CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018879	Bacillus megaterium strain JX285 plasmid 6, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP018880	Bacillus megaterium strain JX285 plasmid 7, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP018878	Bacillus megaterium strain JX285 plasmid 5, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP018874	Bacillus megaterium strain JX285 chromosome, complete genome	6 crisprs	DinG,csa3,cas3,WYL,RT,DEDDh	1	3	3	0
NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	2 crisprs	NA	0	2	0	0
NZ_CP018881	Bacillus megaterium strain JX285 plasmid 8, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP018876	Bacillus megaterium strain JX285 plasmid 3, complete sequence	0 crisprs	RT	0	0	0	0
NZ_CP018875	Bacillus megaterium strain JX285 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0	0	0

1. NZ_CP018874

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018874_1

• CRISPR_ID: NZ_CP018874_1
• CRISPR_location: 388783-388942
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018874_1

Consensus_repeat	Method
CAAAATGCTCAAGCATCTAAAAACAACTTCGGTACTGAATTTGGTAGCGAAACAA	CRISPRCasFinder

spacers of NZ_CP018874_1

>1.1|388838|50|NZ_CP018874|CRISPRCasFinder
ATGTACAAGAAGTGAAACAACAAAATGCACAAGCAGCGGCAAACAAAAGC

CRISPR arrays and Neighbor proteins around NZ_CP018874_1

CRISPR arrays

The CRISPR arrays of NZ_CP018874_1

>merge|NZ_CP018874|1|388783-388942|CRISPRCasFinder
CAAAATGCTCAAGCATCTAAAAACAACTTCGGTACTGAATTTGGTAGCGAAACAAATGTACAAGAAGTGAAACAACAAAATGCACAAGCAGCGGCAAACAAAAGCCAAAATGCTCAAGCATCTAAAAACAACTTCGGTACTGAATTTGCTAGCGAAACAA

>NZ_CP018874|1|1|388783-388942|CRISPRCasFinder
CAAAATGCTCAAGCATCTAAAAACAACTTCGGTACTGAATTTGGTAGCGAAACAA	ATGTACAAGAAGTGAAACAACAAAATGCACAAGCAGCGGCAAACAAAAGC
CAAAATGCTCAAGCATCTAAAAACAACTTCGGTACTGAATTTGCTAGCGAAACAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018874.1|WP_013055151.1|381338_382241_-|TIGR01777-family-protein	unknown	unknown	gnl|CDD|273800
NZ_CP018874.1|WP_013055155.1|384565_384721_-|small,-acid-soluble-spore-protein-K	unknown	unknown	gnl|CDD|285399
NZ_CP018874.1|WP_013055165.1|392157_393246_-|aromatic-acid-exporter-family-protein	unknown	unknown	gnl|CDD|226614
NZ_CP018874.1|WP_171843209.1|393569_393743_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013055162.1|389208_389469_+|hypothetical-protein	unknown	unknown	gnl|CDD|372951
NZ_CP018874.1|WP_013055168.1|396386_397178_+|ABC-2-family-transporter-protein	unknown	unknown	gnl|CDD|226953
NZ_CP018874.1|WP_013055152.1|382336_383146_+|recombination-regulator-RecX	unknown	unknown	gnl|CDD|237619
NZ_CP018874.1|WP_013055154.1|384172_384487_+|YfhH-family-protein	unknown	unknown	gnl|CDD|378063
NZ_CP018874.1|WP_078082251.1|397187_397973_+|ABC-2-family-transporter-protein	unknown	unknown	gnl|CDD|226218
NZ_CP018874.1|WP_078081429.1|390370_392122_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP018874.1|WP_013055170.1|398065_398458_+|two-pore-domain-potassium-channel-family-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013055167.1|395380_396394_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213234
NZ_CP018874.1|WP_013055153.1|383436_384090_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187643
NZ_CP018874.1|WP_025752758.1|387538_387763_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013055156.1|384856_385126_+|YfhJ-family-protein	unknown	unknown	gnl|CDD|379438
NZ_CP018874.1|WP_078081427.1|385189_386170_-|metal-dependent-hydrolase	unknown	unknown	gnl|CDD|377294
NZ_CP018874.1|WP_170959598.1|387876_388629_+|enoyl-[acyl-carrier-protein]-reductase-FabL	unknown	unknown	gnl|CDD|236145
NZ_CP018874.1|WP_013055163.1|389664_390201_+|DUF402-domain-containing-protein	unknown	unknown	gnl|CDD|184219
NZ_CP018874.1|WP_078081430.1|393879_395178_-|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl|CDD|183493
NZ_CP018874.1|WP_078081428.1|386409_387504_+|A/G-specific-adenine-glycosylase	unknown	unknown	gnl|CDD|224115

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018874.1|WP_013055151.1|381338_382241_-|TIGR01777-family-protein	gnl|CDD|273800	TIGR01777, Hypothetical_UPF0105_protein_Rv2216/MT2273/Mb2239., TIGR01777 family protein. This model represents a clade of proteins of unknown function including the E. coli yfcH protein. [Hypothetical proteins, Conserved].	1.91118e-139
NZ_CP018874.1|WP_013055155.1|384565_384721_-|small,-acid-soluble-spore-protein-K	gnl|CDD|285399	pfam08176, SspK, Small acid-soluble spore protein K family. This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism. The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination.	2.82664e-17
NZ_CP018874.1|WP_013055165.1|392157_393246_-|aromatic-acid-exporter-family-protein	gnl|CDD|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	6.35009e-68
NZ_CP018874.1|WP_013055168.1|396386_397178_+|ABC-2-family-transporter-protein	gnl|CDD|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	3.15486e-29
NZ_CP018874.1|WP_013055162.1|389208_389469_+|hypothetical-protein	gnl|CDD|372951	pfam14182, YgaB, YgaB-like protein. The YgaB-like protein family includes the B. subtilis YgaB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	1.26565e-19
NZ_CP018874.1|WP_013055152.1|382336_383146_+|recombination-regulator-RecX	gnl|CDD|237619	PRK14135, recX, recombination regulator RecX; Provisional.	2.8941e-120
NZ_CP018874.1|WP_013055154.1|384172_384487_+|YfhH-family-protein	gnl|CDD|378063	pfam08838, DUF1811, Protein of unknown function (DUF1811). This is a bacterial family of uncharacterized proteins. Some of the proteins are annotated as being transcriptional regulators. The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.	5.92623e-60
NZ_CP018874.1|WP_078082251.1|397187_397973_+|ABC-2-family-transporter-protein	gnl|CDD|226218	COG3694, COG3694, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.22243e-45
NZ_CP018874.1|WP_013055167.1|395380_396394_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	1.65462e-121
NZ_CP018874.1|WP_013055153.1|383436_384090_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187643	cd08939, KDSR-like_SDR_c, 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR. These proteins include members identified as KDSR, ribitol type dehydrogenase, and others. The group shows strong conservation of the active site tetrad and glycine rich NAD-binding motif of the classical SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.27055e-55
NZ_CP018874.1|WP_078081429.1|390370_392122_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP018874.1|WP_013055156.1|384856_385126_+|YfhJ-family-protein	gnl|CDD|379438	pfam14043, WVELL, WVELL protein. This family includes the B. subtilis YfjH protein, which is functionally uncharacterized. This is not a homolog of E. coli YfjH, a synonym for IscX, which belongs to pfam04384. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length and contain a highly conserved WVELL motif.	7.28774e-43
NZ_CP018874.1|WP_078081427.1|385189_386170_-|metal-dependent-hydrolase	gnl|CDD|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	5.20348e-35
NZ_CP018874.1|WP_170959598.1|387876_388629_+|enoyl-[acyl-carrier-protein]-reductase-FabL	gnl|CDD|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	3.53912e-173
NZ_CP018874.1|WP_013055163.1|389664_390201_+|DUF402-domain-containing-protein	gnl|CDD|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	2.65481e-127
NZ_CP018874.1|WP_078081430.1|393879_395178_-|glutamate-1-semialdehyde-2,1-aminomutase	gnl|CDD|183493	PRK12389, PRK12389, glutamate-1-semialdehyde aminotransferase; Provisional.	0
NZ_CP018874.1|WP_078081428.1|386409_387504_+|A/G-specific-adenine-glycosylase	gnl|CDD|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	9.12365e-150

Protein sequences

>NZ_CP018874.1|WP_170959598.1|387876_388629_+|enoyl-[acyl-carrier-protein]-reductase-FabL
MMSQKVALVTGSSRGIGKEIALRLAKEGYDIVLNYARSKSAAQEVAEEIKALGREALVVKANVGKVEKIKEMFEQIDEVFGRLDVFVSNAASGVLRPIMELEETHWNWTMDINSKGYLFCAQEAAKRMEKVGGGKIVTISSLGSIRYLENYTTVGVSKAAVEALTRYLAVELAPKNIVVNAVSGGAVDTEALKHFPNRDELLDDARKHTPAGRMVEPKDMVDAVMFLVSDQANMICGQTLIIDGGRSLLM
>NZ_CP018874.1|WP_025752758.1|387538_387763_-|hypothetical-protein
MYVGRDMTALSMISKSEWKDSELAFFHHSLQQITPYLNAEGQSIHQQIIKEIEARGGLQRQEADYTHGTHVSYD
>NZ_CP018874.1|WP_078081428.1|386409_387504_+|A/G-specific-adenine-glycosylase
MKQSKDIVQNFDIRAFQDDLISWFEQEQRILPWRQDQDPYKVWVSEIMLQQTRVDTVIPYFNNFISKFPTIKDLAYANEDDVLKAWEGLGYYSRARNLQTAVREVHEQYGGEVPNTPAEISKLKGVGPYTTGAILSIAYGVPQPAVDGNVMRVLSRILSVWDDIAKPKTRKLFEDIVHEIISKHNPSYFNQGMMELGAIVCTPTSPSCLLCPVREHCRAFEEGVQNELPVKSKKKAPRALQLAAAVIRDEEGNYLIHKRPSKGLLANLWEFPNIEVDLSIAPDHQQLHAFIQNEYGADIKIHAPFTTIQHVFSHIVWNITVYEAELISDISALKNLKVVSEKDLEQYAFPVSHQKILKEYLLVK
>NZ_CP018874.1|WP_078081427.1|385189_386170_-|metal-dependent-hydrolase
MDTGTHIAMGIALGGLATLDPTVSANTATLDAVMIGVMAGSLAPDLDTVLKLRNNAQYIRNHRGITHSIPAVILWPLLIVLILSLLLPGANLLHLWMWTFAGVIIHVFVDIFNAYGTQALRPFTNKWIALGVINTFDYVIFSAHVLAIIIWFSGAEPGPTFITLYVLLAFYYGLRFYMRHQIAKKLRKQFPDVIKLNISPTMRFTHWHLAVTTEKYFHVGRAIGEEIFIYDTFDKVPIPESAVIEVAKKDENLSAFLSFSPIYRWELDEYNDHIEVRFIDLRYRSKDYYPFVAVVQLDYDLNIICSYTGWIFSEKKLRKKLDYLPH
>NZ_CP018874.1|WP_013055156.1|384856_385126_+|YfhJ-family-protein
MNDIFERLTNQLLNKNSSLSYAQARTWVELFWEDFESSYAKAGYDYKGKEATEKVVTMYINSYGDKLHEIAVKNPKYQHLLNNDDYLKH
>NZ_CP018874.1|WP_013055155.1|384565_384721_-|small,-acid-soluble-spore-protein-K
MRNKAKDFPNQHHTKFEGEPRAKAEYASKRANGTINTHPQERMHASNEREE
>NZ_CP018874.1|WP_013055154.1|384172_384487_+|YfhH-family-protein
MSEKRYSDMTTYELQQEIGSLQEKARKAEQLGMVNEYAVLERKVTMARSYLLDPETFKAGEVYEIQGDPGSYFKIDYMNGVFAWGFRLGSPQNEEALPISMLKK
>NZ_CP018874.1|WP_013055153.1|383436_384090_-|SDR-family-NAD(P)-dependent-oxidoreductase
MKTVLITGGATGLGKELAKFYAKDYNVILAGRNQYKLKEAQHELGDNVYTMSVDITKYEEVGKSVEKLLVQHSVDILINNAGIGHFGPLTDYTKQAIDEVIDTNVKGTIFLTQALMPHLLTRPEPKVMNIISTAGLRGKANESVYVASKFGVRGFTESLKVEYKDTSLHVIAAYMGGMNTPFWDHNNHIKDKSRLRSASEIAEIIYKQQNDSEDILF
>NZ_CP018874.1|WP_013055152.1|382336_383146_+|recombination-regulator-RecX
MPVVTKITTQKNSGERYNVYLDYGKGEEFGFGVDENVLIKYDLKKGRELDEFELTEIQYADDEKKAYNLAITYLSYRMRSEKEVHDYLKKKEINSTIIQQVIQKLVSHRYLNDEEFAKAFVLTQMNTTSKGPNVIQRELKEKGISDSIITLSLCEYPEEQQIQTAVKLIEKLKGKYKKLSQVMMKQKMEQALAVKGYSFSIIQEAFQRTNTEKESDEAWEALQYQGMKVHRRFSKYEGWEYQQKMKQALYRKGFSIDQIQSFLDSIEEE
>NZ_CP018874.1|WP_013055151.1|381338_382241_-|TIGR01777-family-protein
MKIVIAGGTGFVGKALTKHFLTQKHYVYILTRNADKAARDPKLKYVEWMQENSQPEEHVEGADVFINLAGVSLNSGRWTDERKKAIVESRLSSTQEILRIMAALPEKPSLYVNASAVGYYGTSTTETFTEASPSMGTDFLAETVKKWENEALKAMELNIRTVLTRFGVILGKDGGALPSTALPYKLFAGGTVGSGEQWMSWVHLQDVVKIIDYCIHTEQIEGPVNVTAPNPVQMKEFGKTIGKVLNRPHWMPVPSFGLQLLMGEMSMIILKGQRVLPEKLIQQNYIFTYTVLEDALRDLL
>NZ_CP018874.1|WP_013055162.1|389208_389469_+|hypothetical-protein
MKKFDELVTQQLETMDQLLFLQSEIERCQEIEGELIKLHEEAKLHSVQGEISEMKLKLKEIQLTFEAQTEDIIRTYKSEGACSTLA
>NZ_CP018874.1|WP_013055163.1|389664_390201_+|DUF402-domain-containing-protein
MGIPVEGETIQIHSYKHNGHIHRVWDRTTVLKATNNLVIGGNDRTVVTESDGRTWVTREPAICYFHAQQWFNVIGMIREDGIYYYCNISSPFIYDDNEALKYIDYDLDIKVYPDMTYTLLDEDEYEKHRKEMNYPEVIDRILHNHVEELKGWIRQRKGPFAPDFIDIWYERFLTYRHS
>NZ_CP018874.1|WP_078081429.1|390370_392122_+|ABC-transporter-ATP-binding-protein
MGSIRRYMKFVQPYKWQIVGTVLIGIIKFAIPLLIPLLLKYVLDDIVNGHGMSSSEKVHKMVTIMGISFVIFLVLRPPIEYYRQYYAQWVSSKVLYDIRDQLFSHIQKLSLRYYANTRAGEVISRVINDVEQTKNFVITGLMNVWLDMMTIVIAIVIMFTMNVPLTLVSIILLPVYAFSVKYFYSRLRHLTRVRSQALAEVQGHLHERVQGISVIRSFAIEPHEQKQFDKQNSNFLQKAINHTNWNAKTFAVVNTITDLAPLIVITFAGYQVITESLSVGTMVAFVAYIDRLYNPLRRLVNSSTTLTQSVASMDRVFEFIDEEYDITDKKDAKECTELHGKVQFEHISFAYEEEEKPVIHDINLDVEKGKSVAFVGMSGGGKSTLISLIPRFYDVTEGKILIDDIDIKTYKVRSLRDKIGIVLQDTVLFSDTVKNNILLGKPGATDEEVIAAAKAANAHDFIMNLPEGYDTKVGERGMKLSGGQKQRISISRVFLKNPAILIFDEATSALDLESEHYIQEALAELAKDRTTFIVAHRLSTITHVDEIVLLENGRVVERGSHEELIKKKGHYYQLFNVQQLDTI
>NZ_CP018874.1|WP_013055165.1|392157_393246_-|aromatic-acid-exporter-family-protein
MKLGARILKTGIAITLSLLLGEFLSLPSPIFAAIAAVFAIQPSIYRSYLTILEQIQANVIGAASAVCFGLIFGTHPIIIGFTAVVVIAVNLKLRINNTIGLALVTVIAIMENPGDNFVEYALIRFGTVLLGVFSAFIVNLIFIPPKYETKLYYKIVSTTEEIIKWIRMNLYHASEHTLLKEDIEKMKDNVAKMNQLFDFYKEERTYSTKKRFVKSRKLVLFRQMITVTTRALTTLKLLHRVENDLQVMPQQFQDLIKSEVECLLMYHEQVLLKFIGKLRVQPTTTVPNEACVGKRALIDKFMQYKIYDNDEENKVIYHIFPLISVIIEYSEELEHLDKLIDTFQNYHKDDNSFDINHQRQED
>NZ_CP018874.1|WP_171843209.1|393569_393743_-|hypothetical-protein
MIRGQGEDSCGKSRTGETPQERMRRGGLAAARGKRSLAWKSTAVSQAVQLMYPICSS
>NZ_CP018874.1|WP_078081430.1|393879_395178_-|glutamate-1-semialdehyde-2,1-aminomutase
MQFTKSEQLHAEALEHIVGGVNSPSRSYKAVGGGAPIAMEKASGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITKAAETGVLYGTPTAHEVTFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVITVPFNDIEPYKEALEKWGDQIAAVLVEPIVGNFGIVEPEPGFLEQVNELTHEAGALVIYDEVITAFRFMYGGAQDLLGVKPDLTAFGKIIGGGLPIGAYGGKKEIMEKVAPLGPAYQAGTMAGNPASILSGIACLEVLKQEGVYEQLDKLGAMLEEGILKHARTYNMPIIINRLKGALTVYFTTETVKNYEQAENTDGELFARFFKLMLHQGVNLAPSKYEAWFLTTAHTEQDIAETLEAVEKAFKQLSEER
>NZ_CP018874.1|WP_013055167.1|395380_396394_+|ATP-binding-cassette-domain-containing-protein
MKNAIEVNQLRKEFKAYSSRSGLKGAFRDLFTRNYRVMKAVNDISFTVKQGEMVGYIGENGAGKSTTIKMLTGILTPTSGDITVNGMNPHKEREKFAQTIGVVFGQRSQLWWDIAVQESFRLLKKVYKVSDEDYNAHMEHVIQTLDIGPLLDKPVRKLSLGQRMRCELAAALIHNPPLLFLDEPTIGLDVLVKLKIRQFLKEINEKYNTTILLTTHDLADIEALCERVVMLDEGSIIYDGSLQKLRSNWGDLKQVTFEFGTAPNKEQLKLLTQGMPVNWIEGDQKYLWTAQLQNKGDLMSQLIAKVVAKHEISDINIEEISTEEIIRNIYEEGVVNG
>NZ_CP018874.1|WP_013055168.1|396386_397178_+|ABC-2-family-transporter-protein
MDKYIEMIRIRFLMMLAYRTNYYSGILIYAINIGAYYFLWSAIYGGKENIQGLSITQMTTYVAVSWMARAFYFNNIDREMAMEIKDGKVAVELIKPYSYLGMKTMQGLGEGIFRLLFFSVPGMIIVAFLFPVQFSANAATWLYFGLSLIFSFIINTQINLLTGITTFFLFNNDGLIRAKRVVIDLFSGLLLPISFYPLWAQHIMSYFPFQAISYIPSMIFTNGFKGQEVINALITQAVWSGLLFIPIACLWNIAKKKMVIQGG
>NZ_CP018874.1|WP_078082251.1|397187_397973_+|ABC-2-family-transporter-protein
MFYFSIFFQYISQYMKTRLQYRTDMVVEIISDLLFQTVNLIFILVVFGHTQSLHGWSREEIIFIYGFFLVPFAIFSSFFNIWDFNERYIVKGEMDRILTRPIHSLFQVILERIELESLFGGITGIAVMAYAASSLHLHFQWYDVFIFLLFILGGALVYAGIFIALASIGFWSDARTSIMPTIYNIGNYGRYPVDIYNNVIRYVLTWILPFAFVGVYPAAYFLGRSEWYGYAFLTPVMGIVFFVISIFLWNTGVKKYRGAGN
>NZ_CP018874.1|WP_013055170.1|398065_398458_+|two-pore-domain-potassium-channel-family-protein
MVVFLILVIIVFVIGSMKFLFEKELGEFHFFSIGHFFVLFYSYITVLLGFSLIYTVCEMGSIPVLSGGFEHEGHYFYTLFNSMYFSAATLFSVGYGDMYPVGIGKLFATFEAFIGYIMPAIFVMRTVTRT

Crispr_ID: NZ_CP018874_2

• CRISPR_ID: NZ_CP018874_2
• CRISPR_location: 971022-971117
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018874_2

Consensus_repeat	Method
TGTAACTATAATGGTTACAACGA	CRISPRCasFinder

spacers of NZ_CP018874_2

>2.1|971045|50|NZ_CP018874|CRISPRCasFinder
GCTGAGAAGAATTAGCAGTGCTATAAAAGGCTCAAATTTTTTGTGTTTTA

CRISPR arrays and Neighbor proteins around NZ_CP018874_2

CRISPR arrays

The CRISPR arrays of NZ_CP018874_2

>merge|NZ_CP018874|2|971022-971117|CRISPRCasFinder
TGTAACTATAATGGTTACAACGAGCTGAGAAGAATTAGCAGTGCTATAAAAGGCTCAAATTTTTTGTGTTTTATGTAACTATAATGGTTACAACGA

>NZ_CP018874|2|2|971022-971117|CRISPRCasFinder
TGTAACTATAATGGTTACAACGA	GCTGAGAAGAATTAGCAGTGCTATAAAAGGCTCAAATTTTTTGTGTTTTA
TGTAACTATAATGGTTACAACGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018874.1|WP_064472217.1|976639_978064_+|diguanylate-cyclase	unknown	unknown	gnl|CDD|226229
NZ_CP018874.1|WP_078081513.1|975175_975787_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NZ_CP018874.1|WP_014461319.1|973542_974085_+|peroxiredoxin	unknown	unknown	gnl|CDD|239313
NZ_CP018874.1|WP_064471356.1|969141_970470_+|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238618
NZ_CP018874.1|WP_013055685.1|964855_965812_+|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl|CDD|163676
NZ_CP018874.1|WP_013055690.1|971138_971771_+|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|225462
NZ_CP018874.1|WP_013055696.1|975779_975926_+|YvrJ-family-protein	unknown	unknown	gnl|CDD|378969
NZ_CP018874.1|WP_029324910.1|967502_968378_+|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl|CDD|224007
NZ_CP018874.1|WP_013055697.1|975930_976158_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|184493
NZ_CP018874.1|WP_013055701.1|978092_978266_-|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl|CDD|237837
NZ_CP018874.1|WP_013055693.1|974205_974649_+|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NZ_CP018874.1|WP_029324907.1|960693_961590_+|shikimate-dehydrogenase	unknown	unknown	gnl|CDD|183585
NZ_CP018874.1|WP_078082252.1|959557_960178_+|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|378149
NZ_CP018874.1|WP_013055689.1|970517_970715_-|cold-shock-protein	unknown	unknown	gnl|CDD|224197
NZ_CP018874.1|WP_055989280.1|974797_974977_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013055684.1|963647_964856_+|CoA-transferase	unknown	unknown	gnl|CDD|367110
NZ_CP018874.1|WP_151874519.1|965963_967463_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143467
NZ_CP018874.1|WP_053486894.1|971943_972930_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP018874.1|WP_029324906.1|958387_959368_+|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176232
NZ_CP018874.1|WP_013055683.1|962231_963536_+|MFS-transporter	unknown	unknown	gnl|CDD|340877

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018874.1|WP_064472217.1|976639_978064_+|diguanylate-cyclase	gnl|CDD|226229	COG3706, PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms].	4.3871e-59
NZ_CP018874.1|WP_078081513.1|975175_975787_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.31402e-10
NZ_CP018874.1|WP_014461319.1|973542_974085_+|peroxiredoxin	gnl|CDD|239313	cd03015, PRX_Typ2cys, Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. The functional unit of typical 2-cys PRX is a homodimer. A unique intermolecular redox-active disulfide center is utilized for its activity. Upon reaction with peroxides, its peroxidatic cysteine is oxidized into a sulfenic acid intermediate which is resolved by bonding with the resolving cysteine from the other subunit of the homodimer. This intermolecular disulfide bond is then reduced by thioredoxin, tryparedoxin or AhpF. Typical 2-cys PRXs, like 1-cys PRXs, form decamers which are stabilized by reduction of the active site cysteine. Typical 2-cys PRX interacts through beta strands at one edge of the monomer (B-type interface) to form the functional homodimer, and uses an A-type interface (similar to the dimeric interface in atypical 2-cys PRX and PRX5) at the opposite end of the monomer to form the stable decameric (pentamer of dimers) structure.	1.34409e-107
NZ_CP018874.1|WP_064471356.1|969141_970470_+|amidohydrolase-family-protein	gnl|CDD|238618	cd01293, Bact_CD, Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi, but not mammalian cells. The bacterial enzymes, but not the fungal enzymes, are related to the adenosine deaminases (ADA). The bacterial enzymes are iron dependent and hexameric.	7.09159e-112
NZ_CP018874.1|WP_013055685.1|964855_965812_+|hydroxymethylglutaryl-CoA-lyase	gnl|CDD|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	2.18557e-151
NZ_CP018874.1|WP_013055690.1|971138_971771_+|NAD(P)-dependent-oxidoreductase	gnl|CDD|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	1.6882e-84
NZ_CP018874.1|WP_013055696.1|975779_975926_+|YvrJ-family-protein	gnl|CDD|378969	pfam12841, YvrJ, YvrJ protein family. This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterized.	8.32281e-10
NZ_CP018874.1|WP_029324910.1|967502_968378_+|sugar-phosphate-isomerase/epimerase	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	7.08418e-14
NZ_CP018874.1|WP_013055697.1|975930_976158_+|helix-turn-helix-domain-containing-protein	gnl|CDD|184493	PRK14082, PRK14082, hypothetical protein; Provisional.	2.40722e-08
NZ_CP018874.1|WP_013055701.1|978092_978266_-|twin-arginine-translocase-TatA/TatE-family-subunit	gnl|CDD|237837	PRK14861, tatA, twin arginine translocase protein A; Provisional.	4.96868e-23
NZ_CP018874.1|WP_013055693.1|974205_974649_+|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	5.95691e-24
NZ_CP018874.1|WP_029324907.1|960693_961590_+|shikimate-dehydrogenase	gnl|CDD|183585	PRK12548, PRK12548, shikimate dehydrogenase.	1.55598e-132
NZ_CP018874.1|WP_078082252.1|959557_960178_+|VTT-domain-containing-protein	gnl|CDD|378149	pfam09335, VTT, VMP1, TMEM41, and TVP38 (VTT) domain. The VTT domain was previously called the SNARE-associated domain, but was renamed as there seems to be no evidence for association with SNARE proteins.	4.96482e-13
NZ_CP018874.1|WP_013055689.1|970517_970715_-|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	8.42897e-30
NZ_CP018874.1|WP_013055684.1|963647_964856_+|CoA-transferase	gnl|CDD|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	5.40775e-141
NZ_CP018874.1|WP_151874519.1|965963_967463_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143467	cd07149, ALDH_y4uC, Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1. Uncharacterized aldehyde dehydrogenase (ORF name y4uC) with sequence similarity to the moss Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123) believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and similar sequences are included in this CD.	0
NZ_CP018874.1|WP_053486894.1|971943_972930_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	6.17712e-65
NZ_CP018874.1|WP_029324906.1|958387_959368_+|zinc-binding-dehydrogenase	gnl|CDD|176232	cd08271, MDR5, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	4.54519e-153
NZ_CP018874.1|WP_013055683.1|962231_963536_+|MFS-transporter	gnl|CDD|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.57432e-90

Protein sequences

>NZ_CP018874.1|WP_013055689.1|970517_970715_-|cold-shock-protein
MVQGKVKWFNAEKGFGFIEVEGQDDVFVHFSAIQGEGFKSLEEGQEVTFEIEDGARGPQAANVQK
>NZ_CP018874.1|WP_064471356.1|969141_970470_+|amidohydrolase-family-protein
MLLHLINVRLPIMHDHALFEVKISNGMYTSIVLQNGYLEGDEFFPLHAAVLGKETSLDAQGRVLLPGFVDMHMHLDKAHSLPQVPNISGTLQEAIKNYSSSLPAFPEEEIKQRMFKTALQALANGTTTIRTHIDFDCSMEEDSLFRSLQAAVEVRDELSPYMDMQVVPLFSNLDIDDMHKMNKIERAFDLEIDAIGGCPHLARNPEKEIDALFSLAQAYNKPLDLHVDESDDPSVDTIINIAQRTIELNMEGKVVVGHLCSLGGMTDAKVKEILNLLKQAKIGVVTLPASNLYLQGREDKGIVRRGVTRIRDIQKAAIPIATASDNVNDPFHPFGKADLLQVGLLTAYAAHMGSPDDQRQLLRMITSIPARLIGKEKYGVEEGNEANFVLLNVQSVQEIWTELPETRFVFNKHRWLSVKETHQRLADTNLTNLWQENQILIG
>NZ_CP018874.1|WP_029324910.1|967502_968378_+|sugar-phosphate-isomerase/epimerase
MPNQFSLAYLTVLGCSPPEMTYMAAKAGYDFVSLRPIYMGLPGEPNYALTENKQLMRETKSAMSETGVKLLDIELARIYEGVDPKRYLPAMEAAAELGGRHVLSSIWTDDRNFGIECFAELCDLAKPFGLTIELEFVPIASVYNLKGAMDVLHTANRENAGLMIDIHHFHRSGDKVEDLEDVPREWFRYLHLCNASAEIPSSKEEMTRVLREERLYLNEEGIDVASIINRIPQVPYSIELPNVKRANELGYEEFARQCLQTAKQYLDKHPRKKYVSHDAVGQDQLRFHSTR
>NZ_CP018874.1|WP_151874519.1|965963_967463_+|aldehyde-dehydrogenase-family-protein
MIETIEKKSQPYINGGWIIENREVALIKNPYSGEVIGEQLLANEEDVEKALASAYEAKKHVAALSSYQRSKILKKAALLLEQEKEKFARLISLELGKPLKNTLDEVARSIETLELSGEEAKRLIGETLPGDVSERGAQAIASTFRVPVGVVAAITPFNAPLNLVCHKIGPAFAAGNSVILKPSSQTTLIATELLKLLLRAGFPKNAVNMVLGRRQVAQQIVKDDRVNIISFTGGTVASKNICELAGMKKVLLELGGNAATIVHNDADLNRAAAMCAKTGFSNSGQSCISVQRIYVHQSVVSEFTNLLKDEVLTLKIGDPLLPDTDVGCVVDVHAAARVTSWIDEAVQSGAQVICGGKRRGATVEPTVLLNPSKESKVICEEVFGPIISIVPYATIEEAIEETNDSAFGLQAGIFTNKMDLAYKVAHSLEMGGVVINGTSNFRLDHWPYGGVKNSGIGREGPRYAVEEMTETKMIVLRLLQRIKIKSICRTFISIYRHFN
>NZ_CP018874.1|WP_013055685.1|964855_965812_+|hydroxymethylglutaryl-CoA-lyase
MNTIQKIELPEKVIICEVAPRDGFQAEHEWIPTEEKISIIRQLAKTGIQSMEITSFVHPRAIPQLKDAEQVVESVQDLTNIKFRALVPNVKGAQRAIDAGVKKLKLMLSATDSHSLSNANCSVEEAQKGFYPIIELAEKHNVKVGGSISVAFGCPYEGTVAIERISSIVERYKMMGVEEISLADTTGMANPQQVYRMLGFLKQNYPGIIFSMHLHNTRGMAFSNVVAALQQGVIHFDSSIIGLGGCPYAPGATGNIATEDLVHGLSEMGIHTGIDLNKLIEAAKEVKQVIGHDGGSYMLQAGPCSQLHAKPKVQEKLV
>NZ_CP018874.1|WP_013055684.1|963647_964856_+|CoA-transferase
MLTKNYGPLTGVQILDISTMIAAPFGATLLADLGAEVTKIELPGKGDTLRTVGPWKGTEPLRWPGLARNKKSVTLDIRSEEGAEIFKKLISGVDILIENFRPGTLEKWNLGYEELKKVNPKLVMVRVSGYGQTGPYREKAGFGTPGTAFSGHTYLQGYSDRPPVSPSYSLLDYVTGIYTAFACVSAIYHRDVHEQPEGQVVEMGLYESIFRMMEFLIAEYDQNGKVRERSPGLAGHSSPAGTYETKDGKFVVLVCSTDSTFDRLAEAMERKDMLKDPRYYTNVERLKHDHEVQEIVSNWIKSFTQDELQAKLDSFGVPVSPIYSIEDIFNDPQYRERENIVEVEHPRLGKIKVPGVVPKFSHTPGAIRHRAPELGEHNEEILGGKLGLSSEDLAVLKEKGVI
>NZ_CP018874.1|WP_013055683.1|962231_963536_+|MFS-transporter
MKKHRWSIVFLIAVGVVVNYFDRINMSIAMPLLQKEFNLTAGQMGIFLSAFAWSYALLQLPIGPLLDKIGVKWVTRVATVIWTVACLLTAVANGWGLIILSRVLLGVGEAPFFPSAAKAVSHWVPRQERGKAIAAYDSQSKLSNAIGAPILALIVTEWGWRGGFLATAILSFIYAIVYWIWYREPHEDERLTKEEYDYIVQGGSQSSEEAKGSAMENIRYLLTKRKVWAVFIGFAAYGYSWFLFLTWLPGYLATEMNMSILKSGWYSAIPWIVGTITEIVIGGWLVDRLINKGYNRTRVSKFFLVIGMVFGLSIIGAAFTHSANVAVFWISTALGGLVVTSAVAYSIPTFIAPKGTVGTLTGLLTFGNNSMAIVAPITTGFIVQATGSFMYAFLLAAAFLVIGILSYTFLLTDLDPIESKESILLEEKELTLEK
>NZ_CP018874.1|WP_029324907.1|960693_961590_+|shikimate-dehydrogenase
MKSVGRINGKTQLIGLLATPIGHSLSPSMHNMAFKKLGLNYAYLAFEVGNDSLEDAIKGLRALNVKGFNVSMPNKTKILPFLDELADSAKFSGAVNTVVNDNGVLVGHSTDGMGYIRNLKEHGVDITGKKMTLIGSGGAATPIAIQAALEGLEELTIFARDDEFYSKAVENVKIINEEMKHVSCKAKLYSLEDTDMLREEIRTSDILTNGTGVGMKPLEEFSIIEDISMLRPDLIVTDVVYMPMRSKLLEQAESIGCHTINGIGMMIWQGAMAFELWTGKEMPVEYIKEQMFEPSLQY
>NZ_CP018874.1|WP_078082252.1|959557_960178_+|VTT-domain-containing-protein
MKEREICMIERRKKVQGFIDFVQNLGIVGIFIATAIEAAAIPFPCTLSILLIGSVLQLSIWKILIVSAVNTVIYIAFNYIPFVMGYRFESITKRWFGEKNIKRAQKWFRKYGKWSITISRPISIANYITYLAGLSKIKSKDFVLYSTLGIFPWFVFLLYVGGLGDIEKIQKYLHDVDRLIIVILIIGVTVGAGWWMKKRRESHAQE
>NZ_CP018874.1|WP_029324906.1|958387_959368_+|zinc-binding-dehydrogenase
MKALLLQDKNKWTEMKVEEIEKPLPNKGEVVVEVHAVGLNPVDYKTATNGNPHWTYPHILGLDVAGTIDAVGEGVVDWKKGDRVVYHGDFMKKGGYAEYAVTTAHSISRIPDAVTFEEAAALPTAGYTAYEALFRKLPMNHIQTILIHGGAGGVGGFGVQLAKNAGKTVFSTASAHNHEYVKSLGADYVIDYREENVVEKVLELTNGRGVDAVLDTVSAKNATDSLDMIAYRGHLAHIAGAPDYTKVKPFTKVISYHEVALNAAHHIDDMIAQADLAKMGDELLALVAEKKVAPMIERIISLKEVPSALEELSKRHVKGKIITKVK
>NZ_CP018874.1|WP_013055690.1|971138_971771_+|NAD(P)-dependent-oxidoreductase
MKIGVIGATGKAGQLIMEEAKQRGHEVTAIVRNASKLKNQTNVMEKDIFAITSKDIEQFDAVVDAFNAPPGSEQLHVESIQSLIKVFQGVQTRLAVVGGAGSLFVDAEKTTPLMSTEGFPAAYYPTASNMGKGLKELEKSTVNWTYLSPAAFFDAEGARTGAYQLGKDHVITNSQNESYISYADYAIALIDELENKNHVNERFAVVGEKA
>NZ_CP018874.1|WP_053486894.1|971943_972930_+|Gfo/Idh/MocA-family-oxidoreductase
MIRFGVIGTNWITDRLLESAQYVDDFQLAAVYSRTIEKAEEFAGKYDIPHIFTDLEEMAASAEIDAVYIATPNAYHAEQAILFLKNNKHVLCEKPLAANAAEVTRMIQTAKNHKVLLMEAMKSTLLPNFKVIQENLHKIGPIRKYVASYCQYSSRYDKYKEGIVLNAFKPELANGSLMDLGVYCLYPLITLFGGPHKIKATAFMLESGVDGEGSVALEYEDRDAVIMYSKITNSHLPSEIQGEKGSMIIDKIHTAEKVEIRYNDGRVEELTVDQPYPAMYYELNEFVELLKQGKMESDTNSYENSYLTMHVMDKVREQIGLVYPNDEK
>NZ_CP018874.1|WP_014461319.1|973542_974085_+|peroxiredoxin
MAERMVGKQAPRFEMEAVLANKEFGKVSLEENMKNGKWTVLFFYPMDFTFVCPTEITALSDHYEEFEDLDAEVVGVSTDTIHTHLAWINTDRKDNGLGDLNYPLAADPTHAVARDYGVLIEEEGVALRGLFIINPEGELQYAVVNHNNIGRSVEETLRVLQALQTGGLCPANWKPGQKTL
>NZ_CP018874.1|WP_013055693.1|974205_974649_+|TlpA-family-protein-disulfide-reductase
MKLREQMPELTGATSWINDEVTKEDLVGDKATLIHFWSVSCHLCKEAMPEVNDLRDEYDDQLNVVAVHMPRSEDDLDMGVIEAMAMGHDITQPIYVDSEHKLTDAFENKYVPAYYVFDKEGQLRHFQAGGNGMPMLRKRINRVLGEE
>NZ_CP018874.1|WP_055989280.1|974797_974977_+|hypothetical-protein
MIGGQSEDSCGKSGTGETPQERMRRGGSPAARGKRSLARKSTAVSQADQLMYPICSSLN
>NZ_CP018874.1|WP_078081513.1|975175_975787_+|sigma-70-family-RNA-polymerase-sigma-factor
MTQLYSQQEKRHDKECTFHTFLTNHSATLQTHIMNTFLTPERYERLQKAVVKNDTKEQILLNKEFHQFYSEVRLLHYINKLCRHYSRDVMRVKEKERSYIPLRLQQPAALGGNRTVEDMLGVQDGAVWEHEFLGNQLENRILHHAFRQLTAKQQCMLHLIIVERWTHKEIAAYFSISQQAVSNHYQRALSKLKKIMKVSDRYV
>NZ_CP018874.1|WP_013055696.1|975779_975926_+|YvrJ-family-protein
MFDPQWLQLVGNVGFPAVLSFYLLLRVENNIKRLEEKVEELTTDLRKK
>NZ_CP018874.1|WP_013055697.1|975930_976158_+|helix-turn-helix-domain-containing-protein
METLYELVNKVKAGDEEASRRLLKKLEPKLNKAVQSFSLHEREDVKQDLKIKILSAVKTFDFSKTPGLWEFLRHK
>NZ_CP018874.1|WP_064472217.1|976639_978064_+|diguanylate-cyclase
MYRLIYYGCSYGLLGSILMIYTIKIDSTIILDLRFLAVTIVCLYAGMVPAIIAACIIGVMRLLLFGITASGIIGAATIIVMALLSGWTVRLPYRPFIRFQLMNSISLLCVFFSLSFLFKDIKHAATIIIYLLPASFIGGCLVYLVGRYIYVSRVTTSQHKKLSKMFSVMVQNAKTGTMIETPEREVAVINQTFCDMFDIPGPPNQYVGLKSNQLFLSHAPMLKDPARFLKTVESTVYSKESIVDEEITFINGKIYARDYIPIYEGHVYIGHYWEYRDITEKKKAECDLRKANKKLEMLSMKDGLTGLNNRRSLDKQLEIEWGYAKKEKEPLSFLLFDIDYFKAYNDTYGHIQGDECLKEVANIAKSVVFDEPAFVARYGGEEFGILLPRANQYEAIKMAEAIRQQVEQRGIIHQASDVFKCVTISVGIMTVVPSENIPPISIVHQADQALYEAKRTGRNRISVYSHHKEADSNV
>NZ_CP018874.1|WP_013055701.1|978092_978266_-|twin-arginine-translocase-TatA/TatE-family-subunit
MNLGFGEIALIVFVALLLFGPKKLPELGKAAGKTLKEFKNATKGIMEEDEKEKAPPK

Crispr_ID: NZ_CP018874_3

• CRISPR_ID: NZ_CP018874_3
• CRISPR_location: 1182139-1182300
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP018874_3

Consensus_repeat	Method
AGAACGACGAGTAGAACG	CRT

spacers of NZ_CP018874_3

>3.1|1182157|30|NZ_CP018874|CRT
ACGAGTAGAACGACGAGTAGAACGGCGGGT
>3.2|1182205|18|NZ_CP018874|CRT
GCGGGTAGAACGGCGAGT
>3.3|1182241|42|NZ_CP018874|CRT
GCGGGTAGAACGGCGAGTAGAACGGCGAGTAGTGCGGCGAGT

CRISPR arrays and Neighbor proteins around NZ_CP018874_3

CRISPR arrays

The CRISPR arrays of NZ_CP018874_3

>merge|NZ_CP018874|3|1182139-1182300|CRT
AGAACGACGAGTAGAACGACGAGTAGAACGACGAGTAGAACGGCGGGTAGAACGGCGAGTAGAACGGCGGGTAGAACGGCGAGTAGAACGACGAGTAGAACGGCGGGTAGAACGGCGAGTAGAACGGCGAGTAGTGCGGCGAGTAGTGCGACGAGTAGAACG

>NZ_CP018874|3|1|1182139-1182300|CRT
AGAACGACGAGTAGAACG	ACGAGTAGAACGACGAGTAGAACGGCGGGT
AGAACGGCGAGTAGAACG	GCGGGTAGAACGGCGAGT
AGAACGACGAGTAGAACG	GCGGGTAGAACGGCGAGTAGAACGGCGAGTAGTGCGGCGAGT
AGTGCGACGAGTAGAACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018874.1|WP_078081589.1|1176788_1177295_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP018874.1|WP_078081588.1|1175336_1176089_-|DUF45-domain-containing-protein	unknown	unknown	gnl|CDD|307807
NZ_CP018874.1|WP_013055916.1|1184815_1186117_-|NCS2-family-permease	unknown	unknown	gnl|CDD|225161
NZ_CP018874.1|WP_029325059.1|1186336_1187287_-|GHKL-domain-containing-protein	unknown	unknown	gnl|CDD|225827
NZ_CP018874.1|WP_013055905.1|1176342_1176585_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_064471459.1|1188917_1190084_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224582
NZ_CP018874.1|WP_013055914.1|1183245_1184415_-|MFS-transporter	unknown	unknown	gnl|CDD|340883
NZ_CP018874.1|WP_013055901.1|1173389_1173725_-|DUF1049-domain-containing-protein	unknown	unknown	gnl|CDD|227703
NZ_CP018874.1|WP_013055913.1|1182524_1182971_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP018874.1|WP_013055919.1|1188178_1188916_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213233
NZ_CP018874.1|WP_078081590.1|1177342_1178497_+|M20-peptidase-aminoacylase-family-protein	unknown	unknown	gnl|CDD|349919
NZ_CP018874.1|WP_064471460.1|1191390_1191891_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|237292
NZ_CP018874.1|WP_078081591.1|1179441_1181055_+|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl|CDD|349905
NZ_CP018874.1|WP_013082184.1|1184589_1184784_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_051390581.1|1174761_1175124_+|DUF1259-domain-containing-protein	unknown	unknown	gnl|CDD|377846
NZ_CP018874.1|WP_013055902.1|1174119_1174458_-|hypothetical-protein	unknown	unknown	gnl|CDD|378946
NZ_CP018874.1|WP_028414204.1|1178729_1178972_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_029325057.1|1181073_1181871_-|VOC-family-protein	unknown	unknown	gnl|CDD|379203
NZ_CP018874.1|WP_162245037.1|1182898_1183186_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_029325060.1|1187304_1188003_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225818

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018874.1|WP_078081589.1|1176788_1177295_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	8.82463e-12
NZ_CP018874.1|WP_078081588.1|1175336_1176089_-|DUF45-domain-containing-protein	gnl|CDD|307807	pfam01863, DUF45, Protein of unknown function DUF45. This protein has no known function. Members are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C-terminus being the most conserved region, containing three conserved histidines. This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	2.70851e-20
NZ_CP018874.1|WP_064471459.1|1188917_1190084_+|ABC-transporter-permease	gnl|CDD|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	5.97755e-26
NZ_CP018874.1|WP_029325059.1|1186336_1187287_-|GHKL-domain-containing-protein	gnl|CDD|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	2.11656e-26
NZ_CP018874.1|WP_013055914.1|1183245_1184415_-|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.29484e-57
NZ_CP018874.1|WP_013055901.1|1173389_1173725_-|DUF1049-domain-containing-protein	gnl|CDD|227703	COG5416, COG5416, Uncharacterized integral membrane protein [Function unknown].	3.22264e-18
NZ_CP018874.1|WP_013055913.1|1182524_1182971_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.71087e-08
NZ_CP018874.1|WP_013055919.1|1188178_1188916_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213233	cd03266, ABC_NatA_sodium_exporter, ATP-binding cassette domain of the Na+ transporter. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein.	4.2056e-106
NZ_CP018874.1|WP_078081590.1|1177342_1178497_+|M20-peptidase-aminoacylase-family-protein	gnl|CDD|349919	cd05669, M20_Acy1_YxeP-like, M20 Peptidase aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2. Peptidase M20 family, aminoacyclase-1 YxeP-like subfamily including YxeP, YtnL, YjiB and HipO2, most of which have not been well characterized to date. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity; substrates include indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). ACY1 appears to physically interact with Sphingosine kinase type 1 (SphK1) and may influence its physiological functions; SphK1 and its product sphingosine-1-phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. Strong expression of the human gene and its mouse ortholog Acy1 in brain, liver, and kidney suggest a role of the enzyme in amino acid metabolism of these organs.	0
NZ_CP018874.1|WP_078081591.1|1179441_1181055_+|M20/M25/M40-family-metallo-hydrolase	gnl|CDD|349905	cd05654, M20_ArgE_RocB, M20 Peptidase arginine utilization protein, RocB. Peptidase M20 family, ArgE RocB (arginine utilization protein, RocB; arginine degradation protein, RocB) subfamily. This group of proteins is possibly related to acetylornithine deacetylase (ArgE) and may be involved in the arginine and/or ornithine degradation pathway. In Bacillus subtilis, RocB is one of the three genes found in the rocABC operon, which is sigma L dependent and induced by arginine. The function of members of this family is as yet unknown, although they are predicted as deacetylases.	0
NZ_CP018874.1|WP_029325060.1|1187304_1188003_-|response-regulator-transcription-factor	gnl|CDD|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	2.24301e-44
NZ_CP018874.1|WP_051390581.1|1174761_1175124_+|DUF1259-domain-containing-protein	gnl|CDD|377846	pfam07485, DUF1529, Domain of Unknown Function (DUF1259). This family is the lppY/lpqO homolog family.	4.03693e-41
NZ_CP018874.1|WP_013055902.1|1174119_1174458_-|hypothetical-protein	gnl|CDD|378946	pfam12788, YmaF, YmaF family. This family of proteins contain 6 HXH motifs and is named after the B. subtilis YmaF protein. It seems likely that these are involved in metal binding. The function of this protein is unknown.	4.09019e-10
NZ_CP018874.1|WP_064471460.1|1191390_1191891_+|MerR-family-transcriptional-regulator	gnl|CDD|237292	PRK13182, racA, chromosome-anchoring protein RacA.	1.11005e-26
NZ_CP018874.1|WP_029325057.1|1181073_1181871_-|VOC-family-protein	gnl|CDD|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	9.98927e-28
NZ_CP018874.1|WP_013055916.1|1184815_1186117_-|NCS2-family-permease	gnl|CDD|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.63684e-147

Protein sequences

>NZ_CP018874.1|WP_029325057.1|1181073_1181871_-|VOC-family-protein
MHLSFDHLVHFSPDPIKAQKELNEYGINVVKGGIHEKWGTFNTLAYFNLSYIEWLGLRDIALAQTVTDNDLIQQLVNEHTPVGHFGRFALRTDDMDLLIKELESKNVTVKGPVAGSRQTNDGERLEWKMCFIEADHDSLPLPFFIEWGEPEEKRKPKLAALSSHQAGQLQLKNIYCAVHNLEESISKWTKLLDIQSAESYKDSLLNARCQKLYVNGGNLIFCSGTQGVVHDTLKKVGERPFLVELDHALTPQQITVQGASFKFNK
>NZ_CP018874.1|WP_078081591.1|1179441_1181055_+|M20/M25/M40-family-metallo-hydrolase
MSNKTSLYQTKEQLKKLVSELVSIPSVTGTMAEVEMAESIASYLLKLPYFQKNEQVELHSTGDGRSIVTAFVQGKNTNKTVVLVSHYDVVDVQDYGKWKKDAFHADTLTSTFYSHMEQVPAHVQKDMIKGDWLFGRGTMDMKAGIALHISMVERACNGEFDGNILLLSVPDEEVNSLGMRKAVPVLLELARKHQLDFSLMLNAEPVFSRYPGDQTNYVYSGSIGKIMPSFLCYGKETHVGEPLAGLNANLLASYLTKEIELNVDFCEKVREETSPPPTVLIQKDLKEEYSVQVPHSAVVLFNLFMLNRSLKEVTDLLLKSADKAALNVKKHYNKAARQYAAGMEGSSLDVNVWTYEELYTHAVKQHGEKYVQEMEAALLAQEDDDRNKTIKLVNSLAGLCKEAAPMMVLFFTPPLYPAVCSHDDPFVQEILSNVQAIAKEQFQVELVEQSYFGGISDLSYASLQHPLHTFNTLVANMPLWNKGYHIPLEELEELKMPVLNIGPLGRDAHQWTERLAVQYSFEILPHFIYQAIKEAHK
>NZ_CP018874.1|WP_028414204.1|1178729_1178972_+|hypothetical-protein
MSHTAVAAHTGEKALKEAVKLLGKHYQVAYRELETFYEIVVENHVRTYAVGIDIKDVQKANELEIYSSCCSKLERVGCLL
>NZ_CP018874.1|WP_078081590.1|1177342_1178497_+|M20-peptidase-aminoacylase-family-protein
MTDQLLLNKLIDIRRELHRFPELSMKEYETTKRIKKWLKHYDISIADAFQLDVGAVAEIVGGKLGPTIAIRADIDALPIEEKTNLPFASEVNGVMHACGHDFHTASIIGAAILLKQRQQELCGTVRFIFQPAEETASGAKMLVEKGVLEGVEAIFGMHNKPDLPVGTIGIKSGSLMASVDRFEIDVKGVGGHAGIPEKTIDPIAAAGQIVTSLQTIVSRNLSPFQNVVVSITQIHGGSSWNVIPDKVTLEGTVRTFQEEAREKIPALMKRTAEGIGAAFGASVDVKWYPYLPVVNNDDTLEKLVTKAAEDLSYQVVEAEQSPGGEDFAVYQQHVPGFFVWMGTAGEYEWHHPSFSLNEEALLVAASYFANLSFHFLNSFHYQKN
>NZ_CP018874.1|WP_078081589.1|1176788_1177295_+|GNAT-family-N-acetyltransferase
MKNEFRLATNDDADNLLNLTLQAYKPIRELGIPFLAATADLALVKKNISQNLCYVYEEDKKIAATVSIRMPWGEHPGPFAVPHLWWFAVDPSFARKGVGSKLLRLVEEEVIKNTFKSPGVSLGTAKEHPWLVEMYERKGYVQAKEKHLAEGYTTVFLYKKFNELHSLS
>NZ_CP018874.1|WP_013055905.1|1176342_1176585_+|hypothetical-protein
MKNKKSVSKFTCEMLYMMVITLTVIEVTNYYLIMKQEQAASIMLVITFLFAFLTTTVFYFIIRRSIIAVENLTKVMKGVS
>NZ_CP018874.1|WP_078081588.1|1175336_1176089_-|DUF45-domain-containing-protein
MYTYQTGNQTIDYKIEVVPNRTDITVQICDKEGVKVIIPRGLNENNVRSIIARKATWILKQLNGSQPAEEKPAAPKKEAVKKETAKKEAPKAAASAAKTGSFEEGDKFPYLGRQYRLNIVRGDVAKAEMTFRAKFIATVPESWNEQQINEGIGQLLTEWYQGRAGEKFQEALKSVKKAADNAPESVKWDELGEEYATTQDNTIVLNWRLLTAPLATIEYVIASQFTNADELFEDAAERKQWLSDNTLNAF
>NZ_CP018874.1|WP_051390581.1|1174761_1175124_+|DUF1259-domain-containing-protein
MLGGQGSLDENGVCLVQKFRTIRFKILGRPTRSPLVTPQFFTFEDLDSKGRALNLGETVLLQEEVNPLLTELRKRDIKVTAVHNHWLFEEPRAMYMHFESVEPPLDFARKVREAFRVLKG
>NZ_CP018874.1|WP_013055902.1|1174119_1174458_-|hypothetical-protein
MKKIGKDDFISGFVPHHNHGSVDYTSVASGHVHQCLDVTSPPIQSEDGSHIHYTEGYVVFEDGHTHHYKAYSGPAIPIGNGMHVHYYDFYTSEDNQHRHHVKGVDHPAPGDR
>NZ_CP018874.1|WP_013055901.1|1173389_1173725_-|DUF1049-domain-containing-protein
MKGQSFFILGLIFALIIAVLAVINNDPVQFNYVFGSQKWPLILIILTTAVFGGVVAASLSFVKIVQLRGQVKQKNKRIAELEEDIKQHKPVEPVVEEEPNQPATRTERAQL
>NZ_CP018874.1|WP_013055913.1|1182524_1182971_+|GNAT-family-N-acetyltransferase
MLQILEHQRVDIALQIVAVQVEAYQEEARLIGFSDIPQLTESKEDIMKSKEVFIGEMIEGKLAGVLSFEKENERLTICRLVVRPRDFRKGIGSRLLTHVLQRYSECECIVSTAEKNTPAIKLYEAHRFSIIKRTAAADNLVLVTMKRD
>NZ_CP018874.1|WP_162245037.1|1182898_1183186_-|hypothetical-protein
MENPTRSDFFIVMSILAVLIGEQGGDSCGISGSDEEAQRPPEESEVLHGNQQPIPTSACSSFVGLWINLAMSQSLFIVTNTRLSAAAVRFIIENR
>NZ_CP018874.1|WP_013055914.1|1183245_1184415_-|MFS-transporter
MNKQLGTLMFVIFMVFVGFGVIIPIVPEVIRATGASTVNLGILMASYSIASFITAPFWGKLSDIKGRRPILLWGLLGFSASFFLFSVAENSLTLMYTSRIIGGLFAGAVIPCAFAYASDSTDEENRTKAMGLLGMSIGLGFIFGPALGGVLSSFGLFVPFVISGILSLIMTAFSFFTLKESLRKESAAKVQTSRWHDFTSDFQGAMKYLYVLSFLATFTLAGLEATFQFFQIAKINATPTTIGWMFMASGLTQALIQGGVLQRFKKGNEKKLMAIGLLVSAIGFTSILLSSSAVNATLFLCIFTAGNALIRPCVLSLITMRTKVGYGSASGLTASMDSLGRIFGPLLGAFAFKLNMTLPFIIGAVVTLAALLLIQRHTALDYSEQTLSS
>NZ_CP018874.1|WP_013082184.1|1184589_1184784_+|hypothetical-protein
MPIWIVFAGIIGGLLGFGALVDYIAKKRSIELDPEEGIKNASDAEQIYVENYLYQTKENNNHFQ
>NZ_CP018874.1|WP_013055916.1|1184815_1186117_-|NCS2-family-permease
MFKLKEYNTDAKTEILAGITTFLTMIYIVIVNPVILSSAGVPFDQVFTATIISAVVATLWMALAANYPIAIAPGMGMNAYFAALVVGSNGSIDYATAFSAVFVAGIIFIILSLTSFREKLIEAIPNNLKHAISAGIGLFIAFIGLRSAGIIVANKSNLIGLGDLQSEKVVLTLIGLAITIILYTLNVNGALFFGMIITGLIAFFRGQLSFDKGLFASPHLPDGLMISNPFAAFGDVIHHDLYTVVFSFLLVTIFDTTGTMVGVAQQAGLMKGNKMPRVRQALLADSFGTTIGALFGTSPTTAYVESSSGVAAGGRTGLTGVTVAILFIVAAFFSPVVSSVSGVAAITSPALIIVGSLMMGAVAKINWNDFDEAFPAFLVVLAMPLTSSIATGIALGFISYPLMKLVKGKGKQVHPLVYVFAVLFLYQLIFLPH
>NZ_CP018874.1|WP_029325059.1|1186336_1187287_-|GHKL-domain-containing-protein
MKLFYILVLLTVFVLLFFKDLPVSLHLLLSSFIIGSFFIWRKKYQTAPLINIKKAIVITSFFLLLFSLSSPFSIGLTVIAMIGYMTDMFSSYQQYIFVTNRESSASREIQKNNELFQALRAERHDFIKHVSAVSYLLETNQRQQAQEYIQDYVEALNDTHSYIQGEHSHVASVVHQCKNQAHTWGIHMNVQLDSPLSQLPLKHLDQMNLIMNLLHNALEAAHSSEKKEITVSSMIRSGIYILEVSNSTAPLSRERQDHLFTSFHVTEKKERHEGLGTWIISELVSNYHGRLEYTYHDLTLSIKIKFPIVVASKQAT
>NZ_CP018874.1|WP_029325060.1|1187304_1188003_-|response-regulator-transcription-factor
MKVGLVDDHSYDLEKLRISLEREDDIDILFSTSSAEEAYNKIKKNEIDLLITDIEMPKLSGYELADFINAYALDIQVIFVTGHSGFAVHAFELNVLDYIMKPYSKERLLKGIQRFHQKKQSTDTRDKLILKQKTEMQVLNKQDIIFAERTGRSTTIITTNGEFSTYQSLNEIEKELTGSHFLRSHRAFIVNISYIQNFSLYTKHSYSVMFQSTEKTALITKTNLDILQKEYF
>NZ_CP018874.1|WP_013055919.1|1188178_1188916_+|ATP-binding-cassette-domain-containing-protein
MIEIKGVTKYFKEKKQTIAAVQDIHVTIAQGEIVGLLGENGAGKTTLLRMLSTVLEPSEGNMFIHGINIHKQPDKIKQRIGVLFGGETGLYDRLTARENLAYFAKFYGMSKHETKIRVEELAKRFGMKDYLDRRVGGFSKGMRQKVAIARTILHNPDVILFDEPTTGLDITSANMFRELIKSLQREGKTIIFSSHIMEEVEMLCQSIIMIHKGKMIYQGTNEQLYKEEESTDLNYIFMSRIVRGA
>NZ_CP018874.1|WP_064471459.1|1188917_1190084_+|ABC-transporter-permease
MIWHIYKKELIDCLRDRKTIIFSVLIPILLNIGMLFFVDRMMSSNQPDGMSIAVEKGSDTSVVEWLKEDRNLQVVESEDPLQTVEKGKASVALKVDKKFSDKILHMQSPDVMIYTSPDSVESSHTTEYVTAILNKQRDGIIKERLTQLNINDQTIQPFYVKEQSLSNKDNSSLIMVAIYAPMIIAIGVLGGIVPSANDIFAGEKERKTMEALLMAPIKRLHLLIGKWFTISTFGVLSGVLSTISFVLFVRYFTVTLNDALNLNNHLIAFSASLLVAITLFALLAGLILCIFSLLASSVKEAQSYTSQIVTVAILPCFLLMGKSVNELQSNVFLIPIYNVFALMKQLLYGVYDMQSLTYTIGSLSVCIIVLFTIGYTMFTKSRWVLGKG
>NZ_CP018874.1|WP_064471460.1|1191390_1191891_+|MerR-family-transcriptional-regulator
MTMKTVDVAKSLGIHPSTVLKWVKIADIELERNESGHCEFTEENVEALRKFQKNRNRQAVVKVVEKVVEKEEVVISDERAQDMQKQLDQLFLRLIENEKRTEEKAGEVVTFQILEHRSEIDRLNKVITKLENRVVELESQLKSEDSLKAKKPVPRWRSFLTGIFSY

Crispr_ID: NZ_CP018874_4

• CRISPR_ID: NZ_CP018874_4
• CRISPR_location: 1385167-1385577
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 8 spacers

Consensus repeat of NZ_CP018874_4

Consensus_repeat	Method
CGAGNAGAACGGCGAGNA	CRT

spacers of NZ_CP018874_4

>4.1|1385185|39|NZ_CP018874|CRT
CTTCGGGAAGAACGGCGAGTAGAACGGCGAGAAGAGCGG
>4.2|1385242|54|NZ_CP018874|CRT
GAGCGGCGAGAAGAGCGGCGAGTAGAGCGACGAGAAGAACGACGAGTAGAACGA
>4.3|1385314|30|NZ_CP018874|CRT
GAGCGGCGAGTAGAGCGACGAGAAGAACGA
>4.4|1385362|18|NZ_CP018874|CRT
GAACGGCGAGTAGAACGG
>4.5|1385398|30|NZ_CP018874|CRT
GAACGGCGAGTAGAACGGCGAGAAGAGCGG
>4.6|1385446|42|NZ_CP018874|CRT
GAACGGCGAGTAGAGCGATGAGAAGAATGACGAGAAGAACCA
>4.7|1385506|18|NZ_CP018874|CRT
GAACCACGAGAAGAACCA
>4.8|1385542|18|NZ_CP018874|CRT
GAACTACGAGAAGAACTA

CRISPR arrays and Neighbor proteins around NZ_CP018874_4

CRISPR arrays

The CRISPR arrays of NZ_CP018874_4

>merge|NZ_CP018874|4|1385167-1385577|CRT
CGAGAAGAACGGCGGGTACTTCGGGAAGAACGGCGAGTAGAACGGCGAGAAGAGCGGCGAGTAGAACGGCGAGAAGAGCGGCGAGAAGAGCGGCGAGTAGAGCGACGAGAAGAACGACGAGTAGAACGACGAGTAGAACGGCGAGAAGAGCGGCGAGTAGAGCGACGAGAAGAACGACGAGTAGAACGGCGAGTAGAACGGCGAGTAGAACGGCGAGTAGAACGGCGAGTAGAACGGCGAGTAGAACGGCGAGAAGAGCGGCGAGTAGAACGGCGAGTAGAACGGCGAGTAGAGCGATGAGAAGAATGACGAGAAGAACCACGAGAAGAACGACGAGAAGAACCACGAGAAGAACCACGAGAAGAACTACGAGAAGAACTACGAGAAGAACTACGAGAAGAACGGCGACGT

>NZ_CP018874|4|2|1385167-1385577|CRT
CGAGAAGAACGGCGGGTA	CTTCGGGAAGAACGGCGAGTAGAACGGCGAGAAGAGCGG
CGAGTAGAACGGCGAGAA	GAGCGGCGAGAAGAGCGGCGAGTAGAGCGACGAGAAGAACGACGAGTAGAACGA
CGAGTAGAACGGCGAGAA	GAGCGGCGAGTAGAGCGACGAGAAGAACGA
CGAGTAGAACGGCGAGTA	GAACGGCGAGTAGAACGG
CGAGTAGAACGGCGAGTA	GAACGGCGAGTAGAACGGCGAGAAGAGCGG
CGAGTAGAACGGCGAGTA	GAACGGCGAGTAGAGCGATGAGAAGAATGACGAGAAGAACCA
CGAGAAGAACGACGAGAA	GAACCACGAGAAGAACCA
CGAGAAGAACTACGAGAA	GAACTACGAGAAGAACTA
CGAGAAGAACGGCGACGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018874.1|WP_064471477.1|1376574_1377246_+|endonuclease-III	unknown	unknown	gnl|CDD|223255
NZ_CP018874.1|WP_029325131.1|1382674_1382929_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013056122.1|1389269_1390415_+|PLP-dependent-transferase	unknown	unknown	gnl|CDD|366438
NZ_CP018874.1|WP_078081618.1|1377768_1380603_-|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl|CDD|273955
NZ_CP018874.1|WP_172802871.1|1384846_1384993_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_165573332.1|1383680_1383851_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013056113.1|1382974_1383325_+|YppE-family-protein	unknown	unknown	gnl|CDD|378052
NZ_CP018874.1|WP_078081621.1|1391615_1391882_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013056128.1|1394606_1395152_-|YhcN/YlaJ-family-sporulation-lipoprotein	unknown	unknown	gnl|CDD|131944
NZ_CP018874.1|WP_064471480.1|1387067_1388186_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_029325128.1|1377232_1377733_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_078081620.1|1385851_1386937_+|CotH-kinase-family-protein	unknown	unknown	gnl|CDD|227642
NZ_CP018874.1|WP_013056115.1|1383977_1384172_-|hypothetical-protein	unknown	unknown	gnl|CDD|290882
NZ_CP018874.1|WP_013056123.1|1390398_1391580_+|PLP-dependent-transferase	unknown	unknown	gnl|CDD|366438
NZ_CP018874.1|WP_029325135.1|1388250_1388913_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013056116.1|1384401_1384815_+|hypothetical-protein	unknown	unknown	gnl|CDD|372950
NZ_CP018874.1|WP_013056129.1|1395263_1395431_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013056110.1|1380666_1381266_-|Holliday-junction-resolvase-RecU	unknown	unknown	gnl|CDD|235015
NZ_CP018874.1|WP_013056125.1|1391944_1392604_-|SIMPL-domain-containing-protein	unknown	unknown	gnl|CDD|225516
NZ_CP018874.1|WP_013056130.1|1395717_1395921_+|cold-shock-protein	unknown	unknown	gnl|CDD|224197

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018874.1|WP_013056125.1|1391944_1392604_-|SIMPL-domain-containing-protein	gnl|CDD|225516	COG2968, COG2968, Uncharacterized conserved protein [Function unknown].	6.69734e-35
NZ_CP018874.1|WP_078081618.1|1377768_1380603_-|PBP1A-family-penicillin-binding-protein	gnl|CDD|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP018874.1|WP_013056122.1|1389269_1390415_+|PLP-dependent-transferase	gnl|CDD|366438	pfam01053, Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	0
NZ_CP018874.1|WP_013056128.1|1394606_1395152_-|YhcN/YlaJ-family-sporulation-lipoprotein	gnl|CDD|131944	TIGR02898, Uncharacterized_lipoprotein_YlaJ, sporulation lipoprotein, YhcN/YlaJ family. YhcN and YlaJ are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic 40-residue C-terminal domain that is not included in the seed alignment for this model. A portion of the low-complexity region between the lipoprotein signal sequence and the main conserved region of the protein family was also excised from the seed alignment. [Cellular processes, Sporulation and germination].	1.5235e-35
NZ_CP018874.1|WP_064471477.1|1376574_1377246_+|endonuclease-III	gnl|CDD|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	2.64908e-110
NZ_CP018874.1|WP_078081620.1|1385851_1386937_+|CotH-kinase-family-protein	gnl|CDD|227642	COG5337, CotH, Spore coat assembly protein [Cell envelope biogenesis, outer membrane].	3.21639e-97
NZ_CP018874.1|WP_013056115.1|1383977_1384172_-|hypothetical-protein	gnl|CDD|290882	pfam14178, YppF, YppF-like protein. The YppF-like protein family includes the B. subtilis YppF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved LLDF sequence motif.	2.20049e-27
NZ_CP018874.1|WP_013056123.1|1390398_1391580_+|PLP-dependent-transferase	gnl|CDD|366438	pfam01053, Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	0
NZ_CP018874.1|WP_013056116.1|1384401_1384815_+|hypothetical-protein	gnl|CDD|372950	pfam14179, YppG, YppG-like protein. The YppG-like protein family includes the B. subtilis YppG protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.	1.94961e-16
NZ_CP018874.1|WP_013056110.1|1380666_1381266_-|Holliday-junction-resolvase-RecU	gnl|CDD|235015	PRK02234, recU, Holliday junction-specific endonuclease; Reviewed.	3.74142e-114
NZ_CP018874.1|WP_013056130.1|1395717_1395921_+|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.31107e-32
NZ_CP018874.1|WP_013056113.1|1382974_1383325_+|YppE-family-protein	gnl|CDD|378052	pfam08807, DUF1798, Bacterial domain of unknown function (DUF1798). This domain is found in many hypothetical proteins. The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.	1.48531e-35

Protein sequences

>NZ_CP018874.1|WP_172802871.1|1384846_1384993_-|hypothetical-protein
MKKNKHQILTSSTTDIEEVKRLNAQSGLTYNEVFTLLGENYLKNQKKK
>NZ_CP018874.1|WP_013056116.1|1384401_1384815_+|hypothetical-protein
MYTSKHYPYYEQHQPERFDLSQVHPFPQYHQQPWTEAYMPQHPYAQQQMPFGPQQIPYMNGMYQQPMYNNAGAPFNPYPKAQQQKPQPSQFQSLMSQFKSSDGNYDMNKMMNTAGQMMGAMNQLTSLVKGFSGIFKV
>NZ_CP018874.1|WP_013056115.1|1383977_1384172_-|hypothetical-protein
MYVNELQEAFIAVKQYEPQSSNELLDFAQQQYLKGFLTPMNYKAAVRELEQIGATKPDFSAQDD
>NZ_CP018874.1|WP_165573332.1|1383680_1383851_-|hypothetical-protein
MSRGKHFDHKKQGQSAVNKTNNAVASKHTEKVDYHIDTVASQDHPAVSIQSQKDFD
>NZ_CP018874.1|WP_013056113.1|1382974_1383325_+|YppE-family-protein
MNEDVKKSTEIMFQYNEVAVERLASIQQEENYEVKFFEEVKPYGDIFFKELDEWASLVTEWLKKERPKYIHVNQVETLKENLQNVVLQSFYPETREKRFKKMYHSNKYVLESILNN
>NZ_CP018874.1|WP_029325131.1|1382674_1382929_+|hypothetical-protein
MKQSMVKTSEMMTLLDSLLEQVDLVDKTMSTSINEAFTHCEETYMEQVHRIDQSLQEIEVAVYESMPSETEWSRSRREMVLHTV
>NZ_CP018874.1|WP_013056110.1|1380666_1381266_-|Holliday-junction-resolvase-RecU
MIRYPNGKAYKPLNTSSPSPKKLEASYSNRGMTLEDDLNETNEYYVSKGIAIVHKKPTPVQIVKVDYPKRSAAVIKEAYFKQASTTDYNGVYKGKHLDFEAKETRNKTSFPLRNFHEHQIEHMKQIVKQNGICFVILMFSTLQEIYLFEAQFLFPYWDAMKKDGRKSIPKADIEKKGHFMELGYHPRIDYIKTIDKLYF
>NZ_CP018874.1|WP_078081618.1|1377768_1380603_-|PBP1A-family-penicillin-binding-protein
MSDNYRSREERRRAMNDNKPEGKSQGKPKKKKKGGLFRKIVAAVLLIGIIGLIAGVGTFFAMISDAPKVDDSVLKNSFSSKVYANDGKTVVKEIGAQKRTYVQYDEIPQVVKNAFIATEDVRFYKHHGVDFYRIGGALMANFKNGFGAEGGSTITQQVVKNSFLSPKKTVKRKVQEMWLAYQLERKYSKQQILEMYLNKIYFASGEVYGIERAAEKFYGVKSVKDLTLDEAAMLAGLPKAPTTYNPVTNPENATKRRNTVLNLMAKNGFITQAEADKAKQVDVQAHLAKQTESTSKYDVFIDQVIEEVKKKTDADPFSAGLEIYTTLDTNAQDYVDDVMNNKVVNFPNDKFQAGLVVVDNETGGIQAIGGGRNRVSGGLNFATNMRRQPGSTIKPILDYGPAIENLKWSTGQPLKDEEYHYSNGTPIRNFGRNYKGWVSAREALGRSLNIPALKAFQATGADKAKEFATGLGLKLDEEDGEAYSESYSIGGFRTGVTPLQMAGAYSAFANEGMYNAPHTVTKVKFPDGTEIDLTPKPKRAMQDYTAFMMTDMMKSVVNESYGTARAVRTPGLEIAGKTGTSNFSAADKQRYNIPDAGEKDVWFNGFTPNYTISVWTGYETPKDGYILSPNETGMAKNIFKHVITHISEGKPKGSFKQPDSVVERSVEKPTGKDLKRPSGSTPSSLITKEYFVRGTAPTKVSQTFVKKEKEEKKEDKKENKKEKKDNKDVKPKITASYSGGAISVNWSASNAASDTTFTVTMSSPNGSEQLASGAGAGGKTISNPAPGATYSFTVTTNTGESASSSVKVPDSSDQATEDDSTKPEDDGTTDDNQNEDNSNTDQNNGSDQGDDSSTQPDDNQNNNNGNNNGSNNGGNNSGNTDNNNNDSGNANDGNSGNNSNNGGTTTPPADNGGSDSGSQTPQTPATPSTPVTPATPQQEPTTEN
>NZ_CP018874.1|WP_029325128.1|1377232_1377733_+|hypothetical-protein
MLPIEVPSHFICEPFYSKEDRVLEVDEKNGRNYFAYDILYDVHKETKTPWRDVQKNIRPFFEKWETQREELYTLFSVRKAKEAAPCMKQAAAMYISLLFWINGQPVRRLNRLQEDIADLTYKPINCAERLMFLLQRVSSYQAYIQLTELFNELRKQYAKMLILHKK
>NZ_CP018874.1|WP_064471477.1|1376574_1377246_+|endonuclease-III
MLTLKQIRQCLDAMAEMFPDAHCELNHRNPFDLVIAVALSAQCTDALVNRVTADLFKKYQTPEDYLAVSLEELQQDIRSIGLYRNKAKNIQKLCRMLIDEYGGEVPTDRDELTNLPGVGRKTANVVVSVAFGVPSIAVDTHVERVSKRLGICRWKDSVLEVEKTLMRKIPKDEWSVTHHRLIFFGRYHCKAQSPQCHVCPLLDLCREGKKRMKGKEKKTDVTD
>NZ_CP018874.1|WP_078081620.1|1385851_1386937_+|CotH-kinase-family-protein
MKQKEIPQYALFVNVKDLKEMHRDIWSEEVIQATMKFNKKRYDIDLLLRGSHIRKMKKKSYFIEFYSPKIFQHSKEIHLNAEYKDPSLMRNKLSLDFFSSLDVLSPQSQFINLTINGKNEGIYLQLESVDELFLKKRNLADGSIFYAVDGDANFSLMSDLDKKPKTSLLSGYEDKVVKQGDKEKLEQFIFNVNTWTNTEFEQNIEKYLNVDRYLSWLVGIICMQNYDGFVHNYALYRNHDSGRFELIPWDYDATWGRDVNGKVMEGDYVRAQGFNTLTARLLAVDGIKKRYIKKMNNVLNNQFTVEYMKPIVYQMHEELKPYILKDPYVKNNIEQFYEEPAFILSFIKDRTAYIKNNLLTF
>NZ_CP018874.1|WP_064471480.1|1387067_1388186_+|hypothetical-protein
MENYYYYYGQNQGQDSNPNRKRSHSKNANRPDKGYSSQFKPLKGRMVTVYRGGPESKTGYLLDVQSDYLILAVENDNNNNNDENNNEGNSNQNNQSNQNNQNNQQEYTVVYYHLSHVKSITEDAMSNSAQTFTGFDNEGTLELYRGKTFASTLSLLKSKYVQINQGGPEKKAGQLLDVLGSSESAYLVLLSEDDGIVYINVEHVKSISEYQNNNNNNNNNNIQMNNQFATNQEPTYMKSKNFNNLFTHLSHKWVSINGGGPEAVEGVLVQSRNGTFTLVQDNQVLRLQPRHVKTICVGAKGSFKQNNNQDDEQKEENTNTEDGGSTEGVPEGRTGRSRRTGSHSSGKSRRTGSHSSASREQVIQTKNYRWKA
>NZ_CP018874.1|WP_029325135.1|1388250_1388913_+|hypothetical-protein
MSINRYINKIVEVDISGKTNFIGRLVDLGLDVMILYNGHDYLYIPLLHMHRLREVSEEDYTVLREIEENLIEESQRISYRNILQQAKGKFIEIYVTGGKSLHGYITSVLNDYLVFYSPVYKNVFVSLHHLKWLTPYSNELTPYSLSDKELPVRPASAPFVRNFEEQLKKYENQLVVLDLGDQSEKIGVLKEVSNNIVELITANGESMYWKLAHVKSVHLP
>NZ_CP018874.1|WP_013056122.1|1389269_1390415_+|PLP-dependent-transferase
MKIETLLVRSGVGRDPSTGSITTPIYQASTFAHPALGQSTGFDYARTANPTRTALEEAIAALEKGEVGVAFASGMAGVMAVLALFKNGDHLIVSEDLYGGTYRVLNEIFSEQGITVSYVNTAHLEQVKDALRPNTKALFIETPTNPMMHVTDLPEAIALAKQHDLLTIVDNTFMSPYYQRPLELGADIVIHSASKYIGGHNDVVAGLVVARCSSLGEKIRFYQNAAGAILGPQDSWLLLRGVKTLALRMEKHNENALKIANWLTAHDLVEKVYYPGLETHPGYEIMKKQATGFGGMISFAVSHPDIVSTLLENVKVITFAESLGGVESLMTFPARQTHADIPEEIRNRVGVTNCLLRLSVGIEHADDLIKDLKEAFDAYQQ
>NZ_CP018874.1|WP_013056123.1|1390398_1391580_+|PLP-dependent-transferase
MHTNNNKHRFGTNLIHANTGIDGHFGAVNVPIYQVSTFNQEDETNNGRYDYSRSGNPTREALENTIAQLENGYAGFAFSSGMAAISSVLSIFESGDEILVSHDTYGGTYRVLTRLFSKFGIKTTFVDTTKVEKVEEAITKDTRAIYIESPSNPFLQVTDIKAVASLAKERNLLTIVDNTFLTPYLQQPIDLGVNIVIHSATKYISGHSDVIGGLVVVSDEKLAEEVKFVQNAFGAILGPQDCFLLLRGIKTLKVRLDQQLKTALQFAKWLEEQSLVSCVYYPGLESHPDHKLISEQANGYGAMISFQVQDEKVARHILQGVKLASIGVSLGAVESILTHPATMSHASIPKEVREEKGITDSLLRLSVGLEEFEDLKQDFDAVFQSLEEKALIK
>NZ_CP018874.1|WP_078081621.1|1391615_1391882_-|hypothetical-protein
MTSEHLLAAYQTLWLNRSFASKQAMTSEDQLHEAIMKDLKDEMTHPRVRQTPHVKYHLGIKRILNSSLSSDEKVALTSLYTNLLDSCI
>NZ_CP018874.1|WP_013056125.1|1391944_1392604_-|SIMPL-domain-containing-protein
MQHSYFPYEPTQQLRVDTQNREIKVIGEGSVSAVPNEISMTIGTRTENRDVQEALKENSAVSNTLLQEIKNLGINDQQIETASFTINPKYDYSDGKSTLTGYEVQHLFRVRVQDVKQAGDVYNATFSSGANVAQDLQFHVTNDDKYEQEAISKALLNAKEKAFTIANTLQLPINQIPILIEEGSVYQSSGSSPKLLAASPPIQAQSLTVSASVKVTYTY
>NZ_CP018874.1|WP_013056128.1|1394606_1395152_-|YhcN/YlaJ-family-sporulation-lipoprotein
MKKSFLFVVGCMTTLSLFGCSTADQGKDGVIDDDTVRNVTYENGNNKTKMNDVNDTQDVQRNEKEQYNQSGGMRVADVAADRIVALKNVKDANVIVTDHTAYVAAVLDDNKEGNLTKDMEHKIAHEVRKADGSVHRVFVSTNPDFVNRMNGYVDKLQTGKPVSGLFNEFSEVVRRVFPNSR
>NZ_CP018874.1|WP_013056129.1|1395263_1395431_+|hypothetical-protein
MSGIQQSIFVLHTKEENHEETTTFALTSEEAKLLFETLQNKRKEIIDAHIDNMLT
>NZ_CP018874.1|WP_013056130.1|1395717_1395921_+|cold-shock-protein
MATTGTVKWFNSEKGFGFIEVPGENDVFVHFSAIQSEGFKTLEEGQKVEFEIVEGQRGPQAENVVKL

Crispr_ID: NZ_CP018874_5

• CRISPR_ID: NZ_CP018874_5
• CRISPR_location: 2069363-2069452
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018874_5

Consensus_repeat	Method
TCAAATGCAGCCGCCAAGCGGTTC	CRISPRCasFinder

spacers of NZ_CP018874_5

>5.1|2069387|42|NZ_CP018874|CRISPRCasFinder
ATCGAACGGCGGTCAAATGCCGGGCGGTTCGTCCAATAATGG

CRISPR arrays and Neighbor proteins around NZ_CP018874_5

CRISPR arrays

The CRISPR arrays of NZ_CP018874_5

>merge|NZ_CP018874|5|2069363-2069452|CRISPRCasFinder
TCAAATGCAGCCGCCAAGCGGTTCATCGAACGGCGGTCAAATGCCGGGCGGTTCGTCCAATAATGGTCAAATGCAGCCGCCAAGCGGTTC

>NZ_CP018874|5|3|2069363-2069452|CRISPRCasFinder
TCAAATGCAGCCGCCAAGCGGTTC	ATCGAACGGCGGTCAAATGCCGGGCGGTTCGTCCAATAATGG
TCAAATGCAGCCGCCAAGCGGTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018874.1|WP_078081759.1|2077688_2078555_+|sulfate-ABC-transporter-permease-subunit-CysW	unknown	unknown	gnl|CDD|226665
NZ_CP018874.1|WP_078081755.1|2060404_2060671_-|diaminopimelate-epimerase	unknown	unknown	unknown
NZ_CP018874.1|WP_013056821.1|2071308_2072196_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl|CDD|224131
NZ_CP018874.1|WP_013056822.1|2072340_2073015_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP018874.1|WP_078081754.1|2059802_2060402_+|DUF3298-and-DUF4163-domain-containing-protein	unknown	unknown	gnl|CDD|378702
NZ_CP018874.1|WP_029321460.1|2060843_2062268_+|phospholipase-D-family-protein	unknown	unknown	gnl|CDD|197210
NZ_CP018874.1|WP_013056813.1|2063944_2064349_+|CidA/LrgA-family-holin-like-protein	unknown	unknown	gnl|CDD|167253
NZ_CP018874.1|WP_013056824.1|2074768_2074933_+|YezD-family-protein	unknown	unknown	gnl|CDD|378371
NZ_CP018874.1|WP_013056826.1|2075680_2076745_+|sulfate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|224529
NZ_CP018874.1|WP_013056817.1|2066852_2067425_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NZ_CP018874.1|WP_013056825.1|2075275_2075428_+|Fur-regulated-basic-protein-FbpA	unknown	unknown	gnl|CDD|315692
NZ_CP018874.1|WP_013082952.1|2076839_2077676_+|sulfate-ABC-transporter-permease-subunit-CysT	unknown	unknown	gnl|CDD|131194
NZ_CP018874.1|WP_013056814.1|2064318_2065011_+|LrgB-family-protein	unknown	unknown	gnl|CDD|377236
NZ_CP018874.1|WP_078081758.1|2073016_2074396_+|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NZ_CP018874.1|WP_029321467.1|2066307_2066784_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013056815.1|2065281_2066154_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132912
NZ_CP018874.1|WP_029321473.1|2069949_2070915_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133030
NZ_CP018874.1|WP_013056820.1|2070907_2071312_+|GtrA-family-protein	unknown	unknown	gnl|CDD|377229
NZ_CP018874.1|WP_029321464.1|2063319_2063751_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP018874.1|WP_057274117.1|2062382_2062895_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|226489

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018874.1|WP_078081759.1|2077688_2078555_+|sulfate-ABC-transporter-permease-subunit-CysW	gnl|CDD|226665	COG4208, CysW, ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism].	1.40944e-146
NZ_CP018874.1|WP_013056821.1|2071308_2072196_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl|CDD|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	2.50371e-163
NZ_CP018874.1|WP_013056822.1|2072340_2073015_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.02357e-78
NZ_CP018874.1|WP_078081754.1|2059802_2060402_+|DUF3298-and-DUF4163-domain-containing-protein	gnl|CDD|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	3.26412e-15
NZ_CP018874.1|WP_029321460.1|2060843_2062268_+|phospholipase-D-family-protein	gnl|CDD|197210	cd09111, PLDc_ymdC_like_1, Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins. Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins. In Escherichia coli, there are two genes, f413 (ybhO) and o493 (ymdC), which are homologous to gene cls that encodes the Escherichia coli cardiolipin (CL) synthase. The prototype of this subfamily is an uncharacterized protein ymdC specified by the o493 (ymdC) gene. Although the functional characterization of ymdC and similar proteins remains unknown, members of this subfamily show high sequence homology to bacterial CL synthases, which catalyze the reversible phosphatidyl group transfer between two phosphatidylglycerol molecules to form CL and glycerol. Moreover, ymdC and its similar proteins contain two HKD motifs (H-x-K-x(4)-D, where x represents any amino acid residue) that characteriszes the phospholipase D (PLD) superfamily. The two motifs may be part of the active site and may be involved in phosphatidyl group transfer.	9.1222e-62
NZ_CP018874.1|WP_013056813.1|2063944_2064349_+|CidA/LrgA-family-holin-like-protein	gnl|CDD|167253	PRK01658, PRK01658, CidA/LrgA family holin-like protein.	6.08572e-35
NZ_CP018874.1|WP_013056824.1|2074768_2074933_+|YezD-family-protein	gnl|CDD|378371	pfam10055, DUF2292, Uncharacterized small protein (DUF2292). Members of this family of hypothetical bacterial proteins have no known function.	2.45935e-11
NZ_CP018874.1|WP_013056826.1|2075680_2076745_+|sulfate-ABC-transporter-substrate-binding-protein	gnl|CDD|224529	COG1613, Sbp, ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism].	0
NZ_CP018874.1|WP_013056817.1|2066852_2067425_-|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.2175e-41
NZ_CP018874.1|WP_013056825.1|2075275_2075428_+|Fur-regulated-basic-protein-FbpA	gnl|CDD|315692	pfam13076, Fur_reg_FbpA, Fur-regulated basic protein A. This family of proteins is regulated by the ferric uptake regulator protein Fur. This family does not regulate the lutABC operon encoding iron sulfur-containing enzymes necessary for growth on lactate.	9.42134e-08
NZ_CP018874.1|WP_013082952.1|2076839_2077676_+|sulfate-ABC-transporter-permease-subunit-CysT	gnl|CDD|131194	TIGR02139, permease_CysT, sulfate ABC transporter, permease protein CysT. This model represents CysT, one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysW (TIGR02140). The sulfate transporter has been described in E. coli as transporting sulfate, thiosulfate, selenate, and selenite. Sulfate transporters may also transport molybdate ion if a specific molybdate transporter is not present. [Transport and binding proteins, Anions].	3.2288e-143
NZ_CP018874.1|WP_013056814.1|2064318_2065011_+|LrgB-family-protein	gnl|CDD|377236	pfam04172, LrgB, LrgB-like family. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance.	1.63516e-76
NZ_CP018874.1|WP_078081758.1|2073016_2074396_+|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.87351e-61
NZ_CP018874.1|WP_013056815.1|2065281_2066154_+|STAS-domain-containing-protein	gnl|CDD|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	9.66308e-41
NZ_CP018874.1|WP_029321473.1|2069949_2070915_+|glycosyltransferase-family-2-protein	gnl|CDD|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	2.50985e-99
NZ_CP018874.1|WP_013056820.1|2070907_2071312_+|GtrA-family-protein	gnl|CDD|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.55329e-22
NZ_CP018874.1|WP_029321464.1|2063319_2063751_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.75984e-17
NZ_CP018874.1|WP_057274117.1|2062382_2062895_+|GNAT-family-N-acetyltransferase	gnl|CDD|226489	COG3981, COG3981, Predicted acetyltransferase [General function prediction only].	2.86059e-52

Protein sequences

>NZ_CP018874.1|WP_013056817.1|2066852_2067425_-|GNAT-family-N-acetyltransferase
MIQVKDIYGNLPTLETERLRLRKVTKKDVRDMFEYASNEKVSRYVNWEKHRKLQDTKEFVSFVLKQYSNQSISPWAMEIKALKKCIGTIDFVTWNPTHRIAEIGYAISEAYWNKGFVTEAAEKVIAFGFEEMDLVRIQARCFIENAASEKVMKKIGMSYEGTIRKAMFIKGAHQDLKLYSILREEYTRNA
>NZ_CP018874.1|WP_029321467.1|2066307_2066784_-|hypothetical-protein
MLEQAIQHLDLSAHGLWFPITASLCLFILAFVLFKRKLTWRDFYITFSVVGFVGWLCDVIITRVFNVIDLGDPKVTGLGDILSYTFIPPSLSVLFLTYLTAKNKWVLSLLFCAGSLLIEYGMIKSGYMHLNGWFFIYSIVVYLLVYAFVLPWHIAFIK
>NZ_CP018874.1|WP_013056815.1|2065281_2066154_+|STAS-domain-containing-protein
MKEELVYIGKKIIEHKYNLSEKLAERLDATHPLSTEELKEKKILKWRVSIMEYFGRVLFEEQEAVLKLVKEWALATGKYAVEKNIPLEKALGTLPIYRSVIWDVFTRELEEHQFAAITMLHVSERIDPLLDTVTCIFGQIYDEHNRYMMNLAYTSLEELSVPLVPVTKGIAIMPIIGEIDTHRSQVIMETCLKKGTSLQLAYLILDISGVVIIDTMVADNLFKIHQALKLVGVEAIITGIRPEIAQTVVKLGINFNQIKTEANLEAALLKIGFRRSEEHRPTHLSSRRIK
>NZ_CP018874.1|WP_013056814.1|2064318_2065011_+|LrgB-family-protein
MQEFFIAVFIIVATVALYLVMAKVYVRFSYPILIPVLTTTIFVILLLLTFHVSYDEYMIGGKWINSLLGPAVVALAYPLYKQREMLVKYSVPIIGGVFVGLFAGMISGLVFAEVFGIDRSLILSIIPKSITTPVAIQIATGLGGVPSMTVVFVMIAGFSGVILGPLLLKWIRIKSSLGKGIALGSASHALGTSKAFEYGELTVSMSSVSMTLSAVLGSVFGPIVVWLFQV
>NZ_CP018874.1|WP_013056813.1|2063944_2064349_+|CidA/LrgA-family-holin-like-protein
MKVIRIILQIAILYAFSMIGEAVHHMLHLPIPGSIIGLILMLICLMCKIVPIKVIEDGASFLLSFLPLLFIPAMAGVMNYPSLLSSSGAVLFLIIVLSTIVTMAAAGIASQLLEKKANKRKEKQQCKNSLSRSL
>NZ_CP018874.1|WP_029321464.1|2063319_2063751_-|MarR-family-transcriptional-regulator
MQEKNSIELIEYELTTFIRRAVYLDNSENKIGNLERSAYLLLRQLDEFGPARVKELAEAFKLDISTLSRQAAALENKQLISRSSDPSDGRVSLFDITARGKRMLQSDKQMRLERYHSMLKKWSSEEKELFGKLLMRMNDAFID
>NZ_CP018874.1|WP_057274117.1|2062382_2062895_+|GNAT-family-N-acetyltransferase
MKPDAAYKKAYMSFYHEWKASGEKMIPWVIAKDPTHFEEMIQELINAEKGIGLKKGYVPDSTYWLMHNERVIGVVNIRHELSELLRNSGGHIGYGIRPSERKKGYAKLLLKLSLQEIRKLGVQRALVVCDDWNIASRQTILANGGIQDEDYIEENGAVVQRFWIHTDKIV
>NZ_CP018874.1|WP_029321460.1|2060843_2062268_+|phospholipase-D-family-protein
MIKIAFKGLLIILSLYILYVVIAAVVLFYVPLKTGEETTSIKPDSFFGHSESTDRVRLLEDGYEAGRVRIQMIQEAEKSIDIAYYSIGKGESTDLIMAALFKAADRGVYTRVLLDGIANGLRGNRRGVLYALASHPNIEVKYYEPFQLFKPWAWQNRMHDKIMIVDGQLGIIGGRNIGDKYLANKPPPDFVYDRDVFITNSKHKQDSVIVQMQNYINELWAHPYTKKAFYHLTQYQVDQGKRMKALLLQQYGKAKQVGETFATPKINWNASTVSTKCVSFIHNPIERFNKRPFMWKTLINLAEGANRSVLIQSPYVVPTNAMSKYTAIKKKRDVQWTLLTNSVTSTPNVLAFSGYISMRDTIMKTGVKLYEYQGPYSIHAKSVIYDQRLSAVGSFNLDSRSTFLNNESMVIIDSQKFAKELTMAMENKIDKSILVANHKRWIKSPDVQRKEEPVMKRTFLYALAKVTRFFKEFI
>NZ_CP018874.1|WP_078081755.1|2060404_2060671_-|diaminopimelate-epimerase
MEEYSFRFHITDSYPLHNENDKIEAVVRAKIKHADRGCLYEGYLRVHITKVGVFPVAKDIAEAISVRSLRQQLAAELKRYVRPHRNFL
>NZ_CP018874.1|WP_078081754.1|2059802_2060402_+|DUF3298-and-DUF4163-domain-containing-protein
MVTLPATVYSQQMVKKKLNAYYPVVHLTNQAVQHSMNSKILQRTNELIRQQGYGENPDTEETGYYELKTNERNVLSLTLVNFAYSGGAHGLTVVVPLTFNVLTGKTYQLKDLFKKDSNYVSILSKIVGEQIKERDIMVLGEYKGIKPDQDFYIADKSLVLFYQLYDLAPYVYGIPHFPISIYTIQDIIEDESPLGQMFG
>NZ_CP018874.1|WP_029321473.1|2069949_2070915_+|glycosyltransferase-family-2-protein
MSSIVKYSIVVPVYNEEEVIHETYRRLTEVMRSTKEAYELLFVNDGSKDRTAEIIKEYSEQDPAVVLLDFARNFGHQIAITAGMDYARGEAVVVIDADLQDPPELILEMIEKWKQGFDVVYAKRTKRKGETYFKKQTAAMFYRFLRAMTDIDIPLDTGDFRLLDRKVCDQMNSIQEKNRFVRGLVSWVGFKQIAVEYERDERLAGESKYPLKKMLKLSMDGITSFSYKPLKLASYAGVTLSGIGFIYLLVVMYLKLFTDSTITGWSSLIVIQLFFSGIILIILGMIGEYIGRIYDETKNRPLYIVREKYQLETREEVSLRD
>NZ_CP018874.1|WP_013056820.1|2070907_2071312_+|GtrA-family-protein
MTNKWISFIKFALVGVVNTLIDFVVYALLTTIGVNYILAQWISYSVGILNSYVMNRKWTFERKEKSSKREVISFVIVNLITLSLTSFLLTVLYNKWGIPLLISKLLITIASVGINFIGTKLFVFTTKKERGIHI
>NZ_CP018874.1|WP_013056821.1|2071308_2072196_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MTIKKAVIPVGGLGTRFLPATKAQPKEMLPIVDKPAVQYIVEEAVKSGIESIIFITGRNKKSIEDHFDKSIELEQMLEEKHKFDMLKEVQTISSMASIHYIRQKEPLGLGHAILCAEQFIGDEPFAVLLGDDIMTSEEPALKQMIQAYETTNQSVIGVQKVDVEEVSKYGIIQPKNKSGSLHEVSDLIEKPSIEQAPSTIAVMGRYILNPSIFSYLKTIERGVGNELQLTDALRVVCEKERLFALELEGQRFDIGDKIGYMKAMVEVALKRKDLRQTFLSYLEGIVEKERANNFS
>NZ_CP018874.1|WP_013056822.1|2072340_2073015_+|response-regulator-transcription-factor
MIQILVADDDQHIRELISLYLENQGFKIIKAADGEEAWAKMEEFRIDLAVVDIMMPFKDGWELTKEIKEYFDIPVLMVTARGESHDKLKGFDIGTDDYVVKPFDPQEMVARVKALLRRYRVEANNVIYMGNIKLDRTKLEMSAGETSEQLPLKEFELLFTLVSSPGKIFTRDQLIQLIWGYDYEGDERTVDVHIKRLRERLNHMKNVGMEIKTIRGLGYRAEGC
>NZ_CP018874.1|WP_078081758.1|2073016_2074396_+|HAMP-domain-containing-histidine-kinase
MKSIYVKLVLSFIITILLSVVITVVVTTFLSKQKLEMRLGQDMVKMGEDFIDLYGAEDSDKAARFLSNSSFIHFSFIIIDDQHEEKVLGQPGPPIPITPQEVDQVLDGKRYSNLNEEKGDRPQPNVVGLPFKENGRSYALFIQSHPQRQFSVIQDVQNIQLITILLVGIVLFAYVSTIIIKPIKRLSTAMKVVGQGEYNVQVEHATNDEIGLLTKNFNQMTKELNKIETMRQEFIASVSHEIQSPLTSIRGFSAALKDDIVSEDKKIQYLTIIEKESTRLSQLSSNLLKLASLDSEHQTLTLQQYRLDEQIRHVVMALEPQWTKKNIEIDLDLSNVQMEADKDLLEQVWLNLVTNAIKYTPENGLVKISIHQKNEEIDVEIKDNGIGIAEEDQKYIFESFYKVDKSRTLKGSGLGLAITKKIVRLHEGAIRVESKKEQGSIFTVTLPIQKNRTKKDSSV
>NZ_CP018874.1|WP_013056824.1|2074768_2074933_+|YezD-family-protein
MASITQEKLDYIVKLLTEINYGSVLITLHDGQITQVDSTEKNRFLAKSKVASHK
>NZ_CP018874.1|WP_013056825.1|2075275_2075428_+|Fur-regulated-basic-protein-FbpA
MENLLRAAVRQRKQYLIEELLKKGIYKKENHHLFELTLSDLEKEYQARSK
>NZ_CP018874.1|WP_013056826.1|2075680_2076745_+|sulfate-ABC-transporter-substrate-binding-protein
MKKKAVQFLMVLTALLVVLAGCGNGKSTETAGKDSSVSKNDSKKSVELLNVSYDPTRELYQEFNKSFASYWKDKTGQDVTIKQSHGGSGKQGRAVIDGLEADVVTLALAYDIDEIAQTRQLLNKDWEKELAHNSTPYTSTIVFLVRKGNPKGIKDWDDLTKKGTSVITPNPKTSGGARWNYLAAWAYAKNKYNGDNKKIEDFMSKLYGNVEVLDSGARGATTTFVERGIGDVLIAWENEAYLSLNELGKDKFEIVTPSLSILAEPPVAVVDKVAEKKGTTKVAKAYLKYLYTEKGQEIAAENYYRPRNEKVLEKHKDQFPSLNLVTIKDFGGWKKAQETHFNDGGTFDQIYQPK
>NZ_CP018874.1|WP_013082952.1|2076839_2077676_+|sulfate-ABC-transporter-permease-subunit-CysT
MSVLQRQKKKKSILPGFGLSLGFTMFYASILVLFPLAMIFLNTASMGWSDFIKTVTDSRVVASYKLSFGAAFAAGIINVIFGTIIAWVLVRYHFPGKRFIDGLVDLPFALPTAVAGIALTTLYVPKGWIGQLFTFKIAFTPIGIIIALTFIGLPFVVRMVQPVLQNFNAEIEEASASLGASRMQTFRKVIFPELVPAILTGFSLSFARALGEYGSVVFIAGNMPMKTEITPLIIMTKLEQYDYAGATAIASVMLVVSFFLLLLINIIQWWTNRKFVHS
>NZ_CP018874.1|WP_078081759.1|2077688_2078555_+|sulfate-ABC-transporter-permease-subunit-CysW
MTGHVPMQHAKTNVELNHSSLKEPKVVRWLLTFIALAFLALFLVLPLITIFMTAFQKGWETYLAAITNPDALAAIKLTLIVVLITVPLNAVFGVVAAWLITKFDFKGKNLLITLIDLPFAVSPVIAGLVFILLFGAQGLFGEWLFNQDIKIVFAIPGIILATLFVTLPFVAKELIPLMQAQGSAEEEASLTLGASGFKTFFLVTLPNIKWGLLYGIILCNARAIGEFGAVSVVSGHIRGMTNTMPLHIEILYNEYQFAAAFAVASLMSVLAIFTLIVKNIIEWKAKHI

Crispr_ID: NZ_CP018874_6

• CRISPR_ID: NZ_CP018874_6
• CRISPR_location: 3824973-3825067
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018874_6

Consensus_repeat	Method
CCTTGGCCCCCTCCTCCAGGTGG	CRISPRCasFinder

spacers of NZ_CP018874_6

>6.1|3824996|49|NZ_CP018874|CRISPRCasFinder
TGGCGGTGGAAACCCTTGACCTCCTCCTCCAGGTGGCGGTGGCGGAAAT

CRISPR arrays and Neighbor proteins around NZ_CP018874_6

CRISPR arrays

The CRISPR arrays of NZ_CP018874_6

>merge|NZ_CP018874|6|3824973-3825067|CRISPRCasFinder
CCTTGGCCCCCTCCTCCAGGTGGTGGCGGTGGAAACCCTTGACCTCCTCCTCCAGGTGGCGGTGGCGGAAATCCTTGGCCTCCTCCTCCAGGTGG

>NZ_CP018874|6|4|3824973-3825067|CRISPRCasFinder
CCTTGGCCCCCTCCTCCAGGTGG	TGGCGGTGGAAACCCTTGACCTCCTCCTCCAGGTGGCGGTGGCGGAAAT
CCTTGGCCTCCTCCTCCAGGTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018874.1|WP_013084668.1|3823167_3823665_-|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl|CDD|376324
NZ_CP018874.1|WP_029323930.1|3826569_3827736_+|rod-shape-determining-protein-RodA	unknown	unknown	gnl|CDD|274033
NZ_CP018874.1|WP_013058696.1|3814810_3815629_+|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl|CDD|176543
NZ_CP018874.1|WP_013058711.1|3829646_3830351_-|purine-nucleoside-phosphorylase	unknown	unknown	gnl|CDD|180275
NZ_CP018874.1|WP_013058704.1|3822302_3823130_-|PRD-domain-containing-protein	unknown	unknown	gnl|CDD|170086
NZ_CP018874.1|WP_029323933.1|3832181_3832952_-|sporulation-protein	unknown	unknown	gnl|CDD|369195
NZ_CP018874.1|WP_029323925.1|3820744_3822124_-|PTS-sucrose-transporter-subunit-IIBC	unknown	unknown	gnl|CDD|131051
NZ_CP018874.1|WP_013058717.1|3832938_3833775_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP018874.1|WP_013058712.1|3830545_3830698_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013058713.1|3830749_3831073_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013058698.1|3816344_3817187_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_CP018874.1|WP_013058701.1|3819420_3820239_-|membrane-protein-insertase-YidC	unknown	unknown	gnl|CDD|179508
NZ_CP018874.1|WP_013058697.1|3815656_3816343_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013058706.1|3823919_3824546_-|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl|CDD|224103
NZ_CP018874.1|WP_078082118.1|3817851_3819057_-|TolB-domain-containing-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013058714.1|3831319_3831946_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|239486
NZ_CP018874.1|WP_078082119.1|3833778_3834033_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018874.1|WP_013058710.1|3827978_3829427_-|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl|CDD|223732
NZ_CP018874.1|WP_013058699.1|3817306_3817816_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|372596
NZ_CP018874.1|WP_050691585.1|3825334_3825880_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018874.1|WP_013084668.1|3823167_3823665_-|PTS-glucose-transporter-subunit-IIA	gnl|CDD|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	2.28018e-69
NZ_CP018874.1|WP_029323930.1|3826569_3827736_+|rod-shape-determining-protein-RodA	gnl|CDD|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.21794e-108
NZ_CP018874.1|WP_013058696.1|3814810_3815629_+|glycerophosphoryl-diester-phosphodiesterase	gnl|CDD|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	2.0477e-97
NZ_CP018874.1|WP_013058711.1|3829646_3830351_-|purine-nucleoside-phosphorylase	gnl|CDD|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	1.12353e-162
NZ_CP018874.1|WP_013058704.1|3822302_3823130_-|PRD-domain-containing-protein	gnl|CDD|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	6.7835e-49
NZ_CP018874.1|WP_029323933.1|3832181_3832952_-|sporulation-protein	gnl|CDD|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	1.80055e-92
NZ_CP018874.1|WP_029323925.1|3820744_3822124_-|PTS-sucrose-transporter-subunit-IIBC	gnl|CDD|131051	TIGR01996, Includes:_Phosphotransferase_enzyme_IIB_component, PTS system, sucrose-specific IIBC component. This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).	0
NZ_CP018874.1|WP_013058717.1|3832938_3833775_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.30622e-48
NZ_CP018874.1|WP_013058698.1|3816344_3817187_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.45239e-46
NZ_CP018874.1|WP_013058701.1|3819420_3820239_-|membrane-protein-insertase-YidC	gnl|CDD|179508	PRK02944, PRK02944, YidC family membrane integrase SpoIIIJ.	6.90293e-106
NZ_CP018874.1|WP_013058710.1|3827978_3829427_-|SulP-family-inorganic-anion-transporter	gnl|CDD|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	2.1468e-137
NZ_CP018874.1|WP_013058699.1|3817306_3817816_-|GNAT-family-N-acetyltransferase	gnl|CDD|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	1.04918e-15
NZ_CP018874.1|WP_013058706.1|3823919_3824546_-|FMN-dependent-NADH-azoreductase	gnl|CDD|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	1.74036e-85
NZ_CP018874.1|WP_013058714.1|3831319_3831946_-|phosphatase-PAP2-family-protein	gnl|CDD|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	2.5199e-46

Protein sequences

>NZ_CP018874.1|WP_013058706.1|3823919_3824546_-|FMN-dependent-NADH-azoreductase
MANVLYVKVNPQVDEASFSTRLAQVFLDEYKTANPTDTVTTLDLYKETVPFIDGDVLAAWGKAGAGEELSTVELEKVTRMGELVEQFLQADKVIFSAPMWNLSFPPLMKAYIDNILIAGKTFKYTENGPVGLASDKKVVLLEARGGVYSEGPAAELEFTQSYLRTVMSFIGVQDFQLVVAEGMAYTPAEADNILAKASEKAKEVASTF
>NZ_CP018874.1|WP_013084668.1|3823167_3823665_-|PTS-glucose-transporter-subunit-IIA
MFKKLFGNKTKSKETTVLAPLSGNILPISEVPDPVFAQKMMGDGFAIEPSEGQVVSPVAGEVVQLFHTKHAVGLKTEAGTEVLIHIGLETVAMEGEGFEAHVAQGDKVSVGTPLITFDLALIQEKAKSIITPIVITNSDASESFEILAQGTVQKGETACAKVTMK
>NZ_CP018874.1|WP_013058704.1|3822302_3823130_-|PRD-domain-containing-protein
MKILKVLNNNAVVFKEGGVEKIAMGPGIAFQKGKNDLINAAKVEKVFVMKEEQEKFQELLKNLPEEHIQVAEEIISYAEQQLSATLSHHVHIALSDHLSFAVERIARGISIQNKLLNEIKSLYQPEYAIGVWALQHIKKRLDITMPVDEAGYIALHIHTAKLNSPGMQQLMMNTTIINEMVTIIKKELNTEIDENSMSYQRLLTHLRFALNRLAQNEPFHEMDEEMLDVLKVKYKKSYQCAETIKQFVKDEYEINFPEAELGYITLHICRIEQRI
>NZ_CP018874.1|WP_029323925.1|3820744_3822124_-|PTS-sucrose-transporter-subunit-IIBC
MDVKEIAKKLVPLLGGKENIASAQHCATRLRLVIRDESKIDQKGLDEIEDVKGAFSNSGQFQIIFGTGLVNKIHAAFVKELGADEAAAPADHQKEMKKKMNPFARFARMLSNIFVPIIPAIVASGLLMGLLGMMKAFHWVSKDSALFVLLDMFSGAAFIILPILIGFSAAKEFGSNPYLGAVIGGILTHPMLLNPWTLADAKPEYMDLFGLSIPLIGYQGTVVPILLAIYVMSKIEKGLRKIVPNSVDLLVTPFLTVIITGFVSLVFIGPFGRYIGDLISISLQSLYDVAGVFAGILFGGLYSTIVLTGLQHSFHAIEAGLLANPKIGVNFLLPIWACANVAQGGAGLAVYFKTKNAKTKKIAIPAAISSFLGITEPIIFGVNLRLRKPFIAAAIGGAAGGGYVVLMHVVANAYGLTGIPMMAIAAPLGMSNLIHYIIGMIISVGVAFGVTWFMKLKED
>NZ_CP018874.1|WP_013058701.1|3819420_3820239_-|membrane-protein-insertase-YidC
MKRNKKLLLLGLMGALLLALAGCSSTKTPVTATSGGFWDHYFVYPLSMALTKIAEWAGGSYGLSIIIATVIIRLVLLPLILKQQKSTMAMQALRPEMEKIQKKYAGKKDPETQQKQQKEMMQLYQTHKINPVGGCLPIFIQMPIIIAFYNAIARTHEIAQHSFLWVSLGKPDPYFILPVVAAITTFLQIRVSMTDEIQPPMKMMMNIMPIFILVAGISLPSALALYWVIGNLFGIGQGYYLKKRMSLLKEKDAANNTAQAKTKPSPKSKSKS
>NZ_CP018874.1|WP_078082118.1|3817851_3819057_-|TolB-domain-containing-protein
MVKKIALCLLFLMLFPMQINAANTVKVSFIRQGNLWVYDNGTERQLSYARHASMPQWSSHGDIVAYAENDSLMIAPLKGKPLLVEHDVTHYQWSPVAEELAYISNGILVYYNVKTHEKKRVAVGVDQFSWFPEGDRFLITSAAALAPTGWGPVKLYTVSKYAGLDVKKVEAFTTLPAENDSFFAYTTSSFKWSPNGQWISFIAIPTASMSADANKLCIITKEGKAFQVVGDMLNVPNWFKWSNEESVLAFINGEGRFATENKKFTLKEMPVFKEHVFTPKGFADWDFTWTEKDNIIISRVPEAGWSNDEKKRPLPFLYSMNVKTNKQSQFTFPQKGLGDYAPVYHKATNQTMWIRTNRKQANLLTRVKDTKNDKVLISGLDMPENYYELYRWNEVFSVYNP
>NZ_CP018874.1|WP_013058699.1|3817306_3817816_-|GNAT-family-N-acetyltransferase
MNIRLLVKEDADAYFELRLRALKDHPESFILSYEEEYEKEIADIRNYFPSSQSEFVVGAFIEKQLVGIVGFQQQKPLKVQHKGDIWGMYVAPEARGKGLGKKLLKTAVEQAFSKTNVLQIYLAVAAKNEGAKVLYKSLGFTSYAYEKRALQVDGEFIDEEHMVLCMKSL
>NZ_CP018874.1|WP_013058698.1|3816344_3817187_-|ATP-binding-cassette-domain-containing-protein
MEKLIELKNVAKVYKKHTVLENIHTTLYKGETVAIVGKNGAGKSTFLKLIGGLSKPTKGTIHLHKETGTPGFVVEQFPQELRFTLAGYLQHMGRIQGLSKKKRSSRIEELLETFEMVEFRHEEIISFSKGMKQKVNMMQALLSSSKLLLLDEPLSGLDARAQLEVERIFTKLKERGMTIVFTCHEERLIHAVADRVITIGSQRILKNERVQLIEHLTVIEANVILNKPLRLLKEKCTKIEQHGNYWIFYIDKKYVNEFLAELLAVQAEVVKLYHMEREEI
>NZ_CP018874.1|WP_013058697.1|3815656_3816343_-|hypothetical-protein
MGALIRYHFITYIKSYRYIPPLALYIISLCMNYTYRPNPVLDSFFNTALFLFFLTTWFTMSLFHAEDSSQEVITKLHVGKKSKYFMSKLITCMLLFTFLSAVSIAYPVLLDMFEVDISTKQMVFGFIIHWTFSLLGMSIGLVFTRDVVREGSLSWFGPLFILIVTLAAAGVSFPYQGGGLLLYVLPPVSAIIQFINEGLNKFLVFGWALLYAIALISLYLWRANRRDV
>NZ_CP018874.1|WP_013058696.1|3814810_3815629_+|glycerophosphoryl-diester-phosphodiesterase
MRRKWWFVSSLTLCLCGIFMFIHTQAASIQAEKVAIIAHRGASGYEPEHTMQSYLAAVQQKADYIELDLHMSKDQQLVAIHDYKVDRTTNGTGYVKQYTVKQLQRLNAGKGNKKAVIPTLEEIFRTFGNRTNYYIETKSPHEYPGMEKELLTLMAKYNIHTNHVIVQSFSPESLKTVHRYRPTMKLIQLIRSKQTNMLTDQQFRQIKTYANGIGPNANTLTKPYVQKARSYDLDVHPYTVNDEKQMRTLIEWGVTGMFTNYPDRLYNVLHNK
>NZ_CP018874.1|WP_050691585.1|3825334_3825880_-|hypothetical-protein
MIIGASVTAFLLLWWTIFYSGRYYHYVSEPVGKRISLHVGIHVTLVVGVNACLWLEQPLLFSSILAGCAGLGAGWFVGIPFSVKSILSGIMGGIGTGVSFYISMSMWMDQFNWLSFLLIGTSVIFSGSSLFQVLKSIPSFEKVLVKMWVQHPFLIAPILITVFWLYNFIEKYFPQADPTRK
>NZ_CP018874.1|WP_029323930.1|3826569_3827736_+|rod-shape-determining-protein-RodA
MGENQRNVSRFDWNLAFLIFLLFCVSVVAIHSAEKIGQYDKNFVAQQVVFYIIGMVIIGFIMRFDSDQLQKLTWVFYGFGNFLLLLLLVAPSSIAREINGAKSWFTLPGFSLQPSEFMKVFLIITLSTVIVKHNEKYRIRTVREDFLLLGKLGAVLALPLLLIMQQPDLGTALVFLAITIGLVFVSGVSWKIIAPAFLGITAVGSVILGLVVYAPNLLEKYLGVKQYQFGRIYSWLDPESYSSGEGYHLKKSLDAIGSGMVNGKGIGNGVVYLPEGQTDFIFAVIGEEFGFIGASIVISLFFVLVYYLIKLGLETKNEFNSYLCVGVISMLTFHVFQNIGMTIQVLPITGIPLPFISYGGSSLMGNMFAMGLMFGISWHHKRYMFGND
>NZ_CP018874.1|WP_013058710.1|3827978_3829427_-|SulP-family-inorganic-anion-transporter
MMASIKQQWFSNVRADILSGMTVALALIPEALAFSIIAGVDPMVGLYASFCMAIVIAFTGGRPAMISAATGAMSLLMIDLVKDHGIEYLFAATVLTGIIQILLGVLKVGRFLSFLPQTVMIGFVNALGILIFTAQLPHFQGANWMMYAMVAGTLLIVYLFPLMTKAIPSPLVAIVLMTIVAIVFHLDLKTVGDMGNITRSLPVLHFPKVDLSVETLLIILPYSLPLAIVGLLESMLTATVLDEITDTPSNKNKEARGQGIANIVTGFFGGMAGCAMIGQSMINVKSGGRGRLSTLVAGVFLLFLIMVLGDVVKQIPMAALVGVMFMVAAGTFDWQSLKDLTKYPLSDAIVMVVTVVIVLFTHNLALGVMVGIVLSTIVFGWKMAKIKTTSQTEGNMKQYRVSGQLFFATISFFMDEFQYETDPDTIIIDFSSSHIWDQSAVIGISKIIDKYERLNKKVIVKGLNEDSKKIVRQIGITSLSNK
>NZ_CP018874.1|WP_013058711.1|3829646_3830351_-|purine-nucleoside-phosphorylase
MSVHIGAKQGDIAETILLPGDPLRAKYIAETFLEDVTCYNEVRGMLGFTGTYKGKRVSVQGTGMGVPSIAIYVNELMNEYGVQNLIRVGTCGAIQKDVKVRDVILAMSSSSDSQMNRVKFGPIDYAPTANFDLLKRAYDAGVEKGLQLKVGSVFTSDQFYNEDGQLEKLAAHGVLAVEMETTALYTLAAKYGRNALSVLTVSDHIFTGEETTSEERQTTFNDMIVVALEAAINE
>NZ_CP018874.1|WP_013058712.1|3830545_3830698_+|hypothetical-protein
MGKKHRNRINSPKKNNHIPKEAIIAEHEAHGDEYSATNRKNGPGHHTRDY
>NZ_CP018874.1|WP_013058713.1|3830749_3831073_-|hypothetical-protein
MLSVWTTIKKQFNISTEYDVTIMQTEEKGEKRGYKPVHRLTITAFDHQDAATQVFQMFNIADNLPKDCDARFISTGDILLIDEGTRGKYYYKLWTDGWQKVNRLHVR
>NZ_CP018874.1|WP_013058714.1|3831319_3831946_-|phosphatase-PAP2-family-protein
MVNRTTKYSLFIVSLLAFFLLILFTFNTPWVKQLDFNVLHTIEGWRTDTLTPIIIFITTVGSWYVTAPIWFAIIVFLLYKRKGLLALYITLVFWGVRALNWGLKEIFARPRPDWSQVVPASHYSFPSGHAMNSMAFYSGVLLLIWMYTRSRAVKTAAACVIAIVILLIGFSRLYLGVHFLTDILAGYCLGLAWSLGVYLLSKRLYNQK
>NZ_CP018874.1|WP_029323933.1|3832181_3832952_-|sporulation-protein
MALFNKALARIGIGAARVDAKLVNDEFRAGEKIEGIVEVYGGNVEQKIDSIYLRLFTTYVKERDDKKYKQDIELNTFKINDPFTIQPAETKSIPFTFQLPDDTPVTLGRTRVWVATSLDIKDAVDPSDIDHVKVLPNLMVTSAIEAMEQLGFRLRQVECEEAPRRMRKRLPFVQEFEFVPSGGLYAGKVDEIEIIVQPSGLHDYDLFIEVDRRARGFGGFLSEMLDADESLVHVHVSEKEIPQLKNILTNIISRYS
>NZ_CP018874.1|WP_013058717.1|3832938_3833775_-|serine/threonine-protein-kinase
MMKNRMFKHLHRWLVDRPFKKGKVICGRYEIIDVLGMGSYGITYVANDIVQQKEVVVKQLRKTKQRTSQGLKSYHYEAKLLSQLNHPQIPSLYEAIETDEGCFLVMELIQGKTFEGLIFEEKCVYTEEQALDILLNILDVVSAIHEQGIIHRDLRIPNIIDVNGTIYVIDFGLARFLGDHEETSTLIEEQQFMRQTSAASDIYALGHFLLFLLYSGYEPTEKQERSWEQELSLSTPIKIIIQKMLRADESYESIKSLQKDIYDYINSKNSGRGKYGAI
>NZ_CP018874.1|WP_078082119.1|3833778_3834033_-|hypothetical-protein
MFRKIFESLTGSKHRRYSSSDRHYRRPRHYSSSDQHYRRPRHHSSSSDYKRSKYYDSHSHSKYGHHHYKRKRKSGSFFSSFFSS

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP018874_3	3.1|1182157|30|NZ_CP018874|CRT	1182157-1182186	30	NZ_CP018874.1	1182121-1182150	2	0.933
NZ_CP018874_3	3.1|1182157|30|NZ_CP018874|CRT	1182157-1182186	30	NZ_CP018874.1	1182133-1182162	2	0.933

1. spacer 3.1|1182157|30|NZ_CP018874|CRT matches to position: 1182121-1182150, mismatch: 2, identity: 0.933

acgagtagaacgacgagtagaacggcgggt	CRISPR spacer
acgagtagaacgacgagtagaacgacgagt	Protospacer
************************.**.**

2. spacer 3.1|1182157|30|NZ_CP018874|CRT matches to position: 1182133-1182162, mismatch: 2, identity: 0.933

acgagtagaacgacgagtagaacggcgggt	CRISPR spacer
acgagtagaacgacgagtagaacgacgagt	Protospacer
************************.**.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018874_4	4.3|1385314|30|NZ_CP018874|CRT	1385314-1385343	30	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	410212-410241	6	0.8
NZ_CP018874_4	4.3|1385314|30|NZ_CP018874|CRT	1385314-1385343	30	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	223902-223931	6	0.8
NZ_CP018874_4	4.3|1385314|30|NZ_CP018874|CRT	1385314-1385343	30	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	1051466-1051495	8	0.733
NZ_CP018874_4	4.5|1385398|30|NZ_CP018874|CRT	1385398-1385427	30	NZ_CP003710	Zymomonas mobilis subsp. mobilis NRRL B-12526 plasmid pZM1252601, complete sequence	14163-14192	8	0.733
NZ_CP018874_4	4.5|1385398|30|NZ_CP018874|CRT	1385398-1385427	30	NC_013785	Zymomonas mobilis subsp. mobilis ZM4 plasmid pZZM402, complete sequence	4954-4983	8	0.733
NZ_CP018874_4	4.5|1385398|30|NZ_CP018874|CRT	1385398-1385427	30	NZ_CP003716	Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023 plasmid pZM1402301, complete sequence	10677-10706	8	0.733
NZ_CP018874_3	3.1|1182157|30|NZ_CP018874|CRT	1182157-1182186	30	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	2455552-2455581	9	0.7
NZ_CP018874_4	4.3|1385314|30|NZ_CP018874|CRT	1385314-1385343	30	NZ_CP029234	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436d, complete sequence	11026-11055	9	0.7
NZ_CP018874_4	4.3|1385314|30|NZ_CP018874|CRT	1385314-1385343	30	NC_041927	Sphingobium phage Lacusarx, complete genome	78272-78301	9	0.7
NZ_CP018874_4	4.5|1385398|30|NZ_CP018874|CRT	1385398-1385427	30	NZ_CP016289	Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence	610556-610585	9	0.7
NZ_CP018874_4	4.5|1385398|30|NZ_CP018874|CRT	1385398-1385427	30	CP003957	Rhodococcus opacus PD630 plasmid 8, complete sequence	133227-133256	9	0.7

1. spacer 4.3|1385314|30|NZ_CP018874|CRT matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 6, identity: 0.8

gagcggcgagtagagcgacgagaagaacga	CRISPR spacer
gtacaccgagaagagcgccgagaagaacga	Protospacer
* .*. **** ****** ************

2. spacer 4.3|1385314|30|NZ_CP018874|CRT matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 6, identity: 0.8

gagcggcgagtagagcgacgagaagaacga	CRISPR spacer
gtacaccgagaagagcgccgagaagaacga	Protospacer
* .*. **** ****** ************

3. spacer 4.3|1385314|30|NZ_CP018874|CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.733

gagcggcgagtagagcgacgagaagaacga	CRISPR spacer
gcgcggcgagtacagcgacgagaactcgcg	Protospacer
* ********** ***********     .

4. spacer 4.5|1385398|30|NZ_CP018874|CRT matches to NZ_CP003710 (Zymomonas mobilis subsp. mobilis NRRL B-12526 plasmid pZM1252601, complete sequence) position: , mismatch: 8, identity: 0.733

gaacggcgagtagaacggcgagaagagcgg	CRISPR spacer
gtccggcgagtagaacgccgagaataattt	Protospacer
*  ************** ****** *..  

5. spacer 4.5|1385398|30|NZ_CP018874|CRT matches to NC_013785 (Zymomonas mobilis subsp. mobilis ZM4 plasmid pZZM402, complete sequence) position: , mismatch: 8, identity: 0.733

gaacggcgagtagaacggcgagaagagcgg	CRISPR spacer
gtccggcgagtagaacgccgagaataattt	Protospacer
*  ************** ****** *..  

6. spacer 4.5|1385398|30|NZ_CP018874|CRT matches to NZ_CP003716 (Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023 plasmid pZM1402301, complete sequence) position: , mismatch: 8, identity: 0.733

gaacggcgagtagaacggcgagaagagcgg	CRISPR spacer
gtccggcgagtagaacgccgagaataattt	Protospacer
*  ************** ****** *..  

7. spacer 3.1|1182157|30|NZ_CP018874|CRT matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 9, identity: 0.7

acgagtagaacgacgagtagaacggcgggt	CRISPR spacer
ccatagagaacgacgagaagaacggcgaaa	Protospacer
 *. . *********** *********.. 

8. spacer 4.3|1385314|30|NZ_CP018874|CRT matches to NZ_CP029234 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436d, complete sequence) position: , mismatch: 9, identity: 0.7

gagcggcgagtagagcgacgagaagaacga	CRISPR spacer
cttgcgcgcgtagagcgacgagatgaacag	Protospacer
     *** ************** ****..

9. spacer 4.3|1385314|30|NZ_CP018874|CRT matches to NC_041927 (Sphingobium phage Lacusarx, complete genome) position: , mismatch: 9, identity: 0.7

gagcggcgagtagagcgacgagaagaacga	CRISPR spacer
cggcggcgtgtagagcgaggagaagtgacc	Protospacer
 .****** ********* ****** .   

10. spacer 4.5|1385398|30|NZ_CP018874|CRT matches to NZ_CP016289 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

gaacggcgagtagaacggcgagaagagcgg	CRISPR spacer
tgcgggcgagaagagcggcgagaagaggtc	Protospacer
 .  ****** ***.************   

11. spacer 4.5|1385398|30|NZ_CP018874|CRT matches to CP003957 (Rhodococcus opacus PD630 plasmid 8, complete sequence) position: , mismatch: 9, identity: 0.7

gaacggcgagtagaacggcgagaagagcgg	CRISPR spacer
acacggcgagtatcacggcgagaaggaacc	Protospacer
. **********  ***********..   

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	251799 : 260061	8	Synechococcus_phage(50.0%)	NA	NA
DBSCAN-SWA_2	2166535 : 2193354	32	Bacillus_phage(22.22%)	integrase,portal,head,protease,capsid,terminase,tail	attL 2159893:2159908|attR 2199116:2199131
DBSCAN-SWA_3	4170566 : 4179866	8	Bacillus_phage(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP018874|251799:260061|DBSCAN-SWA
CATGATTGAACGTTATACAAGACCAGAAATGGCAGCTATTTGGACAGAAGAAAATAAATTTAAAGCTTGGTTAGAAGTTGAAATTCTAGCTTGCGAAGCATGGTCAGAATTAGGACATATTCCGAAAGAAGATGTGAAGTTAATTCGTCAAAATGCATCTTTTGATATTAACCGCATCAATGAAATTGAACTAGAAACGCGTCATGACGTAGTAGCTTTCACTCGTGCAGTATCTGAAACGCTTGGTGAAGAGCGCAAGTGGGTACACTACGGTTTGACTTCAACTGACGTAGTTGATACAGCTCTATCTTATTTATTAAAGCAAGCTAATGAAATCTTGCTAAGTGACGTAGAGCGCTTTGTAGAAGTACTAAAGGAAAAAGCTCAAGAACATAAGTATACGGTTATGATGGGACGTACGCACGGTGTACACGCTGAGCCAACGACATTTGGTTTGAAAATGGGATTATGGTACGAAGAAATGAAGCGTAACCTAGAGCGTTTAAAACGTGCAGCAGCTGAAGTGGAATTCGGTAAAATGTCAGGAGCAGTTGGAACGTTCGCTAACATCGATCCTTTCGTTGAAAAATACGTATGTGAGAAGTTAGGAATTTCACCAGCACCAATCTCTACGCAAACATTACAGCGTGACCGCCATGCACACTATATGTCAGTACTAGCGTTAATTGCGACATCTATTGAGAAATTTGCAGTAGAAGTTCGCGGTCTTCAAAAGAGTGAAACACGTGAGGTTGAAGAGTACTTTGCAAAAGGTCAAAAAGGTTCATCTGCAATGCCTCATAAACGTAATCCAATCGGTTCTGAGAACGTAACGGGACTTGCTCGCTTAATTCGCGGCTATATGGTTACAGCTTATGATAATGTACCGCTTTGGCATGAGCGTGACATCTCTCATTCATCGGCAGAGCGTGTCATCTTACCTGATGCAACGATTGCTTTAAATTACATGTTAAATCGTTTTGCAAACATTGTTAAAAACTTAACAGTATTCCCTGACAACATGAAGCGCAACATGGATCGTACACTAGGATTAATTTACTCACAGCGTGTACTGTTAACACTAATCAATAAAGGCATGGTACGCGAAGAAGCATACGACTTAGTACAGCCAAAAGCAATGGAAGCATGGGAAACGCAAGTTCCTTTCCGTTCTTTAATTGAAGGCGAAGAACGTATTACTCGCCACTTATCACCAGAAGAGATTGAAGATTGTTTCGATCATAAGCACCATTTAAAAAATGTAGATATGATTTTTGAACGTTTAGGTCTTTAATAAAAAAGGCAAGGCACGTCCTTGCCTTTATCTAAGAAAGTGTATCTGAATATTCTGTATGTAGAGGTGACAGCATGGAAAAGCAAGAGTTACTTTATGAAGGAAAAGCGAAAAAGATTTACGCTACTGATGAGCAAGATGTATTGTGGGTTGCTTACAAAAATGAAGCTACAGCATTCAACGGTCAGAAAAAAGCGGAGATTAGCGGAAAAGCACAGTTGAACAATCAAATTAGTAGTTTACTATTTTCAATGTTACATGAGCAAGGGATTACAACTCACTTTGTGAAGCAGCTTTCAGATCATGAACAAGCGGTTAAGAAAGTAGAAATTGTCCCGCTTGAAGTTGTTGTACGAAATGCTACAGCAGGAAGCCTGGCGAAGCGAATTGGCGTAGAAGAAGGTATTCGTTTTGAACAGCCAATCGTTGAACTTTACTACAAAGATGATGCGCTTGGTGATCCATTAATTCTTGCAGAACATGCGATTTTCCTTAAAGCTGCAACTCAAGAAGAGATTGATAGTTTAAAGGCACAAGCACTTCAAATTAACGAAATATTATCGAAATTTTTCAAAGATAAAGATATTTTCTTAGTGGATTTTAAATTAGAATTCGGCCGTACTTCTCAAGGCGACATTATTTTAGCGGATGAAATTTCACCTGACACTTGCCGCTTCTGGGACGTTCATACGAACGAAAAATTAGATAAAGATGTATTCCGCAGAGATTTAGGCGGTTTAACAGAAGCATACGAAAAAATCTTACAGCGAATCGGAGGATAACCCAACCATGTATAAAGTAAAAGTATTTGTCACATTAAGAGAAAGTGTATTAGACCCTCAAGGAGTAGCCGTTAAAAATTCATTGCACCGTATGTCTTATGAAGAAGTAGAAGAAGTACGCATCGGTAAATTTTTAGAGCTAACAATCGACAGCACAGATTCATTAGATGAACGCGTAAAAGAAATGTGTGAAAAGCTTTTAGTTAATACAGTAATTGAAGATTACCGTTACGAGGTTGAGGAGGTTGTCGTACAGTGAAATTTGCTGTAATTGTTTTTCCAGGATCAAACTGTGACGTCGATATGTATCATGCTATCAAAGATGAGCTTGGTGAAGAAGTAGATTACGTTTGGCACGATACAGAATCATTAGATCAATATGATGGTATCTTGCTTCCAGGTGGTTTCTCATATGGAGATTACCTTCGTTCAGGTGCTATCGCTCGCTTCTCAAATGTAATGGACGCTGTAAAAAAAGCAGCAAGCCAAGGAAAGCCAGTACTAGGTGTATGTAATGGATTCCAAATTTTATTAGAAGCAGGATTACTGCCAGGTGCTATGCGCCGTAATGAAAACTTAAAATTCATCTGTAAAACAGTGAATTTGAAAGTAGCTAATAACGAAACAATGTTTACAAATGCTTATGGCAAAGATGAAGTAATTGCTATTCCAGTGGCACACGGTGAAGGCAACTACTATTGTGATGAACACACGTTACAAAAATTGATTGAAAACAACCAGATTCTTTTCCAATACGCAGGTGATAATCCAAACGGAAGTCTTCAAGATATTGCAGGGATTACGAACGAAACAGGCAACGTATTAGGAATGATGCCTCACCCAGAAAGAGCGGTAAGCGATCTTTTAGGAAGCGCGGACGGACTTAAATTATTTCAATCAATCGTAAAGCAGTGGAGGGAACAAAATGTCGTTACTTCTTGAACCAAATGTAGAGCAAATTAAAGAACAAAAGTTATATCGAGACATGGGATTAACAGACGAAGAGTTTGCGAATGTAGAGCAACTGCTTGGTCGTACTCCTAATTATACAGAAACAGGCTTATTCTCTGTTATGTGGTCAGAGCACTGCAGTTATAAAAACTCTAAGCCTGTACTGAAAAAATTCCCTATCACGGGTGAAAAAGTATTACAAGGTCCTGGTGAAGGAGCTGGTATCGTTGATATTGGTGACAACCAAGCCGTTGTATTTAAAATCGAAAGTCATAACCATCCATCAGCGATTGAACCTTATCAAGGAGCAGCAACTGGTGTAGGTGGTATCATTCGTGACGTCTTTTCAATGGGAGCAAGACCGATTGCACTTTTAAACTCTTTGCGTTTTGGTGAATTAACTTCTCCAAAGGTTCGTCATTTGTTTGAGGAAGTAGTAGCGGGAATCGCAGGTTACGGTAACTGTGTAGGAATCCCAACAGTAGGCGGAGAAATTCAGTTTGAAGCTTCATATGAAGGAAATCCGCTTGTTAACGCTATGTGTGTGGGTTTAATTAATCACGAAGACATTCAAAAAGGTCAAGCTAAAGGCGTTGGCAACACGGTTATGTACGTAGGAGCAAAAACGGGCCGCGACGGTATTCACGGGGCAACATTCGCTTCTGAAGAACTATCTGATCAGTCAGATGAAAAGCGTCCTGCTGTACAAGTAGGAGATCCATTTATGGAAAAACTTCTTCTTGAAGCTTGCTTAGAACTTATCAAGTGTGACGCTTTAGTCGGTATTCAAGATATGGGTGCTGCGGGCTTAACAAGTTCTTCAGCAGAGATGGCAAGTAAAGCAGGTTCTGGTATTGAAATGAACCTTGATCTTGTACCTCAGCGTGAAACAGGTATGACACCATATGAAATGATGCTTTCAGAATCTCAAGAGCGCATGCTCATCGTTGTTGAAAAAGGCCGTGAAAATGAAATCGTAGAAATCGTAGAAAAATACGGATTAGAAGCTGTTTCAGTTGGTCACGTAACCGACGATAAGCGCCTTCGTTTAACTCATAACGGAGAAGTAGTCGCAGATGTTCCTGTAGATGCATTAGCAGAAGATGCACCGGTGTACCACAAGCCATCTCAAGAACCAGCATACTATCGTGAGTTCCAAGAGCAATCAGCATATGCTCCTACTGTTGAAAATCACAGTGATATGTTAGTAACACTTTTAAAACAGCCTACTATTGCAAACAAAGAGTGGGTTTACAACCAATATGACTATCAAGTACGTACAAACACAGTTGTATCTCCTGGATCTGACGCGGCGGTTGTTCGTGTACGTGATACAAATAAAGCATTAGCGATGACAACAGACTGTAACTCTCGCTATTTATACCTAGACCCAGAAGTAGGCGGCCGTATTGCAGTAGCAGAAGCTGCTCGTAACCTTGTATGTTCAGGTGCACAGCCTCTTGCAATTACAGACTGCTTAAACTTCGGTAACCCTGAAAAACCAGAAATCTTCTGGCAAATTGAAAAAGCAACAGACGGTATGAGCGACGCTTGCCGTGAGCTATCGACTCCGGTTATCGGCGGTAACGTATCTCTTTACAATGAAACAAAAGGTGAAGCAATTTACCCAACTCCTGTTATCGGAATGGTTGGTTTGATCGACGATATCAACCATATTACAACTCAATATGCGAAGCAAAAAGATGACTTAATCTATGTTATTGGTAAAGCTGAAGCAGAATTCGCAGGTACTGAGCTTCAAAAAGTACTAGAAAACGGTACGGTATTTGGGCATTCACCTAAATTAGATTTAGCAGTTGAAAAAACACGTCAAGATCAGCTTCTTCAAGCAATTCGTGAAGGTGCAGTTCAATCTGCTCACGATATTGCAGAAGGAGGATTCGCGGTAGCCCTAGCTGAAAAAGTGATGAACGGCAGCGGATTAGGTGTGGACGTAACGGTAGACGGCGAAGCAACAGCAGAGCTATTCAGTGAAACACAATCACGTTTTATCGTAACGGTTTCTCCAGAGAATAAAGAAAAATTCGAAATGCTTGTACAAGATGTAATATTAGTAGGACGCGTAACAGAAGACGCAACATTAACTGTTAAACATCAAGAAAATGTTCTTGTTCAATTATCAGTTGAAGAATTAACTACTGCTTGGAAAGGAGCGCTTCCATGCTTGCTGAAATCAAAGGCTTAAACGAAGAATGTGGCGTATTCGGTGTATGGGGACATGAAAATGCAAGCCAGATTGCTTATTACGGTTTGCATAGCTTGCAGCACCGCGGACAAGAAGGCGCTGGTATTGCTGTAACAGACGGAGAAAAAGTGACAGTAATGAAAGGCGTCGGTCTTGTTAACGAAGTATTTGGCCACGGAGAGTTAGAGCAACTAAACGGTAAAGCAGCAATTGGACACGTTCGTTATGCAACAGCTGGAGGCGGAGGGTTTGAAAATGTTCAACCCCTTCACTTCCGCTCTCATAGCGGAAGCCTTGCGTTAGCTCATAATGGAAACTTGGTTAATGCAAATGCATTAAAGCATCAGCTGGAAAACCAAGGGAGTATTTTTCAATCAACATCGGATACAGAAGTACTGGCTCACTTAATTAAACGAAGCGGCTATGAAGATATGAAAGATAAAGTAAAAAATGCTTTATCAATGGTTAAAGGCGCATACGCATTCGTTATCTTAACAGAAGATACGATGATGGTTGCACTTGACCCTCACGGATTGCGTCCGCTATCAATTGGACGATTAGGTGATGCTTATGTAGTAGCTTCTGAAACATGTGCATTTGATATTGTTGGAGCAGTTCATGAGCGTGATGTAGAGCCGGGTGAATTACTCATTATTAACGATGAAGGTATTCAATCAGAACGTTTCACATTAAACGTAAACCGCGCAATTTGCAGTATGGAATATATTTATTTCTCAAGACCAGATAGTAATATTGATGGAATCAATGTCCACTCTGCACGTAAAAATTTGGGGAAACAACTTGCAGTTGAGTCACCAATTGAAGCAGACGTTGTAACAGGCGTTCCAGATTCAAGTATTTCAGCAGCGATCGGTTTTGCAGAACAGTCAGGTATCCCATACGAATTAGGTTTAATTAAGAATCGATACGTAGGCCGTACATTCATTCAACCTTCACAGGAACTGCGTGAACAAGGTGTAAAAATGAAGCTGTCTCCAGTACGTAAAATTGTAGAGGGTAAACGTGTTGTTATGGTAGATGATTCTATCGTTCGCGGCACAACAAGCCGTCGCATTGTTCGTATGCTTCGAGAAGCAGGAGCAACTGAAGTACATGTACGCATCAGTTCACCACCTATTAAAAATCCATGTTTTTATGGAATTGACACGTCGTCATCTTCTGAGCTAATTGCTGCTACGCGCTCTGTTGAAGAAATTCGTGAATTAATTGAAGCTGATTCACTTGTTTTCTTAAGCAACGAAGGATTAGTAGATGCAATCGGCAGACAGTATGAAGGCAACGGCGGACAGTGTATGGCATGTTTCACTGGAAAGTATCCAACTGAAATTTATCCAGATACTGTACACCCTCATGAAAAGGTAACTTGTTAGTTTTAACGTAAAAAAGGAGTGACAACATGTCATATTCATATAAACAAGCTGGAGTTGACTTAGAAGCAGGATATGAAGCTGTTTCACGTATTAAAAAGCACGTAGAACGAACTGCTCGTGCAGGTATTATGGGAACAGTCGGCGGCTTTGGCGGAATGTTCGATTTATCTACATTGAATTTAAAAGAACCTGTTCTTGTTTCTGGTACAGATGGAGTAGGAACAAAATTGAAGCTTGCTTTTCAAATGGATAAGCATGACACAATTGGTGTGGATGCAGTTGCCATGTGTGTAAACGACGTGTTAGCACAAGGAGCAGAGCCTCTTTACTTCTTAGATTATATTGCTTGCGGGAAAGCAGTTCCTGAAAAAATTGAATCGATTGTAAAAGGAATTGCAGACGGCTGTGAACAATCCAACTGTGCGTTAATTGGCGGAGAAACAGCTGAAATGCCAGGTTTGTACGAAGAAGATGAATATGATCTTGCTGGGTTTACAGTAGGAGCAGTAGAAAAGTCAGAAATTATTACTGGAGATGAGATTGAAGCTGGTCAGCTGTTAATCGGTATTTCATCTAGCGGTATTCACAGCAACGGCTACTCTCTTGTACGTAAAATTGTTGATGATCAAGGATTAAATCTTCACGAAACTTACTCTGGTTTTAATGAAAAGCTTGGAGTTGAGTTATTAACACCAACAAAAATATACGTGAAGCCGGTCCTAAAAGCATTACATGCAGCTAAGATTGCAGGTATGGCTCATATTACTGGAGGCGGATTTGTTGAAAATATCCCTCGTATGCTTCCTGAAGGTTTAGGTGTAGAAATCGATTACGGTTCTTGGCCAATTCCATACGTGTTTGATTTCCTTGAAGAGCAAGGCAAGCTGGACCGTAAAGAAATGTTTGAAGTATTCAACATGGGAATCGGATTTGTTTTAGCTGTTGAACCTGAAGATATGAATAAAGTCATTGAAACAATTGAAAACGAAGGCGAAAAAGCATTTGTTATCGGACGTGTAAAAGAAGGAACAGGTGTTGAATTTGCTGGAGGGACGTTTGCATGATAAATATTGCAGTGTTTGCTTCTGGAAACGGCAGTAACTTTCAATCCATCTACGAAGCAACTCAGTCAGGTCGATTAAAAGCAAATATTGCGCTTGTTGTTTGTAATAAACCGGATGCATACGTAATTGAACGAGCAAAAGCATGTGGAATACCATGCTTTGTTTGTTCGCCTAAAAACTATGAAAATAAAGAAGCGTACGAGGAAGCAATTCTTGCAGAGCTTACATCAGCTAAAGTAGAATTTCTTGTTTTAGCAGGATATATGCGATTAGTTGGTTCGACGTTGCTTAAGCCATACAAAAATCGTATTGTTAATATTCATCCGTCGCTTTTACCTGCATTTCCTGGGATTGATGCTATTGGTCAGGCTTTTGATGCAGGAGTAAAAGTGATTGGAATTACCGTGCATTTTGTAGATGAAGGAATGGATACAGGACCAATTATTGATCAGCAGGCTATTCGCATTGAAAAAGGCGATACAAGAGAAACAGTTGAGGCCCATATTCATGAAATTGAACATCAATTTTATCCCGCGGTACTAAATGAATTATTTGAACAAGCCGCAGTTAAATAA

Protein sequences of DBSCAN-SWA_1

>NZ_CP018874|251799:260061|259482_260061_+|WP_013055043.1|DBSCAN-SWA
MINIAVFASGNGSNFQSIYEATQSGRLKANIALVVCNKPDAYVIERAKACGIPCFVCSPKNYENKEAYEEAILAELTSAKVEFLVLAGYMRLVGSTLLKPYKNRIVNIHPSLLPAFPGIDAIGQAFDAGVKVIGITVHFVDEGMDTGPIIDQQAIRIEKGDTRETVEAHIHEIEHQFYPAVLNELFEQAAVK
>NZ_CP018874|251799:260061|251799_253092_+|WP_013055036.1|DBSCAN-SWA
MIERYTRPEMAAIWTEENKFKAWLEVEILACEAWSELGHIPKEDVKLIRQNASFDINRINEIELETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTALSYLLKQANEILLSDVERFVEVLKEKAQEHKYTVMMGRTHGVHAEPTTFGLKMGLWYEEMKRNLERLKRAAAEVEFGKMSGAVGTFANIDPFVEKYVCEKLGISPAPISTQTLQRDRHAHYMSVLALIATSIEKFAVEVRGLQKSETREVEEYFAKGQKGSSAMPHKRNPIGSENVTGLARLIRGYMVTAYDNVPLWHERDISHSSAERVILPDATIALNYMLNRFANIVKNLTVFPDNMKRNMDRTLGLIYSQRVLLTLINKGMVREEAYDLVQPKAMEAWETQVPFRSLIEGEERITRHLSPEEIEDCFDHKHHLKNVDMIFERLGL
>NZ_CP018874|251799:260061|258448_259486_+|WP_029325686.1|DBSCAN-SWA
MSYSYKQAGVDLEAGYEAVSRIKKHVERTARAGIMGTVGGFGGMFDLSTLNLKEPVLVSGTDGVGTKLKLAFQMDKHDTIGVDAVAMCVNDVLAQGAEPLYFLDYIACGKAVPEKIESIVKGIADGCEQSNCALIGGETAEMPGLYEEDEYDLAGFTVGAVEKSEIITGDEIEAGQLLIGISSSGIHSNGYSLVRKIVDDQGLNLHETYSGFNEKLGVELLTPTKIYVKPVLKALHAAKIAGMAHITGGGFVENIPRMLPEGLGVEIDYGSWPIPYVFDFLEEQGKLDRKEMFEVFNMGIGFVLAVEPEDMNKVIETIENEGEKAFVIGRVKEGTGVEFAGGTFA
>NZ_CP018874|251799:260061|254799_257031_+|WP_064471263.1|DBSCAN-SWA
MSLLLEPNVEQIKEQKLYRDMGLTDEEFANVEQLLGRTPNYTETGLFSVMWSEHCSYKNSKPVLKKFPITGEKVLQGPGEGAGIVDIGDNQAVVFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIALLNSLRFGELTSPKVRHLFEEVVAGIAGYGNCVGIPTVGGEIQFEASYEGNPLVNAMCVGLINHEDIQKGQAKGVGNTVMYVGAKTGRDGIHGATFASEELSDQSDEKRPAVQVGDPFMEKLLLEACLELIKCDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLVPQRETGMTPYEMMLSESQERMLIVVEKGRENEIVEIVEKYGLEAVSVGHVTDDKRLRLTHNGEVVADVPVDALAEDAPVYHKPSQEPAYYREFQEQSAYAPTVENHSDMLVTLLKQPTIANKEWVYNQYDYQVRTNTVVSPGSDAAVVRVRDTNKALAMTTDCNSRYLYLDPEVGGRIAVAEAARNLVCSGAQPLAITDCLNFGNPEKPEIFWQIEKATDGMSDACRELSTPVIGGNVSLYNETKGEAIYPTPVIGMVGLIDDINHITTQYAKQKDDLIYVIGKAEAEFAGTELQKVLENGTVFGHSPKLDLAVEKTRQDQLLQAIREGAVQSAHDIAEGGFAVALAEKVMNGSGLGVDVTVDGEATAELFSETQSRFIVTVSPENKEKFEMLVQDVILVGRVTEDATLTVKHQENVLVQLSVEELTTAWKGALPCLLKSKA
>NZ_CP018874|251799:260061|253166_253874_+|WP_013055037.1|DBSCAN-SWA
MEKQELLYEGKAKKIYATDEQDVLWVAYKNEATAFNGQKKAEISGKAQLNNQISSLLFSMLHEQGITTHFVKQLSDHEQAVKKVEIVPLEVVVRNATAGSLAKRIGVEEGIRFEQPIVELYYKDDALGDPLILAEHAIFLKAATQEEIDSLKAQALQINEILSKFFKDKDIFLVDFKLEFGRTSQGDIILADEISPDTCRFWDVHTNEKLDKDVFRRDLGGLTEAYEKILQRIGG
>NZ_CP018874|251799:260061|253881_254133_+|WP_013055038.1|DBSCAN-SWA
MYKVKVFVTLRESVLDPQGVAVKNSLHRMSYEEVEEVRIGKFLELTIDSTDSLDERVKEMCEKLLVNTVIEDYRYEVEEVVVQ
>NZ_CP018874|251799:260061|254129_254816_+|WP_013055039.1|DBSCAN-SWA
MKFAVIVFPGSNCDVDMYHAIKDELGEEVDYVWHDTESLDQYDGILLPGGFSYGDYLRSGAIARFSNVMDAVKKAASQGKPVLGVCNGFQILLEAGLLPGAMRRNENLKFICKTVNLKVANNETMFTNAYGKDEVIAIPVAHGEGNYYCDEHTLQKLIENNQILFQYAGDNPNGSLQDIAGITNETGNVLGMMPHPERAVSDLLGSADGLKLFQSIVKQWREQNVVTS
>NZ_CP018874|251799:260061|257006_258422_+|WP_013055041.1|DBSCAN-SWA
MLAEIKGLNEECGVFGVWGHENASQIAYYGLHSLQHRGQEGAGIAVTDGEKVTVMKGVGLVNEVFGHGELEQLNGKAAIGHVRYATAGGGGFENVQPLHFRSHSGSLALAHNGNLVNANALKHQLENQGSIFQSTSDTEVLAHLIKRSGYEDMKDKVKNALSMVKGAYAFVILTEDTMMVALDPHGLRPLSIGRLGDAYVVASETCAFDIVGAVHERDVEPGELLIINDEGIQSERFTLNVNRAICSMEYIYFSRPDSNIDGINVHSARKNLGKQLAVESPIEADVVTGVPDSSISAAIGFAEQSGIPYELGLIKNRYVGRTFIQPSQELREQGVKMKLSPVRKIVEGKRVVMVDDSIVRGTTSRRIVRMLREAGATEVHVRISSPPIKNPCFYGIDTSSSSELIAATRSVEEIRELIEADSLVFLSNEGLVDAIGRQYEGNGGQCMACFTGKYPTEIYPDTVHPHEKVTC

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013055036.1|251799_253092_+	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	5.9e-19	25.5
WP_013055037.1|253166_253874_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3FGF0	Synechococcus_phage	1.2e-42	40.2
WP_013055038.1|253881_254133_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_013055039.1|254129_254816_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_064471263.1|254799_257031_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.5e-158	41.3
WP_013055041.1|257006_258422_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.3e-55	34.6
WP_029325686.1|258448_259486_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FZ01	Synechococcus_phage	8.5e-69	45.3
WP_013055043.1|259482_260061_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-29	39.2

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP018874|2166535:2193354|DBSCAN-SWA
ACTAATTACTTAGATAACGATCTAGCTTAGTAATGTTTTCAGATTCATATTTCTTTGTAATATGAAGATATACATCAGCTGTCATTTTAATGTTTGTATGTCCTAGCCGATCACTTACAAATTTAATATCAGCTCCGCTCTCTAATAACATAATTGCATGAGTATGGCGTAAACCGTGAGGGCTTATGTGATGCAGTTTAGCTTTGTTGGTAATAGCCTTCATAATATCGTTAATTCGAAATTCACTAAGCGCTTTACCATTGGCTTGGGTAATCATGTACTCTTGTTCAATATAATTAGCTCCATATTTAAGTTTATTTCTTTTTTGCCAAGTTTGATACTTTTTTAACTCAGTTACCAATGTCTCATCAATACTTATTGTCCGCATACTGCGTTTCGTTTTAGGAGGCTTTACGCCGTGACTGCTCCGTGTTTTAGTGATGCTAATAGTTTTATCTTTAAAATTAATATCGTCCCAATGCAATGCAATTAATTCACCTTTTCTCATGCCTGTACGCAAAAGGGTAATAGCTACGATATATTGATAAAAAGGGCACTGTTTTGCTGTATCCATAAAAATGGTAACTTCATCTCTTGTAAGATAATTAATTTTTCTCTCGGAAAGATCCTTTTCTTTTTTTATAGAGATATTTCTATATTTGTTGTAGGTTAGCATTTCTAGCTCTACCGCTTTATTTATAGCAATACAAAAAATCGAGTGAATAGCTTTAACTGTACCTAGTGAATAATTCTCAGTCAATCTATTGATGAATTTCTGATATTCTAGTCTAGGTAATTGATTAAGCTTGAAATCACCTAAGTAAGGGATAATTTGATTATTAACGTAGGTTTTTCTGTTTTTTAATGTTCGCAGCTGAACTTGACTACCATATACCTCGAGCCATTCGTTAAACCAATCTTTAATTAATTTTTCCCGGTTCTCTAAAAGGGAATGTTTGCCCAAATATATTTGTTTTTCTAATTCACTGGCTGCAAGTTTAGCTTCTGATTTAGTTCTAAAACCACCTTTTGATATTTCTTTCGTTTTTCCACAAGCAGGATCTACATATCTAATTCTGTATTCCCACTTCTTTCCTCGCTGGCGATAGCTTGCCAATCTAATCACCTCTTCAAAAAATATTAAGTCAATCGATAAGAATTTCTGTTTCACCTCCTTTAAGTAACTTGTGTTTAAAATTAGTTGTTTTTATGTATATGGATAACCCCGTTGGCGCTATAGAATATTTCGACTGAAGCAGGTTGAGCCTTTAATATTTTCTTTATTGCATATGATACCTCAGATTGTTTTACGTCTCTTTTAAGATCCGATATACTGACTTTTTCAGACTTTTCACAGCTACTGTAAATAATCTTAGTTACTCCATTACTAAAAATTTTGATTGTATTCGTATCTTTACTTTGGTTTTTAAAACAAGAAACGAACGTTTTTCTTTCTGCAGTTACATCTTTAAATCTCAAGTGAATCACCTCTGTTAGGAATGTATGTTCTGTTTTAAGGTAAAGTTAATCCTTCATTTACTCGTGAAAGAGTAAGTTTAGAGGATAATGGTTTAGAAGTTTAGCTTTTTAATAAAGCGCGGAATAAAGATTATACATCCCATTAATTAGAATCAGAGTTAAGAGGTAATTTTTCTATAATTAGCGGATCAAATCCTATTAAGTAACCATCGTAAAAAGTGCAAACACCATATTTTTCTTTATAACAATCTAATGCTTCTTGTAAAAATTTTTCTGTTACATTTAAAAAAGAAGCAGTTTCATATCGATTTGTACAATTATTATGAAAAGCTTCAATAAGACGAGACAAAAATAATATTTCGTTGTAACCCCAACGGCGAGCTAACTTTTCCTGCTTTCGGTTTACGAGGTTATCCTGATTAAGGATATTTCCAACAGTTGTAAAGTGATGACCTAACTCTTCGGCTAAGATACAATATTTTTCTGTCTCATCCAGATTTTTATCAATTAGGATACGACCGTCATAGTATAGTCCTTTGAAGCCATGCATTAAAGGAATCTCATTCATAGGAATATTGCTGTATTTAGACTGTAACTTTTCATATGAACTTAACATTGAGTGTACTCCTTTTATTTATCAAACTGTTTGCTGAAGACATAATCGATATAGTTTAAAACTTCCTTCATTTTTTCTTCAGTTATATCTTTGCCTTCTAAATGAGCAGCAATTGTTTGAATAGGAGTGGGTTCCTTTTTATTGTTTAGCTTTTCAATTCCAAGTAAATAATCAAGCGAAACATCAAAATAATCAGCTAAGAATCTTGCTGTATCAATCCTTGGTTCTTCTTTATTATTTTCCCATTTGGAAATCATGCTTTTATTAATTGATGTTCCATATTGATCATTTAATGCCTTTGCTAACTGATCTTGAGTGATTTTACCTCTAAGCTTTTTTAAAGTTTCCCCAAAAGAATATTTCATTTCTTTACCTCCTTTTCTAACAATTTAGATGCAGTTTAATTATAAGTTATTTGTTTCGATACCGCAATATTTATTTCGATATAAGTTAATTAAGTTGTTGACATCGAAACTTTTAAGATGTATATTTGCATTTTTAAGTTTCGAAAATGACAACTTATAAGGGGGTGATGAAGTGTATGAGATTAAACGGAGACATCTTCCTTATTCAAAATTAAAGGCTTATATGGTGGAAAATCGCATTACGCAAAAGGAATTGTCTAACTTACTTAAAATTTCAGCAGTTGCATTAAATCAGAAGATTAATGGGACTGGAGGAGATTTTAACTTGAATGAAGTACGTAACATATGTCGACATCTTAAAATTTCATCAGATGAGTATTTTATTGAACCTCAAGTTTCGAAAGTGAAAACAAAATTAATGGAGAGGGTAAATAGTGATTAATGTTGAGATTGATGGAAATGAAGTTAGAGAACTGTACTTAAAAACTCTTAAAGAAAAAATAGATGAAGTTGACGCTGAACTTATATTTTGGGATACCAAAGAATTAAAAAGAAGGACTTGTATGAGTTGGAATACTATACAAAAAGAATTTTTCTTTGATCCCCGCTTTCCAAAAAGGAAAGTAGGGGGCAAGTGGTATATATACGCTCCTAAAGCAAAAGAGTTTCTAGAAAATTGGTTGTTTGAACAATGTAACTTGTAAAAGGGGTGAAGGAATGAAATTTATTGAGGCTATTCAAAGTCAACTATTGTGGAACAAAGAGCAAATAAAACGTTTGAGAGTAGAGCTACTTACATCAGATACACCAATAGCAATTGAAAAACTGATATATGGGTATGAACAGCAAAATTTAGCTCTGTCTTTTGTATTGGAAATGGCAGGTGAATAGGGAAAGGAAATTACTCTTTCATTATCTACTTTCTTGTTCTTAATATTCCTAGGTGGTCCATCAGCAATCCTATTAGTCTTTTTAATAATCTATAACTCTTTCACAAGAAGAAAGGAAATTTAAAGATGAGCAGTATTTTGATATCTACTTTTCGATATTTTTGTGAAACATGTGGCTACGAAACATTGAGTTGTAATGTTGAGGTCAAACTAAAATGTTTATGTAACTTACTTGTTGAACATGAGGAAATAGAAGAAGCCATTAATGAAACTTATTAATAGAATAAGAGAGGAAAAATAAAAATGAAAGAATTAGTTAGTATTCAAAATGGGCAAGCTGTCACGGATTCTTTAACTGTTGCTGAAGTTTTCGGTAAGCGGCATGACTCAGTGATGAGAGATATACGTAACCAAAGAGTGAAGTTAATTGAAGCTGGAATGGAGGAATTTATATTCCACAACTTTGTGGAACGTGAATATCAATCTCAACAAGGTAACTTTTATAAAAAATATGAATTAACAGAGGATGCATTTGCGGTGGTTGCTATGTCTTATATAACACCAGAAGCAATGAAATTTAAAGTTGAATTTTTACAAGAATTTAAACGAATTAAAGCAGAATTACAGGGGAAACCCAAAATTTTAACGGAACGTGAGCAATTAGTGGCCTCTATGAAGTTAAGCATAGAAGCAGTTGAAGAAATTCCTGCAATAAAAAAGGAAGTAACAGATTTAAAGCGTGTCTTTTCTGAAGAACTAACCCTTAATCATGGTCAACAACAATCTTTGCATCATGAGATTAAGAAGCGTGTTGAATCACTTATAGGAGATTATCAAGAATGCGGTTTTACCAAACAAAGAATGTATTCGGAGATTCATAAGAACTTGAGACGAGCATTTTCAGCACCTAAATATATCTTTGTAAAAAGGAAAGATTATCAAGAAGCTATTACATGGGTCAAAGCCTGGAGACCATTATTATGAATCATAACCTAATTGATGTCTTATTGAGTGAAAAATAAAAGCCCCTGCTGCAACAGAGGCCCAAAAGAAAAAATTCTTACGGATAGTATAACACGAAGAAGGAGAGCTTAACATGGCTAAATATAGACAAGTTCATACAACTTTTTGGCAAGATCCTAAAGTTTTGGAAGAAATGACGCCAGAAGATAAGTATTTTTATTTATATCTTCTTACCAACCCAAACACTACTCAAATTGGTGTATACCAAATAACCAAAAAGCAAATGGCTTTTGATTTAGGTTATTCTACGGAATCGATTAATAGCCTCTTACATCGTTTTATTACATTGCATAAACTTATTAAATATAACGAGCAGACAAGAGAATTAGCTATCCTTAATTGGGGTAAGTACAATTTACATAAAGCTGGAAAGCCCGTAATTGACTGTGTAAATAAGGAACTAAAAGAAGTAAAAGACAAAACATTGTTACTAGATATCATGAATCATATTCCTAATGATTCAGTACTTCAAGCTTTTTCACGACACGTAGACGACACGTACAACGATACGTCAACGTGCCGTGGACAAGAAAAAGAAGAAGAAAAAGAAGAAGAAGAAGAAAAAGAAAAAGAAGAGAAGAAGAAAAAAGGTAGTTCCACAGCTTTTGAATTCTATGAAAAAAACTTTGGTTTACTCTCATCTCACCTAATTCAAGAAATTAATGCTTGGTTAAATGATTTTAACGGGAATCATGAAGTAGTTATTGAAGCATTAAAAATTTCTGTTGAACGCAATAAACGAAACTGGGGATATACAAAAGCTATATTAAAAGATTGGTATAGTAAAGGTGTGAAATCTCTATTAGATATAAAAGCTCTAGAAATAGAATTCAAGAAAAAAAGTCTATCTACAAAGACAAAAATTGTTCGCAGAGAGGTGGTGCCTGAGTGGTTGAATAATAACAATAAGATAGAAGAGAAAGTAACATCCGAGTATGATCCTTCTTTCGAAGAAGAAAAAAGAAAATTAGAGGCTGACCTAAAAGCACTTAATGAGGAATTAAAAGGGAAAAGCTTATAAAAAGGTTCTGTCAATGCAAAGAGGAAAGGGAGTCTCTCCATGCGTCCCTTTCCACAAATTTTATAAACCTTTTAGTGAAGATGAGAGTATTGCGTCTAATTAAATGAATTATGCTCAATTTTCTTAAAGGAGGGCGTTAAAAGGTGGAAAACCAATTATCATTCAATCTTCCAGAAATAGATAGAAAAAAGACGCAACAAGCAGTAGAGGATGTTTTAGAACAATATAGGCTATTTAAATACTTATCTTTTGAAAAGAGAGAAGTATCTATTACTGTCAATCCTGAAATCCGATACCACGGTCCTACATATCAAATGAGCGACCAAACAGCATCTATTGCATCTCATAATGTGGATGCAGAGAAAATGAGAAAAGATTTTTGCTTTCGTGTGGAAAGAGCAGTAGCACGATTACCGAAGATGGAGAGGTTTTTAATTGAAGAACGCTATATGACAAATGAAGCAGACTACCTTACGGATTATAATATATATTGCTTCAAGTTTCAGCCACCTATAAGTGCAATGACATATTCAAAAATCCGTTGGAAAGCATTTTATAGACTCGCTCTTAACTTAAATATTGCTGTCACTAAAAAAAGCCACTATTAAGTGGCTTATGGATTTACAAATTCTATAATCATCTTTTTCTCAAGTTCATACATAACTTTGAGACAGTTTTCGCAAATTTCAATTTGAGGAAATACGCCCTTTAGCGCAACATCATTGAAATGTCTTTTAAAAGTAGCAAGGTCTCTTATATCAATGTTATAAATCCCTGCGCTATCATATTCATCTGTGGTACATAAATCGCATCCATGAAGAGGGTTATCTTTACAACATACACAATAAGATGACTGATTGTCATCTTCATCATAATAGGTGAAAGCTGAATTTTTTTCACATTTTATGCATTCGCTACTTGGAATTACCCCACAATCAAAGCAAATTAAACAATTAGAATCGGAGTCGAATTGTAGATAATCTGGGGTTCCACAATTAGGACATGTATCTACCGGAACTTGATTAGACCTAAGTATATGCAGGTATGATACAAACAACTCTTCCTGTAAATATGAATCCTCAATAGACTTTATAGCATCAACTACTGTCGAATATTTTTGATTGCAATGAAAACATTTCAGACCTTGAGGGTTGTCTTGATCAACTAATAGTTTTTCTAAGGAGCAGACAGAACAAGGAAGATGAGAATCTCCTAATTTGTATCCAATTACTTTAGAGTAATATTCTTTTCTTATAGCTTCGCTATCTACGATAAGAGACCAATTATCTACTTGATTATGTAAAGTTTTGTTTAAAAATTGTTGCACTATTCTATCCAATGAATATAGAGTTCTTGCATACATTGTGTTTGGAGCTACATCTAGCCTAACATCTTTATGCATAATTGAGTTGCGAACTTCTCTTATTGATTTAAAGATTTCCGCATCCTTATTGTGAATTCTTATATTATCTTCTGCATAGATTCTGTTTATTCTAGGAATTAACTTTTCCGCTCCGACCGTCTTATCATCCATAGAATCTATATTGCTCAATACAAATAAAGGATGCTTATTTTGAAGTATACTCTTTAGGATTAATTCAGTCCCTGTCGCAAGAAATAGGATTGCATACTTATATTCCTTTGGATTGTTATCATCCTCAGCAATTAGGTAAGATTGCATACTTTTATTAATAAAATCGATAGCGTTATCATATAACACTTGTTCTAAGAATGGTTGCTTCGTACTCAAATTTAAACACCTCATAAGAAAAAAGATAAGAAAATAATTATAATACAATCTATTAAATTATAGCAATTTATAACAAAAGATTTAGTGGAAAAGTAAAAAAAAATTTTATGTTAAGCTAATTTTAAAGTGATAATTTAATATTATGTTAATTTGTATAGAAAAATCGTTAATTGGTCTTAGGATGACTTTTTTTGCAATACTCAACAATTTATATGATTATTTCTCCTTATTTATTGAAGATATTTAAAAATACTAGGCACATATATTTATTTGAAAGGAGGATAAATATCCTATATTGTCGTATTGCTAGACAAGGAGGCGATATTAATGAATGTTGAAAATATTGACATTATAGAAAGTAAAGTGTTTGGTCTTTATATAAGTGAGCTCTTCTCCTTAGTCCATGTTATTAAAAGAGAATGCGAAGAAATCTTTAAAGAAACTAAAGAGCCTGCTACAGGATATATCATGCAAGTTTCACCGGAAATACATAGTAAAATAAATACTGTAATAATAAACTCTGCTAATCTTAAGAAACTTCTTTACTCCCCTGGCGACAAAAAGAAAAAAGAATCTACTAAAAAATTCAAAGTCAGAAAGCAGAGGGAAGCTCTATTTAAAGAGTTAATTTTAAACTTGGACTTAGAAGAGATTAGTAATACGAATGTAAGGAATAAATTAGAGCATTTTGATGAATATTTAGATGATATGACATTAAAATTAATCGATGAGGTATCAGAGTTTAAAAAGAAATACCCTGCAGCTGTGTACAACATGATTTTTTCTAAATGGGAAGCGATTTCTCCGAGAGCATATCCAATCAGGCTATACATCACTGCAGAAAAAACTTTTTACCACATGGATTGGTCAATTAATCTTGGGAAGATATACAAAGAAGCAAAGTTAATTTTAGAAAGGCTGGAGAATTCAGATTTGTTGCCAGATGAAAAGCCTGGTGGATTAATTGTAAAATTTCAATAAAGTATGAGGATGCTGATTCATCAGTGTCCTTTTTATCTAGTTAAGATAATAATTTGAAATATTTCTTATGGTATTTAAGTAATATGGCATGTATATTTGCTAAAGCACTGTATATTTTTGCTGATACATGTTATATATGGTAAGTAGGAGGAGATTAAATGCCAGAAAAGCAAACTTGTTTTATTATTACTCCAATTGGATCAGATGATTCGTCAATAAGAAGAAGCGCTGATGGAGTAATTGATGCTGTTATAGCACCTATATTAGAAGAAATGGACTTTGAAATTATAGTAGCACATAGGATGAATGAGGGAGGATCTATTACTAGACAGGTCATTCAAAACATTATTGATGCTGAGCTAGTTATAGCCAATTTAACTTCTTTAAATCCAAATGTAATGTATGAATTAGCAGTAAGACATGCTATTAGAAAGCCACTTGTTCAAATTTGCGAAAAGGGTACCGTACTACCTTTTGATATTAGTGAGCAGAGAACTATATTCTATACTAATGATATGAAAGGTACTGTGGAGTTAAAAGCTGCTTTTGAGGGAATGGTCAACGAAGCATTAAGGGATGAAAAACCGGATAATCCAATTTATCGAGCGATACAAAGTGAAATAATAATTAAAGATACAGAAGTTGGAGATACTGATAAATATTTGGTTCGTAGAATGGATGAACTTGAATCTAAGATAGTGAGTACTCTTTATAATAGAGATGTTATAAAGTTAAACCCTCAGCGCTATAATGAACTTTCTTTTAACCTTGATGGGTCAGAAATCCGTATTGCAGAGAAGATAATTTCCAAGATGTTGCATGAACAAAATGGTAGAGCTCTTAAAATTGAAGAAGTACAAGAAGCTTTAAGCAATGAGGTCGATATTTATCTTTCTAATGATATATTGCAAAAAGTTATTAAAAAGGTAAGGAATGAGTTTAAGCGCAGTCTTCCACTTTAATAGAATACGTAAAAGAGGATACTAAACAATTAGTATCTTTTTTTTTGGTTTTCTTTAATGGTGAATAGAGGAATACCTATCGATTTACTCAAAAAAGATATAAAAGGAATGATGTTACAGGAATAGACAAGGTTATAATAATTATTTTGTATAAGGTTGCAATTGTTAAACCGTAGTAGGGCTTACTTAACTATTATGGGTATGGTGAAGTTGAATGTATATATAATCCCATTTATCAAAGAGAATCATACATTATGAAAAAATATATAACAAAGAGACAAAAGCTAAGGTTCTATAAATCTAAAGAGTGGAAAGCACTTAGGCTTGAAGTATTGAAGCGTGATAACTACGAATGCCAGGAGTGCAAGCGCAACGGATTAGTTTATACAGATAAACACGATCCAGAGAAACATAAGCGGCTAGATGTTGACCATTTAAAAGAAATAGAAAACTATCCTGAACTTGCTTTAGACATTGATAATTGCGAAGTTAAATGCGTTAGATGCCACAACAAAAAACATAATCGTTTTCAAAAACGCAGGAAAAAAATTTTTTGGGACGATGAAAAATGGTGAGCACCCCCCATAAAAAAATTCAATCAAATTTTTTATGCCTGGGGAACGAGGAGGGGGCTCGATTTTCTAAATTTGCCGCGCTTTTTCGTGAGTCTATTAAATTAGGATTAATTGTAAGTGGAAAGGAGGGGACCAGGTGGCTAAAATCAAGCGAGAAACATTGCGGAAACGGATTGAAAAAGATCTAAGAAATCAGCTAAGTGAGAAAAAGATTGTAGGAAATCACTATGAAGATTTGGTACAAGACTATTTATCTTTATGGGATTTAAAATGCAATCTTATTGAGGACATCGAAACGAACGGAATAAAAGTTACTGGTATGCATGGCCCTAAGTCTAATCCTTCCATAAACGATTTACATAAAACGAATGATCGAATGCTAAAGATCTTAGATGCTCTTAGGTTAGACGCATCTCCTGAAGAAAAGAATTCTTCTTCAAAACCTAAGCGCTCTGTTAAGGATTTAGTATGATAAGCAACAAATACGTTGATGAATATATTCACCTTTACGAAACAGGGGAAATTAAGCTAAATAAAGAGCGCATTATGCTTATTAAGTACCTACAGAAACACGTACTTGTGAGGGATGATATATATTTCAATGAGGAAATGGTTGAGAACTATATAAAGTTCACAGAGAAATGGTACTTCAAGCTACAACCATTTCAGAAGTTCATAGCGCCATTTGTTTTTCTTTATTACAAAGAAGATGACAGCGTTTTTTATGACCAGTTTTTTATAACGATGTCCCGTGGTGGCGGGAAAAACGGTTTTATCTCTAGTTTAAGTCACTTCTTTATTAGCCCGCTGCACGGTATTCCTAAGTACAATATCTCCATTGTTGCTAATAATGAAAAGCAAGCAAAGCTCTCTTTTAAAGAGGTTTATGATTGTATAGAAAATAACGAAGTGCTTGAAGATCTTTTCTATCGTACCAAAGTCGAAATAATGGGCTACGATACAAAAAGCATTATGCAATACCATACATCAAATGCCAGTTCTAAAGATGGTTTACGTGATGGATGTGTTATTTATGATGAAATTCACCGATATGAAAATTTTGATGTTGTAAATGTATTCTCTAGCGGGCTTGGTAAAGTGCCCAATGCTAGGGAATTTTTTATTGGTACAGATGGCTATGTTCGTGAAGGTTTCTTAGACAAAATGAAAGAACGGGCTATGAATATTTTAGAGGGCAAAGATTTAGATGATCCTCTTTTTCCGTTCATATGTAAAATCGATGAAGCCAAAGAAGTTAATAATCCAGATATGTGGGAAAAGGCCAATCCAATGTTTAGTGAGCCAAGAAGCTCATACGCAAAGGGCTTATTTAAAAAGGTTTTAAGACAATTTAAGCAGCTGGTTAATAATCCATCTAACAGAGAAGAGTTTATGACCAAGCGCATGAACTTTCCAGAAACGGATCTTTCAAAAAGTGTTGCGTCCTGGGAAGAAATTTGGAGAACAGGTTATGAAGAGGACGGAAAAACACTTAGAAAGGTTCCTGACTTAAAACATCGTGTAGCTGTAGGCGGTCTTGACTTTGCAAGTATCAAAGACTTTGCAGCTGTTGGGCTTTTGTTCAAAGTTGGAGATGATTATATTTGGAAAAGCCATTCTTTTGTTCGTAAAGGGTTTCTGGACAAAGTGAAGTTGAAGGCTCCTATAAAAGAGTGGGAAGAAAAAGGACTGCTTACAATTTTAGATGAACCAGTTATTAATATTAAACACATAGTTGATTGGTTTGTAGAAATGCGTGAGCTATACGGAGTTAATACAATTGTTGGTGATACTTTCCGCTTAGATCTAGTCAAAACAGCTTTAGAAGCAGAAGGATTTATATTGCTTTATATAAGAAATCCAAAAGCCATTCATTCTCTTTTAGCTCCACGGGTAGAAACGCTATTTGCTAATAACCATATTATTTTTGGTGATAATCCAATGATGCGCTGGTACACAAATAACGTCCTGGTGAAAATTAAGCCGGATGGCAATAAAGAGTATTTAAAGAAAGATGAATTTAAGCGGAAAACAGACGGATTCCAAGCATTTATTCATGCTTTATGGCAAGCGGATAATCTTCTCACTGATGAATTAGATTTCATGCTATCCAATATTAAGTTTTAAAGGGGGGGAACGAAAGTAGAAAAGTCAAAGAATAAGTGTTGTTTCACAAATCATTGGCATTTTAGTAGAAAGTGAATGTAGCGCAGCAGAAGTATTAGAAGTTCTTAAAGAAGTAGAACAAACAATGTTAGAAAGGAGTTGGCACATTTCTTCAAATGAAAAAGCAGACTAAAAAAAGTCTGCTTAAAATGTTTAAAGGTACATGTTAATGATTGTAGAAATGCAATTAGTTCGCAAGATTAACGGATTATTACTATTGAAATTAGTGTTTTTAAAGGCGAAAGCATGATTTCTATATTCTAATTTATCATTAGGGTCTTTTCTTTGAATGCTAATAAAGTTGTATTTAACTAAATTATTCAATAACTCGTAGTAATAATCTTTTTGCCAGGAATAACCTGAGTGGTATATATCAGGGTTCGGCAATTCATTGTGGAAAGCAATTTTGTCAAAACCATCAATAATGATTTCCGAGCCATCAGAAATACACACTTTTAAAACCATGTCCATAACATCCCCTCCTTCCATGGAAATTATATCAAATAATTAAGACTAGTAATATAAAATGATAAATTACTTAAAGGGGGTGAGAACAATTGGATTGCTAGATACCATTTTTAAAAGAGATAGTGAAATTGGATATATGTTTGATGTAGAAATGTTTGTTGAAACAGCAAACAGAGTCCATATGAAGAAATTAGTTTTAGATACTTGTATTGCTTTCTTAGGAAGGACAATTAGCCAGTCAGAATTTAGGGTTAAGAATGGCAAAACATTTGTGAAGGATGAACTTTATTATCGCTTAAATGTTAGGCCAAATAAAAATATGACAGCTAGTACATTTTGGGAAACGTTTGTTCACAAATTGATTTATGACAATGAGTGCTTAATTATTCAATCAGATGATGATGATCTGCTTATTGCAGATGATTTTCAACATAATGAATATGCGGTATTTGAAGACACGTTTTCAAATGTAACAGTCAAGGACTATACATTTAAGAGGGTTTTTAAGCAGAGTGATGTTATCCATTTACGATACCGAAACGAGCGGTTAACACCATTAATTGACGGTCTTTTCACAGATTACGGGGATCTATTTGGACGAATTTTAAGTTCCCAAAAGCGGAAAAATCAAATTCGCGGTACTGTCGATATGGATATGATAGGAGCTAAAAGCCCACAGCATCAAGCAAAGCTCCAGGAATTCATTGATAACATGTACAAGGCTATCGGTGAAAAAGATGTGGCTATTATTCCGCAACAACCAGGCTTTAAATATTCGGAAACGTCTGGCGGTGGAACCACTGGCCAAAGTGTAGATGAAATTAATAAAGTGACAAATGGTTTCTTTAATCAAGTAGCAATGGCTTTGGGTATTCCTACTAGCCTCGTATATGGAGATATGGCCGATATAGAAAAGCAAACGAAAAATTACATGCTTTTTACTATTAATCCTTTGCTTAAAAAACTAGCGGATGAAGCAAATGTGAAGTTTTTTGAGCAAGATGAATATCTATCTGGCCAAAAGATTGATATTAAAAGCATTTCTTATCAAAGCTTATTTGATCTTGCTACAGCGATTGACAAACTTATTTCTTCTAGTGGCTTTACTGGTAATGAAATTAGATTGGAGACGGGTTATGAACCTTCCGATGATCCGAACCTGGACAAACATTACATTACTAAAAACTATACTGAAATGAACAAAGTTGAAGGAGGTGAGGAACAAAATGACGGTGAAAATTGACGTTAAAGGGCCAATCATTTCAAATGATGAAGCTTGGATTTATGAATGGTTTGATATAGATTTTACTAGTCCAAAAACGGTTATTGACCAGTTAGCTAATGCAAATGGTGACAATGTAATTGTATCTATTAATAGTCCAGGCGGCTATGTAGATGATGGATCAGAGATTTATACAGCTCTGAAAGCTTATCCTGGACATGTAGAAACTCAAATTGTAGGTTTAGCTGCAAGTGCAGCATCTTTTATTGCTACTGCTGGTGATAAGGTAGTGATTGCACCAACAGCAAAATTTATGATTCATAATGCTTCTATGGGTAACTTGGGAGATCATCGTTCAATGGAAAAAGCTTCTCAAATGTTGAAGACAACTGATAGAACCATTGTAAATGCCTATGTATTAAAAACAGGCAAAGATGAACAAGAGCTATTAGATATGATGGCAGAAGAAACATGGATGGGGCCACAAGAGGCATTAGAGCATAATTTTGTGGATGAAATCATGTTTATGGATAATCCAATTAAATTAACTGCTTCTAGTGCTGCATCTGCAATGATTCCACAAAAAATTATTGATGGCTTTAGAAATGGAATGATGAACAAAGGTAAGCCTGAAGGTGTAACAAAAGAAGATCTAAAGGCATCACTTGCAGAATTCAAAAATGAAATTCTAAACGAATTACAACTTAATAAAACAAACGAACCAAAAGAGCCTACTCTTAAACCAGCTAATAAGCGGGATTTGAGTAAGCTCTTTTTAAGTTTATAAAATTGGAGGAAGTCATAAATGACTATTAAATTTAATAAATCAGAAGCTATGAATGAGGCTAAGTCAAAATTAGCAGCGGTTTTAACAAATACAGAATCTACGGAGCAAGAGCAAACAGCAGCCTTTCAAACTTATTTTGATACCTTGCAGCACGAAGTTGCAAACAATGTTCGTAAGCAAGTAAATGATGAAATGCTTGACCGCTCCATCCTGCAGCAACGTGGCCAAAATGTATTAACTTCTGCTGAAATGAAGTTTTTTAATGCGGTTGTACAAGATGGCGGTTTTAAGGATGATTCTATTCTTCCAGAAACAACACAAGAGCGTGTATTTGAAGATTTAGTAACAGAGCATCCATTATTAGACGCTTTAGGGTTACAGGATCTAGGGGCGGTAACACGTTTCATTTATTCAGATCCAGAGGGCGCAGCTGTATGGGGGCCACTATTTGGTGAAATCAAAGGCCAAATTAATGCTGCCTTCCATGAAAAACAAATTGGCCAATTAAAACTAACTGCCTTTGCTGCTATTCCAGATGATATGCTGCAATTAGGCCCGGTATGGGTGGAGCGATATGTACGAACAGTTATTGTAGAAGCTTATGCTGTAGGGTTAGAAAATGGATTTGTAAATGGGAATGGTAACAATCAGCCAGTAGGTCTATTAAAAGATGTTAACGCTGAAACGGGTGCAGTAACAGATAAAGCATCATCTGGTAAATTAACTTTTAAACCAGGTCGAACTACTGTAATTGAATTAAAAGATGTTGTTAAAGGTCTTTCTAAAAATGCAAAAGGCAAAAACAGAAAAGTTGCAGGAAAAATTGTTATGGTTGTTAACCCATTTGATAATTTTGATATTCAAGCTTCTGCTACTACTCAAAATGCAAATGGTGTATACGTAACAAACTTGCCTTTTAACCCGCAAATTGTAGAATCTGAATTTGTTCCTGAAGGCAAAGTAATTTTCTTTGTTAAAGGTGAATATATCGCTGCTGTTGCTGGTAACTACCAATTGAAAAAATTTGATCAGACGTTAGCTATTGAGGATGCAATTCTTTACACAATCAAGCGCTTTGCAAATGGTTTACCAAAAGATAATAAAGCGTCCGCTGTTTATGACTTGGAAATTGATGAATCTTTAGAAGCGGAAGCACCAGCAGGAGCATAAAGGAGCTGAAGTGATTGGAAATCACAGATAAATTACTTCAGGAATTTAAAGATAGAATGCATTTTACACATAATTTTACACATAAAGGAGAGGACAGCAATTTAAAAGAATTGTTGTCCTTTTCTATTGACGATATTACACGGAAAGTTGGAGCATTTAACATTGAAGAAAACAAGGGAGCAAAAGAATTGGTCTTTGAGCGTACCCGCTACGCTTACAATGATGCTCTTGAGTACTTTGACAAGAATTTTCAAAGTCAAATTAACAGTGTAGGTTTTTCTATAGCTATGGAAACTAAAGAAGGTGATCCAGATGCAGCCGTTTAAATATACGCCTCCAAGGATTCATACAGGGGAATTAAAAACATGGGTTACTTTTTATGAAGCTAAAGAGAACGATGGGCCACTACCAGGAGAAAATCCAAGGAACGTCCTTTATGAATGTTGGGCCAAAGTTGATGAAGTATGGACTAAAGATATAGAAATTGCTAAGTCAAATGGTACTTTATCAGACTTAACTATTTCTATTAGAGATCCTAGAGGTGATTATTCACCAACAAACAAACATTATGTGCAAGTTCATTCCCCTGAATATGAGGATTTAAAATACAACATTAAACAGGCTTTTCCTGACTTACAGAACCGGGATTTCATTAAAGTTATAGCCGAGGTATCAAAATGAGTGTTCAAATTAAAGGTTTAAGTAATCTGTTAGCGGATTTAGAAAAACGTCTTGGCCCTACTAAAGTAAAAAGCATTAGTGAACAGGCTTTAAAAGAGGGCGCACAAGTTTTTGTAAAGGAATTAAAGACACAATTTGAATCCTTTAAAGATACCGGGGCATCCATTGATGAAATTACGATTTCAGAGTCAGAGTATGTTGCTGGTGTAAGAACAATTAAAATACATTGGCGTGGCCCTAAAGACAGGTATCGGATCATTCACCTTAATGAATGGGGCACGGTTAAGAATCCTAACCCTAAAGGTAAAGGAGCAATTGCCAGGGCCATGCGTAATGCAGAAAATGCCTATAAAGCAGCGGTGAGAGAAGCTGTAAGGAGAGGTATTTAATGCTCTATAAAGTATACGATGCACTAAATACTAGTGATCTTATTAAACAAAAGGTAGGCAAAAGAATTAAGTTTTATGAATATCCGTCTACTGATAATATGCAAGGCGTTTATATTGTCATTGATCCAATAGATGTACCTAAGCCTGGCGATTATGCAGATAATAAATGGTTAACAGATGAATATTTTTATCAAATTGAAGTCTGGTCTATGAATCTGTTTGATACACAAGCTGTTGCAAAAGAGGTTCGTAATATTATGTGGAAGCAGCTTGGTTTTGCTCAACTAATACCAGGTCTTGATGAATTTGATAAAGATACAGGAATTTACCGTGATGCTAGGCGCTATCGCGGTAAAGAGTATGTAGAAATTTAAAGGAGGAAGTTATAATGGCAGAAGAAAAAAAGAATTATCATGCTTCTACAGGTGTAGATGAATTTTACTATGGAGAAGTTGGAGACGGTATAGTTGCTTCATATATTGAGCGGGTAGAATACTTACAAACTATTGATGTAGATATGCCTCAAGATATTACCCGTGCTTATGGAGACAATAAAACAGCGGAAATGGCTGTATCAAATGGTGATATTAAAGTTACTTCTGCTTTTCATAAAATTCCTATGGAAGACAAGCAAAAACTTTTAGGCCTTGAAGTCGTGGACGGTATTACCTATATGGGTAGTAAAGATAATCCTCCATATGTTGCAACCATTTTTGCTAAAACGTATGAAGACGGCTCTAAAGAATATGTTGGCTTGCCAAAAGGTCTATTTACCAGACCAAAACTTTCAGGGAAAACTAAAGAGGATGGAACAGAATTTTCTTCTGAAGAAATCGAAGCACAGTTTATGGATCGTAAAATTGATGGACTAGATGAAGAGAAATCTGTTGCCTTTGCTGTTGATAAAAAAGGCGAAACAACAAATCGTGATGCATTATTTATGAAGATTTTTGGTAAGCCTTATCCTGGCACTACAACAGAACCAGCGGGGGCGTAATTTATGGCCAGTAATAGAAAATTTGAAGTCATTGAGGATTTTAAGGATTTACAGGATAAAGATAAAATTTATCGCAAGGGTGATCGGTACCCTAAACCAGCAAACAAAAATATCGATGATGAAAGATTAGAAGAACTTTTAACCAATAAAAACAAACAAGGTAGGCCAGTTATTAAAGAATTAGAGCAAGCATGACGCTTGCTCTTTTTATTCATTCAAATAAACCAAAATAGAGAGGAAGTTTTTTAATATGGCAAATTTAAAACGTAATATGATCGAATTAATTAAAGAGGTTTCAGAGGACGGAGAAATTCTTAAATCAGAAAAACATTTAACACCCGCATTTATCCCGCTTACTGTCGTATATCAAGCAATGGATCTAACTGCCGATATGCAAAAAGCAAATGCTCAAAATGAGAGAGAATTAATTGATCGTTTTGTTGATTTTATTGTTCATGATGTATATAAAGATAAGTTTACAAAAGATGATTTAATTAATGGTCTACATGCTCCAGATGCTATGGAGATTTTACAAAATCAAATTCGTTTTGTGGCTGCTGGTCATCAAAGTGATGAAACAAAAAAGTTTTTAGAGAAGAAGAATTGAGTGATGAAGATTTCACACCAGAAAAGCAAAAAGAATACCTAGATAATTTTATTATGTCCTTAATGAAAGAAGGTAAGGATATTAACCAGGTGTTAGATATGCCCTTTCATTTTGTCTTGGAAATGTTACGTGAGCGAAATAAACCTAAACAAGAAAAATCCTTAATTGCAGCGTTTGGCGCTTAAGGATTTTTTTGTGTTTTCAAGAAGGGAGGGTGAATTTTGGCAGAACGTATTGAAGGTATGTCCATTGCGCTGGAATTAGAAACATTGCAGCTTGATCGCGGTCTAACAGGGTTGAAAGATCGTTTTAAGACTGTAAATAGTGAAATGAAAGCCAATTTATCTGCTTTTGATAGAGGAGAGCAATCCATTGAAAAGTATGAGGTTACTTTACAGGGATTAAGCAAGAAATTAGAAATTCAAAAGCGAATTGTAAGTGAGTCCAGGGCCGAATACGAAAAAATGGTTAAAGAGCACGGGGAAGGATCTAAGCAAGCGGAAGCAGCTGCAAGAAGTTTTAATAATCAAGTAGCGGCTTTAAATAATTTAGAACGTTCCGTTAATCGTACAAGCCACAGCTTGACAGAGTTAAAGCAAGAGCAAGGTGCTTTACAATCTGGTTGGAGCAAGATGGGAAGTTTGATTGATAAAACAGGATCATCTTTAACTGGACTAAGTTCTAAGATGCAAGGAGTCGAATCTACTCTATCTAGCTCTCTAACATTGCCTATTATTGGAGCAGGGGCAGGAATCATAGGACTAGCTACTAAATTCAATGACTCTTCAGTTAAAATAAGTAACTCTTTAGGTACTTCTACTAAGGAGACAAAGAAATTTACTGAAGCCTCACGAAACATTTATAAAGATGGATTTGGGGAAAGTCTGGAAGAGGTAGACAATGCCCTACTGGAAACCAAGCAGAATATTAAAAATATCAATGATGAAGATTTAGAGGACATTACTAAAAAGGCTCTGACTTTGGCTAATACATTTGACGCTGATGTAAACGAAGTAACCAGAGCGGGAAATAGCTTAATTCAAAACTATGGCATGGATGCAAAAGATGCTTTTGATCTAATGGCCAAAGGTGCTCAAAATGGCATGAATTTCTCAAAAGAGATGTTTGATAACATGTCAGAATACACCATTAGTTTTAAAGAGGCTGGTTTCTCTGCTAATGAAATGTTCTCTATCCTTTCTAATGGGGCCAAGAAAGGTTATAACTTAGACCGCTTAAATGATACAATGCTAGAATTTAAGCTTCAAAGTGAGGATTCCAGTAAAGCGTATATGGGTGCTATGGATCAAATGTCTGCAAGCACACGAAAAGTATACGAAGAGTATCAAAATGGTAATGCAACTGTAGCGGATTTATATAAAGCGGTAATACCTGACTTGCAAAAGATGAAAGATACAATTCCAGCAAAAGATTTTAATGTGATTGGGAAAGCACTTTTTGGAACGAAGTGGGAAGATCAAGGGGCCGATGTAGTTTTATCCATGAAAACCGTTAATAAAGAGCTGCAAAACAGCAAGGGTACTATGGATAAAATGACTAAGAATGTAGAACAGTCCTTTGGCGCTCGTCTAAAATCTGTTTGGCGTGAAGCTGGTATGGCCCTGCTGCCTTTCGGGGAGATCCTTATTTCATTTGCTGAAGGTATTTTACCTAAAGTATCTACTGGTATTCAAATGGTATCTGGTTTCATTAAAAGTTTATCACCAGCAGCACAAACAGCGGGCCTTATCTTTGCTGGAATGTTAGCAGCACTTGGCCCTGTAATTACTATGGTAGGTATGTTTGTTGGTGCTATAGGTAATCTTTTACCTGTTTTTACACCAGTAATGAATGCCATTGCACGGGCCGGAGGTTTATTAAATGTTCTAAGAGCGGGGCTTGCTGCTTTAACTGGCCCAGTGGGAATAGTCATAGGTGCAATAACCTTATTAGGCGCTGGATTTGTGGCCTTATATCGCAATTCTCAAACATTTAGAGATGGCGTTTCTGGCTTAATGAGCGGTATACAAAAACTTGGCCAGAGTGCACTAAATATCTTAAAACCAGCTATTGAGTCAGTGAAAAAATTCTTTCAGAGTCAGCTATCCGTAATAAAGCAATTTTGGCAGGATAACTCTACTACTATACTTCAGGCCCTTTCAAATATAGGCAGCGTGGTACGTGTAGTTTTTCAGGGGATTTCTTCTGTAATTGGCTTTGTTATGCCTTTTATACTTTCCATAATTAAATCGGTTTGGGGAAATATACAGGGTATCATAAGCGGAGCGCTAAATATTATTATGGGGCTGGTAAAGGTTTTTTCTGGTCTTTTCACAGGCAATTTTTCAAAAATGTGGGAGGGCTTAAAGCAAATATTTAAGGGAGCTGTTCAATTCATTTGGAATTTTGTGCAGCTGCAAATGTTCGGTAAGCTCCTTTCTCTAGGAAAAGTCTTTATTACCTCTTTCCGTGGTGCATTTGTCGGATTGTGGAATGGTTTGAAATCGTTATTTTCTTCAAGTGCAGGAGCAGCAAAAAATGCTGTAGTGGGATCTTGGAACATACTTAAATCAGTAACGACAACCATTTTTAATACGTACCGATCTTTCCTTTCGGGAATATGGAATTTCTTAAAATCTATGATTTCTAAAACGGCATCTGGAATAGTTAATGCTGTCCGTGGTTCGTGGAATTTACTGAAATCTATAACAACAACTATTTTTAATGCGTACCGATCTTTCCTTTTAGGGATATGGAATTTCTTAAAATCCATGATTTCTAAAACAGCATCCGCAATAGTTAATGCTGTCCGTTCATCGTGGAATTCCTTGAAATCAGTAACGACAAGTATTTTTAATTCTGTCCGTAGTTTCCTAAATTCATTATGGACAGGGGTACAAAAAACGGTATCTAATTTAGCCTCCAGAACAAAAGATGGGGTAGTAAATGCCTGGTCAACTTTAAGAAATAAAACAACTGAAATTTTTACAGGTATTAAAACTAAAACATCTAAAATTTTTGAGGATATAGTTTCAGGGGCAAAAAAATTACCTGGTCGAATTGGTGACGGTATCCGCGCAATGGCGGGGAAAGTAAAAGATGGCGTTTCCGCTCTTGGTAAAAAGCTTGCTGGCGGTCTTGAATCAGTTATGAATACCATTACTCAAAAAGGTATTAACGTTGTTTTAGATAAGATTGGTGTTAGCAAGAAAAGCCAAATTCCTAGATTAGATATTCCCGGTTATGCAACGGGTACTGATTCACACCCAGGCGGGTACTTTTTCGCGGGTGATGGAGGGAAAAACGAATTAATTCGTTTCCCGGATGGACGTATAACAATGAGTCCTGACACTACTACTTTGTATTGGGGAGATAAAGGTACCCAAGTATTAAGCGGAAAACAGACTGATGAATTTCTAAGTATGTATCCAATGTATAAAAAAGGTACGGGTGTTAAGGACGTAGCTAAAACCGCTGGTAAATGGCTTAAAGATACAGGGGGCCAAGCATTAGCCAAAGCGGGAGAAGTAAAAGGAAAAGTGTCTGATTCCATCGGAGATATATGGTCTTATATGGATGATCCTAAAAAGCTAATGAATAAGGTCTTTAGTTCCCTTAATTTGAAAATGCCTGATGTTGGCGGGATAATGGGCGAGCTTGCTAAAGCGGGTGTCACAAAAGTTAAAGATGGCGTAGCTAACTTTATTAAAAAGATGTTCGGTGATTTTGGTGCAAGTGTAGCAGCTCCTGCCGGCAAGGGTGTAGCTAGATGGCGTCCTGTTATTCTCCAAGCTGCCGTAGCTATGAAAGAAGCAGTAACCCCTGCCCAAGTGAATGGTATTCTCGCCCAGATTCAGCGTGAGAGTGGCGGTAACGAAAAGATTGTACAATCATCTGCTGTATGGGATGTAAATACAGCTGCTGGAAATCCCGCTCGTGGATTGCTCCAATATATACCGCAAACATTCAACGCCTATAAGGTCAAAGGGCATAATAATATCTATTCAGGCTATGACCAGTTATTAGCTTTCTTTAATAACACAACATGGCGCAGAGATTTACCGTATGGCCGTAGAGGTTGGGGGCCAAGAGGAAGACGTAAGTATAAAAACGGTACGGGATTACTTGGGCACTTAGGTGGAGACGGTATCTTAGGTGATGGAGGTAAGAGAGAGCCATTCTTAATGCCAAATGGCTTATTAGGTTTAAGTCCAGACAGCGCAACGCTTTATCCTAATTTGCCAAAGGGAACAATTGTATGGCCAAGTATTCAAGATTTCATTAAGGAATACAGTGAGGCAGATGCATCCGTAATTGCTACTAATGAAAATCAAAGAACGGATGCTATGAAGTTATTAGCTTTAGCTGGAAAAGAACTTCAAAGAAATACGCGTTCAAATCCTGTATCTTCTCCTGGTAGCAATACTTCAAGTGCAGATCAAGGTCAGCAGCAAGTACAGTCTATTCATGTTGAAAACCATGTATCTGTTTCTTACTCTGGTTTGCCGAATAGAGATGATGTCATTAAGTTTGCTAAATGGCTGCAAGAGATAATGGACGAACAAATAGAACAACAGTTAAGAGCTAAAGGAGTAAGGTGGGTAGTACATGGCCAGTCTTATTAAAAATTTTGCAGGGGTTAACACCCCTGACTTTTTAATTATAGATAAAGTTCATTTGCCGCCTTTGCCGCCTTCTGAACTAACATCTATTGATATACCTATGAAAAGTGGTTCGCAGTTTGTAAATAAGAAGCATGGAAACCGAACAATAACTATTGATTTAACCATTAAGGCACCTGATCGAGATAAGGTAATGTCAATGGGGGACCAACTAGCCGATTTTTTACAACATGACGAACCACAACCTATTATTTTTCGGGATCTGCCAGGGCGTAAATATTATGCCATTTTAGACGGTGACACGGATCTTGAAAAGATTGAACAGCTAGGAAAAGGCAGCATTAAGTTAATATGCCATGATCCGCATGGATATGGAGAGCAAAGATCCTATAATATTACCTCTGACACTACTATGTTAGTGAATTATGGTAACAGGCAAACAGCTCCACAAATCAGCATGACATTCACTAAAAATGTAACTGACTTTTTTATCGCAACAGATAAACAAAGCCTTTATTTTGGAGAGCCTTTTGATCCAACAGAAAAGACAGTAACGGATACAAAGCCAGTTATTTTAAATGATCCTGGCAGCAGCACAACAGATTGGTTACAAGCAACAAATTTTAATGTAGATGGCGGACGTGTATTAGGTACCATTGGTTCCAATGGTTATTCCTTTAGCCAAGCAGGAAAAGATTATGGTACACTAAGCGGCTTATGGCATGGCGGCAGCATGGTAAGAAGCTTAACAAAGCAAATTCAAGATTTTGAATTAGAATGTCAGGTAGGCTTTTCATCCAGTAATAAAAACCAAAAAGGCAGAATTGAAATTTATCTGCTCGATATTAATAATAATCAGCTTGGAAAAATAGCGATAAGAGACATCTGGAATAACTTAGATAACCCACAGTTTGAATTTTGGGTAGGAAAAGTAAATGGTGGCGGTGTTTCTGTCACAAATACCTACGGGGCCAAAAAAGGTGTATTTTCTGATTTTAACGGGATTATACAAATGGGTAGACTCGGCAAGAAATGGCATTGCTACATTGCAAAAGTTGATTCTAACGGCAGAGCGCACACCAGACACTATAAAGCCTTTACTGATTGGCAAAATAAATATATGCAAAAAGTGGCCAAAATTCAGCTGCATATTGCTGCCTATGATAAAGATCCAGCAGTAGATCAAATGTGGATCAGTAATGTTTATTTTAGGGGAATTTTATCTAAACAATCTAATCAAGTTGATTATGTATTTAGAACAGGTGATAAGCTGCTAATCGATTGTGAAACAGGAGAAATTTATAAGAATGGAAAACTCTTTCTTGAACGGTTATATCCAGGATCAGAATTTTTACTTTTAGATAAGGCAGCAAATGGCCTTGTGGTTTCTGATTACTCAGCTATTAAGGATGGAAAAGTAACCTTTACAGAAAGGTGGCTATAGGTTCTAATGTGGTATATTTTGAACAAAACATATGATGCCGTGGGCGTTTTAAACAATAAGATTCCTAAAGGCTGTCCCATTCTTAGAGATAGCTGGAAAGGTCAGCTAGAGGATGGATATACGACATTAGAGTTTGATGTCTATGCTAGTCACCCACAAGCCAGCTTTTTGAGTAGGGGAGCTTTTATTATTTATACCGATAATCCAGATGGCTATGAGCTATTTAGGATTACAAAGACTACGGAAAGCCACGGGTTAGAGGAAATAAAAACCGTCTATTGTGAAACAGCAGCAACCCAGGATCTAATTGGCCAGATCATTGAGCCAAAGTCTTTTGTCGGGGCCAGCTTATCCGATATAGTTAAATTTCTTTTGAGTAATACAGGATGGGAGTTAGGCGTTTGCTATTATGATGAAATCATTTCAGTAGATTTTGACGATTACCCAACAGCTTTAGAAGCTATCCGAAATACCATTAAGCAATTTGGTGCGGAAATCGAATTTAAGGTGGAATTCGATGGACAAGAGGTTTCCCGGAAAGTTGTAAACCTCTATGAAAAGCGCGGCACAAAAACAGGTGTTAGCTTTGAATATGCAAGGAATTTAGAGGGGTTACGCAAAATTGAGGACGGAAATAAAATTGTTACGGCTATGATCGGTATTGCTAGTAATGAGGACAAAAACGGAAATCCTATTTTACTTATGAATGCTCAAAAGAAACCGCCAGAGGGTTTTGAAGTAGTGGGAAACATGATTGTGGATGTTAATGCCCTTCAGGAATATGGAAACAATGGCGCAAATGTAGTCGATAAATTTATTGATGAAACAGCAACAAATCCAGTAGAGCTTTTTGATAACACAATAGAAGCCTTAAAAAAAGTAAATCATCCCGTTTTTTCATATGAGGCAACAGTCGTAATGATGGAGCAGCTAGAAGGATATGAGCATACAAAATCCTCTATAGGTGACACCATTTATATAAAAGATATATCATCCGAGCCGCCTACTTATTTAGAAGCTAGAATTTTAAATAAAGAATTAAGTACCGTCCAAAAGGATAAAGGATCTATTGTAGTTGGTGAATATGTTCCGCTTACAATTCAACCAATCCAAGCAGTAGAAAAAGCACAGCGTACCCTTCAATTAAAAGAAAAAGTATGGAATGCCACTATTGACCGGGCAAAAGAGGCCCAGGAAGGCGTAGAAGAAGTAAAAAAGCAAGTTCCTTATAAGGTAGAGCTTGTTTCTAGTAACGGCACAACATTTAAAAACGGCCTGATTGATACAGAAATAACAGCTATTGTCTACAAAGGAAAAGAGAATATTACCGATACACTTCCAAAAACCGCTTTTATCTGGACGAAAAAAGATAAAGATGGTTTTTTTGATGTGGCTTGGAATTATGAGCATGTAGGGATTGGTAACAAAATCACAGTTAGTTCGTTTGATGTTGTTCAGCGAGCGGTCTTTACTTGTGATTTAGATTTACCAGAGGAAGAATAAAAAATTAGAAAAGAGTGAAATGACTATGGCGACAGTAGCTACAGGCAGTATGACGTTAATCGATGTAACAGATGCAAAACAACTAATAGCATTTATTGGTTCATCACAACAAAGACAGGTTATTTATAATCCTAATGGCGGCTCATATACACCGAACTATGCTAGTTCAAATAACGTGTTAACACCTCAATTATATATTGCAGGGACTAACACGAATATTGCAGATAAAGCTAAATCAATTAAGTGGTTCTATCAAACAAACAGCAGCGGCAATTTCACTGAAATTACAGCTAGTGATACAAACTATACTTTAGGAACTACAGCACCTAAAACATTAACAATTAAGGGAAATGTACTTGCTTCCGCTAACTCAATGACTTATATGTGTGAGGTTGTTTATACAGATCCAGACACGGGCTTTGATGTAACTACAAAAGCAGAATATGAAATTATTAAAGTAACAAATGGTACTAATGGTTCCAATGGTGCAGCTGGTCAAGATGCTGTAAGAGCTGTTGTGTGGACACCAGACGGAAATGTTACACGTAATTCAAATGGGACTGTCAAAGCAACTGTTGATGTATACAAAGGAGCTTCAAAGGTAACGCCTACAGCTTTTAAATGGTATATCCAAGATCCTGCTGCTACAACGTCAAGCGGTGGGGATGCAGATGGGGGCGCTGGTTGGCGTTTGCTTACTTCTACATCAAATGCAGGAGTAACAGGATATACAACGGATACAATTACGATTCCAGCAAGCGCAATTCCTAGTGTAGAGGCTTTCAAGTGTGTTGTAACATATAACAGCGTGAAATATAACGATGTTTGTACAGTGGTAGATGTTAGTGATCCATATGTAGTTACAATTGTAGGAACAAATACTTTTAAAAATGGGCAAGGAAGCACAACTTTAACAGCTAAAGTATTCCAGGCCGGGGCGGAAGTAGATGCTGCAGGAACAGCTTTTACTTACAAATGGTCTATATATGATGCAAACAATGTTAAAAATACAAACTGGAGTAAAACAGGAAAATCAATTACCGTTACCGCAGCAGATATTAATGTTCGTGGTAATGTAACATGTGATATAGATAAGGCTTGA

Protein sequences of DBSCAN-SWA_2

>NZ_CP018874|2166535:2193354|2184904_2189308_+|WP_078081796.1|tail|DBSCAN-SWA
MAERIEGMSIALELETLQLDRGLTGLKDRFKTVNSEMKANLSAFDRGEQSIEKYEVTLQGLSKKLEIQKRIVSESRAEYEKMVKEHGEGSKQAEAAARSFNNQVAALNNLERSVNRTSHSLTELKQEQGALQSGWSKMGSLIDKTGSSLTGLSSKMQGVESTLSSSLTLPIIGAGAGIIGLATKFNDSSVKISNSLGTSTKETKKFTEASRNIYKDGFGESLEEVDNALLETKQNIKNINDEDLEDITKKALTLANTFDADVNEVTRAGNSLIQNYGMDAKDAFDLMAKGAQNGMNFSKEMFDNMSEYTISFKEAGFSANEMFSILSNGAKKGYNLDRLNDTMLEFKLQSEDSSKAYMGAMDQMSASTRKVYEEYQNGNATVADLYKAVIPDLQKMKDTIPAKDFNVIGKALFGTKWEDQGADVVLSMKTVNKELQNSKGTMDKMTKNVEQSFGARLKSVWREAGMALLPFGEILISFAEGILPKVSTGIQMVSGFIKSLSPAAQTAGLIFAGMLAALGPVITMVGMFVGAIGNLLPVFTPVMNAIARAGGLLNVLRAGLAALTGPVGIVIGAITLLGAGFVALYRNSQTFRDGVSGLMSGIQKLGQSALNILKPAIESVKKFFQSQLSVIKQFWQDNSTTILQALSNIGSVVRVVFQGISSVIGFVMPFILSIIKSVWGNIQGIISGALNIIMGLVKVFSGLFTGNFSKMWEGLKQIFKGAVQFIWNFVQLQMFGKLLSLGKVFITSFRGAFVGLWNGLKSLFSSSAGAAKNAVVGSWNILKSVTTTIFNTYRSFLSGIWNFLKSMISKTASGIVNAVRGSWNLLKSITTTIFNAYRSFLLGIWNFLKSMISKTASAIVNAVRSSWNSLKSVTTSIFNSVRSFLNSLWTGVQKTVSNLASRTKDGVVNAWSTLRNKTTEIFTGIKTKTSKIFEDIVSGAKKLPGRIGDGIRAMAGKVKDGVSALGKKLAGGLESVMNTITQKGINVVLDKIGVSKKSQIPRLDIPGYATGTDSHPGGYFFAGDGGKNELIRFPDGRITMSPDTTTLYWGDKGTQVLSGKQTDEFLSMYPMYKKGTGVKDVAKTAGKWLKDTGGQALAKAGEVKGKVSDSIGDIWSYMDDPKKLMNKVFSSLNLKMPDVGGIMGELAKAGVTKVKDGVANFIKKMFGDFGASVAAPAGKGVARWRPVILQAAVAMKEAVTPAQVNGILAQIQRESGGNEKIVQSSAVWDVNTAAGNPARGLLQYIPQTFNAYKVKGHNNIYSGYDQLLAFFNNTTWRRDLPYGRRGWGPRGRRKYKNGTGLLGHLGGDGILGDGGKREPFLMPNGLLGLSPDSATLYPNLPKGTIVWPSIQDFIKEYSEADASVIATNENQRTDAMKLLALAGKELQRNTRSNPVSSPGSNTSSADQGQQQVQSIHVENHVSVSYSGLPNRDDVIKFAKWLQEIMDEQIEQQLRAKGVRWVVHGQSY
>NZ_CP018874|2166535:2193354|2168643_2168994_-|WP_034652432.1|DBSCAN-SWA
MKYSFGETLKKLRGKITQDQLAKALNDQYGTSINKSMISKWENNKEEPRIDTARFLADYFDVSLDYLLGIEKLNNKKEPTPIQTIAAHLEGKDITEEKMKEVLNYIDYVFSKQFDK
>NZ_CP018874|2166535:2193354|2183467_2184076_+|WP_078081793.1|DBSCAN-SWA
MAEEKKNYHASTGVDEFYYGEVGDGIVASYIERVEYLQTIDVDMPQDITRAYGDNKTAEMAVSNGDIKVTSAFHKIPMEDKQKLLGLEVVDGITYMGSKDNPPYVATIFAKTYEDGSKEYVGLPKGLFTRPKLSGKTKEDGTEFSSEEIEAQFMDRKIDGLDEEKSVAFAVDKKGETTNRDALFMKIFGKPYPGTTTEPAGA
>NZ_CP018874|2166535:2193354|2169428_2169698_+|WP_078081775.1|DBSCAN-SWA
MINVEIDGNEVRELYLKTLKEKIDEVDAELIFWDTKELKRRTCMSWNTIQKEFFFDPRFPKRKVGGKWYIYAPKAKEFLENWLFEQCNL
>NZ_CP018874|2166535:2193354|2178909_2180073_+|WP_172802874.1|portal|DBSCAN-SWA
MRTIGLLDTIFKRDSEIGYMFDVEMFVETANRVHMKKLVLDTCIAFLGRTISQSEFRVKNGKTFVKDELYYRLNVRPNKNMTASTFWETFVHKLIYDNECLIIQSDDDDLLIADDFQHNEYAVFEDTFSNVTVKDYTFKRVFKQSDVIHLRYRNERLTPLIDGLFTDYGDLFGRILSSQKRKNQIRGTVDMDMIGAKSPQHQAKLQEFIDNMYKAIGEKDVAIIPQQPGFKYSETSGGGTTGQSVDEINKVTNGFFNQVAMALGIPTSLVYGDMADIEKQTKNYMLFTINPLLKKLADEANVKFFEQDEYLSGQKIDIKSISYQSLFDLATAIDKLISSSGFTGNEIRLETGYEPSDDPNLDKHYITKNYTEMNKVEGGEEQNDGEN
>NZ_CP018874|2166535:2193354|2169166_2169436_+|WP_078081774.1|DBSCAN-SWA
MYEIKRRHLPYSKLKAYMVENRITQKELSNLLKISAVALNQKINGTGGDFNLNEVRNICRHLKISSDEYFIEPQVSKVKTKLMERVNSD
>NZ_CP018874|2166535:2193354|2172071_2172536_+|WP_078081778.1|DBSCAN-SWA
MENQLSFNLPEIDRKKTQQAVEDVLEQYRLFKYLSFEKREVSITVNPEIRYHGPTYQMSDQTASIASHNVDAEKMRKDFCFRVERAVARLPKMERFLIEERYMTNEADYLTDYNIYCFKFQPPISAMTYSKIRWKAFYRLALNLNIAVTKKSHY
>NZ_CP018874|2166535:2193354|2172541_2173678_-|WP_078081779.1|DBSCAN-SWA
MSTKQPFLEQVLYDNAIDFINKSMQSYLIAEDDNNPKEYKYAILFLATGTELILKSILQNKHPLFVLSNIDSMDDKTVGAEKLIPRINRIYAEDNIRIHNKDAEIFKSIREVRNSIMHKDVRLDVAPNTMYARTLYSLDRIVQQFLNKTLHNQVDNWSLIVDSEAIRKEYYSKVIGYKLGDSHLPCSVCSLEKLLVDQDNPQGLKCFHCNQKYSTVVDAIKSIEDSYLQEELFVSYLHILRSNQVPVDTCPNCGTPDYLQFDSDSNCLICFDCGVIPSSECIKCEKNSAFTYYDEDDNQSSYCVCCKDNPLHGCDLCTTDEYDSAGIYNIDIRDLATFKRHFNDVALKGVFPQIEICENCLKVMYELEKKMIIEFVNP
>NZ_CP018874|2166535:2193354|2183078_2183453_+|WP_078081792.1|DBSCAN-SWA
MLYKVYDALNTSDLIKQKVGKRIKFYEYPSTDNMQGVYIVIDPIDVPKPGDYADNKWLTDEYFYQIEVWSMNLFDTQAVAKEVRNIMWKQLGFAQLIPGLDEFDKDTGIYRDARRYRGKEYVEI
>NZ_CP018874|2166535:2193354|2180056_2180839_+|WP_078081787.1|protease|DBSCAN-SWA
MTVKIDVKGPIISNDEAWIYEWFDIDFTSPKTVIDQLANANGDNVIVSINSPGGYVDDGSEIYTALKAYPGHVETQIVGLAASAASFIATAGDKVVIAPTAKFMIHNASMGNLGDHRSMEKASQMLKTTDRTIVNAYVLKTGKDEQELLDMMAEETWMGPQEALEHNFVDEIMFMDNPIKLTASSAASAMIPQKIIDGFRNGMMNKGKPEGVTKEDLKASLAEFKNEILNELQLNKTNEPKEPTLKPANKRDLSKLFLSL
>NZ_CP018874|2166535:2193354|2174005_2174659_+|WP_078081780.1|DBSCAN-SWA
MNVENIDIIESKVFGLYISELFSLVHVIKRECEEIFKETKEPATGYIMQVSPEIHSKINTVIINSANLKKLLYSPGDKKKKESTKKFKVRKQREALFKELILNLDLEEISNTNVRNKLEHFDEYLDDMTLKLIDEVSEFKKKYPAAVYNMIFSKWEAISPRAYPIRLYITAEKTFYHMDWSINLGKIYKEAKLILERLENSDLLPDEKPGGLIVKFQ
>NZ_CP018874|2166535:2193354|2176664_2178323_+|WP_078081784.1|terminase|DBSCAN-SWA
MISNKYVDEYIHLYETGEIKLNKERIMLIKYLQKHVLVRDDIYFNEEMVENYIKFTEKWYFKLQPFQKFIAPFVFLYYKEDDSVFYDQFFITMSRGGGKNGFISSLSHFFISPLHGIPKYNISIVANNEKQAKLSFKEVYDCIENNEVLEDLFYRTKVEIMGYDTKSIMQYHTSNASSKDGLRDGCVIYDEIHRYENFDVVNVFSSGLGKVPNAREFFIGTDGYVREGFLDKMKERAMNILEGKDLDDPLFPFICKIDEAKEVNNPDMWEKANPMFSEPRSSYAKGLFKKVLRQFKQLVNNPSNREEFMTKRMNFPETDLSKSVASWEEIWRTGYEEDGKTLRKVPDLKHRVAVGGLDFASIKDFAAVGLLFKVGDDYIWKSHSFVRKGFLDKVKLKAPIKEWEEKGLLTILDEPVINIKHIVDWFVEMRELYGVNTIVGDTFRLDLVKTALEAEGFILLYIRNPKAIHSLLAPRVETLFANNHIIFGDNPMMRWYTNNVLVKIKPDGNKEYLKKDEFKRKTDGFQAFIHALWQADNLLTDELDFMLSNIKF
>NZ_CP018874|2166535:2193354|2169711_2169885_+|WP_172802873.1|DBSCAN-SWA
MKFIEAIQSQLLWNKEQIKRLRVELLTSDTPIAIEKLIYGYEQQNLALSFVLEMAGE
>NZ_CP018874|2166535:2193354|2184079_2184271_+|WP_078081794.1|DBSCAN-SWA
MASNRKFEVIEDFKDLQDKDKIYRKGDRYPKPANKNIDDERLEELLTNKNKQGRPVIKELEQA
>NZ_CP018874|2166535:2193354|2190755_2192252_+|WP_078081798.1|tail|DBSCAN-SWA
MWYILNKTYDAVGVLNNKIPKGCPILRDSWKGQLEDGYTTLEFDVYASHPQASFLSRGAFIIYTDNPDGYELFRITKTTESHGLEEIKTVYCETAATQDLIGQIIEPKSFVGASLSDIVKFLLSNTGWELGVCYYDEIISVDFDDYPTALEAIRNTIKQFGAEIEFKVEFDGQEVSRKVVNLYEKRGTKTGVSFEYARNLEGLRKIEDGNKIVTAMIGIASNEDKNGNPILLMNAQKKPPEGFEVVGNMIVDVNALQEYGNNGANVVDKFIDETATNPVELFDNTIEALKKVNHPVFSYEATVVMMEQLEGYEHTKSSIGDTIYIKDISSEPPTYLEARILNKELSTVQKDKGSIVVGEYVPLTIQPIQAVEKAQRTLQLKEKVWNATIDRAKEAQEGVEEVKKQVPYKVELVSSNGTTFKNGLIDTEITAIVYKGKENITDTLPKTAFIWTKKDKDGFFDVAWNYEHVGIGNKITVSSFDVVQRAVFTCDLDLPEEE
>NZ_CP018874|2166535:2193354|2184326_2184683_+|WP_034652352.1|DBSCAN-SWA
MANLKRNMIELIKEVSEDGEILKSEKHLTPAFIPLTVVYQAMDLTADMQKANAQNERELIDRFVDFIVHDVYKDKFTKDDLINGLHAPDAMEILQNQIRFVAAGHQSDETKKFLEKKN
>NZ_CP018874|2166535:2193354|2184679_2184868_+|WP_078081795.1|DBSCAN-SWA
MSDEDFTPEKQKEYLDNFIMSLMKEGKDINQVLDMPFHFVLEMLRERNKPKQEKSLIAAFGA
>NZ_CP018874|2166535:2193354|2180857_2182009_+|WP_078081788.1|capsid|DBSCAN-SWA
MTIKFNKSEAMNEAKSKLAAVLTNTESTEQEQTAAFQTYFDTLQHEVANNVRKQVNDEMLDRSILQQRGQNVLTSAEMKFFNAVVQDGGFKDDSILPETTQERVFEDLVTEHPLLDALGLQDLGAVTRFIYSDPEGAAVWGPLFGEIKGQINAAFHEKQIGQLKLTAFAAIPDDMLQLGPVWVERYVRTVIVEAYAVGLENGFVNGNGNNQPVGLLKDVNAETGAVTDKASSGKLTFKPGRTTVIELKDVVKGLSKNAKGKNRKVAGKIVMVVNPFDNFDIQASATTQNANGVYVTNLPFNPQIVESEFVPEGKVIFFVKGEYIAAVAGNYQLKKFDQTLAIEDAILYTIKRFANGLPKDNKASAVYDLEIDESLEAEAPAGA
>NZ_CP018874|2166535:2193354|2174817_2175621_+|WP_078081781.1|DBSCAN-SWA
MPEKQTCFIITPIGSDDSSIRRSADGVIDAVIAPILEEMDFEIIVAHRMNEGGSITRQVIQNIIDAELVIANLTSLNPNVMYELAVRHAIRKPLVQICEKGTVLPFDISEQRTIFYTNDMKGTVELKAAFEGMVNEALRDEKPDNPIYRAIQSEIIIKDTEVGDTDKYLVRRMDELESKIVSTLYNRDVIKLNPQRYNELSFNLDGSEIRIAEKIISKMLHEQNGRALKIEEVQEALSNEVDIYLSNDILQKVIKKVRNEFKRSLPL
>NZ_CP018874|2166535:2193354|2176332_2176668_+|WP_078081783.1|DBSCAN-SWA
MAKIKRETLRKRIEKDLRNQLSEKKIVGNHYEDLVQDYLSLWDLKCNLIEDIETNGIKVTGMHGPKSNPSINDLHKTNDRMLKILDALRLDASPEEKNSSSKPKRSVKDLV
>NZ_CP018874|2166535:2193354|2175875_2176196_+|WP_078081782.1|DBSCAN-SWA
MKKYITKRQKLRFYKSKEWKALRLEVLKRDNYECQECKRNGLVYTDKHDPEKHKRLDVDHLKEIENYPELALDIDNCEVKCVRCHNKKHNRFQKRRKKIFWDDEKW
>NZ_CP018874|2166535:2193354|2166535_2167660_-|WP_172802893.1|integrase|DBSCAN-SWA
MIRLASYRQRGKKWEYRIRYVDPACGKTKEISKGGFRTKSEAKLAASELEKQIYLGKHSLLENREKLIKDWFNEWLEVYGSQVQLRTLKNRKTYVNNQIIPYLGDFKLNQLPRLEYQKFINRLTENYSLGTVKAIHSIFCIAINKAVELEMLTYNKYRNISIKKEKDLSERKINYLTRDEVTIFMDTAKQCPFYQYIVAITLLRTGMRKGELIALHWDDINFKDKTISITKTRSSHGVKPPKTKRSMRTISIDETLVTELKKYQTWQKRNKLKYGANYIEQEYMITQANGKALSEFRINDIMKAITNKAKLHHISPHGLRHTHAIMLLESGADIKFVSDRLGHTNIKMTADVYLHITKKYESENITKLDRYLSN
>NZ_CP018874|2166535:2193354|2182686_2183079_+|WP_078081791.1|DBSCAN-SWA
MSVQIKGLSNLLADLEKRLGPTKVKSISEQALKEGAQVFVKELKTQFESFKDTGASIDEITISESEYVAGVRTIKIHWRGPKDRYRIIHLNEWGTVKNPNPKGKGAIARAMRNAENAYKAAVREAVRRGI
>NZ_CP018874|2166535:2193354|2182321_2182690_+|WP_078081790.1|head,tail|DBSCAN-SWA
MQPFKYTPPRIHTGELKTWVTFYEAKENDGPLPGENPRNVLYECWAKVDEVWTKDIEIAKSNGTLSDLTISIRDPRGDYSPTNKHYVQVHSPEYEDLKYNIKQAFPDLQNRDFIKVIAEVSK
>NZ_CP018874|2166535:2193354|2170187_2170868_+|WP_078081776.1|DBSCAN-SWA
MKELVSIQNGQAVTDSLTVAEVFGKRHDSVMRDIRNQRVKLIEAGMEEFIFHNFVEREYQSQQGNFYKKYELTEDAFAVVAMSYITPEAMKFKVEFLQEFKRIKAELQGKPKILTEREQLVASMKLSIEAVEEIPAIKKEVTDLKRVFSEELTLNHGQQQSLHHEIKKRVESLIGDYQECGFTKQRMYSEIHKNLRRAFSAPKYIFVKRKDYQEAITWVKAWRPLL
>NZ_CP018874|2166535:2193354|2192277_2193354_+|WP_078081799.1|DBSCAN-SWA
MATVATGSMTLIDVTDAKQLIAFIGSSQQRQVIYNPNGGSYTPNYASSNNVLTPQLYIAGTNTNIADKAKSIKWFYQTNSSGNFTEITASDTNYTLGTTAPKTLTIKGNVLASANSMTYMCEVVYTDPDTGFDVTTKAEYEIIKVTNGTNGSNGAAGQDAVRAVVWTPDGNVTRNSNGTVKATVDVYKGASKVTPTAFKWYIQDPAATTSSGGDADGGAGWRLLTSTSNAGVTGYTTDTITIPASAIPSVEAFKCVVTYNSVKYNDVCTVVDVSDPYVVTIVGTNTFKNGQGSTTLTAKVFQAGAEVDAAGTAFTYKWSIYDANNVKNTNWSKTGKSITVTAADINVRGNVTCDIDKA
>NZ_CP018874|2166535:2193354|2178515_2178833_-|WP_078081785.1|DBSCAN-SWA
MDMVLKVCISDGSEIIIDGFDKIAFHNELPNPDIYHSGYSWQKDYYYELLNNLVKYNFISIQRKDPNDKLEYRNHAFAFKNTNFNSNNPLILRTNCISTIINMYL
>NZ_CP018874|2166535:2193354|2170980_2171928_+|WP_078081777.1|DBSCAN-SWA
MAKYRQVHTTFWQDPKVLEEMTPEDKYFYLYLLTNPNTTQIGVYQITKKQMAFDLGYSTESINSLLHRFITLHKLIKYNEQTRELAILNWGKYNLHKAGKPVIDCVNKELKEVKDKTLLLDIMNHIPNDSVLQAFSRHVDDTYNDTSTCRGQEKEEEKEEEEEKEKEEKKKKGSSTAFEFYEKNFGLLSSHLIQEINAWLNDFNGNHEVVIEALKISVERNKRNWGYTKAILKDWYSKGVKSLLDIKALEIEFKKKSLSTKTKIVRREVVPEWLNNNNKIEEKVTSEYDPSFEEEKRKLEADLKALNEELKGKSL
>NZ_CP018874|2166535:2193354|2167731_2168013_-|WP_172802872.1|DBSCAN-SWA
MRFKDVTAERKTFVSCFKNQSKDTNTIKIFSNGVTKIIYSSCEKSEKVSISDLKRDVKQSEVSYAIKKILKAQPASVEIFYSANGVIHIHKNN
>NZ_CP018874|2166535:2193354|2182023_2182335_+|WP_078081789.1|DBSCAN-SWA
MEITDKLLQEFKDRMHFTHNFTHKGEDSNLKELLSFSIDDITRKVGAFNIEENKGAKELVFERTRYAYNDALEYFDKNFQSQINSVGFSIAMETKEGDPDAAV
>NZ_CP018874|2166535:2193354|2189291_2190749_+|WP_078081797.1|tail|DBSCAN-SWA
MASLIKNFAGVNTPDFLIIDKVHLPPLPPSELTSIDIPMKSGSQFVNKKHGNRTITIDLTIKAPDRDKVMSMGDQLADFLQHDEPQPIIFRDLPGRKYYAILDGDTDLEKIEQLGKGSIKLICHDPHGYGEQRSYNITSDTTMLVNYGNRQTAPQISMTFTKNVTDFFIATDKQSLYFGEPFDPTEKTVTDTKPVILNDPGSSTTDWLQATNFNVDGGRVLGTIGSNGYSFSQAGKDYGTLSGLWHGGSMVRSLTKQIQDFELECQVGFSSSNKNQKGRIEIYLLDINNNQLGKIAIRDIWNNLDNPQFEFWVGKVNGGGVSVTNTYGAKKGVFSDFNGIIQMGRLGKKWHCYIAKVDSNGRAHTRHYKAFTDWQNKYMQKVAKIQLHIAAYDKDPAVDQMWISNVYFRGILSKQSNQVDYVFRTGDKLLIDCETGEIYKNGKLFLERLYPGSEFLLLDKAANGLVVSDYSAIKDGKVTFTERWL
>NZ_CP018874|2166535:2193354|2168155_2168629_-|WP_078081773.1|DBSCAN-SWA
MLSSYEKLQSKYSNIPMNEIPLMHGFKGLYYDGRILIDKNLDETEKYCILAEELGHHFTTVGNILNQDNLVNRKQEKLARRWGYNEILFLSRLIEAFHNNCTNRYETASFLNVTEKFLQEALDCYKEKYGVCTFYDGYLIGFDPLIIEKLPLNSDSN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2159893:2159908	attL	NA	NA	NA	NA
WP_172802893.1|2166535_2167660_-|integrase	site-specific integrase	S5MBZ0	Brevibacillus_phage	3.5e-68	40.3
WP_172802872.1|2167731_2168013_-	DUF1827 family protein	NA	NA	NA	NA
WP_078081773.1|2168155_2168629_-	hypothetical protein	A0A0K2CZC9	Paenibacillus_phage	2.6e-33	50.7
WP_034652432.1|2168643_2168994_-	helix-turn-helix transcriptional regulator	A0A2I7SC14	Paenibacillus_phage	1.4e-23	51.3
WP_078081774.1|2169166_2169436_+	helix-turn-helix transcriptional regulator	A0A2I7SC17	Paenibacillus_phage	3.9e-18	50.6
WP_078081775.1|2169428_2169698_+	group-specific protein	S5MC08	Brevibacillus_phage	6.4e-29	66.3
WP_172802873.1|2169711_2169885_+	hypothetical protein	NA	NA	NA	NA
WP_078081776.1|2170187_2170868_+	Rha family transcriptional regulator	A0A0S2SXM6	Bacillus_phage	1.1e-43	49.3
WP_078081777.1|2170980_2171928_+	DnaD domain protein	D2XR43	Bacillus_phage	9.2e-62	49.0
WP_078081778.1|2172071_2172536_+	transcriptional regulator	A0A0S2SXN1	Bacillus_phage	4.5e-62	78.8
WP_078081779.1|2172541_2173678_-	hypothetical protein	NA	NA	NA	NA
WP_078081780.1|2174005_2174659_+	hypothetical protein	K7PJU1	Enterobacteria_phage	7.8e-36	42.8
WP_078081781.1|2174817_2175621_+	hypothetical protein	C9E2Q0	Enterococcus_phage	7.8e-30	39.0
WP_078081782.1|2175875_2176196_+	HNH endonuclease	A8ATF8	Listeria_phage	2.7e-34	67.0
WP_078081783.1|2176332_2176668_+	hypothetical protein	E2ELI1	Clostridium_phage	2.3e-12	40.2
WP_078081784.1|2176664_2178323_+|terminase	terminase large subunit	A0A0U4B089	Bacillus_phage	5.6e-264	80.1
WP_078081785.1|2178515_2178833_-	hypothetical protein	NA	NA	NA	NA
WP_172802874.1|2178909_2180073_+|portal	phage portal protein	A0A2H4JAJ1	uncultured_Caudovirales_phage	1.1e-178	78.0
WP_078081787.1|2180056_2180839_+|protease	Clp protease ClpP	A0A0A7RWX3	Clostridium_phage	5.3e-55	55.6
WP_078081788.1|2180857_2182009_+|capsid	phage major capsid protein	A0A2H4JH29	uncultured_Caudovirales_phage	4.1e-141	69.3
WP_078081789.1|2182023_2182335_+	hypothetical protein	A0A059T7R0	Listeria_phage	3.8e-25	59.6
WP_078081790.1|2182321_2182690_+|head,tail	phage head-tail adapter protein	G4KNQ4	Staphylococcus_phage	1.0e-24	46.8
WP_078081791.1|2182686_2183079_+	hypothetical protein	A0A2H4JB89	uncultured_Caudovirales_phage	1.7e-30	48.8
WP_078081792.1|2183078_2183453_+	hypothetical protein	A0A0N9SKI2	Staphylococcus_phage	5.8e-20	39.8
WP_078081793.1|2183467_2184076_+	hypothetical protein	A0A2H4J4E0	uncultured_Caudovirales_phage	4.7e-51	53.8
WP_078081794.1|2184079_2184271_+	hypothetical protein	A0A2H4JA77	uncultured_Caudovirales_phage	1.2e-10	53.3
WP_034652352.1|2184326_2184683_+	hypothetical protein	A0A2H4J5B3	uncultured_Caudovirales_phage	1.2e-19	44.8
WP_078081795.1|2184679_2184868_+	hypothetical protein	A0A1D6Z284	Staphylococcus_phage	7.0e-06	48.1
WP_078081796.1|2184904_2189308_+|tail	phage tail tape measure protein	X2KQI5	Enterococcus_phage	1.9e-61	45.1
WP_078081797.1|2189291_2190749_+|tail	phage tail family protein	NA	NA	NA	NA
WP_078081798.1|2190755_2192252_+|tail	phage tail protein	U5J9M3	Bacillus_phage	6.4e-25	53.9
WP_078081799.1|2192277_2193354_+	hypothetical protein	U5J9M9	Bacillus_phage	1.3e-125	67.0
2199116:2199131	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_CP018874|4170566:4179866|DBSCAN-SWA
ATTATATCTCTCCTTGACGAAGCAAACGAGCTAATTCTAATTCCCAGCCTTGAAATGTCCATTGCTCCTGCTCACCATTTGTTTTTTTATAGTTTTCTAAATCCAAGCCGCAGCAATCGCAACAATTCTCAAGCTCTGATTTTCCCGTTTCATCGAAATAGCCAAGCAGCACGTGACGACGGCATTCTTTTGTCTCAATAAACCCCTTCATCGCACGGTACTTGTCATGTTTGTTTCGAAGACGTTTATTTACAGCTGTAACAATCGTTTCATGCAGCGATTCAGGAATTTTCCAGGGTTCAACATGTTCATTTTCCACTGCATTTTCTCTGTACAAATAATAACGAATAAATCGCCAATGTGTTTCTTGAACACCCACTGTATAAAGAAAGTGAGACTCTACTTGTTTTAAAGGAATGGCCTGATCATGGTTTCGTAAATACGACAAGCAGTATAAGATGGTATCTGAAGAAGGAAGCTCAATTTCAAGTAAAGAATGAGCAAAATCATCGTCTCCTTCAGTATAAAGCAAGATCGCAATACTGTTTCGCTGATCGCGTCCACTTCTTCCAATTTCCTGTACATATGCTTCTAGCTGCGTAGGTGTATGAAAATGAATAACAAAGCGAACATTCGATTTGTTAACCCCCATTCCAAATGCACTTGTGCAGCAAATGATATCAAGCTGATTTTCTAAAAATTGCTGTTGAACAAGCATTCTTTCATTCGGTTCCATTCCCCCATGGTAATACTGCACTCGCTGTATCCCATTTTCCTTTAGAAGCTGTGTTAATGCTTCTGTCCAAGATCGGCTGGAACAATAGATAATTCCCGGACCTTGCAGTTCACTAACGTACATCAGTAACTTCTCTTTTTTTTCTTCAATACTTGCAACAAAATCAACTTTCATCGCAATATTACTTCGATTCATGGAATAGATGTGCTCGTTGACAGCAGGAAGCGATAAGTAGCGCTTAATATCTTCCACTACTTCCCTAGTCGCAGTTCCCGTTAATGCCAGACATAGCGGACTGCCAAGTTCCTTCCATATATCTCCTAGCTGTAGATAATCTAAACGAAAATCATGTCCCCACTGAGAAATACAGTGCGCCTCGTCCACAACGAAAAGGCCTACCTTTGCCTGCTTTAATGCTTCTACTACAACAGCATTTTGCAAAATTTCAGGAGATGCATAAATAAAACGATAAAAAGCTAAATTTTTTAGCGCTCGTTGTTTTTCTTCTTGTTGTAGGAAACTATTTAAGGCAATAACTCGCTTTTCTCCGCTTGCCTTTAGTTGTTGAACTTGATCTTCCATCAGTGAAATTAAAGGAGATACAATCAGCACCGGTCGGTTCAACAAATAAGCTGGGAGCTGATAGCACAATGATTTTCCTGTTCCTGTAGGAAGAACCGCTAACACATTATGACCCGTTAAAATATCTTGAATAATCTCTTTTTGTCCTAGTCGAAATTGGCTATAGCCAAATTGTTTCTGTAGAAGTTGTTCTATCTTCACATCAAACACCACTTTTTTTAGTATCAGGTAAAATGTTTTGCTAATACGAGACGAATCTGAAAATAGGTAACGTCGTCTTTTACTTCTTCCTTTATCACCTTTAATTTATTTGTACGCAAACCTTCAAAGGCTGAGACAATTTCTTCCTGCTGCTTAGGCGATACGTATGCATCGATTGAAAAAGATGGAACAAACAGAGCTAATTCTGCAATATGATCTTCAATTGTACTTTCTTTTAAACGCCTTATATAAGCAATTTCTTCAAGCGTCTTGCCTTTTTGAAGCCAGCTATACGTTTTTAACGTCGAGCTTGTCAAAGGCAATTCTAAATATAGATCACGTAAAAAAGAAGAAAGTACATGAAAGCTTTCATTATTTTTACTCACTTTTTCAATGATATGGTGAATAACCCCTAAAAGTTGAATATGAACATAATGCTCATCGAGTTCATATTGATATGCTAACTGATTTTTTGTAAAGCCTACTCTTTGGTATCCAGTCAGTTGCAAAACAAAAAGAGACGCGTCCCGTTCCGTACAACCTTTCAAGCACGTTCGGAGCTCTTCGAATAGCTCGGCCGCTAACTCTTGACGCGTTTGCTTTTGAGACATAATATACGTTTTGACCCATTGAATAACCTCAGGATTTTTGGAAATGGGTAAAAACCCTTTTTGAAAATACTGTAGGTTTGATAAGGTCTGAATGAACAAAGTGATTCTTGCTAAAAATAATTGAGTACTGCTTGCGAATTTCCATCCGTCTAAAGCTGGATGAAAGGGTCGAGCCGTCAGTTCATCTTCAAGGCGTGCTTGTCCCTTATCTGTCATCACATACTTTTGATTTTCAGTTTCTTCAATATACTGCTGTTCTTTTAAATATGCAACGCAGGTTTCAAAAGACCGTTTATCTAAGTAAACAAATGACTGAAAAAGAAACGAAATTCCAAAAATTTTTCCGTCTTGAATCGTTTGAGCTGACTTTTTACCTGTTAATAAATGATAAATACCATAGGCGGTTCGCTCACCTTTTAACTGTTTTATACAAAATAAAATGCTAACTTGAATATAATTCAAAGGTGTCAACTTCCTTTCTCATTCATTGTACCAAAAGTGACCAATAGCATGTGAGATAAAGGCTTTTTAGCTCTTTCCTTTATGTATCAAAACGTTTGGGTAAGTGAAGAAACCTTGATTTGATAAGCATTCTCAGTGACTTTTCTATTGAAAAGTTTTATAAATCATTTTACAATGAATAAGGAGAAATTTCACTCTTGATTCGCGAAGAGATTATATAATGAGAAATTTTCGAACACTTTACAGGAGGTCTTGTTATGCCAAAATATACAATTGTTGATAAAGATACTTGCATCGCATGCGGCGCTTGCGGAGCAGCAGCACCAGACATTTATGATTATGATGATGAAGGTATTGCATTCGTAACATTAGATGATAACCAAGGTGTAGTAGAAATTCCAGAAGATCTAGAAGATGATATGATGGATGCAATGGAAGGCTGCCCTACGGATTCAATTCGCGTAGCGGATGAAAAATTCGAAGGCGATGCTAATAAATTCGAATAAGTATTGAGCAAACCTGTAGTGTACATGCTGCAGGTTTTTTTATATATAAAAATCGCTCTCCCCGGGAGAGCGATTGAATTAAACAGCAATGCGACGCGTGATCCATTGCTTCATTTTTGAAAACAATAAGACAAAGATAACCCCTGTTGCTGCTCCTTTTATTAAGTTAAACGGCAAAATACCTGCAACGATATATTGACGTGCTTGTTCACTAGACATTTCTGGCGATTGTAAGAAGATTGTATACGCTGGTAAGAAGACATAATAATTTAAGACAGCCATGAGTACCGTCATTAACACCGTACCCGTAACCAAACCTATCGTTACGCCTTTAGCCGTTTTAAATCGGTTGAACATGTATGATACAGGAAGAACGAACAGTAAACCAGCCACAAAGTTCGCCACTTGACCAACTGGAACCCCTGTAGCACTTCCTTGAATTAAATAATTCAATAAATTTTTTATTCCTTCTACTATAACAGCAGCCATCGGTCCGAATACAAGTGCTGCTACGAGTGCAGGAATTTCGCTAAAATCAATTGTTAAAAACGGAGGTAATCCAGGAATTGGAAAGTTAATCATCATTAAAATATAAGCAATACTACTTAACATTCCTAGTACAACCAGCTTTTGAGTTTTCTTACTTTGTTGCATCTTGCCTCTCTCCTTCTTTGTGATCCACTCTTCAAAGAAGAAAGGTTCAACTTTATATCCCCACGCAAAAACCTCCCAACAAATGATTCGTTGAGAGGAGACATGGCAGGCATATTTAATAAACGTTCATCACATTAGGTTTTGAACGCTGAACCTCCACCTTCTCCCATCCAGACTGTACTGTCGGCTTTGGAGTTTCACCAAATCTGCTCGTATGTATTACATATAAGCTCGCGGGCTCAAAACAATTTGTTTTTTACCGCCGGTCGGGAATTTCACCCTGCCCCGAAGATAGACCAATATTTAATTATGAATTTATTATATGTTATCTCGAATTAAAAGTAAATAAAGAAGTTTTTTAATTCCTATTAAATTGATGCCTTTTATAAACTTCATTACTGTTTTTATATGTAAAATAAGTAAATAAGTGCATAACCAACAGCATTATGACATATTTATAGTTCCAATTTACGTTTATAATTGTGTATTTGATAACTAATCGTAAAGTTTGAAAAATACAATTGACAGAATTTTTTTAACATGGTAAATTATCAAATATTTGATGGTAGTAAAATCCAAGGGAGATGTTCACGTCATGTATAATGTGTTAGTAGCTGATTCAATTAGCAATGAAGGTCTTGCTCCACTACTTGAAGCTCCTCATGTGAATCTTACGCGAAAAAAAGTTGAAGAAGTTGAGAATGATTTGCATACGTACGATGCGCTTTTAGTACGGAGTGCTACGACGGTTACAGAGGATTTGCTGACAAAAATGCCGAATTTAAAAATTGTTGCTCGCGCTGGAGTAGGGGTCGATAATATTGATATTGAAGCCTCAACTAAACGAGGGGTTGTCGTTATTAACGCGCCGAACGGAAATACCATTTCAACGGCGGAACATACATTTGCTATGATGGCTAGCTTGTTTCGTCATATCCCCCAAGGAAATGCTTCAGTTAAAGCGCGCGAATGGAACCGCTCAGCATTTGTTGGAACAGAGCTTAATCGCAAACACCTGGGCATTATCGGATTTGGACGAATTGGCTCAGAACTTGCCAAACGCGCAAAAGCCTTCAATATGAGCGTTCACGTTTACGATCCTTTTTTAACCTCTTCCCGAGCTGAAAAGCTAGGAGTAGAACTATTATCCCTGGATGAATTACTAGCAGCAGCGGATGTAATTACCGTGCACACTCCGCTTACGAAAGAAACAAAGGGATTGCTCAATCATGACACATTAGCCAAAACAAAGAAGGGTGTGTTTTTATTAAACTGCGCGCGCGGCGGAATCATTGATGAAAAAGCCTTAGTTCATTATTTAGAAATTGGCCATGTTCAAGGTGCAGCTATTGACGTATTTGAAGTTGAGCCGCCGATTGATAACCCTTTGTTACATTTTGATCAAGTTATTACAACTCCCCATTTAGGAGCTTCTACAAAAGAAGCCCAGCTTAACGTTGCTGAGGACGTGGCACATGACGTTCTGCGTTTTCTAGAAGGTAATCCTGTAAGCTCATCCATTAATTTGCCAACGCTTTCTAAAGAAGTTTTTGAAAAAATTCAGCCGTTTACGAGCCTTACTAAACAAATGGGAGCCATTTTATCTCAATGCATGCGAGAACCTGTTCAGCATATCTCTATCTCCTACGGAGGTACAGTGACGGATTTGGAAACCACTTATATTACACGGAGCTTGCTATCAGGCTTTTTAACTCATCGGATCGACTCACCTGTTAACGAAGTCAATGCTTCTATGATTGCCAAAGAACGAGGAATTACATTTGGTGAAAAAACATCGGAAGATACGCAAGGATATTCCAATATGATTGACGTTACCGTAACAGGGGAACAGCGTATATTTACCATTACGGGCACCTATATAGCAGGCTATGGACCTCGAATTATTAATATTGATTCGTTTGATATTGATTTTTATCCGGAAGGACATCTTCTTTATATCCGTCACAGTGATCAGCCCGGAGTTATTGGAAATGTAGGGAAAGTACTTGGAGATTTACGTATTAACATTGCTACCATGCAAGTGGGCCGTAAGCAAAAAGGCGGAGAAGCCATTATGATGCTTACGTTTGATAAACTTTTAGATGATTCTGTCATTTCCTCGTTAAAACAAACAAGCGAAATTGTGACCATACAGCGTATTGAATTGTGACATTAAAAAAAGAGCCTTAGCGGCTCTTTTTTTATGGACTTATCTTTAACACTTGTCCTGCATTTAACATCGTATTTTCTAAATGATTCCACTTTCTTAGCTGATCAATATCTACTTCATATTTGACTGCGAGCTCAGATAATGTATCTCCTTGATGGATAAGAATACAGTTATCAGAAGTCTGATGTAACTGCTGAAAAACCGTGGCAGCTAAATCGCTTTTTACGTATGCCGATAGTTTTTGCTTGTCCAATTTGGCAAGTGGGTTTACTGCATTGGTTTTATCCGGATTCCAACTTTCTTGATGAACTTCAAAATGCAAATGTGCACCTGAAGATCGCCCTGTATTGCCAACTCGTCCAATGTTTTGACCTGCGGCTACACGATTTCCTTCTGCAACAAAACGTTCCTCTAGATGAGCATAGACCGTTTCGTATCCATTTGTTTGTTTGATAAAAACAACCTGTCCGTATGTATTTGAATAGTAAGAGCGGCTCACCACTCCTTTTGCAACAGCATACACCTGTGTACCAACAGGTGCTGCTATATCAATTCCAAAGTGTTTGGCGTGACGAGAACCAAATATATCAGTTAAGACTCCTTCAACCGGCCACTCCCACTGCTTCTCTTCTGCTTTTACCATTTGCCCGCCCAAAAATAAAAGACCTATACACAATCCCATTACTAATACAACCAATATTCTTCTTAACACGTCAATCATGAAGAAAGAACCTCCTATGTAGATCATTGCACACAAAACATACTATATGCCAATTCCTTCTCTTTTAGACTTGTTTATAGAAAAAATAAAGAGATGTGATTTTCCACTGAATCACATCTCTTTGCTATTCTTATTATTTCAGCCGAACAAACTGTTATTTAGCATGTGCTTACTTTGGCAGTTTAATAAAGAAAGTTGTTCCTTCATTTAATTCACTTTCAACCGCAATGATCCCTTGATGTGCCTCCACAATATTTTTGGCGATTGCAAGCCCAAGACCAGTTCCTGACTTCCCTCTTGTTCTGGCTTTATCCGCTTTATAAAATCGTTCAAATACAAATGGAAGATCTTCTTTCGGAATGCCTGCTCCTGTATCTTGAACAGAAAGATGGATTTCGGATTGACTTTTATCAAGATGCAGCTTTACTTCTCCGTAGTCATCCGTATGACGAATCGCATTATCAATTAAGTTTGTCAGCACTTGTTCCATACGGTCTGAATCAATCATCGCTTCAAATTCATCTTCTATTTTTCCATTAAGAGACAGTTTAATATGTTTTTCTTTAGCTAACCCTTGAAACTTACGCAAAACACGTTCTGTAAATTCAACCATTGCTACAGATTCTAAGTGAAGCTGCACATGTCCCGCTTCCATTCGCGCCAAATCTAAAAGTTCATTTACAAGCCGGCCCATACGGAGTGATTCATCATAAATCACCTGTGCAATTTCTTTCTTTTCTTCATCCGTACTTGCAATATCGTCAATAATAGCTTCACTATAACCTTGAAGCATAGAAATAGGTGTACGCAATTCATGAGACACGTTTGCAATAAAATCTTTTCTCGATTTATCAAGTTTACGCTCTTCAGACATATCACGTAGTACAGCTACAGCACCGCGAATTTTCGTTTGATTATAGAGCGGTGACATTAAAATGACCCACGTTTTCCCTTGAATTTTCAATTCTGCACTTCGCTCCGTTTCAGTCTCTACTACCGTTTGAAACAAATGGACGACGTTTGCTGGAAGCTCAGGGACCTGCTGATTGTTGACATCCTGCTCGTAATACCAAGTCTGAAGAAAATGCTCCGCTGGAGGATTGGTAATTAAAATCGATCCGTCTCTACTAAACGTAATAACACCGTCTGCCATACTGCTTAAAATACTTGAAAGCTGCTCTTTTTCCTGATTGAGCGCATTGAGGTTAAACTTTAACTGCCTGCCCATTTGATTAAAAGCAATCGCTAACTCTCCAATTTCATCGTGAGTTAAAATAGGTACTTTTGTATCAAAGTTGCCTTTTGTTACTTCAAATGCCGCCTGCCTCATTTTTCTAAGAGGCGCTGTAATTCGAGTGGATAAGAAAAAAGCAAAGATAGTAGTTAAAATAATAGCAATACCTGCAGCCAATAAAATGAACTTAGTCGTATATTGAGCGGGTTCTTCAATTTCAGAAAGAGATTGATACAAATAAACGCCGCCTGTTGGTTTGTTATCTTTCATTAAAGGTACACCGACAACAAACATTAAAGGCTCATCACTCGTGTCTTTCTTTGTAGTCATGTACATTTTTTCCCGTATTACTTTACCTTTTTCAACCACTTGATTTAGCTGATCGTTTTGTTTAACAATGGCCGAAATAGCTTTCTTATTTTCTTTATCAGGATGTGTGGAATGCCAATAAAAATCTTTGTCTTGAACAATAACTACACTTGCTTGGTCTGCAAGTTCACGAGCAATCGATAGTCCTAGTTTTTCATCGTCCGTTTCCTGCACAATGGTAGAGATTTTAGCAGCCGTTTTAGTTAAACGGTTTTCTGCATCTACAACATGATAATTTTCAAAAAACTGAAGCAGTAAAATGGTCAAAATAAATAAAACAAGCGTGACGAGCAATAGGATAGTAAACCATAGTTTACCAACTACACTTCTCCAAAACATCAGTTATTTTCAACCTCAAATTTATACCCTACTCCCCAAACGGTTACAATCATTTTCGCCGCTTGTGACGATACACGATTTAACTTTTCACGCAAACGCTTGACGTGCGTATCTACCGTACGAAGATCTCCAAAGAAATCATAATGCCATACTTCACGCAGCAGCTGCTCTCTGTCATATACTTTATCTGGCGTTTTTGCGAGATAGCATAATAATTCATATTCTTTTGGAGTTAAGTTAACTTCTTTTCCGTCTGCTGTAACGCGATGTGCATCATTATCAATCGTTAAGTGATCAAAGACAATAAGATTTTTCACGCTCGTTTCTGGTTGAATAAACGTCGCTTGAGAAGAACGTCGAAGCAGTGCTTTTACGCGAAGAACCACTTCTCTTGGGCTAAACGGCTTAACGATATAATCATCTGTACCTACTTCAAACCCTTGGACTCTGTTTACTTCTTCCCCTTTAGCTGTAAGCATGATAATAGGAGTTGCTTTTTTCTCCCGAATTTGTTTACAAACCTCAATACCGTCTATGCCGGGCATCATTAAATCTAATACAATCAAATCATAATCTATGTGTAACGCTTTTTCGATTGCTTCATGCCCATCCGCTGCTTCTTCAATGATGTATCCTTCTTTTTCTAAGTACATTTTTAACAATCGTCTAATGCGATCTTCATCGTCTACTAGCAGTAATCTTTGTTCGTTTTGCAT

Protein sequences of DBSCAN-SWA_3

>NZ_CP018874|4170566:4179866|4176518_4177208_-|WP_013059049.1|DBSCAN-SWA
MIDVLRRILVVLVMGLCIGLLFLGGQMVKAEEKQWEWPVEGVLTDIFGSRHAKHFGIDIAAPVGTQVYAVAKGVVSRSYYSNTYGQVVFIKQTNGYETVYAHLEERFVAEGNRVAAGQNIGRVGNTGRSSGAHLHFEVHQESWNPDKTNAVNPLAKLDKQKLSAYVKSDLAATVFQQLHQTSDNCILIHQGDTLSELAVKYEVDIDQLRKWNHLENTMLNAGQVLKISP
>NZ_CP018874|4170566:4179866|4173741_4174317_-|WP_078082156.1|DBSCAN-SWA
MQQSKKTQKLVVLGMLSSIAYILMMINFPIPGLPPFLTIDFSEIPALVAALVFGPMAAVIVEGIKNLLNYLIQGSATGVPVGQVANFVAGLLFVLPVSYMFNRFKTAKGVTIGLVTGTVLMTVLMAVLNYYVFLPAYTIFLQSPEMSSEQARQYIVAGILPFNLIKGAATGVIFVLLFSKMKQWITRRIAV
>NZ_CP018874|4170566:4179866|4177377_4179150_-|WP_028410715.1|DBSCAN-SWA
MFWRSVVGKLWFTILLLVTLVLFILTILLLQFFENYHVVDAENRLTKTAAKISTIVQETDDEKLGLSIARELADQASVVIVQDKDFYWHSTHPDKENKKAISAIVKQNDQLNQVVEKGKVIREKMYMTTKKDTSDEPLMFVVGVPLMKDNKPTGGVYLYQSLSEIEEPAQYTTKFILLAAGIAIILTTIFAFFLSTRITAPLRKMRQAAFEVTKGNFDTKVPILTHDEIGELAIAFNQMGRQLKFNLNALNQEKEQLSSILSSMADGVITFSRDGSILITNPPAEHFLQTWYYEQDVNNQQVPELPANVVHLFQTVVETETERSAELKIQGKTWVILMSPLYNQTKIRGAVAVLRDMSEERKLDKSRKDFIANVSHELRTPISMLQGYSEAIIDDIASTDEEKKEIAQVIYDESLRMGRLVNELLDLARMEAGHVQLHLESVAMVEFTERVLRKFQGLAKEKHIKLSLNGKIEDEFEAMIDSDRMEQVLTNLIDNAIRHTDDYGEVKLHLDKSQSEIHLSVQDTGAGIPKEDLPFVFERFYKADKARTRGKSGTGLGLAIAKNIVEAHQGIIAVESELNEGTTFFIKLPK
>NZ_CP018874|4170566:4179866|4170566_4172084_-|WP_029320380.1|DBSCAN-SWA
MKIEQLLQKQFGYSQFRLGQKEIIQDILTGHNVLAVLPTGTGKSLCYQLPAYLLNRPVLIVSPLISLMEDQVQQLKASGEKRVIALNSFLQQEEKQRALKNLAFYRFIYASPEILQNAVVVEALKQAKVGLFVVDEAHCISQWGHDFRLDYLQLGDIWKELGSPLCLALTGTATREVVEDIKRYLSLPAVNEHIYSMNRSNIAMKVDFVASIEEKKEKLLMYVSELQGPGIIYCSSRSWTEALTQLLKENGIQRVQYYHGGMEPNERMLVQQQFLENQLDIICCTSAFGMGVNKSNVRFVIHFHTPTQLEAYVQEIGRSGRDQRNSIAILLYTEGDDDFAHSLLEIELPSSDTILYCLSYLRNHDQAIPLKQVESHFLYTVGVQETHWRFIRYYLYRENAVENEHVEPWKIPESLHETIVTAVNKRLRNKHDKYRAMKGFIETKECRRHVLLGYFDETGKSELENCCDCCGLDLENYKKTNGEQEQWTFQGWELELARLLRQGEI
>NZ_CP018874|4170566:4179866|4172107_4173157_-|WP_013059045.1|DBSCAN-SWA
MNYIQVSILFCIKQLKGERTAYGIYHLLTGKKSAQTIQDGKIFGISFLFQSFVYLDKRSFETCVAYLKEQQYIEETENQKYVMTDKGQARLEDELTARPFHPALDGWKFASSTQLFLARITLFIQTLSNLQYFQKGFLPISKNPEVIQWVKTYIMSQKQTRQELAAELFEELRTCLKGCTERDASLFVLQLTGYQRVGFTKNQLAYQYELDEHYVHIQLLGVIHHIIEKVSKNNESFHVLSSFLRDLYLELPLTSSTLKTYSWLQKGKTLEEIAYIRRLKESTIEDHIAELALFVPSFSIDAYVSPKQQEEIVSAFEGLRTNKLKVIKEEVKDDVTYFQIRLVLAKHFT
>NZ_CP018874|4170566:4179866|4179149_4179866_-|WP_013059051.1|DBSCAN-SWA
MQNEQRLLLVDDEDRIRRLLKMYLEKEGYIIEEAADGHEAIEKALHIDYDLIVLDLMMPGIDGIEVCKQIREKKATPIIMLTAKGEEVNRVQGFEVGTDDYIVKPFSPREVVLRVKALLRRSSQATFIQPETSVKNLIVFDHLTIDNDAHRVTADGKEVNLTPKEYELLCYLAKTPDKVYDREQLLREVWHYDFFGDLRTVDTHVKRLREKLNRVSSQAAKMIVTVWGVGYKFEVENN
>NZ_CP018874|4170566:4179866|4174912_4176487_+|WP_029320362.1|DBSCAN-SWA
MYNVLVADSISNEGLAPLLEAPHVNLTRKKVEEVENDLHTYDALLVRSATTVTEDLLTKMPNLKIVARAGVGVDNIDIEASTKRGVVVINAPNGNTISTAEHTFAMMASLFRHIPQGNASVKAREWNRSAFVGTELNRKHLGIIGFGRIGSELAKRAKAFNMSVHVYDPFLTSSRAEKLGVELLSLDELLAAADVITVHTPLTKETKGLLNHDTLAKTKKGVFLLNCARGGIIDEKALVHYLEIGHVQGAAIDVFEVEPPIDNPLLHFDQVITTPHLGASTKEAQLNVAEDVAHDVLRFLEGNPVSSSINLPTLSKEVFEKIQPFTSLTKQMGAILSQCMREPVQHISISYGGTVTDLETTYITRSLLSGFLTHRIDSPVNEVNASMIAKERGITFGEKTSEDTQGYSNMIDVTVTGEQRIFTITGTYIAGYGPRIINIDSFDIDFYPEGHLLYIRHSDQPGVIGNVGKVLGDLRINIATMQVGRKQKGGEAIMMLTFDKLLDDSVISSLKQTSEIVTIQRIEL
>NZ_CP018874|4170566:4179866|4173414_4173663_+|WP_013059046.1|DBSCAN-SWA
MPKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDDNQGVVEIPEDLEDDMMDAMEGCPTDSIRVADEKFEGDANKFE

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_029320380.1|4170566_4172084_-	ATP-dependent DNA helicase RecQ	F2NZ48	Diadromus_pulchellus_ascovirus	3.3e-53	35.6
WP_013059045.1|4172107_4173157_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013059046.1|4173414_4173663_+	ferredoxin	A0A127AYY7	Bacillus_phage	3.6e-18	54.1
WP_078082156.1|4173741_4174317_-	ECF transporter S component	NA	NA	NA	NA
WP_029320362.1|4174912_4176487_+	phosphoglycerate dehydrogenase	A0A2H4PQU8	Staphylococcus_phage	1.3e-28	29.8
WP_013059049.1|4176518_4177208_-	peptidoglycan DD-metalloendopeptidase family protein	Q8SBN9	Clostridium_phage	5.2e-14	42.1
WP_028410715.1|4177377_4179150_-	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	7.5e-25	26.3
WP_013059051.1|4179149_4179866_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.2e-47	42.2

2. NZ_CP018877

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018877_1

• CRISPR_ID: NZ_CP018877_1
• CRISPR_location: 53130-53243
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018877_1

Consensus_repeat	Method
TGAAGGTATTGGATCTTCTGTAGAAGGTGG	CRISPRCasFinder

spacers of NZ_CP018877_1

>1.1|53160|54|NZ_CP018877|CRISPRCasFinder
GAATGCTTCTCTACATGATGAAATGCAAGCTTCTGGTCAAAGTGAAAGCACAAG

CRISPR arrays and Neighbor proteins around NZ_CP018877_1

CRISPR arrays

The CRISPR arrays of NZ_CP018877_1

>merge|NZ_CP018877|1|53130-53243|CRISPRCasFinder
TGAAGGTATTGGATCTTCTGTAGAAGGTGGGAATGCTTCTCTACATGATGAAATGCAAGCTTCTGGTCAAAGTGAAAGCACAAGTGAAGGTACTGGATCTTCTGTAGAAGGTGG

>NZ_CP018877|1|1|53130-53243|CRISPRCasFinder
TGAAGGTATTGGATCTTCTGTAGAAGGTGG	GAATGCTTCTCTACATGATGAAATGCAAGCTTCTGGTCAAAGTGAAAGCACAAG
TGAAGGTACTGGATCTTCTGTAGAAGGTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018877.1|WP_078082408.1|51283_51490_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_047933325.1|46658_46964_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082404.1|46385_46637_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082400.1|44335_44770_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP018877.1|WP_078082413.1|55882_57817_+|type-IV-secretion-system-protein-VirB4	unknown	unknown	gnl|CDD|274279
NZ_CP018877.1|WP_047934013.1|62198_62678_+|hypothetical-protein	unknown	unknown	gnl|CDD|235883
NZ_CP018877.1|WP_078082406.1|48171_48681_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082415.1|58947_59529_+|MerR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP018877.1|WP_078082417.1|60974_62195_+|hypothetical-protein	unknown	unknown	gnl|CDD|375981
NZ_CP018877.1|WP_078082410.1|54045_54333_+|hypothetical-protein	unknown	unknown	gnl|CDD|375135
NZ_CP018877.1|WP_078082414.1|57820_58933_+|lysozyme-family-protein	unknown	unknown	gnl|CDD|381612
NZ_CP018877.1|WP_078082416.1|59539_60427_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082407.1|48670_51262_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	unknown	unknown	gnl|CDD|378923
NZ_CP018877.1|WP_078082403.1|45892_46357_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082411.1|54395_55052_+|uridine-kinase	unknown	unknown	gnl|CDD|180660
NZ_CP018877.1|WP_057240358.1|60698_60956_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082412.1|55151_55865_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082402.1|45161_45410_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_035439574.1|44909_45125_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
NZ_CP018877.1|WP_078082405.1|47031_48156_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018877.1|WP_078082414.1|57820_58933_+|lysozyme-family-protein	gnl|CDD|381612	cd16891, CwlT-like, CwlT-like N-terminal lysozyme domain and similar domains. CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	2.16303e-59
NZ_CP018877.1|WP_078082407.1|48670_51262_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	gnl|CDD|378923	pfam12696, TraG-D_C, TraM recognition site of TraD and TraG. This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.	1.28525e-32
NZ_CP018877.1|WP_078082400.1|44335_44770_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.31569e-12
NZ_CP018877.1|WP_078082413.1|55882_57817_+|type-IV-secretion-system-protein-VirB4	gnl|CDD|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	4.44438e-11
NZ_CP018877.1|WP_078082411.1|54395_55052_+|uridine-kinase	gnl|CDD|180660	PRK06696, PRK06696, uridine kinase; Validated.	2.02801e-107
NZ_CP018877.1|WP_047934013.1|62198_62678_+|hypothetical-protein	gnl|CDD|235883	PRK06901, PRK06901, oxidoreductase.	0.00795952
NZ_CP018877.1|WP_078082417.1|60974_62195_+|hypothetical-protein	gnl|CDD|375981	pfam18555, MobL, MobL relaxases. This family includes members of relaxase enzymes. These enzymes initiate bacterial conjugation contributing to the spread of antibiotic resistance. These MobL relaxases are found mainly in Firmicutes. It is suggested that MobL type relaxases play a prominent role in horizontal gene transfer in Firmicutes bacteria. Family members carry a stretch of relaxase motif III 'HUH' sequence that is characteristic of the HUH endonuclease superfamily essential for enzymatic activity.	3.21518e-114
NZ_CP018877.1|WP_035439574.1|44909_45125_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.60255e-14
NZ_CP018877.1|WP_078082410.1|54045_54333_+|hypothetical-protein	gnl|CDD|375135	pfam17332, pXO2-11, Uncharacterized protein pXO2-11. This is a protein of unknown function found in Firmicutes and predicted to contain 2 trans-membrane regions.	7.11602e-29

Protein sequences

>NZ_CP018877.1|WP_078082408.1|51283_51490_+|hypothetical-protein
MNSISKELERILEDYAPIVKEGHQVLIGLLDGTVQLEKGQEGEAPVQIRVSPLDERLEMTIDTLFQGM
>NZ_CP018877.1|WP_078082407.1|48670_51262_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein
MQPNKSIKYVVAEKQVLIPLSACFFVSILLILNFLFNMMRNLVQTTFSDVFEPQPFHLDTSFLTEIHLQQYSPLYGVMCLVAALLTAKFAYNIRSNFKDLNHNQKGSGRFTTRHELKKQYRKVPEKTTTYQGGGGVPVSRIQTYDLIQTWKEYKALKGIQKLLYTHRLFTKKSYMIIDDTPVNNLIIGITRSGKGETFVFPTIDIYSRAEKQPSLILNDPKGELLAASKKTLEERGYHVEVLNLLNPLESMSYNLLEMIKETYKDGDYSTAQALCNTLSYTLYYNPNAKDPFWQQCAMSLCNAMILAVTDKCIKEQTEEKITMYTVANMLSELGSKEIVINKQGDTQNALDMYFDGLPTESVAKMQYATSNFSKGTTRGGIFTQTMNGLSIFTFDEIAKMTSKNSVDLKRVGFGKTIKGTAAPLTRLEIIFPDGQTETIKTDAKGLFEVNFTSEVKQNDEIILAEKLSDKIVTSSRLETVISINKITKETGATTFTVEKQHPTIHVKEVTYFTKPIAIFMVTPDYDSSNHVIASIFVRQLYYVLSKNASLARGNKCHREVVLILDEFGNMPAIQDMANIITVCLGRNIRFNLVIQAYAQLKNKYGDNAETIEGNCGNTIYILTNNYETAKTISQKLGDGTINSTSRSGKGLSTDKSKTEGVDGKPLLTPNELMELKEGESVVVRVVKRQDKSRRRIKAHPIYNTRKTALKYRWEYLGDDFNTDRSILDIDIESLHKEVDPRKLIINNFFSFQQKQQKEESVEKEQESPDTPFSPMTYENWETKSVEEFFSEDPSVFEILKTELPGVMNKTIEEIQQQAMNDFVDEFKILSQNDQLDSNVYQLVETKIETTLAKLQGEVEKQEA
>NZ_CP018877.1|WP_078082406.1|48171_48681_+|hypothetical-protein
MYTQTKVKNQKQAFVVGVEYYEEDLFLEIELGSFYTTQLHAQRIANSVHNVILLENQIVIIFKNADSITLTDDFLKYAFKFRLCTKPTMPPLDISKLTQQEKDDLVCNEAYMVTEEDMEEVQWDINTAFRYLQYKYEARDQTFFSLSSSAYYVIPTSEEIDQEGMRNAT
>NZ_CP018877.1|WP_078082405.1|47031_48156_+|hypothetical-protein
MLSVMFIKSETKELKPFQKLSIPEACEITETVESQYQRARKKAHADFFILDEEDHEVYAGTLSIGSGLARHVVDHIKKKLGSLKMDDIQEARKRSFLEQLEKEVPDHLKTTDGSFSLEEETEDDVQTTQTPVLSTRNRRLIYGGGILSLLILSATCFSTVATSQDRAETIQDLQKQVKLEQKITGTYERALLGDSEGALKRLSSIDEQSLTNEQKNVYMSLLVDQKKYEEAVQLQGDHPEVVENMISKKGDVNALKEFQQTFPSPNGAFDLAYHEKRWEDMIRQSGVEMTDKRYEMKAYGYLKLDKVKEAKEEAAHIQNQKLNQKIGTYEKTKKEIEETKKQVEEENKKDKKDENKIKSLTDQQKKQEELLKNL
>NZ_CP018877.1|WP_047933325.1|46658_46964_+|hypothetical-protein
MLDLLNSVDVTQLTSHLTLGAADGMNGLIESGKSIIKWMQRIAMVAAALAFCVGGYHLILGGERGRHKCIAWFVGGAVGLVVVMGAYALAEGVNTNIRFGS
>NZ_CP018877.1|WP_078082404.1|46385_46637_+|hypothetical-protein
MTISQKELKKSKDLVEKLLKVNGNKYNDWLHQQHQQFIEENQDLILQALSAFTGQEEEEEEKSEPKVNEQVSVRPTSIPVTQN
>NZ_CP018877.1|WP_078082403.1|45892_46357_+|hypothetical-protein
MKNKKWLLSAVAGIVVALGIGTAFVSSYNSSEVKGNGELEELHPLEMKKFMKEDGTGFVMYSFEESKRDIYMNEVEKALKEQGVDGKELDSNDPQYDGSKNQTDYGLTQNAETLAAYKDGELKQQIKLDDYDPSQLETELSHFIETSKELYFEK
>NZ_CP018877.1|WP_078082402.1|45161_45410_+|hypothetical-protein
MEAQKRLAFYDISDARAKSAKTFDGKLYTLKGGVAVEKGTGDIKRVADIYYEVRSVMDQAHTIVAKRRKKDEELKEVLQRTC
>NZ_CP018877.1|WP_035439574.1|44909_45125_+|helix-turn-helix-transcriptional-regulator
MLEIKTIREKRLEKKWSQTYLAQLSGVPQPTISQIENGTRQYPTFENMKKIAEALDLRLEDIFLPGQKDMN
>NZ_CP018877.1|WP_078082400.1|44335_44770_-|helix-turn-helix-domain-containing-protein
MDQFNLELGNNIKSFRKSIFMSTTTLAELSNTSQGTISKIENGHSTSDIKTLIRICKALGVTLYDVLPDDISKEFKTDNPNKEQLFNILNDLSPSEIKVILSLLTTDIIPVLTNLSPVIKAFEQLGEKERKLFTDLLESMKSNS
>NZ_CP018877.1|WP_078082410.1|54045_54333_+|hypothetical-protein
MANYNIPKEISTELKINKSLYLFDLLFIIGLLMVTMMLRFFIHPTLQIPFYIFMGIFGLLMIIRPSTNPKKRMYEALLLTLVRKKSTYCAIDRDE
>NZ_CP018877.1|WP_078082411.1|54395_55052_+|uridine-kinase
MLRKKLISELANEVLSLKTRHPIRVGISGITSSGKTTLANELTEELQNRGKNVIRTSIDHFHNPRSIRYRQGKESALGYYQDAHDYESFKHKLLIPLGPEGNCQYQAASLDLATDQYVKPNIQLATKNMILIVDGTFLFKKQLCNLYDFKIFVSTDFELARKRGAKREEQAFGSYEKAEEMFIKRYHAASKIYLDEHQPQLSADVVINNNDLNDPYFI
>NZ_CP018877.1|WP_078082412.1|55151_55865_+|hypothetical-protein
MALFDERILEKEKPILKEKKTSKSLLFDEKELDKRIAQTKKKNLFSLLQLPKAEKEKRKEKLPEVKKSVADIIPIIDQTDSGLFQLKDDGGFFGIWQLQSTDINAMHDQEAGRNIYTLAKTYQGDKDPFKIISLNLPVSTQKQQQYLEKKIREANNALSLRFLRKKLKELQYLEWGRTNREYFLFLYGPTELAVKERKDQFMRDIQLAIPLLPVSDEKQINLLYKLYNQNAKLGNKQ
>NZ_CP018877.1|WP_078082413.1|55882_57817_+|type-IV-secretion-system-protein-VirB4
MITLPFRKKEKTPQEIKQKKGYNPYFVAQIQPQGGVSFKENLVRNGDGYSTCIHIYEYPTNVNDFWLEPIMNMPNAITTLDVVSDERKQVVEAINKNMSEQNARHVNAKENIDRMDAQEQYLDMKELYRQVTNGEVIKRIHLRIYIAEKTIPDLEKRLKEVIHHLETHNFRGSIFLNEQEYEWESLVTHFDIQKKYPNKRKGKEIPALALAGGFPFHFTHLDDPYGTYQGTTRTGGSVIFDLFHKDEKRKSYNAVLMGLMGSGKSTFLKKVTTDNAIKGYKVRGFDIVGEFESLVRELGGKQTALDGSEGQINPLQVFKTHKVERSSFTQHLSKLAVFYRFIAPEARDDELKEYEKLLRKLYIQKELWSDEKGVENQITGLPSEAYPIFSDFLKLIRKELYEDIETRRHHVHLGEYRKHRLELIELNIENIVENYGHLFDGISTIEDFNDEQVVFFSIRHLSKLKNEIAQAQLFNVMSLLWDEMLQNGQPQLEAYTKGELPFEDAIRYLIVIDEAHRIVNTKKGSEHALDFLTEFSREARKYFAGLIYASHLITDFVPEGSEQTAIEKIKTLFDLTQYKFIMNQDDNNLDTIQRVFKTGITDSELAEIPRLPVGDVLLCIKSVKNILFHIEIDEEEKVLYGGGA
>NZ_CP018877.1|WP_078082414.1|57820_58933_+|lysozyme-family-protein
MHIVLQLIPKKYLIGGTLILLGLSGLLIMSTIVAITGEFEKDSQQSEVTEIEGGGIGVGTANVSPEVMKYQPLLEKYAQKHGLDASYVPIMMALMMQESGGRGNDPMQSSESKCGRVGCIQNPEASIDQGVKHFKSVLEKSHYDLKLCLQSYNFGPGFINFIMKNGGKYTPELAIKFSQIQYQQVKHTGKYHCVRPEMVPYQACYGDSKYVDAVLKYYTGTITADGKPAAPASDGSGGKSGVKVIDAGKTLIGKTRYVFGGGRSQSDINAGRFDCSSFVRWAFEQVGVNVGPMSGVTTDTLKTQGQAINPKDMKPGDVVFFDTYKIDGHVGIYVGNNQFLGCQGKTGVAIASMANGTYFGERFNGRVKRF
>NZ_CP018877.1|WP_078082415.1|58947_59529_+|MerR-family-transcriptional-regulator
MENKAALLFGALAVVVAGVTIFNIYLNHNISNTTASKQIQVTNDSLQEENKELKKQLSEVRPSAQEQQKRDYLNTVNQFIDVSYHREKEGFEERKKVAKSIMDKELYEQFYPSEKFVYGDSYTSVPNDVQLYVQQYDGGQEEVEVIAEFTNHLVIKDEDVDDQTHDIIKVSLRKEENKWVVYSIEELKTEIMK
>NZ_CP018877.1|WP_078082416.1|59539_60427_+|hypothetical-protein
MAFKKKFEDYRFNLNRNRSWKYTAMLIFFFIGFLSLLTSKFYLKTEDPLYHTKTYEAVSSNITGTVTIENRVYHPATNSLDMIIKMDQTDEEEVSFVAQEKVNPNVKLPVQLLYEDDGYYVVRINDLSPNWEALAFDLYQENEEKETVNVDEVTTNYDTSSTEEIDAHALITSLYSDQRKTKSEEGKGTKSKQEYALLVNDLEKQFVKKKMKNYEKVIAVEAKHKRQTQQEMNELQRDMKYQVEEEKADTESKIAMKKDAIQSSDESIQLYEDEQKSLQEKLQKLNEKQQDLAMK
>NZ_CP018877.1|WP_057240358.1|60698_60956_+|hypothetical-protein
MEIKIRNVDPIAVKKIDELAKKHKLSRQEFLKGQLETLAFFREQVEREHELESLIEKNMIMMEKCATSMENMNHILLEMIGEVEE
>NZ_CP018877.1|WP_078082417.1|60974_62195_+|hypothetical-protein
MSKAINRTNIVPGVVVKTKFITSHHKAFQQYVEYVDRDEAKQEDRSVAHSFSLYQDYMGNPHKTSSLFTHKYDRLTEEQKAKLKESFEEAQNNNSIMWQDVITFHNPWLQEQGIYDARTHTVDERKLMYVTRQAMSKMLERERLNESAVWSAAIHYNTENLHIHIATVEPNPIRSRGKRKPKTLDVMKSTVVNQIRDRGKNQDRINHLIRKEMVDQKKQDSSFAWRNRELKPLFLMVYNHLPQDKRQWQYSYNTIKPLKPYIDTLSEKYIKKYHQKEYQQLIKNLDKEVKELKKAYGEGTRDKGRYENYKQTKIDDLYKRMGNAFLQEMKAYDRKQQDVKRLLDRKQSGNQTAKYKQHVPVHFSFRKIEKAFKSEYESWKNQQHYERLQRETERDRNQQNDYERGY
>NZ_CP018877.1|WP_047934013.1|62198_62678_+|hypothetical-protein
MEKQRMKLAIEDESKAYIESFKEEHGLRYTGDAIAQICKEHEASKSNEWSLKYITEVVSHHLHESLKNEFQALREEIHTLKGEMTKTKLGANAADKNTQILIEYMNGLFFHHGFKGLMTTSMQEMDSTRVARETVEKRIANQRQKRIDWEESRGKQQSH

Crispr_ID: NZ_CP018877_2

• CRISPR_ID: NZ_CP018877_2
• CRISPR_location: 60463-60530
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018877_2

Consensus_repeat	Method
ATTTGAGGGGGCGTTGAGGGGGTT	CRISPRCasFinder

spacers of NZ_CP018877_2

>2.1|60487|20|NZ_CP018877|CRISPRCasFinder
AGTGGCAAATTAGTTGAAAC

CRISPR arrays and Neighbor proteins around NZ_CP018877_2

CRISPR arrays

The CRISPR arrays of NZ_CP018877_2

>merge|NZ_CP018877|2|60463-60530|CRISPRCasFinder
ATTTGAGGGGGCGTTGAGGGGGTTAGTGGCAAATTAGTTGAAACATCTGAGGGGACGTTGAAGGGTCG

>NZ_CP018877|2|2|60463-60530|CRISPRCasFinder
ATTTGAGGGGGCGTTGAGGGGGTT	AGTGGCAAATTAGTTGAAAC
ATCTGAGGGGACGTTGAAGGGTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018877.1|WP_078082415.1|58947_59529_+|MerR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP018877.1|WP_078082408.1|51283_51490_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_047934013.1|62198_62678_+|hypothetical-protein	unknown	unknown	gnl|CDD|235883
NZ_CP018877.1|WP_078082418.1|62996_64349_+|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl|CDD|368753
NZ_CP018877.1|WP_078082417.1|60974_62195_+|hypothetical-protein	unknown	unknown	gnl|CDD|375981
NZ_CP018877.1|WP_078082422.1|69100_69706_-|hypothetical-protein	unknown	unknown	gnl|CDD|376069
NZ_CP018877.1|WP_078082407.1|48670_51262_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	unknown	unknown	gnl|CDD|378923
NZ_CP018877.1|WP_078082410.1|54045_54333_+|hypothetical-protein	unknown	unknown	gnl|CDD|375135
NZ_CP018877.1|WP_078082414.1|57820_58933_+|lysozyme-family-protein	unknown	unknown	gnl|CDD|381612
NZ_CP018877.1|WP_078082416.1|59539_60427_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082409.1|51513_54006_+|hypothetical-protein	unknown	unknown	gnl|CDD|377898
NZ_CP018877.1|WP_078082413.1|55882_57817_+|type-IV-secretion-system-protein-VirB4	unknown	unknown	gnl|CDD|274279
NZ_CP018877.1|WP_078082421.1|66499_67138_+|restriction-endonuclease	unknown	unknown	gnl|CDD|377369
NZ_CP018877.1|WP_078082419.1|64408_65440_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_053488179.1|62728_63004_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_078082411.1|54395_55052_+|uridine-kinase	unknown	unknown	gnl|CDD|180660
NZ_CP018877.1|WP_078082420.1|65517_66507_+|toprim-domain-containing-protein	unknown	unknown	gnl|CDD|379044
NZ_CP018877.1|WP_078082466.1|67155_68046_+|NADH-dehydrogenase	unknown	unknown	unknown
NZ_CP018877.1|WP_078082412.1|55151_55865_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018877.1|WP_057240358.1|60698_60956_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018877.1|WP_078082421.1|66499_67138_+|restriction-endonuclease	gnl|CDD|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	1.29814e-36
NZ_CP018877.1|WP_078082410.1|54045_54333_+|hypothetical-protein	gnl|CDD|375135	pfam17332, pXO2-11, Uncharacterized protein pXO2-11. This is a protein of unknown function found in Firmicutes and predicted to contain 2 trans-membrane regions.	7.11602e-29
NZ_CP018877.1|WP_078082418.1|62996_64349_+|ImmA/IrrE-family-metallo-endopeptidase	gnl|CDD|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	1.82693e-06
NZ_CP018877.1|WP_078082422.1|69100_69706_-|hypothetical-protein	gnl|CDD|376069	pfam18643, RE_BsaWI, BsaWI restriction endonuclease type 2. Type II restriction endonucleases recognize short 4-8 bp nucleotide sequences and cleave phosphodiester bonds within or close to their target site. BsaWI restriction endonuclease from the thermophilic bacterium Bacillus stearothermophilus W1718 belongs to a group of restriction endonucleases that share CCGG motif within their target sites, termed 'CCGG-family'. However, the R-(D/E)R motif residues, which are supposed to recognize CCGG from the major groove side, are poorly ordered and located far away from the DNA bases. BsaWI contacts with the CCGG tetranucleotide from the minor groove side. It is folded into two domains an N-terminal helical domain and a C-terminal catalytic domain. Furthermore, it carries a PDXKXE motif at the putative active site.	0.00585562
NZ_CP018877.1|WP_078082407.1|48670_51262_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	gnl|CDD|378923	pfam12696, TraG-D_C, TraM recognition site of TraD and TraG. This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation. These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore.	1.28525e-32
NZ_CP018877.1|WP_078082417.1|60974_62195_+|hypothetical-protein	gnl|CDD|375981	pfam18555, MobL, MobL relaxases. This family includes members of relaxase enzymes. These enzymes initiate bacterial conjugation contributing to the spread of antibiotic resistance. These MobL relaxases are found mainly in Firmicutes. It is suggested that MobL type relaxases play a prominent role in horizontal gene transfer in Firmicutes bacteria. Family members carry a stretch of relaxase motif III 'HUH' sequence that is characteristic of the HUH endonuclease superfamily essential for enzymatic activity.	3.21518e-114
NZ_CP018877.1|WP_078082414.1|57820_58933_+|lysozyme-family-protein	gnl|CDD|381612	cd16891, CwlT-like, CwlT-like N-terminal lysozyme domain and similar domains. CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	2.16303e-59
NZ_CP018877.1|WP_078082409.1|51513_54006_+|hypothetical-protein	gnl|CDD|377898	pfam07695, 7TMR-DISM_7TM, 7TM diverse intracellular signalling. This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).	0.00012315
NZ_CP018877.1|WP_078082413.1|55882_57817_+|type-IV-secretion-system-protein-VirB4	gnl|CDD|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	4.44438e-11
NZ_CP018877.1|WP_078082411.1|54395_55052_+|uridine-kinase	gnl|CDD|180660	PRK06696, PRK06696, uridine kinase; Validated.	2.02801e-107
NZ_CP018877.1|WP_078082420.1|65517_66507_+|toprim-domain-containing-protein	gnl|CDD|379044	pfam13155, Toprim_2, Toprim-like. This is a family or Toprim-like proteins.	6.74405e-12
NZ_CP018877.1|WP_047934013.1|62198_62678_+|hypothetical-protein	gnl|CDD|235883	PRK06901, PRK06901, oxidoreductase.	0.00795952

Protein sequences

>NZ_CP018877.1|WP_078082416.1|59539_60427_+|hypothetical-protein
MAFKKKFEDYRFNLNRNRSWKYTAMLIFFFIGFLSLLTSKFYLKTEDPLYHTKTYEAVSSNITGTVTIENRVYHPATNSLDMIIKMDQTDEEEVSFVAQEKVNPNVKLPVQLLYEDDGYYVVRINDLSPNWEALAFDLYQENEEKETVNVDEVTTNYDTSSTEEIDAHALITSLYSDQRKTKSEEGKGTKSKQEYALLVNDLEKQFVKKKMKNYEKVIAVEAKHKRQTQQEMNELQRDMKYQVEEEKADTESKIAMKKDAIQSSDESIQLYEDEQKSLQEKLQKLNEKQQDLAMK
>NZ_CP018877.1|WP_078082415.1|58947_59529_+|MerR-family-transcriptional-regulator
MENKAALLFGALAVVVAGVTIFNIYLNHNISNTTASKQIQVTNDSLQEENKELKKQLSEVRPSAQEQQKRDYLNTVNQFIDVSYHREKEGFEERKKVAKSIMDKELYEQFYPSEKFVYGDSYTSVPNDVQLYVQQYDGGQEEVEVIAEFTNHLVIKDEDVDDQTHDIIKVSLRKEENKWVVYSIEELKTEIMK
>NZ_CP018877.1|WP_078082414.1|57820_58933_+|lysozyme-family-protein
MHIVLQLIPKKYLIGGTLILLGLSGLLIMSTIVAITGEFEKDSQQSEVTEIEGGGIGVGTANVSPEVMKYQPLLEKYAQKHGLDASYVPIMMALMMQESGGRGNDPMQSSESKCGRVGCIQNPEASIDQGVKHFKSVLEKSHYDLKLCLQSYNFGPGFINFIMKNGGKYTPELAIKFSQIQYQQVKHTGKYHCVRPEMVPYQACYGDSKYVDAVLKYYTGTITADGKPAAPASDGSGGKSGVKVIDAGKTLIGKTRYVFGGGRSQSDINAGRFDCSSFVRWAFEQVGVNVGPMSGVTTDTLKTQGQAINPKDMKPGDVVFFDTYKIDGHVGIYVGNNQFLGCQGKTGVAIASMANGTYFGERFNGRVKRF
>NZ_CP018877.1|WP_078082413.1|55882_57817_+|type-IV-secretion-system-protein-VirB4
MITLPFRKKEKTPQEIKQKKGYNPYFVAQIQPQGGVSFKENLVRNGDGYSTCIHIYEYPTNVNDFWLEPIMNMPNAITTLDVVSDERKQVVEAINKNMSEQNARHVNAKENIDRMDAQEQYLDMKELYRQVTNGEVIKRIHLRIYIAEKTIPDLEKRLKEVIHHLETHNFRGSIFLNEQEYEWESLVTHFDIQKKYPNKRKGKEIPALALAGGFPFHFTHLDDPYGTYQGTTRTGGSVIFDLFHKDEKRKSYNAVLMGLMGSGKSTFLKKVTTDNAIKGYKVRGFDIVGEFESLVRELGGKQTALDGSEGQINPLQVFKTHKVERSSFTQHLSKLAVFYRFIAPEARDDELKEYEKLLRKLYIQKELWSDEKGVENQITGLPSEAYPIFSDFLKLIRKELYEDIETRRHHVHLGEYRKHRLELIELNIENIVENYGHLFDGISTIEDFNDEQVVFFSIRHLSKLKNEIAQAQLFNVMSLLWDEMLQNGQPQLEAYTKGELPFEDAIRYLIVIDEAHRIVNTKKGSEHALDFLTEFSREARKYFAGLIYASHLITDFVPEGSEQTAIEKIKTLFDLTQYKFIMNQDDNNLDTIQRVFKTGITDSELAEIPRLPVGDVLLCIKSVKNILFHIEIDEEEKVLYGGGA
>NZ_CP018877.1|WP_078082412.1|55151_55865_+|hypothetical-protein
MALFDERILEKEKPILKEKKTSKSLLFDEKELDKRIAQTKKKNLFSLLQLPKAEKEKRKEKLPEVKKSVADIIPIIDQTDSGLFQLKDDGGFFGIWQLQSTDINAMHDQEAGRNIYTLAKTYQGDKDPFKIISLNLPVSTQKQQQYLEKKIREANNALSLRFLRKKLKELQYLEWGRTNREYFLFLYGPTELAVKERKDQFMRDIQLAIPLLPVSDEKQINLLYKLYNQNAKLGNKQ
>NZ_CP018877.1|WP_078082411.1|54395_55052_+|uridine-kinase
MLRKKLISELANEVLSLKTRHPIRVGISGITSSGKTTLANELTEELQNRGKNVIRTSIDHFHNPRSIRYRQGKESALGYYQDAHDYESFKHKLLIPLGPEGNCQYQAASLDLATDQYVKPNIQLATKNMILIVDGTFLFKKQLCNLYDFKIFVSTDFELARKRGAKREEQAFGSYEKAEEMFIKRYHAASKIYLDEHQPQLSADVVINNNDLNDPYFI
>NZ_CP018877.1|WP_078082410.1|54045_54333_+|hypothetical-protein
MANYNIPKEISTELKINKSLYLFDLLFIIGLLMVTMMLRFFIHPTLQIPFYIFMGIFGLLMIIRPSTNPKKRMYEALLLTLVRKKSTYCAIDRDE
>NZ_CP018877.1|WP_078082409.1|51513_54006_+|hypothetical-protein
MKDEEILKKLHEFSDYLDVGDIPSYLLRKIGWACIQLLSFLVDGLEGITDSILGVKAFFNSPEIQDFITKIQPFLYVLLAFSFLYIGYMLIIQKKVNREQIMINIFISMAVLLLLNTSMLKADKFTDQAIEAVDLNEKGTVSEKIIKSNITDVAQFDLTKWKSPKLKESNKVPQKNIMMIDITEKMDEDFKVNEKDKLSDDGQKIITHKADITPDGKEGLVELDNGWFDFFPELYYRWSWNFWTIAISLFVIGMTLLFTSIKLAKLCYELGFNAILAQLVAPADVADGQKLKAVLKNILNTFLVTIMIFISMKVYLMGTVFISDKLEGIPYLIALIAFSIAVVDGPVMCERLFGIDAGLKSGWGALAGGFAMAKGLESGIGMMGRTLKGGANLAKGVGNVGKGLGSGALQTAAGVGGFGKGLATQGNKEKQPALHEEMKKAGMAGEKGNAASKGQNAGNEQKAQQQGLSSTEKQEGGKNTEGNSSEGKGAGQGQGSSLQDEMQAAGVSTDSQGSTSSVEGGNTSLHDEMQASGYGESANEGIGSSVEGGNASLHDEMQASGQSESTSEGTGSSVEGGSASLHDEMQASGHSGSTNGGSSSVGKVSTSLHDEMQASGHSGNTNGGSSSVGKASTPLHGEMQASGHSGSTNGGSSSVGKASTPLHGEMQASGHSGSTNGGSSSVRSVSTPVHEEIQTSGYGGSTSEGGSSVESVSYPTPTREPSVSIPTGMDQAQAQVAATQEPRQGKQQIEKDTVPASTDDIPMPDQNRIETRNIAQVVKDNFKGGVGKVKERIDNSQTIHKTKRSYQIGRNTGRDLRNLGSKKRNKPEEK
>NZ_CP018877.1|WP_078082408.1|51283_51490_+|hypothetical-protein
MNSISKELERILEDYAPIVKEGHQVLIGLLDGTVQLEKGQEGEAPVQIRVSPLDERLEMTIDTLFQGM
>NZ_CP018877.1|WP_078082407.1|48670_51262_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein
MQPNKSIKYVVAEKQVLIPLSACFFVSILLILNFLFNMMRNLVQTTFSDVFEPQPFHLDTSFLTEIHLQQYSPLYGVMCLVAALLTAKFAYNIRSNFKDLNHNQKGSGRFTTRHELKKQYRKVPEKTTTYQGGGGVPVSRIQTYDLIQTWKEYKALKGIQKLLYTHRLFTKKSYMIIDDTPVNNLIIGITRSGKGETFVFPTIDIYSRAEKQPSLILNDPKGELLAASKKTLEERGYHVEVLNLLNPLESMSYNLLEMIKETYKDGDYSTAQALCNTLSYTLYYNPNAKDPFWQQCAMSLCNAMILAVTDKCIKEQTEEKITMYTVANMLSELGSKEIVINKQGDTQNALDMYFDGLPTESVAKMQYATSNFSKGTTRGGIFTQTMNGLSIFTFDEIAKMTSKNSVDLKRVGFGKTIKGTAAPLTRLEIIFPDGQTETIKTDAKGLFEVNFTSEVKQNDEIILAEKLSDKIVTSSRLETVISINKITKETGATTFTVEKQHPTIHVKEVTYFTKPIAIFMVTPDYDSSNHVIASIFVRQLYYVLSKNASLARGNKCHREVVLILDEFGNMPAIQDMANIITVCLGRNIRFNLVIQAYAQLKNKYGDNAETIEGNCGNTIYILTNNYETAKTISQKLGDGTINSTSRSGKGLSTDKSKTEGVDGKPLLTPNELMELKEGESVVVRVVKRQDKSRRRIKAHPIYNTRKTALKYRWEYLGDDFNTDRSILDIDIESLHKEVDPRKLIINNFFSFQQKQQKEESVEKEQESPDTPFSPMTYENWETKSVEEFFSEDPSVFEILKTELPGVMNKTIEEIQQQAMNDFVDEFKILSQNDQLDSNVYQLVETKIETTLAKLQGEVEKQEA
>NZ_CP018877.1|WP_057240358.1|60698_60956_+|hypothetical-protein
MEIKIRNVDPIAVKKIDELAKKHKLSRQEFLKGQLETLAFFREQVEREHELESLIEKNMIMMEKCATSMENMNHILLEMIGEVEE
>NZ_CP018877.1|WP_078082417.1|60974_62195_+|hypothetical-protein
MSKAINRTNIVPGVVVKTKFITSHHKAFQQYVEYVDRDEAKQEDRSVAHSFSLYQDYMGNPHKTSSLFTHKYDRLTEEQKAKLKESFEEAQNNNSIMWQDVITFHNPWLQEQGIYDARTHTVDERKLMYVTRQAMSKMLERERLNESAVWSAAIHYNTENLHIHIATVEPNPIRSRGKRKPKTLDVMKSTVVNQIRDRGKNQDRINHLIRKEMVDQKKQDSSFAWRNRELKPLFLMVYNHLPQDKRQWQYSYNTIKPLKPYIDTLSEKYIKKYHQKEYQQLIKNLDKEVKELKKAYGEGTRDKGRYENYKQTKIDDLYKRMGNAFLQEMKAYDRKQQDVKRLLDRKQSGNQTAKYKQHVPVHFSFRKIEKAFKSEYESWKNQQHYERLQRETERDRNQQNDYERGY
>NZ_CP018877.1|WP_047934013.1|62198_62678_+|hypothetical-protein
MEKQRMKLAIEDESKAYIESFKEEHGLRYTGDAIAQICKEHEASKSNEWSLKYITEVVSHHLHESLKNEFQALREEIHTLKGEMTKTKLGANAADKNTQILIEYMNGLFFHHGFKGLMTTSMQEMDSTRVARETVEKRIANQRQKRIDWEESRGKQQSH
>NZ_CP018877.1|WP_053488179.1|62728_63004_+|hypothetical-protein
MFFNKDLVLASIKAVGEDHAIVQYQDKEVEVNLSPEEAKEFHQYVVHQENMLVPMNIKTQKLFVDLEEPWYEQELEELKGISYQEEEEEDE
>NZ_CP018877.1|WP_078082418.1|62996_64349_+|ImmA/IrrE-family-metallo-endopeptidase
MSKAYAKKSVEDKRKEVEELTKGMEKKVEQHFHSAEELKDYLSFMGKFYQCSMSNTALIQEQFFGAQAVGSFKFWKDKGFSVNKGEKGIKIFVPNKTVPKFKDENGKLKSINKATPQEKKLIQEGKKEVTQGRLYFSVGHVFEISQTNAKASDLPKIFPNRWLEGNVEDYKALYKGMEAIGEKNGISIIQPKEELGAAKGVSYTLTKEVALNPRNSKRQNVKTLIHELAHAKLHTKDTHLNYTAAEKEFQAEMTAYTVSSYFGIDTSEYSLDYLSHWTKGKSFEDKTKLLKEVHETSVGFIETIEETLVKEREKNQSPEKNDEKQQQADPLSSENVQEKMKEGYEDYKQKQQQESAQNVDSILDRVTAEEKYYSTKTQAIKNGWMTKEEVVKLEHQIDSTITKNEKGIINGQVQEQSLTFQDRMEVGSHMQFQKRTGTVKKKKEEQEIER
>NZ_CP018877.1|WP_078082419.1|64408_65440_+|hypothetical-protein
MKKITSLSNEQFKTFVSDKRELKKFMKHPQNEKIEADWANISEKQLQGIPSGAVYLTQSALGEEKPQVLLVSTDEKGQKQAYKSEATVDFLRSHDVNPVLEKDRETQLKTSYLTFLQAHEKEKPQDIDSMLARVNAENDYVMLKSSALKEKQFTPDQLKGMENELSHQFQARKQAQEKEQYQEDYKQEVLEVMQQPSEETQYKQLFKQSLLAQLGISDEKDSSKGVKKEAESEKAPVEKQLKQETPQEKEQRLAKMKEFEQKHSFDKVYKLKKEVLQELKELNLTDSQREKLTKLEKALDTEKKDHDKQKKEEKSQNGFTKFFARNNGAFSSEKRQEQQEIER
>NZ_CP018877.1|WP_078082420.1|65517_66507_+|toprim-domain-containing-protein
MGERKYVNEGEIMKARDVDLLSYLKAKGETFVKEGKYYRHTEHDSLLIKGNMYAWNSRNEKGYGAISFAQMYYGMSFPQAVLDINKGDYKEMAHSQEQPSVSPSKEPFRYPKELEVKDQSKIKDYLIKERKIDSRLVDWLLQKDLIAQDKRNNVVFKWREHGGKGKVIGADRQGTTSISNKRGSFKQVLPNNNPHTGFSVDVGRPNKIHFFESPIDLLSYWSIQENQLQNTRLISMNGLKPKTVAQSYIEARKEGLGIKEMVLAVDNDQGGKEFINKMNQIVNADLIRADIPKGAKDWNEKLKKNGKSIQPVASRLRNKQTEQELSMNG
>NZ_CP018877.1|WP_078082421.1|66499_67138_+|restriction-endonuclease
MDKVFQGVFYLFLIMILVKLSQFAYRVLRERRYMKDLTQSGMPYIDQMDGYQFEIYLQALFQQLGYKPQVTKKSGDFGADLVMKGKENIVIQAKRYGIKNRVSISAVQEVYGAKAYYKANQAWVVTNSYFTKQAKELAAACDVTLVDRADLQKFINEIKPVFKAREIFENITPEPRKCPKCGQDLVVRDGNGTRFFGCSSFPSCRHTEKINK
>NZ_CP018877.1|WP_078082466.1|67155_68046_+|NADH-dehydrogenase
MKDILYQTLIEKGVPDSHISDMRETLNISEYPYRMYYDEIFDDRETYRHVPLSKVKSLGYRGTNGLSWFDHACYNGTDNIDIGRCHRAYEYLEKQSLEEFHAYYKHSAVKLIHFKDDDFYAVYGDGTHRTLWAKVTGAPTLYAVVTQAKKNHERYHAYRWFKVLEKDFNIYLKKHELDWGKDCSDSLSNIVYRGKSIGYFSIYSPREFNWKYDFSNEKLNDWKVQQQQFKEDISKSLQSKKDFQTIMRLTPQKLKSKVHSFFDYRRHHWMFSNEGKFKFKQIGFDMFCIDQKNTSS
>NZ_CP018877.1|WP_078082422.1|69100_69706_-|hypothetical-protein
MANKVSNNDIVKELFDRHPIDQDLAASQLVDFYYKKYLEIYGSNNSRNGTILEEILVIALLREGISPIYTQATMAFVPNVIFDILLYNRKTPICISSKVSLRERWKQADVEAMALKYVHRKAKAYVLTLSENEVRARRSDENSYMGIDEFVLAHTEEFDYLIENLRQIEITESETIEVITEAERKIVNFDTIKAKYGIELN

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018877_1	1.1|53160|54|NZ_CP018877|CRISPRCasFinder	53160-53213	54	NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	53160-53213	0	1.0
NZ_CP018877_2	2.1|60487|20|NZ_CP018877|CRISPRCasFinder	60487-60506	20	NZ_CP045276	Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence	99837-99856	0	1.0
NZ_CP018877_2	2.1|60487|20|NZ_CP018877|CRISPRCasFinder	60487-60506	20	NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	60487-60506	0	1.0

1. spacer 1.1|53160|54|NZ_CP018877|CRISPRCasFinder matches to NZ_CP018877 (Bacillus megaterium strain JX285 plasmid 4, complete sequence) position: , mismatch: 0, identity: 1.0

gaatgcttctctacatgatgaaatgcaagcttctggtcaaagtgaaagcacaag	CRISPR spacer
gaatgcttctctacatgatgaaatgcaagcttctggtcaaagtgaaagcacaag	Protospacer
******************************************************

2. spacer 2.1|60487|20|NZ_CP018877|CRISPRCasFinder matches to NZ_CP045276 (Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence) position: , mismatch: 0, identity: 1.0

agtggcaaattagttgaaac	CRISPR spacer
agtggcaaattagttgaaac	Protospacer
********************

3. spacer 2.1|60487|20|NZ_CP018877|CRISPRCasFinder matches to NZ_CP018877 (Bacillus megaterium strain JX285 plasmid 4, complete sequence) position: , mismatch: 0, identity: 1.0

agtggcaaattagttgaaac	CRISPR spacer
agtggcaaattagttgaaac	Protospacer
********************