CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019645	Helicobacter bilis strain AAQJH chromosome, complete genome	3 crisprs	WYL,cas4,cas3	0	1	0	0

1. NZ_CP019645

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019645_1

• CRISPR_ID: NZ_CP019645_1
• CRISPR_location: 448154-448264
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP019645_1

Consensus_repeat	Method
GACATCTTCGCATAAAACATACATGATAATAGACATAATAC	CRISPRCasFinder

spacers of NZ_CP019645_1

>1.1|448195|29|NZ_CP019645|CRISPRCasFinder
TACTGCTTTTGTATTTATGCCTATTTGCT

CRISPR arrays and Neighbor proteins around NZ_CP019645_1

CRISPR arrays

The CRISPR arrays of NZ_CP019645_1

>merge|NZ_CP019645|1|448154-448264|CRISPRCasFinder
GACATCTTCGCATAAAACATACATGATAATAGACATAATACTACTGCTTTTGTATTTATGCCTATTTGCTGACATCTTCGCATAAAACATACATGAAAATAGACATAATAC

>NZ_CP019645|1|1|448154-448264|CRISPRCasFinder
GACATCTTCGCATAAAACATACATGATAATAGACATAATAC	TACTGCTTTTGTATTTATGCCTATTTGCT
GACATCTTCGCATAAAACATACATGAAAATAGACATAATAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019645.1|WP_005219639.1|446120_446408_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|197478
NZ_CP019645.1|WP_077388189.1|442039_443317_+|divergent-polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|200562
NZ_CP019645.1|WP_004087570.1|445821_446130_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388197.1|462282_464526_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NZ_CP019645.1|WP_004089046.1|454503_454821_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388190.1|443432_444719_+|homoserine-dehydrogenase	unknown	unknown	gnl|CDD|235783
NZ_CP019645.1|WP_004087480.1|437787_438063_+|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl|CDD|234822
NZ_CP019645.1|WP_174566005.1|449814_454464_+|hypothetical-protein	unknown	unknown	gnl|CDD|376228
NZ_CP019645.1|WP_005219796.1|459864_461028_+|DUF4043-family-protein	unknown	unknown	gnl|CDD|372532
NZ_CP019645.1|WP_077388196.1|461344_462010_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077390041.1|438232_439903_+|arginine--tRNA-ligase	unknown	unknown	gnl|CDD|234964
NZ_CP019645.1|WP_005219726.1|441171_441450_+|DUF493-domain-containing-protein	unknown	unknown	gnl|CDD|377327
NZ_CP019645.1|WP_077388198.1|464607_465903_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl|CDD|223694
NZ_CP019645.1|WP_005219727.1|441462_442002_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388192.1|455060_455309_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388195.1|456820_457207_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388193.1|455286_455865_-|dCTP-deaminase	unknown	unknown	gnl|CDD|274062
NZ_CP019645.1|WP_077388191.1|444718_445651_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077390045.1|458326_459412_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388188.1|440098_441016_+|hypothetical-protein	unknown	unknown	gnl|CDD|276807

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP019645.1|WP_005219639.1|446120_446408_-|tetratricopeptide-repeat-protein	gnl|CDD|197478	smart00028, TPR, Tetratricopeptide repeats. Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.	0.00243307
NZ_CP019645.1|WP_077388189.1|442039_443317_+|divergent-polysaccharide-deacetylase-family-protein	gnl|CDD|200562	cd10936, CE4_DAC2, Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria. This family contains an uncharacterized protein BH1492 from Bacillus halodurans, an uncharacterized protein ATU2773 from Agrobacterium tumefaciens C58, and other bacterial hypothetical proteins. Although their functions are still unknown, structural superposition and sequence comparison suggest that BH1492 and ATU2773 might be divergently related to the 7-stranded barrel catalytic domain of polysaccharide deacetylases (DACs) from the carbohydrate esterase 4 (CE4) superfamily, which remove N-linked acetyl groups from cell wall polysaccharides. This family is designated as DAC family 2, a divergent DAC family.	6.52628e-63
NZ_CP019645.1|WP_077388197.1|462282_464526_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	5.13557e-07
NZ_CP019645.1|WP_005219796.1|459864_461028_+|DUF4043-family-protein	gnl|CDD|372532	pfam13252, DUF4043, Protein of unknown function (DUF4043). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 369 and 424 amino acids in length. There is a single completely conserved residue G that may be functionally important.	3.91208e-08
NZ_CP019645.1|WP_004087480.1|437787_438063_+|twin-arginine-translocase-TatA/TatE-family-subunit	gnl|CDD|234822	PRK00720, tatA, twin-arginine translocase TatA/TatE family subunit.	3.34167e-19
NZ_CP019645.1|WP_174566005.1|449814_454464_+|hypothetical-protein	gnl|CDD|376228	pfam18809, PBECR1, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine and threonine residues.	1.38415e-34
NZ_CP019645.1|WP_077388190.1|443432_444719_+|homoserine-dehydrogenase	gnl|CDD|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NZ_CP019645.1|WP_077390041.1|438232_439903_+|arginine--tRNA-ligase	gnl|CDD|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	4.35437e-149
NZ_CP019645.1|WP_005219726.1|441171_441450_+|DUF493-domain-containing-protein	gnl|CDD|377327	pfam04359, DUF493, Protein of unknown function (DUF493). This domain is likely to act in a regulatory capacity like pfam01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).	2.2149e-13
NZ_CP019645.1|WP_077388198.1|464607_465903_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl|CDD|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	7.58278e-119
NZ_CP019645.1|WP_077388193.1|455286_455865_-|dCTP-deaminase	gnl|CDD|274062	TIGR02274, Probable_deoxycytidine_triphosphate_deaminase, deoxycytidine triphosphate deaminase. Members of this family include the Escherichia coli monofunctional deoxycytidine triphosphate deaminase (dCTP deaminase) and a Methanocaldococcus jannaschii bifunctional dCTP deaminase (3.5.4.13)/dUTP diphosphatase (EC 3.6.1.23), which has the EC number 3.5.4.30 for the overall operation. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	4.32832e-25
NZ_CP019645.1|WP_077388188.1|440098_441016_+|hypothetical-protein	gnl|CDD|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	2.82337e-05

Protein sequences

>NZ_CP019645.1|WP_005219639.1|446120_446408_-|tetratricopeptide-repeat-protein
MSRKLLSLGYIYEMIGRHEEALAFFEQVLEKDSKTLSTELIKEAHLGIKANEMALKFKRDKSLITKNLDMKLMQEKIAIFKENPKNLTGWFSQWN
>NZ_CP019645.1|WP_004087570.1|445821_446130_-|hypothetical-protein
MELKDVVLQTLSEIENSVDEKGFKDIRLGVNTGETEFLQSFKERIFVLFEGLKQDDLWLESAEDTQNQIQAKLDLILGFLQFQLALLDARLEVLDKRNFEGE
>NZ_CP019645.1|WP_077388191.1|444718_445651_+|hypothetical-protein
MPCIYFLLFSLSILFVACDSDKKDTNIFMQTSSNLAYTTEKLDSNSLTLKEIPKEVNDYTALYNAYLQRKSKGKKSSIKEAKIIDKTFVRLRHTYKNDKDIMQILESFSCILPDCSATKIKDTYFYPDMNIQEAFFAIIADKKTEIFTHFDIIKDYSYVLKDMQTTSIDLQAQYDKITPFQTLKFTWDTQSLEIALTPKEEICKPYIYTYRTIFIQDSDGVRVGPQGERLSVFSYPTQLVDFVAKSCACARFYRYIPELTQAEKQVAKNALAPDKKHCENLSIERKALWDTYMQDSRVIRILQHEQSLYP
>NZ_CP019645.1|WP_077388190.1|443432_444719_+|homoserine-dehydrogenase
MKTINVAIIGVGVVGSSVIEILQQNRDIIQARTGAFIIPKIGIARNIHNKNVNIPLSTNIDDALNDPEIDIIVELMGGVELPYKIALKALANKKGFVTANKAMLAYHRHELELKGSESSIGFEASVCGGIPIIKALRDGLCANHILSIRGIMNGTSNYILTQMSNNNTDFATALTQAQNLGYAEADPTLDINGSDSAHKLLILASLAYGIHAKMEDIIVEGIEDVSLEDIRFACEHDYSVKLLGIAKKQENALELRVHLCMIPKDSMLAKTDGAMNAISVIGDKVGESVYYGAGAGGSETASSVVSDIIEIVRSKTAPMLGYVAGFQHSLEQNMVLLPKDKIISRYYVRLQVDDKPGVLAHIAEVLATHNISIQSLIQRKPKDLDTHSALLLLATHTCSEVQIKKALESLENLKEVSKKPYMIRIESL
>NZ_CP019645.1|WP_077388189.1|442039_443317_+|divergent-polysaccharide-deacetylase-family-protein
MNDMQSHKKKSIIIYLVFIITAFILSVFSWYYIEKDSKNKDINPLSLDSQTMQHLQINEAPPIHIQTHIESTTANKNPKDSKQLDSASFNNEGNHISTQIDSNNCHNAKSTFCHDLQSQASNIETKQNLDSNNCHFEYSKQSNTDSKNDISPVTSNKESITHPCRNDKFPNSIKNSDKTTTTYTKNLQRFYKKPKVVIIIDDLANKKDIKNFQSLHLKLTLSLFPKQFFSKNNPDIAKTLEFYMIHLPLEAHNFEQQGVINLRIGDSLQTIESHIAQIKKDFPKLAYINNHTGSRYTESREDMQKLLQVLARHKISFVDSLTTSKSVAGKLLKEQHKIHIARNVFLDNETNVASIAKQLNTALRIADKQGYVIAIGHPKQATYQVLKEYKEILLNDYEMLYINELDLLLQKHNISDTKTPLPLLE
>NZ_CP019645.1|WP_005219727.1|441462_442002_+|hypothetical-protein
MIAKILAGFYLLLVGVCIGGIIVTNISESIIMSIDIVFRNNDFSTTLITKYDQGIILAPILLQVGYMLVFAAIFMLFYETMSYRFQKSTFFVWACNVLNAILMFLFGLFYAPNIAKIFNEEPKVMASPDSESFLNQSELILKLLLATLLIAFFARIILMYKRGVTELRLTKQKDDKKPQ
>NZ_CP019645.1|WP_005219726.1|441171_441450_+|DUF493-domain-containing-protein
MNHQHSPINIDIKPQIDYPCIWRYRVIGFSKEIVLEAIEKVFMGKADIAPVEHISSHGKYVALNCSIEVKDDSERLAYFDGLTKQHGIIMVI
>NZ_CP019645.1|WP_077388188.1|440098_441016_+|hypothetical-protein
MIIGEEYMKKVSVNIFAFLMALLLIACAGNSNIDKDDDKEGVAEEIAALHAEMNKLHGKTSGYYANVAIADEEYDKAYGLHYKECKLGSVIECLNAYYIGEERALSNYDSAEFAEDLTKSIVKNGKACKKGESLGCVNLFFAFEALDDNNEFLKQIIAPSLKHHNDEMIVDKALNLTKKECERDDATSCFFHARMLRIIDHYADVDYFVTKGLDLGYAIAPFVRLPMQSPQTIDYFKRSCALNEAMSCRYVAYWFDKYENNKNLAKSFYQKSCKLGLQVACDEMGKTSKAAQQVDEVGAPVIKRR
>NZ_CP019645.1|WP_077390041.1|438232_439903_+|arginine--tRNA-ligase
MIESKTESKKDSNSSQEKINLIIALEHPKDKRHGHFATPLCFTLTKILRTNPKVLAQSLQDFFMQYDLDSNSTKPFKKIFSSIEALNGYLNLTLTHSFLTYMLEVALQSPKDFAKGECKNTKILLEYVSANPTGPLHIGHARGAIFGSVLQRIGKRLGYDIKGEYYVNDAGSQIDMLALSVYNSAAKILNLESLSGEVYKGEYIDSVAQDAIKHFGESFFRTADSQKTDILQKIGLYAKDMMLEVIKENLASLSIDFDYFVSEKELYTRFDDTMKTLETHNALLHQDGAIWLQSTLKGDEKDRVLVRDNGMPTYMAGDIIYHKDKFDRDYNHYINIWGADHHGYIARIKASIDFLGFDSKNLEVLLAQMVSLLKDGQPYKMSKRAGNFILIQDVVNDIGADSLKFVFLSKSLDTHLEFDVQDLSKEDSSNPVFYINYANARIHTLLEKSSLSLEDINKTDLSTLLDSNDSLGQDSMQLILQSLGLFYVLNQSYEERALQKLCEYLKNLAKSFHTFYNAHRILQTEHEAGILKIFLLVSLSLTTGFNMLGINIKTKM
>NZ_CP019645.1|WP_004087480.1|437787_438063_+|twin-arginine-translocase-TatA/TatE-family-subunit
MMGSMSIWHWLVVLLVIVLLFGAKKIPELAKGLGSGIKTFKKEMEDDDDKKVEQTSSEAKPQQKSEKKPEVIEAQVIESSPTIQQKQTEKI
>NZ_CP019645.1|WP_174566005.1|449814_454464_+|hypothetical-protein
MRNYEKSSSDLKKFRANKHLDNIKDNIDNAIKNALDSKVIKDEIAIREFGENYPQFYHKPQEAISHLLETRSGQVQAAMHKKGVGDIDFIWGDSEKGLQHILERRTQQYGEEKALKFVKDLPRMIDEAVVFESLKHKIILKTPKATIVLGKRENNQFVLSGFYDRKNKKLGISSPSYEANFTDKSGFQHNDGGVLLSNRPNPTQKTLTRQEADELFSNFQQANKNYAQIKESLNDKFAKALTKGMNKKDLDSRLTIEQWKQRVLDTQWGDSIKGLENTIFKNFNPRMQKHTQMLTILRALDRNVKLNDDTFPIDFTKILSDIENLEKLTLHPEIYPILDTFKSYAKSYQFAQEISKAKALENQVGSGALATTLEGRIKVFLTNRLFKKLFAFIPYIGDNAAITKALQSAIKDLKYPSEITLETLKVLNKADLDKGFKPIKDKENKPRFEYKANTPLSDKELQSQIRGNTQILTPKDTSEIEAIASNPLIQNMERQAKYNEELTQKISQFEANKENIQQDILNNLVVATQEIKQNTELLKQLAQQLTHNNPIHTPNKSIIKAEANNETYFITTDKNNITAIEKQELQLAQPKTYDELMQRDKNENATLESYRDQYADIAEIKEAQAQKQLLLEYKPEVAKASETIEKGVDEKIKVLPKINLNTAKRGEIKEYLSQILKPILDKPLRNTQGLQAYLNNASIDKMISDKAITKSVENGFSKQEHLEAVADIERLFSISKEAIAHSHRENNPGVIIHRLNAPFKESNALITTKESLDKNKNRIYSVELELTPRFNTSTRPTDIEANKGGFNSLNGQGGQNLPTIAKTDTDIIPQKLTERIKNDLDSNDYAEMLKSLKQLENKQAEIDTFTNEANLIRNTLEKQETEKYEKIVSPLFDKYPIMKEFYNERDINTHIYFKRFKNEFLERYNTQYDFFTLDEKAFLAKYPNFTQQDYKEATTQNLKALKDKNVSINEYVSFAKEYMDIVNNPVFEKMAKEIDSVDKKYWDTHFEMSEQRDSKVNEIIAILKKDIDSIDIANKADVSIDNFHKLGRYLAFMKQPEFGFANKLTFTKTGFFGKFLEQTDIKQRELLGELLSVEKLLEKEGKANRVLQDRLFTIFRLMRGEELLDREIKDVPLARELIEKQLNIKPIKEFGTNYAEHYHSGETAIQKLINEAQAHKESGAKGEYKGQVAGAFHRKELGDIDLVWGEVTGKGKEAKGWGLAKIIEKHGDEFSSFSGNTEEQKLINGINEIIQNGKLLTENGVNTLYLQKDNKVFLVGLSKGWDKKGENQWIITSYEANNLSPDILEKIGANKTISADESLNALQTFNATDNNIIPQTSQEIVKNNNIKESANMLESKVKMQGQDLDLFSTFIENGRIREDVLNSYAKKMPDMLNQQEFLAQIPHKDKQGYSTIQTPIGNIKINLNHAWNHLNKGNTYKKDRSLYSGAFLDTLADPLFIVKQEYTPNPKVSANAREMQNSKLVQTRDDESIAQDSYVFFKPYKIKDKFNYMVGYALDIQGNIINTTFIPMSNRDFGRIKKMFSSQVLYAKL
>NZ_CP019645.1|WP_004089046.1|454503_454821_+|hypothetical-protein
MPEGMPRDDIKNLFQHFKGKIDERERKLYSKLIDDTKAHPDITLELEREGHARKGYIKAYQHKETHDLYYMYITQDNDRIDITGMPMTDLKDVIAQVRNCVKVVS
>NZ_CP019645.1|WP_077388192.1|455060_455309_-|hypothetical-protein
MHDSKINKLITIIQCTIQETMTKQEHLTPTLNDIYDSFNLLGLKLERHENNSSEILKMLKNKEHTNWDTFIIKLLQVYKSQR
>NZ_CP019645.1|WP_077388193.1|455286_455865_-|dCTP-deaminase
MILATSELEKIRHNITALNDNNIRGSSIDLSIDDKAFIKKNDDIIDLFQVDSVEDLCADIYDEVDLAKGYELKPQSYLYSKSVETITMPNTMCGIVLPRSSFARIGLILPISSYVNPGYNGNLPIVIFNASNSIIKIPPYIRIMQLLFCELKGEAIPYGSLNDSKYQNENELSIPKFNDKEIGEILARLKNK
>NZ_CP019645.1|WP_077388195.1|456820_457207_+|hypothetical-protein
MNTKTIIAFAALALFLYIQLNAKLDDIILGIDSNASVLVSLRDRQKMQDADGKIVLIKNNIKALEDTECKKCHVLNENLLLPIENKHISYETFLRFVREGGLYMPSFSPESISETKIQQIYTKLYNSK
>NZ_CP019645.1|WP_077390045.1|458326_459412_+|hypothetical-protein
MRNRQSKEMPGSNHYDYEYSKRGFNIKLEKAQEIDITKDLAQEAAVAQVVKGGVLALCSLHYCKRYKALREFNDICEVKAHIPTDMQEQEINPSIKRFNNQIAHKQLKDSQNRYKEGYQPKITHYLKLDLIDESIDRYYRDYMNLYSQLSEESKLKFGFVELTESKEAWFYSPHICKEKTQGKRTPPSEEEAKKIIENYTKQREIKKKEFESKEENVNKRFYLRQVNLSRTDLTLKKYAFQKGDYVFSDSNHKIFIASYDGEGFRHTIKTQYFYVDSIATGEFSIQPYEVEEWDGEESISVIYYRLLITHRVTLKHKVDKDFLQKEIGKLVTQLAIDGKNHGLPQNTIDKNLDNLIQNGML
>NZ_CP019645.1|WP_005219796.1|459864_461028_+|DUF4043-family-protein
MSYTLTDIINNPNIGIEIGKEIESMSWIKSPFEPLVGQGSDRGIRSYQIANKQPFRPRLKARLTGTGVQDNEEFQTNYDEMEILNQTIYPKISGNGLLSPVFHYSEMQFIDFEKEAKDSLATWMMDTRDKQFIAALTNDLTNCVVADATNGYKDTTAETSVKNASKKIQKGDTISVKAIRRAIFLARTGIDYKNREIFPLKPIRAQSMSNGGISTMHYSYIIMLDSYGIQQLKNDEEWRDMQKYAGERGPSNNLFMGLVGMIDGCPVLDFGVWSEAAAGLCNSEVKDKDFLRFLNKDNTHNKIVKPSDYADAQPVSIGFLIGASALLIAGNLSPRMYVEQKDAGRKIAVGMDRVMAIAKARFGEDDNGLLKYSGQDFATIGLFYSKE
>NZ_CP019645.1|WP_077388196.1|461344_462010_+|hypothetical-protein
MALRRKTPQDKDIQQLQIKELQEIVTNLTKEIQELKEQQKSEGNLGEVVNTLIQEIKGLQDFTFSLQKTLKEHAENSQYLLSKINKTEGIADKNAGDIYNLKIKEGLHSDLLDRAKPIIEIADPLSTVAFRIQKLETSLQKVKDFNPQELKEREEVNTNCITDLQTDFLLHGQMLADLRLEIEKVKKLQALHDKQIHALKHEVSKSVWEKLFKWRLSFGRF
>NZ_CP019645.1|WP_077388197.1|462282_464526_+|hypothetical-protein
MNDTQEFQRTTIAEVTQNTQADSSPDESQKMGEANALDSKTQDTQTESTQAQSITEQLHNAMQEVDKQIAQEVKDKKADLANPINPPQSITQADKDRLEKVYTDMQNALTQNANFIIKTDLSLRGITELIAIMRILNDFYLYHVELLKDNKESIEVAVIDIEAMNKRFSEMVRLANGYIMQALKEIDNANATSLALRNEIEALHDACQLDLADTKNTMQKVTQTYEKLQLIEHNIGNLEQAIEEFERLTENNESLLNDMRDFLNTELNNAIAALMLKKEEYERDLQDNYTGLQEAFNKLLAQLQTQAQDFIVESNQIKTDTINEINSVANNRLQEVKALDTEVNARLTALRDESLQALDTKKTEGLLELETKANELATECNTKKELYLQAITDLSEKSLESITAKGDEKKAELETHTQNFIQEAENKKQEITNTLDSKKAELEQAKENGLNEIRQEASTHETQLQTKLEESLESIIQKGEEKIQEIENNTTQANTNLDSKLQEIETKTQQVENNVNTMIQEHNTHLNSFATQSQEALNAIKTEGMQEIRTEAQRLLEQIKNNTTTLDQNVRQEYETWLLNLQNKGQEAQTLIQEGINTTIPNALQNSQTELETKKEEHLQSIDSQKESSLESINELTEQTISQLKSTFSFLMSDLTHENFTQTTTWNKPQNVKRVFVNVLGGTGANNATTRGTPSSFGSFVTAQGGVGNAGGNGQFGEMKFSIVDIPESETSINVSIGAGGSVDIFY
>NZ_CP019645.1|WP_077388198.1|464607_465903_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MKKLHVVSLGCSKNLVDSEVMLGKLQDYEITQDLGSADVIIINTCGFIEAAKKESLGHIFEALEGRKKGALLVASGCLVARYAKEIKEMIPEIDILTGVSDYDKIDTMIKDKKGVMNDSVYLQKDEKRVITGSQIHAYVKISEGCNQQCSFCAIPNFKGKLQSRSIDSILNEVESLAKEGYKDISFIAQDTSSFLRDKGVNDGLLKLINAIDAQGAIKSARILYLYPSSTDIALLDGIANSQIFQNYYDMPIQHSAKSVLSHMQRSHKDMMKLLEYMKKIPNSFVRSSVIVGYPTETEDDFNALCEFLESFRFDRLNVFEYSKEEDTEAGKLEEIPRKIRTQRINKVKKILAKIDKQHFSAMLDTHIPCIIEGKSMLSPHFYSARDMRWAKDIDGEILINDGEYSGPGYYNVHITQTKDNILIGSIKNRFE

Crispr_ID: NZ_CP019645_2

• CRISPR_ID: NZ_CP019645_2
• CRISPR_location: 1541698-1541811
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP019645_2

Consensus_repeat	Method
TTAAAACAAGATATAGCGGAGTTAAGA	CRISPRCasFinder

spacers of NZ_CP019645_2

>2.1|1541725|60|NZ_CP019645|CRISPRCasFinder
GAAGAAGTTCATGCAGAATTATCTAAAATGGATTCTAAAATTATGCAATTTAGAGCAGAA

CRISPR arrays and Neighbor proteins around NZ_CP019645_2

CRISPR arrays

The CRISPR arrays of NZ_CP019645_2

>merge|NZ_CP019645|2|1541698-1541811|CRISPRCasFinder
TTAAAACAAGACATAGCGGAGTTAAGAGAAGAAGTTCATGCAGAATTATCTAAAATGGATTCTAAAATTATGCAATTTAGAGCAGAATTAAAGCAAGATAATGCCAACTTAAAA

>NZ_CP019645|2|2|1541698-1541811|CRISPRCasFinder
TTAAAACAAGACATAGCGGAGTTAAGA	GAAGAAGTTCATGCAGAATTATCTAAAATGGATTCTAAAATTATGCAATTTAGAGCAGAA
TTAAAGCAAGATAATGCCAACTTAAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019645.1|WP_077388831.1|1538682_1538853_+|site-specific-DNA-methyltransferase	unknown	unknown	gnl|CDD|334588
NZ_CP019645.1|WP_077388841.1|1549588_1552204_-|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319847
NZ_CP019645.1|WP_077388843.1|1554517_1555033_-|hypothetical-protein	unknown	unknown	gnl|CDD|376231
NZ_CP019645.1|WP_077388828.1|1536199_1536757_+|hypothetical-protein	unknown	unknown	gnl|CDD|334588
NZ_CP019645.1|WP_077388833.1|1539696_1540284_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_155761474.1|1523438_1523597_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388826.1|1521750_1522233_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_167619991.1|1538922_1539393_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388839.1|1547226_1548405_-|cation:proton-antiporter	unknown	unknown	gnl|CDD|366411
NZ_CP019645.1|WP_167619990.1|1536923_1537805_+|site-specific-DNA-methyltransferase	unknown	unknown	gnl|CDD|334588
NZ_CP019645.1|WP_077388835.1|1541935_1542208_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388836.1|1542274_1543768_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388827.1|1524654_1535820_-|hypothetical-protein	unknown	unknown	gnl|CDD|376182
NZ_CP019645.1|WP_077388842.1|1552556_1553801_-|alpha-1,3-fucosyltransferase	unknown	unknown	gnl|CDD|375497
NZ_CP019645.1|WP_077388830.1|1537874_1538525_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_005218673.1|1540678_1541314_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388838.1|1544933_1546916_-|ferrous-iron-transport-protein-B	unknown	unknown	gnl|CDD|223447
NZ_CP019645.1|WP_077388837.1|1544341_1544932_-|ribonuclease-HII	unknown	unknown	gnl|CDD|260003
NZ_CP019645.1|WP_004089118.1|1549182_1549470_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077388840.1|1548425_1549166_-|hypothetical-protein	unknown	unknown	gnl|CDD|187714

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP019645.1|WP_077388843.1|1554517_1555033_-|hypothetical-protein	gnl|CDD|376231	pfam18812, PBECR3, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine and threonine residues.	8.11099e-11
NZ_CP019645.1|WP_077388831.1|1538682_1538853_+|site-specific-DNA-methyltransferase	gnl|CDD|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	7.32211e-17
NZ_CP019645.1|WP_077388839.1|1547226_1548405_-|cation:proton-antiporter	gnl|CDD|366411	pfam00999, Na_H_Exchanger, Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.	3.8776e-28
NZ_CP019645.1|WP_077388828.1|1536199_1536757_+|hypothetical-protein	gnl|CDD|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	0.00366901
NZ_CP019645.1|WP_077388838.1|1544933_1546916_-|ferrous-iron-transport-protein-B	gnl|CDD|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NZ_CP019645.1|WP_077388827.1|1524654_1535820_-|hypothetical-protein	gnl|CDD|376182	pfam18760, ART-PolyVal, ADP-Ribosyltransferase in polyvalent proteins. A family of ADP-Ribosyltransferases found in polyvalent proteins of phages and conjugative elements. These are in turn related to the Tox-ART-HYD2 group of ADP-Ribosyltransferases that are seen in polymorphic toxin systems and in toxin-antitoxin systems. These are predicted to modify host proteins.	1.93954e-25
NZ_CP019645.1|WP_077388841.1|1549588_1552204_-|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319847	cd07548, P-type_ATPase-Cd_Zn_Co_like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell. Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP019645.1|WP_077388837.1|1544341_1544932_-|ribonuclease-HII	gnl|CDD|260003	cd07182, RNase_HII_bacteria_HII_like, Bacterial Ribonuclease HII-like. This family includes mostly bacterial type 2 RNases H, with some eukaryotic members. Bacterial RNase HII has a role in primer removal based on its involvement in ribonucleotide-specific catalytic activity in the presence of RNA/DNA hybrid substrates. Several bacteria, such as Bacillus subtilis, have two different type II RNases H, RNases HII and HIII; double deletion of these leads to cellular lethality. It appears that type I and type II RNases H also have overlapping functions in cells, as over-expression of Escherichia coli RNase HII can complement an RNase HI deletion phenotype. In Leishmania mitochondria, of the four distinct RNase H genes (H1, HIIA, HIIB, HIIC), HIIC is essential for the survival of the parasite and thus can be a potential target for anti-leishmanial chemotherapy. Ribonuclease H (RNase H) is classified into two families, type I (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type II (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H endonucleolytically hydrolyzes an RNA strand when it is annealed to a complementary DNA strand in the presence of divalent cations, in DNA replication and repair.	4.90728e-63
NZ_CP019645.1|WP_077388842.1|1552556_1553801_-|alpha-1,3-fucosyltransferase	gnl|CDD|375497	pfam18025, FucT_N, Alpha-(1,3)-fucosyltransferase FucT N-terminal domain. This is the N-terminal domain of the alpha chain found in Helicobacter pylori Fucosyltransferase protein which is involved in the production of Lewis x trisaccharide, a major component of lipopolysaccharide. The N-terminal domain contains the catalyst base, Glu-95 which is equivalent to the Asp-100 of other members of the glycosyltransferases-B family. The domain contains the pocket where LacNAc binds. The domain is composed of 2-10 heptad repeats and a conserved N-terminal alpha-beta-alpha motif which has little sequence similarity to the conserved N-terminal motif in other glycosyltransferases.	4.17303e-24
NZ_CP019645.1|WP_167619990.1|1536923_1537805_+|site-specific-DNA-methyltransferase	gnl|CDD|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	0.000968128
NZ_CP019645.1|WP_077388840.1|1548425_1549166_-|hypothetical-protein	gnl|CDD|187714	cd08645, FMT_core_GART, Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART). Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein but in most eukaryotes it is the C-terminal portion of a large multifunctional protein which also contains GAR synthetase and aminoimidazole ribonucleotide synthetase activities.	1.54568e-62

Protein sequences

>NZ_CP019645.1|WP_005218673.1|1540678_1541314_-|hypothetical-protein
MTKSEKELLKKEVRTYYEAHYEDIKQVAKLFKVNERTLYNWIQTEKWEKGKLVKNTELKAITNKLLNDKDVLDNIGIAKNAIKHNMRENMQNLYSIYEERILDNTADELLLKAMSETFIHTQITKTALIAQSEFNRLASLSVKSSVPNPKVIQAAKDVVSIFTDMKKCLYPNQDNTQVNIKAILNNGVISKEQIAGLTDEQIREYLGNDNL
>NZ_CP019645.1|WP_077388833.1|1539696_1540284_-|hypothetical-protein
MASLTDLIQNMIQANETTQQELQSTKQEFNDLKSYVDTQVSDENILDIMHEQFIKDEYFTSESFYNDIGQALINKYGLGNLINLDRNQVNEAVKEYLAKNLDTKAVTEYIMQNYTGEIRDAMIRRIRIESKSILDNYDFSLQVLPRLEVLFKEFVKNYELTSYLMKSTAQLFVAQESNLAFMLEYIVAKELLHNP
>NZ_CP019645.1|WP_167619991.1|1538922_1539393_+|hypothetical-protein
MTIIVTSPPYFNILKHNSKGLRADKSHKGFRNGARDGVVTYNVDSKENLENCEDYESFLKALSGIFNECKRVLKNKKYLSIVISDFTINKQEVNVTGNIIAMMIDLGFKFVGNVALLQNNKPLYPFGYPYAYKINHHNQNILNFMKENKSPINSVD
>NZ_CP019645.1|WP_077388831.1|1538682_1538853_+|site-specific-DNA-methyltransferase
MQKLISLFTKKHMKVLDPFCGSGTTLLAASLLERQSIGYDLNLEYRDLALQRLQKN
>NZ_CP019645.1|WP_077388830.1|1537874_1538525_+|hypothetical-protein
MQVLKENALVSLDDMLNVVYKNFPNGLTPDENSILKSLKKFATKSSNAWVYSPNAIESKNATQHTLYISYLAKIGKKLGFDIFIGKREQRENIDNKKLSDYANIFELNFIKDDFTRQRALYIDILFVKNKSIHYAFEIENSTNIIEALHRNSVLESSIPKFIVIPNNREEELLGKKEPLFIESIQKNHWQYLLYSDIDKLVNVKYPRLEQFAKDIV
>NZ_CP019645.1|WP_167619990.1|1536923_1537805_+|site-specific-DNA-methyltransferase
MEQNPLLLFERNCFKKQGVKTALLASNKYVDKSLLCKEVSNANKQKDSKNFALKYGVVNILKLEDYVNEKSVDFIITDPPYGGLVQYLDLSYLWLLWLKVYDKKYGNIDFASEITISKKCDIKAYEVRFTKSLKQLHRVLKDDGKMVITFHNKDIAIWNSFMRSLKNAGFIIQKVIHQKNRRSGESVVANPYGTSGTDFYLRCIKNPHTQISTEIELQNLSQKIVEIAINAIALRNEPTPYEILFDAILAHITSSGFIFSDDCDGDIKTALNKHINKIFIIRQDKETKAGNLW
>NZ_CP019645.1|WP_077388828.1|1536199_1536757_+|hypothetical-protein
MKYRGKKPHNVWASYIDTYTPKDGVFLVPFCGSGMSALESLRLKRKTLAFDINPLSSFLLKIYTTHFDFNAFKKEALKIIDNVRKDSIYQKLWAYDGEFHNFKYYDGEIYEICKVDKNIYYEATQKDLKSLKFADSINLQDLGLNFIDEPFLDSDSFSANFIKQIGGNNFKYMDKTQFNYSIFNL
>NZ_CP019645.1|WP_077388827.1|1524654_1535820_-|hypothetical-protein
MSEARKDIETIQREVIESNPNFMPTRQIDDFDNEATYKMEVEFDKLGMQEFQRKIESGEIQLDKPTQKTLENAYSQYNHLLQKRELLEKDLQSFKAFDDNNILKTNSTLIAQTQRVLHQIQDDISFTKEAIKDIESELSTSNKALMLLNTHAETKKEIHAFSNLLVPTQTQTKPSFATNLMKQDTQGLIPYNSTQANNALIPYNTPQDTKLLAYNETKLLEYKETLHALQKLDKSFKDFMSMPFSIIVDSKGNALPLTSQAIKNFIFHNLYKEFLNTTKALNKPLAQLDFKPLSNEIKALPYKANANLKAHLRDINAKTNDFLDSMQEIKNTTKEIKLLPYNKPSENKAVEVDRFRNVLVSKPLQHESFVRQDLRKRVWQENENYDISNPKLFSYKFLDNKEIINMPDFALSDRGRAIKKVVAEEPKQRELIEQINAGQTEKFSEFMDKEREALQALKVNLQHDETTAQRFIDMANMFKDNELKREYFKEMLNVADTIRHHTNTTYPMFEKAYKDLLKEMFPTKPKDIHFTDKKGKEHILTKEVQQQWLDTFNLKSLDDTFIPSIPQEVREAIGKDIKVNFKDLLKLVENGREKYIPQIRETFSKPEAAFIDEQNDLIFARTMTDNLFFVNVSRDYGENFLNVTLSPKKHNTLLNKLKNAKEVFIDKVSPELRDSSAHKASTDFLSSTSRDTQNPTTKQEISKDIESKSTQEPVTQKETQENTQAINQSEGIREQNQHLHLESLDTTRFFETINNMQGKNLSKKDKIQLFDSFTSALQSRQDLIIDEIERILKHANKSGDRKYKDFSDLDEYAMKEIFFKLKNRDLYDDYESILKALKANKDIDWDKSIFKEFQNTEKGIALSNNKISSGVAEDFAKSLKEWELDNNHIVNKFKDTIQSQKIKDTHANTKQNSNTTNHTDKETSTKESYTDNQHEATQRENGADTEWITTRTSNNPQENKDTETTLTRDNGISDEYSPSSKEMAQSGNEKTHEKRDIRDDSSHSSSDIEANANISRDTQGHNARIRPDETDNKRYKHDGNDDRTNSRTRIHRNVSLKKKGKKDSNTNIESKVATQDIDTQSTPQVKPKKLTDKEVIDNFLKEYDNHEYGSKDISLIKNIDKPENLMYIVKAIKDFNEARTLQDDILKIDSKAIADAGVLSLEERQQLGRGMGDLLPTLKEAFHYLHKAPYPAEIYKISNIKKRLKEVKKAYNLVQEKGLHRFDYPQTNKDVSLNAQHDKEIPANTHEKETPKTTKEIIKEAKASGKSVRETQELIDKNKATETFTDSYGKTHEIPKEIAQAWKNTFNLKSLDEAYIPSFTPEVKQALDSILQGEDIKLSAGSLVKLIKENRLKYLDRIKPTLEQPQRIILQNDGALIFARDFGEEKYFTSVARNNEGEWIIRSNAPKSKNGLNNKISAGGKEIYNSQATNQINAHSPYDDIAKSNIKLDNDIIPQQKPKEKQSPKELENIESDSNPAGILNPEELATLNKEFKLGEIQDLKGQKALYDANIESLSLLDDILKSGRVATDDEKRILSNFRGFGKASNELYQVIKEKGERLDSLNKLLESLSESVGAKIDADYLFRRAGDAYYTPTPIVESMVKLAKDLGLNNNHVILEPSSGSGRFLGQFHSNANVVGIELDPFTAKLSQTIYPYFKIDNAGFQNSKFAKDDFYDLVIGNPPYSNFTIRDDNFSASAHNYFMKRGIDKLRVGGISIQIVTKSFMDSSNDLVRKEIAKNAKFLGGVRLPNNAFKDASVTTDILVFKKVSAAEAKKLDNSWIETTELNGIPVSKYFVDNPQNVLGEMKVGKGQFGDIVHVINKEGIDFSNFDLMPYLNKKYDFDTLRLKDNNTHSLKDLESEVKTTQDITDSQMGAVRYDKEQDKFIKNDGGSDDELDLKEYLQSLEVTWKPETIEKRIAEYKELAPKISELQSTLKSLQKAELDSEASNETISALRQKLNSDYEAVVGKNGSFYTKDKKVSPRFKLFEMVDDTSFEIFALEKAPLVKNNKVVGAERADIFTKRISYPYVRPQSADNLADAMHISLNETGYNDYQRIADLLGSDVDSVKKEFLDKKLEYLDHNGERLSKDIFLSGDVKTRLESFHDEYGLPKFSDDETIAHYQKIAYEDLKNVIPDDIEVPHIEIPLGANWLDKNITDSFLSEIVGLDYLNTNYIHGVGWKVNFDGLKDRDFMIATGKDFKANTGVEYINGIDYIEDMLNNKTLVVQKTIKGDKDKTIIYRDPIATQSLESLKKQLKREFKQYILDNDSFSEIAQKQYNDTFNREVARKYDGSHLKLHGANSDIELRKHQKNAVFRFFQELSSLLAHDVGTGKSYTMIASAIEGKRLKVHNKPMIVLPNHVAPQIAAEARRLYPNANIKLIQAVSRKDKNRALASLKNNSHDIIITTYTAFTNMNVAPSAFQDYVEKEIKFLRQIQKKLKEDGNASKRELNSIESRIEKAEERATNYAKSVANDKQNVFFEDLGIDTLMFDEAHYLKNLPIFTAQRNVRGIGSADSQRAIDAFMKISQMRDLPNNRVLFATGTPITNFISDIFTMQRFLGSKDLEAKGIDVFDEWCKMFAGASSEFEMKATGEYKLTSRLRDFSNLPELKAMYYKFADLVTKEDMQKAILEEGGKIIEPKVRRIPVVLKRNQAQIDFMESVKKRAKVLQENPQAAMEKGGDNMLKIISDSNKASIDMRLIDSSYKRDENGKISAAANNILEVYNDFNEHKGTQLVFLDTSVPKKPIKPETLEKWQKELERIDSVIQNQSHNLSDNQLEKLRDKASDLESKIARGSDGFSAYNDLKDLLIEKGIKENEVAFVHDFEGIKKETLSQKINSGEIRVLIGSTSKMGAGSNFQERLAAIHHLDLDWTPANMEQREGRIIRQGNRLMDLVPDFEARIYTYVTEQMSDSLMLQTLEQKTKIIKQIQDPNLKTRVIEDISEDNLHGRLKAMTSPNAEQELEAMNIVKSIDEVENAISTHDLILKNNHNKIENANKLESSMQKDINTLEAFKKQTQDNTTISFGKEKINFAKDNKAKTSKDNKTDTPKATKDKDKKKEKSPESLANEKLNAIIQDFAKSSDNIKVICEYRGLNILAKKGYSGMIDFYLGKDLNEALSISIRLDVRDAAYTDKNYMQRFHNGYNKLISDEYIKELQGQIQKAKDTREKAKKAYEKEIANKESVAELRNSLNEMLVRQAELHSFLGRASDSEIERLKAIYGDGFEDIVKGKFSKESENKALDNNTANNIAENDLEQTLEPTMQKFNYDERKAKDLLEWHKDSSPLTKDENGVPKVFYHGSGAEFEVFEKEKDRSGLGFWFALDKDYAKEKARFRGINGGILYGVFLHVKKPLDLRRANKDYPADIKNELTEKGLNLNSYDTQSREVQDFLRSKGYDGIILDVDSSDFFVVFDSNQIKHIDNKGSYTDTKGNITKTKPKNKESTHTYFNDKSPNIMYANPKHLGIGFLSGTAAGIETDENGNIVGFNPQNFVLGLIGGSVASKAISKLYNNESTQRYATLAIKSIQQDYKSLSENNPAMFAKIMQKFNPRDFLKGKKEINSLSNEIFNKELAKAIESALQNGKVETMPQAEFRNKEEFAKMFDSISGKYGIIETPYKEVKADIKSAWRHFKHNTNGADRENIKGGFFKTFKDPLFIVEQAREGQSSPSVYFYKPFYDNDKKLMNLFGIGIDSVGNIDFKTYYFDEKETRLNAILKSEKIKIVYMQE
>NZ_CP019645.1|WP_155761474.1|1523438_1523597_+|hypothetical-protein
MACGLRKGRTGLNTDFKLKNAESSTQKHIKQDSTTQTNTQTLAKKHLTHQNL
>NZ_CP019645.1|WP_077388826.1|1521750_1522233_+|hypothetical-protein
MRKKLSVMAANTLLTIGLGNTALAEENNGLFIGVHGSVSFFGLEMYNYTSKAYADGGYKDIDMNKFDAPFNVGLFHVGLKAGYQHFFMSMVGARGYLGYDFNGSRVFVKGSKFVAGMKDINMSFQNITLIAYKTLSYYNEWLKYTFLNIISTLQILGREL
>NZ_CP019645.1|WP_077388835.1|1541935_1542208_+|hypothetical-protein
MRIAILSSLFMFSVLYAKCDCLCVNGNVEAICSNAYEVRPVCNPRVCPIVPPSIEPLQTPKLLPLGTTSCHQAQVYNEYTRQYEWQRVCE
>NZ_CP019645.1|WP_077388836.1|1542274_1543768_-|hypothetical-protein
MFRDGNNQAMQLVMQGYSDSIRAKTSNQGLAMANAFNQGLSNAVQTHDNHEQAMRNRALTDEQIQTAKHNNAYLADTHDTRVAQTHQQEMMNDLDIKFKSDTHDYRVGQEQQAERQMKLNNNYQAKLNEEQKLTSASRVNATNNQNYATSSQAKTSKKYSDMERANYEIENVYTDGKGNYYYNSKRTQAMDSATAEARMKRNAEKEQNRREYQNRFTSDNRQVVAGNQAQEAQNTFNMKMGDQQNKMYDEAKTSIQASGDTYDDIVYKLGEAARNNESQITLRNGTKMSVEMASMLGNGMLRGNSGGIGGGININHADKSTIRERDIDAAYNLYDDKDDPQARDRIAMQQKYKKEYGEISKSLESIGHFSQIMQDLDDKNRASLAIGSLTRFIGSGEDYVKFKAQNSITLASMAKQTFGGQISDRDMQIMREQTAKMWESTPATMARLEQTLANQISTLKGKIKGTPIGINIMTPEQQQQYIGLTQLYQAIMQGKKN
>NZ_CP019645.1|WP_077388837.1|1544341_1544932_-|ribonuclease-HII
MLICGIDEAGRGCVAGSLFIASVMLDECYFESFKKLDIRDSKQLTQTQRQERANSIQEFLREHGGRVKIVSFDSINIDSKGLGQCMQMGLKELLLHAKKHQCKSIIFDGNTNFGVQEIDTLIKGDSKHVLISAASILAKTNKDSEMLTLHDLYPQYNLKSNKGYLTKAHIESIAKHGYSPIHRKSYHIKALESRLF
>NZ_CP019645.1|WP_077388838.1|1544933_1546916_-|ferrous-iron-transport-protein-B
MKTLKVVLVGQPNVGKSSLINALSNAKMRVGNFSGVTLEKAEATLNYKDYMITMIDLPGTYSLNGYTTEERVCKDFLDNESYDIILNVLDSTNLEHNLILTLQLQQLDKAKLIALNMIDEAKIDGIMIDTKQLSEMLHTNVCEVSSTKKQNLNILLDTLIATHESYMKTRDTESIQKDSNNIKWHNTQEEIQEHKHNNIGITSTLAQNAQVIVNHIQKVTKPRAAGSAKLDSILLHRIWSIPIFLLAMFLVFQLSFVLGDFFKEMIESGIDTLATFTKDSIRNDLLASLLGDGIIKGVGAVLSFLPLIATLFLGLSLLESSGYMARVAFMLDGLFFKFGLHGKSFIPLVMGFGCSVPAYMATRTLQNKRDKLLTLFIIGFMSCSARLPIYLLFVGAFFSAEYAGFILFGIYLCGFIIALILAKILRIFVFRGESEPFVMEMPRYRIPTLRVIWFSVWGKSYLFLKKAGSVILIGAILVWILANFPKSTLLQEEFNSDIQALATQNLSEREFEEKQKIYENNLLESQLEYSFAGRLGHALEPIFAPLGFDWRLSVALITGFSAKEMVVTTLGVLYALGEEAVDDDLKNQSLQEELRASIDTKAAVAFIFFIMLYIPCFAATIAFINESGKKIYGIYLFIFTTLAAYTFAFIGHEVMGLLGY
>NZ_CP019645.1|WP_077388839.1|1547226_1548405_-|cation:proton-antiporter
MHGQELSTFAVIALLIVAAPYVSRFTRIPVAVVEILLGAFACYFGIFKGSETLNVVAHVSFLYLMLLAGMEVDLRGFSRLGKEFYKKACLYFIILYAAAGSIVLIFNLEWIYIAIFPVMSLGMLVTLIRDYGKNREWLNVALKIGIVGELVSITALVVVQNGYAQNVGTITSWTFYKAFAFLALFVIAFLIIFRIGKIVFWWKPAIKLWFMPTNDSNNQDIRFSFMLFFILIGITTFMDIEDVLGAFLAGMVIATFFAYKHDMVHKLNDIGFGFFVPLFFVYVGSTLNLKEILSNYNVMLQGIYIAFGMLAVRLLAANIAFGSYFKSIKNTTLFALSDCMPLTFLVAIAKLGLDLHAITQEQYYSLIIAATFEGIFFTIFIKVIFYSVRGGR
>NZ_CP019645.1|WP_077388840.1|1548425_1549166_-|hypothetical-protein
MGQTINVVILASGNGTNMENLVLSLHNKTITQAMRQNGVNLTKNSTTKDKAPLQTSPNAFIINSETIQDSMLAKDPLINVLSIVSDNKDAHALHRAKRLGLPTQIIDSTDKSRQEFDKALLLYLTSLQREYGLNCILLAGFMRILGAEFLERLKHIRILNIHPSFLPLHKGLNGIEKSYADSNDFGGVSVHFVTKELDSGMIILQEKIQKIPNESLEDFTQRVHDVEYRLYPQAFLKAFAQGIHNV
>NZ_CP019645.1|WP_004089118.1|1549182_1549470_-|hypothetical-protein
MQQHDKKHKKSHNTQALQNKIRDEEIQELESQILDMFEVAFHFAGLKPSNLDDALNYYMEVMESQDDDLPYNAQTIIANILLIRQDKPEWFDTLN
>NZ_CP019645.1|WP_077388841.1|1549588_1552204_-|heavy-metal-translocating-P-type-ATPase
MQKFILENLDCNSCANKLEKSLQSMPCVESANINFSTNTLYIKTSDIEAIKAQIAKIEPDIIVRSTHENTHNVSYKKELSLLLALLFGFAVCMLCLHYTPLESSSFIKSFNMILGVSYAVLLHYMESLSFLHSIFSAVTPFQILIYIILLLLYIIAGLPIFRAVWRNMKNKVFFDENTLMFIATIAAFCIGEISESVAVMLFFRIGEFLESLALKRSKKSLYDLLDITPEIAHLQIKQADSNSMDSSETIWQDTHPELLKVDDIILVKVGEKIPVDGIIMQGESSLNMQAISGESKPIDVASGDEVLAGAINMQSVLTIKVSKPFSHSQVAKIKAMIEDSSNTKAKSEQIITQFAKIYTPIVFFIALGIAFIPPLFDGEWHEWIYRSLVVLMVSCPCALVLSVPLGYFGALGIASRKGILIKGSTHFSNLAKLQQVVFDKTGTLTQGVFQIESINPLTDISKESLLEIAQRAQRFSNHPIAKAIMQDSKNMKDSKNTHICEIESFEEIGGKGVYAKCCGDRILVGNESLMKDKGIDISPFYTHKDTQDSGFSIIHIAKNGIYQGYIMLGDILKEESKECVQILRNLGVNPLAILSGDNEKSVAHIARMLNIQSYYAGLLPTQKAEKLQELMGLDSISYKCEVGVSMKNKEKLESSACHAKVLAEISSMESQQDKILDSNNKDFSLTAQNDTKMESTTCHVERSETSKRLESNLESKQDISLNAQYDKILDSIKMHPKPCTHPDSAEILDSRKNTTKHKITAFIGDGINDSIVLKQADIGISVGTKDSHSDISKESADIILTNPSPMGIVHAIKIARKIQALTWQNIAFALGTKLILVLLGIAGIANMWLAVFGDVGVALLALLNALRVVRV
>NZ_CP019645.1|WP_077388842.1|1552556_1553801_-|alpha-1,3-fucosyltransferase
MNKRVLNMRILDWWNEDNEVNFYSNALIQLLQQKYDVAYSNTPDFILCGPFGYKHLEYDCVRIFYTGENVRPDFNLVDYAISFDYAVFEDRHLHAPLIFFNTYRSKELQNTLKSRIHLSKYKTKFCGFVASNGYMTEMRDNFFEALCAYKNVDSGGKWKNNIGTSVDDKIEWLKSYKFNICFENGSYPGYLTEKLFDAFMSGCVPIYWGDTSLRCGIDKECNETSNKDSKKDISPEVCTSNFFTRNYKYDENLDSNAMGGGGEYGIFDTRIPNIPPYLFDYKINPKAFINAHEFPTFKDLIDEIKRIDDNDKAFRDMLNEPIFLDDFDPQEFYSQRVFHFLDYIVSQGPTCAKRIGRGSYLQRKENVMKTCPYNIDSSITPKFMHYCMKHRNFIENIRKISEFPRDIIRIMRGK
>NZ_CP019645.1|WP_077388843.1|1554517_1555033_-|hypothetical-protein
MKNKQHTIPTKSKVEKDLSTDEIKQIINTWDLNNPKKSDKLIISKVDESELELLAKDFDFKGNYAVAREIDSEHLAHALNRHGDDSNTANIAISKDEIFEFYPNITKQYDSRVVTENNTIIYSKQINGHFIVIEEVLTGRNKLRFDTAWKQKGKLNEKVLFKNAKVFPNAK

Crispr_ID: NZ_CP019645_3

• CRISPR_ID: NZ_CP019645_3
• CRISPR_location: 2188940-2189024
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP019645_3

Consensus_repeat	Method
AAGAGATAATCACATATATAAGATTCCA	CRISPRCasFinder

spacers of NZ_CP019645_3

>3.1|2188968|29|NZ_CP019645|CRISPRCasFinder
TTTAGCAAGTGTGCAAATGCAGCGGAGAC

CRISPR arrays and Neighbor proteins around NZ_CP019645_3

CRISPR arrays

The CRISPR arrays of NZ_CP019645_3

>merge|NZ_CP019645|3|2188940-2189024|CRISPRCasFinder
AAGAGATAATCACATATATAAGATTCCATTTAGCAAGTGTGCAAATGCAGCGGAGACAAGAGATAATCACATATATAAGATTCCA

>NZ_CP019645|3|3|2188940-2189024|CRISPRCasFinder
AAGAGATAATCACATATATAAGATTCCA	TTTAGCAAGTGTGCAAATGCAGCGGAGAC
AAGAGATAATCACATATATAAGATTCCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019645.1|WP_077389435.1|2193378_2193741_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077389429.1|2190044_2192036_+|hypothetical-protein	unknown	unknown	gnl|CDD|224117
NZ_CP019645.1|WP_077389443.1|2197138_2198809_+|hypothetical-protein	unknown	unknown	gnl|CDD|274009
NZ_CP019645.1|WP_077389439.1|2194631_2195528_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077389441.1|2196207_2196930_+|carbonic-anhydrase-family-protein	unknown	unknown	gnl|CDD|239398
NZ_CP019645.1|WP_077389423.1|2183050_2184616_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|177094
NZ_CP019645.1|WP_077390328.1|2180261_2181650_+|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|379052
NZ_CP019645.1|WP_005217976.1|2192745_2192949_+|DUF2997-domain-containing-protein	unknown	unknown	gnl|CDD|314207
NZ_CP019645.1|WP_004086704.1|2179660_2179963_+|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|179646
NZ_CP019645.1|WP_077389425.1|2184640_2188477_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|372468
NZ_CP019645.1|WP_077389437.1|2193737_2194391_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP019645.1|WP_077389417.1|2174106_2175264_-|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|274232
NZ_CP019645.1|WP_077389419.1|2175614_2176754_-|rod-shape-determining-protein-RodA	unknown	unknown	gnl|CDD|274033
NZ_CP019645.1|WP_077389431.1|2192038_2192734_+|hypothetical-protein	unknown	unknown	gnl|CDD|237177
NZ_CP019645.1|WP_077390325.1|2179316_2179661_+|aspartate-1-decarboxylase	unknown	unknown	gnl|CDD|376751
NZ_CP019645.1|WP_174566020.1|2176809_2179158_+|type-I-DNA-topoisomerase	unknown	unknown	gnl|CDD|235516
NZ_CP019645.1|WP_005217955.1|2195539_2196121_+|radical-SAM-protein	unknown	unknown	gnl|CDD|379137
NZ_CP019645.1|WP_077389421.1|2181671_2182799_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NZ_CP019645.1|WP_077389433.1|2192945_2193368_+|hypothetical-protein	unknown	unknown	gnl|CDD|368177
NZ_CP019645.1|WP_077389415.1|2172642_2174088_-|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl|CDD|234714

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP019645.1|WP_077389443.1|2197138_2198809_+|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.25489e-08
NZ_CP019645.1|WP_077389429.1|2190044_2192036_+|hypothetical-protein	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	5.17821e-12
NZ_CP019645.1|WP_077389441.1|2196207_2196930_+|carbonic-anhydrase-family-protein	gnl|CDD|239398	cd03124, alpha_CA_prokaryotic_like, Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.	9.06305e-83
NZ_CP019645.1|WP_077389423.1|2183050_2184616_+|AAA-family-ATPase	gnl|CDD|177094	CHL00195, ycf46, Ycf46; Provisional.	2.77383e-132
NZ_CP019645.1|WP_077390328.1|2180261_2181650_+|PDZ-domain-containing-protein	gnl|CDD|379052	pfam13180, PDZ_2, PDZ domain.	2.30978e-08
NZ_CP019645.1|WP_005217976.1|2192745_2192949_+|DUF2997-domain-containing-protein	gnl|CDD|314207	pfam11211, DUF2997, Protein of unknown function (DUF2997). This family of proteins has no known function.	9.26889e-06
NZ_CP019645.1|WP_004086704.1|2179660_2179963_+|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|179646	PRK03762, PRK03762, YbaB/EbfC family nucleoid-associated protein.	9.84409e-31
NZ_CP019645.1|WP_077389425.1|2184640_2188477_+|AAA-family-ATPase	gnl|CDD|372468	pfam13087, AAA_12, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	5.65507e-38
NZ_CP019645.1|WP_077389417.1|2174106_2175264_-|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|274232	TIGR02614, Putative_lipid_II_flippase_FtsW, cell division protein FtsW. This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	6.88981e-79
NZ_CP019645.1|WP_077389419.1|2175614_2176754_-|rod-shape-determining-protein-RodA	gnl|CDD|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	6.09243e-106
NZ_CP019645.1|WP_077389431.1|2192038_2192734_+|hypothetical-protein	gnl|CDD|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	7.32234e-05
NZ_CP019645.1|WP_077390325.1|2179316_2179661_+|aspartate-1-decarboxylase	gnl|CDD|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	5.55117e-67
NZ_CP019645.1|WP_174566020.1|2176809_2179158_+|type-I-DNA-topoisomerase	gnl|CDD|235516	PRK05582, PRK05582, type I DNA topoisomerase.	0
NZ_CP019645.1|WP_005217955.1|2195539_2196121_+|radical-SAM-protein	gnl|CDD|379137	pfam13353, Fer4_12, 4Fe-4S single cluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2.98978e-36
NZ_CP019645.1|WP_077389421.1|2181671_2182799_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	7.762e-31
NZ_CP019645.1|WP_077389433.1|2192945_2193368_+|hypothetical-protein	gnl|CDD|368177	pfam04889, Cwf_Cwc_15, Cwf15/Cwc15 cell cycle control protein. This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologs. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing.	0.0081011
NZ_CP019645.1|WP_077389415.1|2172642_2174088_-|exodeoxyribonuclease-VII-large-subunit	gnl|CDD|234714	PRK00286, xseA, exodeoxyribonuclease VII large subunit; Reviewed.	3.54048e-157

Protein sequences

>NZ_CP019645.1|WP_077389425.1|2184640_2188477_+|AAA-family-ATPase
MQHYYHAFSQNADEANRKRECIEKEILPFKQYIDTAIKSLEKKKVRAKWERVETEFNATLEINGYFYKYKPLGQISLKDEFYKQLDSILFVGNLPQTRDYDEKLFITLENGKKIKISLKDGDIAQDYEILCRFCEIADEVSKDFVSQSPQLTKTEELLDSKNCHVERSEISSIESSKDFSPFSKAQNDKNLETTPTSHANKTTNSSGCSMALDGLWLNCDGRSYLSDNDYPSNNRSNCIDKGEFLQNLDTGFIHLDSLSLDNDTKQKLKDFSIKKVSWSGDDLEIKTLKQWLNNGKLDLDSKQVEIKSLQDNVILLKSDINKANIIQKDGYLLPATLEINYIQDNHKVLQDNKTHKIIYCKNEIKSQLCNPIEKHLAKSYCDFQSLCDKSGNKIDIEKQDSKQVFIKDIKKLDDKTILYDKFGISYTLKKVKNEGFNIRLLRNDDEREDEDEIESPLRFFLDSDIQVMACLDGHKEPQECRVKIINRDEFIIELLYKNRAILPRQYSILETKPNPYRLKCQRNAIQNLIKMPLAQSHTLLKLFASRTKDKISWLTKDSKIIDITEWEVLTDENREGANIQRNFIQQALNTKDFALLEGPPGSGKTTTILELIAQIIKQNKRVLLCGSTHVAIDNVLERLKERELIEKLNIFPIRVGSEGALSEEVKEFRLGDFARNYEDSLLEKYSVYNDLEKDSNDENKQGKIGLKFFMQCANLVCGTTIGILQYPAFKIQDEEEDSKKRNKKTIKPIMPDFDYLIIDESSKTTFQEFLVPAMYAKKWIIVGDTRQLSPFVDRDELEDNISNLALRYNKINKGFDFLESSYQQACFLLYLLSKIYKENGFNIKIAMGVSSEILWILEQEIEIRTDEKRDNFGVLNNRLKVGYIKDLQATSYFDNLNKHWIFYDEDLVKKDSLHNPLKHLIPSDFIDFDNLALLYQYKAKHKNTTLMFDNNAKNTESFLKAIKDYRQERSFASEIAWRLSREFELRTFSDSNKAKNKNQSYTKTIDELLPKSHKDRNLIRNKISSIANISLPSILESLIKGVSDRRSEREDSAIRSGFTQDELKQRHSILSTQGRMHEDISRFPREQFYKEANALKDLSNLNREWSYTRYKKRSVWINVDSKSYRGRNEKEAEFLIKELRAFIDFATNNPHPLNETWSVAVLSFYKGQTRILESKLQEYTGLKHKSTDFTREWNGTEIQMRLCTVDKFQGQEADIVFLSMVNTDKIGFLDNPNRLNVGITRAKFQLVILGKYDYFSQCKDNMLKQFALHHKALHKGNK
>NZ_CP019645.1|WP_077389423.1|2183050_2184616_+|AAA-family-ATPase
MQHEDEVFEILDSVNIIQIVSFEWERIDAISAKVAHKAGKTLYKWNIAQGLSRFDNENKIFGSFDEKEASEVLEWFQSNEASNSIVILEDFYPLLDENPQNIRIFRNIARGPKDRTIILSQPFQKIPQELDKDVHIITLDLSNKADLEVIFRQCIEDAKYGSQELDENLKDRLIESALGLTIMEARKVFMRAIKRTKGKLGEDEIKLIVSEKEHIIKNSGFLEYYHHKEGLSDVGGLDELKNWLTKRGRAFHKEAKEYGLEIPKGVLLLGIPGTGKSLSAKAIGSEWKFPIIKLDMGRIFGGIVGESESNIRKALQITEAIAPSILWIDEIEKGFSGLSSSGSTDGGTTSRVLGTFLSWMQDKSKPVFVVATANDISKLPPELLRKGRIDEIFFVDLPSFNARKAIISIHLKRLKRNPSDFDLDALSKACMGFSGAEIEECIKDALFAAFNDAKEVDDSYIIDSAEKTYPLSKTMSESITSMRKWAKARAVYASSEEFDGELKNDKDVPQLRQEITANPFM
>NZ_CP019645.1|WP_077389421.1|2181671_2182799_+|HAMP-domain-containing-histidine-kinase
MKKVHKKNKHNAKKKEAYKQEHLTKNSIMLEDVAYDNAALQSTLGLGDTQSLLNLLHELILQSYKIEKEFKDFKVLIESVLEMIPQAVIVFNENGSLFYQNKKASNLKGLLDIDLNFSSEFEVKIDNNVYLMQSSKISHKQIITATNITEQKRQERLASMGQVSAHLAHEIRNPIGSLSLLAGVLSKRVDEKSMEIVDEMKKSIWRVERIIKSTLLFSKGVQANKQQHFFADFKQSLEQVISEYGYTKEIEVAFEIDYNDAFYVDFSLYEIALHNMLCNAIDAIEEGECESGKIRICFFRDCDMILCRIYDNGKEIEDITSLFEAFKTTKLKGHGLGLALSRQIALAHDGELCANNTEGKFFEIRVPLTPLCSGE
>NZ_CP019645.1|WP_077390328.1|2180261_2181650_+|PDZ-domain-containing-protein
MYGKSKTEEKIDYAHCAAYYKQASLNLGKGLYAIKLKSGEIIGYNPTRPQLKNLVKYDPFTGLFQVSGRVDSKYAYELSAIDDYALSRELASAGINGAKPGRFQTHQAGFLKYAEFSAPTQKNGVISNICYKIYGLSVGGNGFIEKSYIDRFLNQQQPYHGDIGVRFDVASAENATFVVQFSDPFFPSNPFKRGDILISINDIAPKDWGELELIISNLMPDEVAQIKIKRGENVKNIKVKAKKRYGGMLLADSFLERFNLVISNDLIVQKVPNKGPFSKLKKGDRILFINDIDMRHFKPRNTTERNHLLRELFTRIQDNQVDFLEQKIAYDAEKEATKRRNADILEQFQSKEVKKERHNDFYYKMADNIRNFASSDIAIGTNITGERTSKKGDLHSFSGDGILRDSDTQSMRTIYDMYNSGGKSTNKPKKERIKEYEALVEYGGQMNFLVDRQGFQFRVPLE
>NZ_CP019645.1|WP_004086704.1|2179660_2179963_+|YbaB/EbfC-family-nucleoid-associated-protein
MFDPKDLQNMLGSVQEQLKEMDAKAKEKIIESKSGGGLINVQFNGAGELIDIEIDDELLQDKQSLQILLISAINEGYKQMQESRQDDVFEQIKNMNPFKF
>NZ_CP019645.1|WP_077390325.1|2179316_2179661_+|aspartate-1-decarboxylase
MMYAKIHRAVVTDANLNYVGSISIDESIMESSGIIEGMKVDIVNVNNGERFSTYAIRAKAKSGTICLNGAAARKVQKGDIVIIIAYASMKMKYAKDFKPQVVLVDSKNRIVEEH
>NZ_CP019645.1|WP_174566020.1|2176809_2179158_+|type-I-DNA-topoisomerase
MLELQVIFTTKIKASVFMATAKAKKTTTKENTKTSNKKATSKTATSKKSSGSKNLIIVESPAKARTIKTFLGKDYEVIASKGHIRDLPQHRFGITIKDKHFIPTYDISKDHALLVKEMQDLHKSAEVTYIATDEDREGEAIGYHIVEALNGDISQFPRIVFHEITKSAITHSLDNPRLIDMDRVNAQQARRLLDRIVGFKLSGLLSQKIGRGLSAGRVQSSALKILVDREKEIRAFNPQDYFLIEAYFVADSKAKEEERLVFDLARFKDKKIEKLVLQDKKEVEEILAILQKEKFRVETIQQKERVTKSPPPFMTSTLQQTSSNLLGFSPTKTMSIAQKLYEGVKTKDGLAGVITYMRTDSLNIAKEALDNAREFINTNMGKDYLPSKAKIYTATQKGAQEAHEAIRPTNLSFTPQIAAGYLSNDELKLYTLIFNRFIASQMKDAIFESLSVSVIGELSEFKITGRRLVFDGFYKILGNADKDKLLPQFKEGQAIDFKDIQSIQKTTEPPPHYSEAGLIKTLESLGIGRPSTYAPTIRILIDRKYVELEKKQLIVQDIAFNVIAMLEANFEEIVDSGFSAALESKLDDIAENKLEWEEVLWEFYEPFIEKITKGKTDIESQKMMKPTGELCPECGNELVIRNGRYGEFVSCSNYPQCKFIKKEKQEVETSDEICEKCGRPMVVKMSKRGKFLACSGYPECKNAQPLEKPKELSVACPKCGGKLLERKSKRGIFYGCGNYPKCKFITNAEPTNEKCDKCGGMLCWHKTKENTKVCVECKNVVT
>NZ_CP019645.1|WP_077389419.1|2175614_2176754_-|rod-shape-determining-protein-RodA
MLFGSRITTHFDYVLILLILPLVFTSLYLLSETSQTLLIRQSSYAFLGIFIFLFIFFIPFRYLYKGVVVFYIICILLLLAVEVIGTTKLGAQRWINIGGFSLQPSEPVKIAVVLFLAHYVQKNPPPQEGYGWIEFLKISVFILIPFFLILIEPDLGSAIIVLVMGYGMLFIIGVHKKVWLTCIIAGLLFSPIAFKFVLKPYQVDRIMKLVSGNTSSQVQQSLIAVGSGGLTGRNYEDATQANLKFLPVATSDFIFAHFAERFGFLGSCALIALYLFIVLHLLSFCFLDSQDYFLKVIASCLAMLFFVYTSVNIAMTIELAPVVGIPLPLFSYGGSSFITFVILIAMFENATTFRFSFSNFKETTPFGNFMRIPKRRARL
>NZ_CP019645.1|WP_077389417.1|2174106_2175264_-|FtsW/RodA/SpoVE-family-cell-cycle-protein
MADTRLFFLVTALLGIAICMSYSLSSYAVLYYGYGQFHFLYRELFASCLGVMLMWGLSYFNVEKHLLGFGLVLLISSFIVIIVLPFLPDSYATSAGGAKRWLRLPNISLAPLEFFKIGYIIFVAWSFSRKFNNPRSLPFLEQLGILIPHLFLFMCVAALISTLQNDLGQIILLSLVFIVMLICAGGRFSLFTLALGVVSVMGTILIVTSPHRIKRVREWWINIETLIRSYAPNFSLLSDGVDAGGQVQNATYAFYNGGHFGVGIGESIVKLGFLGEVHTDMILAGISEELGLFGLLVCVLLVFMIVFRIFKIAFRLQKSFYSLFCVGIAALIGISFLINAFGETGIIPIKGMAVPFLSYGGSSLLALCIGIGLVLALSTKVDLGK
>NZ_CP019645.1|WP_077389415.1|2172642_2174088_-|exodeoxyribonuclease-VII-large-subunit
MQAQPHIPLVLQVSQLTMQIKSLLESDFSYVEVEGEVSGFTHHNSGHIYFNLKDENATIACTFFRHNARNNPIKLQNGDKIIAKGNISVFPPRGTYNLNIVKCVHSGIGDLKAQYEALKKRLEERNYFCKNKPLPRFPKRIILLTSQTSAALQDMIKVASKRYCLCEFILIDTLTQGREAKHSIAKNLAYADRLGADILVLARGGGSIEDLWSFNEMEVLEAIFACKTPVVSAIGHEIDYLLSDYVADVRAPTPSAAMEMILCDKDNLITQLCDMESMLTHTMQTHITQKKSILNHLAQSLEILNPLQKIAQYKLLLQTLTQNLQDSIKWFYTQKKHALLQQQERLDLAKPTQKLLIMKTEIQSLSKKLHGEFSYIIEQKINQTKQIELELKNTMLQMMTRKRAMLNFNLHDSMQNALRQKRLMLNNLIDMLHALDPSKKAQYGFAQILKDNKLIQVSELQENDVIEIIDSSGIRNARILG
>NZ_CP019645.1|WP_077389429.1|2190044_2192036_+|hypothetical-protein
MISIAHKEITKDYGDSVIENVWVDSNSCHVERSETSQSLESTQSTKETTQILGTMQAIKNSMLETLQTAQDSIICLYTSFLDPEIIKLIPEIAKNNRIYIYTKDQNTLQELSHHSLVRLGDNLAGSFVLIQKDKNIQGFFSTKDFDIESNQLFLELDSNQCNDFWHYFITCFWKDAKKEFIAGKEEEIKEMNQKDFIPPFQNGFDTEFIRDSISQRKSVALIQLQTNSPLIDLLQDFEECKFFLQDFHTLSDEMLLQDKETNFIECPVGFDSINNDIFLSNNNTLLYSIRVTGKQTQIFKAMLQNLIKNKTKSFKHEVALKELIDKTIHYLDGKTAKIEAHTTHKDSIQCTSFLDKDEFETQELDYKQIWQDKYPHTCKITYSFDTIPFYTPAHFKQAHLYNEWENTHKALHDTISKALNNIESIYKKQDELNAFQALLSEAKNFFKRFFLGKNTNLKDLTAKLNEIKEKATLETLNIDSTQSYIQELEKHIKTINENSGEIDLKLDEAKEHNEWQTRKNKLENEIEELQQHCRTKQQDLNTKEKECKDKKEKLDSMQKEIQNLENEKDKAKAHLDTLKQEQQKLSKNNQEKEEYCRKKQKEKADKENKSNNNEKTINATKDRLKELQQKANELQQKILEAKNKELENLKQNQHEKEKSSDKE
>NZ_CP019645.1|WP_077389431.1|2192038_2192734_+|hypothetical-protein
MAKKKNNQQKNAIQNKQQIDASSTSLEQQLKDILESRAKLEKQQQDLESENKIIKDEIHEIDRILIDNKQQMESIKGQMQIKQQSVKAAQDNLDETTQTLDSKKSNYNKEKKDKEALDKYIDTEKQNLQKDENKLKNLKDELKTKYEKFSYNKKDSKESKSSLAFMDKTQSRTQQEIHMVIPKENRPTTGVLKEDKHERLLEISQWDEVESATEEAQRLKASLSVKHDKSQ
>NZ_CP019645.1|WP_005217976.1|2192745_2192949_+|DUF2997-domain-containing-protein
MKEEKIIVTINEDGSLDLKSEGIKGEACMGEIEALLSEDMDIESDKKTDEYYQKVSQTQSATLRSKK
>NZ_CP019645.1|WP_077389433.1|2192945_2193368_+|hypothetical-protein
MSRRVITRTPIIDKECLIEALKASNCQYQDQGNRISVQIGCGITYIQKDTHFSVDYYSDHIDERNFVESVNKAYLRIYKAKLECLERERLEEEARKERERLEAFKEAQKAQIIEKAKKQGYKVKEVKKGDKIQLVCVRYG
>NZ_CP019645.1|WP_077389435.1|2193378_2193741_+|hypothetical-protein
MAFFEIQNQEIKVFLTENLSGSETMQRRYDLLNKFATKQNIPHFKAAELLANAEGVVWTKRMLDIANFVTDETAESLPSSVQQPIMSIRPDKRRFKPLPNIYKNITQNIKQNLTIERNSK
>NZ_CP019645.1|WP_077389437.1|2193737_2194391_+|hypothetical-protein
MNSTEKQNALVVYNPDNSLPHIATNSATNTNTTFRIFGNSDNNAMFPKTLTETIQEIISMLKEINQTAKTSDLQPLIDLAIGLDSETTKDISSDIQTLFKQFSNLETYLNKKLDKLDRILSKSIDFDTYSQTDKALINKIKSIQEILHNIFISINIDEGETTRVKKRAYMRSITTAKNAIKQIEELLDGTDLREPIPETIKQDDGKRYADNPFLGRV
>NZ_CP019645.1|WP_077389439.1|2194631_2195528_+|hypothetical-protein
MAMTTSFNLISNENAIIPNIILRTMQDIEHMLKELKIAVKNPIIYSSDDIKNFANLNPWLDLAYNIADTIDPSLLGNTTKTLDDATQCSVFDPEIVVDKQFMQSVSDSFSQCSAMNARINQKLDELDEIMSKSIDISRYTKDEKAVLTQVQTIYETLHSTLQSIIDNVNGSTDTNSVIGRGITSLIDRIDKYANDYGLDNDDNDSNKQDNTMKIDSSKYGDNIRTRKRVYMRWINSLKDCMDSIQNTIGSNTLRANHAKPTTPQPNQTQSNTQAQNTDEKLSKESNKDIQPHQRNPFL
>NZ_CP019645.1|WP_005217955.1|2195539_2196121_+|radical-SAM-protein
MQLSSIKEYSQIYGFEPSFVIWTQGCPIHCKGCWNTHTWDSKGGFTMDIESIFNNIKEQKDSKTLPIQAVTILGGEPFYQYDELYKLVSLIKSLDLGIIVYSGYEKDELIQMKKNSIFSLIDVLIYGRYIESLRDLNLHLRGSSNQVIDFLSNRYNESLIKDGNYIEIDIDNFGGLDIVGYIEPTDSIITQNL
>NZ_CP019645.1|WP_077389441.1|2196207_2196930_+|carbonic-anhydrase-family-protein
MKKICLSLVFSIGSVYAAHWGYDKHNGPDMWAKLDPKFKLCSSGLKQSSVNIESKKTTESKNELHLLYGTNSKDIINNGHTIALHFNEAGGLVYQNRKYNLVQLHFHTPSETQIEGKSYPMEMHMVHKDEKNNYLVLAVLFRKGQNNIMLNNVLSYAPIDIDKAHQMDMIYISQLLPKNHGYYAFSGSLTTPPCNEGVQWIVLKESVEASQAQIDAMHAILKDNARNVQPLHDRVILSAP
>NZ_CP019645.1|WP_077389443.1|2197138_2198809_+|hypothetical-protein
MKDVIEKLEIILNQGLYGRDEEVRLALLCTLSNKPLLLYGHDDAKDIQMRFEALFGETPIKAKITAGSNLSKNKDKLSKYTAYCCLGNHNNTEHLYDYLFAPKNTNVIEKLKQLAPEANKLKKFFQDYNFTQFWDEENRAKAINFIESLASHANPTGELAGDIAMLDDAEQNLVKQLSNISDKRFKDFLHLLAVNLIINNRKEITPIDFGMFYYCLRDWSDGVRYLETTICASLSNDELPTFVFHDEEYEKTCKETFFKSYEQYAFLIPNLEYMVYVPYSSSPSIPANEIFVRLDSFYTQFQNLVCEETSDDIAKDMQEVATKENILKDAQLKEMELKETQLAQVQLKRSAFKSVKDALDERLKIANAKESEFREQREILESKYKDAKTTDRREGLESQIAEVQAKEDQFKEIRLNLEAQLQDAKNTLEDKLKQTKEILEEKLQEVKAKELDLKEAQDKLNQKLTNRKGNMDVRIKEGREYLTQLRTLPVNLNKAVDACRKQIDAVSKPNPIWANPLKIHLAALYKIQKNLPNMIKAFDSQVKKYEEHAKQSTQTR

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019645_1	1.1|448195|29|NZ_CP019645|CRISPRCasFinder	448195-448223	29	MN694165	Marine virus AFVG_250M579, complete genome	16833-16861	3	0.897
NZ_CP019645_1	1.1|448195|29|NZ_CP019645|CRISPRCasFinder	448195-448223	29	MN694486	Marine virus AFVG_250M318, complete genome	19492-19520	6	0.793
NZ_CP019645_1	1.1|448195|29|NZ_CP019645|CRISPRCasFinder	448195-448223	29	AP013967	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5G-MedDCM-OCT-S24-C168, *** SEQUENCING IN PROGRESS ***	5214-5242	7	0.759
NZ_CP019645_1	1.1|448195|29|NZ_CP019645|CRISPRCasFinder	448195-448223	29	AP013969	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5G-MedDCM-OCT-S41-C273, *** SEQUENCING IN PROGRESS ***	1812-1840	7	0.759
NZ_CP019645_1	1.1|448195|29|NZ_CP019645|CRISPRCasFinder	448195-448223	29	AP013968	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5G-MedDCM-OCT-S25-C165, *** SEQUENCING IN PROGRESS ***	5316-5344	7	0.759
NZ_CP019645_1	1.1|448195|29|NZ_CP019645|CRISPRCasFinder	448195-448223	29	MK554696	Fusobacterium phage Fnu1, complete genome	57976-58004	8	0.724

1. spacer 1.1|448195|29|NZ_CP019645|CRISPRCasFinder matches to MN694165 (Marine virus AFVG_250M579, complete genome) position: , mismatch: 3, identity: 0.897

tactgcttttgtatttatgcctatttgct-	CRISPR spacer
taatgcttttgtatttttgccta-ttgctg	Protospacer
** ************* ****** ***** 

2. spacer 1.1|448195|29|NZ_CP019645|CRISPRCasFinder matches to MN694486 (Marine virus AFVG_250M318, complete genome) position: , mismatch: 6, identity: 0.793

tactgcttttgtatttatgcctatttgct	CRISPR spacer
ttttgcttttgtatttattactatttacc	Protospacer
* .***************  ******.*.

3. spacer 1.1|448195|29|NZ_CP019645|CRISPRCasFinder matches to AP013967 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5G-MedDCM-OCT-S24-C168, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

tactgcttttgtatttatgcctatttgct	CRISPR spacer
ctctgcttttgtactcatgcctattacat	Protospacer
. ***********.*.*********   *

4. spacer 1.1|448195|29|NZ_CP019645|CRISPRCasFinder matches to AP013969 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5G-MedDCM-OCT-S41-C273, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

tactgcttttgtatttatgcctatttgct	CRISPR spacer
ctctgcttttgtactcatgcctattacat	Protospacer
. ***********.*.*********   *

5. spacer 1.1|448195|29|NZ_CP019645|CRISPRCasFinder matches to AP013968 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5G-MedDCM-OCT-S25-C165, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

tactgcttttgtatttatgcctatttgct	CRISPR spacer
ctctgcttttgtactcatgcctattacat	Protospacer
. ***********.*.*********   *

6. spacer 1.1|448195|29|NZ_CP019645|CRISPRCasFinder matches to MK554696 (Fusobacterium phage Fnu1, complete genome) position: , mismatch: 8, identity: 0.724

tactgcttttgtatttatgcctatttgct	CRISPR spacer
ctctacttatgtatttatgcctattctaa	Protospacer
. **.*** ****************.