CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019449	Sphingopyxis sp. QXT-31, complete genome	3 crisprs	DinG,csa3,WYL,cas3	0	1	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019449_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019449_1

3737931-3738014

Orphan

Consensus_repeat	Method
TAAATAGGGACAGTCCCTATTTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019449_1

>merge|NZ_CP019449|1|3737931-3738014|CRISPRCasFinder
TAAATAGGGACAGTCCCTATTTAATCATCCGCGCCGTTCCGGACCAGCCGATCGATGAAATTAAATAGGGACTGTCCCTATTTA

>NZ_CP019449|1|1|3737931-3738014|CRISPRCasFinder
TAAATAGGGACAGTCCCTATTTA	ATCATCCGCGCCGTTCCGGACCAGCCGATCGATGAAAT
TAAATAGGGACTGTCCCTATTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019449.1\|WP_077031667.1\|3719034_3721899_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_CP019449.1\|WP_083721019.1\|3741729_3743481_-\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|370378
NZ_CP019449.1\|WP_077031682.1\|3744543_3746832_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NZ_CP019449.1\|WP_077031679.1\|3740913_3741636_-\|acetoacetyl-CoA-reductase	unknown	unknown	gnl\|CDD\|273823
NZ_CP019449.1\|WP_077031681.1\|3743551_3744547_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_CP019449.1\|WP_077032521.1\|3747021_3747621_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019449.1\|WP_077031674.1\|3731566_3732892_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019449.1\|WP_077031675.1\|3738027_3738891_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223267
NZ_CP019449.1\|WP_077031673.1\|3730644_3731343_+\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|235919
NZ_CP019449.1\|WP_156878373.1\|3729031_3730471_+\|tryptophan-7-halogenase	unknown	unknown	gnl\|CDD\|368139
NZ_CP019449.1\|WP_083721017.1\|3733192_3737911_+\|glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|377452
NZ_CP019449.1\|WP_156878284.1\|3738922_3739186_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019449.1\|WP_077031671.1\|3726938_3728978_+\|glycoside-hydrolase-family-97-protein	unknown	unknown	gnl\|CDD\|371140
NZ_CP019449.1\|WP_077031668.1\|3721977_3723477_+\|tryptophan-7-halogenase	unknown	unknown	gnl\|CDD\|368139
NZ_CP019449.1\|WP_077031677.1\|3739516_3739753_-\|ribbon-helix-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|372613
NZ_CP019449.1\|WP_077031676.1\|3739209_3739515_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019449.1\|WP_077031669.1\|3723473_3725285_+\|alpha-amylase	unknown	unknown	gnl\|CDD\|200459
NZ_CP019449.1\|WP_083721015.1\|3725193_3726939_+\|DUF3459-domain-containing-protein	unknown	unknown	gnl\|CDD\|200469
NZ_CP019449.1\|WP_077031683.1\|3747810_3748233_-\|CoA-binding-protein	unknown	unknown	gnl\|CDD\|224745
NZ_CP019449.1\|WP_077031666.1\|3717674_3718709_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380518

Protein	Function_ID	Function_description	E-value
NZ_CP019449.1\|WP_077031667.1\|3719034_3721899_+\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	2.18791e-159
NZ_CP019449.1\|WP_083721019.1\|3741729_3743481_-\|DUF1963-domain-containing-protein	gnl\|CDD\|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	1.76287e-07
NZ_CP019449.1\|WP_077031682.1\|3744543_3746832_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	1.51263e-40
NZ_CP019449.1\|WP_077031679.1\|3740913_3741636_-\|acetoacetyl-CoA-reductase	gnl\|CDD\|273823	TIGR01829, Acetoacetyl-CoA_reductase, acetoacetyl-CoA reductase. This model represent acetoacetyl-CoA reductase, a member of the family short-chain-alcohol dehydrogenases. Note that, despite the precision implied by the enzyme name, the reaction of EC 1.1.1.36 is defined more generally as (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH. Members of this family may act in the biosynthesis of poly-beta-hydroxybutyrate (e.g. Rhizobium meliloti) and related poly-beta-hydroxyalkanoates. Note that the member of this family from Azospirillum brasilense, designated NodG, appears to lack acetoacetyl-CoA reductase activity and to act instead in the production of nodulation factor. This family is downgraded to subfamily for this NodG. Other proteins designated NodG, as from Rhizobium, belong to related but distinct protein families.	1.36322e-113
NZ_CP019449.1\|WP_077031681.1\|3743551_3744547_-\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	1.27481e-148
NZ_CP019449.1\|WP_077031675.1\|3738027_3738891_+\|hypothetical-protein	gnl\|CDD\|223267	COG0189, RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis].	8.30855e-07
NZ_CP019449.1\|WP_077031673.1\|3730644_3731343_+\|glutamine-amidotransferase	gnl\|CDD\|235919	PRK07053, PRK07053, glutamine amidotransferase; Provisional.	1.6609e-107
NZ_CP019449.1\|WP_156878373.1\|3729031_3730471_+\|tryptophan-7-halogenase	gnl\|CDD\|368139	pfam04820, Trp_halogenase, Tryptophan halogenase. Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.	3.95695e-124
NZ_CP019449.1\|WP_083721017.1\|3733192_3737911_+\|glutamate-dehydrogenase	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0
NZ_CP019449.1\|WP_077031677.1\|3739516_3739753_-\|ribbon-helix-helix-domain-containing-protein	gnl\|CDD\|372613	pfam13467, RHH_4, Ribbon-helix-helix domain. This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	3.69851e-25
NZ_CP019449.1\|WP_077031671.1\|3726938_3728978_+\|glycoside-hydrolase-family-97-protein	gnl\|CDD\|371140	pfam10566, Glyco_hydro_97, Glycoside hydrolase 97. This domain is the catalytic region of the bacterial glycosyl-hydrolase family 97. This central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, form two additional non-catalytic domains. In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands.	2.06027e-124
NZ_CP019449.1\|WP_077031668.1\|3721977_3723477_+\|tryptophan-7-halogenase	gnl\|CDD\|368139	pfam04820, Trp_halogenase, Tryptophan halogenase. Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.	0
NZ_CP019449.1\|WP_077031669.1\|3723473_3725285_+\|alpha-amylase	gnl\|CDD\|200459	cd11320, AmyAc_AmyMalt_CGTase_like, Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins. Enzymes such as amylases, cyclomaltodextrinase (CDase), and cyclodextrin glycosyltransferase (CGTase) degrade starch to smaller oligosaccharides by hydrolyzing the alpha-D-(1,4) linkages between glucose residues. In the case of CGTases, an additional cyclization reaction is catalyzed yielding mixtures of cyclic oligosaccharides which are referred to as alpha-, beta-, or gamma-cyclodextrins (CDs), consisting of six, seven, or eight glucose residues, respectively. CGTases are characterized depending on the major product of the cyclization reaction. Besides having similar catalytic site residues, amylases and CGTases contain carbohydrate binding domains that are distant from the active site and are implicated in attaching the enzyme to raw starch granules and in guiding the amylose chain into the active site. The maltogenic alpha-amylase from Bacillus is a five-domain structure, unlike most alpha-amylases, but similar to that of cyclodextrin glycosyltransferase. In addition to the A, B, and C domains, they have a domain D and a starch-binding domain E. Maltogenic amylase is an endo-acting amylase that has activity on cyclodextrins, terminally modified linear maltodextrins, and amylose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	9.66317e-78
NZ_CP019449.1\|WP_083721015.1\|3725193_3726939_+\|DUF3459-domain-containing-protein	gnl\|CDD\|200469	cd11330, AmyAc_OligoGlu, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomalto-oligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP019449.1\|WP_077031683.1\|3747810_3748233_-\|CoA-binding-protein	gnl\|CDD\|224745	COG1832, COG1832, Predicted CoA-binding protein [General function prediction only].	9.7119e-53
NZ_CP019449.1\|WP_077031666.1\|3717674_3718709_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|380518	cd06295, PBP1_CelR, ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators. This group includes the ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators. The binding of CelR to the celE promoter is inhibited specifically by cellobiose. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	8.23825e-104

>NZ_CP019449.1|WP_083721017.1|3733192_3737911_+|glutamate-dehydrogenase
MPQKIAETAEADNEAAAPAPVPAKISKAYQAALKDSALPGEGDDLDATALKDAGEFAARASLARTPGTPSLLLEPMAADGTDRRMRLAVVNDDMPFLVDSVSQIVGAQGLVIHRILHPVVAATRDAKGALTGAEAVTPGCDGRESVIYMELERGDARARRRLLDGLEGALADVRAAVTDWKAMRAAMLADAAMRVEGEGAELLRWFEGGAMTQLGHEWRTRSGDVEQPLGISASSSGQLLSPNALDAAFAWFDGGGHSPLLIKSNRLSAVHRRVLLDLVIVPEMKGKTVEKLSIHAGLWTSAALSTPPAKVPMLRAQLDALMAKFGFDPTGHAGKALAHALTALPHDLLIAFDAASLEDLVLTSMSITDRPRPKLVMVRSALGRHLFAFVWLPRDEVSTGRRIAVEAMLVREARAGVIGWTMVLEDGGAALLRYTLDLRSGGVVPDADKLNAQLEQMVRGWQPEVEAALAKRGDPGRAAALASRFAPLFPANYRNLYDPEEAARDILRLRDLDAERPRSVRLAKKSLDGDDRLRLKVYSAVGPLALSDVVPALEHFGFEVLEEIPTTLGVSRVPGAEGDDDVPAVIHDFSLKLPASVDELALLPHTEVIEGAIAAVLDGRAENDAFNELVLVTQTDPQAIVWLRAWFRYMRQGGSSYGMDTVVAALRHAPDLTAALVERFCALHDPAKHDADRAAFLDAEIQAGFAAIKSIDDDRILRLFHAVIGATLRTNAFAPAAAEALAFKIDSSKVPGLPKPLPWREVWVYSPRVEGIHLRAGPVARGGLRWSDRRDDFRTEILGLMKAQRVKNAVIVPTGAKGGFYPKALPDVALDRDAWFAEGTECYRIFIRSLLSITDNLVAGKVVHPAGVVIHDGDDPYFVVAADKGTATFSDVANALAMERDFWLGDAFASGGSKGYDHKAMGITAKGAWVSVQRHFAELGVDVQTDTIRVVGCGDMSGDVFGNGMLLSKALKLVAAFDHRHIFLDPDPDPAKSWKERERMFNLSRSSWEDYDKKLISKGGGVFPRSQKSIPLTPEVQAALGLSQAEIDPGSLISAILKAPADLLWFGGIGTYVKAASQNNAEVGDPANDALRVDAEDLRVKAVGEGANLGVTQAARIAFSAHGGRINTDFIDNSAGVDCSDNEVNIKIALNREMAEGRLSQDDRDALLVRMTDNVSALVLEDNRLQALALSIAEKGGSAAVPSLVRVMETFEAAGRLDRKVEGLAANDELLRRSAEGRGLTRPELAVLLSTSKLALQDAIEHSDLANDPALASDLAAAFPAEMQRDFAAAIADHQLRREIIATKLANRIVNRMGVVHPFELVEEEGCSLGDVAAAFVAVERLLGMHDIWASLDTAKIDEAIRLSLFAQAASAMASQIADLLRAAPGQPQPGPLVARLEPGVDRLMAGVDGLLSPSVKRQWDMLSLQLLDAGAPEALASSVVRLFKTDGAIGIVDLAERRGDDEIAVTHAFTHLGEALGLDWAQTLAAHMSPADPWERLLVNSLARDFQQMRLTFLGQLPAGDLDAAVTKWLADNGPRVAQFRATVDRARTIPNPNGAMLSHIAGQARGLLGR
>NZ_CP019449.1|WP_077031674.1|3731566_3732892_+|hypothetical-protein
MDSMRGLLSGSHGQDDGAIDSPPSVGVDERRMQVRAYNYWASLLSDRAYPSVDDLDLDHLDDFGPYAVLLDFTSGIENPGLSFLGDKLRAESQIDEDVQYIREVPGRSLLSRLTDHYLQIIANRAPIGFEAEFVNDRGTTIMYRGILLPFSSDDDTIDFIMGVINWKEAAPAAQVEELQLSVEQALRSAAPLTAPVPVWADGPDSEHIDDDPAPGFGAFADVDAALALPVEDGLDVGAELGAGAALADWLALARDTAERALAADSRSRSALYQAVGQAWDFAIAAGEAPDEFAELLADAGLKAQERAPMTPLVKLVFGANYDKTRVAEYACVLGHAREEGVGRGELARYLDSYPGGLKGLVKDERAKRRPAGVAKAKRDPVLDTLRAAQPAVILEHDAGEAEFVVLIAKAMPGGHIGIVARADDDDALLAKLARKAVVITG
>NZ_CP019449.1|WP_077031673.1|3730644_3731343_+|glutamine-amidotransferase
MTKTGLIIRHVPHEGLAGFREPIEAAGYRLDRIDVGDPGFGALDLGAPDLLIMMGGPMGVYEQAEHPWIACQLRRLARRLEAGRPTLGVCFGAQMIAAALGASVYPGPAKEVGFDALTILDPASPLGHLAGVPVLHWHGDTFDLPADVELLASSAAYPHQAFRRGPNILALQFHAEMGLDPRFEHWVDQWPEALAEVGSSPDTMRADHARLGPGAVAAGRRMIGQWLGELAG
>NZ_CP019449.1|WP_156878373.1|3729031_3730471_+|tryptophan-7-halogenase
MTACLFAKQWAGRAAITVIESPEIGIIGVGEGSTPQLKAFFDALGIAERDWMPACDATYKIGIGFEGWGGAVAPGYFHPFPAPLDVHTQSAFIRNAALRRGGVDVPAHPDAFYLAPRLAAAGQGPHPAESFPFELSYGYHFDAYKVGAFLCDHAVGLGVTHLTRKVEDVRVGSEGAVEALLLEDGEAVEGDFFVDCSGFRALIAEQALGTKFLPFADNLFNDRAVVMPTPHAEGAPLPIATGSRAMAAGWRWTIPLTTRIGNGYVYSSRYIDPEAAAIELRTALGVGDEVAARHLSMKVGRLAESWTGNCLAMGLAQGFIEPLEATALHIVIATAQEFIAAFESGGFSPKHRAVFNARIAARYEGIRDYIVAHYRMNRRADAGDYWRDAAAMETLSDDLKAMITAWFTRSDIDAVIAERGIGAYYGSISWHCLFAGYGVFPDAARMRAAAPGDGAADMAAIDDFLRRAALNFGAHRPPT
>NZ_CP019449.1|WP_077031671.1|3726938_3728978_+|glycoside-hydrolase-family-97-protein
MRIPMLFAAAAAAVPTFAQQAPAPVTAASPDGALVLTVATDNDQRPTWSLSRKGQLLIAPSKLGFILTDRIGLQRGFAIERVERASGDATWELPWGERRFVRDRHEELLVRFRQNESWGGHLMNVRFRLFDDGIGFRYELPEQPGLTTAKIADEITEFDIAPAGTAWWIPGGEWNRYEQVYQETPIEGVATAHTPMTIRLEDGTHMAFHEAALVDYAGMWLKRAEGRKFRATLSPSSRGPRVVRDLPFATPWRTIRITDNAAGLVESDLELNLNEPNKLGDTSWFKPMKYVGIWWGMIRGDWSWAEGPKHGATTERTKATIDFAAKHKFGGVLVEGWNKGWNGNWFGHGDEYSFTQATPDFDLKGVTDYARKKGVQLIGHHETGGNIAVYEAQLDEAMKLYGALGVGTVKTGYVADAGGIIAPGDAPGETRMEWHDGQRQVQHHLKVVETAAKYKVAVNPHEPVKDTGLRRTYPNWVAREGARGMEYNAWGRFANGPEHEPTLVYTRMLSGPMDFTPGVLSLEGANHDPLASTLAKQLGLYLAIYSPIQMAADFPETLAKFPRELDFISKVPADWAESKLIAGAVGDYAIFARKDRASADWYVGGVNDATARTLDLAFDFLEPGKTYTATIYKDGEGATYLTDARHRIAYETIKVKKGDTYKLWLAPGGGAAIRLVPGK
>NZ_CP019449.1|WP_083721015.1|3725193_3726939_+|DUF3459-domain-containing-protein
MASVRRRLRRRAACPFPSPPSARSSARPANKRRQVTTNQSLPKPDFAPAPGAALPWWKGAAIYQIYPRSFADSNGDGIGDLAGITARLDYVASLGVDAIWLSPFYPSPMEDFGYDVADYCDVDPIFGTLADFDALVAKAHGLGLKVTTDLVFAHTSDRHAWFAESRASRTNAKADWYVWADARDDGSPPTNWQSVFGGPAWTWDARRGQYYMHNFLSSQPQLNVHNRDVQDALLDAVRFWLDRGVDGFRIDAINFAMHDPLLRDNPPAPPSNKPRTRPFDFQQKIYNQSHPDIALFLERIRALTDQYEGAFTVAEVGGEEAEREMKLFTAGERRLNSAYGFNFLYADALTPRLVREAAEQWPDAPGIGWPSWAFENHDAPRALSRWAVEGVDASAYAAMKMALLCALRGNIILYNGEELGLGQVDIPLELVKDPEALKNWPLTLSRDGARTPLPWVAGARHAGFSDGDPWLPLGEAHDALAVDRQEADAGSMLALTRRLLALRAASPALRLGANARWVVQGDLLGFDRIGEGQHLRCLFNLGAGTIDVATESGRILLALNGAEPDKLPPAGVLWLEMEETK
>NZ_CP019449.1|WP_077031669.1|3723473_3725285_+|alpha-amylase
MIRRLALLALLLAPLPAAAEDSDIAAVRARAPTDELVYFVLPDRFENGDAKNDKGGLKGDRLATGYDPSAKGFYHGGDLAGLTKRLDYIAGLGASAIWFAPVFKNKPVQGPKGDESAGYHGYWVTDFTQVDPHFGTNAEFKAFVDAAHKRGMKVYMDIITNHTADVIRYAEGEAEGYKYRSLADYPYSRRGGVSGAPINPGFAGEHDASAENWAKLTDPDFAYTPVVPKGEEKVKVPAWLNDPIHYHNRGNSDWVGESSLYGDFAGLDDLATESPKVVQGFVDIYGRWIDEFGIDGFRIDTAKHVNPEFWQAFVPAMQARAKAKGIPNFHIFGEVYIDAVDPGGLAWHTHAAGLPAVLDFAFARATIDAVSGTKGTADFARLFDGDLLYKGGANAALELPTFLGNHDMGRFAMFVKQANPGASEAELLARVKLGHSMLLALRGVPVIYYGDEQGFVSDGNDQLAREDMFASQVAVYNDNDLIGSDATTAAANFDTGHPLYRHIAELAAVRRASPALSRGATKLRAFSEKPGLFALSRFDPDSGRETVVAFNTSAEPVTANIAIDMKSAGFTALHGECPAAPAAPGSLPLSLPAFGTIICQASE
>NZ_CP019449.1|WP_077031668.1|3721977_3723477_+|tryptophan-7-halogenase
MTPMRLIIIGGGTAGWMAAACLRRFLPQGWSVTLVESEAIGTVGVGEATIPQIRLFNEALGIDEDAFLRATQGTIKQGIEFDGWTRPGHRYMHAFGAIGRGLGLLPFHQYWLRGRSLGIADSLDAYSLNEQAAHAGRFRRGAGGSAHAPAMPYAFHFDAGLYAAFLRKRAEGWGVTRVEGKVVSAERADNGDVAAVLLEGERRVAGELFVDCSGFRGLLIEGALATGYEDWSHWLPNDRAVAVPCGHGDTPQQPYTRAVAREAGWQWRIPLQHRIGNGYVYCSRFLDDDAAEAALLASLDGPAQAPPNRLRFTSGKRRKMWNRNVVALGLAAGFMEPLESTSIHLVQSGISRLLNLLPAGAPDPAIVAEFNQQSDFEWERIRDFIVLHYKATERADTPYWRERAAMDIPDTLAAKLDQFRAQGLIVREHEELFTEPGWLQVLVGQGVMPTAWHPLADTLSEADLKTFLDTNRLVIEREVAAMQPYDAFLNSMSPTGVAA
>NZ_CP019449.1|WP_077031667.1|3719034_3721899_+|TonB-dependent-receptor
MSKPTNRHPQLRRGASVLALGLAMSVFAPHAFAQDSAPVADDAGEDEIVVTGYGASLQSAVNAKKTRDQIVESVSAEDIGKLPDASIAEAIARLPGLTSQRVSGRSNAISIRGFAPDFSTTLLNGREQTSTGDNRAVEYDQYPSEVVNQVLVYKTPMASIVGQGLSGTVDLRTIRPLDYGKRVFSIGGRGTWADLGKLNVGSKKYGYRVNGVFVDQFANDTLGIALSASYVDEPYQIQEFNAWGYAGGGTAASPVVIGGSKSYATSTQLTRLGLQGTVQWRPHPNFTSTFDAFYSDFSDDQIKRGIELPLGFEGSVGVNVTDVDSSGEFVFARAGTFTNVEGVVRNDVFERNAKLYSFGWNNKWEGDDGWNVTADISLSKTDRNELILESNAGTGRGAGVGARDTIGFTSDINGTVFSPTLNYGDYNLIKLTSPLGWGGNQTGVNGDRIQGGQDGYYNNRIIEDELWQYRVEVERELDGFLKSVQFGVNYTDRKKSLTPDEAFVGLVANTDGLTSVTIPEEFRRGTTNLSYLGLGPVVSYDPRDLLAAGIYRLVPNPYGDVVVKAYDVSEKLMTTYLQANIDQEMGSSALTGNIGVQAIFTDQNSNGASGSFIGTNPNGSPNIQGIPQRRSTDYLDVLPSLNLSLRTDSDFVIRLGLAREIIRPRLDDMRASLSYGTTIGDPGGIVCPAGRTCAVVRGDAGNPDLRPWRANAADLTFEKYFGGSGYVAVQLFYKQLKSYIYNQAIPFDFTGYPIQAPGNDSGDTDGDGFPNRDPLPIIVNYMGTINAPINGEGGKLYGAEFAATLPFSTFTSALDGFGLTGSASYTKTNIQPTPGAPSEDIPGYSKWVANGTAYFEKWGFNARASARYRSSFIGELSGFGGNRVRRRARAETIIDAQIGYDFQPGSALEGLSVFVQGQNLTDEPFVTDDPRDSRAVIDYQTYGRRFLAGASFKF
>NZ_CP019449.1|WP_077031666.1|3717674_3718709_-|LacI-family-transcriptional-regulator
MGRPPSAKPTSFDIAYLAGVSQPTVSRALRGSKSVSAATRANIERIARELNYTVDKNASSLRSQRTHTLALLFFEDPTPDQSMINPFFLSMLGSITRQCALRGYDLLISFQQMHNDWHVAYQDSHRSDGIILLGYGDYQTYRSKLEHLVEMDTKFVRWGSVSDDSIGLTVGSDNIGAGVQAGEHLVAIGRRAIAFLGDASDHAPEFQDRYTGLCRAMAAAGLTPNPALQQDAVSSEESGYAAAQALLAGGKSFDAIFAASDLIAIGAMRALTEAGLKLPHDVAIIGFDDIPAASQTSPTLTTVMQDLKGAGELLVDALLARIDDVAVERSVLPTRLIKRQSTAV
>NZ_CP019449.1|WP_077031675.1|3738027_3738891_+|hypothetical-protein
MPYQPRVAILVPGAEYYEKWQPAFARKALALAGAGLAVEQRVWGDPGDLKGFDLILPLFAWGYQRDVPRWYALLDRLEAEELPVVNPVAVLRWNSDKAYLSQLAAKGVAVVPTVEIAALDDAGLADARARLGADEVVIKPAISGGADGTHRVAAGVGVPPDAVGQRRLVQPLMPGILTEGEYSLFFFDGQFSHAIVKRPAAGDFRVQEQFGGRETAWDASAEAQALAAAALAAAPAPPVYARVDMVGDAAGVLHIMELELIEPSLFLHFAEDKGAAFGKAVAGVAVR
>NZ_CP019449.1|WP_156878284.1|3738922_3739186_-|hypothetical-protein
MTQVRCPVGHQFSDTLAPSPCRSTLIPDEEIERLAQRIVEQVRHDDFEVVVGYLISTSGLDAYVCPHCDRFFTVDESNALVASYLKE
>NZ_CP019449.1|WP_077031676.1|3739209_3739515_-|hypothetical-protein
MAWNPFRRKGKLAPIDREATRHVIANRNSFPIYVSVEPWPECFELEPEESLTLVVGDAEAAIEVQVIDERELVIYPASVDIDFLIDGKPAEDRSWQFRHER
>NZ_CP019449.1|WP_077031677.1|3739516_3739753_-|ribbon-helix-helix-domain-containing-protein
MAAPYHPPVKRSVTIAGHPTSISLEPVFWDALEAEAARQALPINALVARIDVERMEAEDPPNLTSAIRQWLWRGRTEE
>NZ_CP019449.1|WP_077031679.1|3740913_3741636_-|acetoacetyl-CoA-reductase
MARVAIVTGGSRGIGEAISLKLQEQGVTVVANYAGNDDKARAFTERTGIAARKWDVGDHQACLDQCAAIAEEFGPIDIVVNNAGITRDGTLARMSYGDWDDVMRVNLGGCFNMAKATFGGMVERGWGRIVNIGSINGQAGQYGQVNYAAAKSGIHGFTKALAQEGAKKGVTVNAIAPGYIDTDMVAAVPAPVLEKIVAKIPVGRLGQADEIARGVAFLCSEDAGFVTGSTMSINGGQHMY
>NZ_CP019449.1|WP_083721019.1|3741729_3743481_-|DUF1963-domain-containing-protein
MSQVQSAMLMLGGGTLAYLLIVYFVWRRRGPVAPKAPKAPRVPGAPRESRLPSLPRRDRARERIAEEPVEISASRLARVSGRAPLEPATESAFDASVEAPAAAHADVLVDERDPLPPVPAEPTEADRAMVTQMLESMVAQVEHEADLIERRGTEPVAVRLAPQIPPRTDEARTSWLGGRPRLDPGAAWPQIREVPGQFIAQIACADLPAGIWDGLGPRRGSLALFIHPRDGDAALVHVHEAGEPVEPPHPLDPGGSFFAPHGGLRFGDLMPFARAAFPEWPVDLVAVRPGDADPRQADGEDGDGPGFRLYRLGYDIADPAFHPFDWPSMLAMVEILAMRIERYWKEVEGPSPIDTQLASVERRLVKHDDGEKDPLGREGLVNMRAALQELHDAAAAARAANHVARFRAEEIIDIVRESATRMAFTATDAAAVMEALQAITWVKVLRKPDPAGRPGAELIESLTLPLTQHHPDAPLWVHDYHSIWFDHAKHAYAADPDALSDAARAVFEPYAQELAAREMPSIGHIPFRYVHDYDEESHATLLELPTSGLMSWMFGDVDHLVLTMRKADLAAGRWDRPIVQVSN
>NZ_CP019449.1|WP_077031681.1|3743551_3744547_-|ferrochelatase
MTRPADHPTIAPPRVGVLLVNLGTPDAPDARSVRRYLAEFLSDRRVVEIPQILWQPILRGIILTTRPKKSAHAYSQVWTEEGSPLAAITRRQAAALQAALGEGVRVEHAMRYGRPAIPATLDAMFAAGCRRILVAPLYPQYCGATTATVTDAVNAHLATLRWQPALRFLPPYADDTHYIAALNASVETGLAALDFAPDVLLASFHGMPERTLHLGDPYHCQCRKTARLLSEALGRPVEVAFQSRFGRAKWLEPATDAVLERLGSEGKKVAIFAPGFAADCLETLEELAIRGKEQYEAAGGTDFAYIPCLNDSAPGLAMLEALIRRELAGWA
>NZ_CP019449.1|WP_077031682.1|3744543_3746832_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MAGIRDSIDTKKRRLPHISRRSLLVGATAAGGLALAWSIWPRDYAPNLTAAPDEHIFNAFLKIGDDGHVSVIVPQCEMGQGVTTLLPQIIADELGADWRTIAVETAPISPLYTNTLLVDEDSATFTPRSMMPDAVADVRSWARREWAVRHAVMLTANSSSVRMFERPCRDAAAQARALLMMAAARRWDADWQQCDTANGFVTLGAKKLRFAEVAAAAALLEPPAAPVYRAASADPLYGQDLIRLDLPAKVDGSANYAGDIRLPDMVFASIRQGPLGATRLKSIDKKAGLASPGMLYVVEQEHWVAAVARNWWAANRALDKFAPVFETAGPPIGSDGIDKALKAALKADGHRIVKRGDPSEAMEGRASIGATYAVAPALHAPIETRTATAAPDGARLRVWTATQAPAQCRAAIAAATGLSENDITLFPMMAGGSFDACLNHDVAVQAALIARTIKRPVQLAWSRAEEIMRDIPRPPARARMVATLNAAGGIDALVARIAVPPTTHEVRERLFEHKAPDAAQRAAAGASDAAAVEGAANGYAIPHLAVDHCPADIGLPTGRWRGNADSYTAFFTESFVDEMAAKAGLDALSYRMAMLGQQPLLARCLLTATSIGGWEGMLSGSGQGLACHSMRGSHIALMATARPSGEGLQVEQLVAVVDAGRLVNPAIARQQVEGGLIFGLAAAVGATTDYKGGVATARKLGQLGLPRLAQSPEIVVEFVESDRDPGGLGEIGVPVVAPAIANALYAATGRRIRRIPLSPERA
>NZ_CP019449.1|WP_077032521.1|3747021_3747621_-|hypothetical-protein
MKRTLALLAAATLAGCAATPAPSNPQEAFFAALTARCGQAYAGRIETNDAADADMQGKAMVMHIRRCTADRIEIPFHIEGLGPKGGWDRSRTWVVTRTETGLRLKHDHRHADGTSDEVTMYGGDTADEGTATRQAFPVDAESIALFTRTGRSVSNTNVWAMEATPLGFAYELRREGRHFRVGFSWNRPVSPPPPAPWGW
>NZ_CP019449.1|WP_077031683.1|3747810_3748233_-|CoA-binding-protein
MAINDDSDIRELLGQPRRIAVVGASPNPARDSNHVLAFLVAQGHDVIAVNPGHAGSTIHGAPVVANLANVEPPAEIVDIFRNSEDAGAAVDEAIVHGAKAVWLQLGVINDAAAKRAEAAGLTVVMDRCPAIEIPRLGLRR

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Crispr_ID: NZ_CP019449_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019449_2

3890895-3891084

Orphan

Consensus_repeat	Method
GCCTATGTCCGCGAGATGCGCA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP019449_2

>merge|NZ_CP019449|2|3890895-3891084|PILER-CR
GCCTATGTCGGCGAGATGCGCCGCCTGTTCCCCGGCGCCGACCTGGGCGAGTTCATCGGCGCTCACGCGGTCGGCATCGACCCGGCCTATGTCCGCGAGATGCGCACCTATTTCCCGCGCGTCGATATCGACGAGTTGACCGGCATGCGGGCGATGGGGGTCGACGGCGCCTATATCCGCGAGATGCGCA

>NZ_CP019449|2|1|3890895-3891084|PILER-CR
GCCTATGTCGGCGAGATGCGCC	GCCTGTTCCCCGGCGCCGACCTGGGCGAGTTCATCGGCGCTCACGCGGTCGGCATCGACCCG
GCCTATGTCCGCGAGATGCGCA	CCTATTTCCCGCGCGTCGATATCGACGAGTTGACCGGCATGCGGGCGATGGGGGTCGACGGC
GCCTATATCCGCGAGATGCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019449.1\|WP_077031797.1\|3899404_3900949_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP019449.1\|WP_077031782.1\|3878629_3879568_-\|DUF979-domain-containing-protein	unknown	unknown	gnl\|CDD\|377620
NZ_CP019449.1\|WP_077031788.1\|3887470_3888442_-\|magnesium-and-cobalt-transport-protein-CorA	unknown	unknown	gnl\|CDD\|213364
NZ_CP019449.1\|WP_077031785.1\|3884021_3885668_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226434
NZ_CP019449.1\|WP_077031786.1\|3885839_3886487_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NZ_CP019449.1\|WP_058810692.1\|3889221_3889599_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP019449.1\|WP_077031792.1\|3894533_3894917_+\|reverse-transcriptase-like-protein	unknown	unknown	gnl\|CDD\|260011
NZ_CP019449.1\|WP_077031796.1\|3898246_3899395_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273385
NZ_CP019449.1\|WP_156878295.1\|3886366_3887053_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176856
NZ_CP019449.1\|WP_077031799.1\|3901636_3902662_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NZ_CP019449.1\|WP_077031791.1\|3891434_3892241_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019449.1\|WP_077031784.1\|3880441_3884035_-\|5-oxoprolinase	unknown	unknown	gnl\|CDD\|215358
NZ_CP019449.1\|WP_077032543.1\|3892255_3894343_+\|TonB-dependent-receptor-plug-domain-containing-protein	unknown	unknown	gnl\|CDD\|238657
NZ_CP019449.1\|WP_083721054.1\|3896094_3896772_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379522
NZ_CP019449.1\|WP_077031789.1\|3888452_3888893_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377950
NZ_CP019449.1\|WP_077031783.1\|3879564_3880239_-\|DUF969-domain-containing-protein	unknown	unknown	gnl\|CDD\|368767
NZ_CP019449.1\|WP_077031781.1\|3877479_3878469_-\|DUF2891-domain-containing-protein	unknown	unknown	gnl\|CDD\|378592
NZ_CP019449.1\|WP_077031795.1\|3896825_3898247_+\|efflux-transporter-outer-membrane-subunit	unknown	unknown	gnl\|CDD\|273830
NZ_CP019449.1\|WP_156878376.1\|3901041_3901473_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182070
NZ_CP019449.1\|WP_077031793.1\|3895081_3896122_+\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562

Protein	Function_ID	Function_description	E-value
NZ_CP019449.1\|WP_077031797.1\|3899404_3900949_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.51501e-124
NZ_CP019449.1\|WP_077031782.1\|3878629_3879568_-\|DUF979-domain-containing-protein	gnl\|CDD\|377620	pfam06166, DUF979, Protein of unknown function (DUF979). This family consists of several putative bacterial membrane proteins. The function of this family is unclear.	1.10962e-128
NZ_CP019449.1\|WP_077031788.1\|3887470_3888442_-\|magnesium-and-cobalt-transport-protein-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	9.6347e-137
NZ_CP019449.1\|WP_077031785.1\|3884021_3885668_-\|histidine-kinase	gnl\|CDD\|226434	COG3920, COG3920, Signal transduction histidine kinase [Signal transduction mechanisms].	1.62873e-34
NZ_CP019449.1\|WP_077031786.1\|3885839_3886487_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	8.09586e-41
NZ_CP019449.1\|WP_058810692.1\|3889221_3889599_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	1.07513e-22
NZ_CP019449.1\|WP_077031792.1\|3894533_3894917_+\|reverse-transcriptase-like-protein	gnl\|CDD\|260011	cd09279, RNase_HI_like, RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII); however, a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif, they lack other common features important for catalytic function, such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.	1.68969e-13
NZ_CP019449.1\|WP_077031796.1\|3898246_3899395_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273385	TIGR00998, Probable_multidrug_resistance_protein_EmrK, efflux pump membrane protein (multidrug resistance protein A). [Transport and binding proteins, Other].	1.23652e-101
NZ_CP019449.1\|WP_077031799.1\|3901636_3902662_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	1.34733e-161
NZ_CP019449.1\|WP_156878295.1\|3886366_3887053_+\|hypothetical-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	4.3615e-11
NZ_CP019449.1\|WP_077031784.1\|3880441_3884035_-\|5-oxoprolinase	gnl\|CDD\|215358	PLN02666, PLN02666, 5-oxoprolinase.	0
NZ_CP019449.1\|WP_077032543.1\|3892255_3894343_+\|TonB-dependent-receptor-plug-domain-containing-protein	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	4.73023e-22
NZ_CP019449.1\|WP_083721054.1\|3896094_3896772_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379522	pfam14246, TetR_C_7, AefR-like transcriptional repressor, C-terminal region. This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.	5.25304e-31
NZ_CP019449.1\|WP_077031789.1\|3888452_3888893_-\|hypothetical-protein	gnl\|CDD\|377950	pfam07971, Glyco_hydro_92, Glycosyl hydrolase family 92. Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation.	1.00709e-22
NZ_CP019449.1\|WP_077031783.1\|3879564_3880239_-\|DUF969-domain-containing-protein	gnl\|CDD\|368767	pfam06149, DUF969, Protein of unknown function (DUF969). Family of uncharacterized bacterial membrane proteins.	1.54253e-109
NZ_CP019449.1\|WP_077031781.1\|3877479_3878469_-\|DUF2891-domain-containing-protein	gnl\|CDD\|378592	pfam11199, DUF2891, Protein of unknown function (DUF2891). This is a bacterial family of uncharacterized proteins.	1.32919e-162
NZ_CP019449.1\|WP_077031795.1\|3896825_3898247_+\|efflux-transporter-outer-membrane-subunit	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	1.53636e-94
NZ_CP019449.1\|WP_156878376.1\|3901041_3901473_+\|hypothetical-protein	gnl\|CDD\|182070	PRK09776, PRK09776, putative diguanylate cyclase; Provisional.	0.00615918
NZ_CP019449.1\|WP_077031793.1\|3895081_3896122_+\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0

>NZ_CP019449.1|WP_058810692.1|3889221_3889599_+|MarR-family-transcriptional-regulator
MLTSLPPREREIVDILYERGASTVTEIADALADELSGSAIRAMLKRLEGKGFVAREASDRGFVYAPSVPEKAASKSALSQVVRVFFNGSPTSAAAALLGMQGEMSNSELDELEKLIADAREGKAK
>NZ_CP019449.1|WP_077031789.1|3888452_3888893_-|hypothetical-protein
MNRLSFAAALVAAAFAIPTSAEEPAPDVLTYVDPTIGIGPEGHTFPAGQKAHLLLDLYVIGRPFVDRAVLNLPDGKKFTVETLGLSDANPYVGKVELNGKALTRGWIADAGIRKGGTLRFTMQSTPNAEWGKAATARPYSMSTAGQ
>NZ_CP019449.1|WP_077031788.1|3887470_3888442_-|magnesium-and-cobalt-transport-protein-CorA
MPIMAARHYNNGKLVRDLGPDEIIPEDCDDRDFYWLGLYEPTAGELAGIAKRFGLHPLAVEDALKAKQLPKVEVYGDQLFVIAATGNREGDTIQSGETAIFVGRHFIVTVRHGSARAHTDVRARLETLPAKLSHGPDYVLYAILDFIVDGYFPVIDDIEDRLLLVEESVMDTPLDAKEIRHLYAQRHEIIRFQRIVGLMKEVAWRLVHAEDLPWIDEAVRPYFRDIWDHVQRAEFRLSGLREITASVVETNSLLEQQRQGVITRQLAAWAAILAVPTAIAGIYGMNFDFMPELGWDLGYPYALGLIFGGSALVFWRFKHIGWL
>NZ_CP019449.1|WP_156878295.1|3886366_3887053_+|hypothetical-protein
MRRRGDAPEGRCMERSDIGAAELCTLGRKRRADDGEGARLMRAWVLAAALSIAVPAAAQADTVVVTKTVEADATTTMKHEVLVDASPAEVWAAISTAEGWMGWAVPVARTVGGDPDLIESGYDPAAKPGGSDTIQQRFGARVPGRSLAFRTVKAPAGFPHWDEYQKVTSVFEIEAAGKQTRVRLTSRGYPGSDGGRALVGFFEGGNAMALGNLRQRFATGPIDWAAMR
>NZ_CP019449.1|WP_077031786.1|3885839_3886487_+|glutathione-S-transferase-family-protein
MIIYGSLVSPFVRKLLAYLGEKGLDFELKGVGIGDPDPGFRAASPLGKMPAMDDDGFMLADSSAIVQYLEAKHPSPELIPADPQQRGKVIWWEEFGDTVFAACSGKMFFNRIVAPKFLGREGDLAAAALAESEELPKLLAYLESAIPASGFLVGDRITLADLAVASPLMNFKHCGACVDAATHPKVAAWSAAILARPSFAPWVEKEERMMAKVLA
>NZ_CP019449.1|WP_077031785.1|3884021_3885668_-|histidine-kinase
MGSMWADRLMALSVRVIGFVIVAAALAGAAGSFLYNQAQEADQAARVALQMNTRLRDHVGVLEGVRAMYQSDTAASGPGIRAYLAALRPQEQAPGMEGVGIAAAMRRDDPATAEVQLRANYGRDIEVWPRTSSQKVGFTVVLVEPYTPRRNAALGFDMYSEKTRREAMRRAWQTGRPAASGIVQLAQERAAQVKQPGFLIYIPVYARRAIAAPMLPPGGPPSETDAPVVATLPGQRPVEAFIYAPFRTDDMMRAILGDQLDTLDGVEVRAGEGPSAPLVFRHGTLGWDAHEQKLRVADREWTIRISYGRFLDRLGRPLGIFLFGVALALLAMQIHRLQHRRLDVAQALADEQKRHAEDRELMIGEMAHRMKNAFARIGALARITIRESADLEEFEAKFDGRMRALSDAKQMLVTGAVDLFDLGRIVRRELDLAGRGSDDISGPDVRLDDEAAQALSLALHEFVTNSIKYGALAGKGDLKVGWRRVEGDIELSWIESNLPETPAIDGESFGTQFIRTLIERQLKGSWSRAATDHGLAITIRWPDRDVGA
>NZ_CP019449.1|WP_077031784.1|3880441_3884035_-|5-oxoprolinase
MSAHNDTRWQIWIDRGGTFTDVVARSPEGHVVTTKYLSEDPARPGDAAVNAIRDLTGAGAGALPPLAIRMGSTVATNALLERKGEPTLLAITRGFGDALTIGYQDRPELFARKLDRTPPPHAAVAEIAERVGPEGELLTPLDEAPARAALQAARDRGLTSIAIVLMHGYRYPEHERRLAAIAAELGFTQISTSHDVSALIKLVGRGDTTLADAYLSPVLRHYVDQFVAQLGDGIDPQFMKSSGGLASASAFHGRDAILSGPAGGIVGMVGSAAPLGKTRLIGFDMGGTSTDVSHYAGRLERDNEGVVAGTRIRAPMLRIHTVAAGGGSICRWDGTRLLVGPESAGANPGPAAYGRGGPLTVTDCNVLLGKIQMGHFPKLFGPNGDQRLDREVVVRKFATMAAEVGISPKALAEGLLAIAVQQMANAIKRITIARGHDLTQGYSLVGFGGAAGQHVCLVADALGIDEILLHPLAGVLSAYGMGLAKPSSIRERTLALKLDAHCAGTLAAAEAELSEQARTDLAPGVGTTRETLLFVRLADSDNAIELPLAPPAEVATAFAAAFRQRFGYAPHANLVVDRIRVELTETSEATASLPPPAATEEAPPETVTAWLAGAAHDIPLHQRRALAPGRSIAGPAIVIDTLATTVVEPGWTAEVQHEGTLLLARTRAAATHATASEDLAAPNPIRLEIFNSLFMAIAEEMGGALRHSASSINIRERLDFSCALFDGTGSLVANAPHMPVHLGSMGESVRTILRQRTRDGRGIKRGDAYALNAPYDGGTHLPDITVIMPVFVEGNTPSFFVAARGHHADLGGIAPGSMPPDSKSIADEGILFDNVLIVDNGNFLDANVHAHLTSSEWPARNPALNIADLKAQVAACQRGASALADLSATHGVQTVAAYMAHGQRQAEAAVRQLIARLDDGQFRYAMDNGAEVAVAVQVDRKARHVTIDFTGSSATLPDNFNAPAPVVRAAVLYVLRTMLDDPIPMNEGCLAPVTLIIPEDSMLSPRYPAAVVAGNVETSQVITDALFAAFCAMAPSQGTMNNFTFGNTAHQYYETIAGGSGAGPGFDGTGVIQTHMTNSRMTDPEVMEMRFPVIVEDFSIRKGSGGGGRWHGGDGATRRIRFREPMAANILANRRKIAPAGLAGGNDAAPGCNWVERADGSIEMLGATGSADLAAGDAFVIETPGGGGYGKTQGNNN
>NZ_CP019449.1|WP_077031783.1|3879564_3880239_-|DUF969-domain-containing-protein
MLVLIGILIIIAGFLLRFNPLLVIMASALATGLAAGLDIAAIIAAFGKAFNDTRYVSIIWIVLPVIGLLEAYGLQQHARNIIGRMRGATLGRLLTGYLFLRQAFAAVGLTSVAGHAQTVRPLVAPMAEAAAEAQSPALSDDEREEVKAYAAATDNVGVFFGEDIFLAFGSILLMRGILEGYGYDIEPLHLSLWAIPTAIAAFLIHGFRLRRLDKRIRPTGERGA
>NZ_CP019449.1|WP_077031782.1|3878629_3879568_-|DUF979-domain-containing-protein
MITLGHVYLLAGIVFALFALLGLYDRSNPKRFGNAAFWGLVATAMMAGDYLGDFGNGLLVLALVAIAGTGQIGRAPGGEVPAEVQAERAARYGNFLLLVALIIPAVALIGTFLFKEIPGLADPKQATLISLAIGVLIALAVGMARLKPPALLPLQQGRRLLDSVGWAAILPQMLASLGAVFALAGVGDVVGGLIGTAIPQGSLFGAVLAFGLGMALFTMVMGNAFAAFPVMLAAVGMPLLIKQHGGDPAVVAAIGMLAGFCGTLMTPMAANFNLVPAALLELKNPYGVIKAQIGTAVPLLAVNIVFIWLFAF
>NZ_CP019449.1|WP_077031781.1|3877479_3878469_-|DUF2891-domain-containing-protein
MHLNPDHAARFATATLSHLGREYPYKMDLVLLGPEDAQPPREHHPIFHGSFDWHSCVHGWWQILRLARRFPDLPISADIRARADAMLVPEKAAGELAFLDRPYSAAFERPYGWAWLLALHAEAEEHEAPWAKALEPLALAFAGRFHAFLPKLTYPLRVGTHFNIAFALLLARHWAETRDPALVTLIDTSARRWFADDRDCQAWEPGGDEFLSSALSEGHLMAAVLGTDFTRWFDAFLPRAAKEQPVTLFTPATVSDRSDGKIAHLDGLNLSRAWNWRMIAATLGPAHPVAPVAEAAAERHLAAALPHVTGDYMGEHWLASFALLALDGL
>NZ_CP019449.1|WP_077031791.1|3891434_3892241_+|hypothetical-protein
MKTLNFASSLAVLSVLACTTPSQPATAAAQESGAENGDMRWSVEPDGGKDRAPKLRLSHRRTTSDLSLDADLGVKRPEFGAAQSALGGSGPVRFSVRHESGTLECSGTLAQSYDGEGRCSFTPDAAFERALASRGLAPDKRGDLFAMLIVDATIELADGLTAEGVKPGDWDDLVAAAALEVTPAFVRGFKGTSLQLSDVRDLNAAGFAKLGIDDVTGMKALGVTGDYVRELRTAGYDKLSAEDVIGMKAMGVTGDYARRMNGAAGGTR
>NZ_CP019449.1|WP_077032543.1|3892255_3894343_+|TonB-dependent-receptor-plug-domain-containing-protein
MGTSLAAVAAVLTSVPAAAQDAPTGDTPPPAPTEAPVGGQQTQGQVYSPADFARYAPNNAYDMLIQVPGFSIRDNENLRGLGVATGNVLFNGERPSNKADDMYTQLSRIPAGNVERIEIVDGASLDIPGLSGQVANIVYRADNFSGQFSWKPQFRAHYTDPLFTRGDVSVRGRKGEIEYEAALSNDDSARSGAGGPTIITDGAGNIIERRRDVWNTHYDTPKLSGRITWDPAGDTVANFGGHYQRKYDRYYEDGVRTGPGLVDRFRTVRDKADSWNYELSGDYQFGFGPGKLKLIGLRRFSHEPYSSEVISTPDDGSPATGDRFAQVGDLGETIARGEYQWKMWGGDWQLSGEAAFNTLDNIASTGELQPDGTFDKTPFVPGTGGVSEDRYEGLLSFGRKITDTFSFQLVAGAEHSTIVQAGPDGVSRSFARPKGSLTLSWKPSDDFDASLKIRRRVLQLSFYDFLGRAFLNDGNQNETNFDLRPQQDWSFEAEINKKLGAWGSTKIILIHRDVEDRVDIVPVGNGEAVGNIPKAKASAIDWTATINLDPAGIKGMKLEPRLLLQTSSLRDPFTGEKRQWSGFTDTVASIGLRHDIPGSDIAWGANAEYAHYQPNYRRNQVDKVWEGPVWASVFVEHKDVMGLTIRASINNIVNARSRRDRTVYTGVRGESPVAFVEDRNRLIGPIFSFSVRGTF
>NZ_CP019449.1|WP_077031792.1|3894533_3894917_+|reverse-transcriptase-like-protein
MTTRRTKIYFDGGARPNPGAMEIATVCRGVVHVERDLGVGTSLDAEWLALIAALRLARAQGLEDVLLLGDAAAVVAQANGAAPARGRAAQHFAVFRALVGEGTAPRVRHVGRAQNLAGIALARLHPR
>NZ_CP019449.1|WP_077031793.1|3895081_3896122_+|rod-shape-determining-protein
MQFFRRLTSSAHDMAIDLGTVNTVVYVRDRGIVLNEPSVVALETRDGVRRVKVVGNEAKLMMGKTPDNIQAIRPLRDGVIADIGVAEQMLSHFIEKALGGPSRFRRRSHVVICVPAGSTMVERRAIRDAASNAGAVSVRLIEESLAAAIGAGLPVTAPQGAMVVDIGGGTTEVAVLSLGGIAYSTSVRVGGDKMDEMIASYIRRKHNLMIGEMTAERVKLLLGCATPPEGTGLVMGVKGRDLVNGRPSEVQVTEAEVAEALIEPVGQIVGAVRAALEATPPELSADIIDGGIVLTGGGALLRRMDEAIASATGLHVMVADDALMCVAMGAGRAAEDPAYEGVLISA
>NZ_CP019449.1|WP_083721054.1|3896094_3896772_-|TetR/AcrR-family-transcriptional-regulator
MSIEMIPDSTASLDEAAAARRKAFVDAARILFFANGYSGTTMSSIAATVGGSKTTLWTYFPSKEELFAAVVDDIVGEYGSALHVDLPVDQPVTEVLTRFGNVLMTTLISTPLLSLFRLVVGEAERFPHLAETFYDRGPRRGKARAADWVAAKMERGELRQGEPMQAVRHFAGLCQSGLYQHAVLGLPEGRDTSRMAAEVDAAVDTFYRAWGAAPAADQAEISTPS
>NZ_CP019449.1|WP_077031795.1|3896825_3898247_+|efflux-transporter-outer-membrane-subunit
MLSRFFLSTALLGLLAGCVGTPDVGPKPVPVAAESLESRTSFADAKGSWPAEGWWRAMGDAQLSALIDEGLAGSPDVAIAAARVRAADALAQQARAALGPRVGVEGSAGGVQQSKNLGIPPQFVPDGIQDTGRLAATFGFDLDLWGRNRAALAAATSEAEAARVEAAQARLMLTTAIAAAYVDLAGQYAALDVAQDAVRVRDASAALSAERARAGIENRSAQRQGESRAAAARGDVVALEEAISLTRNRLAALVGAGPDRGLALERPTLAVPAAGLPADAGIALVGRRPDIVAARLRSEAAAKRIDVAKADFYPNISLSALVGLQSLGLSNLFDTGSEYGNGGVAFTLPIFDSGRLQGRYRGARADYDVAVASYDKTLIGALREVADVVRSREANVRQLTERRAALTAAAEASKLATLRYRAGLSNQIVALTAEDSAVALARAVADLEARQLALDISLIRALGGGYQISTGER
>NZ_CP019449.1|WP_077031796.1|3898246_3899395_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MADETAATPAEPSPDLGGNGAKRRKFLRILLIVVVVAALIWAAWYYLTQAGRVHTDNAYVGADSAVVTALVAGPVQEVRVAGTQAVKKGDILVILDDADAKLAVADAQAALRLARQRYGQAGANADAARARVVARGADVNQSRARLRDANAAVEKARAELARRESIAGTGAVSAEEITAARAALQSATAARDLASAGIASAQATQGSASGDLGAAEALVRGTTIYTAPDVAAAQARLEKAELDLARTVIRAPVDGIVTNKQVQVGQRIAAGAPIMTIVPIATAYVDANYKESQFQDIRIGQPVELLSDYYGDDVVFHGKVIGIAGGTGAAFSLIPAQNATGNWVKVVQRLPVRIQLDPKELKAHPLRVGLSMEATIDTRGKD
>NZ_CP019449.1|WP_077031797.1|3899404_3900949_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MASAAATTIPDEPAPLTGVRLFAAAFALALANFVVVLDTTIANVSVPHIAGGLAVSPTQGTWVITSYAVADAISVPLTGWLAMRFGTVRWFLYSIVGFGIFSFLCGISQTLDGLIVFRILQGLSGGPLMPLSQILLLRIFPREKAGIGLAIWAMTTTTAPILGPILGGLISDNWSWPWIFFINLPVVALCFFGVMSMLKPFETKKAKARIDTIGLILLVLSVGAFQLMLDTGREHDWFESTWIVGFAIIAAIAFAAFVIWELTDENPVVDLRVFRFRGFSFATIAISLGFGAFFAQVVLTPLWLQQVAGYTATETGYIVAWIGVFAVLLSPVAAGLIGKIDIRISISAGILWMAFISVLRASWNADVDYWTLALPHLLQGMGMPFFFVGLTALALSSVPPEKQTSAAGLMSFLRTLSGAMGTAIATSAWDSENRVARSELVGHMNGTAETMDLLQRAGLTLEQARAAIERLVDVQAATIGVLHLFLAAGVVFVIAAIAVWCAPLPKQVSMGAAH
>NZ_CP019449.1|WP_156878376.1|3901041_3901473_+|hypothetical-protein
MPIHHSWPLYDSARHFELGQLLGYDSLDAEPFASPRFRHIGHWSCDLADNSLNWSREVYEIFGLPEGASVSRGEAVALYAEPSRAAMEKLRAYAIRHRRGFTLDAEIRPATGAPRWMRLIAAPVCVGDAVVKLQGLKFLVPQR
>NZ_CP019449.1|WP_077031799.1|3901636_3902662_-|adenosine-deaminase
MPEAFLSREERAAFIAGLPKAELHLHIEGSLEPELMFELAQRNGVAIPFASVDEVRAAYAFSNLQDFLDIYYQGMGVLITEQDFYDLTAAYLARAHADNVRHVEIFFDPQGHTERGVAFETVIAGITRALDEAEAQHGITSKLIMCFLRHLSEADAEATLDEALPWLDRIDGVGLDSSEVGHPPSKFERVFARAKGLGLKIVAHAGEEGPPAYVHEALDLLKVDRIDHGNRSLEDPALVARLAAEGMTLTVCPLSNLKLCVVGDLAAHPLKTMLGAGLKATVNSDDPSYFGGYVGANYLAVADALDLSRDDLVTLAQNSFTGSFLDEVAKARHLAAIDAYA

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Crispr_ID: NZ_CP019449_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019449_3

3932358-3932443

Orphan

Consensus_repeat	Method
CGAGCGCGGCGCTGCGTTTCCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019449_3

>merge|NZ_CP019449|3|3932358-3932443|CRISPRCasFinder
CGAGCGCGGCGCTGCGTTTCCTCAGGCGGTCGGCGGCGTCGGTCGCGGCCTGCGCCTGGCGTTCGAGCGCGGCGCTGCGTTTCATC

>NZ_CP019449|3|2|3932358-3932443|CRISPRCasFinder
CGAGCGCGGCGCTGCGTTTCCTC	AGGCGGTCGGCGGCGTCGGTCGCGGCCTGCGCCTGGCGTT
CGAGCGCGGCGCTGCGTTTCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019449.1\|WP_077031820.1\|3922203_3923547_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NZ_CP019449.1\|WP_077031824.1\|3928715_3929234_-\|demethoxyubiquinone-hydroxylase-family-protein	unknown	unknown	gnl\|CDD\|377007
NZ_CP019449.1\|WP_077031822.1\|3924456_3926409_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP019449.1\|WP_156878297.1\|3926507_3927800_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277321
NZ_CP019449.1\|WP_077031832.1\|3934661_3935942_-\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NZ_CP019449.1\|WP_077031834.1\|3937199_3938831_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|378184
NZ_CP019449.1\|WP_058808781.1\|3940247_3941027_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|181800
NZ_CP019449.1\|WP_077031828.1\|3932588_3933017_-\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	unknown	unknown	gnl\|CDD\|349954
NZ_CP019449.1\|WP_077031825.1\|3929230_3929713_-\|disulfide-bond-formation-protein-B	unknown	unknown	gnl\|CDD\|376848
NZ_CP019449.1\|WP_077031829.1\|3933441_3934095_-\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NZ_CP019449.1\|WP_077032547.1\|3933049_3933442_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|272901
NZ_CP019449.1\|WP_077031826.1\|3929846_3931244_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NZ_CP019449.1\|WP_077031831.1\|3934366_3934630_-\|CopG-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|279710
NZ_CP019449.1\|WP_077031833.1\|3936019_3937141_+\|DUF3667-domain-containing-protein	unknown	unknown	gnl\|CDD\|378853
NZ_CP019449.1\|WP_077032546.1\|3928029_3928638_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019449.1\|WP_077031819.1\|3921408_3922200_-\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|238816
NZ_CP019449.1\|WP_077031830.1\|3934091_3934379_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226194
NZ_CP019449.1\|WP_077031818.1\|3920357_3920726_-\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|235358
NZ_CP019449.1\|WP_077031835.1\|3938942_3939866_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|236206
NZ_CP019449.1\|WP_077031821.1\|3923720_3924119_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019449.1\|WP_077031820.1\|3922203_3923547_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	1.13765e-102
NZ_CP019449.1\|WP_077031824.1\|3928715_3929234_-\|demethoxyubiquinone-hydroxylase-family-protein	gnl\|CDD\|377007	pfam03232, COQ7, Ubiquinone biosynthesis protein COQ7. Members of this family contain two repeats of about 90 amino acids, that contains two conserved motifs. One of these DXEXXH may be part of an enzyme active site.	7.67809e-84
NZ_CP019449.1\|WP_077032547.1\|3933049_3933442_-\|ribosome-silencing-factor	gnl\|CDD\|272901	TIGR00090, rsfS_iojap_ybeB, ribosome silencing factor RsfS/YbeB/iojap. This model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols. [Protein synthesis, Translation factors].	3.96589e-47
NZ_CP019449.1\|WP_156878297.1\|3926507_3927800_+\|hypothetical-protein	gnl\|CDD\|277321	cd00842, MPP_ASMase, acid sphingomyelinase and related proteins, metallophosphatase domain. Acid sphingomyelinase (ASMase) is a ubiquitously expressed phosphodiesterase which hydrolyzes sphingomyelin in acid pH conditions to form ceramide, a bioactive second messenger, as part of the sphingomyelin signaling pathway. ASMase is localized at the noncytosolic leaflet of biomembranes (for example the luminal leaflet of endosomes, lysosomes and phagosomes, and the extracellular leaflet of plasma membranes). ASMase-deficient humans develop Niemann-Pick disease. This disease is characterized by lysosomal storage of sphingomyelin in all tissues. Although ASMase-deficient mice are resistant to stress-induced apoptosis, they have greater susceptibility to bacterial infection. The latter correlates with defective phagolysosomal fusion and antibacterial killing activity in ASMase-deficient macrophages. ASMase belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: the phosphoprotein phosphatases (PPPs), Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.64804e-23
NZ_CP019449.1\|WP_077031822.1\|3924456_3926409_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.81989e-58
NZ_CP019449.1\|WP_077031832.1\|3934661_3935942_-\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NZ_CP019449.1\|WP_077031828.1\|3932588_3933017_-\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	gnl\|CDD\|349954	cd18081, RlmH-like, 23S-rRNA-pseudouridine1915-N3-methyltransferase RlmH. 23S rRNA (pseudouridine1915-N3)-methyltransferase RlmH catalyzes the addition of a methyl group at the N-3 position of pseudouridine Psi1915 in 23S rRNA to form m(3)Psi1915. This family of proteins belongs to the SPOUT methyltransferases. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	5.16657e-52
NZ_CP019449.1\|WP_077031825.1\|3929230_3929713_-\|disulfide-bond-formation-protein-B	gnl\|CDD\|376848	pfam02600, DsbB, Disulfide bond formation protein DsbB. This family consists of disulfide bond formation protein DsbB from bacteria. The DsbB protein oxidizes the periplasmic protein DsbA which in turn oxidizes cysteines in other periplasmic proteins in order to make disulfide bonds. DsbB acts as a redox potential transducer across the cytoplasmic membrane and is an integral membrane protein. DsbB posses six cysteines four of which are necessary for it proper function in vivo.	4.49474e-25
NZ_CP019449.1\|WP_077031829.1\|3933441_3934095_-\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	1.4051e-64
NZ_CP019449.1\|WP_077031834.1\|3937199_3938831_+\|alkaline-phosphatase	gnl\|CDD\|378184	pfam09423, PhoD, PhoD-like phosphatase.	2.99336e-114
NZ_CP019449.1\|WP_077031826.1\|3929846_3931244_-\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	1.90291e-127
NZ_CP019449.1\|WP_077031831.1\|3934366_3934630_-\|CopG-family-transcriptional-regulator	gnl\|CDD\|279710	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family. The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerization and not DNA binding as might have been expected.	0.000254206
NZ_CP019449.1\|WP_077031833.1\|3936019_3937141_+\|DUF3667-domain-containing-protein	gnl\|CDD\|378853	pfam12412, DUF3667, Protein of unknown function (DUF3667). This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. There is a single completely conserved residue P that may be functionally important.	7.69396e-13
NZ_CP019449.1\|WP_077031819.1\|3921408_3922200_-\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|238816	cd01638, CysQ, CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine biosynthesis (a principal route of sulfur assimilation).	8.62259e-59
NZ_CP019449.1\|WP_077031830.1\|3934091_3934379_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	1.62894e-08
NZ_CP019449.1\|WP_077031818.1\|3920357_3920726_-\|30S-ribosomal-protein-S13	gnl\|CDD\|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	6.21014e-76
NZ_CP019449.1\|WP_077031835.1\|3938942_3939866_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|236206	PRK08260, PRK08260, enoyl-CoA hydratase; Provisional.	1.85598e-172
NZ_CP019449.1\|WP_058808781.1\|3940247_3941027_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|181800	PRK09362, PRK09362, phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed.	9.4112e-156

>NZ_CP019449.1|WP_077031826.1|3929846_3931244_-|S41-family-peptidase
MTETTKKPVSTKRRFALWQGAAALSTLALVPLATGAMATVDTATTDEISRFMDVFLEVRSNYVEPVDDSKLIEGAINGMLASLDPHSGYLDARGFSNLRTQTDGEYGGLGLSVTMEDGVVKVIAPMSDTPGDRAGIKAGDYITHINKELIFGLTLDEAVEQMKGRPGTKVDITVVREGQSKPMELSLTREIIDLKPVKWEAKGDVGVLTVSSFSADATTDLRAAMLAVEKSMGKKPRGWVLDLRSNPGGLLDEAVGISDLFLERGEIVSQRGRRKGDIERYFAEPGDLAGGAPVIVLIDAGSASASEIVAGALQDQHRAVVMGERSFGKGSVQTVLPLTDTTALRLTTARYYTPSGRSVQEGGIEPDIRVPQLSDPDYKDRPRFRESDLRRHLVNEKKVDNSLLEKDEKDDPRFTATAEELKAKGIDDFQLNYALQTIGRINPAARMAQSTKPPAKPASKPVRRN
>NZ_CP019449.1|WP_077031825.1|3929230_3929713_-|disulfide-bond-formation-protein-B
MLNSRIAAPLVALAAPLLLYGGALVSQLGFGLHPCEMCYWQRWPHQAAIVLALLALLLNKNDRAMRAFTLLAAIAIAVSGAIGVFHAGVEYGFWEGLTTCSTTGGGPVTLESIMAAPIVRCDVAQWTLGGISLAGYNAIFSFGGALLVLILLRRRSTASA
>NZ_CP019449.1|WP_077031824.1|3928715_3929234_-|demethoxyubiquinone-hydroxylase-family-protein
MSSSDKNASMIRVDQAGEYGATRIYAGQLAVMGDRHPMAREIAHMAEQEERHRKFFDAMVAKRGVRPTALQPVWNVAGFALGAVTAALGPRAAMACTAAVETEIDRHYQHQLEELGDSDPELSAAVADFRAEELEHKDAALAAGAESAPGYPLLSFAIRAGCRAAIALSKRI
>NZ_CP019449.1|WP_077032546.1|3928029_3928638_-|hypothetical-protein
MTRLPLAALFLATSLFALPAAAQEADTSAAEKINQVIVYGNDQCAPSAADEIVVCNRLPEQDRYRVPQLFRGGDPLDPRNQAWLNRVTSMERVGRFGTDSCSPVGLGGFTGCTQALVAGARAEEQAADKTDWQAMIADERAKRIAGIDAASDEVEAAVVAEERAMAERQKAAEELEAQASGNAPMREQADPEASELPVPPQR
>NZ_CP019449.1|WP_156878297.1|3926507_3927800_+|hypothetical-protein
MGLAAMLGLAGCAAGPAPSGGARPLIAAQGGQPGSFLTLSDVHYDGNSADIWGQNQETSAILWTRAQAEAKGIVAADDPGFILYLGDLPAHGQSEAARETQFKAVLDGLQGLVAGTSKRLLFLPGNNDSDGEDYCAFTTGGATPFDAASDPSAWPVINAQPGDIIDAGQLARGFYSAYPLGKSAPLRLLALNTVIFNPNYGTFQGASCVDATTRQADANAQIEWLYAQLTDAALKKEKVIVAMHVPPGIDGYGGAPNWDPGRAYTGSAPGLTRYTGRPVQGVYLALVAAFSKQIVGTLSSHTHLNDLRRLRDCDGNVTELDLSIPAVTTDHGSNPAMKLLRHDARYEWLAAETRYASETTGKDWVPANRFSFADNYPCSNCDGSETLAERIAKVAEQDLLGDMLAYLMVKRSVPSNPRHYKASMDVTCGG
>NZ_CP019449.1|WP_077031822.1|3924456_3926409_+|S9-family-peptidase
MRHLALLAALALPLAPALAQAPATPATPAAPVAPRPAALVADGMPDVPAELAAATRPYMENRGASFVGWNPVDKSMLIATRFGNTSQIHRVAVPMGARKQMTFEEEPVGGAAWSPKTGDLMLLQKDIGGNEFYQIYAMKDGRLDLLTDGKSRNGLNAWSKDGQLVAYTSTRRNGRDSDIYLIDPRNPKSDRLVAEVEGGGWGLLDFAPDKSWALVGKYSSVQKSDFFRLDLKTGAMTPIGDHTKTVSRGGGQFAPDGTIWITSDEGAEFERLGTLDPATGAFTPRGAAEKWEVSGFDVADDGSFIAYTVNEAGMSKLRLLDPKTGAVRTVEALPPGIIGGVEIAPWGEIGISFTSARAAADAYSVDPKTLKVTRWTESETGGLDVTKNVEPELVKVKSFDGLEVSGFLYRPDPAKFPGKRPMIMNVHGGPEGQSRPGFMGRTNYLLNEMGIAVFYPNVRGSTGYGKTFVSLDNGPFKREDSVKDMGAFLDHFAKDKTLDPARFALTGGSYGGYMCYAAAIHYSDKLRANLCVVAISNFVTFLENTQDYRRDLRRVEYGDERVPEQRAKLLEISPLTRVAEIKKPLFIVTGANDPRVPASEADQIVKAVRANGGTAWHLVGTNEGHGFAKKENADYNFWASLVFWKQYLLN
>NZ_CP019449.1|WP_077031821.1|3923720_3924119_-|hypothetical-protein
MASTFGPRLFRRSTRSVPTARHLGRRMTFHAAAALLVFAVLQIWLVSSAIAAGAPTALTFVALALLLILAVPIARTTERRWYHLSRQALASWGLHARFRRDVRRLWVAALALPFVWVSGAMAATTGLAVIGG
>NZ_CP019449.1|WP_077031820.1|3922203_3923547_-|TldD/PmbA-family-protein
MLTVAEALDRAQMLCDAATKAGADAADALYYCNAATSVSMRLGALEDVESSEGQDIALRVFVGQRSASVSTADMDAGELAKLVERCVAMAREAPEDIYAGLAPQDLLYKGPIPDLDLDDASEADPQALRAAALAVEEAARAVAGVTNSEGGTASHSRTRIALATSHGFAGGYGASGHSLSASVIAGEGASMQRDYGWHSAHYLADLEGITEIGTRAGTRAVARLNPGKAPTGKLPILFDPRVSSSLVSHLLGAISGPAIARGTSFLLGKEEQILFDSAIFIRDEPHRPRGLRSRAFDGEGLPTAARDLVAGGKLTGWLLDTASAKQLGLTPTGHASRGGGASGVAVSNVHLAAGSVTPAALMADVAEGIYVTELIGQGVNPVTGDYSRGASGFAIRGGRLAEPIAEFTIAGNLIDMFAALIPADDLAFRHATNVPTLRIDGMTVASS
>NZ_CP019449.1|WP_077031819.1|3921408_3922200_-|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MPGRNLEAVIAATREVGDMAMARWRGEGKAVAVWNKSHDNPVSDVDLAVDARLKAVLGAMVPEAGWLSEETADNEDRLACRAMWCVDPIDGTRDFIRGRPGWCVSVALVIDGTPELGVLYAPALDELWVAQKGRGATLNGESLRASRRMIFDGSRVPADSLPKIDRDLIMVTKPNSIALRMALVADDRADLVATLRWGFEWDVAAAALIAAEAGAAVSDAFGEPLRFNTPRAQAFGVIACAPGIHRAVVARLHDRAVALTAAP
>NZ_CP019449.1|WP_077031818.1|3920357_3920726_-|30S-ribosomal-protein-S13
MARIAGVNLPTNKRVIIALTYIHGIGRKTAVDIADKLGIDHTRRVQDLSDAEILQIRETLDADHTVEGDLRRTTAMNIKRLMDLACYRGLRHRKGLPVRGQRTHTNARTRKGKAKPIAGKKK
>NZ_CP019449.1|WP_077031828.1|3932588_3933017_-|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH
MLLHIIARGRIGRSPEADLVGRYMKRVTWPQKITELPDTGGKVPAAAPGSRTILLDETGEQITSLDLAKLLERWRDDGVREARFCLGAADGFTPDERKNADKAIAFGRATWPHLMARAMLAEQLWRATSIIAGHPYHREGQQ
>NZ_CP019449.1|WP_077032547.1|3933049_3933442_-|ribosome-silencing-factor
MAASKDAAPGAAPNDSVDALHALILHQLDEDQAQETISIPLAGKSSIADHMVIASGRSTRHVSAIADKLAQRIKQEAGRLVRVEGLPNADWVLIDAGDVIVHLFRPEVRSFYNLERMWSFGDAPPVTAVN
>NZ_CP019449.1|WP_077031829.1|3933441_3934095_-|nicotinate-nucleotide-adenylyltransferase
MITTGLLGGSFNPAHGGHRAISLNAIDALGPDELWWLVSPGNPLKPAKGMAPLPARLGSAQRVARRSPIRATAIEAELGTRYTVHTLKKLVRKYPNRRFVWIMGADNLAQLPRWRDWRGIARLMPIAVVARPGYNGRTHAAEAMGWLRRFVRPGDQKLHWTDWRPPALVFLRFSPDVRSATAIRQANPRWFESHAGRAMRDPLTHSRLAAHERNEKA
>NZ_CP019449.1|WP_077031830.1|3934091_3934379_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MLGIIWSEKAIADLVALNDWLTKYRRPLEAAESIRAIRDQVSRLDRFPAVGSPVHAGTRKLLIKGQPFVLLYELVDHRLIILRLVHNRSDWQSLL
>NZ_CP019449.1|WP_077031831.1|3934366_3934630_-|CopG-family-transcriptional-regulator
MTKHAVISARIDAETLELVDKIVAEQGRSRAWFVAQAVRHAAEQEARFAAFVQEGRDDVAAGRVTDHAEVVKMMNDMIARHEARCSE
>NZ_CP019449.1|WP_077031832.1|3934661_3935942_-|glutamate-5-semialdehyde-dehydrogenase
MTAKAHQSAVPDADALIADMGARARAAAKKLAVVPTADKAAGLRAAAAQLRLRADSILDANRRDMAAGKSAGLSAAMLDRLRLDDARLGGIADAVEAVAALPDPVGMEIDRAVRPNGMVLSRVRVPLGVVGIIYESRPNVTADAAALGLMSGNAVILRGGSEAVQSNRAIHAALAAGLASVGLAADAVQLVPTQDRAAVGALLRAQGLVDIIIPRGGKSLVARVQDEARVPVLAHLDGINHLYIDGAADPAKAAALAVNAKMRRTGVCGATETILIDRAYPAPLAIVDALIKAGCEVRGDKEVAALSPHVTPASANDWDCEYLDAIVSVAMVGGLKGALAHIDAHSSRHTDAIVTEDERVAERFLTEVDSAIVMHNASTQFADGGEFGLGAEIGIATGRLHARGPVALEGLTTYKWLVRGSGQTRP
>NZ_CP019449.1|WP_077031833.1|3936019_3937141_+|DUF3667-domain-containing-protein
MTGDIEGIGAAVTAGLAARAVEPGHGQAAAHEGLRCLNCGTSLQGSHCHHCGQRADVHRSFGAIGHDLVHAIFHFEGKIWNTLPLLTWRPGDLTRRYIHGERARFVSPLALFLFAVFLTYAVLAMVGSGGGLGEGIAKAADAQTRSNALEASFDEEVARVDARLAAKDVTAEEKKKLIEERETLEKGAAYLGVEPAMTDAERAKGPPVLEDPKQQVMSSADFLSRLKVDTGVPAIDKGLTKAFANPALIFYKLQANAYKFAWALIPLSLPFMWLLYPFSRRFHTYDHFVFVTYSISFMLLLFVVVRLLNLTVVGDVATFLAMLYVPFHMYRQLRGAYRSSRFGSLVRASLLLFFSLWAVITFMLLLLALGTMG
>NZ_CP019449.1|WP_077031834.1|3937199_3938831_+|alkaline-phosphatase
MHELWGQIDRRLLIKLGTAGLGALALPGAAHAMMAQGFTHGVASGEPGANSVLLWTRYAAASDARLTAEVAETPDFTKIVAGGAVTASGERDHTAKLTVDGLLPGRWYFYRFVAPDGSKSVTGRTRTLPQGPTGAFTLALFSCSNLPFGWFNAYAHANARGDIDLVAHVGDYLYEYPVGNYPSRGQLLPGREIQPAHEIVALADYRLRYAAYRADPDLQRLHQLFPMIAQWDDHEFTNDAWKGGAENHNEGEGNWTDRMAAAERAYREWMPVAETRWRDYQVGDLATIFLPETRITGRDRPFEFDEIVAGGGDATAKLKTFAETAYRDPARQMMGADQEKWLFDGFAASTKAGTRWQVCAQQVVMGSVFTPPESANWFGTDLSENIRRRVATAQAAAKAGLPLNMDAWDGYPAARGRLLAAAQKADADLVTLTGDTHNAWAYDLSEDGRPAGIEIAGQSVTSPGYESYTRGISDKTRVRAIRGASPQLKWANTQDRGYVTVALTPDKVIASWHMLETIREHRPTMKASHSMTAMRGKRMFEAV
>NZ_CP019449.1|WP_077031835.1|3938942_3939866_-|crotonase/enoyl-CoA-hydratase-family-protein
MSFEEIRLDRHEGIALLTLYRPGKMNAFTTQMMTEIVAALDECDADDGVRAVVFTGDGERAYCAGADLSAGGSTFDYDKRTDKAALLPDGTSPSPVAEDGTIDWSHPLIRDGGGRVSMRIFESKKPVLGAINGAAVGIGATMTLSMDARLASDTARYGFVFARRGIVPEAASSWFLPRLVGIQTALDWCYSGRLIPAAEAHEKGLVQSVHAPGELVDAAIAKARELTGDSAPVSVALTRHMMWRMLGAPHPMSAHRWDSRVIFARGRSPDAMEGVTSFLEKRPPNFTASVANDYPVFGEWEDAPPYG
>NZ_CP019449.1|WP_058808781.1|3940247_3941027_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MARRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKGTISGKGVLNNRISEHVFTLLGNIGVPTHFIRRLNMREQLIRQVEIVPIEVIVRNVAAGTLSKRLGIEEGTQLPRTLIEYCYKDDALGDPLVAEEHIACFNWCSQDELHDIQDMAIRINDFMSGMFAAVGIRLIDFKLEFGRLYEGDFSRIILADEISPDGCRLWDMTTNEKLDKDRFRRDLGGEVEAYQEVARRLGLLPEGGDHAVLDLESHRKKKGS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019449_3	3.1\|3932381\|40\|NZ_CP019449\|CRISPRCasFinder	3932381-3932420	40	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	451791-451830	7	0.825

1. spacer 3.1|3932381|40|NZ_CP019449|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.825

aggcggtcggcggcgtcggtcgcggcctgcgcct-ggcgtt	CRISPR spacer
gcgccctcggcggcggcggtcgcggccagcgcctcggcgt-	Protospacer
. **  ********* *********** ****** *****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1098158 : 1105364

Pseudomonas_phage(33.33%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077029617.1\|1098158_1099739_-\|tRNA	methionine--tRNA ligase	A0A1V0SHR2	Klosneuvirus	5.4e-99	37.0
WP_077029618.1\|1099777_1100755_-	DNA polymerase III subunit delta'	S5WKH4	Pseudomonas_phage	1.7e-10	34.2
WP_077029619.1\|1100745_1101369_-	dTMP kinase	Q2Z0N0	Pseudomonas_phage	4.7e-22	37.2
WP_077029620.1\|1101365_1102298_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	4.4e-32	37.7
WP_077029621.1\|1102303_1103299_-	septal ring lytic transglycosylase RlpA family protein	F5B3X9	Synechococcus_phage	4.4e-14	52.6
WP_077032225.1\|1103282_1104347_-	lytic murein transglycosylase	NA	NA	NA	NA
WP_077029622.1\|1104500_1105364_+	FkbM family methyltransferase	A0A222Z098	Streptomyces_phage	8.5e-06	26.9

DBSCAN-SWA_2

1116566 : 1124583

Synechococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077029631.1\|1116566_1117679_-	CDP-glucose 4,6-dehydratase	A0A222YY99	Synechococcus_phage	4.4e-15	35.4
WP_077029632.1\|1117687_1118473_-	glucose-1-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_077029633.1\|1118593_1120057_-	YdiU family protein	A0A075BSJ0	Microcystis_phage	2.4e-37	32.2
WP_077029634.1\|1120100_1121042_-	GDP-L-fucose synthase	D1LW79	Prochlorococcus_phage	4.5e-93	54.4
WP_077029635.1\|1121034_1122087_-	GDP-mannose 4,6-dehydratase	M1IBC3	Acanthocystis_turfacea_Chlorella_virus	1.2e-126	63.4
WP_077032226.1\|1122285_1123281_+	SDR family NAD(P)-dependent oxidoreductase	A0A0F7L843	uncultured_marine_virus	9.1e-12	25.4
WP_077029636.1\|1123314_1124583_+	nucleotide sugar dehydrogenase	M1I178	Paramecium_bursaria_Chlorella_virus	6.8e-28	30.7

DBSCAN-SWA_3

1159826 : 1194603

Erwinia_phage(12.5%)

tRNA,portal,terminase,protease,integrase

attL 1166061:1166077|attR 1180461:1180477

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077029666.1\|1159826_1160393_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_077029667.1\|1160398_1161700_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	2.8e-37	29.7
WP_077029668.1\|1161842_1162688_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_156878152.1\|1162797_1163775_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_083720644.1\|1163728_1164727_+\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_077029669.1\|1164821_1166765_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	A0A0P0CCN8	Ostreococcus_mediterraneus_virus	1.3e-115	43.5
1166061:1166077	attL	NA	NA	NA	NA
WP_077029670.1\|1166788_1167280_+	hypothetical protein	NA	NA	NA	NA
WP_077029671.1\|1167290_1167896_+	hypothetical protein	NA	NA	NA	NA
WP_058808280.1\|1167965_1168310_-	DNA-directed RNA polymerase subunit omega	NA	NA	NA	NA
WP_077032232.1\|1168461_1169658_+	cardiolipin synthase B	NA	NA	NA	NA
WP_156878153.1\|1169661_1170300_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_077029672.1\|1170489_1171800_+	MFS transporter	NA	NA	NA	NA
WP_156878154.1\|1171836_1174158_-	CDC48 family AAA ATPase	G9E6G3	Micromonas_pusilla_virus	1.7e-48	43.5
WP_077029674.1\|1174296_1175175_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_058808285.1\|1175491_1175806_-	DUF1905 domain-containing protein	NA	NA	NA	NA
WP_077029675.1\|1175910_1176927_-	peptidylprolyl isomerase	NA	NA	NA	NA
WP_083720646.1\|1177240_1178701_+\|integrase	integrase arm-type DNA-binding domain-containing protein	A0A2L0V119	Agrobacterium_phage	2.3e-96	42.5
WP_156878155.1\|1178697_1179177_-	hypothetical protein	NA	NA	NA	NA
WP_083720648.1\|1179214_1179463_-	AlpA family phage regulatory protein	NA	NA	NA	NA
WP_077029678.1\|1179536_1179812_-	hypothetical protein	NA	NA	NA	NA
WP_156878156.1\|1179808_1180021_-	hypothetical protein	NA	NA	NA	NA
WP_077029681.1\|1180222_1180477_-	hypothetical protein	NA	NA	NA	NA
1180461:1180477	attR	NA	NA	NA	NA
WP_077029682.1\|1180473_1180797_-	hypothetical protein	NA	NA	NA	NA
WP_077029683.1\|1180912_1181137_-	hypothetical protein	NA	NA	NA	NA
WP_077029684.1\|1181133_1181610_-	hypothetical protein	NA	NA	NA	NA
WP_083721131.1\|1181609_1182851_-	ATP-binding protein	NA	NA	NA	NA
WP_083720650.1\|1182850_1184002_-	hypothetical protein	A0A0U2C144	Paracoccus_phage	1.7e-14	33.5
WP_077029687.1\|1184194_1184950_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_156878157.1\|1185036_1185489_-	hypothetical protein	NA	NA	NA	NA
WP_077029689.1\|1185599_1185812_+	hypothetical protein	NA	NA	NA	NA
WP_077029690.1\|1185817_1186816_+	hypothetical protein	A0A0K1LMQ9	Caulobacter_phage	2.7e-19	35.2
WP_083720652.1\|1186812_1188342_+	DUF3987 domain-containing protein	NA	NA	NA	NA
WP_156878158.1\|1188334_1188916_+	hypothetical protein	NA	NA	NA	NA
WP_156878159.1\|1189271_1189757_+	hypothetical protein	NA	NA	NA	NA
WP_156878160.1\|1189969_1190140_+	hypothetical protein	NA	NA	NA	NA
WP_077029693.1\|1190132_1190438_+	HNH endonuclease	NA	NA	NA	NA
WP_156878161.1\|1190437_1190614_+	hypothetical protein	NA	NA	NA	NA
WP_077029695.1\|1190610_1190898_+	hypothetical protein	NA	NA	NA	NA
WP_077029696.1\|1191050_1191497_+\|terminase	P27 family phage terminase small subunit	NA	NA	NA	NA
WP_077029697.1\|1191489_1193301_+\|terminase	terminase	B0VK29	Azospirillum_phage	5.9e-126	42.2
WP_083720654.1\|1193313_1194603_+\|portal	phage portal protein	Q3HQS8	Burkholderia_phage	1.4e-73	42.9

DBSCAN-SWA_4

1242281 : 1247626

Cafeteria_roenbergensis_virus(66.67%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083720672.1\|1242281_1242887_-\|tail	phage tail protein	E3T4R8	Cafeteria_roenbergensis_virus	5.4e-15	32.0
WP_077032243.1\|1242952_1243534_-\|tail	phage tail protein	E3T4R8	Cafeteria_roenbergensis_virus	1.4e-15	34.5
WP_083721132.1\|1243603_1244191_-	hypothetical protein	E3T4R8	Cafeteria_roenbergensis_virus	9.2e-12	31.4
WP_077029738.1\|1244360_1244987_-	hypothetical protein	A0A2R4A082	Microbacterium_phage	5.4e-10	39.0
WP_083720674.1\|1245031_1245643_-	hypothetical protein	E3T4R8	Cafeteria_roenbergensis_virus	1.1e-10	37.1
WP_083720676.1\|1245689_1246301_-	hypothetical protein	NA	NA	NA	NA
WP_077029740.1\|1246403_1246994_-	hypothetical protein	NA	NA	NA	NA
WP_077032246.1\|1247074_1247626_-	hypothetical protein	A0A0U4JYA4	Arthrobacter_phage	1.0e-12	35.0

DBSCAN-SWA_5

2067153 : 2075097

Acinetobacter_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077030404.1\|2067153_2068272_-\|protease	cysteine protease StiP family protein	A0A172Q0S8	Acinetobacter_phage	1.3e-30	33.1
WP_077030405.1\|2068276_2069038_-	sucrose-6-phosphate hydrolase	NA	NA	NA	NA
WP_077030406.1\|2069021_2070170_-	hypothetical protein	A0A172Q0Y1	Acinetobacter_phage	2.4e-16	31.6
WP_077030407.1\|2070247_2070502_-	hypothetical protein	NA	NA	NA	NA
WP_077030408.1\|2070511_2071639_-	trypsin-like peptidase domain-containing protein	A0A1B1IRD3	uncultured_Mediterranean_phage	1.6e-12	33.5
WP_077032314.1\|2071658_2072669_-	ATP-dependent carboxylate-amine ligase	NA	NA	NA	NA
WP_077030409.1\|2072720_2073302_-	TerD family protein	A0A2P1N0L4	Streptomyces_phage	9.7e-06	30.2
WP_077030410.1\|2073375_2073951_-	TerD family protein	K4JRX3	Caulobacter_phage	2.4e-28	41.8
WP_077030411.1\|2074026_2075097_-	DUF475 domain-containing protein	A0A172Q0Y5	Acinetobacter_phage	2.6e-65	43.5

DBSCAN-SWA_6

2385982 : 2428263

Bacillus_phage(18.75%)

head,capsid,portal,tail,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077030652.1\|2385982_2386903_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_058809069.1\|2386959_2387493_+	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_077032349.1\|2387678_2388224_+	YfiR family protein	NA	NA	NA	NA
WP_077030653.1\|2388220_2389426_+	diguanylate cyclase	NA	NA	NA	NA
WP_077030654.1\|2389440_2389929_+	OmpA family protein	NA	NA	NA	NA
WP_077030655.1\|2389971_2390835_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	2.4e-69	48.4
WP_077032350.1\|2390871_2391603_-	aquaporin Z	NA	NA	NA	NA
WP_083720830.1\|2391700_2392987_-	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	2.1e-08	44.2
WP_077030656.1\|2393167_2393473_+	hypothetical protein	NA	NA	NA	NA
WP_077030657.1\|2393616_2394285_-	helix-turn-helix transcriptional regulator	A5X9F5	Aeromonas_virus	2.7e-20	44.9
WP_077030658.1\|2394411_2394666_+	hypothetical protein	NA	NA	NA	NA
WP_077032352.1\|2394740_2394986_+	hypothetical protein	NA	NA	NA	NA
WP_077030659.1\|2394982_2395828_-	hypothetical protein	NA	NA	NA	NA
WP_077030660.1\|2395847_2397071_-	glycosyltransferase, exosortase A system-associated	NA	NA	NA	NA
WP_077030661.1\|2397288_2398677_+	putative O-glycosylation ligase, exosortase A system-associated	NA	NA	NA	NA
WP_077030662.1\|2398751_2399762_+	DNA topoisomerase IB	A0A0U2TSJ7	Niemeyer_virus	3.8e-29	29.6
WP_077030663.1\|2399795_2400977_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_077030664.1\|2401073_2401532_+	MaoC family dehydratase	NA	NA	NA	NA
WP_077030665.1\|2401588_2402770_+	acetyl-CoA C-acyltransferase	NA	NA	NA	NA
WP_077030666.1\|2402771_2403356_+	carboxymuconolactone decarboxylase	NA	NA	NA	NA
WP_077030667.1\|2403372_2403663_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_083720832.1\|2403617_2404124_+	DUF3617 family protein	NA	NA	NA	NA
WP_077030669.1\|2404130_2404598_-	redox-sensitive transcriptional activator SoxR	NA	NA	NA	NA
WP_077030670.1\|2404685_2405081_+	glyoxalase	NA	NA	NA	NA
WP_077030671.1\|2405146_2405611_+	general stress protein	NA	NA	NA	NA
WP_077030672.1\|2405815_2407036_-	polyhydroxyalkanoate depolymerase	NA	NA	NA	NA
WP_077030673.1\|2407312_2407570_+	hypothetical protein	NA	NA	NA	NA
WP_077030674.1\|2407662_2409465_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.8e-53	29.9
WP_077030675.1\|2409499_2410036_+	DUF1993 domain-containing protein	NA	NA	NA	NA
WP_077030676.1\|2410248_2410683_-	biopolymer transporter ExbD	NA	NA	NA	NA
WP_077030677.1\|2410935_2412057_-	OmpA family protein	NA	NA	NA	NA
WP_077030678.1\|2412193_2412640_-	DUF2793 domain-containing protein	F4YXU6	Roseobacter_phage	4.7e-08	34.9
WP_077030679.1\|2412652_2414830_-	hypothetical protein	M4QNR6	Tetraselmis_viridis_virus	7.5e-51	31.7
WP_156878210.1\|2414832_2415282_-	peptidoglycan endopeptidase	NA	NA	NA	NA
WP_077032354.1\|2415250_2416078_-	DUF2163 domain-containing protein	K4JUH7	Caulobacter_phage	2.4e-05	39.2
WP_077030680.1\|2416077_2418399_-	DUF2460 domain-containing protein	A0A0P1KKK5	Acinetobacter_phage	3.0e-50	34.5
WP_077030681.1\|2418398_2418965_-\|tail	tail tape measure protein	D6PGG3	uncultured_phage	4.7e-05	30.2
WP_077030682.1\|2418954_2419161_-\|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_077030683.1\|2419157_2419454_-	gene transfer agent family protein	NA	NA	NA	NA
WP_077030684.1\|2419468_2419876_-\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_077030685.1\|2419926_2420262_+	hypothetical protein	NA	NA	NA	NA
WP_156878211.1\|2420438_2420858_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_077030686.1\|2420830_2421379_-	hypothetical protein	NA	NA	NA	NA
WP_077030687.1\|2421378_2421657_-	hypothetical protein	NA	NA	NA	NA
WP_156878212.1\|2421820_2421988_-	hypothetical protein	NA	NA	NA	NA
WP_077030688.1\|2421984_2422530_-	hypothetical protein	A0A1Q1PUS1	Escherichia_phage	4.8e-15	40.1
WP_077030689.1\|2422542_2423352_-	hypothetical protein	NA	NA	NA	NA
WP_077030690.1\|2423480_2424623_-\|capsid	phage major capsid protein	A0A192Y5T6	Salmonella_phage	2.5e-82	47.7
WP_077032356.1\|2424628_2425036_-\|head,protease	HK97 family phage prohead protease	A0A2H4JAI0	uncultured_Caudovirales_phage	1.9e-11	36.3
WP_077030691.1\|2425221_2425533_-	hypothetical protein	K4I011	Acidithiobacillus_phage	1.6e-10	44.4
WP_077030692.1\|2425630_2426737_-\|portal	phage portal protein	A0A0K1LLE7	Bacillus_phage	5.0e-43	34.0
WP_156878354.1\|2427009_2428263_-	ATP-binding protein	A0A1B1IQC4	uncultured_Mediterranean_phage	4.0e-57	36.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019449

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection