CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019400	Acidipropionibacterium acidipropionici strain WSH1105 chromosome, complete genome	15 crisprs	cas3,WYL,DEDDh,csa3,DinG	0	4	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019400_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_1

753821-753930

Orphan

Consensus_repeat	Method
GGGGGGCAACCCCCCTGCACCCCCTGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_1

>merge|NZ_CP019400|1|753821-753930|CRISPRCasFinder
GGGGGGCAACCCCCCTGCACCCCCTGGCGGCAACCTCGCAGATCCCACGACCGCGTCGCAGGCCGGACAGCGCACCCCAGGGGGGGGCAACCCCCCTGCACCCCCTGGCG

>NZ_CP019400|1|1|753821-753930|CRISPRCasFinder
GGGGGGCAACCCCCCTGCACCCCCTGGCG	GCAACCTCGCAGATCCCACGACCGCGTCGCAGGCCGGACAGCGCACCCCAGG
GGGGGGCAACCCCCCTGCACCCCCTGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_028701837.1\|749108_749591_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_CP019400.1\|WP_028701844.1\|758175_758373_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP019400.1\|WP_028701850.1\|765758_766475_-\|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl\|CDD\|235829
NZ_CP019400.1\|WP_036938780.1\|764187_765699_-\|L-arabinose-isomerase	unknown	unknown	gnl\|CDD\|179503
NZ_CP019400.1\|WP_028701839.1\|751393_752065_-\|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl\|CDD\|377432
NZ_CP019400.1\|WP_154662090.1\|760508_761027_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028701848.1\|763048_764062_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP019400.1\|WP_028701851.1\|766816_768211_+\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340917
NZ_CP019400.1\|WP_051281980.1\|740221_740842_-\|biotin-biosynthesis-protein-BioY	unknown	unknown	gnl\|CDD\|224187
NZ_CP019400.1\|WP_028701840.1\|752857_753817_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223739
NZ_CP019400.1\|WP_015070787.1\|750197_751058_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234781
NZ_CP019400.1\|WP_028701842.1\|755230_756583_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163
NZ_CP019400.1\|WP_028701846.1\|759162_760164_+\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|372671
NZ_CP019400.1\|WP_028701371.1\|741966_742674_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236983
NZ_CP019400.1\|WP_028701845.1\|758510_759065_+\|antirestriction-protein-ArdA	unknown	unknown	gnl\|CDD\|377800
NZ_CP019400.1\|WP_015070790.1\|752194_752776_-\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|378626
NZ_CP019400.1\|WP_051282148.1\|761313_762429_+\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NZ_CP019400.1\|WP_015070788.1\|751069_751336_-\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|212154
NZ_CP019400.1\|WP_028701372.1\|740975_741974_-\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP019400.1\|WP_015070786.1\|749627_750149_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_028701837.1\|749108_749591_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	1.85723e-13
NZ_CP019400.1\|WP_028701844.1\|758175_758373_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.60495e-07
NZ_CP019400.1\|WP_028701850.1\|765758_766475_-\|L-ribulose-5-phosphate-4-epimerase	gnl\|CDD\|235829	PRK06557, PRK06557, L-ribulose-5-phosphate 4-epimerase; Validated.	4.40997e-147
NZ_CP019400.1\|WP_036938780.1\|764187_765699_-\|L-arabinose-isomerase	gnl\|CDD\|179503	PRK02929, PRK02929, L-arabinose isomerase; Provisional.	0
NZ_CP019400.1\|WP_028701839.1\|751393_752065_-\|nicotinamide-mononucleotide-transporter	gnl\|CDD\|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	1.12437e-42
NZ_CP019400.1\|WP_028701848.1\|763048_764062_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	4.01771e-112
NZ_CP019400.1\|WP_028701851.1\|766816_768211_+\|sugar-porter-family-MFS-transporter	gnl\|CDD\|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.33239e-136
NZ_CP019400.1\|WP_051281980.1\|740221_740842_-\|biotin-biosynthesis-protein-BioY	gnl\|CDD\|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	4.29784e-27
NZ_CP019400.1\|WP_028701840.1\|752857_753817_+\|aldo/keto-reductase	gnl\|CDD\|223739	COG0667, Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion].	8.05385e-98
NZ_CP019400.1\|WP_015070787.1\|750197_751058_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|234781	PRK00489, hisG, ATP phosphoribosyltransferase; Reviewed.	1.82391e-138
NZ_CP019400.1\|WP_028701842.1\|755230_756583_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0
NZ_CP019400.1\|WP_028701846.1\|759162_760164_+\|IS481-family-transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	4.18466e-22
NZ_CP019400.1\|WP_028701371.1\|741966_742674_-\|hypothetical-protein	gnl\|CDD\|236983	PRK11788, PRK11788, tetratricopeptide repeat protein; Provisional.	7.09734e-05
NZ_CP019400.1\|WP_028701845.1\|758510_759065_+\|antirestriction-protein-ArdA	gnl\|CDD\|377800	pfam07275, ArdA, Antirestriction protein (ArdA). This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.	1.79564e-27
NZ_CP019400.1\|WP_015070790.1\|752194_752776_-\|DUF3090-domain-containing-protein	gnl\|CDD\|378626	pfam11290, DUF3090, Protein of unknown function (DUF3090). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.47393e-71
NZ_CP019400.1\|WP_015070788.1\|751069_751336_-\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|212154	cd11547, NTP-PPase_HisE, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. This family includes M. tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. M. tuberculosis HisE is encoded by the hisE gene, which is a separate gene presenting in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants. HisE is responsible for the second step in the histidine-biosynthetic pathway. It can irreversibly hydrolyze phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate. HisE dimerizes into a four alpha-helix bundle, forming two inferred PRATP active sites on the outer faces. M. tuberculosis HisE has been found to be essential for growth in vitro, thus making it a potential drug target for tuberculosis.	3.12418e-40
NZ_CP019400.1\|WP_028701372.1\|740975_741974_-\|HAD-IIA-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.12177e-81
NZ_CP019400.1\|WP_051282148.1\|761313_762429_+\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.25008e-14

>NZ_CP019400.1|WP_028701840.1|752857_753817_+|aldo/keto-reductase
MLARTVGASGLKVSRMGLGTLTWGGQTDTRDARTMLRSFVEAGGNLVDTAPAYGSGAAEKLIGRVIHSDLDRDDLVIATKAGFTVNGENRVVDTSRAAMLRDLEGSLRRLHTDHVDLWQVHAWGDAPLEETCDALDHAVRSGMARYVGVSNFVGWQSATAATWQRALRSRIPIISNQVEYSLLARRAEIEMMPSAHHHRMGVLAWSALGRGVLTGRYRTGTPKDSRGANDQLSWFVEPYLAAKSRAVVEAVAKAAQGLGVTTAQVALSWVRDAPQVASALVGARTPEQLDELLATDDEQLPAEITAALDDITGGANLMR
>NZ_CP019400.1|WP_015070790.1|752194_752776_-|DUF3090-domain-containing-protein
MARLTHRYLRPDRFVCGTVGRPGERTFFIQTRQDGQITSVRCDKEQLQVLTTHLARILDDLARLAAGGILVPGPVDEPVDDEPLDMPLEEEFTAGAIAIAWDSAAGRLVVEVFAISDDEMMEADPQLLLAASPQDAPDSLEVHLSPAQARDFVARGQLVISSGRPACPFCGQPISGSGHICPRANGYRRPLFL
>NZ_CP019400.1|WP_028701839.1|751393_752065_-|nicotinamide-mononucleotide-transporter
MGDVIMRFLNAQLDIGLGRPVLWREIIGNIFGLASALGGARRRIWAWPVGIVGNVLLFTVFLGGVFHTPQDLNLWGQAGRQVFFLITSAYGWVQWAAYRRSHRSSGGAAVAPRWATPKERMATAAAVVMLIVFYIVLKALGSWGPASDSWILTGSILATFGMARGWNEFWFIWIAVDLVGVPLLLSAHYYPSGLMYIFYGGFCLYGFFTWWRLRDQDRSVDIP
>NZ_CP019400.1|WP_015070788.1|751069_751336_-|phosphoribosyl-ATP-diphosphatase
MSKTFEELFAELSRKAAERPEGSGTVAELDRGVHAIGKKIVEEASEVWIAAEYEGNERTAEEISQELYHLQVMMVRLGIGLEDVYKYL
>NZ_CP019400.1|WP_015070787.1|750197_751058_-|ATP-phosphoribosyltransferase
MSGQNVLRIAVPNKGALSEAAASLLSEAGYRQRTDRKDLRLLDEANGVEFFYLRPRDIAIYVGEGTLDLGITGRDLLLDSMAQAVEVRGLGFGRSRFRFAAPAGRHNTVEGLAGRRIATSYPGLLRSYLDERGIDAHLIHLDGAVESSIGLGVADAIADVVETGTTLRKAGLEIFGEVILESEGVLIRRHGFEAGSAYEHFMKRIEGVQVARSYVMLDYDVPEANLAAASDLTPGLEAPTVSPLSRQGWYAVRAMVPRGQVQTLMDQLWDAGARAILSTDIAACRI
>NZ_CP019400.1|WP_015070786.1|749627_750149_+|hypothetical-protein
MADSTLTIIVSVVLIALPLLWGVLHWARRRSVRSMVRSIGLALVPAGLWILGVMGMVTQWGRQAVDWVRATTMDTTRWVGVAIAGVGVIAMITGSFIAPVTRQQARERRSGSRETTSGGSAKQVGPAKKPVQPPASKAAQKPGGKKQAGNPDKAGFTDEDRELMELLKERGID
>NZ_CP019400.1|WP_028701837.1|749108_749591_-|SseB-family-protein
MVSLLKPGGDLGDADEPTRAAMAAATTREGYLDAVVAMCSSRLLMPVMSPGASAPEGSTQVTELGAAVLTNERGESALLCFTGIDSLQAWDARARPVPGTLDDLAATVEEAGASSLLVDVAGPVPMVIGPDLVVQLSRGRRLVRLSDGYGWLEVTPGDRV
>NZ_CP019400.1|WP_028701371.1|741966_742674_-|hypothetical-protein
MDFDEKALPPSVKAELRGVPSDVAHIIEGHLVAAAELIDTDPELANKHAQAARRRAARLPVLREAAADTAYAAGEFASALNDYRTLRRMTGNDNYLPVMADCERALGRPQAALRLIKEAEEAGDLSSSQSVELVLVKAGARQDMGQDAEALRLLHSAVSGVHGSDEARARLYYAYAEALLRKGDTAAAREWFTSSDDLDASGLLDADERIARIDGVDLGDEDEQDDGEDPEDSDD
>NZ_CP019400.1|WP_028701372.1|740975_741974_-|HAD-IIA-family-hydrolase
MTEAVIDAYDAALFDLDGVIYLGPEAIPAAPATVEALLGRGIQVGFVTNNAARSTEVVAEQLNGMGIPVTRADVVSSAEAIAQLVAEQLPAGSPVLVAGAQALIDEVAGHGLRPVSSADDGPVAVIQGYDPQMTWPRLDECCIAIQRGARWYVSNPDSTRPTDRGLVPGAGAQMAVVATSVTGEPVMAGKPHRPLLDATVARLGCHRPIFVGDRLDTDILGANRAGMDSLLVLTGAHGGHDLLDAEPQFRPTRIARDLSGLLEPERRAVVEGGRAVCGHAEAQEVDGVVRITSAIGGDLDGQLDALAAVLALVWEGAARGEHDELDRLDLVH
>NZ_CP019400.1|WP_051281980.1|740221_740842_-|biotin-biosynthesis-protein-BioY
MADTTSPQASVKARAGGFQGTDLALIAVFAALVAVLSVIPPLFVVAAVPFALQMVAVMLTPLVLGAVRGGAALALYLVVGLLGLPVFAGQSSGPGVLLGATGGFLIGYIVAALAAGALATAVLRRRPRKPVLAVQLYLVALVDLVVVYAFGIAGMMINASLSLPAALAANGLFMVGDLVKALLAVAIAVAVLTAFPRLMPAVRAPR
>NZ_CP019400.1|WP_028701842.1|755230_756583_-|M20/M25/M40-family-metallo-hydrolase
MDQPTDPEVRAADSPDAEVVPICQELVRIDSSNYGRHDARGETEVARLVAGLLSEIGVRSRIYESEPGRATLVAEWAPEGTDMSRPALLLHGHSDVVPAVADDWSIDPFSGELRDGCLWGRGALDMKGYLAMVLSAIRARHRRGQPPSRPIRFILFADEEGSGTLGSTWLGAHHPEAFDGVTEAISEVGGFSVTTPGGQRAYVVQAAEKGLWWFRMTATGSAGHGSMRNRDNAVSRLAEALGRISGYAWPDLHHPVQEEFLSRFEQLWGIGVDHDRLEESLAALGPLSRMVAACSANTVTPTVLSAGYKVNVIPTSASAELDARFIPGHEQEMIDTIKGLAGPGIEFETISHKPSAEAPFEGPAVDAIRSALAVEDPGAVVLPYLNSAGTDAKGFARLPDGRVINCYGCTPLRLPPDFDFISLFHGVDERVPLDTLAFGARVVDHILQEA
>NZ_CP019400.1|WP_028701844.1|758175_758373_+|helix-turn-helix-transcriptional-regulator
MSRRPNPAKGIGKDIRDARKSQHRLASEAGISRPTIARVETGSNISTGTLEKVAKALGKRLRIDA
>NZ_CP019400.1|WP_028701845.1|758510_759065_+|antirestriction-protein-ArdA
MTTTSPQTTDTTPRAWLGCLSCYNAGRLVGDWFDAVDADAVTSYDIHGAHSRADSHDELWVFDHENLPVSGELDTVTAASWGRCLAEVDEHLRPALCAWIRSGDYVAEGNSDLPSIGDFEERYCGEWDSFREYAESPVDDVGLLDGVPEEIANYFDWTSWTRDLAMDYSTYPNPDGGVYVFRDL
>NZ_CP019400.1|WP_028701846.1|759162_760164_+|IS481-family-transposase
MTHANAPLTPEGRRRLAVLVVEQGWSLRRAAERFQCSPATVKRWADRYRAGLPLIDRSSRPTSSPNRLSRKTEHRIVALRFTRRWGPHRIAYHLRLHRSTVGRVLARYKMPKLINIDQATGLPVRRPKPTRYEVAAPGQLVHVDIKKQGRIPDGGGWRAHGRGSMQDRHAGVARDKAARAGAAGSRGYRYLHHAVDDHSRIAYSEILDDERKETAAGFWTRANAFFAGLGVTVTAVMTDNGSCYRSGAFADALGDHVKHKWTRPYRPQTNGKVERFNRTLAVEWAYAKPYASEAERAAAYETWLHHYNHHRPHTGIGGQTPSARVHNVTGKYT
>NZ_CP019400.1|WP_154662090.1|760508_761027_-|hypothetical-protein
MATSAVATSAQAAGSERATTEVNPVSVIAKAKHDSPKSLAEKVAILRKSDALMDLFVGSPDSRTTNTYLEFFAAISTIDQVRGFVEKTAGKHFVASGPDSNPTVTLEDGLPISARGSCCKCWKARVASIAYFAASGLTCAAVGAMTGAVGGFVCGGVFYAMESLPNFDAACK
>NZ_CP019400.1|WP_051282148.1|761313_762429_+|IS630-family-transposase
MASPRTEPVHLTDEERAVLEGWTRGRTLAAWRARRARIILELDGGATIGRAAELVGCSRTTVGKWRSRFAADRLDGLEDAPRPGRPRAVTDEAVQALVERTLHSKPTNGDRAWSTRSAAQASGMSQSMVSRVWRAFGLKPQAIDSWKLSTDPEFVDKVRDVVGLYMDPPADALVLAVDEKTQIQALDRTAPILPVLPTSPAKASHDYVRHGTTSLFAALDIASGSVITEHHARHTAAQFIGFLTTIDKAVPQDLDLHLVLDNYATHKTAKVHTWLLRHPRFHLHFTPTYSSWLNLVERWFAELTCRKLHGSAHRSVTELKADIQAWINQWNHDPKPFIWTKTADQILSTLAAYCTILNHTNDQPETSDSGH
>NZ_CP019400.1|WP_028701848.1|763048_764062_-|LacI-family-transcriptional-regulator
MSETSRPPGMMDVARLAGVSHQTVSRVLNNADSVRPATREKVRRAIAELGYRRNLSARALVTNRTRVIGVVVARGGYYGPGSTSSAIQTAARGRGYATIVASLRDGSPGELAAVVDMLTDHGVEGITAIAPQLGFVEGLRKVARSVPIVVVADGFEVSEGMHPVSVDQRHGARLATQHLIGLGHRRIAHISGPDDWFDSRERVIGWRETLQDAGLEVPEVMVGDWSAESGYAMGGRLLEEGLPDAVFSSNDTMALGLLACLADLGIRVPDDISLVGYDDANGAAFFQPPLTTIRQPFEELGARCVEVLLEAIEGHEPEPQRIRPSLRVRRSCRRHQN
>NZ_CP019400.1|WP_036938780.1|764187_765699_-|L-arabinose-isomerase
MINNPFEAKEIWFFTGSQDLYGPEVLDQVAAQSKEIAAQIDGASTVPVKIVWKPVLKDREAIRTAALEANADDACVGVIAWMHTFSPAKMWILGMDALTKPLLQLHTQYAEKLPYATLDMDYMNLNQSAHGDREFGYLLTRLGKNRRIVVGHASHPDTALRIGTWARAATAWNALHHMKLARFGDNMRNVAVTEGDKTEAELRLGVSVNTWSVNDLVEVVDAVEESSIDELVATYDAQYDVAEELRPGGAARESLRYGARIELGLRKFLDDGGFEAFSTNFEDLGGLRQLPGLAVQRLMADGYGFGAEGDWKTAVLVRIAKIMGYGLDGGASLMEDYCYEFTPGKEKILGAHMLEICPSLTGKKPSLEIHPLDIGGREDPVRLVFDADPADGLVVALSDMRERFRLTANIVKIVGPDEPLPNLPVARAVWEPAPSFQTSTECWLTSGGAHHTVMTTNTDREMWEDLADIADIELALIDEDTTVRGFAKERLLETAIHRLNGGR
>NZ_CP019400.1|WP_028701850.1|765758_766475_-|L-ribulose-5-phosphate-4-epimerase
MTIHLSELDAGTRGLVAQTRQTVSDLHAELPRNNLVVWTAGNVSQRVPGTELFVIKPSGVSYDELTADAMVVCTLDGKKIDDGTPEHLQPSSDTAAHAYVYRHMPEVGGVVHTHSPYATAWAARREPVPCVLTMMGDEFGGEIPVGPFALIGDDSIGRGIVETLSHSNSRAVLMANHGPFTIGKDGRDAVKAAVMCEEVAKTVHFARQLGEPVPIPADDVAHLFDRYQNVYGQHDENA
>NZ_CP019400.1|WP_028701851.1|766816_768211_+|sugar-porter-family-MFS-transporter
MTSASSDKKISSKFIYFFGSFGGILFGYDIGVMTGALPFLQTDWGINEGFESGAATSSVMFGAIFGGALAGQLADRLGRRRMILISALVFILGSLLSGVSPHNGLVFLVCSRIILGLAVGAASALVPAYMSEMAPARLRGSLSGINQTMIVSGMLISYVVDFLLKDLPTSWGWRLMLALAAVPALILFLGVLNLPESPRYLVRRGLIPQARRVLGYIRRPEDIDAEIADIQRTAEIEEQAAEKTSWSSLFNSKYRYLVIAGVGVAAFQQFQGANAIFYYIPQIVGKAGNSAATDALFWPIINGIILVVGSLVYIAIAEKFNRRTLLTVGGTVMGLSFLLPSLIHAVMPTAPGMLIVVFLCIYVAFYSFTWAPLTWVLVGEVFPLAIRGRASGLASSFNWIGSFAVGLLFPVMAKAMPQAAVFAIFGVICILGVLFVRFRVPETRGHTLEEIEAQGTSHAKKAGV

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Crispr_ID: NZ_CP019400_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_2

1028404-1028525

Orphan

Consensus_repeat	Method
CGCTGACCCAGGGTCTGCGTCGCTGGCCTCGCGCTGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_2

>merge|NZ_CP019400|2|1028404-1028525|CRISPRCasFinder
CGCTGACCCAGGGTCTGCGTCGCTGGCCTCGCGCTGCGGGTCGGGTCAGTGGGCGCGTTCAACCTCCTCGTAGCGGCGGTTGACGCTGACCCAGGGTCTGCGTCGCCGGCCTCGCGCTGCGG

>NZ_CP019400|2|2|1028404-1028525|CRISPRCasFinder
CGCTGACCCAGGGTCTGCGTCGCTGGCCTCGCGCTGCGG	GTCGGGTCAGTGGGCGCGTTCAACCTCCTCGTAGCGGCGGTTGA
CGCTGACCCAGGGTCTGCGTCGCCGGCCTCGCGCTGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_051282144.1\|1025467_1026079_-\|DUF2017-family-protein	unknown	unknown	gnl\|CDD\|378185
NZ_CP019400.1\|WP_028701832.1\|1021803_1022664_-\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NZ_CP019400.1\|WP_015071075.1\|1036614_1037007_-\|DUF3499-domain-containing-protein	unknown	unknown	gnl\|CDD\|378788
NZ_CP019400.1\|WP_081583395.1\|1025118_1025415_-\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NZ_CP019400.1\|WP_015071064.1\|1026104_1026419_-\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP019400.1\|WP_015071066.1\|1028077_1028353_+\|DNA-binding-protein-HU	unknown	unknown	gnl\|CDD\|259859
NZ_CP019400.1\|WP_154662089.1\|1028624_1029095_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224555
NZ_CP019400.1\|WP_028701067.1\|1035300_1036362_-\|phosphoheptose-isomerase	unknown	unknown	gnl\|CDD\|378434
NZ_CP019400.1\|WP_081583393.1\|1022684_1023146_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370243
NZ_CP019400.1\|WP_015071071.1\|1033833_1034349_-\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
NZ_CP019400.1\|WP_097959121.1\|1030591_1032379_-\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|237737
NZ_CP019400.1\|WP_081685390.1\|1034351_1035311_-\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP019400.1\|WP_028701835.1\|1026607_1027951_+\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NZ_CP019400.1\|WP_081583394.1\|1023013_1025122_-\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447
NZ_CP019400.1\|WP_051143550.1\|1020955_1021729_-\|ribonuclease-PH	unknown	unknown	gnl\|CDD\|178914
NZ_CP019400.1\|WP_028701831.1\|1020326_1020959_-\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP019400.1\|WP_015071074.1\|1036358_1036583_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225391
NZ_CP019400.1\|WP_028701069.1\|1032415_1033231_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP019400.1\|WP_015071070.1\|1033430_1033679_+\|DUF3039-domain-containing-protein	unknown	unknown	gnl\|CDD\|378609
NZ_CP019400.1\|WP_028701567.1\|1029085_1030456_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_051282144.1\|1025467_1026079_-\|DUF2017-family-protein	gnl\|CDD\|378185	pfam09438, DUF2017, Domain of unknown function (DUF2017). This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases.	1.23263e-25
NZ_CP019400.1\|WP_028701832.1\|1021803_1022664_-\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	2.1228e-124
NZ_CP019400.1\|WP_015071075.1\|1036614_1037007_-\|DUF3499-domain-containing-protein	gnl\|CDD\|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	1.29203e-50
NZ_CP019400.1\|WP_081583395.1\|1025118_1025415_-\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	1.83977e-06
NZ_CP019400.1\|WP_015071064.1\|1026104_1026419_-\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	1.07882e-29
NZ_CP019400.1\|WP_015071066.1\|1028077_1028353_+\|DNA-binding-protein-HU	gnl\|CDD\|259859	cd14435, SPO1_TF1_like, Bacteriophage SPO1-encoded TF1 binds and bends DNA. This group contains proteins related to bacillus phage SPO1-encoded transcription factor 1 (TF1), a type II DNA-binding protein related to the DNA sequence specific (IHF) and non-specific (HU) domains. Type II DNA-binding proteins bind and bend DNA as dimers. Like IHF, TF1 binds DNA specifically and bends DNA sharply. Bacteriophage SPO1-encoded TF1 recognizes SPO1 phage DNA containing 5-(hydroxymethyl)-2'-deoxyuridine as opposed to thymine, Related family members includes integration host factor (IHF) and HU, also called type II DNA-binding proteins (DNABII), which are small dimeric proteins that specifically bind the DNA minor groove, inducing large bends in the DNA and serving as architectural factors in a variety of cellular processes such as recombination, initiation of replication/transcription and gene regulation. IHF binds DNA in a sequence specific manner while HU displays little or no sequence preference. IHF homologs are usually heterodimers, while HU homologs are typically homodimers (except HU heterodimers from E. coli and other enterobacteria). HU is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. IHF is an essential cofactor in phage lambda site-specific recombination, having an architectural role during assembly of specialized nucleoprotein structures (snups).	2.68152e-36
NZ_CP019400.1\|WP_154662089.1\|1028624_1029095_-\|hypothetical-protein	gnl\|CDD\|224555	COG1640, MalQ, 4-alpha-glucanotransferase [Carbohydrate transport and metabolism].	1.17777e-09
NZ_CP019400.1\|WP_028701067.1\|1035300_1036362_-\|phosphoheptose-isomerase	gnl\|CDD\|378434	pfam10432, bact-PGI_C, Bacterial phospho-glucose isomerase C-terminal SIS domain. This is the C-terminal SIS domain of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologs to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate. It is associated with family SIS, pfam01380.	8.98513e-05
NZ_CP019400.1\|WP_081583393.1\|1022684_1023146_-\|hypothetical-protein	gnl\|CDD\|370243	pfam09012, FeoC, FeoC like transcriptional regulator. This family contains several transcriptional regulators, including FeoC, which contain a HTH motif. FeoC acts as a [Fe-S] dependant transcriptional repressor.	0.000107262
NZ_CP019400.1\|WP_015071071.1\|1033833_1034349_-\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	4.4021e-75
NZ_CP019400.1\|WP_097959121.1\|1030591_1032379_-\|4-alpha-glucanotransferase	gnl\|CDD\|237737	PRK14507, PRK14507, malto-oligosyltrehalose synthase.	4.21305e-142
NZ_CP019400.1\|WP_081685390.1\|1034351_1035311_-\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	3.09354e-35
NZ_CP019400.1\|WP_028701835.1\|1026607_1027951_+\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NZ_CP019400.1\|WP_081583394.1\|1023013_1025122_-\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NZ_CP019400.1\|WP_051143550.1\|1020955_1021729_-\|ribonuclease-PH	gnl\|CDD\|178914	PRK00173, rph, ribonuclease PH; Reviewed.	4.19232e-155
NZ_CP019400.1\|WP_028701831.1\|1020326_1020959_-\|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.67343e-88
NZ_CP019400.1\|WP_015071074.1\|1036358_1036583_-\|hypothetical-protein	gnl\|CDD\|225391	COG2835, COG2835, Uncharacterized conserved protein [Function unknown].	2.60768e-11
NZ_CP019400.1\|WP_028701069.1\|1032415_1033231_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	3.37181e-21
NZ_CP019400.1\|WP_015071070.1\|1033430_1033679_+\|DUF3039-domain-containing-protein	gnl\|CDD\|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.02438e-33
NZ_CP019400.1\|WP_028701567.1\|1029085_1030456_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	8.43824e-26

>NZ_CP019400.1|WP_015071066.1|1028077_1028353_+|DNA-binding-protein-HU
MTKSELIKAIAKQASLTEAQTNEAVKALTDVITDALAKGEKIQLPGLLTAETVERPARNGRNPRTGESMTIPAHKAVKLSASSTLKKAVSD
>NZ_CP019400.1|WP_028701835.1|1026607_1027951_+|nicotinate-phosphoribosyltransferase
MSTALLTDHYELTMVEAAMRAGTTWRRCVFELFPRRLPEGRRYGVVAGVGRMLEALEEFRFDPAEIAFLTDRGIVSPEMAEWLAGYRFSGSIHGYAEGDLYFPGSPLLTVEGSFAEACILETLLLSIYNHDSAIASAASRMVMLAEGRPIIEMGSRRTHEEAAVAAARAAWITGFGPTSNLAAGMRYGVPTSGTAAHSFTLLHDTEEQAFAAQLETYGDQTTLLVDTYDIEAAVRTGVRLTDGRLGAVRIDSGDLSIVARQVRDLLDDLGATQTRVIVTSDLDEWQIAALRGAPVDGFGVGTSLVTGSGAPTCSFVYKLVARAASDDPDAPLIPVAKKSSHKSTVGGRKYALRRLDPDGTATAEVVGVGHAPRADADDRDLIVPLVLDGATVGAEPLAVARSRHESAMKELPLSGRRISRGDQAIPTIMVHHGSDGSDAVLGGGLDL
>NZ_CP019400.1|WP_015071064.1|1026104_1026419_-|ATP-dependent-Clp-protease-adapter-ClpS
MVDPVVVAPQASLPAGEPVTERFTAPEPSWATVVWDDPVNLMSYVARVFATYFGYSRAKANDLMITVHNEGSAIVATGPKESMETAVSAMHSYGLWATLSRLER
>NZ_CP019400.1|WP_051282144.1|1025467_1026079_-|DUF2017-family-protein
MRITAGEPPWALEFEPEETWMLGVLLDVYESLVSGEQGPVDRPLDPSDPAGLLGAVQPNHPSDPFSFWEADLDERPGEEPQDDPALRRLFPDAYPDDQDASDEFRRFTAAGQRRERLDQILDVRVDLDVLSTKPLMMQPERVEYWLRTINAIRLVLATRLGIVDELSADRAEQSAGDDPSDVIYPAYEWLGVLIEMLVEVSWE
>NZ_CP019400.1|WP_081583395.1|1025118_1025415_-|ferrous-iron-transport-protein-A
MSSRATRHAVDAVLPTGRADDEPLASCPVDEQRVLLRAEGDLRMRRRLAALGLRRGAPVTLMMRTSGGGAVVSVAGARIALDRSMLSSLHTVSAEAVA
>NZ_CP019400.1|WP_081583394.1|1023013_1025122_-|ferrous-iron-transport-protein-B
MSPKVAEDAVRDLSGHSRKPVLSAKACCADGPDEAATGAPVVALAGAPNVGKSTLFNLLTGARVSMGNWPGTTVSVSRGVWHTRHTAGAPVEVDCDCPEGECGCDHIADHDRDLTLIDLPGAYSVDPMSPDEALTRALLVDCPPSEAPDLVVVVADAAHLARSLYLVAQLRELPLRIIVALTMVDVARRHGIDVDTWALSEGLGVPVVALDPRRRHGDQTLAMAVRRELDDLPPCPREIALDEEMAAVVASEDLDDDAEMAREDERFSFIESVVASGTTSSGQDRRTLSDRIDRWVTHKVFGPLIFAAVMWVVFQITTTVAAPFQDWLDGLFSGPVSEWTHTGLSAIGLGDTWVDGLLVNGVIAGVGTVLTFAPLMALMFILLAILEDSGYMARAAVVTDRMMRTIGLPGRAFIPLIVGFGCNVPAISATRALPQARQRILTALLVPFTSCTARLTVYVMLAATFFPRMAGTVCFIMYLVSILLVVVVGLLLRKTLWRTMGSEPLVLDLPPYQVPTARLTAAVTWMRLKGFLRTASGIIVVAVAAVWLLQSIPVGGHAGFGEAAPEDSAFGVGARAVAPVFEPAGFGSWQTSSALVVGFVAKEAVVSSWAQTYAVADPEETGQQEPLQQKITQSFEQSSGGHTYPAVWAFLFFLLSYTPCVATLATQKREIGLGWTLFGLSMQLAIAWIGAVAIFQIGSLLW
>NZ_CP019400.1|WP_081583393.1|1022684_1023146_-|hypothetical-protein
MRGDSGHPETRDRPGLDPLRTVHAAGHRLDRRGGHLPDREPAVVSPAAAAVTAREGAPRPARPLSRVLEAFRAGAVSLDQIAERTGLPATIVRTSVGHLIRMGRIQAKELSMGCPGGGCSSCASATAEGTPGCGASGPSPLRRGPVLVELRLR
>NZ_CP019400.1|WP_028701832.1|1021803_1022664_-|glutamate-racemase
MTTDNPDGIGYPIGIFDSGFGGLTVARAAVDLMPNEDIVYLGDTARAPYGEKRIAQVREYALQCLDRLDFHGVKALVIACNTASSAVLRDARERYDVPVIDVIMPAARRASLATRNGRIGVICTEATARSRSYEDALAAVPGVTVTTIPCPRFVEYVERGVTGGPELEALARSYLEPIREAGCDTLILGCTHYPLLAGLITLVLGDEVTLVSSSEECARASYTALTRLGILHTEPREPSRYFLTTGNAEKFERLGRRLMQGFVHDVHRVGMDDQPAPLGDLAFVKP
>NZ_CP019400.1|WP_051143550.1|1020955_1021729_-|ribonuclease-PH
MSASEARVGTVSELSSQTRIDGRALDQLREVTIKRSWLSQAEGSVLVSFGRTTVLCNASVTEGVPRWRRGSGLGWVTSEYEMLPRATNDRSQRESRKGKIGGRTHEISRLVGRSLRAVVDYRALGENTIVVDCDVLQADGGTRTASITGGFVALWDAIAWLRGRGSLAGEPLTGSVQAISAGIVGGVPMLDLAYEEDSSADTDMNIVMSGSGDFIEIQGTAEGQPFNRALLGQLLDLGTKGCAELKAAQEAALGVEL
>NZ_CP019400.1|WP_028701831.1|1020326_1020959_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MSRVVLASHNRAKLAELQRVFEAAGSDVEVVGSADVADYPPPDETGTTFVDNALIKAREAVARTGLPALADDSGIEVDALNRMPGIRSARWSGPEATDEKNLRLLLDQTYDLLSERRTARFVCAMAFVGVDGAVITRTATMEGRVIGEARGDNGFGYDPMFVPDEQEGSLTSAEMTPDQKDAISHRGKAVRAIVPEVVAQVAGAAPEQEH
>NZ_CP019400.1|WP_154662089.1|1028624_1029095_-|hypothetical-protein
MLAPERCPLDRVDSLSSNTHHPWSQRASPLFGPDPSPRRRWIKAESVDSERAQAVAEREQWVQELRNRGALASACPTDEEIVVAMHRLLTWTPSRILNATLTDAVGDRRTQNLPGTVNEYPNWRVPLSGPDGRPMWLEDLYVDQRAARIADVLNGN
>NZ_CP019400.1|WP_028701567.1|1029085_1030456_+|IS1380-family-transposase
MQVSHEPVTAPTPVFDEDHLVAAGGLPAILGLAEQADFISLLAGRLTVDCPNAPLKARSLVAGMLAGADDIDGTGILRTGGTPKVMGGVRAPSTLGTFLRSFTHGHVLQLGAVNRKLLEHLAPVVPGLFGADPLITVDLDDTIRELHGYRKQGVAYGYNKVKGLNAILAVVSSDSCPPVITGAGLRRGNVKSGDHAAWHATRSITLARTVRPGTQILGRADSAFCTCETIHAFADHGCWFSVTIPAWPTVTAAISGIDEQAWTPIRYPHAVIEPETGELISDAEVAETPFTAFVSHPKDEQVSCRLVVRRVKRLNPAGQDPLVESYRYHAFITNSDLDTVEADRRHRDHAIVEQVIAELKAGPLAHLPSGRFTANAAWLACAVIAFNLSRAAAHAAGMSTARMPTITRRLIMIPARIAHRARRRYLHMPRRWPWATQFTRLWTTATAVGPPLALAS
>NZ_CP019400.1|WP_097959121.1|1030591_1032379_-|4-alpha-glucanotransferase
MPLTDPALVALAEHFGVARSFTDWKGRQTFVDDETIRAVLGGLGIDAGTPEKAEEALVAVEERPWRRTLPPCTVLRQGQEGRIDVHLPAGQQVEVSIELEDGRSRSCWQVDNWNPDRQIDGRQVGEATFGIPSDLPLGYHTVVAGTVDRRSTASLIVTPSWVGLPAAMESRRVWGYATQIYSVRSHNSWGMGDLTDLADLCTWSATQGADYLLINPLHAAEVVPPMEPSPYLPSSRLFLNPVYVRPELIPEYQDLDDAARDHARALRVEAVGNDTAAERIDRDRTWTRKRPVLEEIHRTGLGPARRMAFRAFRRLRGSRLSDFAAWCAISEVHGSNWKLWPEPLQHPGSREVAAFVASHASRVDFYEWLQWIAEQQLSAADRAGRDSGMALGLICDLAVGVSGCGADTWMLPNLFAEGVSVGSPPDQFNQAGQDWGQPPMRPDVLAEMAYRPFREMVAGALRHAGGLRMDHIMGLFRLWWVPLGLGPRKGAYVRYDHEAMVGILALEAYRAGALVIGEDLGTVEPWVRDYLRDRGLFGTSVMWFELDGAGRPLAPEQWREYALSSVTTHDLPPTIGYLAGDHVELRHRLGLLTEP
>NZ_CP019400.1|WP_028701069.1|1032415_1033231_-|RDD-family-protein
MGWYPDPGGSEKERYWDGSRWTRNLRAPREVAAPAARHDRQSGRPETLDPLRTQGTHKVVRRRSADDPQPTAPAPRRQEPYPGGQYPSERSREALTSDGVPLAGWWWRVLATIIDMALVWVVVAIVMHGQFSTFMTRYMNLATQNLGSYNAIIQAVSGDQQLLAASMAITRGTIIGQIVYQFAMLAICSASVGQLVCRLRVVEVDHGQEHRRLRWWRALLRAAVWGAVEFVSQTTLGLLELFSYLMPLWQRRRQTIHDLVGGTQVIRLPRD
>NZ_CP019400.1|WP_015071070.1|1033430_1033679_+|DUF3039-domain-containing-protein
MSTQAAPGSETVVEERTQPSFQDGDAERFSHYVPKAKLTDAIVNGTPVVALCGKVWVPTRNPDRFPVCPECKEIWESLNPGK
>NZ_CP019400.1|WP_015071071.1|1033833_1034349_-|type-II-3-dehydroquinate-dehydratase
MTRVLVLNGPNLGRLGRRQPEIYGSLTHAGLREHLVGTGEGLGLEVEVRQTDSEAEMINWLHEAADEQLPVVINPAAWSHYSIAIADAVAQLEAPVVEVHLSNIAAREEFRHHSVVSAYVTGTIAGLGASGYDYALAHISALTDSEETRTDPAQINPGLTQGMITGRQETV
>NZ_CP019400.1|WP_081685390.1|1034351_1035311_-|cation-diffusion-facilitator-family-transporter
MSTEGGRKAIIAAASANLGIAVTKFAAWALTGASSMLAEAIHSTADTGNQLLLMIGGRAAVREADKEHPFGYGRARYLAAFMVAIVLFSLGGLFALYESYEKIVAVRAGEHDALMESSWWWVPLLVVAISLVAESMSLRTALKETHKARAHLSVLQFIKQAKAPELPVVMLEDSAAVLGLVFALLGIGLTLLTGNEIFDAVGSGCIGVLLVVVAIILGREMLSLLEGESASPENRAAVAEAIRGTAGVGTIIHMRTIHVAPETILVAAKIGLDPGDSAAGVARIIDDAEAAVRSAVPMVGPLYLEPDILRTPGAETKEN
>NZ_CP019400.1|WP_028701067.1|1035300_1036362_-|phosphoheptose-isomerase
MSPAFDDSRLEQETLPPAAEQALRRLASTGARIRTDAGDLEAWCGEAAARLERPRGVLVVGPEARLVRSVLEPQCPVPMVAWPLDRVPAWVGPLDLVVALDSGGVDDPHSCLDAVAEARRRGAAVLLASEVDSPAWRAAGGRSSVRLPMVSGDPMSAAVAVLAVLGRIGIGPDVIPEQVARAADMVAEAASPHRDLALNPAKDMACALADADPLLWGGSVLAARASRRFAEALRRASGRSALSADAAALMPVIMATEPRDPFADPDIDGAAHRPVLVVLDDGAPDPLGSRSRLEEACRRRDVAVRTIGLPLGTEEEGPVGNYVTLLLQGRFAAAYLALGLGRLEGQEGSAGEY
>NZ_CP019400.1|WP_015071074.1|1036358_1036583_-|hypothetical-protein
MPDLPDTPEALDLSPAFLEIAACPECHSKFALDYDRGELVCSSPSCGLAFPVSEGVPDLRVDSARRPARDQEQQ
>NZ_CP019400.1|WP_015071075.1|1036614_1037007_-|DUF3499-domain-containing-protein
MRECSRPGCSRPAVATLTYVYSESTAVLGPLGPAREPNSYDLCEGHSGALSAPRGWEVIRLPGIDEAPPITPDDDLMALARAVRETGMLDGEAGPEHGPLSPAPDSVRVVASRGHLSVIVDSSDAGGRVR

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Crispr_ID: NZ_CP019400_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_3

1165111-1165221

Orphan

Consensus_repeat	Method
GGGAGACGACCCCCTCGCGACCCCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_3

>merge|NZ_CP019400|3|1165111-1165221|CRISPRCasFinder
GGGAGACGACCCCCTCGCGACCCCCGACGCGCCGACCAACCGGGGAGACGACCCCCTCGCGACCCCCGACGCGCCGACCAACCGGGGAGACGACCCCCCCGCGACCCCCGA

>NZ_CP019400|3|3|1165111-1165221|CRISPRCasFinder
GGGAGACGACCCCCTCGCGACCCCCGA	CGCGCCGACCAACCGGGGAGACGACCCCCTCGCGACCCCCGACGCGCCGACCAACCG
GGGAGACGACCCCCCCGCGACCCCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_028700961.1\|1169774_1171487_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP019400.1\|WP_015071190.1\|1161245_1161689_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP019400.1\|WP_015071189.1\|1160695_1161223_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP019400.1\|WP_028700964.1\|1173946_1174594_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366312
NZ_CP019400.1\|WP_015071183.1\|1153315_1155163_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP019400.1\|WP_015071193.1\|1164585_1165071_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP019400.1\|WP_051281809.1\|1157211_1157991_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028700960.1\|1168464_1169778_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223692
NZ_CP019400.1\|WP_071162058.1\|1171483_1172326_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961
NZ_CP019400.1\|WP_015071188.1\|1159577_1160294_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235914
NZ_CP019400.1\|WP_028700959.1\|1167802_1168456_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213052
NZ_CP019400.1\|WP_028700958.1\|1166889_1167480_+\|methyltransferase	unknown	unknown	gnl\|CDD\|225370
NZ_CP019400.1\|WP_028700962.1\|1172457_1173078_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP019400.1\|WP_028700963.1\|1173256_1173946_+\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|235919
NZ_CP019400.1\|WP_015071185.1\|1156199_1157183_+\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP019400.1\|WP_015071191.1\|1162067_1162478_-\|YccF-domain-containing-protein	unknown	unknown	gnl\|CDD\|236975
NZ_CP019400.1\|WP_015071184.1\|1155289_1156114_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP019400.1\|WP_028700954.1\|1157997_1159350_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP019400.1\|WP_028700957.1\|1165986_1166877_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|211337
NZ_CP019400.1\|WP_036937246.1\|1165285_1165990_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_028700961.1\|1169774_1171487_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.03222e-75
NZ_CP019400.1\|WP_015071190.1\|1161245_1161689_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	8.53986e-96
NZ_CP019400.1\|WP_015071189.1\|1160695_1161223_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	4.30772e-72
NZ_CP019400.1\|WP_028700964.1\|1173946_1174594_-\|hypothetical-protein	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	6.86684e-05
NZ_CP019400.1\|WP_015071183.1\|1153315_1155163_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP019400.1\|WP_015071193.1\|1164585_1165071_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.13064e-20
NZ_CP019400.1\|WP_028700963.1\|1173256_1173946_+\|glutamine-amidotransferase	gnl\|CDD\|235919	PRK07053, PRK07053, glutamine amidotransferase; Provisional.	4.48433e-95
NZ_CP019400.1\|WP_028700960.1\|1168464_1169778_+\|ABC-transporter-permease	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	9.64014e-11
NZ_CP019400.1\|WP_071162058.1\|1171483_1172326_+\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	3.40359e-06
NZ_CP019400.1\|WP_015071188.1\|1159577_1160294_+\|SDR-family-oxidoreductase	gnl\|CDD\|235914	PRK07041, PRK07041, SDR family oxidoreductase.	3.99905e-49
NZ_CP019400.1\|WP_028700959.1\|1167802_1168456_+\|hypothetical-protein	gnl\|CDD\|213052	cd12087, TM_EGFR-like, Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases. PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane (TM) helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. They are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. The TM domain not only serves as a membrane anchor, but also plays an important role in receptor dimerization and optimal activation. Mutations in the TM domain of EGFR family RTKs have been associated with increased breast cancer risk.	0.00213839
NZ_CP019400.1\|WP_028700958.1\|1166889_1167480_+\|methyltransferase	gnl\|CDD\|225370	COG2813, RsmC, 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis].	6.69992e-32
NZ_CP019400.1\|WP_028700962.1\|1172457_1173078_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	1.75462e-90
NZ_CP019400.1\|WP_015071185.1\|1156199_1157183_+\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP019400.1\|WP_015071191.1\|1162067_1162478_-\|YccF-domain-containing-protein	gnl\|CDD\|236975	PRK11770, PRK11770, YccF domain-containing protein.	1.32844e-47
NZ_CP019400.1\|WP_015071184.1\|1155289_1156114_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	4.01577e-29
NZ_CP019400.1\|WP_028700954.1\|1157997_1159350_-\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP019400.1\|WP_028700957.1\|1165986_1166877_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|211337	cd02570, PseudoU_synth_EcTruA, Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1). Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E. coli TruA makes psi38/39 and/or 40 in tRNA. psi38 and psi39 in tRNAs are highly phylogenetically conserved. P. aeruginosa truA is required for induction of type III secretory genes and may act through modifying tRNAs critical for the expression of type III genes or their regulators.	6.18598e-97
NZ_CP019400.1\|WP_036937246.1\|1165285_1165990_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	2.42636e-71

>NZ_CP019400.1|WP_015071193.1|1164585_1165071_+|MarR-family-transcriptional-regulator
MGPECAPTQGPDDPSAPPDEDFTSRFTTAISRISRRIRVTSFTMTYGALSALATIDRSGPLRPAELADIERVTRPSITRIVAALESRGYISRTDDPDDGRAFVVAITSSGRTALKQARTERAGDIACLMEGLTDPQLEALHQALPALERIARNASTGTERR
>NZ_CP019400.1|WP_015071191.1|1162067_1162478_-|YccF-domain-containing-protein
MRTLLNIIWLFLGGIWLGLGYLVAGVLACILVVTIPVGLASFRMARYVLWPFGSAVVRRPGAGAGSALMNLVWFVIAGWWLALLHVIAAAAQSITVVGIANAVVSLKMIPVSLFPFGRMIVPRGSLAPGERPLHSV
>NZ_CP019400.1|WP_015071190.1|1161245_1161689_-|50S-ribosomal-protein-L13
MTTYSPKPGEVTRNWYVIDAEDIVLGRLATTAANLLRGKHKPQYAPHIDTGDFVVVVNASKIAVTGNKATKSLRHDHSGRPGGLRTTTIGELLAKNPRRAVERAVWGMMPKNKLSRQQMSKLKVYGGPEHPHAAQKPQPFEITQIAQ
>NZ_CP019400.1|WP_015071189.1|1160695_1161223_-|30S-ribosomal-protein-S9
MTETTNHDENLESEVKPFTEGEREIAYRTDSNPSVAAGEAVRPAVVAPGAATGRRKEAIARVRIVPGSGKWSINGGRTLEDYFPNKVHQQIASEPFATAGVEGSYDVIVRITGGGVTGQAGALRLGIARALNAIDAEASRPALKKAGMLTRDARIKERKKAGLKKARKAPQYSKR
>NZ_CP019400.1|WP_015071188.1|1159577_1160294_+|SDR-family-oxidoreductase
MSTDLTGQRVLVIGGSRDLGLAVARAAASAGAVVIIGARDEQKASDAAASIQNAEWVRMDITDEASVEAGLAGAGKIDHIVILTAAHHNVPVDRLDHDRTVTAFEAKVIGPLMVAKHAAAVLAPTGSIVLFSGVAAWNPQKGFSVMGITNGAVSFAASHLAKELAPIRVNAISPGIIDSGSWDGMGANKQKFLQEAAGGNLVGRWGASSDIADAVVWLLSATFVSGETIHVEGGARHY
>NZ_CP019400.1|WP_028700954.1|1157997_1159350_-|phosphoglucosamine-mutase
MARLFGTDGVRGVANQDLTAELALDLSVAAAHVLGEAGAFGHRQPTALVARDPRASGEFLEAAVCAGLASAGVDVMRVGVIPTPAAAYLVNEYRTDLGVMLSASHNPMPDNGIKFFQRGGVKLADDLEDAIEARMEEPWQRPTGERVGRIRTSTDAVKTYIDHLVASLRQDKTLSGLKVVLDCANGASSKTGPTAFREQGADVTAIHASPDGININDACGSTHPEKLQAKVVELGADLGLAFDGDADRCLAVDHEGNIVDGDQVLAILALGLQEDHRLASNTVVATIMSNLGLTLAMKEHDIHVDQTKVGDRYVLESMNANGFSLGGEQSGHVIMSEFATTGDGVLTGLHVAARVARTGKTLKDLASVMKRLPQSLVNVRGVDKLRAGMDPEVNRAVADANQKLGETGRVVLRPSGTEPLVRVMVEAATQKEADKICHDLATIVKQRLAI
>NZ_CP019400.1|WP_051281809.1|1157211_1157991_-|hypothetical-protein
MGLFIRLRPDPDLGSLDTRSADRVRDLVRSSLDALGIEASVDGGHIDSSLGYLSLEPVARECADQDRGSWPVIVDEVVKRMVRSLVDGADQLSDATIGQHVVWRLLPDAERMGRSFRYVRPVQGADGAVPGVSVALAWDGEETLDVLNDAALSEVRDLDVAFRAGRENLVEDLAAAPVETTELAEGVVEISSPSWLTASWALLPEEVAARFLPGGAPVLLAAPDHRHLLVGPDAEAARTVLGQAAGETPVLPVVRRPSR
>NZ_CP019400.1|WP_015071185.1|1156199_1157183_+|type-I-pantothenate-kinase
MDLTPIPPADDDNTEAGPYIELSRAAFADLAERTDIDIDEEALERIRGLGDPTSQRDVVEIYRPLTQLIHLYCMHTGALFEASDAFLRLGDHGMRRTPFVIGIAGSVAVGKSTVARLLKELLARSPRRPEVELITTDGFLYPNSVLEEKGLLERKGFPESYDRKALLQFVVDVKSGVPEVAAPVYSHISYDIVPDEKVVVRHPDILIVEGLNVLQPPRLRSNNTTGLTLSDFFDFSVYVDAREDDIIDWYLSRFLALRRTAFTDPDSYFTEYAALPDDQAVAVAREIWDQINGPNLRHNVLPTRGRATAILHKGHDHEIESIWIRKI
>NZ_CP019400.1|WP_015071184.1|1155289_1156114_+|methyltransferase-domain-containing-protein
MKTSQSYTETGYTHGHSAPVLAAHATRSAATSAGYLLPELEPGMSLLDIGCGPGTVALDLAERVRPGRVVGVDPSLEALEAARDEASRRGDRTTDFMAADVAELPFADASFDVVHAHQVLQHLQDPVGALREMARVSASLVAVRDVEYRTMSWYPDIPGLDMWLDTYRAIARANAAEPDAGRHLKSWARAAGLEDLQVTASTWCYTDPESVHWWSTSQAARVAGQTFTRQAVEIGRSRADVEEMRRAWLDWGASPDAYFAMVHTELLARVPARR
>NZ_CP019400.1|WP_015071183.1|1153315_1155163_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYCGHQQAEHVIIEGLRRLEYRGYDSAGLAVVADGSLHWAKKSGKLANLVSELESHRLPESTQGIGHTRWATHGAPTDANAHPHLSADGKVAVVHNGIIENFATLKAELIAEGVTFVSDTDTEVAAHLIGRETAKGAGLAEAMGRVASRLAGAFTLVAVSADEPDVVVAARRNSPLVVGLGEGENFLASDVAAFIEHTRDALELGQDQVVTITPESVTVTDFEGRPSEARPYHVDWDLSAAEKQGHDWFMRKEIFEQPKAVADTLLGRWSDRGELVLDELRISPEELRRINKIVIVACGSSFYAGMVAKYAIEHWTRVACEVELASEFRYRDPIIDPMTLVVTISQSGETADTLMAIRHAREQQARVIAICNTNGATIPRESDAVIYTHAGPEIGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEVHAIVDELNSMPDKIQAVLDGIEPVYKLARKMAMSEDAVFFLGRHVGYPVALEGALKLKEIAYLHAEGFAAGELKHGPIAVIEQDTPVFVVVPPEGRDQLHDKVVSNIEEIRARGARTIVLAEEGDAAAESFADMVIPLPKCSTLLQPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE
>NZ_CP019400.1|WP_036937246.1|1165285_1165990_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MRRSPRMNTSQEHAMARLGSRYLVDVPHDTTSTSVAPGSRLDPTEIFGRRAPLTVEIGSGSGDVLASVAAAHPERDFIGFEVYLPSVASSLTRLDHAGARNVRIIIADAAAGLEHLFGPGDLDELWTFFADPWHKKRHHKRRIVSPDLARLVASRLRPGGLWRLATDWQDYADWMLDVLTREPGLVPVDAGPEGYAPRWSERPITRYEKKGVAAGRTVRDLLYRNAREAEETAG
>NZ_CP019400.1|WP_028700957.1|1165986_1166877_+|tRNA-pseudouridine(38-40)-synthase-TruA
MSEVTRRWRLDIAYDGADFSGWAAQPDRRTVQGELERWIPRVLRLDPPVPLTVAGRTDAGVHARGQVAHIDLPAALEPRPDLARRLRRVLEPDVVVRRVSAVPDAFDARFSALWRRYVYRLWDADSDPDPLDRRHVVQVREHLDVDLLNAAGASLLGLRDFAPFCKRREGATTIRTLMDCRAVRLDDPAGTIELTVRADAFCHSMVRSLVGALAAVGASRRRQQWLDEVAASPTRASSVVVMPAAGLTLEEVGYPDEDGLAARAAQSRAVRSADELADCGCDGPDLPTTPTTHAAR
>NZ_CP019400.1|WP_028700958.1|1166889_1167480_+|methyltransferase
MSHYFQTPTGPVETRTIRARIWDEELTFTTAGGVFSGSRLDLGTSVLFRSVEPPSGPGTFLDLGCGYGPIACALALAVPGARVHAVDVNDLAVSLTDRNARSLGVGDRVRASRPEEVDPDLRFDEIWSNPPIRVGKETLHEMLLTWLGRLSADGVAHLVVGRNLGADSLARWLGGQGYAATRVASAKGFRVLDVTG
>NZ_CP019400.1|WP_028700959.1|1167802_1168456_+|hypothetical-protein
MHSPAHPLQRLAALFSALLLCAAMLASGAASASAQGLPAATPQDCLKAGNVWVYVTYSDGSVVANSCATDFGTGEAALKSAGVDVGKDAKGMICSLDKKPNPCPAKFNGQYWNYYTSTDGKTFTYSQKAADQSKPVKGSIEAWCYNKASEKSCTPKTLSLTAEVPDASSSTPSSSASPAASSDSGGSSSSTAWGVGIVAAVIVIGVVVYLVVRRRRN
>NZ_CP019400.1|WP_028700960.1|1168464_1169778_+|ABC-transporter-permease
MPRLLERPADPVITDDGAGRRPSPGAGPLEARPGRAGGTNRPARTAGGAPTHPVAWWAWALATGAAVSMTTSPLLIVLVIAALALVVANRRSDAPWARSAGTYITLALSVIIIRMVFQILLGGSDTGTVLVRLPRIPLPLGVTLGGPVTAEGLATTGYDALRLATMLACFGAANTLADPRGVLKSVPAALHDISVAVVIALSVFPQLIVSVARVRRARRLRGGRAKGLRALTSILIPVLQDAVESSMDLSRAMESRGFGRTRDNRRVRPGTATGLVASMCGLVIGVYLLLTDPRWASAPRLSAQLVGAVVLGLSAIGAVAGLRSSGRRLRVTRYRPHRWTPRSIAVIGCGLLVVICTAALNSLAPAAVNPSTSPLEWPVLHPLMLGIAALVAAPAFLTSPPRRARAAQPRQRDLPAQPRQRDLPAQPRPNHPDRRGR
>NZ_CP019400.1|WP_028700961.1|1169774_1171487_+|ABC-transporter-ATP-binding-protein
MTPAIRLDDVSITLPDAEAPVLSHLDLAVQEGDLALVIGRTGAGKSTLLGALNGLVPHFSGGRLEGTVTVAGRDTRGHRPRDLADVVGVVGQNPMAGFVTDTVEDEIAYGMEQLGISPSIMRKRVEETLDLLSIADLRSRPLLDLSGGQQQRVAIASVLAAQPRILVLDEPTSALDPTAAQDVLASITTLVDDVGLTVVLAEHRLERVMHAADTVIWLPGDGSAVQGDPSEVLLKADVTPPLAQLSRLLGWDSVPLSVRRARRRVHDEERIPARSAPEPSEALSWSADPDDDVAELEDLCVSYGDLDAVDHVDLALQSGTVTALMGRNGAGKSSLMWAVQGATRSSGSVRVRSNPAPAARPASGAQEWSDPRTASPEQARRLVSLVPQAAADLLYLPSVGDECEQADRESEVAPGTTASILDRLGAGLPADRDPRDLSEGQRLALVLAIQLAARPTVVLLDEPTRGLDYAMKAQLARIVRGIADGSGPGLPGSPAAVLISTHDVEFAAASSDRTVVMADGQIVADGTTRSVCTSSPAFSPQMAKVFHPADVLTPDEVARALKEPAEGGSR
>NZ_CP019400.1|WP_071162058.1|1171483_1172326_+|ECF-transporter-S-component
MRVTALATPTSSRIILVLTAVLGLLAFTWPLLLNPGTQADYESRAPFLLAGVLALGVVILLSDLGSAGIDAKALAMLGVLTACGAALRPLSAGTAGIEFIFLLIILGGRVFGAGMGFLLGATTFLTSAVLTAGFGPWLPYQMVAAGFVGLGAGLLPRLSGWAETVMLAGYGFVTAFGYGWLMDFAFWPFSLGLSTSISYSAQASIGTNLKHFVMFNIATSMVWNLGRALTNVVLITLLGQPIMRVLRRAARKASWGSRGGPATRSTPARPAVDLPATRPE
>NZ_CP019400.1|WP_028700962.1|1172457_1173078_+|superoxide-dismutase
MAVYTLPDLDYDYSALEPHISGQIMQLHHDKHHQTYVTGANTALEKLEEARAKGDFGAINKLEKDLAFNLGGHINHSVFWKNMSPDGGGRPEGNELAAAIDEYFGSFEGFQKQFNEAAKGLQGSGWGILAWDALGQRLNTFQLFDQQGNLPTSQIPIVQLDMWEHAYYLQYQNVKANYVDAWWNVVNWADATARFDRARTQTAGLI
>NZ_CP019400.1|WP_028700963.1|1173256_1173946_+|glutamine-amidotransferase
MPTAIALRHVHFEDLGVIEPVLRDAGYGLRYVDVADSPGAIARLDPDLLVSLGAPVGADDVARYPWLTAESELLRRRADAGAPVLGICLGAQLLALAMGGHLVSGGSTEIGYAPIELTESGQESPLRHLEGVPVLHWHGDRFTTPPDAVRLAATRIDPDQAFSQGPTVLGLQFHVEADPGHIERWLIGHAHEMASVGVDPDRVRQDALLHGERLTAAARAMARDWLAGL
>NZ_CP019400.1|WP_028700964.1|1173946_1174594_-|hypothetical-protein
MKRSLLVLAASAAAVVGPVIMAAPGPHPAGQTVQGRDGRRRRIDSIDDVVAAVEESGAQGWELVNLATGIVHRMYTHYSTWHLWLTPAQSARRGQGHSQQYNLALGAVLRRLGVDVETVHAARVRMEHHPWYHTGHTWLRVTVGGKTLDVCASRPGNRAGEVGFLPVTEVRPLGPLTRLDSALALTPFVVTSVWKTWLTGRGVQRWLYRPFGQSA

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Crispr_ID: NZ_CP019400_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_4

1212729-1212865

Orphan

Consensus_repeat	Method
ATCAGGTGAGCGTCGCCGGCCGGCCGCTGCGGGTCCGGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_4

>merge|NZ_CP019400|4|1212729-1212865|CRISPRCasFinder
ATCAGGTGAGCGTCGCCGGCCGGCCGCTGCGGGTCCGGTCTGCGACCGCGCTCAGGACCAAGGCTCGCTGACCCCTCATGCGTCGGCTGCCGCCAGGATCAGGTGAGCGTCGCCGGCCGGCCGCTGCGGGTCGGGTC

>NZ_CP019400|4|4|1212729-1212865|CRISPRCasFinder
ATCAGGTGAGCGTCGCCGGCCGGCCGCTGCGGGTCCGGTC	TGCGACCGCGCTCAGGACCAAGGCTCGCTGACCCCTCATGCGTCGGCTGCCGCCAGG
ATCAGGTGAGCGTCGCCGGCCGGCCGCTGCGGGTCGGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015071259.1\|1222883_1223354_-\|30S-ribosomal-protein-S7	unknown	unknown	gnl\|CDD\|235398
NZ_CP019400.1\|WP_028700982.1\|1224118_1225105_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP019400.1\|WP_015071249.1\|1211190_1211862_-\|50S-ribosomal-protein-L3	unknown	unknown	gnl\|CDD\|234564
NZ_CP019400.1\|WP_028700981.1\|1223357_1223729_-\|30S-ribosomal-protein-S12	unknown	unknown	gnl\|CDD\|235355
NZ_CP019400.1\|WP_028701567.1\|1225247_1226618_-\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_CP019400.1\|WP_015071243.1\|1207523_1208342_-\|30S-ribosomal-protein-S3	unknown	unknown	gnl\|CDD\|234722
NZ_CP019400.1\|WP_076692565.1\|1212932_1214414_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NZ_CP019400.1\|WP_015071247.1\|1209995_1210304_-\|50S-ribosomal-protein-L23	unknown	unknown	gnl\|CDD\|235586
NZ_CP019400.1\|WP_015071256.1\|1219080_1220274_-\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
NZ_CP019400.1\|WP_015071245.1\|1208828_1209110_-\|30S-ribosomal-protein-S19	unknown	unknown	gnl\|CDD\|178985
NZ_CP019400.1\|WP_015071253.1\|1214517_1216242_+\|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	unknown	unknown	gnl\|CDD\|235424
NZ_CP019400.1\|WP_028700980.1\|1220592_1222689_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NZ_CP019400.1\|WP_015071242.1\|1207102_1207522_-\|50S-ribosomal-protein-L16	unknown	unknown	gnl\|CDD\|236411
NZ_CP019400.1\|WP_015071246.1\|1209125_1209962_-\|50S-ribosomal-protein-L2	unknown	unknown	gnl\|CDD\|236488
NZ_CP019400.1\|WP_076692640.1\|1217070_1218735_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378382
NZ_CP019400.1\|WP_015071241.1\|1206863_1207103_-\|50S-ribosomal-protein-L29	unknown	unknown	gnl\|CDD\|178971
NZ_CP019400.1\|WP_015071254.1\|1216306_1216834_+\|DUF664-domain-containing-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP019400.1\|WP_015071248.1\|1210300_1211194_-\|50S-ribosomal-protein-L4	unknown	unknown	gnl\|CDD\|184735
NZ_CP019400.1\|WP_015071244.1\|1208345_1208810_-\|50S-ribosomal-protein-L22	unknown	unknown	gnl\|CDD\|234793
NZ_CP019400.1\|WP_015071250.1\|1211873_1212185_-\|30S-ribosomal-protein-S10	unknown	unknown	gnl\|CDD\|179076

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015071259.1\|1222883_1223354_-\|30S-ribosomal-protein-S7	gnl\|CDD\|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	3.76968e-101
NZ_CP019400.1\|WP_028700982.1\|1224118_1225105_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.43244e-39
NZ_CP019400.1\|WP_015071249.1\|1211190_1211862_-\|50S-ribosomal-protein-L3	gnl\|CDD\|234564	PRK00001, rplC, 50S ribosomal protein L3; Validated.	1.03655e-129
NZ_CP019400.1\|WP_028700981.1\|1223357_1223729_-\|30S-ribosomal-protein-S12	gnl\|CDD\|235355	PRK05163, rpsL, 30S ribosomal protein S12; Validated.	4.95151e-84
NZ_CP019400.1\|WP_028701567.1\|1225247_1226618_-\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	8.43824e-26
NZ_CP019400.1\|WP_015071243.1\|1207523_1208342_-\|30S-ribosomal-protein-S3	gnl\|CDD\|234722	PRK00310, rpsC, 30S ribosomal protein S3; Reviewed.	2.558e-139
NZ_CP019400.1\|WP_076692565.1\|1212932_1214414_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NZ_CP019400.1\|WP_015071247.1\|1209995_1210304_-\|50S-ribosomal-protein-L23	gnl\|CDD\|235586	PRK05738, rplW, 50S ribosomal protein L23; Reviewed.	1.55389e-44
NZ_CP019400.1\|WP_015071256.1\|1219080_1220274_-\|elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NZ_CP019400.1\|WP_015071245.1\|1208828_1209110_-\|30S-ribosomal-protein-S19	gnl\|CDD\|178985	PRK00357, rpsS, 30S ribosomal protein S19; Reviewed.	1.83104e-62
NZ_CP019400.1\|WP_015071253.1\|1214517_1216242_+\|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	gnl\|CDD\|235424	PRK05347, PRK05347, glutaminyl-tRNA synthetase; Provisional.	0
NZ_CP019400.1\|WP_028700980.1\|1220592_1222689_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_CP019400.1\|WP_015071242.1\|1207102_1207522_-\|50S-ribosomal-protein-L16	gnl\|CDD\|236411	PRK09203, rplP, 50S ribosomal protein L16; Reviewed.	2.75928e-91
NZ_CP019400.1\|WP_015071246.1\|1209125_1209962_-\|50S-ribosomal-protein-L2	gnl\|CDD\|236488	PRK09374, rplB, 50S ribosomal protein L2; Validated.	0
NZ_CP019400.1\|WP_076692640.1\|1217070_1218735_+\|hypothetical-protein	gnl\|CDD\|378382	pfam10081, Abhydrolase_9, Alpha/beta-hydrolase family. This is a family of alpha/beta hydrolases which may function as lipases. This domain is the catalytic domain and includes the catalytic triad and the GXSXG sequence motif which is a characteristic of these enzymes.	5.35666e-142
NZ_CP019400.1\|WP_015071241.1\|1206863_1207103_-\|50S-ribosomal-protein-L29	gnl\|CDD\|178971	PRK00306, PRK00306, 50S ribosomal protein L29; Reviewed.	3.02733e-24
NZ_CP019400.1\|WP_015071254.1\|1216306_1216834_+\|DUF664-domain-containing-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	3.49998e-11
NZ_CP019400.1\|WP_015071248.1\|1210300_1211194_-\|50S-ribosomal-protein-L4	gnl\|CDD\|184735	PRK14547, rplD, 50S ribosomal protein L4; Provisional.	5.46939e-139
NZ_CP019400.1\|WP_015071244.1\|1208345_1208810_-\|50S-ribosomal-protein-L22	gnl\|CDD\|234793	PRK00565, rplV, 50S ribosomal protein L22; Reviewed.	3.24449e-53
NZ_CP019400.1\|WP_015071250.1\|1211873_1212185_-\|30S-ribosomal-protein-S10	gnl\|CDD\|179076	PRK00596, rpsJ, 30S ribosomal protein S10; Reviewed.	3.42547e-70

>NZ_CP019400.1|WP_015071250.1|1211873_1212185_-|30S-ribosomal-protein-S10
MAGQKIRIRLRAYDHEVIDSSARKIVDTVTRTGAKVAGPVPLPTEKNVFCVIRSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKLP
>NZ_CP019400.1|WP_015071249.1|1211190_1211862_-|50S-ribosomal-protein-L3
MTNERTVKGVLGTKLGMTQLWDENNRIVPVTVIQAGPCVVTQVRTPETDGYSAVQLGFGAVKAKNVTKPEAGHFERAGVTPRRHLVELRTADASEYTLGQEITADVFETAEVVDVTGTTKGHGTAGVMKRHGFKGLRATHGVHRKHRSPGSIGGCSTPGKVLKGMRMAGRMGNDRVTVQNLPIHSVDAERGIILVRGAVPGPKGSLLVVRSAAKQAAKNGDAA
>NZ_CP019400.1|WP_015071248.1|1210300_1211194_-|50S-ribosomal-protein-L4
MSENKTIDVLTAKGKKSGSVELPGDVFDVATNVPLIHQVVVAQQAAARQGTHSTKTRGEVAGGGKKPWRQKGTGRARQGSTRSPQWVGGGTVFGPQPRSYAQRTPKKMVAAALRGALSDRARDGQIFVLASLVESDKPSTKAAKSVLSNLGDLKKVLVVLDRSDEISWLSVRNLAEVHVIAADQLNAYDVLKADQLVFTRAALAAFVGEDAAEAEVPETDEADLHPFGADSFRGDNPPEGFDIKGNESSMKFHTPESPWYGRTIAEVWFATTQAAEAAGFVNAVKSDKGSAAEEDAK
>NZ_CP019400.1|WP_015071247.1|1209995_1210304_-|50S-ribosomal-protein-L23
MSDLKIRDPRDIILAPVVSEKSYGLLDQNAYTFLVKPTANKTEIKIAIEQIFDVKVTAVNTMNRKGKTRRTRAGVGKRKDTKRAIVTVAEGDRIDIFAGQGE
>NZ_CP019400.1|WP_015071246.1|1209125_1209962_-|50S-ribosomal-protein-L2
MGIRKHKPTTPGRRGSSGSDFVELTRSTPEKSLVTSKPKTGGRNNSGRITTRHIGGGHKQAYRIVDFKRYDKDGVPAKVAHIEYDPNRTARIALLHYADGAKRYIIAPDGVHQGTVVVAGVGADIKPGNNLPLRNIPVGTTVHAVELRPGGGAKMGRSAGASVQLVAREGKYATLRLPSGEMRMVDVRCRATIGEVGNAEQSNINWGKAGRSRWKGVRPTVRGVVMNPIDHPHGGGEGRTSGGRHPVSPWGKPEGRTRNKNKASSRLIVRRRKSGKKR
>NZ_CP019400.1|WP_015071245.1|1208828_1209110_-|30S-ribosomal-protein-S19
MPRSLKKGPFVDEHLAKKVDAQNEAGTHNVIKTWSRRSMVTPDMIGHTIGVHDGRKHVPVFVTEAMVGHKLGEFAPTRTFRGHVKDDKKARRR
>NZ_CP019400.1|WP_015071244.1|1208345_1208810_-|50S-ribosomal-protein-L22
MSNTENEPSRRRAALLGDRPGSFAIARHVRMSASKCRRVVDLVRGIDASEALDILKFQPQAAAEPVRKVVASAVANAEQTEGLRGDDLYISQAFVDEGITMRRIRPRAKGSASRILKRGAHITVVVEPKDARPEPKKAKKGRPTNVKTETEKGA
>NZ_CP019400.1|WP_015071243.1|1207523_1208342_-|30S-ribosomal-protein-S3
MGQKINPHGFRLGVTTDHKTRWYAEKQYAELVGEDDKIRGWLKKNLERAGLSSIEIERRSERVTIFLYAARPGIVIGRNGAEAERVRGELEKLTGKQIQLNILEVKNPETDAQLVAQGIAEQLAARVAFRRAMRKAQQSAMRSGAKGIRIKCSGRLGGAEMSRSEGYREGRVPLHTLRADIDYGFFEARTTYGRIGVKVWIYKGDVTGTRAERAAQKAARQAAQGSGRGRGGNRRGRGDRPDRGGRRRAEAAKAPAEAQAGKASSQPENAGA
>NZ_CP019400.1|WP_015071242.1|1207102_1207522_-|50S-ribosomal-protein-L16
MLIPRRVKYRKQHHPGRRGMAKGGTELAFGDFGIQALEPAYLTNRQIEAARIAMTRYIKRGGKVWINVYPDRPMTKHPAESRMGSGKGTPEWWIANIKPGRVLFELAGVPEEVAREAMRLAIHKLPMKARFISREGGEN
>NZ_CP019400.1|WP_015071241.1|1206863_1207103_-|50S-ribosomal-protein-L29
MAKLKAADLRALSGDELRAKVTELKEELFGLRFQSATGQLENSARLREVRKDIARVYTVLQERNLNIVDDPDAPKEAAE
>NZ_CP019400.1|WP_076692565.1|1212932_1214414_-|glutamate--tRNA-ligase
MTDSQHAPARTRVAPSPTGDPHVGTAYMALFDKAWARQTGGQFVLRIEDTDRNRLVEGSEQQIYDSLEWLGLGPDESPLVGGPYAPYKQSERLDTYRPYVDQLIADGHAYYCWCSSERLADLRKQRADAHSPETGYDRLCLGMTREERAKLPGFTETPVVRMHIPDDVELGFHDLIRGDVRAPHPDDQVILKADGFPTYHMAVVVDDHLMGIDTVVRGEEWISSTPKHLLLYKWLGWQAPQFAHMPLLRNTDKSKISKRKNPAARLMWFREQGYLPEALRNFLQLLAYPTLAEGQEMESYESFISRFRWEDISTGGPVFDTAKLDWLNGMYIRSLDAGGLADRVLAYAVEAGQLTDPSDDDVATLRAAMPLVQERLTLLSEAVPKLAFLLEPDEELGFDEDSVAKLKGDPTAITAAAIEALGDLEDFTAEPIQAALRAEICEAMGIKPRVAFAPIRVGVTGSRVSPPLFESMEILGRDSTLTRLRRFAETLAR
>NZ_CP019400.1|WP_015071253.1|1214517_1216242_+|glutamine--tRNA-ligase/YqeY-domain-fusion-protein
MAEPSSTPSSAPSTAPSIAPSDFIRDVVREDNAQGTYSGRVQTRFPPEPNGYLHIGHAKAIVTDFGIAESFGGVCNLRLDDTNPGTEETEYVQAIVDDIAWLGYTPGRVVHASDYFEQLYSWAQYLIEQGLAYVDDQDPETISAQRGGYGKPGVESPYRDRPAAESLDLLARMRIGEFPDGSRCLRARIDMQNENMWLRDPVMYRIRHMHHHSTGDEWKIFPTYDWAHGQSDAIEGVTHSLCSLEFNSHRPLYEWFLAHLPLEGPAPKQREFARLELTHTITSKRRLKKLVDDRLVDGWDDPRMPTLRGMRRRGYPAAAIRDFCTAIGTTRNNSVRAIEEFESFVRKELNRTAQRRMAVLHPLKLVLDGWPVDADGNPVVDHFEIVNNPENPDDGTRRVAFSGTLWIEQDDFREDPPRKYFRLSPGREVRLRGAYLVTATDVVKDAEGRIVEVHASYDPDSRGGTAPDGRKVKSTMHWVSAAHAVDAEVRLYDRLFTADIPGEATGEALDDLNPDSRQILTGCKLEAALADTDPGQVVQFERLGYFGVDPDSPMVFHRTVGLRDEWAHIQKRNG
>NZ_CP019400.1|WP_015071254.1|1216306_1216834_+|DUF664-domain-containing-protein
MSDATDILHDFVSRIRDGAARLCDGLAEEHATYQVNPGTNTICWLLWHSAREIDAQIHDAVGGAQLWEEWAGRLGLALPPARLGAGATGFGQSPEDVIYVVAPVADLLGYLTDVCDEADAIIKGLGPEDLGRVIDPAWNPPVTLSVRIVSILDDAVQHLGQAALVRGIAERASAA
>NZ_CP019400.1|WP_076692640.1|1217070_1218735_+|hypothetical-protein
MLRHASVGGLLGSLFGFWTALSPSLIPRTWWMILINVAMSMLFAYGVGHLIGYLLRRFSVLIDLQITASARAVRIIRWLGYAVVLAVTVSVWFWAIQQQRDVSRTVNLQRHFWLTQIFGALTGILAFVAVLLLIRTISHGLRRLYSGVHRFITQPVLATSVFVIALVLALLATNNVVVRTAANAVAHQMETVNRRTTEGVHRPTSPLRSGGPGSTRSWASLGRKGQDFVASGPTAAQIAGTTGKPAIEPIRAYAGLPVDRDFTEAARAVLAELIRTRAFDRKVLVIYNTTGSGWVEEWSVSAVEYLTGGDCATASMQYSYLGSPGAFLLDRESPKEGAKALFRVIHDYWAALDPAHRPKLYTSGVSLGAYGGQSAFKEADDMMAKVDGAVWVGSPGITPIWESLTDARRQGSPEIAPVIGSGSHIRFIPGIRYIDRDRWGARYPAWKGPRIAYVQHSSDPVTWWQPDLIWREPDWIRERAGIDTNPRISWSPWSTFWQVTADMAIAVSVPGGHGHSYHQELIWVWSSVLGTDQITEGQKQSIAKDLPKSIKGTD
>NZ_CP019400.1|WP_015071256.1|1219080_1220274_-|elongation-factor-Tu
MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAISKVLHDKDPELNPQTEAFDMIDKAPEERQRGITISIAHIEYQTESRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPAIVVALNKCDMVDDEELIELVEMEVRELLSAQEFDGDNCPVVRVSAFQALQGDEKWTKSILELMDAVDEYIPTPTRELDKPFLMPIEDVFTITGRGTVVTGRVERGIVKTGDEVEIVGIRDTTKTTVTGVEMFRKILDEGEAGDNIGVLLRGTKKEDVERGMVLSKPGTTTGHTEFKGQVYVLKKDEGGRHKPFFSHYSPQFYFRTTDITGTVELPEGTEMVMPGDNTEMTVELIHPIAMEEQLKFAIREGGRTVGSGRVTEILK
>NZ_CP019400.1|WP_028700980.1|1220592_1222689_-|elongation-factor-G
MAKTIDLHNVRNIGIMAHIDAGKTTTTERILYYTGKSYKIGEVHDGAATMDWMEQEQERGITITSAATTTFWHDVQINVIDTPGHVDFTVEVERALRVLDGAVAVFDGVAGVEPQSMTVWRQATRYGVPRICYVNKMDRTGASFEHCVTTIKERLHAIPVLLQLPIGAEENFLGIIDLIEMNAKTWRGETELGQHYETEAIPAELKDAAEAARAEMMETVAENDEEFMELYLDDPDSITNDQLKAAIRRGVLANAFTAVTCGTSFKNKGVQPLLDAIVDYLPSPEDVPAIEGFKPGDESVELERKPTEDEPLSVLAFKIASDPHLGKLTYVRVYSGVLKAGEQVLNATKGKKERIGKIYLMHANKRQEVDEMGAGMIGAVMGLKDTTTGETLCDPNAPIVLESMDFPNPVIEQAIEPKSKADQEKLGVAIQRLVEEDPTFRVHTDEETGQTIIAGMGELHLDVFIDRMKREFHVEANIGKPQVAYRETIHKKVDKYEYTHKKQTGGSGQFARVIISIEPTEPGTGYEFVNAVTGGRIPKEYIPSVDAGVQDAMQFGVLAGYPMEDLKCTLLDGAYHEADSSEMAFKIAGSMAFKEAARKAQPGILEPLMAVEVTTPEDYLGTVIGDLNARRGQIQEMVEEHGNKVVRALVPLAEMFGYVGDLRSKTSGQASYSMEFDSYGETPSTVADEIIAKANGGK
>NZ_CP019400.1|WP_015071259.1|1222883_1223354_-|30S-ribosomal-protein-S7
MPRKGPAPKRPIMVDPVYGSPIVSQLVSKILKDGKKTVAQDIVYGALEGCRAKTNTDPVQTLKRALDNIKPSLEVKSRRVGGATYQVPVEVKPARATTLSMRWLVAFSRERREKTMAERLMNEILDASNGLGASVKRREDTHKMAEANRAFAHYRW
>NZ_CP019400.1|WP_028700981.1|1223357_1223729_-|30S-ribosomal-protein-S12
MPTIQQLVRKGRTDKLSKNSTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLSSGIEVTAYIPGIGHNLQEHSMVLVRGGRVKDLPGVRYKIVRGSLDTQGVKGRKQARSRYGAKKEK
>NZ_CP019400.1|WP_028700982.1|1224118_1225105_+|Gfo/Idh/MocA-family-oxidoreductase
MIGLATIGTSTITRNLLDAVAEDPRVRHTVVCSRDAARGAAFAARSPTRADSPRVVTTIDDLVAADVDAVYVASPNIAHHSQALAALEAGKHVLVEKSACVTAAGWQQLVDAAGRHGVALLEANRNSIWHPGTAELRDALPRIGRVRMSQLSYCQRSSRYDRFLAGQLPGIFDPRMAAGALMDIGTYPLETMVELFGVPEAFSTDAVRLRNGIDGAGSLLARYDGHLCSVVWSKISDSPGPSVIQGEDGTITVDAVEDPGVIEVRTAGTVRTTRIPHRRVRDMAHELSAFVEATEDPTRCALPHRWTSERLALMEQIRDRIGLELPGR
>NZ_CP019400.1|WP_028701567.1|1225247_1226618_-|IS1380-family-transposase
MQVSHEPVTAPTPVFDEDHLVAAGGLPAILGLAEQADFISLLAGRLTVDCPNAPLKARSLVAGMLAGADDIDGTGILRTGGTPKVMGGVRAPSTLGTFLRSFTHGHVLQLGAVNRKLLEHLAPVVPGLFGADPLITVDLDDTIRELHGYRKQGVAYGYNKVKGLNAILAVVSSDSCPPVITGAGLRRGNVKSGDHAAWHATRSITLARTVRPGTQILGRADSAFCTCETIHAFADHGCWFSVTIPAWPTVTAAISGIDEQAWTPIRYPHAVIEPETGELISDAEVAETPFTAFVSHPKDEQVSCRLVVRRVKRLNPAGQDPLVESYRYHAFITNSDLDTVEADRRHRDHAIVEQVIAELKAGPLAHLPSGRFTANAAWLACAVIAFNLSRAAAHAAGMSTARMPTITRRLIMIPARIAHRARRRYLHMPRRWPWATQFTRLWTTATAVGPPLALAS

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Crispr_ID: NZ_CP019400_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_5

1703360-1703498

Orphan

Consensus_repeat	Method
GCAGCACCCGGACGCGGACGCAGACCTGAACCGCAGCGCCGGGCCCGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_5

>merge|NZ_CP019400|5|1703360-1703498|CRISPRCasFinder
GCAGCACCCGGACGCGGACGCAGACCTGAACCGCAGCGCCGGGCCCGCGACGCCGACCCCCTCACCGGGCCTGTCACCGCCCGAGCAGGCAGCACCCGGACGCGGACGCAGACCTGAACCGCTGCGCCGGGCCCGCGAC

>NZ_CP019400|5|5|1703360-1703498|CRISPRCasFinder
GCAGCACCCGGACGCGGACGCAGACCTGAACCGCAGCGCCGGGCCCGCGAC	GCCGACCCCCTCACCGGGCCTGTCACCGCCCGAGCAG
GCAGCACCCGGACGCGGACGCAGACCTGAACCGCTGCGCCGGGCCCGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015071716.1\|1710456_1710660_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015071697.1\|1692936_1693611_+\|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl\|CDD\|223868
NZ_CP019400.1\|WP_015071711.1\|1705424_1706105_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP019400.1\|WP_015071718.1\|1711761_1711992_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015071707.1\|1701771_1703280_-\|potassium/proton-antiporter	unknown	unknown	gnl\|CDD\|235410
NZ_CP019400.1\|WP_015071700.1\|1695427_1696183_+\|Branched-chain-amino-acid-export-protein-large-subunit	unknown	unknown	gnl\|CDD\|224215
NZ_CP019400.1\|WP_015071698.1\|1693761_1695105_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NZ_CP019400.1\|WP_015071704.1\|1699085_1700714_-\|DUF853-family-protein	unknown	unknown	gnl\|CDD\|283518
NZ_CP019400.1\|WP_015071717.1\|1710660_1711617_-\|drug/metabolite-DMT-transporter-permease	unknown	unknown	gnl\|CDD\|183277
NZ_CP019400.1\|WP_015071701.1\|1696179_1696485_+\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377512
NZ_CP019400.1\|WP_015071713.1\|1707452_1708976_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP019400.1\|WP_028700875.1\|1706197_1707121_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP019400.1\|WP_015071710.1\|1704786_1705428_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP019400.1\|WP_015071705.1\|1700846_1701140_+\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|227737
NZ_CP019400.1\|WP_028700876.1\|1703632_1704790_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP019400.1\|WP_148279581.1\|1696633_1697365_-\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|367957
NZ_CP019400.1\|WP_015071706.1\|1701152_1701698_+\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163
NZ_CP019400.1\|WP_081583496.1\|1709330_1710200_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|366837
NZ_CP019400.1\|WP_051143581.1\|1712184_1713255_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176237
NZ_CP019400.1\|WP_015071703.1\|1697618_1698794_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015071697.1\|1692936_1693611_+\|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	2.89184e-33
NZ_CP019400.1\|WP_015071711.1\|1705424_1706105_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	4.42462e-51
NZ_CP019400.1\|WP_015071707.1\|1701771_1703280_-\|potassium/proton-antiporter	gnl\|CDD\|235410	PRK05326, PRK05326, potassium/proton antiporter.	0
NZ_CP019400.1\|WP_015071700.1\|1695427_1696183_+\|Branched-chain-amino-acid-export-protein-large-subunit	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	8.00143e-36
NZ_CP019400.1\|WP_015071698.1\|1693761_1695105_-\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	1.08862e-05
NZ_CP019400.1\|WP_015071704.1\|1699085_1700714_-\|DUF853-family-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_CP019400.1\|WP_015071717.1\|1710660_1711617_-\|drug/metabolite-DMT-transporter-permease	gnl\|CDD\|183277	PRK11689, PRK11689, aromatic amino acid efflux DMT transporter YddG.	1.73646e-113
NZ_CP019400.1\|WP_015071701.1\|1696179_1696485_+\|AzlD-domain-containing-protein	gnl\|CDD\|377512	pfam05437, AzlD, Branched-chain amino acid transport protein (AzlD). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain.	5.60609e-10
NZ_CP019400.1\|WP_015071713.1\|1707452_1708976_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.39204e-41
NZ_CP019400.1\|WP_028700875.1\|1706197_1707121_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.08106e-128
NZ_CP019400.1\|WP_015071710.1\|1704786_1705428_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	9.18235e-39
NZ_CP019400.1\|WP_015071705.1\|1700846_1701140_+\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	1.15513e-09
NZ_CP019400.1\|WP_028700876.1\|1703632_1704790_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	7.40873e-129
NZ_CP019400.1\|WP_148279581.1\|1696633_1697365_-\|DUF559-domain-containing-protein	gnl\|CDD\|367957	pfam04480, DUF559, Protein of unknown function (DUF559).	0.0002829
NZ_CP019400.1\|WP_015071706.1\|1701152_1701698_+\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	1.66934e-15
NZ_CP019400.1\|WP_081583496.1\|1709330_1710200_+\|HNH-endonuclease	gnl\|CDD\|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	2.5221e-13
NZ_CP019400.1\|WP_051143581.1\|1712184_1713255_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	6.85782e-157
NZ_CP019400.1\|WP_015071703.1\|1697618_1698794_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	3.2424e-120

>NZ_CP019400.1|WP_015071707.1|1701771_1703280_-|potassium/proton-antiporter
MPLFDLDLLVGAAVALLAVFAARVSSRLGLPALLLFLLVGMMLGPLGFGIQFSDAGMAHGLGFAALVLILAEGGLSTKWSSIKPALGVAGLLATVGIGGSIALMAVFAHFALHLPWTVAVLLGAVTAPTDSAAVFSVLRGVSIPTRLRSILEAESGLNDAPTVLVVIAMTGLAAGHQPSGGIPGLIGSIVVELAGGILLGVVMGWIAVRITRRVSLPSSGLYALAALAWAVLAYGVGVWVGVSGFASVYVASVVIGNGRLPYRNATRSFAEGVGWMAQIGLFVMLGLLADLDRLTWTEVLEGVVAGLFLTVIARPLSVALCASWFKMPPRHQAFVSWAGLRGAVPIILATIPLAARIPEAGKLFDIVLVFVVVFTCIQGPTLAAAGRLLGLVDPDAATDVDIEVAPLDEIDAVLLQVHVPVDSHLIGVTVRELRLPRNAFISLIIRADESFVPHASTALMRADELLLVTPEAERRQVEERLTEIGRGGRLARWNGLRVKAEE
>NZ_CP019400.1|WP_015071706.1|1701152_1701698_+|LytR-C-terminal-domain-containing-protein
MTQSARHYLKLVATPITLLVLLAIIVVGFWYGWKALTAPFGPKAVPCVNTNVGKSLTTKSIELDVVNGGHTRGLAKQVANQLTAKGFSVTDTGNTDERVKQTVIVGVAKDSPEVKLVSAFFPKSTVRVDTTRVDHSVTVMVGENYGGFNAKAPTSLAVSGPVCLPSPSATPSPSGSATPAS
>NZ_CP019400.1|WP_015071705.1|1700846_1701140_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MIFKRVGDSRPYPDHGYVQKQWSEIPPVQVRLDQLVTTKSTLDLGSLLEDDSTFYGDLFAHVVAWRGELYLEDGLHRALRAALQQRQTVHARVLELH
>NZ_CP019400.1|WP_015071704.1|1699085_1700714_-|DUF853-family-protein
MSQTPRESEPVAEAVDDALIDAITTGYTFEEPALDLGALSTDAGAVPSARVRIPLSMVNRHGLVAGATGTGKTKTLQVMAEQLSAAGVPVFAADIKGDLSGLASAGEASDKLAARTAKLGQQWAATGYPVEFYALGGAGRGIPVRATVSSFGPVLLSKVLSLNDVQESSLGLVFHFADKAGLPLLDLKDLQAVLNHLGSEEGKADLKGIGGLSSATLGVIIRKIVTFADQGAAEFFGEPEFDTADLMRTAADGRGIISLLELPDLADRPALFSTFLMWLLADLFSDLPEVGDAERPKLVFFFDEAHLLFDDASKAFLDAIAQTVRLIRSKGVGVFFVTQTPKDVPDDVLAQLGSRVQHQLRAHTPNDAKALKQTVATFPKSSYDLAEVLQSLGIGEAIVTVMDPDGAPTPVARTKIFAPTSLMAPTPDAQIDAAVKGSSLYSKYAEAVDRDSAYEMLARKLADGAQRAAEEKRAAEQQAAQEQAAEQQARQAPRAEARPAGRGRQEKSVVDKVLGSSVVRQFARSAGREIVRSLFGTARRRS
>NZ_CP019400.1|WP_015071703.1|1697618_1698794_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MTQFDFDSPTTDWLKARGTARWHDVADGVIPLWVAEMDFPVAPPVQAAIQDIVTKQAYGYPRDNGLKEAWANWAKNHQGLEVDPAKVTVLPDVLTGVRLALRTFSPAGSPLVLPTPAYMPFWDVPGLIGRRIISVPMITGADGRSTFDLEGIGRAFAQGARSIILCSPYNPLGRVFTETELLGLSEVVEEHGAFVVADEIHGPLVPAGGEAQGRTVPYASVSEKAAAHSINLMSASKSWNLAGLLTAVGTLFTDENQRLWKKEVHELETEGASTVGMAANLAAFTSGQPWLDEANEYIHANAVWLHDELARELPQAHFTVPEATYLGWIDFRDYGLPDNAGTWLLKNARIRLNDGPTFGPGGEGHARINLATPRYLLVEALGRMADAVNSR
>NZ_CP019400.1|WP_148279581.1|1696633_1697365_-|DUF559-domain-containing-protein
MVDDPDAWMVAAHQWRPSAIITGGAALRALHGLPIGFPIVVADHLDRASTERVRFLRTRFPPELLIDEGAGAFTVDEVSVLVCAALGDFAPVCHALREGWVTLDTLHEAAALLPPRSWLGMAAPELLRDLRDTPWSVAELLVQRHLRKARITGWVANPTLIIAGKEYEPDLLFRRRRLIVEVVGLEFHSGKEAVRRDISRAADLLAAGYRIVSVTADMVKFEPERVLGLIASQLGWYELRGST
>NZ_CP019400.1|WP_015071701.1|1696179_1696485_+|AzlD-domain-containing-protein
MSIFLMIPVAAAITFGLRFIPLLGIDRLKGHDSVERLSALMPGGIMIILVAYTLVDPGREGPLWTWLVAIAVTVAVHLWRRSPLITMLTGIGAYALLAALV
>NZ_CP019400.1|WP_015071700.1|1695427_1696183_+|Branched-chain-amino-acid-export-protein-large-subunit
MPETASTPTRSGWIDDLRWAVHASGPVAMGYVPLGMALGALVVNLGLHWWLAPVMATAVYAGSMEFLLAGFLVSAPGLASVALATLAVNFRHVFYPLAYPTHLLGRPWQKVLGAWQLTDEMYALMAGGTRPQNSRQVLMLSSVTQFWWVSGTVLGTAIGNLVPAGFRGLDFAMTGLFIALALNFFLSSAAWRVAGYAAVGIGAALLLPGPFLAWSLSVFTLCCLAEVWVVERRDAGPDDAEGQDDERREAR
>NZ_CP019400.1|WP_015071698.1|1693761_1695105_-|hypothetical-protein
MDISAMDPQSIQQLFDAEVVGPEGEAIGTVEQIFADDVTGAPTFVTVKDARTGAESFLPVSGADYNGRRVEVPFSQDVVQAAPSANGGEDLSPEREAEVYGYYGIRAPRRSRQEEAEPDDSWGEDAEFTPAQEPSGETQSDEAEGDDGASDEQDEAATDEPGEQDEAVTDEPGDPDEAAPAVVPEDATAQTVLGQDEPQFEPTEEAEDPATEFRSDVEIDEETDPAVPDEASADENPAEETAVLAGGSFPGAATSAGLVTAGSAAAAGSEPDRSDDAIATGDPDAVLDADDEGLAAGTEVDDAALSTDRLDGESPEAAREDEAESPDDEADSDEPDEDEAGGDASEADDQSESDDRSAASAIPGLPAGATLRKYVVTEMVTVQVPVRREVVCWVDAEGGVHELEPVEAPEATQKKDLHDPATWWFGSEAASETGDDKGPEHEEGPES
>NZ_CP019400.1|WP_015071697.1|1692936_1693611_+|septal-ring-lytic-transglycosylase-RlpA-family-protein
MTSTRGAHTSLRRLATLAATTGLVFAGATVGQAHAAPQQAPSRTVPAAGSVVYKKWAWATVNVNVHKWANASSANVVVLGKGRALGVITTNTAKGWVKVNYKGQAGYIQTRYVKIASTGVNPLKKAASTSGAVGTCKASYYGEGSRTANGERFNPSAMTAAHKTYKFGTKLKVTNKANGKSVVVRINDRGPYVSGRCLDLSTGGFKKIASTSAGVATVTYQVVR
>NZ_CP019400.1|WP_028700876.1|1703632_1704790_+|ATP-binding-cassette-domain-containing-protein
MISFTDVVKVYADGTRAVDGLPLEAPTGRITVLVGPSGCGKTTSLRMINRMIEPSSGTIAIDGRDVASLNPDELRRGIGYVIQSGGLFPHRTVVDNIATVPRLLGRSRRQARSEAMELLERMGLDADLAGRYPAQLSGGQQQRVGVARALAADPPVMLMDEPFSAVDPQVRAQLQDEFLRLQSELGKTIVLVTHDIDEAIRLGDEVAVLRPGGTLAQLDPPSRLLADPADDFVADFLGRDRGYQRLGFTPAPPLPLADETTVALGTEAEEARRRAAAQSPAWRRPWLLVVDEQNSPLGWVRPESVTGQVERTDLHRGGTVARADGSLRAVLDAALSSPARRGVVVDGHGGLLGTVLAQDVLALIEDDGDDGAGPEAPGADGGEPS
>NZ_CP019400.1|WP_015071710.1|1704786_1705428_+|ABC-transporter-permease
MSWFLSHTDQVWGLLGHHAALAALPLLIGVLVALPLGWLARRHRALYTPMVAGAGLLFTIPSLALFILMPLILGTGILDPTNVVVALSLYTLALMVRTVADALGSVPPQVTSAARAMGIGSLRRFLTVELPLATPAISAGMRVAAVSNVSIVSVAALIGVPQLGSLFTDGFNRTFVTEIVVGLVACIALALAFDAVIVVATRLVTPWTRGRAS
>NZ_CP019400.1|WP_015071711.1|1705424_1706105_+|ABC-transporter-permease
MNLLWDWLANPVNWAGPDGVWARLAEHLAYSGAALLIAAAIGIPLGLWIGHTGRGRAVTVNLVNGMRAVPTLGLLFAAVLVIGPRLHGDAAFQVPAIVVLVILATPPILAGTYSGIDAVPPDARDAARGMGMTPGQVLGRVEVPCALPLIFSGVRSAALQVIATAILAAYVGLGGLGYFLQLGQGSRDYGMMAGGAVLVALLALAVDLILAGVQRLTLSPGLRTRT
>NZ_CP019400.1|WP_028700875.1|1706197_1707121_+|ABC-transporter-substrate-binding-protein
MRHRRVLAAALAVVTTMAIAGCGGSSDPLAEGSASGSASGSGGIVVGSANFPENELLADIYAGALNHQGVKASTKLNIASRETYIPALKKGEINLIPEYTGNLARYFDKSASISDSATADASLKKALPKGLTALTPAPAENKDSMVVTKQTAEQKKLKSISDLSASASGMVLGAPPEFKTRVDGVSGLKREYGLTFKEFKPLDEAGPLTVQALKNGQVQVANLFSTDPNIAANGFVVLDDPKNLFGAQNIVPVMTSSKASPKATKALDAVSAKLTTPVVQKLVEKVVIDKQDASAVAQQWLKANDLG
>NZ_CP019400.1|WP_015071713.1|1707452_1708976_+|serine-hydrolase
MITAEEIDQRAIGRIVEEAVSGWSICAPTWAAAVFDRSGVIAFASAASQGFERPARGDIFRIASMSKSFLVACMLLLVERGDLDLDAPVDRYIPSFQTPSTDVVTVKMLISNASGLPEDNGWSDHNLDLPRAEFIALLRKGFHFTEPPGQAYQYSNVAFTVASMILEIVSGERYETFLNHEILEPLGLDSTRYRAGDDPQSAPLARGFSTFDRGISWVAREFAEPGATAPVGALFSTVDDIAQWSAWLSAPFQADAHGGGDVARPRLSLLSGASRARMQRIHTPIPSIAGRWTSPRDDAAGYGLGLFVEHDSRFGPIAQHSGGLPGLSANMRWQLDSGIGVVAYATSEGQPVSDRAADLLDAVLRARDVPARHIRLWPQTFEAARRIDSMLRGGADHRKVSDLLAGSVFADMPAEIRRNQFEAAVARAGGLSHDVAPLADRALWCVSAAQLVWRLPCARSDLQVRIELAEVARQPVQRLVIEPLGAELAGLPADRDLVVRHHRPVLP
>NZ_CP019400.1|WP_081583496.1|1709330_1710200_+|HNH-endonuclease
MKRYFSGEVFQAHLKELSSVVTEHNEIAAYAAEIRAGGQFGLGTSGTGSRSSLATFENTSRHDYRRDRNVAHYQALNVHNCSLQVVRNASADPLKYLIKYFGVEATEEGLAQVEKLGETISRLENAVNNLKTREADITGEFNPPKFILKHYEKQFTERVGVNLSPISVPCPEYVFEYVSAGGNSSQRTTVKLNTPTIDGLIEALSERIRRRRSAAGQRALMTARFREEIKRRDDYTCRYCSVSLDDEPHLLLEVDHIVPVSRGGLSTEDNLQTLCWRCNRSKSNKMIDA
>NZ_CP019400.1|WP_015071716.1|1710456_1710660_+|hypothetical-protein
MTPQAHGQQEELAQRWQDVATAMWRRAVDQRRDNAGARDAALAQVAAQTAANVLAGLHAPAPEDLIY
>NZ_CP019400.1|WP_015071717.1|1710660_1711617_-|drug/metabolite-DMT-transporter-permease
MRAGSIVVWKRGLMASTPQAVQSRRATAIGVAAILLWSGIVGLIRVTTQHFGATLGPSLIYTLAAALLWLTRRPKSLRGFSARYLLLGGGMFVIYEVALAMAVGLSDDAHQTIEVSIVNYLWPTLTVALAAVVNRRERRPGLLIIPGVLLATVGVVGAVGGEAGLSPTRIAANVMSNPLPYLLSLMAAAVWAAYSVFSPRLAGGRDGITVFISGVAAALWIVNLVSPAPVGDITASGVAGLIGAAAVIASGYASWNVGILHGNITLLASASYATPVLSTAVSSLLLGAVLPLTFWGNVLLVVAGSLAGWWATRRTGRR
>NZ_CP019400.1|WP_015071718.1|1711761_1711992_-|hypothetical-protein
MMKTSELFATQLVAFQAARDALDRRADDDGVDPPAGRITRNGAIVETTSAELTDAVDSGDLPGIQGPPQIGSTPRP
>NZ_CP019400.1|WP_051143581.1|1712184_1713255_-|NAD(P)-dependent-alcohol-dehydrogenase
MWTSRELLDLRGDTRAEGRTVFTYRFDHLDGLDSLTRHEEESPSPQRGEVLVRVRSVALNYRDIAIPLGRYVWDARPGLIPCSDAAGEIVETGDGVDSFEPGDRVVSCFHSRWFGGRPPANLMLDTYGSGKDGWLTQYAVVSQDAVVKIGDELSFGEASTLPCAGVTAWNALSGPSPIRPGDTVLTQGSGGVSIFAIQLAKALGASVIATTTSADKEALLRDLGADRTINTRDTPEWGGVVRDMTGDGVDRIVEVVGPQTIHQSLAAIRWNSEIVLVGFLSSTGPDINYFTLKGSGASIRSIGVGDRTMLEELIRVVAAAGIRPVIDSTYSFNEAPQAFRHLADGRHTGKIVIELT

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Crispr_ID: NZ_CP019400_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_6

1808454-1808566

Orphan

Consensus_repeat	Method
ACAACGTCACCATCACCGATTCGACCGTCTACACCTGCCCGA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP019400_6

>merge|NZ_CP019400|6|1808454-1808566|CRISPRCasFinder
ACAACGTCACCATCACCGATTCGACCGTCTACACCTGCCCGAGGAGTGCCCGATGAATGCCAGCTCAGACAACAACGTCACCATCACCGATTCGACCGTCTACACCTGCCCGA

>NZ_CP019400|6|6|1808454-1808566|CRISPRCasFinder
ACAACGTCACCATCACCGATTCGACCGTCTACACCTGCCCGA	GGAGTGCCCGATGAATGCCAGCTCAGACA
ACAACGTCACCATCACCGATTCGACCGTCTACACCTGCCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015071808.1\|1819829_1820513_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP019400.1\|WP_028700676.1\|1807449_1807662_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_148279583.1\|1802173_1804753_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NZ_CP019400.1\|WP_154662035.1\|1807684_1808368_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015071806.1\|1817939_1818848_+\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782
NZ_CP019400.1\|WP_081685354.1\|1812287_1813040_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|182593
NZ_CP019400.1\|WP_015071794.1\|1804746_1805070_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP019400.1\|WP_015071807.1\|1818840_1819833_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP019400.1\|WP_015071796.1\|1805626_1807102_-\|Family-2-glutamate-cysteine-ligase	unknown	unknown	unknown
NZ_CP019400.1\|WP_015071795.1\|1805086_1805587_+\|activator-of-Hsp90-ATPase-1-family-protein	unknown	unknown	gnl\|CDD\|176910
NZ_CP019400.1\|WP_028700666.1\|1820517_1821240_-\|VIT-family-protein	unknown	unknown	gnl\|CDD\|153123
NZ_CP019400.1\|WP_028700684.1\|1799532_1800189_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	unknown	unknown	gnl\|CDD\|132048
NZ_CP019400.1\|WP_076692575.1\|1813748_1815443_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP019400.1\|WP_154662034.1\|1811985_1812144_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_081583500.1\|1811035_1811959_-\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|224629
NZ_CP019400.1\|WP_028700679.1\|1798736_1799483_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP019400.1\|WP_148279585.1\|1815895_1817419_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|99795
NZ_CP019400.1\|WP_028700678.1\|1800997_1801897_-\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	unknown	unknown	gnl\|CDD\|270223
NZ_CP019400.1\|WP_028700669.1\|1817421_1817943_+\|FMN-binding-protein	unknown	unknown	gnl\|CDD\|226484
NZ_CP019400.1\|WP_015071791.1\|1800185_1800989_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	unknown	unknown	gnl\|CDD\|223836

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015071808.1\|1819829_1820513_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.29703e-53
NZ_CP019400.1\|WP_028700678.1\|1800997_1801897_-\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	gnl\|CDD\|270223	cd01002, PBP2_Ehub_like, Substrate binding domain of ectoine/hydroxyectoine specific ABC transport system; the type 2 periplasmic binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that involved in uptake of osmoprotectants (also termed compatible solutes) such as ectoine and hydroxyectoine. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.12816e-81
NZ_CP019400.1\|WP_148279583.1\|1802173_1804753_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NZ_CP019400.1\|WP_015071806.1\|1817939_1818848_+\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	7.85249e-36
NZ_CP019400.1\|WP_081685354.1\|1812287_1813040_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	2.7428e-15
NZ_CP019400.1\|WP_015071794.1\|1804746_1805070_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.87209e-15
NZ_CP019400.1\|WP_015071807.1\|1818840_1819833_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.0184e-37
NZ_CP019400.1\|WP_076692575.1\|1813748_1815443_+\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	1.12227e-13
NZ_CP019400.1\|WP_015071791.1\|1800185_1800989_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.05368e-70
NZ_CP019400.1\|WP_028700684.1\|1799532_1800189_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	gnl\|CDD\|132048	TIGR03003, ectoine_ehuD, ectoine/hydroxyectoine ABC transporter, permease protein EhuD. Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.	6.58892e-75
NZ_CP019400.1\|WP_028700666.1\|1820517_1821240_-\|VIT-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	1.17894e-98
NZ_CP019400.1\|WP_081583500.1\|1811035_1811959_-\|restriction-endonuclease	gnl\|CDD\|224629	COG1715, Mrr, Restriction endonuclease [Defense mechanisms].	1.31175e-89
NZ_CP019400.1\|WP_028700679.1\|1798736_1799483_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	9.34602e-140
NZ_CP019400.1\|WP_148279585.1\|1815895_1817419_+\|oxidoreductase	gnl\|CDD\|99795	cd06198, FNR_like_3, NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	4.3573e-47
NZ_CP019400.1\|WP_028700669.1\|1817421_1817943_+\|FMN-binding-protein	gnl\|CDD\|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	3.75958e-15
NZ_CP019400.1\|WP_015071795.1\|1805086_1805587_+\|activator-of-Hsp90-ATPase-1-family-protein	gnl\|CDD\|176910	cd08901, SRPBCC_CalC_Aha1-like_8, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.96802e-52

>NZ_CP019400.1|WP_154662035.1|1807684_1808368_-|hypothetical-protein
MDKLTGMDPGSLADWISAIATVAATVAAVFAGFYAYKALRIEQAGDAERHEDRRRAQAEQVNAWAEHIRPDPRSPGFNTTGSNGVVQNSSGHDGVRLVVKLQNLSNAPVYAVRIGFILGRRPREGEVPDGVHPPKRPLYADWEFLLPPTDEPLVLVEFNWRAMQAWQEWRLRQESMNHMDARPYVELTFQDGSGTWWLRDARGRLTDISENDAVHRFEYPNAAGPLR
>NZ_CP019400.1|WP_028700676.1|1807449_1807662_+|hypothetical-protein
MRPCPSCGSYKRIELAPSFYECTALVAPSKDSATGEPVPCGVHYLDTSDRLTPVPLTPFGTRFDSLITGS
>NZ_CP019400.1|WP_015071796.1|1805626_1807102_-|Family-2-glutamate-cysteine-ligase
MGRDTSSTTYTRSERTRYRLKLHENLETFARYLPRADFSDAATIGIEMEINLTDADGHPVRRALDALDAIGNDEFQTEIGAHNIELNLPAVPVAGRGLEHLEDVARQRLHDARIAVEEIGVELVPVGMLPTLTEDDLRSEGWRNPENRYKALDNAILEARGEDIHIHVQGDDEIDLTIDSIAPESACTSAQLHLQVPPSQFAAAWNAAQAIAGPQVAVAANAPFFLGQAGWVENRIPVFTQATDTRPPEFANQNVRPRVWFGERWINTVFDLWEENVRYFPAILPESRQAAGQALLTEGAAPRLHELVLHNGTIWRWNRPVYDPGSGGRPNLRIENRLLPTAPTVLDQISDAAFFYGLVGRLVHDPRPLWSRMPFSDARANFQACAKDGLTADVVWPGLGSVPVAELVGEVLIPLAREGLVIQEVDDDLIDRYLSVIEARAHTGHNGAAWQRRMVEQLESVWMGREEALAEMTRRYRQNQVTGKPVHTWDI
>NZ_CP019400.1|WP_015071795.1|1805086_1805587_+|activator-of-Hsp90-ATPase-1-family-protein
MTDDNTPTSPDDEPLTELSFTVSGRVSRPVAEVYEAVADPDQLSHYFTTGGAHGRLESGATVSWDFHDFPGRFPVTVVEATPPRRIEIRWGADKPEDGLTETTVVFEFSPIDEGRRTLVTITESAWRATSPGARNAFGNCEGWTGMLAALKVWVEHGINLREGFYA
>NZ_CP019400.1|WP_015071794.1|1804746_1805070_-|winged-helix-turn-helix-transcriptional-regulator
MTDAKGTPSDDDLVFKALASPVRRQILDLLKESPRTTGEVCAKIEDLDRTTVLQHLRVLETAGLVNGDKVGRQRRLTLAPLPIKRIYDRWIGDYARAAVDLLESLGQ
>NZ_CP019400.1|WP_148279583.1|1802173_1804753_+|glycoside-hydrolase-family-65-protein
MGAGRRGPAPEGGTVDTLDPDADPLDRMRYPVDPWELRETEPPVADARTAETLFAVGNGYLGIRGTSPEGHDATSPGSYVNGFHETYPIHHAEEAYGFARVGQEMIPVPDATVMRLYVGDEPLHLPVADLEAYERRLDLRSGILTRTVVWRTPSKVRVRVVSRRMVSFTRPHLAVMELEVTPLDGDLGLTVVSTVVNRIDAQTALAEDEAGDASLATPLQAELESHPAGPVPDPRKSSKLGAHVLVSTHLGSEGTCTSLGYRAAASGMTLAVGVDHDVTADGPISQYHEESPDAATREFRTRARSGSTLRVVKYAAYHTSRSSASSELAQRCRRTIHDARDVGVDGLVAEQRAWCEGFWARSDVEIAGRPELQQAVRFNIFHVAQAAMCSAGHGIPAKGLTGNGYSGHYFWDGEVYVLPFFSYTTPEVSRSALRFRCTMLPAARRRAHEINMSGALFPWRTINGHEASANYAQGTAQYHIDADIAYALMLYVRTTGDRDFLTRDAIDMLVETARMWADLGFFRTDGQDAFHIHGVTGPDEYTTVVDDNLYTNIMARGNLRDAVAAVRGLRRDRPEQYARMVKRVVLKPDEVALWEHAADAMAIPYDEQLQVHPQDDRFLTKEVWDLPHTSASDFPLLLHYHPLVIYRFQVIKQTDVVLAEFLHSGEFTAEEKARDFHYYEPLTTGDSSLSAVAQAIMAAEIGHDAEAVGHFRELLFVDLADTHHNTDDGIHIASAGGVWSALVYGFGGLRDDPAGGGVRLEPRLPAAWEGLTFRITVQGTRVRVELTHGRIALSVEEGPGTRIEVCGTSYDVSPDSPVVISPQPRERLGEMPTLDDIVGQVRADGTVITPRLPSRSAHH
>NZ_CP019400.1|WP_028700678.1|1800997_1801897_-|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB
MLHARTPLSITKRLAAVTTGLALLAGMTACSGDGKIPEAAGASGGGLTVEKAKQQGTLNIAIGNEPPYTKIAGDGSVTGAEPDVVRAVAKRMGIKNVKGTVTPYDSMIPGLKAGRWDTVAAGLFMKQSRCSQVIYTSPVIVSTESFAVPTGNPKKLTTIADVTKDPKLKVAVLKGGFEEGILDGIKLAGGQKVVVSDAQTGVEALKSNRADAFLLPTLSLTDLKKTTGGFDVTKAISDAPVTGSGAAFATTDKAFADAYNAELEKFKKTSEFDSIMSKWGFDADAARKATVTELCKSKG
>NZ_CP019400.1|WP_015071791.1|1800185_1800989_-|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC
MDALLNFRPLLQSGFVTTLIVTVLGALVALIIAFLVGVARYSKNRILSIPAGIFIEVFRGTSLIVQMFWLFYVLPFFGIDLPPMVTAVIALGFNEGAYAAEIVRSALAAVPKGQNEASIALSLSPRRTLWRIKMPQAIAIMLPSLGNVLVDLFKNTSLVSLVTVVELTFAAQQIRTSTGQTLAVYGFLLVVYFVVSLLLGRLVALAERVVSRRFGTGGPGRRSTGRRTAAAAGPAGVSPVSVPAQVSPMSVPAQVSPVSVPARGGVS
>NZ_CP019400.1|WP_028700684.1|1799532_1800189_-|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD
MMWDPDFAAFVFPSLLRGLGVTIEITLIGSAIALVLGLIVAILRNLRIPVLQQVLWFYVEFIRGTPVLVQAYFAFFVMPKLGVSIDPLQTGILVMGINYSAYMAEVYRAGIESIPKGQWEAVRALSLPGSRAWRRIIIPQAVPPIVPALGNYVIQMFKDSAILSAITVTEMMSRALSAGSSYYRYIEPLTIAGLLFLVVSYLSSILVRRLEKRLVINQ
>NZ_CP019400.1|WP_028700679.1|1798736_1799483_-|amino-acid-ABC-transporter-ATP-binding-protein
MIEFRAVHKAWGANTVLDGLDFKVSHGEKVTIIGPSGSGKTTILRILMTLETPDSGAVLVDGQTLWPVQGSRRGGGRAQDAIRREIGMVFQHFNLFPHLSVVDNIIEAPINVLGLPKDQARAEAADLLERVGLTDHADHKPHQLSGGQQQRAAIARALAMRPRLLLFDEPTSALDPEMVGGVLDVIREVADSHAITMLLVTHEMRFASEISDRVVMFDSGTVVEQGSPDQVFGNPTNERTRRFLSALS
>NZ_CP019400.1|WP_081583500.1|1811035_1811959_-|restriction-endonuclease
MAPVLRVLSDGEIHVLKDIRDAAAEVLNLTAEARAETIPSGQLRYQNRCTWAVSYLKHAAAIESVARGRYRITEEGRGLLVRHPQRIVEADLEEIAGYDPKDSWNSRTAKRALPDGSPGLADDVCPAPTSGTLDELSPTEQVEQAVDQLKAEVAEELLTRLRGNDPDFFERAVVEVLLGMGYGGADKRGKVIGGTGDGGVDGVIDQDALGLDQIYVQAKRYAEGNNVGRQTLQAFVGALQWKNVTRGVFITSSDFTREALDFARTVSTRIILINGARLAELMIRYHVGVQVKETYWIPAIDEDFFVD
>NZ_CP019400.1|WP_154662034.1|1811985_1812144_-|hypothetical-protein
MITGDLRNRIDSVRDAFWFGGILNPLEVILEGQRADGEFVTSLQSRAFTGEL
>NZ_CP019400.1|WP_081685354.1|1812287_1813040_+|sulfite-exporter-TauE/SafE-family-protein
MVHVSIGSLVLLLVAGAAAGLVGYISGLASLVSYPALLAVGLNPLLANTTNTLAQVGAGMGATLRAGRQVWAGGRRRTLQQLAIAAIAGAAGGALLVATGESSFGKVAPWLILFASLMMLASPHLWRLRGESGHWAGYLVALVPVCLYGGYFGAGAGVVFLAAVLMLTTQEYRQSVLMKSVLLAVSNLTASIIFICFTTVDWLVVAVMFVGQLIGGSLGPAVQRHVPNSVSRWVIAVGGVVMACWLWMRG
>NZ_CP019400.1|WP_076692575.1|1813748_1815443_+|HNH-endonuclease
MRRDFWELSGVIEQALDAIDHSGDARMPAVKKVAAMTKARALADRMAALAAVYTDLVARSGATEATAGSPLSDYLAATEGRTSSEANGLVHQASRIGADPAVRDAALAGTVSPGKAAAIGRVLRELPRHDMTPDQRQAAADVLLGQAAGGATTRQIAGSTDRILEQVAPNLAPTPEGRAAEAERQRRRAIRERELTFTDTGKGSVRIFGQVPQMEGDLLRSVVGACVERGRGDERRELEALKIQRASGDLSAGEYLAARTALQEREHRTTAQRQADALTDMIAALQDQGKIPAAGGETPRVVVTLDYMKLLQLAVGAAATGTRPDGTMLDKVLVARLQAALTGTSETGADVPASLVRQACCDAGLLPVVLGDASEILDVGREHRLVTPPIRKALALRDGGCIVPGCTVPASACQAHHVVPWWAGGVTALGNLVLVCRHHHGLIEPHRYNPGSDQWRIDFDQTGTPHVHPPRRMRGDLPADHPDARQNSALSPRPEGIEPVDAATNAGLWQDSAHSPAAGVLENAGPVGSAIPGLVELEPGAEDDREYSVHPPGERGPTQDALIA
>NZ_CP019400.1|WP_148279585.1|1815895_1817419_+|oxidoreductase
MNPTTTLATPRRAAPPTSGDIRRQGAPQSSTGRPPARRRLSRQHWQYAATAVIWLTSLFVVAIWVKGGGIEDAVSLGSNLFMSIGRLSGLVSANLLLLQTILLAQIPVFERGFGRAGITRMHRLTGIWSFSLMVAHIVLITMAYSLQGRMGLLSQFWDFTLHYPDMIFADIAVLLIILVMVTSARRARRRLRYESWHLLHLWAYLGVALAIPHMLSTGGDFLTSPLATAYWWTLWGVAAASIVIFRVGMPLMRSLRHGVRVSRVIPDGSRGVTVQMTGRDLDRLGAHAGQFFTWRFLDGHGWTRGHPFSLSAAPTATTLQISARVVGDGTRRLARLRPGTRVLLEGPFGHMTGQERGEGGLLMLAAGAGVAPMVSILEEEAFAPGQAVLVTRDHDAAELMRSEAIRRLVREKGLVHRPMDGPRARRGASWLPAGHAGWSGARLLQRLAPRSGRIGIDRCEVYVCGPDPWMDAVLRDLARAGFSADRIHSESFNPVPEPSPAPERQNH
>NZ_CP019400.1|WP_028700669.1|1817421_1817943_+|FMN-binding-protein
MKKAFTATMGAVSAVVLAGSYYASLRGAEPSATYVPQTTTGSATSGATSTSGATSGTSSSSSGSTSTSSNSTSSKSTAASSLKDGTYTGSSVQNPFGTVQVQVTISGGKITSVKVPQYPTGHHSDEINQQAVPTLVNETISAQSSQVDMVSGATFTSQGYTTSLQNALDQAKA
>NZ_CP019400.1|WP_015071806.1|1817939_1818848_+|FAD:protein-FMN-transferase
MTGATTPLLKTHRLVRTAEIMGTVVSVHVILDRGEDDGNLSESPLPDSAASDSPVPDPAAPDDAVAAIERSFGELREMDRIFSTYRADSDISRIRAGSLTVEEADPLVALVRRACDRAEVVTGGLFSARWRGGFDPTGYVKGWAVERAFNRWLRPLLGLDGVIAVGMNAGGDMQLATRPDADWRWRVGIADPSRPGMLLATTELTDGAVATSGTAERGAHIRDPRSAKPPTTGAAGATVIADRLSDADVWATAAVVAGINDLGWVARARHTSGLVVGYDGRIRRWAAGDEVDAVRKAGSAVS
>NZ_CP019400.1|WP_015071807.1|1818840_1819833_-|HAMP-domain-containing-histidine-kinase
MTLRPRAADDRSIRSSTLRIGLMVGVTSALVIAGGIAILLWRISARSRPEAAEGMRRDHGHDHVVVDVNDVVPWLVVFGIAAVVLLGVIAWYSARRAVAPLAEALRRQRHFVADASHEMRTPLSALVSRTQILERRRARGEPIDDVIARLRGDAEAMSEVLTDLLTAAAADAGSLQEDAPDTPAHPMEALGRAAERMEPLASPHDVRIEVTGGSTASVQLAAPTLERICVALIDNAIDHSPQGGVVAVSCAQKGSTVEIRVGNQGPEISEEDRARAFERFARGAETGRHRGFGLGLALVREVAIRARGSVEIEETSPAGTVFLLRLPAVS
>NZ_CP019400.1|WP_015071808.1|1819829_1820513_-|response-regulator-transcription-factor
MTLPDVLYAEDDDQLAEMTVEVLSEYYDVDHVADGAEALDHALHRSYGVIVLDRRLPGMDGLALVRAIRQARIATPVLLLTALGAVDDRVEGLDAGANDYLVKPFAFEELLARMRALHRGFTAAGRRRRIGEWILTPDTQAIYSPTEARIPLTATETALLDVLAASPEHIFSRQELVGAVHRADQDEDRETVSTASVDTYVHYVRRKTVPEIIETVRGRGYRLGDPR
>NZ_CP019400.1|WP_028700666.1|1820517_1821240_-|VIT-family-protein
MDENVKPHEDEQHATNTGQKLNWLRAGVLGANDGIVSTAGVVIGVAGATPHNVAAIATAGIAALVAGAFSMAGGEYVSVSTQRDTEKALIAKEKWELENMPEEEREELADLYRQRGLSEHLAHQVAEELMAKDALAAHAEIELGIDPDHYTSPWAAAASSFVSFTVGALIPLIMILLPVGEHRIWIAAAAVVLGLFLTGLISATLGGAPRGRAIIRNVLMGSATMVATYLIGLAFGTAVL

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Crispr_ID: NZ_CP019400_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_7

1949807-1949921

Orphan

Consensus_repeat	Method
CTCATCGCCGGGGGTTTGAAGGGGGTTGCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_7

>merge|NZ_CP019400|7|1949807-1949921|CRISPRCasFinder
CTCATCGCCGGGGGTTTGAAGGGGGTTGCCCCCGGCCCAAGCTCCTCCGACAGGCCAGCGACGGTGGCCCGATCTCCGCGGACTCACCGCCGGGGGTTTGAAGGGGGTTGCCCCC

>NZ_CP019400|7|7|1949807-1949921|CRISPRCasFinder
CTCATCGCCGGGGGTTTGAAGGGGGTTGCCCCC	GGCCCAAGCTCCTCCGACAGGCCAGCGACGGTGGCCCGATCTCCGCGGA
CTCACCGCCGGGGGTTTGAAGGGGGTTGCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_081685352.1\|1941444_1942671_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|172015
NZ_CP019400.1\|WP_015071913.1\|1943362_1945027_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_051143589.1\|1955589_1956105_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP019400.1\|WP_015071918.1\|1947545_1947731_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182658
NZ_CP019400.1\|WP_028700612.1\|1959161_1959635_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP019400.1\|WP_015071914.1\|1945046_1945187_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028700611.1\|1959764_1960310_+\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NZ_CP019400.1\|WP_015071926.1\|1956101_1957604_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NZ_CP019400.1\|WP_028700613.1\|1957607_1959074_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP019400.1\|WP_028700615.1\|1952519_1954145_-\|anaerobic-glycerol-3-phosphate-dehydrogenase-subunit-A	unknown	unknown	gnl\|CDD\|274552
NZ_CP019400.1\|WP_028700609.1\|1961925_1964652_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NZ_CP019400.1\|WP_028700616.1\|1951176_1952523_-\|glycerol-3-phosphate-dehydrogenase-subunit-GlpB	unknown	unknown	gnl\|CDD\|235412
NZ_CP019400.1\|WP_015071917.1\|1947269_1947506_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_138575215.1\|1939421_1940522_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP019400.1\|WP_081685353.1\|1940483_1941467_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP019400.1\|WP_076692580.1\|1945738_1947283_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273736
NZ_CP019400.1\|WP_148279643.1\|1947778_1948513_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|188353
NZ_CP019400.1\|WP_028700614.1\|1954497_1955460_-\|D-glycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240626
NZ_CP019400.1\|WP_028700610.1\|1960735_1961929_+\|DNA-repair-exonuclease	unknown	unknown	gnl\|CDD\|277319
NZ_CP019400.1\|WP_015071912.1\|1942667_1943366_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213231

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_081685352.1\|1941444_1942671_+\|DUF2029-domain-containing-protein	gnl\|CDD\|172015	PRK13375, pimE, mannosyltransferase; Provisional.	2.31586e-33
NZ_CP019400.1\|WP_028700612.1\|1959161_1959635_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.87265e-11
NZ_CP019400.1\|WP_051143589.1\|1955589_1956105_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	5.27051e-16
NZ_CP019400.1\|WP_015071918.1\|1947545_1947731_+\|hypothetical-protein	gnl\|CDD\|182658	PRK10699, PRK10699, phosphatidylglycerophosphatase B; Provisional.	0.00362294
NZ_CP019400.1\|WP_028700611.1\|1959764_1960310_+\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	7.45671e-58
NZ_CP019400.1\|WP_015071926.1\|1956101_1957604_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	5.90616e-97
NZ_CP019400.1\|WP_028700613.1\|1957607_1959074_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	1.88479e-150
NZ_CP019400.1\|WP_028700614.1\|1954497_1955460_-\|D-glycerate-dehydrogenase	gnl\|CDD\|240626	cd05301, GDH, D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH). D-glycerate dehydrogenase (GDH, also known as hydroxypyruvate reductase, HPR) catalyzes the reversible reaction of (R)-glycerate + NAD+ to hydroxypyruvate + NADH + H+. In humans, HPR deficiency causes primary hyperoxaluria type 2, characterized by over-excretion of L-glycerate and oxalate in the urine, possibly due to an imbalance in competition with L-lactate dehydrogenase, another formate dehydrogenase (FDH)-like enzyme. GDH, like FDH and other members of the D-specific hydroxyacid dehydrogenase family that also includes L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase, typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form, despite often low sequence identity. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	4.74258e-148
NZ_CP019400.1\|WP_028700609.1\|1961925_1964652_+\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	8.5342e-09
NZ_CP019400.1\|WP_028700616.1\|1951176_1952523_-\|glycerol-3-phosphate-dehydrogenase-subunit-GlpB	gnl\|CDD\|235412	PRK05329, PRK05329, glycerol-3-phosphate dehydrogenase subunit GlpB.	7.00977e-131
NZ_CP019400.1\|WP_138575215.1\|1939421_1940522_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.43224e-21
NZ_CP019400.1\|WP_081685353.1\|1940483_1941467_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.29386e-35
NZ_CP019400.1\|WP_076692580.1\|1945738_1947283_+\|hypothetical-protein	gnl\|CDD\|273736	TIGR01654, unnamed_protein_product, bacteriocin-associated integral membrane (putative immunity) protein. This model represents a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins (TIGR01653). Others may be associated with uncharacterized proteins that may also act as bacteriocins. Although this protein is suggested to be an immunity protein, and the bacteriocin is suggested to be exported by a Sec-dependent process, the role of this protein is unclear. [Cellular processes, Toxin production and resistance].	1.19568e-09
NZ_CP019400.1\|WP_148279643.1\|1947778_1948513_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|188353	TIGR03608, L_ocin_972_ABC, putative bacteriocin export ABC transporter, lactococcin 972 group. A gene pair with a fairly wide distribution consists of a polypeptide related to the lactococcin 972 (see TIGR01653) and multiple-membrane-spanning putative immunity protein (see TIGR01654). This model represents a small clade within the ABC transporters that regularly are found adjacent to these bacteriocin system gene pairs and are likely serve as export proteins. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	4.49853e-81
NZ_CP019400.1\|WP_028700615.1\|1952519_1954145_-\|anaerobic-glycerol-3-phosphate-dehydrogenase-subunit-A	gnl\|CDD\|274552	TIGR03377, glycerol3P_GlpA, glycerol-3-phosphate dehydrogenase, anaerobic, A subunit. Members of this protein family are the A subunit, product of the glpA gene, of a three-subunit, membrane-anchored, FAD-dependent anaerobic glycerol-3-phosphate dehydrogenase. [Energy metabolism, Anaerobic].	0
NZ_CP019400.1\|WP_028700610.1\|1960735_1961929_+\|DNA-repair-exonuclease	gnl\|CDD\|277319	cd00840, MPP_Mre11_N, Mre11 nuclease, N-terminal metallophosphatase domain. Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain (not included in this alignment model). MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.42073e-28
NZ_CP019400.1\|WP_015071912.1\|1942667_1943366_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.07038e-95

>NZ_CP019400.1|WP_148279643.1|1947778_1948513_+|ATP-binding-cassette-domain-containing-protein
MTPLKDAPFTLTATGLTKTFGNRTLWDGFSFTAESGTMTAITGPSGAGKTTLLNCVGLLEGFDAGQITYGPWSFTGGPPHHVGSWERSCLREVLGFLFQNYGLVETWNVRRNLMVPLRNRRGLSSKAREAMITQALERVGLPEAQKTMIYTLSGGQQQRVALARLILKDPSVVLADEPTSALDHANRDLVLGVLQELADTGALVLIATHSDHVADRCTGRVELGPAHQEQRHEADPRPAVTSTS
>NZ_CP019400.1|WP_015071918.1|1947545_1947731_+|hypothetical-protein
MLAGDLGLAVLTATATRMIGGMHLPRDLAAAAILVAAQVSVAAVFVRVYETRSRADFIKRP
>NZ_CP019400.1|WP_015071917.1|1947269_1947506_+|hypothetical-protein
MLFFDADDLNQRLTSAGIRGHFQGIDNAADAVTETLAASRLEQRMDVFGISLGMVVLVLATMVSAAVYCDRHRRTSFV
>NZ_CP019400.1|WP_076692580.1|1945738_1947283_+|hypothetical-protein
MFITVDEAQPMGTRSAFTVDRVNAPSKEAAIQAISASALQSHTNIFKVQAGDTDSFQSRTLFAFIGNRDAFARSGGYSYPTFSAQSQRTTITPADRITTQDLRGVYATSADHSQVVSILADLRKAGISADDSTATGFEIFVYALGPANLGAAFVIVYVALALALAYSGTTNRKAHAIKSLHGYGRAPILGAELGSAGATFGLGLAALLLIGTPVLWAVTRFHQVWRFAGFLGTGLGVLALLTAVLVTVLGGVATLRHRIPEVLKGERAPLADGVLDAATQVIVLAVVLASTSGAMWRIEAVSRTSRELSRWSQMPPAYALRLSTASTHDDDLRDAPALTSIISRMDRQGTVLMTGYKGGELANGGDGTTPPGPEGANSMIVNPKYLGVQPVLGTDGHRIRNIAIARNGFTLLVPASYHGDVGALLATYTKYFKEYSCLLGAPKSTPPCAPPRPGDPHCRRTTTVHLQRHRSLSRGGPGENITDRSRPSGRLTIIWAHRPHGIPLLHFPELCAVL
>NZ_CP019400.1|WP_015071914.1|1945046_1945187_-|hypothetical-protein
MTWSASEGDADAPNAALVDEISGWPDEPGFGADDVLEALDVGRQER
>NZ_CP019400.1|WP_015071913.1|1943362_1945027_+|hypothetical-protein
MSRGITLWARHHLVVPCITVAVLASAAVRGLVLLIAADGGTVEVAPLWVATVAAVPLLFMFTTETDADRAAPRSLAARRWTLLGIAVLVSGVIALATFPTTSGEWGFLATWRDAVALLGLGLLSLTVLPPAAIWVTPLVAAMASMTFSWPLHPTLPLGLWGALHAPADAFLDPGVPNLSIPLCLLIGVAGIVTFARGLRWAPRTFTSKAQQPRKNAVTHRRSGTRGLRRASLTVPMACLVAVVSAWPWMTSLSWWGGSPRLLLGDEVPASVFIAVACAVLLGVVSGQYRWRSGVAVWQQLSTRPAWTLLARAAGRAAATAVAAVGAPALAMALVTAGDLARHGVGADVVATEFLAGWPPTLLVLAEVAIGAALGACAGWWSGRIWMAPACLILGLAVMIAVPRPPSQDVDRKWAERYGYTACQTVPGQDVRVCAPAPDKGYLPAAAASLSQIYSQSPHPEALPRLVRLTTTGTMGGNIHPKGLENPPDVGAAPGRGITPPTVLGAPAGDSLTYSTHAWCAGTDLTDLQKLFGVEDYAQTPTMDRTLAALKTCRG
>NZ_CP019400.1|WP_015071912.1|1942667_1943366_+|ATP-binding-cassette-domain-containing-protein
MTLTVDELTVQYRKRTAVDAVSWRLDEGFHALLGPNGAGKSSLLRAIATLQPASGTVELDGHTGTAIREQLGYCPQENLGRSRFTVREHLAYMCWLHRIPDPKTPAEVDRVLDLVSLTDRADDRISALSGGMRRRVGIGSALVGSPSLVILDEPSAGLDVAQRESLSVVLRRVAANAITIVSTHIVEDVLDHADTLTVMDQSRFVFSGAFDDFAGSRDLEAVRSRYLEMVTP
>NZ_CP019400.1|WP_081685352.1|1941444_1942671_+|DUF2029-domain-containing-protein
MLFLLIHILSRQLVPIDFNVYWQGGSDVLRRTGALYAPRPALPFTYPPFAGLVFAPGALLRPTSSAAMMEFLSCVATVYLTSQIIDLAPHRFVNFRNSHPWCFLSLGATLMCCLNPVWETLAKGQINLILAAVCLFALTTDRRFTGGVLAGLCGGIKLTPLALGLVALRQRDWRFILGMGCGFTGSITVGVLLLPVESGLYWGRLAWDPGRVGDVGFVANSSLNAVIRRAAKLVVPTPGGQPAIVSIAWAALVVVTVIAGFLALPGDRAHPTASLGVGTAVMLLISPVSWNHHWVWMPFIAMWASTVIRSRAIRWLLGIVALPIAVLGPQLVCRALHATARDPRSVVAWWASSAIPLATFGILITAGVRAVRESMLQSSPPIPGPQPEPPGRLAPAGLVSTHVKEGTS
>NZ_CP019400.1|WP_081685353.1|1940483_1941467_-|response-regulator-transcription-factor
MWIKRNSMPPTATTLAESALLLLDVNRVTPSSWNSRPRSADVVKVACPGDFASFGLENRSAGSGATLWRGVCAQQEAQANSARSGTKLPDRAIVDISYPGPSGRAVPGGYDPAMSAGGIRVGICDDSQVVRRQMGTYLSAAPDIVVCGMYGSGPDAIAGVSRDDIEVMLLDVRMPGMTGPAVASELAASGSGCKILYVTSYPDEVPVRGALRQTVLGALTKDVSPENLVAAVRLVASGVSLLAPEFIRESAAGGEGLMDWSADPREREVFRLVQTGATNARIAEELNMSTSWAKQTISALCRRFGVKGRAALAAYSGGAAFDHGVRN
>NZ_CP019400.1|WP_138575215.1|1939421_1940522_+|histidine-kinase
MALRRGLLHRTLSSGAMEVTLAIVLLAIDALPFHPGYDATLALILGIIACGGAALTAWHPRIGAVIACLGFGGLALLPDNMVGPTLYALMIVILSCAWHEEFWTAVATSAWGYGVSLWLSFRNTTTMREDLQAIVVWLGVYALPWVVGLALRNTQFVERRRIAARAEAQRREIADELHDNVTHELALITMTAEATRIDPTIDKDDALVDIAAMSRRSSAYVRHMVSLMRAGIASPPLSFSTEIRNGLARLADAGFSVEPEIGDGVDSISPAMSSALGHIAHEAFNNILRHGSPDGLCRVTARADSSGLRATFTNATTTAYHGDDLGITGMRDRAEGLGGTLDTRLSHGRWTVRVSIPDAMVEGSAS
>NZ_CP019400.1|WP_028700616.1|1951176_1952523_-|glycerol-3-phosphate-dehydrogenase-subunit-GlpB
MTTTAVSTTAARIGAQPHVVVIGAGIAGLTAALRLRRAGARVTQVTKGLGGIQLSQGTIDILGYTPDRVSRPLDAIDDYAAAHPAHPYAKIGSDAVRQGVAFLRDVAGEEFLVGDGEENVNLPTAVGAVRPTALIPPSMTAGVLHDGLKVVIIGTAQLKDFHPMLVAQNLERTVLPDGGRVQARAVMTDFEPRPNEFDASGLTFARALDDPKTRRAFAEGLKGFVNEGEAVGLPAVLGLDDHQAAIAEISSIIGAPVFEISSLPPCVPGMRLNEKLVTTVKTERVEFILGSKVIGRTAADGKITSVTVGVAGHKREIACDAVILAAGGFESGALRLDSHGTVHDTVLDLPVKLPEGIDADTLTHEDYWGKPQPLFEVGVDVDSSMKVIKDGVPVFDNVYAAGGVLAGATRWQDKTGEGIALGSAVKAADAVLAGLPVAAPAAQTAERN
>NZ_CP019400.1|WP_028700615.1|1952519_1954145_-|anaerobic-glycerol-3-phosphate-dehydrogenase-subunit-A
MRTMDADVVVVGGGATGAGVVRDVAMRGYSAVLLDKADLAQGTTGRYHGLLHSGGRYVVSDQGSATECAEENAIVTRIHGEAVERTGGLFVVTPDDPMEFSDQWTEGATKSKVPWEEISVAEALRREPRLNPGIKRAFAVQDGTVDGWQMVWGAVHSAIDHGAKVLTYTPVTEIIREGDQVTAVVAHDLRKDEDIRISTRFVINTAGPWAGRIADLVGCHDVDVVPGRGIMIAMNHRLVNTVVNRCIYPADGDILVPVHTVSIIGTTDVKADDPQKLPIPRNEVQQMFDSGEALIPGFRDSRAVHAWAGARPLFKDKRVAATDTRHMSRGMSILDHGTRDGVKGIVSIIGGKLTTYRLMAKNVTDVMCEQLGDDRPCTTDKEAVPGASEGKNYLITHRLGVNEKARSSHMEPKAKAPVKKNAIDDQVICECELMSRKMLTDLLAEQPDATFDDLRRQLRLGMGPCQGGFCSMRATGVALEEGNIDVERATGLLRLFLKNRWIGLWPILFGEQVRQTALDDWIFQGTFDVEHLPVPESEVEL
>NZ_CP019400.1|WP_028700614.1|1954497_1955460_-|D-glycerate-dehydrogenase
MARIIVTAPQMPDALDLLRDHDVMGGDHFMTREELEEAIVDADAVLSSLSDPLDADMLARAPKLKVIGQCAAGFNNVDIEAAGKQGIVVTTTPGVLHEATADLAFGLMLMATRRLGEAERLVRAGTPWRYDHTFMLGAGLQGATLGIIGLGQIGEAMARRGAAFGMDVVYTARHDHDTSAVDATNPATATTRRVDLDELLRISDVVSLHCPLTPETTHIIDSAALEKMKPTAFVINTARGACIDENALVAALRAGKIAGAGLDVYEHEPSITPGLLEMENVVLLPHIGSAARPTRGVMSALSVRNILAVLDGKPAETPVN
>NZ_CP019400.1|WP_051143589.1|1955589_1956105_+|winged-helix-turn-helix-transcriptional-regulator
MQSIDNPGTPRAAETGDLADEAVEATRVLVDIAARSLLGVGDDITLPQYRVLVLVDGGETMRGVDLSRALGIHASTSSRLVNRLVVKGLMDRTPDAQDRRSNSLAITAAGHRLVSRVNYRRRREMRGLLEHLGADEISAVLDGLRLFNAAAVASGHGTPAPPEKSDDRGRR
>NZ_CP019400.1|WP_015071926.1|1956101_1957604_+|chloride-channel-protein
MSHAVPGAPEPHTPASAGTGTTGTGRSGDRAPQEWKNLLRRFRSALVPRRPKAFRDSLNRWLLMGVVIGVVSGLGAILFYFCLHTGTRWLLGYLGGYTPPSTAGEGDGTAGSGFTRPWAIPLVVTGGALVSGLLVYFVAPAAKGHGTDNAIRAAHHDPTSLRGKVAAVKIVASSILIGSGGSGGREGPTAQISATVISSLCRRLRIKTPDARIAVIAATASGIGAIFRAPLGGALLGAELLYKDDLEADAMMPSLISSIVAYVVFGSVYGFDPIFGTLSGEVFNQPLQIIWFVVIGLAAGAMGRLYCVTFYRGCDFFDRLPLPGWLTPAIGGLCVGLLGLAIPAALGTGYGSIAQQMIPETLTAMPMLMVLAIPFAKIAATTLSIGSGGSGGVFGPGMVIGGATGAAVWRLLEGLPGIPASPTSFIVVGMIACFGAAAHAPVGMMLMVGEMTGNLSLLAPGMIAVAVASRVVGPVSIYRSQLTDRLEGRKVHSQVPAHTQ
>NZ_CP019400.1|WP_028700613.1|1957607_1959074_-|amino-acid-permease
MSSPSKTSASPQATQGGSAPAPQMKGRHLVMMSLGSAIGTGLFLGSGKGIAAAGPSVLVAYVVAGLVVIAIMRMLGEMVAAHPDSGAFSVYTARAMGPAAGFAMGWVWWVELAVVVAAEGTAAAQIFLAVWPIAPDWLLTLIFMVALTAINLFGVDKFGEFEFWFALIKVAAVVAFLVIGVLLLCGVFPAPAPGLSNFLHHGGFMPNGWGGVATGLLIVIFAFGGIEIVAVAAAETENPRKHVGKAINTIIWRILVFYMGSVAIMVFALPWDDPKLASSPFVAVLDLAKIPGADAVLTLIIVLAVLSSLNANLYGDSRMLGSLAERGLAPKAMTGKNRRNVPVAAVLSSVAFGYVCVVLTYIWGAKVLDVLLNVVGSVIIVTYLFTIASQIILRRRAEKTGEELPFRMWGYPYLSWLTLAVLIGIIGLGMTDAGVRGQILATFGLTVVLFVIGIVRTRRLGQDPFKPVVTPGDRLVDADPAAEPAGTD
>NZ_CP019400.1|WP_028700612.1|1959161_1959635_-|MarR-family-transcriptional-regulator
MAEDTPWLDDHQQRVWRLWLDVTNGLPALLNKQLARDTDLSLQDFEVLVSLSEAPDQSMRVVAMADVMHWERSRLSHQLTRMEKRGLVRRESCCTDGRGQLVRLSDAGWDAVVAAAPGHADTVRRVIFGGLNMDHLDELEKILNHIRETMNEERQEL
>NZ_CP019400.1|WP_028700611.1|1959764_1960310_+|YceI-family-protein
MTSLAELNGNYTLDPTHTRLGFVTRHAMVSKVRGSFTELEGTASGDGADPSSAKVSVTVKTDSFTTGVADRDGHIKSGDFLEVDKYPEITFVSTGAAIKGEDLELTGDLTIKGVTKSITIPFEFNGEAKDPFGNTRIGFEGKTKISRKDFGITWNAALETGGVLVSDEVTLELEVEGVKQA
>NZ_CP019400.1|WP_028700610.1|1960735_1961929_+|DNA-repair-exonuclease
MVRFLHTSDWQLGMTRHYLAPRPGAEDDAQARFTADRIEAVRRIGRIAREEHCSFVVVAGDVFETQNVSRRVVALACEAMASIGLPVFLLPGNHDSLEPGCIWDQDLFTDRCPSNVTVLRDTEPVDVADGVQVVGAPLTSRHPSSDPIAPAIADIQPDGTTRILVGHGQLPGLSGQDSEEAEIDATAIQDALNSGAISYAALGDRHIRWPEDPHAAIRYCGAHETTRFTDPARGSVDVVEISGGRVTATPHEVGRWLHVRVSREMATDEDIDAMAAELSGFDDPTRTIVRYDLHGHLSVAQNARLEALLSDRQEVFASLEPSADRHDLVVTPDDGDLDGMDLPGWAASAAAELSEAAASSPTAIDALGLLRRLAMASPPGRAETPAVGEAHSGEAHR
>NZ_CP019400.1|WP_028700609.1|1961925_1964652_+|AAA-family-ATPase
MRLHRIHVENFKSVEDRTLELPDTGLVIAEGLNEVGKTSMVEALDMLLDPKLKATSKSAKVKTAQPYGTDLPVIVEAELTVGGVRLVHSKRFLAQPAARLEFLSGPRAGDVLTDERATDTMAEIWAGTDQTLWRALRHMQSDSLEALSLKSSTALTSALDRASRATDDESGHRADDTTLLEAAEQEFAKYWTGTGKPGKPLKDATSALEQSEAELDAARRELDEVDTVVAELQTAEEDLRAQRRDVGRLETESAADATALKALEGLEQQVAEARRAERDARQRLDTAASARQARRQAVEEVDVAGQQVSEATAAVEKAHDAAGDVEEEYREADERWDACEKARLDARRAWQEARATVSGLRDRDRLARLDAVIGRLSGLRNELREAESRLEGNFASAKGLKAAEKASARLAAARTKLEVASPRMRIERLRDDAPALAVDGRPIEDEEDGDAVDRVVDRPAVVEVADAWRITVTPASDVDKLAHDVERAERELTEALEPMGADTLEAARELLAARGRDENLAAGLRERLERELTDVDEWEDDSQERSVAGLTELRDRLAARVGEAAEDDADADGTGAAAGSGDVGDAGLTVGQAEEAATRCEAAHDQAELAEKAARAAREAVGERRSAAREADSAAASTLTAARGQAERLAARLEEARGIATDEDLDARVEAEDTAHQEAEGEFEKVSGELAEHSPDEVREAARASRARFEKASERLGRTGTRWAGLDGQLRGMDRSGRQDRFDDMEGRVHRLRIEVTALTKRADAARLLRDTLVRHRDEERRRYLEPFTRQIETLGRGVFGADLAVRVDDSLTVTQRRLGGKWLAWDQLSTGAKEQLGLVVRLATARLVSPEDGVPVILDDALVYSDRVRCGRVLKEVSSGSQANQVVVFTSAPERYDAVDAVHVDFR

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Crispr_ID: NZ_CP019400_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_8

2399345-2399444

Orphan

Consensus_repeat	Method
CCCCCTGCGCTCGCGCAGGCGCTCGCTGACCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_8

>merge|NZ_CP019400|8|2399345-2399444|CRISPRCasFinder
CCCCCTGCGCTCGCGCAGGCGCTCGCTGACCCCTCGAGCGGGTTGGGTCTGCGTCCGGGTTCGGCGTCCCCCTGCGCTCGCGCAGGCGCTCGCTGACCCC

>NZ_CP019400|8|8|2399345-2399444|CRISPRCasFinder
CCCCCTGCGCTCGCGCAGGCGCTCGCTGACCCC	TCGAGCGGGTTGGGTCTGCGTCCGGGTTCGGCGT
CCCCCTGCGCTCGCGCAGGCGCTCGCTGACCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015068998.1\|2404958_2405588_-\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP019400.1\|WP_015068994.1\|2398193_2399324_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP019400.1\|WP_015068996.1\|2402669_2403629_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP019400.1\|WP_081685365.1\|2401260_2402976_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP019400.1\|WP_028700778.1\|2394641_2396105_+\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NZ_CP019400.1\|WP_148279460.1\|2410366_2412391_-\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_CP019400.1\|WP_036936932.1\|2396266_2396899_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NZ_CP019400.1\|WP_015068995.1\|2399482_2401201_-\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP019400.1\|WP_015069001.1\|2409536_2409911_-\|DUF488-family-protein	unknown	unknown	gnl\|CDD\|225730
NZ_CP019400.1\|WP_015068986.1\|2389421_2390543_+\|sodium-ion-translocating-decarboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|377182
NZ_CP019400.1\|WP_015069002.1\|2409933_2410422_-\|DUF309-domain-containing-protein	unknown	unknown	gnl\|CDD\|377120
NZ_CP019400.1\|WP_028700776.1\|2388936_2389419_+\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	unknown	unknown	gnl\|CDD\|236449
NZ_CP019400.1\|WP_081583297.1\|2405584_2408377_-\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|259871
NZ_CP019400.1\|WP_076692596.1\|2397329_2398031_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015069004.1\|2412407_2412647_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NZ_CP019400.1\|WP_028700780.1\|2396895_2397330_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028700782.1\|2408330_2409401_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_051281762.1\|2393690_2394485_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP019400.1\|WP_051281742.1\|2392341_2393694_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP019400.1\|WP_028700777.1\|2390796_2392218_+\|phosphoglucomutase/phosphomannomutase-family-protein	unknown	unknown	gnl\|CDD\|100093

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015068998.1\|2404958_2405588_-\|ArsR-family-transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	2.69226e-19
NZ_CP019400.1\|WP_051281742.1\|2392341_2393694_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.28692e-06
NZ_CP019400.1\|WP_081685365.1\|2401260_2402976_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.1313e-88
NZ_CP019400.1\|WP_015068996.1\|2402669_2403629_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.79795e-72
NZ_CP019400.1\|WP_028700778.1\|2394641_2396105_+\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NZ_CP019400.1\|WP_036936932.1\|2396266_2396899_-\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	3.60252e-20
NZ_CP019400.1\|WP_015068995.1\|2399482_2401201_-\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.51484e-143
NZ_CP019400.1\|WP_015069001.1\|2409536_2409911_-\|DUF488-family-protein	gnl\|CDD\|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	4.25455e-46
NZ_CP019400.1\|WP_015068986.1\|2389421_2390543_+\|sodium-ion-translocating-decarboxylase-subunit-beta	gnl\|CDD\|377182	pfam03977, OAD_beta, Na+-transporting oxaloacetate decarboxylase beta subunit. Members of this family are integral membrane proteins. The decarboxylation reactions they catalyze are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.	0
NZ_CP019400.1\|WP_015069002.1\|2409933_2410422_-\|DUF309-domain-containing-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	1.03966e-24
NZ_CP019400.1\|WP_028700776.1\|2388936_2389419_+\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	gnl\|CDD\|236449	PRK09282, PRK09282, pyruvate carboxylase subunit B; Validated.	1.32121e-28
NZ_CP019400.1\|WP_081583297.1\|2405584_2408377_-\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|259871	cd04208, CuRO_2_CuNIR, Cupredoxin domain 2 of Copper-containing nitrite reductase. Copper-containing nitrite reductase (CuNIR), which catalyzes the reduction of NO2- to NO, is the key enzyme in the denitrification process in denitrifying bacteria. CuNIR contains at least one type 1 copper center and a type 2 copper center in the protein. The type 2 copper center of a copper nitrite reductase is the active site of the enzyme. A histidine, bound to the Type 2 Cu center, is responsible for binding and reducing nitrite. A Cys-His bridge plays an important role in facilitating rapid electron transfer from the type 1 center to the type 2 center. A reduced type I blue copper protein (pseudoazurin) was found to be a specific electron transfer donor for the copper-containing NIR in bacteria Alcaligenes faecalis.	3.69553e-54
NZ_CP019400.1\|WP_028700777.1\|2390796_2392218_+\|phosphoglucomutase/phosphomannomutase-family-protein	gnl\|CDD\|100093	cd05800, PGM_like2, This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.	0
NZ_CP019400.1\|WP_015069004.1\|2412407_2412647_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	1.47766e-14
NZ_CP019400.1\|WP_148279460.1\|2410366_2412391_-\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP019400.1\|WP_051281762.1\|2393690_2394485_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.96029e-91
NZ_CP019400.1\|WP_015068994.1\|2398193_2399324_+\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	6.30011e-141

>NZ_CP019400.1|WP_015068994.1|2398193_2399324_+|6-phosphofructokinase
MAKKKKVGILTAGGDCPGLNAAIRGFGKAAIRQHGMELIGFQDGVRGLAENRYIPLDGRALSGILTIGGTILGTSRDKVNRMVVDGETRDMIPTIKENYEKLGLDALVTLGGGGTARNANKLSKAGLNVLHLPKTIDNDIVGTDDSFGFSTALEIATDAIDRLHSTAHSHHRIILAEIMGHRAGWLALGSGIAGGADIILLPEVPYHLDSIVKAVEQRRKDGLNFSVIAVAEGARDETDALAMSGAQALVDESRTPDTKAAAKKAKKDLERSMRDNTIKLATQLEDATGLESRVTILGYVQRGGTPCAQDRLLATRLGTKGAQLVDDGQFGIMVTAQGTGTGTIPLKDVGGKVKYVPLDHPWVEAARSVGTSLGDD
>NZ_CP019400.1|WP_076692596.1|2397329_2398031_-|hypothetical-protein
MGAMHGWALTVDQRRSRMSEDLVPALQRVLAELPVLDDTGATPARPPRWDLPAERTAGDEVQAFTTDPGTLVAAVWAVCGQKLWWCGVGLGAVRTPLPGSTREAAGSAYIAARVAVEEAKKAINGVSVEVAEAPAPRLVQVLDVLAEVVGSLTSAELDVCDLYDRGMARPAIAGRLGISAPAVSKRLTTRRWEFLRRTRALAVDLAAEALSERTAQDQALSKRTVSKSTGRGD
>NZ_CP019400.1|WP_028700780.1|2396895_2397330_-|hypothetical-protein
MLIDVLVTLVLAVIAVPGGAPVVRAVFWAATPSAERRTSLWTAMWSRQTDDGVLRGGRWIGYLERLGIAATLLAGQPGGVAVIAGVKTLARYAELHSTPAPGTDAGQARRQSQAAIEQFIIGTLTSFIWAGMLALLTRRLWWVW
>NZ_CP019400.1|WP_036936932.1|2396266_2396899_-|hypothetical-protein
MSPDDSDLIRRWERLGVESTKAAGLGSRLIARWGRPHRFYHGLEHLRGALDALERFGGGRLEAVAVFFHDSVWTLPSDPDHGADEARSADLARTWLVGALPAEQIEEVARLVMVTADHLPEAADPPGCRVSDADLAVLAAPWPRYAESVAGLRVEAGLAGPGTAEDWSALRRGQIAELLGRPWLYRVAPPAWETAARANLTRERDLLTIL
>NZ_CP019400.1|WP_028700778.1|2394641_2396105_+|NAD-dependent-succinate-semialdehyde-dehydrogenase
MTTTDRSLPTDLPNQLLIGGRWVDADESRTFDVIDPATEDVLISIADAGEDQGLDALTAAVDAQDAWAATAPRERAEILRRGWEIVTERKDDFARLMTLEMGKPLAEAYGEVTYGAEFLRWFSEEAVRIRGDYGILPEGKVRQLVMKRPVGPCLFITPWNFPLAMATRKSGPALAAGCTVIIRPASSTPLTTLLFAKAMQDAGLPDGVLNVITGLDHGVTDKILADRRLRKLSFTGSTPVGRHLLSQASEHVLRTSMELGGNAPFIVFEDADVDAAVEGAKGAKMRNMGEACISANRFIVHESVAEEFTEKFTAYMSGLVVGDGMEKGTDVGPIIGEGDRQKINALVESARNAGGTVLTGGEIPSGRGYFYPPTVITGVPADAEVMTTEIFGPVAPITTFSTEEEALRIANSVPVGLAGYVYTRDVDRIQRMGAKLETGMVGANIGVFSNAAAPFGGVKESGLGREGSYQGIEEFLETIYVALPNPA
>NZ_CP019400.1|WP_051281762.1|2393690_2394485_-|ABC-transporter-ATP-binding-protein
MLSRTVHQTSPAQAGDPLAGHPPVIIADSLVKTYGPTRALDGVGTIIGAGESVAVMGPSGSGKTTLLHCLSGILAADSGSVELLTPEGGIRVDGLDAAGRARLRRERLGFVFQQGMLVPELTAVENVALPLMLNGVDRTTAEARASQWLAALGLPGLEGRRIGQLSGGQAQRVAIARAQVTDPAIVFADEPTGALDSRTAEEVMGALLESTTGRGRTLVVVTHDLNVARTCGRILTLADGRIVADQRRPGTAAHTENSRQEALR
>NZ_CP019400.1|WP_051281742.1|2392341_2393694_-|FtsX-like-permease-family-protein
MNATWPILRMLARPTLADRRSWALPVTAFAVIATIILDVTAGAAMFWRIPGDMATTYRGLAGVAVVLLVLPLVTLASSATRLSARRRDDRLSALRLLGATSGTLRLLTLAESGAYALAGSLIGVVGYAITLPLLAMLPFNGGPIGVGSLLLGPLPLLGVIAALVVLALASSAVSLRRVEISPLGVAMRSSAQGVSRMRIIAGGALLAVAAGAAAIAPRLGMAAAPIIVIMVVLLAIGAGLTVINIVGPKLLAVHFRSRLRRARTAPALVAARMVLESPKAAWRQVSALGSVCFVGVAGGAGVALLSRTSGSGADRAEAILIGDIRTGIILTIVFAFATVACSVGINQTSAVLDRRDIEVGLDLVGMTAAEQEEVRRRAVLGPLWFVMAVSVLSSVAVLLPLVGAALVMSPVTMAVTAGVIAAGAGMVALGLRATHGTLAGVLEEGLARVE
>NZ_CP019400.1|WP_028700777.1|2390796_2392218_+|phosphoglucomutase/phosphomannomutase-family-protein
MADEIEFGTGGWRAVIADTFTKANVRRVAQGLADRIHDEDVADRPVVIGYDQRFLSPEFAWWAAEVLAGNGIHVRVIDRPAPTPMIMWTVRDKGCAYGMAITASHNPATYNGIKIFTEGGRDAEVEVTGPLQAHINTIADADIKALGRDEAVEQGLVRVQTSMNWYIDSILDQVDLDVIRHAHLKIVLDPMFGVSKTCLQTILLTARCDVDTIHERRDTLFGGRLPSPNSKTLKALAGVVVERGADLGIATDGDADRLGIIDDRGNFLHPNQILVLLYSYLLEEKGWIGPCVRNLATTHLLDRVAEAHGQTCYEVPVGFKWVSSKMAETGAVIGGESSGGLTVKGHIAGKDGVYAGTLLVEMIARKGKPLSQIYADIEKRYGRLEMIEDDFSFAPEAKEGLKKRIYIDQDLPDFDVEIDHISDMDGIKVYFANGGWIIVRFSGTEPLLRVFCEMPDAASAQRCIDAVVAKYGL
>NZ_CP019400.1|WP_015068986.1|2389421_2390543_+|sodium-ion-translocating-decarboxylase-subunit-beta
MDPTTWDNLLRGILNVQWQGLVMIAVGLLLIWLAIAKEYEPLLLLPIGAGCVLANMPVSSMLGEHGMLSIFYNVGVANELFPLLIFIGIGAMTDFGPLLENPKMVLLGAAGQFGIFLTLILALVLGFDRPEAASIGIIGAIDGPTSIYVSGKLAPGLLGPITVAAYSYMSLVPIIMPPVMRLLTTKKERTIRMAYSQRQISARTRIIFPIVVTIVVGILVPFALPLIGSLMLGNLMRESHVVERLTGAAQNELTNIVTLLLGLAIGSTMVGTQFLKVQTLMILVLGLVAFVLDTAAGVCFGKLLNVFSRDGFNPLIGAAGISAFPMAARVVQQEVSREDDGNFVLMHAMGANAAGQVASAMAGGVLLALMGSF
>NZ_CP019400.1|WP_028700776.1|2388936_2389419_+|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit
MRRYTITVAGTTHEIEVEETSATQFQVRVDGQQVEVELTAHQDVGDQPVVPQIDPRHESAPKAPRVPQQVRTRATGSPSPALTGGADLAYSMTAPMPGVIASVDAGPGDEVAKGQTVLVLEAMKMKNELHASRSGVIAEVLVAEGDQVKYGQTLLCFEKA
>NZ_CP019400.1|WP_015068995.1|2399482_2401201_-|ABC-transporter-family-substrate-binding-protein
MTHRSPAGRRPAARLTSAAAGLVALSLVAAGCSAGSSTGSDSSTPRSTAAIGKTDYNPQPYEKLKDGGSYTTAGSFSGDDTQGLPWNLNTTLTGSRIWSWYNPVAITYSPTGEVQINKDYYTGATAKTVGGKQVVTITINPKAQFNDGSPIDWHAIESTWKVANGSNKNFQVGSTNGYDQIESVRKGTDDRQAVITFSTPYTAWPALFSNFINPKAATVANFNGAYSNKLEPQWGAGPYTVSSYDPNSKKIVFTRNPKWWGRKGKLDKRIYLDYPNAQAQVNAYKNGQLDYTSVSTPEDLSEVKNVKGAQIRQGGSPFQYSLFLNGKSPILSDVAVRHAVLAAVDRKQIADIQFQGLDYSEPLRGSALYYGFQKGYQDNVAAVLKSGASEASKILEAAGWKKGSDGIRVKNGKPLTISYTIFSDTALDKATAASLAASEKKAGINLKITTLDASQWASTINGGKFDTVLSGNRSTDPFGSFNLSSTYGSKNAANITGVGSPALDKEISAVNAIPDPTKQVQQANQVERKALSLYGQLPLYSGPSTYSVKKGLANVGATLLYSPLPETIGYQK
>NZ_CP019400.1|WP_081685365.1|2401260_2402976_-|ABC-transporter-ATP-binding-protein
MADHRPPHHPQPGIPAHRQRHPRRCLHRPHRDLAVLPRVRHQAARRLPGCDAPGRIGRPDHRPVDLPGAVGGPGAPDRLGHPHRRRPARCPRPRLRPWRHPVTLLNVRDLHVTFESERGPVRAVRGVDLNLERGRTLWLVGIREPAKRASDFPHEFSGGMRQRVVIAMAVANNPDLIIADEPTTALDVTVQAQILETLRTAQRETGAGVLLITHNLGVVAGYADDVDVMYAGKVVEQAPVEPAFAAPRMPYTIGLLGAVPTVSSQEREPLTAIPGEPPQLAAEPTGCPFADRCPAAVEACRQGEPELRRVGPDHAAACVRADEIAAGTLDVASLFGRGPSPEQGVDRHESEEVLRVRGLVKTYPITKGAILRRTVGRTTAVRGVDLDLRAGETLGLVGESGSGKSSTLMELMRLAPPESGSVELLGTPITDDLTSADRSRIRSGVQLVMQDVSGSLSPRLTVYDILAEPLQVSGLGRSAIESRVYELLDLVGVDRSAVDRFPSAFSGGQRQRIGIARALALGPRVVILDEPVSALDMSVQAEVLNLLVHLQKRLAPVNGATHQVACHAAAA
>NZ_CP019400.1|WP_015068996.1|2402669_2403629_-|ABC-transporter-permease
MTALPPADAATIAAESAVTDGAAVAPTPDETGEFVRIGRRRILLRRFLRNPSAITGSIIFLLLIAFSIFGGLLTPYSYDQPDFLALTRPPGGQHPLDTTSGGNDLLAEVVHALQRSLVIAVSVSVITIILSAVIGAGAAYIGGRVEQIALAVIHFLLVVPSFLILALVSFRVGGDWKVLIVVLAVFGWMGTARVIWSVSTSLRERDYVRMAQIMGVSGWRIIVRHIIPNLGSLLIVNVTLGVVSTVLTETSLSFLGFGIKPPDVSLGVMLQDGSAALTTAPWIFLVPSVVLVLLTVSVTLIGDGLRDALDPDSARGGTL
>NZ_CP019400.1|WP_015068998.1|2404958_2405588_-|ArsR-family-transcriptional-regulator
MTENQHTLTDPGADSPADRVVEALRRRGGTASAAEVGADLGIHVSTARFHLDHLVEDGRARSGREKRATRGRPRTMFTLTPDPKEGPRAYQMLAGVLVDHLSRQDDAVALAHQAGVEWGRRYAGVDVTEILEQIGFAPCTTLVDDDQDEGPDGEARIALRHCPFIDVVQEHAALLCPLHRGVVEGVVGHPVTLEAHPGATCYVDLEQAG
>NZ_CP019400.1|WP_081583297.1|2405584_2408377_-|multicopper-oxidase-domain-containing-protein
MVLIQPIHTTGGPVPEITSRPQEDPGRPAPKGSDRTRRSAWHRKASAPVSVWLVALLAVVIGGHWIPQQRWLLVHMVTLGVATTSILVWGQYFTESILHEKLAEPDRKRQVWRIRILNLGVLACCVGMVPSWPWVVVAGATVVGLAMCWYALDLGLQVRRALPGRFDATVRFYSAAACLLPLGAIAGAVMAFSPEEPWRTRLLMAHQGLNIMGFVGLTAVGTLVTLWPTVLRTKMQPTQDRNGRRALWIMCAAVLVMTVGSLAGWWWLEAAGVLAELAGLCVVGVDLVRCAMKKPPRDFPGYSMGAAVIWFAIWLGWLAATILIKRDHLLQEDITALTVPVVVGFLLQLLLGAMSYLMPMVMGGGPAIVRATNARMHTLGALRATATNAGLVIWALAAGTWTSRIGLGLAILGMAGFLPAMVAMVKTGVGMLRAKRAAAEQKAPVPAADRADHSPEGRSGAPEPGKAAPASKMRTPTNHPAPAPTAPASRRSFAEAAIGLGAALGAVAVGRRLDGDTSGSGSSGHVTATGRTTTVKISMKDMHYHPSAVEVPAGNRLVVQLHNADPEQTHDLYFPSGAASRRLAPGQSQTVDAGVISAPTQGWCTIVGHRSMGMELEVTVGGASASQNGSSAATSTRRKIDLTKAPGAGFRTRDARLPALLAGRDHTMTLTVTESTQEVAPGATIRAMTYNGRVMGPAIHARIGDTMDVHLVNRGSMGHSIDFHAGTVSPNAVMRTISPGASLDYRFTLHRSGVWLYHCSTMPMSSHIAAGMYGAVVVPPHDLARADREYLLVQSETYLDAANGKEVDADKIAAETPDLTMFNGHANQYVFAPLTAKVGERVRIWVLAAGPSRGISFHVVGTQFDTVFKEGAYLLRPDNAEGGGAQALDLASAQGGFVEMVFEEPGRYTFVNHSFVEMERGARGLIEVIS
>NZ_CP019400.1|WP_028700782.1|2408330_2409401_-|hypothetical-protein
MVGAGFSLLASLDGALILLGVWSPVLTARLSQWHGPFMTLGFIGTVICLERAVALDRTWGYLAPLASGIGSILLASPAPVQIGLALLLLGQIGMLAIYIPLWRRSEDDATVIQAAGSACAVGAAGLLLAGVEVRSVIGWLSCYLVLTILGERLELSRLTMTRNRFLPAAALCLLAALVIQTASPKVGWPLLGVVLVVMSVWLIDKDVARVGMRRGGQAAYIGGMLMAGYVWLAIAGVVWIFSGPLGTGTGYDAAVHAVFLGFVMGMILGHAPIILPAVLRIRLDWSNWFWVPAVLLEASLVIRLGIGDGLGMPLAVQIGGTINVIALLSLIAVVVTHAHSRDGAHSAHPHDRRSRA
>NZ_CP019400.1|WP_015069001.1|2409536_2409911_-|DUF488-family-protein
MTTFQIANIRDDIREGSADSGYRVLVDRIWPRGVSKERAGLDEHRKEVAPSNELRKWFGHDPVRFDEFTAHYRAELDASGAAETFARDMAGHPLVTLLYGAKDHEHNQAVVLKQVLEELDGHTA
>NZ_CP019400.1|WP_015069002.1|2409933_2410422_-|DUF309-domain-containing-protein
MADRDRDAQGRPRNSRPRDGLGRPLPRGQEGVPVTPDDLELPGPETLEMAQELLDRGRPFHAHEVLEARWKNCPEAERDLWHGLAQLAVGVTHQMRGNTTGAIRLIGRGAMYLRPYATAAAPARVEEVDVAGILSWADATVTALEDGHGIDTVVTLRQKASS
>NZ_CP019400.1|WP_148279460.1|2410366_2412391_-|heavy-metal-translocating-P-type-ATPase
MRRRRMMSAIRRPGPRLAAAGILIAAALVMGRLGTDWALPGNIAMAAAAIISTIPIAAAALRALRSRTIGIDLLVTIASIGALAIGNYWEAAAVTFLFAFGHVLEQGAMTRTRSALTDLVRSAPQDAVLVRDGRTETVPTRTLRPDDVVLVAAGSSVPVDGTVISGSGAADESAVTGESMPAEKTPGDQVRSGTTLTSGMVQVRAEKVGSQTLLARIVARVEEAQDARGRVQTMMDRFGRWYTPAIIVLAIVVGLISGSLTLALTLLVIGCPGALVISVPVAVVAGIGRGARDGILIRGGEHLETAAKVDTVVFDKTGTLTTGHPELTDVVAYGAADEEEVLRWAALAEIGSGHPLAGPILDAARSHGVAPEGVPGEADAIPGRGLIADVLDAEHPQTRHRVVVGTVELAGQELGSDKESDTAWAARTSARLAGGGATPVTVVRDGVLLGVLAIADTIRADAPAALARLRRTGVTRLVMLSGDRQEVASAVADQLGIDDARGGLLPEDKLAAVQELRAGGAVVAMVGDGINDAPALAAADVGVAMGAAGSALAVETSDIALMADDLTRLPESLRLARRTRAVIRQNIVIAVATVTLLLAGVLLGGVTMALGMLVHEASVLVVIVNALRLLGRRARTREESRQDQAGKQDQPWQTSEHGGSRSGRPGASPQQQAA
>NZ_CP019400.1|WP_015069004.1|2412407_2412647_-|heavy-metal-associated-domain-containing-protein
MSTNEITTTHTVLRAEGFSCPSCVAKITGALEKLPGVGDVTVHFASGRIEADHDEARTSVDDLIAAVGKLGYPATASAF

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Crispr_ID: NZ_CP019400_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_9

2746992-2747085

Orphan

Consensus_repeat	Method
CCCGACTTGTTCGGGGGGTCAGCGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_9

>merge|NZ_CP019400|9|2746992-2747085|CRISPRCasFinder
CCCGACTTGTTCGGGGGGTCAGCGAGCGCTTGCGCGAGCGAAGGGGGTGTTTGACTCGGGCGCTGACCCCGACTTGTTCGGGGAGTCAGCGAGC

>NZ_CP019400|9|9|2746992-2747085|CRISPRCasFinder
CCCGACTTGTTCGGGGGGTCAGCGAGC	GCTTGCGCGAGCGAAGGGGGTGTTTGACTCGGGCGCTGAC
CCCGACTTGTTCGGGGAGTCAGCGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015069227.1\|2737413_2738025_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|100048
NZ_CP019400.1\|WP_015069237.1\|2749025_2749709_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP019400.1\|WP_028700526.1\|2745860_2746820_-\|1-phosphofructokinase-family-hexose-kinase	unknown	unknown	gnl\|CDD\|238570
NZ_CP019400.1\|WP_154662023.1\|2740332_2741781_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225844
NZ_CP019400.1\|WP_028700527.1\|2743692_2745771_-\|PTS-transporter-subunit-EIIA	unknown	unknown	gnl\|CDD\|182066
NZ_CP019400.1\|WP_028700530.1\|2739212_2740205_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP019400.1\|WP_015069241.1\|2751737_2753039_+\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749
NZ_CP019400.1\|WP_028700523.1\|2754533_2755679_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340825
NZ_CP019400.1\|WP_081685345.1\|2755796_2756933_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340828
NZ_CP019400.1\|WP_028700524.1\|2749806_2750649_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NZ_CP019400.1\|WP_028700531.1\|2734649_2735948_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340854
NZ_CP019400.1\|WP_028700528.1\|2743180_2743438_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|273389
NZ_CP019400.1\|WP_028700522.1\|2757000_2758065_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|376768
NZ_CP019400.1\|WP_051281628.1\|2735958_2737374_+\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|377422
NZ_CP019400.1\|WP_028700525.1\|2748114_2749029_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP019400.1\|WP_015069235.1\|2747117_2747885_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP019400.1\|WP_081685344.1\|2758125_2758629_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP019400.1\|WP_015069231.1\|2741896_2742853_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_051143461.1\|2750693_2751476_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP019400.1\|WP_015069228.1\|2738098_2739211_+\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	unknown	unknown	gnl\|CDD\|99740

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015069227.1\|2737413_2738025_+\|N-acetyltransferase	gnl\|CDD\|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	4.14207e-48
NZ_CP019400.1\|WP_015069237.1\|2749025_2749709_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	6.59075e-50
NZ_CP019400.1\|WP_028700526.1\|2745860_2746820_-\|1-phosphofructokinase-family-hexose-kinase	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	9.57927e-104
NZ_CP019400.1\|WP_154662023.1\|2740332_2741781_+\|hypothetical-protein	gnl\|CDD\|225844	COG3307, RfaL, Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane].	2.86796e-07
NZ_CP019400.1\|WP_028700525.1\|2748114_2749029_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	6.18799e-57
NZ_CP019400.1\|WP_028700530.1\|2739212_2740205_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	4.84284e-43
NZ_CP019400.1\|WP_015069241.1\|2751737_2753039_+\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	4.94567e-120
NZ_CP019400.1\|WP_028700523.1\|2754533_2755679_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	1.51446e-32
NZ_CP019400.1\|WP_081685345.1\|2755796_2756933_+\|glycosyltransferase	gnl\|CDD\|340828	cd03798, GT4_WlbH-like, Bordetella parapertussis WlbH and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.	5.922e-73
NZ_CP019400.1\|WP_028700524.1\|2749806_2750649_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.14255e-92
NZ_CP019400.1\|WP_028700531.1\|2734649_2735948_+\|glycosyltransferase	gnl\|CDD\|340854	cd04946, GT4_AmsK-like, amylovoran biosynthesis glycosyltransferase AmsK and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.	2.76595e-80
NZ_CP019400.1\|WP_028700528.1\|2743180_2743438_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|273389	TIGR01003, Phosphocarrier_protein_HPr, Phosphotransferase System HPr (HPr) Family. The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS].	1.07441e-15
NZ_CP019400.1\|WP_028700522.1\|2757000_2758065_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|376768	pfam02350, Epimerase_2, UDP-N-acetylglucosamine 2-epimerase. This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyzes the production of UDP-ManNAc from UDP-GlcNAc. Note that some of the enzymes is this family are bifunctional, in these instances Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of rat Gne is the kinase domain.	4.26458e-121
NZ_CP019400.1\|WP_051281628.1\|2735958_2737374_+\|O-antigen-ligase-family-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	4.79861e-07
NZ_CP019400.1\|WP_028700527.1\|2743692_2745771_-\|PTS-transporter-subunit-EIIA	gnl\|CDD\|182066	PRK09765, PRK09765, PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional.	7.41647e-124
NZ_CP019400.1\|WP_015069235.1\|2747117_2747885_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	7.10054e-78
NZ_CP019400.1\|WP_081685344.1\|2758125_2758629_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	4.0468e-20
NZ_CP019400.1\|WP_051143461.1\|2750693_2751476_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	5.38261e-154
NZ_CP019400.1\|WP_015069228.1\|2738098_2739211_+\|DegT/DnrJ/EryC1/StrS-family-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	1.15384e-155

>NZ_CP019400.1|WP_028700526.1|2745860_2746820_-|1-phosphofructokinase-family-hexose-kinase
MIVTVTPNPSLDRTAGLPGPIVRGQVHRFSGSTVVAAGKGVNISRGLHGAGVPTTTVVPAADHDPLLDGLIADGIPTVGVPVSEPVRVNLTVTEPDGTTTKFNDPGAHLTPAELAAFEDAVLAASDGADWVVMAGSLPPGMPTDWYAAMVPRIREHGARIAIDTSDAPLVALASNLPESAPDLVKPNSVELAQLCGGDGDAMEAEAAAGSFGPVIGAARDLIGWGIAEVMVTLGGAGALLVHKDRAWHAVAAPVEVKSTVGAGDSSLAGLLLGRSQGLADAECLRTAVSWGSAAASLPGSTTPTIEQAAAIQVTVRQLP
>NZ_CP019400.1|WP_028700527.1|2743692_2745771_-|PTS-transporter-subunit-EIIA
MSDSLIDPEIVVLDVDLGSTKQEVIRSLAGVVGESGRADGDGLARDAMAREELAPTGMPGGFAIPHCRSEAVNQPSLGFARLNPKVDFGGPDGPADLVFMICGAEGAGEDHMKLLTKLARALVKAEFVEELRQAPDADAVVSLIRGVIEPSEAPAAAPAPAPAAQQPETAEAADAVHIVAVTACPTGIAHTYMAADYLTAAGKEMGIDVKVEPQGSTGVEPLEDADIARADAVIFATDVGVREKARFAGKPVIESGVKRAVNEPKKMIEEAVAAAKDPHAHRVTADEGGESDASEDKSQLGWGKRIQQALMTGVSYMIPFVAAGGLLIALSFLVSGFQVAFISDYVMKTFSITNLPSYADLQAVTQLKDAPFTMAQIASLNHSGFLIFLGSALNVIGNLAFSFLVPALAGYIGFALADRPGIAPGFVAGAIAVSMSAGFLGGLIGGLIAGLIAMWIASWSVPKWLRGLMPVVIIPLLTSLITGLLMLFVLGRPIALLMKAMTNGLGNMPASLTIVLGIILGLMMCADLGGPINKTAYLFATAGLSVTDPASMKIMAAVMAAGMVPPLAMALSTVLRPKLYTKAERENGTAAWLLGASFISEGAIPFGAADPGRVLPSMMVGGAVTGALSMGLGAASKAPHGGIFVFFAIDRFWAFALAIIVGAIVSGLLVTFLKSRAARKKKAEEATALAAA
>NZ_CP019400.1|WP_028700528.1|2743180_2743438_-|HPr-family-phosphocarrier-protein
MAKKVVTVGSSVGLHARPAATISQEAAKLGSVVTLATEGHDPIDARSTLLIMTLGAGAGDYVTVEGDNEADVATVAALVAKDLDA
>NZ_CP019400.1|WP_015069231.1|2741896_2742853_-|hypothetical-protein
MSHEMDDAAARIRLVRDLVRNGVGPQALARGVRDGTWTRVRRGACVEGSLSDDAVVRHCELIAATIPLLKADSWVLSYTSAAVVLGLPVPYEGLESAWITRPGGRSAHRRQQLMTRVCEFEDDEIITVGGLAVTCPERTAIDMARQHGFPDGLMVADAVLRAGGSLTKMQELVVRSARRPGNRAAVRSVELASPVPESPGESKMRAHLARLGCPLPELQFTLRTPEGRFVSRNDFGWPEWKVVGEYDGMGKYTDLRRPGETIADVIAREKAREADIRDQGYEIARFMAKDLRQPEQAAARLLKLLRANGYTGTRPGGA
>NZ_CP019400.1|WP_154662023.1|2740332_2741781_+|hypothetical-protein
MSHDRARTTGAVRDAGEGVRARVGQWWRDDPVGACAEALLWLLFIVLTFISTDQAIASDRAYPMLLVVLGVAGAGCLVLGVLRRREGRSAVSGSGIGRPGWRALGLTALPFLAMLCWAGITIPFATHVALSNRFGPLVHIRLPMASMVVPLVEAALVVLVAVGLVVGIGRRRLPEALWRAFLVLAASTLISIVWQVATRHAMVRRAVDGKLMWRTSTQLGGQATYHLALLLGIGVAVDAIRRRYRVGVSWLIIAGLGLAIVLSGSRAGLICLGLFCVALFIWGRPAGGRGGGGRRRTLVGVLGLAALAVVAGALLWLRGGALVDHDRAQTWKVAWRAVTADPTTVIVGRGYATIWPWFATETGIVPGAIHGLRPGPFGKSLVHAHNTVVQVGGELGIIGLVLLLVSVVGVAVLAFRGIHGRHLGICLALLASLPALVLDTYLVKNFQVSLVWWLVAAAVAVLMARPADHDQPTNSDQPADRP
>NZ_CP019400.1|WP_028700530.1|2739212_2740205_+|Gfo/Idh/MocA-family-oxidoreductase
MANLRAGMVGIGSMGKNHVRNLRAIDGVDLVAIADASGKDPFGVAGDLPVLPDVDAVIKEGVDYCVVAAPTKFHEEIGLKLAEAGVHALIEKPLAYDTVAARRLADAFSSRGLVGAVGHIERYNPALQSLRKRLENGDLGDLYQIATRRQGPFPARIADVGVVKDLASHDIDLTSWVTQRDFELVAARTMFKAGREYEDMVSATCQLTGGLMSNHLVNWLTPTKERRTFVTGEKGMFIADTLTADLTFYANANVETVWDDIANFRGVAEGDVTRFAIPKPEPLRTEHENFRDAVLGKNSDIVTMTQGAKVVEVCEAMIRSAASNEFVQVG
>NZ_CP019400.1|WP_015069228.1|2738098_2739211_+|DegT/DnrJ/EryC1/StrS-family-aminotransferase
MTYEFIPPAKPIIGEDERKAVDAVLASGQVAQGPQVHAFEEEFSEQVADGVHAVAVNSGTSALHIGLLASGIGAGDEVIVPSFTFAATGNSVALSNAKPVFADVDPVTFTLDPASVEASITEKTAGILPVHLYGLPANMTALKEIADKHGLALFEDCAQAHAASIEGKHVGTFGTFGAFSFYPTKNMTAGEGGMITTPDAEVARKAAMIRNQGMEKRYANELVGLNNRMTDINAAIGRVQLTKLAGWTRTRQQNAEFLSANITEAVTPAVPEGYVHVYHQYTIRLEGATGAERDRFTAALKDEYQVGSGVYYPIPNHRLPSLAPYAPGLELPNTEKVASECVSLPVHPSLTQADLERVVEAVNACAKAGA
>NZ_CP019400.1|WP_015069227.1|2737413_2738025_+|N-acetyltransferase
MSEPRIIPTADLDDGVTIGDGSSVWHLSQVRSGAELGENVVVGRGAYIGEGVHVGDNCKIQNYALVYEPAYLEDGVFIGPAVVLTNDHFPRACNPDGSVKSADDWEPVGVTLKHGCSVGARSVCVAPVTIGEWATVAAGSVVVKDVAPYALVAGVPARRIKWVGRSGFPLESEGEHRWVDTRTGDHFVEDPETDTLTRLDESA
>NZ_CP019400.1|WP_051281628.1|2735958_2737374_+|O-antigen-ligase-family-protein
MSHTTSLLDTARVTGAEPGTLGARGRFLEFCLRWAFLLLPFASAWASTITLGPIAPVRALAAVMLVLVLLCRDRMTTVTWSVVLVGSLWLCWGVFLARPGTGYRELLGVGVGLATMVAMTMAAKDASWLIRLCRAWLIGMIIVCLPAFFEVATGIHMPNYREGSSEYVRTRATDIASFMVNPNLFAYFLIVGMGVMIVGWRLETGRLRWVYFGFALVTPVLVLLTGSRLCLAAVAVLFIWMMLLSRPLSLVVAAVGVLGVGLIVVSGRMQSLLKIVDTAMFNLGSLSGRSRMHVYQDALWMFVDKLGLGQGPGQFSVRLAYAPWPTYTTIDPHNGFTEVFVGYGMLVGALIVALALAALVRAVRRDWRAPTRRRPRPAAESVLLQGVVALLAVSPLLAMANSSYLKSPVVWCHMGTIAIWCQALLAARRWRLREDPSPLVTPARGKGTGLPRRYRLARRAAADRAVVRGHE
>NZ_CP019400.1|WP_028700531.1|2734649_2735948_+|glycosyltransferase
MGEASRPVIVLLTSRFPYGPGEQFIESELPHWAQAGVDLVVLPEKNDHPDSPVRPVPPGIDVDTRLTHRWEAPGWRALGLLDALRGPEIYRDLALLRRLGLLDLRHALYVLRTGVQVAVVRRMLRRIVAERGRIDVAYAYWLSVSADAAALERRGGGVRHAVAGSSGVRHAVARAHNADVYEERHPLRFHPLVRQIAPDLDLLLPIASDGGSHAVQCFGFSDQQVRVNRLGVSIPKPTDRCRPTGEGELTVVSVSTMTPFKRLDLLIDALAALADMRPGTHLTWRHFGAGRLHDELARRVEEVLEPRGVTVEWMGQVTNRELLDWYLEHRVDVLVNTSSSEGIPVSMMEAMARGVPVIGTDVGGVREILAEDWLMDADPTPEQVAGFIAERADAVKDPAVREEMAARIAERYDADANYRRFIATLTDLARRA
>NZ_CP019400.1|WP_015069235.1|2747117_2747885_-|DeoR/GlpR-transcriptional-regulator
MYPAERHKWLIDTATDEGRVSVSRASDELGVVPETIRRDLEYLASQGLLRRVHGGAIPASFDTLGDQPLDTRDSSAVSEKEAIAQAALAYLPADRGSIVLDAGSTTARLAALLPATSRFTVFTDSAPIASVVAARTACDVQLIGGRVRSTTQATVGNSRELERLRVDVAFIGTNGVSLTHGFSTPDIEEAATKAAMVSCAHTVVALVDSRKIGAESTARFAEISDVDVLITDEGISDRQRRGLEEEGLKVVVAVL
>NZ_CP019400.1|WP_028700525.1|2748114_2749029_-|amino-acid-ABC-transporter-permease
MSTTVLFDVPGPKALRRHRVIGIVGVLIGVALIAALIYGLRSQLGWDAWSAIFTGQAWADYFLPGIVNTVQAAAAALILASLLGLVLALGRMSFVRPVRWVCSVLVEFFRAVPVLMAMLFFYYLMVFAEPFATLVDPSLKGLVGVIAGLTFYNGAVMAELLRAGVSSLPKGQTEAGLAIGLSLGQTRRIILLPQAITAMMPALVSQLVIIVKDTALGYIITYPELLRSATNLSSGGTNIIPVFLVAALLFIIINYTLSRFAEHLQDRMRKRRGGKAVTIEEAHQGSFLADEGALEEAVDQHHHA
>NZ_CP019400.1|WP_015069237.1|2749025_2749709_-|amino-acid-ABC-transporter-permease
MSGLAELMREYDLLSGFWMTIKLTLVSALGALILGTVVAIMRVSPVKAFQVFGKGYVNIIRNTPLTVIVTFCALAFYNVLAWQLAGPNARSATQLFWWGVVALSVYHSTFVAEGIRSGINTVPVGQAEAARSVGLTFGQTLSQIILPQAMRGAITPLGNTLISLTKNTTVVSAIGVAEASYVMKNMIEFSPQFIYAIFLLMALGFVILTLPIGALVSWASTRLAVQR
>NZ_CP019400.1|WP_028700524.1|2749806_2750649_-|glutamate-ABC-transporter-substrate-binding-protein
MSLRKVAAAVGAAALSLSMLSGCVAGSDGSTSGSGDSSTAGSINIGIKYDQPGLGLKDGSAYKGFDVDVANYVAKDLGYSSVKFVETPSAQRETMLQSGQVKMIFATYSITAEREQKVSFAGPYFIAGQDLLVKSDNKDITGPDSLDGKKLCSVTGSTSAQKIKDTYSSKVDLQEYDTYSKCVAALSAGTIDAVTTDDIILAGFASQPQYKGKLKVVGKPFTTEKYGVGIKKGDTALAKKINASIKKMIDDGSWEKAVKANTPEFSYNKETNPPSPTSGQ
>NZ_CP019400.1|WP_051143461.1|2750693_2751476_-|amino-acid-ABC-transporter-ATP-binding-protein
MAAFNREDTGPLVHTIGETIVELSHVDKHFGDLHVLQDINLTVAKGEVVVVLGPSGSGKSTLCRTINRLETIDSGTITIDGTPLPSEGKPLAQLRAEVGMVFQSFNLFAHKTILENVMLGPLKVRKKPKAEAEKQARDILERVGVANQADKYPAQLSGGQQQRVAIARSLAMEPQVMLFDEPTSALDPEMVQEVLDVMVSLARGGMTMIVVTHEMGFARKAANRVVFMSDGQIVETADPESFFTNPTSDRARDFLGKILH
>NZ_CP019400.1|WP_015069241.1|2751737_2753039_+|nucleotide-sugar-dehydrogenase
MKIAVVAMGKIGLPLAVQFAEKGHDVVGVDVQQRVVDEVNKGNEPFPGEAFLDEKLKKLVPAGKLHATTDYAEAIPQADAVVLVVPLFVNDETWEPDFGWMDDATRSLAAHLSKDTIISYETTLPVGTTRNRWKPLIEEISGLKEGEDFTLVFSPERVLTGRVFADLRRYPKLVGGLSAEGTAKGIELYKQLLDFDDRPDLPRPNGVWDMGTAEAAEMAKLAETTYRDVNIGLANQFGKFADKNGIDVYKVIDACNSQPYSHIHRPGIAVGGHCIPVYPRLYLWTDPDASIVRTARQANMTMPQYCVDQAASVLGDLKGQKVVVLGASYRGKVKETAFSGVFPTVKILADAGAEVTVHDPMFTDAELEKFGFTPYHIGEAVDGALLQADHPEYKDLDPNDLPGIKVLVDGRHVVDPANWQGVEVIVVGDGEDR
>NZ_CP019400.1|WP_028700523.1|2754533_2755679_+|glycosyltransferase-family-4-protein
MTSPARVCHLSTVHNPRDNRVFRKECVSLAHAGVDVWFIGAQQGDEIVDGVHVVGVGEATGRLDRLTRRQFRAWQALDRISPDVVHVHDPELIPMVLAWRRLRGRAAVYDAHEDLIGQIEGKEYLADWVKPVARLAARGVISAADRFFDGIVASTPTVLSFYHNPNRAVVRNYPLLTDYPSSADAVKKDGQAVYAGMLSAGRQVDRMFEMIAQVPESHLTVAGEPDPEVRRFFEDLRPDQRVEWLGRIPGDQVPGVLAESQVGIAFFKPLKNYQEALPTKLFEYMAAGIPFISTDLPFLVELFSDRDCGVFVDTADGAQAAAEALRDLLADPDRCARMGADGRGAIEEEFSFEAEFPNLLKVEEAALRRQGARLRAEGAQS
>NZ_CP019400.1|WP_081685345.1|2755796_2756933_+|glycosyltransferase
MRILLVSAASSIHTVRWANGLAARGHEVHLASVHLPGKHPFSSDVKVHICPTHGSAGYLTGAAWLHRLEHQIRPDVVNVHYATGYGTLARMARLRTPVLLSVWGSDVYDFPRRNRLCAWLVRGNLASASRLASTSQAMAVVTRQYAPGRSISITPFGVDMNAFVPGPEPEPSDTVRIGTVKAMYAKYGIDDLIRAFAPVCSEHPQAELDLYGDGPDTEALKELAATLGVEEQVIFHGSVPHEQVPEALRKMDIFAALSTLDSESFGVAIIETGACGLPVVVSDVDGPAEVVEAGVTGFVVPRGDPAAAAEAFERLINEPELRLGMGRAGRRRVEAEYSWAHSLDLMEEAYAQAVEDAKCIPRNPARAVFGPRVAARRR
>NZ_CP019400.1|WP_028700522.1|2757000_2758065_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MRVVSIVGARPQFVKLAPVAKAFAQAGIEHRIIHTGQHYDVNMSDSFFVELGIPDPDLHLGVGGGSHGVMTGRMLEQLDPVLDDMAPDWVLVYGDTNSTIAGTLSAVKMHLPVAHLEAGLRSFNRRMPEEHNRVLTDHAADLCMAPTQVAMQHLADEGLAGRSVLVGDVMTDVCLQVRDSVLANPRPVPGVAEGEPYVMATIHRADNTDEQARLEHILDALGGLDRKVILPVHPRLRARAKADGIRIARGNLVTIDPLAYPDMVNAVVHADGVITDSGGLQKEAFLLGTVCTTVRTETEWTETVDNGWNVLDPGAEHLHETAVRPAPQADPGHPYGDGHAAVKVAEVLERAEQN
>NZ_CP019400.1|WP_081685344.1|2758125_2758629_-|GtrA-family-protein
MTEPGSRGPDTGAEGAAPEAADAQKPPSKGWRFRLARLIRFGLVGVANTAVYYLFYRILLIFWPYLAAHLVAWALSVVFSFLANCYFTYRVRPTWKKFLAFPATTLVNVAFSTLGSILLVEGLHVDDRYATVLAGIAAIPFTYLLTSTILTSQRLETQDRTPEQDEP

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Crispr_ID: NZ_CP019400_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_10

2778262-2778400

Orphan

Consensus_repeat	Method
CGGTCGGGTCCGTGGGAGGCGGGTCGGCACCCGTGGCCACGCGTTGCGGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_10

>merge|NZ_CP019400|10|2778262-2778400|CRISPRCasFinder
CGGTCGGGTCCGTGGGAGGCGGGTCGGCACCCGTGGCCACGCGTTGCGGGTGAAGTCCGTGGCCGTGCTTGGGGGCTGCCTCCCCGACGGTCGGGTCCGTGGGAGGTGGGTCGGCACCCGTGGCCACGCGTTGCGGGTG

>NZ_CP019400|10|10|2778262-2778400|CRISPRCasFinder
CGGTCGGGTCCGTGGGAGGCGGGTCGGCACCCGTGGCCACGCGTTGCGGGTG	AAGTCCGTGGCCGTGCTTGGGGGCTGCCTCCCCGA
CGGTCGGGTCCGTGGGAGGTGGGTCGGCACCCGTGGCCACGCGTTGCGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_051281618.1\|2781799_2782309_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP019400.1\|WP_028700512.1\|2773778_2774393_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239646
NZ_CP019400.1\|WP_028700508.1\|2780694_2781696_-\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176214
NZ_CP019400.1\|WP_028700507.1\|2782323_2782839_+\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NZ_CP019400.1\|WP_028700517.1\|2769267_2770401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028700505.1\|2783929_2784247_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP019400.1\|WP_076692607.1\|2779745_2780375_+\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|274058
NZ_CP019400.1\|WP_028700506.1\|2782877_2783888_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP019400.1\|WP_028700513.1\|2772298_2773648_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP019400.1\|WP_015069256.1\|2778511_2779048_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_154662022.1\|2770502_2770967_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028700515.1\|2770951_2771197_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015069255.1\|2777039_2778215_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340825
NZ_CP019400.1\|WP_036936328.1\|2784735_2786565_-\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|377746
NZ_CP019400.1\|WP_076692606.1\|2774389_2776936_+\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|273901
NZ_CP019400.1\|WP_081685342.1\|2765173_2767411_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380193
NZ_CP019400.1\|WP_028700509.1\|2780350_2780671_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028700510.1\|2779079_2779697_-\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|234840
NZ_CP019400.1\|WP_028700518.1\|2767462_2768908_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369025
NZ_CP019400.1\|WP_028700514.1\|2771327_2772158_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_051281618.1\|2781799_2782309_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.07514e-20
NZ_CP019400.1\|WP_028700512.1\|2773778_2774393_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.60953e-27
NZ_CP019400.1\|WP_028700510.1\|2779079_2779697_-\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|234840	PRK00802, PRK00802, DNA-3-methyladenine glycosylase.	2.12282e-84
NZ_CP019400.1\|WP_028700507.1\|2782323_2782839_+\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	1.29832e-67
NZ_CP019400.1\|WP_028700505.1\|2783929_2784247_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	4.86712e-44
NZ_CP019400.1\|WP_076692607.1\|2779745_2780375_+\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|274058	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase. This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing].	4.54527e-24
NZ_CP019400.1\|WP_028700506.1\|2782877_2783888_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	2.62337e-146
NZ_CP019400.1\|WP_028700513.1\|2772298_2773648_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	5.45347e-117
NZ_CP019400.1\|WP_015069255.1\|2777039_2778215_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	1.59766e-77
NZ_CP019400.1\|WP_036936328.1\|2784735_2786565_-\|Na+/H+-antiporter-NhaA	gnl\|CDD\|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	1.07282e-149
NZ_CP019400.1\|WP_076692606.1\|2774389_2776936_+\|ATP-dependent-helicase-HrpB	gnl\|CDD\|273901	TIGR01970, ATP-dependent_RNA_helicase_HrpB, ATP-dependent helicase HrpB. This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity].	9.58995e-178
NZ_CP019400.1\|WP_081685342.1\|2765173_2767411_-\|hypothetical-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	7.88021e-37
NZ_CP019400.1\|WP_028700508.1\|2780694_2781696_-\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176214	cd08252, AL_MDR, Arginate lyase and other MDR family members. This group contains a structure identified as an arginate lyase. Other members are identified quinone reductases, alginate lyases, and other proteins related to the zinc-dependent dehydrogenases/reductases. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.66493e-157
NZ_CP019400.1\|WP_028700518.1\|2767462_2768908_-\|hypothetical-protein	gnl\|CDD\|369025	pfam06662, C5-epim_C, D-glucuronyl C5-epimerase C-terminus. This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.	1.10573e-06
NZ_CP019400.1\|WP_028700514.1\|2771327_2772158_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	1.15542e-74

>NZ_CP019400.1|WP_015069255.1|2777039_2778215_+|glycosyltransferase-family-4-protein
MPNRRVTVINHYAFPPGSGGITRNFDMFSRLKNWTPHFFAANINHTSGQKMTVDDPRYTLVPIPEYQGNGVKRMLGWVAFAAGAGARALVRPADVIFASSPQILAPAAAMVVAKLRRKPFVVEIRDLWPDSLVSGGAVKEGSLLHKVLVGLERTIYANARRIVVVPTGWEDHFRELGIDVDKITVVPNGADLAEYDVPESKEELRSRYGISGFTAVFSGTHANYVGLDLIVDAAEKLPDVNFLLVGSGARKQWAVDEVASRGLANVTFHDQVPKSELVRILKACDVGLHTVTPQEVFNKGMSPNKLYDYMAAGLAVVSNAKVPLRDVIVDDEVGAVVEPYDLVEGISRVRDADEATMERWHAKARDLMADRFSLQASVDKLETVLDKSLYR
>NZ_CP019400.1|WP_076692606.1|2774389_2776936_+|ATP-dependent-helicase-HrpB
MIDLERIGAGLPVADHADRLRDALAGRRLVVQAPPGTGKTTFVPPLVATTVPGRVVVTQPRRIAARAAARRLASLTGTRAGALAAHTVRGESTLTPSTRVEFVTTGVLVQRLLRDPELIGVDAVILDEVHERHLDADLALAMVCELAELRDDLTVAAMSATLDAPMWAGLLGDGSTGEGGPAPVVEIPSVLHPLEVRWAPTPGSATDARGVRRAFIDHVVAQTALAFAAEEPAEREEGNGALVFMPGAREVDAVVAGLRGRDDLAGVDVMALYGRMDARAQDAALKPSDRPRIVVATSVAESSLTVPGVRLVIDSGLSREPRLDRGRQMTGLVTVRESQASATQRAGRAARLGPGVAVRCLRHEDWAGMAPEAPPEAEHADLVGPLLTLACWGTPRGEGMALPGALPPDRVAEAEEELRGLGAVDAEGRATPRGRDLAQIPADPRLARALTDARGIGSRAVAEVVAMLASDEPAADGDLVALLRALRSGRHPGSRSWKQQARRLESLVPRAAAAETTADVQVGTVVALAHPGWIARRRDNGGYLLVSGTGADLPRGSSLTGQEWLAVAETSRVAGRGSGALIRAAVPIDEGLALEAAAGYEVTEDRARWRAGRVSGRRVHRLGAVTLTSTPVKATRAAARRAVADALAEEGLGIDGHGVFTWSRGAIELRRRLGLLHRVIGGPWPAMDEDSLAARAEEWLGPELDALARGRGAGGASMASALRRLLPWPAAAHLDELVPESVVVPTGSHIRLEYPEVGSDLAPVLAVKLQECFGWTTGPTVCDGRVRVVLHLLSPARRPLAVTDDLASFWVNAYPQVRAENRGRYIKHPWPEDPLTAPPQRGTKKSGR
>NZ_CP019400.1|WP_028700512.1|2773778_2774393_+|NUDIX-domain-containing-protein
MAHLNTEPHGHDVTISAWIFRQVDGVTKALVHKHRKMGIWLQPGGHIEHTENPWQALVHEMREETGYEPEQYAVLQPLPRMRDGVHDVMHPVPAVMNTHSPYQGHFHSDLIMVLTTDEDPAHEPRPGESRAMAWLSPQEYASHEDAEPDAVAIMTMLAEKVVGHWYRTPATDWSLADAEPDPLTDRTPEQATAPDPEDDRETSW
>NZ_CP019400.1|WP_028700513.1|2772298_2773648_-|NAD(P)/FAD-dependent-oxidoreductase
MPALFSRFGYDPAFTKDRPKVAVVGGGFGGMAAAKALAAEGCHVTIIDKNPYTTFQPLLYQVATGGLNPGDVTYRLRSFTAKLGAHARFRRASVTDIDTDARLVHVDNGEPIPYDYVVLAQGVGANFFGIPGAAERSDTIYTRASSLRARDVIFSHLEALDTDKTRSFDVIIVGGGPTGVETAGTLAEMKSVGIPAIFPDVSIDRVHVTLVEMGPHLLAPFDAGLRHYTRKQLQRRGVDVRTETAIKEIREDSVLLGDGQTLPADMVIWAAGVGAHKKAVGWGFETGRGGRIVTDKNLRVHGQDRIFAVGDGAIIDENPLPQLAQPAIQEGELVASQVVHLERGEALQEFSYVDKGTMATIGRNAAVVELANGPKFTGFPAWLVWVMIHIYSLLGGRNRIQAMVNLGSRYLTFNREAGAIVGDVLTEDGEPESQKPESERPAASSKADD
>NZ_CP019400.1|WP_028700514.1|2771327_2772158_+|sulfurtransferase
MTPLLPTPLVSVDDLSDALAGPDGRRIVILDVSMGASAADPHIPGALRFDLDGPMSDQSTGLPHTMPAPDVLQESLRGLGISADSHVIVTETDFLFAAARPWWMLRAMGVDAVSILDGGNPAWERAGHPLVTEETPEPAPGDLVVEPRPGLLVDEEHVKRSLAAGETVVDARSRARFAGIEPEPRPGLRAGHMPGAVNLPYTELQREGRLLPVVDLASAVDRTAGRGPIVASCGSGVTACIVALAAVISGRDDVAVYDGSWSEWGRQGGPAVVTGC
>NZ_CP019400.1|WP_028700515.1|2770951_2771197_-|hypothetical-protein
MSRNTFVAVAAVVLAGGIVIARSRRSGRSSSEVGDKDLRHLQKRKPTGGRRTRRADPYADGHATPAGGDTRPKGAPAYFKA
>NZ_CP019400.1|WP_154662022.1|2770502_2770967_+|hypothetical-protein
MDSTPLVSRRLSLAAALLPWVTVVVPIRSTWKDLAVEEFLLDEGSIGLLAMTLLFGVTAVLALVPAARRWWGWCAAGVSLASAVVLAVYTVPGQVNWDGVDSQGRPTGGVELILPDFGWGILVLAWAAMTAAAVIALVTRRRAASARASGQALK
>NZ_CP019400.1|WP_028700517.1|2769267_2770401_+|hypothetical-protein
MRSSGTPREALVTAGAGVGLWLVQRVAVVVIWLIQGGSLPGDLMKWDAQWYARIAAGGYHWPVPQPGHTDPWLSDLAFFPGFPALTRAGTLGGLDARWATLVVAWIGFACAAGVIALVGREVGGAWTGVLLVLLWGAAPRSLVQILGYSEGWFIALVGLGLLMGLRRQWIRAGLAICVAGVIRPAVVPMGVLLGLAWVAAWPVFRRGVDSGERRRRFLGAALTPWGFLAYTVVVAHRTGRWDGYLLVQRAWGSSLGWSNEMFHQVREYWPIAPYNWTYFGLVAASVILYAALLVAMIAMREKPLLWGQVALVLLLTVFSVGYFQSKARFLLPAFPAFLPVARLLEKAPRWLCVATMVVITGLSTWWSIYVLGGRYSP
>NZ_CP019400.1|WP_028700518.1|2767462_2768908_-|hypothetical-protein
MNPAEHRMTRRAMLAGTAALVGATTLMSTSPSRAQADNTFFKTFGGSVVPLPAGPRQTLSDGYIGALRIGPDGVPLTQLNGGWVIHPTILGNYLNSLLNSYETVSGGQPKNLARVVTTMEALLARAARRNGAVFLKYEFPWHAFNGDLPDPWYSSFGQSKFPQVAWRLWKITGERRWLQACRELVQAFYEGPVPGKTGLPWIAKVDPNHNLWLDEYPTPSGRESAVFNGHYYALHELSVYSQLSGDAQAQKLVSGAVQTLADYRNLCRHAGTFSHYFASTSANVPSYHYINTSCYLNVYNNTGWAPFATTVDQMISDWRFTEGKSAQLYLSGGYNHTIRKVTGSAGANAGSATTWKPGSNMVVASGARTQYVAFNGVWSRMDSGPRKGYWLLESIYGYPEGFDTDRCEYRFPRVLYFEKGKVTTFIADSRGHMTNPRVTTFNARSSAHTSLRAKVNGRQYAKLTDGSFAGRWAPLGGTVHF
>NZ_CP019400.1|WP_081685342.1|2765173_2767411_-|hypothetical-protein
MRMSHAVTSATLCLGLIAAGTFYGPASPARAEGPSQPVITSVDTHVTSTAGGALVRLHGSGLTSDAMVKISGRSAEVRSASGGTMTVIAPAAPRGVAHIQVTTAGRTSDTNSTTAIAYVDQIPGTRPKARTTTDRTRLRPRSVTTAISDSNLALCVNDQLGLDPSTPPTPEQLSSLTALYCTDRTINSLAGISLLTNLQTLDVGGNTITDIGPLASMTGLKELGLQSNRVADLTPLSALTSLTRLDAWTNPVSSLAPLKSLTNLGYLDVSDTGVSSLEPLTGLTRLISLDANFTTVSSLTPLRSAAGLQELQLWQARVSDLTPLAGLTSLRYLDVSANRVTGITTLSRLTRLETLNLEDNDVADATALAGLTRMYSLNLSGNRISSVAPLAKLSALQWLFVQRNRIADLSPLSGLKPNSIEAQDQTVAAPVTTGKYTTFRMADRTGTSVTASGGFASYSGGRITFAHAGTTILSFRNSNATFTGTVLASCTYNIPMVTGDGTGDRIADLYGIGGDGKLHFFRGSATGGVSALPDPWQDAADATALVQIPDVNGDKRSDLLAREPDGQLLMRTGLGNGYLGTAKKFGTGWTSMDLIISAGHLSATSSNFLLARRHSDGSLVRYTLTSSGLSGTTIVGWRWGSMRAIIGAPDWNGDGRDDVLAIRDDGTLWLYTSSVRGTPNPGVRVGLGWSNFSTVTSPGDISGDGRSDLVAQRKDGVLFAYHLANRRFASPREIGRGLQDYRLIG
>NZ_CP019400.1|WP_015069256.1|2778511_2779048_+|hypothetical-protein
MAHNAYKALSRVFSVVLPAAGAGLIAGGRFAHQYVADQLAGQRITMPGGKDLPTEEMKSALARYSGLPMTTGPQAEAYANHYIGAHLAAAAKGRTYEEISQEYMAASADPDRKDTQEAADLGQLKEMLFTGSSLRGMLLNAYGWWTVGSIASWAGVGATGLGAVLAVPGWARRRGHRA
>NZ_CP019400.1|WP_028700510.1|2779079_2779697_-|DNA-3-methyladenine-glycosylase
MIDLSQPALDVAPLLLGAVISHTVVLDDGSRAEVRIRLTEVEAYMGPDDPASHAFRGPTPRTAVMFGPPSHLYVYLSYGIHRCVNVVCSPDGRASAVLLRAGEVVSGEDLARRRRSGAARQVPDRRLACGPGNLGQALGAGLSDSGAVLWQSEGLCPPPEAATWRLEPPGSPTPCSRSRRVGISHNAEKLWRFTIPDDPTVSRPR
>NZ_CP019400.1|WP_076692607.1|2779745_2780375_+|RNA-2',3'-cyclic-phosphodiesterase
MGHRMYAALVPPAEVLEAVDATLERMAERTSPGDPRRLRWSRPGDAHITLVFMADVDDPDTLIDALAASLADQPPVAVGLAGAGAFPQPGRARILWLGVNDPADTLPALARRARSAARGAGGRPKSGRFSPHVTAARAHDADVTGEIEALSSFSTPMWVARSVTVFESHLPNPSRGGRRGGGGGVRHEPVAQIGLEGIPRRSQFRSPNQ
>NZ_CP019400.1|WP_028700509.1|2780350_2780671_-|hypothetical-protein
MKNCLKDPESLSTAPVVAAGLIGGWQVARATGVRPIGGVVLAAAGVLAGRSWWARKGAATAVGLSAAYLGAFGASHPLAKRIGAWPSVLTVTAAAAGAAYWFGDRN
>NZ_CP019400.1|WP_028700508.1|2780694_2781696_-|zinc-binding-alcohol-dehydrogenase-family-protein
MHMPAVAARALPITNPDSLVDVTVPVPTPGPNDLLVEVRAVSVNPIDIKLRNGAGTPEQPLILGFDAVGTVVAVGEAVEGFSVGDEVWHSGDRTRPGTYARFTLIDHRVAAMRPGTLAAAQAAALPLTAITASEALREHMRLGGNDSFLMIGGAGGVGSIAVQLAKLLTDGPVVATASHDESADWCLKLGADAVIDHRRPLPDQAAEIGVDGFDGVLSPHTVGKVAELAEVMAPFGHLVTIDGLPDFDILAFKPKSLTVTSESMFTRTQFHTPDIAEQGRILARVAELVDSGKVKTTMTTRLQGINAATLRKATEMVEQGHMIGKVVVEADAW
>NZ_CP019400.1|WP_051281618.1|2781799_2782309_+|MarR-family-transcriptional-regulator
MDEESTRIGTVTDLVEQTEPLEQMVCFAMYSATQATVQYYRDVLAPFGITYQQFLVLVELNLAGRQSPTHLADALHLDCSSVSGLLNRMERSGLVERIRDDKDRRAVSVAATDRSREIFSRLGFLGGCVSGAMGLEPDEMRALLKALHKVRDAMVSAPRPQPEPELVTA
>NZ_CP019400.1|WP_028700507.1|2782323_2782839_+|glutathione-peroxidase
MTTTQARQTVDLKDLPVTTLQGEHTTFGDIVGDRTALVVNVASRCGLSPQYEQLEALQKKYADRGFTVIGFPCRQFLGQELKSEKAIEEYCSTTWGVTFPMSARIKVNGSQTDPIYVQLKDFPRQEDGKDGRITWNFEKFVVSRDGHVTRFSPTTKPDEPQVINAIEKTLS
>NZ_CP019400.1|WP_028700506.1|2782877_2783888_+|thioredoxin-disulfide-reductase
MRDVIIIGSGPAGLTAAIYAARANLNPLLIASSVDVGGELMQTTEVENFPGFPDGIQGPDLMAAMQAQAEKFGTEVVYDDVAALDITGPVKKVTVGEGDTFEARTLIYATGSAYRKLGIDRETELSGRGISWCATCDGAFFRDRHVAVIGGGDSAMEEATFLSRFASKVTVIHRRDALRASAAMIERAKADPKIEFHWNSTVADFLGDQKVDGMRLRDTVTGDTEEMPIDGVFEAIGADPRTHLVHGVLDLTDAGTIAVDGRSSRTSVPGVFAAGDVIDPTYKQAATAAGSGVVAALDVQAYLATLDDAKTAQIDDAGNTEAAQSVVAEDTVPAAV
>NZ_CP019400.1|WP_028700505.1|2783929_2784247_+|thioredoxin
MSINVTDASFETDVLKSDKTVVVDFWATWCGPCRQVSPILDRIADEHSDKITLAKIDVDANPGIAQQYGITSIPAIFVFKDGELAKTTVGAKPKPVLERELAEFL
>NZ_CP019400.1|WP_036936328.1|2784735_2786565_-|Na+/H+-antiporter-NhaA
MDRNPENQNLQPLRRSMRIHRWLTNDIYAAIALALATVAALLWANIGSSYETFWHSHFGFILGSLDFELTLHEWVDEGIMAIFFFMVGLDVRRDLTLGELRSKRRAVLPIAAALGGLIVPAALFLIIEGGSEGAAAWGAVISTDTAFAVGMLAVVAPRNAPRLRVFLLALAVIDDIAALTVIAIFYTTDLNLIALGLATLGLIGVWLLERANVWRVGPYLVLALYTWGCFFASGVHATLAGVLIALLMPVYPPRRSDLQTASHVFDLFHQAPQPDMAKRAREALTFSVPMNQRLSSAIAPYVNYLVVPLFALANAGVVLSGDSLSTAFTSRLTWGLIAGLVVGKAIGITLASMLVLKLSPGSRLPGLDAPRIAGVGALSGMGFTISLLVAGMALDDPAATDQARVGIIAASLLALGLSWTIFRLSKKFNPLPPPSDAHLARDVDPEADHIRGPVDAPATLVVYASMNYTYRRQTAIAVSQTRAALGDQLRVVLRHAPVDDAAVTGALALEAAGSQGKFWEMHDEMLGIRGPLDSDLVREAAERIGLDVGRFERRIEKQTDRERVDDDGLDLAGFETSEKPVIYLNGERVANAANSLTLTLGARKALAGA

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Crispr_ID: NZ_CP019400_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_11

2917808-2917895

Orphan

Consensus_repeat	Method
GGGCCGGGCTCGGTCACAGACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_11

>merge|NZ_CP019400|11|2917808-2917895|CRISPRCasFinder
GGGCCGGGCTCGGTCACAGACCCAACCTGTTCGGGGAGGAAGCGAGCGCCTGCGCGAGCGTGGAGGGGCTGGGCTCGGTCACAGACCC

>NZ_CP019400|11|11|2917808-2917895|CRISPRCasFinder
GGGCCGGGCTCGGTCACAGACCC	AACCTGTTCGGGGAGGAAGCGAGCGCCTGCGCGAGCGTGGAG
GGGCTGGGCTCGGTCACAGACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015069352.1\|2909145_2910762_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226089
NZ_CP019400.1\|WP_028701399.1\|2914429_2917351_+\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090
NZ_CP019400.1\|WP_015069353.1\|2910792_2912166_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP019400.1\|WP_015069348.1\|2905865_2907239_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP019400.1\|WP_015069362.1\|2920421_2922254_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|366567
NZ_CP019400.1\|WP_081583319.1\|2907399_2908170_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375436
NZ_CP019400.1\|WP_015069351.1\|2908162_2909149_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP019400.1\|WP_015069359.1\|2918023_2918644_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP019400.1\|WP_081685415.1\|2912155_2912941_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225140
NZ_CP019400.1\|WP_015069355.1\|2913182_2913545_-\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP019400.1\|WP_028701398.1\|2923810_2926552_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|376899
NZ_CP019400.1\|WP_028701396.1\|2929044_2929863_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NZ_CP019400.1\|WP_015069361.1\|2919053_2920277_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP019400.1\|WP_015069363.1\|2922408_2923035_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP019400.1\|WP_015069360.1\|2918702_2919017_+\|thiamine-binding-protein	unknown	unknown	gnl\|CDD\|376658
NZ_CP019400.1\|WP_015069367.1\|2928241_2929045_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|369792
NZ_CP019400.1\|WP_015069356.1\|2913840_2914197_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015069364.1\|2923031_2923811_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP019400.1\|WP_015069358.1\|2917450_2917780_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NZ_CP019400.1\|WP_154662072.1\|2926426_2928085_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015069352.1\|2909145_2910762_+\|ABC-transporter-permease	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	4.8403e-93
NZ_CP019400.1\|WP_028701399.1\|2914429_2917351_+\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP019400.1\|WP_015069353.1\|2910792_2912166_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.40872e-39
NZ_CP019400.1\|WP_015069348.1\|2905865_2907239_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.41906e-37
NZ_CP019400.1\|WP_015069362.1\|2920421_2922254_-\|beta-galactosidase	gnl\|CDD\|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	2.12659e-128
NZ_CP019400.1\|WP_081583319.1\|2907399_2908170_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|375436	pfam17933, TetR_C_25, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in Rv1219c of Mycobacterium tuberculosis. Structural studies indicate that the helix alpha 10 of the C-terminal end of Rv1219c forms a long arm feature, a feature which is unique in Rv1219c compared to some other members of the TetR family. Furthermore, it has been shown that substrate binding occurs in the C-terminal regulatory domain of Rv1219c.	2.95487e-27
NZ_CP019400.1\|WP_015069351.1\|2908162_2909149_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.15477e-78
NZ_CP019400.1\|WP_015069359.1\|2918023_2918644_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	2.79453e-119
NZ_CP019400.1\|WP_081685415.1\|2912155_2912941_-\|hypothetical-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	5.04512e-54
NZ_CP019400.1\|WP_015069355.1\|2913182_2913545_-\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	3.37372e-22
NZ_CP019400.1\|WP_028701398.1\|2923810_2926552_+\|FtsX-like-permease-family-protein	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	3.59947e-08
NZ_CP019400.1\|WP_015069361.1\|2919053_2920277_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.08522e-58
NZ_CP019400.1\|WP_015069363.1\|2922408_2923035_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.112e-16
NZ_CP019400.1\|WP_015069367.1\|2928241_2929045_+\|HAD-family-phosphatase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	7.7484e-43
NZ_CP019400.1\|WP_154662072.1\|2926426_2928085_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	1.7195e-42
NZ_CP019400.1\|WP_015069364.1\|2923031_2923811_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.08732e-104
NZ_CP019400.1\|WP_015069360.1\|2918702_2919017_+\|thiamine-binding-protein	gnl\|CDD\|376658	pfam01910, Thiamine_BP, Thiamine-binding protein. The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structure suggests a role in protein-protein interactions possibly regulated by the binding of small-molecule ligands. Solution of the structure of the hyperthermophilic anaerobic Thermotoga maritima sequence, UniProtKB:Q9WYV6, shows that this has a beta-alpha-beta-beta-alpha-beta ferredoxin-like fold and assembles as a homotetramer. It was possible to identify a pocket in each monmer that bound an unidentified ligand. It was also found that it bound charged thiamine though not hydroxymethyl pyrimidine. It is proposed that it is transporting charged thiamine around the cytoplasm. Under oxidative conditions this bacterium is under stress, and the transcriiptional unit within which this protein is expressed is up-regulated in these conditions, suggesting that the chelation of cytoplasmic thaimine is part of the response mechanism to such oxidatvie stress, which is mediated by this family.	2.91823e-31
NZ_CP019400.1\|WP_028701396.1\|2929044_2929863_+\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.06059e-52
NZ_CP019400.1\|WP_015069358.1\|2917450_2917780_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	1.47163e-30

>NZ_CP019400.1|WP_015069358.1|2917450_2917780_+|YbaB/EbfC-family-nucleoid-associated-protein
MTTPEGGFDMSGFDMNGLLAQAQAMQAQLAQAQQELAAATFEGSAGGGLVTATVSGSGELQALVIKPEAVDPEDTETLSDLIVAAVRDASAKAAAKQASLVPKIPGLGM
>NZ_CP019400.1|WP_028701399.1|2914429_2917351_+|DNA-polymerase-III-subunit-gamma-and-tau
MADEPSDDDRLDEYVQDGPDLFGGEPEPAEPGAGAEPTPADDVEEEPDDGPVDAFSGPETPLEPEGLDSEEDVDPDDLIVPEVEEPEPEPEDEPDAGPVDVPSDDVPEPPLALYRRYRPETFDEVIGQEHVTEPLKRAILNNRVNHAYLFSGPRGCGKTTSARILARALNCEKGPTPTPCGVCQSCRDLGRGGPGSIDVIEIDAASHGGVDDARDLRERAFFAPVASRYKIYIIDEAHMVTTQGFNAMLKLVEEPPPHVKFIFATTEPEKVIGTIRSRTHHYPFRLVPPKTLVTYLEQICQQEGIAVDHAVLPLVVRAGGGSVRDSLSVLDQLLGGAQADGVSYEQAAALLGYTPDALLDQIVDAFAAGDAHEVFATIDKVIEVGQDPRRFAEDLLRRMRDLVILAAVPDACTSGLIDVSPEQAGRLSHQVAGLGSGELTRAAEVLATGLTQMRGTTAPRLHLELMCSRILLPGADAGDRGYSARLERLERRMGMGDGVAGEMPAAPVPVTPVQSTGSAAPVASAETSQPSRTAGGETPQSRWQESPRQASPQPPQELDTSGAGAPPPRSSGASATSPQQPSQPRRRPRPSSRDYAPGGQGPEARRDQPQARPQENRPEQPRQDRSRQESPSSPRPDAGPRPGEQASGPAPSGQGQVDIAMVRRAWPQVLDVVRGRRKVAWMVLSQYAQVVEVHGRSATIAFANPGARQMFESGPDQATLHDAVVEVLGVDLTFTPVLGGGQGPAGPAPSGPSQPEPYSAGPGGGSGPGYGSEPGGPQEAPPDPSEPGRDQTDRDRAVDGPVGVVVDPAGGVPVPARDAADRESVAARPDSPVPAPDSTPISDGVRASAPSPAGVPMPSSGPSPSSGPSPASGPSPASASTPPERAAGDPAGGKDAGAIDDAAHHVMTHRWSARAKENIRAMSHRVDEAPPEEPPEEADWTDSEIVEAPQQSPAQLIMAELGGVVIDDPLAEQ
>NZ_CP019400.1|WP_015069356.1|2913840_2914197_+|hypothetical-protein
MTERRIITTNRAGVIWSGITWVCVLLFLPAGLASMAMQTLLPANLGYPQLDAPSGVPVWLNRTVLVLDILVFVIPPLVVTLANKKAKRLGHRVKGVVAGSWAVAGLVAAIALMLWFFG
>NZ_CP019400.1|WP_015069355.1|2913182_2913545_-|RNA-binding-S4-domain-containing-protein
MTRIDVWLWSVRAFKTRSLATNAVKGGHIRLNDDPVKPAKEVKPGDLVTIKTPGWDRVLKVVQPIGRRVGAKIAVEAYEDISAPRPEWLSAPMARRDRGAGRPTKKDRREIERLRGRENR
>NZ_CP019400.1|WP_081685415.1|2912155_2912941_-|hypothetical-protein
MRTPGPRTASATAPRSIGPMPTTLDLRDLPAALRAHLGPRTAWWTVRSPFEILVGCVLVQNTNWRNVEGSLAGLRDASVDSPADLLNTTTPELTALIRSSGFQTSKERALRGLCGWWATRLGGTGPAIKAPVEASALLATSALLPETPTPQLRAELLGLRGIGPETADVIMLYLLGRGVFVSDTYARRLLTRLGLAVPRSYNALARLVTRQVDLDLAGWQEFHGLIDDYGKQYCTGDAAWERGPLAGHRLAPKDGGAVHAR
>NZ_CP019400.1|WP_015069353.1|2910792_2912166_-|APC-family-permease
MPVDRLTAPPRRDHRPDRRGDGGLRRSLTLPTLIVYGLLFIGPTSPMGTFGVLDARSHGAIGLVFIIATLAVAFTAWSYARMSRAVPLAGSVFAYASAGLGRRPGFIAGWMLGLDYLFMPSMMSLILGIAAHHLVPSVPAWVFTAAGIVLMTGLNLAGIRTTTTVSFIILGVEIVMLAVFVVAAVVVLATHGPQRGWLSPLTGVGPFDPAGVIGAVSIAVLSFLGFDGIASFAEETTGSSRQVSRALVVCLVLAGALFVVQTYLAALLSPRTPGYLAAHQGEQGTDFYQLLDSQIGTWLGTTVTVVKAIGPVFSAMVAQAAASRLMYGMARDGALPRPLARIDRRTRTPRNAVLVTAVLTLSISVSAAIRPDGLDLLSSLVTVGALVGFLFLHAAVIGYFVCGRRTSHRAAHIVIPVIGGLIIATVLALAAHPALVVAGIWLAIGLAALAVRERTAG
>NZ_CP019400.1|WP_015069352.1|2909145_2910762_+|ABC-transporter-permease
MTPLTGTLRLLGWGLRRDRLRIGMWCLGVGLTAGATVPAVRDAYPDAAARIARAEISRMPGTVVMTGPFFGAGPSGSAHDPGVGAVVVSEIGMFLLVAVAIMSILAAVSHTRGDEEAGRTELVRALPTGRAAPASAAMLLVVLMNALVAAVVAGCLVATGLDLAGSLAFGASCLVTGLAFGALALCAAQLAEHSRSAGGLAMAVLGALFLARAVGDVDDPDGGSWLSWLSPIAWAQQIRAFADLRWWPLGLGLGLAVLALVVAWLLAGRRDLGEGLLPARRGRASAPAGLVSPAGMALRLLRPSIIAWTIALLVLGVVFGSLAGAIEDLVAETPEIATWLGGSGALLDSFGGLIAAYLAAGVTALAVHLVLRLREEESAGRIEHQIAMGAGRIGVMGGWLAVSAVGVTLALLASAVGLGIGTASALDDRAWLWRLIGATLGYLPAVLAVLGLAVALVGWAPRAAKAAWILVGWIAVVVFFEDLLGIPDAVADISPVALTPTAPAEDASVMVLICLTAAAAVLSGIGLWGMRRRDLTGA
>NZ_CP019400.1|WP_015069351.1|2908162_2909149_+|ABC-transporter-ATP-binding-protein
MNDAPIDCRGLEKSFGRTRALNGFDLRVEPGEIAGFLGPNGAGKSTTIRILLGVLRADGGTARVLGADPWADAVALHRRMAYVPGDVSLWPGISGGEIIDYLVGLRSTAYRRSDQYRRRRRDLLERFQLDPTKKAGTYSKGNRQKVALVAALSCDADLYLFDEPTSGLDPLMEALFTAELARLRDEGRTVLLSSHILGEVENACDTVTIIRDGRAAESGRLDELRHLRRAGVEAVLSGEAADRLGALDGVHDVSRDGERMAFTVDDAAMTQVLGTLADVDAREVSIQPVRLERLFLDHYESSSDRDIPGEDGEGRHAEGKTDARGTRR
>NZ_CP019400.1|WP_081583319.1|2907399_2908170_+|TetR/AcrR-family-transcriptional-regulator
MDSTNESGDRAPSGPGRKAGGTRGGARAQVAEETRARILDAAFGVFAEQGFAAPLRAVADRAGVSAALIVHYFGSHDGLRRACDERFDELTTELKTDVLDPVAGPAEARRQSDDIAHYAPMIGYLIRVLRAGDAASIRFVDRMSEAAEQYLARGVEAGMIRPTGDEPARARTLVAMSLGAVMLGFPTLDGRIDLETLPERLDEYRGRSLVPMLEIATYGYLTDSRILDALTHDDTTDHEPTDDDITHHNAEADGHE
>NZ_CP019400.1|WP_015069348.1|2905865_2907239_-|APC-family-permease
MAKDNAAAQAPETREDSGLRRSLTLRDLIVYGLLFIGPTAPMGTFGVLDARSGGAIGLVFVVATLAMAFTAWSYARMSRAVPLAGSVFAYASAGLGRRPGFIAGWMIGLDYLFIPSMASLFTGIAAHQLIPAVPVWVFTLIGILIITGLNLAGVKTAAIVGFVMLAIEVAVLAVFVVAAAVVLARHGAQRPWLSPLTGLDGFDLAGILGAVSVAVLAFLGFDAIASFAEETTGSNRQVSRALQFCLALAGALFVVQTYLGALLSPLTPAYLNAHQGEQGTAFYQLLDTQIGTWFGTTVTLIKAVGPVFSALVAQAAVSRLMFGMARDGALPKALATVDPRTRTPRTAVLVSAVFTILIAIAAAVREDGLEVLSSMVTVGALVGFLFLHAAVIGYYVRGRRTEQRTRHIVVPVVGAVIIAIVLALAAHLALAIAAVWLVIGVVVLVIRESRRKEPERS
>NZ_CP019400.1|WP_015069359.1|2918023_2918644_+|recombination-protein-RecR
MYDGPLQDLIDALSRLPGIGPKGAQRIAFHILDASQEEVDALADTLREVKEKAKFCSVCFNVSADETCRYCRDSRRDQSVICVVEESKDVIAVERTREFRGLYHVLGGAISPLDGKGPADLHIRELCTRLADGVVTEVILATNPNLEGEATASYLSRLLTPMGVKVSRLASGLPVGGDLEYADEVTLGRAFEGRRYVSAEPDARTA
>NZ_CP019400.1|WP_015069360.1|2918702_2919017_+|thiamine-binding-protein
MIAAFSLVPSGGRASREDGGVAEAVAAAVRVIRESGLPNRTNSMFTEIEGSWDECMDVVKKATEAVAEYGTRVSLVLKADIRPGRTGEMTGKLERLEAEISKQA
>NZ_CP019400.1|WP_015069361.1|2919053_2920277_-|MFS-transporter
MTSAASATRFAPPRQAVRARMGTLMLFATNGLTFASLIPRYPEIKADLGASQTLWGLAVGIGPIGGLALGLATARLMSRFGSRNVAAWPQILSTAGLLLMANAPHVGWVFVAMIAMSAFDAVTDTAMNYQALRVQEMYKRSIINTFHGWWSVGAVLGGFIGSAMAQWRVDINLQASLTMVVLALVCALSWSLMLPGRDTGTDRSTSDGDQRRARVPATTWLHIIGLGLLGALAGGIEIGGSTWAPLYMDAQFNSTPFIAGMGFTILMVAETAGRLIGDLIVNRFGQAFAVAQGSVICLVGMAVAIAWPTTASTLIGFAAAGWGVATIIPLAMNVADSLPGVRSGAGLTIATWVMRLGFMLFPIGIGALGDAVALRWAMICLPAGALVMLALVPLVGAGRRRRAPEAV
>NZ_CP019400.1|WP_015069362.1|2920421_2922254_-|beta-galactosidase
MAENAALIRADGALLRVTDDGALTRAGAPHRIMSGSMHYFRVHPGQWRDRLRRLVDMGLNTLDTYVAWNFHQPQEGRPATFDGWCDVERFIGMAGEEGLDVIVRPGPYICAEWSNGGLPSWLTRRTASENGVGRRPLVPRSSDPGFTRRVARWFDDLIPRIAALQACHGGPVVAVQVENEYGSYGDDAAYLTWLRTALVERGVTELLFTADGPTELMLDGGTLDGTLAAVTLGSGARAARELQQSRRPGEPFLAAEFWDGWFDHWGEKHHVRSADSATAALSEILDAGSVSIYMAHGGTNFGLWAGSNEDNGKIQPTVTSYDSDAPIAEDGRLTPKFHAFRELLGATGPLLSTEPRFLPETSVPLTPAAGLLPGLMANGIPTPRTPAPASFEQLRLDAGISVHRARPVLPHGPVTLRITDLADRAVVFVDGERVGALEGPGQITVEGHGRRVDLLLIVEAYGRINYGPLLGAPKGLLGPVMVERRMIHGWWNRAVPLQDWGDLELARAMAAGDDVNNEGTGFATASWSVEEPADTHLMLPGSGRGYCWINGFLLGRYDERGPQCSLYCPAPLLHPGSNTVTVLETEHLGDSVEMRQHPDLGPTEEYIEQF
>NZ_CP019400.1|WP_015069363.1|2922408_2923035_+|PadR-family-transcriptional-regulator
MSIRFAILALLDERASYGYEIKAEFDRRTNRTWPLNIGQVYTTLDRLERDQLVSRGSENAEGRVMYEITPGGSRAVSDWFASVIPDYPQRDELAIKIAMAATRPGCDVGAIIQNQRRESMRALQNHHQALRGIDEEDLAGELVIQSLIYSSEAQIRWLDHCETAALRASRSASRGAGGPGGAGTPRATGADAAAPAGKRATRITRDAR
>NZ_CP019400.1|WP_015069364.1|2923031_2923811_+|ABC-transporter-ATP-binding-protein
MTAPVRAADRPEAPAGRTVLSLDHVSRTFEAGSQPVHALSDVCIGVDPGAFISVMGPSGSGKSTLLALAGGLDQPTAGAVSVCGQPLAGLSRDDLARIRRRQLGFVFQDFNLVSTLTALENVALPLELDGVGARQARTVAEEALDRVGLPELGDRFIEEMSGGQQQRVAIGRAIVGDRRLLLADEPTGALDSATGDEIMALIRKLADEGVAVVLVTHEARHAAWADRVVFLRDGRLVDESESESDPMSLLAEGPRRGSW
>NZ_CP019400.1|WP_028701398.1|2923810_2926552_+|FtsX-like-permease-family-protein
MHRRALPAGRPGAAQGRGRASRRLVVRLARRDIARHRARAVLVMVLVALPVAMICGLAVIWNLTGSTVDDYVEQQFGDADVIVAPLSDWDGHCRQISLGDGSCADGSKKLSAADAARKKATLATVRIPGDTLHPVRTKGVTAHWKGLDVDAQVTGADQLRLRTQQISLPKGATAMPGAHEIWINAEAAHRYGWDVGATVQVSGATYRVTGLVRAASWPAVQIWVGPDHPLAAGGDLTWYGTGPTPSSVRVKGLNDEGLGVMDRAGYRTVQMAGTATEETTRIAVAFAIGALAALVTATIAGAAFAVGARQQRRGLALLGATGADRRVLVRLVRSQGVLLGLGGALAGAALGTALGEGFVAWRNARTLNFPQPLAIPWAPLAGAVVLGVAAATVAAWVPAHAVARQDVLAGVRSAETASRPARFPWVGLGLIVVGIAVGTWAVVGYHRSHPSPDDVSGTEQLMIPLVIGIVALFVGAVASLSWMLSRIARPGFRGPLALRFALRDLARNRGRGVACVAASMAVMTLFSAVLVLMATQDRTDVAAYRPSLPTGVGVLKGSDDSMHPIDDRAADQQLAAVRAEVGVSGEPVRESAVMRCAASGNSDQHIGDTGRRYCEEAMTIMVRTSAVAGAGATDPDAEGSFSFDSQHLMVDDGSLYRVLTGRAPDQRVEAALSRGVVVFDRHFAPRGTTAVVAERSTSAEDLAITRTVVPATVVPGTPGSGVPALIGRDAAARLMGVAPGRLNLAGGRTWMRLQDTPTQAQSDRINASIARATSLQQGFSYETGPSRTALAYLRWGAGLAAVLALTVAVVVLALSLSDSRASRSALASVGASSGSLRGIAAVQALVTVGLGSVLGALVGAAPMALAIWGAGPSMTLAIPWGYLVALALGVPALTGLAVRALVPAARPMLRRRD
>NZ_CP019400.1|WP_154662072.1|2926426_2928085_-|threonine/serine-exporter-family-protein
MSGTQGGTPSRSRRLWRVPLERYLRDARPLPPSRDLESVCEDEMAAAQAREVFDLIMRVTVVAVSVGASSAEAIAMGLRIADAYGINVHIDITNSSVIVTQHRSLDDDPITALRVVRTRTADYQRLGRLEQLVADVSARRIEPAPARERLNDLMTAPRLYKKWFVTVNMGVMGAAMAALYGASVLDVVIAFAAICLVDIAVQGLARRRVASFFVQAVGGAIPTAVALVLMLLRTATGMRLDLSPSLVVAAGMISLLAGTGAVAAAQDALDGYYVTSAGRFLEVLLQTGGIIFGVMTTLWIGLKLGVPGYISPQLVWTSAPWVQIVASVIASIAFGATAHSGPRTLGVCGILGGLGWSEYLVGMWLTDSMVIASGIGAVAIGLVSAAAAKRWRVPQVALVTISVVPLMPGMMLYRGLYMTMAGQLGIPAPGTGVTVLAQSLLIGVALAAGSSLGALAARPFAIPSDHRTRRAVMASWFRGSAVPRDWVPRRHRRRTPRPVPTAEPDGPEATASVPAPQHRTGGGDERPHGEAREGRDAQCQSDQVSPGDREGH
>NZ_CP019400.1|WP_015069367.1|2928241_2929045_+|HAD-family-phosphatase
MLIATDLDGTLVRSDNTISPRALKAIAAAEEAGVPVVPVTGRQFGGLRDILGAFSRYALVNNGSMGVDLADGQRTMFCETTPAATVAAFVDAVREYSPKASFAAVREEGRVFAHTDGYLELTRPDELIKDPAEYRRVEVAEIGTQDCLKLMVRSAEMPLEEFVARTLGLGVAGAHTSWSGFPMVEMCADGLTKATGLDRLTRLLGMTRADVVALGDGGNDVEMLGWAGRSFAMADGQQVARDAATDVAPPADEDGFAQVVESLLETL
>NZ_CP019400.1|WP_028701396.1|2929044_2929863_+|HAD-family-phosphatase
MFIATDLDGTLLTPSGTISARSAAAIAAAEEAGVPVVPVTARQLYGLDDLRSRLGRWALCSNGAVCWDLHAETVLFHLETSAEVASTFARELLAVEPRTRFASIQRDGAFFASQAGYADLCVFTDHHRDPADMPRLGIEEVVGAPTLKLVARHPSLSVQELAAVARRLPSASAVHITSSGAGMLEISAAGVTKSAGLQVFADHLGMTGADAVAFGDGENDVEMLRWAGRSWAVANAVPAALEAAGKIAGSNAEDGVAQVIEELLEQRNATVA

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Crispr_ID: NZ_CP019400_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_12

2950287-2950421

Orphan

Consensus_repeat	Method
GGCGGCCTTGCGTTCGGCCGCGGCCTTGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_12

>merge|NZ_CP019400|12|2950287-2950421|CRISPRCasFinder
GGCGGCCTTCTGGGCGGCGGCGGCCTTGGCGGCGCGTTCCTGGGCGGCCTTGCGTTCGGCCGCGGCCTTGGCTTTGGCGGCGGCGATCTTGGCGGCGCGCTCCTCGGCGGCCTTGCGTTCGGCCTCGGCCTTGGC

>NZ_CP019400|12|12|2950287-2950421|CRISPRCasFinder
GGCGGCCTTCTGGGCGGCGGCGGCCTTGGC	GGCGCGTTCCTGGGCGGCCTTGCGTTCGGCCGCGGCCTTGGCTTTGGCGGCGGCGATCTTGGCGGCGCGCTCCTC
GGCGGCCTTGCGTTCGGCCTCGGCCTTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_071162004.1\|2942516_2943545_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP019400.1\|WP_028700348.1\|2953521_2954610_-\|cutinase-family-protein	unknown	unknown	gnl\|CDD\|366455
NZ_CP019400.1\|WP_028700347.1\|2955426_2955951_-\|2'-5'-RNA-ligase	unknown	unknown	gnl\|CDD\|379265
NZ_CP019400.1\|WP_015069390.1\|2954771_2955233_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_CP019400.1\|WP_028700355.1\|2943626_2944877_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP019400.1\|WP_028700345.1\|2958990_2959647_+\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|188632
NZ_CP019400.1\|WP_051281546.1\|2961782_2962454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225500
NZ_CP019400.1\|WP_028700354.1\|2944962_2945847_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP019400.1\|WP_028700353.1\|2946355_2947651_-\|transporter	unknown	unknown	gnl\|CDD\|238538
NZ_CP019400.1\|WP_036935936.1\|2964075_2965413_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340895
NZ_CP019400.1\|WP_028700346.1\|2956117_2958712_-\|DUF3516-domain-containing-protein	unknown	unknown	gnl\|CDD\|378795
NZ_CP019400.1\|WP_028700344.1\|2959737_2961420_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
NZ_CP019400.1\|WP_015069383.1\|2948555_2948972_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP019400.1\|WP_051143471.1\|2940743_2942381_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200578
NZ_CP019400.1\|WP_015069384.1\|2948968_2949328_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP019400.1\|WP_028700349.1\|2952797_2953511_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_138575414.1\|2939397_2940603_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP019400.1\|WP_028700350.1\|2951523_2952384_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NZ_CP019400.1\|WP_051281547.1\|2945843_2946353_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP019400.1\|WP_028700352.1\|2947944_2948502_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_071162004.1\|2942516_2943545_-\|TerC-family-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	3.57575e-131
NZ_CP019400.1\|WP_028700348.1\|2953521_2954610_-\|cutinase-family-protein	gnl\|CDD\|366455	pfam01083, Cutinase, Cutinase.	4.70635e-12
NZ_CP019400.1\|WP_028700347.1\|2955426_2955951_-\|2'-5'-RNA-ligase	gnl\|CDD\|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	8.37177e-05
NZ_CP019400.1\|WP_015069390.1\|2954771_2955233_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	5.03587e-54
NZ_CP019400.1\|WP_028700355.1\|2943626_2944877_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.33434e-59
NZ_CP019400.1\|WP_028700345.1\|2958990_2959647_+\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl\|CDD\|188632	cd00452, KDPG_aldolase, KDPG and KHG aldolase. KDPG and KHG aldolase. This family belongs to the class I adolases whose reaction mechanism involves Schiff base formation between a substrate carbonyl and lysine residue in the active site. 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, is best known for its role in the Entner-Doudoroff pathway of bacteria, where it catalyzes the reversible cleavage of KDPG to pyruvate and glyceraldehyde-3-phosphate. 2-keto-4-hydroxyglutarate (KHG) aldolase, which has enzymatic specificity toward glyoxylate, forming KHG in the presence of pyruvate, and is capable of regulating glyoxylate levels in the glyoxylate bypass, an alternate pathway when bacteria are grown on acetate carbon sources.	2.03822e-26
NZ_CP019400.1\|WP_051281546.1\|2961782_2962454_+\|hypothetical-protein	gnl\|CDD\|225500	COG2949, SanA, Uncharacterized membrane protein [Function unknown].	4.85742e-45
NZ_CP019400.1\|WP_028700354.1\|2944962_2945847_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.57908e-58
NZ_CP019400.1\|WP_028700353.1\|2946355_2947651_-\|transporter	gnl\|CDD\|238538	cd01118, ArsB_permease, Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.	7.71721e-85
NZ_CP019400.1\|WP_036935936.1\|2964075_2965413_+\|MFS-transporter	gnl\|CDD\|340895	cd17337, MFS_CsbX, CsbX family of the Major Facilitator Superfamily of transporters. The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.10869e-166
NZ_CP019400.1\|WP_028700346.1\|2956117_2958712_-\|DUF3516-domain-containing-protein	gnl\|CDD\|378795	pfam12029, DUF3516, Domain of unknown function (DUF3516). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with pfam00270, pfam00271.	0
NZ_CP019400.1\|WP_028700344.1\|2959737_2961420_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP019400.1\|WP_015069383.1\|2948555_2948972_+\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	3.54734e-23
NZ_CP019400.1\|WP_051143471.1\|2940743_2942381_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200578	cd10954, CE4_CtAXE_like, Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs. This family is represented by Clostridium thermocellum acetylxylan esterase (CtAXE, EC 3.1.1.72), a member of the carbohydrate esterase 4 (CE4) superfamily. CtAXE deacetylates O-acetylated xylan, a key component of plant cell walls. It shows no detectable activity on generic esterase substrates including para-nitrophenyl acetate. It is specific for sugar-based substrates and will precipitate acetylxylan, as a consequence of deacetylation. CtAXE is a monomeric protein containing a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold as other CE4 esterases. However, due to differences in the topography of the substrate-binding groove, the chemistry of the active center, and metal ion coordination, CtAXE has different metal ion preference and lacks activity on N-acetyl substrates. It is significantly activated by Co2+. Moreover, CtAXE displays distinctly different ligand coordination to the metal ion, utilizing an aspartate, a histidine, and four water molecules, as opposed to the conserved His-His-Asp zinc-binding triad of other CE4 esterases.	5.06861e-61
NZ_CP019400.1\|WP_015069384.1\|2948968_2949328_+\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	8.79836e-21
NZ_CP019400.1\|WP_138575414.1\|2939397_2940603_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.60342e-09
NZ_CP019400.1\|WP_028700350.1\|2951523_2952384_-\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	1.67163e-87
NZ_CP019400.1\|WP_051281547.1\|2945843_2946353_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	0.000488526
NZ_CP019400.1\|WP_028700352.1\|2947944_2948502_+\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.1434e-08

>NZ_CP019400.1|WP_015069384.1|2948968_2949328_+|CrcB-family-protein
MTWLFVSLAGGAGAATRFLVDSWIARHNRLNTPMGTIVINVTACFILGLATGLGLDHTMTASWTSVIGTGFCGGYSTFSTASVEGARLFLSGRARAGLLHAGGMLVLGTAAAALGMLLG
>NZ_CP019400.1|WP_015069383.1|2948555_2948972_+|CrcB-family-protein
MWALALLVGVGGCVGTLVRALLESAFGADHGHFPVMTLTINLVGSVVLGLLLEGLARTGDDVGPRKAVRLGVGTGVIGGFTTYSTFAVETDRLLGGGSPVIGLVYALVSVAAGLLCAASGILVARKVFRARPMDGEGR
>NZ_CP019400.1|WP_028700352.1|2947944_2948502_+|universal-stress-protein
MAERSVPQPGLERLVDFRSGPVIAGFSPGQHPLVAVTAARLAEALGGGTVHLAFVDTNRYAVEEFGDGTVRHAPIDPDAEAHDWRRTREELEQQAAATFDGAGMTVEWRLWYLAGRPDRALTHLARALDASVFVVGSRSSRPGRRIRELAEGSVSNHLAHHQHRPVLTVPIEVVDWKDAGTPWRP
>NZ_CP019400.1|WP_028700353.1|2946355_2947651_-|transporter
MNTWAAEAIAAAVLLLVLVFAVIRPKNLPEALPAVPGALLLCLIGAISWSEAWSQVARMLPTVLFLAGVLMLAHLCQAEGMFDAAGRLMARGSHGSPVRLLGLVFVVASVTTALLSLDATIVLLTPVIFTTAARVGARPKPFIYGTAHLSNSASLLLPVSNLTNLLALSAAGISFPRFAALMVGPWLVAIGVEYVAHRRYFATELSVSSGYPASSGTIPGTDDAGQPAPVFSLVVLGLTLAGFVVLSVLGAEPFWAALVGVVVIGGKRLIRGDGSRRDELKELGAAANPFFLLFVLSLSIIVAAVVDHGVAAAMRTVVPGDQSLLSLLILVLIAALLANLVNNLPAVLVMLPLVAPVGPVAVLAVLIGVNVGPNLTYVGSLATLLWRRIVAAHDHRTSTGEFTRLGLITVPICLVLCTMALSAAASLMGVS
>NZ_CP019400.1|WP_051281547.1|2945843_2946353_-|universal-stress-protein
MRVLAWIAPATWPAVVDALLERHGDDEITLVAAADAYADFPPGRLGGLLGRRPPKAGPKESELASEMARDLLHQASERLRGDAWATVLIGPTERVITEAAADADHLVMARDGDRSRLGPPSLGDHSRFVIDHAPCTVELVWPGKAPGLATIPPPPDDARQRQPRGRSNA
>NZ_CP019400.1|WP_028700354.1|2944962_2945847_+|LysR-family-transcriptional-regulator
MLSDDLSWFLILAESEHIGDAAAELRMPQSTLSRRLGRLEQRLGTTLFDRHGRSLTLNTRGAALRRRLRAAVIQLDLAESEVLRLLDPETGLVRFDFMHSFGTWLAPRLIHGFVDDHPRADIHLHQGIGRDLIARVRDDEADVALCSPRPEGEDLGWLEVLRQPMAACLPSDHRLAHRRRIRLADIASEPFISTPAGFNSRDLLEGIAADEGVDIHVAFESDELSTVAGLVVSGVGVALLPADDPYLQLPGAVFIPLTTRRTREVGLIWRADQDPASTPGLFLDSARRVLSLMS
>NZ_CP019400.1|WP_028700355.1|2943626_2944877_-|MFS-transporter
MTTITSPATLLVPTPHSSSPDTLPEGLSQGEPGYRRASLALLAAGLASFNALYCTQALMPTLTSQLGATPAQASLTVSAATGILAITILPVSVLSERFGRGRLMTISAMAAVVVGLLLPLAPSLGWLVVGRGLQGLLVAGVPATAMAWLSQEIHPRHLPRAMGLYVAGNTVGGLLGRLIPSGVLQFTGWRPALGIDMAFALVCTVAMVTLMPAERRFVPKQLRPGNELRTMGRQWADRRLAGLFGIGFIFMGVFVSLYDFLGYRLTARFGMPPSLIGLVFLLYLFGTLASARAGHLTATRGRGPAMLIGAAMAIVGMPLVASGLLWLTLPGVALFTYGFFTVHSVASGWVGALAPRARGEASGTYLACYYLGSSILGYLSGHVMHAFGWTGLVMWLVGLILIGCALSAMVVRSARS
>NZ_CP019400.1|WP_071162004.1|2942516_2943545_-|TerC-family-protein
MVWTLTIVGLLALLAVDFMTHVRKAHAPTLKEAAIWSAVFVGVALAFGAGVWLTGGAELGKEYFAGYVTEKALSVDNLFLFLVIMTSFAVPRANQQKVLMFGVIFSLIARTGLILAGAALVNSFSWVFYIFGIILLFTAGSMVKGHGKEEDPEAGDNVMVRLARRFIHSTDYYDGDRMTTIHEGRRAMTPMMLVMVAIAGTDVLFAVDSIPAIFGLTQNAYIVFTATAFSLLGLRQLYFLLDGLLDRLVHLSIGLSVILGFIGVKLILHALHENQIPFINGGQPLHVPEVSTDLSLLVILGVLTVTVITSLISTRRAEKREAVDAESSGEPADEPQSVNSPS
>NZ_CP019400.1|WP_051143471.1|2940743_2942381_-|polysaccharide-deacetylase-family-protein
MNLTRRGFIGASSGLLAALSLSACNGSDDRPGSSGAGNKGSKGTPAPASMTKVDAALVSGAIPTKLTASNPRTVSAAVPQIPKARNLTQALEVVRERTLRQAAWDKASAVDISTSYVAASADVIGVLVKATTTKAGKETTALTSLWYNAQLSQTFSPSVLISWPGWADFAKAVGKAASDASLDKAKVLKALQDTPAPYGTGPAIAFDTAGGVVVNFPPGAVKAEPTEVRVPKKTVTPLLSDFGVLAEGASNHPSAFSGTPTTTLTWWKPGQNKPRPSGSPNLRPLPGDSTGPVTTQSAAPSASASPSASPSPSAGASGPEHPSTAIGIDCVANKAVALTYDDGPGPETATVLAALEKHKGAATFFEMGNSIDAYPKTTVLVAASGYEIGSHTVTHPDLATLGSERLKQEITGNSARIKKLIGRSPLLLRPPYGSHNEAADEVASADGMAIVNWSVDTEDWKTKSTSATEQKVFNDVKIYTEPIILMHDIHDFTVAAAGPIIEKLTAEGYKLVTVSEMTLNTGGFRTGHGYCRGTSLVQDGYLCKG
>NZ_CP019400.1|WP_138575414.1|2939397_2940603_+|DDE-type-integrase/transposase/recombinase
MSMAARREITKKYAHQYRAASKKDKSVLLDSLTATTGWTRDHARRAIRAALTRKGAASQQKRRPRPRKYSYDAVKVLQHVWSVTGQPSGKYLAPVMDDTLNRLERFKEFGKVTRRATPAVLTELRSMSAATIDRYLKPFKDAAYPAAGLSATRPAPHILRAAVPLRTSLDGPITDPGLVEVDTVAHCGHTLVGEFLWTLSATLPVSGYTVLTTVKNKAFVHIGAGMDRIVDQMPVPVAEVHVDNGSEFINWGLIDWAKGHDIAMSRSRPYKKNDNAHVEQRNGDWVRRHAFRYRYETATELQLLNQLWPLVMARKNHLLPCVKAIGWTTTSAGRKKRVYDKPKTPYQRLVDSGVLDPATRARLAAEHDRLNPADLARRITDIQNQLIRLAERRTQTDQPAA
>NZ_CP019400.1|WP_028700350.1|2951523_2952384_-|aldo/keto-reductase
MKYRNLGPYKASAISYGNMPLSIEGRPDRATAIDVIHAALDAGVTHIDTAWAYYPSGEEPQYGEGLAAEALRTWDGDRSAISIATKVGHYRNFTDGKPTWAVDDEPEHLKERAHESARALGVETIDLLYSHRPSPDVPYEKVIGALADLLDEGLTRTVGISNVNPDQIRLAHRILGDRLVAVQNQFSPGFRSSEPEIDVTGELGLAFVAWSPLGGYRKPLDEPKFAPFQKIADARGISRAQVILAWELARAPHVIPIPGSHRTATILDSLKAADLELTDAELASLG
>NZ_CP019400.1|WP_028700349.1|2952797_2953511_+|hypothetical-protein
MIQLLIGALALGIAGFDPLGSVVLVAALGMGTGRRGVLSLGVTGVLTSEVLGLAGALGLTALARDAGVHPPHVPHPVWLVAVTLVGAGLAVWALFYGRRRSGAEDPGVDRSGSAGRARPRSASAPALALSGLVVGLSSLADPAFWAMVVHAARWSRASWAALEASIWVVCSHSLLIVLVICYLAVGPQQVNRLVDQVMGRHAVAVRRTVAIIAGLAGVLLLVDVGVAVATGAWLFAL
>NZ_CP019400.1|WP_028700348.1|2953521_2954610_-|cutinase-family-protein
MGWKADPVASGKASTQPCASVLFVGVRGSGEEEPYGRTITGVRDGLAARWEGRGSVRQVWLDYPAVDPHTLQNESLTRLLFDEKMPSTKYFDSAATGASRLVSLLREQGRRCPSEWVVLAGYSQGAQAITSALSQTDVSARLAGAILAGNPSHYPGQNVQELSGSAPLTSIGLASLLYDLRARAARVEGSRDDQVKELIQATIDLHNDDQNLAELRSAMKREKAVVPASAYPATYSICQEGDPVCDAAPAMTRILTIQSTWEQELRKASSAHAVYTPEVLKTSLNATANRMNAVARADAKGNPVPRGQQVDVTVNRWGPAQIGVAVAAGVAGLLIGLGAATLRGRRRRAVSGRAASKRSKRH
>NZ_CP019400.1|WP_015069390.1|2954771_2955233_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MELTSTSIADGQPIDSRYAHPNVGGRNVIPQLSWTQGPVGTHSYAITIYDPDAPTGSGFWHWILADIPADVTEIPEGGPLPEGVRQWVNDAQEEGYSGPFPPPGPSHRYIHTVHAMPAEHLPAADEAANVQVRFAIHTSELAEASLTGTYQVD
>NZ_CP019400.1|WP_028700347.1|2955426_2955951_-|2'-5'-RNA-ligase
MSLSVCLLFDRRTDRALRGLWGRLESIGVSTLLTHTHEKHLPHLSYAVLRNWEIDRVVEAVASLPAGDPIPLHFDTVGHFHRGRAALIAAPRADLLARQQRVVDALTSTGADLHHYYLPGRWVPHTSLATHVKAAQLAAMTSLAHDVLPLDATAVGASIIDSGTGLRHDLAMIP
>NZ_CP019400.1|WP_028700346.1|2956117_2958712_-|DUF3516-domain-containing-protein
MRLAEALDDMLDARPPVETDRGERPAGWDSPGARPIDPDMALDHIERAVSRDGLTMYDHQEEAILEILTGSHVIVTTPTGSGKSLIAAAAHFACVAGGGRSYYTAPIKALVSEKFFDLCAIFGAARVGMVTGDASVNADAPIICCTAEILANIALREGRHAAVDQVVMDEFHFIGDPDRGWAWQVPLSELPQAQQIIMSATLGDVSQLAEDLTAGTGRPTTVITGVTRPVPLLYEWSMESDHDTVEQLVEEQKAPVYIVHPSQKAALERAQSLTSMKLVSTEERHGIAAEIADFRFSKGFGSTVRKFITSGIGVHHAGMLPKYRRLVETLAQQGRLKVICGTDTLGVGINVPIRTVMFIALTKFDGRRMRVLKSREFHQIAGRAGRAGFDSVGYVVAEAPEHVVANAKAAAKAGDDPKKQRRIKKQKAPEGFINFDEETFKKLIASTPETLHARMRITDAMLLNLLSRDEDTVAAVKHLVDAATSSAAERKRLYRRAIQLGRALLHSGVVHRLDEPTPGGRRYAMNEDLQEDFALNQPLSAFAAEAIETLDPDSATHALDVVSVIEATLDNPMTLLYAQQRLARGEAIGELKAEGYDYEDRMAAVEDVEWPRPLGETLDALFEIFAPSHPWVPADALSPKSIVRDMYERAMTFGEFCAFYKVQRSEGLVLRYLTDAYRALRQTVPEAERTEELSDLISWLGEVIRTTDSSLIDEWEALTHPEESDEPEEVRPVHTFTSNQRAFRVALRNAMFRKVILAADDDFEGLAALEPDGSPMKARDWEDALGSYWDEHEEINDGPDARSPAMLVIENEFGRRDSRIRLVRQIIDDPEGNHDWSITATVDLDECDEADDLILRTRAFSRLD
>NZ_CP019400.1|WP_028700345.1|2958990_2959647_+|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MSSQPAPESGRLPLPARMLSSQVVAVLPDEPVDSMMAPVEVMLQEGIQVFSLPAGAVERLTTLHTIFGARGSFGVHGVIDPDGIDALIATGIEFALPVGPTPQVLAALRAAGVPAVPDALTPTEVRAVWAAGADAVQVVPADIGSATYGPALVELAPGVPCLPRGGVGSYALRKWISSGAPAACLDEILVGDACTDSALPALRERCRSVLAVIADERA
>NZ_CP019400.1|WP_028700344.1|2959737_2961420_+|glucose-6-phosphate-isomerase
MTTPVDATSTPAWDKLAQLQPTIVDGPHVLRRWFDADPGRAQRYTFEAADLHVDLSKNLLTDEVRDALLELADQVRIPARRDAMYSGEHINVTEDRAVLHTALRRPATDSLTVDGQDVVADVHEVLERVYDFARKVRSGQWKGVTGKPIRTVVNIGIGGSDLGPVMAYEALKPYVQEGLEARFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRSWLLDGLVAAGAVEDTEEARNAAVAKHFVAVSTALDRVAAFGIDPDNAFGFWSWVGGRYSVDSAVGTVLAVAIGPEGFADFLSGFHAIDEHFATAAPEKNVPLLMGLLNIWYVNFWNAHSHAVLPYSQYMHRFPAYLQQLTMESNGKSVRWDGTPVTSQTGEIFWGEPGTNGQHAFYQLIHQGTRVIPADFIAVANPAHPTKDGDTDVHELFLSNFFAQTAALAFGKTAAEVEAEGTPASIVPARVFSGDRPTTSIMADELSPKVLGELIALYEHITFVEGVVWGIDSFDQWGVELGKKLALEIAPAVSGDDAALASQDSSTQGLVSWYRAHRS
>NZ_CP019400.1|WP_051281546.1|2961782_2962454_+|hypothetical-protein
MATRGRFRWLRRGIIGTVGLAILVLGGPWALAEGLSLGKVGPAAQAPARDVAIVFGAAVLPDGTPSNYLRGRLDVAADLYERGAVRAILVSGDNSTQYYNEPDNMKRYLVDSRGIPTEKVVTDYAGFDTYDTCVRARRIFGITSATLVTQDYHLTRAVATCRMTGGMNVVGAPDTSRAHDRTWWYGWSREFGARLKMLYDVVTHRTPTLGAQETGIRDALGKR
>NZ_CP019400.1|WP_036935936.1|2964075_2965413_+|MFS-transporter
MSTQSGGPAEGLLERQGIAKHLLWGFVAVILFQTGNGLELSFYSGFLQSAKGLSSGQVATMTMAYGIVIAIASWFSGSLADAWGPRRVMMMGFGAWLIFELVFLWGGVTTGSYAVMVIGYALRGFGYPLFCYGFLAWVTMDTPEEHLGRGVGWFWFAQALGMGALSGFIAGPLIGAIGEMATLWTSFAFVVVGGLLAILLVRRPKELQTAAESGSTPSASETISGLVRGVTILKDYPKTAVGGVVRIINQAAFYGIPVFFAPYMTGDVGFSSAQWATIWGTLNLANVFANLVFGYIGDAFGRVRTVAWFGGLGCGIAVFLMWWFPSMWGANFAAEMIAGILFGIGLAAYVPLSAIMPLLVAPDRKGSAVAILNLGAGLSNFAGPALAPLAGPIGIGGLMIVYAALHVVGGGLTYALKPSKGNGNEPGAGTGTPESTPASPEPVSQ

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Crispr_ID: NZ_CP019400_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_13

3065334-3065420

Orphan

Consensus_repeat	Method
GTGAGGTCCGGGACACGGTGGGACGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_13

>merge|NZ_CP019400|13|3065334-3065420|CRISPRCasFinder
GTGAGGTCCGGGACACGGTGGGACGGACCTCCTCTCCCGGCTCATCGTGGTCCTGCGACCTGTGAGGTCCGGGACTCGGTGGGACGG

>NZ_CP019400|13|13|3065334-3065420|CRISPRCasFinder
GTGAGGTCCGGGACACGGTGGGACGG	ACCTCCTCTCCCGGCTCATCGTGGTCCTGCGACCT
GTGAGGTCCGGGACTCGGTGGGACGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_015069490.1\|3059249_3060599_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP019400.1\|WP_051281536.1\|3052310_3053216_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP019400.1\|WP_015069494.1\|3064291_3065224_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|225408
NZ_CP019400.1\|WP_015069493.1\|3062652_3064002_+\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|133432
NZ_CP019400.1\|WP_015069502.1\|3071809_3071926_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NZ_CP019400.1\|WP_154662003.1\|3072053_3074630_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_027588481.1\|3075012_3078171_-\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NZ_CP019400.1\|WP_138575432.1\|3058277_3059120_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP019400.1\|WP_076692615.1\|3078171_3079275_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341156
NZ_CP019400.1\|WP_015069491.1\|3060663_3061761_-\|PfkB-domain-containing-protein	unknown	unknown	gnl\|CDD\|238917
NZ_CP019400.1\|WP_015069498.1\|3069350_3070058_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP019400.1\|WP_015069488.1\|3057480_3058278_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP019400.1\|WP_015069487.1\|3054765_3057363_+\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP019400.1\|WP_015069492.1\|3061894_3062656_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP019400.1\|WP_015069499.1\|3070289_3071156_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP019400.1\|WP_015069496.1\|3066322_3068497_-\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP019400.1\|WP_051143621.1\|3068493_3069303_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|365804
NZ_CP019400.1\|WP_015069495.1\|3065640_3066177_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NZ_CP019400.1\|WP_015069486.1\|3053248_3054631_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NZ_CP019400.1\|WP_095532344.1\|3071306_3071570_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015069490.1\|3059249_3060599_-\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.48996e-64
NZ_CP019400.1\|WP_051281536.1\|3052310_3053216_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.46742e-85
NZ_CP019400.1\|WP_015069494.1\|3064291_3065224_+\|DUF559-domain-containing-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.000101626
NZ_CP019400.1\|WP_015069493.1\|3062652_3064002_+\|glycoside-hydrolase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	5.59186e-174
NZ_CP019400.1\|WP_027588481.1\|3075012_3078171_-\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	1.04865e-154
NZ_CP019400.1\|WP_138575432.1\|3058277_3059120_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	8.36654e-72
NZ_CP019400.1\|WP_076692615.1\|3078171_3079275_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341156	cd17267, RMtype1_S_EcoAO83I-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.EcoAO83I TRD1-CR1 and S.AbaB8342I TRD2-CR2. Escherichia coli strain A0 34/86 S subunit (S.EcoAO83I) recognizes 5'... GGANNNNNNNNATGC ... 3, and Acinetobacter baumannii B8342 S subunit (S.AbaB8342I) recognizes 5'... TTCANNNNNNTCC ... 3. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example S.AbaB8342I-TRD1 recognizes TTCA/TGAA and S.AbaB8342I-TRD2 recognizes GGA/TCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases such as Type IIG restriction enzyme/N6-adenine DNA methyltransferases from Thermus scotoductus RFL1 (RM.TstI) and Acinetobacter lwoffi Ks 4-8 (RM.AloI), as well as type I DNA methyltransferases such as Sideroxydans lithotrophicus ES-1 Type I N6-adenine DNA methyltransferase (M.SliESORF1090P). RM.TstI recognizes 5' ... CACNNNNNNTCC ... 3' and RM.AloI recognizes 5' ... GAACNNNNNNTCC ... 3'.	9.91942e-75
NZ_CP019400.1\|WP_015069491.1\|3060663_3061761_-\|PfkB-domain-containing-protein	gnl\|CDD\|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	7.57352e-47
NZ_CP019400.1\|WP_015069498.1\|3069350_3070058_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.31455e-11
NZ_CP019400.1\|WP_015069488.1\|3057480_3058278_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.64651e-69
NZ_CP019400.1\|WP_015069487.1\|3054765_3057363_+\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP019400.1\|WP_015069492.1\|3061894_3062656_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.38825e-73
NZ_CP019400.1\|WP_015069499.1\|3070289_3071156_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.86218e-84
NZ_CP019400.1\|WP_015069496.1\|3066322_3068497_-\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	6.01399e-73
NZ_CP019400.1\|WP_051143621.1\|3068493_3069303_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|365804	pfam00005, ABC_tran, ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide as in CFTR, or belong in different polypeptide chains.	4.33319e-18
NZ_CP019400.1\|WP_015069495.1\|3065640_3066177_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	4.93805e-29
NZ_CP019400.1\|WP_015069486.1\|3053248_3054631_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.93988e-90

>NZ_CP019400.1|WP_015069494.1|3064291_3065224_+|DUF559-domain-containing-protein
MKARTVPPRSLLIFAGEQCDVVTMRQALEGGMTRDGVRGMVHSGRWVRLSSGVFSIGPPTWEQWASAGVVIGGPGSAVGGKAAAFLHGMGPQPEIIDIWAPRGTSYKWRASPHPWDFHRGTRKSIGRPPRLTVEETVLELCSAGGADNVNGWLGKALSDYRTTPDRLRAAIVRAPTLPNRRLILEGIDAVSIGAQSSMEVRYLRDVEKAHGLPRGVRQKSVVAHKFTDVIYEQYKLVVELDGLVGHFGEGENHDTWRDSELLLRGIESMRFGWADVTVRPCEVAAMVAGVLQVRGWDGQMQLCPSCPVPR
>NZ_CP019400.1|WP_015069493.1|3062652_3064002_+|glycoside-hydrolase
MKLAILGGGGFRVPLVHGAVLDQMGPEDGTRIDEIWLHDVSSERLDTMVRVLRGQVAGRPGAPSLHATISLPEAVAGADFVFSAIRVSGLEGRCCDERVALDMGLLGQETTGAGGLIYGLRTLPEAMRIARVVAEEAPGAWVINFTNPAGMITQAMQQVLGPRVIGICDSPIGLGRRAAQALGLDPAATRFGYSGLNHLGWLQSLTVQGRDVLPDLLARPDLLKGTEEGRLFGPEWLGMLGAIPNEYLYYYYFNRDAVAAIRGAAETRGEYLRRTQAQFYRDAAASDDPYRVWVEAHHGRDASYMAEARAEGEERDEADMAAGGYEGVAVAIMRAISAGERASIILNVRNGSALAGLPADAVVEVPCVVDGSGPVPLEPEQLTGHMLGLAATVKECEMGIISAAESGSDAEAVRALAVHPLVDSVTAAGELLAGYRAAIPEVEAVFSGR
>NZ_CP019400.1|WP_015069492.1|3061894_3062656_+|DeoR/GlpR-transcriptional-regulator
MKAIRQGQIQAMLARHEICTVAELVRGLGVSPSTIRRDLADLAARGEVVRERGGARSADSSDADEATPFVEVAEHNRLAKEAIARRAVSMVADGDVVIIDIGTTTRLLARHLRGRAVTVVTTSLTVLDELRPDPATEVILVGGVLRRAYHSLVGVIAEDVLSKLSADLAFLGTSGVNARGQVLDTSLVEVPVKRAMLRAAGRHVLLADHDKFPGAGALEVTGVEGFDAVVTDHQTGQEALEMLADRQVEVVVA
>NZ_CP019400.1|WP_015069491.1|3060663_3061761_-|PfkB-domain-containing-protein
MTQQDGNPSPHRPADVVLTGTVFWDLVMTGLPRIPGNGEEIRVQRMATAPGGVANLAIASARLGLRTALVTEMGRDMAGRFCWSTLEQEGVDLSASRIHEGWTTPVTVSMTHDGDRRMVTHQTPPPAGPTTDDGLATVPSPRAALIDLDQLHSADQTRSSGRLSDWVRHAHDAGTVVLADIGFDETGRWDPAVLDGLRHCDLFTPNATEAMGFTRTATARDAARALAARVPLVVVTDGLDGAWAVDSSAGTEIHAAAVPVPPDEVVDATGAGDVFDAALVWGTLAGWPLDRRLDLACLCSSLAVRGLTGSMGAPGWAEVGAWWRGIAGSAADPDLADRFAFLDECELDAPPRLPAPTSIGWNLPA
>NZ_CP019400.1|WP_015069490.1|3059249_3060599_-|extracellular-solute-binding-protein
MKRRDFLTMSAGLALLAGCAPGSGQSTSTGSATAPSAVSTDPAKIGRATLTVWDQEVRGGGNSELTKLIASFQKAYPDITIKRVSRSFDDLTKTLRLALSGNDAPDVIQANNTRSQMGEFVKAKYIIPLDSYATAYKWNDRYSESLRATASYSTDAKTFGSGTLYGLPQMGEVVAIYTNKSKLSSLGIKSPSTWEEFEAALARAKSSGEVPLAFGNLDKWPAIHILGVLQGQYEQPAAARKLGYGDAGASWTSEGNRKALTKFQEWVTKGYFTPGFNGLGYDPAWQQFSKGKGVFLIAGTWLAADLTTAMKDNVGFILPPPAKAGGVSYTTGATSLPFAITGKCKNPDAAAAFINHITSSEAMKVIAETGNLPVVESDKQKAPDALSKQLFDAFGTTTKNDALLPYLDWATPTMSDTLGAALQDLLAKRASVDQTAQTIQKDYGDFTSK
>NZ_CP019400.1|WP_138575432.1|3058277_3059120_-|sugar-ABC-transporter-permease
MAWLYILPGFLIYGLFLLYPLIRSVQISLYDWDGLTLGTWAGLGNYAKVFTDVSLRGAFGHALVLMVFFAVLPLVIGLVLAAAINHGKVRGLSFFRTVIFLPQVVAMVAIGVAWRHIYEPDGPLNQALQGIGLGALARAWLGDYTWSLPAVGFVGTWFEIGLVTILMLAGMSRIGRDQYEAARLDGAGPVREFFAITLPSVRGETAVALTMTVIAALKTFDLVYIMTKGGPGNQTSVPSYEVYHRAFELGNVGTAAAIGVVLTALIFVISVGIQRLGRQD
>NZ_CP019400.1|WP_015069488.1|3057480_3058278_-|carbohydrate-ABC-transporter-permease
MRTSRSETLVNYLILGIFAVFALAPLATLLSSALGHDTGAPGGVANFATAWTQGHFGRSMVTSIVVSVIVVVVATTASIMTGYAFGTMRFRGSTPVFYLFLLGMMMPSEAIVVPLYFDLRSLHMTDTIWAIVLPQTAQSIAFGTFWLRAYFRTSSRELVEAARLDGLNSWQTLWRIVAPVGRPSILTLVVLEFMWTWNEFLIPLVMASSESLRTAPLGLAFFQGQYTQGFTLLAAGAVIVALPVVIAYVFLQRHFIAGMTEGAVK
>NZ_CP019400.1|WP_015069487.1|3054765_3057363_+|ATP-dependent-chaperone-ClpB
MDTNLTTMSRDAVSAASRHALAHGNPSVEPSHLLHALFTIPDNTVGPLVKGLGAEPEQVDRVATEAMRKLPSSSGASVSQPQLSGSFARVIADAQNRAQQLGDSFVATEHLLISLTTVPSDVQPGLAALGLRADALTRAFNEARGDRRVTSEESEGGESALAKYSVDLTERARSGKLDPVIGRDAEIRRVVQVLARRTKNNPVLIGEPGVGKTAVVEGLAQRVVAGDVPDSLKGRRVVSLDLSSMVAGAKYRGEFEERLKAVLNEIKEAEGQIITFIDELHTVVGAGATGEGSMDAGNMLKPMLARGELRMIGATTLDEYREHIEKDPAFERRFQQVFVGEPSVEDTIAILRGLRERYEAHHKVRITDGALVAAASLSNRYITARQLPDKAIDLIDEAASRLRMEIDSSPEEIDTLRREVDRMKMEIFAVEKEEDPASRQRLARLQGEMADKQERLRGLESRWQAEKAGLNRVGELKTQIDGLRTTADKFQREGDFGKASEILYGQIPGLEKEMEAAAQAEEETPRMVSEEVGTTDIAEVVSAWTGIPVGRMMQGEQEKLLKMESRIHDRLIGQDKAVATVADAVRRSRAGISDPNRPTGSFLFLGPTGVGKTELAKSLAEFLFDDESSMVRIDMSEYMEKHSVSRLVGAPPGYVGYEEGGQLTEAVRRRPYSVILLDEVEKAHRDVFNILLQVLDDGRLTDGQGRTVDFRNTILILTSNLGSQFLSDQSLDETARREAVMGAVHAAFRPEFLNRLDDIVLFDPLTTADLSRIVDTNLAKLNSRLAERQITVELTQAAKDWLAMTGYDPVYGARPLRRLIQTTVEDKLARRMLSGQTVEGDAVTFDVSSDSDGLEIVTGDPAPVA
>NZ_CP019400.1|WP_015069486.1|3053248_3054631_+|ABC-transporter-substrate-binding-protein
MLHDISGRALSRRSLLGLAGIGVSAAALTACSGPSTTATAASASSSASGGPSFTGVTPAKSISFWSNHPGGSQAVTQSIIDAFKKQSGITVKLVTAGSSYEDVAQKFQSAQAGGQLPDLVVLSDVWWFRYFMQDSIIPLGNVLKAAGLSLSDYRPGLVADYQYKGEQWAVPWARSTPLFYYNKSHFKAAGLPDRAPATWAEFAAWGPRLMAVKAATKAKYAYEVPALADYAGWTLQNILWGYGGGWSKKDSFDITCDSAASIAALQVVADSVRRSKWAGVASTAAIDDLAAGACSSTIESTGSLVGVQKAVGSRFEVGVGNLPGGPAATRPVCPTGGCGVGIPKGIDKSRQLAAAKFIAFLTNPQNTVTFSGATGYLPVRTSADTSGLLAKNPLIGTAISQLDVIRTQDWARVFMPGADQEMAKSVAAIVSQGAEVSTTMKALRTTLEGIYTSQVKPHLG
>NZ_CP019400.1|WP_051281536.1|3052310_3053216_+|carbohydrate-ABC-transporter-permease
MSLVLNRTRVRIPKAAGVPADESIVGPDPWTRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFIKLVLAITSGYAFSFLRFPERRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGLGTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGDPSAYPVLMAGAVVVIAPVLLIFLFLQRHIVAGLTQGAVK
>NZ_CP019400.1|WP_015069495.1|3065640_3066177_+|Hsp20/alpha-crystallin-family-protein
MALVEYNPFRGLDRFFDQFAQMASGDSRLMPMDLYRDGDDFVARMDLPGVDPSSIDIDVHDNVLTVRAERKANDVKHDEHSGWVSRERSYGSFARQLSLDSSLDASRITADYTDGELVLTIPVAEEAKPQKIQVTQGQHRAVTVGTDESDASEQKAETSTDAKAAPEPMGPSEPEHHN
>NZ_CP019400.1|WP_015069496.1|3066322_3068497_-|YhgE/Pip-domain-containing-protein
MTSFLRLIQFEFRRFKGKSKLALIFILVIPLLYGGVYLHANWDLYNNTDKVKIAVVNHDRPASYAGATVDGGAAFEQALKKQGTFDWQFLGTDDDKANEGLRKGDYYMVINVPSNFSTNIVSAGNFKPARASLQLHRDDANGFIIGLLTSQVDNAVGKTLDATVSQTYFDALFVNLGTIKSSLGTASSGAKTLDTNLATATKGVKTMNDSVLGATKSLSGLSAATTKNSDALNNIDTASTKLSTAMTQAQGGVNTISSAAGDLTGDAKKMTSSTAALADKAAKDYPTIKAKAANLVTATGRMQNSGTIQTQTDINASLTSLASLEASHPDLAKDSDYVALRKQLNAAATANTTVTANVNTVVNASAGLNLQLNQSDLDKLAADAKKDAANLNADADKVNKGVQQLNSAMKTADDGVQNIDKGVKQATSAGRDLLAVAPKAIDGVMQLSNALGSLNTAMPQLSNGMHTLATGLDKGNKQIPDLSDRQRTNLADVMSSPVDITQTVDHSAKYYGRGLAPMFLSIAMWIACISTFLVVRTASGRSLTGRANSLKIAMMGFGPLATIGLAGSFLMVAGVWLLLGLDPVHPWLFIGFVTVTSLAWMALAYWIRLILGSPQTAVFLILLVLQLPTCGGTFPVTMLPPFYQKLSVIMPMKYSVDTFRALISGGQMSTVGLGFGVQAGILAASIGLIVWLIRRHKIFRMRDLHPPMVTSTTTADYAFSVRPR
>NZ_CP019400.1|WP_051143621.1|3068493_3069303_-|ATP-binding-cassette-domain-containing-protein
MSPTGASPSGSGLVLHARGLTASGSRGVIFGPVDLDLSPRQLTVIHGPKGTGKSALLLALTGRFRRTRGTLIIDGIDAIADPYRAIRRTSVATIGDYVQPEDRLTLAESVAERSYLDSVPLAHAEDRMRRIEELVGYTIERSTELEQLTAMERAIASVALAMIRPSKLIVIDDADVMVPHAEQKELFEIFLRMTELDDSAIVATTVDDDMAPPGSIDIALPARHRAKVHPISGEQVAASPATPDDADDSADGDPSHAPSSTQATEVTDS
>NZ_CP019400.1|WP_015069498.1|3069350_3070058_-|TetR/AcrR-family-transcriptional-regulator
MQTATHPDLTVETDNTTRDDAPGAVSPADAPAHAPLPGRPSHDSVRAKILEAAAANFEEFGYAGTNLRKIASDAGFTKGAVYSNFGSKPDLFCQVATERMSGAGADVFASLTPVLATAADRRELVEGLGRALTQSLLGYTAWELIIAEFRGLAPTDPQVAAGYAALSRERIDRLIELLVTSPLLAELADPDLRSLAAGALGLLNVMAVDHIAAPEVYTEDFITEIVTHAVEGLIR
>NZ_CP019400.1|WP_015069499.1|3070289_3071156_+|NAD(P)H-binding-protein
MTIAITGATGQLGGLVIDSLLARVPATEIVALARNTEKAAGLASRGIDVRHFDYNQPEGLEPALKGVDRLLLISGNAVGQRIPQHKAVIDAAVAADVEFIAYTSFLHTEEASIIAVAPEHKETEKLLAAAPIKVGLLRNGLYTENFIPQAQQAAETGTLLTSAGAGRISSAVRKDFAEAAAAVISAESADDAVYELSGDESFTYGDLANVIAELTGKPVALKNVSAEEHEQILKAAGVPEFGIGFATSTDLAIKEGELFDEHPGTLSKLIGHPTTSLKDALAPALTQG
>NZ_CP019400.1|WP_095532344.1|3071306_3071570_+|ribbon-helix-helix-protein,-CopG-family
MPMTEMINGRPVTEDQIAEWAAEAEAGYDVEKLRRRGRGRPGRGAQPSQAVAVRLTPDELAEVDERAAAAHKTRSAYIRGVLLPESA
>NZ_CP019400.1|WP_015069502.1|3071809_3071926_+|ribbon-helix-helix-protein,-CopG-family
MTVRLSESELDAVMARANREHRSRSDAIREALDEWAHA
>NZ_CP019400.1|WP_154662003.1|3072053_3074630_-|hypothetical-protein
MEIQGTLANRLDEALCASGTHWSDPTDHLSRALRLVELTYPAIAATIEDADRAQLCESWAQQRDATVRKVLYELAGPDAAFSAQDLAQVLRQRSAARRTVRLQAFNTDEAALRSYLERIHMPNVPSGSVVVLQGDFGSGKSEVAETWHRACINELAMGDIAPIPVWFNASAMTGMSLENALDAQTGHAWRRGQGASITIDGLDEIEPATAQALLDASRVLAKTYTSIRVLLTSRPGILTPTTDEEQAIDLLSASDALDLVEAIGGERRETWRWTTDMRETVRRPFFALAAGIMLASGSVPDGEADLIRNLVEHALATGAERQAVTSSTTRGVLEKLAVRLTHSGRDGLSFSDRQVARSSRLVADGPQGSVIFSLPIFQHWFAAQAILAGDVPPEDIVATRQSFVRWRWAAAVAVMSLTDDSQIDELLGTWVSGNPGAAAWIIREAFSGRGNFHTDADGSLDAISSRRRILRALRTWTNGLGPFAPGLLPDSLVHGPVGLGVAVSGRCINIAFAEPSPKSDYVTELPEGIHPLSWGSISKPAWIPWMCGGVPRGSAWPWTMTRELIARETLKKLSNDPHLGTSDGIWTQERRFDLSRVLLRRGRQSLDPLPADEVRTRAVELFESLGGNRKSSVTFNLGGSYSGAELEDLILSIDTNRPSVIASPLPQPDLNPPPPSSWIWEWYSQQRIMEFEVAVYSRACKAYDEALDNAFARLGWSMSSSILAPFGVVMRLNLNDDDSERRLRDRWGSISLSLTRVPMALLPELAPTDPEPIWSTDRRVVISRSEVSLETAYFSWVLERIGSWLQMQERELIGGLSWSTTIANQMSKVRPACDIAAKWLYDDLKKTGLGEGTFPQLR
>NZ_CP019400.1|WP_027588481.1|3075012_3078171_-|type-I-restriction-endonuclease-subunit-R
MISEADWEADMLDWLGELGWEPGTGSDIDGQRRSAADLVLQTDLLNALRRLNPDVPDQRLAEAAAEITAPKSQDAIAENERLHDFLVHGFRGLTYIDTQGREQTPTLRLLSDNPTENTYRAIHQVTIVSGQHSRRFDVVLYVNGLPLVIAELKKASASATITDAYNQLQTYLAEFPTAFRTVVATVISDGLEAKYGTPFTPSNHFTPWNLNDQGDRIDDDNEGLQHLCYGLLEPRRFVDIVKHFVTFEHDDGVTKKIAKPHQYMAVRKAVERTLTAVDSNGKAGVVWHTQGSGKSMEMELYANLVMSDPKLLNPTIVVITDRRDLDGQLYDTFARSTLLPEKPTQIRRRQELRDSLSNRNSGGIYFTTLQKFGLTDEERGRGADHPLLTDRHNVIVIVDEAHRSHYDDLDGYARHLKDALPHGTLIAFTGTPISEPERNTRDVFGDYIDIYDLTQAVEDGATVPVHFEPRLVKVSLASELTPEEIDEAADKETAGLDDSERERIERTVAVINAIYGAPERLEALARDIVTHWERRRDLMDEYLQPSDPDDDAVPHGKGIIVCSTREIAAKLYDEIVKLRPGWHSDDDRTGVIKVVYSGSASDPDPIQKHVRRESQNKAIKNRLKNVNDELELVIVKDMMLTGFDAPAWHTMYLDRPLKGAQLMQALARVNRIFRGKKDGLLVAYAPLADNLKKALGEYTTRDAQNEPVGKNISEAVRETRRLVEALRALLAGCDWRPVLAGGGRRAAKDAVSMAVNYLRSPSTPGNRVEEGQATLKERFRMLSGQLGRMWALSAGSEHLDDLRHEIRFYEEVRGWMAKWDAREREALGQPIPEDVRRMLKGLVAEATAAGEVTDIYAEAGIDLPDLRELTPEKAEELARSDKPQLAIEALRDMLMAEAKAATAHNLTRRTMFSERINGLMIRYTNQQLTSVEAITLILGMAGDVAAEAARGERFNPPLSADELAFYDAVSQNDSAVELMGDDVLAEIARELVGVMQRDTRTDWRVRADMQAKLRVSIKRLLRKYKYPPDKQPAAVKRVIDQMEELAPRYPTK
>NZ_CP019400.1|WP_076692615.1|3078171_3079275_-|restriction-endonuclease-subunit-S
MLRKLTDCCESIDYGFTQSSSAEEIGPHFLRITDIDPECIDWESVPYCEASPAERNKYALAAGDIVVARTGASTGNSRWIESPHGSVFASYLVRLVARPEVNSRYLSYVLKGAQWNHYVSSISSSKSAQPNMSASAMGQFTFEIHSLPEQQAIAEVLGALDDKIAANRKLVTTSLTLAEAVHDLALSDEQRPLGDFMEFAYGKSLPATRRIPGEVPVVGSGGVTGSHDEALVNRPGIVVGRKGSMGTVRWMDEPFFPIDTTFYVTNKTGIPDQFWYFSLKQARFEGLNSDSAVPGLNREAALEQLTRTPSESGIKRFEDFALPLFELATANRRESQTLSQLRDTLLPALMDGTIRVKDAERLTEEAV

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Crispr_ID: NZ_CP019400_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_14

3401319-3401429

Orphan

Consensus_repeat	Method
GACCTGACCCGCTCGGGGAGGCAGGAGCGCAGCGACGTGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019400_14

>merge|NZ_CP019400|14|3401319-3401429|CRISPRCasFinder
GACCTGACCCGCTCGGGGAGGCAGGAGCGCAGCGACGTGGAGTCCCGTCGGGAGTGGGACGCGGTCGCGGACCTGACCCGCTCGGGGAGGCAGGAGCGCAGCGACGTGGAG

>NZ_CP019400|14|14|3401319-3401429|CRISPRCasFinder
GACCTGACCCGCTCGGGGAGGCAGGAGCGCAGCGACGTGGAG	TCCCGTCGGGAGTGGGACGCGGTCGCG
GACCTGACCCGCTCGGGGAGGCAGGAGCGCAGCGACGTGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_051282015.1\|3402392_3403073_+\|hemolysin	unknown	unknown	gnl\|CDD\|224191
NZ_CP019400.1\|WP_028701444.1\|3394213_3394843_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|234604
NZ_CP019400.1\|WP_028701446.1\|3395722_3396901_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP019400.1\|WP_028701449.1\|3399032_3399233_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015069782.1\|3405178_3405433_-\|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|179195
NZ_CP019400.1\|WP_028701455.1\|3407718_3408990_-\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|376878
NZ_CP019400.1\|WP_028701443.1\|3393369_3393819_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028701447.1\|3396912_3397947_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015069778.1\|3401449_3402271_-\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NZ_CP019400.1\|WP_028701453.1\|3405429_3406695_-\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|272979
NZ_CP019400.1\|WP_028701452.1\|3404652_3405171_+\|DUF4245-domain-containing-protein	unknown	unknown	gnl\|CDD\|379430
NZ_CP019400.1\|WP_036937985.1\|3406826_3407795_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl\|CDD\|234893
NZ_CP019400.1\|WP_015069775.1\|3398542_3398983_-\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NZ_CP019400.1\|WP_015069769.1\|3393815_3394205_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_028701445.1\|3394934_3395612_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP019400.1\|WP_015069780.1\|3403230_3404595_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NZ_CP019400.1\|WP_015069774.1\|3398000_3398498_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP019400.1\|WP_028701450.1\|3399271_3401308_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NZ_CP019400.1\|WP_028701459.1\|3410995_3413386_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NZ_CP019400.1\|WP_028701456.1\|3409114_3410392_+\|M18-family-aminopeptidase	unknown	unknown	gnl\|CDD\|235073

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_051282015.1\|3402392_3403073_+\|hemolysin	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	5.05709e-45
NZ_CP019400.1\|WP_015069774.1\|3398000_3398498_-\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	1.47607e-57
NZ_CP019400.1\|WP_028701446.1\|3395722_3396901_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.24023e-43
NZ_CP019400.1\|WP_028701455.1\|3407718_3408990_-\|DNA-recombination-protein-RmuC	gnl\|CDD\|376878	pfam02646, RmuC, RmuC family. This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures.	1.2972e-113
NZ_CP019400.1\|WP_015069782.1\|3405178_3405433_-\|exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	1.98944e-17
NZ_CP019400.1\|WP_015069778.1\|3401449_3402271_-\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	3.61711e-118
NZ_CP019400.1\|WP_028701453.1\|3405429_3406695_-\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|272979	TIGR00237, exodeoxyribonuclease_VII_large_subunit, exodeoxyribonuclease VII, large subunit. This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA].	2.17334e-142
NZ_CP019400.1\|WP_028701452.1\|3404652_3405171_+\|DUF4245-domain-containing-protein	gnl\|CDD\|379430	pfam14030, DUF4245, Protein of unknown function (DUF4245). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.	5.61397e-40
NZ_CP019400.1\|WP_036937985.1\|3406826_3407795_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl\|CDD\|234893	PRK01045, ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed.	4.99818e-174
NZ_CP019400.1\|WP_015069775.1\|3398542_3398983_-\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	2.04323e-29
NZ_CP019400.1\|WP_028701445.1\|3394934_3395612_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.14033e-121
NZ_CP019400.1\|WP_015069780.1\|3403230_3404595_+\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	6.63752e-179
NZ_CP019400.1\|WP_028701444.1\|3394213_3394843_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	9.01747e-104
NZ_CP019400.1\|WP_028701450.1\|3399271_3401308_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP019400.1\|WP_028701459.1\|3410995_3413386_-\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.39358e-07
NZ_CP019400.1\|WP_028701456.1\|3409114_3410392_+\|M18-family-aminopeptidase	gnl\|CDD\|235073	PRK02813, PRK02813, putative aminopeptidase 2; Provisional.	0

>NZ_CP019400.1|WP_028701450.1|3399271_3401308_+|thioredoxin-domain-containing-protein
MPNHLADATSPYLLSHAANPVDWFGWGSDAFDEARSRDLPLLISVGYSSCHWCHVMALESFSDPEVAEVVNEYFVPVKVDREENPEVDASLMQATLALTGSGGWPNTVFCTPDGRPFFAGTYFPPEPRDGQPAFVDVVRALGQAWQERRDEVVQQAGVITDQLRAMASAQEPDDGAATGMPTAQELLDAVSTDYDIVNGGFGGPTKFPTPTLIDALLVKGDPTSLDMAQNTCEHLVRGGIFDQVGGGFHRYSTDSQWTVPHFEKMLNDNGLLLGTMARCWRRTADHDPDRRALYDHAVRRTVDWLRREMTTEEGLLAASLDADSDDLAGHTHEGIFYLWNTQLLVDALGEEEAGWLRPLLHLGDQGNFEGDLSTLQMRGRLDWERINADLDRMLEYRALRSRPARDEKVVTAWNAMVIDSLVEAGMILREWSWVEWAGELADKLWRAHWQGGRLLRTSLHGRPGTGAVTEDHAHLGLALAGLAGATGRRVWLDRAVEVLDAAVDRFSEPDGGFADAAASDLVVAPARTLTDDANPSPTSAMVKALRRVGLMAGREDLVERADLASRRLARVVVGAPRYAGWALADHLISDDARRGLRPAAVVVVEEDAEPGELAAAAWRMAPSGSALMRGAAGTDGFAEWFDERGDEQGPTAYVCRGTVCFEPVTDYLELKDPLWRRV
>NZ_CP019400.1|WP_028701449.1|3399032_3399233_+|hypothetical-protein
MPVQLISPGILNLIVFLALAAFGVIAWFSIRHNIHGIDFDEVPSGPELKSGPDRGEEGSGETGPRQ
>NZ_CP019400.1|WP_015069775.1|3398542_3398983_-|DUF4307-domain-containing-protein
MSPVTHGATQPGGRRLSPQEQERLAQRYPQRRRRLWIPLACLAAALLVGWTVWSGLHHSAEPMRVQLFGYQVVDATRVDVTVDVHRSDPSVSGSCTLYALSHDNQRVGEAPLRISPAGDQDVRIRAHLKTFSRAVTAQLENCQASR
>NZ_CP019400.1|WP_015069774.1|3398000_3398498_-|transcription-elongation-factor-GreA
MPESQDTVWLTQEAYDKLTQELAHLKGEGRTEISKKIAEARSEGDLSENGGYHAAREEQGQAEARIIQLDHMLRNAQVGEKPAGSHKVVPGSKVTVCYFGDKSDTETFLLGSREMMGLDDSVDTPVYSPQSPLGAAVLDLEIGATASYSAPNGKTIEVTVLDVAG
>NZ_CP019400.1|WP_028701447.1|3396912_3397947_+|hypothetical-protein
MSATPDLSGILADLAAGRIDAAEASRRIDAANRQADDHDEKEAPAPGPEDGPAGRNGEESKQNEERADGGSARGDAGPRGFFDESWNRVPPEAREGLRSAWRRVAGAAESVVDAASGQSSPRSAQRGPAGSEAGPRDTVTRLSVRCVGRRVTIIGDPGTPGVQVEGKHNRRRIGDVVEITSEGRIAPDLSGLLKLRFPKDAEGLKDLGLGPELIIRMHPDLALEVELAGGALRLSGVPDVDSVRVTAAVADIADVHHIGEALFQAGGSTLAGPIDTGRSRIRVESGNLTVRLAAGANVAIRADARPGLISWPDGGASVDEYIVGNGAARMDMSTVMGRIAVRTA
>NZ_CP019400.1|WP_028701446.1|3395722_3396901_+|AI-2E-family-transporter
MTDRHTSDASGDETDDAIPRGLRTAAGWSWRVLIIAALVAVVAFALAEISEVSIPVAVALMLTAALWPLANFLSRHRVPRGLASGLCLLALIVVIGGIFTLVGAQIASQWPVLSEQSVASFKQVMQWLDKGPLHIGSDQIDAYIAQAEAWAKGSQSRIASWAAAAGSGVGRFLTGLIMALFATFFFIYQGGSIARSVSVLIPTGSRPRILDAARSGWVALVGYVRAAVIVAFVDGLGAGIGAAIIGSGVAVAIGALTFVLAFIPIAGALIAGVISVAVVLVTLGFVKAVIMLLIFVGVMELESHILQPFLLGKAVSIHPLAILLGIAIGSVLAGIVGALFAIPLVAFGVAFAKALAHRYSEDGQAEPDEKPDEEETGAEDDELKDEDADATS
>NZ_CP019400.1|WP_028701445.1|3394934_3395612_-|uracil-DNA-glycosylase
MTAQPLSQLVAEDWAEALAPVEPVIHEMGDFLRSELAAGHGYLPSGDRVLRAFSRPMSQVKVLIVGQDPYPTPGHAVGLSFSVERDVRPLPRSLQNIYAELQSDLGIPPCPHGDLTGWFEQGVLLLNRCLTVRPGKPASHRNKGWEKVTQLAIESLVARGGPLVAILWGRDAQTLEPMLGDIPVVKSPHPSPMSARYGFFGSRPFSRANELLEKQGAQPIEWRLE
>NZ_CP019400.1|WP_028701444.1|3394213_3394843_-|peptide-methionine-(S)-S-oxide-reductase-MsrA
MSGDKIIDPVHALPGRSTPFLAMPFRHRVLGAPLNSHFDNAQEIYLAFGCFWGAEKLYWQTEGVLMTAVGYMGGVTPNPTYDEVCTGRTGHAETVRVTFDPQVLPVEEVLRLFFENHDPTQGMRQGNDVGAQYRSAIWCTGSGQYIAATAIRGQYQGALLGEGYGQITTTIEMAEGHPFYPAEAEHQQYLEANPFGYCPVHATGVCLVR
>NZ_CP019400.1|WP_015069769.1|3393815_3394205_+|hypothetical-protein
MSLRTAEHMLVTSYDDEGRAQTSLEQLVAVDDGQVGYWLANDQGVRDRFPDDCVVSVRAATSRGKPVIEEPVIEGRASVLADGPDFDRVKAGIREKYPSRSWVSTAMDRTREIFGGRTPECVVLIHLLG
>NZ_CP019400.1|WP_028701443.1|3393369_3393819_+|hypothetical-protein
MMKAVKWVLIVLGAVCLGVGLYMVIRLSMDMRTIMGAANAGKSVDVLQNPMRTVWIVGAVALGAGALLGAGIGLPRRTLGSVRRETLEGAAAQRESAIRENALRRAGRPRPEAATGDGELPAGSDRPQLETSADPETDDEAGKDDGGAR
>NZ_CP019400.1|WP_015069778.1|3401449_3402271_-|isoprenyl-transferase
MHPAEHYIAKAGELLDRLHPSGLLYNTYEARLLDQLDRTRLPQHVAVLADGNRRWARLNAPGEPLVAGYQAGSDKLQAFCHWCDGVGIPVVTLWVLSTDNLQRAETGELGPLLKIIESLVITLARNPRWRVQTVGDMGLLPDDMAASLAEARKATADHDGMHINVAIAYGGRHELRDAVRSLLAEEAAKGTSLEELSQSLEIDQIAEHLYTKGQPDPDLIIRTSGEQRLSGFLMWQSAHSEFYFCEALWPDFRKVDFLRALRSFTQRERRYGR
>NZ_CP019400.1|WP_051282015.1|3402392_3403073_+|hemolysin
MKTVVPERRRLLAAPAEVEPAPRLRGWIHTVMAPLVLVTGLGLIIAGDSWGNRFAVAVWICTGLALFGNSAVYHRIPWAPRIKAVLRRIDHANIAVFIAGTYTPLAVSMLTGASRVVLLSVIWGCAAAGVVFRVLWTDAPRWLYTGLYIVMGWVALWWLPQFWRSGGAAVVILILAGGVCYTLGAVAYARRRPDPSPTWFGFHEVFHAGTALGAVCHAVAIGLAVI
>NZ_CP019400.1|WP_015069780.1|3403230_3404595_+|PhoH-family-protein
MPTHSDPSSRLRAAIPTPGRGRRTYVVDTSVLLSDPRALLNFAEHHVVLPIVVITELEAKRTHPELGYFARAALRILDRLRIENDGLQRPVPLNDEGGTLNVELNHSDPGCLPDGLRLGDNDTRILAVAANYRQAGHRVVLVTKDMPLRIKASAIGLEAEEYRHELARDTTWTGMVELEVSDEVIGRLYRDGSLALDGADGSPGADDLTVNSGLVLQGPSSTALARTMPDQTARLVRSDQEVFGIHGRSAEQRVALDLLLDPEVGIVSLGGRAGTGKSALALCAGLDAVLERQIYQKVLVFRPLYAVGGQELGYLPGNEGEKMAPWGQAVMDTLTSVTNSYVIDEVLERGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGQNSRVVLTHDVAQRDNLRVGRHDGVAAVVERLRGNPLFGHVTLTRSERSPIAALVTRMLEDLV
>NZ_CP019400.1|WP_028701452.1|3404652_3405171_+|DUF4245-domain-containing-protein
MLRSLAVILIPLLVIIWVFTRTPDEPQVDPVDWRPAVADARSGAGYPVLAPVEVPTDWKPVKARYVDRGGQWVGSTQAAGNRWELGFRSGDDIYMAVNQSDEPGKDAYIGSVTRSSHPDGTSTIDGQTWQRRVSQDGRTRSLVRAVGGSTAVVVADTGYPALESFAQTLRTS
>NZ_CP019400.1|WP_015069782.1|3405178_3405433_-|exodeoxyribonuclease-VII-small-subunit
MTEQPQETTSPEATTDPEIGYEQARDELVEVVRRLESGGTSLADTMTLWERGEKLAAICQTWLDGARRRIEEARSASEGGPEEA
>NZ_CP019400.1|WP_028701453.1|3405429_3406695_-|exodeoxyribonuclease-VII-large-subunit
MASSSTPPEQTRSLAWVVRAVKDWVERCGKVWVEAQVIELNRRSGPTQFLTLRDVEEEISVTATCHRRVLDAAGPVESGMTVTALLRPTVWSRTGRLSFECSEIRPSGEGRLLAQLERRRRLLEAEGLFDSRLHKPLPLLPRGIGLITGARSDAERDVIRNATLRWPAVRFVVRNTLVQGARAVEQIIGALAELDADPGVDVIVIARGGGSLEDLLPFSDETLVRAVHAARTPVVSAIGHEADSPILDLVADLRASTPTDAGKRIVPDVAEELAGLRDVTARIRQSVASRIATEQSWLDSVRSRPVMMDPAATLDIASERLGATLARLRLATDRALETESREIDHQLRSVRAMSPKATLDRGYAVLADADGASVGSVSATREDARLDVYLSDGALGVTVDAVRPGGPATPTTPSPQKGTKS
>NZ_CP019400.1|WP_036937985.1|3406826_3407795_+|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MPDAPRKLVLAAPRGYCAGVDRAVITVEKALESYGAPVYVRKQIVHNRHVVETLEERGAIFVDELDAVPDGALVVFSAHGVSPAVKSEAARRGLRTIDATCPLVTKVHHEARRFSQEGAQILLIGHAGHEEVEGTTGEAPQDITLVQSPSDVDGLELDPDRPVAWLSQTTLSVDETAETVQRLREKTPDLVDPPSDDICYATTNRQQGVKQIAAHCDLMIVVGSRNSSNTLRLVDVALEAGARAAHRVDDAGEVKDSWLDGVAEIGVTSGASVPERLVQEVVEHLQGRGWPAPEEEQLIEESLSFALPPQLRSRRTRSARAH
>NZ_CP019400.1|WP_028701455.1|3407718_3408990_-|DNA-recombination-protein-RmuC
MTSMTTSHFVVLFIGLAIGLVVGWLLAELRARSALAQATSRADVAEAHRQAAEERAELTAGDRDSLADRFRALSAEALNTQQLRADRAAERTATDTQRLLAPVSQALEKLEHRLGEVERERSAMTARLGQQVEMVNAAGEGLRKETASLVTALRKPQVRGAWGEVQLRRVVELAGMVEHCDFEVQSTTTASGKALRPDMTVRMAGGRCVHVDAKTPLSAFLDAAATDDPDERAAHMAHFARNVRGHIDDLSSKGYWRTEVDSPEFVVLFLPSDAFLQAALDQIPDLHEYASRHDIVLADPSVLIPMLRVIALAWRQEDVARSAAEVAALGRDLHDRLGTLSTHLDKLGRSLTGAVRSYNSAVGSLETRVLVSARRFETTGVTTATLPSPGTVTDAVRPLSAPELTSSDDSEAEEEARRTTTPR
>NZ_CP019400.1|WP_028701456.1|3409114_3410392_+|M18-family-aminopeptidase
MTSPARAHVDDVISFVESSPTSYHAAAELARRLEEAGFERLDETADWSGAASVEGRRFVVRDGAVIAWATPETIGPRAGFRIVGSHTDSPSFKLKPHATFTNLGWQQVGMEVYGGGLLNSWLDRDLGLAGRLVTLDGETHLVRTGPILRISQLAPHLDRTVNQDLTLDRQRHLMPILSVGRPDLDVEDLLCEEAGIDRSRLGFHDILAYPTERPAVIGPAGEFLASSRMDNLSSVHSSIAAMVDVEVGEDIAVMACFDHEEVGSSTRSGACGPFLEDVLVRIADGLGRRGDAYRAMIARSTCISSDAGHGVHPNYPEKFDPANHPLLGQGPLLKINANQRYATDGVGGALWQRVCRAADVPTQAFVSNNSVPCGSTIGPLTATRLGMLTVDVGLPLMSMHSTRELAGVADLSSLSTALGAFWAGA
>NZ_CP019400.1|WP_028701459.1|3410995_3413386_-|ABC-transporter-permease
MPHHLYLRYIRSDLRRNRAVTLCLALVLTLSAFLMAGGAIMMERLAGSVGQIFTVAKPPHFLQMHQGTINRPALQRFSVNHPEIEAWQICEMIGFDGQAISWQRTGDDAGGDLSASLIDNLFVTQNRQFDLLLDAGADTAPRPAAGEVRVPVAYQQQFGLRAGDRLRIRTGSGTTSLRITGFVRDAQMASSMSSAIRFLVSPADFQRLSASGGGIPESIVEYRLRDTAGIGNLQRDYEADPALPRNGQAVTLVMIRLVNMVSDGLVAIALVFASLLLIVIAMLNVRLLIRATLEDEIHEIATMRAIGLPARDISSLYGLRYGILTLAGCLVGGALAIPAVGAMTAPMRATFADPPITWITVAAPLLALTVVLGIVMWLCRATLRRVRRIDIVDALVHGSTGPRKGRRRGTAPRSRLAGARPGRLWARLALAELRDERGRWVLLPVVFGLTTVLVTVPANVLATFQSPRFVTYMGAPSSDMRADIGSAAASGEPADDAHARLRSQLAGDTRVSATHDYAQLLYQTYGEDGWETIRIEVGDYSHTTMVFLSGAAPSAGQIAVSALNADKYGLSVGDTISVRRDDRSRSLTVSGIYQDVTSGGYTAKMQGAITAGADRWTVYIDLDPGADPVSLARQYNAAVPGASVIPMLEYVTQTFSYATDALHTASLVTLWLGLAASALITALFLRLRLARSRAGLATLSSIGFPSTELRAQLWLKAVLAVTIGVAAGSIIAATLAGPAVSALLSGLGTGITRLTLLPNPWISYLAYPLLLLTAGALATWVTARQIRDGRPLRWLS

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Crispr_ID: NZ_CP019400_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019400_15

3614594-3614685

Orphan

Consensus_repeat	Method
GGGGACGACCCCTCCACGTCGCTTCG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP019400_15

>merge|NZ_CP019400|15|3614594-3614685|CRISPRCasFinder
GGGGACGACCCCTCCACGTCGCTTCGCTCCTGCCTCCCCGCGCGGGTCGGGTCAGCGGTCGCATCCGGGGAGGACCCCTCCACGTCGCTTCG

>NZ_CP019400|15|15|3614594-3614685|CRISPRCasFinder
GGGGACGACCCCTCCACGTCGCTTCG	CTCCTGCCTCCCCGCGCGGGTCGGGTCAGCGGTCGCATCC
GGGGAGGACCCCTCCACGTCGCTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019400.1\|WP_028701697.1\|3619526_3619940_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_015069986.1\|3626900_3628049_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270271
NZ_CP019400.1\|WP_015069980.1\|3620087_3620777_+\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|238317
NZ_CP019400.1\|WP_071162015.1\|3625292_3626507_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019400.1\|WP_051282098.1\|3608618_3609740_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP019400.1\|WP_097959137.1\|3616881_3617829_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP019400.1\|WP_081685444.1\|3605547_3606192_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NZ_CP019400.1\|WP_148279620.1\|3613948_3614584_+\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP019400.1\|WP_028701694.1\|3614764_3616159_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP019400.1\|WP_028701692.1\|3610914_3611685_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP019400.1\|WP_015069976.1\|3616232_3616880_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225130
NZ_CP019400.1\|WP_051282097.1\|3606552_3608367_-\|DEDD-exonuclease-domain-containing-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236123
NZ_CP019400.1\|WP_015069965.1\|3604954_3605467_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_CP019400.1\|WP_028701698.1\|3620798_3621899_-\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NZ_CP019400.1\|WP_051143638.1\|3622804_3625006_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP019400.1\|WP_015069972.1\|3611681_3612536_+\|phospholipid/glycerol-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP019400.1\|WP_081685438.1\|3612447_3613746_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP019400.1\|WP_015069982.1\|3621960_3622878_+\|5,10-methylenetetrahydrofolate-reductase	unknown	unknown	gnl\|CDD\|273212
NZ_CP019400.1\|WP_015069970.1\|3609744_3610830_+\|ROK-family-glucokinase	unknown	unknown	gnl\|CDD\|273246
NZ_CP019400.1\|WP_015069967.1\|3606259_3606535_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366431

Protein	Function_ID	Function_description	E-value
NZ_CP019400.1\|WP_015069986.1\|3626900_3628049_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270271	cd13553, PBP2_NrtA_CpmA_like, Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.44526e-28
NZ_CP019400.1\|WP_015069980.1\|3620087_3620777_+\|thiamine-phosphate-synthase	gnl\|CDD\|238317	cd00564, TMP_TenI, Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl) thiazole phosphate to yield thiamine phosphate. TenI is a enzymatically inactive regulatory protein involved in the regulation of several extracellular enzymes. This superfamily also contains other enzymatically inactive proteins with unknown functions.	6.8516e-35
NZ_CP019400.1\|WP_051282098.1\|3608618_3609740_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	2.66672e-33
NZ_CP019400.1\|WP_097959137.1\|3616881_3617829_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.82549e-16
NZ_CP019400.1\|WP_081685444.1\|3605547_3606192_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	5.69731e-11
NZ_CP019400.1\|WP_148279620.1\|3613948_3614584_+\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.98916e-57
NZ_CP019400.1\|WP_028701694.1\|3614764_3616159_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP019400.1\|WP_028701692.1\|3610914_3611685_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	5.68538e-49
NZ_CP019400.1\|WP_015069976.1\|3616232_3616880_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	2.38233e-16
NZ_CP019400.1\|WP_051282097.1\|3606552_3608367_-\|DEDD-exonuclease-domain-containing-protein	gnl\|CDD\|236123	PRK07883, PRK07883, DEDD exonuclease domain-containing protein.	0
NZ_CP019400.1\|WP_015069965.1\|3604954_3605467_+\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	1.14374e-68
NZ_CP019400.1\|WP_028701698.1\|3620798_3621899_-\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	8.92543e-59
NZ_CP019400.1\|WP_051143638.1\|3622804_3625006_-\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	2.01203e-74
NZ_CP019400.1\|WP_015069972.1\|3611681_3612536_+\|phospholipid/glycerol-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.36584e-11
NZ_CP019400.1\|WP_081685438.1\|3612447_3613746_+\|hypothetical-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.40566e-19
NZ_CP019400.1\|WP_015069982.1\|3621960_3622878_+\|5,10-methylenetetrahydrofolate-reductase	gnl\|CDD\|273212	TIGR00676, 510-methylenetetrahydrofolate_reductase., 5,10-methylenetetrahydrofolate reductase, prokaryotic form. The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family].	7.89656e-109
NZ_CP019400.1\|WP_015069970.1\|3609744_3610830_+\|ROK-family-glucokinase	gnl\|CDD\|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	1.16495e-87
NZ_CP019400.1\|WP_015069967.1\|3606259_3606535_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|366431	pfam01037, AsnC_trans_reg, Lrp/AsnC ligand binding domain. The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold.	1.75817e-13

>NZ_CP019400.1|WP_148279620.1|3613948_3614584_+|response-regulator
MLVDDHPMWIDALGQDLTADGFDIVAVAHDGSECLRRARAAQPDVLVIDLKIPEPDGATCTQLLTTEFPRMHVLVISASGEREDVLRAAKAGACGYMVKSATRAELLDGVRRTAQGDAVFTPGLAGLVLGEFRRMAIQPGGEDDSRPRLTDREVEVLRRVAKGMAYREIAEELVVSHRTVQNHVQNVLRKLQLHNRVELTLYALENGIGPD
>NZ_CP019400.1|WP_081685438.1|3612447_3613746_+|hypothetical-protein
MAARLRGRPTVLPPTTGRPTRVTPMGTSTEQTDGRPEHDGHGGAPHFTPLSTARVQHIVTVLRWVFLAHAVLMTVVRWDTVAHPGWMLALLAVMLVWTAIVTVQSRLRGLRWRPVVAVDLAVSVLVTVTSRVVLGPGVPTAGFEGVGYYWVVCAPLAVALSYGGVAGALAALLMILPGAFGVGHGHLWAWSADLLLLASCWGAGRLMDQMRSLLAENQRSHAITARMAERERLGRIVHDGALQVLSMVEREGPELGERGVVLAGLAREQGAQLRRLLQSAAGESALEADPDSGTVDLVATIEDHGSESVTVSAMAGELLLPAETVHEIDAALQQVLSNVAQHAGPGAHCWILIEQEERTIVISVRDNGVGMSPEQADQASREGRMGISRSIIGRIHDVGGTSEMTSAPGHGVEWEFRVPLDEKGGRPPLNPS
>NZ_CP019400.1|WP_015069972.1|3611681_3612536_+|phospholipid/glycerol-acyltransferase
MSRLPRWTGGQVDLTGEPLPDGPVVVAVHHTRYDDAVVVRAALHAVRSPWLGLVTPTRAVPWGTSARSRALAALRAGRVIVVFPEGSTAPGRAIYKGDVEVAHLALEAGAPVVPALLAEDRSALQLGAPLDFSRHASIPHSRAVLRAVTDEVMEALSGLADLPYHDLPAAAARQEEVQARRERVRADRAGRAAARQKAALQRQEAKAEAAEEAADLAQAAISAREAARSQAREAALADRLRAAGIRPGVPDDGETDGGATPRTPDSAATDDRETDEGDTDGDQH
>NZ_CP019400.1|WP_028701692.1|3610914_3611685_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MWYQVFKVGLFGPGVRALWRPWVVGEENLPREGGAVVACNHISVLDPIIVAAMLDRQMTYPAKKELFQGDHGLWSKIVAWFLKAVDQVPLDRSGGKRSVEGMAPVLTRLGEGGLIGIFPEGTRSADGELYKGKTGVARMALHADVPVVPVALIGTEPVKGRFGIPTVRHPGVIIGEPLHFSELAGRQDEVAVLRWVTNEVMDAIQRLGGQQYVDVYGFRVKYGNLKGKDLSRWRRPRPGGTPAPAPRETDRAGEQR
>NZ_CP019400.1|WP_015069970.1|3609744_3610830_+|ROK-family-glucokinase
MLSVGIDIGGTKVAAGVVDEQGTILRRLKRPTPSHSPEAVENAIVESVAELSVGLGVGAVGIGAAGWVDTEQALVRFSPHLAWRNEPLRDRLATRISVPVLVDNDANAAAWAEYRFGAGQGSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTVVPDGHWCPCGNRGCWEQYASGNSLVRDAKALIAEGSPRAQGLLDHVAGRDPDQLIGPDVTAAAVDGDATAIELIADVGTWLGKGMAGLGAALDPDLFVIGGGVSAAGELLLGPARTAFARNLTGRGFRPLAEIEHARFGPDAGLIGAADLARHSIAEPPGPARGFWPRRRHPRRTVRRRPILHTFTSGFGAPVEQGSEPRP
>NZ_CP019400.1|WP_051282098.1|3608618_3609740_+|C40-family-peptidase
MAQNRQAGSKTRGAEKGRRLGRGLAATALSSAIVVSGLVAGQTRAAAEPDTVSEAKSELAAIEAQSHKLDAQYTTAQANLDKAEKSLKSAEKDLVSQRAKVASMRKTLSALAANDYQNGNISLSAQMVTSGDAGQFLSRLTTMQNVSDRTKSRFQSFQSEQARLQTLEKQAASDRTTIKASRDSQAVLLKKTKAKEDDAKKVLASLTAQEQQKLAREQAAAAQSRANAASQNSRSEVRSDTSASPASPSGSSSNTSASGRAATAIAFAKSKIGGPYVYGGTGPTGYDCSGLMQAAWAAAGVSLPRTSQEQFGAGTSVSTSNLQPGDLVFYYSGPSHVGMYIGGGQIVHAANPSAGIKISSVGEMPITGARHVG
>NZ_CP019400.1|WP_051282097.1|3606552_3608367_-|DEDD-exonuclease-domain-containing-protein
MSSMTAQDLQPSFDDLGTPLFDVTFCVVDLETTGGSGDDEITEIGAVKVRGGEVLGELATLVRPGSHIRGSVQMLTGITDEMVADAPSIGSVLPSWLEFSRGCVLVAHNARFDIGFLRRACDAHDRPWPGNTVLDTLALARSCLGRDEVHDHKLGTLARYFTATTSPSHRALDDARATVDVMHGIIERVSGLGVTTLEDLLEVTHKVAPGRRARRTWADSLPESPGIYWFQADRPTAGQPPEVLYVGTSVNVRRRVRQYFTASETRRRMDEMVRVATGVDALACATTLEAGVRELRMIDAHSPRYNRRSRRQNAVNWVCLTDDRYPRLSVVRSTSRTDRTYWGPFTNRQEAADAGSLIAEFAGIRQCSGTPASHPHGCPLAEMGRCVAPCLTGGGDDPSTLAQALAASPTGSSPRPPSTDPYRGAVDRARQAMTVDVRPLIEAASTRIASLSRQERFEEAAALTSRARSCLRAGRRRARIASLADCAEIVAARPVDRTWEIHIVRHGRLAAAALSPAGQNPVPTIEAARATAETATAAAPGIPACTAEEAELVAEWLETPGVRLVDIDGSWDWPVHCAAEDRALSDAVALASGRITDQECGRTA
>NZ_CP019400.1|WP_015069967.1|3606259_3606535_-|Lrp/AsnC-family-transcriptional-regulator
MFNAIVLIQASSNRIPEVAQEVLALPGVSEVYSTAGHIDLIAMVRASTMEEVAEIIADRINKVEGVVDTDTHIALRTYSEHDLEAMFSIGD
>NZ_CP019400.1|WP_081685444.1|3605547_3606192_+|rhomboid-family-intramembrane-serine-protease
MGDRWAEHPIRPGRSDSPASIVLAAATLVVAVLSNLVPLATWLAAGSSPVFDFQVWRPLLYGLTTGSILQGIINGVFLVLVGRSLEPILGSADFAAVYLLSGLGGATALSLTGVPASFSGAICGIFGILAATAVIKHLEHQDIRGDIILITLFVIWGILAGARDWTADIGAIVIGAVIGWVWARNRWATRGRSRIAYAVIAGVCLAALVVTWLT
>NZ_CP019400.1|WP_015069965.1|3604954_3605467_+|peptidylprolyl-isomerase
MASTATLHTNHGDIVLNLFGDQAPKTVKNFVGLADGTQEYTDPLTGQKTTGRFYDGLTFHRIIDGFMIQGGCPLGTGTGGPGYQFADEFHPDLHFSKPYLLAMANAGPGTNGSQFFITVAPTPHLNRRHTIFGEVADEASRKVVDEIAQVKTDRMDRPADPVVIETVEIA
>NZ_CP019400.1|WP_028701694.1|3614764_3616159_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
MLNGVPNLAELHAMPQMQQPSYPEPAAVADVVSRLRGLPPLVFAGECDDLRDKLAAVADGRGFLLQGGDCAETFAGVNADNIKGKLRVLLSMAVVMTYAAQVPVVKVGRIAGQYAKPRSKDTETRNGVTLPSYRGDAVNGFEFTPESRTHDPRRLLQIYNSSAATLNLVRAFVKGGFADLRGINAWNADFVRNSNVEARYEALAHEIESALAFMIACGVDDEQLSTVDFYASHEALLLDYEHAMTRIDSRSQLPYDTSGHLLWIGERTRQPDGAHVAFMRRVNNPLGIKLGPSTSGEDAVLTAELLDPDRIPGRITFITRMGAGNVREKLPPIIDAVESTGRKVVWTCDPMHGNTFESANGFKTRSFVDVCAEVNAFFDVHEEMGTWPGGVHVELTGDDVTECLGGVDALDEADLANRYETACDPRLNRNQSLELAFMIAERLSDGRLKRHAVSPLEPFRGMDM
>NZ_CP019400.1|WP_015069976.1|3616232_3616880_+|MBL-fold-metallo-hydrolase
MRITHLGHSCVLVEAADARILIDPGNFSDAWHGLTGLTAILVTHAHPDHVDPEHIEELVNANSGAICRAEKGAAAAVPQLDADPIMPGDIIEVGGARIEAVGGQHAVIHRDIPRIGNVGYLVGEGLGTILFHPGDELDETPHGVDVLACPAYGPWAAMKETVDFARAVGARDGFLIHDGLLNERGWRTAFDRHDEMTDTTFHDLRDGRPWEAPGR
>NZ_CP019400.1|WP_097959137.1|3616881_3617829_-|DMT-family-transporter
MVGFRSSRLAPAALMVMALLWGSTLVVMKDAYAHLSPTDLLANRFLVGALALGLLMPRAWRANARTIGKGLLLGLLFGAGQVLQAVGLSSTPASVNGFIGGLYVVVTPLLGAIFFGKRVPRQIWIAVALATVGLGSLALDPADLGAGIGVGELLTFAASVCFAAQIVALGRFATARNVASLALYQTIGAALVCAICAAPGGIRIASSGSEWFAVLYLGVVCSAAIAVLQSWAQARVEATRASVIMCTEPLWGAVFAIGLAGDPVTLRIILGGVSILAAMVMVVRPPRRRRGLTQDEAGPRQIEQAGIGDLVGDSK
>NZ_CP019400.1|WP_028701697.1|3619526_3619940_-|hypothetical-protein
MSIRKPIAAAITAVTILTGCSGHAQEAPSTPSADSDSRQVVTAYLKAAVGHDCQVTRSLTASSTWAWCDKPRMTAYKGIGSVVKLSAQEAGVALECYPMTVTTRDGQGRGLKEGTRPWTLCFQHTEAGYKLYQQGMR
>NZ_CP019400.1|WP_015069980.1|3620087_3620777_+|thiamine-phosphate-synthase
MTALLGLAARLQMSTLCLVTDLTPRAGELVDVVVSAVAGGVDMVQIRDTDADHEALAEGVAAIADALAGSQVLLGVHGVAATVEGTRADVLHLSAEGYPGPARTALGPHGLLGRSAHDVAQLERAAADCDYLFIGPVWSGPVRRQGGLELVGRAALDCRDHDDRPIPWFAAGGITAHNVGRVLEAGARRVAVGRAVTAASDPGEVARQISRAVGRAWLDDPLTGPVQPG
>NZ_CP019400.1|WP_028701698.1|3620798_3621899_-|polyprenyl-synthetase-family-protein
MSAPFDPADPAGDSFRQAVQSAITGFLVDQRPVLAGIGEELEPLRLAAVDYTGGGKRLRPAFSYWGAVAAAGQPVDAAPLLRAVSSLELLHVSALLHDDLMDHSDTRRGVPAAHRRFGAAHERAGGSGPAGDFGADMAILLGDLLLVWSMEMFTTSGIEPLRLAATGPLLEAVRTEVTCGQVLDVTAEAGMTGGGRESGLDLANRIVEYKTARYTVARPAQIGVSLAGGTADLQQAMLTFGSPLGRAFQFRDDLLGVFGDAQVTGKPAGDDIREGKRTTLVAHAIVASTPGDARALETLLGRHDLDDADIASARRIIEASGARAGVEADIERAYRQALDALGAASMTHEGRIALTELARQCVQRSS
>NZ_CP019400.1|WP_015069982.1|3621960_3622878_+|5,10-methylenetetrahydrofolate-reductase
MLSTTSPAETIAELLTRAERPLTSFEFMPPRSEEDVYRLWRATDELVPLRPDFISVTYGANGSRRDRTLRCTQHMVASGLRTVGHLTAVSQSVAELEQTVSDYHDAGVDHILAIRGDMPGGAAEPWVARPDGLANATELVRLVKRVNPGACVGVGAFPDCHPASGDLDLDARIVAEKAEAGASFAITQLFFIPEHYTDLVARVRALGCGIPIIPGIMPITSFSQIRRFGELSGTDVPADLVARLSEVAEDRAAVREIGLEAAARLSCRLLDEGAPGLHYYTLNRSRATTELHAMVRDRRPGLWDR
>NZ_CP019400.1|WP_051143638.1|3622804_3625006_-|AAA-family-ATPase
MASEQAHVDRVYAQLRSETEAAKRLARASQEIYHSDRTTWVREEDSTAMYERDAFAYNAARRLAVLDSEHEGLVFGRIDLSDDSEVRHIGRIGVRDADYEPLVIDWRAPAAEAFYRATSTSPMGVVRRRVLRCRDDRVIGIEDDLLDSTKNRDDLPIVGEGALMAALSRARDTRMHSIVATIQSEQDEAIRAPYQGVTTISGGPGTGKTVVALHRAAFLLYSHRARLENGGVLVVGPSSVFMNYIERVLPSLGEDSVTLRAMGELASDVLGLDSDRLDESAAATLKGSLRMIDVIAALAALPLTPDPASLSLRVTIKGEVLILDAKALARTRARILRRNRYNSARQIVETSLLDQLWSKVPPETLSGYELTREDFDEAITSQASYRMFMNAWWPPMTAEQALGRLADPQVVARVATGLSAEDQKVLADSIPTSVDGGRRDWSITDIALLDELVAILGPAPVDLTAEQPVFIEGGEVSELVTVADTLADTRTVDPDDDPQDTFAHVLVDEAQDITPMQWRMLRRRGPQASWTIVGDPAQSAYPFPEETASAVAELTGHAPSRTFRLSKNYRSPAEVFDLAAGVITTVHPDADLPEAVRSTGIRPILRTSSRASLSEDLAATVRTLAGQVEGTIGIICPPSLAQVARDLAAGPLADLSGRVIPLTAMQAKGLEYDAAVVVDPDDLVAEAPGGVRVLYVALTRPTQRLVVTDLSDPTSPAGDHAPWRAALSSHGTD
>NZ_CP019400.1|WP_071162015.1|3625292_3626507_-|hypothetical-protein
MEVRGEGLIALAASLRLARLGHRVTLVAADPAWRSRARRPLSGELPPVLEVPAAWRDLFGKSGRNMDAELARDGFALTEAPPVLHRMEKETLALPTERAAQIAAVRTHWSPDVARIWSHLLDRADEAWQARRALGLEYPVAGALRGGDLPRALAGRHLTDGCDDLPALLRAVVGHLGPVAGGTRAGRGGTPLLADLAVPRVFGRWQLTRLDDGSATTLQPLLDALDRRLGARGVEVAAGPPRRPDLVIDTEPPRRRFGHDRPFLAPTVRLTRSPDTAPGGRRAERGVEHSVDHTPAGPVLRWSWSEQGQRATLTHDHTRPVRRPDLGRAIDSTAAWRRRPPLQWIRDDGAPVLAASPAAHGGPEPWAQLLTGALAAYLSHERLTGQDVSPHNRAVGADGRLRRH
>NZ_CP019400.1|WP_015069986.1|3626900_3628049_+|ABC-transporter-substrate-binding-protein
MSHDENTGPGPRPDAGDPRPDPIVLPSGAVLADDDAEERPGGVSRRALIGGVTAAAVGGLLVGGVGGGLIGRATGGPKAASTVANRPLSVIYGGDVCDAPAIVAKEKGFFAEAGLDVTLHRTVGDEDIKAAVGSGQFDASSGIFYSWLKPVSEGQNVKFVAGLHAGCLRLVAPKSFKGKVADLKGATIGIPSLSSSATMFFSMDLLDAGINPLPEAKQVNWKVLDPSTLADALKRGQVDAIATSDPIAYRPILDDYGVELSSNMSGMNAQDYCCCTALNGDLVTKEAPLARKLIEAWCRGSRYVAGHEAEVARIEVDKKYIAGDVATIEKLLKGYGWKPSVTKLRASLLPGIRKFQKTGYLEASADPEKLADKAFTTLGIRW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019400_14	14.1\|3401361\|27\|NZ_CP019400\|CRISPRCasFinder	3401361-3401387	27	NZ_CP023713	Rhodococcus ruber strain YC-YT1 plasmid unnamed2, complete sequence	16077-16103	4	0.852
NZ_CP019400_6	6.1\|1808496\|29\|NZ_CP019400\|CRISPRCasFinder	1808496-1808524	29	NC_031943	Escherichia phage vB_EcoP_GA2A, complete genome	35758-35786	5	0.828
NZ_CP019400_13	13.1\|3065360\|35\|NZ_CP019400\|CRISPRCasFinder	3065360-3065394	35	MK524530	Mycobacterium phage Pharaoh, complete genome	24249-24283	7	0.8
NZ_CP019400_8	8.1\|2399378\|34\|NZ_CP019400\|CRISPRCasFinder	2399378-2399411	34	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1256279-1256312	9	0.735
NZ_CP019400_8	8.1\|2399378\|34\|NZ_CP019400\|CRISPRCasFinder	2399378-2399411	34	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	41834-41867	9	0.735

1. spacer 14.1|3401361|27|NZ_CP019400|CRISPRCasFinder matches to NZ_CP023713 (Rhodococcus ruber strain YC-YT1 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.852

tcccgtcgggagtgggacgcggtcgcg	CRISPR spacer
tgcggtcgggagcgggacgcggtcacg	Protospacer
* * ********.***********.**

2. spacer 6.1|1808496|29|NZ_CP019400|CRISPRCasFinder matches to NC_031943 (Escherichia phage vB_EcoP_GA2A, complete genome) position: , mismatch: 5, identity: 0.828

ggagtgcccgatgaatgccagctcagaca	CRISPR spacer
gtagctcccaatgaatgacagctcagaca	Protospacer
* **. ***.******* ***********

3. spacer 13.1|3065360|35|NZ_CP019400|CRISPRCasFinder matches to MK524530 (Mycobacterium phage Pharaoh, complete genome) position: , mismatch: 7, identity: 0.8

acctcctctcccggctcatcgtggtcct--gcgacct	CRISPR spacer
acatcctctccgggctcatcgtggtccccatcaac--	Protospacer
** ******** ***************.   *.**

4. spacer 8.1|2399378|34|NZ_CP019400|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.735

tcgagcgggttgggtctgcgtccgggttcggcgt	CRISPR spacer
caggccgggtcgagtctgcgtccgggttccggtt	Protospacer
. *. *****.*.**************** *  *

5. spacer 8.1|2399378|34|NZ_CP019400|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 9, identity: 0.735

tcgagcgggttgggtctgcgtccgggttcggcgt	CRISPR spacer
caggccgggtcgagtctgcgtccgggttccggtt	Protospacer
. *. *****.*.**************** *  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2302227 : 2311123

Brucella_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_051281955.1\|2302227_2302884_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.3e-34	42.4
WP_015068914.1\|2303341_2304001_-	response regulator transcription factor	NA	NA	NA	NA
WP_095532338.1\|2304137_2304488_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_015068915.1\|2304484_2304784_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_028701325.1\|2304872_2305175_-	putative addiction module antidote protein	A0A141GEX5	Brucella_phage	2.9e-09	41.9
WP_028701326.1\|2305171_2305468_-	hypothetical protein	A0A141GEX6	Brucella_phage	5.8e-15	48.0
WP_028701327.1\|2305605_2306817_-	RtcB family protein	A0A1I9SAD2	Rhodococcus_phage	3.2e-107	51.8
WP_028701328.1\|2307366_2308809_+	MFS transporter	A0A0M3UL24	Mycobacterium_phage	4.0e-32	28.6
WP_051281943.1\|2309320_2311123_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	4.6e-30	25.7

DBSCAN-SWA_2

2536598 : 2599454

Corynebacterium_phage(16.67%)

transposase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_028701431.1\|2536598_2537345_-\|transposase	transposase	NA	NA	NA	NA
WP_060539052.1\|2538382_2539642_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	6.0e-77	43.4
WP_154662070.1\|2539788_2539950_+	hypothetical protein	NA	NA	NA	NA
WP_036937796.1\|2539922_2540591_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_154662069.1\|2540770_2541526_+	hypothetical protein	NA	NA	NA	NA
WP_154662068.1\|2541547_2541691_+	hypothetical protein	NA	NA	NA	NA
WP_028701369.1\|2541713_2543825_+	hypothetical protein	NA	NA	NA	NA
WP_028701368.1\|2543847_2544921_+	hypothetical protein	NA	NA	NA	NA
WP_154662067.1\|2544965_2545442_+	hypothetical protein	NA	NA	NA	NA
WP_051281976.1\|2545961_2546693_+	type 1 glutamine amidotransferase	NA	NA	NA	NA
WP_028701366.1\|2546665_2547415_-	hypothetical protein	NA	NA	NA	NA
WP_154662066.1\|2547435_2547594_-	hypothetical protein	NA	NA	NA	NA
WP_081685412.1\|2547625_2548693_-	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_028701364.1\|2548684_2549365_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_028701363.1\|2549382_2550114_-	hypothetical protein	NA	NA	NA	NA
WP_154662065.1\|2550339_2551110_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_028701361.1\|2551118_2552432_-	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_028701360.1\|2552428_2553835_-	hypothetical protein	NA	NA	NA	NA
WP_051281974.1\|2553907_2554495_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_081685411.1\|2554573_2557702_-	AAA family ATPase	NA	NA	NA	NA
WP_028701359.1\|2557771_2559133_-	hypothetical protein	NA	NA	NA	NA
WP_097959081.1\|2559364_2560318_-	DUF805 domain-containing protein	NA	NA	NA	NA
WP_051281968.1\|2560326_2561673_-	xylulose kinase	NA	NA	NA	NA
WP_028701356.1\|2561737_2562352_-	M23 family metallopeptidase	NA	NA	NA	NA
WP_028701355.1\|2562485_2563295_+	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_028701354.1\|2563314_2564526_-	anaerobic sulfatase maturase	NA	NA	NA	NA
WP_036937791.1\|2564621_2565032_-	DUF202 domain-containing protein	NA	NA	NA	NA
WP_028701353.1\|2565028_2565421_-	DUF202 domain-containing protein	NA	NA	NA	NA
WP_028701352.1\|2565413_2566949_-	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_028701351.1\|2566987_2568484_-	sugar porter family MFS transporter	NA	NA	NA	NA
WP_081685410.1\|2568530_2569940_-	ROK family protein	NA	NA	NA	NA
WP_028701349.1\|2570361_2571960_+\|holin	choline-sulfatase	A0A2K9L727	Tupanvirus	1.4e-22	28.7
WP_028701348.1\|2572036_2573011_-	hypothetical protein	NA	NA	NA	NA
WP_071162070.1\|2573500_2574751_-	MFS transporter	NA	NA	NA	NA
WP_051281963.1\|2574726_2575368_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_028701347.1\|2575364_2576645_-	aspartate aminotransferase family protein	NA	NA	NA	NA
WP_081685408.1\|2576646_2577942_-	phosphotransferase	NA	NA	NA	NA
WP_015069131.1\|2578229_2579537_+	mannose-6-phosphate isomerase, class I	NA	NA	NA	NA
WP_148279480.1\|2580651_2581071_-	hypothetical protein	NA	NA	NA	NA
WP_157594016.1\|2581006_2581708_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015069135.1\|2581769_2582771_+	LacI family transcriptional regulator	NA	NA	NA	NA
WP_015069136.1\|2583036_2584476_+	tagaturonate reductase	NA	NA	NA	NA
WP_028701340.1\|2584477_2585980_+	altronate dehydratase	NA	NA	NA	NA
WP_028701339.1\|2586029_2587430_+	glucuronate isomerase	NA	NA	NA	NA
WP_060539050.1\|2587552_2588878_-\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	4.5e-192	76.0
WP_015069139.1\|2588971_2589265_+	hypothetical protein	NA	NA	NA	NA
WP_015069142.1\|2589268_2589574_-	CopG family transcriptional regulator	NA	NA	NA	NA
WP_071161980.1\|2589570_2589855_-	hypothetical protein	NA	NA	NA	NA
WP_097959151.1\|2594931_2596141_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.9e-35	34.4
WP_028701541.1\|2596530_2597886_-	pyridine nucleotide-disulfide oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	6.0e-91	42.6
WP_036938199.1\|2598035_2599454_-\|transposase	IS30-like element ISPfr9 family transposase	W5R8L2	Staphylococcus_phage	1.0e-32	35.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019400

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection