CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019605	Tessaracoccus flavus strain RP1 chromosome, complete genome	11 crisprs	DEDDh,DinG,cas3,WYL,csa3	6	4	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019605_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_1

22453-22638

Orphan

Consensus_repeat	Method
GGAGTTACCGCTGATCGTCGAGTTGACGAT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP019605_1

>merge|NZ_CP019605|1|22453-22638|CRISPRCasFinder
ACGGTTGTCGGTGATCGTCGAATGGTCGATCACCAGCGCGGCGTCCGTGTGGAAGATGGCTCCGCCGTGCCACCCGGCAGCGGAGTTACCGCTGATCGTCGAGTTGACGATGCTCAGATCGCCGGCGGTGCGGATGGCGCCACCGGTGTCGTTGCTGGAGTTGCCGCTGATCGTCGAGTTGACGAT

>NZ_CP019605|1|1|22453-22638|CRISPRCasFinder
ACGGTTGTCGGTGATCGTCGAATGGTCGAT	CACCAGCGCGGCGTCCGTGTGGAAGATGGCTCCGCCGTGCCACCCGGCAGC
GGAGTTACCGCTGATCGTCGAGTTGACGAT	GCTCAGATCGCCGGCGGTGCGGATGGCGCCACCGGTGTCGTTGCT
GGAGTTGCCGCTGATCGTCGAGTTGACGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077339326.1\|18011_19181_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273616
NZ_CP019605.1\|WP_162274591.1\|32107_32233_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380093
NZ_CP019605.1\|WP_077339322.1\|17041_17572_+\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|234759
NZ_CP019605.1\|WP_040284067.1\|26966_27194_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077339337.1\|26068_26431_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077339339.1\|27216_27855_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236191
NZ_CP019605.1\|WP_077339333.1\|20468_20804_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|316153
NZ_CP019605.1\|WP_077339324.1\|17763_17994_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077339318.1\|15931_16546_+\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NZ_CP019605.1\|WP_077339349.1\|32234_32834_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP019605.1\|WP_077339320.1\|16585_17032_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NZ_CP019605.1\|WP_077344132.1\|20826_21465_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_CP019605.1\|WP_162274448.1\|25397_25790_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077339328.1\|19267_19942_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334588
NZ_CP019605.1\|WP_077339345.1\|31284_32025_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP019605.1\|WP_077339343.1\|29107_31237_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236191
NZ_CP019605.1\|WP_077339331.1\|20037_20472_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_040284068.1\|26691_26970_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_143028275.1\|15371_15818_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077339341.1\|27871_28414_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077339326.1\|18011_19181_-\|hypothetical-protein	gnl\|CDD\|273616	TIGR01426, Glycosyl_transferase, glycosyltransferase, MGT family. This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance].	1.9311e-58
NZ_CP019605.1\|WP_162274591.1\|32107_32233_+\|hypothetical-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	6.81886e-09
NZ_CP019605.1\|WP_077339322.1\|17041_17572_+\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|234759	PRK00431, PRK00431, ADP-ribose-binding protein.	2.67262e-76
NZ_CP019605.1\|WP_077339333.1\|20468_20804_+\|transcriptional-regulator	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	4.3192e-13
NZ_CP019605.1\|WP_077339339.1\|27216_27855_+\|hypothetical-protein	gnl\|CDD\|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	1.29099e-30
NZ_CP019605.1\|WP_077339318.1\|15931_16546_+\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	6.76778e-23
NZ_CP019605.1\|WP_077339349.1\|32234_32834_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	2.04816e-24
NZ_CP019605.1\|WP_077339320.1\|16585_17032_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	1.56112e-49
NZ_CP019605.1\|WP_077344132.1\|20826_21465_+\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	4.83526e-63
NZ_CP019605.1\|WP_077339328.1\|19267_19942_-\|hypothetical-protein	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	4.61353e-14
NZ_CP019605.1\|WP_077339345.1\|31284_32025_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	2.85102e-05
NZ_CP019605.1\|WP_077339343.1\|29107_31237_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	0

>NZ_CP019605.1|WP_077344132.1|20826_21465_+|MOSC-domain-containing-protein
MILSTNVAVSQRDPGGADRVSGIDKRPQPFIDVRAPGPSYGDGSGVDGDTVGDSAHHGGAQKAVYAYAREELDYWQAELGRELPNGSFGENLTTVGLDLAAMLVNQRLHIGTAVLEISIVRQPCRTFAAWLGERGWVKRFSQRGRCGAYLRVIAPGRITAGDVIEVVGRPEHDIDMLTAFRAAQGDKEAARSVVAANCLPPLYHRRLVKLVD
>NZ_CP019605.1|WP_077339333.1|20468_20804_+|transcriptional-regulator
MTQVEARFDELIHFPARLRVCGLLRNVDALAFRVLEEALQLPAPQVSRHLKALSEAGYVTVSKTASSERSDARRVAWVCLTPAGRQALDGHMAALEQIVGGSAAAHDGSSG
>NZ_CP019605.1|WP_077339331.1|20037_20472_+|hypothetical-protein
MEPHSPEHASAMLDQLRDDRVRLNAMTETPWWVPIALGLITGVWVASPAVGDRTVGYTMALVSVAVLVLLARRQMGVKLRISGASVWVLAVIWLAITLTAYSVALGLISLQLTAWVAVPALAAAAVTVGMARSIDRRARAAAAS
>NZ_CP019605.1|WP_077339328.1|19267_19942_-|hypothetical-protein
MRLRPYLFVEHDTVVAERHPSADEDVHFSRALVAAVLEDLTQPDDRVLDPFAGFGTTLRVAEAMGRRAVGVELLPERCAAAAAAAPSSLVVQGDARRLTRLVEGPFDLVLTSPPYMASDDGSEDPLSGYRGASSYADYLRDLRSILAQCLGLLSPEGHLVVNVANIDSGVRYTPLAWDVGRLLGEVGRLTQDVFVCWDRPWHDLAGDYLLVARRADAPIGPVGR
>NZ_CP019605.1|WP_077339326.1|18011_19181_-|hypothetical-protein
MARILVAGLPAFGLANPSLPLIRALVDGGHHVDVLQGEAFRGGVERAGATLLPFGFYLDGALTEPRQLIRYGRRLFADMAAAMITLGPRYDALIGTGMQPHLTEVERAVDRPVIFASPVFFQNDRTARHFADIAVGLPAPVRRLLRTPALRRVAGAGAGAAVFGTDVGDIIDLLGMRSSSLNLTVATREYQPYPDDFPGGVFLGPTPTQRRPDPEFPIERVRGHDGPVIYGTLGTVFNTWTPFFRTLADAFAGTDALVVLTTGSREGLARLGEVPENVIARSFVPQTEILERADVCFTHGGFGTATDAVSLGVPPVLTPMGADQFFNAYRLAELGAGVVLPRREFTVEAVRAAADTARHGDRSGLERLRQSFASAGGPALGVRAIESVL
>NZ_CP019605.1|WP_077339324.1|17763_17994_+|hypothetical-protein
MSVKKKFENLPGWLKAIMAVGGTADVVLRVVAMIDIIKRDATEINGPKKVWIPALSAVSSMGILPAAYFRWGRRKY
>NZ_CP019605.1|WP_077339322.1|17041_17572_+|O-acetyl-ADP-ribose-deacetylase
MTTPALEAVLGDITTQRVDAIVNAANSSLLGGGGVDGAIHRAAGPGLVADCRQLRMTELPDGLPTGEAVATDAHRLPARWVIHTVGPNRHAGQSDPALLAACFRNSLTLASSLGARSIALPAVSAGIYGWDADEVAQVAVDAVRSTEAPGVELVRFVLFSARLLDAFKTALAPTAD
>NZ_CP019605.1|WP_077339320.1|16585_17032_+|aminoacyl-tRNA-hydrolase
MSELTVDPGPGIPDGLVIPGGELTERFARASGPGGQGVNTTDSKVQLSFDIATSSVLSDAQRRRALHRLRHRLAGSVLTVESSEQRSQFQNRSAARQRLAAILREALAPPPPKRRATRPTRGSVERRLSSKRKRAETKAARRRPGDSA
>NZ_CP019605.1|WP_077339318.1|15931_16546_+|YdcF-family-protein
MSRSHRAAVVACLGGAGALALLPDLAHRWASAQSYGDRATEGGTEAILVLGCPSRDDGSLHPLQRWRCGIAARTMNPRVHRVVFTGRTGDREVTEAAVMAGYAQTLGIPDHVIVLEEEARSTWENLQYSAPLVEEFDVVRIVSDPMHGWRARQFLARQRPDLAAKLAPARDHRWLERPVLKTGTFVYEVIARYRERRAPRLPVE
>NZ_CP019605.1|WP_143028275.1|15371_15818_-|hypothetical-protein
MTGGCVATPRRALPRRLVLMAAIGSALTACQESDDMSQLPILTDDPMADEALLGLRLLSADEHGYRTALGKPRYAEVTRTFAVGSDPDAILAAAVEEAGASGWAEATPLNQDLMVWQGYKEEPRRTCSISLDRAAEELRLTLTVVEAP
>NZ_CP019605.1|WP_162274448.1|25397_25790_-|hypothetical-protein
MERVMPPAEERFDPITGRWINDPLPDPARAWVNPAGDAPVTTGYGANMPKQPRSRWAIPLVVLTALWGLVLIVMTAFLIAMSLNGQPFSPSALIAGAAVAFGAFTYTASPRRRSGAHMGVTAAPRKGIPQ
>NZ_CP019605.1|WP_077339337.1|26068_26431_-|hypothetical-protein
MTIPPQVGAAATWTLADSERVTATSTTVTIEVTRAECSSGMTGAIAQPVVSLGIDDIIIQVDAEPLPGNEPQNCQGNDSVQMTVSLHEPIGDRALVDAACLKGPAVRTSFCETGATRWSP
>NZ_CP019605.1|WP_040284068.1|26691_26970_-|hypothetical-protein
MMTMPRTVDEILQHADELAARFESYEPNPDDELDAGAVALLRAAVAERSEAERHVIDAIRTAREAGMPWSAIGAFVGTSGEAARQRYASKVA
>NZ_CP019605.1|WP_040284067.1|26966_27194_-|hypothetical-protein
MEDPVIAPSALKHGLGEHEILHAYRNPVRIWDLGDGFTMIVGPNQSAIFLEVGYVDGDQVHVIVHAMKAREKFLR
>NZ_CP019605.1|WP_077339339.1|27216_27855_+|hypothetical-protein
MSGSSVGNIQEAADPVGDAVDFACEFPELVEAIIENFPDHSAIDGEIIMIDPESGDRLNFDALQQRIHPAESRIKKLSAAMPASFVAFDLLALGQTNYVNAAKTVASNNGSLASNGSEYYRRTCAAARVISMSLQAVVADLGGRVAGDAANALSQQLDQARSSSTVLSPGSWPTGTQGGAAGPDNMNTVSNPQNVDTSSATTGPTDTTGVNY
>NZ_CP019605.1|WP_077339341.1|27871_28414_+|hypothetical-protein
MSPKRIVVAAALSLLTACSPTADPSESVSESAQPTTVSPSASASPASSASASTSDYDWGAMPPRGFDTAPALTGSLPAQVGEWAGEPRVSDFGTVIDYKSGTKSVEADWWEQGQSTYKQAVEEMTDAAYVGENTCGTVDELFSVCIRVLANGAYKAQTLDLTVDELATLTDELIAAAVSG
>NZ_CP019605.1|WP_077339343.1|29107_31237_+|ATP-dependent-DNA-ligase
MPCRGRRTWTRRPPRRVLWPDDGYTKRDLADYLVAVSEPFLRLGGDRPMTLQRFPEGIDGEEFFSKRPPRGAPSFLRTVTCTYPSRRRHDQLVFDEPAALAWAAQMGTITFHPWPVRTADLDNPDELRIDLDPQPGRDFRDAVTAALALRDVMAEAGLKAYAKTSGNRGIHVYARIKPTHEFQDVRHGVIGIARELERRMPELVTSAWWKEERGERVFVDFNQANRDRTIAAAYSPRPLPGAPVSTPLTWDELPDADPREFTVATVPGILAKRACAWADIDDHAGDVAGALKLWEADLERGLGELNFPPDYPKMPGEPPRVPPSKRKADRADDEYLAPKAERDAEWGTAIAPPYGPMLAKPVKKLPEGEYLYEPKWDGFRSIIWRSGDMVEIGSRNSRPMTRYFPELVEAIIENFPDHSAIDGEIIMIDPESGDRLNFDALQQRIHPAESRIKKLSAAMPASFVAFDLLALGQTNYVEKPFRERRAALVEALKDAEPPIHLTKATDDPAEAERWFEQFEGAGLDGIIAKPLDEPYVEDKRVMFKLKHERTADCVVAGYRLYKDEKDAIGSLLLGLYTEDGQLNSVGVIGALPMARRKELFEELQPLVTTFEGHPWAWAQPEEVTPDNRDQSFPRTPTAAAHSRWNAKKDLSFTPLKPERVVEVRYDHMEGDRFRHTAQWVGWREDRDPESCTYEQLEEPVSYDLGSVLG
>NZ_CP019605.1|WP_077339345.1|31284_32025_+|hypothetical-protein
MEERRLDERRSNANVWIIVGVIAVLGAIGLYVLLTQPGDGPTASPTPTVTVTSTAVSTETAPAEPTQATTEATVTETATESASAPATSEAPSPSPVEETSEAAAEPPDEDWGEFPPQNYATAPTLGTNIPDTVGEWTADPATSDHHSDGSAVAYGKGDQVLSVRYYNDSFWQWGATVANFENPAYVGDFVCGTLPAADGLRLSASCLAVTKTGMLQFTQPAAEGGEAPIEALAANATEILGLLAQG
>NZ_CP019605.1|WP_162274591.1|32107_32233_+|hypothetical-protein
MRAKAAKLVAAGADVVEEFRQPPQGEWIVMEDPEGNEFCVV
>NZ_CP019605.1|WP_077339349.1|32234_32834_-|class-I-SAM-dependent-methyltransferase
MSSTTRPTPDGSSLRQTLAVLTAAAEDLGFVQSSEGDLGRLLRLLVASRPGGSFLELGTGVGYGAAWLLDGMDADSRLVSVELEDDLQRIARATFDDDPRVEWVLGDGSEWLREAVARPERFDVVFADTWPGKYHDRDLAMELVKPHGWFVLDDLYPQPGWPDGHQANVDRLIADMQSVDGWRTEFLPWGSGLMLCVRD

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Crispr_ID: NZ_CP019605_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_2

798976-799116

Orphan

Consensus_repeat	Method
CTCTTCCTTGGGCTCGGG	CRT

3 spacers

The CRISPR arrays of NZ_CP019605_2

>merge|NZ_CP019605|2|798976-799116|CRT
CTCTTCCTTGGGCTCGGGCTTCGGCTCTTCCTTGGGCTCGGGCTTGGGCTCTTCCTTGGGCTTGGGCTTCGGCTCTTCCTTGGGCTCTTCCTTCGGCTCGGGCTGCGCCGGCGTCGGGTCGGTCTCTTCCTTGGGCTCGGG

>NZ_CP019605|2|1|798976-799116|CRT
CTCTTCCTTGGGCTCGGG	CTTCGGCTCTTCCTTGGGCTCGGGCTTGGG
CTCTTCCTTGGGCTTGGG	CTTCGGCTCTTCCTTGGG
CTCTTCCTTCGGCTCGGG	CTGCGCCGGCGTCGGGTCGGT
CTCTTCCTTGGGCTCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077340714.1\|806940_807300_+\|iron-sulfur-cluster-assembly-accessory-protein	unknown	unknown	gnl\|CDD\|272875
NZ_CP019605.1\|WP_077340701.1\|803157_803487_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077340708.1\|804890_805670_+\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NZ_CP019605.1\|WP_077340716.1\|807538_808291_+\|cytochrome-c-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224537
NZ_CP019605.1\|WP_162274479.1\|803637_804294_-\|DUF3043-domain-containing-protein	unknown	unknown	gnl\|CDD\|378611
NZ_CP019605.1\|WP_077340697.1\|801327_801627_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077340704.1\|803431_803638_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_093664664.1\|795372_796311_-\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NZ_CP019605.1\|WP_077340677.1\|786790_788968_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP019605.1\|WP_077340679.1\|789175_790597_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_CP019605.1\|WP_077340687.1\|794611_795367_-\|DUF4191-domain-containing-protein	unknown	unknown	gnl\|CDD\|379389
NZ_CP019605.1\|WP_077340691.1\|797162_797897_-\|DUF554-domain-containing-protein	unknown	unknown	gnl\|CDD\|377371
NZ_CP019605.1\|WP_077340685.1\|792847_794605_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP019605.1\|WP_077340681.1\|790790_792143_-\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|366058
NZ_CP019605.1\|WP_077340675.1\|785069_785468_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077340689.1\|796503_797163_-\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|184638
NZ_CP019605.1\|WP_077340683.1\|792387_792816_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP019605.1\|WP_077340712.1\|805998_806883_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NZ_CP019605.1\|WP_077340699.1\|801617_803123_-\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863
NZ_CP019605.1\|WP_077340695.1\|799819_801220_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235798

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077340714.1\|806940_807300_+\|iron-sulfur-cluster-assembly-accessory-protein	gnl\|CDD\|272875	TIGR00049, Uncharacterized_protein_in_nifU_5'region, Iron-sulfur cluster assembly accessory protein. Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.12304e-47
NZ_CP019605.1\|WP_077340708.1\|804890_805670_+\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	6.09621e-28
NZ_CP019605.1\|WP_077340716.1\|807538_808291_+\|cytochrome-c-oxidase-subunit-II	gnl\|CDD\|224537	COG1622, CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion].	2.88983e-61
NZ_CP019605.1\|WP_162274479.1\|803637_804294_-\|DUF3043-domain-containing-protein	gnl\|CDD\|378611	pfam11241, DUF3043, Protein of unknown function (DUF3043). Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.	7.1208e-42
NZ_CP019605.1\|WP_093664664.1\|795372_796311_-\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	6.37763e-179
NZ_CP019605.1\|WP_077340677.1\|786790_788968_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	4.86325e-85
NZ_CP019605.1\|WP_077340679.1\|789175_790597_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP019605.1\|WP_077340687.1\|794611_795367_-\|DUF4191-domain-containing-protein	gnl\|CDD\|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	1.48945e-86
NZ_CP019605.1\|WP_077340691.1\|797162_797897_-\|DUF554-domain-containing-protein	gnl\|CDD\|377371	pfam04474, DUF554, Protein of unknown function (DUF554). Family of uncharacterized prokaryotic proteins. Multiple predicted transmembrane regions suggest that the region is membrane associated.	5.95934e-69
NZ_CP019605.1\|WP_077340685.1\|792847_794605_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.54372e-161
NZ_CP019605.1\|WP_077340681.1\|790790_792143_-\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	2.35504e-100
NZ_CP019605.1\|WP_077340689.1\|796503_797163_-\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|184638	PRK14345, PRK14345, lipoyl(octanoyl) transferase LipB.	1.26077e-91
NZ_CP019605.1\|WP_077340683.1\|792387_792816_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	2.56435e-05
NZ_CP019605.1\|WP_077340712.1\|805998_806883_+\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	6.23834e-12
NZ_CP019605.1\|WP_077340699.1\|801617_803123_-\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	1.93477e-178
NZ_CP019605.1\|WP_077340695.1\|799819_801220_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	7.30424e-170

>NZ_CP019605.1|WP_077340691.1|797162_797897_-|DUF554-domain-containing-protein
MFIGIGTVVNVATVVVGALLGLALGNRIPDRTKETITSVLGLFTVVIGGMSVVSMTSADLTGAVGSFAMIIVLASLLVGALVGSWLQVEYRLEQGATWLRGRFTASGDAARFVDGLVTSTLVFCVGPLAILGSLSDGLGRGAEQLLVKSVLDGFAAMAFASTLGWGVLASAGTVALIQGSLTALGYFAGDVLTVAQVDALTATGGVILLGLALRLLDLKQVPVGDLLPALLLAPPLVSVAAAVL
>NZ_CP019605.1|WP_077340689.1|796503_797163_-|lipoyl(octanoyl)-transferase-LipB
MLTFEYLTASGPLDYYQVWDHQRAVHATVADATRPGHVILVEHAPVYTAGRRTKLSDYPKDGTPVVPVDRGGEITYHGPGQLVGYPIVPLRDGVGVVDYVRALEGAVIDLLEGYGLSAGRVPGRTGVWLPAEGERPERKICAIGVRVARRTTMHGFALNVLSSAERFCNIVPCGIADAGVTSLVEELAWPWSVSAVAEALEPHLRRALEMVSSGGVSSS
>NZ_CP019605.1|WP_093664664.1|795372_796311_-|lipoyl-synthase
MTAVKPDGRRLLRVEAKNAETPIERKPAWIKTTAKMGPNYSDLQTIVREGDLHTVCQEAGCPNIYECWEDRESTFLIGGDQCTRRCDFCQIESAKPEGYDPSEPLRVAASVKKMGLRYATVTGVCRDDLADEGAWLYAETIRQIHAVNPGVGVEMLAPDFSGKPELLGQLFDARPEVFAHNVETVPRIFKRIRPGFRYERSLEVLTMSRSAGLVTKSNLILGMGETRDEISQTLRDLHDAGTELITITQYLRPNATLHPIERWVTPEEFDELADEAREIGYSGVLSGPLVRSSYRAGRLYRTAMDARNTMQR
>NZ_CP019605.1|WP_077340687.1|794611_795367_-|DUF4191-domain-containing-protein
MASERAKELAAKQKAELKAMKEAKKNSTNPADWGRWRQLTETYKVTAQYDKQLPWFMIGSFVLVFALLLVVGFLLDSPLIWGILGVSAGLLAAMGIFAIRARKAIYRRYEGQAGSAEVALQMLPKKWVSTPVITATRHMDAVHRTIGPGGLVLIGEGDPGRLRPLLASEKRKHEQVAYGVEVKTIQMGKGAGQVPLDKLADHIKKLPKSLTPAKIVEVNQRLRALDAMRPKAPIPKGVINTKGARSAMRGR
>NZ_CP019605.1|WP_077340685.1|792847_794605_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MANLVNLESVTHGFGTRILLDDVSLGLGAGEVIGVVGRNGDGKTTLLRILTARLTPDAGRVTISNTASIGVLTQETIGDDHQSIRDWIVDGEPDHVWAADSDKRTVVESLLADLELDRRLDTLSGGERRRVGLAAVLLGHHDLIVLDEPTNHLDVEAIAFLASYLQGRVKAGLAMLVVSHDRWFLDAVCTRIWEVHDGVVDAYDGGYAAYVLARVERQRQASANEARRKNLARKELAWLRRGAPARTSKPKFRIDAANQLIAGEPEPRDKIALQAFAVTRLGKDVYDLINVDYAIADRVLLDKLTWSIGPGDRIGLVGVNGAGKTTLLDLLADEREPHAGKIKRGKTIRLAYLSQTVGELDDEDRVLASVKRLKEETKLATGRDASASSLLEEFGFTGDKLVARIGDLSGGERRRLQFLRLLLTEPNVLILDEPTNDLDIDTLTVIEDYLDSWPGTLIVVSHDRYFLERITDATYALLGDGSCVMLPGGVDEYLDRRARAKSAPPAPATAPAGKSDAAAERQRKKDLTRIESQLDKVTGQIDQLHEAMTAHASDFEKLAELGAELRTAEARRDELEEAWLETAEP
>NZ_CP019605.1|WP_077340683.1|792387_792816_+|RDD-family-protein
MTDTPLSPGESIGLPAVGPGSLASWRSRVAAMIGDWAASMIVATLIFGSEVLVGNDWRSFMILTVYFVEASVLTALTGASFGQLIARIGIIRLDGQPLGWWRPVVRTALKCLVIPAIVIGAERRGLNDLLLGTVVVNRRPAA
>NZ_CP019605.1|WP_077340681.1|790790_792143_-|dicarboxylate/amino-acid:cation-symporter
MSTSLSERRSERAVEPRKPFYTGLGFQIIVGLIAGLILGLVALSLGPTADGERNWLTTTLSEVGSAYVKLLMLLVVPLVVTAVISSISRLTQVANAARLAVQTLLWFAITALASVIVGILVGVFSAPWLTAGVSGDAAAEPSRVGSWTAFILGIIPSNFLGLGVNASASGEGAVTASPSFSVLQILFVSILFGIAAVKVGDKAAPFIGFMESALSVIQKVLWWIIRLAPIGTAALIGRAVATYGWSSLASLGAFVVALYVGLAIVWLVVYPTILKLNGLGVRQFYRNAWPAITLGFFTRSSMGTMPVTEQVIERNLGVERGYASFVAPLGATTKMDGCASVFPAIAAIFVANFYGIDLNVTHYLLIAFVAVLGSAATAGTTGATVMLTLTLSTLGLPLEGVGLLLAVEPIIDMGRTALNVTGQALVPTIVGKREKVLDRGIYDAKPVFSA
>NZ_CP019605.1|WP_077340679.1|789175_790597_-|type-I-glutamate--ammonia-ligase
MFNSAEELLAYIRDEGIETVDVRFCDLPGVMQHFTVPASFFGPEVFEDGLSFDGSSITGFQKIHESDMALMPDPTTAYVDPFRKSKTINVNFFVHDPLTKEPYSRDPRNIARKAEAYLASTGIGDSAFFAPEAEFYVFDDIRFETTANSSYYHIDSEAGAWNTGRVEDGGNRGYKVKFKGGYFPVAPVDHFGDLRDDIVRHMGNAGLQVERAHHEVGTAGQAEINWRFNSLLKSADDVMKFKYLVKNTAWEAGKTATFMPKPIFGDNGSGMHVHSSIWNNGEPLFYDEGGYAGLSDMARWYIGGILKHAPALLAFTNPSVNSFHRLVPGFEAPVNLVYSQRNRSACIRIPITGSNPKAKRIEFRCPDPSSNPYLAFAAILLAGLDGIQNRIEPMDPIDKDLYELPPDEHAQVPTVPASLGAVLDELEADQEFLLAGDVFTPDLLETWIELKRAEIQAIAMRPHPHEFELYYAL
>NZ_CP019605.1|WP_077340677.1|786790_788968_-|MMPL-family-transporter
MTTNRFARIAIPLALIIVWLVGAGIGGPYFGRVSEVATNDQATFLPTNAEATVVGERYLDFVDSSSLPAIVLFSSDDEALSPETLGELSATAESLAGIDGIISVSPLIPSEDGLAAQAFALVDSDGDIADIVGELRAELESSPSGVTTHVTGPGGFTADITEAFGGIDGLLLIVALVVVLVILLIVYRSVVLPFAVLVTSTFALCVALLLNWWLAKADIITLTGQTQGILFILVIGAATDYSLLYTARYAEELKRRESKGEATKAALKGVIEPILASGGTVIAGLLCLLLSDLGSSRSLGPVASIGIVFAMLSALTLLPSMLYLMGRASYWPRRPRFDPARGDDAQLSDGIYAKTAQLVSRRPRLVWVLCVIALAAGAAFVPTLRADGVPPSEFVIGPSEARDGQAELSEHFPGGSGTPAQVLTDEDQLQEVASALLASPGIASVDVVSEASPSGSAPVTDQGVQPLGPPGTPAPEPTISEGQVMLLATLADAPDSDEATQVVRDLREQLSGTAQIGGETATNIDTRDTSIRDRNVIIPLVLAVILVILIFLLRSVLAPVLLILTTVLSFGTAMGTAAIVFNHILDLPGADPSVPLYGFIFLVALGIDYNIFLMTRVREESLIHGTREGIKRGLAVTGGVITSAGLVLAATFAALAVIPILFLLQLAFIVAFGVLLDTFLVRTLLVPALSYDIGPAIWWPARLKADTQGRHGLVESGPRHALIED
>NZ_CP019605.1|WP_077340675.1|785069_785468_-|hypothetical-protein
MSVSLRLQRTVSCLLAWCLPLIGNRLALMVAPAGEGQHVDMFGITSVQFQAALIGTAVGAAAGVAVIVVRKLGWRWLAVAVPLVIAGTWAAGALEETPLVTDGRPIVLAAMLIAPIVAAWVTQPPRGTRHAR
>NZ_CP019605.1|WP_077340695.1|799819_801220_-|FAD-dependent-oxidoreductase
MSDAYDLAILGAGSAGYACALRAATLGLSVVMIDEAEVGGTCLHRGCIPTKAWLHAAKVRRTVSKAPSFGIGAELGDTDAEAIRAYADGVVSGLHRGLTGLLKSRGVTVVAARGSLEVSDAGPAIRTPDALHRASAVLVATGAAPATLGFDIDGERILTSNHALRLSTLPETAIVLGGGVIGVEFASLWADLGVSVTLLEATDRLLPGEEPGHVRVLRRELERRGVDIRLGAPATSAEATDGGVRVSAGSDSVSAELLLIAAGRRPVTSGIGLEEAGVTLSPSGHVVVDGNLQTAARNVYAAGDLVPGPQLAHRGYAHGIFVAERIAHNLGRHPRKPTPVRDVDIPRVVYSSPQLASVGVTLEAAGAGADSVDYHLTGNGRAQILRAPGERESGVVRMVRAADGRIVGLHAVGEDVSELIAEGALLVGWHATPEDVAGIIHPHPTLSEALAEANWALAGQPLHIHG
>NZ_CP019605.1|WP_077340697.1|801327_801627_+|hypothetical-protein
MSLAREAKQVPDALRDHLSEFVATRRGVEAWVEQPTSFNKPSILLVAADGESTRRGLPSADYGYDFAAAHGVPCYDAGVVPYPRRMREYGLRAKKQGQR
>NZ_CP019605.1|WP_077340699.1|801617_803123_-|leucyl-aminopeptidase
MTRTDPTLNLTKSLPRSADVLLLGLATIHQGDRALVGLSPELGKSYQKAYGRSLAELASAMGAKTALEEVTQLPPLGSTRVFVVGLGDADVTPHGLRGALGNALRCIAGLEDAQGLEVAVSLELSDPELIQAAAEGAVLGAYSFQPITGTAKPSPVASISFITPLTGTEQRTALTTAQHTAAAVCQARDWVNTPPNLLYPESFAEAAKTHVREQKVAVEILDEKALERGGYGGILAVGGGSARKPRLVRLSYAPRGAERHLALVGKGITFDSGGLDIKPAGQMAGMKYDMSGAAAVIAAVNAIAALGLKVKVTAYAALAENLPSGSAFRSGDVLTMFDGQTVENYNTDAEGRLVMADAIARAGQDKPDLIVDVATLTGACMVALGLRTGGLITNGEETSDLLLDAAEAAGEDFWELPLTDATREELKSTVADMKSGAGKRWGGALVAGAFLERFVGDGVAWAHLDIAGPAENPESAYGYVPKGGTGVGVRTIVTLAGLLQR
>NZ_CP019605.1|WP_077340701.1|803157_803487_+|hypothetical-protein
MLKRLGLIAFIVAGLVVAVWGAMSWISPSTSCRGVEMGPGDTCEYSSLTNEKTGEVQRYEDRIAIARQQSPFAVAAGLGMLAFGAVVARSEFRAAVTSVRRPDGPPRTD
>NZ_CP019605.1|WP_077340704.1|803431_803638_-|hypothetical-protein
MSYRWEPVSGAYSADELEAAGLKKSFEDQTAAEEWLALFFGELLTHGVAEVSLYEEDRLVYGPMSLLP
>NZ_CP019605.1|WP_162274479.1|803637_804294_-|DUF3043-domain-containing-protein
MALFRPYERNESAKTDRIQSLTPKGEKAAAKAAAKTAPTAPAAAPEAENPGTRAGIRKKQGATPSRKAAEAARMERLHPTLSPKEQRRADARARSAARMDSWSRIEQSPERQLLRDYVDTRWTVAEFMLPLMILLMALSMISIQAAPQISYYVTLALWPLMIMAIINVAIMWRGFKKLLAERHPGASTKGLLMYMMNRSIMLRRFRQPGPRIKRGDPI
>NZ_CP019605.1|WP_077340708.1|804890_805670_+|PspA/IM30-family-protein
MASIFERIALVFKSKANKTLDKYEDPRETLDYSYQKQLELLQNVRRGVADVATSRKRVELQASKLNSEVERLQSAAQRALESNREDLAREALTRKAGLQTQLDDLQTQHAQLQGEEEKLVRASSRLQAKVDAFRTRKETIKATYSAAEAQTRINEAFTGISEEMSDVGLAIQRAEDKTLQLQARASAVDELLASGALEDPTGTVKDDITRELDMLAADSTVESELAAMKAQLTGGPAARPEIESAPAAQESGDTQGRQA
>NZ_CP019605.1|WP_077340712.1|805998_806883_+|glycerate-kinase
MRVVITADAVAGLSPAAASALIARAFSDRGAQVAVVPLGVSGEPLREALEALAPRTDVVRPDDAAALRQVLQSDRSPLVDLTGTAAPELQGLAAALGTDPGVALEDARERWSDRDLVALVPEEEVALPLVGLNGLAATQGRRAGDDLSTVLARDAEAERWASSLGLDPTLPGAGAAGGLGLIVQALGGRMTDPLTYLADVAGLADTMGAADLVVTAAESLDFHAVGGPIVKRAVAMAGAALRPAIAIVGRNFVSARELRLAGFEEAYPLGAAGEEPTPERLSEVAMRVATTWSW
>NZ_CP019605.1|WP_077340714.1|806940_807300_+|iron-sulfur-cluster-assembly-accessory-protein
MEPSVTDTQTTQSGVVLTDVAVQKVRSLLEAEGRDDLALRIAVQPGGCSGLRYQLYFDDRELDGDVVTDYDGVKVVTDRMSSPYLGGASIDFMDTIEQQGFTIDNPNAQGSCACGDSFH
>NZ_CP019605.1|WP_077340716.1|807538_808291_+|cytochrome-c-oxidase-subunit-II
MFFGLPEAASEQAENVGDLWLGAWVASLVIGGLVWGLIGWAVVRYRNRNGDDAPPRQTTYHLPLELLYTLVPFLIIGVLFFYTVKTQDSVRNFEGEPDVEIGVIGQKWSWTFNYMEEGNPDVGTNAYTVGTLETIPELYLPVDKTIRFKLESADVIHSFWVPVFRDKLDVIPGHTNYLTVTPNKVGTYDGKCAELCGEFHSLMLFKVHVVSEEDYEAHVRGLAEGGNAGERQLQEALQAVLPTAAPEENQ

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Crispr_ID: NZ_CP019605_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_3

1785440-1785514

Orphan

Consensus_repeat	Method
CACGAGGAACGTCCGTCGAAGGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_3

>merge|NZ_CP019605|3|1785440-1785514|CRISPRCasFinder
CACGAGGAACGTCCGTCGAAGGGTGGTCCCTGAGCAGTGACGAGCGCTCTGCGCGAGGAACGTCCGTCGAAGGGT

>NZ_CP019605|3|2|1785440-1785514|CRISPRCasFinder
CACGAGGAACGTCCGTCGAAGGGT	GGTCCCTGAGCAGTGACGAGCGCTCTG
CGCGAGGAACGTCCGTCGAAGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077342229.1\|1786934_1787657_-\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NZ_CP019605.1\|WP_077342240.1\|1793518_1796167_+\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NZ_CP019605.1\|WP_077342217.1\|1782593_1783088_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_CP019605.1\|WP_077344268.1\|1780179_1780899_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_CP019605.1\|WP_077342238.1\|1793127_1793535_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077344269.1\|1787653_1788181_-\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|378626
NZ_CP019605.1\|WP_077342209.1\|1779070_1780180_-\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NZ_CP019605.1\|WP_077342227.1\|1785623_1786874_-\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	unknown	unknown	gnl\|CDD\|183518
NZ_CP019605.1\|WP_077342213.1\|1781426_1781633_-\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NZ_CP019605.1\|WP_077342234.1\|1789779_1790742_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381313
NZ_CP019605.1\|WP_077342231.1\|1788182_1788833_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|163560
NZ_CP019605.1\|WP_077342223.1\|1784214_1785075_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234781
NZ_CP019605.1\|WP_093665116.1\|1781678_1782365_-\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NZ_CP019605.1\|WP_077342225.1\|1785082_1785346_-\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|212154
NZ_CP019605.1\|WP_093665110.1\|1783723_1784218_-\|PH-domain-containing-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342219.1\|1783148_1783634_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP019605.1\|WP_143028312.1\|1798195_1798513_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379233
NZ_CP019605.1\|WP_077342232.1\|1788943_1789768_+\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|237134
NZ_CP019605.1\|WP_077342211.1\|1781006_1781375_-\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NZ_CP019605.1\|WP_077342236.1\|1790780_1791155_-\|DUF3224-domain-containing-protein	unknown	unknown	gnl\|CDD\|371584

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077342229.1\|1786934_1787657_-\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	1.47776e-85
NZ_CP019605.1\|WP_077342240.1\|1793518_1796167_+\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	8.65869e-10
NZ_CP019605.1\|WP_077342217.1\|1782593_1783088_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	1.07303e-12
NZ_CP019605.1\|WP_077344268.1\|1780179_1780899_-\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	4.72668e-61
NZ_CP019605.1\|WP_077344269.1\|1787653_1788181_-\|DUF3090-domain-containing-protein	gnl\|CDD\|378626	pfam11290, DUF3090, Protein of unknown function (DUF3090). This family of proteins with unknown function appears to be restricted to Actinobacteria.	5.4995e-58
NZ_CP019605.1\|WP_077342209.1\|1779070_1780180_-\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP019605.1\|WP_077342227.1\|1785623_1786874_-\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	gnl\|CDD\|183518	PRK12418, PRK12418, cysteinyl-tRNA synthetase; Provisional.	0
NZ_CP019605.1\|WP_077342213.1\|1781426_1781633_-\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	5.54834e-18
NZ_CP019605.1\|WP_077342234.1\|1789779_1790742_+\|aldo/keto-reductase	gnl\|CDD\|381313	cd19087, AKR_AKR12A1_B1_C1, AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR). Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.	3.04849e-93
NZ_CP019605.1\|WP_077342231.1\|1788182_1788833_-\|histidine-phosphatase-family-protein	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	2.43816e-64
NZ_CP019605.1\|WP_077342223.1\|1784214_1785075_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|234781	PRK00489, hisG, ATP phosphoribosyltransferase; Reviewed.	2.37673e-122
NZ_CP019605.1\|WP_093665116.1\|1781678_1782365_-\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	5.81039e-87
NZ_CP019605.1\|WP_077342211.1\|1781006_1781375_-\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	6.14671e-60
NZ_CP019605.1\|WP_077342225.1\|1785082_1785346_-\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|212154	cd11547, NTP-PPase_HisE, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. This family includes M. tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. M. tuberculosis HisE is encoded by the hisE gene, which is a separate gene presenting in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants. HisE is responsible for the second step in the histidine-biosynthetic pathway. It can irreversibly hydrolyze phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate. HisE dimerizes into a four alpha-helix bundle, forming two inferred PRATP active sites on the outer faces. M. tuberculosis HisE has been found to be essential for growth in vitro, thus making it a potential drug target for tuberculosis.	9.9719e-39
NZ_CP019605.1\|WP_077342219.1\|1783148_1783634_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000132637
NZ_CP019605.1\|WP_143028312.1\|1798195_1798513_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379233	pfam13518, HTH_28, Helix-turn-helix domain. This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	0.000192892
NZ_CP019605.1\|WP_077342232.1\|1788943_1789768_+\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|237134	PRK12554, PRK12554, undecaprenyl pyrophosphate phosphatase; Reviewed.	7.87793e-123
NZ_CP019605.1\|WP_077342236.1\|1790780_1791155_-\|DUF3224-domain-containing-protein	gnl\|CDD\|371584	pfam11528, DUF3224, Protein of unknown function (DUF3224). This bacterial family of proteins has no known function.	1.44109e-30

>NZ_CP019605.1|WP_077342225.1|1785082_1785346_-|phosphoribosyl-ATP-diphosphatase
MKTFDQLFAQLTETARTRPEGSGTVARLDAGVHSIGKKIVEEAAEVWMAAEHESKEQAAEEISQLIYHLQVMMIALDLDLDDVNRYL
>NZ_CP019605.1|WP_077342223.1|1784214_1785075_-|ATP-phosphoribosyltransferase
MTTDRLLRIAVPNKGALAEPAAAMLKAAGYRQRTDAKDLTLIDSDHGVEFYYLRPRDIAVYIGRGHLDLGITGRDMLLDSRAEATEIMELGFAGSRFLFAAPGGSSMTIADIEGKRVATSYPDLLAGYFEDKGINAELVKLDGAVESAIRLGVADVVADVVDTGTTLKRAGLELFGDPICTSEAVLIQRNNAELPATAEGLKTRLRSVLVAQNFFMMDYNVDTEHLETTLALAPGVEGPTVSTLAKSGWSAVRVLVPRKGAHLLMDRLYEAGARGILLTELAACRL
>NZ_CP019605.1|WP_093665110.1|1783723_1784218_-|PH-domain-containing-protein
MTEQKVPDRLSYTSAPALMTSVVASAVLLSLALYGWWALGPGIRAQVTIAQAGTLLFFVLVMIGVMLSVGYSRLWAQDGVVTVRNGPFVRRYPVSEIAGFRLRPGDAWSSLLIKDDGDLKRKPVLAVQFLEGERGQRKVRELRRWLVEQGATSQGYDANRVDDN
>NZ_CP019605.1|WP_077342219.1|1783148_1783634_+|hypothetical-protein
MALDFIITLALAIGILAIAAGLTARSRRARPAVAGLGLAMIPVGLYLTGLTTLIINGVRSIIDWLMRTPWTDAISWGIGLLVGGIVLLVIAGFLPREAKPRPVHPDARATAPAKQASTAPGQRPVAPPAKPGPAPATAKSKAAADPEDAEIEELLRKRGIM
>NZ_CP019605.1|WP_077342217.1|1782593_1783088_-|SseB-family-protein
MTELRSLAQPSARFAGDDGAPDPLTRAAIARADDRTGYTRAIVALCSSRLLLPIVASGDDTDHPDPDRHAEMAAVTLADEGSDYLLAFTGYDSLRAWQPDARPVPCHLDELCATVEPAGASKLLLDVAGPVPFVIEGDLLAMLAQGHSLVEFDDGEFAWVTTDS
>NZ_CP019605.1|WP_093665116.1|1781678_1782365_-|translation-initiation-factor-IF-3
MSTEPRINDRIRVPEVRLVGPKGEQVGIVRVEDALRLAAENDLDLVEVAPMARPPVAKLMDYGKFKYEAAQKVRDARKNQSNTVTKEMKLRLKIDAHDYETKKGHVVRFLKAGDKVKITIMFRGREQSRPELGMQLLQRLAEDVAEFGFVEAAPKQDGRNMLMVLGPTKKKTEAKVDQQSDRERRMAERAQKQQEEKAAEAELRAQHTTVAAKKKRGPADNMDPDIDL
>NZ_CP019605.1|WP_077342213.1|1781426_1781633_-|50S-ribosomal-protein-L35
MPKMKSHSGAKKRFKTTGTGKLLRRQANLGHLNEHKSSVRTRRLSSPESVAPADAKKVRKLLGKHKGR
>NZ_CP019605.1|WP_077342211.1|1781006_1781375_-|50S-ribosomal-protein-L20
MARVKRSVNAMKKRREVLEQASGYRGQRSRLYRKAKEQLLHSATYSYRDRRAKKGDFRSLWIQRINAAVRAEGMTYNRFINGLKNAGVEVDRKILAELAVNDTAAFNALVAIAKDNQPAAAA
>NZ_CP019605.1|WP_077344268.1|1780179_1780899_-|RNA-methyltransferase
MFLAEGRQAVREALGSPGRVQEIIVDDAVRHADLLDGLELPVWQADEHQMRQLSDTVTPQGVVAVCRQLDFDWESLDGARLVVICAQVRDPGNAGTVIRCADAFGADAVILTSGSVEIYNPKTVRSTVGSIFHLPILTGVTLAEAVERVKGLGMTVLAADGEGDPLDLKAASGGLSGPIAWIMGNEAWGLPADDARLADEVVAVPMWGQAESLNLSSAAAVCLYATASAQRRETGKGSN
>NZ_CP019605.1|WP_077342209.1|1779070_1780180_-|phenylalanine--tRNA-ligase-subunit-alpha
MSGPNDNFDPKQVAALDASAIERYVHDALEAIAAATSTAELKRARHDHAGDTSPLALANREIGALPPQARKEAGRRVGEARGTVSRALSERQDEVAAAELEASLVVERVDMTLPVTLRPQGALHPVTTLIDEMIDVFVAMGWEVADGPELEAEWYNFDALNLGPDHPARALQDTLWVDPPSGGKLMRTQTSPVQARALLEYGVPLYVISPGKVFRADEYDATHLPVFHQLEGLVVDRGISMADLRGTLDHLARAMFGDVRTRMRPHYFPFTEPSAEVDLECFVCHGASVGNPDAPCRTCKSEGWIEWGGCGVVNPRVLRACGVDPDVYSGFAFGMGVDRTVMFRTGAPDLRDFVEGDIRFSRSILGGSR
>NZ_CP019605.1|WP_077342227.1|1785623_1786874_-|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase
MYAWAPVAVPSLPKSDDSVPGRLTLFDTAAQSLTEVGPNDGAARMYVCGITPYDATHLGHANTYVTFDLVQRVWLDLGLDVDYTQNVTDVDDPLLERAAETGQEWEELAEDQIELFRSDMQDLRVIPPRHYIGAVESISCVIDLIEQLLPSGLVYQVDDDQHPDWYFNTVGAEGFGGVSNLDESRMIELFRENGGDPDRPGKRHPLDCLVWRFARPDEPSWTSSLGAGRPGWHIECTAIAMRYLGPNFDVQGGGSDLVFPHHEMCAAEAIAAAHEPMAEAFVHSGMVGLDGEKMSKSKGNLELVSRLRHAGADPMAIRLALMDNHYRSNWDWTPDKLERATERLTAWRGVLNNATAMPAGETIAAMRTALRNDLNAPAALATVDAWVAASMAIESDDTSAVSDMVQAIDALLGIKL
>NZ_CP019605.1|WP_077342229.1|1786934_1787657_-|SCO1664-family-protein
MKLTLVGRLVDASNGTFLASDEDESLWVYKPVAGEAPLWDFPEATLGRREVAAHALSEHLGLGIVPLTVWADGPLGEGSVQAWVEGEPTDTIALLRPERIDENWLPILAAEDEDGAPVVLAHSDDGRLRTVAVFDALLNNSDRKASHLIAAGAKLFGVDHGVSMHVDDKLRTVLWGWAGDPLSDAELALCSDVASLTAPLAPGLDDDEWEALRRRAKALLEAGTMPMPSGRWPGIPWPPL
>NZ_CP019605.1|WP_077344269.1|1787653_1788181_-|DUF3090-domain-containing-protein
MAGMMLEFNRPDRCIVGTVGSPGNRLFLIQVAEGGQLAAVAIEKQQAQMLGIRIKEVLEQLAELGHDVPDEQPPADLGPLDAPLEVTFRAAAIGLAWDHERQRLLIELMAGPEDESDENALLQVLLTPAMAREFAARAEVVVASGRPPCPACGQPLEGSSHICPRANGYRGPLFP
>NZ_CP019605.1|WP_077342231.1|1788182_1788833_-|histidine-phosphatase-family-protein
MTKVVLIRHGRSTANAAGVLAGRAAVALDEFGRAQAEALREALSGVQVAAAYTSPIERCRETAALAGFPDAEVADGLSECDYGDWTGLKLDELMKEQVWTDIQARPTEVSFPGGETMTGMFDRVSAAIDELTGRHADDETIVAFSHGDPIKGILAHAFGMRRDDFQRIHVAPAGISAIDYRQPHPMVLCVNVGGALAAHLGVARGPVVGGGDVGRQ
>NZ_CP019605.1|WP_077342232.1|1788943_1789768_+|undecaprenyl-diphosphate-phosphatase
MDWLQAIVLGIVQGLTEFLPISSSAHVSIVGQLLFDGRDPGAAFTAVTQLGTETAVLVYFRKDIWRIITHWIGSLRGTVEKGDPDARMGWLVIIGSVPIVVLGLLFQDAIDTTLRNLWITVAMLAGVALVLAAADRFGERNTKDLRQLSWRDGILLGLFQAAALIPGVSRSGATISGGLFLGFNREAAARYAFLLAVPAVFGSGLYKLKDIGDDTAATWGPTIVATILAFVIGYAVIAWLLRYISTHSFRIFVVYRLVIAAIVAVLILTGVLSA
>NZ_CP019605.1|WP_077342234.1|1789779_1790742_+|aldo/keto-reductase
MQLRPLGASGLQVSRLGLGTMAWGRDVDWPTARELLTEFVEAGGNFVDTAPAYGAGVAERMLGKALAAGLPRETLVIASKAGFVVRDGRRVIDTSRGALLTDLEGTLRRLKTDHLDLWQVHAWGDAPMDETLSALDSAVQRGLVRYVGVSNFVGWQTATAATWQAADRARTTLSSVQVEYSLLARRAEVEVMGAARHHNLGVLAWSSLGRGALTGKYRGGRVPRDSRAASEHFSWFVEPYLQPRSAAIVDAVAHAAQGLGLTPTQVALLWVRDAPQVASALVGPRTVDQLAELLDAEQKELVAPIVSALDDISGGANALR
>NZ_CP019605.1|WP_077342236.1|1790780_1791155_-|DUF3224-domain-containing-protein
MVTNATFVIEITPSEGLLPTTGRFDFTKVWSGGAEGTSKGVMLSSGNAAKGTAGFVAMEVFEGRIGSLSGSVSLQQFGTMVGGEQRLTYEVVPGSGTDDFIGITGELHLTIDEDGLHHVRFDIA
>NZ_CP019605.1|WP_077342238.1|1793127_1793535_+|hypothetical-protein
MEVLGLADGAALVITGMASPPTADEPPGQGTLSLPAEVATWIGEAVAAGVTFEVLKEASVALVRQGWTKKGTTATAESVTQAVVQYLRSCGYIEIVVSEVRRVSGQGWTLTGTADGSRFGGMADDGGNLVHVRVR
>NZ_CP019605.1|WP_077342240.1|1793518_1796167_+|CHAT-domain-containing-protein
MSASDDTWPTPENLRAVQVWLNHLDDLSESQPQAVLDATEAALPLLATWTVSDAYAWTLALRAKTLRFLDRLPDVLDAAESGLGSLRGDEHVAAHLHLEAGMALNQFGRQPEAAEHLKAADRVFESAGDDSGRAWALVSLAEAYAGSGIPTDPEATLRLAIDLADRSGDSRAARRGWKQLAVLHRHRGQPTEALDAIWRALDGDMSAHTRANYLLELGHLKAWTGDYAAADDAYQDASASYADHGDILGQANVERALATNALILGRHIQAAKRLDRAAELYRAIRSTAGLGYVLRERAVLRTTSGDHIGALADTEEGLLCFRNSPDTLGLAGMLRAAARVRHVTGDRAGAGAALAEAHALAAGGKNPLAEAGLLSLSAEIGDTASLRLAAGTESARLYRRMGIPTGEAFALSHAARAHADLGDVDRAVATIREATAVLRSARSQVADPGRRGDHDFALRDVTTNLLKTAERLGGLATLVMADLIVDEAPLGLRNAFNEGQPGARARRFVSRISTMKPPLGETSATRRHLIQELGALFAFIEPGEDPVWTSFEDLASSHSSGALLAYGAPTRDGHLPIAWQLPGGRPHVDLVGLDDAAVEQIDALGYAFTADRADVLWVPQNRSWQTHLSQVVLPSPVRRWLTGEESPSLAVLFPPVLAHLPLEALLVDGEPVGLRAAVARLTVPTTATVRATLSQTVAYLDPALPWTPERLALPGFTHDPRQLRAELGPARLLFVACHGESAVRAEGALVASDGARVADALDLVAHPLTGSVIVLEACFAGRYMGPRTGEQLNLATVSLLSGASAAVAGLFALPADDSCTGAIAAALFRELAAGTSAPEALRRARWAYWSERPDHLGVPGQPELSMPGDAPWAWAGLCAYSR
>NZ_CP019605.1|WP_143028312.1|1798195_1798513_-|helix-turn-helix-domain-containing-protein
MGRPPVIPVEKKTRIVLSILAGEMTIAEAARREKVSEQSIGRWKADFLEAGKAGLAAGRSGPSTREQQLEAEVTELTQALGEAAVEIRVWKKSAKGRLGPSRTSR

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Crispr_ID: NZ_CP019605_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_4

1982416-1982516

Orphan

Consensus_repeat	Method
TCCCTGAGCTTGTCGAAGGGTAACGGCCCCGATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_4

>merge|NZ_CP019605|4|1982416-1982516|CRISPRCasFinder
TCCCTGAGCTTGTCGAAGGGTAACGGCCCCGATCCCTACCGCCGCCCCCGACCTCAGGGCAGGCTGCTCCCTGAGCTTGTCGAAGGGTAACGGCCCCGATC

>NZ_CP019605|4|3|1982416-1982516|CRISPRCasFinder
TCCCTGAGCTTGTCGAAGGGTAACGGCCCCGATC	CCTACCGCCGCCCCCGACCTCAGGGCAGGCTGC
TCCCTGAGCTTGTCGAAGGGTAACGGCCCCGATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_169835162.1\|1993488_1994853_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_CP019605.1\|WP_077342495.1\|1973941_1974181_-\|DUF2188-domain-containing-protein	unknown	unknown	gnl\|CDD\|378323
NZ_CP019605.1\|WP_077342499.1\|1975375_1976143_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342509.1\|1979846_1980737_+\|fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|180045
NZ_CP019605.1\|WP_077342531.1\|1991344_1991764_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_169835162.1\|1989221_1990586_+\|IS1380-family-transposase	unknown	unknown	gnl\|CDD\|379340
NZ_CP019605.1\|WP_077342505.1\|1978375_1978960_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP019605.1\|WP_077342533.1\|1991766_1993137_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372888
NZ_CP019605.1\|WP_077342523.1\|1986221_1986668_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342491.1\|1971068_1971443_+\|sulfate-permease	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342493.1\|1971515_1973834_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379114
NZ_CP019605.1\|WP_077342513.1\|1982836_1983343_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342517.1\|1983528_1985286_+\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|274140
NZ_CP019605.1\|WP_077344283.1\|1976251_1976494_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342519.1\|1985336_1985666_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP019605.1\|WP_077342497.1\|1974215_1975373_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_CP019605.1\|WP_077342507.1\|1978978_1979695_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NZ_CP019605.1\|WP_077342511.1\|1980750_1982355_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP019605.1\|WP_077342521.1\|1985662_1986196_-\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NZ_CP019605.1\|WP_143028264.1\|1988345_1989074_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077342495.1\|1973941_1974181_-\|DUF2188-domain-containing-protein	gnl\|CDD\|378323	pfam09954, DUF2188, Uncharacterized protein conserved in bacteria (DUF2188). This domain, found in various hypothetical bacterial proteins, has no known function.	4.65089e-12
NZ_CP019605.1\|WP_077342509.1\|1979846_1980737_+\|fructose-bisphosphate-aldolase	gnl\|CDD\|180045	PRK05377, PRK05377, fructose-1,6-bisphosphate aldolase; Reviewed.	0
NZ_CP019605.1\|WP_169835162.1\|1989221_1990586_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	7.11139e-79
NZ_CP019605.1\|WP_077342505.1\|1978375_1978960_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.22998e-16
NZ_CP019605.1\|WP_077342533.1\|1991766_1993137_-\|hypothetical-protein	gnl\|CDD\|372888	pfam14040, DNase_NucA_NucB, Deoxyribonuclease NucA/NucB. Members of this family act as deoxyribonucleases.	1.76385e-06
NZ_CP019605.1\|WP_077342511.1\|1980750_1982355_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	9.05903e-69
NZ_CP019605.1\|WP_077342493.1\|1971515_1973834_-\|ATP-binding-protein	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	1.04794e-11
NZ_CP019605.1\|WP_077342517.1\|1983528_1985286_+\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|274140	TIGR02456, Trehalose_synthase, trehalose synthase. Trehalose synthase interconverts maltose and alpha, alpha-trehalose by transglucosylation. This is one of at least three mechanisms for biosynthesis of trehalose, an important and widespread compatible solute. However, it is not driven by phosphate activation of sugars and its physiological role may tend toward trehalose degradation. This view is accentuated by numerous examples of fusion to a probable maltokinase domain. The sequence region described by this model is found both as the whole of a trehalose synthase and as the N-terminal region of a larger fusion protein that includes trehalose synthase activity. Several of these fused trehalose synthases have a domain homologous to proteins with maltokinase activity from Actinoplanes missouriensis and Streptomyces coelicolor (). [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP019605.1\|WP_169835162.1\|1993488_1994853_+\|IS1380-family-transposase	gnl\|CDD\|379340	pfam13701, DDE_Tnp_1_4, Transposase DDE domain group 1. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	7.11139e-79
NZ_CP019605.1\|WP_077342519.1\|1985336_1985666_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.17931e-21
NZ_CP019605.1\|WP_077342497.1\|1974215_1975373_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	4.52389e-17
NZ_CP019605.1\|WP_077342507.1\|1978978_1979695_-\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	3.60535e-89
NZ_CP019605.1\|WP_077342521.1\|1985662_1986196_-\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	1.21648e-22

>NZ_CP019605.1|WP_077342511.1|1980750_1982355_+|NAD(P)/FAD-dependent-oxidoreductase
MIRECDAVVIGAGHHGLVAAALLADAGWDVIVLDARSKVGGAVASTTIDGFVVDEFSSNHPLGKASPVLRDLELERHGLTWVDHRPSVVHVADEDDGAGSAIESTPEETAAALDADHVGDGDAWLKMCTGWERVREPLLHALLSGWPPVRAGAGLARRLGAAGLLDFARFALLPSEQMGREWFGGQRARDLLAGNAAHADVSPLAPVSGMMAFIMTMLAQDVGFPTPRGGSGELAGALARRAQVAGADVELDTAVAGITVTAGRADGVQLADGSRIRARRAVVADVSATALYRGLLPADEVPPGLLARLERFVWDPPTLKLNLQLSSTMPWLAANARRAAVIHAGASSDTMPRWHLEIAMGRVPDKAFSLVGQMTTADPTRSPAGTESLWAYTHLPVDSVDPVGANTASLRSLESMFDRLAPGWRDIEQGRWLQTPQDLEAANANLVDGALGAGTTQLFQQGPWRPVMGLGGPITHIDGLYLGSAATHPGGGVHGGAGFNAARAALRDARWWSKPIGRSATRVQRMLHRQDPDF
>NZ_CP019605.1|WP_077342509.1|1979846_1980737_+|fructose-bisphosphate-aldolase
MFEQQLHKMRDAEGFIAALDQSGGSTPKALRLYGLESWADDEEMFDKVHEMRTRIMMSPSFDGKRILGTILFQDTLARQVDGRPTADYLWNVKGIVPILKVDKGLLDMEAGARLMRPMPDLDAVLAAALEQGVFGTKMRSVILEPGGGLAAVVEQQFDVGEHIFRAGLVPILEPEIDIHSPLKAEAEEQLHDALLSHLDQLPDDHWVMLKLTLPETDDLYLDLVRHPRVLRVFALSGGYTRAEANERLARQHGIVASFSRALTEGLSVHQSAQEFDALLDESIRSIFDASRSPMEV
>NZ_CP019605.1|WP_077342507.1|1978978_1979695_-|TatD-family-hydrolase
MKTALGIAGVVQASGDVESSRWAVDAAASDPRVLAAVAIHPNDAPTYAAEGRLDEAIAVIDELAAHPRTRAIGETGLDYFRTDEPGRPAQHESFEAHIALAKKHGVAMQIHDRDAHDDVLETLTRVGAPEKTVFHCFSGDEAMARVAADAGYWLSFAGNITFKNAQNLRDALQVTPLERILVETDAPFLTPVPLRGRPNAPYLVPLTVRFMAAELDVDVDELCTQLAANTLAVYGSFA
>NZ_CP019605.1|WP_077342505.1|1978375_1978960_-|GNAT-family-N-acetyltransferase
MRFLDETTLQDAFVRLEPLDHAHADELSRAAATLTPAWYTSVPTADEVPAEIDRRLALREAGAMNPFAVRRLHTGEVVGMTTFCTIDQPNRRVEIGYTWIGAPAQGTEVNPAMKRLLLGHAFDACDAIAVALMTHFHNRQSRAAIERLGAKLDGILRSHRIMPDGSLRDTAAYSILPHEWPAVRSGLDARLAER
>NZ_CP019605.1|WP_077344283.1|1976251_1976494_-|hypothetical-protein
MHRATVFSHLRRRNVPSRRPGLGIDEKAEAVRLARAAVSMRAIGRRMGVDRKAVREALAEAGLIVDCTNGARRSGLPNLI
>NZ_CP019605.1|WP_077342499.1|1975375_1976143_-|hypothetical-protein
MTAKEDPVVQQHDSDDWRGEFQPAELAALRERIPTAIQRSQERSARAQAAYDDPDGDQDVYGAGMARGVQKELRTLLSDLPSYREAKIPTTRRMLTFVGNTLIFAQRVGKQMPRNFRRVRLSYLPDSRRELLSKTSNVKYSDPGLFDISDVLEGDQPASLEDALSHVELAVPRTTLFVPYYSSTPQGVGTIYFAPARLNGRYLEFADPERLTYERTPSSVDAPRTMLKPVAGFNSGDRPRTSVKLRQRRSEQEGS
>NZ_CP019605.1|WP_077342497.1|1974215_1975373_-|ImmA/IrrE-family-metallo-endopeptidase
MAMAHDGNVDLAGVARMFDPARLAQARRISKMSKADLHRKVGVSAAAIGQYERGEVRPRAETVAALATALGVPPGFFALGRPRVQVDIAEASFRRLRSTTVTQQQQATAYVEQAWELSCYLEESVEFPELDLPAWAHADSFDVPDPATAARAMRQHWLLGTGPIEHLVYQLEQHGILTVFFSMKEDASLDEKSRIDAFSTIALPRPMIVLTPDKANDVMRHRFSAAHELGHIVLHHGRQGTDSQLERQADMFAAEFLTPRDVIRDQLPRRINFNRYEELSQLWGVSINSLIFRSRELDLISESTARRAYITLNGIARRPMPVHDYPGERPELLKSALELLDQAGVPLTQVAEDLQMTPRHIRRLADIDDPQPKLTLVNDRPDRRK
>NZ_CP019605.1|WP_077342495.1|1973941_1974181_-|DUF2188-domain-containing-protein
MTGPNKRVVQRRSDGDWEVRKPGADRASVVTSTQAEGIQRARTILGNDGGGELQVRSLKGTIRAQDTIAPGNDPRSSKG
>NZ_CP019605.1|WP_077342493.1|1971515_1973834_-|ATP-binding-protein
MRIREVWVRFYKSFNFDYELKATPGSKAKPWQQLEDGWMPHVRVPIEPDITAVVGANESGKTHLLDAIRIALTGEGLLQRDFCRSSSLFSVEHGSRLYPEVGLTLTPSEGEASVLRDNNIPVRKNGDLLMLRPAPGVTAVVGSDEERVDLTSTQAAALQALMPHPHELKTEVALPDSVSISALAHDGSRFRSRSERKRLLDIISSFTSTNDVTANAASLVPSDLEDTEAAAQQLGVDLLVGVARIEESSFQELQKAIAEEREGLVNGLIQEMNNSIARHLNVSRWWTQDPEFQLRVSPREHELVFTIRDRTGTDYSFTERSRGLRYFLSYYVQLLAHDRPAELPEVLLMDEPDAYLSASGQQDLLRVLEHQARPDDSDREDQVIYVTHSPFLINRNAGHRVRVVDKGARDEGTRLVKDATRNHYEPLRTSLGAFVAETAFIGGDNLFVEGISDQVLLAGMNARLLRLGTPPSQCLDLNQVTIVHGGSNVPYMLYLARGRDQIKPACAVLVDGDDAGQTMRKQIRRGGAHGKPTVSDDLIIDLAEWAAAASLTVTDGVRVREPEDLVPVSVAVAAARRYARNFLGLDETSYKILTEDSVTNLISDKDGSLWDALAAAFRTAFDTEIGKAGFAKELLAYLTDSEADGGPRPPGVPALDSHFGALLLKLTDTLTLARERENDARRDQRLERIIDTFTADHPIGCTRDRAAVVLKRIDAAVDDTFAGDVIHAGTTRLRREFKLATEPLKNVDDYAGFLEQLKNLRHLERLNHQGVV
>NZ_CP019605.1|WP_077342491.1|1971068_1971443_+|sulfate-permease
MIRLLWTASAEVRYFLRRYMPSNIVLDLIRTRKGLKWGIPAMLLAGPYLAIAFWCTTLIESGGPGWLHLVVLLCIWNALKMLAIGPVSLSLLVRTRVRERHARMHINQETRDEPQLPELTRSGQ
>NZ_CP019605.1|WP_077342513.1|1982836_1983343_-|hypothetical-protein
MQRIELDHDKYSAYLNQHLVAADAGVKAFKAAADTWEGTPLQAVFEQLHRELEQSHDKVKALIERLGYDVSMTRNLVAGVAHVAGRLNPLNFTRNSDGLMTQMEFDALAAAVRAQQMMWETLVVLSDVDDRLDRAEMQAMVDLCEDQRARVVKASAETAVERFTAVPG
>NZ_CP019605.1|WP_077342517.1|1983528_1985286_+|maltose-alpha-D-glucosyltransferase
MPEPGVIPQPATPVTPPSPTPVAPDTAPVPVPSVGRALSDDPLWFKKAVFYEVWVRSFADSTGTGTGDLNGLIGKLDYLAWLGVDCIWIPPFFRSPERDGGYDVELFTGIQVQLGTHQGMKRLLDEAHARGIRVISDFVLNHTSADHPWFVSSREDPQGPYGDYFVWRDDDSGYPDARIIFVDTEESNWTFDPVRKQFYWHRFYSHQPDLNYDNPKVVEEILDALRFWLELGVDGFRLDAVPYLVEEEGTNCENLPGTHAILKQIRAMVDAEFPGRMLLAEANQWPKEVVEYFGEGDEFHMAFHFPVMPRLFMALKQGSRKAISEILADTPPLPEGCQWATFLRNHDELTLEMVTEDERQYLWNEYAPVQKMRLNLGIRRRLAPLLDNDERQIRLLHALLLALPGSPVLYYGDEIGMGDHIWLPDRDGVRTPMQWTSEVPGAGFSDANPYLFNQPIPCTPPYGAPDVNVADQQADPDSLLNWLRHILAQRRAHEVFGLGDFTELECTDAVMAFERSQGSTRVICLNNLTAWPQLAVLELDGLHGRVPAVLSGSVGDAPEVVETNYRIELPPYGYMWLLFADPPPM
>NZ_CP019605.1|WP_077342519.1|1985336_1985666_+|thioredoxin-family-protein
MSLGYEDEQPTRDAVDAMSGEVALEFGANWCGYCRAAKPHLDAALDRRPGVRRVKVADGKGLPLGRSFGVKLWPTLVLLRDGQEVGRVVRPTDRSDVTAALDAAGFSGS
>NZ_CP019605.1|WP_077342521.1|1985662_1986196_-|DUF421-domain-containing-protein
MWYSSLDPILRVLMVGPVAYLLAVVAIRISGKRALSKLNAFDLVVTVALGSMLATILTSSDLALATGLTGIALLLGLQVVVSLITSRFVKGQTAVRAEPTLLVRRGELLEEAVVSARLTEAEVLQAIRAAGFGGLDQLAAVCLESDGSLSVVGSDSLGDGTALSTVGSWDSDPESGR
>NZ_CP019605.1|WP_077342523.1|1986221_1986668_-|hypothetical-protein
MNRFTVRLPAQCPAHEALGRVLDLRVHNQVIPLTTITPARAFCELRPGSSFVARTAVGRFGFDDPMVVEHIGMVPGRAVARLRKEGCAIRGQIRVDCRDTEDGGSTLTWHQDVHLPWWPRSLHWMATPVLRAGYRRVLRQLLARPHGT
>NZ_CP019605.1|WP_143028264.1|1988345_1989074_+|hypothetical-protein
MDRRWPVASVVSRLGSQAVLVNGRDEDVFKQPDGHAARRAARDSDGPVYDELDGPVLRPEPVGLSGLWRRRIAQGLVWVGRAVMVAWPLGFVVTRLTSGIWMSASSEDGLPVHPITDVMMGLSFIFAMGVPVFLLPVASGVWLYPRGDGTVRVPTVLGTRVLEADSVSTRPLFELPGRGWGITVTLVRDRTSRWFLMADSGLWHDEEGSIVLGMLAILAWSAVTVLVWAVLIELTFLGTPSH
>NZ_CP019605.1|WP_169835162.1|1989221_1990586_+|IS1380-family-transposase
MSVTGDGGAVIAHAGSIGLRMLAENTGLTGALSTAMARRSFIPSVHDRGQVLTDVAVMLADGGEAISDIDVLRHQGQVLGPVASAPTVWRALDEVTDARRRKIQAARARVRRHVWAQLTAAGGVPASKVAGTDLGETIVLDVDATIVVTHSEKELASPTFKRTFGYHPIGVWCDNTGEFLAAALRTGRAGSNTAVDHIQVLGEAITQIPMPYRRNLLIRCDGAGASHQLLDWLHAQGQVRGRTLHYSVGFTIGEKVRAAITELPAGLWSPALTAEGEVREGGDVAELTGLLDLTSWPAGMRVILRRERPHPGAQLSLFEVHDGWRYQAFATNTTSGTLQFLEARHRAHARVEDRIRHAKDSGLGRFPSREFAINQTWLALTMIAADLVAWLKMLALDGDLAKAEPKALRYRLLHVPARLVHGARRRRLRLPKTWPWVEHLVAAFARIAAIPPPH
>NZ_CP019605.1|WP_077342531.1|1991344_1991764_-|hypothetical-protein
MIPLTGPNSEILFLVRTDFSDDDAWHRVDEVAGREGTNVETVNDPANRHLDAATLASELPTFAQGVLLADHVTMTTSEQLVLVYPTRYDEDEDEVAPFRAPAALLAYVVCPIVLGSRNWSEVGGLVNQDGVFSMDHPRP
>NZ_CP019605.1|WP_077342533.1|1991766_1993137_-|hypothetical-protein
MKRWLQLIFVGLIAGAMLSPMSAHADTLDENTLDENYSVPAAEPVAPASLTPPTTETYFTDLDGTTDTTKPTLLPAVEPATSTTSRASAQLPGDCAQVRQLIAEKKVSANTLCWGVEEETPIATRNATIISNCRTMAPNGTSWVAFSRFYACYHAKSTVTFYRPATLSIEGRIPIDFYQAVQLDPQSLSVTTASEAKVGPRQGAHGSIASIKLTTDTCTGCSVVNSATTKSGSSLYTSSATMSVNSPGVNARRIAGTSLKLEITAAVNFPFFLWNKTVFRQSRGVLWDCDTEPIGNLKAPGCVFGGITGTVLFDGRTPENGGPMYTTAIHMSDAMNSGLPGKIGSGKYLTRTNSVTIRDANRNAACPRSLIRPPGGYECDEFPFASTLEGGAANTKEARTFWYCNLSDPQRTGPLGFSRCMTPPGEGSFQGGALNSGYMNQRIRNGDKFAVGWSQV
>NZ_CP019605.1|WP_169835162.1|1993488_1994853_+|IS1380-family-transposase
MSVTGDGGAVIAHAGSIGLRMLAENTGLTGALSTAMARRSFIPSVHDRGQVLTDVAVMLADGGEAISDIDVLRHQGQVLGPVASAPTVWRALDEVTDARRRKIQAARARVRRHVWAQLTAAGGVPASKVAGTDLGETIVLDVDATIVVTHSEKELASPTFKRTFGYHPIGVWCDNTGEFLAAALRTGRAGSNTAVDHIQVLGEAITQIPMPYRRNLLIRCDGAGASHQLLDWLHAQGQVRGRTLHYSVGFTIGEKVRAAITELPAGLWSPALTAEGEVREGGDVAELTGLLDLTSWPAGMRVILRRERPHPGAQLSLFEVHDGWRYQAFATNTTSGTLQFLEARHRAHARVEDRIRHAKDSGLGRFPSREFAINQTWLALTMIAADLVAWLKMLALDGDLAKAEPKALRYRLLHVPARLVHGARRRRLRLPKTWPWVEHLVAAFARIAAIPPPH

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Crispr_ID: NZ_CP019605_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_5

2265388-2265473

Orphan

Consensus_repeat	Method
GGCAGCCCGGAACGCCAACGGAGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_5

>merge|NZ_CP019605|5|2265388-2265473|CRISPRCasFinder
ATTAGCCGGGAACGCCAACGGGCAGCCCGGAACGCCAACGGAGGGTACACCGACGCCAACTGGCCGGTCGAAACGCCAACCGGCAG

>NZ_CP019605|5|4|2265388-2265473|CRISPRCasFinder
ATTAGCCGGGAACGCCAACGGGCAG	CCCGGAACGCCAACGGAGGGTACACCGACGCCAACT
GGCCGGTCGAAACGCCAACCGGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077343008.1\|2268477_2269464_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381312
NZ_CP019605.1\|WP_077342996.1\|2262319_2262736_-\|DUF2089-domain-containing-protein	unknown	unknown	gnl\|CDD\|378280
NZ_CP019605.1\|WP_077343010.1\|2269498_2270482_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_093664751.1\|2266708_2268430_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376789
NZ_CP019605.1\|WP_077343014.1\|2271951_2272644_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240040
NZ_CP019605.1\|WP_077344301.1\|2259741_2260332_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NZ_CP019605.1\|WP_077342994.1\|2261743_2262247_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP019605.1\|WP_077343020.1\|2275254_2275767_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342998.1\|2262737_2263532_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077342990.1\|2257685_2259695_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NZ_CP019605.1\|WP_077343006.1\|2265804_2266509_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077343012.1\|2270967_2271852_-\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|225203
NZ_CP019605.1\|WP_077343004.1\|2264586_2265255_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|234604
NZ_CP019605.1\|WP_162274540.1\|2261329_2261731_+\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NZ_CP019605.1\|WP_077343022.1\|2275789_2277307_+\|flotillin	unknown	unknown	gnl\|CDD\|225177
NZ_CP019605.1\|WP_077343002.1\|2264347_2264530_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379516
NZ_CP019605.1\|WP_077342992.1\|2260372_2261269_-\|mycothiol-conjugate-amidase-Mca	unknown	unknown	gnl\|CDD\|132487
NZ_CP019605.1\|WP_077343000.1\|2263652_2264330_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP019605.1\|WP_077343018.1\|2273637_2275092_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|224157
NZ_CP019605.1\|WP_077343016.1\|2272633_2273473_-\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|378959

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077343008.1\|2268477_2269464_+\|aldo/keto-reductase	gnl\|CDD\|381312	cd19086, AKR_AKR11C1, AKR11C family of aldo-keto reductase (AKR). Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.	6.14982e-101
NZ_CP019605.1\|WP_077342996.1\|2262319_2262736_-\|DUF2089-domain-containing-protein	gnl\|CDD\|378280	pfam09862, DUF2089, Protein of unknown function (DUF2089). This domain, found in various hypothetical prokaryotic proteins, has no known function. This domain is a zinc-ribbon.	1.48217e-43
NZ_CP019605.1\|WP_077343016.1\|2272633_2273473_-\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|378959	pfam12811, BaxI_1, Bax inhibitor 1 like. The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.	6.28949e-78
NZ_CP019605.1\|WP_093664751.1\|2266708_2268430_+\|hypothetical-protein	gnl\|CDD\|376789	pfam02457, DisA_N, DisA bacterial checkpoint controller nucleotide-binding. The DisA protein is a bacterial checkpoint protein that dimerizes into an octameric complex. The protein consists of three distinct domains. This domain is the first and is a globular, nucleotide-binding region; the next 146-289 residues constitute the DisA-linker family, pfam10635, that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), which thus forms a spine like-linker between domains 1 and 3. The C-terminal residues, of domain 3, are represented by family HHH, pfam00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis.	2.96907e-05
NZ_CP019605.1\|WP_077343014.1\|2271951_2272644_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240040	cd04684, Nudix_Hydrolase_25, Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.81452e-22
NZ_CP019605.1\|WP_077344301.1\|2259741_2260332_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	4.18009e-21
NZ_CP019605.1\|WP_077342994.1\|2261743_2262247_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	9.89538e-59
NZ_CP019605.1\|WP_077343022.1\|2275789_2277307_+\|flotillin	gnl\|CDD\|225177	COG2268, COG2268, Uncharacterized protein conserved in bacteria [Function unknown].	1.02042e-52
NZ_CP019605.1\|WP_077342990.1\|2257685_2259695_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP019605.1\|WP_077343012.1\|2270967_2271852_-\|neutral-zinc-metallopeptidase	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	1.92552e-88
NZ_CP019605.1\|WP_077343004.1\|2264586_2265255_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	5.28013e-124
NZ_CP019605.1\|WP_162274540.1\|2261329_2261731_+\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.03717e-09
NZ_CP019605.1\|WP_077343002.1\|2264347_2264530_+\|hypothetical-protein	gnl\|CDD\|379516	pfam14235, DUF4337, Domain of unknown function (DUF4337). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 201 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	0.00592442
NZ_CP019605.1\|WP_077342992.1\|2260372_2261269_-\|mycothiol-conjugate-amidase-Mca	gnl\|CDD\|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	1.6437e-151
NZ_CP019605.1\|WP_077343000.1\|2263652_2264330_+\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.52726e-120
NZ_CP019605.1\|WP_077343018.1\|2273637_2275092_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|224157	COG1236, YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis].	9.45109e-105

>NZ_CP019605.1|WP_077343004.1|2264586_2265255_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MEIDVLAWLNSRMNQTPQMVTEREALPGRDATILSPMPTHEVLGLPLDEVPTGCEVAYFALGCYWGVERLYWETDGVVNTAAGFMGGFTPNPTYRETCTGRTGHTETVRVVFDPARVSYDDLLRIFWENHDPTQVNRQGNDLGTQYRSAIFPTNDEQARAAERTRAEFQANLASEGFGSIATEIVPDQTFFYAEDEHQQYLHKNPHGYCPIHATGVKCGPRD
>NZ_CP019605.1|WP_077343002.1|2264347_2264530_+|hypothetical-protein
MSEPHTDPDRDPDVDAAPERPAGEITTGRRMLWLAGGGIGAYMVLRGVWGLATGEDQEQP
>NZ_CP019605.1|WP_077343000.1|2263652_2264330_+|uracil-DNA-glycosylase
MPKPLADLVSPDWADALAPVEGQIAAMGSFLRDEIADGHSYLPAGDQILRAFTRPLADVRVLILGQDPYPTVGHPVGLSFSVARDVRPLPGSLRNIYRELASDLGVEAPDHGDLTSWFEQGVLLLNRVLTVRPGAPASHRGKGWEEVTARAVEALARRGGPLVAILWGRDAQSATPMLGDVPIIASAHPSPLSARSGFYGSRPFSRANRHLEEQGAAPIDWQIPD
>NZ_CP019605.1|WP_077342998.1|2262737_2263532_-|hypothetical-protein
MTNVDLGPILDDLAAGRIDAKEASRRIEAAKKAAQPAGSGPAPEADTTHHGGPKAGGLARVSVTAVGRRVRIEGDPSVSTVIIDGPHVLRRVGTVLEVSSTGEFGPSFQGFSLIRPPRSLDDLRDIGLGKELAIRVNPALIVDVEVTTGGLRTVGVPRLGRIRVTAGGSTLQDVQEVEDLLSQAGGVTVEGPISIGRSRIRTESGSLTVHLTEGANVTIRGESRLGRISWPGGGENVDEFVVGNGSARLDVNVVMGMATIKTEA
>NZ_CP019605.1|WP_077342996.1|2262319_2262736_-|DUF2089-domain-containing-protein
MVKHLYHAPADCPVCGDELITTRKGCLKCGSELAGEFASCEFCALSEPDLQILRVFLGSRGNLREVEKHLQVSYPTARARLDAVLVKLGFDQAGERNAPEHAEQDGRDSDSATPESQILERVARGELSPEVAAQLLGD
>NZ_CP019605.1|WP_077342994.1|2261743_2262247_+|transcription-elongation-factor-GreA
MSETAADVVWLTQEAFEKLEAELNELKTVGREEVSARIASAREEGDLSENGGYHAAREEQGLMEGRIRQLEDLLRRAKVGQSQGAADEVAPGKLITVAYDGDDSDTDTFLLGSREVLGVDDSVDHQVYSPQSPLGSAIVGAKVGDEVRYEAPNGKELMVVVLKVETL
>NZ_CP019605.1|WP_162274540.1|2261329_2261731_+|DUF4307-domain-containing-protein
MTPEDQARLAQRYPKASPIDYVLGVGAGLATLAAIGLVIASGIEQSTPPVAGMVRSFEVTSPSEITAELVIQRENPSDAVECRLYAQAESYEKVAEDIIGIAPGTETLTSVDISLKTVKEATAITLDACRVVG
>NZ_CP019605.1|WP_077342992.1|2260372_2261269_-|mycothiol-conjugate-amidase-Mca
MTRADLPRLRLLHVHAHPDDESSKGAATTAKYVAEGVDVMVATCTGGERGSVLNPKLAGDPTVEANIAEIRRREMARAREILGVEQVWLGFVDSGLPEGDPPPPLPTGCFGTLDPRVAAGPLVRVIREFRPHVVTTYDEQGGYPHPDHIMCHRITVEAFNAAADPTAWPEHGPPWQAAKLYYHMSFHRRRFEQLERAMHEAGLECHFPARDEDPYSYGRLTTFVHCAEYFPVRDEALRAHATQIDPDGPWFAVPLAIQQAGWPTEDYQLVVSKVPTMIPEDDLFKGLRPEPLVPEFMI
>NZ_CP019605.1|WP_077344301.1|2259741_2260332_+|rhomboid-family-intramembrane-serine-protease
MTEPTARRATLRSALLVVGSLLALMWALEILDTVTLNALDAYGIEPRQASDLPNILWSPLLHFGWAHLISNSVPFLVLGVLVYVSGFGRWLVATLSSVIASGLAAWALAPIGSITAGASGVIFGWLTFLLVRGFFTKKPGQIGLAVLVFLLYGGVLLGVLPGAPGVSWQAHLGGAVGGVLAAWWMSRRGHRYGVGH
>NZ_CP019605.1|WP_077342990.1|2257685_2259695_-|thioredoxin-domain-containing-protein
MANRLRESSSDYLLQHAHQAVDWWEWSDEALAEAKAQDKPILLSVGYASCHWCHVMSHESFDDPTVAAFINEHFVPIKVDRQQHPDVDAVYMTATQAMNGGSGGWPMTAFLTPDGRPFFTGTYFPPEAQPGMPSFTQVLKAMADGWHSRRDKMTAAASYVAETLRVRDAAAPEGTPDLRAAIDQVESSFDLIHGGFGTAPKFPAPTLLDALLVKGDPRSLELAQRTLETMARGGIYDQVGGGFHRYSVDPGWVVPHFEKMLYDNALLLGTYVRGWRRTADHDSGLRALYERTAYGIVEWLEREMVNDGGGFVSALDADSCDIRGAVHEGIFYLWNPELLDDALGPELGEWAADVFHVTRGGTFEDGLSTLQLRGRPDYARLDEVSQKLLEERETRFRPATDELVVAAWNGWMITSLVAGSLIFNEKSWLELALRAAHHLLEVHSADGDLLRTSRRGQPGAALGSAEDFGAVAEAFSTLAGATGDAAWLRRAEALVDRAVELFGHPDGGFYDAVDTGLFDRPRSLTDNVTPSGTSALIAALRHVGLLAERPDLISRADEAARTTWATVGEAPRFAGAALGDLLIADEARRGLKPGVAVVVTDDPFDELARAAWRLAPAGSVILAARPGAEGFGTHLDGRSDRAVYVCRGTVCFDPVTDYNDLKTPLWTRV
>NZ_CP019605.1|WP_077343006.1|2265804_2266509_-|hypothetical-protein
MEMSPKPGSHAQLGRTFIAQQRVISVLSFFLPLFLITWSVLSGEGLRGSLSEYYYTPVRDIFVGVLCALSLFFWSYRGYHPHKAELRADRVVAKIASVSAALVALAPLKPRQVGECTLLQCVFGEQATDWVHNVAAVIFMTSLATFCLVLFPMTAIQRPDLGRRLVIYGICGTVIVAAMLLMVLWKFLPVDVYFALGHYKPIFMLETMALFAFSIAWLLRSRAVEDAALAQYDD
>NZ_CP019605.1|WP_093664751.1|2266708_2268430_+|hypothetical-protein
MNAELWDGQASYRRSLEQVANDALDAAGADLDVRAFVVGIPLDSDGGVVVEPARGHFDRSIVAQSTYLGTRRFNKLLREEAPDTDSPIYLAALEARTRRRAVADKLDYAARANGRIHFVGVSVRIGDHSVFPVLAIQGDQWRELPQLPDDAGDDFLTARSFQEAVLNTVLDVASRELDRQIPGSMVRIDPESVLRSAADLFVSAVVARTGQDQAFGALQAFDAVSAQPYEGRSGRGSILLAPQGDAGIQTVMELEHPVPIGRARSLRKVLELSVGGLHLLCDGREVYGLGKLDPDTPREHSFEARVSGNGSWELWDGDVPYLRVDNGVPGMPRELLNEDEFSVTVDRVFPDVSARNARFLWEIARGCTRQPHGTMLVVHPEAGSEAQRLLPQAYAITPARLGPEALSAATGIDGAVLVSPDGRCHAVGVILDGLATGTGDPSRGARFSSAIRYLAGAGRGAMVIIVSEDGKIDLLPKTKQRVRRATVQRAVDRLVAASAEGEDEDRFMRADRGVEAIEFYLNQEQCDVVNAAREAVEGRQWDLARVRRQYIPIAPDPAMDDSYFVDRAQDTPA
>NZ_CP019605.1|WP_077343008.1|2268477_2269464_+|aldo/keto-reductase
MEKRILGKTDRAVGVVGQGCWQFGGDWGDVGDGAAMGVLHAAADAGVTFFDTADVYGDGHSEELVGRFIKERGDSGLMVATKLGRRADPFVAETYTRENLRAWTERSLKLLGVDTIDLTQLHCPPTPVYSTDSVYDALDEMVDEGKLRNYGVSVETVDEAMTALERPGVATIQIILNVFRRKPLERVLPAAREAGVGIIARVPLASGLLTGKFSEDSSFAATDHRSYNRFGEAFDQGETFSGVPYELGVQAAREFAEVVPEGITPAQFALRWIIDQPGVSVVIPGASRAEQAEANAAAGSLPELTPAQLAALERIYDRRIREFVHDRW
>NZ_CP019605.1|WP_077343010.1|2269498_2270482_+|hypothetical-protein
MMFRWAAGLVCAALVASCAPGPVEPPQPTTASSRPTLSASASPSAEPSLLPDEDLPLAFVVGPALLPAADRVVARLHRAAGHLPVLRVDLTREQATLTALLPDNAVVSYRWRDDEITRVESDIQYFDQATFDPSDYPLDAAERMFDVADLQGVRGELVLQIVEYRAGQVAITITSRPETNTIFFRPDGSAVATLGVTSVADIAAGLQEVIGEATEAYAVGFDATRGYWADLPDDDAGVVLSRSRVGGVPTFETRRLELPTLEVFDPSSIRAAPLAQAIARAQDDADTSCAVQIDRSLGRSGPVAKIDCDGTVTYADLDGRDMTALIG
>NZ_CP019605.1|WP_077343012.1|2270967_2271852_-|neutral-zinc-metallopeptidase
MEFRSDARIDQSNVRYGGGGGRRGGRGMAVGGGLGGIIILVLMLLFGGGGIGDILGGGGAAQPQQQQPQENPNCQTGADIERDPECRWPAYVTAINDYWSQALEGYQPATTQLFSGQVGTACGTGSSEMGPFYCPGDNTVYIDTEFMGVLLNQLGAAGGYAAEAYIVAHEYGHHISNLTGQMREARAGGNDTGPESNAVRLELQADCYAGVWFKNAMNDPDGLIETVTQDDLNRIVDAARAVGDDHIQQQQGGRVVPESWTHGSSQMRQYWVAKGFQSGDPNVCDTFSTDDLGG
>NZ_CP019605.1|WP_077343014.1|2271951_2272644_+|NUDIX-domain-containing-protein
MRVVGVTHPLGAPVTSFDIDHGCHPRVTLFDHGYVPVRPLAAVKSADDIVFTWLVREVSVADQRPPERHTVYVSTPDETPRRYQRIGAYALVVSQRGILGTVNSRLTGAPGTWALPGGGVDPDESPADAVLREIYEETGQEVVLDRVLSLESEHWVGRSLAGRLEDFHALRVVYGAICKTPSDPVVHDVGGSTERADWVPARAWRKLHWTNSSRNLLAQYARKLSRPISP
>NZ_CP019605.1|WP_077343016.1|2272633_2273473_-|Bax-inhibitor-1/YccA-family-protein
MANPIIGRPDAFTRHGEAPGHQYQSYGAPQGYGAPQGYGAPQGFDPSLQQAPHQAPVGRMTLDDVIVKTAMTLGVVFLSAIATFRLLPMEFLLPALIGSGIVGLITVFFVAGRTKLPVGGVMFYALVEGVFVGAFSKYFEFLFPGIVVSAVLATFVTAASTLAAYKFFNIRVTPKFRKMVMIGTMSLLGVLLVNFVLALFGVNTGLREVGSGAGMLAILVSVIAVALAVANLIVDFDSVERGIAQGAPAQESWRAALGITVTMVWLYVEILRILSYFRD
>NZ_CP019605.1|WP_077343018.1|2273637_2275092_+|MBL-fold-metallo-hydrolase
MSTPRRATLTFLGASGTVTGSKYLLTIGDRRILVDAGMFQGEKMWRLKNREDFPVDPSTISDVLLTHAHTDHAAYLPALVKHGFRGAIYATEATIRLAEIVLRDSGRLQEQAVGDAVRGGYSKHEQPEALYTTDDVEATLPLFRSVEWNSDVEIDGVTARWVRSAHILGSASIHVTVGERSVLFSGDLGRHDHPILKDRETPPGADIVLCESTYGDREHPEPELPHEPFADAIRRTVAAGGQVVVPAFAIDRTETVLHALVQMRRAGRIPDVPVVVDGPMSLRALDVYKDESLGELDHDITIADFTDLNLSEARDGRDSKKLNRRTDPMIIISSSGMAEGGRVLYHLMRLLPDPKNTVVLTGYQAEGTRGRALEDGARNVKINGRHIRVKANIVRDHEFSVHGDASDLMDWLKALDKEPETVYVTHGEHHVAETFADRIENELDWAAVVPKYGEVVSIMGDGWDPEDLDVEVPEPQAAGTEPRE
>NZ_CP019605.1|WP_077343020.1|2275254_2275767_+|hypothetical-protein
MTTFLIIGAVGVVLVLVTLVVGDILDGVLHLDALDSDLFSISSLAAFIGAFGFGGAIGLGVLHNMVLAVIVGLIIGSLAAWGAVSLTKKLKSDGASFRSDSMIGHPGRVITAIPEGGYGEITISVAGHVRKITAKAEQAIDSGTEVWVSAILSPTAVEVTPTSGPHELIP
>NZ_CP019605.1|WP_077343022.1|2275789_2277307_+|flotillin
MPFSPVVTAIIGLVVLLLLVGLLIASRYKVAKPNEAFIITGRKGREVRNPETGLVSTDLSGQKVVMGGGVFVIPFIQRLHVLDLSSRRIMVTIRNAVSGQGIKLNVDGVAIVKVGGNEDSIRAAAQRFLSQQEEIETFTQETLAGSLRSIVGSLTVEQIIRDRAAFAQRVTDESESSLTGQGLVLDTFQIQDITDDGTYLSDLGRPESAKLGRMAAVAEAEARREAEQAQIAAEQEIAISKRELVLKQAEIQSETDAARATAAAAGPLAQADRDQAVLLEQEKVAVAQAALKERQLDTEVRRPADAERYRVETAAEAQRNAAIFEAEARKAASIANAEAEAEKARLTGVGEQSRRSALAEAEAIEGAKRGEAEKARRIAEAEAVRAEGEAKAAAVLAVGQAEAEAMDKRAEAFAHYNDAAVLQMLIEILPQMAEKVSAPLGNIDTLTVVSTEGASALPKTVANNMLQTLQMVKDTTGFDLGAVLDKVANKTAGDPTVIKEAPASE

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Crispr_ID: NZ_CP019605_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_6

2354283-2354375

Orphan

Consensus_repeat	Method
GGAGACGGAATGGGCCAGTTCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_6

>merge|NZ_CP019605|6|2354283-2354375|CRISPRCasFinder
GGAGACGGAATGGGCCAGTTCGGGACGCTACTGAGGGAGACGGAATGGGCCAGTTCGGGACGCTACTGAGGGAGACGGAATGGGCCAGTTCGG

>NZ_CP019605|6|5|2354283-2354375|CRISPRCasFinder
GGAGACGGAATGGGCCAGTTCGG	GACGCTACTGAGGGAGACGGAATGGGCCAGTTCGGGACGCTACTGAG
GGAGACGGAATGGGCCAGTTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077343147.1\|2350697_2351177_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NZ_CP019605.1\|WP_077343141.1\|2346264_2347755_+\|putative-Ig-domain-containing-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP019605.1\|WP_077343151.1\|2354473_2355232_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077344309.1\|2340325_2341798_+\|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl\|CDD\|224839
NZ_CP019605.1\|WP_077343157.1\|2357300_2357570_+\|FmdB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225210
NZ_CP019605.1\|WP_143028184.1\|2363711_2364818_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077343139.1\|2345168_2345927_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP019605.1\|WP_077343133.1\|2339329_2340169_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_CP019605.1\|WP_162274543.1\|2342041_2342773_+\|glycoside-hydrolase-family-95-protein	unknown	unknown	gnl\|CDD\|379625
NZ_CP019605.1\|WP_077343145.1\|2349256_2350675_+\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
NZ_CP019605.1\|WP_077343153.1\|2355301_2356594_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP019605.1\|WP_077343163.1\|2359291_2359639_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077343149.1\|2351228_2353928_-\|glucosidase	unknown	unknown	gnl\|CDD\|367389
NZ_CP019605.1\|WP_077343165.1\|2359631_2361008_-\|UTP--glucose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|366766
NZ_CP019605.1\|WP_077343137.1\|2342811_2345160_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NZ_CP019605.1\|WP_077343161.1\|2358432_2358801_+\|MscL-family-protein	unknown	unknown	gnl\|CDD\|376605
NZ_CP019605.1\|WP_077343159.1\|2357675_2358293_+\|flagella-basal-body-P-ring-formation-protein-FlgA	unknown	unknown	gnl\|CDD\|212159
NZ_CP019605.1\|WP_077343155.1\|2356611_2357187_+\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|274270
NZ_CP019605.1\|WP_162274544.1\|2348029_2349124_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP019605.1\|WP_077343167.1\|2361120_2363715_-\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|259871

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077343147.1\|2350697_2351177_+\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	1.63269e-40
NZ_CP019605.1\|WP_077343141.1\|2346264_2347755_+\|putative-Ig-domain-containing-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	3.48838e-06
NZ_CP019605.1\|WP_077344309.1\|2340325_2341798_+\|phospholipid-carrier-dependent-glycosyltransferase	gnl\|CDD\|224839	COG1928, PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].	6.72663e-23
NZ_CP019605.1\|WP_077343157.1\|2357300_2357570_+\|FmdB-family-transcriptional-regulator	gnl\|CDD\|225210	COG2331, COG2331, Uncharacterized protein conserved in bacteria [Function unknown].	5.76142e-28
NZ_CP019605.1\|WP_077343139.1\|2345168_2345927_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	3.00633e-85
NZ_CP019605.1\|WP_077343133.1\|2339329_2340169_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	2.4632e-104
NZ_CP019605.1\|WP_162274543.1\|2342041_2342773_+\|glycoside-hydrolase-family-95-protein	gnl\|CDD\|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	2.96635e-42
NZ_CP019605.1\|WP_077343145.1\|2349256_2350675_+\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	4.0869e-99
NZ_CP019605.1\|WP_077343153.1\|2355301_2356594_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	4.99929e-91
NZ_CP019605.1\|WP_077343149.1\|2351228_2353928_-\|glucosidase	gnl\|CDD\|367389	pfam03200, Glyco_hydro_63, Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.	1.58182e-10
NZ_CP019605.1\|WP_077343165.1\|2359631_2361008_-\|UTP--glucose-1-phosphate-uridylyltransferase	gnl\|CDD\|366766	pfam01704, UDPGP, UTP--glucose-1-phosphate uridylyltransferase. This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyzes the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete.	1.05241e-150
NZ_CP019605.1\|WP_077343137.1\|2342811_2345160_+\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	2.57417e-08
NZ_CP019605.1\|WP_077343161.1\|2358432_2358801_+\|MscL-family-protein	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	4.03615e-32
NZ_CP019605.1\|WP_077343159.1\|2357675_2358293_+\|flagella-basal-body-P-ring-formation-protein-FlgA	gnl\|CDD\|212159	cd11614, SAF_CpaB_FlgA_like, SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB. FlgA is a putative periplasmic chaperone that assists in the formation of the flagellar P ring; CpaB is a protein invoved in the assembly of the flp pili, which are bacterial virulence factors mediating non-specific adherence to surfaces; these proteins appear to contain a single SAF domain. This intermediate family also contains the SAF domains of sialic acid synthetases and type III antifreeze proteins, which also share the same extensive core structure.	4.30244e-08
NZ_CP019605.1\|WP_077343155.1\|2356611_2357187_+\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	2.52857e-38
NZ_CP019605.1\|WP_162274544.1\|2348029_2349124_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	6.04284e-11
NZ_CP019605.1\|WP_077343167.1\|2361120_2363715_-\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|259871	cd04208, CuRO_2_CuNIR, Cupredoxin domain 2 of Copper-containing nitrite reductase. Copper-containing nitrite reductase (CuNIR), which catalyzes the reduction of NO2- to NO, is the key enzyme in the denitrification process in denitrifying bacteria. CuNIR contains at least one type 1 copper center and a type 2 copper center in the protein. The type 2 copper center of a copper nitrite reductase is the active site of the enzyme. A histidine, bound to the Type 2 Cu center, is responsible for binding and reducing nitrite. A Cys-His bridge plays an important role in facilitating rapid electron transfer from the type 1 center to the type 2 center. A reduced type I blue copper protein (pseudoazurin) was found to be a specific electron transfer donor for the copper-containing NIR in bacteria Alcaligenes faecalis.	2.41371e-53

>NZ_CP019605.1|WP_077343149.1|2351228_2353928_-|glucosidase
MVSRYSPGQTAEHERLAAATDDHAPWRLWGPYVSGRQWGTVREDYSADGNAWDFFPFDHSHRRAYRWGEDGIAGICDRYGFLNLAPAFWNGDDDRLKERLFGLTNAQGNHGEDTKELWWHVDATPTHSYGEYLYRYPQRAFPYRQLVDEGSAQPKEAREYKLVDTGVLDEDRFFDITVVHAKDSPDDIVVEFHVVNHGPEAAPIDVLGQWWFRNTWSWGRDERRPVITRGRAAGRDCLTAKHEWLGTYHLVAEDGPAGAPRFLLCDNETNAERVFGSDSGTPQPAHPKDAIDDAVVHGDESGLADDKGTKAAVWWHLDAVQPGEEVVLRLRMMGDASASRIRNPFAAACEVVADRKADADAFYGVVIPEKASAEDTFIARRAFAGLLWCKQLYRYSVRDWLEGDPNEPAPPAERLEPEPDGRNTYWRHLALADIISMPDEWEYPWFASWDLAFHCVALARIDPWFAKEQLVLMCREWCMHPSGQLAAYEWKFSDVNPPVLAWAARVVFFADGAWDRAFLVRVFTKLLLNFGWWVNRKDENGSGLFEGGFLGLDNVTVFDRSAPLPEGQILEQSDATSWMAFYCLSMLKIAVELARDDDGWGDIATKFFEHFLEIAEAMDAFGNPAAALWDEEDGFYYDVLVDNGVPAPVRVRSLVGLLPLLGVMNLPDDISDQLPDLKRHTAWLRDRRPEVTEPIMQRHDGVTTLSVVTRDRLRRLIQRILDEGEFLSPHGIRSLSAAYRSEITVELPGHGKLPIDYQPAESRDYLFGGNSNWRGPVWFPINTLLVHALATYGRGIAKDETFEFPTGSGKWLTLEAITHELRQRLISLFRVGPDGRRPSDPIHMPTGPLWQAHPTFSEYFNGDTGAGLGAAHQTGWTAMVADLICAEDGDDPVRGDAMS
>NZ_CP019605.1|WP_077343147.1|2350697_2351177_+|flavin-reductase-family-protein
MDELQLTFRDAMARVPAPVTVITTMVDGVPIGTTVSAFASLSIAPPMAFLALDNRGGMIGRVRDAGRIGINILAAGQEEIAIRFARRDLPDRFAGLAWHDDHGLPRIDGAVAWLRCEQLQLLPGGDHTVILAHVDDAATAGDHSLGYHLRTFRDVGPAT
>NZ_CP019605.1|WP_077343145.1|2349256_2350675_+|nitrate-reductase
MWKLHNNGVLLPDAVVTPTERLTWGRTVGLGAQHVVAMFGATFVFPLLMGLNPQLAVMMSGVATLLFLFVVKHRVPSYLGSSASFVGVATAVYTAGGNPATLTGALFVVGLLLFMAGLIIHFAGARVIHRALPPVVTGAVVMLIGFNLAPVVASEYWPVDPWLAFLVMLIVVGLSIGLRGFWGRIAIFLSLVVGYVLSWAADVVMGPLQTADGARPRVDWSNVAAADWIGFPPLTDLANWTYGATDNVVGFHLPQFSLGAIIVAMPVVIALIAENTGHVKAVAEMTKDDLDPLMGRAIAADGAGSMVATLVGAGPTTTYAENIGVMAASRVYSTAAYVVAAVVAILFGFSPKFGAVISATPSAVLGGITVVLYGMIGLLGAKIWKENNVDFGNPLNLIPASAGIIIGIGNVSVPLGGDFELGGIALGTIVTIGVYHLARIIAPRTMREQADGASIIYDAPGIYTDEDATPRL
>NZ_CP019605.1|WP_162274544.1|2348029_2349124_-|FAD-binding-oxidoreductase
MAHDVVVLGATVAGLTASRRLAAEGYDVVVLDPNLELRSAAIGHGVAAIGHASTVANMAHAYGLEAAREHVRRNIAALQEIRTTLPDHDTHTLRDQSLPGGDERETQEIAALYRSQGTQASVAGGPRDATLITEATCVDPAEYASALRTAAVGEGVQVVHGVTVTHLKRKEGVTRVGFRNNLAWARELGSITGAAVIDTLGVSPWGRVARVGPAQWVPVVRCVPGVPVTDVRLHATGPAWMVRPTTEGALVLGQKTSLSAIDESTIELEQWAAEALGAEWMETGRLAIDPSDHGRPVVGASAIPGGFYARGNGRGELMNGTASGYYLATLLLGDDAAPGNALPPLSRMRAYGSRLRRASHRPAE
>NZ_CP019605.1|WP_077343141.1|2346264_2347755_+|putative-Ig-domain-containing-protein
MLQCAGRGRRARLLQRAFLEPSDATYVEVATGQFESTNTNPKTVVFDEPVTTRFVKLTSLSAVGGQAWAHIAELQVRGAAAEAPALLDDPAVEPRVWVSPSSVPVGGSVLVTGGGFAPGEVTVEAGGESVTAVADGFGFVATELTLPAAGQVTVTVSQGDLSASASAEVTAAPATAPVIADLADVSVEVGETVSVQASATGTAPIVFSASGLPAGVAIDPASGVISGEPEAAGSSSVTVTATNEAGSDSTSFTMTVAEAPVVDTTAPAIAAVGPVTGKQGTALSVTFEASDESLPLTYSATGLPAGVSINPSTGVISGTPTGHGVSTATVTVTDAAGNTASTTVRFTIAATAYEFVPTAPYTKPGVHFVNGRQWLTTCEPYSQTQRCRTDIWASVVKKTDTGFVIERGWAFNNLTYLPYMTRAQWASNPLGTPGYFLGTDNAQWRTECDTAATGANACRTYRLTTVYAAHAKPGGGYTFSQSNEWVFNNMVMFRPW
>NZ_CP019605.1|WP_077343139.1|2345168_2345927_+|ABC-transporter-ATP-binding-protein
MSTPTALLSATGVRKSFPIDGSNIEVLHGVDLHITEGEFVAVMGPSGSGKSTLLYAVSGMDPVDAGDVHLAGTELTTLDGDGLADARRELMGFVFQQPTLLKDLPLLDNIVLTSALDKVGTPAERRARAEELMTRAGIWELRDRMTSQVSGGQLQRAGICRALMRRPRIIFGDEPTGALNSTAAGEIMDLLSDLNAEGTTLLVVTHDVRVAARAHRVVFMVDGQVTDELLLDADDEETRVDLVTRRVRELRI
>NZ_CP019605.1|WP_077343137.1|2342811_2345160_+|ABC-transporter-permease
MRRSRTTAVILVAFVALSAMLASAAGTLMITANGATASLMRQARTPHLLQMHAGQVDHDRLRDFAENNPHVEQWIAAPMLNVDGAAIRVTGDDGTDTNLAAGLQDNSFVTQNTKFDFLLDTDGQVIDPEPGTVWLPLFYQQSLDLGVNQTVTVSGPGEPITLRVAGFLRDSQMNASYASSKRLLVSQPDFDALALALGEAGSIEYLIEFRLDNPADVSSFDTQYREAGLEANGPTITWTLFALINSLSSGITAAVVATVTLLLVAIAFLCVRFTLMTTIEQDYREIGVLKALGVRHRDLSRMYSRRYLVMAAAGAGIGFLASLGLSRVLLRDIELYMGPAGRTVQSLLTSLVLSAVIVLVIALAVRRTLRRLAKVSPVQAIRTGSASQKPVRRAPRWLSIGAGRFNTNDLLGLGDVLRRPGLYVLPLVIYTLAAFILVVPQNLHTTVTRPDFITYMGAGVSDMRIDVPQSAGLDRVREVDQQLAIDPQVSRHTLLTTASYTSTGADGGRVTVKVESGDLAAFPVTYLSGRAPESDADLGLSALQAAALGASLGSQVTLTPVRAANGAPQQVVLTVTGIYQDLTNGGQTAKMLRAHTSADVMWNILFADFIEGTDQTATIAAYTQAHPDVKVSSVSVYVNATLGGTISALQGVAAVSFVVGVLVAVLITALFMRMLMVRDGFSIAAMKALGFRNSDVHRQYVVRSLAVLVVGIVLGVVLANTLGGTLAGLMLSSIGLSQLHLVANPWLAYLASPLALVAAVVIATLVSTRPSDKYSISQTIKE
>NZ_CP019605.1|WP_162274543.1|2342041_2342773_+|glycoside-hydrolase-family-95-protein
MSRITKSLVAGLSAALIASTAVVTGLMAPQAAAAPQTEQDALVLRYTAPAPLNRWQEQALPIGNGALGASIFGQVTNDEVFLNEKTLWTGGPGVDGYRYGNYPESEIEQRRANLEQVRDTINENGSMTAGAVANLLGQPKLGYGSYQSFGRLQFAFDNGAGTATGYERSLDIDNSIAKVTYTVGQTTFTREYFASYPDNVIVSGALRPMPGSARGAAGGQIRTPPMWVVGRLRSLRVAAQEAK
>NZ_CP019605.1|WP_077344309.1|2340325_2341798_+|phospholipid-carrier-dependent-glycosyltransferase
MAFALRVWNVGYPAKILFDETYYAKEAWGILHSGYERKWGEDANAQIAEGDLSGFLDAPSYVVHPPLGKMLIALGEWGFGMTPFGWRISAVVFGTLLVFFTIRLARRLSRSTLVGAMAGLILTFDGLAFVMSRLALLDVFQATFAVAAVSALVADRDWFRHKLADHLRSIGEPDLGGRFGPLLLWRPWRVLAGVLFGASCAVKWNSIFMVAAFGILVVFWDLGARRLAGAGRKQWWSLAIDAPAAFVQLVVVAVPVYIASWFRWLTTDGGYYRQWGVENPDDPVVQRVGAALGALWHYHHEAYNFHTGEKMMQEATHPYEAHPAGWLFMIRPIGIEAVNGIEPGTDGCDAVGTTCLRIISAMGTPLLWWFAAAAIAAAVVWWILGRDWRFGVPLLGIASTYLPWFRYADRPLFFFYAIMIIPFSATVLAMALGKILGPVGHPRRRLRAMAVGIVLALIILNFAFIYPILTADLLTKPAWMLRMWLGNAWI
>NZ_CP019605.1|WP_077343133.1|2339329_2340169_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MHCGALILAGTPIGSSTDASTTLRETLSSADVIAAEDTRKFLTLTRRLGVETTAKVVSYFEGNEASRTPELVRAIDEGQRVVLVTDAGMPSVSDPGYRLVVACVEAGLRVTAVPGPSAVLTALAVSGLPVDRFCFEGFLPRKSGERRRRLAALAREERTMVFFEAPHRLADFLTDAAAELGADRRGAVCRELTKPYEEVVRDGLADLAAWAADGVRGEVTVVVEGAPPSSTSPDEALALVRDAIAGGAKLSAAVADVAAVTGANRKQLYAAALADKEKK
>NZ_CP019605.1|WP_077343151.1|2354473_2355232_-|hypothetical-protein
MLAGILIAIVVVAGIAVALPWVAAQKPADVELESDPAERFADSMRIIRSDITDYVAEQDAAEVSTPLTRRAELNELRLIAKQAAKRRRTTVLLLLTALVVVTVLSALSITPWWSLAIPGTPLIAFLAVARFTVVAMHRSLDARAAAVRAGYDDAEDTTTIDLSAHAETEEFEISVDLTMPTTMGALWDPIPITPATYVSQPLLPRTVRTIDLSAPVASAPLVPTADHPDAVLDDEETLGAPITELRPRAVGE
>NZ_CP019605.1|WP_077343153.1|2355301_2356594_-|molybdopterin-molybdotransferase-MoeA
MAWFGRKKQDDDVVEEEIIEEPRLPEPPAADAQGLRSVADHTAYLLELVEPLKPFGMSLLEAWDQVMCEDIDSMINVPPASTAKVAGYAVRASDLLDDEGHLAPPLAIVDADVDHLPADAAVVVGAGDVLPRGANAVLPSSFAAVEENHVRLIEKVSAGEYLRAAGEHLRQGTRLLSEGDVLGERAIGLLASAGVDKVLVRPRPRVVVVSSGEHLVEPGAEIRHGDVADTNSFMIAAAARAIGATVFRVAVHSNDPDAIREAITDQLIRADLVISTTGGRREDYETVASVMRDLGLVDSVDVLMTPGRTQTFGLIGDERVPMLMLPGNPVSAYVSFHAFARPLIRRLMGARTEHRAVRAIASGTLRSLRGQMHLLRGRVWSEGSVRHVEQVSAPHALTELARSNALIVLDDGIETVRPGEAVKVWLIEEE
>NZ_CP019605.1|WP_077343155.1|2356611_2357187_+|5-formyltetrahydrofolate-cyclo-ligase
MPSDAQKDSLRSRVSAARSRVTDGEWSAVSRAMTRSALNFADARPTATVALYASRAAEPETGELITELARRGWRVLLPVIRRAVDWAEFGGWDEMAVGWGGIPQPTGPRLGAPALASASLIFVPCTAIGRDFSRLGTGGGWYDRALLHRTADAAVIALVREADVFDTVPTEPHDVAVDGYITEAGATFKDS
>NZ_CP019605.1|WP_077343157.1|2357300_2357570_+|FmdB-family-transcriptional-regulator
MPTYQYRCTECGTDLEVVQKFTDDALTVCPDCDGELRKVFNAVGVVFKGSGFYATDSRKSKTASTKSASPAAEKAAPKTEAPKVEAKSA
>NZ_CP019605.1|WP_077343159.1|2357675_2358293_+|flagella-basal-body-P-ring-formation-protein-FlgA
MRPLRSAATFVSWHRRLIGSVLIAASVVTIAQWVARPAPETRAVVTLAVDLTAGQLISAEHVEMRQIPDSALPLGAFSSDDGVVGRAVAVGLSRGTVLQDGLLASGQEVSAGRAAVPITLPDARLLTLLRPGDAVTLVAVGMDSADVITDLARIAALPTESQPGVLSVGSGGAGGLVLVDVPVDQAPRVAAMGQTGQLSVILGGG
>NZ_CP019605.1|WP_077343161.1|2358432_2358801_+|MscL-family-protein
MKGFKEFLMRGNLIELAVAFVMAAAFAKVVETFTAMFMDLLGKLGGTPDFSSYNPGGISVGAFLTALVAFFIVAAIIYFGVVLPYTKAKERFDKSVEEAPALTKSEQLLEEIRDSLRGRNAL
>NZ_CP019605.1|WP_077343163.1|2359291_2359639_-|hypothetical-protein
MSDDAALAEALGQALTGERLQLTSPALLEGQLAELGYDRRRLGEIRARCQEVRAAWPFDVGPDTRRAIGFARFDAALAEARSALGLDGLRPTMPTVRPLDRDDRRLTEDRPPHWG
>NZ_CP019605.1|WP_077343165.1|2359631_2361008_-|UTP--glucose-1-phosphate-uridylyltransferase
MSKEGLAAARAKMEEAGVSTPAIEVFTRFYELLESGETGIIREDSIEPLLDPPMLADVDITDLQAREAIQKTVIIKLNGGLGTSMGLDKAKTLLEVRDGNNFLDLLAQQVLAARERYDARLPLLLMNSFRTEADTLDYLSKYPELPVGDLPLSFMQNQEPKLRADDLTPVEWPADPTLEWCPPGHGDLYPALEGSGVLDALLEAGFRYACVSNGDNLGAAPNATIAGWFAQSGAPYAAELCRRTINDKKGGHLAVRKSDGQLILRDTAQTASEEMEFFTDEHRHPFFHTNNLWFDLQVLRETLTERGSVLGLPLIRNEKTVDPSDSSSTPVIQVESAMGAAIEVFEGATAICVGRDRFLPVKTTNELLLLRSDVYELNDEGRLIARTSSTPEIDLDSRYYKKVDKFEQRIPVAPSLRRATSLKVTGDWTFGPGVKVVGDVTLPDEGEGQQVPAGTTLE
>NZ_CP019605.1|WP_077343167.1|2361120_2363715_-|multicopper-oxidase-domain-containing-protein
MRRGRSLRDYALVFWLVAAGVVAIAHQWVPEATWLMVHLVALGALTHAAMVWSAHFTAALLRTRHDDDARNRHNRRLGVLGLGSLLVLVGVPIAQWWLVLVGALLVTAAVVWHATLLLADLRRALPGRFRICVRYYVAAAACLPVGAGFGTALAWGLDSRWHANLLVAHTMTMLLGWIGLTVVGTLVTFWPTVLRTRMDDRAEALAKRALPLLIGALAVVIAGSVAGWRPAAALGIAAYAAAIVYWGRSLVAPLRKSPPKEFASASIGAAGVWAVVGLVATAVHVLRADDLELASGYPLIASVWVVGFGLQLLTGALSYLLPSVLGGGPRVVRAGARHFDRWATARLVVINAGLLLWLLPLPGWIRVTVSSTVLLALLVFVPLLIAGIRASVAERRRAAAGEPAAPHERPNAMTGSGLMAGVAALALAVTVGFGIDPGAAGIAAPAPPTSAVAPSGETVRVEVSAVGMSYEPNRIEVDQGDRVVVVLTNEDPTNVHDLAVGASRTPRLAHGETAELDLGVVGESLEGWCTVVGHRQMGMTLDVVVRGAGEAPPDDAPAAHEGHQPAHGDPSARLSSVVDPVAPALPNGTVHRHEFRVTEVPLEVAPGLWQRRWTFNGASVGPTLRGKVGDRFEITLINDGTMGHSIDFHAGAVAPDVPMRTIAPGESLVYTFTAERAGIWMYHCSTMPMSAHIAAGMHGAVIIEPAEGLPEVDREYVLVQSEVFADDAASAEDASDVDADAVLAEQPDRVVFNGVANQYDQQPFAARVGERVRFWVLDAGPNRPTSFHIVGGQFDTVYREGGYVLRDGVDPFGNSGGGSQALALQPAEGGFVELTFPEAGHYPVVSHIMVDAERGAHGIVRVEE
>NZ_CP019605.1|WP_143028184.1|2363711_2364818_-|hypothetical-protein
MTTTTPPARSTTTERAGDTARRLRTGLVLLAGVSLLTGLNAGLLRLGVWAPVASTRLGDLHGPVMVLGFMGSLIALERAQALRNPLAYLAPALLAAGSVALIAGAPLLLGKLLLLDGALAFTAVAIALWRRAPLGLVAAQAVGTAFAALAAGLWLVTDLAVILPLLAAFLVIMIASERAELAQLTMGRRAVPALLAATVVVSASAVATLVAPDWGARALGLGCLLVAVWLIRDDVGRRMIRSTGLRRFNAAALLLGNLWLGVAGVVWAVGGQPSASGAYDAVIHGVFLGFGMSMIMAHAPIIFPTVLGRPLPYRPAMWGPLALLHLGMATRLTGGLAAIAPLYRLGGVLTVLSVLAFAITVIYSVVKR

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Crispr_ID: NZ_CP019605_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_7

2450765-2450877

Orphan

Consensus_repeat	Method
GAGTAGGGAGCGAGGAACGAGCGACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_7

>merge|NZ_CP019605|7|2450765-2450877|CRISPRCasFinder
GAGTAGGGAGCGAGGAACGAGCGACCGGCCCTCCCGTCTCCCCGAGTACGGAGCGAGGAAAGAGCGACCGGCCCTCCCGTCTCCCCGAGTAGGGAGCGAGGAACGAGCGACCG

>NZ_CP019605|7|6|2450765-2450877|CRISPRCasFinder
GAGTAGGGAGCGAGGAACGAGCGACCG	GCCCTCCCGTCTCCCCGAGTACGGAGCGAGGAAAGAGCGACCGGCCCTCCCGTCTCCCC
GAGTAGGGAGCGAGGAACGAGCGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077343329.1\|2454385_2456155_-\|L-fucose-isomerase	unknown	unknown	gnl\|CDD\|182885
NZ_CP019605.1\|WP_077343334.1\|2458518_2460036_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP019605.1\|WP_077343301.1\|2441564_2442938_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|273568
NZ_CP019605.1\|WP_077344315.1\|2457517_2458477_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NZ_CP019605.1\|WP_077343320.1\|2449665_2450715_+\|lipoate--protein-ligase-family-protein	unknown	unknown	gnl\|CDD\|223173
NZ_CP019605.1\|WP_077343317.1\|2448679_2449573_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|225176
NZ_CP019605.1\|WP_077343340.1\|2463746_2463971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225097
NZ_CP019605.1\|WP_077343308.1\|2445580_2446309_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP019605.1\|WP_077343327.1\|2452791_2454207_-\|rhamnulokinase	unknown	unknown	gnl\|CDD\|198349
NZ_CP019605.1\|WP_077343299.1\|2439083_2441540_-\|alpha-ketoacid-dehydrogenase-subunit-alpha/beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP019605.1\|WP_077343323.1\|2451361_2451799_-\|RbsD-or-FucU-transport	unknown	unknown	gnl\|CDD\|377444
NZ_CP019605.1\|WP_077343331.1\|2456365_2457448_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380660
NZ_CP019605.1\|WP_077343297.1\|2437721_2439062_-\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|197753
NZ_CP019605.1\|WP_093665149.1\|2460691_2461852_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP019605.1\|WP_077343311.1\|2446310_2447729_+\|tryptophan-rich-sensory-protein	unknown	unknown	gnl\|CDD\|187556
NZ_CP019605.1\|WP_077343325.1\|2451812_2452799_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP019605.1\|WP_077342173.1\|2461848_2462361_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP019605.1\|WP_077343305.1\|2444332_2445085_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP019605.1\|WP_077343303.1\|2442952_2444317_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP019605.1\|WP_077343314.1\|2447915_2448587_+\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|183656

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077343329.1\|2454385_2456155_-\|L-fucose-isomerase	gnl\|CDD\|182885	PRK10991, fucI, L-fucose isomerase; Provisional.	0
NZ_CP019605.1\|WP_077343334.1\|2458518_2460036_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP019605.1\|WP_077343301.1\|2441564_2442938_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|273568	TIGR01350, Dihydrolipoyl_dehydrogenase, dihydrolipoamide dehydrogenase. This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.	8.97221e-159
NZ_CP019605.1\|WP_077344315.1\|2457517_2458477_-\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	5.34266e-75
NZ_CP019605.1\|WP_077343320.1\|2449665_2450715_+\|lipoate--protein-ligase-family-protein	gnl\|CDD\|223173	COG0095, LplA, Lipoate-protein ligase A [Coenzyme metabolism].	5.94849e-61
NZ_CP019605.1\|WP_077343317.1\|2448679_2449573_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	4.44644e-14
NZ_CP019605.1\|WP_077343340.1\|2463746_2463971_-\|hypothetical-protein	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	0.00863114
NZ_CP019605.1\|WP_077343308.1\|2445580_2446309_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	9.58843e-07
NZ_CP019605.1\|WP_077343327.1\|2452791_2454207_-\|rhamnulokinase	gnl\|CDD\|198349	cd07771, FGGY_RhuK, L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is predominantly composed of bacterial L-rhamnulose kinases (RhuK, also known as rhamnulokinase; EC 2.7.1.5), which are encoded by the rhaB gene and catalyze the ATP-dependent phosphorylation of L-rhamnulose to produce L-rhamnulose-1-phosphate and ADP. Some uncharacterized homologous sequences are also included in this subfamily. The prototypical member of this subfamily is Escherichia coli RhuK, which exists as a monomer composed of two large domains. The ATP binding site is located in the cleft between the two domains. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of divalent Mg2+ or Mn2+ is required for catalysis. Although an intramolecular disulfide bridge is present in Rhuk, disulfide formation is not important to the regulation of RhuK enzymatic activity. Members of this subfamily belong to the FGGY family of carbohydrate kinases.	0
NZ_CP019605.1\|WP_077343299.1\|2439083_2441540_-\|alpha-ketoacid-dehydrogenase-subunit-alpha/beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.13346e-102
NZ_CP019605.1\|WP_077343323.1\|2451361_2451799_-\|RbsD-or-FucU-transport	gnl\|CDD\|377444	pfam05025, RbsD_FucU, RbsD / FucU transport protein family. The Escherichia coli high-affinity ribose-transport system consists of six proteins encoded by the rbs operon (rbsD, rbsA, rbsC, rbsB, rbsK and rbsR). Of the six components, RbsD is the only one whose function is unknown although it is thought that it somehow plays a critical role in PtsG-mediated ribose transport. This family also includes FucU a protein from the fucose biosynthesis operon that is presumably also involved in fucose transport by similarity to RbsD.	3.1252e-37
NZ_CP019605.1\|WP_077343331.1\|2456365_2457448_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380660	cd20005, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	1.44339e-115
NZ_CP019605.1\|WP_077343297.1\|2437721_2439062_-\|histidinol-phosphatase	gnl\|CDD\|197753	smart00481, POLIIIAc, DNA polymerase alpha chain like domain. DNA polymerase alpha chain like domain, incl. family of hypothetical proteins.	5.83997e-05
NZ_CP019605.1\|WP_093665149.1\|2460691_2461852_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	7.01521e-05
NZ_CP019605.1\|WP_077343311.1\|2446310_2447729_+\|tryptophan-rich-sensory-protein	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.80319e-113
NZ_CP019605.1\|WP_077343325.1\|2451812_2452799_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.38305e-76
NZ_CP019605.1\|WP_077342173.1\|2461848_2462361_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.7767e-42
NZ_CP019605.1\|WP_077343305.1\|2444332_2445085_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.27112e-82
NZ_CP019605.1\|WP_077343303.1\|2442952_2444317_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	1.82185e-121
NZ_CP019605.1\|WP_077343314.1\|2447915_2448587_+\|fructose-6-phosphate-aldolase	gnl\|CDD\|183656	PRK12656, PRK12656, fructose-6-phosphate aldolase; Reviewed.	2.26813e-101

>NZ_CP019605.1|WP_077343320.1|2449665_2450715_+|lipoate--protein-ligase-family-protein
MRGEYKVPGGKLVAVDVQTEDGRLTEAFISGDFFLEPDEALDDINGALLGMPENASVADLAAAITARLSPETRMIGFNAEAVGIAVRRALGHATDWSDHTFDVIGPVTMDPRMHVALDEVIAGELARGEINPSLRIWDWDQPLVVIGSFQSYRNEIDDEGRAKHGINVVRRITGGGAMFMEPGNCVTYSLVVPASLVEGLSFERSYEFLDQWVMGALAELGVNARYVPLNDIASDEGKIAGAAQRRVTGGVVVHHVTMAYDIDADKMLEVLRIGREKLSDKGTKSANKRVDPLRSQTQLPRDEILEAFLTHFEGRYETARRDYTDDELAKAKHLVETKFSSDEWTKRIP
>NZ_CP019605.1|WP_077343317.1|2448679_2449573_-|alpha/beta-fold-hydrolase
MRRLTTALASLSGGAALGVLGVAGYTAWSLNGPRRPWPDYAFTPFEVRADSEDVRFATADGVGLAGWWLDQPGSGTVVICAHGHRGTKSDMLGIGSGLWRAGHTVLLFDFRGNGDSDDGPQSLSHHEQADLRAAIDLASSRRPDARIVVVGFSMGASTAILEGATDPRVAAFVLDSPFSTMGEVVAANYRRYRLPSEPIVPLADLINRLRYGYSYAQVRPLDAAPALAPRPVLLIHGTDDRVIPYDHAVQLARAAGPNCELVTFEGVDHCGAYFEDRQGYIDRVARFLDAAVGRARR
>NZ_CP019605.1|WP_077343314.1|2447915_2448587_+|fructose-6-phosphate-aldolase
MDILFDTANLDDIERLTPIYPVTGVTTNPSILKAEGKIDFYPHMRRIREIIGPNRTLHVQVLAKTAQGMIDDAHRLLDKIDADVYPKIPTTEAGIAAMRHLKEEGVKVTATAIYSKTQGFLAIATGVDYLAPYYNRMQSLDIDTRGTIEVLAGFIKRFDAPGKIMAASFKNVAQVSHALESGADAVTLSPKLLRAALSAPDIDRAVDDFIKDWKAIYGTTELP
>NZ_CP019605.1|WP_077343311.1|2446310_2447729_+|tryptophan-rich-sensory-protein
MTQRTALVTGASGYVGAQLVPALLDAGWHVRVLARTPSKLQGDWRDLVEVAQGDATDPDDVRAALDGVQVAYYLLHSMDGQGDYRERDRRMAHTFAEAAVAQGVGRLVYLSGLHPEGPLSTHLASRVEVGDILLASGVPTAVLQAGVVLGDGSASFDMLRHLTERLPVAIGPKWLRNRIQPIAIDDVVHYLVRAAELDPQVNRTIDIGMDEILTYRDMMRRYARATGLLPRIIGTVPVLTPWLASHWVGVVTPVDSGIAKPLVGSLIHEAVKSEDDAATLLGDPPGGVLGFDAAVRRATDGVDPHRWSRTLFKVGAGVAATAVAGSLLTAPDSAWYRRLRKPVFQPPPVAFPVVWTALYALITVAGTATIADLHEDDRADEAQGFGRALAANLVLNAAWSGLFFRAKNPPLATAGAAVLAASSADLSRRAASAGEGKAAAFGAYAAWCTFATLLSAAVARLNPSSRSPRLPK
>NZ_CP019605.1|WP_077343308.1|2445580_2446309_+|CPBP-family-intramembrane-metalloprotease
MPIPTVVREVRAFLSASLVRPVERQRDETPESRRRRRIVVGVTLVIGAVALGLALAVRPGDPLFYAATLGVAAIWTVGALVSGPLHLGEGHTRDGGRSRGVVQGILLGLGLMGIFLAGALVVEQIPLLRGPVLDLLDHARFGSLWVVALVTVINGIAEELFFRGAVYASLDSRFNGIGSTLLYAASTLFSGVPLLTFAALCLGLLTAAQRRVTGGVLGPIASHLTWSLGMLFLLPPILTPGG
>NZ_CP019605.1|WP_077343305.1|2444332_2445085_-|DeoR/GlpR-transcriptional-regulator
MTVDRADREGAILARLSGEGALTVSALATDLGVSEVTIRGDLRALEEQGMLVRTRGGARPTTLKSILQREKLNVELKQRIATAAAAMVRDDDNVMIEAGTTTALVARLLAGRAGVQIVTNSALVFNNARINPSVSVILTGGVFRRESESFVGPLAERAVGDFNARLAFLGTDGFSPERGLTTRFVEGGQVAALMRGRAEETWLLADSTKFGQAGFVSFLPLAGITGVITDDGLPPGAVESLEEHTRVLVV
>NZ_CP019605.1|WP_077343303.1|2442952_2444317_-|2-oxo-acid-dehydrogenase-subunit-E2
MATVVVMPQLGNSVESCLIVSWLVAVGDAVAENAIVCEVETDKASMEVPSTAAGTVLALLWDEGDDVPVKEPLLVVGAAGEDPKAALAEIGWSGAGDDGSARSTEEPAAVDDEPSAPAADDAPRTAATGASSPRARALAQANSLDIASVSEGSGPGGRVIERDVRAALSNSTAAAARAGAHGSDAAGTGIGGRITTGDLAAPTEPAAEATPATAAASGREYPGPSTATPLKGVRKVIAERMMHSLASSAQLTYTTTARAAGLLALRAKLKGSPEELGLNGVTIGDLVGFAAIKTAAKHTNHNAHLADGTLTTFENVHLGMAVDTPRGLLVPTVRNANQMSLREFSATSKELAFAAIDGRIDPDLLAGATFTVSNLGGFGIESFTPLLNVPQVAILGVDAIFPRAVIHDDGTVGAEQRIGFSLTADHRVIDGADAARFLQDLVKYVENIDITVLG
>NZ_CP019605.1|WP_077343301.1|2441564_2442938_-|dihydrolipoyl-dehydrogenase
MSETNFDVIVLGGGPGGYIAAERLGHAKKKVLLIEAEALGGTCLNVGCIPTKALLGAAKTYDHARHAGAQGVHAPDITVDWAEMQAWKAKTVSTLVGGVGAAEKKAGVTVVKGHGRFDGPGRVTVGEETYSARHVILATGSVPVMPPIPGAADNPAVVDSTGLLAIEEIPARLAVIGGGVIGLEFASLFAMLGSEVTVIEMLPEIVPFMDDDLAAQLRKGLADVSFQLESRVTAIDGGVVRYSAKDGSEQSVEAEVVLMAVGRRPAVQGWGAENTGLEHSGKGVVVDERMRTNLPNVWAVGDVTGRSLLAHAAYRMGEIAAANILDPDAHLRGERMRWNTIPWAVYSNPEAAGIGATESQARAEGRAVGTVTVPGYLSGRFVAEAGVKAPGACKLVYDSTTGQVLGVNVLGTYASETIWGASVVLETELSIHDLRQVVYPHPTVSELIREAAWAAQV
>NZ_CP019605.1|WP_077343299.1|2439083_2441540_-|alpha-ketoacid-dehydrogenase-subunit-alpha/beta
MPRNLVVDPSNVRSTSAITAPSIPVNQYQPDFEAELATHGKEGLIDILHDMIAVRQFETMLNSIKTTGAWNGVEYNHRGPAHLSIGQESAVVGQASQLDPTDFVFGSHRSHGEILAKCFSAARKLDPAELERIMKEFLDGETLGLAERVSNDDLADLAENFIVYGTVAETFARSAGFNRGLGGSMHAFFAPFGSMPNNAIVGGSADIATGSAMFKRINEQPGIVIANIGDASMGCGPVWEAMMIAAMDQYRTLWDKGGNPPIWFNFFNNFYGMGGQTSGETMGYDILARVGAGVNPEAMHSERVDGLNPLAVADAVARKRKILESGRGPVLTDTITYRFSGHSPSDASSYRSKEEVELWEQHDGLKNYAAYLIDNGVLTSDDVDAMQAKFDERLTKVIALATQGEDVSPRVHMDFIETVMYSGGNKPSLDETREPELLQPLEENARVKSLAGKARYYKDKDGKPVSKAKTFSYRDALFEAVAHGFATDPTMAAWGEENRDWGGAFAVYRGLTELLPYHRLFNSPISEAAIIGAGVGYALSGGRALVELMYCDFLGRAGDEIFNQAPKWQAMSGGLLQMPLVMRVSVGAKYGAQHSQDWSALTAHMPGLKVYYPATPYDAKGMMNLALRGTDPVMFFESQKLYDIGEQFVTDGVPADYYEVPEGEPVVRREGKDLTLAVIGPTLYPVLETAEVLEKKYSLSAEVIDLRFLVPLNLDPIVESVKKTGRLVLATDAVNRGSFLHNVASSVQELAFDHLDAPVVVVGSRNAITPAAELEDEYFPQVEWLLDTIHEKILPLRDHTPTTTQTNGELARRWRHGL
>NZ_CP019605.1|WP_077343297.1|2437721_2439062_-|histidinol-phosphatase
MRTINEPTRTPGERVAALQDYLAGKPQFPDFVTESNNHVHTIYSFSPYTPAMAALKAREAGLMVVGSVDHDSAAAAGELTAAAALLGMGSVTGFECRVYLYSAEEVEQGTAPLHDRKLNNPDTAGIAYMTVQAIPARSRDAVADFLKPIREARLRRTAAMVDRANAILEPLGAELIDLETHIVGRSQFLAGGTITERHLLAAMAGMLIARFGRGESLVDGLREMGLNPSGALADRLADEDNPHLTFDLLGVMKAEFLDQIYVVPDRTECPTMAEVVAFAREIDAIPAYAYLGDVTASPTGDKKAEKFEDDFLEELFGELQRLGMPAVTYMPPRNTPEQMARIAELAREHGMVEVSGVDINTPRQQFNCPELQRSELAHLNEATWALVAHEKLADLDGSLGLFAPDSPVASLALVDRVGRYAELGRALVRDGLTVVEAAERLRGSGS
>NZ_CP019605.1|WP_077343323.1|2451361_2451799_-|RbsD-or-FucU-transport
MLNGPLIHPELLDALGRAGHGSKILITDGNYPHETGAPARARRIYLNLAPGLLGVGQILDVLKQAVPIEQAGIMTPAPDAPPELRPDKIEAHDEYRAALPGVEFVEISRWDFYDEAKKDDVGIVIASGEQRIYANLLLTIGVRQP
>NZ_CP019605.1|WP_077343325.1|2451812_2452799_-|LacI-family-DNA-binding-transcriptional-regulator
MSRRAPRANLRDIAEVAGVSMQTASRVVRGVDTVAEATRERVLRAVRELNYQPNLAARSLSARRTGSVHVIDAVPLYHGHATTFVAVCQHLSALDLHVSITVIRTDDFESLALTDLVPVGADGVIVLGGRSESNGWVSRVAAAVPTVYVGQAEALPDTVVGVAVDHHRGASLAVEHLVERGARRIVHVAGPQDWNDAQLRREGYEEACRAAGIEPTVLHADSWEAAAAGPLIDELPPDTDAIFAANDQLALRCLQGLQRSGRSVPGDVRVVGFDDAPGADSYLPPLTTIRQDFKTVGERAAAALGQLLDGGHPAAELIVPTLVVREST
>NZ_CP019605.1|WP_077343327.1|2452791_2454207_-|rhamnulokinase
MDTPTALAVDLGSSSGRIIAGTLRDGAIDEVEVHRFPHEAREVDGYLCWDLDHIWSEVVEGLREAVKQFPDAESVSVDTWGVDFALLGPDGRRLGPAVAYRDERTTRTLVRFQERLNDESAWAATGIAPATINAANQLFALIAEEPTLAEQVDQFLFLPDYFTYLLTGELVWSRSIASTSGLCRPGARDFSDEVFGALGIPRRWAGAVTPEHDVVGPCRIEGLTQLTVVRAGAHDTACAVHALQRDPSGETYFLSCGSWSVLGVLRDDPLLSDEARALGLTNEARADAGLRPLFNITGLWILQECQREWRAEGGVHDIVELIALAEDAPSTGYHIDPDEPQFALPKDMPNRVTRALAAQGADVASFTEGDIVRVILESLARRYARGVADLADLTGSAPQQLNLMGGGSRNRLLCQLTADALRVPVIAGPAEASSLGSLLAQFEIMGRVNATSRNAVIAKSARTVVFEPSHE
>NZ_CP019605.1|WP_077343329.1|2454385_2456155_-|L-fucose-isomerase
MTNYPKIGIRPIIDGRRNGVRESLEDQTMNMAIAVKELYEAELRYPDGSPVQVVIADSTIGRVPEAQAAAAKFKAENVGLTLSVTPCWAYGSETIDMDRTIPHAIWGFNGSERPGAVYLAAALAGHAQLGIPAFGIYGEEVRDADDPSIPDDVRQRLLDYAVAGLAVAQMKGKSFLSIGGVSMGIAGCVVKEEFWNYWLGMRNEYVDMVEIERRIQLGIYDKDEYEVAYAWVRENLKQGEDFNPEEWQRSEEDHEKWWEYIVKTVLVGRDLMVGNPKLAELGFGEEALGHGAILSGFQGQRQWTDFLPNGDLMETLLNTSFDWNGKRAPYLQATENDGLNGASMLFNYLLTNRAQIFSDVRTYWSADAIERVTGHRPEGRAAGGLIDLRNSGATTLDGTFAAKDGDGNNVIKPWWDLTDEDMQAMMDETTFHPANTGYFRGGGFSTHFRSAGEVPVTMTRINWIDGLGPVLQLAEGYTVELPDEVAKTIELRTDPGWPTTWFVPNITGEGAFTSVYDVMNAWGSNHGAISYGHIGHQLITMAAMLRIPVNMHNVERERIFRPKNWLGFGTVDLEGADYRACAQFGPLYN
>NZ_CP019605.1|WP_077343331.1|2456365_2457448_-|ABC-transporter-substrate-binding-protein
MRNLRSALALTSVLALGLTACGTSTDETTNEPAPAETTAAAPETTAAETETTPAETEPTDSEPAEAGDVPKGNGETIYLVSKGFQHRFWQAVKEGAEQAGQEYNYTIEFVGPQDETKVTEQLDMLKTALDSQPAAIGLAALDSGAAESLLTEIQAANIPIIAFDSGVDSDIPLTTVSTDNTAAAAEAAKHMAELIGNTGTVGLICHDQTSATGKQRCDGFQDWMAENAPDITVLEPQVAGEVGLAANTAKSMIQANPDLVGIYGTNEAAATGAIQGANESGKEGLTVVGFDSGKTQLEAIRNGSQAGAVTQSPVLMGYETVVAAIKAINGQELPETIDSGFAWYDASNIDDPEIAGNLYE
>NZ_CP019605.1|WP_077344315.1|2457517_2458477_-|ABC-transporter-permease
MSRILRSSIQQVFVFAALILIYIFFMIFAPNFAQPTIALDIVQQSAYVGVMALGATFVIATGGIDLSVGTGMTFAAVMAGVFLSGDWMNLPLAAGLLLTLLVGAVVGLINGLNISYLGLPPFIATLAMMMVARGLALVISDKSTISIKNSGYIWLASGELIPGVKNAILIFIIMAIIAAVLLNKTLLGRYALAIGSNEEATRLSGVNVKFWKTMVYIAAGVFMALGAILYSARFGFVQPAEGVGFELNVIAAVVIGGTSLSGGRANIIGTVVGALIMETLRKGLQMMGIAQEWQLVVTGIVVLIAVFVDIVRRKRQSTV
>NZ_CP019605.1|WP_077343334.1|2458518_2460036_-|sugar-ABC-transporter-ATP-binding-protein
MTKLLELKNVSKTFPGVKALQNVHLDLNAGEVLGLCGENGAGKSTLMKVLTGIYKPDPGAEIWLQGEKVQVRDVNHARDLGLSIIHQELNMVPDLTVAQNLYLGRPGSHKAGWVNDAQMNRDAGELFDKLGMSVDPKARIGDLSVARQQMVEIARALSYNSRILVMDEPTAALTIAETEALFGMIRDFVTPETGLIYISHRMPEIEEITDRVSVLRDGQYVGTVTTDEVEMREIISMMVGREVSGDARPRNKVTSDEIVLSVRDLNTKKLLHDINFDVRRGEILGFAGLMGAGRTEVARCVFGADPRTSGEIHVNGKKVDIRTAADGVRAGIGYLSEDRKTFGLLLDQDIKANTVMAAMKDFNIGGFILDNKIRTVGTEYSDRLRVKTPSVNQLLGKLSGGNQQKVVIAKWLVRNCDVLIFDEPTRGIDVGAKEEIYALLEQLCEQGKGIVMISSELPEVLRMSHRIAVMAHGRITGILENEDATQENIMELATVGKAQLNGEVA
>NZ_CP019605.1|WP_093665149.1|2460691_2461852_-|hypothetical-protein
MNDKLSDAFKSVIPEPPPTTGWVAGARRKRRNTRLAISGVAAAAVVALAIPVALNLPSVREPLVASPAPTPSATASSEPTQTPSVAPTQTSSPEPTIALTDIPSPDPVESPGAPSEPGPTLEPAGSDVPGSWACYNEDGRAPLLNANTGEDLPTGVGRAFLCGDGHEGFGVVGPLDPLVIEPDRIIELFEAQPEYVEVPDCGYEASDPYRIVLEYLNGDKWIISGYGEECQPLTDGTTQKAGEGFRDKVVALWQEQRAAVSPPAPPAATDALNCAPAQYPMIPMTLGDATAGIFCSQLDQEDPVEKVVLAPELVDRLVQAATSEAVAGYPEAAPGEASGTLILTNGWGDIFPVMRHGDQYAYVGDSEMMVWTPQDELAQALDNAFG
>NZ_CP019605.1|WP_077342173.1|2461848_2462361_-|SigE-family-RNA-polymerase-sigma-factor
MTEHQVDEAIGFERFVARRGRDLWRAAWLLTNDSQHAEDLVQTALAKTWGRYDAIGNDAQFEAYVRTTIYRTFVSWWRKMSWRNERPSETLADSASAEGSAHLRMDLMRALDELPRMQRAVLVLQYFEDLSIDEIAKQLGVSSGTVKTHSSRGRAALRDSAHLIEAGVLT
>NZ_CP019605.1|WP_077343340.1|2463746_2463971_-|hypothetical-protein
MDWCAPPSGVSDTPRRRNGEDERGRRLAETAPSDLLIATAIAERDPEGARFLMMRHVRTTREWLEGIWPEPLVT

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Crispr_ID: NZ_CP019605_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_8

2662665-2662737

Orphan

Consensus_repeat	Method
GCCGGCCGCTACTCAGGGAAACGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_8

>merge|NZ_CP019605|8|2662665-2662737|CRISPRCasFinder
GCCGGCCGCTACTCAGGGAAACGTAATGGACACCGGCCGCTCGTCCCTTGCCGGCCGCTACTCAGGGAAACGT

>NZ_CP019605|8|7|2662665-2662737|CRISPRCasFinder
GCCGGCCGCTACTCAGGGAAACGT	AATGGACACCGGCCGCTCGTCCCTT
GCCGGCCGCTACTCAGGGAAACGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077343707.1\|2659169_2659775_+\|YgjV-family-protein	unknown	unknown	gnl\|CDD\|226580
NZ_CP019605.1\|WP_143028245.1\|2652165_2652939_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP019605.1\|WP_077343701.1\|2652940_2654119_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|237864
NZ_CP019605.1\|WP_077343704.1\|2656552_2657923_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|273327
NZ_CP019605.1\|WP_162274555.1\|2672101_2672863_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP019605.1\|WP_077339774.1\|2661300_2662578_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NZ_CP019605.1\|WP_077343712.1\|2665434_2666352_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NZ_CP019605.1\|WP_077343702.1\|2655848_2656472_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|188632
NZ_CP019605.1\|WP_077343715.1\|2670313_2671978_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NZ_CP019605.1\|WP_077343713.1\|2666378_2667167_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP019605.1\|WP_077343697.1\|2650246_2652169_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|379247
NZ_CP019605.1\|WP_077343710.1\|2663831_2664512_-\|N-acetylmannosamine-6-phosphate-2-epimerase	unknown	unknown	gnl\|CDD\|234907
NZ_CP019605.1\|WP_077343709.1\|2662740_2663835_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP019605.1\|WP_077344325.1\|2672898_2674170_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP019605.1\|WP_077343706.1\|2657969_2659040_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP019605.1\|WP_077343708.1\|2659812_2660619_+\|cytochrome-b5-domain-containing-protein	unknown	unknown	gnl\|CDD\|365921
NZ_CP019605.1\|WP_068752174.1\|2669244_2670210_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP019605.1\|WP_077343711.1\|2664508_2665438_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP019605.1\|WP_077343714.1\|2667163_2669245_-\|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP019605.1\|WP_157633352.1\|2654257_2655499_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077343707.1\|2659169_2659775_+\|YgjV-family-protein	gnl\|CDD\|226580	COG4095, COG4095, Uncharacterized conserved protein [Function unknown].	0.000103119
NZ_CP019605.1\|WP_143028245.1\|2652165_2652939_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.31311e-08
NZ_CP019605.1\|WP_077343701.1\|2652940_2654119_-\|SH3-domain-containing-protein	gnl\|CDD\|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	1.12046e-07
NZ_CP019605.1\|WP_077343704.1\|2656552_2657923_+\|MFS-transporter	gnl\|CDD\|273327	TIGR00895, transport_protein, benzoate transport. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.09116e-60
NZ_CP019605.1\|WP_162274555.1\|2672101_2672863_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.15941e-38
NZ_CP019605.1\|WP_077339774.1\|2661300_2662578_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	8.26019e-24
NZ_CP019605.1\|WP_077343712.1\|2665434_2666352_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	1.16597e-83
NZ_CP019605.1\|WP_077343702.1\|2655848_2656472_-\|hypothetical-protein	gnl\|CDD\|188632	cd00452, KDPG_aldolase, KDPG and KHG aldolase. KDPG and KHG aldolase. This family belongs to the class I adolases whose reaction mechanism involves Schiff base formation between a substrate carbonyl and lysine residue in the active site. 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, is best known for its role in the Entner-Doudoroff pathway of bacteria, where it catalyzes the reversible cleavage of KDPG to pyruvate and glyceraldehyde-3-phosphate. 2-keto-4-hydroxyglutarate (KHG) aldolase, which has enzymatic specificity toward glyoxylate, forming KHG in the presence of pyruvate, and is capable of regulating glyoxylate levels in the glyoxylate bypass, an alternate pathway when bacteria are grown on acetate carbon sources.	6.6373e-20
NZ_CP019605.1\|WP_077343715.1\|2670313_2671978_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	9.31596e-104
NZ_CP019605.1\|WP_077343713.1\|2666378_2667167_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	1.12585e-111
NZ_CP019605.1\|WP_077343697.1\|2650246_2652169_+\|M15-family-metallopeptidase	gnl\|CDD\|379247	pfam13539, Peptidase_M15_4, D-alanyl-D-alanine carboxypeptidase. This family resembles VanY, pfam02557, which is part of the peptidase M15 family.	9.40186e-09
NZ_CP019605.1\|WP_077343710.1\|2663831_2664512_-\|N-acetylmannosamine-6-phosphate-2-epimerase	gnl\|CDD\|234907	PRK01130, PRK01130, putative N-acetylmannosamine-6-phosphate 2-epimerase.	2.24422e-101
NZ_CP019605.1\|WP_077343709.1\|2662740_2663835_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	1.337e-70
NZ_CP019605.1\|WP_077344325.1\|2672898_2674170_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.61805e-53
NZ_CP019605.1\|WP_077343706.1\|2657969_2659040_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	1.33351e-53
NZ_CP019605.1\|WP_077343708.1\|2659812_2660619_+\|cytochrome-b5-domain-containing-protein	gnl\|CDD\|365921	pfam00173, Cyt-b5, Cytochrome b5-like Heme/Steroid binding domain. This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.	1.32676e-15
NZ_CP019605.1\|WP_068752174.1\|2669244_2670210_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.32136e-98
NZ_CP019605.1\|WP_077343711.1\|2664508_2665438_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.83577e-62
NZ_CP019605.1\|WP_077343714.1\|2667163_2669245_-\|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.30065e-139
NZ_CP019605.1\|WP_157633352.1\|2654257_2655499_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.40293e-09

>NZ_CP019605.1|WP_077339774.1|2661300_2662578_+|IS110-family-transposase
MDVVHQRCAGMDVSKSDAKVCVRVQGRGSRRTSTEITTWPARASSILELGQYLVREKVSCVVMEATSDYWKPFFYLLSEAGLSVVLANPRQVRQIPGRKTDVADAAWLADLAAHGLVRGSFVPGQAQREIKDLVRHRTQLVRLSGQEIQRLEKLLESASIKLSSVISDINGVSGRRMLQALIEGERDPQVLAGLGCRLKASTDELAEALTGRFTEHHGFLARLHLHLIDDYAAQISELDARIEGYFTDNDPAPEGAMTWGKARALLSTIPGVSDTTAEQILAEIGIDMSVFDSPGKLASWAGVAPGLNESAGKRHSSTCRPGNKHLKGALGMAALSAANSKHTFLAARFRRLTRRGSQRAVVALSRTLITICWHILTTGEPYHELGADYYDKRRPGVAIRNALNHLRQAGLTITPTPEGLLLTQT
>NZ_CP019605.1|WP_077343708.1|2659812_2660619_+|cytochrome-b5-domain-containing-protein
MLDGVLGLPLHPLVVHAVVVLLPLVAVGVIALTVRPAWRPRLALPLLGLLAVAAVSAIVAMLSGRSLAERVGTPVQHEQLGTLLAVTAVAYLLLAGYWLWWVRRAEKEPTTPQNATGWVASIASVAVVALTIAVGHSGSSAVWAHWMVEAPATDPTPAASPSAVSSASSPASTPPSTTTPAPSAAPTSTVASLYSADMLADHATAEDCWAVIDGNMYDLTDWIALHPGGASRIEALCGTDATAAFTGQHDGQPNPAEALSRHLLGPVG
>NZ_CP019605.1|WP_077343707.1|2659169_2659775_+|YgjV-family-protein
MDWVELVGYIASAFVVLSFAMSSIVKIRSISLVGSAFYVAYGILIGSIPIILANGTIVVFHLVALSKEFSRKTELGATPIAPDAPFLADFLHSHTADIAKTQPEYEQAPSDTAFVLMREGMPAGAVMGNRDGDTLHLNLDYVLPAYRDSQLGKWIYGSRSSALRAHGIRKVTASPTTEVHRSYLGHMGFEPDGDRLVKALA
>NZ_CP019605.1|WP_077343706.1|2657969_2659040_-|LCP-family-protein
MGRAIDDGLEVFEDDDYQAEPRRRRGPGFVLLMLSVGVLVIALGVVGFYAARGLLALNSIDRDESLTPTDYTGRPALTKPKAPVGDEEPGKPPVNFVLMGADTTEGDAGRSDSLMVAHVTGDRQAVYLISFPRDMWVEIPGRGEGKINWAYAFGGPQLTVRTLEQMTGVRMDHTVSIDFDGFMRLTDAVGGVTVYNPWDSNQFAKGEVDLQGERALAYVRERYDLPNGDLDRAFRQRTVVKAIIRKLLTPETIANPVTFSNVIGQVADTMTVDDQMTNRYVTELALSMRITSGESIGLMQAPIEGFATIGGQAVDVVDWDGVAELSGALSGDTMDEYYAKHGNAQQIELGQVEPPE
>NZ_CP019605.1|WP_077343704.1|2656552_2657923_+|MFS-transporter
MSGHLTRSQRLDELPYTRKHNKLLMGSGVGWALDAMDIGLISFIMAALASEWQLSSTELSFLGSVGFVGMALGASLGGLLADRIGRRQVFALTLLIYGVATGLSALSTGLVMLIALRFIVGLGLGAELPVASTLVSEFAPRKIRGRVVVALESFWAVGWLAAALIGFFIVPMDNGWRWALALGAVPAAWSMVIRFGLPESVRFLEGKGRHNEAEQVVSKFEEAAGVTVRDEDKAPDAPLQAGAKVTKRELFGPRFRTRTIALWLTWFGINFAYYGAFIWLPTLLSSEGGMNLRDSFEFTLYMTLAQLPGYLAAAILVEVWGRRPTLVTFLGGSMVGAAAFALAPTLAASIAPGDDGAAYAIALTAGCVLSFFNLGAWGALYAITPEVYPTAMRAGGAGAATAFGRIAAMAAPLVVPLIVGAAGRATLFAVLGAMFAMAMVAAWFLPEYTDQALDEV
>NZ_CP019605.1|WP_077343702.1|2655848_2656472_-|hypothetical-protein
MDQPLRGLIVCLPDASLDDYIGAVEVLVQEGFSALALPASAEAFGDVAAIFGARITVGASRVALPQQIHAAADAGARFILADDTGSAIADAAAERGLPCYLPAMTPTEVRAVLEMPVAGALIFPADVVGHAMAARFQQLGLSDRVVPLGGIGAYAAGEWSKAGAPAVCVDTALLGDALTGGSLSSLRDRCGSFRSVEQRMLESKSTA
>NZ_CP019605.1|WP_157633352.1|2654257_2655499_+|hypothetical-protein
MNGTDSKMLGRTLRSALAVCLALTLSLVAAPALASSLEVTVTARDDQVTLEGTLTDDDRRAVRQEVVEASVGGTYVGQARTRGNGDFRLNFSGAQFGGGTHTVTVTFAGGRGASPASATGSFTVAGQPAAPTPPPAPPTTAPEPPPTQAPPEPEPEPEPEPEPTPTPEPPPAPAGPPTAALTATGPAAALSGDRITLTGQLVDEDGTGIDGVEVTVSDPEGDVPDVYALTSAGAFEATYAIPASQPDGPLTLTLAFDGAGTYEPATTTVVVPVTYQAPEVASPTPSALPSGGAATAEPSVAVSTAPPVDAVDEDEDNPWLGLTIVLVVLGGLTIITAAALLLRGGFSRRPAHTDVAGLDFLDEEMDSDDEPFFGGAGEPTAVLDDGRAVSFGDEPTQPMPPVPDSPSPRRGQD
>NZ_CP019605.1|WP_077343701.1|2652940_2654119_-|SH3-domain-containing-protein
MVDARRAAPDDSVAELGLVVPARRAASGALARPRMARLVMAPIAILSVVGLAAGLMVVPRPEVAAVTEPAKATVTLPLGISRSQSRPSLSTPTPSPSASPSPTTSPSPSTSPSPAPSPSVNAGPLPGLPIAPTPAPTPTPTVTAPAPAPSTPPAEKPAAVKAEKPAAPKVDYAKLGAEAGTRYSTASVNVRTGPGTGFDVRTSIAEGKAVTITDREVDGWRQVVISKRSGWIKGSFLTKTAPPKPSPKPAPKATATATKTQSSSGGGESSSSTSTAACAKASGIESGLTSRTRTVLRAVCAAFPKVSSYGGRRSGGGSYHSSGQAIDVMVSGDYGWQIARWARANAGSLGIIEVIYSQKIWTSQRSGDGWRSMSDRGSASANHYDHVHISVR
>NZ_CP019605.1|WP_143028245.1|2652165_2652939_+|hypothetical-protein
MSSVRRVVSAAALALAGVLAGCAGSDPTAPAPSVGMSASEAAPTPSAPTDPPTTEPSPSRAPSPTQTAPAPPPTAPNSLPPNDRAPTAPPPVPTAPAPSTAGGLSEADLTVPDGWEPTARPGSPEEGYLGNGTWVHATSPEHSAYAAIALGCTDVGAYPTPVAALEGTIVGPDGQPGVGLALEFGSQDDAAAYFAEWTRQAEACVGTVTEKVSLDDETWVGRRLLDTVWSEAVALSGTSVRLLILDDPDADVAAAVG
>NZ_CP019605.1|WP_077343697.1|2650246_2652169_+|M15-family-metallopeptidase
MAGPWRALLATAAVVASFVAAPPTADADEPFDVYTTPGTHEYNGRLWRTACEPYSSSVERCRTEIDASVVVYADGRFVEQRGWAFNNLTYKPSARDQWVDNILARPGEHVVDGRRWKTECDTPWTGDGACRSSIWTDTFHRRGSSYVKVPTWVFNNIVRFTPAQPTSAFCAAPASAAVQSVITASAPAPDNSPPTDAPAADDLASPPAPADVDAVTPATPSAPATADAAVAAPEPEAARPSNDVADEPSSPPADTVEAEEPASDVVPLSTPPPTISAVRHRDFSGGLYDRFGDIEVTGTSTSGAGWWLRVELRDSAGAVLHREDLTTGTGGAYRALVPGGFTGKATVVVISANGQASQAIEVQPATVTQTSATSLDPVAPATITGALTPAVDGVLISAQIRTAGGWLPVSYARTAADGSYALPYSHGSGQLGSADVRVCATTAWGATVPGPAATTLARARLANPEITATTADEVAATYRAGCPVGPSGLRTVRINQQSMDGRIYRGEIIVRTQRAAEVADVFRRTFDAGFPVYQMTNPNAFGADDPRMMAANNTSAFNCRRVVGNPYAMSPHSYGYAVDVNPWQNPYRDPTGKWWPSTDHVSRTPVVPGQLTESSAPVVAMKDHGWRWFSGWDWHHFEKR
>NZ_CP019605.1|WP_077343709.1|2662740_2663835_-|exo-alpha-sialidase
MITSVLTQRGDPFDGAAFTSPCYRIPALAVTPACRLLAAWDVRADWRDLPGPFDVVYRCSDDLGHSWGPLRVLRRHTASEGFGDASFVVGPGVVHCWYVSSAGRSFFDAEPGAGEGLRLWLASSFDDGQTWQHRDLTASLKPDDVTGMFASSGNGLTLREGARAGRLLQPFVLRTAAGQHFAAMAYSDDDGTTWALGERIGPDCDENKVTELPGGRVLLHARATPRRRWAVSDDGGVTFGDPVAHEQLVDPACNGGLSRWGSQVVATILNHPSERRELAIRRSADGGESWTPALGIDDGACAYSVALELPDGALAVAWESGDYDVIVFARIARDEVGFDGGEPTLRAIRGRAGAAAPPEVAPAR
>NZ_CP019605.1|WP_077343710.1|2663831_2664512_-|N-acetylmannosamine-6-phosphate-2-epimerase
MNAILDSLRGQLVVSCQAYPGEPMLDPRTMSQVAQAAVTGGAAAIRAKGLDDLRAIRAAVDVPIIGLVKEGATGVYITPTLESCIAVAETGCEIVALDGTRRDRPDGLTLAETVACLKERFPEVLVMADCGSAGDAAAAQEAGADIIGTTLVGYSGERPKTDGPDWEAIDEIIALADRPVLVEGRVHSPADAAESIRRGAWGVVVGTAITHPATITSWFAKAVAEA
>NZ_CP019605.1|WP_077343711.1|2664508_2665438_-|ROK-family-protein
MSHVVGVDLGGTKTAAARVAPDGTLGEIVSAPTPALRGGQAVLDVVADLVRRVGGDDTVGLGVGTAGVVDATVGRIISATDTFSDWVGTDVAGGLRQRLSWSDRPIEVINDVDAHALGEQWLGAARDHGSVLMVAVGTGVGGAVVLDGRLWTGAHHVAGEIGHVPTPGAEGLYCACGRPGHLEAVAAGPAIERMYGVDGVDGRAIMARAEAGEEKALAVVERAASSLGRAIAGLVTVLDPACVVIGGGVALAGDVWWGPLRRTIRDELVPILADIPVLPAAAGPSAAILGAAKRALDSVAAHPHQRSLT
>NZ_CP019605.1|WP_077343712.1|2665434_2666352_-|dihydrodipicolinate-synthase-family-protein
MPNFRGIVPPVITPMHTDGSVDFESLDRLVDHLIDGGMHGLFILGSSGQVAYLTDSERDEVTARCVKRAAGRVPVLVGTPDFTARRIAETAKRAEDLGADAVVVTAPLYALNDVAEIERHFRIIAEAVSVPVFAYNVPVRVHSYLGLATLMNLAKDGVIAGVKDSSGDDVGFRRLVAANRAAGHPLELLTGHEVMCDGMFLLGADGAVPGLGNVDPAGYARMWDAAQAGDWVAVRDEQDRIARLFEIAFVPQGRSGDAGGIGAFKQALASLGIIASGAMPAPMEPLTSDDVAGIETILREVGLLA
>NZ_CP019605.1|WP_077343713.1|2666378_2667167_-|ABC-transporter-ATP-binding-protein
MSTTPVVDLRDVHVVHKSRTGKLFRPDRVHAVNGVNISVSKGETLGLVGESGCGKSTLARVMVGLQPVTSGEVRFKGEQMKLNAAGRKKLGRAVSVVFQDPATALNPRMIVRDTLLDPFKVHGVLEPSERENRVKELLDLVGLPQSALDVLPRQISGGQRQRVAIARALALDPDVIIADEPTSALDVSVRAQVLNLLSDLKDQLGLGLVFISHDINTVRYISDRMAVMLAGQIVETGQADQIFANPTHEYTRTLLSAVPSLL
>NZ_CP019605.1|WP_077343714.1|2667163_2669245_-|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein
MLSPESRKKLQQPGLRFEGIRALPISSKIALAVISLLALVAIFAPIVAPFEPGASGLVPEDKIVYSEVTIEGVGTQLIPDNAIPPDGEFLFGTDDRGRDTFSRVLHGTRVSLLVGLAATGLALVVAAVLGSIAGTARKTVSEVLMRTLDIVMSFPGIALAAVMVTALSSRLPMLPVVVISIAFLYVPQLTRVVRANVLSQFGEDYVAASKVMGAKTWWILFKHVARNCLAPILVFATVLVADAIVFEASLSFIGTGISSVNAPTWGNMLSEGKALLLSGHWWVTFFPGLFILITTLSLNVLSEGLTDSFASPRIKTKVNVQSDEDKLKGEVGAAGIAASHISQVDSLRSRLAALREAELARSDRLVLANPDAKPLLEVKNLSISFPGAHGEVRIVDDVSFTVREGETMGLVGESGCGKSITSMAIMGLLPENARIEGSVKFDGRELLTLGPKDRNDLRGHEMSMIYQDALSSLNPSMLIRAQMKQLTKRGGQRTAEELLELVGLDPVRTLKSYPHELSGGQRQRVLIAMALTRNPRLVIADEPTTALDVTVQAQVVDLLNELREKLGFAMVFVSHDLALVAEVAHRITVMYAGQVVEQAVTRELLTNPTHEYTRGLLGAVLSIESGTGRLHQVPGVVPSPREFVAGDRFAPRSSHPQAGLTEKPTLHLVPGTDDHFYASTSELDALLEKEGLR
>NZ_CP019605.1|WP_068752174.1|2669244_2670210_-|ABC-transporter-permease
MSNFIRLLLRRVLAMPIMVLGATLLVFLVMSLSTADPARLALGESATPEALENYRERFNLNDPLLVKYVRYLGGLVQGDLGESFTGVPIGEMVARSFPITLQLTFIGLFLGVIIALVLGIIAALFRDKWPDQVIRFVSIASLATPSFWLALLFIQWFANIPGGLGWFPAVITNWINFSDDPAGYINQVTLPAVGMAIPLSGSLTRVVRTAMVEELDRDYVRTAIGAGIPKHIVVARNVLRNALITPLTVLGLRVGYMMGGAVVIEMIFNIQGMGNLIFQGIMRNDVNIVQGVTITIALAFIIINLVVDLLYVLVNPRIRSI
>NZ_CP019605.1|WP_077343715.1|2670313_2671978_-|ABC-transporter-substrate-binding-protein
MTNPQFDRRSLLKVAGVFGAAASISVGVAACSPANTTATTPAGTTPAGTASAGATTSAAAPATSTAAASEDGTITAGISYELGTNGYDPMTTTAALTVAANWHTMEGLTEIHPATREVYAALGADMPTQVDDTTWEVTLRDGAVFHDGSPVTTEDVVFSFERVLDPANTSLYASFLGFMEGVEAKDDTTVTIKTKYPFSLVPARLSVVKVVPKAAVEADASAYDLNPIGTGAYKMTDNGASSQQVVFERNDDYNGPYPARAATMTWQILPDAATRTNAISSDTVQAIDSVPAADLATLAQTKSVAAEQGFGLVFIMFNMGLAPMDEVKNRQGVMYALDYDRMTKVGMADLATPATSFLQKEHPSYQEASTVYTLDVEKAKSLFAETGLTSVRLLASNHDFFAAVRPIIKESLEAAGLTVNYEEKQSADVYGTIDSDPNSFDIVVAPGDPSVFGDDADLLLRWWYSGDVWTDTRMHWKGQESHTKMQELLDQAVAASGDEQQELWGQAFDLASETLPMYPLFHRKTPTAFDAETLVDFKPIAVTGLSFVDVGTTE
>NZ_CP019605.1|WP_162274555.1|2672101_2672863_+|FadR-family-transcriptional-regulator
MSGSREPQRLRQTIQAVKEHILTQGLKPGDPMPTEVQLVEELGVSRSNLREAVRTLVALDILEVRHGTGTFVGQMSMRPLVEGLTFKGVVLPGDDFKTLRQIVEVRQALDLALAPEIVAHWAGRDGAALYALCDAMAAQKARNDTFAAEDRAFHLTLTDVLDNTLYGQLVAAFWDVHTVVAPRLGVPTPRDIADTVAAHQAMCDAAIAGELETYQEAVLSHYAPLMRVLTGGAVSSDDAAGDGYGLEEVASPA
>NZ_CP019605.1|WP_077344325.1|2672898_2674170_+|MFS-transporter
MRRLFADTRPLQTPDFRRLWVANIVTVIGAQLTVVAVPAQIYAITGSSGMVGLTGLFGLVPLIVFGLWGGALADHMDRRRLLAITTLGLIVTSGLFWVQAFLGLNNVWVLLTLFSLQQAFFGVNQPTRTAILPKLLPADQLPAANALNMTVMSAGAIAGPLVGGALIPVLGYSWLYFADTLTLLATLYAVWRLPPLPVDRPRGAPGLKSVVEGLRYLGAHQILLLSFVVDLIAMIFGMPRALFPQMAHVSFGGPAEGGLQFALLYAAMPAGAVLGGVFGGWVSRVSRHGLAVLWAIVVWGAAMAVMGAAVGLAPWATNAMLGLALGMLVIGGAADMASAAFRQSILLGATDDAVRGRLQGVFIVVVAGGPRLADVVHGGAAEVVGPAWATGGGGLLVLTGIAVVAVASPAFRRYRVDLNGRAH

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Crispr_ID: NZ_CP019605_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_9

2808104-2808176

Orphan

Consensus_repeat	Method
CCTCGCGCAAAGCGCTCGTCACTG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP019605_9

>merge|NZ_CP019605|9|2808104-2808176|CRISPRCasFinder
CCTCGCGCAAAGCGCTCGTCACTGATCAGGGACCGATTCGACGGACGCGCCTCGCGCGAAGCGCTCGTCACTG

>NZ_CP019605|9|8|2808104-2808176|CRISPRCasFinder
CCTCGCGCAAAGCGCTCGTCACTG	ATCAGGGACCGATTCGACGGACGCG
CCTCGCGCGAAGCGCTCGTCACTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077344331.1\|2803832_2804204_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_CP019605.1\|WP_077343827.1\|2819279_2819876_-\|DUF4126-domain-containing-protein	unknown	unknown	gnl\|CDD\|379253
NZ_CP019605.1\|WP_143028221.1\|2818710_2819283_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NZ_CP019605.1\|WP_077343823.1\|2813344_2814514_+\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223525
NZ_CP019605.1\|WP_077343811.1\|2800889_2801099_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NZ_CP019605.1\|WP_077343809.1\|2797023_2798412_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP019605.1\|WP_077343818.1\|2808219_2808711_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_093664872.1\|2808866_2809610_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224115
NZ_CP019605.1\|WP_077343824.1\|2814563_2815688_+\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP019605.1\|WP_162274561.1\|2810283_2810892_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_CP019605.1\|WP_077343816.1\|2806495_2807113_+\|DUF3562-domain-containing-protein	unknown	unknown	gnl\|CDD\|319973
NZ_CP019605.1\|WP_077343820.1\|2809687_2810287_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319790
NZ_CP019605.1\|WP_077343810.1\|2798595_2800785_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP019605.1\|WP_077343814.1\|2804286_2804721_+\|arsenite-efflux-transporter-metallochaperone-ArsD	unknown	unknown	gnl\|CDD\|377741
NZ_CP019605.1\|WP_077343822.1\|2810881_2812081_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340911
NZ_CP019605.1\|WP_077343813.1\|2801955_2803308_+\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NZ_CP019605.1\|WP_077343817.1\|2807124_2807967_+\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|319973
NZ_CP019605.1\|WP_077343815.1\|2804720_2806478_+\|arsenical-pump-driving-ATPase	unknown	unknown	gnl\|CDD\|275109
NZ_CP019605.1\|WP_093664860.1\|2815965_2818386_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369025
NZ_CP019605.1\|WP_077343812.1\|2801110_2801419_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077344331.1\|2803832_2804204_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	9.29979e-18
NZ_CP019605.1\|WP_077343827.1\|2819279_2819876_-\|DUF4126-domain-containing-protein	gnl\|CDD\|379253	pfam13548, DUF4126, Domain of unknown function (DUF4126).	1.78661e-37
NZ_CP019605.1\|WP_143028221.1\|2818710_2819283_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	9.62715e-09
NZ_CP019605.1\|WP_077343823.1\|2813344_2814514_+\|NTP-transferase-domain-containing-protein	gnl\|CDD\|223525	COG0448, GlgC, ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism].	1.3476e-128
NZ_CP019605.1\|WP_093664872.1\|2808866_2809610_+\|hypothetical-protein	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	8.392e-63
NZ_CP019605.1\|WP_077343809.1\|2797023_2798412_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP019605.1\|WP_077343824.1\|2814563_2815688_+\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP019605.1\|WP_077343811.1\|2800889_2801099_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	6.47411e-12
NZ_CP019605.1\|WP_162274561.1\|2810283_2810892_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.63099e-16
NZ_CP019605.1\|WP_077343816.1\|2806495_2807113_+\|DUF3562-domain-containing-protein	gnl\|CDD\|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	4.04392e-40
NZ_CP019605.1\|WP_077343820.1\|2809687_2810287_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.06236e-28
NZ_CP019605.1\|WP_077343810.1\|2798595_2800785_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP019605.1\|WP_077343814.1\|2804286_2804721_+\|arsenite-efflux-transporter-metallochaperone-ArsD	gnl\|CDD\|377741	pfam06953, ArsD, Arsenical resistance operon trans-acting repressor ArsD. This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs.	6.73745e-49
NZ_CP019605.1\|WP_077343822.1\|2810881_2812081_-\|MFS-transporter	gnl\|CDD\|340911	cd17353, MFS_OFA_like, Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.34694e-76
NZ_CP019605.1\|WP_077343813.1\|2801955_2803308_+\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP019605.1\|WP_077343817.1\|2807124_2807967_+\|protein-tyrosine-phosphatase	gnl\|CDD\|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	7.55567e-43
NZ_CP019605.1\|WP_077343815.1\|2804720_2806478_+\|arsenical-pump-driving-ATPase	gnl\|CDD\|275109	TIGR04291, Arsenical_pump-driving_ATPase, arsenical pump-driving ATPase. The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).	0
NZ_CP019605.1\|WP_093664860.1\|2815965_2818386_+\|hypothetical-protein	gnl\|CDD\|369025	pfam06662, C5-epim_C, D-glucuronyl C5-epimerase C-terminus. This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.	2.09195e-21
NZ_CP019605.1\|WP_077343812.1\|2801110_2801419_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	9.29452e-34

>NZ_CP019605.1|WP_077343817.1|2807124_2807967_+|protein-tyrosine-phosphatase
MTRPSVLFVCVHNAGRSQMGAAYTHHLSGGAVEVRSAGSAPADSINPAVRDALLEEGIDISAETPKILTDEAVVASDVVITMGCGDTCPYYPGKRYLDWTLEDPAGQGVASVRPIRDEIKRRVLTLLGELGVEPVELPTPKPTLLFVCVKNGGKSQMAAALARRFGGDAVEVHSAGTHPGSKLNEESARSVEELGATFDGESPKPVDPDVLRRADRVVVIGTEADVQPVEGMRGTIEVWDTVEPSKDGIEGEERMRLVRDDIAARVKALLDDLQSPNLVR
>NZ_CP019605.1|WP_077343816.1|2806495_2807113_+|DUF3562-domain-containing-protein
MAIDRNSVQRQLIEDLAYAYGDVFGDAEIESAFTEAWELLSSRATVQNFLPVLVARRAREQLMARAQAEGRVVKHVPELLFVCVHNAGRSQMAAALAEHLSARRVHVRSAGSMPVDEINPVVVEALRERGIALNTAYPKPLSNDMVHAADVIVTMGCGDACPIFPGRRYEDWEVRDPAGQPLDVVREIRDDIQARVTTLLREILN
>NZ_CP019605.1|WP_077343815.1|2804720_2806478_+|arsenical-pump-driving-ATPase
MYSFLRDLPRFLFFTGKGGVGKTSLACASATHLADEGRRVLLVSTDPASNVAQVFGQPIGNRITAIRAVPGLDGIEIDPQQAADDYRERIIGPVRNLLPEAEIASIAEQLSGSCTTEVASFNEFTGLLADDSRIAGYEHVVFDTAPTGHTIRLLQLPGEWTSFLDDGKGDASCLGPMAGLDKTRATYASALARLSDPSLTRLVLVTRAQPSTLVEAGRTADELAHVGITEQHLVVNALLSDPGDDPLATAVHAREQRALSQLPPSLGRLTRTEVALRPNAVVGVDSLRELLNPHPQPVRPTGDTTAVEANGLAELIDELAAQDHGLIMCMGKGGVGKSTVAAAVALALAERGKTVHLSTTDPAAHLDDVLAGASDEHLSVSRIDPQAAIQAYRDKVMRTKGARLDDAGRAQLAEDLMSPCTEEVAVFGEFSHLVSQARRQFVVVDTAPTGHTLLLMDATGSYHRDIVRGMGPGQRPVTPLMRLQDPALTRIVIVTLPEATPVQEAADLQSELRRASIEPYAWVVNQSIAAARTSSPLLSARAATEAPHLTEVSRLAARVAVVPLLPDEPTGSRGLHTLIPEPATI
>NZ_CP019605.1|WP_077343814.1|2804286_2804721_+|arsenite-efflux-transporter-metallochaperone-ArsD
MPAIHVFEPALCCNTGVCGPELDESLVRFTADLDHLRSAGVDITRHNLANDPTAFATNPVVVNFLQVAGSPGLPLVLVDDVTVAAGRYPSRAELLRYAERPELGDLGLASAGSCCGSGPDDTAEVATGCCGGAPESAAARAACC
>NZ_CP019605.1|WP_077344331.1|2803832_2804204_-|helix-turn-helix-transcriptional-regulator
MSSAAGHLSDVDDCCAGAGCDLLAAQEADALASTFKALADPTRVRLLRYLAESAAGTACACHLPDALGISQPTLSFHMNKLHDAGLVAREKRGRWVHWTVRPESLAAVRGFLELPVGDQKCGS
>NZ_CP019605.1|WP_077343813.1|2801955_2803308_+|replicative-DNA-helicase
MTQAAVYDDRDLDRTPPQDLAAEQSVLGAMMMSKDAISDVVEVLRGVDFYRPNHETIFDAIINLYGRGEPADPITVAGELGKSGQLGKVGGAVYLHDLLSSVSIAANAIYYAELVRDKAILRRLVNASIRIAQLGYSGQGEVDKIVDEAQQTLFEVTDRNAAEDYKSLRELIEPTFDEMEAIASSGDALSGVPTGFTELDRITNGLHPGQMVIVAARPGVGKSTFALDVCRSAAIHHNLTTAFFSLEMSRTEIVMKILSAEASVPLGRIRGGKMDESDWQRVTDKSAILGEKNFFIDDSPNLTMMEIRAKARRLKQRHDLQLLAIDYIQLMSSGKKVESRQLEVSEFSRQIKLLAKELEIPVIALSQLSRNTEQRKDGIPQLSDLRESGSLEQDADIVLMLHRPEMYTQNPTDEERGLATFHIPKHRNGETGRIDALFQGHYSRFTNAPM
>NZ_CP019605.1|WP_077343812.1|2801110_2801419_-|metal-sensitive-transcriptional-regulator
MTTAEVQCHTTHGYTPEKTAYLRRLKLIEGQVRGIARMVEEDQYCIDVLTQVAAATSALKAVSLGLLNDHLAHCVADAARKGGPEADEKLDEAMQAIKRLVK
>NZ_CP019605.1|WP_077343811.1|2800889_2801099_-|heavy-metal-associated-domain-containing-protein
MITKYTVSGMTCGNCVSHVTEEVSEVEGVKNVNVTLEDGSMLVESDERVPFDSIIEAVREAGDYTVVEA
>NZ_CP019605.1|WP_077343810.1|2798595_2800785_-|cadmium-translocating-P-type-ATPase
MTNQIQLDIQGMTCASCAARIEKKLNKVDGIIATVNYSTERATVEAPDGVDPAMLIEVVEKTGYGATVPQPEAPKADEAAELKPRVLWSFALSIPVVLVSMIPALQFPGWQWAALVLSTVVVLWLGRSFHRATWTNLRHGATTMDTLVTLGTLTAYGWSVYAMVFGHAGMIGMKHEFEFNLGSQDALGFIYFEAAVTIISFLLLGRYIEARAKTESGAALRALLEVGAKQATLLVDGDERRVDAKQLRAGDLIVVRPGEKVAADGEVVEGRSAVDASVMTGESLPVEVEPGSDVVGGSVNTTGRLVVRATAVGEASQLARIAHMVEEAQTGKAEVQRLADKVSGVFVPVVLVIAAVTLVVHLVVGNGTTAALSAAISVLIIACPCALGLATPSALMVGTGRGAQLGTVIRGPQVLERARRVQTVVFDKTGTLTTGQMAVAAVQPADGVSEAELLAVAAAVEAASEHPIAQAVVAEVERPAPVVDFQNVPGRGVKGVVHGRTIYAGSPAFMAELGHSAPQWAGDLVGSVVEVATEERLLGRIIVADTVKDTAAAAIAQFKSLGITPVLLSGDNEKTARAVAAEVGIDDVRAGVTPQGKVEVIKELQAAGRQVAMVGDGVNDAAAIAQADLGIAMGTGTDAAIAAGDITLMRHDLAAAVDAVRLSRATLSTIKQNLVWAFAYNTAAIPLAALGMLTPMIAGAAMAFSSVFVVLNSLRLRGFRSINHGKSAG
>NZ_CP019605.1|WP_077343809.1|2797023_2798412_-|class-II-fumarate-hydratase
MDMRIETDSFGEIEVAADRYWGAQTERSLHNFDIGRDTFVWGRAMVRALGILKKAAAQANGELGELPADVADLIVQAADEVIAGNLDDHFPLVVFQTGSGTQSNMNSNEVISNRAIELAGGEMGSKKPVHPNDHVNRGQSSNDTFPTAMHIAIVNELNERLYPAIARLREVLAAKAEEYDDVVMVGRTHLQDATPVRLGQVFGGWVAQLDFALDGIRFADERARDLAIGGTAVGTGLNAHPDFGKLAAEKISAETGLEFRQADNLFAALSAHDSLVEVSGSLRVLADALMKLANDVRWYASGPRNGIGELTIPENEPGSSIMPGKVNPTQSEALTMVVARVLGNDAAVGFAGSQGNFQLNVFKPVMAHAVLESIRLLADGARSFTEHCAVGIEPNTQRIEANLQSNLMLVTALNRHIGYDLAAKIAKQAHKEGTSLKESALANGVSSEDFDRWVVPSEMTGR
>NZ_CP019605.1|WP_077343818.1|2808219_2808711_+|hypothetical-protein
MSESPHPALRLARHGKNDDGDRFVGLWVEVMVAGRQGSDARRVVKHFFRGDVAAALDSAGPGAFAVELRDAARIYVASCLTDPQYTSTMFGMKRLADDDVRAKIANETARALSALGVGQEPSGAELLPVALVGGYRDALGPGSEEALRAALGQTGARYGHLLT
>NZ_CP019605.1|WP_093664872.1|2808866_2809610_+|hypothetical-protein
MCQQTPAPRVAPLWEEWMERWPTAAALADAATADVLRAWGRLGYPRRALRLQETARAVDQLGGLPKDEAGLLALPGVGRYTAAAVVAFAYGRRSLVLDTNVRRVLARADGGVEFPHRHETAAERTRAWQFVPEDDAEAALWSASAMELGALVCTAKNPRCDQCPIADRCAWRAGGYPAWSGPERTAQPWEGTDRQCRGRIMAALRASSGPVSLADVAWPDQDQLASCAESLARDGLAVRVDGGLALP
>NZ_CP019605.1|WP_077343820.1|2809687_2810287_+|HAD-IA-family-hydrolase
MIRAVVFDLGQVLASPPNLYVDAADRLGVSAADYEANYWADRPAYDDGASDAEYWGPLLRTLGLTPTDDDIAEMARLDSELWIQVRPEAHALLRDTRAAGRTVAVLSNAPHAIAAAAEHSAWRADIDRLFISAPMGYSKPEPACFRQVQHELGLDADQIAFIDDRHPNVDGALAVGWHAHLWADDADTRAWLQELGVLQ
>NZ_CP019605.1|WP_162274561.1|2810283_2810892_+|pentapeptide-repeat-containing-protein
MNISDIRDDGTDYLAGETITGRLEPRDELRGVVFEGCTFTGCVLDEAVLRNCDFIDCRFDSCSLSQTKLPGTSFADCVLKGCRALSVAWTSVIAGTLSVAPLTFEGCKLTYSSFVGSTLRRWSFIDCDLSEADFSDAVLAATSFEHCNLAKARFVGADLRGVSLISSYNYYFDPREAKVAGLRVTPDGGAQLLRAFGIEVRE
>NZ_CP019605.1|WP_077343822.1|2810881_2812081_-|MFS-transporter
MRWLALVGGVLVQVVIGGVYAWSLFGRALQPELTAVQAAVPFEVAIGMIFVGASIGGRLQDRSSPRVVALLGVLLYAAGILLASLATSPERFWVLVVGYGVIGGFGLGMAYIVPVALLQKWFPRHSAVVTGLAVGGFGFGATVTSPAAQYLIGLSPESPALAFRPLGLAYLVVGALAAAMLVSPPATAAREGASSDFTPREALGTRQWYLLTAILTVAVAAGISLISMMAGAAVDVGGLDAAGAAAAVGVLALFNGAGRIGWAALAQRVGRLKVLGAILALEGLALVALPHATGFAFLALAAVVYLCYGGAFGTLPSTAGAFFGLTHAGAIYGLMLVGWSLAGVAGPLVSSALVAGAGGYTVAFTVMGLLALAGVLLPAVTRPPRRTNLDADQVPTATP
>NZ_CP019605.1|WP_077343823.1|2813344_2814514_+|NTP-transferase-domain-containing-protein
MHIPRTYALILAGGEGSRLEGLTDAKPKPVLPVGGTFRLIDISLSNLAQSHLSDIGIVEQYLPHSLNTYLSAGRPWDLDRNHGGLEVLAPFEGGPGEGFAKGNADSIYRQREVIRAFDPEYVLVLSADHLYTMNFLDVLSTHIEKEADLTIVTTLVDEDPSRYGVVQVDDAGTVTRFDYKPDDPEGRLVATEVFVYTASQLLAALEELTADGGELEDYGDQLIPWFVEHRKVVEHRHDDYWLDLGTLQSYWTANLQILDGNGVVLDDPRWRIYSALPQLPPARVMGGAEVHDSLLSSGSVVEGEVRHSVIGSAAIIEAGATVVDSVVLDGARIGPGVSLVNCIVDEGAQVTGGSQRGTGDTVTLIGDDGLIDTRQPLDPEAALPRGFPR
>NZ_CP019605.1|WP_077343824.1|2814563_2815688_+|alanine-dehydrogenase
MRIGVPREVKNSEHRVGMTPVGVHELVQRGHELIVEHDAGLGSSFTDDDYRKAGATVVDDAPEVWGSAELVLKVKEPTPDEFGLLREDLTLFTYLHLAADEPLVDALLDAGTTAIAYETVQLDSGQLPLLHPMSEVAGCLATQAGASHLLKHRGGRGILLGGIGGVANSEVLVLGAGVAGQSATNIAVGLGANVTLLDTDLGKLRAALARWGNRVTTLASSEIAIRDQLAGADLVIGTVLIPGARAPKLVSDEMIAGMKSGSVLVDVAIDQGGCFEPSRPTTHEDPTFRVHDSLLYCVTNMPAAVPHTSTWALTNATLPYVNALAEHGWRGAMEADATLRRGLSTHAGTLTSVPVAESFDRESVPAEDVLGIEC
>NZ_CP019605.1|WP_093664860.1|2815965_2818386_+|hypothetical-protein
MHHPGSTHPDLDGGGHRVRRAAPRMSAGRRVAAVMVAVVLALLGSVLTPHPPVASAVDVYSTPGYHEINGRKWFTRCESYTAQIERCWTYIWMTQTVMVDGKPTPVTDYHFNNLTYLAARRALWGNNPLAKTGEFESQGRKWKTSCQDDWTGPNGCRSFIWMKFLDYRQDEQGRGYFVSVEQWVFNNVVRFTREPDNPPDPTQNPSWTPTTPAPSPKPTPSPSSTPTTPPPVSPSAEPSPSIEPSPSVDPSPSVDPSPSVEPSPDPSASPTPTGTPAHECGAPMPAGYTINDEGRPYVINNPGYTPHDAYNPISIANYIQAINRGPGTAEQKRCAMVAAGEILVNGSVVDTYNGEVVRWLPYQFSFSANPSTPVLPPGWYSGLGQAGSMSALRMLYQATGEERWLTYAQELANALEVPYDEGGIKHYINVEGRRMLLWFEEYPTGDTPTTVLNGNNLVLIGLDMWADYTAELAEDGIFPYDERSAELFEEGLTAYEHVLPMLEVPTGGGIMSSYDLVRGYPAAPLRVVKLDDGKLDRVSLNGDLISMPVLDPAPTFPNRFLDPSFETSWQVIGPLSNTSIAGGVVTTTTTGTGWVGVAQNIPAGTFPAGRRVVVQFDARHEKAQAGVSAAPMASIQANCVSGNYQLARHTTVRGAEWATYSVEFPAPAADCQIRVQFLPTVSVVPGSTLQWSKPAIRLAEAKGAAHDPDYDILVFRTPRQELKLFGSGLYTVQAFADGRWQSIATLNATAWGRSVIIPERYTGRNLNYRYHESHIGELRQLASRSGWPVFAEYANRWVKTALNTPG
>NZ_CP019605.1|WP_143028221.1|2818710_2819283_+|hypothetical-protein
MRSWLIALVMVLSGVTLAVVPAAPAVACSCAVSSTAEYAERADLVAVGTITGREVPENATSSADDATWTVEIDKVYKGDATPTVPVLTALEGPSCGWDHVSSGQTIILFANLDGEDVRSDLCSGTGAFTPELDAELATLLGSPAAPTEAPAAAPDEGGLETRTVVGLALLIAAAVVLVAGAARRHHGVGG
>NZ_CP019605.1|WP_077343827.1|2819279_2819876_-|DUF4126-domain-containing-protein
MELLPMTFASGWASGINAYATVFILGLLGRFADTGGVPEGFQRTDVLIVMGILALIEVVADKVPVLDSIWDVPSTVIRPIAGALIGALIAGANGDLMTITLAAVGGVTALLSHLSKAGIRLAVNTSPEPVTNIGASVAGDVGVVGVTTLAVLFPVAAAVIAAILLAFMLWLAFKLGSRVRRGVRWMRQKFNQSAVDQT

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Crispr_ID: NZ_CP019605_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_10

3073822-3073911

Orphan

Consensus_repeat	Method
TGATCCCTGAGCTGGTCGAAGGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_10

>merge|NZ_CP019605|10|3073822-3073911|CRISPRCasFinder
TGATCCCTGAGCTGGTCGAAGGGTAACGACGTGACTGTGGTCACCGCCCTTGTGGTCAGACGACCCTGATCCCTGAGCTTGTCGAAGGGT

>NZ_CP019605|10|9|3073822-3073911|CRISPRCasFinder
TGATCCCTGAGCTGGTCGAAGGGT	AACGACGTGACTGTGGTCACCGCCCTTGTGGTCAGACGACCC
TGATCCCTGAGCTTGTCGAAGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_157633357.1\|3075402_3075558_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237489
NZ_CP019605.1\|WP_077344016.1\|3082260_3082797_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
NZ_CP019605.1\|WP_077344012.1\|3076158_3077445_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|99867
NZ_CP019605.1\|WP_077344352.1\|3084229_3085537_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP019605.1\|WP_077344004.1\|3063417_3063696_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077344005.1\|3063715_3065644_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_CP019605.1\|WP_077344017.1\|3082880_3084230_-\|L-serine-ammonia-lyase	unknown	unknown	gnl\|CDD\|273233
NZ_CP019605.1\|WP_093665089.1\|3078077_3079433_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225179
NZ_CP019605.1\|WP_077344014.1\|3079479_3080694_+\|TIGR04053-family-radical-SAM/SPASM-domain-containing-protein	unknown	unknown	gnl\|CDD\|274945
NZ_CP019605.1\|WP_077344002.1\|3056013_3057447_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP019605.1\|WP_093665087.1\|3057874_3063394_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP019605.1\|WP_077344006.1\|3065657_3065888_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NZ_CP019605.1\|WP_077344350.1\|3070444_3072226_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP019605.1\|WP_077344008.1\|3066882_3068280_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|273800
NZ_CP019605.1\|WP_077344010.1\|3072361_3073807_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP019605.1\|WP_077344009.1\|3068342_3070391_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP019605.1\|WP_077344013.1\|3077624_3077867_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077344015.1\|3081273_3082254_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|223538
NZ_CP019605.1\|WP_162274585.1\|3074100_3075417_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
NZ_CP019605.1\|WP_077344007.1\|3066004_3066682_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_157633357.1\|3075402_3075558_-\|hypothetical-protein	gnl\|CDD\|237489	PRK13745, PRK13745, anaerobic sulfatase-maturation protein.	1.10545e-10
NZ_CP019605.1\|WP_077344016.1\|3082260_3082797_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	4.34824e-39
NZ_CP019605.1\|WP_077344012.1\|3076158_3077445_-\|citrate-synthase	gnl\|CDD\|99867	cd06114, EcCS_like, Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS reaction is thought to proceed through three partial reactions and involves both closed and open conformational forms of the enzyme: a) the carbanion or equivalent is generated from AcCoA by base abstraction of a proton, b) the nucleophilic attack of this carbanion on OAA to generate citryl-CoA, and c) the hydrolysis of citryl-CoA to produce citrate and CoA. There are two types of CSs: type I CS and type II CSs. Type I CSs are found in eukarya, gram-positive bacteria, archaea, and in some gram-negative bacteria and are homodimers with both subunits participating in the active site. Type II CSs are unique to gram-negative bacteria and are homohexamers of identical subunits (approximated as a trimer of dimers). Some type II CSs including EcCS are strongly and specifically inhibited by NADH through an allosteric mechanism. Included in this group is an NADH-insensitive type II Acetobacter acetii CS which has retained many of the residues used by EcCS for NADH binding.	0
NZ_CP019605.1\|WP_077344352.1\|3084229_3085537_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	2.88956e-25
NZ_CP019605.1\|WP_077344005.1\|3063715_3065644_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP019605.1\|WP_077344017.1\|3082880_3084230_-\|L-serine-ammonia-lyase	gnl\|CDD\|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP019605.1\|WP_093665089.1\|3078077_3079433_+\|MFS-transporter	gnl\|CDD\|225179	COG2270, COG2270, Permeases of the major facilitator superfamily [General function prediction only].	5.70662e-88
NZ_CP019605.1\|WP_077344014.1\|3079479_3080694_+\|TIGR04053-family-radical-SAM/SPASM-domain-containing-protein	gnl\|CDD\|274945	TIGR04053, sam_11, radical SAM protein, BA_1875 family. Members of this subfamily of the radical SAM domain superfamily show closer sequence relationships to peptide-modifying proteins of bacteriocin and PQQ biosynthesis than to other characterized radical SAM proteins. Within this subfamily, targets are likely to be diverse. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP019605.1\|WP_077344002.1\|3056013_3057447_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.07753e-51
NZ_CP019605.1\|WP_093665087.1\|3057874_3063394_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP019605.1\|WP_077344006.1\|3065657_3065888_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	4.58086e-15
NZ_CP019605.1\|WP_077344350.1\|3070444_3072226_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	7.04163e-148
NZ_CP019605.1\|WP_077344008.1\|3066882_3068280_+\|TIGR01777-family-protein	gnl\|CDD\|273800	TIGR01777, Hypothetical_UPF0105_protein_Rv2216/MT2273/Mb2239., TIGR01777 family protein. This model represents a clade of proteins of unknown function including the E. coli yfcH protein. [Hypothetical proteins, Conserved].	1.84879e-102
NZ_CP019605.1\|WP_077344010.1\|3072361_3073807_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.95431e-47
NZ_CP019605.1\|WP_077344009.1\|3068342_3070391_-\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.40074e-78
NZ_CP019605.1\|WP_077344015.1\|3081273_3082254_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|223538	COG0462, PrsA, Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism].	1.11902e-120
NZ_CP019605.1\|WP_162274585.1\|3074100_3075417_+\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	4.60593e-08
NZ_CP019605.1\|WP_077344007.1\|3066004_3066682_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.75099e-40

>NZ_CP019605.1|WP_077344010.1|3072361_3073807_+|MFS-transporter
MPTPNRNVITVEGTDRTFSRVRILFVLLMSMGMSLIAVSSVNVALPALEQGLDASSSDLQWVLTGYALAIGVTLIPAGRAGDVLGRGAFFVVGAAIFTIASLACGLAPTPLLLNLARIVQGIGAGLFSPQVTGMIQQYFSGGGRAKAFALLGVVISASVAVGPVLSGAIISALGEETGWRWAFFIYLPVGLAAVVLALLWFPFETERQLRNPGRARSRIDLDPVGTVLVVAIVLAVMYPFMARQPLAWTLLAVAPVLLWIWIRWERGYAESGREPIVDLTLFRYRSYRNGLMVSGAVFLGVTSTFAVLALFLQSGLGVSAIFAGLIGLPNAISSAISATVTARYVLSHGRQLVILAVVLLLTGTLLSLLVAWLIGAFGISFWWLSPTLVLNGLGMGIFGSANQTLSMQDIPPAHGGTASGIKQTIERITTALGNAAITGLFFVVVADVSWVSGIAAAYAAIAVCLVVAFGLGLMDRRQHAR
>NZ_CP019605.1|WP_077344350.1|3070444_3072226_-|ABC-transporter-ATP-binding-protein
MATAKQLWPLYLGIVIGAIAIAVTSLMTPFVIARATDTVVGIVEGRGGAVSTLIWLAVALLVINLANSAISNLTGFWGDLMATRLRVILSQRYFHKLLRLPQRYYDNELTGTLISRLNRSITSITDFLQMFSNSFFPMLITVFAVLGISLFYSPWLALLLILIYPTFVWLTTLTSKRWQVWEHQKNEHYDIAGGRFAEVIGQMRVVKSFVTERRELDKFSGHYDAAVGLTREQSAFWHRMDLARRGVLDVVFFAIYAIIFVQTAQGQYSLGVMVMLIQLVTMARQPVTSMSYLVDTTQRAIAGSHEYFKVMNEIDEPNNPLEAQPSATVEWTDEDPVVAFRDVNFGYGDDDGDLVLKDIDLEINRGERVAFVGESGGGKTTLVNLIMKLYPATSGEIRVYGQSVRDVPTEELRREIGVVFQDASLFSGTIRENMAYGIADVTDEQLETAARRANALGFINGLKDRFDTEIGERGVKLSGGQKQRLSVARALLKDAPVLILDEATSSLDTKSERAVQAGLEELMEGRTTLIIAHRLSTISTVDRIVTLREGRIDEIGTPAELATTGGIYAELLALQGSTRKADKARLLAYDITS
>NZ_CP019605.1|WP_077344009.1|3068342_3070391_-|MFS-transporter
MTNPSQAPATFDFGAIKWAYIGLVIGMFTASISQTIVSPAIPRIVADLGGLAWYSWLSTIVMLVSAVITPISGKLADIFGRRRFYIIGLVLFMIGSMLSGLAMTFGFLIFARTVQGIGMGILMPLSQTILGAIIPARQRGKYQSYMGAVMGASQVAGPLLGGWVTDVSSWRWLFYISLPVGLAALVIVVRHLHVPELSIPAKIDYAGISTMTVGVSSTLLGISLGGATGWLTPQVLLLLGVGVTFVVAFVLIERKAEEPIVPLPLFRNSVFTVSTVAAFFMNMGMMAVLIYIPVYAQGVLRMTATESGLILMPMNVVLFAIGIVVGNLITKTGHYKEFAVAGGVFQIVGALLMLRLDAASSGLEVVVSTGVLGFGYGLAFQIYMLAVQNAVQRRDLGTATSSLQFFRNIGNTLGTAIAGTIMTTHLMSGIESRLTPELRERIPTGGLDPNAVLNPGKLAYLPVELADIMRASLADAMHAVFLLLPVLTALSLLATIFIKPLKLRDTLAQPEDRGREILDSTAMSSPDQERMLSPEDEHARRRERIMGAHLVLLAEQVHDDNPILRDAVADFGGGDLERGIQILRSTGTLLLTEDPAVMDEHEAFAVELSKRGQQQRMLSESVTARLDAVAELVSLHRAGTPTKPRIDTPDGIDGAGLRRALMMLDSALVADIATRRWDDTLL
>NZ_CP019605.1|WP_077344008.1|3066882_3068280_+|TIGR01777-family-protein
MNQPIERASDIPFPRERVFDWWLRPGSHERLSPPGWGEVIGGDRDARQVGDTVTLQPSHPLMSAIPGASLLKLRPVTARLDVVEPGERIVVALEHGRSRWTEETRFTDSGDGGTRVEQRVSGDYPASTGDAFQAQLTFLADQAEADLALVERLAARPSRIVVAGSSGLIGTQLVALLKMAGHDVTRLVRGTPEAPDEVRWDPASGEVPTDVIAGADAVVNLAGHTIGGRFTDRNKKLILQSRVDSTSTLANALRDRGSSAALIQASGIGFYGARRPAELLTEESRRGSGFLADVVDAWEAAAAPAVDAGVRTVFVRTGIALSYAGGALQRQVPLYLVGAGGRLGKAQQYQSWIGIDDLVRAYVHALFTPDLSGPINAVAPNPVTNAKFAETLGKVLQRPSLLPTPSFGPKLIVGDEGYDQLIDTDQRVSADKLLASGFEFTHPTLEPALRHTLLRQSGAGGHDSP
>NZ_CP019605.1|WP_077344007.1|3066004_3066682_+|Crp/Fnr-family-transcriptional-regulator
MSEDTCVAKVPIFRGLTPEEQREVADFARPVMASPNEQVMTAGSSRRRLLVVHSGRVRVVHLLPNGREHVVRVLGEGDVVGEDAFVLGRRPTHYAYADTDAQLCTFDHDDLARLVARYPGIALRMLQIQSERLANAERMLASMGGAEVGTRLAAYLLDLPSRQSDEGVLVELPMAKKDVASYLGTSPETLSRRLREFVDAGSIELRGRRGVLIRDVDALLTQAAL
>NZ_CP019605.1|WP_077344006.1|3065657_3065888_-|heavy-metal-associated-domain-containing-protein
MLTTTTHTTLRAEGFSCPSCVAKIEKGLGQLPGVSAATVHFASARIEVDHDPAVTSVDDLVAAVGKLGYVARPSAF
>NZ_CP019605.1|WP_077344005.1|3063715_3065644_-|cadmium-translocating-P-type-ATPase
MNARTRRWAIPAVAGTLIVSALVAGRLNTTVGDLLMLTAAVVAGTPVVIKAYRALAVRVVGIDLLVAVAAIGAVAIRNFWEAAAVTFLFALGHSLESATLAKTRSALAELVALAPTTATVIRDGAQVEVPAHAVGVGETVIVKHGGRVPVDGTVTAGQAAVDEAAITGESIPAEKSPDDDVYAGTIVADGFLTLTATGVGADTTLARIIHRVEEAQDAKARTQQFMERFSKWYTPGIIVLSLVVGLATMNLELALTLLVIGCPGALVISVPVALVAGIGRAARDGVLIKGGEFLETAARIDVVALDKTGTITRGEPELISILARDGFSDDEVLSWAARAEAGSGHPLAVPVVAAARDRGLAVPAVPDDVRTVPGHGVVATVDSREVAVGNLALVGHEPWADQAADELSAAGLTPLLLALDGTVVGALGVADTIRDGARELVEELRAIGVKRVLMLTGDNQQVADAIARQVGIDEVRASLLPDDKLAVITDLQSQGHSVAMVGDGVNDAPALAVADVGIAMGAAGSPVAVETADIALMASRLDRIPHALGLAKRTVGVMRSNIVIALATVGALLAGVLFGGVTMAIGMLVHEASVLVVIVNAMRLLRPTPSPPSRVLASDPLELRSTQGLSVATRSEVSSSAT
>NZ_CP019605.1|WP_077344004.1|3063417_3063696_+|hypothetical-protein
MTDDDLWDLTRTRLFWAGILANGVTSDDGAIAVEAALPARPTARGELLRLHQLATDELTGMLALLSDDEPRWADGEGTTVGDVRRLLDSDAG
>NZ_CP019605.1|WP_093665087.1|3057874_3063394_+|ATP-grasp-domain-containing-protein
MFKRIAIVNRGEAAMRLIHAVRDLNAEHPDQDQITTIALYTDAERSAMFAREADEAYAIGPASERPYLNHDLLARILTEARADAVWVGWGFVAEDAAFADLVESLGITFIGPSGDAMRKLGDKIGSKLIAEEVGVPVAPWSRGGVDSLDDALAAADSIGYPLMLKATAGGGGRGIRKVESADELVDAYHRTRDEAERAFGSGVVFLEKLVTGARHVEVQVIADGHGNAWALGVRDCTIQRRNQKIIEESASPLLSADQVAELKASAERLALAVGYQGAGTVEFLYHPGEQFFAFLEVNTRLQVEHPITEVTCDFDLVKAQIRVAAGEELAERPTELGHAVEARLNAEDPDRDFAPAPGLITRLDLPAGPGIRVDTGVAEGDTIPADFDSMIAKIIAHGRTRAEALGRLRRAMGETTVVIEGGATNKSFILELLDQPEVTGPTTARATPRRAEGTQPAIEWADTGWIDRVRADGGLVADAHAGVALVVAAIEAYEENLQIETERLLTTAHGGRPQTQLKPGGAVDLKLRGMVHNVVAYATGPERYRVTVDGQPVEASLQRLDDVHGRITVGEQHHRIVSATHGPVHLIEVDNVTHRVSRDEGGVLRSPAPALVVATPVAVGDEVEAGAPVIVLESMKMETVIPAPFAAKVKELHVITGSQVETMAPLVRLEPLGDGTEEAAAEGPAVDLPRPAVVASAEARAVRLQADLSATLLGYDVDPTARTLQAYLKVRDEVLADGGDVLGGEIELIALFADLAELSRNRPFGEEAQTELRVHSDREHFHRYLTTLDTARAGLPDLFVDRLGRVLRHYGVESLDRTPELEEAVLRIFVAQKRMASDVGIVLAILDRWIGEPAPNGGRNHAARDHLERLVRATQLRFPAVGDLARSVRFRWFDQPQVDAERAAILAGVDDEVDALAASPDAPDYDARIRRLAGIHEWTVGSLARRLARGTPEREPMLEVLLHKYYSEYGMGDIDHRTVDGRAVVTARYLLNERPRRFVGTVGTIDEAAPGGALERLLASEFDAREPGDDAVAELYLLWPDRPSSDDLGTALQDLLRGWAWDAAVQRVAVGVCQPDGHVEYRTFRFTDGQPWEDATIAGLPPMAGRRLDLWRLRDFDTTRLPAPEDVLLLECVAKSNPDDRRLVAMAQVRQLAVVRDEAGELVGLPHAERAVANCLEAIRRTRSARGSAGSKLDMNHVWVHVWPEIDLDIADIQPLQSRITPLSDGAGIEEVLCQGRFRRGDDVVALAVKFHALPGAGVTTTVSAPPSEPLKPLDDYAGKVLRARRRGLVYPYELSEALAGDGGSLTELDLDESGRLVEVDREPGRNKAGIICARVTTPTALHPEGVTRIVLSGDPTKGLGAVAEPECSRIIAAIDLAEEMGVPVEWFTLSSGARISMDSGTENMDWVGAALRRIVEFTQAGGEINVVVAGINVGAQPYWNAEATMLMHTKGILVMTPDSAMVLTGKQSLDFSGGVSAEDNYGIGGYDRVMGPNGQAQYWAPNLGAAMGILLGHYDRTYVAAGEDGPRRAETTDPSDRDVSDFPHVAAGSDFATVGQIFSVEHNPDRKKAFDIRTVIAAVCDQDHPRVERWAGMADAETAVVVDARIGGHSVSVLGIESKPVVRAGFPPTDGPDTFTAGTLFPRSSKKAARAINAASGNRPLVVLANLSGFDGSPESMRNLQLEYGAEIGRAIVNFDGPIVFVVISRYHGGAFVVFSKTLNENMTVLAIEGSFASVIGGAPAAAVVFAGDVAKRTAADTRVAELEAELRAAPPERKAELQIALADATAAVRAEKISEVAAEFDGVHNIHRAVAVGSVDRVIAPAELRPAIIETIEGYGR
>NZ_CP019605.1|WP_077344002.1|3056013_3057447_-|HAMP-domain-containing-histidine-kinase
MTAPATAFAPTATIRARIMWTMVLLAVASLITSGVVVAVLQDRNIHANVYAQLSRSKDELQVLASRGVDPATGAAFTGPSQLLQTYLQRTVIGPAEGELAFVDGRVAWVTEDAALRPENDEQLLAMVTPLATGNQIVIERMRTDQAHYYVLVAPVIFPNESGALVHVHDLDAAEAELRRTMTSYAVVALITIVVVVLLAWFAVGRLLKPIEQLREAAESIDERDLTSRVPVHGRDDLTALSVTINHMLDRVQRSVESQRRLLDDVGHELRTPITVVRGHMELIDPADPADVVQTRDLVIDEVDRMSVLVNDLLMLAKAGESDFVTPQWFDLATLTDQTFEKARTLGNRRWRLERVASAEAWFDPGRITQAWLQLAANAVKYSDEGTAITLGSALHRGEVFLWVKDEGIGIAPDQLETVRERFGRTREGASHAQGAGLGLSIVESIVRSHGGRLDIESREGEGSTFIIVFPLGPKEDV
>NZ_CP019605.1|WP_162274585.1|3074100_3075417_+|chromate-transporter
MEELKGGPRQVLSAMLTAGVIGFGGGSALIPVMERLTVHKGLLAAATYTRHVVVANITPGALPVKLAAAAGLNRGGARLSTASALVVALPGALATLLLMVGISALGEGGLNLLNFASVGITAFIIALLAGYVIKVHSHAGSAWPKFALITAVTAAATGANVIAAVGAELLGLPEPSGELPQLSAVQVILAALVAISVASLVAHRGEERSQSRLQLRSMTSIWRATAAFAVLTALGLGLFVVAAGTSGLAFGSLLALSTITAFGGGEAYIAVADGFFVQPGLIDAGVFYTQLVPIANALPGPILVKVGVGSSYLFGVAHGAWQGWALGGAGLLITVGACCALAVPVLGLYKQLKDHPVIVGIGRYILPVICGLLVSVAATMLEVSAGVMEDVVDPVGPALWVLVAAAAILTVLHVRKLAPDLVLLAVAGVLSLVALLLV
>NZ_CP019605.1|WP_157633357.1|3075402_3075558_-|hypothetical-protein
MTFVDGQPGQNYLCEGYYTFFSHAAPAIEQMARLISSGRPAADIMGVSHQQ
>NZ_CP019605.1|WP_077344012.1|3076158_3077445_-|citrate-synthase
MTDSGVLKYGELELELPIVEATQGNNGFDISKVLATTGATTLDPGFVNTASCTSAITFIDGDEGILQYRGYPIEQLAEKATFIEVAYLLIYGELPTQEQLDRFSGKISRRMMLDERLKELYRSFPRGAHPMQVLAAGIMALGAFHRDNLSVHDPAQVEEASLRLLGSMPTLAAYAYKSSVGEPFLYPQTRLGYVENYLRLSFGTPQEEYEIDPDIVRAFETLFILHADHEQNASTSTVRLVGSADANIYASMSSGVNALSGPLHGGANQAVLEMLARINDEGLDIKEFVSQVKDKKSGVKLMGFGHRVYKNYDPRAKIIKGHADQLLRKTGASNALLDMALELEETALNDDYFIERKLYPNVDFYTGLIYEAMGFPAQHFTALFALGRLPGWIAQWREQHADPARKIGRPRQIYVGEKDRTYSPINER
>NZ_CP019605.1|WP_077344013.1|3077624_3077867_-|hypothetical-protein
MRIGSAIVLIAVGAILAWAVNAEIPYISLDLVGYILIGAGVIGLIWALMASQRSRVTESRVVQDPNTGETVRRSESHDGL
>NZ_CP019605.1|WP_093665089.1|3078077_3079433_+|MFS-transporter
MPGLTPGALSATEAPRSRVISWALWDWGTQPFATVITTFVFSVYLTSSAFGPKDEVTMKLAWATGLAGLLIALLAPVLGQGADRTGKRMFHLRWQTWVLAAICAAMYFVAPAPEYFLLGAALLGAGNVISEIANVNYYAAIDQVSTPRNVGRVSGLGWGLGYLGGIAILLLIIAVRGSEFGPDDVRVAMLFCGAWTLVFTVPIFVALKDRRPDHVAPKIGILGSYRELFRSIKWLARTAPNTLFFYIAAALFRDGLAGVFTFGGVLAAGTFGFAFSEVVMFGVAANVIAGVATIGFGLIDDRIGPKTVILTSLVSLIALGTAIFIFHDGGKPVFWALGLAMCIFVGPAQSASRSFLARLIPEGHSGEMFGLYATTGRAVSFLAPTMFGVAIAVGATFTDSAEESAQHWGILGIVLVLAVGFVFALFVKDPSKHPVVAVPPEVRSMDPRRHQ
>NZ_CP019605.1|WP_077344014.1|3079479_3080694_+|TIGR04053-family-radical-SAM/SPASM-domain-containing-protein
MSPHPGSHPHEARKGVVRTLHHDAGERPHVLVWEVTRACQLACRHCRADAFTRADPRQLTTDEGKALLDSFASYGTPRPIVILSGGDAFERDDLEELIAYGTSIGLPIALSPSVTPLLTDERLASVREAGVKAFSLSLDGATPETHDSFRGIEGTFDDTMAAAKLVVKHGFRFQVNTTICRNNLRELPQLLATAMSMQAHMWYVLFLVPMGRGSNLEPLSPEEMEDVLHWLHDVSDRIAVKVTEAPNYRRVAIQRDDARTAGQPMPPTGELHAWLTEETERLLGEVTERRPPRPPIGVNSGRGFAFVDHIGDVYPSGFLPHRCGSVKEQSFPEIYAEAPMMKALRDPSSYEGKCGVCEFNWICGGSRARAHAMLGDPLASDPTCVWIPEAWRPSAPVIPELVEG
>NZ_CP019605.1|WP_077344015.1|3081273_3082254_+|ribose-phosphate-pyrophosphokinase
MKGIVVFSGSAHPELADEICGYLSLRRSGVKISRFSNDCLQAQLLANCRQRDVYIVQPLVPPTQEHLMELLLMVDAARGASAGQITAVIPHYAYARSDKKDSSRISLGGKLVADMLAAAGVDRVLTMALHAPQVHGFFSVPVDHLTALGVIADHYRERDLTNCVVVSPDLGNAKQATLLARLLNLPVAAGSKQRLADDRVVIDAIVGDVSGKRAIVLDDEIATGGSILEICNRLADFGAEEVSVACTHGLFTGNAREKLTSCGKIVEVVSTNTVPPPSNFPGLQVLSVAQLFAEAIDRIHNGRSVSKLFNDVDPSYAPPPQPEGLF
>NZ_CP019605.1|WP_077344016.1|3082260_3082797_-|NAD(P)H-dependent-oxidoreductase
MKVGIIVGSIRDGRVGRGIADWVYEIASKRDDAEYELIDLKEFNVPLLTSGTHPMAAKRKYDSEEVQAWSNAIDPCDAYVFVTPEYNHGVPGALKNAVDCLGEEWIGKTIAFVGYGSVGGVRAIEHWRSIVANFSMVDIRAEVNISLFADFKEGTFTPIDRRPDEVNALFDALVKAAS
>NZ_CP019605.1|WP_077344017.1|3082880_3084230_-|L-serine-ammonia-lyase
MALSVFDLFSIGIGPSSSHTVGPMRAAATFRASLPNDATRVTADLFGSLGATGHGHGTPGAVVLGLLGELPETVDPRLGAERVARARETGLLDVGHEIAFSMDDDITLHRRRELPLHSNGMIFRAYTGDEMVQERTFYSVGGGFVVDGAADGDARVVQDTTAVSHRFHTGDELLALCESTGKSISRIALENELSWRSEDEVRAGLLRIWAVMQECVQAGIATEGYLPGGLKVRRRAPELAAKLAVEGDSTDPMRGMDWVTLFALAVNEENASGGRVVTAPTNGAAGIIPAVLHYYARFVPGASDDGVVRFLLTAGAVGMIFKETASISGAEVGCQGEVGSACSMAAASMAAVMGGTPQQIENAAEIGMEHNLGLTCDPVGGLVQIPCIERNAIASVKAIAAARTALRGDGRHIVSLDKVIKTMRETGADMKVKYKETARGGLAVNVIEC
>NZ_CP019605.1|WP_077344352.1|3084229_3085537_-|MFS-transporter
MGWIVWGVGLFAYGVAVMHRTSLGVAGLEAADHFGTTPGIVSTFVVLQLATYALAQVPVGLVLDRVGSRVMVVAGSLIMGGSQALLAVSDDLPLAYAARVLLGIGDACIFNSVLRLLPRWFRPQLVPLLSQVTGMSASFGQIAAVAALLPLVKSGGWEYGLLIAAAVSLLPATAAAIWIRNAPPGTEPGVVSDRLREIPSNVLGVTKHPATQLGFWIHFTSGFSFTAFVFMWGLPYLVVGQGLSQAAAGGLLSLLAVSAMVAGPIIGTLTSRHPLRRSDLALIVIGAIILAWAVVLLWPGRAPLPLLILLVVVLSAGGPGTGIGFDFPRTNLPLTRLGAANGVVITGSFSGATLLILVMGVFLDLVADGRPYTPDHLRWAWALQAPFFLVGLAGILASRRRLRRLMAEQGVVVPSWREVVERIRRRRGRPGRRLH

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Crispr_ID: NZ_CP019605_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019605_11

3106294-3106401

Orphan

Consensus_repeat	Method
GCGCTCGCCGGCCCTGCTCAGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019605_11

>merge|NZ_CP019605|11|3106294-3106401|CRISPRCasFinder
GCGCTCGCCGGCCCTGCTCAGGGACCACCCTTCGACGGACGTTCCTTAGCTCTTGCGCTCGTCACTGCTCAGGGATCGATTCGAGCGCTCGCCGGCCCTGCTCAGGGA

>NZ_CP019605|11|10|3106294-3106401|CRISPRCasFinder
GCGCTCGCCGGCCCTGCTCAGGGA	CCACCCTTCGACGGACGTTCCTTAGCTCTTGCGCTCGTCACTGCTCAGGGATCGATTCGA
GCGCTCGCCGGCCCTGCTCAGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019605.1\|WP_077344030.1\|3099043_3099634_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274935
NZ_CP019605.1\|WP_077344034.1\|3103284_3103521_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227214
NZ_CP019605.1\|WP_077344027.1\|3093824_3096497_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|236880
NZ_CP019605.1\|WP_077344028.1\|3096721_3097795_+\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363
NZ_CP019605.1\|WP_077344031.1\|3099918_3101667_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380193
NZ_CP019605.1\|WP_077344032.1\|3101714_3102239_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_077344035.1\|3103553_3104540_-\|SPFH-domain-containing-protein	unknown	unknown	gnl\|CDD\|259800
NZ_CP019605.1\|WP_077344033.1\|3102249_3103167_-\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl\|CDD\|274584
NZ_CP019605.1\|WP_077344029.1\|3097859_3099017_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274934
NZ_CP019605.1\|WP_077344042.1\|3113460_3114267_+\|DUF4397-domain-containing-protein	unknown	unknown	gnl\|CDD\|379570
NZ_CP019605.1\|WP_077344036.1\|3104628_3105942_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340928
NZ_CP019605.1\|WP_077344045.1\|3115713_3118368_+\|pyruvate,-phosphate-dikinase	unknown	unknown	gnl\|CDD\|236446
NZ_CP019605.1\|WP_077344037.1\|3107250_3107841_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_162274587.1\|3106504_3107254_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|378058
NZ_CP019605.1\|WP_077344043.1\|3114374_3114938_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_CP019605.1\|WP_077344039.1\|3108595_3109597_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019605.1\|WP_162274588.1\|3114930_3115557_+\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|378389
NZ_CP019605.1\|WP_077344040.1\|3109689_3112050_+\|glycogen-debranching-enzyme	unknown	unknown	gnl\|CDD\|200465
NZ_CP019605.1\|WP_077344041.1\|3112219_3113107_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP019605.1\|WP_077344038.1\|3107884_3108505_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151

Protein	Function_ID	Function_description	E-value
NZ_CP019605.1\|WP_077344030.1\|3099043_3099634_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|274935	TIGR04037, predicted_flavoprotein, LLM-partnered FMN reductase, CE1759 family. This family represents a distinct clade within pfam03358. That family includes enzymes such as the NADH-dependent FMN reductase MsuE. Members of the present family regularly co-occur in genomes, typically as gene pairs, with members of TIGR04036, a probable FMN-dependent member of the bacterial luciferase-like monooxygenase (LLM) family. At least one member, RF\|YP_001509627.1 from Frankia sp. EAN1pec, is fused to the LLM protein. The function of these gene pairs is unknown.	1.84787e-74
NZ_CP019605.1\|WP_077344034.1\|3103284_3103521_-\|hypothetical-protein	gnl\|CDD\|227214	COG4877, COG4877, Uncharacterized protein conserved in bacteria [Function unknown].	7.99526e-17
NZ_CP019605.1\|WP_077344027.1\|3093824_3096497_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	6.09496e-07
NZ_CP019605.1\|WP_077344028.1\|3096721_3097795_+\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NZ_CP019605.1\|WP_077344035.1\|3103553_3104540_-\|SPFH-domain-containing-protein	gnl\|CDD\|259800	cd03402, SPFH_like_u2, Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.	2.49118e-124
NZ_CP019605.1\|WP_077344031.1\|3099918_3101667_-\|hypothetical-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	1.11464e-23
NZ_CP019605.1\|WP_077344033.1\|3102249_3103167_-\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	2.57097e-76
NZ_CP019605.1\|WP_077344029.1\|3097859_3099017_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP019605.1\|WP_077344042.1\|3113460_3114267_+\|DUF4397-domain-containing-protein	gnl\|CDD\|379570	pfam14344, DUF4397, Domain of unknown function (DUF4397). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.	4.8211e-20
NZ_CP019605.1\|WP_077344036.1\|3104628_3105942_+\|MFS-transporter	gnl\|CDD\|340928	cd17370, MFS_MJ1317_like, MJ1317 and similar transporters of the Major Facilitator Superfamily. This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.90597e-10
NZ_CP019605.1\|WP_077344045.1\|3115713_3118368_+\|pyruvate,-phosphate-dikinase	gnl\|CDD\|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NZ_CP019605.1\|WP_162274587.1\|3106504_3107254_+\|DUF1801-domain-containing-protein	gnl\|CDD\|378058	pfam08818, DUF1801, Domain of unknown function (DU1801). This large family of bacterial proteins is uncharacterized. They contain a presumed domain about 110 amino acids in length.	1.36912e-15
NZ_CP019605.1\|WP_077344043.1\|3114374_3114938_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	2.3373e-25
NZ_CP019605.1\|WP_077344041.1\|3112219_3113107_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	1.67809e-105
NZ_CP019605.1\|WP_162274588.1\|3114930_3115557_+\|anti-sigma-factor	gnl\|CDD\|378389	pfam10099, RskA, Anti-sigma-K factor rskA. This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.	4.45768e-09
NZ_CP019605.1\|WP_077344040.1\|3109689_3112050_+\|glycogen-debranching-enzyme	gnl\|CDD\|200465	cd11326, AmyAc_Glg_debranch, Alpha amylase catalytic domain found in glycogen debranching enzymes. Debranching enzymes facilitate the breakdown of glycogen through glucosyltransferase and glucosidase activity. These activities are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in Escherichia coli and other bacteria. Debranching enzymes perform two activities: 4-alpha-D-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33). 4-alpha-D-glucanotransferase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-alpha-1,6-glucosidase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. In Escherichia coli, GlgX is the debranching enzyme and malQ is the 4-alpha-glucanotransferase. TreX, an archaeal glycogen-debranching enzyme has dual activities like mammals and yeast, but is structurally similar to GlgX. TreX exists in two oligomeric states, a dimer and tetramer. Isoamylase (EC 3.2.1.68) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen and their beta-limit dextrins. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	1.15119e-171
NZ_CP019605.1\|WP_077344038.1\|3107884_3108505_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.47783e-36

>NZ_CP019605.1|WP_077344036.1|3104628_3105942_+|MFS-transporter
MTTSESVYTALVHRSSAADESIAEEDRSTVARNGLRIVGASALQASGDQATKASTVLPWLLHALGAPAALIGLLVPIRESGSMLPQAFLTPIVMRYRQRKWVVVVGHAVQAASVAVMTLIAAVGSGLWAGVGIVGALAVFSLGRCLTSIASKDVLGRTLPKGERGQVNGLATTASGIVAITLGLGLRLLGGQQLEATQLAWVLGGAAALWVLAAVLYAQVEEPDDDASADGESDGSWAALRLLRDDRDFRRFVTTRSFLLVSALAPPFIVSMSASSGADAVVGLGGFVVASGVASIIGGRLFGRMADRSSRRLMAFGAAASAAVVLLIVGIVALPGFSGETTVGTLVLVVGYFLLTLLHTGVRVGRKTYIVDMAEGDQRTLYVAVSNTAMGIILLVVGAISSAIALLGTVWALVFLAALGALGAVWGWRLPEVSQGS
>NZ_CP019605.1|WP_077344035.1|3103553_3104540_-|SPFH-domain-containing-protein
MTLPQTPDPSTDLDGDSVGGNTSVRPVGREGARVDIEEKKAWYIDGILAFFVALVVLGLASWQFVVAAMALDVGDAGGLRMFLAILLFLLALVMFSSLTIISPGDTKVIQFFGRYIGTIRRAGLLMTVPFTTKKKVSVKVRNFETNELKVNDADGNPVNIAAIVVWQVADTAKSVFAVEQYDEFVAVQSESALRHVATTHPYDYAGPGEESLRGSTELVADELADEVAARIAIAGLEVVETRISSLAYAPEIAQAMLQRQQASAIIAAREKIVEGAVSMVENALERLEEKNVVSLDEERKAAMVSNLLVVLTSESRVTPVVNTGSLYT
>NZ_CP019605.1|WP_077344034.1|3103284_3103521_-|hypothetical-protein
MGERKAVLLRLDPAVHDALARWAADDLRSVNAQIEVVLRDALKKAGRAPKDAAPLPKRGRPPAQPRSPSGKGHHRLPE
>NZ_CP019605.1|WP_077344033.1|3102249_3103167_-|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MIHVTQQRLLLVHAHPDDESSQSVATMARYLDQGAHVTLVTCTLGELGEIMLPEWSHFSPAELGAHRQVELESALDVVGVTDHLFLGGPGRYHDSGMTSDDTGRAAVPDEMPDNAFWRADLLEAANHLVEVIRSRRPQVAITYDPFGNYGHPDHIQAHRTLMYAVQLASSPSHRPDLGAPWQVSRVLWNTHNTSKWAEAYAIARERGLELWPGVDEDAATERFGPDPSQIVAVVETSPWLEKCRAALGAHRSQVNLEHPFWQFYSIMQELPGAGEAYLLGSGQPFPPGDGPATDVFEGIDFSEAT
>NZ_CP019605.1|WP_077344032.1|3101714_3102239_-|hypothetical-protein
MKFRLAAAAVAALALVGLSACSPDDAQPDATATVSAPAEGTSQPTDPGAGDATEPGGVQTQDDGTITFEGDVQTETIMVGPQEIEVPKGIKLPEESLVSDAQPAYVMIIDEDPSAVITAVTESAEESGYEVFAQPNEYTWVFVGHGNAVLLSASPQVQILSWGPEAMAEVLAEA
>NZ_CP019605.1|WP_077344031.1|3099918_3101667_-|hypothetical-protein
MKKLRLALALLVAVAAAPLAPAAPAAALDVYLEPGVHEINGRLWSTECEPYSQTKRCRTEIMATVVSYINGRFVPETDWAFNNLTYAPMPRAGWGDNPLANTGTWTNAGRTWRTECDTPLTGQNGCRTFLKASVVESVRAASGGTSYRWVTKEILNNMVRFSPPAAAPTPTPTPTPPAEPGPEWPRDLSQVKDAGLKSCIVLRSGVRTAADFDAEAAARLTRLNCSYSGVRSLEGMPYLPNLTGLDFSFTELGSLKGLPPQAKVSFLGLQSSNVASLAEVAHLPALTRLTMWDTPVSDLSPLRHTPSLTHLDARETLLTSLATLPSLGQLDFLSVGDGQVSTLRGMPSLPKLASLHLNNNPITSFEGMPSLGSLTLLQASGLQTPSFAGLPALPILKDLVASGNGLTSFAGLPPLPSLTYLNITHNELTSWAGLPTMPLLARIDASFNPLTTTAGFAPQPSLDTLQIDYTSVADLSGLPSLPKLQSLDASNSRVTQLGGMQVQPSLRMLSVGDSPVASLAGWTVQPVLRELYFRGHSITQVSPLAGQVSLRKLLFWSADGITDAHTLQPLVDAGCSVDILPR
>NZ_CP019605.1|WP_077344030.1|3099043_3099634_+|NAD(P)H-dependent-oxidoreductase
MTRIVVISGGLGTPSSTRVLGDLIVARLREELAGDGDLEVSVAELRELAHPIVDAMLTGFPTGELARVVDDVADADALVVVSPTFSASMSGLVKSFFDILEPDTLRGKPVLMAATGGTERHSLMLDFAMRPLFSYLGAEPVRTAIFAATSDFGGPGSAALGRRVRDGAADLARALTSAPRQREPEGFVDFETLLAG
>NZ_CP019605.1|WP_077344029.1|3097859_3099017_+|LLM-class-flavin-dependent-oxidoreductase
MQFGIFTIGDITPDPTTGRTPTEHERIKATVELALKAEEVGLDVFAAGQHHNPPFVATSPTTTLAFIAAKTERIILSTATTLITTTDPVRIAEDYAQLQHLAEGRVDLTLGRGNTGPVYPWFGQDIRDGIALAIENYELLHRLWREDVVNWQGKFRTPLHGFTATPRPLDGVAPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWPPSHTRRMVELYRRRYEHYGHGRADQAIVGLGGQVFMRKNSQDAIREFRPYFDNAPVYGGGPSLEDFSRETPLTVGSPQQVIERVLGFREYAGDYQRQLFLMDHAGLPQKTVLEQLDLLGEEVVPVLRQEFAKLKPAHVPDAPTHASLVAAAGAPDPPAERGPSADRWTGTRAEDGNRLTG
>NZ_CP019605.1|WP_077344028.1|3096721_3097795_+|branched-chain-amino-acid-aminotransferase
MPMFQVTRTATSTSDAARQAALADPGFGRYYVDHMAVVDYVAGDGWQEPRIVPMTEWALHPAAAVMHYGQEIFEGLKAYRRDDDSIWLFRPERNAARFVTSAQRMGMAVLPEELFLASVTELVDMEREWVPTSENEQSLYIRPFMIASEPYLGVREANTYRYAVIATPAGPYYSEPMKLWITPNYTRAAPGGTGTAKCGGNYAASLIATQEAYANGCGQVLWTDGAEHKWIEECGTMNVMFVTADGELVTPALGSILAGVTRESILMLAADHGLTAVERPISVDELLDGLESGQITEVFACGTAAVVTPIVGFNSPQRGEQVVADGQPGPKTREIRQHLVDIQYGRAEDKHGWTVKV
>NZ_CP019605.1|WP_077344027.1|3093824_3096497_+|LysM-peptidoglycan-binding-domain-containing-protein
MRLVRAVAALSALALLFVGVPWLLIAIGNPGHLLQVDWSTALLVGADSRVVLALVSVVAWLAWGILALTVLFEAVAVLTRERVVLRLPGTAWLRPAAAALVVAAFSVQGPSHAAATAGAPEAPPALASTADGARQAEVGEQEARARPVGRSYIVQSGDELWSVAERELGSGERWRDIVALNPGISDTTRLIPGEEIVLPGEPHQPRVVTVQPGESLWSIAERELGEPERWPEVFELNRDQVADPDQIDIGWQLEVPGGPDAGSVVDVEEIPGDGAAELPADDPAPPEPSVAPDSQPEPEPEPEPARPSPVVVEPSAGIEAAVVDRLMGRAQEPVAQSAAEQGEAAPLSSGRSADEVTMLLGSIGALMAAGVVAGLATRRRAQLLGRAVGQRLVPVSPQVGRFWTALGRRAADDDAATAMTPTTLVLGWDADRPVHHDLELARATAVTGQSEPLLAAALTSLTCAPWSSSVSLIVSGDTDWAAALDDPRVEGEPDADAAIARLLRQSSQRRLAMRQERLSTLRADPDRAEAWSPVVYVFTDPLAPAQLDALGDVLALGEVGVSVLFATNERPHVPAVLIEVGPAGASMDGTVFDPQLVERPAKRALLELLTATGTATTEPAPWWRPDALPANVTPLDPPEPDQPEDTAMTASSPQHPTLLLLGEVDLVGAAGDPPSRARGQCMEYCAWILAHPGARATTMMQSLLVADSTRRSNMSRLRSWLGSDDDGVAYLPDAYSGLISLDSRVSSDWEQFEGLLSGGVNVASTESLRRALRMVRGEPLGSYGFQWIWAEQLRADMVAMIVDAACVLADRALTKGDVEGALWAVGRGRLAQADDALAVREIHALSLAGRQDEAERAVVALNRAARAAGRDLAPEHAQRVQAALRSARVG
>NZ_CP019605.1|WP_162274587.1|3106504_3107254_+|DUF1801-domain-containing-protein
MPDNITRPTDSSVDEFLDSVTERRRHEARALIDMMRDISGEQPVLWGSSIIGFGTEHYRYDTGREGDQPGIGFSPRKASITIYFSEGFEHYGDELSRLGKHRASVSCLYLNKLADVDLDVLRSMLEASWHKQHEPLAKPTTVDEYIAQVPDAAREKFDDLRALVRGQLPEAEETLSYGIVGYRTGKGRARVYISGFKDHVAIYPVPSDESLPQELRAHIHGKGSIWFALDEPLPTGLIRRTVAALVEGR
>NZ_CP019605.1|WP_077344037.1|3107250_3107841_+|hypothetical-protein
MSARAAALALGGGLVAGVVMSFGQTVAPEPIAPLFNSAAPVVALAAAVALAGRGALTHVLFGASAGPLAMVGYYATTHLRGFGVSLQMVAFWSVAGVVSGAAMGLAVWALRRRAAPAWRVPAAALFPGVAIGEAAHGLVRISDTTPAAYWAGLALLGAVILAWLARSFLDTTLQRTLAVGFTAAAAAALFVLYGVA
>NZ_CP019605.1|WP_077344038.1|3107884_3108505_+|cation-transporter
MTQTTADGLRRAVLIVAALNLAYFFVEAGVAINIGSVSLYADSVDFLEDTAVNLLIFLALGWPLARRATMGKVMAVVILIPAVAALWQAIVKFQRPDAPDPLSLILTAGGAVVVNTICSVILLRHREHGGSMTRAAWLAARNDVIINIGIIVVGVITLFLVRNGWPDLILGLGIIALNARAAREVWEVAEEENLAAKALAGDIDDD
>NZ_CP019605.1|WP_077344039.1|3108595_3109597_+|hypothetical-protein
MTLKRRLAAALAAAAMLVWGRVATAAAEEVDMYSNPGGHANNGRLWQTDCEMYSSTVVRCETDIWASVVRYENGRFRTITGWHFNNLTYLPSYRGAWANNPLGVPSDSFTSNGRTWRTECDTAATGSGACRSYIWTNYAAYEGGAYRNKTGWVFNNLVRFAHDQIQPVKTVPPHVLDQVRLDFSGLGPLKAGVSHADLARLGYLTATGHECDAYRETTELRSRGIAVTFGRSDVLVQSRNIFTVDGARPGLSIGSIRGIYGSRFKVEAKENYGRTQYFGSVREGDRELIFRVRGVPDGYGGFEYAPTRTLVDTDVVYEISAGEYTDDVSWGGC
>NZ_CP019605.1|WP_077344040.1|3109689_3112050_+|glycogen-debranching-enzyme
MNHLIALNEQEWATASWPLGTHPSADGVTFAVHAPAASRIQLEIYPEALGADATDSFLMAKGVDGIWRAKVQGLQLGALVGFRAWGDNWPYVEGWEPGSDLGFVADLDEDGNRFNPNKVLFDPYAREVTHNVYTDLLHEYGVNDGVFGTGGEIVDGVPRRQIDTGRYAPKGIVIAEDTYVSPKPQIPGEKSVIYEVQVEQLTGHPSASRLTELLADEPGFADVVDIPEEYRGTYKGVGMMAPYLKAIGMTTIELLPIHETNASETGRPGASNAWGYMTLTFFAPNRQYSSDKSWGGPTREFKEMVSAFHDAGLQVYLDVVYNHTAEGGNWNGDVNTTGFTSLGGFATAEYYQMTTDKILVDGATGTSNQLNFSSEAAQRLVLDSVKYWTQDMQVDGFRFDLATVLGRKPDEAHPEDWAKQKRFFTDHPLLVAIADFAAEEGIEVIAEAWDLWGYEVGNFPRGWGEWNGRYRDAIRRYAKGDGNTIDFLDMMNGDYHHFHDSGGAQKTINFIDAHDGFNMVDLVSYQEKNNDQPFPFGPSDGGSDNNLSWDSGGSQALRRQRVRNFWTMLFFSRGVPMIVAGDEFGRTQNGNNNPWALDSVAMRNNYAMIPTNSPHLVPVADGLDAVYHDNLGTFETPANVNGLFRFATFLANLRQRHEALQQKSWGDLIPDNRDVSYLFHTPTREGFPEEGHRAVAIYINSPGDNFWVMVNMTEAPIDFVVPPAQDGLVWRRLVDTANWAEPACNFWREGEGMIVADGVTVEPWSIVVWHELPAPDGSRKIPVWKD
>NZ_CP019605.1|WP_077344041.1|3112219_3113107_+|kinase/pyrophosphorylase
MSAEPLEIHIIADSTGESAARVARAAITQFPTREFSIVRHRKMNSTAALLGALESVKSTGRPTAVFFTLVNEELSLLVRNFCTDADIPYADLMTDAMHALERITGIEADQVAMRPPGVEAEYFVRMSAIDFAVRNDDGSLPEALRECDICLVGPSRSGKTPLSIYLAYMGYKAVNVPLVPGIKPPKELDELDRWRIVGLTMDAERLLKIRGERVRGMGGFGTKDGYADLAKIYDELDEIAKVHRRLGCPIIDTTGVAIEEAASRIVDIVDDRARRVGSRLRRPPGIVRPGSDFKP
>NZ_CP019605.1|WP_077344042.1|3113460_3114267_+|DUF4397-domain-containing-protein
MKLSRIIVAGSVALAASLGSASVAFADDHNTSNVSILHGVPGATVDVYVNGDALLTNFAPGTLTDPLELPEGSYDLKVVAPGAGADGEAIIEANDVAVPAGADITVVAHLTDAGVPALTPFVNDTSMSEEGGRLTVRHVAAAPAVDIRAGGAVAVSNLANPDEAKLDLAAGTVPADVVAAGTDTVVLGPADVTIAAGSNTIVYAWGSLEDENLALAIQNVALDTAGMPHTGAEGPANSTNGLVAATLLLAGVAVTVVMAQRNRAGNIA
>NZ_CP019605.1|WP_077344043.1|3114374_3114938_+|sigma-70-family-RNA-polymerase-sigma-factor
MAPDDRQTPVGLLATQLAAGDESALREAYHRWSRLIHTIARNSLGSAADADDVTQQVFIAAWNSRASLRASDEALPAWLIGICRMKVIDALRARSRGFRNEEAMMSEALDEPVVRNLDGVIDSVVVRDALAALGDPRAQILTMVYLEDKTHDDVARHLSIPLGTVKSHVRRGLERLRSVFEEVDSLV
>NZ_CP019605.1|WP_162274588.1|3114930_3115557_+|anti-sigma-factor
MSEESNYTLDDVARRFRRAVAQDPQWSDPSPGTWEAIAAATGVAPSQSPAPDASEPQAAPSVSRRGWLFGAGGLVVGAIAGAVGMRMADGFFDDLEEAVRRAELTPLDRPDQRLGTAELLRQQFGYSLSVEVPEGVSNPDGYVEVWLINTDGQRMVSVGVFAADSIGRFSIDEALIEGGYLIVDLSNEQFDDEPRHSGDTIMRGELRS
>NZ_CP019605.1|WP_077344045.1|3115713_3118368_+|pyruvate,-phosphate-dikinase
MSEERYIYDLADGDGTMRSLLGGKGAGVAEMNRVGVPVPDAFTVTTTACVQTMNNNGEWPDGLADQIAQGLKRLEERTGRTLGGSERPLLVSVRSGAVHSMPGMMDTILNLGISDESVVALAEEFGNERFAWDCYRRFIQMYGEVVEGVPQNLYEDALSELKHHRGVDQDTDLDADDLKGLVETFKQISNDHLGGAWTADPREQLNRAVNAVFKSWGNPRAEVYRRAHNIPASLGTAVNIMQMVFGNRGDTSATGVCFTRNPSTGEKALYGEFLVNAQGEDVVAGIRTPRPMGEMKDVLPEAYEQLVATMHKMEQHYKDMQDMEFTIEDGKLYLLQTRNGKRTAAAALKVASDLVDEGVISQEEALLRIEPGQLDQLLHPAIPPEHGQIPIAKGLPASPGAAVGGVVFDADTAAERGSKGEPVVLVRFETTPDDIHGVIEAQGILTAHGGMTSHAAVVARGMGKPCVAGAHGIKIDPVGKTLTIGDRVIKEGETITLDGTTGDVYGEKIELIPPQINEDFERVVQWADSVRRLGVRANADNFEDATKARELGAEGIGLCRTEHMFMAQDRLPAVRRMILAESSEQRAAALEEILPMQQSDFEGVFTAMKGLPVTVRLLDPPLHEFLPNLVEQSLLVQRLEMSGGDSEELGEAKQTLAQVKRLHELNPMLGTRGCRLAMLYPEIPDMQTRAIVRAALAVREREGETVGVEIMIPLVALSQELETQRAIVVAAVEDELAQAGAELDYTVGTMIELPRAALIADKIAEHADFFSFGTNDLTQTAIGISRDDAENGFLTQYVMDRVLERNPFETIDVEGVGQLVEMGVERGRSVKPKLKTGVCGEHGGDPDSVEFFHGAGLDYVSCSPFRVPIARFAAAKAVLQEKKA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_CP019605.1	66773-66799	0	1.0
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_CP019605.1	2065119-2065145	0	1.0
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_CP019605.1	2901378-2901404	0	1.0
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_CP019605.1	2901571-2901597	0	1.0
NZ_CP019605_6	6.1\|2354306\|47\|NZ_CP019605\|CRISPRCasFinder	2354306-2354352	47	NZ_CP019605.1	2354341-2354387	0	1.0
NZ_CP019605_2	2.2\|799042\|18\|NZ_CP019605\|CRT	799042-799059	18	NZ_CP019605.1	798970-798987	1	0.944
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_CP019605.1	497310-497336	1	0.963
NZ_CP019605_11	11.1\|3106318\|60\|NZ_CP019605\|CRISPRCasFinder	3106318-3106377	60	NZ_CP019605.1	143141-143200	1	0.983
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	NZ_CP019605.1	798970-798999	2	0.933
NZ_CP019605_2	2.3\|799078\|21\|NZ_CP019605\|CRT	799078-799098	21	NZ_CP019605.1	2196588-2196608	2	0.905

1. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to position: 66773-66799, mismatch: 0, identity: 1.0

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
ggtccctgagcagtgacgagcgctctg	Protospacer
***************************

2. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to position: 2065119-2065145, mismatch: 0, identity: 1.0

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
ggtccctgagcagtgacgagcgctctg	Protospacer
***************************

3. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to position: 2901378-2901404, mismatch: 0, identity: 1.0

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
ggtccctgagcagtgacgagcgctctg	Protospacer
***************************

4. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to position: 2901571-2901597, mismatch: 0, identity: 1.0

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
ggtccctgagcagtgacgagcgctctg	Protospacer
***************************

5. spacer 6.1|2354306|47|NZ_CP019605|CRISPRCasFinder matches to position: 2354341-2354387, mismatch: 0, identity: 1.0

gacgctactgagggagacggaatgggccagttcgggacgctactgag	CRISPR spacer
gacgctactgagggagacggaatgggccagttcgggacgctactgag	Protospacer
***********************************************

6. spacer 2.2|799042|18|NZ_CP019605|CRT matches to position: 798970-798987, mismatch: 1, identity: 0.944

cttcggctcttccttggg	CRISPR spacer
cttcgcctcttccttggg	Protospacer
***** ************

7. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to position: 497310-497336, mismatch: 1, identity: 0.963

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
ggtccccgagcagtgacgagcgctctg	Protospacer
******.********************

8. spacer 11.1|3106318|60|NZ_CP019605|CRISPRCasFinder matches to position: 143141-143200, mismatch: 1, identity: 0.983

ccacccttcgacggacgttccttagctcttgcgctcgtcactgctcagggatcgattcga	CRISPR spacer
ccacccttcgacggacgttccttagctcttgcgctcgtcactgctcagggaccgattcga	Protospacer
***************************************************.********

9. spacer 2.1|798994|30|NZ_CP019605|CRT matches to position: 798970-798999, mismatch: 2, identity: 0.933

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
cttcgcctcttccttgggctcgggcttcgg	Protospacer
***** ********************* **

10. spacer 2.3|799078|21|NZ_CP019605|CRT matches to position: 2196588-2196608, mismatch: 2, identity: 0.905

ctgcgccggcgtcgggtcggt	CRISPR spacer
ctgcgccggcgtcaggttggt	Protospacer
*************.***.***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019605_2	2.3\|799078\|21\|NZ_CP019605\|CRT	799078-799098	21	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	826141-826161	1	0.952
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	86093-86122	4	0.867
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_AP017296	Nostoc sp. NIES-3756 plasmid pNOS3756_1, complete sequence	45436-45462	5	0.815
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	MT711888	Pseudomonas phage Dolphis, complete genome	14900-14926	5	0.815
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	MK291444	Paracoccus phage vB_PthS_Pthi1, complete genome	20652-20681	6	0.8
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	172321-172350	7	0.767
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	MH572287	Microviridae sp. isolate SD_SC_46, complete genome	566-595	7	0.767
NZ_CP019605_3	3.1\|1785464\|27\|NZ_CP019605\|CRISPRCasFinder	1785464-1785490	27	NZ_CP024936	Paraburkholderia graminis strain PHS1 plasmid pPHS1_P, complete sequence	235552-235578	7	0.741
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	NZ_CP048789	Roseobacter ponti strain DSM 106830 plasmid p1, complete sequence	23055-23084	8	0.733
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	MH572307	Microviridae sp. isolate SD_SC_52, complete genome	572-601	8	0.733
NZ_CP019605_2	2.1\|798994\|30\|NZ_CP019605\|CRT	798994-799023	30	NZ_CP020572	Thermus aquaticus strain YT-1 plasmid p61, complete sequence	54910-54939	9	0.7
NZ_CP019605_4	4.1\|1982450\|33\|NZ_CP019605\|CRISPRCasFinder	1982450-1982482	33	MT310853	Microbacterium phage AvGardian, complete genome	7116-7148	11	0.667

1. spacer 2.3|799078|21|NZ_CP019605|CRT matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 1, identity: 0.952

ctgcgccggcgtcgggtcggt	CRISPR spacer
ctgcgccggcgtcgggtcggc	Protospacer
********************.

2. spacer 2.1|798994|30|NZ_CP019605|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.867

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
cttcggctcttccttcgcctcgggctccgg	Protospacer
*************** * ********. **

3. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to NZ_AP017296 (Nostoc sp. NIES-3756 plasmid pNOS3756_1, complete sequence) position: , mismatch: 5, identity: 0.815

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
gtaccctcagcagtgacgagcgctggg	Protospacer
*  **** ****************  *

4. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to MT711888 (Pseudomonas phage Dolphis, complete genome) position: , mismatch: 5, identity: 0.815

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
ggtcgctgaacagtgacgagcgcatcg	Protospacer
**** ****.************* ..*

5. spacer 2.1|798994|30|NZ_CP019605|CRT matches to MK291444 (Paracoccus phage vB_PthS_Pthi1, complete genome) position: , mismatch: 6, identity: 0.8

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
cttcggcgcttccttggcctcggccgtcgc	Protospacer
******* ********* ***** * * *

6. spacer 2.1|798994|30|NZ_CP019605|CRT matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
cggcggcgcttccttggtctcgggctccgc	Protospacer
*  **** ********* ********. *

7. spacer 2.1|798994|30|NZ_CP019605|CRT matches to MH572287 (Microviridae sp. isolate SD_SC_46, complete genome) position: , mismatch: 7, identity: 0.767

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
cttcggctcttccttggcctcagaaaggtg	Protospacer
***************** ***.*.   * *

8. spacer 3.1|1785464|27|NZ_CP019605|CRISPRCasFinder matches to NZ_CP024936 (Paraburkholderia graminis strain PHS1 plasmid pPHS1_P, complete sequence) position: , mismatch: 7, identity: 0.741

ggtccctgagcagtgacgagcgctctg	CRISPR spacer
tcagcctgggcagtgacgagcgctcgc	Protospacer
    ****.****************

9. spacer 2.1|798994|30|NZ_CP019605|CRT matches to NZ_CP048789 (Roseobacter ponti strain DSM 106830 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
gtctggctcttccttgtgctcggtcttttc	Protospacer
 *..************ ****** ***

10. spacer 2.1|798994|30|NZ_CP019605|CRT matches to MH572307 (Microviridae sp. isolate SD_SC_52, complete genome) position: , mismatch: 8, identity: 0.733

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
cttcggctcttccttggcctcaaaagggtg	Protospacer
***************** ***...   * *

11. spacer 2.1|798994|30|NZ_CP019605|CRT matches to NZ_CP020572 (Thermus aquaticus strain YT-1 plasmid p61, complete sequence) position: , mismatch: 9, identity: 0.7

cttcggctcttccttgggctcgggcttggg	CRISPR spacer
ttcgggctcttccttgggcccgggcaccac	Protospacer
.*. ***************.***** . .

12. spacer 4.1|1982450|33|NZ_CP019605|CRISPRCasFinder matches to MT310853 (Microbacterium phage AvGardian, complete genome) position: , mismatch: 11, identity: 0.667

cctaccgccgcccccgacctcagggcaggctgc	CRISPR spacer
gacgatgccgccccagacctcagggaaggcgag	Protospacer
  .. .******** ********** **** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

518330 : 531793

Shigella_phage(33.33%)

integrase,transposase

attL 516350:516364|attR 539532:539546

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
516350:516364	attL	NA	NA	NA	NA
WP_093664621.1\|518330_519511_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	4.2e-40	38.0
WP_077340194.1\|519674_520007_+	hypothetical protein	NA	NA	NA	NA
WP_077340196.1\|519999_521043_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_077340198.1\|521177_521534_+	hypothetical protein	NA	NA	NA	NA
WP_162274469.1\|521637_521934_-\|transposase	transposase	NA	NA	NA	NA
WP_162274470.1\|522018_522348_+	recombinase family protein	A0A1B0V7I5	Salmonella_phage	9.4e-14	54.3
WP_077340202.1\|522497_523268_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	6.8e-47	41.8
WP_077340204.1\|523267_524521_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	1.2e-13	31.9
WP_077340206.1\|524945_525698_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.3e-17	27.6
WP_143028156.1\|525694_526930_+	hypothetical protein	NA	NA	NA	NA
WP_143028157.1\|527510_527915_-	hypothetical protein	NA	NA	NA	NA
WP_077340210.1\|529119_530349_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_093664625.1\|530615_531793_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	4.2e-40	37.3
539532:539546	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019605

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection