CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019457	Streptomyces lydicus strain GS93 isolate 23 chromosome, complete genome	10 crisprs	WYL,csa3,casR,DEDDh,cas4,cas3,DinG	3	2	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019457_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_1

182287-182376

Orphan

Consensus_repeat	Method
GTCGTCCCCGCACCCGCGGGGGTAGTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_1

>merge|NZ_CP019457|1|182287-182376|CRISPRCasFinder
GTCGTCCCCGCACCCGCGGGGGTAGTTCCAACATCCCGCCCGTCGAGATCACCGACGACACGTCGTCCCCGCACTCGCGGGGGTAGTTCC

>NZ_CP019457|1|1|182287-182376|CRISPRCasFinder
GTCGTCCCCGCACCCGCGGGGGTAGTTCC	AACATCCCGCCCGTCGAGATCACCGACGACAC
GTCGTCCCCGCACTCGCGGGGGTAGTTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_033271021.1\|174224_174461_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_107431023.1\|185383_186517_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP019457.1\|WP_077194541.1\|178055_178736_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|372627
NZ_CP019457.1\|WP_159031792.1\|190280_190862_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214864
NZ_CP019457.1\|WP_077191266.1\|176250_176622_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NZ_CP019457.1\|WP_077194542.1\|180205_180823_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP019457.1\|WP_099872434.1\|176855_177041_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077191272.1\|187176_187821_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP019457.1\|WP_077191271.1\|186687_186786_-\|3-oxoadipate-enol-lactone-hydrolase	unknown	unknown	unknown
NZ_CP019457.1\|WP_077191270.1\|183985_184984_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|132489
NZ_CP019457.1\|WP_077191273.1\|187973_189425_+\|amidase	unknown	unknown	gnl\|CDD\|223232
NZ_CP019457.1\|WP_033270947.1\|178840_179092_+\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NZ_CP019457.1\|WP_159031793.1\|193724_194282_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077191268.1\|181293_182187_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|377856
NZ_CP019457.1\|WP_078617443.1\|179117_179972_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197317
NZ_CP019457.1\|WP_143686383.1\|173744_174044_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077191277.1\|195113_195839_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238194
NZ_CP019457.1\|WP_079271242.1\|174737_175997_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP019457.1\|WP_143686385.1\|183477_183867_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197292
NZ_CP019457.1\|WP_077191274.1\|189594_190086_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_077191272.1\|187176_187821_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.7866e-14
NZ_CP019457.1\|WP_077194541.1\|178055_178736_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	1.08913e-53
NZ_CP019457.1\|WP_159031792.1\|190280_190862_+\|hypothetical-protein	gnl\|CDD\|214864	smart00860, SMI1_KNR4, SMI1 / KNR4 family. Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.	7.4807e-11
NZ_CP019457.1\|WP_077191266.1\|176250_176622_+\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	2.70879e-24
NZ_CP019457.1\|WP_077194542.1\|180205_180823_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	2.41531e-40
NZ_CP019457.1\|WP_107431023.1\|185383_186517_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	2.22606e-98
NZ_CP019457.1\|WP_077191273.1\|187973_189425_+\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	4.54359e-113
NZ_CP019457.1\|WP_077191270.1\|183985_184984_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|132489	TIGR03448, mycothiol_MshD, mycothiol synthase. Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.1105e-11
NZ_CP019457.1\|WP_033270947.1\|178840_179092_+\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	4.0611e-26
NZ_CP019457.1\|WP_077191268.1\|181293_182187_+\|recombinase-family-protein	gnl\|CDD\|377856	pfam07508, Recombinase, Recombinase. This domain is usually found associated with pfam00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.	2.64365e-22
NZ_CP019457.1\|WP_078617443.1\|179117_179972_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	1.27175e-99
NZ_CP019457.1\|WP_077191277.1\|195113_195839_-\|peptidylprolyl-isomerase	gnl\|CDD\|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	2.00954e-41
NZ_CP019457.1\|WP_079271242.1\|174737_175997_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	8.51919e-54
NZ_CP019457.1\|WP_143686385.1\|183477_183867_+\|hypothetical-protein	gnl\|CDD\|197292	cd09196, PLDc_yTdp1_2, Catalytic domain, repeat 2, of yeast tyrosyl-DNA phosphodiesterase. Catalytic domain, repeat 2, of yeast tyrosyl-DNA phosphodiesterase (yTdp1, EC 3.1.4.-). yTdp1 is involved in the repair of topoisomerase I DNA lesions by hydrolyzing the topoisomerase from the 3'-end of the DNA during double-strand break repair. Unlike human Tdp1 whose substrate-binding pocket can accommodate a fairly large topoisomerase I peptide fragment, yTdp1 has a preference for substrates containing one to four amino acid residues. The monomeric yTdp1 contains two copies of a variant HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue), which consists of the highly conserved histidine and lysine residues, but lacks the aspartate residue that is well conserved in other phospholipase D (PLD, EC 3.1.4.4) enzymes. Like other PLD enzymes, yTdp1 may utilize a common two-step general acid/base catalytic mechanism, involving a DNA-enzyme intermediate to cleave phosphodiester bonds. A single active site involved in phosphatidyl group transfer would be formed by the two variant HKD motifs from the N- and C-terminal domains in a pseudodimeric way.	0.00194472

>NZ_CP019457.1|WP_077191268.1|181293_182187_+|recombinase-family-protein
MIFYDLDRLVRQPRDLEDLIDIVEYVKRPVTGATGGRMNLINDSDRHMARMMCVMALKSSEDTARRVARQHLSAAQNGLAQGRIAYGWVRKGERKGQLVPHEADVVVRIFQDFMSGESAYSIARAFNAEGIKPPAARTWSSTMIAKMLRNPRYAGMVSYAGNHRVQAAMAGDGWSLVLFDDEGRPLLGTWEPIVTPKLWSQVQFEWQRRRQKAGIKPGESGSAPVNKYLLSGILRCHKCHRGLVGHSYKQRRSGKIIRNYMCPPSDRGGCGSPRASSGQSTGCAPSAHPPPYSGSVP
>NZ_CP019457.1|WP_077194542.1|180205_180823_-|flavin-reductase-family-protein
MRTDFDPAVMSRNDFYRLLTATVVPRPIAWVSTTSADGTHNLAPHSFFTIASVAPPVVQFSSVGRKDTLRNIEATGQFVVNFASESLFEQINDTGTDFPHGVSEFEAVGIESEPSLRVKPLRVAASPVALECEVHTTIGIGDSTIVFGRVVHAVVSDDVLADGHPEVTKLKPLSRLGKDEWATLGEVRELPRIRHADWRGPASDR
>NZ_CP019457.1|WP_078617443.1|179117_179972_-|endonuclease/exonuclease/phosphatase-family-protein
MAAAAVAGPVVSAAYGSGTAYAADDGPALRVMTFNLRYASDVRPHSWAERRPVMRSLLRRAAPQLLGTQEGLYGQLRDIAEDLGEHYDWVGTGRAGGSKDEFAAVFYDVRRLAPVEYDHFWLSDTPYLIGSATWGNTVIRMVTWVRFRDLRNGSEFYALNTHLDHAHQYARERSAGLITERLHGLDAALPRIVTGDFNVAAHKNPVYEAMLDGGALVDSWDTAERRSAQYATFHGYQPLVRDGDRIDWILTSPGVRTRRAAINTYSAHGQFPSDHLPVQAWVEW
>NZ_CP019457.1|WP_033270947.1|178840_179092_+|DUF2277-domain-containing-protein
MCRSIKTLRPPTTPEVTDEDIRAAALQYVRKVSGFRAPAAHNREVFDHAVDAVTAATRELLDNLQVRGGAPRQEVLPPRQETS
>NZ_CP019457.1|WP_077194541.1|178055_178736_+|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MHPAPRTAPAAPLPARREIAPGAVHVPGWLSLTQQRELVTACRGWARGPAPIRHTKLPRGGVMSVQTVCIGWHWQPYAYTRTADDVNGARVAAFPSWMVELGRRALVEAYQDAGAGDGYTPDTALINFYDGQAKLGMHQDKEERSAAPVVSLSIGDTCVFRFGNTETRTKPYTDVELASGDLFVFGGASRFAYHGVPKVHPGTGDPATGLASGRLNITMRVTGLPG
>NZ_CP019457.1|WP_099872434.1|176855_177041_+|hypothetical-protein
MSPTPSAHPRLPSPASEANESIRRFVRARRGLAWTSQDMAEYAVLLEIWTLAVRAEVVEAA
>NZ_CP019457.1|WP_077191266.1|176250_176622_+|VOC-family-protein
MRPRFSLATVVLDCPDAHALAGFYRALLGWEMKLSEADWVLLRNPEGGTGLSFQSEPGYRPPVWPELPEEQQKMLHLDIRVDDLDEAEAYAVALGAVRAAWQPQDDVRVLLDPAGHPFCLFLA
>NZ_CP019457.1|WP_079271242.1|174737_175997_+|serine-hydrolase
MSVPPTGHRRVRLAATATAALLALTVPTAASAASTTGRPSSSGAAAHPDRAGLDRAALSRTLKAFHDAGMYGAYSAVRDGTEEWQGAAGVADVDTGRPATPQMRHRIGSITKTFTAVAVLQEVAKGRIALDAPIGRYLPDLVPGQRGRTITVRMLLNHTSGIGEYSPAIFPTLESIEANRFHQFDPRELARLGLAAKPTGKPGQAHHYANTNFVLAGLLLRKVTGQSPEAYITDHVIRKAGLRHTSFPRSPHLTGPHAKMYEAAYGFFQPPRDFSVYNMSWAGTAGSLVSTMPDLNRFFHALLGGELLPAAQLRQMKTTVPIEGSKMRYGLGLFEMPLPCGKVWGHNGLVPGAMTWSLSTADGRRQMSLGFNLTRYQKLNAHGEAQLGPIDTAMDAHLLQAMCGTAGHFRPEAFGDLRR
>NZ_CP019457.1|WP_033271021.1|174224_174461_-|hypothetical-protein
MDYPERYELVFQAPAVEDDVVVVRRTERAGAGGFPVYEDESGIVRAEISDRGEVRMLASGGHQMLRTPMLARPLAPGP
>NZ_CP019457.1|WP_143686383.1|173744_174044_+|hypothetical-protein
MSRTELERLARIRMQVTGETLERAMAVLAGHPTTPDSEPEPETAPPAGLGADADEQGEQPDGADTSETTPEGGPAPGTGRSAGPDTVHPPRRRSHLRGL
>NZ_CP019457.1|WP_143686385.1|183477_183867_+|hypothetical-protein
MLDERVVVRPVRFRESQPESVGAHVLGEASHVQPVGAGAEDQQAPQQRTPEPRRFLPCLLEPTVLQREGVFTGCRPLVSKGRHFAKLQCRLMTARCGVPPRGLGDAFQTKAGRENLLRQEAGLSQMIRT
>NZ_CP019457.1|WP_077191270.1|183985_184984_+|GNAT-family-N-acetyltransferase
MGVNSGNGHGSLGRLPSYLFRPYRGNEDHGAMAAVRLGCAGRDGIDARSIVEGVPTAAEIGEASAKLDDPSENQVLVEHNGDIVGYVTIRWWQERDGTWLYLHRGYLLPEHRGAGIGSDMVDWAESRIRRLVQQHGTARTAVFGANAMVSEEDSTELLLEIGYRRVFSLVELELADLRRLPEHNGQLPAGIRVGAVEPTSYHAAWKTVVDSYANVAFTEKWTFESFLATADPTCWRAAWDEDRMAGVALCSIHRHDHTVGEVEELSVRAESRRLGLGRALLLDGLRSLREHGAETARLYTGTANPHRSYDLYKSVGFRRQNEYVRYRKPIDV
>NZ_CP019457.1|WP_107431023.1|185383_186517_+|IS30-family-transposase
MTNKEASRRVGVHDRTGREWRNGRTDPKRRRAPALAEQEPVPSATRYLRDDERIHIADRLREKASVRTIAAELGRSPSTISREIRRNGMPLRGDHTRWVYRPHAAQRRADRRRPRPKPRKIGQNNELRDFIQAHLAMRWSPEQICHALRRRFPGRPEMHVVHETIYQALYVQGRGELRRELARALRTGRARRKPHRQAASRQPRFSHPMVMISDRPAEADDRAVPGHWEGDLIIGKDGASAIGTLVERATRYVMLVHLPGGRGADDVSTALQTTVQALPRHLTKSLTWDQGSEMAAHHAFTVATDIPVYFCDPASPWQRGSNENTNGLLRQYFPKGTDLSAHGPEQLVAVAAELNSRPRKTLDWETPAERLHKLLTV
>NZ_CP019457.1|WP_077191271.1|186687_186786_-|3-oxoadipate-enol-lactone-hydrolase
MSEKTLQHRIDGPDDAPVLVLGAALGPTWHRL
>NZ_CP019457.1|WP_077191272.1|187176_187821_-|TetR/AcrR-family-transcriptional-regulator
MAETVRPGRAKRVATLPPRERILDAAEELFHSEGIRGVGVQAVAERAGTTKAALYRHFGTKDELVAQWLRIVAADYVSAFDAVEERWPDDPRAQIKGVAAFVVDTLSTLSHRGCPFVNSLAELPDRTHPARQVIEAHKARQLRRLTAMCTAAELIDPEGAAAELTFALEGAQVSAQNGSVDHIAERLTTFVESLLVWHGAKGSPDPSGSPSHHS
>NZ_CP019457.1|WP_077191273.1|187973_189425_+|amidase
MELSEYVTYDAVGLAELVARGEVAGAELKAAALEAVAAVNPLINAVVETWPAERAEEEGAGEGAPLAGVPFLLKDLGVSMAGKRVELGSRLAKGNVASADSYLMRRFRESGLVTIGRTTTPEFAYGITTEAVLYGPTRNPWDLDRSPGGSSGGSAAAVAAGIVPIAHGTDAAGSIRIPAASTGLFGLKPTRGRVSMGPDVDEIFNGLAVQGGISRTVRDSAALLDRIQGPESGDPYFAAPPDRPYSEEITRPPGRLRVGVIAQGGGRRRTEGAVLDALSRTAELLASLGHHVQEATLDPGVSWEQFVGANAQLWTANLVPWLDALAAASGRPIDPSTVQTEVLASYAWGRQVTGADFVSALGVRNTVARSIGRHFDRYDVLLTPTLPELPPRLGVYAEAVEELDGLGWIDRIFDRSPFTACFNVAGTPAMSVPLTADPATGLPIGMQFAAAYGREDTLFRLAAQLEEAAPWSHRVPAVWAGSH
>NZ_CP019457.1|WP_077191274.1|189594_190086_-|hypothetical-protein
MSLSFEPPQPYDLGTDADLGMWLAEWAEWPEYADRIVHHGPDDGRNHGQLCWDVLAPTGLLAPHCGHCEHGPGGPRNPQKVESALGIRIPPDQLLSWTAATLIRELVHPSRDGPMRLVAHAIANGVIALLGPDADWRANGYAAYREGANGNVSWAAVTEAGAT
>NZ_CP019457.1|WP_159031792.1|190280_190862_+|hypothetical-protein
MDHEEWRPFLKLWSEEWIVGHDPERDAPLHDDVVRDGWLGFAPASADEVVAAEARLGRTLPPSLREFLLTTNGWQDAGNFIYRLAGTSELAWLADTDEGASWIDAYNDTEFADEDEEPEGDILARSLCLSLDGDAAVLLLDPEDVDERGEWAGYWLASWSGRGPERFGSFYDLMRHQYTSFRRLRQPEGKSGS
>NZ_CP019457.1|WP_159031793.1|193724_194282_+|hypothetical-protein
MRAHLFLPTVKFAPPVSVAPGRVARSVLIGMFATTPHLRKMFPDLANDLQHRRPHITMSDGATLRMAMYPSRSTRLASMAYGMRVLTHRQHYNIFSEIYFRPLAWTLSPSDDRLDGAGLGESVLRSWPVVDEWLRYGDDVAALDLRDLCRRGIPTVGHPLREGRGEWIETFQNDTAAFLEGKIPA
>NZ_CP019457.1|WP_077191277.1|195113_195839_-|peptidylprolyl-isomerase
MRRTLMTALAAAALIVSGSGTTASASDAPPRTTHGPCQYTQTPDEPAARPVPLPPDPRQTPSHGTVGMAVRTSQGPLSLRLDRAKAPCTVQSFVHLARHRFYDRTVCHRLTAYPTLKVLQCGDPTSTGEGGPGYKYKDELPVDLPPAPSDPTGVRRLYGRGLLAMANAGPNTNGSQFFVVYGDSALRPNYTVFGTVGAAGLKTLDKIAAGGIEPTAQDPAPVDGTPVLRTELLSVRPSCLP

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Crispr_ID: NZ_CP019457_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_2

329972-330068

Orphan

Consensus_repeat	Method
GCCAACACGAGTTGGCCAACAAGCGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_2

>merge|NZ_CP019457|2|329972-330068|CRISPRCasFinder
GCCAACAAACATAGGCCAACACGAGTTGGCCAACAAGCGTTGACAGTCCAGAGCCGCGGCCCTACGTTTGCCAACACGAGTTGGCCAACACGCGTTG

>NZ_CP019457|2|2|329972-330068|CRISPRCasFinder
GCCAACAAACATAGGCCAACACGAGTTG	GCCAACAAGCGTTGACAGTCCAGAGCCGCGGCCCTACGTTT
GCCAACACGAGTTGGCCAACACGCGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_077194556.1\|338818_339439_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP019457.1\|WP_077191343.1\|332314_332767_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077194555.1\|335893_337654_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379501
NZ_CP019457.1\|WP_077191335.1\|325326_325677_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP019457.1\|WP_033268842.1\|322718_323069_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226318
NZ_CP019457.1\|WP_077191336.1\|326164_326722_-\|DNA-binding-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077191334.1\|324413_325238_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213021
NZ_CP019457.1\|WP_077191340.1\|330175_330526_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NZ_CP019457.1\|WP_077191332.1\|320252_320807_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380121
NZ_CP019457.1\|WP_033268856.1\|339630_340593_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176229
NZ_CP019457.1\|WP_079271254.1\|321363_322707_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|227277
NZ_CP019457.1\|WP_077191346.1\|337739_338399_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP019457.1\|WP_077191342.1\|331301_331730_+\|DUF4267-domain-containing-protein	unknown	unknown	gnl\|CDD\|372907
NZ_CP019457.1\|WP_077191341.1\|330631_331018_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP019457.1\|WP_051733453.1\|319462_319690_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033268852.1\|332012_332315_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|316153
NZ_CP019457.1\|WP_033268848.1\|329389_329971_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NZ_CP019457.1\|WP_033268847.1\|328160_329057_-\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270704
NZ_CP019457.1\|WP_077191333.1\|323490_324417_-\|NmrA-family-NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|187561
NZ_CP019457.1\|WP_107430904.1\|333857_335441_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_077194556.1\|338818_339439_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.15137e-13
NZ_CP019457.1\|WP_077194555.1\|335893_337654_+\|hypothetical-protein	gnl\|CDD\|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	1.51382e-14
NZ_CP019457.1\|WP_077191335.1\|325326_325677_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	2.62203e-28
NZ_CP019457.1\|WP_033268842.1\|322718_323069_-\|hypothetical-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	8.04064e-31
NZ_CP019457.1\|WP_077191334.1\|324413_325238_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213021	cd10916, CE4_PuuE_HpPgdA_like, Catalytic domain of bacterial PuuE allantoinases, Helicobacter pylori peptidoglycan deacetylase (HpPgdA), and similar proteins. This family is a member of the very large and functionally diverse carbohydrate esterase 4 (CE4) superfamily. It contains bacterial PuuE (purine utilization E) allantoinases, a peptidoglycan deacetylase from Helicobacter pylori (HpPgdA), Escherichia coli ArnD, and many uncharacterized homologs from all three kingdoms of life. PuuE allantoinase appears to be metal-independent and specifically catalyzes the hydrolysis of (S)-allantoin into allantoic acid. Different from PuuE allantoinase, HpPgdA has the ability to bind a metal ion at the active site and is responsible for a peptidoglycan modification that counteracts the host immune response. Both PuuE allantoinase and HpPgdA function as a homotetramer. The monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of polysaccharide deacetylase (DCA)-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. However, in contrast with the typical DCAs, PuuE allantoinase and HpPgdA might not exhibit a solvent-accessible polysaccharide binding groove and only recognize a small substrate molecule. ArnD catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.	3.60561e-66
NZ_CP019457.1\|WP_077191340.1\|330175_330526_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	4.86803e-09
NZ_CP019457.1\|WP_077191332.1\|320252_320807_+\|hypothetical-protein	gnl\|CDD\|380121	pfam18143, HAD_SAK_2, HAD domain in Swiss Army Knife RNA repair proteins. Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.	0.000834469
NZ_CP019457.1\|WP_033268856.1\|339630_340593_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176229	cd08268, MDR2, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	3.65145e-96
NZ_CP019457.1\|WP_079271254.1\|321363_322707_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	3.71735e-141
NZ_CP019457.1\|WP_077191346.1\|337739_338399_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00238279
NZ_CP019457.1\|WP_077191342.1\|331301_331730_+\|DUF4267-domain-containing-protein	gnl\|CDD\|372907	pfam14087, DUF4267, Domain of unknown function (DUF4267). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.	1.63657e-23
NZ_CP019457.1\|WP_077191333.1\|323490_324417_-\|NmrA-family-NAD(P)-binding-protein	gnl\|CDD\|187561	cd05251, NmrA_like_SDR_a, NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs. NmrA and HSCARG like proteins. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.83813e-50
NZ_CP019457.1\|WP_033268852.1\|332012_332315_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	2.82763e-23
NZ_CP019457.1\|WP_033268848.1\|329389_329971_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	9.08091e-26
NZ_CP019457.1\|WP_033268847.1\|328160_329057_-\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|270704	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase. This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	4.82082e-77
NZ_CP019457.1\|WP_077191341.1\|330631_331018_+\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	5.63288e-60
NZ_CP019457.1\|WP_107430904.1\|333857_335441_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	9.85627e-23

>NZ_CP019457.1|WP_033268848.1|329389_329971_-|TetR/AcrR-family-transcriptional-regulator
MTGTTENQQAARRSDATRATILAAARERFAADGYEKVTIRAIARDAKIDPSMVMRYYGNKAGLFAAAVAIDPGLPGLPVEPREEIGRTLVRHFLTLWEENEELTALMRVGATDPAAAERMQSVLREQLIPLARRLGPEPDQAPARAALCASTVLGLALTRYVLRFPASMALGREEIVDWLGPTVQRYLTAPTP
>NZ_CP019457.1|WP_033268847.1|328160_329057_-|aminoglycoside-phosphotransferase-family-protein
MTDTEIEITADLVRDLLQEQHPDLAGLAIREVAGGWGNQMWRLGDELAVRMQRMDPTAELQLKERRWLPVLAPRLPLPVPTPVRFGEPSERFPKHWTVMTWVPGEPLDHGSISRGAHAADTLAGFLRALHVEAPAEAPIATDRGAHPKNCTDGFENFFQAVALDDIAADVRAVWDDAVAAHAWEGPRVWVHGDLHPANVVVSDGTLSGIVDFGDMFAGDPAWDLAAAWVLLPAGTASRFFDMYAHADEAAIRRARGLAAMKSLFLMLMGQNGDRGLPGGKPNWGPAGRAALDRVLKGV
>NZ_CP019457.1|WP_077191336.1|326164_326722_-|DNA-binding-protein
MGILGDSLDKATDATTTRPIPKSAGAQMRFLVKQHKGSTKAVAQLLGISRRTVERYAKDQIRRPRRELAARIEREVRKRWQPKVRQKAQQRASSTGEIVIETRARFGFTAAPGTTDDGRIRLITQHLPPAYAARLFDAQASGATEQQLQNIAAEGLQEIYFKDRGRRADGLMVEFTDIDYVELDF
>NZ_CP019457.1|WP_077191335.1|325326_325677_+|helix-turn-helix-transcriptional-regulator
MREYSGSVFLADCPARLAIEITADKWAVVVLFALSREPCRHGELVDLIGGISRKVLTQTLRRLQGYGLVDRHAEAGKVEYVLTDLGRTLVKPIAVLTEWAHEHGAAVVGFQESKKD
>NZ_CP019457.1|WP_077191334.1|324413_325238_-|polysaccharide-deacetylase-family-protein
MTAETEWPGGRKVVALVTVALEMWSPGHWPAYAPMAAAWPLSGIDDTHSTSWADYGVTTGIWRLLDVLGDLPATVGVNGLVAERYPETVMAVHEAGHEIAAHSWAQDVVPALLDVDAERTNIRRCTDILRRVTGVRPTGWMSPRATGSRHTAGLLAEAGYRWTGDHCDHDLPQVLSTAHGPLVSLMHSDYSDVRDAAAGPYAYRDLHRELLDQMLAAPGPGIFRLTIHAHVGGRPLLAGMVGQILDHIRESGDVWVATHAQVAEHVLTHQGRTP
>NZ_CP019457.1|WP_077191333.1|323490_324417_-|NmrA-family-NAD(P)-binding-protein
MTHVLVVGGTGAMGSHVIPHLLATTDATITVPTRHPESARATELAATAPDRVRLVRSESAALEVLLGQADRVFANTDFFATGSAVGEYRQGLHLLAAAERAGVERFIWSSLDSAVSLTGHPVPHFDSKAAVAAHIDLMRSEEMLRKETDGWYTDHVSVLTTAPYFENLRDRLTPRPDGRGGLTFRLPLGAARYPLVALDDIAWFVGHMFDNWQSWGARDLAVIGDSLTGDEIAATFAQVTGTPSTYIPMPHDDLRAAVPDFGHDYVAMFQFFADRDLYARDRDIKLLRRLHPDLMTFEDWLHRTGWTG
>NZ_CP019457.1|WP_033268842.1|322718_323069_-|hypothetical-protein
MKYMLLINAGAVDENGAAAECSVEDWVTYDKEVKDAGIWVSGESLADLVTATAVRVGQDGRRTVTDGPFAESREVLGGFYVIDVPDLDVALDWAARCPGARGSGSVVVRPIAEFGV
>NZ_CP019457.1|WP_079271254.1|321363_322707_-|RNA-polymerase-sigma-factor
MEDEGVTGRGIPVASARQSPAHASACASVESVFREERGRLLASLVHHFGDLDLAEDVASEAVEAALAHWPAEGVPARPGAWLLTTARRKAVDRLRRDQAYAARLAVLQVEADRAAAAPPPADAAGDLPDERLQLFFTCAHPALAAEDRTALTLRCLAGLTTPEVARALLVPAATMAQRIVRAKKKIRQARIPFRVPGADELPERLPGVLQVLYSIFTEGYAASSGPQLQRIDLAEEAIRLARILHRLMPAAREVDGLLGLMLLIHARHEARTGPDGELVLLEDQDRSRWDHTMIKEGYRLAVSALTGGPPGPYGVQAAIAALHDEAPDLATTDWPQVVALYDVLLALAPSPVVELNRAVAVAMRDGPQAGLALLDALAGEPRLRGHHPYPAARGDLLHRLGRLPEAAAAYQEALDLAGTEPERAHLRRRLHTIEPPGPGDRADKTST
>NZ_CP019457.1|WP_077191332.1|320252_320807_+|hypothetical-protein
MGRPLLFLDVDGPLNPYAAKPEKRPEGYTTLRVPQESGVAGEPGRVRTRRRPLRVWLNPDHGRALLTLNYEICWATTWMSDANKWIGPVLGLPELPFVDFGNALLSERPDGVHWKSEPLVEYANGRPFAWVDDEQSDADHEHVTANHRAPVLLHHVNPRIGLRDDDFTTLAGFAASIDMSTGSS
>NZ_CP019457.1|WP_051733453.1|319462_319690_-|hypothetical-protein
MRSREELAAFVRTLHQDFLQQGDAWENNTLATFLEALAAWVHDSPGFYQNFGKELPAGGDWTFIARALQAAKVYE
>NZ_CP019457.1|WP_077191340.1|330175_330526_+|antibiotic-biosynthesis-monooxygenase
MAKLQSLDPNTPMFAQFKEKTGPIVLANTFVVPKARTEAFLALFHRQAEFMKAQPGFVSLQMHKGTADSQLLMNVAVWESTEALATAFGRPEFQRMVAESPDDIVSYPHIFEQIDV
>NZ_CP019457.1|WP_077191341.1|330631_331018_+|VOC-family-protein
MTVELNHTVVPARDPQASAQFLADILGLSVDPPLAHFTPVTLANQVSLDYDQLDDFEPHHYAFMVSEEEFDAAFARIQDGGITHYADPACQENGQIYRSERTEGRRGTYFRDPDGHLMEILTPGGAGS
>NZ_CP019457.1|WP_077191342.1|331301_331730_+|DUF4267-domain-containing-protein
MSLKNVNTVLITAVTLFVLYLGLSFILAPEASTQGVGLPNWPAGNGKGFLIMKGTREFSMGLVIGILLMTGHRRALGWVLLMEAVAPFGDMINVLAHHGSLAAAFGIHGLTSALIAITGLLTLRETRKAHKAPAPAPAAQPA
>NZ_CP019457.1|WP_033268852.1|332012_332315_-|MarR-family-transcriptional-regulator
MDPDFDEFLHVPARLSVVALLAPADWVEFGFVRDKVRTSDSALSKQVASLAEAGYIEVRKTRNRTGRQTHVRLTSHGRLAFQRHAAALQRIVAAAHEPQE
>NZ_CP019457.1|WP_077191343.1|332314_332767_-|hypothetical-protein
MTSYDAQTALDAIHHHQEQTRDAYVRHGSSLPYILVTALAVFSFSASVDLPNPWRTLTLLTASGLMAGMLFVHQRRAPVRRKPSGAEWAFSLWVGGVVTVVLVAALIGARLLELPNPGVIAGAVAAIATLVSRYATRPIMKAITRRNSNV
>NZ_CP019457.1|WP_107430904.1|333857_335441_+|sigma-70-family-RNA-polymerase-sigma-factor
MDAENGVAVVTAAQNGDHRAQDELVGECLPLVYNIVGRALNGHADVDDVVQETMLRVINGLDSLRDPADFRSWLVAIAMNQIRQHWRQNQSRTAPLPGYDGLDDSLDIADPGADFVDATITRLGLEGQRRELAQASRWLDSDDTALMSLWWLEAAGELTRAEVAAALELSPQHVGVRVQRMKGQLETARVVVRALDSTRKAGPRACAELESMAERWDGAPSPLWRKRFSRHVRACASCSGHREELAPAEKLLVNLTLAPMTGTAAAALLEAVCAKADAGEAAARPAGGMTPLPAAEAGSFAGAAGPRTAHAPVRAGHRRGTGSRHRHGRHRIPHGRRAGRTTSTTALPVSLAGAAHPADRGRRRRPFAPRPAVALPSGHAASPAGQLVRTSGQSREETFRPAGRRPARPRANQDRPATAAHRPDAPAGAGVARRTCAPSLPRPHRPGRHRPRRADHRGGLFPERPGRQHRPPPAGPGESDERPEERHGAPPPRAHPHLYGRPAPASPAGRRGPCRTQHVSTQLTRFR
>NZ_CP019457.1|WP_077194555.1|335893_337654_+|hypothetical-protein
MVYKGLKPAPKSDSCVGVYKVVRSGLCTHGPDEPPKGVDIHRTTPPAVKASAPKPDLNSGDAHAPSSKDLLKDAPPVLDAQKDAGQQTAAAQAPAAGDGDRTAAAGGQQVVCDGDGATGNRVQVLYVHAPGQSRYGQYVASFKQWAAGADLIYAESAKETGGTRHIRYVTGSDCTPTVLDVELPASSLGEFSATNNALAERGYNRRDRKYMIFADAQVYCGIGSFAGDERPDASNQSNFGPSYGRTDSGCWSASTAAHELGHNLGAVNNSAPNTSRGAHCTDEWDIMCYSDTPYYPQMRTVCPERGHDERLDCNHDDYFNTAPRPGSYLATHWNVANNQFLIKGGSSPDPDPGPTAGPKPVVGTITADTASLSWQAVNSAASYDIVLNDQSIGSVTTAATRIVNLRPDTDYTVAIAVKDRDGHTSKPGPKTSFHTTSAGDPTKTITSGKPYALLNPLTGKAADLYGGSSADGTVLIGWQRHGYANQQWVFRDAGGGYLRIESVLSHKCLQVGGSLQAGAYVMQQPCSSAASQQWKTTASGSTWTLAPKGTDLLLGVSARDYYGGTLLELQRPDSRGQQNWTAQPVS
>NZ_CP019457.1|WP_077191346.1|337739_338399_+|hypothetical-protein
MRLRPRALCVPLLAFLASPLLVLVQAGQADAHGDSIQFTVTGQDTGHVRAKATYEDDHDPVDERISGTLTAVSADGRTRGPWRLVAVPGHAGTVTTQEVLPPGTWKVTVESGFPELGRGEGKIDVPVVDPRPGGKTTPRPARPTASGTASAAPSVEPATPATAHAAARAGAESGSGSGSGSGSEGATAWLPWTATAAAVLAVTATTVTAVRRRRRSRTN
>NZ_CP019457.1|WP_077194556.1|338818_339439_-|TetR/AcrR-family-transcriptional-regulator
MRSDARDNRARILDAARAVFGEEGLSAPMREVARHAGVGPATLYRHFPTKQALFAETFAEQRRACHAAVRDALTDSNPWHGFRGLIERICELHAHSRGFADAFMTAFPEAMDFAADQERTLHAVGELARRAQNTGQLRPGFVVDDLVLMLKAHRGLQDTPRAARVTASRRFAAYMIEAFRAAPETGAPTPLPPAPRLQLTYSPSTP
>NZ_CP019457.1|WP_033268856.1|339630_340593_+|zinc-binding-dehydrogenase
MKAVVIRTFGDPDGLEVVDVPVPVPAPGQVQIATEAIGVGGVDAVIRRGTLAAYGFREGHLLGSEVAGRVTAVGEGVDASWIGRRVWAFTGLSGGYAEHAVASVEDVLALPDGLTGADAVTLGGSGVVAHFALARASFTPGETVLVRGAAGSIGITAVQLAARDGASAVAVTTSSAERGARLRDLGATHVLDRSGEDGPDAPAGFDVVIDVVGGPQLPLFLDRLNSNGRYVAVGVVGGQPPADFGMRLMDAFRRSLSFATFSSDTVPGPDRQAVRSSQFADAAHGNLRTVVHQVLPLDQAVLAHREMDAGEVFGRVVLAP

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Crispr_ID: NZ_CP019457_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_3

1938872-1938975

Orphan

Consensus_repeat	Method
GTCCCCCCGCGCCGTTCCGGCGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_3

>merge|NZ_CP019457|3|1938872-1938975|CRISPRCasFinder
GTCCCCCCGCGCCGTTCCGGCGTGGGTGAGGTGGTGTCCGTCATGACGGTCCTCCCTGAGCAGGTCCGGCGCGAGGGGCGTCCCCCCGCGCCGTTCAGGCGTGG

>NZ_CP019457|3|3|1938872-1938975|CRISPRCasFinder
GTCCCCCCGCGCCGTTCCGGCGTGG	GTGAGGTGGTGTCCGTCATGACGGTCCTCCCTGAGCAGGTCCGGCGCGAGGGGC
GTCCCCCCGCGCCGTTCAGGCGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_077192042.1\|1943335_1944430_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|227940
NZ_CP019457.1\|WP_077192038.1\|1925368_1926763_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143456
NZ_CP019457.1\|WP_078617124.1\|1942932_1943334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377913
NZ_CP019457.1\|WP_051733002.1\|1936053_1936977_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
NZ_CP019457.1\|WP_099870078.1\|1945743_1946790_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_CP019457.1\|WP_077192044.1\|1947641_1951151_+\|exopolysaccharide-Pel-transporter-PelG	unknown	unknown	gnl\|CDD\|225153
NZ_CP019457.1\|WP_033267228.1\|1935323_1936073_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP019457.1\|WP_078617118.1\|1927863_1929168_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP019457.1\|WP_033267220.1\|1944898_1945714_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NZ_CP019457.1\|WP_077192043.1\|1946786_1947590_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213023
NZ_CP019457.1\|WP_077192039.1\|1926896_1927787_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP019457.1\|WP_033267229.1\|1933948_1935307_+\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|235421
NZ_CP019457.1\|WP_033267223.1\|1941068_1941875_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238861
NZ_CP019457.1\|WP_033267227.1\|1937154_1937466_+\|globin	unknown	unknown	gnl\|CDD\|367760
NZ_CP019457.1\|WP_077192040.1\|1930739_1932965_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239163
NZ_CP019457.1\|WP_033267222.1\|1942008_1942719_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|377734
NZ_CP019457.1\|WP_033267230.1\|1933137_1933800_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380058
NZ_CP019457.1\|WP_033267224.1\|1940532_1940796_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_159031825.1\|1939125_1940400_+\|DNA-methyltransferase	unknown	unknown	gnl\|CDD\|380119
NZ_CP019457.1\|WP_033267232.1\|1929168_1930605_-\|citrate:proton-symporter	unknown	unknown	gnl\|CDD\|225407

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_077192042.1\|1943335_1944430_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|227940	COG5653, COG5653, Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane].	1.19192e-39
NZ_CP019457.1\|WP_077192038.1\|1925368_1926763_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143456	cd07138, ALDH_CddD_SSP0762, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid, and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and other similar sequences, are included in this CD.	0
NZ_CP019457.1\|WP_078617124.1\|1942932_1943334_+\|hypothetical-protein	gnl\|CDD\|377913	pfam07760, DUF1616, Protein of unknown function (DUF1616). This is a family of sequences from hypothetical archaeal proteins. The region in question is approximately 330 amino acid residues long.	0.00228584
NZ_CP019457.1\|WP_051733002.1\|1936053_1936977_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.72539e-40
NZ_CP019457.1\|WP_099870078.1\|1945743_1946790_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	2.73256e-21
NZ_CP019457.1\|WP_077192044.1\|1947641_1951151_+\|exopolysaccharide-Pel-transporter-PelG	gnl\|CDD\|225153	COG2244, RfbX, Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only].	2.0839e-13
NZ_CP019457.1\|WP_033267228.1\|1935323_1936073_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	9.69e-44
NZ_CP019457.1\|WP_078617118.1\|1927863_1929168_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.34657e-31
NZ_CP019457.1\|WP_033267220.1\|1944898_1945714_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.21151e-45
NZ_CP019457.1\|WP_077192043.1\|1946786_1947590_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213023	cd10918, CE4_NodB_like_5s_6s, Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.	4.05556e-56
NZ_CP019457.1\|WP_077192039.1\|1926896_1927787_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	6.97697e-33
NZ_CP019457.1\|WP_033267229.1\|1933948_1935307_+\|homogentisate-1,2-dioxygenase	gnl\|CDD\|235421	PRK05341, PRK05341, homogentisate 1,2-dioxygenase; Provisional.	0
NZ_CP019457.1\|WP_033267223.1\|1941068_1941875_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	4.22615e-56
NZ_CP019457.1\|WP_033267227.1\|1937154_1937466_+\|globin	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	2.02151e-06
NZ_CP019457.1\|WP_077192040.1\|1930739_1932965_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239163	cd02762, MopB_1, The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP019457.1\|WP_033267222.1\|1942008_1942719_-\|DUF1275-domain-containing-protein	gnl\|CDD\|377734	pfam06912, DUF1275, Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although most members have 6 TM regions, and may be putative permeases.	3.20952e-25
NZ_CP019457.1\|WP_033267230.1\|1933137_1933800_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	2.12778e-15
NZ_CP019457.1\|WP_159031825.1\|1939125_1940400_+\|DNA-methyltransferase	gnl\|CDD\|380119	pfam18135, Type_ISP_C, Type ISP C-terminal specificity domain. This is the C-terminal domain of Type ISP restriction-modification enzyme LLaBIII present in Lactococcus lactis subsp. cremoris. Type ISP restriction-modification (RM) enzymes provide a potent defence against infection by foreign and bacteriophage DNA. This domain interacts extensively with DNA and is known as the target recognition domain (TRD). TRD works by recognising 6/7 base pairs of asymmetric sequence.	2.61041e-61
NZ_CP019457.1\|WP_033267232.1\|1929168_1930605_-\|citrate:proton-symporter	gnl\|CDD\|225407	COG2851, CitM, H+/citrate symporter [Energy production and conversion].	1.94841e-169

>NZ_CP019457.1|WP_033267227.1|1937154_1937466_+|globin
MTIEYIRYRITEPERRAAFEKAYTAAAEQLDAAPECLGYDLAHGVEEPERYILRIEWTSVEDHLKGFRGGPLFGPFLASVRPYIDDIEEMKHYAPTAVTSARR
>NZ_CP019457.1|WP_051733002.1|1936053_1936977_-|LysR-family-transcriptional-regulator
MEPELRQMRYFVAVAERRSFTRAAEDVYVAQQALSQQIKALEDTLGVRLLDRTSRRVDLTPAGAAYLADCKRLLSAAGRATQHARAVAAGEAGKVRIAYTVTAVYETLPALTAHLAERAPRLKVETREIFAADVCRMLRDERCDLALAPGTGYPNGIARQTVRREELRVAVRDGHPYAGAPAVELAGLRGETFQLWPREMAPGYYDAVAGACRAAGFEPVLDETASGSNAWAGIAAGRGVNLVVASLARQLPRGITLVPLAKPVPVLRIDAVWRAEHPHPAVPRVLAGCAELWPGETAGGAVSAPPG
>NZ_CP019457.1|WP_033267228.1|1935323_1936073_+|GntR-family-transcriptional-regulator
MTTFAPDSLDLNRKLPLWYQVSQSLRASILGRSPKDPLRLPTEDALAAHYGVSVLTMRQALKELEAEGLISRHRRRGTFIEPSAQRGAPVRLLGSVDAIVAQQSGMSTELLDHGPTAVPAELAEYFPELSEVGGFRRLRSDEETGEPTNHACNYVRPDVAALIDPQDLVRWPMTKVLRDAVGVRISRITDTVEARLADPETARLLRVPLLSPILHYTGVTYDEDGRPVDVARIHYRGDRFSFTVTLEAH
>NZ_CP019457.1|WP_033267229.1|1933948_1935307_+|homogentisate-1,2-dioxygenase
MAGTGNEQARKTAEGLAYATGFGNEHSSEAVPGALPVGRNSPQRAPLGLYAEQLSGSAFTEPRASNRRSWLYRIRPSAAHPPFVRGEQRALRSAPFTDCAADPNRLRWNPLPAPEGPTDFVDGLWTLGGNGDATQRTGMAVHLYHANASMERRVFSDADGELLIVPERGGLLLRTEFGLLRAEPGEVALIPRGVRFRVELLDAAPDGGPAPTARGYVCENYGRPFELPDLGPIGANGLANARDFRAPLAAYEDVEGPVEVVNKFCGNLWTATYDHSPLDVVAWHGSHVPYVYDLRSFNVIGSISYDHPDPSIFTVLTSPSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMTEYMGLIEGAYDAKTAGEGGFVPGGGSLHNMMSAHGPDRETFDRASAAELAPQKIDDGLAFMFETRWPLTLTEQARDAGHLQRGYDDVWQGLQRHFRL
>NZ_CP019457.1|WP_033267230.1|1933137_1933800_-|TetR/AcrR-family-transcriptional-regulator
MQQPPSRPAPPASDPGPPATPLRRAPVQRRSAQRLARILDACAEVLEETGYEDLSTRAVALRAGVPIGSVYRFFPNKRAMAEALARRNLDAYADRITARLTAVDEAPLEWRRAMDVVVDEYLAMKRTVPGFALVEFTVPAPRETRQANYLVADRLLALFAGPLGLDAADQRLRTAFLVGVETADALLQLAFRTDPAGDPAIVTEAKELLRAYLARYLDTA
>NZ_CP019457.1|WP_077192040.1|1930739_1932965_-|molybdopterin-dependent-oxidoreductase
MTRTALRICPLCEATCGLTVTLDGDRITAARGDRDDVFSKGFVCPKGASFGELDADPDRLTRPLVRRDGVLTDATWDEAFAAVQAGLRPVVEAHGPDAVAVVLGNPNVHTVAGALYPPVLLAGLRSRSVFTASTVDQMPKHVSSGLLYGDPLAIPVPDLDRTDHLLIIGANPMDSNGSLCTAPDFPGRIRALRRRGGRLTVIDPRRTRTAKLADEHLAIRPGTDALLLFAMVHVLFEEGLVDLGERAAHVVQADEVERLAAGFTPEAVAGPCDLPAASVRRLARELAAADSAAVYGRIGASTVEFGTLTSWLVDVLAVLTGNLDRPGGLMFPLSATGAAPRPAGPGRGFALGRWRSRVSGHPEAKSELPIAALAEEIDTPGEGRVRAAVAIAANPVLSVPDGDRLDAALASLDFMVSVDPYLNETSRHADVVLPPPPPSRGAHFDYAFNALAVRNQVRYTRPVLPLADGQPDECAIQARLILCLGGQDGADPALVDAMVIDTVLGKAVADPHSPVHGRQPDELAAQLTGRDGAERRLDMMLRLGPYGEGFGADPEGLSLARLLDHPHGIDLGPLTPRIPALLRTPSGAVELCPAPIAAEAERLRGRLGAVPDGLLLVGRRHLRSNNSWLHNVPTLMGGSNRCTLHVHPEDAARLGLTDGEPARLKGDGGEVEVPVEITDTVRPGVVSLPHGWGHDRPGTRLGVAAADPGVNVNQLNAGRLLDPLSGTAVLNGLPILLTPVR
>NZ_CP019457.1|WP_033267232.1|1929168_1930605_-|citrate:proton-symporter
MLTILGFVMIATFLVLIMMKKMSPLAALVLIPALFCVLVGQGAHLGDYVIKGIGDLAPTAAMLMFAIIYFGVMIDVGLFDPVVRGILRFCKADPVRVVVGTALLAAIVSLDGDGSTTFMITVSALYPLYKRLKMSLVVMTGVAATANGVMNTLPWGGPTARAATALKLDAGDIFVPMIPALAVGLVAVFALAYVLGRRERKRLGVLTLGDVATVTGTVEEKETEQVLVGAGAGAKGGAPAAARPATGGSAAPGSDGSGGSVQDLDLQGLDPRRPTLRPRLYWFNAALTVALLTLLILQTLPIPVLFLLGAALALTVNFPHMKDQKARIAAHAENVLNVSGMVFAAAVFTGVLTGTGMVEHMARWLVSNIPDALGPHMGLVTGVLSIPLTYFMSNDGFYFGIVPILAEAGAAHGVAPIEIARASLVGQALHMSSPLVPAVYVLVGMAKVEFGDHTRFTVKWAALTSLVVLGASLLFGIV
>NZ_CP019457.1|WP_078617118.1|1927863_1929168_-|MFS-transporter
MTATDTARPGRSWLLRLVLTFSFAQGAVSMARPAVSYRALALGADGRAVGVITAVYALLPLLVAVPLGRRTDHGRCAPLLVAGVALISGGCALSGLAGSLPAMAAWSGVMGLGHLCFVIGAQSIVARRSAPEDRDRNFGHFTIGASLGQLIGPVAAGLVISERDGRMAPTSATALLVSGAVAAFSYASLWRLERRGRPAPAGDRGRPAAAPVPVRGILRSRGVAAGIFMSLAVLSATDVLTAYLPVIGEDRAIAPTAIGLLLSLRAAATLACRLVMTPMIRWLGRTALMAGSCALAGLLCGGLVLPVPVWALAAMLAALGFCLGVGQPLSMTTVVQAAPERARSTALALRLTGNRLGQVAAPAGAGVLAGLAGTAAPFVLLGVLLLASAGLAARTGAERGGRSVAVAGGARGPTVAGGDRKPARRDRKRLRREP
>NZ_CP019457.1|WP_077192039.1|1926896_1927787_-|NAD(P)-dependent-oxidoreductase
MTHHTRTPVTVLGLGAMGRALAAAFLRAGHPTTVWNRTPGRADELVGRGAVRAGTVAEAVAAAPLVIVCVLDYAAVRAILEPVGAQLSGRTLVNLTSDTPERARAAAAWAAGHGIDYLDGSIMVPTPVIGQPDGTVLYSGSRDAFETYGATLKALGGRAPYLGEDHGTAAVYDLSLLGFFFSAMAGLVHAFALAGSEGVPAKEFAPFTETIVGILPALAAGMAEDLDRGVFSGDQDNLVMEAAGIGHVLEAARARGLNTEVLDAVKGIADRTIAAGHGNAGFVSVIEEMRRSSAKA
>NZ_CP019457.1|WP_077192038.1|1925368_1926763_-|aldehyde-dehydrogenase-family-protein
MKQHDAMYIDGSWRPAEGGGTIEVVDPADGRVIATVPAGSAADVDAAVRAARGALPGWAATPPAERADRLAALHEQLVGRAEEIAETVTAELGSPLAFSRAVHAGVPVAVCGSYAELARTFSFEERIGNSTVLLEPVGVVGAITPWNYPLHQVVAKVAPALAAGCTVVLKPAEDTPLVAQLFAECVDAAGIPAGVFNLVTGLGPVAGQALAEHDGIDLVSFTGSTAVGRRIGAAAGAAVKRVALELGGKSANVILPSADLAKAVAVGVANVMANSGQTCSAWTRMLVHEDRYDEAVALAAAAVAKYVPGERVGPLVSARQRDRVRGYIERGVAEAARLVAGGPEAPCAQGYFVSPTVFADVTPGMTLAQEEIFGPVLSLMKYADEDDAVRIANGTVYGLAGAVWAADEAEAVAFARRLDTGQVDINGGRFNPLAPFGGYKQSGVGRELGPHGLAEYLQTKSLQF
>NZ_CP019457.1|WP_159031825.1|1939125_1940400_+|DNA-methyltransferase
MPGSNRTVREGLRVTAKQDAPRLSDLMPWSVAPLRLGRSWVRAPDPATLRARWKALVDAEDAAARERLFRPSRARTLHSAVGQLPGQATATGRLYRASGPCPEPVRILHGPFDRQWLLPDHRLIDVARPELWRVADEHQLYAVEWGQVPQAPGPAVGCSALLPDGRSPAGRPGRIHPLYRRPGGREPNLAPGLLDLLTRHLGRPVGPSELLGWILASAGHSADGAVVPLTADPEVFGRGLALGERLLWLGTRGAGSGERPRMPGGRRPYVRSALPARGMPAALAYDAEDEALLLGSGRIAPVPAGAWDFHAGGVRVLEAWFAERAGTGADGASPPEDGSLAALRPADWPQEWTSELLELITVLALLAELEPSRVELAGRTADGPQLTADALRAAGVLPAPLAARRPASVLDHHEEGPDGQFALL
>NZ_CP019457.1|WP_033267224.1|1940532_1940796_-|hypothetical-protein
MEQITVRSRARVPAINCGSVASSARLDRHLAVLGGPAIPQREVEGATSLMQELTARDHARTRNGRGARVSLFAPLRRLRRSLFGGHG
>NZ_CP019457.1|WP_033267223.1|1941068_1941875_-|SGNH/GDSL-hydrolase-family-protein
MRLSRFAALTSAFFVTTALALTGASAAASAQLPTATGYVALGDSYSSGVGAGGYDSASGSCKRSTRSYPALWNAAHGPSSFAFTACSGARTGDVVSGQLGPLNASTGLVSITIGGNDAGFADTMTTCALQGESACLARVAQARTYIDNTLPGRLDTVYGAIAQKAPNARVVVLGYPRFYKIGGSCLAGLSDKSRTAINAAADDINGVTAKRAADHGFSFADVTTTFTGHELCSGSAWLHSVTYPVDESYHPTSAGQSGGYLPVFASAA
>NZ_CP019457.1|WP_033267222.1|1942008_1942719_-|DUF1275-domain-containing-protein
MEPPSGTALIVIMVGLTVATGVLDAVSFLALGQVFTATQTGNLLFLGFGIAGQGGLPVVATVVSLGAFVLGAALGARLESTLARHGRQWFPMALATEAALLACSALAAWESGSARGLPPGRRYAVIGLMAMAMGMRNVTALRAAAPDLTTTVETRAMTALVSGSLLGRDRRLGYGTHAGPRRLTSVGAMFGGGLLGAVLIGLGTRPMLVILLVAAFVAAVALLVPGMARRRAGADD
>NZ_CP019457.1|WP_078617124.1|1942932_1943334_+|hypothetical-protein
MNCDPPVSTPPPGTTSGLAALLTGAAWGSAAMGAVLTLADVDSPLRVPFTLFLLVGAPALSIGAALGRTSPLARAVVALAGALALDLLVAQAMLALHLWSVRGGTLAVAALSGAVLLLTALARARRARTGRAG
>NZ_CP019457.1|WP_077192042.1|1943335_1944430_+|GNAT-family-N-acetyltransferase
MDVTVQHPHELSGADRAAWTALQSAAPSQGAPQLANPFLAPEFALAVGRCRGGVRIAVIREDGRPAAFLPFHRSPLGVGRAVGLGVSDAQGLVHRPGFRWDARELLGACRLSVLEFDHLVDGQQPFHNTSLRPHASPVIDVDQGYEAYLERLRGQSPKFVRTTLAKERKLGRDVGPVRYVHDERDPEALRTLARWKSAQYRRTGRSDRFAQPWIVRLVRDLFHTRTDSFAGLLSVLYAGDRPIAAHFGPRTRSVLSCWFPAYDAELAKYSPGLVLHLRMAEAAAAASMAYLDMGRGKAEYKDSLKTRELRVAEGWVMRPHPVALGHWAYRAPVRALRNAVLARPELRDPADRLLKRVGRIRSGH
>NZ_CP019457.1|WP_033267220.1|1944898_1945714_+|glycosyltransferase-family-2-protein
MNSFLRPADADEPPLTLLPDHAVYRPVSSHLAIAPPVSVVIPAMNEAENLPYVFKTLPDWIHEVVLVDGNSTDDTVAVARELWPAVTVVTQRGKGKGDALISGFAACTGEIIVMIDADGSADGNEIVSYVSALVSGADFAKGSRFANGGGTDDMTPVRKLGNRVLTALVNAKFGARYTDLCYGYNAFWRHCLDHIALDCAGFEVETLMNIRVVKAGLRVQEIPSHEYNRIHGVSNLRAVRDGLRVLKVIAGERGARRKRLARPALITGDAL
>NZ_CP019457.1|WP_099870078.1|1945743_1946790_+|glycosyltransferase-family-2-protein
MRISVVICVHTEDRWEDILAAVASVRAQSHPAHELLLVVDHHQRLLDRLTEHFARAPGGARPPGPPPAPLRVLANAGPRGLSAGRNTGIAAADGEVIAFLDDDAVAERDWLRHFAAAYADPAVMAVGGRTEPVWESGRRPLWFPEEFDWVVGCTYRGLPAGKVRVRNVLGGNASFRRVAFDLAGGFTTGIGRDGDRRPLGCEETELCIRISQVLPDAVLLIDDRAVIHHRVPAERRRFRYFRGRAYAEGLSKALVARSVGARDGLAAERRHTVRVLPAGVLRGVRDALLGRPGGAARAGAIVAGAAAAAGGYAWGTVRARAKPTPLPPGPVDDPACGPAAAAHEGAPA
>NZ_CP019457.1|WP_077192043.1|1946786_1947590_+|polysaccharide-deacetylase-family-protein
MSGRPGAVPILMYHAITVAPTPAVRDLSVTPAAFEEQLAVLADGGFTPLTTTALATAWRGGGPLPPRPVLITFDDGYDGVYRHALPALARHGFPATLFVSTGWLRGPYGTGGAPDTTLDWDQVRKLAGAGVEIGGHSHTHPRLDALGDARLRHEVLRCKEIIADEVGAAPESFAYPFGHSSRRVRRTVRGLGFRQALAVGNTLAAHRQGPYALARLTVRRRTGTEEFARIVEGRGLARAFARDRALTKGYAVVRRTRQAVRLCLPDH
>NZ_CP019457.1|WP_077192044.1|1947641_1951151_+|exopolysaccharide-Pel-transporter-PelG
MSDTSTKATERAEREPRRGGRDGGSPLFRNAYALMLNTGVSGLLGLGFWLVAARCYTESAVGQGSAAIAAMKLLAGLAALTLTGALARFIPVAGHTTGRLVRRAYAASSVVVALAATGFLLTLDLWGPSYRFLHGFPNGLGFVLAVVAWSLLTLQDGVLTGLRSALWVPVGNLAFSTVKLGLLVVLAAAVPTAGVFVSWVAAIAVSVLPLGWLVFSRLVPRHVRRTEHTARPPSLRQTVRFLAGDSTGSLFSLAVVHLVPVLVASQVSATDNAYFYVTTTIGGTVNLLALNMGSSLTVEGAHDPAQLAHHTRAALRRMARIMLPVCLALFLFAPYLLDVFGAGYAQAATPLLRWLAVGAALRVVMEVHFAVLRAQSRTAGLAALQGLLCVLVLGLTLVLLPRMGLAGAGVAETASLAVIVALATVRLRRVLRGQVATAPLTRAPSDGLAPDGDLADLAVYGDLGDGAGTYGRAAPREAGPPAAVRPRRGPRPPGTRRRRGRHRALAGWALLAAGLALFWLPLRGMGDADLDRMNGLGLLSVLPAATLAGVVVLVAAFAWALSLPGARRALPAAVLLMTVVALHALPAVLESEPRFPTAWQHLGFLDYLGRTGTAVPDLDARWSWPGFFAGVRFLAGACGVTDFTEVLRWWPLTLQLLYLAPLFLLLRAVRASRRAKWCAAWLFALCGWVGQDYFSPQGFTYLLYLVFVAILLVWFRGARPHTGRLRPGEAEPPPAGRDRRTVLLTTLIALFAASVAGHQLTPFVMLGVLTALVLVRRCTLRGLPLLLAVLVAAWVGFLAEPYWSGHFDELFGGLGGIGGNVSSSVTDRIGGGDATHKVVLYARVALAGGVLTLACWGVLRRRAAGFAERSLPVLTFVPFLAFGMQSYGGEMALRVFLFALPGACVLAALALFPHVPGAARPGTGAARRALGPLAALLTGLVLAVGFLVARWGNEPFERIRPGEVAAMNYVYAHDRPTARLLWLSNDPVNSVTPAMPWGARDMERVQYAPTLAPRDPAGVGPLVTALRDAGPQSYLVVNHGQAEALRLDSGYPAGWEARLRTALDRRPELRRVLSNEHAAVYEVGRRPAGEVPLPRPGPAGPKVTWTPWSVLGGLALLALIAVLTAREVLRVAMAPGPRRAHWTQGLFWFAVPLLLVFVASLVQRFLTLS

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Crispr_ID: NZ_CP019457_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_4

2782958-2783061

Orphan

Consensus_repeat	Method
TGCTCTGCCAATTGAGCTACAGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_4

>merge|NZ_CP019457|4|2782958-2783061|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGACCGAGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGCTGCTCTGCCAATTGAGCTACAGGGGA

>NZ_CP019457|4|4|2782958-2783061|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGA	CCGAGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC
TGCTCTGCCAATTGAGCTACAGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_033268660.1\|2791113_2792427_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NZ_CP019457.1\|WP_077192365.1\|2788550_2789549_-\|threo-3-hydroxy-L-aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|235918
NZ_CP019457.1\|WP_077192364.1\|2786563_2788480_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP019457.1\|WP_033268672.1\|2777870_2778902_+\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237564
NZ_CP019457.1\|WP_077192361.1\|2780942_2781818_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133029
NZ_CP019457.1\|WP_077192363.1\|2785185_2786433_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP019457.1\|WP_033268666.1\|2783279_2783579_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033268669.1\|2780266_2780629_-\|DUF861-domain-containing-protein	unknown	unknown	gnl\|CDD\|380395
NZ_CP019457.1\|WP_033268665.1\|2783676_2785146_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP019457.1\|WP_077192358.1\|2774100_2775762_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP019457.1\|WP_033268670.1\|2779580_2779973_-\|thioredoxin	unknown	unknown	gnl\|CDD\|239245
NZ_CP019457.1\|WP_033268757.1\|2793400_2794393_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NZ_CP019457.1\|WP_077192359.1\|2775932_2776931_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|153418
NZ_CP019457.1\|WP_077192367.1\|2792423_2793302_-\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP019457.1\|WP_079271648.1\|2794445_2794970_-\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|377602
NZ_CP019457.1\|WP_033268676.1\|2773207_2773831_+\|DSBA-oxidoreductase	unknown	unknown	gnl\|CDD\|376526
NZ_CP019457.1\|WP_077192362.1\|2781896_2782478_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP019457.1\|WP_077192366.1\|2789558_2790824_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP019457.1\|WP_077192360.1\|2777050_2777680_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033268671.1\|2778972_2779569_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_033268660.1\|2791113_2792427_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP019457.1\|WP_077192365.1\|2788550_2789549_-\|threo-3-hydroxy-L-aspartate-ammonia-lyase	gnl\|CDD\|235918	PRK07048, PRK07048, threo-3-hydroxy-L-aspartate ammonia-lyase.	3.7128e-158
NZ_CP019457.1\|WP_077192364.1\|2786563_2788480_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP019457.1\|WP_033268672.1\|2777870_2778902_+\|rod-shape-determining-protein	gnl\|CDD\|237564	PRK13930, PRK13930, rod shape-determining protein MreB; Provisional.	2.00881e-125
NZ_CP019457.1\|WP_077192361.1\|2780942_2781818_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.41288e-18
NZ_CP019457.1\|WP_077192363.1\|2785185_2786433_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	1.94227e-162
NZ_CP019457.1\|WP_033268669.1\|2780266_2780629_-\|DUF861-domain-containing-protein	gnl\|CDD\|380395	cd06990, cupin_DUF861, domain of unknown function DUF 861, cupin domain. This family contains proteins which seem to be specific to bacteria and some fungi. The function of this family is unknown but contains a cupin domain without a metal binding site. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).	1.1229e-57
NZ_CP019457.1\|WP_077192358.1\|2774100_2775762_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	2.67604e-85
NZ_CP019457.1\|WP_033268670.1\|2779580_2779973_-\|thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	6.69632e-34
NZ_CP019457.1\|WP_033268757.1\|2793400_2794393_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	9.17638e-155
NZ_CP019457.1\|WP_077192359.1\|2775932_2776931_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|153418	cd07377, WHTH_GntR, Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators. This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.	3.09765e-17
NZ_CP019457.1\|WP_077192367.1\|2792423_2793302_-\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	2.17227e-25
NZ_CP019457.1\|WP_079271648.1\|2794445_2794970_-\|gamma-glutamylcyclotransferase	gnl\|CDD\|377602	pfam06094, GGACT, Gamma-glutamyl cyclotransferase, AIG2-like. GGACT, gamma-glutamylamine cyclotransferase, is a ubiquitous enzyme found in bacteria, plants, and metazoans from Dictyostelium through to humans. It converts gamma-glutamylamines to free amines and 5-oxoproline.	6.23803e-20
NZ_CP019457.1\|WP_033268676.1\|2773207_2773831_+\|DSBA-oxidoreductase	gnl\|CDD\|376526	pfam01323, DSBA, DSBA-like thioredoxin domain. This family contains a diverse set of proteins with a thioredoxin-like structure pfam00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyze one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs, whose similarity to HCCA isomerases was not previously recognized. Some members have been annotated as dioxygenases, dehydrogenases, or putative glycerol-3-phosphate transfer proteins, but are most likely HCCA isomerase enzymes.	2.52083e-11
NZ_CP019457.1\|WP_077192362.1\|2781896_2782478_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.04606e-09
NZ_CP019457.1\|WP_077192366.1\|2789558_2790824_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	8.58842e-71
NZ_CP019457.1\|WP_033268665.1\|2783676_2785146_+\|sugar-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	1.4706e-115
NZ_CP019457.1\|WP_033268671.1\|2778972_2779569_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	8.80934e-57

>NZ_CP019457.1|WP_077192362.1|2781896_2782478_+|GNAT-family-N-acetyltransferase
MQLLSFPEAATPPDLRAQVRELHDEAWPPSDPPADHDSDTGHDPALHPRSMLLVDDGTVLAALDILSKPLVHAGQHYRAGGLSTVVTRQAARGRGHGRRLVAAAREAMSRSGLDLGVFTCDRPLRSFYESAGWQLLPGTVLVGGTPTAPFPSDRPGFDKVTMADFFSTTARESRTAFRHTRLELHPGEIDKLW
>NZ_CP019457.1|WP_077192361.1|2780942_2781818_+|glycosyltransferase-family-2-protein
MPHLRVGVAVLTMGNRPAELHALLDSVAKQDLQPVHVVVVGNGSPLPSLPHGAHGVELSENLGVSGGRNVALDELRKLGDVDVVVDLDDDGLLISPDVLRRVAELHEREPELGVISFRIADELGRTQRRHVPRLRVGDPRRGGPVTTFLGGGHSLSMAMLDRIGDWPEDFFYAHEETDLAWRALDDGWRIRYESDLVLQHPYTSPTRHAVYHRMVARNRVWLAKRHLPAVLVPLYLGVWAVLTAVRSRSAAGLRAWAAGFAEGVRTPCGRRRPIRWRTVWRMTRLGRPPII
>NZ_CP019457.1|WP_033268669.1|2780266_2780629_-|DUF861-domain-containing-protein
MMEVKTIDKPDERRDFPRGHLEALHLTGLDFAVATFEPGWRWSESVGPIAGTDSCEVHHNGFMVQGRMRIRMDDGAESEVGPGDVFVCPPGHDAWVVGDEQVVVYDFAGGMAVGYAKAKE
>NZ_CP019457.1|WP_033268670.1|2779580_2779973_-|thioredoxin
MSTVELTKENFDDIVSGNDFVLIDFWAEWCGPCKQFGPVFERSSEKHDDLVFAKVDTEAQPELAQAFQIQSIPTVMIVRDNIAVFAQPGALPAEALEDVIGQARALDMEEVRASVTEAQQDEQAQAEQAQ
>NZ_CP019457.1|WP_033268671.1|2778972_2779569_-|histidine-phosphatase-family-protein
MSELLLVRHGETEWSRNGRHTSWTDLPLTANGEEQARALRPLLSDRKIGQVCASPRARALRTAELAGLPEPEIDPDLREWDYGGYEGIATAEIHRERPGWYLFSDGVPPGPEGHPGESPDEVGARADRVLARLTPYLDADDGDVVLVGHAHFSRVLAARRLGLPASAGGLFTFETGAVCVLGTEHDRPAVVAWNARSL
>NZ_CP019457.1|WP_033268672.1|2777870_2778902_+|rod-shape-determining-protein
MTISLAQLRRCSAAVDLGAARTRVYVKNQGLVVDEPTVAAVNTRTGALLAVGAQAEVMDGRTPDYIRVVRPVSGGTVVDIDMAQRLLRTLVGDKLRKTWRRRPTMRAAVCLPYGSEPLAQRAAVETLTGLGARRVELVDTLVAAAIGSGLPVEQPEATMIVVCGAGTTQVAVLSLGSIVAAETVQVGGNAIDHAVIQHLRLHHELMLAGQAVRPLQLILSGGDGRTPGSTEVHGRDVVSGMARSVHVDTERVLDAITTPLTAILDGIGAVLRRCPPDLVADLGERGIMLAGGSALIPGLEPMIHQATTMPVHTADRPDTCAVMGLGAMIEGKVQPLHLDPMAP
>NZ_CP019457.1|WP_077192360.1|2777050_2777680_+|hypothetical-protein
MNPTADNDPPTGAGAPTGPGASADLPGPVAFQCVLLRRMADHHPGRVEDALRALGVTRAQMREANRRWQATMHTPRGRGVQPYRALLGAPESLTTRRIGDLTCKVLTWPVPLWPDLRFEVLTDERRGTVWNAWLVRAPGAAAPELRTAPDLAPWCCTVDEVARAFAPARPLEGSAPTRWRLACTAPGPDGTPEKLVAEFTWGLYQRRVD
>NZ_CP019457.1|WP_077192359.1|2775932_2776931_+|GntR-family-transcriptional-regulator
MEQSAPPPYRRIVEEIRRRIDTGELAPGDRVPSTRRITREWGVAMATATKVLTTLRQEGVVQAVPGVGTVVSDPQAGPPDQPQTRARKPARGAPAPERTPREPDGGGLNRDRIVSAAVKVADAEGLRGLSMRRVAAEFGMSSMALYRHVANKDELVLLMADAAFADVTLPDPAPDGWRERMEAGARLQWELYQRHPWLAQYLSLTRPQPMPRAMALIEWTMARVEGMDPVTLIHMALTLLGFVLSTAAGLEDDLEAEQETGMDQEQWMAAMDPVFEGILTSGSYPMYAGMAGTDDDKVNLGTLFEFGLERLLDGMEVLVERRAGGAATVRTP
>NZ_CP019457.1|WP_077192358.1|2774100_2775762_-|MFS-transporter
MPFTSYTSRPCASQPSAGRREWIALAVLLLPCLLVSMDVSVLYFAVPFLTAQLEPSSVQQLWILDVYGFVLAGLLITMGALGDRVGRRKLLLSGALLFGLASGLAAYSGSAEMLIAARALLGVGGATLMPSTLALIRNLFHDAKQRGKAVAIWSAAMMGGIAIGPVLSGALLEHFWWGSVFLINAPAMVLLLVCGPLLLPEFKNPAAGRFDLPGSLLSLLAMLPLVYGIKEIARDGVSALPVVALAAGLLAAAAFVHRQRTARHPMLDLELFRHRGFSVSVLMNLLAMFAVVGCAVFFTQYLQTVRGMSPLEAALWNLLPTLAVGGMTAVATSLAQRMDRAYVIALGFAIAAGGFVWLSWLEPGSALWYVLVASSVYASGLVMVMSLGNELAIGVAPPERAGSASALLESGTELGGALGMAILGSIGSAVYRGHMDDAVSAGLPSGAADAARETLAGAAAVAGELPGRAGEALLAAARIAFTDGLQTAVLVAAGVMALAAALTIALLRGLRTTEGEGPNGAGTGDAAAAADAAGVTGAGAAGVADVAGAGTGI
>NZ_CP019457.1|WP_033268676.1|2773207_2773831_+|DSBA-oxidoreductase
MTNPSSTRHSVDFYFDPICPFAWISSRWILEVEQHRDLDLRFRVMSLSVLNEGREDLPQKYRELLDAGWGPVRVCIAAAQEHGEGVLRDLYTALGTRIHNDGREDTATVIEEALAEVGLPAELAGAADSEAYDDALRKSHHEGMDPVGEDVGTPTIHIDGVAFFGPVLMAIPRGEDAVRVFDGARLLAGYDKFFELKRSRTGEFDFS
>NZ_CP019457.1|WP_033268666.1|2783279_2783579_+|hypothetical-protein
MRYRLTFMAGLATGYVLGSRAGRERYEQIRKAAQRVTRNPAVRNSAESVALTGRDAASKAFGKVSAKVEGHLPASVGSRVRSLREQRASTEDEWGTSNT
>NZ_CP019457.1|WP_033268665.1|2783676_2785146_+|sugar-kinase
MDSSSDSTRIVVCDADTGAVIRQGYAPHPVEKGPEADPQAWLMSLGEAAGGGLLEGVQAIGVSAQQHGLLVLDADGNLVRPALLGNDRRAQSAAADLVDSLGGRTAWAQAVGAVPQAAHPVTKLRWLARTEPENAARVTEVMQPHDWLVWQLLGRPARRTTDRGAASGTGFWSAASASYRPDLVELALGHQVRLPEVLGPSGTAGFTPEGLLISAGTGETMAAAFGLGVGEGDAVVSLGASGSVFGIHHEALVDPSGTITSFADATGRHLPVVHTSNAVRVLRGAAEMLGTDLQGLSDLALKSSPGAYGMVLLPYLEGERTPHLPHTAGSLHGMRRESMKPEHMARAAVEGMLCGLADALDVLRGRGVAVRRVFLLGAAAELGAVQAAAPGLFGVQVVVPQPADYAALGAARQAAWAWGVAHGTLAPAAGAEAGPGGGSVWVDPPQWPAAASQVFEPGEELPVGQAVRQQYATVRDEIHPGAWADRREG
>NZ_CP019457.1|WP_077192363.1|2785185_2786433_-|RNA-polymerase-sigma-factor
MPESSERGGSGRTPPETPAEPLSMYGTDGGSAATVPGLSAASAAITLEVAPVQSQTLADAPAAAEPADEPAPEPVTVVQQAEPPAAELLLEEIPQEPAAAPDPGPAPRAETGSPSSDLFRQYLREIGRIPLLTAAEEVDLARRVEAGLFAEEKLTNTPDLSSQLAYDLDQLVVLGRMAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTPEEVAAHLDLTEERVSEVLRLAQEPVSLHAPVGEEEDVALGDLIEDGDAASPVESAAFLLLREHLDAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD
>NZ_CP019457.1|WP_077192364.1|2786563_2788480_-|DNA-primase
MAGRINDDDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFHVSPAKGLYHCFGCQEGGDTVDFVMKIDHLSFAETIERLASQAGITLRYEEGGYSPGRQQGERTRLVEAHKAAAQFYAEQLDSPEAEIARAFLAERGFDQAAAQHFGVGYSPAGWDHLTRFLRGRRFTDQELVLSGLSQEGRRGPIDRFRGRLMWPIRDIAGEVVGFGARKLRDDDNGPKYLNTPETPLYRKSQVLYGIDLAKKEIARTNRAVVVEGYTDVMACHLAGITTAIATCGTSFGEGHIKILRRLLMDNSGSEVVFTFDGDAAGQKAALRAFEDDQKFAAETSIAITPGGMDPCDLRLAKGDQAVADLVESRTPLFEFALRHVVSRHNLDTTVGRAAALDEAAPIVAHIKNSSIQHESAVQLAGMLGILDTQFVVKRVAQLARWARERGRDGRPDQNRGPQRRPASAPEQARPAPGPRGPALNLRSPAHRVERELLKLALQRPDLVSPAFDAYGADEFTAPPYAVVRQCIEDAGGATAGASDDDYVARVREAAPDDTVRAMVTELTVEPLHTRRGPDEAYAGVQLVTVRLAAVNQRVTEIRGTLQRLGPRADPEHLAAVQNELWVLQQYGQSLRERGYAAL
>NZ_CP019457.1|WP_077192365.1|2788550_2789549_-|threo-3-hydroxy-L-aspartate-ammonia-lyase
MTQRTGPAHPGGDAPDLVTFDDVRDAARRLAGVAHRTPVLRSRTLDAAVGAEVHLKCENFQRVGAFKFRGAYNALSRLSPEQLARGVAAYSSGNHAQAVALAARELGSHAVIVMPEDAPRSKTDATAGYGAEIVRYDRYTADRAALAQQLAEERGLALVPPYEHPHIIAGQGTAALELLEETGRLDALLAPIGGGGLMAGSATAATALAPDIRMIGVEPEAGDDTRRSLAAGHPVTIPVPRTIADGQAVDTPGALTFAINRRLLDSVVLVSDDEIRAAMRFAFERLKIVTEPSGASALAALLAGRVSPLPARIGVIISGGNIGPDRFTELLG
>NZ_CP019457.1|WP_077192366.1|2789558_2790824_-|FAD-dependent-oxidoreductase
MVDAHQTFVIVGGGLAGAKAAETLRSEGFTGRVILICDERDHPYERPPLSKGYLLGKEERDSVFVHEPAWYAQAHIELHLGQPAVHLDPDAKTVRLGDGTLIAYDKLLLATGAEPRRLDIPGTGLAGVHHLRRLAHAERLRGVLASLGRENGQLVIAGAGWIGLEVAAAARSYGAEVTVVEAAPTPLHGILGPELGGLFTDLHREHGVRFHFGARFTEIVGQDGMVLAVRTDDGEEHPAHDVLAAIGAAPRTALAEQAGLDLVDRAAGGGIAVDAALRTSDPYIYAAGDVAAADHPLLDTRLRVEHWANALNGGPAAARAMLGQDVSYDRIPYFFSDQYDVGMEYSGYAPPGAYAQVVCRGDVAKREFIAFWLADDGRLLAGMNVNVWDVAENIQQLIRANHPLDPIKLADPEVPLTALLP
>NZ_CP019457.1|WP_033268660.1|2791113_2792427_-|deoxyguanosinetriphosphate-triphosphohydrolase
MTGTSPTIPGYTPADTERWVPEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGAHTHAWDATPRTRLTHSLECAQVGRELGAALGCDPDLVETACLAHDLGHPPFGHNGEQALNEVAASCGGFEGNAQSLRLLARLEPKRFVSAPGGTVLSVGLNLSRAALDAATKYPWPRGGHPTDPGSRKFGVYEDDLPVFGWFRQGTPDGAQSFEAQVMDWSDDVAYSVHDVEDGLHAGHLDPNVLLADPERAEIFAVAAERYAPGAGDAELAAALDRLLEQEWWPHGYDGSALAQARLKDATSQLIGRFCLAAEAATRVRWGSGRLTRYGAELVVPAETRLECAVLKAVADRYVMQRPDQEALRADQRIVIAELAEALLARAPDGLDPQFRSLFDAAPDDTARMRAVIDQIAALTDLSARSLHARLTRRPGNAEANPG
>NZ_CP019457.1|WP_077192367.1|2792423_2793302_-|sirohydrochlorin-chelatase
MTAPIPHPSAPSSAPLGAGDLAAEITAQLSTRLRTVRLHGFHRPGPAAPTLVAVAHGSRDPRALPTVRALLDRVRALRPGLPVRLGHLELDRPLLADTLAELSGRAVLVPLLFGHGHHVTHDLPAALAAAPHLTGRIAEPLGPHPLLAEALHGRLLEAGATAGRDWTAVVLAAAGSRAARSARDTERTAALLSACLGGLPVVPAYASAATPSVPDAVRELTARGHERIAVAGCFTAPGRFATQCAQAAPGAAAAPLGDHPALARLVLHRYDQALLTRTGSDPESTRAATVAV
>NZ_CP019457.1|WP_033268757.1|2793400_2794393_-|adenosine-deaminase
MPKAELHLHIEGTLEPGLAFALAERNGVTLPYATEDELRRAYSFSDLQSFLDLYYALMAVLRTEDDFADLAHAYLARAEEQGVRHAEIFFDPQAHTARGVPVGTVIGGLARALDSAEETYGISTRLIMCFLRDETAESALATFEAARPYLDRITAVGLDSAEVGHPPSKFEAVFRLAKEAGLKCVAHAGEEGPPAYVWEALDVLGVDRIDHGVRSMEDERLVARLAAEQVPLTVCPLSNVRLRVIDDLADHPLPAMLEAGLLVTLNSDDPAYFGGYVDDNFTAVRDALGLDPATLRTLARNSFRASFLDEAVREKYLKEVDAHEAGAHRE
>NZ_CP019457.1|WP_079271648.1|2794445_2794970_-|gamma-glutamylcyclotransferase
MTPEPERLPFFVYGTLCPGGTNHAWALRGRTAREEPARITGALLYDGPGYPYAVAGPPEAVVHGALVLPREADYDEVRATLDRLEGYAPGDPANLYERVATEAVRTDGSTEPAWVYLAAEPLAGRLRSTGTPVEGGAWRGAAAAGGHAPANLDDPSRTDGPSCPEGPSRTAEQV

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Crispr_ID: NZ_CP019457_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_5

3770659-3770786

Orphan

Consensus_repeat	Method
TGGACAACCACCAGCCCATCATCGGGGCCGGCGTCACGCCGCAGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_5

>merge|NZ_CP019457|5|3770659-3770786|CRISPRCasFinder
TGGACAACCACCAGCCCATCATCGGGGCCGGCGTCACGCCGCAGGTGCAGAAGCCGGGCGACCGGGATGTCGTCAGGCCCATGGACAACCACCAGCCCATCATCGGGGCCGGTGTCACGCCGCAGGTG

>NZ_CP019457|5|5|3770659-3770786|CRISPRCasFinder
TGGACAACCACCAGCCCATCATCGGGGCCGGCGTCACGCCGCAGGTG	CAGAAGCCGGGCGACCGGGATGTCGTCAGGCCCA
TGGACAACCACCAGCCCATCATCGGGGCCGGTGTCACGCCGCAGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_077192720.1\|3756327_3757233_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176231
NZ_CP019457.1\|WP_077192724.1\|3765963_3767196_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NZ_CP019457.1\|WP_077192731.1\|3779884_3782488_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NZ_CP019457.1\|WP_033269628.1\|3773242_3773836_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424
NZ_CP019457.1\|WP_077194767.1\|3764862_3765771_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NZ_CP019457.1\|WP_077192725.1\|3771162_3771357_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033269618.1\|3757468_3759040_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP019457.1\|WP_079271414.1\|3754658_3756182_+\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|213987
NZ_CP019457.1\|WP_077192727.1\|3773900_3775493_-\|fatty-acid--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|236072
NZ_CP019457.1\|WP_077192722.1\|3760813_3762553_-\|D-aminoacylase	unknown	unknown	gnl\|CDD\|238622
NZ_CP019457.1\|WP_033269632.1\|3778063_3778621_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077192723.1\|3763889_3764687_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP019457.1\|WP_077192721.1\|3759306_3760770_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143408
NZ_CP019457.1\|WP_077192729.1\|3777291_3778053_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP019457.1\|WP_077192730.1\|3778816_3779866_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP019457.1\|WP_033269621.1\|3762641_3763766_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP019457.1\|WP_077194768.1\|3776788_3777295_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224462
NZ_CP019457.1\|WP_033269624.1\|3767455_3770389_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP019457.1\|WP_077192726.1\|3771552_3773106_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|171961
NZ_CP019457.1\|WP_077192728.1\|3775600_3776752_+\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181147

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_077192726.1\|3771552_3773106_+\|AMP-binding-protein	gnl\|CDD\|171961	PRK13295, PRK13295, cyclohexanecarboxylate-CoA ligase; Reviewed.	2.78932e-107
NZ_CP019457.1\|WP_077192724.1\|3765963_3767196_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	7.51087e-30
NZ_CP019457.1\|WP_077192731.1\|3779884_3782488_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.69999e-71
NZ_CP019457.1\|WP_033269628.1\|3773242_3773836_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	4.8522e-36
NZ_CP019457.1\|WP_077194767.1\|3764862_3765771_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	6.54609e-65
NZ_CP019457.1\|WP_077192728.1\|3775600_3776752_+\|lipid-transfer-protein	gnl\|CDD\|181147	PRK07855, PRK07855, lipid-transfer protein; Provisional.	0
NZ_CP019457.1\|WP_033269618.1\|3757468_3759040_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	5.59729e-26
NZ_CP019457.1\|WP_079271414.1\|3754658_3756182_+\|PHP-domain-containing-protein	gnl\|CDD\|213987	cd07432, PHP_HisPPase, Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.	2.9668e-16
NZ_CP019457.1\|WP_077192727.1\|3773900_3775493_-\|fatty-acid--CoA-ligase-family-protein	gnl\|CDD\|236072	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP019457.1\|WP_077192722.1\|3760813_3762553_-\|D-aminoacylase	gnl\|CDD\|238622	cd01297, D-aminoacylase, D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.	4.82852e-93
NZ_CP019457.1\|WP_077192723.1\|3763889_3764687_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.44811e-74
NZ_CP019457.1\|WP_077192729.1\|3777291_3778053_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.87576e-37
NZ_CP019457.1\|WP_077192721.1\|3759306_3760770_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143408	cd07089, ALDH_CddD-AldA-like, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.	0
NZ_CP019457.1\|WP_077192720.1\|3756327_3757233_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176231	cd08270, MDR4, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.37868e-98
NZ_CP019457.1\|WP_077192730.1\|3778816_3779866_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	7.30098e-11
NZ_CP019457.1\|WP_033269621.1\|3762641_3763766_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	2.13793e-40
NZ_CP019457.1\|WP_077194768.1\|3776788_3777295_+\|hypothetical-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	5.61033e-17
NZ_CP019457.1\|WP_033269624.1\|3767455_3770389_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	6.7282e-39

>NZ_CP019457.1|WP_033269624.1|3767455_3770389_+|tetratricopeptide-repeat-protein
MDDGPGRERLRFTVLGPVRAWRGATPLAAGSPQQRALLAALLLRGGRTATAPELVDALWGDEPPHAALAALRTYASRLRKALGADAEALVSESGGYAIRPVDGHPLDLDHDHAEQYAAEAEKAKASGDRARARELLDAALDLWDGEPLAGLAGPYAETQRTRLEEWRLSLTETRLELVLEAGCHADAVSELTALTAAHPLRERLRELLMLALYRSGRQAEALAVYADTRRLLADELGVDPCASLSELQQRILQADPDLDAPDVSFDTDPAGPAVVRPQQLPATVADFTGRASFVSELGDQLATAEGSVMAVSALTGIGGVGKTTLAVHVAHAARDHFPDGQLYVDLQGAGDNPSEPVAVLGAFLRALGTPDASIPDGLAERSALYRSTLAGRRVLALLDNARDASQVRPLLPGMEGCAALVTSRARMIDLAGAHLIDLDVMSPEEALALFTRIVGEERVTSERQAAMAVVGACGFLPLAIRIAASRLAARRTWTVSILATKLADERRRLDELRAGDLAVKATFELGYKQLEPAQARAFRLLGLADGPDISLAAAAAVLDMDVDDTEELLESLVDTSLLESAAPGRYRYHDLVRLYARACAERDEHPPSERDAAMSRLLDFYLASAARMYALERPGDRLIVHMEATSYPGLAFADRAAALEWLFNEAGCLLACARQSSGAATLRRAADLLLLTKDLAESGADALQYEQANVALLTAAREAADQHAEARFHLALTYVRTLSGRLDEADENARSAMLLGLASEDPYVAASAPNDRGIIANAQHRHADAEGYLRQALTAFRDDNNRQSEASALCNLSRVHLDTGRVDSAIELAEEGLAIYRQLGAKRRLANGMYALALAYTQAMRLDEATGQLTAALAIFRDSRQRFWEGMTNFRLAEVELAARRPATAANHAEQALTALRGIGGDSWRATVLTTLGRALHALGQTGRARVCWQEALATFERLGSSEGNAVQALLTPTAVA
>NZ_CP019457.1|WP_077192724.1|3765963_3767196_-|amidohydrolase
METFPKIISVDDHTVEPPNVWRDRLPSKYHDIGPRVVRAPLKEMTFVGGKFAPKMGAPGDDGPIADWWIYEDLHRPLTRLDTAVGYSRDEIKLEGITYEQMRPGSYSVPERLADMDVNHVQSALCFPTFPRFCGQTFTEAKDRELGLLGVRAYNDWMVEEWCGPQARGRLIPLTLIPLWDPELAAAEVRRNAARGVRAVCFSEIPPHLGLPSVHTDHWDPFLRACDETGTVIAMHIGSSSRMPSTSADAPPAVGSTITFANCCFSMVDWLMSGAFDRFPRLKIMYAEGQIGWIPYILERADVVWEENRAWGGVADKVLRPPSELFADHVYGCFFDDAFGLRNLDAIGPGNVLYETDYPHSDSTWPKSREVGESQMAHLPPATVERIVRGNAIDLLGLTAEGLWEPSAPRG
>NZ_CP019457.1|WP_077194767.1|3764862_3765771_-|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase
MQLPVQAQSVLFAEGWEAAAGVADLVAVARAADRYGFAYIGCCEHIAIPRRLAEAMSTVWYDPVATLAYLAAATERVRLLSHVAVVGLRHPLISAKQYATLDHLSGGRLILGVGAGHVPEEFAALGIGFEERGAVLDETVDALKAALGSEEFPAFAGKRFAFEGLGQAPRPAQTPRPPIWVGGSSAAAVRRAAERGDGWLPQGDRREALPGQIARLRAMREAAGVREPAVIGAIAEPVYVGEPGWDVGRRALTGPPERIAASLREYGAMGVTQIQVRFRSRSRAELTDQMAAFGTDVAPCLN
>NZ_CP019457.1|WP_077192723.1|3763889_3764687_-|SDR-family-oxidoreductase
MGKLDGRVVLITGAARGQGEREARLFAGEGARVVLADVLDAQGEALAKEMAEEAGEGRAVYVHLDVGREEDWAAAVTSAKDAFGKIDGLVNNAGILRFNELTSTPLAEFQQIVQVNQVGAFLGIKTVAPEIEAAGGGTIVNTASYTGVTGMAYVGAYTATKHAIVGLTRVAALELAAKGIRVNAVCPGAIDTAMSNPAQLDPEADTEAAAQALDELYRKLVPLGRVGRPEEVAALALFLSCEDSSYITGQPFVIDGGWLAGVSVL
>NZ_CP019457.1|WP_033269621.1|3762641_3763766_-|LLM-class-flavin-dependent-oxidoreductase
MEFGLFVQGYVGKRAETDPLAEHKALMEETEYVIQADTSGFKYAWASEHHFLEEYSHLSANDVFLGYLAHATERIHLGSGIFNPLAQVNHPVKVAEKVAMLDHLSEGRFEFGSGRGAGSHEILGFLPGITDMNHTKEIWEETIAEFPKMWLQEEYVGFQGKHWQLPPRKIFPKPYGASHPAMWYAAGSPSSYAMAARKGLGVLGFSVQKVSDMEWVLEQYKTAIRDAEPVGDFVNDNVMVTSTAICAETHEKAVEIAVNGGLNYLQSLVFRYHDTFPRPDGIPEWPELLPDYTTEIIELLIAEELMICGDPDEVLRQCKRWDQAGADQLSFGLPIGIPYEDTMNTIKLIGEHVIPKIDTDPVHRTTRFRQTAGS
>NZ_CP019457.1|WP_077192722.1|3760813_3762553_-|D-aminoacylase
MLDHLIKGATVVDGTGAPAYAADVGIRGGRIAVIAAPGTVTEESATSEDAHGRILAPGFVDPHTHYDAQLFWDPYATPSLNHGVTTVAGGNCGFTLAPLHPDRPEDADYTRRMMSRVEGMSLVALEEGAPWSWNSFGEYLDALDGRIAVNAGFMVGHCALRRYVMGPDAVGGQPTEQQMAQMLALFHEAMDAGAWGLSTTQSGTHSDGDGQPVASRHATPAELLALSRAVAEHEGTQIEAIVAGCLDQFSDDEIELFVEMSAAAGRPLNWNVLTIDAAVPERVPRQLVASERARKAGGRIVALTMPILTPMNMSLGTFCALNLIPGWGEILGLPVDERIARLRDPAVRTEMLRRATSKEAGVFRRLTDFGRYVIGDTYSAANDGLTGRIVKDIAAERGQEPFTCLVDICANDRLRTVLWPMPTDNDPASWALRAETWQHQDVLLGGSDAGAHLDRMCGAPYTTRFLGDCLRGRRLVGLEQAVEMLTDDPAQLFGLRERGRVQEGYHADLVLFDPETVDAGKATLVHDLPGESPRLDSKAIGVHAVWVNGVETLRDDEVTGAVPGTVLRSGRDTRTVSTR
>NZ_CP019457.1|WP_077192721.1|3759306_3760770_-|aldehyde-dehydrogenase-family-protein
MTGAEGRLFVGGDWVAPAGGHYEVIDPATETVVGLAPEATRAQVHEAAAAARAAFAAWSGTAPEERAAILDRAADVLQRDFAAHAELAQAESGATTGTARALQVAVAVARFRRYAKGALEPVEQGLPPQVNEAGPMGRAGVIGALAARRPVGVVTCITSYNNPWANPAGKVAPALAMGNTVVVKPAPQDPLSVYRMAAALEEAGVPPGVVNVVSGASADAGAAAVDAPDVDMVSFTGSTAVGQRIGEVCGRAMKRQLMELGGKGAAVVFDDADLDAAVAGIGTTFSFYSGQICTAPTRVIAQRGVYDALIDRLARYAGHLKVGDPRAPGTVVGPVISAAHRDRVASYVELGRKEGARLVTGGEHPRGPERGFYVAPTLLADCTPDMRVVREEIFGPVVVVVPFEEEDEAVDLANDSDYGLIDYVWSGDVARAFRVARQLRAGGVGVNTVGRNMEAPFGGFKKSGVGRDVGSYALHAYSELQAIVWQG
>NZ_CP019457.1|WP_033269618.1|3757468_3759040_-|APC-family-permease
MVQVDPRPQAGDTVTSVAATGSADGTRGKGLSGNSVGLLGSAVIGISTVAPVYCLTSTLGPTVGEVGVQMPAVFLAGFLPMLLVAFAYRELNKAVPDCGTSFTWTVKAFGPRVGWMCGWGLVIATIIVLSNLAGVATSFFYLLLGELTGSQAIADLDGNRAAHVLTCLAFIAVATAISYRGMTATKGVQYTLVGLQLAVLAVFVVMAVAKAQSGDLAGSLHFSWTWLDPFAVRSFSAFTAGLSLSIFMFWGWDTCLTVNEETTGSAKTPGRAALLAMLVLIGSYLLTAVASQMFSGVGHKGTGLGNPDTADNVFAALANPVMGTVLGVLLFVAVLASAAASLQTTFIPVARTVLAMSTYEALPASFAKIHPRFRSPGRATIAAGVATGVFYAVMSILSENVLIDTIYALGLMICFYYSITAFACAWFFRRELRNSARDLLFKGVFPFLGGLLLAAVFGKTLTDMWNPAYGSGSSVFGVGSVFVIGVGLLLLGVVIMLIMRRRSPAFFRGEVLTRATPALVVEE
>NZ_CP019457.1|WP_077192720.1|3756327_3757233_+|zinc-binding-dehydrogenase
MRALVVDHSAPGRLALGTVADPEPGPDEVLVRISAISLNYGELPKSDDVAEGTVPGWDAAGVVERAAANGRGPKPGDRVITWGRVAGWAELRAVPVDELAVLPDAVDFTAAAALPVAGLTALRALRTAGVRPGQRVAITGASGGVGRFAVQLAHQAGAEVYAFVGSPARGAGLAELGADRVLTDPAGLDEPVDVVLDNVGGSLLGELLGRTAPEGTVISIGATSGEPTPIQPYQLILGRLRLIGIQAGGNTGADLAHLVRLVAEGRLEASVDRVADWEQAGKTATALLNREIRGKAVLTLG
>NZ_CP019457.1|WP_079271414.1|3754658_3756182_+|PHP-domain-containing-protein
MERRDVLKLSAVAGATGALTLGRVSFADAAPTAGQSGGGPGEQTRRVTGHLPPGAPDFVYLPVDVPHGVRELAVSYSYDRPAVPEGTAGNACDIGIFDERGTDLGGAGFRGWSGGARTEFFLRADEATPGYLPGPVNAGTWHITLGPYTVAPQGLSYDVTITLRYGPRGRTPAPVHPPERARGRGRAWYRGDSHLHSVHSDGKRTPAQIAALARAAGLDFLNTSEHNTISSHRAWEGLWGDDLLILTGEEVTTRNGHVVAMGTDPGVFIDWRYRARDNAFGKYARAIRRAGGLVIPAHPHATCIGCNWKFGLNDADAVEVWNGPYTPDDEVTLAEWDNTLVAHTHGRGDWLPAVGHSDAHRDPDVVGLPQTVVLADDLSRRALQDGIRAGRVWIAESSKVDLAFSVTGERGEHAGIGERLAVPDTTQVTARLKVTGAPGCTVSFVTDQGRLYTSPLPPSGEGTVSWQTTPAYAAYIRAEVRHPATTAGLPGPMAAMTNPVFLGTWGS
>NZ_CP019457.1|WP_077192725.1|3771162_3771357_+|hypothetical-protein
MTRTAKGLVVTAAAVAALGTAALPAVADSHSPTPPHSAMTLDNHAPVPPADKHTPLTPLDNHIP
>NZ_CP019457.1|WP_077192726.1|3771552_3773106_+|AMP-binding-protein
MFEAARVQTLWELVEYRARASRGAPMFFDADGRSVTFDGVRDEALRVAAGLRELGIGAGSRVAWQLPSRIGTVLVSLALARLGAVQIPVIPLHREREVGFVLAESAAEYVLVPGVWRGFDHTAMARKVAADGVRVVPVEDGLPRADPAGVPAVAPAEGTTWIYYTSGTTAAPKGVEHTDATLLAGGVGLATALGMSARDIGSIAFPYAHIAGPDYVIAMLVSGFPAVILDSFEPGRAADVYRRRGVTMAGGSTAFYQAFLDESRRRRAGRPGAGRLIPSLRLLSGGGAPLPPELCTAARRELECAIVHGYGMTECPMIAMGTPYDSDEQLARTVGRPVVGAEIRIVRPDGSGAATGECGEVTLKGPMLFRRYTDPALTAAAFDAEGYFHTGDLGLLRPDGHLVLTGRLKDIIIRKGENISAQEIEDLIHTHPAVAEAAVIGLPDRERGERVCAVITPADPAAPPLALDALTAHLRAAGLMTQKLPEQLESVGELPRGGPLNKVLKSVLRERYARGTR
>NZ_CP019457.1|WP_033269628.1|3773242_3773836_+|TIGR03086-family-protein
MTEMIDFTAQTRLVARLAERTADAQLDAPTPCGTYAVRHLLGHLVGLSAAFQDVARKELGPTTSTSPNAFRPDVEPGWRAELDRNLAGMVTAWRAPEAWEGETQAGGVPLPGAVAGRIALNELVLHGWDLARATDQDYAPDEDSLEVSYALLSSWAAADGTNGGLFGTAVPVPEDAPLLDRVVGLGGRRPDWTPSAA
>NZ_CP019457.1|WP_077192727.1|3773900_3775493_-|fatty-acid--CoA-ligase-family-protein
MHGDEDPRADLEYGTLPRLVRAAARRYGSREAVVEGRTRVSYAELGERVERAAAACMAGGVEPGDRVAVWAPNTLDWIVSALGAVTAGAVLVPVNTRFKGAEAAHVLDRTRAKLLFVTGTFLGTSYVASLRRAAPGLPHLEQVVVLSDSAPEGYRTWKDFLAGGEGITGEEVRRRADAVAPTAPSDIIFTSGTTGRPKGAVITHAQTLRCYGVWSELAGLREGDRYLIVNPFFHTFGYKAGIVACLLRGAVMVPQPVSSVETALANIAAERISVLPGPPTLHRSLLDHPARSAHDLSALRLVVTGAAVVPLQLVERLHAELGVRTVLTAYGLSEASGIVTMCRRGDAPEVIASTSGRAIPDTEVRVLAAPGEPGEVLVRGHHVMGGYFEDPEETAQVLDADGWLHTGDVGVLDAAGNLRITDRIKDMFIVGGFNAYPAEIEQLLCRHPDIAEAAVIGIPDPRLGEVGRAYAVRRAGSSLTADDLIAWSRREMANYKVPREVAFVTELPRNAGGKVLKTHLRKGLPGPARA
>NZ_CP019457.1|WP_077192728.1|3775600_3776752_+|lipid-transfer-protein
MGATLKDATAIAGIGQTPFAKHLPESEKTLACRAIVAALDDAGIAPSEVDAFASYTMEETDEVEIAKAIGAGDVTHFSKVGYGGGGSCATVAHLAAAVATGQASVGVAWRSRKRGSGPRPWKNTRVQLPTPGQWTRPFGLLRPADEIGLLARRYMHEYGATRDHLFNVALACRNRANQNPAAIMYDRPLTREMYMTARWISEPLCLFDNCLETDGALACVVVSAERARDCRQRPVYVHSAAQGLPAQHHGMVNYWNDDPLTGPAWTAARHLWKGADLGPQDVDVAQIYDAFTPLIPLSLEGYGFCGRGEGAAFTEGGALEIGGRLPLNTGGGGLSEAYVHGFNLITEGVKQLRGTSTAQVPDAATCLVTAGEGVPTSALLLRS
>NZ_CP019457.1|WP_077194768.1|3776788_3777295_+|hypothetical-protein
MTPSVPESLSASVPGTTDNAPGDDAGLLLPVPDEDGAPFWDHAARGELRVQSCSDCDELRFPPRPCCPHCQSFASHWRRMSGRGRIWSYVLPHPPLLPAYAALPGYNAIVVELAEAPRIRLVGNLVAAPDAPLNSVDPARLRIGAPVKAVFTKLPGGVTVPRWLLERP
>NZ_CP019457.1|WP_077192729.1|3777291_3778053_+|enoyl-CoA-hydratase/isomerase-family-protein
MTVRTRIADGVALVTLDRPDRHNAIDLDTAAELAATWRAFRFDDSVRAAVVTGAGGRAFCTGLDRSADVPQPPSPYSLDDPLLSIGPKTNDLWKPVIAAVDGMACGGAFYLLGEAEFIVASENSTFFDPHTTYGMVSAYESVLMAQRMPLGEIARLSLMGTAERLGARRAYQIGLVCELTAPGAAAEVALRRAATVAAQPTSAVQGTVRALWAAKEAARTQALAHAPQLIALGNLPPDQQAELFAARKRDGSG
>NZ_CP019457.1|WP_033269632.1|3778063_3778621_-|hypothetical-protein
MKHHARTGTGARGGTRKGIRVAVAAGLTLATVATVGGCAFARPRVVVPPSYYPTPTSTSTGYSTDYPTPSYEPTYSPSPTQETYDPDGRADVSGSNCDFSNSLRQFTYTVSITNPSSTDTYSYDMAVNWMKAKPADGKAYGLHERSITVGPGATETYTAKYTVNQSSIGQFWYTCQITRAHKTRM
>NZ_CP019457.1|WP_077192730.1|3778816_3779866_+|hypothetical-protein
MVRNVLGSLIALIGATAAVWSPFRPWYDGRHGRDVRIEDLFNGITRNSAPLFGSLLLPLAFAALVTLVGVALCSRALVALAGLVVLGFTILWMVRQGQAASELTAGARGLGVGVANALGGGALLLLGALIMRGRPRRVRDPEYDRGYDRRYDDARYDERQYDDHGYGRYAPDDRYDERRPPPPAAYPPAAYPPATPEPWDAGRPGAEEWDPEPYAPGPAGPQTGASPYGEQGGSPYREQGDSTPTAPLPVTPPPPQEGQQRPQPLQAPTPQPQQEQRPRAPEPPPTVTSRRPPPTPPVEWGWEHRQAGPPPPPPSPQQQQQQQQQQQAQQEPETPPQPQQPQRAPEERE
>NZ_CP019457.1|WP_077192731.1|3779884_3782488_-|PQQ-binding-like-beta-propeller-repeat-protein
MVEQLKALTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPLPAQAVRWLAAGIAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQARDSRSVTGASDVFSLGSTLVFAATGHAPFHGANPVETVFMLLREGPDLAGLPDELRPLMESCMQMEAGHRPSPADLQSQLAPHLFGSGSDDSGTASAWLPPGAVGLIESRRGGRTAVPRDGAQRAAAGRGAGRPPAPPAVPPMPAPQPVQAPPRPENAPAGDGSGWPGRIGPGAHRGDPRGGHPGPMPQPASLGPDAGAPRATPVSAAPPAVAPDRAAVLSAPSADGAAGPVHLGGSAAPIGPGPRADVRDPQPRGQAAATNWVRPPAGAPTAGVPQQGAAAPLPEAAPAPPAAPPEPPPAEPGRWRPWRFRMSNDVWGTPVVADDLLYVTSFEVHALDVASGRRKFKTRDVAWAMAVADGRIHASDGPSLYALDAEDGTERWRLNTDGWVYALKADRGTVVTSTRGGGVQAWEAATGELLWETVGAQTDFETAEAGPAVHEGTVFVWADARLKALEARTGAERWSYPVGDAAACGGVPMRLLPASDGVVYVVAGTRVLAIDIARGDVRWHFEAPAVFLSPPAFAPGPAVTGGGLYLADYLGTVYALDTADGRDRWRIATEARQSTEPVLVAHGAVHLGSGKALYTLDAVTGTPRWRFQAAAEVVGAPVVAEGRVHFGSADHCLYTLDAMGGQLRWKLATGGEITGSPVAVGGVVYACSKDRCVYALDAAKGTGQARRA

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Crispr_ID: NZ_CP019457_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_6

4407942-4408113

Orphan

Consensus_repeat	Method
CGGCGGCGGTCAGCAGGGCGGCGGC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP019457_6

>merge|NZ_CP019457|6|4407942-4408113|CRISPRCasFinder
CGGTCGCGGTGGCCAGGGCGGCGGCGGCTTCGGCGGCGGTCAGCAGGGCGGCGGCCAGGGTGGCGGCGGCTGGGGCGGCGGCCCCGGCGGCGGCCAGCAGGGCGGCGGCGCTCCCGCCGACGACCCGTGGGCGACCAGCGGTCCTGCCGGTGGCGGTCAGCAGGGTGGCGGC

>NZ_CP019457|6|6|4407942-4408113|CRISPRCasFinder
CGGTCGCGGTGGCCAGGGCGGCGGC	GGCTTCGGCGGCGGTCAGCA
GGGCGGCGGCCAGGGTGGCGGCGGC	TGGGGCGGCGGCCCCGG
CGGCGGCCAGCAGGGCGGCGGCGCT	CCCGCCGACGACCCGTGGGCGACCAGCGGTCCTGC
CGGTGGCGGTCAGCAGGGTGGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_033267023.1\|4409069_4409936_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|226119
NZ_CP019457.1\|WP_006604399.1\|4407206_4407497_+\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NZ_CP019457.1\|WP_033267020.1\|4406659_4406977_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077194801.1\|4417329_4418685_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP019457.1\|WP_033267018.1\|4404298_4405330_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|376473
NZ_CP019457.1\|WP_077192950.1\|4416394_4417120_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP019457.1\|WP_077192945.1\|4409977_4411315_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541
NZ_CP019457.1\|WP_077192947.1\|4413359_4414106_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP019457.1\|WP_077194800.1\|4395704_4395947_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033267019.1\|4405403_4406522_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl\|CDD\|367067
NZ_CP019457.1\|WP_003978893.1\|4408285_4408522_+\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NZ_CP019457.1\|WP_078617102.1\|4400141_4402592_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP019457.1\|WP_033267015.1\|4397736_4398819_-\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491
NZ_CP019457.1\|WP_077192943.1\|4398865_4399543_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP019457.1\|WP_033267014.1\|4396398_4397658_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP019457.1\|WP_033267022.1\|4408540_4408987_+\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NZ_CP019457.1\|WP_077192949.1\|4415146_4416391_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133382
NZ_CP019457.1\|WP_077192946.1\|4411773_4413252_+\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NZ_CP019457.1\|WP_077192944.1\|4402722_4404204_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|227937
NZ_CP019457.1\|WP_077192948.1\|4414220_4415069_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_033267023.1\|4409069_4409936_-\|trypsin-like-serine-protease	gnl\|CDD\|226119	COG3591, COG3591, V8-like Glu-specific endopeptidase [Amino acid transport and metabolism].	2.16684e-08
NZ_CP019457.1\|WP_006604399.1\|4407206_4407497_+\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	6.13058e-40
NZ_CP019457.1\|WP_077194801.1\|4417329_4418685_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.13627e-51
NZ_CP019457.1\|WP_033267018.1\|4404298_4405330_-\|alanine-racemase	gnl\|CDD\|376473	pfam01168, Ala_racemase_N, Alanine racemase, N-terminal domain.	1.88721e-11
NZ_CP019457.1\|WP_077192950.1\|4416394_4417120_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000372314
NZ_CP019457.1\|WP_077192945.1\|4409977_4411315_-\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.38075e-114
NZ_CP019457.1\|WP_077192947.1\|4413359_4414106_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	3.87007e-37
NZ_CP019457.1\|WP_033267019.1\|4405403_4406522_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	2.92611e-35
NZ_CP019457.1\|WP_003978893.1\|4408285_4408522_+\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	5.05083e-38
NZ_CP019457.1\|WP_033267022.1\|4408540_4408987_+\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	1.44346e-64
NZ_CP019457.1\|WP_033267015.1\|4397736_4398819_-\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NZ_CP019457.1\|WP_077192943.1\|4398865_4399543_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.75864e-18
NZ_CP019457.1\|WP_033267014.1\|4396398_4397658_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.89849e-36
NZ_CP019457.1\|WP_078617102.1\|4400141_4402592_+\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	2.63221e-137
NZ_CP019457.1\|WP_077192949.1\|4415146_4416391_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	2.30025e-28
NZ_CP019457.1\|WP_077192946.1\|4411773_4413252_+\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP019457.1\|WP_077192944.1\|4402722_4404204_+\|DUF2029-domain-containing-protein	gnl\|CDD\|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	1.65971e-38
NZ_CP019457.1\|WP_077192948.1\|4414220_4415069_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	4.3144e-43

>NZ_CP019457.1|WP_006604399.1|4407206_4407497_+|30S-ribosomal-protein-S6
MRHYEVMVILDPDLEERAVSPLIENFLSVVREGNGKVEKVDTWGRRRLSYEIKKKPEGIYSVIDLQAEPAVVKELDRQMNLNESVLRTKVLRPETH
>NZ_CP019457.1|WP_033267020.1|4406659_4406977_-|hypothetical-protein
MAQAARTQRSLLSLLNSDGKDHPVENTFALVTVVLGAIAVFTTLSPSLHLVSSWVGLIGIGTGLWGQFISSTTGERFLLIIGLGASALGFYLGLAHGGLFGGVIG
>NZ_CP019457.1|WP_033267019.1|4405403_4406522_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MSLTLRTISREQHLAYIQSLPAASHMQVPAWADVKAEWRAESLGWFDPSGQLVGAGLVLYRQLPKIKRYLAYLPEGPVINWYAPNLEDWLQPMLSHLKQQGAFSVKMGPPVVIRRWDSAAIKSGIQNPDVKRLRDVEATHIEPRAFEVADRLRRMGWQQGEDGGAGFGDVQPRYVFQVPLADRSLEEVHKGFNQLWRRNIKKAEKAGVEVVQGGYDDLAEWQRLYEITAERDRFRPRPLSYFQRMWTALNSEDPNRMRLYFARHDGVNLSAATMLVVGGHVWYSYGASDNIGREVRPSNAMQWRMLQDSYALGASVYDLRGISDSLDENDHLFGLIQFKVGTGGQAAEYLGEWDFPLNKLLHKALDIYMSRR
>NZ_CP019457.1|WP_033267018.1|4404298_4405330_-|alanine-racemase
MALTLYVDTARWRAHQQSVLQQFPGLVPVCKGNGYGFGHERLAEEATRMGADILAVGTTYEAARIKDFFSGDLLVLTPFRHGEEPVPLPDRAIRSVSSVEGVGGLVGARVVIEVMSSMKRHGVKPEDLPKLAAAIEDVRLEGFAMHLPLDRADGSDAVDEVIGWMDQLRNARLPLHTMFVSHLKANELARLQQQFPQTRFRARIGTRLWLGDHEATEYRGSVLDVTRVAKGERFGYRQQKAASDGYLVVVAGGTSHGVGLESPKALHGVMPRAKGVARAGLATVNRNLAPYVWAGKQRWFAEPPHMQVSILFVPGDAPQPQVGEELVAHLRHTTTQFDRLVDR
>NZ_CP019457.1|WP_077192944.1|4402722_4404204_+|DUF2029-domain-containing-protein
MTSARQDEPVRPTKRDEVAAAGSELVGGPIGRRALLGTHWLTPVRIIALVAIGMFALGMVQKLPCYNGGWFFGATSQYTHACYSDIPHLYAGRGFADGLIPYFDRLPGDMEYLEYPVLTGVFMEVASWLTPHGGDLQSREQIYWLVNAGMLMICAAVIAVCVTRTHRRRPWDGLLVALAPAAALTATINWDLLAVALTAAGMLMWSRSRPLAAGVLIGLATAAKLYPVLLLGPLLVLCWRAGAWRAYGKAVAGAVVSWLVVNLPVMITHDATGFHIREGWAKFYTFSQERPIDFGSVWLLISQRTGDPLENANTYATLLMILGCGAIGLLTLYAPRRPRFAQLAFLVVALFILTNKVYSPQYVLWLTPLAVLARPRWRDFLVWQTCEVMYFLGIWMYLAYTGNGDKHQGLPTEGYQLAIALHLLGTLYLCAVVVRDILMPERDVVRRDGDDDPSGGILDRSPDVFVLGRAYHPPRHAVHFEKVPPVRWGAVRE
>NZ_CP019457.1|WP_078617102.1|4400141_4402592_+|penicillin-binding-protein
MGAGGGAGGRGGGGRGGGGRGGGGPEGGRGRGRGSGKPAKRRLIDYPRANRVGWRRFVPSWKQVASLCIGFAGLIVGVSGVALALVNVPNESDAAKSQNNVYLWANGKIMARDGETNRQNVNINEIPKSMQDAAISAENASFRTDSGVDPMGIARAVLNMARGGETQGGSTITQQYVKNAMLSQEQTLDRKFKELFIAIKVGWSKSKNEILQGYLNTSYYGRGAYGIQAAAQAYYGKDAKKLTPDEGAFLATVLKGANLYDPAGGTGPGATKAENTKRAKARWSWILDREVANNLLSKAQRAKYTKFPMPKPPKPVASKSGQIGYLMDTAKKYVLKHAKISEARFDKGGYTIRTTFDEKKTKELTDAVKKVDKRYIDPKKRAKDKYVQFGGASVVPGDGKIVALYGGEGYDKGHFSNNADTFGVPVGSTWKPFVLAAAMKYGTPQTRPQGLSPDSRYNGNPHLKVKDAEGNYVLKRDNSPFYQENESNHRWGYISLYKAMEQSVNTPYVQLGMDVGMDKVRDMAEAAGISEGSFDKNLNPSFALGTSTPSAIRMADAYATFAESGTKVEPYSVTKVTSEGIDLPGFEKPKQETAMDSNIANNVTKVLQNVIQNGTAKEARRLGMPAAGKTGTTDENKSAWFVGYTKQLSTAITMFREDAQNPRQLSMNGVGGFDSIHGGALPTEVWTEYMLQAMNGVSAEQFPAALPIGQKGDEAGMPSPTPTPTPSDTPSQTPSSSPSDSPSPTNSPSPNPTDTCSPWDVNCRNTGGTGNTGGNGNGGGNGGPGGGPGGGTGGTSPTPNPTDANGGGGIFGGPTG
>NZ_CP019457.1|WP_077192943.1|4398865_4399543_-|PadR-family-transcriptional-regulator
MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGTLYPCLKALVANGWLIEETDSAPEGASAAALAGRRAKIVYRLTAAGKEHFEELLAHSGPDAWEDEHFGVRFAFFGQTSRDVRMRVLEGRRSRLEERLEKMRTSLARSRERLDDYTLELQRHGMESVEREVRWLNELIESERAGRDQRAPGPAAQHKNQSGDTGGLPRHRGGSRPDPSDDTTT
>NZ_CP019457.1|WP_033267015.1|4397736_4398819_-|inositol-3-phosphate-synthase
MGSVRVAIVGVGNCAASLVQGVEYYKDADPKSRVPGLMHVQFGDYHVRDVEFVAAFDVDAKKVGLDLADAIGASENNTIKICDVPHAGVQVQRGHTLDGLGKYYRQTIEESAEAPVDIVQVLKDTKADVLVCYLPVGSEDAAKYYAQCAIDAKVGFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVILDRTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSQIRDRELGEDNVHIGPSDFVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDALRAAKIAKDRGIGGPILSASSYFMKSPPVQYFDDEARENVEKFINGEVER
>NZ_CP019457.1|WP_033267014.1|4396398_4397658_-|MFS-transporter
MHAVRDLRVLLRLRDFRSLLAARLLSQAADGVFQVALAAFVVFSPEKQTSPAAIASAMAILLLPYSLLGPFTGVLLDRWRRRQVLLYGNLLRSLLALVTATLIVGKVADWLFYASALAVTAVNRFVLAGLSAALPRVVDGGPRLVMANSLAPTAGTLAATAGGGLAFAVRLAGPHVDTFVVLLAAALYFCSALTALRMTPQLLGPDPAGLQPQLREALLSTVRGLVEGLRHLAERRTPARALTAMTVIRFCYGALTVSVLMLCRYSWADTEAEGLALLGITVLVSGAGFFMAAVVTPWAVARFTAFGWIACCAALGAVLVPALGLFFEPGPMLAAAFVLGLGTQGTKISTDTVVQSSVDDAFRGRIFALYDVLFNVAFVGAAAVAALMLPPDGRSTALLLTVTVLYAAVAAALVRFRRS
>NZ_CP019457.1|WP_077194800.1|4395704_4395947_-|hypothetical-protein
MNDAGNAEAGDCVKKSSSALDDGLEVVDCSGGGAQYKVSKVHDGTSDPSVCSAGEDAYVKTVHRRRRADTAMVLCLTPTK
>NZ_CP019457.1|WP_003978893.1|4408285_4408522_+|30S-ribosomal-protein-S18
MAKPPARKPKKKVCVFCKEKISYVDYKDTNLLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR
>NZ_CP019457.1|WP_033267022.1|4408540_4408987_+|50S-ribosomal-protein-L9
MKIILTHEVSGLGTAGDVVDVKDGYARNYLVPRGFAIRWTKGGEKDVEQIRRGRKIREIATIEQANEVKGQLEGVNVKLAVRAGDAGRLFGSVTPADVAAAIKAAGGPDVDKRRVELGSPIKTLGAHQVSVRLHAEVVAKLGVEVVAA
>NZ_CP019457.1|WP_033267023.1|4409069_4409936_-|trypsin-like-serine-protease
MRSLAWKSVLPLTVVVIMAAAVVGYAAEESDMTGNVASHKSFGKSGESGEDPQDQDPAATAPADDGNAYTPRRTEQNARVGAVFEKDDSGDHFCTASVVQSPGRNMLITAAHCAYDAEAGSTVNDLVFAPDYRDGDEPTGLWKVKKVIIDDRWAKSQDEDLDVAFLILDKKDGKQIQDVLGGNTLGIDRGFDNEVKITGYPTSRDTPISCQNRTTKYSDTQMRIQCTDFEGGTSGSPWLADYDPKSHTGTVIGVLGGHEGGGDQDDVSYAAYFDDDVAVLYRRAQDKD
>NZ_CP019457.1|WP_077192945.1|4409977_4411315_-|MATE-family-efflux-transporter
MTQAPATTRRTDRRHDREIIALALPAFGALVAEPLFVMVDSAVIGHLGTSQLAGLGVAAGLLTTAVSVFVFLAYATTAAVARRVGAGDLPAAIRQGMDGIWLALLLGATVIVAVLPTAPWLVEAFGASATAAPPATTYLRISALGIPAMLVVLAATGVLRGLQDTRTPLYVAIGGFSANAALNVGLVYGAGLGIAGSAWGTVIAQCGMAAVYLAVVIRGARRHGASLRPDAAGIRACAQAGVPLLVRTLSLRAVLLIATAIAARLGDAEVAAHQIVLTLWSLLAFALDAIAIAGQAIIGRYLGAGDADGARAACRRMVQWGIASGVVLGVLVALARPLFIPLFTSDPAVQSPLMTTLLVVALTQPVSGIVFILDGVLMGAGDGPYLAGAMVVTLALFVPAALAVPAFGGGLVALWWAMALMMTVRMLTLWLRTRSGRWIVTGASR
>NZ_CP019457.1|WP_077192946.1|4411773_4413252_+|replicative-DNA-helicase
MSIPEPMEDPWAGSGPSDLLPAARSRRGDGKGRGRGDRPERDDEDGGSWAGGFERVPPQDLDAEQSVLGGMLLSKDAIADVVEVLKGEDFYRPAHELVYQAILDLYAKGEPADPITVAAELTKRGELARVGGASYLHTLVQSVPTAANAEYYAEIVHERAVLRRLVEAGTRITQMGYAADGDVDEIVNKAQAEIYAVTEQRTSEDYLPLGDIMEGALDEIEAIGSRQGQMTGVPTGFTDLDSLTNGLHPGQMIVIAARPAMGKSTLALDFARACSIKSNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGSMTDEDWTRLARRMPDVSAAPLYIDDSPNLSMMEIRAKCRRLKQRNELKLVVIDYLQLMQSGGSKRAESRQQEVSDMSRNLKLLAKELELPVIALSQLNRGPEQRTDKKPMVSDLRESGSIEQDADMVILLHREDAYEKESPRAGEADLIVAKHRNGPTATITVAFQGHYSRFVDMAQT
>NZ_CP019457.1|WP_077192947.1|4413359_4414106_-|dienelactone-hydrolase-family-protein
MTTVTTRTIEYPADGLTMIGHLALPSGTGRRPAVLLGPEGTGLSDVERRRADALAELGYVALAFDLHGGRYLGDPEEMLARCMPLLADPDRMRGIGHAALDVLRAEPRTDPDRIAAIGYGTGGAIGLELGRDGVNLRAIGTVNALTTGRPGEAARIRCPVWAGVGSEDPIMPPAQRDAFAAEMQAAGVDWRLVVYGGALHAFHHPTVDHTVRPGVGYHPRHAQRAWRDVVALLAECLPVTESVRAPSS
>NZ_CP019457.1|WP_077192948.1|4414220_4415069_-|MerR-family-transcriptional-regulator
MTSDAHGQEPIPTVEEAEPAGRDGLTVGRTATLVGVSVKTLHHWDAIGLVYPSERTRAGYRVYSGEDIARIHRVLVYKELGFPLAAIGRILDDPDADARDHLRRQRTQLVERISRLQKMVGSVDRMLEASKTGMRLTPEQQIEIFGDDWQPAWVEEAEKRWGDSAQWAQYAERAAEMTPEDWEGVAAATDALNADLAAAKRAGTAPGSAEANALAERHRASLSTYFDCTHAMQACLARRYVDDPQFAAYYDAIVPGLTAWLRDVVFANAEAHGIDPESARWE
>NZ_CP019457.1|WP_077192949.1|4415146_4416391_+|MerR-family-transcriptional-regulator
MDDSEALLSIGTFARRVGLTPSALRFYDDCGVLRPARVDGVTGYRRYGAGQAARAVRLRQLREAGLPLVDVAVVLDGPEDAAHGVLRAHLERMRRNEAEARALVERLLPEAPEGAGHCRAWARARIGGAELASAVRQVAPAAATGKARERHPVLGHVLLELSAGEARLVATDRYRLAVRVLRPTEFEGGPRCVLIGAEAARGLAEWAVRQRTVELECAGDEAEVRLRSGTDVREVPDGCAAGRGGGAEAAAFPDYRLMLEGLEAGRHRLIVDREALRDAVAGRARVVSLSVSGGGTGGGEDAECGRKERVVSRETASGEAAEVSRETAPGAPAEQTLTVSDGGREPVRLRLIAEGSGLRIAFDPAVLLPALEAGVGPDVLLEITSVERPVVVRSADQGSFTTLVMPVRRSGTED
>NZ_CP019457.1|WP_077192950.1|4416394_4417120_+|hypothetical-protein
MRAEERSVPVDPELPVVRLCVEGMQAEAEGRAATALELFQRAWDTATDDYEACIAAHYLARHQASPEDSLRWNQECLDRADRVGDERVRGFYPSLYVNMGHACRQLGQPALAHAYFVRAADRVSDASEGQYGDWNRFAIAEGLRGTASTVAESGDVARLDVRPRLLDEGVDARLRELFARWCARPDLKALGLTLPAYLGYLGTEEDRMRLRTALHMVHAARWLPENEQAEVEAVIGAVGHG
>NZ_CP019457.1|WP_077194801.1|4417329_4418685_+|serine-hydrolase
MPQTRRALLRRLAGGQAEGRAPSMMGAVVRGGRAVWTGARSSVDGEVPHADVQYRIGSLTKTFVAVLVMRLRDEGLLRLADPVGKHLEDTPVPDATVAQLLAHSAGLTAETAGPWWERTPGTLRPEPADLFGERPQRLPAGRWHHYSNPGYALLGALVERLRGGTPWSEVLRREVLDPLGMGRTTLQPEMPHAGGWAVHPWADVMLPEPAQDTGLMAPAGQLWSTLEDLCRWAAFLLRGDERVLSASSLADMRRPAVPPEETAGQAGYGLGLQLVRHEGRPLFGHSGSMPGFLASLWADAEEDVAGIVLANCTSGPAVSAIAIDLAGIVSEHEPRIPEPWRPQPEPLDPELLALTGPWYWGANPHVLRLRAERALELTPLSGQGRSSRFRAEKDGTWTGLNGYYEGETLRVVRERDGSVSHLDLGTFVFTRGPYEPTAPVPGGVDPGGWRP

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Crispr_ID: NZ_CP019457_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_7

4509366-4509452

Orphan

Consensus_repeat	Method
GCGCTTTTTGCTGACAGTGCTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_7

>merge|NZ_CP019457|7|4509366-4509452|CRISPRCasFinder
GCGCTTTTTGCTGACAGTGCTGACACGTGCTGACAGGCGTCAGCACGGTAAAAGGCCAGGTCAGCGCTTTTTGCTGACATTGCTGAC

>NZ_CP019457|7|7|4509366-4509452|CRISPRCasFinder
GCGCTTTTTGCTGACAGTGCTGAC	ACGTGCTGACAGGCGTCAGCACGGTAAAAGGCCAGGTCA
GCGCTTTTTGCTGACATTGCTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_078617109.1\|4503711_4504386_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP019457.1\|WP_033267091.1\|4505772_4507287_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP019457.1\|WP_051732982.1\|4504439_4505288_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176524
NZ_CP019457.1\|WP_077192992.1\|4511946_4512861_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369034
NZ_CP019457.1\|WP_051732975.1\|4496284_4496929_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NZ_CP019457.1\|WP_077192989.1\|4507565_4508927_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP019457.1\|WP_077192988.1\|4500804_4501515_+\|DNA-primase	unknown	unknown	gnl\|CDD\|214927
NZ_CP019457.1\|WP_077192999.1\|4517275_4517533_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077192996.1\|4514662_4516399_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP019457.1\|WP_033267090.1\|4502556_4503525_-\|topoisomerase-II	unknown	unknown	gnl\|CDD\|376935
NZ_CP019457.1\|WP_033267086.1\|4496936_4498403_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|238520
NZ_CP019457.1\|WP_077192990.1\|4508998_4509190_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225848
NZ_CP019457.1\|WP_033267087.1\|4498564_4500082_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP019457.1\|WP_077192991.1\|4509463_4511461_-\|DUF3987-domain-containing-protein	unknown	unknown	gnl\|CDD\|379041
NZ_CP019457.1\|WP_077192993.1\|4512857_4513364_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077192995.1\|4514082_4514427_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077192994.1\|4513360_4513765_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_159031851.1\|4511667_4511811_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077192997.1\|4516395_4516899_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179385
NZ_CP019457.1\|WP_077192998.1\|4516895_4517279_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_078617109.1\|4503711_4504386_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.53328e-14
NZ_CP019457.1\|WP_033267091.1\|4505772_4507287_+\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.17399e-82
NZ_CP019457.1\|WP_051732982.1\|4504439_4505288_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176524	cd08582, GDPD_like_2, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized bacterial glycerophosphodiester phosphodiesterase and similar proteins. They show high sequence similarity to Escherichia coli glycerophosphodiester phosphodiesterase, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	1.19982e-82
NZ_CP019457.1\|WP_077192992.1\|4511946_4512861_-\|hypothetical-protein	gnl\|CDD\|369034	pfam06679, DUF1180, Protein of unknown function (DUF1180). This family consists of several hypothetical mammalian proteins of around 190 residues in length. The function of this family is unknown.	0.00502794
NZ_CP019457.1\|WP_051732975.1\|4496284_4496929_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.45998e-24
NZ_CP019457.1\|WP_077192989.1\|4507565_4508927_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.52657e-14
NZ_CP019457.1\|WP_077192988.1\|4500804_4501515_+\|DNA-primase	gnl\|CDD\|214927	smart00943, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	3.99622e-16
NZ_CP019457.1\|WP_033267090.1\|4502556_4503525_-\|topoisomerase-II	gnl\|CDD\|376935	pfam02810, SEC-C, SEC-C motif. The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.	1.22017e-07
NZ_CP019457.1\|WP_033267086.1\|4496936_4498403_-\|aminopeptidase-P-family-protein	gnl\|CDD\|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	2.84637e-109
NZ_CP019457.1\|WP_077192990.1\|4508998_4509190_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	4.90284e-06
NZ_CP019457.1\|WP_033267087.1\|4498564_4500082_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	2.98952e-29
NZ_CP019457.1\|WP_077192991.1\|4509463_4511461_-\|DUF3987-domain-containing-protein	gnl\|CDD\|379041	pfam13148, DUF3987, Protein of unknown function (DUF3987). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	2.31426e-105
NZ_CP019457.1\|WP_077192996.1\|4514662_4516399_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	1.26232e-15
NZ_CP019457.1\|WP_077192997.1\|4516395_4516899_-\|hypothetical-protein	gnl\|CDD\|179385	PRK02224, PRK02224, DNA double-strand break repair Rad50 ATPase.	0.00486559

>NZ_CP019457.1|WP_077192990.1|4508998_4509190_-|helix-turn-helix-domain-containing-protein
MSTPKMLKLPEVLAELNMSRAAFYRMRARGQGPRIVKLPNHQIRIRRADLDKWLIGHEEASVA
>NZ_CP019457.1|WP_077192989.1|4507565_4508927_-|tyrosine-type-recombinase/integrase
MLTFDFKIYAIRERANYPKPFQLRWKVGPKPHAQSFVTRTLADGRRAQLMAAAQRGEQFDVQTGLPQSELRAREPQTTWFEHAKDYAEMKWKRSSAKNRATRADALAAVTSALVTDHKSAPEPAILRRALSSRAFNASGRLGDEPEHISVALEWIAKKSLPMPRLEASETIRAALEALSTRLDGKTAAATTITNRRMVFNNALRYAVERRLLPTNPLQFVDWTPPGTDDEIDWRYVPNPQQAKALISAAATLGRRGEHLQAFFGCGYYAATRPAEAMNLRVSDCTLPKTGWGVLLLSGSSPRVGSAWTDDGKPYEERGLKRRARSATRDVPIPPELVRLLRGHLERYGAAPDGRLFQAARGGVLLSKEYPEVWKEARKAALAEEQAMTPLAGVPYSLRHAGVSLWLASGVDPTEVARRAGHSVAVLYRFYAKVLDGKRDQANEQIERALREAE
>NZ_CP019457.1|WP_033267091.1|4505772_4507287_+|PDZ-domain-containing-protein
MSTENEGAAVPSEAEPPTGPKPDSAPASASGAQAPHTPPAPGMPPAAPPPPDFAPSAAAPHGEQAGAMPPAAGYPQQPGHDGTGPVPGTEQTARIPAYAAAGHGSTPGGWGQPPYGGGGNPWAAPNPSAPKRRNGGLIAAVLVAALVAGGVGGGIGFWAAGRDDSASTTVSATGDAGALNRKPTSVSGIAQKALPSVVTIEAQGATGEGGTGTGFIYDKQGHILTNNHVVASAADGGKLTATFSNGKKYDAEVVGHAQGYDVAVIKLKNASGATLNPLPLGKSSNVQVGDATIAIGAPFGLSGTVTTGIISAKDRPVASSDGGGSSASYMSALQTDASINPGNSGGPLMDAGGNVIGINSAIQSAGNGGGMGGESGQSGSIGLGFAIPIDQAKRVAQDLIKTGKPVYPQIGVQVGMRESGDGATIAQTGNNGSEAVTPNGPADKAGLKPGDTITKLDDTVIDSGPTLISEIWQHKPGDEVTLTYKRGGKEHTAKVTLGQRTGDK
>NZ_CP019457.1|WP_051732982.1|4504439_4505288_-|glycerophosphodiester-phosphodiesterase
MTYARPAQDARPGRPAISVVAHRGASEEAPEHTLAAYRRAIEDGADALECDVRLTADGHLVCVHDRRVNRTSNGRGAVSALELADLATLDFGSWKDEAAYGDEAPDRQHEDPERTSVLTLERLLELVADADRRVELAIETKHPTRWAGQVEERLVELLGRFGHTEPARSADRTSPVRVMSFSARSLHRIRTAAPGIPVVYLMQFLSPRYRDGRLPAGVGIAGPGIRILRSHPDYVAKAHRAGHQVHVWTVNDAADVELCQELGVDAVITNRPKQVRMQLGLG
>NZ_CP019457.1|WP_078617109.1|4503711_4504386_-|ATP-binding-protein
MRHCVPLGRFPVQSIGAFIPWRGAKEVSGVALVVAQEVPTSSIMAVPHGPVGVGMARRRMREELFASGVQDSVVDDAVLILSELLSNSCRHARPIYDNESYGSAPAASKDPSCEAGPASVRASWRIDAQGRLTVAVTDGGGPTRPLPATPSVTAHGGRGLAIIRSLAKDWGVRDTVPGEVTVWAVLSLQGAFATRVELTPDLPASLAPGRWPLGTAFADLEDLA
>NZ_CP019457.1|WP_033267090.1|4502556_4503525_-|topoisomerase-II
MAKKRRPQPQSAAPQIKDGEVPVVGAREPCPCGSGRRYKACHGRRAAHAATELVQRPFEGLPGECDWVALRELVPAATAELTLKGGLPEGVPSVTLATVLPMAWPALRRENGAVMLGLQNDTASGDLSRDLADTLQRALATEPGNPVAAARPAADGPRLQDLLDTDAPFEPTVHTGFEFWVENAENATGEVAASLERANAAAVPTARIPGLEGAYWCEAPEKNHLRWVTAHPEEQLLDALARLHAAGTSSLGEDTRLVGSFRAHGLVVPVWDLPSSMGAEDVAKPAAAFAERLAEALAVTTPLTTEERRARGGLTNRQITLS
>NZ_CP019457.1|WP_077192988.1|4500804_4501515_+|DNA-primase
MREILGRRRKLLFRRGGRSALLGAALRCATEWQWPVLPGVGLRTAGRQPAGARLGLGERPAPRCSCPDPDCVVPGAHPFDPGLLAATTDARMVRWWWSNRPDAPIVLATGGRAPCAVSLPAVAGARALAALDHFGVRLGPVVATPTRWSLLVSPYGLPELGELLHSQDWVPSSLRFHGEGGYLVLPPSQIGAGRVRWERPPASGPGAPWLPKVATIVDALVMASTSTPDGGSKLAY
>NZ_CP019457.1|WP_033267087.1|4498564_4500082_-|SpoIIE-family-protein-phosphatase
MAGIEPALPAPAHTAGPHVAQPPADPAADTPSATPADAAPDPACGLPSDAAAVDQLAAVQDRLAGWISDLSTLHDLTEQLIRTRTLQDALHELLRAGALLVGARRGMVVVAPADGLGPETTVGLGLGHAEIGHIETIPRRALSYARILDGLPEPGAAGDDTPDIAEPDIPGEKDLDPRLREVAARLGYAASYAVPLTAAPIGRTGAAVWLYDEPAEPTERQRHLVGLYRAHAAEHLARLLELHRSRQATETLREELLPHRLPRVPGVRLAVRHSTGPRGGGDWYDALPLPDGALGLAVGSVTGSGPSAVAAMGRLRASLRAYAVMEGEDPVAVLSDLELLLRLTEPARSATALFAFTEPPPGAPGGFTGPPGGGWGGAALPRKLVLAGAGHCPPLILGDRRTEFVETSLSAPLGMLACWEAPSVEIEPAGGETLLLYSDGLLHRTGEPMDRAFARLHAAAAGVPRAGRRDPEAVVDHIVRTMLPQGLDDATSEEDVVLLAAYFEE
>NZ_CP019457.1|WP_033267086.1|4496936_4498403_-|aminopeptidase-P-family-protein
MTDELTPETPAEEEQPIKQRKNGLYPGVSDELAANMKSGWADTELRELEPIEQAPNAARRRAALSARFPGERLVIPAGNLKTRSNDTEYSFRASTEYVYLTGDQTDDSVLVLEPRADAADGHEETIYRLPRSNRENGEFWLNGMGELWVGRRHSLAESEALLGVPCKDIRELADVLKEATGPVRVVRGHDAGIETALTDKITAERDEELRVFLSEARAVKDAFEIGELQKAVDSTVRGFEDVVKVLDKAEATSERYIEGTFFLRARVEGNDVGYGSICAAGPHATTLHWVRNNGQVRSGDLLLLDAGVETNTLYTADVTRTLPINGRYSDLQRKIYDAVYEAQEAGIAAVKPGAAFRDFHDASQRVLTEKLVEWGLVEGPVERVLELGLQRRWTLHGTGHMLGLDVHDCAAARTEAYVNGTLEPGMVLTVEPGLYFQADDLTVPEEYRGIGVRIEDDLLVTEDGNRNLSAALPRRSDEVEAWMAGLTK
>NZ_CP019457.1|WP_051732975.1|4496284_4496929_+|TetR/AcrR-family-transcriptional-regulator
MTTAHQAPGETRPGGRTARTRQAVLTAVFAELDDGGFAGLTMEKVAQRSGIHVATLYRRWRCVEGLVCELLTDLSGSVPLPDTGTLPGDLRALAHSITAFYGEGRISRLIEAVVSAAARDPQAASVLRSFFEERLPLAGRMVERAVERGELPPETDPVEVMSALGAPFYYRILIARRPVDAALAESTATAVWAAARAGAYAGTAHGPVDDATGP
>NZ_CP019457.1|WP_077192991.1|4509463_4511461_-|DUF3987-domain-containing-protein
MTQPSPEKHHAGGGFASVHPLREGPHDHAIEAEQAALGAMLLSPAVIPEITAVLDASDYYRPAHETIHRAITTMHERDEPVDPITVTAYLGTTGDLNRVGGAAYLHALVQQVPTASNGEYYAAIARDAADNRRLEATGLRLSQRARAGELTADATRAEALAALEGAEQRTWSEPTPLGENALLPCFPVDALPGWLREQVVALAEFTQTPPDMAATMGLAALSTAAGGRVHVQIRPGWIEQSNLYLVCAMPPASRKSDVFSAMTAPIYRIEDELAQQAKPAIIEAQTAKEAAEAEVDALLAKARKSDTLDRQQLVAEASAARMLADEIRVPPAPRLTVSGDITPEPLTHLLATHRCLAALSPEGDLFDIIAGRYSARPNLGVFLQAHKGERLQTDRITRDQPTVDRPALTIGVTPQPAVLQDLAATPGARDRGLLARFLFALPPSNLGYRKIRTHPIPEAVSSTYDARLEAMVRTFTDLPAPVTVPLSAQADAVVERLQEEVEEKLRPDQPLSHVTDWAGKLVGATVRIACLLHLADRTTTGWGDPVSADCLERAAVIAAYYTAHALAVFDLIAADPATEDARHILTWLQRPKQNGTHRTTVKRRDVVASLRRFRGRTDTIDPALSLLEEHGYLRADRPASPSGRGRAATLTFRVHPAVKDSQDAP
>NZ_CP019457.1|WP_159031851.1|4511667_4511811_-|hypothetical-protein
MALKRGMPTRDPEKARPQDVRDYSQRDGGWTRDPSTRPVPGTPKGAR
>NZ_CP019457.1|WP_077192992.1|4511946_4512861_-|hypothetical-protein
MTATAPENAGTLADRTDELKAKAEQAEAKAKEASAWAVRLMSALGEGTSLLGKSLAARLKGWCLQAHRPDLKGLSADLGIYVRGAVLLGAGAGLCWLVYRHHTLMWPLAAGWSFAALRTKVAAEKAKAKEEVPEGGSESASHRAAGPSSAAFIHLLHDLVDEHSEGAKKTPGLHWPQVAAGLSSRYPGGGSAGGWSAADCRALCEAAAVPVSKGTRARGQGARPGVSTGVRTQDLPERPPLPSPGPSPAAPPGLAVAVVSAGQNEQQASNNNSNTGASNSGEGAARIVQDEHNPARWHVVQQAS
>NZ_CP019457.1|WP_077192993.1|4512857_4513364_-|hypothetical-protein
MNTALTLGGAAVSVAVLIINVRSWWKGNRELKAAIPFGGGLVTGASWTLCLGGLFGWVALQAVEAGNKVGGKAVTGATGATGGGTLAHGSMGALTYPGACAVLIAAVIGGIAWKAAGKTDKKRMLGGVLSGLTLCATAGFAQIMQWVPDLYNALGDGAVSVLNGAVTL
>NZ_CP019457.1|WP_077192994.1|4513360_4513765_-|hypothetical-protein
MPAPFGDQPPIAIRIELVQPEPPKVGFWKRLWRLVTFGLSAYAAWGALAAAVIPIPYVGYGLGRIWGSVLFETGTWTHYAVPNVLGLGVLALTLRGLVGRPTATRFFFFAVASIGATTGVLWPDVVAAMTGVRS
>NZ_CP019457.1|WP_077192995.1|4514082_4514427_-|hypothetical-protein
MTRRSRPGAQVAAGAHSFRIPRQRRGQSTAQPFASPERPHFTGQMDASEEDRAREPLVLTRTILPLHGWWQAVEPAPASLPPGYVTARRPVIAGPDGDELRVRAWLRRRIGGVG
>NZ_CP019457.1|WP_077192996.1|4514662_4516399_-|hypothetical-protein
MIPTLSRLLPDGPSWLSWAAPLATALIAVTVALWGARRLRGSSWLAGIGPQAVVALGGVAVSVYGLWGFATETVHLPRLLAVAFISVFDAAEMTLLVMLYRTADPTVGWTRELHLMHRTAWTLVGFSGAMNAVHAPNWWARPVLAAVPALAAWLIELQLRSKLHAPSRDEDDDVRPGPVRLVALLWQHAWSGLFALLGLDARTSSSAIARAAMAQRAALRVYRLRLALENTPVAGTPRSVRQVQRRRERLRARAQKALDRADVATDPGQSLALVRRLAALTRAEEVALLDYSDAPAVLELIEDLAVTPGAQRIESSVLAEKAEDARQRAEAARREADDARQEAEAARRRAEEALTAAREELTRAEEARDAALADQGGAASAVADARQRAEDARKAEQAARKRAEAILKDAENKAERLRQDAEKALEEAQTATTEQRQHLDALLDQAREAEGLTQQRRTALEEVNRQIQEATLLRDRLRGDLAALSPQAPDGAGSGEGPVWKSPAKERGWQHYLHTLTATDGRAEPTAVELAERFGVDSGNARNWLRDFRAARAAQLAAHPSRAAAHHAVNGTAPAGIA
>NZ_CP019457.1|WP_077192997.1|4516395_4516899_-|hypothetical-protein
MIRIITHARLAALRQDAAQAREQKREVQASADAAYARHVRAVHDLTAEAEAADDKAAEADARAHELRQALDQANIHLAAARASGIERAARIEALSCDLDAMAEAVVLLHYGKLHSVHPNRPAAERHAASVGVGPGSWIPAGKRPVEESAWLISPLSKWAVAVGGDAA
>NZ_CP019457.1|WP_077192998.1|4516895_4517279_-|hypothetical-protein
MIRMDETTTPAAFLQTASEGVRQHNHAASNDGYDSTPEVSRSAVAMVELFARTQQAIDHMGDRVRRDLAAGSLAPDDGTPPEEHACGADLALLDAGIALSALLGYLQEASGHLWHLGMAYEPGEADA
>NZ_CP019457.1|WP_077192999.1|4517275_4517533_-|hypothetical-protein
MSFIVAVQAGVTAVEFDRAPSAAELDAIATETPLIEAEVELLDVRIALLDRLPSELDRRRLRRAQTRVLAERAALANRVTSGEAA

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Crispr_ID: NZ_CP019457_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_8

5247492-5247621

Orphan

Consensus_repeat	Method
GCGGCCTGCTGGGGGTAGCCGTAACCGGGCTGGCCGCCCT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP019457_8

>merge|NZ_CP019457|8|5247492-5247621|PILER-CR
GCCGCCTGCTGCGGGTAGCCGTAACCGGGCTGGCCGCCCTGCGGCGGGACGCCCTGCTGGGGGTAGCCGTACGGCTGCTGGGGGGCCTGCGGGGCCTGCTGGGGGTAGCCGTAGCCGGGCTGGCCGCCCT

>NZ_CP019457|8|1|5247492-5247621|PILER-CR
GCCGCCTGCTGCGGGTAGCCGTAACCGGGCTGGCCGCCCT	GCGGCGGGA
CGCCCTGCTGGGGGTAGCCGTACGGCTGCTGGGGGGCCTG	CGGGGCCTGCTGGGGGTAG
CCGTAGCCGGGCTGGCCGCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_159031864.1\|5240780_5241203_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033271517.1\|5236724_5237903_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP019457.1\|WP_077193287.1\|5244612_5246178_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP019457.1\|WP_033271684.1\|5246256_5246838_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197891
NZ_CP019457.1\|WP_033271680.1\|5249438_5249864_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377188
NZ_CP019457.1\|WP_077193282.1\|5234883_5236197_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|222843
NZ_CP019457.1\|WP_077193290.1\|5255181_5255769_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP019457.1\|WP_033271686.1\|5243980_5244616_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NZ_CP019457.1\|WP_033271678.1\|5253795_5254785_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235468
NZ_CP019457.1\|WP_078617508.1\|5254871_5255057_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_079271681.1\|5242589_5243558_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP019457.1\|WP_077194861.1\|5251073_5251865_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|371292
NZ_CP019457.1\|WP_033271681.1\|5248934_5249363_+\|DUF3017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378602
NZ_CP019457.1\|WP_033271518.1\|5237926_5238811_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP019457.1\|WP_077193289.1\|5252190_5253390_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|371292
NZ_CP019457.1\|WP_077193291.1\|5255827_5256631_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_159031863.1\|5233905_5234790_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077193283.1\|5239044_5239881_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP019457.1\|WP_033271682.1\|5247987_5248842_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|237637
NZ_CP019457.1\|WP_077193288.1\|5250183_5251017_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|366659

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_033271517.1\|5236724_5237903_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP019457.1\|WP_033271678.1\|5253795_5254785_+\|malate-dehydrogenase	gnl\|CDD\|235468	PRK05442, PRK05442, malate dehydrogenase; Provisional.	0
NZ_CP019457.1\|WP_077193287.1\|5244612_5246178_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP019457.1\|WP_033271684.1\|5246256_5246838_-\|hypothetical-protein	gnl\|CDD\|197891	smart00818, Amelogenin, Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth. They seem to regulate formation of crystallites during the secretory stage of tooth enamel development and are thought to play a major role in the structural organisation and mineralisation of developing enamel. The extracellular matrix of the developing enamel comprises two major classes of protein: the hydrophobic amelogenins and the acidic enamelins. Circular dichroism studies of porcine amelogenin have shown that the protein consists of 3 discrete folding units: the N-terminal region appears to contain beta-strand structures, while the C-terminal region displays characteristics of a random coil conformation. Subsequent studies on the bovine protein have indicated the amelogenin structure to contain a repetitive beta-turn segment and a "beta-spiral" between Gln112 and Leu138, which sequester a (Pro, Leu, Gln) rich region. The beta-spiral offers a probable site for interactions with Ca2+ ions. Muatations in the human amelogenin gene (AMGX) cause X-linked hypoplastic amelogenesis imperfecta, a disease characterised by defective enamel. A 9bp deletion in exon 2 of AMGX results in the loss of codons for Ile5, Leu6, Phe7 and Ala8, and replacement by a new threonine codon, disrupting the 16-residue (Met1-Ala16) amelogenin signal peptide.	0.000197659
NZ_CP019457.1\|WP_033271680.1\|5249438_5249864_-\|hypothetical-protein	gnl\|CDD\|377188	pfam03995, Inhibitor_I36, Peptidase inhibitor family I36. This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C and SCO3675 also have probable beta-propellers at their C-termini. This family includes Streptomyces nigrescens SmpI, a known peptidase inhibitor of known structure. This protein has a crystallin like fold pfam00030 and is distantly related by sequence. It is not known whether other members of this family are peptidase inhibitors.	1.68575e-10
NZ_CP019457.1\|WP_077193282.1\|5234883_5236197_+\|hypothetical-protein	gnl\|CDD\|222843	PHA02030, PHA02030, hypothetical protein.	0.000302524
NZ_CP019457.1\|WP_077193290.1\|5255181_5255769_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	5.94873e-15
NZ_CP019457.1\|WP_033271681.1\|5248934_5249363_+\|DUF3017-domain-containing-protein	gnl\|CDD\|378602	pfam11222, DUF3017, Protein of unknown function (DUF3017). This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.	4.31041e-17
NZ_CP019457.1\|WP_079271681.1\|5242589_5243558_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	8.30561e-06
NZ_CP019457.1\|WP_077194861.1\|5251073_5251865_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|371292	pfam10901, DUF2690, Protein of unknown function (DUF2690). This bacterial family of proteins has no known function.	1.08583e-13
NZ_CP019457.1\|WP_033271686.1\|5243980_5244616_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	2.38711e-110
NZ_CP019457.1\|WP_033271518.1\|5237926_5238811_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP019457.1\|WP_077193289.1\|5252190_5253390_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|371292	pfam10901, DUF2690, Protein of unknown function (DUF2690). This bacterial family of proteins has no known function.	1.21866e-14
NZ_CP019457.1\|WP_077193283.1\|5239044_5239881_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	3.96556e-07
NZ_CP019457.1\|WP_033271682.1\|5247987_5248842_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|237637	PRK14193, PRK14193, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional.	0
NZ_CP019457.1\|WP_077193288.1\|5250183_5251017_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	9.56266e-16

>NZ_CP019457.1|WP_033271684.1|5246256_5246838_-|hypothetical-protein
MSYPNQNNPYGPPPGQQPGYGYPQQGVPPQPPQPSPYGPYPGGGPMPGMQPQYPMVMPGGVKAARIMLYVLAGLNLIGLVLAVVGLGGVSRASHDTSPYADSEDLVAMNIGKGLLIAAIVVIVIFTAAAITLAAQFANGGGGVRVGTIIFGVTTTMLSLFSFPLGLVHTILGILVLVFVSKDDGNAWFSRPRY
>NZ_CP019457.1|WP_077193287.1|5244612_5246178_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MTVTEGTQRPIRRALVSVYDKSGLEELAQGLHAAGVQLVSTGSTAAKIAAAGVPVTKVEELTGFPECLDGRVKTLHPKVHAGILADLRLEDHRRQLADLGVEPFDLVIVNLYPFRETVASGATPDECVEQIDIGGPSMVRAAAKNHPSVAVVVNPARYGDVLKAVSDGGFALAERKRLAAEAFQHTAAYDVAVASWFADDYAAVDESGFPDFLGATYTRKNVLRYGENPHQGAALYVSGEGGLAEAEQLHGKEMSYNNYTDTDAARRAAYDHDEPCVAIIKHANPCGIAIGAEVAEAHRKAHACDSLSAFGGVIAVNRPVSVAMAEQVAEIFTEVIVAPGYEDGAVEVLSRKKNIRVLRCPDAPSNPVEVKAVDGGALLQETDRLQAAGDDPANWTLATGAALPAGELAELAFAWRACRAVKSNAILLAKDGATVGVGMGQVNRVDSAKLAVQRAGEDRARGSYAASDAFFPFPDGFEVLAEAGVKAVVQPGGSVRDELVVEAAEKAGVTMYFTGTRHFFH
>NZ_CP019457.1|WP_033271686.1|5243980_5244616_+|phosphoribosylglycinamide-formyltransferase
MPPADPGRPARVVVLVSGSGTNLQALLDAIAGQGAEAYGAEIVAVGADRDGIVGLERAERAGLPTFVCRVKDHASRADWDRALTAATASYEPDLVVSAGFMKILGKEFLARFGDRIVNTHPALLPSFPGAHGVRDALAYGAKVTGCTVHFVDDGVDTGPIIAQSVVEVRDEDDESALHERIKEVERSLLVEVVGRLARHGYRIEGRKVRIS
>NZ_CP019457.1|WP_079271681.1|5242589_5243558_-|hypothetical-protein
MLPPPATAGWYPRPTTSPGAVLLPRERKSSSSKSSSPASAGSDRDNPFAPPPAGTPDQEWQPRHPAPHTHDQDPAQGRGQGHDQGQGQGQGGQGGQGQSPQDEPTRNWGSQWSPRQPGRQSGGFGTRPGGRNGQPNGGPGGPGNLRWDPTDPSQRRARYALLAGMWAFFFVLFSLPEVSLLLGALAIYWGISSLRAKPDPAKATAAATTAAMEGRPTPGTPDDHPAPGATDSRPAPAPGTTSTGPTGPTAPAPGTTRPQVTAAIAGLVTASLALMMVAATFTVQLVYRDYFTCVNDALTQSSSKSCENLLPKELRPLLSVQE
>NZ_CP019457.1|WP_159031864.1|5240780_5241203_-|hypothetical-protein
MQTEREQGEQRTGDEQSEQGHAGGLQCGGGARAAEPGAYPVRQLRRGSPEPGGEQGGAGRPEDVPGRHGEGGEGRARYVQQDAERVGVQVARRGVEQHARRNQQIAGEQGAEEGAGSRLGRGGGVGGPRAETTPWAGVTT
>NZ_CP019457.1|WP_077193283.1|5239044_5239881_-|sigma-70-family-RNA-polymerase-sigma-factor
MTQREQNPAATAFDDLHSRHAAGLTRQAYLLTGRPELARRAVERGFRLAWQRWPQVAVDPDPAGWVRAAVYECALTPWQRLLPWLRTARTAQELPPSVGPADRALLTAVLGLPAPYRRMLVLHDGVGLGLYEAATEVEASTPAAAGRLAHARERVVAEACGPGEVVRVRLAALAASLEVAPSAAPQGAAAQAATPAGATPSALPAAASLLRAESERSACRLTRVTFALTGLFALVTLSVAVVAPDRGAPPWQRPLVTAPAASDAPVQPREARLLPEAR
>NZ_CP019457.1|WP_033271518.1|5237926_5238811_+|succinate--CoA-ligase-subunit-alpha
MAIFLTKESKVIVQGMTGATGMKHTKLMLGDGTNIVGGVNPRKAGTSVDFDGTDVPVFGSVKEAMEKTGADVSVLFVPPAFAKAAVVEAIDAEIPLAVVITEGIAVHDSAAFWAYAKSKGNKTRIIGPNCPGLITPGQSNAGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDIGFSSAVGIGGDPVIGTTHIDALAAFEADPDTDLIVMIGEIGGDAEERAADFIKANVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETARLAREILVG
>NZ_CP019457.1|WP_033271517.1|5236724_5237903_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQARDLFAKHGVPVLAGEVIDTPEAAREATERLGGKSVVKAQVKVGGRGKAGGVKLAGTPDEAVARATDILGMDIKGHTVHKVMIAETAPEILEEYYVSYLLDRTNRTFLAMASVAGGMDIEEVAATTPEKLAKVPVDANEGVSIEKAREIVAQAQFPAEVAEKVAEVMVTLWKTFIAEDALLVEVNPLAKVANGDVIALDGKVSLDANAEFRQPEHEALEDKDAANPLEAAAKAKGLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGENHDNVKPANFLDIGGGASAEVMANGLEIILGDPDVKSVFVNVFGGITACDEVAKGIVQALELLKSKGEDVNKPLVVRLDGNNAELGRQILSDANHPLVQRVDTMDGAADKAAELAAAK
>NZ_CP019457.1|WP_077193282.1|5234883_5236197_+|hypothetical-protein
MRSNIRRSIVVAAAATGLWALGSVAANAAELPVSSDLPSTGTVTGATQQLPTGDVAGTATKTVKKVAGTAQKTVGGVAGKATGALGGVSTQNLPTGKLPQLGDATGAVDGAKKLLGGADLPKTGQVQKAVDPKKAKKVTKAVKKAVKVAKGAGLGKLSDGTVPSVPSLPATPGVPAANLPGGLPTLPKAPALPKAPGSADNLLAGLAGAGIRPEQLTQQAQAALATARPVVDNAAADALPPVARRIVVKVVPVAQGAAGGAGRLAGDAAAQATPFVTVVGGQAQLFVQGAAGDAVPFAQGTATDATAFVQGKATDAVPFAQGKAADAVAFGQGAAADAAPFAKGLATVVVTDGKGTATKAVAGVQSATPVPALPATPAVPSVPSVPSVPSVPAVPAVPAHLTDAVAVPAVPADLAKLTNAANVPALPVLPALPVQGI
>NZ_CP019457.1|WP_159031863.1|5233905_5234790_+|hypothetical-protein
MSAVLALPAAVRLPRTAAARRALLAGLFLVGFVALGFAFGPGAHADDRTGSQALTGATSPARASSEASDPDRAATRDGADDGTDRLAGSGATAAQQGTATRTRLTDGAQSASRELADAVRPAAERTAPVTGRITEPVSRAVRDLGDTAGAVLPVDLPTGGAHTQRPGDGAAHPHGRTPGPAQQAGPRAGTTADGTAARPARCTDRPHTTDAGQSRTTVHEQRDPGHQGLPGQLPQAPSAPASHTAGDGHGPRGGDHQATTPAHSPRFRLLPGGVRTADGAPTRRRAEEILEFPG
>NZ_CP019457.1|WP_033271682.1|5247987_5248842_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase
MTAQILDGKATAAAIKSELTARVEALKAKGVQPGLGTLLVGDDPGSRWYVNGKHRDCAQVGIASIQRELPETATQEEIEAVVRELNEDPACTGYIVQLPLPKGIDANRVLELMDPAKDADGLHPMSLGRLVLGIEGPLPCTPYGIVQLLRRHDVEIKGAHVVVVGRGITIGRPMPLVLTRKSENATVTQCHTGTRDLSAHLKQADIIVAAAGVPHIIKPEDVKPGAAVLDVGVSRDEAGKIVGDVHPGVAEVAGWVAPNPGGVGPMTRAQLLVNVVEAAERAAG
>NZ_CP019457.1|WP_033271681.1|5248934_5249363_+|DUF3017-domain-containing-protein
MAAEAHSDGASEPQRSSRRFPTLTRDTARPEGGGRAASGGFPAPARQWPLLTVMGGVAVGLLLVALDAFRIGALVIGLALLAGAVLRRVLPAVGMLAVRSRFTDMLTYGVLGFVIVMLALMVQPKPWIHIPFLDDIVHFTVR
>NZ_CP019457.1|WP_033271680.1|5249438_5249864_-|hypothetical-protein
MNIRRNVRQRLALTAAAAAVSGGLALAPAAGAFAAPAPAHTQQGSVTLQRAPGNCPRGYLCVYPKPNYKGTPKKVAGNNRDLRRYGGAFNHPWSAFNNGTRCNVTVYERPNYRGGHAKLNRGTGWAYIGGNIMTIYSDKWC
>NZ_CP019457.1|WP_077193288.1|5250183_5251017_+|helix-turn-helix-domain-containing-protein
MSRWKGLPESLDQRVRQLVVQLRRLKDHSGLSLVSLAARTSYSKSSWERYLNGKKLPPRDAVAALARVCDADPTRLLALHEVAAQAWGAAAAPEAGRAADPADPADPPDPGGGADAAVAGEGAPRPAGGPRVRTGSLVVLAALGVVVVAAVALLIVRPWQQDAAGRGTAGTAAGRTAGAVPAFTHRVGETFDCRLTRGPGGLSAGRSRTTTAILGSGATGWDVVEAQCLLHHHGYDPGPVDGIVGENTQRAVKRLQAGAGLPTDGIVGPDTWQVLRR
>NZ_CP019457.1|WP_077194861.1|5251073_5251865_+|XRE-family-transcriptional-regulator
MRELRGRTGLSLAALSARTPYSKSSWERYLNGKKLPPRGAVEALCLLAGEPAGRLVALWELADAAWSRRAAPSVRAEPAAPPGPALPREPSGPAGPPARPPLSRAVAAVAAGACVGVLAVGAALAFWAGEGRGSGPAQRAVPSSSAVTGCRGRACDGKDPQSMFCGGAGLVDTPLERTATRGQHVQVRYGRVCGAAWGRLRNGRVGDRIEVWVPGSAPRSVRVRDRFDAEGYLVTPMAAARGPRGIRLCLYPAGGAAKECFPG
>NZ_CP019457.1|WP_077193289.1|5252190_5253390_+|XRE-family-transcriptional-regulator
MPRWKPLPEELDPQVREFAARLRRLVDRSGLSVSALADRTGFSKTSWERYLNGRLLPPRRAVLALAEATGTHAGHLTTLWELAERAWSRAEMRQDVTMEAIRVAQARAALGEFETPSGQERSSAHATGAVPSGTAGASAGQGNSGASASPNGPAGPSARGVEVAAQRETAAAPWAASVPLQRGAREPAPGDFPGREGEVTRAAPAGAPAAEPGADGADDGDRADRRARGRRAVAWAAGAVGALLVAVAAVLLLHPDAAEGSRTAAAPPAPPASSGARPVLPAGVRCSGADCAGKDPEAMGCGGTRATSASRGTAGGALIEVRYSTVCRAAWARISGAAPGDRATVSADGRRVTARVRRDGAAYTAMVQVTGDPAKVSACGTTAAGANVCARPVTARAAR
>NZ_CP019457.1|WP_033271678.1|5253795_5254785_+|malate-dehydrogenase
MTRTPVNVTVTGAAGQIGYALLFRIASGHLLGADVPVKLRLLEIPQGLKAAEGTAMELEDCAFPLLQGIDISDDPNVAFDGANVALLVGARPRTKGMERGDLLEANGGIFKPQGKAINDHAADDIKVLVVGNPANTNALIAQAAAPDVPRERFTAMTRLDHNRAISQLATKTGAPVSEIKKLTIWGNHSATQYPDIFHATVAGKNAAEIVNDEKWLAENFIPTVAKRGAAIIEARGASSAASAANAAIDHVHTWVNGTADGDWTSMGIPSDGSYGVPEGLISSFPVTTKDGRYEIVQGLEINDFSRERINASVKELEEEREAVRALGLL
>NZ_CP019457.1|WP_078617508.1|5254871_5255057_-|hypothetical-protein
MLVGGPQELPERIVPVDPPGSELKIPFRNGYEHFRATSRQQHTPEGPLPVYEWWERTELPG
>NZ_CP019457.1|WP_077193290.1|5255181_5255769_+|carboxymuconolactone-decarboxylase-family-protein
MARIPLSPPRTVTLRLAEWYSRRAYGKVMQPALVLGHHPKILRAYFAFESRVARWKALDPALRHLAELASAAAIGCSWCVDFGHWQADRLGLPLAKISKVPDWRAHRESFTEPERLVMEYAEAMTATPPAVTDELAADLRGRLGDRAFVELTTMVAVENLRSRLNSAMGLRSQGFSDHCAVPPASAAVPGAAADA
>NZ_CP019457.1|WP_077193291.1|5255827_5256631_-|hypothetical-protein
MTSRCRAVTATAALSCGAALLAGAACTGVAAADDSDGEGDLAGKSAQQISDDALHELVAAHSLRLRTRTSADPTALDLTLDRAGNCTGAISKGPYGRVEIIKHGAQVWMKPDAAFWKSQLPGSKGEEAAAKYRNTFLHGTTRDDFLHSLSEACDLTAFQKSAAAPDEPPSGAPSPSRTPALTKGRPTVHEGARVLPLVKKADGVVQTLYVAIDGKHYPLKLTAEVDHQTGTILLSNYGTPVPATTPAPGDTADISALEDLLQGTQRA

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Crispr_ID: NZ_CP019457_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_9

5588768-5588996

Orphan

Consensus_repeat	Method
CGGTGCCTTCGGCGGTGTCCACGACGGCCTCCGCGGCCTTCGCCGCGGCGGTCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_9

>merge|NZ_CP019457|9|5588768-5588996|CRISPRCasFinder
CCTTGGCCTCGGCGGCGTCCGCGCCGTCCACGGCCGGCTTGGCGGCGGCGGCCTTACGGGTCCGCTTGGGCTTGGCCGGAGCGGCCTCGGTGCCTTCGGCGGTGTCCACGACGGCCTCGGCGGCCTTGGCGGCGGCGGTCTTGCGCGTCCGCTTGGGCTTGGCCGGAGCGGCCTCGGTGCCTTCGGCGGTGTCCACGACGGCCTCCGCGGCCTTCGCCGCGGCGGTCTT

>NZ_CP019457|9|8|5588768-5588996|CRISPRCasFinder
CCTTGGCCTCGGCGGCGTCCGCGCCGTCCACGGCCGGCTTGGCGGCGGCGGCCTT	ACGGGTCCGCTTGGGCTTGGCCGGAGCGGCCTCGGTGCCTTCGGCGGTGTCCACGACGGCCTCGGCGGCCTTGGCGGCGGCGGTCTTGCGCGTCCGCTTGGGCTTGGCCGGAGCGGCCT
CGGTGCCTTCGGCGGTGTCCACGACGGCCTCCGCGGCCTTCGCCGCGGCGGTCTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_077193410.1\|5578908_5579448_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077193417.1\|5597214_5599017_+\|DUF3492-domain-containing-protein	unknown	unknown	gnl\|CDD\|340841
NZ_CP019457.1\|WP_033266080.1\|5581836_5583090_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP019457.1\|WP_033266242.1\|5585095_5585701_+\|MarC-family-protein	unknown	unknown	gnl\|CDD\|225006
NZ_CP019457.1\|WP_077193413.1\|5587734_5588601_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP019457.1\|WP_077193415.1\|5594153_5595164_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP019457.1\|WP_129322867.1\|5599075_5599324_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033266241.1\|5591264_5592002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|205967
NZ_CP019457.1\|WP_033266073.1\|5592048_5592339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033266072.1\|5592610_5592838_-\|DUF3107-domain-containing-protein	unknown	unknown	gnl\|CDD\|378634
NZ_CP019457.1\|WP_033266079.1\|5583343_5583982_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033266077.1\|5586162_5587089_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350289
NZ_CP019457.1\|WP_033266070.1\|5593767_5593983_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077193412.1\|5584149_5585001_+\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_CP019457.1\|WP_077194879.1\|5581212_5581797_+\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP019457.1\|WP_077193416.1\|5595319_5596669_+\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP019457.1\|WP_106974815.1\|5599362_5600733_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_033266076.1\|5587119_5587581_-\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NZ_CP019457.1\|WP_033266071.1\|5592977_5593619_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP019457.1\|WP_077193411.1\|5579559_5580690_-\|magnesium-and-cobalt-transport-protein-CorA	unknown	unknown	gnl\|CDD\|213364

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_033266080.1\|5581836_5583090_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.29419e-92
NZ_CP019457.1\|WP_033266242.1\|5585095_5585701_+\|MarC-family-protein	gnl\|CDD\|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	1.38526e-38
NZ_CP019457.1\|WP_077193413.1\|5587734_5588601_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.31161e-15
NZ_CP019457.1\|WP_077193415.1\|5594153_5595164_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.4161e-28
NZ_CP019457.1\|WP_033266241.1\|5591264_5592002_+\|hypothetical-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	2.40967e-87
NZ_CP019457.1\|WP_033266072.1\|5592610_5592838_-\|DUF3107-domain-containing-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	6.80677e-36
NZ_CP019457.1\|WP_077193417.1\|5597214_5599017_+\|DUF3492-domain-containing-protein	gnl\|CDD\|340841	cd03813, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.	1.15855e-136
NZ_CP019457.1\|WP_033266077.1\|5586162_5587089_+\|NYN-domain-containing-protein	gnl\|CDD\|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.98332e-07
NZ_CP019457.1\|WP_077193416.1\|5595319_5596669_+\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	6.85473e-60
NZ_CP019457.1\|WP_077193412.1\|5584149_5585001_+\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	1.70833e-47
NZ_CP019457.1\|WP_077194879.1\|5581212_5581797_+\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	1.70265e-28
NZ_CP019457.1\|WP_033266076.1\|5587119_5587581_-\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	1.23976e-31
NZ_CP019457.1\|WP_033266071.1\|5592977_5593619_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.13028e-16
NZ_CP019457.1\|WP_077193411.1\|5579559_5580690_-\|magnesium-and-cobalt-transport-protein-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.6102e-172

>NZ_CP019457.1|WP_077193413.1|5587734_5588601_-|alpha/beta-hydrolase
MSRPTVLTLPPCARAYRLDTERGSFAVHDARPEGAPIGTAVLVPGFTGSKEDFIALLEPLAAAGFRAVAVDGRGQHESPGPREEQAYAQRELALDVLAQARAVREADGGPLHLLGHSLGGLVTRAAVLLDAAPFRSLTVLSSGPAAIDAAQQARVRMLIDALGRLDMESVWQAMRELDPPEAADAATPPEIGAFLHRRWLNTVPEQLIATGRQMLEEPDRVAELCRTGLPVHVVSGAVDYAWPVPSMDEMAVRLSARRTVIEGAEHSPNAERPEKTAEALTGFWSGVG
>NZ_CP019457.1|WP_033266076.1|5587119_5587581_-|SRPBCC-domain-containing-protein
MTESSQDDPHGIALNRTFDARRELVFEAWTTPAHFAYWFGGELPVPVERMTMDVRPGGVWSLVMLTPDGGELPFSGIYREVAPPEHLEFTLTDEAAPHGAEGELVRVRLTDLGDRTEMAFRQVGGHLGAEQYQQAEAGWAGFFDRLGELLGRA
>NZ_CP019457.1|WP_033266077.1|5586162_5587089_+|NYN-domain-containing-protein
MNDVQPTGPTDLAALAAGIERTNELLTRVLAEVATSPSTHAAFVDAGYVYAAVGKLVTGTEDRKGFELDAEGLIEAFIDKARTIFADSRLLRVYWYDGARRRIHTQEQQRIAELPDVKVRLGNLNANNQQKGVDSLIRSDLESLARHRAISDAVLIGGDEDLVSAVEAAQGYGARVHLWGIEAPGGRNQAEPLLWEVDSARTFDLAFCKPYVTRRIGAEYADPAAGEGPAPSREEVRFVGARVAAQWLSERGREWVAELLPGHPYLPGTVDQELLTAAEALLRHSLRGHADLRRVLRDGFWEHVQGQY
>NZ_CP019457.1|WP_033266242.1|5585095_5585701_+|MarC-family-protein
MFDVAVFSTLFVTLFVIMDPPGITPIFLALTSGRPAKVQRRMAWQAATVAFCVIAVFGLFGRQILGRLHISTPALMIAGGLLLLLVALDLLTGKSEEPTQTKDVNVALVPLGMPLLAGPGAIVSVILAVQHAHGFAAQVSVWVAIAAIHVVLYLVMRFSLVIIRVIKDGGVVLVTRLAGMMLSALAVQQIINGVLQVIQAA
>NZ_CP019457.1|WP_077193412.1|5584149_5585001_+|PHP-domain-containing-protein
MRIDLHTHSTASDGTDTPAELVRNAAACGLDVVALTDHDTVAGHAEARAALPEGLTLVTGAELSCRLDGVSLHMLAYLFDPEEPELARERELVRDDRVPRARGIVGKLQDLGIPVTWEQVARIAGDGAVGRPHIATALVELGVVGSVNDAFTSLLASDGPAYVEKHELDPFEALRLIKGAGGVAVFAHPLAVKRGRCVPESAIAALATAGLDGIEVDHMDHDAPTRARLRGTAADLGLLTTGSSDYHGSRKTCRLGEYTTDPEIYGEIVRRATGAFPVPGAGG
>NZ_CP019457.1|WP_033266079.1|5583343_5583982_+|hypothetical-protein
MRGEPSCPKCGGRVRAPGLFSDTWQCAVHGTVHPLQPVVPPSVEALGVVVHRAQVPVWMPWPLPVGWLFTGVACAGDDRGGGRATAVACSGPGPLGGPGELLLIAEELGVGLGARYAGIDGLDPGSRMCVDTAPHAKVLAAGRPTPLWHVDGAPSDRAVYAGEARGLWLWAIAWPEKSGVLMYDELVLTDLREAGAEVDLLPCGALSPRILS
>NZ_CP019457.1|WP_033266080.1|5581836_5583090_-|MFS-transporter
MSGTKSGGHADDPFQEGGGSLLRQPKAVWATAGASVVAFMGIGLVDPILPSIARGLHASNSQVSLLFTSYFLITAFAMLVTGFVSSRIGGRKTLLAGLALVVVFAALSGMSGSVGELVGFRAGWGLGNALFVSTSLAVIVGAAAGGSAAAILLYESALGLGMACGPLLGAILGDLKWRYPFFGTAVLMAIGFVAITAFLKEQPRPARKTSLLDPLRALGHGGLASAAVAAFFYNYAFFTVLAFTPFVLDMSPYSSGGVFFAWGVLLAVFSVLVAPRLQHRFGSLKVLGGSLLLLAADLLVLGYGDHTTAVVCTVLSGAFIGLNNTVFTELALGVSDAPRPVASAGYNFVRWFAAAAAPFLAPKIEEWTDLHIPFVVAAAAAVAGAGIVAVRRRALTIEAAEPAPRHAAQDGVSAFAN
>NZ_CP019457.1|WP_077194879.1|5581212_5581797_+|suppressor-of-fused-domain-protein
MSDVLELVEARLRMSLGEPDARAAVTFLGTDRIEVLRFVDGDVVRYATLGMSAQPMSDPTAVLADPLRGPRAELVLSVRAGRAETDKVLRPLAVLAASPQVEGVVVAPGASLDVGEPLWPGAAFSSVLVAEPGGLVEDLALDEPREPVRFLPLLPMTPNEAAWKRVHGAEALQDRWLRHGTDLRDPLRSGVPLD
>NZ_CP019457.1|WP_077193411.1|5579559_5580690_-|magnesium-and-cobalt-transport-protein-CorA
MSMIRDLRAAVRPSRRRDDTPYRYENTPACPNSAIVDCGVYREGRRVSDHVSPAEAMAGVRSEGGFAWIGLHEPTEAEFAGIAKEFGLHPLAVEDAVHAHQRPKLERYDETLFTVFKTVHYVEHTELTATSEVVETGEVMCFTGRDFIVTVRHGGQGSLRALRHRLQDDPELLAKGPSAVLHAIADQVVDGYMAVANAVQDDIDEVEIDVFSSGTNGKGNGNGTKGSAKGGDAGRIYQLKREVLEFKRAVSPLLRPMQLLSERPMRLVDSDIQKYFRDVADHLARVNEQVLSFDDLLNSILQANLSQAAVAQNEDMRKITAWAAIFAVPTMIAGIYGMNFTYMPELHWKYGYPAMMLVTVAICVGIHRGFKRNGWL
>NZ_CP019457.1|WP_077193410.1|5578908_5579448_-|hypothetical-protein
MTETVSQALQDRALIEEATKKSGLIWVRGTTGPARALWHLWHDGAACLVGGPGEQPLDDLGLTDGGTATVTVRSKDKGGRLVAWEARVVEPAPGSEAWQAAVEELKGKRLNAPDADTLTERWARECRVLRLEPTGAEATQRPGRMPEVSHAAPPPASPAITRRPAPAALPKLLRRGRKG
>NZ_CP019457.1|WP_033266241.1|5591264_5592002_+|hypothetical-protein
MGTPDNAAADAQEHTGIAAQDWAQASADPQYRAAVIDLLGALAYGELSAFERLAEDAKLAPTMDDKAELAKMASAEFHHFERLRERLAQIEAEPNEAMEPFAAALDEFHRQTAPSDWLEGLVKAYVGDSIASDFYREVAARLDSETRDLVLAVLDDTGHASFAVEKVRAAIEAEPRVGGRLALWARRLMGEALSQAQRVVADRDALSTMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLAA
>NZ_CP019457.1|WP_033266073.1|5592048_5592339_-|hypothetical-protein
MILEALGAVLIGLAIALFAMRRLPDRFPARTLTLATGPVAALLGALLTRSILGPGHPVQVMVAAVAVGAALLSVLVRPPRSRLRRPAAPLKGHRTA
>NZ_CP019457.1|WP_033266072.1|5592610_5592838_-|DUF3107-domain-containing-protein
MEVKIGVQHAPREIVLESGQSAEEVERAVSEALAGKSELLKLVDEHGRKVLVPADRLAYVELGEPAGRRVGFGAL
>NZ_CP019457.1|WP_033266071.1|5592977_5593619_-|TetR/AcrR-family-transcriptional-regulator
MSAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKLDLYLALLDQHCEALLHSVRSALASTNDNKQRVAATMDAYFAYVEDPGGAFRLVFESDLTNEPAVRERVDKVSLECAEAISAVIAEDTGLSQDESMLLAVGLGGVSQVVARYWLSSGSQVPRDTAVALLTSLTWKGIAGFPLHGSDTH
>NZ_CP019457.1|WP_033266070.1|5593767_5593983_-|hypothetical-protein
MPVDPTDPDTFEDETDATELDVEAPEADAAEQYTDIAPQRDEPLTEVTPEANEADLVEQARVVQINEDEYR
>NZ_CP019457.1|WP_077193415.1|5594153_5595164_+|alpha/beta-hydrolase
MSSTESPDTAAAALPVPPAGPGGRAAAETVRTVTLPGLTLSVRAPLERDGRPAGGDGAERAPALYLHGLGGSSQNWSALMPLLADRLDGEALDLPGFGHSPPPDDGSYSVSAQARAVIRYLDAAGRGPVHLLGNSMGGAAATRVAAVRPDLVRTLTLISPALPELRPQRTAVPTALLAVPGLAGLFGRLTRDWTPERRTREVLALCYGDLGRVTPEGFNAAADEYRRRLELPYFWEVMERSARGLVNAYTLGGQHNLWRQAERVLAPTLLVYGGRDRLVSFRMARRAAAAFRGSRLLTLPEAGHVAMMEYPEAVARAVRELLDSEVNDVTADAGRS
>NZ_CP019457.1|WP_077193416.1|5595319_5596669_+|DUF3152-domain-containing-protein
MRGGHPEQHEPGGGWGTFPGAPEAPVTPGGGAGPRIPRPRAEMSGGRPLAAPGSGPGPRREYVDAFDAGVYPAGPGRSAAADGPADPEDDVFRAGAPDASARRAAPVVPPGARFTGRSVVFAREGTGSGPDGPDGPGAHPGSGAAGAGNAQPGVTVDQDPAGQDPADAVGADPDEARHGARKGSMGRTFTGAAAAAVTTVLAVVIAGQVAEQHKDGGDPQPRSGNDRTDGAGDETSRSNARPTQDAKAAGYDEQMTQVFPLAADLTATGRFKPVGSDAKAPGHGKLLRYRVDIEEGLPLDGKLFAEAVHKTLNDDRSWAHGGQRTFQRVASGPADFVITLASPGTTAKWCAKSGLDTTEDNVSCDSAATDRVMINAYRWAQGAKTYGRDKMLAYRQMLINHEVGHRLGHNHEICSRQGALAPVMMQQTKFLTTDGVTCRPNSWPFPTQR
>NZ_CP019457.1|WP_077193417.1|5597214_5599017_+|DUF3492-domain-containing-protein
MRIGLLTEGGYPYASGESHAWCDRLVRGLTGHDFEVYALSGRPCRDARGGHRLPEHVRRVHGAPLWGDFPAAHLRAAEERRGRTPGRRARRRFTEHFGALVSAFAAAPAGGRPGDREEPPDNAPTSKADRFASGLYGLAELAREHGGLPALLHSEDAVRTLEAVCHGPRALSAAHGAQVNDLLAVAEQLELALRPLSLDWYGDGSAPGLDAVDLCHATSGGAAALPGLLAKRFFGTPLLVTEYGVRLREHYLARAAAPISAPVRALLAAFQGALAAETYAQAALITPGNIHARRWQERCGADRARLRTVYPGMDAAPFAAVADAPADDSRTLVWVGAIEPAKDLVALLHAFAELRRTEPAVTLRIVGGLGRDPQAPGYLAHCRALAAQLFPDEAADARTVGENPVSFEEIGGPDVPALADAYASATVVVLSSVVEGFPRSLVEAMFCGRATVSTDAGAVCEVIGGTGLVVPPRNPRALAEACRALLGDPDRRARLGAAARARALELFTVEQNIAAFRGIYLELMSHAPARPAGRRGRHAEGLPRPFDRPAESHVPGRWAATGAAHRCGAVTGPGAPAGRTPSWAAPEQERGAGARVMSEP
>NZ_CP019457.1|WP_129322867.1|5599075_5599324_+|hypothetical-protein
MAVMTGVLDVMCAMGVVGVALVTGMADVAHAGNRDGLRRRGRPGAPATAAAHPVPALLRTLAGPLRPGRAACPPAPGKRDGV
>NZ_CP019457.1|WP_106974815.1|5599362_5600733_+|hypothetical-protein
MGEGRDGTGTERDAGLESPAGRPARRGSADPVRALMHRHHTLCAHAVDALEIAAGLEAHGVTDRTAARFRHRDVFSLAEELYARVPRADQNGTAGAPAGGGSAGAPGGGSAAVHGTGPAGGPGAGEGYPEACIPAAGAARAGSPGTGGGWGGRCAAVLQLLPGAVTTATVAALAALTSPPGAATPALPAVPATPAVRTAVGAVGVVLVVLAVRLAVRSGPLRARHHGTGARTTGLWVCWTAGYAVYGDWLLGQLLAGGPDLPSATPRADVATAVALSLAVLPAAGCARWFALRGRRALAASRGLEEFAALVRPLLLGATLLFLGALTALLLGARAALGSHGAPAPAVVAPAALGVLLFLARLLAVHGFPRAAVTGLACAAALEALAPALVLIARLPGLTPLGLPVETLTTAAGPAAVPAVAAGVAALGLLGYGLRALTGACAHSPAPTGPAGTPRP

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Crispr_ID: NZ_CP019457_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019457_10

6413425-6413495

Orphan

Consensus_repeat	Method
CACGGCCACGGGAGCGCCGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019457_10

>merge|NZ_CP019457|10|6413425-6413495|CRISPRCasFinder
CACGGCCACGGGAGCGCCGGAGCAGCCCACCGTGGAAGGCGTCACCGCCGCGGCCACGGGAGCGCCGGAGC

>NZ_CP019457|10|9|6413425-6413495|CRISPRCasFinder
CACGGCCACGGGAGCGCCGGAGC	AGCCCACCGTGGAAGGCGTCACCGC
CGCGGCCACGGGAGCGCCGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019457.1\|WP_077193693.1\|6415245_6415611_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_077193703.1\|6443567_6445523_+\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_CP019457.1\|WP_077193691.1\|6414699_6415122_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NZ_CP019457.1\|WP_077193680.1\|6400598_6401996_+\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NZ_CP019457.1\|WP_077193684.1\|6403333_6406078_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP019457.1\|WP_077193676.1\|6389897_6394577_-\|BREX-system-serine/threonine-kinase-PglW	unknown	unknown	gnl\|CDD\|380284
NZ_CP019457.1\|WP_077193678.1\|6395778_6396411_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP019457.1\|WP_077193699.1\|6437979_6440820_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379062
NZ_CP019457.1\|WP_077193689.1\|6410336_6410849_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236382
NZ_CP019457.1\|WP_077193701.1\|6441423_6441858_+\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP019457.1\|WP_077193682.1\|6402006_6403332_+\|type-VII-secretion-protein-EccB	unknown	unknown	gnl\|CDD\|368288
NZ_CP019457.1\|WP_077193698.1\|6437427_6437853_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019457.1\|WP_159031870.1\|6406074_6409332_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|163057
NZ_CP019457.1\|WP_077193696.1\|6432905_6433955_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NZ_CP019457.1\|WP_077193695.1\|6415621_6432538_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP019457.1\|WP_077193702.1\|6441854_6443486_+\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_CP019457.1\|WP_077193679.1\|6396550_6400531_+\|type-VII-secretion-protein-EccCa	unknown	unknown	gnl\|CDD\|274858
NZ_CP019457.1\|WP_077193686.1\|6409542_6409836_+\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NZ_CP019457.1\|WP_077193687.1\|6409864_6410155_+\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP019457.1\|WP_077193697.1\|6434236_6437137_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938

Protein	Function_ID	Function_description	E-value
NZ_CP019457.1\|WP_077193703.1\|6443567_6445523_+\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_CP019457.1\|WP_077193691.1\|6414699_6415122_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	7.63816e-09
NZ_CP019457.1\|WP_077193680.1\|6400598_6401996_+\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	1.33268e-33
NZ_CP019457.1\|WP_077193684.1\|6403333_6406078_+\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	3.92286e-14
NZ_CP019457.1\|WP_077193676.1\|6389897_6394577_-\|BREX-system-serine/threonine-kinase-PglW	gnl\|CDD\|380284	NF033442, BREX_PglW, BREX system serine/threonine kinase PglW. Members of this family are PglW, a predicted serine/threonine kinase of the Pgl (phage growth limitation) system (now called BREX type 2) and the BREX type 3 system.	0
NZ_CP019457.1\|WP_077193678.1\|6395778_6396411_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.20029e-19
NZ_CP019457.1\|WP_077193699.1\|6437979_6440820_-\|AAA-family-ATPase	gnl\|CDD\|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	4.94601e-15
NZ_CP019457.1\|WP_077193689.1\|6410336_6410849_+\|hypothetical-protein	gnl\|CDD\|236382	PRK09111, PRK09111, DNA polymerase III subunits gamma and tau; Validated.	0.000424616
NZ_CP019457.1\|WP_077193701.1\|6441423_6441858_+\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	1.52032e-28
NZ_CP019457.1\|WP_077193682.1\|6402006_6403332_+\|type-VII-secretion-protein-EccB	gnl\|CDD\|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	6.02584e-69
NZ_CP019457.1\|WP_159031870.1\|6406074_6409332_+\|AAA-family-ATPase	gnl\|CDD\|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	1.55444e-77
NZ_CP019457.1\|WP_077193696.1\|6432905_6433955_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	3.38037e-70
NZ_CP019457.1\|WP_077193695.1\|6415621_6432538_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.23081e-15
NZ_CP019457.1\|WP_077193702.1\|6441854_6443486_+\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	4.9883e-180
NZ_CP019457.1\|WP_077193679.1\|6396550_6400531_+\|type-VII-secretion-protein-EccCa	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP019457.1\|WP_077193686.1\|6409542_6409836_+\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	2.1e-07
NZ_CP019457.1\|WP_077193687.1\|6409864_6410155_+\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	3.324e-06
NZ_CP019457.1\|WP_077193697.1\|6434236_6437137_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	2.52658e-36

>NZ_CP019457.1|WP_077193689.1|6410336_6410849_+|hypothetical-protein
MGSTSVDTPSLDVVARNIESLKEPVKDAMDRLRQVKLAPGSFYDADQLKTKTVGANADGGLKDQMVKALSDLYNGLTDVSDAMRTLSRNYSTAEEANGIKAVDLRNSIERAQADFGAMLKDTGGAPAAPGGGGGSPPSTGGSAPSAGGSAPSPAASGPSTAGSAPSTSAA
>NZ_CP019457.1|WP_077193687.1|6409864_6410155_+|WXG100-family-type-VII-secretion-target
MPTYTVNFAQVDHVTEEMTTISRNISNMLSSLDASARQHLAEWTSAAQTAYAENKAKWDTAAADMVQQATNAGNALQEIRASYSQAEGTNSSMWSR
>NZ_CP019457.1|WP_077193686.1|6409542_6409836_+|WXG100-family-type-VII-secretion-target
MNAALGAFREADSTARAQLSAMQEQVSVLTSNWTGDAAARFGGAMHTWLEDFQTVVTALDRMVSTLEQNTGVYRSTHDSTEQAASNLASRMHAPLSL
>NZ_CP019457.1|WP_159031870.1|6406074_6409332_+|AAA-family-ATPase
MTRQVLLVSAQRPGAHRSIAEALSQAGEGALVSVEAGRYEERILLTGAVTLAAQDGQGSVEIHASTGSVLVVDSDEVRLSGLVLSGADEQYPAVDLRRGQAAFDGCSISGRAWTAVLARDQGTLVARDSTVDNPRGAGIVVTSPGANTVENCRVAEAGSSAVVVAAQGRLTVRGCTLTGSGGNAVCVNGQGQATVEDTTVADSRKPALVVEEEGSAEVRRVVVTGSAGPDAYLTSSAPVTLTDCTFSGAEGESVHIAAGSAPLLRGCTVTGAGRCGVRITGAATPRLEACEIRDAPLGLVVDANSAPTASRLAVHDARQVAVLVTEGSAAEFGGLTVVGDAGGVRVLGGARLQLRGAEVELTSGDAVVVGEGATGRFGELTVRTARGAGLKVTGAADVVAESSQLHGGGVVVDTDAAVRLDDTVVAASDTDGIRVLNGGSLVAERCRVHGARGHGVRLDATGRGDLRSCTVEGNEGEGIRSDSVEPVRMHDCEVRDNGGPRPTPTRGGRPDPANRAGAPPEERDGPGRPDRGTRPEPSGQAGNGPLAELEALVGLESVKQEVTGLINLNRMAQRREEMGLPMPPMSRHLVFAGPPGTGKTTVARLYGAVLAELGILGEGHLVEVSRADLVAQIIGGTAIKTTEVCTRALGGVLFIDEAYTLTNQGKGIGPDFGQEAVETLMKLMEDHRDELVVIVAGYSEQMEQFLSSNPGMASRFSRTVEFPNYSPVELVTITRNMCGRHYYELDDSAHEALVRYFEQIPKGATFGNGRVARSVFESMVSYQASRLAMVPGTGDAELSRLTAADVPELPGGDDPDRRPPGPEGARGRGSARLSALVGLAEVRQALAARLSGLGQLRAGQQPVALTANLVFEGRPGGGRRSVARLYARALAEQGVLAAGVLHRVPLSVFPARWHGQAETFTSDAFDEAAGGVLLLEADRPFADRPDEERSAVLDAVQRAAHAGSEVAVVLSGEAPQLAEVLRESPNLAGCFAEYLRFALYGPEELAELVLRRLARHGRAVDDGLRQALGVHFADTAHPEGAYGAHRFADRLAAAAPTRTIRVADLPDGAGAAAAGPAVASTTARA
>NZ_CP019457.1|WP_077193684.1|6403333_6406078_+|hypothetical-protein
MRIPVGNLRPTAPAVECLTVGHAVLVRPKGTDERGGRRSRSWAEGLALDPDHRLVVVDVPAAFPLTAWRPVAGRLGRDDGVSRGLRLVPVPGSAGELMPAGQWLADRLGTDVLVPVGEVVRVDDGSLFVRGDAESGWLRLRPDAAPHWDSRRAPKPEWEDWMVNQSWNPGPLGVCEPLPGGAWLRPASDDLWHRVHRLRLTSVVPCHRTQLCVVLGHPDGSPLPLADVARFWHAVPEEHRGEVRFVGYGPVAAPAEETLGQALSDLLGRPVTVYCGLPVAGPAVTGLPDVHTVCPDGSSGWRPFARELGYLPRQQSGGQVMPPRPVSHRPPVHGLPELSPGVYGFAPDAVLEVTQSGLWMRPPTEPADAHAVRALPLDPTAAKILYDTSSQQSAERMQLLALGALWRLDPATRQSSQVLPAAMATSGAGAPGGQVTSGGQEVSGGQKAPAGVAPDGLAPAGSVPAPEAATVQPGVAADTTEPEPASDPATVTPEPATAMAPAAAVPPEPLPAPPPAVRLEADLLPPPPPPAAEAASAVPVSAAPASVPAFAGAAPRPPGGAEPVPDLPEAPASGEPAPEGAPQQSESKQASKQPGPTASDDGAAPVGAPVGAGRPTVPEPSDDDPRVQPTPRPEACAVPPSGGIDRERDWLRGALRQQYDAAASSLARLLSQSPGLRGDARKPSEDTLTDLVAVRLYLSAEGSEIDAAVRGATVGPHVPLARCVYEGLRRLPSHRGAGVLRTTVSDAQWQWYRQQRLVTEWGFCPALTSAPGELPGTVDFLIWSLTARRTVLLEPAVADRVVFLPGTSFKVLDVRQEDRRAVLLRELSPSEIGPDGTVDLASGRLDEAAVAGLERAAENWRGANPPEPLPEHGWDSFGSPPGLIGPPRIAKQGTVHGSTQGTTRENSQVKGSPS
>NZ_CP019457.1|WP_077193682.1|6402006_6403332_+|type-VII-secretion-protein-EccB
MQSRRDHVQAYRFSIGRLISAVVTGDPGNGESPTRRADLGAVIGLAVAALLIGGAAVYGLISPGADKSWRKPGSLIVEKETGTRYLFLDGVLRPTRNYASALLVAGANPTVRSISRDALREVRRGAPIGIPDAPDSVPAPAELLHGAWNVCLDGRDKEAVQIDFAPGPDTELGDDRRILLADPDGAKYVLWKDSKYPVRDFSALVALGLGDHEPMEAPTAWLSDLPTGTALAPADIPGAGKPGPRVGGRPAKVGQLFRTGQAGASQYLVLRSDGLAPLTRTEAALLQARPGHPAPVEVATADVAAARGSDDRTLLGRLPDLLSVAEWRGDRDRLCVRQRASGTKVKATVVVRDGAVSSGAGVRVPPGRGMYAAELAPRKGEQAPRRYLITDQRRKYPLTDDATAYALGYGRVAPLPVPRKVLDAVPSGPALAAAGRGRGGR
>NZ_CP019457.1|WP_077193680.1|6400598_6401996_+|type-VII-secretion-integral-membrane-protein-EccD
MTTASSTAVAGRSDVCRLTVVGPERRADLAVPATVTVGDLLGVVRGHVCGTPVRSEGEWVLQRLGEPPLDPDGTPATLDLRDGEVLHLRPVDDALAVLHFDDVAEGVAEMVGTPAVRWRPELTRRLLLGLACLVLGVLAAGVWQVGPGRGMAVAAAAIAVALGAACVVATRLRPDRAIGMITGLVGCLFAGLAGATAARGAAGVLAPGRGDVALAGVCVAVAAAGALALRRAPAEVFGSVLATSAAALTGLGISTVLGLDATRSMGVLAVGAFVTATLGMRIAVRVARLRVPQLPRTAAELQEGIEPEPATRVARRTRIADVCLTSLAVSGAAVFALALWLLSREPGWIGPVLATVLGGAVLLRTRVLVGPWQRIPMAVGGALGPLLVLLSLLESAPPLVGAVLLLVLLAAAGLLLVAARRMPGSRPLPVWGHAGDLLETWTAVALIPLLLQLVHVYAAIRSLVG
>NZ_CP019457.1|WP_077193679.1|6396550_6400531_+|type-VII-secretion-protein-EccCa
MSTVIVKRSPRADGPPMPAGRVELAEPPVLGEPATADLGSVLLYLPMGLGTTAMVLMFSTGGSSPTSYLMSGVMGIAMVSMTFSQLGRGGAERKRRIRAERRDYLRYLAQLRAQARAAAEEQRAAVCWDNPRPQHLAALAAGPRLWERRPGHQDFAQVRTGVGTRRAALEFVPPHTRPVEDLEPLSAVSLRRFARASRAVPGVPVTVALRRFTSVELVGDREGVLGLARAVVGQLATFHSPDELRIALLTDDAGRAEWDWVKWLPHHAHPEREDATGPLRLAAQDHDVLMELLGAEFADRPDHDQSAVPGTTEPFVVIVADGVDLPERCRLLDGGVRCAVVLDVTGSLRGGPKVLRLPVENGTVTFPTGETTADAEADLLTEAGAERLARTLAPRRTSGTVDLLDKPLETDFDLTTLLGIRDARGFDVASLWRPRTEQQARLVVPIGVTEDGEVVEVDLKESAQGGMGPHGLLIGATGSGKSELLRTLVVGLAATHSSDVLNLVLVDFKGGATFLNMDRLPHTSAVITNLSDELPLVDRMQDSLTGEVIRRQELLRESGYSSLFDYEKARLAGARLAPLPSLVIVVDEFSELLASKPDFAELFVMIGRVGRSLGIHLLLASQRLDEGRINRVEGHLSYRIALRTFSSMESRSVIGSSSAYELPSEPGHGYLKIDTTNLVRFKAAYVSGPCPEPPMASTPGARAARVACEVVPFRLEPAPAAAPEPEPTHHVPPSPTAAGADAEQESGPTGRGDSLLEVMVDRLVDAGPPARQVWLPPLDESPSLDHLLPGIVPDPVRGMAAGESARHGALRVPLGVVDRPYEQLRELLEADLSGADGHVAVAGAPQMGKSTLLRSLMLSLALTHTPAEVQFYCLDLGGGLASVSGLPHVGSVAGRLDRDRVLRTVEEISQLLEVRERQFADLSLENMAGYRESRARGELDSPYGDVFLVVDGWATLRQDFEDLETRIAELAARGLAFGVHVVISAVRWSEIRPRLRDLIGTRLELRLGDAMESEVGTRAAGDVPQQSGRGLTGSGYHFRAALPRLDGSSEPAELATATRAAVAEVAAFWTGAAVPGVRLLPTHLAVERLPAPEDGPRVCVGWDEQRLQPVWHDFSHTPHLMVFGDGETGKSNALRLMARALTSHFSPERARILLADPGRELLKDVPEAYRVGYVVDTEALADVAGSAAVSMQKRLPGPEITPERLHQRDWWEGPELFLLIDDYDLLATGGAVGGPLAPLVPYLAQGVHIGLHLVVSRSTSGAMRAMMDPLLRRMWELGSPALLLSYPNEEGKFLGEAKPRTLPPGRAQLVTRRGVKLVQTGLASPR
>NZ_CP019457.1|WP_077193678.1|6395778_6396411_+|response-regulator-transcription-factor
MESVSFTILAADPLSGAGAAALLRPYPTVSLLAAECGAEADVLLVLAGEVTTETLDSIERAVRDAANPRMRVVLVGDMVRKQHLLRAVNCGLISLIPRREASTERLLRAVIGARDGRAELPTQGAAWLLDWARTVQSDVLTPIGLTTNGLVTREVEVIKLLADGLETAAIAQRLNYSERTIKNIIYGAMSRLQLRNRAHAVAYAFRTGVI
>NZ_CP019457.1|WP_077193676.1|6389897_6394577_-|BREX-system-serine/threonine-kinase-PglW
MREGRWTTVTESEFDHERRGLTAIREKLPDADPWRAWSNFVFTANSGHVREVDLLVVAPGGVCLIELKNWHGSLASENGTWVQTTSRGRRITHGNPLHLVNKKAKELAGRLGQHGKRVWVAEAVCFTEGSLRIRLPAHDQNGVYTVDELVAMLKQPPRDERHRITATGSREVKAALDRVGIRKSDAEYKVGPYELKRKSFDSGPTWADYLAEHSELPESARVRIYLRERGSDATIRQSVENAARREAAVLQRFSHVGAVQLKQYNPSGHTAGPALIFDYHPQTLRLDEYLLQYGAKLDILGRMALVRQLAETMRSAHSSRIYHRALAARSVHVIPRDRGRRGQVIGEEAAWLTPHLQVSDWQIATQRSGSGGSGPGPARLAPTALSTTHLAEGSDAYLAPELRALNADPVYLDVYGLGVLTYLLVTGKPPAASQAELLARLEAEEGLRPSSLVDGLAEDIDQLVQLATAYRPEHRLSTVDEFLEMLELVEDALTAPAAAPAPAAPEKDPLEAVAGDVLDGRWEVRRRLGTGSTSRAFLVRDLEAEARRTRPLAVLKVALSDSRGEVLAREAEVMGRLRPDSRVIRLVEPQPLRIAGRTLLALEYVGDEREETGDGVESSSGRTRRRGETVARQLREGGRLQIDQLEAYGDYLFGAVDFLEGESVWHRDIKPDNIAIRVRPNRTRELVLIDFSLAGYPAREYEAGTDGYLDPFIGTLTRTAYDSHAERYAVAVTLHQMASGELPKWGDGSVLPRQTDQKEFPYPTIAADAFEPAVRDGLVDFFRKALHRDAARRYPELKPMRDAWKKIFLDASQAVPSSRSRQPEAPAPTADGGRPAIADAEPLTAEQQRDQLAKDVTRETHLSAAGLTPAAESFLYGLDITTVGGLLDYSRRKLVNAPGLGAKTRGEVQRRQREWGELLREAPVSPLTPRGRAEAKEELAQLTASESTVLDSLAAGGKTAGLSLSALRSVSLDTLATILVPELNNNGSNQNKVEMVRLLLRLPDDRGVLPPIGVWPKQKDVADALGLSAGRIPQMLKEERKRWKKDPSVQALRQEIVDLLADLGRVAPAAEIADALAVRRGTQLPEREQRRALALAAVRAVVEMEQLAPESAQFQHQPNRKATEESLGAGLLALDVREADEADGTEGDPPDTPTAPGLLDYATRLGKTADRLAKLDTLPTATTVLGELGALTPPPGAVEWDERRLVELAAAASANAAATPRLEIYPRDLDLVRALRLTQAGLVRLIPGVPEERQPGVTGEDVHERVRARFPELVVPDGRGGGTHDLPTAGPLTKALREAGFDLILATRKDTGTLRYLPARMDTASSYLTTGAWRRSTDVGAVTRYADDPLLADAIRTEERLTASARRDGYRVLTVRQGMSREAVEELGAEEGRFGAHVVSVTELFLEALHTLVPPGTKPTWETLLKADAAEPGSRNAMKFAEYARTAWGTVEPRIRELLGDGGPGTAPVLLTEASVFARYDAMGVLDRSAQAARHGGRGLWLLVPQSDPAREPKLGQVAVAHQAGLGEWIELPDAWVRNAHRAGAVAENGPEGYEGDVK
>NZ_CP019457.1|WP_077193691.1|6414699_6415122_+|YbaB/EbfC-family-nucleoid-associated-protein
MASPYDERIEELLEEYRRQRQEAGELQQRLREISATGTAPRQTVKVTVGAQGELTGVEFPTGAYRRMAPAELTEAILGAARSARAEALAQAGELMASRLPAEIPAVDFLQGTADLTALLPEQPPMPEAVRAYVEQGRSPE
>NZ_CP019457.1|WP_077193693.1|6415245_6415611_+|hypothetical-protein
MDNELSVDTDRLEGAVPHVRELAGRAESVLKNLGQLKDVGKGWDDALGRAFVEAYQGPAETVQRGLADISHVVTSTADGVHTMGKSFANTEYDNLNLIRSHGVTREPNHPSVRSTPSRGRG
>NZ_CP019457.1|WP_077193695.1|6415621_6432538_+|hypothetical-protein
MGIQIPPEIAWAVSWAAGGDWPKPDEDHVRAIGAVWKGVSHELDRVAAAVDPVTARVLGSVKGAAASAFGSFASRLRQTIPSMAGAADDIGTMSVNTAQQVEYAKYMILAQSAWLAAEIVALASSFYGSALIPAEITAVRVNVQLILRRAFKAVVSAAVTQAAMDAAVQGIQFLKGDRTEWDVQGTALGAAMGAMGGAIGMPISLAGSALAPKLSHTVVGHAVTGAVSGVAVGAATNLAFDAGQDLGLAAGAGAIGGATGWRHRPGGTSPTGVENVEGAPEVPKLSQDVTGEVAASWHTTDGASTGHPSDEPAPAEAAPQTDAASTTGTAPAGGTESPQGERQLAETPSTVSQPTRAEPGADAPVPGNAQAPDATGTHASETERAQTTQDARAATSTASPATAPLPLDGTPGTTGRTTPTASADTRARSATTTGEGHGNSGSQQRDETTTAAPTAGATRPETRAATSPEPASQSTTGGIETERGAATTAPATATRAPGPATDQPEQHAAATAPATSTTSTPPVTVETSRVEPASSSTVASQVPPSVPHSAPEHTTGLPGMEPAAKTAEQPASPHLTDTVVASGTHPVEHGPATAPESPSVTHADPAVVAPPAHQLGKAPGEPPHPGLPGLEAKGMSTQAVQPERVPTQAVRAVAEPSVGETPVRLSSAGTDAARPLPTVAAHDPAAHSPLRTAGGPPRTGESATASHGATANAAAEPRTSTSTPTSAASPPQSTHLQSAAEPARHAAPAHPSADANGQSVHGEPPQGPHHDDRRDPPDGGGDPFPPHPRSEDATVPHPSSSRVPEYVPAPDHAQASPEQQRHWEQAQRELHGAYDGHLTEAAKVAGERAEVRERLDAAFTQWSSRLPEHSPEEFAVAVRRRAEEVVTAELAAEPESRERILGDLHGRLELAAVREAAVRVGMARFERTVDVASRQLTAPGDEFAPQPALSRELVGRAREHLSGVFRDRVEKAVAETYRTPEDVGEALPERTVRGERALDGLTAALPRDLDLRVGFETAWDSADRAVEHTAGTWRNGLDAAGERLLEQTGAAADAGVSEDSLRLLRTTLREQVESDFTAVFSSVDSADDFHGSPQGAVADFNGRFEQRLEELPRRFAVQAAREAAIRTVLDTVHETAGAWHEQGLSRLDKAAAETFGLSGPVPEHLADRVAAEVARGVDGRLLRTRDAETETWSKTFGELTASDRIHDLLTLHSAREHGFRAAEGQAHERVAAWREGHILSDDAAERVREGHAERVREAFDEVFPTPDALHGDGVADRLQRWRETRQALDDDLAVHLAFESEVMPALEGAARGFDALAADREPIPFAELSDLKERYGEEWFTEYREHWGPDRLDADKWLAHEAAHENTFRVADGDDPADHGSAQSLTRLDGGPALIGGHPEHTGEAVSSSVVVPREHRPAEEPSGREPDGTDVRPHAVPDPDGGSPSHEADRWPVSHAPEGDARSEVFPELPAKYAKSELEELDQNSRWRILAGEDPLFIAQFQDGSVIGEYSENGPLIGRVGDVEGNLHGGDGGIPTPAWNWYDHNGTFLGSSDGRTEILPAVGEASQIPPASLPYVAGRAVDPGAIHPTPVWSKPSDADIYRNSEYAPGKVFAEGFPPKGVSIPHLVDYVFNGPQDTVFVSATTMNDYVEQTMKQTGRATKYRHIYAIDPLGGIDINATLDIASPFPDQQEIVFPGGVQSRFIKYAQELSTVDGTPVGDRIPNPHYRPLTEEERAAHRPQPGPPERPDTLDPVTPGGRVANFAAPDTWTHRSDNAPSALLHSERFDPAGNPLDPSRFPGTLSGAQTLIRAQVRRIQADNGTWVRDHTVALPVRLDRTVTPHDLTTLNTRLQEALDAHVNTGYALPRSGDQLHVTLHLVHDDHHPEHLVLSRTPGPAPTDQRHWYLPQDSNDPAPLSKFTHEVLHYLGLPDEYLKENFLFRSDKERPAVHSDDALMVQADRFTPLPERYLTVIENTVDTNTVLRDHPLTPRSENDPVQASHNPATDSPTGRWSMARSPESEESSSGQSQHSVEQLPTDAEAVGEGPHAQDEVHTAGPAVARRLAGPLRERIGESAVPDEVLAEVEAYDRLKDSQLTEQRRRLENIDSRLPDTAEDFRETVRGELEHVRGALDFLRWSSGTPEGPYELMTRQGLLWSQESFAMNTAAVGKTGKGYFDELSAMHLQSLRAETGAISGDDAEWYNAMRQPLEQELNGFMLRHYTRSDRVPALLADGLLKSKSKIEADSGGAHNTDPFDDHVMANTGFVFFFIEAPDNQFRATRFGDARITVDLAKSGLLSSGWVMLSDFSAREFPTLMAKHTGDPDVASFTGSKRKFLLDRSDSTRKPSWEQLRIFKRGAGMGAASLPDVSSLQLTKERRQQLSHIRMQLVDEAHGRQVYSNGRQRVERPEPLHHNVLVGPDIVPGLVERTLAEVARISEVDPQIGRALRQKNARQLARFLLKDVVRPQVMVPNSVPVARENIEHKPEEHTTREPQPGPPEQSATPPAGDAVSSGGTVPREHRPAEEPSVQERGGTDVRPPAAPDSDGGSTPHDVDRWPTSPAPEGAARSEPTSGESFRAIGEISFGQGSKRPGEDQLAKIKDFSDSVAAEAVRRVTHDEKPLRVYVEGGGNGSKFQSIRGTSGKADAGLERARAVWDELRSRLNEEISRLWSGDPDILTGTSLLQAPRSRGQGESAAPFPETPVESLTDAEARAARRTVRIWAADDGPARVLRLLAHDGTQLDADRREALVDYVDESARRGQDARVRLLLRRLELRNLRVLRDELDRRYAERVAAIATPADALTPVPKDIHFFWIGKEPSAGALNNLEAWARSAGGRWQQHLWTDAGYSEWSGEVRTRLDRIVTVRPDSLAALSMVDRPKVLEVYETAVAKRAYNLASDIARYVILERSGGVYADVDLHPGTVDLSSMAELTMRPEDLPLLAPRVRDMVSVADALAKAGEAAPTNRNEQVDLAARLRWDAGVLGNHLIVAPPGSEFITSLLDRIPENFAALREHMAVSFGGASPFLEELKNLAPQISGPGMIDDRIPGGKGFPPLQRFAMKAGAQGVAEFDGSSYPTFQRNEAIALFSPRVLEAFQGIRWVTAESERQLDQPAVQQSAAGPSVAMAPLHVPEGPSDALPRAASPYHDGWPSAMDAPRMHGPASSTLPHRGWNHAPRFVVQSAFDVRSFRFGDTPVTDLTVRIAFRNASTHDADAIWQLVKPGVDEFFNRPDYHLPDSSRLHVTVDRVTADQDAHLTVDVVGHDRLMDQRNWWPDAKPIAYAHELAHQLGLRDEYQEGGASGRAQIIGSLMGDFWGAAPDGLPQGGLRGRHLQLLGALVGDNHDQRVEHQSASGPATETPPSTPGGPSSNGSAPAGAGHLQGGGSALLSEDPRWHTVRSTVSPTLREHTWVDPVTDPVQRPASSPGRVVHGPKLPPPDSPVRAADDSEIIDSWRAESALPRARRSEALRRIDTAVDEWANGGRRLRGDHETNQRQLGAVVDAVEAWRSGKTGPSGRTEAVDRLTAHVQSELRDLHHRIAERAHQAQLRDQYARIHPEVSDFAGRRLPGRVDPVNNTAHNIFTGDRTAHGALSDDALDAADDYSRLQLAAKQDRAAAGGVTVDAGVSDARVRELMDGARNDLTGSMVYPELNSYLDRAHQGEALDTGSHLGHLTPVVEDVHGTRVTVHGDPTDSLRDARVDNFRKAVTTVQEAGFHVPDVELHLPKYGRLLEVHHDLIAERSGGRLQRAEYLAPNAVIASPDVVGNPLTGKLADGRYRYLSTELDPSGVGTMVHELGHFLHYANARAQYHDLAFTQFAGRSGQDGDAVAHENLAFGVSAYAAGNPREFVAEVFTGLVYGKPFSPEVMRMYHGLGGPTLTSNRAPYVAPHATPGGPAVAPRGPQPPPVDGLRLDTHPASAPDTAPGPVAPPSSERRPPWYVDHGAHGGIEVAGAARWERERVDTEAAAVAGALTGLPGSPAHQQELRAGIERELRELFAADSGERWSERLREGRMAEVAGQTVWLRPALREVTPAEGPPHPDGAVQHQVYYGSAKVSSGAERETRSALNAALTTVLTVGATGLSAVAGPVPQASVGGSTKRSHTDGFEVISGRTPKTTGSTDFAAQLHVEVSVDGEVAPHDVVTPRGLTVRFPEVFSSAQEPRPDAVAHPMRPVSPDAPHLTRAPLTLQAMDTGPVVAGLVRELRRAGIPADTVAVMMPKFIKELAGEDIVRTRSRFWMTTGDSSGLFDESTSVMRRFTGRFTASTLWERAQYVGTTAVKIQEDLGLVAHDKHGRAATGEGRIGGGVDVLGMGATDNGHLGNLSVGASAESSRTVSLGVNSSREAHTVLTRHEDHARYHVQARVEVVTHSETHRDVRPVHATVATEILVPLRAAAEFERRMFGEVVTEALRPGEAGSHPAGVDAIAPAQLAAGRGQGFGKLIGLPGSERVYGELRRQLDSMMAELRRPPSLADRSRLEALLTTYYGRPALEGDLGVVLAGLDQRLSIGGESFDVSARLHLRDRLEGTETYAMTMDGKAVSRAGMQAQRSHGIGLSASANGSAQLKVSDRFKVRMGKFQVGGSWNRATGNTLSVETKNHRRTQTTGLVHELAYDAVWEVGVHHPKADAHWWIEDRGNMAAVFAVPDEHTPAHDTSTRDTTALDTPARAADLSHSADPDPVPTGAGYGAVRTLTDWPAAAHIPFEHHSGAVYPVFLHTDELLPAAVEQYRRVNGILPGALRERWQFPLELRHSMNSSALHTEFDALASPDGWHVPLDPHKNWKQALRLRLRAYDPVHHGRPDVSIERALQGRDRTTDSSRSGHGWQLTGQLGVHVRHDTNEVLAGVTASGSTSRQLQHEAQHGAGGQTRATYTGPVHAYRSDVVLEVTAIRWKGGTTESETTYLHLTRGMDSLVPHRLVSDLGLPVPEHVQARMDGDDQTPVPRRGPHRLLDDGVTEVPLLRYRERALGVLTGHVEQLHGAGVLTHIQQVLRERGLLPHDAEPRPNLRMQALRHRFSEEALAGNLPALLGNGVHAWMPITGAFGQTHFVAIRVTAKAFEAVEHWTRPETTLMSGGERSTVLSDKQVVASDRKITGEAEARGSVGSVKFGGGGEAGWLSKSSDTRWTSKNTKDVFRLKTREGSHEFTHPLRYRVEIDVAAQGPHAVHWMGTRVRDGVLTLGSLSARFLGTGNDVAAFWYGHQVGSWRSDSAAEGKVIDGSLRTLVPDHLTSGQPRAPIDPEAALIDRGHTLGKRVHWHTGDRPAPGPVETELAAHLVPKAFPAGEAVARWAALTTLPPRQRPADLGLSGAWQVPGLGLDSKYGMRLRLSATDGALRAHSGELLGHTYHLPLRDVGSVTVGLRVVRAQQVAEAPFKDRSYAEVEELPLAFRNRARGWDVAGRSYASGPGADRAELRGTGGLSHGRVRGASEEDETRLDYENNAVTSRALRYYGFDVQAFLIGPYGTLAMEVPGGLYGMLPTEVAEGLHAAHPDLFHGPVPTAEAKGKAPEAAALDDLMAGWEPPAAGSSTAPVRHLADRLRDAGLAEGSAPLRLRAGGPAHVADLARQAAQSLGRPIDLVLDSGLEQRLVPDGTDRSGAATPTGSVGLPSGPAQDTDPARSEAAPAAVVTEVPAPGTEPPSPGELPA
>NZ_CP019457.1|WP_077193696.1|6432905_6433955_+|polyprenyl-synthetase-family-protein
MTPATAPQAAASQTLARCRELVQPALVEAVERLHPWLAEMAAHSLGWTRTQGSFVPGSQGKGVRQALTVLCAEAAGAPAECALAGAVTVELVHTFSLVHDDLMDGDETRRQRASTWKAYGPGPAILAGDAMCALAAQILCESPAAQAGAAVRHLADALHDMARGQADDLFFEFRSWTGPDAVRVREYRSMAEHKTGALLGCATGLGAVLAGAPAATVAGLTRAGRHLGVAFQAVDDLLGIWGDPQDTGKPVHNDLRRLKKTYPVLAALATDTPAAGQLMGILESGGTPGDADARRAADLIEEAGGRAATQREAQQHLDRAHDCLTALDLEPTACDEIRALLPFLIHRRA
>NZ_CP019457.1|WP_077193697.1|6434236_6437137_+|tetratricopeptide-repeat-protein
MAALRIAALGPLRAWRGERQLDTGPAQQRAVLTSLTLRCGQVASTDELVRDVWGAEPPASAHVAVRNHVSRLRTVLESESGAPKALVSVAGGYALHLPDGALDVSQAESLYARAQAARSQGDLEPAVRLLTEAEALWEGTPLTGVPGPYAQRQRDRLVEYRLRLVEARLTLELQLGGHARVVGELLTLADEHPLREELRALQMLALYRCGRQADALAGYTAARRHLAAELGVDPGPELVRLHQRILEADPTLAPPPDVAAASPAPGPAAGPDRPSWVPPAQAPPDVPDFTGRREESRQVRDALAGAVRTDVTAPVICVIHGMGGVGKTALAVHAAHAVREQFPDGQLYVDLRGAGREHADPYEVQELFLRAMGVLAGNVPRGREARTALYRSRMADRRLLLLLDNAADTEQVSPLLPGTAGSAVLITSRTALMCLPATTRTALEPFSESEALDLLERMAGSGRCRQEQQTARDLVQACGMLPLAVRVVGARLVARPRWTLATLAERLSDRSQRLGELEAGSLAVESVFQLGYSTLDDAEARAFRLLAIPEMPDLSPAAAAAVLRCDRREAEELLESLAHHGLLEPGEPGRYRYHDLLRLFARHRTLDTDPSTTRQAALSRVARFYLTGTSSAMRAERPYSRLPDTADPDGLPGTAAFTDARHAQEWVLHELPAMLAVAGQILHHPYRPVSAEDTRTLSGLLALLMPFTDFRLPWDAIHQLAHTLLRAADHHGERLATVFSCVAAAAACAQVGHHEEAAALAARAHETLDPADRALAPRVVYTMGVVAGARPDGLDAAIAHYRNAHALSCESGEPGMAAQCSVSLAHAQLALGRPYQALEAARDALAHCPPGDSPVGLALAQRVLGDALTQLGRYEEAVTEYGTALAVCREHGLHAQRAHTLLALASVLAAVGRPDQARTCAAEGGAALAQLGDPTGEERARAFINRLAAAGPSDLQEQRTAARTEQ
>NZ_CP019457.1|WP_077193698.1|6437427_6437853_-|hypothetical-protein
MGFIKSTTVTQVAEAVGQSDPLARPVVTLGVGSGRHPFLWALLSAGIADSDTFFVTLTDRSVLFHEVTSAGYRPGKLRYDIAHEQVRARIGEVRRRFLWSTFRFRFPGDTEAVWLNVKRAWRPEMDRFLAALRQDSPGRPS
>NZ_CP019457.1|WP_077193699.1|6437979_6440820_-|AAA-family-ATPase
MLIGRERELSALTRLLGAPWTGGDSALIGGSWGSGKTALLRAALADLRQDPGTCVLSAVADPLERDLPFGVVRRLFEQLGADNDPSEPPFCDGTLDAARMLAPWEQRPDGPAATVTGQDAEALGGLYRLIVRLAGERRLLIAVDDLQWADPHSLRWLRYLLRRADNLPLVVLAALGPGDADPHSAAVATVEPLFPHRLTLDGLADDAVEALATQVLGEAPEQSFTVACREATGGNPLLLHAVLRGLRTSGQRPRAELADRITDHVPADLGSAVLTRMQEVDPHAVTTAQAVAVLGGAPGIDLITEVTGLPEPAVADAVHRLVGTGWMTGTEHGLSFVCDVLPAAVAAVVLPSRRRDLHLRAARHLLAHEAPLLRVAGHLLLSPLGEPWVPEVLGRAATLAVEQGDEARAAALLRRALREELTAELRATLLATLGELELTSSLPVAVRNLERSLELSTDPTQQTAIARKLAGALLALDRHPDALETLRRTSEAVRRTDPDQAMRLEIDFIHTSLSEAASAPAVVPRLMELDVSDAAGSPVQRPLAALLSLRAAMTGTSTREVVALARLALSQGMAPEDDESVVYTGAVTSLGAAGETELALSYADAAVRSAHPGISAFHYAHALTTRANIHCRLGRLADCQADAEAALGALDSIGVGPCNGLSTFAITTLAETLLRQGKLADAEDLLVRGDLTGRLNGNWINDYVLMVRGWLRCAQGRLEEGLADFLLCGERTCARGMPNPGFFPWRSEAALVYAALRQGEAARALAEEEVRLARIWGVPEVTGVAVRALGVVVGGRKGLDLLGEAVRLLDGTPARVRYAQALADCGVLARKVGRLSEARAHLRQAVSVAHECGATSLADQALAELRAAGDRPRTRTFHGVDALTPTERRVADLAGRGLTNREIAQRLFVGLRTVEVHLTNVYGKLAIDGRAGLTRALANAATDQEL
>NZ_CP019457.1|WP_077193701.1|6441423_6441858_+|DUF485-domain-containing-protein
MTTHASPPGSTTADAPGSTGTPPATDHLPATVFRAAQQGQPFCQLRRSQRVFAAVATTAVLSLYLLYVLLSSYAPGLMAGKVVGNLNVALFLGLAQFAATFLAAWLYTRHANRRRDPLAEQIKEGIEQARIRAHSHVEAEGTAA
>NZ_CP019457.1|WP_077193702.1|6441854_6443486_+|cation-acetate-symporter
MITPLQQTTLAAAPGADGGRWLTIGLFLAVVAATLGVTLWASRQTKGTTDFYTGGRSFSGFQNGLAISGDYMSAASFLGVTGLIALFGYDGFLYSVGFLVAWILALVLVAEPLRNTGRFTMADVLAFRLRQRPVRTAAGISTIVISVVYLLAQMVGAGSLVALLLGVSGDAPKRWIILGVGVLMILYVVVGGMKGTTWVQIVKAGMLMVGTLVLTVLVMSKFGWNVSSLLGSAAEASGKGHAFLSPGLKYGAGSLTKLDFISLGVALVLGTAGLPHILVRFYTVPTAKTARTSVNWAIGLIGVFYLMTLVLGFAAAALVGHSTIEAANPAGTTAAPMLAEVLGGGPGTTLGATLLAVTSAIAFATILAVVAGLTLTSSTSFAHDLFAHAVRKGKASEREEIRTARFAAVGIGMVAVVLSMFADKLNTAALVALAFAIAASANLPTILYSLFWKRFNTTGALCSIYGGLVSAVLLVIFSPVVSGTPASLVPGADFHWFPLENPGLVSIPIGFLSGWLGTLASRETDPDKYAELEVRSLTGAGAH
>NZ_CP019457.1|WP_077193703.1|6443567_6445523_+|acetate--CoA-ligase
MNNESLANLLHEDRRFAPPADLAAHANVTADTYEKAAADRLGFWAEQARRLDWAVPPTETLDWSDPPFASWFADGHLNVAYNCVDRHVENGLGDRVAIHFEGEPGDSRTITYAELQREVAKAANALTELGVAAGVRVAIYLPMIPEAVIAMLACARLGAPHSVIFGGFSAEAVAARIQDADAQLVITADGGYRRGKSSALKPTIDGAVTKCPTVEHVLVVRRTGEPTVWYGDRDLWWHDVVGRQSTEHHPQPFPAEHPLFILYTSGTTGKPKGILHTTGGYLTQVSYTHHAVFDLKPETDVYWCTADVGWVTGHSYITYGPLSNGATQVLYEGTPDTPHQGRFWEIVEKYGVTILYTAPTAIRTFMKWGDHIPAEYDLSSLRLLGSVGEPINPEAWVWYREHIGGGRCPIVDTWWQTETGAMMLSPLPGVTATKPGSAQVPLPGVAATVVDDEGHEVPNGGGGYLVLTEPWPSMLRTIWGDDQRYLDTYWSRFEGKYFAGDGAKKDDDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPKVAEAAVVGATDPQTTQAICAFVILRGTAAEDEGLVEELRTHVAAELGPIAKPKRILTVTALPTTRSGKIMRRLLRDVAENRALGDVSTLTDASVMDLIQAKLPTAPDED

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	345130-345146	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	2914743-2914759	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	3568060-3568076	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	6495203-6495219	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	7946487-7946503	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	2606584-2606600	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	4254539-4254555	1	0.941
NZ_CP019457_6	6.2\|4408012\|17\|NZ_CP019457\|CRISPRCasFinder	4408012-4408028	17	NZ_CP019457.1	6572518-6572534	1	0.941
NZ_CP019457_6	6.1\|4407967\|20\|NZ_CP019457\|CRISPRCasFinder	4407967-4407986	20	NZ_CP019457.1	2298586-2298605	2	0.9
NZ_CP019457_6	6.1\|4407967\|20\|NZ_CP019457\|CRISPRCasFinder	4407967-4407986	20	NZ_CP019457.1	5631949-5631968	2	0.9
NZ_CP019457_6	6.1\|4407967\|20\|NZ_CP019457\|CRISPRCasFinder	4407967-4407986	20	NZ_CP019457.1	6686916-6686935	2	0.9
NZ_CP019457_8	8.2\|5247581\|19\|NZ_CP019457\|PILER-CR	5247581-5247599	19	NZ_CP019457.1	2943412-2943430	2	0.895
NZ_CP019457_8	8.2\|5247581\|19\|NZ_CP019457\|PILER-CR	5247581-5247599	19	NZ_CP019457.1	6048025-6048043	2	0.895
NZ_CP019457_8	8.2\|5247581\|19\|NZ_CP019457\|PILER-CR	5247581-5247599	19	NZ_CP019457.1	2679219-2679237	2	0.895
NZ_CP019457_8	8.2\|5247581\|19\|NZ_CP019457\|PILER-CR	5247581-5247599	19	NZ_CP019457.1	3453970-3453988	2	0.895
NZ_CP019457_8	8.2\|5247581\|19\|NZ_CP019457\|PILER-CR	5247581-5247599	19	NZ_CP019457.1	4766583-4766601	2	0.895
NZ_CP019457_8	8.2\|5247581\|19\|NZ_CP019457\|PILER-CR	5247581-5247599	19	NZ_CP019457.1	6156950-6156968	2	0.895

1. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 345130-345146, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tggagcggcggccccgg	Protospacer
***.*************

2. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 2914743-2914759, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tggggcgccggccccgg	Protospacer
******* *********

3. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 3568060-3568076, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tggggcggcggccacgg	Protospacer
************* ***

4. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 6495203-6495219, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tgcggcggcggccccgg	Protospacer
** **************

5. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 7946487-7946503, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tggggcggcggcgccgg	Protospacer
************ ****

6. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 2606584-2606600, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tgcggcggcggccccgg	Protospacer
** **************

7. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 4254539-4254555, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tgggccggcggccccgg	Protospacer
**** ************

8. spacer 6.2|4408012|17|NZ_CP019457|CRISPRCasFinder matches to position: 6572518-6572534, mismatch: 1, identity: 0.941

tggggcggcggccccgg	CRISPR spacer
tggggcggcggccgcgg	Protospacer
************* ***

9. spacer 6.1|4407967|20|NZ_CP019457|CRISPRCasFinder matches to position: 2298586-2298605, mismatch: 2, identity: 0.9

ggcttcggcggcggtcagca	CRISPR spacer
ggcgccggcggcggtcagca	Protospacer
*** .***************

10. spacer 6.1|4407967|20|NZ_CP019457|CRISPRCasFinder matches to position: 5631949-5631968, mismatch: 2, identity: 0.9

ggcttcggcggcggtcagca	CRISPR spacer
ggccgcggcggcggtcagca	Protospacer
***. ***************

11. spacer 6.1|4407967|20|NZ_CP019457|CRISPRCasFinder matches to position: 6686916-6686935, mismatch: 2, identity: 0.9

ggcttcggcggcggtcagca	CRISPR spacer
ggcgccggcggcggtcagca	Protospacer
*** .***************

12. spacer 8.2|5247581|19|NZ_CP019457|PILER-CR matches to position: 2943412-2943430, mismatch: 2, identity: 0.895

cggctgctggggggcctgc	CRISPR spacer
cggctgctcgcgggcctgc	Protospacer
******** * ********

13. spacer 8.2|5247581|19|NZ_CP019457|PILER-CR matches to position: 6048025-6048043, mismatch: 2, identity: 0.895

cggctgctggggggcctgc	CRISPR spacer
cggctgctggtggtcctgc	Protospacer
********** ** *****

14. spacer 8.2|5247581|19|NZ_CP019457|PILER-CR matches to position: 2679219-2679237, mismatch: 2, identity: 0.895

cggctgctggggggcctgc	CRISPR spacer
cgactgctggcgggcctgc	Protospacer
**.******* ********

15. spacer 8.2|5247581|19|NZ_CP019457|PILER-CR matches to position: 3453970-3453988, mismatch: 2, identity: 0.895

cggctgctggggggcctgc	CRISPR spacer
cgcctgctgggcggcctgc	Protospacer
** ******** *******

16. spacer 8.2|5247581|19|NZ_CP019457|PILER-CR matches to position: 4766583-4766601, mismatch: 2, identity: 0.895

cggctgctggggggcctgc	CRISPR spacer
cgtctgctgggtggcctgc	Protospacer
** ******** *******

17. spacer 8.2|5247581|19|NZ_CP019457|PILER-CR matches to position: 6156950-6156968, mismatch: 2, identity: 0.895

cggctgctggggggcctgc	CRISPR spacer
cggctgctgctgggcctgc	Protospacer
*********  ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019457_6	6.1\|4407967\|20\|NZ_CP019457\|CRISPRCasFinder	4407967-4407986	20	NZ_CP020331	Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM593, complete sequence	209172-209191	1	0.95
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP016617	Microvirga ossetica strain V5/3m plasmid unnamed1, complete sequence	649840-649871	6	0.812
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NC_003903	Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence	68084-68115	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NC_003903	Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence	287909-287940	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP021031	Rhizobium sp. NXC14 plasmid pRspNXC14a, complete sequence	279778-279809	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP009405	Mycobacterium avium subsp. hominissuis strain OCU464 plasmid p78K, complete sequence	50538-50569	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP006988	Rhizobium sp. IE4771 plasmid pRetIE4771b, complete sequence	184369-184400	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP026745	Nocardia cyriacigeorgica strain MDA3349 isolate MDA3349 ancestor plasmid p_unnamed, complete sequence	11254-11285	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NC_021909	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1e, complete sequence	350543-350574	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	501590-501621	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	95123-95154	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	MH616782	Microviridae sp. isolate ctbf966, complete genome	1674-1705	8	0.75
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	MH834601	Mycobacterium phage BoostSeason, complete genome	29582-29613	9	0.719
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NC_028759	Mycobacterium phage Mufasa, complete genome	29575-29606	9	0.719
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2699444-2699475	9	0.719
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP023712	Rhodococcus ruber strain YC-YT1 plasmid unnamed1, complete sequence	153061-153092	9	0.719
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP013855	Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence	127286-127317	10	0.688
NZ_CP019457_1	1.1\|182316\|32\|NZ_CP019457\|CRISPRCasFinder	182316-182347	32	NZ_CP024312	Rhizobium sp. NXC24 plasmid pRspNXC24a, complete sequence	76443-76474	10	0.688

1. spacer 6.1|4407967|20|NZ_CP019457|CRISPRCasFinder matches to NZ_CP020331 (Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM593, complete sequence) position: , mismatch: 1, identity: 0.95

ggcttcggcggcggtcagca	CRISPR spacer
ggcttcggcggcggtcagcg	Protospacer
*******************.

2. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP016617 (Microvirga ossetica strain V5/3m plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.812

-aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
ccgcatgcc-cccttcgagatccccgacgacac	Protospacer
  .*** ** *** ******** **********

3. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NC_003903 (Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
accccgccgcccgtcgagctcaccgacgagga	Protospacer
* * . ************ ********** .

4. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NC_003903 (Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
accccgccgcccgtcgagctcaccgacgagga	Protospacer
* * . ************ ********** .

5. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP021031 (Rhizobium sp. NXC14 plasmid pRspNXC14a, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gtcgtgttgcacgtcgacatcaccgacgacac	Protospacer
. *.* ..** ****** **************

6. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP009405 (Mycobacterium avium subsp. hominissuis strain OCU464 plasmid p78K, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gccacggtgcccgtctacatcaccgacgacac	Protospacer
. **.  .******* * **************

7. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP006988 (Rhizobium sp. IE4771 plasmid pRetIE4771b, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gtcgtgttgcacgtcgacatcaccgacgacac	Protospacer
. *.* ..** ****** **************

8. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP026745 (Nocardia cyriacigeorgica strain MDA3349 isolate MDA3349 ancestor plasmid p_unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
caggaactgcgcgtcgagatcaccggcgacac	Protospacer
 * .  *.** **************.******

9. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NC_021909 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1e, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gtcgtgttgcacgtcgacatcaccgacgacac	Protospacer
. *.* ..** ****** **************

10. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
atcgtctcgccggtcgagatcaccgacatggc	Protospacer
* *.**.**** ***************.  .*

11. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
atcgtctcgccggtcgagatcaccgacatggc	Protospacer
* *.**.**** ***************.  .*

12. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to MH616782 (Microviridae sp. isolate ctbf966, complete genome) position: , mismatch: 8, identity: 0.75

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
agctcaccacccgtcgagaacaccgacgagat	Protospacer
*.* . **.********** ********* *.

13. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to MH834601 (Mycobacterium phage BoostSeason, complete genome) position: , mismatch: 9, identity: 0.719

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gtgaggtcgcccgtcgaggtcaccgacgacga	Protospacer
.  *  .***********.***********.

14. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NC_028759 (Mycobacterium phage Mufasa, complete genome) position: , mismatch: 9, identity: 0.719

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gtgaagtcgcccgtcgaggtcaccgacgacga	Protospacer
.  *  .***********.***********.

15. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.719

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
gcgaccgcgcccgtcgtgatcaccgaggacgg	Protospacer
.  *.* ********* ********* ***.

16. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP023712 (Rhodococcus ruber strain YC-YT1 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
ggtgtaccggccgtcgagatcaccgatgacca	Protospacer
....* *** ****************.***

17. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP013855 (Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence) position: , mismatch: 10, identity: 0.688

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
ctggccgcgcccgtcgagatcccccacgaccg	Protospacer
   ..* ************** ** *****

18. spacer 1.1|182316|32|NZ_CP019457|CRISPRCasFinder matches to NZ_CP024312 (Rhizobium sp. NXC24 plasmid pRspNXC24a, complete sequence) position: , mismatch: 10, identity: 0.688

aacatcccgcccgtcgagatcaccgacgacac	CRISPR spacer
cgatggccgccagtcgtgatcaccgacgagaa	Protospacer
 .    ***** **** ************ *

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019457

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection