CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019229	Tessaracoccus sp. T2.5-30, complete genome	9 crisprs	DinG,csa3,WYL,DEDDh,cas3	2	4	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019229_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_1

1192229-1192320

Orphan

Consensus_repeat	Method
CGGGAGATAGGACAGGCGCCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019229_1

>merge|NZ_CP019229|1|1192229-1192320|CRISPRCasFinder
CGGGAGATAGGACAGGCGCCGCGCTCGCACCTGCCTCGCGTTCATGCGCCTGCGCTCTAGAGCAGGCGCCGGGAGATAGGGCAGGCGCCGCG

>NZ_CP019229|1|1|1192229-1192320|CRISPRCasFinder
CGGGAGATAGGACAGGCGCCGCG	CTCGCACCTGCCTCGCGTTCATGCGCCTGCGCTCTAGAGCAGGCGC
CGGGAGATAGGGCAGGCGCCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068751581.1\|1185593_1187111_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP019229.1\|WP_078919773.1\|1198898_1199627_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP019229.1\|WP_068751591.1\|1198359_1198902_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP019229.1\|WP_068751587.1\|1190747_1191395_-\|TrmH-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349969
NZ_CP019229.1\|WP_068751579.1\|1183471_1184530_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380660
NZ_CP019229.1\|WP_068751582.1\|1187268_1187607_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP019229.1\|WP_068751593.1\|1199657_1200713_-\|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|376752
NZ_CP019229.1\|WP_068751595.1\|1201470_1203936_-\|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl\|CDD\|234896
NZ_CP019229.1\|WP_068751583.1\|1187677_1188706_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NZ_CP019229.1\|WP_141680069.1\|1192386_1193154_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NZ_CP019229.1\|WP_078920423.1\|1184592_1185477_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119321
NZ_CP019229.1\|WP_078919772.1\|1193226_1194735_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP019229.1\|WP_141680068.1\|1190347_1190758_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380097
NZ_CP019229.1\|WP_068751755.1\|1196174_1198367_+\|malate-synthase-G	unknown	unknown	gnl\|CDD\|235097
NZ_CP019229.1\|WP_068751585.1\|1189373_1190246_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP019229.1\|WP_068751588.1\|1191488_1192031_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NZ_CP019229.1\|WP_068751756.1\|1203929_1204517_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|235662
NZ_CP019229.1\|WP_068751584.1\|1188808_1189348_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_068751594.1\|1200745_1201465_+\|cobalt-precorrin-6A-reductase	unknown	unknown	gnl\|CDD\|236144
NZ_CP019229.1\|WP_068751590.1\|1194838_1196113_+\|isocitrate-lyase	unknown	unknown	gnl\|CDD\|237893

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068751581.1\|1185593_1187111_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP019229.1\|WP_078919773.1\|1198898_1199627_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	3.98803e-41
NZ_CP019229.1\|WP_068751591.1\|1198359_1198902_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	6.84077e-64
NZ_CP019229.1\|WP_068751587.1\|1190747_1191395_-\|TrmH-family-RNA-methyltransferase	gnl\|CDD\|349969	cd18096, SpoU-like, SAM-dependent rRNA or tRNA methylase related to SpoU. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	6.05828e-62
NZ_CP019229.1\|WP_068751579.1\|1183471_1184530_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380660	cd20005, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein such as CUT2. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	1.73406e-114
NZ_CP019229.1\|WP_068751583.1\|1187677_1188706_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP019229.1\|WP_068751593.1\|1199657_1200713_-\|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	gnl\|CDD\|376752	pfam02277, DBI_PRT, Phosphoribosyltransferase. This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.	5.63848e-151
NZ_CP019229.1\|WP_068751595.1\|1201470_1203936_-\|cobyrinate-a,c-diamide-synthase	gnl\|CDD\|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NZ_CP019229.1\|WP_068751582.1\|1187268_1187607_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	4.291e-26
NZ_CP019229.1\|WP_141680069.1\|1192386_1193154_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	4.2301e-71
NZ_CP019229.1\|WP_078920423.1\|1184592_1185477_-\|ABC-transporter-permease	gnl\|CDD\|119321	cd06579, TM_PBP1_transp_AraH_like, Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.	3.88894e-69
NZ_CP019229.1\|WP_078919772.1\|1193226_1194735_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	7.02927e-14
NZ_CP019229.1\|WP_141680068.1\|1190347_1190758_+\|hypothetical-protein	gnl\|CDD\|380097	pfam18050, Cyclophil_like2, Cyclophilin-like family. This entry represents a family of cyclophilin-like proteins found in a range of bacterial species.	3.15618e-10
NZ_CP019229.1\|WP_068751755.1\|1196174_1198367_+\|malate-synthase-G	gnl\|CDD\|235097	PRK02999, PRK02999, malate synthase G; Provisional.	0
NZ_CP019229.1\|WP_068751585.1\|1189373_1190246_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	9.08412e-49
NZ_CP019229.1\|WP_068751588.1\|1191488_1192031_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	2.12836e-56
NZ_CP019229.1\|WP_068751756.1\|1203929_1204517_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|235662	PRK05986, PRK05986, cob(I)yrinic acid a,c-diamide adenosyltransferase.	5.05316e-91
NZ_CP019229.1\|WP_068751594.1\|1200745_1201465_+\|cobalt-precorrin-6A-reductase	gnl\|CDD\|236144	PRK08057, PRK08057, cobalt-precorrin-6x reductase; Reviewed.	4.90795e-87
NZ_CP019229.1\|WP_068751590.1\|1194838_1196113_+\|isocitrate-lyase	gnl\|CDD\|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0

>NZ_CP019229.1|WP_068751588.1|1191488_1192031_-|YceI-family-protein
MNLNELNGTYVIDPTHSTLSFVTRHAMVTKVRGSFEKFEGQAIVDAANPAATQLTVTIDAASINTRNADRDAHVRSADFFHVEEYPTWTFVGTGYAVKGDVVEVTGDLTIAGTTRSITIPLEYQGAAKDPFGNTRVGFEGSTQVNRSDFGLTWNAALETGGFLVSDKVTIEVEISAIQQA
>NZ_CP019229.1|WP_068751587.1|1190747_1191395_-|TrmH-family-RNA-methyltransferase
MTETVDDPTAPTVGVGPHPEPWPDDDRLDPALLAEGDRRNVVDRYRYWRMEAIVADLDRTRVPLHVAIQNWEHDFNIGSIVRTANAFNVAAVHIVGRRRWNRRGAMVTDRYLHVLHHDDEAALLAHLAGEGLTPIGVDNLPGSVPLETARLPERCCLVFGSEGPGLTDAMVAGCERLVAITQRGSTRSMNAGAAAAIAMYHWSLQHSAPTPPLSR
>NZ_CP019229.1|WP_141680068.1|1190347_1190758_+|hypothetical-protein
MSRITMSLLAMAVTLVTTSCAAFPEVSAVPQSTVRIHAGSDVVLPGTLRFADRMGTAHVAPLPAPLSLDEARRLTAPEAGDVGYAPEAQALVVFLHDRRGTGGEELLAVGRVTSGLDDLAGCVQDCLVALVPTVND
>NZ_CP019229.1|WP_068751585.1|1189373_1190246_-|helix-turn-helix-domain-containing-protein
MDNRSEVREFLMSRRARVEPEMVGLPRMGGRRVPGLRRSEAATLAGVSVEYYSRLERGAIAGASTAVLDALARALLMDDAEREHLHRLARQAGDGAPRRRGRPLDRWRPSPSIQWVLDSMASAVAMIGNGRTDLLAWNALGGALMDEMIANAGSRPPNFARYLFLDPGSQTFYPDWEKAAAVNVAMLRTEAGRDPHASALQDLVGELSTRSETFRRLWGQHDVWQHESGTKRYRHHAVGDMELHFDGLDLVGQPGAQMTVLTAAPGSRDADTLRLLGPWASTRDVSVPQR
>NZ_CP019229.1|WP_068751584.1|1188808_1189348_-|hypothetical-protein
MQPERFAVGLTPLPTAARVAQKRGALRWRIISTVISLAILAVLVLTIGRDWSREWTIAMVVLWVGSSAFWLVLSVVGLQRAKRDLARIHDGVAFYLDPHGIEFVEPPHPRVRWDDVSALRLVGGGFGAGPAVALEVDGARVAGVPLSFLDASASVIDSAVRAYSLGRVHLDVTALDRVL
>NZ_CP019229.1|WP_068751583.1|1187677_1188706_-|class-II-fructose-bisphosphate-aldolase
MPIATPEVYAEMLDRAKAGKFAYPAINITSSQTVTAAIQGFAEAGSDGIIQVSTGGAEYASGSTIKDKVTGAVALAAYAQEVAKNYSVQIALHTDHCPKDKLDSFVRPLLAISAERVKRGELPLFQSHMWDGSAVPMEENLQIADELLALTKAANIILEIEVGVVGGEEDGVSAEINDKLYTTIEDGMRTAEVLGLGEKGRYMTALTFGNVHGVYKPGAVKLRPEVLKEIQDAVGAKYGKDKPFDLVFHGGSGSTPQEISDAVDFGVIKMNIDTDTQYAFTRPVVEHMFRNYDGVLKVDGEVGNKKAYDPRAWGKLAEAGMAARIVEACQNLRSAGTTMGAK
>NZ_CP019229.1|WP_068751582.1|1187268_1187607_+|rhodanese-like-domain-containing-protein
MTLLALVMSVAALLGLAGCSSSETDAALTAIESGATVIDVRTPAEYDSGHVDGALNIDVQAPDFAEKVGELPKDETYVVYCRSGNRSAAAIDIMEDLGFTDLIDGGAYSSLS
>NZ_CP019229.1|WP_068751581.1|1185593_1187111_-|sugar-ABC-transporter-ATP-binding-protein
MTTLLELKNVSKTFPGVKALSNVHLDLNAGEVLGLCGENGAGKSTLMKILTGIYTPDPGAEIWLQGKKVEVRNTNHARDLGLSIIHQELNMVPDLTVAQNLFLGRPGSHRAGFVDDAKLNAQAADLFDRLGMRLNPKAYVRDLSVARQQMVEIARALSYDSRILVMDEPTAALTLAETDALFGMIRDFVTPETGLIYISHRMPEIEEITDRVSVLRDGQYIGTVVTKEVEMREIISMMVGREVSGDARPRTMPESDEVVLKVQGLNTKKLLRDVSFEVRKGEVLGFAGLMGAGRTEVARAVFGADPRTGGEIFLHGKKVPIRNAADAVRSGIGYLSEDRKQFGVLLDQDVKANTAMAAMKDFHIGGFILDGKIKTVGTEYSQKLRVKTPSVNQLLGKLSGGNQQKVVIAKWLVRNCDVLIFDEPTRGIDVGAKEEIYNLIEQLSTQGKAIIVISSELPEVLRVSHRIAVMAHGHITGFLDNADATQENIMELATVGKAQLKGNAA
>NZ_CP019229.1|WP_078920423.1|1184592_1185477_-|ABC-transporter-permease
MIFAPNFSAGVVIPNILLQAAAIGTMALGATFVIGTGGIDLSVGTGMTFSAVMAGVFMSAEFMNLPLGLGLLLVLIVGAVMGLVNGLLIAYLHIPPFIATLAMMMVTRGLSLIISNASSIKIANPDYSAISNGRIIPFLSNAALIFVILGIIAAVILGKTLLGRYALAIGSNEEATRLSGINVKFWKALVYVTAGIFTAFGAILYSGRFGFVQPAEGLGMELQVIAAVVIGGTSLSGGRANIVGTMMGALLMMTLTVGLQMMGVAQQWQLVVTGIVVLLAVYADILRRQRASAV
>NZ_CP019229.1|WP_068751579.1|1183471_1184530_-|ABC-transporter-substrate-binding-protein
MRMLRSALAMSSVLALGLTACSTSATTTSSAPAPAETSASSSAPAESSAPAESSAPAEGDIPMGDGTQTIYLVSKGFQHRFWQAVKQGAEQAGEEFNYKVEFVGPENEQAVTQQLDQLRTALQSQPAAIGFAALDSGAAGPVLEEIQAANIPIIAFDSGVDSDIPLTTVSTDNRAAAAEAAKNMAELIGNEGTVGLVCHDQTSATGKQRCEGFQEWMQENAPDVKLLEPQYAFEVGLAANTAKAIIQANPDIAGIYGSNEASAIGTLQGAVESGADVVVVGFDSGKAQLDAIRNGDMAGAITQSPVKMGYETVVAAIKAIDGQELPKVIDSGFAWYDATNIDDPEIAANLYE
>NZ_CP019229.1|WP_141680069.1|1192386_1193154_-|LemA-family-protein
MDTVLIILIVLVVLALAVVLWGVGAYNGFVRSRNLIQESWRQIDVELNRRYELIPNLVETVRGYAAHERNTLEQITALRNTARSLATQTHGQPSEQRAAVEAELTTAVHNLLVSVEAYPDLKSNTNFLELQRELTDTEDRIAASRRFYNANVRDYNTRIESVPSNIIAGFAKFEKATYFEVNDPIVRQAPDVNFGEISQRPAAAPESQQQIQAPRTDAGAQPYQPPQRAQQPDVQPADAPPPQQEPGGYRPPYTS
>NZ_CP019229.1|WP_078919772.1|1193226_1194735_-|helix-turn-helix-transcriptional-regulator
MKKRRNSATVNFVTVDDDTPAPAGQEPGSFDPFSLGRRLRHLRKERGLTLAQVAEAAGLASSQLSLLENGKREAKVSHLQRLAAVYGATLGDLTAAVPSRRAQLEIELERLMRSPLARAKGLPVVRISPRMPMEVLEALVALHRELAHDAAERMATPEEARRANAQLRDEMRARDNYFGTIEQEAATLLRRCGYVAGPLSQHLIGEITAHLGFTLHHVGDLPHSTRSVMDLRSKRIYLPTSSSREHEPRSVLLQALGHHILGHAPPANYGEFLRQRIETNYFAAALLLPEEPTVRFLQEAKARRELALEDLRDAFAVSYEAAAHRFTNLATVHLDIPVHFQRVHESGTIYKAYENDGVAFPKDNLGAIEGQPACRYWTSREVFDVADKFNAFNQYTDTPTGTFWCTARVEQTSTGAFSTGIGVRYRDSKWFRGRDTRERSVSRCPDPTCCRRAPADLSSRWSGHAWPSARTHAHLLAALPPGTFPGVDDTEVYQFLDAHQGA
>NZ_CP019229.1|WP_068751590.1|1194838_1196113_+|isocitrate-lyase
MTDPMSAELLKYDWKINPRWSNVQRDYSAEDVVRLRGRVQEEHTLARRGAERLWEQLHSEDFVNALGALTGNQAVQQVKAGLKAIYLSGWQVAADANLSGHTYPDQSLYPANSVPQVVRRINNALLRADQIEHAEGIRTVEDWLVPIVADAEAGFGGTLNAYELMKAMIASGAAGVHWEDQLASEKKCGHLGGKVLIPTQQHERTLNAARLAADVAGVPTVIIARTDAEAATLLTSDVDERDREFLTGERTSEGFHKVRPGMEPSIARGKAYAKYADLLWMETGVPDLEAARTFAEAIKAEHPDQLLAYNCSPSFNWRKHLDDATIAKFQRELGAMGYAFQFITLAGFHALNYSMFDLAQGYATRQMSAYVELQEREFAAEERGYTATRHQREVGTGYFDTIAAAINPASSTTALEDSTESAQF
>NZ_CP019229.1|WP_068751755.1|1196174_1198367_+|malate-synthase-G
MHATHAPVGRLWVDRTLVDFLDREALPVAGVDRERFWAGFEEVFDRFTGRNRALLEERRRLQQAINEFHRAHPGRPDAGHYRSFLTRIGYLLPEATEVAARTTGVDREIAEVAGPQLVVPVTNRRFAINAANARWGSLYDALYGTDVIDDGDGAGREGRYNPVRGAKVIAWAREFLDAVAPLASGSHTDVAGYRAGRVFEAMLSSGQIVGLADPDTYAGFQGEPGAPDAILLAHHGLHLELRIDRQGRIGREDPAGIDDIVLESAVTAIMDFEDSVATVDGPDKVVAYRTWLQLNDGTAIEEMSKGGRQFTRTLADDRRFTRPDGTELRLPGRALMLCRNVGHLMTTPAVLDDEGQELPEGILDALVTSLCAMPGLRADARRANSRTGSIYIVKPKQHGPDEVAFTSDLFAAVEDVLGLPRTTLKMGIMDEERRTTVNLAACIAQAADRIIFINTGFLDRTGDEIHTSMEAGPMIRKAEMKQAAWMRAYEDWNVDVGIACGLPGRAQIGKGMWAKTDLMAEMVAEKIGHPASGATTAWVPSPTAATLHATHYHRVDARERQAGIAAGGGRATRDDLLEIPLATSTRWSPEERQEEVDNSCQSILGYVVRWIDQGVGCSKVPDITDTSLMEDRATCRISSQMLANWIRHGIVSEQYVLQSLKRMAAVVDAQNAGDRTYRPMTPREGGSFEDSIAWCAARDLVVQGTWSPSGYTEPILHRRRREYKARYRLS
>NZ_CP019229.1|WP_068751591.1|1198359_1198902_-|orotate-phosphoribosyltransferase
MTDRSDLIAHIKDLAVVHGRVTLASGKEADYYIDMRRVTLDGAASPLVGRVMNELVADLDFDAVGGLTLGADPVATAMLHARAAAGGRLDAFVVRKSAKEHGMQRRIEGTDVAGRRVLVVEDTSTTGGSALTAVEAVREAGGEVVAVAVVVDRGTGAAERVGDAGLEYRYAVDLADLGLS
>NZ_CP019229.1|WP_078919773.1|1198898_1199627_-|class-E-sortase
MGRMEAKRAADGASVTRSRRRLSPAVLVAIAVVTALLAAGGYLAWQVYGTTWLARDRAAGTVAELRASWAAATPTPTPTPDAPDADPQVPVPALPEPGEAAWILRIPSLGVEWPVVSGVEGRLLTEAVGWYPSTALPGQVGNTAIAGLRLTNGAPFERLLELREGDEVIIDTATATFTYRIVLAPAELTVQADESWVLDPVPGEPDTVPSQALLTLTTHEDLIDTPDRSVGFGVLEKAETTR
>NZ_CP019229.1|WP_068751593.1|1199657_1200713_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase
MTLLDDTLSAIVPASAEALAAAEARQLRLTKPAGSLGRLEEIGNRLAAIADACPPPLPARAVIGLFAGDHGVCAQGVSPWPQEVTVQMALNIASGGAAINAIARQVGAEVWVTDVGVAAEVPEHPGIRARNVRRGTRDFTVEPALTRDEARAALEVGIEAANEAIDAGADVLLTGEMGIGNTTPASALIAVFSRLHVTTVTGRGAGADDDMLTRKVRVIDDALTLHRPDPADPLGVLAAVGGLEHAALAGFILGAAARRIPVIIDGVIAASAACVAAGFDESVTGYLIAGHAGVEPGIKAALTWLDLQPLVDLDLRLGEGTGAALALPTVQAAARILSEMATFDSAGVAEG
>NZ_CP019229.1|WP_068751594.1|1200745_1201465_+|cobalt-precorrin-6A-reductase
MILILGGTAEGRRLAEALTGRAAVLSLAGRTRDPLTAGQVRLGGFGGVEGLRGYLREHGVTAVVDATHPFAAVMSRNAAAACAAEGVALLRLVRPSWASHPSAGSWHWVDGHGEAARRAAALGARPFLTVGRQHTADYVADLADADVLARVAEPPVAFLPARWTLVTSRGPFTLDGERELMAAHGIDVLVAKDAGGAHTDAKLSVAAERGAAVVMIRRPAAPAGVPEVADVAGALTWLG
>NZ_CP019229.1|WP_068751595.1|1201470_1203936_-|cobyrinate-a,c-diamide-synthase
MVSRLVIAAPSSGQGKTTVATGLMAALRARGLEVAPFKVGPDYIDPGYHGLATGRPGRNLDPFLCGEERIGALFAHGAAGADVAVIEGVMGLFDGRLGTGGFGSTAHVARLLDAPVVLVIDARHTSRSVGAVALGMARFDPRVRVAGVILNQVGSVRHAAEARAAVEEVGLPVLGVLPKALDIEAPSRHLGLVPVAERDDSRVAAMGDVVAAHVDVAALLAVAAAAPALDVVAWDPAREVSPPSDRRPVVAVAGGRAFTFRYPETDELLAAAGCRVVEFDPLVDSALPAGTAGLWLGGGFPEVYAGELAANEALMTEIRESVAGGLPTIAECAGLLYLCRSLDGRPMVGAVEADAAMGPRLTMGYRVAVSDRPTLLGRTGEEVTGHEFHRTTVTLAGAAKSAWLLDGRADGVAGENLHASYLHVHWAGHPQVAQRFADAVHRYPALGAGEGLSRWHDSTRTRALTRPDFDVESCHLLKPNPPPGPEPDLLHHGDRDLAPGLIDLAVNVRVPTTPAWLAEEIFGDIDLAAYPDPTPARDALAAHHGVDPAMVLPVAGAAEAFTLIARALPGDALIVHPQFTEPEAALRAAGRDPRRHVLSRDTGFRLIPSQVPAGELTIVGNPTNPTGVLHRADDLAALPAATLVVDEAFMDAVPGEPETLIAPSMPGRLVLRSLTKTWGLAGLRIGYVVGDPALIERLAAQQPPWSVSTPAIRAAMACTSARATAEAARLADEAVVAREDLAVRLTDVGVAVVPGRAPFVLADTTALSASSLRGPLAERGFAVRRGETFPGLGPTWLRFAVRTPDVHRRLATALAELGGHP
>NZ_CP019229.1|WP_068751756.1|1203929_1204517_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MGAPRGGVAVSAPTTRELRQRPIVAVHTGDGKGKTTAALGMALRSWAQGWDVGVYQFVKSAKWRTGEQEAFASLPERGGLTWEKMGTGWSWSRAHTAVDPAEQAREGWRSIRQGLAEERHRFWLLDEFTYPLAWGWIDVSEVVEALGSRPGRQHVVITGRRCPQELIDAADLVTEMALVKHPFQQGQRGQAGIEW

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Crispr_ID: NZ_CP019229_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_2

1230886-1230973

Orphan

Consensus_repeat	Method
CCGAGTCTCGAAGTCGCCGCCCC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP019229_2

>merge|NZ_CP019229|2|1230886-1230973|CRISPRCasFinder
CCGAGTCTCGAAGTCGCCGCCCCCTCGCTCACTGAGGTCGCGGGCCGACGGCGCAGCCGGCGCGCCCGAGTCTCGAAGTCGCCGCCAC

>NZ_CP019229|2|2|1230886-1230973|CRISPRCasFinder
CCGAGTCTCGAAGTCGCCGCCCC	CTCGCTCACTGAGGTCGCGGGCCGACGGCGCAGCCGGCGCGC
CCGAGTCTCGAAGTCGCCGCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068751623.1\|1238420_1238891_+\|DUF2892-domain-containing-protein	unknown	unknown	gnl\|CDD\|378561
NZ_CP019229.1\|WP_068751619.1\|1233698_1234946_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|162098
NZ_CP019229.1\|WP_068751617.1\|1228540_1230814_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|185053
NZ_CP019229.1\|WP_078919775.1\|1220047_1222366_+\|RecQ-family-ATP-dependent-DNA-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP019229.1\|WP_068751618.1\|1231224_1232268_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP019229.1\|WP_068751614.1\|1226301_1226649_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|223672
NZ_CP019229.1\|WP_068751621.1\|1235364_1235970_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_078919780.1\|1241780_1244225_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187655
NZ_CP019229.1\|WP_068751620.1\|1234954_1235314_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP019229.1\|WP_078919777.1\|1236183_1238289_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319850
NZ_CP019229.1\|WP_068751609.1\|1215813_1218204_-\|precorrin-3B-C(17)-methyltransferase	unknown	unknown	gnl\|CDD\|381173
NZ_CP019229.1\|WP_078919778.1\|1238962_1240153_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP019229.1\|WP_068751616.1\|1227748_1228435_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP019229.1\|WP_141680080.1\|1219027_1219783_-\|precorrin-2-C(20)-methyltransferase	unknown	unknown	gnl\|CDD\|381172
NZ_CP019229.1\|WP_068751615.1\|1226769_1227597_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381358
NZ_CP019229.1\|WP_078919776.1\|1232260_1233625_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP019229.1\|WP_068751610.1\|1218200_1219031_-\|precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl\|CDD\|200107
NZ_CP019229.1\|WP_068751613.1\|1223759_1225217_-\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|234838
NZ_CP019229.1\|WP_078919779.1\|1240231_1241689_+\|L-fucose/L-arabinose-isomerase-family-protein	unknown	unknown	gnl\|CDD\|238323
NZ_CP019229.1\|WP_141680070.1\|1222762_1223200_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068751623.1\|1238420_1238891_+\|DUF2892-domain-containing-protein	gnl\|CDD\|378561	pfam11127, DUF2892, Protein of unknown function (DUF2892). This family is conserved in bacteria. The function is not known.	6.9094e-06
NZ_CP019229.1\|WP_068751619.1\|1233698_1234946_-\|MFS-transporter	gnl\|CDD\|162098	TIGR00900, multidrug_transporter, H+ Antiporter protein. [Transport and binding proteins, Cations and iron carrying compounds].	1.61446e-53
NZ_CP019229.1\|WP_068751617.1\|1228540_1230814_+\|beta-glucosidase	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	0
NZ_CP019229.1\|WP_078919775.1\|1220047_1222366_+\|RecQ-family-ATP-dependent-DNA-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	5.47346e-129
NZ_CP019229.1\|WP_068751618.1\|1231224_1232268_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	2.66185e-84
NZ_CP019229.1\|WP_068751614.1\|1226301_1226649_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|223672	COG0599, COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown].	2.26091e-20
NZ_CP019229.1\|WP_078919780.1\|1241780_1244225_-\|hypothetical-protein	gnl\|CDD\|187655	cd08952, KR_1_SDR_x, ketoreductase (KR), subgroup 1, complex (x) SDRs. Ketoreductase, a module of the multidomain polyketide synthase (PKS), has 2 subdomains, each corresponding to a SDR family monomer. The C-terminal subdomain catalyzes the NADPH-dependent reduction of the beta-carbonyl of a polyketide to a hydroxyl group, a step in the biosynthesis of polyketides, such as erythromycin. The N-terminal subdomain, an interdomain linker, is a truncated Rossmann fold which acts to stabilizes the catalytic subdomain. Unlike typical SDRs, the isolated domain does not oligomerize but is composed of 2 subdomains, each resembling an SDR monomer. The active site resembles that of typical SDRs, except that the usual positions of the catalytic Asn and Tyr are swapped, so that the canonical YXXXK motif changes to YXXXN. Modular PKSs are multifunctional structures in which the makeup recapitulates that found in (and may have evolved from) FAS. Polyketide synthesis also proceeds via the addition of 2-carbon units as in fatty acid synthesis. The complex SDR NADP-binding motif, GGXGXXG, is often present, but is not strictly conserved in each instance of the module. This subfamily includes KR domains found in many multidomain PKSs, including six of seven Sorangium cellulosum PKSs (encoded by spiDEFGHIJ) which participate in the synthesis of the polyketide scaffold of the cytotoxic spiroketal polyketide spirangien. These seven PKSs have either a single PKS module (SpiF), two PKR modules (SpiD,-E,-I,-J), or three PKS modules (SpiG,-H). This subfamily includes the single KR domain of SpiF, the first KR domains of SpiE,-G,H,-I,and #J, the third KR domain of SpiG, and the second KR domain of SpiH. The second KR domains of SpiE,-G, I, and #J, and the KR domains of SpiD, belong to a different KR_FAS_SDR subfamily. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type KRs have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	0.00663596
NZ_CP019229.1\|WP_068751620.1\|1234954_1235314_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.19635e-15
NZ_CP019229.1\|WP_078919777.1\|1236183_1238289_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319850	cd07552, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase. Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP019229.1\|WP_068751609.1\|1215813_1218204_-\|precorrin-3B-C(17)-methyltransferase	gnl\|CDD\|381173	cd11646, Precorrin_3B_C17_MT, Precorrin-3B C(17)-methyltransferase (also named CobJ or CbiH). Precorrin-3B C(17)-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. This model includes CobJ of the aerobic pathway and CbiH of the anaerobic pathway, both as stand-alone enzymes and when CobJ or CbiH form part of bifunctional enzymes, such as in Mycobacterium tuberculosis CobIJ where CobJ fuses with a precorrin-2 C(20)-methyltransferase domain, or Bacillus megaterium CbiH60, where CbiH is fused to a nitrite and sulfite reductase-like domain. In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyzes the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1). In the corresponding anaerobic pathway, CbiH carries out this ring contraction, using cobalt-precorrin-3b as a substrate to generate a tetramethylated delta-lactone.	1.43887e-112
NZ_CP019229.1\|WP_078919778.1\|1238962_1240153_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.04698e-105
NZ_CP019229.1\|WP_068751616.1\|1227748_1228435_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.13449e-06
NZ_CP019229.1\|WP_141680080.1\|1219027_1219783_-\|precorrin-2-C(20)-methyltransferase	gnl\|CDD\|381172	cd11645, Precorrin_2_C20_MT, Precorrin-2 C20-methyltransferase, also named CobI or CbiL. Precorrin-2 C20-methyltransferase (also known as S-adenosyl-L-methionine--precorrin-2 methyltransferase) participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. Precorrin-2 C20-methyltransferase catalyzes methylation at the C-20 position of a cyclic tetrapyrrole ring of precorrin-2 using S-adenosylmethionine as a methyl group source to produce precorrin-3A. In the anaerobic pathway, cobalt is inserted into precorrin-2 by CbiK to generate cobalt-precorrin-2, which is the substrate for CbiL, a C20 methyltransferase. In Clostridium difficile, CbiK and CbiL are fused into a bifunctional enzyme. In the aerobic pathway, the precorrin-2 C20-methyltransferase is named CobI. This family includes CbiL and CobI precorrin-2 C20-methyltransferases, both as stand-alone enzymes and when CbiL forms part of a bifunctional enzyme.	3.56308e-70
NZ_CP019229.1\|WP_068751615.1\|1226769_1227597_+\|aldo/keto-reductase	gnl\|CDD\|381358	cd19132, AKR_AKR5D1_E1, AKR5D and AKR5E families of aldo-keto reductase (AKR). 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	2.4027e-127
NZ_CP019229.1\|WP_078919776.1\|1232260_1233625_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.49709e-106
NZ_CP019229.1\|WP_068751610.1\|1218200_1219031_-\|precorrin-4-C(11)-methyltransferase	gnl\|CDD\|200107	TIGR01465, Precorrin-4_C11-methyltransferase, precorrin-4 C11-methyltransferase. This model represents precorrin-4 C11-methyltransferase, one of two methyltransferases commonly referred to as precorrin-3 methylase (the other is precorrin-3B C17-methyltransferase, EC 2.1.1.131). This enzyme participates in the pathway toward the biosynthesis of cobalamin and related products. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	6.11014e-123
NZ_CP019229.1\|WP_068751613.1\|1223759_1225217_-\|cobyric-acid-synthase	gnl\|CDD\|234838	PRK00784, PRK00784, cobyric acid synthase.	0
NZ_CP019229.1\|WP_078919779.1\|1240231_1241689_+\|L-fucose/L-arabinose-isomerase-family-protein	gnl\|CDD\|238323	cd00578, L-fuc_L-ara-isomerases, L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose in glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in various oligo- and polysaccharides in mammals, bacteria and plants. AI catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion to D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon source. AI can also convert D-galactose to D-tagatose at elevated temperatures in the presence of divalent metal ions. D-tagatose, rarely found in nature, is of commercial interest as a low-calorie sugar substitute.	4.68639e-84

>NZ_CP019229.1|WP_068751617.1|1228540_1230814_+|beta-glucosidase
MTDAPAYRDPALSVEDRVEDLLGRLTLEEKAGQLTQYFYFGRPDATDAVEVDLDSLPDEQRQFLEYPAYVERELHAGRVGSLLFVKNAAQANRLQRQAMDANRHGIPLIFGYDVIHGFRTTFPVPIAVAASWDPDVAEQGQRVAAREARAVGINWTFAPMVDIARDPRWGRIIEGAGEDPCLGGAMAAAQVRGFQGDGGPESLLAGPKHFAGYGAARGGRDYEDSDISDAELRNVYLPPFKAAIDAGAKNVMSAYMDLNGVPASGSRWLLTDVLRDELGFDGFVVSDANAVRSLETQHFARDLTDAGARAVHAGLDMEMAMYDAAYARLPQAVADGLVDEATIDLAVRRVLTAKFAAGLFENPFVDESTTASILGDSTHRDVAQAAAERTAVLLKNDGALPLRAPSSIAVLGDLADSQRDILGPWIFDFDVTESVTILDGIRRRAGEGTRVEFAPATAVATRLFPSMFDAHEAGQLPRTPEGFDEDAELERAVALAVESEVAVVVVGQPQNMIGEKASVSTLDLPGRQLELLQRVHATGTPMVVLVMSGRPLDLRWADANADAIVQIWYPGVRGGDAVARVLFGDVSPAGRLPFTWPRHVGQVPMVHSHYRTFQPEEADKRYWDEESTPLYPFGHGLTYATVEYSDLRAPSSIAVGETGTVAVTLTNTSEVDSDEVAQLYIHQRYGTSTRPVRELKGFRRVHVPAGASVDIEFELGPDQLRYWSAATRTWVQDATVIDVFVGGSSACELTTSLEVTA
>NZ_CP019229.1|WP_068751616.1|1227748_1228435_-|TetR/AcrR-family-transcriptional-regulator
MGRSLKEVAVSTTPSKRGPYAKSAEKRAAIAKAAYDVVMEVGHPQLTTAAVAARAGMLERTMLYHFPTRDHLLVAAIEYFEGFIDGEGQDVDVERPLAPPGEFRDLIDHLAHRSPGEDKRLQLQVALASAAQDPAHPAHAFFQRHYERVMAEMVELMKARQAAGLAHPDRDPVRMARQFVAVWDGLQQNWLIRRDFDLTEEITEAFREISGQNAMEARAAVQDLLNRI
>NZ_CP019229.1|WP_068751615.1|1226769_1227597_+|aldo/keto-reductase
MTTLAPRIPLTGGTAIPAIGVGTWPLNDDEVRAMCLTAFEIGYRLVDTAENYRNEAGVGRAVRESGLAREDVFVTTKFNKKWHGDAVAGVEGSLGRLGLEYADLVLIHWPNPDQDLYVRAWEGLIEARERGLTKAIGTSNFKPEHLQRLIDATGVAPEVNQIQCNPFTPRTQERAFHAEHGILTESWAPLAAGNGLAEHPTVSDVAAAHDVTAAQVVLAWHIQQGLLPIPKSSNRERLAENFAALDVRLTDDEVRALTALENPDYRVADSDRFGH
>NZ_CP019229.1|WP_068751614.1|1226301_1226649_-|carboxymuconolactone-decarboxylase-family-protein
MTTHEHGKKVLQDLQGPAKELRSRIPEVYAGYSAMHKAVLGPGALDTKTKELIALAIGVTDKCDGCIASHARGAARAGATADEVAEALGVAILMRGGPATVYGPRAMDAFLEFLE
>NZ_CP019229.1|WP_068751613.1|1223759_1225217_-|cobyric-acid-synthase
MTGILIAGTSSDAGKSLVVTGLCRAARRRGIDVVPFKAQNMSNNSMVCADGAEIGRAQYLQAIAAGKTPTSAMNPVLLKPGSDRRSFVVLRGEPAGALEAGEYATGRRLLAEAAHEAYRELVAAHELVICEGAGSPAEINLRDGDYTNMGLARAFDLPVVLVGDIDRGGVLASIYGTWGLLDDDDRALLAGYLINKFRGDQAILDPGLTELTRRCGLPSFGVLPWLPGVWLDGEDALEVGRWRGDARPAASTGSGTLRVAVVRLPRISNATDVDALAQEPGVDVVVTTDPATVAAADLAVLPGSRSTLTDLAWLRETGIAAAIEARAEEGRPVLGICGGFQMLTRTITDPVEAGHAGAVPGLGLLPADTVFHPDKVLGRPSGSWRGHDVEGYVIHHGRVRVDDGHEEFLEGVHAGPVWGTMWHGSLESDGFRRAWLQEVASLAGRNWAPADGAPGFAARRETMIETVADALEAHADLDRLLALAR
>NZ_CP019229.1|WP_141680070.1|1222762_1223200_-|hypothetical-protein
MREIVRQARTADPVGFRDRRTALANSDGFEQIMRGSSSEAERVYLDFFTAVSSDAEIARFVEATEGKFIAVSGSGADLAVEWVDTPPVSTRALDCWQAYVASYSFFAASTAICGVVTIASGPGGIACALAFWGIGTLPDLNDACD
>NZ_CP019229.1|WP_078919775.1|1220047_1222366_+|RecQ-family-ATP-dependent-DNA-helicase
MHTREFWLEEPPADEWELPPDDGPGGRDDPGRLPDPPAAQARPSLRAAAAAAPPAGRVAHRGSAGLRDEALDALRSLTGRPDAEFHDGQFEAIEALVDGHRRALVVQRTGWGKSAVYFISALLQRRAGAGPALIVSPLLALMRDQVAAAERAGVRAVAINSANVTEWSDIEQLLDADAVDVLLVSPERLVNPRFREQQLPRLIAAMGLLVIDEAHCISDWGHDFRPDYRRIRTLIAELPDEIPVLATTATANERVVADVVEQMGIGGHEVFTLRGPLARTSLRLGVLDLGTAWRRLAWLSEHLSELPGSGIVYCLTVAAAEDTAAHLAKAGHSVLPYTGRTDAAERLEAETALKENRVKALVATSALGMGFDKPDLGFVVHLGAPSSPVAYYQQVGRAGRATDNADVLLLPGPEDRDIWHFFATNAMPTQARADAVLGALAHEGAPLSVAALESRVDLRRGQLELLLKVLAVEGAVEYVQGGWVATRAEWIYDAERYGRIAAARRAEQDAMLGYEAGRECRMAFLTAGLDDPHAAPCGRCDVCAGVWFPTGISADDEAAAKAGVDRVGVELAPRALWPGGLDRLGVTDGGKKLSGKIAPDQRLEPGRVVARLTDLGWGGTLRDLFAPDRDGRPVDAEVPEGLAQASLRVLREWDWTQRPTSVAWVPSISRPRLVESLATGIATAGRLRLLGPLELSPTATPLDRSTNSAFRVRDVWNRFRVRPAMAEALAAQTGPVLLVDDLVESRWTLTVAGRLLRRAGAPAVLPFALGTY
>NZ_CP019229.1|WP_141680080.1|1219027_1219783_-|precorrin-2-C(20)-methyltransferase
MPPVSARLLVGVGVGPGDPELITVKAVRGLEAADAILVPATEESGDGPGRAERIVQAACPDAASRIVRVPFSMADKSGVSPRRKQAWLTSAQAAVDAFVDGAATVAFATVGDPSVYSTFSYLAAHVVEQLTDVEIEVIPGITAMQALAAASRTPLVEGQEVLALVPVTAGMDRLREVLAVADSTVAYKGGRRLPEVAELLRGEGRDAVMGVDVSLPNQRLVRLSDLADGESAPYFSTVLAAPTRSATGGRL
>NZ_CP019229.1|WP_068751610.1|1218200_1219031_-|precorrin-4-C(11)-methyltransferase
MSGKVVFVGAGPGAADLITVRGARVIAEADIIIWASSLVHPGIVAGAKPGAELVDSASASLEDIEPLYRRACDEGLLVARVHTGDPAIYGATAEQRDLIRSLGLEFESVPGVSAYSAAAARMEVELTVPEVSQSLVLTRLEGGRTPMPPRETVRGFAAHGTTMALYLSAARNKALQEELLAGGYPPETPCIVGYQVSWPDELMLCCELKDLSETMREHKLWKHTVVLVGPALAEGPLATRSHLYHPGFRHEYRAAEPEAQADLRAHGTRGVLEEDR
>NZ_CP019229.1|WP_068751609.1|1215813_1218204_-|precorrin-3B-C(17)-methyltransferase
MIHVHGYLGEISPATRSLAGRVALVVGGRRHLDALGVPDERRVVLGALSPAVERLKALPDGDDALVLASGDPGFHGIVRRLREEGLDLAVTPAVSSVAAAFAAVALPWDDALVVSAHGRPIDDAVAATRRHPKVAVLTGPGAGVRELAAALEGWSRRYVVAERLGEPDQRVRELSAEEAAVAEVAEPNVVLILDDSVPAERGADGPVVGQVTNSEAARRHADAIDAALGAATRRYDGPAAEGLVRAWRECDLIVSHLALGATARILAPLLADKKSDPGVVVVDEAGRFAVPLVGGHVGGANELARRIADATGGTPVLTTATDALNIPALDTLGWAYRGDVAGVTRAILDGRPVRVEKSQPWPLPPLPANVSADAEDPVATIVVTDSRAEVPHPLAEVPRSGLEAYESQPLRRTVVLHPRSLVVGMGCNRGTDVAHLRDLLERTLAEHGLALESVAAITTVDLKAGEIGLLQLVKQLGVKLIDYPADELAAQPVPTPSAMVEGHVGTPSVAEASVLAHGAELIVAKQRSTDATCAVGRIPARGRLSVVGLGPGVRDLLTPRAKQRLQQATFVVGYGPYVKQIRDLIRPGVRVMASKMGTEEARTAAAIEAARAGENVALVCGGDPAVYAMASPVLEQGTDGIDVDIVPGVTASLAVSAILGAPLGHDHATISLSDLHTPWPNIERRLQGAAVGDFVVALYNPRSRTRTAHLPRALEILGAHRSPETPVAVVQQACRPRQKVIMSTLAEFQPEWVDMNSLVVVGSSTTRFVTSGGGRRLIVTPRDYQWMPDTVEEVDA
>NZ_CP019229.1|WP_068751618.1|1231224_1232268_-|HlyC/CorC-family-transporter
MLDATAILIAIALLIGNAFFVGAEFALIAARRTQIEPRAAAGSRAARITLRAMERVSLMMAGAQLGITMCSLGLGAIGEPAVAHALEIPLAAVGITGAALHTVSFIIALAIVVFLHMVLGEMLPKNIAIAGPERSALLLGPILYGIVVVLRPLIWLLNWIANAVLRLLRVEPKEEVASAFTADEVAAFIAESREEGLLEDREHQLLSGSLTIGTETVEAVMVPLDSLQTVPRGASPSDVETAFVRTGFSRFPVTAEDGEVLGYVHLKDFLGLSDDEASRPLDDHVVRPLATIAKDTTLEAALAAMQAGGTHFALVVDGDDTIGAAMLEDVVERLIGEVKDAATVSRG
>NZ_CP019229.1|WP_078919776.1|1232260_1233625_-|HlyC/CorC-family-transporter
MIVEWLLLAAVVVLIAANATFVAAEFALVTVDRPTVSRLSETDAKAASLREALRTMSTQLSGAQLGITITSLVVGFIAEPSIAALLEVPIEAVGLPEETASVIAFTAAFLIATVVQMVFGELVPKNWAIAEPLKVGRAVVGFQRAFTWVSRPLLWFLNGTANRLVRAFGMEPQEELASARSAQELGSLAARSARQGLLGEDLARRLEHSVALGERTASDAMTPRPRVRFLELDQTAADVLDAVRATGHARFPVTGDSVDDVRGVVHFKDAVAVPAAERATTPVAGLIRPMRAVPSTMPLGPVLEVLRRGVQMAVVVDEYGGTDGIVTLEDVVEEIVGEIDDEQDRPTRAYRELGERRWSLSGLLRPDEAGETLHLELPEGRESDTLGGLITEELERFPRIGDQVVLAVRDESRPDDDGLPSPAQARLTVTRLDGWRVDRLTLAVEDLEEGEQNA
>NZ_CP019229.1|WP_068751619.1|1233698_1234946_-|MFS-transporter
MLSVLRHRTYRHLFAAQVIALLGTGLLTVALGLLALDVAPDRAGAVLGLAMTIKMVAYVGVAPVISALVARLPRKPLLITADLVRAAVALSLPLVTEAWQIYVLIFLLQSASATFTPAFQALIPTVLPIEREYTRALSLSRLAYDMEALVSPMLAALLLTVAGYQNLFLGTVAGFATSSVLVAATTIPRVAAPPAAPFLSRLTGGTRQFWASVELRGLIGINLVVAAATAMVIVNSVVIVGTDLGRGHDDVALLLAAYGAGSMLVALAVPRLLDRRPDLRVMLAGAAVLPMALAAAAAVLAWVDAARAWPLLLGLWFAVGAATSAVLTPSARLLRRNSTEQTCPAVFAAQFSLSHACYLVTYPVAGVGGALLGLPGVALVLVAVAVPGLVWAARAWAPNRSTIPEPGRSAHMIDA
>NZ_CP019229.1|WP_068751620.1|1234954_1235314_-|winged-helix-turn-helix-transcriptional-regulator
MHADKKINSVPAEFVDLAAEVLSLLSDPTRIRIILTLDAAGELSVGELAQAVAKNPSGVSQHLARLRMARMVTTRQDGTRVLYKLADEHALSVVIEAVRQAEHSVASAGQLPLHHSHEA
>NZ_CP019229.1|WP_068751621.1|1235364_1235970_-|hypothetical-protein
MPRLRPALLAAVCSASLTLAACSVPEAGPATSQAVSSRSVATVDAGTLLAAQGLEGRSGREVVEALDQLDAARPLPLAASVRYDEVLLSDGASQAALPLEGDEFYLSLAPYVTRTHECYFHNLGTCRGEMAGEQVHVTITTDDGDVLVDEDATTYANGFVGFWIPKDVAGTVVVTADGKRAETRFSSDPEGPTCLTTLQLA
>NZ_CP019229.1|WP_078919777.1|1236183_1238289_+|copper-translocating-P-type-ATPase
MEHTGHHDHSTHGQAMPQGHAHSAVDEKQVHSHGEHAGHSTAMFKNRFWASLALTIPVVIFSPMVAHLLGYHLPEFPGSTWIAPILGTVIFAYGGVPFLKGGWRELKTRQPGMMLLISLAITVAFVASWVTTLGVGGFELDFWWELALLVTIMLLGHWMEMRALGAASSALDALAELLPSEAERVTDDGTVVVPIAELAVDDVVLVRAGARVPADGTIVDGAAEFDESMITGESRPVARGEGERVVAGTVATDNTVRVRVEATGDDTALAGIQRMVADAQASSSRAQALADRAAALLFWFALGAGILTAIAWTVLGSPDDAVVRTVTVLVIACPHALGLAIPLVIAISTERAAKNGVLIKDRMALERMRTIDVVLFDKTGTLTEGAHAVTGVAAAGASEAELLSLAAAAEADSEHPVARAIVAAAAAHPKASGMRRRATDFSASTGRGVRATVDGAAIQVGGPTLLRELGLETPSALTEKTGSWSGRGAGVLHVIRDGEVIGAVAVEDTVRAESRAAVRALQDRGVRVAMVTGDARQVADAVGAELGIDEVFAEVLPQDKDTKVTELQGRGLTVAMVGDGVNDAPALARAEVGIAIGAGTDVAMESAGVVLAGNDPRAVLSMIDLSRASYRKMIQNLVWAAGYNIVAVPLAAGVLAPVGVVLSPAVGAVLMSLSTIIVALNAQLLRRLDLDPARLSAGGAA
>NZ_CP019229.1|WP_068751623.1|1238420_1238891_+|DUF2892-domain-containing-protein
MSNADHVRSSTDDDVQRRLDEERLQRVTDLVNAPSDVITRHIEDLDKAWDVERVLEANASSLILLSLGLSRVHSAKWLWLATAVPAFLLQHAIQGWCPPMEVIRRLGVRTRKEIEVERTALKALRGDFRDLTFDGDDPAAAARAALEAAEREQKGR
>NZ_CP019229.1|WP_078919778.1|1238962_1240153_-|LacI-family-transcriptional-regulator
MRLYQEVRRIRRVGAVSDQLIEIEAVQICWPYSGCWRVGFRRVQFVPRAGEGRGVAKPGKVTLSDVAKAAGVSSGTVSNTINRPESVADATRRRVQAAIRQLGFVPNEGAARLRSGSSRLLGLVVPDIASSFYAEIAKGVARRAEEHGHAMLLFDTGDDLDREVRQLETLARHRSIGALIAPRMADERHLRRLRALDMHLVLIDRPASEHDGCSVSIDDLQGGRMAARHLVVLGRRRLAFVAGPVGVPQAERRLQGFRDAVAADEVSVEPAVVHADSSDFLGGGEAARALLAMDPRPDGVFCVNDQLAVGVVNELTRAGLRVPQDVAVVGYGDTSVARSASVPLTTVRQPMSDLGRAAVDHLIRESEGVAESRMHHHSSTVFQPSLVVRESAPLPE
>NZ_CP019229.1|WP_078919779.1|1240231_1241689_+|L-fucose/L-arabinose-isomerase-family-protein
MSIIERRKPLTARVGIVSVGHHVYWGQFEGLLEDMHRKAAVLEGKVACHGVEVVNFGLLDEAQGTYATLPRIRAADLDLLLVDMVTYATSSTFGALIRALDIPVVLVALQPRAALDYANATTYMQLSNDDFCSVPEFAAVAVRMGKRPPEVIIGTLHDDPVADAEIAEWCQIAKVYRSLRTARIGLMGHVLEAMLDMHTDPTALTSAFGSHVVLCEPEDILRHWSDPDPALVSAKKEEILEFFDTPDPVSDPITMRLTDGDLHTAARAAVALDGFVEEKNLDGLAYYYEGLPESETRTLMTNLIVGNSLLQAAGFPMCGEFDIKTCVAMMVMDRLEIGGSFAEFHPIDFERDAVLVGHDGPHHINIAEGRPAIRSLRKYHGKPGSGASVEFNIKEGPITMLGNTITSDGKFKFVVAEGESLRLPVPPTGNTNTLGRFRPDVRTFLKRWVAEAPTHHYALGVGHHAETISKVADVLGIESVVVAQD
>NZ_CP019229.1|WP_078919780.1|1241780_1244225_-|hypothetical-protein
MSRPTALRRANLEVSLKPFADFGAKTLSSTVARIFDDWSVLLAAAEECSVLLWASDGSEILDWAGDLDQGFEWARFIGFNNTETAPYGEWKPPRRRAVPFAEHTPDVTYRDLARLVAEIKAEGRRRGIPTQVGATFDPGPEFAPSEFKYHRHPEIVARGEDVGIGPIIAMVRHFSVLSADDHAYAAFPTGIPEGTTFGEFLGRQAQDYLAALGFDYLWLSNGFGFSSYAWSELGESFDGERFAAERTPELRERALGFWADLSRHLTFPVQVRGTNHTAGIDIGADSVPALEVYERGYISSPPPNSPWGPLNEDFGIEITGFMSRIAMLPADAEGYRFRFYANDPWFWQQPWWDFYHREPFDIYLPLSIARLDADGRTQPPDEVNVLSIDTCHGVLDDRCGREVSGHVVTALEAHPDEAGPLVWVYPFREYHQAMAADPTSINRPHFEDWYLTSAVNAGLPLNTVVSTDNLAVAVANGAVDGRVLVVPAGALTAAVVEHLRRHAAAGGTVLAYGAVSAVGADGREFLGLEVADGGVAGTLSLTGVDEAGSGLPVAHAARLSAGPVTEVAAPGGATVVASARSEDGERVYASDRPLGQGRVMWVRGSSPVTYSDPDDRGVRQHQSPDPERYAHPGEVMLRLLRRAGIHVSHDLRGPASGRVVQAIHRHDNAYWFSGYLPDTTTSVRLRLPGGAPLLQQREAWMEEGVSVHQLPKSFHVECRVLVDQAAAGVVKCRDVAPFPAFMTRGISVSGLSNARVTVLLPRRTGAVEATVAGHVVDLNAAPEPGGAVTWRRDGQDVIVDGLTGEITVMWEETR

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Crispr_ID: NZ_CP019229_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_3

1282686-1282822

Orphan

Consensus_repeat	Method
AGGGCAGGCGCAACGACGGAGGGCAGGCGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP019229_3

>merge|NZ_CP019229|3|1282686-1282822|CRISPRCasFinder
AGGACAGGCGCCCAGCCTTAAGGCAGGCGCAAGGGGCACGCCTGCGCTCCAGGGCAGGCGCAACGACGGAGGGCAGGCGCCGCGACGGAGGGCTGGCGCCACGACGGAGGGCAGGCGCCACGACGGAGGGCAGGCGC

>NZ_CP019229|3|3|1282686-1282822|CRISPRCasFinder
AGGACAGGCGCCCAGCCTTAAGGCAGGCGC	AAGGGGCACGCCTGCGCTCC
AGGGCAGGCGCAACGACGGAGGGCAGGCGC	CGCGACGGAGGGCTGGCGCCACGACGG
AGGGCAGGCGCCACGACGGAGGGCAGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068751647.1\|1270662_1271289_+\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_CP019229.1\|WP_068751649.1\|1276309_1277269_+\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|133428
NZ_CP019229.1\|WP_068751663.1\|1290458_1291433_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP019229.1\|WP_068751660.1\|1286045_1288604_+\|glycogen/starch/alpha-glucan-phosphorylase	unknown	unknown	gnl\|CDD\|376320
NZ_CP019229.1\|WP_068751653.1\|1279173_1280202_+\|L-threonine-3-dehydrogenase	unknown	unknown	gnl\|CDD\|180054
NZ_CP019229.1\|WP_068751664.1\|1291429_1292479_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP019229.1\|WP_068751661.1\|1288655_1289450_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP019229.1\|WP_078919786.1\|1292508_1293351_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP019229.1\|WP_078920426.1\|1285282_1285963_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381700
NZ_CP019229.1\|WP_068751658.1\|1284428_1285280_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NZ_CP019229.1\|WP_068751657.1\|1283751_1284432_+\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NZ_CP019229.1\|WP_068751650.1\|1277265_1277835_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380110
NZ_CP019229.1\|WP_068751654.1\|1280209_1281409_+\|glycine-C-acetyltransferase	unknown	unknown	gnl\|CDD\|235893
NZ_CP019229.1\|WP_068751656.1\|1282954_1283755_+\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NZ_CP019229.1\|WP_141680074.1\|1281590_1282565_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227645
NZ_CP019229.1\|WP_068751662.1\|1289442_1290462_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP019229.1\|WP_141680073.1\|1278152_1279283_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238570
NZ_CP019229.1\|WP_068751648.1\|1271348_1273919_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP019229.1\|WP_068751651.1\|1277831_1278113_-\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NZ_CP019229.1\|WP_068751760.1\|1274107_1276270_+\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|131508

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068751647.1\|1270662_1271289_+\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.96672e-17
NZ_CP019229.1\|WP_068751649.1\|1276309_1277269_+\|L-lactate-dehydrogenase	gnl\|CDD\|133428	cd05292, LDH_2, A subgroup of L-lactate dehydrogenases. L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed predominantly of bacterial LDHs and a few fungal LDHs. Bacterial LDHs may be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	8.82898e-153
NZ_CP019229.1\|WP_068751663.1\|1290458_1291433_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	3.0326e-64
NZ_CP019229.1\|WP_068751660.1\|1286045_1288604_+\|glycogen/starch/alpha-glucan-phosphorylase	gnl\|CDD\|376320	pfam00343, Phosphorylase, Carbohydrate phosphorylase. The members of this family catalyze the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin.	0
NZ_CP019229.1\|WP_068751653.1\|1279173_1280202_+\|L-threonine-3-dehydrogenase	gnl\|CDD\|180054	PRK05396, tdh, L-threonine 3-dehydrogenase; Validated.	0
NZ_CP019229.1\|WP_068751664.1\|1291429_1292479_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	5.69948e-50
NZ_CP019229.1\|WP_068751661.1\|1288655_1289450_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.99449e-127
NZ_CP019229.1\|WP_078919786.1\|1292508_1293351_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.86901e-53
NZ_CP019229.1\|WP_078920426.1\|1285282_1285963_+\|hypothetical-protein	gnl\|CDD\|381700	cd19365, TenA_C-like, uncharacterized TenA_C proteins. This family of TenA proteins belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect. This family includes mostly uncharacterized TenA_C- like proteins.	3.7228e-79
NZ_CP019229.1\|WP_068751658.1\|1284428_1285280_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	4.73961e-106
NZ_CP019229.1\|WP_068751657.1\|1283751_1284432_+\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	7.53499e-56
NZ_CP019229.1\|WP_068751650.1\|1277265_1277835_-\|hypothetical-protein	gnl\|CDD\|380110	pfam18085, Mak_N_cap, Maltokinase N-terminal cap domain. Glycogen is a central energy storage molecule in bacteria and the metabolic pathways associated with its biosynthesis and degradation are crucial for maintaining cellular energy homeostasis. In mycobacteria, the GlgE pathway involves the combined action of trehalose synthase (TreS), maltokinase (Mak) and maltosyltransferase (GlgE). The N-terminal lobe can be divided into two subdomains: a cap N-terminal subdomain comprising the first 88 amino acid residues. This entry is for the cap N-terminal domain found in mycobacterial maltokinase (Mak), (EC:2.7.1.175). The N-terminal cap subdomain and the C-terminal lobe are predominantly acidic, the intermediate subdomain is enriched in positively charged residues. A structural search with only the first 88 amino acid residues of Mak, corresponding to the N-terminal cap subdomain of maltokinases, unveiled a resemblance with proteins displaying the cystatin fold and a remote similarity with the N-terminal domain of the serine/threonine protein kinase GCN2. Conservation of the cap subdomain in maltokinases (including the bifunctional TreS-Mak enzymes), in particular of the residues in the proximity of the P-loop, together with the potential flexibility of this region, are compatible with regulatory functions for this subdomain. Hence it is hypothesized that the N-terminal cap subdomain plays a central role in modulation of Mak enzymatic activity.	9.00821e-23
NZ_CP019229.1\|WP_068751654.1\|1280209_1281409_+\|glycine-C-acetyltransferase	gnl\|CDD\|235893	PRK06939, PRK06939, 2-amino-3-ketobutyrate coenzyme A ligase; Provisional.	0
NZ_CP019229.1\|WP_068751656.1\|1282954_1283755_+\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	4.30616e-92
NZ_CP019229.1\|WP_141680074.1\|1281590_1282565_-\|hypothetical-protein	gnl\|CDD\|227645	COG5340, COG5340, Predicted transcriptional regulator [Transcription].	1.62277e-07
NZ_CP019229.1\|WP_068751662.1\|1289442_1290462_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.3742e-58
NZ_CP019229.1\|WP_141680073.1\|1278152_1279283_-\|hypothetical-protein	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	2.533e-41
NZ_CP019229.1\|WP_068751648.1\|1271348_1273919_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP019229.1\|WP_068751651.1\|1277831_1278113_-\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	7.42908e-38
NZ_CP019229.1\|WP_068751760.1\|1274107_1276270_+\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|131508	TIGR02455, trehalose_synthase_putative, trehalose synthase, Pseudomonas stutzeri type. Trehalose synthase catalyzes a one-step conversion of maltose to trehalose. This is an alternative to the OtsAB and TreYZ pathways. This family includes a characterized example from Pseudomonas stutzeri plus very closely related sequences from other Pseudomonads. Cutoff scores are set to find a more distantly related sequence from Desulfovibrio vulgaris, likely to be functionally equivalent, between trusted and noise limits. [Energy metabolism, Biosynthesis and degradation of polysaccharides, Cellular processes, Adaptations to atypical conditions].	0

>NZ_CP019229.1|WP_141680074.1|1281590_1282565_-|hypothetical-protein
MLSTTGPGGGRRWHSPSSNGSVNAQWTAKQLLDLGLSPADLRARAKAGALVRLRRGHYAIGSEASPEAEHLRLMRATALDVAQSSVFSHTSAAVLHGLPVDETTLGVATMIRTTPGHGNGSPQLRVRNTSLLGEHITVVDGFSVTTLERTLCDLARLSPLEWGVAAVDAGLRRGADPAEIRRILALHPRLQGVHVAKRVMAFADPRSESAAESLSRVQMRRWGVPSPHLQFEVIDADGVVVARTDFGWPELGLVGEVDGKAKYGRLLKPGQSAEDVVMREKRREQEIRRAGYWIVRWGWAEILDGRKMATIIEDGLRNALPRAS
>NZ_CP019229.1|WP_068751654.1|1280209_1281409_+|glycine-C-acetyltransferase
MAFLDHIRGELAQLRADGLYKTEAPLTTAQAAHVGTPSGEVINLCANNYLGLANSPVLIDAAKKAYDRWGFGMASVRFICGTQTLHQDLEARLTGFLRSGPEGHDGWDTILYSSCFDANGGLFETLFGAEDAIISDELNHASIIDGVRLSKAARYRYRNRDMADLRAQLEASRGARHRVIATDGVFSMDGFVAPLDEICALADEYDALVMVDDSHAVGFVGETGSGTPERFGVIDRVDILTGTLGKALGGASGGYTCARSEVVELLRQRSRPYLFSNSLAPSIVAATIACLDLLETSSALLERLAENTAYFRRRMVEEGFEIPESDHPIVPVMLGDAVLAGRIADEVLARGVYVRAFSFPVVPRGAARIRTQMSAGLSRADLDAAIAAFVAARAAVGSS
>NZ_CP019229.1|WP_068751653.1|1279173_1280202_+|L-threonine-3-dehydrogenase
MLALAKTRPGPGLELIELPRPTPSPNEVLIRVLRTGICGTDLHIDSWDGWAAQVVRTPLVLGHEFCGEIVELGSSVTGLEVGQFVSGEGHYVCGRCRACLAGRRHLCSNTRGIGYHVDGAFCEYFAMPAGNVWVHHTPVDPDVAAIFDPFGNAVHAALQFPALAEDVLVSGAGPIGIMAALVAKFQGARNVVITDLGDERLELARSVGLANTVNVSRENLADVYERFDMHEGFDIGLEMSGSGAALTSMIEHMTHGGRIALLGTPTKPLEVDFATIIFNMLTIQGVTGRQMFETWYAMSALLRSGLDISGVITHRFPASSFREAFDVAAGGHAGKVILTWDE
>NZ_CP019229.1|WP_141680073.1|1278152_1279283_-|hypothetical-protein
MPVRRTRIRTSFGLGVGRGSSMSSSPGPGRVFASANMAPIVADAAAGERCGRGIARLVASPTTTRRGGRTMGPVVRTVTFNTGFDDHFLVDGVTWGGVEKARAFESQPSGKGVFVARRTVACGVPAHAYYLIGEREQAHHVGAVEAAGVVVHPVAVPGRTRHNLTLMMEDRVAAHMVSPGYQLASAAPAETLLRMVVDDARAGDVVTLNGSIPAALPPEALAESVRALAERGARVVSDNQGPYLAAAVGTGVLAAVKPNNEEVTALGDAPDLAGYLWVLAEAGVGLPVITRGADGVAFLDYGEVRLGSCPVAHPRLSVGAGDAFVAGLATGILEDRGALDTVAWASACAAAHVAGADDAAFRAAAERALELFAVRG
>NZ_CP019229.1|WP_068751651.1|1277831_1278113_-|DUF2277-domain-containing-protein
MCRNIRPLNNFEPPATPDEVHAAALQYVRKVAGTTKPSQANEEAFTRAVEAVAAITTDLLDHLVTTAPPKDREAERLKAQARAAKRYGVEVAS
>NZ_CP019229.1|WP_068751650.1|1277265_1277835_-|hypothetical-protein
MSGAAEVHVGATLTPSKMELLAGWLPRQPWFDGDPEQLSRAAFFRFVDPAGAVGLDCMVVTTSGDYYFVPVTWRSAPLDGGDLIGTLDHSELGLRYCYDAQTDPVFVAEATRVIREGDTQADIRDVHGDELPLTMTVQGTGVVAGEGGRLEIMRLLTRAAPTPEDVIGSLVSRWTDDAGPRHDVVAVLR
>NZ_CP019229.1|WP_068751649.1|1276309_1277269_+|L-lactate-dehydrogenase
MSEARNREGAKLAIVGAGAVGSSLAYAALIRGVARHVVLHDINGAKVRAEALDLAHGGQFLPEAVVEGSDDVDITRGADVVVVTAGAKQKPGQTRMDLAGSTVSLMEKVIPPLVERSPDATFLMVTNPVDVTTQAALKISGLPTNRLFGSGTVLDSSRLRQLIATTCDVAVGNVHAYVCGEHGDTETPLWSTATIGGVPLTEWERTTGRLGAAERDEIAHRVVNAAYEVIEGKGATNYAIGLAATRIIESILRDERRVLPVSRMLDGWHGMSGVCMAVPTVVGRDGAGTQLEPPLSADELQRLRTSAEHIRSMAVGLGF
>NZ_CP019229.1|WP_068751760.1|1274107_1276270_+|maltose-alpha-D-glucosyltransferase
MPEISFDEARFAARPARLRPRARRRQVDESPITPPFEPSGANRAYVEWLEEQSMLHDAEKVSRQLAGKHLMWSNPYAHPDPRAAVQRASVWYTAYPLSHITTPGQSFLSSLGATELWDAFSAVGIDAVHTGPVKLAGGLDGWDLTPSVDGHFDRMSMAIDPLFGTEDEFRDMCETAARHNGTIIDDIVPGHTGKGADFRLAELNYRDYPGIYHMIDIPESAWHLLPDVPEGRDSVNLTAEAELALADEGYIIGALQRVIFYEPGVKETNWSVTPPIRDYKGTLRRWVYLHYFKEGQPTINWLDPTCAGMRLVMGDALHSLLDLGSGGLRLDANGFLGVERSFDRSPAWSEGHPLSQAANQLIGSMVRKVGGFTFQELNLAIDDIQRTSAVGPDLSYDFITRPAAQFSLATGDTEFLRLVLREAMDIGVDQASLVHAMQNHDELTYELVHFAAAHRDDIYTLGGVDYRGHELAEHIQQTMRDLLTGPAAPYNSVFTQNGIASTTASIITASLGVTDLDTLTDADIRRIASAHLLLCMYNAWQPGVFALSGWDLVGALPLERDAVKSLISTGDTRWIERGAYDILGVAPEAKKSPSGMPRARTLYGPLPEQLKKDTSFASRLAAILKVRKRNGLATGRLLDVPEVGHRALLVLVNELEIGAVQITALNFGGDRIEARVQSDFLPAGRVFDLSTRRKVGTVDDLGGFTVDLPAFGGLAMIIRD
>NZ_CP019229.1|WP_068751648.1|1271348_1273919_-|ATP-dependent-chaperone-ClpB
MNTEKLTTKSRDAVTAAVRQALTHGNPNTEPVHLLHGLLLTPDNTVGALLTAAGADPAQVDAAADAAIGRLPSTSGSSVSQPALSGPFARVLASAETLADSLGDDFVATEHLLIGLAMVPSDAKTILDRAGVTAEALKERFEELRGGKRVTSAESEGGESALDKYSIDLTERARSGKLDPVIGRDSEIRRVVQVLARRTKNNPVLIGEPGVGKTAVVEGLAQRLVAGDVPDSLKNRRLVSLDLASMVAGAKYRGEFEERLKAVLNEIRDAEGQIVTFIDELHTVVGAGASGEGAMDAGNMLKPMLARGELRMIGATTLDEYRERIEKDPALERRFQQVYVGEPSVDDTVAILRGLRERYEAHHKVRITDSALVAAASLSDRYITSRQLPDKAIDLVDEAASRLRMEIDSSPEEIDMLRRDVDRMTMQAFHLEKEDDEASRERLAALRAELADAQEKLRGLEARWESEKSGLNRVGDLKERIDQLRVEADRAQREGDLTRASQILYGDIPAAERELAEAEASEDTTTQMVSEEVGAPDIAEVVGAWTGIPVGRLLQGESEKLLHMEERIGERLIGQRAAVKAVSDAVRRSRAGISDPNRPTGSFLFLGPTGVGKTELAKALADFLFDDETALVRIDMSEYSEKHSVARLVGAPPGYIGYEEGGQLTEAVRRRPYSVVLLDEVEKAHPDLFNILLQVLDDGRLTDGQGRTVDFRNTLLILTSNLGSQFMADQHMEPGEKRNAVMGVVRQAFRPEFLNRLDDVVLFDALTTEELGQIVDIQIAKLNRRLESRRISIDVSAAAKQWLGEVGFDPVYGARPLRRLVQTTIEDQLARGLLAGEIHDGQTVRFDRVGDGIAQV
>NZ_CP019229.1|WP_068751647.1|1270662_1271289_+|DUF1707-domain-containing-protein
MANEDMRIGDHERDEAITLLQEHMSAGRLTTDEFNERMSRALEARTWRDLGVLFTDLPGRRPMPPDVPTPAVPAPGMGWVAPAPTYGASPDTPEVRQHGGKPWYSQWWILMVAILVTTMSSGRLGFLLPAVAIWIWVIAPALDRERQRRRPAVSAPPRPLTFYEREELLDEIRAGRPISAVKRYRELTGADLYTAKMTVDALRREIGR
>NZ_CP019229.1|WP_068751656.1|1282954_1283755_+|hydroxyethylthiazole-kinase
MTVSAILSAVRASTPLVHCMTNTVVPEVTANVLLAAGAAPAMIDLPEEAAIFATVASALLINVGNGLSEQHEGMRRAAAAADGAGTPWVLDPVAVGALPVRTQLARDLLAHRPTAIRGNASEILGLAGASGGGRGVDATDEVDAAIATAHRLSADTGAVVAISGPVDVIVSAGRTTRVTGGDPLMPLVIGTGCALGATVAAALGATRDTHAPHDAVVAAHALFGAAGLAAAELASHPGSFRTAWLDALHALTPDEVAALVTVEDEP
>NZ_CP019229.1|WP_068751657.1|1283751_1284432_+|thiamine-phosphate-synthase
MSQASPGLADAVDWRLYVVTDTALSGGPDRVPYIVEQAALGGAGVVQVRDKHLPDADFLALTRACRGAARRAEDVTGRPVALVVNDRLDVAEELGLHFHQGQDDGDIRQARRRLGTDLLIGLSISSLVELEAELADQTADVLGLSPLWATPTKTDAAPALGPDGAVRLIDATSGRAKTVAIGGINAATAPDAIATGVDGICVVSAIATAPDPRAAAAHLLALWRTR
>NZ_CP019229.1|WP_068751658.1|1284428_1285280_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MTTPKIVLSIAGSDPSGGAGIQADLKTFTALGVYGAAALAGLTVQNTQGVRAARPVDPDFVAAQIHAVFDDLPVAATKLGMLSNAEVASAVADVLEARRDDAGLIVLDPVMIATSGDALLTDDAVEVVRTRLVPLADVVTPNVPEAAVLLGEAPVSDDNGLIRQARALVAAGARAVLAKGGHLTGAEMTDVYAHGDTFALLTGPRIDTRNTHGTGCTLSSAIAAVAARRGDTRATGVRLESVEEARDYLMRALNSGSTWRLSRTPDQGHGPVDHLVGRAEVGL
>NZ_CP019229.1|WP_078920426.1|1285282_1285963_+|hypothetical-protein
MDWTPGDFSARAWDATAAIRDRIDRLPLLTELADGTLEPHRFVEYLGQDDFYLRGYTRALATLASRAPTSAAAAFWARSAGEAVEAEVLMHDALLADDRLRDLPRPAVASPTTRAYVNSLLAATAFEPYPVGVAAVLPCYWVYADVGATLAGRAAALSPHPYAGWVAAYADPAFQDVTRQAIGWLDDAATAADEDTRARMLTAFVDATHYEELFWARSYDLEAWQA
>NZ_CP019229.1|WP_068751660.1|1286045_1288604_+|glycogen/starch/alpha-glucan-phosphorylase
MPDIAQPGRTLPADESPNTDTRTYGPASTPTHPLATAPVGTPPFSVDGFVREFLHELNTNQGVTLSRSSVNDQYLALASTVKNYLMARWLETNRKTREAKVKTIGYLSAEYLLGRQLGNALLATDLNDIARQGLELCGLDLPTLRAQEVEPGLGNGGLGRLAACFIDSMATMDVPSIGYGIRYEYGIFRQTFVDGRQVEQPDTWLALGSPWEFPHPEAAVRVDFGGHTETYVDDDGRERCRWIPAWNVLGVPYNYMVPGYLNGRVNTLRLWSAQATKAFDLQIFNAGDYAQAVRAQTFAENISKVLYPEDSTPQGKELRLQQQYFFVACSLRDFLDNELEEGFDLHHLSERIIFQLNDTHPVIAVPELMRILMDEKGFEWEEAWEVTKSCFAYTCHTLLPEALEVWSTELLGRLLPRHLEIIFGINERFLKEVRAAFPGDEMRARRMSMIAEYPEQGVRMAYLATVAGTKVNGVAELHSQLLRDKVLPDFSQLWPDKFTNVTNGVTPRRFVRMANPKLSELITDAIGSNWVTDLERLKELEPYADDPEFQARFSEIKAWNKKRLTDLLRQRDGIDLPSGHLLDVMVKRLHEYKRQSLKLLHIVSLYERVLSGTLAVEDLTPRTVVFGAKAAPGYRMAKDTIHLINKVAKVINADERLEGRLKVAFPANYNVTLAEKLIPAADLSEQISLAGMEASGTGNMKFALNGALTIGTDDGANVEIRRLVGDKHFFLFGMSEPEVAELGAKGYTPGSYYESNPQLKAALDLILSGEFSEGDRHMFDSVVYNLLHQDRFMALADFQSYIDAQARVEAKYADEAAWTRSAILNVARTGYFSSDRSMRDYLQRIWHTTPMI
>NZ_CP019229.1|WP_068751661.1|1288655_1289450_-|ABC-transporter-ATP-binding-protein
MGELIARSVTLGYGDRVVARDLDVEVPAGRITSIVGPNGCGKSTLLRGFSRLLAPSTGQILLDGDDVATLSARELARRLGLLPQSPITPEAMTVAELVGLGRHPHRAMLGGWSRSDQDAVDEALEMTRTTDLAGRRVDQLSGGQRQRVWIATVLAQRTATLLLDEPISFLDIARAVEVLDLVVDLNRQRGTTVVMVLHDLNLAARYSDRLIAMRDGAIVAAGAPSDVVTEAMVHDVFGVPSRVVPDPVSGTPLVVPIGRHHRRH
>NZ_CP019229.1|WP_068751662.1|1289442_1290462_-|iron-ABC-transporter-permease
MTAAVLRAATARRRRLVLAAAAAATVALFVARALLGDYQIAAPDAVRILLGADLGPASFLFLETKLPTALVALAAGLALGGSGGAFQSMLRNPLASPDVMGVTLGASAAAVTGLVVAGLTGAQVTAAAFAGGLAVALGIFVLSGGAHSASNRIILIGLGLAFALQAVIHWVLIRGSVYQARDAMRWLSGSLNAMTWDGVSRLWLAVAVGLPLLLLLGRPLRLIEVGDDLAGGLGIRVPRVRLAVLLVVVLLTASATSVAGPIAFVGLLAGPIARRLNAGRSSLPLAALVGAAVVLGADLLGDARWPWGPLPVGIITGLLGAPMLVALLLRSTSEEDIHG
>NZ_CP019229.1|WP_068751663.1|1290458_1291433_-|iron-ABC-transporter-permease
MTVPRAAGGAIAVGGLAAGVLASFAIGAVSVPVGDVVGFLTGADPATAAILAARVDRTLVGVVCGAALALSGAVLQGVTRNPLADPGLLGINAGAALAVAVGVVTGIGASQGTVVALALLGAGAAAAFVALLSRGRPDPVLLVLLGAAVTAACLSAVSAVTIRNQAALEVMRFWQVGSIGGRGLPLLLPSLPVLIMGAVLTVWAGSTLNTLAVGDDLATALGTRIGRTRALLGTGAVLLAAGSVAVVGPIGFVGLVVPHIVRLLMGPDYRVVIAGSVLLGPVLLLTADIIGRVVMPPAEISAGLVVLLLGAPVLVALVRRSVHA
>NZ_CP019229.1|WP_068751664.1|1291429_1292479_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MSLSLRVAGAALAALALTACSTGPATPTPDAASSTAPAASSAPATDAFPVTVTHALGEAVIEAEPTRIATVGWTDHETLVSLGVVPVGAVEITWGGNAQGSTDWFDAAVAELGGEQPTRYDDSAGAPIEEIVALEPDLILATNSGLTQEEYDTLSRVAPVVAYPEAPWSTSWQDSLELVGRAVGRSELAAEVEAETTALLQQAGAEYPEIAGTSAAWLWFAAADYSKFGVYTATDARPRFLDAVGFETPAIVTELSGGAPGQFSVDVSAERAAEFDADVIVFYTDDSVKLADIQAAPLIQDLPALKSGAFVAADDPTLALPLSSPTPLSIPIAVEKFVPLLAEAAAKVQ
>NZ_CP019229.1|WP_078919786.1|1292508_1293351_-|siderophore-interacting-protein
MSIATQAEQARSRTARRRASSAMAATPEPSGQLLVEAEVLAVAAPAAAVRRVTLGAAEFVGLPTAGADEFLGLLMPPTGQGLVLPDPDRVDIRAAVAELPEHARPALRWYTVRRHDDVAGTIDVDIVTHGTSGPGSAWALTVRPGDRVGVRQCGALFLPGDSDRICFVVDETAAPGLAAIMERHDLGPDCRIIVETPDLAHLTPLPWHPGLTVLTRHDRSPGEVARAALADADATAFDYFYLCGESDLAASCRRLLVSERGVARRQVLFSGYWKLGQARV

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Crispr_ID: NZ_CP019229_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_4

1698860-1699024

Orphan

Consensus_repeat	Method
CCGACGCCACCCCGCTCGCTGAGGTCGCGCCCGACGGCGCAGCCGTCCGGGC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP019229_4

>merge|NZ_CP019229|4|1698860-1699024|PILER-CR
CCCGCTCGCTGAGGTCGCGCCCGACAGCACCCCGCTCGCAGCGGTCGCGCCCGACGGCACCCCGCTCGCTGAGGTCGCGCCCGACGGCGCAGCCGTCCGGGCGAGTCTCGAAGCCGACGCCACCCCGCTCGCTGAGGTCGCGCCCGACGGCGCAGCCGTCCGGGC

>NZ_CP019229|4|1|1698860-1699024|PILER-CR
CCCGCTCGCTGAGGTCGCGCCCGACAGCACCCCGCTCGCAGCGGTCGCGCCC	GACGGCACCCCGCTCGCTGAGGTCG
CGCCCGACGGCGCAGCCGTCCGGGCGAGTCTCGAAGCCGACGCCACCCCGCT	CGCTGAGGTCG
CGCCCGACGGCGCAGCCGTCCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068749584.1\|1706542_1707199_-\|LysR-family-transcriptional-regulator-substrate-binding-protein	unknown	unknown	gnl\|CDD\|176102
NZ_CP019229.1\|WP_068749589.1\|1701743_1702853_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP019229.1\|WP_078920443.1\|1700545_1701739_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP019229.1\|WP_078919891.1\|1688404_1689670_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP019229.1\|WP_078919887.1\|1682556_1683477_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP019229.1\|WP_153302388.1\|1706097_1706259_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_068749583.1\|1707234_1707594_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_078919894.1\|1692046_1694839_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_078919890.1\|1687139_1688294_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380539
NZ_CP019229.1\|WP_078919893.1\|1691656_1691998_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_078919897.1\|1708953_1710678_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP019229.1\|WP_068749588.1\|1703027_1704713_+\|family-10-glycosylhydrolase	unknown	unknown	gnl\|CDD\|224563
NZ_CP019229.1\|WP_141679968.1\|1706261_1706447_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|139376
NZ_CP019229.1\|WP_068749581.1\|1710668_1711319_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP019229.1\|WP_078919895.1\|1695121_1697167_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226459
NZ_CP019229.1\|WP_078919888.1\|1683473_1684547_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP019229.1\|WP_078919892.1\|1689848_1691609_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366032
NZ_CP019229.1\|WP_068749587.1\|1704859_1706011_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|130850
NZ_CP019229.1\|WP_078920442.1\|1685538_1687017_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP019229.1\|WP_078919889.1\|1684551_1685535_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068749589.1\|1701743_1702853_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	6.45957e-64
NZ_CP019229.1\|WP_078920443.1\|1700545_1701739_+\|hypothetical-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.00508e-41
NZ_CP019229.1\|WP_078919891.1\|1688404_1689670_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.18294e-57
NZ_CP019229.1\|WP_068749588.1\|1703027_1704713_+\|family-10-glycosylhydrolase	gnl\|CDD\|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	1.01849e-58
NZ_CP019229.1\|WP_078919887.1\|1682556_1683477_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.45232e-35
NZ_CP019229.1\|WP_078919890.1\|1687139_1688294_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380539	cd06316, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	2.29736e-142
NZ_CP019229.1\|WP_078919892.1\|1689848_1691609_+\|hypothetical-protein	gnl\|CDD\|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	9.60227e-66
NZ_CP019229.1\|WP_078919897.1\|1708953_1710678_+\|hypothetical-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.03639e-34
NZ_CP019229.1\|WP_141679968.1\|1706261_1706447_+\|hypothetical-protein	gnl\|CDD\|139376	PRK13150, PRK13150, cytochrome c maturation protein CcmE.	0.00563712
NZ_CP019229.1\|WP_068749581.1\|1710668_1711319_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.08249e-33
NZ_CP019229.1\|WP_078920442.1\|1685538_1687017_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP019229.1\|WP_078919888.1\|1683473_1684547_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	9.78983e-71
NZ_CP019229.1\|WP_068749584.1\|1706542_1707199_-\|LysR-family-transcriptional-regulator-substrate-binding-protein	gnl\|CDD\|176102	cd05466, PBP2_LTTR_substrate, The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily. This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.22853e-19
NZ_CP019229.1\|WP_068749587.1\|1704859_1706011_+\|hypothetical-protein	gnl\|CDD\|130850	TIGR01790, Uncharacterized_carotenoid_cyclase_DR_0801, lycopene cyclase family protein. This family includes lycopene beta and epsilion cyclases (which form beta and delta carotene, respectively) from bacteria and plants as well as the plant capsanthin/capsorubin and neoxanthin cyclases which appear to have evolved from the plant lycopene cyclases. The plant lycopene epsilon cyclases also transform neurosporene to alpha zeacarotene.	9.52318e-43
NZ_CP019229.1\|WP_078919895.1\|1695121_1697167_+\|AAA-family-ATPase	gnl\|CDD\|226459	COG3950, COG3950, Predicted ATP-binding protein involved in virulence [General function prediction only].	1.05842e-14
NZ_CP019229.1\|WP_078919889.1\|1684551_1685535_-\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	2.01948e-77

>NZ_CP019229.1|WP_078919895.1|1695121_1697167_+|AAA-family-ATPase
MRLRRPAQPDVLGAAAERLTEETARAWRQKRSRGPELDPVLHHPEILDSLLRMTNGTCAYCERALEAEGPDAAVVAHHRPTWGAVGTDGVIALTAYWWLTYEWDNLYPACADCVRSRGTRFPVDGPRAAARQPLDAELPLLLDPLDDDPDEHLRYQPDGTVTALTDRGRATIDILALNRDFLVKARLAALGAPGPAFAALHRQLDAHAAAAPDGAAPGAGTPDAATPPAPPPRPQGPDLPPMAGAEPGAPAYDLNVAMAAPQRGNYYQATQWIERVVIRNFRPVRDLEIDLARSTSDRGPWTVLLGENGCGKSSVLHAIALTLMGGQQRRQLGIDARRYLRDGARKGLVEVYLSGRQEPLRLEWAKGEQDFHGPEPVPALLLGYGATRLLPRTPSPLDDNRVVRVDNLFDPVAPLTDPTTWLLSLDEDTYDDVASGIHEMLALDHDAELIRHRDRVVLKQGRTRSDIGTLSDGYQSMVVMACDILRSTMRLWTQSALAEGIVLIDEIGAHLHPRWRLRIVTAMRNLMPRIQFIVTTHDPLCLRGIVDGEVVVMRRNSEGDIVSLSDLPPVTGMRVDQLLTSEHFGLGSTDDPEVAELWESYYRLMGLKHPTAEQAERLGRVRARLDELEQFGTTERERLLLTSAAGYIAQRRESGDAAAPTSAEVNAKLADLWRQYLPGGD
>NZ_CP019229.1|WP_078919894.1|1692046_1694839_-|hypothetical-protein
MTRSDHSQPRSRAGGRLSQLWATLLLALSLAASVVPGATADPLATSTETDPSTVVVTMSSTASSARTGYSVPITATATLGGNPAPAGSVEFYLSTDGVSFTRHSTVPTSTGTATARIDVPVAPMGEVYFRATYVAPLGSWVKDATSDVFVMPVDQTPTMWLNRSSSVYGANALVTVTVAYFQNPPSVYLDGRFASSCPRTGTCSFGVSTTPAGPHTVVVSDGVTTLTAPYTVVKASTAVSMFCANPSMYTGEAVTPCTATVTGAFLYYEPVEVEYVDNVAVGTAKATAHYPGDDNHEPSIAYGTFAIEMPTAVTVTCGPGPFVYTGSPVTPCSATATGSWQLPPRDVPVTYSGNLNAGTATASASFVGLSGSADFVITKAASTTTVTCPASAIYTGLPLTPCSAEASGVGMTAVPRTPDYTGNVDVGTAAASASWPGDLNHTGSSGTATFAITKAASTVAVSCPTSPSTYTGTAQTPCTAKASGPGMADVPLTLTYSGNVNAGTATASASWAGSANLAGSSGSATFQIAKAPSATTVTCTAGPHLFDGDAQTPCSAVAARVGGPTVPVTVDYSGNVDAGTASASAAWAGDANHLGSSDSATFTINRAPVTMTAGGYGGEFDGAAHPVSACVVTGAYVGSLSCANDPSTVGPAVGSGVTTPLMVFGAEKASNFEVSAVAGQWEVTAVPLAVSVRAVPAVEWPGDGNYAGGVEVLVGTQTGAGIPNDATMRVRLSGVGTGATATLACDATFDGRLGSHVCSAATVDLPRDVYAVVAESVTGNAAGVGYGSLTVYDPDARRSAAVSGTVSWGDGASGSIGLSASSVRKNVLGGVTLVRTWDDGDAHTAVLSSTELTGFSVGRQRIDGGQCRVATLTGVADYTLDGATGAGHSVTVTVTDCAGVAGDRIEVTGPGVFGPVSPSLVDGGVLIVNS
>NZ_CP019229.1|WP_078919893.1|1691656_1691998_+|hypothetical-protein
MQYAFSAKLDIDGRDVRIVPVGEKKYRISIPEYIFIGHSNEDFRLVAENNGVLSFITPENDPVEMINSILNADAQADYIADNEEILREQATYFYSSIITGIDPEIDITYDFSQ
>NZ_CP019229.1|WP_078919892.1|1689848_1691609_+|hypothetical-protein
MQFGTERELIRRDERPAQALVNPRVLARRFSAPGRTDGTFREDHPLSTNRLKTRILRTAGLGAAAALALSGLAAPAHSSPDDGLIPPLKDVYSDYFKVGNIYSGEGTYAEDSPNWAQVERHYNIMTAENIMKPDQLLPNDNINTDTGEWTFNFGPADYFVDESRERGIDVHGHVLVWHSQSPSKIYGLESADPRAQAKANMERYIKEVLTHFKGRIVSWDVVNEAFVDGLDTFDPATQNWEDFLRGNPSDYSYSGWYDAYTTDMDEAAGERPGDFIYDAFVFARKYGPEAKLEYNDFNVFQSEGKAKAILAMATELNERYAAEYPEDERQLIEGIGLQSHNYINQTPAFACSDLTRLPKLVDEDAAEWQPGACSDHASVERSLQLITEAGFTASVSELDLQVWEAWNAEPQGERGTYYDLDDPAAADLFHKEGFTYWVGKIDNRMELEAIQAQRFAEYFAVYKKYSQDLDRVTFWGLTDALNWRRNHNPQLFNADFSQKLAAPAVADPEGLLGVKKPITDASGLFDAIGEAEALGLQGKQYTGKSIGALRAIIGRATATAQSGQTQAEINAAHEEVVEAAAGLELK
>NZ_CP019229.1|WP_078919891.1|1688404_1689670_+|ROK-family-protein
MDPNLLPHTVTEQVRTLATVLALVREDRARTRPEIGRQSGLARNVVADRVDQLIHAGLLAEGELGASTGGRAPRELRFRADAGYVLVAEIGATVCGVGIADLSGQLVSTLEAPVDVKVGPVPTLEYVSSLLDGLLGDISTESIWGVGIGLPGPVEWMTGRPVAPPIMPGWDGFDVRGFFASRYGCAVWVDNDVNAMATGEARAGVAQGHQDVIYVKVGTGIGSGLFSRGQIHRGAQGAAGDIGHLALGARKNVVCRCGNTGCLEALAGGGALVRDALAAAEDPRSTYLRREHQSGRPLNVNVIVEAALFGDPVALEMLSSSAMAVGEALAGMVNIFNPSMIVIGGSVGRSLDMYLATIRRAVLDRSLPLATRSLQIVTSPLGDRAGLIGLAFTVIDELLSPEALSTWLERGTPTGLTQLTA
>NZ_CP019229.1|WP_078919890.1|1687139_1688294_-|substrate-binding-domain-containing-protein
MLRFIRPLAVAAALAMTLSGCSAESTSTSTTNSEVDAQVDAALKELEGTVLSKGPHGEDPATAETAELTPEEIDEVKSMGATAAIVMHYGGNDWSTAQVDGLQAEFANLGIEVVAVTDANFKPDKQVSDIETVLSKNPDIIVSIPTDPVATASAYKKAADAGVKLVFMDNSPQGLEAGTDYVSVVSADNYGNGVVSAHLMAKSLGGAGKIGVIYHEADFFVTKQRYEGFTATIADEYPEVEVVAEQGIAGPDFAGDAQAAANAMLSRYPDLAGIWAVWDVPAEGVMAAARASGRDDLKIATQDLGKNVAIALAKDELIVGLGAQRPYDQGVTEARLAAGALLGKTAAPYVALAALPVEHDNVLDAWKQVYQADAPDDLAGAFEE
>NZ_CP019229.1|WP_078920442.1|1685538_1687017_-|sugar-ABC-transporter-ATP-binding-protein
MRGINKSFYGIPVLVDVDLEIRRGEVHALAGGNGAGKSTLMKILQGVYSRDSGDIEIEGKRVALNSIHDAKAAGIGMVFQEFSLVPSLTVAQNMYLTVEPTGRTGLISDREARRMAAQVFSEMDVAVDPSATVRNLPTALWQLTEIAKALSQDARVLIMDEPTASLARHEVEALFELIGRLKARGISIIYISHRMDEVYRIADRITILRDGKRLLTEPLSAVTPEEIVEGIVGRRVDGALEYQERRKATDADILLEAVDLRAGRRVNGISFQLRRGEIIGLAGLMGSGRTELARCLFGIDRPESGEIRIQGEVVDIQSPGAAVEAGLALIPEDRREQGLVLDHSVRENILLPLLDRIRSGPLLNRGAGKRLAAELIDRFSVKVADAEKPVRTLSGGNQQKVVIAKWLGTEPKVLIMDEPTAGVDIGTKSEIVGIIRELADSGQGIIVISSEYPELLAVSDRVLIMRDGQIVKELERSEIPDEESLQLAVLGV
>NZ_CP019229.1|WP_078919889.1|1684551_1685535_-|ABC-transporter-permease
MSNPTTTPPTSGAAPSWTSRLAGLDWRRYIIYIAFVVVFLLFAVTLADSGFLSQNNLLNIFRQTATITVIAVGMTFVISCAEIDLSVGSIAGLSSVVSAMTIATYGLVPGIIAGLAVGAIVGATNGALVSLLGIPSFLVTLGMLGIAFGIAQWITDSAPQPILNDTFNAIFGGGDIGPIPGLMIWMALAVTIGAIVLNRTKFGRQVLATGGNRAAAEFTGVNTKRIKFSVLLISGLAASVAGMLYAGRLQSGRFQWGSGDELSAIAAVILGGTSLFGGSGAIIGTFMGALLIGLINNGLILAGLESSQQQVIRGVIIILAVALARKK
>NZ_CP019229.1|WP_078919888.1|1683473_1684547_-|Gfo/Idh/MocA-family-oxidoreductase
MTIQTVRSGVIGAGFIGGVHSYAVRAAGGRLTRIADATPEASQDAAARLGAEGPAASPEELIASDDVDVVHICTPNSTHAALAELAISHGKAVICEKPLATTAADAERVTRAAREAGVVTAVPFVYRFHPNVRETRARIAAGEAGRLWMLHGSYLQDWLSRSDDTNWRVDPAVGGVSRAFGDIGVHWCDLMEFVTGQRIVNLSARTARAYGERTGTEDGAVVMFETDGGASGSLVVSQVSPGRKNRLWFSFDGTDASFSFDQESPEQLWVGGREENRLLLRNPDTQHPQAGRLSRLPAGHPQGYQDAFTAFVSDVYSAVRGGNPDGLPTFEDGLRAARVTEAVVASSAHSTWKELSA
>NZ_CP019229.1|WP_078919887.1|1682556_1683477_-|sugar-phosphate-isomerase/epimerase
MKLGFLTACLPDRSLKEIASWAAGEGFEALEVAAWPALGQRPFTATHITVENFGDEQAESVQDLMSSTGLTISSLAFYDNNLHPDPAERTAINNHVLACIDAAARLGVPTVGTFVGRDWTKPVRENLSEAEEVFKPLVDQAGEKGVKLVIENCVMEGWHPDGYPGNLAYSPELWEWMFSLGLYLNFDPSHLVWMGIDPVTAMTPYVDRIAHAQAKDIQLFPEKRNRYGWPGIAVDREDPWNVGWWRYRVPGLGEVDWRGVVDALYEHGFDGVLSVEHEDPVWGGTEPKIKTGLRIAHRTLRPLMVD
>NZ_CP019229.1|WP_078920443.1|1700545_1701739_+|hypothetical-protein
MSGLDVLAREVADFLAYAAAHRNEVFLVTEIGCGIAGYTPDDVAPLFAGAPGNVALPASFLERLPASDATPGSVPLGADGRVADRAAGVVVASAAGDALGAPYEFGPPLSDEVTPAFGVGTFGHAPGEWTDDTSMAMPILEAIARGDSLRDPEVLAHIVRRWWEWSRDARDVGAQTRAVLAGIEATGPAAVTEDFMRGRARAVHDAAGRSGGNGSLMRTGPVALAYLAQGAERDLVDAAARIAQLTHWEDDNVDAVVLWSLAIRHAVLTGELDPRVGLPFVPEQRRRRWAPLIDDATAPGAHPRDFHAQNGWVVRAFQAALAAVTGAADLRDALERAVRGGADTDTVAAIAGSLAGAVWGASHVPAEWRASLHGWPGYTVDDLSRLTLEALGQGPAA
>NZ_CP019229.1|WP_068749589.1|1701743_1702853_-|YihY/virulence-factor-BrkB-family-protein
MSPDQKFADGSEPESVDQTRDKAATAPHPEDPRKPDSPSDLAKPSWRYALRRALSEFSKDHVTDLAASLTYFAVLSLFPMLLALVSLLGVFGRGEQTVEGINRWIETYAPAELSALLSDTITGLAGQTGAGLALVTGLAGALWAASGYVGAFSRAMNRIYEVEEGRPIWKHKPQMLALTFVLVLLMAVIVFALLLSGDLADTVGAFIGLADTTVLLWNIAKWPVVVALAVLAVALLYYFTPNVRQPRFRWISVGAVVALVVSALAVAAFSVYVANFASYNATYGIIGSVIVMLLGLWIINNVLLFGAEIDAEIERGRQLQGGIEAEETIKLPPRDTRASEKLADKHAALVDRGRELRLEHGRDHSRDEA
>NZ_CP019229.1|WP_068749588.1|1703027_1704713_+|family-10-glycosylhydrolase
MRKIITLAIAALLAVVAFQPNPAAAAPVSQWRSLWVDAFNPGLSSPQQIAQVVADAKAANVNTLLVQSVRRFDCFCTKSTYPRSSTIATPAPFDPLAEVIRQAHAAGLRVHAWFNVGTLWNSTTPPADPAHVYNTHGPSATGANRWLDKRYDGGELSGSNSYVDLANPAAVDYIVAGANSIVRNYDVDGINLDYIRYPDRTGTIAGNDWGYSATSLQRFRAATGRTDTPLPSDQQFSQWRRDQVTNVVRRISQTVAAADTSVVLSVNAISYGDGPSATLSWQASAPYAAVLQDWYGWTKAKLIDAVVLMNYKRQHDAAQAAMFTSWNQFLVRVRNETGRHMISGAALYLNTIPNSVRQAQAVTSLGLGWSGFSYANTSQAAAASTSLTVKTEQRRQTFAALKASVFAAPASVPAMPWKTPVDVYSTPGYHQVNGREWRTTCEPYSQTIRCRTDIWATAVTYTGGRYVKTNTWVFNNLTYLPYMTRAQWGSNPLANDSGGKVFYSGGRQWKTECDTATTGYGGCRSYILSLGVVHAVRNPDGTWRYYRADTWVFNNMVRFKL
>NZ_CP019229.1|WP_068749587.1|1704859_1706011_+|hypothetical-protein
MGGVSASSRFDVAVVGLGPAGRALASRAAAQGLLVLAVDPRPDAVWSPTYGIWADELGDLPPSVIRSRVARPELRAHGVYRLPRDYLVLDNPALQAALPLDGVAVRRERLDDDGVAALRAEARVVVDARGARPDGIVPGDPSPAQTAFGIVVPADDAAPALQGATGLLMDWRTDWAGDEAGETPTFLYAIPLGDGTVLLEETCLAAAPGLPIPELKARLRRRLLARGMAEAAVDHPLEREVVRIPMRGRARPAPAGVLAAGTAGRGGNLVTGYSVAHSMARAGSLAAELAAGRAPRAVDARGPADVFREMGLRALLRLDVAGTLGLFDAFGRLPASAQRDFMSRDSTAPGLARAMWGMFVGMSACDRGRLIAATLGPPSLGQG
>NZ_CP019229.1|WP_153302388.1|1706097_1706259_+|hypothetical-protein
MRRSEQQVAVWVCGTKGVRLAAWSSFGFGLVSLAALAYPLVLSRTAPRATTAR
>NZ_CP019229.1|WP_141679968.1|1706261_1706447_+|hypothetical-protein
MSNSQLLPLASISISLVGLALAVYALRRRDRHWPVWVGLVASGLTVAFWLYFFIANIVTPG
>NZ_CP019229.1|WP_068749584.1|1706542_1707199_-|LysR-family-transcriptional-regulator-substrate-binding-protein
MTTSPSGDRLRVGAVPGVTLTKWRRIWEERFPRVTLDVLEVDEADQRRILAEDAVDMCFVRLPVDQEGLHAIPLYDEVMVAWASKEHPVSVLDEVTLADLAGETVVDAVTAESVDVAAHSGATVLLVPMSIARSHSRRDMAYRLVTDAPPSTVALAWRTDSDNEWVDEFIGVVRGRTVNSSRTARERGDEPAAAKPAPARKAAAKVSRAAPRRRARRR
>NZ_CP019229.1|WP_068749583.1|1707234_1707594_+|hypothetical-protein
MSQTMKPVTAAAKLGIYLPAAPEEFQTTPITRAELDALRADPPAWLTDLRRNGPFPKEVMAQKLGISRSGLVRGGITEALTADQIGELIADPPEWLVRERETHRKVLEEEARLKSEQSR
>NZ_CP019229.1|WP_078919897.1|1708953_1710678_+|hypothetical-protein
MGLRPRDIRPQLVDSLRAALAAVLVAGSAAAGLEAALLAAVPGFHPLTLAYPAAAFVYVAAGALAWWRRPGSLMGALIMLGGLALLVAGVGNTELPGFTEVGAVAGTWILAVIVHLLLAFPGGRLRHRLPRAIVAAAYVNSVVLQLPRALLPAEQGQWWAGAQSAVGTVVMVTVAGVLLYRLLLASPAKRRTLIPLYGYGLAVAGLIPTSTLILRGLLGMDPLQVWMLQMAAIAGVPLAFLAASLLGSFAPTAEAQALAAWLSAGTDRPPVAQALTRALGDPSVRITYWVPERQEFVDTAGERTDVPAPGSPDRDAVHIRSGGDLLGAILFDPRATTARAAQEAAGVVALAIEGERLTAALRASRAALLRSRSRLVEAADAVRTAIARDLHDGLQVRLVLLAVEAQRLANAAAAGADGHRLSTEATTLRHGIDEAAAELRRLARQVMPSALEERGLALAVEDLTDRMPLPTRFDAAAVPEDLPPAVALTAYFAVSEGLTNAVKHGRASTAWVTIERSGADLVVEVADDGAGGAAPRPGSGIGGLRDRVETVGGRLTVTSPQGGGTRLRVEVPCA
>NZ_CP019229.1|WP_068749581.1|1710668_1711319_+|response-regulator-transcription-factor
MRVVIAEDELLLRQGLTLVLEEGGVDVAAGVGDAASLLDAVVDLAPDLVITDIRMPPTFTDEGLRAALRIRQGGVAVVVLSQYVQRRYAIELLGGDGAGVGYLLKQRIADISTFLADLRRVADGGTVLDPEVVGLMLSRAEHTGGPVRRLTRRQREVLALMAEGRSNAGIAAELVLTEKAVVQHTSHIYDALGLPLTADDHRRVLAVIRYLEGSAG

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Crispr_ID: NZ_CP019229_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_5

1731828-1731902

Orphan

Consensus_repeat	Method
GCAGGCATCTGAACGCAGGGCAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019229_5

>merge|NZ_CP019229|5|1731828-1731902|CRISPRCasFinder
GCAGGCATCTGAACGCAGGGCAGGCGACGGAGAGACGCCTGCGCTGTAGGGCAGGCGGCCGGACGTATGGCAGGC

>NZ_CP019229|5|4|1731828-1731902|CRISPRCasFinder
GCAGGCATCTGAACGCAGGGCAGGC	GACGGAGAGACGCCTGCGCTGTAGG
GCAGGCGGCCGGACGTATGGCAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068749558.1\|1743500_1744661_-\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|236089
NZ_CP019229.1\|WP_078920444.1\|1735495_1737493_-\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|235542
NZ_CP019229.1\|WP_068749569.1\|1724366_1725005_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP019229.1\|WP_068749630.1\|1740906_1741431_+\|DUF721-domain-containing-protein	unknown	unknown	gnl\|CDD\|179552
NZ_CP019229.1\|WP_068749571.1\|1722567_1723539_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238861
NZ_CP019229.1\|WP_068749568.1\|1727018_1727906_-\|phosphoribulokinase	unknown	unknown	gnl\|CDD\|237970
NZ_CP019229.1\|WP_078919902.1\|1723606_1724455_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP019229.1\|WP_068749567.1\|1727916_1728987_-\|fructose-1,6-bisphosphatase	unknown	unknown	gnl\|CDD\|238214
NZ_CP019229.1\|WP_068749566.1\|1729009_1730386_-\|ribulose-bisphosphate-carboxylase	unknown	unknown	gnl\|CDD\|184072
NZ_CP019229.1\|WP_068749560.1\|1741437_1742586_-\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NZ_CP019229.1\|WP_068749559.1\|1742594_1743476_-\|decarboxylating-6-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236582
NZ_CP019229.1\|WP_068749563.1\|1737949_1738696_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP019229.1\|WP_078919904.1\|1731957_1732836_-\|DUF3566-domain-containing-protein	unknown	unknown	gnl\|CDD\|378809
NZ_CP019229.1\|WP_068749635.1\|1726196_1727012_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180446
NZ_CP019229.1\|WP_068749573.1\|1720240_1721413_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP019229.1\|WP_141679966.1\|1740236_1740908_-\|DUF541-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NZ_CP019229.1\|WP_078919903.1\|1725119_1726148_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223604
NZ_CP019229.1\|WP_068749572.1\|1721525_1722533_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP019229.1\|WP_153302389.1\|1738699_1740088_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP019229.1\|WP_068749565.1\|1732828_1735450_-\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068749558.1\|1743500_1744661_-\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|236089	PRK07761, PRK07761, DNA polymerase III subunit beta; Validated.	0
NZ_CP019229.1\|WP_078920444.1\|1735495_1737493_-\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|235542	PRK05644, gyrB, DNA gyrase subunit B; Validated.	0
NZ_CP019229.1\|WP_068749569.1\|1724366_1725005_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.8619e-09
NZ_CP019229.1\|WP_068749630.1\|1740906_1741431_+\|DUF721-domain-containing-protein	gnl\|CDD\|179552	PRK03195, PRK03195, DUF721 family protein.	8.69614e-36
NZ_CP019229.1\|WP_068749571.1\|1722567_1723539_-\|hypothetical-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	2.87649e-48
NZ_CP019229.1\|WP_068749568.1\|1727018_1727906_-\|phosphoribulokinase	gnl\|CDD\|237970	PRK15453, PRK15453, phosphoribulokinase; Provisional.	0
NZ_CP019229.1\|WP_078919902.1\|1723606_1724455_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.0571e-15
NZ_CP019229.1\|WP_068749567.1\|1727916_1728987_-\|fructose-1,6-bisphosphatase	gnl\|CDD\|238214	cd00354, FBPase, Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-biphosphatases that play a role in pentose phosphate pathway (Calvin cycle).	1.40566e-92
NZ_CP019229.1\|WP_068749566.1\|1729009_1730386_-\|ribulose-bisphosphate-carboxylase	gnl\|CDD\|184072	PRK13475, PRK13475, ribulose-bisphosphate carboxylase.	0
NZ_CP019229.1\|WP_068749560.1\|1741437_1742586_-\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	7.11913e-134
NZ_CP019229.1\|WP_068749559.1\|1742594_1743476_-\|decarboxylating-6-phosphogluconate-dehydrogenase	gnl\|CDD\|236582	PRK09599, PRK09599, NADP-dependent phosphogluconate dehydrogenase.	1.2116e-170
NZ_CP019229.1\|WP_068749563.1\|1737949_1738696_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	4.52826e-14
NZ_CP019229.1\|WP_078919904.1\|1731957_1732836_-\|DUF3566-domain-containing-protein	gnl\|CDD\|378809	pfam12089, DUF3566, Transmembrane domain of unknown function (DUF3566). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.	8.89869e-49
NZ_CP019229.1\|WP_068749635.1\|1726196_1727012_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180446	PRK06180, PRK06180, short chain dehydrogenase; Provisional.	1.95338e-122
NZ_CP019229.1\|WP_068749573.1\|1720240_1721413_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	7.55109e-55
NZ_CP019229.1\|WP_141679966.1\|1740236_1740908_-\|DUF541-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	2.92945e-12
NZ_CP019229.1\|WP_078919903.1\|1725119_1726148_+\|hypothetical-protein	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	3.50581e-26
NZ_CP019229.1\|WP_068749572.1\|1721525_1722533_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.25062e-81
NZ_CP019229.1\|WP_153302389.1\|1738699_1740088_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	3.18361e-37
NZ_CP019229.1\|WP_068749565.1\|1732828_1735450_-\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0

>NZ_CP019229.1|WP_068749566.1|1729009_1730386_-|ribulose-bisphosphate-carboxylase
MDQSARYTDLSLREDDLIAGGKHILCAYAMRPKSGSFLEAAAHFAAESSTGTNVDVSTTDDFTRGVDAIVYHADEATEEVRIAYPLDLFDRNMIDGRMMMVSFLTLTIGNNQGMGDIEYAKMFDFYVPRAAISLFDGPAMGIADLWRVLGRPVTDGGYIAGTIIKPKLGLRPEPFARAAYEFWLGGDFIKNDEPQGNQVFAPMKQTIPLVYDAMKRAMDDTGEAKLFSANITADDHAEMIARGEFILETFGPDADKVAFLVDGYVGGPGAVTTARRYFARQYLHFHRAGHGAVTSPSSKRGYTAYVLAKMARLQGASGIHVGTMGYGKMEGARDDRAIAYICERDQYQGPAFHQEWHGMRPTTPIVSGGMNALRLPGFFANLGHANIINTAGGGAYGHLDGAAAGGRSLRQAHECWAAGADPVEWATGHREFARAFESFPADADALYPGWRQALGVDR
>NZ_CP019229.1|WP_068749567.1|1727916_1728987_-|fructose-1,6-bisphosphatase
MSDQTFTQYLLDVQDAARGPQRPPGHDYAHILSAVAVSMKLTASLVSRGPLALSGASRSAGEPGTLQRGLRRLATRTLLERVAGIGRLAAVSIAGDPSIHQISAGLDARYLLLAEALHGSGGLYENQTVGLAFSILERLGGGPCGEADFMQPETRQVCAGIGLYGPSTMLVLTTGHGVDGFTLDRDVGNFVLTHPQMTIPTSSGSFAINPSEARHWPAPTKRYVDECLRGSDGPRGRDFTMRWNASAVIGAFRVLVNGGLFMAPDTGRRVGLWGMPLMHNAAPLAFLAEQAGGAATTGGERILDLVPLSLTQRIPIFFGAVEEVRRIERYVDEHARGLDEGQSYPLFHHRTLFIEP
>NZ_CP019229.1|WP_068749568.1|1727018_1727906_-|phosphoribulokinase
MSDTHPVVAITGSSGAGTTTVTDTFAQIFARESITSAIVHGDSFHRYDRDEMKRVYEEAGENAPSHFGPEANLFGELEDLFAEYGRSGTGKVRQYVHDDEEAQLYGRPPGTFTPWLDLPAGTDLLYYEGLHGAVRTDAVDVARHVDLRIGVVPIINLEWIQKLHRDRSTRGYSTEAVTDTILRRMPDYVHYICPQFSNTHINFQRVPVVDTSNPFIAGWIPTLDESMVVIRFADPRGIDFPYLLSMIDGSFMSRANSIVVPGGKMHLAMQLIFTPLIWWLVESSRKARAREGART
>NZ_CP019229.1|WP_068749635.1|1726196_1727012_+|SDR-family-NAD(P)-dependent-oxidoreductase
MATWLITGCSSGLGRTLAEAARDAGHQVVATARDRATLDDLAGDRVLTLTLDVTDPAQIEAAVAEAETAFGGVDVLVNNAGYGYRAAVEEGADDDVRRLFDTHFYGSVALIKAVLPGMRSRRSGAIVNLSSIGATMTPVGSGYYAAVKAAVEGMSGSLRGELAPLGISVTVVEPGVFATDFAGRSLTQSATVIDDYAGTAGTRRIENVVKKPAPGDPVKAAAAILRAVEADEPPAFLLLGSDALDTYRAVMRARLDEVDRWEDLSRSTDFS
>NZ_CP019229.1|WP_078919903.1|1725119_1726148_+|hypothetical-protein
MSELVALIAFVACAAAIFVAGGRLSRYGERIGELSGWGSAWVGLILMASVTSLPELMVGISSSAIVGSADLAVGDVLGSCAINLLILASLDMLVPERKRLLSLASPSHALAAGLGIVLLATVGVAMLSGDAMPLTPWIGASSLLFLGLYVGSVRLIFRHSRSAPDPGVQAPLDVHLTARDPATAHLTLPQAVGRYAAVAAVVVGAALILPPAAEQIARMSGLEESFVGTVFLAVSTSLPELAVSLAAVRMGAVDLAVGNLLGSNLFNILILTVDELVYTKGLLLADASPTQVSTVLTTIAMSAVVIIGLTYQAGAAKRFVLAGDAALMLAVYGGNAALLLML
>NZ_CP019229.1|WP_068749569.1|1724366_1725005_-|TetR/AcrR-family-transcriptional-regulator
MEPGRRQRRHDQTRDEIVALAIEIMAGQGVAGLSLGEVARRLGVRTPSLYTYVESKGALYDELFRRGWQACLDEMRARRGALEPIDGHTDTVARVLAITDAFVRWALANPELSQLMLTRPVPQWQPTPEAFAPSLAVVALSRDELAALCANELLHPLTDVDELVQNLATATTGAVVRHLANEPDVAYADGVAVGHLPALVRALVLAHLPERT
>NZ_CP019229.1|WP_078919902.1|1723606_1724455_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MSPMPTASPSATSRHSSGLSCSRTSPKGPDMRAIDIPLPGPGDGLRVARAQHLRLIDEVNELAPEQWAAVTECPAWTVRDMVGHIASVARFQGNPLLFLVDAQIGRFRYRGRSTLDAANEVGIDRHRSLSTAELLATLRRRAESDRDTPGWLRRFPAKDEALPTYTTIGSFVDTILTRDVWLHRHDIARAVGAATQPDPTDAEVVEQVVRDLGLAWTGPAVHLRLTGPEGGAWDLGEGAGPEVELPAVEFMRHLSGRTAAPGLLDGVPAEVRGPLAGARVAF
>NZ_CP019229.1|WP_068749571.1|1722567_1723539_-|hypothetical-protein
MIRRGVRGIAAALTTVVVAMSITIAGAEAAPKNPKPTPTAEPTPSPSPTASPTPAPQPMYVALGDSYAAGTGAGSYLQDSSGCYRSLKGYPGLVATEKGYALNLQACSGAVTADVLDKQLTSSLTDASYVTITIGGNDVGFASIMTTCMGSNEAACLSAVQTAVEVTKTDLPSRLDAVFSAVKTEAPSAAIVATNYPHLLSPVKPDCSWLTAFTKNEVTAINSGADTLSDTISAAAGRAGIRFADVREPFTGHAVCDSSSWINNASLATYQSFHPNATGYASGYKPTVAGVLGGTATGTAATVTTGGTTSSDTTRGMVKLPKD
>NZ_CP019229.1|WP_068749572.1|1721525_1722533_+|LacI-family-transcriptional-regulator
MSPRRRPVRPTIYDVAREAGVSKSLVSLVLNGSSLVAEPKRQAVQDAIAKLGYRRSQAASALAADRTRTVGLVIDDFQNPSFVELLRGLRAAVGPQGFHVAIREHYRDGDTFVNAIDGFLDSQVDALVVAAEPGRDLPTLGVPTVLEGTRLHRIDDADTVESDQRHGVDQLMEHLRSAGHRRIGHVTGAGGAAAVRLQAYLEAVEAQGEAARFAGESNETNEDGGYAGAVELLRRHPDVTAVFAANDTMALGTRAALREAGREVPRDVALIGYDNSHLARSRFLDLTTVDSHAYDAGVACGEAILRRLAEPDLPPASVVVPSTLVVRSSSATVVR
>NZ_CP019229.1|WP_068749573.1|1720240_1721413_-|Gfo/Idh/MocA-family-oxidoreductase
MTIGIAVIGAGMAGKSHAAAYRVAPTLYRPTLPDLRYVSICDVNAEIGEATARRYGYERSDTDWRAIAADPDIHVVSVVIANSLHLEVVRGLLEAGKHVLCEKPLADTLESAREMARLAREASSIARIGLTYVRQPGIAAIRNWIQDGTLGTVLHLSARYWCDYACNPKGQMSWRYKGPMGSGALADVGSHLTYLSEFLCGDMTAVSGGAFTTAITERPLPLGAVVGHGQVDVSSETEPVENDDYATFTAKFGATTASLEASRVAAGYPNGLNFEVFCVNGAASFHQDTPSQVRLYLHDDQPGTNGYRTVNLGSDHPYVAGGMAIDVSGVGFGQNEGFAFQARAFLEEVAGIPESESLPRNASFDDGVHNMEILAAVAESAADNGKTVTL
>NZ_CP019229.1|WP_078919904.1|1731957_1732836_-|DUF3566-domain-containing-protein
MSENSPRWPSASGAGGLDFSRNRPSPSEQPDSNGRPAEWQPLETPPAPVRAGYAVPGDDGAAASVTTPSRAADDPDATDEERPDADATGESGSEQTRTLPAFAGRAARAAQDWAAKARNAVVITPGGPSAGSAATTGAASGAAAGLVTGAAVAEHHEPTPAEGAAPHRTVRRTRKARLRLARIDPWSVMKTSFLFSIAFGVMLVAATFMVWSVLAGSGALESTNQLINTLIGDEDTAFNIGDFLSMSRVLGFATVVAAVDVVILTAVATLFAFLYNLAATVMGGLEVTLAED
>NZ_CP019229.1|WP_068749565.1|1732828_1735450_-|DNA-gyrase-subunit-A
MADDGTLVPPSLGRVDPIDLQVEIQRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMWDGGYRPDRGWNKCSRVVGEVMGLYHPHGDTAIYDTLVRLAQPWAMRHPLVSGQGNFGSQGNDKAAAMRYTECKMAPLAVEMVREIEQNTVDFKPNYDNREEEPVVLPARFPNLLVNGSTGIAVGMATNIPTHNLREVNDAVQWALEHPEATREELLDAAMHRIQGPDFPGGGLIVGRGGIEEAYRTGRGSVTMRAVIDMEEDNKGRQMLVVTELPYMVNPDALAQRIADLVNAGKLTGIADIRDDTSARTGQRLVIVLKRDAQPRVVMNNLYKHTALQDTFGCNMLAIVDDVPRTLRLDQFISLWIKHQLDVIRRRTQYQLDDAEKQAHIYRGLVKALDALDEVIALIRRSPSTEDAREGLMDLLGIDQVQATAILDMQLRRLAALERQKIIDHLSQLEARIEDLKDILANEPRQRQIIADELQEIVDKYGDDRRTRIVAADGDFSEEDFIPDEDVVVTITHGGYAKRTRADQYRVQKRGGKGVRGASLRADDEVEHLFTTTNHQWLLFFTNFGRVYRAKVWQLPESGRDAKGGHVAGLLSFLPDEKIAQVLTIRSYEDAEYLLLATKHGLVKKTDLKAYDSPRQAGVIAVNFREESDELIGASLVSSTDDVLLISRKGQAIRFPADDAQLRPMGRATSGVTGMKFRSGDELLSMAVLRADEDQSDRFVFTVTDGGFAKRTAVDEYRVQGRGGLGIKAMRLNEDRGSLVGGLIVREGDEVLAIKVSGQVTRSAVAGVPVKGRDTMGVKFVGVKGDDAVGAIALYPESEAADAVDADPATFDGDAAEAEPGTVEDSAADQATSEPTTEGVADDE
>NZ_CP019229.1|WP_078920444.1|1735495_1737493_-|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MEGLLDTADNTVSGSYDADQISVLEGLEAVRKRPGMYIGSTGERGLHHLVYEIVDNSVDEALAGYCNSIEIELLDNGGVRVKDDGRGIPVKEHPVEKIPTVTLVLTVLHAGGKFGDGGYKVSGGLHGVGSSVVNALSDKLIVDVRRDGYRWQQTFHLGVPVTELERLEETTETGTTVTFYPSQDIFETTRYNYDTLATRFREMAFLNKGLRISLIDLRADHQVATGDEGETDTPYDEFQFDDGLIDYVKYLSAGKDTIHPTVIAVEAHAPEQGMGVEIAMQWNSSYTNSVYTFANTINTHEGGTHEEGFRAALTNTVNRWGESWGLIKKRDDRVSGDDIREGLTAIVSIKVSEPQFEGQTKTKLGNTEAKSFVQRVLNDRLGDWFERNPAEGKDIVRKAQSAAQARIAARKARDMARSRKGLLGGSGLPGKLVDCQSTDPSECEMFIVEGDSAGGSARGGRDPRTQAILPIRGKILNVEKARIDRILANKEVEAIINALGAGMQEDFDLAKLRYHKLILMADADVDGAHIRTLLLTLLFRFMRPLIEAGHVYLAQPPLFRLRWTNAPHELAYSDSERDALRIKGLEEGKKLPQVNPIQRYKGLGEMNADDLWDTTMDPDNRILLQVTLEDAAMADQMFSILMGEDVEQRRTFIQRNARDVRFLDI
>NZ_CP019229.1|WP_068749563.1|1737949_1738696_+|sulfite-exporter-TauE/SafE-family-protein
MEWTWIAAGAAALIIGIAKTSFGGLGSIAVALLALALPTKESTAAALLLLITGDIIGVMRYRRSADWSLLRALLPSVVPGILLGALFINVVDDLVLRRSIGAILLTSVLIQLVMTTLARRRAPDPADAGPPHRALTIGAGVAAGFTTMAANAAGPVMAVYLQLAKVEKMRFLGTSAWFYFIVNVAKTPLTASLGLFTPQVLVTVAWGIPVVLVGTVIGVALIHRVPQRAFDVITLLTSILAAGALLIV
>NZ_CP019229.1|WP_153302389.1|1738699_1740088_-|peptidoglycan-DD-metalloendopeptidase-family-protein
MRLQGLSSVIAAAISAALVGGAVATAQDPQTALEAVPAPVSSAAPSPFLAAAELPSLPMRVAAVDVARNEDRELTFDPFSAPTPEIAPLEGPRIPDPPPPSAPPTISAEPSIGSLGDLVDGDLFAQPVNGRRTSAFGMRFHPVLRRWKLHTGLDFAAPCGTPVGAAAGGRVVATGWAGGNGVQVKIDHGWIGGYRVVTTYNHLSAIGVRVGQVVEALDGIGRVGNTGYSTGCHLHFEVIANGQFTDPEPWLNGKPSRVDLSSVAFFDVPDMPSPLPSATPSVSPSPSASASLSPLLSLSPSGSPSPSASPSPSLSWSPSPSLSPSPSPSVSVSPSPSPVASPAPSPSLTPSPAVSDPSPTPSVIESSPVAAASVASPSTEAASSPAPEPTTPAPAPTTQQPPPPPPPPPPSPTTEAPAPTTEAPDPTTRAPEPPPPTEEPAPEPAPTSEAPPEPTAEPSPTA
>NZ_CP019229.1|WP_141679966.1|1740236_1740908_-|DUF541-domain-containing-protein
MISRVPAAARDTYARGMRITVTGTSTVTLPAECVAVTLTLGFSGADREPVIADTAALADRLRARLAEAVASGAARDLTLSGLRTWTATPVDERGRPAPAQHTAEVRGSVVLDDLTVAGPLLGELATVPGVQIGWLDWRLRDATVADLQPRALADAFGRARRRAEWIAAAAGAGTLEVVSITDGGAPGTFARSAMRMAEAAPSFTLDPGEVDLSATLTVDFDAR
>NZ_CP019229.1|WP_068749630.1|1740906_1741431_+|DUF721-domain-containing-protein
MSEEAHDPTGLELASEIARAAVESAAYGPTLPEPAPPKPVRRRRVFQEQRSGAHPDERDPQRVGDVLESVIQARGWQRRIGLSTVLRRWPELVGEANAQHSKPVDYADGVLIVDCDSTAWASAMRYAASQIVATLNRKLGDRTVLRVEFRGPKPPSWKKGTRSVKGLGPRDTYG
>NZ_CP019229.1|WP_068749560.1|1741437_1742586_-|DNA-replication/repair-protein-RecF
MFVTELALVDFRNYTEASLTLSSGVTVFVGANGQGKTNLVEAVEYLSTMSSHRVSATAPLIRAGAETAVVRAKVQAGREDERVISLELEIANGRSNVARLNRAPVARARDIVGALRTVVFSPVDLGIVRGDPSDRRAWLDSLIVTRWPRMAGVRQDYDKVLKQRNALLKGMAGRSFVPTGGDEDVTLTVWNEQLAALGAELLHARLDTLADVLPHAQRAYETIAPVNNRIDATYKTGLDLGAMPDDDVRAELQRRLLEQMERLRRDEVSRGVTLVGPQRDDVELSIGALPAKGYASHGESWSLALALRLGGFSLVRDDGVQPVLVLDDVFAELDVSRRERLAAAVADAEQVLITAAVGADVPDFPAERRFRVEAGTVSGPDA
>NZ_CP019229.1|WP_068749559.1|1742594_1743476_-|decarboxylating-6-phosphogluconate-dehydrogenase
MRIGLIGLGKMGGNMRERLRRGGVEVVGLDHNPAISDAADEADLIAQLGDGPRVIWLMVPIHAVDALIETLKPLLSPGDIVIDGGNSKWTHDARHAAYLADAGVRFLDCGVSGGVWGLENGYALMVGGPADAVEIAMPVFEALKPEGEFGFVHAGDHGAGHFAKMVHNGVEYGLMQAYAEGWELLETAEIVKNVPAVLESWREGTVIRSWLLDLMTHALDADPHLDGIEGYAEDSGEGRWTVNAAVDLAVPVPTIAASLFARFVSRQEDSPAMKMVAAMRQQFGGHAVAPAKD
>NZ_CP019229.1|WP_068749558.1|1743500_1744661_-|DNA-polymerase-III-subunit-beta
MKIRVERDALADAVAWVARSLPTRPTAPILAGMLLQADAKGLTMSSFDSTTSAKVSLPATVTDEGTVLVSGRLLAEIARSLPNKPVDLVADHSKVELTCGQARFTLQTLPVDEYPTLPDMPTQTGEVDATVFEKAVGQVFVAAGRDELLSVFTGVKMEINGESLSLLATDRYRMALKELTWRPSSPSVEGAVLVPGKVLADTAKSMTSGDTVTISLSTTEAEGEGLAGFVGESARGTREATTRLLSQAFPKVRHLMDVDATVSVRVNTGDLLAAVKRVSLVAERNTPLRMRINDDHIALEAATGDQAQASEALEAQVEVVGDEQSITDAGFNPHYLLDALTALDAPYAHFSFTLPGKPCLIMGLATVDGDPLVDYRHVIMLMRLPN

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Crispr_ID: NZ_CP019229_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_6

1855627-1855758

Orphan

Consensus_repeat	Method
CGCACCGGGCGCGACCTCAGCGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP019229_6

>merge|NZ_CP019229|6|1855627-1855758|CRISPRCasFinder
CGCACCGGGCGCGACCTCAGCGAGCGGGGTGGCGTCGGCTTCGAGACTCGCCCGGGTGCTGCGCACCGGGCGCGACCTCAGCGAACGGTTCAGGCGCGACCTCAGCGAGCGGTGCAGGCGCGACCTCAGCGA

>NZ_CP019229|6|5|1855627-1855758|CRISPRCasFinder
CGCACCGGGCGCGACCTCAGCGA	GCGGGGTGGCGTCGGCTTCGAGACTCGCCCGGGTGCTG
CGCACCGGGCGCGACCTCAGCGA	ACGGTTCAGGCGCGACCTCAGCGAG
CGGTGCAGGCGCGACCTCAGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068751816.1\|1848697_1849579_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP019229.1\|WP_068751823.1\|1855776_1856763_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381312
NZ_CP019229.1\|WP_078919934.1\|1859485_1860742_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP019229.1\|WP_078919933.1\|1855043_1855571_-\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473
NZ_CP019229.1\|WP_068751831.1\|1861857_1862832_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381313
NZ_CP019229.1\|WP_068751828.1\|1858512_1859367_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NZ_CP019229.1\|WP_068751829.1\|1860766_1861102_-\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|376440
NZ_CP019229.1\|WP_068751814.1\|1846460_1847144_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP019229.1\|WP_068751824.1\|1856804_1857017_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226181
NZ_CP019229.1\|WP_068751813.1\|1846160_1846343_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_068751818.1\|1851059_1851590_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP019229.1\|WP_068751825.1\|1857017_1857503_-\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP019229.1\|WP_068751830.1\|1861094_1861841_-\|NAD-dependent-deacetylase	unknown	unknown	gnl\|CDD\|234777
NZ_CP019229.1\|WP_068751817.1\|1849582_1850941_+\|GntP-family-transporter	unknown	unknown	gnl\|CDD\|182094
NZ_CP019229.1\|WP_068751821.1\|1854123_1854903_+\|DUF3883-domain-containing-protein	unknown	unknown	gnl\|CDD\|379021
NZ_CP019229.1\|WP_068751827.1\|1857987_1858440_+\|methylglyoxal-synthase	unknown	unknown	gnl\|CDD\|179969
NZ_CP019229.1\|WP_141680086.1\|1857588_1857876_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019229.1\|WP_068751815.1\|1847237_1848671_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215463
NZ_CP019229.1\|WP_068751820.1\|1853508_1854003_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP019229.1\|WP_078920450.1\|1852910_1853459_-\|NAD(+)--rifampin-ADP-ribosyltransferase	unknown	unknown	gnl\|CDD\|378815

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068751816.1\|1848697_1849579_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	1.45475e-66
NZ_CP019229.1\|WP_068751823.1\|1855776_1856763_-\|aldo/keto-reductase	gnl\|CDD\|381312	cd19086, AKR_AKR11C1, AKR11C family of aldo-keto reductase (AKR). Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.	6.37243e-104
NZ_CP019229.1\|WP_078919934.1\|1859485_1860742_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.20499e-25
NZ_CP019229.1\|WP_078919933.1\|1855043_1855571_-\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	8.26178e-13
NZ_CP019229.1\|WP_068751831.1\|1861857_1862832_-\|aldo/keto-reductase	gnl\|CDD\|381313	cd19087, AKR_AKR12A1_B1_C1, AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR). Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.	1.9723e-162
NZ_CP019229.1\|WP_068751828.1\|1858512_1859367_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	5.49201e-113
NZ_CP019229.1\|WP_068751829.1\|1860766_1861102_-\|MGMT-family-protein	gnl\|CDD\|376440	pfam01035, DNA_binding_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain. This domain is a 3 helical bundle.	2.6435e-14
NZ_CP019229.1\|WP_068751814.1\|1846460_1847144_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	3.72014e-50
NZ_CP019229.1\|WP_068751824.1\|1856804_1857017_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	6.07604e-28
NZ_CP019229.1\|WP_068751818.1\|1851059_1851590_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.94046e-11
NZ_CP019229.1\|WP_068751825.1\|1857017_1857503_-\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	9.73061e-19
NZ_CP019229.1\|WP_068751830.1\|1861094_1861841_-\|NAD-dependent-deacetylase	gnl\|CDD\|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	1.92548e-76
NZ_CP019229.1\|WP_068751817.1\|1849582_1850941_+\|GntP-family-transporter	gnl\|CDD\|182094	PRK09821, PRK09821, putative transporter; Provisional.	0
NZ_CP019229.1\|WP_068751821.1\|1854123_1854903_+\|DUF3883-domain-containing-protein	gnl\|CDD\|379021	pfam13020, DUF3883, Domain of unknown function (DUF3883). This is a domain is uncharacterized. It is found on restriction endonucleases.	9.98343e-25
NZ_CP019229.1\|WP_068751827.1\|1857987_1858440_+\|methylglyoxal-synthase	gnl\|CDD\|179969	PRK05234, mgsA, methylglyoxal synthase; Validated.	5.38133e-83
NZ_CP019229.1\|WP_068751815.1\|1847237_1848671_+\|hypothetical-protein	gnl\|CDD\|215463	PLN02858, PLN02858, fructose-bisphosphate aldolase.	8.34585e-93
NZ_CP019229.1\|WP_068751820.1\|1853508_1854003_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.43568e-24
NZ_CP019229.1\|WP_078920450.1\|1852910_1853459_-\|NAD(+)--rifampin-ADP-ribosyltransferase	gnl\|CDD\|378815	pfam12120, Arr-ms, Rifampin ADP-ribosyl transferase. This protein is found in bacteria. Proteins in this family are typically between 136 to 150 amino acids in length. The opportunistic pathogen Mycobacterium smegmatis is resistant to rifampin because of the presence of a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). Arr-ms is a small enzyme whose activity thus renders rifamycin antibiotics ineffective.	3.42427e-54

>NZ_CP019229.1|WP_078919933.1|1855043_1855571_-|TM2-domain-containing-protein
MTDACATLCPTPRTPAAPTKDRSMTQYPQDPQQPHGQPSGDQPQYGQPTSQPQFGQQPYGAPYQGQQPYGAPYQGQQPYGAPYQGQPPYAPGGQVGQKSKIVAGILGILLGGLGIHNFYLGFTKKALAQLLITVLSVGFLSWVSAIWGLVEGILILVSKYGEQWHRDAAGFELAD
>NZ_CP019229.1|WP_068751821.1|1854123_1854903_+|DUF3883-domain-containing-protein
MLELELNGQRYSKAHHASGLMAQLEGRSRKSIDFKHCNISAVMLQLGYPYIRGYKPLANYQGLLFDVVEDRLRGNRSVDQAVEAAVGRPAAEVSIPAMDIVWVDPPPAAKRPAETWRPTFRHLVRDYLAQEARNRSLGQAGELFVAEFEARRLDAAGKKSLAARVEHVAASMGDGLGFDVLSFDLDGRERLIEVKTTSFGELTPFFVSRNELARSEADRDQYHLYRVFDFRDQPRLFGLQGAISEQCSLDPVSYLARVA
>NZ_CP019229.1|WP_068751820.1|1853508_1854003_+|GNAT-family-N-acetyltransferase
MAATLRPYRDTDAEPTWQVFHAAVRVTAAADYTPEQVEAWSPDEVDLEAWGRRRAAAWTVVAVQGERVVGFSDLTDDGVLDMLFVHPDVGGQGVARLLVGAVLEEARRRGVSRVVTHASRTARPAFERLGFVVGRENVENWTRGVRVPNYDMAVVFAAKPGNRA
>NZ_CP019229.1|WP_078920450.1|1852910_1853459_-|NAD(+)--rifampin-ADP-ribosyltransferase
MPRQRTSQRAIRSTRWQTPGYPATRTKLRSGEDPGAHTPVTFESCSHVEGPFYHGTKSAVEAGTELVPGYGSNFHAGRASNNIYFSALVETAVWGAELATALAGSAERGHVYVVEPTGPFEDDPNVTNKRFPGNPTQSYRTRHPLRVVAEVKEWEGHEPAVLNGMLDHLAQLREQGLDVIED
>NZ_CP019229.1|WP_068751818.1|1851059_1851590_+|GNAT-family-N-acetyltransferase
MDLSFRRAEPHDTSAAQAAYRRIIDHLADTVDFPHWHTENHPTPAEVAGWIEAGELHLAVDVDDAIAGVVVLNHDAVDAYREAGWAIEAEPHEVLIVHALGVVPDHLGLGVARFLVDASIRVARERRCRAVRLDTYVENLPARRLYARYGFTDLGCHTVRYDGTELDQFHLFEYVL
>NZ_CP019229.1|WP_068751817.1|1849582_1850941_+|GntP-family-transporter
MGAGTLLGIALGAIILLLILVIRIKMSAFVALLLVAFGTALATGIALTDIVPTMTAGMGNTLASVMIVVGLGAMLGRLIEVSGGADALAEKFSAVLGPKRVVAAVTAAAFVLGIPVFFDVGFIILAPIVFGFARVAKINPLALGLPVAGAMLTVHVALPPHPGPVAAAGITGADVGMMLLWGLPIAAVTAVIGFFAAKMFKPEKYELLESPATKSAAIHDEAVDGPKRVLGAGTVIALILLPILQIMVGTVGNMTLEEGTFGRGLVGMLGASPIALLTAVVVGYLVVGHNQRWSLGKRGSVLESALPDVAVIVFVTGAGGVFANVLVTSGIGKAFSEALISINMPIILAGFLISLALRASQGSATVAILTAAGLLAQPIMDAGYSGTQMTLVTLAIAFGGLGLSHINDSGFWIVTKYLGLSVKDGLRTWTVLSTIFGLTGFLLTWGVFALVS
>NZ_CP019229.1|WP_068751816.1|1848697_1849579_+|NAD(P)-dependent-oxidoreductase
MNIAVLGLGAMGLPMATWLAQTFSVTAFDIADARVQLAANAGITCRPSARDAVDGADIVLVAVRNQAQLEELLYGAAGIVPALRRGAAIILTSTVGIQAVEAVAARLTDDGIGLADAPVSGGPARAGKGDLLVTVGAYPAVYEHCRPVLEAMASNLVWVGETPGKGQSMKTVNQLLCGVHIAAAAEALALAGELGLDQTKALEALMSGAAASFMLGDRGPRAIQAYDGEAAEVKSRLDIFVKDMGIVTSAAKGVGMPVPVAAAAEQLYLQGLANGQGAMDDSSVITLVTPKKG
>NZ_CP019229.1|WP_068751815.1|1847237_1848671_+|hypothetical-protein
MTVELSDLLSNHAAAVPVSADDVATARRDAGDHTIYVVLDDDPTGTQSVADLPVLTAWEADDFRWAFATGKPAIYVMTNSRSLAPADAERVNREVVAAALEAAGDSPVAFVSRSDSTLRGHFPLEPRTIAEEIRAATGHGVDGIVVVPAFGDAGRITVDGVHYAGSRDAGFTPVGETEFARDATFGYRSSRLADWVEEKTQGEILADDVILIDLTTLRTDRAHTVALLRSASDARVIVVDIVEEEDLRLLALALIDAEAAGSRFVYRVGPPFCRARIGQAVRTPVTVDEIRSSRGDHAVATGGLIVVGSHVDLTTRQLTHLREQQNPLELEIEVAQVTDPAVRDTHVQDVATRAAAALNDGNVVVRTSRTLVTGADGHESLHISRQVSAAVVEVVQRVLAANPPRFVVAKGGITSSDVATKGLGFRHATVIGPMLPGIVSLWSGQDGPAAGIPYVVFAGNVGAADSLAAVVDTLNHA
>NZ_CP019229.1|WP_068751814.1|1846460_1847144_+|FadR-family-transcriptional-regulator
MSRRGLVDEAIQGILDRVVDGGFPAGSALPPEADLAALLEVSRPTMREAVRSLSDRGVLRVVHGRGTFVAPQTEWRDLPTLIGVLARTTPSRDLGLQLIQVRRMLEVGAAGLAAEHRTDDDVARMRDLLDRYDAAGSDVDEVAALDIAFHEAILAASGNPFLAAIMQPLAEALAASRRTTAAREDVRSRAQEHHRRIADRIAAGDAPGAKDAMRAHMTQTHDDIAAL
>NZ_CP019229.1|WP_068751813.1|1846160_1846343_+|hypothetical-protein
MHEQQLRVPAGSTVADLSKAPLPTESTLRKRMSLPLQVIRFFVFNARIMRMVLKGHSQDH
>NZ_CP019229.1|WP_068751823.1|1855776_1856763_-|aldo/keto-reductase
MQKSTLGRTGREVGVVGQGCWQFGGDWGDVSDDASMGVLHAAADAGVTFFDTADVYGDGHSEELVGRFLKERPSDDIMVATKLGRRAAPHTPEQFTRENLRAWTERSRRLLGVDTIDLTQLHCPPTPVYSDGAVYDALDEMVEEGWLRAYGVSVETVDEALTALERPGVASIQIILNVFRRKPLERVLPAAAAAGVGIIARVPLASGLLTGKFTEDTTFAPEDHRTYNRHGEAFDQGETFSGVPYGVGVQAAREFASIVPEGVTPAQFALRWIIDQPGVSVVIPGASRPEQAAANAAAGSLPSLTDDQLAACERIYDEYIREYVHDRW
>NZ_CP019229.1|WP_068751824.1|1856804_1857017_-|helix-turn-helix-transcriptional-regulator
MAIVVDIDVLLAKRRMSVGSLAEQIGITPANLAVLKNGRAKAVRFTTLEALCEALDCQPGDLLRWEPDEA
>NZ_CP019229.1|WP_068751825.1|1857017_1857503_-|DUF2975-domain-containing-protein
MGKASITVLRVIIAIALLGSLAVQVVIVPLLWLDMDGGRPDITIPILAIVVLGVGTLQVTAVCIWMLLTRVRRGTVFSPSSFRYVDTIIGAIATASVLTFGLAVVGAYANRTTPGDEIAPGLVGMICGVSLVIAGVALVVYVMRQLLAQAVAFRSELDEVI
>NZ_CP019229.1|WP_141680086.1|1857588_1857876_+|hypothetical-protein
MRFLGFEAAARHLSQRRIATSTAGSTWRSPSSRTTFAPHVAIAVGEVREDLEVADVLTGVRMVYGLVVTSSGGGTLSETIGAASRAWFGLAPNAG
>NZ_CP019229.1|WP_068751827.1|1857987_1858440_+|methylglyoxal-synthase
MPGIKHNIALVAHDNKKAELLSWANFNRGTLSHHTLFATGTTGTMLEYELGLPVTRLLSGPVGGDQQIGAMIAEGRIDTLIFFWDPLEPQPHDPDVKALLRIGAVWNVPMACNTATADLLISSPLLDEPWANRPDISPRAWEPDADDEDD
>NZ_CP019229.1|WP_068751828.1|1858512_1859367_+|prolipoprotein-diacylglyceryl-transferase
MPLELPFPNINPVAINLFGLKIHWYAIMYLLAFGLAYLLMRRRLHHEPYRSITKPEPWGATDIEDILLNSIVGVLVGGRLGYTLFYNPGFYLANPLEIVKIWDGGMSFHGGAIGVVLGLAWFGWRKGRPFLQVADFLVPAVPIGLAAGRFGNFINGELWGREASADLPWAMRFPTGGDVLRHPSQLYQMLLEGLLLFVLLWWYARKPRYRGQIAGAFLAGYGFFRFVAEFWREPDAHLGFLSLGLSMGQWLSLPMIVAGVVLWSWARTRAVSDVEAEPVVDATS
>NZ_CP019229.1|WP_078919934.1|1859485_1860742_-|ROK-family-transcriptional-regulator
MQETGQWGAPARRPRRGRGGTMSEMQGPVSGMTQAVMRSSNLALVMRKVADHSGRISRADIAHQLGMTRSTVSRLVDDLIDGGLVAEGTASGTGRGRPAVPLSLRRGTALGLGLQVGVGRLSAVLVDLDGTVEATAETMTDVPKLGLAASVEELQRLSGQVLGSLPEGGHLIGAFAAIPGLLDVRSGRVVRAPNLGWDGESLGAHWTLTHEGGRVPLAAANDATCAAVTVMRSDPDSSFLLLCGDVGIGGALCRDGTLVLGEHGWSGELGHICVDPRGVPCRCGSIGCMETIVSLPALLSASRQPSLEAYRRALTNGDERAEAVLRRTVGALGIGLGAAMNVWDVSTIRLCCYFAELEPWLREPLTRQLMGRVVWGRKAHIDVGALPALPLRPAIGAGLIALGPVVKDPDSFLTRGAA
>NZ_CP019229.1|WP_068751829.1|1860766_1861102_-|MGMT-family-protein
MTDPLEVIERVLRAVEQVPHGHVVSYGDIAALVETSPRRVGAIMGEWGGEVAWWRVTSAAGRLPEPLVPLARKQWQREGIPVDGDHCVISRCRADLTRLAADYADAVEDLS
>NZ_CP019229.1|WP_068751830.1|1861094_1861841_-|NAD-dependent-deacetylase
MAAIQSLDEARRILILSGAGLSTAAGIPDFRGPEGLWTRDPYAELVSTLSWYLRDDDVRKAAWRRRADPAMWAAQPTRAHRAIAALERAGRLRAIVTQNTDGLHQVAGSSPELVHEIHGSARTWRCEMCGRTGPMAEMLERVAAGDEDPRCPVCGGITRATVVLFEEVLDADVLGAAVAAAEDCDAIVAVGTTLGVYPVAGLFPLAVEHGAFGVIVNDAPTAYDDVAHQVVRGRLDDELPALLGVADD
>NZ_CP019229.1|WP_068751831.1|1861857_1862832_-|aldo/keto-reductase
MQYTHLGRSGLLVSRLVLGTMNFGPHTSEEDAHAIMDRALDAGINFFDTANGYGGQGHRGRTEEIIGRWFAKSGRRDEVVLATKCYGSTLDEDKPNYSKLSAVNVRRSAIASLERLQTDHIDLYQMHHVDRATSWDEVWQSMDRLVAAGDIVYVGSSNFAGWHIAAANEAAKARHSLGLVSEQSLYHLGARTVELEVLPAARHYGLGVIPWSPLGGGLLGGVLQKIESGRRADAGMLRRVEENRAQLEAWESFCRDLGEAPGDVALAWLLHQDGVTGPIIGPRTMEQLDSALHALEIELDESALKRLDEIFPGPGGAAPEAYAW

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Crispr_ID: NZ_CP019229_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_7

2030728-2030813

Orphan

Consensus_repeat	Method
AGGCAGGCGTCGGGACGGGGGGCAGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019229_7

>merge|NZ_CP019229|7|2030728-2030813|CRISPRCasFinder
AGGCAGGCGTCGGGACGGGGGGCAGGCGTCGCGACGGGGGGGCAGGCGTCAGGACGGGAGGCAGGCGTCGCGACGGGAGGCAGGCG

>NZ_CP019229|7|6|2030728-2030813|CRISPRCasFinder
AGGCAGGCGTCGGGACGGGGGGCAGGCG	TCGCGACGGGGGGGCAGGCGTCAGGACGGG
AGGCAGGCGTCGCGACGGGAGGCAGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_068751941.1\|2034169_2035105_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP019229.1\|WP_068751934.1\|2024757_2026461_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225942
NZ_CP019229.1\|WP_068752027.1\|2039335_2040064_+\|DUF881-domain-containing-protein	unknown	unknown	gnl\|CDD\|377575
NZ_CP019229.1\|WP_068751945.1\|2038902_2039187_-\|cell-division-protein-CrgA	unknown	unknown	gnl\|CDD\|377706
NZ_CP019229.1\|WP_141680096.1\|2021299_2022922_-\|L-aspartate-oxidase	unknown	unknown	gnl\|CDD\|236102
NZ_CP019229.1\|WP_068751938.1\|2030833_2031856_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP019229.1\|WP_068751943.1\|2036699_2038220_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP019229.1\|WP_068752026.1\|2027315_2028161_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP019229.1\|WP_068751939.1\|2031855_2033265_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|274539
NZ_CP019229.1\|WP_078919970.1\|2022918_2023950_-\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|376787
NZ_CP019229.1\|WP_068751932.1\|2020436_2021303_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|236125
NZ_CP019229.1\|WP_068751936.1\|2028235_2029525_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP019229.1\|WP_068751940.1\|2033261_2034170_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP019229.1\|WP_068751946.1\|2040109_2040748_+\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|181107
NZ_CP019229.1\|WP_068751931.1\|2019489_2020299_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP019229.1\|WP_068751933.1\|2024013_2024730_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|223979
NZ_CP019229.1\|WP_068751935.1\|2026460_2027312_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP019229.1\|WP_078919971.1\|2029521_2030478_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP019229.1\|WP_068751942.1\|2035179_2036493_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_CP019229.1\|WP_141680097.1\|2038261_2038906_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319829

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_068751941.1\|2034169_2035105_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.2689e-73
NZ_CP019229.1\|WP_068751934.1\|2024757_2026461_-\|hypothetical-protein	gnl\|CDD\|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	4.81542e-11
NZ_CP019229.1\|WP_068752027.1\|2039335_2040064_+\|DUF881-domain-containing-protein	gnl\|CDD\|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	1.92589e-50
NZ_CP019229.1\|WP_068751945.1\|2038902_2039187_-\|cell-division-protein-CrgA	gnl\|CDD\|377706	pfam06781, CrgA, Cell division protein CrgA. CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis. CrgA has homologs in other actinomycetes.	3.41056e-25
NZ_CP019229.1\|WP_141680096.1\|2021299_2022922_-\|L-aspartate-oxidase	gnl\|CDD\|236102	PRK07804, PRK07804, L-aspartate oxidase; Provisional.	0
NZ_CP019229.1\|WP_068751938.1\|2030833_2031856_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.45953e-93
NZ_CP019229.1\|WP_068751943.1\|2036699_2038220_-\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP019229.1\|WP_068752026.1\|2027315_2028161_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.58583e-69
NZ_CP019229.1\|WP_068751939.1\|2031855_2033265_-\|beta-glucosidase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP019229.1\|WP_078919970.1\|2022918_2023950_-\|quinolinate-synthase-NadA	gnl\|CDD\|376787	pfam02445, NadA, Quinolinate synthetase A protein. Quinolinate synthetase catalyzes the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid. This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein".	2.20981e-157
NZ_CP019229.1\|WP_068751932.1\|2020436_2021303_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|236125	PRK07896, PRK07896, carboxylating nicotinate-nucleotide diphosphorylase.	2.40304e-122
NZ_CP019229.1\|WP_068751936.1\|2028235_2029525_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.58717e-48
NZ_CP019229.1\|WP_068751940.1\|2033261_2034170_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.53408e-71
NZ_CP019229.1\|WP_068751946.1\|2040109_2040748_+\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	8.86359e-125
NZ_CP019229.1\|WP_068751931.1\|2019489_2020299_-\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	2.83646e-05
NZ_CP019229.1\|WP_068751933.1\|2024013_2024730_+\|NUDIX-domain-containing-protein	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.93046e-14
NZ_CP019229.1\|WP_068751935.1\|2026460_2027312_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.45591e-82
NZ_CP019229.1\|WP_078919971.1\|2029521_2030478_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.76996e-17
NZ_CP019229.1\|WP_068751942.1\|2035179_2036493_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	6.97118e-21
NZ_CP019229.1\|WP_141680097.1\|2038261_2038906_-\|HAD-IA-family-hydrolase	gnl\|CDD\|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.25459e-48

>NZ_CP019229.1|WP_078919971.1|2029521_2030478_-|DMT-family-transporter
MRRSTTATLALLVVTAIWGSTFFIIKDAVNLIDPIDFLAVRFAVGAAIPAAIFWRRLRRLTATQWQIGLALGGLYGLAQIVQTVGLQTTAASVSGFITGTYVVLTPIIMWIAFRARLNARTWAAVGLALVGLAVLSLTGIGGGGVGEALTLVGATLYAVHIVLLDRWSRSMDTMSLAIVQLIGVALTAGFLGLPGGYHVPADPGVWGAIAYTAVVAGIVTMLLQTWAQRHITPTRVALLMTFEPVFASAFAVGFGGEAVTLRLIAGGALILLATLLGITGGQAGPADDVPLIPAPEGADTPPPTTPVINGDRQEGDSL
>NZ_CP019229.1|WP_068751936.1|2028235_2029525_-|extracellular-solute-binding-protein
MTILTRRRVGALAGLAALGIGLTACSGGNASTPTDGDAKVVWSTWGSPEELKMFDRVQDSFKEANPDVELVFQPTPSYSDYHSKLLTQLSSGTAPDVFYVGDDRIASVIRNDVLAPVSSSSLDEGDFAENVLDVARWEGELYALPNDVNPDALWYDKEALKAAGITEDPAELAANDEWTTEKFFEMTGKLADAGLTGAVYWNYWATHDSIMTAGGGQVYDDEGAYVAHTDAKSVAALDEYAARFATGELKLADLLPEGSGEDTLLVTHQLGFLAQGRYTIGTIRGAGVDESLYDIVRWPTPDGKAAPTGVAASYLAVSKDAAENDAAWDFFSFFLSAEGQQLRLEGTGNAVPSIAGTDDIVLADGFPAHAQTMLDMRDLGYSNFATEAAVPDLSNQIAVEFMQPLYEAGSGAQETLDAVAELVEEKTAS
>NZ_CP019229.1|WP_068752026.1|2027315_2028161_-|sugar-ABC-transporter-permease
MAFVAPQALGMLLFTLLPFAAAFLLAFTEWNGFGMPEFIGFDNFADQLTSPLLGRAILNTMVIALVTVPIGLFLAIVAAVVLNKIRGRAFYLVLFFAPVVTSSVAIALIWQQLLRADGVLSGSLTRLFGIAPIDWLGDPILALLAVCLVTIWASLGLNVVIFMAGLQSISPSVMEAAAIDGAGPVARFFKIILPLLSPIVFYQSVVAFISSLQTFDLVFVLVNNAGPDNGTRTIVYHIYDLGFAKSQFGLSSAASIVLLGLTLVITAIQFGAQKKFVHYES
>NZ_CP019229.1|WP_068751935.1|2026460_2027312_-|carbohydrate-ABC-transporter-permease
MTVLTTPRPRSRGSWLKHPLVLAAALLMVAPFLWMLLTSFKGLPQLLTDPLSILPQPWVFTNWADAWNALPFGRAYANSIYITVLVVAGTLLTTSMAAYGFARIPFKGSTVLFWVFLAMQMVPKQVTLVPFYFLMAKIGWVDSHLALIIPAIMVNPFGVFLARQFIASVPVELEEAAMIDGASRWRIYWTIILPAIRPGLGALGIIVALDAWNNFLLPLVLLNSTDLFTVPLLLSQFQGQFGGMNYGIVMAATALSTVPMLIAFVIGQRQIIESLATSGLGGR
>NZ_CP019229.1|WP_068751934.1|2024757_2026461_-|hypothetical-protein
MADLGRDLAHRFDLEGVPYTARYSRLFVRRGAVGLTVYEAAYERPLADSVVVSGLQILDDAGREVPIVRASPAGIEFDGGVRLVVDGGEVLIGGLPESWSVSADDVASPRLRDALGGFAAEGSPFPLVEERGATESIHASRSLRDGTIRTSPEHHLLAPHDQQLAEWLDRCPAVSPAYRDLTRFCWWVLGVNTLRLDALDGLNRAVVPSKIGYVGLWQWDAYFIAIGLRHGDPDLALEQLRIAVAHQGSDGQLPDVVHEQGVLASSDDLPPADLENLRAMASPSLAHSRVPLTKPPLTALAVAKLAEVIGEGVVDEFLPAVLRAQEWWYTHSTRGGRPVYLHPYSSGLDDSPIFDDDAIIASPDLAAYLVLSDGLLAGWLAERGRHDEAAACRGRADATVDSLVATWGQARGFFPALGEDGQPIPAETIGSLMPLLADGLPVHLVDGVLAAIDDPARFATPHALPTVAASDPDYSTERMWRGPVWVNTNWLVAEGLRRQAAVDPSRADRLLDAADRLERDTLALVDAHGPNEYFNPVSGEKPPRATTVFGWSAALAVDLAVSRSRSG
>NZ_CP019229.1|WP_068751933.1|2024013_2024730_+|NUDIX-domain-containing-protein
MAPHTPRDSVGVALYRHEAIGAVLQVRGVDDGAPRLSVLLARRDHEPYAGRYALPSGPVEPEETLEAAVLRHLAQKVDVAGLTHLEQLGTRSDPGRDPAQRTIGTSYLGLVPTVAEPHLPERASWVAVDDLPELAFDHATVVAQAVTRLRAKLSYTNIGFALMPAEFTIAELREVYVAALGHDVAPTNLERVLTRRGQLVPTGEMSAPGTRGGRPARVFRFRDHALVITDPFAVLRPE
>NZ_CP019229.1|WP_078919970.1|2022918_2023950_-|quinolinate-synthase-NadA
MTLLQEPAAGLEAWEWTADEVAAWQTRVHALAAARNAVILAHNYQAPIIQDVAHHVGDSLALSRIAATSDAETIVFAGVHFMAETAKLLSPAKRVLIPDQAAGCSLADTINADQLRAWKAEHPGAVVVSYVNTTAEVKAETDVCCTSSNAVDVVRSIPEDREILFLPDQFLGAHVRRATGRTNIHVWLGECHVHADISPSDLVESVRANPAADLYVHPECGCTTSALWLAESGELPAARTHVLSTGGMLDHARRETSRQVLVATEIGMLHQLRKANPTTDFQPVNPKAACPFMKMTTPEKLEACLGDPSLTRGYEVDVPADVAARARQAVERMVAIGNPGSGE
>NZ_CP019229.1|WP_141680096.1|2021299_2022922_-|L-aspartate-oxidase
MMLPAAAPAWTGRTDVVVVGTGAAGLSALLHLAAAGVDCVAVTRGEVTDSATAWAQGGLAAVWDDGDTLASHLADTLTAGAGLCDAGVVSDLVASAPGAIRRLIGLGARFDRASGGGLDLHLEGGHSARRIIHADGDATGAEIERALWAALSSALAGSRTPVMTRTRLVDVLTDAEGRACGVRLLDADGQVGELLAGAVVLATGGIGQLWPVTSNPLGATGDGVAAALRAGAEVRDLEFMQFHPTVLADAAAGSRGVLVSEAVRGEGAWLVDDAGHRIMAGVHPLLELAPRDVVSAAIMAHLDRTGAPHVWLDATFFGRSTWEGHFPGILALCRGRGVDPVTERIPVHPAAHYACGGVAADLHGRTSVPGLYAVGEVAATGVHGANRLASNSLTEALVAGDRVGALLASGPVGRVGVPVSRAAAGVVEPTAVPAIRAWMQREAFVSRTGPGLAALGAALAAVPLGAGRVDHASLTATNLHAVATIVAAAAAERTESRGAHRRSDFPDTSNTWERRITVRLTEGALELTSAPLAITERTAA
>NZ_CP019229.1|WP_068751932.1|2020436_2021303_-|carboxylating-nicotinate-nucleotide-diphosphorylase
MTTPWNAVDPAEVRRTIEVAVDEDLRLGPDVTTEATVPADAVGVAEVVAREAGVVAGVPVAVEVLRAVASRLGVEASAEEVLDDGSRVAAGDVVLRITGPVRCLLTAERTLLNFLGQLSGVATETAAWVSEVVGTDARIRDTRKTVPGMRALQKYAVVCGGGVNHRMALGDAALIKDNHVAAAGSVAAAFRAVQEHVPGIAIEVECDTVEQVREAVAAGAELVLLDNMTLAETREAVAVCRAAGVRTEASGGLTLDRAAEVAAAGVDYMAVGALTHSAPVLDLGLDLR
>NZ_CP019229.1|WP_068751931.1|2019489_2020299_-|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MFPAGIYSSAQLREEGLTRHRVDRLVRDGSLKRVTSGWYASAEADPAVVSAIKAGGRLGCLSGCALHGLWVPPQSGTHVVFGAGATARRGPGLVLHPDSAPQPRGAVWPVWDCVRHVARRHEPESAVIVAESAINLRLLTVDDARQALAALPVRHARLQERLAPAQSGSETRVRLFFASRHVPVTAQHHIDGVGWVDLLVGDRLIVECDSHAHHGETNYENDRRRDLAARDRGYTTLRLSYQQIWLHWPATQQSLIREIRARRHIRRAR
>NZ_CP019229.1|WP_068751938.1|2030833_2031856_-|LacI-family-transcriptional-regulator
MKGPTMMRPTLEDVARHAGVSRATVSRVVRGDVGVAGETAAKVSAAVAKLGYVPNASARSLATGRSNTLAMVVPEPDGRVFSDPFFGLAVAGINAGMAGTDMQLVMVFASRPDRSGAVVDFLLEGRVAGAIIVSHHRSDGLVAAAAALPMPTVFLGAPLMPPGIERTLYFVDSDNLGGARLAAERMLATGVRHPATVAGPIDMAAALDRLIGWQEVLEAAGLSVAVAHGDYTRESGARAAAELLDADPSIDGIFAASDLMAQGVLDTLRARGLRIGDQVKVIGFDDFEAAAQTHPPLTTVVNPAVELGRQATLMVLNLVEGRDTPSPVILPVELHVRQSG
>NZ_CP019229.1|WP_068751939.1|2031855_2033265_-|beta-glucosidase
MTTYTFPEGFLWGSATAAFQIEGAVHEDGRRDSIWDVFCREPGAVANGDDGTVACDHYHRMPDDVALMSELGLQSYRFSTSWARVRPDDDQFNPAGLDFYSRLVDELLGHGITPWVTLYHWDLPAALQSNGGWTNRDTAYRFVEYAEAMHGALGDRVNIWTTLNEPWCSSFLSYAGGEHAPGHADRREGLHAGHHLLLAHGMATARLRELAPSATLGITTNHTVADPLDPSSPTDVDAARRIDGMFNRFFLDPIFRGAYPADVLEDLAGLGLEDAIQPGDMEIIATPIDVLGVNYYHGEAVTGTPSSDYAPVVGPDGRLRGNPNIGSEWVRSVSRGLPVTDQDWEIQPEGLTRLLVRLHEEYTGPAGIPLYVTENGAAMPDVADEEGFVDDQDRVAFVRDHLVAVHDAISHGADVRGYFVWSFMDNFEWAWGYDKRFGIVRVDYETQHRTPKASALFFRDAASENCVRG
>NZ_CP019229.1|WP_068751940.1|2033261_2034170_-|carbohydrate-ABC-transporter-permease
MSTQMSTPMIEQLAGKGAARAARRKLHGVDKRPGWLTYCALAAVVLISFYPIWFTILLASSNAGEIARNPIPSLIPAGEFLTNVTRVIESDIKFWTALANSIIVSTVTAISVVFFSTLAGYSFAKLRFRGSNGLLVFVIATMAVPTQLSIVPLFILMSELDWVGKLQAVIVPGMVTAFGVFWMTQYLREALPFELIEAARVDGASMIRTFWSVAMPAARPAAAMLALFTFVGSWTNFFWPFIILGSANPTLPVALQLLQASYFKDYSLIMAGVVVATLPLVILFAVAGRQLVAGIMQGAVKG
>NZ_CP019229.1|WP_068751941.1|2034169_2035105_-|sugar-ABC-transporter-permease
MNQQLTRSQRLSRLDVKASPYLYISPFFILFFIVGLFPLVYTAWVSVHDWHLIGGQGEMVGLTNYIDVLQQPNFFKALRNTFSIFLLSSVPQVLAAIVIAYLLDTNLRAKTFWRMGVLLPYVVAPVAVSLIFAKIFADQSGLVNAVLEILGTSPIGWHADPFAAHVAIATMVNFRWTGYNALIFLAAMQAIPREIYEAAIIDGANRWRTFFSVTVPMLRPTIIFVVITSTIGGLQIFDEPRMFDTLGQGGADRQWMTLTMYIYELGWGAQKSFGRAAAVSWLLFLIIIAVGVINFLITRSISSSSSGKAGR
>NZ_CP019229.1|WP_068751942.1|2035179_2036493_-|carbohydrate-ABC-transporter-substrate-binding-protein
MVRAAIRNLAAVACVGALLTACSSGNGTTPDATQNGSASADPNEKVTLTVATFNEFGYEELFEEYMADNPNVTIEARKAATSNEARDNMNTRLAAGSGLADIEAIEIDWLTELMQYPDKFVDLADPELDGRWLDWKSAAVTTEDGKVIGYGTDIGPEAICYRADLFEKAGFPTDREEVADLLEGDWDTYFNVGKDFVAKSGGVAWFDSASATFQGMVNQVENPFENSDGTPIPLSENDEIKAIYDDIATAATDDNLSAGLAQWSEDWTNAFQTDKFATMLCPGWMLGVIEGNAQGVEGWDIANVFPGGGGNWGGSYLTVPEQGANHEQAKKLAAWLTAPEQQIKAFQAKGTFPSQVEALEDPALLDQTNAFFNDAPTGQILAERAKAIEVAPFKGPNYFALAQLVTDALNRLDVEGTDDAAGSWDKALEAYNALGLS
>NZ_CP019229.1|WP_068751943.1|2036699_2038220_-|lysine--tRNA-ligase
MARVTDASAPLPSDSEQTAVRKEKRARLLADGRDPYPADLTRSHTLRDIRAGWGHLEAGQETDDVVTTGGRVVFIRNTGKLAFATLQDGFGPEDTGERLQVMLSLAEVGEEALAAWKSDVDLGDFVWVTGRVIASKRGELSVMASGWRMAAKALRPLPVMHKDLSEEARVRRRYVDLIVRDEARDMVRKRSAITRAIRDTLYDRGFLEVETPILQLVHGGAAARPFSTHINAFDLDMTMRIALELHLKRTMVGGADRVFEMGRVFRNEGIDSTHSAEFTMLEAYMSWGDQGTVARLIQDVVQASADAVGSRQVETPKGTVDLDGEWPWLPVFPTLSEKLGEDVTVDTPLPELHRLADAHDVEYDPKWGEGKMVMELFAELIEPDLIQPTFVYDYPSIAQPLARQHRTDAGKVEAWDLIIGGLERGTGFTELVDPVIQREVLLAQSIKAAGGDPEAMQFDNDFIEALEYGVPPMGGLGLGVDRLIMLLTGVGIRETILYPLLRPSAG
>NZ_CP019229.1|WP_141680097.1|2038261_2038906_-|HAD-IA-family-hydrolase
MSVLGTFDAVIFDFDGTIADSVASMHRAYAVWAEEYGIELESLRQYTGRPAEAVARALVPADLAPAAGRRIDELEVSDVDGVVALPGASDAFAAIPSHLRAIATSCTTALLDARLGATGLPRPDVVVTRDQVERGKPAPDSFLLAAERLGVAPERCLVCEDAPAGVAAARAAGMPVLAVLTEHSAEELAADWAVGSLADVRFETVPEGVRVTLR
>NZ_CP019229.1|WP_068751945.1|2038902_2039187_-|cell-division-protein-CrgA
MPESRVRKSAVEKKKAKSRSELAEQRSETARLAPAGRSWVPAVFLPLGLIGVAWMVTWNLAYEHIGFMRALGDWNLAIGLGLIVASFVGMTMWK
>NZ_CP019229.1|WP_068752027.1|2039335_2040064_+|DUF881-domain-containing-protein
MGRNQLRERSGRGRATTILVCVLAGFMMTVAALAARGTDLRADRNADLRDLIVSQGRRNEELRLEADRLRAEVAALGDAAPDITSITGALDEAQLAASMVPVSGPGLRVVLTDAPNDVKPAGVDEDALVVHQQDIQAVVNALWAGGAEAMTIQGQRVIATTGIKCVGNTVVLHGIPYAPPYVIEAIGPQDGLAEGLAASPAVQIYQQYVDAYGLGYGEERVSTLEFPAFSGSTGVSVARASG
>NZ_CP019229.1|WP_068751946.1|2040109_2040748_+|aminodeoxychorismate/anthranilate-synthase-component-II
MAAILVIDNYDSFVYNIVSYLAQIGAEVEVWRNDDPRFADEGWYEPFDGVLLSPGPGTPEEAGVCIDVVRTLGGVRPLFGVCLGLQAMAVAYGGVVDRAPELLHGKTSPVFHEGRGVFAGLPSPVTTTRYHSLAIVEETVPDVLEVTARTESGVIMAVRHRELPVEAVQFHPESVLTEGGYQMLANWLAECGDADAPRRAATLSPLVTTALD

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Crispr_ID: NZ_CP019229_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_8

2530488-2530640

Orphan

Consensus_repeat	Method
GCGGCGTCGGCTTCGAGACTCGCCCGGGTGCTCCGCACCGGGCGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019229_8

>merge|NZ_CP019229|8|2530488-2530640|CRISPRCasFinder
GCGGCGTCGGCTTCGAGACTCGCCCGGGTGCTCCGCACCGGGCGCGACGTCAGCGAACGGGACGCCCCGACCTTAGCGAACGATGGGGTCGGGGGATCGACGCCCGCGGCGTCGGCTTCGAGACTCGCCCGGGTGCTGCGCACCGGGCGCGAC

>NZ_CP019229|8|7|2530488-2530640|CRISPRCasFinder
GCGGCGTCGGCTTCGAGACTCGCCCGGGTGCTCCGCACCGGGCGCGAC	GTCAGCGAACGGGACGCCCCGACCTTAGCGAACGATGGGGTCGGGGGATCGACGCCC
GCGGCGTCGGCTTCGAGACTCGCCCGGGTGCTGCGCACCGGGCGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_078920163.1\|2529150_2529957_+\|formate-transporter	unknown	unknown	gnl\|CDD\|182746
NZ_CP019229.1\|WP_068752652.1\|2519049_2519277_+\|DUF3073-domain-containing-protein	unknown	unknown	gnl\|CDD\|378620
NZ_CP019229.1\|WP_068752643.1\|2535728_2536544_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|224001
NZ_CP019229.1\|WP_068752645.1\|2533899_2534844_+\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240637
NZ_CP019229.1\|WP_068752642.1\|2536559_2537747_-\|galactokinase	unknown	unknown	gnl\|CDD\|223231
NZ_CP019229.1\|WP_068752638.1\|2540623_2541502_+\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695
NZ_CP019229.1\|WP_068752641.1\|2537743_2538562_-\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133024
NZ_CP019229.1\|WP_078920164.1\|2530750_2533813_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237859
NZ_CP019229.1\|WP_068752640.1\|2538626_2539244_-\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_CP019229.1\|WP_078920156.1\|2516642_2518856_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|377178
NZ_CP019229.1\|WP_078920158.1\|2520783_2522280_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|377965
NZ_CP019229.1\|WP_078920161.1\|2525163_2526645_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132848
NZ_CP019229.1\|WP_078920159.1\|2522525_2523161_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239460
NZ_CP019229.1\|WP_078920492.1\|2534887_2535790_+\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP019229.1\|WP_078920493.1\|2539646_2540627_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341285
NZ_CP019229.1\|WP_068752639.1\|2539321_2539573_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379161
NZ_CP019229.1\|WP_078920155.1\|2515639_2516635_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP019229.1\|WP_078920162.1\|2527542_2528976_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_CP019229.1\|WP_078920160.1\|2523287_2525198_-\|alpha-amylase	unknown	unknown	gnl\|CDD\|200463
NZ_CP019229.1\|WP_078920157.1\|2519194_2520262_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_078920163.1\|2529150_2529957_+\|formate-transporter	gnl\|CDD\|182746	PRK10805, PRK10805, formate transporter; Provisional.	6.38415e-93
NZ_CP019229.1\|WP_068752652.1\|2519049_2519277_+\|DUF3073-domain-containing-protein	gnl\|CDD\|378620	pfam11273, DUF3073, Protein of unknown function (DUF3073). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.45507e-16
NZ_CP019229.1\|WP_068752643.1\|2535728_2536544_-\|alpha/beta-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	0.00971752
NZ_CP019229.1\|WP_068752645.1\|2533899_2534844_+\|phosphoglycerate-dehydrogenase	gnl\|CDD\|240637	cd12160, 2-Hacid_dh_3, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	5.79374e-131
NZ_CP019229.1\|WP_068752642.1\|2536559_2537747_-\|galactokinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	1.83437e-36
NZ_CP019229.1\|WP_068752638.1\|2540623_2541502_+\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	1.09629e-102
NZ_CP019229.1\|WP_068752641.1\|2537743_2538562_-\|nucleotidyltransferase-family-protein	gnl\|CDD\|133024	cd04181, NTP_transferase, NTP_transferases catalyze the transfer of nucleotides onto phosphosugars. Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.	1.77589e-41
NZ_CP019229.1\|WP_078920164.1\|2530750_2533813_-\|glycine--tRNA-ligase	gnl\|CDD\|237859	PRK14908, PRK14908, glycine--tRNA ligase.	0
NZ_CP019229.1\|WP_068752640.1\|2538626_2539244_-\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	5.09041e-56
NZ_CP019229.1\|WP_078920156.1\|2516642_2518856_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NZ_CP019229.1\|WP_078920158.1\|2520783_2522280_-\|SH3-domain-containing-protein	gnl\|CDD\|377965	pfam08239, SH3_3, Bacterial SH3 domain.	3.73429e-07
NZ_CP019229.1\|WP_078920161.1\|2525163_2526645_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132848	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli. Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	3.11178e-12
NZ_CP019229.1\|WP_078920159.1\|2522525_2523161_-\|hypothetical-protein	gnl\|CDD\|239460	cd03344, GroEL, GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found in eubacteria (GroEL) and in organelles of eubacterial descent (hsp60 and RBP). With the aid of cochaperonin GroES, GroEL encapsulates non-native substrate proteins inside the cavity of the GroEL-ES complex and promotes folding by using energy derived from ATP hydrolysis.	3.10302e-09
NZ_CP019229.1\|WP_078920492.1\|2534887_2535790_+\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	9.43311e-78
NZ_CP019229.1\|WP_078920493.1\|2539646_2540627_+\|AMP-binding-protein	gnl\|CDD\|341285	cd17630, OSB_MenE-like, O-succinylbenzoic acid-CoA ligase. This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.	6.14742e-66
NZ_CP019229.1\|WP_068752639.1\|2539321_2539573_-\|hypothetical-protein	gnl\|CDD\|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	9.9311e-05
NZ_CP019229.1\|WP_078920155.1\|2515639_2516635_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	5.33148e-95
NZ_CP019229.1\|WP_078920162.1\|2527542_2528976_-\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	5.07925e-26
NZ_CP019229.1\|WP_078920160.1\|2523287_2525198_-\|alpha-amylase	gnl\|CDD\|200463	cd11324, AmyAc_Amylosucrase, Alpha amylase catalytic domain found in Amylosucrase. Amylosucrase is a glucosyltransferase that catalyzes the transfer of a D-glucopyranosyl moiety from sucrose onto an acceptor molecule. When the acceptor is another saccharide, only alpha-1,4 linkages are produced. Unlike most amylopolysaccharide synthases, it does not require any alpha-D-glucosyl nucleoside diphosphate substrate. In the presence of glycogen it catalyzes the transfer of a D-glucose moiety onto a glycogen branch, but in its absence, it hydrolyzes sucrose and synthesizes polymers, smaller maltosaccharides, and sucrose isoforms. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP019229.1\|WP_078920157.1\|2519194_2520262_+\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	5.17578e-32

>NZ_CP019229.1|WP_078920163.1|2529150_2529957_+|formate-transporter
MATPAEMARLVQDTMLYKAQATVPRTLLLSLTGGGYIALGFVFYVTTQVGAEALPWGVAKLLGGVVFSVGLILVVLTGADLFTSTTMTLMLKASGHLSWWKLLRHWGLVYLGNAAGALTIVALMVLGGVQHSANGAWGQVVLTAASHKLDHSFIEALALGVACNLLVCLAVWAAFSGRTTTDKIMALVGPVALFVATGFEHSVANMFLVPLAIFIQPELAPAGVEHLGWWTFLTANLVPVTLGNIIGGGLMIGLFYWLVFRPKRGAGR
>NZ_CP019229.1|WP_078920162.1|2527542_2528976_-|HNH-endonuclease
MSDLRDLGQRHLAALWDAARSLAQDPGAAAERLGTLVTAVTEAEAQLAGLRLHLLHEAKLAAAESVIDGVRQSVRTTPAQATASLRLAQDLGDRFPLIGAALNDGSISLAQADAIVTGLRKLPGRLTRAELTRCEEKILHHTDTLGPSELRVLAARLVEIIDPDASDADDAKRLAREEAAAHRGRFLRLAPDYHGSMRITGQLPGADAALLSAQLDALMPDASTYLAAGEAPSRDARRADALVLLTQKAATSGALPAHGGDRPQVHVTLDLDTLTTGLGRVGLIGLDDVDGLSAGEVRRLACDAGIIPVVLGGPSRLLDVGRTYRMFTPGLRAALVQRDGGCAFPGCAATPACCEAHHIVPWWQGGVTRLGNGVLLCPHHHRLVEPDPLQSEQSQWRVDLDPVTGLPWFTPPRHIDPARRPRQHRRFRLQQIRAGAPPGADGDPPDGDPPETESSDAGRPDLDDLIRRSAHIWGDGT
>NZ_CP019229.1|WP_078920161.1|2525163_2526645_-|patatin-like-phospholipase-family-protein
MAGKGWFGLPFFGQSPREERVSCTLSGGGSRASFQLGALDYLYRHDDDFTPTAFVGASAGAILAATLAQSATRDGQIAFLRRLDDIWMGMTSQTDMFTPRPWFSRLQDEGPAWLQVMAPPPPAPRTPWIRPGILPFRRPSPASPVTPPEPTALDPLELALAPDDETVRSDWSLAVLSGLANQLGRLPRIGSELNSIWHGVERSRSMYRPGPMLRDLLDPATFDPSRVAGSGATLRIAMVALETGELHFMTETGRLVDRTDQPVGPEVHDLPVGVLASCAIPAVFRPVPIGDLTYVDGGARENLPAELAVGHLGAGRNYVISSQSQGVPRRASMADADLFSVVMRSTEILIDEAGRDELAYAHSAGAFVVHPEIAVHDSMTVHPGLLAINRDYGWLRAAERHLALGESTESLHRVIIELRMRILQLEEQVISSPGPVRRDQLALRSAKIQLRDAVRAARDTPFPDGADTWWTTWERHPVPPTGDPPWMPLPPQG
>NZ_CP019229.1|WP_078920160.1|2523287_2525198_-|alpha-amylase
MRRGCRCRHRGETRLRKVKTTFDLRWERYGADLIAALESVYGERAWEVTDRVRELVRAKFDQRSDELRELDEARLLRPDWLQLPSQVGYVAYTERFAGTLTGITGHVDYLQDLGVTYLHLMPLLQPREGANDGGYAVADYRTVRPDLGTMADLEALTGQLRGHGISLVVDLVLNHVAREHEWAVRARAGEQKYRDYFMVFPDREKPEQYERTLPEVFPDFAPGNFTWDDDLGGWVWTTFNDYQWDVNWANPDVFVEYLDLILDLANLGVEVFRLDAIAFIWKEMGTDCQNEPPVHAITQALRQAARIAAPAVAFKAEAIVGPKDLIAYFGTGEHHGKLSDIAYHNSLMAQLWSTLATHDTTLLRRALGAFPPKPATATWGTYVRCHDDIGWAIDDVDAATAGLNGAAHRRFLSDFYSGEHPGSFARGLVFQANPATGDRRISGSLASLAGLEAALKAGRPYDVELAVARINLLHAVIAGWGGIPLIYMGDELAMLNDHDFVRDPAHAEDNRWVHRPVMDWAAVAALGENPSSPAARVNAWLRHVLAVRRATPHLHASREAEFLETGDPRVLAIRRDHPLGPMVQVYNFSPTEVTVPMGCLAETLGETGHELLDDVAWDLTPWVMTLRPYAVHWFTA
>NZ_CP019229.1|WP_078920159.1|2522525_2523161_-|hypothetical-protein
MPAWSWFAIALTVGVGLLALAATADRRSSRRRAGVGVPAPRRDVPDVDRHVPRYVTQHEIDALPRPYEPDAGLGPRTGEGFRFGHAHADFATAPAGADLRDPLILVVDGAVTSMRELLAPLGAATAEHPLVVVAASLHPEVIQTLAANRRALRLPVLAAVADARDRRRLAELTGGEELTEADLRAGYLPEAAFGRAERWTSTATRTWVTTA
>NZ_CP019229.1|WP_078920158.1|2520783_2522280_-|SH3-domain-containing-protein
MTRALSVRGSGRTCRGPTKPRGSGTSDLTEISHMRRDVRTALKGLRGLASAAGIAVLVQGLGTLAAGPLADAQLGDVTATTAVNIRTAPSTSGSKLGLLYRGQSLPSLGSANGWTKVTYNGRTAYIASAYLKGGTAAAGPSSETTNGTSQGSTGAVYTTANLNLRTGPSTSDRIGVVVQRATALQLTGKVSGTWAQVTYKGVTYWAAIRYLSATAAQAYSELPKVTGKARATTALMIRTTNTTSFVNLGDVPRGTILDVTGVVTNGVAQIVYNGAVRWVNARYLVAVDAATPAPTVPATPATTTRYATTVLNIWTASSGTSFVGEIPKGTEIQVTGVVENGRAQAVVNGAVRWFTARYVSATKPADGTASAGSGTTLNRGYSSGLDQTNANVQAITRDIWNRYPAIKTMYGWRRDVTPDHPAGRAVDVMIPSYSSNQALGWEIANYYRAHAKEYNINYIIFAQKIWSVARDSEGWRLMADRGSDNANHYNHVHINTYG
>NZ_CP019229.1|WP_078920157.1|2519194_2520262_+|alpha/beta-hydrolase
MRTQTSLRARDWQKATRTTTSTSAVPPDAQRQWLPDTELPGYELLPIPLPDEPTYALEPDGSLVATVVRRSHPVSRRAVLYVHGWSDYFFQRHLADEMAALGYDFYAVDLRRYGRSLRDRQLAGYIANLSDYFTELDEALEVVRSEGHDDVVLMGHSTGGLTASLWAHERPGAFSAVVLNAPWLELQANSLLRPATQPVLSAARAVAPTTALPQLDTGFYRRCISSSEEGEWDYNLNLKGDPAFLIRVGWMAAILDGHARVAAGLSIDCPVLVAISARSDFRRSWDEGFRLADIVLDVDRIASRAPKLGDLVVIARIPDAMHDLVLSRTDVRERVFSEYSRFLTAYAPEADRAAN
>NZ_CP019229.1|WP_068752652.1|2519049_2519277_+|DUF3073-domain-containing-protein
MGRGRAKAKQTKVARDLKYRSIDTDFSSLERELRGGSFVEESTEDEIPDAYADLVEGAGLAEGYEDDDEYERRSS
>NZ_CP019229.1|WP_078920156.1|2516642_2518856_-|NADP-dependent-isocitrate-dehydrogenase
MGKIIYTLTDEAPLLATYSFLPIINAFAGQAGVAVETRDISLAGRILAQFTDRLPEDQRVDDALTELGELAKTPDANIIKLPNVSASVPQLKAAVAELQSQGFQLPDYPEDPQTDEEREVRARYDRVKGSAVNPVLREGNSDRRAPESVKNYAKKNPHRMGAWSSDSRTRVATMDANDFRHNEQSVILPSADTLTIRHRSADGTETVLKESLAVLEGEVVDATVMRASALDAFLREQVAAAKESGVLFSVHLKATMMKVSDPIIFGHVIEAFLPEVFERFGADLAAAGLSPNDGLGAILAGLDSLPNGADIRAAIEQGIADGPRLAMVNSDKGITNLHVPSDVIVDASMPAMIRQSGHMWGPDGEEDDTLAVLPDSSYAGVYQAVIEDCQANGAFDPRTMGSVPNVGLMAQKAEEYGSHDKTFEIPSDGVVEVVDASGSVLMSHDVAAGDIWRACQTKDAPVQDWVKLAVTRARVTGAPAVFWLDEERAHDRNLIEKVRGYLADHDTDGLQIEIMNPVDATRFSVERIRRGEDTISVTGNVLRDYLTDLFPILELGTSAKMLSVVPLMAGGGLFETGAGGSAPKHVQQLVEQNYLRWDSLGEFLALAASFEHLADREGNARAKVLADTLDRANARFLDQDKSPTRRVGGIDNRGSHFYLALYWAQELAAQSDDAALAKVFGPVAEKLAASEQQIVDELIAVQGSPADIGGYYRPDDAKATAVMRPSDTFNGIIATLD
>NZ_CP019229.1|WP_078920155.1|2515639_2516635_+|LacI-family-transcriptional-regulator
MSEVRRRSGAPTIHDVARLTGVSAQTVSRVLNTPDRVQPATRERVMAGIRQLDYRRSPMARGLATNRSGAIGVVDSGSGVMGQMLLLSAVEAAARDHGYSPRVITTSDTDAASLRRALETLHNERVEGIVVMGNTTLHVRGAIWAAGRTPVVLVASDEPPAERLSTVSVNQAGGARELLLHLRAHGPRIGHIAGPRGWVDADARREEWRRFAGDEHAHLVAEGDWTAGSGYAAMQRLLDQGVDAVFASNDYMALGALQACRERGLSVPGDVAVTGFDDIPGADFFYPPLTTVRQPFRELGIRAVDLLAELLSGQEARSELLQAELVVRSSS
>NZ_CP019229.1|WP_078920164.1|2530750_2533813_-|glycine--tRNA-ligase
MLTMQDALRRLSDYWTSKGCLTWQPFNTEVGAGTMNPATVLRVLGPEPWDVAYVEPSVRPDDSRYGENPNRLQMHTQFQVILKPEPGDPQELYLGSLEALGIDLAKHDVRFVEDNWAQPAIGAWGLGWEVWLDGMEITQFTYFQQVGGQNLDPIPVELTYGVERILMAQQGVTHFKDIVYSVASDGRPVTYGEAFGQQEYEMSRYYLDDADVEANRRLYETYVAEATRMVEARLPVPAHGYILKSSHAFNVLDARGAISTTERAKAFATMRRLMRDTAALWIERREELGFPLLREPKAVEPAAEESVDRAALGDAPRTLAFEIGVEELPPHVVPQTVDAVREALTAKLAATRLEYGAITVDGTPRRIVAVVEGLAASEPDAEQLRKGPKWAAAFDADGKPTKALEGFMRGQGVDASQVVKAEIGGQEHAAVAATVAGRHVLDVAGQAIADIVGGLRAEKNMRWNDASLSFSRAIRWLVALWGEAVVPVSVSGLTAGRRTYLQRPVGDQATSGVRPDGARVGWVHVASADELTRTIADGAITLSTAERRASVVAQAEALAAGVGGTVDVEADAAVVDEITNLVEDPRGVLGHFDERYLDLPARILTTVMRKHQRYLPVYRDGALAPHFVTMANGLCDDDTVRAGNESVIRARYEDALFFWNADLTADDVESFVPGLDQLTFEDRLGSVGMRARRIADVAARLADRVGLAGDERATLERAGRLAKFDLATQMVVEMSSLAGFIAREYAVRKGETQAVADALFEMEQPHTSADPVPASTPGALLALGDRFDLLAAMFALGAKPTGSSDPFGLRRAALGVVRILRESAGTPLETLTVRAGLEDAVARLAEQGVAVAEDAVDAALEFTVGRFAQLLRDEGTPAELVAAILPAADAPGRAARLLRELVAAREDVRLRALVSTLVRIDRILPVGTASGYDAALLTEPAEAELRAAVEAVPAGAADESIPALLDATGDVVAAADRFFTDILVNAEDQAVRAARQGLLASVLSLAPSGIDWRALDIALG
>NZ_CP019229.1|WP_068752645.1|2533899_2534844_+|phosphoglycerate-dehydrogenase
MKILVPDAYRGALPHIDDADVVVIAAGEPVPEEHVDAEVLVVWGQPLDVLTDAARRMRHLRLVQGLLAGPDILRAAGFAPDVALASGVGLHDGPVAEHALALTLALVRMLPLAMRRQREHAWDAVLGGAMLERAHDGRVISLEGAQVTVWGFGSIASRLAPLLRGMGAWVTGVARSAGPRHGFDVVAEDSLPEVLGRTDVLIMILPRDESTHAALNAKRLKQLKPSALVVNVGRGTTVDEDALLAALRSGHVAGAALDVTAVEPLPESSPLWDEPSVIITPHVASGRPQRAERLIEANVAALREGGDITNLMAR
>NZ_CP019229.1|WP_078920492.1|2534887_2535790_+|cation-transporter
MSQPRVDLTKFAWLSIAAALATIALKTAAWWVTGSVGLLSDAAESVVNLIAAVVALFALRVAARPADKNHHFGHSKAEYFSSAIEGVMIFVAAAAIVGFAIERLIVPRPLEEIGIGLVISVVAALVNGAVAWVLLRAGRRYNSITLRADAHHLFTDLVTSAGVVVGVVLVGVTGWNWLDPVVALLVGINILWTGWRFVSESASGLMDESLPKEDNARLRQILTDHESDEVHFHAFRTRISGARAFMEFHMLVPGAWSVQRGHDAMEDLIDLIRSEYTELRVIGHLEPIEDPRSYEDIHID
>NZ_CP019229.1|WP_068752643.1|2535728_2536544_-|alpha/beta-hydrolase
MGSPTMRAARLASELRRARHAAGDWTVAARDMAAALWSRRRWHPESASDPGPACADITVVLLPGILEPWSYLAPLARWLGRRGHRVEFVETLGWNDADLEQSAERCLGVLRERGLRRVVLVAHSKGGLIGKAVLLRQGDEDLAVGLVAVATPFGGSSVGRRLHRLVARSPLGLFSPGNAVLGGLAAELAVNARIVSLAPAWDQVIPDGSHLTGATNVDLAVGGHFRPLRDEAVWRLIHEHAHRRAEDAPEGPSRCGCPRSCEDPRSVRGGR
>NZ_CP019229.1|WP_068752642.1|2536559_2537747_-|galactokinase
MTWFVPGRLEVLGKHTDYAGGSSLLAAVDRGVTVSLSDGDSGVTATSTALPGELRLAAGASPALPPGHWGHYVQSVLDRLALNFGDLRPARLVVDSDLPLASGMSSSSALVVAVALALIDHNGLRDRDEWRSAIADDIDLAGYLATMENGLSFGPLEGRRGVGTFGGSEDHTAMLCCREGRLSEFAFCPIVERGSVPMPEGWSFVVAVSGVLAEKTGAALEAYNEASALAREIVDEWNDVMGRSDATLADALASGEDAMLALEAITEHDEWWSDRLRAFLTESTVAIPRALAALRSGDVAAFGAAADLSHRTADEALGNQIPETNRLQALARALGAPAASGFGAGFGGSVWAMAPTADADGFAAEWLARYLAEFPDAAARATTLVTRPGPPAHRV
>NZ_CP019229.1|WP_068752641.1|2537743_2538562_-|nucleotidyltransferase-family-protein
MSVDTPRKAVILARGLGSRMRKEADGVALDAAQARAADAGVKAMISVGRPFLDHVISALADAGFTDVCLVIGPEHGMIRDYYDGLETSRVTIHYAVQAEPRGTADALLAAEEFAGEDRILVINSDNYYPAEALRMLADAPGSALVGFDRAALVAGSNIPADRIAAFALATVDAEGNLAELGEKPDADTLARLGGHALVSMNCWLCSPAIFPAARAIEPSARGEYEITDAVRRAIADGDPYRVVRAAVGVLDMSSRGDISSVVAALGDREVRL
>NZ_CP019229.1|WP_068752640.1|2538626_2539244_-|dihydroxyacetone-kinase-subunit-L
MGGVNAVAAWLGDCAREFARRADELDELDRLLGDADHGTNMRRGTEAAGAIDLSETRTAAEALRKVGMALVSTVGGASGPLFGTFFLRTGAAWPSQVTTAGVARAMRAGLDAVVIRGRAREGDKTMVDALAPAVRALESAAAAGQDLSEALPAAAAAAERGRDATRDMVARRGRAALKADTSVGVIDPGAVSVAIIVTTAATHVR
>NZ_CP019229.1|WP_068752639.1|2539321_2539573_-|hypothetical-protein
MARVLLIIAIVMLTVYCVVEVAQSRGYRVRAMPRWLWAFAVIAVPVVGPVAWLLLGRPVKDHPRLDRGPSAPDDDEDFLRGLR
>NZ_CP019229.1|WP_078920493.1|2539646_2540627_+|AMP-binding-protein
MLAGGDGLWLADGPGEAPPGTAVVGTSGSTGSAKRVILPREALAAAADAAHQRLGFAPTWHLALSPRYVAGLMVLVRGVLGGGVRGADPSLADLTPAPGHNAVSLVPTQLYRALGDPERAAVLAHFDAVLVGGAALDRGLRARAEAAGVPVVSTYGMSETCGGVVWDGVPLPGVDVRLGPEGRIAIAGPTLFRGYLDRPDLTAEALVDGAVLTRDRGHTEPGGRLVVEGRLDDVVISGGVNVDLAAVRGAVAGIDPETEVLAVADDEWGVRLVLFARGGDLAGWRDRLRGALPAAALPRQLVCVDPLPRTAGGKPDREKLLELLRS
>NZ_CP019229.1|WP_068752638.1|2540623_2541502_+|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MNEKLSVWVAGARPRTLPAAVAPILAGTAGAAAVGHTGWGLAALCLLVALALQVGVNYANDYSDGVRGTDDQRVGPTRLVASGLATPAAVKRAAFLAFGVAGVAGLAVVALSGHWWLLLVGILCILAAWYYTGGSRPYGYLGLGEVMVFVFFGLVATVGTGYVIAGVAPAHLWLAATAVGVLASAILVANNLRDIATDRVAGKMTLPARLGDRATRRFFALLVLVAVAAVVGYAALTTWWALLALAGAVVLADPLRRVLGGATGRELIPVIPATGFAEIGIAAGLLVGSLVG

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Crispr_ID: NZ_CP019229_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019229_9

2699339-2699573

Orphan

Consensus_repeat	Method
TCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP019229_9

>merge|NZ_CP019229|9|2699339-2699573|CRISPRCasFinder
TCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCTTTCCCGGTCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCTTTCCCGGTCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCTCGAAGGGTCGTGACGTTCGCTTGATCGCAGACCTGGGGCCAGCCCCACCGCGCATCCCCTCCATCTCGAGGTCCCCACCGGTCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCT

>NZ_CP019229|9|8|2699339-2699573|CRISPRCasFinder
TCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCT	TTCCCGGTCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCTTTCCCGG
TCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCT	CGAAGGGTCGTGACGTTCGCTTGATCGCAGACCTGGGGCCAGCCCCACCGCGCATCCCCTCCATCTCGAGGTCCCCACCGG
TCCCTGAGGAGATCGGCGCGGAGCGTCGATCGTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019229.1\|WP_153302461.1\|2696524_2697214_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP019229.1\|WP_068749407.1\|2708468_2709194_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273884
NZ_CP019229.1\|WP_078920199.1\|2689629_2690637_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378117
NZ_CP019229.1\|WP_078920198.1\|2688793_2689633_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP019229.1\|WP_078920206.1\|2703269_2704214_-\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NZ_CP019229.1\|WP_068749410.1\|2705858_2706602_-\|DUF554-domain-containing-protein	unknown	unknown	gnl\|CDD\|377371
NZ_CP019229.1\|WP_078920207.1\|2704272_2705226_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP019229.1\|WP_078920196.1\|2685141_2685564_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380033
NZ_CP019229.1\|WP_078920204.1\|2697350_2698700_-\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|366058
NZ_CP019229.1\|WP_068749411.1\|2705194_2705836_-\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|184638
NZ_CP019229.1\|WP_068749409.1\|2706704_2707427_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP019229.1\|WP_153302419.1\|2700742_2702506_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP019229.1\|WP_078920205.1\|2699881_2700202_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NZ_CP019229.1\|WP_068749408.1\|2707428_2708472_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187556
NZ_CP019229.1\|WP_153302420.1\|2702509_2703265_-\|DUF4191-domain-containing-protein	unknown	unknown	gnl\|CDD\|379389
NZ_CP019229.1\|WP_078920202.1\|2694144_2695566_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_CP019229.1\|WP_078920500.1\|2698992_2699319_+\|transporter	unknown	unknown	unknown
NZ_CP019229.1\|WP_078920200.1\|2690821_2691787_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|176248
NZ_CP019229.1\|WP_078920197.1\|2685619_2688538_+\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613
NZ_CP019229.1\|WP_153302460.1\|2691827_2693897_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272

Protein	Function_ID	Function_description	E-value
NZ_CP019229.1\|WP_153302461.1\|2696524_2697214_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.38214e-71
NZ_CP019229.1\|WP_068749407.1\|2708468_2709194_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|273884	TIGR01934, methylase_mitochondrial, ubiquinone/menaquinone biosynthesis methyltransferases. This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	1.97448e-32
NZ_CP019229.1\|WP_078920199.1\|2689629_2690637_+\|hypothetical-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	6.17876e-23
NZ_CP019229.1\|WP_078920198.1\|2688793_2689633_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	3.54897e-47
NZ_CP019229.1\|WP_078920206.1\|2703269_2704214_-\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	1.25278e-178
NZ_CP019229.1\|WP_068749410.1\|2705858_2706602_-\|DUF554-domain-containing-protein	gnl\|CDD\|377371	pfam04474, DUF554, Protein of unknown function (DUF554). Family of uncharacterized prokaryotic proteins. Multiple predicted transmembrane regions suggest that the region is membrane associated.	6.69612e-69
NZ_CP019229.1\|WP_078920207.1\|2704272_2705226_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.95358e-14
NZ_CP019229.1\|WP_153302419.1\|2700742_2702506_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	4.46092e-160
NZ_CP019229.1\|WP_078920204.1\|2697350_2698700_-\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	1.39526e-100
NZ_CP019229.1\|WP_068749411.1\|2705194_2705836_-\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|184638	PRK14345, PRK14345, lipoyl(octanoyl) transferase LipB.	1.81496e-97
NZ_CP019229.1\|WP_068749409.1\|2706704_2707427_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.9246e-05
NZ_CP019229.1\|WP_078920205.1\|2699881_2700202_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	3.91932e-24
NZ_CP019229.1\|WP_068749408.1\|2707428_2708472_+\|NAD(P)H-binding-protein	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.8996e-114
NZ_CP019229.1\|WP_153302420.1\|2702509_2703265_-\|DUF4191-domain-containing-protein	gnl\|CDD\|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	1.16293e-85
NZ_CP019229.1\|WP_078920202.1\|2694144_2695566_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP019229.1\|WP_078920196.1\|2685141_2685564_-\|hypothetical-protein	gnl\|CDD\|380033	pfam17844, SCP_3, Bacterial SCP ortholog. This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.	4.12381e-27
NZ_CP019229.1\|WP_078920200.1\|2690821_2691787_-\|oxidoreductase	gnl\|CDD\|176248	cd08288, MDR_yhdh, Yhdh putative quinone oxidoreductases. Yhdh putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	3.31761e-148
NZ_CP019229.1\|WP_078920197.1\|2685619_2688538_+\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0
NZ_CP019229.1\|WP_153302460.1\|2691827_2693897_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.4913e-80

>NZ_CP019229.1|WP_078920500.1|2698992_2699319_+|transporter
MIGDWAASMIVAIALFGFDVMTGSGWESFMILAVYFVEASLLTALAGGSFGQLIARIGIVRVDGGPLGWWRPVVRTALKCLVIPAMVVGAERRALTDLLLGTVVVNRR
>NZ_CP019229.1|WP_078920204.1|2697350_2698700_-|dicarboxylate/amino-acid:cation-symporter
MSTISSERAPETTAPPRKPFYTNLGFQIVVGLVAGVVLGLIAVAIGPDGEERNWLAGLLYEVGGAYVSLLTLLVVPLVVTAVISSIARLREVTNAARLAVQTLIWFAITALASVIVGIGVGLISSPWLTAGVDAEAAAAPGRVGSWTAFLTGLIPNNIFGLGVRISGDAESGFAASPSFSVLQVLLISILFGIAAVKVGDKAAPFVGFMESALSVIQKVLWWIIRLAPIGTAALIGRAVATYGWSSLASLGTFVAALYIGLIIVWAVVYPAILKFHGLGVREFYRNVWPAISLGFVTRSSMGTMPVTEQVVERNVGVPRQYASFAVPLGATTKMDGCAAVFPALASIFVAQFYGIDLGLTHYLLIAFVAVLGSSATAGTTGATVMLTLTLSTLGLPLEGVGLLLAVEPIVDMGRTALNVTGQALVPAVVAKREGILDEATYSARPQFSA
>NZ_CP019229.1|WP_153302461.1|2696524_2697214_-|ABC-transporter-ATP-binding-protein
MVVHRASHEVLHGVSFTLAPVSVTGLFGPSGCGKTTLMRTMVGVQHITSGRLELLGLPAGHPDLRRRVAYTSQSLSIYRDIPVRANVRYFARLHGLPDAAAEEAIAAVDLTPLAGRRVETLSGGEASRASLACALVGRPEVLILDEPTVGLDPLTRESLWSHFRGLAESGTTLLVSSHVMDEATRCDSVLLMRDGHFLADGPMGDLQERTGAPTPEAAFLTPVRAEAGA
>NZ_CP019229.1|WP_078920202.1|2694144_2695566_-|type-I-glutamate--ammonia-ligase
MFQGADDLLAYIKDEGIETVDVRFCDLPGVMQHFTVPASSFGREVFEDGLGFDGSSITGFQKIHESDMALMPDPTTAYVDPFRKSKTLNVNFFVHDPLTKEPYSRDPRNIARKAQAYLASTGIGDTAFFAPEAEFYVFDDIRFETTANSSYYHIDSEAGAWNTGRVEDGGNRGYKVKYKGGYFPVAPVDHFGDLRDDIVRHMEAAGLEVERAHHEVGTAGQAEINWRFDTLLKSADDVMKFKYLVKNTAWAAGKTATFMPKPIFGDNGSGMHCHQSIWNEGKPLFYDENGYAGLSDLARWYIGGLLKHAPSLLAFTNPSVNSYHRLVPGFEAPVNLVYSQRNRSACIRIPITGSNPKAKRIEFRCPDPSSNPYLAFAAMLLAGIDGIQNRIEPMAPIDKDLYELPPDEHAQVPTVPGTLGAVLDNLEADHEFLLVGDVFTPDLIETWIELKRAEIQAIAMRPHPHEFELYYAI
>NZ_CP019229.1|WP_153302460.1|2691827_2693897_-|MMPL-family-transporter
MGGPYFGRIEEVATNDQSTFLPTSAEATVVGERYLDFVDSSTLPAIVLFSSDDALSPDVLTELQERAATLADIEGVESVSPLIPSEDGLAAQVFAGVDAEASIAEVVDVIREDLPGGLPDGVTTYVTGPAGFTADITEAFSGIDGLLLAVALAVVLVILLVVYRSLILPFAVLATSLFALAVALLANWWLAKAEIVTLTGQTQGILFILVIGAATDYSLLYTARYAEELKRRASKADATRAALKGVVEPILASGGTVIAGLMCLLLSDLGSSRSLGPVAAIGIIFAMLAALTLLPSLLYLMGRASYWPRRPRFDPNRDEDAEVTTGIYAQAARLVAARPRVVWVVCALALAAGAAFVPTLKADGVPPSEFVLGASEARDGQAELAEHFPAGSGNPARVLTDEARLQEVADLLLSSDGVDSVSVVAADSPAGTAPVTADGVQPLGPPGTPAPAPTVSEGQVMLLATLADAPDSDEAGDTVRALRADLDGRAQIGGETATNIDTRDTSIRDRNLIIPLVLVVILLILIVLLRSVLAPVLLILTTVLSFGTAMGTAALVFNHVLDLPGADPSVPLYGFVFLVALGIDYNIFLMTRVREESLVHGTRPGILRGLAVTGGVITSAGLVLAATFAALAVLPILFLLQLAFIVAFGVLVDTFLVRTLLVPALSYDIGPRIWWPARLEADRAAHAAE
>NZ_CP019229.1|WP_078920200.1|2690821_2691787_-|oxidoreductase
MRGIVVRDSGVALEDGCEELLADDGVLVEVVYSDLNYKDALAVTGRPGVVRQKPLIAGIDLVGRVVESADERWTPGQWLVLNGAGLSETRHGGYAELARADADLAVPVPDGLTPERAAALGTAGYTAALAVLRLVRDGVSPDSGPVLVTGATGGVGSVAVMLLAAAGFDVAALTGREDRFGDYLRDLGASSIVGRQALGEPGRPLQKALYAGVVDSVGGQVLANAIAQTQPHGVVTACGLAASPDLPATVMPFILRGVTLAGIDSVWAGVEDRADAWRVLARGVDLDQLDQMTDRVGLDGVIAAGEELLAGKRHGRTLVEI
>NZ_CP019229.1|WP_078920199.1|2689629_2690637_+|hypothetical-protein
MISRRSVLLGGLAAAGATGLAACSGASPAASPSADGKLTVGLTYIPNVQFSAFYLGVAEGLFAKQGLDVTLRHHGQQEDVFGAVLAREEHVVFASADEAMVASAAGQDLRTFATSYQTYPLEVMGGGDLGLSADDGLAVLAGRTLGIPGHYGSSYYAALAAIHEAGLTEDDVTLMDIGYTQLSALAARQVDFIMGFRNNELVQLRAQGESVLSIPISDPASPRLVGPSLVTVGTEVSDDVLAAVARGMREAEEAVIADPEAALDATAEQVPALSDPAQRESAARVLAATTELWTRGGAVDVSLDTDAFARMAEFLVEAGIIERAPEQAYVELDLS
>NZ_CP019229.1|WP_078920198.1|2688793_2689633_+|ABC-transporter-permease
MTLEERRRARSLAHLGVWSAYPARTRPSAGRWKPAAAALGGVLLLWWAVTAGGLIAPLYLPNPLDVVARMGTQLTTGVAWRYLAPTLGAALLGALIAVAVALPLGVVITHSRLFAAVVEPFVAISQTVPLVAIAPLLVLWIGYGTVPIAVLCAIIAFFPMVTTTVVGLRSLDMRVVENALLDGAGAWQRLVHIEGPMAAPAILAGVRGGVVLTMTGAVVGELVMGGAGLGTLLTLTREAADTAGLFAVVAWISLTALTLHGLVHALERAAVARLQGETT
>NZ_CP019229.1|WP_078920197.1|2685619_2688538_+|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MSRYQSQTGEFARRGFDSATASAAIWEKWQRRIDGDPPLDLAIFEPVADRDLALDSLERISSADPSLFERIAADPAWLGRVVLVLGGSSVLAQTLVRHPEEAEILREESGPRGRDGWMDFFTARVGPVGGVASGNGDALRLANRVALIAIAARDLGAPDPLAVADDIARELAHVADAVLELSLAYARAEVPGWEKARLAVLALGKTGAEELNYISDVDVLYVAEPADGADAEEAVTVATRLAAAQARLCSAHTAEGTIWQVDSALRPEGKAGPLVRTLASCRAYYERWAKNWEFQAMLKARPAAGDLALGQAFVDLVWPMVWQAGERPEFLAEVRAMRERVISLIPAKQAEVEIKLGSGGLRDTEFSVQLLQLVHGRADERLRVRGTFSGLRALVGSGYIGRADGAEMADAYRFQRALEHRVQLRRLRRTHLVPDDETALSHVARSLGLTSDELRARWRDSTRRVRRLQQRIFFSPLLDAVSHVPADGLRLTPEAATTRMHALGFADPQAALGHIQSLIRGTDRRAEIQRQLLPAMLEWFAEGPNPDFGLLAFRQLSEALGTTSWYLRTLRDEGYMAHRLARIASTSRYVVDLLKRNPDHIQMLAGNDDLRPRTAEELTEAMTRAAARQDDPDKAVASVRALRRAELCRIALSDVLGLADLAAVGTALSDLASATVDAGLQVARRRVTAPEVGVIALGRWGGREMGYASDADCMFVVADGTEGEDLTRATELIRYATEIIGKPGPDPALVIDTDLRPEGKGGPQARTVSSYAAYYGKWASTWEAQMLLRARPGAGDRALAEAVLDAVEGFRYPEGGLTREQVGEIRRLKSRMETERIPKGVPRERHLKLGPGGLSDVEWTVQLLQLRHAYDHPGLRTTSTLPALRLLAQLELLPQAQAVRLEEAWVRASSLRDAIMLVRGRAGDALPADFRELAAISVLLGYGPGEASRLLDDTRRLLRRAGDVVDAVFWKG
>NZ_CP019229.1|WP_078920196.1|2685141_2685564_-|hypothetical-protein
MFKPTPAVVAALRERLGAADPALDAELARRRPDLTRLLLRAAADPEPLARELVAAVCRAGCGLLGERHPGPTIEVRVPPYAAVQIGFGTGPVHTRGTPPNVVEMSPETFVGLATGRLSWGDARINASGAHAAEAARAFPL
>NZ_CP019229.1|WP_078920205.1|2699881_2700202_-|GIY-YIG-nuclease-family-protein
MTGMAWTYILECADGFYYVGSARDLDQRAWEHEIGSGSRFTAKRLPVKLVWAQEFDNIGEAYAMERRLHGWSRAKKAALIAGRFDEVSRLARRGASRSHETDRKRE
>NZ_CP019229.1|WP_153302419.1|2700742_2702506_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MANLVNLEGVSHGFGTRILLDSVSLGLSAGEVIGVVGRNGDGKTTLLRILTGELEPDSGRVTVATNSSIGVLTQATIGDDAQTIRDWIVDGEPDHVWAADADKRAVVEALVADLDLDRRLDTLSGGERRRVGLVAVLLGHHDLVVLDEPTNHLDVEAIAFLATHLQARTRAGLAMLVVSHDRWFLDAICTRIWEVHDGVVDAYEGGYAAYVLARVERQRQAAANESRRRNLARKELAWLRRGAPARTSKPKFRIDAANVLIADEPEPRDKLALQQFAVTRLGKDVFDLINVQYAVDDRTLLDRLTWSIGPGDRIGLVGVNGAGKTTLLDLLSGDRSPQGGKVKRGKTLRLGYLSQTVGELDDEDRVLESVKRLKEETKLATGREASASSLLEEFGFTGDKLVARIGDLSGGERRRLQFLRLLLAEPNVLILDEPTNDLDIDTLTVIEDYLDRWPGTLIVVSHDRYFLERITDYTYALLGDGSCVLLPGGVDEYLDRRARSKAAAGSRPGGAAVEASRSDAAAERQRKKDLARIEGQLEKVAAEIERLHATMAEAATDFARLAELDAQLRDAEARHERLEEAWLETAD
>NZ_CP019229.1|WP_153302420.1|2702509_2703265_-|DUF4191-domain-containing-protein
MASEKAKALAAKQKAELKAAKLAKKNSTNPADWGWWRQLRETYRITVQYDTVLPWLMLAGFVVPFVALLILGIVLDAWIVWGIVGISAGVLGALSVFTWRARKAVYRRFDGQAGSAEVALQMLPKKWISTPVITATRQLDAVHRTLGPGGLVLIGEGDPGRLKPLLASEKKKHEQVAYGVDVIIVQMGKGSGQIPLDKLADHIKKLPNKLSAAKITEVNQRLRALDAMRPKAPIPRGPIQMKGARSAMRGR
>NZ_CP019229.1|WP_078920206.1|2703269_2704214_-|lipoyl-synthase
MTAVQPDGRRLLRVEAKNAETPIERKPSWIRTTAKMGPNYSDLQNIVRDGDLHTVCQEAGCPNIYECWEDRESTFLIGGDQCTRRCDFCQIESAKPEGYDPSEPLRVAASVRKMGLRYATVTGVCRDDLPDEGAWLYAETIRQIHAVNPGVGVEMLAPDFSGKAELLNQLFDARPEVFAHNVETVPRIFKRIRPGFRYDRSLRVLTMSREAGLVTKSNLILGMGETREEISQALRDLYDAGAELITITQYLRPNATLHPIDRWVTPEEFEDLAEEARGIGYSGVLSGPLVRSSYRAGRLYRTAMDARKMKVETE
>NZ_CP019229.1|WP_078920207.1|2704272_2705226_+|EamA-family-transporter
MLRPATPQTSGLLLLVVAGVAWGTSGTLGTLLNRASGLGFLPVAGYRILIGGLLLLAAAGFTGRVRLPRHRSGRRRVLAMAACAAVYQFGFFSAVGLLGVSIATLVTVGSAPVLVLMVDLVTGRQRLTRRLGLALVCTAIGLLLFMGTPPDGVTTAAALRGGALALLAGAAFAAISLLGARPERDYDDATGSGLAFLLGGAVVLGVALATGERVTIDPAPGAVALVVALGLIPSAVAYLAYLRGLRTQSSTTGVMVALLEPLTGAALAFLVLGERLGPTGLVGAVLLLAAVVLASLRPGVPAHAGERLSRAAGSAPG
>NZ_CP019229.1|WP_068749411.1|2705194_2705836_-|lipoyl(octanoyl)-transferase-LipB
MVAFEYRGLGEYHADYEETWQRQRELHEAVAAGAPGRIIYVEHAPVYTAGRRTTPEQRPQDGTPVIDVDRGGLITYHGPGQLVGYPIVRLRDGVGVVDYVRALESAVIDLLAGYGLETGRVDGRTGVWLPAGAGRPERKICAIGVRVARRTTMHGFALNVLSSAERFGNIIPCGIADAGVTSIVEELGGDWTVTGVADDLRDPLTRALTPLLD
>NZ_CP019229.1|WP_068749410.1|2705858_2706602_-|DUF554-domain-containing-protein
MAGVFIGAGTVVNVITVVVGSLIGIALGNRIPETTKSTVTAVLGLVTLVLGGMSVVAMNSEALREAVDGAAMLVVLAALLVGALLGSWLRVEDRLEQGAGWVRARFTASGDAARFVDGMVTATLLFCVGPLAILGSLSDGLGRGADQLLVKSVLDGFAAMAFASTLGWGVLASAGAVALIQGSLTAVGYFAGDVLTTAQVDALTATGGVVLLALGLRLLDLKQIPVGDLLPALLLAPPLVTLAAALI
>NZ_CP019229.1|WP_068749409.1|2706704_2707427_+|CPBP-family-intramembrane-metalloprotease
MRRFLAEPRAFLAAALLHPVERTRVETPGQRLRRRVVVALTIVAGAVALGFALAIPPGQSEFYLATVGVAALWVVGALASGPLYLGEGRARDGGRSRGVVQGVLLGLMLLGVFLAGALVVDRIPLLAGPVDDLLDHARFGSLWVVALITAVNGIAEELFFRGAVYASLPRSVNGIGSTALYAASTLFTGVPLLTFAAICLGLLTAAQRRVTGGVLGPIASHLTWSLGMLFLLPPTLALGG
>NZ_CP019229.1|WP_068749408.1|2707428_2708472_+|NAD(P)H-binding-protein
MPRTALVTGATGYIGAALAPVLLDDGWHVRVLARSPHKLDPAWRDRVEVVTGDAGDFADVVRALTGADVAYYLLHSMDGKGDYRARDRELAATFAEAARDAAVGRIVYLSGLHPRGPLSDHLASRVEVGEILLGSGVPTAVLQAGVVLGAGSASFDMLRHLTERLPVAVGPRWLRNRIQPIAVDDVLFYLRSAADLPPEVNRTIDVGMDERMTYIDMMRRYAQVTGLRPRHIWTLPVLTPGLASHWVGLVTPVDAGIARPLVGSLIHDAVKDDDDARALLGEPPGGTVGFDEAVRRATAGIDPHWWSRTLRGGVAAFGLSAGLAVVSTILSVTIARLVRDRRRGKAA
>NZ_CP019229.1|WP_068749407.1|2708468_2709194_+|methyltransferase-domain-containing-protein
MIDDLLTQAFDRGAKRYDLLVALNPGYHRELRRAAEALIGRLGDREGLRLLDLACGSGASTQALLSASPPGTEIHGLDASRGMLAQARAKHWPRRVTFDQARAGEIDLDRIDGGRDGILTCYLFRNVPEGDRDRAVAEVFALLRPGGWLVVQEYSVAGDPAAAFVWDAVSRGVIIPLGSVLDGGPELYRYLRRSVHDFDSVDRFMQRLAAAGFVDIAHRTAAGWQRGILHTFVAHKPEEHA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP019229_6	6.2\|1855711\|25\|NZ_CP019229\|CRISPRCasFinder	1855711-1855735	25	NZ_CP019229.1	2530132-2530156	1	0.96
NZ_CP019229_7	7.1\|2030756\|30\|NZ_CP019229\|CRISPRCasFinder	2030756-2030785	30	NZ_CP019229.1	1625580-1625609	2	0.933

1. spacer 6.2|1855711|25|NZ_CP019229|CRISPRCasFinder matches to position: 2530132-2530156, mismatch: 1, identity: 0.96

acggttcaggcgcgacctcagcgag	CRISPR spacer
acggtgcaggcgcgacctcagcgag	Protospacer
***** *******************

2. spacer 7.1|2030756|30|NZ_CP019229|CRISPRCasFinder matches to position: 1625580-1625609, mismatch: 2, identity: 0.933

tcgcgacgggggggcaggcgtcaggacggg	CRISPR spacer
tcgggacgggggggcaggcgtccggacggg	Protospacer
*** ****************** *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019229_4	4.1\|1698912\|25\|NZ_CP019229\|PILER-CR	1698912-1698936	25	NC_048068	Microbacterium phage OneinaGillian, complete genome	23624-23648	3	0.88
NZ_CP019229_4	4.1\|1698912\|25\|NZ_CP019229\|PILER-CR	1698912-1698936	25	MT310894	Microbacterium phage Tempo, complete genome	24004-24028	3	0.88
NZ_CP019229_4	4.1\|1698912\|25\|NZ_CP019229\|PILER-CR	1698912-1698936	25	NZ_CP021357	Rhodococcus sp. S2-17 plasmid pRB11, complete sequence	42188-42212	3	0.88
NZ_CP019229_4	4.1\|1698912\|25\|NZ_CP019229\|PILER-CR	1698912-1698936	25	NZ_LR134446	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence	28569-28593	4	0.84
NZ_CP019229_4	4.1\|1698912\|25\|NZ_CP019229\|PILER-CR	1698912-1698936	25	MT553342	Microbacterium phage Kelcole, complete genome	23977-24001	4	0.84
NZ_CP019229_3	3.2\|1282766\|27\|NZ_CP019229\|CRISPRCasFinder	1282766-1282792	27	NZ_CP047899	Pseudarthrobacter sp. YJ56 plasmid unnamed1, complete sequence	85851-85877	5	0.815
NZ_CP019229_6	6.2\|1855711\|25\|NZ_CP019229\|CRISPRCasFinder	1855711-1855735	25	NC_019959	Mycobacterium sp. JS623 plasmid pMYCSM03, complete sequence	47222-47246	5	0.8
NZ_CP019229_7	7.1\|2030756\|30\|NZ_CP019229\|CRISPRCasFinder	2030756-2030785	30	NZ_CP038237	Leisingera sp. NJS201 plasmid unnamed3, complete sequence	113653-113682	8	0.733
NZ_CP019229_7	7.1\|2030756\|30\|NZ_CP019229\|CRISPRCasFinder	2030756-2030785	30	NZ_CP035418	Leisingera sp. NJS204 plasmid unnamed1, complete sequence	17582-17611	8	0.733

1. spacer 4.1|1698912|25|NZ_CP019229|PILER-CR matches to NC_048068 (Microbacterium phage OneinaGillian, complete genome) position: , mismatch: 3, identity: 0.88

agcaccccgctcgcagcggtcgcgc	CRISPR spacer
gacaccccgctcgcagcgctcgcgc	Protospacer
..**************** ******

2. spacer 4.1|1698912|25|NZ_CP019229|PILER-CR matches to MT310894 (Microbacterium phage Tempo, complete genome) position: , mismatch: 3, identity: 0.88

agcaccccgctcgcagcggtcgcgc	CRISPR spacer
gacaccccgctcgcagcgctcgcgc	Protospacer
..**************** ******

3. spacer 4.1|1698912|25|NZ_CP019229|PILER-CR matches to NZ_CP021357 (Rhodococcus sp. S2-17 plasmid pRB11, complete sequence) position: , mismatch: 3, identity: 0.88

agcaccccgctcgcagcggtcgcgc	CRISPR spacer
accagcccgctcgcagcggtcgccc	Protospacer
* ** ****************** *

4. spacer 4.1|1698912|25|NZ_CP019229|PILER-CR matches to NZ_LR134446 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence) position: , mismatch: 4, identity: 0.84

agcaccccgctcgcagcggtcgcgc	CRISPR spacer
gacgccccgctcgccgcggtcgcgc	Protospacer
..*.********** **********

5. spacer 4.1|1698912|25|NZ_CP019229|PILER-CR matches to MT553342 (Microbacterium phage Kelcole, complete genome) position: , mismatch: 4, identity: 0.84

agcaccccgctcgcagcggtcgcgc	CRISPR spacer
gacaccccgctcgcagcactcgcgc	Protospacer
..***************. ******

6. spacer 3.2|1282766|27|NZ_CP019229|CRISPRCasFinder matches to NZ_CP047899 (Pseudarthrobacter sp. YJ56 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

cgcgacggagggctggcgccacgacgg	CRISPR spacer
ccggcgggagggctggcgcctcgacgg	Protospacer
*  *  ************** ******

7. spacer 6.2|1855711|25|NZ_CP019229|CRISPRCasFinder matches to NC_019959 (Mycobacterium sp. JS623 plasmid pMYCSM03, complete sequence) position: , mismatch: 5, identity: 0.8

acggttcaggcgcgacctcagcgag	CRISPR spacer
gtggttccggcgcgacctcagcgcc	Protospacer
..***** ***************

8. spacer 7.1|2030756|30|NZ_CP019229|CRISPRCasFinder matches to NZ_CP038237 (Leisingera sp. NJS201 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.733

tcgcgacgggggggcaggcgtcaggacggg	CRISPR spacer
cagcgacggggtggcaggcgtcaaggtgct	Protospacer
. ********* ***********.*..*

9. spacer 7.1|2030756|30|NZ_CP019229|CRISPRCasFinder matches to NZ_CP035418 (Leisingera sp. NJS204 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tcgcgacgggggggcaggcgtcaggacggg	CRISPR spacer
cagcgacggggtggcaggcgtcaaggtgct	Protospacer
. ********* ***********.*..*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

547464 : 610177

Streptococcus_phage(22.22%)

integrase,transposase

attL 567609:567626|attR 611423:611440

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_078919609.1\|547464_548751_+\|integrase	tyrosine-type recombinase/integrase	A0A2P1N210	Mycobacterium_phage	3.9e-39	34.3
WP_078919610.1\|549180_549711_+	SigE family RNA polymerase sigma factor	NA	NA	NA	NA
WP_153302362.1\|549707_550712_+	hypothetical protein	NA	NA	NA	NA
WP_078919578.1\|551236_552475_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_078919613.1\|553204_553450_-	hypothetical protein	NA	NA	NA	NA
WP_077344285.1\|553572_554139_-	hypothetical protein	NA	NA	NA	NA
WP_153302363.1\|554435_554633_-	DNA-binding protein	NA	NA	NA	NA
WP_153302364.1\|554638_554986_-	hypothetical protein	NA	NA	NA	NA
WP_078919615.1\|555589_556816_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	6.7e-105	51.4
WP_078919616.1\|557008_559084_+	SAM-dependent DNA methyltransferase	A0A220A2U4	Liberibacter_phage	2.8e-31	27.4
WP_078919617.1\|559080_560280_+	hypothetical protein	NA	NA	NA	NA
WP_153302365.1\|563496_564228_+	hypothetical protein	NA	NA	NA	NA
WP_153302366.1\|564278_565031_-	hypothetical protein	NA	NA	NA	NA
WP_078919620.1\|565020_570837_+	relaxase domain-containing protein	NA	NA	NA	NA
567609:567626	attL	NA	NA	NA	NA
WP_078919621.1\|570911_571541_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_078919622.1\|571540_571978_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_078919623.1\|571974_572841_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_078919624.1\|572910_573678_+	hypothetical protein	NA	NA	NA	NA
WP_078919625.1\|573750_574455_+	DUF3800 domain-containing protein	NA	NA	NA	NA
WP_078919626.1\|574617_575460_-	hypothetical protein	NA	NA	NA	NA
WP_078919627.1\|575709_576426_-	hypothetical protein	NA	NA	NA	NA
WP_078919628.1\|576582_577371_-	nucleotide-binding protein	NA	NA	NA	NA
WP_078919629.1\|577484_578528_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_078919630.1\|578520_578853_-	hypothetical protein	NA	NA	NA	NA
WP_073186963.1\|579147_580272_+	beta-propeller fold lactonase family protein	NA	NA	NA	NA
WP_078919631.1\|580544_581921_-	mercury(II) reductase	A0A2K5B2C5	Erysipelothrix_phage	1.3e-35	27.0
WP_078919632.1\|582015_582405_+	heavy metal-responsive transcriptional regulator	NA	NA	NA	NA
WP_153302367.1\|582662_583214_+	hypothetical protein	NA	NA	NA	NA
WP_153302446.1\|583339_584671_+	4Fe-4S binding protein	NA	NA	NA	NA
WP_078919635.1\|584738_588275_+	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
WP_078919636.1\|588456_588717_+	SHOCT domain-containing protein	NA	NA	NA	NA
WP_153302447.1\|588926_589448_+	hypothetical protein	NA	NA	NA	NA
WP_153302448.1\|589450_590170_+	response regulator transcription factor	NA	NA	NA	NA
WP_078919638.1\|590166_591336_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_078919639.1\|591585_591798_+	hypothetical protein	NA	NA	NA	NA
WP_078919640.1\|591982_592597_-	hypothetical protein	NA	NA	NA	NA
WP_078919641.1\|592794_593208_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_078919642.1\|593204_595202_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.4e-99	38.2
WP_078919643.1\|595198_596113_+	cation transporter	NA	NA	NA	NA
WP_139280155.1\|596322_596850_+	redoxin domain-containing protein	NA	NA	NA	NA
WP_078919644.1\|596846_597599_+	cytochrome C biogenesis protein ResC	NA	NA	NA	NA
WP_078919645.1\|598238_598859_-	peroxiredoxin family protein	NA	NA	NA	NA
WP_078919646.1\|598855_599821_-	cytochrome C biogenesis protein	NA	NA	NA	NA
WP_078920401.1\|599820_600078_-	hypothetical protein	NA	NA	NA	NA
WP_078919647.1\|600246_600954_+	response regulator transcription factor	NA	NA	NA	NA
WP_078919648.1\|600950_602090_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	3.6e-20	25.8
WP_078919649.1\|602178_602826_+	DUF305 domain-containing protein	NA	NA	NA	NA
WP_073186966.1\|602926_603109_-	hypothetical protein	NA	NA	NA	NA
WP_078919650.1\|603692_604490_-	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
WP_078919651.1\|605123_607532_+	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	7.7e-81	33.3
WP_078919652.1\|607622_608489_+	DMT family transporter	NA	NA	NA	NA
WP_153302449.1\|608723_608867_+	heavy metal transporter	NA	NA	NA	NA
WP_153302368.1\|608879_609857_-\|transposase	IS3 family transposase	A0A160DCU2	Gordonia_phage	2.7e-69	45.9
WP_153302369.1\|609853_610177_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	6.8e-17	48.1
611423:611440	attR	NA	NA	NA	NA

DBSCAN-SWA_2

2355344 : 2404911

Pandoravirus(14.29%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068750123.1\|2355344_2356292_+\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_068750125.1\|2356302_2356854_+	hypoxanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_078920477.1\|2357000_2358983_+\|protease	ATP-dependent zinc metalloprotease FtsH	A0A0P0CCN8	Ostreococcus_mediterraneus_virus	3.7e-105	41.6
WP_068750129.1\|2358984_2359551_+	GTP cyclohydrolase I FolE	A0A172Q012	Pseudomonas_phage	5.7e-43	53.4
WP_068750217.1\|2359567_2360365_+	dihydropteroate synthase	S4VNV0	Pandoravirus	8.9e-18	30.2
WP_078920086.1\|2360361_2360787_+	dihydroneopterin aldolase	NA	NA	NA	NA
WP_068750131.1\|2360779_2361343_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_078920087.1\|2361213_2361834_+	DUF3180 domain-containing protein	NA	NA	NA	NA
WP_068750134.1\|2361891_2362494_+	hypothetical protein	NA	NA	NA	NA
WP_068750136.1\|2362514_2363615_-	NADH-quinone oxidoreductase subunit D	NA	NA	NA	NA
WP_068750138.1\|2363697_2364018_+	Lsr2 family protein	S5W0B7	Mycobacterium_phage	4.4e-16	46.3
WP_068750140.1\|2364138_2366649_+\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A1S6UBG5	Serratia_phage	3.8e-131	41.6
WP_078920088.1\|2366712_2367165_-	DUF202 domain-containing protein	NA	NA	NA	NA
WP_068750143.1\|2367038_2367401_-	DUF202 domain-containing protein	NA	NA	NA	NA
WP_068750145.1\|2367469_2368144_+	CDP-alcohol phosphatidyltransferase family protein	NA	NA	NA	NA
WP_068750147.1\|2368174_2369149_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.3e-20	33.9
WP_068750149.1\|2369142_2370807_-	iron ABC transporter permease	NA	NA	NA	NA
WP_068750151.1\|2370785_2371838_-	thiamine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_078920089.1\|2372023_2373067_-	DNA integrity scanning protein DisA	NA	NA	NA	NA
WP_078920090.1\|2373098_2374775_-	AarF/ABC1/UbiB kinase family protein	A0A2N9QVT9	Dishui_lake_phycodnavirus	6.9e-36	34.0
WP_078920091.1\|2374908_2375664_+	hypothetical protein	NA	NA	NA	NA
WP_068750157.1\|2375618_2376731_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_068750159.1\|2376733_2378116_-	DNA repair protein RadA	NA	NA	NA	NA
WP_068750161.1\|2378147_2378786_-	VOC family protein	NA	NA	NA	NA
WP_068750163.1\|2378872_2379685_+	sugar phosphate isomerase/epimerase	NA	NA	NA	NA
WP_141680007.1\|2379671_2380580_+	hypothetical protein	NA	NA	NA	NA
WP_068750167.1\|2380576_2381341_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_078920092.1\|2381345_2381702_-	hypothetical protein	NA	NA	NA	NA
WP_068750171.1\|2381698_2382124_-	hypothetical protein	NA	NA	NA	NA
WP_068750172.1\|2382114_2382654_-	universal stress protein	NA	NA	NA	NA
WP_141680009.1\|2382712_2383741_+	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_068750176.1\|2383737_2384529_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.7e-21	31.8
WP_042842924.1\|2384635_2384737_+	AURKAIP1/COX24 domain-containing protein	NA	NA	NA	NA
WP_068750179.1\|2384736_2385036_+	glutaredoxin family protein	NA	NA	NA	NA
WP_078920093.1\|2384962_2386648_+	bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_078920478.1\|2386685_2387315_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_068750182.1\|2387311_2387863_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_068750226.1\|2387904_2388615_+	cytochrome C biogenesis protein ResC	NA	NA	NA	NA
WP_141680010.1\|2388656_2390171_+	cytochrome c biogenesis protein ResB	NA	NA	NA	NA
WP_068750186.1\|2390167_2391079_+	c-type cytochrome biogenesis protein CcsB	NA	NA	NA	NA
WP_068750188.1\|2391082_2392525_+	hypothetical protein	NA	NA	NA	NA
WP_068750190.1\|2392521_2393283_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_068750192.1\|2393360_2394767_+	mycothione reductase	A0A2K5B2C5	Erysipelothrix_phage	1.4e-37	27.3
WP_068750194.1\|2394763_2395972_+	glycoside hydrolase family 3 protein	NA	NA	NA	NA
WP_068750196.1\|2396023_2396902_+	hypothetical protein	NA	NA	NA	NA
WP_068750198.1\|2396908_2397688_-	phosphate ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.6e-11	31.7
WP_068750200.1\|2397706_2398774_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_068750202.1\|2398773_2399766_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_068750203.1\|2399870_2400980_-	phosphate ABC transporter substrate-binding protein PstS	A0A0B5JDE8	Pandoravirus	6.8e-08	28.3
WP_141680008.1\|2401508_2402654_-\|transposase	IS3 family transposase	A0A160DCU2	Gordonia_phage	2.5e-69	45.9
WP_068750209.1\|2402482_2402806_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.5e-16	47.6
WP_068751155.1\|2403651_2404911_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	4.4e-11	31.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019229

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection