CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019697	Paenalcaligenes hominis strain microbial chromosome, complete genome	2 crisprs	cas3,RT,DEDDh,csa3,c2c9_V-U4,DinG	0	1	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019697_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019697_1

648192-648284

Orphan

Consensus_repeat	Method
TCTCGCCCCCACCTCAGAATAACGCTCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019697_1

>merge|NZ_CP019697|1|648192-648284|CRISPRCasFinder
TCTCGCCCCCACCTCAGAATAACGCTCTCGTTTCAATCTTATGCTCTCGCTTCAATGTTATGCTCTCGCCCCCCACCTCAGAATAACGCTCTC

>NZ_CP019697|1|1|648192-648284|CRISPRCasFinder
TCTCGCCCCCACCTCAGAATAACGCTCTC	GTTTCAATCTTATGCTCTCGCTTCAATGTTATGCT
CTCGCCCCCCACCTCAGAATAACGCTCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019697.1\|WP_159436818.1\|629100_629469_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340391
NZ_CP019697.1\|WP_077733405.1\|656429_658094_+\|acetolactate-synthase	unknown	unknown	gnl\|CDD\|181285
NZ_CP019697.1\|WP_077733389.1\|628480_628921_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NZ_CP019697.1\|WP_077733395.1\|635792_636284_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_077733401.1\|652086_653325_-\|capsular-biosynthesis-protein	unknown	unknown	gnl\|CDD\|319749
NZ_CP019697.1\|WP_077733388.1\|626169_626814_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236776
NZ_CP019697.1\|WP_077733396.1\|636380_638399_+\|ligand-gated-channel-protein	unknown	unknown	gnl\|CDD\|184104
NZ_CP019697.1\|WP_077733394.1\|634898_635453_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273456
NZ_CP019697.1\|WP_077733397.1\|638409_639165_-\|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl\|CDD\|238693
NZ_CP019697.1\|WP_077733398.1\|648825_649668_-\|3-deoxy-8-phosphooctulonate-synthase	unknown	unknown	gnl\|CDD\|237105
NZ_CP019697.1\|WP_077733407.1\|661018_661960_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP019697.1\|WP_077733399.1\|649750_651337_-\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|293739
NZ_CP019697.1\|WP_077733391.1\|629459_630296_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP019697.1\|WP_077733393.1\|630474_631167_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP019697.1\|WP_077733400.1\|651326_652097_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187608
NZ_CP019697.1\|WP_149026089.1\|654787_655729_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_077734950.1\|625767_626157_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240046
NZ_CP019697.1\|WP_077733402.1\|653730_654693_+\|N-carbamoyl-D-amino-acid-hydrolase	unknown	unknown	gnl\|CDD\|143593
NZ_CP019697.1\|WP_077733406.1\|658096_659347_+\|D-amino-acid-dehydrogenase	unknown	unknown	gnl\|CDD\|234819
NZ_CP019697.1\|WP_077733404.1\|655725_656433_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_CP019697.1\|WP_159436818.1\|629100_629469_-\|sensor-histidine-kinase	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	5.01545e-23
NZ_CP019697.1\|WP_077733405.1\|656429_658094_+\|acetolactate-synthase	gnl\|CDD\|181285	PRK08199, PRK08199, thiamine pyrophosphate protein; Validated.	0
NZ_CP019697.1\|WP_077733389.1\|628480_628921_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	6.76974e-06
NZ_CP019697.1\|WP_077733401.1\|652086_653325_-\|capsular-biosynthesis-protein	gnl\|CDD\|319749	cd16441, beta_Kdo_transferase_KpsS, beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase KpsS. KpsS is a beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase. It is part of the ATP-binding cassette transporter dependent capsular polysaccharides (CPSs) synthesis pathway, one of two CPS synthesis pathways present in Escherichia coli. The poly-Kdo linker is thought to be the common feature of CPSs synthesized via this pathway. CPSs are high-molecular-mass cell-surface polysaccharides that are important virulence factors for many pathogenic bacteria.	1.25896e-156
NZ_CP019697.1\|WP_077733388.1\|626169_626814_+\|hypothetical-protein	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	0.000105659
NZ_CP019697.1\|WP_077733396.1\|636380_638399_+\|ligand-gated-channel-protein	gnl\|CDD\|184104	PRK13513, PRK13513, ligand-gated channel protein.	0
NZ_CP019697.1\|WP_077733394.1\|634898_635453_-\|hypothetical-protein	gnl\|CDD\|273456	TIGR01129, Protein_translocase_subunit_SecD, protein-export membrane protein SecD. Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking].	6.35458e-07
NZ_CP019697.1\|WP_077733397.1\|638409_639165_-\|glucosamine-6-phosphate-deaminase	gnl\|CDD\|238693	cd01399, GlcN6P_deaminase, GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.	2.27621e-116
NZ_CP019697.1\|WP_077733399.1\|649750_651337_-\|LTA-synthase-family-protein	gnl\|CDD\|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	1.72779e-46
NZ_CP019697.1\|WP_077733407.1\|661018_661960_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.86645e-123
NZ_CP019697.1\|WP_077733398.1\|648825_649668_-\|3-deoxy-8-phosphooctulonate-synthase	gnl\|CDD\|237105	PRK12457, PRK12457, 3-deoxy-8-phosphooctulonate synthase.	0
NZ_CP019697.1\|WP_077733391.1\|629459_630296_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.11439e-09
NZ_CP019697.1\|WP_077733393.1\|630474_631167_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.92003e-81
NZ_CP019697.1\|WP_077733400.1\|651326_652097_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187608	cd05350, SDR_c6, classical (c) SDR, subgroup 6. These proteins are members of the classical SDR family, with a canonical active site tetrad and a fairly well conserved typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	6.5924e-53
NZ_CP019697.1\|WP_077734950.1\|625767_626157_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240046	cd04690, Nudix_Hydrolase_31, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.83146e-41
NZ_CP019697.1\|WP_077733402.1\|653730_654693_+\|N-carbamoyl-D-amino-acid-hydrolase	gnl\|CDD\|143593	cd07569, DCase, N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases). DCase hydrolyses N-carbamyl-D-amino acids to produce D-amino acids. It is an important biocatalyst in the pharmaceutical industry, producing useful D-amino acids for example in the preparation of beta-lactam antibiotics. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 6. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Agrobacterium radiobacter DCase forms a tetramer (dimer of dimers). Some DCases may form trimers.	3.73412e-146
NZ_CP019697.1\|WP_077733406.1\|658096_659347_+\|D-amino-acid-dehydrogenase	gnl\|CDD\|234819	PRK00711, PRK00711, D-amino acid dehydrogenase.	7.75601e-141
NZ_CP019697.1\|WP_077733404.1\|655725_656433_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.27399e-08

>NZ_CP019697.1|WP_077733397.1|638409_639165_-|glucosamine-6-phosphate-deaminase
MFYRFTNPQAIADYVTAEWVELIQRNPKAVLGLATGSTMEPVYETFVRQVQQQQVALDQLSTFNLDEYIGLGADHPQSYHYYMQQQLFGLVPFNPQRVHLPNGLCDSLEQQCMDYHNLIQQLGGIDWQLLGIGTNGHIGFNEPGTSFSSQVHVVDLSPQTRRDNSRFFTDTSQMPTRAITLGLGDIIEAKQILLLATGANKAQIMADLYHSEVDEALPASILKTHPNVRILVDEAAAQLLPPAAFQTALTA
>NZ_CP019697.1|WP_077733396.1|636380_638399_+|ligand-gated-channel-protein
MNTSLSHSGWRLSTACLALSTVIPIAYAQPKPDNAVSQLQHVVVTASGFEQLVEDAPASISVIPREELQKKAYRDVTDALRDVPGVVITGGGSSSDISIRGMAAGYTLILIDGKRVNSRETRPNSDNAGIEQGWMPPIEAIDRIEVVRGPMSSLYGSEAMGGVINIITRKVADTWTGSLRTEATLQQHSDSGNSYQGNFYVAGPIKENRLGVQISGQKTRRNEDDFLQGFSKQDTQSGTIKFTLTPSQNHDLIAEVGRTEQKRISTPGHTMALETCGRNGCTPNEASESHYTRDSYALTHKGRYGNLQSESFIQQDRNKNPGRNMFIKNTELNSQWNTLLGDHHVTFGAQYLSEKLEDHGNQYKPEVSDLSRYQWAAYAEDEWEIHPSFSLTTGLRLTHDENYGNHWTPRLYGVWHANDELSVKAGVSTGFKAPSLRAAVADWGQITGGGGVPAVIVGNPNLKPEKSISQEIGFIWDNRENLNLGLTFFNTQFKDKISEVRRCTDPDGLATCHVVPGDQGYKFISDRVNVDKAVMRGIEAVASWSITDDLQLSSNYTFTHSKQKSGDFAGRPLNKMPKHMFNSTLDWDYSPELNVWTRVNFRGKSSDYLSRTAMREGTPSFTFVDMGLGYKISKHTNVGVGIYNVFDKRVTTETHEAVYDGRRYWAQLTMGF
>NZ_CP019697.1|WP_077733395.1|635792_636284_+|hypothetical-protein
MRPTTLAELDQARLRCQKLVSRRALVSAAAAVVPIPGVDVSTDVAILLQLIPAINEEFGLSPSQINALSPELQKIVIVGGANFGVGLLGKIITPQLVIQVLQRIGVKKLAGKYATKYIPVVGSVIASTVSYAVLRKVGNQHINECYAMAKQLIEVDDTALTTT
>NZ_CP019697.1|WP_077733394.1|634898_635453_-|hypothetical-protein
MPKLKLISRLLAPMALLALAACQTPPTTPGTSAPADGTAPATTPASPSDATQAPEAQMAAPLLVFLADTQPHADWAEVQIDASNVLYLEPEAFLTRNDLDTVEAGTSETGEGLLALTLNSAAAERLTRLTQQNPNKRLALVVDGTLLAIPGYSEPITEGRLIFMVGSRENAMMAARIIAGEDAQ
>NZ_CP019697.1|WP_077733393.1|630474_631167_-|response-regulator-transcription-factor
MIRCLLVEDDTVNAKFVQHALEKQGYHVTWVADGATALEHLLHHDWSLVILDRMLPDEFDGLSLLTTIRSLHKSYPVLVLSALSGLDDRVRGLKAGGDDYLVKPFALPELLARVEVLIRRYVAMQKPEDNTELVVGDLRIDLLSAKVERAGKTILLQPKELQLLVYLIKHKNQIVTRSMLLEQVWGYRFEPNTNLTDVQISRLRNKIDKPFEHAFIHTVRGVGYRFVHEA
>NZ_CP019697.1|WP_077733391.1|629459_630296_-|HAMP-domain-containing-histidine-kinase
MAKRVEALYATQGRDAVIDYIRYEIQGQSPDLWFFMDLNDRKVVGNMDYYPMAFEGSDYIADLTIHKEGRSLEAKLQRVNLGGDIVLVGKDLRDIYAFRGLMFRASLITIVTGLFFVVLSTYWFRAEIASNVSVIRRTAAHIRAGQFKRRIPVENTDDELNLLIKELNLMLDHLEKSLTGVRYLSETITHNLRTPIMRITSHLYPLAYDTVPPEAAQEKAQHVLEELEALTTLFDKLLQISELESGCIDKANRPSILVHCSRTWWHYMVPMPRKSPCS
>NZ_CP019697.1|WP_159436818.1|629100_629469_-|sensor-histidine-kinase
MQLTAQLSPDCQVHGDADLLASALSNLLENACKYGRTFIQLRLYKKGYLTVFEIEDDGIGVSDKSLAKLGTHFYRDQVAEHIPGTGLGLTSVLSIVNFHQGQCEFYRSTLGGLGIRITLDSV
>NZ_CP019697.1|WP_077733389.1|628480_628921_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MVRWVAGTHRYGYRFRQLKLPNWLVSTNGAGLFSLDVGGILMVLGLLVLISPELDRAGADDGLDKLSLKAQLTTWGLVIGSVALFAILGKYGGLVPATFFLTFVAAFADHKNTFKVALAVGVALTAFTVAVFHYGLQMQLPLFTWG
>NZ_CP019697.1|WP_077733388.1|626169_626814_+|hypothetical-protein
MNTHTTQTTHCFTLQQLRAATQAGGVAGVSLKAQGSGFFIQIQLRTGQNAVLVTARSRSPRMFKNPAQAFGVLKRVGIVTGSFDVTHYSPEQQQTDNDTKKKEKNTVSAKAPRAPKKPVPSAPEPAPAVVASAAPVVAPSAPAVQATPTVELTPVAAAVTTPATTPPLPLQQWTLKKPHRPRPSHRPLHWVYSSHLSSHTCLMAGRCSLYLLTR
>NZ_CP019697.1|WP_077734950.1|625767_626157_+|NUDIX-domain-containing-protein
MPEIYIAAAIILDPSGHMLLVRKKNTARFMQAGGKIEKDETPLAALLREMREELQIEPDANQIFYHGQFLAAAANKPNHTVRAHIYQLTWHNPIHIAAEIEEAVWITPTSASTLPLAPLTEHIILPLLI
>NZ_CP019697.1|WP_077733398.1|648825_649668_-|3-deoxy-8-phosphooctulonate-synthase
MIVQIQNLHVANHLPFVLFGGLNVLEDTEQTLEVCQHFVEVTKKLNIPLVFKASFDKANRSSIHSFRGVGLEKGMQIFDAVRQQFGVPIITDVHEPYQAAQVAEHVDVLQLPAFLARQTDLVVALAKTQKVINIKKPQFLSPSQTAHIVEKFKEAGNDQLILCDRGTCFGYDNLVVDMLGFSVMKQVTHNHPVIFDVTHALQQRNPNDPASGGRRQQIVELAHAGMATKLAGLFLEAHPNPDQAKCDGPSALPLSLLEPFLTQVKAIDDVVKNFEALAIS
>NZ_CP019697.1|WP_077733399.1|649750_651337_-|LTA-synthase-family-protein
MSIDFALIAVAMVGYKVSLVLDYAAKPRPRVMRHLRHFCVHTGLWLLGFALEMLLFQRPWFALFNLLGLQLLLIIISNMKQHFLREPFFYTDTEYFWDAIKHPRLYLPFFGIGNTVLGFAIYLGAAALAFYFEPAYSQWPIAVLGFAVAGAVALLLGDSLAQAQPSWQPSADIQQMGFTPALWRYAQAERQALALDEHAPFAQTWQAPALLPHLVVVQSESFFDPRRYYADYVQPHVLTQFDQMAATGQRGVLQVPSWGANTVRTEYAVLSGLEPSLLGVHQFNPYRRLAKHCVPSLAHYLRSIGYKTICVHPYAASFYRRNTAMPLLGFDEFIDIRAFTKDDYFGAYVSDAALARTLTGVLQAQTDQPVFVHVITMENHGPLHWETVSATETHALMQQPVPSGAEDLVPYVRHIQHTDQLLQHVQQTLLTLTRPTGLCLFGDHVPIMSGVYKQLGEPDGSTDYLLWRSDAAKSPNAPATPTAPAANALTAAQLGPAWLAFMGFNQVNASPAPQPLNPPDAAPNQPHE
>NZ_CP019697.1|WP_077733400.1|651326_652097_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSLDPQTILITGATGGIGRALAIAYAAPGVQLVLQGRNPDLLAGVQQACQQLGAQVETVRFDLSDTEGWRAWLLAFCAQCPVDLLFANAGVNINHGEDNAGEQWDEIRQLLRINVDAVFATVHGVLPSMRARAQGQIVLMSSLAAYRGLPVTPSYSASKAAVKVYGEGLRDWLAPQGVRLSVVMPGYVSSKMCEEMPGPKPFLWAAPKAAAYIQKRLRRNPPRISFPFPLNFGTWGLSVLHPSVSAWILRRLDYEH
>NZ_CP019697.1|WP_077733401.1|652086_653325_-|capsular-biosynthesis-protein
MNHQFLFLQGVNSPFFADLAEALKKQGHGAVRLNFTVGDRVFWRRNGNAHDCVLPADQMTAFMAEFYRTQAVTDVVLFGDERPVHTAAIQIAKQLGVRVHVFEEGYFRPYWFTLERGGVNANSALPKDPLWYTEWGPLVPNYRNGLSFRSSFYMRAWFDVAYHFCSLANRWHFPNYHYHAPHTAWQEYWPYLAKQLKQNVLRRQAQDNKTIGRFLAQDKAFYLLPLQLDSDAQIRCHSPFDNMYQVMDTVLASFAQHAPADAVLVIKNHPLDMGLVNHEKNASALAQHYDLADRVVFLQTGAMPTLLGQATGVVTVNSTVGASALYHALPTKVLGEAIYDIEGLSYAGSLDAFWQDLHRPNMNLFHHFRNVVIHATQLNGGFYTSAGIRMAVQQAIPALLAPQSFIEMNYVP
>NZ_CP019697.1|WP_077733402.1|653730_654693_+|N-carbamoyl-D-amino-acid-hydrolase
MTPVITIAGAQMGATQKNDTRESVAQRIQHLIEQAAKRGAQLIVFPELCLTPFFPRWYYETLEEADQWFEDQWPPRGLENALQKAKDLNIMVQISYAEKTLDNHRYNTARLISSAGEHLMKYRKIHLPGHADYIPERPLQHLEKRYFEVGNLGFPVERFYLENVGEFNLGMLLCNDRRWPEAWRVLGLQEVDIVLIGYNTPVANLDVTHHQPPHLKVMQSNLSVQAGCYQNNCFGVSVAKAGVEDGHAMFGSSIIVNPFGEIIARSSTWHDELIIADCDLSLCQVNRASTFNFEAHRRPEHYQRIVEQTGSIRPKKVVQA
>NZ_CP019697.1|WP_149026089.1|654787_655729_+|hypothetical-protein
MTIGIAAVGPHAVSVVIDALRATETLGAGAIGGFAVLNVMDHNGATHSCETQEGGSTQLVIPDSWLGYERAALISSGPHRPPPLSQFLASQNHVGLVTGHRLPNREVNGAPLNKTALQQLALGQTAQEAVTIALDADPECDAGLIALSATGALALANSARVQRRLDVYTAMHQHGDSSIALLMNSIAFPAIVMRTDPATLVAQIASQRFRAQTAPATFSLVSIDAHCQLAQADHDLIVVHASARRVLRIVSADQSLSNARGRRTIIQNGTPVVDTEGAFLGVSYNDIIANVTLCALDPQTHFSSLGLVIGPQP
>NZ_CP019697.1|WP_077733404.1|655725_656433_+|TetR/AcrR-family-transcriptional-regulator
MTLSRREKTEQRIMQALEDQIRATGMVGVGINAIAERAGVSKELIYRYFDGLPGLMMQWMKNQDFWTSNSSTLRDPSAETNTPKELILKMLRAQISALQNNDALKEIRRWELIERNEVSGQLAERREMAARPFIDELDALNDEMDVPAMVSVMLAGVLYLSLRAKTESQFLGVPLRTSEGWKRIDNALIQLTQSLPAEFQNTTLKELRAHHPQTETNVKNPSGSDSLPKHNEASE
>NZ_CP019697.1|WP_077733405.1|656429_658094_+|acetolactate-synthase
MTIRAADLLVQCLVAHDIDHVYCVPGESYLSVLDSLVDEQSIQVITCRHEGGAGFMALGDMRLRTTPAVLMVSRGPGCMNAAIAIHSAQQDAAPLVVFIGQAERENLRRDAFQGMNYERVFVDVAKWVVEVNDPNQLADTVCMAFKIAQAGTPGPVVISLPEDMLEEHCNSAAFYPRQAVKSTLTLADTEAILQSLSTAKHPLVIAGGLLKSQDGKAALLQFAEQFSLPVATTVRHADLFPNDHPLFAGHLTVGLPADLATIYEKIDLIIAVGTRLGDVTTQSFAFPAAPKAAQKLIHIWPDADVVGRYRQTDIGIAADPTSVLRSLCQNAAPTTAWNEWTAQLHTTVSELRHWQTRPDAEDGVIFGNIVAQADQMLPEDAILCLDAGNFGGWVQRLFRFSPTRKLIGPSSGAMGYGVPAAVACALLEPEKKVVCFVGDGGFLMTGSELATAQQFGAAPIIIISDNSAYGTIRMHQELHFPKRKSATTLLNPDFVAMATAYGANAFLVEQSDQFASALEQALHSNQLCVIVVRTSLEHISVSATISQLRHVDSE
>NZ_CP019697.1|WP_077733406.1|658096_659347_+|D-amino-acid-dehydrogenase
MTHFLVIGAGIVGLATAYELRQKGFEVTVVEAQSQAGQETSKANGAQLSYSFVSPLASPAVVKSLHKLLLDRHGALRIRPHADGQQLHWLWHFLKACSASRSRQTSEDLLYLGALSKDVLTALLQQHPIAFSHNQNGKLLVFESSAALADARIQAEFLRSHGVTQTELTVEQTCALEPSLHPIKHRIHGAIFTPSEQAGDCEALCLGLSEVLAKQGVNFRYNTPLTRLETTPSRGIQAYTHQEAIPADAIVLANGIGAQALAKNVGLNLGIYPLRGYSLTYAVNDTSGAPQTSVSDIRNKVVYARIGDKLRVAGMIDIGINDPQTIEDRTHTLKAQVQEFLPALKPLHSPVFWSGQRPARPDSKPVIGRTSIPNLFVNAGHGALGFTLAFGSARLLADAVAQSTQPHSQLAARFEL
>NZ_CP019697.1|WP_077733407.1|661018_661960_+|ABC-transporter-permease
MLAYIARRIVTTIPVVVMVAIVIFALLRLTPGDPAAIIAGDDASPAQLEAIRIQMGLNLPIYEQFFQWTSDLLKGNLGTSLLSNTPVTALIADRMGPTIALAIATLSFTLLIAIPIGVIAAWRHGKITDRFVMILSVLGFSIPTFVVGYLLIYIFSMKLGWFPVQGYRDLSSGFYEFARRLTLPTIALSAVYTALIARITRSSVIEVMNEDFVRTARAKGVKESTVLLRHALRNAAVPIVTVIGIGAASLIGGVVVTESVFNIPGLGRLVVEAVLARDYPIIQGVILLFSLTYIVINLIVDVLYTVFDPRITY

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Crispr_ID: NZ_CP019697_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019697_2

732384-732534

Orphan

I-B,III-A,III-B

Consensus_repeat	Method
AGAAACACCCCCACGTGCGTGGGGAAGAC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP019697_2

>merge|NZ_CP019697|2|732384-732534|PILER-CR
AGAAACACCCCCACGTGTGTGGGGAAGACCCTTATCCCCACGCCAAGCTCGCCACTTCCTTGGAAACACCCCCACGTGCGTGGGGAAGACGCGCCAACGATTTACCACACCCGGGCTTAGCCAGAAACACCCCCACGTGCGTGGGGAAGAC

>NZ_CP019697|2|1|732384-732534|PILER-CR
AGAAACACCCCCACGTGTGTGGGGAAGAC	CCTTATCCCCACGCCAAGCTCGCCACTTCCTT
GGAAACACCCCCACGTGCGTGGGGAAGAC	GCGCCAACGATTTACCACACCCGGGCTTAGCC
AGAAACACCCCCACGTGCGTGGGGAAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019697.1\|WP_149026091.1\|720505_720772_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_077733461.1\|735479_736676_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP019697.1\|WP_077733452.1\|727532_728867_+\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148
NZ_CP019697.1\|WP_077733457.1\|733591_733801_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP019697.1\|WP_077733455.1\|731113_732208_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP019697.1\|WP_077733454.1\|730208_730496_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_077733449.1\|719353_719881_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_077733453.1\|729772_729991_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_077733450.1\|720155_720506_+\|META-domain-containing-protein	unknown	unknown	gnl\|CDD\|377111
NZ_CP019697.1\|WP_077733460.1\|735175_735412_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_159436824.1\|720761_720965_+\|DUF4377-domain-containing-protein	unknown	unknown	gnl\|CDD\|379548
NZ_CP019697.1\|WP_077733463.1\|738881_739850_-\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270320
NZ_CP019697.1\|WP_173834764.1\|741077_741626_-\|hydantoinase-B/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|376810
NZ_CP019697.1\|WP_077733459.1\|734301_735063_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP019697.1\|WP_077733462.1\|738270_738822_-\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP019697.1\|WP_173834763.1\|739944_741078_-\|hydantoinase-B/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223224
NZ_CP019697.1\|WP_077733456.1\|732773_733271_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP019697.1\|WP_077733458.1\|733937_734237_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019697.1\|WP_173834772.1\|720976_723022_-\|capsular-polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226093
NZ_CP019697.1\|WP_149026092.1\|723011_723200_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019697.1\|WP_077733461.1\|735479_736676_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.74037e-22
NZ_CP019697.1\|WP_077733452.1\|727532_728867_+\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	2.40299e-126
NZ_CP019697.1\|WP_077733457.1\|733591_733801_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	2.99357e-30
NZ_CP019697.1\|WP_077733455.1\|731113_732208_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	2.6204e-26
NZ_CP019697.1\|WP_077733463.1\|738881_739850_-\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.83468e-112
NZ_CP019697.1\|WP_077733459.1\|734301_735063_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.41029e-08
NZ_CP019697.1\|WP_077733450.1\|720155_720506_+\|META-domain-containing-protein	gnl\|CDD\|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	7.09807e-09
NZ_CP019697.1\|WP_159436824.1\|720761_720965_+\|DUF4377-domain-containing-protein	gnl\|CDD\|379548	pfam14302, DUF4377, Domain of unknown function (DUF4377). This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	5.62375e-09
NZ_CP019697.1\|WP_173834764.1\|741077_741626_-\|hydantoinase-B/oxoprolinase-family-protein	gnl\|CDD\|376810	pfam02538, Hydantoinase_B, Hydantoinase B/oxoprolinase. This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.	9.6501e-83
NZ_CP019697.1\|WP_077733462.1\|738270_738822_-\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	6.43281e-10
NZ_CP019697.1\|WP_077733456.1\|732773_733271_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	5.7031e-41
NZ_CP019697.1\|WP_173834772.1\|720976_723022_-\|capsular-polysaccharide-biosynthesis-protein	gnl\|CDD\|226093	COG3563, KpsC, Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane].	0
NZ_CP019697.1\|WP_173834763.1\|739944_741078_-\|hydantoinase-B/oxoprolinase-family-protein	gnl\|CDD\|223224	COG0146, HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.27829e-170

>NZ_CP019697.1|WP_077733455.1|731113_732208_+|acyltransferase
MIKSVHYLRGLAALLVVFFHFRYYLNDYYAHSRLGDLLFANGAFGVDLFFIISGFIICYATQRPEPKPLVSYALKRIFRIYPLLIVSLVVFYLLFGDNNTSVLRSLLPLHADYSQSGPFFGYNMLSPVWTLTYEIFFYGLFFIGLMLSQRYRKVLVLGLIMAVFVASQLAVNQELELSAYTQFDYTSNALLQPLIALVSSPMLLEFGYGIILYMVFQSLPAWSAPTQRRLLPWVVLLAVVAAVALYLPSFYGHGPLKWGLAAWVLLFAALLYERIQGIPTIPVLHFLGDISFSLYLTHIIMIKVIRKYGWDLGLEGGAAFLWAVIASLVVATLLFYVVEKNAIVLCRKLLQRVNTPREREMAYV
>NZ_CP019697.1|WP_077733454.1|730208_730496_+|hypothetical-protein
MNDATFTFRVDEGLKAEFANAAKAHDRTGAQLLRDFMRSYVAQQKETQQYDAWLAKKVEQSRASAEAGNLIPASDVEARFAARRAATRARMAASE
>NZ_CP019697.1|WP_077733453.1|729772_729991_-|hypothetical-protein
MSGSVESVVSASIALQGHALAQEKDNLLLKKVLANQEQTIMSLLDAAAVTPKTGPQPLAQSGAVGTQVHVTA
>NZ_CP019697.1|WP_077733452.1|727532_728867_+|magnesium-transporter
MFASIKKLQSFDHVADAVSYLNQLKTAEALKLATQLDAETLINLLESPELKHSHEITLLLISSGRADVLDCLAEDRMADLMTGFNPHVQQQGLALLSPSSKASILRLMSYPQGTAGSIMTTEFIQAPMAWTVAQTLQHIREVESTRETVYAIYVVDIYNRLQFVLPLRQLVIADAEQPLTELWTGQTPVMVDPYTDREEVARLIRLYNFLALPVVDDDEHVVGIVTVDDVIDALMDEAAEDLGRFGGGEHIGKPYLDVSFGTMVRKRGGWLAILFLGEMLTASAMQFYEMELEKAVVLAMFIPLIMSSGGNSGSQATSLLIRGLALGEVKLKDWWRVILREFPTGFVLGAGLGAIGFLRIVAWQYLGIYDYGEHYALLGFTIWASLIGIVCFGSSLGSMLPFLLQRFNFDPASASAPLVATLVDVLGLVIYFSVAALILTGTIL
>NZ_CP019697.1|WP_149026092.1|723011_723200_+|hypothetical-protein
MYFTRGARYGGFWLTAILPWFGVSWFVLSCTPIRLAVLARFTRSALNRSSVCMTAHAKTGRF
>NZ_CP019697.1|WP_173834772.1|720976_723022_-|capsular-polysaccharide-biosynthesis-protein
MKYIYSSKTLRKLPFLTEFLNDLDHLGPTIVLGWGQRPTTVKARAYARKHGLPYVALEDGFLRSVDLGVNGAAPLSMVVDEIGIYYDARHPSKLEQLIAQTRAEDHELKRQAQTAQAYLVQHQLSKYNHAPVMALPPLPGDLTHRVLVVDQTRGDMSVVNGGGEDGVVAMLDAALHDNPTAQIMVKTHPDVLTGKKQGYLTDHPLLTHPRVLIWAKDCAPLPLLSQVDQVYVYTSQMGFEAVMLNKPVHCFGLPWYAGWGVTTDYHPQRQQLQQRRATPKAVWQLFAAAYLHYVRYLHPDLGRAGTLMDVMSWLVRNRDAAQQLRGTLYCVGMSFWKQATVRPFLRAHTNRLVFVPSLAKLNRMTLAADAKLVTWGSRDLTQAQQLAQQKNIPLWRMEDGFVRSVGLGSDLFRPLSLVVDRSGMYYDPHSQSDLEQMLLQGQWTAAQEQHALDYITAFTQKGLSKYNLGGQSIHVTNQSKRIVLIPGQVEDDASVRYGSPVITTNAQLIKAVRKQCPDAYLIYKPHPDVVVGNRKGQVPDQVLAQYVDHVVVNANIVECLRLADEVHTMTSLTGFEALLHGKEVHCYGGPFYAGWGLTQDHYPLPHRQRQVTLAQLVYTTIFQYPRYSMPFKIGTSGFAAPESVLAWLSQQADQQKNSAAAPGWFNNKKRKATALWQLLRS
>NZ_CP019697.1|WP_159436824.1|720761_720965_+|DUF4377-domain-containing-protein
MHYDQNGVSTGTGDWILFQPNAIEGYEHVNGVGTIVRTKRYAIPNAPAGSATDAYVLDMVVQSNTGL
>NZ_CP019697.1|WP_149026091.1|720505_720772_+|hypothetical-protein
MQYEQEVARLLPTASTWSLATTDQTAQDAPAPVLSLHFDNGQIWSFAGKQTNEAKYGGQAEMVFLEVSPTPRCAPKRQYVFKSTPGAL
>NZ_CP019697.1|WP_077733450.1|720155_720506_+|META-domain-containing-protein
MKRKLTFLTAAFATAGLAACSAPSTTVMTDSGKKVTLSPAETIQAYHWDLVNVVEPDGASKNVGKTLDHPLTLTFLDDVVALQNLCNNLNASYNLQENSIAFSQVVGTMKMCNDPS
>NZ_CP019697.1|WP_077733449.1|719353_719881_-|hypothetical-protein
MSTNPISGEQSNTKFLAVFDTQAELEQCKTALEQTGYDPNQITVVAPHDRRYSRKIEPESKGIFQTAIKAHTLFGILGFLVGLGLWAGLYWSGIPMIVSSPVVSVIPFLFVFTSGGLLLGGFLTLRPDHLMVIQGVKEAKRQGRWSLIVHSRNATQTVQVEEWFKTANISAVRSL
>NZ_CP019697.1|WP_077733456.1|732773_733271_-|MgtC/SapB-family-protein
MSILADIWQTIVHEFSDIADMKEATVIGLRLSVAALLGAAIGYERERRGKDAGLRTHMLVALGAAIFILVPVTGDMTSADASRVMQGIISGIGFLGAGAILKQEKEHIVAGLTTAASIWVAAAVGIAAGYGREATAVASTVVALFVLAVLGRLETSQAANSEKNP
>NZ_CP019697.1|WP_077733457.1|733591_733801_-|cold-shock-protein
MKKTFGIVKWFNNEKGFGFIMPEDGGKDLFAHHSEIQGAGYKSLEENQRVSFVVGSGQKGPCATQIEVA
>NZ_CP019697.1|WP_077733458.1|733937_734237_-|hypothetical-protein
MNITHLEHLLIGLVIQGLFVLGFNALKRPDGVWYGAFFVTALFLGREHAQREYKIGDPSQLVGYEALDLWRWSLDAQLDFFVPTVAVFLVAGLVAWFKR
>NZ_CP019697.1|WP_077733459.1|734301_735063_-|class-I-SAM-dependent-methyltransferase
MFSDLTDEMGDLDGYSIEPKFFLDVPFVPTDDALIAAMLRLADIKKTDTLYDLGAGDGRIVITAAQKFGIRAIGVELDPLRVSEAMEDAAHARVEHLVDFLEEDLFKADFSSASVVTMYLMDSVNVMLRPRLLNELRPGTRIVSHAFDMGDWRADVEENLGGITLYKWVIPAKVEGTWQWEGVDGCVYHLELQQKYQDVTGEVWVDDEPAQLVECTLNGARLDLRVQTHDNDQPQYMVLSFEADAENPELEWF
>NZ_CP019697.1|WP_077733460.1|735175_735412_-|hypothetical-protein
MKASTVWVGVSLSLFLLSGCGSSPKSTTQTQRYQCKLDPQSCMYEGAYEHDEEAYAEQRAKELNKASARKIKRRGGWW
>NZ_CP019697.1|WP_077733461.1|735479_736676_-|MFS-transporter
MGSSQAKAGLSPFQIALFLVIVGISAALHVWKLAPALPALQNELQLSLVESGFLLSSVQIGGMSLGLMIGLFAERIGLKRCIVIGLSILVLGSVASTLTHHKTVVLLCRALEGCGFLMVVLPVPALIKRLVAPQQLSQVMGLWGCYMPMGAVITLWAGSWFLTVGSWRLLWLILGGLSLLFMVLAWRILPRDARTVSTQRTQDHALLHMVSLTLRTKKVWLVAVVFCVYAAQWAGVIGFLPTFYIAGNISGALAGFLTGMVAGANILGNLGAGRLIQKKIAPHHLLFFGFTTMMVCAVLAFGLNIGLLWQFLAILTFSAVGGLIPATCFYLAVNYAPSPQTTSSTVGWVQQLSSLGQFFGPPAVALAVNALGGWHWAWTATVSFAVVGLVLAWLLSRR
>NZ_CP019697.1|WP_077733462.1|738270_738822_-|TRAP-transporter-small-permease
MRKSLDRLYGLSGAVAAFSLFMIMLIVFGQVMLNTIDFIALHLVGKSYGFLIPSYAQFSGYALGFTTFLSLGLGFRKAAHIRVTLIETALKPTARRYTLTLVALIGTLLGALISYSLADLAWQSWMWGDTATGLVRLPLWIPQSVLALGAIVFFISALDTLVDMLRYKQSTALRAIDPVEEVM
>NZ_CP019697.1|WP_077733463.1|738881_739850_-|TRAP-transporter-substrate-binding-protein
MKLHQYMTAAAVVACSMTAAHAESWRMATAYPETNFHTVNIQEFVNEIKDATDGKLDITVHANGSLIRPGELKNAVRSRQVETGEFIISGLANENPIFAVDSVPFLAVSYEDSEKLYEITKPYLEDLLGRQNMQLLYSVAWPPQGMYTDREINTIDDLKGLRMRAYSPQTERLAQLSGAVPTQIEAADLAQAFSTGRVNAMITSASTGVNSSAWDFLSHYYDVAAFLPKNVVVVNKHSFDALDDETKKVVLDAAAKAEKRGWERSREERVKQTKLLEDNGIKVSSGSDELRAALLEVGQKMAAEWSKEAGKEGETIINAFQQ
>NZ_CP019697.1|WP_173834763.1|739944_741078_-|hydantoinase-B/oxoprolinase-family-protein
MDEGVLIDNFKLVEKGEMRADALSELLQSGPYPARNISQNLADLRAQIAANEKGAQELHRMVQTFGLDVVQAYMQHVQNNAEESVRRVIDVLQDGHFRYELDNGAHIEVAVRVNKAQRGATVDFTGTSAQLESNFNAPKAVCLAAVLYVFRTLVNDEIPMNQGCLKPIEVIIPEGCMLNPSYPAATVAGNVETSQCITDALYGALGVMAASQGTMNNFTFGDEQYQYYETIAGGSGAGMILHTDGTHEVFDGTDVVQTHMTNSRLTDPEILEWRYPVVLEEFSIRPDSGGLGQGVGGNGGTRRIRFLTPMTASILANRRRIAPFGAAGGQPAEVGSNYVERADGSTESLGATASVQMKAGDVFVIHTPGGGGFGQSN
>NZ_CP019697.1|WP_173834764.1|741077_741626_-|hydantoinase-B/oxoprolinase-family-protein
MFDQNGTTIIEPEWQLDVLSAGEMLLSRVKPKAKQVAIGTDVDPVMLEIFNNLFMSIAEQMGATLANTAFSVNIKERLDFSCALFDAEGNLIANAPHMPVHLGSMGESIKAVIQKNAGQMRPGDTYVLNDPYNGGTHLPDITVVTPIFNDAQTEILFFVASRGHHADVGGLTPGSMPLIAKR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019697_2	2.1\|732413\|32\|NZ_CP019697\|PILER-CR	732413-732444	32	NZ_CP023068	Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence	1454531-1454562	9	0.719

1. spacer 2.1|732413|32|NZ_CP019697|PILER-CR matches to NZ_CP023068 (Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence) position: , mismatch: 9, identity: 0.719

ccttatccccacgccaagctcgccacttcctt	CRISPR spacer
aattgtcgccacgccaagctcgccaagaccgc	Protospacer
  **.** *****************   ** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

247880 : 270125

Pseudomonas_phage(40.0%)

capsid,terminase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077733067.1\|247880_248957_+	DUF262 domain-containing protein	A0A0R6PKN1	Moraxella_phage	1.3e-56	38.5
WP_077733068.1\|248953_249673_+	hypothetical protein	A0A0R6PER3	Moraxella_phage	1.0e-12	28.0
WP_077734934.1\|249669_250698_-	DNA (cytosine-5-)-methyltransferase	A0A0R6PG08	Moraxella_phage	9.5e-105	54.3
WP_077733069.1\|250793_251492_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_159436805.1\|251745_251940_-	hypothetical protein	NA	NA	NA	NA
WP_077733071.1\|251994_252573_+	hypothetical protein	J7I4J9	Pseudomonas_phage	3.2e-25	43.8
WP_077733072.1\|252565_253006_+	recombination protein NinB	A0A1B0VMG4	Pseudomonas_phage	4.9e-10	34.9
WP_077734935.1\|253122_253485_+	recombinase	A0A222YXV2	Escherichia_phage	2.3e-13	46.8
WP_077733073.1\|253481_254312_+	conserved phage C-terminal domain-containing protein	A0A2H4JAR8	uncultured_Caudovirales_phage	2.0e-12	33.6
WP_077733074.1\|254292_255024_+	ATP-binding protein	A0A067ZJ24	Vibrio_phage	1.6e-50	47.6
WP_077733076.1\|255369_255729_+	hypothetical protein	NA	NA	NA	NA
WP_159436806.1\|256062_256230_+	hypothetical protein	NA	NA	NA	NA
WP_077733078.1\|256216_256627_+	hypothetical protein	NA	NA	NA	NA
WP_077733079.1\|256711_256918_+	hypothetical protein	NA	NA	NA	NA
WP_077733080.1\|256889_257180_-	hypothetical protein	NA	NA	NA	NA
WP_077733081.1\|257324_257552_+	hypothetical protein	NA	NA	NA	NA
WP_077734936.1\|257602_258121_+	hypothetical protein	A0A2H4J2I6	uncultured_Caudovirales_phage	6.8e-51	62.4
WP_077733082.1\|258123_259611_+\|terminase	terminase	A0A0H5ARR1	Pseudomonas_phage	6.3e-243	81.1
WP_077733083.1\|259611_260979_+	DUF4055 domain-containing protein	A0A2H4J0H4	uncultured_Caudovirales_phage	6.1e-176	69.5
WP_077733084.1\|260962_262159_+\|capsid	minor capsid protein	A0A0P0IR98	Acinetobacter_phage	6.3e-68	39.0
WP_159436807.1\|262151_262307_+	hypothetical protein	NA	NA	NA	NA
WP_077733085.1\|262411_263179_+	hypothetical protein	A0A2H4J0I7	uncultured_Caudovirales_phage	1.4e-76	63.2
WP_149026180.1\|264473_264575_+	hypothetical protein	NA	NA	NA	NA
WP_077733087.1\|264575_264950_+	hypothetical protein	A0A0S2SYB7	Pseudomonas_phage	2.4e-29	54.6
WP_077733088.1\|264951_265308_+	hypothetical protein	A0A0S2SYG4	Pseudomonas_phage	7.5e-25	52.1
WP_077733089.1\|265309_265693_+	hypothetical protein	A0A059VF88	Pseudomonas_phage	1.1e-21	44.8
WP_077733090.1\|265689_266109_+	hypothetical protein	A0A059VK45	Pseudomonas_phage	3.8e-44	59.7
WP_077733091.1\|266281_267016_+	KilA-N domain-containing protein	K7PH51	Enterobacterial_phage	3.4e-64	49.2
WP_077733092.1\|267015_267411_+	hypothetical protein	NA	NA	NA	NA
WP_077733093.1\|267456_268383_+	hypothetical protein	A0A059VG08	Pseudomonas_phage	1.7e-116	68.3
WP_077733094.1\|268447_268921_+	hypothetical protein	NA	NA	NA	NA
WP_077733095.1\|269234_270125_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	2.5e-37	44.9

DBSCAN-SWA_2

432526 : 439504

uncultured_Mediterranean_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077733216.1\|432526_433885_-	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.8e-27	25.8
WP_077733217.1\|433906_434767_-	peptidoglycan DD-metalloendopeptidase family protein	A0A2K9V574	Lactobacillus_phage	9.4e-05	47.4
WP_149026073.1\|434782_435577_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	7.2e-36	45.4
WP_077733219.1\|435605_436349_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.1e-70	51.0
WP_077733220.1\|437083_438118_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	5.3e-95	51.9
WP_077733221.1\|438211_439504_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	2.7e-64	36.8

DBSCAN-SWA_3

451544 : 512883

Pseudomonas_phage(48.48%)

head,integrase,terminase,tRNA,tail

attL 459593:459608|attR 502731:502746

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077734942.1\|451544_452357_-\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_149026075.1\|452367_452565_-	hypothetical protein	NA	NA	NA	NA
WP_077733229.1\|452522_453740_-	hypothetical protein	NA	NA	NA	NA
WP_077733230.1\|453742_454864_-	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_077733231.1\|455983_456634_-	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_077733232.1\|456645_458049_-	3-isopropylmalate dehydratase large subunit	NA	NA	NA	NA
WP_077733233.1\|459077_460154_-	chorismate synthase	A0A291AU41	Pandoravirus	8.2e-75	41.8
459593:459608	attL	NA	NA	NA	NA
WP_077733234.1\|460222_461686_-	YdiU family protein	A0A075BSJ0	Microcystis_phage	4.7e-49	34.5
WP_077733235.1\|461694_462081_-	DUF2069 domain-containing protein	NA	NA	NA	NA
WP_077733236.1\|462157_463501_+	YihY family inner membrane protein	NA	NA	NA	NA
WP_077733237.1\|464000_465068_+	nitronate monooxygenase	NA	NA	NA	NA
WP_077734943.1\|465064_466042_-\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_077733238.1\|466212_467190_+	homoserine kinase	NA	NA	NA	NA
WP_077733239.1\|467193_467964_+	hypothetical protein	NA	NA	NA	NA
WP_077733240.1\|467944_468277_-	hypothetical protein	NA	NA	NA	NA
WP_159436809.1\|468261_469104_-	type II secretion system F family protein	NA	NA	NA	NA
WP_077733242.1\|469112_469961_-	type II secretion system F family protein	NA	NA	NA	NA
WP_077733243.1\|469973_471560_-	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_077733244.1\|471543_472917_-	pilus assembly protein N-terminal domain-containing protein	NA	NA	NA	NA
WP_159436810.1\|472900_473797_-	Flp pilus assembly protein CpaB	NA	NA	NA	NA
WP_077733246.1\|473808_474435_-	hypothetical protein	NA	NA	NA	NA
WP_077733247.1\|474444_475101_-	hypothetical protein	NA	NA	NA	NA
WP_077733248.1\|475100_476405_-	hypothetical protein	NA	NA	NA	NA
WP_077733249.1\|476407_476644_-	hypothetical protein	NA	NA	NA	NA
WP_077733250.1\|476868_478110_+\|integrase	integrase arm-type DNA-binding domain-containing protein	A0A2H4IYX8	uncultured_Caudovirales_phage	2.8e-42	28.9
WP_077733252.1\|478572_479037_+	hypothetical protein	NA	NA	NA	NA
WP_077733253.1\|479195_479564_+	hypothetical protein	NA	NA	NA	NA
WP_077733254.1\|479597_480074_-	DUF2514 family protein	NA	NA	NA	NA
WP_077733255.1\|480493_480709_-	hypothetical protein	NA	NA	NA	NA
WP_077733256.1\|480789_481080_-	hypothetical protein	B0ZSG7	Halomonas_phage	1.7e-06	37.3
WP_077733257.1\|481076_481385_-	hypothetical protein	NA	NA	NA	NA
WP_077733258.1\|481381_483088_-	hypothetical protein	A0A1S5R1J5	Pseudomonas_phage	3.9e-18	46.6
WP_159436811.1\|483077_483254_-	hypothetical protein	NA	NA	NA	NA
WP_149026076.1\|483283_483472_-	hypothetical protein	NA	NA	NA	NA
WP_077733259.1\|483449_483839_-	hypothetical protein	NA	NA	NA	NA
WP_077733260.1\|483835_488308_-	DUF1983 domain-containing protein	A4JX16	Burkholderia_virus	6.7e-187	45.3
WP_077733261.1\|488319_488667_-	hypothetical protein	Q8W6T0	Burkholderia_virus	1.3e-18	56.3
WP_077733262.1\|488663_489254_-\|tail	tail assembly protein	F1C572	Cronobacter_phage	1.2e-32	46.4
WP_077733263.1\|489250_490012_-	C40 family peptidase	A0A2I6PI52	Pseudomonas_phage	2.6e-51	42.0
WP_077733264.1\|490014_490722_-\|tail	phage minor tail protein L	A0A1S5R1H6	Pseudomonas_phage	9.3e-43	38.6
WP_077733265.1\|490718_491066_-\|tail	phage tail protein	A0A1W6JP11	Morganella_phage	2.4e-15	38.3
WP_159436812.1\|491068_492478_-	hypothetical protein	H2BD91	Pseudomonas_phage	7.2e-63	45.5
WP_077733267.1\|492801_494169_-	tape measure protein	J7HXG0	Pseudomonas_phage	3.9e-53	38.7
WP_077733268.1\|494228_494588_-	hypothetical protein	NA	NA	NA	NA
WP_077733270.1\|494953_495553_-	hypothetical protein	J7I4I5	Pseudomonas_phage	3.0e-50	55.2
WP_077733271.1\|495549_496284_-\|tail	phage tail protein	A0A125RNN0	Pseudomonas_phage	7.1e-70	57.8
WP_077733272.1\|496295_496643_-	hypothetical protein	J7I407	Pseudomonas_phage	5.8e-22	46.8
WP_077733273.1\|497091_497361_-	hypothetical protein	NA	NA	NA	NA
WP_077733274.1\|497357_497678_-	hypothetical protein	J7I4I8	Pseudomonas_phage	1.6e-39	73.6
WP_077733275.1\|497677_498079_-	hypothetical protein	A0A125RNM6	Pseudomonas_phage	1.7e-49	68.9
WP_077733276.1\|498150_498354_-	hypothetical protein	G0ZNE0	Cronobacter_phage	6.6e-10	64.0
WP_077733277.1\|498363_499434_-	hypothetical protein	A0A125RNM3	Pseudomonas_phage	1.2e-142	70.2
WP_077733278.1\|499446_499890_-	hypothetical protein	A0A1V0E5Q8	Salmonella_phage	2.4e-57	78.8
WP_077733279.1\|499892_500957_-	hypothetical protein	H6WRT2	Salmonella_phage	6.0e-110	53.5
WP_149026078.1\|500960_501785_-\|head	phage head morphogenesis protein	J7HX92	Pseudomonas_phage	1.1e-87	60.4
WP_077733281.1\|501822_503190_-	DUF1073 domain-containing protein	I6R9A1	Salmonella_phage	2.5e-161	62.2
502731:502746	attR	NA	NA	NA	NA
WP_077733282.1\|503246_504512_-\|terminase	PBSX family phage terminase large subunit	A0A125RNL7	Pseudomonas_phage	9.6e-200	81.2
WP_077733283.1\|504492_505101_-\|terminase	terminase small subunit	U5PZD3	Bacillus_phage	7.3e-28	40.6
WP_077733284.1\|505169_505976_-	hypothetical protein	NA	NA	NA	NA
WP_077733285.1\|506027_506354_-	hypothetical protein	NA	NA	NA	NA
WP_077733286.1\|506441_506852_-	hypothetical protein	NA	NA	NA	NA
WP_077733288.1\|507339_507705_-	hypothetical protein	NA	NA	NA	NA
WP_077733290.1\|507885_508539_-	hypothetical protein	Q3HQZ7	Burkholderia_phage	1.6e-65	61.1
WP_077733291.1\|508531_509434_-	hypothetical protein	Q7Y5W1	Haemophilus_phage	3.1e-19	45.1
WP_077734944.1\|509430_509793_-	recombinase	A0A222YXV2	Escherichia_phage	4.2e-15	41.2
WP_077733292.1\|509909_510350_-	recombination protein NinB	K4NZ61	Pseudomonas_phage	3.8e-10	36.7
WP_077733293.1\|510476_510920_-	hypothetical protein	J7I4J9	Pseudomonas_phage	2.0e-19	49.6
WP_173834762.1\|510974_511169_+	hypothetical protein	NA	NA	NA	NA
WP_077733294.1\|511104_511368_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_149026080.1\|511421_512165_+	helix-turn-helix domain-containing protein	A0A0U4JEE2	Pseudomonas_phage	3.7e-18	31.2
WP_077733296.1\|512244_512883_+	hypothetical protein	A0A141GF23	Brucella_phage	4.8e-14	28.3

DBSCAN-SWA_4

605963 : 613432

Methanothermobacter_phage(16.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077733371.1\|605963_607166_+	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	Q9HH70	Methanothermobacter_phage	1.2e-37	30.4
WP_077733372.1\|607184_607634_+	dUTP diphosphatase	S4TNT3	Salmonella_phage	9.7e-46	68.4
WP_077733373.1\|607699_610042_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	4.9e-165	41.1
WP_077733374.1\|610136_610373_-\|protease	ATP-dependent Clp protease adaptor ClpS	NA	NA	NA	NA
WP_173834797.1\|610701_610854_+	cold-shock protein	Q9AZD3	Lactococcus_phage	1.2e-08	63.6
WP_077733375.1\|610879_611335_+	DUF192 domain-containing protein	A0A222YVT9	Synechococcus_phage	5.1e-10	42.0
WP_077733376.1\|611470_612673_-	3-oxoadipyl-CoA thiolase	NA	NA	NA	NA
WP_077733377.1\|612853_613432_-	superoxide dismutase [Fe]	Q56AR7	Bacillus_thuringiensis_phage	1.6e-37	39.7

DBSCAN-SWA_5

1902809 : 1912599

Acinetobacter_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_077734309.1\|1902809_1904003_+	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	4.2e-64	37.9
WP_077734310.1\|1904049_1904922_+	D-amino acid aminotransferase	NA	NA	NA	NA
WP_077734311.1\|1904923_1905196_+	DUF493 family protein	NA	NA	NA	NA
WP_077734312.1\|1905212_1905884_+	lipoyl(octanoyl) transferase LipB	NA	NA	NA	NA
WP_077734313.1\|1905876_1906860_+	lipoyl synthase	NA	NA	NA	NA
WP_077735011.1\|1906919_1907681_-	uracil-DNA glycosylase	A0A0B4Q626	Equid_gammaherpesvirus	1.9e-41	45.4
WP_077734314.1\|1907702_1908494_-	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	1.2e-70	56.3
WP_077735012.1\|1908490_1909522_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	5.8e-70	42.0
WP_077734315.1\|1909546_1910110_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.3e-67	61.8
WP_077734316.1\|1910159_1911677_-	anthranilate synthase component I	S4VNU7	Pandoravirus	1.1e-40	31.7
WP_077734317.1\|1911912_1912599_-	phosphoglycolate phosphatase	M1I5S4	Acanthocystis_turfacea_Chlorella_virus	4.5e-10	26.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019697

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection