CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP019841	Enterobacter roggenkampii strain R11 plasmid pASM2, complete sequence	0 crisprs	NA	0	1
NZ_CP019840	Enterobacter roggenkampii strain R11 plasmid pASM1, complete sequence	1 crisprs	NA	1	1
NZ_CP019843	Enterobacter roggenkampii strain R11 plasmid pASM4, complete sequence	0 crisprs	NA	0	0
NZ_CP019839	Enterobacter roggenkampii strain R11 chromosome, complete genome	1 crisprs	DinG,PD-DExK,DEDDh,cas3,csa3,WYL	7	4
NZ_CP019842	Enterobacter roggenkampii strain R11 plasmid pASM3, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

24832 : 59443

Morganella_phage(22.22%)

transposase,tail,integrase,protease

attL 22459:22473|attR 28855:28869

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
22459:22473	attL	NA	NA	NA	NA
WP_004187383.1\|24832_25573_-\|integrase	tyrosine-type recombinase/integrase	I3WFA4	Macacine_betaherpesvirus	9.5e-22	51.6
WP_020316874.1\|25591_25795_-	hypothetical protein	NA	NA	NA	NA
WP_004187390.1\|25836_26322_-	hypothetical protein	NA	NA	NA	NA
WP_004206901.1\|26318_26906_-	restriction endonuclease	NA	NA	NA	NA
WP_004187394.1\|26898_27147_-	helix-turn-helix transcriptional regulator	A0A248SLB9	Klebsiella_phage	1.6e-10	53.0
WP_044068872.1\|27143_27605_-	hypothetical protein	NA	NA	NA	NA
WP_004206899.1\|27745_28291_+	hypothetical protein	NA	NA	NA	NA
WP_004206898.1\|28443_28851_-	hypothetical protein	NA	NA	NA	NA
WP_015062853.1\|28852_29431_-	hypothetical protein	NA	NA	NA	NA
28855:28869	attR	NA	NA	NA	NA
WP_004206896.1\|29408_29765_-	hypothetical protein	NA	NA	NA	NA
WP_128697084.1\|31498_32206_-	hypothetical protein	A0A2D1GNW5	Pseudomonas_phage	1.1e-19	40.7
WP_044068877.1\|32394_34512_-\|tail	phage tail tape measure protein	A0A0M3LPB6	Mannheimia_phage	1.1e-43	30.2
WP_044068879.1\|34781_35687_-	hypothetical protein	A0SMP3	Pseudomonas_virus	4.6e-63	42.8
WP_044068880.1\|35909_36224_-	hypothetical protein	NA	NA	NA	NA
WP_044068881.1\|36213_36405_-	host cell division inhibitor Icd-like protein	NA	NA	NA	NA
WP_044068883.1\|36598_36793_+	DUF3950 domain-containing protein	A0A0K2FIR8	Escherichia_phage	1.6e-05	41.4
WP_060437097.1\|36799_36994_-	hypothetical protein	NA	NA	NA	NA
WP_004886861.1\|37449_37731_+	peptidylprolyl isomerase PpiC	NA	NA	NA	NA
WP_020323220.1\|37807_39283_-	ketol-acid reductoisomerase	NA	NA	NA	NA
WP_009654922.1\|39558_40461_+	HTH-type transcriptional activator IlvY	NA	NA	NA	NA
WP_009654925.1\|40581_41586_+	dihydroxyacetone kinase subunit DhaK	NA	NA	NA	NA
WP_009654921.1\|41587_42217_+	dihydroxyacetone kinase subunit L	NA	NA	NA	NA
WP_032449369.1\|42434_43628_+	trans-2-enoyl-CoA reductase family protein	NA	NA	NA	NA
WP_009654924.1\|43761_44028_-	HPr family phosphocarrier protein	NA	NA	NA	NA
WP_009654926.1\|44043_44685_-	DAK2 domain-containing protein	NA	NA	NA	NA
WP_009654928.1\|44694_45708_-	dihydroxyacetone kinase subunit DhaK	NA	NA	NA	NA
WP_000156887.1\|46281_47304_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_001515348.1\|47905_48478_+	cytochrome b/b6 domain-containing protein	NA	NA	NA	NA
WP_048286540.1\|48677_49601_+	cation transporter	NA	NA	NA	NA
WP_001567361.1\|49857_50499_-	recombinase family protein	NA	NA	NA	NA
WP_054623389.1\|50666_53732_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	4.3e-294	53.3
WP_000156887.1\|53728_54751_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_004206893.1\|55045_55729_+	hypothetical protein	NA	NA	NA	NA
WP_004187411.1\|55773_55992_+	hypothetical protein	NA	NA	NA	NA
WP_004187413.1\|55994_56204_+	hypothetical protein	NA	NA	NA	NA
WP_024190314.1\|56326_57592_-	translesion error-prone DNA polymerase V subunit UmuC	A0A1W6JNT0	Morganella_phage	1.3e-111	50.4
WP_044068898.1\|57579_58014_-	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A1W6JNS2	Morganella_phage	3.6e-29	54.5
WP_020277900.1\|58106_58472_-	type II toxin-antitoxin system toxin endoribonuclease PemK	NA	NA	NA	NA
WP_004187429.1\|58440_58698_-	type II toxin-antitoxin system antitoxin PemI	NA	NA	NA	NA
WP_004206890.1\|58789_59443_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP019840

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019840_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019840_1

70292-70426

Orphan

Consensus_repeat	Method
TGGAATATCGATTCCACACGCCGGATTTAACTGGGACCACGGTCCCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019840_1

>merge|NZ_CP019840|1|70292-70426|CRISPRCasFinder
TGGAATATCGATTCCACACGCCGGATTTAACTGGGACCACGGTCCCACCTCCTACTTGCGTGTCAGAACTCATCCTTCAACCCCGCCTGGAATATCGATTCCACACGCCGGATTTAACTGGGACCATGGTCCCAC

>NZ_CP019840|1|1|70292-70426|CRISPRCasFinder
TGGAATATCGATTCCACACGCCGGATTTAACTGGGACCACGGTCCCAC	CTCCTACTTGCGTGTCAGAACTCATCCTTCAACCCCGCC
TGGAATATCGATTCCACACGCCGGATTTAACTGGGACCATGGTCCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019840.1\|WP_039025473.1\|67821_68988_+\|plasmid-partitioning-protein-SopA	unknown	unknown	gnl\|CDD\|184261
NZ_CP019840.1\|WP_164722686.1\|75824_77039_-\|type-II-site-specific-deoxyribonuclease	unknown	unknown	gnl\|CDD\|370247
NZ_CP019840.1\|WP_039025472.1\|66070_67081_-\|replication-initiation-protein	unknown	unknown	gnl\|CDD\|376444
NZ_CP019840.1\|WP_084832861.1\|79297_79966_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NZ_CP019840.1\|WP_058842236.1\|60387_63069_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|213207
NZ_CP019840.1\|WP_039025123.1\|80913_81072_+\|type-I-toxin-antitoxin-system-Hok-family-toxin	unknown	unknown	gnl\|CDD\|182055
NZ_CP019840.1\|WP_084833188.1\|77187_79314_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271187
NZ_CP019840.1\|WP_013087134.1\|68987_69953_+\|ParB/RepB/Spo0J-family-plasmid-partition-protein	unknown	unknown	gnl\|CDD\|184254
NZ_CP019840.1\|WP_045355004.1\|56837_57788_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019840.1\|WP_045286915.1\|71899_74038_+\|ATPase-AAA	unknown	unknown	gnl\|CDD\|213202
NZ_CP019840.1\|WP_013087127.1\|64042_64573_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019840.1\|WP_013087126.1\|63621_63912_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019840.1\|WP_000019445.1\|58086_59067_-\|IS5-like-element-ISKpn26-family-transposase	unknown	unknown	gnl\|CDD\|225581
NZ_CP019840.1\|WP_039025471.1\|64591_65368_+\|phage-integrase-family-protein	unknown	unknown	gnl\|CDD\|334163
NZ_CP019840.1\|WP_045332705.1\|82859_83060_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019840.1\|WP_084833190.1\|82310_82772_+\|DUF1419-domain-containing-protein	unknown	unknown	gnl\|CDD\|369265
NZ_CP019840.1\|WP_084833191.1\|83100_83892_+\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|280533
NZ_CP019840.1\|WP_072268114.1\|74387_75791_+\|DNA-cytosine-methyltransferase	unknown	unknown	gnl\|CDD\|236696
NZ_CP019840.1\|WP_008502222.1\|56163_56406_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019840.1\|WP_084833189.1\|81936_82251_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019840.1\|WP_039025473.1\|67821_68988_+\|plasmid-partitioning-protein-SopA	gnl\|CDD\|184261	PRK13705, PRK13705, plasmid-partitioning protein SopA; Provisional.	0
NZ_CP019840.1\|WP_164722686.1\|75824_77039_-\|type-II-site-specific-deoxyribonuclease	gnl\|CDD\|370247	pfam09019, EcoRII-C, EcoRII C terminal. The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites.	6.70144e-90
NZ_CP019840.1\|WP_039025472.1\|66070_67081_-\|replication-initiation-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	0.000178458
NZ_CP019840.1\|WP_084832861.1\|79297_79966_-\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	3.76586e-28
NZ_CP019840.1\|WP_058842236.1\|60387_63069_-\|AAA-family-ATPase	gnl\|CDD\|213207	cd03240, ABC_Rad50, ATP-binding cassette domain of Rad50. The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.	0.00022638
NZ_CP019840.1\|WP_039025123.1\|80913_81072_+\|type-I-toxin-antitoxin-system-Hok-family-toxin	gnl\|CDD\|182055	PRK09738, PRK09738, small toxic polypeptide; Provisional.	7.30258e-24
NZ_CP019840.1\|WP_013087134.1\|68987_69953_+\|ParB/RepB/Spo0J-family-plasmid-partition-protein	gnl\|CDD\|184254	PRK13698, PRK13698, ParB/RepB/Spo0J family plasmid partition protein.	0
NZ_CP019840.1\|WP_084833188.1\|77187_79314_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271187	cd01187, INT_tnpB_C_Tn554, Putative Transposase B from transposon Tn554, C-terminal catalytic domain. This family includes putative Transposase B from transposon Tn554. It belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	2.43713e-15
NZ_CP019840.1\|WP_045286915.1\|71899_74038_+\|ATPase-AAA	gnl\|CDD\|213202	cd03235, ABC_Metallic_Cations, ATP-binding cassette domain of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.	1.30885e-05
NZ_CP019840.1\|WP_000019445.1\|58086_59067_-\|IS5-like-element-ISKpn26-family-transposase	gnl\|CDD\|225581	COG3039, COG3039, Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair].	6.92885e-54
NZ_CP019840.1\|WP_039025471.1\|64591_65368_+\|phage-integrase-family-protein	gnl\|CDD\|334163	pfam00589, Phage_integrase, Phage integrase family. Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.	8.99879e-39
NZ_CP019840.1\|WP_084833190.1\|82310_82772_+\|DUF1419-domain-containing-protein	gnl\|CDD\|369265	pfam07215, DUF1419, Protein of unknown function (DUF1419). This family consists of several bacterial proteins of around 110 residues in length. Members of this family seem to be specific to Agrobacterium species and to Rhizobium loti. The function of this family is unknown.	0.00107459
NZ_CP019840.1\|WP_084833191.1\|83100_83892_+\|N-6-DNA-methylase	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	2.06487e-10
NZ_CP019840.1\|WP_072268114.1\|74387_75791_+\|DNA-cytosine-methyltransferase	gnl\|CDD\|236696	PRK10458, PRK10458, DNA cytosine methylase; Provisional.	0

>NZ_CP019840.1|WP_013087134.1|68987_69953_+|ParB/RepB/Spo0J-family-plasmid-partition-protein
MKRAPVIPKHTVKDIRPETEPSAAPAAPMVDSLIARVGAMARGNTILLPVCGREVKFILEAIPGESVETASRVWSGNERDQELLTEDALDDLIPSFMLSGQQTPAFGRRVEGVIEIADGSRRRKAAILTSSDYRVLVGDLDDEQMMALSRLGNDYRPVSAYERGNRYAQRLENDFNGNISALAEAENISRKIITRCINTAHLPKSVVALFTHPGELSARSGETLYKAFSGKEALLLQRTQQLHEQKKAGVIFESEEVIGLLTDVLKEPSGKKVNLNTRHQFVPGATALYKGDKVIFNLDKSRLPAECIEKIESILRDLQKV
>NZ_CP019840.1|WP_039025473.1|67821_68988_+|plasmid-partitioning-protein-SopA
MGLMETLDQCITAGHEMTKAIAIAQFNDDSPEARKITRRWRVGEAADLIGVSSQAIRDAEKAGRLPHPDMEMRGRVEQRVGYTIEQINLMRDVFGTRLRRPDDSVPPVIAVAAHKGGVYKTSVSVHLAQDLALKGLRVLLVEGNDPQGTASMYHGWVPDLHIHAEDTLLPFYLGERDDAAYAVKATCWPGLDIIPSCLALHRIETELMGRFDNGKLPTEPHMMLRLAIETVAHDYDVIVIDSAPNLGIGTINVVCAADVLIVPTPAELFDYTSALQFFDMLRDLLKNVDLQGFEPDVRILLTKYSNNNGSQSPWMEEQIRDAWGSMVLKNVVRETDEVGKGQIRMRTVFEQAIDQRSSTGAWRNALSIWEPVCNEIFDRLIKPRWEIR
>NZ_CP019840.1|WP_039025472.1|66070_67081_-|replication-initiation-protein
MAMENNELPLNLQEVNKTTGEVVKLDVNSASTVQPVALMRLGLFVPTLKSTSRSKTNRKNVTDATEELVQLSIARSEGYTDVRITGSRLDMDTDFKVWLGIIRSMYDFGVKDDTLKLSFVEFVKMCGFDSRRSNKKMRDRISNSLFKLASVTLKFQSETKGWTTHLVQSAYYDITADVVEIRAEPNLFELYQMDRRVLLRLKAIDALQRKESAQALYTYIESLPQNPAPISMKRMRDRLNLTSNLYTQNHTVRKAMAQLKDIGYLDYTEFKRGRATYFSVHYRNPKLISSKVVVPREPEEEVPEQNYDEVIKALKAAGIDPQKLAKALASVKPGND
>NZ_CP019840.1|WP_039025471.1|64591_65368_+|phage-integrase-family-protein
MMPALPGHSGAFSSAQLPVVIDYPAALALRQMALVQDELPKYLLAPEVSALLHYVPDLHRKMLLTTLWNTGARINEALALTRSDFSLAPPYPFVQLATLKQRVEKAARTAGRAPAGSQPHRNVPLSDPQYARQLEMMVATLKIPLERRNKRTGRTEKVRIWEITDRTVRTWLGEAVEAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSISSTEVYTKVFALDVAARHRVQFSMAEADAVAMLKKR
>NZ_CP019840.1|WP_013087127.1|64042_64573_+|hypothetical-protein
MCKLTGFIMGLTILLGVTARDAGAATLSEMRMVNASQKPGMVIICSRTSEIPQKGESPVRIESLLRGVVLQNDGDRMMFDVTYTQRNAEESIPFRTEKYRLTTELEATRQKMAIDPETIELSLPRARGLEETFLAGMKASPVSFEDYTNYRVKSATEYLILPGPASPDAPVMHCTL
>NZ_CP019840.1|WP_013087126.1|63621_63912_+|hypothetical-protein
MNMKITLSVLFEALIILGHDRVWMEESEFEHIYGYGCYREIHTWDDRTVAWWDDADDTWYLSTEVDVITPFLGPLPKKEGELSEEKCFQLMTLGRY
>NZ_CP019840.1|WP_058842236.1|60387_63069_-|AAA-family-ATPase
MKGSEWNKWDLHIHSPVTWQANGYAGQCDIARYVQLLGEKQLSLIAVTNYFYFRQNELEIIREEIARQNLNITVLGNVEFRLDQQNKAGDFINVHILFSDRISTERINEALSRFPLRLTDGDRKAIYCCEKSVADSGHGVDTIVVAFSALLEHLSASFRPFRDYLVAVCPNGYGGYRPDANGRSAAIATEIDRQGQMIFGGKGDREFFLRTDRYDGASVKPVFLCSDAHRMEDIGGRYTWVKALPTFEGLRQALLEPEARLRIGEEWLAELTPKAHFSQIDVEGTIFDGQEISFRKLSIPLSQDMVAIIGGRGTGKSLLLDALRSRFAGAAARGSDQRDVNVQHMSIELDKANGEKIRFDTRSEGYEYLHVSQGEIKKLCQEPGLISDEIKKMLRLTPTHEAGNTAAQLAENLSAWRAWREFSLFRSAHSEPVNTRHFQLNIIRAAQEKIEVLTSDRNKALIETFRENSRRQTLLLQTRDKLTGVRADIVTAAEDLNARIAAINAEDTAHEAIPLVDLSAQTGVIERRLLSVQEQTEQFGRDNDEIIGAFREQGLGQDITGLLEKVHEYQRQTELAETHLREIGHQETLYRSGLEQRTRLAAEFMDGLLSRQGVIDTAFASLTTKPHLTQDQQALIQDILTDIRIYGQPHFDVTAFYNGMLSCLNRGRFRAAGELTTQDRLREVFRISSIDEFRALLANEPMLVLPECPDNKLTLEAFFWRDEYFNSQGPDALLSYLFSPEQIQRYLNVRAEFEYKGKTVEKLSAGQRGTFYVCLKLATDAFGSPFVFDQPEDDLDNDFIMHSLVPLFRKIKQYRQVIIVTHNANLVVNCDAEQVIIAANNDEVISYRSGALEYGDHGAPNSMRKAICDVLEGGRQAFEAREQKYGMLWLNAI
>NZ_CP019840.1|WP_000019445.1|58086_59067_-|IS5-like-element-ISKpn26-family-transposase
MSHQLTFADSEFSTKRRQTRKEIFLSRMEQILPWQNMTAVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVKTLKQHPRKNKTAINIEYMKASIRARVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRVDQMIRQWERSQ
>NZ_CP019840.1|WP_045355004.1|56837_57788_+|hypothetical-protein
MFNLRVKTWEDWETLCIYWMKEIAWWGHRVDTNYQTYGRPGQKQHGVDIKPVLPGCGIVGQSKFIQGSFTLKDLNAELDKTDNYPGPITNYYLLTTAEKCTSIQNASSYERISHTRQDGSFFYVDVYYWSDRINVDFLPKEVKYNLFPEAKTLFDTESEKSTNNSSTLSPDVMLDKLDKLKRLIRNTFSEENIKWLETWNFRSYKIYSRDYDVFNMAYLDWTMIEVAMRTNNPKVLRAYLNNASRINFYATWPVSQAFFYALEEFRKIAYNHYNTGALDGDETFLTVSDLKHRDSIAHQMECAASYLSQVIRNIQQ
>NZ_CP019840.1|WP_008502222.1|56163_56406_-|hypothetical-protein
MKNTSRKIKITYDDLMNITAMSIETITGIQGRVQLSENELGILRGIILHWRALASQFGISTENLDRDMDWLCELAGIPVN
>NZ_CP019840.1|WP_045286915.1|71899_74038_+|ATPase-AAA
MDVEINYCNNIDNACITLSENKLNIKFAPNGTGKSTISRAILHSVSRDAAGLNSLLPFKFRAANPDEFQPSVTGTEQIQDVMCFDEKYVSQFTFQPDELISNSFDIFIKTEAYNQTEREIDSMVMAIRQEFSGNDELELFITHLQELSGAFKLTSKGLSKASTGMKGLAGGNKLQHIPSGLEPYQPFIQSPRNVEWIEWQTKGYENFCSLSEGCCPFCTGDSHEKAEQISKVSAEYDKAVIKNLVGIITVLDKLGEYFSEAARSRLREITTLQGGLEKKHEDYLVTVKQQTENLLAMLLTLKTLNSFTFNDAGNIRASLASFRLDVKYFSELQSDKTLATIGRLNASLDSLISQAGLLQGQINKQRAGMQRLIQKHKKDINTFLAYAGYRYQVDISGDGEQCRLKLRHVDYTDYLSGGSQHLSYGERNAFSIVLFMYECLARKPNLIILDDPISSFDKNKKFAILEMLFRRDSSECLKNQTVLMLTHDVEPIIDTLKSVKKLFSNQVTASYLRYSTGTITELPIRESDILTFAQICKVVLESDCDDLIKLIYLRRHYEIMDNRGDVYQVLSNLFHRREEPIDTRLPLIEGTGYPMMDPESFLNGCSLITKNIFGFDYPHMLSLLNDPDKILSLYRSCTNGYEKLQVFRLLEPEADNRVIRKFVNETYHIENEFICQLDPTRFDLIPEYVIVECDRLLLNIEASNDDAELETA
>NZ_CP019840.1|WP_072268114.1|74387_75791_+|DNA-cytosine-methyltransferase
MLEKAEAEEQLRQENDKKLLGQVLEIYDQKYVAELLRKVGKNEWSRETLNRWINGKCSPKSLTLAEEELLRKMLPEAPAHHPDYAFRFIDLFAGIGGIRKGFETIGGQCVFTSEWNKEAVRTYKANWFNDAQEHTFNLDIREVTLSDKPEVPENDAYAYINEHVPDHDVLLAGFPCQPFSLAGVSKKNSLGRAHGFECEAQGTLFFDVARIIRAKKPAIFVLENVKNLKSHDKGKTFKVIMDTLDELGYEVADAAEMGKNDPKVIDGKHFLPQHRERIVLVGFRRDLNIHQGFTLRDISRFYPEQRPSFGELLEPVVDSKYILTPKLWEYLYNYAKKHAAKGNGFGFGLVNPENKESIARTLSARYHKDGSEILIDRGWDMATGETDFANEENQAHRPRRLTPRECARLMGFEKVDGRPFRIPVSDTQSYRQFGNSVVVPVFEAVAKLLEPYILKAVYADSCKVERI
>NZ_CP019840.1|WP_164722686.1|75824_77039_-|type-II-site-specific-deoxyribonuclease
MLMSVFHNWLLEMACENYFVYIKRLSANDTGATGGHQVGLYIPSGIVEKLFPSINHTRELNPSVFLTAHVSSHDCPDSEARAIYYNSRHFGKTRNEKRITRWGRGSPLQDPENTGALTLLAFKLDEQGGDCKEVNIWVCASTDEEDVIETAIGEVIPGALISGPAGQILGGLSLQQAPVNHKYILPEDWHLRFPSGSEIIQYAASHYVKNSLDPDEQLIDRRRVEYDIFLLVEELHVLDIIRKGFGSVDEFIALANSVSNRRKSRAGKSLELHLEHLFIEHGLRHFATQAVTEGNKKPDFLFPSAGAYHDTEFPVENLRMLAVKTTCKDRWRQILNEADKIHQVHLFTLQEGVSLAQYREMRESGVRLVVPSSLHKKYPEAVRAELMTLGAFIAELTGLYADIP
>NZ_CP019840.1|WP_084833188.1|77187_79314_-|tyrosine-type-recombinase/integrase
MTGKRDKGFIYAHFCRADYDLHAGFSSEQKEALSTSHKRSRNYGRSGSLSSLITPLLDIANNSGTGCRLTRTVIMAMLTEMQNVGQPCWNWREDQWISLFDKYRRGKPLMMAFAYHLGPFTSPLQIPHENTLSLYASAIYGNAIFRDQLNRLSEALISLGYSPQHLRHAVSSPLGLLMLLNDNPRLEDMTTELLWQAQQYHDKRVSRHVGKISHGLAALGIIAKPVRMRNHTEWHEKPVENISPEWVAWCRRWRETSVLRPRTRENQYSFILRCGLWLAKEHPEVKVPTDWSIETCASFIAAVGRMKVDELSLGTEHGLRKSKRSGEPMMPHSRAHFIYSLRRFMSDFELWGWGRLNFSPARHLFTPDTPLFRRGVNPRVIDDPVWLKLIWASLNLRHEDLLSEIHYPLSMLQAMAVIWTHAGLRQNELLRLTMECVTPQSEDIIREDGSVVPAGTLCYLNVPAGKTSKAFVKPVSVIVKKYVDIWLNVRPVDQAKLNDDRTGEKVRYLFQYRGKPAGSDVINRTVIPVLCARAGLPVEDSGGAITSHRGRASALTALASVPQGMSLYELMQWSGHSSPQSTLHYIRIRPTQLAASFVKADRIAHMISVLVDHDPEAVSPTGPATYYDLGESFCMNPFWSSCPHRMACIGCDFNLLKDSARGLMLESKTSIRRYLEEVPLTPDEKAIVEQDIKKVEQALAKLTGKSGG
>NZ_CP019840.1|WP_084832861.1|79297_79966_-|site-specific-integrase
MNKLGPLPVQRITRLPQIPDDGQWYHLLGYISDCSLRDRLMLALAYHGALRRSEVTTITIEDIDPAHRLIRIRAENTKGKRERVVCYGPAITPVLAAHLRNLRQTGITGGALFRSFSDRNYGSPLSYWSWSKTVREWSDRTNMPFLTTHTFRHLRLTHLARAGWKLHEIATYAGHRDLRTTQIYIHLSGTDLAARMAMTVAETDRKIAAIMFGQERENDRQA
>NZ_CP019840.1|WP_039025123.1|80913_81072_+|type-I-toxin-antitoxin-system-Hok-family-toxin
MKLPRNTLLWCVLIVCLTLLVFTYLTRKSLCEIRYRDTNREVAAFMAYESAK
>NZ_CP019840.1|WP_084833189.1|81936_82251_+|hypothetical-protein
MHTRNVNVKTAGGESSRKMGGKTVSYTILVAETKKNSDEETDVLEFSSLAELKKLRRSCPETMRCTYFYALSSGVDKQFRHIHVAEADHFKQFVRLIERAGIDI
>NZ_CP019840.1|WP_084833190.1|82310_82772_+|DUF1419-domain-containing-protein
MNVNTPTAAPMAFFVPSHNAVYDRATQLEGQWVTQREAITLESLRRLYPDAELIPATLVQEKQNDGYRRPWVEITEARYIDQMETLPPVDWCRGYGGESFKSMEFTGGDVTAIFVRYGARFFECYDLHTRHHRELIGDVIARFCLDAPLNSAH
>NZ_CP019840.1|WP_045332705.1|82859_83060_+|hypothetical-protein
MNFDPQTVAQAKAFVNALRAGKRARVPALRFSQWQPFLSVVNAETGYAADADCGLAVSVYPALGLA
>NZ_CP019840.1|WP_084833191.1|83100_83892_+|N-6-DNA-methylase
MSQLSFESLFLADQADPQPWASDPVRVQSPAEARKQFASVFRQTAKYMRRSEVFRDFITLAASGLDIASIRSPESIENSRRICGRYQPEDLDAMRQLFCLLVEGLAGEMHDFLGAVYMEHELGADEMGQYFSPSSISRLMAGLLMPGAQETIKREGWMTLDEPACGSAGMVIAFAYWMAEAGYNPSEQLYATCTDIDPMVADMAFIQLSLLGIPAKVVTGNTLTLKANRVRYTPVYYFNDWQGRLEFRSRFEAMKNFLATVAA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP035636	Enterobacter cloacae strain EN3600 plasmid unnamed4, complete sequence	100226-100264	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP017182	Enterobacter kobei strain DSM 13645 plasmid pDSMZ13645, complete sequence	1315-1353	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP017182	Enterobacter kobei strain DSM 13645 plasmid pDSMZ13645, complete sequence	1402-1440	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP031569	Enterobacter hormaechei strain 2013_1a plasmid pIncFIB-1301491, complete sequence	7815-7853	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP050011	Citrobacter sp. Y3 plasmid unnamed2, complete sequence	27572-27610	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP019840	Enterobacter roggenkampii strain R11 plasmid pASM1, complete sequence	70340-70378	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP022149	Enterobacter roggenkampii strain 704SK10 plasmid p704SK10_1, complete sequence	50338-50376	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP009855	UNVERIFIED_ORG: Enterobacter cloacae strain ECNIH5 plasmid pENT-22e, complete sequence	14593-14631	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP008907	Enterobacter hormaechei subsp. hoffmannii ECR091 plasmid pENT-4bd, complete sequence	83191-83229	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP026851	UNVERIFIED_ORG: Enterobacter cloacae strain AR_0072 plasmid unnamed1	65584-65622	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_LT991956	Enterobacter hormaechei subsp. steigerwaltii isolate C309 plasmid pC309-p2	52487-52525	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP029719	UNVERIFIED_ORG: Enterobacter cloacae strain AR_0154 plasmid unnamed1, complete sequence	1341-1379	0	1.0
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP012428	Klebsiella pneumoniae strain KP5 plasmid pSg1-2, complete sequence	20127-20165	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NC_014107	Enterobacter cloacae subsp. cloacae ATCC 13047 plasmid pECL_A, complete sequence	48095-48133	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP046273	Enterobacter hormaechei strain E70 plasmid pE70-sul2, complete sequence	40032-40070	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP012169	Enterobacter hormaechei subsp. steigerwaltii strain 34998 plasmid p34998-210.894kb, complete sequence	40032-40070	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP042541	Enterobacter hormaechei strain C4 plasmid pC4_001, complete sequence	40032-40070	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP031723	Enterobacter hormaechei strain WCHEH020038 plasmid p2_020038, complete sequence	50311-50349	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP042567	Enterobacter hormaechei strain C44 plasmid pC44_001, complete sequence	40032-40070	1	0.974
NZ_CP019840_1	1.1\|70340\|39\|NZ_CP019840\|CRISPRCasFinder	70340-70378	39	NZ_CP039454	Enterobacter bugandensis strain 220 plasmid pSurvcare220, complete sequence	72766-72804	2	0.949

1. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP035636 (Enterobacter cloacae strain EN3600 plasmid unnamed4, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

2. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP017182 (Enterobacter kobei strain DSM 13645 plasmid pDSMZ13645, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

3. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP017182 (Enterobacter kobei strain DSM 13645 plasmid pDSMZ13645, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

4. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP031569 (Enterobacter hormaechei strain 2013_1a plasmid pIncFIB-1301491, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

5. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP050011 (Citrobacter sp. Y3 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

6. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP019840 (Enterobacter roggenkampii strain R11 plasmid pASM1, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

7. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP022149 (Enterobacter roggenkampii strain 704SK10 plasmid p704SK10_1, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

8. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP009855 (UNVERIFIED_ORG: Enterobacter cloacae strain ECNIH5 plasmid pENT-22e, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

9. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP008907 (Enterobacter hormaechei subsp. hoffmannii ECR091 plasmid pENT-4bd, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

10. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP026851 (UNVERIFIED_ORG: Enterobacter cloacae strain AR_0072 plasmid unnamed1) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

11. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_LT991956 (Enterobacter hormaechei subsp. steigerwaltii isolate C309 plasmid pC309-p2) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

12. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP029719 (UNVERIFIED_ORG: Enterobacter cloacae strain AR_0154 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgcc	Protospacer
***************************************

13. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP012428 (Klebsiella pneumoniae strain KP5 plasmid pSg1-2, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

14. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NC_014107 (Enterobacter cloacae subsp. cloacae ATCC 13047 plasmid pECL_A, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

15. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP046273 (Enterobacter hormaechei strain E70 plasmid pE70-sul2, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

16. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP012169 (Enterobacter hormaechei subsp. steigerwaltii strain 34998 plasmid p34998-210.894kb, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

17. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP042541 (Enterobacter hormaechei strain C4 plasmid pC4_001, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

18. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP031723 (Enterobacter hormaechei strain WCHEH020038 plasmid p2_020038, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

19. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP042567 (Enterobacter hormaechei strain C44 plasmid pC44_001, complete sequence) position: , mismatch: 1, identity: 0.974

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtgtcagaactcatccttcaaccccgtc	Protospacer
*************************************.*

20. spacer 1.1|70340|39|NZ_CP019840|CRISPRCasFinder matches to NZ_CP039454 (Enterobacter bugandensis strain 220 plasmid pSurvcare220, complete sequence) position: , mismatch: 2, identity: 0.949

ctcctacttgcgtgtcagaactcatccttcaaccccgcc	CRISPR spacer
ctcctacttgcgtttcagaactcatccgtcaaccccgcc	Protospacer
************* ************* ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

8901 : 59067

Escherichia_phage(26.67%)

protease,transposase,integrase

attL 7483:7498|attR 14905:14920

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
7483:7498	attL	NA	NA	NA	NA
WP_039025121.1\|8901_9879_-\|integrase	tyrosine-type recombinase/integrase	A0A1P8DJ76	Virus_Rctr85	3.0e-47	39.4
WP_045337323.1\|11425_11830_-	H-NS histone family protein	NA	NA	NA	NA
WP_045295136.1\|12424_12913_-	tellurium resistance protein TerW	NA	NA	NA	NA
WP_045295134.1\|12915_14139_-	DUF4236 domain-containing protein	NA	NA	NA	NA
WP_045295132.1\|14149_15106_-	HpcH/HpaI aldolase/citrate lyase family protein	NA	NA	NA	NA
14905:14920	attR	NA	NA	NA	NA
WP_045295130.1\|15105_16185_-\|protease	cysteine protease StiP family protein	A0A172Q0S8	Acinetobacter_phage	5.6e-39	35.3
WP_045337322.1\|16186_16960_-	hypothetical protein	NA	NA	NA	NA
WP_045337321.1\|16952_18095_-	adenine/guanine phosphoribosyltransferase	A0A172Q0Y1	Acinetobacter_phage	1.6e-31	34.5
WP_045337319.1\|18103_19162_-	carbamoyl-phosphate synthase large chain	NA	NA	NA	NA
WP_045295122.1\|19488_20070_+	tellurium resistance protein TerZ	K4JRX3	Caulobacter_phage	2.0e-11	30.2
WP_045295120.1\|20069_21239_+	tellurium resistance protein TerA	NA	NA	NA	NA
WP_045295118.1\|21261_21717_+	tellurite resistance TerB family protein	NA	NA	NA	NA
WP_045295116.1\|21740_22781_+	TerC/Alx family metal homeostasis membrane protein	K7QKE8	Escherichia_phage	2.5e-76	48.7
WP_045295115.1\|22829_23408_+	tellurium resistance membrane protein TerD	K4JRX3	Caulobacter_phage	3.0e-31	39.8
WP_045295113.1\|23477_24053_+	TerD family protein	K4JRX3	Caulobacter_phage	8.7e-31	40.8
WP_045295110.1\|24112_24763_+	hypothetical protein	NA	NA	NA	NA
WP_045337318.1\|24779_26033_+	tellurium resistance protein TerF	NA	NA	NA	NA
WP_158409080.1\|26494_26662_-	hypothetical protein	NA	NA	NA	NA
WP_045337317.1\|26648_26993_-	hypothetical protein	NA	NA	NA	NA
WP_045295106.1\|26983_28087_-	hypothetical protein	NA	NA	NA	NA
WP_000019445.1\|28263_29244_+\|transposase	IS5-like element ISKpn26 family transposase	A0A077SK28	Escherichia_phage	1.0e-185	99.4
WP_088728396.1\|29301_29493_+	hypothetical protein	NA	NA	NA	NA
WP_004118209.1\|30052_30316_-\|transposase	transposase	NA	NA	NA	NA
WP_001295708.1\|30330_30594_+	hypothetical protein	NA	NA	NA	NA
WP_084833193.1\|30835_31117_+	helix-turn-helix domain-containing protein	A0A1B1IUF9	uncultured_Mediterranean_phage	5.2e-05	38.2
WP_004118809.1\|31151_31721_+	small heat shock protein sHSP20	NA	NA	NA	NA
WP_045337276.1\|31826_34676_+	heat shock survival AAA family ATPase ClpK	K4FB40	Cronobacter_phage	2.6e-128	41.1
WP_017146640.1\|34675_34867_+	hypothetical protein	NA	NA	NA	NA
WP_023205099.1\|35614_35755_+\|protease	ATP-dependent metalloprotease FtsH	NA	NA	NA	NA
WP_001275372.1\|35842_36301_+	small heat shock protein sHSP20-GI	NA	NA	NA	NA
WP_023326112.1\|36323_37238_+	heat resistance protein YfdX1	NA	NA	NA	NA
WP_004118195.1\|37340_38228_+	heat resistance protein YfdX2	NA	NA	NA	NA
WP_001090779.1\|38317_38929_+	heat resistance membrane protein HdeD-GI	NA	NA	NA	NA
WP_023326111.1\|39008_40154_+	hypothetical protein	NA	NA	NA	NA
WP_000786816.1\|40143_40584_+	heat resistance system thioredoxin Trx-GI	A0A023NHA9	Dinoroseobacter_phage	2.6e-11	34.7
WP_023326110.1\|40587_42297_+	heat resistance system K+/H+ antiporter KefB-GI	NA	NA	NA	NA
WP_001514138.1\|42299_42797_+	heat resistance protein PsiE-GI	NA	NA	NA	NA
WP_084833187.1\|42774_43722_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_032629948.1\|43746_44898_+\|protease	trypsin-like serine protease	A0A1B1IT49	uncultured_Mediterranean_phage	7.5e-26	30.3
WP_045337267.1\|45742_46738_+\|transposase	IS110 family transposase	A0A1S7J231	Thermus_phage	1.4e-20	28.6
WP_000019445.1\|47056_48037_-\|transposase	IS5-like element ISKpn26 family transposase	A0A077SK28	Escherichia_phage	1.0e-185	99.4
WP_013087269.1\|51553_52039_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_007869691.1\|52026_52293_-	DUF1778 domain-containing protein	NA	NA	NA	NA
WP_059359379.1\|52945_53959_+	replication initiation protein	NA	NA	NA	NA
WP_008502220.1\|54807_55041_+	DUF2767 family protein	NA	NA	NA	NA
WP_008502221.1\|55062_55830_-	conjugal transfer protein TraX	NA	NA	NA	NA
WP_008502222.1\|56163_56406_-	hypothetical protein	NA	NA	NA	NA
WP_045355004.1\|56837_57788_+	hypothetical protein	NA	NA	NA	NA
WP_000019445.1\|58086_59067_-\|transposase	IS5-like element ISKpn26 family transposase	A0A077SK28	Escherichia_phage	1.0e-185	99.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP019839

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019839_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019839_1

3288613-3289242

Orphan

I-F

Consensus_repeat	Method
TTTCTAAGCTGCCTGTACGGCAGTGAAC	PILER-CR
TTTCTAAGCTGCCTGTACGGCAGTGAAC	CRISPRCasFinder
TTTCTAAGCTGCCTGTACGGCAGTGAAC	CRT

10 spacers

The CRISPR arrays of NZ_CP019839_1

>merge|NZ_CP019839|1|3288613-3289242|PILER-CR,CRISPRCasFinder,CRT
TTTCTAAGCTGCCTGTACGACAGTGAACTAGTCGGCCTTCTTTTGGCGGCAAGCCACAGATTTCTAAGCTGCCTGTACGGCAGTGAACGCTCGTCACCAGGGTTAACTGATTTGTCGGAATTTTCTAAGCTGCCTGTACGGCAGTGAACTTACCGTTTCAAAGTGGAATACTGCAGGACGTTTTCTAAGCTGCCTGTACGGCAGTGGACAGGAGGAACTTATGGCAATTTTAGTGGAAGCTTTTCTAAGCTGCCTGTACGGCATTGAACGGCAATGGTCCGGACGGTCGCCCTGAATTCCATTTCTAAGCTGCCTGTACGGCAGTGAACTTAGGTGGCGGGGTGATGGAGGATGTGTCGGTTTTCTAAGCTGCCTGTACGGCAGTGAACGTGGATGGTCCTCGCGCCCTCTGGTGTTGTTTTTTTCTAAGCTGCCTGTACGGCAGTGAACGGGTAATACCCATCAAAGGGGCGAGCACGTATTTTCTAAGCTGCCTGTACGGCAGTGAACAAGGCATTCAAAAGCCTGTAAGGGGACGTTATTTTCTAAGCTGCCTGTACGGCAGTGAACGCAAGGGATGGCAAAAGTGATGGCGTCGTTCGTTTCTAAGCTGCCTGTACGGCAGTGAAC

>NZ_CP019839|1|1|3288613-3289242|PILER-CR
TTTCTAAGCTGCCTGTACGACAGTGAAC	TAGTCGGCCTTCTTTTGGCGGCAAGCCACAGA
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GCTCGTCACCAGGGTTAACTGATTTGTCGGAAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	TTACCGTTTCAAAGTGGAATACTGCAGGACGT
TTTCTAAGCTGCCTGTACGGCAGTGGAC	AGGAGGAACTTATGGCAATTTTAGTGGAAGCTTTT
CTAAGCTGCCTGTACGGCATTGAACGGC	AATGGTCCGGACGGTCGCCCTGAATTCCATTT
CTAAGCTGCCTGTACGGCAGTGAACTTA	GGTGGCGGGGTGATGGAGGATGTGTCGGTTTT
CTAAGCTGCCTGTACGGCAGTGAACGTG	GATGGTCCTCGCGCCCTCTGGTGTTGTTTTTTT
CTAAGCTGCCTGTACGGCAGTGAACGGG	TAATACCCATCAAAGGGGCGAGCACGTATTTT
CTAAGCTGCCTGTACGGCAGTGAACAAG	GCATTCAAAAGCCTGTAAGGGGACGTTATTTT
CTAAGCTGCCTGTACGGCAGTGAACGCA	AGGGATGGCAAAAGTGATGGCGTCGTTCGTTT
CTAAGCTGCCTGTACGGCAGTGAAC

>NZ_CP019839|1|1|3288613-3289242|CRISPRCasFinder
TTTCTAAGCTGCCTGTACGACAGTGAAC	TAGTCGGCCTTCTTTTGGCGGCAAGCCACAGA
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GCTCGTCACCAGGGTTAACTGATTTGTCGGAAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	TTACCGTTTCAAAGTGGAATACTGCAGGACGT
TTTCTAAGCTGCCTGTACGGCAGTGGAC	AGGAGGAACTTATGGCAATTTTAGTGGAAGCT
TTTCTAAGCTGCCTGTACGGCATTGAAC	GGCAATGGTCCGGACGGTCGCCCTGAATTCCA
TTTCTAAGCTGCCTGTACGGCAGTGAAC	TTAGGTGGCGGGGTGATGGAGGATGTGTCGGT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GTGGATGGTCCTCGCGCCCTCTGGTGTTGTTTT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GGGTAATACCCATCAAAGGGGCGAGCACGTAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	AAGGCATTCAAAAGCCTGTAAGGGGACGTTAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GCAAGGGATGGCAAAAGTGATGGCGTCGTTCG
TTTCTAAGCTGCCTGTACGGCAGTGAAC

>NZ_CP019839|1|1|3288613-3289242|CRT
TTTCTAAGCTGCCTGTACGACAGTGAAC	TAGTCGGCCTTCTTTTGGCGGCAAGCCACAGA
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GCTCGTCACCAGGGTTAACTGATTTGTCGGAAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	TTACCGTTTCAAAGTGGAATACTGCAGGACGT
TTTCTAAGCTGCCTGTACGGCAGTGGAC	AGGAGGAACTTATGGCAATTTTAGTGGAAGCT
TTTCTAAGCTGCCTGTACGGCATTGAAC	GGCAATGGTCCGGACGGTCGCCCTGAATTCCA
TTTCTAAGCTGCCTGTACGGCAGTGAAC	TTAGGTGGCGGGGTGATGGAGGATGTGTCGGT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GTGGATGGTCCTCGCGCCCTCTGGTGTTGTTTT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GGGTAATACCCATCAAAGGGGCGAGCACGTAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	AAGGCATTCAAAAGCCTGTAAGGGGACGTTAT
TTTCTAAGCTGCCTGTACGGCAGTGAAC	GCAAGGGATGGCAAAAGTGATGGCGTCGTTCG
TTTCTAAGCTGCCTGTACGGCAGTGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019839.1\|WP_021240893.1\|3281975_3283634_-\|ATP-dependent-endonuclease	unknown	unknown	gnl\|CDD\|226121
NZ_CP019839.1\|WP_023343670.1\|3289993_3291712_+\|ubiquinone-dependent-pyruvate-dehydrogenase	unknown	unknown	gnl\|CDD\|181661
NZ_CP019839.1\|WP_063418446.1\|3283924_3284620_+\|aquaporin-Z	unknown	unknown	gnl\|CDD\|235453
NZ_CP019839.1\|WP_063418203.1\|3300967_3301765_-\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|224900
NZ_CP019839.1\|WP_008499994.1\|3277810_3279751_-\|macrolide-ABC-transporter-ATP-binding-protein/permease-MacB	unknown	unknown	gnl\|CDD\|182528
NZ_CP019839.1\|WP_063418445.1\|3297998_3300710_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|119365
NZ_CP019839.1\|WP_039266063.1\|3289407_3289842_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|311556
NZ_CP019839.1\|WP_021240900.1\|3291750_3292752_+\|low-specificity-L-threonine-aldolase	unknown	unknown	gnl\|CDD\|236710
NZ_CP019839.1\|WP_008500006.1\|3294291_3295305_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NZ_CP019839.1\|WP_049122658.1\|3285834_3287487_+\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|235391
NZ_CP019839.1\|WP_008499993.1\|3277518_3277740_+\|cold-shock-like-protein-CspD	unknown	unknown	gnl\|CDD\|184960
NZ_CP019839.1\|WP_023292896.1\|3281022_3281979_+\|DUF535-domain-containing-protein	unknown	unknown	gnl\|CDD\|377343
NZ_CP019839.1\|WP_023327007.1\|3279747_3280863_-\|macrolide-transporter-subunit-MacA	unknown	unknown	gnl\|CDD\|183211
NZ_CP019839.1\|WP_006174393.1\|3276930_3277251_-\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP019839.1\|WP_063418443.1\|3292762_3294199_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187556
NZ_CP019839.1\|WP_008500008.1\|3297427_3297862_-\|type-III-secretion-system-invasion-protein-IagB	unknown	unknown	gnl\|CDD\|185228
NZ_CP019839.1\|WP_063418442.1\|3287497_3288466_+\|NADH-oxidoreductase	unknown	unknown	gnl\|CDD\|236735
NZ_CP019839.1\|WP_063418444.1\|3295465_3297277_-\|chitinase	unknown	unknown	gnl\|CDD\|381595
NZ_CP019839.1\|WP_063418202.1\|3301761_3302247_-\|type-II-secretion-system-protein-M	unknown	unknown	gnl\|CDD\|377391
NZ_CP019839.1\|WP_063418441.1\|3284790_3285690_+\|lysine-exporter-LysO-family-protein	unknown	unknown	gnl\|CDD\|225287

Protein	Function_ID	Function_description	E-value
NZ_CP019839.1\|WP_021240893.1\|3281975_3283634_-\|ATP-dependent-endonuclease	gnl\|CDD\|226121	COG3593, COG3593, Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair].	0
NZ_CP019839.1\|WP_023343670.1\|3289993_3291712_+\|ubiquinone-dependent-pyruvate-dehydrogenase	gnl\|CDD\|181661	PRK09124, PRK09124, ubiquinone-dependent pyruvate dehydrogenase.	0
NZ_CP019839.1\|WP_063418446.1\|3283924_3284620_+\|aquaporin-Z	gnl\|CDD\|235453	PRK05420, PRK05420, aquaporin Z; Provisional.	1.98843e-146
NZ_CP019839.1\|WP_063418203.1\|3300967_3301765_-\|prepilin-peptidase	gnl\|CDD\|224900	COG1989, PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	7.7292e-43
NZ_CP019839.1\|WP_008499994.1\|3277810_3279751_-\|macrolide-ABC-transporter-ATP-binding-protein/permease-MacB	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	0
NZ_CP019839.1\|WP_063418445.1\|3297998_3300710_-\|glycoside-hydrolase	gnl\|CDD\|119365	cd06548, GH18_chitinase, The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.	8.46689e-126
NZ_CP019839.1\|WP_039266063.1\|3289407_3289842_-\|DoxX-family-protein	gnl\|CDD\|311556	pfam07681, DoxX, DoxX. These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.	5.05523e-12
NZ_CP019839.1\|WP_021240900.1\|3291750_3292752_+\|low-specificity-L-threonine-aldolase	gnl\|CDD\|236710	PRK10534, PRK10534, L-threonine aldolase; Provisional.	0
NZ_CP019839.1\|WP_008500006.1\|3294291_3295305_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	6.20693e-53
NZ_CP019839.1\|WP_049122658.1\|3285834_3287487_+\|hydroxylamine-reductase	gnl\|CDD\|235391	PRK05290, PRK05290, hybrid cluster protein; Provisional.	0
NZ_CP019839.1\|WP_008499993.1\|3277518_3277740_+\|cold-shock-like-protein-CspD	gnl\|CDD\|184960	PRK14998, PRK14998, cold shock-like protein CspD; Provisional.	6.50125e-48
NZ_CP019839.1\|WP_023292896.1\|3281022_3281979_+\|DUF535-domain-containing-protein	gnl\|CDD\|377343	pfam04393, DUF535, Protein of unknown function (DUF535). Family member Shigella flexneri VirK is a virulence protein required for the expression, or correct membrane localization of IcsA (VirG) on the bacterial cell surface,. This family also includes Pasteurella haemolytica lapB, which is thought to be membrane-associated.	1.68223e-121
NZ_CP019839.1\|WP_023327007.1\|3279747_3280863_-\|macrolide-transporter-subunit-MacA	gnl\|CDD\|183211	PRK11578, PRK11578, macrolide transporter subunit MacA; Provisional.	0
NZ_CP019839.1\|WP_006174393.1\|3276930_3277251_-\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	9.90991e-48
NZ_CP019839.1\|WP_063418443.1\|3292762_3294199_+\|SDR-family-oxidoreductase	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.71043e-141
NZ_CP019839.1\|WP_008500008.1\|3297427_3297862_-\|type-III-secretion-system-invasion-protein-IagB	gnl\|CDD\|185228	PRK15328, PRK15328, type III secretion system invasion protein IagB.	2.16696e-85
NZ_CP019839.1\|WP_063418442.1\|3287497_3288466_+\|NADH-oxidoreductase	gnl\|CDD\|236735	PRK10684, PRK10684, HCP oxidoreductase, NADH-dependent; Provisional.	0
NZ_CP019839.1\|WP_063418444.1\|3295465_3297277_-\|chitinase	gnl\|CDD\|381595	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Glycoside hydrolase family 19 chitinases are found primarily in plants (classes I, III, and IV), but some are found in bacteria. Class I and II chitinases are similar in their catalytic domains. Class I chitinases have an N-terminal cysteine-rich, chitin-binding domain which is separated from the catalytic domain by a proline and glycine-rich hinge region. Class II chitinases lack both the chitin-binding domain and the hinge region. Class IV chitinases are similar to class I chitinases, but they are smaller in size due to certain deletions. Despite lacking any significant sequence homology with lysozymes, structural analysis reveals that family 19 chitinases, together with family 46 chitosanases, are similar to several lysozymes including those from T4-phage and from goose. The structures reveal that the different enzyme groups arose from a common ancestor glycohydrolase antecedent to the prokaryotic/eukaryotic divergence.	7.86767e-71
NZ_CP019839.1\|WP_063418202.1\|3301761_3302247_-\|type-II-secretion-system-protein-M	gnl\|CDD\|377391	pfam04612, T2SSM, Type II secretion system (T2SS), protein M. This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers.	1.97236e-28
NZ_CP019839.1\|WP_063418441.1\|3284790_3285690_+\|lysine-exporter-LysO-family-protein	gnl\|CDD\|225287	COG2431, COG2431, Predicted membrane protein [Function unknown].	8.43683e-114

>NZ_CP019839.1|WP_063418442.1|3287497_3288466_+|NADH-oxidoreductase
MTMPTSQCPWRMQVHHIHQETPDVWTLSLLCHDYYPYRAGQYALVSVRHSADTLRAYTLSSTPGVSEYITLTVRRIDDGAGSQWLTRDVKRGDYIWLSDAQGDFTCDDKADDKFLLLAAGCGVTPIMSMRRWLAKNRPQADVQVIFSVRSPDDVIFAEEWRDYPVTLVAEHNATHGFVPGRLSRELLQSVPDIANRTVMTCGPAPYMAIVEEEVKALGVTRFFKEQFFTPVAEAATSGIQFTKLQPAQTFFGRVGTTLLEALESNNVPVAAACRAGVCGCCKTKVVSGEYTVTSTMTLSDAEIAEGYVLACSCHPQGDLVLA
>NZ_CP019839.1|WP_049122658.1|3285834_3287487_+|hydroxylamine-reductase
MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWACKAREYGIVDHYVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCMKADANARVENPMSDLQLVSDDLGDLQRQAAEFTPNKDKAAIGDNILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFRVMSILDAGETGTYGHPTPTQVNVKATEGKCILISGHDLKDLYNLLKQTEGTGVNVYTHGEMLPAHGYPELRKFKHLIGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVSHLEGDDFGPVIAQAQQMAGFPYSEIPHLITVGFGRETLLGAADSLIDLVSREKLRHIFLVGGCDGARGERNYFTDFATRVPEDCLILTLACGKYRFNKLDFGNIEGLPRLIDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVTNIVTGPTAPGFLTPDLLAVLNEKFGLRSVTNVEDDMKQLLSA
>NZ_CP019839.1|WP_063418441.1|3284790_3285690_+|lysine-exporter-LysO-family-protein
MFSGLLIILLPLIAGYLIPLHRESALRLINRFLSWIVYVILFFMGISLAFLDNLATNLLSILHYSVVTVVVILLCNIAALFWLERTVPWKNHHHQEKLPSRIAMALESLKLCGVVVLGFLLGLTGWAFLQHATEASEYTLIFLLFLIGIQLRNNGMTLKQIVLNRRGMMVAVIVISSSMVAGVINAFILDLPLKTGLAMASGFGWYSLSGILLTESFGPVIGSAAFFNDLARELLAIMLIPGLVRRSRSTALGLCGATSMDFTLPVLQRSGGLEMVPAAIVHGFILSLLVPVLMAVFSA
>NZ_CP019839.1|WP_063418446.1|3283924_3284620_+|aquaporin-Z
MFRKLAAECFGTFWLVFGGCGSAVLAAAFPELGIGFVGVALAFGLTVLTMAFAVGHISGGHFNPAVTLGLWAGGRFPAKEVIGYIVAQVVGGIIAAGVLYVIASGKAGFDAAASGFASNGFGEHSPGGYSMLSAIVIEIVLTAGFLLVIHGATDKQAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGGWALEQLWLFWVMPIIGGILGGVLYRTLLEKRD
>NZ_CP019839.1|WP_021240893.1|3281975_3283634_-|ATP-dependent-endonuclease
MLLERVEIVGFRGINRLSLQLEQNNVLIGENAWGKSSLLDALTLLLSPEDDLYHFVRDDFWFPPGDVTGREKHLHIILTFRESEPGRHRVRRFRPLSPCWVPCDDGFHRIFYRLEGEMAENEGVLTLRDFLDEKASPIPLDNIDDLARHLIRLTPVLRLRDARFMRRIRNGTVPNMPEVEVTARELDFLARELVSRPQNLTDGQIRQGLSAMVQLLEHYFSEQGTSESRHRLMRRRSHDEQRSWRYLDIINRMIDRPGGRTHRVILLGLFSTLLQAKGTVRLDRDARPLLLVEDPETRLHPIMLSVAWHLLNLLPLQRVTTTNSGELLSLTPVEHVCRLVRESSRVSAFRLGPGGLNAEDGRRIAFHIRFNRASSLFARCWLLVEGETETWVINELARQCGHHFDAEGIKVIEFAQSGLKPLIKFARRMGIEWHVLVDGDEAGKKYASTVRSLLNNEREEERDHLTMLPAMDMEHFMYRQGFDDVFHRIAMVPVDVPMNMRRVIAKAIHRSSKPDLAIEVATEAGRRGVEAVPTLLRKMFSRVLWLARGRAD
>NZ_CP019839.1|WP_023292896.1|3281022_3281979_+|DUF535-domain-containing-protein
MSSIVDTPFSNLPQPASGWQLFSHLASGKLTPGLAWQNPAYRRKFMLRSLATPVSTARLLTSLAKQPSLMQMLQVQPGLPCRLHRPWLTVNMDRQQALESLNWHYQTMSRHMPASLLSGYLSKKGFTLLTLTGKDEEQFTVRLCADAFLDKEGEATLAFCDHQNTVLAEMTFTLCQLEGKSTLFIGGLQGAKAHVPHELIQGATKACHGLFPKRLLVEAAMTLGTAFPVEQIVAVSNDTHIYRSWRYRKKKEGKLLADYDSFWISIGGEKQDSGNFMLPLVMPRKPMEEIASKKRSEYRRRYALLDSLIQQVNQATQR
>NZ_CP019839.1|WP_023327007.1|3279747_3280863_-|macrolide-transporter-subunit-MacA
MNLKGKRRTLFLLLAVVVLAGGYWLWQVLNAPVPQYQTLIVRPGELQQNVLATGKLDALRKVDVGAQVSGQLKTLSVEIGDKVKKGQLLGVIDPEQAENQIREVEATLMELRAQRAQAQAERNLAQVTLTRQQALAKTQAISKQDLDTATTELAVKQAQIGTIDAQIKRNQASLDTAKTNLDYTKIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLRPGQNAWFTVLGDPQTRYEGVLKDILPTPEKVNDAIFYYARFEVPNPQGVLRLDMTAQVHIQLTGVKNVLTIPLSALGESAGDSRYKVKVLRNGETREREVVIGARNDTDVVVVKGLEEGEEVVISESLPGAAK
>NZ_CP019839.1|WP_008499994.1|3277810_3279751_-|macrolide-ABC-transporter-ATP-binding-protein/permease-MacB
MTALLELKDIRRSYPSGDGPVEVLKGISLRVEAGEMVAIVGASGSGKSTLMNILGCLDKPTSGTYRVAGTDVSTLDGDALAKLRREHFGFIFQRYHLLSHLNAAQNVEVPAVYAGVERKKRLERAQMLLTRLGLAERVEYQPSQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSGEEVMAILHQLRDQGHTVIIVTHDPQVAAQAERIIEIHDGELVSNPPPRESRAAAPKEVLPASTGWGQFSSGFREALTMAWLAMAANKMRTLLTMLGIIIGIASVVSIVVVGDAAKQLVLADIRAIGTNTIDVYPGKDFGDDEPQYQQALKYDDLAAIQKQPWVNSATPAVSQNLRLRVGNVDVAASANGVSGDYFNVYGMTFSEGATFNAEQLAGRAQVVVLDANSRRQLFPNKANVVGEVILVGNMPATVIGVAEEKQSMFGSSKILRVWLPYTTISGRIMGQSWLNSITVRVKEGYDSAMAEQQLERLLTLRHGKKDFFTWNMDGLLKTAEKTTRTLQLFLTLVAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARASDVLQQFLIEAVLVCLVGGAMGIALSMMIAFALQLFLPGWEIGFSPVAIITAFLCSTFTGILFGWLPARNAARLDPVDALARE
>NZ_CP019839.1|WP_008499993.1|3277518_3277740_+|cold-shock-like-protein-CspD
MEMGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVRFDVHQGPKGNHASLIVPIEAETVA
>NZ_CP019839.1|WP_006174393.1|3276930_3277251_-|ATP-dependent-Clp-protease-adapter-ClpS
MGKTNDWLDFDQLAEDKVRDALKPPSMYKVMLMNDDYTPMEFVIDVLQKFFSYDVERATQLMLTVHYRGKAICGIFTAEVAETKVAMVNDYARENEHPLLCTLEKA
>NZ_CP019839.1|WP_039266063.1|3289407_3289842_-|DoxX-family-protein
MVKSLLIAVNEKLSCDDLGKLLLRLAVGGLMLFHGLHKLFGGVGFISGMLVEKGLPGFIAYGVLIGEVVAPILIIVGLFTRPAALVLAFTMIVAWLMVGLDETFALDKVGAWAIESLVYFFIGSLAVAFLGAGRFALGKTPAWR
>NZ_CP019839.1|WP_023343670.1|3289993_3291712_+|ubiquinone-dependent-pyruvate-dehydrogenase
MKQTVAAYIAKTLEQAGVKRIWGVTGDSLNGLSDSLNKMKTIEWMPTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVIPGDVALKAAPEGASTHWYHAPQPVVTPAEEELKKLAQLLRYASNIALMCGSGCAGAHKELLEFAGKLKAPIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLILLGTQFPYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLAALLPLLEEKTDRKFLDKALSDYRDARKGLDDLAKPSDKAIHPQYLAQQISHFADDDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAKATAPERQVVAMCGDGGFSMLMGDFLSVVQMKLPLKIVVFNNSVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKLEQAKGFSLYMLRAIISGRGDEVIELAKTNWLR
>NZ_CP019839.1|WP_021240900.1|3291750_3292752_+|low-specificity-L-threonine-aldolase
MIDLRSDTVTRPSRAMLEEMMAAPVGDDVYGDDPTVNELQRYAAELSGKEAALFLPTGTQANLVALLSHCERGEEYIVGQGAHNYLYEAGGAAVLGSIQPQPIDAAPDGTLPLDKVAAKIKADDIHFARTRLLSLENTHNGKVLPREYLKAAWEFTRERGLGLHVDGARIFNAVVEYGCALKEITQYCDSFTICLSKGLGTPVGSLLVGNADYIKRANRWRKMTGGGMRQAGILAAAGLYALKNNVARLKDDHDNAAWMAAQLREIGADVMRHDTNMLFVRVGDDHAAALGEFMKARGVLINASPVVRLVMHLDVNREQLADVVKHWQAFLQR
>NZ_CP019839.1|WP_063418443.1|3292762_3294199_+|SDR-family-oxidoreductase
MPQRILVLGASGYIGQHLTAALSQQGHQVLAAARNTERLQKLGLPGVTCHNVDLNWPKALPALLEGVDTLYYLVHSMGEGGDFIAHERQVAMNVRDALLQTPVKQVIFLSSLQAPEREQSDHLRARQLTADILRGANIPVTELRAGIIVGAGSAAFEVMRDMVYNLPVLTPPRWVRSRTTPIALENLLHYLVALLDHPAEQHRVLEAAGPEVLSYQAQFEHFMRVSGRRRWLIPIPFPTRWISVWFLNVITSVPPTTAKALIQGLKHDLLADDRALRALIPQDLIRFDDAVRNTLKEEEQLVNSSDWGYDAQAFARWRPEYGYYPKQAGCTVKTSASLAALWEVVNQIGGKERYFFGNLLWQTRGAMDLLVGHRLAKGRPARPYLEVGDAVDSWKVIIVEPEKQLALLFGMKAPGLGRLCFTLKDKGDHRELDVRAWWHPHGMPGLFYWLLMIPAHLFIFRGMAKRIAQRAEQKTEKI
>NZ_CP019839.1|WP_008500006.1|3294291_3295305_+|NAD(P)-dependent-oxidoreductase
MKVLVTGATSGLGRNAVEFLRNKGISVRATGRNEAMGKLLQKMGAEFVHADLTELVSSQAKVMLAGIDTLWHCSSFTSPWGTQEAFDLANVRATRRLGEWAVAWGVRNFIHISSPSLYFDYHHHRDVQEDFRPARFACEFARSKAASEEVIDLLAQSNPHTRFTVLRPQSLFGPHDKVFIPRLAQMMHHYGSVLLPRGGDALVDMTYYENAVHAMWLASQPDCDKLISGRAYNITNGEPCTLRSIVQRLIDELQINCRIRSVPYPMLDMIARSMERFGSKTAKEPALTHYGVSKLNFDFTLDISRAENELGYKPVVTLDEGIMRTAAWLRDHGKLHR
>NZ_CP019839.1|WP_063418444.1|3295465_3297277_-|chitinase
MTKRTLLSVLVAGACIAPFMAQAASLQAASSEPYTMKASDLAKKEKELTNFPLMVSVKDTIATLDNSLVEQIEPGRASNPDNVKRVEGIVKASDWEYLFPLRAQSYTYSNFLKAVGKFPALCKTYNDGRDSDAICRKELATMFAHFAQETGGHESWRPEAEWRQALVHVREMGWTEGQKGGYNGECNPDIWQGQTWPCGKDKDGDFVSYFGRGAKQLSYNYNYGPFSEAMFGTVRTLLDKPELVADTWLNLASAIFFFAYPQPPKPSMLQVIDGTWQPNDHDKANGLVPGFGVTTQIINGGVECGGPTEIAQSENRIKYYKEFANYLKVPVPANEVLGCANMKQFDEGGAGALKIYWEQDWGWSPDTPDGKTYSCQLVGYQTPFSAFKEGDYTNCVKKFYNVNIINDDGSAVTPGEDKTPADTTPPADTMPAEDTTPVEPATVNHAPVAQIAGPIGAVEAGAQVSLSAEGSTDADGNKLTYTWRSQDGQTVTGQDKAVVTFKAPESATAQQYEIGLTVSDGELTSTTSYLLNVKAKAESKDEGTSGSYAAWSANSKYNAGDIVNNHGKLFQCKPFPYSGWCNNAPAYYEPGAGLAWADAWTAL
>NZ_CP019839.1|WP_008500008.1|3297427_3297862_-|type-III-secretion-system-invasion-protein-IagB
MKRVIIFLLLFSQSVFANCWDNAGHYYHVDPWLLYAIAKVESGMNPHAVGWNHDGTRDVGLMQINSSHFSELERQGIDENQLINEPCTSIMVGASILSGMINVYGYNWEAVGAYNAGLKKENYPQRMRYAHKVWAKYQQIKSGK
>NZ_CP019839.1|WP_063418445.1|3297998_3300710_-|glycoside-hydrolase
MKFIKPKYLALFIAAATGSAFAAAPGAPTIASGNDKFALVEVDQAAQDYNSLVKVHNDGVDVKVEWNVWSGDAPTSAKVLLDGKTVWTGAAGASGSATFKVKKGGRYQEQVEVCNASGCTKSASKLIIVADTDGSHLLPLNAPLQENNKTFAKHTDKVVAAYFPEWGVYDRNFPVDKIPAANLNHILYGFIPICGGDGINDGLKTVEGGNSFSVLQRDCAGRPDYTVAIHDPWAALQKPQSGVSNWDDPYKGNFGQLMALKKAHPDLKVLPSIGGWTLSDPFFHMGDPAIRARFVSSVKDFLQTWKFFDGVDIDWEFPGGGGVSEHLGNPQQDKATYTALMHDLRTMLNELSAQTGRTYELTSAIGAGRDKIEDVDYTAAQQYLDHIFLMSYDFYGGWSNTELGHQAALRAPSWRPDTNYTTENGVDALLAQGVQPGKIVVGAGMYGRGWTGVHGYTGDNPFTGTATGMVKGTWEPGVVDYRQIVNEYKGKPGWEYGYDANAEAPYVFNKSTGDLITYEDARSTAAKGKYVLSKNLGGLFAWSIDSDTGDILNAMNESLLGGSTPVDPVVTNHAPIASSADQNVSGPATVTLDGSASSDPDGDAITYKWTQVSGPSVTLSNSTKAKATFNVAAATSDQTMVFRLTVTDAKGLSNAIDVQVVNKAPKANQAPVVNAMEAVTLQAGETYALHAQAVDPDGDAMTFSWSVPADMHATGTDTANVTITAPDVATTSTYTLSVVVGDGKTSVQSNVQVTVNPKPADVTPPSDDVTPPSDEVTPPSDDVTPPSDEGSATGSCDAPVDANASKYAAWDGSKIYNSGDTVSFDHLVWKAKYWTQGNQPGFGVDAWELVSNVKMNWRSDLVYNGGETTTYQGNVYRAKWWTRGDNPANSDVWVKEGPSTDCK
>NZ_CP019839.1|WP_063418203.1|3300967_3301765_-|prepilin-peptidase
MNGLILVRESYPVGFAAMSGVFGAILGSFLGVVVDRVPGMVLEEESRSNLLFPASHCPVCQHALRAWENIPLLSWLALRGRCRCCKSPIPLRLFLLELLTAVFFGLTARWIPDLASLFSLWVLAAFLLPLAMIDGQHQLLPDCLTQPLLWAGLLFHAFSHGLPLRDALLGAVAGYLSLWLVYWAFRLLTRREGLGYGDFKLLAALGAWCGWQSLPAIELIAALSGIVGYLLLNKSNKNNLTIAFGPYLAFAGIALYTYQLFVNTY
>NZ_CP019839.1|WP_063418202.1|3301761_3302247_-|type-II-secretion-system-protein-M
MKARIAQFTSRYQQYSAREKFILKIAAGALCSAVIYYAGIIPLDNMIKNSQATLARQIETVNWMKTEIDKNHLPVLQVKTDNPRSVVENSAHEINLTLTDIRQDGQTLAFVVNRVNVYKLKNWLREMNLASGVRLEKMNLTPVDHLSDVKAEIQLTWKKVA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019839_1	1.10\|3289186\|32\|NZ_CP019839\|PILER-CR	3289186-3289217	32	KC292029	Halovirus HCTV-1, complete genome	60196-60227	7	0.781
NZ_CP019839_1	1.11\|3288822\|32\|NZ_CP019839\|CRISPRCasFinder,CRT	3288822-3288853	32	NZ_CP015507	Bacillus oceanisediminis 2691 plasmid pBO1, complete sequence	339556-339587	7	0.781
NZ_CP019839_1	1.17\|3289183\|32\|NZ_CP019839\|CRISPRCasFinder,CRT	3289183-3289214	32	KC292029	Halovirus HCTV-1, complete genome	60196-60227	7	0.781
NZ_CP019839_1	1.5\|3288885\|32\|NZ_CP019839\|PILER-CR	3288885-3288916	32	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	1463327-1463358	9	0.719
NZ_CP019839_1	1.5\|3288885\|32\|NZ_CP019839\|PILER-CR	3288885-3288916	32	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	1378036-1378067	9	0.719
NZ_CP019839_1	1.12\|3288882\|32\|NZ_CP019839\|CRISPRCasFinder,CRT	3288882-3288913	32	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	1463327-1463358	9	0.719
NZ_CP019839_1	1.12\|3288882\|32\|NZ_CP019839\|CRISPRCasFinder,CRT	3288882-3288913	32	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	1378036-1378067	9	0.719
NZ_CP019839_1	1.9\|3289126\|32\|NZ_CP019839\|PILER-CR	3289126-3289157	32	NZ_CP033514	Vibrio cholerae strain E4 plasmid pVCR94, complete sequence	50380-50411	10	0.688
NZ_CP019839_1	1.9\|3289126\|32\|NZ_CP019839\|PILER-CR	3289126-3289157	32	NC_023291	Vibrio cholerae strain BI144 plasmid pVCR94deltaX, complete sequence	73513-73544	10	0.688
NZ_CP019839_1	1.16\|3289123\|32\|NZ_CP019839\|CRISPRCasFinder,CRT	3289123-3289154	32	NZ_CP033514	Vibrio cholerae strain E4 plasmid pVCR94, complete sequence	50380-50411	10	0.688
NZ_CP019839_1	1.16\|3289123\|32\|NZ_CP019839\|CRISPRCasFinder,CRT	3289123-3289154	32	NC_023291	Vibrio cholerae strain BI144 plasmid pVCR94deltaX, complete sequence	73513-73544	10	0.688

1. spacer 1.10|3289186|32|NZ_CP019839|PILER-CR matches to KC292029 (Halovirus HCTV-1, complete genome) position: , mismatch: 7, identity: 0.781

--gcaagggatggcaaaagtgatggcgtcgttcg	CRISPR spacer
cgacaacga--ggcgaaagtgatggtgtcgttcg	Protospacer
  .*** *.  ***.**********.********

2. spacer 1.11|3288822|32|NZ_CP019839|CRISPRCasFinder,CRT matches to NZ_CP015507 (Bacillus oceanisediminis 2691 plasmid pBO1, complete sequence) position: , mismatch: 7, identity: 0.781

aggaggaacttatggcaattttagtggaagct---	CRISPR spacer
aggaggcacttatgtcaattttaat---aacttgg	Protospacer
****** ******* ********.*   *.**

3. spacer 1.17|3289183|32|NZ_CP019839|CRISPRCasFinder,CRT matches to KC292029 (Halovirus HCTV-1, complete genome) position: , mismatch: 7, identity: 0.781

--gcaagggatggcaaaagtgatggcgtcgttcg	CRISPR spacer
cgacaacga--ggcgaaagtgatggtgtcgttcg	Protospacer
  .*** *.  ***.**********.********

4. spacer 1.5|3288885|32|NZ_CP019839|PILER-CR matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 9, identity: 0.719

ggcaatggtccggacggtcgccctgaattcca	CRISPR spacer
ggcaatggtccggtcggccgcccatttgctca	Protospacer
************* ***.*****     ..**

5. spacer 1.5|3288885|32|NZ_CP019839|PILER-CR matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 9, identity: 0.719

ggcaatggtccggacggtcgccctgaattcca	CRISPR spacer
ggcaatggtccggtcggccgcccacttgctca	Protospacer
************* ***.*****     ..**

6. spacer 1.12|3288882|32|NZ_CP019839|CRISPRCasFinder,CRT matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 9, identity: 0.719

ggcaatggtccggacggtcgccctgaattcca	CRISPR spacer
ggcaatggtccggtcggccgcccatttgctca	Protospacer
************* ***.*****     ..**

7. spacer 1.12|3288882|32|NZ_CP019839|CRISPRCasFinder,CRT matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 9, identity: 0.719

ggcaatggtccggacggtcgccctgaattcca	CRISPR spacer
ggcaatggtccggtcggccgcccacttgctca	Protospacer
************* ***.*****     ..**

8. spacer 1.9|3289126|32|NZ_CP019839|PILER-CR matches to NZ_CP033514 (Vibrio cholerae strain E4 plasmid pVCR94, complete sequence) position: , mismatch: 10, identity: 0.688

aaggcattcaaaagcctgtaaggggacgttat	CRISPR spacer
gctgttggcaaaagcctggtaggggacgttaa	Protospacer
.  *.   **********  ***********

9. spacer 1.9|3289126|32|NZ_CP019839|PILER-CR matches to NC_023291 (Vibrio cholerae strain BI144 plasmid pVCR94deltaX, complete sequence) position: , mismatch: 10, identity: 0.688

aaggcattcaaaagcctgtaaggggacgttat	CRISPR spacer
gctgttggcaaaagcctggtaggggacgttaa	Protospacer
.  *.   **********  ***********

10. spacer 1.16|3289123|32|NZ_CP019839|CRISPRCasFinder,CRT matches to NZ_CP033514 (Vibrio cholerae strain E4 plasmid pVCR94, complete sequence) position: , mismatch: 10, identity: 0.688

aaggcattcaaaagcctgtaaggggacgttat	CRISPR spacer
gctgttggcaaaagcctggtaggggacgttaa	Protospacer
.  *.   **********  ***********

11. spacer 1.16|3289123|32|NZ_CP019839|CRISPRCasFinder,CRT matches to NC_023291 (Vibrio cholerae strain BI144 plasmid pVCR94deltaX, complete sequence) position: , mismatch: 10, identity: 0.688

aaggcattcaaaagcctgtaaggggacgttat	CRISPR spacer
gctgttggcaaaagcctggtaggggacgttaa	Protospacer
.  *.   **********  ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1649118 : 1658486

Enterobacteria_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023325626.1\|1649118_1650510_+	colanic acid biosynthesis protein WcaM	A0A291LBB9	Klebsiella_phage	1.8e-18	32.3
WP_039266717.1\|1650686_1651580_+	GalU regulator GalF	A0A127AW70	Bacillus_phage	9.0e-43	42.2
WP_063417350.1\|1651965_1653054_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	8.3e-91	48.6
WP_063417351.1\|1653068_1653935_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.4e-109	66.7
WP_074166936.1\|1653956_1654847_+	dTDP-4-dehydrorhamnose reductase	A0A140G5S3	Enterobacteria_phage	5.6e-29	36.3
WP_165602155.1\|1654925_1655852_+	glycosyltransferase	NA	NA	NA	NA
WP_063417352.1\|1655855_1656623_+	ABC transporter permease	NA	NA	NA	NA
WP_063417353.1\|1656622_1657363_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	3.5e-16	30.2
WP_063417354.1\|1657370_1658486_+	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ERI7	Ostreococcus_lucimarinus_virus	2.4e-13	23.5

DBSCAN-SWA_2

1890491 : 1939812

Cronobacter_phage(17.5%)

tail,transposase,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000019445.1\|1890491_1891472_+\|transposase	IS5-like element ISKpn26 family transposase	A0A077SK28	Escherichia_phage	1.0e-185	99.4
WP_084833012.1\|1891510_1892269_-	hypothetical protein	A0A2H4IYC8	uncultured_Caudovirales_phage	9.6e-54	48.4
WP_074166919.1\|1892222_1892510_-	excisionase	A0A2H4J5E1	uncultured_Caudovirales_phage	1.4e-13	43.7
WP_063417242.1\|1892627_1892843_-	hypothetical protein	NA	NA	NA	NA
WP_084833013.1\|1893188_1893470_-	hypothetical protein	NA	NA	NA	NA
WP_131828978.1\|1893629_1893917_-	hypothetical protein	NA	NA	NA	NA
WP_084833015.1\|1893913_1894741_-	chromosome partitioning protein ParB	K7PKM7	Enterobacterial_phage	1.1e-95	67.0
WP_084833016.1\|1895054_1895615_-	siphovirus Gp157 family protein	A0A2I7RAE0	Vibrio_phage	1.5e-11	33.6
WP_084833017.1\|1895611_1897984_-	hypothetical protein	H9C157	Pectobacterium_phage	6.4e-80	53.3
WP_084833018.1\|1897976_1898240_-	hypothetical protein	NA	NA	NA	NA
WP_084833019.1\|1898320_1898668_-	hypothetical protein	NA	NA	NA	NA
WP_084833020.1\|1899076_1899223_-	hypothetical protein	NA	NA	NA	NA
WP_084833021.1\|1899226_1900189_-	hypothetical protein	NA	NA	NA	NA
WP_088728377.1\|1900361_1900769_-	helix-turn-helix domain-containing protein	I6PD69	Cronobacter_phage	1.6e-31	53.7
WP_084833023.1\|1900851_1901085_+	transcriptional regulator	H9C161	Pectobacterium_phage	9.6e-05	34.0
WP_084833024.1\|1901062_1901509_+	hypothetical protein	NA	NA	NA	NA
WP_084833025.1\|1901549_1902359_+	hypothetical protein	A0A1W6JP36	Morganella_phage	3.8e-24	53.3
WP_084833026.1\|1902361_1903087_+	ATP-binding protein	S4TNF5	Salmonella_phage	1.8e-70	58.5
WP_084833182.1\|1903180_1904128_+	GCN5 family acetyltransferase	NA	NA	NA	NA
WP_084833027.1\|1904124_1905030_+	hypothetical protein	NA	NA	NA	NA
WP_084833028.1\|1905505_1905697_+	hypothetical protein	NA	NA	NA	NA
WP_084833029.1\|1905768_1906365_+	DUF1367 family protein	A0A0U2RT94	Escherichia_phage	2.0e-54	55.3
WP_084833030.1\|1906361_1906658_+	hypothetical protein	A0A2H4FS95	Methylophilaceae_phage	1.1e-24	53.7
WP_084833031.1\|1906654_1907311_+	hypothetical protein	A0A1W6JP37	Morganella_phage	4.2e-21	32.9
WP_084833032.1\|1907394_1908495_+	ATP-binding protein	NA	NA	NA	NA
WP_084833033.1\|1908496_1909234_+	DUF4435 domain-containing protein	NA	NA	NA	NA
WP_084833034.1\|1910016_1910826_+	hypothetical protein	NA	NA	NA	NA
WP_165690318.1\|1910889_1911234_+	hypothetical protein	NA	NA	NA	NA
WP_084833036.1\|1911220_1911769_+	glycoside hydrolase family 108 protein	A0A286N2Q6	Klebsiella_phage	6.2e-71	71.3
WP_084833037.1\|1911910_1912372_+	hypothetical protein	NA	NA	NA	NA
WP_165690319.1\|1912491_1912656_-	hypothetical protein	NA	NA	NA	NA
WP_084833038.1\|1912854_1913640_+	ParB N-terminal domain-containing protein	R4TG31	Halovirus	5.3e-47	40.7
WP_084833039.1\|1913632_1914499_+	hypothetical protein	A0A1B1INP7	uncultured_Mediterranean_phage	8.9e-80	53.5
WP_084833040.1\|1914495_1914753_+	hypothetical protein	NA	NA	NA	NA
WP_165690320.1\|1915113_1916130_+\|terminase	terminase small subunit	A0A0U2RXW9	Escherichia_phage	1.7e-53	45.9
WP_063417857.1\|1916098_1917424_+\|terminase	terminase	A0A0N7IRE3	Acinetobacter_phage	8.0e-181	71.1
WP_063417858.1\|1917423_1918812_+	DUF4055 domain-containing protein	A0A1B0VMH0	Pseudomonas_phage	4.0e-130	52.6
WP_063417859.1\|1918813_1919926_+	hypothetical protein	I6PD76	Cronobacter_phage	7.3e-119	57.3
WP_063417860.1\|1919991_1920765_+	hypothetical protein	A0A1B0VMG1	Pseudomonas_phage	4.7e-64	56.2
WP_000019445.1\|1920891_1921872_+\|transposase	IS5-like element ISKpn26 family transposase	A0A077SK28	Escherichia_phage	1.0e-185	99.4
WP_131828980.1\|1921995_1922949_+	Ig domain-containing protein	A0A1B0VMF8	Pseudomonas_phage	2.9e-124	71.7
WP_088728490.1\|1922858_1923227_+	hypothetical protein	NA	NA	NA	NA
WP_063417862.1\|1923266_1923749_+	hypothetical protein	A0A2H5BHE7	Acinetobacter_phage	6.2e-22	45.1
WP_063417863.1\|1923748_1924099_+	hypothetical protein	I6PD77	Cronobacter_phage	6.4e-29	51.7
WP_063417864.1\|1924100_1924682_+	hypothetical protein	G8C7Q1	Escherichia_phage	1.3e-50	54.2
WP_063417865.1\|1924684_1924915_+	hypothetical protein	NA	NA	NA	NA
WP_063417888.1\|1924917_1925328_+	hypothetical protein	A0A2H4J130	uncultured_Caudovirales_phage	2.4e-14	33.8
WP_063417866.1\|1925371_1926310_+	hypothetical protein	I6PBN6	Cronobacter_phage	2.3e-65	47.9
WP_063417867.1\|1926358_1926670_+	hypothetical protein	I6PDG2	Cronobacter_phage	2.7e-31	63.1
WP_063417868.1\|1926717_1926981_+	hypothetical protein	I6PD79	Cronobacter_phage	1.1e-22	67.6
WP_063417869.1\|1926980_1929767_+\|tail	phage tail tape measure protein	E4WL33	Enterobacteria_phage	1.8e-129	37.6
WP_084832855.1\|1929843_1930455_+	outer membrane beta-barrel protein	A0A1B0VBR9	Salmonella_phage	3.2e-23	38.0
WP_063417870.1\|1930511_1930850_+\|tail	phage tail protein	E4WL34	Enterobacteria_phage	7.1e-33	57.1
WP_063417871.1\|1930903_1931641_+\|tail	phage minor tail protein L	M9NYX1	Enterobacteria_phage	4.4e-120	77.6
WP_063417872.1\|1931642_1932377_+	peptidase P60	M9NZD8	Enterobacteria_phage	4.2e-107	73.5
WP_063417873.1\|1932354_1932978_+\|tail	tail assembly protein	K7PH59	Enterobacterial_phage	6.6e-77	71.0
WP_088728491.1\|1933050_1936563_+	DUF1983 domain-containing protein	E4WL39	Enterobacteria_phage	0.0e+00	64.4
WP_063417875.1\|1938082_1938484_+	hypothetical protein	A0A1B0V844	Salmonella_phage	1.1e-13	55.7
WP_063417877.1\|1939193_1939433_+	hypothetical protein	I6PD82	Cronobacter_phage	1.0e-25	67.1
WP_063417878.1\|1939434_1939812_+	hypothetical protein	Q6UAV9	Klebsiella_phage	1.9e-34	55.6

DBSCAN-SWA_3

2638430 : 2648507

Klosneuvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_063418263.1\|2638430_2640464_-	peptidyl-dipeptidase Dcp	A0A1V0SIU1	Klosneuvirus	1.9e-19	22.6
WP_023292548.1\|2640606_2641353_+	bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG	NA	NA	NA	NA
WP_008502405.1\|2641444_2642131_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_063418264.1\|2642166_2642598_-	universal stress protein	A0A1W6JNV4	Morganella_phage	1.8e-17	34.5
WP_014883679.1\|2642885_2643089_+	putative selenium delivery protein YdfZ	J9Q802	Salmonella_phage	3.4e-14	58.2
WP_063418265.1\|2643132_2644596_-	mannitol dehydrogenase family protein	H8ZJP8	Ostreococcus_tauri_virus	2.3e-43	29.1
WP_063418266.1\|2644817_2646185_-	MHS family MFS transporter	NA	NA	NA	NA
WP_084833075.1\|2646258_2647278_-	Zn-dependent oxidoreductase	E3SJ82	Synechococcus_phage	3.7e-16	26.9
WP_023292552.1\|2647292_2648507_-	D-galactonate dehydratase family protein	Q6A202	Oenococcus_phage	8.2e-47	29.4

DBSCAN-SWA_4

2918552 : 2962434

Enterobacterial_phage(38.89%)

integrase,capsid,protease,tail,terminase,holin,head,portal,tRNA

attL 2920423:2920437|attR 2966826:2966840

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_048977349.1\|2918552_2919836_+	YeaH/YhbH family protein	A0A140HLI1	Bacillus_phage	1.3e-10	36.3
WP_084833087.1\|2919963_2920284_-	hypothetical protein	K7PGV5	Enterobacterial_phage	2.7e-50	89.6
WP_045357625.1\|2920283_2920523_-	hypothetical protein	K7P7E2	Enterobacteria_phage	1.3e-36	88.6
2920423:2920437	attL	NA	NA	NA	NA
WP_084833088.1\|2920609_2920876_+	DinI family protein	K7PKM2	Enterobacterial_phage	5.7e-38	93.1
WP_084833089.1\|2920974_2921397_-\|tail	tail fiber assembly protein	B6SCW7	Bacteriophage	4.4e-24	43.1
WP_131828984.1\|2922444_2922813_+	hypothetical protein	NA	NA	NA	NA
WP_084833090.1\|2922777_2923419_-	hypothetical protein	G8C7R6	Escherichia_phage	3.4e-108	86.9
WP_073961575.1\|2923415_2923712_-	hypothetical protein	G8C7R5	Escherichia_phage	1.9e-37	73.5
WP_084833091.1\|2923711_2926885_-	host specificity protein J	O64335	Escherichia_phage	0.0e+00	88.2
WP_000005717.1\|2926938_2927538_-\|tail	tail assembly protein	K7PM97	Enterobacterial_phage	1.1e-79	78.4
WP_024250700.1\|2927592_2927931_-	hypothetical protein	Q6UAW3	Klebsiella_phage	4.0e-20	46.8
WP_084833092.1\|2927954_2928665_-	peptidase P60	Q9MCS0	Enterobacteria_phage	7.2e-144	97.9
WP_045407314.1\|2928666_2929425_-\|tail	phage minor tail protein L	G8C7J7	Escherichia_phage	1.1e-147	99.6
WP_000963855.1\|2929421_2929760_-\|tail	phage tail protein	K7P7R1	Enterobacteria_phage	6.6e-63	100.0
WP_084833093.1\|2929762_2933266_-\|tail	phage tail tape measure protein	K7P7L6	Enterobacteria_phage	0.0e+00	71.3
WP_032665364.1\|2933312_2933648_-	membrane protein	S4TR42	Salmonella_phage	4.0e-52	93.7
WP_006809154.1\|2933703_2933982_-	DUF4035 domain-containing protein	Q9MCS5	Enterobacteria_phage	1.2e-43	97.8
WP_001549114.1\|2933990_2934374_-\|tail	phage tail protein	K7PKV6	Enterobacterial_phage	4.4e-63	93.7
WP_006809155.1\|2934382_2934826_-	hypothetical protein	K7PHL2	Enterobacterial_phage	4.6e-72	93.8
WP_045407322.1\|2934885_2935233_-	DUF3168 domain-containing protein	Q9MCS8	Enterobacteria_phage	2.5e-57	97.4
WP_006809157.1\|2935229_2935679_-	HK97 gp10 family phage protein	K7P6X4	Enterobacteria_phage	2.0e-75	100.0
WP_016042205.1\|2935675_2936014_-\|head	phage head closure protein	K7P7L2	Enterobacteria_phage	2.9e-58	100.0
WP_077883852.1\|2936013_2936340_-	hypothetical protein	K7PGU9	Enterobacterial_phage	3.5e-53	95.4
WP_084833094.1\|2936374_2937532_-\|capsid	phage major capsid protein	Q77WA0	Escherichia_phage	4.2e-210	98.4
WP_047352743.1\|2937534_2938212_-\|head,protease	HK97 family phage prohead protease	K7PKL4	Enterobacterial_phage	7.1e-125	99.6
WP_084833095.1\|2938229_2939504_-\|portal	phage portal protein	Q77W97	Enterobacteria_phage	3.1e-246	99.1
WP_058656708.1\|2939503_2941018_-\|terminase	terminase large subunit	Q9MCV7	Escherichia_phage	6.8e-293	99.6
WP_084833096.1\|2941024_2941510_-\|terminase	terminase	K7PGU7	Enterobacterial_phage	5.9e-81	98.1
WP_084833097.1\|2941693_2941897_-	hypothetical protein	A0A220NRN5	Escherichia_phage	3.4e-22	80.6
WP_084833098.1\|2941896_2942238_-	HNH endonuclease	K7PM05	Enterobacterial_phage	3.0e-63	98.2
WP_084833099.1\|2942234_2942825_-	hypothetical protein	K7P7D2	Enterobacteria_phage	6.9e-108	92.3
WP_084833100.1\|2942806_2944264_-	glycosyltransferase	F1C589	Cronobacter_phage	7.1e-263	88.0
WP_032671404.1\|2944454_2944745_+	lipoprotein bor	C6ZCX3	Enterobacteria_phage	6.3e-30	62.9
WP_047749288.1\|2944855_2945092_-	hypothetical protein	NA	NA	NA	NA
WP_165690327.1\|2945158_2945338_-	hypothetical protein	K7PM01	Enterobacterial_phage	5.2e-19	95.6
WP_084833101.1\|2945288_2945564_-	hypothetical protein	K7PGW4	Enterobacterial_phage	8.6e-13	96.7
WP_084833102.1\|2945571_2946198_-	glycoside hydrolase family 19 protein	K7PJS7	Enterobacterial_phage	1.6e-110	94.2
WP_022648766.1\|2946197_2946479_-\|holin	phage holin family protein	K7PKN9	Enterobacterial_phage	4.1e-42	93.5
WP_016063604.1\|2946465_2946861_-\|holin	holin	K7PHB9	Enterobacterial_phage	6.9e-64	100.0
WP_023293914.1\|2947087_2948371_+	hypothetical protein	NA	NA	NA	NA
WP_023293913.1\|2948388_2948529_+	hypothetical protein	NA	NA	NA	NA
WP_023293912.1\|2948576_2948921_-	hypothetical protein	A0A0P0ZCW0	Stx2-converting_phage	3.1e-52	78.8
WP_084833103.1\|2948935_2949925_-	DUF968 domain-containing protein	K7PJS6	Enterobacterial_phage	2.4e-185	93.9
WP_023293910.1\|2949921_2950647_-	hypothetical protein	G0ZND1	Cronobacter_phage	4.9e-55	53.3
WP_023293909.1\|2950662_2951052_-	RusA family crossover junction endodeoxyribonuclease	K7PKN5	Enterobacterial_phage	1.1e-66	96.0
WP_084833104.1\|2951048_2951369_-	LexA family transcriptional regulator	K7PHB4	Enterobacterial_phage	5.7e-40	75.5
WP_023293907.1\|2951365_2951593_-	hypothetical protein	NA	NA	NA	NA
WP_084833105.1\|2951589_2952249_-	DNA methyltransferase	I6PDF5	Cronobacter_phage	1.9e-98	79.1
WP_084833106.1\|2952248_2952743_-	hypothetical protein	NA	NA	NA	NA
WP_084833107.1\|2952739_2953666_-	transcriptional regulator	K7PLZ7	Enterobacterial_phage	3.9e-73	92.1
WP_071993458.1\|2953622_2953835_-	DUF4222 domain-containing protein	S5M7S5	Escherichia_phage	3.3e-12	63.5
WP_048962196.1\|2954075_2954546_-	hypothetical protein	K7PJS5	Enterobacterial_phage	1.9e-76	95.5
WP_084833108.1\|2954568_2954826_-	helix-turn-helix transcriptional regulator	A0A1C9IHV8	Salmonella_phage	2.4e-25	78.1
WP_047027675.1\|2954923_2955619_+	helix-turn-helix transcriptional regulator	Q8HAA0	Salmonella_phage	1.4e-88	73.0
WP_063417608.1\|2955922_2956423_-	hypothetical protein	A0A192Y7Z0	Salmonella_phage	1.0e-11	28.5
WP_063417643.1\|2956784_2957198_+	hypothetical protein	K7PJS4	Enterobacterial_phage	7.5e-61	89.8
WP_063417607.1\|2957197_2958028_+	hypothetical protein	K7PKM7	Enterobacterial_phage	9.3e-127	89.8
WP_063417606.1\|2958024_2958369_+	hypothetical protein	NA	NA	NA	NA
WP_131828985.1\|2958717_2959599_+	hypothetical protein	I6R0R2	Salmonella_phage	5.2e-27	41.2
WP_063417603.1\|2959595_2959985_+	hypothetical protein	S4TTI6	Salmonella_phage	3.4e-55	81.1
WP_008500733.1\|2960289_2960553_+	hypothetical protein	NA	NA	NA	NA
WP_063417601.1\|2960527_2961670_+\|integrase	tyrosine-type recombinase/integrase	O21929	Phage_21	1.2e-92	48.1
WP_008500735.1\|2961933_2962434_+\|tRNA	YbaK/prolyl-tRNA synthetase associated domain-containing protein	NA	NA	NA	NA
2966826:2966840	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019841

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP019840

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP019839

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection