CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018822	Streptococcus gallolyticus subsp. gallolyticus DSM 16831 chromosome, complete genome	2 crisprs	DEDDh,cas3,csa3,csm6,WYL,csn2,cas2,cas1,cas9,DinG	0	6	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018822_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018822_1

1470189-1470260

Orphan

Consensus_repeat	Method
CAGTCCAGTGGACTGTTTTTTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018822_1

>merge|NZ_CP018822|1|1470189-1470260|CRISPRCasFinder
CAGTCCAGTGGACTGTTTTTTAACGAGTCTTGAAATTAATGAACGAGTTCAGTCCAGTGGACTGTTTTTTCA

>NZ_CP018822|1|1|1470189-1470260|CRISPRCasFinder
CAGTCCAGTGGACTGTTTTTTAA	CGAGTCTTGAAATTAATGAACGAGTT
CAGTCCAGTGGACTGTTTTTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018822.1\|WP_003065423.1\|1466267_1466798_-\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NZ_CP018822.1\|WP_077497026.1\|1470306_1470888_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236304
NZ_CP018822.1\|WP_009854474.1\|1485157_1486357_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224057
NZ_CP018822.1\|WP_074581183.1\|1477058_1477985_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NZ_CP018822.1\|WP_012962119.1\|1463061_1465230_+\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|224287
NZ_CP018822.1\|WP_009854460.1\|1467659_1468154_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NZ_CP018822.1\|WP_000124839.1\|1465618_1465978_-\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NZ_CP018822.1\|WP_009854462.1\|1468382_1468874_-\|EbsA-family-protein	unknown	unknown	gnl\|CDD\|375082
NZ_CP018822.1\|WP_077497038.1\|1482057_1483818_-\|alpha-L-Rha-alpha-1,3-L-rhamnosyltransferase	unknown	unknown	gnl\|CDD\|377447
NZ_CP018822.1\|WP_077497024.1\|1468927_1470145_-\|peptidase-T	unknown	unknown	gnl\|CDD\|235484
NZ_CP018822.1\|WP_077497020.1\|1461763_1462927_-\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NZ_CP018822.1\|WP_077497022.1\|1466963_1467644_-\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|234579
NZ_CP018822.1\|WP_077497032.1\|1475411_1477001_-\|beta-carotene-15,15'-monooxygenase	unknown	unknown	gnl\|CDD\|274774
NZ_CP018822.1\|WP_077497040.1\|1483814_1485161_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|132997
NZ_CP018822.1\|WP_009854461.1\|1468198_1468396_+\|ferredoxin	unknown	unknown	gnl\|CDD\|224064
NZ_CP018822.1\|WP_077497030.1\|1473988_1475329_-\|GBS-Bsp-like-repeat-containing-protein	unknown	unknown	gnl\|CDD\|369899
NZ_CP018822.1\|WP_077497034.1\|1478103_1479573_-\|glucosyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372986
NZ_CP018822.1\|WP_077497036.1\|1479592_1482061_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293739
NZ_CP018822.1\|WP_077497028.1\|1470900_1473873_-\|GBS-Bsp-like-repeat-containing-protein	unknown	unknown	gnl\|CDD\|119382
NZ_CP018822.1\|WP_003065422.1\|1466029_1466230_-\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676

Protein	Function_ID	Function_description	E-value
NZ_CP018822.1\|WP_003065423.1\|1466267_1466798_-\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	1.75289e-87
NZ_CP018822.1\|WP_077497026.1\|1470306_1470888_-\|hypothetical-protein	gnl\|CDD\|236304	PRK08581, PRK08581, amidase domain-containing protein.	0.000937303
NZ_CP018822.1\|WP_009854474.1\|1485157_1486357_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224057	COG1134, TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	2.05857e-120
NZ_CP018822.1\|WP_074581183.1\|1477058_1477985_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.43945e-84
NZ_CP018822.1\|WP_012962119.1\|1463061_1465230_+\|LTA-synthase-family-protein	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	7.80516e-164
NZ_CP018822.1\|WP_009854460.1\|1467659_1468154_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.2444e-05
NZ_CP018822.1\|WP_000124839.1\|1465618_1465978_-\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	5.85365e-67
NZ_CP018822.1\|WP_009854462.1\|1468382_1468874_-\|EbsA-family-protein	gnl\|CDD\|375082	pfam17255, DUF5322, Family of unknown function (DUF5322). This is a family of unknown function. The uncharacterized family is mainly found in Bacteria and consists of two putative trans-membrane domains.	3.37892e-59
NZ_CP018822.1\|WP_077497038.1\|1482057_1483818_-\|alpha-L-Rha-alpha-1,3-L-rhamnosyltransferase	gnl\|CDD\|377447	pfam05045, RgpF, Rhamnan synthesis protein F. This family consists of a group of proteins which are related to the Streptococcus rhamnose-glucose polysaccharide assembly protein (RgpF). Rhamnan backbones are found in several O polysaccharides of phytopathogenic bacteria and are regarded as pathogenic factors.	0
NZ_CP018822.1\|WP_077497024.1\|1468927_1470145_-\|peptidase-T	gnl\|CDD\|235484	PRK05469, PRK05469, tripeptide aminopeptidase PepT.	0
NZ_CP018822.1\|WP_077497020.1\|1461763_1462927_-\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	8.98928e-134
NZ_CP018822.1\|WP_077497022.1\|1466963_1467644_-\|(d)CMP-kinase	gnl\|CDD\|234579	PRK00023, cmk, (d)CMP kinase.	6.86595e-124
NZ_CP018822.1\|WP_077497032.1\|1475411_1477001_-\|beta-carotene-15,15'-monooxygenase	gnl\|CDD\|274774	TIGR03766, hypothetical_protein_lp_2141, conserved hypothetical integral membrane protein. Models TIGR03110, TIGR03111, and TIGR03112 describe a three-gene system found in several Gram-positive bacteria, where TIGR03110 (XrtG) is distantly related to a putative transpeptidase, exosortase (TIGR02602). This model describes a small clade that correlates by both gene clustering and phyletic pattern, although imperfectly, to the three gene system. Both this narrow clade, and the larger set of full-length homologous integral membrane proteins, have an especially well-conserved region near the C-terminus with an invariant tyrosine. The function is unknown.	8.57377e-14
NZ_CP018822.1\|WP_077497040.1\|1483814_1485161_-\|glycosyltransferase	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	5.00137e-27
NZ_CP018822.1\|WP_009854461.1\|1468198_1468396_+\|ferredoxin	gnl\|CDD\|224064	COG1141, Fer, Ferredoxin [Energy production and conversion].	2.9513e-15
NZ_CP018822.1\|WP_077497030.1\|1473988_1475329_-\|GBS-Bsp-like-repeat-containing-protein	gnl\|CDD\|369899	pfam08481, GBS_Bsp-like, GBS Bsp-like repeat. This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp. Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology.	3.88263e-24
NZ_CP018822.1\|WP_077497034.1\|1478103_1479573_-\|glucosyltransferase-domain-containing-protein	gnl\|CDD\|372986	pfam14264, Glucos_trans_II, Glucosyl transferase GtrII. This family includes glucosyl transferase II from the Shigella phage SfII, which mediates seroconversion of S. flexneri when the phage is integrated into the host chromosome.	7.96117e-19
NZ_CP018822.1\|WP_077497036.1\|1479592_1482061_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	1.65803e-46
NZ_CP018822.1\|WP_077497028.1\|1470900_1473873_-\|GBS-Bsp-like-repeat-containing-protein	gnl\|CDD\|119382	cd06522, GH25_AtlA-like, AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml autolysins from Streptococcus mutans which have a C-terminal glycosyl hydrolase family 25 (GH25) catalytic domain as well as six tandem N-terminal repeats of the GBS (group B Streptococcus) Bsp-like peptidoglycan-binding domain. Other members of this family have one or more C-terminal peptidoglycan-binding domain(s) (SH3 or LysM) in addition to the GH25 domain.	1.80436e-70
NZ_CP018822.1\|WP_003065422.1\|1466029_1466230_-\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	1.18923e-18

>NZ_CP018822.1|WP_077497024.1|1468927_1470145_-|peptidase-T
MSYENLLNRFLSYVKVNTRSNPDSTTTPSTQTQVDFALNVLKPEMEAVGLQDVHYLTNGYLVGTLPANDSTKTRKIGFIAHMDTADFNAEGIKPQVIENYAGGAIEVGQSGYALNPEEFPNLNNYLGQTLVTTDGTTLLGSDDKSGIAEIMTAVEYLVAHPEIKHGEIRVGFGPDEEIGVGADKFDVDDFNVDFAYTVDGGPLGEIQYETFSAAALEVDFMGRNVHPGTAKNQMINALQLAIDFHNQLPENERPENTEGYEGFFHLHGMEGTVEKAHSSYIIRDFEDDSFENRKKLVQEIADKMNAELGKESVIVNLHDQYYNMKKIIEKDMTPVELAKEVMEDLEIKPVIEPIRGGTDGSKISFMGIPTPNLFAGGENMHGRFEFVSLQTMEKAVDVIIGIVQK
>NZ_CP018822.1|WP_009854462.1|1468382_1468874_-|EbsA-family-protein
MIKIFGKMRYHWQPELSWSIIYWSIAVAPMFIGLSLLFERTKIPSQFFILFAIFIVLVGLGFHRYFVIEENGRLRIVSLNPFKKSSVAIAQIKKIEVNKSGIIIKIKNQPDRIFYMRKWPKKYFLDALAVHPDFLGEVELIDNFIKLDYFEAYKANKKAPTKS
>NZ_CP018822.1|WP_009854461.1|1468198_1468396_+|ferredoxin
MKVSIIPEKCIACGLCQTYSKLFDYHDDGIVKFADSEDLEKVVPNSDQDTLTAIKSCPTKALTIL
>NZ_CP018822.1|WP_009854460.1|1467659_1468154_-|LysM-peptidoglycan-binding-domain-containing-protein
MAKQPWEEKVVDDNEIKISRKTKGSAISTPLLTALLSIFFVIVVAILFVVFYTSNRGSDKASETSNFYGASSSSVVSSSSEASSSETTAETTTDESSTDASSDDTTESSSSTGSGDTITVLSGEGAASIAARAGISVETLYELNPDHMTSGYWYANPGDEVYIN
>NZ_CP018822.1|WP_077497022.1|1466963_1467644_-|(d)CMP-kinase
MKSIRIAIDGPASSGKSTVAKIIAKNLGYTYLDTGAMYRSATYLALQNGLTENNVQEILEALSKHSISFGRAEDGSQTVFVGDKDVTLAIRQNDVTNNVSWVAAIPEVREELVEQQRRIAKNGAIIMDGRDIGTVVLPDAELKIFLIASVEERAERRFKENQEKGIETDFETLKREIAERDYKDSHRKVSPLKAADDAITFDTTGVDIDGVVKFIQEKAEKIIDMD
>NZ_CP018822.1|WP_003065423.1|1466267_1466798_-|translation-initiation-factor-IF-3
MKIIAKKDLFINDEIRVREVRLVGLDGEQLGIKPLSEAQAIADDANVDLVLIQPQATPPVAKIMDYGKFKFEYQKKRKEQRKKQSVVTVKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFRGRMITHKEIGAKVLAEFAERTQDIAIIEQRAKMDGRQMFMQLAPIPDKK
>NZ_CP018822.1|WP_003065422.1|1466029_1466230_-|50S-ribosomal-protein-L35
MPKQKTHRASAKRFKRTGSGGLKRFRAFTSHRFHGKTKKQRRHLRKAAMVHSGDFKRIKAMLSGLK
>NZ_CP018822.1|WP_000124839.1|1465618_1465978_-|50S-ribosomal-protein-L20
MARVKGGVVSRKRRKRVLKLAKGYYGAKHILFRTAKEQVMNSYYYAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVNDAAAFTALADAAKAKLGK
>NZ_CP018822.1|WP_012962119.1|1463061_1465230_+|LTA-synthase-family-protein
MKKLKQVISHVLNTRLGFILTLLFMYWLKTMWAYHVDFSLDLGNLYQVFLSIINPIPLGLLLLGLSLYIKRTRVFYAVSWIIYTILNILLIANAIYFREFSDFITVSAMLASSKVSAGLGDSALNLLRVWDIVYIFDYIILIILFATKKIKTDKRPFNKRASFAITALSALLFSINLFMAEIDRPELLTRGFSNVYVVRALGLPSFTVYSANQTYQAEKERSEATADDLTEVKEYVSEHYAAPNSKYYGIAQGKNVIVIHLESFQQFLIDYKLEVDGQSYEVTPFLNSLYHSNSTISFSNFFNQVKAGKTSDAETLMETSLFGLSSGSYMVNYGGDNTAFAAPSILAQTGGYTSAVFHGNVGSFWNRNNTYKQWGYDYFFDSSYFQEQTDENSFQYGLNDKYMFADSIKYLEHLQQPFYTKFITVSNHYPYTSLAGESDEEGFPLAQTDDETINGYFATANYLDSAIEAFFNYLKESGLYDNSIIVLYGDHYGISNSRNTSLAPLLGKDSETWTEYDNAMLQRVPFMIHIPGYTDGFISDTYGGEVDALPTLLHLLGVDTSNYVQLGQDLLSEDNDQTVALRTAGYYITPTYTSYSGHLYYTATGEEITNPDESTTAATKEIRNAVAKQLSVSDEVQTGDLLRFDTDTGLETVDSSSISYSDSLKSLKSIEKKLGDESTSLYSENGNQSTVDLFKAPSYMQLHSSSSSSSSSSSSSSSSDGS
>NZ_CP018822.1|WP_077497020.1|1461763_1462927_-|class-I-SAM-dependent-rRNA-methyltransferase
MNKLYVDSFVEKKIKRGIQLLDGRDFHQLDFDNQLVAVYNHSHQFLGTAYLSQQNKGIGWFLGSRKIELTESYFVDLFTKAKKQRQNFENSDLTTAYRLFNQDGDNFGGVTIDRYADFVVFSWYNTFIYQYRDVIINAFQKVYPAIKGDYEKIRFKGLDYESAHIYGQEAPASFTILENGVKYSVFMNDGLMTGIFLDQHDVRDTLINELGLGKRVLNMFSYTAAFSVAAAMGGAIETTSVDLAKRSRELSQAHFEANGLDLSNHHFVVMDVFEYFKYAKRKQLTFDLIVIDPPSFARNKKQTFSVAKDYHRLISQALEVLSEDGIIIASTNAANLTVAQFKKQLEKGFASVKHDYVRLQQLPSDFTVNKADVNSNYLKVFTIKVKK
>NZ_CP018822.1|WP_077497026.1|1470306_1470888_-|hypothetical-protein
MKKKLRCYLTLLLSLGLLAACSTHSQNNTNQSSSSTTVSSSVKKSTNSSETSTSSTGSSESEEASSTESSPSTEVTLAPINTGAILKADYSTMAGTWQNASGETLTFNDAGLATEGLTADFLDIDQNGILLLDVQTGSKTNVTLYIVPANTSFSSDYLNGQSDNSEVSKDRIISSADISSGDIANKAYYHVSE
>NZ_CP018822.1|WP_077497028.1|1470900_1473873_-|GBS-Bsp-like-repeat-containing-protein
MHLKKNVLRSCLLSPVIIGAFLSSSLVLADENTTISTTAENVQTEQVSSTTENTVADTSVSEAEQATESSSEQPLVEDSDNETTVSENNSSIDSATTDTTDAIVVANESALSETSDNLGANTKAEEVSEDSQTAETSTTTTGAVDEEATEDDNETETLTVNTDTVSEVNTASLTTSLQSTAKKVTSTQTQKSLVEASVSGNTLSVQYNGTITAGESLKFAVWSDNNDQDDLVWYDADASGAAYIDLSNHKDYGIYNIHTYSFKNGQTTGLNAMTVTVARPEVTTNITQTSNGNFTITISNVPDSITSILVPVWSDNNGQDDIKWYSAKQTGTGTYQATVSVANHNSDNGHYSAHIYGQSSITGGLIGLAVTSGFDNVDTRPNATVSVVNYAEDKTTFDVVVTGSSATKTIKSVAIAVWSEDKGQDDLIWYTPTITNNSARVTIDIANHSNTSDIYNVHVYTDYADGTRVGQVLGAYQITKPTPKNDVTATLTSDGIALTLDSNTVTDYSKVKFAVWSDDEGQDDLVWYDASSAGTALASYENHSGYGTYHIHTYSFETGKAVGLNATDIVIEKPNVQTTITKVDDNTYKVTVTNVPIYIKSVSLPVWSTVNGQDDIDWLTATKEDSSTYTGTISLKDHHYDSGDYNVHVYGQSKLGNQFIGLAVTKGFTVTETSATAPTITVSNYDKDSGVLTVTVSETSTSKQLKFIRVAAWSESDQSNLYWYTTSDITNGTASLTVDEKYHDYIKGDYTVHVYVDFSDGTTSGYNLGSYTFNADQPVQQESSYFIDISSHNGVISVSEFLSLKSQGITGVVVKLTEGTSYTNPYASSQISNAQAAGLKVSAYHYSHYETAAEAKAEAQYFVSVAKSLGLSSSTVMVNDMESSEMLNGDINANTQAWKEEMTRLGYSDLVYYTMASWLDIKGGKVSTSTFGMSNFWVAHYVYGYTYLDQETAKSLAYYSSAAAWQYTSVSPKLSHALDENIDYTGRFTW
>NZ_CP018822.1|WP_077497030.1|1473988_1475329_-|GBS-Bsp-like-repeat-containing-protein
MSKLKTALLSTVVLGATCLSHPIFADQQGNAIVSKTNFDSASKTFEVTAQQSDNGKAIKGINVAIWSEENGQDDLKWYTNSNVSGGQVKVQFNLANHGNRAGNYITHVYTNYTDGSCSGVALENTKINPKAPQLSVKNGAIQMTTDIYAPSNGQIKYAVWSEENDQDDLRWYEDSGKGITQADLKNHSGYGRYFVHTYLSQGGKMIGINGQDIVINKQEVSYQINKVNDTTYDVLVTNVPEYITSIAVPTWSNANGQDDIKWYTTTKVDNGTYKAKINLANHGYASGDYSVHIYGQNAITNNFEGLKGTSGFRADNVPNQNTTPTPRITTYINETNTYPVGQCTWAVKSLAPWIPNWLGNAGGWATNAKAKGFRTGSTPRVGSIAVWPNDGGGYGHVAYVTDVASNTRIQVKESNYAGNQYIANFRGWFNPLDSFWGGSVTYIYPD
>NZ_CP018822.1|WP_077497032.1|1475411_1477001_-|beta-carotene-15,15'-monooxygenase
MLKKCHDVIINLLHAWSLLLFTLITLISLFYRTFIPRYSELAEIKQNRLFLLILFLALGIFYFVIANLRKSSAKRIFFLGVLAYTIFAIYLFLSVSGILRNDAVAVYDAARGLNNGDFSYLEINSYLYRFPHQLGLVTYERIILALTGAKNAKIFFLLNFIMIIAINYLNWRITKKLFDNEEISKISIVISFIFLPQFFSILFVYGLVPGLFFSMIAIYCLIAYFEKRQLRFLAGLIIALICATVIRNNYIILVVTISIILILDAINHKAFPSFLGIIVLFTMLSAANTSINSHYKNLSNGSDISGTPHIAWIAMGLDDNSKSPRLPGWYDESIDNVYVENKGDFEKIKILSQYKVKERLDYLTGHPKYAWDFFATKVLSTWTEGLFQSIWSGPAPALNQGVRTFLWKSVYNGKFFYKFFSLFSTAILFLIYFGSLVFLFYLVGSQKVVNSLIFYPYIYFSGGFLFHLIWETKSQYAYPYIVLLFPVAAFGLFKFPQLKKTVLWKRIVQKLRLVLFSLSDTIENAKLNK
>NZ_CP018822.1|WP_074581183.1|1477058_1477985_-|glycosyltransferase-family-2-protein
MKKLSIVVPCYNEQETIYPFLEETQKVEQKLKNHLVFDYIFVNDGSKDETLNVLRDVASRFPNVHYLSFSRNFGKEAGLLAGLEAADGDLITVMDADLQDPPELLINMYQKILEGYDVVGTRRADRKGEPVIRSFFSKMFYKIINAVSDTEMVDGARDFRLMTRQVVDSILELGEVNRFSKGIFSWVGYDVTYIAYENRERVAGETSWNFWSLLKYSMEGFINFSEAPLNLSLWAGAVSFLASILGILFIIVRKLTIGGSVTGWASLVCIILFIGGIQLLALGIIGKYISKIFLETKKRPVYIVKEKG
>NZ_CP018822.1|WP_077497034.1|1478103_1479573_-|glucosyltransferase-domain-containing-protein
MKNKVNDFVNLNKQKIFIIFVLYCVSACSIGVVNYPYIDDIARRIEGVGNFAAHYSRYLSEFASYIVQGSHHLTDTGLTTFVVSAIILTLTSVVVLYVMFDGEQISWVSAMGSVFIGINPWFLEPISFRFDAPYICLSVLVSVIPFLFFYSKKRNYFLLSIIGIFLMCNSYQGSSGIYIIMLLTLLYRDFLKGVEISELLKKLLISALAYVISMGVYLLETKLNPELALRGDTTSIAPLKDMPAAVFNNLRVYFITLKSQSTNAWLYLAIVLFIMFFVYMTYSSKINKLISSIFGIIYIALGSILSFGVYMFFSTPLADDRPRYEYGFAYFIAIIMILLGSYSSNKVIDYVKGLVVVLLVYYSVSFAFIYASALDNQKEAFEDSAVMLAEDLNDYVTADNQTVYISSMFKDSPAYLNTLKTYPILDDLIPSNSNLYWPNLLWFNTLTNLNVNLVGFDFNTIDMNTLELLESNKLWDIYQLNGEIYVYTK
>NZ_CP018822.1|WP_077497036.1|1479592_1482061_-|alkaline-phosphatase-family-protein
MMKKFLKSFDWVNLLRIVLLIIFLFYINFYLVNSYVLKGATSDLSLGFQSSLHFSLIAYILSIVGISFYLVKDLSKTFFIKLVSGYFIYQIVSYFILVTRNLNNEKFKVWDLIKNHFFQPNFLVTLLIIIGISGVLYFLIQKNRYLAFIEDYLQDYDSKNTILFGFLASFVVNDRQMLKIFKELVSSYLSDNDYVHFIIHLSSNLALTLMVMGVVSYFVINAYQAIVTNSPTPSLMITVSFALATIFNYTLQLGVRSDETLLDKFIFPGATAYQIIALTCLFLIIYLVFNRFLSATFLIIVTGVIISVVNSIKEGLRSEPLLITDFVWLKEISLLTSFVDKSVIIYIVLGVIATLGVYILLRKRILPGKIFNIKRLRFSFLGALIGLGVFNFIVFRNETDSKIIDNIPVVSKVNNWVDINWMGFSTNASYKSLTYVWTKQLTKSVMETPDGYSEEKIKELAEKYRNEASIINASRANKIEDQTVIFILSESFSDPSRVPGVTLSENVIPNITQIKDEYTSGLMISDFYGGGTANMEIQALTGLSYSNLSPSVSVMNTEVLPKMSYIPSISDSYTDDEKIAVHLHNGANYSRNIVYKDLGFDTFIALDGTDDKPTQLEYLSAGARDSSTYYAVTSNLSSDTSQFFSVITMQNHIPWEAEEPAEITAYGEGLSDEENESLTSYARLLNITDSATADFLNELSGYDKKITVVFYGDHLPGLYPTSIFSSDPLNQYETDYFIWSNYETEKLSYPSVNSSDFPALVLKQTDSKVSPYYALLTDILEAENQSSDDLEALSMDLQMLQYDLTLGKSYITKVDEKFFETE
>NZ_CP018822.1|WP_077497038.1|1482057_1483818_-|alpha-L-Rha-alpha-1,3-L-rhamnosyltransferase
MKRLLLYVHFNKYNKISEHVYYQLEHMHPLFSKVIFISNSQLDEGEVDKLRQSQLIDAFIQRENIGYDFAAWHDGMAFEGFENLKAYDSVTAMNDTCFGPLWDMAPVYDKYESDEKVDFWGMTNHRAIDAGHIYIDEHLQSYFMSFKKSIVISEVFQEFWKSVEAYADVQKVIDNYETKYTKRFVDAGFRYASVLNTVPIADNFFHSNFTIHYPHVLLDNHVPFIKIKTFDLTQHLAPYLLKEIEKVSNYPTKLILDHMSDISLPTPPYLLDRKVLKVVEKEYSNTKKVAVHLHTFYVDLLEEFLNQFENFHFDYDLFLTTDTEAKKAEIESILEKNGKIAQVFLTGNRGRDIIPMLKLKEELSSYDYIGHFHTKKSPEYPYWVGDSWRNELYQMLIQSADNILANLENNDNLGLVIADIPSFFRYTKIVDPWNENRFADGMNELWERMNLGRQIDFNNLSTFIMSYGTFIWFKRDTLKPLFDLELTDDEIPSEPIPQHTILHSIERILVYLAWANNYDYAIAKNDIYITPFVDNVVFNIRPNTMPNTYVNFDNIGGIKGALKYIYRGPGSAIKYIIKRMVLKFKS
>NZ_CP018822.1|WP_077497040.1|1483814_1485161_-|glycosyltransferase
MMDALVSIVVTCYNHESYVKDCLESIFQQTYKNIELLVFNDGSLDDSDTVIKDTLSLSPFENTQYFYHENKGVVLTRNIALEHVSGDYLVFVDSDDTLKKDYIRLLVETAEKENADIVYSALYELNSGEVVLPIKEYDLQEMFIGNFIHASSLIRTSAIGNIKFDEQLNREKLEDYDFYLNLVTSKELKVVPCYATGLNYRMSFDSRSSHQNLKSYYKTYGYIIGKYLTRFPNYVKEALDYHFERLTSLDIEHSIKEEKISIYFSENEAFSDIPDYQNQIQFQDEIEIPVVKGKNYIRIRPSNIPSFYEFFVLKSKEYQTEILPIMSNGLIDENSVVFEDFYPFLDYQFTLSEGDKLVLSYKRYNINDIVAKDYIGKLLAKQKYNRLQTILSYEQKQRQLESELNQKTQEFDDLSKEYNTLLSNYRSITNSIWWKIPTKIINFFRRKK
>NZ_CP018822.1|WP_009854474.1|1485157_1486357_-|ABC-transporter-ATP-binding-protein
MSDKKIAVKVDHVSKYFKLPTEATQSLRTNLVNYFKGIKGYREQHVLKDIDFEVEEGDFFGIVGRNGSGKSTLLKIISQIYVPEKGKVTVNGKMVSFIELGVGFNPELTGRENVYMNGAMLGFTTEEVDAMYDDIVEFAELEDFMNQKLKNYSSGMQVRLAFSVAIKAQGDVLILDEVLAVGDEAFQRKCNDYFLERKTSGKTTILVTHDMGAVKKYCNKAILIEDGYIKAQGEPDEVANQYSYDNANTEKNDDGKTVEKLVVDNLEVNLLSSGQTTPDKPIEFSISYNVLEDLETYVAFSLTDIDRNIWIYNDNSMEYLSSGKGYKHATYSCLLNNVNNLKLKLEVSIRDKNGKMLAFANSSNTNVILVSRNDLALDDKSGRDSATGLIQRNGTWKFK

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Crispr_ID: NZ_CP018822_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018822_2

1661343-1661705

TypeII

II-A

Consensus_repeat	Method
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC	CRT

5 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP018822_2

>merge|NZ_CP018822|2|1661343-1661705|CRT
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAACAAATCGTTGCGTAAAATGAAAAACAAACAGTTTTGGAACCATTCGAAACAGCACAGCTCTAAAACAAATCGTTGCGTAAAATGAAAAACAAACAGTTTTGGAACCATTCGAAACAGCACAGCTCTAAAACAAATCGTTGCGTAAAATGAAAAACAAACAGTTTTGGAACCATTCGAAACAGCACAGCTCTAAAACCTGGGTCGCAAGCACCTCGGGCTTGCTGCGGTTTTGGAACCATTCGAAACAGCACAGCTCTAAAACAGACCACCGAGTGGCTGTCCAAGCAGCTCGGTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC

>NZ_CP018822|2|1|1661343-1661705|CRT
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC	AAATCGTTGCGTAAAATGAAAAACAAACA
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC	AAATCGTTGCGTAAAATGAAAAACAAACA
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC	AAATCGTTGCGTAAAATGAAAAACAAACA
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC	CTGGGTCGCAAGCACCTCGGGCTTGCTGCG
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC	AGACCACCGAGTGGCTGTCCAAGCAGCTCG
GTTTTGGAACCATTCGAAACAGCACAGCTCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018822.1\|WP_099046290.1\|1652293_1652467_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018822.1\|WP_174564805.1\|1662512_1663178_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_CP018822.1\|WP_009854536.1\|1662228_1662417_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_CP018822.1\|WP_077497286.1\|1655014_1656457_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|224235
NZ_CP018822.1\|WP_077497294.1\|1661836_1662217_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|374224
NZ_CP018822.1\|WP_009854538.1\|1663164_1663509_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP018822.1\|WP_014294902.1\|1657364_1657841_-\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
NZ_CP018822.1\|WP_077497304.1\|1671097_1671985_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP018822.1\|WP_077497282.1\|1651478_1652297_-\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|369151
NZ_CP018822.1\|WP_077497292.1\|1659338_1661174_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP018822.1\|WP_157769867.1\|1672292_1673507_-\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NZ_CP018822.1\|WP_077497300.1\|1664371_1668526_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_CP018822.1\|WP_009854526.1\|1654622_1654856_-\|AbrB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225215
NZ_CP018822.1\|WP_077497306.1\|1672085_1672289_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP018822.1\|WP_077497302.1\|1668800_1671092_-\|alpha-xylosidase	unknown	unknown	gnl\|CDD\|236731
NZ_CP018822.1\|WP_077497290.1\|1657833_1659117_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NZ_CP018822.1\|WP_077497284.1\|1652678_1654040_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_CP018822.1\|WP_077497288.1\|1656543_1657368_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NZ_CP018822.1\|WP_061459083.1\|1654230_1654626_-\|type-II-toxin-antitoxin-system-death-on-curing-family-toxin	unknown	unknown	gnl\|CDD\|226180
NZ_CP018822.1\|WP_077497298.1\|1663505_1664372_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Function_ID	Function_description	E-value
NZ_CP018822.1\|WP_009854538.1\|1663164_1663509_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.71482e-48
NZ_CP018822.1\|WP_174564805.1\|1662512_1663178_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.49601e-115
NZ_CP018822.1\|WP_009854536.1\|1662228_1662417_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	8.16808e-15
NZ_CP018822.1\|WP_077497286.1\|1655014_1656457_-\|LCP-family-protein	gnl\|CDD\|224235	COG1316, LytR, Transcriptional regulator [Transcription].	4.11668e-55
NZ_CP018822.1\|WP_077497294.1\|1661836_1662217_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	5.35551e-17
NZ_CP018822.1\|WP_014294902.1\|1657364_1657841_-\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	8.13446e-60
NZ_CP018822.1\|WP_077497304.1\|1671097_1671985_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	7.14715e-58
NZ_CP018822.1\|WP_077497282.1\|1651478_1652297_-\|replication-initiator-protein-A	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	2.60612e-33
NZ_CP018822.1\|WP_077497292.1\|1659338_1661174_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP018822.1\|WP_157769867.1\|1672292_1673507_-\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	4.61437e-54
NZ_CP018822.1\|WP_077497300.1\|1664371_1668526_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_CP018822.1\|WP_009854526.1\|1654622_1654856_-\|AbrB-family-transcriptional-regulator	gnl\|CDD\|225215	COG2336, MazE, Growth regulator [Signal transduction mechanisms].	7.60191e-05
NZ_CP018822.1\|WP_077497306.1\|1672085_1672289_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	3.00496e-15
NZ_CP018822.1\|WP_077497302.1\|1668800_1671092_-\|alpha-xylosidase	gnl\|CDD\|236731	PRK10658, PRK10658, putative alpha-glucosidase; Provisional.	0
NZ_CP018822.1\|WP_077497290.1\|1657833_1659117_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	0
NZ_CP018822.1\|WP_077497284.1\|1652678_1654040_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	9.34899e-180
NZ_CP018822.1\|WP_077497288.1\|1656543_1657368_-\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	5.0373e-151
NZ_CP018822.1\|WP_061459083.1\|1654230_1654626_-\|type-II-toxin-antitoxin-system-death-on-curing-family-toxin	gnl\|CDD\|226180	COG3654, Doc, Prophage maintenance system killer protein [General function prediction only].	2.90897e-28
NZ_CP018822.1\|WP_077497298.1\|1663505_1664372_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	7.13504e-130

>NZ_CP018822.1|WP_077497292.1|1659338_1661174_-|elongation-factor-4
MDIQELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFSYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRQEIEDVIGLDASEAVLASAKAGIGIEEILEQIVEYVPAPAGDVEAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQLMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTVTLAENPAEAPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTKVASIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDENRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRKSKLVKMDILLNGDKVDALSFIVHSEFAYERGKLIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDNSKK
>NZ_CP018822.1|WP_077497290.1|1657833_1659117_-|3-phosphoshikimate-1-carboxyvinyltransferase
MKLLTNVSQLKGTLRVPGDKSISHRSIMFGSLAKGTTTVHDILRGEDVLSTMQVFRDLGVDIQDDGNIVTITGVGFDGLKAPKNKLDMGNSGTSIRLISGVLAGQDFTVEMFGDDSLSKRPMDRVTIPLRQMGVEVSGQTDRDLPPLTMRGSKALKPIHYQLPVASAQVKSALIFAALQADGESVIIEKEKTRNHTEDMIVQFGGAIDVNDKEIRIKGGQEFTGQDVVVPGDISSAAFWLVAGLIVPNAKVILENVGINETRTGIIDVIKEMGGKMTISNVDEIAKSATITVETSELHSVEIGGEIIPRLIDELPIIALLATQANGTTIIRDAEELKVKETDRIQVVADALNAMGADITPTDDGMIIKGKTPLHGAKVNTFGDHRIGMMTAIAALLVSDGDVELERAEAINTSYPSFFNDLEVLSRG
>NZ_CP018822.1|WP_014294902.1|1657364_1657841_-|shikimate-kinase
MARIIIGFMGSGKSTISSLLDKNYIDMDALITERIGMSIADFFAKEGEAKFREIESQVLAELADSDQVISTGGGVVINPINREILAKNPETIYLKSDFETLYDRIEHDTENVRPLFVNNSKEAFKEIFDGRQEMYEAAANRIIDVAGKTPEEIVEEIG
>NZ_CP018822.1|WP_077497288.1|1656543_1657368_-|prephenate-dehydratase
MKVGYLGPSGSFTHNVAVKAFPEANRMPFANITEVIKSYEEGFVDYAIIPVENSIEGSVHETLDYLFHQAEIEAIAEIIQPIKQQLLATTQTKKIEKIFSHPQAIAQGKKYIKAHYPAAKIEMTASTAYAARFIAEHPEENFAAIAPVAAAKEYGLDIIAQDIQEMDENYTRFWVLGHQKRSFDLAKLNQKVSLALTLPDNLPGALYKALSVFAWRGIDLTKIESRPLKTALGEYFFIVDVENKNDTLVSFALEELSVLGIGYKILGRYDVYKL
>NZ_CP018822.1|WP_077497286.1|1655014_1656457_-|LCP-family-protein
MARSNLSRHEELRYEYLLSNLEYLSAREKQEFDYLYNKKQASEVSEPPRSQPSSAYNDNYYDDYYDDAYDNQVDYYDDDNWTSQGLPKYPEEKKQPKRSFRRTSEQQAEILPTYQDNYENYDEAFYQEPEPVTPKKAKKPKKKRRRIRIKRLLKLLGFLVILVMAGMIYMFFKGINDVSSGETNYTAAVTETFNGEDSDDGTNILILGSDQRITQGSSDARTDTIMVMNIGNSDGKIKLVSFMRDTLVNIDGVSYNAYSNDQKLNVAFNIGEQDDNQGAELMRQTLKDNFDINIKYYVMVDFETFAEAIDTLFPNGVEIDAKFGTVDGQAVSSVEVPDDLNMQADGTVPNQTIEVGTQKMDGRTLLNYARFRKDDDGDYGRTQRQQQVISAIINQIKDPSKLFTGSAAIGKIYALTSTNISYPFLLKEGLSVITSGQEGIEQTTIPAEGDWTDDYDMYGGLGIAIDFDKYQEELKELGLR
>NZ_CP018822.1|WP_009854526.1|1654622_1654856_-|AbrB-family-transcriptional-regulator
MIVKSRKQGNSLMITIPSYLNVPEGTEYEVKASANGELIFSPVEKSKREFATNEDISAITDDIFKDYDDVFKELVDK
>NZ_CP018822.1|WP_061459083.1|1654230_1654626_-|type-II-toxin-antitoxin-system-death-on-curing-family-toxin
MTKYLTEEQLVSINKMVIEKYSPLENSRLVSPSALNMIVNLPEQYVFGKELYPTLMEKATVLFVQLIKKHVFENANKRTAVFALVAFLKLNQIKLMVSTKELVDFTVLIATNPLTDDSFKEYCEWLNERVD
>NZ_CP018822.1|WP_077497284.1|1652678_1654040_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MLSKNAIVDAEITDLSHEGAGVAKVDGFVFFVENALPGEKIKMRVLKVKKNIGFGKVEEYVTISEHRNQDLNVDYLRTGIADFGHLAYAEQLKFKRKQVMDNLYKTAGISDIEVSETLGMAHPYAYRNKAQVPVRRVNGQLETGFFRKHSHDLMPISDYYIQNKEIDRLINFTRDLLRRFDLKPYDEKEQTGLIRNLVVRRGHYSGEMMLVFVTTRPKIFRIEQIIEKIVAEFPAVKSIVQNINDKNTNAIFGNEFKTLYGKDTIIDSMLGNQYEISARSFYQVNTEMAERLYQTAIDFSDLTPEDIVIDAYSGIGTIGLSFAKNVKAVYGVEVIEEAVKDAKRNAALNGITNAHYVADSAEHAMATWSKDGIKPSVILVDPPRKGLTENFIKASVAMQPEKITYISCNPATMARDIKLYQELGYKLIKVQPVDLFPNTHHVECVVLLQRSNG
>NZ_CP018822.1|WP_099046290.1|1652293_1652467_-|hypothetical-protein
MQKKEQSSRQIVMCHLVTILGVDIEKATQLVDEMEQVGLIRFDEFGNVGLLVLEGQS
>NZ_CP018822.1|WP_077497282.1|1651478_1652297_-|replication-initiator-protein-A
MKRITANQYQTSERYYKLPKVLFESERYKDMKLEVKVAYAVLKDRLELSLSKGWIDEDGAIFLIYSNSNLMALLGCSKSKLLSIKKTLREYGLIDEVQQSSSEKGRMANKIYLGELEHEPNPVLDSNGASVKKTPGGSQRKTGPVLNSAPSETEGSKTKYSETEGSDFIIEDEEERQLVDGKQEENFSSKVDAVTKYDRDYIWGLVHDQLRQTGLSQSASDYAMIYFSERYQYALEHMRFARSAEVIAEYVFNGVLSEWTKQLRRQEAKGGD
>NZ_CP018822.1|WP_077497294.1|1661836_1662217_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVDMSELSVEDGFITLIQADPSPYLKSTKAIRKNVTVPEWLVRLADREHVNYSEVLTQALEKKLQL
>NZ_CP018822.1|WP_009854536.1|1662228_1662417_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL
>NZ_CP018822.1|WP_174564805.1|1662512_1663178_-|type-II-A-CRISPR-associated-protein-Csn2
MMKINFPILDEPIEILDATILTVEDVTVFSNLVRQFYSYSEECDLKLFDEKLRSLKVSELLLVTDIFGFDVNSQSMLKLIHADLESQLNDKPEVKSMIEQLANTITELLSYECLENELDLEYDEITILELIKALGVKIETQSDTIFEKCFEILQIYNYLSKKKLLIFVNSGAYLTKNEMEKLIEYIKLSNQKVLFLEPRKLYDFPQYVLDSDYFLIAENMN
>NZ_CP018822.1|WP_009854538.1|1663164_1663509_-|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTETAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNSANKAMIDRLQANNPKKGSITLLTVTEKQFARMIYLNGERNTSVANSDRRLVFLGEDYSDEN
>NZ_CP018822.1|WP_077497298.1|1663505_1664372_-|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTVIVNEHSKLSYKNNHLIFKDAYHTEMIHLEEIDILLLETTNIVLTTMLLERLVERNILIIFCDEKRLPTAMLTPYYGRHDSSLQLTNQIAWDDDVKCDVWTTIIAQKILNQSMYLGECSFFEKSQSIMELYHGLEPFDPSNREGHSARIYFNTLFGNDFSREQDNDINAGLDYGYTLLLSMFARELVVCGCMTQFGLKHANQFNQFNLASDIMEPFRPIVDRIVYENRNASFVKIKRELFTMFDETYSYNHKEMFLNNIVSDYTKKVVKALNHGGKGVPEFRI
>NZ_CP018822.1|WP_077497300.1|1664371_1668526_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKKSYSIGLDIGTNSVGWAVITDDYKVPAKKMRVLGNTDKRYIKKNLLGALLFDSGETAEATRLKRTARRRYTRRKNRLRYLQDIFTEEMAKVDDSFFQRLDESFLTDDDKNFDSHPIFGNKAEEDAYHQKFPTIYHLREYLADSSEKADLRLVYLALAHIIKYRGHFLIEGKLNAENTDVQKLFTDFVGVYDRTFDDSHLSEITVDAASTLTEKISKSRRLENLIKYYPTEKKNTLFGNLVALALGLQPNFKTNFKLSDDAKLQFSKDTYEEDLEELLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKANKSELYHEIFKDETKNGYAGYIKNGVKQDVFYKYLKNTLLKMGGSDYFLDKIEREDFLRKQRTFDNGSIPHQIHLQEMHAILRRQGDYYPFLKENQDRIEKILTFRIPYYVGPLVRKDSRFAWAEYRSDEKITPWNFDKVIDKEKSAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVNEQGKESFFDSNMKQEIFDHVFKENRKVTKEKLLNYLNKEFPEYRIKDLIGLDKENKSFNASLGTYHDLKKILDKAFLDDKVNEEVIEDIIKTLTLFEDKDMIHERLQKYSDIFTADQLKKLERRHYTGWGRLSYKLINGIRNKENNKTILDYLIDDGSANRNFMQLINDDTLPFKQIIQKSQVVGDVDDVEAVVHDLPGSPAIKKGILQSVKIVDELVKVMGDNPDNIVIEMARENQTTNRGRSQSQQRLKKLQNSLKELGSNILNEEKPSYIEDKVENSHLQNDQLFLYYIQNGKDMYTGDELDIDHLSDYDIDHIIPQAFIKDDSIDNRVLTSSAKNRGKSDDVPSLDIVRARKAEWVRLYKSGLISKRKFDNLTKAERGGLTEADKAGFIKRQLVETRQITKHVAQILDARFNTESDENDKVIRDVKVITLKSNLVSQFRKDFEFYKVREINDYHHAHDAYLNAVVGTALLKKYPKLASEFVYGEYKKYDVHKLIAKSSDDHSEMGKATVKYFFYSNLMNFFKTKVKYADGRVFERPDIETNADGEIVWNKQTDFEKVRKVLSYPQVNIVKKVETQTGGFSKESILPKGDSDKLIPRKTKKVYWDTKKYGGFDSPTVAYSVFVVADVEKGKAKKLKTVKELVGISIMERSFFEENPVEFLENKGYHNIREDKLIKLPKYSLFEFEGGRRRLLASVRTSDNKKGELQKGNEVVLPQYMVDLLYHANKVKTTKGLEHLEYLVKHKQEFEDLFNLILRIARINILKTKVVDNLINEFTDYDEEGIIALSESFINLLKFTSFGAPGAFKFLKLEVKQSNLRYESITEILNATLIHQSITGLYETRIDLSKLGEE
>NZ_CP018822.1|WP_077497302.1|1668800_1671092_-|alpha-xylosidase
MKFLNGGWLVKDGYEVKYATHLYDYRVEPNRLTVYMPYSYVAHKGATLDGGLMTMEIFTPREEIIGVKIYNHKGQVKKAPQFELSTEKVASQIFDNEEQLTLTSDDLSISISKGEQLTVEFAYKGKVIAQSLPRSKAYITDDKKVAHVSEQLTIDVGEKIYGLGERFTNFVKNGQTVDIWNEDGGTGTEQAYKNIPFYVSNKGYGVFVNSSDKVSFEVGSEKVSRVQFSVPGESLEYYVIAGDSMKDVLGHYTDLTGKPSLPPAWTFGLWLSTSFLTDYDEATVNSFVDGMIERDIPLEVFHFDCLWMKEYEWCNFEWDDRTFPDPVNMLKRLKEKGLKICVWINPYIGQKSPLFDEGAEHGYFLKKANGDIWQWDKWQAGMAIVDFTNPEACQWYESKLKNLLDMGVDCFKTDFGERIPTDTVYYNHADPAKMHNYYAYLYNEVVFNLLKRERGDKEAVVFARSASVGSQKFPVHWGGDSTSDYPSMAESLRAGLSFGLGGFGYWSHDISGFEAGANPDLYKRWTQFGLLSSHSRYHGSWEYKVPWLYGDEAVDVTRAFTKLKLSLMPYLQKEAVQTSQSGVPMMRAMVLEFPKDLATHDLDQQYMLGESLLVAPIFNDKGQKDFYVPNAGGAWIDLLTDKAYSAGQWYQENFDYFHLPVLVRPNSILVRKEAVNRAEYDYNQQVTVHVYNLEDGKTAQTAIFDTQGQKAATIKISRKGGDYHLETTGLIDALLHIHYIDDDKVKHYKTALKDNPQTITLNA
>NZ_CP018822.1|WP_077497304.1|1671097_1671985_-|ROK-family-protein
MPYFCIDVGGTMVKYALLDEHEAVLEHDEIPTQKESKEAFIHSLSKLINPYLTSFEIKGIGISFPGHIVPETGVALQAGAIGVLSGCNVIDLVRQELSQPDIPIIIENDANCAAIAEAYSGRGQDCDDFCLITIGTGIGGAFVHDKKVVHGHSYKAGELGMMIIDYQESGYQTLHDLASTSALVKQYKVLKGLPSEETIHGAAIFEDNDLAVKRLIQEWSTRLAITIFNVVCQNDPDKVLLGGGISRNPHLLPYILLALAKNPFWETFEVPIEICQHQNLAGLLGAYHLLKEKGE
>NZ_CP018822.1|WP_077497306.1|1672085_1672289_-|AraC-family-transcriptional-regulator
MDESFLNYLEKVRMEKATDLLKESHLMVYEIADKVGYNNIDYFYKKFKHFYHISPNEYRRQIAQKSK
>NZ_CP018822.1|WP_157769867.1|1672292_1673507_-|response-regulator
MKKVLIVDDEKIIREGLKYLIDWENYGFSVVAMASNGKEGLQAIETYHPDLVITDIKMPEQTGLEMVQTAKERLDYPFYSIILSGYSEFEYAQQAVSLGFTSYLLKPVDEDELIAVLKTIQEETAKLDENDFEKRLFDKIFGTDKTGLTDYQFINCSRFDQAIPVDILEQLEELPLKYVVLNNLSKYYLILLTTAPLNQDVYQFTKICANRGKIISTGWVSAKQDLTVIPKQLNDLSEAAFMFPNQLILPEKITRMSPEIMIPVTLDDLVSKIIATNDLTTVVMAYGRSLCADYYLKDDLIWKMRHDYATILDKIKEKLQKSIAVDESAFCEKARQADSYPELITLFKEELEKLSRQIAEEFNNIDIIDQLIYYVDRHYEEDLTLKDIADHFGYNSAYLGKKFK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018822_1	1.1\|1470212\|26\|NZ_CP018822\|CRISPRCasFinder	1470212-1470237	26	MT684590	Streptomyces phage LilMartin, complete genome	116452-116477	5	0.808
NZ_CP018822_1	1.1\|1470212\|26\|NZ_CP018822\|CRISPRCasFinder	1470212-1470237	26	MT897905	Streptomyces phage MulchMansion, complete genome	118086-118111	5	0.808
NZ_CP018822_2	2.1\|1661379\|29\|NZ_CP018822\|CRT	1661379-1661407	29	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	301194-301222	6	0.793
NZ_CP018822_2	2.2\|1661444\|29\|NZ_CP018822\|CRT	1661444-1661472	29	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	301194-301222	6	0.793
NZ_CP018822_2	2.3\|1661509\|29\|NZ_CP018822\|CRT	1661509-1661537	29	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	301194-301222	6	0.793
NZ_CP018822_2	2.4\|1661574\|30\|NZ_CP018822\|CRT	1661574-1661603	30	NZ_CP031079	Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence	412046-412075	6	0.8
NZ_CP018822_2	2.4\|1661574\|30\|NZ_CP018822\|CRT	1661574-1661603	30	NZ_CP044079	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence	9304-9333	6	0.8
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	MN428050	Mycobacterium phage Apex, complete genome	48667-48696	8	0.733
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	MT897910	Mycobacterium phage VioletZ, complete genome	48557-48586	9	0.7
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	MT818419	Mycobacterium phage Lolalove, complete genome	48463-48492	9	0.7
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	MT639648	Mycobacterium phage Heath, complete genome	48069-48098	9	0.7
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	NC_042034	Mycobacterium phage ChrisnMich, complete sequence	47429-47458	9	0.7
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	NC_011044	Mycobacterium phage Nigel, complete genome	48437-48466	9	0.7
NZ_CP018822_2	2.5\|1661640\|30\|NZ_CP018822\|CRT	1661640-1661669	30	KF493881	Mycobacterium phage JAMaL, complete genome	48621-48650	9	0.7

1. spacer 1.1|1470212|26|NZ_CP018822|CRISPRCasFinder matches to MT684590 (Streptomyces phage LilMartin, complete genome) position: , mismatch: 5, identity: 0.808

cgagtcttgaaattaatgaacgagtt	CRISPR spacer
ccagtcttgaaattaatgaacttctc	Protospacer
* *******************   *.

2. spacer 1.1|1470212|26|NZ_CP018822|CRISPRCasFinder matches to MT897905 (Streptomyces phage MulchMansion, complete genome) position: , mismatch: 5, identity: 0.808

cgagtcttgaaattaatgaacgagtt	CRISPR spacer
ccagtcttgaaattaatgaacttctc	Protospacer
* *******************   *.

3. spacer 2.1|1661379|29|NZ_CP018822|CRT matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.793

aaatcgttgcgtaaaatgaaaaacaaaca	CRISPR spacer
aatggtttgcgtaaaatgaaaaacagact	Protospacer
**    *******************.**

4. spacer 2.2|1661444|29|NZ_CP018822|CRT matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.793

aaatcgttgcgtaaaatgaaaaacaaaca	CRISPR spacer
aatggtttgcgtaaaatgaaaaacagact	Protospacer
**    *******************.**

5. spacer 2.3|1661509|29|NZ_CP018822|CRT matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.793

aaatcgttgcgtaaaatgaaaaacaaaca	CRISPR spacer
aatggtttgcgtaaaatgaaaaacagact	Protospacer
**    *******************.**

6. spacer 2.4|1661574|30|NZ_CP018822|CRT matches to NZ_CP031079 (Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence) position: , mismatch: 6, identity: 0.8

ctgggtcgcaagcacctcgggcttgctgcg	CRISPR spacer
cagtgccgcaagcacctcggccttgttgcc	Protospacer
* * *.************** ****.***

7. spacer 2.4|1661574|30|NZ_CP018822|CRT matches to NZ_CP044079 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

ctgggtcgcaagcacctcgggcttgctgcg	CRISPR spacer
cagtgccgcaagcacctcggccttgttgcc	Protospacer
* * *.************** ****.***

8. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to MN428050 (Mycobacterium phage Apex, complete genome) position: , mismatch: 8, identity: 0.733

agaccac---cgagtggctgtccaagcagctcg	CRISPR spacer
---ccctgcgcgactggctgtccaagcagctgc	Protospacer
   ** .   *** *****************

9. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to MT897910 (Mycobacterium phage VioletZ, complete genome) position: , mismatch: 9, identity: 0.7

agaccaccgagtggctgtccaagcagctcg	CRISPR spacer
cgctgcgcgactggctgtccaagcagctgc	Protospacer
 * .   *** *****************

10. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to MT818419 (Mycobacterium phage Lolalove, complete genome) position: , mismatch: 9, identity: 0.7

agaccaccgagtggctgtccaagcagctcg	CRISPR spacer
cgctgcgcgactggctgtccaagcagctgc	Protospacer
 * .   *** *****************

11. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to MT639648 (Mycobacterium phage Heath, complete genome) position: , mismatch: 9, identity: 0.7

agaccaccgagtggctgtccaagcagctcg	CRISPR spacer
cgctgcgcgactggctgtccaagcagctgc	Protospacer
 * .   *** *****************

12. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to NC_042034 (Mycobacterium phage ChrisnMich, complete sequence) position: , mismatch: 9, identity: 0.7

agaccaccgagtggctgtccaagcagctcg	CRISPR spacer
cgctgcgcgactggctgtccaagcagctgc	Protospacer
 * .   *** *****************

13. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to NC_011044 (Mycobacterium phage Nigel, complete genome) position: , mismatch: 9, identity: 0.7

agaccaccgagtggctgtccaagcagctcg	CRISPR spacer
cgctgcgcgactggctgtccaagcagctgc	Protospacer
 * .   *** *****************

14. spacer 2.5|1661640|30|NZ_CP018822|CRT matches to KF493881 (Mycobacterium phage JAMaL, complete genome) position: , mismatch: 9, identity: 0.7

agaccaccgagtggctgtccaagcagctcg	CRISPR spacer
cgctgcgcgactggctgtccaagcagctgc	Protospacer
 * .   *** *****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

467866 : 518348

Streptococcus_phage(60.0%)

terminase,capsid,tail,head,integrase,bacteriocin,portal

attL 461178:461193|attR 510610:510625

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
461178:461193	attL	NA	NA	NA	NA
WP_077496251.1\|467866_468169_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_013642717.1\|468184_468919_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.5e-30	30.7
WP_077496253.1\|468923_470549_+	ABC transporter permease	NA	NA	NA	NA
WP_077496255.1\|470606_472460_-	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_009853475.1\|472595_473555_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_174564798.1\|473602_475039_+	6-phospho-beta-glucosidase	NA	NA	NA	NA
WP_013642721.1\|475147_475951_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	2.8e-43	38.9
WP_077496257.1\|475965_477216_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.3e-111	55.0
WP_077496259.1\|477342_478317_+	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	NA	NA	NA	NA
WP_009853480.1\|478319_478643_+	cell division protein FtsL	NA	NA	NA	NA
WP_009853481.1\|478652_480917_+	penicillin-binding protein	NA	NA	NA	NA
WP_009853482.1\|480923_481937_+	phospho-N-acetylmuramoyl-pentapeptide- transferase	NA	NA	NA	NA
WP_009853483.1\|482135_483479_+	DEAD/DEAH box helicase	A0A0N9Q9J4	Chrysochromulina_ericina_virus	2.7e-43	27.5
WP_077496261.1\|483664_484489_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_013642728.1\|484563_485367_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_009853486.1\|485366_486110_+	amino acid ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	1.8e-12	26.3
WP_009853487.1\|486200_486425_+	DUF4059 family protein	NA	NA	NA	NA
WP_012961466.1\|486488_487403_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	1.6e-87	52.1
WP_077496263.1\|487701_488862_-\|integrase	site-specific integrase	A0A141E0Q7	Streptococcus_phage	3.8e-78	41.6
WP_077496265.1\|489043_489709_-	NYN domain-containing protein	A0A0R6PGY5	Moraxella_phage	4.9e-46	46.5
WP_077496267.1\|489974_490769_-	hypothetical protein	NA	NA	NA	NA
WP_033152430.1\|490796_491000_-	hypothetical protein	O34033	Streptococcus_phage	1.5e-09	42.2
WP_077496269.1\|491062_491845_-	helix-turn-helix domain-containing protein	M1PKS2	Streptococcus_phage	2.6e-78	62.6
WP_077496271.1\|492091_492781_-	DUF4145 domain-containing protein	A0A1X9I6S1	Streptococcus_phage	2.3e-99	76.9
WP_077496273.1\|492836_493046_+	helix-turn-helix transcriptional regulator	B3GVX4	Streptococcus_phage	7.7e-14	66.7
WP_157769857.1\|493258_493408_+	hypothetical protein	NA	NA	NA	NA
WP_157769858.1\|493407_493584_+	hypothetical protein	A0A1S5S9V5	Streptococcus_phage	5.9e-07	52.0
WP_077496275.1\|493572_494361_-	DUF4393 domain-containing protein	A0A1S5S9V3	Streptococcus_phage	2.3e-103	72.0
WP_099046281.1\|494416_494563_+	hypothetical protein	NA	NA	NA	NA
WP_077496277.1\|494536_494860_-	hypothetical protein	A0A0A8WJ72	Clostridium_phage	1.4e-06	30.3
WP_012961481.1\|494960_495212_+	helix-turn-helix domain-containing protein	A3F618	Streptococcus_phage	1.9e-22	62.4
WP_012961482.1\|495250_495391_+	hypothetical protein	A0A1P8VVR9	Streptococcus_phage	4.0e-06	56.1
WP_077496279.1\|495400_495628_+	hypothetical protein	NA	NA	NA	NA
WP_077496281.1\|495614_496910_+	AAA family ATPase	A0A097BY67	Enterococcus_phage	1.8e-137	59.6
WP_077496283.1\|496929_497265_+	hypothetical protein	A0A1X9I5N1	Streptococcus_phage	9.2e-17	46.8
WP_077496285.1\|497264_498392_+	AAA family ATPase	A0A0K2CZH1	Paenibacillus_phage	6.3e-110	54.3
WP_077496287.1\|498537_499149_+	hypothetical protein	A0A097BY29	Enterococcus_phage	1.0e-29	47.1
WP_077496289.1\|499162_499786_+	hypothetical protein	D2XPY9	Bacillus_virus	4.3e-44	44.4
WP_077496291.1\|499787_501371_+	DEAD/DEAH box helicase family protein	Q5YA94	Bacillus_phage	4.3e-197	65.5
WP_077496293.1\|501387_503661_+	AAA family ATPase	Q5YA88	Bacillus_phage	1.7e-284	64.0
WP_077496295.1\|503948_504200_+	hypothetical protein	NA	NA	NA	NA
WP_077496297.1\|504211_504565_+	hypothetical protein	Q9AZU6	Lactococcus_phage	3.7e-16	42.4
WP_077496299.1\|504561_504957_+	RusA family crossover junction endodeoxyribonuclease	Q5YA86	Bacillus_phage	2.3e-35	53.4
WP_077496301.1\|504953_505175_+	hypothetical protein	NA	NA	NA	NA
WP_167367605.1\|505177_505327_+	hypothetical protein	Q77PS0	Streptococcus_phage	8.0e-05	55.3
WP_077496303.1\|505323_505590_+	hypothetical protein	NA	NA	NA	NA
WP_157769859.1\|505561_505732_+	hypothetical protein	NA	NA	NA	NA
WP_077496305.1\|506104_506518_+	DUF722 domain-containing protein	A0A1X9I5N8	Streptococcus_phage	3.4e-37	57.8
WP_077496307.1\|506958_507879_+	hypothetical protein	NA	NA	NA	NA
WP_157769860.1\|507881_508346_+	hypothetical protein	NA	NA	NA	NA
WP_077496309.1\|508392_508827_+	helix-turn-helix domain-containing protein	A1EAE0	Streptococcus_phage	1.8e-44	66.9
WP_077496311.1\|508823_510215_+\|terminase	terminase	A0A097BY88	Enterococcus_phage	1.3e-144	55.9
WP_077496313.1\|510227_511703_+\|portal	phage portal protein	C9W9H5	Streptococcus_virus	1.8e-133	51.8
510610:510625	attR	NA	NA	NA	NA
WP_077496315.1\|511683_513075_+\|capsid	minor capsid protein	A7J293	Streptococcus_phage	3.3e-100	53.7
WP_077496317.1\|513650_514286_+	DUF4355 domain-containing protein	A0A286QQH5	Streptococcus_phage	9.0e-29	59.7
WP_077496319.1\|514298_514664_+	hypothetical protein	A0A286QPB3	Streptococcus_phage	4.5e-25	50.0
WP_077496321.1\|514667_515714_+\|capsid	major capsid protein	A0A286QR01	Streptococcus_phage	2.2e-109	57.9
WP_012961503.1\|515728_515872_+	hypothetical protein	NA	NA	NA	NA
WP_012961504.1\|515889_516246_+\|head,tail	phage head-tail connector protein	O34064	Streptococcus_phage	6.5e-37	65.5
WP_077496323.1\|516242_516521_+	hypothetical protein	NA	NA	NA	NA
WP_077496325.1\|516517_516862_+	HK97 gp10 family phage protein	A7J2A0	Streptococcus_phage	1.7e-21	47.4
WP_077496327.1\|516869_517229_+	DUF3168 domain-containing protein	A7J2A1	Streptococcus_phage	5.2e-34	65.0
WP_012961508.1\|517243_517822_+\|tail	phage major tail protein, TP901-1 family	A7J2A2	Streptococcus_phage	1.1e-52	60.6
WP_077496329.1\|517883_518348_+	hypothetical protein	A7J2A3	Streptococcus_phage	1.5e-33	51.3

DBSCAN-SWA_2

523428 : 535241

Temperate_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077496333.1\|523428_527889_+	hypothetical protein	A7J2A7	Streptococcus_phage	5.0e-150	59.6
WP_167367607.1\|527910_528084_+	hypothetical protein	NA	NA	NA	NA
WP_077496335.1\|528086_528410_+	hypothetical protein	NA	NA	NA	NA
WP_077496337.1\|528425_528722_+	hypothetical protein	NA	NA	NA	NA
WP_077496339.1\|528718_528916_+	hypothetical protein	Q938J5	Temperate_phage	2.3e-12	59.0
WP_077496341.1\|528905_530183_+	LysM peptidoglycan-binding domain-containing protein	A0A0S2MYF3	Enterococcus_phage	1.4e-145	62.4
WP_077496343.1\|530469_530997_+	DUF4065 domain-containing protein	Q938J3	Temperate_phage	9.0e-67	71.8
WP_077496345.1\|530984_531842_+	hypothetical protein	Q938J2	Temperate_phage	8.6e-59	44.4
WP_077497995.1\|531849_532065_+	hypothetical protein	A3F673	Streptococcus_phage	3.5e-09	63.0
WP_009853551.1\|532219_532828_+	MarC family protein	NA	NA	NA	NA
WP_061459007.1\|533780_535241_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.2e-98	41.6

DBSCAN-SWA_3

1246684 : 1255292

Bacillus_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009854245.1\|1246684_1247605_+	type I pantothenate kinase	A0A1B1ISL9	uncultured_Mediterranean_phage	1.6e-34	33.5
WP_003064878.1\|1247679_1247931_+	30S ribosomal protein S20	NA	NA	NA	NA
WP_009854246.1\|1248066_1249407_-	HAMP domain-containing histidine kinase	Q8QNA2	Ectocarpus_siliculosus_virus	2.2e-08	34.0
WP_009854247.1\|1249396_1250071_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.9e-25	32.3
WP_077496889.1\|1250268_1252812_-	M1 family metallopeptidase	A0A0P0IY26	Acinetobacter_phage	1.5e-66	24.3
WP_009854249.1\|1253034_1253688_-	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_009854250.1\|1253718_1254477_-	phosphate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	5.0e-18	30.5
WP_009854251.1\|1254488_1255292_-	phosphate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.9e-16	28.5

DBSCAN-SWA_4

1399949 : 1409162

Bacillus_phage(37.5%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009854400.1\|1399949_1400441_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	1.3e-46	62.3
WP_172855747.1\|1400453_1401170_-	7-carboxy-7-deazaguanine synthase QueE	E7DN68	Pneumococcus_phage	8.2e-63	47.5
WP_009854402.1\|1401159_1401606_-	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	5.8e-43	58.4
WP_043878574.1\|1401611_1402259_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	1.1e-61	54.7
WP_009854404.1\|1402499_1404269_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.0e-57	30.1
WP_043878575.1\|1404271_1406011_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.0e-38	26.4
WP_009854406.1\|1406088_1407960_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	2.3e-64	32.1
WP_009854407.1\|1407956_1409162_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.2e-42	48.5

DBSCAN-SWA_5

1950257 : 1966154

Streptococcus_phage(76.92%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_074658017.1\|1950257_1951094_-	aldo/keto reductase	A0A1V0SDE7	Indivirus	7.6e-28	32.3
WP_077497505.1\|1951106_1951928_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_077497507.1\|1952032_1952905_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_009854745.1\|1953041_1953398_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	8.0e-35	59.1
WP_061458335.1\|1953410_1953896_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	6.4e-43	53.4
WP_077497509.1\|1953954_1954182_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_074581466.1\|1954282_1955461_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	4.6e-180	81.1
WP_003065991.1\|1955506_1956055_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	8.8e-57	57.9
WP_003065993.1\|1956125_1957217_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	2.7e-174	82.0
WP_013643328.1\|1957352_1957991_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_003066000.1\|1958122_1958464_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_013643329.1\|1958520_1959756_-	ammonium transporter	NA	NA	NA	NA
WP_013643330.1\|1960155_1961022_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.1e-114	71.9
WP_003066006.1\|1961028_1961349_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	1.5e-29	61.3
WP_009854753.1\|1961341_1962142_-	signal peptidase II	NA	NA	NA	NA
WP_077497511.1\|1962138_1963014_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	8.7e-75	50.3
WP_061458340.1\|1963024_1963660_-	dTMP kinase	M1PSC7	Streptococcus_phage	1.2e-70	66.2
WP_012962376.1\|1963846_1964506_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	2.5e-74	65.1
WP_009854757.1\|1964679_1965390_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.0e-17	27.4
WP_003066020.1\|1965389_1966154_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.5e-17	25.2

DBSCAN-SWA_6

2187053 : 2224879

Moraxella_phage(20.0%)

bacteriocin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_074658198.1\|2187053_2188064_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.7e-61	41.0
WP_009854971.1\|2188073_2188514_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_077497715.1\|2188497_2189190_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_009854973.1\|2189367_2189598_+	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_009854974.1\|2189599_2191282_+	ribonuclease J	NA	NA	NA	NA
WP_013643469.1\|2191547_2192177_-	CHAP domain-containing protein	NA	NA	NA	NA
WP_061458093.1\|2192364_2193804_-	glutamate synthase subunit beta	NA	NA	NA	NA
WP_012962507.1\|2193805_2198323_-	glutamate synthase large subunit	NA	NA	NA	NA
WP_013643472.1\|2198500_2199847_-	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_009854980.1\|2199896_2200268_-	MerR family transcriptional regulator	Q9EYF2	Enterobacteria_phage	4.0e-05	35.8
WP_077497718.1\|2200356_2200893_-	aromatic acid exporter family protein	NA	NA	NA	NA
WP_009854982.1\|2201122_2202319_-	phosphoglycerate kinase	NA	NA	NA	NA
WP_004233286.1\|2202506_2203520_-	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_009854983.1\|2203725_2205804_-	elongation factor G	E4ZFJ7	Streptococcus_phage	9.7e-64	29.1
WP_003066535.1\|2206004_2206475_-	30S ribosomal protein S7	NA	NA	NA	NA
WP_009854984.1\|2206495_2206909_-	30S ribosomal protein S12	NA	NA	NA	NA
WP_012962508.1\|2207201_2208014_-	pur operon repressor	NA	NA	NA	NA
WP_061458094.1\|2208180_2209119_-	HD domain-containing protein	NA	NA	NA	NA
WP_012962509.1\|2209108_2210383_-	DNA recombination protein RmuC	NA	NA	NA	NA
WP_013643475.1\|2210384_2211014_-	thiamine diphosphokinase	NA	NA	NA	NA
WP_013643476.1\|2211006_2211669_-	ribulose-phosphate 3-epimerase	NA	NA	NA	NA
WP_077497721.1\|2211675_2212548_-	ribosome small subunit-dependent GTPase A	NA	NA	NA	NA
WP_077497723.1\|2213070_2213271_-\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_077497726.1\|2213403_2214768_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_012962512.1\|2214780_2215509_-	response regulator transcription factor	NA	NA	NA	NA
WP_009854994.1\|2215607_2215901_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_003066564.1\|2216447_2216759_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_013643483.1\|2216770_2216920_-	hypothetical protein	NA	NA	NA	NA
WP_014295304.1\|2217528_2217669_+	hypothetical protein	NA	NA	NA	NA
WP_058621373.1\|2217685_2218996_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_077497729.1\|2219000_2219732_-	response regulator transcription factor	A0A1V0E029	Clostridioides_phage	3.3e-19	25.0
WP_009855002.1\|2219748_2220075_-	LytTR family transcriptional regulator	NA	NA	NA	NA
WP_013643489.1\|2220258_2221551_-	glycosyltransferase family 2 protein	S5WBE2	Pseudomonas_phage	3.0e-07	27.0
WP_013643490.1\|2221552_2221852_-	DUF3884 family protein	NA	NA	NA	NA
WP_013643491.1\|2221877_2222060_-	hypothetical protein	NA	NA	NA	NA
WP_013643492.1\|2222141_2222351_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_077497732.1\|2222340_2223354_-\|bacteriocin	bacteriocin biosynthesis protein	NA	NA	NA	NA
WP_009855009.1\|2224411_2224609_-\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_009855010.1\|2224627_2224879_-\|bacteriocin	bacteriocin class II family protein	NA	NA	NA	NA

DBSCAN-SWA_7

2360231 : 2368099

Streptococcus_phage(83.33%)

integrase

attL 2358105:2358121|attR 2367028:2367044

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2358105:2358121	attL	NA	NA	NA	NA
WP_077497862.1\|2360231_2360504_-	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	5.0e-21	51.2
WP_077497864.1\|2360506_2360848_-	hypothetical protein	NA	NA	NA	NA
WP_077497866.1\|2360844_2361090_-	hypothetical protein	NA	NA	NA	NA
WP_167367617.1\|2361086_2361245_-	hypothetical protein	NA	NA	NA	NA
WP_077497868.1\|2361255_2361573_-	hypothetical protein	NA	NA	NA	NA
WP_077497870.1\|2361584_2361779_-	hypothetical protein	NA	NA	NA	NA
WP_077497872.1\|2361775_2362093_-	hypothetical protein	NA	NA	NA	NA
WP_077497874.1\|2362316_2362955_-	Rha family transcriptional regulator	R9QNB1	Lactococcus_phage	4.9e-27	39.9
WP_003066809.1\|2362970_2363174_-	transcriptional regulator	NA	NA	NA	NA
WP_077497876.1\|2363377_2363896_+	helix-turn-helix transcriptional regulator	A0A1X9I723	Streptococcus_phage	5.8e-18	45.5
WP_077497878.1\|2364175_2364412_+	hypothetical protein	NA	NA	NA	NA
WP_077497880.1\|2364672_2365839_+\|integrase	site-specific integrase	A0A1X9I6A9	Streptococcus_phage	3.7e-145	66.7
WP_009855124.1\|2365964_2366792_+	hypothetical protein	M1PFV6	Streptococcus_phage	8.6e-32	61.7
WP_061458149.1\|2366821_2368099_+	toxic anion resistance protein	M1PLC8	Streptococcus_phage	2.1e-149	70.8
2367028:2367044	attR	NA	NA	NA	NA

DBSCAN-SWA_8

2457153 : 2465292

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077497960.1\|2457153_2457810_-	transglycosylase SLT domain-containing protein	Q4Z8Z7	Staphylococcus_phage	7.6e-23	71.8
WP_077497962.1\|2458015_2458606_-	LysM peptidoglycan-binding domain-containing protein	A0A0A7NNK8	Lactobacillus_phage	9.2e-20	66.3
WP_012962644.1\|2458738_2459536_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_061458219.1\|2459528_2460371_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	6.8e-16	28.5
WP_077497964.1\|2460346_2461189_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	1.8e-16	28.9
WP_009855208.1\|2461185_2461740_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_009855209.1\|2461749_2462694_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_077497966.1\|2462757_2464047_-	insulinase family protein	A0A1E1EST3	Acanthamoeba_castellanii_mimivirus	7.7e-19	30.6
WP_074658529.1\|2464047_2465292_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	7.2e-91	42.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018822

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection