CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018756	Stenotrophomonas maltophilia strain AA1 chromosome, complete genome	30 crisprs	WYL,DEDDh,csa3,cas3,Cas9_archaeal,DinG	2	5	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018756_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_1

279333-279431

Orphan

Consensus_repeat	Method
GTCACCACCAACGGTGGTGACCTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_1

>merge|NZ_CP018756|1|279333-279431|CRISPRCasFinder
GTCACCACCAACGGTGGTGACCTACCCAAATGCAGAACGCGGGTACCGACCGTTGGTCGGTACGCCTCAAAGCGTCACCACCAACGGTGGTGACCTACC

>NZ_CP018756|1|1|279333-279431|CRISPRCasFinder
GTCACCACCAACGGTGGTGACCTACC	CAAATGCAGAACGCGGGTACCGACCGTTGGTCGGTACGCCTCAAAGC
GTCACCACCAACGGTGGTGACCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079220596.1\|270876_272067_+\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235406
NZ_CP018756.1\|WP_152027036.1\|288170_288908_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079220597.1\|272100_272466_-\|type-1-fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NZ_CP018756.1\|WP_079220605.1\|282047_283301_+\|serine-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234571
NZ_CP018756.1\|WP_079220593.1\|266238_268449_+\|type-II-secretion-system-secretin-GspD	unknown	unknown	gnl\|CDD\|274175
NZ_CP018756.1\|WP_079220595.1\|269946_270786_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NZ_CP018756.1\|WP_152027035.1\|283384_283819_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224213
NZ_CP018756.1\|WP_079220598.1\|272898_273447_+\|ferrous-iron-transporter-B	unknown	unknown	gnl\|CDD\|226069
NZ_CP018756.1\|WP_079220602.1\|277992_279309_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP018756.1\|WP_079220603.1\|279471_281136_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_CP018756.1\|WP_079220594.1\|269095_269950_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NZ_CP018756.1\|WP_079220601.1\|276895_277930_+\|fimbrial-protein	unknown	unknown	gnl\|CDD\|226069
NZ_CP018756.1\|WP_079220608.1\|284546_285632_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	unknown	unknown	gnl\|CDD\|182729
NZ_CP018756.1\|WP_079220600.1\|274280_276905_+\|fimbrial-biogenesis-outer-membrane-usher-protein	unknown	unknown	gnl\|CDD\|225729
NZ_CP018756.1\|WP_079220612.1\|288961_289585_-\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|275096
NZ_CP018756.1\|WP_079220599.1\|273521_274247_+\|fimbria/pilus-periplasmic-chaperone	unknown	unknown	gnl\|CDD\|236634
NZ_CP018756.1\|WP_079220604.1\|281389_281869_+\|RcnB-family-protein	unknown	unknown	gnl\|CDD\|378715
NZ_CP018756.1\|WP_079220609.1\|286150_287062_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079220610.1\|287190_288069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079220607.1\|283913_284435_+\|transcriptional-repressor-NrdR	unknown	unknown	gnl\|CDD\|234774

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079220596.1\|270876_272067_+\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|235406	PRK05321, PRK05321, nicotinate phosphoribosyltransferase; Provisional.	0
NZ_CP018756.1\|WP_079220597.1\|272100_272466_-\|type-1-fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	6.40256e-05
NZ_CP018756.1\|WP_079220605.1\|282047_283301_+\|serine-hydroxymethyltransferase	gnl\|CDD\|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NZ_CP018756.1\|WP_079220593.1\|266238_268449_+\|type-II-secretion-system-secretin-GspD	gnl\|CDD\|274175	TIGR02517, Putative_type_II_secretion_system_protein_D, type II secretion system protein D. In Gram-negative bacteria, proteins that have first crossed the inner member by Sec-dependent protein transport can be exported across the outer membrane by type II secretion, also called the main terminal branch of the general secretion pathway. Members of this family are general secretion pathway protein D. In Yersinia enterocolitica, a second member of this family is part of a novel second type II secretion system specifically associated with virulence (See ). This family is closely homologous to the type IV pilus outer membrane secretin PilQ (TIGR02515) and to the type III secretion system pore YscC/HrcC (TIGR02516). [Protein fate, Protein and peptide secretion and trafficking].	5.94137e-170
NZ_CP018756.1\|WP_079220595.1\|269946_270786_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	4.40041e-52
NZ_CP018756.1\|WP_152027035.1\|283384_283819_+\|hypothetical-protein	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	0.0055037
NZ_CP018756.1\|WP_079220598.1\|272898_273447_+\|ferrous-iron-transporter-B	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	1.3838e-17
NZ_CP018756.1\|WP_079220602.1\|277992_279309_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	2.56603e-168
NZ_CP018756.1\|WP_079220603.1\|279471_281136_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP018756.1\|WP_079220594.1\|269095_269950_+\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.03092e-05
NZ_CP018756.1\|WP_079220601.1\|276895_277930_+\|fimbrial-protein	gnl\|CDD\|226069	COG3539, FimA, P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion].	1.72376e-21
NZ_CP018756.1\|WP_079220608.1\|284546_285632_+\|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD	gnl\|CDD\|182729	PRK10786, ribD, bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD.	2.11215e-132
NZ_CP018756.1\|WP_079220600.1\|274280_276905_+\|fimbrial-biogenesis-outer-membrane-usher-protein	gnl\|CDD\|225729	COG3188, FimD, P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_CP018756.1\|WP_079220612.1\|288961_289585_-\|outer-membrane-beta-barrel-protein	gnl\|CDD\|275096	TIGR04273, activator_of_XA21-mediated_immunity_Ax21, sulfation-dependent quorum factor, Ax21 family. This family consists of proteins closely related to Ax21 (Activator of XA21-mediated immunity), a protein that is secreted by a type I secretion system (RaxABC), and that appears to be sulfated on an N-terminal region tryosine in a motif LSYN. Ax21 acts in a quorum-sensing system. Homologous peptide-mediated quorum-sensing systems appear to exist in other species, such as the emerging opportunistic pathogen Stenotrophomonas maltophilia. Intriguingly, the rice genome encodes a receptor (XA21) for this protein that triggers innate immunity. [Cellular processes, Pathogenesis].	2.87875e-21
NZ_CP018756.1\|WP_079220599.1\|273521_274247_+\|fimbria/pilus-periplasmic-chaperone	gnl\|CDD\|236634	PRK09926, PRK09926, fimbrial chaperone.	9.68926e-81
NZ_CP018756.1\|WP_079220604.1\|281389_281869_+\|RcnB-family-protein	gnl\|CDD\|378715	pfam11776, RcnB, Nickel/cobalt transporter regulator. RcnB is a family of Proteobacteria proteins. RcnB is required for maintaining metal ion homeostasis, in conjunction with the efflux pump RcnA, family NicO, pfam03824.	2.50158e-11
NZ_CP018756.1\|WP_079220607.1\|283913_284435_+\|transcriptional-repressor-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	2.78734e-85

>NZ_CP018756.1|WP_079220602.1|277992_279309_-|NCS2-family-permease
MSLFERLFQLQQHGTTVRTELLAGVTTFLTMSYIVFVNPEILGTTGMDAGAVFVATCLAAALGSAVMALAANFPVGMAPGMGLNAFFAFTVVGAAGLPWQQALGAVFISGLVFLVLSLTGVRAWLVAGIPSSLRSAIVAGIGLFLAIIALQKSGVIVGNEDTLVALGPLNTAPPLLALGGFLLIAVLEARRVRGAILIGILAVTGAGWALGDVQYHGLVSLPPSLAPTFLQLDLPGLLHHDGGAPIAVLLQVVLVFVLVEVFDATGTLYGVVGRAGLLKLPGAQKRFGRALLADSTAIVAGSLLGTSSTTAFAESASGVQVGGRTGLTALVVSALFLAALLFSPLAAMVPAYATSPALLFVAGLMLRELVEVDWSDLTESVPAALCALAMPFTYSIANGLAFGFIAYAALKAGTGRWREVHPAVWLVATLFVLRYALE
>NZ_CP018756.1|WP_079220601.1|276895_277930_+|fimbrial-protein
MPLMSFRRGTLVMALLAAGTGLSGQALAACSIDTRGFIAQDVEMDMGQVVILPTTPVGGVIKQLSVPIIARNSVASCDWWAGGRSVGVYFNAAQQRLSPGYSNVYQTGVEGVGIRLYRDSGAIQTYYPHQISYSAGSTISLVAGQFKIELIKTAAVTGSGIIAPNGRFTNYYFDGDGAGRPVLTSSFKGSGTTVVSPTCEVDAGSRNIVVDFGSVPNDSFTGVGSRAVDRDFNINLRCQGSNVAQYQSTIGIQLDATSASGNQPGTLALTSGSNSATRIGIQIVRRNGSNEQTIRFGDSLMLGDTVTGSSTMSLPLRARYIQTQAGTVGPGEANGTATFTITYN
>NZ_CP018756.1|WP_079220600.1|274280_276905_+|fimbrial-biogenesis-outer-membrane-usher-protein
MAAPRPSSRNVSVIGNRLTLSIRQAVCLLAAGAASPGWAVAAPANLGEQALMAQSTAATAAPPEQAQFNSSFLSGKAGQVDLAAFANGNPMVAGSYRVDVYVNGAWQGRRDVEFKADAQGKVDACLGLPMLEEFGVDSEAVLAQQDPAVPTAADACVPVQQRMANAFGTFDSGSLRYDLSIPQVFLRRHARGYVNPALWDRGINAGFLGYTFNAVDSQTRTEGGGRNRTAYLGLNSGINLGGWQLRHDSNLTWSDGNGRHWQSIATYAQRGIAQVRGMLTVGEAFTSGELFDSIAYRGASLATDDRMLPDSLRGYAPVVRGIAETNARVEVRQSQQLIYSTTVSPGSFVIDDLYPTGYGGDLEVSVIEADGRRRTFSVPFGSVPQMLRAGVSRYAVTAGQVRNDLLRDDPWLLQGTWQRGIDNRVTVYGGSALSTGYVSLLYGAGVSTPVGAFAADVTHARTRLDTLGERSGASVRLSYSNLIGETNTNLTLAAYRYSTGGFYSLQDALMVRDDISRGNDPSVRGRQRSQFQVTLNQPLGLRGGSLYVTGALRDFYDRPGTSKQYQVGYNNAWRSLNFGVSAIRTEEGLAGTADTQYLLSMSVPLGQGRRQPMSFSADVGVRDRSGYDSSRIGITGSAGSDNELSYGVALSDSREGGTTGIANAEYRSRYAATSASYGYSSAFRQLAVGATGSLVVHGGGVTLSPQRGDTLVLVQAAGARDARVANAPGLRIDGRGYAVVPYVSPYRLNTITLDPQGMSLDVELEGSSQSIAPYAGAISLLRFETRQGRALLIQAHGADGSTLPFGAQVKDAQGQPVGMVGQGGRVYVRTADDSGQLQVEWGDDADARCTIDYTAPASADAGPAGLTTVEALCR
>NZ_CP018756.1|WP_079220599.1|273521_274247_+|fimbria/pilus-periplasmic-chaperone
MKAFLSRTLLTAAFSLALCQTALAGVVINGTRVIYPGQAREVTVQVDNVGDSPSLVQAWIDSGDANQTADSSDAPFVLTPPISRVEPGRSQALRVMFTGAKLPTDRETVFWFNVLDVPPSPARTGDADQNMLQVAFRSRLKLFYRPQGLPGTANEAPALLRWSRSGDRLRVENPSAYHVTLAEVHALAGTRDEVVEDKGKMAAPGQSIEFTVPAATTQVRFITINDFGGRVERTVDLARGN
>NZ_CP018756.1|WP_079220598.1|272898_273447_+|ferrous-iron-transporter-B
MRKINLFAVLLLAAAPLAANAADGTITFKGKVTDVTCQITTPAGKDFTVNLPTVSKASLATVGATNGRTQFAINLSKCGTNSNVATYFEPGSTVDFATGRLLNQTPTSANGAGNVQVQLLGSNFDVLPIKAASSGLAQTNSQWVNTGTAGTADLNYYAEYYATGAASAGEVSTSVKYTIIYN
>NZ_CP018756.1|WP_079220597.1|272100_272466_-|type-1-fimbrial-protein
MKTSILLCVALMGVSSLAHADGGTIRFSGRIVDPGCSARVDQQQLRLEGCPLSAKGATVALVAMEEGQGAVLRDGKRQGQQLAVAARSLRAGDLVFSESYRLEAPKQQPLQGAYLVRVDYP
>NZ_CP018756.1|WP_079220596.1|270876_272067_+|nicotinate-phosphoribosyltransferase
MAIIQSLLDTDLYKFTMMQAVLHQHPGALVQYRFKCRTPGIDLASYIDQINEEIDHLCSLRFTSEELDYMRGLRFVKPDFADFLGLFHLDRKYIQLQPSKTVPGEIDLDITGPWLHTILFEVPLLAIINEVWFRNTTTADFAEGERRLQAKAALLRDTPGFEQCRIADYGSRRRYSRDWHARLLPLLRDALGPQLVGTSNVHFARLYGMTPHGTMAHEYLQAFQALGPRLRDSQVAALESWAREYRGDLGIALSDVVGLDAFLRDFDMYFCKLFDGVRHDSGDPFDWGDRMLAHFQQRRVDPRSKVLVFSDGLDITKVMRLYDYFRGRCQVAFGVGTHLTNDLGPTPLNIVIKMVRCNGQPVAKLSDSPGKSMCDDPGYLSYLRQVFELPPEVPQG
>NZ_CP018756.1|WP_079220595.1|269946_270786_+|glycosyltransferase-family-2-protein
MNPAIAAIVVTYQSGSTIDACLSRLRQAQDVAQIRVVDNGSQDDTLEIVQRHASHDPRVRFIGNPDNPGFAAANNQGVADSSSPWLAFINPDLLVEEDTLAALRDRALVLGDCLLGVEQVDEHGFADEAVRRRDPDFLAMLRSPGRGGRLAIPRDPAQALQRVPALSGALLLMSRALFDRIGGWDAGYRLHAEDLDLCRRVRDAGGVVAIANDLRVTHVRGVSSRSRPFFVEWHKHRGLWRYFSKFEAKQRSAPVRVMVWGAIWAHALMLVPRLLRKSL
>NZ_CP018756.1|WP_079220594.1|269095_269950_+|glycosyltransferase
MGAIVLLPLGVDDAALDRCLAALDAGTAAGTAVWLADDAQAGPRAQAVVEHWLAQTPLQAEYTRRARPLGEVAHLDEMLRACEGLDVAVLAPDSVPAPGWLQQLQAAFARDAAIATATPWCNAGETAAWPRLGEINPEPADPALLAHTCASLPNLHPELPSAVTHAVLVRGNARRRAGGLDTDSYLGWNAALVDLSLRMAGLGWRNVLCENAFVSRAGEAASREGDLEALAARWPGWMPRLADFLMHDPLHALRDDLQQRLRQAIMPRDQGDLFAMPTPPESPA
>NZ_CP018756.1|WP_079220593.1|266238_268449_+|type-II-secretion-system-secretin-GspD
MNLRFLPWSLALTLLVGCATVSGPHVHRSATTPPPEAGAASADPQVVEGDAAAGTPQAVIRRGSGTMINREAARAPSPALHSASGGSATFNFEGESVHAVVKAILGDMLGQNYVIAPGVQGTVTLATPKPVSPAQALNLLEMVLGWNNARMVYSGGRYNIVAADQALAGTVAPSTAPASSARGFEVRVVPLQFISASEMKKVLEPYARPNAIVNVDTGRNVITLGGTRAELENYLHTVEIFDVDWLSGMSVGVFPIQSGKAEQVASDLEKVFGEDSKTPSAGMFRFLPLENANAVLVITPQVRYLDQIQQWLDRIDTAGGSARLFSYELRYIKARDLAQRLAEAFASSNSRNNRGSVPGLAPGAMPMQLDSRGGNSSNSDIVDVGSNNGTGTSNANGGMTSTMNLPQRQEGNISVSLDVEGDTVGVSAVEETNALLVRATPQAWRSIREVIEKLDVMPLQVHIEAQVAEVDLTGDLKYGVNWFFENAVQGQDFSGSTGGATLPSALGRNIWGSFAGAITGSETGWTFLGKNAAAVVSALDKVTNLRLLQTPSIFVRNNAEAQLNVGTKIPINSVSVNTGISDSTYSTVQYLDTGVILKVRPRITRDGVVFLDIVQEVSSAGAIPTGCDPTKTTCNPPINTRKISTEAALQSGDTIMLAGLITNSDEEGSSGVPGLSRLPIVGGLFGNKTRLNKRSEVIVLLTPTIVRNGQEARTLTDEYSNRFRAMEPFPTRERKK
>NZ_CP018756.1|WP_079220603.1|279471_281136_-|energy-dependent-translational-throttle-protein-EttA
MSSQYIYTMNRVSKVVPPKRQIIKDISLSFFPGAKIGLLGLNGAGKSTVLKIMAGVDTDFEGEARPQAGIKVGYLAQEPELDPTKTVREAVEEGVGEVLQAQAALDAVYTAYAEEGADFDALAKEQERLEAILAAGDAHTLENQLDVAADALRLPPWDAVVGKLSGGEKRRVALCRLLLQKPDMLLLDEPTNHLDAESVEWLEQFLARYTGTVVAVTHDRYFLDNAAEWILELDRGRGIPWKGNYTDWLTQKDERLKQEDNQEKARQKAIQKELEWSRQNAKGGRTKGKARLARLEELQSVDYQKRNETNEIFIPPGERLGNAVMEFKNVSKKFGDRLLFDNLSFLVPAGAIVGIIGPNGAGKSTLFKMITGQEKPDTGEIVVGPTVKLSYVDQSRDALEGNHNVFQEIAGGLDILNINGIEIQSRAYIGRFNFKGQDQQKMVGSLSGGERGRLHMAKTLLQGGNVLLLDEPSNDLDIETLRALEDALLEFPGNTFVISHDRWFLDRIATHILAFEGDSHVEFFQGNYREYEEDKRRRMGDDAAPKRLRFKALK
>NZ_CP018756.1|WP_079220604.1|281389_281869_+|RcnB-family-protein
MRINFIVAGAMASVLALGAVTPAFADNDHRDRREWREDRRDDRREYRHDVREARRDYERDRRDARRDWRRDHDRRYYHPAPPPPRVVYRPGYRPGPGYGWQVGHRYRDYYRGPIYVVNDYPRYHLRRPPYGHHWIRDDRGNMLLVAIATGVIAQYVLSR
>NZ_CP018756.1|WP_079220605.1|282047_283301_+|serine-hydroxymethyltransferase
MFPRDVRIETYDPELAKAIAAETQRQEDHVELIASENYTSPAVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAIDRLKQLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGAKVNASGKLFNAVQYGVNDQGLIDYDEVERLALEHKPKMVVAGFSAYSQVIDWARFRAIADKVGAYLFVDMAHVAGLVAAGVYPSPLEHAHVVTSTTHKTLRGPRGGIIVAKGADEDLVKKLQSVVFPGIQGGPLMHVIAAKAVAFKEALEPGFTAYQQQVVKNAQAMANTLIARGYKIVSGGTQNHLMLVDMIGKDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAVTTRGYVEQDCVDLANWIADVLDAPADDAVIARVRDAVSAQCRKYPVYG
>NZ_CP018756.1|WP_152027035.1|283384_283819_+|hypothetical-protein
MNERLHKRLHLVQALLFGLPGVLLGGTVALVGVYSGLMQETRLLSRLLLVCWGAAGALGIVAWLHIGAGFLLQGRPGLQAVGRLWWALLALGALAAVPAAVLGLVVGLTERMEGFGLLLFGPPLLLPAAHLAWLRWRQPLAAQG
>NZ_CP018756.1|WP_079220607.1|283913_284435_+|transcriptional-repressor-NrdR
MYCPFCQHADTRVIDSRVSEDGATIRRRRECEACNERFSTLETVELKLPAIVKSDGTREAFDQRKVRAGFDRALQKRAVPEEKIEAAVRAVVHQLRISGEREVPSIKVGEFVMNELRKLDHVGYVRFASVYRSFEDVADFREEIEKLERELPASTEQLQLLGDVIALTKKKKG
>NZ_CP018756.1|WP_079220608.1|284546_285632_+|bifunctional-diaminohydroxyphosphoribosylaminopyrimidine-deaminase/5-amino-6-(5-phosphoribosylamino)uracil-reductase-RibD
MSTPFTVLDHLHMANALRLAERAAYTTRPNPMVGCVIAHGERVVGQGWHQRAGGPHAEVFALREAGSEARGATAYVTLEPCAHYGRTPPCALALIDAGVSRVVAALRDPFPKVDGGGFNLLREAGIEVAEGLMAAQARELNKGFLSRVERNRPWLRVKLAASLDGRTAMADGSSKWITGAAAREDVQHWRACAGAILTGADTVLADDPMLTVRLADTEVMPPLRVVLDSRLRSLECSRVREDGAPTLYLHDAAVSAPDAADAEFASVPCVDGRLDLGAVLALLAERGINEVHTEAGATLAGALLRGGWVDELLLYQAPTLLGDNGRPLLAGLGINAMDQQRRLRVVDQRQVGEDIRLLLRP
>NZ_CP018756.1|WP_079220609.1|286150_287062_-|hypothetical-protein
MRRLLLCLLALGMHLPSATARGRTPEDVVSHHLQAMQERYDLALQTLVQQREAGQTGTTDIPVDAPPMAVLLATWTRNIERHVDRIDGVDLPHLAWALQVLANTRCQPHRSEVWHSLTEGIQVADVHFTCRVGDVERLRHLSEAAVFDGGEQSEQRFWRAYIATLRDGPFHEIGGTTRVVSTTHEPAWHSEKSRHPNEDFPSGRVERDIYELLTEALITQPRHLDRAGTHDAITQMTGIVACDDLLQQHRRCMARIAPQELKGVSELASTLSKQRQQIPEAELLQQCMALRPGMQAFWTAECR
>NZ_CP018756.1|WP_079220610.1|287190_288069_-|hypothetical-protein
MKTPLRTLLASTLLCAPVFATAAPALTPEQSLDLYARVLIEDDAAAARTLNDALRSAHDGKDAVTPTPGALAKALAEPWMALQASTGGTPDAAATEALYAKVLKASTCRATGSTIEDNEYVDGQKIASVDFSCKVVDLESVRPLFAASMTSDDPAARSRFIDAYTQALKSGTQRTVTGSQKLYSGAEQAYWFSGSFDELVTPVLEALAPFQLWMEDAQAASAPKVTGVPSCDLLLQQHRSCVAKIAPDQISGVDAMAEELKAKAQVKSADEMTQECKALRPIAEMMWTDECA
>NZ_CP018756.1|WP_152027036.1|288170_288908_-|hypothetical-protein
MRLSFQTNCMASCGLLPQAAVLSPSGWTMLAYRLPLLLCLPFAAQATASEKLSPEQAFDLYAQALLEGDARAAEALTRALPADALWNATALLRLPRLLQDTHEQVFDQWEDEVVPAVLAEAVVTQIGRTYASSHCRAVPGQTIAEAAPAGQAQITFTCQVPAWNTGSGLLADPAIQQKLQDDEVFAAYLIASELRMAEQQTITGTALLEGSAGTGYFPDGDTIRFLAPVLLSIFPETLADTLLEK
>NZ_CP018756.1|WP_079220612.1|288961_289585_-|outer-membrane-beta-barrel-protein
MRKILIVAALLAAAPFSASADGLSYTYVEGGWSQVNTKDDGFDDPKVDGGYVRGSFALAEQVHVFGGWSYGSKTYHYSNAKLKLELNQPELGIGYHMPFSDRVDYTADIAWVRQQAEVKADFDGFGRITDKDHTNLVRATMGLRGKPSAMTEAWIKAGYMDGGNNFEGTWVGTLGGQINFTKTWGLVGEISGYRDVTQFSAGVRASF

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Crispr_ID: NZ_CP018756_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_2

478713-478846

Orphan

Consensus_repeat	Method
CTGTTGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_2

>merge|NZ_CP018756|2|478713-478846|CRISPRCasFinder
CTGTTGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATCGAATGAATTCATCCACGCATGGCGTGGATCTACCGTTCGCCGCTGTTGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATCGA

>NZ_CP018756|2|2|478713-478846|CRISPRCasFinder
CTGTTGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATCGA	ATGAATTCATCCACGCATGGCGTGGATCTACCGTTCGCCG
CTGTTGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079220770.1\|485235_486222_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235468
NZ_CP018756.1\|WP_079220763.1\|473506_473890_+\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP018756.1\|WP_079220773.1\|489807_490311_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_049456418.1\|482529_484377_-\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NZ_CP018756.1\|WP_079220767.1\|480388_482011_-\|amidase	unknown	unknown	gnl\|CDD\|236161
NZ_CP018756.1\|WP_025879318.1\|470859_471216_+\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|235358
NZ_CP018756.1\|WP_004145446.1\|471632_472262_+\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NZ_CP018756.1\|WP_079220769.1\|484626_485118_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_CP018756.1\|WP_192851832.1\|479130_480318_+\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|223740
NZ_CP018756.1\|WP_079220761.1\|469146_470514_+\|preprotein-translocase-subunit-SecY	unknown	unknown	gnl\|CDD\|236412
NZ_CP018756.1\|WP_079220771.1\|486391_487006_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP018756.1\|WP_079220765.1\|474689_476822_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP018756.1\|WP_079220766.1\|477043_478435_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP018756.1\|WP_079220762.1\|472318_473317_+\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP018756.1\|WP_079220764.1\|474087_474594_+\|disulfide-bond-formation-protein-B	unknown	unknown	gnl\|CDD\|235294
NZ_CP018756.1\|WP_079220772.1\|487700_489581_+\|propionate--CoA-ligase	unknown	unknown	gnl\|CDD\|182517
NZ_CP018756.1\|WP_079225098.1\|490361_491417_+\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP018756.1\|WP_004145443.1\|471227_471617_+\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP018756.1\|WP_004154498.1\|468696_469140_+\|50S-ribosomal-protein-L15	unknown	unknown	gnl\|CDD\|235523
NZ_CP018756.1\|WP_079220768.1\|482052_482520_-\|DUF2127-domain-containing-protein	unknown	unknown	gnl\|CDD\|225842

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079220770.1\|485235_486222_+\|malate-dehydrogenase	gnl\|CDD\|235468	PRK05442, PRK05442, malate dehydrogenase; Provisional.	0
NZ_CP018756.1\|WP_079220763.1\|473506_473890_+\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	2.27344e-68
NZ_CP018756.1\|WP_049456418.1\|482529_484377_-\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NZ_CP018756.1\|WP_079220767.1\|480388_482011_-\|amidase	gnl\|CDD\|236161	PRK08137, PRK08137, amidase; Provisional.	0
NZ_CP018756.1\|WP_025879318.1\|470859_471216_+\|30S-ribosomal-protein-S13	gnl\|CDD\|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	2.19207e-67
NZ_CP018756.1\|WP_004145446.1\|471632_472262_+\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	1.6334e-123
NZ_CP018756.1\|WP_079220769.1\|484626_485118_+\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	5.8729e-69
NZ_CP018756.1\|WP_192851832.1\|479130_480318_+\|mechanosensitive-ion-channel	gnl\|CDD\|223740	COG0668, MscS, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	3.42366e-18
NZ_CP018756.1\|WP_079220761.1\|469146_470514_+\|preprotein-translocase-subunit-SecY	gnl\|CDD\|236412	PRK09204, secY, preprotein translocase subunit SecY; Reviewed.	0
NZ_CP018756.1\|WP_079220771.1\|486391_487006_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	6.02018e-65
NZ_CP018756.1\|WP_079220765.1\|474689_476822_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.2826e-38
NZ_CP018756.1\|WP_079220766.1\|477043_478435_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP018756.1\|WP_079220762.1\|472318_473317_+\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	4.66998e-180
NZ_CP018756.1\|WP_079220764.1\|474087_474594_+\|disulfide-bond-formation-protein-B	gnl\|CDD\|235294	PRK04388, PRK04388, disulfide bond formation protein B; Provisional.	3.17581e-102
NZ_CP018756.1\|WP_079220772.1\|487700_489581_+\|propionate--CoA-ligase	gnl\|CDD\|182517	PRK10524, prpE, propionyl-CoA synthetase; Provisional.	0
NZ_CP018756.1\|WP_079225098.1\|490361_491417_+\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	5.8812e-52
NZ_CP018756.1\|WP_004145443.1\|471227_471617_+\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	1.02985e-82
NZ_CP018756.1\|WP_004154498.1\|468696_469140_+\|50S-ribosomal-protein-L15	gnl\|CDD\|235523	PRK05592, rplO, 50S ribosomal protein L15; Reviewed.	4.42509e-65
NZ_CP018756.1\|WP_079220768.1\|482052_482520_-\|DUF2127-domain-containing-protein	gnl\|CDD\|225842	COG3305, COG3305, Predicted membrane protein [Function unknown].	8.38326e-34

>NZ_CP018756.1|WP_079220766.1|477043_478435_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
MSLSAVPPVSDPAATAAGAGWSPESWRGKTALQMPTYPDPIALDAALHELKRLPPLVTSWEILALKQQLADAQEGKRFLLQGGDCAENFSDCESGTISNRLKVLLQMSLVLVHGLRQPVIRVGRFAGQYAKPRSADTETRDGVTLPSYRGDVINAPAFTEAARLPDPKRMLQAHAHSAMTMNFVRALIDGGFADLHHPEYWNLEWVRHSPLAAEYQKMVASIGDAVHFMETLAGARVHNLNRIDFYTSHEALLLPYEQALTRQVPRQQGWLNLSTHYPWIGMRTAALDGAHVEYLRGVRNPIAIKVGPSVQPDQLLRLIDVLNPDDEPGRLSFIHRMGAAQIAEKLPPLLDAVKRDGRRVLWVCDAMHGNTESTANGFKTRRFDNVRGEVEMSFDLHAAAGTRLGGVHLELTGEDVTECTGGARELTERDLERAYRSTVDPRLNYEQSLEIAMAIVRKQEQAR
>NZ_CP018756.1|WP_079220765.1|474689_476822_-|TonB-dependent-receptor
MKPSLLATGITFALALASLPNLALAADAGTDAAPVKDLDTVTVSAQLDQARNALSPDIGSSQYQITAEDIQKQPLGASAPLSQVLLQAPGVVQDSYGGVHVRGDHANLQYRINGVLLPESISGFGQTLDARTIKSIRLMDGALPAQFGERTAAVVDITTRSGAELGNGGSVGITTGSFGKVNPNASWWGSQGRWSWFLTGNYDQNEVGLENPTSSRKPEHDDTHQGKAFADLTYLVNDTTRLSVFAGFANNRFQIPVNPGQTPQFGYLDTTTFDSSQLDETQRETTRFGMLVLQGTLGETAYQVSAGQRYSDVGFNPDVAGDLVFSGVASQVQRSNRANTLQADFSTPLGDNHTLRYGVYGNQERARASNNSWVFPVDDDGAQASTTPLQIADNSAFKATTLAVYVQDEWKIGDDWTVNYGLRGDRYKAFGQTEGQLSPRLGVVWTASDSTTVHAGYSRYFTPPASELIATSDISLYDGTTNAQPSGGNNIPLAERSDYYDIGVSQQVGDHLTLGLDAYDRRVSRLQDEGQFGAAYIYSTFNYRRGHIRGLEFSADYSNGPFSAYFNAALNKAIGTDVITSQYNLDPEALAYVADHWIHLDHDQKLTSSGGFSYAFAGHNRVGANYVFGSGLRSDTDTVPNGGELPSYLQVNLSAGHDFNADSGHPLHMQVALINALDRSYQLRDGGGVGVFAPQWGPRRGAYLSLQQDF
>NZ_CP018756.1|WP_079220764.1|474087_474594_+|disulfide-bond-formation-protein-B
MNPLRWPFRAQFLLGFLICAGLLGFAIFLQLKMGLEPCPLCIFQRLAFAALGLLFLIGALHGPSNRPGRATYGILAFIAAAVGFGIAARHVYVQMLPPEMGSTCGPPLAFLSETMGPLEVFRTVLTGTGNCGNIDWTFLGMTMPMWSGVWFVLLALWALVVSLRKVKR
>NZ_CP018756.1|WP_079220763.1|473506_473890_+|50S-ribosomal-protein-L17
MRHMKSGRKFNRTSAHREAMFKNMAASLFKHELIKTTLPKAKELRRVAEPLITLAKVDSVANRRLAFARLRDNEAVGNLFTILGPRYANRPGGYLRLLKCGFRAGDNAPMAYVELVDRPAVAEEVAE
>NZ_CP018756.1|WP_079220762.1|472318_473317_+|DNA-directed-RNA-polymerase-subunit-alpha
MTVTANQVLRPRGPQIERLTDTRAKVVIEPLERGYGHTLGNALRRVLLSSIPGFAITEVEIDGVLHEYTTVEGLQEDVLEVLLNLKDVAIRMHSGDSATLSLSKQGPGVVTAADIKVDHNVEILNSDHVICHLTKDTAINMRLKIERGFGYQPAAARRRPDEETRAIGRLVLDASFSPVRRVAYAVEAARVEQRTDLDKLVIDIETNGTIDAEEAVRTAADILSDQLSVFGDFTHRDRGAAKPANNGVDPVLLRPIDDLELTVRSANCLKAESIYYIGDLIQKTEVELLKTPNLGKKSLTEIKEVLAQRGLSLGMKLENWPPAGVASHGMLG
>NZ_CP018756.1|WP_004145446.1|471632_472262_+|30S-ribosomal-protein-S4
MARYIGPTCKLARREGADLSLKSPARALDSKCKLEQKPGQHGATARKGKLSDYATQLREKQKVKRIYGLLERQFRNYYKKASTKKGNTGENLLQLLETRLDNVVYRMGFAVTRPAARQLVSHRGVTVNGKSVNLASYQVKAGDAIALSEKAAKQLRVQEALTVAAQHDLSPSWVEVDSGKFTGIFKAVPDRSDLPADINEALIVELYSK
>NZ_CP018756.1|WP_004145443.1|471227_471617_+|30S-ribosomal-protein-S11
MAKPAAKTKKKIKRVVTDGVAHVHASFNNTIVTITDRQGNALSWATSGGAGFRGSRKSTPFAAQVAAEKAGRAALDYGVKSLEVRIKGPGPGRESAVRSLNNVGYKITNIIDVTPIPHNGCRPPKKRRV
>NZ_CP018756.1|WP_025879318.1|470859_471216_+|30S-ribosomal-protein-S13
MARIAGVNLPAQKHVWVGLQSIYGIGRTRSKKVCEVAGVTSTTKIRDLSEPEIERLRAEVGKYIVEGDLRREIGIAIKRLMDLGCYRGLRHRRGLPLRGQRTRTNARTRKGPRKAIRK
>NZ_CP018756.1|WP_079220761.1|469146_470514_+|preprotein-translocase-subunit-SecY
MAQAGIGNLAGGMGKFTELRQRLLFVVGALIVYRIGCYVPVPGVNPDAMLAMMQQQGGGIVDMFNMFSGGALHRLSIFALNVMPYISASIVMQLATHIFPALKAMQKEGESGRRKITQYSRIGAVLLAVVQGGSIALALQNQVAPSGAPVVYAPGMGFVLTAVVALTAGTMFLMWVGEQVTERGIGNGVSLIIFAGIVAGLPGAVIHTFDAYRDGNIQFIQLLLIAIVVLAFTFFVVFVERGQRRITVNYARRQGGRNAYMNQTSFLPLKLNMAGVIPAIFASSLLAFPATLAMWSGQAANQSAVGQTLQKVANALGPGEPLHMIVFAALITGFAFFYTALVFNSQETADNLKKSGALIPGIRPGKATADYIDGVLTRLTAAGSAYLVIVCLLPELMRTQLNASFYFGGTSLLIVVVVVMDFIAQVQAHLMSHQYESLLKKANLKGGNRGGFARG
>NZ_CP018756.1|WP_004154498.1|468696_469140_+|50S-ribosomal-protein-L15
MTLRLNELSPAPGARTERTRVGRGIGSGLGKTAGRGHKGSFARKGGGKIKAGFEGGQTPMQRRLPKIGFRSPIAKDTAEVLLYALDKLPAGEIDFAALRAAKLVPSTAKKAKVVVKGEVTKAFTLKGIAATAGAKAAIEAAGGSVTE
>NZ_CP018756.1|WP_192851832.1|479130_480318_+|mechanosensitive-ion-channel
MRDPVHSRVRVEVASVHWQHMQAYAWPLGLALVIGGIGAWMILWIYHRLKGRDRRRARIGRVLGLPLATALPLLLLIPALQATPLQDPLLGNLQRVLHISLVACFIWLLVRGVSAIERAILRSNPIDVADNLEARRIQTQTRVLSRVIMGGIIVLGASLVLLQFDMVAKIGSALLASAGLIGLVAGIAAKPVFGNLIAGLQIAVTQPIRLDDVVIVEGEWGRIEEIGSSYVVVRIWDERRMVVPLTWFIENPFQNWTRRSADLLGTAFFWLDYRAPIAAIRAELERICRGEALWDGRVCVTQVTDTSERAIQVRLLVSARSSGDAFDLRCLVRERMLDFLAREHPQSLPQVRARLQHEDELDMPRGPRARTADVRSPGAEDGEAAIVPGEPEPER
>NZ_CP018756.1|WP_079220767.1|480388_482011_-|amidase
MRPFLPSLLTCLIAALPALLAVGCSPATPAAHAAAPGSSNVPFPYAETDVADLQARMVSGELDSATLTAAYLKRIAALDRTGPRLRAVLELNPDALKEAAERDRERRAGRLRGPLHGIPVLLKDNINAAPMATTAGSLALQGFKPGDAYLVRRLREAGAVVLGKTNLSEWANFRGNDSISGWSARGGQTRNPYRLSHSPCGSSSGSAVAVAANLASVAIGTETDGSIVCPAAINGVVGLKPTVGLVSREGIIPISFSQDTAGPMTRSVADAAAVLTAIAGRDDADPATATMPGRAVYDYTARLDPQGLRGKRLGLLQTPLLKYRGMSPLMDHAVAELRRAGAVVVPVAMPNQGAWDEAERTVLLYEFKAGLERYFTTYQAPMRSLAELIAFNQAHAKQELGLFGQQLLQEADATAGLADPAYIRARSDAKRLAGPEGIDAVLAAHQLDGLIAPTTGIAWPLRSSGDDFPGESYSAAAVAGYPSLSVPMGQIDGLPAGLLFMGTAWSEPKLIEMAYAYEQRTRARQPPRFATDALIDAGDP
>NZ_CP018756.1|WP_079220768.1|482052_482520_-|DUF2127-domain-containing-protein
MSQNGYNPDPHRHPGLHVIALLEASKAMLALLAATGLEMLGPQPLRDGVNALIRRFSLDPDHGTLPSLLNMISPDAVHLAAAAMIGYGLLHLVEAWGLWKAKAWASWLGCLTASIYLPFDIYAVLRHPGWASWSVLAINLIVVYVLARDLRKRRH
>NZ_CP018756.1|WP_049456418.1|482529_484377_-|translational-GTPase-TypA
MSIENLRNIAIVAHVDHGKTTLVDQLLKQSGTLSERTVLAERVMDSNDQEKERGITILAKNTAITWEDKKTGIKNRINIVDTPGHADFGGEVERVLSMVDTVLILVDAMDGPMPQTRFVTQKAFAMGFKPIVVVNKVDRPGSRPEWVIDQVFDLFDKLGATNEQLDFPIVYASALNGYAGLEDTVRDGDMTPLYEAIMQHAPKPEVDPEGAFQMRISQLDYNNFVGVIGIGRIQRGTLKKNMQVAVIDREGKKRNGKVAQVLGFLGLERIEQDTAEAGDIVAISGIPELTISDTLCHPDTPEALPALTVDEPTISMTFQVNNSPFAGNKDLSGGKFLTSRQIKDRLDREKVHNVALKVEQLEDADKFLVSGRGELHLSVLIENMRREGYELAVSRPEVIIKEIDGQMMEPIEQLVVDIEEIHQGGVMEKLGTRKGQLKNMEPDGKGRVRLEYSIPARGLIGFQNEFKTLTQGSGLLFHVFDHYGPKEQGAIAKRINGVMIANAPGTTPAYSLGPLQERGKLFAAEGDNVYEGQLVGIHSKDNDLTVNAIKTKPLTNMRASGKDDAIQLTPAIKYSLEQALDFIEDDELVEITPKEIRLRKKFLTESDRKKASRGG
>NZ_CP018756.1|WP_079220769.1|484626_485118_+|peptidylprolyl-isomerase
MSLIATFDTTQGPIKVELFADKAPLTVANFVNLVKQGFYDGLIFHRVIADFMIQGGCPQGRGTGGPGYKFEDEKNGVKHEVGSLSMANAGPNTNGSQFFITHIKTDWLDGRHTVFGKVLEGQAIVDSVKQGDVIHSITLEGDVDAALAAQADRVAEWNKILAA
>NZ_CP018756.1|WP_079220770.1|485235_486222_+|malate-dehydrogenase
MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPVDKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAFKDADIALLVGARPRGPGMERKDLLLENAKIFTAQGAALNKVASRDVKVLVVGNPANTNAYIAMKSAPDLKPENFTAMLRLDHNRALSQLSTKLGKPVGGMEKLVVWGNHSPTMYPDYRFATADGASIADAINDQEWNANTFIPTVGKRGAAIIEARGSSSAASAANAAIDHVRDWVLGSNGKWVTMGVPSDGSYGIPEGVIFGFAVTTENGKYTLVKDLPIDDFSQKYIDKTLAELEEERSGVAHLLG
>NZ_CP018756.1|WP_079220771.1|486391_487006_+|RluA-family-pseudouridine-synthase
MIHLHYIDDALLVAEKPAGLLSVPGRSVENQDCVVARLQALYPDALTVHRLDQVTSGLLLHARGKAMQAALSMQFEQRQVSKRYEAVVQGLLEAEAGAVDLPLIVDWPNRPKQQVDHERGKPALTRWRVLARDVQAQRTRVALEPVTGRSHQLRLHMASLGYPIVGDVLYGATPAQRVYLHACALAFSHPVTGAALAFESAAPF
>NZ_CP018756.1|WP_079220772.1|487700_489581_+|propionate--CoA-ligase
MNYEETYRRSIDEPEAFWGEEAKRIYWHVPPKQVLDYSNPPFRRWYVGGETNLCYNAVDRHLVDRPDQLALVAVSTETNITREITYRQLYREVNDFAAVLQRLGVGHGDRVVIYMPNMAEAVFAMLACARIGAVHSVVFGGFAAHNLALRIDDAKPKLLIAADAGMRGGKVIPYKAMVDAACAEATSPPPHVLIVSRGLDPAEPRVPGRDVDYAALRAQVGEVDVPVKWLESSEPSYLLYTSGTTGKPKGVQRDVGGYAVAMAQSMQTVFDCQPGQVMFSTSDVGWAVGHSYNVYGPLIGGCTSLLYEGLPTNPDPGIWWALCEQYNVRTMFSSPTAIRVLKKHDADFIHRHDLDALKYLFLAGEPLDEPTAHWISEALGKPIIDNYWQTETGWPALTLLPGLDMKPVRFGSPGFPNLGYRMKVIDENTGEEVAAGQKGVLVVTPPLPPGCMSTVWNDDARFMQSYFSHFKELLYSSLDWAIRDDDGYTFILGRTDDVINVAGHRLGTREIEEAISGHPRVAEAAVIGVKDELKGQVPLVFVTLKQGLNGEDPAPVVAEMMAAVTASLGAVARPAHVHVVNALPKTRSGKLLRRSLQALAEQRDPGDLSTLDDPGALEEIRRALGR
>NZ_CP018756.1|WP_079220773.1|489807_490311_+|hypothetical-protein
MALLHAKTAAGRQEIEDRGRRLPAGLRSILLMVDGRRDDNELRGLLEGLRAPPDALQQLAALELIEVVGGAVEPVAARALSSGREQDPALYQQLYEAMSEAVRRHLGLKGYFMQLKIERCKDALSLERLCPELLDAVAKARSPALAQRWWQETQVLLSPAAGEVVQA
>NZ_CP018756.1|WP_079225098.1|490361_491417_+|suppressor-of-fused-domain-protein
MQDEHDTTDTPGWDAINAALAPLYAGQEPRHYGTALPYTLGGQDPLDGISVYWADAPVPHWHYITYGFSELYAKESSDADTSGYGFELTFRLAASAGEHAGSTPPMWPLNLLQNLARYVFGSGNVFEDGHHLDANGPIALETDTRLCHLAFIADPQLPARDTANGHLQFLQLVGLTDEEMEAIRRWSTRGVLQALQPAMPLWITDLHRGNLLDDPALAAQAREGSEREGSTTGMLFIETLGWRQEAGVTTLVLGAGQVPSVSELLGLRLRHGKPLELVSRERQWTFVPADGDSVEEVEGDSARWLLDEAGLQAMAAVPAERGLYPVGSRLRIEVVPTQLRDGKGAVIREIG

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Crispr_ID: NZ_CP018756_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_3

746279-746400

Orphan

Consensus_repeat	Method
CCGCACTTGCCTTCGCCGCACTGGCCTTC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP018756_3

>merge|NZ_CP018756|3|746279-746400|CRISPRCasFinder
GCAAACGAGGCGTCGCCGCACTTGCCTTCGCCGCACTGGCCTTCGGCCACCTTGGCCTTGCCGGCGGGCTTGCTGCTGGCAGCCTTGTTGGCACCGCACTTGCCTTCGCCGCACTTGCCTTC

>NZ_CP018756|3|3|746279-746400|CRISPRCasFinder
GCAAACGAGGCGTCGCCGCACTTGCCTTC	GCCGCACTGGCCTTCGGCCACCTTGGCCTTGCCGGCGGGCTTGCTGCTGGCAGCCTTGTTGGCA
CCGCACTTGCCTTCGCCGCACTTGCCTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221007.1\|743312_743717_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221004.1\|739123_739435_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP018756.1\|WP_079221018.1\|753563_754022_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221019.1\|754053_754380_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225129.1\|742083_743241_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP018756.1\|WP_079221010.1\|745171_746017_-\|DUF692-domain-containing-protein	unknown	unknown	gnl\|CDD\|235447
NZ_CP018756.1\|WP_079221020.1\|754453_755173_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP018756.1\|WP_079221012.1\|746640_747285_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP018756.1\|WP_079221016.1\|751197_752457_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340925
NZ_CP018756.1\|WP_079221005.1\|740162_740387_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226181
NZ_CP018756.1\|WP_079221006.1\|740429_741968_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
NZ_CP018756.1\|WP_079221017.1\|752461_753409_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239116
NZ_CP018756.1\|WP_079221015.1\|749808_751122_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018756.1\|WP_079221014.1\|748465_749011_+\|redoxin-family-protein	unknown	unknown	gnl\|CDD\|239310
NZ_CP018756.1\|WP_079221008.1\|743755_744394_-\|ferric-reductase-like-transmembrane-domain-containing-protein	unknown	unknown	gnl\|CDD\|235452
NZ_CP018756.1\|WP_079221009.1\|744396_745179_-\|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225760
NZ_CP018756.1\|WP_079221013.1\|747667_748462_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378924
NZ_CP018756.1\|WP_079225131.1\|749071_749812_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP018756.1\|WP_079225128.1\|739681_740149_+\|DUF2975-domain-containing-protein	unknown	unknown	gnl\|CDD\|378586
NZ_CP018756.1\|WP_079221003.1\|737717_739109_-\|DUF2867-domain-containing-protein	unknown	unknown	gnl\|CDD\|378548

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221004.1\|739123_739435_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.51179e-18
NZ_CP018756.1\|WP_079225129.1\|742083_743241_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.29472e-75
NZ_CP018756.1\|WP_079221010.1\|745171_746017_-\|DUF692-domain-containing-protein	gnl\|CDD\|235447	PRK05409, PRK05409, hypothetical protein; Provisional.	1.06567e-144
NZ_CP018756.1\|WP_079221020.1\|754453_755173_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.64833e-45
NZ_CP018756.1\|WP_079221012.1\|746640_747285_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	5.28257e-12
NZ_CP018756.1\|WP_079221016.1\|751197_752457_+\|MFS-transporter	gnl\|CDD\|340925	cd17367, MFS_KgtP, Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters. This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.47955e-89
NZ_CP018756.1\|WP_079221005.1\|740162_740387_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	2.82165e-23
NZ_CP018756.1\|WP_079221006.1\|740429_741968_+\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	2.59866e-97
NZ_CP018756.1\|WP_079221017.1\|752461_753409_-\|nucleoside-hydrolase	gnl\|CDD\|239116	cd02650, nuc_hydro_CaPnhB, NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	1.70677e-115
NZ_CP018756.1\|WP_079221015.1\|749808_751122_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.56026e-37
NZ_CP018756.1\|WP_079221014.1\|748465_749011_+\|redoxin-family-protein	gnl\|CDD\|239310	cd03012, TlpA_like_DipZ_like, TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.	2.18024e-63
NZ_CP018756.1\|WP_079221008.1\|743755_744394_-\|ferric-reductase-like-transmembrane-domain-containing-protein	gnl\|CDD\|235452	PRK05419, PRK05419, protein-methionine-sulfoxide reductase heme-binding subunit MsrQ.	0.00109838
NZ_CP018756.1\|WP_079221009.1\|744396_745179_-\|putative-DNA-binding-domain-containing-protein	gnl\|CDD\|225760	COG3219, COG3219, Uncharacterized protein conserved in bacteria [Function unknown].	3.74348e-38
NZ_CP018756.1\|WP_079221013.1\|747667_748462_+\|alpha/beta-hydrolase	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	8.87923e-11
NZ_CP018756.1\|WP_079225131.1\|749071_749812_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.02744e-76
NZ_CP018756.1\|WP_079225128.1\|739681_740149_+\|DUF2975-domain-containing-protein	gnl\|CDD\|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	5.56199e-05
NZ_CP018756.1\|WP_079221003.1\|737717_739109_-\|DUF2867-domain-containing-protein	gnl\|CDD\|378548	pfam11066, DUF2867, Protein of unknown function (DUF2867). This bacterial family of proteins have no known function.	9.05709e-18

>NZ_CP018756.1|WP_079221010.1|745171_746017_-|DUF692-domain-containing-protein
MSLPLPSASAGLGLRRGLIDELLAMPADAIDFLEVSPDNWIGVGGAHGAALRQLSERHRLTCHGLSLSLGGPDPLDRTLLAQTRAFLDLHQVQLYSEHLSYCAAGGHVYDLLPLPFTSEAVHHVAGRIAQVQDMLGRRIAVENISYYAVPGADMSEIDFINAVLAEADCDLLLDVNNVFVNACNNHYDAFDFLARVPAHRVASLHVAGHFDEDDGFKIDTHGAPVKGVVWALLREAYARVGVRPTLLERDFNFPPLAELLAEVVQIRQAQADVRLPEVAHG
>NZ_CP018756.1|WP_079221009.1|744396_745179_-|putative-DNA-binding-domain-containing-protein
MAEPLAALQQRWADHVRDPSRPAPEGVDARRLAVYRRLCIDSLDSLLAGCLPQLQQQLGATRWRDVVEHYYARHACHTPLFPQIANEFAAWLALQDSLALPAWAAELAHYESTQQALHIEARDAGQTLHHVAVGSDLLAVSPLVRVLGYQWPVHEDAVLDDAPATTPTLLLLRRQADYRLQVETLAPLAYALLSVFGHDGVRVDDALQALADAHGVLVEELRVACAPLLAELCAAGVLVVLAGFQSCRPAAGTTHFHSEV
>NZ_CP018756.1|WP_079221008.1|743755_744394_-|ferric-reductase-like-transmembrane-domain-containing-protein
MAVSNTPLLSGWRLFVAIAGVLIACALAAFALQADVAEGSRAAIRVTARTSFLLFLAAFTASSFASLLPGPTTRFLLRERRTIGLSFAFSHLLHAIAITVFGILNPAFWPARSALANLPGTVGYVAILALAITSHRAIARRMGPTAWRRLHVTGMWIIAAVFTYSYFKRVPGNFWYAVPSALLFTALVVRAIAKRAQSLKRHLHARPVLRSS
>NZ_CP018756.1|WP_079221007.1|743312_743717_+|hypothetical-protein
MSHSRAPMERLIRANADEINRLRQAIREAAGARWRGPEEMQRHAAACAEYNQRYEQLAFPGGYVNALNQLAEHDPDTVDVVLTFLEVRPYFFRSGYMWKTLLKRVQRVPMGAKQQARMQKILDTYAAYRAAIPL
>NZ_CP018756.1|WP_079225129.1|742083_743241_+|metallophosphoesterase
MAGPTFRNVAVLSTIGLLMGLYVAWRLFWPLRLPVWAKAVVSLLLVGLAVQLRIVATFWGTMASPEIPKMAIAVLATGSTAVLLLALAMLLFDAGLLAARVLRLPRAVSALRAPLLRPSAAAVALLLSGYGVSQGMAVPQPRQVEVAIKDLPAAFDGYRMLQLTDIHASRLLTGDWVRQVVAESNALKPDLIVITGDLIDGTVDARRDDFRPLGDLQAPDGVIAITGNHEYYAQYSDWMQAFRALRMQVLENSHTQVRRGDAALTIAGVTDPVAARYGLPLPDLQAALAGADPAAPVILLDHRPRNAVDAAARGVKLQLSGHTHGGQIIGMDQLVKRANGGFVSGRYEVDGMTLYVSNGAGLWAGFPARIGVPSEITLFTLHRAP
>NZ_CP018756.1|WP_079221006.1|740429_741968_+|TerC-family-protein
MEWLADPSIWMGLATLIVLEIVLGIDNLVFIAILADKLPPHQRDRARVIGLSLALLMRLVLLAALAWIMKLTEPLLTLFDHSFSGRDLILLGGGLFLLFKGTMELHERLEGRQHHEDGKKVYASFAMVVAQIVVLDAVFSLDSVITAVGMVDNLGVMYAAVTIAMVLMLLASKPLTRFVNKHPTVVVLCLGFLLMIGFSLVAEGLGYKIPKGYLYAAIAFSILVEAFNQWVRFNRERNERRQPFRQRTADAVLRMLGARPANGHDDAGEEDHGDAEERLQPAEHEMIRSVLGLADRPVSSVMTVRADVQWIDLARGQDDVVARLVASPHTRLLVGEGDLDSLRGVVQSRDLLADLLQGQPLQLEANLRQPQYVLSSASALQALELIRLHPVPLAVAVDEYGSVEGLVTANDLLAAIAGDLADTQDDRYGVVAQGEDHWEADGALTLDDLQRLAGVSLPRSSDYMTISGLVLDQLGRLPDEGDAVDVADVRITVLAMEKRRIARLRVQRLVGT
>NZ_CP018756.1|WP_079221005.1|740162_740387_+|helix-turn-helix-transcriptional-regulator
MAIVITLDRMLQARGMTLSELAGRIDITLANLSILKTGKARAIRFSTLDAICRELQCTPGDLLGHDPLQAQDDD
>NZ_CP018756.1|WP_079225128.1|739681_740149_+|DUF2975-domain-containing-protein
MCWLGILAALLAIPLVAYDRRWLLASVHDAHAAAVHGSDLFLHFCIGLGTIVALLVLCLVFLRHLARLLRSAAGARPFTHANAQRLQRMAWLMLAMEVLSIIIGVYASWMGPDFAWMEVGGGMSITGLIAVLMLFVLARVFAVGAAMRDDLDGLI
>NZ_CP018756.1|WP_079221004.1|739123_739435_-|winged-helix-turn-helix-transcriptional-regulator
MDRIFEALASGARRQILAYLSAGELSAGELAERFDFSKPALSSHLRILEEAGLIEREKRGQFVYFRQVPERLANTLFSWAAEVCPVGGPLKREARARRKSPAR
>NZ_CP018756.1|WP_079221003.1|737717_739109_-|DUF2867-domain-containing-protein
MPGSTRNSRSFPGVQLPAQDGAGPIEVTLIAQLGIGAGDALVNDAGERQRHHPAFIDALDEPSARLGGMHLQHGDASSLYSFVVEGGGHPFHRHAGPRMFTAIAGSAGAELRFATAADAQLAGDPSAFLRSLRRIRIPPDCLFTVRFGGGTWHQFASNHPAHPALFALSCHSNELAGAMSEATRARVQANSADIPSLTEVLAQQHWPSAAMLATAPLLQLSLQAAPPSLCARLCAQTRSMLGPLRRIKLRPLRGFVERSTPRYPVHSGRPDAQGLLAGALPHSHYHDLTVLTLRSGHCTQRSASALLADVLEGFLRNPPGGVGRLMALRNRLVAPLRLRTSPLGCPVSSLLSADRSRLFAGRFPVLDARVDGADRSAEVLLGADDRHLRFRSSVRVQFEDDGRVQISLGSRVQTHNRFGRLYMALIDAVHRHYIAPALLRRAVEHALAPELADWVDEGVAAAG
>NZ_CP018756.1|WP_079221012.1|746640_747285_-|DoxX-family-protein
MISTASSLYTPRLDAVGRWLSPLALRTLLAWEFFESGREKLGGQNWFADLEGRFPFPFSTLPASLNWQLATWLELVGAVMLLLGLATRSVAYIFWVLTVVAIAAVHWPDQWNGLGELWQGYAITDQGYGNFKLPLLFLAMLLPLILNGGGALSLDRLLAGPQRAIAGDDGLGWGVSLVALLLPIAALLPGIGFGGALLGAALLLAYVLRRRRSA
>NZ_CP018756.1|WP_079221013.1|747667_748462_+|alpha/beta-hydrolase
MIRTTLLAAALALAGAATPAFAAQADAVAPPTVVLVHGAFADGSSWNKVITTLRDWKLPAVAVQNPLTSLADDVAATRRAIAAAPGKVVLVGHSWGGTVITEAGNDPKVQALVYVAAFAPDAGQSSAQQGEGFPVGPGLTRLQEKDGYLTLPADAIAQDFAPDVMKKTAALLYSTQVPLKASALGEAVTTAAWRSKPSWYVVSRDDRMLSPQLQVATAHRIGAQLQSIGSSHVSLLSHPAQVADSILEAAGVKPAELPLAEQGG
>NZ_CP018756.1|WP_079221014.1|748465_749011_+|redoxin-family-protein
MATLRAYTVPLLLALLGGAALLLAWPSPEAGAQTAEAAPAAGFNGGGPWHNSPPLALEQLRGQVVLVEFWTYGCSNCLNVAPYVHRWHARYAPKGLRVIGVHTPEFAYEGLQGNVRHAIHRLDITWPVVQDNQYRIWNAWGNRFWPALYLVDRQGRVVYRHYGEGDYARTESEIQRLLASP
>NZ_CP018756.1|WP_079225131.1|749071_749812_+|response-regulator-transcription-factor
MNHVPHILVVDDDSDIRQMLADYLQRNGLRVSQADGGRAMRALMDTHAVDLVVLDVMMPGEDGLSLCRNLRAGKHRAVPVVLLTARDDETDRIIGLEMGADDYVTKPFSSRELLARINAVIRRTQMLPPNLQVSEAGRQLAFGDWRLDTTARHLLDAQDTAYPLSGAEFRLLRVFLDHANRVLSRDQLLSLTQGRDAELFDRSIDLLVSRVRQRLGDDAREPTYIKTVRSEGYVFSVPVQLLGPEE
>NZ_CP018756.1|WP_079221015.1|749808_751122_+|HAMP-domain-containing-histidine-kinase
MNAAARRLPWPRTLSARLLLLLLGGLTLAHALSFGLLFFERYQATRSMMLRNLDEDVAVSVALLEHLPADQRQAWVPRLERRTYRYLLRPAASGPALETGRARQVTAIIDDSLEHRYPLQARQVARLPERFEVELRLRDGTPLTIEVTPSGLPLARWLPAVLLVQLALLLLCAWLAVRLALRPLQQLSHAVEHLQPGKDAAVLPEDGPAEVGAAAAALNALQARIRGHVSERLQILAAISHDLQTPITRMKLRVETLPEDATQQRLLDDLDHLGLLVREGVAYARSSHVASGAPVAMDLAAFLASVVGDYEDMGKPVSGGAPAGLTVQTWPQPLRRVVGNLVDNALRYAGSAEIDAGRDAAGKPWISVSDRGPGIPEDQLQAVLAPFHRLESSRNRDTGGTGLGLAIAVQLAQSLGGSLQLRNRDGGGLQAVLQLPG
>NZ_CP018756.1|WP_079221016.1|751197_752457_+|MFS-transporter
MTAARQRSMWVAGLSTVVEWYDFTLYLYFATVLSRVFFGGGEQAMLVTLAGFAVSYLMRPLGALCFGHLGDRLGRRWMLLASMALMAAAMLATALLPTAATAGTTAGILLLVLRCVMAFSVGGEYTGVVAYLLESAPARRRGLVTSLASAASEVGALLAVAISAVTVATLTPAQLDGWGWRIPFFVGAALALVILIARSGMHESPEFERQRREGSIPATPLRHVLRNHPGAVARTFAISALGSITYYVGITYVPAFLHAQGHDEGDALWLSTVAAVAVIAITPLCGMLSDRFGRRPLLLGLTVLAALLPLSMFGWMAEAAPLGIALAAVVLACVAGGVSAVAAPATAEQFPGEGRVSGLALGVTMATAVFGGATPWLAQWWVERSGWAAAPGAMIALVAVLVLPVLWTLPETTPGRAKR
>NZ_CP018756.1|WP_079221017.1|752461_753409_-|nucleoside-hydrolase
MLKVIFDTDPGVDDALALLYLHKHAQIDLVGVTTTFGNASVESTTHNALYLKQAWGFAAPVARGAAGPLQPEATPEAWPVHIHGHNGLGNHPVPTALDVAADARPAHQLIIDLVRAHPGEVTLVAVGRMTNLALALQHAPDIAGLVRGVVLMGGAFHVNGNITPAAEANIWGDAEAADIVFTAQWPVTAIGLDVTTRVEMDRDGLDKLAAIGGADAELVRALSQDYVDFYLQAGHKGMVVHDCCACIALTHPELFQFERASVRVATDGVARGMTIPKPEGLAFGPSVWDGHVLQSIAIGVDAPAVLADIEQTLAV
>NZ_CP018756.1|WP_079221018.1|753563_754022_+|hypothetical-protein
MKTPAILLAGLLCLGAVAPALATSVAPKPLAEMVAEADQIVRAKVVDVEMVDGKGRPLTDPGSRTGPGLDNEIRLVLQVQEVLRPREGRVPATIRVPLWTMWHYTLGHIREATLGSESLFLLKGERHAPVYPVGFQRPLDERAQIQSLMVAP
>NZ_CP018756.1|WP_079221019.1|754053_754380_+|hypothetical-protein
MLVVTLVLIALVLGLNLVATYVVVRRDGVSVGGRAVQLLLVWLLPLVGAILCMAIATADGSVSRSEGSFAGSYDSSGSYASDSHNSHSYSGSDCSSDSGGGDGGSCSD
>NZ_CP018756.1|WP_079221020.1|754453_755173_-|GntR-family-transcriptional-regulator
MAIAPAPRSPKKRAPLYEEVAEHVRERIYDYRLPPGEWIDEPALCEELGISRTPLREALKLLAAEGLVQIDAGRGARVTRLTLEDLNQLFPVMAMLEGRCAHEAVRHIDDAGVQQLEDLHAAMEAAAANGNIAEYYRNNYLIHETVQHYAGNPWLIRITHDLHRILKMHRGRQLLAPGRTAQSLAEHRELMDCFRRRDAQAAERTMERHLLSQGQALAAYVADGGLLNVPAPLPTEGGG

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Crispr_ID: NZ_CP018756_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_4

1355480-1355575

Orphan

Consensus_repeat	Method
GGTGCCGAGCGTTGCTCGGCACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_4

>merge|NZ_CP018756|4|1355480-1355575|CRISPRCasFinder
GGTGCCGAGCGTTGCTCGGCACGCCATGGAACTCTCAGTCGCATCGATGCTCGAGGGCTCCTGCTCCCGGTAGGTGCCGAGCGTTGCTCGGCACGC

>NZ_CP018756|4|4|1355480-1355575|CRISPRCasFinder
GGTGCCGAGCGTTGCTCGGCACGC	CATGGAACTCTCAGTCGCATCGATGCTCGAGGGCTCCTGCTCCCGGTA
GGTGCCGAGCGTTGCTCGGCACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221520.1\|1344715_1345195_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176905
NZ_CP018756.1\|WP_079221521.1\|1345249_1345882_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP018756.1\|WP_079225182.1\|1353152_1354568_+\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|223492
NZ_CP018756.1\|WP_079221525.1\|1351088_1351715_+\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP018756.1\|WP_079221527.1\|1352458_1353043_-\|SMI1/KNR4-family-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221523.1\|1348594_1349716_+\|phytase	unknown	unknown	gnl\|CDD\|271320
NZ_CP018756.1\|WP_079221537.1\|1365185_1366607_+\|efflux-transporter-outer-membrane-subunit	unknown	unknown	gnl\|CDD\|273830
NZ_CP018756.1\|WP_079221529.1\|1355839_1356565_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NZ_CP018756.1\|WP_079221533.1\|1359007_1359778_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236372
NZ_CP018756.1\|WP_079221530.1\|1356682_1357567_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176163
NZ_CP018756.1\|WP_079221535.1\|1361220_1364391_+\|multidrug-efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079221536.1\|1364454_1365192_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187585
NZ_CP018756.1\|WP_079221524.1\|1349712_1351077_+\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|379868
NZ_CP018756.1\|WP_079221531.1\|1357608_1358637_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP018756.1\|WP_079221538.1\|1366674_1367532_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197317
NZ_CP018756.1\|WP_079221534.1\|1359869_1361093_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP018756.1\|WP_079221532.1\|1358783_1359011_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221528.1\|1354706_1355402_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|182507
NZ_CP018756.1\|WP_079221522.1\|1346036_1348595_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_CP018756.1\|WP_079221526.1\|1351791_1352439_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221520.1\|1344715_1345195_+\|SRPBCC-family-protein	gnl\|CDD\|176905	cd08896, SRPBCC_CalC_Aha1-like_3, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	3.1973e-81
NZ_CP018756.1\|WP_079225182.1\|1353152_1354568_+\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|223492	COG0415, PhrB, Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair].	8.67202e-160
NZ_CP018756.1\|WP_079221531.1\|1357608_1358637_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.72097e-68
NZ_CP018756.1\|WP_079221525.1\|1351088_1351715_+\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	1.06365e-73
NZ_CP018756.1\|WP_079221535.1\|1361220_1364391_+\|multidrug-efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079221523.1\|1348594_1349716_+\|phytase	gnl\|CDD\|271320	cd05819, NHL, NHL repeat unit of beta-propeller proteins. The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.	1.25062e-13
NZ_CP018756.1\|WP_079221537.1\|1365185_1366607_+\|efflux-transporter-outer-membrane-subunit	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	3.32672e-81
NZ_CP018756.1\|WP_079221529.1\|1355839_1356565_-\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	4.06394e-100
NZ_CP018756.1\|WP_079221521.1\|1345249_1345882_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	4.92945e-123
NZ_CP018756.1\|WP_079221530.1\|1356682_1357567_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176163	cd08474, PBP2_CrgA_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 5. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.17396e-91
NZ_CP018756.1\|WP_079221536.1\|1364454_1365192_+\|SDR-family-oxidoreductase	gnl\|CDD\|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.78965e-96
NZ_CP018756.1\|WP_079221524.1\|1349712_1351077_+\|metallophosphoesterase-family-protein	gnl\|CDD\|379868	pfam16656, Pur_ac_phosph_N, Purple acid Phosphatase, N-terminal domain. This domain is found at the N-terminus of Purple acid phosphatase proteins.	6.18537e-16
NZ_CP018756.1\|WP_079221538.1\|1366674_1367532_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	1.35189e-98
NZ_CP018756.1\|WP_079221534.1\|1359869_1361093_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	1.23378e-78
NZ_CP018756.1\|WP_079221528.1\|1354706_1355402_+\|OmpA-family-protein	gnl\|CDD\|182507	PRK10510, PRK10510, OmpA family lipoprotein.	2.61179e-57
NZ_CP018756.1\|WP_079221533.1\|1359007_1359778_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|236372	PRK09072, PRK09072, SDR family oxidoreductase.	6.84398e-12
NZ_CP018756.1\|WP_079221522.1\|1346036_1348595_+\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	0

>NZ_CP018756.1|WP_079221528.1|1354706_1355402_+|OmpA-family-protein
MIRNTTRNVALALMTAAALTACATGGSYVQSDQYGNPTEQQNRTGRGALIGTAVGVAAGLLSGNSATERRQHALVGAGIGALSGAAIGNYQDRQERALRERTANTGIDVQRQGDNITLNLPDGITFDFGKSALKPQFYGSLNGVASTLNEYNQTMIEVVGHTDSIGSDAVNNRLSKERADSVAQYLVGQGVQQVRIETLGAGKAYPIADNSTDAGRAQNRRVEIRVIPLKQ
>NZ_CP018756.1|WP_079225182.1|1353152_1354568_+|deoxyribodipyrimidine-photo-lyase
MSVALVWFRRDLRLQDNPALQAALDAGHEVVPVYIHAPQEEGEWVPGAASDAWRHRSLAALDADLRARGSALVLRSGDSLDALQALIEETGAEAVYWNRKYEPATQPRDASIKRTLREQGVDAQSCNGSLLFEPWDVATQQGQPYKVFTPYWRNVLSHWRLPALQPAPKKLASHGVASLALEELQLAPTLDWDTGFWEHWQPGEAGALEALSVFEDGALRGYREQRDLPDRVGTSRMSPHLHFGEIAPWRIAHALEGLRSAGTDADIDGYLRQLGWRDFAYHLLHHFPKTPNENLNPRFDRFPWANPSSAQLHDWQRGNTGVPIVDAGLRELWHTGYMHNRVRMIVASYLCKHLRAHWLHGARWFWDTLVDADLANNTMGWQWVAGTGADAAPYFRVFNPVTQAEKFDPQARYITRWVPELAALPVKARFAPWQHPLLLADKAPGYPRTPLVDLAAGRDAALAAYRSTGGE
>NZ_CP018756.1|WP_079221527.1|1352458_1353043_-|SMI1/KNR4-family-protein
MDDLHAAFARFGPLQAQDGRDWQRPFPLPPVLARFYAQIGPLGQEINAKVGRAGITIPGLEVWVPPLQRLWRHQAGYRWNGISGEPIDSWPSNWLVIADRGADPFILDLDDGRVLFSHHGAGLLEAGEIATDVPTLMAALAAAGTVYLDAGYDLYNDDDDGGIRAEHQEAAVQAVARVLGDRIDAESFIETLLG
>NZ_CP018756.1|WP_079221526.1|1351791_1352439_+|hypothetical-protein
MDANWVIGLVLVWMLLPGFFFGGRYKADLSSPRLWRRWLNRAVLYPWFHLIAAVLLMHLGNGLSSLRPELGEGLEDLGHGPAGFVLLPFPLAVVLMTIPVRVQRVLRGRRWKPGPDPEPAVLPQAVAAIRPRSRDYGQIDLADPAMIEELARSHWQVMDAADRRGLGLDHAERLQRGFLRYLLLLDDRQLAEQAASVYRRAMIAHAWDGQRERGL
>NZ_CP018756.1|WP_079221525.1|1351088_1351715_+|inorganic-diphosphatase
MNASRRIEPLAALGAALLLVAGAVTAADSVLHPFLAAQPKQAPAEVNLAVEIPAGSFTKYEIKEDGLVHVDRFQSMPVAYPANYGSMPRTLAGDNDPLDALVLTREPLHPGVIVRFRPIGYLKMIDGGEHDEKVIGVPTDKVDPTYANIRDLSDLPEIERQRIEAFFRVYKDLPAGRNPVQLNGWGNAAEARALISEAMKRFKAVPTR
>NZ_CP018756.1|WP_079221524.1|1349712_1351077_+|metallophosphoesterase-family-protein
MSRRCMNALALGLLLAVPALGFAAAEPNTQVPVGSHHYAATTVPDRIVASPSVDPSQGFAVAWRTDGSVQAPLLEIALAGDSPAIEGIRQVRAKTQELKTENGVSHHHRAEVEGLTPDTLYVYRVQGNGSWSAWNQLRTLGKAGEPLTLLYFGDTQNKNLSHVSRVVRAAQKTAPEARMSLFAGDLVSGGDGADDSEWGEWFAATSWLAQETLVAPAIGNHEYFEEFEDTPQERRVLGKHWPVTFALPGNGAAAAASSTYWFDVQDVRVAVLDGTSALDLGTAKAQAQWLDKVLANNPHPWTIVLLHQPFYSPREGRENAALRDVLLPVVRRHNVDLVLQGHDHTYGRRGEGQAATPQYVVTVAGPKQYRLSDEARRTMDPVAEDTQLFQVLKIDPQHLRYEARTVTGRLYDAFELRRDAAGGKQRVELREDRIAPRDCPRAQTAKGRADRCWE
>NZ_CP018756.1|WP_079221523.1|1348594_1349716_+|phytase
MARGMTLLAAAMAACLAAGCTPAEAPAGADTDAAAKAPAEAARSVSTIAEAFLSPMTPDDNIDSPAAWKAPDGKTWLIATAKATDKLVVYDGSTGQHLRDVGTAGTALGQFDRPNGISVTDDLLWIVERDNHRVQVFSLPDFTPLAVFGADDLRKPYGLWVDRRADGYSVYVTDSWDNGEDAQGKDILPPLAELDKRVRQYHVTRDGAKVQATLAASIGDTSEAGALRVVESIWGDPANDRLLIAEEDESYASEFKVYTLAGRFTGTTFGRDVFKAQAEGVMLRTCGKDGWWITTEQGKQRSVFHLFDRHTLKPVGAFQGNTVANTDGIWMMQQPSPRFPHGALYAVHDDQGVVAFDWEAIAKQLSLPLECGA
>NZ_CP018756.1|WP_079221522.1|1346036_1348595_+|TonB-dependent-receptor
MHIKTPLAMAITVTLALGAAAPLQAAGQQALAATGAVAADAVDLDRIEVRAQLESQIRAVDLKRSSDAIEDAVSSDALGQYPDKNVAESLQRLPGISVTRDQGEGRFVVIRGLDANLNSVSIDGIAVGTPEDSSRAAPLDVIPSDSTERLRVVKSPTPDMPGDAIGGAVLVESASAFDRDGRSLRGKIEASHQQLSGETSPKASFNYSEVFADTFGVALGVNYQNRKFESDNTEVEYDGEKDAAPGDVTAINLQNRKYEIERKRIGANLNMDWRPDEDSKYYLRTLYSQFDDAETRQRVIYNFDDADMVATGTDQFRLDDLPSDAIQKRMRYRTKKENTFAASLGGENKLTNAVVDYKIGYTRTEERVNDEMEARFELDADDMSGTLDQRSRLPTYTLSSNDWMDNANYAFDRFVISPKQVNDEERSAQVNVRFDGDSSSIKLGLLGRWRDRDVNVDESELRRGPDIDLTTWTAADPEHRHGVMGQGMSSAAMRRYWAQNGSRYTARPQDVAGNAATSLEEDYTASEDIFASYAMGTWDIGALRIIGGVRVENTRFKATGNSVELDDDDGYTVNPVQANRSYTNVLPGLHLRYDAADDWVLRASANKTVSRPSFGDISPRRALNAGDEELRLGNPQLDPYESKNIDLSVEKYIGTTGIVSLGLFHKSIDGYIVETVSQNDPAYDGLDVTRPINGRKATVRGAEFNWQQQLAFLPGALDGLLVGASGTWLDTKFDAGIDGREGEDFMLPRASKHVYSAHIGYEKYGLSTRLAAVYRSEYLDTVGAGRAFDIYVAPNTQLDFSLDYKFTPRISMYFEAQNLLDKPLELYQGTRSRTLQMEEYGRTYAIGLKVAL
>NZ_CP018756.1|WP_079221521.1|1345249_1345882_-|uracil-phosphoribosyltransferase
MKIVEVRHPLVQHKIGLMRNAALSTKDFRELANELGTLLAYEATADLETEPHTLPGWAGPVTVQRIAGAKITVVPILRAGLGMLSGVLSLIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGIEAVKAAHPDVEIYTAAIDAQLNDKGYILPGLGDAGDRIFGTRVV
>NZ_CP018756.1|WP_079221520.1|1344715_1345195_+|SRPBCC-family-protein
MTADADQHPDTDLVISRVLAAPRAAVWRAWTEPDLLRQWWCPRPWTTEVRAFELRAGGAFHTFMQGPEGGSSDNPGCFVEVVPQQRLVFTSMLGGGWRPQTPWLGFTAIITLADEGQGCRYTAQVMHPDKTVRDQHEQMGFFEGWNMAIDQLEALAAGL
>NZ_CP018756.1|WP_079221529.1|1355839_1356565_-|SDR-family-oxidoreductase
MSLSRTILITGASSGIGAGIARALAQPGVRLVLGARRLDRLQALAEELRGQGAQVQVQALDVTQRAQVEAFAAMALAEFGSIDVIVNNAGVMPLSPMASLKVDEWDRMIDVNIRGVLYGIAAVLPHMQARGQGQIINIASIGALSVVPTAAVYCATKYAVRAISEGLRQEHRDLRVTCIHPGVVESELADTITDPVAAEAMVQYRAIALQPDAIGRAVRFAIEQPGDVDVNEIVVRPTAAG
>NZ_CP018756.1|WP_079221530.1|1356682_1357567_+|LysR-family-transcriptional-regulator
MSVDLNALAVFQRVAECRSFTGAAEQLGVTRSAVSQTISKLEQALGIALVLRTTRSVNLTDAGQALLSSVRPALAELDTALEATQRRQAAVSGQLRLAVSSIAEAFLAGPMLASFAARHPALQLDITVSDEEFDIVGAGFDAGVRLGEVIAQDMVAVPVSARQRQLVVCAPAYRDQHALPTHPRELADHRCIGWRSAPGKAPYRWEFEERGREFSVDVQPEITSNDMGVMARLAVAGAGIAIGMEETWRPWLQRGELVPLLEPYCPRFAGFFLYYPSRRQAEPKLRALVEHVLG
>NZ_CP018756.1|WP_079221531.1|1357608_1358637_-|LysR-family-transcriptional-regulator
MSHDLNETLIFVKVVEQGSFIAAAKSLGLPKTTVSRKVQELETRLGARLLHRTTRRLGLTEAGSIYHEHCQRIARELEEAESAVSQLQSGPRGWLRFTVPYSIGITWIAPLLGQFHAQYPEIRLDMHLGNEKLDLIAGEADLALRVGALPDSNLVARKLGSLRTQVFASPAYIERYGEPLHPEELQFHRILAMRKPYHTGNSPRFTWQLGENGGELRDFPVTPLMTANDMSALNGALVCGEGLLLTGDVMAKPFVESGMVRRVLAGWTGPEVDFNAVFAGGRLVSPKVRAFVDFLVEKLNFDANYMLAQCPAAKLARQQQEKEDAALESSGKRILEKVTAAA
>NZ_CP018756.1|WP_079221532.1|1358783_1359011_+|hypothetical-protein
MSLRNILAHFRRAGQNALDLAMTVEARPSSLVHKDFREFTAPMRNQRGSSIRLAAHQGDRLRRIGTIPDLGGNVP
>NZ_CP018756.1|WP_079221533.1|1359007_1359778_+|SDR-family-NAD(P)-dependent-oxidoreductase
MNGILTPEVLVLGGTGAVGQGVVGALLEAGSPVLVVGRDPGRLAALHEQFADEPGLQTMLGSLSDDGSAKVLAERVAQRPRPLAAVVAAMGGPYNRGRVIDRSGDALLGAMQADLMPHAHAVRHLLPLLQDNPHARRYVMIGSPAGAKPWAGYGETSITTAALRMYAQVVHQEAQALGVRAQMLEVCSPVCTPANAANACIEWPSSLLVGRRVVSLLDGCRDNRAIVRCDNSDAELPRGLLNLDLPPLWRDTAGVA
>NZ_CP018756.1|WP_079221534.1|1359869_1361093_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MTSPNTTSHRFSHRLTMAGVSILAAAVLAACSGGHAEEAGAPPPPQVSAAPVLVKPISQWDEFSGRVEAVQSVELRPRVSGYIDKVNYVEGEEVKKGAVLFTIDARSYQAEYDRAAAELARARTQASLARSESERAKRLSEQQAISTETAEQRRAAADQSGAAVQAAQAALDAARLNLEFTKVRAPIDGRAGRAMVTAGNLVTAGDSASVLTTLVSLDTVFVYFDADESTFLRYAQMARKGERPSERDSELPVKVGLSGEEGYPHTGKVDFLDNQVARSTGTIRVRALLDNADRQFTPGLFARVQLLGSGQFQAMLIDDKAVLTDQDRKYVYVVDKDGKAQRRDIQLGRTAEGLRIVQSGLAAGDKVIIDGVQKVFMPGMPVQAKAVAMQPSPVPAPGRDATAALNQ
>NZ_CP018756.1|WP_079221535.1|1361220_1364391_+|multidrug-efflux-RND-transporter-permease-subunit
MDFSRFFIDRPIFAAVLSIVIFAAGLISIPLLPIGEYPEVVPPSVVVRTVYPGANPKVIAETVATPLEEAINGVEGMMYLKSVAGSDGVLQMTVTFRPGTDPDAAAVKVQNRVAQAQARLPEDVRRQGVTTQKQSPTFLMVVHLTSPNGKYDTLYLRNYARLHVKDALARIPGVGDAQIFGGGDYAMRAWLDPDKVASRGLTASDVVRAMREQNVQVSAGQLGAEPLPNSQFLTLINAQGRLKSEKEFGDIVLKSGTDGEIVRLSDVARVELGAGDYTLRSQLDGKNAVGIGIFQSPGANALEIRDAVIGTMDEMQKTMPADVKYEAVYDTTIFVRDSIKAVVSTLLEAIALVVLVVILFLQTWRASIIPLIAVPVSVVGTFAALYLLGFSINTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLTPLVAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAARLLKPHDAAKDAPTRIIDRLFGWVFRPFNRFFKSSSEKYERGVSKILGRRGAVFVVYAILLIGTGVIFKLVPPGFIPTQDKLYLIAGVKLPEGSSIARTDEMLRKVAKIAQETDGVAHTISFPGLNALQFTNTPNTGVAFIPLKPFNERHGRTAAQINAEINQKIAGLQEGFAFALMPPPILGLGNGNGYQMFIEDRGNLGYGALQNAVQSMQGAVAQTPGMAFPISSYQANVPQLDAEVDRVKAKAQGVQLTELFDTLQTYLGSAYVNDFNQFGRTWQVIAQADGPFRESVEDISKLRTRNDRGEMVPIGSMVTIKQTFGPDPVLRFNGYPAADLAGEADPRLLSSAEAMNKLTEIADKVLPVGMTTEWTDLSYQQATQGKAAFIVFPVAIMLAFLVLAALYESWSLPLAVILIVPMTLLSALFGVWMTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEMGGKGIVESALEACRLRLRPIVMTSIAFIAGTVPLVLSHGAGAEVRSVTGITVFAGMLGVTLFGLFLTPVFYVALRKFVTRNGGGQLVQHGEPTIHH
>NZ_CP018756.1|WP_079221536.1|1364454_1365192_+|SDR-family-oxidoreductase
MNTHQNKIALVTGATRGIGLETVRQLAQAGVHTLLAGRKRETAVEQALLLQGEGLPVEAIQLDVTDAASIAEAVEQVRQRHGRLDILVNNAGIMIENPAQAPSEQSLETWHRTFDTNVYALVAVTQAFLPLVKQAKSGRIVNVSSMLGSQTLHADPNSGIYDFKVPAYNASKAAVNSWTLALAYELRNTPIKVNTVHPGYVKTDMNGGNGEIEISEGARSSVEMALIGEAGASGSFTYLGEVLPW
>NZ_CP018756.1|WP_079221537.1|1365185_1366607_+|efflux-transporter-outer-membrane-subunit
MVIRTLAMAISSLVLAGCVSVGPNYKAPAQEPVVLQGAQEAVFSTASPVASWWAQFDDPVLEELVHGALSENLDLRVAVARVSQARAVFVESRFDQAPHVTAGGSYDRRKQPDPQLGGQRVFSESYQLGFDAGWELDLFGRKRRAAEAARADLGAEHANLADAQVLVAAEVARNYFELRGTQKRIAVAQHTLENLRDTQKLTEARWELGAGSELDVQSSRARLKAIEADIPLLEVSEAQSRNRLAVLLGQRPEVLTAMLAPQDVPAFAKALPLGDTRELLRQRADVRVAERRLAAATARVGVATADLFPRLSLSGFVGFLGGDASGLVNGNNKAWSLTPSLSWAAFDFGTVRARLRASKAEAEGVAAQYEQAVLLALEDTENALTRYSKQQARLAIVVEQAQAARRAESLAQIRFREGSEDFLTLLDAQRTQLAADDALAAAEAEVNVSVVGVYKALGGWGQSPQAPSVAQAQ
>NZ_CP018756.1|WP_079221538.1|1366674_1367532_-|endonuclease/exonuclease/phosphatase-family-protein
MLSRLRRPALCALLALALPAAAWAAQPPAPLKVMSFNVRTPADTEPGKRWDDRRDVMVKVILDAHPAVVGTQELVQEQATYLAAHLPGYRWFGEGRRGGEGDEHMGVFYDSKVLAIEESGNFWLSDTPDVPGSITWGNLYPRMVTWALFRRLDDGRRFYFMDTHLPYRDEDEPRRIKGAELIAKRLDTLPADLPVVLTGDFNTEPGSETYKAFTRVLQDTRTQVKAPKGPRETFHDFTGKATVQLDWVLVRGFHARSFTTDDRRIGGVLPSDHFPLVVELDWPKR

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Crispr_ID: NZ_CP018756_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_5

1445077-1445220

Unclear

Consensus_repeat	Method
GGTAGAGTCGACCGTTGGTCGGC	CRISPRCasFinder

2 spacers

cas3

The CRISPR arrays of NZ_CP018756_5

>merge|NZ_CP018756|5|1445077-1445220|CRISPRCasFinder
GGTAGAGTCGACCGTTGGTCGGCCATGTGCCTTGGTAGAGTCGACCGTTGGTCGACCATGCGCCTTGGTAGAGTCGACCGTTGGTCGACTATCGCGCAGCGCGGGCCTGCCCCCAGATCGAAGAACAGTCGACCAACGGTCGAC

>NZ_CP018756|5|5|1445077-1445220|CRISPRCasFinder
GGTAGAGTCGACCGTTGGTCGGC	CATGTGCCTTGGTAGAGTCGACCGTTGGTCGACCATGCGCCTT
GGTAGAGTCGACCGTTGGTCGAC	TATCGCGCAGCGCGGGCCTGCCCCCAGATCGA
AGAACAGTCGACCAACGGTCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221594.1\|1436377_1436764_+\|4-carboxymuconolactone-decarboxylase	unknown	unknown	gnl\|CDD\|131478
NZ_CP018756.1\|WP_079221609.1\|1457633_1458164_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP018756.1\|WP_079221605.1\|1448375_1449533_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP018756.1\|WP_079221606.1\|1449529_1453054_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079221595.1\|1436844_1437699_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|131484
NZ_CP018756.1\|WP_079221611.1\|1459226_1460264_-\|agmatine-deiminase-family-protein	unknown	unknown	gnl\|CDD\|377332
NZ_CP018756.1\|WP_079221602.1\|1445269_1447153_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236861
NZ_CP018756.1\|WP_079221598.1\|1441151_1442528_-\|ATP-dependent-RNA-helicase-DbpA	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236977
NZ_CP018756.1\|WP_079221600.1\|1443020_1444100_-\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP018756.1\|WP_079221591.1\|1433548_1434112_+\|protocatechuate-3,4-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|239546
NZ_CP018756.1\|WP_079221599.1\|1442685_1442958_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221608.1\|1456408_1457641_-\|TraB/GumN-family-protein	unknown	unknown	gnl\|CDD\|224828
NZ_CP018756.1\|WP_079221596.1\|1437800_1440224_-\|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family	unknown	unknown	gnl\|CDD\|274418
NZ_CP018756.1\|WP_079221604.1\|1447779_1448169_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|225418
NZ_CP018756.1\|WP_079221607.1\|1453050_1456125_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079221610.1\|1458178_1459066_-\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143597
NZ_CP018756.1\|WP_079221593.1\|1435569_1436355_+\|3-oxoadipate-enol-lactonase	unknown	unknown	gnl\|CDD\|131480
NZ_CP018756.1\|WP_079221603.1\|1447308_1447770_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP018756.1\|WP_079221592.1\|1434202_1435546_+\|3-carboxy-cis,cis-muconate-cycloisomerase	unknown	unknown	gnl\|CDD\|181627
NZ_CP018756.1\|WP_079221597.1\|1440522_1441062_+\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221594.1\|1436377_1436764_+\|4-carboxymuconolactone-decarboxylase	gnl\|CDD\|131478	TIGR02425, putative_gamma-carboxymuconolactone_decarboxylase, 4-carboxymuconolactone decarboxylase. Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other].	1.34755e-65
NZ_CP018756.1\|WP_079221609.1\|1457633_1458164_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	3.06076e-58
NZ_CP018756.1\|WP_079221591.1\|1433548_1434112_+\|protocatechuate-3,4-dioxygenase-subunit-alpha	gnl\|CDD\|239546	cd03463, 3,4-PCD_alpha, Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion bound in the beta-subunit at the alpha-subunit-beta-subunit interface. 3,4-PCD is a member of the aromatic dioxygenases which are non-heme iron intradiol-cleaving enzymes that break the C1-C2 bond and utilize Fe3+.	4.15492e-88
NZ_CP018756.1\|WP_079221605.1\|1448375_1449533_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.34255e-92
NZ_CP018756.1\|WP_079221606.1\|1449529_1453054_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079221595.1\|1436844_1437699_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|131484	TIGR02431, p-hydroxybenzoate_hydroxylase_transcriptional, beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family. Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions].	2.36746e-105
NZ_CP018756.1\|WP_079221602.1\|1445269_1447153_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NZ_CP018756.1\|WP_079221598.1\|1441151_1442528_-\|ATP-dependent-RNA-helicase-DbpA	gnl\|CDD\|236977	PRK11776, PRK11776, ATP-dependent RNA helicase DbpA; Provisional.	0
NZ_CP018756.1\|WP_079221603.1\|1447308_1447770_-\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	1.27766e-19
NZ_CP018756.1\|WP_079221600.1\|1443020_1444100_-\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	6.93414e-103
NZ_CP018756.1\|WP_079221610.1\|1458178_1459066_-\|carbon-nitrogen-hydrolase	gnl\|CDD\|143597	cd07573, CPA, N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53, also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine, a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA, also known as nitrilase-like 1 (NLP1), and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer; P. aeruginosa AugB is a homohexamer, Arabidopsis thaliana NLP1 is a homooctomer.	4.25987e-177
NZ_CP018756.1\|WP_079221608.1\|1456408_1457641_-\|TraB/GumN-family-protein	gnl\|CDD\|224828	COG1916, COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown].	5.20671e-137
NZ_CP018756.1\|WP_079221596.1\|1437800_1440224_-\|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family	gnl\|CDD\|274418	TIGR03074, PQQ_membr_DH, membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family. This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.	0
NZ_CP018756.1\|WP_079221604.1\|1447779_1448169_-\|c-type-cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	3.16325e-14
NZ_CP018756.1\|WP_079221607.1\|1453050_1456125_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079221593.1\|1435569_1436355_+\|3-oxoadipate-enol-lactonase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	9.07972e-107
NZ_CP018756.1\|WP_079221611.1\|1459226_1460264_-\|agmatine-deiminase-family-protein	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	2.7198e-150
NZ_CP018756.1\|WP_079221592.1\|1434202_1435546_+\|3-carboxy-cis,cis-muconate-cycloisomerase	gnl\|CDD\|181627	PRK09053, PRK09053, 3-carboxy-cis,cis-muconate cycloisomerase; Provisional.	0
NZ_CP018756.1\|WP_079221597.1\|1440522_1441062_+\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	2.46434e-85

>NZ_CP018756.1|WP_079221600.1|1443020_1444100_-|YeiH-family-putative-sulfate-export-transporter
MNASTLSPWSLPALRQRWQPRLPGLLLVGLVAAASLSLAELPWLQAHGLSALTVAIVAGIVVGNTFYPRLAPGSAAGVGFSKHWLLRAGIVLYGLRLTFQDIGHVGVAGVAMDALVVASTFGLACWLGVRVFRMDREAAMLIGAGSAICGAAAVMAAEPVVRGRAAQVTVAVSTVVVFGTLAMFLYPALYALVQSHGLLAMDARQYGLFTGATMHEVAQVVAAGRAVSESAADTAVITKMVRVMLLAPFLVVLSLWLARGGKAAADGSTPRIVVPWFAFGFVAVAGFNSLHLLPAGVQAGLVQLDTVLLAMAMAALGLTTHVSALRQAGLKPLLLASILFAWLLLGGLAIHQGVLAVLG
>NZ_CP018756.1|WP_079221599.1|1442685_1442958_-|hypothetical-protein
MTASPALLPIPLRLLDDRYGPGNADEAEDTLIGIVQAVMGVRATCSFDFDTRHANPWFHQLLLGPQADGHPATPAQLQAMAVRLAAIGLG
>NZ_CP018756.1|WP_079221598.1|1441151_1442528_-|ATP-dependent-RNA-helicase-DbpA
MTDFSTLPLSPALQPGLDALGYTTLTPIQAQSLPAILDRCDVIAQAPTGSGKTAAFGLGLLQAIDPSLIRVQALVLCPTRELADQVAKQIRKLATGIPNLKLLLLVGGVPLGPQLASLEGHDPHVVVGTPGRVQELARKRALNLGAVRTLVLDEADRMLDMGFEEPIREIAGRTHKDRQTLLFSATFPDSIREIARDLLRDALEVTVEGADQAPAIRHLFCEVEPAHRQKALAGLLLKYTPESAVVFCNTRKDVDEVANSLQQFGFSALALHGDMEQRDREEVLLRLANRSCNVLVASDVAARGLDVEELAAVINYELPTDVESYQHRVGRTGRAGASGLAISLVAGREKTRAEAVEAHLGQPLDWQKTPLATSRPAELPQAAMRTLRIDGGKTDKLRPGDILGALTGDAGLSGKHIGKIAIFPTRSYVAIAREQVNKAVAKLEAGKIKGRRFRVRMM
>NZ_CP018756.1|WP_079221597.1|1440522_1441062_+|adenine-phosphoribosyltransferase
MTDATVAVPAWASRLRDIADFPKPGILFKDIMPLLAHGEDFRGAISAMADRWRGQQLDAIVGIESRGFILGAAMALELGVGFVPVRKPGKLPGKVLREEYTLEYRSDCIEVHADALPAGARVAIIDDVLATGGTLGAALSLVRRLGVEVVGAGVLVELDGLGGRARWEAGLPLHTELVF
>NZ_CP018756.1|WP_079221596.1|1437800_1440224_-|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family
MDETTKVPALCRVLVVLLGILVTLFGLALLVGGVRLVQLGGSWYFLLMGAVSAVAGVLLAMRRPNGALLYGLAFVATLAWALVDAGWEFWPLVSRLVMPAVLALLVALAWPVLRRSRGQAAGRGAYGVAAVLLVGLLGTAVSAFQPRPVQTAQGTTPPVVPVAKGAEQRDWMHWGNTTAGTRFAALDQITPANVKELQVAWTAHTGDVPESNGFGAEDQNTPLQIGDTLYLCTPHNQVIAIDADSGKQRWAFDPKATAPNWQRCRGLGYFDAATAPAAATAAAPAPAPMPATETASAGPALCEKRILMTSIDARLFALDAKTGALCPDFGSNGVVDLKTGMGEIKPGFYTLTAAPLVAGELIVVGGRVADNIEVGEPSGVVRAYNVRTGALAWVWDLSKETPDVPLDPSIHYTRATPNVWTSMAYDPQLGLVYLPTGNTTPDQWAGERTPQDDKYSSAVVALDVATGKERWVYQTVHHDLWDYDLPAQPTLTDVPDGKGGTLPALLQITKAGQIFMLNRQTGVPISEVRNIPAPQGNAQGERYAATQPLSVGLPQIGAQTLTESDMWGATPIDQMLCRIQFKQFRYDGMYTPPGEDLALQWPGSLGGMNWGSASIDPTTGYLFVNDMRLGLWTKLIPRAQMTSGDGGVEMGAASQTGTPYGSLRDRFLSKLGIPCQKPPFGTMSAINLATRQLVWQVPVGTVKDTGPMGIKMGLPIPIGMPTLGGSLATQSGLLFFAGTQDYYLRAYDSRTGEEVWKARMPVGSQGTPMTYVSPKTGRQYVVISAGGARQSPDRGDYVIAYALPERK
>NZ_CP018756.1|WP_079221595.1|1436844_1437699_-|helix-turn-helix-domain-containing-protein
MPAVPPSRRPKRPPAPPQDRGLAHELMQQIQDNQGDPDFMTSLGRGLAVLSVFSQHPREVTMSQISTDTGISRAAVRRVLYTLEKLGYVGEQGRGFVLLPRVLGMGGAYVASSSMTAAAQPVLDALRDDVHESCSLGVLDGDDILYVARAETVRIMSIGLRAGSRLPAYCTSMGRVLLAALPRDTLEGYLERNPLRPRTDRTVTRMDDFLDLLEKVRREGVSLVDQELEIGLRSIAVPVRSRSGDVVAALNIGTQAGRIGLGVMQTQLLPRLREAAQRLGTLLN
>NZ_CP018756.1|WP_079221594.1|1436377_1436764_+|4-carboxymuconolactone-decarboxylase
MDEQERYEAGLAVRRQVLGEAHVDRSLQARTEFTTEFQDFITRTAWGTVWTREGLPRHTRSLLTIVMMVALGHDEEFKLHIRAARNNGVTPEEIKEVLLQAAIYCGVPAANHAFALAKPILEEQASEG
>NZ_CP018756.1|WP_079221593.1|1435569_1436355_+|3-oxoadipate-enol-lactonase
MPFLDLPQHRLHYQTEGRADGPWLTFCNSLGTDLGMWQPQVDALATQYRILRYDRRGHGQSSAPPGLYTVAELGADVLALWDHLGIERSHFCGLSIGGLTGQWLGVHAGNRLRTLTVAATAAKIGTLDGWQARIAQVLHDGLLPLVDGTRERWFTAAFAQTHASQVEDILQRFLATSVAGYAGCCNAVGMADFRDVLGRIGVPLLAIAGDDDPVCVPAELQAIADGVAVGHFATVPGRHICNLESPQAFTAALVAHLSAQH
>NZ_CP018756.1|WP_079221592.1|1434202_1435546_+|3-carboxy-cis,cis-muconate-cycloisomerase
MSHSPTLLGGLFGDPAVDAVFSDEARLQAMLDVERALARAQVQCGVIPAAVLAPIEAACSADLYAVPALSAATALAGNPAIPLVKALTAQVKANDADAARWVHWGATSQDIIDTGAVLQLRAAVNHVQARLQVLCRALARLAEAERGTGLPGRTLLQQAVPVTFGLKAAGWLDALQRSQRRLDALADDTLVLQFGGAAGTLASLQARGLDVAEALAAELQLPLPALPWHTARDRIAEFGSVFALLTGSLGKIATDIVLLMQSEVAEAFEPAGEGKGGSSAMPHKRNPVGCVAAIAAATRVPGLLSTLFSALPQPHERAAGQWHAEWDTVPEIVRLCAGSLAQVSVVVQGLQLDRGRMRQHLDSHGGLLYAEAVAVTLGERIGKPAAHALVEHAAKQALAQSLHLREVLAQTPEVAAQLSTAQLDALFAADSWRGMADTWIDRVLARG
>NZ_CP018756.1|WP_079221591.1|1433548_1434112_+|protocatechuate-3,4-dioxygenase-subunit-alpha
MSFQSTPWQTVGPYYRLGLEPLYRTEIAPATAQGERVEVQGQVFDGNGVPVSDAVLEIWQADAQGIYAHGEDPRRGDHDPAFDGWGRVPTDDQGRFAFTTVKPGRVPGLRGEPQAPHLVVLVFMRGLLQATRGRIYFSDEASNGEDGILALVPAERRHTLVAQAQGKGLYHWDVRMQGPDETVFFAY
>NZ_CP018756.1|WP_079221602.1|1445269_1447153_+|ATP-binding-cassette-domain-containing-protein
MPLITLQNVDFSVGGPLLLEKAELSIEPGERIALIGRNGAGKSTLLKLLSGDHKPDDGEVRVQQGVRVTRLEQEVPHGAAGSVFDVVADGLGELGQWLAEFHHLSHAEVFDGEALGNVQAKIDAANGWGLDQRVSETLTKLDLDGEAEFGRLSGGMKRRVLLARALVSSPDVLLLDEPTNHLDIEAIDWLEAFLKGWSGSVVFVTHDRRFLRALATRIVEIDRGQVTSWPGDWANYERRREERLNAQAQENARFDKLLAQEEVWIRQGIKARRTRDEGRVRRLKAMRNERSQRRDLSGNVKMEAAQGVSSGKKVIDVKDVSFAFGERTMVRDFTTTILRGDRIGLIGPNGSGKTTLLKLLLGELQPAKGEVNAGTNLQIAYFDQYRAVLREDWSAIENVAEGRDFLEFNGKRKHVHAYLQDFMFTPERARAPITRLSGGERNRLLLAKLFAQPSNLLVMDEPTNDLDVETLELLEELLGEYTGTLLLVSHDRDFIDNVVTSTLVMEGDGVIGEYVGGYTDWQRYAASVATPAAAPATKPAAAAPAVAAAAAPAAPKRKLAYKEARELEQLPKTIEKLEGDVEGLTAAMNDPSFYTRSSAEVTAHTQQLAKVQAELDAAYARWEELEG
>NZ_CP018756.1|WP_079221603.1|1447308_1447770_-|cytochrome-c
MSKAAHTMRHAIALSVALLLAACSQSQVESSEKSAGDPGHASGEHGSSSSAGLPPGREAAGEARAKVKGKATNQSCIDCHGADGNAPIDPTYPKLGGQYGDYLAHALQAYRAGDRQHALMTPQAKDLSDQDIADLAAYFGSRPSQLRDLHGVK
>NZ_CP018756.1|WP_079221604.1|1447779_1448169_-|c-type-cytochrome
MRPQPLAACLALAVLLPLGAAAQPAPAPAAPAPAPAQASPPAAAAPAGNFDNGRVLAYTCQGCHGITGYKNAYPSYRVPKIGGQTQQYLTQALTEYRQGKRRHPTMQAQSMSFSEQEIADLAVYLSTVK
>NZ_CP018756.1|WP_079221605.1|1448375_1449533_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MSHPTFLPGRRTGLCAAALLISTSLLLGGCAAGPNSEAKAAETKDEKKVDAVPVEVAVASHRAVAASYTGTAALEPRAESQVVAKTSGVALAVLVEEGQRVTAGQPLVRLDPDRARLAVAQSEAQMRKLENNYQRAQKLVGQQMVSASDVDQLRYDLENMRAQYRLATLELSYTTVVAPISGVIASRSIKTGNFVQINTPIFRIVDNSQLEATLNVPERELATLRAGQPVVLSADALPGKTFTGTVDRIAPVVDSGSGTFRVVSAFNGTEHALQPGMFGRIRIDYDQRADALVVPRLAILDDGEPAVFRVREGKVARVPVKLGYAEGPWVEIREGLAAGDRIVTAGKVALRDGTAVQVIADPKAPKAKPATVAAGKSADKAGSQQ
>NZ_CP018756.1|WP_079221606.1|1449529_1453054_+|efflux-RND-transporter-permease-subunit
MSAPGHDHGASPGGDGAAAGLRGGLVEFATRRRVTIAMCTVTLLLFGLIALGNLKVNLLPDLSYPTLTVRTEYTGAAPTEIESLITQPVEEAVGVVKNLRKLKSVSRTGQSDVVLEFAWGTNMDQASLEVRDKMEALNLPLEAKAPVLLRFNPSTEPIMRLVLSTKAAPTSDEDAIRELTGLRRYADEDLKKKLEPVTGVAAVKVGGGLEDEIQVDIDQQKLAQLNLPIDTVIKRLKEENINISGGRLEEGSQRFLVRTVNQFADLEEIRNLLVTTQSSNGSAADSALQQMFNIAASTGSAAAVAAASAAQSASSGGGSSVVANGVPVRLKDVATVRQGYKEREAIIRLGGKESVEVAIYKEGDANTVATAEALRKRLEQIKATFPGDAELTTIEDQSRFIEHAISDVKKDAVIGGLLAILIIFLFLRDGWSTFVISLSLPVSIIATFFFMGQLGLSLNVMSLGGLALATGLVVDDSIVVLESIAKARERGLGILQAAIVGTREVSMAVVASTLTTIAVFLPLVFVDGIAGQLFRDQALTVAIAIAISLLVSMTLIPMLSSLKGRPPLAFPEEAAAEPWHPQSRWQKPVALGRRGFVASVRWSFFALAWLVVRLWRGVVAVVGPVMRKASDIAMKPYAGAERGYLRLLPNALAHPGKVLGLAALAFVGTMALVPMLGADLIPQLAQDRFEMTVKLPAGTPLKQTDALVRELQLAHGQGEGVASLYGVSGSGTRLDASPTESGENIGKLTVVMEGGGNARTEAEITERLRDTMGQHPGAQVDFARPALFSFSTPLEIELRGQDMATLEQAGQRLAALLRSNAHYADVKSTVEEGFPEIQIRFDQERAGALGLTTRQIADVVVKKVRGDVATRYSFRDRKIDVLVRAQEGDRASVDSIRRLIVNPGSSRPVTLDAVADVVATTGPSEIHRADQTRVAVVSANLRDIDLGAAMREVQQMVAEQPLGAGVGLHIGGQGEELAQAAKSLIFAFGLAIFLVYLVMASQFESLLHPFVILFTIPLALVGAILALLMTGKPISVVVFIGLILLVGLVTKNAIILIDKVNQLREAGVAKHEALVEGARSRLRPIIMTTLCTLFGFLPLAVAMGEGAEVRAPMAITVIGGLLVSTLLTLLVIPVVYDLMDRRGDAYYRERGRKHAGEGLHAAEAGPSGGAEEPA
>NZ_CP018756.1|WP_079221607.1|1453050_1456125_+|efflux-RND-transporter-permease-subunit
MSVAEFSIRRPVTTIMCFVSLVVVGLIASFRLPLEALPDISAPFLFVQIPYTGSTPEEVERTIIRPVEESLATMTGIKRMRSQATSEAASIFIEFSDWDRDIAIAASDARERIDAIRSDLPDDLQRYNVFKWSSSDQPVLKVRLASATDLTAAYDMLDREFKRRIERIPGVARVDITGAPPNEVEIAIDPDRLSAHGLSINELSDRLRTLNFSISAGQINDNGQRVRVQPVGEITDLQEMRDLVINAKGLRLGDIAEVRLKPARMNYGRRLDGNPAIGLDIFKERSANLVDVSRAALAEVEAIRAQDSMRDVQIKVIDNQGKAVTSSLLELAEAGAVGLILSVTVLFFFLRHWPSTLMVTLAIPICFTITLGFMYFAGVTLNILTMMGLLLAVGMLVDNAVVVVESIYQERERMPGQPRLASIIGTRNVAIALSAGTLCHCIVFVPNLFGETNNISIFMAQIAITISVSLLASWLVAVSLIPMLSARMATPKLLHSQTGVIARLQRHYARLLDWSLRHRGWSLLGIVLVVLVSLVPMKLTKVDMFGGGGGKDVFIGYMWKGAYTYRQMSEEVGRVEAWVEQNRERLHVQQVYSWYSEQEGGSTTVTIDEKYAKDIKALQEEIRKGLPKSARADYFIGNQGGDGGGNQGVQVQLVGDSSSMLQEIGQEVLPLLAQRPELRDVRIDNGEKGGELKVHVDRERAAAFGFNAEQVASFVGLALRGAPLREFRRGDNEVPVWVRFAGAEQSSPEDLASYSVRTGDGRSVPLLSLVSVDVGSSATQIGRTNRQTTLTIKANLAEKITAPDGRKAIEAVLKPMSFPAGYGFTFDGGDYGNDNEAMQQMVFNLLIALVMIYVVMAAVFESLLFPAAIMSGVLFSIFGVFWLFWVTGTSFGIMSFIGILVLMGVVVNNGIVMIEHINNLRRGGMGRTQALVEGSRERLRPIMMTMGTAILAMVPISLTNTQMFGDGPEYAPMARAIAGGLAFSTVVSLLFLPTIYAVLDDLRSAVTRLIRRARGLDKAAATAA
>NZ_CP018756.1|WP_079221608.1|1456408_1457641_-|TraB/GumN-family-protein
MNESMTETLPETGDDLFAGQPVRVVERDGVRYTLLGTAHVSHASVEAVEKAIDSGRFDAVAVELDPQRLQALSDPDTLAKLDLVEVIRKGRVALFAANLALSAYQRRLAEQLGIEPGAELKRAVDLARERGLPVHLIDREVGLTFRRASQRLGFFGKLKLVAGLGAGLFSSEEVGENEIEKLKQGDMLESSFGEFATESPALYETIIGERDRYMATRLREEHNPQLREVLAVVGAGHLAGLARYLETDTAEPAPLRAELEAVPKKRNIPWLTLIILAIVITGVAVGFYRGGLGVGTELLATWAMYTGGLAGIGCLLAGSHPLSILTAIAVAPFKPFRLSIPTGAFSALVEARLRKPAYEDFLKLRDDAQSLKGWYRNRVTRVVLTFMLTNLGSMLGLWLTAGKVWGKVAG
>NZ_CP018756.1|WP_079221609.1|1457633_1458164_-|N-acetyltransferase
MAVLIRDAGPADIAAITAIYAVEVTDFVNTYEYDIPDQDEMLRRMRDIIDRGFPYLVAEIDGQVAGYAYANTYRTRVAYQWTVENSVYVDAAYQGKGVGTGLLQALIDACVARGYRQMVAVIGEPTNTASIKLHERFGFHLVGVFKGLGRKHGRWLDTVQMQRALGDGADTAPSNE
>NZ_CP018756.1|WP_079221610.1|1458178_1459066_-|carbon-nitrogen-hydrolase
MNSRSPLTVALIQERNHGDAAANLAVIEARVAEAAAQGAKLVLLQELHNGPYFCQHESVDEFDLAEPIPGPSTERLGALAKKHGVVLVGSLFERRAAGLYHNTAVVFEKDGTLLGKYRKMHIPDDPGFYEKFYFTPGDIGFTPIDTSVGRLGVLVCWDQWYPEAARLMALAGAELLLYPTAIGWDPDDVQDEKTRQRDAWVLSHRGHAVANGLPVLSCNRVGHEASPLGASGIQFWGNSHVLGPQGEFLAEAGTDATVLVCDVDLQRSEHVRRIWPFLRDRRIDAYGDLLKRYID
>NZ_CP018756.1|WP_079221611.1|1459226_1460264_-|agmatine-deiminase-family-protein
MNQTLRFPAEWEAQSGVLIAWPTADTDWADRLGQVEETYIALVAAITRFQPVLICVADDDVETYAEMRLRSNRIDMDRVRFTTAAYDDTWLRDSGPITLRRADGSFQLLDFRFTGWGGKFDATLDDQLVGALDQAGVFNDAPVRSIPFALEGGGIETDGEGTLLTTWKCLHERHPDRDRASLSADLGDWLQQDRVLWLDHGYLEGDDTDAHIDTLARFASPDSIVYQACDDESDSHYDELQAMGNELAALRTKDGQPYRLFPLPWAQPVMDEGRRLAASYANYLIVNGAVLMPAYGDPADDLARDVLAQAHPGREIVQVPCRSLIWQNGSLHCITMQLPAGLLKA

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Crispr_ID: NZ_CP018756_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_6

1447167-1447255

Unclear

Consensus_repeat	Method
GTGCGGACCAACGGTCCGCACCTACC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP018756_6

>merge|NZ_CP018756|6|1447167-1447255|CRISPRCasFinder
GTGCGGACCAACGGTCCGCACCTACCGGTAGATCCACGCCATGCGTGGATGGGTGATCCGTCAGTGCGGACCAACGGTCCGCACCCACC

>NZ_CP018756|6|6|1447167-1447255|CRISPRCasFinder
GTGCGGACCAACGGTCCGCACCTACC	GGTAGATCCACGCCATGCGTGGATGGGTGATCCGTCA
GTGCGGACCAACGGTCCGCACCCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221594.1\|1436377_1436764_+\|4-carboxymuconolactone-decarboxylase	unknown	unknown	gnl\|CDD\|131478
NZ_CP018756.1\|WP_079221609.1\|1457633_1458164_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP018756.1\|WP_079221605.1\|1448375_1449533_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP018756.1\|WP_079221601.1\|1444202_1445081_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182768
NZ_CP018756.1\|WP_079221606.1\|1449529_1453054_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079221595.1\|1436844_1437699_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|131484
NZ_CP018756.1\|WP_079221612.1\|1460303_1460633_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221602.1\|1445269_1447153_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236861
NZ_CP018756.1\|WP_079221598.1\|1441151_1442528_-\|ATP-dependent-RNA-helicase-DbpA	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236977
NZ_CP018756.1\|WP_079221600.1\|1443020_1444100_-\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP018756.1\|WP_079221603.1\|1447308_1447770_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP018756.1\|WP_079221599.1\|1442685_1442958_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221608.1\|1456408_1457641_-\|TraB/GumN-family-protein	unknown	unknown	gnl\|CDD\|224828
NZ_CP018756.1\|WP_079221596.1\|1437800_1440224_-\|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family	unknown	unknown	gnl\|CDD\|274418
NZ_CP018756.1\|WP_079221604.1\|1447779_1448169_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|225418
NZ_CP018756.1\|WP_079221607.1\|1453050_1456125_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079221593.1\|1435569_1436355_+\|3-oxoadipate-enol-lactonase	unknown	unknown	gnl\|CDD\|131480
NZ_CP018756.1\|WP_079221611.1\|1459226_1460264_-\|agmatine-deiminase-family-protein	unknown	unknown	gnl\|CDD\|377332
NZ_CP018756.1\|WP_079221610.1\|1458178_1459066_-\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143597
NZ_CP018756.1\|WP_079221597.1\|1440522_1441062_+\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221594.1\|1436377_1436764_+\|4-carboxymuconolactone-decarboxylase	gnl\|CDD\|131478	TIGR02425, putative_gamma-carboxymuconolactone_decarboxylase, 4-carboxymuconolactone decarboxylase. Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other].	1.34755e-65
NZ_CP018756.1\|WP_079221609.1\|1457633_1458164_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	3.06076e-58
NZ_CP018756.1\|WP_079221605.1\|1448375_1449533_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.34255e-92
NZ_CP018756.1\|WP_079221601.1\|1444202_1445081_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182768	PRK10837, PRK10837, putative DNA-binding transcriptional regulator; Provisional.	1.05132e-93
NZ_CP018756.1\|WP_079221606.1\|1449529_1453054_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079221595.1\|1436844_1437699_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|131484	TIGR02431, p-hydroxybenzoate_hydroxylase_transcriptional, beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family. Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions].	2.36746e-105
NZ_CP018756.1\|WP_079221602.1\|1445269_1447153_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NZ_CP018756.1\|WP_079221598.1\|1441151_1442528_-\|ATP-dependent-RNA-helicase-DbpA	gnl\|CDD\|236977	PRK11776, PRK11776, ATP-dependent RNA helicase DbpA; Provisional.	0
NZ_CP018756.1\|WP_079221600.1\|1443020_1444100_-\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	6.93414e-103
NZ_CP018756.1\|WP_079221603.1\|1447308_1447770_-\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	1.27766e-19
NZ_CP018756.1\|WP_079221610.1\|1458178_1459066_-\|carbon-nitrogen-hydrolase	gnl\|CDD\|143597	cd07573, CPA, N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53, also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine, a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA, also known as nitrilase-like 1 (NLP1), and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer; P. aeruginosa AugB is a homohexamer, Arabidopsis thaliana NLP1 is a homooctomer.	4.25987e-177
NZ_CP018756.1\|WP_079221608.1\|1456408_1457641_-\|TraB/GumN-family-protein	gnl\|CDD\|224828	COG1916, COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown].	5.20671e-137
NZ_CP018756.1\|WP_079221596.1\|1437800_1440224_-\|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family	gnl\|CDD\|274418	TIGR03074, PQQ_membr_DH, membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family. This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.	0
NZ_CP018756.1\|WP_079221604.1\|1447779_1448169_-\|c-type-cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	3.16325e-14
NZ_CP018756.1\|WP_079221607.1\|1453050_1456125_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079221593.1\|1435569_1436355_+\|3-oxoadipate-enol-lactonase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	9.07972e-107
NZ_CP018756.1\|WP_079221611.1\|1459226_1460264_-\|agmatine-deiminase-family-protein	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	2.7198e-150
NZ_CP018756.1\|WP_079221597.1\|1440522_1441062_+\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	2.46434e-85

>NZ_CP018756.1|WP_079221602.1|1445269_1447153_+|ATP-binding-cassette-domain-containing-protein
MPLITLQNVDFSVGGPLLLEKAELSIEPGERIALIGRNGAGKSTLLKLLSGDHKPDDGEVRVQQGVRVTRLEQEVPHGAAGSVFDVVADGLGELGQWLAEFHHLSHAEVFDGEALGNVQAKIDAANGWGLDQRVSETLTKLDLDGEAEFGRLSGGMKRRVLLARALVSSPDVLLLDEPTNHLDIEAIDWLEAFLKGWSGSVVFVTHDRRFLRALATRIVEIDRGQVTSWPGDWANYERRREERLNAQAQENARFDKLLAQEEVWIRQGIKARRTRDEGRVRRLKAMRNERSQRRDLSGNVKMEAAQGVSSGKKVIDVKDVSFAFGERTMVRDFTTTILRGDRIGLIGPNGSGKTTLLKLLLGELQPAKGEVNAGTNLQIAYFDQYRAVLREDWSAIENVAEGRDFLEFNGKRKHVHAYLQDFMFTPERARAPITRLSGGERNRLLLAKLFAQPSNLLVMDEPTNDLDVETLELLEELLGEYTGTLLLVSHDRDFIDNVVTSTLVMEGDGVIGEYVGGYTDWQRYAASVATPAAAPATKPAAAAPAVAAAAAPAAPKRKLAYKEARELEQLPKTIEKLEGDVEGLTAAMNDPSFYTRSSAEVTAHTQQLAKVQAELDAAYARWEELEG
>NZ_CP018756.1|WP_079221601.1|1444202_1445081_+|LysR-family-transcriptional-regulator
MRLTLRQLQVFVAIADHGSTTAAGQAIALSQSASSAALQELEAHFGTPLFDRIGRRLALNGHGRALLEPARALLVNAADLERQLAAGGDPGQGAPLRLVLAASTTIGNYLLPPRIAALLRQAPQAEVDLRIDNSAGVVAAVQRLDVDAGLIEGPCHERGLQVTPWQQDPLVIVAAPDAPARWSLDELRGARWLLREPGSGTREAVEQALLPHLHGFAQTLQLGNTEAIKQAAIAGLGVACLSRHALEEPLALGRLRVLETPLPLLQRTLWLVRHPGKQWLPGLQALLGEAQR
>NZ_CP018756.1|WP_079221600.1|1443020_1444100_-|YeiH-family-putative-sulfate-export-transporter
MNASTLSPWSLPALRQRWQPRLPGLLLVGLVAAASLSLAELPWLQAHGLSALTVAIVAGIVVGNTFYPRLAPGSAAGVGFSKHWLLRAGIVLYGLRLTFQDIGHVGVAGVAMDALVVASTFGLACWLGVRVFRMDREAAMLIGAGSAICGAAAVMAAEPVVRGRAAQVTVAVSTVVVFGTLAMFLYPALYALVQSHGLLAMDARQYGLFTGATMHEVAQVVAAGRAVSESAADTAVITKMVRVMLLAPFLVVLSLWLARGGKAAADGSTPRIVVPWFAFGFVAVAGFNSLHLLPAGVQAGLVQLDTVLLAMAMAALGLTTHVSALRQAGLKPLLLASILFAWLLLGGLAIHQGVLAVLG
>NZ_CP018756.1|WP_079221599.1|1442685_1442958_-|hypothetical-protein
MTASPALLPIPLRLLDDRYGPGNADEAEDTLIGIVQAVMGVRATCSFDFDTRHANPWFHQLLLGPQADGHPATPAQLQAMAVRLAAIGLG
>NZ_CP018756.1|WP_079221598.1|1441151_1442528_-|ATP-dependent-RNA-helicase-DbpA
MTDFSTLPLSPALQPGLDALGYTTLTPIQAQSLPAILDRCDVIAQAPTGSGKTAAFGLGLLQAIDPSLIRVQALVLCPTRELADQVAKQIRKLATGIPNLKLLLLVGGVPLGPQLASLEGHDPHVVVGTPGRVQELARKRALNLGAVRTLVLDEADRMLDMGFEEPIREIAGRTHKDRQTLLFSATFPDSIREIARDLLRDALEVTVEGADQAPAIRHLFCEVEPAHRQKALAGLLLKYTPESAVVFCNTRKDVDEVANSLQQFGFSALALHGDMEQRDREEVLLRLANRSCNVLVASDVAARGLDVEELAAVINYELPTDVESYQHRVGRTGRAGASGLAISLVAGREKTRAEAVEAHLGQPLDWQKTPLATSRPAELPQAAMRTLRIDGGKTDKLRPGDILGALTGDAGLSGKHIGKIAIFPTRSYVAIAREQVNKAVAKLEAGKIKGRRFRVRMM
>NZ_CP018756.1|WP_079221597.1|1440522_1441062_+|adenine-phosphoribosyltransferase
MTDATVAVPAWASRLRDIADFPKPGILFKDIMPLLAHGEDFRGAISAMADRWRGQQLDAIVGIESRGFILGAAMALELGVGFVPVRKPGKLPGKVLREEYTLEYRSDCIEVHADALPAGARVAIIDDVLATGGTLGAALSLVRRLGVEVVGAGVLVELDGLGGRARWEAGLPLHTELVF
>NZ_CP018756.1|WP_079221596.1|1437800_1440224_-|membrane-bound-PQQ-dependent-dehydrogenase,-glucose/quinate/shikimate-family
MDETTKVPALCRVLVVLLGILVTLFGLALLVGGVRLVQLGGSWYFLLMGAVSAVAGVLLAMRRPNGALLYGLAFVATLAWALVDAGWEFWPLVSRLVMPAVLALLVALAWPVLRRSRGQAAGRGAYGVAAVLLVGLLGTAVSAFQPRPVQTAQGTTPPVVPVAKGAEQRDWMHWGNTTAGTRFAALDQITPANVKELQVAWTAHTGDVPESNGFGAEDQNTPLQIGDTLYLCTPHNQVIAIDADSGKQRWAFDPKATAPNWQRCRGLGYFDAATAPAAATAAAPAPAPMPATETASAGPALCEKRILMTSIDARLFALDAKTGALCPDFGSNGVVDLKTGMGEIKPGFYTLTAAPLVAGELIVVGGRVADNIEVGEPSGVVRAYNVRTGALAWVWDLSKETPDVPLDPSIHYTRATPNVWTSMAYDPQLGLVYLPTGNTTPDQWAGERTPQDDKYSSAVVALDVATGKERWVYQTVHHDLWDYDLPAQPTLTDVPDGKGGTLPALLQITKAGQIFMLNRQTGVPISEVRNIPAPQGNAQGERYAATQPLSVGLPQIGAQTLTESDMWGATPIDQMLCRIQFKQFRYDGMYTPPGEDLALQWPGSLGGMNWGSASIDPTTGYLFVNDMRLGLWTKLIPRAQMTSGDGGVEMGAASQTGTPYGSLRDRFLSKLGIPCQKPPFGTMSAINLATRQLVWQVPVGTVKDTGPMGIKMGLPIPIGMPTLGGSLATQSGLLFFAGTQDYYLRAYDSRTGEEVWKARMPVGSQGTPMTYVSPKTGRQYVVISAGGARQSPDRGDYVIAYALPERK
>NZ_CP018756.1|WP_079221595.1|1436844_1437699_-|helix-turn-helix-domain-containing-protein
MPAVPPSRRPKRPPAPPQDRGLAHELMQQIQDNQGDPDFMTSLGRGLAVLSVFSQHPREVTMSQISTDTGISRAAVRRVLYTLEKLGYVGEQGRGFVLLPRVLGMGGAYVASSSMTAAAQPVLDALRDDVHESCSLGVLDGDDILYVARAETVRIMSIGLRAGSRLPAYCTSMGRVLLAALPRDTLEGYLERNPLRPRTDRTVTRMDDFLDLLEKVRREGVSLVDQELEIGLRSIAVPVRSRSGDVVAALNIGTQAGRIGLGVMQTQLLPRLREAAQRLGTLLN
>NZ_CP018756.1|WP_079221594.1|1436377_1436764_+|4-carboxymuconolactone-decarboxylase
MDEQERYEAGLAVRRQVLGEAHVDRSLQARTEFTTEFQDFITRTAWGTVWTREGLPRHTRSLLTIVMMVALGHDEEFKLHIRAARNNGVTPEEIKEVLLQAAIYCGVPAANHAFALAKPILEEQASEG
>NZ_CP018756.1|WP_079221593.1|1435569_1436355_+|3-oxoadipate-enol-lactonase
MPFLDLPQHRLHYQTEGRADGPWLTFCNSLGTDLGMWQPQVDALATQYRILRYDRRGHGQSSAPPGLYTVAELGADVLALWDHLGIERSHFCGLSIGGLTGQWLGVHAGNRLRTLTVAATAAKIGTLDGWQARIAQVLHDGLLPLVDGTRERWFTAAFAQTHASQVEDILQRFLATSVAGYAGCCNAVGMADFRDVLGRIGVPLLAIAGDDDPVCVPAELQAIADGVAVGHFATVPGRHICNLESPQAFTAALVAHLSAQH
>NZ_CP018756.1|WP_079221603.1|1447308_1447770_-|cytochrome-c
MSKAAHTMRHAIALSVALLLAACSQSQVESSEKSAGDPGHASGEHGSSSSAGLPPGREAAGEARAKVKGKATNQSCIDCHGADGNAPIDPTYPKLGGQYGDYLAHALQAYRAGDRQHALMTPQAKDLSDQDIADLAAYFGSRPSQLRDLHGVK
>NZ_CP018756.1|WP_079221604.1|1447779_1448169_-|c-type-cytochrome
MRPQPLAACLALAVLLPLGAAAQPAPAPAAPAPAPAQASPPAAAAPAGNFDNGRVLAYTCQGCHGITGYKNAYPSYRVPKIGGQTQQYLTQALTEYRQGKRRHPTMQAQSMSFSEQEIADLAVYLSTVK
>NZ_CP018756.1|WP_079221605.1|1448375_1449533_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MSHPTFLPGRRTGLCAAALLISTSLLLGGCAAGPNSEAKAAETKDEKKVDAVPVEVAVASHRAVAASYTGTAALEPRAESQVVAKTSGVALAVLVEEGQRVTAGQPLVRLDPDRARLAVAQSEAQMRKLENNYQRAQKLVGQQMVSASDVDQLRYDLENMRAQYRLATLELSYTTVVAPISGVIASRSIKTGNFVQINTPIFRIVDNSQLEATLNVPERELATLRAGQPVVLSADALPGKTFTGTVDRIAPVVDSGSGTFRVVSAFNGTEHALQPGMFGRIRIDYDQRADALVVPRLAILDDGEPAVFRVREGKVARVPVKLGYAEGPWVEIREGLAAGDRIVTAGKVALRDGTAVQVIADPKAPKAKPATVAAGKSADKAGSQQ
>NZ_CP018756.1|WP_079221606.1|1449529_1453054_+|efflux-RND-transporter-permease-subunit
MSAPGHDHGASPGGDGAAAGLRGGLVEFATRRRVTIAMCTVTLLLFGLIALGNLKVNLLPDLSYPTLTVRTEYTGAAPTEIESLITQPVEEAVGVVKNLRKLKSVSRTGQSDVVLEFAWGTNMDQASLEVRDKMEALNLPLEAKAPVLLRFNPSTEPIMRLVLSTKAAPTSDEDAIRELTGLRRYADEDLKKKLEPVTGVAAVKVGGGLEDEIQVDIDQQKLAQLNLPIDTVIKRLKEENINISGGRLEEGSQRFLVRTVNQFADLEEIRNLLVTTQSSNGSAADSALQQMFNIAASTGSAAAVAAASAAQSASSGGGSSVVANGVPVRLKDVATVRQGYKEREAIIRLGGKESVEVAIYKEGDANTVATAEALRKRLEQIKATFPGDAELTTIEDQSRFIEHAISDVKKDAVIGGLLAILIIFLFLRDGWSTFVISLSLPVSIIATFFFMGQLGLSLNVMSLGGLALATGLVVDDSIVVLESIAKARERGLGILQAAIVGTREVSMAVVASTLTTIAVFLPLVFVDGIAGQLFRDQALTVAIAIAISLLVSMTLIPMLSSLKGRPPLAFPEEAAAEPWHPQSRWQKPVALGRRGFVASVRWSFFALAWLVVRLWRGVVAVVGPVMRKASDIAMKPYAGAERGYLRLLPNALAHPGKVLGLAALAFVGTMALVPMLGADLIPQLAQDRFEMTVKLPAGTPLKQTDALVRELQLAHGQGEGVASLYGVSGSGTRLDASPTESGENIGKLTVVMEGGGNARTEAEITERLRDTMGQHPGAQVDFARPALFSFSTPLEIELRGQDMATLEQAGQRLAALLRSNAHYADVKSTVEEGFPEIQIRFDQERAGALGLTTRQIADVVVKKVRGDVATRYSFRDRKIDVLVRAQEGDRASVDSIRRLIVNPGSSRPVTLDAVADVVATTGPSEIHRADQTRVAVVSANLRDIDLGAAMREVQQMVAEQPLGAGVGLHIGGQGEELAQAAKSLIFAFGLAIFLVYLVMASQFESLLHPFVILFTIPLALVGAILALLMTGKPISVVVFIGLILLVGLVTKNAIILIDKVNQLREAGVAKHEALVEGARSRLRPIIMTTLCTLFGFLPLAVAMGEGAEVRAPMAITVIGGLLVSTLLTLLVIPVVYDLMDRRGDAYYRERGRKHAGEGLHAAEAGPSGGAEEPA
>NZ_CP018756.1|WP_079221607.1|1453050_1456125_+|efflux-RND-transporter-permease-subunit
MSVAEFSIRRPVTTIMCFVSLVVVGLIASFRLPLEALPDISAPFLFVQIPYTGSTPEEVERTIIRPVEESLATMTGIKRMRSQATSEAASIFIEFSDWDRDIAIAASDARERIDAIRSDLPDDLQRYNVFKWSSSDQPVLKVRLASATDLTAAYDMLDREFKRRIERIPGVARVDITGAPPNEVEIAIDPDRLSAHGLSINELSDRLRTLNFSISAGQINDNGQRVRVQPVGEITDLQEMRDLVINAKGLRLGDIAEVRLKPARMNYGRRLDGNPAIGLDIFKERSANLVDVSRAALAEVEAIRAQDSMRDVQIKVIDNQGKAVTSSLLELAEAGAVGLILSVTVLFFFLRHWPSTLMVTLAIPICFTITLGFMYFAGVTLNILTMMGLLLAVGMLVDNAVVVVESIYQERERMPGQPRLASIIGTRNVAIALSAGTLCHCIVFVPNLFGETNNISIFMAQIAITISVSLLASWLVAVSLIPMLSARMATPKLLHSQTGVIARLQRHYARLLDWSLRHRGWSLLGIVLVVLVSLVPMKLTKVDMFGGGGGKDVFIGYMWKGAYTYRQMSEEVGRVEAWVEQNRERLHVQQVYSWYSEQEGGSTTVTIDEKYAKDIKALQEEIRKGLPKSARADYFIGNQGGDGGGNQGVQVQLVGDSSSMLQEIGQEVLPLLAQRPELRDVRIDNGEKGGELKVHVDRERAAAFGFNAEQVASFVGLALRGAPLREFRRGDNEVPVWVRFAGAEQSSPEDLASYSVRTGDGRSVPLLSLVSVDVGSSATQIGRTNRQTTLTIKANLAEKITAPDGRKAIEAVLKPMSFPAGYGFTFDGGDYGNDNEAMQQMVFNLLIALVMIYVVMAAVFESLLFPAAIMSGVLFSIFGVFWLFWVTGTSFGIMSFIGILVLMGVVVNNGIVMIEHINNLRRGGMGRTQALVEGSRERLRPIMMTMGTAILAMVPISLTNTQMFGDGPEYAPMARAIAGGLAFSTVVSLLFLPTIYAVLDDLRSAVTRLIRRARGLDKAAATAA
>NZ_CP018756.1|WP_079221608.1|1456408_1457641_-|TraB/GumN-family-protein
MNESMTETLPETGDDLFAGQPVRVVERDGVRYTLLGTAHVSHASVEAVEKAIDSGRFDAVAVELDPQRLQALSDPDTLAKLDLVEVIRKGRVALFAANLALSAYQRRLAEQLGIEPGAELKRAVDLARERGLPVHLIDREVGLTFRRASQRLGFFGKLKLVAGLGAGLFSSEEVGENEIEKLKQGDMLESSFGEFATESPALYETIIGERDRYMATRLREEHNPQLREVLAVVGAGHLAGLARYLETDTAEPAPLRAELEAVPKKRNIPWLTLIILAIVITGVAVGFYRGGLGVGTELLATWAMYTGGLAGIGCLLAGSHPLSILTAIAVAPFKPFRLSIPTGAFSALVEARLRKPAYEDFLKLRDDAQSLKGWYRNRVTRVVLTFMLTNLGSMLGLWLTAGKVWGKVAG
>NZ_CP018756.1|WP_079221609.1|1457633_1458164_-|N-acetyltransferase
MAVLIRDAGPADIAAITAIYAVEVTDFVNTYEYDIPDQDEMLRRMRDIIDRGFPYLVAEIDGQVAGYAYANTYRTRVAYQWTVENSVYVDAAYQGKGVGTGLLQALIDACVARGYRQMVAVIGEPTNTASIKLHERFGFHLVGVFKGLGRKHGRWLDTVQMQRALGDGADTAPSNE
>NZ_CP018756.1|WP_079221610.1|1458178_1459066_-|carbon-nitrogen-hydrolase
MNSRSPLTVALIQERNHGDAAANLAVIEARVAEAAAQGAKLVLLQELHNGPYFCQHESVDEFDLAEPIPGPSTERLGALAKKHGVVLVGSLFERRAAGLYHNTAVVFEKDGTLLGKYRKMHIPDDPGFYEKFYFTPGDIGFTPIDTSVGRLGVLVCWDQWYPEAARLMALAGAELLLYPTAIGWDPDDVQDEKTRQRDAWVLSHRGHAVANGLPVLSCNRVGHEASPLGASGIQFWGNSHVLGPQGEFLAEAGTDATVLVCDVDLQRSEHVRRIWPFLRDRRIDAYGDLLKRYID
>NZ_CP018756.1|WP_079221611.1|1459226_1460264_-|agmatine-deiminase-family-protein
MNQTLRFPAEWEAQSGVLIAWPTADTDWADRLGQVEETYIALVAAITRFQPVLICVADDDVETYAEMRLRSNRIDMDRVRFTTAAYDDTWLRDSGPITLRRADGSFQLLDFRFTGWGGKFDATLDDQLVGALDQAGVFNDAPVRSIPFALEGGGIETDGEGTLLTTWKCLHERHPDRDRASLSADLGDWLQQDRVLWLDHGYLEGDDTDAHIDTLARFASPDSIVYQACDDESDSHYDELQAMGNELAALRTKDGQPYRLFPLPWAQPVMDEGRRLAASYANYLIVNGAVLMPAYGDPADDLARDVLAQAHPGREIVQVPCRSLIWQNGSLHCITMQLPAGLLKA
>NZ_CP018756.1|WP_079221612.1|1460303_1460633_-|hypothetical-protein
MKRYLSTLAVLATLAAATPALADTLLVDRANEKPAGALPVRGQSMQQVQSQFGAPSEQLQPRGGQKRQWPTINRWVYPQFTVYFEKQKVIDVVANKADPNEIGPKPPIR

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Crispr_ID: NZ_CP018756_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_7

1456154-1456241

Unclear

Consensus_repeat	Method
ACAACGTGTTGTGGTGGGGGGAGA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP018756_7

>merge|NZ_CP018756|7|1456154-1456241|CRISPRCasFinder
ACAACGTGTTGTGGTGGGGGGAGAGACCCTGTAGAGCCGAGCCATGCTCGGCTGTAAAACGCAACAACGTGTTTGTGGTGGGGGGAGA

>NZ_CP018756|7|7|1456154-1456241|CRISPRCasFinder
ACAACGTGTTGTGGTGGGGGGAGA	GACCCTGTAGAGCCGAGCCATGCTCGGCTGTAAAACGCAA
CAACGTGTTTGTGGTGGGGGGAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221609.1\|1457633_1458164_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP018756.1\|WP_079221601.1\|1444202_1445081_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182768
NZ_CP018756.1\|WP_079221605.1\|1448375_1449533_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP018756.1\|WP_079221606.1\|1449529_1453054_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079221599.1\|1442685_1442958_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221612.1\|1460303_1460633_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221602.1\|1445269_1447153_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236861
NZ_CP018756.1\|WP_079221598.1\|1441151_1442528_-\|ATP-dependent-RNA-helicase-DbpA	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236977
NZ_CP018756.1\|WP_079221600.1\|1443020_1444100_-\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP018756.1\|WP_079221603.1\|1447308_1447770_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP018756.1\|WP_079221613.1\|1461105_1461783_+\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|234579
NZ_CP018756.1\|WP_079221608.1\|1456408_1457641_-\|TraB/GumN-family-protein	unknown	unknown	gnl\|CDD\|224828
NZ_CP018756.1\|WP_012510790.1\|1461995_1463681_+\|30S-ribosomal-protein-S1	unknown	unknown	gnl\|CDD\|235775
NZ_CP018756.1\|WP_079221604.1\|1447779_1448169_-\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|225418
NZ_CP018756.1\|WP_054656844.1\|1460782_1460908_-\|50S-ribosomal-protein-L36	unknown	unknown	gnl\|CDD\|179138
NZ_CP018756.1\|WP_079221607.1\|1453050_1456125_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_005409286.1\|1463771_1464077_+\|integration-host-factor-subunit-beta	unknown	unknown	gnl\|CDD\|178925
NZ_CP018756.1\|WP_079221611.1\|1459226_1460264_-\|agmatine-deiminase-family-protein	unknown	unknown	gnl\|CDD\|377332
NZ_CP018756.1\|WP_053511270.1\|1464154_1464439_+\|LapA-family-protein	unknown	unknown	gnl\|CDD\|377648
NZ_CP018756.1\|WP_079221610.1\|1458178_1459066_-\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143597

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221609.1\|1457633_1458164_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	3.06076e-58
NZ_CP018756.1\|WP_079221601.1\|1444202_1445081_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182768	PRK10837, PRK10837, putative DNA-binding transcriptional regulator; Provisional.	1.05132e-93
NZ_CP018756.1\|WP_079221605.1\|1448375_1449533_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.34255e-92
NZ_CP018756.1\|WP_079221606.1\|1449529_1453054_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_054656844.1\|1460782_1460908_-\|50S-ribosomal-protein-L36	gnl\|CDD\|179138	PRK00831, rpmJ, 50S ribosomal protein L36; Validated.	1.31466e-12
NZ_CP018756.1\|WP_079221602.1\|1445269_1447153_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NZ_CP018756.1\|WP_079221598.1\|1441151_1442528_-\|ATP-dependent-RNA-helicase-DbpA	gnl\|CDD\|236977	PRK11776, PRK11776, ATP-dependent RNA helicase DbpA; Provisional.	0
NZ_CP018756.1\|WP_079221600.1\|1443020_1444100_-\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	6.93414e-103
NZ_CP018756.1\|WP_079221603.1\|1447308_1447770_-\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	1.27766e-19
NZ_CP018756.1\|WP_079221613.1\|1461105_1461783_+\|(d)CMP-kinase	gnl\|CDD\|234579	PRK00023, cmk, (d)CMP kinase.	1.10983e-114
NZ_CP018756.1\|WP_079221608.1\|1456408_1457641_-\|TraB/GumN-family-protein	gnl\|CDD\|224828	COG1916, COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown].	5.20671e-137
NZ_CP018756.1\|WP_012510790.1\|1461995_1463681_+\|30S-ribosomal-protein-S1	gnl\|CDD\|235775	PRK06299, rpsA, 30S ribosomal protein S1; Reviewed.	0
NZ_CP018756.1\|WP_079221604.1\|1447779_1448169_-\|c-type-cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	3.16325e-14
NZ_CP018756.1\|WP_079221607.1\|1453050_1456125_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_005409286.1\|1463771_1464077_+\|integration-host-factor-subunit-beta	gnl\|CDD\|178925	PRK00199, ihfB, integration host factor subunit beta; Reviewed.	4.39825e-61
NZ_CP018756.1\|WP_079221611.1\|1459226_1460264_-\|agmatine-deiminase-family-protein	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	2.7198e-150
NZ_CP018756.1\|WP_053511270.1\|1464154_1464439_+\|LapA-family-protein	gnl\|CDD\|377648	pfam06305, LapA_dom, Lipopolysaccharide assembly protein A domain. This family includes a domain found in lipopolysaccharide assembly protein A (LapA). LapA functions along with LapB in the assembly of lipopolysaccharide (LPS). Domains in this family are also found in some uncharacterized bacterial proteins.	1.9778e-05
NZ_CP018756.1\|WP_079221610.1\|1458178_1459066_-\|carbon-nitrogen-hydrolase	gnl\|CDD\|143597	cd07573, CPA, N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53, also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine, a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA, also known as nitrilase-like 1 (NLP1), and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer; P. aeruginosa AugB is a homohexamer, Arabidopsis thaliana NLP1 is a homooctomer.	4.25987e-177

>NZ_CP018756.1|WP_079221607.1|1453050_1456125_+|efflux-RND-transporter-permease-subunit
MSVAEFSIRRPVTTIMCFVSLVVVGLIASFRLPLEALPDISAPFLFVQIPYTGSTPEEVERTIIRPVEESLATMTGIKRMRSQATSEAASIFIEFSDWDRDIAIAASDARERIDAIRSDLPDDLQRYNVFKWSSSDQPVLKVRLASATDLTAAYDMLDREFKRRIERIPGVARVDITGAPPNEVEIAIDPDRLSAHGLSINELSDRLRTLNFSISAGQINDNGQRVRVQPVGEITDLQEMRDLVINAKGLRLGDIAEVRLKPARMNYGRRLDGNPAIGLDIFKERSANLVDVSRAALAEVEAIRAQDSMRDVQIKVIDNQGKAVTSSLLELAEAGAVGLILSVTVLFFFLRHWPSTLMVTLAIPICFTITLGFMYFAGVTLNILTMMGLLLAVGMLVDNAVVVVESIYQERERMPGQPRLASIIGTRNVAIALSAGTLCHCIVFVPNLFGETNNISIFMAQIAITISVSLLASWLVAVSLIPMLSARMATPKLLHSQTGVIARLQRHYARLLDWSLRHRGWSLLGIVLVVLVSLVPMKLTKVDMFGGGGGKDVFIGYMWKGAYTYRQMSEEVGRVEAWVEQNRERLHVQQVYSWYSEQEGGSTTVTIDEKYAKDIKALQEEIRKGLPKSARADYFIGNQGGDGGGNQGVQVQLVGDSSSMLQEIGQEVLPLLAQRPELRDVRIDNGEKGGELKVHVDRERAAAFGFNAEQVASFVGLALRGAPLREFRRGDNEVPVWVRFAGAEQSSPEDLASYSVRTGDGRSVPLLSLVSVDVGSSATQIGRTNRQTTLTIKANLAEKITAPDGRKAIEAVLKPMSFPAGYGFTFDGGDYGNDNEAMQQMVFNLLIALVMIYVVMAAVFESLLFPAAIMSGVLFSIFGVFWLFWVTGTSFGIMSFIGILVLMGVVVNNGIVMIEHINNLRRGGMGRTQALVEGSRERLRPIMMTMGTAILAMVPISLTNTQMFGDGPEYAPMARAIAGGLAFSTVVSLLFLPTIYAVLDDLRSAVTRLIRRARGLDKAAATAA
>NZ_CP018756.1|WP_079221606.1|1449529_1453054_+|efflux-RND-transporter-permease-subunit
MSAPGHDHGASPGGDGAAAGLRGGLVEFATRRRVTIAMCTVTLLLFGLIALGNLKVNLLPDLSYPTLTVRTEYTGAAPTEIESLITQPVEEAVGVVKNLRKLKSVSRTGQSDVVLEFAWGTNMDQASLEVRDKMEALNLPLEAKAPVLLRFNPSTEPIMRLVLSTKAAPTSDEDAIRELTGLRRYADEDLKKKLEPVTGVAAVKVGGGLEDEIQVDIDQQKLAQLNLPIDTVIKRLKEENINISGGRLEEGSQRFLVRTVNQFADLEEIRNLLVTTQSSNGSAADSALQQMFNIAASTGSAAAVAAASAAQSASSGGGSSVVANGVPVRLKDVATVRQGYKEREAIIRLGGKESVEVAIYKEGDANTVATAEALRKRLEQIKATFPGDAELTTIEDQSRFIEHAISDVKKDAVIGGLLAILIIFLFLRDGWSTFVISLSLPVSIIATFFFMGQLGLSLNVMSLGGLALATGLVVDDSIVVLESIAKARERGLGILQAAIVGTREVSMAVVASTLTTIAVFLPLVFVDGIAGQLFRDQALTVAIAIAISLLVSMTLIPMLSSLKGRPPLAFPEEAAAEPWHPQSRWQKPVALGRRGFVASVRWSFFALAWLVVRLWRGVVAVVGPVMRKASDIAMKPYAGAERGYLRLLPNALAHPGKVLGLAALAFVGTMALVPMLGADLIPQLAQDRFEMTVKLPAGTPLKQTDALVRELQLAHGQGEGVASLYGVSGSGTRLDASPTESGENIGKLTVVMEGGGNARTEAEITERLRDTMGQHPGAQVDFARPALFSFSTPLEIELRGQDMATLEQAGQRLAALLRSNAHYADVKSTVEEGFPEIQIRFDQERAGALGLTTRQIADVVVKKVRGDVATRYSFRDRKIDVLVRAQEGDRASVDSIRRLIVNPGSSRPVTLDAVADVVATTGPSEIHRADQTRVAVVSANLRDIDLGAAMREVQQMVAEQPLGAGVGLHIGGQGEELAQAAKSLIFAFGLAIFLVYLVMASQFESLLHPFVILFTIPLALVGAILALLMTGKPISVVVFIGLILLVGLVTKNAIILIDKVNQLREAGVAKHEALVEGARSRLRPIIMTTLCTLFGFLPLAVAMGEGAEVRAPMAITVIGGLLVSTLLTLLVIPVVYDLMDRRGDAYYRERGRKHAGEGLHAAEAGPSGGAEEPA
>NZ_CP018756.1|WP_079221605.1|1448375_1449533_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MSHPTFLPGRRTGLCAAALLISTSLLLGGCAAGPNSEAKAAETKDEKKVDAVPVEVAVASHRAVAASYTGTAALEPRAESQVVAKTSGVALAVLVEEGQRVTAGQPLVRLDPDRARLAVAQSEAQMRKLENNYQRAQKLVGQQMVSASDVDQLRYDLENMRAQYRLATLELSYTTVVAPISGVIASRSIKTGNFVQINTPIFRIVDNSQLEATLNVPERELATLRAGQPVVLSADALPGKTFTGTVDRIAPVVDSGSGTFRVVSAFNGTEHALQPGMFGRIRIDYDQRADALVVPRLAILDDGEPAVFRVREGKVARVPVKLGYAEGPWVEIREGLAAGDRIVTAGKVALRDGTAVQVIADPKAPKAKPATVAAGKSADKAGSQQ
>NZ_CP018756.1|WP_079221604.1|1447779_1448169_-|c-type-cytochrome
MRPQPLAACLALAVLLPLGAAAQPAPAPAAPAPAPAQASPPAAAAPAGNFDNGRVLAYTCQGCHGITGYKNAYPSYRVPKIGGQTQQYLTQALTEYRQGKRRHPTMQAQSMSFSEQEIADLAVYLSTVK
>NZ_CP018756.1|WP_079221603.1|1447308_1447770_-|cytochrome-c
MSKAAHTMRHAIALSVALLLAACSQSQVESSEKSAGDPGHASGEHGSSSSAGLPPGREAAGEARAKVKGKATNQSCIDCHGADGNAPIDPTYPKLGGQYGDYLAHALQAYRAGDRQHALMTPQAKDLSDQDIADLAAYFGSRPSQLRDLHGVK
>NZ_CP018756.1|WP_079221602.1|1445269_1447153_+|ATP-binding-cassette-domain-containing-protein
MPLITLQNVDFSVGGPLLLEKAELSIEPGERIALIGRNGAGKSTLLKLLSGDHKPDDGEVRVQQGVRVTRLEQEVPHGAAGSVFDVVADGLGELGQWLAEFHHLSHAEVFDGEALGNVQAKIDAANGWGLDQRVSETLTKLDLDGEAEFGRLSGGMKRRVLLARALVSSPDVLLLDEPTNHLDIEAIDWLEAFLKGWSGSVVFVTHDRRFLRALATRIVEIDRGQVTSWPGDWANYERRREERLNAQAQENARFDKLLAQEEVWIRQGIKARRTRDEGRVRRLKAMRNERSQRRDLSGNVKMEAAQGVSSGKKVIDVKDVSFAFGERTMVRDFTTTILRGDRIGLIGPNGSGKTTLLKLLLGELQPAKGEVNAGTNLQIAYFDQYRAVLREDWSAIENVAEGRDFLEFNGKRKHVHAYLQDFMFTPERARAPITRLSGGERNRLLLAKLFAQPSNLLVMDEPTNDLDVETLELLEELLGEYTGTLLLVSHDRDFIDNVVTSTLVMEGDGVIGEYVGGYTDWQRYAASVATPAAAPATKPAAAAPAVAAAAAPAAPKRKLAYKEARELEQLPKTIEKLEGDVEGLTAAMNDPSFYTRSSAEVTAHTQQLAKVQAELDAAYARWEELEG
>NZ_CP018756.1|WP_079221601.1|1444202_1445081_+|LysR-family-transcriptional-regulator
MRLTLRQLQVFVAIADHGSTTAAGQAIALSQSASSAALQELEAHFGTPLFDRIGRRLALNGHGRALLEPARALLVNAADLERQLAAGGDPGQGAPLRLVLAASTTIGNYLLPPRIAALLRQAPQAEVDLRIDNSAGVVAAVQRLDVDAGLIEGPCHERGLQVTPWQQDPLVIVAAPDAPARWSLDELRGARWLLREPGSGTREAVEQALLPHLHGFAQTLQLGNTEAIKQAAIAGLGVACLSRHALEEPLALGRLRVLETPLPLLQRTLWLVRHPGKQWLPGLQALLGEAQR
>NZ_CP018756.1|WP_079221600.1|1443020_1444100_-|YeiH-family-putative-sulfate-export-transporter
MNASTLSPWSLPALRQRWQPRLPGLLLVGLVAAASLSLAELPWLQAHGLSALTVAIVAGIVVGNTFYPRLAPGSAAGVGFSKHWLLRAGIVLYGLRLTFQDIGHVGVAGVAMDALVVASTFGLACWLGVRVFRMDREAAMLIGAGSAICGAAAVMAAEPVVRGRAAQVTVAVSTVVVFGTLAMFLYPALYALVQSHGLLAMDARQYGLFTGATMHEVAQVVAAGRAVSESAADTAVITKMVRVMLLAPFLVVLSLWLARGGKAAADGSTPRIVVPWFAFGFVAVAGFNSLHLLPAGVQAGLVQLDTVLLAMAMAALGLTTHVSALRQAGLKPLLLASILFAWLLLGGLAIHQGVLAVLG
>NZ_CP018756.1|WP_079221599.1|1442685_1442958_-|hypothetical-protein
MTASPALLPIPLRLLDDRYGPGNADEAEDTLIGIVQAVMGVRATCSFDFDTRHANPWFHQLLLGPQADGHPATPAQLQAMAVRLAAIGLG
>NZ_CP018756.1|WP_079221598.1|1441151_1442528_-|ATP-dependent-RNA-helicase-DbpA
MTDFSTLPLSPALQPGLDALGYTTLTPIQAQSLPAILDRCDVIAQAPTGSGKTAAFGLGLLQAIDPSLIRVQALVLCPTRELADQVAKQIRKLATGIPNLKLLLLVGGVPLGPQLASLEGHDPHVVVGTPGRVQELARKRALNLGAVRTLVLDEADRMLDMGFEEPIREIAGRTHKDRQTLLFSATFPDSIREIARDLLRDALEVTVEGADQAPAIRHLFCEVEPAHRQKALAGLLLKYTPESAVVFCNTRKDVDEVANSLQQFGFSALALHGDMEQRDREEVLLRLANRSCNVLVASDVAARGLDVEELAAVINYELPTDVESYQHRVGRTGRAGASGLAISLVAGREKTRAEAVEAHLGQPLDWQKTPLATSRPAELPQAAMRTLRIDGGKTDKLRPGDILGALTGDAGLSGKHIGKIAIFPTRSYVAIAREQVNKAVAKLEAGKIKGRRFRVRMM
>NZ_CP018756.1|WP_079221608.1|1456408_1457641_-|TraB/GumN-family-protein
MNESMTETLPETGDDLFAGQPVRVVERDGVRYTLLGTAHVSHASVEAVEKAIDSGRFDAVAVELDPQRLQALSDPDTLAKLDLVEVIRKGRVALFAANLALSAYQRRLAEQLGIEPGAELKRAVDLARERGLPVHLIDREVGLTFRRASQRLGFFGKLKLVAGLGAGLFSSEEVGENEIEKLKQGDMLESSFGEFATESPALYETIIGERDRYMATRLREEHNPQLREVLAVVGAGHLAGLARYLETDTAEPAPLRAELEAVPKKRNIPWLTLIILAIVITGVAVGFYRGGLGVGTELLATWAMYTGGLAGIGCLLAGSHPLSILTAIAVAPFKPFRLSIPTGAFSALVEARLRKPAYEDFLKLRDDAQSLKGWYRNRVTRVVLTFMLTNLGSMLGLWLTAGKVWGKVAG
>NZ_CP018756.1|WP_079221609.1|1457633_1458164_-|N-acetyltransferase
MAVLIRDAGPADIAAITAIYAVEVTDFVNTYEYDIPDQDEMLRRMRDIIDRGFPYLVAEIDGQVAGYAYANTYRTRVAYQWTVENSVYVDAAYQGKGVGTGLLQALIDACVARGYRQMVAVIGEPTNTASIKLHERFGFHLVGVFKGLGRKHGRWLDTVQMQRALGDGADTAPSNE
>NZ_CP018756.1|WP_079221610.1|1458178_1459066_-|carbon-nitrogen-hydrolase
MNSRSPLTVALIQERNHGDAAANLAVIEARVAEAAAQGAKLVLLQELHNGPYFCQHESVDEFDLAEPIPGPSTERLGALAKKHGVVLVGSLFERRAAGLYHNTAVVFEKDGTLLGKYRKMHIPDDPGFYEKFYFTPGDIGFTPIDTSVGRLGVLVCWDQWYPEAARLMALAGAELLLYPTAIGWDPDDVQDEKTRQRDAWVLSHRGHAVANGLPVLSCNRVGHEASPLGASGIQFWGNSHVLGPQGEFLAEAGTDATVLVCDVDLQRSEHVRRIWPFLRDRRIDAYGDLLKRYID
>NZ_CP018756.1|WP_079221611.1|1459226_1460264_-|agmatine-deiminase-family-protein
MNQTLRFPAEWEAQSGVLIAWPTADTDWADRLGQVEETYIALVAAITRFQPVLICVADDDVETYAEMRLRSNRIDMDRVRFTTAAYDDTWLRDSGPITLRRADGSFQLLDFRFTGWGGKFDATLDDQLVGALDQAGVFNDAPVRSIPFALEGGGIETDGEGTLLTTWKCLHERHPDRDRASLSADLGDWLQQDRVLWLDHGYLEGDDTDAHIDTLARFASPDSIVYQACDDESDSHYDELQAMGNELAALRTKDGQPYRLFPLPWAQPVMDEGRRLAASYANYLIVNGAVLMPAYGDPADDLARDVLAQAHPGREIVQVPCRSLIWQNGSLHCITMQLPAGLLKA
>NZ_CP018756.1|WP_079221612.1|1460303_1460633_-|hypothetical-protein
MKRYLSTLAVLATLAAATPALADTLLVDRANEKPAGALPVRGQSMQQVQSQFGAPSEQLQPRGGQKRQWPTINRWVYPQFTVYFEKQKVIDVVANKADPNEIGPKPPIR
>NZ_CP018756.1|WP_054656844.1|1460782_1460908_-|50S-ribosomal-protein-L36
MKILSSLKSAKARHRDCKVVRRRGKIFVICKSNPRFKARQR
>NZ_CP018756.1|WP_079221613.1|1461105_1461783_+|(d)CMP-kinase
MNPLAPVLTIDGPSGAGKGTISRIVARRLGWHYLDSGALYRAVGVAASWADIDTSDASALVRCTFDTHVQFVEQGESMRVMVNGTDATDELRLETTGALASAIAAIPEVRAALKERQRAFRELPGLVADGRDMGTVIFKDAPYKVFLTASAEERAERRHKQLKDKGVSVNFDDLLREIMARDARDAQRTVAPLKPADDAVLIDTTGIGIDDVVARVMDLLPVPAA
>NZ_CP018756.1|WP_012510790.1|1461995_1463681_+|30S-ribosomal-protein-S1
MTESFAELFEASQANLAKLKPGAIVSGTVVEVRGDVVVINAGLKSEGIVPIEQFRNDAGEIDVAEGDIVKVALDSIENGFGETVLSREKAKRAMVWDELEEALEKNETITGRISGKVKGGFTVDIKDVRAFLPGSLVDVRPVRDPAYLEGKELEFKLIKLDRKRNNVVVSRRAVVESEHSEEREQLMDKLQEGAILKGVVKNLTDYGAFVDLGGIDGLLHITDMAWKRVRHPSEVVNVGDELDVRVLKFDRERNRVSLGLKQLGEDPWDNIARRYPANSRVFGKVSNVTDYGAFVEIEPGVEGLVHVSEMDWTNKNVNPSKVVQVGDEVEVMVLDVDEERRRISLGMKQVAANPWETFAATHKKGDKVSGQIKSITDFGIFIGLDGGIDGLVHLSDISWATTGEDIVRNFKKGDTLDAVVLAVDPERERISLGVKQLEQDPFGQYMAANPKGSKVEGVVKEVDAKGAIIELADGIEGYVSARDIANERVDDATQHLKVGDKVEAKFVGMDRKGRTLQLSIKAKDDAEMREVLEEYQSSSAASGTTQLGALLRAQLSGNKSE
>NZ_CP018756.1|WP_005409286.1|1463771_1464077_+|integration-host-factor-subunit-beta
MTKSELIEILARRQAHLKADDVDLAVKSLLEMMGGSLSAGDRIEIRGFGSFSLHYRPPRLGRNPKTGESVALPGKHVPHFKPGKELRERVSSVLPLDADPA
>NZ_CP018756.1|WP_053511270.1|1464154_1464439_+|LapA-family-protein
MKVFRLLVLLAVLLLGLIIGAMNMDEMTINLVFTQLKTSIGVAIIASLLIGVIVGAGLVLVSVVIPLYAQLRRANKSVATPVAPVSPSQSFDGR

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Crispr_ID: NZ_CP018756_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_8

1485634-1485711

Orphan

Consensus_repeat	Method
GACCAACGGTCCGCACCTACCAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_8

>merge|NZ_CP018756|8|1485634-1485711|CRISPRCasFinder
GACCAACGGTCCGCACCTACCAAAAACAGGCCGGGCTGGCTCCTGGTGGGTGCCGACCAACGGTCCGCACCCACCAAA

>NZ_CP018756|8|8|1485634-1485711|CRISPRCasFinder
GACCAACGGTCCGCACCTACCAAA	AACAGGCCGGGCTGGCTCCTGGTGGGTGCC
GACCAACGGTCCGCACCCACCAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221629.1\|1487498_1489064_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP018756.1\|WP_079221624.1\|1478607_1479816_+\|outer-membrane-protein-assembly-factor-BamB	unknown	unknown	gnl\|CDD\|274511
NZ_CP018756.1\|WP_079221623.1\|1477969_1478608_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225523
NZ_CP018756.1\|WP_152027174.1\|1489831_1493266_+\|ATP-binding-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221621.1\|1476218_1477022_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225605
NZ_CP018756.1\|WP_079221631.1\|1493720_1494623_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP018756.1\|WP_079221625.1\|1479831_1481229_+\|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl\|CDD\|234628
NZ_CP018756.1\|WP_079221627.1\|1482716_1484552_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|235131
NZ_CP018756.1\|WP_079221628.1\|1484711_1485590_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	unknown	unknown	gnl\|CDD\|236760
NZ_CP018756.1\|WP_079221635.1\|1497177_1497534_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225191.1\|1485931_1487389_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NZ_CP018756.1\|WP_079221620.1\|1475026_1476232_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|183031
NZ_CP018756.1\|WP_079221636.1\|1498195_1499272_-\|DUF4263-domain-containing-protein	unknown	unknown	gnl\|CDD\|372906
NZ_CP018756.1\|WP_079221634.1\|1496257_1497040_+\|3-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|187644
NZ_CP018756.1\|WP_008265389.1\|1474590_1475016_+\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_CP018756.1\|WP_079221633.1\|1495869_1496181_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221637.1\|1499557_1499857_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221632.1\|1494717_1495557_+\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
NZ_CP018756.1\|WP_079221622.1\|1477041_1477905_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224343
NZ_CP018756.1\|WP_079221626.1\|1481413_1482550_+\|molybdopterin-synthase-adenylyltransferase-MoeB	unknown	unknown	gnl\|CDD\|236337

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221629.1\|1487498_1489064_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP018756.1\|WP_079221624.1\|1478607_1479816_+\|outer-membrane-protein-assembly-factor-BamB	gnl\|CDD\|274511	TIGR03300, assembly_YfgL, outer membrane assembly lipoprotein YfgL. Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking].	1.28496e-147
NZ_CP018756.1\|WP_079221623.1\|1477969_1478608_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|225523	COG2976, COG2976, Uncharacterized protein conserved in bacteria [Function unknown].	1.04023e-40
NZ_CP018756.1\|WP_079221621.1\|1476218_1477022_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|225605	COG3063, PilF, Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion].	3.66376e-44
NZ_CP018756.1\|WP_079221631.1\|1493720_1494623_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.64821e-69
NZ_CP018756.1\|WP_079221625.1\|1479831_1481229_+\|ribosome-biogenesis-GTPase-Der	gnl\|CDD\|234628	PRK00093, PRK00093, GTP-binding protein Der; Reviewed.	0
NZ_CP018756.1\|WP_079221627.1\|1482716_1484552_+\|cation:proton-antiporter	gnl\|CDD\|235131	PRK03562, PRK03562, glutathione-regulated potassium-efflux system protein KefC; Provisional.	0
NZ_CP018756.1\|WP_079221628.1\|1484711_1485590_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	gnl\|CDD\|236760	PRK10792, PRK10792, bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD.	0
NZ_CP018756.1\|WP_079225191.1\|1485931_1487389_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NZ_CP018756.1\|WP_079221620.1\|1475026_1476232_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|183031	PRK11194, PRK11194, ribosomal RNA large subunit methyltransferase N; Provisional.	1.10978e-177
NZ_CP018756.1\|WP_079221636.1\|1498195_1499272_-\|DUF4263-domain-containing-protein	gnl\|CDD\|372906	pfam14082, DUF4263, Domain of unknown function (DUF4263). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 244 and 403 amino acids in length.	1.01014e-18
NZ_CP018756.1\|WP_079221634.1\|1496257_1497040_+\|3-hydroxybutyrate-dehydrogenase	gnl\|CDD\|187644	cd08940, HBDH_SDR_c, d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs. DHBDH, an NAD+ -dependent enzyme, catalyzes the interconversion of D-3-hydroxybutyrate and acetoacetate. It is a classical SDR, with the canonical NAD-binding motif and active site tetrad. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	9.57613e-153
NZ_CP018756.1\|WP_008265389.1\|1474590_1475016_+\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	2.07613e-86
NZ_CP018756.1\|WP_079221632.1\|1494717_1495557_+\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	2.11311e-73
NZ_CP018756.1\|WP_079221622.1\|1477041_1477905_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224343	COG1426, COG1426, Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown].	2.11437e-28
NZ_CP018756.1\|WP_079221626.1\|1481413_1482550_+\|molybdopterin-synthase-adenylyltransferase-MoeB	gnl\|CDD\|236337	PRK08762, PRK08762, molybdopterin-synthase adenylyltransferase MoeB.	0

>NZ_CP018756.1|WP_079221628.1|1484711_1485590_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD
MTDSAPQLPARILDGRRIAEDLLDSLKVRVDARVAAGGSRPGLAVVLVGGDPASTVYVRNKRRAAEKVGIEAHDYDLPAGTSEAELLDLIDQLNADPKINGILIQLPLPGIPDARRLIQRIDPRKDVDGFHPENVGHLALREFGLRPCTPRGITTLLGHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPKDVLEQAVRNADILVVAVGRPGIVPGEWVKPGAVVIDVGINRLDDGRLVGDVGFEAAAERASWITPVPGGVGPMTVATLMQNTLEAAEALS
>NZ_CP018756.1|WP_079221627.1|1482716_1484552_+|cation:proton-antiporter
MAVEAATSELVKVVALLGAAVVMVPLFRRLGLGSVLGYFAAGLAIGPFGLGWFSDPQAILHTAELGVVMFLFVIGLEMRPSHLWSLRKEIFGLGTLQIATCALVLTTIAKLFGLPWQVAFIGATGFVLTSTAVVMQLLAERGDIALPSGQKIVSILLFEDLLIVPLLALVAWMAPSAGSADGEGSRWLSVAIGVGAIVGLVLVGRFLLNPLFRLLAESKAREVMTAAALLVVLGAALLMQLSGLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLSVGMALDLGVVAGNWPMIVGLVLALMAAKALCIYVVARLMGSDHAQAMDRGVLMAQGGEFAFVLFSAAASAGVIDMDINANFTAVVVLSMALTPLVVLVYKRVAPKPEVSLEGVDTADGLSGSVLMIGFGRFGQVASQSLLARDVDVTIIDNDVEMIHNAERFGFKIYYGDGTRLDVLHASGAGTARAIAVCVNNAEDADRIVELVAHEFPQAKLLVRSFDREHSLRLIHAGVDFQIRETFESALMFGQAALMELGADEDDAQEIAEQIRERDAERFELEMAGGSLRAGAHMVFGSALPGVPTPTPFTAPKRKARTLNADQVPEEEED
>NZ_CP018756.1|WP_079221626.1|1481413_1482550_+|molybdopterin-synthase-adenylyltransferase-MoeB
MSIPELSPEQARARVAHGAVLIDVRQAHERAGGMAEGARGVAKDDLLADPAAHLPAPGQEILLICQSGKRSADAAQALLAAGYSNVASVAGGTVAWREQALPLVQPMLDAADRDFYDRYSRHLLLPQVGEAGQRRLQQSRVLVLGAGGLGAPAGFYLAAAGVGHLRFADHDRVERSNLHRQIVHTEASVGQLKVDSARERLLALNPSIEVEAVPERVTSENVDRLLDGVDVVLDGSDNFPLRYLLNDACIKHAKPMVYAAIERFDGQVSVFDAGRQRGVAPCYRCLFPEPPPPEFAPNCSEAGVLGVLPGLAGVLQATEVLKLLLGIGEPLVGRLLRFDALGMRFRETGIGPDPACPVCAPGVLFPGYIDYTALCSGG
>NZ_CP018756.1|WP_079221625.1|1479831_1481229_+|ribosome-biogenesis-GTPase-Der
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEDNHFLVVDTGGIAEEEEGLAGATTRQARAAAAEADLILFVVDAREGTSAMDDEILAWLRKLSRPTLLLINKIDGTDEDTVRSEFARYGFGEMLTVSAAHRQGLDDLMDEVIQRLPEEGSGEELDNDPNRIRIAFVGRPNVGKSTLVNRILGEERMIASDVPGTTRDSIAVDLERDGREYRLIDTAGLRRRSRVDEVVEKFSVVKTMQSIEQCQVAVLMLDATEGVTDQDATVLGAVLDAGRALVIAINKWDGLTEYQREQAETMLSLRLGFVPWAESVRISAKHGSGLRELFRAVHRAHESANKTFTTSEVNKALEMAYETNPPPTIRGHVSKLRYVHPAGANPPTFIVHGTRLKELQESYKRYLENFFRKRFKLIGTPVSFIFREGTNPYEGKKNVLTERQVKAKRRLMKHVKGK
>NZ_CP018756.1|WP_079221624.1|1478607_1479816_+|outer-membrane-protein-assembly-factor-BamB
MSQKVMITRVASVLLLGMALTGCSTMKGWFAGKDAAAKKAQEPAELVKFEPTLKVNKAWSVNLGKGERRIGVRQGPAVANGHVFAAAITGGVHAIDLQTGKKVWTWEPQKEKKKAKLRLSGGPGVGENLVVIGTLDGQVIALDINDGSEKWRARVPGEVISAPAVSQGLVFVRSNDGRVTAFEASNGTQKWFNPSELPALTVRGNAPVVTGPGVLFIGKDDGAVAALAMQDGRTLWDQTVGSPEGRTELDRMADIDGAPVLEGNTLFVSSFKNQTMAIEGPTGRPLWARDHGGAGGVAVSSGNVFVTDPKGGVFGLDKTSGTAMWSQTGLARRSLTGPALQGDYVVVGDYKGYLHWLQASDGAMAARAKSGGDALLAQPVVVDGVLLVQNVDGKLTAFRLAN
>NZ_CP018756.1|WP_079221623.1|1477969_1478608_+|tetratricopeptide-repeat-protein
MAIDDLLDEHEQSERVRSWLRKNGASIIGGVAIAIGAIAGWQWYQTNQGGKLASANVEYQKALVGLQDNKLDDAAKAVKALEAGPNSIYGDLAALQLAKAQVDAGKNEEALATLRGVKVEGDLQRVVDQRVARLLVATGKSDEAIKLLGSATDSGSLEIQGDALLAQGKRDAAREQYEKALKTLDVAAPQRRVLETKVMDAGGTVAAPAESV
>NZ_CP018756.1|WP_079221622.1|1477041_1477905_+|helix-turn-helix-domain-containing-protein
MIDDQTVSALDTAAGCGTRLRQAREAAGLTLDDVGQRLRMPVQVVKSLEEEQWQKLGAPVFVRGQLRSYARLLNVDISQLLEQAQVGAVVPPTLVSHTHTPRARRIAENLGRRMLYVGITAVLAVPVWFATRGHFDNTPSAPNTASLDAIPAAVPVAPATVGSEPAARNEPAAVAAKPAATPYVASLAPVPRPAPAAAATANLDMQFSGDSWVDIAGPDGGSVEKALIKAGETRSFTPGQVSRVTLGNASAVQVQQNGAIVDLTPYQRANVARFQVSSEGSVVPVSH
>NZ_CP018756.1|WP_079221621.1|1476218_1477022_+|tetratricopeptide-repeat-protein
MRPRDRLWPVLIAGVLAVSASGCSKTVKSQLPDEYTRGGDIAPERHVRDSPGVREEFRYQDQLALAARDMQVGNLDEAERKVRQALKVRPKGVDAVMLMAGIDERRGRSEKAGEGFRRATELAPQRADVLNNYGAWLCQHGSAAESLLWFDRSLQLPGNASAGGAMANAGRCALDAGQVERAERDLRAALVMVPANPVALEAMAQLNFRRGQFFEARAFAERRIAAAPATRSVLQLASEIEARLGDQAASDRYLQRIRQEFPQDAGS
>NZ_CP018756.1|WP_079221620.1|1475026_1476232_+|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MNEVVQSPAIQPLPKSAPTAGKQNLLDLDRAGLEKFFVEVLGEKKFRAHQVMKWIHHRYVTDFDEMTDLGKVLRAKLQAHAEVLVPNIVFDKPSADGTHKWLLAMGVDGKNAIETVYIPDKTRGTLCVSSQVGCGLNCTFCSTATQGFNRNLTTAEIIGQVWVAARHLGNVPHQMRRLTNVVMMGMGEPLMNFDNVVRAMSVMRDDLGYGLANKRVTLSTSGLVPQIDRLSTESDVSLAVSLHAPNDALRETLVPLNKKYPIAELMASCARYLRANKRRESVTFEYTLMKGINDKPEHARELARLMRQFDNAVQAKDSGKVNLIPFNPFPGTRYERSEEAHIRAFQKILLDSNVLTMVRRTRGDDIDAACGQLKGQVMDRTRRQAEFNKTLQAGKGSDAAA
>NZ_CP018756.1|WP_008265389.1|1474590_1475016_+|nucleoside-diphosphate-kinase
MALERTLSIIKPDAVAKNVIGEIYARFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFFNALVEFMISGPVMIQALEGENAVLAHRDLLGATNPKEAAAGTIRADFAESIDANAAHGSDSVENAAIEIAYFFAATEVVSR
>NZ_CP018756.1|WP_079225191.1|1485931_1487389_+|IMP-dehydrogenase
MLRIQAEALTYDDVSLVPAHSTILPKDVNLETRLTRDLKLKLPILSAAMDTVTEARLAIAMAQLGGMGIIHKNLSLEQQAAEVAKVKKFEAGVIRDPITVGPETTIRDVLALTQAHNISGVPVVGSDGLLAGIVTHRDMRFETELDDPVRHIMTKKDRLVTVKEGAASDEVLQLLHRNRIEKVLVVNDDFALRGLITVKDIQKNTDFPNAAKDLSTRLLVGAAVGVGGDTDRRVEALVAAGVDVIVVDTAHGHSQGVLDRVAWVKKNFPNVQVIGGNICTGEAALALLDSGADAVKVGIGPGSICTTRVVAGVGVPQVTAIDLVAEALQDRIPLIADGGIRYSGDIGKALAAGASTIMVGGLLAGTEESPGETELYQGRSYKSYRGMGSLAAMEKGSKDRYFQDAATADKLVPEGIEGRVPYRGPVGGIIHQLMGGLRATMGYVGCATIDDMRTKPKFVKISGAGQRESHVHDVTITKEPPNYRA
>NZ_CP018756.1|WP_079221629.1|1487498_1489064_+|glutamine-hydrolyzing-GMP-synthase
MTNIHNDKILILDFGAQYTQLIARRIRELGVYCEIWAWDHNPAEIAAFGAKGIILSGGPESTTLPGAPAAPQEVFDSGLPIFGICYGMQTLAAQLGGATEAADQREFGHAEVNVINPDALFKGLGDHGGEPKLNVWMSHGDHVSVAPPGFTITATTDRIPVAAMANEEKRWYGVQFHPEVTHTLQGQALLRRFVVDVCGCQTLWTAANIIDDQIARVREQVGDDEVILGLSGGVDSSVVAALLHKAIGEKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVVRVNAADRYFSALEGVSDPEAKRKIIGNLFVEIFDEESNKLKNAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFPGPGLGVRILGEVKREYAELLAKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAHWAHLPYEFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE
>NZ_CP018756.1|WP_152027174.1|1489831_1493266_+|ATP-binding-protein
MSNIALTGPYGSGKSSIIKSFVKKYRRPALQISLAAFLTEDTSSKQKVSKQEIERSILQQMLYGADANQLPLSRFKRIKSPSKWSILFSFFAIVGATAFWVIYQRRGEVIDGTYFLPVSISNWANYLWFAIGASFLWVAVYRAYKASFGVSLKSVSLKDIEITPAAVSQESILNRHLDEIIYFFQSTDYDLVIIEDLDRFNDSDIFVTLREINSLVNANAGVKRPIRFLYALRDDMFISTERTKFFEFIIPVIPIINSSNSIDKVLEQGKRLSIDSRLDQRFLREVSRYLNDLRLIHNIFNEYAIYVANLELDDDNVLDATKLLAVLIYKNVFPRDFESLHRGKGNLAKILARHDEFIARAEEKNREKIDEIEGRLASADRQVPTDLLELRRIYAMALVERLPASSYRVGQNGQSMIEIGDLARSESFDQIISSRRVVVAVNNYYGSSNQNVDISGLQEDVDSQRAFGDRQKEIQRRAADFKSSAAKKLQVLRAASAKLRSSKFSEIIRINIDDLDGIFEGFGEGHELARFLILEGHVDDTYYQYTSLFHAGRMSPNDNKFLIQIRGFIVPDPSFPIDNVKEVVAGMRDEDFRQPYVLNVKVVDCLLGNSTTYKDQLAKMFDYMASNFEGCAAFFASYYVAGAEVPKLLDGLRATWAGYVPAILHSSGLSHIGQVIAHIPEQALEALPITYPEVSQFVSENLAQILALGVAFSPTRLAPLRIEVRDLSSVGGFPEVARFLFEGGFYTLSIENLQFIFHEFLGANDLAPLRTQNFTMLTGTGNSSLISRIEHGFDLYLKDVLHPMKSDTNESVTAILDLLGREDADFEIMSAILERQFATIQSFDSVPVRFQSLVFQLGRIEASWENCLKYMSCDAFDAGILTGFLETKAALEALTAQPIAGDDKNAKLRWFLINNNALEDPTYLAYVKRLPKPFTQFPSELDFSKWRILIEQSRIVFSKNTVLALGEQDELQTLFVVKNIDKYLMGVDEFELDDDFRERLLAENIRDDQKLAVIQAMDLSSLGAMPVRAGQVGMIIEKTGANTAMLNAEGARAAIVNSAPVRVQISLFNKCERILSSGDVRGILAELPRPFSEINSGYHKPTIENNSENVEFVEWLKRRKIISSWKVSLLGDIRIYLFRSIGNR
>NZ_CP018756.1|WP_079221631.1|1493720_1494623_-|LysR-family-transcriptional-regulator
MSRKFDYLGDVEVFLAVVEHGSFTAGAVALSTTPSVLSRAVTRLEARLGRQLLQRTTRRVGLTDAGRLYLEQVRTAFGLLDDAERDVQAQDGALAGRVRLSVPTTYGHYRLPPVLARFAQQYPQVQVELNITNRNVDLVAEGFDLAIRLGQLPDSGLVGRKLEDAALVLVASPEYLERRGMPQSLEDLEQHLCLPFVMPRTGRLAPWVFRDGGRDVDWLPRSSIETSDDVLGVVSLAERAIGICQSYEFIVRERLLRGELVEVLPQLRGRSRPFSVIYAPHRWQSAAARAMIELLVEMRG
>NZ_CP018756.1|WP_079221632.1|1494717_1495557_+|type-1-glutamine-amidotransferase-domain-containing-protein
MNLMTRLAAALALTLAATGAHAANVLVVLSDENHLDLKDGKVLSTGFYLNELMQPVKLLLDAGHEVTFATPQGRAPTVDASSVTPAYFGNDTAQLKLHKELLEKLALTSPTASPVVSLARVEQQGYAWFDAVYIPGGHAPMQDLLKSPALGRLLAEFHQRNKSTALVCHGPIALLSTLPDANGFVAKLEAGDMPTTPKWIYSGYQMTVISNQEEEQAKPMLGGGEMKFYPQTALQRAGAKFSSNTTPWTGHVVVDRELITGQNPASALEVGQRLVERLK
>NZ_CP018756.1|WP_079221633.1|1495869_1496181_+|hypothetical-protein
MTLVMVDGKEDREHYFFDTETFYMQRGPVPTVVPLAQITSVTRTSDVIYGRYVWQVCFSKAAGRKCVTFTNNLTLFNRDFLAFLEAVRKANPLATVDRAGLRF
>NZ_CP018756.1|WP_079221634.1|1496257_1497040_+|3-hydroxybutyrate-dehydrogenase
MLSGKVAVVTGSTSGIGLGIATALARQGADIVLNGFGDAQDIERIRSSLEAEFGVRVAHDGADLSHGEAVREMIDRAVATLGRIDILVNNAGIQHTASIEEFPVEKWDAILALNLSAVFHATAAALPHMKQQGWGRIINIASAHGLVGSVNKSAYVAAKHGVVGFTKVTALENAGAGITANAICPGWVRTPLVEKQITALAEREGTDQESAARELLAEKQPSLQFVTPEQLGDLVVFLASDAAAQMTGTALPMDGGWTAR
>NZ_CP018756.1|WP_079221635.1|1497177_1497534_-|hypothetical-protein
MTTRKNPPLHAVGTVNDDENPTSDLSTFQGCLTRIRDGEGSDGMLWPEENLSDGRRQSLARIDRAATGILTAVEMLHAANRCKTMATPRRHLDEGVVEGLFFACRELAELVCREVRPT
>NZ_CP018756.1|WP_079221636.1|1498195_1499272_-|DUF4263-domain-containing-protein
MKITDTVLSYAGENHPKSTGICRLRVFAAQGGPRVLITDLGECNDGPSVTNAIETIIKRVQESGLALGASIYIEHYEKADATTDTFDQVDVSHGTQWKPLSKDAAIAALGCSADELEERTGCNKRIVRTAEALRLARKPFDGSPWPEPAHVTKRKLKIFDGMISAASVDALVQAGSGERELQRLLKQDLSIMAEGLSSPEGEYICFSELPLGDGYVDFAVFTGRSRMDVILIEVKGADFNLLNSNHYQAFNHKVQEAAGQLRDRVGVVYRNYDSVRRELHRIRLEAERGSPLYNAFLGPVGLLQVDPDKDINIRSIVIGGRTQNDREESRKRQDYELNTSPRVRLESWDTWLRRLQRA
>NZ_CP018756.1|WP_079221637.1|1499557_1499857_-|hypothetical-protein
MTPPSAFRILRIRPLLRLDGTIDRVEALHCKCTHCGDEARYSEPGGLRHVESEIELTCPACGTTGRFTNAQLFAAWVQQVRRDRVLALAGIDPEKLYGP

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Crispr_ID: NZ_CP018756_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_9

1497059-1497174

Orphan

Consensus_repeat	Method
TTTGATTTCCCGCCGGGCATGGCCCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_9

>merge|NZ_CP018756|9|1497059-1497174|CRISPRCasFinder
TTTGATTTCCCGCCGGGCATGGCCCGGCGCTACCGGATGGGGTGGTGGTAGCGCGGGACCGTGCCCCGCGAGCGCGCAGCGCGGTGTTTTGATTTCCCGCCGGGCATGGCGCGGCG

>NZ_CP018756|9|9|1497059-1497174|CRISPRCasFinder
TTTGATTTCCCGCCGGGCATGGCCCGGCG	CTACCGGATGGGGTGGTGGTAGCGCGGGACCGTGCCCCGCGAGCGCGCAGCGCGGTGT
TTTGATTTCCCGCCGGGCATGGCGCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221629.1\|1487498_1489064_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP018756.1\|WP_079221626.1\|1481413_1482550_+\|molybdopterin-synthase-adenylyltransferase-MoeB	unknown	unknown	gnl\|CDD\|236337
NZ_CP018756.1\|WP_079221638.1\|1500125_1501013_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NZ_CP018756.1\|WP_079221639.1\|1501145_1501889_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187620
NZ_CP018756.1\|WP_152027174.1\|1489831_1493266_+\|ATP-binding-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225193.1\|1503913_1505653_-\|sensor-domain-containing-phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NZ_CP018756.1\|WP_079221641.1\|1502317_1502665_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP018756.1\|WP_079221627.1\|1482716_1484552_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|235131
NZ_CP018756.1\|WP_079221640.1\|1501910_1502312_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NZ_CP018756.1\|WP_079221635.1\|1497177_1497534_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225191.1\|1485931_1487389_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NZ_CP018756.1\|WP_079221628.1\|1484711_1485590_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	unknown	unknown	gnl\|CDD\|236760
NZ_CP018756.1\|WP_079221636.1\|1498195_1499272_-\|DUF4263-domain-containing-protein	unknown	unknown	gnl\|CDD\|372906
NZ_CP018756.1\|WP_161490369.1\|1503353_1503800_-\|chemotaxis-protein-CheW	unknown	unknown	gnl\|CDD\|366716
NZ_CP018756.1\|WP_079221634.1\|1496257_1497040_+\|3-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|187644
NZ_CP018756.1\|WP_079221632.1\|1494717_1495557_+\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
NZ_CP018756.1\|WP_079221642.1\|1502701_1503079_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NZ_CP018756.1\|WP_079221637.1\|1499557_1499857_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221631.1\|1493720_1494623_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP018756.1\|WP_079221633.1\|1495869_1496181_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221629.1\|1487498_1489064_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP018756.1\|WP_079221634.1\|1496257_1497040_+\|3-hydroxybutyrate-dehydrogenase	gnl\|CDD\|187644	cd08940, HBDH_SDR_c, d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs. DHBDH, an NAD+ -dependent enzyme, catalyzes the interconversion of D-3-hydroxybutyrate and acetoacetate. It is a classical SDR, with the canonical NAD-binding motif and active site tetrad. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	9.57613e-153
NZ_CP018756.1\|WP_079221626.1\|1481413_1482550_+\|molybdopterin-synthase-adenylyltransferase-MoeB	gnl\|CDD\|236337	PRK08762, PRK08762, molybdopterin-synthase adenylyltransferase MoeB.	0
NZ_CP018756.1\|WP_079221638.1\|1500125_1501013_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	3.29261e-54
NZ_CP018756.1\|WP_079225193.1\|1503913_1505653_-\|sensor-domain-containing-phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.95757e-86
NZ_CP018756.1\|WP_079221641.1\|1502317_1502665_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000134892
NZ_CP018756.1\|WP_079221627.1\|1482716_1484552_+\|cation:proton-antiporter	gnl\|CDD\|235131	PRK03562, PRK03562, glutathione-regulated potassium-efflux system protein KefC; Provisional.	0
NZ_CP018756.1\|WP_079221640.1\|1501910_1502312_+\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.05545e-27
NZ_CP018756.1\|WP_079221639.1\|1501145_1501889_+\|SDR-family-oxidoreductase	gnl\|CDD\|187620	cd05362, THN_reductase-like_SDR_c, tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs. 1,3,6,8-tetrahydroxynaphthalene reductase (4HNR) of Magnaporthe grisea and the related 1,3,8-trihydroxynaphthalene reductase (3HNR) are typical members of the SDR family containing the canonical glycine rich NAD(P)-binding site and active site tetrad, and function in fungal melanin biosynthesis. This subgroup also includes an SDR from Norway spruce that may function to protect against both biotic and abitoic stress. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.56478e-64
NZ_CP018756.1\|WP_079225191.1\|1485931_1487389_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NZ_CP018756.1\|WP_079221628.1\|1484711_1485590_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	gnl\|CDD\|236760	PRK10792, PRK10792, bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD.	0
NZ_CP018756.1\|WP_161490369.1\|1503353_1503800_-\|chemotaxis-protein-CheW	gnl\|CDD\|366716	pfam01584, CheW, CheW-like domain. CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.	1.47689e-13
NZ_CP018756.1\|WP_079221636.1\|1498195_1499272_-\|DUF4263-domain-containing-protein	gnl\|CDD\|372906	pfam14082, DUF4263, Domain of unknown function (DUF4263). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 244 and 403 amino acids in length.	1.01014e-18
NZ_CP018756.1\|WP_079221632.1\|1494717_1495557_+\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	2.11311e-73
NZ_CP018756.1\|WP_079221642.1\|1502701_1503079_+\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.29552e-35
NZ_CP018756.1\|WP_079221631.1\|1493720_1494623_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.64821e-69

>NZ_CP018756.1|WP_079221634.1|1496257_1497040_+|3-hydroxybutyrate-dehydrogenase
MLSGKVAVVTGSTSGIGLGIATALARQGADIVLNGFGDAQDIERIRSSLEAEFGVRVAHDGADLSHGEAVREMIDRAVATLGRIDILVNNAGIQHTASIEEFPVEKWDAILALNLSAVFHATAAALPHMKQQGWGRIINIASAHGLVGSVNKSAYVAAKHGVVGFTKVTALENAGAGITANAICPGWVRTPLVEKQITALAEREGTDQESAARELLAEKQPSLQFVTPEQLGDLVVFLASDAAAQMTGTALPMDGGWTAR
>NZ_CP018756.1|WP_079221633.1|1495869_1496181_+|hypothetical-protein
MTLVMVDGKEDREHYFFDTETFYMQRGPVPTVVPLAQITSVTRTSDVIYGRYVWQVCFSKAAGRKCVTFTNNLTLFNRDFLAFLEAVRKANPLATVDRAGLRF
>NZ_CP018756.1|WP_079221632.1|1494717_1495557_+|type-1-glutamine-amidotransferase-domain-containing-protein
MNLMTRLAAALALTLAATGAHAANVLVVLSDENHLDLKDGKVLSTGFYLNELMQPVKLLLDAGHEVTFATPQGRAPTVDASSVTPAYFGNDTAQLKLHKELLEKLALTSPTASPVVSLARVEQQGYAWFDAVYIPGGHAPMQDLLKSPALGRLLAEFHQRNKSTALVCHGPIALLSTLPDANGFVAKLEAGDMPTTPKWIYSGYQMTVISNQEEEQAKPMLGGGEMKFYPQTALQRAGAKFSSNTTPWTGHVVVDRELITGQNPASALEVGQRLVERLK
>NZ_CP018756.1|WP_079221631.1|1493720_1494623_-|LysR-family-transcriptional-regulator
MSRKFDYLGDVEVFLAVVEHGSFTAGAVALSTTPSVLSRAVTRLEARLGRQLLQRTTRRVGLTDAGRLYLEQVRTAFGLLDDAERDVQAQDGALAGRVRLSVPTTYGHYRLPPVLARFAQQYPQVQVELNITNRNVDLVAEGFDLAIRLGQLPDSGLVGRKLEDAALVLVASPEYLERRGMPQSLEDLEQHLCLPFVMPRTGRLAPWVFRDGGRDVDWLPRSSIETSDDVLGVVSLAERAIGICQSYEFIVRERLLRGELVEVLPQLRGRSRPFSVIYAPHRWQSAAARAMIELLVEMRG
>NZ_CP018756.1|WP_152027174.1|1489831_1493266_+|ATP-binding-protein
MSNIALTGPYGSGKSSIIKSFVKKYRRPALQISLAAFLTEDTSSKQKVSKQEIERSILQQMLYGADANQLPLSRFKRIKSPSKWSILFSFFAIVGATAFWVIYQRRGEVIDGTYFLPVSISNWANYLWFAIGASFLWVAVYRAYKASFGVSLKSVSLKDIEITPAAVSQESILNRHLDEIIYFFQSTDYDLVIIEDLDRFNDSDIFVTLREINSLVNANAGVKRPIRFLYALRDDMFISTERTKFFEFIIPVIPIINSSNSIDKVLEQGKRLSIDSRLDQRFLREVSRYLNDLRLIHNIFNEYAIYVANLELDDDNVLDATKLLAVLIYKNVFPRDFESLHRGKGNLAKILARHDEFIARAEEKNREKIDEIEGRLASADRQVPTDLLELRRIYAMALVERLPASSYRVGQNGQSMIEIGDLARSESFDQIISSRRVVVAVNNYYGSSNQNVDISGLQEDVDSQRAFGDRQKEIQRRAADFKSSAAKKLQVLRAASAKLRSSKFSEIIRINIDDLDGIFEGFGEGHELARFLILEGHVDDTYYQYTSLFHAGRMSPNDNKFLIQIRGFIVPDPSFPIDNVKEVVAGMRDEDFRQPYVLNVKVVDCLLGNSTTYKDQLAKMFDYMASNFEGCAAFFASYYVAGAEVPKLLDGLRATWAGYVPAILHSSGLSHIGQVIAHIPEQALEALPITYPEVSQFVSENLAQILALGVAFSPTRLAPLRIEVRDLSSVGGFPEVARFLFEGGFYTLSIENLQFIFHEFLGANDLAPLRTQNFTMLTGTGNSSLISRIEHGFDLYLKDVLHPMKSDTNESVTAILDLLGREDADFEIMSAILERQFATIQSFDSVPVRFQSLVFQLGRIEASWENCLKYMSCDAFDAGILTGFLETKAALEALTAQPIAGDDKNAKLRWFLINNNALEDPTYLAYVKRLPKPFTQFPSELDFSKWRILIEQSRIVFSKNTVLALGEQDELQTLFVVKNIDKYLMGVDEFELDDDFRERLLAENIRDDQKLAVIQAMDLSSLGAMPVRAGQVGMIIEKTGANTAMLNAEGARAAIVNSAPVRVQISLFNKCERILSSGDVRGILAELPRPFSEINSGYHKPTIENNSENVEFVEWLKRRKIISSWKVSLLGDIRIYLFRSIGNR
>NZ_CP018756.1|WP_079221629.1|1487498_1489064_+|glutamine-hydrolyzing-GMP-synthase
MTNIHNDKILILDFGAQYTQLIARRIRELGVYCEIWAWDHNPAEIAAFGAKGIILSGGPESTTLPGAPAAPQEVFDSGLPIFGICYGMQTLAAQLGGATEAADQREFGHAEVNVINPDALFKGLGDHGGEPKLNVWMSHGDHVSVAPPGFTITATTDRIPVAAMANEEKRWYGVQFHPEVTHTLQGQALLRRFVVDVCGCQTLWTAANIIDDQIARVREQVGDDEVILGLSGGVDSSVVAALLHKAIGEKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVVRVNAADRYFSALEGVSDPEAKRKIIGNLFVEIFDEESNKLKNAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFPGPGLGVRILGEVKREYAELLAKADAIFIDELRKADLYDKTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAHWAHLPYEFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE
>NZ_CP018756.1|WP_079225191.1|1485931_1487389_+|IMP-dehydrogenase
MLRIQAEALTYDDVSLVPAHSTILPKDVNLETRLTRDLKLKLPILSAAMDTVTEARLAIAMAQLGGMGIIHKNLSLEQQAAEVAKVKKFEAGVIRDPITVGPETTIRDVLALTQAHNISGVPVVGSDGLLAGIVTHRDMRFETELDDPVRHIMTKKDRLVTVKEGAASDEVLQLLHRNRIEKVLVVNDDFALRGLITVKDIQKNTDFPNAAKDLSTRLLVGAAVGVGGDTDRRVEALVAAGVDVIVVDTAHGHSQGVLDRVAWVKKNFPNVQVIGGNICTGEAALALLDSGADAVKVGIGPGSICTTRVVAGVGVPQVTAIDLVAEALQDRIPLIADGGIRYSGDIGKALAAGASTIMVGGLLAGTEESPGETELYQGRSYKSYRGMGSLAAMEKGSKDRYFQDAATADKLVPEGIEGRVPYRGPVGGIIHQLMGGLRATMGYVGCATIDDMRTKPKFVKISGAGQRESHVHDVTITKEPPNYRA
>NZ_CP018756.1|WP_079221628.1|1484711_1485590_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD
MTDSAPQLPARILDGRRIAEDLLDSLKVRVDARVAAGGSRPGLAVVLVGGDPASTVYVRNKRRAAEKVGIEAHDYDLPAGTSEAELLDLIDQLNADPKINGILIQLPLPGIPDARRLIQRIDPRKDVDGFHPENVGHLALREFGLRPCTPRGITTLLGHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPKDVLEQAVRNADILVVAVGRPGIVPGEWVKPGAVVIDVGINRLDDGRLVGDVGFEAAAERASWITPVPGGVGPMTVATLMQNTLEAAEALS
>NZ_CP018756.1|WP_079221627.1|1482716_1484552_+|cation:proton-antiporter
MAVEAATSELVKVVALLGAAVVMVPLFRRLGLGSVLGYFAAGLAIGPFGLGWFSDPQAILHTAELGVVMFLFVIGLEMRPSHLWSLRKEIFGLGTLQIATCALVLTTIAKLFGLPWQVAFIGATGFVLTSTAVVMQLLAERGDIALPSGQKIVSILLFEDLLIVPLLALVAWMAPSAGSADGEGSRWLSVAIGVGAIVGLVLVGRFLLNPLFRLLAESKAREVMTAAALLVVLGAALLMQLSGLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLSVGMALDLGVVAGNWPMIVGLVLALMAAKALCIYVVARLMGSDHAQAMDRGVLMAQGGEFAFVLFSAAASAGVIDMDINANFTAVVVLSMALTPLVVLVYKRVAPKPEVSLEGVDTADGLSGSVLMIGFGRFGQVASQSLLARDVDVTIIDNDVEMIHNAERFGFKIYYGDGTRLDVLHASGAGTARAIAVCVNNAEDADRIVELVAHEFPQAKLLVRSFDREHSLRLIHAGVDFQIRETFESALMFGQAALMELGADEDDAQEIAEQIRERDAERFELEMAGGSLRAGAHMVFGSALPGVPTPTPFTAPKRKARTLNADQVPEEEED
>NZ_CP018756.1|WP_079221626.1|1481413_1482550_+|molybdopterin-synthase-adenylyltransferase-MoeB
MSIPELSPEQARARVAHGAVLIDVRQAHERAGGMAEGARGVAKDDLLADPAAHLPAPGQEILLICQSGKRSADAAQALLAAGYSNVASVAGGTVAWREQALPLVQPMLDAADRDFYDRYSRHLLLPQVGEAGQRRLQQSRVLVLGAGGLGAPAGFYLAAAGVGHLRFADHDRVERSNLHRQIVHTEASVGQLKVDSARERLLALNPSIEVEAVPERVTSENVDRLLDGVDVVLDGSDNFPLRYLLNDACIKHAKPMVYAAIERFDGQVSVFDAGRQRGVAPCYRCLFPEPPPPEFAPNCSEAGVLGVLPGLAGVLQATEVLKLLLGIGEPLVGRLLRFDALGMRFRETGIGPDPACPVCAPGVLFPGYIDYTALCSGG
>NZ_CP018756.1|WP_079221635.1|1497177_1497534_-|hypothetical-protein
MTTRKNPPLHAVGTVNDDENPTSDLSTFQGCLTRIRDGEGSDGMLWPEENLSDGRRQSLARIDRAATGILTAVEMLHAANRCKTMATPRRHLDEGVVEGLFFACRELAELVCREVRPT
>NZ_CP018756.1|WP_079221636.1|1498195_1499272_-|DUF4263-domain-containing-protein
MKITDTVLSYAGENHPKSTGICRLRVFAAQGGPRVLITDLGECNDGPSVTNAIETIIKRVQESGLALGASIYIEHYEKADATTDTFDQVDVSHGTQWKPLSKDAAIAALGCSADELEERTGCNKRIVRTAEALRLARKPFDGSPWPEPAHVTKRKLKIFDGMISAASVDALVQAGSGERELQRLLKQDLSIMAEGLSSPEGEYICFSELPLGDGYVDFAVFTGRSRMDVILIEVKGADFNLLNSNHYQAFNHKVQEAAGQLRDRVGVVYRNYDSVRRELHRIRLEAERGSPLYNAFLGPVGLLQVDPDKDINIRSIVIGGRTQNDREESRKRQDYELNTSPRVRLESWDTWLRRLQRA
>NZ_CP018756.1|WP_079221637.1|1499557_1499857_-|hypothetical-protein
MTPPSAFRILRIRPLLRLDGTIDRVEALHCKCTHCGDEARYSEPGGLRHVESEIELTCPACGTTGRFTNAQLFAAWVQQVRRDRVLALAGIDPEKLYGP
>NZ_CP018756.1|WP_079221638.1|1500125_1501013_-|AraC-family-transcriptional-regulator
MDSLLEELRVLTAHAQNRRTETGIPRVSMVQGAVPEHELAAVYEPMVNLILQGSKSMTVGAQTLHYDPATYFVMSVDLPAAGVVCSSPAGAPYLAVALSLDPVLLATLLNDLAEPATNPQTRGFSVAAVTPQLLDAWARLLRLMKYPDDIAALAPAYEREILYRVLQGPMGWMLRDIASPDSALARVNHAIQAIRRDYARSWRVEELAADAAMSVSAFHRHFKAVTSLSPVQYQKQVRLLQARTHLLASGCSVIRAAHTVGYESPTQFSREYARAFGQSPAKDIARIQQRSRSNG
>NZ_CP018756.1|WP_079221639.1|1501145_1501889_+|SDR-family-oxidoreductase
MPITLITGGSRGIGASIALACARRGHGVILTYQQNVEAADAVVRQIANAGGRAIALPLDVGRVQSFAGFRADVERVLASEWSEGQLSGLVNNAGHGLFNPIATVSEAQFDGLFNVHLKGPFFLTQALLPLLAPQAAIVNITSATTRVATVGVAPYASFKGGLEVLTRYMAKEFGPQGIRVNSVSPGPIRTELGGGLDEASETALASQTALGRVGEPDEVGSVVASLLSSESGWVTAQNIEVSGGYVI
>NZ_CP018756.1|WP_079221640.1|1501910_1502312_+|VOC-family-protein
MLDHLFLTVADTSRAVAFYARVLPVLGIDRRLDYDGSQGPPGHPDLKGFGADGRVFFWLRQGQPAPEAVHVGFAAKSTAKVDAAFAAALDAGATVIHPPGAQHHYDPRYYAAQVRDLDGYSLEFVHKPWQHGA
>NZ_CP018756.1|WP_079221641.1|1502317_1502665_+|nuclear-transport-factor-2-family-protein
MRGSRDGLQQAAHALVAATNAFDVDTALSLFADDAVIDDPSTGERFEGVAGVREYIERYFVAYHTVTRILSVEPDTRAQACVRVDFKGDFGHETGRLVIVLDAAGRIRRIDADLD
>NZ_CP018756.1|WP_079221642.1|1502701_1503079_+|VOC-family-protein
MSLLDHVEFAVSDARASQAFYARALAPLGMVHLVHVQTAAGGDRHGFGREGYPCLWFHDQDVLGHGTHIAFAAATRAQVDAFHRAALAAGGMDNGAPGVRERYHPGYYAAYVLDPDGVNVEVVCQ
>NZ_CP018756.1|WP_161490369.1|1503353_1503800_-|chemotaxis-protein-CheW
MQPSSPSAGSPASPSRPFFEYLAVRAGEQWFAVDVQATVEIRGPETFDRPGSEGRLTLTVRENALRVVDLRRLSGLTPFTYTCPAMALVRAGVDVIGLAVDEVGDIESVPRKQLRADNPLGYVFCSQSIAMPDKREIPLIDPMLLISA
>NZ_CP018756.1|WP_079225193.1|1503913_1505653_-|sensor-domain-containing-phosphodiesterase
MSTLGSLDVLDDVAGASLDRLTDLAARTFHAPVAFVSLIEVDRQRLISRKGLTSAGSHIRDSICAHTIGSTAGLVINDLALDPRFSSLPLVAGPPHLRFYAGTPLIAANGVAIGALCVMDSVPRQFSADDRRQLQTLGMAVMNELELRTLSGRRDPVSGLPNRHQFAIDYAARSVRTPGRPCYAVMIDVLDLPRANEAGQVLGMVPLEALIRRAGVRINLALDGVAQVYHVEATRFAFVIELPDRDAIERLVHLLHDDLIRPIMAAAVPLAPQFHAGLCEATLGRDSADDVLRKMMIGMHSALAGHVTCCWYSSLRDEGLQRSYRLATDGQQALQQDQFHLVYQPRFRAEDLTPVSAEVLLRWDHPQLGAVSPAEFIPVFERTALMDGVTAWVLDHAFTQLAQWRREGLSLTLSINLSARDVARKGMADAFIATLLCKGLSCTDVEVEITEGEWLRADSLPGEQLKQLAAAGVRVAIDDFGSGYSNFGYLTELPIHTIKLDKSMIDDLPTDTRAQLKVQAVIGLAHGLGYNTVGEGAETFEQVALLQAYGCDEIQGFALSRPVSATDLAALQTVPYVPA

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Crispr_ID: NZ_CP018756_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_10

1780596-1780705

Orphan

Consensus_repeat	Method
GCCACGACCCGCGATCATCCACGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_10

>merge|NZ_CP018756|10|1780596-1780705|CRISPRCasFinder
GCCACGACCCGCGATCATCCACGCACGGCGTGGATCTACTACCGGGCTGCGCCCTGGTGGGTGCCGACCGTTGGTCGGCACTGACGCCACGACCCGCGACCATCCACGCA

>NZ_CP018756|10|10|1780596-1780705|CRISPRCasFinder
GCCACGACCCGCGATCATCCACGCA	CGGCGTGGATCTACTACCGGGCTGCGCCCTGGTGGGTGCCGACCGTTGGTCGGCACTGAC
GCCACGACCCGCGACCATCCACGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221854.1\|1781411_1781759_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221861.1\|1786346_1786673_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP018756.1\|WP_079221851.1\|1775556_1777659_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP018756.1\|WP_079221846.1\|1771000_1771657_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	unknown	unknown	gnl\|CDD\|183625
NZ_CP018756.1\|WP_079221849.1\|1772465_1773683_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|340419
NZ_CP018756.1\|WP_079221853.1\|1780782_1781274_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221847.1\|1771732_1772038_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|274802
NZ_CP018756.1\|WP_079221859.1\|1785284_1785746_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239647
NZ_CP018756.1\|WP_079221845.1\|1769770_1770715_-\|chemotaxis-protein-CheV	unknown	unknown	gnl\|CDD\|223905
NZ_CP018756.1\|WP_079221843.1\|1768826_1769234_-\|flagellar-basal-body-rod-protein-FlgC	unknown	unknown	gnl\|CDD\|183634
NZ_CP018756.1\|WP_079221862.1\|1787009_1789292_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	unknown	unknown	gnl\|CDD\|236828
NZ_CP018756.1\|WP_079221848.1\|1772034_1772373_+\|flagellar-protein-FlgN	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221852.1\|1777790_1780529_+\|phosphodiesterase	unknown	unknown	gnl\|CDD\|236645
NZ_CP018756.1\|WP_079221844.1\|1769237_1769633_-\|flagellar-basal-body-rod-protein-FlgB	unknown	unknown	gnl\|CDD\|183628
NZ_CP018756.1\|WP_079221858.1\|1784145_1785288_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP018756.1\|WP_079221850.1\|1773777_1775553_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP018756.1\|WP_079221856.1\|1782170_1783361_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|206779
NZ_CP018756.1\|WP_079221857.1\|1783534_1784149_-\|high-frequency-lysogenization-protein-HflD	unknown	unknown	gnl\|CDD\|234690
NZ_CP018756.1\|WP_079221860.1\|1785747_1786236_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221855.1\|1781856_1782072_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221851.1\|1775556_1777659_-\|PAS-domain-S-box-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.7336e-41
NZ_CP018756.1\|WP_079221846.1\|1771000_1771657_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	gnl\|CDD\|183625	PRK12617, flgA, flagellar basal body P-ring formation protein FlgA.	5.00115e-101
NZ_CP018756.1\|WP_079221849.1\|1772465_1773683_+\|PAS-domain-containing-protein	gnl\|CDD\|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	6.65604e-52
NZ_CP018756.1\|WP_079221847.1\|1771732_1772038_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|274802	TIGR03824, FlgM_jcvi, flagellar biosynthesis anti-sigma factor FlgM. FlgM interacts with and inhibits the alternative sigma factor sigma(28) FliA. The C-terminus of FlgM contains the sigma(28)-binding domain.	7.70632e-15
NZ_CP018756.1\|WP_079221859.1\|1785284_1785746_-\|NUDIX-hydrolase	gnl\|CDD\|239647	cd03675, Nudix_Hydrolase_2, Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.0077e-72
NZ_CP018756.1\|WP_079221845.1\|1769770_1770715_-\|chemotaxis-protein-CheV	gnl\|CDD\|223905	COG0835, CheW, Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms].	1.21133e-37
NZ_CP018756.1\|WP_079221843.1\|1768826_1769234_-\|flagellar-basal-body-rod-protein-FlgC	gnl\|CDD\|183634	PRK12629, flgC, flagellar basal body rod protein FlgC; Provisional.	7.13272e-80
NZ_CP018756.1\|WP_079221862.1\|1787009_1789292_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	gnl\|CDD\|236828	PRK11034, clpA, ATP-dependent Clp protease ATP-binding subunit; Provisional.	0
NZ_CP018756.1\|WP_079221861.1\|1786346_1786673_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	2.59732e-43
NZ_CP018756.1\|WP_079221852.1\|1777790_1780529_+\|phosphodiesterase	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	5.51184e-102
NZ_CP018756.1\|WP_079221844.1\|1769237_1769633_-\|flagellar-basal-body-rod-protein-FlgB	gnl\|CDD\|183628	PRK12620, flgB, flagellar basal body rod protein FlgB; Provisional.	2.07986e-77
NZ_CP018756.1\|WP_079221858.1\|1784145_1785288_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP018756.1\|WP_079221850.1\|1773777_1775553_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	4.56419e-97
NZ_CP018756.1\|WP_079221857.1\|1783534_1784149_-\|high-frequency-lysogenization-protein-HflD	gnl\|CDD\|234690	PRK00218, PRK00218, lysogenization regulator HflD.	4.76792e-83
NZ_CP018756.1\|WP_079221856.1\|1782170_1783361_-\|chemotaxis-protein	gnl\|CDD\|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	4.99071e-31

>NZ_CP018756.1|WP_079221852.1|1777790_1780529_+|phosphodiesterase
MDQGIIASLLQHPLASALVIVDRGGRPLAANAAAREHGLPSTVAAYAPMLEDLRLLAADGGIVACTLPGGPRGHYDGYLRAVHDGSGNLLAFTLSVPEPVPVDAGGRWELALESAGHSLWDWDIPSDRVVRTPALVDETANAIIARVHSDDLGDMRAALDEHLRGHSEQYSAQFRFRQEDGQWRWVLDRGRVVARTADGQPLRMVGTHTDIEQQKQLEALLQEQQLHLSEAQRIASMGSWSFDPTNHRFWWSPELRSLLALEPGEVPGQRRWLKQLHPRSRGALRAAWRRLWRDGRAANLELELTRGSEPSQHLRLWMQPLLDMDGHPKRLLGQVQNITEQHQTDALIRWRTELLNRVSALGRIGGCEIEVSTRHMQWTEECYRIHGLRKEPITLDQALALYTEDSRAHFEAALQRIAGGGLPEQLDLCFYRQSGLRVWVQVLIELDRRDGLPPRFVVLFRDITREREANERIELLAHYDLLTGLPNRVLLGEQTAEAIEEARDRGTSLAMLFIDLDGFKTINDSFGHATGDALLKAAATRLHQNLRNNDLFGRFSGDEFIVVLRDLAEPEDAGHVARKLIGSLAEPLRRGDTTLKVGASVGIAMLGDTQTDFDSLLRAADAAMYAAKEAGRNTYQYYSQDALARIQRRLEIEHGLHGAIEREEFSLAYQPLLHAHHDEPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLSEACRQASAWDRAGLRFERIAVNVSAVQLRDRGFAERVIEICHAHGWPPQRLELELTESALIRDTDILRHCFDVLERHGVPLAVDDFGTGFSNLHYLNRFPVGRLKIDRSFVQGMLHDTGTAEVTQAIVHLGHALGMKVVAEGVETHQEEDMLRRQGCDEIQGYLYSRPLSPRDLALWLRQQHAAPEVALAR
>NZ_CP018756.1|WP_079221851.1|1775556_1777659_-|PAS-domain-S-box-protein
MPAEPTGTAPAPDPQMAKALGRDRRRVVLSYLVLALAWMIATDGAMAALVPDPQQLAFWQTVKDAFFAFASAGLLYLLLRPLAEHVLRTHTRLQGSELRLRQLFEGNPGPILVYDLDSLAILDANPAACLAFGWERDELLQQAIDVLWAPGDRLVLQAKLEAIREAPEQICILRTPLQLRDGSVRQMELRSNAIDYDGRNARLLIAIDRTAEDLAQLRRDQALARVEEAHELARIGAWELDPASGLGRYSNQVYRLLGRRPPEARRWHRFDELLVPADPTTAAQTEQLLAELCTSPTAQVDVLLPVLSMDGRSLMVHLRAASGLDEAGRERVLGTLQDVTEREQSRRLLREREEQFRELVRVLPDGVVILSEEHVLYANAWAAALFGYGSHTLLGEPLDALVDPTELDRVRVQLRAGQPQHSPGHNSVVVMQRADGRRFHAGLAVGEVRYGGRDCKLLIVRDLSESERTRTALETSNRELQAMAGRLFSLQEDERRAISRDLHDDIGQAITAIKLSAYAAQDEEDAQRRGEDLAQIVSLADTTVGKLRDISTLLRPPQLDALGLEAALSWQARVLFRSSPVELLAEIDTLPSRPDNSIEQACFRIAQESLTNVLRHARASQVQLQLRDVDQRGLHLQIRDDGEGFDPDGPRGLGLIVMRERAQSVGGHVHIESAHGAGTLVDVHLPYQAATAAAADSPEY
>NZ_CP018756.1|WP_079221850.1|1773777_1775553_-|EAL-domain-containing-protein
MWNPNMPLVSIDDAPDRLGAGNPELQVMVTEAASGGTPLMLMHVDIDHFASVNENMSADVGDQALVLVAQRLQSYLRGRGKLWRHGSDEFLLAVPRTADLPLPEDFAEEIRQQMELPLSVLPYTLFMTGKLGVSLCPEHASSASRLLDHAEDALYQAAREGGNAVRIHAVDTPPSAHSESIIARQIVDAIPNGELKLRYQPLVSARDGHVVGMEALLRWQSPTLGMLVPERFMRTAERLGIIVQIGTWVLEGALKQARLWRDQGFDDFTIAVNVSTLQLLRPNFFAEVMGLIQAAGVPAQMLTLEINESALTNNVNFVHETLANLRNEGISLSLDNFGTGDSSLSALVRYPVDKLKIDRSFIKSAPAGNREAAIARAIIAMGHQLGMTVIANGVESQAQLGFLRRNDCDVFQGYLFGEPMSADAAGMTLRRRYLRPEAFAETRPDRTLLLLDDEENVLRSLVRLFRRDGYRILAAGNVRDAFDLLAINDVQVILSDQRMSDMSGTEFLGRVKMLYPDTIRLVLSGYTDLNTVTDAINRGAIYRFLTKPWNDDELRKHIHQAFRTYEEQRRSNAGPTPVEAGDAGEDRTPLR
>NZ_CP018756.1|WP_079221849.1|1772465_1773683_+|PAS-domain-containing-protein
MSAANALVTAPLPPQPVLQALLERLREGLLLFTEDGQVALANPAAQNLLGSEEAAAAAPQRLRELLPPDALEQARLHGQWNGSLPVGEGVVIAHLYHHGQPGSGHYLALFRPIEGQEDYERELQQRHAELRQAYLRLNGTQEKLLQSEKMASIGQLAAGVAHEINNPIGYVHSNLGSLQEYLRSLFTVIEAYERALRAPDPKALIPEIDDIRDRLDIDFISRDLPQLMAESREGIERVTRIVRDLKDFSYSGRDESWKLVDLHSGLESTINIIWNELKYKVTLHREFGQLPLVECLPSELNQVYMNLLLNAGHAIAERGTITVRTGVDGDTVWVEFEDTGGGISPELRQRIFDPFFTTKPVGSGTGLGLSISYSIINKHHGRIDLDSTPGVGSRFRVVLPVKQPR
>NZ_CP018756.1|WP_079221848.1|1772034_1772373_+|flagellar-protein-FlgN
MTAAMSEHLQRLAQALDVEHQALVEHDVHALIRATGAKLEALRALDSTPPLGEAEQLQALAERNRANGVLLSRRRREVDWALRQLGRTEASSSYDAKGQAHTVNARRPLAVA
>NZ_CP018756.1|WP_079221847.1|1771732_1772038_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MSQKIDGNLQVPQALRSVTTPATKPGVSGDAPARPVEAADSLRLTGEATNLQALERELSTAPAIDTQRVAAVRESLQNGSYKINPDAIASRMLELDQQLQG
>NZ_CP018756.1|WP_079221846.1|1771000_1771657_+|flagellar-basal-body-P-ring-formation-protein-FlgA
MRRITSLLGIALALASPWAAAVDWQPVASIRTAALSTLAAGSEGEAVVADALRLPRCGAALQVQPTANTTVEVSCPDAGGWRLFVPVKVRHNQAVLVLTRGIATGETLAAADISTAQRDAARIAGAVLSDPASAAGRIARRPLQAGSLLSANDLVTERLIKRGDNVALVSRRGSVEVRIAGRAMGDAGENERVSVENLSSRRIVQGTVDAHGDVIVAR
>NZ_CP018756.1|WP_079221845.1|1769770_1770715_-|chemotaxis-protein-CheV
MSHDLLNRIDQRTRLAGHNRLALLLFRLGGRQLFGVNVFKVQEVLRRPELFQVPGLPGQFAGVADVRGRSVPVLDLGLAIGHPEREPDADTAPGYLVVTEFNRSIQGFLVSGVERIVNIAVEDIHPPPELGAESSYLTAVTRFQGELIQVIDVESVLADIAQIRGEAVLDPTMAMPADAPQLQVLVVDDSRVARQQIRSVLDQLGVGATLLSDGKQALDHLLQIHASGENPADRYAMVISDIEMPAMDGYTLTTEIRRHAGLSGLYVLLHTSLSGVFNNAMVERVGANAFVAKYSPHELADFVLDRLRKVAMAA
>NZ_CP018756.1|WP_079221844.1|1769237_1769633_-|flagellar-basal-body-rod-protein-FlgB
MRNLITDYLGVHAQAMPLREQRMKLIASNLGNADTPGYKAQDLDFDAALRNAQGLDANGLMTTTSERHYEISSGLNPFQVAREGVQPSLDGNTVDPDAERAAYGRAALEYRASLSFVESKVRSMLTAITGQ
>NZ_CP018756.1|WP_079221843.1|1768826_1769234_-|flagellar-basal-body-rod-protein-FlgC
MSNLPIFDIAGSALQAQSVRMSTIASNLSNADSIAGSADAVYKPLEPIFQAVTSKTDPNITSVKVKEITQSDAAPIKRYEPGHPLADADGYIYQPDVDPVAQMVNLISTSRNYQAGVEMLTTAKELALATLTMGR
>NZ_CP018756.1|WP_079221853.1|1780782_1781274_-|hypothetical-protein
MALALIALLLVEVLLLVRWAPFFFGTGIALFNQRIAASPAELAQLSLDGLDHDLPDEKWMRLVFHALPDGSVAFRESYTPHFGGRYFPLLRGQLVVDTRRREVRVIGRCSWFALVFTAMLLPIVLVRPMAWPMVVFLLVFYMGYYIQRRRYAGVGEAVRARLR
>NZ_CP018756.1|WP_079221854.1|1781411_1781759_-|hypothetical-protein
MSTAFMTWLGFVAMIVIAVCFTWRPAYATLRPPRHRPVAFLFGSLVFLLMAFMFAWLPANAIDTGHIHVSHRRAGTLDAWREIEPITFWLIIVAEYLCGLLIASYAIAGIALMDR
>NZ_CP018756.1|WP_079221855.1|1781856_1782072_-|hypothetical-protein
MTLIRALPPIDPNQRPRNPGVREQLQALETVAREEIEELQQLADARPAPSAPAGELLGMAWDLGLDGDALR
>NZ_CP018756.1|WP_079221856.1|1782170_1783361_-|chemotaxis-protein
MYSRIFIRLAAPLALTLLLPFAIGFEWPAALRWAILTTMTLSWLGFAWWTTRAQAHRSPEHARVLREQDQLLTELRNFVGNEIDGSRGEVERARDLIRQAVSSLGGSFDAMNRKSRQQSQALSRIVDRAGDEGSAGLDVARFAQHASHRMEQLVEALEQVSGQSSTTVQHIDQMAQHLDGIFALLEDVKSIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLSERSTTFNEQIRKLAHSSKDAIAKVRETVSHMASRDMDRSREARQEAAAMLDNVAQINASLGDGMREVSECARSIDGSVAEAVRALQFEDIATQALGGVHTHLDRLTAINREAVALQELLHRNGGVFDEEIATALQRTGSRLRELRSEWERPPHKPVAQQNMGAGTVELF
>NZ_CP018756.1|WP_079221857.1|1783534_1784149_-|high-frequency-lysogenization-protein-HflD
MSFTVDDRVLALAGIAQALQQVRRIADTGHSDAAAVRTAVDSVFRIDAASPQEVFGDRDALKSGLRLLHNYFRNQGQDPILPKLALSVLQLERRFVQDGATVNKVASGIERAQRQALELGDSGHPDVLASLGGLYADTISHLKPRVMVQGNPHYLAQAGVVAEIRALLLAAVRAAVLWRQLGGSYWDFLLSRKAMTEAVDRQLA
>NZ_CP018756.1|WP_079221858.1|1784145_1785288_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSSPRVMVGVSGGVDSSVAAWRLVQQGEAVAGLFMQNWADDGSGDCRAEDDRRDAVAVCGLLGIPFHFRDFSNEYWQGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLDAARELGAERIATGHYARIAQRGQQWLLLRGADRSKDQSYFLHQLGQEQLAATLFPIGDLEKSDLRRIARDVSLPTHAKKDSTGICFIGERDFREFLGRYLPAKAGQILDPADGSVIAEHPGVFYFTLGQREGLNIGGVRGRPAAPWYVVGKDVASNVLYVDQDRDSRWMLSDRLRSETAHWIAGAPPARRFECTAQTRYRQPDEPCTVEVLDDGSVLVTFARPQRAVTPGQSLVLYDGDVCLGGAVIAATDAPLEQRLRTTPSPFEVIAA
>NZ_CP018756.1|WP_079221859.1|1785284_1785746_-|NUDIX-hydrolase
MNAVQDPRWAPHATVATVVVDGGRVLLVEETIDGRQVLNQPAGHLEPGESLAAAALRETREETGWTVELSAFIGCYQWTAPDGTAFLRFCYAARPVSHDPAQPLDTGIDRALWLEPAELQAAGPRLRSPLVWQVVADYLAGQRHPLSLVQEVA
>NZ_CP018756.1|WP_079221860.1|1785747_1786236_-|hypothetical-protein
MKRTLLPALLLALAAAGTAGAATTADSSKADAAIARHLEKLGYTFEVDEDGDYQMVFDVEGDRTQMVYVRSAVEDFGSHNIREVWSPGYVSKDKQFPEAVANRLLEDSQDAKMGGWVKQDKTAMFVVKIDADATTDQLSDAIDAAIRTADAMELELTKKDDL
>NZ_CP018756.1|WP_079221861.1|1786346_1786673_+|ATP-dependent-Clp-protease-adapter-ClpS
MPRESSPESHHDHGIAVEPARPEVAPPPFYQVMILNDDYTPMDFVVDVLQQFFSMDLDKATQVMLHVHTRGRGVCGVFTREVAETKVAQVNEYSRMNQHPLLCTMEKA
>NZ_CP018756.1|WP_079221862.1|1787009_1789292_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA
MFSKDLEHTIGQCYKRAREARHEFMTVEHLLLALLDNPSAQAVLKACGADAERLRQELEQAIEASVSRLAEDDGRDTQPTLGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAVYYLNQQDVTRLDVVNYLSHGIAKLGEEGEQPSSPEGESRMEGGDGEPKGDALTEFASNLNEQARAGRIDPLVGRADEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLARRIVEGSVPDVLADAVIYSLDLGALVAGTKYRGDFEKRLKGVLTALKKVPNAVLFIDEIHTIIGAGSASGGTMDASNLIKPALASGELRCIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETYEILQGLKSKYEAHHGVTYSDEALQAAVDLSVKHIADRLLPDKAIDVIDEAGARQRLLPEGQRKELIDVEEVEAIIAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQDPAIGTLASAIKLARSGLGNPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEPHSISRLIGAPPGYVGFDQGGLLTEKIVKTPHCVLLLDEIEKAHPDIFNILLQVMDRGVLTDTNGREANFKNVVLVMTTNAGAAQASRRSIGFTKQDHATDAMETIRRSFTPEFRNRLDAVVQFQPLGFEHILRVVDKFLIELEMLLQEKHVSLSATPTARDWLAHHGFDPLMGARPMARMIQDKIKRPLADELLFGKLVNGGRVSIDVRDDELVVETHAEPERLLPATVE

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Crispr_ID: NZ_CP018756_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_11

1917247-1917376

Orphan

Consensus_repeat	Method
GGCCCTACGGCCCACCAAGGTGGGCATCTACCAAGGCGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_11

>merge|NZ_CP018756|11|1917247-1917376|CRISPRCasFinder
GGCCCTACGGCCCACCAAGGTGGGCATCTACCAAGGCGGTTTCCGGTGACTGGACGGGCTTCGGTAGATGCCAACCTTGGTTGGCCCCCGGCCCTACGGCCCACCAAGGTGGGCATCTACCAGGGCGGTT

>NZ_CP018756|11|11|1917247-1917376|CRISPRCasFinder
GGCCCTACGGCCCACCAAGGTGGGCATCTACCAAGGCGGTT	TCCGGTGACTGGACGGGCTTCGGTAGATGCCAACCTTGGTTGGCCCCC
GGCCCTACGGCCCACCAAGGTGGGCATCTACCAGGGCGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079221957.1\|1910243_1910639_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221964.1\|1917512_1917914_+\|response-regulator	unknown	unknown	gnl\|CDD\|381122
NZ_CP018756.1\|WP_079221967.1\|1918475_1919639_-\|glutathione-dependent-formaldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|176243
NZ_CP018756.1\|WP_079221963.1\|1916484_1917144_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187554
NZ_CP018756.1\|WP_079221968.1\|1919738_1920215_-\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NZ_CP018756.1\|WP_079221955.1\|1908749_1909355_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP018756.1\|WP_079221969.1\|1920293_1921151_-\|excinuclease-Cho	unknown	unknown	gnl\|CDD\|182535
NZ_CP018756.1\|WP_079221959.1\|1913713_1914163_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221958.1\|1910657_1912856_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
NZ_CP018756.1\|WP_079221972.1\|1923280_1924219_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NZ_CP018756.1\|WP_079221960.1\|1914323_1915250_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|376570
NZ_CP018756.1\|WP_079221956.1\|1909455_1910139_+\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
NZ_CP018756.1\|WP_079221965.1\|1917943_1918138_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225231.1\|1922540_1923293_-\|PIG-L-family-deacetylase	unknown	unknown	gnl\|CDD\|225031
NZ_CP018756.1\|WP_079225230.1\|1913060_1913717_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP018756.1\|WP_079221970.1\|1921270_1921960_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133035
NZ_CP018756.1\|WP_079221966.1\|1918154_1918469_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221971.1\|1921956_1922544_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|283141
NZ_CP018756.1\|WP_079221961.1\|1915263_1915701_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079221962.1\|1915733_1916285_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238496

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079221964.1\|1917512_1917914_+\|response-regulator	gnl\|CDD\|381122	cd17586, REC_PFxFATGY, phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators. This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.13019e-19
NZ_CP018756.1\|WP_079221967.1\|1918475_1919639_-\|glutathione-dependent-formaldehyde-dehydrogenase	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NZ_CP018756.1\|WP_079221968.1\|1919738_1920215_-\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	4.10403e-38
NZ_CP018756.1\|WP_079221955.1\|1908749_1909355_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.17057e-17
NZ_CP018756.1\|WP_079221969.1\|1920293_1921151_-\|excinuclease-Cho	gnl\|CDD\|182535	PRK10545, PRK10545, excinuclease Cho.	8.60158e-139
NZ_CP018756.1\|WP_079221963.1\|1916484_1917144_-\|NAD(P)H-binding-protein	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.30464e-49
NZ_CP018756.1\|WP_079221958.1\|1910657_1912856_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	1.58904e-98
NZ_CP018756.1\|WP_079221972.1\|1923280_1924219_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	4.64443e-09
NZ_CP018756.1\|WP_079221960.1\|1914323_1915250_+\|GAF-domain-containing-protein	gnl\|CDD\|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	3.3656e-06
NZ_CP018756.1\|WP_079221956.1\|1909455_1910139_+\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	1.13523e-102
NZ_CP018756.1\|WP_079225230.1\|1913060_1913717_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	0.000449997
NZ_CP018756.1\|WP_079221970.1\|1921270_1921960_-\|glycosyltransferase	gnl\|CDD\|133035	cd04192, GT_2_like_e, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.93547e-14
NZ_CP018756.1\|WP_079221971.1\|1921956_1922544_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|283141	pfam05401, NodS, Nodulation protein S (NodS). This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors.	6.3842e-15
NZ_CP018756.1\|WP_079225231.1\|1922540_1923293_-\|PIG-L-family-deacetylase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	3.48726e-27
NZ_CP018756.1\|WP_079221962.1\|1915733_1916285_-\|cysteine-hydrolase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	5.30592e-45

>NZ_CP018756.1|WP_079221963.1|1916484_1917144_-|NAD(P)H-binding-protein
MSQVFIVGAAGKVGRSLVEQASARGHRVLALHRGQDQAAELTALGAGPVQGDLLQLDVAALAALMKGCDVVVFSAGAGGKGGASMTDAIDGRGLELAVAAAQAAAVPRFLLVSAFPEAGRGKHLSDTFENYMVVKKRADVHLAESPLDWVILRPGTLTDEPGTGRVRAGLAIPYGNIARADVAATLLALIEHPQLRRCIIELTEGETPVFDALQALSPA
>NZ_CP018756.1|WP_079221962.1|1915733_1916285_-|cysteine-hydrolase
MSPSRIPRRGLLVIDMQHGLFNGAHRPYRADEVLVNINALIDRAHAADAPVFAARHVGPAGSPLASDSPLSQLLAGLAIDPARDTVFEKTRPSCFFETGLVERLAAAGVEELVIVGMKTDYCVDTTCRAARDLGVAAVLVADAHTTTDSAVLEAQTIVEHHNATLRGAFVSLVASADCTFAAG
>NZ_CP018756.1|WP_079221961.1|1915263_1915701_-|hypothetical-protein
MGPMTQTRTLRNSLVLMLLSAVTGCSTTAGGDRHPAPQLRAVTLTPEASTVWLTAASIGTIEPIGSCVYFVTGSGQRLLALWPDGFELERKDGVAVGVRYTRTGKGVAFGTTHTFGSGALSALPGSLADPLPADCSGPATMLWFD
>NZ_CP018756.1|WP_079221960.1|1914323_1915250_+|GAF-domain-containing-protein
MTDHSSAAFTETERQHALDALHVVGSLPEPAYDDIVKVAAAVCGTPMALVTLIDRDRQWFKARIGVEGSETDRDVAVCDHAIRQPDQLLEVGDLKQDSRFVDNPVLNEMGARFYAGMPLVTREGAAVGSVCVVDLTPRSLSAEQRDALQALARLTMNLMEARSREREQEVATILEQSPLVDAAHATTGTACTVVILELQDLAALAEQMGERSLERQLQQLDVALEQCLDATRGDSINRVTGSGEFIAVLGSDQASDTLAALQAVADDASSRLARPLLLGAAGGTGEESTSAVFLRADRELSARKDEQR
>NZ_CP018756.1|WP_079221959.1|1913713_1914163_-|hypothetical-protein
MERGHAMVVRPLLLSGWLLAAALPAAAQQIRSATGPAPRPLPAAPRPAHNSMAKSTTPFNCDQYAWPNHPHPGMKAYCASVEAGILQNEARQAGRPGPSAEVGVLPALGSAEAKRTGTACIGGQAFRRLANGWEQISAPAGGWLRCRER
>NZ_CP018756.1|WP_079225230.1|1913060_1913717_+|TetR/AcrR-family-transcriptional-regulator
MKDSEQAPTRGRPKKLSHARIVEAGMAMGLRDLTFVRLAGALGVTHMTLYNHIASLEALKVAVAEAIFERWQMPPVERGDGQALPDYLIDFIASLRDLVIAHPGLTPYLLRRSVASPTMSARIAGHQSEVAAAYALPVEQARWLMSTVAFHCIAVADTLYAGAGKDAVPAGTRARDASEVDREFAQGMHALALGALQILRSGVDLQSLSLPPPAAKSG
>NZ_CP018756.1|WP_079221958.1|1910657_1912856_-|TonB-dependent-siderophore-receptor
MTPDVRCHAPLSCLRAGRATPLLLALGGVLILPAPSVLAQAIAAAADRAPQVSTLDSVNVHERRTVTDPYAGGQVASGGRVGLLGNRDFMDTPFNTISYTEAYIADRQARDITSVIAAADPTVFTNNASGAWSENYAIRGFASSTTDMTVDGLFGMAPFYRTSPEMFERIDVLKGPSALLNGMPPGGSVGGTINLIPKRAADTPLTRLSVDHGADAQFGGHVDVGRRFGNRNQWGVRVNGVHREGEGAIRHQDKAYQLGSLALDWRGERSRASLDLYAAEDLIHGPTRGVSLDVGVAVPKPPRADVLINPEWGRVESRDKGAILRGEVDFNDHLMGYAAFGASETDYSYNGAISALVLNDAGDFRTTVAQLAFNTRKQSADVGVRGSFRTGPVSHQLAANATAYQHKQDDYGRRSVPEASWVTNLYAPTWNEAPPFITPHIMHTEVKLRSVGVADTLGFADDRVQVTLGVRRQQVQSDAFDINTGALSSRYKQSATTPAAAVLFKLGGKVSLYANSIEGLSQGATAPTTAANAGEVFPPFKTRQKELGLKLDAGRFAHSFSLFEIKRPNGYTDPVSNIYSFGGEQRNRGADWSFFGSPLDGVRLMGGVAYVQPKLTRTQSGINEGKLATGLPKVQGKITAEWDLPMLEGLSLNAGITSMSRQFISADNTQWVAGHTVYDLGARYATRLSARPLTLRGTINNLTNTAYWGQPLLSSLALGAPRTFTVSATVDF
>NZ_CP018756.1|WP_079221957.1|1910243_1910639_+|hypothetical-protein
MTRTQATPTAATGTVPPDLFGTLRQMLLRHGDGLLVVHDTDQHFYANCRRPGANGKAQFFAAVKVSGRRHAFHLMPVYDFPELLAGISPALKQHMQGKSCFNFEHWDDALLQQLQALVDQGAARYVAEGRL
>NZ_CP018756.1|WP_079221956.1|1909455_1910139_+|type-1-glutamine-amidotransferase-domain-containing-protein
MKVLIVLTSHDQLGDTGHKTGFWLEELAAPYYAFKDAGAEIVLASPKGGQPPLDPKSNEPAFQTELTHRFEADAAAKAQLAATVRLDSVNAADFDTVFYPGGHGPLWDLANDTHSIALIEAFVASGKPVGLVCHAPGVLRQVKAPDGKPLVAGKQVTGFANTEEDAVGLTNVVPFLVEDMLKDLGGDYSKGPDWGSYVLRDGLLVTGQNPGSSAEAAAVLIQAVAKA
>NZ_CP018756.1|WP_079221955.1|1908749_1909355_+|TetR/AcrR-family-transcriptional-regulator
MNSATDTAGTDVRQKILASGRRTMGGKGFSAVGLNEVLTAAGVPKGSFYHYFGSKEAFGEALLQDYFDEYLAEMDQIFRAGGQTRAQQLDSYFAAWMASQSFEDCQGKCLAVKLGAEVADLSPAMRAALRSGTAGIIQRLARAIEGGQADGSLACSGDAAALAQSLYQLWLGASIMVKIVRGPQPFDNAQRATRQILHPSR
>NZ_CP018756.1|WP_079221964.1|1917512_1917914_+|response-regulator
MQKYGNEQTQEHCLLLVEDQLDLAELVEDALSNEGNTITHAESVFEALSLLRNEQFDAAILDIELGDGVVFPVADRLAELGVPFLFASAVYDQVVPARHQKARFVAKPFHIPQLQEAVNQTLAQSRGRQPLQR
>NZ_CP018756.1|WP_079221965.1|1917943_1918138_+|hypothetical-protein
MSKLPFNPTGDASDQDKAHTPDKVRTDQSWKKGKDMPEQNETAHPDDYERPEVDPTGGRRGSKD
>NZ_CP018756.1|WP_079221966.1|1918154_1918469_-|hypothetical-protein
MSTPPLTPDKRYIVVRGRLWRATNPNLTATERARWVAALMDARRAVQAAMRSGEAAALRNARRAVDAAKRGLGERGPVWWTDGGKDYNRYLVKNTPYASWFDGL
>NZ_CP018756.1|WP_079221967.1|1918475_1919639_-|glutathione-dependent-formaldehyde-dehydrogenase
MQALTYHGRKDVRVETVPDPVLAAEDDIILRVTATAICGSDLHLYRGKIPDLHTGDVLGHEFMGIVEEVGRGVTQVRPGDRVVIPFVIACGECFHCQLAEYAACETTNPGKGAALNAKGLMPPAALFGYSHLYGGVAGGQAEFVRVPKANVGPLRIPDGAADEQVLFLSDILPTGYQAALNAGVKAGSTVAIFGAGPVGLMSAACCRLLGAETIFMVDHLPYRLDFAQRTYGVTPIDFGKVDDPADYIISQTSGRGVDACIEAVGFEAEGSSLETALTAVKLEGSSGVAIRQCIAAARRGGVVSIPGVYAGFIHGFLLGDAFDKGLTFKMGQTHVQGLMPELLTAILEGKLDPGNIISHRMSLAEAAQGYAMFDAKDDDCRKIVLTP
>NZ_CP018756.1|WP_079221968.1|1919738_1920215_-|DUF421-domain-containing-protein
MSDLFELGMPWFEFVLRATAVYVVVLLLTRLSGKRSIGQSAPFDMLVIVLLGTAVQNSLIGEDTSLLGGLILAATLLGLNWLVGFVTARSRRLHRWVEGAPVVLVRNGKVFWEQLRRCNVAPEDLDVAMRKAGCDGHHQIELAMLETSGEITVDAEGR
>NZ_CP018756.1|WP_079221969.1|1920293_1921151_-|excinuclease-Cho
MPSNAQAARRSARAAGYVFPEHLREQAQALPTQPGVYTFHGREGGLPLYIGKSINLRTRVMDHLRTAEEAAMLRQSERISHLPMAGDLGAQLLEAAMVKAERPLYNRLLRRLPRQFSMRLYRGEISVVNSAEVDLTSTPMLYGIYSSARAAREALRRVADENRLCYSLLGLERLPAGRPCFRSMLRQCAGACCGGETLAEHQQRLADALMLLEIAEWPYAGPVAIEERGEAMRQFHVVDGWFYHGSAKTLAAARRVRRTDPLFDRDAYRILRKGLSLGQWALHPL
>NZ_CP018756.1|WP_079221970.1|1921270_1921960_-|glycosyltransferase
MIGVLVPAHNEAEHLPACLRSLAIAAAHPGLAGEPVQIIVALDACTDGSAEVCAGMAAEILSLQARCVGAARAAAAGVLVERGATWLASTDADSEVPADWLVAQRGAGTDVFCGVVDLGELAPQQAWLRSCFQRSERWGEGHGRVHGANMGVSAAAYQRAGGFAAKRCSEDVDLVQRLEDAGASVRWAAAPVVTTSSRLSGRATGGFADHLARLAALQASPHPEFALAY
>NZ_CP018756.1|WP_079221971.1|1921956_1922544_-|methyltransferase-domain-containing-protein
MSAQPYFDEIHANEDPFGYRTRWYEERKRDLLMASLTRPGFQRGWELGCSNGVLTERLAGRCERLLATDISPRAAFQARRGLAHLPHVQVHCAQHPQQWPAGRFDLIVCGEMGYYLGPDALVELRDGLHAAMKDDGLLVACHWLPSFPGRATRSALVHERLGHGLQEAFCYRDSDFILQGWTRAPLSLASNEGLR
>NZ_CP018756.1|WP_079225231.1|1922540_1923293_-|PIG-L-family-deacetylase
MGAVATIHGQGSDERAWEHCDWLWQQPETPLAELVAGAGRIVVVAPHPDDEVLACGGLLCAAAAIGVPVQVVAVTDGEACYPGEAWWTPQRLRQARREELRDALGELAIDAASIVHLGIADGGVSNHETGLEDWLWQTLREDDLVLAPWRFDGHPDHEAAGRAAWRAARSAGCQRLEYPVWGWHWLDPGCAHMAWEAPRLLDISAVAARKREAIAQFRTQTGNVPRLQAEPILPAHVLTRFYRTHEVYFA
>NZ_CP018756.1|WP_079221972.1|1923280_1924219_-|acyl-CoA-dehydrogenase
MLAPVLPPPLSNLARQRLLQVPGLPLPGQGHTLERWRALAALGHEDLCLAKVLEAHHDAVAILHELRVPVPAEQLLAVWAAEGPASTLRAEHTGRLRGDKPWCSGSNLADTALVTVRGESGVQLYKVDASQWHCMESEPWPAAGMAGVPSTTVRFDDAEAEAVGPVNGYLERPGFWHGGAGIAAVWFGAATALAERMQHACSEGLRARLLGKADLALAPAAALLRELAHAIDAAPQLTHRVQVVRVRSVVERAATQVLDLAGRALGPAPMCMEDAHARRWADLTVFMRQSHADKDWEWLGGQCARQVMPWAL

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Crispr_ID: NZ_CP018756_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_12

2176933-2177065

Orphan

Consensus_repeat	Method
AGATGTGTCGACCAACGGTCGACACCTACCAACAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_12

>merge|NZ_CP018756|12|2176933-2177065|CRISPRCasFinder
AGATGTGTCGACCAACGGTCGACACCTACCAACAGCCTGTCGGAGTCGTCCCAGTAGAGCCACGCCATGCGTGGATGAATTCATTCGATATCTGACAGATGTGTCGACCAACAGTCGACACCTACCAACAGCC

>NZ_CP018756|12|12|2176933-2177065|CRISPRCasFinder
AGATGTGTCGACCAACGGTCGACACCTACCAACAGCC	TGTCGGAGTCGTCCCAGTAGAGCCACGCCATGCGTGGATGAATTCATTCGATATCTGAC
AGATGTGTCGACCAACAGTCGACACCTACCAACAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222178.1\|2171249_2172443_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP018756.1\|WP_079222179.1\|2172537_2173467_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP018756.1\|WP_152027087.1\|2187608_2188169_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222186.1\|2180182_2180794_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP018756.1\|WP_152027085.1\|2179294_2179939_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222184.1\|2178615_2179257_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_159095277.1\|2181615_2183310_-\|DUF2235-domain-containing-protein	unknown	unknown	gnl\|CDD\|370774
NZ_CP018756.1\|WP_079222175.1\|2166148_2166481_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222180.1\|2173479_2174937_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP018756.1\|WP_079222174.1\|2165635_2166070_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP018756.1\|WP_079222176.1\|2166580_2169607_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP018756.1\|WP_079222187.1\|2180790_2181576_-\|CDP-diacylglycerol-diphosphatase	unknown	unknown	gnl\|CDD\|235485
NZ_CP018756.1\|WP_079222183.1\|2177269_2178430_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|180337
NZ_CP018756.1\|WP_079222182.1\|2175782_2176664_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237907
NZ_CP018756.1\|WP_079222177.1\|2169599_2170253_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP018756.1\|WP_161490378.1\|2183813_2184677_-\|DUF4123-domain-containing-protein	unknown	unknown	gnl\|CDD\|379225
NZ_CP018756.1\|WP_079225254.1\|2184673_2187454_-\|type-VI-secretion-system-tip-protein-VgrG	unknown	unknown	gnl\|CDD\|226032
NZ_CP018756.1\|WP_079222181.1\|2174990_2175689_-\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|223738
NZ_CP018756.1\|WP_161490377.1\|2183296_2183794_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371700
NZ_CP018756.1\|WP_079222173.1\|2164982_2165639_-\|hydrolase	unknown	unknown	gnl\|CDD\|238494

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222178.1\|2171249_2172443_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.73768e-48
NZ_CP018756.1\|WP_079222179.1\|2172537_2173467_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.37166e-60
NZ_CP018756.1\|WP_079222186.1\|2180182_2180794_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.9248e-06
NZ_CP018756.1\|WP_159095277.1\|2181615_2183310_-\|DUF2235-domain-containing-protein	gnl\|CDD\|370774	pfam09994, DUF2235, Uncharacterized alpha/beta hydrolase domain (DUF2235). This domain, found in various hypothetical bacterial proteins, has no known function.	3.26758e-21
NZ_CP018756.1\|WP_079222180.1\|2173479_2174937_-\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	1.70133e-34
NZ_CP018756.1\|WP_079222174.1\|2165635_2166070_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.66247e-27
NZ_CP018756.1\|WP_079222176.1\|2166580_2169607_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.78269e-38
NZ_CP018756.1\|WP_079222187.1\|2180790_2181576_-\|CDP-diacylglycerol-diphosphatase	gnl\|CDD\|235485	PRK05471, PRK05471, CDP-diacylglycerol pyrophosphatase; Provisional.	1.02722e-90
NZ_CP018756.1\|WP_079222183.1\|2177269_2178430_-\|amidohydrolase-family-protein	gnl\|CDD\|180337	PRK05985, PRK05985, cytosine deaminase; Provisional.	0
NZ_CP018756.1\|WP_079222182.1\|2175782_2176664_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|237907	PRK15092, PRK15092, DNA-binding transcriptional repressor LrhA; Provisional.	8.49293e-47
NZ_CP018756.1\|WP_079222177.1\|2169599_2170253_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.32143e-67
NZ_CP018756.1\|WP_161490378.1\|2183813_2184677_-\|DUF4123-domain-containing-protein	gnl\|CDD\|379225	pfam13503, DUF4123, Domain of unknown function (DUF4123). This presumed domain is functionally uncharacterized. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important. This domain is sometimes associated with the FHA domain.	9.48489e-12
NZ_CP018756.1\|WP_079225254.1\|2184673_2187454_-\|type-VI-secretion-system-tip-protein-VgrG	gnl\|CDD\|226032	COG3501, VgrG, Uncharacterized protein conserved in bacteria [Function unknown].	6.2853e-100
NZ_CP018756.1\|WP_079222181.1\|2174990_2175689_-\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|223738	COG0666, Arp, FOG: Ankyrin repeat [General function prediction only].	3.58192e-18
NZ_CP018756.1\|WP_161490377.1\|2183296_2183794_-\|hypothetical-protein	gnl\|CDD\|371700	pfam11745, DUF3304, Protein of unknown function (DUF3304). This is a family of bacterial proteins of unknown function.	0.0069105
NZ_CP018756.1\|WP_079222173.1\|2164982_2165639_-\|hydrolase	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	6.54495e-66

>NZ_CP018756.1|WP_079222182.1|2175782_2176664_+|LysR-family-transcriptional-regulator
MQDSAKSNRTLFELDLLRALVMVADCGSFTTAATRLHSTQSTVSQKVRRLEELAGHRLLERGHRDVHPTDAGHTLLGYARRMLDLNEEMAQALAGATVETAVRIGVPEDFVNAQTTRMLAAFSRRHPQVKLEISSGLSRDLAHGFDHGELDLVLVKQRRNTRQAVHCRREPMHWIDSLRSSSLLQDPLPLVTFPPRGLYRDEMIQAVEALGLRWRIAFTSSSLSGIQGAVADGIGISLLPRRAVGREHRVIDGERGLPVVDNYEIGLLHRPDADDAVRALAAELWRQVQREAE
>NZ_CP018756.1|WP_079222181.1|2174990_2175689_-|ankyrin-repeat-domain-containing-protein
MRIHRCRRWPRPLGRLLLLCLLAVVVPACSATAGPADVRLRDAATRGDADAVRAALEDGADLESRDGQGRTALLLATHGNNVDAARELIEAGADVNAKDAMQDSAYLYAGARGLDDILALTLAHGADLRSTNRYGGTALIPAAERGHVATVRTLLRAGVAVDHVNRLHWTALLEAILLGDGGPRHVQIVQLLLDAGANPELADGDGVTPLAHARQRGYTQMETLLRRAGARR
>NZ_CP018756.1|WP_079222180.1|2173479_2174937_-|amidohydrolase-family-protein
MFRSRPLSLAILLAVAPLSVSAAERADLLIRNATVVDVEHARSVPGQSVVIRGDDIVAVGPDAQLRSQWTASRQVDAKGKYLIPGLWDMHVHFGGGPALIEENKALLPLYIAHGITTVRDCSGDLPEQVLQWRGEIANGTLFGPRLLTSGAKIEGIKPVWKGTIEVGSEADADKAIARLQHDKVDFVKITDSTLKPELFLYSASAARKAGLKASGHIPMALTVEQAVDAGLASIEHLDYAFKAGSKDEAQIAADFGAGRIDRAEANRRLDASFDHDTAMHAYRDFARRGVFVTPTLNGGRILDFLDQDDHANDPYLAYIGPGLRATYQWRVDRAAKASPAQIEARHAQYHQVASVLPLLQEAGVTIIAGTDAGFLNSYNFPGIALHQELQLFVKEGLSAPQALSAATRSGPAWFGQMDRYGGVATGKAADLVLLTANPLQDIAATEKIDSVILRGTVYDRAALDKMLADTKAKVAAWNAEAAKQE
>NZ_CP018756.1|WP_079222179.1|2172537_2173467_+|LysR-family-transcriptional-regulator
MNDLPAGADRLDLLRTFLRIVDAGSLSAAATQLGTTQPTVSRRLQALERQLGLRLLQRSTHGLQLTEDGQRCQRHAQRVIDEWEALQAELHGEAQVLRGRLRVMVPHAFGQAQLLPTMLDFLARHPQLSLEWILEDHRPDFVADGIDCAVRVGPVDEPRMVALPLAEVPRIVVAAPTLADPSHIRTPEQAQALPWIALATYYRERLLLHDAQGRAHTLSIAPRLLTDNLFVVQRAAVAGLGAAVVSAWLVAEDLAEGRLVQLLPQWQAPPLPVHLVFPAARQQPLRLRAFIDAMKEALPQLHGMRPAAR
>NZ_CP018756.1|WP_079222178.1|2171249_2172443_-|MFS-transporter
MSTPSVSVTATPTAAPSAPLVLAMAAGAGFSVASLYYSQPMLGLIAQDLGASERGVGLVPTLTQLGYALGILLLAPLGDRFDRRHLILLKSVLLSVALAAAAWAGQLPGLLVASLLVGLMATLAQDIVPAAAVLAPDAHRGQIVGRVMTGLLLGILLSRVVSGVVAEAWGWRTQFVLAAVSVAAMGAVMAKALPRFAPTSTLHYPALLGSLLQLWREQPQLRRAVASQSLLAVGFSAFWSTLALMLHATLGLGSAAAGAFGIAGAAGALAAPFAGRYADRLGSHAVARLAIAVALVGFGLLLADSWLPAAALLPLLVVSALLFDFGFQSALVAHQTLVYGLVPPARSRLNALLFTGMFIGMAAGGALGSLALAQWGWHGVAWLAVVCAGSSLLVRLR
>NZ_CP018756.1|WP_079222177.1|2169599_2170253_+|response-regulator-transcription-factor
MTESSSPIGVLVVDDHPLLRDGLAALLGAQPDLRLLGEAADGEEAIARYQELQPDVVLMDLQMPRLDGVEAIVRIRALDPRARIIVLTTYRGDVRAVRALQAGASAYLLKDMLRHELVDTIRTVAGGRRAAIPPSVAASIAAHVVEDRLSPRETEVLRHVAGGLSNKRIGERMQISEQTVKAHMKSLMDKLGVGDRTHAVTQALRRGIISLDDTGHD
>NZ_CP018756.1|WP_079222176.1|2166580_2169607_+|histidine-kinase
MLPMRGRPFPFLRRLPALLTCLLLIALPAFAEQRPVVANGMPGYQHTAWRVGQGAPGDIWDIAQDHQGMLWLATGSGLYRFDGRRFERQSAPAGSAFPSTNMVSLAVDPDDSLWIGYFQAGISQLSPAHLRSFGRGQGVPTGVVPHFSRDRDGHLWAAINGGLRWFDGLHWRALPVGSGVPERRVQWLLHDRHGTFWVLADLKVWRRPAGASTFEDTGIAVSQMASLAESPRGEIWLADRNRGTSPLANAQGLLPAAEREARRLPELVAARLQFTADGALWATMSPHGGVARVTFEGDQATHMERFDTPQGLTATSAVPVLLDREGNLWVGTNLGLNRFRARSVQALAAGPTDPYRSLVRASDGRVYGYGEDLKPYDLRRSLLGERAAQLQQAARQAPTPLWQFDWINLVRTVNGHATRIPSPAPYTGQSLQAVLFPNDEEAWACVGERGVLHYQHAQWYRQARLPEQACSTMAMGSDGALLLGYADGRLRRMDASGVATFDARQGLAVGPVTALLQDQDMLLVAGEAGLAARIGEAPFSEVRTDMAGVLEGITGMVADAHGRLWLNGSRGLVRLDRTALRDAVRSHQPVAPRLFDAVDGMPGIALQSGPIPTAVQAADGLLWLATNQGLAWLDTNAAHRNTLAPGVRIGDVLYGATQAPLQEGLRLPAGTTQLQIDYVALSLARPERNRYRYRLTGVDEGWQDAGSSTRAYYTNLAPGSYRFDVEAANEDGVWSTAPASRTFSIAATFVQTVWFKLLCAALVLAALVVAVRIRSGQLAALFRARLQERHGERERIARDLHDTLLQGSQGLILRLHAISQSAQTPDSVRTQLESAMQLAERNLAEGRERVNALRDGPFAGRDLATALADVHAEYAGQGTNPLRLTVEGTPPPLQPDAVEEVFLIGREAIRNALRHAEASAIEVELSYGSRCFLLHVRDDGVGIADDDAGHGHWGLQGMRERAQRLGAELQLWTRPGLGTEVALAVPARRLYHRRPPRWRWPWSRKRDD
>NZ_CP018756.1|WP_079222175.1|2166148_2166481_-|hypothetical-protein
MQRLFVMFPDRGPGLGLLWLRLCLAGALCAPGLHDGGLVVLCALGVALLLLGWLTPLSAGLACAGLWLQGAALPLLALPLALLLLGPGAYSLDARQFGRRRLGRRPPPNG
>NZ_CP018756.1|WP_079222174.1|2165635_2166070_-|helix-turn-helix-transcriptional-regulator
MAEATPPVVLAAALAPHQAAALQRALHYIDAHLSQPLRVTELAEVACVSRFHLVRLFRTGTGASPLRYLRRRRIERARQLLPAADQPMSRLAQHLGFFDQSHFVRSFRAETGCSPGQYLAGDAALHLPAVHPSSVAPPTTGTHP
>NZ_CP018756.1|WP_079222173.1|2164982_2165639_-|hydrolase
MTTATATPAKGLLSPTDHALVLIDFQSQMAFATHTIDISALRNNVSLISKGAKGFNVPVVLTTVAEQSFSGPMFPELPQIFPGQAVFDRTSMNTWEDQPVIDEINRIGKQRLVLAGLWTSVCIVGPTLSALEQGFEVYVITDACGDVSDEAHERAITRMVQAGARPITSVQYLLELQRDWARGETYGLTTGIARDHAGGYGIGIQYAKTMFGAQEGGH
>NZ_CP018756.1|WP_079222183.1|2177269_2178430_-|amidohydrolase-family-protein
MTLQFVQGGVDRDGAPVHFHIRDGRFEGLNRAAAPAEGARIIDLKGFTLLPGLVDGHIHLDKSFVGDRWHPHQPVASLRERLAVEKAAVAGAAPMVDRAEALIRQCSRFGTVAMRCHVDIDASTGLRHLQAVREAAQRCADIMQIQLVAFPQAGVMSCAGTAAVLEQALAEGVEVLGGIDPTTLDGDAEGQLALLFGLAERYGVRLDIHLHEPGETGLAQLLRIAARTRAAGLQGRVAVSHAYALGEVPLARALQVGEALAAAGVAIMSNAPGDHPFPPLRALHDAGVRVFAGNDNIRDCWWPYGNGDLLQRAMLLGYRSGFYTDADLMLALEMVTTHAAAVIGLPEHGMGEGMPATFVAVRADHGPAAVAGVPAERRVVVGGRWV
>NZ_CP018756.1|WP_079222184.1|2178615_2179257_+|hypothetical-protein
MGPSDRHDRLRRWQAASLLAAAPIASLSAADAGATAPLQAPPGQQRVAPSALVELLHQRVLAGPSATGTLESWCAEHGLAEQARVRAVRVHGQDKAAPADVLKALGAGAGTPLRYRRVQLVCGNRVLSEADNWYLPDRLSTAMNQVLDSSDEPFGRVVGPLGFQRQTLADQTFWPPRGEGDHGVILEVRALLRDRQQQPFSYVIESYSVQALP
>NZ_CP018756.1|WP_152027085.1|2179294_2179939_-|hypothetical-protein
MAGLLLAMLPGCNRDDAGTTNRAAASGPGERATATEQAAGDVVLPDDAARTPAAAPAPMVAPVPPAAPVQRVAASNQDYLAGESRLLSGNALSMAEAETVLRSRAGFETALQQFEQDAARHQDAQDLSTLYRAAATRALGGDVALASLSCGYSLCMGEIRSRSDTGFRDWVRAFGKDGDAPHYALITAEYVLGKEQSVGRFVFSIDPAANGISQ
>NZ_CP018756.1|WP_079222186.1|2180182_2180794_+|GNAT-family-N-acetyltransferase
MCIEPNSASQLALHPVLRRHLLHLGHGSINLRSLQRTDLAGWRTLCGQRRGGCHLACRTDAEVQLFIGIQRSRLQEDNDRLLLGVFDQASHALVDQITVRLQSARGRSAELQRFCQADWGDAQRFAHTLHALCPFLFEQVGLHRVYVMLPPDDRAGLSDVLRAAGFQKEGLLRDHHLGADGWEDRSLHALTASTWRPQQAAMG
>NZ_CP018756.1|WP_079222187.1|2180790_2181576_-|CDP-diacylglycerol-diphosphatase
MSVVPRLLPLFLSLSVLAGCASTPAPPAHSDALWRLIERDCRSAQGPQGSCLQMEEAADRRDVLVKDSHGDFQFLLMPLDKVSGIESPGLYRKGVPNYFAAAWRARSHTQQALAQPLPREVASLALNSPHGRSQHQLHIHVDCLRADVVQALDAQQAALGMRWAPLPVLLRGHQYQARLLAGAELTANPLNLLAFDLSGPADVGNWSLLVAGHRDVHGAPGFVLLATRLDSATGNDASAEELQDHACSVLTGAGSALERVR
>NZ_CP018756.1|WP_159095277.1|2181615_2183310_-|DUF2235-domain-containing-protein
MTSTDPTAIPGQVDLEPGTPDPVAQAEGTARTARLARGTRPLSDAERRRRQEAMCGTVPDKEAATTGCTQSLHLSVFFDGTGNNREEELGKDAGERALSNIARLYDAHVNDRRNSKRQYLAGVGTPCPEVGDSGGLLGLSIGKGGRERIDFALQALDELIDTQPEPMRILVVSVSVLGFSRGAASARAFARDLAARCKCQADGTWLYRERIPLRIGFMGVFDTVCSVWPNLAAAGINYRNGHTGWAEGMVVPEIVEQSVHMTAAHELRGQFPLDSTREHAVYPANTVEIWFPGVHSDVGGGYDPQHQGRQNSIARFALNEMYDMAQAGGVLLNPISLLEDHVKAEFDKQDPELQAVFNAYLQAVRVKRGRMEDVQAAHMQLLYRWMRVRVARGDQLPSMQRLAAREEALREQVRTLRRRQSQLPAPWDNDNLHLADQGNADKTAEWNRVSDELKVRDDELSAVRKQRRGLEKENDTMVGKIVGLRRRRERGASLTMAERVTLESWDDTTLLPPEVETFFDGYGHDSVAHWFIGNLSQWRVLYFGATKYTPGKVEEAEVEAAVPG
>NZ_CP018756.1|WP_161490377.1|2183296_2183794_-|hypothetical-protein
MSNKYLWWSALAVIALLVVGVGCSRAMARGKTPIMSLFAFNYSPYYLADVRVDGQFLGGLDGYTNGGSGMGPRAPRGKGPDSVQVRWIEANRYDLATNRYLSEGHRVPREAVVPLKTPYPPNPATLLLHFYADGHVEAELLDKGVNKWDVRRMPVPKEHKDHDQY
>NZ_CP018756.1|WP_161490378.1|2183813_2184677_-|DUF4123-domain-containing-protein
MIPDWHFPPIDLPPLEEGLQRFVLLDGAQCNQPVQLLRTLPWAPLPLFDGLLADGADDASVFLARLPRGFEHDRFLQRAASQGRSPGMLSIIETSLDAQQLQQRLQRRLDASYPNGKLFLARFFDARVLPWWVQVLDEAQCRGFLAMGERWWYLRHDLQWAHLELEDVALDPHDPPWVLGAPQRRALIDASYPYTLIDHFQLTDPELLARLPRARWYTFFRRVVATAAAAGIEDSRRVVMVATWALLAGSDLGEDPAWQQRLQDFASGRRSAADIGDEVWPLEESWD
>NZ_CP018756.1|WP_079225254.1|2184673_2187454_-|type-VI-secretion-system-tip-protein-VgrG
MEAMRNLMVQAAGLDAGSRLFRLDLPDLPAVVVDAWQGHDALSTGRHLQVDVLSLDAALPLADWLGQPASLYVRQADGQDWPRHGVIAAAQCLQADGGLVRYRITLRDWTWWLDQAVCSRVFQDQDVRAIVDAVLQTHAPHAHWRWSDDVDALLAASRPRSFCVQYRESDLAFVQRLLAEEGVGWCVEEVADAPAGHGVLLFADSTLLPESAASQARGGIRFHRADATEDDDGVQQLGQQRRLQSTRVQLHSSDYRSVSSLTGQLPLEGAGEGLREDYDAVGAYAFADAAELQHHARLMAEAREAQALQWQGRGSVRSADAGHAWALTGLPGDLPAELLLVEVTHAGVNNLPVDLRECVQVLLGEAAEPDPLQDAAKRHGYVNAFSAVARDRRWRPVLEDGTGARRNARPLAPGYQTAIVVAGASASNDLHADALGRIRVRFHFQGDDGGADSAWLRVAQRYAGPGVGSQFLPRIGQEVLVGFLEGDIDRPVVLGTLYNGRGEAGVAPTTAGASAEDDLSAYGQAADARNSAQANLSGGQAPAWHAAGSGDQAHRHGGALWGIRSREWEGGEGSNHLLFDDSNQQLRTQLASSQQVSQLTLGHLRHQADNYVGSLRGQGFELRSDAWGAVRGTAGAWFSAYVHAGASPAGEAAQPAALLQQLVALAKSYSVAAGTHRTVLPAAEAGVQSTHRSRLDGAQSPLPVLLASVRSTVPAEALAEASAAASQRSSGAGEGVVPHTGDAVLGLSSPAGAVMVAGQGLHWGQGETLVLGSGQHSDAVVMGDARWHGRQAIGVLAAAATGADTQAPTLTLASGEAVLDFKAQQDQVDVQSRQALRAASAQASVEVAAGRTVQVATSGGASITISAGNIVVNAPGRIAVHAGRKSFLPGGSGRYPLPVFPQSVCKECLLLAAQRAAPLTPKGGPA
>NZ_CP018756.1|WP_152027087.1|2187608_2188169_-|hypothetical-protein
MLTGLLPAIAACTGTQGPSDRATMAATADEAALANEDPAAPVGNARYAGTRMLSPHSGCSFLSSPVNFCDDRHRALIERVIAERQPNFNGRYIVAELDEWPEFFQRSVVVINASTGIVYPLPIDALSGPLSAHGRSATYGTVETSLDATQFCLVGAVLAYRSINDGRFCFGFDGGRFTGHVTPYMQ

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Crispr_ID: NZ_CP018756_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_13

2394201-2394303

Orphan

Consensus_repeat	Method
GGCCGGGTGGTGCCCGGCCGTGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_13

>merge|NZ_CP018756|13|2394201-2394303|CRISPRCasFinder
GGCCGGGTGGTGCCCGGCCGTGCGAAGGTTCATCCACGCATGGCGCGGCACTGCATCCACGCATGGCGTGGATCTACTGGGCCGGGTGGTGCCCGGCCGTGTG

>NZ_CP018756|13|13|2394201-2394303|CRISPRCasFinder
GGCCGGGTGGTGCCCGGCCGTGCG	AAGGTTCATCCACGCATGGCGCGGCACTGCATCCACGCATGGCGTGGATCTACTG
GGCCGGGTGGTGCCCGGCCGTGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222375.1\|2404067_2405480_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP018756.1\|WP_079222360.1\|2389773_2390319_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|372545
NZ_CP018756.1\|WP_079222369.1\|2397740_2400203_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP018756.1\|WP_079222363.1\|2392454_2392922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222356.1\|2385756_2387865_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP018756.1\|WP_079222368.1\|2397214_2397541_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222364.1\|2392937_2393741_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|239945
NZ_CP018756.1\|WP_079222374.1\|2402810_2403986_-\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_CP018756.1\|WP_079222370.1\|2400336_2400666_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222362.1\|2391578_2392445_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
NZ_CP018756.1\|WP_079222373.1\|2402405_2402798_+\|DUF3037-domain-containing-protein	unknown	unknown	gnl\|CDD\|378608
NZ_CP018756.1\|WP_079222366.1\|2394329_2396717_-\|GH92-family-glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|377950
NZ_CP018756.1\|WP_079222361.1\|2390331_2391453_-\|agmatine-deiminase-family-protein	unknown	unknown	gnl\|CDD\|377332
NZ_CP018756.1\|WP_079222359.1\|2389122_2389704_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP018756.1\|WP_079222357.1\|2387918_2388701_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP018756.1\|WP_079222372.1\|2401651_2402428_+\|aminotransferase-class-I-and-II	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222365.1\|2393737_2394157_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222367.1\|2396854_2397196_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273980
NZ_CP018756.1\|WP_079222358.1\|2388697_2389078_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NZ_CP018756.1\|WP_152027098.1\|2400943_2401558_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222360.1\|2389773_2390319_+\|thioesterase-family-protein	gnl\|CDD\|372545	pfam13279, 4HBT_2, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	6.93851e-22
NZ_CP018756.1\|WP_079222369.1\|2397740_2400203_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.60037e-63
NZ_CP018756.1\|WP_079222356.1\|2385756_2387865_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.74853e-34
NZ_CP018756.1\|WP_079222364.1\|2392937_2393741_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|239945	cd04501, SGNH_hydrolase_like_4, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	1.46274e-77
NZ_CP018756.1\|WP_079222374.1\|2402810_2403986_-\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	5.59357e-15
NZ_CP018756.1\|WP_079222362.1\|2391578_2392445_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	5.23227e-65
NZ_CP018756.1\|WP_079222366.1\|2394329_2396717_-\|GH92-family-glycosyl-hydrolase	gnl\|CDD\|377950	pfam07971, Glyco_hydro_92, Glycosyl hydrolase family 92. Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation.	0
NZ_CP018756.1\|WP_079222361.1\|2390331_2391453_-\|agmatine-deiminase-family-protein	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	1.57259e-140
NZ_CP018756.1\|WP_079222359.1\|2389122_2389704_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.64925e-07
NZ_CP018756.1\|WP_079222357.1\|2387918_2388701_-\|hypothetical-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	0.000229411
NZ_CP018756.1\|WP_079222373.1\|2402405_2402798_+\|DUF3037-domain-containing-protein	gnl\|CDD\|378608	pfam11236, DUF3037, Protein of unknown function (DUF3037). This bacterial family of proteins has no known function.	5.03353e-52
NZ_CP018756.1\|WP_079222375.1\|2404067_2405480_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.00633e-67
NZ_CP018756.1\|WP_079222367.1\|2396854_2397196_-\|hypothetical-protein	gnl\|CDD\|273980	TIGR02120, Putative_general_secretion_pathway_protein_F, type II secretion system protein F. This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking].	0.00080182
NZ_CP018756.1\|WP_079222358.1\|2388697_2389078_-\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.4723e-44

>NZ_CP018756.1|WP_079222365.1|2393737_2394157_-|hypothetical-protein
MEIPQDVYEHVLGVAVEMANASTHGDTRSQWRLHDELRQYCDAMAVEGRDHPFLWETLGDFTSDSGVAIGYYERALKQARQLGVIEGEASICLELARRHIDQGEKERGYEFALRADEAARQTDDLDLRREISQFLLENS
>NZ_CP018756.1|WP_079222364.1|2392937_2393741_-|SGNH/GDSL-hydrolase-family-protein
MSYILHARCCAAALTLAMTASCVQAQPPQAINPLLVKPVDQVTADEVRYLQQRLSDWPELARYREANARVPAKQAGVPRVLFYGDSITQGWGEKDPAAFFPGKGYLNRGIGGQTTPQMLLRFRQDVIALQPDVVLILAGTNDIAGNTGPSTQAMIEDNLHAMVELARAHGIAVVLASVLPVSEYPWMPGIEPAPKVRALNAALKQYAEAQGLVYLDYYTAMANAAGGLDPVLAADGVHPTAKGYAVMAPLAERAIERALGATPPGAR
>NZ_CP018756.1|WP_079222363.1|2392454_2392922_-|hypothetical-protein
MAAVSNRLVETVARAVFKRNPVLVTELYSSAGGQPRRYASAEALCEHGRALQWVSGGMLLIGVQYADMGGAVRVRPFDTGRGESARFTVSGWGLISILLPMAVDANCAAKVHALTERAALGRERGALDVPPVCDWNWNVVESHKRRLKDVLRKAL
>NZ_CP018756.1|WP_079222362.1|2391578_2392445_+|LysR-family-transcriptional-regulator
MLKHWPPLTALRGFEAAARLGSFHRAAEELHLSQSAISQQIRGLEDYLEQPLFFRQGRSVSLTDAGTDLLATTQAMLRQLAGGIRRLDQYRKPHQLIVSASPAFARHWLVPRLGDFRRRHPGADLWLLTSETPPDMASQTVDIALGDDLQPQPQCQHHVLLQDRLYPACHPSVMAQPATERTTLHGEREWDWSQWQVQGGADVGQQRAGLNFSEPGQLLDAACQGLGIALVSELLAASACAQGLLQPLHAYRVDGPQWSWLLHDDSARDPLVLSFCEWVLALLTPGDD
>NZ_CP018756.1|WP_079222361.1|2390331_2391453_-|agmatine-deiminase-family-protein
MSTRRHFLSQLAGAAGLGGLAALGLGATGTVRAAVPAGWHMPDEHGPQERVFLAFAAQPRVWGAQAAAVNDAVARLARTIARYQPVSLLCRPAQRRQAQDRCGHDNIEFLEVPLDDIWVRDYGGCFVTDGRGGLGLVDLNFNGWGCKQSARNDGAVAPWLAQATGATLLESDLVGEGGGIEVDGQGTAILTESCWVNRNRNPGWSRADIEAELKHHFGLRKVIWLPGIAGEDITDAHVDFYARFVRPGVVIANLDNDPDSYDHGLTREHLRILRAATDADGRRLQVHTLPPPLGGRSNVHTRDNDDLARGYINYLPVNGAVIAPQFGDARADGYCRDLLQGLYPGRVIEQVDIDAIAGGGGGIHCVTKNMPRA
>NZ_CP018756.1|WP_079222360.1|2389773_2390319_+|thioesterase-family-protein
MNLWFRLLHLLLCSLFRPKLQAPFGVSRLPFRVLPNDLDSNLHMTNGRYWNIFDLGRLDLILRMGLGKVALREKWAPIVGAGTIQFRRELKPFQRFTLETRLAGWVGTRIIMEQRVLVGPEQKVVTRALLVTGIYDRRARSFVGMERMMAAIGCDTPPSPPLSAAAEALLAADAALKRDDD
>NZ_CP018756.1|WP_079222359.1|2389122_2389704_-|TetR/AcrR-family-transcriptional-regulator
MSPRASEAPQRVIDAAAQMLARVGLNATSIREVTKLAEAPLGSTYHHFPGGKQELLARATHMAGDKVEALLVELLRDGAVQGLQQFLAMWRERLLRSQFRAGCPVLAAAVEEPVDAVASQPRAAAAEVFVRWQGHLAQAFVADGHAPGQAAGLASLVIASVEGAVAMSRALQDIAPFDQVAAQLLTAAAPPAR
>NZ_CP018756.1|WP_079222358.1|2388697_2389078_-|VOC-family-protein
MLHHLSLGVRDLDAAGRFYDAVLAALGYRRVFEDDTAIGYGVADDEDALCLKLRDDATPPGPGFHLAFAADSAMAVDVFHAAAMATGGRDNGPPGLRPDYGDTYYAAFVVDPDGHHIEAVTKALPA
>NZ_CP018756.1|WP_079222357.1|2387918_2388701_-|hypothetical-protein
MKRTRRFGGSALKLPMTRSSEVARARRQLQHQGWPRLQMALIVLLTGGAGFLASHVLRLAGLDSMLLRYPLAVLLAYAVFLLLMWIWIRWRWDAVADGAGEVASNGGGGGSTPRSGPSWGGNGGHSGGGGASASWGEASAASVMDSDGASLIDAATEHEAGLPLLAVLGILALVASVLLASAWVVWSAPVLMAELLVDAAIVGGLYRRMQGMGAQGWWRLCLSHTFWPLLGLLVFFAALGWGAQQLAPGAVSLMQVVQAL
>NZ_CP018756.1|WP_079222356.1|2385756_2387865_+|TonB-dependent-receptor
MSLPSYRPTPSLLFLAVSLSLAATAHAAPQATTLDAVQVTAADASAQAREALKRVSGASNVIDVAKADSRLSSSADVLAFQPGISAQSPGNEGTKVSIRGSGINRGPGAHASGIAVSLDGLPLTGPGGTPYELLEPLWLSRVEVLRGANGFERGALALGGAIDYVSRSGRDSAGVQLHYEAGSRGYQKRGISWGGVSGDVDYFLAYTDSEFDGYQRHARGDGKGAMANIGWQVTPDLQTRFFVRYRETNHETPGRLTREQIRNDPRAANPANLAIDARRPQPGSTWIGNMTTLQIDEDSSLQAGLVYHTYPMDLGESLYRQQLDYADLNATLDYRHRHTLFGRDSETTVGLRVAHDLDANVRESLRFASNGYAAGTRTRDFRHLGTNSTLHIGNNLAMNDRLRVQTGLALINTRSDVQVTWPTSGGRLRDHDWDYAPRLGFTWQHSAQTQWFGNLSRSVEAPHPWSMIWGSNQFFGTGNGPSTGRQSTPVAMQNQTATTLELGARGEAALGRWELTGYYAHVNHELLSVELQPVPNLFVAENNASPTVHRGIEAGVDSTLWQDAPGRLSLRQAYTFSDFRYRHDTRFGSNRLPGLPQHSYQAELRFDHASGLYAALNTEYASRIAVDYANSYWADSHVIFGSRLGYDAPGGRWQAWAEMRNIGDRHYAATVTPGYDDAGKDVARSTPGEGRGVYAGVRWRFD
>NZ_CP018756.1|WP_079222366.1|2394329_2396717_-|GH92-family-glycosyl-hydrolase
MSRSLLVVVSAVLTLSPLPLLAARAPAQDLAAEVNPFIGTTNAGNVYPGPTVPFGMVAFSPEMTALPGKRFPIAAPGGYEWRSNGVRGFSLTHVNGTGCTGASGDIPLMPVTLPVELSPSSADAGVRYTSLLDHAKETASPGAYTLTLDNGVAVSLAATARTAVGQFQFPADKPANLLFRTSDSEVGSSDSTIIIDPATRTVRGSVTSGNFCGYLAEDRRESYYTLHFVAEFDQPFEVGGTWRDDTVQAGAREGSGGTTYGSKGHPPAGKGAGGWISFDAKRTPQVTARIGISYVDEAGARANLRRESPQGTTVAATQAATRAKWNELLGQVRVQGGTADERTVFYTALYHAMLAPNLHSDGDGRYRGMDGKVHSLSKRQQAQYANYSGWDVYRSQLQLLTLLQPQVGSDVAQSLLNQADQNGGVWDRWTHITGATGVMNGDPSPPSVAAIHAFGGRSFDLQRAYASLKKAATVPTARDLDKRGCPVLCVGQRPGLDQWLALKYMPEGAPGWGSAADTLEMVSADFGLSELALAAGDAQGAKQFRERSGWWRNLYNPKATAQQGYIQPRNADGSWPTFDPAADDGFVEGSGAQYLWMVPFDPAGLFEVLGGRDASIARLDAFFRKEDGAWAVTKSGPLHAELDNEPSIAAPWLYNFLGQPWKTQETVRQAMRQIWTNTPEGMPGNDDLGQMSSWYVWSALGLYPVYPGRADLVIGSPLFTEAVITRPGAKIVVRARGAAMDAPYVQSLQVDGKASNASWLPASFVQRGGTLDFELGTTKNEQWGAQDVPPSHGPR
>NZ_CP018756.1|WP_079222367.1|2396854_2397196_-|hypothetical-protein
MTSVATGRTGIGWLLIGLLCSGVAAVGCTVLGRFAIPQFVESFAEAGQPLPVITQVFAGSYGLVWLAPLAVVATWLAGRARTSALIGCIALMLATPVALFAAYLPLFKLGTLF
>NZ_CP018756.1|WP_079222368.1|2397214_2397541_-|hypothetical-protein
MKAIVLAVSLSLAIAPAIAPAQELTGELAALGITAGMPYAKAKRLLDAAGWRVTPPESAQAALPDFPEIECGQGRDAVCSAGFHKDDQTVAMIIGTTQAGQPYVQGTY
>NZ_CP018756.1|WP_079222369.1|2397740_2400203_-|S9-family-peptidase
MLIHRTSLAAAIAVATFGLLAAGPALADYAKPPEHLLKVLKAPPPPAPNVDPSGQRLLLTTAQTYPSIARVAQPYLKLAGVRLEPKNRSRHDTPGGYGIPACVADFSVVEIASGKTTKVDLPQGCAGAAQWSADGSHFAFQNAVDTSVQLWVGDAATGQVKQVPGVQLNPIFGSTVQWLGGSQNLLVKLVPANQGAAPSDGGVPTGPDAQESLGSSGESSTYEARDTLTSAHDEKLFAYYGASQLAVVDTASGKVRPVGSAAIFNDVNAAPDGVHVLTESIKPPFSHAVTYQRFANDVAVLDITTGKATAIASLPLADRVPVHGVPEGPRGFDWRSTDPATLVYAEALDKGDWKVTVPHRDRVLMLKAPFNGKPVEIARTAQRFEGLAWSADPAVSFMFENDENRHWVQTRIVDVDQPKKEGRLLWDMSSDELYGDPGNLVFKRLPNGAAVVRQEGNFVFLRGQGASPQGDRPFLDRLDLGSLKSERLFRSSADAYEQFLGFSNTPGRYLTWHQSVVDAPNAFVRQQGEAVAAAKDGEAQFASTATALTKLVDPTPEVRQIKKQLVTYKRADGVDLSFTLYTPPGYKEGQRVPAILYAYPADFANAAQAGQVSGSQQTFTRLQPYRLMLLAGYAIIDNASFPIVGDPKTAYDTYLEQLEADAKAAVDKAVDMGVVDRNRIGVTGHSHGGLMTANLIAHTNLFKAGVATSGSYNKTFTPFGFQNERRSVWQAQDVYLKASPFFYADKIKLPLLLVHGEDDANPGTEPFQSRKLYQAIRGNGGTTRLVMLPNEPHWYTALESNEQLVSEMLNWFDTYVKNAK
>NZ_CP018756.1|WP_079222370.1|2400336_2400666_-|hypothetical-protein
MNDESNPLLPTLDDAKAEQMIGKVVLVGITRYGGDGQMRDQQQYSGTVLRISAEEGVVLADEADGHERYLPPMLDQYLPAEPGEYRLRSGGEIVVDPDYLTTWDLHAQQ
>NZ_CP018756.1|WP_152027098.1|2400943_2401558_-|hypothetical-protein
MAWGVDEIYLAATERAVAWATGSPFAHISYLVKDPVASCDARGDEHRHSVGAQGLLVLRGVGSPQGFQSGRMPGAVHWDGLRPDAGAAPVDAAVGAQLQAYITQMDMRGLDAPDAFRAWLREVSLRLQQPLMFYTASTFGGTCDYDYALTYTPNERLHATRFEGLRPCSPTALQSGLACLSITLPTSYFALHERSFDWASRALL
>NZ_CP018756.1|WP_079222372.1|2401651_2402428_+|aminotransferase-class-I-and-II
MRTVHALRYITPLREGGSLPAVVETDDDGMAVLKFRGAGQGPKALIAELIAGEMARSVGLPIPEILFVELDSEFARTEPDPEIQDLIRASEGLNLGLDYLPGAINYDPAAMPVDADLASRLVWFDAFTSNVDRTTRNPNLMVWHRKLYLIDHGAAMYFHHDWANAGDACEKPFVLIRDHVLLPFASRIAEVDAELAARLPDAEIERIVGLVPDSWLVDEPAFDSPQAYRQGYINYLKHRLKVRAVFVQEAIRAHAAHV
>NZ_CP018756.1|WP_079222373.1|2402405_2402798_+|DUF3037-domain-containing-protein
MPTLHTYDYAVIRVVPRVEREEFINVGVIVSCPGARHLEAAIEIDAARLQAFAPALDLEALQPWLDAIVAICRGDANAGPIAQLPARARFHFLTAKRSSIVQMSSTHVGRTADPAGVVEHLMTKMVRVPR
>NZ_CP018756.1|WP_079222374.1|2402810_2403986_-|ankyrin-repeat-domain-containing-protein
MSDRHALGIEHESELVRLYNAVEAGDLDVVRAIAAAQPALLRLAYFGNAGSKSVLHMAAASGQEAVCHWLLAWGLPVDVSFSGNDGATPLMAAVNGGHAAVCTLLLQAGANPDGTALVACPPLYAAAVAGRGDIVELLLHAGADVNRLHRQMNQSPLDVARIWKHPAVAATLEHQGGRSVRDYEGPYVQGPGESIIVFVHNTAGPVLRPEFSPVSRDPRASLHVSLIDGKSDFKLLFTTGLHGAGTPMTELFLCLQGNWPLPRTGLADDSVWRFPELLLSRMVEKLFTQGPIGEGHLVERSDPAFTDLPWPEDVDALLALDKPWNPVNERDSIPPHQRVTLLVLAPVKYTRKGRPDAGALATLLERKRKASWRVLSLRRDDSRIRLAVLPG
>NZ_CP018756.1|WP_079222375.1|2404067_2405480_-|serine-hydrolase
MFVRCLATRQLFWALLMLLCMGAAHAARPVPEAQRAADDWLAAFNAGSLEGLQAFAERYAKKDGSTPQDYLEFRESTGPLKLLEVRESAPLQAKLLVLAQQTERAMLVTAEMDPAHPEHLKLFQLEGTPTPEQYQPARVPLPALMADARAKLDALAAEDALSGTVLVAQNGRVLLDWSGGLADRRANKAVDARTQFRLASSNKMFTSVAILQLVQAGKVSLDDTIGKHLPDYPNKAVAETVTVRQLLTHTSGLGDFFGDDFDQYSASLKTLDDYVQRFAKDAPQFTPGSQDSYSNYGFIVLGRIIEAVSGQSYYAYVDEHILRPAGMTGTGFEPETVDVVQRAVAYTKKEGQWMRETRSLPWRGMSAGGGYSTAADMLKFCEALRSGKLVSPALLRQATTAQNHKGWYGFGFVVQGQGSLRQYGHEGGAPGSNSAIVVLPEQGYVVIGLANVDPDAVGNVVNYIARRLPL

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Crispr_ID: NZ_CP018756_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_14

2463278-2463443

Orphan

Consensus_repeat	Method
CAACGGCCTGGACCTGGCCCTGCTG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP018756_14

>merge|NZ_CP018756|14|2463278-2463443|CRISPRCasFinder
CATCGGACTGGGCCTGTTCGCCCTGCACCGCGCCGCCCGCGACGGCGGCCTGCACGTCGATGGCGAGGACGTGAACATCAACGGCCTGGACCTGGCCCTGCTGACCCAGAAGATCAGCGCCAAGGACATGGCCGACCTCGGCAACGGCCTGGACCTGACCCTGCTG

>NZ_CP018756|14|14|2463278-2463443|CRISPRCasFinder
CATCGGACTGGGCCTGTTCGCCCTG	CACCGCGCCGCCCGCGACGGCGGCCTGCACGTCGATGGCGAGGACGTGAACAT
CAACGGCCTGGACCTGGCCCTGCTG	ACCCAGAAGATCAGCGCCAAGGACATGGCCGACCTCGG
CAACGGCCTGGACCTGACCCTGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222409.1\|2456088_2457276_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|372338
NZ_CP018756.1\|WP_079222419.1\|2464184_2465072_+\|DUF2807-domain-containing-protein	unknown	unknown	gnl\|CDD\|226123
NZ_CP018756.1\|WP_079222427.1\|2475388_2476591_+\|dihydrolipoyllysine-residue-succinyltransferase	unknown	unknown	gnl\|CDD\|235571
NZ_CP018756.1\|WP_079222424.1\|2470008_2471424_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|225406
NZ_CP018756.1\|WP_079222412.1\|2458253_2459603_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP018756.1\|WP_079222410.1\|2457324_2458011_-\|DUF2058-family-protein	unknown	unknown	gnl\|CDD\|225664
NZ_CP018756.1\|WP_079222421.1\|2465827_2466253_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222423.1\|2467982_2469350_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|236452
NZ_CP018756.1\|WP_079222420.1\|2465103_2465721_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378556
NZ_CP018756.1\|WP_079222407.1\|2452264_2453359_+\|homocysteine-S-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|236539
NZ_CP018756.1\|WP_079222413.1\|2459625_2460603_-\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_CP018756.1\|WP_079222422.1\|2466310_2467750_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP018756.1\|WP_079222408.1\|2453355_2456040_+\|methionine-synthase	unknown	unknown	gnl\|CDD\|236539
NZ_CP018756.1\|WP_079222411.1\|2458021_2458261_-\|SlyX-family-protein	unknown	unknown	gnl\|CDD\|179141
NZ_CP018756.1\|WP_079222416.1\|2461906_2462266_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_CP018756.1\|WP_192851850.1\|2460699_2461185_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NZ_CP018756.1\|WP_079222426.1\|2472516_2475348_+\|2-oxoglutarate-dehydrogenase-E1-component	unknown	unknown	gnl\|CDD\|236499
NZ_CP018756.1\|WP_079222417.1\|2462265_2463141_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP018756.1\|WP_079222425.1\|2471427_2472330_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP018756.1\|WP_079222428.1\|2476654_2478091_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235779

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222409.1\|2456088_2457276_+\|MFS-transporter	gnl\|CDD\|372338	pfam12832, MFS_1_like, MFS_1 like family. This family contains proteins related to the MFS superfamily.	2.9631e-83
NZ_CP018756.1\|WP_079222419.1\|2464184_2465072_+\|DUF2807-domain-containing-protein	gnl\|CDD\|226123	COG3595, COG3595, Uncharacterized conserved protein [Function unknown].	2.27841e-07
NZ_CP018756.1\|WP_079222424.1\|2470008_2471424_+\|cupin-domain-containing-protein	gnl\|CDD\|225406	COG2850, COG2850, Uncharacterized conserved protein [Function unknown].	6.30257e-131
NZ_CP018756.1\|WP_079222412.1\|2458253_2459603_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP018756.1\|WP_079222410.1\|2457324_2458011_-\|DUF2058-family-protein	gnl\|CDD\|225664	COG3122, COG3122, Uncharacterized protein conserved in bacteria [Function unknown].	1.84263e-44
NZ_CP018756.1\|WP_079222427.1\|2475388_2476591_+\|dihydrolipoyllysine-residue-succinyltransferase	gnl\|CDD\|235571	PRK05704, PRK05704, 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase.	0
NZ_CP018756.1\|WP_079222423.1\|2467982_2469350_+\|adenylosuccinate-lyase	gnl\|CDD\|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
NZ_CP018756.1\|WP_079222420.1\|2465103_2465721_+\|hypothetical-protein	gnl\|CDD\|378556	pfam11101, DUF2884, Protein of unknown function (DUF2884). Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.	3.89492e-06
NZ_CP018756.1\|WP_079222407.1\|2452264_2453359_+\|homocysteine-S-methyltransferase-family-protein	gnl\|CDD\|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
NZ_CP018756.1\|WP_079222413.1\|2459625_2460603_-\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	3.92944e-64
NZ_CP018756.1\|WP_079222422.1\|2466310_2467750_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP018756.1\|WP_079222408.1\|2453355_2456040_+\|methionine-synthase	gnl\|CDD\|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
NZ_CP018756.1\|WP_079222411.1\|2458021_2458261_-\|SlyX-family-protein	gnl\|CDD\|179141	PRK00846, PRK00846, hypothetical protein; Provisional.	3.59044e-31
NZ_CP018756.1\|WP_079222416.1\|2461906_2462266_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	2.86218e-32
NZ_CP018756.1\|WP_192851850.1\|2460699_2461185_-\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	1.6703e-80
NZ_CP018756.1\|WP_079222426.1\|2472516_2475348_+\|2-oxoglutarate-dehydrogenase-E1-component	gnl\|CDD\|236499	PRK09404, sucA, 2-oxoglutarate dehydrogenase E1 component; Reviewed.	0
NZ_CP018756.1\|WP_079222417.1\|2462265_2463141_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.05528e-62
NZ_CP018756.1\|WP_079222425.1\|2471427_2472330_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.01413e-18
NZ_CP018756.1\|WP_079222428.1\|2476654_2478091_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235779	PRK06327, PRK06327, dihydrolipoamide dehydrogenase; Validated.	0

>NZ_CP018756.1|WP_079222417.1|2462265_2463141_+|ABC-transporter-ATP-binding-protein
MSTVASEAVITAKGLRKAYKNTVALDNASFSIPAGRIVGLIGPNGAGKTTALKAILGLTSVEGELSVLGRDPRAHRDELMKDICFIADVAVLPRWLKVREAIDFVAGVHPRFDRARCERFLANTKLQPRQRVRELSKGMIVQLHLALVMAIDARILVLDEPTLGLDILYRKEFYQRLLEDYFDEQKTIIVTTHQVEEIEHILSDVMFIRDGRVVLSAEMDEVGERYTELLVGADQLETARALKPIDERAQAFGKTVLLFDGVPRSQLSTLGETRNAGLADLFVAVMKGTYA
>NZ_CP018756.1|WP_079222416.1|2461906_2462266_+|GntR-family-transcriptional-regulator
MSDIQWSDGAPIYRQLKERVIAMMLDGILKPGDALPSVRQVAADYQLNPITVSRAYQELADEGLVEKRRGLGMFMTEQAATQLRSSERERFLNEEWPAVLERIQRLGLSLDELLPQGKI
>NZ_CP018756.1|WP_192851850.1|2460699_2461185_-|glutathione-peroxidase
MLDVSYRPLAGKQQVNLEKRYHGQVLLVVNTASKCGYTPQYEGLEALHKQYASKGFAVLGFPSNDFKGQEPGDEKQIQDFCTLTYGVKFPMFEKVHVVGAEATPLYQRLTAATGVAPGWNFHKYLVGRDGKVIAQFASKVTPDDPQLKAAIDKALAAPATH
>NZ_CP018756.1|WP_079222413.1|2459625_2460603_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MKMGMRGAAASVLILAMGTSGVALSQQPAAPAAAKETATLNSPKQKLGYAIGLDVAKSFAPIADEIDVAALRTAVERSFEGLQPQITQDQAKATDAALRQVVMARNGQQVPGMAPGSQPAKVDRVKVAQMIGSYSVGPSLAQLKDDIDTASLFDAISTALSKGQPKMTEADATATIQSFMSTKQAEMQAKAAQAAQTNRQEGNAFLAKNKTQPGVVTTASGLQYQVIRPGSGERPLPSSKVRVNYEGKLLDGTVFDSSASRGPAEFGLDQVIKGWTEGVALMPVGSKYRFWIPGDLAYGENGTPGGPIGPNATLTFDVELLGVLP
>NZ_CP018756.1|WP_079222412.1|2458253_2459603_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MRVAIFGTGYVGLVTGTCLADAGHQVVCVDIDQAKVDGLNQGIIPIYEPGLEPMVKANHAASRLAFTTDAAAAIGHGQVVFIAVGTPPDEDGSADLQYVLAVARTIGRHMSVPTVVVNKSTVPVGTADKVRAAIAAELSARGADIAFDVVSNPEFLKEGDAVADCMRPDRIIIGATSAESVAVMRRLYAPFNRNHDRVVEMDVRSAELTKYAANAMLATKISFMNEIANIAERVGADIEQVRQGIGSDPRIGWHFIYPGAGYGGSCFPKDVQALASTAQQYGLEPKLLNAVEAVNDAQKGHLFELIQRHYGTDAGASLRGKTFAVWGLAFKPNTDDMREASSRRLLAQLWDAGATVRAYDPEATHEAQRIFGQRDDLVFCGSADEALQGAAAVVVVTEWKQFRSPDFQALRSQLKDAVVFDGRNLYDPSEVEAAGLAYYGIGRGRSLHV
>NZ_CP018756.1|WP_079222411.1|2458021_2458261_-|SlyX-family-protein
MSELPSEREQALEARLVELEMRVSFQEHALAELSDALAAASMQGSRNADVLRVLLEDLGKVRNALNSSDPASEPPPPHY
>NZ_CP018756.1|WP_079222410.1|2457324_2458011_-|DUF2058-family-protein
MSDTLRDQLMGLGFKPAPKPERKNDAPRRDGRPQGKGGNGDGNARPQGVGKGEQKPGERRGHGRGGAGKPSPSRGPGQQGPRKPRTAEEMDLAKAYAIRAQKEKEERIETERLKQEEARQRREAKAKLEELLKDKGLNDEAADIARHFPYGGKIKRIYVTAAQLTALNAGELGVVQLNGRYLLVTAELLAQSEAVFAASVALKVDPNAPAEEDPYADPQFQVPDDLVW
>NZ_CP018756.1|WP_079222409.1|2456088_2457276_+|MFS-transporter
MTVPATRLSSFYLFYYAALGAFTPYWSLFLTARGMSVTAISVMMGLWYATRVIAPSTWTSLAAASPRPIRLLRVGCVLTLLSFAVFLLPLPQPWMYPAMVVFCFFYNAVMPQFESITLTHLGSDSHRYGLIRVWGSLGFIAIVTLFGWLIEGDGSGSRAGLLPWMMLPLFALLVASAFSNQYARGIGKAEGDASGFWQIVRRPPVLAFFLAAFMEQLSFGPYYTFFSVYMDHHGYRTSTLGLLWTIGVVFEVGVFFTIGRFFRRYDASWMLLIALVSSCLRWAVTALFPENLPVMLVAQTAHALGFAAFFAAAMQMLATYFPGRLNGHGQGLLYGFSSGVGGVLGALIAGQLWPIDNGRTAFLAGSGFALVGALLSFFALSLPLIRARRSATGTH
>NZ_CP018756.1|WP_079222408.1|2453355_2456040_+|methionine-synthase
MSTSPYTRLSGLEPLVITPDLLFVNVGERTNVTGSAQFRKLIKEGRYEEAVDVARQQVASGAQILDVNMDEGLIDSEAAMTRYLNLIMSEPDIARIPVMVDSSKWSVIEAGLKCLQGKSVVNSISLKEGEALFREHARKVLRYGAAAVVMAFDEAGQADTCARKVEICTRAYRILVDEIGFPPQDIIFDPNIFAVATGIEEHDNYAVDFIEATRIIKQTLPHCHVSGGVSNVSFSFRGNETVRQAIHSVFLYHAIAAGMDMGIVNAGAMPIYDELEPELRERVEDVILNRRSDATERLLEIAERYKGKKGAAKTEDLAWREKPVAQRLAHALVHGLDAFVEEDTELARQASSRPLDVIEGPLMDGMNVVGDLFGAGKMFLPQVVKSARVMKKAVAYLLPYIEAEKARSGDTARSNGKIIMATVKGDVHDIGKNIVGVVLACNNFEVVDLGVMVPAQKILDAAREHNADLVGLSGLITPSLEEMSHVAREMERQGFDLPLLIGGATTSRAHTALKIDPHYKAPTVWVKDASRAVGVAQSLISRDLREAFVAANEADYAEIRARHRNRGDAKRLVSLEHARGQKFQGDWVNYTPPAPRQPGLHVFDDYPLAELVDYIDWTPFFQAWELAGKYPAILTDEIVGTQASELYRDARAMLDRIVGEKWLQAKAVFGLWPANSVGDDVRVQHPQGETTLHFLRQQVDKPAERPDFCLADFIAPADSGRQDWIGAFAVTAGIGIDAHVARFEADHDDYNAILLKALADRFAEALAERLHQRVRTEFWGYDHAEKLDNEALIDEKYRGIRPAPGYPACPEHSEKRRLFDLLQAEANAGMELTESFAMLPTAAVSGYYFSHPQSQYFVVGRLSREQVSDYARRKGVDRAQAERWLASNLDYDPE
>NZ_CP018756.1|WP_079222407.1|2452264_2453359_+|homocysteine-S-methyltransferase-family-protein
MSALPWLHPERAHALLAALRERILIIDGAMGTMIQRHGLQEADYRGERFAGGYDHSHGPGCDHGTPEGHDLKGNNDLLLLTRPQVIGDIHTAYLQAGADLVETNTFNATSVSQADYHLEHLVYELNKAGAAVARACCDAVEATTPDKPRFVIGVIGPTSRTASISPDVNDPGFRNTSFDELRDTYREAIEGLIDGGADTLMVETIFDTLNAKAALYALEEAFDARGARLPVMISGTITDASGRTLSGQTADAFHASLAHARPLSIGLNCALGADAMRPHVETLSQVADCHVSAHPNAGLPNAFGEYDETPEEMAATLRGFAEDGLLNLVGGCCGSTPDHIRAIAEAVAGLPPRALPGAQEQQAA
>NZ_CP018756.1|WP_079222419.1|2464184_2465072_+|DUF2807-domain-containing-protein
MRTLLACSALLLLLPLSVQAADAPNCKLSAPRSLKLDTAGAKAVVFEVNQHDLKVVANAGGGQLEGRACASSQELLDQLRLDQRREGDKLVVSLRRDSRPGISLGNFHAWLDIRGSVPDNLPLQFRIGSGDASVDNAQSLSMDVGSGDGIARGTRGSVHAAVGSGDLDIDGAASLNLLSLGSGDVKARNIGGDAVVGTVGSGDLKISDVRGNARLETVGSGDIGFRQVKGNVEIGVVGSGDVDIDQTGGNVHVRSHGSGDITVNGAGGNLTVDHSGSGDVRHRDIGGKVTLPRGK
>NZ_CP018756.1|WP_079222420.1|2465103_2465721_+|hypothetical-protein
MNLLRLMPAVLLCLPLIACGGTSSSSSSPSDTSPGKAVADATGEIGKSVKEATDKAREEIAKGNIKISSDKQPRAEITPDGRLLIAGKEVETTPAQRRQLLDYRGQIAGIAQDGMEIGVAGAKLGASAASEAIKGVFSGDTDGIEKRINAEAEKIEAQAKQLCSRLPAMLASQQALARDLPAFQPYATMDQRDIDDCNTNTVVNR
>NZ_CP018756.1|WP_079222421.1|2465827_2466253_+|hypothetical-protein
MKKLLLLLVALLCLGLAGCDQDYRNHRAERGKPKISVSESMVTVRRQPAPNIIILPDGTMKVDEIQIPLNDGQRQMLQTMFGKLQVLRQNTLVAAPADPNMQPVKIQPPEGMEVIPPDLVQVIPEFKDYTETFGNIVADRR
>NZ_CP018756.1|WP_079222422.1|2466310_2467750_-|class-II-fumarate-hydratase
MSKAASKGGTATFRIEHDSMGELQVPADALWGAQTQRAVENFPVSGQRMPRGFIRALGLVKGAAAGVNAELGHLPKVVAKAIQVAAAEVSAGQWDAHFPIDVYQTGSGTSSNMNANEVIATLANRAGKAGKTVVHPNDHVNQGQSSNDVIPTALRVSAVLAVHEHLLPALVHLRKTLDKKGRSLRKVVKTGRTHLMDAMPLTFEQEFGAWSAQLASAQERIEDSLKRVRRLPLGGTAIGTGINADPRFGEQVAKALKQQTGVKFDSAANKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKVNPVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLIAVNLLDGIGLLANVSVLLADSAIKGLKVREDRVAEALARNPILVTALNPIIGYEKAAAIAKRAYKEQRPVLDVALEDSGLDEAELRRLLDPTALTAGGIQAGGGGAGG
>NZ_CP018756.1|WP_079222423.1|2467982_2469350_+|adenylosuccinate-lyase
MSDYALLALSPLDGRYAGKVDALRPIFSEYGLIKARITVEVEWLLALGAEPGIVELAAFSEAATTRLRALAANLTPAQAARVKEIERTTNHDVKAVEYFIKEQLKDDAELAPALEFVHFACTSEDINNLSYGLMLEQARREVLLPSLDGVAATLRTLAHAQAAQPMLSRTHGQTASPTTLGKELANVVARLERQRRQIAAVELTGKINGAVGNYNAHVASYPDVDWPAFAERFVTSLGLVFNPYTTQIEPHDNIAEIGDAARRANTILIDLARDIWGYISLGYFKQRLKEGEVGSSTMPHKVNPIDFENAEGNFGIANALFEHFSAKLPISRWQRDLTDSTVLRALGTAFGHGQVALDSLAKGLGKLEVNPQRLDADLDAAWEVLAEAVQTVMRRHGLPNPYEQLKALTRGQGITAESMRVFVETLALPEDAKQSLREMTPGSYTGLAEALARKI
>NZ_CP018756.1|WP_079222424.1|2470008_2471424_+|cupin-domain-containing-protein
MAARKSTAPLIEVTARPGKPLGMAPATFLRDFWQKRPLLIRNAFPDFQTPVQPEDLAGLACEEGVLARLIQHDKAQDGWRVRSGPFQEEVFPALPDRDWTLLVQDVDKWDPDVRALIEHFSFLPRWRMDDVMISFAATGGSVGAHVDQYDVFLLQAHGHRRWQIDASESIKGKRPPLGFRPDVELKLLQVFKPTHDWVLAPGDMLYLPPNVPHHGVAEDPCLTFSFGMRAPASAELISDYLDTLIADADENIRYQDPDLKVPADPNEIDTVAMARVITALNAIRMNDPDKLGDWFGRFITTYRAAGEVMAHQAAPAPEEVVQALASGLLLQRHPWARLAWRRAKRGASLYVSGQDFALPVKDAQRLAGAEQMDAAAYRGLSDKGRAVLQQLLVGGVFQLIDPNEVFDAEDEDEGEDAAVLGEVVEGHDQVAELDDEVVSDDVHTVNVHDDGIEVIVNFEDHDEDDSNDGRA
>NZ_CP018756.1|WP_079222425.1|2471427_2472330_+|GNAT-family-N-acetyltransferase
MATIRVQQVSHADAHAAIHDVRQRVFVQEQGIAAELERDALDPVSAHALALDADGQPVGTGRLAPDGRIGRMAVLASHRNQGVGEALLDALVEAGRALGLAEVHLHAQLPARDFYARQGFLPEGAVFEEAGIGHQQMRRRLGVASAIDSRAEAVAITTAIIHRARRQLWLHSRQLDPRLLDAAPVQAALRRFVTARHDKQLRVIVHDAAAIAADGSPLLALAQRLPSVIQFREVSDPIDRALASACLVNDAGDFYFRLIGHRLDGEAGIALPARSQPFEQQLQRVWDRSRDCSELRALGI
>NZ_CP018756.1|WP_079222426.1|2472516_2475348_+|2-oxoglutarate-dehydrogenase-E1-component
MDNQLKQFAQSSQLAGGNASYVEDLYEQYLVSPDSVDPKWKTYFDGFKGREAGDIPHSAVISHIADAAKDALKAGTGTGAGDERERNVGRLITAYRSRGHLDARLDPLGLTTPVNTPDLGLPFHSLSDGDLNSEFSTGGVGGQPRMKLRDLLARLKATYTGSIGAEFMHIAEVEQRQWIYKKLELAGGNYQLDADTQRRTLERLTAAEGLERYLHTKYVGQKRFSLEGGDSLIPMMDTIIRSAGKDGVKDVVVGMAHRGRLNVLVNTLGKNPRKLFDEFEGKFEHDEHASAGDVKYHMGFSADVATDGGPVHLALAFNPSHLEIADPVVAGSVRSRQERRKDTARKQVMPILIHGDAAFSGQGVVMELFQMSQARGFAVGGTVHIVVNNQVGFTTSNPLDTRSTRYATDVAKMIAAPVLHVNGDDPEAVVFAAQLAFEFRQKFAKDVVIDLMCYRRWGHNEADEPAITQPLMYQVIRKHPTTRELYAEQLEKAGVIAAGAGKAMVDAYRDKLDGGEVTTELAKVEKTPPTSPLFVDWPKLLEGKLSDEISTKVDKDKLVELAKLINTVPEEVQLHSRVSKVYDDRRKMAAGEIPGDWGFAENLAYATLLDEGNALRLVGQDVGRGTFTHRHAILHDQKTDNYYLPLRQLVDSPEKATIIDSLLSEEAVMAYEYGFSTTDPNTLCIWEGQFGDFANGAQVVIDQFIAAGEAKWGRITGLTLLLPHGYEGQGPEHSSARLERFLQLCALENMLVVVPSTPAQAFHMLRRQQHLTTRKPLVVMSPKSLLRHKLAVSTLDELANGEFQHLIGDANADAKKVKRVVLCSGKVYYDLLEDQTKRGQDDVAIIRVEQLYPFPRALLAAELKKYGKATDVVWTQEEPQNQGAWYQIRHHLQFCLADGQNLHYAGRARSASPAAGHMADHVREQQQLVADALVNPFNDTFAE
>NZ_CP018756.1|WP_079222427.1|2475388_2476591_+|dihydrolipoyllysine-residue-succinyltransferase
MATEVKAPVLPESVADGTIATWHKKVGDAVKRDENLLDLETDKVVLEVPSPVDGVIKEIKFKEGDTVTSSQVVAIIEEGAVAAAPAPAAEAAPAAAAAPAAAAPAAAAAPAPAAKSAADTLPPGARFTAITEGVNPADVDGTGRRGAVTKEDIVNFARNGGAGKAGGARPEERVPMTRIRKRIAERLMESKNSTAMLTTFNEVDLSKVSAARKDLQDEFVKAHGIKLGFMSFFVKAAANALQRFPLVNASIDGDDIIYHGYSDISIAVSTEKGLVTPVLRNVERMSFADIEKTIADYAKKARDGKLGLEELQGGTFTVTNGGTFGSLLSTPIINPPQSAILGMHAIKERPIAQNGQVVIAPMMYLALSYDHRIIDGKDSVQFLVDIKNQLENPGRMLFGL
>NZ_CP018756.1|WP_079222428.1|2476654_2478091_+|dihydrolipoyl-dehydrogenase
MAEQFDVVVIGAGPAGYHAAIRAAQLGLKTACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHIFGDHGISFKDAKIDVEAMVGRKDKIVKQFTGGIAMLFKANKVATYYGFGELQPGNVVKVKQHDGSEVELKGTNVIIAAGSDSIELPFAKFDGDVIVDNVGGLDFTEVPNRLAVIGAGVIGLELGSVWKRLGAEVTILEALPEFLAVADAEVAKTAAKEFKKQGLDIRLGAKVSKTEITGKGKKKEVVVTYTDSEGEKTLTVDKLLVAVGRRAATKGLLAEGTGVKVNERGQIEVDAHCHTGVNGVWAVGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPELAWVGKTEAQLKAEGIPYKAGSFPFAANGRAVAMIEPAGFVKILAHAETDRILGMHLVGANVSELVHEGVLTMEFSGSADDLARICHAHPSLSEVIHDAAMAVSKRAIHKAN

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Crispr_ID: NZ_CP018756_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_15

2532868-2532954

Orphan

Consensus_repeat	Method
AGGTTGGCACCTACCAGAGCGCCGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_15

>merge|NZ_CP018756|15|2532868-2532954|CRISPRCasFinder
AGGTTGGCACCTACCAGAGCGCCGTTGATTCAACGCGCGCGGACACGCCCGTGCCAACCGAGGTTGGCACCTACCAGAGCACCGTTG

>NZ_CP018756|15|15|2532868-2532954|CRISPRCasFinder
AGGTTGGCACCTACCAGAGCGCCGTTG	ATTCAACGCGCGCGGACACGCCCGTGCCAACCG
AGGTTGGCACCTACCAGAGCACCGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222472.1\|2527063_2527873_+\|zinc-transporter-ZupT	unknown	unknown	gnl\|CDD\|235253
NZ_CP018756.1\|WP_079222468.1\|2523738_2525502_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP018756.1\|WP_079222470.1\|2526202_2526553_+\|4a-hydroxytetrahydrobiopterin-dehydratase	unknown	unknown	gnl\|CDD\|234845
NZ_CP018756.1\|WP_079222466.1\|2522805_2523267_+\|ribonuclease	unknown	unknown	gnl\|CDD\|238340
NZ_CP018756.1\|WP_079222471.1\|2526549_2526966_+\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NZ_CP018756.1\|WP_079222467.1\|2523263_2523677_+\|barstar-family-protein	unknown	unknown	gnl\|CDD\|240164
NZ_CP018756.1\|WP_079222473.1\|2527971_2528946_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|182909
NZ_CP018756.1\|WP_079222477.1\|2537152_2537989_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP018756.1\|WP_079222480.1\|2540208_2541813_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227662
NZ_CP018756.1\|WP_079222481.1\|2542061_2545121_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379297
NZ_CP018756.1\|WP_079222482.1\|2545197_2546235_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP018756.1\|WP_079222478.1\|2537985_2538867_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP018756.1\|WP_079225292.1\|2546655_2546955_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|183103
NZ_CP018756.1\|WP_079222475.1\|2533095_2533986_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197317
NZ_CP018756.1\|WP_079222479.1\|2538863_2540204_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP018756.1\|WP_079222483.1\|2546383_2546659_-\|BolA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376601
NZ_CP018756.1\|WP_079222469.1\|2525512_2526112_-\|NfuA-family-Fe-S-biogenesis-protein	unknown	unknown	gnl\|CDD\|132384
NZ_CP018756.1\|WP_079222465.1\|2521971_2522583_-\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP018756.1\|WP_079222474.1\|2529353_2532653_+\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|236766
NZ_CP018756.1\|WP_079222476.1\|2533988_2537156_-\|discoidin-domain-containing-protein	unknown	unknown	gnl\|CDD\|366285

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222472.1\|2527063_2527873_+\|zinc-transporter-ZupT	gnl\|CDD\|235253	PRK04201, PRK04201, zinc transporter ZupT; Provisional.	8.65995e-127
NZ_CP018756.1\|WP_079222468.1\|2523738_2525502_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.56369e-17
NZ_CP018756.1\|WP_079222470.1\|2526202_2526553_+\|4a-hydroxytetrahydrobiopterin-dehydratase	gnl\|CDD\|234845	PRK00823, phhB, pterin-4-alpha-carbinolamine dehydratase; Validated.	1.04828e-43
NZ_CP018756.1\|WP_079222466.1\|2522805_2523267_+\|ribonuclease	gnl\|CDD\|238340	cd00607, RNase_Sa, RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate specific endoribonuclease which belongs to the superfamily of microbial ribonucleases. Typical of this sub-family, the enzyme hydrolyses the phosphodiester bonds of RNA at the 3' oxygen end of guanosine residues to yield oligonucleotides with the guanosine-2',3'-cyclophosphate at the 3' end and the hydroxyl group at the 5' end. The terminal guanosine-2,3'-cyclophosphate is hydrolysed by guanyl RNAses to give guanosine-3'-phosphate.	1.16514e-42
NZ_CP018756.1\|WP_079222471.1\|2526549_2526966_+\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	4.53685e-18
NZ_CP018756.1\|WP_079222467.1\|2523263_2523677_+\|barstar-family-protein	gnl\|CDD\|240164	cd05141, Barstar_evA4336-like, Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.	1.1491e-26
NZ_CP018756.1\|WP_079222473.1\|2527971_2528946_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|182909	PRK11025, PRK11025, 23S rRNA pseudouridine(955/2504/2580) synthase RluC.	9.20794e-112
NZ_CP018756.1\|WP_079222477.1\|2537152_2537989_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.21471e-88
NZ_CP018756.1\|WP_079222480.1\|2540208_2541813_-\|hypothetical-protein	gnl\|CDD\|227662	COG5368, COG5368, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP018756.1\|WP_079222481.1\|2542061_2545121_-\|TonB-dependent-receptor	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	1.17725e-08
NZ_CP018756.1\|WP_079222482.1\|2545197_2546235_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.34002e-109
NZ_CP018756.1\|WP_079222478.1\|2537985_2538867_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.92799e-91
NZ_CP018756.1\|WP_079225292.1\|2546655_2546955_-\|YciI-family-protein	gnl\|CDD\|183103	PRK11370, PRK11370, YciI family protein.	7.13771e-59
NZ_CP018756.1\|WP_079222475.1\|2533095_2533986_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	1.09579e-22
NZ_CP018756.1\|WP_079222479.1\|2538863_2540204_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.49751e-140
NZ_CP018756.1\|WP_079222483.1\|2546383_2546659_-\|BolA-family-transcriptional-regulator	gnl\|CDD\|376601	pfam01722, BolA, BolA-like protein. This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.	3.0768e-34
NZ_CP018756.1\|WP_079222469.1\|2525512_2526112_-\|NfuA-family-Fe-S-biogenesis-protein	gnl\|CDD\|132384	TIGR03341, YhgI_GntY, IscR-regulated protein YhgI. IscR (TIGR02010) is an iron-sulfur cluster-binding transcriptional regulator (see Genome Property GenProp0138). Members of this protein family include YhgI, whose expression is under control of IscR, and show sequence similarity to IscA, a known protein of iron-sulfur cluster biosynthesis. These two lines of evidence strongly suggest a role as an iron-sulfur cluster biosynthesis protein. An older study designated this protein GntY and suggested a role for it and for the product of an adjacent gene, based on complementation studies, in gluconate utilization. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	2.48418e-72
NZ_CP018756.1\|WP_079222465.1\|2521971_2522583_-\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	3.73675e-108
NZ_CP018756.1\|WP_079222474.1\|2529353_2532653_+\|Rne/Rng-family-ribonuclease	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	0
NZ_CP018756.1\|WP_079222476.1\|2533988_2537156_-\|discoidin-domain-containing-protein	gnl\|CDD\|366285	pfam00754, F5_F8_type_C, F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.	6.58572e-14

>NZ_CP018756.1|WP_079222474.1|2529353_2532653_+|Rne/Rng-family-ribonuclease
MKRMLINATQAEELRVAIVDGQSLYDIDIEQPAKEQKKSNIYKGRIFRIEPSLEAAFVEYGGGRHGFLPLKEISRDYFQAGVDHNKAGIRELLKEGQEIVVQVDKEERGNKGAALTTFISLAGRYMVLMPNSPSAGGVSRRIEGEDRAALKDALDKLNIPDDMGVIIRTAGVGRDAEELQWDLDYLLNVWRAIAEAALSKPAPFLIYQESRLIVRALRDYLRADIGEILVDTEEMYEHAREFMQQVMPQTLRKLKHYKDDIPLFNRFQIESQIEGAYERNVRLPSGGSIVVDQTEALTAVDVNSSRATKGSDIEDTAFQTNLEAAEEVARQLRLRDLGGLVVIDFIDMASNKHQREVENRLANALKYDRARVQVGRISRFGLLEMSRQRLRPSLGESSQIVCPRCDGHGRMRSVESLSLSIIRVAEEHAMKENTGQVLVQAPVEIANYLLNEKRSALREIEKRHEAPIVIVADEQLHTPHYTVTRLRENELGEESNKPSYQRGTPRKLPVHALTKGQLNIPPPAVTQVKHTAPAPVRAEAEPVAAPAPAPVAAAPAPAASGGVVGWLKRIFGGEPAPAPAPAPAARQPQQDGGRKDRNKDRNKDRKDRRDDSRGNGGNANAQQQKDGGNRKDRGEQRKDGRQGGNNNGNAQQQPQQGKQKDAQQKDGQQQPQQQKPPRNEQQGQNPQQQPKLKQPKQPRPQQDGDKPAEKPQRSAAEAPVDTATAAAAVAATAVAANAVTAQEGTAPAAPVAPAADVLVADAAPVADAAANAGADADATAVSGEDAATDASGEQAGEGATRRRRGRRGGRRRRRGGAENAAGTDALGDDQDDGDESDDNDNDSTEQVADHAAEAAPVAAAQATRSQPEFDFDDEVEPVAVEAGKPARAPVAVAAAAPVVAVSSAVVDAVAPQDAAAQESAAKAEPKPQPVQTSMLDEIDAATPAQPAAPVAVVAEAKPVVEEAAVVAAPAPVVAEAAPVAEVAPVVEAKPVIAETAPVVEAAPVVADVASVVEAAPVVEAKPVVEAAPAVETAPVVEQPAAPVAVEAAPVEAAAPVAEAVVTPSIDPVADGHADSASQAADAQASDEDEEAAKRTPPAN
>NZ_CP018756.1|WP_079222473.1|2527971_2528946_-|RluA-family-pseudouridine-synthase
MTASDPTKPAGDKPSVRMITVPEDRAGQRLDNFLLGQLKGAPRSLVYKLVRSGQVRVNGGRAKAERKLEAGDEVRVPPVRLTEEGDKAGPPESFMRRLEQAIVFEDARLLALNKPTGVASHGGSGISFGAIETLRALRPGQTLELVHRLDRDTSGLLIVAKKRSALSELQALLREDHGAGIRKRYLTLLAGRMPDGVMTVDAPLHVGLRQGGERHVQVNAIGKESISHFRVLERKGGHSYCEVRIETGRTHQIRVHAQHLGHPVAGDDKYGDPAVNKRLREQIGLKRLFLHAASLEFALDAGKTPYVLNAPLADELVEALDRLR
>NZ_CP018756.1|WP_079222472.1|2527063_2527873_+|zinc-transporter-ZupT
MLQISPENFWIALAVTLAAGLATAIGSLLVLFSRRPSPRLLAFGLAFAGGAMVYVSLSEILNKSIASFALAYGERSGFTYGTIAFLLGVLAIVAIDHLIPNPHETLDSKEPAFLDNNKAYIKRVGLLTAVAITAHNFPEGLATFFATVESPSVGMPLAFAIAIHNIPEGIAIAVPVYFATQSKLHAFLASLLSGLAEPVGAVLGYFLLKGSLSHATFGWVFGLIAGVMVFLALDELLPAAKRYAKGHETVYGLVAGMGTLAISLVLFKW
>NZ_CP018756.1|WP_079222471.1|2526549_2526966_+|energy-transducer-TonB
MNVRLLSLSLLAATGLAGCGSSEPPAPPAAPPTEVAAVKTPPPQYPMELACTGVGGTSTFKVTIGTDGRPSEVLLLTGAGNAQLDDLARTAVQAWEFKAATRNGQAVPATIQVPVSFNPPQPKPDQCFAIEERMRRGG
>NZ_CP018756.1|WP_079222470.1|2526202_2526553_+|4a-hydroxytetrahydrobiopterin-dehydratase
MSDLIPLAQARCVPRKGSDHKLGEARLAELLPQVPGWELAEAGQALVRTFRFKDYYATMAFVNALAWIAHHEDHHPDLGVHYDRAVVRYSTHDVGGLSENDFICAAKTSALTEHVK
>NZ_CP018756.1|WP_079222469.1|2525512_2526112_-|NfuA-family-Fe-S-biogenesis-protein
MIQISDTAQTHFRKLIEREGVPGMGVRLSAVDPGTPRADARLEFAEPSDLLGDEWAVDCDGFTLYVDALSVGWLDGAEIDIVPGNAGTQQLTIKAPRIKGEAPGEAASLVERVHWVVENEVNPQLASHGGKVAVQEVSADGVVLLRFGGGCQGCGMADVTLKQGIEKTLMGRVPGVTAVRDATDHDSGHAPYIPRGNAA
>NZ_CP018756.1|WP_079222468.1|2523738_2525502_-|hypothetical-protein
MPLPRAEQLIDLLLARQQHPLILEKRTRLPYGWAIWLRSLKPIARPFHAGDVIAVLLPRPLPGRPGVLPALGPWGAARRLLWQDWEPAPRDQRWMRWTSAVASALLHLLFFLLLLWVAVIRTTAPEDAGAEGERVQIEFVGRGAQEGGGDQPGAEAAAAAEAGAVASGQPAGEASAPRPQPAAPAAAAPAVAASAAVTPPPPVQSEPAPQASPPPTPVQATEVAEATTDFVVPPVSVPRTEVNIVPRDTTPAVRERSVQTVQAPAVPMQVRQVPLAVPAPAVREVQVQEREVATLEAPVAPQPVRSADVQVRLPQQREVQVREREVQAVVDPQVRMAAVPGREPSVRAPTGREVQVRERSVANAPVAAPSPSTGASTAPAPAPAGSAARQSSTASARPAASSATPAQAGARPAPDPGNWATPAKGDDWGASDRNRDGARSGAAQASTQGAGQGLFNADGSVKVPGGEGEGEAERGAPGGANDGWTKERIAESGRWLKRPPYDYTPTSFDKYWVPQESLLAEWVRKGVKAMEIPLPGTSTKISCVISILQAGGGCGLTDPNMQDQPAVARPPPDIPFKKELQEDNGSR
>NZ_CP018756.1|WP_079222467.1|2523263_2523677_+|barstar-family-protein
MSHDDFGLGLHDINNAGVYAIDTGDISDLAAAMRDASLKVIRIDLHGVADKRTLLARLAAQLDFPAGFGGNWDALADNLRDLQWLPAPGYALFLADVDALRAGAAKDFDTLLDVMDEASRDWVGRDVPFWVFLSQSE
>NZ_CP018756.1|WP_079222466.1|2522805_2523267_+|ribonuclease
MRNPRLLITAIALLLLGLVANHFLQRPPAPQFAPDLQGAANRSAPAVHGSGGDRNDGLPGFLPAEARQTIALIQRGGPYPHRQDGTTFGNREQRLPQRPRGYYREYTVDTPGASNRGARRIITGGDPPQAWYYTDDHYDSFRSFTVPAPGERP
>NZ_CP018756.1|WP_079222465.1|2521971_2522583_-|superoxide-dismutase
MAYTLPKLSYAYDALEPNIDAATMEIHHTKHHQTYINNVNAALEGTEYADLPVEELVKKLKSLPENLQGPVRNNGGGHANHSLFWTVMAPNAGGNPVGDVAKAIDKDLGGFDKFKDAFTKAALTRFGSGWAWLSVTPDKKVVVESTGNQDSPLMEGNTPILGLDVWEHAYYLKYQNRRPEYIGAFFNVIDWNEVERRYQEAIA
>NZ_CP018756.1|WP_079222475.1|2533095_2533986_-|endonuclease/exonuclease/phosphatase-family-protein
MALKQGRARVALRGLGLAIALALPGLAPAQQAAEAVPAAAEVSAAPGMGMVTFNLHHDREDWPTRRRTILAELKRLQPDAIALQEVIQRRNVRNQAQWLASQLGYKYVFVSTDPVGAPKRYGNALLTRRPILAHGEHLLQPLDDYRTVAHLRIDVDGQPVNVYATHLNERSDERGQGIRRSQVEDLLRYITGTSAGAPVVIAGDFNALVDAGDLSELRSHYGDSYGSVHVNTDLAGVSTLNRHYYQAPSRIDHIFFQQDRMVAREAKILFDQPDDSGRFASDHYGVWTRLQFAPAR
>NZ_CP018756.1|WP_079222476.1|2533988_2537156_-|discoidin-domain-containing-protein
MKRAIAVGLGLLWTSLAIAAPPALPAPKVLDDFDDISAWKLVLSDQVSGSLRPVSGAGGGRALCLDYDFHKVSGYVGLRRALNIEYPANYRFGFQLRGDSPRNDLQFKLIDASGDNVWWVNRPGYSFSKAWAPVEYRRRQIDKAWGPSAEKEMARSAAVEFTIYSNVGGRGTVCFDKLTLQGLPPQDESALMPSVIADTATALQDRMIDGKSDTFWVSGGVKQQTISLDLHKSREIGGAVIDWLPNLEATRYTVRTSEDGRDWRTVREVTGGGGGRDWLALPDTDARYVRFDLQDGPNWRYGIRDIALKPLAFAATPNAFLSSVAADLPRGALPRAYVGEQPYWTLLGLDGGQEQALISEDGALEPAKGSFSIEPFIRMDGKLLDWSSVATTQSLQDRYLPIATVDWVHEKAGLSVTSFVQGTPERAQLIGRYRLSNPDKVAHEYTLALAIRPWQVNPPTQFLNTTGGFSRIEALDVGEQLVRVNGEPRIYPLQVPDARFATTFDGKLDAMHLASGSFPATTAVKDSTGLASGAMLYTIKLEPGQSREVAVVLPQTGGWKPQALDVAKAQQQVAAMWRDKLGVVNLQVPAAGQPLVETLRTAVAHMLISRVGPRLQPGTRSYARSWIRDGAMISEGLLRMGRSDAVRDYVTWYAPFQFENGKVPCCVDARGSDPVPENDSHGELIYNIAEYWRYTGDGTFLELMWPHVQGAYTYMEQLRASERTEENRARNPAFYGMMPASISHEGYSAKPMHSYWDNFWALRGYKDAAQVAAQLGKVEAMQISESRDQFRDDLQASLLAAMQQHRIDYLPGSAELGDFDATSTTVALAPGGEQGRLPQEALEATFERYWNEFVARRDGKREWKDYTPYEWRNVAAFVRLGWRDRAWQATQFFFKDRAPQPWNQWAEVVSRTPRKPFFVGDLPHAWVASDFVRSALDMFAYNRDADEALVLAAGIPTAWFQGEGIAVQGLRTPQGQLNYRLQRSDKQLVLELQAGLVPPPGGVVLPWPYSGDPGEATINGEPAEWNNRELRVHQLPARVEIDVPSAVRRAERKGQ
>NZ_CP018756.1|WP_079222477.1|2537152_2537989_-|carbohydrate-ABC-transporter-permease
MSREIGQSRWHPWMINGALLVLALVSLAPLLWMLSVSFMPQGEATHFPPPLLPSHVTTHNYTELFARTGMGGNFANSLLVSVAITFGSLLLNTMAGYAFAKLNFVGRERLFQVLMAALVIPAQVAMLPLFLLMKQLGLVNSFGGVIVPALASVFGIFLVRQYARSIPDELLEAARIDGAGELRIFFQIVLPMLKPVLVTLAIFTFMGAWNDFMWPLIVLTDQEHYTLPVALATLSREHIMDVEMMMAGAVVTVVPVLALFLVLQRYYIQGLLLGSVKG
>NZ_CP018756.1|WP_079222478.1|2537985_2538867_-|sugar-ABC-transporter-permease
MKRSSLAGWIFAGPSLIVLGVFFGLPVASALALSVTDFDLYALADGGNLRFVGLGNYVDLLQTPMFWKSLWNTTYFVVVGVPLSIGVSLGAAMLLNAPAARFKALFRTALFAPVVTTLVAVAVIWRYLFHTSYGLVNYGLGHIGISPIDWLGDPNWAMPTIMLFAVWKNFGYNMVIFLAGLQAIPHDLYEAARIDGASRWKQFLHITLPMLGPVLLVVGVITVSGYFQLFAEPYVMTRGDPLQSTVSVLYFMFEEGFKWWNLGRASAVAFLLFLIILAVTTVMLRFGRKRQLV
>NZ_CP018756.1|WP_079222479.1|2538863_2540204_-|sugar-ABC-transporter-substrate-binding-protein
MHDWIDRLRRWALPAMAALAMAGCARTEQGTTTVRFWAMGREAEVVSELIHEFEAENPGIKVDVQNIPWTAAHEKLLTAFAADGLPDVCQLGNTWVPEFAELNALTPLQPFVQQSSVVDPKDYFQGIWDTNVIHGELVGVPWYVDTRLIFYRKDLLAQAGFDHPPRTWAEWDEQMAAIKKMQGPNRYAVLMPINEFEQQLSLALQQPDPLLRDEDTRGNFSSPGFRRTLAFYANMFEQGWAPKMSETQISNVWDEFFRGFNVFYISGPWNIREFKKLQPKELEGKWGTAALPGPDGPGAGIAGGTSLVIFRKSQQKEASWKLIEFLSRPEIQARFHSIIGDLPPRRSTWNAPSLANDPLAAAFRDQLERVKPTPKVLEWERIVQEMRIVTEKVVRGGMPQDKAVEELDQRVDKVLAKRRWMHEQQRLQRSDAPPGSTSAVAAGSPQ
>NZ_CP018756.1|WP_079222480.1|2540208_2541813_-|hypothetical-protein
MQARHLLTAAAMTLAIAACKPAQQEPAKPKPPVILLEADAPPRPMKPELPPLFDDIERRTFQFFWDTTNELNGLTPDRYPSRPFASIASVGFALTAYPIGIENGWVSRNQAIDRTLTTLKFFRDVPMGPQRTGKAGYKGFYYHFLDMQEGRRYDSWVELSSVDTALLMMGVLFAQSYYDGDDPREKEIRQIADQLYKQVDWPWLQQRAPLISMGWFPESGFIDHDWMGYNEAMMVYILALGSPSHPVSPDAWTVWTRTYDNDWGVYQGQEYLSFGPLFGHQYSHVWIDFRDIQDAYMRERGSTYFLNSRSAALAHREYAIANPMQWKDYGENVWGLTASDGPQNTTQEYRGEQRQFRHYSSRGAGLRENFDDGTIAPTAAISSIVFAPEQVIPATLEMHKRYGDYIYSSYGFLDSFNPSFNYDIPIKTGRMVPDRGWVASDYIAIDQGPILTMIANYRDDFVWEVMKKNPYIRKGLERAGFSGGWLAPEGSFQPLVLEKDEKAAAARAVGIAESRAAAAQEQKNNANRNTGQGK
>NZ_CP018756.1|WP_079222481.1|2542061_2545121_-|TonB-dependent-receptor
MMHSTIRMPARRLLSTALVSCLMLAAAPNVMAQSANASLRGQVAGAQAGSEVTATNVATGTVRRGTVRADGTYSLMGLDPGTYDVAANGQTQKVTVTVASTSTLNFSEAAAGGTAGGSAATNLDTVNVVAPTLLQEVRTSEVGKTVSLQQIQTTPQVSRNFLEFADAVPGLIFTRDAKGNTSLRGGATNSDGTNVYIDGVGQKSYVKGGGVAGQSGSAGNPFPQLAIGEYKVISGNYKAEYGQVSSAAVTAATKSGTNEFKGEAFYRYTDEDMRAKTPAERQGGKDKMVSAEKEYGFALGGPIIQDKAHFFVTYEAKRFDLPVTIAPDGAVTGAASLLPPAGAAGLGPASQPFQQDLIFGKIDFEPTDNDRIELTFQDRDETQSQFSGQTSPEAGREVVNTDRRYALRWNHSGERFYNEMMVTHEDSFNNPTPLTLANGITYTAPDGTEDRTVVKIGGASALDSQVKGQKGWSIEDNLTLDGIQWAGDHTIKMGVKYKAIDLYASDAAQINPTFTYSLGDPDFPDSIPYKAQFVKPVTGVDGVSGEVRSKSKQYGVFIQDDWQVNDHLQINLGLRWDYEVTPSYLDFVTPQAVVDAIYSQDPRAPAGQTYADSLALGGLDISNYISNGHNRKAFKDAWQPRLGFSYDINADEQHVIHGGAGRSYDRDLFDNLQLETTKLALPQPTIYFRNPATGTCINGQAACYDWNPNLLNGIGNLQDLVGATSNAGLEVDLLNNKLKAPYSDQFSLGMSNQIGDWLTDATIARTLSYDGFAFTLGNRYPTGQFFDDPRLCGGTEAGLSQAWSCNVPGFGSLIIGQQGIKTRATQVLLSAQKPFTKESGWGTSIAYTWTTARHNRDINEKYAFDRGLIGDYPTIRSNGAPRHRLVMTGSYAGFWGITFGGKITLATPTAVNDWYPVPQASGFNLPTPQAAVPNANGKFLLGGKIFGYRSVDLQATKTFKMPGDTEMYARIDIINVFNFDNFSTYNYVKTNGKLQASYNETGDIIGTPRQVKAEVGFRF
>NZ_CP018756.1|WP_079222482.1|2545197_2546235_-|LacI-family-DNA-binding-transcriptional-regulator
MEGGFVNKAAITIKDVAREARVSVATVSRALNGHENVAEPVRQLVLEVAARLRYTPHAAARSLSSRRTNTVGVVLPDLYGEFFSELMRGIDNVARNRRQHLLVSSYHGDQVQQGAALRAMRGRVDGLLVLSPYAESPGFLTDNLPQSLPTVLINTYLPGQDHPVLSIDDHAGAMAMTRHLLDAGHRRIAFISGPDLNFDARERLRGFRDALAAFGNGAEGIELPGDFDEASGHRAGQEMLAAGALPDAVFAANDMMALGCLYAFAQAGIHVPTDVALAGFDDIPLARFVHPSLTTMQVSIAELGDRAMTRLMQLMDGNTPEGAGDKQTLVPRLIVRDSTTPPSGH
>NZ_CP018756.1|WP_079222483.1|2546383_2546659_-|BolA-family-transcriptional-regulator
MSAQRIDLIRAALQQALAPSTLEIEDDSHRHAGHAGARDGRGHFNVLVVSEQFAGMAPLARHRAVYAALGGLMETDIHALSIRAYTLSEQG
>NZ_CP018756.1|WP_079225292.1|2546655_2546955_-|YciI-family-protein
MFYVIEGYDGQDVLAQRLQARPEHLARLHALRDEGRLLLAGPCPAIDSEDPGPAGFSGSVVIAAFDSLAQARQWADADPYVAAGVYTRVDVRPFRKVLP

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Crispr_ID: NZ_CP018756_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_16

2550338-2550472

Orphan

Consensus_repeat	Method
GGAGGCGCCGGTGGTGGCCAGGGTCGTCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP018756_16

>merge|NZ_CP018756|16|2550338-2550472|PILER-CR
GGCGCTGGCGCGGGTGGCCAGGGCCGTCCGTACGGCAAGCCGAAGGGTCCGGGCGCAGGCGCCGGTGGCGGCCAGGGTCGCGGCGGCTTCGGCGGTGAAGGCCGTGGTGGCGCCGGTGGTGGCCAGGGTCGTCCG

>NZ_CP018756|16|1|2550338-2550472|PILER-CR
GGCGCTGGCGCGGGTGGCCAGGGCCGTCCG	TACGGCAAGCCGAAGGGTCCGGGC
GCAGGCGCCGGTGGCGGCCAGGGTCGCGGC	GGCTTCGGCGGTGAAGGCCGTGGTG
GCGCCGGTGGTGGCCAGGGTCGTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222493.1\|2555743_2555932_+\|heme-exporter-protein-CcmD	unknown	unknown	gnl\|CDD\|377440
NZ_CP018756.1\|WP_079222489.1\|2552261_2553410_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181642
NZ_CP018756.1\|WP_079222496.1\|2558318_2558936_+\|DsbE-family-thiol:disulfide-interchange-protein	unknown	unknown	gnl\|CDD\|239308
NZ_CP018756.1\|WP_079222481.1\|2542061_2545121_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379297
NZ_CP018756.1\|WP_079222492.1\|2554994_2555747_+\|cytochrome-c-biogenesis-protein-CcsA	unknown	unknown	gnl\|CDD\|273492
NZ_CP018756.1\|WP_079222477.1\|2537152_2537989_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP018756.1\|WP_079222494.1\|2555928_2556390_+\|cytochrome-c-maturation-protein-CcmE	unknown	unknown	gnl\|CDD\|237317
NZ_CP018756.1\|WP_079222488.1\|2551441_2552248_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|143599
NZ_CP018756.1\|WP_079222480.1\|2540208_2541813_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227662
NZ_CP018756.1\|WP_079222482.1\|2545197_2546235_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP018756.1\|WP_079222495.1\|2556390_2558310_+\|heme-lyase-CcmF/NrfE-family-subunit	unknown	unknown	gnl\|CDD\|224061
NZ_CP018756.1\|WP_079222478.1\|2537985_2538867_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP018756.1\|WP_079222491.1\|2554255_2554951_+\|heme-exporter-protein-CcmB	unknown	unknown	gnl\|CDD\|225260
NZ_CP018756.1\|WP_079225292.1\|2546655_2546955_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|183103
NZ_CP018756.1\|WP_079222490.1\|2553596_2554259_+\|heme-ABC-exporter-ATP-binding-protein-CcmA	unknown	unknown	gnl\|CDD\|184129
NZ_CP018756.1\|WP_079222479.1\|2538863_2540204_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP018756.1\|WP_079222483.1\|2546383_2546659_-\|BolA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376601
NZ_CP018756.1\|WP_079222487.1\|2550889_2551324_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222485.1\|2548245_2549124_+\|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl\|CDD\|224304
NZ_CP018756.1\|WP_079222484.1\|2547326_2548232_+\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|224273

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222493.1\|2555743_2555932_+\|heme-exporter-protein-CcmD	gnl\|CDD\|377440	pfam04995, CcmD, Heme exporter protein D (CcmD). The CcmD protein is part of a C-type cytochrome biogenesis operon. The exact function of this protein is uncertain. It has been proposed that CcmC, CcmD and CcmE interact directly with each other, establishing a cytoplasm to periplasm haem delivery pathway for cytochrome c maturation. These proteins contain a predicted transmembrane helix.	1.1235e-05
NZ_CP018756.1\|WP_079222489.1\|2552261_2553410_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181642	PRK09082, PRK09082, methionine aminotransferase; Validated.	0
NZ_CP018756.1\|WP_079222496.1\|2558318_2558936_+\|DsbE-family-thiol:disulfide-interchange-protein	gnl\|CDD\|239308	cd03010, TlpA_like_DsbE, TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c maturation (Ccm) factor with a redox active CXXC motif. Assembly of cytochrome c requires the ligation of heme to reduced thiols of the apocytochrome. In bacteria, this assembly occurs in the periplasm. The reductase activity of DsbE in the oxidizing environment of the periplasm is crucial in the maturation of cytochrome c.	8.82592e-68
NZ_CP018756.1\|WP_079222481.1\|2542061_2545121_-\|TonB-dependent-receptor	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	1.17725e-08
NZ_CP018756.1\|WP_079222492.1\|2554994_2555747_+\|cytochrome-c-biogenesis-protein-CcsA	gnl\|CDD\|273492	TIGR01191, Heme_exporter_protein_C, heme exporter protein CcmC. This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other].	1.68551e-64
NZ_CP018756.1\|WP_079222477.1\|2537152_2537989_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.21471e-88
NZ_CP018756.1\|WP_079222494.1\|2555928_2556390_+\|cytochrome-c-maturation-protein-CcmE	gnl\|CDD\|237317	PRK13254, PRK13254, cytochrome c maturation protein CcmE.	1.34626e-66
NZ_CP018756.1\|WP_079222488.1\|2551441_2552248_-\|amidohydrolase	gnl\|CDD\|143599	cd07575, Xc-1258_like, Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases). Uncharacterized subgroup belonging to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup either represents a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. XC1258 is a homotetramer.	6.95177e-147
NZ_CP018756.1\|WP_079222480.1\|2540208_2541813_-\|hypothetical-protein	gnl\|CDD\|227662	COG5368, COG5368, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP018756.1\|WP_079222482.1\|2545197_2546235_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.34002e-109
NZ_CP018756.1\|WP_079222495.1\|2556390_2558310_+\|heme-lyase-CcmF/NrfE-family-subunit	gnl\|CDD\|224061	COG1138, CcmF, Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP018756.1\|WP_079222478.1\|2537985_2538867_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.92799e-91
NZ_CP018756.1\|WP_079222491.1\|2554255_2554951_+\|heme-exporter-protein-CcmB	gnl\|CDD\|225260	COG2386, CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones].	1.34739e-52
NZ_CP018756.1\|WP_079225292.1\|2546655_2546955_-\|YciI-family-protein	gnl\|CDD\|183103	PRK11370, PRK11370, YciI family protein.	7.13771e-59
NZ_CP018756.1\|WP_079222490.1\|2553596_2554259_+\|heme-ABC-exporter-ATP-binding-protein-CcmA	gnl\|CDD\|184129	PRK13543, PRK13543, heme ABC exporter ATP-binding protein CcmA.	1.56157e-124
NZ_CP018756.1\|WP_079222479.1\|2538863_2540204_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.49751e-140
NZ_CP018756.1\|WP_079222483.1\|2546383_2546659_-\|BolA-family-transcriptional-regulator	gnl\|CDD\|376601	pfam01722, BolA, BolA-like protein. This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.	3.0768e-34
NZ_CP018756.1\|WP_079222485.1\|2548245_2549124_+\|SMC-Scp-complex-subunit-ScpB	gnl\|CDD\|224304	COG1386, scpB, Chromosome segregation and condensation protein B [DNA replication, recombination and repair].	6.08148e-63
NZ_CP018756.1\|WP_079222484.1\|2547326_2548232_+\|segregation/condensation-protein-A	gnl\|CDD\|224273	COG1354, scpA, Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair].	1.15998e-66

>NZ_CP018756.1|WP_079222485.1|2548245_2549124_+|SMC-Scp-complex-subunit-ScpB
MDQTLINRIVEGALLASSQPLTLAQLKDLFPEEEPAPPGSIERALERLREGCEGRGVELVEVASGFRYQVTGEVHGWISRLWTERKTRYTRATLETLALIAYRQPITRGEIEQVRGVAVSSNIIQALEEREWIRVVGHRDVPGKPALFGTTKGFLDYFGLKRLDELPPLSELKDLGELEPQLALDRDGPAVAGAAGPDISADPDAAANDDAGLQGGDGNTPDSADAAAAPATDEQAPSPLDDGHPDSAPGERAVPVNEREDNAVATTTVAVDQADSEPEADLETVGRSKTDE
>NZ_CP018756.1|WP_079222484.1|2547326_2548232_+|segregation/condensation-protein-A
MTSELALDANPPTRPPAPQQQEMPLAVVHGQPVLQIPQDLYIPPDALEVILDAFEGPLDLLLYLIRRQNLDVLDIPVAEITRQYVEYITVMRELRFELAAEYLVMAAILAEVKSRMLLPRPVSEEGDEADPRAELVRRLQEYERFKQAAEDIDALPRQDRDTTVAHAFMPERATVKLPPPVDLKEMLLALHDVLKRAELFSGHAIKREALSVRQRMGEVLGRLEDGRFYRFEGLFTAEEGKLGVLVTFLAVLELAKEQLLDLVQEEPLAPIYVKSLAAGNTNAPLQFSSEFDDNDAANENE
>NZ_CP018756.1|WP_079225292.1|2546655_2546955_-|YciI-family-protein
MFYVIEGYDGQDVLAQRLQARPEHLARLHALRDEGRLLLAGPCPAIDSEDPGPAGFSGSVVIAAFDSLAQARQWADADPYVAAGVYTRVDVRPFRKVLP
>NZ_CP018756.1|WP_079222483.1|2546383_2546659_-|BolA-family-transcriptional-regulator
MSAQRIDLIRAALQQALAPSTLEIEDDSHRHAGHAGARDGRGHFNVLVVSEQFAGMAPLARHRAVYAALGGLMETDIHALSIRAYTLSEQG
>NZ_CP018756.1|WP_079222482.1|2545197_2546235_-|LacI-family-DNA-binding-transcriptional-regulator
MEGGFVNKAAITIKDVAREARVSVATVSRALNGHENVAEPVRQLVLEVAARLRYTPHAAARSLSSRRTNTVGVVLPDLYGEFFSELMRGIDNVARNRRQHLLVSSYHGDQVQQGAALRAMRGRVDGLLVLSPYAESPGFLTDNLPQSLPTVLINTYLPGQDHPVLSIDDHAGAMAMTRHLLDAGHRRIAFISGPDLNFDARERLRGFRDALAAFGNGAEGIELPGDFDEASGHRAGQEMLAAGALPDAVFAANDMMALGCLYAFAQAGIHVPTDVALAGFDDIPLARFVHPSLTTMQVSIAELGDRAMTRLMQLMDGNTPEGAGDKQTLVPRLIVRDSTTPPSGH
>NZ_CP018756.1|WP_079222481.1|2542061_2545121_-|TonB-dependent-receptor
MMHSTIRMPARRLLSTALVSCLMLAAAPNVMAQSANASLRGQVAGAQAGSEVTATNVATGTVRRGTVRADGTYSLMGLDPGTYDVAANGQTQKVTVTVASTSTLNFSEAAAGGTAGGSAATNLDTVNVVAPTLLQEVRTSEVGKTVSLQQIQTTPQVSRNFLEFADAVPGLIFTRDAKGNTSLRGGATNSDGTNVYIDGVGQKSYVKGGGVAGQSGSAGNPFPQLAIGEYKVISGNYKAEYGQVSSAAVTAATKSGTNEFKGEAFYRYTDEDMRAKTPAERQGGKDKMVSAEKEYGFALGGPIIQDKAHFFVTYEAKRFDLPVTIAPDGAVTGAASLLPPAGAAGLGPASQPFQQDLIFGKIDFEPTDNDRIELTFQDRDETQSQFSGQTSPEAGREVVNTDRRYALRWNHSGERFYNEMMVTHEDSFNNPTPLTLANGITYTAPDGTEDRTVVKIGGASALDSQVKGQKGWSIEDNLTLDGIQWAGDHTIKMGVKYKAIDLYASDAAQINPTFTYSLGDPDFPDSIPYKAQFVKPVTGVDGVSGEVRSKSKQYGVFIQDDWQVNDHLQINLGLRWDYEVTPSYLDFVTPQAVVDAIYSQDPRAPAGQTYADSLALGGLDISNYISNGHNRKAFKDAWQPRLGFSYDINADEQHVIHGGAGRSYDRDLFDNLQLETTKLALPQPTIYFRNPATGTCINGQAACYDWNPNLLNGIGNLQDLVGATSNAGLEVDLLNNKLKAPYSDQFSLGMSNQIGDWLTDATIARTLSYDGFAFTLGNRYPTGQFFDDPRLCGGTEAGLSQAWSCNVPGFGSLIIGQQGIKTRATQVLLSAQKPFTKESGWGTSIAYTWTTARHNRDINEKYAFDRGLIGDYPTIRSNGAPRHRLVMTGSYAGFWGITFGGKITLATPTAVNDWYPVPQASGFNLPTPQAAVPNANGKFLLGGKIFGYRSVDLQATKTFKMPGDTEMYARIDIINVFNFDNFSTYNYVKTNGKLQASYNETGDIIGTPRQVKAEVGFRF
>NZ_CP018756.1|WP_079222480.1|2540208_2541813_-|hypothetical-protein
MQARHLLTAAAMTLAIAACKPAQQEPAKPKPPVILLEADAPPRPMKPELPPLFDDIERRTFQFFWDTTNELNGLTPDRYPSRPFASIASVGFALTAYPIGIENGWVSRNQAIDRTLTTLKFFRDVPMGPQRTGKAGYKGFYYHFLDMQEGRRYDSWVELSSVDTALLMMGVLFAQSYYDGDDPREKEIRQIADQLYKQVDWPWLQQRAPLISMGWFPESGFIDHDWMGYNEAMMVYILALGSPSHPVSPDAWTVWTRTYDNDWGVYQGQEYLSFGPLFGHQYSHVWIDFRDIQDAYMRERGSTYFLNSRSAALAHREYAIANPMQWKDYGENVWGLTASDGPQNTTQEYRGEQRQFRHYSSRGAGLRENFDDGTIAPTAAISSIVFAPEQVIPATLEMHKRYGDYIYSSYGFLDSFNPSFNYDIPIKTGRMVPDRGWVASDYIAIDQGPILTMIANYRDDFVWEVMKKNPYIRKGLERAGFSGGWLAPEGSFQPLVLEKDEKAAAARAVGIAESRAAAAQEQKNNANRNTGQGK
>NZ_CP018756.1|WP_079222479.1|2538863_2540204_-|sugar-ABC-transporter-substrate-binding-protein
MHDWIDRLRRWALPAMAALAMAGCARTEQGTTTVRFWAMGREAEVVSELIHEFEAENPGIKVDVQNIPWTAAHEKLLTAFAADGLPDVCQLGNTWVPEFAELNALTPLQPFVQQSSVVDPKDYFQGIWDTNVIHGELVGVPWYVDTRLIFYRKDLLAQAGFDHPPRTWAEWDEQMAAIKKMQGPNRYAVLMPINEFEQQLSLALQQPDPLLRDEDTRGNFSSPGFRRTLAFYANMFEQGWAPKMSETQISNVWDEFFRGFNVFYISGPWNIREFKKLQPKELEGKWGTAALPGPDGPGAGIAGGTSLVIFRKSQQKEASWKLIEFLSRPEIQARFHSIIGDLPPRRSTWNAPSLANDPLAAAFRDQLERVKPTPKVLEWERIVQEMRIVTEKVVRGGMPQDKAVEELDQRVDKVLAKRRWMHEQQRLQRSDAPPGSTSAVAAGSPQ
>NZ_CP018756.1|WP_079222478.1|2537985_2538867_-|sugar-ABC-transporter-permease
MKRSSLAGWIFAGPSLIVLGVFFGLPVASALALSVTDFDLYALADGGNLRFVGLGNYVDLLQTPMFWKSLWNTTYFVVVGVPLSIGVSLGAAMLLNAPAARFKALFRTALFAPVVTTLVAVAVIWRYLFHTSYGLVNYGLGHIGISPIDWLGDPNWAMPTIMLFAVWKNFGYNMVIFLAGLQAIPHDLYEAARIDGASRWKQFLHITLPMLGPVLLVVGVITVSGYFQLFAEPYVMTRGDPLQSTVSVLYFMFEEGFKWWNLGRASAVAFLLFLIILAVTTVMLRFGRKRQLV
>NZ_CP018756.1|WP_079222477.1|2537152_2537989_-|carbohydrate-ABC-transporter-permease
MSREIGQSRWHPWMINGALLVLALVSLAPLLWMLSVSFMPQGEATHFPPPLLPSHVTTHNYTELFARTGMGGNFANSLLVSVAITFGSLLLNTMAGYAFAKLNFVGRERLFQVLMAALVIPAQVAMLPLFLLMKQLGLVNSFGGVIVPALASVFGIFLVRQYARSIPDELLEAARIDGAGELRIFFQIVLPMLKPVLVTLAIFTFMGAWNDFMWPLIVLTDQEHYTLPVALATLSREHIMDVEMMMAGAVVTVVPVLALFLVLQRYYIQGLLLGSVKG
>NZ_CP018756.1|WP_079222487.1|2550889_2551324_-|hypothetical-protein
MNKPLVLLLALAAASLAPAAHAGGNLDCQLRYNLSGWSLIYKTASGNGTIQCSNGASMPVHIQLKGGGLTVGKSKISNGRGSFTGAVGINELLGTYASVGAHAGAVKSSNAQVMTKGDVSLALSGTGKGWDLGVDGTAFTISRR
>NZ_CP018756.1|WP_079222488.1|2551441_2552248_-|amidohydrolase
MQDLRISLVQGDTRWHDPAGNRDYYGALLAPLAGGTDLVILPETFTSGFSNEAIAQAEGMDGPTVAWVREQAKALGAAVIGSVQLRDGEGVYNRLLFATPDGGLQYYDKRHLFRYGGEHERYAAGRDRLSVEWKGWRINPQVCYDLRFPVFCRNRYNVERAGQMDFDLQIFVANWPSARAYAWKTLLRARAIENLCFVAAVNRIGVDGNQLHYAGDSAVIDFLGQPQVEIREREQVVTTTISAEALAAHRARFPAMLDADAFHLDERA
>NZ_CP018756.1|WP_079222489.1|2552261_2553410_-|pyridoxal-phosphate-dependent-aminotransferase
MQPTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFSAPQRLIDETTKAMAAGLNQYPPMTGVAPLRQAIAQKSLDLYGATIDPDTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIELAGAIAVHVPLDPQTFAVDWDRVRAAITPRTRMLMVNTPHNPSGAMLDEADMQALADLLRGTQIYLISDEVYEHIIYDGRRHESALRYPELRERTFVISSFGKTYHCTGWKIGYAVAPPLLTAEFRKVHQYNTFTSFGPAQYGFAAMIRDEPEHHLELGAFYQAKRDRFREQLASTRLKPLPVPGGYFQLVDYSAISDLPDHEFVKWLTIEKGVTAIPLSPFYETAPVGQRLVRLCFAKNEATLDAAIERLRLL
>NZ_CP018756.1|WP_079222490.1|2553596_2554259_+|heme-ABC-exporter-ATP-binding-protein-CcmA
MNTPALLAASGLSFSRNDEPVFGPLDFHVDAGEALLVQGGNGAGKTTLLRVLAGLARPGAGQVRIDGKQASNAERARYVAYLSHLPALKPDLDTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDTLVRHLSAGQKRRLALARIWLSPAPLWLLDEPYANLDLDGINLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRLLELRAPGQPPATTQGAAA
>NZ_CP018756.1|WP_079222491.1|2554255_2554951_+|heme-exporter-protein-CcmB
MIAPGTEPGLWQTARALLSRDLRLLWRRRGDALQPVLFALLVVVLFALAQGRDPQPLAATAGAVLWLAVLLAGQLALDSLFRSDAEDGSLEQWLLAPVPLAWLVLVRVLLHWATTALPLIVVSPLLAEMLHLPHDQLPMLLASLLLGTPVLSLIGGVVAALTVGIRRSGILVALLSLPLYVPVLVFGAGSLAAASRGQDPVGALLMLGAGLVVALLLAPLATAAAIRISLS
>NZ_CP018756.1|WP_079222492.1|2554994_2555747_+|cytochrome-c-biogenesis-protein-CcsA
MNPIVRWFHQLGSPPTFDRFAARWSRVFYIAALPVLLVGLWQALLVVPPEARQLDSFRILYIHVPSAWMSLFVFALMALYAAIALIWRIKICEILAMACAPMGAGFTLITLLTGSIWGKGTWGTWWDWDPRMTSELVLLFLYLGVIGLYHAIEDRRSAARAAGLLAIVGVSLLPVIRYSVDWWGGLHQRQSISVFGDSAISSAMIAPLWWMVIGTKFWFAGSVLAKARADNLDREAGKAWVGQRVEETQR
>NZ_CP018756.1|WP_079222493.1|2555743_2555932_+|heme-exporter-protein-CcmD
MTHLPFVIGAYAVFVLVLLADAIGSWMRLRAARRQAQSRQQRQQARQTAQQAAPTLSAELER
>NZ_CP018756.1|WP_079222494.1|2555928_2556390_+|cytochrome-c-maturation-protein-CcmE
MTPVQRRRLAWVLLALLASGLATALVAMALERNIAYLYTPSEVLRGDVDAQTRFRLGGMVVKGSFNRPVGSLDARFEVTDGDAQLAVLTSRILPDMFAEGTAVVASGRLQDGVFVADEVLAKHDEKYVPKEVADKMGDAHRKHDVPVPATEVR
>NZ_CP018756.1|WP_079222495.1|2556390_2558310_+|heme-lyase-CcmF/NrfE-family-subunit
MLPELGQILLLCALLASLLQAGLPLVGAQRGNAAWMAVARPAACAQLLLVAGAFAVLTAAFVQQDFSVRYVAENSNSLLPMIYRYSAVWGAHEGSLLMWALVLALWTGAVALFSRHLPAPVQARVLAVMGVVSVGFLAFLIFTSNPFLRLNPAPLEGRDLNPLLQDPGLIIHPPMLYLGYVGFAVPFAFAVAALLEGRVDARWLRWTRPWTNVAWGFLTLGIALGSWWAYYELGWGGWWFWDPVENASFMPWLVGAALIHSQAATEKRGTFGSWTLLLAIAAFALSLLGTFLVRSGVLTSVHSFAADPSRGLFILVFLSLLVGGSLLLYVLRASGLSVDAGDPRRGFTATSRETLLLANNLLLATACAMVLLGTLYPLLADALSLGKISVGPPYFGSLFLLLMAPMVLLLPFGPLVKWQRDQPSRAFALLAPWLGLAVLLGALAWWQAPQNGWKAGLGVAAAAWVGLGTARFVWQRLRGNGRFTAEMLGMIVAHAGIAVFLAGALLVEALNVQREVALAPGQQVVVGRHEVRFEGVDHREGPNFTADRGHLRVFRNGRELALLHPEKRQYASGGQVMTEAGIDARLSGDVYVALGEPLGNNAWAVRVHIKPFVRWIWLGALLMALGGFITAADRRFRRP
>NZ_CP018756.1|WP_079222496.1|2558318_2558936_+|DsbE-family-thiol:disulfide-interchange-protein
MSESPAPRPSRPLPPVAIVIGVLFFFGLLGLMIYGVMKSGDPQRDVLPSALIDKPAPAFALPVLHDPSMTVRSEELRGAPYLLNVWGSWCAACREEHPVLTRFAESKRVRVIGYNWKDEPTDALHWLETLGNPFMVVLSDVEGRTAIDWGVTAAPETFLVDGSGIVRWKYSGAMTQQVVDEKLIPALQKIEKAQGNADAGLHGNP

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Crispr_ID: NZ_CP018756_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_17

2626197-2626327

orTypeII

Consensus_repeat	Method
TGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_17

>merge|NZ_CP018756|17|2626197-2626327|CRISPRCasFinder
TGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATCGAATGAATTCATCCACGCATGGCGTGGATCTACTGGCAACTGCGGCTGTTGGTAGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATC

>NZ_CP018756|17|16|2626197-2626327|CRISPRCasFinder
TGGTGGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATC	GAATGAATTCATCCACGCATGGCGTGGATCTACTGGCAACTGCGGCTGT
TGGTAGGTGCCGACCGTTGGTCGGCACATCTGTCAGATATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222544.1\|2615941_2616886_-\|TraB/GumN-family-protein	unknown	unknown	gnl\|CDD\|350614
NZ_CP018756.1\|WP_152027103.1\|2631191_2632325_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222542.1\|2614286_2615027_+\|acetoacetyl-CoA-reductase	unknown	unknown	gnl\|CDD\|273823
NZ_CP018756.1\|WP_079222553.1\|2627586_2629458_-\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|335469
NZ_CP018756.1\|WP_079222554.1\|2629542_2630622_+\|ribonuclease-D	unknown	unknown	gnl\|CDD\|130455
NZ_CP018756.1\|WP_079222547.1\|2619891_2621460_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|223929
NZ_CP018756.1\|WP_079222559.1\|2638235_2639126_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222551.1\|2624644_2625976_+\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|234714
NZ_CP018756.1\|WP_079222552.1\|2626600_2627497_-\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320690
NZ_CP018756.1\|WP_079222556.1\|2632452_2634780_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP018756.1\|WP_079222557.1\|2634968_2637527_-\|Cache-3/Cache-2-fusion-domain-containing-protein	unknown	unknown	gnl\|CDD\|185001
NZ_CP018756.1\|WP_079222550.1\|2623528_2624599_+\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
NZ_CP018756.1\|WP_079222545.1\|2616888_2617818_-\|DUF1684-domain-containing-protein	unknown	unknown	gnl\|CDD\|225894
NZ_CP018756.1\|WP_079222543.1\|2615211_2615745_+\|polyhydroxyalkanoate-synthesis-repressor-PhaR	unknown	unknown	gnl\|CDD\|130907
NZ_CP018756.1\|WP_079222548.1\|2621541_2622024_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|223873
NZ_CP018756.1\|WP_079222546.1\|2617843_2619751_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NZ_CP018756.1\|WP_174208691.1\|2639153_2639330_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222549.1\|2622020_2623505_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|182554
NZ_CP018756.1\|WP_079222560.1\|2639440_2640202_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222558.1\|2637648_2637954_-\|Rho-binding-antiterminator	unknown	unknown	gnl\|CDD\|369197

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222544.1\|2615941_2616886_-\|TraB/GumN-family-protein	gnl\|CDD\|350614	cd14789, Tiki, Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues. Tiki is a membrane-associated metalloprotease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. Wnt is essential in animal development and homeostasis. In xenopus, tiki is critical in head development. In human cells, TIKI inhibits Wnt-signaling, which is important in embryogenesis, homeostasis, and regeneration. Deregulation of WNT contributes to birth defects, cancer and various diseases. TIKI homology domains are part of the TraB family and are related to the Erythromycin esterase, GumN plant pathogens, RtxA toxins, and Campylobacter Jejuni heme-binding, Chan-like proteins. TraB/PrgY are identified in gut bacterium Enterococcus faecalis, but its function has not been well characterized. Plasmid-borne, TraB has been implicated in the regulation of pheromone sensitivity and specificity. Based on homology to TIKI activity, it has been proposed that TraB acts as a metalloprotease in the inactivation of mating pheromone. The TIKI/TraB family has 2 conserved GxxH motifs and conserved glutamate and arginine residues that may be catalytic.	2.36573e-83
NZ_CP018756.1\|WP_079222542.1\|2614286_2615027_+\|acetoacetyl-CoA-reductase	gnl\|CDD\|273823	TIGR01829, Acetoacetyl-CoA_reductase, acetoacetyl-CoA reductase. This model represent acetoacetyl-CoA reductase, a member of the family short-chain-alcohol dehydrogenases. Note that, despite the precision implied by the enzyme name, the reaction of EC 1.1.1.36 is defined more generally as (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH. Members of this family may act in the biosynthesis of poly-beta-hydroxybutyrate (e.g. Rhizobium meliloti) and related poly-beta-hydroxyalkanoates. Note that the member of this family from Azospirillum brasilense, designated NodG, appears to lack acetoacetyl-CoA reductase activity and to act instead in the production of nodulation factor. This family is downgraded to subfamily for this NodG. Other proteins designated NodG, as from Rhizobium, belong to related but distinct protein families.	2.8684e-142
NZ_CP018756.1\|WP_079222553.1\|2627586_2629458_-\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	3.54752e-69
NZ_CP018756.1\|WP_079222554.1\|2629542_2630622_+\|ribonuclease-D	gnl\|CDD\|130455	TIGR01388, Ribonuclease_D, ribonuclease D. This model describes ribonuclease D, a 3'-exonuclease shown to act on tRNA both in vitro and when overexpressed in vivo. Trusted members of this family are restricted to the Proteobacteria; Aquifex, Mycobacterial, and eukaryotic homologs are not full-length homologs. Ribonuclease D is not essential in E. coli and is deleterious when overexpressed. Its precise biological role is still unknown. [Transcription, RNA processing].	1.17418e-113
NZ_CP018756.1\|WP_079222547.1\|2619891_2621460_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	7.37126e-66
NZ_CP018756.1\|WP_079222551.1\|2624644_2625976_+\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|234714	PRK00286, xseA, exodeoxyribonuclease VII large subunit; Reviewed.	0
NZ_CP018756.1\|WP_079222552.1\|2626600_2627497_-\|M48-family-metallopeptidase	gnl\|CDD\|320690	cd07331, M48C_Oma1_like, Peptidase M48C, integral membrane endopeptidase. This subfamily contains peptidase M48C Oma1 (also called mitochondrial metalloendopeptidase OMA1) protease homologs that are mostly uncharacterized. Oma1 is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins; it cleaves a misfolded polytopic membrane protein at multiple sites. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Oma1 is part of highly conserved mitochondrial metallopeptidases, with homologs present in higher eukaryotes, eubacteria and archaebacteria, all containing the zinc binding motif (HEXXH). It forms a high molecular mass complex in the inner membrane, possibly a homo-hexamer.	6.47985e-87
NZ_CP018756.1\|WP_079222556.1\|2632452_2634780_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	2.05968e-44
NZ_CP018756.1\|WP_079222557.1\|2634968_2637527_-\|Cache-3/Cache-2-fusion-domain-containing-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	2.5146e-79
NZ_CP018756.1\|WP_079222550.1\|2623528_2624599_+\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	0
NZ_CP018756.1\|WP_079222545.1\|2616888_2617818_-\|DUF1684-domain-containing-protein	gnl\|CDD\|225894	COG3358, COG3358, Uncharacterized conserved protein [Function unknown].	2.9715e-72
NZ_CP018756.1\|WP_079222543.1\|2615211_2615745_+\|polyhydroxyalkanoate-synthesis-repressor-PhaR	gnl\|CDD\|130907	TIGR01848, Uncharacterized_protein_Alvin_0064, polyhydroxyalkanoate synthesis repressor PhaR. Poly-B-hydroxyalkanoates are lipidlike carbon/energy storage polymers found in granular inclusions. PhaR is a regulatory protein found in general near other proteins associated with polyhydroxyalkanoate (PHA) granule biosynthesis and utilization. It is found to be a DNA-binding homotetramer that is also capable of binding short chain hydroxyalkanoic acids and PHA granules. PhaR may regulate the expression of itself, of the phasins that coat granules, and of enzymes that direct carbon flux into polymers stored in granules. The C-terminal region is poorly conserved in this family and is not part of this model.//GO terms added 12/6/04 [SS] [Fatty acid and phospholipid metabolism, Biosynthesis, Regulatory functions, DNA interactions].	8.13137e-62
NZ_CP018756.1\|WP_079222548.1\|2621541_2622024_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|223873	COG0802, COG0802, Predicted ATPase or kinase [General function prediction only].	1.27157e-44
NZ_CP018756.1\|WP_079222546.1\|2617843_2619751_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NZ_CP018756.1\|WP_079222549.1\|2622020_2623505_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|182554	PRK10565, PRK10565, putative carbohydrate kinase; Provisional.	3.06593e-150
NZ_CP018756.1\|WP_079222558.1\|2637648_2637954_-\|Rho-binding-antiterminator	gnl\|CDD\|369197	pfam07073, ROF, Modulator of Rho-dependent transcription termination (ROF). This family consists of several bacterial modulator of Rho-dependent transcription termination (ROF) proteins. ROF binds transcription termination factor Rho and inhibits Rho-dependent termination in vivo.	1.20791e-22

>NZ_CP018756.1|WP_079222551.1|2624644_2625976_+|exodeoxyribonuclease-VII-large-subunit
MQPRNNDVLTPSQLNTLARDLLEGSFPAIWVEAELGSVARPASGHLYFTLKDARAQLRAAMFRMKAQYLKFVPREGMRVLVRGKVTLYDARGEYQMVLDHMEEAGEGALRRAFEELKARLEAEGLFDPARKRPMPAHVQRLAVITSPTGAAVRDVLSVLARRFPLLEVDLLPTLVQGSTAAAQITRLLQAADASGRYDVILLTRGGGSLEDLWAFNDEALARAIAASGTPVVSAVGHETDFSLSDYAADLRAPTPSVAAELLVPDQRELTLRLRRTAARMVQLQRHTMQQAMQRADRALLRLNAQSPQARLDLLRRRQLDLGRRLHAAFNQQQERRAARLRHAAAILRGHHPQRQLDEMQRRLAALRGRPQAALQRLLQRDALRLRGLARSLEAVSPLATVARGYSILTRRDDGTLVRQVGQVQPGDALQARVGDGVIDVLVK
>NZ_CP018756.1|WP_079222550.1|2623528_2624599_+|tRNA-epoxyqueuosine(34)-reductase-QueG
MFPVPAPLDPAQAVSRIRELARAHGFQRCGIAGIELGEDEAHLADWLGKGLYGTMDWMARHGTLRARPAELLPGTVRVISVGMDYSHKDDTEAWATLADPGRAYVARYALGRDYHKLMRNRLQKLATQINDEVAPLGYRVFVDSAPVLERALARNAGLGWIGKHTCLIDRHGGSWFFIGEIYIDIPLPIDAPATAHCGTCTRCIDICPTQAIIGPQRLDARRCISYLTIEHDGAIPEDMRPLMGNRIYGCDDCQLVCPWNKFAKRTDEADFRARNNLDTARLDQLFAWDEAEFLRRTEGSPIRRSGHERWLRNIAVALGNAPASAEALAALHTRIDDPSPLVREHVQWALAQHGAR
>NZ_CP018756.1|WP_079222549.1|2622020_2623505_-|NAD(P)H-hydrate-dehydratase
MPDLSLLFDTAAARTLDARASALAGDDGWGLMSQAGLAAWQCLLQQWPDARQLCVVAGSGNNGGDGYVLATHALQSGRQVRLFVLAGKPPATALARQAAAAFIDAGGQVETVDGALPACDLLVDALFGLGLDRAPEGDARALIEAINAQDAPVFALDVPSGVDADRGQVPGVAVRAQVTLQFIANHRGLFTGGALDHVGQRRLAPLELDDASWEGVSASAQRWAADRLPRLLPPRRANTHKGESGHVLCVGGNHGSGGAIALAAEAGLRAGAGLLSIGTRGDHVGPLLARLPEAMVHALEDGDVLPNLLDKARVVAIGPGLGQDDWARALFARVLDCGKPLVIDADALNLLARDPRALPDAILTPHPGEAARLLECTTAEIQADRYRCAQALAERYHAVVVLKGAGSIVAAPGQTPRLIAAGNPGMAVGGMGDLLTGIIASLRAQGLDAFDAAACGALLHALAGDAAALDGARGLLPTDLLAPLRRLANPELPQ
>NZ_CP018756.1|WP_079222548.1|2621541_2622024_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MTEFFLADSEATELLGQWLAATRPPQALVELRGDLGAGKSTTARALLRASGVQGAIRSPTYTLVERYPLASGGEAWHLDLYRIGQAGELDFLGLDEGSAVLWLVEWPERGAGALPPTDLVVALEIEGQGRRVRLTGASDAGREWLGRLPDGGDLQAISVG
>NZ_CP018756.1|WP_079222547.1|2619891_2621460_-|N-acetylmuramoyl-L-alanine-amidase
MRLGNRLIAICAAVGLGLASVCAWAGEVRQVQLNTGATGTRAEISLVGSGGYKTLSLSSPNRLVIDFPDSSAVHNLKMPAAQGVVTAVRTGQPVPGTFRVVFDLAASVAPFRPQMQREGNESRLVIEWPGDGPATAASRAAPAAAAPVAPSTASTAAAQTAQSRGDAARATALLTAQVQQQASATAAAPVAPAPAPTTTPAQVAAAGISAGSTPPPPSSSSPAAILAGQPTRTVVAAAPAPTPAPAAAPAEAPRPAMPSDASRIRMQPGMRHLVVAIDPGHGGQDPGAIGPTGKREKDVTLAVARELARQVNATPGLKAYLTRDSDVFIPLPMRAQKARANKADIFISIHADAAENRSATGSSVYVLSTKGASSQRARWLADKENAADLVGGVRLQQTEGTLANVLLDLAQSGYMKASEDAAGHVLGGLKRIGNNHKPNLERANFAVLRTSDMPAMLVETAFISNPDEERRLIDPAYQRKVAGAVLDGVHTFFSRQPPPGTLYAARAQAEIDAAATMAGGSK
>NZ_CP018756.1|WP_079222546.1|2617843_2619751_-|DNA-mismatch-repair-endonuclease-MutL
MTSATHPRPIRPLPEILINQIAAGEVVERPASVVKELVENAIDAGASRVDIDLEEGGVRLIRIRDNGSGIAPEQLPLAVSRHATSKIADLDDLESVATLGFRGEALPSIASVSRFTLASRRAHDEHGSALQIEGGKIGEVTPRAHAPGTTVEVRELFYNVPARRKFLRAERTEMGHIEEWLRSLALARPDVELRVSHNGKASRRYKPGDLYSDARLAETLGEDFANQAVRVDHTGAGLRLHGWIAQPHYSRASADQQYLYVNGRSVRDRSVAHAVKMAYGDVLYHGRQPAYVLFLELDPTRVDVNVHPAKHEVRFRDSRLVHDFVYRTLKDALADTRAGVSAQEIGAGPAHPADAGSAPMPSSAGASGFGLVRGAAPGSGGGGGGGGFSGWRPQQPLGLQVADAPAAYAALYAAPGAGERSSALPPMPSENGLPVTSADAGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKNAHDGIGLQSQPLLVPITLAVGEREADTAEAEAETLSALGFEVTRAGPGALHVRSIPALLANAEPEGLLRDVLTDLREHGQSRRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEITERSGQCNHGRPTWARFSLAEIDRWFLRGR
>NZ_CP018756.1|WP_079222545.1|2616888_2617818_-|DUF1684-domain-containing-protein
MRYRGVGGLLVALLLAACSPSPEPVAVVKEDPAFAAAQQQWRVQRYEDLTRPDGWTALVGLHWLQYKSHFIGSGASSGIRLGVGPDKLGLLRREGDQWWFSPEAGVDVSQDGQPVRGRVRMNTDKDPAPTVLAFDGGKGHLSIIRRGPRDALRVKHADAAARRDFAGLQYWPGGAGWQVQARFIAHPAGKTLPIVDITGLTTEMPNAGAVEFERDGRSWRLEAIGAPGEPLFLVFADRTSGHGSYPAGRYLDIDAPAADGSVRIDFNHAYNPPCAFTPYATCPLAPPENRLDLRVDAGEKAYHLPEGEG
>NZ_CP018756.1|WP_079222544.1|2615941_2616886_-|TraB/GumN-family-protein
MSIRSLLRGAVLLLACAVAPLAAARGAPAEAPAAKPPVPLLWKVTGPGDARVYLLGSFHLLKPTDYPLSADVEQAFTASKRVLFEVSPEEMESTQAATQMVQTAIRRDGSELKRDLDDATWQKLQAYATQNKLPLAQLQGMKSWFVALNITIGQMQKMGLDANLGLDRYFMAQAKKAGKQTGGLEDMQSQINLLDGMSLQEQRQMMAEALDQAEKGDAQSLMLHDAWRRGDDRLLWNKMAVEMRQQYPQLYQRINTARNDAWVPKLLPYLQDGQGGTLVVVGGLHLLGSDGVVEKLKAKGYKVERVCTGCKPKR
>NZ_CP018756.1|WP_079222543.1|2615211_2615745_+|polyhydroxyalkanoate-synthesis-repressor-PhaR
MAATRIIKKYPNRRLYDTEISSYITIEDVRQLILDGEDFEVRDAKSGDDLTRSVLLQIIADQEQDGEPMLSTQLLSQLIRFYGDSLQGFMGNYLERSMQVFLDQQQQFRQQMGNLLGQTPWAMMNQLTERNLELWQEFQRNMGTGFGGPRPGGTGTGTGTKPNEPGTGTGTGGKTRR
>NZ_CP018756.1|WP_079222542.1|2614286_2615027_+|acetoacetyl-CoA-reductase
MTSRVALVTGGTGGIGTAICQRLADQGHRVATNYRDEAKARAWQQAMTERGYNVSIFPGDVSDPDSAEALIRAVEAELGPVEILVNNAGITRDTTFHRMRADQWHDVINTNLNSVFNVTRPVIEGMRRRGWGRVIQISSINGLKGQYGQANYAAAKAGMHGFTISLARENAGFGITVNTISPGYVATDMVMAVPEEVRAKIIADIPTGRLGKPEEIAYGVSFLVADEAAWITGSNLDINGGHHMGW
>NZ_CP018756.1|WP_079222552.1|2626600_2627497_-|M48-family-metallopeptidase
MRNDPFSRSPQQGPRRGLFGNIRWWVLLLAAGYAAFYWFSNRSVDPYTGEKVLIDSTLDASQEKALGLQAYQEILSQERPLDPNAQISRDIRAIAQRLIAKVDVVETALAQEHGVQPGHFSRDFDWEVNVIQSDQANAFCLPGGKMAVYTGLVPVARTTDAMAVVMGHEIAHALLRHGAQRMAQQKLTQIGQMAGAASGMDAQQQQMMMSAMGYGYLLPYARSHETQADEVGLMLAAAACFDPREAVPLWERMGQASGGQSPPEFSSTHPNPGTRIQNLQALMPKALEYRQKFCEQAK
>NZ_CP018756.1|WP_079222553.1|2627586_2629458_-|formylglycine-generating-enzyme-family-protein
MRFPLSSALCTALAVALAGCTPPPPVPASGADEERPAQAQPADAPGQGTVTIADDDAAEDIQQWTPPRVDRQQRSQAQLRRAAGQAFARDHLYEDADAAIPLWLAVQEEDPDDRQARDGLQRARQRLLQQADALLARPLKQREALAEASRQALVLLTLAPKDDKVRALQGRVETAQRVVAYNRAGEDDLRADRIGEDGDGAIPNFREALALDKDNRRARQGLAAAESGLIRRAEDAARARDFASAGTWLAEASKVRDSSPTIADAFERIEQIRATALVQLRDGGLRDLTTPQGLKPAREKLAEALRIALPGDPVVAQLRERIDLATHYGSFRPGQVFSDALRDGGRGPQMIVVPHGGFQMGAGDTEPGATDAERPSHYVRFERGFAMAITEVTVSDFERYVKATNARPRATRRGHSVVYDERSGNFIRRSGVDWRSDYDGSRAMGNSPVMHVSVRDAENYATWLSEQTGRSYRLPSEAEFEYAMRGGNSGRYPWGDAGLPPEGNGNYTGSRDVSPSGRHWQNAFVGYGDGWWGPAPVATFQANAFGLHDLSGNLSEWVADCWHASYRRAPSDGAAWFNPGCRSRVIRGGNWANAPEQTRAAWRQSQDSDTTSARIGFRLVRGI
>NZ_CP018756.1|WP_079222554.1|2629542_2630622_+|ribonuclease-D
MATWITTPAELDTYRQQRPSRIGLDTEFIRERTFWPQLALVQMAVGDDILLIDPLIPGMPEALAPWLADESITKVMHSASEDLVAFKWTCGVLPRPLFDTQIGAALAGIGAGMGYQKLVQEITGVALAKGETRSDWMRRPLSDSQLQYAADDVEHLFALHDAIDGKLQALGRQQWLHDDGERLLASVANDEDRWPHLGMRAAQFLDAAAQRRLLRLLRWRDVQARSSDRPRSWILDNELAATLARTPPADEAALGKLFEQFPKAPRKLAGAVWQALSTPLDDEADAPLAMQASDTNKQLLKKLQDAVAERSRELGLADGVLASRKHLESYLERRQWPAALAGWRQQELEARLQALLPAR
>NZ_CP018756.1|WP_152027103.1|2631191_2632325_-|hypothetical-protein
MLKSLYQDHADPITALALQARCEAQVVSWRWATASMGYITPFPRESTGTPAPRWVAEAKADARKHVQHGLDGEGRIVFERGPSGRIGVWLHQQDCRHYLTFHEGGHISDAWEFREQGGRLQALDLVDNGRGIDRTYHWQGDRLLREVMCNWSTTGRTWWCQDVYSYNDAGQLDRIVLEYLDKNGRATGQRRLQYQRPRPGETLATVTADVERLLIEAIAAQLPLIPRDEPLYCLLLCFTESDFTAAWPPFLVWGRQPYREAVLARGEDVAYYLWAPDEMRGVQGDAHECWFDDVALVEACKRHSQYMEMRGSDASAKRVLKNVAAWLDAPERRALLAATDDFVVAVADNTGSIDPLPGLRRAIGPERWGRLKERGYV
>NZ_CP018756.1|WP_079222556.1|2632452_2634780_-|TonB-dependent-receptor
MPSHTDSRRSSGMSSFVSFRRHPLALACAGLALVGSFGAAAQDSAPTPTGLDTITVTAEHREQNLQEVPVSVGVVQGERMRDFTAGGDDTLLALSGRVPSLYAETTTGRIFPRFYIRGLGNIDFYLGASQPVSIIQDDVVLEHVVLKSNPVYDVDQVEVLRGPQGSLFGRNTTAGIVKFDTIKPSEDYSGRVSASYASYNSVSIDGGFGGPINDVAAFRVSALYQHRDDYVDNTYTGPSADGTVSPKKNAMGGFDDRNVRAQLLLTPSDQFSILASAHARDYEGTSTLFLRNALTKGSNQTDVPRDKVAYDEADNNPQAYKTYGGSVKARYDFGAVDFTSITAYETTSGYSRGDTDGGAAVNFPVNGVPNGYGQSMGQIRDLDQWTQEFRLASHDDNALQWQAGAFYFNGSDTTDFYQRAWFLQGAARNPNNWVRLRNKNTSWAGFGQISYAFTDKFSITAGLRQTKDEKHTRLLKTADTAAGVVTYKGRTDVKMSDTTPSWDLSAMYQFNPNVSVYAKVARGFRGPTIQGRSAVFNADFTTADSETILSWEAGVKSSLWDNRLRLNATAFTYTVNDIQLNGNDSDGNGVLFNADKAKAYGFEADMELRPIPNLTLSAGVSLLHSEVQDKRVYAQVCALNGAVVCTVNDPTIKVGANTFVQIDGNPLPNAPKYNVNFAARYDFPVSDAGTMFVSTDWNKQGYTSFVLYDSKEFNSKGDFEGGLKLGYSGNYGAYEVALFARNITNEKNLKGVIENYMAAVYNEPRTVGVSLNMNW
>NZ_CP018756.1|WP_079222557.1|2634968_2637527_-|Cache-3/Cache-2-fusion-domain-containing-protein
MMTPAASRFSASPPRRSLTIASRLALLMAAITTVAFAALAVLIYRDTADSYQQRVSAGLDTATVLMRDSVQLYDRSLSESTERIAGTFRAMLPQGEAQADGTATIDVAGRSTPTLRLGSQAIGPASTEVDRFADATGGVATVFVRDGDDFVRVATSLRNAQGERVLGTVLDHANPAYARVLGGQGYTGPAHLFGTDYMTHYMPIRAADGSVAGIAFVGQDYSQGLAALKARLREATLGREGRFIVLDTRAGKERGRVVAATDGEGGLLQERVAAQDLPALQALLDGSSTQARLHLRPAAGGGEQAWFASAQRYGPWQWLVLGLEPQSVLDDVLNGLMLRIALISALALATVVTLIVLVVRRLLGRPLAAAAQVARDVASGRLDREIEVRRDDEVGRVLGSLQQMRSKLHEILQAQAAMGEQHAAGVVSHRIDEQAFEGEFRAMVAGTNALVAAHLQTQQRMVALVERYAEGDLQQTMDVLPGEQVAITQALNGVRSKLQGINGEIKRLVAAAAAGDFSVRGDAQAFANDFRQMVQGLNSVMGTADENLLALSGLLRNLAEGDLRHRIDGQSQGVFARMRGDANATVGALTGIVGRIQQAAGAVSLAAAEIAAGNDDLSRRTEQQAANLEESAASIEEMTSAVRQNADHARRADQLASEAAQVAGRGGVAMAEMQATMGLIDAASRRIAEIIAVIDGIAFQTNILALNAAVEAARAGEEGRGFAVVASEVRALAQRSTLAAAEIKGLIEDSVARVAEGNVLAGDAGRTIQDVVASVTELGGLVGEIAHACQEQAAGIELVNQSIVQMDGVTQQNAALVEEASASARAMSSQAHALQEAAGRFVLARSPLTAGV
>NZ_CP018756.1|WP_079222558.1|2637648_2637954_-|Rho-binding-antiterminator
MTDYQPLECDLHDVLEIACLHRALLQVELRDGSRFVARARTTESTADKEEFLLLDAPDGERRIRLDQLHAVATVGADGTAGARTVLGPGPADASGEAEQGF
>NZ_CP018756.1|WP_079222559.1|2638235_2639126_+|hypothetical-protein
MIGKNARTLIAAIVLLAIGAYAIWSGDGRDHSTAAGDPPAADHASLKAPAAPGLHAAGPATAAPPRPQPFAFGDLKARAQSGDAVSQRELAELYERCFAVNIAPENYLPAYEVMARHTPYPEETAEMMRTARSTAALCAKVDGGQIIPIEAIRAWLESAATRGDLAAQARLLLLNGEKPDAAAYTRLMDDVARSKDPAAVFRLGELVAHPTHSSATGRYADLSSDPISGHAWSIVGCRMGYDCSSGSPLMASVCLSGGGCAGENYEAYVRSSLITARDARLLDLRIREVSALLAQP
>NZ_CP018756.1|WP_174208691.1|2639153_2639330_-|hypothetical-protein
MNDKQNPNQQQAREGAQESRQDRRQDEVAKQRPGQDDQQVHDAHSRRPQRKDGSQDPA
>NZ_CP018756.1|WP_079222560.1|2639440_2640202_-|hypothetical-protein
MPKTADVHAIDWATLQGAYGDASEAGALLASMMDPQHQQDWNDIWSHLCHQGSVYSASHAALPVLLSIARQTGRSDGDDALLLAGAIVAGSDVGDPGLVPHGDVIQALRSKVHKRLQGTGKDAVPLSDDGHGERGWLRQAWLGLSGEKAWSQHLDRLAEGEIVGECVACSADLYCTLDAEAPYVCHEDPVFGAPSATTALLPGEPVGVAEQWLMHQVRDDGDQRAEQLLALAFGHSTCSACGHPFAVRECVQA

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Crispr_ID: NZ_CP018756_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_18

2756760-2756851

Orphan

Consensus_repeat	Method
ACGTGACGCATGCCTCCCGTGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_18

>merge|NZ_CP018756|18|2756760-2756851|CRISPRCasFinder
ACGTGACGCATGCCTCCCGTGCCCGTGCCACACCCCCCGGTAGCGCCGGGCCATGCCCGGCGGATGTGACGTGACGCATGCATCCCGTGCCC

>NZ_CP018756|18|17|2756760-2756851|CRISPRCasFinder
ACGTGACGCATGCCTCCCGTGCCC	GTGCCACACCCCCCGGTAGCGCCGGGCCATGCCCGGCGGATGTG
ACGTGACGCATGCATCCCGTGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079225312.1\|2767889_2768810_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP018756.1\|WP_079222649.1\|2745941_2747963_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP018756.1\|WP_079222650.1\|2748152_2751032_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP018756.1\|WP_079222659.1\|2768973_2770332_-\|glutathione-disulfide-reductase	unknown	unknown	gnl\|CDD\|235701
NZ_CP018756.1\|WP_079222660.1\|2770450_2771695_-\|DUF418-domain-containing-protein	unknown	unknown	gnl\|CDD\|225193
NZ_CP018756.1\|WP_079222653.1\|2756905_2758912_+\|M13-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341056
NZ_CP018756.1\|WP_079225314.1\|2767554_2767863_-\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NZ_CP018756.1\|WP_079222645.1\|2742905_2743577_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP018756.1\|WP_079222644.1\|2741338_2742700_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|237838
NZ_CP018756.1\|WP_079222658.1\|2766786_2767461_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP018756.1\|WP_079222656.1\|2764605_2765088_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|226383
NZ_CP018756.1\|WP_079222648.1\|2744900_2745755_-\|iron-sulfur-cluster-carrier-protein-ApbC	unknown	unknown	gnl\|CDD\|378455
NZ_CP018756.1\|WP_079222657.1\|2765084_2766671_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP018756.1\|WP_079222655.1\|2762815_2764471_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379359
NZ_CP018756.1\|WP_079222654.1\|2759039_2762078_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|224544
NZ_CP018756.1\|WP_174208692.1\|2744011_2744179_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222646.1\|2743573_2743996_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|334445
NZ_CP018756.1\|WP_079222647.1\|2744249_2744822_-\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|234753
NZ_CP018756.1\|WP_079222652.1\|2754570_2756676_+\|peptidase	unknown	unknown	gnl\|CDD\|226118
NZ_CP018756.1\|WP_079222651.1\|2751408_2754381_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079225312.1\|2767889_2768810_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.99866e-10
NZ_CP018756.1\|WP_079222649.1\|2745941_2747963_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	6.2253e-46
NZ_CP018756.1\|WP_079222650.1\|2748152_2751032_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	4.15233e-20
NZ_CP018756.1\|WP_079222659.1\|2768973_2770332_-\|glutathione-disulfide-reductase	gnl\|CDD\|235701	PRK06116, PRK06116, glutathione reductase; Validated.	0
NZ_CP018756.1\|WP_079222660.1\|2770450_2771695_-\|DUF418-domain-containing-protein	gnl\|CDD\|225193	COG2311, COG2311, Predicted membrane protein [Function unknown].	9.02217e-86
NZ_CP018756.1\|WP_079222653.1\|2756905_2758912_+\|M13-family-metallopeptidase	gnl\|CDD\|341056	cd08662, M13, Peptidase family M13 includes neprilysin and endothelin-converting enzyme I. The M13 family of metallopeptidases includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, EC 3.4.24.11), endothelin-converting enzyme I (ECE-1, EC 3.4.24.71), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the active site's S2' subsite allowing substrate specificity. NEP is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It degrades a wide array of substrates such as substance P, enkephalins, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyzes bradykinin, substance P, neurotensin, and Abeta. Endothelin-1 overproduction has been implicated in various diseases including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homolog of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease which plays a critical role in the nervous regulation of the respiratory system, while DINE is abundantly expressed in the hypothalamus and its expression responds to nerve injury. A majority of these M13 proteases are prime therapeutic targets for selective inhibition.	1.1163e-170
NZ_CP018756.1\|WP_079225314.1\|2767554_2767863_-\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.17741e-21
NZ_CP018756.1\|WP_079222654.1\|2759039_2762078_-\|TonB-dependent-receptor	gnl\|CDD\|224544	COG1629, CirA, Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism].	9.44177e-13
NZ_CP018756.1\|WP_079222644.1\|2741338_2742700_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|237838	PRK14862, rimO, 30S ribosomal protein S12 methylthiotransferase RimO.	0
NZ_CP018756.1\|WP_079222658.1\|2766786_2767461_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	4.15543e-38
NZ_CP018756.1\|WP_079222656.1\|2764605_2765088_+\|VOC-family-protein	gnl\|CDD\|226383	COG3865, COG3865, Uncharacterized protein conserved in bacteria [Function unknown].	1.0944e-70
NZ_CP018756.1\|WP_079222648.1\|2744900_2745755_-\|iron-sulfur-cluster-carrier-protein-ApbC	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	7.27709e-144
NZ_CP018756.1\|WP_079222655.1\|2762815_2764471_-\|SDR-family-oxidoreductase	gnl\|CDD\|379359	pfam13761, DUF4166, Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.	2.00954e-32
NZ_CP018756.1\|WP_079222657.1\|2765084_2766671_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	6.91199e-104
NZ_CP018756.1\|WP_079222646.1\|2743573_2743996_+\|HIT-domain-containing-protein	gnl\|CDD\|334445	pfam01230, HIT, HIT domain.	1.07958e-14
NZ_CP018756.1\|WP_079222647.1\|2744249_2744822_-\|dCTP-deaminase	gnl\|CDD\|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	7.73475e-110
NZ_CP018756.1\|WP_079222645.1\|2742905_2743577_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	1.5715e-38
NZ_CP018756.1\|WP_079222652.1\|2754570_2756676_+\|peptidase	gnl\|CDD\|226118	COG3590, PepO, Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP018756.1\|WP_079222651.1\|2751408_2754381_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.13942e-25

>NZ_CP018756.1|WP_079222652.1|2754570_2756676_+|peptidase
MTRTPKIVLLTLAVSAALVGCGKTDTPAKDATASTPAATDQATTYKLDEAKLPAYNAFQASDLDSAMDACGAFGDYVNSKWLAANEIPGDRTSWGAFTILDERSVAVQHQLAEQLAQVKNPNHIEKIVGDLWATGMDEAKINAQGIEPLKGDLAAIDGLQDKAAIADYLRTSAAKGDNVLFGFGAEADFKNSAMNMAYASQGGLGLPDTTYYTDTKNADKLKAYQAHVAKVLELSGVAAADAAKQAEDVVKFETRLAKASKSRVDLSRNVELFYNPVTLADADKLTPNFSWTEFFKSQGVAAPEKFSLAMPAFHEEVSKALGDTDPSVWRAYLRFHTVDGASPYLADAFVQENYEFYGKTLNGQKEQKPRWKRVLGTIENDAGEAFGQLYVKVAFSPEAKAKMEELVKNLAASLKERIQGLSWMSDETKAKAIAKWETFTPKIGYPDKWRDWAGLQTQRDSYLGNVRAANEFNYKFNLSKVGKPVDKTEWGMTPQTVNAYYNPLQNEIVFPAAILQPPFFDPKADDALNYGGIGAVIGHEMTHGYDDQGARFGPTGNLEDWWTPADKKNFEGLTGKLVKQFDQYKVDGQAVNGHLTLGENIADLGGLATAYDALQKATAGKEDPKVDGFTRDQRFFFNWATVWRTKYTAENAKVRLATDPHAPAQFRAMGAPSNLPTFAAAFQCKAGSPMARTGDQQVVIW
>NZ_CP018756.1|WP_079222651.1|2751408_2754381_+|TonB-dependent-receptor
MTIHRTPGRHPLTCALLAGLMAAAAAPAFAQDAESTGNRAVDLDKVTVTGSRIARTGFVTPSPVTAISAEEIRGTGAVNIGDLMAKMPQLTPTYTMGNSTRFIGTAGLGLMDLRGMGTARTLVLVNGRRHVGASPGSTAVDVNTIPVEWIERVEVITGGASAVYGADAVAGVVNFIMKKKFDGFELRAQRGAASEGSFDRSFISFSGGKDFADGRGSAAIAMEYSTQGRYGRGDRAIGREFLTTVNNPDYDRTKPPSESNPQTILQGPGGNHALSYGGTFTLGAFRADGSNRYVFNPDGTFRKNRYDGTIVSANTCTNCDFADLNAVADLEPAFNRFSFNTAVNFDLNDDHRLFFEGKYTKTESEFFGQPTFDQVGTARALRIQRDNAYVTPELGALMDANGLSTLLVSRFNVDSGRRGENVERSTARAVLGLEGNLGADWTYEASANFGQTTIDRINFNNRIEERWQAGLDAVINPANGQIVCRSTLNPNAVNPYTGRAYSAALVAGCVPFNVMGNGKVSPEAAAWFNTNSLNQSKLKQQVFSASVANGSLFSLPAGDMGIAAGVEYRKEQSQENTDPLSAMGLTFLNAIPSRGGEYDTKEAFVETSVPLLADIPGIRRLNLDLAGRYSDYSTIGETKTWNVGLDWEVLSSLRFRASLAKAVRAPSIGELFNPQSQNFATINDPCNTLSTNSNRPSTAKDPALRAANCAALGIPSNWVDTYTATRPGVSGGNPDLKPERSKSVTMGFVWQPEFLDGFGMSMDYWRITLEDAIGSVTAQTNATRCVDSPGGVQNNSFCDMVVRASGTAGTPYSIIGWTALAENLAKSRRVGVDVEMDYRFQLAGGNTTLRLVGTRLIQSREWAFQAFPDEFTEYVTYYSDPRWRGQFNVNYDLGNFRAKWDMIYVDGNLRVTPDSYKSNPGSQSPIRNPSYLYHNMQVGYKIADSGVEVYLGVDNVFDKDPPVNYFGTDLGSSYYDMVGRYAYVGVTYKF
>NZ_CP018756.1|WP_079222650.1|2748152_2751032_+|TonB-dependent-receptor
MRTANRQIKPSRVPLTLAVLACLQAAPVFAQEAEPQQPTTTSSSASKNATNLDAISVTGSLIKRPEYETTSPVQVISIEKGIASGQFDTADFLQTSAIAAGSTQMNNQFGGFVVEGGTGVQTVSLRGLGANRTLVLLDGQRPGPAGTRGQVGSFDLNVIPQAILQRIEIVKDGSSSIYGSDALAGVVNLITKKSIDRPEMTYSMSVPQHGGGEQFSASIANGWNFEKGSIVAAAQWDRLNALTVGDRDFFSCAQDMVWGTDGKRIDREDRSILAGTDLAGCSTGNLYANTIINYNNSAIRYVPSPDGSTVGPFPGYRPRPRPTPTYANGGTAYYEDVLNYPFYHDQEVINQRERATLYAATDFSFDSFNWKTQFLYNRRETKAHSWRQFFPIVYSEAADDLFQVIMPFPSDQKITVDYFYGTTKFDGQFKSTESWAWEINAGYSRSSGDYGALAIDATRTGDLSYDNSGDMPVDYFNAGFLSGQRMDELVNAIGQYHTGNTVYEQTSANAILSGNLFTLPAGDVASAFGVEFRKYKINDTPSEFSRSGNIWGSSTADITKGTDKVKEAFAEVDVPLLKGIPGIESLSVNLSGRVFEYDSVSGSDKVWKTGVNWQIVPSLRVRGTMGTSYRAPGLYELYLGNQTGFLAQNQIDPCILWGDSNNDFLRANCGAAGIPETYAGGGGSATIYSGGGAGQLKPETSKAKTLGLVWTPTFANLNIALDYFDYDVRGEITQLDEYDIVFGCYGSAVYPNSFCNNLVRNSPTDPANPNQITTIYNQYVNINRERTRGYDLQINYDNDFAFGKLSAEAQVTYTLEDTYQLFDSAADSGFTTSDQVGYIGRPKTVGLASVSLERGDWAFNWQGVYNSSTQNKDLDRTFTYSGYQNATRDIKAGWQFRHNVSVAYNMDDWSLMVGVRNLFDKAPDLISNTAGTRYGNTPLYASQYDWYGRTFFARVSYKF
>NZ_CP018756.1|WP_079222649.1|2745941_2747963_+|S9-family-peptidase
MHVIPRFRLGTALALALAGTSAHAAPVPIEDLARLPALQSVSMSPDGKHLVALIPSPANPEETALASWDTDSLSGGPKVVTPSGDRMKFIAAAALKSDRILAVGRQEWTGQLGGCGEGSVSGATKTFVVKTYLTDTTQKDFGEAFADNTRKLGVSEQTQRCLELGGTASLVNMLPLDPDRVIIRQLSEISLTANYYLYNLKTKETELLFRGGTRAQPALFDARTGKVLAKAQIEPVSGDYEQQVLILDPSSGQFVLQKPLLSKLSNRHSVELAGVDDATGKYYILTDLFSDKVQAHLYDAKLQKFDPEPVLANPNFSIASLVFSTQPKTFNQVVGFTIDGPSAQTVYVDPTLKSIQDTLKQAAGGRQVEIARYNDDFSRILFRAVGPDAPTSYFLLLDRKNVVSLGSERPWIAKGATGEERWVTYKARDGREIPAILDLPQGWKDGDPAPPAIVNPHGGPWARDYVQWDASGWIALLTSRGYAVLRPQYRGSSGLGRELWIAGDREWGQKMSDDNDDGAAWLVSQGFAAKDRIAIFGYSYGGFAAAAATVRPNSPYQCAIAGAPVTDLARLGTSWSDNRLQRILQGQTVKGMDPMRNTASANIPVMLFVGDRDVRTPSFHAQGFYDAVKGKVPAKFHLIADQQHSMPWYPRQQRETLGLIESFLKNDCGPGGL
>NZ_CP018756.1|WP_079222648.1|2744900_2745755_-|iron-sulfur-cluster-carrier-protein-ApbC
MNSPARRPHASQVQKGLSPHARIRNVIAVGSGKGGVGKSTTSVNLAVALQQLGARVGVLDADIYGPSVPAMLGLSGRPESPDNKSIEPMRAFGVDTMSIGYLVEDETPLIMRAPRATAALTQLFEDTLWDDLDYLLIDLPPGTGDIQLTLVQKIPLAGAVIVTTPQDIATLDAKKALKMFEKVEVPVLGIVENMAVHTCSNCGHVEHLFGEGGGERMAAQYGVPLLGSLPLQIDIREQGDAGSPITVAQPESTAAQAYRRAAERLVDEVGKRPRASIQILSSLL
>NZ_CP018756.1|WP_079222647.1|2744249_2744822_-|dCTP-deaminase
MSIKSDRWIRRMSEQHGMIEPFEAGQVKHANGERIVSYGTSSYGYDVRCSREFKVFTNINSTIVDPKHFDPGSFVDIVGDECIIPPNSFALARTVEYFRIPRDTLVVCLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTPLPARIYANEGVAQMLFFQAAADDVCETSYKDRGGKYQGQTGVTLPRT
>NZ_CP018756.1|WP_174208692.1|2744011_2744179_+|hypothetical-protein
MRFNLVAAILLILIGLFMLASNLGWTHLNVSKLFLTWWPVGLVGVGIAMLFGRGK
>NZ_CP018756.1|WP_079222646.1|2743573_2743996_+|HIT-domain-containing-protein
MSDFELDSRLATDSVLVAEGPLSQVRLMNDERFPWLVLVPRLAGITEWIELDGEQQDKLRTELNRACKALHGSDGVEKINIGALGNIVRQLHFHVIGRHDGDPAWPGPVWGSGPAHRYEPAALDQHVAYWKERLGYPAHP
>NZ_CP018756.1|WP_079222645.1|2742905_2743577_+|dienelactone-hydrolase-family-protein
MSEWITLDTHHGPVRAWQVLPEGKPRAALVVIQEIFGVNAHMRGVAERFAAEGYAVLAPSFFDLVDGPESDPDALPYSPEGVKDGLERVNTLGMEKALEVVRAAATRLAPYGKVGTVGYCWGGSVALLAAMRLGLPSASYYGGRNVNFLDETPKAPVIFHFGAQDKSIPPEAVQAHREKLPQMATYVYPADHAFNREVGHAYDPDSAALALQRTLDFFTEHLG
>NZ_CP018756.1|WP_079222644.1|2741338_2742700_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MSQLNPKVGFVSLGCPKALVDSERILTQLRSEGYDIVPSYDSADVVVVNTCGFIDSAVTESLDAIGEAMNQNGKVIVTGCLGKRPEQIREAYPNVLAVSGPQDYQSVMEAVHEALPPKHDPFVDLVPDYGIKLTPRHYAYLKISEGCNHKCSFCIIPSMRGKLVSRPVDEVLREAERLVRGGVRELLVVSQDTSAYGVDVKYAEKMWRDKAYQTRLKALCEGLSELDAWVRMHYVYPYPHVDEVVPLMAENRILPYLDIPFQHASPRILRLMKRPGAVEKTLERVQNWRRIAPDITVRSTFIVGFPGETEAEFEELLSFLDEAQLDRVGAFAYSPVEGATANDLPDAVPEEVKQERLARFMEKQAQISAARLEAKIGTVQQCLVDAIEGDIAVARSKADAPEIDGLVHIQNADQVPLRVGEFVNVEITESDEHDLYGDALPSAARPAFDLKVL
>NZ_CP018756.1|WP_079222653.1|2756905_2758912_+|M13-family-metallopeptidase
MPNFRPLAVALGISLATLVPTHDAFAAKKKAVRAPAVSAQCSDFYDATNADWLKANPVPQSGSATALGQLVDRSRQQQRELLDASMKAPQGNVQKLLGDFWASGLDEAAVEADGSNPIAPLLTRINAIKKAKDVPASIAALHQVGIPVAFNFGPDVDLKALDRHIGYFMQGGMGLPDPAFYTRTDADTVALMGRYRNYVKQILALTGTPAAKLDAESQSVIELETELARNAQSLAGINNPFNNYAPISTKDLNSRYRNLQLDAFLKAQGVNDDLVSLADPGLFKQLDTMVTKLKPEQWKAYLRWRVGDSMAPYLSKAYRDAEFEFRGRVLRGQTLPAQRWESVLDAINVAAGPMVGREYAARYLSAEDRRQAAWIVDKVREVQIEAVKNSTWMSAEAKAEAQAKLGALKIEIGTPLRDLDYTVQPMGRGSFGGNMLIASTWRHREEMKRIGKGNADRRWDVLPQQPSLAYDLAQNRLIVTAAILQGPVFNAKADAADKFGSFGGLVGHELNRAIDAKGALVDAKGELRSWWTPADKTAWTLLGSRVAAQYGAYEFPGVKGAKVNGTLTQEENLADIAGLELAWAAYTAQEPKAKPAQQQGFFRAWAALWPQQLSPNEAARRLTADIRAPGRWRTNGPLSNLPAFGATFSCKAGQPMQRTDAEQIKVWR
>NZ_CP018756.1|WP_079222654.1|2759039_2762078_-|TonB-dependent-receptor
MTYSKTAIRLKRTALAAVLTSFIGAAAAQSTTGSLYGNAPAAAGATVVVQSDSGLKRSANVDANGRYNLGSLPVGRYSITLERDGQVVEQRDNVLLKVGVGTEVSFGQSASGGATNLDAVNVTAANIPKIDVTNTVSKSVITSEQLDVLPLGRSAEAIALLAPGVVAGSGEFSNGSRSVLSFGGSSVTENAYYLNGFNATNPLNAMGGVSLPYGSIDQQETFMGGYGAGYGRSTGGVINQLGKRGTNEWKFGFQTTWSPDSLAESPRDIYYPNHTAPPGLELEDPTGTVAGSLYRSRKGDKATRTTYSGYVSGPLIEDRLFIHLAAEKDRNEGVSTSAAEAAQQIRSHYTTDTPKFYGKIDWNINDSNTLEYTRLQNTDRYGSYYRDFDYDTMSEGERTGTFANTTKLKDEFDVFKYTGYLTDDLTLSAVWGRSKETNLESNPKDSANPYISGPTSQDPSITGGTPIRNDQTALYTKSLDAGSKTRGLRVDLQYRIGSHELTAGIDNMTYQAHNEGQAMTGPGYAWIYSRIAPGSSPAPAFDVAAPGGDGYYVYKYIFSTTTSMSVEQKAYYLEDRWQVSPNWLLTLGLRNDKFTNYNSSAIAYVESGDQWAPRLGASWDVFGDSSLKVFANLGRYYLALPNSVAIRGASASTYTSEYFTYGGIDANGNPTDLTALGPGPVSTNNEYGVAPDPLSVAPTDLKSQYQDEFIMGFEKTLGSSWNTGAKFTYRRLQTAIDDTCDSDQIYAKLDAMGVDTDGLEVPGCVIFNPGKTNTFMVKHSDGSGYTPVQMSSSDWGYNGNKAKRSYVAVDLFIEHPLSDKWYGRLDYTWSRSYGNTEGQVKSDIGQDEAAKTQDWDSYYLMEYAGGYLANDRRHQLKGYGAYQFNDEWTASATLRVTSGMPKSCLGYYGADGSDPIGYRSSYHYCNGEPSRPGDAGRQPWTYRLDLGVMYRPAFADHKLAFGLDVFNVLNQRRAVQSDPTYESGQHTVSNTYGIGTFYTAPRSVRLSASYDF
>NZ_CP018756.1|WP_079222655.1|2762815_2764471_-|SDR-family-oxidoreductase
MKILILGGYGVFGGRLVQLLADLPQLELLVAGRTLAAAEAFCLAYRGQSTLRPLRVDRQQLVPTLQAERPDLVVDASGPFQDYGRQRYAAIEACIAAGIDYLDFADAADFVSGVPQFDAQARAAGVYVLSGVSSFPVLTAAVLRVMAMRMDILSVEGGIAPSPYAGIGLNVMRAVVGYAGAPVKLRRGGRDSHGVGLAESRRFTVAVPGRIPLRNLHFSLVDVPDLQVLPPEHPTLTDIWIGAGPVPEVLHRILNVLAKARQHLRLPSLEPCSQLFYTVLNLMKFGEHRGGMIVRAVGVRDGAPVRQSWHLLAEADDGPYIPSMVIEALIRKQLLGERPAPGARPATHALELADYDRLFAGRTIHTGFRHDMPGASLYQRVLGDAYARLPAAVQALHAPGAARRWQGRAQVQRGRGLLSRLLGTLFGFPAAGEQVPVSVEFTPEAGGERWTRTFAGRRFSSLQTEGRGRNDALLVERFGAVSVALAVVVEGGQLQLVPRRWSLLGIPLPRALLPGENSFESEVDGRFVFDVEIGAPLVGRIVHYRGTLEPG
>NZ_CP018756.1|WP_079222656.1|2764605_2765088_+|VOC-family-protein
MAIRNIICVWYDKDALEAATFYANTFPDSAVTAVHHAPGDYPAGQEGAVLTVEFTVCGVACVGLNGGPTFKHNEAFSFQIQTTDQAETDRLWNAIVGNGGQESDCGWCKDRWGVSWQISPRMLIEAVTSTDKALAKRAFNAMMPMKKIDIATIEAAIAQA
>NZ_CP018756.1|WP_079222657.1|2765084_2766671_+|NAD(P)/FAD-dependent-oxidoreductase
MSQWDAIIVGGGHNGLVCAAYLARAGKKVLVLERRNVLGGAAVTEEFHPGFRNSVASYTVSLLQPKVIDDLQLHAHGLRIINRPANNFLPLDDGRYLLSAPGRTQAEVAKFSARDAQRLPEYEARLEIFADVLRAWALRAPPDLGVAGGWRALPALWQMGRLGRELATLDASLRQELLDLFTLSAAEYLDRWFESEPIKALFGFDGIVGNFASPYTPGSAYVLLHHVFGQCNGVKGAWGHAIGGMGAISQAIAASARDAGAELRVDAGVRRVLVEQGRAAGVELDNGESLRARTVIANVNPKLLYERLLEPAEVPQATRERMAQWRCGSGTFRMNVALSRLPDFRALPGHGDHLSAGIIMAPSLEYMDRAWLDARREGWSREPIVEMLIPSTLDDSLAPPGQHVASLFCQHVAPVLPGGRHWDDHRDEVADLMIATVEQHAPGFAASVLGRQVLSPLDLERTFGLIGGDIFHGALSANQLFSARPMVGQAGYRGALPGLYLCGSGTHPGGGVTGAPGHNAAQVVLQDS
>NZ_CP018756.1|WP_079222658.1|2766786_2767461_-|rhomboid-family-intramembrane-serine-protease
MFPRLPTVTKALLIANAILFLLQQPFLLGMQTFEPFMLQPWQQGFDAFSPGGNFQPWQLLTYGFLHGSFGHLFFNMLAVFMFGAPLEQTWGEKRFLLYYLVCVAGAGVCQLLVGTLLENPATVLGASGGVFGLLLAYGMLFPNQRVMLLFPPIPMKARTFVILFGVGELVLGMTGWQPGVAHFAHLGGMLFGWLLIRYWRGQPPFNKRRPPGPPKRPNHLRSVK
>NZ_CP018756.1|WP_079225314.1|2767554_2767863_-|MGMT-family-protein
MAVIRAIPPGQVLGYGQVAMRAGLPGRARLTARILGQNEDPGLPWHRVLRSDGRIAMAEGSAGWREQSQRLRAEGVVVENGRVRMPAIDPAAALDAAIWGPG
>NZ_CP018756.1|WP_079225312.1|2767889_2768810_-|DMT-family-transporter
MSSPSPRIATASPRIALGGIGLAAVGAIAASGKAIIVKLGLRHGVDATTLLALRMLMALPLFVLMALWSARRTEPLSWADRARVLWLGLTGYYLSSLLDFQGLQYISVTLERLILYLNPTLVLLINVLLARQRPGRWQVAALALSYLGVLLAFGHDLQREGGQIIVGSLLVLGSALSYALYLFGSGQVVARIGAVRLTAYASCVASALVLLHFAITHPLPLLWQAPAAVQWLSLVNATVCTVLPVLAIMLAVQRVGSSLAAQVGMLGPVSTIVMSLWLLDEPMGPAQIAGTVLVLIGVLLVTRLRR
>NZ_CP018756.1|WP_079222659.1|2768973_2770332_-|glutathione-disulfide-reductase
MSTASFDYDLIVLGGGSAGLAGAIRAAQHGKRVALLEPGALGGTCVNVGCVPKKAMWLAADLHERIGLASAMGFDVPARPALSWKELVIHRQAYISNIHTSYNKRLDETGVVRIPARGHLVDAHTVACSDGVRYSAEHILIATGAHPQRPDIPGAALGLVSDDFFDLRSAPAEVAIIGGGYIAVELAGLLQALGSRVSLLVRGARLLERFDYELTDQLAENLKQQGVRIHFDYRLRELQREGERVRAFGHDGPLDSVFDAVFFATGRRGNSRDLGLEALGIGIGEHQQVEVDEWQTTAVPSVHAVGDIAGKVGLTPVAVAAARRLMDRLFGGRPSAKMDYSNVASVVFSHPPLGAVGMSEEQARACFDQVTVYHSRFRPMLQALANGTQRSLFKMVCAGADERVVGIHLLGEAADEILQGFAVAVKMGATKAQFDDTVAIHPTSAEEVVLMR
>NZ_CP018756.1|WP_079222660.1|2770450_2771695_-|DUF418-domain-containing-protein
MADLPAGCPVNAASLSLQPVASGERIAVLDVLRGVALLGILLMNIEAFSGPLDLAFTGIDARWHGLDYVADAFVYIFVQGKFFTLFSLLFGAGFAVMAQRAQAAGREFTPFYLRRSLGLALIGLCHALLVWSGDILVLYALVSLPLLACREAPRSWLPWMGIVVYLAGVSMMLLIGAMVTLSPAQDLQKMVVDAQQAIDQQRLVYGQGSWLQGNVQRLHEFGSSLGALVITGPEVLGMFLIGSWFAGSGALAEPDRFPRLYAGLRWVALPLGLLVTLAGVLWKPYLAPGQYTLETTAVMSLVSVGAVPMCLGYLAWIVHWRARLGWLAPAGRMALTHYLAQSLACTWLFNHYGLGGFDLMPRAWQVVFALLLFALQVGISHWWLRRFRFGPMEWLWRAMTYRQWPPMRREVAQG

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Crispr_ID: NZ_CP018756_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_19

2766674-2766757

Orphan

Consensus_repeat	Method
GCGTGCCGACCAACGGTCGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_19

>merge|NZ_CP018756|19|2766674-2766757|CRISPRCasFinder
GCGTGCCGACCAACGGTCGGCACCCACAAACACCTACAGCGTCAAATGATCCGATCCAGAGCGTGCCGACCAACGGTCGGCACC

>NZ_CP018756|19|18|2766674-2766757|CRISPRCasFinder
GCGTGCCGACCAACGGTCGGCACC	CACAAACACCTACAGCGTCAAATGATCCGATCCAGA
GCGTGCCGACCAACGGTCGGCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079225312.1\|2767889_2768810_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP018756.1\|WP_079222658.1\|2766786_2767461_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP018756.1\|WP_079222654.1\|2759039_2762078_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|224544
NZ_CP018756.1\|WP_079222659.1\|2768973_2770332_-\|glutathione-disulfide-reductase	unknown	unknown	gnl\|CDD\|235701
NZ_CP018756.1\|WP_079222665.1\|2775543_2776839_-\|transporter	unknown	unknown	gnl\|CDD\|379259
NZ_CP018756.1\|WP_079222660.1\|2770450_2771695_-\|DUF418-domain-containing-protein	unknown	unknown	gnl\|CDD\|225193
NZ_CP018756.1\|WP_079222653.1\|2756905_2758912_+\|M13-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341056
NZ_CP018756.1\|WP_079222649.1\|2745941_2747963_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP018756.1\|WP_079222650.1\|2748152_2751032_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP018756.1\|WP_079222663.1\|2773059_2773830_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|223862
NZ_CP018756.1\|WP_079222656.1\|2764605_2765088_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|226383
NZ_CP018756.1\|WP_079222648.1\|2744900_2745755_-\|iron-sulfur-cluster-carrier-protein-ApbC	unknown	unknown	gnl\|CDD\|378455
NZ_CP018756.1\|WP_079222664.1\|2774072_2775425_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NZ_CP018756.1\|WP_079222655.1\|2762815_2764471_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379359
NZ_CP018756.1\|WP_079222662.1\|2772388_2772928_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|223862
NZ_CP018756.1\|WP_079222657.1\|2765084_2766671_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP018756.1\|WP_079225314.1\|2767554_2767863_-\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NZ_CP018756.1\|WP_079222661.1\|2771794_2772277_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223976
NZ_CP018756.1\|WP_079222652.1\|2754570_2756676_+\|peptidase	unknown	unknown	gnl\|CDD\|226118
NZ_CP018756.1\|WP_079222651.1\|2751408_2754381_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079225312.1\|2767889_2768810_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.99866e-10
NZ_CP018756.1\|WP_079222658.1\|2766786_2767461_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	4.15543e-38
NZ_CP018756.1\|WP_079222654.1\|2759039_2762078_-\|TonB-dependent-receptor	gnl\|CDD\|224544	COG1629, CirA, Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism].	9.44177e-13
NZ_CP018756.1\|WP_079222659.1\|2768973_2770332_-\|glutathione-disulfide-reductase	gnl\|CDD\|235701	PRK06116, PRK06116, glutathione reductase; Validated.	0
NZ_CP018756.1\|WP_079222665.1\|2775543_2776839_-\|transporter	gnl\|CDD\|379259	pfam13557, Phenol_MetA_deg, Putative MetA-pathway of phenol degradation.	0.000635096
NZ_CP018756.1\|WP_079222660.1\|2770450_2771695_-\|DUF418-domain-containing-protein	gnl\|CDD\|225193	COG2311, COG2311, Predicted membrane protein [Function unknown].	9.02217e-86
NZ_CP018756.1\|WP_079222653.1\|2756905_2758912_+\|M13-family-metallopeptidase	gnl\|CDD\|341056	cd08662, M13, Peptidase family M13 includes neprilysin and endothelin-converting enzyme I. The M13 family of metallopeptidases includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, EC 3.4.24.11), endothelin-converting enzyme I (ECE-1, EC 3.4.24.71), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the active site's S2' subsite allowing substrate specificity. NEP is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It degrades a wide array of substrates such as substance P, enkephalins, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyzes bradykinin, substance P, neurotensin, and Abeta. Endothelin-1 overproduction has been implicated in various diseases including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homolog of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease which plays a critical role in the nervous regulation of the respiratory system, while DINE is abundantly expressed in the hypothalamus and its expression responds to nerve injury. A majority of these M13 proteases are prime therapeutic targets for selective inhibition.	1.1163e-170
NZ_CP018756.1\|WP_079222649.1\|2745941_2747963_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	6.2253e-46
NZ_CP018756.1\|WP_079222650.1\|2748152_2751032_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	4.15233e-20
NZ_CP018756.1\|WP_079222663.1\|2773059_2773830_+\|C40-family-peptidase	gnl\|CDD\|223862	COG0791, Spr, Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane].	4.83284e-38
NZ_CP018756.1\|WP_079222656.1\|2764605_2765088_+\|VOC-family-protein	gnl\|CDD\|226383	COG3865, COG3865, Uncharacterized protein conserved in bacteria [Function unknown].	1.0944e-70
NZ_CP018756.1\|WP_079222648.1\|2744900_2745755_-\|iron-sulfur-cluster-carrier-protein-ApbC	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	7.27709e-144
NZ_CP018756.1\|WP_079222664.1\|2774072_2775425_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	1.97586e-126
NZ_CP018756.1\|WP_079222655.1\|2762815_2764471_-\|SDR-family-oxidoreductase	gnl\|CDD\|379359	pfam13761, DUF4166, Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.	2.00954e-32
NZ_CP018756.1\|WP_079222662.1\|2772388_2772928_+\|C40-family-peptidase	gnl\|CDD\|223862	COG0791, Spr, Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane].	1.92845e-40
NZ_CP018756.1\|WP_079222657.1\|2765084_2766671_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	6.91199e-104
NZ_CP018756.1\|WP_079225314.1\|2767554_2767863_-\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.17741e-21
NZ_CP018756.1\|WP_079222661.1\|2771794_2772277_-\|peptidylprolyl-isomerase	gnl\|CDD\|223976	COG1047, SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones].	1.95517e-54
NZ_CP018756.1\|WP_079222652.1\|2754570_2756676_+\|peptidase	gnl\|CDD\|226118	COG3590, PepO, Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP018756.1\|WP_079222651.1\|2751408_2754381_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.13942e-25

>NZ_CP018756.1|WP_079222657.1|2765084_2766671_+|NAD(P)/FAD-dependent-oxidoreductase
MSQWDAIIVGGGHNGLVCAAYLARAGKKVLVLERRNVLGGAAVTEEFHPGFRNSVASYTVSLLQPKVIDDLQLHAHGLRIINRPANNFLPLDDGRYLLSAPGRTQAEVAKFSARDAQRLPEYEARLEIFADVLRAWALRAPPDLGVAGGWRALPALWQMGRLGRELATLDASLRQELLDLFTLSAAEYLDRWFESEPIKALFGFDGIVGNFASPYTPGSAYVLLHHVFGQCNGVKGAWGHAIGGMGAISQAIAASARDAGAELRVDAGVRRVLVEQGRAAGVELDNGESLRARTVIANVNPKLLYERLLEPAEVPQATRERMAQWRCGSGTFRMNVALSRLPDFRALPGHGDHLSAGIIMAPSLEYMDRAWLDARREGWSREPIVEMLIPSTLDDSLAPPGQHVASLFCQHVAPVLPGGRHWDDHRDEVADLMIATVEQHAPGFAASVLGRQVLSPLDLERTFGLIGGDIFHGALSANQLFSARPMVGQAGYRGALPGLYLCGSGTHPGGGVTGAPGHNAAQVVLQDS
>NZ_CP018756.1|WP_079222656.1|2764605_2765088_+|VOC-family-protein
MAIRNIICVWYDKDALEAATFYANTFPDSAVTAVHHAPGDYPAGQEGAVLTVEFTVCGVACVGLNGGPTFKHNEAFSFQIQTTDQAETDRLWNAIVGNGGQESDCGWCKDRWGVSWQISPRMLIEAVTSTDKALAKRAFNAMMPMKKIDIATIEAAIAQA
>NZ_CP018756.1|WP_079222655.1|2762815_2764471_-|SDR-family-oxidoreductase
MKILILGGYGVFGGRLVQLLADLPQLELLVAGRTLAAAEAFCLAYRGQSTLRPLRVDRQQLVPTLQAERPDLVVDASGPFQDYGRQRYAAIEACIAAGIDYLDFADAADFVSGVPQFDAQARAAGVYVLSGVSSFPVLTAAVLRVMAMRMDILSVEGGIAPSPYAGIGLNVMRAVVGYAGAPVKLRRGGRDSHGVGLAESRRFTVAVPGRIPLRNLHFSLVDVPDLQVLPPEHPTLTDIWIGAGPVPEVLHRILNVLAKARQHLRLPSLEPCSQLFYTVLNLMKFGEHRGGMIVRAVGVRDGAPVRQSWHLLAEADDGPYIPSMVIEALIRKQLLGERPAPGARPATHALELADYDRLFAGRTIHTGFRHDMPGASLYQRVLGDAYARLPAAVQALHAPGAARRWQGRAQVQRGRGLLSRLLGTLFGFPAAGEQVPVSVEFTPEAGGERWTRTFAGRRFSSLQTEGRGRNDALLVERFGAVSVALAVVVEGGQLQLVPRRWSLLGIPLPRALLPGENSFESEVDGRFVFDVEIGAPLVGRIVHYRGTLEPG
>NZ_CP018756.1|WP_079222654.1|2759039_2762078_-|TonB-dependent-receptor
MTYSKTAIRLKRTALAAVLTSFIGAAAAQSTTGSLYGNAPAAAGATVVVQSDSGLKRSANVDANGRYNLGSLPVGRYSITLERDGQVVEQRDNVLLKVGVGTEVSFGQSASGGATNLDAVNVTAANIPKIDVTNTVSKSVITSEQLDVLPLGRSAEAIALLAPGVVAGSGEFSNGSRSVLSFGGSSVTENAYYLNGFNATNPLNAMGGVSLPYGSIDQQETFMGGYGAGYGRSTGGVINQLGKRGTNEWKFGFQTTWSPDSLAESPRDIYYPNHTAPPGLELEDPTGTVAGSLYRSRKGDKATRTTYSGYVSGPLIEDRLFIHLAAEKDRNEGVSTSAAEAAQQIRSHYTTDTPKFYGKIDWNINDSNTLEYTRLQNTDRYGSYYRDFDYDTMSEGERTGTFANTTKLKDEFDVFKYTGYLTDDLTLSAVWGRSKETNLESNPKDSANPYISGPTSQDPSITGGTPIRNDQTALYTKSLDAGSKTRGLRVDLQYRIGSHELTAGIDNMTYQAHNEGQAMTGPGYAWIYSRIAPGSSPAPAFDVAAPGGDGYYVYKYIFSTTTSMSVEQKAYYLEDRWQVSPNWLLTLGLRNDKFTNYNSSAIAYVESGDQWAPRLGASWDVFGDSSLKVFANLGRYYLALPNSVAIRGASASTYTSEYFTYGGIDANGNPTDLTALGPGPVSTNNEYGVAPDPLSVAPTDLKSQYQDEFIMGFEKTLGSSWNTGAKFTYRRLQTAIDDTCDSDQIYAKLDAMGVDTDGLEVPGCVIFNPGKTNTFMVKHSDGSGYTPVQMSSSDWGYNGNKAKRSYVAVDLFIEHPLSDKWYGRLDYTWSRSYGNTEGQVKSDIGQDEAAKTQDWDSYYLMEYAGGYLANDRRHQLKGYGAYQFNDEWTASATLRVTSGMPKSCLGYYGADGSDPIGYRSSYHYCNGEPSRPGDAGRQPWTYRLDLGVMYRPAFADHKLAFGLDVFNVLNQRRAVQSDPTYESGQHTVSNTYGIGTFYTAPRSVRLSASYDF
>NZ_CP018756.1|WP_079222653.1|2756905_2758912_+|M13-family-metallopeptidase
MPNFRPLAVALGISLATLVPTHDAFAAKKKAVRAPAVSAQCSDFYDATNADWLKANPVPQSGSATALGQLVDRSRQQQRELLDASMKAPQGNVQKLLGDFWASGLDEAAVEADGSNPIAPLLTRINAIKKAKDVPASIAALHQVGIPVAFNFGPDVDLKALDRHIGYFMQGGMGLPDPAFYTRTDADTVALMGRYRNYVKQILALTGTPAAKLDAESQSVIELETELARNAQSLAGINNPFNNYAPISTKDLNSRYRNLQLDAFLKAQGVNDDLVSLADPGLFKQLDTMVTKLKPEQWKAYLRWRVGDSMAPYLSKAYRDAEFEFRGRVLRGQTLPAQRWESVLDAINVAAGPMVGREYAARYLSAEDRRQAAWIVDKVREVQIEAVKNSTWMSAEAKAEAQAKLGALKIEIGTPLRDLDYTVQPMGRGSFGGNMLIASTWRHREEMKRIGKGNADRRWDVLPQQPSLAYDLAQNRLIVTAAILQGPVFNAKADAADKFGSFGGLVGHELNRAIDAKGALVDAKGELRSWWTPADKTAWTLLGSRVAAQYGAYEFPGVKGAKVNGTLTQEENLADIAGLELAWAAYTAQEPKAKPAQQQGFFRAWAALWPQQLSPNEAARRLTADIRAPGRWRTNGPLSNLPAFGATFSCKAGQPMQRTDAEQIKVWR
>NZ_CP018756.1|WP_079222652.1|2754570_2756676_+|peptidase
MTRTPKIVLLTLAVSAALVGCGKTDTPAKDATASTPAATDQATTYKLDEAKLPAYNAFQASDLDSAMDACGAFGDYVNSKWLAANEIPGDRTSWGAFTILDERSVAVQHQLAEQLAQVKNPNHIEKIVGDLWATGMDEAKINAQGIEPLKGDLAAIDGLQDKAAIADYLRTSAAKGDNVLFGFGAEADFKNSAMNMAYASQGGLGLPDTTYYTDTKNADKLKAYQAHVAKVLELSGVAAADAAKQAEDVVKFETRLAKASKSRVDLSRNVELFYNPVTLADADKLTPNFSWTEFFKSQGVAAPEKFSLAMPAFHEEVSKALGDTDPSVWRAYLRFHTVDGASPYLADAFVQENYEFYGKTLNGQKEQKPRWKRVLGTIENDAGEAFGQLYVKVAFSPEAKAKMEELVKNLAASLKERIQGLSWMSDETKAKAIAKWETFTPKIGYPDKWRDWAGLQTQRDSYLGNVRAANEFNYKFNLSKVGKPVDKTEWGMTPQTVNAYYNPLQNEIVFPAAILQPPFFDPKADDALNYGGIGAVIGHEMTHGYDDQGARFGPTGNLEDWWTPADKKNFEGLTGKLVKQFDQYKVDGQAVNGHLTLGENIADLGGLATAYDALQKATAGKEDPKVDGFTRDQRFFFNWATVWRTKYTAENAKVRLATDPHAPAQFRAMGAPSNLPTFAAAFQCKAGSPMARTGDQQVVIW
>NZ_CP018756.1|WP_079222651.1|2751408_2754381_+|TonB-dependent-receptor
MTIHRTPGRHPLTCALLAGLMAAAAAPAFAQDAESTGNRAVDLDKVTVTGSRIARTGFVTPSPVTAISAEEIRGTGAVNIGDLMAKMPQLTPTYTMGNSTRFIGTAGLGLMDLRGMGTARTLVLVNGRRHVGASPGSTAVDVNTIPVEWIERVEVITGGASAVYGADAVAGVVNFIMKKKFDGFELRAQRGAASEGSFDRSFISFSGGKDFADGRGSAAIAMEYSTQGRYGRGDRAIGREFLTTVNNPDYDRTKPPSESNPQTILQGPGGNHALSYGGTFTLGAFRADGSNRYVFNPDGTFRKNRYDGTIVSANTCTNCDFADLNAVADLEPAFNRFSFNTAVNFDLNDDHRLFFEGKYTKTESEFFGQPTFDQVGTARALRIQRDNAYVTPELGALMDANGLSTLLVSRFNVDSGRRGENVERSTARAVLGLEGNLGADWTYEASANFGQTTIDRINFNNRIEERWQAGLDAVINPANGQIVCRSTLNPNAVNPYTGRAYSAALVAGCVPFNVMGNGKVSPEAAAWFNTNSLNQSKLKQQVFSASVANGSLFSLPAGDMGIAAGVEYRKEQSQENTDPLSAMGLTFLNAIPSRGGEYDTKEAFVETSVPLLADIPGIRRLNLDLAGRYSDYSTIGETKTWNVGLDWEVLSSLRFRASLAKAVRAPSIGELFNPQSQNFATINDPCNTLSTNSNRPSTAKDPALRAANCAALGIPSNWVDTYTATRPGVSGGNPDLKPERSKSVTMGFVWQPEFLDGFGMSMDYWRITLEDAIGSVTAQTNATRCVDSPGGVQNNSFCDMVVRASGTAGTPYSIIGWTALAENLAKSRRVGVDVEMDYRFQLAGGNTTLRLVGTRLIQSREWAFQAFPDEFTEYVTYYSDPRWRGQFNVNYDLGNFRAKWDMIYVDGNLRVTPDSYKSNPGSQSPIRNPSYLYHNMQVGYKIADSGVEVYLGVDNVFDKDPPVNYFGTDLGSSYYDMVGRYAYVGVTYKF
>NZ_CP018756.1|WP_079222650.1|2748152_2751032_+|TonB-dependent-receptor
MRTANRQIKPSRVPLTLAVLACLQAAPVFAQEAEPQQPTTTSSSASKNATNLDAISVTGSLIKRPEYETTSPVQVISIEKGIASGQFDTADFLQTSAIAAGSTQMNNQFGGFVVEGGTGVQTVSLRGLGANRTLVLLDGQRPGPAGTRGQVGSFDLNVIPQAILQRIEIVKDGSSSIYGSDALAGVVNLITKKSIDRPEMTYSMSVPQHGGGEQFSASIANGWNFEKGSIVAAAQWDRLNALTVGDRDFFSCAQDMVWGTDGKRIDREDRSILAGTDLAGCSTGNLYANTIINYNNSAIRYVPSPDGSTVGPFPGYRPRPRPTPTYANGGTAYYEDVLNYPFYHDQEVINQRERATLYAATDFSFDSFNWKTQFLYNRRETKAHSWRQFFPIVYSEAADDLFQVIMPFPSDQKITVDYFYGTTKFDGQFKSTESWAWEINAGYSRSSGDYGALAIDATRTGDLSYDNSGDMPVDYFNAGFLSGQRMDELVNAIGQYHTGNTVYEQTSANAILSGNLFTLPAGDVASAFGVEFRKYKINDTPSEFSRSGNIWGSSTADITKGTDKVKEAFAEVDVPLLKGIPGIESLSVNLSGRVFEYDSVSGSDKVWKTGVNWQIVPSLRVRGTMGTSYRAPGLYELYLGNQTGFLAQNQIDPCILWGDSNNDFLRANCGAAGIPETYAGGGGSATIYSGGGAGQLKPETSKAKTLGLVWTPTFANLNIALDYFDYDVRGEITQLDEYDIVFGCYGSAVYPNSFCNNLVRNSPTDPANPNQITTIYNQYVNINRERTRGYDLQINYDNDFAFGKLSAEAQVTYTLEDTYQLFDSAADSGFTTSDQVGYIGRPKTVGLASVSLERGDWAFNWQGVYNSSTQNKDLDRTFTYSGYQNATRDIKAGWQFRHNVSVAYNMDDWSLMVGVRNLFDKAPDLISNTAGTRYGNTPLYASQYDWYGRTFFARVSYKF
>NZ_CP018756.1|WP_079222649.1|2745941_2747963_+|S9-family-peptidase
MHVIPRFRLGTALALALAGTSAHAAPVPIEDLARLPALQSVSMSPDGKHLVALIPSPANPEETALASWDTDSLSGGPKVVTPSGDRMKFIAAAALKSDRILAVGRQEWTGQLGGCGEGSVSGATKTFVVKTYLTDTTQKDFGEAFADNTRKLGVSEQTQRCLELGGTASLVNMLPLDPDRVIIRQLSEISLTANYYLYNLKTKETELLFRGGTRAQPALFDARTGKVLAKAQIEPVSGDYEQQVLILDPSSGQFVLQKPLLSKLSNRHSVELAGVDDATGKYYILTDLFSDKVQAHLYDAKLQKFDPEPVLANPNFSIASLVFSTQPKTFNQVVGFTIDGPSAQTVYVDPTLKSIQDTLKQAAGGRQVEIARYNDDFSRILFRAVGPDAPTSYFLLLDRKNVVSLGSERPWIAKGATGEERWVTYKARDGREIPAILDLPQGWKDGDPAPPAIVNPHGGPWARDYVQWDASGWIALLTSRGYAVLRPQYRGSSGLGRELWIAGDREWGQKMSDDNDDGAAWLVSQGFAAKDRIAIFGYSYGGFAAAAATVRPNSPYQCAIAGAPVTDLARLGTSWSDNRLQRILQGQTVKGMDPMRNTASANIPVMLFVGDRDVRTPSFHAQGFYDAVKGKVPAKFHLIADQQHSMPWYPRQQRETLGLIESFLKNDCGPGGL
>NZ_CP018756.1|WP_079222648.1|2744900_2745755_-|iron-sulfur-cluster-carrier-protein-ApbC
MNSPARRPHASQVQKGLSPHARIRNVIAVGSGKGGVGKSTTSVNLAVALQQLGARVGVLDADIYGPSVPAMLGLSGRPESPDNKSIEPMRAFGVDTMSIGYLVEDETPLIMRAPRATAALTQLFEDTLWDDLDYLLIDLPPGTGDIQLTLVQKIPLAGAVIVTTPQDIATLDAKKALKMFEKVEVPVLGIVENMAVHTCSNCGHVEHLFGEGGGERMAAQYGVPLLGSLPLQIDIREQGDAGSPITVAQPESTAAQAYRRAAERLVDEVGKRPRASIQILSSLL
>NZ_CP018756.1|WP_079222658.1|2766786_2767461_-|rhomboid-family-intramembrane-serine-protease
MFPRLPTVTKALLIANAILFLLQQPFLLGMQTFEPFMLQPWQQGFDAFSPGGNFQPWQLLTYGFLHGSFGHLFFNMLAVFMFGAPLEQTWGEKRFLLYYLVCVAGAGVCQLLVGTLLENPATVLGASGGVFGLLLAYGMLFPNQRVMLLFPPIPMKARTFVILFGVGELVLGMTGWQPGVAHFAHLGGMLFGWLLIRYWRGQPPFNKRRPPGPPKRPNHLRSVK
>NZ_CP018756.1|WP_079225314.1|2767554_2767863_-|MGMT-family-protein
MAVIRAIPPGQVLGYGQVAMRAGLPGRARLTARILGQNEDPGLPWHRVLRSDGRIAMAEGSAGWREQSQRLRAEGVVVENGRVRMPAIDPAAALDAAIWGPG
>NZ_CP018756.1|WP_079225312.1|2767889_2768810_-|DMT-family-transporter
MSSPSPRIATASPRIALGGIGLAAVGAIAASGKAIIVKLGLRHGVDATTLLALRMLMALPLFVLMALWSARRTEPLSWADRARVLWLGLTGYYLSSLLDFQGLQYISVTLERLILYLNPTLVLLINVLLARQRPGRWQVAALALSYLGVLLAFGHDLQREGGQIIVGSLLVLGSALSYALYLFGSGQVVARIGAVRLTAYASCVASALVLLHFAITHPLPLLWQAPAAVQWLSLVNATVCTVLPVLAIMLAVQRVGSSLAAQVGMLGPVSTIVMSLWLLDEPMGPAQIAGTVLVLIGVLLVTRLRR
>NZ_CP018756.1|WP_079222659.1|2768973_2770332_-|glutathione-disulfide-reductase
MSTASFDYDLIVLGGGSAGLAGAIRAAQHGKRVALLEPGALGGTCVNVGCVPKKAMWLAADLHERIGLASAMGFDVPARPALSWKELVIHRQAYISNIHTSYNKRLDETGVVRIPARGHLVDAHTVACSDGVRYSAEHILIATGAHPQRPDIPGAALGLVSDDFFDLRSAPAEVAIIGGGYIAVELAGLLQALGSRVSLLVRGARLLERFDYELTDQLAENLKQQGVRIHFDYRLRELQREGERVRAFGHDGPLDSVFDAVFFATGRRGNSRDLGLEALGIGIGEHQQVEVDEWQTTAVPSVHAVGDIAGKVGLTPVAVAAARRLMDRLFGGRPSAKMDYSNVASVVFSHPPLGAVGMSEEQARACFDQVTVYHSRFRPMLQALANGTQRSLFKMVCAGADERVVGIHLLGEAADEILQGFAVAVKMGATKAQFDDTVAIHPTSAEEVVLMR
>NZ_CP018756.1|WP_079222660.1|2770450_2771695_-|DUF418-domain-containing-protein
MADLPAGCPVNAASLSLQPVASGERIAVLDVLRGVALLGILLMNIEAFSGPLDLAFTGIDARWHGLDYVADAFVYIFVQGKFFTLFSLLFGAGFAVMAQRAQAAGREFTPFYLRRSLGLALIGLCHALLVWSGDILVLYALVSLPLLACREAPRSWLPWMGIVVYLAGVSMMLLIGAMVTLSPAQDLQKMVVDAQQAIDQQRLVYGQGSWLQGNVQRLHEFGSSLGALVITGPEVLGMFLIGSWFAGSGALAEPDRFPRLYAGLRWVALPLGLLVTLAGVLWKPYLAPGQYTLETTAVMSLVSVGAVPMCLGYLAWIVHWRARLGWLAPAGRMALTHYLAQSLACTWLFNHYGLGGFDLMPRAWQVVFALLLFALQVGISHWWLRRFRFGPMEWLWRAMTYRQWPPMRREVAQG
>NZ_CP018756.1|WP_079222661.1|2771794_2772277_-|peptidylprolyl-isomerase
MKIEKDRVVRFHYTVSEVGQAPIESSKDRGEPLSILIGHGNIIPGLENAMMDKEAGATFDVDVTAADAYGERREGLSQRVPKKHFGNAKLVPGQQVVLQTNFGPRAVTVQKVGMSVVDVDLNHPMAGKDLHFDVEIVEVREAAKEEIDHGHVHGDGGHQH
>NZ_CP018756.1|WP_079222662.1|2772388_2772928_+|C40-family-peptidase
MHNTPVSSGLRRILAPALLLALPLLLAACGGGKAVRPATPPPSAHWPATTPDNPEAANSVLMRAISLVGTPYRYGGNTPDSGFDCSGLVTYVYREMVDLKLPRTSRDLAAVQGPKIDPQRLATGDLVFFGSRGNVTHVGIYVGEGRFVHAPSTGGTVRLDSLSGAYWKDHYTGAKRVLR
>NZ_CP018756.1|WP_079222663.1|2773059_2773830_+|C40-family-peptidase
MTTDDLQGQGQTAASSRSVRPLFLGLALCLTSLPAWSQSAPTKTDATPATVAETARPAAKADAAAPQRSRADAAASATLAALLPHLAANDTIPLMDRSAMVAGDLSRLLANYDTSSVATGAVVGNLDDNGKVQSLLRRAMTLLGTPYRWGGSNPDSGFDCSGLVGYVFRSALGIELPRVSREMAHDNNAELINDRAALAAGDLVFFGRKGRVDHVGIYVGEGRFLHAPSTGKDVRVDTLLTGYWGNKFMQARRVEL
>NZ_CP018756.1|WP_079222664.1|2774072_2775425_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MAASLQVPSRCVIWFGQPLAGEREALAAAGWQLRCVSPSPAMAVGLRGRDHLVAVLDLRHLDAEALGPLLPWVEQHHHLPWLAVLPAGLDAPPPSWAPLLRACQDQFTLPRELQDLLTAMQRDCGEEDPPTASMRDGGGLPALIGDSQALLAVRAALHKFAPVELPVLVTGETGTGKELAAQALHALSGRAGRPFLAVNCGAIPASLVQSELFGHERGAFTGAAQRRVGLFETADGGTVFLDEVGDLPADAQTSLLRVLQEGTLERVGSNQPLRVDVRVLAATHVDLEQAVAQGRFRRDLYYRLNVLRLPMPALRDRGNDVLLLAEHFLRSFRNRHPGRARGFDPGARLAMRHFDWPGNVRELLNRVQRAAIVSEHELISASDLDMADAETPAPRAVLQDARGQVERDVLLRTLKMHGYNVSACARHMQVSRVTVYRLCRKHRLELPPER
>NZ_CP018756.1|WP_079222665.1|2775543_2776839_-|transporter
MHTYLRLTPLALAALAANAFAQEPATEAKDGADVQALISQLEQLKANYAQEVRRLRELDMQVQAMQARLSGRAGGATTPAAPLAPAAAAAAPPSSEGYASTAAEAQQAKQEARRSVDDVKQQQAALFSRRFTLENSLTYARYDRKQLSLNGFLALDAIFLGNIAIENVESDSLTYNLAARWGVSPNLTLNMDVPYLARRTVYQKGGAGGAAAAIAQEETNGNGLGDISASANYRLFGERGWRPETVLTGGVTAPTGRAPYGLDWKVLERDDDDYIRFAVPREQPTGNGVWQANLGVSMVKTADPAILFANAGYIHSFPRGFDDIDSNPDTVNPGDVKLGGSVYFGAGVAFAFNERTSLSISFSDKISARASTRFQGGQWVKVIGSDANAASLNLGVTYALNQHATMVTLLGIGLTPDAPDFTLSFKVPYML

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Crispr_ID: NZ_CP018756_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_20

2821441-2821546

Orphan

Consensus_repeat	Method
CCCCGTGCCGACCAACGGTCGGCACCCACCACCAGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_20

>merge|NZ_CP018756|20|2821441-2821546|CRISPRCasFinder
CCCCGTGCCGACCAACGGTCGGCACCCACCACCAGCCGCGATCCACCCACCACCAGCCGCAATCCGGCCCCGTGCCGACCAACGGTCGGCACCCACCATCAGCCGC

>NZ_CP018756|20|19|2821441-2821546|CRISPRCasFinder
CCCCGTGCCGACCAACGGTCGGCACCCACCACCAGCCGC	GATCCACCCACCACCAGCCGCAATCCGG
CCCCGTGCCGACCAACGGTCGGCACCCACCATCAGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222704.1\|2821821_2822271_+\|DUF2147-domain-containing-protein	unknown	unknown	gnl\|CDD\|378304
NZ_CP018756.1\|WP_079222708.1\|2826224_2826572_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100007
NZ_CP018756.1\|WP_174208733.1\|2831469_2831643_-\|oxidoreductase-like-protein	unknown	unknown	gnl\|CDD\|370696
NZ_CP018756.1\|WP_079222710.1\|2829430_2830777_-\|virulence-factor-family-protein	unknown	unknown	gnl\|CDD\|226455
NZ_CP018756.1\|WP_079222698.1\|2815702_2816164_+\|DUF4442-domain-containing-protein	unknown	unknown	gnl\|CDD\|373120
NZ_CP018756.1\|WP_079222705.1\|2822373_2824455_+\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234655
NZ_CP018756.1\|WP_079222696.1\|2812267_2813968_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|226705
NZ_CP018756.1\|WP_079222699.1\|2816165_2817443_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|260091
NZ_CP018756.1\|WP_079222707.1\|2825146_2825560_+\|Rnf-electron-transport-complex-subunit-RnfB	unknown	unknown	gnl\|CDD\|181550
NZ_CP018756.1\|WP_079222702.1\|2819090_2821031_+\|DUF885-family-protein	unknown	unknown	gnl\|CDD\|227142
NZ_CP018756.1\|WP_079222711.1\|2830855_2831473_-\|DUF998-domain-containing-protein	unknown	unknown	gnl\|CDD\|377627
NZ_CP018756.1\|WP_079222701.1\|2818198_2818996_+\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|376842
NZ_CP018756.1\|WP_079222709.1\|2826764_2829329_+\|bifunctional-lysylphosphatidylglycerol-flippase/synthetase-MprF	unknown	unknown	gnl\|CDD\|225451
NZ_CP018756.1\|WP_079222700.1\|2817518_2818202_+\|DUF502-domain-containing-protein	unknown	unknown	gnl\|CDD\|225480
NZ_CP018756.1\|WP_079222706.1\|2824530_2825121_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|319796
NZ_CP018756.1\|WP_079222703.1\|2821027_2821435_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319940
NZ_CP018756.1\|WP_079222695.1\|2811299_2812160_+\|thioredoxin	unknown	unknown	gnl\|CDD\|225660
NZ_CP018756.1\|WP_108747136.1\|2825810_2826167_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222694.1\|2810536_2811136_-\|DUF998-domain-containing-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222697.1\|2813964_2815590_+\|CHASE2-domain-containing-protein	unknown	unknown	gnl\|CDD\|215016

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222704.1\|2821821_2822271_+\|DUF2147-domain-containing-protein	gnl\|CDD\|378304	pfam09917, DUF2147, Uncharacterized protein conserved in bacteria (DUF2147). This domain, found in various hypothetical prokaryotic proteins, has no known function.	6.10163e-36
NZ_CP018756.1\|WP_079222708.1\|2826224_2826572_-\|RidA-family-protein	gnl\|CDD\|100007	cd06150, YjgF_YER057c_UK114_like_2, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.68569e-53
NZ_CP018756.1\|WP_174208733.1\|2831469_2831643_-\|oxidoreductase-like-protein	gnl\|CDD\|370696	pfam09791, Oxidored-like, Oxidoreductase-like protein, N-terminal. Members of this family are found in the N terminal region of various oxidoreductase like proteins. Their exact function is, as yet, unknown.	7.63567e-10
NZ_CP018756.1\|WP_079222710.1\|2829430_2830777_-\|virulence-factor-family-protein	gnl\|CDD\|226455	COG3946, VirJ, Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion].	2.01917e-115
NZ_CP018756.1\|WP_079222698.1\|2815702_2816164_+\|DUF4442-domain-containing-protein	gnl\|CDD\|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	2.88661e-21
NZ_CP018756.1\|WP_079222705.1\|2822373_2824455_+\|methionine--tRNA-ligase	gnl\|CDD\|234655	PRK00133, metG, methionyl-tRNA synthetase; Reviewed.	0
NZ_CP018756.1\|WP_079222696.1\|2812267_2813968_+\|FecR-domain-containing-protein	gnl\|CDD\|226705	COG4254, COG4254, Uncharacterized protein conserved in bacteria [Function unknown].	9.09286e-34
NZ_CP018756.1\|WP_079222699.1\|2816165_2817443_-\|hypothetical-protein	gnl\|CDD\|260091	cd14233, GAT_TOM1_like, GAT domain found in target of myb protein 1 (Tom1) protein family. Tom1 and its related proteins, Tom1L1 and Tom1L2, form a protein family sharing an N-terminal VHS (Vps27p/Hrs/STAM)-domain followed by a GAT (GGA and TOM1) domain, both of which are also conserved in Golgi-localized gamma ear-containing Arf-binding proteins (GGAs). In contrast to GGAs, the Tom1 family proteins bind to ubiquitin, ubiquitinated proteins, and Toll-interacting protein (Tollip) through its GAT domain, but do not associate with Arf GTPases through its GAT domain nor with acidic cluster-dileucine sequences through its VHS domain. In addition, the Tom1 family proteins recruit clathrin onto endosomes through their C-terminal region. However, in the C-terminal clathrin-binding region, Tom1 and Tom1L2 are similar to each other, but distinguishable from Tom1L1. The yeast S. cerevisiae does not contain homologous proteins of the Tom1 family.	0.00194818
NZ_CP018756.1\|WP_079222707.1\|2825146_2825560_+\|Rnf-electron-transport-complex-subunit-RnfB	gnl\|CDD\|181550	PRK08764, PRK08764, Rnf electron transport complex subunit RnfB.	5.99067e-77
NZ_CP018756.1\|WP_079222702.1\|2819090_2821031_+\|DUF885-family-protein	gnl\|CDD\|227142	COG4805, COG4805, Uncharacterized protein conserved in bacteria [Function unknown].	4.07794e-171
NZ_CP018756.1\|WP_079222711.1\|2830855_2831473_-\|DUF998-domain-containing-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	0.00012267
NZ_CP018756.1\|WP_079222709.1\|2826764_2829329_+\|bifunctional-lysylphosphatidylglycerol-flippase/synthetase-MprF	gnl\|CDD\|225451	COG2898, COG2898, Uncharacterized conserved protein [Function unknown].	0
NZ_CP018756.1\|WP_079222700.1\|2817518_2818202_+\|DUF502-domain-containing-protein	gnl\|CDD\|225480	COG2928, COG2928, Uncharacterized conserved protein [Function unknown].	3.04461e-61
NZ_CP018756.1\|WP_079222706.1\|2824530_2825121_+\|HAD-IB-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.81113e-48
NZ_CP018756.1\|WP_079222703.1\|2821027_2821435_+\|VOC-family-protein	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.40666e-72
NZ_CP018756.1\|WP_079222695.1\|2811299_2812160_+\|thioredoxin	gnl\|CDD\|225660	COG3118, COG3118, Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones].	1.33473e-85
NZ_CP018756.1\|WP_079222701.1\|2818198_2818996_+\|queuosine-precursor-transporter	gnl\|CDD\|376842	pfam02592, Vut_1, Putative vitamin uptake transporter.	2.55059e-41
NZ_CP018756.1\|WP_079222697.1\|2813964_2815590_+\|CHASE2-domain-containing-protein	gnl\|CDD\|215016	smart01080, CHASE2, CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE2 domains are not known at this time.	6.97088e-60

>NZ_CP018756.1|WP_079222703.1|2821027_2821435_+|VOC-family-protein
MTRAATGGLLGIHHAAVICSDYARSKDFYVRILGLRVLAENHRAARDSWKLDLSLPDGGQLELFSFPAPPPRPSRPEAQGLRHLAFRVAALEPFIQRLAEHGVACEPIRVDEYTGARFTFFADPDDLPLELYEVG
>NZ_CP018756.1|WP_079222702.1|2819090_2821031_+|DUF885-family-protein
MPYPTRALAAAIAALFLFSAVPSAEAAKKKASRPAAAQTRQAAKPKAKPARATPARGSSTRRAATRPVAPARAVPRQVQLERLYDEYWDASMRLNPLQATFQGDARYNDQLPNILSAAWRQQSHDFTTEWLGKVEKVGSDGLQGQDLLSYEIFVRDARASLAAERYPSWMMPISQYYNIGSIMAILGAGAGAQPFNTVKDYDTWSRRSLGIPDLFNQAIDNMRQGMKAGVVQPRDLMEKVLPQLDAVITPTAEESIFWSPIRTMPSDIPAEEKARISAEYKRMIELRIMPSYRALRGFIATEYLPATRSSSGLGALPDGQGWYANLIVQTTASDQTAAQLHALGEQRVQELSAQIAAVMKDNKLRGSQAKLLKNMRTDRQFQYGDANALINRYRQLQQQVDARLPQVLDTLPKDRLEVRAVEPDRALTAAAAAYQPGQPGQPGVLYVNTRDLPSRKRWSVPVQYLHEAIPGHHVQLGLQQELAKLPRFRRLGGDLAFVEGWGLYAETLGDDLGVYTDPYDRIGYLYSRLLRAARVVADTGVHSQGWSKQQAVNYLQKAVDMSEDDASAEVERIMAQPGQALSNVAGLSRILALRDKARARQGAAFDLRRFHAEVLKDGSMPLDVLERKVDRWLDQPAATAPATATP
>NZ_CP018756.1|WP_079222701.1|2818198_2818996_+|queuosine-precursor-transporter
MSGTPSDAPYARPLQDRAVLLFIILATFFCGNAVLAELIGVKIFALEDTLGIDALNWNLFGQTGSLSFTAGTLLWPVVFIMTDSINEFFGKRGVRFISWLAVVLIAYGFLFAFAAISLAPASWWVTSMDAHGVPDYQAAFAAVFGQGMWTIAGSLVAFLVGQLIDVAVFHRIRQATGERHVWLRATGSTAVSQLVDSFVVIWIAFVLGPQKWPTSLFLAVSSVNYVYKMGFAIALIPLLYLMRRAITRYLGEPRAAQLRAAAAAD
>NZ_CP018756.1|WP_079222700.1|2817518_2818202_+|DUF502-domain-containing-protein
MSLEAPALVPRPSLQRLFLTGLLTLLPIWLTWVVVKFVFVLLSGISSPLVVPLSEQIATSFPHYLGWVHAEWIQDTIALLATLLVILAVGVASRRVVGQRLLRWVGAIIKRIPLASIIYDSAKKLLDMLQTEPGSTQRVVLIDFPHRDMKSVGLVTRVIKEQGTDRELAAVYVPTTPNPTSGYLEIVPVELLTPTDWTVDQAMSFIISGGAVAPASVPFTRAGERPE
>NZ_CP018756.1|WP_079222699.1|2816165_2817443_-|hypothetical-protein
MLRILRGVGWALLGLLVLAVLVWTLSRFWPLPPAQREQVRWLEDVRPLPGKDGFALLWTLPFDGLDRAQREAALAEDVRHWQVDPAPDRTDSVLAATHPEVKVDSQGYCRSTGESCLAKVRADTAQFRAAHAGHEGLHERLDALADADRFDTPFLPSGSPGIYPWPRYQTLMDASGVHALAFVRGDVPAALAGSCRSVQVGRRLMRGGNALIDSMIGAAMVRANVYLLAEMLAELPPGQVLPAACESALQPMEAAEQSLCRAMQGEFAMSRAAIDASLQQTGAVLMLDREHTLGRFALNLGWACDPAATRLLVADQPVATGSVRSRDFSCLSNRVGCVLSDIAAPTYRSYAARSQDVAALLRLLGAQRWLRQQADAPEQALQRLPAQWRSSTRTPVLSADGRHLQVPRREADMLDGSEPVLSVPL
>NZ_CP018756.1|WP_079222698.1|2815702_2816164_+|DUF4442-domain-containing-protein
MKASTFRLGINLWPPFLFTGIHVTRITPDYRQIEVELRMRPWNRNYVGTHFGGSLFAMTDPFWMLGLMHTLGRDYYVWDRAGAIEFLKPGRGTVRTAFHIDEAVLDELRSQAANGEKVLRWFSNDVVDASGEVVARVRKQVYVRLKPQARGAP
>NZ_CP018756.1|WP_079222697.1|2813964_2815590_+|CHASE2-domain-containing-protein
MRRSPLPWSRRILLALLAGIATAVVSHGQFLWRQDEAAYDLLVGDWDYRPDPSVLIVAIDEESLQRIGQWPWPRSVHARLLDRLTDAGVERVALDLMLSEPDRRDARQDAELAAAIRRNGRVVLPVLAAPAAGDRLAEELLPIPLIAASAAAIGHSDVEVDGDGVARGVYLRAGIGQPHWPALGLALSGLPAQRMHGLADPAPALESPYQWRRDDYVRVRYAGPPERLPHVSYADVLDGQVDASLLHGRRIVVGMTASGIAPRLLTPTTREYWMSGSEYQANIASMLLQDKQINVLPRIAQDVLSGLMAALCVMLLGLRLPWLAALCSLPLAPLLGWLLLRVGNLWWTPASALLGVLLILLVWAVWRISAWHRQANRDALTGLGNRLRFEQALQEECDAARRSGKPLSLALIDVDHFKHHNDRHGHQAGDGVLRDVARLIAAHARRPRDMAARYGGDEFALVLPDTPADGARLVVEDLIAGVRALPPPGDGRGAGITLTIGVYTRVPDGSLHPHHFVEGADAALYRAKDNGRDGYAMSGEV
>NZ_CP018756.1|WP_079222696.1|2812267_2813968_+|FecR-domain-containing-protein
MGSCSCAPAQPGQHSVTVGRSSSSLARRFAALLCALLLLPGLAAAQDWNYRVRPGDTLWDLGGLYLKADVPWQQLQQHNRIDNPYRLPPGGLLRFPVSWLRVEPAPARVLAVRGTVKLAAANGSATRALLAGERLHIGDTVQTAADASVTLEFADASRLQLREHSRLRLDQLSRYGRTGMVDTRVRLQQGRASNRVTPARGPASRYIIDAPAATSSVRGTVFRVSAGDGTQVGATEVLEGRVQVGNPHGQRLVRPGQASRSASADAAPEAVSALLPPPRLRSDATTLAPLPARLAWEPVAAADHYRVEVVLAATPEILLFAATTAGTSLVIDDLPPGALRLLLRAVDAQGVEGLDASADFLLSDQPPPPLTVSPLHGQAINSDRPRFRWTQAPGASSSVLQIAGEPRFLQPLQQQASTGTDLRLATPLPPGQYFWRIASRDSQGHQGPFGQALPLQLTDDPVDPALQPPEAAHGELTLRWQAGSEGQRYRVQVDRRGDFKAPLVDETLAQPQVSFKRPWRGTLHVRVQYIDDDGHAGPFSPAQQVKLPCRLCYGAGGSALLLWLLL
>NZ_CP018756.1|WP_079222695.1|2811299_2812160_+|thioredoxin
MTETTTHVFDATTATFEAEVLQKSLQTPVLVDFWATWCGPCKTLGPMLEKLAAEYNGAFELAKVDVDAEQQIAAAFQIRSVPTVFLVKGGQLVDGFPGAIPEGQLREFLAQHGIVPADIGDTVAEDEAPLDPQAQVDVLRAQIAAEPDKDELKLDLALALLQVGGVDEAGTLIDALPANLATDDRAVRGRARLAFATALKDAPSAEALDARIAADGKDLQARHLRGVQLLLGGHDEAALEQFLEMLRIDRTFAEGLPRKVLIDAFNVITDEDLVGRYRRKMASLLF
>NZ_CP018756.1|WP_079222694.1|2810536_2811136_-|DUF998-domain-containing-protein
MSVLWLDRWLGLLAAMLFVLAVLGFGAGLAGYAQAVHPVALLGAQGVPHALAFNLLGLVLPGALAVVVAERLRRQLPVGAGWAPRVGSQMLLLAGLAFAAMGLLPLDPEDLHGGASQLHASAWMVWVLGFVVGTLMLGIPRLRGGHGRAMALLALGCGALAGLAAFALQGVLPAPLAQRLAFACWAAWLALALPLSRRH
>NZ_CP018756.1|WP_079222704.1|2821821_2822271_+|DUF2147-domain-containing-protein
MRKTFKTLLLALPLCLAALSAQAADSAAGRWKTIDDKTGKVKSIVEISQAANGGLSGKVVEILQSDKGPNPVCDGCEGANKNKPVKGMTILWNLSQDKGSHSKWSGGTILDPANGKTYKSKLELQPGGGKLDVSGCIAFICRTQTWVRE
>NZ_CP018756.1|WP_079222705.1|2822373_2824455_+|methionine--tRNA-ligase
MTRTALVTTALPYANGPLHLGHLVGYIQADIWVRARRMSGGKAWFVCADDTHGTPIMLAAEKAGVTPEAFIANIQAGHERDFAAFGVAFDHYDSTNSAANKALTEQFYLKLEAAGHISRRSVAQFYDPAKGMFLPDRYIKGICPNCGSADQYGDNCEVCGATYNPTDLKDPKSVISGATPEIRDSEHFFFEVGRFEGFLRSWLAGDVALPGVKAKLMEWLDAEGGLRAWDISRDAPYFGFEIPGQPGKYFYVWLDAPIGYLSSFQTLCGTLGEDFESHLREGTSTELHHFIGKDIVNFHGLFWPAVLNGTGHRAPTRLHVNGYLMVDGAKMSKSRGTFVMARTFLDAGLEPEALRYYYAAKTSGGVDDLDLNLGDFVARVNADLVGKFVNLASRCAGFISKRFDGLLAAQLPDAPQYQRFVDGLAPIREAYERNDPAAAIRLTMTLADEANRYIDEVKPWVIAKQEGADAQLQAVCSQGLNLFRVLVTALKPVLPATAAQAEAFLAAPVNDWTALAQPLLGHRIAEYTPLFTRIDPKKIDAMIDASKDTLQPAAAAAPAAKTEAVKPAAPAPAKDDAKSADAPAYIGIDDFAKLDLRIGKVLVCEFVEGSDKLLRFELDAGELGKRQIFSGIRGSYGEPEALVGRSVVFIANLAPRKMRFGLSEGMILSAGFDGGALALLDADSGAQPGMPVR
>NZ_CP018756.1|WP_079222706.1|2824530_2825121_+|HAD-IB-family-hydrolase
MELALFDFDHTVTTCDTYGRFLRRVATPEQLARAWWKVGPWLLAYRLRIISAERIRARVTRLTFSERHADDIATLAAGFAREVLPEVVRPEMLEQIRWHKEQQHTVVIVSGSLDLYLKPWCEQLGLQLICNRLESQDGRLTGRYAGGDCGPRKVEHIRRQFDLSRYLRIHAYGDSYEDRPMLALAHERWYRGRPLK
>NZ_CP018756.1|WP_079222707.1|2825146_2825560_+|Rnf-electron-transport-complex-subunit-RnfB
MSLIPPLTERLDRLLPQTQCGQCGYDGCRPYAQAMARGDVGVDRCPPGGDAGARALAQVLGVPAVPFDRTRGTHKAPQVALIVEADCIGCTKCIQACPVDAIVGGAKYMHTVIADLCTGCELCIPPCPVDCIDLVPV
>NZ_CP018756.1|WP_108747136.1|2825810_2826167_+|hypothetical-protein
MTPSDLSGACASDATDAADEIQCDPARLMALLQKISAGAPAGGFLWPEGCFLSGGHVGLTEADRILAGLRVVQEVVLAAERSRSHDDADDYVGDRFMASLMQACIALSAHAASRIHSQ
>NZ_CP018756.1|WP_079222708.1|2826224_2826572_-|RidA-family-protein
MMERYDIGPRMSEMTVHNKVAYLSGQIPEDTSQDITGQTRQVLAEIDKLLALVASDRQHVLRAEVFLADIADFDGMNKAWDEWVVEGATPARATFEAKLAHAEWKVEIVITAAVP
>NZ_CP018756.1|WP_079222709.1|2826764_2829329_+|bifunctional-lysylphosphatidylglycerol-flippase/synthetase-MprF
MTHAPDSTTASHTPAWKRVLTIVIPLLILALALHGLANEFDEHGYRAIRDAFHKLTGAQIALTVLLGLASYACLIGFDAIGLRRSGIRVHPARVGITAFLAHTLGQTVGFAALTGGAVRLRGYRSAGLDLAQIGQVVLMSTLGFVFGAWLLIGVALCMEPAAAALALPLDPAAVRVVGILALLAYAATVLLVGRNGRQFRIFGHGLWLPDRRTMLGVTVLSVIELVLASAAFYVLLPDSTPTGLPGFVGLYLVAVLAGLVSTVPAGLGVFEWSLLKLLPQVAPAAVLAAALIYRVTYYVLPLLLATLLALAPALRQPLQASAGATRAGWHALRPWLPQIIALAAFSIGAALVIDGTLPTPRRHLLNASLPILETSHLIGSLGGVALLLIGQGLARRSHAAWMLAMAVCVVTPLPLWLRGGQPLIAVSALLVAMALWAARREFYRQGALLDEAWSWPWLRNLGLVLVAVTWLLFFTYSHVEYQNELWWQFAVSGNAPRALRALLVVAIALVMFGLARLLHSTRTPLPAADDATLQALAPVLAGATDTQACLVLTADKAVLRDEAKQGFVMMQRYGGSLIAMGDPVGPPEVARALIWRFREEADRLGLRPVFYQVGEAYWQTYLDLGLGLVKLGEEAMVPLHDFGLEGRERADLRQAWNRGKRSGLSFRVAPVEEIPELLPRLHAISNAWLDDKAGDEKGFSLGSFDPGYLVRFPVALVEAEGEIVAFANLWQAPAGAELSVDLMRHVNEAPKGTMDFLFIELFLWGRAQGYARFSLGMAPLSGLAQHRLAGRWNRLAGLLARHGERFYGFSGLRRFKSKFDPQWRPRYLAAPGGMHLPAALLDATRLISLDPRRG
>NZ_CP018756.1|WP_079222710.1|2829430_2830777_-|virulence-factor-family-protein
MKRAGLGRAVGVVLALAALPAMAAANVQQFSHGRFDQIPVHMPAGTPQRVVIWFHEPTAGGDTSRLPIEALRADGALVAAVDISHLRGVLKREGNPTCSFGAGDVENFSRWLQASLHLPGYHLPLVGGDGEGAEMAYTLAAQADTQVFAGLLTTGFCPDHSHERMVCGDGVKHNRLQPTDLNFPWLSAAGGNACKAGQASAFVQQVAMAREFKRTARGDASPGLVAAARVVGAQAGVSLAPPPDALKGLPVVEVPASGSGDTLAIFVSGDGGWAGLDKNVASSLSEHGVAVVGIDSLRYFWSERTPKGFAADLQRIIAHYKQQWRRDKVMLVGFSQGADVLPATINQLDAGTRDGIERIALLSVGRKADFEFHVSNWLGGGGGGLPIAPEVAKLPAAKTLCVYGKDDEDALCPDLPANDGVQKVKLPGDHHFNGDYDRLAEVILKGGA
>NZ_CP018756.1|WP_079222711.1|2830855_2831473_-|DUF998-domain-containing-protein
MTRARPAALLAIVALLLFIATAVWTQFARADLDWVQATLSLYLHGPWGLALRSAYCLLALAIAVLGIALYRHSTGPRRSAAAPLLFTVAALGLATVSIGDSWLPSATPLLAPLVHGLAANTAFLCASVGMLLQAWYLRREPGWQRSAALLWGWAWLAFVLLWLHVLWRGGPPRGLGQKTVIVVIAGWLLWLAFALYRRGQRSASD
>NZ_CP018756.1|WP_174208733.1|2831469_2831643_-|oxidoreductase-like-protein
MPAPDPDPRPLPPEEPGPNECCGSGCPLCVLDLYSDELQRYRKALSEWQARHPQETP

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Crispr_ID: NZ_CP018756_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_21

3062380-3062470

Orphan

Consensus_repeat	Method
AGCGTGCGAACCAACGGTTCGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_21

>merge|NZ_CP018756|21|3062380-3062470|CRISPRCasFinder
AGCGTGCGAACCAACGGTTCGCACCTACCACAGCACACCGGTAGCGCCGGGCCATGCCCGGCGGAGAGCGTGCGAACCAACGGTTCGCACC

>NZ_CP018756|21|20|3062380-3062470|CRISPRCasFinder
AGCGTGCGAACCAACGGTTCGCACC	TACCACAGCACACCGGTAGCGCCGGGCCATGCCCGGCGGAG
AGCGTGCGAACCAACGGTTCGCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222892.1\|3064883_3065402_-\|peptidoglycan-associated-lipoprotein-Pal	unknown	unknown	gnl\|CDD\|274307
NZ_CP018756.1\|WP_079222886.1\|3060481_3060850_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222894.1\|3066965_3068027_-\|cell-envelope-integrity-protein-TolA	unknown	unknown	gnl\|CDD\|274303
NZ_CP018756.1\|WP_079222897.1\|3069259_3069691_-\|tol-pal-system-associated-acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|274304
NZ_CP018756.1\|WP_079222890.1\|3063248_3063950_-\|7-carboxy-7-deazaguanine-synthase-QueE	unknown	unknown	gnl\|CDD\|275145
NZ_CP018756.1\|WP_079222891.1\|3064061_3064880_-\|tol-pal-system-protein-YbgF	unknown	unknown	gnl\|CDD\|224643
NZ_CP018756.1\|WP_079222889.1\|3062504_3063170_-\|7-cyano-7-deazaguanine-synthase-QueC	unknown	unknown	gnl\|CDD\|284031
NZ_CP018756.1\|WP_079222883.1\|3057019_3057373_-\|DUF2750-domain-containing-protein	unknown	unknown	gnl\|CDD\|378546
NZ_CP018756.1\|WP_079222885.1\|3058791_3059643_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225375
NZ_CP018756.1\|WP_079225349.1\|3057369_3057798_-\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NZ_CP018756.1\|WP_079222882.1\|3056168_3056591_+\|response-regulator	unknown	unknown	gnl\|CDD\|333815
NZ_CP018756.1\|WP_079222893.1\|3065465_3066785_-\|Tol-Pal-system-beta-propeller-repeat-protein-TolB	unknown	unknown	gnl\|CDD\|179892
NZ_CP018756.1\|WP_079222888.1\|3061361_3061847_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222887.1\|3060928_3061246_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222895.1\|3068016_3068445_-\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
NZ_CP018756.1\|WP_079222898.1\|3069680_3070721_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_CP018756.1\|WP_079222881.1\|3055630_3055936_-\|zf-TFIIB-domain-containing-protein	unknown	unknown	gnl\|CDD\|226331
NZ_CP018756.1\|WP_079222884.1\|3057817_3058762_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225375
NZ_CP018756.1\|WP_079222896.1\|3068469_3069249_-\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
NZ_CP018756.1\|WP_079222880.1\|3055043_3055556_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222884.1\|3057817_3058762_-\|alpha/beta-hydrolase	gnl\|CDD\|225375	COG2819, COG2819, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	2.24384e-35
NZ_CP018756.1\|WP_079222894.1\|3066965_3068027_-\|cell-envelope-integrity-protein-TolA	gnl\|CDD\|274303	TIGR02794, Protein_TolA, TolA protein. TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	3.22076e-13
NZ_CP018756.1\|WP_079222897.1\|3069259_3069691_-\|tol-pal-system-associated-acyl-CoA-thioesterase	gnl\|CDD\|274304	TIGR02799, Acyl-CoA_thioesterase_YbgC, tol-pal system-associated acyl-CoA thioesterase. The tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).	3.91189e-64
NZ_CP018756.1\|WP_079222890.1\|3063248_3063950_-\|7-carboxy-7-deazaguanine-synthase-QueE	gnl\|CDD\|275145	TIGR04349, Radical_SAM_domain_protein, putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type. Members of this radical SAM domain protein family appear to be a form of the queuosine biosynthesis protein QueE. QueE is involved in making preQ0 (7-cyano-7-deazaquanine), a precursor of both the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. Members occur in preQ0 operons species that lack members of related protein family TIGR03365.	2.63319e-152
NZ_CP018756.1\|WP_079222891.1\|3064061_3064880_-\|tol-pal-system-protein-YbgF	gnl\|CDD\|224643	COG1729, COG1729, Uncharacterized protein conserved in bacteria [Function unknown].	4.40575e-51
NZ_CP018756.1\|WP_079222889.1\|3062504_3063170_-\|7-cyano-7-deazaguanine-synthase-QueC	gnl\|CDD\|284031	pfam06508, QueC, Queuosine biosynthesis protein QueC. This family of proteins participate in the biosynthesis of 7-carboxy-7-deazaguanine. They catalyze the conversion of 7-deaza-7-carboxyguanine to preQ0.	1.27471e-109
NZ_CP018756.1\|WP_079222883.1\|3057019_3057373_-\|DUF2750-domain-containing-protein	gnl\|CDD\|378546	pfam11042, DUF2750, Protein of unknown function (DUF2750). This family is conserved in Proteobacteria. The function is not known.	7.48168e-36
NZ_CP018756.1\|WP_079222885.1\|3058791_3059643_-\|alpha/beta-hydrolase	gnl\|CDD\|225375	COG2819, COG2819, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	7.96576e-41
NZ_CP018756.1\|WP_079225349.1\|3057369_3057798_-\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	1.14301e-10
NZ_CP018756.1\|WP_079222882.1\|3056168_3056591_+\|response-regulator	gnl\|CDD\|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	1.10839e-17
NZ_CP018756.1\|WP_079222893.1\|3065465_3066785_-\|Tol-Pal-system-beta-propeller-repeat-protein-TolB	gnl\|CDD\|179892	PRK04922, tolB, Tol-Pal system beta propeller repeat protein TolB.	0
NZ_CP018756.1\|WP_079222898.1\|3069680_3070721_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP018756.1\|WP_079222895.1\|3068016_3068445_-\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	4.82476e-48
NZ_CP018756.1\|WP_079222881.1\|3055630_3055936_-\|zf-TFIIB-domain-containing-protein	gnl\|CDD\|226331	COG3809, COG3809, Uncharacterized protein conserved in bacteria [Function unknown].	1.03324e-28
NZ_CP018756.1\|WP_079222892.1\|3064883_3065402_-\|peptidoglycan-associated-lipoprotein-Pal	gnl\|CDD\|274307	TIGR02802, Peptidoglycan-associated_lipoprotein, peptidoglycan-associated lipoprotein. Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.	3.50007e-59
NZ_CP018756.1\|WP_079222896.1\|3068469_3069249_-\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	4.39195e-106
NZ_CP018756.1\|WP_079222880.1\|3055043_3055556_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.10115e-10

>NZ_CP018756.1|WP_079222888.1|3061361_3061847_-|hypothetical-protein
MTFVELKRVGAMLVATVALGSTSVQAAEKSGATQGNVSTPASARADGVNPPERWYYLGSSASSKTYIDRQQKLRREGDTVTLSIRQVLDTVPDDLKVHPRTRYMDVRSRYDCKKHTVAHLSSLELSADNEYLGGEPRPLDPVPVHAGTLNAAVMDVACSAG
>NZ_CP018756.1|WP_079222887.1|3060928_3061246_+|hypothetical-protein
MLNALIIAALAAGPASSSPYADCVLANIQPGLSDRAVLLVQHACAAKYPDSYADAIELERRHSVQRQAQFDADHAEAVRSANEAATAAQAAADRSAAQTKGADPK
>NZ_CP018756.1|WP_079222886.1|3060481_3060850_+|hypothetical-protein
MNPRPPQASRSIHAVVNEVANDSNPARDLSTFWGCLKRIREGDAADGLCWPEPKLLPGRAQDLARVERAAVGMLTVAEMLHAAERCRVLATPDRHLDEGVVDGMLLACRGLAELVCRDIRPQ
>NZ_CP018756.1|WP_079222885.1|3058791_3059643_-|alpha/beta-hydrolase
MRLIVLSLLLSAVAATPLRAAEPAPAAQAAPATPLVIGETFTLESKALGETRRINVYRPQPWGLDPKTPLPVLYMPDGGIGEDFLHVAGLVQVLSGNDSMRPFLLVGIENTERRRDMTGPSSDPEDRKIAPRIGGSAAYRAFLRDELMPQVRQRYPTTDERALIGESLAGLFVVETLLQEPTLFNSYIALDPSLWWNKGALLASAPKQLPAVAKATPRVFLASSGQPELAQTTQQLSTLLHGASPSLQVDYQPFPQETHGTIYHPAALQALRTLFPAHPPAQP
>NZ_CP018756.1|WP_079222884.1|3057817_3058762_-|alpha/beta-hydrolase
MKHGRGWSALMCLALAGCAMSVTPPAAQDTAKQDPAAATATPGVVLPDTEALRVHDPVGRDYPIWIALPADYAAHPEKRYPVLYVTDALYSFPLVRSVRNLVGQQGVNIENFILVGLPPQEGLTSKQSRSRDYTPSNPVRRADGYYSDDVTYGGAEHYRDFLAAEVLPMIDARYRTDPARRAFAGHSYGALFGAYVLTTQPDLFSTYILSSPSLWFDELLLPRMQDNAVVPAQPTRVLLSVGSYETVKPGPRYSTGNDMLRQAGDFTAQLQRGGRKLQVDNVVIDGEDHLTVYPRVITRALLEVMPGEGPYTGG
>NZ_CP018756.1|WP_079225349.1|3057369_3057798_-|SMI1/KNR4-family-protein
MPPELVARVEALLAEHPSLRGQPATDTEIEAAQQIVGTVFAPQYVAFIKHFGGSFGGVDIHAFANGSLIGRSTVTELTLGFRERYGDDVSDHLRTALAVSDDGAGNPVLISARGEIMLYLHDEGEVEMLFPSLYDMMNAWLP
>NZ_CP018756.1|WP_079222883.1|3057019_3057373_-|DUF2750-domain-containing-protein
MSLHLTADMELLKERFIRRVREHGEVWGLRSEARGWAYCPSNDGDEDVLVFWSDRAYAARHAVDEWADYVPTVIALEAFMQRWLPGMQRDGALAGVNFNADLAGLELRPEVLLEALR
>NZ_CP018756.1|WP_079222882.1|3056168_3056591_+|response-regulator
MLLSKRHVEPRVLLIEDAEETRELSRMALESQACHVVGVSSAEAALGLLAAGERFDLLFTDVNLGLVSGIEAANHVRGLYPQLPILVTSGMDQHAVLPQLRDGIHFLPKPYNMSELLDAIRLCFRHADAGVLTSPDAQAA
>NZ_CP018756.1|WP_079222881.1|3055630_3055936_-|zf-TFIIB-domain-containing-protein
MQCPVCTTQTLQMAERHGIEIDYCPGCRGVWLDRGELDKIIERAGAAVPAPVQAAPQVAPPPVMHRDTRHLGQRQDEHRGQYGHGYKKKKKESFLSELFDF
>NZ_CP018756.1|WP_079222880.1|3055043_3055556_+|GNAT-family-N-acetyltransferase
MSLQIRRATLADAEALSAIAIATYTETWGDSYPPQELDVFLQDHYGIAPQREELSDPRSAVWLLLEDADVVGYLAAGANTLPHADAREGDIELKRLYILAAYQNGGHGARLMDAFIAWLDQPRHRTLWVGVWEENFAAQRFYARYGCEKAGEYDFIVGSTLDREFILRRP
>NZ_CP018756.1|WP_079222889.1|3062504_3063170_-|7-cyano-7-deazaguanine-synthase-QueC
MKKAVVLLSGGMDSAAVIAMAQEQGFAVHALSVRYGQRHTSELDAAVRVAKAQGVIAHKTVDVDLRSIGGSALTDDIDVPEAGGEGIPVTYVPARNTIMLSLALGWAEVLGANDIFCGVNAVDYSGYPDCRPEFIAAFQALANLATKSGVEGAGITVHAPLQFLSKAQIVTEGVRLGVDFGLTVSCYNADANGAACGHCDACRLRAQGFTDAGVADPTLYA
>NZ_CP018756.1|WP_079222890.1|3063248_3063950_-|7-carboxy-7-deazaguanine-synthase-QueE
MTAVSPSAAVATPSEIVQSPLPRLKITEIFTSLQGEADTAGWPTVFVRLTGCPLRCNYCDTAYAFHGGTWWDIDDIVAEVLAQGVRHVCVTGGEPLAQKRCLVLLQKLCDAGMDVSLETSGALDVSAVDPRVSRVVDIKTPGSAEAARNRLENLPLLTARDQIKFVICSREDYDWAKGMLAEHDLVKRCTVFFSPSKGEITARQLADWIVEDRLPVRFQMQLHKILWDDEPGR
>NZ_CP018756.1|WP_079222891.1|3064061_3064880_-|tol-pal-system-protein-YbgF
MRIGIKLMLVVAAALVAAAPAHAQRQSLADRVGSLEQQMYNNSANQDLLNQINQLRQQVTSLQSTLEQIQHENAQLKQSSQDQYLDLDGRLNRLEGGNAAPALPPVPATPSKAPAAPAQPTAAATSERPPSVHGDPGSLAATGDERTSYNVAFDALKAGKYDDSAQLFLSFLELYPNGVYTPNALYWLGESYYATRNFPMAETQFRELLSRYPTHDKAPGGLLKVGLSLYGEGKVDQAQQTLETVVAQYPGSDAARTAQDRLQSIRLGRQIR
>NZ_CP018756.1|WP_079222892.1|3064883_3065402_-|peptidoglycan-associated-lipoprotein-Pal
MNKSTRVLLVSLLSVAVLAGCSKKVKEEPAAPVDTGTSTTAPTGPSTSGLYGPGDLDTDACLRQRVVYFDLDKEDVKPEFQAIMACHAKYLRDRPSSRITLQGHTDERGSRAYNQALGERRGNGVNSALQANGGSASQLTVVSYGEERPVCTESNESCWSQNRRVEIVYTAQ
>NZ_CP018756.1|WP_079222893.1|3065465_3066785_-|Tol-Pal-system-beta-propeller-repeat-protein-TolB
MKKMPRWLAVFAALLLPFAAFAQQKGLDIDIIGGNASALPITVVPMPYQGSAGAPQTDVAGVVRADLERSGQFRTLPEAQIVEKPTRGGEIQFPTWRALKQNYIVVGRVMDAGAGAYRVEYELFDVPKGERLLGLAMTARGNAMRDVAHQMADAIYEKITGVRGAFWTRIAYVTASGKGDAMRYALMVADSDGYNPQTIVRSAEPLLSPSWSPDGGKLAYVSFERGNSAIYIQNISTGARELVTSFRGINSAPAFSPDGRKLALTLSRSGNPEIYVMDLGSKQLTQLTNHFAIDTEPTWAPDGSAVYFTSDRGGRPQVYKVGAGGGSAERVTFQGNYNAKPSVSYDGKKIAVAQGSGNSYKIAVMDSSLGSARWNTLSVGSLDESPSFAPNASMVLYAAREGGRGVLYAVSADGRVRQRLVLADGDVREPAWSPYRTQR
>NZ_CP018756.1|WP_079222894.1|3066965_3068027_-|cell-envelope-integrity-protein-TolA
MHADTLPPPHKQEPGWGLPLGLAVLVHLLVALVFIVAWLWSPERNTEAAAGDPSVEASLALSSAEAAAARQALRQSEKLEDLPQPVPEPVPVAVPEDTIPPPQPIEAPRPQDAPTPQQQQAQERVAQPDTKDQDAANALAISQEKAKQEQEAKRRQEQIDLTERKRQEEAEQKARLAKQQEEDAKKKIADQQKVAADKAEAERQKKIADIRAKREQAEKEAKLAEQKLRQVAAARNAAGAASSGSTSAAQPAAGGGGTSDDLSAKYAAAIQAKVLASWSRPDSVPLGQKCQITINQLPGGTVRSATVSGSCPYDEAGKRSIEAAVLNAQPLPYRGFESVFARTINFTFTAQDR
>NZ_CP018756.1|WP_079222895.1|3068016_3068445_-|protein-TolR
MSAAIGRRKRRKLKSEINVVPYIDVMLVLLIIFMVTAPLLTLSFDVDLPQSNAKALESKQDPVIVSVREDGQLSLKLPDAKEPVAVSAEELEGRLAGIAAQDKGVRVIVAADRAVAYEKVIAAMDVIKRAKVDKVGLATDAR
>NZ_CP018756.1|WP_079222896.1|3068469_3069249_-|protein-TolQ
MIATLLALQATVTEALPADVSNAATQTLAQATTGGGINYLELMAKASLPVKIIVLLLLVGSFVSWVIIFRKARVFKQATREADEFENRFWSGADLGKLYSSATDRSRNVGGLEAIFEAGFREYSRLRDKRRLDGRAQLEGAQRAMRTTYTREVDQLERNLELLANIGSTAPYVGLVGTVFGIMVTMHDMISSGAQAGIAAVAPGISEALFATAIGLFVAIPAVWAYNRFTTRVERMSVRFETFAEEFSSILQRQSAGDE
>NZ_CP018756.1|WP_079222897.1|3069259_3069691_-|tol-pal-system-associated-acyl-CoA-thioesterase
MSVEPRFSWPTRIYWEDTDAGGVVYHARYVAFMERARTEWMRALGYGQERMRSEHGMVFAVRSMQMDFIKPARLDDALQVSATLVQLKKASMVFDQRVERDGELLLSAQVRIAALDAASFRPRGMDEPVLAALQPYLHPESEL
>NZ_CP018756.1|WP_079222898.1|3069680_3070721_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MTDDRIIGAGATREDDAADASIRPKRLADYLGQAPVREQMEIYIQAAKARGDALDHVLIFGPPGLGKTTLSHVIANELGVALRVTSGPVIEKAGDLAALLTNLQPHDVLFIDEIHRLSPVVEEVLYPAMEDFQIDIMIGEGPAARSIKIDLPPFTLIGATTRAGLLTAPLRDRFGIVQRLEFYSVEELTRIVRRSAAILAIDCTADGAGEIARRARGTPRIANRLLRRVRDYAQVKAGGHIDEAVAQAAMKMLKVDPEGFDELDRRLLKTMVDYFDGGPVGIESLAAALSEERGTLEDVVEPYLIQQGFLVRTARGRMATHKAYRHMGLKPKNPPQDLFAEVPDVG

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Crispr_ID: NZ_CP018756_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_22

3177148-3177288

Orphan

Consensus_repeat	Method
TCGATATCTGACAGATGTGCCGACCAACGGTCGGCACCCACCAACAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_22

>merge|NZ_CP018756|22|3177148-3177288|CRISPRCasFinder
TCGATATCTGACAGATGTGCCGACCAACGGTCGGCACCCACCAACAGCCGCGCATGCCCAGTAGAGCCACGCCATGCGTGGATGAATTTCATTCGATATCTGACAGATGTGCCGACCAACGGTCGGCACCCACCAACAGCC

>NZ_CP018756|22|21|3177148-3177288|CRISPRCasFinder
TCGATATCTGACAGATGTGCCGACCAACGGTCGGCACCCACCAACAGCC	GCGCATGCCCAGTAGAGCCACGCCATGCGTGGATGAATTTCAT
TCGATATCTGACAGATGTGCCGACCAACGGTCGGCACCCACCAACAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079222981.1\|3178688_3179648_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273465
NZ_CP018756.1\|WP_079222982.1\|3179878_3180475_+\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|234759
NZ_CP018756.1\|WP_079222993.1\|3188431_3191107_-\|DUF2339-domain-containing-protein	unknown	unknown	gnl\|CDD\|378390
NZ_CP018756.1\|WP_079222980.1\|3177495_3178479_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|183677
NZ_CP018756.1\|WP_079222976.1\|3170067_3171579_-\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NZ_CP018756.1\|WP_079222974.1\|3168063_3169050_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222989.1\|3185274_3186450_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP018756.1\|WP_079222972.1\|3165119_3166541_+\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349879
NZ_CP018756.1\|WP_079222977.1\|3171769_3172303_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP018756.1\|WP_079222991.1\|3187058_3188435_-\|DUF3999-domain-containing-protein	unknown	unknown	gnl\|CDD\|372507
NZ_CP018756.1\|WP_079222978.1\|3172295_3175421_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079222973.1\|3166601_3168053_-\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NZ_CP018756.1\|WP_079222970.1\|3163745_3164468_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP018756.1\|WP_079222983.1\|3180523_3181561_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079222987.1\|3184609_3185278_-\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|319798
NZ_CP018756.1\|WP_079222975.1\|3169227_3170067_-\|rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|236779
NZ_CP018756.1\|WP_079222971.1\|3164521_3164926_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|234795
NZ_CP018756.1\|WP_079222985.1\|3182928_3184395_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
NZ_CP018756.1\|WP_079222984.1\|3181697_3182702_-\|fructose-bisphosphate-aldolase-class-I	unknown	unknown	gnl\|CDD\|380231
NZ_CP018756.1\|WP_079222979.1\|3175417_3176524_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079222981.1\|3178688_3179648_+\|cysteine-synthase-A	gnl\|CDD\|273465	TIGR01139, Cysteine_synthase, cysteine synthase A. This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family].	1.73376e-164
NZ_CP018756.1\|WP_079222982.1\|3179878_3180475_+\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|234759	PRK00431, PRK00431, ADP-ribose-binding protein.	2.09466e-89
NZ_CP018756.1\|WP_079222993.1\|3188431_3191107_-\|DUF2339-domain-containing-protein	gnl\|CDD\|378390	pfam10101, DUF2339, Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.	1.19129e-68
NZ_CP018756.1\|WP_079222980.1\|3177495_3178479_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|183677	PRK12680, PRK12680, LysR family transcriptional regulator.	0
NZ_CP018756.1\|WP_079222976.1\|3170067_3171579_-\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_CP018756.1\|WP_079222977.1\|3171769_3172303_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	6.09419e-25
NZ_CP018756.1\|WP_079222989.1\|3185274_3186450_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP018756.1\|WP_079222972.1\|3165119_3166541_+\|M28-family-peptidase	gnl\|CDD\|349879	cd03883, M28_Pgcp_like, M28 Zn-Peptidase Plasma glutamate carboxypeptidase. Peptidase M28 family; Plasma glutamate carboxypeptidase (PGCP; blood plasma glutamate carboxypeptidase; EC 3.4.17.21) subfamily. PGCP is a 56kDa glutamate carboxypeptidase that is mainly produced in mammalian placenta and kidney, the majority of which is thought to be secreted into the bloodstream. Similar proteins are also found in other species, including bacteria. These proteins contain protease-associated (PA) domain inserts between the first and second strands of the central beta sheet in the protease-like domain. The PA domains may participate in substrate binding and/or promoting conformational changes, which influence the stability and accessibility of the site to substrate. The exact physiological substrates of PGCP are unknown, although this enzyme may play an important role in the hydrolysis of circulating peptides. Its closest homolog encodes an important brain glutamate carboxypeptidase II (NAALADase) identical to the prostate-specific membrane antigen (PSMA), which serves as a marker for prostatic cancer metastasis. Hypermethylation of PGCP gene has been associated with human bronchial epithelial (HBE) cell immortalization and lung cancer. PGCP also provides an attractive target for serological analysis in hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) patients.	0
NZ_CP018756.1\|WP_079222991.1\|3187058_3188435_-\|DUF3999-domain-containing-protein	gnl\|CDD\|372507	pfam13163, DUF3999, Protein of unknown function (DUF3999). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 440 and 470 amino acids in length. There is a single completely conserved residue D that may be functionally important.	2.21486e-92
NZ_CP018756.1\|WP_079222978.1\|3172295_3175421_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079222973.1\|3166601_3168053_-\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_CP018756.1\|WP_079222970.1\|3163745_3164468_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	5.35482e-76
NZ_CP018756.1\|WP_079222987.1\|3184609_3185278_-\|HAD-hydrolase-like-protein	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.17583e-88
NZ_CP018756.1\|WP_079222975.1\|3169227_3170067_-\|rRNA-methyltransferase	gnl\|CDD\|236779	PRK10864, PRK10864, putative methyltransferase; Provisional.	7.44093e-71
NZ_CP018756.1\|WP_079222971.1\|3164521_3164926_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|234795	PRK00567, mscL, large-conductance mechanosensitive channel protein MscL.	8.63645e-67
NZ_CP018756.1\|WP_079222985.1\|3182928_3184395_-\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
NZ_CP018756.1\|WP_079222984.1\|3181697_3182702_-\|fructose-bisphosphate-aldolase-class-I	gnl\|CDD\|380231	NF033379, FrucBisAld_I, fructose-bisphosphate aldolase class I. This family consists of fructose-bisphosphate aldolase class I. All members of the seed alignment are from prokaryotes, although class I is the common form in plants and animals. The common form in prokaryotes is class II.	0
NZ_CP018756.1\|WP_079222979.1\|3175417_3176524_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	2.84868e-70

>NZ_CP018756.1|WP_079222979.1|3175417_3176524_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MLARITSTLALGLSLAVLAGCAGKQEAAARRQGEAVPVTAQVVQPSQWNDTLQALGTAKARESISVTAKVSEIVDRVHFESGQQVAAGAPIVTLRGQAQEAALVQAQATFHEADQLYKRQRELATQRLVSSATLDTQKSIRDAAEARVAQMQADIGDRRVRAPFAGVLGIRQVSPGTLLTPTTVIATLDDIERMHVDFQVPEVEMAALSNGDKVSATSVAWPGRTFEGEVTTIDARVDPATRAVTVRADFANADHALRPGMLLDVRLFRPERPALVVPEIAVVQVGRDTFMYRIKADDTVERIDVTTGARRAGVVEIRQGLQGGERIVVDGTGKLRAGLKVAATDAAPASGTAPAKTPAPAPAEGNGG
>NZ_CP018756.1|WP_079222978.1|3172295_3175421_-|efflux-RND-transporter-permease-subunit
MKLSDISIQRPVFAVVMSLLLVVLGIMSFTRLTLRELPAIDPPIVSVSVDYTGASAAVIESRVTQVLEDALAGIEGIDTINARSSNGRSQVSIEFTSNRDIEAAANDVRDAVSRVADRMPEEARPPEIAKVESDADPIIWFNMSSTTMDTLELSDYADRYVVDRFSSLDGVAQVRIGGRQRYAMRIWLDRDQLAARGLTTGDVETALRNENVELPAGRIESTDRDFTLRVERNYVKPEDFATIPLGKGSDGYVVRMGDVAKIELASAERRAYFRSNGEPGVGLGIVKTSTANSLDVARAARAEAEKVAATLPEGTQIVVTFDNTTFIEAAVDRVYATLIEAMLLVLAVIWLFLGSFRAALIPAVTVPVCLVAAFIALYAFGFSINLLTLLALVLCIGLVVDDAIVVVENVQRRIDLGEPPLVASKRGTTQVAFAVIATTAVLVAVFLPVGFLEGNTGRLFRELAVALAAAVALSAFVALTLTPMMASKLLKPHSGHAPRGLYGVINRNLERLASGYGRVLDHHVDRLWIYLVVMALALAASWGLLKILPSELAPAEDRGSFQIMIDGPEGAGYDYTVQQVQQVEALLAPHVGADKTIARANPRVPGGFGASEEMHTGRVSVFLQPWRQRTENTVDVANDLQKELDTLRGVRVRTQVGGGLVRSGGQPFQIVLGGPEYAEIAQWRDRILLRMADNPGLVGPDSDYKETRPQMRVNIDRQRAADLGVPVTAIGSALETMMGSRRVTTFVDNGEEYDVLVQAGRDGRASPADLAAIRVRANSGELVPLSNLVTLSEVAEAGTLNRFNRLRSITISAGLAPGYPLGEAIAWAQQVTREELPQYAQVNWKGESREYQSAGGAVLLTFAMALLVVYLVLAAQFESFIHPLTIMLTVPLGVLGALVGLWVSGGTVNLFSQIGIVMLVGLAAKNGILIVEFANQLRDDGRTVRAAIIESAVVRLRPILMTSIATVVGAIPLVVAGGPGSASRGTIGIVIIFGVTLSTFLSLFVVPAFYARLAPYTRSPEAVKRELEKQEAESPSVGGHA
>NZ_CP018756.1|WP_079222977.1|3171769_3172303_-|GNAT-family-N-acetyltransferase
MPDPRLQGEGFCLRPWRSDDLASLLRHADDPEVSRGLRDRFPSPYTRADGEAFLAGRVLGPGTLNLAIEIDGQACGSVGAQPGTAERGHTAELGYWLGRALWGQGVMTRVVGLFAPWVMDELRLFRLQAEVLDFNEGSARVLLANGFAEEGTARCAVYKRGVLHDLRRFARVRTQLP
>NZ_CP018756.1|WP_079222976.1|3170067_3171579_-|alanine:cation-symporter-family-protein
MEATVHFINSIIWSKALIVVCLGAGLYFSLRTRFMQIRGFFEMCRLTVQGEKSEAGVSSFQALAMSMAGRMGIGNIAGVATAIAFGGPGAIFWMWVMGFLGASTSYVECTLAQIYKTKDAEGRYRGGPAYYIEKAMGLKWYALAFAIATIIAAGFLMPGVQANAIADSVINACRGTAVCGPLDGQMLGMSSVEALKLGIGIAVALLLGVVIFGGVKRIANFAEVVVPFMAAAFILMAIVIMVINYDRVPEMFGIIFDSAFGTHAAFGAMMGLAVEWGIKRGIYANEAGQGSGPHAAAASEVSHPAKQGYVQAFAIYFDTMMVCTATAFLILASGTYNVYSPAGANAPPIFQGLAGIPEGAGYAQAGVEAVLPGWGAAFVSIAIFFFAFTTIMAYYYMAETNLTYVNHNKKRPLTVLVLRLGIIAMVVFGAFHNATLAWALGDIGVGLMAWLNIIAILIVQKPAMLALRDYERQKKLGLDPTFDPDALGIKNADFWRQRKQENV
>NZ_CP018756.1|WP_079222975.1|3169227_3170067_-|rRNA-methyltransferase
MNNPWNNRRPSARPPRATPLPRPEVPATGGGGGGRGGNDELRLFGLNAVLAAFEARPQALRKLYLLEARIPRLQPLLKWCVANRVGYRVVEDGDLNKLAGTTHHEGVVADVVRAPVLPLAQWLQQVGDGPALALWLDGVGNPHNLGAILRSAAHFGAKALLLPAGSTLALSGAAARVAEGGAEALPLVQLPGDADAMAALRAAGFGLAATLVEGGQDVFRAELPARLVYVMGAEGEGMDRALASQCDQQVSIPGSGAVESLNVASATAVLLAQWSSRHG
>NZ_CP018756.1|WP_079222974.1|3168063_3169050_-|hypothetical-protein
MSHLQRTLSVSLLLASALASASACANERSLENVNFMGPLITPNPAGLPQGRWFLEPYLVRVDSNAHYDADGERQRSAQDSGAWAVVMPVMYGFSDRLMGQVNLSASRAESGTGHSGGFRAGDTTARLQYLLQAPSADGTRPAVSLAVSQRFSTGSHDRITGNPLDAQGDGVQRTTVALGVQQVVWMPNGRPLRWRGQLMAGPAPARTALSGASIYGTEAGFQGHIARGSVLGLSVAGEYSFNDRWVGVMELAASRETGQRLIGFMPTADGGGRRIDEQRPASRSLSVAPAVEYHFSPSLGLIAGVEITLAGRNTGRVISPQVALGVFF
>NZ_CP018756.1|WP_079222973.1|3166601_3168053_-|alanine:cation-symporter-family-protein
MSIESIVNVLLGIIWSPWLVVLCLLAGLYFSVRTRFIQLRALPDMLRLMFRHERSEAGVSPFQALSLSLSSRVGVGNIAGVAMAIAFGGPGAIFWMWIVAFLGASSAFIESTLAQIYKERDASGQYRGGPAYYIEKGLGQRWYAVLFALVTVLAGAMLAGTQSNAITSAVNEAWGIPVAGTTAVLLAVLAAVLYGGVRRIARVAEWVVPIMAVAYLLVAAVVMVINVDRVPEVLALVLRSAFGVDAAFGAMIGTAIQWGVRRGVLSNEAGMGSGAHPAAAAEVSHPVKQGLVQSFSVYIDTMVVCSATAFLILSTGLYNVYDPAVNGVPDEARLLLANLPGVEAGPRFVQHAVESALPGFGRSFVALAILPFAFTTILALYYMAETNVSYLCRDRPGRATVTGFQLLFLGATGYSAVNTATVAWALGDIGVGMMSWLNIIAILLLQKPALAALRDYEQQKRQQRDPLFRPQAIGMRNTRVWQG
>NZ_CP018756.1|WP_079222972.1|3165119_3166541_+|M28-family-peptidase
MRRRVLAIASSLALLAAPAFAAPRTTTLPPASLATAAQLRDQALADDTGWKVVESLTTEIGPRIAGSEADARAVAWAEAKFKALGFDKVWKEPVTFPKWERRSEHAAVTGRNPQPLQITALGGSPGGSVEAEVVRFADLAALQAAPEGSLKGKIAFVDYQMLPFRDGRDYGRGGAIRSKGPSEAIRKGAVGFLMRSAGTDSHRVPHTGITRFDDGLTPVPSAALSVPDADQLARLVARGTTTVKVALDCGWDGTATSYNVIGEITGRRLPKEVVVIGGHLDSWDLGTGAVDDGAGVGITMAAGHLIGQLKQAPKRTIRVIAFANEEQGLYGGKAYAEAHAKDVTLHQLAAESDFGAGRIYAFNTGSPNPEGSRDATRQIAEVMKPLGIEYMADKGGPGPDVGPLAAKGGAWAWLAQDGSDYFHLHHTADDTLDKIDPKALAQNVAAYTVFAYLAADADGSFGSEAKATTPPNE
>NZ_CP018756.1|WP_079222971.1|3164521_3164926_+|large-conductance-mechanosensitive-channel-protein-MscL
MGMLTEFKEFAMRGNVIDLAVGVVIGAAFGKIVTALVEKIIMPPLGMLIGKVDFSDLAWTLSAASIGPDGKEIPAVVIGYGDFLNTLVQFIIVAFAIFMVIKVINRLSRKKDAAPAAPKEEVVLLREIRDSLKK
>NZ_CP018756.1|WP_079222970.1|3163745_3164468_+|fumarylacetoacetate-hydrolase-family-protein
MSTAVVSDVIPAPAVPRVPVVGGGTFPVHRIYCVGRNFADHAREMGAAVPAADDRGRPMFFCKPADAIVVGHDDVIPYPPATSNLHHEVELVVAIGVDAPAGELAVADADALIYGYAVGLDLTRRDLQAAAKEKGHPWDSAKGFDASAPISEIVHAGEVGDLAALNLSLEVNGEVRQQSLLDQMIWNVPEILHELSKLWQLRAGDLVFMGTPSGVAALKPGDRFSARLENVAERHGVIAG
>NZ_CP018756.1|WP_079222980.1|3177495_3178479_-|LysR-family-transcriptional-regulator
MTLTQLRYLVAIADAEMNITLAATRVHATQPGLSKQLKQLEDELGFLLFVRKGRSLESVTPAGTEVISRARAVLAEANNIRTYAANQRRESQGQLILTTTHTQARFVLPPAVAAIKQAYPQVSVHLQQAGEADALDRLNQGDADIAIISTAGGEPTDGIAVPLFRWRRLVVVPKGHPLDRAGRAPDLAALARQPLISYESSTRPSSSLQRAFAANGLVPDLALTALDADLIKTYVRTGLGVGLLAEMAVSSNDEDLRSWPAPEPITECIAWAVLPRDRVLRDYALELVHVLAPQIDPRDLRRVLDGNQAAAWPVPPTWESLTQTITV
>NZ_CP018756.1|WP_079222981.1|3178688_3179648_+|cysteine-synthase-A
MALYDSILDTVGNTPIVKLQRLAPQGVTLYAKVESFNPGGSVKDRLALAIILDAEARGLLKPGDTIVEATSGNTGVALAMVAAARGYKFVATMVETFSVERRKLMRAYGAKVILTPAAERGSGMVRKAAELAEQHGWFLASQFANPANPAYHRNTTAAEIVRDFAGKRLDYFVSGWGTGGTLTGVGEVLKVARPQTRIVATEPAGAALLKGDDWKPHKIQGWTPDFVPDVLNRDVVDELLTVEDDRAIATARRLAAEEGIFVGISAGATVASALDVAARAEPGSVILAMLPDTGERYFSTPLFAEVNEGSDDDWLAGLP
>NZ_CP018756.1|WP_079222982.1|3179878_3180475_+|O-acetyl-ADP-ribose-deacetylase
MKIEVWQGDITTLAVDAIVNAANETLLGGGGVDGAIHRAAGPELLAECERLPELRPGVRCPTGEVRATDAYALPARHVLHTVGPVWHDGQRDEPALLANCYWKSLQLAESLGVHSIAFPAISCGVYGYPLYQAAQVAVTETLAWQRSHAQPMRIVLVAFNTATAKAYQQALAAAGQAVEAERILPLPPVGDAGYAAAH
>NZ_CP018756.1|WP_079222983.1|3180523_3181561_-|ABC-transporter-substrate-binding-protein
MRTTAIALAIATVLSVAGCDRFGAPEPSGRVPVLQFDKPVSGEITSRNGTNFNDGSHHQLYQITLQDKQRVGITLTGALSGAMTVFHDGKVVARSRATDEGSSVAVAFRADGGGSYQVAVNASGPDTYGPFRLRAEQLKPYDGKPIINTGHIADLLLETSQTYTLQVDSAGLYTIDLRSDVFDTLLALEGEGQDAENDDGGEGSDSRISLLLQPGRYTLSVSALDDEDSGAFTLDVQRSKVPATIVDQDGTPLPASGSVFTVLDADGRRRFLLSLDAPARVQVDALSSQVDTVLRVVGGDIDIEDDDGGSGTDARLQETLPAGHYTVDVSSIGGDSGLVELRIQR
>NZ_CP018756.1|WP_079222984.1|3181697_3182702_-|fructose-bisphosphate-aldolase-class-I
MSIEQLAETAQAMVAPGKGIIAIDESTATIAKRFAGVGIENTEENRRAYRELLLTTPKLNEHISGAILYDETIRQSTKDGVPFAKYMADHGMIPGIKVDKGAHPLAGCPGELVTEGLDGLRERLQEYYKLGARFAKWRAVINIGENTPSGTCIESNAHALARYAALCQECGLVPMVEPEVIMDGDHDIETCYEVTEATLRSLFDALYQQNVLLEGTILKASMVISGKGCDEQADAEEVAESTVMCLKSTVPAILPGVVFLSGGQSDEQSTEHLNAMNQLGNLPWPLSFSYGRAMQQAALKLWAKDMKGNYAAAQKTVYERAKDNGLAALGKWNG
>NZ_CP018756.1|WP_079222985.1|3182928_3184395_-|pyruvate-kinase
MFERQRRTKILATLGPATDPPGVLEDLFRAGVNVVRLNFSHGDPSGQAKRAADVRAASARVGVEVGILADLPGPKIRIERFAEGKVYLKAGDRFDLIASDNAGPGDASQVGVSYLGLPQDVGPGDVLLLDDGLMQLQVVEVQGDRIINTVLNDGALSDRKGLNKQGGGLSLGALTERDKELIGIVAKIGVDFIAVSFCRNAQDMNDARQIAESHGCYAALVSKIERTEAIENLEEIVEASDVVMVARGDLGVEIGDAELPGLQKKIIKASLAQNKVVITATQMLQSMVESPIPTRAEVLDVANSVIDGTDAVMLSAETAAGAYPVKAVEAMARICLGAERQFQTETDFNASPRNLERADQAIAMATMFLSQHVGVRAIVAMTESGGTARYLSRFRAKAPVFAVTRHDGARRQMALMRDVYPINFDSRGLTPREAARGSIRLLVESDLLQAGDRVVFTSGEHMETLGATNTLRLLEVGEDGRASGLGDL
>NZ_CP018756.1|WP_079222987.1|3184609_3185278_-|HAD-hydrolase-like-protein
MSAGLRADGEERATLFFDMDGTLIDSEVGITTCIAYALQKMGHPVPPQETLQGWIGPSLRTTFTPLFGDDVRVEEAVAYYRERFDVEGWREHTLYPDIEATVRALHDRGHRLAVVTAKNEPHARRIVEHLPFGGLFDDVIGSTPDGSRSSKAQLVGEALQRLRLQPAQCWMIGDRRMDIEGARHHGLRNVGVLWGFGGEAGLIEAGADHLAREPAQLLALLA
>NZ_CP018756.1|WP_079222989.1|3185274_3186450_-|phosphoglycerate-kinase
MSIVRMTDLDLSGKRVLIRQDLNVPIENGRITSEQRITASLPTLKRALEQGAAVMVTSHLGRPKEGVWTEADSLAPVAARLSELLGREVPLVRDWVDGVDVQPGQLVLLENCRMNVGEGKDDEALSKQYAALCDVFVMDAFGTAHRAQASTHGVIRFAPVAAGGPLLMAELDALAKALDAPAKPLLAIVAGSKVSTKLELLANLVGKVDQLIVGGGIANTFIAAAGYKVGKSLYEPDLLDTAKKIVADAQARGAAIPLPVDVVTAKQFLPDAAAEVKAVDAVADDDLILDIGPQTAAQYAQLIEKAGTVVWNGPVGVFEFEAFSKGTEALARAIASSRAFSIAGGGDTLAAVDKFDIAGDVSYISTGGGAFLEFLEGKTLPAVAALAARGA
>NZ_CP018756.1|WP_079222991.1|3187058_3188435_-|DUF3999-domain-containing-protein
MKTWRSALLPILLAVAGTASAQANDYRRHYAEQWPLSLSSAQSGAYRVVLEPAIYRRAGRADLGDLQVFNAAGQALPSALLAPDQPLAQPPVQRELPWFALPPLAEAQRNDLQLLTERDTDGRVRRVEARVGSGAVANGQGGWLIDGSVLGQQPVAALVLDWADSGQPLQAQVQVDASDDLQHWRAVSRDVPLVDLQRAGKRLLQRRLQVDGNARYLRVLPQGEARLPTLRSVLAELPPAPATVPWEWLSLQPTAAGKGEYTFELDGRFPVSKADVASTDNSLVQWTLYSRDDANAEWQRRSAPWIAYQVQQGAPGQRQQSAAQSLAGPWRDRYWKLVASPVETATAPTLRLGYQPEVMVFLSQGAAPYALAVGSATARRAEAPIAVLIEELRQRNDPAWQPTLARLEGAPETLAGAAALEPQRDWKAWLLWALLGLGVLVVGGLAVSLLRQKPAPSA
>NZ_CP018756.1|WP_079222993.1|3188431_3191107_-|DUF2339-domain-containing-protein
MEALIVLVVLALLAIPLLLVVALVMIAGLRRRVAALESAVAEGIAAAAPPREPEAAVAPPRPAAPREPPLLRPAAAAPPPVVSQVPPVAPRPAPEPPAPPVPPVPPPVSARPPLPPQPKQPAQPNIVERAVGAAKRWFTEGNVPVKIGMLVLLAGVAALLKYVSDQGWLVLPIELRLAAITVGALCLLGFGWHQRERRRLFALALQGGAIGVLLLTIFAAFKRFELINPGFAFASSILLVAGLCVLAVVQNSRTLAVLGILAGFMAPLWLSTGSGNHVGLFSYYAVLNAGIFAIAWFRPWRALNLLGFAFTFGIGTFWGVLQYRADKFASTEPFLLLFFAFYLLIPLLYARRQPAERRDLVDGSLVFGTPLIAFSLQAGMLHEQPMTLALCALGLAAVYALLARALIHRASYSVLAQSHAVLAVGFATLAVPLALSARATGAVFALEGAGLAWLGLRQKRWLPQVAAALLQLGAAFAFVVGADHWHGDTRFLLNATAVGALLLAVAGFASAWSYQRRARHDVALVYYLWGLLWWLGGFVHEIVRFIEHAAKADALLVLAAVTAWLAAEVHRRQPARALGMTALLMLATGFPLALLQGDAHQQPFAGYGGLAWAVFAVLGVRTLLCLRQSGDGVGRIAQFLWWLLWPSLLSLLALWGDDAAQLAQGWTALLVTLPWLLLAAVSLWRWTWLRWPLGDAFDAARTTLQTVVFGVLACAWWIGISLAGDADPLPWLPVLNPAELAQWLSLLLAARWLFGSQAPASLQRLRVPVLALAGFIALTSTVLHGVHHWGGAPWSPSMARGSLAQTSLTVLWSVLGVIAWVWGSRRGQRVLWMVGAVLMAVVLAKLVLIDRQHLGNLLGIASFIAYGLLCTVVGYLAPAPPGTAPTVENTQ

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Crispr_ID: NZ_CP018756_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_23

3252379-3252500

Orphan

Consensus_repeat	Method
GAGCCAGTAGATCCACGCCATGCGTGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_23

>merge|NZ_CP018756|23|3252379-3252500|CRISPRCasFinder
CAACAAGTAGATCCACGCCATCCTGAGCCAGTAGATCCACGCCATGCGTGGATAAGACCCGGCACAGTGCGGACCAACGGTCCGCACCCACCAGAGCCAGTAGATCCACGCCATGCGTGGAT

>NZ_CP018756|23|22|3252379-3252500|CRISPRCasFinder
CAACAAGTAGATCCACGCCATCCTGAGCC	AGTAGATCCACGCCATGCGTGGATAAGACCCGGCACAGTGCGGACCAACGGTCCGCACCCACCA
GAGCCAGTAGATCCACGCCATGCGTGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079223103.1\|3254585_3255428_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181349
NZ_CP018756.1\|WP_079223107.1\|3259111_3259774_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|237032
NZ_CP018756.1\|WP_079223085.1\|3244049_3244529_+\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|225498
NZ_CP018756.1\|WP_079223108.1\|3259859_3261854_+\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP018756.1\|WP_079223101.1\|3252507_3253458_-\|YiiG-family-protein	unknown	unknown	gnl\|CDD\|372366
NZ_CP018756.1\|WP_079223099.1\|3250225_3251452_-\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|179868
NZ_CP018756.1\|WP_079223092.1\|3246700_3246925_-\|rubredoxin	unknown	unknown	gnl\|CDD\|224687
NZ_CP018756.1\|WP_079223096.1\|3247602_3248892_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NZ_CP018756.1\|WP_152027112.1\|3253491_3254526_-\|YiiG-family-protein	unknown	unknown	gnl\|CDD\|372366
NZ_CP018756.1\|WP_079223098.1\|3249565_3250168_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319790
NZ_CP018756.1\|WP_079223105.1\|3256597_3257101_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223094.1\|3246959_3247586_+\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NZ_CP018756.1\|WP_079223091.1\|3245814_3246660_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225464
NZ_CP018756.1\|WP_152027114.1\|3257999_3258485_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223097.1\|3248993_3249443_-\|azurin	unknown	unknown	gnl\|CDD\|259989
NZ_CP018756.1\|WP_079223104.1\|3255512_3256193_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_152027113.1\|3257226_3257697_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223087.1\|3244551_3245199_+\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_CP018756.1\|WP_079223089.1\|3245218_3245662_+\|DUF192-domain-containing-protein	unknown	unknown	gnl\|CDD\|376876
NZ_CP018756.1\|WP_079223106.1\|3258608_3259115_-\|DUF2867-domain-containing-protein	unknown	unknown	gnl\|CDD\|378548

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079223103.1\|3254585_3255428_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|181349	PRK08278, PRK08278, SDR family oxidoreductase.	9.03322e-170
NZ_CP018756.1\|WP_079223085.1\|3244049_3244529_+\|EVE-domain-containing-protein	gnl\|CDD\|225498	COG2947, COG2947, Uncharacterized conserved protein [Function unknown].	7.35365e-79
NZ_CP018756.1\|WP_079223101.1\|3252507_3253458_-\|YiiG-family-protein	gnl\|CDD\|372366	pfam12889, DUF3829, Protein of unknown function (DUF3829). This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL_GvpF family of proteins, pfam06386.	1.3648e-46
NZ_CP018756.1\|WP_079223099.1\|3250225_3251452_-\|acetylornithine-transaminase	gnl\|CDD\|179868	PRK04612, argD, acetylornithine transaminase.	0
NZ_CP018756.1\|WP_079223092.1\|3246700_3246925_-\|rubredoxin	gnl\|CDD\|224687	COG1773, COG1773, Rubredoxin [Energy production and conversion].	1.50769e-21
NZ_CP018756.1\|WP_079223096.1\|3247602_3248892_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_CP018756.1\|WP_152027112.1\|3253491_3254526_-\|YiiG-family-protein	gnl\|CDD\|372366	pfam12889, DUF3829, Protein of unknown function (DUF3829). This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL_GvpF family of proteins, pfam06386.	2.08029e-57
NZ_CP018756.1\|WP_079223098.1\|3249565_3250168_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.56808e-32
NZ_CP018756.1\|WP_079223094.1\|3246959_3247586_+\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	8.86514e-74
NZ_CP018756.1\|WP_079223091.1\|3245814_3246660_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|225464	COG2912, COG2912, Uncharacterized conserved protein [Function unknown].	3.60245e-75
NZ_CP018756.1\|WP_079223097.1\|3248993_3249443_-\|azurin	gnl\|CDD\|259989	cd13922, Azurin, Azurin is a redox partner for enzymes such as nitrite reductase or arsenite oxidase. Azurin is a bacterial blue copper-binding protein. It serves as a redox partner to enzymes such as nitrite reductase or arsenite oxidase. The copper of Azurin is tetrahedrally coordinated by a cysteine, 2 histidines, and a methionine residue. The electron transfer reactions are carried out with the Cu center transitioning between the oxidized Cu(II) form and the reduced Cu(I) form. Azurin can function as a tumor suppressor; it forms a complex with p53 that triggers apoptosis in various human cancer cells.	6.72259e-66
NZ_CP018756.1\|WP_079223107.1\|3259111_3259774_-\|serine/threonine-protein-kinase	gnl\|CDD\|237032	PRK12274, PRK12274, serine/threonine protein kinase; Provisional.	4.99164e-134
NZ_CP018756.1\|WP_079223108.1\|3259859_3261854_+\|VTT-domain-containing-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	3.23267e-39
NZ_CP018756.1\|WP_079223087.1\|3244551_3245199_+\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	4.20346e-126
NZ_CP018756.1\|WP_079223089.1\|3245218_3245662_+\|DUF192-domain-containing-protein	gnl\|CDD\|376876	pfam02643, DUF192, Uncharacterized ACR, COG1430. Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for Structure 3pjy shows that there is much similarity with the other solved structure, Structure 3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. Structure 3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	7.78852e-45
NZ_CP018756.1\|WP_079223106.1\|3258608_3259115_-\|DUF2867-domain-containing-protein	gnl\|CDD\|378548	pfam11066, DUF2867, Protein of unknown function (DUF2867). This bacterial family of proteins have no known function.	2.00961e-34

>NZ_CP018756.1|WP_079223099.1|3250225_3251452_-|acetylornithine-transaminase
MTAATDPLISLSHYYLPVYKPRQVVLERGQGARVWDSQGREFIDLAAGIAVCGLGHNDPDLVAALVEQAGKLWHTSNVFYSAPPLHLAEELVQASRFAERVFLCNSGAEANEVAIKMVRKWASSKGRPADKRVIITFRGSFHGRTMGAVTATAQPKYQEGYEPLPGGFRYIDFNDEVQLETAMAAGDVAAVMLEPVQGEGGVMPAKSGFLKRVRELCDQHDALLVLDEIQAGMGRTGTLFAHWQDDVVPDMVTLAKALGGGFPIGAMLAGPKVAETMQFGAHGTTFGGNPLAAAVARVALRKLASPEIAANVSRQSKALRDGFARISEEFGVFSGVRGRGLMLGAVLSPAFAGQAGAILDHAADQGLLTLQAGPDVLRFVPSLNITDEEVAEGLKRLHAAIAAFVAAR
>NZ_CP018756.1|WP_079223098.1|3249565_3250168_+|HAD-IA-family-hydrolase
MRIDLLLLDVDGVLVQYQRTQRVLHLAQALDVPAASVQAALYESGLETAHDGGALDATTYLARLGQQLGRTVDARTWIAARQAASHPQDAVLQRLEHLQVPLAVLTNNGALMVQALPSLLPALFPALNDRVFCSADFGLRKPQPAVFLRVLEVLQVAPARTLFVDDLFANVRGARAAGLHAETVRDGRGLGKVLRRYAVR
>NZ_CP018756.1|WP_079223097.1|3248993_3249443_-|azurin
MKAWMVAVGLGAVMLAPSAMARVCAVSIDSTDQMSFSTRQIKVAADCSEVDLTLRHTGKLAATAMGHNWVLTRTADYQPVAMAGMRMTLADSYLPKADKRVLAHTKVIGGGETTRVRFSTKGLQKGGDYTFFCSFPGHFAMMKGSFVFG
>NZ_CP018756.1|WP_079223096.1|3247602_3248892_+|glutamate-1-semialdehyde-2,1-aminomutase
MNHDQSHALFSRAQQLLPGGVNSPVRAFKSVGGEPFFVERADGAYLHDVDGNRYIDYVGSWGPMIVGHNHPAVRQAVKKAIDNGLSFGAPCAAEVTMAETITRLVPSCEMVRMVNSGTEATLSAIRLARGATGRNRIVKFEGCYHGHGDSFLVKAGSGMLTLGVPTSPGVPAGLSELTLTLPYNDFDAATALFEAQGSDIAGLIIEPVVGNANCIPPREGYLQHLRELCTQHGALLIFDEVMTGFRVALGGAQAHYGVTPDLSTFGKIIGGGMPVGAYGGRRDLMQQIAPAGPIYQAGTLSGNPVAMAAGLAMLELVSQPGFHADLAERTARLCAGLEAAAAEAGVAVTTTCVGAMFGLFFTNEKVETYAQATACDIPAFNRFFHAMLEQGVFLAPSAYEAGFMSSAHDDAVIDATLAAARVAFKAAKG
>NZ_CP018756.1|WP_079223094.1|3246959_3247586_+|thiamine-phosphate-synthase
MTSASPAPRGVYLITPDEPDTARLLARTAPLLAAGATWLQYRNKTASDALRREQATALQALCAAQGVPLIINDDPALALAVGAAGVHLGGTDGDIPSARALLGPDAIIGASCYDQLANAEKAVAAGASYVAFGAFFPTTTKVTSSRAHADLLRQSAALGVPRVAIGGLTPDNVGPIIDAGADLVAVVSGIYAAQDPVATQRAFLAQFA
>NZ_CP018756.1|WP_079223092.1|3246700_3246925_-|rubredoxin
MAARESSPDYPMTDATPTTLRTWMCVVCGFIYREADGLPEEGIAPGTRWEDIPETWTCPDCGVTKDDFEMVEID
>NZ_CP018756.1|WP_079223091.1|3245814_3246660_+|tetratricopeptide-repeat-protein
MQDRITLPDWDALADVDDEALPLLPTALLIARDEYPDLQPGVYDALVQSHVDHLRAEVDTIERWPLKMAAVNRHLFDELGYSGDHQEYYDPRNSYLNQVFERRLGNPISLALVQMEVARRLGIPLDGVSFPGHFLVRLPVDDGVLVMDPFNGGRPLDVDELRERAKSHLGGQAPDDQVLAQILDPAPTRAILIRMLRNLHGVYAEASEWDRAARSADRLLKLAPEQDDALRDRGLAYLQLDYLAGARHDLGQYLRRNPEASDAQWLREKLIDLGGPMPRLH
>NZ_CP018756.1|WP_079223089.1|3245218_3245662_+|DUF192-domain-containing-protein
MSLRSLLILPLLALTGCATDAARHWVELDGARYQVELATNDETRARGLMFRDQMQADHGMLFIHDREEMQAYWMKNTKIALDILYFDSERKLVSQQRDVPPCSAGDMCPPYPSGGPARYVLELNAGQAEKLKLKDGTPLTFGPGIDK
>NZ_CP018756.1|WP_079223087.1|3244551_3245199_+|ribose-5-phosphate-isomerase-RpiA
MSEAKRLAAEKAIEYVQDGMIVGVGTGSTVAYFIDALARIQHRIKGAVSSSEQSTARLKQHGIEVIELNHAGTLSLYVDGADECDANKCLIKGGGAALTREKIIAEASERFVCIVDPSKQVPVLGRFPLPVEVIPMARSLVARQIRDMTGGQPTWREGVVTDNGNQILDIHNLEITDPEKLERELNQLPGVVCVGLFARRRADVVIVGGEPPVVL
>NZ_CP018756.1|WP_079223085.1|3244049_3244529_+|EVE-domain-containing-protein
MTARKRYWLMKSEPDAFSIDDLAKVKVEPWNGVRNYQARNFMRDGMQVGDGILFYHSNTKVPGIVGLATVASAAYPDDTQFDPASDYHDPKSTRENPRWMLVDVGFERKLKQVIALDEIKLHADELGEGFPLVAKGNRLSVFPVTAAQWKLLLSLEKKS
>NZ_CP018756.1|WP_079223101.1|3252507_3253458_-|YiiG-family-protein
MNASVRVLPVLLLGAVAGLAGCNNSTGLSLADPSLAKVNAYIECYNGVEQPIHEGFETYTGWIKDVEAGPTGKEAQPRSPGKVLSHRVEYCGQPLTDALAMAPATPMDASVRDYQQAFQALYAKIEQADGYFTREEFRRDGGEGMRSQHAPLMQAYAAFFKASDALDVALEKNEEDRRAAQLKQIEKSEGRSMAYYHLRLVGEGKQLAVAFQDEKPDVAALRTRLADYEALVKETQAAGIGKDDPMWGHVQRSAEMLIRKAGRGIERIEQGKPISAEGLAAERKASGSWLTSAPEGAQSDILDGYNDLVTTSNRMR
>NZ_CP018756.1|WP_152027112.1|3253491_3254526_-|YiiG-family-protein
MCGWNRFQQGRTPMRPMLRAATLAASLSLALAACGGKPAAPADAAANAGKGDTAAADTGADSDQALMGKLNGYIECYNDVDRKIHAGIGPYTVWMKDPEAGPTGREERPIGPPDLTAGDLKLCDKALPEAIAAQPSLPELDKAAQGYLDALHALQPITHEAADYYQRDDYEDDGFARGKALHAPLMSAFGTFVEASGVFSDALDVANDRLQDSQLAKVEAQEGRTRNFYRLAIMRDAKALMDLMAEDSFDVTEARRRLDAFNAISDEAHAKVAEQEPGKLDWNSFERTAENFRRESKERLKRVADKTPYSDIERRMLDTTMAPHGSPGKLMQEYNSLVFQSNRQ
>NZ_CP018756.1|WP_079223103.1|3254585_3255428_-|NAD(P)-dependent-oxidoreductase
MAYAGVWNVGSLQGKTLFITGASRGIGLAIALRAARDGANVAIAAKSSVPNPKLPGTIHSAAEAVTAAGGQGLALKCDIREEDQVKAAVAATVDTFGGIDILINNASAIWLRGALDTPMKRFDLMQQVNSRGSFLCAQACLPYLLQAPNPHILTLAPPPSLEPKWWGPHTGYTLAKMGMSFVTLGLAAEFGPQGVAVNALWPRTVIATDAINMIPGVDAAGCRTPQIMADAAHAVLVREAAGFHGRFLIDDEVLAEAGVTDLSAYAVDASRPLLPDLFLD
>NZ_CP018756.1|WP_079223104.1|3255512_3256193_+|hypothetical-protein
MRRSRLLLPALGLALLTACQGHSPEPGTEPATGDAPAANKAADGSLRWSESVVWDGDLNACRQGENNATRACLAETMKSAGASADAVAAAEQLSTGGELAYVTAWHEHDGLGVATVEYPFRANTNEGTRLVDAAGKRIDVDAVQLDDTLRADPGVQAVLAAHPQATPFAPAQAAGTAPLDGGGIRLLYRTPLRDCHACPDVGQLQIGYDFDGKRNFIGQQVVPAAP
>NZ_CP018756.1|WP_079223105.1|3256597_3257101_-|hypothetical-protein
MIDFDESADVAKTLAWYRSSFFEGCEEGFVADFMVFCWQTLDPGNVAATDLRGDLFDACAGQLRELLQSVEETCGPWSAPAFWKRYIEWADYATLFSIEDQREFAQHDPGYIEPAFSVFAFTGGQEMRAEAMTVLASCAASSTMRASYVRSVIESRLRVEAFAARTR
>NZ_CP018756.1|WP_152027113.1|3257226_3257697_-|hypothetical-protein
MLVGLKKIHRLLPMVLLLGAVESTAQVAAEGGGRCQDLTGAYEGVQYCQIPIHALLANSVDYRNRNVAVFGYLLHGEEGGDVLGPSADALRRIDFIACAAVDLDGVRYEDSSDVLEPGIYFAMVQGVYVDGAVNGACVGSIKRPIISRVSKVEEAD
>NZ_CP018756.1|WP_152027114.1|3257999_3258485_-|hypothetical-protein
MSVRAKQKWDIGSVFLLPLEDGDSCVGQVIGREAHVLNSAVIALFDFKGAWADGNIPSLGLDGLFSALFVTRDLLDSGRWKVIDVRDTGGVVEAAPYETLRRSGFIGAKVRGSGIVEEFVNAFYGLAPWDDWYVPDYLDAFLISASKKPTDHLVYSGRHAV
>NZ_CP018756.1|WP_079223106.1|3258608_3259115_-|DUF2867-domain-containing-protein
MSPSQVVTAPPSAASVLRAQLPGAGFVHACQARTRRDGRSALQAYRDMAATIPGWFDGLMALRNRGMRLLGMKDLGSLRAVQETEAPQPGQRLGIFTLQSLDEDAIVLEDNDRHLRVQLALQWQGDVLEVATVVHTHNAFGRVYMLPVAPVHRWIVPHLLRRQVQAYD
>NZ_CP018756.1|WP_079223107.1|3259111_3259774_-|serine/threonine-protein-kinase
MPHSTDAPTHALKADSFGRILLVQGPQGPFVRRDLGATPLWLRVPAWWLARREARALRHIHGMADVPQLLDWDGRHLDRSFMAGDAMYQRPPRGDLAWFRAARRLLQQLHRRGVAHNDLAKEANWLVTEDGRPALIDFQLAVIGHPRSRWMRLLAREDLRHLLKHKRMYCRESLTPVEKRVLKRTSWVRELWFATGKPVYRFVTRRILHWEDNEGQGPKP
>NZ_CP018756.1|WP_079223108.1|3259859_3261854_+|VTT-domain-containing-protein
MDSSWIDATLAWIAAHPVLAGAVIFLIAFCDAVIILGAIVPALPLLFAVGVFIGLGQISGPYAVAAAALGAFAGDGISYWIGRRWGDRLRGVWPFSRYPQLLDRGENLFRRNAFKSILIARYVGAIRPFVPAIAGMLKMPASRYVQASGIASLSWAVLFLAPGWILGEAYDAVAAVAGRLVVVVGLLMVILGLVWAIVLYGYRWSAARMDHWLARVLDWSNRHPTLGRYTVGVLDPKRRESVPLAMLALMLLLLGWGWFALLTVVVAHGEPLAIDLLVHQAMLALRNPLADYPMAALASLGAWQVLMPATAAAMGYLVWRRRWMAAAHWLAALAFGLALTKLLGTTVDVVRPVDASSGFGFPSVSVTMATITFGFFAVLIAREMPGRTRVWPYLVSGIVVSLIGFSRLYLGAHWLSDVIGGMLFGTFWLLVLGIAYRRRFNRSFWVKPVAWLFYGVFAVAAMWYAPRNIPVKLERFEPTLPAPTAIDMQAWWQHDWAKLPARRNEFDDDQRWPLDVQVAGPLAPLQAQLQARGWTVQAQAGWEEALLMLDKNTGADELPVLPATLETRVEALLMVRQGARPDERYVLRLWQAPGQLQPGDVPLWLGSAQTLRYERHFEWIGMWHPVRGIDPAFNAVKDAVQGMPQHEDVHAETGLPVLRLKTQP

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Crispr_ID: NZ_CP018756_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_24

3734828-3734946

Orphan

Consensus_repeat	Method
TGGTGGGTGCCGACCGTTGGTCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_24

>merge|NZ_CP018756|24|3734828-3734946|CRISPRCasFinder
CGGTGGGTGCCGACCGTTGGTGGTGGGTGCCGACCGTTGGTCGGCACGCCGTTAAAGCCGCCCGACCAACGGTCGGGCGCTACCGGTCGGTTTGGTGGGTGCCGACCGTTGGTCGGCAC

>NZ_CP018756|24|23|3734828-3734946|CRISPRCasFinder
CGGTGGGTGCCGACCGTTGGTGGTGGG	TGCCGACCGTTGGTCGGCACGCCGTTAAAGCCGCCCGACCAACGGTCGGGCGCTACCGGTCGGTT
TGGTGGGTGCCGACCGTTGGTCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079223804.1\|3737759_3739520_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NZ_CP018756.1\|WP_079223812.1\|3745205_3748193_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_CP018756.1\|WP_079223793.1\|3731164_3731527_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP018756.1\|WP_161490391.1\|3713536_3728584_-\|DUF11-domain-containing-protein	unknown	unknown	gnl\|CDD\|380078
NZ_CP018756.1\|WP_079223813.1\|3748255_3749272_+\|cupin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372651
NZ_CP018756.1\|WP_079223810.1\|3743708_3744716_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380487
NZ_CP018756.1\|WP_152027131.1\|3728693_3730850_-\|DUF11-domain-containing-protein	unknown	unknown	gnl\|CDD\|227002
NZ_CP018756.1\|WP_079223799.1\|3733119_3734067_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NZ_CP018756.1\|WP_079223784.1\|3707265_3708549_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NZ_CP018756.1\|WP_079223814.1\|3749380_3750955_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP018756.1\|WP_079223801.1\|3734070_3734757_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NZ_CP018756.1\|WP_079223786.1\|3708651_3709527_-\|RNA-polymerase-sigma-factor-RpoH	unknown	unknown	gnl\|CDD\|235838
NZ_CP018756.1\|WP_079223808.1\|3740835_3743367_-\|exo-1,3/1,4-beta-D-glucan-glucohydrolase	unknown	unknown	gnl\|CDD\|224389
NZ_CP018756.1\|WP_152027132.1\|3739628_3740696_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_025878607.1\|3737202_3737532_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP018756.1\|WP_079223795.1\|3731545_3732259_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP018756.1\|WP_079223815.1\|3751006_3751882_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223880
NZ_CP018756.1\|WP_079223797.1\|3732269_3733112_-\|response-regulator	unknown	unknown	gnl\|CDD\|381085
NZ_CP018756.1\|WP_079223802.1\|3734951_3736679_-\|ATP-dependent-RNA-helicase-RhlB	unknown	unknown	gnl\|CDD\|235307
NZ_CP018756.1\|WP_079223788.1\|3709836_3713478_-\|TonB-dependent-receptor	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079223804.1\|3737759_3739520_+\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NZ_CP018756.1\|WP_079223812.1\|3745205_3748193_+\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	4.50694e-167
NZ_CP018756.1\|WP_079223793.1\|3731164_3731527_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.25728e-12
NZ_CP018756.1\|WP_161490391.1\|3713536_3728584_-\|DUF11-domain-containing-protein	gnl\|CDD\|380078	pfam17963, Big_9, Bacterial Ig domain. This entry represents a wide variety of bacterial Ig domains.	7.34757e-08
NZ_CP018756.1\|WP_079223813.1\|3748255_3749272_+\|cupin-like-domain-containing-protein	gnl\|CDD\|372651	pfam13621, Cupin_8, Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.	1.8791e-79
NZ_CP018756.1\|WP_079223814.1\|3749380_3750955_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.34382e-60
NZ_CP018756.1\|WP_152027131.1\|3728693_3730850_-\|DUF11-domain-containing-protein	gnl\|CDD\|227002	COG4655, COG4655, Predicted membrane protein [Function unknown].	4.60797e-15
NZ_CP018756.1\|WP_079223799.1\|3733119_3734067_-\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	2.30935e-74
NZ_CP018756.1\|WP_079223784.1\|3707265_3708549_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP018756.1\|WP_079223801.1\|3734070_3734757_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	7.60998e-113
NZ_CP018756.1\|WP_079223786.1\|3708651_3709527_-\|RNA-polymerase-sigma-factor-RpoH	gnl\|CDD\|235838	PRK06596, PRK06596, RNA polymerase factor sigma-32; Reviewed.	2.35067e-175
NZ_CP018756.1\|WP_079223808.1\|3740835_3743367_-\|exo-1,3/1,4-beta-D-glucan-glucohydrolase	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	3.28674e-85
NZ_CP018756.1\|WP_025878607.1\|3737202_3737532_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	6.17923e-46
NZ_CP018756.1\|WP_079223810.1\|3743708_3744716_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380487	cd01545, PBP1_SalR, ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators. The SalR binds to glucose based compound Salicin which is chemically related to aspirin. The ligand-binding of SalR is structurally homologous to the periplasmic sugar-binding domain of ABC-transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.04157e-118
NZ_CP018756.1\|WP_079223815.1\|3751006_3751882_-\|hypothetical-protein	gnl\|CDD\|223880	COG0810, TonB, Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane].	4.66068e-07
NZ_CP018756.1\|WP_079223797.1\|3732269_3733112_-\|response-regulator	gnl\|CDD\|381085	cd00156, REC, phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs). Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	2.78078e-16
NZ_CP018756.1\|WP_079223802.1\|3734951_3736679_-\|ATP-dependent-RNA-helicase-RhlB	gnl\|CDD\|235307	PRK04537, PRK04537, ATP-dependent RNA helicase RhlB; Provisional.	0
NZ_CP018756.1\|WP_079223795.1\|3731545_3732259_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.99425e-148

>NZ_CP018756.1|WP_079223801.1|3734070_3734757_-|cell-division-ATP-binding-protein-FtsE
MSVLRFDNVSKQYAGGHEALTDVSFEVAPGEMLFVTGHSGAGKSTLLKLIHLDERPSRGAVVFDERNLLKVRGGDIPRHRRAVGAVYQDHRLLMDRSIAENVALPLILRGTRRGDIAKRVRSVLERMGLGHREKALPSQLSAGEQQRVGIARAIVGEPKLLVADEPTGNLDPTLAAEIMALFAELPSRGTSVLVVSHDLPLLRRMRKRVLILDHGRLADDISPQDLAE
>NZ_CP018756.1|WP_079223799.1|3733119_3734067_-|ABC-transporter-permease
MGKNENSEAAAPSRLGVWFHHHAHSVVFSLGRACRKPWATLLTVMVMALALALPLGLSIALDNLKQFAGSVQQSRDINVFLKADVDGPGALRLAGELRDRQDVANVTVRTPEQGLQELRDAGLGEAIDALNDNPLPSLLVVTPGQGQDDARLARALESLPGADLVQHDALWRQRLDAWLAFGARLVQVLSALLGAGAALVVGNTVRLDIQARREEIGVLQLLGASDGFIRRPFLYLGAWYGLGAGAVALALIGVAGAALRTPLAELSRSYGSPFVLHGLDLLHGSLVLLGTLLLGWLGAWLVTGHFLRQTRPTDT
>NZ_CP018756.1|WP_079223797.1|3732269_3733112_-|response-regulator
MQPQALKHLEGPATRVMVVDGSKLVRRLIADVLQRDLPGVEVIGCDSIEEAQKVLEQGPVDLVTTSLTLRDGDGLALAKRVREAAGQAYVPVIVVSGDAQQHLEQRRFTEYVTDYFDKALGHEALATFIRGYVQPQTIPGATILYVEDSRVVAEATKRMLERQQLNVMHVVSAEEAFTLLTAESLGRSRHRIDLVLTDVTLKGELSGRDVVQRVRVDFGYGKRRLPVLVMTGDGNPLNQTGLLQAGANDLVLKPIEERLLVTKVLFQLRLARLNDGPLLR
>NZ_CP018756.1|WP_079223795.1|3731545_3732259_-|uracil-DNA-glycosylase
MMDDVVDTPAIQLEPSWKQHVGDYLLQPQMRELSAFLRQRKAAGAAVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGRGQAHGLSFSVAPGVPVPPSLLNIYKEIEGDLGIARPDHGCLVPWAQRGVLLLNAVLTVEEGQAGAHQGRGWEGFTDHVVDVLNRERDGLVFMLWGAYAQKKGKVIDTRRHRVLKSPHPSPLSAHRGFLGCHHFSMANEYLQRQGQAPIDWSLPPRASL
>NZ_CP018756.1|WP_079223793.1|3731164_3731527_+|helix-turn-helix-transcriptional-regulator
MQAMCDRIRRARLTAGLSQTQLALHCGVRRSAVAQWERDGGTVPSVQHLSKLAIVTQVHFEWLATGRGPGRPEDGELAPPENAAVEAGRSPQENAILSLLRRLPPRKRQVAHAIIEMLTE
>NZ_CP018756.1|WP_152027131.1|3728693_3730850_-|DUF11-domain-containing-protein
MVNVKGVKASSLRWQALVMLVVLAVLSCLGRAQAQSACTAGACVSAGPRLVSVDSTQSPILNLLFSALLPGTSLTLSVADWNSLAGANVNLNALLTQLNGGVTVSDPSQVLNTNITLGQLRAAMVQVLQADGQTAAANVLNVLPLGVAGTSGSIRLADILQVALPTGSLATVRLNVLDLLTGGVQLYNFRNVLTTPTPITVNTAALGLNGVANVRLWAQVIEPPSYNCGTVGAAFHSAAIRIKLDLDLVQGLNTGTLTAALNGLNLLGVSLSNTSISADVLHLQVYADVARAEGSISAVNLVGNAVTLQARPGLVNLYVGQISDATFFNRSTVLTETALTTATLTNLSVKVRVGVTLLGATVPVADITIPIAVGIRGFATATPGLQSASFTGPYPQTRTLTAGTVSAATLVSTLVNSLNIQLISGNPQVTLLGSLSLPLPVADLVNGIVNTLLTPVRTLVNAVVTPVLTAVLGGVVDNLLALLGIRVGQAVFTVEGVTQACAATLQLVKDLQPTSDTGRFNLSITYNGSTVGSASNVGNNGATAAIITVPGGSYALAEAAAAGTTLTRYASTWQCTDQNNTVVSSGSGGSFTLQAPAMTATATTLVCRITNRTRQADLSITKSDGSGTYTPGGTATYTLQVVNNGPDAVTNATVTDTLPNGTTLRGAWTCSATSGSTCAAASGGAAGGNAVNVGVNLVNGGQATISVPVSFSNNPGAY
>NZ_CP018756.1|WP_161490391.1|3713536_3728584_-|DUF11-domain-containing-protein
MAAVGRQGRAGRASAGIAHAMAVLALLLPPPLLAQSYPNPLNNTATVTAPTDVADPTPGNNSATDTNALALQAQLSVSKTLVSASPVAAGGPVQYRIQVNNAGPSAASGVGVVDTVSSLLTNVAWTCQPTTAASSCAQPSGSGNAVNVLVSVGVGDSVVLLVNGTAPAATPATVPANSVSLVLPSGTTDPTPGDNSATTPAVPVQANALVAANDSFTTPISSTTGGSTPTVLGNDTLNGQPVVGGNLIISLQNAPAGFTINSAGVIAVPAGAAAGATSIGYQICENASPTNCATATASLVIAPTAVADSYNVNAGTPSLTGNLAANDNAPAGATYSQTGTPVAGATISSTGTLTYAPAGNIGQPVQINYQVCLPAPNASVCSTAIASVVVDANVLVANDDTFAAPLLPGAGGTTPSVLGNDTFDTAPVTPAQVTLSLVGAPSGFSINPNGTIVVPASAAAGPRALTYQMCDANAATNCATATANLVVSPDAVDDAVSTPGGGRPVTGTLAGNDNFASGSVFTLGTQATRGTAVVNADGTFTYTPANASTGPDTFTYQLCLPAPNATVCDTATVTVSVAANQLAAADDLFATPLQPGTTTAVSLLGNDTLNGTAVAPAGVSLALSGAPASITANAAGQLQVAAGAAAGAYAFTYQICELPGGTNCATANVQLVVAPDAVDDSFTATAGVALGGSVAGNDNVPAGSQFSLLAGAAHGTVSVAADGGFSYTAQGTYSGADSFRYQVCLPAPNGGICDAATVTLNVAVAAVVAGNDDFSAAPVPGTGGTTASVLANDTLNGVAINAAQATLSLINAPPAGFTLAPTGELQVPAGAPAGPLSLTYQLCQAGTSNCATATIAVVIAPQAVADSFTTQVGRAVSGNVSVNDRVAAGSTYAVTGTAPQGLVFNADGSFTYTPPAQFTGTTTFSYQACLAAPFNTVCSTATATINVNAGTLVANDDDFRGSLLNPATGGTTISVLANDTINGAIPPAPAEVILSLLGAPSGYVLNPNGTISVPGAAAAGAVNFGYRLCEAELPTNCDDGAVQLLLAPVAVNDNVSTAVGVPVSGNVGSNDNVPAGATFSVTGTAPAGLVLAAGGAFTYTPPAGTQGIVTFAYQACLPAPNGTVCAGATVTLNVNAGTLVAGDDDFRATPIGAGGGSTLSVLLNDSLNGTQPPASADVLLSLVGAPSGFTLDASGVLNVDAGVPSGALTLTYQLCETALPSNCDSAQIRLVVSPTAVADVFSTPAGQLLSGSVASNDNAPVGAVFTVSGTTPDGLQLGRDGTFQYTPPAGFTGPVSFSYQACLPAPDGALCSTAGATINVNAGTLMAMDDDFSATPLAPGATSSTSVLVNDSLNGGVPPPAGSVTLALVGAPSGYALTTAGLLQVPASAAAGATVLSYQICETAAPGNCASASIRLVVTPSAQNDSYSTAAGQPLNGSVGDNDNVPAGAVFTIVGATPAGLSFGGGGSFTYLPPVNAASPITFTYQVCLPAPNTALCATATASINITVGSLAANNDDFSSAPINPVTGGSTPSVLLNDALNGSTPPAAADVLLSLAGAPAGISLNPDGTVSVAAGVPAGGRTLTYQLCEAAAPGNCATATLRLVVAPSAVDDALSTPAGVDLASSVAGNDNVGSGAQFSVVGTPPPGLQFNADGSFIFAPATGFSGAVTFSYQVCLAAPDSGACATATATLNVNSGTLVAVDDTITAPVAAGSATSSVLGNDTLNSATPAADEVVLSLVGAPSGFSIAADGTIAVATGTASGAISLTYQVCEAAATTNCATANVALVVAPAPANDAFAVQAGLSVTANVASNDGMPVGSTFALQGTPPAGVTFNADGSFTYAPPAGTTSPTSFVYQACLPAPNSAVCATATATLNINNGALLANNDSFGAIAPGGTTASVLANDTLNGISPPAPANVALTLVGAPAGFSISPTGTVSVPADAASGATTLTYQVCETAAANNCATASIALVVRPTPQNDTISVQAGQANTGNVAGNDAMPAGSTWNVPSPPQGLVFNANGSFTYTPPAGTLGPVTFSYQACLPAPDAAVCGTATATLTIAVSAIVATDDAFAAPLTAGSVTPSMLANDVLNGVTPPPSAAVQLLLVAPPAGFIINNDGSVQIPASAPAGATTLTYQLCETASPTNCATAAITFVVTPAPQADAFAVQAGASLTGASVATNDNLPPGSSWAVQGTPPAGLAFTADGSFNYTPPVGTLGAVTFTYQACLPAPNTAVCSTATATINVNTGTLAAANDSFSGIAAGGTTASVLANDSLNGTPPVAASVQLSLVGAPAGFVINPDGTIAVPGGVLSGATTLTYQICEAAAPSNCDTATVALVITPSPQADAYSVLAAGTISNGNVAANDNLPTGSQFSVQGTVPAGLSFNNDGSFTYTAPANTPSPVTFTYQACLPAPDAALCGTATVTLNINDGTLVAADDSFTVAPGGSSGTSVLANDALNNVSPPAAGTVLVSLVGAPAGFVLAADGVLTVPAGIVSGPLTLTYQACEAASAGNCDTASIALVILPAPQADVFGVQAGQVLSASVAGNDNMPAGSSWTVQGATPAGLVFNTDGSFSYTPPSGVTGAVTFLYQACLAAPNAASCATAQATLNVSNGTLLAGDDTLAGIAPGGTSAASVLANDSLNGVSPPAPGDVVLSLVGAPAAFTLNPNGTITAGSGAMSGPTTLTYQICEAVAPGNCANASVTVVVNPAPQDDAAAVQVGQSLSASVASNDNMPAGSSWSLPGTPPAGFSFNADGSYTYAPPAGTSGPVVVAYQVCLPAPNANLCGTATLTLNINNGALVAADDTLSGVVAGSTSSTSVLANDSLNGVSPPADATVVLSLVGAPAGYAITPQGTISVPSSAVSGPVTLTYQICEAAAANNCDTASVIVVVRPSPQPDAFAVQVGQTLSDSVAGNDNVPPGAQYSVQGTAPDGLVMTATGAFTYTPPAGRLGVVTFDYQVCLPAPNAAVCGVTTATLTINNGTLVAGDDSFSNIAPGSTVGTSVLANDSLNGVSPPAAGTVTLALVGAPAGFSISADGLVTVGTGVQSGPTTLTYRICEAASPANCDTASVLVVVSPAPQPDAFAVQAGQTLANSVAGNDNMPVGSTWSVQGTAPAGLTFDANGSFTYAPPAGTAGPITVTYQACLPAPNAALCGTTTFTLNINNGDLVAGDDVITGVVAGGTSAASVLANDRLNGASPAPAADVRLSLVGAPAGFTLNPDGTITVGSGVLAGSTTLRYQLCEAAAANNCDTASVTVVVSPTPQADAFSVQAGQQLVNNVAGNDNMPAGSTWSVQGTAPAGLVFNADGSFSYTPPAGTLGAVTFSYQACLPAPNGSVCGTATVTLNVNTGTLLAGDDSFSNIAPGTATPSVLGNDSLNGVTPPAASVSLSLVGAPTGFGINPDGTISVGSGVVSGSTTLTYQICEVAASSNCATASVNVVVSPAPQADAFSVQAGQSVNNNVAGNDNMPAGSTWSVQGTTPAGLVFNSDGSFSYTPPSGTTGPVSFTYQACLPAPDAALCGTATVTLNVNSGTLVAGNDSFTGIAPGTATPSVLANDSLNGASPPAAGSVTVSLVGAPAGFTIAADGTISVGTGVTAGTTTLTYQVCEAAASSNCATATVTVVVSPTPQPDAFSVQAGQVLSNTVTGNDSMPAGSSFSVQGATPAGLVFNTDGSFTYAPPAGTTGVVGFTYQTCLPAPNAALCNTATVSFNIGTGTLLAANDSFSGIAPGGTTSSVLANDSLNGVSPPAAGTVTLGLVGAPAGFAINADGTISIGGGVTSGATTLTYRVCEAAAPSNCATATVNVVVSPVPQADAFSVQAGQTVSNSVAGNDNLPAGSTWSLQGTAPAGLVFNADGSFTYQPPVGTTGAVTFTYQACLPAPDAALCGTATVTLNVNTGTLVAGDDSFPGIAPGGTTPSVLGNDSLNGVTPPPANTVTLGLVGAPAGISINPDGTISIGSGVPSGPTSITYQVCEVAAPSNCANATVSVVVSPAPQPDAYSVRAGQVLSNTVAGNDNMPAGSTWSVQGATPPGLVFNADGSFTYTPPAGTLGAVTFTYQVCLPAPNAAQCGTASVTLNVNTGTLVAGDDSFSGIAPGGTTPSVLGNDSLNGTSPPAAGTVTLTLVGAPAGFGINPDGTISIGTGVTSGPTTVTYQVCEVAAPGNCATASVTVVVSPAPQPDAFSVQAGQTLANSVASNDNMPAGSVWSVQGTAPAGLLFNADGSFTYTPPVGTSGPVSFTYQVCLPAPNAALCSTATVTFNVGGAANVVLAVNDDFSSTPVDPSVGGTIARSVLDNDSFNNVSPPPVGSVVASLTGSTPGYTMNNQGQIMVAPGVQAGQVQLAYQLCENGVPTNCTTAIATVLVQGPVGALLAVDDTGGPVGPEGRTRLLNVFANDTFNSAVLDPAQVNFVPVATNALTFSADGWVDVAAGLAPGSYSTTYTLCLVNQPTVCDVGTVTVTVIAAEPGVVAEDDQVNLPQDGVVEIDVLGNDRMDGTPVDPSGVTVTITSPPPYGDATVLPDRRIRFAVRAYFSGVQTFEYQVCDATDPSMCATASVTITVDANVLTLVDDAVTAETSGPLLINVLANDTTRSAPLDPASLQVAAAPAHGTVQCANGVCTYTPAADFSGTDSFRYRVCDLSVPTPLCAEANVAVTVAGQQAVLRLTKVAAKRSAQIGDLVRYTVTIDNVGEVDANGATLLDTLPPGFTFVSGGFAVRDADNDARTSGVQPLRIDGIDVPVGERATVVYYLRVGAGTGTGVHTNRITAIDGQNRSIGNVATADVDVSVDPLLDESLIIGSVFDDRNGNGIQDDGERGIPGVRVAAVEGLVMETDAFGRYHLVGIPGGEARGRNFILKVDPSTLPAGARFTTPNPLVRRITPGLPARFDFGVHMPDGALSREGTPAAVVPRPARVELGQALFAPGSATLAADRASVLDKAAQALLARGGGRVLLVATAGEEALAQQRAQAVRGALASRLPAYVAAATRIEVHGGDGRVLQQLTIEPPSGPPPAGPNSGEGR
>NZ_CP018756.1|WP_079223788.1|3709836_3713478_-|TonB-dependent-receptor
MSCSVFALLLAAPPVLAQQAAPMASSDVRCEGDTCRSDDGELLRIGDDADTPLLPLPGQADPTAASSVPLAPAVTPDVSARGGQFMAELPNGGVVWATEDPSMVPPSLSVQAAATVPFENGRVIRPLRFHSYNNYASFIEKLEVTLYRGTDTDLVTPLARIELPSDYVGDAEWDGTVPEQFKLRTGDELIYVARAYGAGGSFDETQIQRIQLVTPADFDRGLQVTRDNVQKTLGQALDGASAQDLQVSNSIYGQSMLRLQNIPIHGSRVRLYGRNLEPNSRVRINGQDFPVDLEQKFAAEFLEPVGQHRYDVRVESRDAPSAQRQLDVDVTGRYLFLVAIADVTLSKNSASGNVQPLAADDRDTDGFLSEGRLAFYLKGKMRGKYLVTAQADTQDRELKYLFRDFSRADAQDVFRRLDPDLYYPVYGDDSTTYRDVDTQGRLYLRVDWDQSQALWGNFATGITGTEYGQYVRSLYGGALNWRSLSATPLGEARSQLKVFGSEAQSAPGHSEFLGTGGSLYYLRHTDLLPGSEQVVLEVRDRTTGRTETRATLQEGVDYEIDDLQGRLILTRPLAQLTRENVRSITRDMPLDGYDQLLLVDYEYVPLGFSSDDVTYGARGRQWIGDHVAVGGTWVEENRSGENYSLKGADLTLQAGRGTYLKMEQTRTDATAAPVFYSDNGGLSFIRRNPYEGRRSGKASAVEARANLRELGWTSQDWSLGAWWRDVDAGFSVARQDTGLPIQEYGAEFLGYLTDDFSLYGRHTRTEQGELALEQSQLTAEWRLGNDGQLTGELRRVREEQELQDVSALLAAIGYRQRFGSSWELYGTGQVTLDDDGGAYEKNDLLTLGARYLFGDRSSVGAELSGGSRGHGGKVDAEYRMAPDHSLYGSYSYSTDRTGTDPLFDSGLQSGWTVGQRWRLSNQVNVYNESQYLKDRRQDSAGLVHTFGMDFYPAQGWNLGFTLMDGELESTVGRINRRAYSVSGGRTDAVAQWNSKLEYRRDSGAEQREQWVTTNRLLYKLNEDWRFALRANYADTQDRINPVADAKLVETNVGFAWRPHDNTRWAGFGKFTYLYDVASLGQEGGNLYDQRSQVLSLEGIRQIGERWEMAAKLASRWGDYRTGRGEGAWLDSRADFAALQLRYRLFAQWEGLAEHRWLKVRDGGVRKGWLLGVDRRVGENFKVGVGYNFTEFSDDMTELKYDQKGFFLNMAGYY
>NZ_CP018756.1|WP_079223786.1|3708651_3709527_-|RNA-polymerase-sigma-factor-RpoH
MSQNTSTALVANNLPIPSALGSLDAYIGAVHQIPVLSVDDEQDLARRFRDGDDLDAARELVHSHLRFVVHVARGYNGYGLALGDLIQEGNIGLMKAVKRFDPDMGVRLVSFAVHWIRAEMHEFILKNWRIVKVATTKAQRKLFFNLRKSKTRLGWMNAAEVSAVAKDLNVSEREVMEMESRLSGRDIGFDAPTDEDNDHAPPSPAAFLVSNDEDPSMAYEREDSEDNQMQLLREGLAELDARSRDIIRRRWLDADSKVTLQELADEYGVSAERIRQVEANALKKMKALFTA
>NZ_CP018756.1|WP_079223784.1|3707265_3708549_+|phosphoribosylamine--glycine-ligase
MNVLVIGSGGREHALAWKLAQSSRVTEVIVAPGNAGTATEDKCRNVAVKVTDIDGLLALAQAEGVALTVVGPEVPLVAGVVDRFRAADLRIFGPTAAAAQLEGSKAYAKDFLARHNIPTAFYAVHTEVDAALAYIREKGAPIVVKADGLAAGKGVIVAMTQAEAEDAVRDMLSGNAFGDAGARVVIEEFLDGEEASFISMVDGVHALPMATSQDHKRVGDGDTGPNTGGMGAYSPAPVVTPEVHARVMREVVNPTVQGMIADGIPFTGFLYAGLMIDASGAPKVIEFNVRFGDPETQPVMLRLQSDLVDLVEAAIDGRLDAVDAQWDPRPSLGVVLAARPYPEAPITGDVISGLDAVPANAKVFHAGTTLDAQGQVLSAGGRVLCVAALGDSVRDAQANAYAGVAKVTWANEFHRTDIGWRAIAREG
>NZ_CP018756.1|WP_079223802.1|3734951_3736679_-|ATP-dependent-RNA-helicase-RhlB
MSDKPLTDLTFSSFELHPALQAGLEGAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVVNRLLTRPALADRKPEDPRALILAPTRELAIQIHKDAVKFGSDLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERTTRQTLLFSATLSHRVLELAYEHMNEPQKLVVEAETITAARVRQRIYFPADDEKIPLLLGLLSRSEGARTMVFVNTKVFVERVARSLEKAGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGIKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMGLPDIEAYIEQKIPSEPVTKELMTPLPRPERPAPAEGEEGDDNESVGQIFREAREARAAEEERRGGGRSGGRSGSGGGGRGGRDGERSGERRPRGPRKPRVEGEQGAAAPVAGAEGAAAQAPRPPRPPRAEGAPEGAADGEHKTRKRRRRRHGRPVEGAEGAQNTAGNGASPVTPVQVVAKPVRTAADTGDSFLTRIGRKIRRMLSGN
>NZ_CP018756.1|WP_025878607.1|3737202_3737532_+|thioredoxin
MSDKVVHVGDADFDSAVLNSKEPVLVDFWAEWCGPCKMIAPALDELADAYQGRAKIAKVNVDNNRALAAKYHVRSIPYLVVFKDGEKVGEQIGAVGKAQLAGLLDKALA
>NZ_CP018756.1|WP_079223804.1|3737759_3739520_+|transcription-termination-factor-Rho
MSDNTPETGSADAPAEKRVRKPRVSKAAAPAAAETSAAPAQPTLPLAPAPEAPAPAAAAPAPSAPAAEAPASGGGDGGEGRESGQPRQQNHQGGQGGGQNQGQNNNPYNQGGQNGQQGQGNRRDRFRNRRDRDRGGRGREDGMPQDSGEQQPFVPRPHANVPEGFPVYSLSDLKRMPAQKLLEIAEQLQISEGVARARKQDVIFALLKVLTRHGDGVAADGVLEILPDGFGFLRAAEASYLAGPDDTYISPSQIRRFNLRTGDHISGRIRFPKDGERYFALNIVDTINGEPIEASKNKVLFENLTPLFPRRRFTLERGNGSSEDITGRILDLMAPQGKGQRSLIVSQPKAGKTMMMQQVATAITTNHPDVHLIVLLIDERPEEVTEMQRTVRGEVISSTFDEPAARHVQVAEMVIERAKRLVEHKKDVVILLDSITRLARAYNNVVPSSGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALVDTGSKMDEVIYEEFKGTGNSEVHLSRRIAEKRVFPAIDINRSGTRREDLLIEPELLQKIWILRKLLHPMDEMAAMEFLLDKMKNTKSNDEFFGSMKR
>NZ_CP018756.1|WP_152027132.1|3739628_3740696_-|hypothetical-protein
MRRLLQSVRLQPHGSTIDVTCVTDARALLELVRQGAYAQASAVMAELHEGSQVDFYAYLGKQVQAPALAAQWHAHAPDSIDATLLLAFAELGEGWRLRGETYFHEIPEARRRAFPLKFQAAQRLFKALAERADAPPLAFYGLLHCDVVCDIEREARSERFAQVMALAPYHAPSVYMLAKASMEKWDGSDEEMWAYLRWISDNAPRGRDAHAAIAAHVVEWTYPWMDECDAPLEIVGVVRTANVPGLADLVRKALLDWLDVQPAGLERALAACTSSRERRHRAEFALALYLVGAWDEARVVMKAQGGKVPVEPWCYLAYRGSSMLSEMLGGTLRCAGLAHDRICRDLGLDPREVCA
>NZ_CP018756.1|WP_079223808.1|3740835_3743367_-|exo-1,3/1,4-beta-D-glucan-glucohydrolase
MNRPTQTLLASCLLAALAAPVGAAPASGERLQDWPRVHSAITTDAQIESRVQQILSQMTLAQKIGQMTQAEIKTITPEQVRRYYIGSVLNGGGSWPGMDKHASVQAWLELADAYHAASLATDAKTPVPVIWGTDAVHGHNNVLGATLFPHNIGLGAAGDPELIERIGEATARSVRATGIGWVFAPTLAVAHDPRWGRTYESYSSDPAVIRSFAHAYVKGAQGAFKDDGNVITTAKHYLGDGATDSGRDQGEALVDKATMINVHAQGYYGALAEGAQTVMASFNSWNDRAAGIDYGKMHGSKALLTDALKDKMGFDGFVVSDWNGIAQVPGCRNDSCAQAINAGIDMVMVPDDWKAFIDNTTAQVQKGEIPMARIDDAVTRILRVKLRAGLFEHKPSDSRYAGDASAVQHRELARRAVRESLVLLKNEGKVLPLRRDARVLVVGKGADNIGDQSGGWSLTWQGTENRNADFPNADSVLGALRAELGTDKVSFSADGQGIDPKAFDVVLAVIGETPYAETNGDILASDTVSHSRAYPQDLAVLKAAASAGKPVVTVYLSGRPMYTNDLLNLSSAFVAAWLPGTEGKGVADVLVAGKGGKPAHDFRGRLSFPWPGVPCPAPIDQPDAKKPSLFALGYGLSYAKGGKVARLDEANPDSCGEVTVLPIFNRADTPPFALHVAAAGATQPLGSDLNATLRWPTAKPVVQVRTVQVNTQQDAKEVTWLAPAQLIARSTSRRNLGALARSNGALQFDVQLVKRPASPVKVTMQCGSGCEGGVDIAPLLGKLSPGQKQTVTVPLACFAKQGVALGAVEAPFVVTADKPFAAAFTQVKLTANTANAEGAVACP
>NZ_CP018756.1|WP_079223810.1|3743708_3744716_+|LacI-family-DNA-binding-transcriptional-regulator
MRSRIEDVAAVAGVSIKTVSRVLNHEPNVREQTRERVLAAVARLGYKPNLSARSLAGQRSYALALVYNNPSRNYLMEIQSGMLEACHAQHYNLILGPVGTGRRTLPDLAALFENSRPDGVVLIPPLTDDEVVLSWLEEQDIPFACIAPRHPEGRIGVRMDETTAVVELIGHLVAQGHRRIGHIKGPRAHGACQWRHAGYRQALREAGIAYDPQLVANGQFSFESGVDAANVLLDLDDPPTAIFAANDDMAAAVYRVAGERGLRVPRDLSVCGFDDTPIAGHIYPALTTVRQPTAHMGRLATEQLIEHIRAEAAGRMITVEHAVLERESTAAPRRR
>NZ_CP018756.1|WP_079223812.1|3745205_3748193_+|TonB-dependent-receptor
MKTYKAVPRKTMLTSALLAALAAPAWAQDAPAGDTPDPATLDTVQVTGIRGSLQSSMNLKRDSQGVVDGIVAEDIGKFPDTNLAESLQRISGVSIDRTSSGEGSKVTVRGIGPDYNLVLLNGRQMPASNLGNGGAGLNGSRSFDFANLASESISAVEVYKTSRADNPAGGIGATINIKTLRPLESEPVISLGLKAVNDSSNDNLPRTLQGSNVTGELSGIFSQRYADDRFGVAFSASHQERDSGFNQATVAEGWATFYGNNTSDGRTLPQPGQGYSDRITNRPGPNDVYGRPQNTAYNVNGVQRQRTNAQATFQWKPTDNVTTTLDYTYVENKVQQQRSELSVWFNYGPGDSTWTNGPVAAPIIYSEDMTNSDVSMGGARLATKTGMHSLGFNVDWEVNDALDLSFDAHNSTAESQPDSPYGSAGVLGVAAFVRGKTTVDYSGDLPIINIALPPGGVQASDALVTGSVFQNSYNKSEVQQYQGRGTFRFADYSALDFGIGHTQVENRSASAIMQRNTWGGLGSPADYADDIWYADNMAKYFKAFSGHSDPRLTGQFLVFDFDRLIDRAGQVGTAADPACPTCYYAPSEYSEDIRTTEKTRSAFLQYRTTFDWSMPLHVAAGVRYEQTEVESNAMVRVPTGISWGSANELNIVYAPESSFVGGRGKYDYVLPNVDLKLDLSESLALRGSYSRTLGRPSWTQIQSGQSLADIVRTQGGSGSRGNPSLEPLISDNFDLSLEWYYGEASYASAGFFRKNIKNFISDTVVRENSGNLHTPVGGAYWNEALASCGGTDMPCIRDYIFTNHAGDPGVNFTGVNSAGQLTGTIEGLPTDPIAGFDITVPANQHSDHLDGWEVAVQHLFGQSGFGLAANYTKVKSGLTFNNLSLGDQYPMIGLSDSANLVAFYDRNAWQVRAAYNWRDKFLNGIGGQGPNPNYTAAYGQLDLNISYAVSEQLTLSLEAINLTDETMRTYSRHTNMLRYATQTGPRYMFGVRYKF
>NZ_CP018756.1|WP_079223813.1|3748255_3749272_+|cupin-like-domain-containing-protein
MLPQPRPIEEIHGLDPAQLHAQLPTWTTPKVIRGLVAHWPLVSAARRSAAEAVAHLAGFDHGQMPVTATTAAPDTHGRLFYNEDMSGFNFRREQIPLKVVLATLLKYASDPAPPSIYVASTTLDSFLPGFSQANPLHLGVADPLASIWIGNRSRIAAHQDVPDNLACVAAGRRRVTLFAPAQVENLYVGPLDFTPAGQAISMVDFHAPDLQRFPRFAQAWEQALVAELEPGDAVFIPSLWWHHMEGLEPFNVLVNSWWRPVPAWMDSPMNALMLAILALRDLPPEQRAHWRTMLDHYVFDAGEHTAAHVPQDARGVLAPLDAAGAERVRDTLRRRLQR
>NZ_CP018756.1|WP_079223814.1|3749380_3750955_+|GGDEF-domain-containing-protein
MPPISNRLNLGKLILALALLSTLIALGNTLLASYRVQRDQLVSNTLEANRVYTSKLAETTQTFLLSAQQQLAYAATRLGESGLDAGHAQDEASRLQLQSSSFNSSLVVNASGLVIATSPQTLQLQGEVLKSFGSNQALARRQPLISDPYQSATGKLLISLSHPVFDRQGTYLGYVSGTLYLRQRSALHTLLGKHYYRDGSYLYVVDHNGRIIYHNNPKEVGTYALDNAAVKAVMGGRSGSQQLVNNHGVAQLSGYAPVPVTGWGIIAQRPTEATLQPLSRLMSSVIWNAIPLGVLSLLITWWFARRISMPLWQLARNVQEGEDTGNAINHVTGIRAWYFEVAQLKQAVLYSFNALQDRIGTLNRASRTDPMTGLLNRRGLQNALEMLQAQGQPFAIVALDIDRFKSINDGHGHDVGDAAIVHIAEQMRRHSRETDVLCRAGGEEFLVLLPGVGVTAAQQTAERLRQAIAGQPFAPVGNITVSLGVAHFPTFHADVEQALRLADKALYLAKEQGRNRVVVYPHAE
>NZ_CP018756.1|WP_079223815.1|3751006_3751882_-|hypothetical-protein
MMRSSLFLALTLALGGGAGCIGNADAQSVREVRKQMEASMTLSGVINIGREGQVEGFQLDHRDKVAADVARLVEGTVNSWRFEPVLVDGKAVRARTDVRLRLLADSLTGTTMQVRVADANFGPVDEENTLSSDNVRALKMRPPVYPERAAAIRGQGEVTLLVKVGRDGKVADVVAERTNLTVVAPERQMQMLRDVLAKASVSTARSWTFSIPTTGEYKDEEFWTVRVPVNYAFDSRSERYGRWSAYIPGPRQQAPWKTGEDEKATGSDLLPEGGVYMVGRNDGPRLLTPLG

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Crispr_ID: NZ_CP018756_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_25

3776451-3776550

Orphan

Consensus_repeat	Method
CATGCGGACCAACGGTCCGCACCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_25

>merge|NZ_CP018756|25|3776451-3776550|CRISPRCasFinder
CGTGCGGACCAACGGTCCGCACCTACCGGGGCGGTTTCCATGCGGACCAACGGTCCGCACCTACCGGGGCGGTTTCCGTGCGGACCAACGGTCCGCACCT

>NZ_CP018756|25|24|3776451-3776550|CRISPRCasFinder
CGTGCGGACCAACGGTCCGCACCT	ACCGGGGCGGTTTCCATGCGGACCAACGGTCCGCACCTACCGGGGCGGTTTC
CGTGCGGACCAACGGTCCGCACCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079223826.1\|3761038_3761857_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl\|CDD\|236986
NZ_CP018756.1\|WP_079223848.1\|3779672_3779960_+\|CD225/dispanin-family-protein	unknown	unknown	gnl\|CDD\|377375
NZ_CP018756.1\|WP_079223831.1\|3768686_3771809_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP018756.1\|WP_079223837.1\|3776682_3777477_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP018756.1\|WP_079223857.1\|3782389_3783295_-\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|225373
NZ_CP018756.1\|WP_079223830.1\|3765421_3768655_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|182501
NZ_CP018756.1\|WP_079223835.1\|3774264_3776445_+\|TIGR01666-family-membrane-protein	unknown	unknown	gnl\|CDD\|130728
NZ_CP018756.1\|WP_079225399.1\|3762600_3763920_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349917
NZ_CP018756.1\|WP_079223855.1\|3781357_3782245_-\|regulatory-signaling-modulator-protein-AmpE	unknown	unknown	gnl\|CDD\|226248
NZ_CP018756.1\|WP_079223850.1\|3779993_3780275_+\|CD225/dispanin-family-protein	unknown	unknown	gnl\|CDD\|377375
NZ_CP018756.1\|WP_079223824.1\|3760505_3760799_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|236880
NZ_CP018756.1\|WP_079223822.1\|3757365_3759588_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|377178
NZ_CP018756.1\|WP_152027133.1\|3780878_3781319_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223860.1\|3783825_3784293_-\|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl\|CDD\|224578
NZ_CP018756.1\|WP_079223852.1\|3780322_3780748_+\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_CP018756.1\|WP_079223859.1\|3783401_3783794_-\|iron-sulfur-cluster-insertion-protein-ErpA	unknown	unknown	gnl\|CDD\|184186
NZ_CP018756.1\|WP_079223833.1\|3772062_3774120_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP018756.1\|WP_079223828.1\|3764105_3765347_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|183194
NZ_CP018756.1\|WP_079223839.1\|3777600_3779490_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|235865
NZ_CP018756.1\|WP_079223823.1\|3759936_3760446_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079223826.1\|3761038_3761857_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl\|CDD\|236986	PRK11792, queF, 7-cyano-7-deazaguanine reductase; Provisional.	2.59434e-177
NZ_CP018756.1\|WP_079223848.1\|3779672_3779960_+\|CD225/dispanin-family-protein	gnl\|CDD\|377375	pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.	3.46046e-21
NZ_CP018756.1\|WP_079223831.1\|3768686_3771809_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP018756.1\|WP_079223837.1\|3776682_3777477_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.36388e-61
NZ_CP018756.1\|WP_079223857.1\|3782389_3783295_-\|NAD(+)-diphosphatase	gnl\|CDD\|225373	COG2816, NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair].	2.03176e-71
NZ_CP018756.1\|WP_079223830.1\|3765421_3768655_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|182501	PRK10503, PRK10503, MdtB/MuxB family multidrug efflux RND transporter permease subunit.	0
NZ_CP018756.1\|WP_079223835.1\|3774264_3776445_+\|TIGR01666-family-membrane-protein	gnl\|CDD\|130728	TIGR01667, Uncharacterized_protein_HI_1680, integral membrane protein, YccS/YhfK family. This model represents two clades of putative transmembrane proteins including the E. coli YccS and YhfK proteins. The YccS hypothetical equivalog (TIGR01666) is found in beta and gamma proteobacteria, while the smaller YhfK group is only found in E. coli, Salmonella and Yersinia. TMHMM on the 19 hits to this model shows a consensus of 11 transmembrane helices separated into two clusters, an N-terminal cluster of 6 and a central cluster of 5. This would indicate two non-membrane domains one on each side of the membrane.	0
NZ_CP018756.1\|WP_079225399.1\|3762600_3763920_-\|amidohydrolase	gnl\|CDD\|349917	cd05667, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of bacterial proteins that have been predicted as N-acyl-L-amino acid amidohydrolase (amaA), thermostable carboxypeptidase (cpsA-1, cpsA-2 in Sulfolobus solfataricus) and abgB (aminobenzoyl-glutamate utilization protein B), and generally are involved in the urea cycle and metabolism of amino groups. Aminoacylases 1 (ACY1s) comprise a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and is a highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NZ_CP018756.1\|WP_079223855.1\|3781357_3782245_-\|regulatory-signaling-modulator-protein-AmpE	gnl\|CDD\|226248	COG3725, AmpE, Membrane protein required for beta-lactamase induction [Defense mechanisms].	4.00168e-55
NZ_CP018756.1\|WP_079223850.1\|3779993_3780275_+\|CD225/dispanin-family-protein	gnl\|CDD\|377375	pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.	2.49757e-24
NZ_CP018756.1\|WP_079223824.1\|3760505_3760799_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	8.82445e-25
NZ_CP018756.1\|WP_079223822.1\|3757365_3759588_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NZ_CP018756.1\|WP_079223860.1\|3783825_3784293_-\|polymer-forming-cytoskeletal-protein	gnl\|CDD\|224578	COG1664, CcmA, Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane].	9.69123e-28
NZ_CP018756.1\|WP_079223852.1\|3780322_3780748_+\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	2.19578e-14
NZ_CP018756.1\|WP_079223859.1\|3783401_3783794_-\|iron-sulfur-cluster-insertion-protein-ErpA	gnl\|CDD\|184186	PRK13623, PRK13623, iron-sulfur cluster insertion protein ErpA; Provisional.	5.98362e-78
NZ_CP018756.1\|WP_079223833.1\|3772062_3774120_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	4.80549e-83
NZ_CP018756.1\|WP_079223828.1\|3764105_3765347_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|183194	PRK11556, PRK11556, MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit.	4.72596e-101
NZ_CP018756.1\|WP_079223839.1\|3777600_3779490_+\|MFS-transporter	gnl\|CDD\|235865	PRK06814, PRK06814, acyl-[ACP]--phospholipid O-acyltransferase.	2.21214e-158
NZ_CP018756.1\|WP_079223823.1\|3759936_3760446_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000215789

>NZ_CP018756.1|WP_079223835.1|3774264_3776445_+|TIGR01666-family-membrane-protein
MSTRESRFSRLWAHEKASYGLRVFIALTTALGVCWHLDALPALPGVFLGIIASAIAETDDNWWGRTKAVLLSLLCFCIAAASVIWLFPLPWVFIGALALSTFCLTLLGALGERYASIAQATVTLAIYTMIGLEQHGGAGDLPRAMEAASHLLIGAVWYGLLSILWTALFANRPVRERVARLYVELGRYLQLKATLFEPVREADLQRRQLDLAEQNRRVVGALNEAKAAILARFGRSGRPGVNSGLYLRLYYMAQDFHERASSSHYPYGALVDAFFHSDVLYRCQRLLDLQGQACARLGEAIRLRRPFVYGESNQQAGRDLADALAYLRDQQRPQWQRLLGSLDLLVHNLRSIERRLLDAERSEASLDNVDTRLRDSNPHTLREMGVRIRQQLTPGSVLFRHGLRMAVALVAGFLAIRLFDAQHGSWVLLTIVFVCRPNFGATRQRLAQRVVGTLAGLVLTWALLQLFPQLHVQLLIALLSALLFFYNRTDRYLVASAAITVMALTCFNLIGDGFVLIVPRMVDTVLGCAIAAAAAFLILPDWQGRQLHLVLARVLDTASRYLDSVLGQYRSGMRDDLAYRIARRDMHNADAALSTALSNMLREPGHVRRNLDAGFHFLALSNTLLGHLSALGAHRDQVDSYAGDPLALAAGDRVRKALQQLATALTARQPVSEEDNDADRAVAAELEQIEEAMPPKLQLIRTQMALVLRLLPKVRAAANQAVTTLT
>NZ_CP018756.1|WP_079223833.1|3772062_3774120_+|TonB-dependent-receptor
MLPTRSPRLAVLAIALSAACAAHAEAPADTRSATDLDAIKVTAERTHTEAGALGDRALRDTPFAITAVGREQIEQRQVVSLGEVFLFDPSVTTQVSAYASGWSSPIRNRGIDLNFDSYRVNGLQVSSWGTEWPLEVMEQVDLLKGPGGFLYGFGAPGGIVNYITKKPTDTTTFSAQLGWREQGIASGGVDVGGRFGNEQMFGYRLNAYQEKGETFNGGHVDRKVGALSLDARLSDALTWTFDGVFQSRDLSEESPQYYFIGLTSLPRPIAGDVDNSVPGTYYDTRSSLLSTALNWQINSDWKASLSYGVTTSWNDVNKIFAYIDDVNGDYDVNVYELGGKSEWKLAQALVQGSFRTGPLQHQLVAGVSHQTGLGWDRPYEWSNIGRANLYQRSAIRHDAVGSRVLSRGDETVQQAVFASDTIDVGGGWSVLAGWRYNDFETKGSYHTYPVTPTYAVMYKPSDAVTLYASYIESLEAGSRVGNTYINAGDVLDPTISKQYEIGAKVEAPRWNANMAAFRLERGANIDLLTNAGKFLVQDGITLYEGVEASADLHLSDALTVGGGVTWLDPTYDKLSPASASQEGNRTAGAARWSGVVHANYQLPWVDGLEAYAAVRYYGDVWYDADNTLKLPDYTLVNAGVGYRLLASGHPVTLRASVENLGNRRYWSNAGVGLPRTFAVSVRWEM
>NZ_CP018756.1|WP_079223831.1|3768686_3771809_+|efflux-RND-transporter-permease-subunit
MNLSGPFIRRPIGTALLAIGLFMIGLICYLRLGVSALPNIQIPVIFVHASQAGADAATMASTVTAPLERHLGQLPGIDRMRSSSSEGSSLVFMIFQTDRDIDSAALDVQTAINSAQADLPSGLGSPMYQKANPNDDPVIAIALTSQTQSADELYNVADSLLAQRIRQISGVASVDIAGASTPAVRVDVNLRLMNALGLTADDLRNAVRAANVTSPTGFLSDGNTTTAIIANDSVARAADFAELVVKTQGDGRVIRLKDIANVYDGQQDAYQAAWFNHKPAVVMYVFTRAGANIVETVDRVKAQIPALRDYLQPGTTMTPYFDRTPTIRSSLHEVQITLLISLAMVVLTMALFLRRLAPTLIAAVTVPLSLAGAALVMYALGFTLNNLSLLALVIAIGFVVDDAIVVIENIMRHLDEGMPRLQAAFTGAREIGFTIVSITASLVAVFIPLLFASGMMGAFFREFTVTLVAAIVVSMIVSLTLTPALCSRFLSAHDHTAAPSRFGRWLDAGHDRMLRIYTVFLDFSLRHALLLSLTPLILIGVTIFLFGAVKKGAFPPQDTGLIWGRANSSATVSFEDMVARQRRITDMLMADPAVKTVGVRLGSGRQGSSAQFNVELKSRKEGRRETTAHALARLSAKADRYPDLQLRLRAIQDLPSNDGGGNSQGAQYRISLQGNDLAALQEWLPKLQAALKKNPKLRDVGTDVDNAGLRQNIEIDRAKAARLGISVGAIDGALYGAFGQRQISTIYSDINQYSVVVNALPSQTATPAALDEVYVKARSGEMVPITAVARQAPGLAPSQITHENQYTTMDLSYNLAPGVSAGEAKAIIDATVAGMRMPGDIRLADDAGFGFNSDPSDMLILVMAAILTVYLVLGMLYESLIHPVTILSTLPAAGVGALLALFGTNTELSVISMIALVLLIGIVKKNAIMMIDFALVAQREHGLAPREAAREASIVRFRPIMMTTMVAILAAVPLAIGLGEGSELRRPLGIAMIGGLLFSQSLTLLSTPALYVIFSCLAERWRARRARKREAKLLKRAQRA
>NZ_CP018756.1|WP_079223830.1|3765421_3768655_+|efflux-RND-transporter-permease-subunit
MGFSTIFIRRPIATSLLMAGLLLLGILGYRKLPVSALPEIDAPSLVVTTQYPGANATTMASLVTTPLERQFGQISGLELMTSDSSAGLSTIILQFSMDRDIDIAAQDVQAAIRQATLPSSLPYQPVYNRVNPADAAIVTLKLTSDTRPLRDVNNYADSILAQRLSQVQGVGLVSIAGNVRPAVRIQVNPAQLSNMGLTMEELRSALTQANVNAPKGSLNGKTQSYSIGTNDQLASAAEYRDTIISYKNGRPVRLSDVADVIDGVENDQLAAWADGKPAVLLEVRRQPGANIVQTVERIRAILPQLQGVLPADVHLEIFNDRTETIRASVHEVQFTLILTIGLVVAVIFVFLRRFWATIIPSVAVPLSLAGTFAVMAFTGMSLDNLSLMALVVATGFVVDDAIVMIENIVRYIEQGKSGKEAAEIGARQIGFTVLSLTVSLVAVFLPLLLMPGVTGRLFHEFAWVLSIAVVLSMLISLTLTPMMCAYLLKPDALPEGEDAHERAAAAGKQNLWTRTVGLYERSLDWVLGHQRLTLAVAGAALVLTVLLYVLIPKGLLPEQDTGLITGVVQADQNIAFPQMEQRTRQVAEALRQDPDVTGVSAFIGAGSMNPTLNQGQLSIVLKERGERDGLDEILPRLQKAVAGIPGVALYLKPVQDVTLDTRVAATEYQYSLSDVDSATVATQATRLTEALRKRPELADVDNNLSNQGRALELNIDRDKASVLGVPMQTIDDTLYDAFGQRQISTIFTELNQYRVVLEVAPEFRTSTALMEQLAVASNGAGALTGTNATSFGQVTSSNSSTATGIGAQNTGITVGAGNIIPLSALAEGKVTSAPLVVSHQQQLPAVTVSFNIAPGYSLSDAVKAIQETKDSLDMPAHLHAEFIGKAAEFTGSQTDVVWLLLASLVVIYIVLGVLYESYIHPITIISTLPPAGVGALLALMVCGLSLSVDGIVGIVLLIGIVKKNGIMMVDFAIEARRAGANAHEAIRRACLLRFRPIMMTTAAAMLGALPLALGTGIGSELRRPLGIAIVGGLLLSQLVTLYTTPVIYLYMERFSEWLARRREQRALRDGTLQEPQA
>NZ_CP018756.1|WP_079223828.1|3764105_3765347_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MSRVWKIVLLVVAVLVLAVVGVRVLGGGKDKAGGQAAGARQGGEDPDAGPVPVTVVDATRQDVPVYASALGTVTAMNTVTVSPQVGGQLMSLNFREGQEVKQGDLLAQIDPRSAQASYDQAVAAKRQNEALLATARSNYQRSNAPEYRQFVAKTDLDTQRNQVSQYESAVAANEASARAAQVQLQYTRITAPISGIAGIRAVDAGNVVSAGTALVTLTQIHPIHVLFNLPERQLGDVRQAQNAGAVPVAALDRADSHVLSGDGKLDVVDNLISADSGTFKARAIFDNTDNGLWPGQFVNVRMQLRTIGGGVVIPTQAVLRGPDGEYVYVVQGDNTVKMQTVRSGVEVGDSQVQIAEGLKGGERVVSEGQFRLKPGSKVTALKPGETPAAPTEAELKAAEQKSGGSGRRGGGPR
>NZ_CP018756.1|WP_079225399.1|3762600_3763920_-|amidohydrolase
MRRSLLLSALLLALPALAHAQQAERPEVTAAAQRLQAQVVEWRRDFHQHPELSNREERTSAEVAKRLRAMGLKPKTGIAHHGVVAIIEGGKPGPKIALRADMDALPVTEQTGLPFASKATAQYRGQTVGVMHACGHDAHTATLLGVAQALVAMKKDLPGQVMLIFQPSEEGAPPPEEGGAALMLKEGLFADFKPEAVFGLHVFSSVQAGQIAVRGGPLMAASDRFGIKVVGRQTHGSAPWNGVDPIVATADLIGTAQTIVSRRANLSKQPAVLTFGAINGGIRYNIIPDEVEMVGTIRTFDEGMRQQIFADLRNVAEHTAAAHGAKAVTDIYESEGNPATVNDPALTAKMLPSLQAVVGKDNVYEPPLQMGAEDFSLYAKEVPGMFFFVGSTSVGIDPATAPANHSPKFLLDEKALDVGFRALMQVSLDYLNGAATPAG
>NZ_CP018756.1|WP_079223826.1|3761038_3761857_-|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MNTPQDSSLGREVSYPSQYDPGLLFPIPRIGARTEIGLDDAALPFVGHDRWHAFELSWLDPRGKPQVAVATVQVPCTSPRLIESKSFKLYLNSLNSTRMESADALRERLVADLSACAGAPVQVQFGLPQLVESPLGESIDGLDVEIDCYGPPQADYLAADAGQVVEETLVSALLKSNCPVTGQPDWATVSLRYRGPKIDRAGLLRYLVSYREHAEFHEQCVERIFSEVSTRCQPQWLEVEARYTRRGGLDINPWRASHGIAGPAATVRELRQ
>NZ_CP018756.1|WP_079223824.1|3760505_3760799_-|LysM-peptidoglycan-binding-domain-containing-protein
MSTEKKADFSGVTASVDSTAELVPKADFSGVTSSVDSTADVVSVGTYTVQKGDSLSKIAKQHLGDANAWKKIFEANRDVLDDPDKIFPGQTLKLPPK
>NZ_CP018756.1|WP_079223823.1|3759936_3760446_-|hypothetical-protein
MIKTNPLHAALIAALLGSVALVGCKKNEESTDSNAAPAATTPAEPAPAPMTGAPPPMAEAATVAVSAVTVGKTAAADKSVAPAALFAPKDDVIVSVRTDAAANNVTVGAKLTFQDGQVAGEQNATLNASGAETTNITFKNANGWPAGKYRAEVMVDGKAAGTPQEFEVK
>NZ_CP018756.1|WP_079223822.1|3757365_3759588_-|NADP-dependent-isocitrate-dehydrogenase
MSKILYTLTDEAPFLATQSLLPIVDAYTATAGIVVETRDISLSGRILSLFPELLSDAQKVSDDLAELGQLATTPDANIIKLPNISASVPQLKAAIKELQDQGYPLPDYPETPADDQQRDYKARYDKVKGSAVNPVLREGNSDRRAPLSVKNYARKHPHRMGAWAADSKSHVAHMAAGDFYGSEKSATVANAGSLKITFQGKDGNAVVLKEKTAVKAGEIVDAAVMSRKALAAFIGEQIADAKAQGVLFSLHLKATMMKVSDPIMFGVAVNEFYKDVLAKHADVLKQAGFDANNGIGDLAARLPSLPEATRAAIESDLAAEYAQRPGVAMVNSDKGITNLHVPSDVIVDASMPAMIRDSGKMWNAEGKLQDTKAVIPDRCYAGVYQAVIDDCKANGAFNPATMGSVPNVGLMAQKAEEYGSHDKTFQIAADGVVKVTDEAGTVVFEHAVEAGDIWRMCQTKDAPIQDWVKLAVERARLSSTPAVFWLDAARAHDAQVIAKVEQYLKDHDTNGLDIRILPPVEATAFSLDRIRKGEDTISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGLFETGAGGSAPKHVQQFVEEDYLRWDSLGEFLALAASLEHLGNRYDNAAARVLAKALDEANGQFLDNDKSPSRKLGGIDNRGSHFYIALYWAQALAAQDEDAALKARFAPLAKALTDNEQKIVDELAAVQGKAVDIGGYYRPDVAKASKAMRPSATFNAALEQLRG
>NZ_CP018756.1|WP_079223837.1|3776682_3777477_+|SDR-family-oxidoreductase
MKIELGGRTALVTASTAGIGLAIAEGLAAAGATVVINGRSADSTERARQRLLAAVPGAEVIGVAADLSDAAGVDTLLAGLPKIDILVNNAGIFGPQDFFDTDDATWERYWQTNVMSGVRLARALLPAMVDAGWGRVLFISSESARNIPADMIHYGVSKTAQLSLSRGLAKRVAGSGVTVNAVLPGPTLSDGFAAMFEEERARSGKPLEQIGREFVMAHRPASVIQRAATVEEVANMVVYLASAQASATSGAALRVDGGVVDDIV
>NZ_CP018756.1|WP_079223839.1|3777600_3779490_+|MFS-transporter
MSGHSQFALLRQRRFLPFFIVQALGAFNDNVYRQAIIGLLFYLGVSDEQRSLYTTLAPAIFILPYFLFSALAGQIADKLEKSRLIVITTTMEIVIMSLAAIGFITENLPFLLVALFCTGMQSTLFGPVKYSVLPSVLKPEELTGGNGLVEMGTSISILSGMIIGGSVFLLAGSHGPIVAATAVIALAICGNLAARMIPRVDAGDPDLKINWNPLPESLVVLRMARQQKAVRNAILGVSWFWFVGTVLTSQLPNYALVNLGGEPKLYLFALALFSVGTGVGSLLCEKLSARTVEIGLVPLGAFGMTAFLLDLYFARTGEATVQNLGVLAFLQQPGSVRIVIDLVGIGLFTGVFVVPLFALIQSRTPKAQMSRVFAALNIQNSGFIVAAALLSLAAHQLLHWSIPQQFLALAIANVIVAIYIFTIVPEFLMRFLSWLMVRSLYRLRPHGIEANVPDEGAALLVCNHVSYMDALILSATIPRPVRFVMYYKIFNIPVMRWIFRTAKAIPIAGAREDPALMQRAFDEIDAALAEGELVCIFPEGALTKDGSMAPFKSGVEKILERRPVPVVPMALRGMWSSMWSRRDTRLGRTRVPRRFRATVQVVAAAAVDGHSADAPALEAQVRALRGDHA
>NZ_CP018756.1|WP_079223848.1|3779672_3779960_+|CD225/dispanin-family-protein
MNQPPPPSRPVYIPNHLVWAILTTLFCCLPLGVVSIVYASQVDGRRAAGDLAGAYAASRKAGWWAAASAVALPVLLLLWFGLFGGLAVLGALSDH
>NZ_CP018756.1|WP_079223850.1|3779993_3780275_+|CD225/dispanin-family-protein
MNTATPQIPNHLVWAILSTLFCCLPAGIVSIVYAAQVNGKLAAGDIAGAQESSEKAKKWAIWSAIAALVVGVLYFILIMAIGGMGALSGGSSY
>NZ_CP018756.1|WP_079223852.1|3780322_3780748_+|DUF2752-domain-containing-protein
MPPPPVPSRLGRWSPLLAASGLAAGAAVVLRHVNPYVPGNPLPSCPLYALTGFYCPGCGSTRCLYSLVHFDLPGAMAMNPLLVISLPFLFLMLLHMAGVRMKALDPLMRLLANPKFWLWVLPGYALLRNLPWAPFTALAPV
>NZ_CP018756.1|WP_152027133.1|3780878_3781319_+|hypothetical-protein
MTDRRDELTAAMKAAGCTDPRSWVNSELGEDLPQFARFLMLRDVHTLADDVDSALSEALFDRPELEQTLATLRGAVDPQALHALLHAYGKALGNSFVMALDEGPAMREDGMPGWLLMETNANDEPTGRLVQGLHEDYLDFDDRYTP
>NZ_CP018756.1|WP_079223855.1|3781357_3782245_-|regulatory-signaling-modulator-protein-AmpE
MFTTLVAVLVALALGHVAPAAAASLRRFDGFRRWLGWLDGHGGRAWQGPAGVALAIVPPLLLMALLAWLLRGVLFGLPGLLLGVAVLAWCWGPRDLDRDIEAIIDADDAAGRQAAVRHLQAAGGSLREDVPSLVEATVLNALRRWFAVLFWFLLLGPVGALAYRLLALMAESPMRARVPVEPLALAQRLLAWIEWPVAQLMAFSMALVGNFDTAWKAWRQAHGERLAGGIGFLGAVARASVNAELREEAHDYTEAGLLPVWQRLPDLRDAMSLVWRMLLLWLAVLALLVIAGWVT
>NZ_CP018756.1|WP_079223857.1|3782389_3783295_-|NAD(+)-diphosphatase
MPNTPSPLSGFAFVAEPLERADALRDDADALARLWPDARILVLDHDGTAFTGEDDQPVALTGADIGGGPGAAIFLGLRAGQAWFSVEATNVTQTAPRRLDLRQAALLWSVADATAFSYARGMSYWHSRTRFCGVCGGAVAFARGGFVGRCAQCSTEHYPRVDPAVIVAVENQGRLLLGRQSNWAPRRYSVLAGFVEPGETFEQTVVREVHEESKVRVTSCQYLGSQPWPFPGALMVGFRAQAQDDVPTVNGELEDARWFTAEEVGAALARDVEDDGEGIRLSPPISISRGLIEHWYRQQQG
>NZ_CP018756.1|WP_079223859.1|3783401_3783794_-|iron-sulfur-cluster-insertion-protein-ErpA
MSTLVSLPGATPAAAPDYQSLERPLNFTESAAAKVKELIQDEGNPDLSLRVYIEGGGCSGFQYGFEFDENRAEDDLAVQTSGVTLLVDPLSLQYLMGAEVDYTESLTGAQFVIRNPNAKTTCGCGSSFSM
>NZ_CP018756.1|WP_079223860.1|3783825_3784293_-|polymer-forming-cytoskeletal-protein
MFGNSKSSRDGQLVVDALIGNQVVIRGDVEFSGGLYVEGRIHGKVIAQEGASGATLTVAEHGVIEGEIRAQVVVISGRLDGDVHASEKVELTPSARVNGNVHYQVVEMNAGAQLNGRLIHASSPVAALPAPEGEGEATEGKGGTAARRKLAEAMA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP018756_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_26

3856489-3856580

Orphan

Consensus_repeat	Method
CACCCGAAATGCCCGCGCTGCGCGCGGTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_26

>merge|NZ_CP018756|26|3856489-3856580|CRISPRCasFinder
CACCCGAAATGCCCGCGCTGCGCGCGGTAGAGTCGACCGTTGGTCGACTGCCCTTCCATCCGCACCCGAAATGCCCGCGCTGCGCGCGGTAG

>NZ_CP018756|26|25|3856489-3856580|CRISPRCasFinder
CACCCGAAATGCCCGCGCTGCGCGCGGTAG	AGTCGACCGTTGGTCGACTGCCCTTCCATCCG
CACCCGAAATGCCCGCGCTGCGCGCGGTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079223973.1\|3854636_3855608_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176
NZ_CP018756.1\|WP_079223963.1\|3848668_3849994_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|182754
NZ_CP018756.1\|WP_079223965.1\|3850065_3850386_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223961.1\|3848012_3848672_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP018756.1\|WP_079223982.1\|3858494_3860567_-\|peptidase-domain-containing-ABC-transporter	unknown	unknown	gnl\|CDD\|225183
NZ_CP018756.1\|WP_079223978.1\|3857100_3857355_+\|accessory-factor-UbiK-family-protein	unknown	unknown	gnl\|CDD\|225508
NZ_CP018756.1\|WP_161490393.1\|3864587_3865004_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223984.1\|3860588_3861824_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NZ_CP018756.1\|WP_079225415.1\|3847719_3848013_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|225753
NZ_CP018756.1\|WP_079223967.1\|3850429_3852319_-\|arginine-decarboxylase	unknown	unknown	gnl\|CDD\|235427
NZ_CP018756.1\|WP_152027137.1\|3863664_3864561_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223960.1\|3847136_3847571_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|379323
NZ_CP018756.1\|WP_079223976.1\|3856631_3856970_-\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|366157
NZ_CP018756.1\|WP_152027136.1\|3863179_3863365_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223975.1\|3855799_3856456_+\|kinase	unknown	unknown	gnl\|CDD\|274749
NZ_CP018756.1\|WP_079223991.1\|3865110_3865953_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079223969.1\|3852510_3853365_+\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|234843
NZ_CP018756.1\|WP_079223980.1\|3857425_3858475_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275256
NZ_CP018756.1\|WP_174208738.1\|3853506_3854412_-\|aspartyl/asparaginyl-beta-hydroxylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|380241
NZ_CP018756.1\|WP_161490392.1\|3861820_3863113_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079223973.1\|3854636_3855608_+\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	4.16401e-28
NZ_CP018756.1\|WP_079223963.1\|3848668_3849994_+\|ATP-binding-protein	gnl\|CDD\|182754	PRK10815, PRK10815, two-component system sensor histidine kinase PhoQ.	1.76336e-34
NZ_CP018756.1\|WP_079223961.1\|3848012_3848672_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.08947e-72
NZ_CP018756.1\|WP_079223982.1\|3858494_3860567_-\|peptidase-domain-containing-ABC-transporter	gnl\|CDD\|225183	COG2274, SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms].	1.74165e-148
NZ_CP018756.1\|WP_079223978.1\|3857100_3857355_+\|accessory-factor-UbiK-family-protein	gnl\|CDD\|225508	COG2960, COG2960, Uncharacterized protein conserved in bacteria [Function unknown].	3.15206e-22
NZ_CP018756.1\|WP_079223984.1\|3860588_3861824_-\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	7.59531e-25
NZ_CP018756.1\|WP_079225415.1\|3847719_3848013_+\|PepSY-domain-containing-protein	gnl\|CDD\|225753	COG3212, COG3212, Predicted membrane protein [Function unknown].	4.01528e-10
NZ_CP018756.1\|WP_079223967.1\|3850429_3852319_-\|arginine-decarboxylase	gnl\|CDD\|235427	PRK05354, PRK05354, biosynthetic arginine decarboxylase.	0
NZ_CP018756.1\|WP_079223960.1\|3847136_3847571_-\|PepSY-domain-containing-protein	gnl\|CDD\|379323	pfam13670, PepSY_2, Peptidase propeptide and YPEB domain. This region is likely to have a protease inhibitory function (personal obs:C Yeats). The name is derived from Peptidase & Bacillus subtilis YPEB.	3.1253e-10
NZ_CP018756.1\|WP_079223976.1\|3856631_3856970_-\|P-II-family-nitrogen-regulator	gnl\|CDD\|366157	pfam00543, P-II, Nitrogen regulatory protein P-II. P-II modulates the activity of glutamine synthetase.	1.29416e-54
NZ_CP018756.1\|WP_079223975.1\|3855799_3856456_+\|kinase	gnl\|CDD\|274749	TIGR03724, Probable_serine/threonine-protein_kinase, Kae1-associated kinase Bud32. Members of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine. [Unknown function, General].	3.49247e-14
NZ_CP018756.1\|WP_079223969.1\|3852510_3853365_+\|polyamine-aminopropyltransferase	gnl\|CDD\|234843	PRK00811, PRK00811, polyamine aminopropyltransferase.	8.38816e-147
NZ_CP018756.1\|WP_079223980.1\|3857425_3858475_-\|radical-SAM-protein	gnl\|CDD\|275256	TIGR04463, Radical_SAM_domain_protein, radical SAM/SPASM domain protein maturase. Members of this family are probable protein/peptide-modifying radical SAM/SPASM domain proteins. The majority of members of this family seem to target Cys-rich repetitive regions of large proteins rather than of bacteriocin-sized small precursors. This arrangement suggests the modification target may be multifunctional, with the C-terminal domain behaving like a bacteriocin but other parts of the same precursor serving an immunity function, as occurs for the halocin C8 precursor.	1.61382e-28
NZ_CP018756.1\|WP_174208738.1\|3853506_3854412_-\|aspartyl/asparaginyl-beta-hydroxylase-domain-containing-protein	gnl\|CDD\|380241	NF033391, lipid_A_LpxO, lipid A hydroxylase LpxO. Members of this family are LpxO, an enzyme that modifies one of the lipid chains in lipid A by hydroxylation, with resulting changes in resistance to the host immune response and to the antibiotic colistin. This family, as built, includes LpxO1 from Pseudomonas aeruginosa, but not its paralog LpxO2.	0
NZ_CP018756.1\|WP_161490392.1\|3861820_3863113_-\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	4.46725e-25

>NZ_CP018756.1|WP_079223975.1|3855799_3856456_+|kinase
MTSSVSPSPSCGDDAVAPLLLKRGDRFLAPDVYRTCLDGRPAVVKDYSRYRGTPVSLIARLMVRREARILQRLGGWKHAPALLGTLGGLALGMEFIPGQTLSTAQAVGNEVFDQLQHALSRLHAAGITHNDLHGTNVVVSGGVPVLLDFTSAWRAPRWLRRNPLSRQMRRSDMKNLLKIRQRVTGQAPSAAQAALVADPGWVAAVRQGWKRFYKWAKR
>NZ_CP018756.1|WP_079223973.1|3854636_3855608_+|alpha/beta-hydrolase
MPACDHAPYPALSARYAAFFPGQPAATPRSEAFQWAGGTLRLDRHGPADAGATVVLVHGAGGYGRMFAPRAAGLAAAGHEVVAPDLPGYGLSPAAWQAIDYGTWKQALLALIEAEYRRRPRPIVLLGASIGGYLAYLVAAESPWVQGLVATTLADPRDPDVQAALVRRPWMRALLPTLRPLSRLTRGLRVPVRWFTHMQRMSRDPALTALVCADPLGGGNRVPLGLLASLFDTAPALEPEQFQRCPVLMLHPACDDWTPVAISDRFFQRLAAPKQRVLLDECGHFPIEQPGLDQLRDALLPFVQRIAGQFSGKPLIEKARSAK
>NZ_CP018756.1|WP_174208738.1|3853506_3854412_-|aspartyl/asparaginyl-beta-hydroxylase-domain-containing-protein
MIKIVLAALFVACVLYIHYRGKVRARWSRQLLDHSSFMAPINVIMYLFSKVPTTPFLDPGKELPQLEPLRQNWQVIRDEALALRDAQKIAASSSYNDAGFNSFFRRGWKRFYLKWYGPSHPSAKAMCPKTVALIESIPDVRAAMFAQLPPGSELRPHRDPFAGSLRLHLGLSTPNDDGCYIVVDGVKKSWRDGEWMMFDETYIHHAHNETDQDRVILFCDIARPLRFGLPGLFNRAVASTLLAGGASPNLPGDPTGGVNKAFGGVYKVRLKAKALRERSVVAYQVIKWGLVVAVIAGIWAI
>NZ_CP018756.1|WP_079223969.1|3852510_3853365_+|polyamine-aminopropyltransferase
MTDSSNWYIEHFERTGSAIGFRITGKLDEVQSPFQKIEIFQTTDWGNLMTIDGAIMLTSKDNFFYHEMISHPVLFTHAAPKRVVIIGGGDCGTLREVLKHKGVESVTQCDIDEQVTVMARKHFPELCDSNDDARAELLFDDGVAYMANCPAGSVDVVIVDSTDPVGPGEGLFNKAFYESCFKALKDDGILVQQSESPLMQLELINEMRTEMGKAGFGSFKTLPFPQPCYPTGWWSVTMARKGESGFDFRQADSAAKTFNTLYYTAALHTGVLVTPPFVASALKG
>NZ_CP018756.1|WP_079223967.1|3850429_3852319_-|arginine-decarboxylase
MTDWSLDQARKTYSIPHWADGYFDVDQAGHMVVRPTGADGPVVSLPKVVDAARAGGAKLPLLVRFPDILGQRLGKLQAAFAQAQQDWEYPGGYTAVYPIKVNQHRGVAGTLASHHGEGFGLEAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRKLGLQTFIVIEKPSELKLVLEESKALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQLLDLWKSLRDTEYADCLNLLHFHMGSQISNVRDIANGMREATRYFVELSQLGAKITHVDVGGGLGVDYEGTRSRSFCSINYGLNSYASNIVQPLANACEEHGLTPPRIVTECGRAMTAHHAVLIANVSEVEQAQEGRVPDQHDDEPASIRHLREIHEELDTRPAVELFQEAQHFHAEGLASYALGQIDLPQRARIDDLFYAIAHGVRARLSYDEKSHRPALDELNERLVDKYFVNFSVFESIPDAWAIDQVFPIVPIERLNETPDRRGIIADMTCDSDGMVKTYVENESLDTSLPLHAMKHGESYRIGFFMVGAYQEILGDIHNLFGDTDAVEVVADADGYAITQQRRGDTTDVMLDYVGYKLDDLRAAYAQRVAAAELSPERAQELSQALEAGLTGYTYLSDEPLA
>NZ_CP018756.1|WP_079223965.1|3850065_3850386_-|hypothetical-protein
MSARAIFHLFLHAAVPALLAWLFWRKRFASAWLLLLLGWIIDLDHLLADPIYAPNRCSIGFHPLHTAPAIAVYAGLCVPKKTRLVGIGLMIHIALDAIDCWWMHHR
>NZ_CP018756.1|WP_079223963.1|3848668_3849994_+|ATP-binding-protein
MSARQPSLRRRLLLVAGIGLVLVSVLAGVLLGELFKRSARDRLDGELQQDMLTLLAQAEIDPDGQLRLRQEPNDARFQRVFSGAYWQIADSHGKVLLQSRSLWDQTLPATAAGPAERDLSGPMQQSLRARVQQVRLPRATQAYVALVAHDRQALDADVAAFRNRSALALGILVAAWLAVLASQVHFGLRPLRGLGQQIERIRRGEAERIDRRQLDREIAPLADELDALLDHHQRMVARARSSAEDLAHALKTPLSVLAAEAQGEGRDWRRTLHEQGARMRASIDRYLAAGLAVDHRQSSEVAPAAEALCRLMTRVHGGRRIRFQMDVPRGIAFAGAATDLEEMLGNLLDNAGKWAQGEVRLRALAQNDRLHIEVRDDGPGLDKAKLESVLQRGVRLDERVEGSGLGLAIAAEIAASHGGSLRLSNENPGLRARLELPLAAP
>NZ_CP018756.1|WP_079223961.1|3848012_3848672_+|response-regulator-transcription-factor
MRILLAEDDAALAQRLQPLLEQAGYVVQAVADGRQAEEIGQIEDLQAAIIDLGLPGLDGLSVIERWRGNGRSFPVLVLTARGRWHDKLAGFDAGADDYLTKPFQADELVLRLRALIRRSHGHASPRLQCGPLQLDVNAGRFEMDGQALALSPQEFRVLSYFIHHAGSVISRDRLGEQIFESGYDPDSNALDVLLGRVRRKLGVDLIHTVRGQGWRLAEA
>NZ_CP018756.1|WP_079225415.1|3847719_3848013_+|PepSY-domain-containing-protein
MLPFALPLLLALASPTTAAQPAKDPAQDVARRAVQQGRYVALEGVVRDALTRHPGQLLEVELDDGVYEVEILRADGVVVELDYDARNGRLLKTELDD
>NZ_CP018756.1|WP_079223960.1|3847136_3847571_-|PepSY-domain-containing-protein
MLKSLTLATVVALAFAPAVQAAPLGMAQVEKTLRKAGYTQIHEIERDDGLWEADVSRADGRFSEVYVDPKTGEIFDEHDGRTLLGTEQVLAKAQAHGLREIHSLERDGATWSLEARNARNQRVEVRLSGHDGRILHSERDSWLD
>NZ_CP018756.1|WP_079223976.1|3856631_3856970_-|P-II-family-nitrogen-regulator
MKMVMAVIKPFKLDDVREALAERGVTGITVTEVKGFGRQKGHTELYRGAEYVVDFLPKVKLEVAVTDDQVELVVEAIVKAAGTGKIGDGKVFVYDLGSVVRIRTGELDADAL
>NZ_CP018756.1|WP_079223978.1|3857100_3857355_+|accessory-factor-UbiK-family-protein
MIDLNHLDDLARRLSDLVPPGLRESREELQATFKTALQAGLAKLDLVTREEFEVQRAVLLKTREKLDALEATVREIEGRDSTQA
>NZ_CP018756.1|WP_079223980.1|3857425_3858475_-|radical-SAM-protein
MENFQERLNRRLELTIMPTEKCNFRCVYCYEDFEIGRMRAPTIAGIKALVRRRVEQHGLKELRVEWFGGEPLLAKGVVLELSRDFHAHSSSGALEMLDCSMTTNGFELTPPLFNELVALGVNFFQISLDGDSDAHDLTRRYASGAGTFHRIYENLLAMKASSFNFTVMMRLHIMPGNEESLMRLSRRLCGDFKGDARFTVFLRDISNLGGKGESLQMITHAEAVRISKLLQAHFEAEGFFVENGVEAEFESQVSVSGLSDSNPAFQSLKESGLRVSHVCYAAKPNHMLIRADGRIGKCTVALGSEGNVVGALAEDGTVALDAGKMKFWTRGFLSGDASELGCPLITRTG
>NZ_CP018756.1|WP_079223982.1|3858494_3860567_-|peptidase-domain-containing-ABC-transporter
MVLGLWNRWMLRSRDVVLQSESTECGLACLAMIAARYDRRVTLRWLRRRYPVSLRGTTVARLSEIARDLGLQHRVFAGTASALRRLDATCVILVDDCHFVVVERCGAEQFLVLDPAVGELVLSCAELEKRFSGALLRFTGGSRQCEDMPVEPSPWSALTSQMRPRRLRYLPILLLALVAELLTVAAPLYIQSAVDGLGGAGLFSAEGLLLIFAFIAIARVWATSIRGLLTVDLGASIVGGLSNSVFGRVLELPPSYFLRRHAADVISRLGSVHEVQELASSRIVECAVDALALFILLAACCTYSLPLAGMAASGAALCMAVRVSMSGRVGVACNVLANRLASQDREVIETVRAAQTVKLNGMERLRGDRFRRGNASLIRASISLQRMAIFSQSGSDVILGLLRVLVVYAGVLAVDSGALSVGALVAVTIYVEMICQRASALVPKVMDVKMARVHLQRISEVLSEPAEECADWAGAGGRGPAPSVVCRGIHFRYSVDDPWVLKDVSLTIRPGEMVAIVGPSGVGKSTLLSILAGLVAPTAGVLEVDGCDVKACHLPLLRRQIGTVLQQDTLLSGTVLENITLGEVADMPRVWRCLAAAGLDNFASSQPMALATQVGDEGRLLSGGQQKRLLLARALYRAPRVLVLDETLSQLDYEAEQQIMSVLLGLQMTRIIVTHRVSTLPEGVRVIRVG
>NZ_CP018756.1|WP_079223984.1|3860588_3861824_-|ABC-transporter-permease
MTVVHAMVTTLKTVSKHLTVVGLMVLQISVSMAVLANISTIVLEASERIDAESGLSEARIAVVQNIGVIGFEDAATSSGAGLRALRDVPGISAAAIGPVPFAVERGAVRLEKSNRDASGHPYIYFGSEQLASVLGTSVVQGVALDSLQAPSVEDVLEPNSTLAVPAVVTRSLAKRLFPAGDALGKMIHTEVWGSYPLTLRVVGITADFRSASSGDASDYEAVISEVKIDAQSIGGLYAVRRNVPFDLEAKRVVTRALSSSMPGFVQEPVRSVAELRTAHFAKDASRSSMLLAVVFVVTASSALGVFGMSHYWVSARHRSIAIRRALGASRREVVALFAVESAVVAGLGVILGAGLAVAANRLLALQLEIAAVSAASVALGAGLTLLSCQIAALIPALGAAKVDPALAFRQR
>NZ_CP018756.1|WP_161490392.1|3861820_3863113_-|ABC-transporter-permease
MRYALELALSGIHRSKLLSVLIVLAVATGISAFATMLLIRIGLGGDPAPSISQSLYHVELDLRDDAARSSSARPLSVLSLHDVQEITRLTGVPSVATSSSWLPYRPMGTDLPLGMIAVRGFTSGAHSLLDLKLLSGAFWRSDDDQNGARVAVISRSLSRELFGSESAVGRQIELATRSFAIVGVVEDWNPIPRFHDLRGGAYAESERLYIPLAAWRALPKDYGMGAMSCRDGVPEDPESASCAWLQLWVQLNDTHALGAFSSALHRYGLAQVDSGRATDVFSRVAPLKEWLAINDVLPDEVSTQLWFAAGVLVICLVNAAGLFLAGVVGRSREIAIRRSLGATRGDIVRQLAVHSAVLGAAGGLVSIPMVLLGFRVVQGLSSAYASHLSIAWWYVALCPLVAAMSALLSASIPLWRASQRFVSLRMGEVP
>NZ_CP018756.1|WP_152027136.1|3863179_3863365_-|hypothetical-protein
MKEIRQTAETNHPFVYDENGLCEVRDPRALEMLGAGGVQASGAVCKVNSGNCVSGCACKSS
>NZ_CP018756.1|WP_152027137.1|3863664_3864561_+|hypothetical-protein
MIDLCPTASSTTHIAFLRDSFGVPTPGNGRPSIPTGVTIMLRYSALLFALALPGTTLAADGLDPAATERCVAWMKERPSSAPAEVRTVAPDTLCADFTSSLTSDSRDAFLTQMSAIPAGVTPQVIVRSMGGDVELGMDMGDAILNRKASVHAYQLCVSSCANYLFLAAPTRHVMPDSVVLFHGGMVPRMTKLPDVTAEGRQRLQASIERQDGFLHRAAVYPPLFEWMDRLNEPDANLMHHCPADRTITLIQLSDAVLAGIGAPVASNEGPRSQEAVDALVARYGPAMAVCYWDQPVKR
>NZ_CP018756.1|WP_161490393.1|3864587_3865004_-|hypothetical-protein
MLLGLAALLASCATPFQRPPAEKFRLDIVDNADARRFEITLTSLDTRAMCVSAEDWPDDVGGFVVSQESTYLQIDAQALVPTSSFSSVYCPGGCGEHRIAPNATLRRTINYATFGDAATIAASPSKVLHFVATPYYCR
>NZ_CP018756.1|WP_079223991.1|3865110_3865953_-|hypothetical-protein
MRVKTIAMGWVLVGLSGAGNFAAATTTINEPARDTTAELLQGVPPAEQASSASAYRYVRHCLARRQFESFLRSDGIDPDATSSLRVRAAGMQEPLRTRFLENVRMLDARRAECAPWQQSVAPDKAALQVYLLALDNAAAGDARAAACFVALPWAEPAQGTPDHARFAGAYTAQARMLIDAGIASGSWLMVRAAAGRLDAHPHATMTLPLEPALAYRISRLMQMGIEDPALSGTFAADARRYASSLSPAVLEVLEKDVQSQFSSVFAGRGGDLDSFTRLCD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP018756_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_27

4511063-4511162

Orphan

Consensus_repeat	Method
CGTGCCGACCAACGGTCGGCACCTACCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_27

>merge|NZ_CP018756|27|4511063-4511162|CRISPRCasFinder
CGTGCCGACCAACGGTCGGCACCTACCAGTAGAGCCACGCCACGCGTGGATGCATTTCGCGCACGGCCAGAGCGTGCCGACCAACGGTCGGCACCCACCA

>NZ_CP018756|27|26|4511063-4511162|CRISPRCasFinder
CGTGCCGACCAACGGTCGGCACCTACCA	GTAGAGCCACGCCACGCGTGGATGCATTTCGCGCACGGCCAGAG
CGTGCCGACCAACGGTCGGCACCCACCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079224858.1\|4505392_4505647_+\|DUF2798-domain-containing-protein	unknown	unknown	gnl\|CDD\|378657
NZ_CP018756.1\|WP_079224877.1\|4516352_4517528_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|379770
NZ_CP018756.1\|WP_079224871.1\|4512875_4514381_+\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NZ_CP018756.1\|WP_079224873.1\|4514395_4515562_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173851
NZ_CP018756.1\|WP_079224862.1\|4506645_4507272_-\|bifunctional-nicotinamidase/pyrazinamidase	unknown	unknown	gnl\|CDD\|238493
NZ_CP018756.1\|WP_079224869.1\|4511393_4512761_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226322
NZ_CP018756.1\|WP_079224860.1\|4505707_4506559_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NZ_CP018756.1\|WP_192851854.1\|4508650_4510498_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132846
NZ_CP018756.1\|WP_079224885.1\|4520287_4521742_+\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP018756.1\|WP_079224867.1\|4510541_4510979_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079224879.1\|4517524_4518415_+\|3-hydroxyisobutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|130753
NZ_CP018756.1\|WP_079224881.1\|4518563_4518989_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP018756.1\|WP_079224875.1\|4515558_4516356_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|236373
NZ_CP018756.1\|WP_079224864.1\|4507328_4508000_-\|epoxyqueuosine-reductase-QueH	unknown	unknown	gnl\|CDD\|224551
NZ_CP018756.1\|WP_152027161.1\|4521914_4523162_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|379157
NZ_CP018756.1\|WP_079224856.1\|4504358_4505270_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP018756.1\|WP_079224883.1\|4519098_4520079_-\|cation-transporter	unknown	unknown	gnl\|CDD\|226474
NZ_CP018756.1\|WP_079224850.1\|4501749_4502172_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|239526
NZ_CP018756.1\|WP_079224854.1\|4503251_4504355_+\|NADH:flavin-oxidoreductase/NADH-oxidase	unknown	unknown	gnl\|CDD\|239242
NZ_CP018756.1\|WP_079224852.1\|4502215_4503022_+\|NAD-dependent-protein-deacetylase	unknown	unknown	gnl\|CDD\|235415

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079224858.1\|4505392_4505647_+\|DUF2798-domain-containing-protein	gnl\|CDD\|378657	pfam11391, DUF2798, Protein of unknown function (DUF2798). This family of proteins has no known function.	2.87281e-12
NZ_CP018756.1\|WP_192851854.1\|4508650_4510498_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132846	cd07207, Pat_ExoU_VipD_like, ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2. ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.	1.28295e-05
NZ_CP018756.1\|WP_079224873.1\|4514395_4515562_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173851	cd01162, IBD, Isobutyryl-CoA dehydrogenase. Isobutyryl-CoA dehydrogenase (IBD) catalyzes the alpha, beta- dehydrogenation of short branched chain acyl-CoA intermediates in valine catabolism. It is predicted to be a homotetramer.	0
NZ_CP018756.1\|WP_079224862.1\|4506645_4507272_-\|bifunctional-nicotinamidase/pyrazinamidase	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	2.51621e-92
NZ_CP018756.1\|WP_079224869.1\|4511393_4512761_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|226322	COG3800, COG3800, Predicted transcriptional regulator [General function prediction only].	7.34147e-125
NZ_CP018756.1\|WP_079224860.1\|4505707_4506559_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	0
NZ_CP018756.1\|WP_079224871.1\|4512875_4514381_+\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NZ_CP018756.1\|WP_079224885.1\|4520287_4521742_+\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.01987e-135
NZ_CP018756.1\|WP_079224877.1\|4516352_4517528_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|379770	pfam16113, ECH_2, Enoyl-CoA hydratase/isomerase. This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.	1.99606e-144
NZ_CP018756.1\|WP_079224879.1\|4517524_4518415_+\|3-hydroxyisobutyrate-dehydrogenase	gnl\|CDD\|130753	TIGR01692, 3-hydroxyisobutyrate_dehydrogenase_mitochondrial, 3-hydroxyisobutyrate dehydrogenase. 3-hydroxyisobutyrate dehydrogenase is an enzyme that catalyzes the NAD+-dependent oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde of the valine catabolism pathway. In Pseudomonas aeruginosa, 3-hydroxyisobutyrate dehydrogenase (mmsB) is co-induced with methylmalonate-semialdehyde dehydrogenase (mmsA) when grown on medium containing valine as the sole carbon source. The positive transcriptional regulator of this operon (mmsR) is located upstream of these genes and has been identified as a member of the XylS/AraC family of transcriptional regulators. 3-hydroxyisobutyrate dehydrogenase shares high sequence homology to the characterized 3-hydroxyisobutyrate dehydrogenase from rat liver with conservation of proposed NAD+ binding residues at the N-terminus (G-8,10,13,24 and D-31). This enzyme belongs to the 3-hydroxyacid dehydrogenase family, sharing a common evolutionary origin and enzymatic mechanism with 6-phosphogluconate. HIBADH exhibits sequence similarity to the NAD binding domain of 6-phosphogluconate dehydrogenase above trusted (pfam03446). [Energy metabolism, Amino acids and amines].	2.21723e-126
NZ_CP018756.1\|WP_079224881.1\|4518563_4518989_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	2.25918e-77
NZ_CP018756.1\|WP_079224875.1\|4515558_4516356_+\|enoyl-CoA-hydratase	gnl\|CDD\|236373	PRK09076, PRK09076, enoyl-CoA hydratase; Provisional.	1.09501e-170
NZ_CP018756.1\|WP_079224864.1\|4507328_4508000_-\|epoxyqueuosine-reductase-QueH	gnl\|CDD\|224551	COG1636, COG1636, Uncharacterized protein conserved in bacteria [Function unknown].	2.05359e-115
NZ_CP018756.1\|WP_152027161.1\|4521914_4523162_-\|HNH-endonuclease	gnl\|CDD\|379157	pfam13391, HNH_2, HNH endonuclease.	1.09298e-11
NZ_CP018756.1\|WP_079224856.1\|4504358_4505270_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.98179e-64
NZ_CP018756.1\|WP_079224883.1\|4519098_4520079_-\|cation-transporter	gnl\|CDD\|226474	COG3965, COG3965, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	5.53482e-103
NZ_CP018756.1\|WP_079224850.1\|4501749_4502172_+\|acyl-CoA-thioesterase	gnl\|CDD\|239526	cd03442, BFIT_BACH, Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, and brown adipose tissues. The archeal and eukaryotic members of this family have two tandem copies of the conserved hot dog fold, while most bacterial members have only one copy.	6.34278e-50
NZ_CP018756.1\|WP_079224854.1\|4503251_4504355_+\|NADH:flavin-oxidoreductase/NADH-oxidase	gnl\|CDD\|239242	cd02932, OYE_YqiM_FMN, Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing agent. The YqjM enzyme exists as a homotetramer that is assembled as a dimer of catalytically dependent dimers, while other OYE members exist only as monomers or dimers. Moreover, the protein displays a shared active site architecture where an arginine finger at the COOH terminus of one monomer extends into the active site of the adjacent monomer and is directly involved in substrate recognition. Another remarkable difference in the binding of the ligand in YqjM is represented by the contribution of the NH2-terminal tyrosine instead of a COOH-terminal tyrosine in OYE and its homologs.	0
NZ_CP018756.1\|WP_079224852.1\|4502215_4503022_+\|NAD-dependent-protein-deacetylase	gnl\|CDD\|235415	PRK05333, PRK05333, NAD-dependent protein deacetylase.	2.79663e-175

>NZ_CP018756.1|WP_079224867.1|4510541_4510979_+|hypothetical-protein
MSARQELLDLLERLDARDPDHLPVVPLAAYFEGNDFEECIAPNQWGYGRPPIAELYARLAAIAAKPEVEGVYVGLHQDWGNALEDDSEWPAAENVHVLTRADAATVEGWLQGLECDGVGEGWPYGQHIDAPVPSAGHRVLTVFWD
>NZ_CP018756.1|WP_192851854.1|4508650_4510498_+|patatin-like-phospholipase-family-protein
MKGGITSGIVYPNAVLALARDYRFKSIGGTSAGAIAAAVAAAAAYGDRRQQAGEHLADGTGYGGLSAVSAQLSRRGFIYSLFQPARGARAAYRLLVALTGGYGWPRKLLCLAVAVFEIAPLEVLVSLALLLGLGWWGGGWSGVAATLLPSLLCAYGAGVAGAALRVARVARRNLLGLCSGLGRDARKPALTEWLHQSLQELSGKPLDAPLTFADLHDAPRYAGEPESPHAISLQMITTCVSHNEPRTLPLGGAQFWFLREEFEQLFPASVVQWLVDHAGTPVDVEGRQYYHLPQGPQLPVLVATRMSLSFPLLISAVPLHEPARRERRCAPSPATPDAEHNVADSMEGLTSAGQSCGPVITAFRICWFSDGGISSNFPIHLFDAAMPRWPTFAINLVYPQHAEDVSHGTTGQQALERAVVLPTENRHGWQRHYQSIATPLAAAELGRFLFAVVATMQNWRDLLQARAPGYRDRIVHVSLQGDEGGMNLDMPQEVLSRIADKGSLAGARFCAFSFENHYWIRWRNLASAYQRYTLEVARTDDPAQQVLAYRAAYSIVANGEPVAPSYKLGSEDKRRGSQQLWAQMVEQGRTWEDLGPDLTDGAPRPLPQMKVTPIY
>NZ_CP018756.1|WP_079224864.1|4507328_4508000_-|epoxyqueuosine-reductase-QueH
MTEFQRPALSLPTDGKRLLLHSCCAPCSGEVMEAITASGIDYAIFFYNPNIHPVKEYELRKQENIRFAEQHGIAFIDCDYDTDNWFSRARGMENEPERGIRCTMCFDMRFERTALYAHEHGYDTISSSLGISRWKNMAQINDCGIRAASRYEGLQYWDYNWRKGGGASRMVEISKREQFYQQEYCGCVYSLRDANRHRRETGRERIKIGLLYYGQDAETPQGD
>NZ_CP018756.1|WP_079224862.1|4506645_4507272_-|bifunctional-nicotinamidase/pyrazinamidase
MTALPADVALLVIDLQPDFMPGGALACDQGDALVAPIAELLAQRHYRTVVATQDWHPADHASFASQHPGTRPFESILLHAQPQTLWPDHCVQGSDGAALHPGVDWTVADLILRKGTRQQVDSYSAFRENHGPEGERPPTGLAGWLHERRIREVHVCGLARDYCVLWSAQDAVKSGFRVKFLWDLTRPVTEANDSMVREALGKAGIAIV
>NZ_CP018756.1|WP_079224860.1|4505707_4506559_+|formyltetrahydrofolate-deformylase
MRPDSILTLSCPDRTGIVYRVSGLLFDHGCNILDAQQFGDEESGRFFLRVHFDRDASLPLDTVHAAMAALAADYGMDWQLHDGRRRARLLVLVSKQGHCLNDLLFRAHSGQLKVDIAAVASNHADFAPLAASYQVPFHHLPVNAETRAVQEQQIIDLVERERIDLVVLARYMQILSPTLCRALAGRAINIHHSFLPSFKGAQPYHQAHARGVKIIGATAHYVTEDLDEGPIIEQDVARVDHAMAPRELVRLGSDTESQVLARAVRRHVEHRILLNGHRTVVFR
>NZ_CP018756.1|WP_079224858.1|4505392_4505647_+|DUF2798-domain-containing-protein
MAYPRSPRWKLHARSTPFVFAFFMAGLMALLMCLVITAANAGVGSGYLARVLAAYQMAMPVAFCGVLLVRPLVVRLVALTVHPH
>NZ_CP018756.1|WP_079224856.1|4504358_4505270_-|LysR-family-transcriptional-regulator
MNLLQLIRSFTRTAETGSIAAAARQLGISATAVGQNINRLEAHLGVRLLNRSTRQLALSEAGAVYLAQVRHIEADLARAQAMVTAGDIEPSGPLRIASSSAFGRHVLAPLLPSLQQRYPQLQLELRLSDRAVQHGPEAVDASIRIGAQLEDGLVARPLARIPFVFCASPAYLEAHGTPGDPAALNGHRGLLHRFPTDGRPLRWGLLKDGQRMDAALPPSMVCDDIDALAELAAAGAGITRLAAFVAEPYLRDGRLQAVFGPASAWQPAPMEVFFCVSDRRDFTAKIRALFEHLQAGMAPAWQV
>NZ_CP018756.1|WP_079224854.1|4503251_4504355_+|NADH:flavin-oxidoreductase/NADH-oxidase
MSQLFSPMSLGPLTLPNRIVIAPMCQYSAEDGRASDWHAMHLGNLAQSGAGLLILEATAVEPRGRISWADLGLWDDGTEAALAQVLASVRRWSSMPLGIQLAHAGRKASTARPWDGGRQLPADDANGWATVAPSPVPFHATDPAPEALDEAGIAEVIAAFAASAVRAERLGFELIEIHAAHGYLLHQFLSPLSNRRTDGYGGSLPNRLRLLVEVFDAVRAAVSDKMAVGVRISATDWVDGGWDLVQSEALAQILDARGCNFLHVSSGGLDERQKISVGPGYQVPFAAAIKAKKLRMPVIAVGLITEPEQAESILRHNQADAIGLARGILYDPRWPWHAAAALGDSVVPSPQYLRCEPREARNVFRAR
>NZ_CP018756.1|WP_079224852.1|4502215_4503022_+|NAD-dependent-protein-deacetylase
MTPPLTDFIDRAQRLFVLTGAGCSTASGIPDYRDTDGQWKRTPPVTYQAFMGEAATRQRYWARSLLGWPRFGLALPNGTHQALAALEARGTLQVLLTQNVDGLHQRAGSRNVIDLHGRLDLVRCMGCERRSGREDFQQRLLDANPGWDALEAGIAPDGDADLETDFSAFVVPDCPYCGGLLKPDVVFFGENVPRERVAAVHEHLQQADAVLVVGSSLMVYSGFRFVQAAAKAGLPVAALNRGRTRADDLLQFKDERDCAEALAGFVTR
>NZ_CP018756.1|WP_079224850.1|4501749_4502172_+|acyl-CoA-thioesterase
MTPIPETVPPIEVRMAEIVFPNHTNHMGTLFGGQALAWMDKAAFLAAARYSRRTVVTARSDQVDFKLPIRIGQMVETVGRIVEVGRSSMKVEVELIAEDLHSGERKLCTRGHFVMIALGDDGQPTAVPRLPGTPAADPAS
>NZ_CP018756.1|WP_079224869.1|4511393_4512761_-|XRE-family-transcriptional-regulator
MNFQPSQRQLGLRLLRLREQRGYSQVDLARALGLSASYLNQIERNKRPLTPAVQKKLGEVLGDVSSLFDDDEPAALQEALGETLRDLGLAEVSATELRALAGNLPQVSRALLDLHRRHLALREHAAALEFQLGEPEAGSTLPAGDQVREFFNRMHNHIPELDELAERLFAEWGLSPGHVAPRLRQLLADRHGVLVEVAALQAGREKRQFDAGARRLWLPDYLEPGQQAFQMAAELALHGYLPQIDAVIARAGFQDEARIAQARIGLSNYFAGALVMPYMRFLRAAEASSYDIELLAHQFGVGFEAVCHRLSTLARRSAPGLPFFFIRVDRAGNVSKRHSATDFHFSQVGGSCPLWIVYEAFNQPGRILTQTARMPDGRRHFWLARQVSSGPVGHGQPRKTFAVALGCDLQHAERLVYSLGLDVQSPGNSVSIGPGCRVCPRVDCMQRAFAQLPGR
>NZ_CP018756.1|WP_079224871.1|4512875_4514381_+|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MTVAAPRIRMLIDGQFVESATSHWQDVINPATQDVLAQVPFATTSEVDAAVAAAKEAFKTWRKTPIGTRARIFLKYQQLIRENMSELAHILTAEQGKTLPDAEGDVFRGLEVVEHAAAIGNLQLGELANNVANGVDTYSIMQPLGVCAGITPFNFPAMIPLWMFPMAIATGNTFILKPSEQDPMVTMRLVELALEAGIPKGVLNVVHGGEEVVNAICDHPDIKAVSFVGSTRVGTHVYNRASLAGKRVQCMMGAKNHAVVLPDANKEQTLNAMVGAAFGAAGQRCMAASTLVLVGEARNWVQDLVAKAQTLKVSGGTVSGTDVGPVISCSARERVEGLIASGVEQGAKLVLDGRKPQVDGFEKGNFVGPTIFAGVTTDMRIYQEEIFGPVLVILEAETLDEAIAMVNSNPNGNGTALFTQSGAAARRFQEDIDVGQVGINVPIPVPVPLFSFTGSRASKLGDLGPYGKQVVLFYTQTKTVTARWFDDETLSHGVNTTISLK
>NZ_CP018756.1|WP_079224873.1|4514395_4515562_+|acyl-CoA-dehydrogenase-family-protein
MSHSMTTDQEEAQQAYREAARDFAQAELAPHAARWDAEGIFPREAIAKAGELGFCGLYMDPEVGGSGLSRLDAAVVIEELANVDPSTAAYISIHNMASWMVSKWGQAELRDAWGTDLSSGSKLASYCLTEPGAGSDAASLKTTAVRDGDFYVLNGSKAFISGAGATELLVVMARTGGAGAGGVSAIAVPADLPGISYGRKEEKMGWNSQPTRGITFENVRVPVSHLLGEEGGGFKLAMKGLDGGRINIAACSLGAAQGALDAARRYMGERRQFGKALADFQALQFKLADMAIELVAARQMVHSAARKLDAGASDANVWCAMAKRFATDAGFKICNEALQIHGGYGYIREYPIERLLRDSRVHQILEGTNEIMRVIVARHLLNTEEELR
>NZ_CP018756.1|WP_079224875.1|4515558_4516356_+|enoyl-CoA-hydratase
MKDWRTQEHVGLKVEADGHTAVVTLHNPPAHTWTVHSLAALRDLVGALNADRDIYALVITGDGEKFFSAGADLNQFASGDKGAAREAARRFGEAFEALSAFRGVSIAAINGYAMGGGLECALACDLRIIEDHAQVALPEATVGLLPCAGGTQNLPRLVGEGWAKRMILLGERVNAETALRIGLAEEKVGKGEAKALALEWAKKAGKQSPTSIAACKTLVQSTRTGTHASALVAEREAFVDLFDTADQVEGVTAFLEKRAAQWKNA
>NZ_CP018756.1|WP_079224877.1|4516352_4517528_+|enoyl-CoA-hydratase/isomerase-family-protein
MTADTVADEAPVLFEERVAGNGTRIGIATLNAPRTLNGFSLPMAHLLLKQLNAWADDDGIAMVVLQGAGEKAFCAGGDLHSLYKAMVAFREAGHGDIRENDYAAEFFDVEYRVDYLIHTYAKPILCWGHGIVMGGGIGLMSGASHRVVSERSKLAFPEITVGLFPDVGGSWLLPRVPGKGGLFLALTGALLNPGDAIYAGLADVHVAEDRRSAVFDALLQVAWSSDAAHNHERLDHLLQSHASDAATGPLLANAAQVDALCEGDDLSAIIDRISSLQTDDAWLQAAQKTLAAGAPGSARLAFELQRRSAGQDLASVYRLEYITALQCAARGDFAEGIRALLIDKDRNPQWNPATLAEATAAWAQTFFVSPWADAAHPLADLGTPLAERSLA
>NZ_CP018756.1|WP_079224879.1|4517524_4518415_+|3-hydroxyisobutyrate-dehydrogenase
MSRIAFIGLGNMGGPMAANLVKNGHTVRVFDLVPAAVQAAVDAGASAAPSARDTLADAEVVISMLPASRHVEGVYLGEDGILAAIPAGALVIDCSTIAPASARKVSEAAAARGLQMLDAPVSGGTAGAQAGTLTFIVGGEEDALERARPVLQAMGKNIFHVGASGAGQVAKLCNNMALGVIMAVTGEAIALGVAHGLDPKVLSQMMAVSTGRSWATEVCNPWPGVLENAPASRGYSGGFGSDLMLKDMGLAVEAAMSVGASIPLGEVARNLYSMNHQAGRGKLDFSSVVQLITSEK
>NZ_CP018756.1|WP_079224881.1|4518563_4518989_-|organic-hydroperoxide-resistance-protein
MSIEKVLYTAQATSTGGREGRSVSSDNVLDIQLSTPRELGGAGGPGTNPEQLFAAGYSACFLGALKFVAGQAKVALPADTTVTGKVGIGQIPTGFGIEAELTINAPGVPREQLEELVQKAHIVCPYSNATRGNIDVTLIVA
>NZ_CP018756.1|WP_079224883.1|4519098_4520079_-|cation-transporter
MAAPYNRAMALPSPRFFDPATEQGVLRLSIAFSLAVALAGVVFGLLANSSLIIFDGIYGLIDVVMTWLSLLVARLIALSTQTDALQSRLNQRFTMGFWHLEPIVLGVSGLLMIGAALYALVNAVDALMSGGRHIALGPAIVFGVVSLLAESAFGAFVWRANRRIGSDFIALDAKNWVIAASMSACYVAAFVGGVLVQGTSLAWVGPYIDPAILAVVCLFVMVAPLGTVRRALAGILLVTPPDLQAHVDAVARDIVARHGFVEHRSYVAQVGRGEQIELFFVVREDDPPRPLVEWDQLRDEIGDALGEASPDRWLTIMFTTDREWTI
>NZ_CP018756.1|WP_079224885.1|4520287_4521742_+|SulP-family-inorganic-anion-transporter
MQTSYPLRQQWLGNIRGDLLSGMVVALALIPEAIAFSLIAGVDPKVGLYAAFSIAVVTAIAGGRPGMISAATGAMALVMVDLVKGHGLQYLFAASILAGLLQVLAGVFKLGSLMRFVSRSVITGFVNALAILIFLAQMPELIGRGPTVYVLCAAALAIIYLLPRITRAVPSPLVAIVVLTAVVIGFGVDVRSVGDMGQLPDSLPHFLIPDVPLTWETLRILLPVSATLAVVGLLESMMTLQIVEDITETPSERNRECVGQGVANTVTGFLGGMAGCAMIGQSVINVTSGGRGRLSCLVAGALLLVLVVYGSDLVRQIPMAALAAVMIMVSIGTFSWRSLRDLRTHPRSSSAVMLLTVVVTVATHDLAKGVLSGVLLSALFFARKVGRMLGVQREDTADTQVYRVRGQVFFASAGQLGAAFDYQHVAPKVQIDLRDAHLWDLTAVAALERAQEKLATHGAQVTVVGLNAASQTLIEQVGGARGGH
>NZ_CP018756.1|WP_152027161.1|4521914_4523162_-|HNH-endonuclease
MNSNENEQFTHHLLKAAEQAVRLGYPPTRFKQMLNTYGGFDTVKRILMTGKPSDGFIKLLGYGRVDLTCEAIIVESHWRPFFDEDLLQRSEALLTSVGYKFQPFTSTEAAPLPTDSSISIAERLGLSAKAESKGTSAFFAEDLRAPLANVRWSWGSVDDVSRRVFLRLWEEDLQSHDGRTQIFVLDDKDTHRLGWQERQRHVALMERGYAGYGVICRSQEGGEGIAAYDSSQLIRLGTIRDRDECRYADVMDTVPVQSFRYTSPTPEEIAEDVTQVERNVEDPTTRTALIQARVGQGQYRARLESLWDSACAVTGCSVRAVLRASHCKPWRLSDDEERLNAENGLLLSANLDALFDAGLVSFDDEGRMLVADQLSVEERQLLNLPNGLRKRPTEALASYLKYHRELIFSKPKAWQ

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Crispr_ID: NZ_CP018756_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_28

4586064-4586159

Orphan

Consensus_repeat	Method
TGGTGGGTGCCGACCGTTGGTCGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_28

>merge|NZ_CP018756|28|4586064-4586159|CRISPRCasFinder
TGGTGGGTGCCGACCGTTGGTCGGCACTTCGATGGATGTTCATCCACGCATGGCGTGGATCTACCGGTGTGGTGGGTGCCGACCGTTGGTCGGCAC

>NZ_CP018756|28|27|4586064-4586159|CRISPRCasFinder
TGGTGGGTGCCGACCGTTGGTCGGCAC	TTCGATGGATGTTCATCCACGCATGGCGTGGATCTACCGGTG
TGGTGGGTGCCGACCGTTGGTCGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079224974.1\|4576683_4577436_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187604
NZ_CP018756.1\|WP_079224973.1\|4576103_4576592_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225008.1\|4596502_4597798_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341039
NZ_CP018756.1\|WP_079225483.1\|4594002_4594095_-\|potassium-transporting-ATPase-subunit-F	unknown	unknown	unknown
NZ_CP018756.1\|WP_079224981.1\|4581932_4583201_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513
NZ_CP018756.1\|WP_079224978.1\|4578487_4580176_-\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NZ_CP018756.1\|WP_079224994.1\|4586162_4586876_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP018756.1\|WP_079224983.1\|4583197_4583686_+\|dUTP-diphosphatase	unknown	unknown	gnl\|CDD\|234802
NZ_CP018756.1\|WP_079225004.1\|4594883_4595543_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP018756.1\|WP_079224995.1\|4586856_4589517_-\|sensor-histidine-kinase-KdpD	unknown	unknown	gnl\|CDD\|225115
NZ_CP018756.1\|WP_079225006.1\|4595705_4596506_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197336
NZ_CP018756.1\|WP_079224999.1\|4590212_4592270_-\|potassium-transporting-ATPase-subunit-KdpB	unknown	unknown	gnl\|CDD\|234905
NZ_CP018756.1\|WP_079224997.1\|4589568_4590216_-\|potassium-transporting-ATPase-subunit-KdpC	unknown	unknown	gnl\|CDD\|376890
NZ_CP018756.1\|WP_079225002.1\|4594222_4594867_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079224980.1\|4581078_4581705_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP018756.1\|WP_079224971.1\|4575551_4576019_-\|DUF1456-family-protein	unknown	unknown	gnl\|CDD\|227144
NZ_CP018756.1\|WP_079225481.1\|4580303_4581008_-\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NZ_CP018756.1\|WP_079225001.1\|4592280_4593990_-\|potassium-transporting-ATPase-subunit-KdpA	unknown	unknown	gnl\|CDD\|235494
NZ_CP018756.1\|WP_079224984.1\|4583698_4586056_+\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|100091
NZ_CP018756.1\|WP_079224976.1\|4577581_4578466_-\|SPOR-domain-containing-protein	unknown	unknown	gnl\|CDD\|225629

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079224974.1\|4576683_4577436_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.0297e-126
NZ_CP018756.1\|WP_079224971.1\|4575551_4576019_-\|DUF1456-family-protein	gnl\|CDD\|227144	COG4807, COG4807, Uncharacterized protein conserved in bacteria [Function unknown].	3.48451e-63
NZ_CP018756.1\|WP_079225008.1\|4596502_4597798_+\|MFS-transporter	gnl\|CDD\|341039	cd17486, MFS_AmpG_like, AmpG and similar transporters of the Major Facilitator Superfamily. AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.58262e-106
NZ_CP018756.1\|WP_079224994.1\|4586162_4586876_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.81361e-73
NZ_CP018756.1\|WP_079224981.1\|4581932_4583201_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
NZ_CP018756.1\|WP_079224978.1\|4578487_4580176_-\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NZ_CP018756.1\|WP_079224995.1\|4586856_4589517_-\|sensor-histidine-kinase-KdpD	gnl\|CDD\|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	0
NZ_CP018756.1\|WP_079224983.1\|4583197_4583686_+\|dUTP-diphosphatase	gnl\|CDD\|234802	PRK00601, dut, dUTP diphosphatase.	5.99423e-88
NZ_CP018756.1\|WP_079225004.1\|4594883_4595543_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	4.19977e-83
NZ_CP018756.1\|WP_079225006.1\|4595705_4596506_+\|exodeoxyribonuclease-III	gnl\|CDD\|197336	cd10281, Nape_like_AP-endo, Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Neisseria meningitides Nape and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Neisseria meningitides Nape and NExo. Nape, found in this subfamily, is the dominant AP endonuclease. It exhibits strong AP endonuclease activity, and also exhibits 3'-5'exonuclease and 3'-deoxyribose phosphodiesterase activities.	4.85254e-146
NZ_CP018756.1\|WP_079224999.1\|4590212_4592270_-\|potassium-transporting-ATPase-subunit-KdpB	gnl\|CDD\|234905	PRK01122, PRK01122, potassium-transporting ATPase subunit KdpB.	0
NZ_CP018756.1\|WP_079224997.1\|4589568_4590216_-\|potassium-transporting-ATPase-subunit-KdpC	gnl\|CDD\|376890	pfam02669, KdpC, K+-transporting ATPase, c chain. This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilize the Kdp complex. It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA. The K+ transport system actively transports K+ ions via ATP hydrolysis.	9.77389e-83
NZ_CP018756.1\|WP_079224980.1\|4581078_4581705_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.34143e-44
NZ_CP018756.1\|WP_079225481.1\|4580303_4581008_-\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	1.67407e-117
NZ_CP018756.1\|WP_079225001.1\|4592280_4593990_-\|potassium-transporting-ATPase-subunit-KdpA	gnl\|CDD\|235494	PRK05482, PRK05482, potassium-transporting ATPase subunit A; Provisional.	0
NZ_CP018756.1\|WP_079224984.1\|4583698_4586056_+\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|100091	cd03089, PMM_PGM, The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a bisphosphorylated sugar intermediate. The reaction involves two phosphoryl transfers, with an intervening 180 degree reorientation of the reaction intermediate during catalysis. Reorientation of the intermediate occurs without dissociation from the active site of the enzyme and is thus, a simple example of processivity, as defined by multiple rounds of catalysis without release of substrate. Glucose-6-phosphate and glucose-1-phosphate are known to be utilized for energy metabolism and cell surface construction, respectively. PMM/PGM belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the phosphoglucomutases (PGM1 and PGM2). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP018756.1\|WP_079224976.1\|4577581_4578466_-\|SPOR-domain-containing-protein	gnl\|CDD\|225629	COG3087, FtsN, Cell division protein [Cell division and chromosome partitioning].	9.85444e-19

>NZ_CP018756.1|WP_079224984.1|4583698_4586056_+|phosphomannomutase/phosphoglucomutase
MSGSGEGRQKQSLGRNAPLLGAALLLLAGWFGWSAVQQWRQQASGDTLAQVRDEAVQGVQQAASGQLLQLQQHLKGDRVQQSLQAGDAAGAAQALRESWSGVEQVDVLTAGLADAYADAATFGYARLALLESVLADGKPGLRVVRDGGGNRLGLAAPVQLGSLGPAVVYVRQPLLRLTSPLDQLRTPSSGFLSLRQGAHDIVAQGNTSLSDSAEAMARPIKGTPLRLTASAPNIDPGPLGLGALPSAIVALLLAFIAVLLVVGRGRLPKSLPLPARRAAAAEADHGPTLRESLQMAAPALPAADADDAGAGTPPAVPPPPPVDLPAGIFRAYDIRGVVGTELNARNAALIGQAIGTVALEQGLREVVVGRDGRLSGPELSASLAEGLRRAGCSVIDIGLAPTPLVYFAAFHLRTGTCVAVTGSHNPPEYNGFKVVIGGETLSGDAITDLYQRISEGRLAQAAAPGDYQQREVAADYIQRIADDVQLDRPLKVVADAGNGVAGAFAPQLLEAIGAEVIPLYCDVDGTFPNHHPDPSEPANLEDLVQTVKRFGADLGVAFDGDGDRLGVVTGEGKIIYADRLLMLFAADVLMRNPGAMVIYDVKCTGKLSDHVLRNGGSPLMWKTGHSLMKAKMRETDAELAGEMSGHFFFKERWFGFDDGLYAAARLLEILAQREETPHEVLEELPDMVSTPELKVPVASGTPHALVAMLVAAAQSEDNPYAGGRLSTIDGLRVDYPDGWGLVRASNTTPVLVLRFEGNDTAALERIQALFRSQLQGLLGDTPLGF
>NZ_CP018756.1|WP_079224983.1|4583197_4583686_+|dUTP-diphosphatase
MTQATSTPVAPLQALQVKLLDPRFGDSWPLPAYATEASAGMDLRAALETALTLQPGDTALVPSGLAIHIGDPNLCAVILPRSGLGHRHGIVLGNGTGLIDADYQGPLLISVWNRGREAFTIEPGDRIAQLVVVPIARVSLQVVDTFTDSVRGTGGFGHTGVR
>NZ_CP018756.1|WP_079224981.1|4581932_4583201_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MADSPNALPAPARALEGQKLLLCVGGGIAAYKALELVRRLRDAGALVQVAMTAGAQQFVTPLSFQALSGQPTRTTLWDSAAEQAMGHIELARWADRIVVAPGTADLLARLAQGHADDLVSTLCLASTAPLTVCPAMNHRMWLHPATQANIALLRQRGAQVIGPVDGPLAEGESGPGRLAEPGDIVAALASLGGTAPAARPAAPETRALQGLRLLISAGPTYEDIDPVRYVGNRSSGKMGFALAGAAAALGAQVVLVSGPVQLPTPPGVQRVDVRSAAQMREAVLNALPADIYIGAAAVSDYTPRQVAAQKLKKTADSQSLVIELVRTPDILAEVAAQTQSLKLVVGFAAETHDVEKYARGKLVDKRLDLVIANQVGISGGGFESDNNAATAFWQDGEQVFPATSKRELAEQLLALIARRLQA
>NZ_CP018756.1|WP_079224980.1|4581078_4581705_-|response-regulator-transcription-factor
MPPRIIIADDHPVVLHGIRIVLERHNMCVTGAASDGAALLDLVARRRCHAVLTDLVMPGTGPDGPELLGTLRHRYPALPVVVLTSARHPGLLDSLLRDGVQGLIDKSADFAELPRALRAAIAGRTFVSRQLRRLLESRDLLLQRVPCAPSAREQEVLDLLGEGLSVNAVAEHTGRSAKTISRQKAEAMRKLGLDNNQELYDYLQAQRA
>NZ_CP018756.1|WP_079225481.1|4580303_4581008_-|DNA-repair-protein-RadC
MPIHDWPIDERPREKLLTRGPTALSDAELLALFLGSGFGGRDAVQTARDLLGSHGPLRVLLDRPAAKLARLPGLGPARSCTLAAGLELAHRYLAAELAHGESVGDNPLAVGRYLQHRLRGQARELFLVLFLDNRHRLIACEELFAGTINTAPVYPREVVRRALLHNAAAVILSHNHPSGDPEPSGADARITEELQQALALVDIRLLDHFVIGEGRPVSFAERGLLPQLQPRLFG
>NZ_CP018756.1|WP_079224978.1|4578487_4580176_-|arginine--tRNA-ligase
MKNLLRALISQGIEALRANGTLPADSLPPDFVVERPKTRDHGDFATNAAMLLAKAARSNPRALAQALVEALPRSEDVSKVEIAGPGFINFHLAPAAYQREAASVIKEAHDYGRNLSGNGRTVGVEYVSANPTGPLHVGHGRAAAIGDCVARVLDANGWNAKREFYYNDAGVQIENLALSVQARIKGIAPDQDGWPEGGYRGEYIADVARAYLAGASVDLEGTMVVGAKDPDDMTAIRRFAVAYLRNEQNLDLAAFGVDFDIYFLESSLYADGKVAEAVAKLQASGHTYEEGGALWLRSTDFGDDKDRVMRKSDGTFTYFVPDVAYHLSKWQRGYERAITELGADHHGSLARVRAGLQAMEVGIPQGWPEYVLHQMVTVMRGGEEVKLSKRAGSYFTLRDLIEEAGRDATRWFLIARKPDSQLTFDIDLARQQSNDNPVFYVQYAHARVCSLLRQAQEKGLVYDQGNGLGNLGRLADDASLLLMNEISRYPEVVEAAGVALEPHLVAQYLRELAHAFHTWYHGTPVLVDDATDRNAKLTLACAARQVLANGLDLLGVSAPEKM
>NZ_CP018756.1|WP_079224976.1|4577581_4578466_-|SPOR-domain-containing-protein
MAARRGKSQARRNSSSQGTPGWVWLVAGVAIAAVVFLAAPNLFKGEGDGFLRAGPQPNPNAQPAPVADADSDVGSQPVEAPATPKPAEPAKPAATQYDFYTLLPGKEVEMSDAELAASTRAEELRRAKAEAQRAQAALEGKPVPAAAAAAPAATPSVATATPATPAARPLPAPLSERPATPSASAAAPASTSTAATTPAARAEAAQAAAAAPAAAADNARYILQAGAFGASGDAEATKAKLAMMGLAARVESAQINGKTVYRVRMGPYGSAGELSEAKQKLDGTGLQAMAIKAQ
>NZ_CP018756.1|WP_079224974.1|4576683_4577436_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTRTVLITGATSGFGAAAVHRFAQAGWKVIATGRRGERLQPLVDRYGKDVVHAAVFDVRDPVAMEAALLALPPAFGDIDLLVNNAGLAQGTAPAQNAKLSDWTTMIDTNITALVTLTHRLLPLLVERKGAIINISSVAGVYPYPGGNAYGGTKAFVSQFSLGLRSDLHGTGVRVTTIEPGMAETEFTVVRTHGDQAASDKLYTGANPMTAEDIAEQIFWVATLPPHLNINRLELMPVSQSFAGFQVAREG
>NZ_CP018756.1|WP_079224973.1|4576103_4576592_+|hypothetical-protein
MRRFLLSALLVASSFAATAQDRFVPVEQRLTAAQLAEVGLSPAQLQALNRVMREAETAAPAPAALAARPAAPLPANVPAPAAMHLGLEEGPVTARVVGDVAGWEPGTVFTLDNGQQWQVMKGQMKLRRNLQAPQIEVIPGIAGRWFLQVDEDLPKARVFRLR
>NZ_CP018756.1|WP_079224971.1|4575551_4576019_-|DUF1456-family-protein
MINNDVLRSVRYALDLGDHHVVTLCQMADPAFVVDTEQVKAWLRRDDEAGFEAMNDGALAHFLDGLIVHLRGRDESQPLRAVETRIDNNLVLKKLRVAFQLRDVDLMEIFASVGFKVSKSELGALFRQPGHTNYRRCLDQMLRNFLKGLSLRVRG
>NZ_CP018756.1|WP_079224994.1|4586162_4586876_-|response-regulator-transcription-factor
MSPTPIDASVPAARVLVIDDETQIRRFLDISLRAQGYQVRQAATGQEGLDMAASEDMDLVILDIGLPDMEGHEVLAQLRQWSQVPVIMLTVRAGEHEKVRALDTGANDYVTKPFGTQELMARVRALLRTRSVPSDGTPPVFDDGHLHVDLVRREVAIDGEPVALTRKEYALLSLLLRNAGRVVTQPQILQEIWGPTHQQDTHYLRILVGKLRHKLGDSALDSRYLFTEPGVGLRFKG
>NZ_CP018756.1|WP_079224995.1|4586856_4589517_-|sensor-histidine-kinase-KdpD
MNDARTRQADALVEGLQREAGGKLTVFLGAAPGVGKTYTMLTRAQEQLRRGVDLVVAVVETHGRVDTQALLEGLPQLPLKGVAYHGHALQEMDLDAVLERHPALVLVDELAHRNAPGSRHERRWQDVMELLDAGIDVWTTVNIQHLESLNDVVMRITGVRVSETVPDGVLDRLHDIVLVDLPPRELIARLQQGKVYVPEQAAQALQAFFSPANLTALRELAMQEAADRVDSSLRETRAARGEGNLPLRRGVLVAIDGGGQSEYLVRVARRIAERRDAPWTVVTVQGRRQDEATRREIDAAFALARRLGGEAELLHGSSIADALLDHAAHNGVSTLVLGRTRERPLARMFNRTLTQQLIQRGAHYEITIISTPQARARARREGLLPPMRGISHEPLQALLATALACGVAWLGERWVGMADLSMVFIVAVVLVAARTRASVAVMAAILCFLAYNFLFIAPRFTFAIGARQGVITVFLFLAAALVAGRLASRLRMQVIALRAANRHARARQQLGRQLASAAGNGEVAQAGRQALEQAMDVPAWLRIGADTATGGGAQPGDTDLAAADWALRHRQPSGRFTDTLAGAQWWFLPLLDGEDRAVGVAGLYLPGAQARLLPEQRQLAEAMVDDIAQAALRTQLVAELEQAHVSNETERLRSALLSSVSHDLRSPLAAMIGSADSLASYGTAMDAADRRALLDTILVEGERLDRYIQNLLDMTRLGHEGLTIQRDWIGVDELIGSAARRLQRYQPKVRLELDIPATLAPIWVHPALVEQAVFNVMENAAKFSPPDAPVQVLARELDGQLRIDVIDAGPGIPDDERARIFDMFYSVERGDRGRHGTGLGLTICQGMIGAHGGSVQALPGRDGRGTLIRITLPLLKPAAHDEPDPD
>NZ_CP018756.1|WP_079224997.1|4589568_4590216_-|potassium-transporting-ATPase-subunit-KdpC
MNRSVSSSSLPREHAAEARVARLQDDATWRPAIGLGLATLLLAGAVYAGIATGFAGLSYPTQAEGSLLRDGSGQVRGSAWLAQPFTGDGYFQARPSAANYDPMAAAGSNLARSNPALAERVAASTAAVAAREGVSPAQVPADLVTQSGAGLDPQLSPAAAQVQVARVARARGLPVERVQALVQAHTEGRQWGLFGQPRVNVVTLNFALDHAARAP
>NZ_CP018756.1|WP_079224999.1|4590212_4592270_-|potassium-transporting-ATPase-subunit-KdpB
MSTHASSSRSSLAPRPALLDGAGLRSALVEAVRKLAPMHLVRSPVMAVVMAGTIVAAIVTLTGNAPLGFGLAVTAILLVTVLFGNFAEAVAEARGRGQAASLRRARQDLVARRLAAPQPGAAEAQVPAAELRPGDHVIVSAGELVPADGEIVQGLATINEAAVTGESAPVLREAGTDRSGVIGGTKVLSDQIIVRVTAEPGHSFLDRMIALVEGANRQKTPNEVALTLLLAAMTLTFLVVVATLPAIGAAVGVQVDPLLLIALLVCLIPTTIGGLLPAIGIAGMNRALAANVLAKSGKAVEVAGDVDVLLLDKTGTITYGDRQASHFHPLAGIDASQLREAALLSSLADPTPEGKSIVRLAREQGCATAEPEQADYLAFSAQTRMSGVDLEHGRQIRKGALDAIRNHVQALGGTVPAELAGRVEQVARDGATPLVVAEGRHVLGVIELSDVVKHGMREKFAQLRAMGIRTVMITGDNPLTAAAIAAEAGVDDYIAEARPEDKLARIRQEQAGGRLVAMVGDGTNDAPALAQADIGLAMNSGTQAAKEAGNMVDLDSDPAKLLAVVEVGKQQLITRGALTTFSLANDVSKYFAILPALFAAAVPTMAALNVMQLSSPRNAVLAALIFNALVIPALIPLALRGVRFRPATATALLRRNMLVYGLGGVLLPFAAIKAIDLLLVLVSGA
>NZ_CP018756.1|WP_079225001.1|4592280_4593990_-|potassium-transporting-ATPase-subunit-KdpA
MTEMLVILAASLLLAWPLGLYLARVMRGAPMKVDVLFHWIEKPLYRLFGVDAARSMSWRGYVLAFVLSNVVVAVLTQAVFMTQAWLPLNPDQIPNMRWDTALHTMISFLTNTNQQHYSGQAQLSYLSQMTGITGLQVVTPMMGLALAVATLRALFARAPQTVAAPAAGGDRQVPVGNYYVDVVRLCVRFLLPLCLVWTLLLTSQGVPSTMAGGPQATPIDASAGMAQQKLPLGPVAAMVAAKQLGANGGGWYGPNSSFPLENPTPVSNLLEVVGILLIPMAVIFMIGAFTGRRRFGALVFSCMLGMSLLSTGAMMWSEGHSASAATPLLMEGKEVRFGADGTALWAAVTTQVSNGSVNGMHDSLAPLSGGIAMVNMLVSAIWGGIGCGLQQFIVYLLLGVFLAGLMTGRTPELFGRKLETPQVRLLALLVLLQPITLLVFTAITLAVPGLSGTSNPGFHGISQVFYEYVSAYANNGSGFEGLGDATPWWNLSCSLVLLLGRFPLLIIPLVVAAQLAAKRQAPESAGSLQIETPTFALTLVSVIVILTVLQFMPALVLGPIADHLSLGLH
>NZ_CP018756.1|WP_079225483.1|4594002_4594095_-|potassium-transporting-ATPase-subunit-F
MSPWLSLFCGVLVLVAAAYLLYVVLRPESF
>NZ_CP018756.1|WP_079225002.1|4594222_4594867_-|hypothetical-protein
MFRVPAIVATGLLLALPASLLAQSGAPGKKLYCWNEGKERICSDSLPADAVNNAREEFNANSGVRNAQVQRALTDAERAAAATVAAQAQLDQMAAQTKQRTEQAMLSTYGSEDALRKVFNERQEVLDNNLSTARYNVTSLRDSLVTLLGAAGDRELAGGKVGDTQAEAIRQRHAQLQAQQRLQASFEQQQVTLKAEIDASLQRYRELKGMAPGG
>NZ_CP018756.1|WP_079225004.1|4594883_4595543_-|orotate-phosphoribosyltransferase
MSDHRHRFLQLALTADALRFGQFTLKSGRLSPYFFNAGRFDSGSLLSQLGACYSDAIDASGIKYDVVFGPAYKGIPLATAMACELAQRGRDLPLSFNRKEVKDHGEGGQLIGADLTGKRVLIVDDVITAGTAIREALAIIRAAGGIPAGIVVALDRQEIASEADPRSAAQAVAEEAGIPVIAVATLADLLDFASGNPELVGYRQPLEAYRAQYGVRSAR
>NZ_CP018756.1|WP_079225006.1|4595705_4596506_+|exodeoxyribonuclease-III
MRIISFNANGIRSAATKGFLDWFRAQDADVLCIQETKAQEDQLTDPMFRPDGHHCFYRDAITKKGYSGVAIYSKREPDQVITSLGWAPFDDEGRYIEARFGNLSVVSFYIPSGSSGDLRQGFKFEVMEWLRPILEEWARSGRDYVLCGDWNIVRSALDIKNWKSNQKNSGCLPEERDWLNGLCADHGQATDVATGRGWADAYRLLHPAGEDYTWWSNRGAARANNVGWRIDYQFITPGLRDRLRSCSIYRDERFSDHAPFTVDYDL
>NZ_CP018756.1|WP_079225008.1|4596502_4597798_+|MFS-transporter
MSEAAAKPSYKGWAGIKRAFGTPSALTMALLGFGSGLPFLLIASQTLSTRLRDVGLDLGSIGLISLASFFYLLKFVWAPLLDRYAFPLLAFLGRRRSWLLLSQVAVLIGLVALAFVRPEQGVWPLVAWVLVASFAGATQDSVVDAYRIEIAPETAQAALAATYTLGYRIGLILAGAGALYLAQFEGWIVAYLAMAGLMLLPIITTLVCREPDRPAQAVQRRIDVAEAFVKPITSFFTRNGIGLALGLLAFVGLFKFPDQVIGVMAGPFYLDSGFDKADIATVSKLFGVWMGIGGAFLGGISVAALGFRRMLLVAALGVALSNLAFLLMAHNPGQLWAFYAALSADNLFQGFAGTVLVAFMSSLTDRNFTATQYALLVSLANLPGKFVGGVSGYIVEASSYSTFFMLSAVTVVPTLLLLAWLWPRIHDRSAS

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Crispr_ID: NZ_CP018756_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_29

4631374-4631476

Orphan

Consensus_repeat	Method
GCAGCCGACCAACGGTCGGCTCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_29

>merge|NZ_CP018756|29|4631374-4631476|CRISPRCasFinder
GCAGCCGACCAACGGTCGGCTCTACAACAGCGCAGAGCAGCCGACCGGTAGAGTCGACCGTTGGTCGACTGGCGAGATGCAGCCGACCAACGGTCGGCTCTAC

>NZ_CP018756|29|28|4631374-4631476|CRISPRCasFinder
GCAGCCGACCAACGGTCGGCTCTAC	AACAGCGCAGAGCAGCCGACCGGTAGAGTCGACCGTTGGTCGACTGGCGAGAT
GCAGCCGACCAACGGTCGGCTCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079225020.1\|4620872_4622300_+\|outer-membrane-protein-transport-protein	unknown	unknown	gnl\|CDD\|367457
NZ_CP018756.1\|WP_057497455.1\|4629698_4631306_+\|cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|238833
NZ_CP018756.1\|WP_079225044.1\|4635906_4636800_+\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP018756.1\|WP_079225023.1\|4628191_4628668_+\|DUF2244-domain-containing-protein	unknown	unknown	gnl\|CDD\|378350
NZ_CP018756.1\|WP_152027163.1\|4638052_4638454_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225046.1\|4636967_4637777_+\|calcium-binding-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225024.1\|4628679_4629639_+\|cytochrome-c-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224537
NZ_CP018756.1\|WP_079225042.1\|4634738_4635902_+\|COX15/CtaA-family-protein	unknown	unknown	gnl\|CDD\|367131
NZ_CP018756.1\|WP_079225040.1\|4634158_4634728_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225022.1\|4624698_4627917_-\|bifunctional-proline-dehydrogenase/L-glutamate-gamma-semialdehyde-dehydrogenase-PutA	unknown	unknown	gnl\|CDD\|237017
NZ_CP018756.1\|WP_079225489.1\|4622438_4622879_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_152027164.1\|4638450_4639203_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_049468560.1\|4633071_4633290_-\|twin-transmembrane-helix-small-protein	unknown	unknown	gnl\|CDD\|378564
NZ_CP018756.1\|WP_079225019.1\|4619951_4620644_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP018756.1\|WP_079225039.1\|4633347_4634064_+\|SURF1-family-protein	unknown	unknown	gnl\|CDD\|119401
NZ_CP018756.1\|WP_079225021.1\|4623574_4624642_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273670
NZ_CP018756.1\|WP_079225491.1\|4622988_4623588_+\|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl\|CDD\|377432
NZ_CP018756.1\|WP_079225028.1\|4632175_4633051_+\|cytochrome-c-oxidase-subunit-3	unknown	unknown	gnl\|CDD\|238834
NZ_CP018756.1\|WP_079225018.1\|4619496_4619916_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|169406
NZ_CP018756.1\|WP_079225026.1\|4631571_4632162_+\|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl\|CDD\|235341

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079225020.1\|4620872_4622300_+\|outer-membrane-protein-transport-protein	gnl\|CDD\|367457	pfam03349, Toluene_X, Outer membrane protein transport protein (OMPP1/FadL/TodX). This family includes TodX from Pseudomonas putida F1 and TbuX from Ralstonia pickettii PKO1. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.	9.66173e-121
NZ_CP018756.1\|WP_057497455.1\|4629698_4631306_+\|cytochrome-c-oxidase-subunit-I	gnl\|CDD\|238833	cd01663, Cyt_c_Oxidase_I, Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.	0
NZ_CP018756.1\|WP_079225044.1\|4635906_4636800_+\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	3.86948e-136
NZ_CP018756.1\|WP_079225023.1\|4628191_4628668_+\|DUF2244-domain-containing-protein	gnl\|CDD\|378350	pfam10003, DUF2244, Integral membrane protein (DUF2244). This domain, found in various bacterial hypothetical and putative membrane proteins, has no known function.	5.37523e-28
NZ_CP018756.1\|WP_079225024.1\|4628679_4629639_+\|cytochrome-c-oxidase-subunit-II	gnl\|CDD\|224537	COG1622, CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion].	2.00775e-74
NZ_CP018756.1\|WP_079225042.1\|4634738_4635902_+\|COX15/CtaA-family-protein	gnl\|CDD\|367131	pfam02628, COX15-CtaA, Cytochrome oxidase assembly protein. This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus subtilis. COX15 is required for cytochrome c oxidase assembly in yeast.	1.6123e-54
NZ_CP018756.1\|WP_079225022.1\|4624698_4627917_-\|bifunctional-proline-dehydrogenase/L-glutamate-gamma-semialdehyde-dehydrogenase-PutA	gnl\|CDD\|237017	PRK11904, PRK11904, bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA.	0
NZ_CP018756.1\|WP_049468560.1\|4633071_4633290_-\|twin-transmembrane-helix-small-protein	gnl\|CDD\|378564	pfam11137, DUF2909, Protein of unknown function (DUF2909). This is a family of proteins conserved in Proteobacteria of unknown function.	1.47132e-15
NZ_CP018756.1\|WP_079225019.1\|4619951_4620644_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	2.24692e-27
NZ_CP018756.1\|WP_079225039.1\|4633347_4634064_+\|SURF1-family-protein	gnl\|CDD\|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	3.58378e-37
NZ_CP018756.1\|WP_079225028.1\|4632175_4633051_+\|cytochrome-c-oxidase-subunit-3	gnl\|CDD\|238834	cd01665, Cyt_c_Oxidase_III, Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. CcO catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, is believed to play a role in assembly of the multimer complex. Rhodobacter CcO subunit III stabilizes the integrity of the binuclear center in subunit I. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit III contains bound phospholipids in several crystal structures and is proposed to contain a "lipid pool." These phospholipids are believed to intrinsic constituents similar to cofactors of the enzyme.	9.52026e-92
NZ_CP018756.1\|WP_079225491.1\|4622988_4623588_+\|nicotinamide-mononucleotide-transporter	gnl\|CDD\|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	2.68992e-47
NZ_CP018756.1\|WP_079225021.1\|4623574_4624642_+\|AAA-family-ATPase	gnl\|CDD\|273670	TIGR01526, nadR_NMN_Atrans, nicotinamide-nucleotide adenylyltransferase, NadR type. The NadR protein of E. coli and closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal to the region covered by this model, is a DNA-binding helix-turn-helix domain (pfam01381) responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologs in Mycobacterium tuberculosis, Haemophilus influenzae, and others appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this model share that activity.	1.732e-42
NZ_CP018756.1\|WP_079225018.1\|4619496_4619916_+\|hypothetical-protein	gnl\|CDD\|169406	PRK08366, vorA, 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha; Reviewed.	0.00744266
NZ_CP018756.1\|WP_079225026.1\|4631571_4632162_+\|cytochrome-c-oxidase-assembly-protein	gnl\|CDD\|235341	PRK05089, PRK05089, cytochrome C oxidase assembly protein; Provisional.	6.8366e-83

>NZ_CP018756.1|WP_057497455.1|4629698_4631306_+|cytochrome-c-oxidase-subunit-I
MAHSAVGHDDHHHHQSFFERWFFSTNHKDIGTLYLGFSFIMFIIGAAMSVVIRAELAQPGLQFVKPEFFNQMTTVHALVMIFGGVMPAFVGLANWMIPLQIGAPDMALPRMNNWSFWLLPVAFSLLLLTLFLPGGAPAGGWTLYPPLSLQGGYNVAFSVFAIHVAGISSIMGAINIIATVLNMRAPGIDLLKMPIFCWAWLITAFLLIAVMPVLAGAVTMLLTDKFFGTSFFNAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGVVSEIIPTFSRKPLFGYQAMVYATAAIAFLSFIVWAHHMFTVGMPLGGEIYFMFATMLISIPTGVKVFNWVSTMWRGSLTFEAPMLWSVAFVILFTIGGFSGLMLAIVAADFQYHDTYFVVAHFHYVLVTGAVFALIAAVYYWWPKWTGRMYSEKWAKVHFWWSIVFVNLLFFPQHFLGLAGMPRRIPDYSVAFADWNLISSIGAFGMFATPFMMAAILLSSLRNGEKAEARSWEGARGLEWTLPSPAPAHTFTTPPTIRPGDLAHDDITH
>NZ_CP018756.1|WP_079225024.1|4628679_4629639_+|cytochrome-c-oxidase-subunit-II
MKQSSRWGTKCVAAVASLVAGGLVPAWAWAQAADPKPWQLNMGKGVTQTSRLAWESNNLSLIICTVIGVIVFGAMAYAIFKFRKSKGAVAATFSHNTKAEVIWTVIPVIILIVMAWPATANLIKMYDTRDAEMTVKVTGYQWMWKYEYLGENVTFTSRLDRESDRVRQSGVVPTRESHPHYLLDVDNRLVLPVDTKVRFVITSDDVIHAWWVPALGWKQDAIPGFINEAWTSIEQPGVYRGQCAELCGKDHGFMPIVVEAVSKEDFKQWLAQRKPAPAAPATPAAPAEPAAPAGEAPAAPAAPAAAEAGDTPATAASGA
>NZ_CP018756.1|WP_079225023.1|4628191_4628668_+|DUF2244-domain-containing-protein
MIEVLPAPDGSGTQLRLRPPRALDARQFILLFAVLSGAMWLVSALGWLAGNAFAPLFALLYSLLLAAALRALWRSGERQEEIRVVPACVEVIPVPGGSPVFRAHPHWVRLLTDDERVRLASSGRQVEVGSFLAPAERQTLAEMLEGLLAASDGGNRRR
>NZ_CP018756.1|WP_079225022.1|4624698_4627917_-|bifunctional-proline-dehydrogenase/L-glutamate-gamma-semialdehyde-dehydrogenase-PutA
MNAPSSSPAAHDAPRPGALLSPELPASPNPFRQAITDAWLKDEASHVRELLAQARLPAEEQARVQALAADLVGRVRVRAKDQGAIEAFMRQYDLGSEEGVLLMCVAEALLRIPDQDTADKLIRDKLADADWEKHLGGSDSVLVNASTWGLMLTGKLVQMNDATRADAPSAFKRLVGRVGEPVVRLAVRQAMKIMGHQFVMGRTISEALSRSHKGDNASYRYSFDMLGEGALTMKDALRYLEDYRRAIHAIGGDHKARGGRPDGDVNNAPGISIKLSALYPRYEHAKRERVLTDLVPGVLELAQLAKSYGIGCTVDAEESDRLELSLDIIEQVFGDASLAGWDGFGVVVQAYQKRTPYTIDHLADMARRAGRRLQVRLVKGAYWDAEIKRAQIEGYPGYPVFTRKQNTDVSYLACAKRLFTHADAIYPMFATHNAHTIAAVRSIANGGVYEHQKLHGMGDDLYAEVVPADRLGLPCRVYAPVGSHEDLLPYLVRRLLENGANSSFVNRITDERVPIADLIRDPVEMVASFASIPHPKIPLPVDLLRSQNHDRKNSMGANLANDNELRALAEQINAAVKPWQAAPLVPGANPTGAALPVANPADTREVVGQWLAADAATVQKALANAVSAQPAWNRTPAASRAAILEHAADQLEARMPEFMALCVKEAGKSLPDSIAEVREAVDFLRYYAKQAREQFSHAEKLPSPTGESNELQLHGRGVFVCISPWNFPLAIFLGQVAAALAAGNSVIAKPAEQTNLIGYYAVKLLHDAGVPAEVVQFLPGDGATVGAALTADPRVAGVAFTGSTDTARAINRAMAARDAAIGVLIAETGGQNAFIADSSALPEQLVKDAIGSAFTSAGQRCSAARVLFVQDDIADKVMTMLAGAMKELKVGNPGLLSTDVGPVIDADALKILQDHAERMDREARLIAAAELSAEAASGTFFAPRAYELKDLGQLQKEVFGPVLHVIRWKGDQLDAVIDQINATGYGLTLGVHSRIDETVDRISNGVHVGNVYVNRNQIGAVVGVQPFGGQGLSGTGPKAGGPHYLLRFATEKTVTVNTTAAGGNASLLTLGD
>NZ_CP018756.1|WP_079225021.1|4623574_4624642_+|AAA-family-ATPase
MPLPERVERGLVVGKFCPLHRGHERLIDFAASRCRALLVISWSQPGFAGYSAARRERWLRARFPQATVAVLDDARLAALCELHGLPPRVLPRDDDSEQAQRDFTAWLCLHLFGGPVQAVFTGEDYGDGFAAALAGHFNAPVQHQRLERSLDVGQASGTVLRADPHTHRQSLSAEVYAAYVQRVAFIGGESTGKTTLARVLAERMGTQWVPEYGRTLWEAQGGELQAQDLLRIAEEQPRREEAAALAAQRWLFCDTTPLVTLGYSGWMFGTAPQALLQAALRPYDLLFLCAPDIAFDQDGTRVGESFRAQQHAWYVRELQARGVGYVLLEGDLETRIARVQDALAERADHRFSVVA
>NZ_CP018756.1|WP_079225491.1|4622988_4623588_+|nicotinamide-mononucleotide-transporter
MNLTDPNFQLELAANIAVAGSILLAGRNNVHTWWMGIVGCALFAAVFERSHLYADMVLQFFFIAISVLGWWQWLRGDHGAPLPITPVRPRAWAWLLPLAVVATVAYGWMLTRLTHAYAPYIDSAVLVLSVIAQILMMRRKLESWWVWLLVNTIAVPLYYSRGLHLTSILYIGFWINALVALRHWRNLMRAEAGAADAAA
>NZ_CP018756.1|WP_079225489.1|4622438_4622879_+|hypothetical-protein
MALTRKGKYWYGDEDGDIAAVIGNYSRAAGYPATLFRAALCSCGSARFHLFDDEVEGVARRDCVACGESHLMFDSAEYLADANLDEHVCMCDNAALSIHCGVALYEGTQDVRWLYIGCRCADCGMVGVYADWKCEGGPVEAFMARV
>NZ_CP018756.1|WP_079225020.1|4620872_4622300_+|outer-membrane-protein-transport-protein
MQTASTIARLTLLAVGVAGALAAADANAAAFQLKENSAKGLGRAFAGSTSAEGDASVVATNPASMRLLDGTQFQGDVSAISFGAKFRGEGQYGNGAPISGGNGGDAGMIAPVPAAYFHVPFGEKDNMHFGASLTVPFGFKTEYDTDWVGRYNGVKTDLKAIDLGVAFSYDINPYLSFGVGVFAERLNVDLTSAVDAGTAINASAQQRASAAVLAAGGTPAQAAAAARQAAAQAAQLGFSPGSADGNLRIKGDEVSVGYTLGMTVSPVEGTNIAFSYRSEVEHKITDGKADFTMTPAAAAFLAQAAPGTFIDSNGRATITLPASATVSVSHRVNDQWKIMADVSRTAWSKFDKVTVDYDSNQPDSVLPFNYRDTTFASIGTEYRLNDQLTLRGGVAYDQTPTTDAHRDVRVPDTTRKWLSLGLTYAASEKMEYSVGYTHLFTKDPNITSTSATGNTVTGKYKVSGDVLAASMQYKF
>NZ_CP018756.1|WP_079225019.1|4619951_4620644_-|rhomboid-family-intramembrane-serine-protease
MFVSLPSRKKATLRWATPVLFAALWLAFLWSISRPGDARNSLWLDWGALSTGLTHPLDWWATLQDGSVLRLFTALFLHADWSHLLGNLVFLLIFGLPAERVLGPWRLMLLFLVGGAVSNLVAIYTMGSPDQIIIGASGAVSAMIGAYLALFPAARLGVVIPLGLFLEFVRAPAYLLIGVWAALQVVFAHIGPSFGMVAWWAHIGGFVFGLLYGVYVRAAIARKLRKRHGF
>NZ_CP018756.1|WP_079225018.1|4619496_4619916_+|hypothetical-protein
MDDADVATLIAGRLGREPWAPGVAGPWLDALAHRHCIAPDRVLWWDGAPATQVHACYDDGMQGLARLEELLAPAQGEIQLIVSEECAPPWPVWSLQASELLPLLGELPFFEYAVVLDGGATLVFDTHHNTLLVSRARNR
>NZ_CP018756.1|WP_079225026.1|4631571_4632162_+|cytochrome-c-oxidase-assembly-protein
MSEAPATAPSRSAGLPRLIGVAVAVFLLTFSLVPLYRIACEKVFGVRLERGPGSEASTGAAAGKRTVRVEFDGGVNSRLPWSFHPEQLTMDVVPGELNEALYFARNDSANAVVGSAVPSVAPARASGFFSKTECFCFTAQTLQAGEKRDMPVRFIVDPDLPPEIRTITLSYTFYRNDALSDRLAPAATSEGAHAAP
>NZ_CP018756.1|WP_079225028.1|4632175_4633051_+|cytochrome-c-oxidase-subunit-3
MAQTPTDANVYFVPAQSRWPFVGSIAMMVTMVGVASWLNDASWGRWTFYIGIAMLVLTLFWWFSDVVRESQAGHYNRQVDGSFRMGMVWFIFSEVMFFGAFFGALFYTRNLGLSWLSGEGRGVMTNELLWQGYSAGWPTNGPAAIGGAFQTIPAWGLPLINTLILLTSGVTLTIAHHALKAGNRRQLLVWLGVTVLLGLGFLTLQAEEYIHAYKELNLTLGSGIYGSTFFMLTGFHGAHVLLGTIMLIVMWLRSAKGHFTRDNHFAFEAAAWYWHFVDVVWLMLFMFVYVL
>NZ_CP018756.1|WP_049468560.1|4633071_4633290_-|twin-transmembrane-helix-small-protein
MSDSLKTLLVIAFLIVIVWNLGAGLYYLLVDRGQTKRTVNALTRRIGVSVALIVLVIVCIYMGWIKPHGIGG
>NZ_CP018756.1|WP_079225039.1|4633347_4634064_+|SURF1-family-protein
MMRQHTRVIGWLMAVLAMAAFTALGFWQLQRMHAKQAMLDAQGPATAQALPLAQALAAPGALHGVADHGRFLPGVVLLDNQMRHGRAGVKIYRPFQSDGGSVLLVDLGWRALPPDRTLPQLPAPPSPVAVRGLLAPPPAAGLALGPALSPTGEAGRWLASRLPADGLARALGLAALPDRVLRLDPALPFGDERDLDLLPNTLPPQRHLGYAVQWFGLALTVLVVALVLERRRKRPMAR
>NZ_CP018756.1|WP_079225040.1|4634158_4634728_+|hypothetical-protein
MNTATSPQARGSGRRTLVLLFAVFFGAMALAAVLRFTGWQPTAHRNAGQLLEPPVDLRQQPPTLANGQAYPWNPEARTWRLLVAPAGGCDAQCVTLSQGLGKVWQLFGHNADNVEILWLGTPPASIASLPALRPLAPSPALRAALPGVDDPAGLPVYVIDPNGFVIMRHAPGSDLGGLRKDMATLLKLK
>NZ_CP018756.1|WP_079225042.1|4634738_4635902_+|COX15/CtaA-family-protein
MSLSARPALHRNFHRLAWFAMIMTASTIMFGAFVRLSDAGLSCPDWPTCYGQATWPQHVEETIGHPAAEIRPLETHKAWREQVHRFLAGALGIEILTLALLATRKRRFGSTAVVTACVLVAAGIPLYMMGWHGTASALALVGEAILLLAALRWSNIDLARAALLTLAVVIFQALLGMWTVTLLLKPIVVMGHLLGGMLMFALLVWMAWRATHLPITLAEAPKLKWLLRIGVAVLVTQIALGGWVSANYAALACGGGSASLDNFPRCANQWWPQHNFAEGFTLWRGIGVDYEGGVLDGASRIAIQMAHRLFAIVVAAYLLWLGLRLFRVPSMRGWASALVALLVLQVTLGILNVKLALPLEVAVAHNGVAVALLFVLVSLLARLRAPD
>NZ_CP018756.1|WP_079225044.1|4635906_4636800_+|protoheme-IX-farnesyltransferase
MFSNYRQYWDLTKPKVVALIVFTALVGMVLAIPGVPSWEQVRAGALGFLGIWLAASAAAAINQLLDAHIDAQMARTSWRPLVVGKVKPWQVLVFASVLIVLSMAILLLWVNWITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGAMPPMLGWAAITGMQGSSDWAYSSLLVLIIFIWTPPHFWALAIFRREDYAKAKIPMLPVTHGVVHTRKQIMVYSVVLALVCVVPYLVGMSGPFYLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFHYSIVYLMALFAFLLVDHWILPWL
>NZ_CP018756.1|WP_079225046.1|4636967_4637777_+|calcium-binding-protein
MHSIFRWTTALLLALGVAVSAHADDTAAQIRQHAADHRLLVLGEFHGTRETPLLVRQLVDDYSRDGAPVLLALELPRAENPTLRDYLASDGGAAARQRLHGRAFWTVRDDQHDGRRSRDMLAMIEDLRALKAQGRAIELVGYDVNHSDGGSQARDDRMAAELRRLYRRLPEGACMVVLTGNVHAMLQRPADAPPEMQTQPMASALRDLDIYSVRLEALRGHFWGCMDRCKALALLERPARAPEVNTHAGREYDLWVWMPQLSVGTLVDP
>NZ_CP018756.1|WP_152027163.1|4638052_4638454_+|hypothetical-protein
MTRISVEQSMRSNFSLPIILGVALVCLAGNAAAEVKALSRANCVGFINESVTYERPQFRNFQGSAVTRHVPLGNIQPKHVFGARNNGLYSWRFYAGDGSDPERMVVHGYHTWVLGGRVFTQSTSAVDCQLSEW
>NZ_CP018756.1|WP_152027164.1|4638450_4639203_+|hypothetical-protein
MNIMKSLCSIALSLAISMSAQASQNEPAPDAVGSWLHQRAMQAAMQEAAAMGRSSASVGSYQVVKLADLDAPEEVKRRLRADIERSNSVMEAAEGDIPTQAEVLAALPRTQRSASELRQRLPQPPSRLEGSLLGPAKLIGMEPSGRLDGGQSSGLSRFYRLEGVGIVEFSENNFLAAGMQIEVIAEAQNTEVNGKPANLGKVVDGAGRTRVELAWTGDSKTYSLIATGEPGSDVERNARVLHDIAAAIVD

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Crispr_ID: NZ_CP018756_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018756_30

4636821-4636906

Orphan

Consensus_repeat	Method
ACATCCACGCATGGCGTGGATCTACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018756_30

>merge|NZ_CP018756|30|4636821-4636906|CRISPRCasFinder
ACATCCACGCATGGCGTGGATCTACTGTAGAGCCGAGCCCATGCTCGGCTGATCGCCGGAACATCCACGCATGGCGTGGATCTACT

>NZ_CP018756|30|29|4636821-4636906|CRISPRCasFinder
ACATCCACGCATGGCGTGGATCTACT	GTAGAGCCGAGCCCATGCTCGGCTGATCGCCGGA
ACATCCACGCATGGCGTGGATCTACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018756.1\|WP_079225057.1\|4644626_4645652_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP018756.1\|WP_079225025.1\|4631314_4631575_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_057497455.1\|4629698_4631306_+\|cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|238833
NZ_CP018756.1\|WP_079225044.1\|4635906_4636800_+\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP018756.1\|WP_152027163.1\|4638052_4638454_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225046.1\|4636967_4637777_+\|calcium-binding-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_079225024.1\|4628679_4629639_+\|cytochrome-c-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224537
NZ_CP018756.1\|WP_079225053.1\|4642621_4643542_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NZ_CP018756.1\|WP_079225493.1\|4640817_4642560_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP018756.1\|WP_079225040.1\|4634158_4634728_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_002808376.1\|4644245_4644461_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NZ_CP018756.1\|WP_152027164.1\|4638450_4639203_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018756.1\|WP_049468560.1\|4633071_4633290_-\|twin-transmembrane-helix-small-protein	unknown	unknown	gnl\|CDD\|378564
NZ_CP018756.1\|WP_079225049.1\|4639292_4640264_-\|bile-acid:sodium-symporter	unknown	unknown	gnl\|CDD\|372642
NZ_CP018756.1\|WP_079225055.1\|4643668_4644112_-\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NZ_CP018756.1\|WP_079225039.1\|4633347_4634064_+\|SURF1-family-protein	unknown	unknown	gnl\|CDD\|119401
NZ_CP018756.1\|WP_079225028.1\|4632175_4633051_+\|cytochrome-c-oxidase-subunit-3	unknown	unknown	gnl\|CDD\|238834
NZ_CP018756.1\|WP_079225051.1\|4640291_4640792_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|350353
NZ_CP018756.1\|WP_079225042.1\|4634738_4635902_+\|COX15/CtaA-family-protein	unknown	unknown	gnl\|CDD\|367131
NZ_CP018756.1\|WP_079225026.1\|4631571_4632162_+\|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl\|CDD\|235341

Protein	Function_ID	Function_description	E-value
NZ_CP018756.1\|WP_079225057.1\|4644626_4645652_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NZ_CP018756.1\|WP_057497455.1\|4629698_4631306_+\|cytochrome-c-oxidase-subunit-I	gnl\|CDD\|238833	cd01663, Cyt_c_Oxidase_I, Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.	0
NZ_CP018756.1\|WP_079225044.1\|4635906_4636800_+\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	3.86948e-136
NZ_CP018756.1\|WP_079225024.1\|4628679_4629639_+\|cytochrome-c-oxidase-subunit-II	gnl\|CDD\|224537	COG1622, CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion].	2.00775e-74
NZ_CP018756.1\|WP_079225053.1\|4642621_4643542_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	4.43973e-41
NZ_CP018756.1\|WP_079225493.1\|4640817_4642560_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP018756.1\|WP_079225055.1\|4643668_4644112_-\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	1.70342e-60
NZ_CP018756.1\|WP_002808376.1\|4644245_4644461_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	1.35008e-15
NZ_CP018756.1\|WP_049468560.1\|4633071_4633290_-\|twin-transmembrane-helix-small-protein	gnl\|CDD\|378564	pfam11137, DUF2909, Protein of unknown function (DUF2909). This is a family of proteins conserved in Proteobacteria of unknown function.	1.47132e-15
NZ_CP018756.1\|WP_079225049.1\|4639292_4640264_-\|bile-acid:sodium-symporter	gnl\|CDD\|372642	pfam13593, SBF_like, SBF-like CPA transporter family (DUF4137). These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.	2.54905e-113
NZ_CP018756.1\|WP_079225039.1\|4633347_4634064_+\|SURF1-family-protein	gnl\|CDD\|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	3.58378e-37
NZ_CP018756.1\|WP_079225028.1\|4632175_4633051_+\|cytochrome-c-oxidase-subunit-3	gnl\|CDD\|238834	cd01665, Cyt_c_Oxidase_III, Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. CcO catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, is believed to play a role in assembly of the multimer complex. Rhodobacter CcO subunit III stabilizes the integrity of the binuclear center in subunit I. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit III contains bound phospholipids in several crystal structures and is proposed to contain a "lipid pool." These phospholipids are believed to intrinsic constituents similar to cofactors of the enzyme.	9.52026e-92
NZ_CP018756.1\|WP_079225026.1\|4631571_4632162_+\|cytochrome-c-oxidase-assembly-protein	gnl\|CDD\|235341	PRK05089, PRK05089, cytochrome C oxidase assembly protein; Provisional.	6.8366e-83
NZ_CP018756.1\|WP_079225042.1\|4634738_4635902_+\|COX15/CtaA-family-protein	gnl\|CDD\|367131	pfam02628, COX15-CtaA, Cytochrome oxidase assembly protein. This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus subtilis. COX15 is required for cytochrome c oxidase assembly in yeast.	1.6123e-54
NZ_CP018756.1\|WP_079225051.1\|4640291_4640792_-\|tyrosine-protein-phosphatase	gnl\|CDD\|350353	cd14503, PTP-bact, bacterial tyrosine-protein phosphataseS similar to Neisseria NMA1982. This subfamily is composed of bacterial tyrosine-protein phosphatases similar to Neisseria meningitidis NMA1982, which displays phosphatase activity but whose biological function is still unknown.	1.66178e-34

>NZ_CP018756.1|WP_079225044.1|4635906_4636800_+|protoheme-IX-farnesyltransferase
MFSNYRQYWDLTKPKVVALIVFTALVGMVLAIPGVPSWEQVRAGALGFLGIWLAASAAAAINQLLDAHIDAQMARTSWRPLVVGKVKPWQVLVFASVLIVLSMAILLLWVNWITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGAMPPMLGWAAITGMQGSSDWAYSSLLVLIIFIWTPPHFWALAIFRREDYAKAKIPMLPVTHGVVHTRKQIMVYSVVLALVCVVPYLVGMSGPFYLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFHYSIVYLMALFAFLLVDHWILPWL
>NZ_CP018756.1|WP_079225042.1|4634738_4635902_+|COX15/CtaA-family-protein
MSLSARPALHRNFHRLAWFAMIMTASTIMFGAFVRLSDAGLSCPDWPTCYGQATWPQHVEETIGHPAAEIRPLETHKAWREQVHRFLAGALGIEILTLALLATRKRRFGSTAVVTACVLVAAGIPLYMMGWHGTASALALVGEAILLLAALRWSNIDLARAALLTLAVVIFQALLGMWTVTLLLKPIVVMGHLLGGMLMFALLVWMAWRATHLPITLAEAPKLKWLLRIGVAVLVTQIALGGWVSANYAALACGGGSASLDNFPRCANQWWPQHNFAEGFTLWRGIGVDYEGGVLDGASRIAIQMAHRLFAIVVAAYLLWLGLRLFRVPSMRGWASALVALLVLQVTLGILNVKLALPLEVAVAHNGVAVALLFVLVSLLARLRAPD
>NZ_CP018756.1|WP_079225040.1|4634158_4634728_+|hypothetical-protein
MNTATSPQARGSGRRTLVLLFAVFFGAMALAAVLRFTGWQPTAHRNAGQLLEPPVDLRQQPPTLANGQAYPWNPEARTWRLLVAPAGGCDAQCVTLSQGLGKVWQLFGHNADNVEILWLGTPPASIASLPALRPLAPSPALRAALPGVDDPAGLPVYVIDPNGFVIMRHAPGSDLGGLRKDMATLLKLK
>NZ_CP018756.1|WP_079225039.1|4633347_4634064_+|SURF1-family-protein
MMRQHTRVIGWLMAVLAMAAFTALGFWQLQRMHAKQAMLDAQGPATAQALPLAQALAAPGALHGVADHGRFLPGVVLLDNQMRHGRAGVKIYRPFQSDGGSVLLVDLGWRALPPDRTLPQLPAPPSPVAVRGLLAPPPAAGLALGPALSPTGEAGRWLASRLPADGLARALGLAALPDRVLRLDPALPFGDERDLDLLPNTLPPQRHLGYAVQWFGLALTVLVVALVLERRRKRPMAR
>NZ_CP018756.1|WP_049468560.1|4633071_4633290_-|twin-transmembrane-helix-small-protein
MSDSLKTLLVIAFLIVIVWNLGAGLYYLLVDRGQTKRTVNALTRRIGVSVALIVLVIVCIYMGWIKPHGIGG
>NZ_CP018756.1|WP_079225028.1|4632175_4633051_+|cytochrome-c-oxidase-subunit-3
MAQTPTDANVYFVPAQSRWPFVGSIAMMVTMVGVASWLNDASWGRWTFYIGIAMLVLTLFWWFSDVVRESQAGHYNRQVDGSFRMGMVWFIFSEVMFFGAFFGALFYTRNLGLSWLSGEGRGVMTNELLWQGYSAGWPTNGPAAIGGAFQTIPAWGLPLINTLILLTSGVTLTIAHHALKAGNRRQLLVWLGVTVLLGLGFLTLQAEEYIHAYKELNLTLGSGIYGSTFFMLTGFHGAHVLLGTIMLIVMWLRSAKGHFTRDNHFAFEAAAWYWHFVDVVWLMLFMFVYVL
>NZ_CP018756.1|WP_079225026.1|4631571_4632162_+|cytochrome-c-oxidase-assembly-protein
MSEAPATAPSRSAGLPRLIGVAVAVFLLTFSLVPLYRIACEKVFGVRLERGPGSEASTGAAAGKRTVRVEFDGGVNSRLPWSFHPEQLTMDVVPGELNEALYFARNDSANAVVGSAVPSVAPARASGFFSKTECFCFTAQTLQAGEKRDMPVRFIVDPDLPPEIRTITLSYTFYRNDALSDRLAPAATSEGAHAAP
>NZ_CP018756.1|WP_079225025.1|4631314_4631575_+|hypothetical-protein
MHNESPLPIGRVDCQSTREEQPTNGRLYNSAEQPTGRVDRWSTGEMQPTNGRLYQQRQRARRTALWVGAIAVLVYVGFILSGVIGR
>NZ_CP018756.1|WP_057497455.1|4629698_4631306_+|cytochrome-c-oxidase-subunit-I
MAHSAVGHDDHHHHQSFFERWFFSTNHKDIGTLYLGFSFIMFIIGAAMSVVIRAELAQPGLQFVKPEFFNQMTTVHALVMIFGGVMPAFVGLANWMIPLQIGAPDMALPRMNNWSFWLLPVAFSLLLLTLFLPGGAPAGGWTLYPPLSLQGGYNVAFSVFAIHVAGISSIMGAINIIATVLNMRAPGIDLLKMPIFCWAWLITAFLLIAVMPVLAGAVTMLLTDKFFGTSFFNAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGVVSEIIPTFSRKPLFGYQAMVYATAAIAFLSFIVWAHHMFTVGMPLGGEIYFMFATMLISIPTGVKVFNWVSTMWRGSLTFEAPMLWSVAFVILFTIGGFSGLMLAIVAADFQYHDTYFVVAHFHYVLVTGAVFALIAAVYYWWPKWTGRMYSEKWAKVHFWWSIVFVNLLFFPQHFLGLAGMPRRIPDYSVAFADWNLISSIGAFGMFATPFMMAAILLSSLRNGEKAEARSWEGARGLEWTLPSPAPAHTFTTPPTIRPGDLAHDDITH
>NZ_CP018756.1|WP_079225024.1|4628679_4629639_+|cytochrome-c-oxidase-subunit-II
MKQSSRWGTKCVAAVASLVAGGLVPAWAWAQAADPKPWQLNMGKGVTQTSRLAWESNNLSLIICTVIGVIVFGAMAYAIFKFRKSKGAVAATFSHNTKAEVIWTVIPVIILIVMAWPATANLIKMYDTRDAEMTVKVTGYQWMWKYEYLGENVTFTSRLDRESDRVRQSGVVPTRESHPHYLLDVDNRLVLPVDTKVRFVITSDDVIHAWWVPALGWKQDAIPGFINEAWTSIEQPGVYRGQCAELCGKDHGFMPIVVEAVSKEDFKQWLAQRKPAPAAPATPAAPAEPAAPAGEAPAAPAAPAAAEAGDTPATAASGA
>NZ_CP018756.1|WP_079225046.1|4636967_4637777_+|calcium-binding-protein
MHSIFRWTTALLLALGVAVSAHADDTAAQIRQHAADHRLLVLGEFHGTRETPLLVRQLVDDYSRDGAPVLLALELPRAENPTLRDYLASDGGAAARQRLHGRAFWTVRDDQHDGRRSRDMLAMIEDLRALKAQGRAIELVGYDVNHSDGGSQARDDRMAAELRRLYRRLPEGACMVVLTGNVHAMLQRPADAPPEMQTQPMASALRDLDIYSVRLEALRGHFWGCMDRCKALALLERPARAPEVNTHAGREYDLWVWMPQLSVGTLVDP
>NZ_CP018756.1|WP_152027163.1|4638052_4638454_+|hypothetical-protein
MTRISVEQSMRSNFSLPIILGVALVCLAGNAAAEVKALSRANCVGFINESVTYERPQFRNFQGSAVTRHVPLGNIQPKHVFGARNNGLYSWRFYAGDGSDPERMVVHGYHTWVLGGRVFTQSTSAVDCQLSEW
>NZ_CP018756.1|WP_152027164.1|4638450_4639203_+|hypothetical-protein
MNIMKSLCSIALSLAISMSAQASQNEPAPDAVGSWLHQRAMQAAMQEAAAMGRSSASVGSYQVVKLADLDAPEEVKRRLRADIERSNSVMEAAEGDIPTQAEVLAALPRTQRSASELRQRLPQPPSRLEGSLLGPAKLIGMEPSGRLDGGQSSGLSRFYRLEGVGIVEFSENNFLAAGMQIEVIAEAQNTEVNGKPANLGKVVDGAGRTRVELAWTGDSKTYSLIATGEPGSDVERNARVLHDIAAAIVD
>NZ_CP018756.1|WP_079225049.1|4639292_4640264_-|bile-acid:sodium-symporter
MTRWWSRLRPDNFTIALLCTVGLASLLPMKGAAAIVLDDVTTVAIAALFFLHGARLPRESIIGGMLHWRLHLTILACTFILFPLLGLLFKPLSGWLLTPELYMGVLFLCTLPSTVQSSIAFTSMARGNVPAAVCSASLSSILGVFLTPLLLTALAGTSGGVHDPLHAIGGIMLQLLVPFVAGHLLRPWIAGWVEKQRALLRYTDQATILLVVYSAFGEAVTEGLWSKTPLLSLFAVAVVAAVLLGIAMPLITFLARRLHFNREDEIAIVFCGSKKSLATGVPIAKVLFAGGSLGAIVLPVMIYHQIQLIVCGVIAQRYAKRAP
>NZ_CP018756.1|WP_079225051.1|4640291_4640792_-|tyrosine-protein-phosphatase
MLLRLTCLLLLSLCTTLPAWAGDTPLNEVRPGLYAGGQPSAAQLQSLAAQGVRTVIDLRQPGEDRRFDETAQAEALGLRYVRIPVAGADGLDAANVRAVHQALQQSQGPVLLHCASGNRAGAVLGLVNARYEHASPEQALQLGQRAGLTSLEAATRQRLAAPVSHP
>NZ_CP018756.1|WP_079225493.1|4640817_4642560_-|DNA-primase
MARIPDAFIDDLLARSDIVEVVGSRVPLKRQGKEYAARCPFHDERSASFTVSPTKQFYHCFGCGAHGTAISFLMNYDRLEFLDAVDELAKRAGMEVPRSENPRNAQQQDDSRELYSALDAATKFFQKNLEGSEKARTYLDGRGVDEENRARFQIGYAPDGYSGLRDALGKDERRMKLLDRAGLFSKNDRGHVYDKFRDRVMFPIFDRRGRVIAFGGRVFEKDDGPKYLNSPETALFHKGRELYGLWQVRQANQKIERLIVVEGYMDVVSLFQFGVTQAVATLGTATTPDHAELLFRNAPDVFFCFDGDAAGRRAGWKALESVLPRMKDGRQAFFLFLPDGEDPDTIVRKEGAEVFNDRLKQATPLSQFFFDELTREINLGTLDGKARLAERAKPMLAQIPDGAFGDLMKQQLAQLTGLGGGTGAAARAPMPQRAPARQIQPIAKRSLVRGAIAVLLQQPSLAMSLGGKHHFQGLRLPGVELLLELLGLVEQRPDISTGALLEHFDGREEQASLHTLAAQTMPGDEAMWTQELHDAVAQLEKQLLVQRLDELLAKQRQQGLDDTDKYELRELLKARATLRL
>NZ_CP018756.1|WP_079225053.1|4642621_4643542_-|YihY/virulence-factor-BrkB-family-protein
MVEPASPVPVNLRKYVQRLQDSFPMAVGKRFVEIDVLTQAASVSFYALLSMAPLLVLLLWLTASLYPPAQQALVEQISAAAGSSAATVAETVLKNADNQPDVGSLAGLWSTLLLFIGATAVFAQLQNALNLIFRTSGERLEGIKAWLRKRVFSFGVVLALGFLLILSMTATTMLQVAFAQLPSILPAIGYLTSLLLYAVGFAFMYHYLPDRRVAWRQAFIGGVITSALFALGRYGIGVYIATVAPGSAYGSMGALVISLVWIYYATVVFFVGALMTAVIDERLRARTHLAAAGIDPANAGPLPDRE
>NZ_CP018756.1|WP_079225055.1|4643668_4644112_-|GatB/YqeY-domain-containing-protein
MSMKQQLTDDMKAAMKAGEKHKLGVIRLINAAIKQKEVDERVELDDTAVIAVLDKMVKQRKDSVTQFVAASREDLAEIERAEIVVIEAYLPAKMGEAEIVAAIQAAIAETGATGAADMGKLMGALKPKLAGQADMGLVSKLVKQQLS
>NZ_CP018756.1|WP_002808376.1|4644245_4644461_-|30S-ribosomal-protein-S21
MPSVKVRENEPFEFALRRFKRTCEKAGVLAETRKREFYEKPTQERKRKAAAAVKRQLRRSSRDVTKRQRLY
>NZ_CP018756.1|WP_079225057.1|4644626_4645652_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MRVLGIESSCDETGVAVYDTDLAGSAALRAHAVYSQIALHAEYGGVVPELASRDHVRKLLPLVRQTLAEAGLGVGDIDGVAYTAGPGLVGALLVGAGVARSLAWALEVPAVGVHHMEGHLLAPLMEDDPPEAPFVALLVSGGHTQLVAVDAIGQYRLLGETLDDAAGEAFDKTAKLMGLPYPGGPQLARLAEQGTPGAYRFARPMTDRPGLDFSFSGLKTQVLMAWRDSDQSEQTRADIARGFEDAVVETLSIKCERALEAAGTNVIVVAGGVGANKRLRARLQQMAERLGGRACFPRPALCTDNGAMIAFAGALRLQAGQHNPPKVEVTPRWDMATLPAV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP018756_17	17.1\|2626238\|49\|NZ_CP018756\|CRISPRCasFinder	2626238-2626286	49	NZ_CP018756.1	1338749-1338797	1	0.98
NZ_CP018756_17	17.1\|2626238\|49\|NZ_CP018756\|CRISPRCasFinder	2626238-2626286	49	NZ_CP018756.1	2785397-2785445	1	0.98
NZ_CP018756_17	17.1\|2626238\|49\|NZ_CP018756\|CRISPRCasFinder	2626238-2626286	49	NZ_CP018756.1	2785583-2785631	1	0.98
NZ_CP018756_17	17.1\|2626238\|49\|NZ_CP018756\|CRISPRCasFinder	2626238-2626286	49	NZ_CP018756.1	2896874-2896922	1	0.98
NZ_CP018756_25	25.1\|3776475\|52\|NZ_CP018756\|CRISPRCasFinder	3776475-3776526	52	NZ_CP018756.1	3776513-3776564	1	0.981
NZ_CP018756_17	17.1\|2626238\|49\|NZ_CP018756\|CRISPRCasFinder	2626238-2626286	49	NZ_CP018756.1	268702-268750	2	0.959
NZ_CP018756_17	17.1\|2626238\|49\|NZ_CP018756\|CRISPRCasFinder	2626238-2626286	49	NZ_CP018756.1	2306968-2307016	2	0.959

1. spacer 17.1|2626238|49|NZ_CP018756|CRISPRCasFinder matches to position: 1338749-1338797, mismatch: 1, identity: 0.98

gaatgaattcatccacgcatggcgtggatctactggcaactgcggctgt	CRISPR spacer
gaatgaattcatccacgcatggcgtggatctactggcaacggcggctgt	Protospacer
**************************************** ********

2. spacer 17.1|2626238|49|NZ_CP018756|CRISPRCasFinder matches to position: 2785397-2785445, mismatch: 1, identity: 0.98

gaatgaattcatccacgcatggcgtggatctactggcaactgcggctgt	CRISPR spacer
gaatgaattcatccacgcatggcgtggatctactggcaacggcggctgt	Protospacer
**************************************** ********

3. spacer 17.1|2626238|49|NZ_CP018756|CRISPRCasFinder matches to position: 2785583-2785631, mismatch: 1, identity: 0.98

gaatgaattcatccacgcatggcgtggatctactggcaactgcggctgt	CRISPR spacer
gaatgaattcatccacgcatggcgtggatctactggcaacggcggctgt	Protospacer
**************************************** ********

4. spacer 17.1|2626238|49|NZ_CP018756|CRISPRCasFinder matches to position: 2896874-2896922, mismatch: 1, identity: 0.98

gaatgaattcatccacgcatggcgtggatctactggcaactgcggctgt	CRISPR spacer
gaatgaattcatccacgcatggcgtggatctactggcaacggcggctgt	Protospacer
**************************************** ********

5. spacer 25.1|3776475|52|NZ_CP018756|CRISPRCasFinder matches to position: 3776513-3776564, mismatch: 1, identity: 0.981

accggggcggtttccatgcggaccaacggtccgcacctaccggggcggtttc	CRISPR spacer
accggggcggtttccgtgcggaccaacggtccgcacctaccggggcggtttc	Protospacer
***************.************************************

6. spacer 17.1|2626238|49|NZ_CP018756|CRISPRCasFinder matches to position: 268702-268750, mismatch: 2, identity: 0.959

gaatgaattcatccacgcatggcgtggatctactggcaactgcggctgt	CRISPR spacer
gaatgaattcatccacgcatggcgtggatctactggtaacggcggctgt	Protospacer
************************************.*** ********

7. spacer 17.1|2626238|49|NZ_CP018756|CRISPRCasFinder matches to position: 2306968-2307016, mismatch: 2, identity: 0.959

gaatgaattcatccacgcatggcgtggatctactggcaactgcggctgt	CRISPR spacer
gaatgaattcatccacgcatggcgtggatctactggcaacgccggctgt	Protospacer
****************************************  *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP031166	Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence	154073-154097	2	0.92
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	35027-35051	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	142746-142770	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	382407-382431	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	426057-426081	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP015734	Arthrobacter sp. U41 plasmid unnamed2, complete sequence	166076-166100	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_MF600313	Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_1, complete sequence	123194-123218	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP029835	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed5, complete sequence	183853-183877	3	0.88
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_014035	Rhodobacter capsulatus SB 1003 plasmid pRCB133, complete sequence	55633-55657	3	0.88
NZ_CP018756_16	16.1\|2550368\|24\|NZ_CP018756\|PILER-CR	2550368-2550391	24	MH651189	Gordonia phage Schmidt, complete genome	8638-8661	4	0.833
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP015734	Arthrobacter sp. U41 plasmid unnamed2, complete sequence	73184-73208	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_009236	Burkholderia phage phiE12-2 chromosome, complete genome	20634-20658	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	CP000623	Burkholderia phage phiE202, complete genome	19630-19654	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	DQ087285	Burkholderia pseudomallei phage phi52237, complete genome	21540-21564	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	CP000624	Burkholderia phage phiE12-2, complete genome	20634-20658	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_007145	Burkholderia prophage phi52237, complete genome	21540-21564	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_009234	Burkholderia phage phiE202 chromosome, complete genome	19630-19654	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	JX681814	Burkholderia phage phiX216, complete genome	22621-22645	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	CP008753	Burkholderia phage BEK, complete genome	16526-16550	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	284916-284940	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	451304-451328	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NC_011044	Mycobacterium phage Nigel, complete genome	31434-31458	4	0.84
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	1870743-1870767	5	0.8
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	1937069-1937093	5	0.8
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP024940	Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence	230794-230818	5	0.8
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	NZ_CP016453	Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence	557745-557769	5	0.8
NZ_CP018756_16	16.2\|2550422\|25\|NZ_CP018756\|PILER-CR	2550422-2550446	25	KU160644	Arthrobacter phage Galaxy, complete genome	3971-3995	5	0.8
NZ_CP018756_20	20.1\|2821480\|28\|NZ_CP018756\|CRISPRCasFinder	2821480-2821507	28	MT774410	CrAssphage cr272_1, complete genome	53080-53107	6	0.786
NZ_CP018756_5	5.2\|1445166\|32\|NZ_CP018756\|CRISPRCasFinder	1445166-1445197	32	NZ_CP015597	Mycobacterium sp. YC-RL4 plasmid pMYC1, complete sequence	141038-141069	8	0.75
NZ_CP018756_8	8.1\|1485658\|30\|NZ_CP018756\|CRISPRCasFinder	1485658-1485687	30	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	22335-22364	8	0.733
NZ_CP018756_5	5.2\|1445166\|32\|NZ_CP018756\|CRISPRCasFinder	1445166-1445197	32	NZ_AP022319	Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence	1487545-1487576	9	0.719
NZ_CP018756_5	5.2\|1445166\|32\|NZ_CP018756\|CRISPRCasFinder	1445166-1445197	32	NZ_CP022568	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK04, complete sequence	170624-170655	10	0.688

1. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP031166 (Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence) position: , mismatch: 2, identity: 0.92

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcggtggtgacggccgt	Protospacer
************.***** ******

2. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcggcggtgaagggtgg	Protospacer
********************* .*

3. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
aggccgcttcggcggtgaaggccgc	Protospacer
 *** *******************.

4. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcggcgctaaaggccct	Protospacer
************** *.****** *

5. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttccgcggtgaaggcctc	Protospacer
********** ************ .

6. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP015734 (Arthrobacter sp. U41 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcgtcggtggtgaaggccgg	Protospacer
******* ****.***********

7. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_MF600313 (Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_1, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cgaaggcttcggcggtgaaggccgc	Protospacer
**. ********************.

8. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP029835 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed5, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcggcggcggaggccgg	Protospacer
***************.*.******

9. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_014035 (Rhodobacter capsulatus SB 1003 plasmid pRCB133, complete sequence) position: , mismatch: 3, identity: 0.88

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcggcggtgatcgccgc	Protospacer
******************  ****.

10. spacer 16.1|2550368|24|NZ_CP018756|PILER-CR matches to MH651189 (Gordonia phage Schmidt, complete genome) position: , mismatch: 4, identity: 0.833

tacggcaagccgaagggtccgggc	CRISPR spacer
ccgggcaagccgaagggtgcgggc	Protospacer
.  *************** *****

11. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP015734 (Arthrobacter sp. U41 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
tggcggcgtcggtggtgaaggccgg	Protospacer
.****** ****.***********

12. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_009236 (Burkholderia phage phiE12-2 chromosome, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

13. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to CP000623 (Burkholderia phage phiE202, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

14. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to DQ087285 (Burkholderia pseudomallei phage phi52237, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

15. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to CP000624 (Burkholderia phage phiE12-2, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

16. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_007145 (Burkholderia prophage phi52237, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

17. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_009234 (Burkholderia phage phiE202 chromosome, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

18. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to JX681814 (Burkholderia phage phiX216, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

19. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to CP008753 (Burkholderia phage BEK, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcttcgtcggtgaaggcgcc	Protospacer
*********** **********  .

20. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
cggcggcgtcggcggtgaaggagtt	Protospacer
******* *************   *

21. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
aggcggcttcggcgatgagggccgc	Protospacer
 *************.***.*****.

22. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NC_011044 (Mycobacterium phage Nigel, complete genome) position: , mismatch: 4, identity: 0.84

cggcggcttcggcggtgaaggccgt	CRISPR spacer
gggcggcgtcggcggcgaaggccgg	Protospacer
 ****** *******.********

23. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 5, identity: 0.8

cggcggcttcggcggtgaaggccgt	CRISPR spacer
atacggctttggcggtgaaggccgg	Protospacer
  .******.**************

24. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 5, identity: 0.8

cggcggcttcggcggtgaaggccgt	CRISPR spacer
atacggctttggcggtgaaggccgg	Protospacer
  .******.**************

25. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP024940 (Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence) position: , mismatch: 5, identity: 0.8

cggcggcttcggcggtgaaggccgt	CRISPR spacer
gggcggcttcggcggtgaagcgagc	Protospacer
 *******************   *.

26. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to NZ_CP016453 (Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence) position: , mismatch: 5, identity: 0.8

cggcggcttcggcggtgaaggccgt	CRISPR spacer
tggcggcttcggcggtaaaggcatg	Protospacer
.***************.*****

27. spacer 16.2|2550422|25|NZ_CP018756|PILER-CR matches to KU160644 (Arthrobacter phage Galaxy, complete genome) position: , mismatch: 5, identity: 0.8

cggcggcttcggcggtgaaggccgt	CRISPR spacer
tggcggcttcggcggtcaaggctcc	Protospacer
.*************** *****. .

28. spacer 20.1|2821480|28|NZ_CP018756|CRISPRCasFinder matches to MT774410 (CrAssphage cr272_1, complete genome) position: , mismatch: 6, identity: 0.786

gatccacccaccaccagccgcaatccgg	CRISPR spacer
gatccactcaccactagccgcaagaaag	Protospacer
*******.******.********   .*

29. spacer 5.2|1445166|32|NZ_CP018756|CRISPRCasFinder matches to NZ_CP015597 (Mycobacterium sp. YC-RL4 plasmid pMYC1, complete sequence) position: , mismatch: 8, identity: 0.75

-tatcgcgcagcgcgggcctgcccccagatcga	CRISPR spacer
ccatcat-cagcgcgggcctgccccaggatcag	Protospacer
 .***.. ***************** .****..

30. spacer 8.1|1485658|30|NZ_CP018756|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.733

aacaggccgggctggctcctggtgggtgcc	CRISPR spacer
gtgaggccgggctggctccgggtgagccgc	Protospacer
.  **************** ****.*.  *

31. spacer 5.2|1445166|32|NZ_CP018756|CRISPRCasFinder matches to NZ_AP022319 (Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence) position: , mismatch: 9, identity: 0.719

tatcgcgcagcgcgggcctgcccccagatcga	CRISPR spacer
gatcgcgcagcgcgggccggccgccgccaccg	Protospacer
 ***************** *** **.   * .

32. spacer 5.2|1445166|32|NZ_CP018756|CRISPRCasFinder matches to NZ_CP022568 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK04, complete sequence) position: , mismatch: 10, identity: 0.688

tatcgcgcagcgcgggcctgcccccagatcga	CRISPR spacer
ccctggatggcgcgggtctccccccagatcga	Protospacer
. ..* ...*******.** ************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1257532 : 1266604

Burkholderia_virus(16.67%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_079221452.1\|1257532_1258840_+	MFS transporter	Q6JIH2	Burkholderia_virus	3.2e-41	29.5
WP_192851836.1\|1258901_1259402_+	nicotinamide-nucleotide amidohydrolase family protein	B5TK85	Pseudomonas_phage	2.5e-26	50.7
WP_079221454.1\|1259437_1261120_+	2-polyprenylphenol 6-hydroxylase	E5EQ95	Micromonas_sp._RCC1109_virus	1.4e-41	29.3
WP_079221455.1\|1261351_1261987_+	transcriptional repressor LexA	A0A1W6JNS2	Morganella_phage	3.3e-15	41.8
WP_079221456.1\|1262205_1263243_+	recombinase RecA	A0A0S2MVG1	Bacillus_phage	1.5e-113	61.0
WP_079221457.1\|1263355_1263844_+	recombination regulator RecX	NA	NA	NA	NA
WP_079221458.1\|1263955_1266604_+\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	9.7e-85	39.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018756

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection