CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017717	Nonomuraea sp. ATCC 55076 chromosome, complete genome	44 crisprs	WYL,DinG,csa3,cas4,RT,DEDDh,c2c9_V-U4,cas3	6	19	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017717_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_1

169203-169332

Orphan

Consensus_repeat	Method
CCCCGAACCGGAGGGCCTCGCCTTCGGCTCGGGCTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_1

>merge|NZ_CP017717|1|169203-169332|CRISPRCasFinder
CCCCGAACCGGAGGGCCTCGCCTTCGGCTCGGGCTGTCCTTCACAAGCGCGCCCGCCCCAATCCCATTTACCGGGTGGGCCGTTGGGAGCCCACCCCGAACCGAAGGGCCTCGCCTTCGGCTCGGGCTGT

>NZ_CP017717|1|1|169203-169332|CRISPRCasFinder
CCCCGAACCGGAGGGCCTCGCCTTCGGCTCGGGCTGT	CCTTCACAAGCGCGCCCGCCCCAATCCCATTTACCGGGTGGGCCGTTGGGAGCCCA
CCCCGAACCGAAGGGCCTCGCCTTCGGCTCGGGCTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080036296.1\|169839_170151_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036291.1\|162731_164051_-\|class-I-SAM-dependent-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|225174
NZ_CP017717.1\|WP_155126321.1\|177393_178221_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197314
NZ_CP017717.1\|WP_080036301.1\|176406_177372_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP017717.1\|WP_080046402.1\|175383_176322_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NZ_CP017717.1\|WP_155126312.1\|162013_162616_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155126309.1\|161083_161716_+\|DUF2587-domain-containing-protein	unknown	unknown	gnl\|CDD\|378489
NZ_CP017717.1\|WP_080036292.1\|164049_165669_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226849
NZ_CP017717.1\|WP_080036294.1\|167826_168492_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_CP017717.1\|WP_080046400.1\|159160_159589_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221
NZ_CP017717.1\|WP_080036297.1\|170259_171393_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP017717.1\|WP_080036295.1\|168493_169153_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_CP017717.1\|WP_155126315.1\|169480_169714_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036298.1\|171489_173313_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214807
NZ_CP017717.1\|WP_155126318.1\|174394_175363_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349398
NZ_CP017717.1\|WP_080046401.1\|159671_160568_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320695
NZ_CP017717.1\|WP_080036293.1\|165671_167723_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP017717.1\|WP_080036288.1\|160767_161028_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|311556
NZ_CP017717.1\|WP_155126324.1\|178259_178754_-\|G/U-mismatch-specific-DNA-glycosylase	unknown	unknown	gnl\|CDD\|381679
NZ_CP017717.1\|WP_080036299.1\|173417_173963_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226426

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080036291.1\|162731_164051_-\|class-I-SAM-dependent-RNA-methyltransferase	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	1.23549e-103
NZ_CP017717.1\|WP_155126321.1\|177393_178221_-\|hypothetical-protein	gnl\|CDD\|197314	cd09080, TDP2, Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains. Human TDP2, also known as TTRAP (TRAF/TNFR-associated factors, and tumor necrosis factor receptor/TNFR-associated protein), is a 5'-tyrosyl DNA phosphodiesterase. It is required for the efficient repair of topoisomerase II-induced DNA double strand breaks. The topoisomerase is covalently linked by a phosphotyrosyl bond to the 5'-terminus of the break. TDP2 cleaves the DNA 5'-phosphodiester bond and restores 5'-phosphate termini, needed for subsequent DNA ligation, and hence repair of the break. TDP2 and 3'-tyrosyl DNA phosphodiesterase (TDP1) are complementary activities; together, they allow cells to remove trapped topoisomerase from both 3'- and 5'-DNA termini. TTRAP has been reported as being involved in apoptosis, embryonic development, and transcriptional regulation, and it may inhibit the activation of nuclear factor-kB. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	5.76115e-06
NZ_CP017717.1\|WP_080036301.1\|176406_177372_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	5.85475e-116
NZ_CP017717.1\|WP_080046402.1\|175383_176322_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.69809e-118
NZ_CP017717.1\|WP_155126309.1\|161083_161716_+\|DUF2587-domain-containing-protein	gnl\|CDD\|378489	pfam10759, DUF2587, Protein of unknown function (DUF2587). This is a bacterial family of proteins with no known function.	1.5143e-26
NZ_CP017717.1\|WP_080036292.1\|164049_165669_+\|hypothetical-protein	gnl\|CDD\|226849	COG4425, COG4425, Predicted membrane protein [Function unknown].	1.66819e-174
NZ_CP017717.1\|WP_080036294.1\|167826_168492_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	1.76505e-37
NZ_CP017717.1\|WP_080046400.1\|159160_159589_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	3.59699e-28
NZ_CP017717.1\|WP_080036297.1\|170259_171393_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.19426e-28
NZ_CP017717.1\|WP_080036295.1\|168493_169153_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	1.87741e-44
NZ_CP017717.1\|WP_080036298.1\|171489_173313_-\|hypothetical-protein	gnl\|CDD\|214807	smart00758, PA14, domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins.	1.66381e-26
NZ_CP017717.1\|WP_155126318.1\|174394_175363_+\|hypothetical-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	1.62074e-50
NZ_CP017717.1\|WP_080046401.1\|159671_160568_-\|M48-family-metalloprotease	gnl\|CDD\|320695	cd07336, M48B_HtpX_like, Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase. This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.	1.21868e-122
NZ_CP017717.1\|WP_080036293.1\|165671_167723_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.24523e-34
NZ_CP017717.1\|WP_080036288.1\|160767_161028_+\|DoxX-family-protein	gnl\|CDD\|311556	pfam07681, DoxX, DoxX. These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.	8.02591e-06
NZ_CP017717.1\|WP_155126324.1\|178259_178754_-\|G/U-mismatch-specific-DNA-glycosylase	gnl\|CDD\|381679	cd10028, UDG-F2_TDG_MUG, Uracil DNA glycosylase family 2, includes thymine DNA glycosylase, mismatch-specific uracil DNA glycosylase and similar proteins. Uracil DNA glycosylase family 2 consists of thymine DNA glycosylase (TDG), which removes uracil and thymine from G:U and G:T mismatches in double-stranded DNA. It includes mismatch-specific uracil DNA glycosylase (MUG), the prokaryotic homolog of TDG. Escherichia coli MUG is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other..	7.79589e-78
NZ_CP017717.1\|WP_080036299.1\|173417_173963_-\|AAA-family-ATPase	gnl\|CDD\|226426	COG3911, COG3911, Predicted ATPase [General function prediction only].	2.10076e-35

>NZ_CP017717.1|WP_080036295.1|168493_169153_+|TrkA-family-potassium-uptake-protein
MRVAIAGAGAVGRSIAAELLENGHEVLLIDNDPRAIKIDSVPRAEWLLADACEIASLDEAGLNNCHVVVASSGDDKVNLVVSLLAKTEYGVPRVVARINHPNNEWLFNESWGVDVAVSTPRLLSALVEEAVSVGDLVRLMTFRQGQANLVELTLAEDAPVVGQRAGSVPWPVDAALVAILREGRVLVPTADDPLEAGDELLFVANQEVEQELAHLLSQH
>NZ_CP017717.1|WP_080036294.1|167826_168492_+|TrkA-family-potassium-uptake-protein
MHIVIMGCGRVGSTLAHILEDSGHSVAIIDRDPQAFRRLRAGFRGRRVTGVGFDRDVLTEAGVESAAAFVAVSSGDNSNIISARVARETFGVDNVVARIYDPRRAEVYQRLGIPTVATVRWTADQIMRRILPEGAEPLWRDPTGTVVLAEVTVHGSWIGTRVTDLETRARARAAFINRMGEAVTISDDTVVQEGDVLHVIAAENDMDRINKVLAAAPEEDE
>NZ_CP017717.1|WP_080036293.1|165671_167723_-|APC-family-permease
MAKVTDLVKRLLVGRALRSGQLHEQLLPKRIALPVFASDALSSVAYAPQEILVILSLAGVSFYSFSPWVAIAVVVVMLTVVASYRQNVHAYPSGGGDYEVATTNLGKNAGLTVASALMVDYVLTVAVSVANGVDYVGATIPFVGQHKPAVAIVIVILLTVVNLRGIRESGAAFAIPTYAFMIAVLGLIAWGGFRLLVLHEDLEAPSAHFTIEPEQHNLTAFAAAFLVLRAFSSGCAALTGVEAISNGVPAFRKPKSKNAATTLLMMGLVAITMFSGIIALGLASGVKVAEPSVVAEDLLMPGGTPVGPGYYQQPIIAQVADAVFGGGSLPFIVISAVTALILFLAANTAFNGFPVLGSILAQDRYLPRQLHTRGDRLAFSNGIIILALGACLLLWGFQADVSRLLNLYIVGVFVSFTLSQTGMVIHWTRHLKTETDPKVRHQMHRSRVINFFGGVMTGLVLIVVLLTKFLVGAWIVVIAMPILFLMMKGIRRHYDKVAAELELTEDYEPAMLPARNHTIVLVSKIHKPTMRALAYARATRPSTLEAVTVGVEGDEARKLQEEWERRGIPVPLKMLDSPYREITQPILDYVKAIRRRSPRDVVTVFIPEYVVGHWWEHLLHNQSALRLKARLLFKPGVMVTSVPWQLHSSDRLLGRPEPFAPGAVRRPPSQQAAKPEQLADKRP
>NZ_CP017717.1|WP_080036292.1|164049_165669_+|hypothetical-protein
MERVVRRRLGFGGTLLATLFACASLTPSLLPRTWLYQGVMGAVTGILGYAVGAAAGALCRTVIRLPERGRRAAWQVMLGGCAALAVVALWYSLDWQRDLRALMGMDTRIEWFPPVILAVAAVLFAAALLAARLVRLGGRKLITWLDRYVPAYLGHALGVVVVALLVGVFANDVLFNGFVARMSDISSVANEGTHPGVRRPVSAFVSGGPRSLVSWESLGREGRRFTGTAATPARLRAFSGRPAVEPIRVYIGLDSAASPAAQAALAVRELERTGAFGRPVLAVLGTTGTGWVDPHIADTLEYMYNGRSAMVAMQYSYLPSWVSFLVDREKAAAAGRALFEAVRARWARLPAGARPKLLLSGESLGSYELEQAFRGLADLVARADGAVFVGPPNANPIWHRLTSGRDRGSPVWRPVFQDGRTARFAQHPADLHRPGGPWPRPRVVYLQNASDPVVWWSPRLIYHRPSWLEGARGPGVNPQMNWFPLVTFWQVLVDMTSALDVPPGHGHRYGANIVDGWAAVAAPPGWSPNDTWRLRTLLR
>NZ_CP017717.1|WP_080036291.1|162731_164051_-|class-I-SAM-dependent-RNA-methyltransferase
MNTQRNGSSPISGHPGRGTKVSDVEQASLELTVGPVAHGGWCVARHEGRVVFVRHALPGERVIADVTEETSRFLRADAVEILEASPDRVVPPCPYAGPGRCGGCDWQHATLEAQRRLKGQVVAEQLRRLAGIEREVVVEEVPGAKDGLGWRTRVQFAATPAGELGFRRHRSHDIEVVDACLIAHPEVEAAGVEEHTWQGAAGVEVIASSGGDRAVVVRPRPRRSVTVPDLEAPASILLDQGKGRTVPRRGSGVLHEQVGDREFRVAGSGFWQVHPGAAETLLDAVLAYAAPEPGEWALDLYCGVGLFAAGLAEIVGPEGAVFGLESEAAAVRDARANLRDLPQARIERGRVEEALDRFQIERADIVVVDPPRAGLGRDVVERIASLDALRIVYVSCDPATLARDLAWFRDHGYAMSDLRAFDAFPMTHHVECVALLARP
>NZ_CP017717.1|WP_155126312.1|162013_162616_+|hypothetical-protein
MTPTEARTYINEALRCLESTWGRHLKKAGLPYEPVKVRYVTSLPKNYCGSEDGETIESSEVWYCDWDRTLSFKIGKSWLLGPPDLDLFNTTAVMYGYHVQKLAGLYDASEDLRAGSKAEHLEQRRRMYQQVECLGAAFMKSVWPLPGKTARDWKRVESSYHGDTAEYGKAASIKQWVKAGFRTADPASCNTWVAPSSKVS
>NZ_CP017717.1|WP_155126309.1|161083_161716_+|DUF2587-domain-containing-protein
MPMNSAHQGEPRIRRSPSGLLVVEHGEQAAGGGASGASQLPPSEPSQPSPPEPSARKNAWPSAELAAMARQDKLVRLGVMIRQLCAELREMTLDENAQARLAVLYDRIAEEIAGILPPELRQELHRLRPSLDARPTRAELRVVHAQLLGWLEGLSHGVQVALSLHRANLVQQYQALRSGTSGGGTSGARGPAATPQAGSSPPGLHSNAYL
>NZ_CP017717.1|WP_080036288.1|160767_161028_+|DoxX-family-protein
MDIGLLILRVALGALPAAHGAQKLFGWFGGHGLAGTAGFFDSVGYRPGRRLAAATAAWGWRQHVRQHETGTAPQRSGTDLTHAATR
>NZ_CP017717.1|WP_080046401.1|159671_160568_-|M48-family-metalloprotease
MRRLANTLKTAALLGLLTAIVLTLGYWIGGQAGLLAALALSLGLNVATWLFSDRLALRAMRARPLSRSEAPGVHAMVAGLAAAAGQPMPRLYVSPVRQPNAFATGRGPQHAAVCVTEGLLDLLSPRELRAVLGHELAHVHNRDILLSSVAATLAGGLTMLADLAWLLPLGPDGDDGDESSPGPLGWLAMLVLGSLAATLIQLAVSRTREFAADDEGAALTGDPLSLADALEKIHAWTRRLPLPATGDVPAAAHLMIANPLSGHGLAALFSTHPPLYQRVARLHMLSAAASPNVRKVYN
>NZ_CP017717.1|WP_080046400.1|159160_159589_-|Hsp20/alpha-crystallin-family-protein
MLLTSIDPLLQEAERQFGQLAAIAGRDQAMPMDGLRRHDDLLLRFDIPGVDPDSIEVSVDRGVLSVSATREEEHGEDERLFVQERPMGSFTRRVYLPEHLDTEHVEAAYDNGVLTLRIPTVETAKPRTVEIRTGEQAKAING
>NZ_CP017717.1|WP_155126315.1|169480_169714_-|hypothetical-protein
MTTASGWVRHLSWNERRAFALELVEALSGPAAVDVGVAAREVVAGWRATARIKADPLEYAKAREATSGDFGEVQVSA
>NZ_CP017717.1|WP_080036296.1|169839_170151_-|hypothetical-protein
MLVAVALAGGLFTATSGCAAEPPSLRERLIQDLKRNPQYKDYSDKQLECVADVSIKYTKPEAIEQVMKGETPADSGWKDGVDGRAVTRDFMACTGPIVPSPTN
>NZ_CP017717.1|WP_080036297.1|170259_171393_-|Fic-family-protein
MLYSTPRLDKADLQALEDIERMRHDLRLHLRPQARWTKQLRRSLTARAIVGSNTIEGYAASVDDVEALMAGEEPLESSESTRRELEGYQRAMTYIQGLADAGEQFRYDLGLLNGLHFMIQEPHTNKRPGRLRQGPVYVTSPDDPAFPAYTGPDPESVPGLMNELVEWLNEGDLDAPVHVRASMAHLNLVKIHPWADGNGRMSRALSTLVFAREAVLPAEFSSIEEWLGRGQNTYAYYQILQEVGGPVWSPERDTHPWITFCLRAHHFQAQQAKRRVDLLSRAWRELSTAMADAGLDDRTVFALLPAFWSSRVRRTVYQQDADLSPQQAVRDIRELCRRGWLTPQGQARGRYYVAGPSMQPVLESVQQSTKPYVDPYR
>NZ_CP017717.1|WP_080036298.1|171489_173313_-|hypothetical-protein
MTALARRAARTVLTIGLATATIWTAGAPSQAATSATIAAATPAATSAITPAAVSVDFTKPIRALSPTDYGIGITGYGSGSYITNDPRHRELLTDLAPGRMRIELHYERPGDHTSPIVCGGYKCDTTVTGDAWIAAIRDLGAEPVVILQVDGRQSAEVNRADAVALYRHFAASGTPVRRFILGNELNCACTPEKPEMPATEYSARFNLIADALNAEDPQVTVGGPATAWNDHSYIRTFLEGSGDRVDFLDYHDYGNGSETVSDADLLTTVVRAYETDLKAVSALAESVLGRRIDIQIGEFNSDYDDPGGARTLTHFNTLWGAAALGRILHAGAAAYQYGDKNGQLGLTSTNGEGGIPRSEPLPIYHGIGMFTGEGRFRPFGTTMVEATADTPLLHTFASDGAKNVVLVNTATEPLETTLTFTGLTAGTAAAWQSTATEWTPHHTATTPITAGKTTLTLPARSVTTLVIQEQGLSATYFDNADLTAPKLTRVDPGVNFDWGSGTPDPAIAPDTFSVRWTGKVIADRAETYTFITTSDDGVRLWVDGTLVVDAWTDHSKRDDSGQIALTAGPHAIRMEFYDSGYDAIAQLHWSSPSIQRQLVPAAKLLTG
>NZ_CP017717.1|WP_080036299.1|173417_173963_-|AAA-family-ATPase
MKRYVLTGTPGAGKTAILRRLELDGHTVVEEAATDVIALRHAEGDEEPWASPSFVTDVVTLQRRRQERAAALPGDVQFYDRSPLCTYALATYLGHPVPDALTHELERIKEQRVYERTVLFVCSPGFVTPTAARRITYEEALRFERIHRDTYTAFGYDCVPIPTGPLTDRVATVAARLGTAP
>NZ_CP017717.1|WP_155126318.1|174394_175363_+|hypothetical-protein
MTNRYRSRQNAEPSSVYRNWRKPPMRRPLGVLAAAASLAAIAAPLSATQAAAASEAARCRVSVAKPQVSDTLKIETWAARRGCSNSALLRIRILRAVPGKDPVVKSGASRKGRLTLTLACEPGTYYATATDYRGRPVKSRAVRLTCTPGSGTPTPSPTATSPTPSPTPTSPAPSPSSPAPSPTTSAPSGGGSVGTAEENEVVRLVNEERAKGGCSALAHDPQLRTAAFGHSADMAAKGYFSHTSQDGRSFMDRIRAAGFTGGSGWAENIAKGQRTPAQVMQSWMNSSGHRANIMNCKYNLIGVGVAKDSSGTLYWTQDFAAR
>NZ_CP017717.1|WP_080046402.1|175383_176322_-|NADP-dependent-oxidoreductase
MRAISQDVLGGPEVLKEIRLPKPEAGLSELLVRVHAAGLNPTDWKHRGVPGLFLGEPPFVLGWDVSGVVEATGPGVTLFKPGDEVFGMLPYPHGAGSHAEYVTGPARAFARKPATLDHVQAGALPLAALTAWQALVDTARIEPGQRVLIHAAAGGVGHLAVQIAKTRGAYVIGTASAPKHDFVRSVGADEVIDYRATDVTEAVRDADVVLDAQGSEHARRSLRSLRPGGLLVSLRLDPGMTALTEEAARLGVRAEVMLVEADHAGMRAIAELAADGRLRAEIAGTFELADAAKAHAMGDTGRTAGKLVLTVE
>NZ_CP017717.1|WP_080036301.1|176406_177372_+|helix-turn-helix-domain-containing-protein
MHRVVVLALDGVYPFELGIPQRVFGIAHDLYEVVTCTVDGRPVRTSADFTIMVDRGPEALAEADTVVIPPYSSAPDTAELPAPVADALALIPAGARIVSICTGAFTLAAAGLLDGRPATTHWTLAPRFRELFPRVALDPNVLFVDNGDVLTSAGAASGVDVCLHLVRKDHGSQVANHVARKCVVPPWRDGGQAQYIEQPVPEPSSAGTAATREWALARLDEPLTLTDLARHARMSLRTFARRFRDEVGMSPGRWLIQQRVARARELLESSDLPVEVIAGRVGFGTAASLRQHMHAVIGVSPQSYRNTFQTARAPAQAGSRG
>NZ_CP017717.1|WP_155126321.1|177393_178221_-|hypothetical-protein
MIGHLVLAGLLSLSCLPAHAGPPHEARTAPLQAARPASLHVMTWNVCAGTYSSCPLFRRTTAELAWHVAVLATQADVIFLQEFCSGADADLERELEARTGRAWSVGSAGFAHPDGSPYQCAPDRNGRARGVQSVTLAVAGQDVRFETHALTTPPWGLRRNAICTAGRTFCTAHLSSGSPYDDRQKGAPYRHKQLGELLKLARGVVGGDLNLVPRAASAAYRGRDECDPRDRWTYVTKKRKIDYVFAGPGRVRHCFVDHARKRWSDHVPVHAWVAR
>NZ_CP017717.1|WP_155126324.1|178259_178754_-|G/U-mismatch-specific-DNA-glycosylase
MIDDVLGPSLDVLFCGINPGLMSEATGHHFARPGNRFWPALHLSGFTPRLLSPAEQHLLPSYGLGITNIVPRASAKASELTREELEAGGAALAAKVASLAPKVLAVLGISAYRTAFARPKAVIGPQPERVGGVRVWVLPNPSGLNAHWTVATIAEEMGRLRSSL

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Crispr_ID: NZ_CP017717_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_2

328342-328437

Orphan

Consensus_repeat	Method
ACCAGGCTCCTGGCGTGGCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_2

>merge|NZ_CP017717|2|328342-328437|CRISPRCasFinder
ACCAGGCTCCTGGCGTGGCGGGCCTGGGCGTTCACACCAGGCTCCTGGCGGGACGGACGGCCTGAGGGCTCACACCAGGCTCCTGGCGTGGCGGGC

>NZ_CP017717|2|2|328342-328437|CRISPRCasFinder
ACCAGGCTCCTGGCGTGGCGGGC	CTGGGCGTTCACACCAGGCTCCTGGCGGGACGGACGGCCTGAGGGCTCAC
ACCAGGCTCCTGGCGTGGCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046419.1\|317452_318955_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277324
NZ_CP017717.1\|WP_080046420.1\|324026_324599_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP017717.1\|WP_080036423.1\|336897_339249_+\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376913
NZ_CP017717.1\|WP_080036418.1\|330807_332418_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377939
NZ_CP017717.1\|WP_080036421.1\|335607_336432_+\|molybdopterin-dehydrogenase	unknown	unknown	gnl\|CDD\|224238
NZ_CP017717.1\|WP_080036420.1\|334195_335611_+\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
NZ_CP017717.1\|WP_080036410.1\|315081_316770_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP017717.1\|WP_080036422.1\|336265_336901_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP017717.1\|WP_080036408.1\|313051_314548_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223651
NZ_CP017717.1\|WP_080036409.1\|314510_315050_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_080036414.1\|321950_322775_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225758
NZ_CP017717.1\|WP_080036424.1\|339257_340277_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275380
NZ_CP017717.1\|WP_080036411.1\|316907_317324_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036412.1\|319013_320582_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	unknown	unknown	gnl\|CDD\|237876
NZ_CP017717.1\|WP_080036419.1\|332429_332642_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|379097
NZ_CP017717.1\|WP_080036425.1\|340373_340799_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036413.1\|320603_321863_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP017717.1\|WP_080046421.1\|332827_334045_+\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
NZ_CP017717.1\|WP_080036417.1\|329750_330689_-\|DUF2877-domain-containing-protein	unknown	unknown	gnl\|CDD\|378658
NZ_CP017717.1\|WP_080036415.1\|322771_323971_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080046419.1\|317452_318955_+\|metallophosphoesterase	gnl\|CDD\|277324	cd07378, MPP_ACP5, Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain. Acid phosphatase 5 (ACP5) removes the mannose 6-phosphate recognition marker from lysosomal proteins. The exact site of dephosphorylation is not clear. Evidence suggests dephosphorylation may take place in a prelysosomal compartment as well as in the lysosome. ACP5 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.57697e-07
NZ_CP017717.1\|WP_080046420.1\|324026_324599_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.0336e-10
NZ_CP017717.1\|WP_080036423.1\|336897_339249_+\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	0
NZ_CP017717.1\|WP_080036418.1\|330807_332418_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	3.24254e-39
NZ_CP017717.1\|WP_080036421.1\|335607_336432_+\|molybdopterin-dehydrogenase	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	6.22522e-48
NZ_CP017717.1\|WP_080036420.1\|334195_335611_+\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	4.30958e-98
NZ_CP017717.1\|WP_080036410.1\|315081_316770_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.24875e-61
NZ_CP017717.1\|WP_080036422.1\|336265_336901_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.66666e-74
NZ_CP017717.1\|WP_080036408.1\|313051_314548_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	4.01147e-113
NZ_CP017717.1\|WP_080036414.1\|321950_322775_-\|MOSC-domain-containing-protein	gnl\|CDD\|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	7.34051e-55
NZ_CP017717.1\|WP_080036424.1\|339257_340277_+\|hypothetical-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	7.82987e-40
NZ_CP017717.1\|WP_080036409.1\|314510_315050_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.13623e-07
NZ_CP017717.1\|WP_080036412.1\|319013_320582_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	gnl\|CDD\|237876	PRK14975, PRK14975, bifunctional 3'-5' exonuclease/DNA polymerase; Provisional.	0
NZ_CP017717.1\|WP_080036419.1\|332429_332642_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|379097	pfam13275, S4_2, S4 domain. The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	3.9057e-27
NZ_CP017717.1\|WP_080036413.1\|320603_321863_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.12406e-23
NZ_CP017717.1\|WP_080046421.1\|332827_334045_+\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	1.5799e-87
NZ_CP017717.1\|WP_080036417.1\|329750_330689_-\|DUF2877-domain-containing-protein	gnl\|CDD\|378658	pfam11392, DUF2877, Protein of unknown function (DUF2877). This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.	5.27033e-29
NZ_CP017717.1\|WP_080036415.1\|322771_323971_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	4.73429e-77

>NZ_CP017717.1|WP_080046420.1|324026_324599_-|TetR/AcrR-family-transcriptional-regulator
MARPRKFEEDRAVEAAMRAFWSAGYEATSTQDLCAATGLGRSSIYNTFASKRELFERALRHYTDERNANLAELMEGELPVKEKVRTVLWWAVEPDPDDPAGCLVVNSLVELGPRDPEIAELLRRDQDKRLQIMTAALEAARARGELDAGKDPLALARFVAATVSGLRVAARGGADRAMLESIANTALGVF
>NZ_CP017717.1|WP_080036415.1|322771_323971_-|MFS-transporter
MPLAVYILGLSIFAQGTSELMLAGLLPEMARDLGVSVPDAGLLISAFAIGMLVGAPVLAVLTLRWPRRTVLLAFLALFALSHVAGALTSSYGVLFATRVVGAFVYAGFWAVAASTAIGLVPVNARAKAMSVLAGGLTVATVIGLSAGTVIGQHLGWRAAFWSVAALTALAGLGVFATIPGGRPDRSGTPRVSDELRALARPALWLAYGTTALTTGALLSTFSYLSPLLTDVTGLDPAWVPAVLGLYGVGALIGITVGGRIADARPYPLLYAGVTGLVLTSAALAASASVALLAIPLIFLLGAFGFGTNPALNARPFALAKNAPTLAAGMNVASFNVGITVGPWVGGLAIGAGLGYASVAWIGAAIGVAGLAAVALGASLHRRSEIAGETRETGEVRSAV
>NZ_CP017717.1|WP_080036414.1|321950_322775_-|MOSC-domain-containing-protein
MKLAGISFYPVKSTAGHEVTEAEVQPWGLAGDRRYLITDERGAVLTARQEPRLLACVPVLDGGVLTLTGPHAEPLTVVPTAAMSTVHMGGVAVEVTDCGDAAAAWLSGLAGRPVRLKWLDDPTRRPVNPLYGRPDDRVSLADAFPLLLTTTASLARLNDWIAETALELGEEPRALPMRRFRPNVVIDGVAEPFAEDEWKRLRIGEVEFRVTKGCDRCVLTTVDTETYRKGKEPLRTLARHRKREGKVWFGINLIPDLVPGTFGRIAQGDPVVLL
>NZ_CP017717.1|WP_080036413.1|320603_321863_-|MFS-transporter
MTSTPTKPAVSSPDRIQRVQRRTLAVLSAAQIVGGVGVAVGLALSSVVVDELSRSTVISGFAGTATVLGAALLALPAAKASGRGGRRAGLSLAYTAALTGCVISVLAISLRNWPLLLAGLVLVGGGSAGSLAARYSATDLSPKDRSARHLSLVVWASTIGSVAGPNLAEPADRIGRSLGMAEKAGPFAFAALAFALAVVIVLVLLRPDPLILARAGTRTEDPGRNRTIRTAWHTLRTTPTARHALVMIAVSHTAMVSVMSMTPVKLHHDGSNLDVIGLVISLHIAGMYVLSPLVGWLADKAGKVPVLVLGSALLLSAAALAGTAGHRVWQVTAALVLLGLGWSCGLVAGSALVTESVPIERRPAVQGLSDLLMNVCGATGTIVAGAIVGLLGYGMLGLMVGIMVALSGLWLTAVWRRTS
>NZ_CP017717.1|WP_080036412.1|319013_320582_+|bifunctional-3'-5'-exonuclease/DNA-polymerase
MYVVVAGETVLPVGGTPRRPADLAEAVRELEAAEGPRWVWADARETYPPLLERGVRVARCHDLALTEGLLLAYEGRYGEPRSARAAHARLHGLPVPDEQPSAPGTLFAPEPLGAEAVAEVLADQLRRIAALPEPGRFRLLVAAESAGALVAAEMSHEGMPWRRDVHDALLTELLGPRPVHGMRPARLQALADEVAAAFGHPVNPDSVQQLVKAFKGAGVALKTTRQWELKQIEHPAVAPLLAYKELARLFSAHGWAWADQWVRGGRFRPEYVVGGVVSGRWATNGGGALQIPKVMRKVVVADDGWLLVVADAAQLEPRVLAAMAGDGGLARAAGEIDLYSALAQSFGGERANAKIAMLSAMYGGTSGDASKLLAVMRQRFPKAYQFVEDAAKAGEEGRIVRSWLGRTSPPPSERWKELVSGPEGGRAARDRGRFTRNFVVQGTAAEWALALLAVLRGRLPEPARLVFFQHDEVMVHCPAELADEVIAAVTGAAAEASRLLFGRTPVRFPMEAVAVKSYADAK
>NZ_CP017717.1|WP_080046419.1|317452_318955_+|metallophosphoesterase
MVEVAAERGKQVSSRVSEEGAGWACVQPGTFAQLRPNKQGFTWLNVRTLWLSRNEILAGLFGDPSGEVRARWVESQEARGIDPEFRIKPAVGGNFSFLLLGDTGEGDASQYAVVPGMLKLGEGTSFAIIASDVIYPTGSGNEYGDKFFRPYQDYDAPIYAIPGNHDWYDGLGGFMRVFCDAPPLKPKPDRGLRGLLWRKPETIDEAKLAEARKLRGRPSQQATGQAAQPGSYWVIESDSLLVVGVDTGIRNVIDKGQTAWLRRVSLDPRPKILVTGKPIYTGNAYKPSPLEGGGTIDDIVRDPAHRYVAAIGGDVHNYQRYPVKVGDRVIQYIVSGGGGAFMHATHTIERVDVGGVHEDDFRCYPLRGDSLSFYSQLYAKRLRMKWLCLTPTEALCIMSQHIKNEPVRTPTGPVKITMRMRWAARLLGAWPWPLRLPVDKVFHRFLSELSDWDTPPFFKQFLHATVTPEELTLRCFAATGCLAQELDPPMEDEVRISLDV
>NZ_CP017717.1|WP_080036411.1|316907_317324_-|hypothetical-protein
MTRNSPDDATRKGTSAVDAIEGLLAFAASRPRWAASAAINSASEAIARSRALAAQSPGEHLPLLARCLNTTARLMLARGRATEALPLAQEAVALSRSIGGASLAVSLRRLAAAQEALQRFGDAAATLAEADRLPPPPG
>NZ_CP017717.1|WP_080036410.1|315081_316770_+|FAD-binding-oxidoreductase
MSWSGWGDPAKARELPEPVLALLRDLLGVRAPGTPAAALEEVALPPVVLPEPVLNALAKVVGEQNVRTGHEDRVRHTRGKSTPDLLRMRAGDGSAAPDAVVLPGSHEEVAELLRVCSRERVAVVPFGGGTSVVGGLAPDRTGFAGVVALDLGRLDRLISVDEESMVAAFEPGVRAPDAERLLAARGLTLGHFPQSFEYATLGGFAAARSSGQASAGYGRFDDMVVGLTLATPAGTLELGRAPKSAAGPDLRQLVLGSEGAFGVITALRLRVRRAPAERRYEGWRFATFAQGSAAVRALAQEGPLPTVLRLSDETETMIGLAKPDEIGSDGARGPDGAGGSGAAAGSDGAGGSGAEGSGGAGSGGAGSGGAVGSGCLLVAGYEGVRVGSRHAAASALLARMGGEPLGPEPGEAWERGRFSAPYLRDSLLAAGATVETLETAGFWASLPRLYDAVRLALLGALGSPLVMCHISHVYETGASLYFTVVTPQDADPVAQWERAKAAVNAAVVEAGGTITHHHGVGRDHLDAYAREIGPVGTGVLRAVKAELDPAGILNPGVLVPRA
>NZ_CP017717.1|WP_080036409.1|314510_315050_-|helix-turn-helix-transcriptional-regulator
MTSIRHNDGVLDAARDCVLAYGVRRTTLTDVARRAGVSRMTIYRRWPDVRTLVADLMTREWVRVVAGLDLSDPVRAVVAGVRGLREHPLWRKIVEADPELLVPYLLDRRGASHDAILEVLEPAVGDPARARAVLLVAQSFLLSAPTMLDPVTMDELDAELTALLEAYLGQLAERRQTLP
>NZ_CP017717.1|WP_080036408.1|313051_314548_-|FAD-dependent-oxidoreductase
MDSSLNAARRSRELRRVAEERADVLVVGLGATGAGAALDAVSRGLSVAAIDAHDLAFGTSRWSSKMVHGGLRYLAKGQVGVAYESAVERGILLRRTAPHLVKAHPYLLPLTPAVSRRQAALVMSGYRLGDGLRAAARTPRRLLPGPTRLNAARAHTLAPILRTDGLRGALLSWDGRLLDDARLVVALARTAAARGARVLTRCRALRLTGQGAQARDELTGEEFTIRAKVVINATGVWAGTLDPQVKLRPSRGSHLVLEPGTLPGLIAGMHVPIPGESNRFALVLPQPDGRVYVGLTDEPVDGPVPDVPEVPPEDVRTLLEVLNGVLEVPVTEEAVAGAYAGLRPLLAADGRTADLSREHAVLSEGGVVTVVGGKLTTYRRMAEDAVDRAVSSAKLRAGRCRTRRIALVGAGPRPSGVPLRLAERYGSEAAAVHELVLGHPEEVGLGFTQGELLWSVLHEGALDEGDLLDRRTRIGLVKRDRDRALPATRDVLDRFSRA
>NZ_CP017717.1|WP_080036417.1|329750_330689_-|DUF2877-domain-containing-protein
MGGPVTVSTSARRARVRVTGAASTAVRPVLEAQRRPARVLAAFPAGVYLEVRTEAEPSVIAVITGEATRLPNSVLLAGPLPAVTVGDDASVGDRVIDLGPLSLSVRRWWDPAPPLGRLDPALLDDGLPKDPPGAGLAGNGAVDMLASSCAKGWLLGAVTAAEQLVGLGPGLTPSGDDVLAGLLVTLRHLGVAAGCGRAVWLADWLAATVTFDARTRTTPISATLLHCAARGEASPEVIAVLRGVAGRQPLEPALRRQALEPALRRPALEPARRQALESALRRLHRLGHTSGADLAQGIAIGVAAVRSLSGVR
>NZ_CP017717.1|WP_080036418.1|330807_332418_+|PucR-family-transcriptional-regulator
MEPPVRLASTGTIIHGVSVGEVLGVSTLADARLIAGESGLGRIVQRLNVMEVPDILAWVKPHELLLTTGYPLRNTPQSLGRLVADLDERGLAALAIKLGRYVDELPGEMVEQADRLGFPLILLPNDVGFDDILNQVLTDILNRQAAVLARAEEAHRALVQVVLAGGGLDEVTAEVAKLLDVAVAAVDGSGRVLATAGPDDHVRALRESITREGLLTSRARTPAARARAFASVPVLAGGHHHGRIVAYSPAAAIRDSDVGILERAATVAALVVTRQEAVNAVESKYRADFLRDVLTGRAGTPERVTARARAFGWDLSRPVTVLVAELDPEGDERSAQDRLVSCWTAAIRRHDPRGAVAGFSHEVVAVVDAAIDASRVAKDAASAFADVPPATFSTGTSRPSPGAETLPEAYSQALKAARVGRQLHGPGAVAHFDQLGVYRLLSLVNDTDELHAFVRETLGPLASDDDAENADLRRTLQSLLETNLNVAETARRLHFHYNTLRYRIGKLERLLGNFTDDPHLRLNLTLALHVLRMRGI
>NZ_CP017717.1|WP_080036419.1|332429_332642_+|RNA-binding-S4-domain-containing-protein
MDDLEFELRDDYIPLCDLLKYCGITETGGMAKQLIDEGMVRVDGEVELRKRAKIRAGQVVTGDGFAIHVA
>NZ_CP017717.1|WP_080046421.1|332827_334045_+|nitrate-reductase
MVGIGAQHVIAMFGATFVFPLVMGLDANLAVMMSGVATILFLLIVNGKVPSYVGSSASFVGAVVAIRAAGGGDATVTGALLVVGAVLAVCGFAIHKLGVGVIHRVFPPIVTGGVVMLIGFGMAYVAADVYWPKDPWVALLTMAATFVFIGVFKGFLGRIGVLLGLVFGFVLSWVWDLVGGKILAPDDSGKVTEHFRVNLDAVAQADWIGMPSLHGPVFEASAVVLVLPVVIALIAENVGHVKAVGEMTGADVDAYMGRAVMADGIGTVVATSVGGSATTTYAENIGVMAATKVYSTAAYYIAAVIAILFGLCPKFGALVAATPGGVLGGVTTILYGMIGLLGAKIWIENKVDLSHPRNLVPTGAGIICAIGPVAFPITDTFALSGIALGTIVLLAGYHLLRAVRQ
>NZ_CP017717.1|WP_080036420.1|334195_335611_+|nitrate-reductase
MVVGWTKHGDGKHLAPGEVVRPDERLSWPRMVGFGAQHVIAMFGATFVFPLVMGLDPNVAVMMSGVATILFLLIVKGKVPSYLGTSASFVGGVFAIRAAAGGDVANADALVTGSILVAGFVLALAGVAIHVLGVGIIHRIFPPVVTGAVVMLIGFGLAFVVADVYWPQDHWVALATMLITFLVIVLFKGFTGRIGVLIGLVSGFVLSWVLDRVAGPVTSVLPGANLRDAAGNACPAEGTYCVATAFPHDRVGFQSVADAPWFGLPSFHAPDFRTSAVLLVLPAVIALIAENIGHVKAVGEMTGTDVDPYVGRAVLADGVGTMVTSAVGGSPTTTYAENIGVMAATKVYSTAAYYIAGIIAILFGLCPKFGALVAATPGGVLGGVTVILYGMIGLLGAKIWIENRVNFADPVNMVPIGAGMILAIGPVKHVIGGDFTLEGIALGTIVVLGGYHLLRAIAGRSPEPAVRGEAG
>NZ_CP017717.1|WP_080036421.1|335607_336432_+|molybdopterin-dehydrogenase
MKPPPFTYHAPRDLPAALRTLAEVGGKVLAGGQSLIPMLNMRLAAPGHVVDINRVAGLDGIEVSRAGVTVGALARHADVERAGAHPLLTWALKLVAHPAIRNRGTVVGSLVHADPAAELPAVLAVLGGHVRVARWDCGRVTFREIPAAEFFVGPMESAVGPGELAVSAFFPALEEGSGAAFHEVSRRHGDYALAGACAVVGVAGARVACIGVGGGPVVIDVGGDLSSAAARVRDAVDPDDDIHASAAYRRHLVGVLAERALRDAAREGAAARGA
>NZ_CP017717.1|WP_080036422.1|336265_336901_+|(2Fe-2S)-binding-protein
MWAVTCPRRRLAYGTPSTRTTTSTPPPPTAGTWWACWPSGRCATRRGKGRRPVEHEITLVVNGTARRARVPARRLLSDCLRHDLGLTGTHVGCEHGVCGCCTVLLDGRPVRSCLTFAVTVDGAEITTVEGLADRDGRMSAVQRAFAECHGLQCGFCTPGFLCTVTALLKENPAPTDDEVVEGIAGNLCRCTGYQNIVKAVHRAAELLAEEA
>NZ_CP017717.1|WP_080036423.1|336897_339249_+|xanthine-dehydrogenase-family-protein
MTTKLFGAPVQRREDPRLLTGQGRYLDDLGRDALAAAFVRSPHAHARVRDIDVSGALDVEGLVAIYTWEDLPERVGRALPLLIPHPALTHGRTAYPLARDVVRHVGEPVVMVVAADRYAAEDACALIEVDYEPLKPVVGIEEAVQGAQLVHEDVPGNVGAHLVQEVAAADGRGAREAIETSPHTLAFRLDIERSASMPLEGRGVYARWDGRDLRVYSSTQTSTSVRMAVAAALGLPLPQVEVIAPDVGGGFGVKIVHPWPEEVLVPWAAMTLGREVKWTEDRREHFVSSAHERGQVQYVRVGFDDDGRVLGLDVTILHDHGAYTPYGIIVPIVTSTQLLGPYKPGAYRVEFTAVYTNTVQVTPYRGAGRPQGVFCMERTMDKIARYLGKDRTEVRAANFIRPDEFPYDQGMTFQDGRPLIYDSGNYPEMLRMIKELIGWDTFERRPGLGIGIGCYVEGTGVGPYEGGHVQITSDGRVHVSTGLTSQGQGHETAFAQIAATELGVPIERVSVVTGDTRRFGYAVGTFASRAAVVSGNAIALACRKVREKALRIAADALEADPGDLDIADGIVHVVGAPSAAVPLSTVAVLANPLRYAFDEETAKATQFATAAAPDRPPVAEGEEPGLEGRDYYSPIRSTFAAGMHAAIVETDPDTAEIKVLRYAVVHDCGRLINPMIVEGQIHGGVAQGIGGALYERMVYDQHGQLVNASFMDFLMPYATEIPRVETGHLETPSPLNPLGIKGAGEAGVIPVSAVIASAVEDAEGIEINRMPISPSELFELRMG
>NZ_CP017717.1|WP_080036424.1|339257_340277_+|hypothetical-protein
MRAPDLIIAPDSGLTAFPDVPGGARIIDLAWNAITEVPSCVAGLGALEELRLDGNRLRELPGLSGLTALRALHLDGNELTALPALPPGLTTLFLYGNRVAALPDPLPASLRHLAAGGNALSSVPDSLWKLTGLESLNLAENALTEIPAAIGGLTRLRMLDLGHNRLAALPPELGDLPLTDYLYLSDNLLTDVPEWIGRLDRLAYLNLTDNRLESLPDTIGSMAALVELRLYNNRLERLPATIARLSRLRELHLQGNRLRELPPELPAGLRQLDLRDNLLRRLPETLPAGLKQLDLRNNRLRELPAELPDLDKLDLRWNKLDGEPEVLRRLAARGCVILR
>NZ_CP017717.1|WP_080036425.1|340373_340799_+|hypothetical-protein
MTTFPRLAAFALLAGLVAGCSSGGGWSDYAAAGNAQPATAAPMTIEQISKKVGCKPKMQVDADEVRTAYCKTQDGEFFVNTFKTEKLKDEWMDRAPEYNPHLVGPKWTVLGPLKVLEALRGPLNGDLHLTDHRTSMAPQPK

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Crispr_ID: NZ_CP017717_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_3

839443-839646

Orphan

Consensus_repeat	Method
CAGCCCCTCGGCCTGGAGTCCGGG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP017717_3

>merge|NZ_CP017717|3|839443-839646|CRISPRCasFinder
CAGTCCCTCGGCATGAGATTCGAGGGCTCGCAACCAGTCGATCTGCCGCCCCTTGACCCGCAATCCCTCGGCCCGGAGCCCGAGGCCCCACAGCCCGTCGACCCGCAGCCGCTCAGGCCACAGCCCCTCGGCCTGGAGTCCGGGGGCTCGCAGCCCTTCGGCTCGGTGTCCGGAAGCCCGCAGTCCCTCGGCCCGCAGTCCCTC

>NZ_CP017717|3|3|839443-839646|CRISPRCasFinder
CAGTCCCTCGGCATGAGATTCGAG	GGCTCGCAACCAGTCGATCTGCCGCCCCTTGACCCG
CAATCCCTCGGCCCGGAGCCCGAG	GCCCCACAGCCCGTCGACCCGCAGCCGCTCAGGCCA
CAGCCCCTCGGCCTGGAGTCCGGG	GGCTCGCAGCCCTTCGGCTCGGTGTCCGGAAGCCCG
CAGTCCCTCGGCCCGCAGTCCCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080036797.1\|830109_831039_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080036806.1\|848195_848555_+\|DUF2203-domain-containing-protein	unknown	unknown	gnl\|CDD\|378330
NZ_CP017717.1\|WP_080046474.1\|846092_847382_-\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP017717.1\|WP_080036802.1\|843131_843647_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|379082
NZ_CP017717.1\|WP_080036792.1\|821663_822836_+\|glycogen-synthase	unknown	unknown	gnl\|CDD\|273997
NZ_CP017717.1\|WP_080036794.1\|823814_827249_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173812
NZ_CP017717.1\|WP_155126483.1\|847505_848186_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP017717.1\|WP_080036799.1\|831870_833355_+\|DUF3131-domain-containing-protein	unknown	unknown	gnl\|CDD\|370812
NZ_CP017717.1\|WP_080036805.1\|845082_846015_-\|SPFH-domain-containing-protein	unknown	unknown	gnl\|CDD\|366488
NZ_CP017717.1\|WP_080036801.1\|842420_842876_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155126486.1\|848631_849627_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036803.1\|843643_844192_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP017717.1\|WP_080036796.1\|828837_830103_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP017717.1\|WP_080036795.1\|827294_827699_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|281995
NZ_CP017717.1\|WP_155126480.1\|833351_835067_+\|xylan-1,4-beta-xylosidase	unknown	unknown	gnl\|CDD\|366525
NZ_CP017717.1\|WP_155126489.1\|849632_850589_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036804.1\|844235_844913_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036798.1\|831035_831860_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080046472.1\|827848_828841_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP017717.1\|WP_155126477.1\|822847_823888_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197715

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080036797.1\|830109_831039_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.85504e-78
NZ_CP017717.1\|WP_080036806.1\|848195_848555_+\|DUF2203-domain-containing-protein	gnl\|CDD\|378330	pfam09969, DUF2203, Uncharacterized conserved protein (DUF2203). This domain, found in various hypothetical bacterial proteins, has no known function.	1.03279e-37
NZ_CP017717.1\|WP_080046474.1\|846092_847382_-\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.075e-177
NZ_CP017717.1\|WP_080036802.1\|843131_843647_+\|adenylyl-sulfate-kinase	gnl\|CDD\|379082	pfam13238, AAA_18, AAA domain.	0.000137523
NZ_CP017717.1\|WP_080036792.1\|821663_822836_+\|glycogen-synthase	gnl\|CDD\|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP017717.1\|WP_080036794.1\|823814_827249_+\|S8-family-serine-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.21569e-71
NZ_CP017717.1\|WP_155126483.1\|847505_848186_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.58637e-37
NZ_CP017717.1\|WP_080036805.1\|845082_846015_-\|SPFH-domain-containing-protein	gnl\|CDD\|366488	pfam01145, Band_7, SPFH domain / Band 7 family. This family has been called SPFH, Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.	1.37825e-13
NZ_CP017717.1\|WP_080036799.1\|831870_833355_+\|DUF3131-domain-containing-protein	gnl\|CDD\|370812	pfam10091, Glycoamylase, Putative glucoamylase. The structure of UniProt:Q5LIB7 has an alpha/alpha toroid fold and is similar structurally to a number of glucoamylases. Most of these structural homologs are glucoamylases, involved in breaking down complex sugars (e.g. starch). The biologically relevant state is likely to be monomeric. The putative active site is located at the centre of the toroid with a well defined large cavity.	7.77196e-13
NZ_CP017717.1\|WP_080036803.1\|843643_844192_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	6.29456e-26
NZ_CP017717.1\|WP_080036796.1\|828837_830103_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.64852e-115
NZ_CP017717.1\|WP_080036795.1\|827294_827699_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	2.77783e-49
NZ_CP017717.1\|WP_155126480.1\|833351_835067_+\|xylan-1,4-beta-xylosidase	gnl\|CDD\|366525	pfam01229, Glyco_hydro_39, Glycosyl hydrolases family 39.	4.44956e-82
NZ_CP017717.1\|WP_080036798.1\|831035_831860_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.18255e-85
NZ_CP017717.1\|WP_080046472.1\|827848_828841_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.34005e-88
NZ_CP017717.1\|WP_155126477.1\|822847_823888_-\|hypothetical-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.68439e-07

>NZ_CP017717.1|WP_155126480.1|833351_835067_+|xylan-1,4-beta-xylosidase
MIATPTGLRAVPGAGHVTLTWDPVPGAIGYLVHRDGAPAVPAEVDVPAVPACRFVDTGHGFATYTVAALCPRQGPFSAPVEAAPLPARAGTTVPVRVDAGRVTRELPRPWTPMIGSEHLSHLLSTDRTGGRPIGEELAAALRLAREELGVKAVRAHAVLGDDLGVYRHGEPYDFTRIDAVYDRVVALGLRPVVELGFMPRDLAADPSRTVFQYEAIISPPKDFEAWGDLVRALVEHLAARYGLRDLIDRWAFEVWNEPNLDVFWSGTREEYFLLYDVTAAAVRDVHPDLRVGGPASAANGWVEDLLAHVARSGAALDFVSTHTYGNAPLDWRPVLSAYGRDVPIWWTEWGPTPTHFHGIGDGPFGAAFVLHGMKSAAGRIDALSHWVVSDHFEELGRPPRLFHGGFGLLTVGNLRKPRFHALALAQRLGEAELFSEVGGDAAGVEAWAARHGDGRVGILIWNGTLNSAQAAGAPELARVIDLTVEGLDRGTYTLTHHRIDATHTNVEAVWQAMGGGDWPTGDQWETLRRADGLDRLTPPTTVTGPTLTLTFDLPMPAVSFLELTPDRPSEA
>NZ_CP017717.1|WP_080036799.1|831870_833355_+|DUF3131-domain-containing-protein
MRVLSCLLVLSLTTPMNADDTLWRYAKDTWRSMTAMVEPATGLPADKVTGDLKTRARITSPTNIATYVWSTLTARDLRLITPRDATARIGKVLDALARLERNTPTGQFYNWYDPATLQLARSFPDSGDPIHPFASSVDNGWLATALMMVRNAIPAHAKAANALLASMDFTAYYDPAARPDAGTGLLRGGFWPEPPPQDCNLPTDYAGTGVTVYSTCHHYGAPAETRIGQYVGIALGQLPPESYFGPYRTFPDNGCDYGWQEQRPTGSWKRYMGVNVWEGTYEYRGLRYVPNWGGSMFEALMPDLVVPEARWAPRSWGRNHPVFVRAQIEHGLNEAKYGYWGFSPSNDPHGGYNVYGVDQLGMDEPGYPSDRERTSVDPGYEGCRPAKPLPQAYGDGVVTPHASFLALPYARQAALDNLAKLRRDFDAYGPGGFYDAIAVRTGVVSKWYLALDQGMAMAALGNVLAGGALHRYFAGSGVESKLRPVLRLEDWQVG
>NZ_CP017717.1|WP_080036798.1|831035_831860_+|carbohydrate-ABC-transporter-permease
MTRTTRRQRLVVHLGLSLGLVLVAGPFLWTALSSLKPEREIRRDPPTFWPETWTLGNFAELFGRVDLGTAFANSMIIALVLVATNLLFCSMTGYAFAKLSFRGKNLAFGLVLVQLAIPAIVVMMPQFVLIARLGMVNTFIGIILPTLVTPLGVFMMRQFIADLPDELIDAARVDGAREFRVFFTIILPLCGPALATLGLITFLGSWNNFLWPAVVAQSEDMYTLPVALNILNGNEGTHYNLLVAGSVVVIAPILFLFVFLQRFFIQGIATTGLK
>NZ_CP017717.1|WP_080036797.1|830109_831039_+|sugar-ABC-transporter-permease
MAVLTRQAPPAPAPVKVRGVLRRSGLGWVFIAPFVVLFAVFYLGPLLVGIGMSFTDLRSTDVADPLAVDVVGVENYLRLMNDGAMHRAALNTVVFVLTALPLTIGLGLAAAVLLNSGIARLPAAFFRLGYYLPNVTSIIGVAVAWKFLLEPEAGLVNRLLALVGVDGPNWLDDEATALPSIIVMTAWRSFGFDMVVLLAALQTIPKELYEAAAVDGAGRWARFHAVTLPSLRPVLLFCTVYSSVGFMQFLEEPLVMTRGGPLNATLSASLAIFGQFGVGNYGYAGAASTVLFTVIVALAVLQLRLGRRR
>NZ_CP017717.1|WP_080036796.1|828837_830103_+|sugar-ABC-transporter-substrate-binding-protein
MTTTTRRAAAGALAIAMLAAGCGRGTGTAQERARDVTTANATGEVTVWAMGEEGKALGAFVKGFESAHPGVKVNVTAIGWDVAHDKITSAIAGGATPDVSMIGSTWSGELAKTGALEPTPGNLVDKAAFFPGAWQTVDINGTAYGVPWYVETRVLYYRTDQARRAGVQPPRTWEEFTAFVRALKDKGGARRGFNQSYQLGASWQEVLPLIWQAGGEIVKDGKYTFDTPEAVTALKQYASLFQQKLAPTDTPANAFPQTFIKGEVGAFYSGPWMIGVLNDDGGPGFAGKFGVAPYPKGPVSATSFVGGADLAVFKKAKNRDAAWALIKWLSEPKVQAQWYTTVKALPAVQAAWQEPELKADEQLAVFGEQLKDARTPPPFPTWEQVARVLEAELEKLARGRSTPERTAKAIQAQADTIGTGL
>NZ_CP017717.1|WP_080046472.1|827848_828841_+|LacI-family-transcriptional-regulator
MTIYEVARRAGVSIATVSRTLRGTGPVAAKTREKVLKAVEELNFTPSRLGVSLAEGRHAANGVVFPDLAGPYYAEVLLGYEEVASELGRSVIILSTKGRTRVGDLIKDLAGRVDGMLIFGHTVPEPLVAELVRLGVRLVFVSRDPLPGADTLRSENTASARALAAHLADHGYERFAFLGAPLTSHDDVDERWRGVRSVLGGAIEAVDTGHYTVECGHEAATKLLKGRDRPRAIVCSDDEVALGALLAAEELGLDVPGDVAVTGWDDIMAARHARPALTTVRQPMRELGARAARALDELITGVRDTPSHHTLATAPVIRASCGHHPQEVRT
>NZ_CP017717.1|WP_080036795.1|827294_827699_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MLYGEEHVRRYRETDGAEGHDWNDTTVLLLTTKGRKSGRPFTTPLIYQRFGDDYLVVASKGGDPDHPGWFKNLQASPEVEVQVKGDRFKARARTATPEEKPEMWRVMARTWPDYDEYQKKTDREIPVVVLERAT
>NZ_CP017717.1|WP_080036794.1|823814_827249_+|S8-family-serine-peptidase
MPTISSALPSSCTRSILAVSGSCRNRPPTPPCHQISLTIRKRDVQQRTALLGVVLLAATAIAAPAQAAPAPPAPPAPKLGPAKTITLITGDKVTLRALPDKQTQLDVAAGPGREKIDFVRRRSADGLSIVPVDALPLLAAGTLDPRLFNVTRLAALGYDDAASPRLPLILTYPDSNQAALRAAGGRPLPAINGVARKEPRTGALWQTLTAQARTAAAPAKIWLDGKARVSLDVSVPHIGAPAAWAAGHTGQDVPVAVLDTGYDPAHPDLKGQVVKTENFTAEPDTTDLNGHGTHVASTIAGTGAASGGTRKGVAPGAKLMIGKVCGQDGYCADSAIVEGMTWAAQNGARVANLSLGGPDAPGVDPLEQAVNTLTAEYGTLFVIASGNDGPQALGSPSSADAALSVGASYRDADAVAQFSSTGPRPGDAAVKPDLIAPGVGIVAARAGAPEGASGDELYAEMSGTSMATPHVAGAAAVVAGLHPDWTAARIKAALMAATAPGEELGAYIQGSGRVDVARAVGQRITTEPASLTMGDVELPDTAPKERTLTYRNDGDAAIRLELSVVAKDGHGESAAPFTLGAGAVEVPAHGTADVKVTAKPGATGLFSGTVIAKGGDVTVRTGIGMRVEPEKKALGLRFTGSDGRPAQTAFAGVIDIEAGEQTNYDISGGSLDLRLLKGRRYTVVTLLADHDGTIVMAAEPEFTLDGDRTVTADARRAKPVDVRTEEPTARLAIGMVGLLQLVEGAQPLGVDVDLAGQWGTDRVEGVKAIPTTRTVSKKFAYYRWTQWARPQADGTYHASPYFYHLMKAEPRIPADPGYRPRRRDLAEVTSTYAAQRDGKTGEHMALPVLYGTELAWMPYVHVAHVPLPFTRTEYYTPGDTGWYPSFAQYKLPPDGFDDLDQFFFGRTTVYRAGQKSTERWNGAVLGAALNPGGDYTWREGNSLQFAVSLFDDGRPDRYSVGSYTAPRATLYRDGKEVYSTSDYLPGWIDVPADRKESEYRLTMTAGRDPAMTALSTRVSAEWRFRSKTPAAGERQVLPLLAVKIDPELDARNQAAVGPMRLPLRVQRQAGSPDLPLRALTVDISYDDGRTWLPTLVHPSGKGTWAAETWHPSGARGRFASLRVKAADAGGNAFTETVTRAYLIK
>NZ_CP017717.1|WP_155126477.1|822847_823888_-|hypothetical-protein
MRQLPETAKIERVQEDGRALEIVGISAFDERIYRSVLACPGITVQELVRRSGESSGRIQSSLSRLRVKGLVSRLWGRSPRWTATNPGTAIRALVRDMQSELDLLTDTADELEAAFRDVGTDPAGGDQIEVLAGPEEQARWYVRLQQEAKEEVLTFDRPPYVLDYHNPLQTDLLRNGVRYRTLYVPEAFDHPGALDEVGSLIRAGEEARILPWLPFKMALVDRSRAVMPLHMEPPLTRGVLIRGSTMVVALVELFERLWREALPVRPELWSHGVPEPQVEPDPGAGLSVEDRRLLALLAAGLKDDAIARQLGTSPRSLRRRLRHLLDELNAETRFQAGAQASRRGLV
>NZ_CP017717.1|WP_080036792.1|821663_822836_+|glycogen-synthase
MRVDLLSREYPPEVYGGAGVHMEYLARELRKLADVRVRCFGAERDEPGVSAYRAPAELSGANAALQVLGVDLEMAAACAGADVVHSHTWYANFAGHTAKLLHGIPHVVTTHSLEPLRPWKAEQLGGGYAISSWAERTALAAADAVVAVSEGMRRDVLAAYPEIPPERVTVIHNGIDTAQYAPDPGTDVLARHGVDPGRPYVVFVGRITRQKGLVHLLHAARSFDPAAQLVLCAGAPDTPEIAEEVTGLVRGLDRDGVVWIQEMLPKPEVIQLLTHATVFVCPSVYEPMGIVNLEAMACETAVVATATGGIPEVVADGETGLLVPIAQGADGTPHDPERFAADLAERVNALLGDPARARAMGEAGRARAIEHFSWERIARRTLDLYTALKG
>NZ_CP017717.1|WP_080036801.1|842420_842876_-|hypothetical-protein
MLDSLIVPLFVTTDLPPEAELAEFGELLTETTRVLGRDEPGYEAFLAGKVFWLDRPVLPEQLPPAEGELRFAGMLGYLAASGAGHTTREVVGDVRRAIGAAVTSRYGDVGVAPAVFAIRDQDVRERTPENALYVDTRDAAAELVSATKSYL
>NZ_CP017717.1|WP_080036802.1|843131_843647_+|adenylyl-sulfate-kinase
MPKALLITGTVGSGKTSVADAVGDLLADRRVPNAVIDIDWLRRAWPSPPSDPFHGELTLRNLRPVAANYLEAGAERLVLAGVVESRAERDAYEEALGVPLKVCRLHVELPEVRRRLEARHAFDPEGLDWHLKRSGELAPILEAARVEDFVVDGSDGLPPQVATRVLKNWTS
>NZ_CP017717.1|WP_080036803.1|843643_844192_-|GNAT-family-N-acetyltransferase
MRRVVCNGERLGLRDVTEADVTALHTIYSHPAAVQHAPFAPRSLQEVTGLVEEAMEAAAAEPRRLYVLAVVDAGRRDVIGVARLRIEADLPHSAEIGFGLHPDQWGRGIGTDLVRLLLSFGFKQLGLHRIWGARSPANLPAQLAMLTAGMVEEGRIRHHLHTPNGWRDSIVHSAIEGEWTER
>NZ_CP017717.1|WP_080036804.1|844235_844913_-|hypothetical-protein
MLVLATPGGTAGVAEEIAAVVRVDNPQIEVRLTSVTDLADSLPAGRDAVIVPLLTWEDPAVMAEIGKAVAAAGSGAVVTEALGPHPLLAEALHIRLAERGLARADRVRLLNVSSPVDAVILATVGGERAVHALQATAVLLASRLTLPVVAASLDSEPGVPVAAQRLRAAGAERLAIAPCLIGHEAPAGIVEQAAAAINAGHAQPLGAHSAVAELVARAYGSQLAT
>NZ_CP017717.1|WP_080036805.1|845082_846015_-|SPFH-domain-containing-protein
MRTALAVIAALLAIPLVIGVVGGMESTGGGEVAVVRDGGPLDDNKVRQVIDPGSGLTWTGMWSSVHLYPAQQRFYTITADAKRATTLGVDVVTVPSSDGVNLGIEGTLYFTLNLDHETLKTFDDRYGTRTFRTQGDTALYPWDGDEGWAAFFGQAVRPVIDNALRGQIGAMRCAELVPSCSLLESSALKPQDSNANIAKVQDAVNASLARDLPATLGGSFLTGLRFTLAKVTLPADVQKAVDRSLSAAAAVSEAEAKVAQAKAEAEANRARQDGYDKCPACAEIEKLRSLPQGITVYAPGNPQSVVIPSR
>NZ_CP017717.1|WP_080046474.1|846092_847382_-|MHS-family-MFS-transporter
MILASLIGTSLEWYDFFLYTTAATLVFPKLFFPSLDPFSATLASLTTNAVAFVARPLGGVVFGHFGDRVGRKTVLVVTLLVMGVSTFLIGVLPGYAAVGVLAPILLAVLRFVQGLGLGGEWGGAVIMSLEHGDGRRRGFNASWPQVGVPAGYVLATGLLTIMNVTMSDAAFLSWGWRIPFLLSGALVFVGLWVRLRITESPLFAEVEQQGAKAKMPLVEVLRTHPRALLSAFTARIGVDVAFYTFTAYIIVYITGELGLPRSYALNAVLIGSALQLALIPLAGALSDRYGRRPVYLVGVVGAAVWVFAFFPLLDTKSFPLIALAAVVALVTHAAMYGPQAAFIAELFSTRLRYSGASMGYQVAGIVGGALAPVIALQLFESFQSTLAVSIYVVVALAVTALGLAIAPETRDLNLAEPPRSKAPQVGPFA
>NZ_CP017717.1|WP_155126483.1|847505_848186_+|GntR-family-transcriptional-regulator
MDNVVADLSQDRPRLGRSSTAERVADILRDRISEGFFQPGQRLSEESISEALGVSRNTLREAFRLLGHERLLDHRLNRGVFVRLPSVEDVLDLYRVRRVLEGAAVRRKPSKEALAVIKEAVADARRAAAGDDWQAVGTANIRFHQALVSLNESPRIDETMRQLLAELRLVFHVMENPRAFHEPFLERNRILVGLIESGRPEEAAAYLDDYLDHAERLLIHAYEPNR
>NZ_CP017717.1|WP_080036806.1|848195_848555_+|DUF2203-domain-containing-protein
MERIFTLDEARALLPAVMREAAELIAARADLAEIDFERRTGGRSELGGLPELKGLQARIEEILSGWSEQGIEVKGIAPVLVDFPSLLDGVSVRLCWIEGERELGWYHRTELGFAGRRPL
>NZ_CP017717.1|WP_155126486.1|848631_849627_+|hypothetical-protein
MRHSSMIAALLAPAVIGTLGLTTPAYARAAPPAARVAWIKSCYDKKRQDTDPCGAWRLRLRDGGQATVPGAATRGVNGKGREAHLASTFAVSGDGRVLLYERARDHRLVVRPVSGGPAKVLPEDARPKGIGSDEMAVRLSPSGERVLIDYYDADDRLPSKVITVATGETATVPAAYGVLGLSADGDEVLATRLAGDNTTTLYALRPGGGATRRTPPQVIANAGAWALAADGTTVAALVQGDAERKEPARIRTYDLATGELSEGVDVPAGPHFEPSSAWWDGDLLRATYTRTASTGNSAVVRVLTVDPGTGRIEHDDQYKIGENYAFAAAGE
>NZ_CP017717.1|WP_155126489.1|849632_850589_+|hypothetical-protein
MRIRILTALTVASALAWPAPAHAAHDDSIRYASIKACPVKGGGQRACGDWRLVMHDGRRATLPDAQGVAKEADGTSNRYTPAPIAVSGNGRHVAYFTKQGRLAVRTLGGGVQRLAAGALPKVAQYDVTLLLSDDGARLAAVVGGEKPAGTRVFDTRTGDLLGTLPAELTVLGFSGDGGEVLTTTTGAENVTELVVYSDTGEELRRATPPQVIVSNVPQALAGDGRTVASLVTGSKAELVTYDADGDQIAGRKRVKLPAGDLQMLDWTADDQVTAHLTSDASGTTRMTIVQIDTETGAVRVRDRYTVLPDSFVFAACGG

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Crispr_ID: NZ_CP017717_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_4

1158981-1159093

Orphan

Consensus_repeat	Method
GTGGTTCGCACCGTCCGCCTGGTTCACCTGGTCCGCGTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_4

>merge|NZ_CP017717|4|1158981-1159093|CRISPRCasFinder
CTGCTCCGCCTGGTCCGTGTGGTTCGCACCGTCCGCCTGGTTCACCTGGTCCGCGTGGTTCGCACCGTCCGCCTGGTTCACCTGGTCCCCGTGGTTCGCACCGTCCGCCTGGT

>NZ_CP017717|4|4|1158981-1159093|CRISPRCasFinder
CTGCTCCGCCTGGTCCGTGTGGTTCGCACCGTCCGCCTGGT	TCACCTGGTCCGCGTGGTTCGCACCGTCCGC
CTGGTTCACCTGGTCCCCGTGGTTCGCACCGTCCGCCTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080037034.1\|1155675_1156440_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|234840
NZ_CP017717.1\|WP_080037030.1\|1149559_1150435_+\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|234869
NZ_CP017717.1\|WP_080037041.1\|1175897_1176338_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377906
NZ_CP017717.1\|WP_080037036.1\|1156868_1158137_+\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NZ_CP017717.1\|WP_080037037.1\|1160188_1160578_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP017717.1\|WP_080037033.1\|1153040_1154240_+\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NZ_CP017717.1\|WP_155129507.1\|1173209_1174634_-\|DUF1015-family-protein	unknown	unknown	gnl\|CDD\|377633
NZ_CP017717.1\|WP_080046513.1\|1170790_1171783_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293812
NZ_CP017717.1\|WP_080037032.1\|1151594_1152518_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NZ_CP017717.1\|WP_080046511.1\|1160687_1161125_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP017717.1\|WP_080037040.1\|1175309_1175732_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP017717.1\|WP_155126573.1\|1152514_1153021_+\|arginine-repressor	unknown	unknown	gnl\|CDD\|235116
NZ_CP017717.1\|WP_080046514.1\|1171706_1172237_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|366099
NZ_CP017717.1\|WP_080046512.1\|1169246_1170473_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380149
NZ_CP017717.1\|WP_080037035.1\|1156379_1156781_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP017717.1\|WP_080037038.1\|1166861_1167602_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|316372
NZ_CP017717.1\|WP_080037029.1\|1148411_1149563_+\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	unknown	unknown	gnl\|CDD\|235441
NZ_CP017717.1\|WP_080046510.1\|1154272_1155694_+\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_CP017717.1\|WP_080037042.1\|1176416_1177388_+\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP017717.1\|WP_080037031.1\|1150431_1151598_+\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|235112

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080037034.1\|1155675_1156440_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|234840	PRK00802, PRK00802, DNA-3-methyladenine glycosylase.	5.79939e-84
NZ_CP017717.1\|WP_080037030.1\|1149559_1150435_+\|acetylglutamate-kinase	gnl\|CDD\|234869	PRK00942, PRK00942, acetylglutamate kinase; Provisional.	1.66454e-149
NZ_CP017717.1\|WP_080037041.1\|1175897_1176338_-\|hypothetical-protein	gnl\|CDD\|377906	pfam07739, TipAS, TipAS antibiotic-recognition domain. This domain is found at the C-terminus of some MerR family transcription factors. The domain has an alpha-helical globin-like fold. The family includes Mta a central regulator of multidrug resistance in Bacillus subtilis.	8.48517e-45
NZ_CP017717.1\|WP_080037036.1\|1156868_1158137_+\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_CP017717.1\|WP_080037037.1\|1160188_1160578_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.83228e-37
NZ_CP017717.1\|WP_080037033.1\|1153040_1154240_+\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NZ_CP017717.1\|WP_155129507.1\|1173209_1174634_-\|DUF1015-family-protein	gnl\|CDD\|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	3.978e-58
NZ_CP017717.1\|WP_080046513.1\|1170790_1171783_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293812	cd07726, ST1585-like_MBL-fold, uncharacterized subgroup which includes Sulfolobus tokodaii ST1585 protein; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Sulfolobus tokodaii ST1585 protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.62519e-92
NZ_CP017717.1\|WP_080037032.1\|1151594_1152518_+\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	5.95065e-177
NZ_CP017717.1\|WP_080046511.1\|1160687_1161125_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.40977e-18
NZ_CP017717.1\|WP_080037040.1\|1175309_1175732_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.82745e-10
NZ_CP017717.1\|WP_155126573.1\|1152514_1153021_+\|arginine-repressor	gnl\|CDD\|235116	PRK03341, PRK03341, arginine repressor; Provisional.	4.0143e-77
NZ_CP017717.1\|WP_080046514.1\|1171706_1172237_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|366099	pfam00436, SSB, Single-strand binding protein family. This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	2.41461e-07
NZ_CP017717.1\|WP_080046512.1\|1169246_1170473_+\|hypothetical-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	5.29306e-10
NZ_CP017717.1\|WP_080037035.1\|1156379_1156781_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	2.65806e-06
NZ_CP017717.1\|WP_080037038.1\|1166861_1167602_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|316372	pfam13847, Methyltransf_31, Methyltransferase domain. This family appears to have methyltransferase activity.	4.24363e-19
NZ_CP017717.1\|WP_080037029.1\|1148411_1149563_+\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	gnl\|CDD\|235441	PRK05388, argJ, bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ.	0
NZ_CP017717.1\|WP_080046510.1\|1154272_1155694_+\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP017717.1\|WP_080037042.1\|1176416_1177388_+\|HAD-IIA-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.33829e-91
NZ_CP017717.1\|WP_080037031.1\|1150431_1151598_+\|acetylornithine-transaminase	gnl\|CDD\|235112	PRK03244, argD, acetylornithine transaminase.	0

>NZ_CP017717.1|WP_080037036.1|1156868_1158137_+|tyrosine--tRNA-ligase
MTDILDDLAWRGLIAQSTDLDALRASMAKAPITVYCGFDPTAASLHVGHFVPLLTLRRFQLAGHNAIGLVGGATGLIGDPSGRNTERSLNSTEVVAEWVERLRGQVGRFLDFDESRPNPARLVSNLDWTGELSAIAFLRDIGKHFPVNRMLARESVSARLAGEGLSYTEFSYQILQSNDFLELYRRYNCTLQIGGSDQWGNITAGADLIRRVEGAHVHVITQPLITKADGTKFGKTAGGALWLDPAMTSPYAFYQYFLNSDDRDVIHYLKVFTFRSREEIEQLEKAVAERPFAREAQRTLAEDLTELLHGRQELDAVLAASKALFGQGALEELPAATLEAALAEVPKAAVPALGASFVDLLADSGLVESKSAARRAVKEGGAYLNNRKITDESYVPAAEDLLHGRFMVLRRGKKSIGGVTVG
>NZ_CP017717.1|WP_080037035.1|1156379_1156781_-|PH-domain-containing-protein
MWRVRRELAVFKILGALVCAGLGVYWWFGDDFRGVILAVPAAVLVGGMGLRDLLVPVRLAADPSGITVVHGFAGRRHVPWEAIWDVKVDVRRRWGLRSEMLEIDTGDDLHIFSPHDLGASPTEVAAALRRRGT
>NZ_CP017717.1|WP_080037034.1|1155675_1156440_+|DNA-3-methyladenine-glycosylase
MGRGELSFDWGGAGLSPAPLPRSFFDRPSPEVAPDLLGRVLAHGSVAVRLTEVEAYGGPGEDPAAHTYRGRTPRNAVMFGPPGHLYVYFTYGMHFCANLVCLPEGSGSAVLLRAGEVVAGLPEARLRRSPGASQGEAGSDGGVRPAGRRVADRDLARGPARLAVALGLVREHNGLDTILEGSPAGRPHDSLTVLEGRPADPALIRSGPRTGVSTAKETPWRFWIDGDPTVSPYRAHVPRRRSAAATSVGEAPRS
>NZ_CP017717.1|WP_080046510.1|1154272_1155694_+|argininosuccinate-lyase
MTVSDGKPMRLWGGRFESGPSDALARLSVSVHFDWRLVPYDLAASRAHARVLHRAGLLTADELERMIGALDDLEQACKAGEFRPTVADEDVHTALERGLLERLGSLGGKLRAGRSRNDQIATDLRLYLRDHARSVVSRLVELETALMAQAEQHAETAAPGMTHLQHAQPVSFGHQLLAHVHAFARDVDRLTDWDKRAAISPLGAGALAGSSLPLDPQAVAEELGFSAAAPNSMDAVADRDFAAEFLFDAAMIGVHLSRLGEEIVLWASQEFRWIEMDDAYSTGSSIMPQKKNPDVAELARGKSGRLIGNLMSLLTTLKGLPLTYNRDLQEDKEPVFDAVDTLLLVLPAMAGLVATMRVNTARMEASAPDGYALATDLAELLVRRGVPFREAHEAVGHLVVWCQVNDKDLGELTDDELAKVSPHLTPDVRGVLSVPGALAARKAHGGTAPDRVRDQLVALREAVDAQAAWAAGS
>NZ_CP017717.1|WP_080037033.1|1153040_1154240_+|argininosuccinate-synthase
MPDRVVLAYSGGLDTSVAIPYLAEKMNAEVVAVAVDLGQGGEEMEAVQKRALDCGAVESVVVDAKEEFAADFCVPALQANALYMDRYPLVSSLSRPLIVRHLVSAARRFGGTIVSHGCTGKGNDQVRFEAGLAALAPDLQVIAPARDFAWTRDKAIEYAEAKGLPIETSKKNPFSIDQNLWGRAVETGFLEDIWNGPTEEVYSYTADPKQPREPDEVVITFERGVPVKLDGRALTPYQIIGELNRRAGAQGVGRVDMVEDRLVGIKSREVYEAPGAITLIAAHMELENVTVERDLARFKRGVDQRWSELVYDGLWFSPLKNALDALIADAQKHVNGDIRMTLHGGSATVTGRRSEDSLYDFSLATYDTGDTFDQSLAKGFVQLFSLPAKIAAARDARKG
>NZ_CP017717.1|WP_155126573.1|1152514_1153021_+|arginine-repressor
MTIPMTKAARQAKITDLLQRKAVRSQPELAKLLAESGVEVTQATLSRDLDELGALKLRADDGSLVYALPGEGGGRIPLTRLGTGESPAARLHRIAEELLVGAEASANLVIVRTPPGAAQFLASAIDHADWESILGTVAGDDTILVISRDPAGGHALAEALLKAADRRS
>NZ_CP017717.1|WP_080037032.1|1151594_1152518_+|ornithine-carbamoyltransferase
MTVRHFLRDDDLTPAEQAEVLDLAAAMKKDRFGYRPFEGPRSVAVLFDKPSARTRVSFHTGIGELGGLPLIVDNVSVLMGRGEPTADIARVLERQVAAIVWRTTGQELIEEMAAHSRVPVVNALTDEFHPCQILADLQTVQERLGRTAGLTLTYVGDGANNMAHSYLLGGATAGMHVRVAAPAGYQPDAVILDQAAAIAAKTGGSVVALSDPAAAAEGAHVIATDTWVSMGQDGKEERMAALMPYQVNAELLAHAAPDAIVLHCLPAYRDHEITPEVLDGPQSVVWDQAENRLHAQKALLHWLVSRP
>NZ_CP017717.1|WP_080037031.1|1150431_1151598_+|acetylornithine-transaminase
MSLFERFENAFMPNYGVPPVALARGEGSRVWDVDGKEYLDFIAGIATSSLGHAHPALVEAVSQQVATIAHTSNLFLHEPEVLLAERLLALLDTPARVFLANSGTEANEAAYKLALKYGRREGRSYFVAAENGFHGRTIGALSLTGKKAIRDQFGPFPVPVRFVPYGDADALKEAVTGDCIAVFLEPTQGEAGVVPPPDGYFEAAREICDSTGALLVADEIQSAIGRSGHWFAHQADGVTPDILTLAKGLGGGLPIGACVGFGDVGKLFEKGDHGSTFGGNPVSCAAALAVLDHVDLDHVRAMAARLRGGLESVRDPLLKGVRGRGLWLAAVLAEPRSAQVQQAAANAGFLVNALQPDAVRIAPPLVVTAEEVDAFVSAFPAILSEAAK
>NZ_CP017717.1|WP_080037030.1|1149559_1150435_+|acetylglutamate-kinase
MRLTTAQTKAEALIEALPWLTRFHGATVVIKYGGNAMTEEALKEGFAEDVVFLHQAGLRPVVVHGGGPQISDALNKAGIASTFTAGLRVTTPEAMQVVRMVLTGQVNRDIVGLVNRHGPFAVGMSGEDAHLFTAVRKHAIVDGEPVDIGQVGEIIKVDPGAVNALLDNGRIPVISSVARGDDNEIYNVNADTAAAALAVALQAQKLIVLTDVEGLYASWPDDTDVIDLLTADELEAMLPTLSSGMVPKMEACLTAVRGGVPRAHVLDGRVPHSLLLEIFTNEGIGTMVMPS
>NZ_CP017717.1|WP_080037029.1|1148411_1149563_+|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ
MSVTAPLGFRAAGVAAGIKSGGARDLALVVNDGPSRAAAGVFTANRVKAAPVLWSQQVLAGGRLRAVVLNSGGANACTGPEGFQDTHATAEKVAEALDDSAGEVAVCSTGLIGERLPMEELLAGVETAAGQLSRDGGLAAADAIRTTDTVSKISFKRGTGYMVGGMAKGAGMLAPALATMLCVITTDADLTSEELDAALRRATSVTFDRLDTDGCMSTNDTVLLLASGAAGVKPDLAEFGQRVIDVCADLARQLLVDAEGASKAIAIEVVGAASEDDAVKVGRSVARSNLLKCAIHGEDPNWGRVLAAVGTTDAEFEPDRLNVAINGIWICRGGAVGDDRSKVDMRPRDVTITIDLSAGPHTATVHTTDLTADYVHENSAYSS
>NZ_CP017717.1|WP_080037037.1|1160188_1160578_-|PPOX-class-F420-dependent-oxidoreductase
MRVIPESHLDLLTRPLFAHLATIGPDGTPNVNPVWTIWDGEYLRFTTTTDRRKCRNVQQNPNVAVSINDPEKPYRYLEIRGVVERVEPDPSGTFFDVLAKRYGLAYEPPLGDAERRVVIVVKPTRTTQQ
>NZ_CP017717.1|WP_080046511.1|1160687_1161125_+|MarR-family-transcriptional-regulator
MPADERLGLDIKRAEQALIAAKQAAVRPAGLTVPQYATLLALAGNPGISGAALARVCLVTPQAMTVVLKNLEERGLIERSPHPWHRSVLETRLTETGRAALEAADERAVVIERAIAAEFSAEERKTLRGLLARCNDAIARAASEL
>NZ_CP017717.1|WP_080037038.1|1166861_1167602_-|class-I-SAM-dependent-methyltransferase
MSLRFHEIAESRHRILNPLTDDKLNLLGEICHFGSGTRILDLACGKGELLSRWAADYGIQGVGVDISKAFLNAAAIRAEELGVADRVEFVEADASAYEAAPESYDVVSCIGATWIGGGLTGTLELMRRWLRPNGIVLVGECYWTSPPPPEACNALQVDKDAFTSLPGTAERAESAGFELLEMVLANPDSWDRYVASQWWTISDWLRENPDDPDAPAMRGFLTQARRSHLEYGRDYLGWGVFVLRPS
>NZ_CP017717.1|WP_080046512.1|1169246_1170473_+|hypothetical-protein
MPDVPPDITVDELDKEVLEELRSLPGDLADLVGRHLVAAERALEEDDPDRAHEHTKVARRFAARIGVVREAAGIVAYRAGHFSEALSDLRAARRMTGSDAYLPVMADCERGMGRPERAIDLVRSPEAERLDRAGRIELTIVESGARRDLGQHDAAVITLQRLPELRDPQPRPWSARLAFAYADALADAGHQDAATDWFGRAMAFDEDGETDAAERYAELTGAVIEDVEEDFDEEDDFDDAGVSGAEDVARVDEEADDAAALAEAGDLLSAEIDADVDEDADEYADADADTDADADADVEAVASANAEADADVDEYADAAYAPSSRADVDVEAASDDEADEDDRVPASKAADEASAESEDDSDGDASPEAAAAETGVPGITPAFIEPNFGDVLDDDAESRTEKKPKNES
>NZ_CP017717.1|WP_080046513.1|1170790_1171783_-|MBL-fold-metallo-hydrolase
MRRRPDRLNAVLGTTAGGSGVAVDNITALGGDVYEIDTRMAGFAGITAGYLILSDRPCLVETGTSTSAPVVRDALASLGVGPEDLATVVVTHIHLDHAGGVGDIAKFFPSAQVVVHEKGARHLAEPSRLMASARMVWGDRLDTLFGELSPTEAERIVALGDTGAIDLGNGRTLNSHYSPGHAKHHVGLVDSATGDLYVGDAAGVYLPETGDLRPATPPPDFDLNTALDSIALFEALEPQRLLFSHYGPVHAVQETLERSAEELRVWVDLTRRARSEGMDLDHAVAMVRDRTKERYKAMSADEATAEQFELLNGASSNVAGILHWLNRVSP
>NZ_CP017717.1|WP_080046514.1|1171706_1172237_+|single-stranded-DNA-binding-protein
MLSTATPEPPAVVPRTAFSRSGLLLIVESDLHQSTDRRTTVDRNEVLLVGRLSAPVEEHPMPSGDTVTKWRIIVRRRRNKRGVVLSDSVPCVTFNPETAAVVRTLKPRDYLEVTGSFRCRVYGPTTGKTWRYEVEVSTAKPYEAEPAIPPTPAADADPTMLAALIPRQIPYLAPTG
>NZ_CP017717.1|WP_155129507.1|1173209_1174634_-|DUF1015-family-protein
MTLAWADTTNLSAARSPDEATAPGPQPTQQPGQPHFRPDPTSPTGETPIDPRYAAARDTLREWLDSGVLVPDDVPALYVYEQSGPGVLQRGLIGDVGLVDPGQRIILPHEDVFPGPIADRLALMSTTQANLEPIFLLYDGTDGTATRLVDEVASTRHPLVSANTEDGLTHRLWAITAPDEIAAINADLHARQALIADGHHRYATYRVLQRQERATHRTTSQPPETSAPQHHEHGSHLAPHHHEHSFRPASERPADGDASSPSPENGEPTFDSGDFGQAPEYGESASGPWDFGLALLVDSRAYPPDLQAIHRVIEGLPPAEAVSRAKSSWQVHDYKDLATGLAALEQASEPAFLLAGEDGAHLLTDPDPVQLARAMPPDHSDRWNSLNTSVLSEFVLPVVWGMRDNDQTVRIVHHDTEAAVRLAIQTGGTAVILKPLAVDDVLAIAAGGERVPRKSTSFGPKPRTGLVLRTFATD
>NZ_CP017717.1|WP_080037040.1|1175309_1175732_+|tetratricopeptide-repeat-protein
MGQDGNVHDEGAGAPQGGVYDWYQRGVKLLKEGSPAAAAALLERAAAAEPESRSILEALARAQFNSRQYAEAAASFRQIVDANPAEDYAYFGLGLALWRTGDVEGAQEPLAIAVAMRPDERNYVTALKSVRATLRARREM
>NZ_CP017717.1|WP_080037041.1|1175897_1176338_-|hypothetical-protein
MPENLTLTPETRTEPSGDFDPDAHAAEAEQRWGGTDPWAEAKRRTSSYTKEDWKRFKAEAADITARLADALRSGAPSDGDLAMDLAEEHRAHISRWFYECTYKIHRGLGETYVTDPRFTASFEATAPGLAAYLKSAIAANAARHNA
>NZ_CP017717.1|WP_080037042.1|1176416_1177388_+|HAD-IIA-family-hydrolase
MLIDGYDTLLLDLDGVVYLGSHAVPGAPEALEEARRHGVRLAYVTNNASRTPAAIAAHLRELGAPATAEDVVTSAQAAARLIAERVPPGSKVLVVGGSGLRMAVRRQGLRPVSTAAESPVAVVQGIAPGLSYGLLSEGALAVRQGALFVASNADSTMPTGRGELPGNGAMVRVIAHATGVEPIYAGKPDPPLHRESMIRTGARRPLVVGDRLDTDIEGASNARVESLLVLTGVATAADVLTAEPRHRPTYVGEDLGALLQPYPEVRDGACGGWRAEWRDGVLRLDGEGSRIDGLRAACAAAWAAAGEGRVEEDAVKPVLERVG

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Crispr_ID: NZ_CP017717_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_5

1366664-1366851

Orphan

Consensus_repeat	Method
GCACGGGGCGGTGCAGCCGCCCGCCCAGG	CRT

3 spacers

The CRISPR arrays of NZ_CP017717_5

>merge|NZ_CP017717|5|1366664-1366851|CRT
CCACGGGGCCGTCCAGCCGCCCGGCCCCGGCTCCGCCCAGCCGCCTGGGCACGGGGCGGTGGAGCCGCCCGCCCAGACCCCTGCCCGGCCGCCCGCACAGGCCTCTGTGCAGCAGCCGCCCGCTCAGGGGCCGGGCCAGTCGTCGCAGCAGGAGCCCGCGCAAGGGGCGGTGCAGCCGCCCGCCCAGG

>NZ_CP017717|5|1|1366664-1366851|CRT
CCACGGGGCCGTCCAGCCGCCCGGCCCCG	GCTCCGCCCAGCCGCCTGG
GCACGGGGCGGTGGAGCCGCCCGCCCAGA	CCCCTGCCCGGCCGCCCGCACA
GGCCTCTGTGCAGCAGCCGCCCGCTCAGG	GGCCGGGCCAGTCGTCGCAGCAGGAGCCCGC
GCAAGGGGCGGTGCAGCCGCCCGCCCAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080037188.1\|1360669_1362100_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP017717.1\|WP_080037197.1\|1373031_1373673_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319972
NZ_CP017717.1\|WP_080037191.1\|1364446_1366285_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP017717.1\|WP_080046528.1\|1371707_1371965_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080037186.1\|1358170_1359925_-\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NZ_CP017717.1\|WP_080037184.1\|1355783_1356344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080037199.1\|1375167_1376661_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NZ_CP017717.1\|WP_080037189.1\|1362211_1362820_-\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_CP017717.1\|WP_155126603.1\|1368003_1368492_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080037183.1\|1354805_1355768_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|381602
NZ_CP017717.1\|WP_080046526.1\|1368554_1369187_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225462
NZ_CP017717.1\|WP_080037185.1\|1356340_1358053_-\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|197753
NZ_CP017717.1\|WP_080046527.1\|1369410_1369752_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP017717.1\|WP_080037196.1\|1372269_1372584_-\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NZ_CP017717.1\|WP_080046529.1\|1372683_1372896_+\|dodecin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377810
NZ_CP017717.1\|WP_080037190.1\|1362831_1364304_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NZ_CP017717.1\|WP_080037198.1\|1373794_1375171_-\|peptidase	unknown	unknown	gnl\|CDD\|223389
NZ_CP017717.1\|WP_080037187.1\|1360004_1360607_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225239
NZ_CP017717.1\|WP_080037182.1\|1352911_1354768_+\|Tat-pathway-signal-sequence-domain-protein	unknown	unknown	gnl\|CDD\|277344
NZ_CP017717.1\|WP_080037195.1\|1369883_1370873_+\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080037188.1\|1360669_1362100_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.48778e-95
NZ_CP017717.1\|WP_080037197.1\|1373031_1373673_+\|hypothetical-protein	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	1.56359e-40
NZ_CP017717.1\|WP_080037191.1\|1364446_1366285_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	2.96803e-164
NZ_CP017717.1\|WP_080037186.1\|1358170_1359925_-\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	6.59165e-142
NZ_CP017717.1\|WP_080046526.1\|1368554_1369187_-\|NAD(P)H-binding-protein	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	2.83512e-43
NZ_CP017717.1\|WP_080037199.1\|1375167_1376661_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	4.17942e-88
NZ_CP017717.1\|WP_080037189.1\|1362211_1362820_-\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	7.82458e-48
NZ_CP017717.1\|WP_080037183.1\|1354805_1355768_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|381602	cd13399, Slt35-like, Slt35-like lytic transglycosylase. Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).	1.38904e-25
NZ_CP017717.1\|WP_080037185.1\|1356340_1358053_-\|histidinol-phosphatase	gnl\|CDD\|197753	smart00481, POLIIIAc, DNA polymerase alpha chain like domain. DNA polymerase alpha chain like domain, incl. family of hypothetical proteins.	6.09122e-07
NZ_CP017717.1\|WP_080046527.1\|1369410_1369752_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	5.7121e-34
NZ_CP017717.1\|WP_080037196.1\|1372269_1372584_-\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	2.23361e-20
NZ_CP017717.1\|WP_080046529.1\|1372683_1372896_+\|dodecin-domain-containing-protein	gnl\|CDD\|377810	pfam07311, Dodecin, Dodecin. Dodecin is a flavin-binding protein,found in several bacteria and few archaea and represents a stand-alone version of the SHS2 domain. It most closely resembles the SHS2 domains of FtsA and Rpb7p, and represents a single domain small-molecule binding form.	3.83257e-31
NZ_CP017717.1\|WP_080037190.1\|1362831_1364304_-\|MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	2.24254e-135
NZ_CP017717.1\|WP_080037198.1\|1373794_1375171_-\|peptidase	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	2.63506e-42
NZ_CP017717.1\|WP_080037187.1\|1360004_1360607_-\|hypothetical-protein	gnl\|CDD\|225239	COG2364, COG2364, Predicted membrane protein [Function unknown].	2.95991e-37
NZ_CP017717.1\|WP_080037182.1\|1352911_1354768_+\|Tat-pathway-signal-sequence-domain-protein	gnl\|CDD\|277344	cd07399, MPP_YvnB, Bacillus subtilis YvnB and related proteins, metallophosphatase domain. YvnB (BSU35040) is an uncharacterized Bacillus subtilis protein with a metallophosphatase domain. This family includes bacterial and eukaryotic proteins similar to YvnB. YvnB belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.65366e-79
NZ_CP017717.1\|WP_080037195.1\|1369883_1370873_+\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	1.30912e-177

>NZ_CP017717.1|WP_080037191.1|1364446_1366285_+|long-chain-fatty-acid--CoA-ligase
MGEVLEVRAEIERQIAGRTVCEQLARAAEEHHDAPAYSDPEGDGWRTLTYGQARERVLEIAAAFVALGLEPGEAVALMMVNRSEHVLADLGAVHAGGVGCTVYSTFAPDQIAFVAGDVGARYAVLGGPADLARWEPVLDRLDGLRRIIMLDGAPAGDRFMAWDDFLALGRERLAADPAQVETRLRAVAPGDVATVLYTSGTTGTPKGVPLTHANIFYEVAATDRLTALPMRGTQISYLTYAHIAERILSLYLPLVKVSHVHFCTDLANLGATLGQVRPMMFFGVPRVWEKMMARLLAVLATQPEEQQAAVREAMAAGVAYVEAGQYGHTITPEIQAAYDQADASLLSIIRGMIGFDRAEWTATGAAPLPDEVQRFYAGLGLKVIDVYGMTETTGAFTGNSPACYRLGTVGRAEPGVEVRIAEDGELLTRSPLNTAGYLNRPQATAELIDADGWLHTGDIGTVDDDGFYRVVDRKKELIITAGGENISPAEIENHLKQHSLIGQALAYGDNRPHPVAVLTLDPEVAPGWAQARGITFGSLAELAEHPDVLAEVEAAVQAANAKLARVQQVKKWALLGVEWTAETEELTPSLKLKRRIIHTKYADIIEGLYGRP
>NZ_CP017717.1|WP_080037190.1|1362831_1364304_-|MFS-transporter
MTDRTFFGHPRGLATLFGTEMWERFSWYGLRAILATFMAASPAHAGLGLSQETSQAVVGVYGALIYLVALPGGWIADRILGARRSVFWGGFVIMLGHISMAIPVTSSLFVWLGLLLIIAGTGLLKPNISVMVGRLYPEEDDGRRDAGFSLFYLGINLGAFFAPLVVGWLAEGDRWHLGFSAAAVGMALGLVQYVLGGRSLRGVGEWPGLRLTPRERRRFGRLVALGVVLTLVVLGAWAATGTLTVDRFTVALTLVILIVPVAYFGYIMFGSHDLTEDERIRMKAYIWLFVAAAIFWMIYDLAPSKLLFFAQDHTDLSLFGIRINQATTQSFNPLFIMIFVPVFAALWVRLGTRVSTPQKFGFALVMVGLSFVVMAVAAGLAGAGRVSVWWLVLVYLVQVFGELSLSPVGLSVTTKLAPEAFKGQMLGIWFIAVSVGDAVGGQTGRLGRVLSEPMYYLVLAAMAIVAGLALFLFTRSLRVMMAEHHEPAMR
>NZ_CP017717.1|WP_080037189.1|1362211_1362820_-|trimeric-intracellular-cation-channel-family-protein
MSELLDLAGIFVFALSGALMGVRKRLDVVGMGVLAEITALGGGVVRDLILNVRPIAFQSLGYVLVPVAATVIVFFWHPHVARVMPAILVLDAAGLGLFCAVGTEKAMEYGLSPLHATLLGVTTAVGGGMLRDVLAGEIPTLLYDRQLYAVPALLGSGVMAGLSSYGLHGWPATLAAALLAFGLRIAAMRRKWRAPLAKGIGE
>NZ_CP017717.1|WP_080037188.1|1360669_1362100_+|PLP-dependent-aminotransferase-family-protein
MRHMSATQVARLIDVDPAARPYYRALADGVRALIMDGQLPVRVRMPAERHLAETLKVSRTTVTAAYDLLREGGYLESRQGSGSWTALPDPAVWPDNPWLGTDRDGLIQLHTAAPAAPAALLAAMTAAVEDLPRYGMGNGYDPMGLPSLRDRIAARYTARGVATRPEQIVVTTGAQHALHLVMGLLVGPGDAVIVESPTYPHAIDAARQRGARIVPVGVSHDGWRPDLVAGAMLQSGARLAYLMPDFQNPTGALMPDPVRAAVAGAARRAGTLLLIDETWSELALDDVPRTSPMAAFDTDSRVISIGSASKLWWGGLRIGWIRATAALARRLTTLRSSVDIASPVLEQLVVARLFDRLEETRAERRRTLRASRDALAAHLRAHLPEWTFALPSGGGALWVRLDGAGSTPLTEAALSHGVRLAPGPWFGLEGTLEGHLRLPYTQPPTLLADAVQRLRAARDHGPTGAPRPPDQLIAMV
>NZ_CP017717.1|WP_080037187.1|1360004_1360607_-|hypothetical-protein
MSETTVPLPSSLPARLVRLYGGLALYGLGIALQVKSGLGNGPWNVFHEGAALRTGLTIGTVILVVGALVMLLWIPMRQKPGLGTISNVLLVGPFADAAVFLLPTPEHLAFQTFYLVMGVVTIALSTLLYIGAGMGPGPRDGIMTGLVRLGLSVRVARLSIEVAVLIAGWLLGGTVGLGTVVFALAIGPLTQLFTRWFPLT
>NZ_CP017717.1|WP_080037186.1|1358170_1359925_-|glycoside-hydrolase-family-15-protein
MRIEDYALIGDMQSAALVARDGSIDWLCLPRFDSPACFAALLGSERNGHWWLGPTGRKPATRRRYRPDTLILESEWDTPTGTVRVVDFMPPRDRNPDVVRIVEGVSGSVQVSTQLRVRFDYGRIVPWVRRTNGHLQAIGGPDSVWLHSPVPLKGGDYAHRATFTVNEGDRLPFVFTWHPSHEPMPPQIHCDTQLGETEAFWAEWVARCTYSGPYREAVVRSLITLKALTYAPTGGIVAAPTTSLPEDLGGVRNWDYRFCWLRDATLTLDALISSGYLEEAGDWRAWLLRAIAGRPQDLQIMYGVAGERRLPELRLDWLDGYEDSRPVRIGNEAVKQLQLDVYGEVMNSLYVSRTRGLSADDRAWTIQRQLLDYVEDHWHEPDEGLWEVRGPRRHFVHSKVMCWAALDRAVKYVEHFGRTGPVDRWRALRDVIHAEICDKGFDPRRNTFTQSYGSSELDAALLMIPMVGFLPADDPRVVGTVAAIEKELMSDGFVLRYPIAEDNDVDGLQGGEGAFLACSFWLVEVMAMQGRKEEAKDLFERLLALRNDVGLLAEEYDPRYGRLVGNFPQAFSHVPLVHAARALS
>NZ_CP017717.1|WP_080037185.1|1356340_1358053_-|histidinol-phosphatase
MGHGHHHHDHEHDHEPAGDTDASVARDLSVPDGELSPGQLSRRRMFRRAGLLGAGLTAAGVLGGEGQAAVAATGRDEGRGREPRDGYQWLAGDHHIHTQHSSDGVYRVIDHVRHANAYGLGWMVITDHGGATHAKIGVEKVNPDIVAARAAVKDTLVFQGLEWNIPAAEHGTVFVAPGRNEVATLKEFESSFDGSVKGASSNTPQNEALAIAGLNFLADAVRKRRVPDALFFANHPSRKGIDSPHEIRGWRDAQPTIAVGMEGAPGHQAAGIAKPNGPGGGRGYYDSNPGADSFPGYPAESYKTFGGFDWMTATVGGLWDSLLAEGKPWWITANSDSHWVHGDTSDRGPGGDFNANGRYEDPVYKGVPNFGSGDFWPGFYSRTHAGAEDFSYRAVMDALRAGRVWVDHGGLISGLVVRARPAGTGQRGVTLGGTLQVRQGARVELAIEVTLAGRPNWAQFVPTLARVDVIQGDVTGPVSDKDAFTTPNTKVVQSYEVNRSTGTVTFTYQLGAVDRPVYVRLRGTDGKRSAPGLLGAAVDPNGPRIDVYGDADPWNDLWFYSNPIWVLPRR
>NZ_CP017717.1|WP_080037184.1|1355783_1356344_-|hypothetical-protein
MIAGFDAGSRTVPEAEHLLHTVVRELGLPGDTIGCTHFVPAGAAGDEPHVACSLAVPDSVTPAALSAALSAALSAALPAGWSAEGAALAVAEHEARRGGRVVTFPGRDRLTGVLRVGELRDASAIDRVLLLASPGPPPDDVLVVTNDHVRPVWRDGLMTLLTMPAAGGRITPAEVPNPTPCCADHA
>NZ_CP017717.1|WP_080037183.1|1354805_1355768_+|transglycosylase-SLT-domain-containing-protein
MEARQKHPHPPRPARAAAAPAGKAAALVLGAVVLLGAAACGPAPAAAPPAPAPSTPAPSTPKPSEKPLPDPTEKIPDSPAKLAAALRETTDALNASIDAWTKHGSPATGEPPEDVELLALHQQRIYRHAARHPDLAAKTFARLPAALAAQARDDTAAIRELLALARPIKPDAVFKTQPARPAGELLGYFKKAERRFGVEWEVLAAVMFAETKFGRVRADSHAGAQGPMQFMPATWKAYGMGGDVRDPHDAIMGAANYLKASGAPRDYRRALHAYNPSQAYVNAILLHARRIKRDPRAYYAYYTWQVYVITTEGERRLTGP
>NZ_CP017717.1|WP_080037182.1|1352911_1354768_+|Tat-pathway-signal-sequence-domain-protein
MAHPTLGRRALLTAAVAAPAAGALAGPAASPAHASGNGGRFDRESPRFTIGVLPDTQYLFDEDRSDPDPVRQTFRFLTGGERESRNIAFMTHLGDVTEHGTQEELALASDTFRQLDGRLPYSVLAGNHDVSGADDQRGDSAYLKAFGPSRYARMSTFRGASPDGYNSHHVIEAGGRRWLVLALDWRVSDQGLRWAQSVIDANRTLPAILTTHDLAWADDTGAAALSQHGQRLWDAFIKRNDQIFLTLNGHYWPSGRTVLKNDAGHDVHVHITNYQDRYYGGAGMVRLYAFDLVRNVIDVETISPWLLERDPDERTPLEAEHLELTGPVDRFSIEIDFDERFAGFAPRTPPPARPARAVMPRGTVAYWRFDAEGLAGAAGTDGAIVPAGTVARDLTGGGNDLTMELLHASAPETLTWSAEHHEGQPAHASLRFDGGKSPDRGAVLRSGPNAPVNSMTFTSGYTIEAFIKLPEPFEGDHAWMGILSWEGRSGDAGKSSGWSPDEPTCSLNLSPERFLQFVVYPTDRDADPTSWSHALPVGRWTHVAVVNDSRRTIMYVDGSKIARNPSQRSKGISTLGRPFAIGGTQFALTYGQGFYGWIGDVRIVSRALRPKEFLRPYA
>NZ_CP017717.1|WP_155126603.1|1368003_1368492_+|hypothetical-protein
MRRLAAGLAAAALGATVVATAASPALADDPGLDPDVAGGHTSLKLDVNPEPAWRGKPLTIEGKLSVECDEDYISGFVSVHHADYCKKQETWHRLAYKRVVILFQANGSGRWEHVETVRTSGKGYFGLRVPARESGTWRAVFEGSRHLEPSEGTDWVKVIGRH
>NZ_CP017717.1|WP_080046526.1|1368554_1369187_-|NAD(P)H-binding-protein
MFGAGGRAGANVVAEAAGRGHEVTAVVRDPARYPELGGPGVRVVAGDVTDGGSVRAAAAGHDVAVQVAARLDMSSEEFYTAATRALVDGLGRAGVSRLVALGIGTLLEVSPGVRLIDTPGFPADARAFSLGHAAELELLEASELDWVVIAPPPVLLDEKAARTGRYRFGDGRVPQAREGDPVFSFADLAVAVVDEVESPAHHRVQVAVSS
>NZ_CP017717.1|WP_080046527.1|1369410_1369752_+|helix-turn-helix-transcriptional-regulator
MFTGCPPVTAPIRIGDKWTAKIIRCLERGPRRFTELQTPLRGITPKVLTESLRAMERDGLLTRTAYDEIPPRVEYELTDLGRSLLEPMNAGCEWSRRHLPELIAARDAWHAAP
>NZ_CP017717.1|WP_080037195.1|1369883_1370873_+|GTP-3',8-cyclase-MoaA
MLRDSFGRVATDLRVSLTDKCNLRCTYCMPPEGLDWLPSAQLLTADEIVRLVTIGVERLGIKEVRYTGGEPLLRRELVDIVGRTTTLTPEPQISLTTNGIGLARLAEPLAAAGLHRVNVSLDTLDPATFKRLAHRDRHADVIAGLAAADAAGLRPVKVNAVLMRGVNDHEAVPLLRWCLDQGYELRFIEQMPLDAQHGWSREGMVTADEILQLLSASFDLTPDDVEERGSAPAERFLVDGGPARVGVIGSVTRPFCGACDRVRLTADGQIRNCLFATEESDLKTPMRDGASDEELAERWMAAVSRKRAGHGIDDPSFLQPSRPMSAIGG
>NZ_CP017717.1|WP_080046528.1|1371707_1371965_+|hypothetical-protein
MHVLNEWTALACKELGIDPATVDRDQILDLTKEVAHGVARPAAPLTAYLLGLAQGAGTAPEDAVARLTTLAKNWSEATTETLTDG
>NZ_CP017717.1|WP_080037196.1|1372269_1372584_-|DUF3099-domain-containing-protein
MKGWRRKPDVHQVTDARPSLTADIRKREVSYLIKMGIRTICLILAVVVPVPWPYRLLFIAAAVFLPYIAVIGANERDKGAPPPTFQSPEANQTEIPLHRREIGS
>NZ_CP017717.1|WP_080046529.1|1372683_1372896_+|dodecin-domain-containing-protein
MTDRTYRVTEIVGTSGESVDQAIRNGIRRASETLRHLDWFEVTEIRGHIDAGEVAHFQVGMKVGFRLEDA
>NZ_CP017717.1|WP_080037197.1|1373031_1373673_+|hypothetical-protein
MAIPPAASGPGSGAASGPASGPARGAGSGRGEFRILLVCTANICRSAMAEVIAQAMLHSAALPVVTGSAGVRALVGHPMAPHAISALDRLGLNGRAHRARLLDRDLIASADLLLTMEDAHRAVAVALDPRAAGRTFTLPEFAELAAGAGQRRYRSDTVERARAIVQSAAERRARRRPAEVHDPYGGPPEGYEACAKTLGASLSHALAALLGPR
>NZ_CP017717.1|WP_080037198.1|1373794_1375171_-|peptidase
MTPQEMVERALELSRNDGCVVLVDEGSTANLRFAGNTLTTNGVARSARLTVISIAGQGVGVVSRAAVRDEQLADVVAAADAAARDAQPAEDARPLVEAGPASPHWGEDVRPTDIGVFEGFAPALGEAFSAAEAGGRKLYGFAEHSLTSTFLGTSTGVRLRHDQPTGRLELNAKSGDLKRSAWTGVSTQDFTDVDVAALGNSLAQRLEWAKTRVDLPAGRYETLLPPSAVADLMIYMFWSSGARDALDGRSVFAKPGGGTRVGEQLATLPVSLSSDPGAAGIACAPFVTAHASGRESSVFDNGLPLGRTDWIKDGRLEALLQTRYSAELSGLPVTPGIDNLIMSGPAGGPSPSLEEMIASTRRGLLVTCLWYIREVDPQTLLLTGLTRDGVYLVEHGEVVGEVNNFRFNESPVDLLGRLTEVGASAQTLPREWNDYFQRTIMPPVRVPDFNMSTVSQAS
>NZ_CP017717.1|WP_080037199.1|1375167_1376661_-|TldD/PmbA-family-protein
MRQIDPDFLELPLRQLADAALQRARELGAQHADFRLERVRAETLSLYDTRLEGAMDADDLGYAVRVVKDGTWGFAAGIHLTPEAAAVVAEQAVRVAEVSAPINREPIELAAEPVHADAVWVSAYDVDPFEVPAADKVGLLAEWSAGLLKGADHVSARLLQVKEQKFYADTAGTVTTQQRVRVHPKLNAMKATESGFDDMSTIAPPVGRGYEYLTGTGWDWQGELARLPELLAEKLAAPSVEAGDYDLVIDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDQLGELVYGSPVMNVTGDRTVEHGLATVGFDDEGVQGQSFDIVKDGILVGYQLDRRMALMKGLGRSNGCAFADSPGHMPIQRMANVSLAAAPGGPSTEELIAGVERGIYIVGDKSWSIDMQRYNFQFTGQRAYKISHGKLDGQVRDFAYQATTTDFWQSMEAVGGPQTYVLGGAFNCGKGQPGQVAPVSHGCPAALFRGVRILNTVQEGGK

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Crispr_ID: NZ_CP017717_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_6

2552722-2552814

Orphan

Consensus_repeat	Method
CGGAGGACGGCTGATGACCCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_6

>merge|NZ_CP017717|6|2552722-2552814|CRISPRCasFinder
CGGAGGACGGCTGATGACCCTGCAGTTCCACGGATCAGAGGACGGCTCATGACCCTGGAGTTCCACGGATCGGAGGACGGCTGATGACCCTGC

>NZ_CP017717|6|5|2552722-2552814|CRISPRCasFinder
CGGAGGACGGCTGATGACCCTGC	AGTTCCACGGATCAGAGGACGGCTCATGACCCTGGAGTTCCACGGAT
CGGAGGACGGCTGATGACCCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080038138.1\|2548787_2549876_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP017717.1\|WP_080038133.1\|2541004_2544844_-\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|341253
NZ_CP017717.1\|WP_080038137.1\|2547686_2548478_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP017717.1\|WP_080038150.1\|2562374_2563055_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187631
NZ_CP017717.1\|WP_080038147.1\|2558064_2558985_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP017717.1\|WP_155126888.1\|2550704_2550812_+\|lasso-RiPP-family-leader-peptide-containing-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080038144.1\|2555418_2555856_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP017717.1\|WP_080038139.1\|2549900_2550359_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080038134.1\|2544843_2545569_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|373220
NZ_CP017717.1\|WP_080038142.1\|2553536_2553938_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274925
NZ_CP017717.1\|WP_080038149.1\|2561795_2562236_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155126894.1\|2553934_2555311_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341047
NZ_CP017717.1\|WP_080038146.1\|2556693_2557977_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080038141.1\|2553058_2553487_+\|lasso-peptide-biosynthesis-B2-protein	unknown	unknown	gnl\|CDD\|379206
NZ_CP017717.1\|WP_080038145.1\|2555970_2556618_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_080038136.1\|2546724_2547186_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|377396
NZ_CP017717.1\|WP_080038135.1\|2545579_2546746_-\|questin-oxidase-family-protein	unknown	unknown	gnl\|CDD\|372882
NZ_CP017717.1\|WP_080038132.1\|2540774_2541005_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179269
NZ_CP017717.1\|WP_155129618.1\|2559689_2561756_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293787
NZ_CP017717.1\|WP_080046653.1\|2547225_2547630_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377396

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080038138.1\|2548787_2549876_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.30795e-38
NZ_CP017717.1\|WP_080038133.1\|2541004_2544844_-\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	6.82753e-162
NZ_CP017717.1\|WP_080038137.1\|2547686_2548478_-\|HAD-IA-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.05947e-52
NZ_CP017717.1\|WP_080038150.1\|2562374_2563055_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187631	cd05373, SDR_c10, classical (c) SDR, subgroup 10. This subgroup resembles the classical SDRs, but has an incomplete match to the canonical glycine rich NAD-binding motif and lacks the typical active site tetrad (instead of the critical active site Tyr, it has Phe, but contains the nearby Lys). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.58813e-30
NZ_CP017717.1\|WP_080038147.1\|2558064_2558985_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	7.68286e-07
NZ_CP017717.1\|WP_080038144.1\|2555418_2555856_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	3.83884e-17
NZ_CP017717.1\|WP_080038134.1\|2544843_2545569_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|373220	pfam14681, UPRTase, Uracil phosphoribosyltransferase. This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.	5.17057e-86
NZ_CP017717.1\|WP_080046653.1\|2547225_2547630_-\|hypothetical-protein	gnl\|CDD\|377396	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ. DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.	1.37299e-14
NZ_CP017717.1\|WP_155126894.1\|2553934_2555311_-\|MFS-transporter	gnl\|CDD\|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.43403e-39
NZ_CP017717.1\|WP_080038146.1\|2556693_2557977_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	8.8137e-41
NZ_CP017717.1\|WP_080038141.1\|2553058_2553487_+\|lasso-peptide-biosynthesis-B2-protein	gnl\|CDD\|379206	pfam13471, Transglut_core3, Transglutaminase-like superfamily. This family includes uncharacterized proteins that are related to the transglutaminase like domain pfam01841.	7.63133e-21
NZ_CP017717.1\|WP_080038145.1\|2555970_2556618_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.38017e-45
NZ_CP017717.1\|WP_080038136.1\|2546724_2547186_-\|DMT-family-transporter	gnl\|CDD\|377396	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ. DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.	6.75506e-23
NZ_CP017717.1\|WP_080038135.1\|2545579_2546746_-\|questin-oxidase-family-protein	gnl\|CDD\|372882	pfam14027, DUF4243, Protein of unknown function (DUF4243). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 348 and 477 amino acids in length.	9.17075e-37
NZ_CP017717.1\|WP_080038132.1\|2540774_2541005_-\|hypothetical-protein	gnl\|CDD\|179269	PRK01271, PRK01271, tautomerase PptA.	4.66221e-22
NZ_CP017717.1\|WP_155129618.1\|2559689_2561756_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|293787	sd00044, HEAT, HEAT repeats. The canonical HEAT repeat consists of two helices forming a helical hairpin. HEAT repeats are found in a diverse family of proteins, including the four proteins from which its name is based: Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A (PP2A), and the lipid kinase TOR (target of rapamycin). The HEAT repeat family is related to armadillo (ARM)/beta-catenin-like repeats.	3.48406e-06
NZ_CP017717.1\|WP_080038142.1\|2553536_2553938_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274925	TIGR04023, Pyridoxamine_5'-phosphate_oxidase, PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. This subfamily within the PPOX family occurs in at least 19 distinct species of F420 producers and is likely to bind F420 rather than FMN. The member OxyR was shown to use F420 to catalyze a C5a-C11a reduction in oxytetracycline biosynthesis. [Unknown function, Enzymes of unknown specificity].	1.3827e-43

>NZ_CP017717.1|WP_155126888.1|2550704_2550812_+|lasso-RiPP-family-leader-peptide-containing-protein
MQRYEKPRLTPAGTFRKATGLLSRHGNDRLILSKN
>NZ_CP017717.1|WP_080038139.1|2549900_2550359_-|hypothetical-protein
MSVGRLLSILAAALLPVSVLVSPAQARTAVPFHAALSGCPGAITEGTLEWVGDEVVKVEGNAAKYMPFPSCTRQSGLHSVAFRAYNGGTKTAEQAFWLLSDRLDVSLELTAPQGTPIDGVTVQICEFRVGLPGSIPPSSLLCLAPVRYQSPM
>NZ_CP017717.1|WP_080038138.1|2548787_2549876_+|serine-hydrolase
MPKSLAVVAPLAAGCLLLTLVVPAHAATATPSPQSSLDLLTTTDGMAGALSRVRDPSGTSVTRRSGTAQRGSGKPMIGPEGRFRIASGSKPIIAATVLRLADQRKVDLAAPVERYLPGVLRGTGDGAGIDGRKITVRMLLRQTSGLPEFLDAIEWKEPFPDFLRVALGRKPTARGSFAYANTNYLVLGMIVTKVTGKDFRQASRELILKPYGMRDTYWPAKGDHGIRGPHARTYGVHPGHPQDGEVDLTDRLPTYAFGPSGGLVSTPEDLNRFWRNAPLSRMMAGPVKVEQEGWPAGARYGFGVIRMRTGCGDAYFVAGDMPGAAMISGRDRAGRAATVYTTGVPKNRQHLLDAFVTTLCDR
>NZ_CP017717.1|WP_080038137.1|2547686_2548478_-|HAD-IA-family-hydrolase
MTQLTVFDLDGTLVDTPRAIVETFTAAFGALSVAAPPPAVIRATIGLPLERAFRDLLAADAELAGQGVRHYQRLFKEIILPRAPELIFPGVVEGLDELRARGGLLAVATSKFHASADALLRAAGLRDRFALVVGADQVSRPKPDPESGLLVLRTLGVAARHAVMVGDTAHDIHMAGAAGMRSIAVTYGVHGADELALAGPTWVADSFPQVVALLLSREAASHAQPAHGAEPAPRAEPARDAEPASRAEPVPRAEPASRAEPVW
>NZ_CP017717.1|WP_080046653.1|2547225_2547630_-|hypothetical-protein
MTQANAVLAGHTGPLYASWAAHGLGAVVASVLVLALARRAPATASGEGEGRAPLWYYLGGIPGALVVVLSAIAVNSELALAGTIALMLTGQILFGTLSDHLGLLHTPRRRITPMDLAVAGCVLAGSVLIVVGGA
>NZ_CP017717.1|WP_080038136.1|2546724_2547186_-|DMT-family-transporter
MLFFVVLALLNGVLIGTSRTVNGRLSTRKGAFRASVWNHVVGFVFLSVVLLVLRAWPDVTDAPVAAYAGGVFGALFVAVNSYVFPRLGAMSASVLVISGQVLSAVIIDCVQHRALPAPIRLAGVVLVLLGLGLPRLSARLRQREIHPCPTEKK
>NZ_CP017717.1|WP_080038135.1|2545579_2546746_-|questin-oxidase-family-protein
MPDREEVIDALLDDRTYHIEFNGHLTNHAKHAVVALAGLGVPAADIKAYYDAYAKLTSYGFGLEAPKPDRHLITERNWREHLGQRTSFWSYCDFFDRRERELGLAEVLRRYVPELLPGWTGSFTHATIHLGWALDAGHRWMAIEGLAYLAFSYSTCHPERARPPREDGAPVDSLLRLAGVWDEHRDELTHWVAGLLADTSPVEDGRIHPELLRSGLQFRIARTLSEGHPLFYDTPAWTRDDHWEPLYYAVTLLYLARPGDFVLLHLITSLYAVERIAEHLPAEQWRQAAVCFWIGLLGTVFSGADFPHRAKLAALHRLFSEAVDEDARDWDTIVGRAVLEEEEHNPKLVYVLRRVWERAGRRSIYRVAAGQFTATPELPPSFDEPPTA
>NZ_CP017717.1|WP_080038134.1|2544843_2545569_-|uracil-phosphoribosyltransferase
MPAQHNLHLLPQTRQLRALHTVVRDRHAALDTFVLHSRRIIRLLLEAGLDQLPFTEHHVTTPVGATYRGLRHAADICAVAVVRAGESMEAELRDLHPGIRIGKILIQRDKQTKLPHLYYSHLPPGIADSHVLLLEPMLATGGSANAAIDVLIKAGVREEHIVLIDFIAAPEGIRAVTEAHPHVKIVVSSIEERLNDDAFMIPGIGDFGDRYFGTTHPSGTSASRDTTDHTRTTFGTTDPGA
>NZ_CP017717.1|WP_080038133.1|2541004_2544844_-|amino-acid-adenylation-domain-containing-protein
MITVPSARPAATRTRVGVGACLPDLLLQQAENRPDAVAVTGAGGSLTFRELLHDAGRLAARLQRLSAGPDDCVGLYADPSADLITGVWGILMAGAAYLPLSPDYPPDRIRFMIEDSRATVVVTQPHLVREVSELAPPGTRIVTLAEEPRLEADGERRPGEAAWGPGSLAYVIYTSGSTGRPKGVLIEHHSIASQLRWMHTCGHIGPHTTVLQKTPASFDAAQWEILAPAFGSRVVTAPAGGHRDPDALIDAMAAHDVTTLQCVPTLLEALVDTGRLARCTALTRVFSGGEALTKRLARAVFAALPGASLINLYGPTECTINATAHVVDPCQAADGDGTLPIGVPVDNTHCFVLDANLAPVDIGETGELYIGGAQLARGYLNRPEQTRERFVPSPFVPTQRLYRTGDLAYWNPDGTLQFAGRADDQVKLRGHRIEPGEVALAAERHAWVRRAAAVVVTDERTRTPQLVVCAELDPREAALMDQSHHAAHHRSKADRLQVRAQLAGAGLRPDLSGRPAVPLPHRDEPAELRRAVFARKTYRFYEGGPVTRADLLALLGPTPGGTDVRRSGPLGLDELGRILRWFGQFRSEQRLLPKYAYASPGALYATQLYVEAAGVTGLAPGLYYYHPADHALVHIGAARLPKDGGLRVHLSGRRAAIEPVYRENLHEVLEFEAGHMVGVFEDVLPAYGLDIRPLDRIASVRERLGVEPHDHYVGTFEIGPHDGSPRAGDVEVFVQAHAGRVPGLPAGFYRHRDGTLERVSDEVVQRRHVVAINQQVYDRAAFGLALLARDGRPWLAYVVLGARLHHLQRNALGLGLMSSGYSSKSGHPMPAARRVAEILAGTGAGTQAMYFVLGGRVSAEQIAGEDMREDAVHMKGPAELIKDGLARLLPDYMLPNRVLIVDALPLTANGKVDAAALRALAAPRPAAPHVPPATATERWLAAEWGRVLKYEDVSATDDFFACGGNSLTAVALINRINREFGTRLPFQALFESPRLTELAARVDAGQAAPSSRLVPLGHATDGSPVSHGRAAQGPPVFCWPGLGGYPMNLRALARHAAPGRPFHGVQAYGLNPGEEPYPSIQEMAAADVAEIRRVRPRGPYTLWGYSFGARVAFEAAKQLEQAGERVDEVVLICPGNPRVAAGSRERAASYTDPTYVTILYSVFTGTVAGPGLERCLEQARDEESFVAFVHGLLPELDRPLIRRIARLVARTYAFPYPFDGLAAPVTVIRAAGDEQPHIDGKVFELAADHYGALREPGVAELAHTIRTSTNVIRTSTEES
>NZ_CP017717.1|WP_080038132.1|2540774_2541005_-|hypothetical-protein
MPHVTIQHFPLDLAPERRRRLADALTALVVEEFGTYEGAVSIALEPVDPGDWAAAVYEPRIAGRPEQLIKAPEYRR
>NZ_CP017717.1|WP_080038141.1|2553058_2553487_+|lasso-peptide-biosynthesis-B2-protein
MSVPSALERPQGVPWRARAAARVAVAAAFVLALLPPNRLRAVLRLLRHGARPATYAQAKAARDAVLAVSLTCLGVHGCLPRSLATTVLCRLRGSWPTWCSGVRMRPPFAAHAWVEAEGTPVEETVPDGYLTPLITVGPRHEG
>NZ_CP017717.1|WP_080038142.1|2553536_2553938_-|PPOX-class-F420-dependent-oxidoreductase
MSVFSERELAYLRGERLLGRLATVGADGLPHVVPVGWSLDGTGTLIEIGGRNLVRSRKFRDIARNGRAALVVDDVLPPWRPRGVEIRGTAEAIDGDRPLILLRPARIVSWGLHDGATIEDTYRARAAGRPVDP
>NZ_CP017717.1|WP_155126894.1|2553934_2555311_-|MFS-transporter
MPASPRQVVTALVTTVFGYSLMQTVVVPALGLLTRELHTTPAWSAWILSAFLLSSAVLTPLLGRLGDLYGKRRVMIGVLAAYAAGMAGAALAQDIAQLIAARVVQGAALAVVPLSMAVLREALPRERLASAMGLVSGIVGAGAGAGLVVGGLLADRLSWRYLFVLGALLALISLVMVARWTPRGARAAAGGLDVPGSLLLALSLVAVLLALTQGPSWGWGSAPVLGLFVLGALLGAALLTLERRRTDALIDVAELTDRPMLATHLAALLFGAGSYFFYVAIPLFAQQRPGPDGAGFGASVTVAGLLMLPGMLAIIPAGMAVGRISQALGSRWPLAAGFVAMAAGSALIAVMHGAYWHHLVFYGLVGAGSGLVMGALPKLIADIVPPARTGTANGLNNIARTVGGVVGSQLAAAVIASGGAAAVPDSAFTALFWLAGGVAVLGVAISPYAVRALRTAAA
>NZ_CP017717.1|WP_080038144.1|2555418_2555856_+|winged-helix-turn-helix-transcriptional-regulator
MKSETGAPAGLGFAATLVRMSHLVQHVFADVSRERDITPQQAQLLCVLTSGDGIGMTDLSRLLHLEKPSLTGLVDRAERRGFVRRVRDDADRRACRVELTPEGLDLAVRVHAEIVGRLDALAADLPGEDVLRVADTLTALLARTP
>NZ_CP017717.1|WP_080038145.1|2555970_2556618_+|response-regulator-transcription-factor
MRIVIAEDDPLLREGLALLLRAEDLDVVATASDAAGFLDAVDEHAPDVAIVDVRMPPTHTDEGIVAAVEARRRRPGLAVLVLSAYVEQAFATDLLARGSARLGYLLKERVGRVEEFLTALHRVADGGTAIDPEVVAQLLTRSRPDNRLERLSPRERDVLALMAEGLGNSAIAERLFVTDGAVHKHIRNIFAKLDLAPADGTDRRVAAVLRYLEGT
>NZ_CP017717.1|WP_080038146.1|2556693_2557977_-|sensor-histidine-kinase
MTAGEGRAQRRSRLRWPRRADVLARGRVTLDALEHLVAGMGTGVLALVALVSAALTAVACLVGVGLAVVPAAVRGVRAVTDRERARIARWDGEEFVPPPPPPSGVRAALADTTVRRELGWVVVHASAGLVLGLAALTLPLHAVQDVTFALWWWLLPPEEAASAAYGMWEVRDTAGAVAVAALAPVEIAITMVVAPRMARLQAWAGRRLLRPGPDADLSLRVAQLTATRAAVLDAHAAELRRIERSLHDGTQNRLVAVNVLLGAALRALDRDPATARATLERAQDAAEQALGELRGVVRTILPPVLADKSLADALTGLAADCPVPCRIDADLPVRAAASVEATAYFVVAEALTNIARHSRARRAVVTVRRLDDQLVLRVVDDGQGGARESGSGLAGIRRRVEAHDGSFTLTSPAGGPTTLDVTLPCGT
>NZ_CP017717.1|WP_080038147.1|2558064_2558985_-|CPBP-family-intramembrane-metalloprotease
MAVNSPPITEQGRSRTGLRGFIQHRPLISFFVLANLMSWVAWLPYILSQNGLGILSFRFPSLLGTTQFLGVLPGAYLGPIFAAYLVTRVSEGKEGVRRWVRRMTKWRVSWVWYLVTALGVPAVIVVTGLAMTDGQVSVPPVAVLVAYVPGLLLQMVTTGLAEEPGWRDFALARMQRTLGGLGATVVLGPLWSLWHLPLFLTEWGGWPDVTWTRVGEFAAFCCAFSVVVTWVFNRTGQSLPLVMLLHVSVNNFMSIAYSDVFPTLATPALASRVTLLAGTTAAVVVLVATRGRLGYRPPAEPDPQDL
>NZ_CP017717.1|WP_155129618.1|2559689_2561756_+|HEAT-repeat-domain-containing-protein
MACMFEGLHDIDWASMEHAYGPADEVPELLLALRSPDREERHKALSRFYSAVHHQGVVAPCTTASLPFLFELAGDPTVPERAAIVELLVSIGRAAVEECEEEYADLVDFAGAAAVMRERAEAFVAFAADADQHVCRAAIPGLGLFLDDAERAGVVLRDRLSAEPGMVERLLIVEAMGTLALRLPASADEVMTGLAGLAADVTVDPGVRLAAVVQQARRAPEQIGEDVVPAVIALLRQMVLGAAAYPVWRESTGQVSPADGAPPQVATAFEDLDRLGRVHAPTTELLRTLHEALAARVPERTALLTEQLAGPDPGSRLDAIRMSKELMTSWRGDHTGLITLVAGQLSTREHEIAAEAAAVLESCHPIAEPAREPLAAYVAAYGPDTWSAPQQQLRRAYQSAVRALARIGDGRAVPGVLAGLDGGVDDWRAVEVAGALREASQKLVPRLCDQLRRIDHAQQRLEMSAGSVLSALTGLGDQAALAVINDTLLAAVRHERKSTICSALKALAAFGPAAAPALSGIRSLTAASDAHVRHAAVGALWAVSGDQEEVLPLLHDLLGSSVFFWKTLAADVLGEIGPPATAALPRLRELLTDTYEWVRVHGATALWEIGGEAETRPVLDTLLQAWEQNPATANHVVACLDRMGPAAAPALPRLRSELVRARRGGRFASIDNDEELQRISRVIVERLA
>NZ_CP017717.1|WP_080038149.1|2561795_2562236_-|hypothetical-protein
MTWAQILPLLQDVWGQGTDVGRHVLTTLLAALDSIGSNWSDWRARQIGVRRDEPPAVEVRAMALAEETAQDGRQRAVDHPGADLEELQRLRLVLRQAICASPGQTALRHVRPWLWSLTTSGGHALTASGQDTGFELRLSRYQKPVC
>NZ_CP017717.1|WP_080038150.1|2562374_2563055_-|SDR-family-NAD(P)-dependent-oxidoreductase
MPTLAIVGAGPGMGLAIARTFGSRGFDVALIARTKEKLETLAGRLGQEGITAAAFPADLLDPASLTDALDAAKARFGGIDVLEYSPAPHSPVPGLTMVAPSEVTIGNLQPMIEYAFYGAVTAAQAVLPAMRAAGAGTLLFTSGGGSVDPLPMFGNANAAQAALRNWVINLNKELAGSGVHAAHVAINVWIGGGGPEGSPTATPEQIAPLYWDLHENRDRSDAVFNA

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Crispr_ID: NZ_CP017717_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_7

2624675-2624779

Orphan

Consensus_repeat	Method
GGGCGCGCCCGCCGCTGGCCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_7

>merge|NZ_CP017717|7|2624675-2624779|CRISPRCasFinder
GGCGGCGCCCGCCACCGCTCGTGCCCGGGGCGCGCCCGCCGCTGGCCGCGCCTGGTGCGGGCTGGCCGTTGTGTGTGCCTGGGCCGCGCCCGCCGCTGGCCGCGC

>NZ_CP017717|7|6|2624675-2624779|CRISPRCasFinder
GGCGGCGCCCGCCACCGCTCGTGC	CCGGGGCGCGCCCGCCGCTGGCCGCGCCTGGTGCGGGCTGGCCGTTGTGTGTGCCTG
GGCCGCGCCCGCCGCTGGCCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046661.1\|2633455_2634640_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380651
NZ_CP017717.1\|WP_080038183.1\|2615589_2616027_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046659.1\|2621694_2622597_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080038193.1\|2632855_2633278_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213183
NZ_CP017717.1\|WP_080038184.1\|2616115_2616907_-\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
NZ_CP017717.1\|WP_080038191.1\|2628317_2631122_+\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|271150
NZ_CP017717.1\|WP_080038186.1\|2619477_2620248_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP017717.1\|WP_080038192.1\|2631133_2632846_+\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|377643
NZ_CP017717.1\|WP_080038195.1\|2634917_2638385_+\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|377643
NZ_CP017717.1\|WP_080038190.1\|2624897_2625638_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP017717.1\|WP_080038196.1\|2638388_2639411_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380519
NZ_CP017717.1\|WP_080038185.1\|2616999_2617866_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP017717.1\|WP_080046662.1\|2639463_2640360_-\|sugar-ABC-transporter-permease-YjfF	unknown	unknown	gnl\|CDD\|183235
NZ_CP017717.1\|WP_080038189.1\|2623425_2624601_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	unknown	unknown	gnl\|CDD\|239432
NZ_CP017717.1\|WP_080038187.1\|2620367_2621645_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP017717.1\|WP_080038188.1\|2622596_2623424_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080046658.1\|2617868_2619161_-\|poly(3-hydroxybutyrate)-depolymerase	unknown	unknown	gnl\|CDD\|238092
NZ_CP017717.1\|WP_155126915.1\|2634678_2634888_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080038182.1\|2614216_2615440_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080046660.1\|2625952_2628280_+\|ricin-type-beta-trefoil-lectin-domain-protein	unknown	unknown	gnl\|CDD\|238092

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080046661.1\|2633455_2634640_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380651	cd19996, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate binding protein such as CUT2. Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type 1 periplasmic binding protein superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. Members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes; however their substrate specificity is not known in detail.	2.10287e-105
NZ_CP017717.1\|WP_080038191.1\|2628317_2631122_+\|carbohydrate-binding-protein	gnl\|CDD\|271150	cd04084, CBM6_xylanase-like, Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains. This family includes carbohydrate binding module 6 (CBM6) domains that are appended mainly to glycoside hydrolase (GH) family domains, including GH3, GH11, and GH43 domains. These CBM6s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. Examples of proteins having CMB6s belonging to this family are Microbispora bispora GghA, a 1,4-beta-D-glucan glucohydrolase (GH3); Clostridium thermocellum xylanase U (GH11), and Penicillium purpurogenum ABF3, a bifunctional alpha-L-arabinofuranosidase/xylobiohydrolase (GH43). GH3 comprises enzymes with activities including beta-glucosidase (hydrolyzes beta-galactosidase) and beta-xylosidase (hydrolyzes 1,4-beta-D-xylosidase). GH11 family comprises enzymes with xylanase (endo-1,4-beta-xylanase) activity which catalyze the hydrolysis of beta-1,4 bonds of xylan, the major component of hemicelluloses, to generate xylooligosaccharides and xylose. GH43 includes beta-xylosidases and beta-xylanases, using aryl-glycosides as substrates. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold.	9.53951e-38
NZ_CP017717.1\|WP_080046659.1\|2621694_2622597_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.57027e-63
NZ_CP017717.1\|WP_080038184.1\|2616115_2616907_-\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	1.31222e-34
NZ_CP017717.1\|WP_080038192.1\|2631133_2632846_+\|DUF1080-domain-containing-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	1.69091e-110
NZ_CP017717.1\|WP_080038186.1\|2619477_2620248_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	5.51132e-52
NZ_CP017717.1\|WP_080038193.1\|2632855_2633278_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213183	cd03216, ABC_Carb_Monos_I, First domain of the ATP-binding cassette component of monosaccharide transport system. This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.	1.11123e-26
NZ_CP017717.1\|WP_080038195.1\|2634917_2638385_+\|carbohydrate-binding-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	7.87475e-76
NZ_CP017717.1\|WP_080038190.1\|2624897_2625638_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.28979e-47
NZ_CP017717.1\|WP_080038196.1\|2638388_2639411_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|380519	cd06296, PBP1_CatR-like, ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	2.49129e-105
NZ_CP017717.1\|WP_080038185.1\|2616999_2617866_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.88188e-24
NZ_CP017717.1\|WP_080046662.1\|2639463_2640360_-\|sugar-ABC-transporter-permease-YjfF	gnl\|CDD\|183235	PRK11618, PRK11618, inner membrane ABC transporter permease protein YjfF; Provisional.	9.80344e-130
NZ_CP017717.1\|WP_080038189.1\|2623425_2624601_+\|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	gnl\|CDD\|239432	cd03316, MR_like, Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).	2.33042e-79
NZ_CP017717.1\|WP_080038187.1\|2620367_2621645_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.19592e-46
NZ_CP017717.1\|WP_080038188.1\|2622596_2623424_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.69184e-70
NZ_CP017717.1\|WP_080046658.1\|2617868_2619161_-\|poly(3-hydroxybutyrate)-depolymerase	gnl\|CDD\|238092	cd00161, RICIN, Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ligand binding occurs on exposed surfaces of the compact domain sturcture.	7.70545e-32
NZ_CP017717.1\|WP_080038182.1\|2614216_2615440_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.02472e-47
NZ_CP017717.1\|WP_080046660.1\|2625952_2628280_+\|ricin-type-beta-trefoil-lectin-domain-protein	gnl\|CDD\|238092	cd00161, RICIN, Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ligand binding occurs on exposed surfaces of the compact domain sturcture.	8.18298e-30

>NZ_CP017717.1|WP_080038189.1|2623425_2624601_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein
MRITGYRTMTTVQEWGRPVGDVNGVFADGAVPVPLVLVDTDEGITGVGLGPHVEIEAVFAAIEGEDPRSVTALYDRMLRRTFKAGHAGAVFGTIGALDTALWDIKAQAAGEPLWRLLGGRDRQVPAYASGLDIGLTDDELVAVHQEYARHGLRAAKLKGGLDIERDRHRLTLVRDVLTEAGHGARPGLMLDVNEAWTRKQAVRHVCELERALDLTWIEEPVRRWDAEGLAAVGRGIRASVATGENLTGLEQFRPLLAAGAVDIVQTAVVWGVSHFLRVAALAHAHDLPVSPIGATPVPLLHAATSVPNHLASELQDLHPPRGLSLDLHIEDGAFILGDSPGLGITIDERTIDTSARHPATRAAEGPHIRPEHAGRRLLAVTGNSCPARRPG
>NZ_CP017717.1|WP_080038188.1|2622596_2623424_+|carbohydrate-ABC-transporter-permease
MPGTRLARWAAAVPMAALALATIYPLVFTANVAMKTRRDYVLDRFSPAASPRWDNLAEAWAGAGMARYFVNSFVVVACAVALLLLLGSMAGFALARLRFRGSSVIFLGCLAGLFVPFQVIMVPLTRVMADTGLVDTYPGLILAYVAQFLPFTVFLMTSHYRTIPAEIVDAARIDGNTVYGVYRRIMLPLGAPALLSVGILDALFCWNDVLIALLMMPSPEHRTLMIGVNALRGQYSDDIPTFASGILIAAVPVLMIYLFLQRQIADGVTAGSTKG
>NZ_CP017717.1|WP_080046659.1|2621694_2622597_+|sugar-ABC-transporter-permease
MARRQGGSHRDARKVRAERLAPYVLVAPAVLIIVALRLWPLALGVNFSFTGDGDLNGTPVGLGNYLELAADPLFRVSLRNVGLLVLLLPVAVAIPGLLATFIYLRVPGHRVYRSVYFFPAVLSPVIVGAIFNLLLGYDGPLNSLLAAFGAGPVDWLGDPGIAMFTVTGVHIWATFGMALVVFLAGFSTLDATLLDAARVDGASLARTIWHVIIPSLTRTIQFVFVTTMIGMLTSMFGLLFVMTSGGPEGSTYLPEYYIWHQQGQMNRPALASAASTVLFVVMLVVGLLQITLLRRTGRQD
>NZ_CP017717.1|WP_080038187.1|2620367_2621645_+|extracellular-solute-binding-protein
MKQRALWSALIAAALAVAGCGSATRTDTPSGDPQQKQRKLVVWDWKSGEPAAATYIEQAKADFAKRHPEVTVEFVAQPFDQYYTLLGTAIQAGKGPDVMLFNGGGQIRDRAGALLPLDEYVAGDKSRLAGWEAFSKDGKVYAAPVTLQGHPIYYNKALYEKAGLDPAAPPKTWDELVTGCAAIKKATGAACFALGNKEGFGIQFFLSGLGSGILTPREYDDWIAGKRDWDSPNVRRVFELWKQTGDKGLNNDGANSTAMFSDVFTVFETGKAAHIIGLMSDVGHWNDFAEFLPPDKIGVMTAPVVTEGATPSLPYDGGIGYAVAKWTKDPALAADLVRSLTSTGALTAFYQKAGAIASDTTIDVTQAGPAVAAIASEIKTGRPALHVALSSKTLDLMGRLSQQLLSGSTTVDKAVEQLAASDRKG
>NZ_CP017717.1|WP_080038186.1|2619477_2620248_-|FadR-family-transcriptional-regulator
MTASQETSGGVPAPPAWVRRPASLARAVTAELVERIVRGVYPPGTVLPPEPALCEAFSVSRTVVREAVKILQEKGLVQVRQGSGTMVTPPATWDLLDELVLTATIAEDESLAILDDLVVTRRVLESDMANVAARLAGPDTVDRLRELVDRMDELVDDPATYAESDRAFHDTIMRASGNRIARAVVRSLEGQVVNTARYLGRTERALCVASNLGHRRIYERIAAHDPGGAAEAMFQHITEAWIVRRSGTADPVRLRR
>NZ_CP017717.1|WP_080046658.1|2617868_2619161_-|poly(3-hydroxybutyrate)-depolymerase
MSRLRLFLTAVFSAVLLIVPAAAQTAMAQTAMAGPTAGCGKTPTLRSGSQSITTSGKNRSFILRIPDNYSNTTPYRLIFGFHWNGGTAGDVDSGGTSGYPWSYYGLRALSNNTAIFVAPQGLGNGWANSGGEDITFVDDMIRRIEADLCVDTTQRFAMGFSYGGGMSYALACARASVFRAVAVYSGAQLSGCSGGTEPVAYIGLHGLRDPVLNISAGRSLRDRFVRNNGCTAQNPPEPAQGSLTHVVTYYSGCRSGYPVAWAAFDAGHTPNPVDGRPGDYEPGENSWTRPVVWDFFTRLGGGDPNPPATGTIKGVGSGRCLDVPSTSQVQIWDCNGQANQQWASTSAGELKTSDGRCLDVNAAGTADGTAVITWTCNGQNNQKWRLNSDGSITAVGANKCLDVSGAGTANGTKVQIWTCHGGTNQKWTRA
>NZ_CP017717.1|WP_080038185.1|2616999_2617866_+|AraC-family-transcriptional-regulator
MPRTLHEHALFTGAPVLAGVHRLDLDVEPHAHDFLEIAVIGAGRGRHVTSQGERPLRRGQVVVLRPGAWHGFRGCEGLVVANCCLSAQALRAELAALHELPLLRRLLWTDPVASGTHGVAVTAVDPAAAGEAVTEIGLLERDLAADRRRPGRVLGRLVSVLGVLADGRAPEPETPGPAVHPAVAATVARLEAAPDRAWRLDDLARAVNLDPAYLGRLFKRHAGVTPLDFLARLRAERAATLLAHSALPAARVGAAVGWDDPTYFARRFRALVGLTPTEYRRRSRSETR
>NZ_CP017717.1|WP_080038184.1|2616115_2616907_-|phytanoyl-CoA-dioxygenase-family-protein
MATNTTEHAPSDVRADGTVPQELVTAYREHGFVRVRGVLTPGQAERFRAAAEAFLEAHRAESLERGGVFSQLVNVWQRDPALRELTLDRRLGRIAEQLAGFPLRLWHDQLLVKEPHNNAATEFHQDRPYWPHTGDRLPLSAWIALVDVPPERGCMTFLPGTQDRTGLRPQDLHHEDDLFEVDPSLRWAPRVTVPLRAGDCTFHSGYTGHMALPNRTGQARLAHVTIYMDEATRYSGAGHVVTDPLGLAAGERLDGDTFPRPWA
>NZ_CP017717.1|WP_080038183.1|2615589_2616027_-|hypothetical-protein
MVTPAHRSLLRLAAAALVAAATLAALPAAPALAANASQAQRLEKFLQRPEALRLWFTYSCDAGSDIRFVHGALRKDGENVAGAGRYRLNCDGKTHQRLLIFAPRNDVVRTGDSVEVTLRLGKAVDGRPEWVTEDTRTLTVTEVAV
>NZ_CP017717.1|WP_080038182.1|2614216_2615440_-|sensor-histidine-kinase
MRAKVLSSVGRLAVTNPFLTDLLFGLVVAGVTLVFGRVLGDDPAGAGYALRPLDPAGVALTLVANLALAWRRRVPVTVLMISSAASVVFHAAGHDARLNGVAPLLALYTVASLRAPAVSVPCALPPALSLWHAAFLAPAPFVWPNVAQTSIMTAVAWTFGNSTRMLTERNDRLARLTERLRQEQEDKARRAVTEERMRIARELHDVVAHHMSVIVIQAGLARYVLGSDPATARGALATIAGTGSEALGEMRRLLSILRIDTEDEGYDPAPGLERLDQLVERMRSAGLPVEVSVTGSVRPLPPGIDLCAYRVVQECLTNVLRHAGPATARVRLHYGGELELRVTDDGRGAAAAVREEGHGLIVMRERVKLYRGTVTAGPKPSGGFEVVVTLPLSPVSPTPPTDGEPES
>NZ_CP017717.1|WP_080038190.1|2624897_2625638_-|FadR-family-transcriptional-regulator
MTDTPRESGYRPGYEVAAEQVLELIVRLGLRPGDRMPTENELAQQLGTSRTVVREAVKILSALGRVRAQKGRGLYVADDEGMFGTGRWGSFFLPTDLDHVYMLFEFRRAQEMETSRLAARRATPAELRAIEEAAGVCRHGFETGREELFNEGDDAFHTAIATASHNMFLQVAVREARRLQAQSSLIGLRGSVGGHAAKAVEEHDAIYQAIRAGDPEAAAQSAATHIDNTLDDYRREIQQRLFFSSH
>NZ_CP017717.1|WP_080046660.1|2625952_2628280_+|ricin-type-beta-trefoil-lectin-domain-protein
MIGIVTAALSAAFALVAPATSASAATTTLYAAPAGTGTACTSAQPCALPAAQAAVRSLNAGMSGDIVVELAGGVYRLSQPLRLTAADSGTNGYTVRWQAAAGATPVISGARAVTGWSLADSGKNIWRASVGAGIDSRQLYVDGALATRARTAVNRSDFTASSTGMRFTSGALSYLNNLANQGRIEMESVGSFTDRYSPVQSIAGNLITMKQPAWNNNNFGYDTFTSPHRAGPLYLVNAYEFLDSPGEWYLDPGTGTLSYIPLAGQSMGNVSVELPVLQSLVQVGGTYDAPAHHLTFSGITFTGTSWLGPSSDQGYVDQQTGAYMAGNWSWPAFTSCHEGCRQFEATRPNWFQMPAAVQVSAANTITFTDSRFVNLGQTAIGIGNDANAHASGVGLGASGITVTRSEIARSSAGGVVVGGVRADAHHPSDARMVNRDITVSDNRIHDLGLDHRGIVSVLTTYVTGTDVSHNEVYNLPYTGMSIGYGWGSNEPGGSTHYANRGLYDFQPRYTTATTASGNKLVGNYVHDVMQQMTDGGCIYTLSWNPGAVISDNHCLRTNGWFGVYFDEGSRYYTVRNNVLANTGTWATANYWGGENMGNFTVTGNWSTNGSTNVTNGDRGNVVNNNVTVANGAWPSGAQAVIAAAGPRSGPSGNTGPIKGVGSGRCLDVPSTSQVQIWDCNGQANQQWASTSAGELKTSDGRCLDVNAAGTADGTAVITWTCNGQNNQKWRLNSDGSITAVGANKCLDVSGAGTANGTKVQIWTCHGGTNQKWTRA
>NZ_CP017717.1|WP_080038191.1|2628317_2631122_+|carbohydrate-binding-protein
MPRRLRLALIAAMLATTALHASPANAVDIPPSDYQQVSLASGGAELGEAMSLAVLPNRSVVHTARDGTVRITDAAGTTKVAGKLNVYTHDEEGLQGVAADPGFASNRYLWLYYSPRLSTPTGDAPSTGTQSQFDQWKGELYLSRFTLKSDDTLDLSSEKVVLRVQNDRGQCCHVGGDIDFDAAGNLYLTTGDDTNPFESSGYAPLDERTNRNPQYDAQRSAANTNDLRGKLLRIKPQPDGSYTIPSGNMFPPGTAKTRPEIYAMGFRNPFRMSVDKATGVVYLGDYGPDAGVTSSTRGPSGQVEFDRVTGPGNYGWPYCTGTNTTSETYNEWNFATNSTGPKYDCAGGPTNNSFRNTGLTTLPSAKPAWIRYAGDAGSPPEFGSGSESPMGGPVYRFDPALSSSVKFPQSLDGRFFAGEYGRRWIKAIEVRQDGGYGEIAAFPWSGTQVMDMAFGPDGALYVLDYGTGSNNQALYRIEYIGSANRNPIAKASADRTSGPAPLTVSFSSAGSSDPEGGALTYAWSFGDGTTSTAANPSKTYTANGTYTATLTVRDPQGLTGTASVIVTVGNTAPSVTLTAPTDGQLFSFGDTVPFQVTVTDPEDGTVDCDRVTVAYLLGHDSHRHQITSKTGCSGSIAVPVDGEHDAAANIYGVFEASYTDQGGLTSTSARVLQPRHRQAEHFGAQQGVQTADHTTAEGGKTAGFVDDGDWISFQPYGLASATRFTARVSSGGAGGRIEVRAGSPTGTLLGTATVASTGGWDTFADVSAALSGAPAGTTTLYLVFRGPTGQGYLFDVDAFTFDTGTPSSSTSALKGVGSGRCLDVNGASQANGALAQIWDCNGQANQQWTSTSAGELRVYGSKCLDVNGAGTADGTAVIIWDCNGQNNQKWRLNSDGTITAVGANKCLDVGATANGTKARIWTCTAGTGQRWTRV
>NZ_CP017717.1|WP_080038192.1|2631133_2632846_+|DUF1080-domain-containing-protein
MLRPPTPTALRRLAATVAALIAAAILIPAVPAQAAAFKVLVFSKTAGFRHDSIPAGIQAIRDLGATGDFTVDATEDGNAFTAANLAQYRAVVFLSTTGDVLNDTQQAAFQAYVDGGGGYVGVHAAADTEYNWPYYGQLMGAWFNNHPAIQQATVRTEDRAHAATAHLGATWSRTDEWYNYRTNPRPNVRVLQSLDEGSYSGGGMGDHPITWCHPQSSGRSFYTGLGHTQESYADPSFRALLLGGIRYAAKAVNADCRPETGYTALYNGSTTGWSQAGPGSFANSDATLTSQGGMGMLWYSAKELRSYSLKLDWRMTGDSNSGVIVGFPATSDPQAALDTGYEVQIDATDTTDKTTGAIYGVKAADIAARDAALNPPGQWNTFELLVEGERLQVFLNGTKINDFTNTDPARSLQQGYLGLQNHGSGDVVSFRNVRVKELTSTPGGGTGPLKGAGSGRCLDVSGASQANGALAQIWDCNGQANQQWTSTSASELRVYGSKCLDVNGAGTADGTAVIIWSCNGQNNQKWRLNADGTITAVGANKCLDVGGTANGTKARIWTCTASAGQRWTRG
>NZ_CP017717.1|WP_080038193.1|2632855_2633278_+|ATP-binding-cassette-domain-containing-protein
MLSMRGIGKSFPGVPVLSGVDLEATAGEVHAVVGENGAGRSTLMKIMCGVHRPDEGRRERVPRPRHRPARRPRGRRQGARRSRRPVRTGPPPLGAPGAGGPLPVRRQRAEGRARHAADDGATAGRARRGSGHAPGSRRDG
>NZ_CP017717.1|WP_080046661.1|2633455_2634640_+|ABC-transporter-substrate-binding-protein
MPRREAAAAAVIAALVVAGCTTDRPEPTTAASTQGSGTGAQSKFFVQADFDAQLAMRSQTPEGPANKPWEQAIAPKMIDTATYKKDGPYHLCFSNAAVNNPWRQVGWKTMQAEVGLHKEITKFTALDAEGKDDKQISDIAELQAKGCDALIVSPNTTATLTPAVTAACEKVPVIVFDRGVQTDCPVTFIKPIGGYAFGADAAEFLVEKVPAGGKVLALRILPGVDVLETRWSAAKVVFDKSKVQVVGVEFSDGDAAKTKSIVSDYLQRYGKIDGVWMDAGATAVAAIEAFEDAGLPVPPINGEDQQDFLQKWKDAGLTAVAPTYPTYQWRTPVIAALKILKGEQVPQTWNLPQPKVTGENLATYLKPNMPPLHYALCGCEDLPGFPEAWGGTKG
>NZ_CP017717.1|WP_155126915.1|2634678_2634888_+|hypothetical-protein
MFSIGVNTWVWVSPLTDDCHLALDTYHLNIEEKDPAQAARAAAGASIGRPLAASQDAPATDGRTYLRTL
>NZ_CP017717.1|WP_080038195.1|2634917_2638385_+|carbohydrate-binding-protein
MRRSRLFPALAAALLGLLMSVSPQVAHAAAPAFKVLLFSETASGAYRHDSIAAGVTMFQQLAADNNFQLDRSEDSSVFTSAAMSTYDAVIMFQTSGMVWDNDAQRQAFQSYVRSGRGVVAVHNATDMNIESQFPWWDQVVLAGAHMTAHSSILQGTAKVADKVHPSTKGLPDRWVRTEEWYNFDKNMRGSVHVLVTADETTYDAGPNKMGADHPISWCHNPEGARVWATAMGHNASSYSEPLFKQHLLGAVQWAAGAAAGDCGGTVTSRFQKVTLDGAPDQPMELDVAADGRVFYISRSGKVNLIPAAGGGTRVIGTLSVYDGGEDGGIGLALDPNFATNGWIYLNYSPANGGEVNRVSRFTFNGTSLDLSSEKKIIEVPAYRNVDEPGHTGGYLAFGPGGNLYIGPGDDTNPNGSSGYAPIDERQGREHYDAQRSSANTNDLRGKILRIHPEADGTYTIPSGNMFAPGTAKTRPEIYAMGFRNPFRFSVDKTTGWISVGDYGPDAGSANANRGPEGTVEWNLIKQPGFYGWPYCTGNNIPFNDFNFATNTSGAKFNCSAPVNNSPNNTGLTNLPAAQPATVWYNYHASAEFPEINCCGGAAPMGGPFYRYDAAGASDRRFPEYFDGAAFFYEWSRNFVKEFRLDSSGGLLKINPFVAQLAPRAPIDMKFGPDGALYMADWGNGFGHANTDDSIYRIDYVAGNRAPLAKASASPDSGAAPLTVAFSSAGSADPDGDAITYAWDFGDGATSTSANPSHTYTANGTYQAKLTVRDSGGKTGSVTVPIVVGNTRPKVTFSAPPDGGFIDFGDDVDYTVGVTDAEDGAADCTKVNVVTALGHDQHAHDTGQYTGCSGTVTTTASGHDEFSNVYYVLSADYTDRGGLKGTAGITLQPKHKQAEHFTGSSGIRVVEEAGAEGGRRVGDISNNDWISFSPISLSGIDTVSFRVSAPSSTGASIELRADSPTGALLASASVPATGGWNSYVSLPVVPVTDPGGTHNVHVVFKAPSANAFDVDAITFNGDGVGQGDGTPPGDTSVIKGVGSGRCLDASNTTQAQIWDCNGQASQQWTATAASELRTAAGRCLDVNGAGTADGTAVLVWDCNGQNNQKWRLNSDGTITAVGANKCLDVNGAGTANGTKVQIWTCNGGANQRWTRS
>NZ_CP017717.1|WP_080038196.1|2638388_2639411_-|LacI-family-transcriptional-regulator
MATESSPLTIAQLAELAGVSTATVSKVVNGRAEVSSETRAAVEELIRLHGYRRQRRRSTPTALVELVFHALEGDYPVEITKGVAQVAHEHDLTVGISDLRRDRSAADAWLDVVLRRRPSGVIAVFEGLTEAQREQLARSEIPLVLLDPADVPARDLPSVGAGNWNGGLIATRHLLELGHRRIGIVTGPDSAVSSRARLDGYRTALDMAGVPADPELIGRGDFFIEGGLAQAERLLRLPDRPTAIFAANDGQAIGVYHAAHRLGLRVPDDLSVVGFDDMPSARWHLPPLTTVRQPLTEMAAAATRMLLQLANGERLARNRVELATELVVRESTAPPPTPAG
>NZ_CP017717.1|WP_080046662.1|2639463_2640360_-|sugar-ABC-transporter-permease-YjfF
MFVAGGVRYEGFATGQIVLNVFIDNGFLLVVAVGLTFVILTGGIDLSVGAVVALSTMVSASLLQAGWPWWAVIALVLAMGVVLGGGMGAIIHFFGIQPFIVTLAGMFLARGLCYTIGTDSIPITDPAFTAFAQTRIDLFADLWISPSVLIAVAVVLVAAYVLHYTRFGRAVYATGGSEQSALLMGLPVARTKITVYTVSGLCSALGGVLLAFYMLSGYGLHAVGMELDAIAAVVIGGTLLTGGSGYLLGTVLGVLVLGLIQTVISFEGTLSSWWTKIFIGALLLVFILLQRLMSRRGA

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Crispr_ID: NZ_CP017717_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_8

2783538-2783667

Orphan

Consensus_repeat	Method
GCGTCCACCACCCGCGCCGACC-----GCCCGCCAC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017717_8

>merge|NZ_CP017717|8|2783538-2783667|PILER-CR
CACCCGCGCCGACCGCCCGCCACTTGCGCTGGACATCCGCTGCGTCCGCCGCTCGCGCCGATCGCCCGCCATGTTCACCGCTCGCGCTGACCACCCCCGGCGTCCACTACCCGCGCCGACCGCCCGCCAC

>NZ_CP017717|8|1|2783538-2783667|PILER-CR
CACCCGCGCCGACCGCCCGCCACTTGCGCTG	GACATCCGCTGCGTCCGC
CGCTCGCGCCGATCGCCCGCCATGTTCACCG	CTCGCGCTGACCACCCCCGGCGTCCAC
TACCCGCGCCGACCGCCCGCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080038312.1\|2780040_2780853_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017717.1\|WP_080038323.1\|2793980_2794535_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_155126969.1\|2784363_2785791_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080038310.1\|2778325_2779297_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293803
NZ_CP017717.1\|WP_080038321.1\|2788802_2789555_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080038322.1\|2792672_2793902_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NZ_CP017717.1\|WP_080038308.1\|2776071_2776839_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NZ_CP017717.1\|WP_080046684.1\|2790226_2791621_-\|vanadium-dependent-haloperoxidase	unknown	unknown	gnl\|CDD\|239492
NZ_CP017717.1\|WP_080038324.1\|2794622_2795633_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|225070
NZ_CP017717.1\|WP_080038320.1\|2787420_2788806_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP017717.1\|WP_080038319.1\|2785957_2787424_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP017717.1\|WP_080038325.1\|2795635_2796178_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|235811
NZ_CP017717.1\|WP_080038317.1\|2783728_2784367_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_080038309.1\|2776965_2778315_+\|carotenoid-oxygenase-family-protein	unknown	unknown	gnl\|CDD\|376981
NZ_CP017717.1\|WP_080038311.1\|2779240_2780014_+\|DUF3307-domain-containing-protein	unknown	unknown	gnl\|CDD\|371703
NZ_CP017717.1\|WP_080038307.1\|2775274_2776078_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017717.1\|WP_080038316.1\|2782634_2783087_+\|globin	unknown	unknown	gnl\|CDD\|381284
NZ_CP017717.1\|WP_080038313.1\|2780852_2781314_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NZ_CP017717.1\|WP_080038306.1\|2774573_2775278_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP017717.1\|WP_080038315.1\|2781947_2782487_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080038312.1\|2780040_2780853_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.93501e-26
NZ_CP017717.1\|WP_080038323.1\|2793980_2794535_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.15618e-09
NZ_CP017717.1\|WP_155126969.1\|2784363_2785791_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.29849e-31
NZ_CP017717.1\|WP_080038310.1\|2778325_2779297_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293803	cd07717, RNaseZ_ZiPD-like_MBL-fold, Ribonuclease Z, E. coli 3' tRNA-processing endonuclease ZiPD and related proteins; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Escherichia coli zinc phosphodiesterase (ZiPD, also known as ecoZ, tRNase Z, or RNase BN) is a 3' tRNA-processing endonuclease, encoded by the elaC gene. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme; this subgroup includes the short form (ELAC1). Only the short form exists in bacteria. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	6.5806e-11
NZ_CP017717.1\|WP_080038322.1\|2792672_2793902_-\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.55927e-121
NZ_CP017717.1\|WP_080038308.1\|2776071_2776839_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.14927e-21
NZ_CP017717.1\|WP_080046684.1\|2790226_2791621_-\|vanadium-dependent-haloperoxidase	gnl\|CDD\|239492	cd03398, PAP2_haloperoxidase, PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.	2.36417e-47
NZ_CP017717.1\|WP_080038324.1\|2794622_2795633_+\|amidohydrolase-family-protein	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	1.75493e-33
NZ_CP017717.1\|WP_080038320.1\|2787420_2788806_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.25524e-89
NZ_CP017717.1\|WP_080038319.1\|2785957_2787424_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	3.37907e-11
NZ_CP017717.1\|WP_080038325.1\|2795635_2796178_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|235811	PRK06474, PRK06474, hypothetical protein; Provisional.	1.57507e-21
NZ_CP017717.1\|WP_080038317.1\|2783728_2784367_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.98792e-68
NZ_CP017717.1\|WP_080038309.1\|2776965_2778315_+\|carotenoid-oxygenase-family-protein	gnl\|CDD\|376981	pfam03055, RPE65, Retinal pigment epithelial membrane protein. This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.	1.49666e-124
NZ_CP017717.1\|WP_080038311.1\|2779240_2780014_+\|DUF3307-domain-containing-protein	gnl\|CDD\|371703	pfam11750, DUF3307, Protein of unknown function (DUF3307). This family of bacterial proteins has no known function.	1.48713e-07
NZ_CP017717.1\|WP_080038307.1\|2775274_2776078_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.78934e-16
NZ_CP017717.1\|WP_080038316.1\|2782634_2783087_+\|globin	gnl\|CDD\|381284	cd14775, TrHb2_O-like, Truncated hemoglobins, group 2 (O); uncharacterized subgroup. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P).	4.55509e-40
NZ_CP017717.1\|WP_080038313.1\|2780852_2781314_+\|transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	1.9706e-15
NZ_CP017717.1\|WP_080038306.1\|2774573_2775278_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.7274e-10
NZ_CP017717.1\|WP_080038315.1\|2781947_2782487_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.6599e-22

>NZ_CP017717.1|WP_080038316.1|2782634_2783087_+|globin
MTSLYDHAGGTEALHRLEEIFYTKLLTDPLLKQLFPERKPSHVPNLTSFTSESFGGPDAFTRGPGFAYLISAHRHLHITEEQRQRFVELYMEAFEEAGLPRDQEFLDAVREHVEFGSQVAMQNSHATTDADLHPLREVPRWTWAGDNPTP
>NZ_CP017717.1|WP_080038315.1|2781947_2782487_+|GNAT-family-N-acetyltransferase
MLDESRHAHDLLTGRLSLRRPSPDDIDAIHAIHSDPATCLHNPSDALSKREEATELFHRWDDHWQRFGYGYWTVRRQGSDRPLGFCGTKTMDLNGMSVLNLFYRFETSSWGQGLATEAATAVVDWVTQRAPELPVIARVRPANTASQRVAIRAGLVRAAHLDLPGEDGLGWIYAKNLHH
>NZ_CP017717.1|WP_080038313.1|2780852_2781314_+|transcriptional-regulator
MDAGKRNTFIVSVGDLLASWNLPHATGRVYGLLLVSETPQSLDAIAAELALSKASVSTAVRQLDSWGLARTIPQPGSRRLLVEAAGGIASLLEASHARARTLIAALREGEDLVSPGPARRRLQDVIGLFSGYVDVGSELLSAYRRQQERREDD
>NZ_CP017717.1|WP_080038312.1|2780040_2780853_+|alpha/beta-hydrolase
MLNLVNKLPLDGCDLRYADSGGAGTPVVFTHGAGVDHAMFDAQAGHLRARGFRVIVWDQRGHGLSRPAGTPFTAERALADLSALIAHLALDRPVLAGHSLGGNLGQALVRRNPHLARALIVIGSTWNTGPLSWSERLLLKLAAPALLALPAGRLPELMADASALTPAARADARRAFSQLPKRDFVQVWKATVELVAPDPGHRTPVPLCLIRGDHDRTGNIAAAMPRWARAEGVEEVVIPDAGHLCTQDNPQAVNTAIDTFLHTLTAREER
>NZ_CP017717.1|WP_080038311.1|2779240_2780014_+|DUF3307-domain-containing-protein
MPALQQFRVVGPGFLRVRHPKAPFPSGRGRRFPPPSRSSVRDRSAPISGEHTDFPGRSGHDGRPLRGVFDCSKPRGEGATVTSASAAAITAVTFAALYAGHQIGDHVVQSNSTAVAKGVPDAEQLARGVSPWTGWRACLRHVAGYIGTQAAALALVCVAVPMQLAGMVTALLVSAGTHAVIDRRWIVRRLIELKKCHDWAEGPYLIDQSLHVGAMLVAAVLAVVVDDFGGVAAVAIGALALVGAALLIERRSATAQV
>NZ_CP017717.1|WP_080038310.1|2778325_2779297_-|MBL-fold-metallo-hydrolase
MTHAQEPWPDHPELLERGHPFRQWKTWRIPGTDLTLTGYSRANDKTFFHIPELRCCLDAGLCEGRQVDTVFLTHTHHDHAKDLDFLASKASGVDIYLPAASVPYAEAYLRASAELNHGADFDATLAGGHRLHGVKQDDEIVFGRRGHHVRVVECEHKVPCMGYAFSERRKALRPEFEEMWRSMTAEGRDAEFGRFVALQRKKGVEVDAEVSRPLFAYLGDTHVSVFERSPWLFDYPVVITECTFLDDAELERANRVGHTVWSRLKPVVEAHPRTLFVLVHFSLRYSDQEVLDFFRGAGARPGNVVVWAHPASRLPEQHQRSHP
>NZ_CP017717.1|WP_080038309.1|2776965_2778315_+|carotenoid-oxygenase-family-protein
MSETVPLHLAGNNAPVPDEVTLEPSGVVGEIPAELRGQFFRNGPNPRTGWSPHSFAGDGMIHTIALDGGRARWYRNRYVRTPLYEHPGTSRFALAFDQDSGRIDYRVTTANTHLIAHAGRLFALEEGGFPYEVTPDLATIGPHTFDGALRTPMTAHPKTCPITGELLFFGYQLRPPYLTYYRASAAGEIVQTRVVDVPRATMMHDFAVTRHHVIFMDLPVVFDRAQAAAGGPPWRWDDAHRARFGVLARTAGADAPVRWFDVAPCYVWHTMNAFEGPGGDTITVTGTRVPTLWRDGAGDLEGGLPVAYRWTLDLRSGAVAEEPLDDAPSEYPRVAGPALGLPHRYGYTTSFSLDAEPDRSEIYAYDLVGGGRAVHRLPPGRTCGEAVFVPKSGSAGENDGYLMTFVHDRRTGTSHLAILDAADLAAPPLAEVHVPVRIPAGFHGNWIPS
>NZ_CP017717.1|WP_080038308.1|2776071_2776839_+|MerR-family-transcriptional-regulator
MLTIGELAAYTGVTVRTVRHYHAKGLLPEPERDHSGYRRYDATAVVELIRIRTLAEAGVPLARVGELLRAGEEEFAAAVADIDRRLEAEIRERQRHRKRIARLASGDRLALPAEVVEHLERLRALGVDERIVRAERDGWIPLALHAPERVPEWTARKREQLGDPTLVGFYRTLSQALDRADDDPRLVELADRLAAYLTRMAAERGDDYVEDTGIDATLAQLMDTLAFDTVPPARRLIELLRQRGWTGWTRLERIR
>NZ_CP017717.1|WP_080038307.1|2775274_2776078_+|alpha/beta-hydrolase
MTTGTTGGSTVQTFTIQHDGVTIPVSRGGRGRPLVLCPGLSSTQADLREPVELLRRDHDVVTFDLRGHGLASAAGRYSFQAFLSDLTAVLTELERRGLPEPPLLVGYSLGADLAVHYAGEHPGAVAGLVLIDGANPVPEPFLTEDVLPAFRALWEEAATRQRAARQVLLTGQEILDLNLEIDAVRAKILDRYAAIDRPIAMIMSTAMAGDEERFNRNWRAGVERLVREHPRVTTTWLDADHRLIVTHADDIARIIRHLSASWRLDRC
>NZ_CP017717.1|WP_080038306.1|2774573_2775278_+|TetR/AcrR-family-transcriptional-regulator
MARERYHHGDLRGALLDAAETLVRERGTDGWSLREASARVGVSPSAAYHHFASRDMLVRALSERVLAWLGERLRHDCEHAPGQEDDPQRRLIALGRSYVTWALDDPAVARLVLRGGATGPDSAITPHPHDVLTAELDRLTAAGALPEPAREGAEFVVWAALHGLAVLLADGLVRFDDPHAVTLQTERVVRTTLNGLAQEASHAAGRPAGRSAHTERLARVDLTLTQRQPPSMGA
>NZ_CP017717.1|WP_080038317.1|2783728_2784367_-|response-regulator-transcription-factor
MIRVLIADDQALLRGSFRLLIDSEDDLTVVGEAADGQEAVALARAESPNVVLMDVRMPRLDGIGATQQLAGDTRILILTTFDLDEYVYAALRAGASGFLLKDAPPDDLLKAIRVVASGETLLAPSVTTRLIAEFVRRPAQQVFHGLDTLTDREREVLTLIAHGLSNAELSDQLQVSPGTVKTHISRLLTKLQARDRAQLVIAAYEARLVTPR
>NZ_CP017717.1|WP_155126969.1|2784363_2785791_-|sensor-histidine-kinase
MHLLAQRPPPWLLILVDTVVAVLLALASTASPPELAADAGSMALCWLLAAPVAVRRAWPEPAYYSALLIGIAVLFVQVNRLLPAIVVALAIYPVATGRPVRRSAIALVTGLLVTGGAALLSALSAPQRANGWPDPVLIVGMVWLVIAASWSLGTAARTRREFAAREARQEARRQAEQAAADERLRIVRELHDVVAHSMSMITVKAGVAAKVLDKHPAEGRKALLAIEELGRGSLMEMRQLLGVLRAADGAPERAPLPGLADLPALVERAAEAGVRVDLSVSGTLPDSMGASVYRIVQEAITNVVRHAAPAHCRADVSVVGRTVRISVIDDGPGQRLLPDDSDESGQRFLLGRPGESVQRVLSDRPGESVQRVLSDRPGESVQRVLSDRPGESGQRLLSSSPNGSGQRILPDRFDGSGRRLPPDRSDGSGQRVLPGRSGGHGLVGMRERVMMYGGTFEAGPRPEGGFGVHASWEIS
>NZ_CP017717.1|WP_080038319.1|2785957_2787424_+|alpha/beta-fold-hydrolase
MNRRGLITLCLAACLAVPLGSVALASAQAHDLVWKDCGDGLRCADLVVPVDWADPGGPSTSVHVAKLPATGKSAKPLIVNFGGPGTSTTMLRRKGDPDAPAELPRLLDELQRSFDVIAIDPRGMSEPASGKRVSCAEPESSIYSLLLARTKQDWDAHAAKNAAHQASCRIMAKSTWGGMTAWNVAHDIDALRAALGQDKIIYAGNSYGTVYGQAYLELFPQRVGRMYFDGTADHTQPDFEAWLRNYAVTQERHLTLFRDWCARRTDCALHGRDAGRVWDELVARARRAPLPASSGRTVSEGQLYAGGIKGMNPARWPQLATALRKALDGDAGDFLEELRPDEGGTSISQDALCNDFMPKLPTYEEFQGIEARLREIAPRFGWIEGRFELGRCWGRSGGASWAPHPLRVKDTPPILFAIGELDNNTNHLGQAHVAEQIPSAQVLRHGDGHASWAGNTCLRRHVFTYLSTGALPAPGTRCPAERIQKVGK
>NZ_CP017717.1|WP_080038320.1|2787420_2788806_+|ATP-binding-cassette-domain-containing-protein
MIEVTDLTKVYGSTRAVSGLTFDVRPGQVTGFLGHNGAGKSTTMRMILGLHAPTSGKALINGVRKHDLRDPMREVGAMLDATEVQGGRTALDHLQALAYAGGISRRRVVRLLEEVGLAGVARKRIAGFSQGMRQRLGIAAALLGDPGVLILDEPANGLDPDGIRWLRTLLRSLAAEGRTVLLSSHLMTEMSLTADRLIIIGHGRLIEDTTTPELLARFQDEVLVRSPHASRLATVLEAAGATVRAAPPPGTPTAGTAVRAAPPALPGTAGTWRAAAPLDAHTADGGVHVAPSDLPAADAAHVAPPGRPEADGRRPVAPPGMPEADHTVGATPSGLPGADGNVRVAPQDTRGADSNVRVAPQGTHGTDSNVRVAPQATRGADSNVRVAPQGMHGTDGRVRVVPPGTLAAGEAVYEPGGEGGLLVAGMSAAAIGDAALRSGCSIHELTPQQVSLEEAFMELTR
>NZ_CP017717.1|WP_080038321.1|2788802_2789555_+|hypothetical-protein
MINVIASEWLKLRSLRSTYYVLACTLSALVITGAAALSISRYFDTRGLSGEIVGTGLRFSADIPPVLFGMLGVLAISGEYGTGMIRLTLTTVRRRWMALLAKATVVAAVAAVGGQVVAFATYLTAQAVVSGRPIGASLSEPAALAEVLAAGAGSAVAAVIGLALATILRSTPGALVALVALPLLPAVIERFLPAPWNDWVASLTLPALTRQLAGVPDAGGFGPFTATAILAGYVVFSLFAAALVINRRDV
>NZ_CP017717.1|WP_080046684.1|2790226_2791621_-|vanadium-dependent-haloperoxidase
MAALGSALALAVTGTVVALPQPAAAAAPNYDGDPTQYWNQVLVDVFRQLNGPDAAPGRLARAAAMMNAAIFDAETMYRDQWRTRLYQPYLQAGRYFSLGETDHEEERVIGRTAYNILLDLFGTATLHSPSMTNLLDQRFTHRFGTSPTDFDYLDLQVVSSVVQRMRQFRSDDHSADSTVYTPSPERGAWRPTGDPSCTTAQNAVTPNWGRVKPFSMTSGSQFRRPTPEQAITYDQLLQTTEYQRQVDLVRRFGGAADTAKTKLERTTSQTAAALFWANDVDDTYRPVGQLLVHTGQVARQLNVTSPYENARLYTLVSLALADAAIAAWDTKYETRIDLWRPESAIREIDPDWRPLSVDRNGNHFSPCFPSWVSGHATFAGAWAGIMTRFFDGNATFTVDTEDPSAPVKSKTFTSFAQAAQENAQSRLWLGVHYPWDADDGMAIGDAIANHVFTNELTELPTTPR
>NZ_CP017717.1|WP_080038322.1|2792672_2793902_-|MFS-transporter
MSKERSTTSKGRSGRALLVWGLLVVAANLRPSLTVVGPLLDRVQADLGLAPAVAGLLSTLPLLAFAVMSPVVPRLAARWGPERLLWWALVVLAFGIGVRWVPSAIGLFAGTVLIGAGVAVGNVLLPSLIKRDFPTRVGLLTSAYATVMGAVAAVASGVAVPISQAAAGGWSTAFGCWIVLALAAVVLWLPQVRAPRPAAETIRRHRLPWRSALAWAVTAFMGLQSLGFYVAVTWLPQVFQDSGVSAATAGWLLFLFQAVAVLTSLAAPAALRRAGDQRTVATLSSAVVLGGYLGLLVAPGWAWLWSIVLGLGGGACLVLALAFLSLRAQDATVAGTLSAMAQSVGYLVAAAGPVIFGLLHTVSSGWHAPLVLMCVAAAGQVIFAMAASRGTVAPTDDQTLEPAPSPGRS
>NZ_CP017717.1|WP_080038323.1|2793980_2794535_+|TetR/AcrR-family-transcriptional-regulator
MSTPQRRKPRTDAERNRDRVLEAARLLFAESGHDVPMSEVARAAGVGIGTLYRKFPTREALIEAIAERRAGDLAAAGHTFAGEEGQGLAGFLFHVGEVLAGDRGMSEVIEKAMGSAEPQGETRDALLAVIAELLDQARAQGVAGQDVTAEDVNMIICGLAAVIRNAAGDWRRYVAVALEGLRPR
>NZ_CP017717.1|WP_080038324.1|2794622_2795633_+|amidohydrolase-family-protein
MRIIGVEETVIVPAVHEAYKRAGSPQIPARGFGDSPIARNLRETGERRLAHMDDQGIDVAVLSLASPGVQDLPEAEAIAVAREANDQLAEIVAARPDRFQAFAAIPTQSPAAAAAELERAVVELGFPGAMLYGRTGDRLADHRDNDELYATAERLGVPLHFHPQTPVQPVIDAYYSGIGPIGTPLAGAAIGWYYDLGVQYLRMIFSGVFDRFPGLQVIAGHWGEVVLFYLDHTGFFAEAGGLQRPLADYFKQNFWVAGSGTNSPRYLRWTAEVMGTDRMLYSTDYPFTYGFRPGGFPYVDTSNGAARSFLESAPFTDEQKADIAHRNWERLTARAS
>NZ_CP017717.1|WP_080038325.1|2795635_2796178_-|helix-turn-helix-domain-containing-protein
MDTLELLAHPVRLRIVHAMRGERELTTGELCARIPDTSKAMVYRHVDLLAAAGILEVAGERRVRGAVERRYRLRHDRAVLDAGVLAAMTPDDHRRAFATAMAVLVAEFNAYLEREEADPVADLIGYRQHAVWLSREELEEMITAFRRVILPLLANQPTPDRTQHLLSPIFFPVERPPAGS

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Crispr_ID: NZ_CP017717_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_9

4737633-4737717

Orphan

Consensus_repeat	Method
CGGTCATCGGCCGATCCCTTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_9

>merge|NZ_CP017717|9|4737633-4737717|CRISPRCasFinder
CGGTCATCGGCCGATCCCTTCGACGAGCCCGAGGAGGCCGGCGGGCAGGAGGCTGGTGGGGGCGGTCATCGGCTGATCCCTTCGA

>NZ_CP017717|9|7|4737633-4737717|CRISPRCasFinder
CGGTCATCGGCCGATCCCTTCGA	CGAGCCCGAGGAGGCCGGCGGGCAGGAGGCTGGTGGGGG
CGGTCATCGGCTGATCCCTTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046863.1\|4752283_4755403_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225669
NZ_CP017717.1\|WP_155127777.1\|4757403_4758579_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226651
NZ_CP017717.1\|WP_080039837.1\|4743245_4744175_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176131
NZ_CP017717.1\|WP_080039833.1\|4735998_4736652_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046859.1\|4718000_4718738_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366780
NZ_CP017717.1\|WP_080039831.1\|4732626_4734180_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP017717.1\|WP_080046860.1\|4731955_4732552_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP017717.1\|WP_155127766.1\|4722109_4726168_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235334
NZ_CP017717.1\|WP_080039830.1\|4728682_4731757_-\|glycosylase	unknown	unknown	gnl\|CDD\|369609
NZ_CP017717.1\|WP_155127771.1\|4747087_4748626_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|284851
NZ_CP017717.1\|WP_155127774.1\|4749968_4752287_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|274576
NZ_CP017717.1\|WP_080039826.1\|4719003_4720731_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200577
NZ_CP017717.1\|WP_080039839.1\|4745618_4747106_+\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NZ_CP017717.1\|WP_080039838.1\|4744286_4745606_+\|citrate-transporter	unknown	unknown	gnl\|CDD\|225407
NZ_CP017717.1\|WP_080039840.1\|4748884_4749913_+\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_CP017717.1\|WP_155127768.1\|4741877_4743182_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP017717.1\|WP_080039832.1\|4734307_4735930_+\|ATP-dependent-DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|223588
NZ_CP017717.1\|WP_080039841.1\|4756374_4757319_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP017717.1\|WP_080039829.1\|4726243_4728667_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|365866
NZ_CP017717.1\|WP_080039827.1\|4720772_4721942_-\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379079

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080046863.1\|4752283_4755403_-\|ABC-transporter-permease	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	2.4702e-06
NZ_CP017717.1\|WP_080039831.1\|4732626_4734180_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.75178e-60
NZ_CP017717.1\|WP_155127777.1\|4757403_4758579_-\|alpha/beta-hydrolase	gnl\|CDD\|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	4.05892e-10
NZ_CP017717.1\|WP_080039827.1\|4720772_4721942_-\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	0.000478694
NZ_CP017717.1\|WP_080046859.1\|4718000_4718738_-\|hypothetical-protein	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	1.44672e-33
NZ_CP017717.1\|WP_080039837.1\|4743245_4744175_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176131	cd08440, PBP2_LTTR_like_4, TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.47377e-66
NZ_CP017717.1\|WP_080046860.1\|4731955_4732552_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.18587e-16
NZ_CP017717.1\|WP_155127766.1\|4722109_4726168_-\|hypothetical-protein	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	4.36231e-11
NZ_CP017717.1\|WP_080039830.1\|4728682_4731757_-\|glycosylase	gnl\|CDD\|369609	pfam07944, Glyco_hydro_127, Beta-L-arabinofuranosidase, GH127. One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.	2.86352e-94
NZ_CP017717.1\|WP_155127771.1\|4747087_4748626_+\|tannase/feruloyl-esterase-family-alpha/beta-hydrolase	gnl\|CDD\|284851	pfam07519, Tannase, Tannase and feruloyl esterase. This family includes fungal tannase and feruloyl esterase. It also includes several bacterial homologs of unknown function.	9.75295e-120
NZ_CP017717.1\|WP_155127774.1\|4749968_4752287_-\|FtsX-like-permease-family-protein	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	0.00154616
NZ_CP017717.1\|WP_080039826.1\|4719003_4720731_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200577	cd10953, CE4_SlAXE_like, Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs. This family is represented by Streptomyces lividans acetylxylan esterase (SlAXE, EC 3.1.1.72), a member of the carbohydrate esterase 4 (CE4) superfamily. SlAXE deacetylates O-acetylated xylan, a key component of plant cell walls. It shows no detectable activity on generic esterase substrates including para-nitrophenyl acetate. It is specific for sugar-based substrates and will precipitate acetylxylan as a result of deacetylation. SlAXE also functions as a chitin and chitooligosaccharide de-N-acetylase with equal efficiency to its activity on xylan. SlAXE forms a dimer. Each monomer contains a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold as other CE4 esterases, which encompasses a mononuclear metalloenzyme employing a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine), to carry out acid/base catalysis. SlAXE possess a single metal center with a chemical preference for Co2+.	1.37614e-80
NZ_CP017717.1\|WP_080039839.1\|4745618_4747106_+\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	4.29667e-82
NZ_CP017717.1\|WP_080039838.1\|4744286_4745606_+\|citrate-transporter	gnl\|CDD\|225407	COG2851, CitM, H+/citrate symporter [Energy production and conversion].	1.70692e-151
NZ_CP017717.1\|WP_080039840.1\|4748884_4749913_+\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	2.31102e-74
NZ_CP017717.1\|WP_155127768.1\|4741877_4743182_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.21318e-108
NZ_CP017717.1\|WP_080039832.1\|4734307_4735930_+\|ATP-dependent-DNA-helicase-RecQ	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.99369e-134
NZ_CP017717.1\|WP_080039829.1\|4726243_4728667_-\|trypsin-like-serine-protease	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	6.87501e-21
NZ_CP017717.1\|WP_080039841.1\|4756374_4757319_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.108e-93

>NZ_CP017717.1|WP_080039833.1|4735998_4736652_+|hypothetical-protein
MTGLLSVVLASGLAWLIGSQITYRWDDVKRRRELDLAAVESFYRAYGCFIEVWRLWSAHKRHSQQVTTPDDMQWHCLQRAAAVEGSLEAILIKIVLERRLTDDDLRLLGCFRQAYQSLRESIRADSELRWYASDGDDEAYRRYRAFKALAIYAADLLQSNQTRWFIGKRRTDLPSGRESVGFLLAATDVARTYDWLETAERILDIESLAPRRTGARS
>NZ_CP017717.1|WP_080039832.1|4734307_4735930_+|ATP-dependent-DNA-helicase-RecQ
MTEVSAECERVARRALGLTDLRPGQLAAMTALAQGRDALVVMPTGGGKSAIYQVPALLLPGPTVVVSPLIALQRDQVEALRERDEEAVSLDAGTPAGERRTTFESLRAGETEFLFCAPEQLAKPDVVRDLAAAGPSLLVVDEAHLISSWGHDFRPDYLRLGAVAEALGRPPIAALTATAAPPVRAEITERLGLRDPMEIVQGFDRPNISLTVRRMLDDPAPDIVATVREETGPGIVYTAVRKQTHRLSDLLTDAGVRAAPYHAGLRRSERDDVHGRFMAGDLDVVVATSAFGMGIDKPDVRFVLHAEVPGSPDAYYQEIGRAGRDGDPARAVLFYRPEDLGLQRYFTASVPDLETLTEVAQAVAEAGAGTDRKTLSTRTGLSPRRLTLLLDLLERTGAVRLSARRIEPAPDAPSPETAADLARRLAERRRDVERTRLEMMRHYAETDDCRRRFLLGYFGEQLTDPCGNCDTCLAGTPERRQEETGPFPPHARVEHRTWGPGEVIQRGEDRLTVLFDTAGYRELQLDAVLEQHLLTETSPS
>NZ_CP017717.1|WP_080039831.1|4732626_4734180_+|MFS-transporter
MSTNHAETGVPDARRLRTILIAVCVALMAVIASVTGLNVAQPDMAVEFGASQTTILWIINVYTLTLAALLLPLGAIGDRLGRKPMLVSGLIIFGAASALAGLAPSADVMIAARVLSGVGAAVIMPITLAVITSTFPDEQRGKAIGVWTGVAGSGGIIGMFLSALLVDVAHWRWLFLLPVVLVLVSLGMMRSVPDSRERSGHPFDTVGALASVVAVVGLIFVLQEGPERGWSSPVTLAALVAGLAALIFFVVWELRRADASLLDVRLFRERGLAGGSITLLAVFGVQAGVFVVLFPFLQAVLGWSGLLSTLAMMPMAVLMMATSGLAPHLAARIGARATMATGIALFGAGLALMAGIVSVDGGYPSILPGMLAMGIGMGLAMTPSTEAITGSLPRDKQGVASALNDITREFGTALGVALLGALLASGYRGAVDDRLAGLPQGAADAARQGVANAIEAAGSAGPHARALVDAARQSFVEGWQQAMWAGVAVMGILLVYTAVRGPQPAAKEETPPARVTA
>NZ_CP017717.1|WP_080046860.1|4731955_4732552_-|helix-turn-helix-transcriptional-regulator
MLPMKQEDEDLDSLVRKRIRALRVAQGWSLEELATRARLSQSSLSRIENGRRRLALDQLVTLARALDTSLDQLVETASDDVVISPKIDGTQGWMRWPVKGDPGMTVMRRRLTEPPPDNPARMRAHPGREWLVVLSGTAALMLGHRRIRLEANQAAEFPTMMPHAIGAEGGPCEIMGIFDRDARRGHQRDGGDTRKPGD
>NZ_CP017717.1|WP_080039830.1|4728682_4731757_-|glycosylase
MTASDQPGVSRRTFVRASAVGLALAATARPLPAAARTSAPGAAGIPYVGAGSNTPVRPFPLGEVRLNAGLLQEKRDRMKAFLRAYDERRFLMLFNDQAGRPNPPGLQLPGGWEDGGLLSGHWAGHYLSALAQAYADQGEQVFKDKLDWMVDELAACQAAITARMDTPGGGNEPEEPVIGRVEGRFGKGLRLNGGSGAEHLRLPQEAVSQLTDFTIATWVNLATAQTWSRIFDFGQNTTVNMFLTARSGAAGNPPRFAITVGGSGQEQQITGPSAVPAGEWVHLAVTLAGGVGTLYVNGAAVATNPGMSLDPTSLGVPGNIWIGRSQYGDPLLDATIDEFHIFDRALGAAEVQSLTTSAAGSTGGGNIAWYRFDEDGGSSALDSSPNGRDAGIVPVTQGGGGLWVSTHPGYLGAVPEDAVIRLGPPRFAVYGSNPDTNVWAPWYTQHKIMRGLLDAYTLTGNERARDVVVRMAEWAHLALTVGDKNHPQYEGPITRSDLDLMWDTYIAGEYGGANEVFPEIYALTGDERHLETAKLFDNRESLFGACVENRDILVVTDPAKLGRRRPARLHVNQHVPNFVGYLRIFEQGGGPDYLRAAANFFGMVVPHRMFSHGGTGGNYPGSNNNLEMFQNRDNIANALAQSGAETCSVYNVSKLARNLFFHTRDPAYVDYYERAVLNQIAGSRADTATTGNPQVTYFQPVGPGASRSYGNTGTCCGGTGLENHTKYQDTVYFKSADGSALWVNLFVPSTVTWAEKGFTVTQETAFPREAGTRLRIDGSGRLDIRLRVPAWARNGFTVLVNGTRAPVGAAKPGTYVTLRRTWRRGDVVEVSMPFGIRIERALDRPDTQSVMWGPLLMPIVGDPGSGGYRELSLYRYLKRDGDYARAAITPAGTSPAGDPLFTTHGFTLRPWYVGDTQPHSAYFRRVEPQIVFGSIDSGVPNVRRDDGLPKYDVPVSGIPSPGTDGLTFLDVVWDQAPFATHGAFVSTVARTAAEFVRAGRLTGAQQDAVVAAAASARKELTPEP
>NZ_CP017717.1|WP_080039829.1|4726243_4728667_-|trypsin-like-serine-protease
MPALCPGDALVRVRRDLHNRAVKLQRIIRSLPITTLSLLMVISSAVLWAGATPAQAVRGGGPVTDGTWGFVAKVNVGETHGCTGALISPQWVLTATSCFASPGQPLTSGAPKTATTVTVGRTDLSGTGGRVLPVEWIHPHPTRDVVLVKLTLRAVGITPVTLGSTAPVSGDALQVAGFGRTAEQWAPGLLHAAPVVAGTVAAGSFGWSAASGDVSACQGDAGAPVLRTNGSRAELVGLSSGSGQGGCLGAAADGTRGGDAMRVDDLASWIRTAAPEPTTSFAQYGSSLTGIGGYDLKDDRDQVVAFDYEHSGKLDHLVLYRPGTQIVSIVKRNTDGTYASVFSSTTGIGGYDLKDARDRIIAFDYKGTGKLDHLLLYRPGGETAWILEHGTGTTFKAVFHSSDGIGGYDLKRDEDQIIAFDYAGSGKQDHLLLYRPGIGTVHILQRGGAAFAPVFATVDGGIGGYNMKDVRDRIIAFDYEGTGKLDHLVLYRPGGETAWILEHGTGTTFRAVFNSSTGIGGYDLKSTADRIIAYDYEHSGRLDHLLLYRPGGKTAWILKHGAGNAFTAVFHSSAGIGGYDLEMAKDRMIAFDYRGTGGQSHLFLYRPGDGITYFAGRALPPVRVVPVTVTPVIGQDSIVERYAYPLNFPHAYAGTSGQADWGTDEAEARNFELISGNGGLIWVSCTVSPENGVGVIKVFPGLLNGQTEIGEPHLGVTAVCFKVLGAGGWVKLRIPNVYEVQGDSRSPGAGHDVDATVVNVSSGAERTKRVERDESEQFGRTDTTCDEGHPDYPDNCRETLLELRVVA
>NZ_CP017717.1|WP_155127766.1|4722109_4726168_-|hypothetical-protein
MKTNRALRGTGVVGSVLALLLVGSPITEAAAADPPAAPVCERQVVLEAWVTGGVNVRPAAEQALLGDKAAICAMLAELPRLTAQDDREQVGRIKAHGEAEVAAAANAALRSDDSGAVSKFLDGGWQSAREIDLRAGVNRMKAAGGPEVKAAANAVLRNGSREALGQFIESGWRLPYKLDLRAVVNRAMAEGGPQVQAAANRALQDGSLEMQERFVQIDWGVAQARDNENQTLNDLRASATEATRLAAFETVSAVAQADRAKAEAAAAKADAQDAERLASLAGQESAEAKRQARRAAEAADRAAVASSIAVQAARAAAQAARAAAGAAGRAATAAARAHTKSDEAWAAAAAAELDAKAAADAENHNRVMQQIGPQITAWLSPIDQITAVTQQAYAAVAAADSARANTAAAGRAAEAAGRYAGQASAEAKAAFAAAARAGASAERAKRATEETVRQADIAKDAAGKARDAATRAVTYAEQAASAAKSAAEHAGNAVNAAELATQHANNAYRAAEDALQAAETAQTVYKAARAADAERLKHELELELSFARHVSQKAAEARLGDARGFAAPMRRYHTPEIDALIAEAANPQADIATAARKAREVARYFATVPGTWTSSAAMAALGEDDDVRTVAFVKTGLAAAEEQDDRTTLTGLMPTGTPAMRAAAQQALDGAWADVVAFLDDPDYPELAAEQREQVGRILAEAREAGHAQTEEAANLALRSDDPGALQEFLDVKHNTAYTMDIRSKVGAIAGDASNGTEVRNGAQIALAGTTAMQAEFLEVERHRAAERDYATATHNYIATSLMIETSEIAQRAVDFARTAQAAAAEARGAAEEAIGYANAAGRAADQARTYATEAVAHARDAAASAERAAQAVRTAAAAAQQAQQSAGRASLSARWARASAVSAAQDAAGAYAAYDTAYAAQIRAGNSASEAARIAAEVFDHYREEAQRRLNTLKGEWLGHCKWGPEDGLPGYHDCSAYVEDILNDPKGPLHDPDGYAHANAEQCRRQFVGKALDACLSVVMSPLFSAAKTGISDRETETHRLAEEYISLTALDLFNAAQQYGMISDCKSAFKGALSGRVSSFSDCITGAFDLSEDPNWNENASQWKGTFVESLIPEELRFAEYNSIWGPMYLLHHMSDRTIIVATYESSLATSLVRMLPIGCVQEGGQCPYADAASKLRDVSESIKQLNNQGYIVDESGRVLDANGLPIASLPPADDLSKWANYTVESGLHDDLAALENRLDLLYRQQFGLPMAPPAWHLETQLAYRVATREVALRDSTLRLVMNNPGGVCDAVPLTGTGPDRQRQAVAGCIQAVKMLLPAGTTMIIYYPDPDDPAELLEITVRGVGRWLD
>NZ_CP017717.1|WP_080039827.1|4720772_4721942_-|right-handed-parallel-beta-helix-repeat-containing-protein
MELGRREAVKLGLAALAGGGVLRMAPAAHAAGAVNTYPAGEDSVVVALRRALDNAANGIAGPAGRDAQGRIIVRATANHRHVLKGRLIVGGNTHLDATNARFVAAFTSPGTSETMVLNHVPSATTGRYDAPGTIRITGGSWDPIWQYLQDGRTPPPSNVITMQHTSGVELVGLTIYNVKWYHAIELNAVRNATVSGCALYGWVLDPQYADKRYHGEAIQLDLAGAKNTWAGARDNTPCTDIRVLGNTCDKSGSQGPWGTLVGSHTAVPGVRHSRVWIEDNVVDNTSYDAITPFNTEAVHIRNNRITGCNGGVYVRASETEANPLTTVEITGNTVGPLVPDYQGKIRSGIGLVAHEGSPISDILVSGNTAPSFIYRSRQLMTFREPPQTS
>NZ_CP017717.1|WP_080039826.1|4719003_4720731_+|polysaccharide-deacetylase-family-protein
MRGNRWRTIRGLATAAILGAGVSLVALPGPASAGTPAIDRPRCTGYVGLTFDDGPTPGNTPALLKALKAAGLRATMFNVGQNVQANPQLAKDQVAAGMWIGNHSWDHPYMTRLGAEEQAAQISRTQDAVKAATGITPQLFRPPYLDTDDALRAVERQYGLTEINADVDSQDWNNATAAQIVASARKLQAGDVILMHDWPAATVEAVPRIAADLRRRGLCAGMISPDTGRAVAPRDVLAQAHTAGRVQDLGTSVRYTWPGVSFEGRFRGTGVGIVLNDAANDYDVQVDGAAPATLRTPGRTTYWVSGLRDGTHTVRVAKRTESPWQPGEFGGFVAAPGGRVLDGPAPRARQIEFIGDSWTAGYGNMSTVRDCGATGGVNPNSNADQTFGALTARGLNADYQLTAWSGMGMVRNYNGGNPGTTFRTFYDRTLQAADLEVWQPPRGWRPQLVVVGLGINDFSTALNPGEPWADLDALAADYRAAYLGFLDTLRARYGKSTYIVLTYPTMSNTTALADSVQQIVRQRNAQGDGRVKALHYDNAALGLDLLGCDWHPSLHDHKALAGALGSFIATLPLRW
>NZ_CP017717.1|WP_080046859.1|4718000_4718738_-|hypothetical-protein
MKPGLVISTPVEYRHGSAVMEGLLLHGDMIPEPAPTVLVCHGAEGRSDVLVQMSVRLLRWGYQAFVMDLYGKGVTGSTAEEFDALMRPFLQDRAMLADRLSTVVATVAGLPQVDASRLAAIGFCFGGLCVLDLARHDAAVRGVASFHGVLTPPPGWTPRPTSCKVAVYHGWEDPFARPDDVTALAAELTAAGADWQLHAFGHTYHSFMAEQADSPELGIRYSRRSAERAWWSLERFLAECLRDPS
>NZ_CP017717.1|WP_155127768.1|4741877_4743182_-|CoA-transferase
MKLRRAGRIRAAEAVAGRSRAGRGRAGRSRAGRRSRCVAVEQRGQLRGLKVVEFAHVVAGPLAGSLLADQGADVVHVEPPGSGDAARAMGPTRDGVPLWFKVAGRNKRSVTLDLHDPDGREVAQRLVAWADVVIVTLRASRLRAWGLDWDSVHRINPKAVLLQVSGFGAQDDAPGFGKVGEARSGVVHLTGFPDGPPVHTGFSHGDAVTGLMGAYAVLAALHRRANDPSFDGEWIDLALFEPLFRLVEWQVITHDQLGVVPGRSGNQLAVAPAAVINTYLSADADWITVTSATLRSVLNVVRLLGLPEQEYATTAQQLAGRERLDAELRAWVAARSTEECLRAFAKAEVVASRVFTAADIVADPVYAERGDIVTVDDPDLGPVRMQAALPHFRQAPGHIWRTGPALGEDNALVYRDWLGLPADELAELERRGVI
>NZ_CP017717.1|WP_080039837.1|4743245_4744175_-|LysR-family-transcriptional-regulator
MDTSLRQLAAYVAVAQAGGFTAAAARLRVSQSTLSRAVSDLERVLGVRLLERDTRNVQLTAAGRETLRVAEQIVDAHRSGMKQLRRYLLGESGVVAMATLPSVAAVLLPRLISAFRGRRPGVSVRIMDGLERAVLGKVLNGDADFAVTTVGAASDRLEHRPLIRDRFRAVLPESHPLADRDEVTWEDLAAQPFLAVGPESSVRRLTDAAFEQAGAVVAPAAEAGNVATVGGLVAAGLGVSAMPALVLPLLGPGHVVHRTLVGPAVERRLDIVVRARRTLPPAAAAFLDLLDEARTEGREVPEGAAWITH
>NZ_CP017717.1|WP_080039838.1|4744286_4745606_+|citrate-transporter
MIAILGFLTIGLFLVLTMTRRVSVLTALVLVPVATALVGGFASGMGPMILEGLGKVAPTGIMIAFAVLYFSLMIDSGLFDPLIRGILRLAKDDPLRIAVGTAVLTMCVALDGDGASTFLITVSALLPVYKRLGMSPLVLTGVVALGAGVMNMVPWGGPTARAMAVLKLDASQVFAPVLPAMVAGIAWVLVAAYLIGLRERRRLGAASLPAEPQPEPEPVRGDGPGTQLAPERRSTALTVFNLVLTVVLLVALVLQVMPLPVLFVLGFAIAAVVNLPTWEKQQALLDKHAKSVVLVTTMIFAAGVFTGILNGTKMIDQMATAFVGVIPDSFGGHLPLLVAITSMPLSLVFTPDAYYFGVLPVLAQTAAGFGIDSAEIARAAVLGQMTTGFPLSPLTAATFILVGMSGVQLGQHQRFIFGWAFATTAVMTVVALLTGAISF
>NZ_CP017717.1|WP_080039839.1|4745618_4747106_+|CocE/NonD-family-hydrolase
MTYGHVLAALSTAFTTLTAPAAPADPFFSYERPATYEVRTERVQVPLRDGGHLACDLHRPAAEGRFPVIVYDYTAYDQLETLGRAAAWFVARGYNAAVCNARGSGDSPGHLDPFSAQEQRDNYDLIEWLAVQPWSTGKVGQTGVSYGGHSSLLVAVNKPPHLAAIIPVDGISDWYENTIYRGGIYSARIRDWQRAVAPDTLTTYAQHPLYDDFWRERSVKARWKDLDVPVLEIAGWYDRYRQAMVDNFRARPRNVWLVAGPWQHGWPAGQPADIGNGAYLAWWDRWLGGRRDAPLPAAKVTSYEAGAGGGWKSWSTWPPPGARRERLGLGGDGTLTPRPGAPAVRRFAVNTDEAPATPDERLTFQTQPYGSDLVLTGEITAEVRAAFTATDGNIAVVAEDVRPDGTATRITQGWLKASHRFGHTRAVPVRPGKTYDLTIRTWPTHYRLAAGHSLRVTVSSDDYPEIDSDAPAGHVDLRLGRGGTGITLTTWTEPR
>NZ_CP017717.1|WP_155127771.1|4747087_4748626_+|tannase/feruloyl-esterase-family-alpha/beta-hydrolase
MDGAAMTRLRAFLTAIAVLSVTLVPGTPATAASGGRACENLTAVRLPHTTITTAESVPAGAYTAPDGRALPSVPAFCRVHGVARPVPGSTIGFEVWIPRRWNQRLLMYGNGGYSSAIDFPSMGGAALAAGYATVGTDTGHTGDDPDVFVQGAANPEIIVDWGHRAVHETIVNAKLLVEAHTATRPRYSYFVGCSTGGHQALMEAQRYPDDFDGIVAGAPGNNRVALNAGFLWQFLANHQPGDDTAPIVPAAKLPLLTRAAVEQCRSGTDDFLTDPRRCGFDPAVLRCRSGDAPTCLTARQIEAVRTMYAGARDPRTGKQVYPGWPVGSEAPVVDAAGTVRSGWSGYWGGTEPARANFWRYWVFGDPGWNWWDFDYHRDLRRAQDKLGRVIDATDPDLRPFRRSGGKLLMYAGWADPVVSAYDTIDYYRRVVAVTSGGRARDTATFARLFLAPGMTHCGGGPGPNTFDKLTPIVGWVERGTAPAEIPATKYVNDDPAAGVVTTRPLVPFHMTG
>NZ_CP017717.1|WP_080039840.1|4748884_4749913_+|nitronate-monooxygenase
MSVLSTRLTEKYAIPYPFVCAGMSFVAESPEFAAAVTNAGGIGAIGAALLPPERLREMIREVRERTGGRPFHVNLITFFPTGELVEVCAEERVPIVSFHWGHPPADQLKLLREAGVSVWEQVGSADAARLAVDDGAELVVAQGWEAGGHNYGGLPTMVNVPAVVDAVGGRALVLAAGGITDGRQVAAALCLGADGVWVGTRMVASQEARVHPEHHRRLVAAAGDSAVLTSIFGLEFPRFNPMRLQRNRVVAEWDHRLAEIPADLDSLEQVGTTVVQGEPVPVRKFPLMLAVAETEADWEEMPWLMGQGVGLIHDIKPAARIVADMMEQAERVLTGFGTGPAT
>NZ_CP017717.1|WP_155127774.1|4749968_4752287_-|FtsX-like-permease-family-protein
MKTPAPRRPGPGRTPAPRRAGAGVFTALRRAGGVRIPVPHWPSVAGRARADAGPLLLAAVVVAVVTLLAGAVPPLVSATADAAVRDAVRGSGADLQVHARMEADDGPGGSRARHPRLAEDVDDFRTRATDELGPGLRAVLRPPVATVISPTLKITDGSVLRTFQLAYLARDGGPAVSWIAGGPPEPTASETAQVPYGAPPWPVQVGLSEADAAALQLRPGARIPLADDQGNVKKAQVSGIFRPQDSADPAWRLVPALLSPVAGADGTGGTRFAGLLSRESLPDARLAFGQDELRRTVRFTPEPARLTWDAVPSVIAKVVALKAASGSSGARDGSLKWETGLDGVLRNVSAQVGAAFAQASVLLLTLLAVAVLVLLLAADLLVRRRAGALAAARQRGMSLPVIGGELLLESAVMALLATAAGLGLALAVAPGVSWQWTAPVVVTAVAAGPAFGTLTAARATRDRRVPANRSARRWLRNTARLRRAAVEAGVLLAATGAAVALYQRGVGGGVLPASAPALCAIAGALLLARALPVGTRLVLRRLLRSRRPLAVFGAARAAAASARVLPLLVLVTAAALASYALTLGAALGHATALGHATALGHATALGHATALGHATALGHATALGHATVDSPLASGLLRLTWVAAVTLPVLGLLGLALGTAAGAPERWQTLTRLRTLGLRPREARWVAAGELLPPVALAAVGGPLLGVLLARLTFGSLALPLLTGADFTPAPPWWALGLVAAVLLAAVAVVVPVESALRRRRRLSEVLRAGDT
>NZ_CP017717.1|WP_080046863.1|4752283_4755403_-|ABC-transporter-permease
MLAALLAVAVVGPTLLGTCALLLTRTAEQALETAAARAGADQVDVTAYTVTIRGEHARSVADDTRDVLTSALAPFAATTAARASSVMRALPGAGVPSVAYLSGVADLPSRAQLVRGRLPRAGAAPAEAVVLESTARRLGLAAGSRVRLGRELADDPDESAEVRVVGIVRPLPGTGWDRDPLTGTGFDPAYRDGRSAQPVHAYGPFLVDLADLLGGGSTLDRLEITAHPDLSAATVRDLDAVTQAVLGADRRLGRTLGDRVRIQRVASRLPATLLAAHDQQRVTTAAVLAVAAIGLVLTATALALAGRLSAGVRAGETALLSALGVGRGQLAGAALAEAGALAVLAAVAAIPASSALHAGLTRLAPMAEAGLAAPAGVNAAQVLSVAGAALALAAVLVVPSLRAPSAAGVRGRRELLARSGADLLLVALAAVGWWQLRDQPAGSGSPVDAVRVLAPALLLIAGSAVALRLVWPALRLVERLARRARGLMVPLAAFEAARRPQAVAAGLLVGLGCAAATYGIGFDATWQRSQQDQADLSVGTDLAITLTAPPAAGQGPLVGAASGGEVSPATDRGIAVGQWLGGAGDPPRLIAVDTTRAGALLRGRLDGGRTWSAVGARLAPPARAAGVPVPAGAALTLTGNATGPTPLTVTPRLLLQDATGLRTPCTGAPVPLDGRAHPLPDCATAGGLRLVAVSLPFAIDTGNVGTGHSAWTEAPAGDSRVAVTLTVPGTTGETPQWTATSAGPAPGQLGNPAVALTGTSAGTKLRMTTTVALKGPPDAARNLVATAFPAPGPVPVAVSARFAEEAGARPGSRLDLTVGLTPVRVSVAEVLPAVPSAPGAAAVLADFDALSRALAVSGDFDVPVDAWWVGRPAKTDLRLGGVTTRASETARLTGGPLQAGLPAVLRLLVPAAVLLMIAGIVLHVTFDLRARAVEVARLRGLGMTRREIRAVLLGQHVGILVPLLAVGAVVGALATRVVAPLLVRSDTGAAPVPEVLPVWPWAAEAALLGGLLAGSALAVGAVVAVQARRADAAHLRVAS
>NZ_CP017717.1|WP_080039841.1|4756374_4757319_-|ABC-transporter-ATP-binding-protein
MRLAKTGTPLSLPQPPAKAPEFGRDALIVCESLVRIYQSGSVEVQALQGLDLVVDGGEMVAVVGASGSGKSTLLSILAGVDAPTAGRVRVDRWNLLDMSRADRVRYRRHTVGFVRQQTAANLIPYLTARQMVDLPMTAARTPGRVRRKRAAELLGLLGVADCADRRPAELSGGQQMRVAIAVALANEPRVLLADEPTGELDSATSAAVFGLLREVNRRLGVTVVIVTHDPAVSGQVERTVAIRDGRTSSEVLRRTATGDDGAQRVIAEEYAVMDRAGRIQVPRDYREALALTRRVRLVLEADHVAIRPDGGEAG
>NZ_CP017717.1|WP_155127777.1|4757403_4758579_-|alpha/beta-hydrolase
MIRTRRDSAALLLALTLALPVTAATMSAPAAADVRLAIPHPTGRYDVGRDTLHLVDTGRRDPWVPTAARELMVSVYFPARTGGDTAPYMTLEEARLLLEGQKLDRVIKPGQLAGVGTNAHLSARPVGGRHPLVVLSPGFTLNRATLTTLAEDLASKGYVVALVDHAYESFGTSFPGGRTLTCVACRTVESAPSDDAEKELMGKAAAGRAADLSFVIDRLTRPRRSAPAWKHWQMIDPRRIGAAGHSLGGNAAASVMATDRRVRAGANLDGSFFDPVPAKGLGGRPFLMLGTKAQHSPGSADTTWPRDWPRLNGWKRWLTVADAGHFTFIDLPVLGAQAGITDPSAPLPGKRSGEITTAYVGAFFDQHLNGEHQPLLDGPSPANPEVTFQNP

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Crispr_ID: NZ_CP017717_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_10

5187702-5187902

Orphan

Consensus_repeat	Method
GCGCATGCACCCGGCGACACGGTGCGGGACGGGGTGAGCGCGTGCGCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_10

>merge|NZ_CP017717|10|5187702-5187902|CRISPRCasFinder
GCGCATGCACCCGGCGACACGGTGCGGGACGGGGTGAGCGCGTGCGCCCGGCGACCGCGTGGCGGGACCGGAACGGGCGCATGCACCCGGCGACACGGCGCGGGACGGGGTGAGCGCGTGCGCCCGACGACCGCATGGCGGGACGGAACGGGCGCGTGCGCCCAGCGGCACGGCGCGGCATCGCACGGCCGCGTGCGCCCG

>NZ_CP017717|10|8|5187702-5187902|CRISPRCasFinder
GCGCATGCACCCGGCGACACGGTGCGGGACGGGGTGAGCGCGTGCGCCCG	GCGACCGCGTGGCGGGACCGGAACGGGCGCATGCACCCGGCGACACGGCGCGGGACGGGGTGAGCGCGTGCGCCCGACGACCGCATGGCGGGACGGAACGG
GCGCGTGCGCCCAGCGGCACGGCGCGGCATCGCACGGCCGCGTGCGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080040197.1\|5190806_5192087_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP017717.1\|WP_080040195.1\|5182778_5183999_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270451
NZ_CP017717.1\|WP_080040191.1\|5178446_5179277_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP017717.1\|WP_080040194.1\|5181790_5182774_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080040196.1\|5183995_5184961_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP017717.1\|WP_155127901.1\|5192234_5197253_+\|DUF1349-domain-containing-protein	unknown	unknown	gnl\|CDD\|377643
NZ_CP017717.1\|WP_080040190.1\|5177202_5178438_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP017717.1\|WP_080046905.1\|5175527_5176280_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_155127907.1\|5199051_5199672_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP017717.1\|WP_080040188.1\|5174769_5175516_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|179510
NZ_CP017717.1\|WP_080040203.1\|5200942_5202139_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP017717.1\|WP_080040193.1\|5180978_5181794_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080040189.1\|5176327_5177212_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080040192.1\|5179294_5180935_+\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|277357
NZ_CP017717.1\|WP_080046906.1\|5188135_5189143_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP017717.1\|WP_080046908.1\|5202288_5203419_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP017717.1\|WP_080046907.1\|5189257_5190457_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP017717.1\|WP_155127904.1\|5197978_5199022_+\|DUF916-domain-containing-protein	unknown	unknown	gnl\|CDD\|368712
NZ_CP017717.1\|WP_080040202.1\|5199748_5200867_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236196
NZ_CP017717.1\|WP_080040199.1\|5197286_5197928_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080040197.1\|5190806_5192087_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.6188e-51
NZ_CP017717.1\|WP_080040195.1\|5182778_5183999_-\|extracellular-solute-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.78904e-64
NZ_CP017717.1\|WP_080040191.1\|5178446_5179277_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.9563e-67
NZ_CP017717.1\|WP_080040194.1\|5181790_5182774_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	8.41407e-80
NZ_CP017717.1\|WP_080040196.1\|5183995_5184961_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.08982e-87
NZ_CP017717.1\|WP_155127901.1\|5192234_5197253_+\|DUF1349-domain-containing-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	2.59216e-100
NZ_CP017717.1\|WP_080040190.1\|5177202_5178438_-\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.59057e-63
NZ_CP017717.1\|WP_080046905.1\|5175527_5176280_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.26613e-73
NZ_CP017717.1\|WP_155127907.1\|5199051_5199672_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.13633e-07
NZ_CP017717.1\|WP_080040188.1\|5174769_5175516_-\|SIS-domain-containing-protein	gnl\|CDD\|179510	PRK02947, PRK02947, sugar isomerase domain-containing protein.	7.3188e-101
NZ_CP017717.1\|WP_080040203.1\|5200942_5202139_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	4.47448e-60
NZ_CP017717.1\|WP_080040193.1\|5180978_5181794_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.39791e-77
NZ_CP017717.1\|WP_080040189.1\|5176327_5177212_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.23807e-71
NZ_CP017717.1\|WP_080040192.1\|5179294_5180935_+\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|277357	cd07412, MPP_YhcR_N, Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain. YhcR is a Bacillus subtilis sugar-nonspecific endonuclease. It cleaves endonucleolytically to yield nucleotide 3'-monophosphate products, similar to Staphylococcus aureus micrococcal nuclease. YhcR appears to be located in the cell wall, and is thought to be a substrate for a Bacillus subtilis sortase. YhcR is the major calcium-activated nuclease of B. subtilis. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	7.75515e-97
NZ_CP017717.1\|WP_080046906.1\|5188135_5189143_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.16454e-33
NZ_CP017717.1\|WP_080046908.1\|5202288_5203419_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	2.30048e-58
NZ_CP017717.1\|WP_080046907.1\|5189257_5190457_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	8.15835e-51
NZ_CP017717.1\|WP_080040202.1\|5199748_5200867_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	8.76748e-140
NZ_CP017717.1\|WP_155127904.1\|5197978_5199022_+\|DUF916-domain-containing-protein	gnl\|CDD\|368712	pfam06030, DUF916, Bacterial protein of unknown function (DUF916). This family consists of several hypothetical bacterial proteins of unknown function.	7.68729e-08

>NZ_CP017717.1|WP_080040196.1|5183995_5184961_-|LacI-family-transcriptional-regulator
MASKVTIADVARYANVSRQTVSNVLNSPEVVKEETRQRVLDAVEALGYRVSAAARQMRTGRSRLLAVRIETTQDGMNVFDRFLHGLTESAARSGYRVLLYTAADDRAEIDTIDQLLGEFEPDGFVLTSTHHGDPRAAWLAGRGLPFVSFGRPWGAPEGVHPWVDVDGASGTETATRHLLDAGHRRIGFIGWEPGSGVGDDRRAGWERTLAAHGLDAGLVLETDGSSAQGQAAARELVERGATALVCVSDSVALGALQVVPDVVGFDDTPVAAAVGLTSVSQPLTEAAARCVELLTSRLSDRPAATHVLLTPSLVIRKEPRS
>NZ_CP017717.1|WP_080040195.1|5182778_5183999_-|extracellular-solute-binding-protein
MKSLTIPAAMAVLLSLTACGSGFDDRQPAPQQSAGPAALQILMASSGDAETNAVKQAAQAWAKASGNTATVTPAQDIHQQLGQALAGSNPPDVFYVDASRFADYASVGALEPYADRISASQDFYPKLRETFTYDGRFYCAPKDFSTLALVVNDELWKKNGLTDDDIPTTWDELTAVTKKIKGVTPLVFGDTRDRVGVFMVQAGGWITSPDGKQATGDSPQNLAALEYVKGLLTAKQAQYARALDADWGGEAFGKGKAAMTIEGNWIRGAMQADYPDVRFSVHELPAGPKGKGTLSFSNCWGISAKSRHKDAAISFVEAMTKADQQLAFARAFGVMPSRQSAKDAYLKEFPGDAAFVAGADYAQGPVNAPKMDSVLSDFDSGLQKLATSDPKQLLARLQKNTESVRG
>NZ_CP017717.1|WP_080040194.1|5181790_5182774_-|sugar-ABC-transporter-permease
MRSRTRENLAGWLFVAPVVAILGLFLLLPILMALWVSLTGWNGQGSPFRAGVPFVGGDNYARLFTEDGLARENFMTSLRNNVYYVAAVVPLQTALALFLALVVNRRRAFFRTAFYFPSVTSSVAISVVFLFIFSNSGAVNQLLALAGVRGPQWFSDPRGVIQLLIGEPPAALTEHGLLGLTWWDWLAGPSVAMCAIIVLVVWTTSGTFMLMFLAALQNIPKALDEAAMLDGATRWQRFRRVTLPMLKPTMFLVLTLGLIGTWQVFDQIYVMSQGDPAKTTLTPAFLSYRTAFRDFDYGAGTAISFVLFLIIVVLTLVQRWVMRERKA
>NZ_CP017717.1|WP_080040193.1|5180978_5181794_-|carbohydrate-ABC-transporter-permease
MKAMRGILLAVFSVVFVYPFVIQVANSFKTDPDAAANPLSPIPHPATLSAFERVFLGTDMPVWLANSLLVTVVVTLGRVLLDSMAGYALARLRFRGRSGLFAAVIAVMAVPGVVLFIPKFLVLNQLGMYDSYLALILPLVADATGVFIMKQFFESIPGSVEEAARIDGAGPFRVFWSVVLPMSRPALITLTILSFQGSWNEFPHTLVAVQDPALFTLPRGLADLVSGSLGGGTQFPLKLAAALLATVPVAVIFVVFQRHFIRDPNQGAEKG
>NZ_CP017717.1|WP_080040192.1|5179294_5180935_+|bifunctional-metallophosphatase/5'-nucleotidase
MRNFLIALVLGGTSLLPARAETVDIQLLAFNDFHSAFPSSFATTESGPVPAGGAEYLAAHLDRLQRDNPRGTLRLSAGDNISSTTMNMTALHDEPAIEALNLMRLDASVAGNHEFDEGLAEFRRMENGSCHPIDGCAVPGFKGADFPYLGANLVDTTTGKPALTPYVVKEVKGVKVGIIGVDYKNALKEAPGPTAPLEGRDEAEAVNTYTAELKAKGVRTIVVLIHQGGGQTGGGLPNQCNNLAGPIKDIVQRFDPEVDAVISGHTHNPYNCVINGIPVTQTSAHTRELTKVVLTVDRATGNPTAAKAENVTVTHDIRPDARIAALRRTYDQQGQKLLDRPVGLLARDLTATRNAAGESTIGHALADARLFATAAPENGGARIAIQPPYGGGIGGDLIVNPTGNEMSNLVTHGKALRVQPFSNMLVTMTLTGAQVERLLEQQWCGQSTARVLGVSQGLTYTYDNARPACDKIDPATIKLDGAVIDPAASYRVTANSFIATGGDSFSVLTEGTERVEKVRDIEAFESYIRAKSPLQAPALGRVTRVN
>NZ_CP017717.1|WP_080040191.1|5178446_5179277_-|MurR/RpiR-family-transcriptional-regulator
MPTLTATHRRIAEAILAEPAAVAASTIGELAERCGTSLTTITRFCRELGLSGYPELRLALAAELGRNDAAPREQGLIAFSPDDPSSLVLRSLLASDMRAMEETAAQLDLEAVDRAVTHLVGARFIDFFAVAGSAGVAMDLHLRLHAIGRPCALWSDVHNAICSANARDERDVAVGISHSGTTAEVVEPLTIAKERGATTIAITNFPRSPLAETADIVLTTAAQDTPFRAGGVAARHTQMLVLDCLYIGVVQRTHETSDQLLTAATGAVAQHRLSPR
>NZ_CP017717.1|WP_080040190.1|5177202_5178438_-|extracellular-solute-binding-protein
MRLAAAALALAMAVTACAPSTTTSADEGKVTLSVWGWGPEENFDKMFAEYEKLNPGIDVDARSFTTSTEYDTILSTGLAGDSGPDLAWLRAGPQLQPLVEAGRLLPLDTKTVPGLADFDENVLRAAKGDKDGKTYGVPFAVQTLQVIYNKKIFAEHGVTPPKTYDEMIAAAGKLKAKGVIPFAFGGKDDWMLPIVASIFGTAHWGGDAFLADVKAKRKTFTDPRFVEGIDQLNQLKPYFPDNAAGVSYTDAQMLFSAGKAAMFPGGLWELNFFTENAPGVELGVFTPPAPDGPGLMPGFTDGSYGVNIKTRHQAEALKFAAWLASKDYGRLYTDTLRTFSAVPGVTPKDPLLGEVATTFDQHGATYFMNEFAYGNPTSATVFAKALQEMLLGRVTAKQAAEQLDKSVSTWL
>NZ_CP017717.1|WP_080040189.1|5176327_5177212_-|sugar-ABC-transporter-permease
MALGARRGSSYLFLIPAFLLYSAFVIYPLFTGLSYSFFSWKGTLRAGFAGWDNYAGLLAGPFLDQLLPALGHNALLFVGTMLVQNTLGLAFAVALSRVRRGKRALQTMFALPYLVNPLVIGYLWTLLLSPAFGPVNALLEPLGLAMPWLGDPDTALPTVILITTWQWVGFPMLLFSAALGGIPPEYAEAARTDGASSWQVFLRITLPLLKPAMATVTILSFIGSMGTFALVYALGGSNGAPAGATDVLGLLFYRTAFASGDVNAIGTSSALAVFMFTFIFGSTLLLERVLRRRA
>NZ_CP017717.1|WP_080046905.1|5175527_5176280_-|carbohydrate-ABC-transporter-permease
MAPLLVMVLSSLRPTSEIFDRPLGWPTGLGNYAKAWTQASFSTYVVNSAVVVVCSVLLGAAVSLLAAYPLGRAAFRGRGLFAAYFVSGMTLPAHLGVLPLFYLLQSMGLVDSPAGLVLVYAAGSVPFNVFVLTAFFRQLPHELDEAAALDGAGPLATFWHVMLPLVRPALATVVVFQFVPIWNDFFYPLILMRDESKLTLPVGLTHFFGQFQNDWGTLFAGLVMTTIPLVVLFVLATRHIVAGLTAGMNR
>NZ_CP017717.1|WP_080040188.1|5174769_5175516_-|SIS-domain-containing-protein
MDLVMSFADEARARLDRLTTGQLPAIRQAGALIAATVRAGGVLHAYGTGHSEAVALEVAGRAGGLIPTNRLALRDPVVLGSADPGAFDPLAERDPATAHQVLALHTIQDHDAFVVASNSGGNGSTVEMARLVKERGLPLIAITSLEHSRAITSRHPSGQRLFELADIVLDNLAPYGDAVLPTEHGPICGISSITSALIVQFMVAEAIGLLLADGTVPPVYLSANIPGADAHNDALVARYAGRIRIGAL
>NZ_CP017717.1|WP_080046906.1|5188135_5189143_-|sugar-phosphate-isomerase/epimerase
MTRPITLFTGQWADLPFEEVCRLASEWGYDGLEIACWGDHFEVDKALADDSYIERKKETLAKYNLGVWTISNHLVGQAVCDHPIDERHKGILPARIWGDGEPEGVRRRAAEEIKNTARAAAALGVTTVVGFTGSSIWHTLAMFPPVPPSMIEAGYADFADRWNPILDVFDEVGVRFAHEVHPSEIAYDYHTTVRTLEAIGHRPAFGLNWDPSHMVWQDLDPAGFILDFADRIYHVDCKDARVAGRDGRRGRLASHLPWADPRRGWDFVSTGRGDVPWETCFRALNHIGYDGPISIEWEDAGMDRLHGAPESLAYIRSLNAITPPAASFDAAFSSE
>NZ_CP017717.1|WP_080046907.1|5189257_5190457_-|ROK-family-transcriptional-regulator
MLRHVSTHGPCSRSAVAGATGLNKATVTSLVSELQARGLVKEMGPQHAGSVGRPGVALGLDGSRVGALGVEVNVDYIAAIATDLAGRVLIDRRIGFDAMGSGPERSLDELARMVERTVADLDRLGVRPAGITVAVPGLIDTTTGTVVVAPNLGWRGVPVAERLSRAGRAAGIPIAVANDANLAALAEYTTGVAAGTDDLVYLTGEVGVGGGVIAGGRLLSGADGFAGEVGHVMIEPDGEPCRCGRAGCWETKVGLAALVRMATPEHAYGTGLVRDPEERLAEIEQRRAEGDPRVDAAVAEVGRWLGLGAAMLVNIFNPRVIVLGGYFARLADRLIPAAHEELARAGMNGAIERCHFAASDLGFGAAARGAAGVVVERALSDPTSITVPSLVPPQNVPPA
>NZ_CP017717.1|WP_080040197.1|5190806_5192087_+|ROK-family-transcriptional-regulator
MTYKPPRTRPPGGAPPAGAAALRRANLSLVLRELREHASLSRAHIAEATGLHRATVSNLMAELLERRLVREVGVEHVGAIGRPRRAVALHGAHVGALGMEINVDYIAVHGTDLSGRALVERRVAYDAMGSGPDRAVRRLGLVAKEAVEAMRRAGAAPAGVAVAVPGLVDVARGVVTLAPNLYWHDVPLADQLAGMLGTPAVPVRVENDANLAALAEYTSGVAAGTPYLVYLTGEVGVGGGIILGGELLRGADGFSGEVGHLQVDPNGARCGCGRVGCWETKVGLAALVGAAMPEQAYGLPGRPVPDPGERVADIARGLAAGDRRMTMAVAQVGEWLGLGGSILANLFNPRVIVIGGYFASLAEWLLPHAQDQLQRLMVAAPAAQCRFVASTLGFGAASRGAASMVVSHLIDDPTTLMDALPRPAPR
>NZ_CP017717.1|WP_155127901.1|5192234_5197253_+|DUF1349-domain-containing-protein
MSPRQRTWARLLGSAPRAGGRRPRRRTAATAVLSMAAALIVPFVTLSPAPAGAEAATTTAAEPAFKVLVFSKTTGFRHDSIPEGIAAVQKLGQDNNFTVDTTEDSALFTDQNLAQYQAVIFMSTTGDPLSTQEQKDAFQRYIQKGGGFVGVHAAADSGYNWPWYGKLVGAYFKQHPAIQQATVKVEDPAHPSTKDLPTTWTRTDEWYDYQANPRATVHVLTSMDEKSYTGATMGADHPITWCQDFDGGRSWYTGLGHLKENYSEPNFLKLLLGGIQTAAGAVKADCSASQSSSFEKVTLDDNTSNPMMVDVAKDGRVFYIDRLGEVRIIKPAGGTVTAAKLNVFTANESGLLGLALDPAFDTNHWLYLYYSPAGTNVDRLSRFTVTGDTVDLTTEKKILDVPVQRAECCHHGGGMVIDPKTGNLWLATGDNTNPFASDGYTPIDEQQGRSSWDAQRSAGNTNSLSGKLLRIHPEADGSYTVPDGNLFPPGTAKTKPEIYGMGLRNPFRMGLDPKTGHIMLGEYGPDAGTASATRGPQNTVEWNLISKPGNYGWPYCVGNNTPYVDYNFATKQSGSPFNCAAPVNDSPNNDGLTTLPPVIPATVWYHYAADPQNFPEMSGGAPMGGPVYRADPNLQSDVKWPAYWDGKAIFGEWNNDKVWSFQLDETGTKLVEMNPILGSLTFKKPMDMKFGPDGALYMIEWGSGFGGDNADSGIYRIEYTKGTRPPIARAAADKTDGPLPLAVTFSSEGSRDPDGKPLTYAWDLDGDGDTDSTDPNPSYTYTEGGDYNAVLTVKTPDGKTATAGVEISAGNTRPTVSVNLPPNGAFFEFGDQVKFKVTVTDPEDETIDCDKVTIQAILGHDSHGHPLDQHKGCEGVLQTQQAGHGEYDNLFYAIEASYTDGGANGAKPLTGRGQVLLEPKRKQAEHFSRTGRVADGKGTDTAGVQAETTSDPQGGNQHIAFVQDGDWWSFDPANLTNVTAIRFRASSGGAGGTVQVRAGNPETGTLIGSVEVPPTGGWQTFTDVTLDLSSPPTDSGPLYFVVRKPASAADNAYLANFNWVDFVGKGATDNEHPAVTATATPATGVAPLKVNLKATATDPEGDPITYKWNLGVAGAPEPTTAETSHTYDAPGTYTAVVTATDDKGASATAQVTIKVDAPATVCFTGRSDDFLGSQLDRNRWSVVRENQDLKVANGKLVIPTSTTDIYSTGGNTPNIVLQPAPSGAWTATAKLTLDARDAYQQAGLIIYGDDDNYAKMVLQARSTSGSDHASRIFQFIREENAAPNEVSQSNTANLGDSYPDTVYVRFVSDGTNITAHYSADGSTFTAMPQTKPLAGITNPKIGLLSLAGAGHPVVDAAFDWFHITPDDTATAPDPDDEFDGTALDTCRWSAIVRPDATAARVKDGKLELDTTTGDIYGTTNSGPKNFVLQPAPNGDWTLETKVDASALNEQYQQGGLMVYAGDDDYVKLDFLTTNAAGSAVARAIELRSEVGGTVQSPQPQANNLSGGVWWLRLKKAGATFTGSYSADGQTWTELSAPVENSAVASGAKAGVYTIGTNQSASKTVTFDHFHLTAPASQVKLAVSASSRCVGTSAYVAVTAVNNAGVPVTVTLTTPYGSKTVTGVAPGKQAYQSFNSRAGQIDAGAVTVKGTATIGGEQVTTSYDAAYPALGCG
>NZ_CP017717.1|WP_080040199.1|5197286_5197928_+|hypothetical-protein
MRLHRTTRTFAAAVLGVALTGLGIGVAGPASADDDPDNGIDVSVTIEPATTPGQVSMTVADNGGVSLQEDGSNATARQFVGTLPTVTVTDTRRPEEIPAGDFWAVVGQAAEFTATGGSAPPIGPQYLGWRPRLLSDTSTGAVSAGEPVSSVISDGTGAPAVGLQGQELLVSTANSADEIGTWQVNADLALRTPVDVAAGEYHSTVTLSLFNQS
>NZ_CP017717.1|WP_155127904.1|5197978_5199022_+|DUF916-domain-containing-protein
MRLETSPLTKSRALGALAALLVTLPVSLPVSLLVSLAGPAAADTTWSVVPANAGGPDGRSVIDLELAGGQQVTEHVAVTNRSTRPVDFAIDANDGYLTVKGYFDMRPSDAVPADGGAWLEVPERVTVAAGATSVVPVKVTIPQNATPGDHPAGVTASLETISGQVRVQNRVGVRLNIRVTGDYVAKVAVSDVRAEYVQSWNPFASGSVEVTYTVANAGNVRLVTDNRVLTATLAGQSDWSDPSAARARELMPGGSRTFTARVTGAWPLGPIGTTVTAIPSPAGGPLPGVAAEQVAVQATVWALPWPQLALLVLLALAYPAVRLIAAWRRKRIQKLIRLHSRETPQEA
>NZ_CP017717.1|WP_155127907.1|5199051_5199672_+|hypothetical-protein
MNKAPAYLLTLLLAGLALVLGAPAAAAHGGPIELEVTGDGADNVNVLVTYKKDGHPVTEIVEATLKATSSDGRSFGPVPLRSAPEGQNLYHAAEPLPSGEWRVTVVATEPSKAKATVKVKAGAITAAPAASAPAAAAPATPAPSQAATPPQATPAQAAPAQAAPVAAVEDRGTTGTPVKVGVIVLVALAAVGAWIGFARRHRAPVR
>NZ_CP017717.1|WP_080040202.1|5199748_5200867_+|sigma-70-family-RNA-polymerase-sigma-factor
MRGIPPSDETGADQTGAAGRLLTAARGGDGDAFRALVEPYRRELHVHCYRLLGSVQDAEDLVQETLLAAWRGIGGYEERASLRTWLYRIATNRCLNALRAGARRPAAHAMARVPPSEHAGASVPASEPVPTPMPAARPARQGEEASWLEPYPDVLLDELPDRLPGPEARYETSESVSLAFLAALQRLPARQRAVLVLRDVLGYRAAEVADLLGTTTNAVTMALKRARATLSRELPGPGRESAPLPGSPRERRLVAGFTRAFEAGDVDAIVALLTQDASLTMPPLPLAFRGPDEIRTFLATAALAGGRRYALIPTRANGQPAFGCYLRDPRTPILHAQGVLVLTLAGERVCALTRFHDNSLLTAFGLPRSLRA
>NZ_CP017717.1|WP_080040203.1|5200942_5202139_+|MFS-transporter
MTTTPTRGGTTLALATLFLGTFVLGSAELLVVGLLNLIAADLRVSVQAAGALVTAYALGVAVGGPLLTALTIRLNKRTVLTGALALCVAGNLVPVLTADHGLFVVARALTGALGGLFVAVAFVVGMSVVPPERMGRAISAVFGGFAVSGALGVPLGTLLGQVMGWRGAFLAVVALAVLALVAAPVLLPSVPGSSGGAGDQARHAFAPRVLAMLVLQFLVFASLYAALTYIVPFLERVTGVSGALVSVFLLAYGAASAAGSFAGGRFADRDAARTLTVATVMTALCLGALYLAGAVAFLVVLVLPAWGLFAMGMVPSLQYRVVRLAGPGGALASSLPASAANLGIAAGSAAGGAAIGGFTASAPVIAGLVIAVLSVPVAWGTGFLKPPAPERQPASEAA
>NZ_CP017717.1|WP_080046908.1|5202288_5203419_+|MFS-transporter
MLAALMLAALTFNTAENLPVGLLDLIAEDLQVSLSAVGLLVTGYGVTVAVTSVPVAHLMRAVPRRHVLTALLGALVVSSLVAALAPSYAVLLGARLLTALAQALFWAVMGPVAVGLFAPGVRGRVVGALSVAGSLALVLGVPAGTWLGQRTNWQVPVAALAALGLVCLVTIAVLLPTSRPEEEPAAYGSDPDVRRFRTVLAAGTLSATGAFTGYTYVVAFLGEVSGFSPGSVSVLFVVFGVACLAGVSVTGAFLDRFPQGALVAAVATQAAGLLGLYALGAHQGAAVVFLVLTGGALGPVFMTTQNAMLSCAPGRTDLALAANSGAYNVGIAAGAALGGLILPLAGVRGTFLAGGLLTVASCAVLLLTASRDRVRR

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Crispr_ID: NZ_CP017717_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_11

5494641-5494756

Orphan

Consensus_repeat	Method
CGCGGCACGGGCCGCGGCGACGGCAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP017717_11

>merge|NZ_CP017717|11|5494641-5494756|CRISPRCasFinder
CGCGGCACGGGCCGCGGCGACGGCACGCGCCCCACCTTCGGCCCCGGCACCGCCCGCGGCACGGGCCGCGGCGAAGGCACCCGCCCAGCCGCCGGCACCGCTCTCGGTGACGGCAC

>NZ_CP017717|11|9|5494641-5494756|CRISPRCasFinder
CGCGGCACGGGCCGCGGCGACGGCAC	GCGCCCCACCTTCGGC
CCCGGCACCGCCCGCGGCACGGGCCG	CGGCGAAGGCACCCGCCCAGCC
GCCGGCACCGCTCTCGGTGACGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080040426.1\|5491324_5492050_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP017717.1\|WP_080040429.1\|5496741_5499678_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274846
NZ_CP017717.1\|WP_155127994.1\|5490434_5491223_-\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NZ_CP017717.1\|WP_080040430.1\|5499816_5501397_+\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_CP017717.1\|WP_080040433.1\|5503983_5504649_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP017717.1\|WP_080046937.1\|5502929_5503994_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|239433
NZ_CP017717.1\|WP_080040431.1\|5501475_5502027_+\|acyclic-terpene-utilization-AtuA-family-protein	unknown	unknown	gnl\|CDD\|377804
NZ_CP017717.1\|WP_155129784.1\|5506696_5507578_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223674
NZ_CP017717.1\|WP_155128000.1\|5496493_5496652_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080040423.1\|5487317_5488643_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP017717.1\|WP_080040420.1\|5482367_5483426_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_CP017717.1\|WP_155127997.1\|5493779_5493929_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155129781.1\|5488705_5489551_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080046938.1\|5504648_5506397_-\|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP017717.1\|WP_080040425.1\|5489554_5490457_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080040432.1\|5502153_5502897_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225910
NZ_CP017717.1\|WP_080040427.1\|5492046_5493648_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP017717.1\|WP_155128003.1\|5507638_5509213_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NZ_CP017717.1\|WP_080040422.1\|5484475_5486908_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|185053
NZ_CP017717.1\|WP_080040421.1\|5483469_5484492_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380519

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080040426.1\|5491324_5492050_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.85242e-80
NZ_CP017717.1\|WP_080040431.1\|5501475_5502027_+\|acyclic-terpene-utilization-AtuA-family-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	7.81229e-12
NZ_CP017717.1\|WP_155127994.1\|5490434_5491223_-\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	9.01626e-09
NZ_CP017717.1\|WP_080040433.1\|5503983_5504649_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	6.50077e-96
NZ_CP017717.1\|WP_080040427.1\|5492046_5493648_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.15827e-59
NZ_CP017717.1\|WP_155129784.1\|5506696_5507578_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.37445e-91
NZ_CP017717.1\|WP_080040430.1\|5499816_5501397_+\|Na+/H+-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	1.52344e-71
NZ_CP017717.1\|WP_080040423.1\|5487317_5488643_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.85801e-59
NZ_CP017717.1\|WP_080040420.1\|5482367_5483426_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	5.22115e-34
NZ_CP017717.1\|WP_155128003.1\|5507638_5509213_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.27136e-77
NZ_CP017717.1\|WP_155129781.1\|5488705_5489551_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	8.77395e-59
NZ_CP017717.1\|WP_080046938.1\|5504648_5506397_-\|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.30119e-135
NZ_CP017717.1\|WP_080040425.1\|5489554_5490457_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.80713e-71
NZ_CP017717.1\|WP_080040432.1\|5502153_5502897_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225910	COG3375, COG3375, Uncharacterized conserved protein [Function unknown].	1.24347e-46
NZ_CP017717.1\|WP_080040429.1\|5496741_5499678_+\|AAA-family-ATPase	gnl\|CDD\|274846	TIGR03903, TOMM_kin_cyc, TOMM system kinase/cyclase fusion protein. This model represents proteins of 1350 in length, in multiple species of Burkholderia, in Acidovorax avenae subsp. citrulli AAC00-1 and Delftia acidovorans SPH-1, and in multiple copies in Sorangium cellulosum, in genomic neighborhoods that include a cyclodehydratase/docking scaffold fusion protein (TIGR03882) and a member of the thiazole/oxazole modified metabolite (TOMM) precursor family TIGR03795. It has a kinase domain in the N-terminal 300 amino acids, followed by a cyclase homology domain, followed by regions without named domain definitions. It is a probable bacteriocin-like metabolite biosynthesis protein. [Cellular processes, Toxin production and resistance].	1.40964e-18
NZ_CP017717.1\|WP_080046937.1\|5502929_5503994_+\|o-succinylbenzoate-synthase	gnl\|CDD\|239433	cd03317, NAAAR, N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NZ_CP017717.1\|WP_080040422.1\|5484475_5486908_-\|glycosyl-hydrolase	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	3.93462e-143
NZ_CP017717.1\|WP_080040421.1\|5483469_5484492_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380519	cd06296, PBP1_CatR-like, ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.17891e-96

>NZ_CP017717.1|WP_155127997.1|5493779_5493929_-|hypothetical-protein
MPHPHASRPARPVPPGARGLTGLTGLTGPGGLVGSGAAVPALPSSGSAG
>NZ_CP017717.1|WP_080040427.1|5492046_5493648_+|HAMP-domain-containing-histidine-kinase
MTARGAGRDTGRGAARGAGRAWPLRHRLLAALLGLSAAALAVFAAAGVLLLDRSLLSRVDTQLTEFATNFRKGPPPGAPVPPPRDDVELPTQFRLAIYSPSGTVVRRLPGSSSGSGDGGGDGGGGGPVVPASAIADPPPAPFTVPDGAGAGEWRTIVVRLPDGDRAAVSISLESNRSTVRQLLLIEAAAGALVLVLLGAVALAVVRLGLRPLTRMERTAAAIAAGELDRRVSDCDPRTETGRLGNALNVMLGRLSEALRQRERSERRLRRFLADASHELRTPLTSIRGFAELYRHGRSEPDPAVARILRRIEGEAERMGVLVDDLLLLARLDQERALDLTEVDPHVIAADVVHGARARDPERAVELVPPHRPVRMLADEHRLHRVLSNLVGNALAHTPPEASVRVVVRHASNPSTPSDSSAPWPLSEPVPHDSTAGGGAEAVAVAGGEVIGESVVIEVCDDGPGIEPEHLPHVFDRFYRTDAARSRAGGGTGLGLAIAAALVEAHDGRIEARSRPGHGTCFRVVLPLRGPRGA
>NZ_CP017717.1|WP_080040426.1|5491324_5492050_+|response-regulator-transcription-factor
MDAPPRLPVVLVVDDEPNIRELLLDALELNGFEVRTAASGTQALESVRREPPDIILLDVMLPDLDGFAVAQRLRPDGGGPPVLFLTARDTVADRIAGLSAGGDDYVTKPFSLEEVVLRIRAILRRTGPRADAADDDGLLRYADLELDEETHVVRRGGRRVHLSPTEFALLRYLMINAERVVSKSQILDRVWSAGFGADSRIVESYISYLRRKIDAEGAPLIHTLRGVGYSLRDHTLLDRRR
>NZ_CP017717.1|WP_155127994.1|5490434_5491223_-|aminoglycoside-phosphotransferase-family-protein
MPENEEVVLAGGGVNHVVRAGATVRRPAGPWTPAVHRLLRHLEAQGFAGAPRCHGLDERGREVLDFVPGETAGYPLPGWVRTDEALAGVARLLRGYHDATVGCSRAGEWYFPPVEPAAVICHGDVAPYNCVFRRGGPVAFIDFDTAHPGPRVWDVAYAAYRFVPLHDPGDGDGIPVGEQARRLRLFADAYGLGADDRAALVETAVKRLEHLVRFMRERAAAGDAAFAGHVARGDDRFYEMNMEHLRRSESALIFELTCRSPR
>NZ_CP017717.1|WP_080040425.1|5489554_5490457_+|carbohydrate-ABC-transporter-permease
MTTVPTRAPQSTAAAKSDPRHRRNVRRSKERPNYLAGLTSVLWLVIVVVPIYWIVITSFKSQSNYYQENPFAPPAEPTLANYRLVIESDFVQYFINSVIATIGAVVPAVAVSFMAAYAIVRGRRSRLLRWTNSLFLMGLAIPLQATIIPIYLIIIQLGLYDSLMALILPSIAFAIPLSVLVLSNFIRDVPKELFDSMRIDGATERGMLWRLAFPLTRPAVVTVTIYNSLQIWNGFLLPLVLTQSPGKRTLPLALWSFQGQYSINVPAVLASVVLTTLPILILYVVGRRQLLSGLTVGFGK
>NZ_CP017717.1|WP_155129781.1|5488705_5489551_+|ABC-transporter-permease-subunit
MTVPALVFFLGFAVIPLIGVLALSFAQWDGLGEIGVAGFANWGAILSDPGLPHALWITFLVMAVSWAVQTPASILMGAFLAGHQRYRAVLSVVFFIPLLLSSAALAITYKALLDPNFGLGAGLGIPLLVQDWLGDPVLAFGVVIFVVSWQYIPFHSLIYQGGVRQIPRSMYEAAELDGAGRVRRFFSITLPQLKYTIITSSTLMVVGSLTLFDLIFVLTAGGPGDATRVLALDMYKRGFQANLMGPASVIAVILVLVGLALSLLLRRLGGRDSGHSQLEGA
>NZ_CP017717.1|WP_080040423.1|5487317_5488643_+|extracellular-solute-binding-protein
MGVPLGAALAACGGTGPTQTGAGGGSGNATASTGGGGGKSATYWYLSTQPQEGVRTRTVERHNKANPNGTIQGTTFQNDAYKTKIKTAIGAGQAPTLIWGWGGGTLRSYVQAGQVEDLTSWFDQNQAVKDKLFPSSFGAATIDGKIYAMPCETLQPIVLYYDKRAFDKIGAQPPQTWGDILDLVPKFNAKGIAPFSLGGQSRWTNMMWLEFLFDRLGGPEIFQAVFDGEKDAWNNPLAIQALGEVQKLVKANGFVKGFSSITADSNADQALLYTGKAAMMLHGGWTYGSMSTDGGDFVSGGNLGYMNFPPIDGGKGDPGNTVGNPGQYISISSKATPEQKEIAKKFFAGALIDQTAVKEWVGTGAVPIIKGADAEFAASKDKDFLTFVYNIAVNAKSFAQSWDQALSPTAAEVLLDNISKLFQLSISPQEFATNMNAVIGK
>NZ_CP017717.1|WP_080040422.1|5484475_5486908_-|glycosyl-hydrolase
MTALDRTPTAERAVRPWQDPALAVADRVEALLAEMTLEEKIGQLGSRWLGNDMSSGDEPEPEPGAEPLNVAPMQDVFAASGTVPLEEAVRHGLGHLTRVHGSAPVTPAQGAAEVVRQQHAVVAASRLGIPAIVHEECLTGFTAYGATVYPAAIAWAATFDPGLVERMAAAIGRDMRAVGVHQGLSPVLDVVRDYRWGRVEETMGEDPYVVATLGAAYVRGLESAGVIATLKHFAGYSASRAARNHGPVPMGRRELMDMILPPFETAIALGGARSVMNSYADVDGVPAGADPWLLTEVLREEWGFTGTVVSDYWAVPFLASMHLVAADHEEAGVLALGAGIDVELPDTLGFGQHLAERVRRGELPEAVVDRAVRRLLTQKAQLGLLDPGWTPEGSVAGAESVDLDSPANRALARELAERSIILLDAGTALPLLEEHGGTAPRRVALVGPAAHDPRTFMGCYAFPNHVLPRHPGLGLGIEAPTVLDALTAELPQSEIRYAKGCDVRGDDRSGFADAVAAARDADVCVAVVGDLAGLFGHGTSGEGCDAEDLRLPGVQADLLAELAATGTPLVVVVVSGRPYALGEIHEHAAALVQAFMPGEEGGAAIAGVLSGRVQPVGRLPVQIPRHPGGQPGTYLQPPLGTDSHGISNLDPTPLFPFGYGASYTTFEVTGLRLSAEEVPTDGEFTATVTVRNTGGRAGEEVVQLYLHDLLAQVTRPVRQLTGYARVRLEPGESAEVAFLVHADRTAFTGRDLRRVVEPGDVEVLAGTSAADLPCRGVVRLTGPARHVGHDRRLVTPAEVRGRGGADAIQS
>NZ_CP017717.1|WP_080040421.1|5483469_5484492_-|LacI-family-DNA-binding-transcriptional-regulator
MPSSPRRATLATVAASAGVSVATVSKVLNGRSDVSPATRSLVQSLLQQHDYVAPAPRREPPGLATVELQFDADLNAYSTEIIQGAVAAGAEAGIGIVVSIRSGTARTTAWARQLVAAGRRALIAVTGELTSGQPAALARARLPLVLIDPLNLPRTRVTSIGSTNFAGGLSATQHLLSLGHRRIAYIGGPPAAACNQARLHGYRAAMEAEGAPVLPGYVRSGHFRYHDGMASGAAVLDLPHAPTAIFAGCDEVAVGVMEAARARGLRIPEDLSIVGFDDTQIAQLTSPPLTTVRQPLREMGGVALRTALRLAAGEKVDSHHVELATELVVRGSTAPVPDRG
>NZ_CP017717.1|WP_080040420.1|5482367_5483426_-|NAD(P)/FAD-dependent-oxidoreductase
MELSEAVVIGAGQAGLSSAYFLRRYGIEPVVLDAGHGPGGAWRHRSPTLTMEKVHGVFDLPGLGRQEAGGEPGRPAAEVVPAYYASYESATGLRVVRPVRVTAVREGARGRLAVETDAGEWQARAVVNATGTWTRPYWPYYPGAAGFRGRQLHYAAYRGPREFAGRRVVVVGGGASAMHVLSELAGVAAATVWVTRRPPVFRDDDFGTEARRAAVAMVESRVRAGLPPQSVVSVTGLTYSTVVREAMDKGALHRLPMFGRVTEDGVAWDDGTRVPADVIIWATGFRAALDHLAPLRLREPGGGIRVDGTQVVKEPRLQLVGYGPSASTIGANRAGREAARNVRALLSGRLAA
>NZ_CP017717.1|WP_155128000.1|5496493_5496652_-|hypothetical-protein
MRFIVDLEYGTDGVHGLVTREGCDRSEPFHGWLELLSVLESPRSRGNPWDGP
>NZ_CP017717.1|WP_080040429.1|5496741_5499678_+|AAA-family-ATPase
MDRHVSTGGLDTAREPGIPRMRRVVMAEAIAMFVGRDAELRCLREEFERARAGLPRLVVVEGPAGIGKTTLVHRFLEGCGPADVLFTDGDEGEKLLPYGTLTRLFGGPAGLPERLTELGLGLGSGPDGQSRLPDSLAVRAALPDPLAVGAALPDAPPFRAALPDPLAVGAALLDVVTERQRSEPLCLVVDDVHWADEPTLRALTFCLRRLRVDRVLAVLMLRDAAALAGPEGLLRLVAADHTRRLRLSGLGAPEVGAMVGELGGAPVSQRGLARLVEHTEGVPLHLRALLEEVPAAALDDLGQPLPAPRSYGLLVLGKVARCGPAARELISAVSVLGLSCPLHLAARVAAVEEPLQALEQAVREGVLLERSSARGPLAAFAHPLDRAAVYRDLGPAHRSALHARAALVAEGEQARLRHRIEAVAGPSPELAAELAELGRTQVRLGAFGSAAEHLKAAAELSGDPAPLAAEAVEALLLDGRVEEAARLTASLPERAHAAVRGYALGHLAMVRGQIEEARAHLVTAWERAGAPESGLAARAAQQLAMLCLVKAEGRQAARWAERARNSPGYRFSIDYNRYTLLAGLGVSGQIDAALAATTDLPAPSSASIAELDALLGRGVLRTCSDDLPGGLADLSGAVAACGERSVPFRMLAMAMLGQAEYRAGRWDDAGLHAETAASVADDADQRWLSPVCHAVAALVPAARGDWPAAEAHVAAALSASQGAGVDAVASLAYACSAAAHLATARGDHVRTVEALEPLVSVKVHDIVYEPGIVQWLDLLIDALVALGEQDRAELQLAGMERLAGRRGRRSAMAAAARCRGGLHAARHENDLAEAAFTTGLAQAGMAGLPFDEARLRLAYGRFLRRLGRRRQAQTQLDLGLALFARLGALPYVDRCERELSACGLPRAESGAAPLLRLTPQEQAVARLVATGMTNRQVARELVLSVKTIEYHLGNAFAKLGVSSRVALTTKIQSGADGG
>NZ_CP017717.1|WP_080040430.1|5499816_5501397_+|Na+/H+-antiporter
MDQFVLLMLVGLGALVTVPLGERLGLPPPVLMTLLGILLAVLPFVPDVDVPPGIVLPLLLPPLLYAAVQRTSWRQFAANWQPIFLLAVALVFVTTAAVAGAAHVLVPGLPLAAAVALGALVAPPDPVAATAVAGRLGLPRRMVSLLEGEGLFNDVTAIVLYHVAIAAVVTGSFSWPGALAEFVLSAVVAVLVGLALGWLGGRLMALLGDATLQVGLSLLVPFAAYALADEWRGSGVLAVLTSAFYLSDRMADADDVFGRFASTTFWQVVDTLVTGVAFGLIGLELHAVFGTVHGRLVTVLGWSAAVVAVVVLVRLLWLLPAAWLARKVGRGGDTEVPLSWRETVVMWWAGMRGVASVALALAIPLQADDGTPFPQRAVIVFVAFAVILTTLIAQGLTLPWLVTRLGVKADTAAERELEKRLALRAAKAAKRRLREIDEAEELPEDVVEVLNRRMLDLGLRISPEVADEERREAFEQRARRVRLMRRVQAEMMSAARQAVLEARRDPSADPVVVSRVLRQLDARSLR
>NZ_CP017717.1|WP_080040431.1|5501475_5502027_+|acyclic-terpene-utilization-AtuA-family-protein
MLRIGTWRSPASVDVIACGWHDDGPGPLGTGIKLIYDMSGPAPHLPGLKVGALVARSTEEIAELLVQGMDVVLTAPGGCPAAPVVAAGIWHYGWTRHDRGALAGATVAGLALAAQPGPCVVEIWRDGRSSLDGDVTAAAVRADLADRFAGGRYRTPEVTVPLESVRLSQVAPSRVRIALAAAI
>NZ_CP017717.1|WP_080040432.1|5502153_5502897_+|GNAT-family-N-acetyltransferase
MVEVRELHEMAELERVDALFDDIWQFGPGAPPITIELMRALSHAGGYVAGAFDGERLVGASVGFLAAGRALHSHVTGATLRGAGLELKLHQRRWALERGLERITWTYDPLVRRNAHFNLAKLGARPVEYLPCFYGVLDDAINQGDETDRLLASWPLAAPPVRADRPVPDDVVVALADEGGRPVTASVAGARTVLVAVPEDVEGLRRADPGAGKAWRHAVREVLGGLMAEGHAVTGFSGKRYYVVERA
>NZ_CP017717.1|WP_080046937.1|5502929_5503994_+|o-succinylbenzoate-synthase
MPLVAPFRTSFGTETARDVLLVRVVTPDAEGWGECVAMSEPLYSSEYVDGAAEVIRRFLLPALPKNVGAYDVGRALEPIKGHRMAKAALETAVLDAQLRASGESFAHFLGAARTRVPCGVSVGIMDSVPQLLDAVAGYLDEGYVRIKLKIEPGWDVEPVRAVRERFGDDVLLQVDANAAYSLTDAPRLAKLDAFDLLLIEQPLANDDLVQHAKLAQRIRTPICLDESIESAEHAAAAIALGSCSIVNIKPGRIGGYLEARRIHDLCRANGVAVWCGGMLETGLGRAANVALAALPGFTLPGDTSGSRRYFATDVTEPFELVDGHLEVPAGPGLGVEPIPAVLDEVTTATEWITL
>NZ_CP017717.1|WP_080040433.1|5503983_5504649_-|ABC-transporter-ATP-binding-protein
MIIRNLSVRYGRFTAVDDVTLEIPDGRIVGLVGESGSGKSSLARAVCGLVPHTGTVEGARRTQMVFQDPYASLNPRMTVARTIAEGAGPGEVERLLGLVRLPAELAGRYPRELSGGQRQRVAIARALGGDPGLLVADEITSALDVSVQAAVLNLIRGLRDELGLTMLFISHNLAVVRYVADVVAVMHRGRLVEAGPAEQVVGEPAHEYTRALLAAVPRLRG
>NZ_CP017717.1|WP_080046938.1|5504648_5506397_-|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein
MVVLAVVGPLVWGEAAGRIDAAAILQGASPEHPLGTDNLGRDLLARVLVAGRYSLLLALAATLVGAVAGVVLGTLPSVLPRRAARLVTATVNALVAFPGLLLAMFTAVVTGLGARGAVLGIGAAIAPGFARLTQTLAARVAGADYVAAARMLGVPRRRILTRHVLPNIAEPLILNLAQAFGGALLGLAGMSFLGLGVQPPQYDWGRLLFDGFPRIYVTPEVALGPAAAIALAGIGFNLLGDALARAAARTSATGAPAPAPAAAPPGEPDPGAVLEVRDLTVAFPGGLTPVREVSLSVAPGEIVGLVGESGSGKSLTAAAIGGLVPYPGTVTYGALRLGGRDVATLSDRELGTALAMVFQDPLAALNPALKVGGQLAEVAVVHEGASRAEARRRAVDRLGHVHLPEPERLAGRHPHELSGGMRQRAVIAMGLMGTPRLIVADEPTTALDVTVQRQILRLLREVVDETGAATLFISHDIAVVGELCDRVVVMYAGRVVEELPAGRLAGGAAHPYTKALIASLPDLDTDRERPLAGIPGAQPGPADVGPGCAFAPRCALATARCESDRPELAARGAGQRVACWEA
>NZ_CP017717.1|WP_155129784.1|5506696_5507578_-|ABC-transporter-permease-subunit
MVASFAMVHLIPGDPVRTSLGPAAPVELVAARRAALGLDRPLPEQLFTYATHVLSGNFGTSFLTGEPVGDVILTRLPNTLALALLATALALLVAVPLGMWTAVRTENGRNRGTDLAFSAATGAAVALPEFLYAIGLVAVLAIGLGWFPPAGMAGPATYVLPVVALAIGPAAMIARITRVETLRELGKDYVRLARAKRLPAGRLHLRHVLPNTLTATLTVGGLLLTSLIAGGVLVEYVFAWPGLGLKIVESITQKDYPVAQGVILVYGAIVLVVNLAVDLALGALDPTSAIKEA
>NZ_CP017717.1|WP_155128003.1|5507638_5509213_-|ABC-transporter-substrate-binding-protein
MRTPRAAALTALALLAAACGGTGGGGAAPTGGGTFTYALPSDPGVLDPATGVLGVTITTLSLAYDTLTGVTADGKVVPGLAEKWAVEPDRVTFTLRKDATCSDGARVTPSDVAASVNHIADPATKSPIYGVLMPTGMKATADDAAGTVTLSMPKPFSFILESTRLIFVVCGKGLKDRSLLARGTSGSGPYKLTEAVPGDHYTFKVRREYAWGRPGSTIKDAPETVVLKVVPNEQTAANLLISGTINGATLYGPDRARLEATPGIGKKAVSEANGEFFYHQGEDRPTADPAVRKALTQAVDLKELAGIASGGTGKTPTGLVLPPRPCQGDTVTGHVPAHDPAAAAAALDAAGWRAGPDGVRVKDGERLTLRYLYATTRGAGTQAAAEYLAAAWRKAGAEVKLNGVIDTKLSESLNATQDWDVVWLPIGVPLPSQLVGFLSGPAAPKGANFAHLSNDRYEKLVAEASLKPAAEGCAQWLEAESALFESADLVPVTETTVLQAAKGATYEQVGGLFVATSIRLGQGG

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Crispr_ID: NZ_CP017717_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_12

5924273-5924345

Orphan

Consensus_repeat	Method
TCACGGCGCCTCCTCCACCATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_12

>merge|NZ_CP017717|12|5924273-5924345|CRISPRCasFinder
TCACGGCGCCTCCTCCACCATCACGCCGGCTTCACGCGGGTAGTCCCGGTTCACGGCGCCTCCTCCACGATCA

>NZ_CP017717|12|10|5924273-5924345|CRISPRCasFinder
TCACGGCGCCTCCTCCACCATCA	CGCCGGCTTCACGCGGGTAGTCCCGGT
TCACGGCGCCTCCTCCACGATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080040746.1\|5918092_5918974_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP017717.1\|WP_080040748.1\|5918966_5919707_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|272861
NZ_CP017717.1\|WP_080040782.1\|5929822_5930479_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_155128091.1\|5937073_5938738_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_CP017717.1\|WP_155128087.1\|5933449_5935504_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046982.1\|5923619_5924261_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP017717.1\|WP_080040788.1\|5938724_5939756_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|340411
NZ_CP017717.1\|WP_080040784.1\|5931439_5931877_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP017717.1\|WP_080040751.1\|5921171_5922707_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236215
NZ_CP017717.1\|WP_080040741.1\|5914798_5915749_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239481
NZ_CP017717.1\|WP_080040750.1\|5919788_5921018_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP017717.1\|WP_080040752.1\|5922782_5923610_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270315
NZ_CP017717.1\|WP_080040745.1\|5917155_5917776_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080040756.1\|5925724_5928085_-\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NZ_CP017717.1\|WP_080046981.1\|5917790_5918096_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|316153
NZ_CP017717.1\|WP_080040785.1\|5931974_5933336_+\|phenylacetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|224458
NZ_CP017717.1\|WP_080040787.1\|5935508_5937077_-\|fused-response-regulator/phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP017717.1\|WP_080040783.1\|5930609_5931443_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155128084.1\|5928260_5929826_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080040743.1\|5915745_5917098_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080040746.1\|5918092_5918974_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.47383e-84
NZ_CP017717.1\|WP_080040748.1\|5918966_5919707_+\|ABC-transporter	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	0.000728614
NZ_CP017717.1\|WP_080040782.1\|5929822_5930479_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.10445e-76
NZ_CP017717.1\|WP_080046982.1\|5923619_5924261_-\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	8.47584e-97
NZ_CP017717.1\|WP_080040788.1\|5938724_5939756_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	2.48951e-26
NZ_CP017717.1\|WP_080040751.1\|5921171_5922707_-\|AMP-binding-protein	gnl\|CDD\|236215	PRK08276, PRK08276, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP017717.1\|WP_080040741.1\|5914798_5915749_+\|hypothetical-protein	gnl\|CDD\|239481	cd03386, PAP2_Aur1_like, PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.	8.73055e-12
NZ_CP017717.1\|WP_080040750.1\|5919788_5921018_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.59477e-95
NZ_CP017717.1\|WP_080040752.1\|5922782_5923610_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270315	cd13597, PBP2_lipoprotein_Tp32, The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold. This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	4.37516e-120
NZ_CP017717.1\|WP_080040784.1\|5931439_5931877_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.00427706
NZ_CP017717.1\|WP_080040756.1\|5925724_5928085_-\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP017717.1\|WP_080046981.1\|5917790_5918096_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	1.57245e-21
NZ_CP017717.1\|WP_080040785.1\|5931974_5933336_+\|phenylacetate--CoA-ligase-family-protein	gnl\|CDD\|224458	COG1541, PaaK, Coenzyme F390 synthetase [Coenzyme metabolism].	4.37327e-52
NZ_CP017717.1\|WP_080040787.1\|5935508_5937077_-\|fused-response-regulator/phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	3.08081e-35
NZ_CP017717.1\|WP_155128091.1\|5937073_5938738_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.53986e-57
NZ_CP017717.1\|WP_155128084.1\|5928260_5929826_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.36375e-40
NZ_CP017717.1\|WP_080040743.1\|5915745_5917098_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.56043e-53

>NZ_CP017717.1|WP_080046982.1|5923619_5924261_-|ABC-transporter-permease
MLPLLWPATVETAQMVGWSTLFTVLLGLPLGVALVVFDRDGLRPLPAFKSGLGFVVNVGRSLPFIVLMIAIIPFTRLVVGTTIGTAAFVVPLTVGAVPFFARLVETALREVGTDVVQAAQAMGASRTAIVRKVLLPEALPGLVAGLTVTVVALIGYSAMAGTLGGGGLGDLAVRYGYQRFETLLMIVTVVLLLVIVQLLQSLGDWVARRLSHK
>NZ_CP017717.1|WP_080040752.1|5922782_5923610_-|ABC-transporter-substrate-binding-protein
MKIHRFVGAVALALSLAACGTSQSATGTPAAEGADTVVKVGASPVPHAEILNFVKDNLAPAAGIKLEVVEFTDYVQPNVQLDEGQLTANFFQHKPYLDDFNATKGTKLSFVTPVHLEPLGLYSKKITNVSALASGATVAVPNDATNLGRALKLLADNGLITLKDGAGTAATERDVTGNPKKLQFKPLEAAQLPRSLEDVDAAVINGNYAIEAGLKPASQALVLEKTAGNPYVNGLVVQAGHEKDPNIVTLGKLLQDQKVKDFIKQKYEGSVIPAE
>NZ_CP017717.1|WP_080040751.1|5921171_5922707_-|AMP-binding-protein
MHPGAIAAVTPGKPAVIMAGSGRIITFRELDEESNRLAHLFRAAGLRPGDHIAFMLANHPQFLAIAWAAHRSGLYYTPISSRLQTDELAYIVGNCGARVFISSADLAAVATSITAGTPGVELRLMLDGVAPGFASYEEAVAGQPVTPIADECQGADMLYSSGTTGRPKGVKLAASHGPLDEPGLLFKLIQGLFAPTPGSVYLSPAPLYHAAPLRYSMTFQRLGATVVVMERFDPERYLELVERYGVTHTQLVPTMFIKMLKLPEETRAKYDISSLRYAIHAAAPCPVPVKEQMIGWWGPIIHEYYAGTEGNGFLYVGPEDWLRHKGTVGRSLLGTVHICDENGDDLPPGEHGTIYFENGGRFEYHGDPGKTRSSQDPLGRGWTTLGDIGYLDEDGFLYLTDRRSYMIISGGVNIYPQEAENVLSVHPKVADVAVFGVPDEEMGEQVKAVVAPASMDEAGPALEAELIAYCREHLAHYKCPKSVDFRAQLPRHPTGKLYKRLLRDEYWPASK
>NZ_CP017717.1|WP_080040750.1|5919788_5921018_-|PDZ-domain-containing-protein
MNANEPREQGTGGWSQFGATPPAAGGFPRRDTIAMEVPPPPPPPPSDKHRLTVAQKAIAGLALAAMAVGGGVVGAAVATSFQPEPVAGSSPSAPSPVFKSASEQLTVAEVAAKVQPSVVMIQGQSGEGSGVVLSEDGLILTNNHVVVGAGQGGQMTVKFSDGKTAKATVVGTDPATDLGVIRAEGVSGLTKATLGDSDQLKVGDPVLAIGSPLGLEGSVTAGIVSALDRTLNLGDDQPQVPPGWGQQQQQSAPTTIGGAIQTDASINPGNSGGALVNAAGQLIGINTAIASQAQGGGVGFAIPVNTAKQVADQLISTGKVTHAFLGVSVTDATGDVPGALIRQVTAGSPAEQAGLKEGDLITKIGDKTVDGGDTVVGQVRGFKPGQEVKITYMRDGTTREVTVTLSENK
>NZ_CP017717.1|WP_080040748.1|5918966_5919707_+|ABC-transporter
MAELIAAHARLFLLEQLRVPVGLLASALFPAISFVAFVVPFAGDDPRAATMAAASMIFFGAMAGALINLSITVAQDREQPWNPYLRTLPAGPLPRFSGRILATLAGTLVSVVPVLLLAMLLTEATTTLPRLLLGLGALLAGVVPFMLMGLLIGLVMAAKAAIAVSQVLFFPMAIVGGLLLPPRMLPGFVEVVSPYVPTRGVAELLWAITAGTTPDAVALVSLAGWTVVVAVAAAWAYRRDEGRRFS
>NZ_CP017717.1|WP_080040746.1|5918092_5918974_+|ABC-transporter-ATP-binding-protein
MTILTRAIEVSRRYGDVLALDRVSLDIRAGELVGLLGPNGAGKSTLINLFAGLRRPTSGVVELFGGSPQDPAVRRGIGVTPQETGLPEALRVGEIVDFVSAHFPDRADKGELLARFGLDDLVRRQVGGLSGGQRRRLAVALAFAGKPQLVFLDEPTTGLDVEARRSLWEGVRSFHRDGGTVLLTSHYLEEIEALAERVVVVGSGRVLADGTVRDVRDVVGVRRVSLVAPDLPELPGVVGSERVDGRVDLLTTDPDRLVVELVRSGTPFSGLEIRPTTLEEAFLALTSKEPSHG
>NZ_CP017717.1|WP_080046981.1|5917790_5918096_+|helix-turn-helix-domain-containing-protein
MPELDPVIHAQARLRVVAALNVLGDGDEMAFNALRKLLGMTAGNLSVHLTKLEDADYVRINKTHRGRTPVTFVALTTRGRLAFEDYTKAIRTLLDNAGGAT
>NZ_CP017717.1|WP_080040745.1|5917155_5917776_+|hypothetical-protein
MVDDERTPSPEEMLRVIEEQSVATTRWLRGDPLFLYAPWGVAWMLGFTALFLHYGLDGRSYAPISQMQAVGVLMAGQLVAGAFVAYGIVRMNKTTRGDSNARGAMFGYAWFAGFALMVVICSRMSPLLPPQESGLLWAGSSLMLVATLYMAGGALFHNWTFFFFGVWVAAVNTLGVLLGAGWHALLTAVLLGGGYIVAGVLVRRRS
>NZ_CP017717.1|WP_080040743.1|5915745_5917098_+|cytochrome-P450
MNPGGPVPRRPAASAWEPWLGSGALLAALSSDDRLVERMFERTGGMFRLWLPGAGKAVMLADPALVRDVCRAPADVIDAARANRVQEPVIGRQGLACLDGQEHRRLRQAMAPAVREQVSLRLRATTERLARRVADDCPIGVPFALEPRLHLALMEAILSITLGLGPAAQRAWEGPLRELFRRAASYEISVRYLLRQVGGLALWPSFHRSRNACDRLIHDEIARRRHPIEPDQADGGGDDLLGMLLRARGDDGARLTDEVIRDQVMSMIAGARTTTATGLTWAFERLVRHPEVMSRLVAESDKGAGDAYAGAVVYEALRVRPPVAFFGRVVRRPFELGGRVLSPGTTIVVHLRCLHHSPGLHPEPAAFRPERWLERRPGGYGWMPFGAGTHTCLGDQLAIMQMKVFLQVFARTLDLSPARAADEPVRLMAISNTPGEGCRVVARRRAATAG
>NZ_CP017717.1|WP_080040741.1|5914798_5915749_+|hypothetical-protein
MLLSTSRDRGREKMRQLRPVELLVLSYFGISAVLHVTLGDPARDGPMAVVTCVLPAALLLALIRLELRFRGRFRLSALRFAYPLLMLTPMYSSAARTVLYLHGHYVDEAVNAWEKSAFGVFPNVAMGAVHSPLLTEIVTICYFSYYGSFLIPFFLYARGRKPLAERYMFAALLVLLTCYLSFMFVPLAGPAAALPREFLAGRPDGYLVTDLQNAIMAAFDPPGTCFPSPHVAGAWITLLTLRRHVPELVRYALWAATAGLTVAVVYDWYHYASDALAGFLVALAVHAVTRRGTAFRPPPERPVPDRPAPLTVAAHP
>NZ_CP017717.1|WP_080040756.1|5925724_5928085_-|endopeptidase-La
MSESLTLPVLPLDDAVVLPGMVVPLDLSDSEVRAAIDAARASGGNKPRVLLVPRIDGRYGAIGVQAVVEQVGRLPGGEPAAVVRGVNRVRVGTGTTGPGAALWVEAETIDTVAAGERAQELAKEYKALATTILQKRGAWQVVDQVNTIDDPSVLADSSGYTPWLSTAQKVELLEEADPAERLAKLIEWSREHLAELDVAETIRKDVQEGMEKQQREFLLRQQLAAVRKELKELNGDSTESEEEDYRARVEAADLPEKVREAALKEVDKLERTPDQSPETGWIRTWLDTVLDIPWNERTEDNYDITGARAVLDADHTGLDDVKDRIIEHLAVRKRRQDKGLGVVGGRRSGAVLALAGPPGVGKTSLGESVARAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIREAGSMNPVVLLDEVDKVGADYRGDPTAALLEVLDPAQNHTFRDHYLEVELDLSDVLFLATANVLEAIPGPLLDRMEVVTLDGYTEDEKVAIARDHLLPRQLELAGLTAEEVTVEDAALRKLAGEYTREAGVRSLERSVARILRKVAAKDELPVTVGEDDLVGYIGRPRFVPESSLPEAKQRTSVPGVATGLAVTGAGGDVLYVEASLADPETGETGLTLTGQLGDVMKESARIALSYLRSHGAELELPVTALKDRSVHVHFPAGAVPKDGPSAGVTLTTALASLLSGRLVRSDVAMTGEISLTGRVLPIGGVKQKLLAAHRAGITTVLIPARNEPDLDDVPQEVRDELTIHTVSDVREVLDIALTPAKVATTVAA
>NZ_CP017717.1|WP_155128084.1|5928260_5929826_+|sensor-histidine-kinase
MILVQRARSLGRSLARRRPWKSARKGAQEGVPEEAHKGAGESAQETARETTGQEASPETGQEASREGAREGARKLSRERALQRARDRVWDTGRTLGRPFALALFEGDADPPAARRLTFKVPRRLRALVPFTSYSAVQAADLLLAFILYGMMLSESLDWNHAAGRAHAANPAIPGPVPEIFLYLSTIGVSLPVALRDRWPLAAWRIAAVLSPLVVWVTATVGRTEPPYPVMGIVMYLLVLYSVAVRCERRITMAVWVLTVLALWIVHPDSMFLASIIASVAVLFGYNVRARRTATSRLAEEERRSRQAEGAQAVLEERARIARELHDVVAHHMSVIAIQAEAVPLKAAGDAAQLEAGLAEIRGLSLEAIAQLRQVLGVLRDPQGRTDTAPQPGLDRIDELVSNARAAGLAVVVKRSGSLGGQSQAVELSAYRIVQESLSNVMRHAPGATVAVEITRRGDELRLRVANGPGTGPREASGGAGQGLVGMRERAALLGGTLEAGPTGGGGFEVRATLPITERESA
>NZ_CP017717.1|WP_080040782.1|5929822_5930479_+|response-regulator-transcription-factor
MIRVLIADDQGMVRTGFTVFLSGQPDIEVVGEAADGREAVERAAELSPDVVLMDVRMPVMNGLEATRELMARQGTAKVLILTTFDLDDYVYEALRAGASGFLLKDASAAQLAEAVRVVAAGEALIAPAITKRLITEFARMGAPRPVTGRRLDELTERETEVLSLVAQALSNQEIAEKLYVAEQTVKTHVGRVLMKLGLRDRAQAIVFAYETGLVRPGE
>NZ_CP017717.1|WP_080040783.1|5930609_5931443_-|hypothetical-protein
MSENPSGPSAPARTAATIDPIALSTFLLTSSATVIIYVGWVYTDSYLELFQLDASAIGYRLDEYALRGLNLFRPEVLPWLVVLPLVVLAAGLRCDVALRRRLLGGAGSGATALGLLLAAVALAGGSVNTILILLLIAGGLPLLVALFRERPLGRVAFIMAAGVAILCLLWSAALFAQLRGAEAARAFAESLPRRTQVSIFAKDQLALNAVGVTRTDLPKGMYRYRYDGLRLLLSRESRHYLVPAMTYEQWRRGLGRVVLLSESESVRIELLPGVRSG
>NZ_CP017717.1|WP_080040784.1|5931439_5931877_-|hypothetical-protein
MNIDHRTAGAAAALGLAAVLALGACGSAPSGPAGDPVSSSIGQGAEGPRASGSATVKKKRPKKSSAACPAGGGDVVAAACPSLDTGHSPGGRFTGPPTASEDPETGLTGPLAPTETPEPPTPEPGQKQLPTPEPEEQPTPEPGDT
>NZ_CP017717.1|WP_080040785.1|5931974_5933336_+|phenylacetate--CoA-ligase-family-protein
MDPVELFHQVAATVPAYGRFLAEHRVDPAQVVTFEDFTRLPMTTKDTYTRRHPLPDLCRNGVIGDMIAVSSGSTGVPSFWPRSAADERVIADRFEEVLGGSFGARERRTLAVVCFALGTWVGGLFTVACCRHLAERGLPITVVAPGTDRREIARVLPELAPYFEQVVLLGYPPFLKNVVDTEDLPWASWDVKLVTAGEVFSEEWRTLVAERAGIADPVRGIASLYGTADAGVLGNETPLSVELRRFLSARPGTARELFGESRLPTLVQYDPEVRFFEEHEGTLLFSGDNGVPLVRYHIADEGGVIPYEELLGFVRRHGFEPREDGPRRPFVYVFGRSHFTVSYYGANIYPENIAIGLEQPGVSERVTGKFVLEAAEDERRDRHLTVTVELMPGERPSEETAQAVGASILAQLLRLNSEFAAYVPVPRQAPFVRLREAGDPEYFPPGAKHRYTR
>NZ_CP017717.1|WP_155128087.1|5933449_5935504_+|hypothetical-protein
MLDDLGRMFSWLMAALVRPVSGLYGEFDLRPGDRDPGPGLPARYGGADRPGVTGTTHVRDLHRDLRELGFLLAPEDTAEFTTATWLAVMEFQRYASLSDAATEREPRAATLLDEVPPDASLLHVSAASAFPPQGPFRVLAGEEIMEVTAVTTARTTGTDAALKVTRGMEGTAAAAHARGAEVELIRWSDRLVPAHAPFYERYADPVTGVVNAWTRFVLRRWKEGRRRCPIVVEAWELREGRPDRLHTIPAAEGRPARRAGNVWGAREVTATGPRLYVRDLTSTWRRPSRPPIVPERPELDVTGDYRVLGDYAGPRAWPEFGHTWRPEGEMLPEHLLPATEPGGSGPTLGQLIEAGDAAALGTYKVVRAVSEVEAIGYFDCMNAYDRAFVSLGPCHWTAGLATGPSPASAVDEGELWGFMAYLKATDRYAFAQAVGRFGVDVGTEWGQDGAALFEPGQRKYTGRPALPREGGGRYELGKVEEYDLFRGWHWFYRLQMAGRTVDGFRRAMWDMARLRLRDVGETPWDGPAEPPTWTVPGPDGPRPARIKDVITSERGMAIVYRWHIRAPANMVSAGPASEPPETRRIGRAGPVLRAACEAAIREEPGLFTGSPDTWGDAAEQALVARLRAQGGASVEYVHEWPRQVSASRGFALPYELLPDHGDGRRLDPARGSFHLDTRGLPPPP
>NZ_CP017717.1|WP_080040787.1|5935508_5937077_-|fused-response-regulator/phosphatase
MSETATVLVVDDTPTKRYILSSWLRRAGHEVVEAGGGEEALATLAARHVDLVILDVRLPDIPGHVVCERIKANPATASIPVIQVSANAITVADRAEGLERGADAYLAEPIEPAEFSATVEAMLRYYRARWRAERMAERLAGLADVTLRMNEADTFDALLSVAVEGAAGVLGRFCGTLVLLPDGRTRRYRARPGERATPHPAGPDLLHRLSGMVQRETQRAHVFTLDARQWRDLLPDIRFDGDTTGVLCRTKNSGAPVYLGVESDPPLDADEVNLLRQLGQQLALAVGALRAYTEEHAIALTLQRSLLPTRIPQVPGLRVAMRYEPAADNIEVGGDFYEVLPIGERVLVAIGDVEGHSLHAATVMAELRHAMRASFIGQADLSASLDLLNQMMRRYHPRMTATLCLMLIDPATGEVEIGNAGHIPPLFAGPGGTYHNLGNLLLGALPETYTVDRLKLPPGGTLLLFTDGLVEDRRISLDESLEKARKLAEVVEDDLEDFADRILSAFGVREDDVALVAVRREP
>NZ_CP017717.1|WP_155128091.1|5937073_5938738_-|response-regulator
MDKAEAAELVRVRLDADQDVFVLRGIGRAAAELAGLEPQDQIRVATALSEAGRELFGDGSSAVLMLGDRHLLIRLEHSKRSDVSALDGLRLAGRLVDEITVGEGSVTLAKRLRPRRTSASVAEIRAKLAALSPVSALDELREQNRELAETLEDVRRLNAELQETNTGVMAMYNQLSTELEETNRGVVALYAELDEKSSRLREAQEARNRFWATVSHELRTPLNSVIGLVRLLIGPGGDPMTEEQAHQVRLIGTSTETLLELVSELLDMAKAESGRLDPQPSAVDLVRMADQLHVMLRPTSASTGVELRHEVAPEVAELYVDEGMLLRILRNLLSNAVKFTLSGEVRLEARLDEAKDEAVITVTDTGIGIPQEHLTRVFEDFYQVPGSLQVRSRGTGIGLPYARRLAETLGGTLELTSTEGEGTTATLRLPHYSGPPELERVLIADDDEVFRATARRMLHGFAAHVDEAADGAAALEAMAAERPDAILVDLLMPRVDGNVLLQRMAEDDRLRDIPVVVVTIAPQRAPDDMVVLDKHGLRRDDLLQAVRRARGERA
>NZ_CP017717.1|WP_080040788.1|5938724_5939756_-|SpoIIE-family-protein-phosphatase
MVPVTTWVRAEDPSAVGAVRRKAVELAEAAGFDQVLIGQTAVAVSEAVSNLVKHAMEGTVIVRPHPESAATVELITVDRGPGMADVARALRDGYSTSGTLGIGLGAISRIATGYDVHSLPGKGTVLAMHFTGRPPAPPLRASGLTRPIGEETVCGDGFVIAQSGPVTTVLVSDGLGHGLIAAQATQRAAELFRAVRDLEPAEIVARLHAGMKATRGGAVAVARVEPGQVSYAGLGNVSGWITHAEGRQGMVSVPGIAGHQGGRLRQYTYDLPSYATVVLHTDGLTERWDPSLLPGLFSRTPAVIAAGLMREAGSRRDDACVVTVRPDRQRDRAGGEPKSDGQG

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Crispr_ID: NZ_CP017717_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_13

6391044-6391163

Orphan

Consensus_repeat	Method
CACGTGCGGCGCAGCACAGGCCCACGCAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_13

>merge|NZ_CP017717|13|6391044-6391163|CRISPRCasFinder
CACGTGCGGCGCAGCACAGGCCCACGCAGGCGACCACCGTGATGCGAGCGATCCGCAGGGCGAGAGTGACGGGCGGGAGTGGCGGGCGCACGTGGCGGCGCAGCACAGGCCCACGCAGGC

>NZ_CP017717|13|11|6391044-6391163|CRISPRCasFinder
CACGTGCGGCGCAGCACAGGCCCACGCAGGC	GACCACCGTGATGCGAGCGATCCGCAGGGCGAGAGTGACGGGCGGGAGTGGCGGGCGC
ACGTGGCGGCGCAGCACAGGCCCACGCAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080041119.1\|6391643_6392282_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NZ_CP017717.1\|WP_080041118.1\|6389936_6391004_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NZ_CP017717.1\|WP_080041111.1\|6382296_6382902_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_CP017717.1\|WP_080041112.1\|6382991_6383534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080047043.1\|6400535_6401693_-\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NZ_CP017717.1\|WP_080041125.1\|6399225_6400539_-\|allantoinase-AllB	unknown	unknown	gnl\|CDD\|238640
NZ_CP017717.1\|WP_080047040.1\|6388131_6388701_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP017717.1\|WP_080041121.1\|6392664_6393840_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP017717.1\|WP_080041115.1\|6386733_6387528_-\|murein-L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NZ_CP017717.1\|WP_080041122.1\|6395403_6396159_+\|thiazole-synthase	unknown	unknown	gnl\|CDD\|234687
NZ_CP017717.1\|WP_080041113.1\|6384501_6384921_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP017717.1\|WP_080041116.1\|6387644_6388121_+\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NZ_CP017717.1\|WP_080041124.1\|6398284_6399229_-\|allantoicase	unknown	unknown	gnl\|CDD\|237319
NZ_CP017717.1\|WP_155128153.1\|6393972_6395214_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274092
NZ_CP017717.1\|WP_080047041.1\|6395195_6395411_+\|sulfur-carrier-protein-ThiS	unknown	unknown	gnl\|CDD\|340451
NZ_CP017717.1\|WP_080041120.1\|6392259_6392634_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|375793
NZ_CP017717.1\|WP_080041117.1\|6388923_6389844_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	unknown	unknown	gnl\|CDD\|273212
NZ_CP017717.1\|WP_080041123.1\|6396285_6398280_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_155128150.1\|6384928_6386626_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041110.1\|6381000_6382200_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080041119.1\|6391643_6392282_-\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	5.25959e-88
NZ_CP017717.1\|WP_080041118.1\|6389936_6391004_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	4.97433e-65
NZ_CP017717.1\|WP_080041111.1\|6382296_6382902_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	5.02898e-17
NZ_CP017717.1\|WP_080041112.1\|6382991_6383534_+\|hypothetical-protein	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	0.00473152
NZ_CP017717.1\|WP_080047043.1\|6400535_6401693_-\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	1.13346e-161
NZ_CP017717.1\|WP_080041125.1\|6399225_6400539_-\|allantoinase-AllB	gnl\|CDD\|238640	cd01315, L-HYD_ALN, L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in biotechnology). But L-HYDs differ by having an L-enantio specificity and by lacking activity on possible natural substrates such as dihydropyrimidines. Allantoinase catalyzes the hydrolytic cleavage of the five-member ring of allantoin (5-ureidohydantoin) to form allantoic acid.	0
NZ_CP017717.1\|WP_080047040.1\|6388131_6388701_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.34726e-09
NZ_CP017717.1\|WP_080041121.1\|6392664_6393840_-\|oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	2.24456e-54
NZ_CP017717.1\|WP_080041115.1\|6386733_6387528_-\|murein-L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	2.25177e-15
NZ_CP017717.1\|WP_080041113.1\|6384501_6384921_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	7.32302e-42
NZ_CP017717.1\|WP_080041116.1\|6387644_6388121_+\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	2.91028e-63
NZ_CP017717.1\|WP_080041124.1\|6398284_6399229_-\|allantoicase	gnl\|CDD\|237319	PRK13257, PRK13257, allantoicase; Provisional.	1.19939e-166
NZ_CP017717.1\|WP_155128153.1\|6393972_6395214_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|274092	TIGR02352, Glycine_oxidase, glycine oxidase ThiO. This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	7.68337e-96
NZ_CP017717.1\|WP_080047041.1\|6395195_6395411_+\|sulfur-carrier-protein-ThiS	gnl\|CDD\|340451	cd00565, Ubl_ThiS, ubiquitin-like (Ubl) domain found in sulfur carrier protein ThiS. ThiS, also termed Thiamine biosynthesis protein (ThiaminS), is a sulfur carrier protein involved in thiamin biosynthesis in prokaryotes. It has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub), and is activated in an ATP-dependent manner by sulfurtransferases, similar to the activation mechanism of Ub-activating enzyme E1. ThiS has common evolutionary origin with Ub-related protein modifiers in eukaryotes, a beta-grasp fold as Ub, and is closely related to proteins MoaD and Urm1.	1.08587e-18
NZ_CP017717.1\|WP_080041120.1\|6392259_6392634_-\|DNA-binding-protein	gnl\|CDD\|375793	pfam18367, Rv2175c_C, Rv2175c C-terminal domain of unknown function. This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.	9.13334e-32
NZ_CP017717.1\|WP_080041117.1\|6388923_6389844_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	gnl\|CDD\|273212	TIGR00676, 510-methylenetetrahydrofolate_reductase., 5,10-methylenetetrahydrofolate reductase, prokaryotic form. The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family].	6.84541e-127
NZ_CP017717.1\|WP_080041123.1\|6396285_6398280_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.17405e-118
NZ_CP017717.1\|WP_080041122.1\|6395403_6396159_+\|thiazole-synthase	gnl\|CDD\|234687	PRK00208, thiG, thiazole synthase; Reviewed.	1.44667e-150
NZ_CP017717.1\|WP_080041110.1\|6381000_6382200_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.2475e-84

>NZ_CP017717.1|WP_080041118.1|6389936_6391004_+|polyprenyl-synthetase-family-protein
MTTHAAGMETLRAQVERALAEFVERKLPSGGDPEFAPLRTAADELLSGGKRLRPAFCYWGWRGAGGTDEPGVFTAAASLELLQASALVHDDVMDKSDLRRGMPSAHRRFQAMHEKSGWHGSAEQFGEGAAILLGNLLLIWSGEMWRTSGLPREALDAAQPVHDHMRSELMCGQYLDLLEQAHGENTFESALRVALFKSGKYSVEQPLRLGLALAARELTPWMDELCTGYGRRVGIAFQLRDDILGVFGDPAQTGKPAGDDLREGKRTMLVARTLAAASPADADTVRLLLGDPGLDEAGVATLRRIIEGTGALQECEDLIGDYLSQALSALESSPVTPEARKALTELAIAATSRKT
>NZ_CP017717.1|WP_080041117.1|6388923_6389844_-|methylenetetrahydrofolate-reductase-[NAD(P)H]
MALGRSSIRPDRVPTVREMLASGGRSFSFEFFPPKTDEGARQLWRAIRELESLRPTFVSVTYGAGGSTRDRTVDIVERIAHDTTLTPVAHFTAVNHSVRELRHLVGRFADAGVRNILAVRGDPPGDPMGEWVQHPEGVLYAEELVRLIRQAGDFCVGVAAFPYKHPRSPSVESDVEYFVRKCRAGADYAITQMFFQADDYLRLRDRVAAKGCDTPIIPCIMPVTQMSTIARSEQLSGAPFPPDVAARFEAVKDDPAAVRQLGIEHGAELCQRLLDEGAPGIHFITFNRSSASREVFQRLERVPAAT
>NZ_CP017717.1|WP_080047040.1|6388131_6388701_+|GNAT-family-N-acetyltransferase
MIEFRGAGPAEFAERLDTVIDIYTAAMNPPEDQITGRKTIMRNHATYPHFQCYFAELRESSPDAPAPEPLTVGFAYGFRGAPGQWWHDVVLRGLEDRMGTEAANAWMGHAFELAEIHVHPDYQGKGIGRAMIRTLCAGRRERSAVLSTHDQPTAARHLYASMGFTDLLTRFVFPGGSEEYAIAGRPLPL
>NZ_CP017717.1|WP_080041116.1|6387644_6388121_+|YbaK/EbsC-family-protein
MPEKLPANAVLVESALRALGAAGEIVVLPEKAPTAATAAAQLGCEVGAIANSLIFDADGAPLLVLTSGAHRVDVELIARTAGVRKVRRATPEFVRQATGQPIGGVAPVGHPAPVRTLVDNWLGKHEVVWAAGGHPHTVFPTTFDELVRITGGTPVDVE
>NZ_CP017717.1|WP_080041115.1|6386733_6387528_-|murein-L,D-transpeptidase
MAALLTAGVVVVSGCGTQHMERPAQTPLPPVPSPAAAQQGPAAAPEAAVTAPRKTLRLGAKGKAVTWMQKRLTELGYRPGKADGQYGGTTLAAVWAFQKVNGIKPTSTIAKRTWEALEAPRAPKVLVPGGKATRAEVNLTKQIMVLYVRGQVKLITHISSGSGIPYCETTTWQGKEQRFCGSARTPTGNYRTTWRVSGWHKSYLGELYNPIFFNGGIAFHGALSVPLYPASHGCVRMPMNVAGELPGLLGKGVPVHVRGAYKRA
>NZ_CP017717.1|WP_155128150.1|6384928_6386626_-|hypothetical-protein
MTTAFMVDTPAPPVRGRSGAAGARVWWLLAAGWLAQVALRLWLNRYHTMPVANPDETGYLLAARWLAGGAGADLSGSTFYQAGYALLLVPIFWLTSDPALAYRLAVGAGAMAAASAYPAAYVLLRRLRLDRRAALVAAFVAGLSPALLVFSGFALADAILPVVVLAWLTALHDLVAGGAERRRVVAGVVAGGLGAYAMATHLRGTVIVAVCLLVAVALWRRLPRAALIATLASAVAGAVAGDALNAALRAALYPGGPRDLSALLVERLTSVDGQAWALSGAAGQLWYLVTGTWGLAGVGLAGAAALLARRSAPLAPRVLAGALLAATLGIAYASSAALPDEHRVGNFAYGRYLSCVAVAWTLAGLLTLLRARRLAVARCALAAAGLLAVTGGVTAWYAGDRLHRHAFIAFDFPEVIFLTRTFDALDLVTASLSALALLACLTAAALLARPATATPAGRPATAVVGVLALIHLAFIAHLAPSPPAAGPDWLPAPAPPGRVAVEAGVRWNVWVPLSYRVWWTGIERFHGTTPPEGICTAVVQEDAGPPPEGWTVTGARHGWATWSRC
>NZ_CP017717.1|WP_080041113.1|6384501_6384921_+|helix-turn-helix-transcriptional-regulator
MSVAHTEVTPQVEGQVTGPCGDDDCGIRDVLDRIGDKWTVLVLVELSKGVRRFRELHRAVPGISQRMLTLTTRRLCRDGLVERTAYPTIPPQVEYRLTPMGRSLAEAVRRLADWSREHKDAMDDARARWDAGHGLDSED
>NZ_CP017717.1|WP_080041112.1|6382991_6383534_+|hypothetical-protein
MATSQGRGGRVGLVLLALGPALVAAYAGAGYVAIKAAVRAQVTGPEWAGRKAGAAGFTSLGVDTWRLTWWTALVVGLVAVLYLLFGVLLRRGSRGRTLILVVSGLLIVPYALGFGVALFNPPAMLANLYDNPDFLAGLPAWQPFTAWLLLAAGLAQAVGMVLATTRIGRAPAQPRVGSPS
>NZ_CP017717.1|WP_080041111.1|6382296_6382902_+|TetR-family-transcriptional-regulator
MVEGLRERKKQRTRQALIEAALRLFEEKGFEETTLAEIAEQADVSTRTFFSYFASKEDVVFYDTTARLEAAISAMESRRPDETVTGVLLRIIEESFEQATSYQDLTPADAALRMRLILTEPALQARALLLLFDSQLRLAKGLRDAFPGLTLADAAAAVGALIGAIKLTVMATLDDEQTLEDILATAHRAAEVAISGLRTLG
>NZ_CP017717.1|WP_080041110.1|6381000_6382200_-|cytochrome-P450
MSELTLPTARQRPLDPPDEVTALRQQAPIHRMTYADGHQGWLVTGYAAARAVLAGPHFSNRPENNVHPPIRSARMEAAMRPELMRVPPGFFLRMDAPEHTRYRKLLTGQFTVRRMKMLEPRIQEITETCLDAMEAAGPPVDLVQEFALPIPSLVICELLGVPYEDRDRFQADSKLLVNLETKVDDAVAALGRVSAYLHGLIQRKRKEPADDLLSGLLESGELADDELTGVGVLLLIAGHETTANMLGLGTYALLTNPAQLAAMRDDPSVVENGVEELLRYLTIIHLGPIRTALEDVEIEGVTIKAGESVTIHLPAANRDASRFPDAERLDVTRPAGGHLTFGHGIHQCLGQQLARAEMRIAYPALLRRLPGLRLAVTPEEVPMRSDMTIYGVHRLPVTW
>NZ_CP017717.1|WP_080041119.1|6391643_6392282_-|thiamine-phosphate-synthase
MPKPSLSEARLYLCTDGRRDRGDLAEFLDSVLAGGVDIIQLREKGLEAREELALLEVFRDACDRHGKLLAVNDRADIAYAARPDVLHLGQDDLPVTVAREILGDDIVIGRSTHSTAEASAAAVEEGVDYFCCGPIWPTPTKPGRPAPGPPLLRHAASLDTPRPWFGIGGIDLANLDEVLSLGVRRVVVVRAITEADDPGAAAAEFAKRLATA
>NZ_CP017717.1|WP_080041120.1|6392259_6392634_-|DNA-binding-protein
MTLSVAQIDRETDQLVDEWLTLPEVASRLDLPIGRAKQLLRDHKLLGVRRGSGGPQVPAVFLDGKDVMKGLPGTLTVLQDAGYDDVEALRWLFTPDESLPGSPIEAIKAGRHTEVKRRAQALAF
>NZ_CP017717.1|WP_080041121.1|6392664_6393840_-|oxidoreductase
MVMSVNHVVVVGAGLAGVRTVEALRGRGFTGRITLIGEERHRPYDRPPLSKAVLKGDADTSYVDTDLDALGVEFWAGVAAKSLRPGVVETTEGEVPYDGLVISTGADPIRLPGDGPQHVLRTIDDAHELRAVLVPGARVAIIGAGWIGAEVATAARRADCEVTVIESAATPLSTAVGTEIGGRTLPWYDGIDLRLGVMVDSVDEGGVRLVGGEFVDAHVVVTGIGVRPAVEWLADADIDLHNGVVTDEHLRASLPGVVAVGDCAAWWSRRWRTRLRVEHWDTALNAPEVAAATLLGEEAVYDPVPYFWSEQFGHMLQYAGHHPAGDRLIYRGEPEDKWSAVWLTADDTLAAVLAVDRPRDLVQGRRIIDAGSRLDAERLVDPQVPLRDCVV
>NZ_CP017717.1|WP_155128153.1|6393972_6395214_+|FAD-dependent-oxidoreductase
MPAKGAQVDVIVGGGVVGLSVAWRMAREGRPVTVVDPAPGKGASYAAAGMLAPVSEVTYTEGPLLRLGVASLRRWPAFAAELAADAGFTGEGDATGLVTGPGAGTGSGAGAAPAEVRALDLRADGTLDVAFGADDMAALGELAAYMEKLDLPVERLTGRECRRLEPMLAPSVRGGLLAPGDAWVDPRRVTAALLAALERLDVPVVRARATGLLYEGGRVAGVRLAPPSSEPEHEHEHGRGEVPGEVRGERVVVAAGAWSSELAEVPVRPVKGQIMRLRSPQPLLRRCVRGTVHGSSVYLVPRGDGELVVGATQEEMGFDTKVTAGGLYELLRDARELVPGVTELEVADVVAGLRPGTPDNLPLIGPSGTPGLAFATGHHRGGVLLAPLTTAILLGEESELAALCAPGRFREIS
>NZ_CP017717.1|WP_080047041.1|6395195_6395411_+|sulfur-carrier-protein-ThiS
MSGNFMIVVINGSTHEVADGMTVAQAVHTLTSATTGVAVAVNDEVVTRGAWETTALRDRDRVEVLTAVQGG
>NZ_CP017717.1|WP_080041122.1|6395403_6396159_+|thiazole-synthase
MDDLIIAGEKFSSRLIMGTGGAPSLEVLDQALVASGTELTTVAMRRLDPGARGSVLDVLRERDIKVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIADERTLLPDPIETFDAAERLVADGFVVLPYIGDDPALARRLEQAGCAAVMPLGAPIGSGLGIRNPHNIELIVEAASVPVILDAGIGTASDAALAMELGCDAVLLATAVTRAQRPDLMAAAMKAAVTAGRLARQAGRIPRRRYAEASSPMTP
>NZ_CP017717.1|WP_080041123.1|6396285_6398280_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MDTTTADPLVGRLLDGRYRIESRIARGGMATVYLALDIRLDRTVALKVMHRSLAEDPAFVRRFIGEAKSVASLSHPNVVHVFDQGTDNDVVYLSMEYVPGRTLRDILRERGRLPAREALEIMIPVLAALGAAHQAGMVHRDVKPENVLMTDDGRVKVVDFGLAKAIEATNQTRTGVMIGTVGYMAPEQVITGAADVRSDVYAAGIMLFELVTGQQPYDGETPMSVAYRHVHDTVPAPSSVAPEVPPLVDTLVASATAREPEHRPADATAMLVAAVDAHRMLPRTTIPPGTGPVMSHSQPLAAPHATMALPQGAYPGPGPGPGPGMAAPPHGAHSGAASMPQPAPAHTLVQPRAEAPERRRGFRPNWFLVALAVVMVAAVGLTGWYFAQPEYVKVPDLIGQNLAVAEKNLAGAGLLVRKADGQYDEKVAEGLVLSTDPAANVELEKGSTITVVLSLGPKRIVVPNVEGKTANEARAEIAKAGLNVGGVKRLANPDVERDKVIRTSPQAGEKLKEGTKVVIYVSAGLTMPDVGGMPKDQAAEFLTRQGFGVQVNEVDDDAEPCTVIAQAPKAKAEVDKGAQVMVTVSRCQSDIWDFFRRHGEARDDEQFALVPGVIGKNVNDAKAELEALGFQVRVQRLGGGGVVQYQRPLPNSERPAGSLVYLWQ
>NZ_CP017717.1|WP_080041124.1|6398284_6399229_-|allantoicase
MSPFTRLPDLALRTLGGSVLAASDESFAEKESLIRPGRPGFRPQTFGSKGQVYDGWETRRRRAPGHDWALVRLGIPGVIRGVVIDTAWFKGNYPTHASVEAACVEGHPSPAEVLAAAWTEVVPLSKLTGDAEHAFDVHDEGRYTHVRLNIHPDGGVARLRVHGEARPDLSVHDGLGLDLAALANGGLVTACSDEFYSAPNNVLAPGLARHQAEGWETARRRDGGNDWLVIRLAGRGVVRLAEIDTTNLLFNAPAAVTLTGLDGDREIELLPRTRLQPDTPHRFRLGREEPVTHVRVDIHPDGGLARVRLHGHLA
>NZ_CP017717.1|WP_080041125.1|6399225_6400539_-|allantoinase-AllB
MTPFDLVVRSRRTVTPEGERAAAVAVRGERIAALYDYAAPLPAAEDVDLRDLALLPGLVDTHVHVNEPGRTHWEGFDSATRAAAAGGVTTIVDMPLNSLPPAVSCDALDAKLRAAEGQCHVDVAFWGGAVPGNVKDLAPLHGRGVRGFKCFMSPSGVEEFPPLADGELRLALEEVAGFGGLVIVHAEDPELLAEPEGPGYAAFLASRPGASERSAVARLVRLAEETGCRVHVLHVSSAECLDVLEAAQARGVPVSAETCPHYLTLAAEQVPEGGTAYKCCPPIRSESNRDLLWDGLRRGVLSCVVSDHSPSTADLKVPDFAAAWGGISSLQLGLTAVWTEAARRGHGLADVVRWMSAAPAALAGIAGKGGIMAGNDADLVAFDPAADTLVDAARLHHRNPVTPYHGRTLKGAVLTTWLRGRPVDGRPHGRPILEARA
>NZ_CP017717.1|WP_080047043.1|6400535_6401693_-|glycerate-kinase
MVQHVLVAPDKFKGSLTAAEVCSRVSAGLGVPTVELPVADGGDGTVDAAVACGFERVTIDVTGPTGERVAASYAWQPAGTAVVELSEASGLRRLPGGREPLTATSYGTGELIADAVCRGAKRVVLGLGGSACTDGGAGMAQALGARLLDVEGRDLPRGGAALKELARIDMSGFIEVSGVEFVVASDVDNPLLGPHGAAAVYGPQKGATPDDVRTLEAALARLAAVATATHGLMGAVEHDDVVRAMGVAGAPGAGAAGGVGFAALAFLHAEIRPGIDYLLDLLGFGELVKGARLVITGEGSLDEQSLRGKAPVGVAQAAARAGVPVVAVCGRRTLADAELKAAGIEAAYALTDLEPDPARCMAEAGPLLERLAARIAADRRLEGDG

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Crispr_ID: NZ_CP017717_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_14

6537712-6537812

Orphan

Consensus_repeat	Method
TCAGGCGGGACGGCCGTTCCTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_14

>merge|NZ_CP017717|14|6537712-6537812|CRISPRCasFinder
TCAGGCGGGACGGCCGTTCCTGACCGCACGCGAGGTGGCGCTCAGGCGGGCGTTTCGGCCCGCACGCGAGGTGACGCTCAGGCGGGGCGGCCGTTCCTGAC

>NZ_CP017717|14|12|6537712-6537812|CRISPRCasFinder
TCAGGCGGGACGGCCGTTCCTGAC	CGCACGCGAGGTGGCGCTCAGGCGGGCGTTTCGGCCCGCACGCGAGGTGACGC
TCAGGCGGGGCGGCCGTTCCTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080041232.1\|6525405_6525867_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP017717.1\|WP_080047057.1\|6543251_6544253_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173835
NZ_CP017717.1\|WP_080047054.1\|6529650_6530349_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225917
NZ_CP017717.1\|WP_080047055.1\|6531706_6532537_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP017717.1\|WP_080041246.1\|6544294_6545269_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238042
NZ_CP017717.1\|WP_080041237.1\|6532543_6533071_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP017717.1\|WP_080041238.1\|6533103_6534132_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041234.1\|6527160_6528585_+\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_CP017717.1\|WP_080041235.1\|6528695_6529646_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041249.1\|6547033_6548491_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080041236.1\|6530380_6531622_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP017717.1\|WP_080041245.1\|6541189_6542551_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_CP017717.1\|WP_155128179.1\|6525943_6527032_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155128182.1\|6546632_6547085_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041239.1\|6534194_6537122_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613
NZ_CP017717.1\|WP_080041244.1\|6540570_6541188_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379324
NZ_CP017717.1\|WP_080041243.1\|6539425_6540139_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239527
NZ_CP017717.1\|WP_080047056.1\|6542706_6543252_+\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|215520
NZ_CP017717.1\|WP_080041242.1\|6538472_6539342_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017717.1\|WP_080041247.1\|6545328_6546540_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080041243.1\|6539425_6540139_-\|hypothetical-protein	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	6.62901e-05
NZ_CP017717.1\|WP_080041232.1\|6525405_6525867_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	4.25754e-11
NZ_CP017717.1\|WP_080041245.1\|6541189_6542551_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NZ_CP017717.1\|WP_080047055.1\|6531706_6532537_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.15029e-32
NZ_CP017717.1\|WP_080041237.1\|6532543_6533071_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.60382e-36
NZ_CP017717.1\|WP_080041234.1\|6527160_6528585_+\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP017717.1\|WP_080041249.1\|6547033_6548491_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.03182e-47
NZ_CP017717.1\|WP_080041236.1\|6530380_6531622_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.40862e-38
NZ_CP017717.1\|WP_080047057.1\|6543251_6544253_+\|hypothetical-protein	gnl\|CDD\|173835	cd00687, Terpene_cyclase_nonplant_C1, Non-plant Terpene Cyclases, Class 1. This CD includes terpenoid cyclases such as pentalenene synthase and aristolochene synthase which, using an all-trans pathway, catalyze the ionization of farnesyl diphosphate, followed by the formation of a macrocyclic intermediate by bond formation between C1 with either C10 (aristolochene synthase) or C11 (pentalenene synthase), resulting in production of tricyclic hydrocarbon pentalenene or bicyclic hydrocarbon aristolochene. As with other enzymes with the 'terpenoid synthase fold', they have two conserved metal binding motifs, proposed to coordinate Mg2+ ion-bridged binding of the diphosphate moiety of FPP to the enzymes. Metal-triggered substrate ionization initiates catalysis, and the alpha-barrel active site serves as a template to channel and stabilize the conformations of reactive carbocation intermediates through a complex cyclization cascade. These enzymes function in the monomeric form and are found in fungi, bacteria and Dictyostelium.	8.502e-33
NZ_CP017717.1\|WP_080041246.1\|6544294_6545269_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.61201e-10
NZ_CP017717.1\|WP_080041239.1\|6534194_6537122_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0
NZ_CP017717.1\|WP_080041244.1\|6540570_6541188_+\|AAA-family-ATPase	gnl\|CDD\|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	3.20603e-09
NZ_CP017717.1\|WP_080047054.1\|6529650_6530349_-\|hypothetical-protein	gnl\|CDD\|225917	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only].	4.81253e-59
NZ_CP017717.1\|WP_080047056.1\|6542706_6543252_+\|EF-hand-domain-containing-protein	gnl\|CDD\|215520	PLN02964, PLN02964, phosphatidylserine decarboxylase.	0.0080092
NZ_CP017717.1\|WP_080041242.1\|6538472_6539342_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.23552e-13
NZ_CP017717.1\|WP_080041247.1\|6545328_6546540_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.98092e-75

>NZ_CP017717.1|WP_080041239.1|6534194_6537122_-|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MPRIESTAARLAKLGFADAVRAAQLVRQSEADLDDILESLVEVADPDQALVSLIRLIEREPAVLEAVRSDEVLRGRLLAVLGVSAALGEHLVRHPGQVARLAEQRLGEARAELLRAVGAEPGESEPRAAEGGTGALTALRVAYRGRLAHLAARDLTGQATLGEVTAELSDLAGAALEAALAVARTEVEAGEVRFAVIGMGKCGARELNYISDVDVIFVAEPREGADEAKALRAATRLAQAMMRACSATTPEGSLWEVDAGLRPEGRSGPLVRTLASHLAYYRRWAKTWEFQALLKARPVAGDLELGGAYVEAVNEMVWSAATREHFVEDVQAMRRRVEAHVRAEGERQLKLGPGGLRDIEFAVQLLQLVHGRLDPLLRRRATLPALAALSRGGYVGRDDSRGLAEAYTFLRQVEHLLQLHRLRRTHVVPTGDDDLRRLGRALGMQADPVGEFTARWRRHAMEARRLHEKLFYRPLLQAVARLPESEARLSTAAAAARLEALGYVDPRGALRHIANLSTGVSRRAAIQRTLLPVMLGWFADTPDPDAALLGFRQVSDKLGSTPWYLRLLRDETAVAARMARVLGTSRYATGLLMHAPDAVAMLGSDDELAVRPPESLLGEASAAVSRYAGDPEGAVTAVRALRRKELFRTAVADISGLIDIETVGTALSRLNDVTLQAALDAALSKVPPVTSFAIIAMGRLGGMECSYASDADVMFVHSPRPGADEREAGDAAFAVANELRRLLSLPAPDPPLLIDPDLRPEGRQGPLVRTLASYRAYYSRWSAPWEAQALLRARFSAGDAELGAAFTAMIDELRYPQSGLRDDAIREIRRLKARMEAERLPRGADPALHTKLGPGGLSDVEWVAQLLQLCHAGERPSLRTTRTLEALRAAVGEGLLDPDDEAVLAESWRFASRVRDAIMLMKGRPGDSVPRDGGERRMLAQTLGYPPDGSEDFLDDYRRVTRRARKVMDRVFYGA
>NZ_CP017717.1|WP_080041238.1|6533103_6534132_-|hypothetical-protein
MLSVYVDLALGLVVAFLLLSLLVSGLNEAFVRVLSIRSKFLWAYLRDTLDGVGDKAPSWLPGSLRDVLVALPFGPDPRPKHSNQPAPADPGEMPATKTSDSMMNLLYARVREIDHRKRGRTSIANIPPERFAVAVMELAATENGNIPEFLNKLQRIDSPLYGHLKGVWESAQGDLDRFRKGVETWFDGEMQRLSMLYRRYVKWAVALLGVVVTLLFSMDGFEYAKTLLRDNAFRASVTAVTEAGPDAYNELKQQCTGGDPVPCVTELLSEPALVKLMGQAMVSVSIPAQGDPSVQGNFPVWWGRITTPSHWPGFLLTYVALLFGAPFWWDVFRRITGIKSRR
>NZ_CP017717.1|WP_080041237.1|6532543_6533071_-|GNAT-family-N-acetyltransferase
METERLIMRRWREADKEPFAAMNADPEVMEHFPAPLTRAQSDAMVDRIEEQFDRLGYGLWALEVRESGAFIGFAGLALQTFEAPFLPAVEIGWRLARPAWGHGYAIEAARRAARYAFEEAGLDGIISMTAASNVRSQAVMRRLGMTRDPAEDFDHPRVPEGSPLRRHVLYRLKRP
>NZ_CP017717.1|WP_080047055.1|6531706_6532537_+|LysR-family-transcriptional-regulator
MELRQLKGFVAVATSGSVTAAANDLGLAPASVSEQVRRLEAGLGVALFERTARGMRLTEPGTALLARAQGLLDHADEVRRAVTGARRRVRIGALEMLAAAKLPAVIRRLAERRPDLDVSVESRTRQSLLDAVAGGRLDAALLLDLGDRVGGLGFARPAGMDHVDVGEVRLSLVAAPDGDREPLLVSPSGCSIRLAADQLFGAEVPRRELSSITTAREWSRQGLGAALLPDFALGSDLDSGALVELGLDAPALALRLVWMREREPSLRDVLYALSAS
>NZ_CP017717.1|WP_080041236.1|6530380_6531622_-|MFS-transporter
MFGFSLAYFLVILDTTVLTIALPDLRESLGGSLAGQQWAVNAYTVAFAACLLTGGAVADRYGAARVFKLGVASFGVISLLSAAAPNLGVLIGLRALLGVAGALCTGGSLGLLAEMFPQPAARARATGLWAAITGSALAAGPLLGGVLVDLYGWRAVFLLNPPIALISLLAMRKVTSPRGSRMIDWWVQVLACALLGLVAEALIDAAPVAALLALPVLAALVLAERRSHAPALPGGLLAATWPELLAGTVANFAFSGALFVLTLLLQDTQHLSPMAAGLAFLPLTLPMTVNPLLTGRLVARYGPRPPILGGLALIAAGLAGTALTDVLIPWLVVLGFGLSFVLPALMAGMVNSAPPGTAGTAGGVLNAFRQVGATLGVAVMGVIGQPLLTAAVLAALTCAGYAVAARRAVIGVS
>NZ_CP017717.1|WP_080047054.1|6529650_6530349_-|hypothetical-protein
MFFQHSSDIWRDFPELVPAALYAEGITPDADAGARIAAHAERAAARLAGASESDLPEIQAWRRTFARMGLKPTQYRCASEALLRRFRKEGALPRLHPLIDLCNAVSIAYAVPIAVFDVSRITSHVEVRYAAGDETYMTFGGATEQPPAGEVIFADAAGRAHARRWTNRQSGHSAVRDSTANVLIVAEALHDTAAADVEALVATLADELNTLWPVTPKSAILTPAAPRFEFPA
>NZ_CP017717.1|WP_080041235.1|6528695_6529646_+|hypothetical-protein
MTPSSPLTRRGLLKLGAGVAATTALAPVSAASAAEGRFELTAPSTSLIWRKALQDETVLQSFAIDNAHGHIYTVQVKNGAGSDAAGHLCLTKLSLTGSILGHMYLMGFGHGVQIGVEPSGSAAYLWTETDGVPVENSSRGTRLCRFKFVNGQTLTTSSSALTKYSLVPGATNTTCTIDPSTDRLVTRYWSEGSFRFAVFPLASVKAGAPEKLHDIAQPAGLGTFQGYAAYGNFVYILTGNSYDISPPPGNTYITCLDLRTGEQVQRARSVAGQSLNYREPEGMGIQIVSGAPRLCLGLASEPGPRLASIFYKSELI
>NZ_CP017717.1|WP_080041234.1|6527160_6528585_+|type-I-glutamate--ammonia-ligase
MFNSADDVLKFISDEGVQFVDVRFTDLPGTTHHFTFPVENFSASVFTDGLMFDGSSIRGFQQIHESDMLLLPDPSSAVVDPFRQHKTLNLNFFVHDPLTGEAYSRDPRNVARKAEEYLKGTGIADTVYFGPEAEFYIFDDVRFETKQNAGYYYIDSIEGAWNTGKATEGGNLGYKPRYKGGYFPVPPMDHFTDLRSEMVRNLIEVGIDVEMQHHEVGTAGQAEIDFKFGTLLKTADNLMLYKYVIKSTALEYGHTVTFMPKPIFGDNGSGMHCHQSLWKDGSPLFYDEVGYAGLSDTARYYIGGLLKHAPSLLAFTNPTVNSYHRLVPGYEAPVNLVYSQRNRSACVRIPITGSNPKAKRIEFRVPDPSCNPYFAFSAMLMAGIDGIRNKIEPPEPVDKDLYELPPEEARNIPQVPGSLTDVLNALESDHDYLLEGGVFTPDLIETWISYKRENEVDPIRLRPHPHEFELYYDV
>NZ_CP017717.1|WP_155128179.1|6525943_6527032_+|hypothetical-protein
MPHGDDLDQRFNELVAQIDAEQQRKMRAAAKKGARASRRARNAERERLRPAATAWEDPAPRRGGRRIWPALAGVTAVVTAASLVLTLRPGLLTPVGAVPEETMPEETMPVAAPPASMNAGPVPEETTPVRPTAQGPFAGSPAEGWAEGADGFDLPKAKATGGLSEKDVAKGIERTRALLSAAHLDRKTLFGGHPAAFVKLLPRDERSWFTKRLHREGRDGTRSWVTSFAPKTAERASDVVKVRGRTKLSSFRLDGRRGAKLETDHIIVHAVQRPGQPETAIRLVTRQRGTFLIYREGEELVVWVRQMGGSATPARCDVDDAYIHPFYADSAPSTKRPEGAPVDPYDLDAPDPDGDCHASKRT
>NZ_CP017717.1|WP_080041232.1|6525405_6525867_-|RDD-family-protein
MSRNEPRWTQTWLGGVRSAGIDLGYPGERLGLPEEGSGSIAGWGRRIGALVIDWMICTWVVVQLLLRMNPAESPWAPVLVFALQYLVLVGWMGQTFGHRLMGIRVAAMDGGDPRLLPVAVRTVLLALVVPAAIWDRDHRGIHDRASNTMVVRM
>NZ_CP017717.1|WP_080041242.1|6538472_6539342_+|alpha/beta-hydrolase
MRNYVEIMRIDEVGGLRIATFGTGPRTIIAVHGITASLMAWAGAGRRLPEGWSLVAMDLRGRGHSAGLPGPYGLPRHAEDVLRVADHVGAGPDAVLTGHSMGAYVAALAGAQREFARVVLVDGGIPLAPIPEGTDPDAALEAALGPALARLRQTFPSAEAYVDFFKAHPAFAGRWNADVEAYVRYDLTGPEGALRSRAAGEAVLADGRWLHLEREAIGAALTAIKAPLFLLRAPRGLLDQETGMLPDDLVRPWKERLPGLRDEVVPDCNHYTILFDERCVATVVDRLTA
>NZ_CP017717.1|WP_080041243.1|6539425_6540139_-|hypothetical-protein
MTTAALQTVLTVPQRFRGPVGVANGGWIAGTMAEALNGGRSAVEVTLHAPTPLETELRLEHVANTVSLSHGDKLLVEAIPVAEELEGPGFVPFNDAARAEAGFAGLKAHPFAECFACGLREPGDGLRIFPGPVEGSDLVAAGWRVPFTVTGEDGVPASIVGAVLDCITGWAHFGPGESALLGRLAVQIHRPVLPGGRYSVVARPTGRDGRKMFGQSAIYEVDGTLVAAARATWIAPR
>NZ_CP017717.1|WP_080041244.1|6540570_6541188_+|AAA-family-ATPase
MLRVEGARLRYPPGALVILTGLPGAGKTTLLRRLYGMHGAESLPVTSGAVAVIDSAQSKRHWQGRLAWAPYPVRRAVVFVTHVTRIRQALTQGHAVVAHNRGCGPYVLRGFAWLARRHGADFHLLLLDAPPDEALAGQRARGRVVAARTFARHQRRWDSLLARVKGGDPAPAAGARIMDRAEAGLLEAIVFDSISGTGPRRPSRT
>NZ_CP017717.1|WP_080041245.1|6541189_6542551_-|glutamine-synthetase
MDRQQEFVLRTLEERDIRFIRLWFTDVLGFLKSVAIAPAELEGAFAEGIGFDGSAIEGFARVYESDMLAKPDPATFQILPWRSETPGAARIFCDILMPDGTPSHADPRWVLKRTLAKCADMGFTFYTHPEIEFFLLKNRPEPGQRPEPIDSGGYFDHTPHSSGHDFRRQAIMMLESMGISVEFSHHEGAPGQQEIDLRYADALTTADNIMTFRLVMKEVALEQGIWASFMPKPFTEHPGSGMHTHMSLFEGDRNAFYEAGTDYRLSKIGRSFIAGLLRHAAEITAVTNQWVNSYKRLWGGAEAIAGLGGEAPSYVCWGHNNRSALVRVPMYKPHKGGSTRIEFRSLDSACNPYLAFALILAAGLKGIEESYDLPPAAEDNVWTLTSAERRALGIQPLPGSLNDAIEVMERSELVAETLGEHVFDFFLRNKRSEWREYRRHVTEFELGRYLPVL
>NZ_CP017717.1|WP_080047056.1|6542706_6543252_+|EF-hand-domain-containing-protein
MAIDLLNHKLDRAFDHIDASGNGVVEREDLLGLGARILVGFGESPTSVTGASLVESFDRIWSTLSETLERDGDSGIARPDFRRGMTAAFVEGDRYDAVFRPATVAVAELCDGDDDGQIGPGEFRTMLCAFGVAYDDVDEAFDRLDRAGRGALTVEELVVAAADYYRGDDPNAAGNWLFGPL
>NZ_CP017717.1|WP_080047057.1|6543251_6544253_+|hypothetical-protein
MTTTTTGTTVFAAVRSTVRTALRSALTSLLPLPRRGGSAALALLPLTERVPAMAAPCRMHPAVYAIEAAVIDWARRTGLRADPGVGYHRMAGRAFAEFDAAAAALFAQWLTWLFHLDDELDEHSGPLEIFHGMLKGSSRHPLEAAFADLWRVTSVRMSDRWRARFAVGLQRQYDACRAEAENRAAGRMPTLEEYPALRRGTVGPYLYDLVEPCLRVEVPVWLHESDPWRQLVDACSDVTAWCNDVASRPKERGDVHNFVVLAMRQLGLGEREATAWVLDRIAGRCLDMRKAARRLPLDDLEPKTARDVSKVACAYLAAPRAHLDWLLESQRYA
>NZ_CP017717.1|WP_080041246.1|6544294_6545269_-|winged-helix-turn-helix-transcriptional-regulator
MSITWVLTPDDVARIRFAFSPLWELVASLRTLQQPARQSIHLPWIKAVRPRLAGLDLSELFALVPPTGYLADFITPPPDTPLPDFAAELDRVRRTDPEQARREIGRIQGTDPAALARFAADPAAGVSRVADALETYWEECFAEFWPRVYALLERDVLRRSRQLARGGARELFAGLDPAVVWTGERLLIDRPWCADGGLNGDGLILVPSAFYWPAVAVMTAPYQPMLVYPVHGVGTLWEQGPPPAPGALSALIGRSRAAILLALAEPATTSALAARMALTPGAVSQHLGVLSGGGLAVGMRIGKQVVYRRTLAGDMLAAGPAPHA
>NZ_CP017717.1|WP_080041247.1|6545328_6546540_+|MFS-transporter
MSSSTVEKTSFLKAQVAGLPRPFWALWGGTLVNRLGTMVMPFTGVYLTQSRGLSVAAAGLVMGLFGAGSLLSQLVAGVLTDRIGRRATLSGGMLATAVCMLALGYSTSLPAILASMFALGLVVDVYRPASSALVADLVSPEERPRAYGLLFWAINLGYSVGMTAGGWLAGLGFVWLFWIDALSSVVFAVLVWRAVPETRPETRQKTGGFGVVLRDRVMVGFTLVVLGNALVYAQTMTMLPVAMTGVVKLSSQEFGLAMAMNGILIVIVQPLVSGRLGRMDPARTFALGVAVMAAGFAMTAFVTSTLGLAVTIAIWTAGEIITAGIPGAIVAALAPPELRGRYSGLFGLAWSLAAVLAPLAGGPLLELGPRVLWFTIGGVGLAAAAGMLLLGPAVRRRDPVSSL
>NZ_CP017717.1|WP_155128182.1|6546632_6547085_+|hypothetical-protein
MRRAGLARGVAIGMATLAVVFELTDIWVTAQLPQPSWTPLPLAPEDMAGTAFSVFGAILVHSRPRLVIGWLLCAGGLSAAANILTANTFHLLHGDPAAGRPIINLTWHVLQLTLGVLLPSSTRRAGCCRGAGAGWSCWPWRAWPSTGPAC
>NZ_CP017717.1|WP_080041249.1|6547033_6548491_+|sensor-histidine-kinase
MVVLAVAGMALDWAGVLSGQGALRHPAHWTVSAAMTLAFVSLVVRFARGDATERRQLLWVMVTLPGLLVPWVLGDPFWWLATLFIPLIPAAIAVAVLRYRLFGIDTLISRALIGTGLIIVTTGVYVAASAASSIFLAEVDRVAGVAAAVFAGAAFQPMRRGMQRGIDRLLYGSTGVPGTLARRLRHRLQHADPVHGLLATLDTLREGLSVTGVTVELDGAVTTSGTVSAGAPARVIPLVWHGEPVGLLLVGPTDRRRFPAAHDERVLATLTPYIADAAHAVRLTAALQRSRERILTAREEERRRLRRDLHDGLGQSLTGMAMSINAARLSVRTAPERADLLLAELRAGMDAVSGDIRQLVYGLRPPALDELGLAGALAELAGAPVEVSGRLDGLPAAVEVAAYRIVQEALTNARKHAGAATITVALRRGETLRITVTDDGSGIPADARPGVGLGSMRERAAELGGTCVVRDAAGGGTVVEAELPL

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Crispr_ID: NZ_CP017717_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_15

6917230-6917313

Orphan

Consensus_repeat	Method
CTACGAACGACGGTCGTGGTCGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_15

>merge|NZ_CP017717|15|6917230-6917313|CRISPRCasFinder
CTACGAACGACGGTCGTGGTCGTGATCGGGGTCGTGGTGGCGGGGGCGGGGACGAACCAACTACGAACGACGGTCGGGGTCGTG

>NZ_CP017717|15|13|6917230-6917313|CRISPRCasFinder
CTACGAACGACGGTCGTGGTCGTG	ATCGGGGTCGTGGTGGCGGGGGCGGGGACGAACCAA
CTACGAACGACGGTCGGGGTCGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080041527.1\|6925435_6926962_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224458
NZ_CP017717.1\|WP_080041516.1\|6910115_6910799_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225462
NZ_CP017717.1\|WP_080041528.1\|6926983_6927574_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370723
NZ_CP017717.1\|WP_080041520.1\|6913921_6915214_-\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NZ_CP017717.1\|WP_155128274.1\|6917633_6918266_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236608
NZ_CP017717.1\|WP_080041525.1\|6921465_6923379_+\|primary-amine-oxidase	unknown	unknown	gnl\|CDD\|236919
NZ_CP017717.1\|WP_155129870.1\|6910896_6912075_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|275139
NZ_CP017717.1\|WP_080047090.1\|6905899_6906919_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041526.1\|6923738_6925439_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99743
NZ_CP017717.1\|WP_080041529.1\|6927588_6928377_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041524.1\|6920535_6921192_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_080041522.1\|6916671_6917028_+\|zf-HC2-domain-containing-protein	unknown	unknown	gnl\|CDD\|379219
NZ_CP017717.1\|WP_080041515.1\|6908834_6910070_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP017717.1\|WP_080041521.1\|6915210_6916557_-\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	unknown	unknown	gnl\|CDD\|274583
NZ_CP017717.1\|WP_155128272.1\|6907371_6908829_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041519.1\|6913213_6913921_-\|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl\|CDD\|132483
NZ_CP017717.1\|WP_080041530.1\|6928404_6928833_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041518.1\|6912212_6913193_-\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|378355
NZ_CP017717.1\|WP_080041523.1\|6919260_6920316_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP017717.1\|WP_080041531.1\|6928847_6929411_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080041516.1\|6910115_6910799_-\|NAD(P)H-binding-protein	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	2.19198e-61
NZ_CP017717.1\|WP_080041528.1\|6926983_6927574_+\|hypothetical-protein	gnl\|CDD\|370723	pfam09849, DUF2076, Uncharacterized protein conserved in bacteria (DUF2076). This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	0.00100885
NZ_CP017717.1\|WP_080041520.1\|6913921_6915214_-\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	9.6595e-156
NZ_CP017717.1\|WP_155128274.1\|6917633_6918266_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	3.90484e-33
NZ_CP017717.1\|WP_080041525.1\|6921465_6923379_+\|primary-amine-oxidase	gnl\|CDD\|236919	PRK11504, tynA, primary-amine oxidase.	0
NZ_CP017717.1\|WP_155129870.1\|6910896_6912075_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|275139	TIGR04343, pyridoxal-phosphate-dependent_transferase, ergothioneine biosynthesis PLP-dependent enzyme EgtE. Members of this protein family are the pyridoxal phosphate-dependent enzyme EgtE, which catalyzes the final step in the biosynthesis of ergothioneine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	6.04601e-96
NZ_CP017717.1\|WP_080041523.1\|6919260_6920316_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	6.48646e-114
NZ_CP017717.1\|WP_080041526.1\|6923738_6925439_+\|hypothetical-protein	gnl\|CDD\|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	6.36781e-74
NZ_CP017717.1\|WP_080041524.1\|6920535_6921192_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.51182e-15
NZ_CP017717.1\|WP_080041522.1\|6916671_6917028_+\|zf-HC2-domain-containing-protein	gnl\|CDD\|379219	pfam13490, zf-HC2, Putative zinc-finger. This is a putative zinc-finger found in some anti-sigma factor proteins.	1.55471e-05
NZ_CP017717.1\|WP_080041515.1\|6908834_6910070_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	1.18209e-66
NZ_CP017717.1\|WP_080041521.1\|6915210_6916557_-\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	gnl\|CDD\|274583	TIGR03444, EgtA_Cys_ligase, ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	8.58711e-106
NZ_CP017717.1\|WP_080041527.1\|6925435_6926962_+\|hypothetical-protein	gnl\|CDD\|224458	COG1541, PaaK, Coenzyme F390 synthetase [Coenzyme metabolism].	2.14757e-12
NZ_CP017717.1\|WP_080041519.1\|6913213_6913921_-\|ergothioneine-biosynthesis-protein-EgtC	gnl\|CDD\|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.93766e-96
NZ_CP017717.1\|WP_080041518.1\|6912212_6913193_-\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	3.25159e-156

>NZ_CP017717.1|WP_080041522.1|6916671_6917028_+|zf-HC2-domain-containing-protein
MEEGSLGCTDVLALATDYLDEALPPARHRTVGEHLDACRDCSAWLAQLLATIAALGCLRDGIITRPVLTALRDSFSRRKGQPAGTCPTAVGDGGADGKAAGTGGGERRGGGTDENPRG
>NZ_CP017717.1|WP_080041521.1|6915210_6916557_-|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA
MIGVTAESTPLRDVTEVAGYARRCFRPAGDRVGVELEFLVFDRADPGGHVPMERTERALPARLPGGSRVTFEPGGQLELSGPAGALPDTITRLSADVAAVRAGLRAAGLVLGGVGLDPVRVPCRQLGLPRYEAMAEFLGAPFGPLMMCSTASIQVNLDFGRQPGVRWERAHALGPVLLAAFANSPLSGGRPYGWMSGRQDVWNNLDPTRTRPVPVTGDPVADWAEYLLDARLMLVREDDERYRPVRDGSTFRDWVNGAGEGPKSGAGRSDGGGRGDGGVRRPTLEDLAYHATTVFPPVRPRGWLEVRYLDAQHPAVWPVCVAVTHALITDDRAGDAAIAAVPTEAGGQEEWDRAARCGLADPRLRNAAEVGFRAALEALPRLGADAALVGAVAAFADRYVRKGRSPAADLMEAPHPAPPWLDDDQDPSADHDGQGPHADHDPVHEGHA
>NZ_CP017717.1|WP_080041520.1|6913921_6915214_-|ergothioneine-biosynthesis-protein-EgtB
MNDIKERIARELIAVRDRSLAYTDADDDLLVNQHSPLMSPLVWDLAHVGNYEELWVLRAAAGITPLRPEIDDIYDAFKTPRKDRPSLPFLRPAEARGYIEGVRGRVLDVLDEVDLEGPSPLHRDGFVFGLVIQHEHQHDETMLATLQLSGQPGLVRDGELPPGGAGGPEEVHVPAGPFLMGTDTLPWAYDNERPATWVDLPGYWIDRLPVGNRAYLAFMEDGGYDDPRWWTPEGWQWRQRRGITAPLFWTSDGGTWHRTRFGRVEPVPMDEPVQHVSWYEADAYARWAGKRLPTEAEWEKACGWDPEARRSRRYPWGEADPGPSLANLGHRASHPAPLGAYPAGASAYGAEQMVGDVWEWTSSWFHGYPGFRSFPYKEYSEVFFGEEYRVLRGGSWAADPAAVRTTFRNWDYPIRRQIFTGFRCARSELV
>NZ_CP017717.1|WP_080041519.1|6913213_6913921_-|ergothioneine-biosynthesis-protein-EgtC
MCRHAAWLGAERSLASLIDEPEHGLLKQSYAPRRQRHGMVNADGYGMGWYVPGRPEPVRYRRSVPIWTDANLPGLAAVARSTCLLAAVRSATVGMPVEESATAPFTDRTWLLSHNGRVARDAVADLCDAAESTCDAAWVAGAVFQRGRAGAGLGESLAEVVVQAGEKDPAARLNLLASDGTTLAATVWGDTLFHHRFHDGVLVASEPLDDLPGWQAVPERSLLTVTRDDVRVQPL
>NZ_CP017717.1|WP_080041518.1|6912212_6913193_-|L-histidine-N(alpha)-methyltransferase
MPVTQSTVRVISHLDRDYLRQALEHDVTTGLTSTPKWLPPKWFYDATGSELFSRITRLPEYYPTRRELAILRARAADLAAVSGADTLVELGSGTSEKTVLLLDALSAAGTLRGYTPVDVDAVTLDAAAHRLAGRYPGLTVRAVCADFERHLALLPRNGRRMVAFLGGTIGNLEPAARAVFLKELRATLRPGDTFLLGADLVKDRGRLVAAYDDSAGVTAAFNRNVLHVINRELDADFEPDAFEHVALYDERHDWIEMRLRASREMRVRVGGLGLEVSFEAGEEMRTEISAKFRPEGLRMELETAGFGVRRHYTDPAGDFALVLAEA
>NZ_CP017717.1|WP_155129870.1|6910896_6912075_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPSGHLDAAGCNVPADRVLDAMTAHLRRERERGGYAAVPDLTAARAALAALVEPALVEPGLAEPVQVGPALVDPARGGSRQVAFLESGTAVMAALLGGWRLAPGSRVGCARTEYGGTLMLLRRLAAQRGWRLVELPVDGDARIDPDGVRARLASGLDLVVVSHVGSHHGVVQPAAELAALCRAAGVPFVLDVCQSLGHVEVRGIGATAYVGTSRKWLAGPRGVGFLIVPELSPAMDAPAPTLSGHVWEGPGWERGEVAPVEGAARFESSEGPVAARAGLAAAVEELHALGPSAVHAHLAELGRTARALLDGVGGWRVAEPLDEPSALVTLAPPPGDSAERAAARAAEASLLVGVVPTARAPLHLREPVLRVSPPPGTSLDTLRALAGVLAAA
>NZ_CP017717.1|WP_080041516.1|6910115_6910799_-|NAD(P)H-binding-protein
MRIGVFGATGVIGSRVVAEAVARGHDVTAFTRDATRVPAGAGQVTWRVADVMDVPAMTEAIAGLDVIVNALNAGRDIPETIANAHVFPAAARSLLEALESHPAARLIVVGGAGSLEVRPGLQVVDTEGFAEGLPANLGVPEEYVKVVLAHREALALYRLSNRRWTYLSPSSGRVDPGERTGRFRVGGDRLLVRDDGTSAISAEDLAVAVVDEAELPRHVQRRFTVGY
>NZ_CP017717.1|WP_080041515.1|6908834_6910070_-|exo-alpha-sialidase
MEAIMRKLRTLGAALGAVLLMAITAAPAAAAQPPTRTWHKQTLWKQFTSTDPATGATLTTCFRLPAVVRTSRNVLLAFAERRNRNNCADHGAFDVVMRRSTDHGVTWGASTDVLKSTAGAALQGNATVVADSAGPVFLFTTSEPTATQTTPRTPKVQVSRDDGVTWSDPEDLSGVIKAPAGAGDWFATGPGHGIQLTRGTHAGRLVVPVYFAVGSRQSVRLIYSDDHGGTWNAGATATYDKSVLKLGEQTLVERTDGSILVIARNGAVPDDQTSVHGLATGVSRDGGLTFDGGFRADTAVTAPPTHPALLRQRWDGGSYTRILLSAPATPKTDNNPVGMNVRSSFDEGATWRDHDGTIDNAGVRIDGDHAGYSDLALLGNGAIGVLYEAGAARFRDEIRWNWFWESAIGLR
>NZ_CP017717.1|WP_155128272.1|6907371_6908829_+|hypothetical-protein
MAGMDVAAAEVAHAELLTALAGRPLVVVDRYSTALRTGYTGPMPVEALRPALGIGCYAAWDPALPGMVVAAEEQTGSRSVAGRRGWLRRVRHEAARHLVKLDRPPVIATCHTGAQLQELAGPGGTVAAIEAGVRATIEARHLFDDLLRAAGVPAVARIRCVPAERLPGLAELRRAVGTERVVVQAGDGYGGRGTVIVSGEEDMSRAARLLGPYRVAAYVDGWPCTVTALSVPNLTGGVGVYVDRPAHETTGVAELGLGPLCSAGHDWSRPWPLPAAALLIECAERIAVWAWRRYGVAGLFSLRGLLTPDERVYLSAVRWRCDDSTEVSAVNQQAVGVPPFLPAHLVVMLGGRVSWLPDPQEFNQVSLLRATERGGPFSVRVRLRGDTPLRVAAGQGPGVYRLDRADRPRWVRRAAHPAEALADLGEFLLAGLPATDVVCHPGADLATIEAVTDGATQPFHGPAGASPFTRRVAAAVETLLVPASP
>NZ_CP017717.1|WP_080047090.1|6905899_6906919_-|hypothetical-protein
MLNRRTVLTAGTFTLAALSGLAGRGVPAVAALPGLVRHGTRAPAARAGAGDVARVRAATAAFADLDDRFGGGHARAAVAAYLSREVTPLLGVAGGRARPDLFTAAAELSYLAAYMAMDAGANALAQRYYISTVRLADEAGDLVLRATALRSMAVQAAELGHDAEALALADAAASALGGRGPRRTLAWITGMRAEAHAAAGTRWDALTLLRRTETQLERADSPPETEWLGNYRRESLEHQIGLTLTQLGDHATAARHFTASMEARQPVELRTRVLIGLRAAHASVRAGDPEQAAVTVLGLSDDVRLIASARVHDELRRLRAGWQRYRTSPLVAEADAAVS
>NZ_CP017717.1|WP_155128274.1|6917633_6918266_-|sigma-70-family-RNA-polymerase-sigma-factor
MGSFEGGGLPPDDIVVGALRDGDEAMFAALLDTWSRGMLRVARSYVSTDHSAEEVVQDTWLAVIDGIDAFEGRASVKTWVFRILVNTAKKRGVRESRTLPWSAFERDGDVFADLGAAAQGARVDGASGWPTPEGEALAAEVRVLIAEALGRLPPRQRVVITLRDVEGCTSDEVCEILEISAANQRVLLHRARTAVRGWLADYYESVKQPE
>NZ_CP017717.1|WP_080041523.1|6919260_6920316_-|TerC/Alx-family-metal-homeostasis-membrane-protein
MSAGTILHAAEPLRTIASPTLWAVTVAALLLLLLIDLLITRRPREESMRASVAWSVFYLLLPVLFGLYLWAGHGGGAAVEFYTGFVVEKSLSVDNLFVFMLLLAAFAVPSALARQVLLYGIVGALVLRVIFIWLGAAALQSGTWAFLLFGAILIVTAGKIIKDVLRGDEQEVDISSMRSVRFVRRFVPVTEDYRGSRLVVRERGRLALTPLALAAVAILATDIVFAVDSVPAVYGVTEDPFLVFATNAFALLGLRALYFVLQGVLTKLRHLNHGLSVILAFIGVKLILHWAHGVWTWVPEIPTLASLGVIVAVLITVTATSLLANHRDRLRPSPAAQVEPVEPVEEPAGER
>NZ_CP017717.1|WP_080041524.1|6920535_6921192_+|TetR/AcrR-family-transcriptional-regulator
MGRIAGVTAAETRERLLLAAAEVFAERGYDGTRVADIAAAAGVSNGALYAHFGSKAELLVAALRAHGRNQLASLFEADPDRSATELLLAIGRTLNRRRDPPGHLIVEALVAARRDEDVAGPMRDYVGERAAWIADLVRVAQGDDELDPALSPDAVAHFCLLLGMGSALVTPDLHGVGDEEWAALLARVVTALAPPEKETAPPPPENETALPPPGDESD
>NZ_CP017717.1|WP_080041525.1|6921465_6923379_+|primary-amine-oxidase
MTATPHPLDPLTPGEIAAARTVLAAAGLIKDTIRFAYLGLEEPPKDALLAYAPGDPMDRRVRVLLLDTAGAATRDVVVSLTRGTIDADRTLDPVMDGQPPVLDAEFGIVEEVLATDERWIAALKSRGLDVSKVRVAPLSAGVYADEYPGESGRRILRGLAFVQEHEKDHAWAHPVDGLVAYVDVLNRTVDQVLDSGPVPIPAGSGNFDDPAVTGPPRTTQRPIEITQPEGPSFTLEGGLLRWENWSLRLGFDAREGLILHQIAFHDRDAGRERPIVHRASIAEMVVPYADPSPVRSWQNYFDAGEYLLGQYANALERGCDCVGEITYLDAVIADEHGVPRTLPNAICLHEEDHGILWKHTDLWTGSAEVRRQRRLVLSFFTTVGNYDYGFYWYLYLDGTIAFEAKATGVLFTSAYPPDGSDHASEVAPGLGAPYHQHLFCARLDMAVDGPANRVEEVDLARVPMGPGNPRGNAFTYRRTPLTRESGAQRDADASVGRTWQITNPAALNALGRPVAYALQPEGRPVLLAAPGSSIAKRAAFATRHLWVTAYDPDERYPAGFLVNQHPGGAGLPAFAAADRDLDGRSLVVWHVFGLTHVPRPEDWPIMPVERTGFSLRPVGFFDRNPTLDVPAHHGHGA
>NZ_CP017717.1|WP_080041526.1|6923738_6925439_+|hypothetical-protein
MAARTSGPTGRSSITFSAEASERSHRVQFFRRSSCRARNSGEHSTEAALTPSGPQEPELSAPPADPGGLTLKPFDVRLFRESSETTVAKLEKHLADLSLKGLSLTEPAVLSRAARALMTTEREHIAGYDEDRLAAIIDLYVKTGIQVHSPGYMGRQFSSTVPLAGVIDFVSSVVNQPSSFYEAGQLPNVVEKIMADELNRFIGWPADSFAMVTTSGGSLANLTAMLAARNDRFPGFWSEGSAAYLGQARPAIAVGDDVHYSVSRTAGVMGIGEAQIVRLPLNAAQQIDMDAVRPALDAAERRGLGVFCLVASAGTTSVGAFDPIDRLAEVARERDIWLHVDGAHGASLLVSDQLRHRLKGIELADSLTWDAHKMMFTPAPCTLLFYREKDKSRRAFRQRASYVFDEDPDVYTAMDSGGKTIECTKRPMIMPLWVVWAMYGRALFAEKIEYLCRLTRDVHRVLQAEPDFETTHYPESNILCFRYRPGWVREEDVHRLQVTVRDRVKSRGTFFISKVDVAGVAALRVVMMNHLITEEHFRMLLDEIRAVGEELCGNRQNDQQRVGGRR
>NZ_CP017717.1|WP_080041527.1|6925435_6926962_+|hypothetical-protein
MSPSTTDPRTLAAKLIPEEDLAPPSVEAVPALPSFASRMHEFERAFRTPYSELPHEVQDALVLRRLRQLVGTVRLNPAWRERLRDCGEPMTYEDWQAIPLADKDAQRDLYMEGRPGLVVPLDRGGFEVVASGGTSGGAPLEIVYALRELHDTYRVAGRFLGAYQLGRYLPDGEGPKWLCTTLADYQMWSSGTMVGGVLQHVPGVNYIGAGPVTAGVLEHMFSYPGPKALMGISAGIAILSDLGQGLKREARESFRVALYGSGVLAHRKRAELKAVYPNLTILSYFAATQAETIGLQLEETSPCLTAVPGLHLVEIVDDKGRWVGEGEEGELVVTRLHAHEAPLLRLKLGDRMIRRPRLDGPGPRAERFEFAGRTGDVLHIADSQYSAARAYAAVREDLRLVTPVDLDEVAHEVQFVNQREERSITLLAAVDDVAALTYATEAALGPYGAHHVFVNALPRSLSLFNQGEANAASIEKTGYRFHLRFVPRSSPEIERTSVGKVPLVRDRG
>NZ_CP017717.1|WP_080041528.1|6926983_6927574_+|hypothetical-protein
MAVKPQVNIIALVDVIGALSDRSLLNGNLVMIDDGSFASRAQGTPDLCTVVQPGQVVQWTALAVDLQTPVEIKNIEFLRLQPPPGQPAYPAPQPGWAGPAGAPPGGMMPAPMQQQPAYAGAAPGYGPGAYPPGPTGPAAVTGAPTTESEKLDLEIWAGVVPYYMVPGVAYRYRLEFQMYEGPYSVLYVETPSLMRI
>NZ_CP017717.1|WP_080041529.1|6927588_6928377_+|hypothetical-protein
MPQQLAIIVLVDVGNALEMKTLEGNTYLFDNMKLHGSEGQGTGELVTAIHGSYWRDGSQASEQVLNWLPYSLGSIPPTVPRGYEAERARQTDRQALAELEAMVNKPANQGADAAAQISQLQQTLGTRVKSTRRTRGPATQKILDVTGHVISYDGAAAHSYPPPVITDIYGEAVDKKIMYPAEYGSPDMVTDGWYWSATVDSTRPGTYTYTMAIQLHRLLLQGGDWTWEPVDLTCDSKIRIMSEPKRNAFTKSGLGLLPIPPA
>NZ_CP017717.1|WP_080041530.1|6928404_6928833_+|hypothetical-protein
MPPRAKTRDDSRAPISITAVLDAVGALAAGSVRGNLYMYDTNKAGGSTGFGTEELRTRVRAGDRVLWNCLALECEAFVGIAGIEVDKSVIEPERKVYPGTDVAYWIGTVKKDDIDVVPYRIRFLVGTRTEPITTTLSPTLVG
>NZ_CP017717.1|WP_080041531.1|6928847_6929411_+|hypothetical-protein
MVMPSTKARSGGVEKQNPGQLNSVQLNIVTLVDMEKATENKSLSGAMYMVDNSVGGSGQGTSRLETVCKPGQVLNWIIRPIDMERRRDGTWPPMPKINNIVFLDVEAGDEEDVAEKKVCVELKIYGAPDRMRDDLTPVYYYWAGTVLPTIKPGTYRYRLVVELEQENKKERLYLNTEGHPSIRVIPV

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Crispr_ID: NZ_CP017717_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_16

7329893-7329988

Orphan

Consensus_repeat	Method
CGAGAACGGGCCTGAAAGCGAGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_16

>merge|NZ_CP017717|16|7329893-7329988|CRISPRCasFinder
AGAAGACGGGCCCTGCACCGAGAACGGGCCTGAAAGCGAGAACAGGCCCGCAAGCGACAACAGGCGGCAAGCGACAACGGGCCTGAAAGCGAGAAC

>NZ_CP017717|16|14|7329893-7329988|CRISPRCasFinder
AGAAGACGGGCCCTGCACCGAGAAC	GGGCCTGAAAGCGAGAACAGGCCCGCAAGCGACAACAGGCGGCAAG
CGACAACGGGCCTGAAAGCGAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080041846.1\|7317475_7318969_+\|cytochrome-bc-complex-cytochrome-b-subunit	unknown	unknown	gnl\|CDD\|224209
NZ_CP017717.1\|WP_080047116.1\|7320742_7321675_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|273938
NZ_CP017717.1\|WP_080041850.1\|7323505_7324702_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP017717.1\|WP_080041848.1\|7321590_7322535_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|184242
NZ_CP017717.1\|WP_080041859.1\|7337246_7338131_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP017717.1\|WP_080047117.1\|7330066_7331431_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NZ_CP017717.1\|WP_080041858.1\|7336470_7337250_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|163190
NZ_CP017717.1\|WP_155128360.1\|7339355_7340594_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340911
NZ_CP017717.1\|WP_080041853.1\|7331546_7331834_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NZ_CP017717.1\|WP_080041845.1\|7313767_7314184_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041860.1\|7338131_7339265_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP017717.1\|WP_155129894.1\|7320066_7320720_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP017717.1\|WP_080041856.1\|7333863_7335567_-\|glyoxylate-carboligase	unknown	unknown	gnl\|CDD\|183066
NZ_CP017717.1\|WP_080041855.1\|7332269_7333805_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|365919
NZ_CP017717.1\|WP_080041852.1\|7328516_7329809_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NZ_CP017717.1\|WP_080047115.1\|7314738_7317375_-\|pyruvate,-phosphate-dikinase	unknown	unknown	gnl\|CDD\|236446
NZ_CP017717.1\|WP_080041854.1\|7331916_7332273_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041851.1\|7324916_7328027_-\|zinc-carboxypeptidase	unknown	unknown	gnl\|CDD\|349432
NZ_CP017717.1\|WP_080041849.1\|7322531_7323509_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP017717.1\|WP_080041857.1\|7335581_7336442_-\|2-hydroxy-3-oxopropionate-reductase	unknown	unknown	gnl\|CDD\|224995

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080041846.1\|7317475_7318969_+\|cytochrome-bc-complex-cytochrome-b-subunit	gnl\|CDD\|224209	COG1290, QcrB, Cytochrome b subunit of the bc complex [Energy production and conversion].	8.75121e-49
NZ_CP017717.1\|WP_080047116.1\|7320742_7321675_-\|trypsin-like-serine-protease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	2.15032e-64
NZ_CP017717.1\|WP_080041850.1\|7323505_7324702_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.8036e-82
NZ_CP017717.1\|WP_080041848.1\|7321590_7322535_-\|VWA-domain-containing-protein	gnl\|CDD\|184242	PRK13685, PRK13685, hypothetical protein; Provisional.	2.42884e-98
NZ_CP017717.1\|WP_080047117.1\|7330066_7331431_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_CP017717.1\|WP_080041858.1\|7336470_7337250_-\|TIM-barrel-protein	gnl\|CDD\|163190	TIGR03234, OH-pyruv-isom, hydroxypyruvate isomerase. This enzyme interconverts tartronate semi-aldehyde (TSA, aka 2-hydroxy 3-oxopropionate) and hydroxypyruvate. The E. coli enzyme has been characterized and found to be specific for TSA, contain no cofactors, and have a rather high Km for hydroxypyruvate of 12.5 mM. The gene is ofter found in association with glyoxalate carboligase (which produces TSA), but has been shown to have no effect on growth on glyoxalate when knocked out. This is consistent with the fact that the gene for tartronate semialdehyde reductase (glxR) is also associated and may have primary responsibility for the catabolism of TSA.	4.00447e-87
NZ_CP017717.1\|WP_155128360.1\|7339355_7340594_+\|MFS-transporter	gnl\|CDD\|340911	cd17353, MFS_OFA_like, Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.29587e-45
NZ_CP017717.1\|WP_080041853.1\|7331546_7331834_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	5.33563e-05
NZ_CP017717.1\|WP_080041855.1\|7332269_7333805_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	2.20543e-96
NZ_CP017717.1\|WP_080041860.1\|7338131_7339265_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	1.79266e-175
NZ_CP017717.1\|WP_155129894.1\|7320066_7320720_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.46784e-77
NZ_CP017717.1\|WP_080041856.1\|7333863_7335567_-\|glyoxylate-carboligase	gnl\|CDD\|183066	PRK11269, PRK11269, glyoxylate carboligase; Provisional.	0
NZ_CP017717.1\|WP_080041852.1\|7328516_7329809_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	3.94838e-26
NZ_CP017717.1\|WP_080047115.1\|7314738_7317375_-\|pyruvate,-phosphate-dikinase	gnl\|CDD\|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NZ_CP017717.1\|WP_080041859.1\|7337246_7338131_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	2.00393e-180
NZ_CP017717.1\|WP_080041851.1\|7324916_7328027_-\|zinc-carboxypeptidase	gnl\|CDD\|349432	cd03859, M14_CPT, Peptidase M14 Carboxypeptidase T subfamily. Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT has moderate similarity to CPA and CPB, and exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues like CPA and C-terminal positively charged residues like CPB. CPA and CPB are M14 family peptidases but do not belong to this CPT group. The substrate specificity difference between CPT and CPA and CPB is ascribed to a few amino acid substitutions at the substrate-binding pocket while the spatial organization of the binding site remains the same as in all Zn-CPs. CPT has increased thermal stability in presence of Ca2+ ions, and two disulfide bridges which give an additional stabilization factor.	2.71254e-94
NZ_CP017717.1\|WP_080041849.1\|7322531_7323509_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	9.02316e-32
NZ_CP017717.1\|WP_080041857.1\|7335581_7336442_-\|2-hydroxy-3-oxopropionate-reductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	4.44054e-101

>NZ_CP017717.1|WP_080041852.1|7328516_7329809_+|IS110-family-transposase
MDEVEEHERLFERVAGIDIAKSEVKVCVRVPGSRVGYRRQEVRTFPAVTAELLALGDWLRIEQVQLVVMEATGTYWKPVFYALEDDFECWLLNAKQVKHLPGRPKTDREDAIWLAKVAERGMARPSFVPPKPIRHLRDLTRYRRSLTQERTREKQRVQGVLEDAQVKLSSVISDIHGASGRAMLEAMIAGQRNPRELAQLARGSMRGKKDVLIEALRGHFSDHHAFICRMMLDNIDRLSVQIDALTRQIEQAIAPYQPQVEQLDEVTGIGPIAAQDIVAEIGVDMSRFATASHLVSWARFCPQTTQSGGKQPRGGATGKGNPWLGAALGEIASSARRTPTFLGARYRRLARRRGAKRALVATAHSVLIIIWHLLSDPEAHYQDLGPDHYDSRINTDRKTRQLARHLEALTGQKITIEDGKITAIGPDYST
>NZ_CP017717.1|WP_080041851.1|7324916_7328027_-|zinc-carboxypeptidase
MKRTLIMLASTLLLLGSFAIPPASAKPKPAAGQDGVFVYTGELTADQLAKLMAAGVDREEMRVVKRADGKVTIEVILASTLADSLAKQGVALKAQRASAAKLAQKGDGVFKKYAGAGGIREEIIAAANAKPGIAKVVNIGNSLNGTPITAIKVTKDARSLPDGRRPAMLYMAAQHAREWITPEMIRRLLHHYLDGYGSNAELTQLVNTTELWFMPVANPDGYDYTFTPDNRLWRKNLRDNDGDGQITGNDGVDLNRNFAYKWRYDDEGSSSLFSSQTYRGASAQSEPETVAFDNLTKRVKFSYLLNYHSAAMLLLYGIGWQQATPSPDDLIFEAMLGDDAHPAVPGYDPDIGAELYTTNGETDGHMTNLRGVMSITPEMSTCEDAVQRDPNDEWTLDDCTGGLGFTFPDSEALIQDEFLRNVPLAVAAAKTVHTPDKPVSVVGRTVPDFRPDSFSVSYGDPQPVAVIARRSLGAKALRYRINGGPTQTRSVSEWKGGERYGGENDLYFAEYRGTVSGAKPGDKVEVWFTGWKAGTGTVSSSRFTYTLAKNSKAKVLVLANEDYTGFNHGSTGTATAPKYTATYQQALKAAGYGSETWDVDAQGVPHHLGVLSHFKGVVWELGDNRLSMDQQDVVTVTPLGDLPDADVKRSQQDLTISVRDYLNEGGKLVYTGETAAYYGILDTIIGGIYYGLDGAPDTDCVVTTVQGLFDECLLLADDFTQYYMGVAGRIPRANPSGFTGAGPLAGANGTFGGPALAANPLNEAGVLQPMGTDFPRFTGTPAADYQLGTPGPFDPIEGQWYVAGPHADDSYMRLTRTINLGSVTAAQQPQLAFQLSYDTEPGYDNVIVEAHTVGQDDWTTLPDLNGRTDTGVPTECEAGFLLAEHPWLLHYLTAGNPCTGTGTSGSWNRFTGNSGGWQQVAFDLSAYAGRQVEVSISYVTDPGTGGVGAFVDDTRLLVGGTATESEGFETGLGAWAIPGPPAGSPTGAGDFVRDQADTTAGVATKDTVLLGFGLEQVGSAAERSATLRKALRYLIG
>NZ_CP017717.1|WP_080041850.1|7323505_7324702_-|MoxR-family-ATPase
MTWVPSRYEGRGIHAYITFRSYVARRRRAAHDRRRRLRRPRADRSGAARGRGRLPPRERAAVSDPALLERALFEVKRVIVGQDHMVERLLVAVLAKGHCLLEGVPGIAKTLAAETTATVVGGTFARVQFTPDLVPSDIVGTRIYRPSTESFDVELGPVMVNLLLADEINRAPAKVQSALLEIMAERQVSIGGVTYEVPAPFLVLATQNPIESEGVYHLPEAQRDRFLMKIDVGYPSESEELAIVYRMSVDPPAPAPVLDPERVVALQRRAEQVFVHHAVAEYAVRLVYATRDPERYGVAEVGRLLAFGASPRATLGLLAAGRALALLRGRDYVLPEDVRDLAHDVMAHRLVLSFDALADGVQPRQIVDRVLAAVPLPVIAPSQEAQPYDEGRRQDQVA
>NZ_CP017717.1|WP_080041849.1|7322531_7323509_-|DUF58-domain-containing-protein
MKPYLIAEPALRRLELTITRRLDGLLQGEHLGLVPGPGSEPAESRPYRVGDDVRRMDWNVTARTNEPHVRDLVADRELEVWALLDATASMDFGTAAMEKRELALAALAAVGFLTQRTGNRIGTHLLHGGGVRTLPARTGRPHLMALLQAAFALPRTPPGVAEPLLGVAAEQLGRVVRRRGLVVVVSDFLDTPETWEPPLRRLTARHQVLAVEVLDPRELTLPDVGILTLIDPETGRRREVATGNARLRRRYAEAAAGQRDAITGALRRAGAGHLRLRTDRDWVRDLVQHVMRRRRLAALAPGHRAPGHQAPGHGAPVTGGGGDVA
>NZ_CP017717.1|WP_080041848.1|7321590_7322535_-|VWA-domain-containing-protein
MTLLAPVWLLLLIPVALLALTYVIMAVRSRTAYAVRFTNLDLLDKVAPRRPGWRRHVPAAALLLMFALLVVGFARPTAEVRVPRERATIMVAFDVSASMGATDVAPNRFEAAKQAARQFVEGLPERFNLGLVSFSSAASVAVPPTTDRPAVLAALDRLSMDSGTAIGEAVFSSLEAIAALDAEEERPPAHIVLLSDGSSTTGRTVSAAAAEASARGVPVTTIAYGTPGGTISLSGRDVPVPVDGPALRDLAESAGGGFYEAASGDELQAVYEDIGTSVGYRTERQEVWQWFVGAGLILALIAAVTSMVWFSRLP
>NZ_CP017717.1|WP_080047116.1|7320742_7321675_-|trypsin-like-serine-protease
MAVVRGGGADPRVDRGGDVDGVVLEAAVRGLGAPRGPAFLTPPINVTQAGGGGAVPKTAVPPPPRGGRILAAAALVAALTGAAAGTAGAVGARLLGGPEPAPAAALPRVAPAPSASLTGLSATAARVLPSVVSVETRSAGGSGFVVDGSGHILTNAHVVRGSGTVTVVLHDGSRLTARVAGADDDEDLAVLEVDHPGELTPATLGRSSELSVGDQVLAIGSPLGLSGTVTSGIVSALDREVRLGGSRRTAVQTDASINPGNSGGPLVNARGEVVGVNTAIAASRGGGNIGIGFAIPIDRAAPIAERIIRN
>NZ_CP017717.1|WP_155129894.1|7320066_7320720_-|response-regulator-transcription-factor
MVEDEEDLVDALRVGLVRAGYAVDVAYDAPSAHEKLQVNTYDLVLLDLNLPGGDGFQLCRTVRAAGKGVRIIMVTARDRLDDRVRGLDEGADDYLVKPFAFPELLARVRALLRRDTGGGTSVLEVGGLRIDTARLEVSLDGRSLALTPKEYGVLHYLMTRPGHVVSTEELLEHVWDEHADPFTSTVRVTVGNLRRKLQEDGLIETVISRGYRLKEPT
>NZ_CP017717.1|WP_080041846.1|7317475_7318969_+|cytochrome-bc-complex-cytochrome-b-subunit
MTGLIQLYDHLTENWIRPIGLHQFLRKAGGRCRIGSHPHQEAPMATPTKPKWRPRIIVGSAKAAVDSAIYLDDRLPFGRWLRPQLRKLFPSHWSFLLGELALYAFVMLVLTGTFLTLFYKPNPDVAYESAVELSLQVRGGLLVRQLHHWSATVFVLAIVAHLCRVFFTGAFRRPRELTWMLGVLLFGLVLFESFLGVSLPGDQLALAGLRQAQGVLLSVPLVGTYLSAFVFDGGFPGQVIPRLFALHVLLIPGILLAVVPLHALILTWRQKHTERRATAAGEHQVSGGPFFPYFAVKNGATALFTIGFLALLATFVRVNPVWEHGAYRPGAPPPSAQPFWYFGVLDGAQRLVPAWELPIGGYVLQPGLWIPPLILLAFFGVLFLYPFIERRYSGDRDVHHLLDRPSQAPVRTALGVAVITFFTTLWAGTWVSVAPPAMHSAPGLPAPPPAPPTLLTVPPDTYALVVGGLRVAVFVLPVVAFLLTRAICRRRSAAATA
>NZ_CP017717.1|WP_080047115.1|7314738_7317375_-|pyruvate,-phosphate-dikinase
MAKYVYDFTEGNRNLKDLLGGKGANLAEMTNLGLPVPHGFTITTEACRHYLAEGSVPSGLDQEVAEHLEALEAKMGRKLGQADDPLLVSVRSGAKFSMPGMMETVLNIGLNDESVHGLAKQSGGNDRFAWDSYRRLIQMFGKTVLGIDGDLFERALDDLKGRRHDTDLDSGELQQLVETYKGIVRDQTGKDFPADPREQMRLAVMAVFDSWNAPRAILYRRQERIPADLGTAVNIMAMVFGNYGNDSGTGVAFTRDPGSGQQGIYGDYLQNAQGEDVVAGIRNTIPLQDLEHLDKPSYDQLVDIMETLENHYRDLCDIEFTIERGKLWMLQTRVGKRTAAAAFCIATQLVDQGLITMDEAVTRVTGDQLAQLMFPRFDGGADKKKIAKGMNASPGAAVGKAVFSSERAVELAGQGEDVILVRRETNPDDLAGMIAARGILTSRGGKTSHAAVVARGMGKTCVCGAEDLDVQTAERRFTAPGGVVVSEGDVISIDGTSGEVYLGEVPVVDSAVVEYFEGATEPQDDLVKAVDRIMRHADAKRRLGVRANADTPEDAARARRFGAQGIGLCRTEHMFLGERRQLVEDLVLASSDEERQAALDALEPLQKSDFIGIFQAMQGAPVTIRLIDPPLHEFLPDIVDLSVKVATGAATDKDRKLLTAVKRLHEQNPMLGLRGVRLGLIIPGLFAMQVRAIAQAAAEVPGARPEIMIPLVAAVQELESVREEAVKILADAGVDALIGTMIEVPRAALTAAQIAEAAEFFSFGTNDLTQMAWGFSRDDVEAAFFSRYLDLGIFGVSPFETLDREGVGRLMEIAVREGRQARPDLHLGICGEHGGDPDSVHFCHDVGLDYVSCSPFRIPVARLEAGRAALTETDSDTR
>NZ_CP017717.1|WP_080041845.1|7313767_7314184_+|hypothetical-protein
MHWHAYTWTGAGADRGNEAERRTTSPDFTSSALPPMRTGDWLAKPAARIAATVDDVREAAEWLAAEYGKIRAALRSPERILLDDRLATALELLSGGVDVQWGEWLQDGRFSSIAMICCPNKHVSHRCPAGRLAQAGAR
>NZ_CP017717.1|WP_080047117.1|7330066_7331431_-|glycine--tRNA-ligase
MDTIVSLAKRRGLVYPSSEIYGGLRASWDYGPLGVELKNNVKRQWWLSMVQSRDDVVGLDSCVILAPEVWRASGHVETFTDPLTECLSCHKRFRADHLIEAYEEKNAKSPEGGLTDITCPNCGNKGTFTEPRQFSGLLKTYLGPVEDESGLAYLRPETAQGIFINYLNVQQSARKKIPFGIGQQGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGTDEEWHQYWIDERFRWYSDLGINKDNLRLYEHPKDKLSHYSKRTVDIEYRFNFAGSEWGELEGIANRTDFDLTSHSKASGVDLSFFEQESGERYVPYVIEPAAGVDRATLTFLLDAYTEDEAPNAKGVMEKRTVMRLDHRLAPVKAAVLPLSRNADLSPKARDLAAQLRRRWNVEFDDAGAIGRRYRRQDEIGTPFCITVDFDTLEDQAVTIRERDTMAQERISIDAVESYLRQHLND
>NZ_CP017717.1|WP_080041853.1|7331546_7331834_-|antibiotic-biosynthesis-monooxygenase
MLAVIRYTVPESQSQDFVKQGHAILDTFAGQPGYQRGRLARSVDEPNLWALVTEWEGAGFYRRALSAARMVMYPLMILMLNEPSAFEDVYTRDEA
>NZ_CP017717.1|WP_080041854.1|7331916_7332273_+|hypothetical-protein
MAPDNKRPQGGRQPQGEQFFTPGATGLRKAVERRSAVPMTFLFTQVPRWVAPALLVILLLVGFAVANPLGGVAVLPVLAFVGWLAYLSWPSLGVGGKVLRVAMLTFLVLLVATRFGAF
>NZ_CP017717.1|WP_080041855.1|7332269_7333805_-|aldehyde-dehydrogenase-family-protein
MDMRLKPGTSWQDAYERCCSAAPEAFHDDRVLNHWGGIWHRDGRPVPGFSPLDGTAIAGLPRLDRAGAGRAVAGAVEEHQRWRHLPLAERKAMVAAAVEAMAAHRDLLALLLVWEIGKPWKTACADVDRCLDGVRWYIDEIDRMVDGRTPLPGPVSNIASWNYPMSVLMHAMLVQALAGNAVIAKTPTDGGLCCLTLACALAVREGLPFTLVSGGGAELSPVLVGSGSLGCVSFVGGRDAGGKVATSLADLGRRHVLEQEGLNCWGVWEYGDWDLLARQLRGSFDYAKQRCTAYPRFVVQRALFHDFLAAYLEAVGSLRFGHPLAVADPDDPLPALDFGPLINASKAKELADQVDEAITRGGVPIHRASLDSGHFLPGQDTSAYFAPTALLNPPPSSPLHHAEPFGPVDTIVLVDTEAELLAAMNASNGALVATLSCESEETFARLAPEVRAFKVGHNRPRSRGDREELFGGLGASWRGAFVGGDLLVRAATTGQDGERLPGNFPSYTLLP
>NZ_CP017717.1|WP_080041856.1|7333863_7335567_-|glyoxylate-carboligase
MEAVVKVLESEGVDTVFGIPGAAILPLYAALRNSSIRHITVRHEEGGTHAADGWARVTGNVGVCIGTSGPAGTNMITGLYTALADSIPMICVTGQAVTSKLHQEAFQAVDIVEIAKPVTKWAVQLKEPAQAPWVFREAFRIARSGRPGPVLIDLPLDVARGSCRYDPDLDAPLPVEVPKPLPKAVRAAMDLLEEARRPIILAGGGVIIGDATGELRALAEHLQVPVQVTLMGKGAFPEDHPLFAGMAGTQTQTRWGNAAFLESDLVLAVGARFGDRHTGDLDVYRRGRTFVHVDIDPLQIGRVFEPDLGVLGHARPVLAELRDEARRRGGPREPGKWPRRVAELRGTMGRRDDFDDVPIKPPRVFREINEYFPRDTTFVTAIGLYQIWSGQFQTTYLPRRYLVCGQAGPLGWEVPAAMGVKLAHPERQVVAVVGDYSFQFLMEEVAVAAQYRVPFVIVMINNEYLGLIRQAELPYGMNYAVDLHYGEGGIDHVKAMEAFGCPARRVELPGDIRDALAWASAEAASKRLPVLVEVMVEREANAAMGPSLEAVKEFEPLPELITADWSD
>NZ_CP017717.1|WP_080041857.1|7335581_7336442_-|2-hydroxy-3-oxopropionate-reductase
MNIGFVGLGIMGSPMAANLLKAGYVVTGYDVSAERLEQLTALGGKAATGVVDAVAGADVVITMLPDSPQVEEVAPLVIEYGKPNLLYIDMSTIKPETSRWVARQAAAVGVRALDAPVSGGERGAIDGTLSIMVGGAPEDVEAARPVLDRLGVTVVHVGPAGAGQTVKAANQLVVGGIYGLVSEAIVLLEASGVDPAPGLDVLAGGLAGSRILELKRHTMVKREFAPGFRIDLHHKDMGIALAAAREAGVSLPLTGQVAQLVAAARAQGHGALDHSALLKVIERLNA
>NZ_CP017717.1|WP_080041858.1|7336470_7337250_-|TIM-barrel-protein
MRTGALRFDVNLSILFTGLPLLERPAAAAKCGFDAVELWWPFDSPDPGGAALAELRQAVEDAGVRLVGLNFDAGDMAAGERGLLARPEGSARFQANIDVAVQLAGELGCPVLNALYGNGPGTDRELAVANLRRAADAARTIGATVVVEALNSHENPLYPITSAGAAFDLIDQVDRDNVAFLADLYHLHRMGENVLALIDRHAGRFGHVQIADDPGRGRPGSGGMPYEEIFARLEAAGYRGHVGLEYRHEGPGAFDWRQG
>NZ_CP017717.1|WP_080041859.1|7337246_7338131_-|succinate--CoA-ligase-subunit-alpha
MAIFLTKDSRVLVQGMTGAEGTRHTARMLAAGTDIVAGVTPGKGGRCVDFGEREVPVFGSVAEAVSETGADVSVIFVPPRFTAAAVEEAVQAEVPLCVVITEGVPVHDAVRFRALANGRTRIIGPNCPGLISPGQSSAGIIPADITSAGRIGLVSKSGTLTYQLMYELRDLGFSTAVGIGGDPVIGTTHIDCLRAFQDDPGTDAIVMIGEIGGDAEERAAAYIAANVTKPVVAYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAVGVRVGRTPSETARLMRSVLSRAAT
>NZ_CP017717.1|WP_080041860.1|7338131_7339265_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLYEYQAKELFGRHGIPVPAGRTAATPAEAREIAAGLGAPVVIKAQVKTGGRGKAGGIRPAAGPVAAEAEADRVIGMDIKGHIARRVLVEAATVPFEEYYAAFLVDRAEGGFLAMVSSQGGMEIEELAATDPDALVKLPIDPVTGVDADTAKLLAAKAGLPEQAAPVLEKLWRVLVAEDALLVEVNPLICTTDQRIVALDGKVTLDDNAAFRHGWDDYGERTDSLEDRARAKGLNYVKLDGTVGVIGNGAGLVMSTLDVVAGAGAGPANFLDIGGGASAQVMADGLEIILADPDVRSVLVNVFGGITACDAVANGIVTALELLGERGHRRPIVVRLDGNNAEVGRRILSDARHPAVRQVATMDGAAEMAARLAAGA
>NZ_CP017717.1|WP_155128360.1|7339355_7340594_+|MFS-transporter
MENAVKDWRGRSYRPGPVPADRTRMFRLALAAMAAISPLQYGYAALHARQASGLTLLAIWIACQAAGALPALHLVRRRRLGVRACLAAGAALSGLGLLAAGLTPTGAPALIGYAVLGGLGAGLVYGVCGEVVSSWYPERPAARVGLITGAFGYGAVPLLLWAGIAPGTTPAAFLVCAALATAVIATAARHLRLPPAQWWPDDVDPRTHALDAARLRTSPEAVKQFGLAQALRTRTLPALALMLVCAGAVSVFDVIAVASTGAWGALALLVALNGAGRSVAMRAADRYGRRRVLAAVFSALAAGQVLLAVAVQSAVGSPLLWLGAVAAGLGGGAFYPLLASLVRELFGTERATEIHAVVYSAKAVAGGLAVALALTALTAPGAALLAAAALAALPALATPRLRIPGLPATIPL

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Crispr_ID: NZ_CP017717_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_17

7470445-7470534

Orphan

Consensus_repeat	Method
GCCGGTTGCCAGGCGATCGCGATCAGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_17

>merge|NZ_CP017717|17|7470445-7470534|CRISPRCasFinder
GCCGGTTGCCAGGCGATCGCGATCAGGTCGGCGGCACGGGCTCCGGCCGCCGGTCGGAGGCCGCCGGTTGCCAGGCGATCGCGACCAGGT

>NZ_CP017717|17|15|7470445-7470534|CRISPRCasFinder
GCCGGTTGCCAGGCGATCGCGATCAGGT	CGGCGGCACGGGCTCCGGCCGCCGGTCGGAGGCC
GCCGGTTGCCAGGCGATCGCGACCAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080041966.1\|7469725_7470418_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP017717.1\|WP_080041961.1\|7461597_7462584_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119353
NZ_CP017717.1\|WP_080041964.1\|7466239_7468816_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041963.1\|7463186_7466243_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NZ_CP017717.1\|WP_080041962.1\|7462693_7462966_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|178943
NZ_CP017717.1\|WP_080041968.1\|7473228_7473687_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367797
NZ_CP017717.1\|WP_155128382.1\|7456659_7457385_+\|heme-ABC-exporter-ATP-binding-protein-CcmA	unknown	unknown	gnl\|CDD\|224054
NZ_CP017717.1\|WP_080041967.1\|7471725_7472211_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP017717.1\|WP_080041958.1\|7457578_7459159_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080041965.1\|7468812_7469733_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP017717.1\|WP_080041970.1\|7475102_7476332_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP017717.1\|WP_080041959.1\|7459179_7459671_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP017717.1\|WP_080047136.1\|7480025_7481600_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225212
NZ_CP017717.1\|WP_080041974.1\|7485620_7486694_-\|DegV-family-EDD-domain-containing-protein	unknown	unknown	gnl\|CDD\|273257
NZ_CP017717.1\|WP_080041972.1\|7477369_7479076_-\|tryptophan-2-C-methyltransferase	unknown	unknown	gnl\|CDD\|275221
NZ_CP017717.1\|WP_080041969.1\|7473696_7475100_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP017717.1\|WP_155128384.1\|7459711_7461541_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP017717.1\|WP_080047135.1\|7472214_7473186_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
NZ_CP017717.1\|WP_080041971.1\|7476353_7477367_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|227940
NZ_CP017717.1\|WP_155128388.1\|7483781_7484249_-\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080041966.1\|7469725_7470418_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.48095e-103
NZ_CP017717.1\|WP_080041961.1\|7461597_7462584_+\|hypothetical-protein	gnl\|CDD\|119353	cd02874, GH18_CFLE_spore_hydrolase, Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.	2.6112e-08
NZ_CP017717.1\|WP_080041963.1\|7463186_7466243_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.82177e-07
NZ_CP017717.1\|WP_080041962.1\|7462693_7462966_+\|30S-ribosomal-protein-S20	gnl\|CDD\|178943	PRK00239, rpsT, 30S ribosomal protein S20; Reviewed.	8.52492e-22
NZ_CP017717.1\|WP_080041968.1\|7473228_7473687_-\|hypothetical-protein	gnl\|CDD\|367797	pfam04073, tRNA_edit, Aminoacyl-tRNA editing domain. This domain is found either on its own or in association with the tRNA synthetase class II core domain (pfam00587). It is involved in the tRNA editing of mis-charged tRNAs including Cys-tRNA(Pro), Cys-tRNA(Cys), Ala-tRNA(Pro). The structure of this domain shows a novel fold.	1.26836e-21
NZ_CP017717.1\|WP_155128382.1\|7456659_7457385_+\|heme-ABC-exporter-ATP-binding-protein-CcmA	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.14809e-56
NZ_CP017717.1\|WP_080041967.1\|7471725_7472211_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.78801e-15
NZ_CP017717.1\|WP_155128384.1\|7459711_7461541_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP017717.1\|WP_080041965.1\|7468812_7469733_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	3.48587e-94
NZ_CP017717.1\|WP_080041970.1\|7475102_7476332_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.28569e-56
NZ_CP017717.1\|WP_080041959.1\|7459179_7459671_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.23776e-26
NZ_CP017717.1\|WP_080047136.1\|7480025_7481600_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	1.06275e-44
NZ_CP017717.1\|WP_080041974.1\|7485620_7486694_-\|DegV-family-EDD-domain-containing-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	1.25737e-78
NZ_CP017717.1\|WP_080041972.1\|7477369_7479076_-\|tryptophan-2-C-methyltransferase	gnl\|CDD\|275221	TIGR04428, hypothetical_protein_AATC3_27493, tryptophan 2-C-methyltransferase. Members of this family are the B12-binding domain/radical SAM domain enzyme tryptophan methyltransferase, named TsrT in the cassette for thiostrepton biosynthesis. Thiostrepton and related thiopeptides are synthesized by extensive modification of a ribosomally translated product, but this enzyme is involved in a pathway that converts a free Trp residue to a quinaldic acid moiety before it is appended. [Cellular processes, Toxin production and resistance].	0
NZ_CP017717.1\|WP_080041969.1\|7473696_7475100_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	1.98198e-124
NZ_CP017717.1\|WP_080047135.1\|7472214_7473186_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	8.27761e-92
NZ_CP017717.1\|WP_080041971.1\|7476353_7477367_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|227940	COG5653, COG5653, Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane].	0.000153423
NZ_CP017717.1\|WP_155128388.1\|7483781_7484249_-\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	1.50423e-23

>NZ_CP017717.1|WP_080041966.1|7469725_7470418_+|ABC-transporter-ATP-binding-protein
MTDAPLVVVEGLRKVYRSGPKEVVALRDVSFSVRAGELVAVRGRSGSGKTTLLNQIGGLDRPDAGRVVVDGREITSLPEDELLAVRRDVIGFVFQSFGLIPVLSAAENVGVPMRLRRTPVAEREARVRMLLALVGLEQHVNQRPYELSGGQRQRVAIARSLANRPRLLVADEPTGQLDSQTGRQIMELLRAVVRSEGVTALVATHDPSLMTLADRVLEISDGVVREAALT
>NZ_CP017717.1|WP_080041965.1|7468812_7469733_+|ABC-transporter-ATP-binding-protein
MNPTLSELEAKATRPSAAFGGDAHIVCDNLVRIYKTEGVEVVALQGLDLVIDKGELVAIVGASGSGKSTLLNVLSGLDVPTAGVARVAGMDLLSMSAKDRLRYRRSVVGFIWQQTARNLLPYLTARENVELPMKLAGAARKGCAMELLELLGVASCAGRRTPEMSGGEQQRVAIAVALANSPQLILADEPTGELDSETSEQVFDALRTANRELGVTVVIVTHDPLVSEQVDRTVGIRDGRTSSETLRREGAEGQIIAEEYAVLDRVGRLQLPRDFMNALHMERRVRLELESDHIGVWPAREEPSND
>NZ_CP017717.1|WP_080041964.1|7466239_7468816_+|hypothetical-protein
MRTWLLARVHLGTVAVLFVLTLSACVLVAGLPRAAQSSYDEALRRALTAAPAVQADLTVATQSSGRPEDLRERAQFDSRERLWREIVPAGLRPLTTGAGHMSAKTELTPVTGTSGSMYVNLGWLSDADRRVDWVQGRAPGAPTTTRYEGGTIPVFEVGIVEEALPEMGLRLGQTITLGENDYAAVKIVGAFRAKDPGDRSWSHDADVLHVIEQQPPGGKDHVKHITTLMSDAGLTALSGEGRNLTYRWVLPLDARAADAMDVPGLRAAVVEFERVVGLQTTGSPYRVETALPKLLGDFLAALSTAQTVMYLVLGGLLAVALGVIVLAVQLLADKLEHPLGLARARGGSLRQVAGTAAALAGLAVVPGALAGYALSYLVPGPVLPIVHAGPVVVVVVALAYAGARTALTHRAPLHERRDDVATARPSARRVTLEVLVVVLALAGAYLLRARGLSAAGGQDPFLLVVPVALTIAAALITLRCYPYPLRLLVRLAARGRAAVPFLGLTRASRARSGSLLPVLILLPALGVSVFAAVVSDGIATTQRTASWQQVGAPVRVTSESEIPAEAIERVRRLAGVERVVPAQTGRVQVGYGAERADAIAVDVTQWRDLLDGAPVGLPPLSDGALVSPELRGRGTIEIGWQSRVKLATRGVIESVPGFYTHGKFMVVPIGVQVRPAVNTLLIQGDVALPELARLVPSAVVTSQESALRAIQDDPLTATVRWTLVIVTVALAAYALIAVVLSLVIGAADRARAVSFLRTLGLSERQAQRLTVLEILPMILLTALVGLGLGLGLPAALGPGVDLSSYAGDLPVGDYSPGLLLPGALAAGLAGVAVLGAYAHTAISRRRSLGAVLRVGELP
>NZ_CP017717.1|WP_080041963.1|7463186_7466243_+|ABC-transporter-permease
MRGPLIVKRAFSEPLLLLAALGSILLATTTLVALTMYASSIAEAGVRRTMETASYSQTVATISSPVTAETFPRFDQAVRAELTRAYAGPPALTTSFRSDSYAMPGQEGRERPDLLRFGSYDGLDRHAKLVAGAWPKPGDDPVEVAISLSASSASGFEVGQEFTTRGRLDPRPVRVRVAGVFQIDDPFGERWAGEQLLSRGVERGDFTTFGPLMVTRETFLARFATSVNATWTAVPDLRTLTPERLRPLAGAIGQVEERLKAAGCGSCVAASRLPDLLTQLGTASLVARSTMLIPVLQLLLLAAYALMLTARLLADHRRMEVALLRSRGAGTVRLAALAGGEALLVALPCAVVAPFLGPPLLALVNALPWIKASGVRLAPVADAGTFLVSFGVALAAAVLLVLPALAGARRTYVEEQSARGRGGGRGLIERAGADLALLVVAGLAIWQLQRYGAPVTATAAGGLGIDPLIISGPALALLTGGMLGLRLVPRLSRLAERITSRRPTLAPALGAWQVSRRPLKYAGPALLLTMAIAIGIVSLATAATWRSSQLDQARHQAGADLRLSGPADGPELGALGRGTAFTALPGVTAASPGFRGQTDVSGTNAMLLALDASKLGELFHLRSDLSEQSVGELSKALAGERAAGLALPGRPAGLVVTAEASTELPARLVLSDGLGVWRDVPLGLLKKGTNRVEVDLRALAGRSGTITYPLTLLGLVASAQEDSTGSLTVTALSADGQQVAAPPLTMSVSGTSAAPFVRRSEPGPLPVVLTSDLSAALKLGTGQTGRASIDRRVMTVKVVGVVETMPTTPAGQQALLVDWQTMQAHELAAAQLPRPATEWWLAAGDTAPAVAALGGHPEWDVTALDQRALAAALRDDPLASGLQGALMLGFGAALVFAVLGFLVNAAVAARERLAEFAILRALGVSSRQMLGMLAVEQAFVVGLSLVAGTALAVVVGVLVVPHIVLTGQAAAVTPGVVLDIPWTATGVMLALVAAVLFAIVAGLARHLRRQGHGLREEQ
>NZ_CP017717.1|WP_080041962.1|7462693_7462966_+|30S-ribosomal-protein-S20
MANIKSQIKRNKQNEKARLRNKAVKSSLKTAVRKFREAAEQGDVEQATALQRAAARQLDKAVSKGVIHKNQAANRKSAIAKQAAALAAAK
>NZ_CP017717.1|WP_080041961.1|7461597_7462584_+|hypothetical-protein
MIARTVIRRGLRLLALALAIAVALGGLLAAALRIQFTGAPAAWAKSTGNDALWLGHAWVDGRRTEQDVERLAVRLRATGIKDLYVHSGPFEWDGRLDPAKYPNAGNFVQWVRKHLPGLRVSAWLGQAVKNGLDLDDPQARENVLAGVAAIMKQGYDGIHYNFEPIGDGDTAFLDLLDRTRRHTKLLSTSTPQIEPYLGMRLTARAVLGHDKYWSEGYFRQVVARVDQVAIMTYDSFTPAQSLYGGYVARQAALALDLVPESKALYIGAPAYHDHGIAWADEAESVAMAAEGARLALTEHGRRERFGLALYVDFAATEEDWREYMTRWR
>NZ_CP017717.1|WP_155128384.1|7459711_7461541_-|elongation-factor-4
MRTQPGQTDPALIRNFCIIAHIDHGKSTLADRMLQITGVVEERAMRAQYLDRMDIERERGITIKSQAVRLPWDGHVLNMIDTPGHVDFTYEVSRSLQACEGAILLVDAAQGIEAQTLANLYLAMNADLHIIPVLNKIDLPAAQPEKFAEELAGLIGCDPSDVLKVSGKTGEGVRELLDHVVATVPAPVGVADAAARALIFDSVYDTYRGVVTYVRVVDGHLGKRERILMMSTNATHETLEIGVISPEPKPAELGLGVGEVGYLITGVKDVRQSRVGDTVTSAGKPAQEMLAGYEHPKPMVFSGLYPIDGDEYPELREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHMEIVRERLEREFGLSLISTAPNVVYRVVMEDGKELTVTNPSEFPTGGKIAQVFEPVTKSTILAPAEFIGAIMEICQGRRGQLLGMDYLSEDRVEIRYTLPLGEIIFDFFDQLKSRTRGYASLDYEPAGEQEADLVKVDILLQGEAVDAFSAIVHKDKAYGYGVDMAKKLRELIPRQQFEVPIQAAIGARVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFVAALSTDSSADKTKK
>NZ_CP017717.1|WP_080041959.1|7459179_7459671_-|GNAT-family-N-acetyltransferase
METVQTARLVLSRVMPEDLDAVHEIHSDPRTSVYHPSGPVTDLESSRAMLDLWLADWDERGLGYWAARLPGDPHVLGFGGLRHAVVDGAEVLNLYYRFRPSAWGHGYAVELARAALRVGKGLGTVVAVIRDVNLPSHRVAERAGMRKDRTIPYGGVPSDVYVA
>NZ_CP017717.1|WP_080041958.1|7457578_7459159_+|hypothetical-protein
MTGGDGVTGASGGDVRTLRAYVRSRTRTPASLMDRYVSVFCLLMLIAVAGRPVSGVLASLAVPGEPARMGAGVALLALALAGFLAAARGAGPVLLPGADASWLLLSPLNRRHVLARSARLLLGVAAVAGLLLGIGLLAVLGAPDQLVWRVLGALVVGVAAAVGGMALAVLGQASESWRVWLTGGMALLLALAVVAVTGQLRAVLAVAASAPLPTLTAAVSGAAVLSGLLVRQAWATLDRIPTRTLVTSSTRAGHVASAAMSLDPGALTWIAEDNHWRARKLASRRWPSLPAPLSLPAPFALAWQDWRRLARRRGRLAAVAGSAALPAVLAQAGGPPVVLGLAVLGGALAVASLGTSGARRDADNPALARLIGVGRRQALAARAALPALLAGTWAAVALAGLTLVSGVGAGAGVGVWANGAPIDLMVSGGAAWWWFGPLAAPALAAGALRMARRPPVDHSMPVIDTPGGAVPTGPLFWAATGPDLALLGCLPTAAALASQPTALAPFLVAQAVLSVLVLLGFLMRAE
>NZ_CP017717.1|WP_155128382.1|7456659_7457385_+|heme-ABC-exporter-ATP-binding-protein-CcmA
MAEVGGGGRSGVSGWAGERVGGCAGGGWGRYARTVYDSIIGVSALTVELGGNPVLRDLSLSVAPGEIVAVVGPNGSGKSTLLRCLAGLQPVTAGEVRVFGRAPADDAAFWGRVALLGDEPAWYPGLTAREHLELMGAVHTRARMTVDAALELFALEERADAPPLNLSTGQRQRLSLAATLLRPSTLLLLDEPERGLDKGFRAELADLLTEYADEGGTVVMATHDQGLAAIGRQIAPSGVTA
>NZ_CP017717.1|WP_080041967.1|7471725_7472211_+|MarR-family-transcriptional-regulator
MEDSVDRHLARWRGKAPFDERVEAIVTRMQFLVKHLSHTKEAALAEVGMQDYEFETLHRLVARGGSATPSELAADLLLSPAGMTGRLDTLERTGLVRRVRSASDRRRVDVELTPKGKDLWFEAMTIRAEVEAAMVNALSAADQDVLDTLLKQLLLKAEGTR
>NZ_CP017717.1|WP_080047135.1|7472214_7473186_-|DNA-polymerase-III-subunit-delta
MAGTDAAPVTLVVGDEELLAERAVSGVVAAARAADPSAEVHDLFGSKVTTGELAQLTSPSLFGDRSVVVIRSAQDLSKEVIAEIVAYTKQPSEDTVMVLSHPGGVKGKALVDGVKKAGAKVVTVSKVTKAGERLDFIKGEFKRAGRSISGDAAQALLDAVGNDLRELAAACSQLVFDTDDKTIGAAAVARYHKGRAEVTGFNVADSAVEGRLAEALEQLRWALGTGVAPVLLVSALAGGLRSLAKVGSAPRNLRGGQLASHVGMPPWKVDRVKRQLNGWGPEGLSRAIQAVASADEQVKGGGADPAYALEHTVQVIVASRTGR
>NZ_CP017717.1|WP_080041968.1|7473228_7473687_-|hypothetical-protein
MTSPEDLLRASGAPFKLHEHVPIVGRHDAETKLGLPTPMMLKTMVFRTVDGTFVLAALPVTGRVGYARLARAAGVRRDRLRQAAPEELRLLGVQPGGASPVCDADGVVIVFDASVPGMGTVYCGSGRPDRTIEIDADVLIDVVKPRLAELCQ
>NZ_CP017717.1|WP_080041969.1|7473696_7475100_-|amino-acid-permease
MDPLRHDLSRRQMRMIGIGGAIGTGLFLGSAAAIATAGPAVVVSFLIGGAVALTLAYALSTMVAAYPGVHGFGGLAHRFLGRGPAFVQRWWYWGAQVVNVGSEALAAGIYVRLWWPQLPLWVPVAVIAIVVLAANALTVRVFGEFEYWFAMIKVVAILLFIGLGVAAIFFGLPGSPAIGLSGWTDHGGFAPFGLPGIWLAMVLVFFSYMGTESMAIAAGEARDARRDVVAATRGVVVRLLLFYVLATAVVISVVPWTDAGGTVTASPFVRLFQYAGIPAAVHIMNAVVLVAAVSAMNTNVYLTSRTLYQLSVTRHAPGVFARVNRRGVPLNALLFSGLGLVLASLLAAFAPGQAFLALVGLALGGAVLTWVLILATYLAFWRAHPERRSPRGNLLAAGSALSILVLLGVLATMSVTETFATPTRLGAPLLLLVVVAAVAHRLLGRRAGPEPGPEELSPDPAAAGPAR
>NZ_CP017717.1|WP_080041970.1|7475102_7476332_-|MFS-transporter
MVKVVRAAVARGPVGKLPRLFWVLWSGTLINRAGYVVQPFLAIYLSGRWQLSPVLIGTVISTFGAGAMLSPILGGQLADRVGRRRMLIAGMLASAGTMLLIPFATHVVAIALAVGVYGLAVDLYRPAVSALVADTVAPADRSRAFGLLYWAVNLGTAVAGVAGGWLATRSFWLLFAINAVACLSFATIAARLVPADLPRPRRTTWTRFTMADGLLVSLTLAFFLCACLLVQAYVALPIVMTGQGFDSSAYGLVLAVNPVVVVVLQPLLLRRLTALPPLAVFAAAIALTGAGFGLTGLAATMPAYAATVLVWTVGEIAVAAVGPALVAEIAPPDMQGRYSGFFNAAYGAASLAGPVSSSFVLQEHGATALWTACLVTGAAGAGIAMALAPALRRRRLSLSVTEHAPEQES
>NZ_CP017717.1|WP_080041971.1|7476353_7477367_-|GNAT-family-N-acetyltransferase
MRPAPIYRDLFCQMYGVAAPAVVLGEMIHWWAIVREAGLGDQKLHRQTAYVPAGYFYATHVDAPDARTVREARERAADLATDWVLYPVVKAADDTGALRAAGFTPIPWFVGADYRVRDGVDEDLRGQLGKNRHGDLRRAARRAAERYDLELVSFPDITEEHLLLFDRLHRLNLRKYGHQHNHLSLPALRAMLRTPLGAGLHLYLRRPLEGGPPVQAGLNLVEDGGRTMSFVAQGIDHAVVPSSQNLYKAWFYEMFRRGADMGVDTFVLGRGAELNKLDMGANTFYLLENHLGPVGDRETGEVERLRQRLRAGFEEIGARLAANMAQRRAANAFELRW
>NZ_CP017717.1|WP_080041972.1|7477369_7479076_-|tryptophan-2-C-methyltransferase
MSQELVVLVNPNKLHPPITPYALDILTTSLEAAGFRVEVLDLTFRRDDWRSAVEEFFADRKPLLVGITIRNTDTIYPQEQRVFLPEHREIIQAIKAVSSAPVIAGGVGFSSMPFALVDYFGIDFGVKGPGEIIISRLAKALAGGVSPRTVPGLIINTGDGVTRVPGDGVWVSELPLRHELEGRAEFANRETAYTRRSGEPWKVDNLKYYQRGGLGNILTKNGCPFACTHCVEPDAKGNRFARRRPEKVVDEMEALTGQGVFDLHTTDSEFNLNIGNSKAILREIVRRKNADASSPLHRLRLWIYSQPAPFDEEFAELLAQAGCRGVNVAPDHVREDILKGWKVTSGGARYYTFDNTREVCRLANKYGMLTMVEVMAGMPGETWETLRECVDAMLALDATVVGFTLGIRLFPYSPLGIEFARRSAGVRTVPGVQSNTATRPITIRPIESCASVVEYERQFMFDEDGELRPLYYFSPDLPEDKETMGLPNGRWLRTVEMLWKYIPEKDHPRVMLPTAPGLTKDDNNYADNPFLTCLVQMGYKGAFWSHWRQRDEILLEAAARGLTAEVVG
>NZ_CP017717.1|WP_080047136.1|7480025_7481600_-|MBL-fold-metallo-hydrolase
MSAVRRDEMPDVARGDVSAGQRGGAPRVGPDDVSARQQGGVPRVGRGDASGQGPGDRSGIGPGGVSGARPGGVSGARPGRASGARPGGTSDAGAGGVSGMRAGKGQAGVRWLFSRPLPRWMAEAVAVPAAAQLAVTPVLVLMAGQLTPVALVANLLVAPAVAPATLLGFGAALVAPLWPDAAQVLVITAGYAVGWIIMVGRWSVGLPFATLPWPAGLPGLGLLLVTLVVAVPVLRRRAWRAVALTVVVAALVAVLVIRPVVGPWPPKGWLMVMCDVGQGDGLVVAAGPGRGVVVDAGPDPVVMDRCLRRVGVEDVPLLVLTHPHADHVDGLPGVLRGRRVGAVVVSPHRIHEGSGARVWATLARHHIPEWTVAPGTRWRFGPSELTVLAPDLARGEMSGQSEGSTINNSSVVLHVRWRAGSILLGGDLETEAQDELLHRFPVRADLLKTPHHGSNRQSPAFLASLGARAALISVGAGNDYGHPAMSTLALLRGLGLTVHRTDQSGDLAVVEREEGGMAVVSRGP
>NZ_CP017717.1|WP_155128388.1|7483781_7484249_-|ComEA-family-DNA-binding-protein
MTQIAPTPKPPPSATTAVTIHVTGKIRNPGVYRLPTGSRVADAVTAAGGVSRTASTGSLNLARRLIDGEQIVVGAPAGQQPQQPLPAADPATTVLDLNTATTDQLEQLPGVGEVLAARITEFRTNRGGFTTVDQLREVTGIGPRKFEEIKPKVRV
>NZ_CP017717.1|WP_080041974.1|7485620_7486694_-|DegV-family-EDD-domain-containing-protein
MSPLVAVVTDSTAYLGTVPGVAVVPVQVIAHAPRVAVPASGRPARTSALSPSQGPSSFARSGTNPSEPASTSTPAEPRPLAPTAPATPPNRAEGTGAGGGSGPGGGAGSGEAISIDGGSFAIDEGSFTGDLISATTSRPSPARFASCYADLAAAGATAIVSIHLSAELSGTVESALTAARTAPVPVEVIDSRSIAMGLGYPVLAAAHAAAAGASQEEVAAAARRSMRDTRTLFYVDTLDYLRRSGRIGTAASLFGSALMIKPLLHLTDGHIALLEKVRTSSRAIARLEDLAVQTAGERIVDVAVQHLAASSRAEALAERLHKRIPGLRDLRVVEVGAVIGAHVGPGMLGLTVTSANH

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Crispr_ID: NZ_CP017717_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_18

7802992-7803125

Orphan

Consensus_repeat	Method
CGACGCAGCGCGGGCGGCCACCCGGAGGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_18

>merge|NZ_CP017717|18|7802992-7803125|CRISPRCasFinder
CGGCGCAGCGCGGGCGACGACGCAGCGCGGGCGGCCACCCGGAGGCGAAGCGCCACAGCCCGCCGACGCCGCTGCCCGATCGCGCAGCGGCACAGCCGCCCAGCGACGCAGCCCGGGCGGCCACCCGGAGGCGA

>NZ_CP017717|18|16|7802992-7803125|CRISPRCasFinder
CGGCGCAGCGCGGGCGACGACGCAGCGCGGG	CGGCCACCCGGAGGCGAAGCGCCACAGCCCGCCGACGCCGCTGCCCGATCGCGCAGCGGCACAGCCGCCCAG
CGACGCAGCCCGGGCGGCCACCCGGAGGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080042222.1\|7799432_7801418_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080042225.1\|7804283_7805354_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379258
NZ_CP017717.1\|WP_080042221.1\|7798552_7799365_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080042230.1\|7809654_7809855_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235967
NZ_CP017717.1\|WP_080047165.1\|7802423_7802861_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NZ_CP017717.1\|WP_080042220.1\|7796407_7797649_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270453
NZ_CP017717.1\|WP_080042232.1\|7812060_7813656_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080042228.1\|7807330_7808530_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP017717.1\|WP_080042231.1\|7809884_7811954_-\|PASTA-domain-containing-protein	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080042216.1\|7791050_7793276_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP017717.1\|WP_080042226.1\|7805382_7806201_-\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|176450
NZ_CP017717.1\|WP_080042218.1\|7793978_7795076_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP017717.1\|WP_080042227.1\|7806237_7807242_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176237
NZ_CP017717.1\|WP_080042217.1\|7793375_7793903_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_155129924.1\|7803290_7804187_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NZ_CP017717.1\|WP_080042219.1\|7795178_7796411_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP017717.1\|WP_080042233.1\|7813704_7815105_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080042223.1\|7801464_7802427_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187538
NZ_CP017717.1\|WP_080042229.1\|7808634_7809579_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NZ_CP017717.1\|WP_080047164.1\|7797681_7798569_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080042225.1\|7804283_7805354_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	7.5154e-09
NZ_CP017717.1\|WP_080042221.1\|7798552_7799365_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.59444e-84
NZ_CP017717.1\|WP_080042230.1\|7809654_7809855_-\|hypothetical-protein	gnl\|CDD\|235967	PRK07208, PRK07208, hypothetical protein; Provisional.	0.00743154
NZ_CP017717.1\|WP_080047165.1\|7802423_7802861_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	8.6912e-35
NZ_CP017717.1\|WP_080042220.1\|7796407_7797649_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270453	cd14750, PBP2_TMBP, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose; possesses type 2 periplasmic binding fold. This group represents the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.50489e-120
NZ_CP017717.1\|WP_080042232.1\|7812060_7813656_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.62215e-72
NZ_CP017717.1\|WP_080042228.1\|7807330_7808530_-\|oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	9.84695e-67
NZ_CP017717.1\|WP_080042231.1\|7809884_7811954_-\|PASTA-domain-containing-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.15623e-67
NZ_CP017717.1\|WP_080042216.1\|7791050_7793276_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.4932e-91
NZ_CP017717.1\|WP_080042226.1\|7805382_7806201_-\|M55-family-metallopeptidase	gnl\|CDD\|176450	cd08663, DAP_dppA_1, Peptidase M55, D-aminopeptidase dipeptide-binding protein family. M55 Peptidase, D-Aminopeptidase dipeptide-binding protein (dppA; DAP dppA; EC 3.4.11.-) domain: Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel. This family also contains a number of uncharacterized putative peptidases.	1.79552e-114
NZ_CP017717.1\|WP_080042218.1\|7793978_7795076_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.95602e-39
NZ_CP017717.1\|WP_080042227.1\|7806237_7807242_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	2.64671e-152
NZ_CP017717.1\|WP_080042217.1\|7793375_7793903_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.59886e-11
NZ_CP017717.1\|WP_155129924.1\|7803290_7804187_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.89247e-88
NZ_CP017717.1\|WP_080042219.1\|7795178_7796411_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.03591e-36
NZ_CP017717.1\|WP_080042233.1\|7813704_7815105_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.67213e-73
NZ_CP017717.1\|WP_080042223.1\|7801464_7802427_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187538	cd05227, AR_SDR_e, aldehyde reductase, extended (e) SDRs. This subgroup contains aldehyde reductase of the extended SDR-type and related proteins. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.4735e-93
NZ_CP017717.1\|WP_080042229.1\|7808634_7809579_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	1.55523e-108
NZ_CP017717.1\|WP_080047164.1\|7797681_7798569_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.18757e-69

>NZ_CP017717.1|WP_080047165.1|7802423_7802861_-|MerR-family-transcriptional-regulator
MSTFTIQDVSRRSGLSEPTLRYYEDVGLIGPIPRDERSGHRRYREEDVSEVEILACLRAVGVSIEDMRTYQANRARGREAAAEQRDLLLRHARRVEAEIAAQRTRLAYLREKAALWDARDRGDAAAEAEAWRRVMEAVSALEALG
>NZ_CP017717.1|WP_080042223.1|7801464_7802427_-|NAD-dependent-epimerase/dehydratase-family-protein
MRPVLVTGGSGYLGTHLVAALLREGRPVRATVRSKDREGDLRAAVRRGGADDAGLEVVAADLMSDDGWPAAVDGCAEVHHVASPIPAVQPEDPDELIVPAREGTLRVLRAARDAGARRVVLTSSFAAVGYTPKPGAEYTEDDWTDPDTPGLAPYPRSKAIAERAAWDLMRREGGGTELVVVNPTFILGPTLTTGLGSSMQLVKAMVGGVMSVVPRQRFGIVDVRDVAELHLRVMAAPEAAGRRFLAVGDGPAWSFLEVAEVLRRRLGPLGARVPTEEAPGEEPPRPVIHNDRARGTGWRPRDAETTIVESAESLRDLGLL
>NZ_CP017717.1|WP_080042222.1|7799432_7801418_+|hypothetical-protein
MRTWFEPEETAPYAAAKAVLTRRCLAWADAHGRPADGPLVAAALDARHHSRDGRLAYWDEPQIRRYLLAWVPKYVVTPRDILEIAPEILRTFLHYLAATGLRDPRGATPAQADDAVTRVLPDFRKALDDPHLQGPATFWTQTALDHGSDLAGPGALRDFELDLDAGRIRYDRDLLGRLLEARHSRTDLDLEEERAFPQPPIALPAPDDLADAAARSVTVRRLTTLATWAGELGRPLTRSGHLTLADARELSALLGTGEQELQVRGSADLPQLRLLLAWARRLGLVRVAKGRLLQARSATLAHDPAALWARAFDVLPELGAEISMSGRAGVLGRCFAAVLPDLLATLYGMDDVPVARLEETVWPACQEHVSMETTSERTKDLWRRRTALDLERAFDVLADLGAVDLTHGPADDRYTSDLDDGALPPEAAERLRERLASPDLLLARLTPLALRSVRDRLLREGRDAPLIGELATAPPAELLGVLTQHYPPRAAAVELNAWLSHPGQDLEALLRAARDCPFRTRAAAMLAVLAQALPEGQALVRDLRHDPVLAPTALTLLVDAGEIDPAALDRREHLLLGAENFLSLLELGGPAVVIEQLRSMAGHGAHDLAAALLDSGHHDLAGLEELRELVARPLRASRDRPLRLIPGTGRGTRPLRRRRRP
>NZ_CP017717.1|WP_080042221.1|7798552_7799365_+|carbohydrate-ABC-transporter-permease
MHVWRRAGTIGIALYCLVPFYWMVVSSFRRTADIHDTTPLPSPWSLESYEAVFAADMGFGRSLLNSLVVAGVTTAVTLLVGTLAAYALARLSFRGKNVVLALVIAVSMFPGALLIVPLLKLFTAIGWINTYQAMIVPSMSFALPLTIWNLTTFFRQLPYELEQAAMIDGCTPFAAFRRVMLPLAAPGVFTTAILAFIATWNEFIIAVTMVNDQERQTATVRIAQFTGAAKFDTPFGTQMAAGVLVTLPLVLLVLFFQRRIVAGLTAGALK
>NZ_CP017717.1|WP_080047164.1|7797681_7798569_+|sugar-ABC-transporter-permease
MLSPTLLVLALVVFYPLVAAMRESFYESGQRLDADGFVVEGEWFAGLANYAGVAQQRFINAALNTTLFTVVTVSLEVVLGMAMALVMRRAFRGRAFLRASILVPWAVPTAVAGLMWKWIFQADGVANALLGTQILWTADGPWAKLAVIVADTWKTAPFVGLLVLAGLQIIPAEVYEAARVDGATPWQTFRRVTLPLVKPALLVAVLFRLMDALRIFDLPYVLVGPRKQSVETLSGLIWDEATRVHYGPASAYGTALFVYIAVIAFVFVKLLGADLLSDVRERRLSGRREGNARVA
>NZ_CP017717.1|WP_080042220.1|7796407_7797649_+|ABC-transporter-substrate-binding-protein
MKALHVTAAALALGAGLAACGSSPSPQAPTQERGPITFLGGKFEAESVQKIVDAWNAAHPQEKASVVLLPESADEQRRKLIQNAQTKSDAGDVMLIDAVWTSEFAANRWVEELKLDTTGFLPTTIETAKYRDKLYAMPVFTGTGLLYYRTDLVKQPPKTWAEMKKICDEVLPKQKGMSCYGGQFDKYEGLTVNFSEAVASAGGELLDASGQPQLTSEAAKQAARFLADAFKSGMIPKEAITYKEEEGRVAFQEGKLLFYRNWAYGYEAAQKTDGSSKVAGKFDVAPIPGLNGPGAGTLGGNNLAVSAFSKHKQTARDFVAFMTSAEQIKAFARTSSMPVPRAAIYDDPEMIKKYPYLPALKEGILAAKPRPKAVRYGDVTAAIQESAYAIITGAKPVDQGLSELQTALGPLLK
>NZ_CP017717.1|WP_080042219.1|7795178_7796411_+|Gfo/Idh/MocA-family-oxidoreductase
MVTLAVVGAGSRGTSYARHAIAAGGATVVAVADPLGSRRDRFPGAVPYADWRELAALPRQADAVVIATQDRDHVEPAVRFAELGYDILLEKPMAVSEDDCRAIVAAAERSGVVFAVCHVLRYTPYTRALKTLIDAGRIGEIVSVQHLEPVGWWHHAHSYVRGNWRRADESTFMLLAKSCHDLDWLVHLTGRQVARVSSFGGLHHFRPENRPAGAADRCLDCSVEPDCPYSARRIYLPLAGEHGWPLSVLTDDVSESGVLEALRTGPYGRCVYACDNDVVDHQVVNLEFEGGTTASFTMTGFTPAQHRQTRIFGTRGSIDGDGDRLTVHDFVTGRSSVVETRPGGDGTARGGHGGGDEALVEAFLTAVATRDRTPILSSPAESLHSHLIAWAAERSRLTGETVSLKEGTPR
>NZ_CP017717.1|WP_080042218.1|7793978_7795076_-|ROK-family-transcriptional-regulator
MTELRPGDASLLRKVNTKVTLSALRRAGVATLTQLGRVTGLSRQTVEAVLDELGERGYVREVPPDEGVMGRPARRFGFRADAGYVVGVEVGGDAIVAALADLNGEVIAWERAEISGDAAAHERLEAAERTALACVDGAGVAHRRVWTVAAGTSGIVDRTGRVSLSITLPGWTGVDLAGLAGRWFGCTALAANDANLAALAEHWRGSAQHAADVVYVLIGHRAGAGILIGGRLHPGRTGAAGEIGTLRQVGWEDAARELVKDASAAEVFEAALGGDRDAVRRVDRYAENLAIGASALVLAIDPDLLVLGGGYARAGAVLLEPLRRHLAELCVSAPEVVASTFGDEGVAIGAVRLALDHAEREILGL
>NZ_CP017717.1|WP_080042217.1|7793375_7793903_+|TetR/AcrR-family-transcriptional-regulator
MTTSSDDTRSRILAAARELFAERGYAATSLSDIAAAVGLTKTAVAYHFHPKDRLALELLSPVAGDMLALLDAPYASRAAFVEALVEFAVRYRSVIRLFMEDLAADDATTAPGSERDQIATFRDTIYAKLVGDDPGPEIRLKSWALLGALQWGAVKTADLPEEQVRDVLLEIAKAF
>NZ_CP017717.1|WP_080042216.1|7791050_7793276_-|MMPL-family-transporter
MTRLLGRLGGWCARHGWIVLITWVIAAGALMGSSLAFPSPTNSDASIPGTDAQRAHDLMKEGFGPGYAGGGTVQLLLYSADGPLIEDARKRAVERAMDELRTMPHVTKVETPFRAGGISSNLQIGLITIRLEGNDSDKIAQTTQELSKAADPAREAGLEVVPADSSTPADKEIKTGPSEIIGIVCALLVLVFAFGTLVAATVPIFAALVSVASGLGVIGLLGWVVDMPKQAGIMATMIGLGVGIDYALFLLSRHRRLLAEGVPVAESVRRTVASSGGAVVFAGGTVIIALSALLLAGFPLLATLGWVTGISVVAAVLTSVTLVPALLGLLGHRINSLKVPLLRGAGGSHAAGSGWAGLGAWVARRPWRTLIGSVVVLGALAAPALALQLGPLDEGYGTQGSESRRAYELMATGFGPGFNGPLIVVAELPAKVPDADAPIVDDLVREVKAVDGVKYVADPKLNTSGRSVLLQAIPEYAPSDQRSAQVVRDVRAISLPGVEVHVGGKVAGLTDAGDRMNERTPLVIGVVVLLSALLLLLAFRAPIVAIKAAVMNLVSLGAAFGALAMVFSIGLGSGLVGMDPPVNSSYVQTIFFSVPIESYVPLMLFAVLFGLSMDYEVFLLTAVRQSYLRHGDNARAVAEGLGSTGRVITSAALIMVAVFVAFIAYPDAMVKTFGVGLAVAIAVDATIIRGFLVPATMVLLGRLNWWCPRWLDRILPNLSVEGHEEDEPPAVRREEPVTAGV
>NZ_CP017717.1|WP_155129924.1|7803290_7804187_-|alpha/beta-hydrolase-fold-domain-containing-protein
MNPELEAFIPLFPAADLSDPAAARDGLAALASAVPAADSPDMVIEDRLIPGDPDVPVRVYRPLQAQGAIVWMHGGGWVMGSLDTEHPWASRAAELSGATVISVGYRLAPEHPFPAAFDDAYTVLTWVSEHAAELGIDPDRIAVGGHSAGANLAAAMTLRARDEQGPPICFQLLHQPGLDDRQQTWSARNFTDTPWMTRDKFATAWRHYMGSQPVTPYAAPARAEDLSGLPPAYIATAEFDPLRDEAIEYALRLLQAGVSVELHQWPGTFHGSQAIVSAEISQRQIAELATAIRHALAK
>NZ_CP017717.1|WP_080042225.1|7804283_7805354_+|PucR-family-transcriptional-regulator
MEALALRLSQLDQLAEGAIRVVMFYDTLMRRRVDLPGLARASAVLAECVAGVRLHGTGQVIRMAPGGTRALDPALPASTATAITLDDEEIGTAWLERPGPPGPLDELLLDRLAIAAAAVVERYGPARTTMADPALVELAISAEADEAARARALRLLGFAAGLPVRVVAVRSQPPLDQAGATRSRLPLDQVGALICPARPVKAAPLGDTGVILATTVDPAAFPAGVHAGIGPAGSPHLSWRQARTALRFTTPREPVVRYDDLGALALLAEIPQDVAQDNADVAAIARMAGSPEDLETLDVYCATGSLRRAADLLHLHHSSVARRLEQIGRTLGIELTEPTGLTRIRLALTAWRLLQA
>NZ_CP017717.1|WP_080042226.1|7805382_7806201_-|M55-family-metallopeptidase
MRVLVSVDMEGIAGVVHGDDVLPGHGEYERNRALLTAETNAAVRGVHAFEPRAQVLVTEAHAHFRNLLPERLDRRAELLRGTPKPYGMMAGLDGGVDAALFIGYHGKAGTARSVLAHTVSGGVVSDVRCNGRSLGELGLNAALAAHAGVPPVLVSGDDTVAAEAAEVVPGMHAVVVKRALGARAAAMLHPEEACDRIEQAVPAALAGRDAVRAPRFDGPVRLEVRVHRPRMTELVLLIPGMELADGCTLRYEAADFPTAYDVIELIATLGAL
>NZ_CP017717.1|WP_080042227.1|7806237_7807242_-|NAD(P)-dependent-alcohol-dehydrogenase
MRTYRVERPEIALQDEPVPEPGPGEILVRVHAAALNKRDLLILDGTYPLPARPGVIPLSDGAGEVVAAGPGVTRFGVGDRVMGSYWPRWHDGRLRPELIDQPGCTLDGMLTEYALLGEQAAVAVPEHLSWAEAATLPCAALTAWVSLTGGQKLLPGATVVTLGTGGVSLFAVQLARLLGCRVIVTTSRMDHADRLKALGADHVIDYPATPDWGRRVRELTGGQGADLVVDTAGPATIDQSVRAAALYGEVAVLITRDATSDRLEITNEAYASSLATLRRVFVGNRAELESLCAAVAAHELRPVIDRTFTDPHAAYRHYREGSPFGKVVIELAPA
>NZ_CP017717.1|WP_080042228.1|7807330_7808530_-|oxidoreductase
MQHRIVVLGAGYTGAFAAGRLARRLHPEDVAITLVNAEPDFVERVRMHQVAAGQDLKARPFSEMFAGTGVELKLGKVTGVDVERKTVTVTDPSRPGAPAAELAYDTLVYALGSAWNTQGVPGTAEHAYEIAGRPGALRLRERLAGLGAGQPVVVVGGGLTGVEAATEIAEARPDLDVALVARGDLGDWLAPKGRAHLRKVVRDLGITVHERTEVTAVEPDRITVAGGTAIPAAVTVWTTGFAVHPIAQATDLRLGATGQIVVDETMRSVSHPDVYAIGDAALAMGRGGKPLRMSCASGIPTAQRAADAIVARLTGGKLPHGAPGYFNQCISLGRKQGLIQYVTADDRAVPAALTGRLAAVYKELICKSAAWGVTNPTYGMPARRRRVTRRQAPAVKAVA
>NZ_CP017717.1|WP_080042229.1|7808634_7809579_-|RNA-polymerase-sigma-70-factor
MSLTVNDVDRFVAFKPRLEAIAYRLLGSASEAEDAVQETFLRWQAADLDRVEVPEAWLTKVLTNLCLNQLTSARARRETYVGRWLPEPLLEGDPMLGPADTAEQRESVSYAVLTLMERLSPNERAVYVLREAFDYPHREIAEILDITEAASQQLFHRAKKHVADGKARTEIDEATARRIVEEFLAAATSGRTEPLVRLLTADVISVGDGGGKIPARVKPFEGPLAVATFLRGLFKPAEAKRAMVGGRPEIYFTTANGEPAVVGVVDGRVVAIMCLEITADGIAAFRNQVNPDKLARATAQWAAGDHGGPLLTAL
>NZ_CP017717.1|WP_080042230.1|7809654_7809855_-|hypothetical-protein
MKKLFKLLLARRLAGTPLGLAALAAGWLLARRKRRRRAYEAERESAHVGHRSRTARGGGPRASARR
>NZ_CP017717.1|WP_080042231.1|7809884_7811954_-|PASTA-domain-containing-protein
MPTAQPLRTGDPQRLGEYVLTGRLGEGGQGAVFLGSRGGETYAVKLLHGPVGDERAAFLREVELAKHVARFCTAQVVDAGFDQGRPYIVSEYVDGPSLAREVALTGPRRDGALERLAVSTATALAAIHRAGIVHRDFKPQNVLLGSDGPRVIDFGLAKVLDAAATVSGRGVGTPAYMAPEQITASAVTGAADVFSWGATMCFAANATAPFGQDSVAPVLHRILTAPPELGRLDGRLRVLVASCLDKDARNRPSSRELLYELLGDSAEGVPPEVLRSPPPHVLRAVPPPLVPEQRSPETHRSSDEPPPTWPPMAEPETTGAPGDAYRLPPDATPPGDAYRPPPDTAAPATTGVPVPRQGGGPLRSGSGPAPPEGPVAADGAARGRGWPRAAIAVCAALLATAAVLLIVIIPTMSRRNTETAAPQAGDAPLTSQAPSTAPPTQKPSTGEPPAQQSRGPQEPALNNPPTVVRPATVAVPPLAGLDRQAAAKALKRAGLAVGAVTERDAPQKIGQVLTSRPAPGTVVSQGSKVTLQVSAGLPVPALTGLRRKAAAAALTGAGLKVGPITRSCSPEPDGQVLATRPKAGARVQGGTPVALTVARNGAPVPSVVGRSGEDARAELAAAGFSVQTRQQTVEDEARVGTVLAQSVQPGGCAGSGTQITLTVGVAAPPSPDPQDSPPVPTATESVPGD
>NZ_CP017717.1|WP_080042232.1|7812060_7813656_-|serine/threonine-protein-kinase
MSELRADDPRQLGAYRLTRRLGQGGQGVVYLGASPQGAPVAVKLLHASLSADQDARRRFLGEVEAVRKVAAFCTAQLLDADLEGDRPYLVSEYVDGPSLRELVVEEGPRRGGSLERLAIGTATALGAIHRAGVVHRDFKPGNVLLGIDGPRVIDFGVSRLMDAAVTTTHLPVGTPAYMAPERMKGESAGPAADMWAWGLTVAYTATGRHAYTAGTHQEVLARVLYGKPDLGALGGRLREIVEACLAAEPGERPDAEEVLRLLLGQEAAGVGDVLPTAAMLAVGGTGREPDAGDGREREAGDGPEREAGDGPEREVGDGRERDARSGRGREAGSGRERAGGTGRAGSARLSAVVGLGAAEAAPGVITDPDPTTSFPAITAPLIAARAKAKARDRPAPGRRRIRPWQAAVVALGVAAAAGGLLLWTRGAAEGLAGTWTGSAEHFSAGRVFPVELRLTGDDGGAMRWGADLHCSGRLARTGSGPVFLLDQVRGEECYPGTLRMSPTSDANQMAIKVTRDGKDEVTYSGKVARTS
>NZ_CP017717.1|WP_080042233.1|7813704_7815105_-|serine/threonine-protein-kinase
MPHADDPSRLGNYRVLRRLGQGGQGVVYLGESPQGSLVAIKLMHARLSGDPDVRRRFLGEMDAVRRVAAFCTAQLLDADLDGDRPYLVSEYVEGPSLAQHVTEKGPRSGGSLHRLAIGTATALGAIHRAGVVHRDFKPPNVLLGIDGPRVIDFGVSRLMDAAASTTGVSLGTPAYLAPERVQGETAGPAADLWAWGLTVAYTATGRHAYRADTYQEVLARILYGKPDLGTLGGPLREVVEACLRHDPRERPDAEEVLRWLLGHEPGADDVLTTGALAAVGPAPVGPEDDTGPSPDAEARTETPARRRWWRGRQVVVAAAVGVAVAVAGGVLWWAASREPVAAGPPQVAPPSRTPSASVTRDAAPSLDGTWTGSAEHPTAGRVFPVELRLRAGGRSSMRWGADLHCSGRLKPGGNPLVFTLDQVKGEACYPGTLRFVPSADPDRAAVSVTRKGQDEVTYAGKVSRGS

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Crispr_ID: NZ_CP017717_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_19

7937161-7937252

Orphan

Consensus_repeat	Method
CGACGTGCTGGCCGAGACGCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_19

>merge|NZ_CP017717|19|7937161-7937252|CRISPRCasFinder
CGACGTGCTGGCCGAGACGCTGCGCCGGGCGTGCGAGGAGGAGAAGGTGGAGCTGCGCGCCGACGACGCCGCCGTGCTGGCCGAGACGCTGC

>NZ_CP017717|19|17|7937161-7937252|CRISPRCasFinder
CGACGTGCTGGCCGAGACGCTGC	GCCGGGCGTGCGAGGAGGAGAAGGTGGAGCTGCGCGCCGACGACGC
CGCCGTGCTGGCCGAGACGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080042312.1\|7928663_7929614_+\|5-dehydro-2-deoxygluconokinase	unknown	unknown	gnl\|CDD\|275175
NZ_CP017717.1\|WP_080042324.1\|7944502_7945336_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NZ_CP017717.1\|WP_080042317.1\|7937707_7938238_-\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|188337
NZ_CP017717.1\|WP_080042322.1\|7942098_7942950_-\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|366491
NZ_CP017717.1\|WP_080047177.1\|7936494_7937052_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP017717.1\|WP_080042314.1\|7931327_7933223_+\|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)	unknown	unknown	gnl\|CDD\|275170
NZ_CP017717.1\|WP_080042325.1\|7946328_7947258_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NZ_CP017717.1\|WP_080042320.1\|7939853_7940954_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|184689
NZ_CP017717.1\|WP_080047174.1\|7927196_7928378_-\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|213993
NZ_CP017717.1\|WP_080042321.1\|7941078_7942095_+\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP017717.1\|WP_080042316.1\|7934976_7936506_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|235704
NZ_CP017717.1\|WP_080042315.1\|7934318_7934912_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP017717.1\|WP_080042311.1\|7926312_7927206_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|275172
NZ_CP017717.1\|WP_080042313.1\|7930536_7931379_+\|5-deoxy-glucuronate-isomerase	unknown	unknown	gnl\|CDD\|275171
NZ_CP017717.1\|WP_080042318.1\|7938348_7939173_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP017717.1\|WP_080042319.1\|7939169_7939838_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047175.1\|7929625_7930540_+\|deoxyribose-phosphate-aldolase	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047176.1\|7933299_7934268_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP017717.1\|WP_080042323.1\|7943041_7943599_-\|ribosome-recycling-factor	unknown	unknown	gnl\|CDD\|178850
NZ_CP017717.1\|WP_080047179.1\|7943642_7944449_-\|UMP-kinase	unknown	unknown	gnl\|CDD\|234735

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080042312.1\|7928663_7929614_+\|5-dehydro-2-deoxygluconokinase	gnl\|CDD\|275175	TIGR04382, myo-inositol_catabolism_protein, 5-dehydro-2-deoxygluconokinase. All members of the seed alignment for this model are translated from the iolC gene of known or putative inositol catabolism operons. Members with characterized function are 5-dehydro-2-deoxygluconokinase, the enzyme catalyzing the fifth step in degradation from myo-inositol or closely related compounds. Note that many members of this family are fusion proteins with an additional C-terminal domain, of unknown function, described by pfam09863. [Energy metabolism, Sugars].	4.89639e-138
NZ_CP017717.1\|WP_080042317.1\|7937707_7938238_-\|DivIVA-domain-containing-protein	gnl\|CDD\|188337	TIGR03543, divI1A_rptt_fam, DivIVA domain repeat protein. Members of this protein family contain two full and two partial repeats of a domain found at the N-terminus of Bacillus subtilis cell-division initiation protein DivIVA. The portion repeated four times in these proteins includes the motif GYxxxxVD.	4.88594e-14
NZ_CP017717.1\|WP_080042322.1\|7942098_7942950_-\|phosphatidate-cytidylyltransferase	gnl\|CDD\|366491	pfam01148, CTP_transf_1, Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.	5.20152e-52
NZ_CP017717.1\|WP_080047177.1\|7936494_7937052_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.40484e-16
NZ_CP017717.1\|WP_080042314.1\|7931327_7933223_+\|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)	gnl\|CDD\|275170	TIGR04377, 3D-35/4-trihydroxycyclohexane-12-dione_hydrolase, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase. Members of this protein family, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (iolD), represent one of eight enzymes in a pathway converting myo-inositol to acetyl-CoA. IolD hydrolyzes the cyclic molecule 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione to yield 5-deoxy-D-glucuronic acid. TPP is a cofactor. [Energy metabolism, Sugars].	0
NZ_CP017717.1\|WP_080042325.1\|7946328_7947258_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.27487e-167
NZ_CP017717.1\|WP_080042320.1\|7939853_7940954_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|184689	PRK14459, PRK14459, ribosomal RNA large subunit methyltransferase N; Provisional.	0
NZ_CP017717.1\|WP_080047174.1\|7927196_7928378_-\|PHP-domain-containing-protein	gnl\|CDD\|213993	cd07438, PHP_HisPPase_AMP, Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound. The PHP domain of this HisPPase family has an unknown function. It has a second domain inserted in the middle that binds adenosine 5-monophosphate (AMP). The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to give histidinol. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to the other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.	5.47658e-17
NZ_CP017717.1\|WP_080042321.1\|7941078_7942095_+\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	2.31924e-14
NZ_CP017717.1\|WP_080042316.1\|7934976_7936506_+\|NAD(P)-binding-protein	gnl\|CDD\|235704	PRK06126, PRK06126, hypothetical protein; Provisional.	4.27559e-94
NZ_CP017717.1\|WP_080042315.1\|7934318_7934912_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.96059e-09
NZ_CP017717.1\|WP_080042311.1\|7926312_7927206_-\|TIM-barrel-protein	gnl\|CDD\|275172	TIGR04379, myo-inositol_catabolism_protein, myo-inosose-2 dehydratase. Members of this family include the enzyme myo-inosose-2 dehydratase, product of the gene iolE, as found in inositol utilization cassettes in many species. [Energy metabolism, Sugars].	3.62563e-46
NZ_CP017717.1\|WP_080042313.1\|7930536_7931379_+\|5-deoxy-glucuronate-isomerase	gnl\|CDD\|275171	TIGR04378, Myo-inositol_catabolism_IolB_domain_protein, 5-deoxy-glucuronate isomerase. Members of this protein family, 5-deoxy-glucuronate isomerase (iolB), represent one of eight enzymes in a pathway converting myo-inositol to acetyl-CoA. [Energy metabolism, Sugars].	3.58748e-105
NZ_CP017717.1\|WP_080042318.1\|7938348_7939173_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.28826e-34
NZ_CP017717.1\|WP_080042324.1\|7944502_7945336_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	3.84949e-126
NZ_CP017717.1\|WP_080047176.1\|7933299_7934268_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.59218e-42
NZ_CP017717.1\|WP_080042323.1\|7943041_7943599_-\|ribosome-recycling-factor	gnl\|CDD\|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	6.80353e-102
NZ_CP017717.1\|WP_080047179.1\|7943642_7944449_-\|UMP-kinase	gnl\|CDD\|234735	PRK00358, pyrH, uridylate kinase; Provisional.	2.69427e-147

>NZ_CP017717.1|WP_080047177.1|7936494_7937052_-|GNAT-family-N-acetyltransferase
MPCRQSIRVPKQSNVTHRIALIMAVMSISVREIRPGDLPAVTRVLTESWGGTTLMVLGSGRQVDAAKLPGFVAEVEGELAGLVTYLEDGGAVEIASLDAVLPGKGVGRALLDAVRAVAAERGARRLWLITTNDNTHALRFYQRYGFDLVALHRNAMDRVRAIKPGIPAESDGIPIRHELELELLL
>NZ_CP017717.1|WP_080042316.1|7934976_7936506_+|NAD(P)-binding-protein
MTTTTQTPVLIVGGGYAGLASALFLAHQGVRCVLVDRHPGGSILGRARGINPRTMEIYRPLGLEAAIKEAGRPFDGESGVARCTTLLDEWHWIFDADAPRALPHLTAGEFGLADQSTMEPILARAARERGAELRFDTQCESVDDGPDGVTVVTRDRTTGERRTYLAQYVIAADGYRGTIRQRYGIGRTGPGVQRSYVSCVFKADLSDIITRRAMFWILGDPVTGALVSHALPHHWGLGLSYDPATESPDDFTDERCAETARRLIGRDVPIDIVGRAAWEEAAYVADRFRAGRVFLVGDAAHVWPPAGGLGANSAVQDAHNLAWKLAAVLAGRASDALLDTYEAERRPVALELADLTVRSQAARFGPNPGEDPLDAVLCVLGQRYTSAAMIGPGPGAVFGDGVEQHARPGTRAPHLWLDHDGRRIGVHDLFHDSFVLLTDSEPWAKAAADVEGVRAYRIGADVIDVEHAWRSRYDGAAAVLVRPDGYVAWRGEGDPAALAGVLGRVLLKQ
>NZ_CP017717.1|WP_080042315.1|7934318_7934912_-|PadR-family-transcriptional-regulator
MPLDRGSPLALTVLALLRYRPLHPYGIQRLLKQWGKDQVVNVGQRTGLYRTIDRLGEAGLIRVRETGRDQQYPERTVYEITDDGQVTLRRWLDEMLSVPRQEFPQFPAALSNALMLAPDELAQALERREQVVAGTLAALEEQLADTGVPRVAMLEVEYLRAVTEAEARWLRGVVEDLRGGRLTWSRESLEEAAAALE
>NZ_CP017717.1|WP_080047176.1|7933299_7934268_+|AI-2E-family-transporter
MLGWFAVIAVAFFCLYHVRTVALSIVIGVFLTALLLPPARWVRSRGVGRAAATAIVFAGALLVAGAVIALVVPPTVASVSELRASVGKVLDDLHHLAARLGLDDRQMLAQARDYLSGQSRQITTGALAGVKTVGEIVVGAVLAIILSVYFVHGGDRLFRWLVELMPASSRARVTETGELIFSVVGRYIHGVAIVGLVDAFFIGISLWILGVPVALPLAVLTFVGAFLPVVGAFFAGLLAAVVALVAKGWLVALIVVAVTVAVQQIEGHVLAPQIYGKALDLPGAVILVAITVGSVIAGIAGAFLAAPVTSVVVALLRHPRST
>NZ_CP017717.1|WP_080042314.1|7931327_7933223_+|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)
MGHPAPRPQTAVREDFVIRLTVAQAVVRFLARQWSERDGVERRFFGGCVGIFGHGNVAGLGQALATSTEDLPYRLSRNEQAMVHTTAAYARAANRLATLACTTSIGPGATNMITGAAGATINRLPVLLLPGDIFSTRAASPVLQELEDQRSYDISVNDCFKPVSRYWDRINRPEQLPSALLAAMRVLTDPAETGAVTLALPQDVQAEAFDWPDELFARRVWHIPRPRPERAALARAAELIRSAARPIIVAGGGAIYSEATDTLRAFAEACGIPVAETQAGKGALPYGHPLALGAIGATGTTAANALAREADLVIGVGTRYSDFTTASRTIFAPDAAFLNLNVTGFDAAKLSGLQLVADAREGLSDLLEACAGHRTPDAYRQRAAELTREWDAAVDAAYALEGSPLPQSAVIGAVNAAAGDDGVVVCAAGSMPGDLHKLWRPSGPGSYHVEYGYSCMGYEIAGGLGVKLAAPEREVFVLVGDGSYLMMAQELVTAVADGVKLVVVLVDNSGFASIGRLSESVGAERLGTAYQRRDGGPLPVDLAANAASLGATVLRPESVADLRKALDTARSADATTVIYVRTDRLADDAPSSEAWWDVPVAQVATTSATYAARETYEANKRSQRPHLTPPG
>NZ_CP017717.1|WP_080042313.1|7930536_7931379_+|5-deoxy-glucuronate-isomerase
MTHLPYGKTASGPWSVEITPSLAGWTYSGLRVADLTDAPISFDTGEEEMIVLPLAGSCTVTLPDDTFVLTGRASVFDSPSDFAYVPTSTQVTVEGAGRIAFPSARATRAHPARYVAAAEVAVEIRGAGQASRQVNNFCSPDAYQGCDKLMAVEVLTPSGNWSSYPPHKHDTPHEGEAVLEEIYYFEVADQGIGYQRVYSSERGHIDTLAEVSSGDVVLVPYGYHGPSMAAPGYDLYYLNVLAGPAEQRSMAFCDDPRHAWIRSSWDTQHLDPRLPFGRTS
>NZ_CP017717.1|WP_080047175.1|7929625_7930540_+|deoxyribose-phosphate-aldolase
MTTPAAPSAGPPGDYGRLTRIRATQPEEIAAAAARRERRGLPGEGERLLIIAADHPARGALGVRDRPLAMGSRYDLLDRLRLALSRPGVDGILASPDVLEDLLLLGDLEGKLAFGSMNRGGLQGSVFEADDRFTGFDAAAIDAMRLDGGKMLCRIDPSDHATVTTLESCARAVSELARRRLVAMVEPFWSLRTESGALRNDLSPDAVIRSISVAQALGVTSAYTWLKIPAVAEMERVMAATTLPALLLGGDPPDIDAAYADWHRALSLPGVRGLVVGRALLYPPDDDVAAAVDGAAALVREARA
>NZ_CP017717.1|WP_080042312.1|7928663_7929614_+|5-dehydro-2-deoxygluconokinase
MYDLITIGRSGVDVYPLQTGVGLADVETFGKFLGGSPTNVAVAAARHGLRSAVITGVGADPFGQYVRRAIRGFGVDDAFVHTIEGRPTPVTFCEIFPPDHFPIYFYRGEHPPDLQLTPSMLDLDAIAGAGLFWFSLTGLSQEPSAAAHAAALSARTSALNPGLTVFDLDYRAVLWESREAAHEAAQRMLPRANVAVGNLEEVETAVGVRDPEAAAQALLDAGVRLAIVKMGPEGVFARTSEESALVEPMEVKVVNGIGAGDAFGGALCLGLLRGWPLERTLRFANAAGAFVAARLACADAMPSTSEVDDLLNGASC
>NZ_CP017717.1|WP_080047174.1|7927196_7928378_-|PHP-domain-containing-protein
MNGHWSLDDRLARSLREVPFEVPAGAAAVTVRLSYDRSQGVIDLGCAGPGGFRGWSGGARDTYTIGPAWATPGYLPGEPEPGTWHVWLRLHRIPPQGLDYTLDVSVHRTPPPEPVEAAEPPRGERPPRRAIPDLEGLRWYAGDFHAHTVHSDGSLTVAELAELARGRGLDFLAVTDHNTISHHPWLAGAGRDITLIPGQEVTTDRGHANVFGEVGWVDFREPADSWVEHAERAGGLISVNHPLGADCAWLLPITRRPRVAEVWSSGWWDRRWGAPLAWADAWRDDVIAIGGSDFHQHGSDGLPGTPTTWVLAEDPAAVLDGVRAGRTAVSTGPDGPLLLRLGDELIALDADGLVLVRPDGTRQVVRGERALLPAIDGPHRLETYENEVIALCA
>NZ_CP017717.1|WP_080042311.1|7926312_7927206_-|TIM-barrel-protein
MRVRKVANAPVSFGVFELSDGPPPLTPDEMVRALAEAGYEGIDSGPIGYLGTGSELRERLSGAGLLLCGGWVDLPFHDADAYEKALPTLTAALDVFAAAPAGDLPPRPTIACPGTPERFARPGGTAPGLPAAEWPAFAARIQDATERCRARGFEPAFHHHLGTHVETPDDVERLLELTDVQLCLDTGHLLLAGGDPVAALRAWSERVGHVHIKDGDTAVLARALDDGVDLRELMGRGGFAPLGEGELDLPAVVRTLDEIGYAGWIVIEQDTLPGRRTVAQNIADQAANRRKLKDLGL
>NZ_CP017717.1|WP_080042317.1|7937707_7938238_-|DivIVA-domain-containing-protein
MGMRSGYDPVEVDALIGRIESTLGRGPHLLEPVTADEVRTATFRAKRGGYQETAVDFALEAFVVALEAQAKRPIRLAMAEPTGEMLREQWFEQQAARVERVAFRPGRMGTGYNEDEIDAFLDRIVATLRGTTDYPVTAKEVREAKFSTVMFKAGYLIADVDSFLAGIADVLEQRAL
>NZ_CP017717.1|WP_080042318.1|7938348_7939173_+|ATP-binding-cassette-domain-containing-protein
MRLTNVSFRYRRRDPLVIEDADAHLAPGDVIELTGVNGAGKSTLLRLLAGLARPTTGTISERPPVVGFAPDRFPASQPFTVAAYLRHMSRVRGGARWEPWAERLNMRHLLATPLGDLSKGSAHKVGLAQALMAEPGLLILDEPFAGLDADTRQALPSIAAEVAGRGGIVIASDHQGGLRGLPGLRHWSMVDGRLKEGTAAPAAPPPSQATVAVTLPAEELPRFLARMREEGFQARELDTAEEARELPPAAQGRETLAPARPRDTSATREAEESA
>NZ_CP017717.1|WP_080042319.1|7939169_7939838_+|hypothetical-protein
MIALAAFRLAAYVRSHRVFQALLLTLALLAIVHGSRAPRGAEATVLVDGAVLLVPVLAWAARSLLDTEPDRQREMSAVQVGGRGKEVVAGLLAAFAACAVFAALGLVWALLLGISGSPPPGLLLAGLILYAISALTGTALGALTSRAVLPSPAVSIMALLLGFLAMLLLSATSLYWLTVPLIPWMKAANSGELLGAFSTLAWISLAWCLIGLTAYGWLRRRS
>NZ_CP017717.1|WP_080042320.1|7939853_7940954_-|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MSQPPGQLTFVAPRRAKPARHLADLSMAERRAAVTELGEKAFRADQLSRHYFERLTTDVQAMTDLPAASREKLAALLPPLLTSVRELATDRGTTRKTLWRLFDGALVESVLMRYPDRVTMCVSSQAGCGMNCPFCATGQAGLTRNMSTAEIVEQVVAGARALAAGEVPGGPARVSNVVFMGMGEPLANYKQVIGAVRRLVEPAPHGLGISARGVTVSTVGLVPAIGKLADEGLPVTLALSLHAPDDELRDTLVPINTRWKVSEVLDAAWAYAAKTKRRVSIEYALIKDINDQEWRADLLGKLVKNKLVHVNLIPLNPTPGSKWTASRPEDERAFVRRLEFHGVPVTVRDTRGREIDGACGQLAAAE
>NZ_CP017717.1|WP_080042321.1|7941078_7942095_+|suppressor-of-fused-domain-protein
MAIFRSASGEGGTEVVLAAGNPYGSRTLVVERDEDSSVAYLCSPDGTVHGAVWLANHRPAPAVVDLARINAGLPPLMPRPNTLHPEGRRPLGQLSPLWFEEGDGVALYEDDELLAVIPGWADMSRGMPGYARDAVGESPFAWALSEALEGLRPRISNARSYWRWRHSEGSWPSFQQFVMGHLDNVLGPAGRYWDASGERLPTVGITERPPHGERGFTVLSTVGMSCQRMPTVEQWIDKPGAYARIELAVATRDDPKDAALLLVWLAQYPWHSVTWLGHGHTAKWYHEPSTFPLGPQYSGVLMQANPAHMPDMSGFAFGGEIVRWLWLSPVTTQALQAH
>NZ_CP017717.1|WP_080042322.1|7942098_7942950_-|phosphatidate-cytidylyltransferase
MEKSVEERTAGTSSSGGSRTGRNLPAAIAVGVVLGALVLGTVYTIKELFLIVVVGAVGVGVLELVKAFATRDIRVPAVPVLVGLVAMQAGAYWGGPEWLLASFAVFAFVLLIWRMFSDGTDGYVRDASASVFTLFYPAMLSAIVALMLHPGDGNHRVLIFIAVTVASDIGGYIAGVLFGRHQLTVISPKKTWEGLAGSVVACTAVGAWLVSWLLHGQIWQGALIGALAALLATVGDLVESMIKRDLGIKDMGTILPGHGGLMDRLDSLVTTLVPVWLLMTLFF
>NZ_CP017717.1|WP_080042323.1|7943041_7943599_-|ribosome-recycling-factor
MIDETLLEAEEKMDKAVSVAKEDFATIRTGRVTPSMFNKINAEYYGTPTPIQQLASFHVPEARMVTIQPYDKGSTNAIIKAIRDSDLGVNPTDDGQVIRVTFPELSEERRKEYIKVARNKGEHAKVSVRNIRRSAKETLDKMIKDGEAGEDEVRRAEKELDDLTQKHVAKIDELLKHKEAELLEV
>NZ_CP017717.1|WP_080047179.1|7943642_7944449_-|UMP-kinase
MQDHRESAHESTRTAASSSQDPPAQSPQSPLRWKRVMLKLSGEAFAGSEPLGIDPTIVDHLADSIAEAVKEGVQVAVVVGGGNMFRGATLSQGGIDRARADYMGMLGTVINCLALQDFLERRGVETRVQTAITMQQVAEPFLPRRAIRHLEKGRVVIFGAGLGSPFFSTDTAASQRALEIGAEALLKGTQVDGIYDSDPRKNPDAVRFDHLDYGEVLLRDLAVMDATAISLCKDNDLPIVVFDLMGEGNILRAVRGEKIGTLVSPAGK
>NZ_CP017717.1|WP_080042324.1|7944502_7945336_-|elongation-factor-Ts
MASVNMADVKRLREITAAGMMDCKKALEESEGDFDRAVELLRLKGAKDVGKRESRTASNGLVALKQDGDSSAALVEINCETDFVAKGERFQELAEQVVTHVLATKPADVAALLESSFDGKTVKEHLDTANAALGEKIEIRRFAVLEGGYIGAYMHKTDPALPPAVGVLVQLDKPNAEVAKDIAQHAAAMAPQYLKAESVPAEVVEKERKLFEEMTREEGKPEAAIGKIVEGRVNGWYKDFTLLQQAFVKDNKKSVGKYAEENGVEVLAFVRFKVGQA
>NZ_CP017717.1|WP_080042325.1|7946328_7947258_-|30S-ribosomal-protein-S2
MAPVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLQKSLSYIDRAYDFVKETVAHGGTILFIGTKKQAQEAISEQAARVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEELDFDNVAGSGLTKKELLMRRREKDKLERTLGGIRDMGRVPSAVWVVDTKKEHIAISEAKKLGIPVVAILDTNCDPDEVDYPIPGNDDAIRAVGLLTRVVADGVAAGLMARSGAARGDEKPAAAEPLAEWERELIEQGTGEAPAAAEAAPEAAPEAAAEEAPAAEEAAPAEAAADEAPAAAAEGETEQQA

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Crispr_ID: NZ_CP017717_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_20

7957945-7958094

Orphan

Consensus_repeat	Method
GGGCGAGCTCGTGCCCGGAGCGGG	CRISPRCasFinder

3 spacers

csa3

The CRISPR arrays of NZ_CP017717_20

>merge|NZ_CP017717|20|7957945-7958094|CRISPRCasFinder
GGGCGGGCTGGTTACCGGATGGGGACGGCTGGTCGCTGGAGCGGGCGAGCTCGTGCCCGGAGCGGGCGGACGGGTTTCTGGACCGGGCGGGTTAGTGCCCGGAGCGGGCTGATGGGTCCCAGGACGGGGCGAGCTCGTGCCTGGAGCGGG

>NZ_CP017717|20|18|7957945-7958094|CRISPRCasFinder
GGGCGGGCTGGTTACCGGATGGGG	ACGGCTGGTCGCTGGAGC
GGGCGAGCTCGTGCCCGGAGCGGG	CGGACGGGTTTCTGGACC
GGGCGGGTTAGTGCCCGGAGCGGG	CTGATGGGTCCCAGGACG
GGGCGAGCTCGTGCCTGGAGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080042337.1\|7963157_7964018_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP017717.1\|WP_080042327.1\|7948305_7950051_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP017717.1\|WP_080047179.1\|7943642_7944449_-\|UMP-kinase	unknown	unknown	gnl\|CDD\|234735
NZ_CP017717.1\|WP_080042326.1\|7947631_7948258_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP017717.1\|WP_080042333.1\|7958470_7960003_-\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679
NZ_CP017717.1\|WP_080042338.1\|7964160_7964523_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NZ_CP017717.1\|WP_080042325.1\|7946328_7947258_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NZ_CP017717.1\|WP_080042335.1\|7961843_7962512_-\|ribonuclease-HII	unknown	unknown	gnl\|CDD\|234574
NZ_CP017717.1\|WP_080042328.1\|7950106_7951048_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080042336.1\|7962564_7963158_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP017717.1\|WP_080042340.1\|7965521_7966022_-\|ribosome-maturation-factor-RimM	unknown	unknown	gnl\|CDD\|234650
NZ_CP017717.1\|WP_043634919.1\|7966091_7966337_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|179479
NZ_CP017717.1\|WP_155129939.1\|7956585_7957797_-\|DNA-protecting-protein-DprA	unknown	unknown	gnl\|CDD\|376794
NZ_CP017717.1\|WP_080042334.1\|7960003_7960363_-\|YraN-family-protein	unknown	unknown	gnl\|CDD\|237119
NZ_CP017717.1\|WP_080042324.1\|7944502_7945336_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NZ_CP017717.1\|WP_080042341.1\|7966338_7966779_-\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|184724
NZ_CP017717.1\|WP_080042331.1\|7954320_7955250_-\|tyrosine-recombinase-XerC	unknown	unknown	gnl\|CDD\|234698
NZ_CP017717.1\|WP_155128440.1\|7951573_7951915_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080042323.1\|7943041_7943599_-\|ribosome-recycling-factor	unknown	unknown	gnl\|CDD\|178850
NZ_CP017717.1\|WP_026215037.1\|7961480_7961804_-\|DUF2469-domain-containing-protein	unknown	unknown	gnl\|CDD\|313765

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080042337.1\|7963157_7964018_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.23794e-39
NZ_CP017717.1\|WP_080042327.1\|7948305_7950051_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.39775e-65
NZ_CP017717.1\|WP_080047179.1\|7943642_7944449_-\|UMP-kinase	gnl\|CDD\|234735	PRK00358, pyrH, uridylate kinase; Provisional.	2.69427e-147
NZ_CP017717.1\|WP_080042334.1\|7960003_7960363_-\|YraN-family-protein	gnl\|CDD\|237119	PRK12497, PRK12497, YraN family protein.	8.07211e-43
NZ_CP017717.1\|WP_080042333.1\|7958470_7960003_-\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP017717.1\|WP_080042338.1\|7964160_7964523_-\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	3.46073e-64
NZ_CP017717.1\|WP_080042325.1\|7946328_7947258_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.27487e-167
NZ_CP017717.1\|WP_080042335.1\|7961843_7962512_-\|ribonuclease-HII	gnl\|CDD\|234574	PRK00015, rnhB, ribonuclease HII; Validated.	2.27546e-92
NZ_CP017717.1\|WP_080042336.1\|7962564_7963158_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.9469e-39
NZ_CP017717.1\|WP_080042326.1\|7947631_7948258_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.85545e-11
NZ_CP017717.1\|WP_080042340.1\|7965521_7966022_-\|ribosome-maturation-factor-RimM	gnl\|CDD\|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	2.2339e-64
NZ_CP017717.1\|WP_043634919.1\|7966091_7966337_-\|RNA-binding-protein	gnl\|CDD\|179479	PRK02821, PRK02821, RNA-binding protein.	1.06166e-33
NZ_CP017717.1\|WP_155129939.1\|7956585_7957797_-\|DNA-protecting-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	1.38477e-81
NZ_CP017717.1\|WP_080042324.1\|7944502_7945336_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	3.84949e-126
NZ_CP017717.1\|WP_080042341.1\|7966338_7966779_-\|30S-ribosomal-protein-S16	gnl\|CDD\|184724	PRK14520, rpsP, 30S ribosomal protein S16; Provisional.	4.75907e-68
NZ_CP017717.1\|WP_080042331.1\|7954320_7955250_-\|tyrosine-recombinase-XerC	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	5.59176e-125
NZ_CP017717.1\|WP_080042323.1\|7943041_7943599_-\|ribosome-recycling-factor	gnl\|CDD\|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	6.80353e-102
NZ_CP017717.1\|WP_026215037.1\|7961480_7961804_-\|DUF2469-domain-containing-protein	gnl\|CDD\|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	1.0485e-59

>NZ_CP017717.1|WP_155129939.1|7956585_7957797_-|DNA-protecting-protein-DprA
MGSLVAQYGAPHAVECIRARTLPPEFVARQAQQERPPNLTSALNAWYTRLAAANPAADIEAGQRSGARLIIPGSPEWPTQLDQLGRSRPLGLWVHGNADLRFSCLKSVAVVGARAATSYGSHIAAEFGVGLSESGWIVVSGGAFGVDGAAHKGALAADAPTVVVLACGVDVSYPSAHESLFAEIREKGVLISECPPGVHPTRARFLIRNRLIAALSRGTVVVEAAIRSGALNTATHALSLNRHLGAVPGPVTSAMSAGCHRLLRERKAVCITSPEDMIDLVGALGDDLAPQLRAPAVPRDRLNEPTRRVLDAVPTRGGAGPASIAVAAGLGLDTTLSALGGLAAAGYIERTSKGWRLRKQTTTYRKASDSTALEPPPTPEPDPTDLPPPPDEYDDPPKAAAYK
>NZ_CP017717.1|WP_080042331.1|7954320_7955250_-|tyrosine-recombinase-XerC
MLLGRGCGAEAGREIGVDREEVVREFERYLRLERDLSPHTVRAYLTDVNSLLDHTGGDVEGLDIGVLREWLAGQHAAGKARATLARRTACARTFTAYCHRRGWLQTDSGLLLGSAKSPRTLPSVLDQRQAEAVLEAPATGDPKELRDQALLELLYATGVRVSELCALDVDDVDRERNIIRVLGKGRKERSVPFGVPALRALDRWCIHGRPLWMRAGSGPALFLGVRGGRIDAGTVRRVVHARLAQVEGAPDMGPHGLRHSAATHLLEGGADLRSVQELLGHASLNTTQIYTRVSIERLRAAYRQAHPRA
>NZ_CP017717.1|WP_155128440.1|7951573_7951915_-|hypothetical-protein
MGLALGGLSPVMMAGLSPGGLSLVMVAGSSLGGLSPGMVAGFSLGELSPVMAARLWASGLAPMVVAGLSVGGLSWVARFSGGWLLPAAVPGLLGEACGMEVLVGVLGERWRAA
>NZ_CP017717.1|WP_080042328.1|7950106_7951048_-|hypothetical-protein
MLLLHFDGRRWRERPAPPMTWDSKDDERFPVLVATGSRDAWVFAATAALSAHHWDGERWSPVGLPDMDYDAGERAGAAALAADDVWLVVGDRAAHWDGRGWTVMRLPAWAEAVSAVAPDQVWAVGGTGRPLARGHSASQAAAMLWDGRSWRLVPVPEDRTPSKEINSQGRPDGSIPSIRLTQVVAHTPGNVWAIGTRRVFDYEDGSRSSTVTLHWDGTAWARVVGSAYVGAAGSDGVDGIVLVDGDVGAEGGLSGAVRVAPDGSRTELPPMAGVDRRREVDVSAASAVPGTGRVYAVGLVYGKGYGPMIARYR
>NZ_CP017717.1|WP_080042327.1|7948305_7950051_+|MFS-transporter
MKDYLHSYEAFPSQLPRALTCHDHASARLHLHCGTDHLHLRLCTHPHLHLRLCTHPTSTSASTFASASTPTSPSTPTSPSTPASPSTPTSGNTPPPTPAQAVRPSDTSTPNQPPPSSDTSAPNQPPPSSDTSAPNEPPPPPLRKQRDYRLLWTARTISVTGSEVSKLAIPLTAVTLLAASPAQMGILTAAASVPVLLFGLQSGAIADRLTRHRPLMIACELVSCAAAATIPIAWLLGVLNVVWLIAVALVIGTAGVLFKAANFPHLAAVVDPSHRTEAMAGFHASYSVASVSGPGLAGLLVQLLTAPLAVLAEAFAFLTSALLLRSIRTPEHNTPSASQSMWRDVVEGLRTSVTHPVLRALLGAGVTINFFAMAYTAVYMLYMVNTLAIPKALIGVLIALSGAGGLLGAWLTARLSKRYGENRVLLISVIFFPIEILAVGLLTGPLWWKLALLALTSTITGGIVVAFATCMGAITLRETAPELRGRVNATTTFAVQGVLALGGLAGGFLAEWLGLRPVILICAAGIALSTIWIWTSPLRPNRLPHAPNTRDTRDTSDASAPTPSFAQSTSHLINSKRHSQP
>NZ_CP017717.1|WP_080042326.1|7947631_7948258_-|winged-helix-turn-helix-transcriptional-regulator
MTQDREGLSDPKAMRALAHPARLMILNRLRVEGSATATEVAEIAGITPSAASYHLRMLAKYGFVEDAPPRGDGRERLWRGVDKPLSVGVRPDDQPDVRAAKVLLIAALRKGANEEADRALAQSDLEPEEWREVTLFSQHRLRVTAEELGRLTREIEGLLEPYVARNRSERDAPEGARLVEAQVNLFPVAARVVPGLPTEDHGARPVPD
>NZ_CP017717.1|WP_080042325.1|7946328_7947258_-|30S-ribosomal-protein-S2
MAPVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLQKSLSYIDRAYDFVKETVAHGGTILFIGTKKQAQEAISEQAARVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEELDFDNVAGSGLTKKELLMRRREKDKLERTLGGIRDMGRVPSAVWVVDTKKEHIAISEAKKLGIPVVAILDTNCDPDEVDYPIPGNDDAIRAVGLLTRVVADGVAAGLMARSGAARGDEKPAAAEPLAEWERELIEQGTGEAPAAAEAAPEAAPEAAAEEAPAAEEAAPAEAAADEAPAAAAEGETEQQA
>NZ_CP017717.1|WP_080042324.1|7944502_7945336_-|elongation-factor-Ts
MASVNMADVKRLREITAAGMMDCKKALEESEGDFDRAVELLRLKGAKDVGKRESRTASNGLVALKQDGDSSAALVEINCETDFVAKGERFQELAEQVVTHVLATKPADVAALLESSFDGKTVKEHLDTANAALGEKIEIRRFAVLEGGYIGAYMHKTDPALPPAVGVLVQLDKPNAEVAKDIAQHAAAMAPQYLKAESVPAEVVEKERKLFEEMTREEGKPEAAIGKIVEGRVNGWYKDFTLLQQAFVKDNKKSVGKYAEENGVEVLAFVRFKVGQA
>NZ_CP017717.1|WP_080047179.1|7943642_7944449_-|UMP-kinase
MQDHRESAHESTRTAASSSQDPPAQSPQSPLRWKRVMLKLSGEAFAGSEPLGIDPTIVDHLADSIAEAVKEGVQVAVVVGGGNMFRGATLSQGGIDRARADYMGMLGTVINCLALQDFLERRGVETRVQTAITMQQVAEPFLPRRAIRHLEKGRVVIFGAGLGSPFFSTDTAASQRALEIGAEALLKGTQVDGIYDSDPRKNPDAVRFDHLDYGEVLLRDLAVMDATAISLCKDNDLPIVVFDLMGEGNILRAVRGEKIGTLVSPAGK
>NZ_CP017717.1|WP_080042323.1|7943041_7943599_-|ribosome-recycling-factor
MIDETLLEAEEKMDKAVSVAKEDFATIRTGRVTPSMFNKINAEYYGTPTPIQQLASFHVPEARMVTIQPYDKGSTNAIIKAIRDSDLGVNPTDDGQVIRVTFPELSEERRKEYIKVARNKGEHAKVSVRNIRRSAKETLDKMIKDGEAGEDEVRRAEKELDDLTQKHVAKIDELLKHKEAELLEV
>NZ_CP017717.1|WP_080042333.1|7958470_7960003_-|YifB-family-Mg-chelatase-like-AAA-ATPase
MAVARTRSVALVGVAGRTVEVEADVGNGLAGIHLIGLPDTALSEARDRVRSAMVNSNYPWPDARIIVSLFPASLPKRGSQFDLAIAVAILGAAGVVPAERIAEPFFLGELGLDGRIRAVRGVLPSVLGAAKHGDVTVVVPSGNSAEAVLVPDVKVIPVADLRQLVEWLRKGDEPPSVELEEYAEPPKSTVSPDVDLADVVGQPVARRALEVCAAGGHNLWMLGPPGTGKTMLAERLPTLLPDLELDHALEVTAIHSVAGVLPPNAPMMSRPPFVSPHHTATSAAIIGGGSTIVRPGAVSLAHRGVLFMDEAPEFPRHVLDALRQPLESGRVTVSRSAGSVTFPARFMLILAANPCPCAQAEDQGETCKCSPTIRRRYLGRLSGPLLDRIDMKVTVARSSRRELLADRQFVETSKTVAERVLVARERAAKRLAGTPWRSNAEVPSSVLHADYRPSDEAMHPMTACLDAGTLTARGLDRVVRVAWTLADLADKDTPGEDETNTALGFWLGVR
>NZ_CP017717.1|WP_080042334.1|7960003_7960363_-|YraN-family-protein
MAKESKQELGKRGEQAAATYLEAEGMRVLERNWRCRHGEIDILAEEGPTLVVVEVKTRSGRSHGTALESVTPAKLARLRMLAAKWLSGQSRTFESVRVDVIALERFAGDLALHHVRGAI
>NZ_CP017717.1|WP_026215037.1|7961480_7961804_-|DUF2469-domain-containing-protein
MSAEDLEKYETEMELQLYREYRDVVGLFTYVVETERRFYLTNSVDLDVRTAENGDVFFDVKMQDAWVWDMYRPARFVKNVRVVTFKDVNVEELAKADLEMPKEGFSG
>NZ_CP017717.1|WP_080042335.1|7961843_7962512_-|ribonuclease-HII
MTVAFRPRPSVVRRDSGLYAYERALARRGLTPIAGVDEAGRGACAGPLVVAAVVLRKQIDGLGDSKLLTPIVRERLYDQIVRAAHVGLVIIPPGEIDAKGLHKSNVSGMRRAVAQLPCDPEYILTDGFPVPGLPAPSLAVWKGDQVAACVAAASIVAKVTRDRLMVTLDERYPQYGFAEHKGYVTPGHRLALATHGPCPDHRYSFVTVAREMGENEMGAGVA
>NZ_CP017717.1|WP_080042336.1|7962564_7963158_-|signal-peptidase-I
MADTKKAEGVAKEKKKGGFRETVLLLVLGVGIALLLQAFVVGSFYIPSVSMENTLLVNDRVFVNKLAGKPERGDIVVFKGWNGEDTIKRVIGIGGDKVVCCDKQKRITVNGTPLDEKSYLYPDDFASGDDFNVTVPAGKLWLMGDHRSASADSRAHMEEPGGGFISENDVIGKAVLRYWPLSRGYLFSRPDIFDKVK
>NZ_CP017717.1|WP_080042337.1|7963157_7964018_-|signal-peptidase-I
MTSESQEHGAARRPVEDEVDVVAEETQKPAKGEKKEKKGSFWKELPVLIVVALALALIIKTFVVQAFYIPSESMENTLLTNDRVLVNKLVYHTRDIERGDVVVFSGVDSWDGEFQMAEPSNVVEGFFRWVGTAFGIIPGEKDYIKRVIGVGGDHVKCCDSKGRITVNGTPIDEESYLYPGDKPSDEFFDITVPQGRLWVMGDHRSVSLDSRSHTGDPGGGSIPEGQVIGRAFVIVWPFNRFDTIDIPDTFAQPALHAMGGTPVPLAAGFGLAVPLVLVRRRLRRRR
>NZ_CP017717.1|WP_080042338.1|7964160_7964523_-|50S-ribosomal-protein-L19
MHTKIQELEKATLRGDVPAFRPGDTLEVHVRVVEGNRSRIQVFKGFVLRRQGSGARETFTVRKVSYGVGVERTFPVHSPVIEKIVLVTRGDVRRAKLYYMRDLRGKAARIREKRETTAAK
>NZ_CP017717.1|WP_080042340.1|7965521_7966022_-|ribosome-maturation-factor-RimM
MQLVVGRIGRPHGVRGDVTVEVRTDDPELRFAVGTPVATDPADRGPLVVTGRRWHKGVLLLTFEGVTDRDAAEELRGTMLVIDSSEVTPSDDPDEFHDHQLIGLAVETVSGEAVGEVEDVLHHGQDLLVVRRKGQEDALIPFVRALVPEVDVEAGRLVVDPPEGLL
>NZ_CP017717.1|WP_043634919.1|7966091_7966337_-|RNA-binding-protein
MLEEALEHLVKGIVEHPDDVRVRARRIRSGRVLEVRVHPEDLGKVIGRGGRTAKALRTVVNALADGKYVRVDLLDLHEAVR
>NZ_CP017717.1|WP_080042341.1|7966338_7966779_-|30S-ribosomal-protein-S16
MAVKIKLKRLGMIRNAQYRIVVADSRTKRDGRAIEEIGLYHPKENPSRIEVNAERAAYWLGVGAQPTEPVLKLLKLTGDWQKFKGEPAPEPMKVAEPKADRHALYEAAAKEALSGGDTGTAATTPRKSKKKDEAEAPAETPSEGEA

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Crispr_ID: NZ_CP017717_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_21

8297805-8297910

Orphan

Consensus_repeat	Method
ACCCGTCAACGGCAGGAGCAGCCGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_21

>merge|NZ_CP017717|21|8297805-8297910|CRISPRCasFinder
ACCCGTCAACGGCAGGAGCAGCCGTCAGACGCAGCAACGCCCCCGGCCAGCGGCACCACGGCCCCTCGGCCTCAGAGACCACCCGTCAACGGCAGGAGCAGCCGTC

>NZ_CP017717|21|19|8297805-8297910|CRISPRCasFinder
ACCCGTCAACGGCAGGAGCAGCCGTC	AGACGCAGCAACGCCCCCGGCCAGCGGCACCACGGCCCCTCGGCCTCAGAGACC
ACCCGTCAACGGCAGGAGCAGCCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080047209.1\|8294293_8295451_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP017717.1\|WP_080042604.1\|8304741_8305428_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|378278
NZ_CP017717.1\|WP_080042589.1\|8289548_8290244_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|316740
NZ_CP017717.1\|WP_080042597.1\|8295614_8297489_+\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NZ_CP017717.1\|WP_155128478.1\|8302985_8303321_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080042606.1\|8305933_8306557_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|372627
NZ_CP017717.1\|WP_080042593.1\|8291590_8292181_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP017717.1\|WP_080042595.1\|8293138_8293384_-\|type-B-50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|234969
NZ_CP017717.1\|WP_080042596.1\|8293412_8294153_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP017717.1\|WP_080047211.1\|8306540_8307233_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379402
NZ_CP017717.1\|WP_155128474.1\|8298045_8299140_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|164795
NZ_CP017717.1\|WP_080042590.1\|8290260_8290965_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP017717.1\|WP_080047210.1\|8301148_8302771_+\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487
NZ_CP017717.1\|WP_080042591.1\|8290984_8291251_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155128476.1\|8299130_8299439_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080042603.1\|8304253_8304745_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|234860
NZ_CP017717.1\|WP_080042594.1\|8292187_8293135_-\|DUF1152-domain-containing-protein	unknown	unknown	gnl\|CDD\|377680
NZ_CP017717.1\|WP_080042592.1\|8291221_8291461_-\|DUF3040-domain-containing-protein	unknown	unknown	gnl\|CDD\|378610
NZ_CP017717.1\|WP_080042602.1\|8303328_8304141_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP017717.1\|WP_155128480.1\|8307336_8307945_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080047209.1\|8294293_8295451_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.99716e-43
NZ_CP017717.1\|WP_080042604.1\|8304741_8305428_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|378278	pfam09859, Oxygenase-NA, Oxygenase, catalyzing oxidative methylation of damaged DNA. This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.	3.43555e-117
NZ_CP017717.1\|WP_080042589.1\|8289548_8290244_+\|hypothetical-protein	gnl\|CDD\|316740	pfam14247, DUF4344, Putative metallopeptidase. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 247 and 291 amino acids in length. There is a conserved EED sequence motif. This is a putative metallopeptidase.	7.78256e-29
NZ_CP017717.1\|WP_080042597.1\|8295614_8297489_+\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP017717.1\|WP_080042606.1\|8305933_8306557_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	8.42638e-57
NZ_CP017717.1\|WP_080042593.1\|8291590_8292181_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.83555e-06
NZ_CP017717.1\|WP_080042595.1\|8293138_8293384_-\|type-B-50S-ribosomal-protein-L31	gnl\|CDD\|234969	PRK01678, rpmE2, type B 50S ribosomal protein L31.	6.49588e-50
NZ_CP017717.1\|WP_080042596.1\|8293412_8294153_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	8.71444e-57
NZ_CP017717.1\|WP_080047211.1\|8306540_8307233_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379402	pfam13936, HTH_38, Helix-turn-helix domain. This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	0.00280065
NZ_CP017717.1\|WP_155128474.1\|8298045_8299140_-\|hypothetical-protein	gnl\|CDD\|164795	PHA00370, III, attachment protein.	0.000165927
NZ_CP017717.1\|WP_080042590.1\|8290260_8290965_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.43442e-12
NZ_CP017717.1\|WP_080047210.1\|8301148_8302771_+\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	4.43668e-88
NZ_CP017717.1\|WP_080042603.1\|8304253_8304745_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|234860	PRK00901, PRK00901, methylated-DNA--protein-cysteine methyltransferase; Provisional.	1.34159e-51
NZ_CP017717.1\|WP_080042594.1\|8292187_8293135_-\|DUF1152-domain-containing-protein	gnl\|CDD\|377680	pfam06626, DUF1152, Protein of unknown function (DUF1152). This family consists of several hypothetical archaeal proteins of unknown function.	1.00817e-22
NZ_CP017717.1\|WP_080042592.1\|8291221_8291461_-\|DUF3040-domain-containing-protein	gnl\|CDD\|378610	pfam11239, DUF3040, Protein of unknown function (DUF3040). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	1.17998e-07
NZ_CP017717.1\|WP_080042602.1\|8303328_8304141_-\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	1.49273e-72
NZ_CP017717.1\|WP_155128480.1\|8307336_8307945_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	9.11513e-06

>NZ_CP017717.1|WP_080042597.1|8295614_8297489_+|DNA-helicase-RecQ
MDTPTEVLHRVFGYDSFRSGQQEIIDHVVAGGDALVLMPTGGGKSLCYQIPALVRKGVGVVISPLIALMQDQVDALRALGVRAGFLNSTQGFDERQLVESEFLAGELDLLYLAPERLRVDATLRLLGKGDIAVFAIDEAHCVAQWGHDFRPDYLELSKLRELWPEVPRIALTATATPATHAEISSRLGLDQARHFVAGFDRPNIHYRITPKSEPKRQLLDFLRTEHPGDSGIVYCLSRSSVEKIAEFLVEHGIAAVPYHAGLDARTRAHHQARFLREDGLIVVATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPATAWMAYGLQDVVQHRRMAMEGDDAHRRRQVQHLDAMLALCETVGCRRMMLLDYFGQKGSQPCGNCDTCQTPPESWDGTIPAQKVLSTVLRLLRERRQKFGVGQVVDILLGKKTAKVLQHGHDTLSVFGVGTDLGNAEWHGVVRQLLAQGLLAVESDYGALVLTDDSAAVLRGQREVRLRRDTHRPARAKTSSGTKPAQAAVELPAEAAALFERLRAWRGATAKEQGVPAYVIFHDATLREIATLAPTSLAELSKVNGVGENKLAKYGEQVLSTLHGDDATPPPAQQTLETPEEDDTLL
>NZ_CP017717.1|WP_080047209.1|8294293_8295451_+|MFS-transporter
MIGALAITQTAGYGILYYAFSVFIPPMSRELHAGVAQLTGAITLSVLVSGLVAPLIGRWLDRHGGRGLMTLGSVLGALAVLAWSQVRSVVQLYLVCGVLGVASAMVLYEAAFAVIVAWFDAARRARALLAVTVVAGFASSIFLPLTGLLVELYGWRRALVVLAVGYALTAVPLHGLAVRGRAAPAHVDRGEIVGAALRERPFWLLAAAFLTQTGAVAVMGVLLVTYLIALGHAPVFAAGVAGLLGVLSVTGRLVTTGLQARWPVALIAAAIFGLQGLAAVLLPLIGRDAFGAVVAVVLFGLGFGVGTIARPALLADRYGTAAYASLSGALALPITVAKAVAPLAAAGVAQVAGYPAVMGVVAVACVLGAVSLVLYARVRPAEATG
>NZ_CP017717.1|WP_080042596.1|8293412_8294153_-|SDR-family-oxidoreductase
MTLSYVVTGGGRGIGRAVVERLLGERDVVVVVERDKEALEWAGPRVVPVIGDAADEEVAAWAADLAQESGTLAGWVNNAAVFRDASVHSSPISEVRALIAANLDLAVVGCATAVRHFLEAGTPGAIVNVTSHQATRAVPGSLPYSTAKAATEGLTRALAVEYGRHGIRVNAVAPGSVATERYERQRTPEMAAELARLHPLGRVATPAEVASVVAHLLSPDAAFVNGATIPVDGGRTVLGLDPEARE
>NZ_CP017717.1|WP_080042595.1|8293138_8293384_-|type-B-50S-ribosomal-protein-L31
MKKNLHPAYRPIVFRDPSVGFAFLTRSTLTSDRTIEWEDGRTYPVVDVDVSSASHPFYTGRGRILDTAGRVERFKQRYGKM
>NZ_CP017717.1|WP_080042594.1|8292187_8293135_-|DUF1152-domain-containing-protein
MLDSPLSARLGRSRRILVAGAGGGFDVYAGLPLALSLREAGKEVHLANLSFSRLDALDLDVWLFEDVAEIRPGTEARDWYFPEGCLSRWLAAQGLPSTVYAFPKVGVRPLRAAYARLAEHLGLDAVVLVDGGTDILMRGDEAGLGTPAEDMVSLAAAHALDVPTKAVACLGFGVDAYHGINHVQVLENLAALEREGAYLGAFSVSRATRAGALYLDAVAHAQAELPAYPSIVNGSIAAAVRGEFGDVRFTDRTKGSELFVNPLMAICFAVDLDALARRSLYLDRLRDTVLMRQVVSEIEAFRDEVAPRPPKVFPH
>NZ_CP017717.1|WP_080042593.1|8291590_8292181_+|TetR/AcrR-family-transcriptional-regulator
MSTPRQRYREQVRREIKQAALAQIGAGEPLSLTAVARRLGMTGPALYKYFAGRDRLLAELIDDGLAELAAAVRAGSPAGGGPRARLHALARAFYDWALANRGLFQLVAAAPRRAGVEEVLGPFLPVLGQGRAVPGLEPPEWAHPPAGDRTAALTGAVLVWARLQGVLSVELRGPFTGTGRALLTAEIDSLADTMGL
>NZ_CP017717.1|WP_080042592.1|8291221_8291461_-|DUF3040-domain-containing-protein
MSLSGRERRILAEIERALERDDPELAKRVAAINRIEAGGDLPPQPYGDRLRMWALAHVWVLFWMAALVIVLLLLAVLTT
>NZ_CP017717.1|WP_080042591.1|8290984_8291251_+|hypothetical-protein
MWLRNRAGTEPVTARSPLRARRALSLAALVLGVVAAVFFAVQAMRTGQEVWRWEAAIAAAVAVIAAIDLVVLRRRRSGSSGRQHGQEQ
>NZ_CP017717.1|WP_080042590.1|8290260_8290965_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MADELLKDFNPFDIFDAEAARLDRFFSSLDDAGWQRPSRCDGWSVRDVLAHLAGEELYNHACLDGTVPDLMSRLAEEGIGGYNEFNEWCVRERAGLPVADVLAEWRTKNAETRERMRALGRDAVLDTMAGPYPVGHQTFHYDSEYATHADDVGAPVGEDESDGRTLWRVAVGRFVLAEQNAKVQVEQTAEQIFAAVDGLTATLSYPEFVEATVGRLPASHGLDPRIASALRCLA
>NZ_CP017717.1|WP_080042589.1|8289548_8290244_+|hypothetical-protein
MPHPVLALVLSMTSTLGAAPSPEPSVRYEPPASPRAEQAERLLKDTGALETDVRLPEPVKVVARDCEAPKATWDHGKREITICYSLVDQVQRTIKGISQTEETGEKAAEARVRGALSVLFHHQLGHALTTLNGMTDGEAQADEFAALTLVADTPKRVVAAAEARHLLAGHAGIDHLSGMEQSATFACLLYGSDPGAYSKIVKGGWVPPERAPSCAGEHDRVRSAIGDKVRT
>NZ_CP017717.1|WP_155128474.1|8298045_8299140_-|hypothetical-protein
MGLTLPPEYAEAAALVGLSAELFLWDEDQLERLAGTISTFLQDVEPGTQDLRQAATRFAAATGASGLTTGTGGVTGLASAAQGTAALASASGGSGGDTPGVNGAGGGTPGRDGAGSGAAGGNGAGGGTLAGNGAGGGTAGGNGAAGGVGGGSAAGDAFVSHWTAMAGAGGADDVLRAAGWTAAALGFAAMEIRAAKTVVLARLAWCARQLALSTLGGPAGRLAGIANVLASRVAIGEVVRELGRRLRDVAVPVVRRAIALLREAAGRLRGAADTLGTRLAGSTPRPAYAGLPGHAPALDGTRMNMGRKKDDDEGFSWLPKRNSNESHDKPGKSGQTCDYCGGSGDDPFKDGRTCPNCVGTGVNP
>NZ_CP017717.1|WP_155128476.1|8299130_8299439_-|hypothetical-protein
MDVDTAETSARQAVHGTSTYATAVARLRADLAAAGPVGAEGSDLAAAIEEFTGLLLDTADRTAQAYGSTAEGMSASVTAARSADSRATAPATALTPVPVSWV
>NZ_CP017717.1|WP_080047210.1|8301148_8302771_+|CocE/NonD-family-hydrolase
MLSRLIDRLLGLPEATVRDIEVVHDLRVPMPDGVVLRADRYRPRGSEPLPVVLVRTPYGKHKLDAKGTARVLARRGMQVVVQNARGTFGSGGRFSAFHQEKEDGLATAAWLREQPWCDGRLAMTGASYLGFTQWAVGPYLDPPLEAMCLGVTASEFRTTFYPGGVFALHNLLTWAALIGTQEEARLGGMLPGPRGERRLRRAMAHVPLGRSDVAAIGKEVPFLREAAAHSGAGDPFWTDVDNSAAAVKMTTPTSMVTGWWDLLLPAQLRDYAALREAGRRSRILIGPWGHDLGALRAFLAEEVSWLSAHLLGDTAQLQRSPVRLYLQRAGRWLDFERWPPPQSVPTPLHLLSYGRLGWSAPGESAPDTFTYDPAHPTRTVGGPLLDMRQGKQRDNRPIEARPDVLVYTGGPLPRDLDLIGPVSATVYVRTDTGHADVFVRLCDVDASGVSRNVTDGIVRLPAGSEGVVKAEVELHPTGYRFRRGHRLRVQVAGGAFPRFARNHGTGEPVAEAVRTRATRFEIFHDGTHPSSLTLPVFGGR
>NZ_CP017717.1|WP_155128478.1|8302985_8303321_+|hypothetical-protein
MLEGEGFPEVRGTARDAELWGLLFVKATPLSAGDEVKIVWRMTGEGPLRARAVHPDGTLARPVWGPEEHGSSTWRRPGQEWGTGFVFPKRGCWKVELSRDRGSGHVWLPVH
>NZ_CP017717.1|WP_080042602.1|8303328_8304141_-|alpha/beta-hydrolase
MAESRERTFTGTRGRNTAREWPHEQPRYLAILVHGYGEHIGRYEHVADRLVRHGAAVYGLDHVGHGKSEGDRALVEDFEDVVTDVHAVEEHARAEHPGVPVVLIGHSMGGMIAARYAQRYGSGLTALVLSGPVIGEWGAVPALLAFEEPPDVPIDPSTLSRDPSVGAAYAADPLVWHGPFKRATLESFAATLETIAKGGTFGALPTLWVHGDDDQLVPLAGSRAGIEAVKGSDLTERIYPGARHEVFNEINKDEVLDDVTSFIDRALPGA
>NZ_CP017717.1|WP_080042603.1|8304253_8304745_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MDIYTTIDSPLGEILLVGDGTALTRLSFAPAAPHTAGLRRDDLKFAEAARQLGEYFAGERTAFDLPLRPRGSTFQERVWTELAGLPYGTTTSYGALAARIGAPADRIRAVGAAVGANPLLVLLPCHRVVAADGALTGYAAGLERKRALLTLEGVLQPQLWSTL
>NZ_CP017717.1|WP_080042604.1|8304741_8305428_+|2OG-Fe(II)-oxygenase
MNADWNKLAAELDAYGCALTPPLLTREECEEISGLYDETAFFRATIDMERYRFGAGQYRYFDHPLPPLVQRLRAEFYPPLLPIARDWAARLGQPAPWPDDFGEWLDMCHRAGQTRPTPILLRYRENDWNALHRDLYGDLVFPLQVVIGLDRPGEDYTGGEFLLVEQRPRAQSRGTVTLLPQGHGLIFTTRDRPVRSSRGWSAAPVRHGVSTVRSGLRHTLGLVLHDAK
>NZ_CP017717.1|WP_080042606.1|8305933_8306557_+|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MREIAPGAVHVPGWLTLDEQRHLVQECREWARGPVPMRHTVLPSGGVMSVQTVCLGWHWRPYAYTRVAHDVNGRQVAAFPGWLADLGRRALADAYGRDVPYEPDTALINFYDGQAKMGMHQDKDERSDAPVVSLSIGDTCLFRFGNTETRGRPYTDVRLASGDLFVFGGPSRFAYHGVPKVYPGTGDPATGLTSGRLNLTLRVTGLR
>NZ_CP017717.1|WP_080047211.1|8306540_8307233_-|helix-turn-helix-domain-containing-protein
MKEQVRELRLQGKSPKEIARALKVSPSVVAPIVRAIAAETAEAAEAQGPGEAEVVGCWINVGWSEGLGLDPARGWVDEAPNSGVGGMVSVLVARRHTWDRLSVCGYLADVYCLGVKSVIGPDVLDDRDLVRFREYFFGEYPGWQEAPIELARHLVFGSVDYARKLGFEPHDLFALGSDLLGKWEEESAVTFGRDGKPFYVEGPEDDPARVVRTLRRTLSDDEFGYVTAGQ
>NZ_CP017717.1|WP_155128480.1|8307336_8307945_-|hypothetical-protein
MTENRSAQSPSGGGARSRTNWTAVSALAGTLAAVIALVAYLRPPPAPAQPPPSHSADVVESTPAATQPPATEPSTSPTPTAEPSTAEPPAVRPTQEAGGSAAPLSAVRPGGCDDAAAALAAYRRNAGSARSTQAAAAHQAYLDLMGAVLDAQGVVGQKISRLAAEFQELYFRLSGMNGGDPNQVITDINADMADLGTLCQPA

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Crispr_ID: NZ_CP017717_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_22

8447456-8447527

Orphan

Consensus_repeat	Method
CTGGTCGAGGGCTCGACCCTGGC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP017717_22

>merge|NZ_CP017717|22|8447456-8447527|CRISPRCasFinder
CTGGTCGAGGGCTCGACCCTGGCACCCCCGGCACAACGCTGACCCCGCACTGGTCGAGGGCTCGACCCTGGC

>NZ_CP017717|22|20|8447456-8447527|CRISPRCasFinder
CTGGTCGAGGGCTCGACCCTGGC	ACCCCCGGCACAACGCTGACCCCGCA
CTGGTCGAGGGCTCGACCCTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080042711.1\|8445665_8446307_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_080047229.1\|8447587_8449183_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_CP017717.1\|WP_080042709.1\|8444728_8445088_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_CP017717.1\|WP_080042704.1\|8440411_8441077_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|225512
NZ_CP017717.1\|WP_080042706.1\|8442271_8442811_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080042718.1\|8456305_8457271_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP017717.1\|WP_080042705.1\|8441073_8442066_+\|threo-3-hydroxy-L-aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|235918
NZ_CP017717.1\|WP_080042716.1\|8454133_8455087_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP017717.1\|WP_080042717.1\|8455166_8456195_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|225807
NZ_CP017717.1\|WP_080042719.1\|8458786_8459350_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378968
NZ_CP017717.1\|WP_080042715.1\|8452227_8454102_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181651
NZ_CP017717.1\|WP_080042707.1\|8442914_8443796_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017717.1\|WP_080042708.1\|8443910_8444675_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP017717.1\|WP_080042714.1\|8451394_8452225_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080047230.1\|8450565_8451405_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080047231.1\|8457300_8458704_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP017717.1\|WP_080042702.1\|8439097_8439970_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293835
NZ_CP017717.1\|WP_080042710.1\|8445108_8445666_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP017717.1\|WP_080042713.1\|8449202_8450462_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP017717.1\|WP_080042703.1\|8440035_8440422_+\|reactive-intermediate/imine-deaminase	unknown	unknown	gnl\|CDD\|129116

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080042711.1\|8445665_8446307_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.32844e-05
NZ_CP017717.1\|WP_080047229.1\|8447587_8449183_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	7.31684e-114
NZ_CP017717.1\|WP_080042709.1\|8444728_8445088_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	1.59339e-09
NZ_CP017717.1\|WP_080042704.1\|8440411_8441077_+\|DNA-binding-protein	gnl\|CDD\|225512	COG2964, COG2964, Uncharacterized protein conserved in bacteria [Function unknown].	1.49984e-50
NZ_CP017717.1\|WP_080047230.1\|8450565_8451405_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.57781e-81
NZ_CP017717.1\|WP_080042718.1\|8456305_8457271_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	5.96411e-132
NZ_CP017717.1\|WP_080042705.1\|8441073_8442066_+\|threo-3-hydroxy-L-aspartate-ammonia-lyase	gnl\|CDD\|235918	PRK07048, PRK07048, threo-3-hydroxy-L-aspartate ammonia-lyase.	8.83979e-162
NZ_CP017717.1\|WP_080042716.1\|8454133_8455087_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	8.20399e-111
NZ_CP017717.1\|WP_080042717.1\|8455166_8456195_-\|NAD(P)H-binding-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	1.45966e-20
NZ_CP017717.1\|WP_080042719.1\|8458786_8459350_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	5.62472e-12
NZ_CP017717.1\|WP_080042715.1\|8452227_8454102_+\|hypothetical-protein	gnl\|CDD\|181651	PRK09105, PRK09105, pyridoxal phosphate-dependent aminotransferase.	0.00165926
NZ_CP017717.1\|WP_080042707.1\|8442914_8443796_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.57619e-29
NZ_CP017717.1\|WP_080042708.1\|8443910_8444675_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.42732e-69
NZ_CP017717.1\|WP_080042714.1\|8451394_8452225_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	9.27112e-87
NZ_CP017717.1\|WP_080047231.1\|8457300_8458704_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.50036e-08
NZ_CP017717.1\|WP_080042702.1\|8439097_8439970_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293835	cd16277, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	7.25243e-103
NZ_CP017717.1\|WP_080042710.1\|8445108_8445666_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	8.93777e-18
NZ_CP017717.1\|WP_080042713.1\|8449202_8450462_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.14053e-54
NZ_CP017717.1\|WP_080042703.1\|8440035_8440422_+\|reactive-intermediate/imine-deaminase	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	2.30583e-34

>NZ_CP017717.1|WP_080042711.1|8445665_8446307_-|TetR/AcrR-family-transcriptional-regulator
MPDVKHFDPDAALEQVMRLFWERGADVTGIADVVQATGLSRSSLYATFGGKERLQAAALGRYLERRSRPVFDALAADRRGLPAIASFFEQLVAARCTGEHARWGCLVTNTHTGAGRELPEVRQVLDAHHAELRAAMRAALTVAAGLGQVRPGLDADAAAETLALLAYGVNLRSRAGADPGDLLAGVRAVLDGFARTVTETATEPVTDTVTEER
>NZ_CP017717.1|WP_080042710.1|8445108_8445666_-|carboxymuconolactone-decarboxylase-family-protein
MTEFRVYDESDAPEAARPMLAAAKKRMGFVTTLNGVMAESPELLAGYNALAEQFGRSSLPGPAKHVVWITASVENGCEYCVAAHSTLALRARVPAEVVEALRAGKPLEDEALEAARRLTHAMVSQRGWVDDAEVEAFLTAGYTRRHVLDIVLGVGMKTLSNYTNHLAHTPLDPAWQGQEWTRTAS
>NZ_CP017717.1|WP_080042709.1|8444728_8445088_+|helix-turn-helix-transcriptional-regulator
MRRAHHPETGEITLMGVMAALSDPIRVGLVRVLADGQERGWGELRAPVAKSTLSHHLKVLRDAGLTRTRQEGTRCFVVLRREELQARYPGLLPAVLAAAEDEDVGHQVAVSPSLQESSL
>NZ_CP017717.1|WP_080042708.1|8443910_8444675_-|SDR-family-oxidoreductase
MTTASTSRLRGQAVIVTGAGSGIGRAAALAFARAGAHVLAVGRRADALRQTADRHPGIATLPADITADGAAQEVIDAAAGRWGRLDVLVNNAGATTVMPLADTDARRVADLLALNVTAPSLLARAALPHLRAARGAIVNISSTYGHRPLPGAAHYAASKAAIEQLTRSWALELAADGIRVNALAPGPTESEALTAAGLPDAVVEQIKRDETAAIPLGRRGTPEEVAAWIVHLADPAATWITGQVLTVDGGLELT
>NZ_CP017717.1|WP_080042707.1|8442914_8443796_+|alpha/beta-hydrolase
MFDDFETGMIDVGETELYVRYGGSGSPLLLLHGHPRTHATWHRVAPLLAPHHTVVCPDLRGYGRSGKPPTTADHTPYSKRAMAADMVALMRELGHDRFAVAGHDRGSYVAHRLAADHPDVVTRLVVMDGIPIGEALARADARFAAAWWHWFFLGQTEKPAERVINADPDAWYRGTAEQMGREAYEDYRRAVHDPATVHAMCEDYRAGLTVDRAADDADRAAGRRIACPTLFLWSEKDDMVDLYGDPLAIWRTWATDVTGHSIGSGHHMAEEAPDEVAAALLAFLRPAAAPGAG
>NZ_CP017717.1|WP_080042706.1|8442271_8442811_-|hypothetical-protein
MSRWRYLRWWAAAFAAGLLSFLSLWLPGWFEGDGAVGCAGYGPLPSGLAALWSEVETIWLDLRQHVETTYGWFLPNGLPMAAVLVSGAAASRPGRRLATLAGLVAALLVTAVALHWALMAFSYFLLADCTGWEARLLPWMGWRLLMAAGYACTTVLLLAGVHARRAAPAQARLQAGPGA
>NZ_CP017717.1|WP_080042705.1|8441073_8442066_+|threo-3-hydroxy-L-aspartate-ammonia-lyase
MTNALPVTLDDVHDAAARLKGVAHRTPVLRSRTLDALVGAEVFLKCENFQRVGAFKFRGAYNAVSRLTPQQRARGIAAYSSGNHAQAVALAARELGSTAVILMPEDTPRSKREATAGYGAEVVTYDRYTGDRVAIGEALAAERGLALIPPYEHPHVIAGQGTAALELIEEVGDLDALLVPIGGGGLIAGSATAAKGLLPGIRVIGVEPEAGDDTKRSLAAGARVSIPVPRTIADGQAADIPGELTFSINKHLVDDVALVSDDDIRAAMRLAFERLKIVIEPSGATPLAALLAGRVERVPRRVGVIVSGGNIDARRFADLCAAAPPAQPAP
>NZ_CP017717.1|WP_080042704.1|8440411_8441077_+|DNA-binding-protein
MKREQDAILAALTPVVDGIVATLGSFCEVVVHDFRRPESSVVAIAGTVTGRSVGGSMSEIGMGLLARGDQASDQLNYVTRTKDGKLVKSSTMVLRDSAGTMFGALCVNLDITAVTQAHALIGELAGLAAPTGAPTTTFGDDIDSVVAAIVDAHQLDQGKPWAELGREERLELFRTLDERGVFAVRRAVPQVAARLGISRASAYSYLSQARSGSDTSQEQQA
>NZ_CP017717.1|WP_080042703.1|8440035_8440422_+|reactive-intermediate/imine-deaminase
MFFWRTHVDEHPYSTAFRSGDLVAVSGRLGVSEPGVLVPGGFDAECAQAFANLDAALRSAGAGRGDVIKVVAYLTDIADRSRLNAAYEGFFSPPRPARSCVGVASLPYGGAIEIEALARVREEPAGEA
>NZ_CP017717.1|WP_080042702.1|8439097_8439970_+|MBL-fold-metallo-hydrolase
MPADSWTAGDLVIQRIDETELPPQTGPWLLPDATPDLVSGEPSLRPGFADDRGTLRLTTHSFAITTGGLRVLVDTGIGNGKTRANPAWHDLDTPYLSRLAAAGHSPEDIDLVVLTHLHTDHVGWNTRPDGADWIPTFPNARYVTSRAEWDHWAAADMDEPRKAMFRDSVHPIRDAGLLDLADVPPQGVEVAPGVRLLPTPGHTPGHVAVSLGDGAALITGDCVHHPVQLRRPDITSCVDIDPRQAVETRRRLLASLAGTGTLLLGSHFPAPTGGLVERDGETFRLVPAAG
>NZ_CP017717.1|WP_080047229.1|8447587_8449183_+|FAD-dependent-oxidoreductase
MSADALVVGGGLGGVAAALALLRAGRSVVLTEEYDWLGGQLTSQAVPPDEHTWVERFGVTASYRALRDGIRRYYRDHYPLTERARAWRELNPGAGHVSKLCHEPRVAVAVIEAMLAPYRGSGRLRVLQPYRAVGAEVDGDRVTAVRLAHRDGGGEIVAVAPYVLDATETGELLPLTGTEYVTGFESQAETGEPSAPAAAQPMNMQAVSVCFAIDHVDGDHTIDKPASYDFWREYQPPFWGDRLLSWRCPSPRTLEIVERSFTPNPGDDPRLVEADQRVNPGDGNLWTFRRIAARENFVPGAYESDITLVNWPMIDYLEGPVIDVPDPDLHLARARELSKSVLYWLQTEAPRHDGGTGYPGLRLRGDVTGGADGLAQAPYIRESRRIRALTTVTEQDLSVAVRGDKGAVGYHDSVGVGMYRIDLHPSTGGDNYIDVACSPFEIPLGALIPQRMTNLLPACKNIGTTHITNGAYRLHPVEWNAGEAAGALAAFCLERATTPHAVRADERLLADFQHRLVRDGVELRWPDVTGY
>NZ_CP017717.1|WP_080042713.1|8449202_8450462_+|extracellular-solute-binding-protein
MKAPLAALTLAALLAVSACGGGARDTGAAQGPQPLRMSIWTSNEAHLKLFKEIAAEYRKAHPQVGEITFDPIPFETYTTTLTTQIAGGNAPDLAWIMENSAPDFVGSGALVPLKSRIENVGELVPSATRLWEQGGELYAYPFSTSPFGVFVNTDLVKAAGQKTPRELMKAGQWDWEHANAINKAVAAKGGNGLTILNFDYKAWDNLATVWQGWGAKAWSDDGGTCRFNAPEMVEAMTFLHKAIFTDKSMPGPGTAVDFFSGDTAMAVAQISRAAMLEDATFKWDLVPLPAGPKGPYAVIGQAGIGVLKKSPRAEQATDFLAYFANAANSAKLAAYFPPARSSLLTAATMAKTSSMLNGDQLQEVVIDGIEKGVVKPSHTGQAELAQTARAALDPLWKPDADVKAVLDGVCAKIQPLLGG
>NZ_CP017717.1|WP_080047230.1|8450565_8451405_+|sugar-ABC-transporter-permease
MISPQLAGSVLFVLLPLGLVVYYSLQEWNVLAGTFEYVGGANYAKLLADPNMGQVLASTALFSAGLVVLNLTLALVLAILLDQRLRGTTFFRTLFFSPVLVSLVAWTIVWQFLLQQDGGVNGLLGLAGVEGPNWLRGDTTALLSVVVVQVVKNVGLNMVLFLAALQGVPRQLHEAAQLDGAGAWTRFARITVPQISPTILLTSIITVVGSLQVFAQIAVLTQGGPGLSTTVLVYYLYQQAFQFRHLGYGATLSVLLFLIVAALTLLQWWLRRKWVFHES
>NZ_CP017717.1|WP_080042714.1|8451394_8452225_+|carbohydrate-ABC-transporter-permease
MSRRVKLALYALLCVLCVPFVFPTWWMVTSSVKPISDIFAFPPALIPSRFDFSTYSRVFELQPFGQQYLNSLYIAAVVTAGTMAVAAMAGYAFARIRFPGQNLLFLVVLVGLLIPSEVTIVPLFQLFHAAGLTDTHWPLILVPILGAPGVLATFIMRQFFITLPGELEEAARVDGLGRFGTFRKVALPLARPALGAVAIFTFLHSWNLYLEPIVFLSTPSKFTLPQALTQFVDAYGSPLWNVQLSAATMTALPILVVFVLAQRQFIEGLAHTGLKG
>NZ_CP017717.1|WP_080042715.1|8452227_8454102_+|hypothetical-protein
MHTPHLSRRSLLRAAALLPAAAPVLLPAALPDLAPLPSGAPDRRLFAPHEQRFAPYLATLAPMVNDMDDSGFFAGGWWRNPAAPYNARVQEHVFTLAWFHANARPWNPYAGDASLLAALDAALGHYLSLQHADGSFPEYSRDQHGLAPTGFGIGYLAKTLRILRATGALPARQAQISAALRTAMTWFLDGGNRTVWQERLTWANQTSAGLAGAALALRLDPDPALSARLTEAFARIATAGLSTAGFFNEEGGHDMNYNFEVMLPELADAHHQNPDPHLVDMARAFTGFLSYNLLREPDGAGYLVNVAPSTRTSTRWYDEVRPDPDRTALNWTFTRQVPLLSAFMTAREDLAEARAAWAAAPDPVTPLAKQDTSPRILTHALDGERFPTRMQRAAAIADLPYLRSADFAELRRDNGQDFLYVRKPGLYLGGYFGTRASRARTGLTFLWHPEAGTVVCGLNDNNHACWATVFPGQVPDANGSLPAAYFHGAPSDGRQWTGGRAPAALGIRYGNASVTTDVLITSRTVRRTVTANAAATEQIPLVLHPSDVLTFTDGTRAAFGGATTATADGFDVRRGRTTIRFRWGTPLEATLAAGTVRYFRDGSRRFHALRVPHQGRFDLTVTMG
>NZ_CP017717.1|WP_080042716.1|8454133_8455087_+|helix-turn-helix-domain-containing-protein
MHTVAVLALDQVIPFDLSVPIETFARTRLPGGHPAYRVRVCGERPEVDAGAFTVRVPGGLDELRAADTVIVPGVSDPFAPLPGGVRDALRAAAANGARIASICSGAFPLAATGLLDGLRVTTHWVLAERLAAAYPLLEVAPDVLYVDNGQFLTSAGAAAGLDLCLHLIRRDHGSAVAADAARLSVMPLEREGGQAQFIVHDHPVVPRGSELEPLLGWLQDNLAGPLTLDDISAHAGMSTRTLIRRFREQTGTTPLRWLHRARIRQAQHLLETTRQPVERIGAQVGFGSPTAFRDRFKRMTGVSPAGYRRAFGSKAAT
>NZ_CP017717.1|WP_080042717.1|8455166_8456195_-|NAD(P)H-binding-protein
MAAGQMVAVFGAYGHTGRFVVARLLERGFVPVLSGRDAGKLKEQAYESGLEARPASVDDPAALDRALAGTAAVINCAGPFATTGAPVIEAALRAGIPYVDVAAEIEANVDTFTQFAGRAREQGAVVVPAMAFYGGLGDLLATAAMGDWTAADEAHIAYGLSDWHPTAGTRASGVISRQRRDGRRVRYAGGRLEYRDDQSPTLEWPFPEPMGPRAVIGEFSMADIVTVPSHLAIPEVRTYMTVEAAKDVVAPDTPAPAPADEKGRSAQTFLVDVVVRAGGSERRAVATGQDIYAITAPIVVEAVERILSGRTRAVGVVSAGEIFDAPDFLRALSPHLTVDLHG
>NZ_CP017717.1|WP_080042718.1|8456305_8457271_+|helix-turn-helix-domain-containing-protein
MHTVALAVTDGMLHFELSLAYEVFGADLTHLADPWYDLVVCGPGAVRAGRFLLEPDHGLDHLREADTVIVPGWADVDVSPPAELVAAVRAAHEAGARVASLCTGAFVLAEAGLLDGKRATTHWAHTRELATRFPEVEVDPDVLYVDNGDVLTSAGKAAAMDLCLHLVRLDHGSSVTNAVARRLVVPPHRDGGQSQFVTTPVPAPDNHPLAELFPWVMERLDQPLTVEDLARQARMSARNLGRHFRSVTGTTPLQWLLIQRIRHAQQLLETTDDSVDAIASATGMGTATTLRRNFNRTVGVPPDTYRRTFRSRTRPGALTHA
>NZ_CP017717.1|WP_080047231.1|8457300_8458704_-|prolyl-oligopeptidase-family-serine-peptidase
MKLLAAILAVLFALPLPAGATAPPGLPADLTSTEVSFRGEGGLELHGSVISPANARAGRPGVVLVHGAGTGTPREKLLAEAVGAARQGLSVLIYDKRSQGYSTTERSYPQLAEDALGAVATLRRQPGVDPAKVGIWGLSEGGWVAPLAATRPSSGIAFVIVVGANALSPLRQQAWAVAAGLRKAGAGGSLVGRAEPNLYRVIADGGLFPEPYHDPEPVLARVRQPVLAIWGVHDLLTPPRETPPLFADALEAGGNRRYTFRFFPQADHAAHLTPDGGVTRLPELAPGYAELVGTWVGEATSGRAPVAQVSGPAPVQAVDSFGVPPTAWWESAAMQVVALVLLLVAFGGYPVVALVRRVRRRDAGVPSVAARVISAGGLVAILGGFAYLFYVIMTGGKLAAPGPMLGDRPVLWLALQAVAVATVAATAVTVATWRRAGTRGERVRLGLLIAGGAVFVPWALYWGLLLP
>NZ_CP017717.1|WP_080042719.1|8458786_8459350_+|helix-turn-helix-domain-containing-protein
MKDDEPYLLDDPDRLKALAHPMRRAMLTHLNVHGPATSTTLGELLGAKTGTTSYHLRQLEKYGFIEEIPERSTGRERWWRRAKVPRDLRLPTPDQVAPEDRAVLEEFHRVGYEEDRALFERFPAAYRADPGWARGSRGLARMTREELDAFYEEYIALLLRYSRPADEAPPDARPVHVRLFTLPADES

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Crispr_ID: NZ_CP017717_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_23

8942417-8942590

Orphan

Consensus_repeat	Method
CGGCCTCGCGGGCGAGCAGCCTCG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP017717_23

>merge|NZ_CP017717|23|8942417-8942590|CRISPRCasFinder
CGGGCTCGCGGGCGGGCAGGCTCGGGGCAGCATGCCATGCAACGGCCTCGCGGGCGAGCAGCCTCGCGGGTCAGGGGCGGGCAGCACTGGAGGAGCTGGCGGCCTCGCGGGCGGGCAGCCTCGTGGACGCAACCCAGCCTCGCGGGCGGGCAGCCTCGCGGGCGGACGGCGTCG

>NZ_CP017717|23|21|8942417-8942590|CRISPRCasFinder
CGGGCTCGCGGGCGGGCAGGCTCG	GGGCAGCATGCCATGCAA
CGGCCTCGCGGGCGAGCAGCCTCG	CGGGTCAGGGGCGGGCAGCACTGGAGGAGCTGG
CGGCCTCGCGGGCGGGCAGCCTCG	TGGACGCAACCCAGCCTCGCGGGCGGG
CAGCCTCGCGGGCGGACGGCGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043083.1\|8941992_8942250_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP017717.1\|WP_080043082.1\|8941234_8941894_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|282131
NZ_CP017717.1\|WP_080043081.1\|8939734_8941204_+\|glutamate--cysteine-ligase	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043080.1\|8938114_8939110_-\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|224012
NZ_CP017717.1\|WP_155128593.1\|8935011_8935830_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043090.1\|8949368_8950085_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP017717.1\|WP_080043088.1\|8947627_8948779_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223717
NZ_CP017717.1\|WP_080043089.1\|8948809_8949277_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP017717.1\|WP_080043078.1\|8935953_8936835_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043079.1\|8936903_8937671_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043093.1\|8950994_8951714_-\|PIG-L-family-deacetylase	unknown	unknown	gnl\|CDD\|225031
NZ_CP017717.1\|WP_080043087.1\|8947034_8947478_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|378058
NZ_CP017717.1\|WP_080043074.1\|8930733_8932359_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377072
NZ_CP017717.1\|WP_080043076.1\|8933566_8934748_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP017717.1\|WP_080043085.1\|8945922_8946279_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319911
NZ_CP017717.1\|WP_155128597.1\|8950531_8950960_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350322
NZ_CP017717.1\|WP_080043086.1\|8946375_8946987_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319914
NZ_CP017717.1\|WP_080043084.1\|8942717_8945777_-\|ATPase	unknown	unknown	gnl\|CDD\|226418
NZ_CP017717.1\|WP_155128595.1\|8950328_8950550_+\|DUF2191-domain-containing-protein	unknown	unknown	gnl\|CDD\|378324
NZ_CP017717.1\|WP_080043075.1\|8932687_8933563_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080043083.1\|8941992_8942250_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	2.32912e-24
NZ_CP017717.1\|WP_080043082.1\|8941234_8941894_+\|hypothetical-protein	gnl\|CDD\|282131	pfam04228, Zn_peptidase, Putative neutral zinc metallopeptidase. Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	4.61412e-20
NZ_CP017717.1\|WP_080043090.1\|8949368_8950085_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	5.51232e-09
NZ_CP017717.1\|WP_080043088.1\|8947627_8948779_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	4.15536e-40
NZ_CP017717.1\|WP_080043089.1\|8948809_8949277_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.73736e-08
NZ_CP017717.1\|WP_080043080.1\|8938114_8939110_-\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|224012	COG1087, GalE, UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane].	8.07569e-114
NZ_CP017717.1\|WP_080043093.1\|8950994_8951714_-\|PIG-L-family-deacetylase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.39604e-45
NZ_CP017717.1\|WP_080043087.1\|8947034_8947478_+\|DUF1801-domain-containing-protein	gnl\|CDD\|378058	pfam08818, DUF1801, Domain of unknown function (DU1801). This large family of bacterial proteins is uncharacterized. They contain a presumed domain about 110 amino acids in length.	3.20123e-09
NZ_CP017717.1\|WP_080043074.1\|8930733_8932359_-\|hypothetical-protein	gnl\|CDD\|377072	pfam03595, SLAC1, Voltage-dependent anion channel. This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.	0.00566202
NZ_CP017717.1\|WP_080043076.1\|8933566_8934748_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP017717.1\|WP_080043085.1\|8945922_8946279_+\|glyoxalase	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	9.63609e-17
NZ_CP017717.1\|WP_155128597.1\|8950531_8950960_+\|PIN-domain-containing-protein	gnl\|CDD\|350322	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC3 and VapC21 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.60189e-40
NZ_CP017717.1\|WP_080043086.1\|8946375_8946987_+\|glyoxalase	gnl\|CDD\|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.19552e-15
NZ_CP017717.1\|WP_080043084.1\|8942717_8945777_-\|ATPase	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	6.46172e-59
NZ_CP017717.1\|WP_155128595.1\|8950328_8950550_+\|DUF2191-domain-containing-protein	gnl\|CDD\|378324	pfam09957, VapB_antitoxin, Bacterial antitoxin of type II TA system, VapB. VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC, pfam05016. The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the Toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all antitoxins.	3.36984e-05
NZ_CP017717.1\|WP_080043075.1\|8932687_8933563_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0

>NZ_CP017717.1|WP_080043083.1|8941992_8942250_+|WhiB-family-transcriptional-regulator
MPPEEISWLRRGACRSSDPDLFFPLAPTPLQEARAKAVCATCQVLEECRSYALRAGESEGIWGGLTPDERRRTRFPEGWRRPAAS
>NZ_CP017717.1|WP_080043082.1|8941234_8941894_+|hypothetical-protein
MTRALPPITRLLAGLLAVALVAACGVVRAPSMDRRGADSFEDDVVTARTLTEQFWSRQFQQLGRTYRPISDFIPYSGSAGPSCGDEPAVPNNAFYCPLGHFIAFDQGWMEGLWSDMGDGSVYVIIPHELGHAVQAQLRTGFTLNVQMELQADCYAGGTLSALVDSGALTTEPGDENELIRSLAAAGDPTDDWLNPAAHGTAEQRQASFARGYQDGVGAC
>NZ_CP017717.1|WP_080043081.1|8939734_8941204_+|glutamate--cysteine-ligase
MGRDVPVVVFSREDRRKYREKVHRCLDVFAQMLRESRFEFERPLAGLEIELNIVDSDGEAAMRNAQVLAAIAQPDWATELGQFNIEINIEPQDLAGDGALRLEHDVRARLNHADERARSEGGHLVLIGILPTLRERDITEGTLSANPRYRLLNEQIFAARGEDLHLAIEGVERLDTHADSVAPEAACTSVQLHLQVSPETFAAHWNAAQAIAGAQVAVAANSPYLFGKELHRETRIALFEQATDTRPAELKTQGVRPRVWFGERWITSVFDLFEENVSYYPALLPLCDDEDPRAELERGRVPHLHELTLHNGTIYRWNRPVYAVVDGVPHLRVENRVLPAGPSVADIAANAAFYYGLMRVLPYDERPIWSQMSFKAAEDNLAAAARHGLDARLYWPGLGEVPAAELILRRLLPMARDGLAKWGVHGHVADRLLSVIEGRCLTGRTGASWQVERVRAQAGSGDRHEALRGMTLEYIERMHTNEPVHTWDV
>NZ_CP017717.1|WP_080043080.1|8938114_8939110_-|UDP-glucose-4-epimerase-GalE
MRVLITGGAGYIGSTIASACLDAGIDPVILDNLVTGRREFAEGRLFYEGDISDGPLIDKIFAENPDIEAVIHCAALIVVPDSVADPIGYYRANVTKSLEFVDHLIRNGRTRMIFSSSASIYQAGPDHTVTEESPLDPQSPYARTKAVCEGMFADISASRPIRILSLRYFNPIGADPQMRTGLQLRRPSHALGKMIEAYEERVPFRITGTDWPTSDGTGIRDYIHVWDLATAHVAALRRFDELDTDVINLGTGAGTTVRELVDAFNRVVDRPIEVVEAPARPGDVAGAYTRSDLAHRLLGWQARYSVEEGIRHSLEWAALRDSRLEPADGAA
>NZ_CP017717.1|WP_080043079.1|8936903_8937671_+|hypothetical-protein
MKKALAVAAAAATLLSAAPAQAATPDPVRAVRQQFVAGHGVKFSETLITESKGDKEKFVQISGTYAFGPSGVVASEGTFRERLTKDKTTLHFRTVGRRLYLKGDNLPEGKTWMRVDDDAFKTPLTLQPVDILRLPQLKGLLSHTTSVRNGAYRGSVTAKQARELGGDRAPAGYDFRLSTDSSGLPTHLRTQEIADRTTVSVYDDTRYSAWGHKVTITDPPDHEVIDMDDIADSTFDETLEEILDLADNAVAAGRR
>NZ_CP017717.1|WP_080043078.1|8935953_8936835_+|hypothetical-protein
MKRILTGVALATTAALVTATPALAAAPKDPVVAVKKQLVPGKGVKFTERTTISDGDTREVFARRTGTLQFSKSGIAASDITGKLNIKASDLEGLDESGENADLTTLLKAMAQPERTIRIGTTSYMSGNIWATMMPEGKTWFKAPNGPTGGLLGTFSQPLNLAEPATIKTLLKGAKTTGSGYAGKTLVRDLWKASPWLRATWTAKPSAKAMKSAISWRITVNGAGLPTRLVTTFPMAVLGAGGKGSVSVDTSYTGWGSAVSIKAPPADEVTSTFKDGEDDISEALDLPLGSIAG
>NZ_CP017717.1|WP_155128593.1|8935011_8935830_+|hypothetical-protein
MLKETRMKRILAGLTLASSAALMAATPAQAAPVNPVKALKKQYVAGHGVRISETSRAATNGKTVQATTTTGSLEFGKSGVVATDLRTKEKGGLAGISPTRMITVGKYAYAQGGIYSEGLPEGKTWVRYPNDPPMRTSNQPLDVFNSKLLKTLVAKAKSFKGGTYRGVLTFSELGKVYGEKIDKRMGKIKINYALGVNSKGLITGIRSDYVMDFGVLGKTSATVNTRYTGWGAKITVKAPPSDTVVDYSELGTDTDVPQEIPNGSLNSLGRVQ
>NZ_CP017717.1|WP_080043076.1|8933566_8934748_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEHQAKELFADYGIPVPRGIVAHTVEEVRSAAEELTGRVVVKAQVKTGGRGKAGGVKVADDAADAVAKAEAILGMDIKGHTVHKVLVEEASAIAEEYYFSFLLDRANRTFLAICSASGGMDIEEVAHTSPEKVAKVPVSALTGIDRAKAREIAVAGGLPEKALDGAAELIEKLWCCFVDEDATLVEVNPMILSADGQVKALDGKVTLDDNAGFRQTDHEALADKAAEDPLEAKAKEKDLNYVKLDGNVGIIGNGAGLVMSTLDVVAYAGEAFPGKPSPANFLDIGGGASAEVMAAGLEIILSDPSVKSIFVNVFGGITACDAVANGIVSAFKLLESRGEAVTHPLVVRLDGNNAQLGRQILADAALPRVELVDTMDEAAKRAAELAAVGA
>NZ_CP017717.1|WP_080043075.1|8932687_8933563_-|succinate--CoA-ligase-subunit-alpha
MAIWLTENSKIIVQGMTGGEGTKHTRRMLASGAKVVGGVNARKAGTTHEGLPVFGTVKEAMEATGADVSVVFVPPKFTKDAVKEAIDAEIPLCVVITEGVPVHDSTEFWAYAVEKGNKTRIIGPNCPGIASPGASNAGIIPADITTAGRIGLVSKSGTLTYQLMYELRDFGFSTAVGIGGDPVIGTTHIDALQAFQEDPDTDAIVMIGEIGGDAEERAAAYIEQHVSKPVVAYVAGFTAPEGKTMGHAGAIVSGSAGTAQAKKEALEKVGVRVGKTPSETARLMREIMQAR
>NZ_CP017717.1|WP_080043074.1|8930733_8932359_-|hypothetical-protein
MTAILDQLRTGPRSMLGKLSGDDDDTRRPLPVSGMLAAVFTLGVGLAALTTLTLVGWIAAPRGTLGAGLPGVFRTAAQLWLAAHHAGFAIPGGRVGLLPLGLMILPAVLLYRAGRWMARDADLRLRLPARLPKNSPKEQAGARRRAQLVLVVQAGVSLAAPYALLAGLIALVASNEITQPFIGEALLSHFVLAFLAGSLATARMIGPWRVMLRLLPERVRALTVGTAVATALLLVAGFGLVLLAVVLNFDQVRGLSEVLSPGFVGGVLLALLQLLYLLNAVVWAFSYIAGPGFAIGADTLVAPTGVQLGTVPSLPLLGALPESGPVPAWMMAVVAIPFAAGAVAGVMVARISPSPSYEAAPLWGFLTGVTTGLGAGVLAALSGGPMGGGRLATVGPSPWEVALSVALEVGVAAGISAGVTNLLLLNKRARVPLDKAAAPVRKAGAALAKAASKVGLAESDPRPLPGHWMDATEADTQEIPVIRDDWQDEHASAEAETQAQARPRLVEPAPAARPPRKDIVDESDDRGGHVIYVDPYAWDRD
>NZ_CP017717.1|WP_080043084.1|8942717_8945777_-|ATPase
MGATQAIGQTGTVLAAVDISPREAEVLKLVGAHLSNAEIGARLCISVRTVESHVSSLLRKLDVPDRRALAQRAPEPAAGAAPSHPAPVLPSLLTSFIGRASERAELAEMLRTHRQVTAAGPGGVGKTRLALAVAAEAAGDYPDGVWFVDLVPVTDPGMAATAVAGALGLGEQPGRDMTESVVAALADRHALLVLDNCEQVADGVALFLERLLAACPRVTVLATSRARLMVPFERVYAVPPLSLPADGGSDAVTLFMERAAAVGRPVDPALRDQIAAICERLDGMALAIELAAARYSTLGLDGITAALSHPLRMLTGGSRADQRHRSVRAALDWSHALLEPADQALLRRVSVFAAPFTAAAAAEVTGDDEGLVIDGLARLAEQSLLVVSASPAGTEYRALETIRQYGTERLTEAGELADLRSRHLRWCLRRAAALAVVGEDWRPRFDQVADDLRAALAWAADQPERRGEAYELARSLAELTFTRNLIGESQRRHEQAAALAENPGSAALSLRHAAVVAGCRMRGDDLFRLRRAAADAARTAGDPAGAATDLAIAATATFRFATTFVQLPAPAEVLALIDEARTLAGTDPAAQAAVATAGAGWTLDAAVTGGQQPSAAARTPNPEPNTPAPQNPPASPPKAPNAPIPPTNSADPARPADPTEPAESAQPAGSAEPVPFAQFAQPAQPAPEEADGSVPETIVRAERAVELTHRTRDPLAESTALDVLTGALSWAGDTYAAAATTQRRITLLTSAPETPAATHELIEALGEAAEASLGTGDLPAARRWARRLAEHPLLAEVGHRATNWLLVTDALAGNVDEVLANSVRFLDAWQRAGSPAQSYLGRAVAAVAMVHGLRDDHDAQREWQGVLERLGPLPAHTYGYGPIFDAILLLHRGRPAEALERMAPEPAQVWKWVTWIWHHWYVALRTEAAVLAGSPAARDYVTETRKIVAGNPVAGAIVDRAAALLDGDQQSLLATAAAFETAGCRYQSARTLVLAGTDHAEQGAAILTNLGLAPMAPPR
>NZ_CP017717.1|WP_080043085.1|8945922_8946279_+|glyoxalase
MTGSSTQGIKTVLHPVSDLARSKAVYAALLGIAPQVDTAYYVGFETEGQHIGLVPDGGPQGMTSPVAYWHVHDIEATLAEVTAAGGTVKEAVHEVGAGRVVATVVDPDGNVLGLLQDR
>NZ_CP017717.1|WP_080043086.1|8946375_8946987_+|glyoxalase
MTAFASVTIEVSDLAAAQAFYQAVGLARYVNVRVSDEPTTGFRGFALSLVASQPGDVDALMTAALDAGATTLKPATKSFWGYGGIFRAPDGTICKVASSSKKDSGPAARRIDQVALLLGVADVKASKRFYVEHGLAVGKSFGGKYVEFDTPSSDVKLALYPRRALAKDTGLPQEGSGSHRIVLGGDSGSFTDLDGFVWETASA
>NZ_CP017717.1|WP_080043087.1|8947034_8947478_+|DUF1801-domain-containing-protein
MSSDTYQGFTAEERAAMKEHAKDQKKAARHASAAEKAAEAARDVLAKIAEMQGSDRVAAERVHAIVLANAPSLAPRLWYGMPAYALDGKIVCHFQPSTKFKTRYATLGFSDQASLDDGTMWPAAFALTEVTPEVEARIGELVRRAVN
>NZ_CP017717.1|WP_080043088.1|8947627_8948779_+|NAD(P)/FAD-dependent-oxidoreductase
MRRVDVLVVGAGLAGLRTAGLLARRGLDVLLVDRRRSLSAGIRTTGIFVRRTLDDFDLPDRLLGPGIRDVLLYPPSRRAPVRLTSDRDEYRVADMAGVYEHARHAAEEAGAQVLLGVRYTATTRSAGGGAGRRAVWLAGAEPVMARFVVGADGARSRVASDLGLDVNRRFLVGAEIVHPIAPGRGAPAFHCVLDPRIAPGYLGWVVDDGRHAHVGVAGYPEAMRSGVRHLLEVFAEDAPGHAPPTGPVERRGGPIPVGGVLRRLACPAGLLVGDAAGAVSPLTAGGLDPCLRMSELAATVTAEWLRTGDEGVLRQYDGNALRARFRGRLLLRRAFAGLRSPAAVEAAVAGLRGRAGRGLAARVLFGDGSFPDVPLKPALTPGR
>NZ_CP017717.1|WP_080043089.1|8948809_8949277_-|flavodoxin-family-protein
MPPAVRRLLIVHHTTSPTLQELFEAVRSGATTDEVEGVETVTRAALRATAVDVLECDAVILGTPANIGYMSGALKHFFDTVYYPCLEETRRLPYGLYVHGNNDTGGAVRAVESIAAGLGWERAHLPVTVTGTVSKDDLTACWELGATVAATISPV
>NZ_CP017717.1|WP_080043090.1|8949368_8950085_+|CPBP-family-intramembrane-metalloprotease
MLLRSIAVLTAANIMNNKIAPRLGPLTSAVATAALVAMARRAGVSWEELGFEHGRRGAVAGGVLAAAVAAVYTGGVALPRTRPLFHDDRALSLSRARVLEEALLQVPLGTVLLEEVGFRGALYGMLRREHGTATATAVSSGLFGLWHILPAIDMARANPALGALTAGESPGRLDTARVVAGSVVSTAAAGVLFCELRRRRGLLTPVMLHLATNSFGYAFARIAAKLPSGAPQKGHHPK
>NZ_CP017717.1|WP_155128595.1|8950328_8950550_+|DUF2191-domain-containing-protein
MRTVIDIDKELLEAAQQTLGTPTTRETVHAALRAVAGKDADRAGARAFAFWRTEGSPDLLDPETTKPAWRRRD
>NZ_CP017717.1|WP_155128597.1|8950531_8950960_+|PIN-domain-containing-protein
MATTGLMYLLDKSALARIRVSDVIARALQPLFAARAVATCSVVDLEVLYSARDYAHYQRILHAQRQCVLLPLDEEVQARAMAVQRQLVEISQHRGIGPNELLIAACAEVHGATILHYGHAFDIISEVTGQPSLWVVPPGSVP
>NZ_CP017717.1|WP_080043093.1|8950994_8951714_-|PIG-L-family-deacetylase
MLPESEINRVLVVTAHPDDADFGSAGSVALFVDKGVEVTYLLVTDGDAGGNERTLDNSGMAELRRKEQLAAAKAVGVTDVRFLGYPDGQVVPSLELRRAIARVIRQVRPDLVITHHPDRNYQFIAPSHPDHRAVGGATLDAVYPDARNPYAFPELIKEEGLEAWTVREVWLNGGSTPNHWVDITESMDRKLAALQSHVSQVSHVEGFTDFVRSRFAAWAEQAGLGEGRYAEGFQVVPTA

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Crispr_ID: NZ_CP017717_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_24

9058255-9058480

Orphan

Consensus_repeat	Method
GCCCNGGCAACGGCGGCCC	CRT

4 spacers

The CRISPR arrays of NZ_CP017717_24

>merge|NZ_CP017717|24|9058255-9058480|CRT
GCCCCGGCAACGGCGGCCCAGGCGGCGCCCCTGGAAACGACTTCTTCGGCAACGGCGCCCCCGGAGCCGGCGGCCCTGGCGGCGACTTCTTCGGCAGCCCTGGCAACGGCGGCCCGGGCGGCGACTTCTTCGGGAACGGCGGCCCCGGCAACGGCGGCCCCGCGACCGGCAGGCCCGGCGCAGGCCCGGACGGACCCGGAGGCGGCAGACCGGGCGGAGGCGGCCC

>NZ_CP017717|24|2|9058255-9058480|CRT
GCCCCGGCAACGGCGGCCC	AGGCGGCGCCCCTGGAAACGACT
TCTTCGGCAACGGCGCCCC	CGGAGCCGGCGGCCCTGGCGGCGACTTCTTCGGCA
GCCCTGGCAACGGCGGCCC	GGGCGGCGACTTCTTCGGGAACGGCG
GCCCCGGCAACGGCGGCCC	CGCGACCGGCAGGCCCGGCGCAGGCCCGGACGGACCCGGAGGCGGCA
GACCGGGCGGAGGCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043211.1\|9055607_9056132_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP017717.1\|WP_155128615.1\|9056987_9057671_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349398
NZ_CP017717.1\|WP_155128619.1\|9059889_9062739_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP017717.1\|WP_080043210.1\|9054259_9055606_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP017717.1\|WP_080043204.1\|9049607_9050516_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP017717.1\|WP_080043220.1\|9067956_9068358_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043207.1\|9052281_9052998_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP017717.1\|WP_080043208.1\|9053001_9053577_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043206.1\|9051365_9052280_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP017717.1\|WP_080043216.1\|9062869_9063727_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP017717.1\|WP_080043217.1\|9063832_9064381_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP017717.1\|WP_012887858.1\|9067458_9067680_-\|translation-initiation-factor-IF-1	unknown	unknown	gnl\|CDD\|178954
NZ_CP017717.1\|WP_080043219.1\|9066725_9067106_-\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|235358
NZ_CP017717.1\|WP_080043205.1\|9050508_9051369_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|372253
NZ_CP017717.1\|WP_080043212.1\|9056158_9056602_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP017717.1\|WP_080043218.1\|9065627_9066254_-\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NZ_CP017717.1\|WP_003956441.1\|9067320_9067434_-\|50S-ribosomal-protein-L36	unknown	unknown	gnl\|CDD\|179039
NZ_CP017717.1\|WP_043623495.1\|9064504_9065521_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP017717.1\|WP_020542285.1\|9066277_9066682_-\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP017717.1\|WP_155128613.1\|9053587_9054214_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226657

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080043211.1\|9055607_9056132_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.15493e-76
NZ_CP017717.1\|WP_155128615.1\|9056987_9057671_+\|hypothetical-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	3.1729e-45
NZ_CP017717.1\|WP_155128619.1\|9059889_9062739_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.28683e-13
NZ_CP017717.1\|WP_080043210.1\|9054259_9055606_-\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP017717.1\|WP_080043204.1\|9049607_9050516_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.84824e-84
NZ_CP017717.1\|WP_080043207.1\|9052281_9052998_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	0.000362168
NZ_CP017717.1\|WP_080043206.1\|9051365_9052280_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.42052e-78
NZ_CP017717.1\|WP_080043216.1\|9062869_9063727_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	6.80403e-106
NZ_CP017717.1\|WP_080043217.1\|9063832_9064381_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	8.13269e-60
NZ_CP017717.1\|WP_012887858.1\|9067458_9067680_-\|translation-initiation-factor-IF-1	gnl\|CDD\|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	5.2318e-47
NZ_CP017717.1\|WP_080043219.1\|9066725_9067106_-\|30S-ribosomal-protein-S13	gnl\|CDD\|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	2.59555e-76
NZ_CP017717.1\|WP_080043205.1\|9050508_9051369_+\|ABC-transporter-permease	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	0.000242601
NZ_CP017717.1\|WP_080043212.1\|9056158_9056602_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	2.72424e-103
NZ_CP017717.1\|WP_080043218.1\|9065627_9066254_-\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	3.69642e-115
NZ_CP017717.1\|WP_003956441.1\|9067320_9067434_-\|50S-ribosomal-protein-L36	gnl\|CDD\|179039	PRK00465, rpmJ, 50S ribosomal protein L36; Reviewed.	3.28149e-12
NZ_CP017717.1\|WP_043623495.1\|9064504_9065521_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	0
NZ_CP017717.1\|WP_020542285.1\|9066277_9066682_-\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	3.44458e-89
NZ_CP017717.1\|WP_155128613.1\|9053587_9054214_+\|hypothetical-protein	gnl\|CDD\|226657	COG4194, COG4194, Predicted membrane protein [General function prediction only].	1.27029e-18

>NZ_CP017717.1|WP_155128615.1|9056987_9057671_+|hypothetical-protein
MAVLLTGVLIGRLTDGPEPTPHVYLNETAPPAAATANPAPTTARKAQPQAERIPRGITTKKTPRGTATPKPARTPKDQIDGFNTHDDPAVVAEPHDDGVRVMTGMASQVVTLTNAARARRGCGPLRVDSALMRSARTHSLEMARTGRLSHNSPDGASPWDRMERAGYRWGAAENIGAGYGTAQEAVDGWLDSPDHRRNILDCGLKAIGVGVASGPGGPWWTQDFGTQ
>NZ_CP017717.1|WP_080043212.1|9056158_9056602_-|50S-ribosomal-protein-L13
MRTYSPKPADVQRQWYVIDATDVVLGRLASHVATLLRGKHKPIFANHVDTGDFVIVINADKIALSGNKREQKKAYRHSGYPGGLRSVSYGELMEKRPEKAVEKAVKGMLPKNSLGRKMAKKLKVYAGSEHPHQAQQPVPFQITQIAQ
>NZ_CP017717.1|WP_080043211.1|9055607_9056132_-|30S-ribosomal-protein-S9
MAEPTGVETAVETAELEDYSGEDFPSEYTTESAASADAPVRKPVTTGNSYGTGRRKEAIARVRIVPGTGKWTINGRSLDVYFPNKVHQQIVNEPFVVLGAEEAFDVIARIDGGGVTGQAGALRMGLSRALAILDVEVNRPPLKKAGFLTRDARATERKKYGLKKARKAPQYSKR
>NZ_CP017717.1|WP_080043210.1|9054259_9055606_-|phosphoglucosamine-mutase
MARLFGTDGVRGVAGRDLTAELAMDLSVAAAHVLGDAGAFAATGRRPVAVVGRDPRASGEFLEAAVVAGLAASGVDVLRLGVLPTPAVAHLTAALGADLGVMLSASHNPAPDNGIKFLARGGFKLSDAVEDEIERRLGEEWSFPVGSGVGRVRDAYGEADRYISHVLATMTGSLDGLNIVVDCAHGAAHMVAPEALVRAGARVEAIGARPDGLNINAGHGSTHLDKLQQVVISRGADLGVAYDGDADRCLAVDHTGAIIDGDHIMAILAAAMHGEGTLAKDTVVATVMSNLGFKLAMRDAGITVVETAVGDRYVLERMKSDGYNLGGEQSGHVIMLDHATTGDGLLTSLHLLGVVAKSGVPLKELAAVMTPLPQILINVKDVDKGKASVPELVAAVAEAEAELGETGRVLIRPSGTEPMIRVMVEAASEEHATQVAGRLADVVRTACV
>NZ_CP017717.1|WP_155128613.1|9053587_9054214_+|hypothetical-protein
MHGLGADPARRAPTSVFTAFEPVLLQAVVTVAFPALTLVLLRARPDLDAARPAGSARRYRVYLRGMARLSLLGAACVNFSLFIAALRLWEVFALGTAAAVLPLAALVLGPLAWEWRAGQGGHRLPRLPGEEKEDSGLVQRDDDRHWHLAGTVYANRHDPGVVLHARFGQSWTLNLGHPVAWAVVAGLAALVLLALTGIIDLPERHGLF
>NZ_CP017717.1|WP_080043208.1|9053001_9053577_-|hypothetical-protein
MAGRVGAEHRHQTITTTALFVPGRWQALLAKLAVHAVAGLGYGLLSAAMAGAALFAAATAKGITLGLPAGAVLVLLVRIVLAMAAYMLLGVAVGALLPNQVAAPAVLGGYFYLVETALLMVPGANVLYPYLPGGAAAALTGFTYLADAVATQTGGAAVVLLPAWLGAAVLLAYALLAALVAIAAPLRRDIT
>NZ_CP017717.1|WP_080043207.1|9052281_9052998_+|ABC-transporter-permease-subunit
MNTVVAGITYRALLGRRRIILLLLLPLALIALAVLLRAFGAADQATTVDLMQKFAISTMLPLLGLIAGTGVIAPEIDDGTIIHLMSKPISRPVIAQTKFLVAASLLAVFGAVPTYVAGLLLIGGEDGIATGFAAGTLVAGIAYAAVFLLLGIVTRHAVTIGIIYALVWESLVGNLIPGVHKFSIQYWGQSIADQLSDSPFFKTDVALSFAIPALIVVTVGAVLLAGQRLRAFSLTGDE
>NZ_CP017717.1|WP_080043206.1|9051365_9052280_+|ABC-transporter-ATP-binding-protein
MRIELSQVSRWYGNVVAVNDVTMTIGPGVTGLLGPNGAGKSTLLHMMAGFLSPSGGTVTLDGTPVWKNHHIYRNIGLVPEKEGVYGFLTGWQFVLSAARLHNLPDPVEAARKALATVEMEEPKDRRVETYSKGMRQRVKVAAALVHDPPVLLLDEPFNGMDPRQRLHLMDLIRTMGTAGKTILFSSHILEEVERVAQHIEVLVAGRHAASGNFREIRRLMTDRPHLFVIRSSDDRKLAAALVRDDSTGGISLRPDGLEVQATEFRRFARLLPQVARDEGVRLHEVSPADEDLESVFSYLINRST
>NZ_CP017717.1|WP_080043205.1|9050508_9051369_+|ABC-transporter-permease
MSEIYDIGYRHYDGPRLGRAYATRALAVHSLRGVFGIGRPARSKIVPFALAAIMIMPSIVGIAMMALVKQRGIPYSGFAVVMQAVVAIFLAAQAPTVVAPDLRYRVLPLYLSRPVSITEYVGAKVAAMTVAVFALIAVPLTVTYLGELIVDMPGPPATGEYLGAVLMAFLLALLLAAFGLALASFTPRRGLGVASVITVYLLSSASVPIIYGTLYSSGNESAAAWAWLANPFWLVDSVQHWLFGTTPHSIEGAAYPSGPASAAVLVLLIAAGLAALALRYRKAAAR
>NZ_CP017717.1|WP_080043204.1|9049607_9050516_+|ABC-transporter-ATP-binding-protein
MHILATEGLTKRFPTVTAVDQLTVTVGSGVTGLVGANGAGKSTLIKILLGLLPPSGGTARVLDLDVTAQGAQIRRLVGYMPEHECLPPDVSATELVVHLARMSGLPRTAARERAADVLRHVGLAEERYRPVGGYSTGMKQRVKLAQALVHDPKLIFLDEPTNGLDPRGRDEMLTLIRRIGTEFGISVLVTSHLLGELERICDHVVVIDAGRLLRSSAIGEFTQATQTVTVEVDEGLDELAARLTAGGQTVSRQGRLLVVKVLGPATYDAIRDTTAELGLCLIRLEQGRHRIEDVFREEVAHV
>NZ_CP017717.1|WP_155128619.1|9059889_9062739_+|hypothetical-protein
MRGQEPGSEHDRREADRSAVPATPPPSFGQTNGRDVPAAFHPFDEAADADARPVPPVLKAPPSDQETSPGAQPWEVPGDDASPYDWFSDPTTPPPNQHAFDGRQPGWEPPADQHAFGPSSAGAAPFGAPSPDQRAFEPPQSGPAPLGPPPAGPAPSGPPSANQHASGQHAFEQRQPGREAAATHPPFGAQADHSARPNQEPPAGQPFAAPVGHDAHTSQPFAAPTGQEPPTGQEPPVGQPFAAPVGHEPPAGQPFTPPTGQEPHAGQPFAAPVGPSSAPPSGQEPPTGQEAPAGNAFAPPAYQQPFGGPPTGFAPFGAPEGGQPWEAEDGQTRPGRIRDIRPWDQPEGAAGQGAGRWPGEPVVPGAPPWEPPPAFTAAAAGMPAWPAPLSDPHAMPPWPAATGELEAEPDEPSLPPPFDPNATNPEGFTRPPHQATTDANRAAADRPEPPFAQDGLPAPSEQDATNPSGPRPTHQPSPQAAHQPTPQTAPQHGPDTAALREGPDDAAHQGPDHAAHHGPADAITGQGAQDAETPPDGIPQAPDAPAKGGHDQHQPAPSHPDQDQDRPARPHATPDQQEELQPEDTRLSLPFPIAHPSAEAEGQANPSQGPSQGPSQGPSQGPSQGPAHYFDPNATDPTASSSLRPPEPGDVPVWPPTPPAGDKLPELPFSRDSWGQRPSTSLDVPRPPAGGPAFPPGAFKQPPFQTPPPPPPPPKSKRALLVTLGALALAGVATGGFFAFQAVSSAPPTTAATRASAPPSTSAPSSPPDVAGSSILNSEQTDPQKLSLSEAFPKKKVDAAGTTFTRVKADMETTCEKAATGAFADALKAQKCTRVLRATYVDSKRRYAVTTGIAVLPDKDAATTTDQAKDLSRNIWFRPLPGPKNSGGERVHIAGGYAAGLVWGRYIVFSYATHADGHTPEAKDKTLPKVSGAFRDQTALVLERRITKG
>NZ_CP017717.1|WP_080043216.1|9062869_9063727_-|tRNA-pseudouridine(38-40)-synthase-TruA
MVRLRLDLAYDGTDFSGWARQPGLRTVQGEIEQALGRILRLDGPAMLTVAGRTDAGVHARGQVAHVDVPEAALGELDGNRGPLGVDERLSALVRRLGGVLEPDVRIYRVSVAPEGFDARFSAMFRRYAYRVSDAAGGVDPLRRREVVWHNRPLDLDAMNAAAARLVGEHDFAAFCKKREGATTIRELQRLEWERRADGVLEATVVADAFCHSMVRALVGSLLAAGDGRRPVEWPGQVLARAVRDSGVHVAPAHGLCLEEVGYPPEAELAARAQATRRVRTASTQL
>NZ_CP017717.1|WP_080043217.1|9063832_9064381_-|50S-ribosomal-protein-L17
MPKPTKGARLGGSPAHERLILANLATDLFRHGKIRTTVAKAKRLRPLAERLITKAKKGDIHNRRQVLTVVRDKGVVHHLFTELATTFAERPGGYTRITKIGPRKGDNAPMAVIELVTEPLNGVTTRRTEAPAAAAAPAAEETKAEETEAPEAAEATEAKAEAADEAPAAEAAEAGEAKKDEA
>NZ_CP017717.1|WP_043623495.1|9064504_9065521_-|DNA-directed-RNA-polymerase-subunit-alpha
MLIAQRPTLLEESIDETRSRFVIEPLEPGFGYTIGNSLRRTLLSSIPGAAVTSIRIEGVLHEFSTVPGVKEDVTDIILNLKELVVSSEHDEPVVMYLRKQGPGEVTAADIAPPAGVEVHNPELRIATLNGKAKLEMELTVERGRGYVSAAQNKQPGQEIGRIPIDSIYSPVLKVTYKVEATRVEQRTDFDRLILDVETKPAMKPRDAVASAGKTLVELFGLARELNVEAEGIDIGPSPTDAALAADLALPIEELNLTVRSYNCLKREGIHTVGELVARSEQDLLDIRNFGAKSIEEVKQKLHEMSLALKDSPPGFDPSAVAGGGYDDDDSAYVETEQY
>NZ_CP017717.1|WP_080043218.1|9065627_9066254_-|30S-ribosomal-protein-S4
MARYTGADCKLCRREKTKLFLKGSKCESAKCPIEIRPYPPGEHGRGRPKESEYQLQLREKQKTRRIYGVLEKQFHNYYEEAAGRTGKSGEVLLQILESRLDNVVYRAGFAQSRDAARQQVRHGHFLVNGKKVDIPSYRVREHDIIEVRETKRNLMPYEVARATAGERTVPAWLGVVPDKLRVLVHQLPVRQQIDTQVQEQLIVEYYSK
>NZ_CP017717.1|WP_020542285.1|9066277_9066682_-|30S-ribosomal-protein-S11
MPPKSRQGAPKKVRRKEKKNVAHGHAHIKSTFNNTIVSITDPNGNVISWASAGHVGFKGSRKSTPFAAQMAAENAARRAMEHGMRKVDVFVKGPGSGRETAIRSLQATGLEVGSIQDVTPVPHNGCRPPKRRRV
>NZ_CP017717.1|WP_080043219.1|9066725_9067106_-|30S-ribosomal-protein-S13
MARLVGVDLPREKRLEIALTYIYGIGRTRAKEILEATGVSGDLRVHQLSDTELVPMRDYIEANFKIEGDLRREVQADIRRKIEIGCYQGIRHRKGLPVHGQRTQTNARTRKGKKKTVAGKKKPGKK
>NZ_CP017717.1|WP_003956441.1|9067320_9067434_-|50S-ribosomal-protein-L36
MKVKPSVKKICDKCKVIRRHGRVMVICDNLRHKQRQG
>NZ_CP017717.1|WP_012887858.1|9067458_9067680_-|translation-initiation-factor-IF-1
MAKKDGAIEIEGTVVESLPNAMFRVQLDNGHKVLAHISGRMRMHYIRILPDDRVVVELSPYDLSRGRIVYRYK
>NZ_CP017717.1|WP_080043220.1|9067956_9068358_-|hypothetical-protein
MRKVLAATALAGSMAVAALAVSPAAQAATTATVSASSSGWGKYYSSNNKAYTYGKTYKSGGKVYTHWYGKESSPKHGYVWFKYYSGGKWHQFYRHWNGSYDATWSGRGIKKIDTWTCWGGKHKYCGSHHRIYG

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Crispr_ID: NZ_CP017717_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_25

9362629-9362740

Orphan

Consensus_repeat	Method
CGAGCAGGCTCATGCGGCCCTCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP017717_25

>merge|NZ_CP017717|25|9362629-9362740|CRISPRCasFinder
CGAGCAGGCTCATGCGGCCCTCCTCAGCCGGGGGTCGGACGCGGCCTTTCCGAGCAGGCTCATGCGGCCCTCCAAAAGCACGACCTCTCCGAGCAGGCTCATGCGGCCCTCC

>NZ_CP017717|25|22|9362629-9362740|CRISPRCasFinder
CGAGCAGGCTCATGCGGCCCTCC	TCAGCCGGGGGTCGGACGCGGCCTTTC
CGAGCAGGCTCATGCGGCCCTCC	AAAAGCACGACCTCTC
CGAGCAGGCTCATGCGGCCCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043460.1\|9351719_9352454_+\|nucleotidyltransferase	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047313.1\|9349944_9350883_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|223538
NZ_CP017717.1\|WP_080043463.1\|9353986_9355162_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180297
NZ_CP017717.1\|WP_080043464.1\|9355518_9356718_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080043477.1\|9369674_9371204_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273331
NZ_CP017717.1\|WP_155128660.1\|9358177_9360238_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP017717.1\|WP_080043472.1\|9366632_9366992_+\|DUF2809-domain-containing-protein	unknown	unknown	gnl\|CDD\|378530
NZ_CP017717.1\|WP_080043462.1\|9353329_9353926_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP017717.1\|WP_080043473.1\|9366947_9367781_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319
NZ_CP017717.1\|WP_080043471.1\|9364673_9366488_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NZ_CP017717.1\|WP_080043476.1\|9368981_9369524_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153228
NZ_CP017717.1\|WP_080043461.1\|9352583_9353222_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371689
NZ_CP017717.1\|WP_080043470.1\|9363604_9364657_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP017717.1\|WP_080043478.1\|9371246_9372719_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP017717.1\|WP_080043467.1\|9360501_9361509_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP017717.1\|WP_080043479.1\|9372876_9373512_-\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|319743
NZ_CP017717.1\|WP_080043474.1\|9367882_9368590_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187585
NZ_CP017717.1\|WP_080043459.1\|9350893_9351709_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187620
NZ_CP017717.1\|WP_080043465.1\|9356842_9357490_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_080043475.1\|9368591_9368858_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080047313.1\|9349944_9350883_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|223538	COG0462, PrsA, Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism].	8.49929e-119
NZ_CP017717.1\|WP_080043463.1\|9353986_9355162_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|180297	PRK05868, PRK05868, FAD-binding protein.	2.93509e-113
NZ_CP017717.1\|WP_080043464.1\|9355518_9356718_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.99454e-34
NZ_CP017717.1\|WP_080043477.1\|9369674_9371204_+\|amino-acid-permease	gnl\|CDD\|273331	TIGR00907, Choline_transport_protein, amino acid permease (GABA permease). [Transport and binding proteins, Amino acids, peptides and amines].	1.2754e-84
NZ_CP017717.1\|WP_155128660.1\|9358177_9360238_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	6.79707e-11
NZ_CP017717.1\|WP_080043472.1\|9366632_9366992_+\|DUF2809-domain-containing-protein	gnl\|CDD\|378530	pfam10990, DUF2809, Protein of unknown function (DUF2809). Some members in this family of proteins are annotated as yjgA however currently no function for the protein is known.	1.9867e-17
NZ_CP017717.1\|WP_080043462.1\|9353329_9353926_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.39144e-13
NZ_CP017717.1\|WP_080043473.1\|9366947_9367781_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.41263e-47
NZ_CP017717.1\|WP_080043471.1\|9364673_9366488_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.28354e-113
NZ_CP017717.1\|WP_080043476.1\|9368981_9369524_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153228	cd03134, GATase1_PfpI_like, A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. This group includes proteins similar to PfpI from P. furiosus. and PH1704 from Pyrococcus horikoshii. These enzymes are ATP-independent intracellular proteases and may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For PH1704, it is believed that this Cys together with a different His in one monomer and Glu (from an adjacent monomer) forms a different catalytic triad from the typical GATase1domain. PfpI is homooligomeric. Protease activity is only found for oligomeric forms of PH1704.	2.25795e-78
NZ_CP017717.1\|WP_080043461.1\|9352583_9353222_+\|hypothetical-protein	gnl\|CDD\|371689	pfam11716, MDMPI_N, Mycothiol maleylpyruvate isomerase N-terminal domain.	0.00366197
NZ_CP017717.1\|WP_080043470.1\|9363604_9364657_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.13477e-109
NZ_CP017717.1\|WP_080043478.1\|9371246_9372719_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	4.27659e-13
NZ_CP017717.1\|WP_080043467.1\|9360501_9361509_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.5941e-116
NZ_CP017717.1\|WP_080043479.1\|9372876_9373512_-\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|319743	cd16444, LipB, lipoyl/octanoyl transferase. Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.	3.97585e-76
NZ_CP017717.1\|WP_080043474.1\|9367882_9368590_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.68699e-76
NZ_CP017717.1\|WP_080043459.1\|9350893_9351709_-\|SDR-family-oxidoreductase	gnl\|CDD\|187620	cd05362, THN_reductase-like_SDR_c, tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs. 1,3,6,8-tetrahydroxynaphthalene reductase (4HNR) of Magnaporthe grisea and the related 1,3,8-trihydroxynaphthalene reductase (3HNR) are typical members of the SDR family containing the canonical glycine rich NAD(P)-binding site and active site tetrad, and function in fungal melanin biosynthesis. This subgroup also includes an SDR from Norway spruce that may function to protect against both biotic and abitoic stress. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.00487e-51
NZ_CP017717.1\|WP_080043465.1\|9356842_9357490_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.25941e-67
NZ_CP017717.1\|WP_080043475.1\|9368591_9368858_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	1.76569e-14

>NZ_CP017717.1|WP_080043467.1|9360501_9361509_-|ABC-transporter-ATP-binding-protein
MTETQTTAEAVTTTRPTLLEARDLHVEFSSRGRRARAVDGVNLAIGEGEIVALVGESGCGKTTLARTLLGLERPTSGEVRYDGNPLTYTSKALKTYRRQVQLVLQDPTGSLNPRHTVYEAVAEGPRIHGLPDEQDLVSKALSHAGLRPPDRFFLRYPHELSGGQRQRVVIAGALALNPKVLIADEPVASLDASVRGEILALLLRLRDELGLSALVVTHDLGLAWNIADRVAVMYLGRIVESGPVEQVLTAPRHPYTQALMSVLPESPERVVLTGEPPDPTRIPGGCRFHARCQVLASGKAAEAGVHTRCRTEPLPILPATPEAQAACYYAETTTP
>NZ_CP017717.1|WP_155128660.1|9358177_9360238_-|alpha/beta-fold-hydrolase
MPAFLAISPPFPWPPLRTRLCRPGAAPASRHHARLRPATCAPAPVPAPAPCRPLRPCRPLRPCRPCPHSRPCAPACAPGGRTESRHRARPWPAPCALPPRSCLGLVGNGAETAAALLLYRMTHRTSRAAPASSPVLSLSPALALSLALSLALAVLVAHPSTASATAVPLTGSTATVPAPVGTITASAVVSTAATSTALGAGSGVSSVEWAACPSYTDDVIRSLGVKEEQIPAFRTEMKRLQCGKVSVPLDHRDPTGRTIDIAVTRLAATNQQERLGAVAVLPGGPGNSGYLDPILRAALRNEEMARLNERYDIIGFDPRGVGYSTKVACPTPPVGPQAPGAFTKETARKVYDAQLAANQQCGRSDPAFLGQLTTTNVAKDLNLVRTALGESKLNLLGFSWGTYLGMVYRSQFPQHTGRAFLDSVAPPWTDLVRHTEGAAEAAERDFGRMAAWLARRDGLYGLGATAAQVRREVAKLVRTYDKSPKTYTDLQRPIDGSAVADLAKLNSTDWARAGKALSELRTSTGTTAPPTVKQLLGAPMMGTPAPGAPEMLNRTMNWAVACNEDDSRPSFDTAWRTYQRLVERLPATGRGWGLGGAMCQGWPLPVQQAELRRGSGSLVLGGHLYEFMSAYDWTLQTRRAIGGTVYTVADDVHVSTTRVPECAADVVRYFETGRIDRGCPGTPLPS
>NZ_CP017717.1|WP_080043465.1|9356842_9357490_+|response-regulator-transcription-factor
MIRVLVVDDEALVRSGLRMILEAAGDISVIGEARDGAEAVSAVGRLRPEVVLMDVRMPGMDGLTAAARILKAPEAPKVVMLTTFDADEYVHEALRLGAVGFLLKDTPPRELASAVRTVAGGQAMLSPSVTKRVIEQYADRAPSRAEAARRQLEGLTDREEDVIKALARGLSNAEIGRELRLTEATVKAHVSRVLAKLGLANRVQAAILVHDADLT
>NZ_CP017717.1|WP_080043464.1|9355518_9356718_+|histidine-kinase
MRFALLGVAVLAVSLFVMSGQMGVPSDLPFPVQVAIAGAAGVAAWHARRSWWPLAALGAVTYAWLVVWPPLLVASYFAGRTLGRGRGLAAYLGACLAVQGVSALVGEARDGPQEIMTASLGNALFMALGTIGLPLAVGLWTRARKETAEERARRLEREQIMRAEQVRAQERARIAREMHDIVAHRVSLIVLHAGALEVRTTDEETAETAALIGGIGREALSNLRDVLGVLRTPRPDSPAPDLSPHPALDDPDLSPRPALGDPDATYRPQPTLGDLDRLLDQSRALGITVTRHDEGDPRPVEETVERTAYRVIQEALTNVHKHAGDAHTDVLLRFADGELEVEIRNQRPHGHPENLLGTDLSGAGWGLVGLRERVELLGGTLRTSTEESGGFLVSARIPA
>NZ_CP017717.1|WP_080043463.1|9353986_9355162_+|FAD-dependent-oxidoreductase
MTNILISGASIAGTATAYWLRRHGYAVTVVERAPAIRTGGYKVDLRGAALQVIERMGLLDAVRARATDMRVATYYDASGRPLTTVDADLFGGRTGPDAEIMRGDLNELLYDLTRDDVEYIFDDSITGIAEDGTVTFERSRPRAFDLIVGADGAHSNVRRLTFGDESAFTRDLGHYISICTVPNTLGLDREEAVHATAGRTANVYSTRQDTRAKALFMWSSPPLTYDHRDVAAQKNLLAQAMDGVGWQVPALLDAARDADDFYFDSVAQIHLDRWSKGRVVLVGDAGYCASPASGQGTSLAVVGAYVLAGELATGGGTDGYERELRPFVTANQALGPANIKGMVIGSRAALWFQLTMMRLLPHLPGRNRMIERITGPIARAANAITLKTYDH
>NZ_CP017717.1|WP_080043462.1|9353329_9353926_-|TetR/AcrR-family-transcriptional-regulator
MGNREDLLAGAKQCLIEKGYSRTTARDIANASGVSLAGIGYHFKSKEALMNEALFEVMQEWGEELEATLAADVRADATPLERFEAAWDRVVESFEKLRPLWVTQFELLGQIDHVPEVREQLVRAIGEARLGLAELFEGVAQGTDPERERLTGTVYQAMLTGFLSQWLLDPDSALSGREVVAALRMIVNGSGSDDTSIP
>NZ_CP017717.1|WP_080043461.1|9352583_9353222_+|hypothetical-protein
MGESRQSYLVAAASAVSLLRDPAVAASWDKPSALMEFSVAGLAGHLAHQLVRVGDVLPPNGQAGEPITLIEHYSRSPWVQAGLDHESNLSVRRGGEAAAAAGPAVLVERAQALYEMQSAALAAEPADRVVFLPWSGWSLRLDDFLLTRLVELVVHSDDLAASVGVETPELPASVIDPVVELLARLAVHRHGPTAVIRTLSRAERAPATISAF
>NZ_CP017717.1|WP_080043460.1|9351719_9352454_+|nucleotidyltransferase
MHAATERLLTHFLESIEPAVPLVALWAHGSLAAGDYQEGRSDLDLIAVLDSPATMGDWRRIKAVHRRIRLPLAELLHCSYMSRQELDDLGAEHITWAHQQIYRRPVSAVTRRELHDGARVLYGPPPAGLLPPVSDEELIRYVRTDLRDFWLVKAQERRRWLQDVWVDLGMLTVARATVTLREGRLISKLEALDVLAGMGAPEPVVADVRARRYGTPRPVLSRFRRGRLARAFVRSAIRQALATA
>NZ_CP017717.1|WP_080043459.1|9350893_9351709_-|SDR-family-oxidoreductase
MIDTGLSGKVALITGANHGIGAATASALAAEGVAVLLTYKRLEPLNEPAYPDTYDRARAGTADEVVRRIREAGGTAEAFEADLADAEAPKRLFDLAEETFGPVEILVNNASGWLSDTFTPTERDGFGRPLRLVDAETHDRQFAVDARAAALLIAEFARRHLARGASWGRIIGLTSGGRDGFPTEVSYGAAKAAQENYTMSAAHELGRYGITANMVYPPVTDTGWINDEVARAVAESAVLKEIAQPEDVAEVITFLASHQGRRVTGQTIRMY
>NZ_CP017717.1|WP_080047313.1|9349944_9350883_+|ribose-phosphate-pyrophosphokinase
MRDITVFSGSAHPELAEEICAHLGTPLHPVQINRFANDVLEVQLQANCRERDVYLIQPLVPPVQEHLVELLLMLDAARGASAARTTVVMPHYAYARSDKKDAPRISIGARLVADLMVAAGASRVLAMTLHSPQVHGFFSVPVDHLHALRELAAHFRRYDLSNTVVVSPDLGNAKEAAHFARLLGTGVAMGAKQRFSDDRVVISSVIGDVAGKDVIILDDEIAKGSTVIELLDRLRERDVRSVRVACTHGLFSADALDRLSALPEVQEIVCTNTVPPPKPTDKLTVLSIASALAEAMRRIHYGESVSALFSTS
>NZ_CP017717.1|WP_080043470.1|9363604_9364657_-|ABC-transporter-permease
MTTPLESAEPAVQAAGPADERPTSRGTLQYALSKAGGALFSIAMVLVGTFFVFRLLPGDPVRNLAQGRNMTPDQLDLERRRLGLDKPLIDQFLNFVGDTLRLDLGTSYEYKRPVIDLIGERIGPTLLLTGTGLVIAVSLGIWQGTRAGWRHGSRFDRVSTGVSLLLWSVPTFWLGLLLMMVFGVGIGPIPSLFPFRGIESVDAPDGFGYVLDVASHMVLPCLTLVAVVYAQYLMVMRSSLLEEVSQDYVTVARAKGLRDDEVRRRHAVPNALLPTVTLVFMRIGFVVGGAVTVEYIYTWPGLGQLFYRAIEVPDFTLMQGTFMLITVSVIVMNTLADVVYHLLDPRVRSA
>NZ_CP017717.1|WP_080043471.1|9364673_9366488_-|ABC-transporter-substrate-binding-protein
MRKWFARLAVLGAALLVAGQGATAAHAQDPAAGKKIVRVGATQAMDSMNPFLAVRLVSTSIHRWMYGFLTVPDSKTLQPSPDLAESWTTSEDGLTWTFKIRQAKWSDGQPITADDAAWTFNKMMTDEAAKTANGPAVENFESVTASGQDLTIKLKAPQASMLDNPVPIMPKHVWESVTDMANYDAEKYPAVTSGPYIAIEHKKDNYVKLQANPNYWRGKPKIDELQVIFYDNPQAAIAGLKNGDIDLLGRMTPQEFEGIQNNPNIEAWNTQGRRASYLQINHGATTSDDKPIGDGHPALKDVKVRQALHYAIDKQKLVDEVQNGLAKVADGSIVPPMYKDFFWEATGDTKVTYDPAKANKILDDAGYKKGADGIRTMPDGKRKLEWRFTIHTDTPIEDKLAEYMTGFLKEIGVTLTTVKLDSSKFTEETGITGNFDIAISGWSVNPDPEEVFATHLCSRRPDANGEGGGTESFYCNKTFEQLYKDQQKELDRTKRAEIIKKMQEQLYTDAPIIAIYYTNDLEGYRKDRITSITPIPEDKGLLYGGSGYWPFYTVDVKAQAAGGGSAGGGSNTGLIAGIVGGVIVVGAAAFLLTRRRKSTADERE
>NZ_CP017717.1|WP_080043472.1|9366632_9366992_+|DUF2809-domain-containing-protein
MVPRPLIAVTCVVIVACGLGVRALWDGPVPKYAGDALYTALIYALVVLILPRVRPWVAAAVSAGLSWAIEFAQLAEIPEVLRPVLGSTFNPPDLLWYAVGAALCWLAHHRLRAEDTEQG
>NZ_CP017717.1|WP_080043473.1|9366947_9367781_-|helix-turn-helix-transcriptional-regulator
MREFGQAVRRWRERVAPETVGLAAGGRRRAAGLRREELALLAGISVDYVTRLEQGRAANPSPQVVEALARALRLSADERSYLFRTAGLAPPCPDTVPAFIPPSVHRMLDRLAGTPVGVYDAAWTLLLANPMYAALMGDPSGWRGNERNGVWRNFVGPGSRVRYTPEERRTFEAMMVADLRATAAQYPADQQLRRLVAELRAGSARFAELWDSGVVGRQEGGPKTIEHPQVGPLTLDCDILSVAGSNLRIMVYTAEPGTPDAERLALLGVLGTQSMVG
>NZ_CP017717.1|WP_080043474.1|9367882_9368590_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTTTLITGANKGLGHETARRLIEAGHTVYLGSRDAERGRAAADRLGARLVVLDVTDDDSVAAAVKTIEADGGLDVLVNNAGIEGRTADGGVIGAADVTADDLRTIFETNVFGLVRVTHAFLPLLLRSPAPVVVNVSSGLASLARMTTEGTPAYAYPGVAYPASKAAVNMITVQYAKAFPQLRVNAVEPGFTKTDLNHNTGIQTVEEGAEIIVRMAQVAPDGPTGGYFDAKGPLPW
>NZ_CP017717.1|WP_080043475.1|9368591_9368858_-|heavy-metal-associated-domain-containing-protein
MTVATYQVEGMTCGHCVSAVTQEVGKVAGVSGVEVDLASGAVTVTSAAPVDAALIDAAVVEAGYELRGKVDLLPQVSGSSCCGSGGCH
>NZ_CP017717.1|WP_080043476.1|9368981_9369524_+|type-1-glutamine-amidotransferase
MLDGKTIAFLVAPEGVEQVELTEPWKAVKQAGGTPKLVSTSSGQVQGFNHLDKADTFAVDNTVDSAEAASFDGLVLPGGVANPDFLRTVPEAVRFVRAFFDAGKPVAAICHAPWTLIEADVVRGRTLTSWPSLQTDLRNAGATWVDKEVMVCTQGPNTLVTSRKPDDLKAFCQAATDAFS
>NZ_CP017717.1|WP_080043477.1|9369674_9371204_+|amino-acid-permease
MTTEEDSRRLAELGYKQELARTWSGFSNFAISFSIISILAGCFTTFGQAWNNGGPIAISWGWPLISVFILIIGFCMSELVSAYPTAGGIYWWAAKLGKPIHGWFTGWLNLIGLVAVTASVDYGCATFLNITLNRLTGGAWEGTLPQAFLLFVIVLALHALINIYSHKLISLLQNVSVWWHVAGAAIVVAILIFAPENHQSASFVFFGTNNSSGFGDGSDGLPFWLYVLPLGFLLTQYTITGFDACAHVSEETQGAARSAARGLWQSIFYSAIGGWILLLSFLFAATHVDEINKNAGFVGTIFDTALSSPLATAIFAISTIGQFFCGMSCVTSMSRMTYAFSRDGAVPGWRLWSKVDRNRTPVNAIIAGCVAAALITLPALYAPAGLTTPVAFYAVVSIAVIGLYLAFLIPIWLRLRMGDAFQPGPWTLGRKYKALCWIACVEIVIVSIYFIMPFSPAGVPGSADFTWTSVNYAPIAVGVVLIGIALWWALSARHWFTGPRRTIDEVPAA
>NZ_CP017717.1|WP_080043478.1|9371246_9372719_-|alpha/beta-fold-hydrolase
MAMATLASVSPANAETEARTITWAPCEEEPAAECGKLTVPIDWSKPDGPTVDIAVARRKATDPAARIGSLVINPGGPGGSGVEAAFGATWFTDELQKRFDIVGFDPRGVGRSHPVICSASVYNQMPHTVMKSQADFDAWNAFTKKLHADCRERTGPLYDHVDSQDVARDMDALRAALGEEKLTYYGISYGTLIGQMYAELFPDRVRALGLDSNMDHSLNVAGFLSTEALAVEDGFDQFVGWCDQDPSCVLHGQDVRAIWKGLLDKARRGELVYPSTGTKMTELQVIYNAALGNEGPDWQTLSQTINWLNGGAEPDWVPPLPGRGPVEGDVAELPTTILCQDYNLRVRNYAEYATLMKVSNTLAPDTRYHPYPIDDLPICMNYPTTNPPHQLKYTGDAPLLLGNSLHDPATPWIWSANAARQLGSKAVLLTYEGWGHRIYGKDKCQTDIFDEYLISLKVPAHGTRCAVGTPEETLKLRSTKPAWPTDRLSW
>NZ_CP017717.1|WP_080043479.1|9372876_9373512_-|lipoyl(octanoyl)-transferase-LipB
MRARPLTLIQDELVDYDQAMERMTDLVGQRQSDERPDTLWLLSHPSVYTIGRRTPVSHLPDPTHGIPVVETGRGGQLTYHGPGQLVGYLIVKLDEGEGIVDYVREVELRLVEALGKLGLPAERRDTPPGSELLTGVWTTETGRKIISIGMRQSRGVTSHGFALNVDGDLTPWSWAVACGMPDVDMTSLKRELGSASMDEVRAAVAEAFEAS

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Crispr_ID: NZ_CP017717_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_26

9485942-9486092

Orphan

Consensus_repeat	Method
CCGGAGGAAGGCGGGGCAGAGAACGGCGCGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP017717_26

>merge|NZ_CP017717|26|9485942-9486092|CRISPRCasFinder
GCGGGCCGAGGCGGGCCGGAGGAAGGCGCGCTCGTGGGAAGCGGGGCGGAGGACAGCGCGCCCGTGAGAGGCGGGCCGGAGGAAGGCGGGGCAGAGAACGGCGCGCCCGCGAGAGGGGACCGGAGGAAGGCGGGGCAGAGAACGGCGCGCC

>NZ_CP017717|26|23|9485942-9486092|CRISPRCasFinder
GCGGGCCGAGGCGGGCCGGAGGAAGGCGCGCT	CGTGGGAAGCGGGGCGGAGGACAGCGCG
CCCGTGAGAGGCGGGCCGGAGGAAGGCGGGGC	AGAGAACGGCGCGCCCGCGAGAGGGGA
CCGGAGGAAGGCGGGGCAGAGAACGGCGCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043575.1\|9486787_9487609_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP017717.1\|WP_080043574.1\|9486392_9486572_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043568.1\|9473198_9473690_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240041
NZ_CP017717.1\|WP_080043572.1\|9482694_9484005_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080043570.1\|9474853_9476395_-\|NADH-quinone-oxidoreductase-subunit-N	unknown	unknown	gnl\|CDD\|235603
NZ_CP017717.1\|WP_080043580.1\|9492058_9492616_-\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NZ_CP017717.1\|WP_080043567.1\|9472382_9472880_+\|YajQ-family-cyclic-di-GMP-binding-protein	unknown	unknown	gnl\|CDD\|377366
NZ_CP017717.1\|WP_080043581.1\|9492679_9493798_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320687
NZ_CP017717.1\|WP_155128696.1\|9494040_9494412_-\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|169084
NZ_CP017717.1\|WP_080047327.1\|9477973_9479842_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NZ_CP017717.1\|WP_080043576.1\|9488469_9489309_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180446
NZ_CP017717.1\|WP_080043571.1\|9481474_9482683_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|235637
NZ_CP017717.1\|WP_155128694.1\|9488029_9488584_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP017717.1\|WP_080043569.1\|9473716_9474568_-\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|235102
NZ_CP017717.1\|WP_080043577.1\|9489432_9490266_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP017717.1\|WP_080043566.1\|9470382_9471843_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP017717.1\|WP_080043579.1\|9491486_9492062_-\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|376317
NZ_CP017717.1\|WP_080047326.1\|9476391_9477951_-\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|273903
NZ_CP017717.1\|WP_155128692.1\|9484415_9485375_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043578.1\|9490552_9491494_-\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|376297

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080043575.1\|9486787_9487609_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	2.82196e-43
NZ_CP017717.1\|WP_155128694.1\|9488029_9488584_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000158763
NZ_CP017717.1\|WP_080043572.1\|9482694_9484005_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.04045e-82
NZ_CP017717.1\|WP_080043570.1\|9474853_9476395_-\|NADH-quinone-oxidoreductase-subunit-N	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	8.67253e-100
NZ_CP017717.1\|WP_080043580.1\|9492058_9492616_-\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	7.12225e-90
NZ_CP017717.1\|WP_080043567.1\|9472382_9472880_+\|YajQ-family-cyclic-di-GMP-binding-protein	gnl\|CDD\|377366	pfam04461, DUF520, Protein of unknown function (DUF520). Family of uncharacterized proteins.	4.21183e-82
NZ_CP017717.1\|WP_080043581.1\|9492679_9493798_-\|M48-family-metalloprotease	gnl\|CDD\|320687	cd07328, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase. This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.	4.56699e-28
NZ_CP017717.1\|WP_155128696.1\|9494040_9494412_-\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|169084	PRK07756, PRK07756, NADH-quinone oxidoreductase subunit A.	2.14883e-37
NZ_CP017717.1\|WP_080047327.1\|9477973_9479842_-\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	8.94647e-169
NZ_CP017717.1\|WP_080043576.1\|9488469_9489309_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180446	PRK06180, PRK06180, short chain dehydrogenase; Provisional.	7.06628e-84
NZ_CP017717.1\|WP_080043571.1\|9481474_9482683_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	7.34205e-40
NZ_CP017717.1\|WP_080043579.1\|9491486_9492062_-\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|376317	pfam00329, Complex1_30kDa, Respiratory-chain NADH dehydrogenase, 30 Kd subunit.	1.25981e-49
NZ_CP017717.1\|WP_080043569.1\|9473716_9474568_-\|zinc-metalloprotease-HtpX	gnl\|CDD\|235102	PRK03072, PRK03072, heat shock protein HtpX; Provisional.	6.01395e-158
NZ_CP017717.1\|WP_080043577.1\|9489432_9490266_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.17294e-55
NZ_CP017717.1\|WP_080043568.1\|9473198_9473690_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	7.54016e-28
NZ_CP017717.1\|WP_080043566.1\|9470382_9471843_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.09927e-13
NZ_CP017717.1\|WP_080047326.1\|9476391_9477951_-\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|273903	TIGR01972, NADH-quinone_oxidoreductase_subunit_M, proton-translocating NADH-quinone oxidoreductase, chain M. This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport].	2.52373e-157
NZ_CP017717.1\|WP_080043578.1\|9490552_9491494_-\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|376297	pfam00146, NADHdh, NADH dehydrogenase.	2.00213e-114

>NZ_CP017717.1|WP_155128692.1|9484415_9485375_-|hypothetical-protein
MNQLRPCAGATKDSRCPQTILTSDDQTLTVTDEITGDSTSLKPASLYHYRYDQQPTSGEKPTTIHGLAALDPDGLVLVDLPGSWHAVDLAEFARKAAIPLEDARNHPANEIRAVLAARAPGWRRVRGLPCPSMAKWRKPVGIGLGIAGGALMVYLASLGMWAAWRGVSTIGRVIVDLLEAKWLVVAFSPALLLFRPALARIHRRRVKRGTIVGPYGGPYLSLHSATKLQITQGNHTVAKLRLGENPGQAFSLLLYRYEDLSGLLILDRFGRRALHHIPGLWPPQDVERFAKRHNLALAVHRVSREEYLALTKHANEATP
>NZ_CP017717.1|WP_080043572.1|9482694_9484005_+|serine/threonine-protein-kinase
MTHLAPEVNERARCPQFFHSCPQVDGRLSTTCVHARYEPRHGDSLSAMQHSHPVRPSGLRWTAAVGWACLPLFTCGLATPVTIGIAAFWLRNIWHGVAAAVYLVGIGSFVIVILAYDTYEDIPASLSMIITVGLFVSWFGGLVHAAVLVPFMARARLTAPSYPQVDLRQRTTAPSHQRRPGDPEWVGHYRVLQQLGRGGQGSVYLAMAPNGARVAVKVLHDLVDEVARARFAREVEAARRVATFSTARVLDVNITGRHAYIVSEYIEGPSLEQLVKKYGPRDQDSLTRLALSTAGALAAIHKAGVVHRDFKPSNVLIGHDGPRVIDFGIARALDQVTVTSGKMVGTPPYMSPEQLTGAAVGPASDVFSWAVTIMFAATGRPAFGEDTVPAVFHRVLTFHPDLSPLPPGLRGIVKACLNKKPEERPSASDVMLAIVR
>NZ_CP017717.1|WP_080043571.1|9481474_9482683_-|4Fe-4S-dicluster-domain-containing-protein
MARIPGVGLAKGLSITLRHMLRKSVTQQYPEVKPDLPPRSRGVIALVEENCTSCMLCARECPDWCIYIDSHKETIPAPEGGRARQRNVLDRFAIDFALCMYCGICIEVCPFDALFWAPEFEYAEGDIRNLLHEKDKLATWVPSVPPPPAHEVGAEPPKELTAAPRRPAADRPARTPAAQRPRTVPEKTTPQETVPQETAPEEQAPSATAEPAPETGPAAPPSRTPGGRPRRPMTNVRGIRPPGALPSTPPSGTPSQQEGAANAEPGSAGEQTRPQNDRPQGDRPQGDRQEGERPGRSQEAARGESQPEGQEAAQGESQREGQKAAQDEPQRQGQEAQDQASSTGQPPEDKLSTAAAESRSKPENEEQTSSASPRRRRMADPRSIRPPGRLGPDEPKESEEES
>NZ_CP017717.1|WP_080047327.1|9477973_9479842_-|NADH-quinone-oxidoreductase-subunit-L
MDLPHDSTATSGRTSLPRNSTPTYGRDKAHTRAAWIAILPTAAAAILTIWLAWKPGLAYFSGTATPPTGQTYGTIVTGGLPISLTLQADALSSVIGVLVTLVALAVQVYSVGYLEDDPRYPSYSAFISLFTSAMLLVVYAGDLLVLYVGWEIMGLCSYLLIGHWWEDRGNSRAAVKAFLVTRLGDVGFLFGIFVLGTAAGSFRVSEVLARVPEMSAATLVTATMLLLAGVAGKSAQVPLHTWLPDAMAGPTPISALIHAATMVAAGIFIVARLFPAFAAARPTLDVLAVIAALGMLGAALAALAQDDLKRVLAYSTVSQLAYMAGGLAAGSDTAAVFHLLTHGAFKALLFLCAGAVIHHVGSNLMTQMGGLRRELPVTFVTMTIGFAALMGIPPASGFFSKDGVLLAMDGALSSGGLTDAAAFFLYGCALATVAVTGAYATRAWLRTFFGEARAVALPEPEPGTAHVVDVREAPRTMLVPVILLAAPALLLGFAGEPHVELGVAAVSVLLAALGAGAVYAFWRLDPVADPARLLGPLRAPCERAFYVDTLYAALFVRPVLALARLVVRTDDVVVDGAVRGSGKSARGLSGMLRLAQNGNVQLYVSGVLAGVLLIAVGAVVFT
>NZ_CP017717.1|WP_080047326.1|9476391_9477951_-|NADH-quinone-oxidoreductase-subunit-M
MGWIPVALLAVPLLGALLLLLAPRTFRGVLPAYGLIFSGVTLALSLALLALYDYGGPARMRFELDLPWIPGLGLRLHLGVDGVSLPLIVLTALLTFLCFVYLCWGRARATGGFMSARPRALVFTLLVLEVGMIGTFLALDLLLFFVFFEIVLIPMYFLIGVWGGEGRRAASIKFILYTLLGSVVMLLGLLLVWAQTGTLDIEALTAAHGAGMPRSVQILAFVAIGIGLAVKTPMWPLHTWLPDAHTEAPTVGSVLLAGVLLKMGTYGFARIAIPVLPEGAAAVAPWLGAFAVVGIVYGALACLAQRDLKRMIAYSSVGHMGFVLLGFATLTPVGVNGALFANVAHGLITGLLFFLAGAVKERYHTSEMPALGGGMLATMPRLGSMLTFASIASLGLPGLAGFWGEMLALFGAFQPANGLPRGLFLTYMVIGGLGAVLTAAYFLVMLSRVTHGRPRDSAERHESPDERPIAVSLAPSDVRGYELAAWTPLVILILLFGLWPGLLLSLTTPPVQALLGALS
>NZ_CP017717.1|WP_080043570.1|9474853_9476395_-|NADH-quinone-oxidoreductase-subunit-N
MIQQIDYFVIAPPLVLALAAGLVLLLDAFLPARRRAIIAERPGPSLPSRSGTATGLGLVTLAGILVALGFVVAQALGGGSPRSTFCVPPGLAGSGTLCSFVADGFTLVFAGMVLVAAVVIVLMSMTELAGGAIPVGEWYFLLLCTLVGAVTLPASRDLIMLVVALELVSLPVFALTALKRYDGRSSEAAVKLFVVSVVSTAIMLFGVSLLYGIAGSVYLSRLREVFGGQAMDLPAVVTVGVVLVVAGFAFKIAAVPFHSWAADVYQGAPVPVAALLSVISKAAGFAGLILVLVTALSGQAGTWAPIVAILSALTMTAGNLLAMRQRSAVRLLAWSSVAQSGYILAPLAVAATAPGAVGTSMAYLVIYAAMNLGAFAVVMLVSRAATRNELDDYRGLALRRPAAGVTLAFCLVCLAGLPPGLAGLFAKVFVFREIVGGGAGWLAVVMAVNTVIGLYYYAVWTARLFTPAGRPEPSPYRPPLTAWLAVGLALAAAVLFSVAPQLVLDLTSLSASG
>NZ_CP017717.1|WP_080043569.1|9473716_9474568_-|zinc-metalloprotease-HtpX
MHHNGLRTAILLGGLSALIIAGGAWLGGGAGARIAFVLALVSNGVAYFFSDRIALSAMRARPVSEVEQPTLYRIVRELSTQARQPMPRLYISPTVQPNAFATGRSPRKAAVCVTYGLTKLLTENELRGVIGHELSHVYNRDILISSVAGAFATMITWLSYVAVFFGGSDDDEGPGFLGALLMMVLGPVAATMVQMAISRTREFQADESGARLTGDPLALASALRKIELGARRLPLPENSRLTSASHMMIANPFSGSGFGRLFSTHPPTSERVARLERMAGYRR
>NZ_CP017717.1|WP_080043568.1|9473198_9473690_+|NUDIX-domain-containing-protein
MTVCSVDVTKIPLRRFTARVLPIDEQGRVLLLHGFDPAQPERRFWFTIGGAVEDGETLQEAAARELYEEVGIRAGVEEFTGPHAEALIEFEWGEYAFTQDQAFFAIRVGEAAAVSFDHMEQIEKDTTIEHRWWSEEELESTTEVVHPADLATLLRKIATEEPE
>NZ_CP017717.1|WP_080043567.1|9472382_9472880_+|YajQ-family-cyclic-di-GMP-binding-protein
MADSSFDIVSKIDRQEVDNALNQTVKEIGHRFDFKGTGASISWSGAGQNVIEIKANSEERAGAALDVFKEKVVKRGLSLKILDAGEPKLSGKEYRMLVSLKEGIDQENAKKISKLIRDEGPKGVKAQIQGEELRVSSKKKDDLQDVIALLKGKDLDIALQFVNYR
>NZ_CP017717.1|WP_080043566.1|9470382_9471843_+|tyrosine-type-recombinase/integrase
MDASYDVRIWKTEVYQGTEVSTYTVRWRVAKAAFRAPFRLKAQAESFKAELTVAANKGEAFSVEDGRPLSWKRDEQAVSWFTLVCAYMDAKWPYASGNHRRSIAEALTDATEAVSAGGNGRPAQKELRAALRDWVFSTRTRDGERGPRKDQSPAIRWLAPPADIEHVIRWLQNNTIDVRELTQSKHGASLTRSILDRISRTQDGTAAAGNTVKRKRQVLNNLFKFAIEINALTENPLHNITWTRPKTEEAVDPGVVTNPTQARAILSEVGKEGAMGKRLVAFFGCMYYAALRPEEVIDLRKENIATLPDAGGWGAFILTNVAPEVGTKWTDDGSARQRRGLKHRAPKAKRSVPIHPDLVALLRAHMAEFPADREGRIFTGPRRGIIRDSTYLPVWHAARKRALTPAERASGIAGRPYDFRHACVSAWLNAGVNPPQVAEWAGHGVEVLLRVYAKCISGGQAEAMRRIEAALPPVSPKPPDSPEQAR
>NZ_CP017717.1|WP_080043574.1|9486392_9486572_+|hypothetical-protein
MKVVAVLFPGLAGVGLAGLGVSPVVLLLAQGFMSLAAASGPGAFVQRTGAAVSDGARRG
>NZ_CP017717.1|WP_080043575.1|9486787_9487609_+|MerR-family-transcriptional-regulator
MQETATNRATDPGGGLTVGAAASHVGVTIRTLHHWDEIGLVSPSGRTSGGYRLYSAADIARIHRVLVYRELGLPLEDIGALLDASAVDMTVPLREQRAQLVERISRLQAMVDAVDRMIEAANAGILLSAEEQVAIFGQRWEPSWAAGARERWGDTPQWVQYAERAAGRTPEDWQRIADDIASLEADLAGAKRAGVRPGSAEANVLAERHRASIGVYFDCTLSMQVCLGRKYAADPGFAAYYDAIEPGLAGWLRDVIDANAREHGVDPESATWA
>NZ_CP017717.1|WP_155128694.1|9488029_9488584_+|hypothetical-protein
MGRPEAGPVAVPEPGPVGRPEAGPVAVPEPGPVGRPEAGPVAVPELGPMAVPELGPMAVPEPVPVAGVEPMPMAGPEAGPVAVPMAVPETVPMAGPETGPMAGPETGPMAGPETVPETGPVVGPVVGPVVGPVVGPVGKVGVVVDFLQAASSWAVAADLVRHGARSSSMRRSFTWSRSRVSGPR
>NZ_CP017717.1|WP_080043576.1|9488469_9489309_-|SDR-family-NAD(P)-dependent-oxidoreductase
MATWFITGASRGLGAEIARTALAQGDDVVVAVRNPGNVPDDLKKAGNVLTVALDVTDTAAIPAAVQAAVDRFGRIDVLVNNAGRGLLGALEEITDAEARSLFDLNVFGLVNMTRAVLPVMRRQGSGKLVHIGSRSGFEGEPGVSMYSASKFAIAGISEALSAELAPFGIQSMVVEPGVLRTDFLDVSSLSVAAHRIADYDGTPAHVTLDWAGTANHTQLGDPAKGAALIYEVTGQDTLPSHLYLGPDTLDRLQVKLRRIEEDLAPWRTKSAATAHDDAA
>NZ_CP017717.1|WP_080043577.1|9489432_9490266_-|helix-turn-helix-domain-containing-protein
MSATPLGDFLRARREAIKPQDVGLPEYGRRRVKGLRREEVALLAGMSSDYYVRLEQGRESSPSPQVVEAVARALRLDAFATEHLWRLVQPPEARTWRHGAATAVDPQLLRLMDGWTTAPAFVLGPALDILACNPMAAALHEGFSPADNLARMVFLDPAGREFYQEWERAAHSCAAELRAAYGHDPGDPRVAEVVADLSAGSPEFAELWARHDVKPKTQEGKHLRHPRVGDLHILFSAFTVNSAPHQQLVVYQAEPAGPTAQAFERLRARTENQVTVS
>NZ_CP017717.1|WP_080043578.1|9490552_9491494_-|NADH-quinone-oxidoreductase-subunit-NuoH
MLEVVLSFVVILAVFLVLPLIIGQTEHKVMAHMQSRLGPMYAGGFHGWAQLIADGVKFAQKEDVVPAAADRRIFMIAPGVALVPYLVVLIAIPIDRDAVAVNLDLGLFFVLAVMGIGVLGSIMAGWASANKYSVLGGMRSAAQLMSYELPLVLAASSVAMAAGTLSIPGIVEAWQWWWLPWQAIGAVVFFLAGLAELRRPPFDMPIAESEIIMGPMTEYTGMRFALFMLSEYVGIVVLSFLTTVLFLGGWQGPFLPGWLWTLVKVFFLAFVVIWLRVTYPRLREDQLQKLAWAVLVPLSLAQLALTGIVRVLT
>NZ_CP017717.1|WP_080043579.1|9491486_9492062_-|NADH-quinone-oxidoreductase-subunit-C
MTANDPGDAPDLRASLAESFGDRAQVSESFGDTTIDVAPADWLALLTHVRDSLGFAFFDWLTGVDEPPDVFAVVAHVYNPAAGRRLLLRTHVPRDDPRLPTAVGVYRGANWHERETFEMFGVIFDGHPNLVPLLLPDGFEGHPLRKDFILAARVAKPWPGAKEPGESGHGAPSRRKTLPPGVPADWGPPDA
>NZ_CP017717.1|WP_080043580.1|9492058_9492616_-|NADH-quinone-oxidoreductase-subunit-B
MAATDLPMPTVGPISRLAPKPMRFVLNWGRRYSLWVFNFGLACCAIEFIAASTSRHDFIRFGVIPFANGPRQADLMIVSGTVTDKMAPAVKRLYEQMPDPKYVISFGACSNSGGPYWDSYCVTNGVDQIIPVDVYVPGCPPRPEALLYGITKLQEKIAGEKLSDRYVWSRSHADHPEGPDEEPQR
>NZ_CP017717.1|WP_080043581.1|9492679_9493798_-|M48-family-metalloprotease
MSSHPPSGPPSQPLPPAPPASTGQGLAMSAGLARVAVHTLALLTHLLTPAFLLLGVYLLTRGTLFAILPALVALDLAWLLRPRPAPFPPETRPLTRETAPHLFALLDRIGAEVHAPRTDIVAISGEVNASAHAYGWRRRPVIEIGYPMWLILTPQERIALLAHEMAHSSNGDSRHGLVVGSALHSLAVLIDVTRFDWREGDGVARLFAECLLALVGLPVRGLMVAMELPLHRSSQRAEYRADELGVRAAGTSAMITLLDTTTTRAPSVISFLETSALTAKPENLWTALGAAVEAVPAAELDRRREAARSEDVRWDSTHPPTYLRIERVAALPHQEGRVPAEAAGEAVDRELGAVALHVAQAIKENARSALYH
>NZ_CP017717.1|WP_155128696.1|9494040_9494412_-|NADH-quinone-oxidoreductase-subunit-A
MDGYFGSYVLVAALLALGVAIVAGALLANRLLRPTRPTPEKLTTYECGVDPVGEGWAQSQVRYYVFTYLYVVFAVDAVFLFPWATVFDAPGYGMTTLVEMFVFLGFIALGILYAWRKRVLSWT

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Crispr_ID: NZ_CP017717_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_27

9673007-9673113

Orphan

Consensus_repeat	Method
TATGTGGGACGGGCCCGAGGCTGAGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_27

>merge|NZ_CP017717|27|9673007-9673113|CRISPRCasFinder
TATGTGGGACGGGCCCGAGGCTGAGATTGGGGCTTGAGGCCGGCTGGGGGCGGCGGTCCGCGGCGGGCTGACCGCCGGGATATGTGAGACGGGCCCGAGGCTGAGAT

>NZ_CP017717|27|24|9673007-9673113|CRISPRCasFinder
TATGTGGGACGGGCCCGAGGCTGAGAT	TGGGGCTTGAGGCCGGCTGGGGGCGGCGGTCCGCGGCGGGCTGACCGCCGGGA
TATGTGAGACGGGCCCGAGGCTGAGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043733.1\|9678806_9679250_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377816
NZ_CP017717.1\|WP_080043728.1\|9667982_9668735_-\|pilus-assembly-protein-TadB	unknown	unknown	gnl\|CDD\|227300
NZ_CP017717.1\|WP_080043734.1\|9679239_9680160_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017717.1\|WP_155130026.1\|9665463_9665604_-\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NZ_CP017717.1\|WP_155128722.1\|9662917_9663721_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043737.1\|9681206_9682169_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381319
NZ_CP017717.1\|WP_155128724.1\|9673813_9674599_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|225718
NZ_CP017717.1\|WP_080043724.1\|9664674_9665034_-\|flp-pilus-assembly-TadE/G-like-family-protein	unknown	unknown	gnl\|CDD\|274799
NZ_CP017717.1\|WP_080043738.1\|9682241_9683432_-\|MarP-family-serine-protease	unknown	unknown	gnl\|CDD\|367140
NZ_CP017717.1\|WP_043629845.1\|9657168_9657519_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP017717.1\|WP_080043735.1\|9680156_9680600_+\|DUF309-domain-containing-protein	unknown	unknown	gnl\|CDD\|377120
NZ_CP017717.1\|WP_080043739.1\|9683514_9684027_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|170047
NZ_CP017717.1\|WP_080043736.1\|9680596_9681202_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_080043732.1\|9677548_9678775_+\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|377746
NZ_CP017717.1\|WP_155130023.1\|9665086_9665431_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043729.1\|9670370_9671414_-\|chromosome-partitioning-protein	unknown	unknown	gnl\|CDD\|274798
NZ_CP017717.1\|WP_080047342.1\|9669153_9670374_-\|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl\|CDD\|200328
NZ_CP017717.1\|WP_080043727.1\|9667149_9667968_-\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224975
NZ_CP017717.1\|WP_080043731.1\|9675445_9677419_+\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_CP017717.1\|WP_080043722.1\|9656747_9657167_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080043733.1\|9678806_9679250_+\|phage-holin-family-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	7.8104e-26
NZ_CP017717.1\|WP_080043728.1\|9667982_9668735_-\|pilus-assembly-protein-TadB	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	7.64852e-15
NZ_CP017717.1\|WP_080043734.1\|9679239_9680160_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.8136e-29
NZ_CP017717.1\|WP_155130026.1\|9665463_9665604_-\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	6.24317e-16
NZ_CP017717.1\|WP_080043737.1\|9681206_9682169_-\|aldo/keto-reductase	gnl\|CDD\|381319	cd19093, AKR_AtPLR-like, Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins. Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.	1.36469e-101
NZ_CP017717.1\|WP_155128724.1\|9673813_9674599_-\|oxidoreductase	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.89174e-06
NZ_CP017717.1\|WP_080043724.1\|9664674_9665034_-\|flp-pilus-assembly-TadE/G-like-family-protein	gnl\|CDD\|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	1.64704e-20
NZ_CP017717.1\|WP_080043738.1\|9682241_9683432_-\|MarP-family-serine-protease	gnl\|CDD\|367140	pfam02674, Colicin_V, Colicin V production protein. Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.	7.85309e-21
NZ_CP017717.1\|WP_043629845.1\|9657168_9657519_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.35802e-31
NZ_CP017717.1\|WP_080043735.1\|9680156_9680600_+\|DUF309-domain-containing-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	3.50373e-23
NZ_CP017717.1\|WP_080043739.1\|9683514_9684027_+\|hypothetical-protein	gnl\|CDD\|170047	PRK09687, PRK09687, putative lyase; Provisional.	1.13299e-13
NZ_CP017717.1\|WP_080043736.1\|9680596_9681202_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.83031e-07
NZ_CP017717.1\|WP_080043732.1\|9677548_9678775_+\|Na+/H+-antiporter-NhaA	gnl\|CDD\|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	7.87612e-150
NZ_CP017717.1\|WP_080043729.1\|9670370_9671414_-\|chromosome-partitioning-protein	gnl\|CDD\|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	1.57828e-86
NZ_CP017717.1\|WP_080047342.1\|9669153_9670374_-\|TadA-family-conjugal-transfer-associated-ATPase	gnl\|CDD\|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	3.95663e-166
NZ_CP017717.1\|WP_080043727.1\|9667149_9667968_-\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224975	COG2064, TadC, Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion].	1.16449e-12
NZ_CP017717.1\|WP_080043731.1\|9675445_9677419_+\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_CP017717.1\|WP_080043722.1\|9656747_9657167_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	1.45623e-37

>NZ_CP017717.1|WP_080043729.1|9670370_9671414_-|chromosome-partitioning-protein
MHRPLAITEDPALLDDLVRIAAAAGAQLNVAPTPAHARPFWNLAPLIAIGADQAEPVAATSPPPRDQVLLVTRDTEDPDTWRKCVAVGAQSLVTLPTDERHLVDRFADAMDPDPRSGAVICLIGGRGGAGASVLAACLALRASTDHLRTLLVDADPLGGGIDALLGHEEATGARWADLVAREGRINSSALQAALPAFGDLAVLSFHRGDVDAIPPQAMRSVLEAGSRGFDLVVVDLPRHLDPSATEALSRARSTLLVATADVRGILSAVQVLSELREHTADIRAILRPGILDDDTAMTALGIPSAGTLPDQPRLTATLNRGELPRLGPRTVLGALCTSLLRDLLPPS
>NZ_CP017717.1|WP_080047342.1|9669153_9670374_-|TadA-family-conjugal-transfer-associated-ATPase
MIQHPTTLSPPEAPARQPSPSSSPISPELVEAVRVRLARTGTEPTAAQVALALRAEKSVYGDAEILAIARALCADLIGAGPLEPLLARPDVTDVLVNGPREVWTDDGTGLHRTPITFTDDGSVRRLAQRLATAAGRRLDDASPYVDARLPGGVRLHAVLPPVASGGTCISLRLPPRRAFTLNDLVTAGTVTQAAIPVLTAMVTSRLAFLVTGGTGTGKTTLLSALLSLADPTDRLLLVEDSAELRPLHPHVVRLETRPANLEGAGGVSLRDLVRQALRMRPDRLVVGEVRGPEVVDLLAALNTGHEGGCGTLHANTAADVPPRLEALGCAAGLSREAVHSQLAAALDAVIHLTRGRPDGRRRIAEICLLSRTPTGLVESIPALTFDPQGHTHPGPGYTALTQRTQL
>NZ_CP017717.1|WP_080043728.1|9667982_9668735_-|pilus-assembly-protein-TadB
MTSAVIAALSAACAIWLWTGPTPATTRLNKLLLSPTPGPPSWASMLKRLTHATTITGTITGSIPATPARRADAWRRASIELCQALAAELSAGRTASDSLTRAITAVDLPDPDLLRPVIAAARDGGDVAAALTSSAPQEGGEGIRQLAACWEVSTTAGAALAALVDRVAHTLRAAQAHRQDVAAQLAGPRTTARMLAVLPALGLLMAAALNMHPLSFLLGTFPGLMCLMTGITLDVCGLWWTNRMATHAQT
>NZ_CP017717.1|WP_080043727.1|9667149_9667968_-|type-II-secretion-system-F-family-protein
MFQLLSAICATLSAWLWLSPRTPADRLTKLHPPKRTSTSHPTAKPHETPHLPPNPLDLPPWQPPTQAPPRLGWLTRRTALPATCVGLLSALLIGGTPGALAALLITPATALFLHRRQPSQSHLDRQRTAADLPFAADLMTACLRAGRPVAAATETTAKAIGGPVGERLTWASTQLRLGADPDPTWASLAKDPAMGQLARAMSRATQSGAPMADVLTRLSDDARDASRATAVAAARSVGVKAVAPLGLCFLPAFVLLGIIPVVAGLASAIVLP
>NZ_CP017717.1|WP_155130026.1|9665463_9665604_-|DUF4244-domain-containing-protein
MSTAEYAVGTIAACAFAALLFKVVNSPEVLEMLTSLISRALNTGQG
>NZ_CP017717.1|WP_155130023.1|9665086_9665431_-|hypothetical-protein
MRSASRGSVTAETAAMLPALMVVLAAGLWAIQAVGVQLECVDAARLAARAAARGEPLEQVRAVTRAATDPNAQVAITRDPELTKVQITVEVRPSWGESLPTVRVSAAATAATEE
>NZ_CP017717.1|WP_080043724.1|9664674_9665034_-|flp-pilus-assembly-TadE/G-like-family-protein
MHPKDRGSATLWGVALMGLLMATATALATVGSVRVARHRVNSAADLSALAAAKLALIDPEGACHRASELAAANGVKLTDCQIKDDVVDVWTELPISLPLLGTRTVQGRSRAGPSTSTSN
>NZ_CP017717.1|WP_155128722.1|9662917_9663721_+|hypothetical-protein
MSGSFVVVGLRVVVAGLRVAVVGLLEGTVCFLAGNVGNASTPWASLFLGSCAVSAAFFVGWAAGGAGKVTYAAAESPDPIDPPSPSPLNALTEKPTLCPAALDGTASTALHEEPAHALSADNRPTTPDCVFDTSYDCRSGSAPLLQVTSTLSVPCLLAFTPPGASAGRRSLNVLLAYLVPVISPLRVTVKVPLGALPASNVPEIVWLAPPSAILWLGVEGPSTYSPIFSCMSPVRAETTTDEPEITSPSEGEVICPEEPACPTAVDA
>NZ_CP017717.1|WP_043629845.1|9657168_9657519_-|STAS-domain-containing-protein
MDLKLDHRTEDRLTIVEVEGEIDVYTAPRLRELLIDLVNKGNFHLLVNMEKVDFLDSTGLGVLVGGLKRVRAHDGSLELVCTQERILKIFRITGLTKVFGIYASVDEAKEAHGKDK
>NZ_CP017717.1|WP_080043722.1|9656747_9657167_-|ATP-binding-protein
MATVELTFSALPAHVRTARLVATAIARRTGVQESLLDEVRLAVGEACSRAVEAHRAHCPGEPIRIELRDDSGRFEVTVSDQAPSDEIKQEQPLDLGMLSDSFMSNFGIAVITGLADDVQVFPSPKGTNIRMSWPAAVGV
>NZ_CP017717.1|WP_155128724.1|9673813_9674599_-|oxidoreductase
MSDPDPLAVIAQLPGVPEAVDEARQAVDRLYRHRVLRRASPAVSTESSLRGARASAAIEGADVPLDVLRRDEAHDPLVQGALRASAEMGRLGSTWRKAPRQVLARLHAVAAAGLAPQEALGRPRATDDAPDPLALGPSLSAVDTAARMEGLLSLLSNPTKAPAIVLAAVVHAELAVLRPFGTADGIVARAAGRLTLVEYGLDPKSLVAVEVGHLELPYAEALRAYLGGSPEGVAAWVQHCASAVTLGVRETTAICEAMQRG
>NZ_CP017717.1|WP_080043731.1|9675445_9677419_+|acetate--CoA-ligase
MAPETAGNETQALSNLLKENRRFEPPADLAAAANVTEAAYNEAAADRLAFWERAAERLTWAKRWDTTLEWKAPFAKWFVGGELNVAYNCVDRHVEEGRGDKVAYYWEGEPEGDTRTITYSDLQREVSKAANALVELGVGKGDRVAIYMPMIPELPVAMLACARIGAIHSVVFGGFSASALKSRIDDADAKVVITADGGYRRGKPSALKPTVDEAVAECPQVEHVLVVRRTGQEVATSDKDVWWHDLVERQSDQHTAEPHDAEDPLYILYTSGTTGRPKGILHTTGGYLTQTAWTHHAVFDLKPETDIYWCTADIGWVTGHSYIVYGPLANGATSVIYEGTPDTPHRGRFWEIVQKYKITILYTAPTAIRTFMKWGDDIPAKYDMSSLRILGSVGEPINPEAYVWYREHIGGERCPVVDTWWQTETGAIMISPLPGVTAGKPGAAMRPLPGVVADVVDDQGNSVPNGGGGFLVVREPWPSMLRTIWGDDQRYIDTYWSRFEGMYFPGDGAKKDEDGDLWLLGRVDDVMLVSGHNISTTEVESALVSHPKVAEAAVVGATDPVTGQAIVSFVILRGTAEESEDIAAELRNHVAKTLGPIAKPRQILVVPELPKTRSGKIMRRLLRDVAENRSIGDVTTLADSTVMNLISEKLPSAKSED
>NZ_CP017717.1|WP_080043732.1|9677548_9678775_+|Na+/H+-antiporter-NhaA
MPTGRRRSVRTEKWPFPTGARYARALAEALRTETIGGVIMLAAAIVALLWANVSNDSYEALRHASLGPMELYQWAQHGLLTIFFFVAGLEVKEEFVHGELSNPRKAALPIIASLAGMVLPAIVFLLVSWGAQDAARGWAIPTATDIAFALAVLAVTAGAMPAALRAFLLTCAVVDDLGAIAVIAVFYTERVNVPMLVLGAALVAAYGLLQRRLVTSPWALVPLAVAAWYCVEVSGVHATVAGVALGLMTRVTTAPHESRSPAEAADHYFRPVSAGLAVPVFAFVSAGVKLDGSSVGAIFADRVVLGVMAGLVLGKFLGVFGGAWLSVRLGLARLSEELHWRDMAAVSLLAGIGFTVSLLIGDLAYGDDRQRAEAVTTGILAASVIASILAAVLLKIRVRKRRIALDDV
>NZ_CP017717.1|WP_080043733.1|9678806_9679250_+|phage-holin-family-protein
MPQTPEEESLGSLVAQASSHISDLIRSEIELAKTEFRFDAKRVGTAAGLFAGAAFAAHLCLILASFTIAYALAQVMPNWLAFLIVTVVYLVAAGLAVLVGVRRLKGLAGMKRTARSIKDLKEIATPDGQAPLPALGPDREPVTRDGS
>NZ_CP017717.1|WP_080043734.1|9679239_9680160_+|alpha/beta-hydrolase
MAPDESVVHIEGPWTHRAVHAGGTRFHVVEAGEGPLVLLLHGFPQFWWTWRHQLVSLAAAGFRAVAPDLRGYGGSDKPPRGYDLPTLAADATGLIRALGETGAVVVGHDWGGLLAWTMAAQDPKCVRRLVAVSAPHPLRLRNALLTDPFGQLRASRRTIGFQLPLLPERRLTRHDAALVGRLLEERSRPGWPEQEESRTYREAFRIPAVSHCALEYHRWFGRSQLRPDGRRYARLMRTEVEAPTLHLHGALDPSVLPRTAQGSSRYVAAPYRWRLFEGAGHFPHEEIPDVFDTELLGWLDDPEPDR
>NZ_CP017717.1|WP_080043735.1|9680156_9680600_+|DUF309-domain-containing-protein
MRDRDPEGRPRNARPRDAYGRPLPYGSPGMPRVPDDYAPTTEQALADGRRFLEEGLPFNAHEVFEGRWKCAPEEERELWQGLAQICVGLTHLQRGNGRGAMTLFSRGAAKAQSYGGAYDPVGKAASSLTQDTDPAEAIALILDKLPT
>NZ_CP017717.1|WP_080043736.1|9680596_9681202_-|TetR/AcrR-family-transcriptional-regulator
MPRTARRDRYHHGDLRAALIDTAMELIAEQGAQGFSLAEASRRLGVAVSAPYRHFADRDELLVAVGVRTGELLVAAVTAERGGDAPEERLVAVVRGYVRFAARHRALFETLLNLITPEGEPELDRAMRPVKAAFHDAATALSGGDPAAAQALGMAVIATADGHAGLLHRGTFGTGEEAVETAVRQAAAATRALVAGRAALG
>NZ_CP017717.1|WP_080043737.1|9681206_9682169_-|aldo/keto-reductase
MVRLGRTDIEISPVGLGCMQFAGTGYVARWMVRPIDQESATSVVRAALGGGVTWFDTAEMYGNGRSEEMLASALKACGVAPGEVTVATKWVPLGRTAASITRTIGDRLRHLGGFPVDLHQIHMPTGSLSSLPAQLKAMALLLKAGRIRSVGVSNFSARQLELAHRVLAAEGVTLASNQVRISLLHRDVERDGVLDTARRLGVTLIAYSPLEGGLLTGRFHDDPALARSAPVMRRFFGRRELSAQGLARTRPLIEELRAIGKAYGASVSQVAVNWVITRYGDTVVAIPGASKPRQAAEAAGAMGFRLTEAEIGRLNALSLP
>NZ_CP017717.1|WP_080043738.1|9682241_9683432_-|MarP-family-serine-protease
MRGDLLDLILIGLVIAFGISGYRQGFIIGAMSFVGFVGGAVLGVFIAPPVSKAVVDGDTPQALLAIVIVFLSATIGQFASSTLGAVVRSHVTWEPAKMADAIGGTFASALSVLVIAWLIGSLIVSTAFSPLVDQVKNSALLTTVDDAIPQAARNWQQPFKKFIDRSEFPPVFDAIGAGALIDVQPPDQSVLQGAKLGRAREAIVKVQGDAQSCNKHIEGTGFVYARGRIMTNAHVVAGVTRDLQVIDHNGDRHAATVVRYNPRRDIAVLYVPGLDLPQLSFDGEGRRGDNAIIAGFPKGKGFTAEPARIGSQLEAEGPDIYRENTVRRKVYAIRGQVLPGNSGGPLLTVDGQVYGVIFAAAINEEQTGYVLTAEEVAPDASAGRNDTTPASTQECD
>NZ_CP017717.1|WP_080043739.1|9683514_9684027_+|hypothetical-protein
MPPDEGTVRELIQAALRDTDPDGPLRWHVISLLRQRGDLESFIEARRLCAADTVEERLLGVDIMGMLRPFVDRTLPVLRYLAASEDDAVVLYSVLIAFGHLADPRSLPSVIDLAGHMDPRVRYGAAYALQHVLGDPPDRAGLETLRTLAADSDADVAGWAALGVALRSAR

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Crispr_ID: NZ_CP017717_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_28

9792907-9792992

Orphan

Consensus_repeat	Method
CTTTCGTCCGAACGGCGCTGTTTCGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_28

>merge|NZ_CP017717|28|9792907-9792992|CRISPRCasFinder
CTTTCGTCCGAACGGCGCTGTTTCGTCCGAACGGCCGCTGTTTCGTCCGAACAGCCGCTCTTTCGTCTGAACGGCGCTGTTTCGTC

>NZ_CP017717|28|25|9792907-9792992|CRISPRCasFinder
CTTTCGTCCGAACGGCGCTGTTTCGTC	CGAACGGCCGCTGTTTCGTCCGAACAGCCGCT
CTTTCGTCTGAACGGCGCTGTTTCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043825.1\|9797014_9797758_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|235816
NZ_CP017717.1\|WP_155130032.1\|9794093_9795617_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080043817.1\|9785593_9786859_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP017717.1\|WP_080043821.1\|9791323_9791896_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP017717.1\|WP_080047349.1\|9793001_9794054_-\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179559
NZ_CP017717.1\|WP_155130029.1\|9790336_9791218_+\|chitin-binding-protein	unknown	unknown	gnl\|CDD\|376983
NZ_CP017717.1\|WP_080043830.1\|9803492_9804581_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340825
NZ_CP017717.1\|WP_080043831.1\|9804600_9805863_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749
NZ_CP017717.1\|WP_080047348.1\|9783467_9784682_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NZ_CP017717.1\|WP_155128751.1\|9797962_9798304_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043829.1\|9801646_9803464_-\|DUF4434-domain-containing-protein	unknown	unknown	gnl\|CDD\|373094
NZ_CP017717.1\|WP_080043827.1\|9798513_9799872_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP017717.1\|WP_080043824.1\|9795867_9796887_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182137
NZ_CP017717.1\|WP_080043822.1\|9791985_9792897_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187572
NZ_CP017717.1\|WP_080043818.1\|9787060_9788350_+\|GTP-cyclohydrolase-IIa	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043820.1\|9789328_9790240_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|183067
NZ_CP017717.1\|WP_080043815.1\|9782000_9783110_-\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213364
NZ_CP017717.1\|WP_080043828.1\|9800419_9801085_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NZ_CP017717.1\|WP_080043816.1\|9784678_9785515_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_CP017717.1\|WP_080043819.1\|9788728_9789160_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|238779

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080043825.1\|9797014_9797758_+\|glucose-1-dehydrogenase	gnl\|CDD\|235816	PRK06500, PRK06500, SDR family oxidoreductase.	6.77127e-95
NZ_CP017717.1\|WP_080043817.1\|9785593_9786859_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	3.75322e-179
NZ_CP017717.1\|WP_080043821.1\|9791323_9791896_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.28057e-10
NZ_CP017717.1\|WP_155130029.1\|9790336_9791218_+\|chitin-binding-protein	gnl\|CDD\|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	2.98049e-64
NZ_CP017717.1\|WP_080043830.1\|9803492_9804581_-\|glycosyltransferase	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	5.13047e-28
NZ_CP017717.1\|WP_080043831.1\|9804600_9805863_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	2.48738e-176
NZ_CP017717.1\|WP_080047349.1\|9793001_9794054_-\|histidinol-phosphate-transaminase	gnl\|CDD\|179559	PRK03321, PRK03321, putative aminotransferase; Provisional.	0
NZ_CP017717.1\|WP_080043827.1\|9798513_9799872_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	4.29672e-55
NZ_CP017717.1\|WP_080043829.1\|9801646_9803464_-\|DUF4434-domain-containing-protein	gnl\|CDD\|373094	pfam14488, DUF4434, Domain of unknown function (DUF4434).	0.000962856
NZ_CP017717.1\|WP_080043824.1\|9795867_9796887_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	9.57233e-38
NZ_CP017717.1\|WP_080043822.1\|9791985_9792897_+\|SDR-family-oxidoreductase	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.43387e-112
NZ_CP017717.1\|WP_080043820.1\|9789328_9790240_+\|EamA-family-transporter	gnl\|CDD\|183067	PRK11272, PRK11272, putative DMT superfamily transporter inner membrane protein; Provisional.	1.43915e-65
NZ_CP017717.1\|WP_080047348.1\|9783467_9784682_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP017717.1\|WP_080043815.1\|9782000_9783110_-\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.95871e-163
NZ_CP017717.1\|WP_080043819.1\|9788728_9789160_-\|sulfurtransferase	gnl\|CDD\|238779	cd01521, RHOD_PspE2, Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins.	5.4138e-54
NZ_CP017717.1\|WP_080043828.1\|9800419_9801085_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.64226e-17
NZ_CP017717.1\|WP_080043816.1\|9784678_9785515_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	2.97945e-180
NZ_CP017717.1\|WP_155130032.1\|9794093_9795617_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.70452e-96

>NZ_CP017717.1|WP_080043822.1|9791985_9792897_+|SDR-family-oxidoreductase
MRVFVTGATGHIGSAVVPELLSAGHQVVGLARTDDSAAALKALGAEARPGDLDDLDGLREAAADADGVIHLAFKHDAMMAGDIATAVEADLAALRAFREALAGTGKPFVGTSGTALLAHASAGPATEDVVLTPGPGLAARIGAEKLVAELAESAIRSSVVRLPPTVHSELDRAGFVPMLIATARNKGVSGYLGDGANRWPAVHTLDAARVYRLALERAPAGSRLHAVADEGVPLRHIAEAIGRHLDVPVAAIPQDQAEAHFGFLAAVVPLDNPARSEHTRRLLGWQPAHPGLLADLDLGHYFA
>NZ_CP017717.1|WP_080043821.1|9791323_9791896_-|TetR/AcrR-family-transcriptional-regulator
MGRWEPNARERLERAALELFEERGYDSTTAAGIAERAGLAKSSFFRHFADKREVLFGGQEVFNRLVADAITGSPPEATPIEMLGAALDAVAVVFTDERRALARRRQAIVAGHDDLRERELLKLAALTGCLSDALRGRGVPDPAAGLAAELAGLAFRNAFARWIDPANDQGFATIARQELKALVAATATLT
>NZ_CP017717.1|WP_155130029.1|9790336_9791218_+|chitin-binding-protein
MAAGPAAASIAGPAAPAAVPAAVPAAAGLTVRAHGALEEPASRAAACGAEGSAAAARSAACRAAVRASGGVLPRAWDDLRVPDVAGRDRQVIPDGKLCSGGLPAFKGLDLARADWPATPVRPGARFTFKYRGTIPHRGTFRLYVTKKGYDPAKPLRWADLEREPFLTATDPAFKNGSYTIKGRLPARTGRHLIYTIWQNSDTPDTYYSCSDVLFRPSTGPSTGPSTGPSTGPSTGAAGAGAAGAPPVRQAAVSTQARARRADASWLVGGSVVLAGCAGTMGLLIGRLRHRRPN
>NZ_CP017717.1|WP_080043820.1|9789328_9790240_+|EamA-family-transporter
MIWGALAIVYVVWGSTYLGIRIAIETMPPLFHGAMRFVSAALLLAAFLLVTKRLAPFRMTLKQLGGAALVGLLLLTGGNGMVAVAEQHISSGLAALLVASVPLWLVVLRLVFRDRPAMLTLVGVLVGFGGVAALSLNGGGESAGTTGIVIILLGSVSWSIGSFLSSRIPMPPNVWTASAIEMLAGGAGLAIVGASIGERLDVAAVSGRSWAALAYLVLVGSLVGFTAYTWLLGNAPISLVSTYAYVNPIVAVILGVLVVNEHVTVQIVLGGLVILVGVALVVSTERRARARAALEPEKVASSA
>NZ_CP017717.1|WP_080043819.1|9788728_9789160_-|sulfurtransferase
MSNTAAIAHFSARLSFETDVSDVAADLLAGTPGLVVVDSRSRESWDQGHIEGAVHLPTREIAARAGAMVPKDAAVVTYCWGPGCNGATRAALEFAKLGYQVKEMIGGFEYWAREGFPVETASGVSRRPVDALTAPISGAACAC
>NZ_CP017717.1|WP_080043818.1|9787060_9788350_+|GTP-cyclohydrolase-IIa
MTPDLTIGVVGPHDLVERVMLMGHAAAPLPCRLVAAAYRDEQEAPDKVTRLGPGVDACLFASPVPYDLARRSGVLTMPATYVQLGGAALVAALAKAALDPRMDPQRVSIDVVSRADVEEAYTDLGIPAADVHSRDEPGATGTIAAYHERLARQGATTGALTCLPAVAERLHTAGVPVIRIRPTSAAVRTALHTAALLGAHHRLEESQLTVVLVEVPTLREPVRRAAPRYWRDELRLSLHRLLVQEANRINATVWPIDDHSYLVTATRGSIAAATDGFRVLPFAARIRDELGLAVEVGVGMGRTTHDAESHARAALARTQAGKQAQGFAVDREGRALIPAPRMPPAGATALKPKGVEVLARLAAKLEGGDTVVDAEGAGKMLGVTPRTARRLLRTLVDEGLAWPLPPNRTPQPGRPRQLYRLIVEKLGPR
>NZ_CP017717.1|WP_080043817.1|9785593_9786859_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MVRYRVRGGNALRGTAFIQGAKNAVLPMIGAALLAPKGRTVLRNVPIIEDVRRAVELAEAVGAYVELHESERTLVIDASRVNSPVLPAEIARRFRGSVLFTPALLHRLGEAVVEGVGGCNLGSRNLDFHYLGYKRLGAIVDEGETVIHVKASGLTGATLYLDTPSHTGTENLIMAAALAKGTTVIENAALEPEVLDVIDMLTKMGARISGGGTGFITVEGVEELHAVEHTVMPDRLDAGVFAMAAALTKGEVSLVGTGLDLGVVRYKLEQMGVEFHRQGAVLHVRCDGPLRPINIITDTYPGFATDLQSPMMTVAALAEGTSYIHERIFDGRFALAGELNKMGANVEVDGSRAIVRGRTPLTGAQVTAHDLRSGIALVLAGLAAEGETLIDSGYLIDRGHAHLAARMRALGADITREISER
>NZ_CP017717.1|WP_080043816.1|9784678_9785515_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MKHLHSGKVRDLYETDDGLLLMVASDRMSAFDYILEPEIPDKGAILTQMSLWWFDQLKDVVPNHVVAPGDEPRSVLCRPLKMVQVECVARGYLAGGGLNEYRADGTVSGVRLPEGLEDGSRLPEPIFTPSTKAPQGQHDEPMSYEQVVAEVGAEVAAELRRVTLAVYTRGAEIARERGIILADTKIELGWDADGVLTLGDEVLTPDSSRFWPADEWKPGRSQPSFDKQFVRDWLLSPESGWDKSSGNPPPRLPDHVVERTRQRYLEAYERVTGSPFSG
>NZ_CP017717.1|WP_080047348.1|9783467_9784682_+|phosphoribosylamine--glycine-ligase
MRVLVIGSGGREHALCRSLSLDPQVSELHCAPGNPGIEQVATVHAVDPLDPGQVAALAGRLRVDLVVVGPEAPLVAGVSDAVREAGFACFGPSKDAAMIEGSKAFAKEVMKAADVPTARARVCVTEEEAAAALDEFGAPYVVKDDGLAAGKGVVVTDDRDQALAHARACERVVIEEYLDGPEVSLFALCDGSTAVPLQLAQDFKRAYDGGEGPNTGGMGAYTPLPWAPDGLTEQVMREVVHPTIGELSRRGLPYQGVLYVGLALTSKGPKVVEFNARFGDPETQVILDRLETPLGGLLMAAATGELGLDPVFKGGSAVTVVIAAENYPAAPVKGDPITGLEPTPNAYVLHAGTKRDGDAVVSDGGRVLSVVGHGPDQDSARRAAYDLVGRVKLRGSFHRTDIAR
>NZ_CP017717.1|WP_080043815.1|9782000_9783110_-|magnesium/cobalt-transporter-CorA
MRSSTLFRRINRHTVPSRAPHSLTKPVREVCVPPVDSLVEFGAYVQGKKVSAQGIEEALGLVRAHNQSNSGASAFVWVGLHEPAAPEVEWLAEVFGLHPLAVEDAVKAHQRPKVERYGESLFMVLKTIAYLDHDELTATSEIIATGEIMVFLGADFVVTVRHGKHCSLAGVRERLEDKPKLMNRGPTGVLHAISDHVVDQYLQVADLMQLELEEVEATVFADVSSRDINRIYQLKREMLEMKRAITPLQSPMAALPQRRVIPSEMRDYFRDVGDHLSRVCEQVESSNELCSSILQAALARSNALANEDMRKISSWVAILAVPTMIAGIYGMNFDFMPETKAVWGYPAVLAVMVTVCVLLHRGFRRNGWL
>NZ_CP017717.1|WP_080047349.1|9793001_9794054_-|histidinol-phosphate-transaminase
MLDTMAAYKPGKAVAAPDGRSYKLSSNESPYDPLPSVVEAIAEGARQVNRYPDPASVKLTEAIAERFDVPAEHVALGAGSVTVAQQLFETVGEPGAEVVYAWRSFEAYPLLADLAGVTSVTVPLAGEDHDLNAMAEAITDRTRMVFVCNPNNPTGTAIRRAELEAFLARVPEDVLVVLDEAYREYVRDEDVPDGLTLYRDRPNVAVLRTFSKAYGLAGLRVGYLIAPEPVATAVRKTIIPFAVNHLAQVAAVASLRAEDELLDRVERVVKERTRVREALIAQGWTVPPTEANFVWLRLGAHTPAFAAACAEQGVAVRPFGEEGVRVSIGSPEANDAFLAVTGELVGKMNG
>NZ_CP017717.1|WP_155130032.1|9794093_9795617_-|protein-kinase
MGTVWRAMDELLRQEVAIKEVRLPPNLDESARSELVDRTLREARAAAALRDHPSIVTVHDVVLDDGRPWIVMELVRGRSLDRVVRDDGPLPPARVAGIGLRMIEALSAAHASGILHRDVKPANVMLTDDGRVLLTDFGIATIAGDVALTQTGLLSGSPGYIAPERLRGEPDGPPADLWSLGATLYLAVEGAPPFSRHNEAAVLAAVLMQEPAPFRLAGPLGPALAAILEKDPARRCSPEQATAWLTPIAQGTQGAQGLQSAQSIQSTHPPGVSAAHPPVGPQPLTQDSGPRRRRRTKAVVGAALALVLLVTASVVVIPQLFPNVIRLIGYALSPPSTTFPTFKPRPTASATPSTPLIGEFEACELLTTTQVRSLFGHTVKRQWLTDASCSWRGGTFQVLTVMAYRAPSTSVAGTMHEQTVKYMRDEPKRNPGTKFRERPDIGEDAYSHTGRLLEGLPSYMTKVAFTVSNVSVTVSLQRGRPGDAGSQKVAKLVADALRKRVQRAGTG
>NZ_CP017717.1|WP_080043824.1|9795867_9796887_-|LysR-family-transcriptional-regulator
MTEYSEEVSEIAASSPPVGAGTDPGAGPGPGPGASTEAEPEVHFDLDLRLVRYFTVVAEHLNFARAAAALHLAQPSLSRQIQRLEEMLGVRLLERTTQGSRLTAAGAAFLPQAQALLHAARRAALSARAAAPPRTITVGYLEDLVITPAVRDLRRRHPDAHVRTRHLDWDEARALPDGQVDVLVARTPLPIPGDGLTETVLYDEPRVLLVPAGHRLAGEESLTRDDFAGEPLVACAGVAPMWARFWRLEPRPDGQPAPLALVVDTFEDKLELVAEGRALAVVPAGDRRVTLRDDLATVPVEGIEPCRVVVVHRTGDRDPLVADFVTSARTFLTSPWTAG
>NZ_CP017717.1|WP_080043825.1|9797014_9797758_+|glucose-1-dehydrogenase
MGEYEGKKVVITGGSSGFGLATARLLAAGGARVLITGRNQDTLDAAREQLGGDAIAVRSDASSAPDIDALADRVKAEFGSIDALFANAGVNGFAPFESTSEELFDQLMAINAKGPYFTVQKLAPLLAEGSGVVLTTSVANVLGLPMLSAYAASKAALRSMTRGLARELLPRRIRVNAVSPGPIDSGILEKSMPKEAAEQMKAQMAADNPMLRMGTPEEVARAVVFLAFEATYTTGAELTVDGGGSQL
>NZ_CP017717.1|WP_155128751.1|9797962_9798304_+|hypothetical-protein
MSRYTQYAWGRVAVALTAPLATILLAAPAAQAASGTYTWITPAGQPFQVVEPPSDTCLELSGGAIRFSNDTTDTAFLYGTPDCSGGWALVGVGATWDAPTGVQAFAVRLGSTQ
>NZ_CP017717.1|WP_080043827.1|9798513_9799872_+|serine-hydrolase
MNGAAITAGGPQRTSNESNDVRTRVTGARPTRTLRRAGVAALAAALLAGAATPAMAATTPVDSRTSAGSRTTADGNTPVSQNAAAAAATSEQNRPELQQAIQAFVDAGFLGIQARVRYENGEWVGTAGSSELGQPAKPPANGRFWVGSVTKTFTATVMLQLVSEGKLGLDDPVATHLPEFGLDERITVRMLLQHTSGLFNYTGDFDPDGAWVLGIPATGDDWLANRFHAYQPEELVRVALSKPPRFEPGTDQNYTNTNYTLARLVIEQVTGRPFADELHRRVLRPLGLKNTVVPGNRTQLPGPHAHGYYRYQDATGKWKVVDVSRQNMSLLAGAGDMISTTKDLQTFFSALNSGRLLPAPLLAQMRTPHPKQSYGFGLFVQDLGPGCGTVYQHNGSPPHAYGALMYSSPDGRKTLTASLNYVDDATRSPAAKFPQALDTLIKTVFCDGQAAG
>NZ_CP017717.1|WP_080043828.1|9800419_9801085_-|NUDIX-hydrolase
MVPSIPVSVDLVVLTVRNQALCALVWRRDNPPFLRRWSLPGGFIQLDEDLPAAAHRLLAERAGLPGAPVHLEQLQTYGYPDRDPRQRVLSVAYLGLAPDLPASEKAHMSWQPIDSLTVMAFDHRRIMLDGIERARAKLEYTSLGAAFCPPEFTVADLRRVYEIVWGRPLDPRNFHRKVTKAEGFLLETGGTTTRDGGRPAKLYRRGPAELLHPPMLRSLKE
>NZ_CP017717.1|WP_080043829.1|9801646_9803464_-|DUF4434-domain-containing-protein
MRWLFLVAGAAILAVVAAVIIVLPSGDPAPVASTSAAPKPTKTEPTPKVSEFTDDCGTFDTDKKAPYAVTGYWITPQSNPCTWRKQLQEIHGVGGDTIIRIGYGLQFRTVNDAGQILKEGEVDPLYKPCEEDGLSCHDAALSDLQKANPENRVGRVYVYRTDELFGQDLFRCPGMEHAVQAGKRTYYRLLTQPDGSDDATCDFESKARSYDMILVAGSNKGEDSLTQLLDLADQFGMRVFPALPLAPRDSKNKIRAEKRHLGTLTTLTRRILQDYGARFEGRDSLGGVYQPFEVQMSATLATNPTLEVYADQHTIVEQELRKPILISPYLDARKRVPFGQTPKQVAEGFKALVKTGVGIIAPQDSRGTGKVGLFWPDERDQEVDERLRPMVGESTYDTAYHGSTRDYYREMAAAREELIDEGYHVELWANVEAFEPSGDRPCAPSGTRGKTDKKRLDQAVTMAGRYVQKIVSYMWSDFMTCGDPSLETEIARDWQRPIAVDAIRRPRDIQDGVEVRGYNLKNSTITITWSGGTKEMVVSSVGWLDEDPIEEELPVGMATAWVPFDWTQVPGGEWVRIGVKTSTGQAATEPLHVRIPTQAAGTEGG
>NZ_CP017717.1|WP_080043830.1|9803492_9804581_-|glycosyltransferase
MHVLVMTVVHNPEDARILHRQIRALVDAGHEVTYAASFTAHGVVPRPWVNGVDLPRAAQRKRVAAVWAARRLFKRMRDKVDLVLIHDPELLFAVWGIRNRPPVVWDVHEDTPATLSLKPWLPAPLRPPVRFLARMLEGTAERHMHLLLAETAYAGRFKHAHLIVPNETWVPDSVTPPGDDRIVYLGWLSKARGVVEAVEVAKLLQPYRVAVELIGYADPQSRPMLNQAVTEGLLEWRDFMPNDEALKRLDGALAGLSLLHDEPNYRHSMPTKIVEYMAHGIPVITTPSPRAVELVERYDSGVVVPWEDPKAVAQAVLTLRDDVRERRAQGARGYAAARANHHWPNSAKRFVAQLEAWAGVKP
>NZ_CP017717.1|WP_080043831.1|9804600_9805863_-|nucleotide-sugar-dehydrogenase
MTEIDLTVIGLGYVGMPLAKEAVGAGLRVVGLDVDPAKVDALNAGQSYIDDLSDADLEHMLANGFSATLDESVLARSNTIVICVPTPLDDDHRPDLSAVEGATKAVARNLSKGTLVVLESTTWPGTTDELARPLLETSGLKAGEDFHLAFSPERIDPGNPKFGLRNTPKVVGGYTMTCRDRATAFYGRFIEQVVPVSGTREAEMAKLLENTYRHVNIALVNEMAIFCDELGIDLWEAIEAAATKPFGFHKFLPGPGVGGHCIPVDPSYLSYTVRKLGYPFRFVELAQEINERMPSYVVARVQRLLNRHKKPVNGARVVMLGVTYKPDIADERETPALPVARALLELGAELSFADPYVKEWAVDGTPVPREEDLAEAVINADVTLLLQQHAAFDLDMVEAKAKLVLDTRGVLAEGERVERL

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Crispr_ID: NZ_CP017717_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_29

9954586-9954672

Orphan

Consensus_repeat	Method
GCCCTGACCTTGGCCAGCCACTCGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_29

>merge|NZ_CP017717|29|9954586-9954672|CRISPRCasFinder
GCCCTGACCTTGGCCAGCCACTCGCCCGCGTACGCGGTCAGGTGCTCAGACCTGCCCAGCCCTGACCTTCGCCAGCCACTCGCCCGC

>NZ_CP017717|29|26|9954586-9954672|CRISPRCasFinder
GCCCTGACCTTGGCCAGCCACTCGCCCGC	GTACGCGGTCAGGTGCTCAGACCTGCCCA
GCCCTGACCTTCGCCAGCCACTCGCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080043988.1\|9964643_9965750_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NZ_CP017717.1\|WP_080043973.1\|9945294_9945657_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP017717.1\|WP_155130038.1\|9946037_9946364_+\|calmodulin-binding-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043987.1\|9964230_9964626_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043974.1\|9948811_9949768_+\|NAD(P)H-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176180
NZ_CP017717.1\|WP_080043977.1\|9951468_9951672_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP017717.1\|WP_080043984.1\|9962352_9962892_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP017717.1\|WP_080047361.1\|9955622_9956018_-\|DUF4446-family-protein	unknown	unknown	gnl\|CDD\|379655
NZ_CP017717.1\|WP_080043983.1\|9960356_9962318_-\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|274589
NZ_CP017717.1\|WP_080043976.1\|9950447_9951245_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP017717.1\|WP_080043972.1\|9944331_9945177_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239217
NZ_CP017717.1\|WP_080043978.1\|9951913_9953281_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043986.1\|9963695_9964043_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP017717.1\|WP_080043985.1\|9962936_9963662_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133022
NZ_CP017717.1\|WP_080043989.1\|9965813_9966506_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP017717.1\|WP_080043981.1\|9956064_9957258_-\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|172015
NZ_CP017717.1\|WP_080043979.1\|9953244_9954507_-\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NZ_CP017717.1\|WP_155128785.1\|9966600_9966774_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080043975.1\|9949773_9950295_+\|bacterial-proteasome-activator-family-protein	unknown	unknown	gnl\|CDD\|378489
NZ_CP017717.1\|WP_155130041.1\|9946420_9948172_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223531

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080043988.1\|9964643_9965750_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	6.5426e-48
NZ_CP017717.1\|WP_080043973.1\|9945294_9945657_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	9.27353e-20
NZ_CP017717.1\|WP_080043974.1\|9948811_9949768_+\|NAD(P)H-quinone-oxidoreductase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.89501e-178
NZ_CP017717.1\|WP_080043977.1\|9951468_9951672_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	6.21762e-36
NZ_CP017717.1\|WP_080043984.1\|9962352_9962892_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.11573e-37
NZ_CP017717.1\|WP_080047361.1\|9955622_9956018_-\|DUF4446-family-protein	gnl\|CDD\|379655	pfam14584, DUF4446, Protein of unknown function (DUF4446). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 165 and 176 amino acids in length.	5.05083e-27
NZ_CP017717.1\|WP_080043983.1\|9960356_9962318_-\|DUF2029-domain-containing-protein	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	5.6839e-10
NZ_CP017717.1\|WP_080043976.1\|9950447_9951245_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	6.31057e-58
NZ_CP017717.1\|WP_080043972.1\|9944331_9945177_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	6.54483e-12
NZ_CP017717.1\|WP_080043986.1\|9963695_9964043_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	6.29923e-34
NZ_CP017717.1\|WP_080043985.1\|9962936_9963662_-\|glycosyltransferase	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.50505e-27
NZ_CP017717.1\|WP_080043989.1\|9965813_9966506_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.5702e-91
NZ_CP017717.1\|WP_080043981.1\|9956064_9957258_-\|DUF2029-domain-containing-protein	gnl\|CDD\|172015	PRK13375, pimE, mannosyltransferase; Provisional.	7.09899e-37
NZ_CP017717.1\|WP_080043979.1\|9953244_9954507_-\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NZ_CP017717.1\|WP_080043975.1\|9949773_9950295_+\|bacterial-proteasome-activator-family-protein	gnl\|CDD\|378489	pfam10759, DUF2587, Protein of unknown function (DUF2587). This is a bacterial family of proteins with no known function.	1.4798e-94
NZ_CP017717.1\|WP_155130041.1\|9946420_9948172_-\|AAA-family-ATPase	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	1.55787e-51

>NZ_CP017717.1|WP_080043979.1|9953244_9954507_-|serine--tRNA-ligase
MIDLRTLREDPDRLRASQRARGEDDSVVDTLLDLDERRRSALTSFESLRAEQKSMGKSVSKAQGEEKAALLQRAKELAGQVKAAESEAEKLGAELDEVLQTVPNIVEEGAPPGGEDDYVVLETHGEPRTFDFEPKDHLELGEALGAIDMERGAKVSGSRFFFLKGVGARLQLGLLNMAMQQAIEAGFTPMITPVLVKPETMQGTGFHVAHDKEIYRLPEDDLYLVGTSEVSLAGYHAQEILDAGDLPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFSYVRPEDAHEEHQRLLGWEKEMLAKIEVPYRVIDTAAGDLGMSAARKFDCEAWIPTQGRYRELTSTSNCTEFQARRLAVRYRDKDGKPQHLATLNGTLATTRWIVAILENHQQADGSVVVPQALRPYVGLDVLEPAK
>NZ_CP017717.1|WP_080043978.1|9951913_9953281_+|hypothetical-protein
MTIAGVLVLLVNDHLLKQSWPGPVTGKLSDVAGLVVAPALVALLFWRRADLAATVLTGVLFTAVKTTETGAELASQAWTLVAGPSRVLADPTDLLALPALALAWWVRRRTLGHPGSARRRIIVTMPLAVLAVAATSGPIPPPSATAVEVSPSGRITVHTDRMLDLVSEDGGRTWTERTGEDKGRPAQSAQCVPWQPARCYRLVQGRMAVEQSDDTGVTWHTSWEPSADDLKRLSRQYRPDGLRSRSLAVREQPNGQHVVVVADGMAGITVRDASGTWRQIGWPGTEAAEVGVEPEQNVAIFLAACMLFAGAGAGMRQFTLAYTGSALAACSGLLLLVRSEVLPPYPEVVLGVPVVLIGAALLLAGVTVCLVLAIAGKARPASAAIGALAAPLVYGAVYLPFTGWARGTPDSYTLALALAVLLTGLVVLASAAAIRRDARRATSGYFAGSSTSRPT
>NZ_CP017717.1|WP_080043977.1|9951468_9951672_+|cold-shock-protein
MAQGTVKWFNAEKGFGFIAPDGGAPDVFVHFSEIVGNGYRSLEDGQRVEFEITQGQKGPQASQVRAL
>NZ_CP017717.1|WP_080043976.1|9950447_9951245_-|Cof-type-HAD-IIB-family-hydrolase
MQSLPAPRLVATDLDGTALRTDGTVSPRTVAAFGKVEESGAVLAFVTGRPPRWMGGVAAAVRHRGLAICANGALIYDLHTERIVESHLITVEVLEEVVAQLRANVPELVFSVEYEAGFAHESDFLLGGLDRHQGAVRVDSVTARPCAKLLALHAAMGADELQAIVDELVGHLVTATHSSRRGLIEMSAQGVTKASALAAFAAQHGIKDTQTVAFGDMPNDLPMLSWAGTSYAVANAHPDVLAAVDHVTAANDDDGVARVLEELYG
>NZ_CP017717.1|WP_080043975.1|9949773_9950295_+|bacterial-proteasome-activator-family-protein
MNAEDNNTPHIVVVGPDFQGQGDNGEDDRSVTNLVEQPAKVMRIGSMIRQLLEEVRAAPLDEASRKRLKEIHESSIKELEDGLAPELVDELERLSLPFTDDNGTPPSEAELRIAHAQLVGWLEGLFHGIQTTLFAQQMAARAQLEQMRRALPGAPGVPGEEGGRPHGGSGPYL
>NZ_CP017717.1|WP_080043974.1|9948811_9949768_+|NAD(P)H-quinone-oxidoreductase
MRAIEIAGPGGPEVLEWREVPDPQVERGDVLIDVTASAVNRADVLQRQGFYDPPPGSPPYPGLEVSGVVAEVGADVEQFKPGDEVCALLGGGGYAERVAVPWQQVMPAPANVPLRAAAGLPEVACTVWSNVFMVGRLRRGETLLVHGGASGIGTFAVQLAKALGAHVVTTVGSAAKAEQVRELGADEVINYREEDFADKVRADVILDIMGAKYLTGNVRALRTGGRLVIIGLQGGRKGEIDLGAMLSKRLSVHATTLRARPVDEKGVIVRSVVDNVWPLVEAGAVKPVVYAEVPMAEAAEAHRMLDSGEHVGKILLVR
>NZ_CP017717.1|WP_155130041.1|9946420_9948172_-|AAA-family-ATPase
MQPPDWPRPGAEEPPAAPADEPARADESVRAEARAEVRAEEPPPAPEKAAWADTQPRNERPSWEEPATPAASAAPAAEEPVPAPAEPPRADLPQWAESQDKPALSWAEAPGGDVPQWAAESPETLPRADVPQWAAESPETLPRSDRPQWDEPEGRGQEQRLTWSEQQQDRSHWGERSSSDRAQEISDRAQETSGRIQETAGRSQETSDLRQQRADAPEQRQLRRQRTDQPEHRQRTDQPEWRPAEREIPPPPRRRPAPTPVFTSSPKPPLTGRPTAESLDPESLLRGRRNAPAKGWRRLVYKASGGWIKPGESPEVRRRRELVTRARTPVTAGHHRVAVLSLKGGVGKTTTTVGLGATLAQVRGDRVIAVDANPDRGTLSDKLVLETSATVRDLLNERDQVKRYVDIRAFTSQAPSRLEVLASDRDPSVSEAFSGSDYQAVSQVLENFYSICITDCGTGLLHSAMGGVLGLADQIVLVSSPSVDGARAASATLDWLEAHHYADLVKNATVVLCSVRPRSKSAVDIKKLEAHFAARCRAVIRVPYDPHLEEGAEIDLDRLQEPTRDAYLQLAACVGDGFAGIRE
>NZ_CP017717.1|WP_155130038.1|9946037_9946364_+|calmodulin-binding-protein
MTDITREQFVVQITDPDKIRHARELVSGETGERPHVVGRIAKQRTPYNARWSYHFRPETVDFFDVAIEVCDATIPYVEDHLDEAGGPFLPGLVFCPWTSRLVRELPAP
>NZ_CP017717.1|WP_080043973.1|9945294_9945657_-|STAS-domain-containing-protein
MAAVVTGVYVQEVADLNVEVQRGDSDALVRLTGDLDKLTAPLLKDALVRLFTEGRVAVVIDVAELDFCDSSGLWVLVEHQRRVSAHAGSLGIVNVHGVLQRVLDVTGLKAAFDRVVPAEL
>NZ_CP017717.1|WP_080043972.1|9944331_9945177_+|NUDIX-domain-containing-protein
MAAKDGDGWAECAQGHRHWGVHGASGLLVVHHDEAGVPYVLMQKRSWWSHHGGTWGLPGGARDSHEDAVTTALREAREEAALAGDGLRVQGVYLDDHGGWAFETVIAESAELLAAVPANRESTELRWLPLPEVAERKLHPGFAATWSDLQGAIRPETVVLDVANIVGARAEHGWWNDRLGAATRLLHDVSGLRLAHPVLAQWYPRMVAVVEGAARSAPAVQGVHVVAATGSGDDAIVDVVRQAKPWERVLVVTADRALKERVTGLGAETVGPKWLLSQLGG
>NZ_CP017717.1|WP_080047361.1|9955622_9956018_-|DUF4446-family-protein
MGVVAGISGVMIGYLALRQARATVEDCQRMLSRQISEGRGDLKAIRDVAVCRYDALSEMTGRLSFSVAMINGLGDGIVLTSINGRSETRTYVRGVVGGKGQQPLSPEEEEAVRAARLGHGPVVACRAAELL
>NZ_CP017717.1|WP_080043981.1|9956064_9957258_-|DUF2029-domain-containing-protein
MGVIRRQWWAWAVVVLVVAVAVAPLVDTWLTNPDDQRLVDLDVYRTGGQMLLDGRPVYDYVTPAPQLLPFTYPPIAAMLAVVLAWMSWETAQWVWTAGIFVALAVTVWLSFRQVLERESLRRYVPWAFALLMVLCTYLMPIRDQVRFGQVDILLVALCLADCVVRRPWWPRGFLIGLATAVKLTPGVFLIYLLVTRQWRTFFMASFAAAVLTLLPFAVIPQDAADFWFSALLDPERLGANAATTNQSIRGMLIRLYLPQEWLTLLVWAAIVVVVGWFGFRGAREAYRAGDTLTAVALVGLMAVLLSPVAWIHHLAWVVVVLAAIVGDGRDPVRLRVAAGVWLFYVVPVPWWGVSLISLKIPGVSLVLGKIVQNGFGLGAVALVWLLVSWLPKRRRIA
>NZ_CP017717.1|WP_080043983.1|9960356_9962318_-|DUF2029-domain-containing-protein
MDGGLSTGGRSQGSFWRGLSTGEGRSSVGVSRVCWNFPVTSQTHRIRARARPAGAATAAIGVSILLTITIGLLGPSAMVPALSGPAWHPPFSLGVEPDARLVIALAATAVVLGGLGLLLALREPGFGRLPKAQVFVLVGCVAAGVLAFLPPSGSGDHLNYAAYGRMVTLGLSPYTHGADDLPGDPIADAVERPWREEPSVYGPVATAVQALASWIGGDSLRLTMFVLAAVNAAAFIATALLIDRFTRDDPARRLRAALLWTANPLLLYQLVAGMHADTLAIACMVAALLARSRPMGAGALLGLGVAIKVNAGLVALGPAWELRRHPRRLALMAGCAVAVVVAGYAIVGPEAIAPMTRTSKSISHASPWKLVQGWIQVIVGPGSAYRGEIQIGSLLLLALIAWALLRLASLRGMLTPLRTPGNSDRPRTRGGALSEPGALGKPALSEPDELGKSDVLGRPEALGGPEVLDKPDALGGIPDTAGTAGTLGKLDAVGKPDMPDTAGVPGALGVAGSPRTLGMPGAGRTPDALGTGMGVGRGVEAPVVAAGLMVAYLFATPYILPWYDGLAFGLLALVAASALDTFMVAHLLVLSVAYLPARVDGVPAELDWLSKELRPQLAWVLLALTVALVVWAWRAARPVRRPRASAAPPPSAP
>NZ_CP017717.1|WP_080043984.1|9962352_9962892_-|DinB-family-protein
MPDIDEQGRPEPPLAEGELATLVGYLEYHRATLAWKTAGLDAAGLKATVGVSSMTLGGMLKHLAYVEDFWFARFLHDREGQPLWGTVDWKADPDWDWHSATGNTPEELRELWQDAVSRSRALLDEALADGGLDRLSTRAWGDGRKVNVRWILVHMIEEYARHNGHADLIRESVDGLTGE
>NZ_CP017717.1|WP_080043985.1|9962936_9963662_-|glycosyltransferase
MSGDTAVVIPAVNEADRIEATVKAAAALPGVDLVVVVDDGSTDQTGRVARAAGARVVRHSRNRGKAAAMETGAEAVRLLDEDAAPRHLLFLDADLGETAQAAAPLIAPVREGTADMTIAVFTTRVKLGGHGLVVRLSKEGIRRATGFDPAQPLNGQRCLTRAAFEAARPLAHGFGVETALTIDLLRKGYRVLEVEVDMAHRATGTDWRAQLHRARQLRDVARALAVREPVVVHNLDKLRHR
>NZ_CP017717.1|WP_080043986.1|9963695_9964043_-|STAS-domain-containing-protein
MELKVSTRSHAGCALVAITGEIDLYTAPHLQSEFTRLLQDGPSRVVIDMSAVDFCDSTGMNVLLSALKRMKEQGGALEVAAPRPAVRKILQVTGLDSVFTVHEEVPQELLVAEGS
>NZ_CP017717.1|WP_080043987.1|9964230_9964626_+|hypothetical-protein
MKAEKPEDAQRQGLRERLETIQISTEKATSWHDQAGRLRGLVNHEGYVPIRTRLAIEDLEFLAAARTELLRFSELGLRLLDLHQPRDAGGITSDTAHPILRCRSCMWRWPCPTFRAMAESFGEPRDLPESA
>NZ_CP017717.1|WP_080043988.1|9964643_9965750_-|two-component-sensor-histidine-kinase
MMPRPGDLPMIVAVTAGLGLLIALAGIWLMWRLRARSIGVMLAVVVVVAVTATLAGVVAIITKMFIEGPAKDFVLSVVAVGGLVGLGVAFVLARRVVGESRRLVQAVRAAPFVAPRGLPAELQTIANTLEEAYARERALEGARRELVAWVSHDLRTPLAGMRAMAEALEDGVVSDPATVARYHRQIKLEVERLSAMVDDLFELSRIHAGALRLSRARIGLADLLADTMAGAEPLARAKGVVLTAEASAAVPVEADAGALGRALGNLVVNAIRHTPSDRTVVLRAEVDAAGMACLSVTDCCGGIPEEDLPRVFEVAFRGEAARTPTADGGAGLGLAIAQGIVEAHDGVIDVVNDGPGCRFEIRLPLVGG
>NZ_CP017717.1|WP_080043989.1|9965813_9966506_-|response-regulator-transcription-factor
MNTRILVVDDDPTVSEVVARYLERDGHEVECVGDGAEALRRALARPPDLMVLDLMLPKIDGLQVCRKLRERWPVPVIMLTALGEEIDRVVGLETGADDYVVKPFSPRELALRVQSVLRRARGAAVTSGTGILRDGDLVVDVGAHEVRLRGEEVLLTAREFDLLAHLMRNPRQAFSRSALLNQVWGWSFGDSSTVTVHVRRLREKIETDPTDPRRIVTVWGVGYRYEPLEG
>NZ_CP017717.1|WP_155128785.1|9966600_9966774_+|hypothetical-protein
MGRVVMLVIGTLLGLFVLFNFLLPMLAGLIKLALIIGVIAVLVFVAVAVVGKSSRSH

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Crispr_ID: NZ_CP017717_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_30

10255588-10255691

Orphan

Consensus_repeat	Method
CCACGCCTTAGAGGCGGTCGCCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_30

>merge|NZ_CP017717|30|10255588-10255691|CRISPRCasFinder
CCACGCCTTAGAGGCGGTCGCCGGCTGGGAGTTGTCAGGCCACGCCGTAGAGGCGGTCGCCGGCTGGGGGGTTGTCAGACCACGCCGTAGAGGCGGTCGCCGGC

>NZ_CP017717|30|27|10255588-10255691|CRISPRCasFinder
CCACGCCTTAGAGGCGGTCGCCGGC	TGGGAGTTGTCAGGCCACGCCGTAGAGGCGGTCGCCGGCTGGGGGGTTGTCAGA
CCACGCCGTAGAGGCGGTCGCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080044207.1\|10251085_10251373_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367760
NZ_CP017717.1\|WP_155130050.1\|10247334_10248717_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080047392.1\|10250561_10251023_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP017717.1\|WP_155128861.1\|10261391_10261778_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044212.1\|10255205_10255430_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044210.1\|10252979_10254323_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP017717.1\|WP_080047391.1\|10248716_10249367_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_080047394.1\|10257557_10257995_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NZ_CP017717.1\|WP_080044211.1\|10254419_10254953_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|367615
NZ_CP017717.1\|WP_080044206.1\|10249481_10250579_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|236089
NZ_CP017717.1\|WP_080044214.1\|10257028_10257505_+\|tRNA-adenosine-deaminase-associated-protein	unknown	unknown	gnl\|CDD\|274869
NZ_CP017717.1\|WP_155128859.1\|10260627_10261248_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044208.1\|10251369_10252218_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NZ_CP017717.1\|WP_080044222.1\|10265224_10266658_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225822
NZ_CP017717.1\|WP_080044221.1\|10262416_10264936_+\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090
NZ_CP017717.1\|WP_080044209.1\|10252204_10252879_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP017717.1\|WP_080044215.1\|10258276_10258573_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|227737
NZ_CP017717.1\|WP_080044217.1\|10259599_10260565_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225203
NZ_CP017717.1\|WP_080047393.1\|10256500_10257010_+\|tRNA-adenosine-deaminase-associated-protein	unknown	unknown	gnl\|CDD\|274869
NZ_CP017717.1\|WP_080044216.1\|10258583_10259471_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225203

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080044207.1\|10251085_10251373_+\|hypothetical-protein	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	9.32812e-05
NZ_CP017717.1\|WP_155130050.1\|10247334_10248717_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.01399e-39
NZ_CP017717.1\|WP_080047392.1\|10250561_10251023_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.48196e-10
NZ_CP017717.1\|WP_080044215.1\|10258276_10258573_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	2.83856e-12
NZ_CP017717.1\|WP_080044210.1\|10252979_10254323_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	7.41132e-08
NZ_CP017717.1\|WP_080047391.1\|10248716_10249367_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.16059e-39
NZ_CP017717.1\|WP_080047394.1\|10257557_10257995_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	1.16356e-57
NZ_CP017717.1\|WP_080044211.1\|10254419_10254953_-\|PH-domain-containing-protein	gnl\|CDD\|367615	pfam03703, bPH_2, Bacterial PH domain. Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.	2.42568e-09
NZ_CP017717.1\|WP_080044206.1\|10249481_10250579_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|236089	PRK07761, PRK07761, DNA polymerase III subunit beta; Validated.	2.7964e-172
NZ_CP017717.1\|WP_080044214.1\|10257028_10257505_+\|tRNA-adenosine-deaminase-associated-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	3.36048e-35
NZ_CP017717.1\|WP_080044208.1\|10251369_10252218_+\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.58513e-78
NZ_CP017717.1\|WP_080044222.1\|10265224_10266658_-\|transcriptional-regulator	gnl\|CDD\|225822	COG3284, AcoR, Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription].	1.6905e-31
NZ_CP017717.1\|WP_080044221.1\|10262416_10264936_+\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP017717.1\|WP_080044209.1\|10252204_10252879_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	7.56005e-50
NZ_CP017717.1\|WP_080044217.1\|10259599_10260565_-\|hypothetical-protein	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	3.73533e-104
NZ_CP017717.1\|WP_080047393.1\|10256500_10257010_+\|tRNA-adenosine-deaminase-associated-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	5.56024e-49
NZ_CP017717.1\|WP_080044216.1\|10258583_10259471_-\|hypothetical-protein	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	4.85181e-89

>NZ_CP017717.1|WP_080044212.1|10255205_10255430_-|hypothetical-protein
MTDHTDTDPTPYADVETVLCDEFAGIHSATTVTRCVEAAHYGALEVTGYAHPSLVERIARKHLHVLALVASDRG
>NZ_CP017717.1|WP_080044211.1|10254419_10254953_-|PH-domain-containing-protein
MRLVTHGDSAPSSVNRYLLPHEQQVIMVRRHPAILLRPVAEVLGGLIIAGLLSKFFGGGEAGGTALVVVWWLWLLLLIRFVWKVAEWSVDYFVVTSKRMLLTTGLITRKVAMMPLGKVTDMSFQRSLLGRMLGYGEFILESAGQDQALSTVEYIPYPETLYLEVCQMLFPSKDDSDD
>NZ_CP017717.1|WP_080044210.1|10252979_10254323_-|helix-turn-helix-transcriptional-regulator
MPSQGTIGDRVRGLRLNRRMSQAQLAGPDLSDSYVSLIESGKRTPTPVVARLLAERLGCTTEFLLHGIEPRQRIDTELGLRHAELELQHGDPSIAADRFTEIVKAADEENAMLTAQARFGRARALEAQGRLGQAVEAFERLRREAAAHPERLADLPLTIALSRCYQRAGDRLRARDLAAAALTQAERLSITRGELATDLAAALIEARGESETDSRELAYVRQVLDLSGVPEVVDRSGEIQSLWHASAEAAAGEDSALAVRLADDAIGAGRQARLALQLARTAMHWSRMPSAPIEEAERFVASAVRAFAVFPGTVREHGESLVVHARVKLRAGDTVGAGELATSALGLAHDQSGTTAAEGHLVLATIALDGGLDASAHLRQAHELLVTLDRPVFGSDRQAARCWRELGDLYGRAGSATQQTAAYRKALEAAGVRSAMAGVTTDATVSR
>NZ_CP017717.1|WP_080044209.1|10252204_10252879_-|FadR-family-transcriptional-regulator
MSLRTAQRASLVDQVIDQLKEQITSGSWPMNGKIPTETVLAEQLGVGRNTVREAVRALTHAGLLECRQGDGTYVRATSELSGAMLRRLRQAEQLEILEVRRALEVESARLAATRRNDEDIRRIEAALAERERAWELDDPDFFVEADLAFHMAVAHATHNLVLIDLYEDFSAALRASITAAGTSLNKSYIPHDAIARAIAAGDAAAAERAGHACMEHILIALTES
>NZ_CP017717.1|WP_080044208.1|10251369_10252218_+|SDR-family-oxidoreductase
MTILITGAGGTVSRAVLRSLEGTADVRVLVRDPAKAPSGVEVAVGDLDEPATLGEAFRGVKTLWVLTPMGPHAPHRSMNALWAAKQAGVSHVVRMSAIGAAHDAPTRNGRLHALSDVELAASGLDWTILRPAFFMQNLFGSVNGDILYGALGEGRIGMIDVRDIGAAAAEILRAPERHKGATYTLTGPASISLASVAEDLSRVHGRPIGYERVPVEAAVRSMREAGLPAWDAQVTGEYLVAYAKGWGDYTTPDFETVTGRPATPFIDFARDHQALLGGVRTP
>NZ_CP017717.1|WP_080044207.1|10251085_10251373_+|hypothetical-protein
MTTTVELTRFRVSSDRADDLLAARPGMIADFRADRAGFLGAKLVRVSPDEWLDIVEWRSSADFAASRAKGANLPGIRAFFDLIDELVSAEEGTLS
>NZ_CP017717.1|WP_080047392.1|10250561_10251023_-|winged-helix-turn-helix-transcriptional-regulator
MRRSQRKQVEPDLGILSSRSLFNLQRELFTKLSEQGHPELRPRHGAVMAYLDEEGSRATDLAAQSGQHKQVIGTLVDELVALGYVERQPDPADRRAKLIVPTEKGRDHMVKSDAILAEMEAEHAKAVGEEAYAQFKRVFRLVVERQTGSGLAQ
>NZ_CP017717.1|WP_080044206.1|10249481_10250579_+|DNA-polymerase-III-subunit-beta
MKIRVNRDVLAEAVAWAARILPSRPVVPVLSGLLLEAGEELTVSAFDYDVSARAAIDADVAEEGRVLIPGRLLAEISRSLPADDVEIVTEGAEAVLTCGSAEFGLITMPVEDFPTLPTMPPSIGAIGGGVFASAVGQVAPAASRDDTLPMLTGIRVDIEGESVAMAATDRYRIAARDFAWRPAAPGVAVSAMVPARVLVEVAKSLRGGEVSIAMGDGVAGFESVGRSTTVRLLDEQFIDYRARLTSDWSIRADVAVAPFVGAIKRVALVAERNTAIRLSFSQGQVLIQAGGGDIGRGAEVVPCELRGDDIQIAFQSQFLLDGLTGIESDLARINMESPTRPALIQDVPGDAEPAFRYLVMSLRQT
>NZ_CP017717.1|WP_080047391.1|10248716_10249367_+|response-regulator-transcription-factor
MNRVLIAEDLYLLRDGLVHLLQAHGFTVVAAVESGPELLKGLLELRPDVSIVDVRLPPTFTDEGLQAALAARKQIPGLPVLVLSQHVEQLYARELLADGSGGIGYLLKDRVFNAEQFVDAVRRVAEGGTAMDPEVIAKLLARNARNEPLAALTPREREVLEAMAEGRSNAAISQRLFLSESAVAKHTASIFAKLGLAPSDDDNRRVLAVLAYLDSR
>NZ_CP017717.1|WP_155130050.1|10247334_10248717_+|sensor-histidine-kinase
MTALLVLGVVQAVVLALSVPMLLLAFMLGVVLLFPWQVRMVRRLAELNRRLVREWTGLEVESPYLPAPPPPVPEPNGMYRSERTLYKTPRVPAWNNRWKWMVKDPATWRDDLWLLLDPMVKVSLLPVFAVIPERALLMYAHWTDLLLGATVASRLAGQVSHLRRTRNLATDSQAAEMRRIERDLHDGTQARLVAIGMTLGAVEQLVDTDPQAAKALLTKARESSAETLTELRRVIRGIHPPVLAERGLADAVRALAMDSPLQVTVTVDLPERPESPVEAAVYFAVSELLSNAARHGDASTAAVDISSHGADLRVTVTDDGLGGADPAKGSGLNGIERRLLAFDGVLALNSPPGGPTTVTLDLPGVLPHEPADKLPRGKAIAIALLWCTAWCPSFPQGVVPAIFKIFGVEEKSWFLALHVPEPWQWPVIFAMIAVGGTMYVMAHHLRANHESRHLPTKLGC
>NZ_CP017717.1|WP_080047393.1|10256500_10257010_+|tRNA-adenosine-deaminase-associated-protein
MTDEDALDFAIVVYREDGCWQAELLPATLTSDLQGLIHALKQQPSESGTIGLVAVGDEFFVALRVLGDRVDVFLSDIAASWDFPLAEQVLEYLDVPVPDEEELDEILQDEETVLPAGDLSIFADLGLDEMELGILSGDIDLLPEDVLSSIAARLGFSEPFERAIESVFG
>NZ_CP017717.1|WP_080044214.1|10257028_10257505_+|tRNA-adenosine-deaminase-associated-protein
MASNTFSAAFVRTSDGWSGAEVDLGDAEIVDDFGDAVMEALGLTGDELALLCVEVEDEWFAIARYRGEDEPRVFLSDVHAVLADHLGELFAEFAGVAPDKDANGLGVRPAGDFELLSDLGVSSEELLELSMEEGMLPADILSVIAERLSFADELDRLR
>NZ_CP017717.1|WP_080047394.1|10257557_10257995_+|nucleoside-deaminase
MRLALAEAVAAGEREEIPVGAVVLDARGEVLSAAGNDRESAADPTAHAEVLALRRAAARRGEWRLSGCTLVVTLEPCTMCAGAAVLARVERIVYGATDEKGGAVGSLWDVVRDRRLNHRPEVVMGVMAEECGSVLTRFFATRRIR
>NZ_CP017717.1|WP_080044215.1|10258276_10258573_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MIFKLVGDGRPYPDHGLTNREWAQIPPRQVRLDSLITTKAMLDLHSLLAADSTFYGDLFPHVVQWQGELYLEDGLHRALRAALHQRSILHARVLDLPN
>NZ_CP017717.1|WP_080044216.1|10258583_10259471_-|hypothetical-protein
MDFKDQVDLDASQVEDRGSGGGGGSGFSGFPGGMIVGGGGIVSLIVLVLVFVLNNVGGGGGSGEPARLQPSSNLSEQCKTGKDADQSQKCQVVGVVNSIQGYWKQEMSGYRPAKTILYEGRSSTGCGAASSEVGPFYCPRDQHVYLDLSFFDQLHSQFGAKGGPFAQAYVIAHEYGHHVQDLLGVLDSGSSVPIELQADCYAGVWARNALDTGFYEKPFTPAEISEALDAAAAVGDDRIQQRTTGRIDPESFTHGSSQQRVNAFQRGYEKGEPADCDLSGLALSRTDSARNPKLS
>NZ_CP017717.1|WP_080044217.1|10259599_10260565_-|hypothetical-protein
MQFDDDKPLDPSQVEDVRASGPRPGGGGFGGGGFGGMPGGCVLPVGGRGGCLLLLLAVGAMFLFGIVPTPFTGDEGGQQGGGRQPSAPPAASPSGNLAERCRTGADADQSEDCRVVGTVNSIQAYWRQAFQERGRKEYTPAKTVLFSQAVETGCGAADSAVGPFYCPADRKVYLDLTFFDTLQRDFGAEGGPFAQAYVIAHEYGHHVQNLLGTMNRVGRGNRPGADSPSVRLELQADCYAGVWAQNAVKTGFYREPFSQDDINQALSAAAAVGDDSIQRRTQGRVTPDAFTHGTSRQREKWFSTGYESGDPLRCDTFTGGI
>NZ_CP017717.1|WP_155128859.1|10260627_10261248_-|hypothetical-protein
MATSGRRRAVWVGLALAVALVAVAMPDRWPRPRVVGAAGEEVLRVGSATRAALLDAADRHLETDPARIGHYLLTAERPELRPRVFCREEFVEVRRKGSYLLLGVVAACEELARSGTRLLGGTGFRSALLLTVGRDDGGRFTVREVEEPLDGDGNLPSIRAMFSPEGAQRAVELQEDGAGAHRAIAGEACRVFGLPAGTAVTYDMGS
>NZ_CP017717.1|WP_155128861.1|10261391_10261778_-|hypothetical-protein
MIKVDPGAVAEARSVGRVVTETFTDPFYERTVQVIEILVIDMRAAGFPEALDLARDRLERLGWYEVGSTDVSVQMESSRWKGTTTTLGSVEDLDPLGAQLEPAADEALQAEPKRWATYVVVSLSSVGE
>NZ_CP017717.1|WP_080044221.1|10262416_10264936_+|DNA-polymerase-III-subunit-gamma-and-tau
MSLALYRKYRPGTFAEVKGQEHVTDPLRQALRTGRINHAYLFSGPRGCGKTSSARILARSLNCEQGPTPDPCGACESCVALAPTGPGHLDVIEIDAASHGGVDDARDLRERAFFAPVSARYKIYIIDEAHMVTREGFNALLKLVEEPPPHLKFIFATTEPEKVIGTIKSRTHHYPFRLMPPATLKALLEEILTSESVPFEPAALPLVVRAGAGSARDSLSILDQLLAGADDDGITYAKAVSLLGYTDGDLLDEVVNAFAARDGAQVFHTVNRVIEGGHDPRRFASDLLERFRDLVILANVPEAATSGLLDRPADELERLVQQAASMGPAELTRAAEVFNAGLTEMRGATSPRLLLELMCARVLLPGAAQGEAALLARLERLERGGAVAQMAARAGVPGGAGGGVPGGSGGGSHAGVAAGVPGAAGVPVASAGGAPAGSLGTVSAAGGAQGGAMAASGAGPVRVAADGDVPGVSAAPGVSAASGAQADSAAPGAQAHAASGGDDWPEPVRPGAAAAAPAPVQAAPAGGSYQAPQAPAGAPAAGGAGVVQSQWAAVLAALKQRSIVVWANVSTNAQVVGVEGNLVTLGFSQVGAMKNFTGGGKDAVVASVLGEVLGGTWRVEAVVGGTPAPRSPARPPSHGGAAAPGAAAPGGGGHGPGGAPTAPGPQGVSGPQVVAQGVPGPQGGQGAGGSQGRTASHGASHQDQGQDSDQPPAGAPGRQTTDESWPDAPDDFAPGAPPSPDPTQTVSAVAAAGGVQTGAGLAAARSAAKAAAQSGPRVATATRGAAPAWPDAIPGRDKGPESDEVDPLNDADADVDAVSGMALLERELGAKVIGEIDHT
>NZ_CP017717.1|WP_080044222.1|10265224_10266658_-|transcriptional-regulator
MSYAHLNAYSRLLRGAHEAVATGRAWPESPRRLIKASWRRSLDAGIDPEGTSAPLVCDPTSMRDIRDTHPLQPLLPLLAQTLSGMADETGHIMIVTDGDGRVLWREGNRTVMRHADRIGLADGHQWGEHDVGTNGIGTALATGRPVHVYSEEHLMRVLHIWSCSAAPITDPDSGRVIGCVDVSGTARSLHPATVALVAATAKLAETQLALRMHERDERLRRRYESLRGRPGILLSATGRVISGDPAGDLGERVHVGERLSPGHRLLLRDGTVAHLEPFSGGYLLHPAPSAAPQPLTLSLLGEGIPTASYGDGDRPLSLRHAELLALLTLHPHGLTAEQLSFHLYGDAGNPVTIRAEIHRLRAQLGEAIAAKPYRLACPVEADFLKVRHLLSSDDPAALARAYPGPLLPRSESPEIRRERDELEAQVRAFLLRRGGPDEWWVYAQTCNGRDDYEVLERLAALPPTDLRSAAARSRLLS

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Crispr_ID: NZ_CP017717_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_31

10336375-10336466

Orphan

Consensus_repeat	Method
GCGCTGCCGGCCGCGCACCCGTGACGGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_31

>merge|NZ_CP017717|31|10336375-10336466|CRISPRCasFinder
GCGCTGCCGGCCGCGCACCCGTGACGGCCGCCCCCACGACGGGCTCGGATCATCCGCGATGCGCTGCCGGCCGGGCACCCGTGACGGCCGCC

>NZ_CP017717|31|28|10336375-10336466|CRISPRCasFinder
GCGCTGCCGGCCGCGCACCCGTGACGGCCGCC	CCCACGACGGGCTCGGATCATCCGCGAT
GCGCTGCCGGCCGGGCACCCGTGACGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_155128866.1\|10338949_10340170_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044287.1\|10342548_10343709_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044281.1\|10332656_10333016_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225065
NZ_CP017717.1\|WP_080044292.1\|10348374_10349541_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173848
NZ_CP017717.1\|WP_080044275.1\|10325858_10326521_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_155130059.1\|10343705_10344278_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP017717.1\|WP_080044285.1\|10337885_10338872_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP017717.1\|WP_155130056.1\|10327939_10328266_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047402.1\|10340373_10342533_+\|polysaccharide-lyase-8-family-protein	unknown	unknown	gnl\|CDD\|238517
NZ_CP017717.1\|WP_080044282.1\|10333195_10333663_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP017717.1\|WP_080044276.1\|10326517_10327672_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP017717.1\|WP_080044274.1\|10325213_10325813_-\|sulfite-oxidase-like-oxidoreductase	unknown	unknown	gnl\|CDD\|239027
NZ_CP017717.1\|WP_080044289.1\|10344277_10346410_-\|peptidase-domain-containing-ABC-transporter	unknown	unknown	gnl\|CDD\|225183
NZ_CP017717.1\|WP_080044291.1\|10347507_10348293_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017717.1\|WP_080044279.1\|10329768_10330239_-\|cytoplasmic-protein	unknown	unknown	gnl\|CDD\|130425
NZ_CP017717.1\|WP_080044278.1\|10328262_10329765_+\|multicopper-oxidase-family-protein	unknown	unknown	gnl\|CDD\|225043
NZ_CP017717.1\|WP_080044283.1\|10333731_10335156_+\|WGR-domain-containing-protein	unknown	unknown	gnl\|CDD\|368427
NZ_CP017717.1\|WP_155128868.1\|10346453_10346627_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044290.1\|10346691_10347507_+\|patatin	unknown	unknown	gnl\|CDD\|224666
NZ_CP017717.1\|WP_080044280.1\|10330313_10332602_+\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|376913

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080044291.1\|10347507_10348293_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.74257e-11
NZ_CP017717.1\|WP_080044281.1\|10332656_10333016_+\|hypothetical-protein	gnl\|CDD\|225065	COG2154, COG2154, Pterin-4a-carbinolamine dehydratase [Coenzyme metabolism].	4.26486e-05
NZ_CP017717.1\|WP_080044292.1\|10348374_10349541_-\|hypothetical-protein	gnl\|CDD\|173848	cd01159, NcnH, Naphthocyclinone hydroxylase. Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.	7.15568e-56
NZ_CP017717.1\|WP_080044275.1\|10325858_10326521_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.13767e-64
NZ_CP017717.1\|WP_155130059.1\|10343705_10344278_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	9.17671e-21
NZ_CP017717.1\|WP_080044285.1\|10337885_10338872_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	7.6488e-14
NZ_CP017717.1\|WP_080044290.1\|10346691_10347507_+\|patatin	gnl\|CDD\|224666	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only].	2.05705e-23
NZ_CP017717.1\|WP_080047402.1\|10340373_10342533_+\|polysaccharide-lyase-8-family-protein	gnl\|CDD\|238517	cd01083, GAG_Lyase, Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.	0
NZ_CP017717.1\|WP_080044282.1\|10333195_10333663_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.82613e-11
NZ_CP017717.1\|WP_080044276.1\|10326517_10327672_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.34131e-41
NZ_CP017717.1\|WP_080044274.1\|10325213_10325813_-\|sulfite-oxidase-like-oxidoreductase	gnl\|CDD\|239027	cd02109, arch_bact_SO_family_Moco, bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	1.33441e-89
NZ_CP017717.1\|WP_080044289.1\|10344277_10346410_-\|peptidase-domain-containing-ABC-transporter	gnl\|CDD\|225183	COG2274, SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms].	0
NZ_CP017717.1\|WP_080044279.1\|10329768_10330239_-\|cytoplasmic-protein	gnl\|CDD\|130425	TIGR01358, Phospho-2-dehydro-3-deoxyheptonate_aldolase, 3-deoxy-7-phosphoheptulonate synthase, class II. This model represents the class II family of 3-deoxy-7-phosphoheptulonate synthase, aka phospho-2-dehydro-3-deoxyheptonate aldolase, as found in plants and some bacteria. It shows some similarity to the class I family found in many bacteria. The enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids. Homologs scoring between trusted and noise cutoff include proteins involved in antibiotic biosynthesis; one example is active as this enzyme, while another acts on an amino analog. [Amino acid biosynthesis, Aromatic amino acid family].	0.00734803
NZ_CP017717.1\|WP_080044278.1\|10328262_10329765_+\|multicopper-oxidase-family-protein	gnl\|CDD\|225043	COG2132, SufI, Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism].	1.23731e-91
NZ_CP017717.1\|WP_080044283.1\|10333731_10335156_+\|WGR-domain-containing-protein	gnl\|CDD\|368427	pfam05406, WGR, WGR domain. This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Rhizobium radiobacter Ych and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain.	1.22441e-19
NZ_CP017717.1\|WP_080044280.1\|10330313_10332602_+\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	0

>NZ_CP017717.1|WP_080044283.1|10333731_10335156_+|WGR-domain-containing-protein
MTYLELSEDGGGSHKFYEVIVAGTDVTITYGRIGETGQTKVTSFPTEAKAQAAAAKKLAEKTRKGYAPAVRGVRQRRAVTRRAITSTRSTAQQAPVLWRFDSGASAFGIFVDGERCWVGNQRGDVYTVTHSGTVTGRFRLPDGVKCIVADDFWIYAGCDDGRVYDLSGKVPRSAYEIAADVDIYWLDIHDGVLGVSDRAGRVTAIDYEDEFQWARTSGGDSAWMVRCDADSVYFGHSRGVARYDISDGTPVWETDVADQVLFGWQEEHSVYAGTGRRTVHRLAKGDGRVEAVYQCDGAVYSCATSPGGRHVFAGDNHSSVYCFDASGERLWKLATGCGSAFSMQYLDDRLYIVTTDGTLACIDASEAAIAAARTGSVPQPVDVKAAASLEAVEPSAVLETVTATAGDAGDGVVVECVREGERLRVRVISPGYESWNVQFPKDIREPGARYLVDGVRSAGRGGFYRAYGEIRRLL
>NZ_CP017717.1|WP_080044282.1|10333195_10333663_+|ATP-binding-protein
MTRLRSTRRSRKQYAWPLREDARTVGQARALIRMELSELSLSSDLVDDAVLMVSELITNAFMYGDAPYELILHVDEKDIMFVVVDGSPVLPAQAPHDLGAEHGRGLRIVARLSDGFYGCHPQRYVTQPDLVGKATWFALPRAGTAPNVVPIRAGF
>NZ_CP017717.1|WP_080044281.1|10332656_10333016_+|hypothetical-protein
MRHRELLRRPGSGGGVTGPKGRGAPLTDDEVAAALRALPRWSGDRSGLRRTLLLPQENLLAIRRALDQLKITYGRQPQLHDTPDGLTLLVRTVAVSAVTSLDLELARRVDELIDEIGRS
>NZ_CP017717.1|WP_080044280.1|10330313_10332602_+|xanthine-dehydrogenase-family-protein
MGDPYVGARTPRREDARLLTGKARYVGNVRLPGSLHACVVRSPIAHGRLLGCDAKAVWAVEGVTDVITTADAAHLRLPCVNVLPGQRITSYPVLDDTIRYAGQPLALVVARTPEAARDAADLLDLDLDELPATVGAERALDAPPLYPELGTNVITDFAMGDEDCGAAIDGAEHVVELVCRMGRVSPYPLEPRGVVAAYADDELIVHISSQAPHHVREHLAEAFGLPHDRIRVISRDIGGGFGAKEHVYPDETLVCLAAMRAGRPVSWTESPGDRLTATMSARQAVHRARLALDGDGRFVAMDVDVLGDLGAHPGNTGASTFAVTATLLPGPYRFGRFAVRVRGVVTTTAPAGSYRGFGQPEATLTRERLIDEAARRLGIDRVELRLRNMLRPEELPCTTAVGQTYDSGDYPRALRTLRDLVQEAGVERRGDDGRRRGVGYSCHVETTGLGPSMDLKAMGAAAGGYESVVLRMEQDGSVVVSAGVVSIGQGIETALAQLAADRIGVPIERVRVLLGDTATTPYSSIGSIASRSLPVGGGALTKAALKLRDKLLAIAAHRLEAAAADLEVAGDAVRVKGDPAVSVPLRELATSAWRGWDLPDGVAPGLEERDSYDPTGYTFAYGAHAAAVAVDPETGAVEVEGYWVVNDAGVLVNPAVVEGQIMGGVAQGIGEALTEEIVFTDDGQPITDYLPPTTREVPDIRVVMLETPSPVTPGGMKGVGEAGTIGPPAAIANAVAAALPEIADRVTDVPLTPGRVWSLLQA
>NZ_CP017717.1|WP_080044279.1|10329768_10330239_-|cytoplasmic-protein
MQTFLPYPDFTASAAVLDPLRLGKQRVEALQVLRALTVPGYGWRHHPAVKMWTGYEEALVRYGLEVCGHWCSMGRADTCAGTMTTELAQLRGAPGIRTQAELGAARELPPWLGDERLHLSHRSALLRKDPGFYRPIFGDEPDDLDYVWPRSDRLPA
>NZ_CP017717.1|WP_080044278.1|10328262_10329765_+|multicopper-oxidase-family-protein
MSPTGRGRATARAGLGPTRRDVLRLLGLGAVAVAGAQGCSLLTGTPQPQLLAGAAALPRPYTVPLPIPEVAKPVRSTGEADFYELTERAAEAELLPGLRTPNWGYGGTFPGPTIRARSGRRTVVKLINQLGEPTVLHLHGGHTPPESDGYPTDLVAPGASREYVFPLEQRAATLWYHDHRMDYTGPQVWRGLAGMFLVGDAEEEALPLPRGERDVPLLICDRSFAADGTLLYPALEGRPGVREAYMGGVLGDVILVNGAPWPELRVERARYRLRLCNASNARAYELSTGGPMVQIGSDGGLLAAPRTVRQLRLAPGERADVVVDFSAYGVGQHVELRNLAGEGPQARVMRFAVERDAKDDSSVPARLSTVEALDPARATVTRDFEFSSGSMHGGTGWLINGRPFDAKRMEARPKLGDVEIWRLTSDVAHPVHLHLDQFQVLSVNGERPKGPPEWKDTVELRDAQTVEIVTRFTDYRGRYVLHCHNLEHEDMAMMAAFEVV
>NZ_CP017717.1|WP_155130056.1|10327939_10328266_+|hypothetical-protein
MHVVALLFQAVTAGMLLSTPGGRALHGASAMALAVIGLLHLVAAILVWRPGGGPATFIGPAAGLLLFTFVAAALGIAHVKVVHLPLGVMLFGGGVAQLIRVMARPGRA
>NZ_CP017717.1|WP_080044276.1|10326517_10327672_-|sensor-histidine-kinase
MSSARGWRSLAQDGALAAVVAALLTLTVLATPAAGALDLAAVLIAAASLVAWRRAPLVALAISTVCMLVYATHAQPGPPAAFPVLVSVYGAVRAGHRLLPALAGVLFLGAGLAVSLASAGPGEERLVVQNTTLLLGWFLAAGVTGTVSLHRQAYVQQAEQRAAEAERTREEVARRRAGEERLRIARELHDSLTHSISVIKVQAGVAVHLARKRGEEVPAALLAIQEASGDAMRELRTTLELLRDPDPDEADEPDGPSGLDRLGDLVERARAAGLPATVTVSGERRGLPPEVDRAAYRIVQEALTNVSRHAGAAAAAVRVDYGGRELVVQVDDDGKATRDAPPVAGVGLRGMRERVTALGGRLLAEPRAEGGFTVRAELPLGDLT
>NZ_CP017717.1|WP_080044275.1|10325858_10326521_-|response-regulator-transcription-factor
MIRVLLVDDQALIRGGFRALLEAEDDIEVVAEAANGEQAVALALEHLPDVALVDVQMPVMDGIEATRRIAADERLRGVHVVILTNYGLDEYVFDALRAGAGGFLVKDTEPADLLQGVRVAARGDALLSPAITRRLIGEYVARRPEPHPEGLDALTNREREVTALVARGLSNDEIAAHMVISPMTAKTHVSRAMTKLRARDRAQLVVFAYESGLVVPRAGR
>NZ_CP017717.1|WP_080044274.1|10325213_10325813_-|sulfite-oxidase-like-oxidoreductase
MSIISRGFRGKRRDDSGRVPPGQYLVDDFPVLSAGPTPRVPLDRWEFAIDTEAEQTHRWSWEEFMALPAETPTVDIHCVTKWSKLDTTWEGVSLDVLFEDVETAAEYALVHSYGGYTTNLPLEDLLDGKAWIVHRFDGEELAPQHGGPARLIVPHLYFWKSAKWVRGIRLLNEDWPGFWETAGYHNYGDPWREQRYEGD
>NZ_CP017717.1|WP_080044285.1|10337885_10338872_+|AsnC-family-transcriptional-regulator
MVVEIIELDEVDRGLLHALQVDGRASFSRIAEVLGVSDQRVARRYRRLRSTGMLRVVGVVDGRRLGYESWAIRLRCTPDAAVAIAEALGRRSDTFWVHLLSGGTEISCGTLQRTAAERESLLLGKLARTNRVLSMTAHRTLYTFVGGRVGWQGLAALSPEQVAHLEEGRVYRRRGEGEPIVLGPGDQALLDALSRDGRTAHADLAAVTGWSESTVRRRMDQLCAAGALFFDMDVLPALLNYQVEAQLWMSVPPAEIDATGRALAGHHEVAFAGATTGPTNLTASIVCRDDEAFYRYVTDSLGALPAIRHIETAPIIRTIKRAGAVLPL
>NZ_CP017717.1|WP_155128866.1|10338949_10340170_+|hypothetical-protein
MRTPMRTRLLALACAGLVLATATAPAALAAAAPARETVTIDNRGSIVTAELLARMTAEQVAAYLTKAGFPVPARPQGADLYAVVYRTIGVTGTPTTASGVVALPARSRKGLWTVSYAHGTLATRADAGSVDDGDGRVIPLMFAAAGFAGVAPDYLGLGKGPGFHPYMDAASEASASADLLRAAGELAGQQGRALSGDVLVTGFSQGGHAAMALGKALRADGAYRLRGAAPVSGPYHVRSAEIPALLDGRLDPHSATFYLAYWTVSMNRLHHFYDTPAEVFRDPAVEKLFDGDHSFEEIAAGLPASPRDLVTAAYLERIAKPSGAVLRAMRVNDTTCAGWRAGVPVRLFAARGDKDVAYDNARHCLRDLKVSGVKASLKDVGDVDHMTSAFRSMPEVLDWFVTLRRG
>NZ_CP017717.1|WP_080047402.1|10340373_10342533_+|polysaccharide-lyase-8-family-protein
MGALAPAAAAHTPDDTFVRLRRRWREVTAGPGHDSEGYHARLAALARAAGRYRATMAPGPSSLWPDQPFPSFVATPRRLRVMAQAYALGLGDATLAEAVAEGVEHYRRHVYAAGGDAPGNWWHWQIGVPKALLDASVLTGTGSAALAEAVDHYVPERRLRRYEGNSTAANRVDLCVVTLLRAMLDDDHARARLAVSALSPVFATVSEGDGFYRDGSFIQHSYVPYQGAYGVTLLSGLATLYAVLRGSPWELADQRIFDTVERSFAPFVHDGACMDLVRGRSVGRRPFGDHERGREIAAAVLLLGESAPAGTRARWRAMVKGWAERGTSRPMLEHAAEPAFHARLAALLADGAVPAAAEPVGHRLLPMSARAVHRRPGWCAALSMASHRIGHYEHGNGENLRGWHTGSGMLYWWAGGHGDQYSDAFWPTVDPYRLPGTTVSTRRLPDGAGAAWGDTRTPWRWVGGATDGTYAAVGQHLSGLESTLEAFKSWFFLDDLIVCLGAGITCADGVPVETVVDNRRTAARLDTGDGWAHLEGHGGYVLPGQPLRTLRERRTGGGVSRDYVTLWLDHGVDPRAASYAYLLLPGASKQDTRARAAALTTPGPDGAPVRVLANTAGLQAVHVPALGLTAACFWSAGTAGGLTASAPCAALVRERPDGTATVTVADPRCDLDELTLTWAMPVAELLDGDALLSGGRLTFERPADREGASLTVTVRLGRG
>NZ_CP017717.1|WP_080044287.1|10342548_10343709_-|hypothetical-protein
MTDRTFARLKPEGLDELAEDGYRRRRSGDLARAFATPRTEAAPLRRRRPYVLAAATLAAGLAAVAASVVVTGDPAPRPAPPSASSAAPTVVDARSFLLAAATTAKREPAESGRYWYLNERTLQKVHVAPGEYMAGLKELSARFEKKEKELKGDQERLEAAREEFEREVGELKRQELPYTAFAADTTESWRAMRPGETSRSVRGQDVKVTFGSAEDEAAWRAAGSPELVQPGAGPRDDATPRVLSIDNPSLTLQNVRELPTSKDELRRRLDELWKRSPNSADVGKAGYLWQTGVDLMTAPIRPGTRSALYQVLADQPGIASKGEVKDALGRTGVALSVSTADGADFRLVFDPGTAELLEYDVVDKGVTQLRVAVAGMGFTDKLGERP
>NZ_CP017717.1|WP_155130059.1|10343705_10344278_-|sigma-70-family-RNA-polymerase-sigma-factor
MSARSEGLLGVDDPEERFTDLYDRHYRSVLGYALLRADRDVAEDVSSETFLVAWRRLAELPEPPLPWLLGVARNLLAKQRDSRHRRQALVDRITALTTSRDHEAWDVAEHVVDRETALAALSALPERDVEAMVFATWYGLPPEQAAGVMGCSVRTYNVRLHRARKRLARALGLDGGRHPRVLNTPLEDPR
>NZ_CP017717.1|WP_080044289.1|10344277_10346410_-|peptidase-domain-containing-ABC-transporter
MRRRVPVVLQNTDTECGAACLTMVLAHHGHRTTLHQVADRLRIGRDGLSAKAVVDGAREHGLQARAFSLAPEDLARVPLPAVAHWEFGHFVVVERWSPDRVDIVDPAQGRRTLTPQEFGAGFTGVLLVFQPGEGFRRGSSSMAGAWRREFARTLLRRRRGLLAQIVAASLLLQLLGLALPLFSGLLVDTIVPARAAQALPLLGVAVALAGAAQFVIGYLRAALLVAVRARADQELTESVVGHLVALPYRYFTSRAKGDLVTRAAGVSTLGDLLTGQIVAALLDGPLAVGYLVLVYFWDPVFGLALTGVAALQAVLLLATTSRIAALDRQELTALSASQSSLIQTITGIETLKATGAERRAVEQWSGHFARQLDADVRAGLTRGLLEAALSAIRVTAPLGLLWLGAWRVLDGRLTLGTLIALNAIALGALTPLGSLMTGLQNLQQAGAHFDRLSDILASEPEPSDGIEVLRLRGAVEVRGVSFRHDPRGAWTVRDVSLAVRPGQKVALVGASGSGKSTLARLLLALHDPVEGEIRYDGVPATELNLRTLRRQFGVVTQEPSLFSGSIRENIALNDPGASLARVVAAARLAALHDEIAAMPMGYETMLTDGGGLSGGQRQRLALARAVLPRPKILLLDEATSNLDSATEAVIEANLGTLAQTRIVIAHRLSTIRDADVILVIDGGRVVQRGTHDELIASGGKYAQLVAAQTR
>NZ_CP017717.1|WP_155128868.1|10346453_10346627_-|hypothetical-protein
MRLIYREEALRERERGRASARRPAVARGPSFLVLWIAAAIVVTAGIGVTALALGTLR
>NZ_CP017717.1|WP_080044290.1|10346691_10347507_+|patatin
MRRALVLGGGGVAGIAWETGVLAALADEGVDVTAADRIIGTSAGSTVAAQVTSGLPLKELLARQTDPALQTPELVSGVSLPELWVKLQAIAESGLDPAAQRREIGALALAAATVPEAERRAVIEARLPVHEWPDRDLVIVAVEAVSGEVRLFERGSGVGLVDAVAASCAVPGVWPCVTIDGVRYMDGGVRTSTNADLAAGFDRVLVLAPMAEVGEPAWTRLDGTVEVIEPDEATLAAFGTDPLAPESRTPSAEAGYAQGRAAAARVAAMWR
>NZ_CP017717.1|WP_080044291.1|10347507_10348293_-|alpha/beta-hydrolase
MTTTVHILERPDVRLRYEVRGSGPLLVLTGAPMAAAEFAPLAEALAGDRTVVTHDPRGISGSVLADPAQDSTPELRAGDLAAILDDLGADSADVFGSSGGAVTGLALVARHPGRVRTLVAHEPPCVELLPDAAEQRAAVDDMIETFHRDGLWAAFAKFMGNAGFEEGEEAGPPPSEQVVADGSRFFAHELRGTTRYVPDVEALKAGRVVVGVGAESAQLVTYRTSVALAGLIGVTPVEFPGDHGGFVAHPEKFAEVLHGLL
>NZ_CP017717.1|WP_080044292.1|10348374_10349541_-|hypothetical-protein
MSDTPRLHRAGTTLLERARDLRPLIEREAERAETDGKLTAPVVDALHDAGLFGSWVPAPLGGAELSPAELLAIFETLTYADPSTGWVVMATCLENGTAGAYLGEDAVERIFKGPRMPLIAGQGTRTGVAVPENGGHRLTGQWSFASGMYHAQYAHSAAVVEGTDEVRIFITPIEDVKMLGNWDVLGLRATGSIDYSIDGVFVPESQSHAFALDEPLRGGAIYRLGLLDQALICHSGWALGIGRRLLDELAGYAAARSGRPGQLAGSDAFHTGFARAEAKFRAASALIRETWDGVERTLDDGGRLSVRQETMVRLALNHITATVTEVAAFVYASGGTTALRDGLIQRLFRDAQAGAAHILSGPQALRECGRELAGLAQGERWVVLGLEG

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Crispr_ID: NZ_CP017717_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_32

10459164-10459252

Orphan

Consensus_repeat	Method
CCGAGGCCGAGGAGACGCTGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_32

>merge|NZ_CP017717|32|10459164-10459252|CRISPRCasFinder
CCGAGGCCGAGGAGACGCTGCAGGCGGCCAGGGCCGAGGCCGAGCGCACGGTCACCATGGCCAGGGCCGAGGCCGAGCAGACGCTGCAG

>NZ_CP017717|32|29|10459164-10459252|CRISPRCasFinder
CCGAGGCCGAGGAGACGCTGCAG	GCGGCCAGGGCCGAGGCCGAGCGCACGGTCACCATGGCCAGGG
CCGAGGCCGAGCAGACGCTGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_155128886.1\|10457115_10458018_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044383.1\|10461351_10461906_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP017717.1\|WP_080044388.1\|10465956_10466925_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NZ_CP017717.1\|WP_080044375.1\|10453869_10454937_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340847
NZ_CP017717.1\|WP_080044372.1\|10450039_10450624_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NZ_CP017717.1\|WP_080044381.1\|10460091_10460334_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044371.1\|10448369_10449179_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP017717.1\|WP_080047417.1\|10461962_10462667_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP017717.1\|WP_080044386.1\|10465006_10465444_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NZ_CP017717.1\|WP_080044377.1\|10455745_10457062_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044385.1\|10464212_10465010_+\|2-keto-4-pentenoate-hydratase	unknown	unknown	gnl\|CDD\|183092
NZ_CP017717.1\|WP_080044376.1\|10454966_10455248_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835
NZ_CP017717.1\|WP_080044373.1\|10450763_10452890_+\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NZ_CP017717.1\|WP_080047416.1\|10449190_10449949_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP017717.1\|WP_080044374.1\|10453069_10453873_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044389.1\|10466938_10468054_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380667
NZ_CP017717.1\|WP_080044382.1\|10460457_10461210_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP017717.1\|WP_080044384.1\|10462684_10464220_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|132260
NZ_CP017717.1\|WP_080044387.1\|10465440_10465956_+\|3-hydroxyanthranilate-3,4-dioxygenase	unknown	unknown	gnl\|CDD\|183930
NZ_CP017717.1\|WP_080044379.1\|10457989_10458520_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080044383.1\|10461351_10461906_-\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	3.34911e-19
NZ_CP017717.1\|WP_080044375.1\|10453869_10454937_+\|glycosyltransferase	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	9.69535e-79
NZ_CP017717.1\|WP_080044372.1\|10450039_10450624_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	5.55868e-29
NZ_CP017717.1\|WP_080044386.1\|10465006_10465444_+\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	3.34061e-36
NZ_CP017717.1\|WP_080044371.1\|10448369_10449179_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.46769e-26
NZ_CP017717.1\|WP_080044382.1\|10460457_10461210_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	5.4473e-42
NZ_CP017717.1\|WP_080044385.1\|10464212_10465010_+\|2-keto-4-pentenoate-hydratase	gnl\|CDD\|183092	PRK11342, mhpD, 2-keto-4-pentenoate hydratase; Provisional.	4.31647e-108
NZ_CP017717.1\|WP_080044376.1\|10454966_10455248_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	3.07802e-33
NZ_CP017717.1\|WP_080044373.1\|10450763_10452890_+\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	1.42052e-86
NZ_CP017717.1\|WP_080047416.1\|10449190_10449949_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	8.53968e-19
NZ_CP017717.1\|WP_080044389.1\|10466938_10468054_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380667	cd20014, PBP1_RPA0668_benzoate-like, type 1 periplasmic binding-protein component of an ABC system (RPA0668), involved in in the active transport of lignin-derived benzoate derivative compounds, and its close homologs. This group includes RPA0668 from Rhodopseudomonas palustris and its close homologs in other bacteria. Rpa0668 is the periplasmic binding-protein component of an ABC system that is involved in the active transport of lignin-derived benzoate derivative compounds. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).	2.02216e-124
NZ_CP017717.1\|WP_080044388.1\|10465956_10466925_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	6.87798e-24
NZ_CP017717.1\|WP_080044384.1\|10462684_10464220_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|132260	TIGR03216, 2-hydroxymuconic_semialdehyde_dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase. Members of this protein family are 2-hydroxymuconic semialdehyde dehydrogenase. Many aromatic compounds are catabolized by way of the catechol, via the meta-cleavage pathway, to pyruvate and acetyl-CoA. This enzyme performs the second of seven steps in that pathway for catechol degradation. [Energy metabolism, Other].	0
NZ_CP017717.1\|WP_080044387.1\|10465440_10465956_+\|3-hydroxyanthranilate-3,4-dioxygenase	gnl\|CDD\|183930	PRK13264, PRK13264, 3-hydroxyanthranilate 3,4-dioxygenase; Provisional.	1.67514e-109
NZ_CP017717.1\|WP_080044379.1\|10457989_10458520_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	1.69017e-69
NZ_CP017717.1\|WP_080047417.1\|10461962_10462667_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	8.45689e-43

>NZ_CP017717.1|WP_080044379.1|10457989_10458520_-|gamma-carbonic-anhydrase-family-protein
MSRMYIAALDNGAVPDIHPEAYIAPGAVVVGDVRVGRASSIWYGSVLRGDDERIEIGAECNVQDLSCLHADPGEPAILEDRVSLGHKAMVHGAHVETGALIGIGAIVLGGARVGAGTLVAAGALVGPGKKIPAGVLVAGVPGRIVRELTDDDRDSFARTPDNYMAKALRHRQASSL
>NZ_CP017717.1|WP_155128886.1|10457115_10458018_+|hypothetical-protein
MRAKVAGTLAVVSVLSGCGTTTAAQPTPTGAGVLTLENATPPAPGGEVGEASTEFDDAADLKMWTKLSDTEKDIDRLSKYDVNKTAKGAMYLEPNVSAWFDGFRGPFVYQDLAGDIVMHARVKVEGKSGGQPKRKFSLGGLMARQPGSYAKPNWVSVTTGTAEKSGQVEAKYTQDGSSKPKEIAVKSGWVDLVLARVGRVFVALYKEDKGTWKVAQRWPSSLPDVLQWGVTAYTDWDSYSTLKKDATKGNAKQVKGTPDLKLTVDFVRFLRPELPEYADPLNPASVSDEVLVKVMTPAGA
>NZ_CP017717.1|WP_080044377.1|10455745_10457062_-|hypothetical-protein
MTAVPPWDAFTAAEAEVRAMVADPRWQGLSVPDRAHVLAARILVTPDGDRWLFGAHARWHLHDPADGRWHPAPPPRGTRVRRVTHAAAVLPDDVVPPGHDFHAEPGSTQSFIGPDVPERLTEQLRQLVRACGRKSELDYPLSAFGEIFATDVPSTVAAVWGTIMWCAYAPAFDGNERLITVFGEYLRRSLPGDEWVRWLPAPPLLDLVTLVAERMRAGRPRAALRLAAVMADTAQILLLDTRFRPRALALLTMVEPMLRRPGFGDPYDDDAVMRREWLARCPARLCRALLVENDPEAHFSHTVYDLVDALAFMPEPREAAATFLADLSDSKGALPGRLDHRLRMAYEELRRAGLTGTSAAETTQPEGFPVRAEGVAPPLEVAPPDRGSTAAVLGAAYATALAWERLTGAKLPARGLASQSALVRRIVHERDDHHTGHM
>NZ_CP017717.1|WP_080044376.1|10454966_10455248_+|metal-sensitive-transcriptional-regulator
MHGYSGDKQAYLTRLRRIEGQIRGLQRMVDDDAYCIDVLTQVSAATRALQAVALGLLEEHISHCVADAINTGGPEAEAKVKEASAAIARLVRS
>NZ_CP017717.1|WP_080044375.1|10453869_10454937_+|glycosyltransferase
MKVSMVLPSAYAMRGDVRATLNLATALAERHDVEVISVRRQKEKPFFPVGPKVSMRSVVDVRPGVRHLLPRGQVRTEVALWRVLRNLRSDVLITTRPGIGVQAARHAPRDTIKIAREWGRPAVPGPVKRFYPRLSAVVTATESAQEEWSRLLGDTPVVHSVLDALPGGPWPRSRMDNRIVAAGGRWVPVKAYDRLIRSFAIVADKRPDWRLRLYGGGPEERRLRALVRELNLHNHVYFMGTTPDLAGEFAKASIVATTSRSEDLGMTVLEAMGCGVPVVAFEGARGPREFVATGYNGVLVPDSEGDPQLFAAALLALIDDERRRRSLAAGALDTAVRHSADEVAEQWEKLIADLR
>NZ_CP017717.1|WP_080044374.1|10453069_10453873_+|hypothetical-protein
MGVVVTDAEVTLADVLSLRLAIDEPLEDGTELVLRHRTTGVERDVLLGSPGARAREATLAVSLAPLELSAGRWDAYLRHDGKRSRLRSVDPGFSLDHLDAYALCRRTLAYRSYRTRNGFLALKISDAEPVAEVRSIWFREGRFEVMGLLAYTGLEDDDSRHEAVLTLERRQTGAHLKATATVQGVRFHAAVSLVDVLAADPEEAEGAAMWEPALQVEGVPTALRLGSRLDDVDGKRRRLHYPSARVDGVLIKPCYTADDELRIEVGG
>NZ_CP017717.1|WP_080044373.1|10450763_10452890_+|(Fe-S)-binding-protein
MLWVAIIGLVMTVAAVAVAGRRVMFLFKLATVGAPAPERVEYARTHVGDEIKAQLVEVFGQKKLLKWTPSGVAHFFVMWAFFILLTVYIEAYGAIIQGAITGTPDFHIPLIGTWGVLGFLQDFIAVACLLGLVAFAIIRVKNSPKTLGRRSRFSGSHLGGAWLVLFMIFNIIWTLFLARGAAAANGNFPYSSGAFVSLALGDVLPASGLLEEIALLLHIGFMLVFLVIVVNSKHLHVFTAPLNVLFSRRPDGLGGAPEMRVDGKPVDFEDEDLDPERLGRGKIGDTTWKGFLDFYSCTECGRCQSQCPAWNTDKPLSPKMLILDQRDHAFKVAPYLLAAQAGVEHKDTDVLALLEKPLVGEEGVIHPDVLWSCTNCGACVEQCPVDIEHIDHILDMRRYQVMVESSFPSEAGVMVKNLENKGNPWGMSEMKRADWIEELATSVDGQHVEVPMVEDKMPEDAEYLFWVGCAGALEDRAKKTTKAVAELLHIAGVKFAVLGPMEACSGDPARRLGMEYLFNMLAQQNIETLNEAGVKKIVATCPHCFNTLANEYPQLGGTYEVVHHTQLLSKLVDEGLLTPITPIEEKITYHDPCFLGRHNKVYSQPRDIMAKVPGVQTQEMHRHKDRGFCCGAGGARMWMEERIGKRINTERVDEALTTNPDTVSTACPFCMVMLGDAINEKKNNGEAKESLEVVDVAQLLIKSVKGAS
>NZ_CP017717.1|WP_080044372.1|10450039_10450624_+|TetR/AcrR-family-transcriptional-regulator
MSTDRRRPGRRPGAADTRGEILTAARRVFSEKGFDKATVRGIAREAQVDPALVHHYFETKEGMFAAAMELPINPQQILPVLLEGPREEVGERLVRLLLRLTAEEKTRAPMLALLRSAVSNEQAVGMIREFFTSALIFQVADRLGVPHLRIEAAFAQMLGVVMARYVLKLEPLASASHDELVEILAPTIQRYFTG
>NZ_CP017717.1|WP_080047416.1|10449190_10449949_+|class-I-SAM-dependent-methyltransferase
MKDLGRTFDLVADAYDAARPGYPDEVYRALSELSGVELDGATTVDVGAGTGIMTHALRARGSHVIAVDPGEAMLARLVSKAGRPNGTRVSALLADGNALPLADEVADLVTYAQSWHWLDPVASIAEARRVLRPKGAIVGCWNLNHAAQADWLAAYEARLAEEVPAYWGPAVEQWSVPPIAAAFEVIEERWIPWTRLIGIDDFLLDLRSHSYMAALSAERADEVVERQRVALRAEFPEGVLSVPMRVYLAVGR
>NZ_CP017717.1|WP_080044371.1|10448369_10449179_+|sugar-phosphate-isomerase/epimerase
MADVIRVPNAKIALSTASVYPERTPDAFELAARLGYDGVEIMVGADPVSQDIDVIERLSDHYEVPVLAIHAPCLLVTQRVWGRDPWAKLVKAQKAAERLGASTVVVHPPFRWQRDYARDFESGLARMRDETDVTFAVENMFPLRARGNDVVPYSPDWNPIDHDFPQVTLDLSHTAVSGSDAMEMAVKLGDRLAHLHLADGVGVTNKDEHLVPGRGNQPCAQMLERLANTGYSGLVVLEINTRKAASRTERIDDLAEGLAFARLHLAAST
>NZ_CP017717.1|WP_080044381.1|10460091_10460334_-|hypothetical-protein
MSFDRHLAEIAREYPQWTIWRSDAGRWWATRHHPLSAAQRDAGCAMTIDADDPDGLRDRLRDQERRAGERHTWRAGPAPP
>NZ_CP017717.1|WP_080044382.1|10460457_10461210_-|GntR-family-transcriptional-regulator
MSESPVPHEPPIYRRIADGLRARILAGELRDGDRLPGENALMAEYAIARATARQALAVLINEGLAVPRRGSGVYVRLFKPIRRHGSRRLSREQWGQGRAIWDADTRGRPFTVDALEVVLERATEDVAVVLESGEVWVRRRRYSVDGRPVQLATSSFPARLVEGSAITLPDTGPGGVYARLGDLGLAPAHFTEEVRARMPGPRESRLLDLPAGTPVIVIARTAYTSGGLPVELNEMVLDSAAYVLQYDFDA
>NZ_CP017717.1|WP_080044383.1|10461351_10461906_-|VanZ-family-protein
MARTWELWGNVIIAGTFALPLALLAIVILSRHRARAGRPAPLRTSLADVGIVVGTAPWIWMILTPSDGPSGVNLVPFTDLADLARAPWEAVFVQVGGNLLVFAALGALLPVRGRAMSSLGRVAALAAAFSVLVEVLQYVLRLGRLSSVDDVILNTTGAVIFALVTRRWWARTDTGRDRSTITAR
>NZ_CP017717.1|WP_080047417.1|10461962_10462667_-|dienelactone-hydrolase-family-protein
MQTRTDRIAAHDGSFDVRVWLPDSGSGPGLLLVQEIYGVGPYIEKVATDLAARGYVVAAPDLFWRLQPGYVGEHTPEGTQAAIELSQGFDLAQGVADCALTVAHLSALPEVRGGVGALGFCLGGSVDYMLATQVELAAVLSFYGSAVPDATGLMERISSPLLLVFGGSDPYIPRERVAAVEKAAEGRPNVVVHVEEEAGHAFHNSESPMFHQPEPAARAWEVAIAFLDEHLPAR
>NZ_CP017717.1|WP_080044384.1|10462684_10464220_+|aldehyde-dehydrogenase-family-protein
MARAAFGRDDAIEEVPCPRNFLLSTSRTAIYTGRRGRDEERVVLTHFIGGQPVGAGKAFPVHDPVTGAVIRQVHEADPEVVDRAVRAAREAARDWAAMPVGERAGWMRRLAEGIEARFDDLVAAEIADTGKPLDQTRTLDIPRGIANFRAFADIAAQRPEDAFHLSGVLSYTVRRPLGVVAVIVPWNLPFLLMTWKLAPALVSGNTVVVKPSEQTPGSAAVFAEICAESGLPPGVVNIIFGHGSAGQLLVEHPGVDAVTFTGSTATGRTIMRSVADRVKPISFELGGKNAGLVFEDCHLDKAVEGTVKSVFTNGGQVCLCTERVYVHRSIFEDFCARLAVRAQEVELQPMISAEHREKVLSYYALARSEGAKMLAGGSVPVFGDHRDSGYFVEPTVVTGLSEWSRFNREEIFGPVCHVTPFDSEAEAVDLANGSEYGLAATVWTTNLDRAHRVAQRLEAGLVWVNTWYLRDLRTPFGGVKLSGIGREGGTRSLDFYSEPTTITIKLEQPDA
>NZ_CP017717.1|WP_080044385.1|10464212_10465010_+|2-keto-4-pentenoate-hydratase
MHDEWSQAVDVRAQAAERLAEAVRTGRPCAPIRDLVGTAADAYAVQELGTRQALDAGRRPVGRKIGLTNPVIQQQLGVDQPDFGVLFADTCYGDGLPVPPERFLQPKAEAEVALVLGGDLEGGPFTVADVIRAVDFVLPAIEIADSRIAGWDISLVDTIADNASSGAFVLGGTPMSLRGLDLRAARMSMTRGDQEVSAGSGEACLGHPLNAAVWLANRLGGTEHPLRAGDVVLTGALGPVVPVEPGDVFEARIEGLGSVRAVFGK
>NZ_CP017717.1|WP_080044386.1|10465006_10465444_+|RidA-family-protein
MSPQARPKAIRVPGKATPRGRFPHVKRAGDFLYVSGTSCRRPDDTFVGAEVDKYGVTNLDIRAQTRAVIENIGDILKAAGGSLADLVQITTYLVNMNDFKGYNEVYAEFFDEEGPTRTTVAVHQLPHPHLLIEMQAVAYHPQELS
>NZ_CP017717.1|WP_080044387.1|10465440_10465956_+|3-hydroxyanthranilate-3,4-dioxygenase
MIPPIDFTAWIDEHAHLLKPPVGNKVVFEGANDFIVMVVGGPNSRTDFHVDPYEELFYQVRGNMHVNVVTGNGPETVHVREGQMWLLPPRVPHSPQRPEAGSVGLVVERIRPEGELEKFQWYCMECGALVHEVELQVRDIVKDLPPVFEAFYGDEKARTCGRCGALHPGKG
>NZ_CP017717.1|WP_080044388.1|10465956_10466925_+|amidohydrolase
MVIDVHTHHVPRGWPELGWPGAPRLRVDSEREATILVNDREFRRIQDDCWDPRVRLERMDRDGVDRQVVSPTPVFFGYDRPAEQGVRIAKVFNDLALELCAGPRLIPFCQVPLQDPDLACAELDRCLANGHRGVEIGNHVGDRDLDDPGVVRFLQHCAERNVPVFVHPWDLPAGPRVERWMAQWLVGMPAETHLSILAMILGGVFDRVPDTLRICFAHGGGSFAFWLGRFENAWHRRHDLVGGSERPPSHYLGRFSVDSAVFDERALRLLVDTLGEDHVMLGSDFPYPLGESPAGDLIRRAPFLSGTARAKLLAANAEAFLG
>NZ_CP017717.1|WP_080044389.1|10466938_10468054_+|ABC-transporter-substrate-binding-protein
MRAPVLGLPVVGLVVLMAAGCGGTVPPRDGDELPVKIGAIISQTGVYAMLGDDMESAMRLYLDDHGGRLGGRPAELLVADDGGTAEQGRKEARRLIDAESVDVLTGLIASPVAVAVVEEAAGRTPVVVANAGSDDLDGSNVFRVSYTNHDHGHAAGRYAAEHYGRRGVVLMAPDYSAGVETLDGFTEGYGAEPLKRILTPHDRVADLRPYFEQIPPEAKLLYAFYAGGEAIAFTRAFKELGYDTRIDLLACMNLTDEDVLRAVGPDAEGITSVGMYSPALENIDNTAFAAKWRERTGRNPSAVAVQSWDAMRLIDAALSRGGDLGRALGEVGELDGPRGRFRLDATHNPVQNWYVRRYQNGVNRVIATIPP

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Crispr_ID: NZ_CP017717_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_33

10744878-10744957

Orphan

Consensus_repeat	Method
CGCCCTGGCAGCAGCCGCCCTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_33

>merge|NZ_CP017717|33|10744878-10744957|CRISPRCasFinder
CGCCCTGGCAGCAGCCGCCCTCGACCGGAGAGAGCGCCTCGTCCGGGGAGAGCGCCGCGCCGTGGCAGCAGCCGCCCTCG

>NZ_CP017717|33|30|10744878-10744957|CRISPRCasFinder
CGCCCTGGCAGCAGCCGCCCTCG	ACCGGAGAGAGCGCCTCGTCCGGGGAGAGCGCCG
CGCCGTGGCAGCAGCCGCCCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_013133571.1\|10737069_10737273_-\|developmental-transcriptional-regulator-BldC	unknown	unknown	gnl\|CDD\|133390
NZ_CP017717.1\|WP_155130082.1\|10735052_10736045_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP017717.1\|WP_080044624.1\|10737595_10738459_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080044646.1\|10754629_10755292_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP017717.1\|WP_155128936.1\|10751724_10752372_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|172294
NZ_CP017717.1\|WP_080044629.1\|10742752_10743496_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP017717.1\|WP_080044630.1\|10743583_10743991_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP017717.1\|WP_080047439.1\|10755325_10756870_-\|adenylyl-cyclase	unknown	unknown	gnl\|CDD\|143636
NZ_CP017717.1\|WP_080044635.1\|10746288_10748361_+\|PhoX-family-phosphatase	unknown	unknown	gnl\|CDD\|225752
NZ_CP017717.1\|WP_080044642.1\|10752382_10753129_+\|5,10-methylenetetrahydrofolate-reductase	unknown	unknown	gnl\|CDD\|223757
NZ_CP017717.1\|WP_080047438.1\|10739797_10740028_+\|DUF3073-domain-containing-protein	unknown	unknown	gnl\|CDD\|378620
NZ_CP017717.1\|WP_080044636.1\|10748395_10750279_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP017717.1\|WP_080044627.1\|10740243_10741269_-\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NZ_CP017717.1\|WP_080044626.1\|10738566_10739646_+\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NZ_CP017717.1\|WP_080044644.1\|10753089_10754574_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP017717.1\|WP_080044638.1\|10750236_10751655_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP017717.1\|WP_080044628.1\|10741265_10742702_-\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236113
NZ_CP017717.1\|WP_080044633.1\|10745736_10746159_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380033
NZ_CP017717.1\|WP_155130085.1\|10757550_10758411_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|189968
NZ_CP017717.1\|WP_080044622.1\|10736347_10736920_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_013133571.1\|10737069_10737273_-\|developmental-transcriptional-regulator-BldC	gnl\|CDD\|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	6.46983e-14
NZ_CP017717.1\|WP_155130082.1\|10735052_10736045_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	5.38984e-107
NZ_CP017717.1\|WP_080044646.1\|10754629_10755292_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.44918e-36
NZ_CP017717.1\|WP_155128936.1\|10751724_10752372_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	2.52802e-10
NZ_CP017717.1\|WP_080044629.1\|10742752_10743496_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.93489e-47
NZ_CP017717.1\|WP_080044630.1\|10743583_10743991_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.32105e-18
NZ_CP017717.1\|WP_080047439.1\|10755325_10756870_-\|adenylyl-cyclase	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	8.65026e-60
NZ_CP017717.1\|WP_080044635.1\|10746288_10748361_+\|PhoX-family-phosphatase	gnl\|CDD\|225752	COG3211, PhoX, Predicted phosphatase [General function prediction only].	0
NZ_CP017717.1\|WP_080044642.1\|10752382_10753129_+\|5,10-methylenetetrahydrofolate-reductase	gnl\|CDD\|223757	COG0685, MetF, 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism].	2.04633e-22
NZ_CP017717.1\|WP_080047438.1\|10739797_10740028_+\|DUF3073-domain-containing-protein	gnl\|CDD\|378620	pfam11273, DUF3073, Protein of unknown function (DUF3073). This family of proteins with unknown function appears to be restricted to Actinobacteria.	5.77379e-16
NZ_CP017717.1\|WP_080044636.1\|10748395_10750279_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.03462e-164
NZ_CP017717.1\|WP_080044627.1\|10740243_10741269_-\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	1.60001e-177
NZ_CP017717.1\|WP_080044626.1\|10738566_10739646_+\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	1.38952e-97
NZ_CP017717.1\|WP_080044644.1\|10753089_10754574_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.0994e-57
NZ_CP017717.1\|WP_080044638.1\|10750236_10751655_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.8349e-69
NZ_CP017717.1\|WP_080044628.1\|10741265_10742702_-\|amidophosphoribosyltransferase	gnl\|CDD\|236113	PRK07847, PRK07847, amidophosphoribosyltransferase; Provisional.	0
NZ_CP017717.1\|WP_080044633.1\|10745736_10746159_-\|hypothetical-protein	gnl\|CDD\|380033	pfam17844, SCP_3, Bacterial SCP ortholog. This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.	6.04557e-49
NZ_CP017717.1\|WP_155130085.1\|10757550_10758411_+\|hypothetical-protein	gnl\|CDD\|189968	pfam01391, Collagen, Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.	2.57795e-07
NZ_CP017717.1\|WP_080044622.1\|10736347_10736920_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.99301e-11

>NZ_CP017717.1|WP_080044630.1|10743583_10743991_-|MarR-family-transcriptional-regulator
MLDETLTYALIKLMKAHRNQLAAALIPLGLHVGQELLLNQLWREDGLTQGELIARLGVEPPTVTKTLQRLERVGFVYRAPDPDRPRIGRVYLTDAGKALREPVEAIWRELDADLQRGFTQEERELLAKLLRVGQS
>NZ_CP017717.1|WP_080044629.1|10742752_10743496_-|SDR-family-oxidoreductase
MHVLVTGGSSGIGAATALAYARTGADVTITYNQGADRAAEIVRRVEKEGVRGAAVHLDLEDHSTIAPAVAQTGPVDALVANAVRWGTVQPGSMAFEDVPAAEWSAALHANVAGNALLIQAVLPEMRRRQWGRIVLVSSGIAEEGVPGPGPYGTAKMALHGMARALAWEAGKDGILVNVAVAGLTVTGVRAFPQEVLDRLAARTPSRRLSTADDMAALIVFLGSAANHNVTGEIIRDGSNAGRSAHAL
>NZ_CP017717.1|WP_080044628.1|10741265_10742702_-|amidophosphoribosyltransferase
MLKGDGRLGHDLDPHDRAPKDACGVFGVWAPGEEVSKLTYYGLYALQHRGQESAGIAVSEGSRILVYKDMGLVAQVFDESVLSTLRGHLAIGHCRYSTTGSSVWENAQPTLSSTEVGGLALAHNGNLINTPELAQRLAPGSIRATTDTEVLTTLLAQDRSRSVEDAAAELLPQVKGAYTLVFMNEKTLYAARDPQGIRPLVLGRLERGWVVASETAALDIVGATFVREVEPGELLTIDEQGVRSRRFALAEPKGCLFEYVYLARPDTTIAGRGVQVTRVEVGRVLAREHPVEADLVIPTPESGTPAAVGYAQESGIPYGQGLVKNSYVGRTFIQPSQTIRQLGIRLKLNPLREVVEGKRLVVVDDSIVRGNTQRAIVKMLREAGAREVHVRISSPPVKWPCFYGIDFATRAELIAGSLSVEEIRASLGADSLGYISLEGLTEATTIPSDRLCRACFTGEYPIPIDQDNVGKFVLESKA
>NZ_CP017717.1|WP_080044627.1|10740243_10741269_-|phosphoribosylformylglycinamidine-cyclo-ligase
MSTYEAAGVDIEAGERAVELMKDKVARSRRPEVVDDASGFAGLFDASALLKYQRPLLATSTDGVGTKVMIAQQYGKHDTIGIDLVGMVLDDLVVCGAEPLFMTDYVACGKVVPERIAEIVGGVAEGCRLAGAALVGGETAEHPGAMGPDEYDLAGAGTGVVEASAMLGPDRVAAGDVVLAMASSGVHSNGYSLVRHVLRESNLSLDAVLPELGRPLGEELLEPTRIYSLHCLELARAVEVHAYAHITGGGIESNLARSLPPGLDALLDRSSWTPPAIFGVLSAYGKIAQRDMDRTFNLGVGMAAVLPAEAADAAIGLLAGRGLDAWVMGEIAPGTGQARYR
>NZ_CP017717.1|WP_080047438.1|10739797_10740028_+|DUF3073-domain-containing-protein
MGRGRAKAKQVKVARQLKYNSGGTDLDRLRDELGVGDSSRNDDADDLNDELADRYADYADDYGAGDDDDGRTSGRR
>NZ_CP017717.1|WP_080044626.1|10738566_10739646_+|Glu/Leu/Phe/Val-dehydrogenase
MTDVFGASHKDVHEQVVFCADEQSGLRAIIAIHNTALGPALGGTRFYPYESESAALADVLNLAKGMAYKNALAGLDLGGGKAVIIGDPARDKSEALLRAYGRFVESLGGRYITACDVGTYSEDMDVVARESRFVTGRTTANGGAGDSSILTAFGVFQGMRASAERVYGTPSLHGRRVGVEGVGKVGHRLVELLREDGAEVVICDVDPKAVERVRLRHPEVDVVADARTLMASDLDVFAPCALGGALDDETVTTLRAKIVCGAANNQLAHPGVEKQLAERGILYAPDYVVNSGGVIQVADEIGGFDMERARSKAAQIYDTTLKIFAIAADEGVPPAVAADRLAERRMSEVGRIRAIWLGH
>NZ_CP017717.1|WP_080044624.1|10737595_10738459_-|hypothetical-protein
MLPYAAYLRVYEPLTAFAESERKVWADYADSRDRPRRANALNAEHGESVMRLLGMPPQPVPAQESPNAYLRRVEDRLYVCPWQTRLRSWLAFSRLRGTTPVKLMDHLVPKAIAEQTADDFDRYKRQAGSAALRTHIRTTAWHVPPSWFVPFDGNERWLVLGSANPGQDVTTTTGRNLIYVTSMAQARRRTARALSVLRRHLGDVAANFDVEDVARWLEEFHPHSLVELDYGGLVHLMDDDALQADQSVAELSAALTGLDTGQEELAYAMYQRVILRWKSMQLLESAN
>NZ_CP017717.1|WP_013133571.1|10737069_10737273_-|developmental-transcriptional-regulator-BldC
MSARTPEAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGGHRRYRETEVRALLAGIPQQRSE
>NZ_CP017717.1|WP_080044622.1|10736347_10736920_+|TetR/AcrR-family-transcriptional-regulator
MAAALELFSTRDAEDVSIDDVASAAGASRALVYHYFGGKQELYVAALRSAAEQLESRLRPQGGGRPLDELASGLSRYFDFVEEHAAGFAALLRGGPANRTGEVGEIVDGVRRRLFRLIQKQMGVEEPSPVLRTTLRSWIASVETAGLDWLEHRDLERPMLENMLVQHMVALLGVAAAHDGEVAGLLERLA
>NZ_CP017717.1|WP_155130082.1|10735052_10736045_-|LacI-family-DNA-binding-transcriptional-regulator
MPRPRPTIRNVAERAGVSKSLVSLVLRGSPHVSEHRRQAVLQAARELGYRPNAVARSLVEGRTHLVGALVADLHNPFYAEFLDGLQESLHGDGLRMLIGNSQWDPAFEDEAVEAFLELRVDGLVLLGIPPTSETLIEATAYTPTVVVGERDIELDGVDIVVDDDQLGARLAIDHLVEHGHKRIAHIEGRRSSRCEGYLVAMRRHSLAPYIMVEAADSTEEGGREAATALLTRDPRPTAIFAANDVVALGVLSAASELGLRVPEDLSVVGYDNTHLSASHHISLTSVDQARRSMGRSAAALLSDRIGDPAKAARLREVRPELIVRRSTGPA
>NZ_CP017717.1|WP_080044633.1|10745736_10746159_-|hypothetical-protein
MDQEKLRAALDGQLVALDEPAYDGPAAALPDALVAAVLAAYERGLQPERDAGRMAVRHLLDKLASAAPGRTVEVRVPPYAAVQAIEGPRHTRGTPPNVVEMDGRTWIELALGRLTWDEAMAKGAVSASGARADLSGYLPL
>NZ_CP017717.1|WP_080044635.1|10746288_10748361_+|PhoX-family-phosphatase
MANPNAGRRLLPLLSTPHKGGRSALTCQFRCGNACAHDVANTTGNAYFGDVVKEALSRRGVLRAGALGAVVVGAGVAGAVPALADEPGVSAAGHGWSGGGSDIRFTAVRPNKDDKLTIPDGYQSSVVVRWGDPVLPDAPAFDFDNQTADAQSKQFGYNCDYVTVFPMGRDRALMWVNHEYTDESLMFRGYTGGAAATEEQIRIGLAAHGGSVVEIERAGRTGEWKLVTKGRRRYNRRITAQTPMRFSGPAAGSDLLKTAADPKGTTPVGMLNNCSGGTTPWGTVLTTEENFNQYFVNADKVPAAQQPYISRYSITTGTPSSSRRFDRVEERFDLAKHPNEVNRFGWIVEIDPFDPDSTPVKRTALGRFAHEAATTTLARDGRLVVYMGDDGRFEYIYKFVSKNRYIPGFDRHNRALLDEGTLYVAKFTGDSPASEIDGSGKLPSDGLFDGSGEWIPLVSGDRSYVDGMSAQEVLVYTRTAADKVGATKMDRPEDIERNPVTGGVYVALTNNSNRTAAQVDEANPRPSNKHGHVLEIVERRNDAGGRTFAWSLPLVCGDPNDASTYFAGFDKTKVSPISCPDNVTFDKDGNLWISTDGNALGMNDGLFVMPVKGRERGYVRQFLTVPVGAETCGPLVSDDQRSVFVAVQHPGETDGASPDAPSSRWPDGEGSQPRPSVAVVWHAQGKKIGA
>NZ_CP017717.1|WP_080044636.1|10748395_10750279_+|ABC-transporter-ATP-binding-protein
MSMEVTAWHQLYSMNNRPERRSVSRATLRRIGAFARPHRRKLTLFLLLSVVTAGLAVGAPLLAGRVVDAIFSGEPLGVVVTVALAIAGLAIAEAGLGLVNRWLSASLGEDLILDLRTAVFDHVQRMPVAFFMRTRTGALVSRLNNDVIGAQRAFTDTLSGVAGNIVTLALTLVAMVGISWQITLLALLLLPVFVLPARRMGTRIARLRREAADHNAAMGTQMTERFSAPGATLVKLFGRPAHESAEFARRARRVRDIGVRSAMTQSAFVTALTLVSALALALVYGLGGFYALAGQLAPGALVSMAMLLTRLYAPLTALASARVDVMSAVVSFERVFEVLDLKPLIQDKPDAREVPEGPVSVEFDDVRFAYPSADKVSLASLEEVATLDTRGGVEVLHGVSFRAEPGQMVALVGSSGAGKSTIAQLLPRLYDVDSGAVRLGGVDVRDLSADSIRDTLGMVTQDGHLFHDTIRANLLLARPEADEAEIWDALTRARLADLIRSLPDGLDTMVGERGYRLSGGERQRLTIARLLLARPRVVILDEATAALDSTSEAAVQAALGEALEGRTAVVIAHRLSTVRAADLILVIEDGRIVERGTHAQLLAAGGRYEELYRTQFEDPTVSGVAAA
>NZ_CP017717.1|WP_080044638.1|10750236_10751655_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MRWWALVAVTLGTFMTYLDNNVGNVALPTIQRELGLTISGLEWIVSSYILVFAGLMLVGGRLADVLGARRVFLGGLAVFTVASLAAGLATSGGALIAARAAQGVGAALLTPTTLALIGQIFPDPAERGRAVGIWSSAGALSMALGPALGGFISEHLHWGWIYLINVPLGLVTAGIAIRALPAAARRVRHSLDLPGLTLSALALFALTFALIEGETLGWTSAPILAAFGGFAAAVAGFVAVESRAAEPMIAISLFRSRVFTGGMLTSGIWSFGVFGIYFFSALWLQNVLGFSPTQAGASFVPMALVMGVVALLSQQVSARLGIGRTVALGMALMGSAIFLLSRVGADGDFADVAPWFILYGLGGGLLVPLTAAVLNGMPKGRSGVASGVLNVSREVFGLLGITVLGALLTATQNASGLPPLPAFLDGYRFTLVVAAVVVLAAIPVALWSLRPQPAPPEEPQAAATPETVGSSN
>NZ_CP017717.1|WP_155128936.1|10751724_10752372_+|TetR-family-transcriptional-regulator
MMGKLTAQAIAERALEIGDTEGIDAVTIRRLATDLGVTPMALYWHFKNKEQLLVGMADHLIGGFAPKPADDRPWQAQLRDLTEGLIRALRTHPCAKNVLEQIDPVAVPNFLAVWNHALGLARAAGFGVDESCLITKYLLQSAIAIADAPVHGQAEPDREARVRAKMVGLQSLPVETYPYLVEMARPLVGGTDPVLYDTFGVDLVLGGIEALAGRR
>NZ_CP017717.1|WP_080044642.1|10752382_10753129_+|5,10-methylenetetrahydrofolate-reductase
MPFEPICEIEPPTKPDLKHVRHQIGTLSKIAHAFLIPDNHIGRATVSSVAVAHEVEAMGGRGIACLNSRDRNLLGFRRDLLTAAAYGVDQFLFVYGDKPTSGNRTGDLNVRSMIEEARAFSADFRVGAAAGLRPLPAWKRTADFLFSQVSFSVEQQLRWREAHPVDVPVYAGVMVLASERHARTLAAAIPDIALPEELIARVAADRMAGVEAACEQVLALRDSGAFAGVHLVPVARYRDVESRLAGAL
>NZ_CP017717.1|WP_080044644.1|10753089_10754574_-|MFS-transporter
MVAVTPQDGTRMRYAWRVCAVTSLGLVLIGIAGSTLNVALPTVVRHFRADALESGWILLSFLLVNTASLVLFGRVADLLGRREVYLAGFALFTVASLLAGLSPGVWFLIAMRVLQAIGAAMILANGTVIITDAFPPERLSQGMGVYIGTLSVAQLAGPTLGGLIAETAGWQWIFWVNVPAGLLALGVGAAILRKMPRRPKEPVDALGNVLVFAALSALLLALSTAGSSGPTSPVVLAGAGLFVVLVPLIVLAERRAPNPVLDLRLFGGRLLTCANLASFCNALARSALILVVALYFQAARGVDAFTAGLSVLPVPVGIGLASPIVGLLGQRISPYALSIGGAVMSAAGLGTLMLTADPGTPYWVIGIGLFVAGCGSGTFLTGNTTQVMRALPAGSLGVVNGFRVMVMNVGIVISVGLSLSVLTASVGPQVRAQVYAGTLSTLSPVAVGQLMDGFQRAYAVLFGVALIGAVLAALARQPQSAPQSAPARRDSTSR
>NZ_CP017717.1|WP_080044646.1|10754629_10755292_-|Crp/Fnr-family-transcriptional-regulator
MDAEPGEFLTMLTAEEVEDLRSAGRLRRWDRGTTIMTEGDTSDWVLVLLDGRVKCSSHTSSGTEVVLAVRGPGALLGELSAIDGSPRSTTVTALEPISGIVVRDFISFLESHGRIAVLLMRLISGKLRDSDRKRIEYGAFDTTGRVATRLLELADRYGEKTNSGVRVALPLSQDELAGWTGASREAVSKALRTLRDRGLIETGRRRVVIHDLEGLRKRAR
>NZ_CP017717.1|WP_080047439.1|10755325_10756870_-|adenylyl-cyclase
MALWGVVSLVPGLTPLSEPPMVSPMDWLMWASVPGLLLYAAASVMMFLLHRRRPAAMLISLITAYALLAESMVAGMSQLNWHLSWWEWHILLTLAFVFVAYSSYLQFRREGSSAGLFDSVALAATVRRIQRDYDEALEELVEHVRRGEPLAAARLSGKFRLNEGQAAVLDRAGEALANERELSERLAALVAVSAQTKVGLPENELLTVSLERVRQAYGDVKIALVSEGRTQIGSRDYAFTDGNPIRRDQLLAFPLTVKGNLAGVLEVPVGRTSQDEALAATLAGQLSISLENARLYQELHTLFHQYMSPDVAHALLADPAQAELGGQLKELTALFADLKGFTTFSEKVTPGEIVEMLNRYHTAAVPCILNNGGTIVQFVGDALLALFNAPATQTGHARQACRAALQMQQAAAEIAEEMAWKVDTVEWPTFRVGVNTGPALVGNIGSPELRGFNAMGDAVNVAARLQALAEPGTVVIGETTYRQLGDGVKVKSLGALNLKGKEELVTAYVLEGLA
>NZ_CP017717.1|WP_155130085.1|10757550_10758411_+|hypothetical-protein
MKIRGGRTITLAAAGALAASLLTVGGVATASSAASEVHACVHKKTRYARIVNPTTKCRKTEERILIGGSSTSTTTVQQGEQGRQGERGPAGPQGKPGIQGPKGETGPVGPQGKQGEPGPAGPQGPKGADGKDGKDGLPGKDGKDGATGPRGPEGPKGDTGPQGPKGPKGDPGSGATYTTYTKTATIRGTGSETASCGYGGMVTGGGFSFGTLKNAVVTASMPSGNGWTVSVAKDDNGGGNDDYDRKAAAPTATPTATPSEQTFTHGGGNNGTSVSGTVYVVCMKKA

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Crispr_ID: NZ_CP017717_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_34

11414761-11414933

Orphan

Consensus_repeat	Method
GCGGTGGGCCGTGAATGCCCACCCCGACCAGGGAGGCAGCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017717_34

>merge|NZ_CP017717|34|11414761-11414933|PILER-CR
GCGGTGGGCCGTGAATGCCCACCCCGACCAGGGAGGCAGCGGGCCGTGGAGCCGTTCGTGCTACCCGAGGTCGTGGGCCGTGAAAGCCCACCGACGGTCACCCGGGACGATGGCACCCGGGATCCGGGGCTGCGGTGGGCCGTGAATGCCCACCCCGACCAGGGAGGCGGCGG

>NZ_CP017717|34|2|11414761-11414933|PILER-CR
GCGGTGGGCCGTGAATGCCCACCCCGACCAGGGAGGCAGCGGGCCG	TGGAGCCGTTCGTGCTACCCGAGGTCGT
GGGCCGTGAAAGCCCACCGACGGTCACCCGGGACGATGGCACCCGG	GATCCGGGGCTGCGGTGGGCCGTGAATGCCCACCCCGA
CCAGGGAGGCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080045185.1\|11408941_11410078_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP017717.1\|WP_080045180.1\|11403720_11404470_-\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|237086
NZ_CP017717.1\|WP_080045197.1\|11426697_11427357_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP017717.1\|WP_080047492.1\|11424162_11425953_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP017717.1\|WP_080047491.1\|11422412_11422916_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP017717.1\|WP_080045183.1\|11407368_11407809_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_CP017717.1\|WP_080045181.1\|11404466_11406368_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236101
NZ_CP017717.1\|WP_080045196.1\|11425960_11426701_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP017717.1\|WP_155129085.1\|11420656_11422354_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238861
NZ_CP017717.1\|WP_080045195.1\|11422932_11424150_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NZ_CP017717.1\|WP_080045192.1\|11416869_11419266_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NZ_CP017717.1\|WP_080045188.1\|11411924_11413847_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236054
NZ_CP017717.1\|WP_080045187.1\|11411172_11411928_+\|succinate-dehydrogenase-cytochrome-b-subunit	unknown	unknown	gnl\|CDD\|239578
NZ_CP017717.1\|WP_080045182.1\|11406380_11407166_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045186.1\|11410110_11411040_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176102
NZ_CP017717.1\|WP_080045189.1\|11413843_11414584_+\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|181038
NZ_CP017717.1\|WP_080045190.1\|11414988_11415327_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379266
NZ_CP017717.1\|WP_155129082.1\|11419169_11420459_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225107
NZ_CP017717.1\|WP_080045191.1\|11415476_11416946_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224586
NZ_CP017717.1\|WP_080045184.1\|11407805_11408945_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080045185.1\|11408941_11410078_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	2.77982e-31
NZ_CP017717.1\|WP_080045180.1\|11403720_11404470_-\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl\|CDD\|237086	PRK12386, PRK12386, fumarate reductase iron-sulfur subunit; Provisional.	0
NZ_CP017717.1\|WP_080045197.1\|11426697_11427357_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	6.95534e-19
NZ_CP017717.1\|WP_080047492.1\|11424162_11425953_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	2.13547e-08
NZ_CP017717.1\|WP_080047491.1\|11422412_11422916_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.57195e-12
NZ_CP017717.1\|WP_080045183.1\|11407368_11407809_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.75228e-70
NZ_CP017717.1\|WP_080045181.1\|11404466_11406368_-\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236101	PRK07803, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_CP017717.1\|WP_080045196.1\|11425960_11426701_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.12249e-108
NZ_CP017717.1\|WP_080045195.1\|11422932_11424150_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	2.50273e-50
NZ_CP017717.1\|WP_080045192.1\|11416869_11419266_+\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	6.18371e-28
NZ_CP017717.1\|WP_080045188.1\|11411924_11413847_+\|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236054	PRK07573, sdhA, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	0
NZ_CP017717.1\|WP_080045187.1\|11411172_11411928_+\|succinate-dehydrogenase-cytochrome-b-subunit	gnl\|CDD\|239578	cd03498, SQR_TypeB_2_TM, Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. C. glutamicum SQR reduces low potential quinones such as menaquinone. SQR is also called succinate dehydrogenase (Sdh) or Complex II and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunit. The transmembrane subunit of members of this subfamily is also called Sdh cytochrome b558 subunit based on the Bacillus subtilis protein. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron acceptor (quinone). The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes. Proteins in this subfamily from G. metallireducens and G. sulfurreducens are bifunctional enzymes with SQR and QFR activities.	1.41812e-68
NZ_CP017717.1\|WP_155129085.1\|11420656_11422354_+\|hypothetical-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	2.93595e-13
NZ_CP017717.1\|WP_080045186.1\|11410110_11411040_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176102	cd05466, PBP2_LTTR_substrate, The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily. This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.85684e-53
NZ_CP017717.1\|WP_080045189.1\|11413843_11414584_+\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl\|CDD\|181038	PRK07570, PRK07570, succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated.	0
NZ_CP017717.1\|WP_080045190.1\|11414988_11415327_-\|hypothetical-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	0.00158186
NZ_CP017717.1\|WP_155129082.1\|11419169_11420459_+\|hypothetical-protein	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.60026e-16
NZ_CP017717.1\|WP_080045191.1\|11415476_11416946_+\|ATP-binding-protein	gnl\|CDD\|224586	COG1672, COG1672, Predicted ATPase (AAA+ superfamily) [General function prediction only].	2.02921e-07
NZ_CP017717.1\|WP_080045184.1\|11407805_11408945_-\|HAMP-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	1.46697e-76

>NZ_CP017717.1|WP_080045189.1|11413843_11414584_+|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MNLTLRVWRQSGPTDKGRMVTYKVEDVSPDMSFLEMLDVLNEKLILEGDDPIAFDHDCREGICGMCGMVINGVAHGEQRATTTCQLHMRHFEDGAEITIEPWRAAPFPVVKDLVVDRSAFDRIIQAGGFVSVPAGSAPDAHSVPVRKEDADAAFDAATCIGCGACVAACPNGSASLFTAAKITHLSLLPQGQPERLSRAKAMVDQMDAEGFGGCTNTGECTAVCPKGIPLDTIARMNSDYLKANAK
>NZ_CP017717.1|WP_080045188.1|11411924_11413847_+|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MKYTEGPEIRDTKAPSGPIEDRWEKRKFSAKLVNPANKRKLNVIVVGTGLAGGSAAATLGELGYNVKSFCYQDSPRRAHSIAAQGGINAAKNYRGDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQAVAQGVPFAREYGGLLDTRSFGGAQVSRTFYARGQTGQQLLLGAYQALERQVAAGTVEMHTRHEMLDLIVSDGRARGIIVRDMVTGEIERHLADAVVLATGGYGNVFFLSTNAKGCNTTAIWRAHERGAYFANPCYTQIHPTCIPVSGEYQSKLTLMSESLRNDGRVWVPLRKNDDRAPGDIPEDERDYYLERIYPSFGNLVPRDIASRAAKNVCDEGRGVGPGGLGVYLDFRDAINRLGRDAVEKKYGNLFEMYERITGENPYDVPMRIYPAVHYTMGGLWVDYDLQSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFVLPTTIGDYLANGPYGDVDEEAVAEAEIKVRTKIDRLLAVNGTRTPDSFHRELGKLMWDYCGMERTEESLRKALERIPELREEFWQNVKVSGTAEELNQVLEKAGRVADFFDLAELMCLDALVRTESCGGHFRAESQDADGEALRDDENFAHVSAWEYSPDGPILHKEPLEYEYVKMTQRSYK
>NZ_CP017717.1|WP_080045187.1|11411172_11411928_+|succinate-dehydrogenase-cytochrome-b-subunit
MTATIERGSATAPVNTPASKKTPTPKKQGGFLTSSNGKKVVMAVTGAVMVSFLVLHMLGNLKIFFGRESFNEYAHWLRTLLEPFVPYRTVLTILEIGLVVSVVLHMWAAISLSRRAGKARPVKYVAKKSQANGYATHIMRWGGVTIALFVIWHLLDLTFGVVNPAGYNSSPADRMIDGFDPSRWWVTLVYVVAVVMVGLHLRHGVWSAFQTLGWANKDRNKALRATAGLLSIVLVLGFLVPPLAITFGVVK
>NZ_CP017717.1|WP_080045186.1|11410110_11411040_-|LysR-family-transcriptional-regulator
MQFQQLAYFVAVAETRHFTQAAERMRVAQPSLSKQIKALEDDLGARLFSRARGNVTLTAAGEALLPLARRILADADTARQEVAQLAGLRRGRVRLGATPSLCAGLLADALARFHRAYPGIELLVEEGGSRDLVRALARGQLDLSLIIMPLQSDDPALVTEEILRENLVVVSPSHEQIKGPYLRIEELRGRPMVMFRRGYDLREATLAACRHAGFEPRFAVQGGEMDAVLRFVEAGLGVAVVPSMVLDGRPGLLGTPLAPPGLSRTIALAHRKDVEPTRAAQAFRETLLAFVVEAGHEGTLPQGVALIAE
>NZ_CP017717.1|WP_080045185.1|11408941_11410078_-|SpoIIE-family-protein-phosphatase
MTANLSETLTLLLIEDDDGDAFLVEELLKQAVAPPKIHRARSLREARAKLTPEIQCVLVDLSLPDASRLEALDEVLAVASPHTAVLVLTGLRDVHVGVSAVQSGAQDYLVKGDVDARLLARSIRYAMERKRADLAQLKLVQAELTAKENARLEGALLPDPLLRTSAIEHVTRYLPGSGGTLAGDFFDTVQTPDGAVHVVVGDVCGHGPDEAALGVALRIAWRTLVLAGQTGDPLLRTLDTLLRAERKAPEIFTTLCMATISPDLTSAGMRVVGHPPPVLVRDGVVEVVQGTPSGPPLGIFQDAAWSVLDVPLGEDWSMMLYTDGLIEAAVGEPARLLGVDGLVGLVREHGSIDLDRLITRVGTLSDDLAVVMLRRRRE
>NZ_CP017717.1|WP_080045184.1|11407805_11408945_-|HAMP-domain-containing-protein
MSIHPLPPPKAPTGLGRLPVAQWFVLLGVLAAVTFVAGVVIVLTMSTQAAALNPSPDLAAHLSRLNAALIVVFALLLGLGVGLVATVRYAVLKPIDQLTAQVRTVAGGDFDHDLHVDRPAELAELSSHIDSMRARIVSAWRVATDQAEELRRSNGELEQFAYVASHDLQEPLRKVASFTQMLEQRYGPQLDERARQYIHFAVDGAKRMQLLINDLLDFSRVGRVTGERSVVDSGAALDRALENLSATIEDAEATVTRDELPPVSGNELQLTQLFQNLIENAVKFRSEAPPRVHIGVRRDGDMWEFSCSDNGIGVEPKYADRIFLIFQRLHPRDVYPGTGIGLALCRKIVEYHGGQLWLDGEGGDGATFRWTLPMVGGEG
>NZ_CP017717.1|WP_080045183.1|11407368_11407809_-|response-regulator
MNGWRPIEVLLVEDDQGDILLTKEAFDLNKVRNRLNVVNDGEQAMAFLRQEEGFADAPRPDLILLDLNLPRMSGMEVLREVKADVMLRTIPVVILTTSEAEEDILHSYRLHANAYVSKPVDFEQFIRVVRQIDDFFVTVVKLPVQG
>NZ_CP017717.1|WP_080045182.1|11406380_11407166_-|hypothetical-protein
MTQTTPDAPVRRQRAQVKVRTLRTDRWWLVPLLTFLGLSSFLVYGIWAIIDNSYFVDPYIAPFASPCLATSCPEGARLFGWAPFGDWYALPPGLLILGLPGGFRLTCYYYRKSYYRSFWLSPPACAVQEPHGKYTGERRFPLILQNIHRYFFYAAIVIGLILAYDAVLALVHKPTGLGTWILVVNAVLINAYTLSCHSCRHITAGRLNHFSRHPLRYRAWTFVSKLNAKHQPLAWASMFSVMGADLYVRLVAKGIIAFPYA
>NZ_CP017717.1|WP_080045181.1|11404466_11406368_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MENTHNTERHEYDVVVIGAGGAGLRAAIEARQQGKRTAIVCKSLFGKAHTVMAEGGAAAAMGNVNPDDNWMVHFRDTMRGGKFLNNWRMAELHAKEAPDRVWELEAWGALFDRTKDGKISQRNFGGHEYPRLAHVGDRTGLELIRTLQQRVVALQQEDYENYGDYEAYIKVFAECTVTRLLKDGDAISGAFGYWRETGNFVLFDAPAVVLATGGIGKSYVVTSNSWEYTGDGHALALLAGANLINMEFIQFHPTGMVWPPSVRGILVTESVRGDGGVLRNSEGKRFMFDYIPEVFKDKYATTEEEGDRWYTDQANNRRPPELLPRDEVARAINAEVKAGRGSPQGGVFLDVSTRLPAEEIKKRLPSMHHQFKELADVDITAEPMQVGPTCHYIMGGVEVDADTGAAAVPGLFAAGEVSGGMHGSNRLGGNSLSDLLVFGRRAGAGAATYVDALKARPKVLPEQVDAAREEALAPLGRTGENPYEVHHELQRTMNDLVGIIRKAEEITEALGVVEKLKERVRMVGAGGSRIYNPGWHLAIDLRNMVLVSECVARAALMREESRGGHTRDDFPGMNPEWRRKLLVCSTEDGSTVKVEEKVQPPMRDDLITLFDRDELKKYLTDEEMAEFDGIAKS
>NZ_CP017717.1|WP_080045180.1|11403720_11404470_-|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MSYKAKFKVWRGEGGEGRLEDFTVEVNEGEVVLDIIHRLQATQAPDLAVRWNCKAGKCGSCSMEINGKPRLGCMTRMSTFSEDETITVTPMRTFPVIKDLVTDVSYNYQKAREVPSFTPPSGVQPGEYRMQQIDVERSQEFRKCIECFMCNNVCHVIRDHEENKTNFSGPRFLMRIAELDMHPYDVADRQEAAQEEHGLGYCNITKCCTEVCPEHIKITDNALIPMKERVVDRKYDPLVWLGNKIFRRK
>NZ_CP017717.1|WP_080045190.1|11414988_11415327_-|hypothetical-protein
MYVVITLLTATLVGLAAVANLARHSYGRAQAERQGVPVSWQVPLGFVLGAGAVGLLVGLAVPVLGTVSAACLVAYFTVAFIPEVRARPLRMGPWAVYFVLSVASLVTSLIAR
>NZ_CP017717.1|WP_080045191.1|11415476_11416946_+|ATP-binding-protein
MLDKPLRLYGRDAEWEELTDFVGSGSNGATLGLVYGRRRQGKTLMLELLAQETGGLIFAATQQTEAQNLADLGAAYARHLGLRRPVSFANWREGLDELLRLGEQRAVPVIIDEFPYLVSATPALPSYLQQALNPTGYAKEHTRTRLILCGSALTTMAQLLGGGAPLRGRAVLELVVRPFGFRDASAFWGLSEDPELAFRVNALVGGTPAYLEMSGGSGPAGIDDFDRWVQRRLLNPGSAMFREGGLLLREEPSISDPTSYAAVLAAISAGNHRRSEIAAALGRPVSALGHLLAALQSIGLVEHMEDALRQKRSVYKITEPIVRLHQLIIQRREPELVAGRAARVWDAGADTVASKIYGPHFEDLAREWCFLHASSDTLGGYASAVRPSELSCRAHRQGHELDIVVSETNASAPDRIIAIGEAKGTLSPMDVAQLQRLEHLRALLPDTQVEAPPKLLLFARAGFSDELARVARGRADVELVDLHRLYTGD
>NZ_CP017717.1|WP_080045192.1|11416869_11419266_+|AAA-family-ATPase
MSWRGWRVVVPTWSWWTCTGSTRATDPPSGVGGLRSHTLRPVKWSAVRRRRPKGLHSWKRFARGLRLLGQEGSSAAVVVLRLLSLRSRRPLDSHLPALFGCGHEAPHPGLRTDQPVPAKGARSSTGTFDDRTRYGSAAHGHQDQHRRARGTGGVFPTDDHPFRLNASAIFTHGVGGMAKGATNARPIGRDAELTLLADAVSGAADGALRAVAVRGDPGMGKTRLLAELAGLARARGFVVHHGQATEFERDVPFGVYIAAFEPQPGDPSRDAQRALTELLLDATGPSEARRAGLDRYRLFQRARRLIEDQGAAGPVAIVLDDLHWADQSSVELTEYLLRRPPRAPLLLATAYRTAQVPVGIARAVAQLGDATVDIGLSPLGESDVAALLPEADRGRRRLLYRTTRGNPLYLQVLANASVETLTALAEAGAAAGVDTRAGAGVGVDTRAGGEARAGVGGGDAAAGVPERALLDVLSTELTALTPQVRQVACAAAVAGEPISLDLVASITELPELALDHLVGVGLVVEADASFRFRHPLVRAAAYWMAGAAWRLRAHDRAAEQLRGSGGPLQLLAHHTARSAQHGDVRAVRTLEAAAAAASGAAPSTAVRLLRTALRLLPDETDPVLPDGTDLSPPDGTDLASWRVQLQWALGRALGVTGELAASRQILQEVMRAPGPLRIAAVSFSSMIYRLLGDLDEAKALLTTELTRPHARDRSTSLAQVGLAAVELMGSDPGKARRAAAVAIRSLTGAGGEALEGAGFRGTRRIRRWRRPLVPSTRWPVCVTAAWRRAGPRPTGRRG
>NZ_CP017717.1|WP_155129082.1|11419169_11420459_+|hypothetical-protein
MEAAARTIHALASLRDGRVAESRAETDRAAWLTDGMTDDVLAPHLEMVAPLAWVELHLRRHDDASRHLRRGLDIAYRAGRSHSVPYLLIALSALNERQGRLSEAITAAEEAREASRLIHSRETLAMSSILLLRPLLWRDGPRAALELAERISGTRPRSGWWSGLARLDLALVHAEAGQPDHALAILTSEDPADEPGRTYGLALQAIATATAAAPAAAAAWSEAGTLAERALARATESGLPHQLGFAHRARAKVLMLAGQDEEAVVHAARGAEQFAAAGAPVEEGLARQLAAELYAALGSVAQARGELGRAEVLVGQAREELGRAKVLYAAAGATWLSTALARDERRLAARVPRGQRRAAGPLSSLTTRERQIADLAVVGLTNQQIAERLYLSPKTVEAHLSRTFAKLGVQSRVTLTQHLTSDARATHDD
>NZ_CP017717.1|WP_155129085.1|11420656_11422354_+|hypothetical-protein
MSPLRGERPARARVVVTALCVALGLVLPAVPAGADPVPVPLPPRPTLQSPGPVTPAPGVPLPTLPPRPVPLPCPPTCLTDPDPYDAVVYGDSYTSGEGASHDHKYVTKADGTEDFRHRSGLAPFYVAWAALEMGRNPLRRMTLTSDTMESVIGRDRLFFQASSGAWIKHLDEEQKEKKGGTVVRNPPQAQDVPTMAKLVYFGLGGNDAGFADLVSTAATAYLFRPNGALMGSLTWPDDQEKSVALEMGRLQPRVAELKDKVARGLWSVRETHPVAEIVVALYPLGVKASGNTGIEEITGRTMDLMYPFAVQVNQAIRDGVAKFQADYPQTKVHIFDPNTAGPNGTSVVAGHELGQPDSYFQGLVHRPNLLLSKPFQSYQESFHPNEPGAVALGKALATFLAGKFPALFPNGPKFSALTMNPQPLAQTQEDMQAVLDWAVTNGPQLCEDTDADSVCRALTPDGIVLSKDLWFDPSKVRPFPGSPTPGGPDTGTPGGGGGGGGGGSTWIPADYIPKDPCDIFRPVRYEYYAGVKVQGGPLQTPITIDGLVMAPKKPKCVPGVGLIFE
>NZ_CP017717.1|WP_080047491.1|11422412_11422916_-|GNAT-family-N-acetyltransferase
MRMRNGTIDDLAPIVALHVESWRSAYAGMMPDTFLNGPLTEDRLVLWRDRLTSPVPGSALFVTHDDDDRLLGFAYLFPARDGRILLDNLHVRPGRTGSGVGSRLLRRGLAWAADEHPGKEVYLEVLRANTRAIAFYERHGARRTDERMCRFPQGFELAELEYAWTLN
>NZ_CP017717.1|WP_080045195.1|11422932_11424150_-|low-temperature-requirement-protein-A
MGLALFSLAVTGAAERHASWLELFFDLVVVVAVAQLAHRLEHPTWAGVGLFVLLYYAVWSIWTTLTLYSNVHAERTRTRSMLIGMFGIAVMAAAVPDVAHDGGLHEGWFIAAYITCRISASQTLQHSGTIMTAWPAAQLGAGLLPWLASIWADAPWRYALWGVGLVLDMVFSILQSRRPESLIEGLQRQARRHDERERRRQRPGRPPRPPREVAAAVLDPAHLGERLGLFVIIVLGEAVAQVVLSSSGKEWDAQLGLAALAGFGLIVALWWLTLQYGISTVVAARERELRAYVALPTHFVMTAGITATAAGLGVVAHEPDAHLHGGIGWVLGAGLAAYFAASTVLGATAGAERRWVWLWGVPSVIAPLGVAAVSGLLPAWVVIALLLVVALWRIAYRPRRSPAAA
>NZ_CP017717.1|WP_080047492.1|11424162_11425953_-|FtsX-like-permease-family-protein
MGSLLLVVRLVLADVRRHRTQAAMLLLAVTVATATLAMGLSLRGASDALYVQTRAATAGPDVVALSGDTGRAVTSALTGLADDPEVVAHHGPYQIVYADLTTRGSATSPVVVHGFDERPAAINRPLLTSGRWIRPGGTVLERGFATELGVKVGDRVTIEGRAYPVLGIAVTAATSIYPWAAQIGPGGGPSNYTGLAWMTRADARELAAAHDLPVTTAIDLKLKDPGATEAFREAHRFPAPRVNLHSWQFNAEQDARILRNSEPILIVGSWLLAFLAITGVAALATGRALEQTRRAGLLKAVGATPALIATVLLTEYLTLALAGEALGLAIARLAMPALASPTASRIGDLGGPGTGTVIATTVLALVVAVLSALRPTLRALRTATVTALSAAAHQPRRRPWLTALSALLPTPLLLGLRLTARHPGRAVLQAGSIATTVFAIATLLALFAEPVRGYGLNGSPALPNLRDAHDRRLLLAVTALLIVLALVNAITFTWTMAIEARTNVAIARALGATPGQVTAGLSAAQLLPAVPGAALGVLLHLGLRWLLTAGNAADAPVPWLLGAALATVLATAALTALPARLAARRPVARTLSAEAT
>NZ_CP017717.1|WP_080045196.1|11425960_11426701_-|ABC-transporter-ATP-binding-protein
MSESSAVIQVRGLVKEHGQGESRVRAVDEVDLEVPQGEMLAVMGPSGCGKSTLLHLLGGLERPTRGEVWVAGRRIDGLSERALARLRRRSVGFVFQAFHLVEELSAAENVELPALLAGGSPRQARRRAGVLLERVGLAARARHLPSQLSGGQRQRVAIARALVNEPLVVLADEPTGNLDSAASLEVLRIFEELRAAGQTLVIVTHDERVAAGADRLISMRDGMFVDDTRLAGATPRGLGDLLNLDG
>NZ_CP017717.1|WP_080045197.1|11426697_11427357_-|PadR-family-transcriptional-regulator
MQDAVLAMLAKEPSHGYGLRARLRQSLGPLGESMNPGQIYVTLARLEKAGLVVSERADGLPERPDRKIYALTPAGQQRVAAWLAEVGWPKPDLAEFHLKLVAASAARLADPVELVGAQRRELLRRLREAQHAILAEAAESKAVLLLEGVVLRLQADLRWLEACEQAWSRGADAFDRAWGEGEAGAQGGAKARGGAAAWDGVEGRFKAGGGRGDDRVEGV

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Crispr_ID: NZ_CP017717_35

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_35

11566878-11567129

Orphan

Consensus_repeat	Method
CCCGCGCTTCGCTCCCGCGCTTC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP017717_35

>merge|NZ_CP017717|35|11566878-11567129|CRISPRCasFinder
CCCGCGCTTCGCTCCCGCGCTTCGCTCCCGCGCTTCGCTCCCGCGCTTCGCTCCCGCGCTTCGCTCCCGCGCTCCCTTCGGCTCACTTCGCCGCCCGCTCGCCCGCCCTTCGCTTCGCCGCCTCCGCCACCCGCCTCGTTACCCGCCTCCCACACCCGGCCGTCTTACGCCGCCCGCCTTGCTCCGCCCCCTCGGTTCGCCCATCTCCCTTGCGCCACCCATCCCCCTACGCGCGCTTCGCCCTGCCCCTTT

>NZ_CP017717|35|31|11566878-11567129|CRISPRCasFinder
CCCGCGCTTCGCTCCCGCGCTTC	GCTCCCGCGCTTCGCT
CCCGCGCTTCGCTCCCGCGCTTC	GCTCCCGCGCTCCCTTCGGCTCACTTCGCCGCCCGCTCG
CCCGCCCTTCGCTTCGCCGCCTC	CGCCACCCGCCTCGTTACCCGCCTCCCACACCCGGCCGTCTTACGCCGCCC
GCCTTGCTCCGCCCCCTCGGTTC	GCCCATCTCCCTTGCGCCACCCATCCCCCTA
CGCGCGCTTCGCCCTGCCCCTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080045297.1\|11561431_11563480_+\|ATP-dependent-DNA-helicase-UvrD2	unknown	unknown	gnl\|CDD\|223288
NZ_CP017717.1\|WP_080045294.1\|11559075_11560047_+\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699
NZ_CP017717.1\|WP_080047513.1\|11575368_11575926_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239646
NZ_CP017717.1\|WP_080045298.1\|11563517_11564456_+\|acyl-CoA-thioesterase-II	unknown	unknown	gnl\|CDD\|224857
NZ_CP017717.1\|WP_080045299.1\|11564570_11564837_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155129117.1\|11566033_11566582_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045296.1\|11560375_11561260_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NZ_CP017717.1\|WP_080045307.1\|11575928_11577134_-\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|378392
NZ_CP017717.1\|WP_080045300.1\|11564968_11565238_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP017717.1\|WP_080045304.1\|11568402_11569737_-\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_CP017717.1\|WP_080047512.1\|11573190_11573622_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320703
NZ_CP017717.1\|WP_080045306.1\|11574350_11575337_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|377028
NZ_CP017717.1\|WP_080045305.1\|11573618_11574203_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274643
NZ_CP017717.1\|WP_080047514.1\|11577267_11578341_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187551
NZ_CP017717.1\|WP_080045292.1\|11556315_11557791_-\|siderophore-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226715
NZ_CP017717.1\|WP_080045308.1\|11578359_11578785_+\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|238385
NZ_CP017717.1\|WP_080045295.1\|11560053_11560302_-\|NrdH-redoxin	unknown	unknown	gnl\|CDD\|131255
NZ_CP017717.1\|WP_080045293.1\|11557787_11558927_-\|siderophore-biosynthesis-protein	unknown	unknown	gnl\|CDD\|235010
NZ_CP017717.1\|WP_155129120.1\|11567310_11567940_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP017717.1\|WP_080047511.1\|11572259_11573039_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235852

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080045297.1\|11561431_11563480_+\|ATP-dependent-DNA-helicase-UvrD2	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.33041e-97
NZ_CP017717.1\|WP_080045294.1\|11559075_11560047_+\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	5.38217e-81
NZ_CP017717.1\|WP_080047513.1\|11575368_11575926_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.24314e-33
NZ_CP017717.1\|WP_080045298.1\|11563517_11564456_+\|acyl-CoA-thioesterase-II	gnl\|CDD\|224857	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism].	9.07818e-126
NZ_CP017717.1\|WP_080047512.1\|11573190_11573622_+\|M48-family-metallopeptidase	gnl\|CDD\|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	1.58301e-26
NZ_CP017717.1\|WP_080045296.1\|11560375_11561260_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.19989e-22
NZ_CP017717.1\|WP_080045300.1\|11564968_11565238_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.70017e-13
NZ_CP017717.1\|WP_080045304.1\|11568402_11569737_-\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	9.15546e-91
NZ_CP017717.1\|WP_080045307.1\|11575928_11577134_-\|zinc-dependent-metalloprotease	gnl\|CDD\|378392	pfam10103, Zincin_2, Zincin-like metallopeptidase. This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family has similarity to Peptidase_M1 (pfam01433, Structure 3CMN).	7.12757e-161
NZ_CP017717.1\|WP_080045306.1\|11574350_11575337_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	7.86811e-22
NZ_CP017717.1\|WP_080045305.1\|11573618_11574203_+\|hypothetical-protein	gnl\|CDD\|274643	TIGR03552, F420_cofC, 2-phospho-L-lactate guanylyltransferase. Members of this protein family are the CofC enzyme of coenzyme F420 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.61155e-05
NZ_CP017717.1\|WP_080047514.1\|11577267_11578341_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.24044e-75
NZ_CP017717.1\|WP_080045292.1\|11556315_11557791_-\|siderophore-biosynthesis-protein	gnl\|CDD\|226715	COG4264, RhbC, Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism].	1.31847e-27
NZ_CP017717.1\|WP_080045308.1\|11578359_11578785_+\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|238385	cd00756, MoaE, MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.	2.49556e-49
NZ_CP017717.1\|WP_080045295.1\|11560053_11560302_-\|NrdH-redoxin	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	5.65224e-23
NZ_CP017717.1\|WP_080045293.1\|11557787_11558927_-\|siderophore-biosynthesis-protein	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	5.2098e-40
NZ_CP017717.1\|WP_155129120.1\|11567310_11567940_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	9.87976e-13
NZ_CP017717.1\|WP_080047511.1\|11572259_11573039_+\|enoyl-CoA-hydratase	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	7.98822e-66

>NZ_CP017717.1|WP_155129117.1|11566033_11566582_-|hypothetical-protein
MLLVVNAGRRGGLVPETAFTHAIAPFAALTGLLAITGIYLLIRERAGVLGLVGYVLNSAGLAGAFAVEYTLHFVFPYLGSGTVRGLLAGGTGRAFLVTSVVLLVGVLTFAVAAGRSGVMPVVGVVLYAVGMVPGSLRNLVPEPVYLGGLVAAGVGVAWMAVRLWAAAKAEAEKAPVMAVGQG
>NZ_CP017717.1|WP_080045300.1|11564968_11565238_+|WhiB-family-transcriptional-regulator
MGAKTIMDLIDEAKIPCRTDPDLWFAESPEDVEFAKALCGGCPIQKACLARALEREEPWGVWGGELILRGTIVPRKRPRGRPRKHPVAA
>NZ_CP017717.1|WP_080045299.1|11564570_11564837_+|hypothetical-protein
MISIQMSATQWLAFACRDSVRLADGPAKLRQEKSARSQAAAFSARAHVAVAAAPGAPVYMARIELPANQLTKGGLCGPQPWRDAPVIT
>NZ_CP017717.1|WP_080045298.1|11563517_11564456_+|acyl-CoA-thioesterase-II
MGDTSNLSQRPVWGTGDHGGDGHVNSALKELLDLLDLEQIELDIFRGRSPEERIQRVFGGQVAAQALVAAGRTVPKDRNVHSLHAYFIRPGDPSIPIVYNVERLRDGRSFTTRRVVAVQHGKAIFTMSASFHVFEEGVSHQASVMPSVPDPETLPTFQDRMYELVGDQPELREWFTRPRPVDARYASPLTWEAFQNPELRSAQTNVWFRYHAELPDDPLLHVVLAAYASDFTLVDTILLAHGMAWGASNVMGASLDHAMWFHRPFRADDWLLYAQESPWSAGARGLARGEMYTASGDLVVSVVQEAMIRLTK
>NZ_CP017717.1|WP_080045297.1|11561431_11563480_+|ATP-dependent-DNA-helicase-UvrD2
MNDADDVLTGLDPEQRAVAEAVRGPVCVLAGAGTGKTRAITHRIAYAVRSGVVDAQSVLAVTFTTRAAGELRQRLRALGAPGVQARTFHAAALRQLTFFWPRVIGGAAPSVIESKLPVLGEACRSLRLTPERSELRDIASEVEWAKVTQIGPEDYVAAATKYHRTPPIPAEQVSRVYEAYERIRRERHLVDFETILELTAAVMTEHQEVAAQIRQQYRYFVVDEYQDVNPLQKLLLDTWLGGRDDICVVGDPNQTIYSFTGASPRYLTGFGVEHPDAAVIKLVRDYRSTPQVVNLANLVIAKGRSPHRLELVAQRPDGPKPAFTEYDDEPAEAAGVARGIRKLLDKGVPAREIAVLFRVNSQSEAYEEALTKAEIPYVLRGAERFFERPEVRQAVVLLRGAARSAAGEPLASEVHHILSGIGLTPAPPGGGKAREKWESLKALADLAEDMAAEGADLPAFVAELERRASEQHAPPVEGVTLASLHAAKGLEWDAVFLVGVTDGMLPIIYAETPDQIEEERRLLYVGVTRAREHLSISWALARAPGGRKSRRPSRFLDGLTGRASAPPRMAPSASRERRQVATPVSCRVCAKTLVNATEQKLGRCSTCPADYDEALLERLKAWRTATAKETKVPPYVIFTDVTLQAIAERAPVTEQELLSIAGVGRVKLDRYGEAVLELCRGS
>NZ_CP017717.1|WP_080045296.1|11560375_11561260_-|alpha/beta-hydrolase
MSALALAAVALTPVAASASMEPTPAPTVDTPVDAEGIGGLSVETVQYGPHKRQSMDVWWTPDGQQRPGIFLIHGGWWSSGDKKYMKEITRGYAELGYTVFNLNYRLSGEAAWPAQRTDALTAIATARKHADRYAFDPNNYVLVGFSAGGHIAAAVGTYGDGIGGLKGVVGLSPIISPLRAYADGEKTTDANKRRLRSAAIKLAGGCPPKGKCSRVWASMEVAWHASRKDAPMLTIHSENEFVPPVQSELLKQMLGQVGVQVSVFTQPGTNHSSPLYREPGVAERVQAWIASRIG
>NZ_CP017717.1|WP_080045295.1|11560053_11560302_-|NrdH-redoxin
MALTVYSTTWCGPCKRLKAQLTREGISFDEIDIERDPSAAEFVMSVNNGNQVVPTVVIETPKGRVVRTNPSALEVKALLGAA
>NZ_CP017717.1|WP_080045294.1|11559075_11560047_+|NAD(+)-diphosphatase
METAEEQLIGPLLLARGTIDRSSALRADERWLERAWADPATKVLVIDDGHTLVRRSGDEVHAVLFPPADAPAGERYLLGVEDGVAYFAVAAPLPGLPRSEVNGRVTIPMSLRDTPEGEPVAAGLRQVGGLLGDRDAGLLVYAVALEAWHATHEFCPRCGTRTVVQAGGHIRVCPHDSSQHFPRVDPAVIMLVRDEADRCLLARGPQWPEGRLSILAGFVEPGESLEAAVVREVAEEVGIAVTNPRYLGSQPWPFPRSLMLGFFAEAVTTTLTPDAEEIAEAHWFSREELTRALESGELRLPPPVSIARRLIETWYGGELTGDW
>NZ_CP017717.1|WP_080045293.1|11557787_11558927_-|siderophore-biosynthesis-protein
MRLYLTALKPTDSVTDGFLPAARALGCEVTILTDRPDEHPSAVRCDVRDPRALIDTVEHLGRPDAIFSNSDHLQTETALAAAYFGLPGKDWRACAAAKNKFLMRRRLQEAGVEQVFSVRLGPLDPVPAEVPYPVVLKPREGVASEDVLLVESGLERAVAEVRRRRPGEALVVEEYLEGPLRTLETLGDAGGPRVLGGFRTTLGALPYFVEERLDWAPADESHEHVLVALRALGVGFGACHTEYVVTAAGPRIVEVNYRVIGDHCDFLLGDVLGVPIFEWILGVHLGASVPAVPEISRFGAAVSLVADRAGVIKDAPGPESVELGDVRLWHRPLRAVGEVVTLTHTNRDYLGVLRAVGPSPQRVDAAIEEYRAARPWVVG
>NZ_CP017717.1|WP_080045292.1|11556315_11557791_-|siderophore-biosynthesis-protein
MSGTSREAYLAARVLNALLREDYGGLAGRVTRTKDGVGLLLADGRWVRLSPGVLFQDFVVAADERIGLEQVLETLVEVAPPEDAEGVAAFFEECVAALTALELYDERAPEVKPSYEALAASVDHPVYPTSRARAGLSEAELLAYAPEFGGSFELRWAVVPGSSAHLPADVAPDWAREHAAADEALFPVHPLALDEVRKIDGVRVLERAGVRVRPTLSMRTVELGSRLHLKLPLPISTLGARNRRSIKPGTLEDGARAELLLRELADPDVVLADEQTYAHAGHEYLAWMVRRLPEGRIVPVAALTAPGVLDELGDVLPAYLRLLLRWNVRLFVRYGVALEAHQQNLALLFQGDRLKLLVKDNDGLLASPSRLRAAGVAVPEFADGRMLNDDPHALADVFVTITLHLASAAVAFGALPHDRAAALLRDTLADALGEYGGDPMARLLRARTLDAARLTGKSMITAGTLVSKERSGARDVNKFYGTSGPNYLRRA
>NZ_CP017717.1|WP_155129120.1|11567310_11567940_+|TetR-family-transcriptional-regulator
MPRAVSTSKELGALRQDLLDAAMRVLREQGAPYLTLRRVADAAATSTMGIYTCFGSRAGLLEAIYEHGFHLLHEAMTSSLNGHTDPRARIMAVAYGYRRFALTDPALYALMFERPLPDFDPSPEQRHEALHHCFGLLTEATAAAAQAGLIQSSNPQRSAYLIWTTIHGLVSIELTCSLRTPLPGWFLNSREEGERILTEGVQSLLGGLT
>NZ_CP017717.1|WP_080045304.1|11568402_11569737_-|AarF/ABC1/UbiB-kinase-family-protein
MSDLPRRAVTRSAKLATLPLGFAGRAALGLGKRIGGKSAEMVAQEVQQRTAEQVFKVLGELKGGAMKLGQALSIFEAALPQEIAGPYRATLTKLQEAAPPLPVSTVHKVLTEQLGDDWREHFLSFDDQPTAAASIGQVHKAVWHDGREVAVKIQYPGAGKALLGDFSQLARLGKLFGVLLPGLDMKSLLSELRERIAEELDYLREAEAQHAFALEFDEDPDFHVPDVVAANEMVLVTEWMEGTPLSRIISDGTKEERDHAGLLFVRFLFCSPARVGMLHADPHPGNFRMLPNGKLGILDFGAVNRLPDGYPKAFGQLTRIFNQGDMETVMAGLRQEGFIRQDIDIDPDALRAFLAPYVEPTAVEEFTFSREWLQAQAARVADLRPTNVVRQLNLPPSYVLIHRVHAAGVGVLCQLGTTARFRDEVIRWVPGFADDPDDQPLPIG
>NZ_CP017717.1|WP_080047511.1|11572259_11573039_+|enoyl-CoA-hydratase
MNELSVDRKDDGVVLITLNRPDLRNAMTDTMTAEWRATMTDLASDRDARCLVVTGAGTAFSSGGDLSWIGERGAEPVPRLRERMLAFYRTWLMITELEIPTVAAVNGPAVGAGLCVALACDLVYAADDAKLLAPFTSLGLHPGMAATYLLPRRAPALAREMLLTGRTVSGAEAADKGLVNQSFPKNDLMSEVAGIAAKIAQNAPIATRLTKVALNQDHQDLEAALRWESLAQPVTMASADMMEGLAAHRERRMPKFTGS
>NZ_CP017717.1|WP_080047512.1|11573190_11573622_+|M48-family-metallopeptidase
MLLPAWLSGEDADEWVSRMLDRLAAKERRRRPTDEALLERAKELSAKYLDGEPQPVSVRWVDNQQHRWGSCTPETGTIRISTRLKGLPEWVINYVIIHELVHLLVPSHGAKFWALVEQYPKAERARGFLEGFSAAAHTAPEEC
>NZ_CP017717.1|WP_080045305.1|11573618_11574203_+|hypothetical-protein
MTRIAAVLVRQHMAQAAPPGIDPDEFLEAMAEDTYEIVAGLELVTPVLVTSVPGLDEIVWPGTEVITIGEDEPLKDVLARLEGDQVAVVSADAPDLPPLLIGKLFRELGRAEITVCPAEGGGAVAMACALPAPAWAAPDLDAYDAVKDLRAQAPGPRRVATTPGWHRLRTPQDVERLDPGLEGWDNTRALVTAR
>NZ_CP017717.1|WP_080045306.1|11574350_11575337_-|endonuclease/exonuclease/phosphatase-family-protein
METSAVGGTIVTPVRKRRKFPATALTWAAVTPFAAWAVVRVAGLERGSLPTQLMTATPYAAAGSLIPLLIAAVGRRRAATAVALLSATALGFSVLPRALGTAEATAGRPFKVMTINMLFGRADIATIMKLVREFQPDVLSTQELTPGAVADLDAAGLKEIMPYRVLQDEWSAGGSGLYSRHPAQALWDVMPPVGHQMPAATISLPGGKAIEFIDAHPFPPLGPQVGDWNAALAAFPSASADRIRIIAGDFNASLDHAAMRGLLSRGYKDAADQVGAGLIPTWPANKRVPPLITIDHVLVDQRVGVREVSVRDVPGTDHRAVLAELTVP
>NZ_CP017717.1|WP_080047513.1|11575368_11575926_-|NUDIX-domain-containing-protein
MLHDDAVEVLSSWTAPTPEEEALRAEFLEHLRTHDDAMLRECVPGHLTATTAVLSHDGSKVLLTLHPKAKMWLPMGGHCEISDTSLAAAALREAWEESGISGLELLPGPLAVDKHAVWCHPPRSWHLDVEYAAVAPAGAEAVMSEESLDLRWFPVDEIPELSDEATRRLAARGQAALGSGSRMLG
>NZ_CP017717.1|WP_080045307.1|11575928_11577134_-|zinc-dependent-metalloprotease
MFGNPEQMAQAMRQFADMLSAPQGSGPVNWDMAKNIARHAVVAEGDPSVMEGERRQIVDALSLADLWLNEATTLPSGVSAPQAWSRSEWIENTIPIWRKLCEPIAERMVDTMGGALGGSGLPPEAQQMAGPLMGMLKQMGGMMVGQQIGQALGSLAREVIGTTDIGLPLSDTAALLPGGIAHFSDGLEIPADEIRLYLALREAAHHRLFQHVPWLRSHLLGAVEEYAKGITVDTSALEEQIRGLDINNPQAIQEALSGGNLLKPEETERQKAALARLETMLALVEGWVATVVDQAAQGKLPSAVALGETVRRRRATGGPAELTFGTLVGLELRPRRLREAAALWQALQNERGLDGRDALWGHPDLMPTADDLDDPDAFLRGDATWDISQLDEGPDDKGDEG
>NZ_CP017717.1|WP_080047514.1|11577267_11578341_+|NAD-dependent-epimerase/dehydratase-family-protein
MVPTSKRPRQPVVAVTGAASGLGREVLAKLVTSADFRRVVAIDEERGDVQEATWRVIDVRDPLLANRISDIDVLVHLAGDYAVDSDPAERRAYNLRAAQTVLTACAAARVRRVVLVTSAMVYGAAPDNEVPLPEDAPVAAEPDTGVVGDFLEIESLVRRSLRSHPGLEVTVLRPAAVVGPGVDTVITRHFESPRLLTVKGCSPHWQFCHIDDLVSALELAARGLVSGVVAVGCDGWLEQEQVEELSGIRSLELPAGLTFGTAQRLHRLGITPAPATDLHYVVYPWVVDCAALREAGWKPSWTNEAAFEQLLELRENRTTVVGRRLPVKEATLTAAGATVAVIGTAAIVRQVRKKRRG
>NZ_CP017717.1|WP_080045308.1|11578359_11578785_+|molybdenum-cofactor-biosynthesis-protein-MoaE
MDVIRLLGIRDTSLSVDEVLAAVADHAAGGTAFFVGTVREQDHGKPVTRLSYSAHPSAEAELRRVAEKVAADFPVTAVAAVHRVGELELGDIAVVVAVAAPHRGEAFEAARRLIDDLKAQVPIWKHQVFADGETEWVGAGE

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Crispr_ID: NZ_CP017717_36

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_36

11608030-11608165

Orphan

Consensus_repeat	Method
GCGTCGGCCTGGCTGGTCGTGCCCTGAGGTGCGCGAGCCTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_36

>merge|NZ_CP017717|36|11608030-11608165|CRISPRCasFinder
GCGTCGGCCTGGCTGGTCGTGCCCTGAGGTGCGCGAGCCTGAGTGGCTGTGCCTTGCGGTGGTACGCCGACCTGGGTGGTCGCGTTCTGCTGAGCGTCGGCCTGGGCGATCGCGTTCTGCTGGGCGTCGGCCTGGG

>NZ_CP017717|36|32|11608030-11608165|CRISPRCasFinder
GCGTCGGCCTGGCTGGTCGTGCCCTGAGGTGCGCGAGCCTGAG	TGGCTGTGCCTTGCGGTGGTACGCCGACCTGGGTGGTCGCGTTCTGCTGA
GCGTCGGCCTGGGCGATCGCGTTCTGCTGGGCGTCGGCCTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080045324.1\|11605164_11606019_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047518.1\|11606548_11607625_-\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|206747
NZ_CP017717.1\|WP_080045332.1\|11615414_11616770_+\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP017717.1\|WP_080045325.1\|11608564_11610094_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NZ_CP017717.1\|WP_080045334.1\|11618138_11618519_-\|thioesterase	unknown	unknown	gnl\|CDD\|227783
NZ_CP017717.1\|WP_080047517.1\|11604635_11605100_+\|DUF4442-domain-containing-protein	unknown	unknown	gnl\|CDD\|373120
NZ_CP017717.1\|WP_080045321.1\|11601166_11602000_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
NZ_CP017717.1\|WP_080045330.1\|11613939_11614206_+\|mycothiol-system-anti-sigma-R-factor	unknown	unknown	gnl\|CDD\|274904
NZ_CP017717.1\|WP_080045320.1\|11600347_11601133_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|225547
NZ_CP017717.1\|WP_080045319.1\|11599878_11600361_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_CP017717.1\|WP_080045322.1\|11602060_11603752_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379079
NZ_CP017717.1\|WP_080045323.1\|11603748_11604546_-\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|273949
NZ_CP017717.1\|WP_080045328.1\|11611851_11612184_+\|conjugal-transfer-protein-TraR	unknown	unknown	gnl\|CDD\|224648
NZ_CP017717.1\|WP_080045327.1\|11610948_11611695_+\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837
NZ_CP017717.1\|WP_043624264.1\|11613337_11613943_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|131992
NZ_CP017717.1\|WP_080045329.1\|11612360_11613104_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP017717.1\|WP_080045333.1\|11616766_11618062_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP017717.1\|WP_080045317.1\|11597658_11598639_-\|phosphate-ABC-transporter-permease-subunit-PstC	unknown	unknown	gnl\|CDD\|273992
NZ_CP017717.1\|WP_080045331.1\|11614248_11615190_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187566
NZ_CP017717.1\|WP_080045318.1\|11598645_11599758_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS	unknown	unknown	gnl\|CDD\|273374

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080047518.1\|11606548_11607625_-\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|206747	cd01854, YjeQ_EngC, Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases. YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.	1.35084e-93
NZ_CP017717.1\|WP_080045332.1\|11615414_11616770_+\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.27594e-66
NZ_CP017717.1\|WP_080045325.1\|11608564_11610094_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	4.94553e-102
NZ_CP017717.1\|WP_080045334.1\|11618138_11618519_-\|thioesterase	gnl\|CDD\|227783	COG5496, COG5496, Predicted thioesterase [General function prediction only].	2.31125e-23
NZ_CP017717.1\|WP_080047517.1\|11604635_11605100_+\|DUF4442-domain-containing-protein	gnl\|CDD\|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	8.91949e-25
NZ_CP017717.1\|WP_080045321.1\|11601166_11602000_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	5.76162e-14
NZ_CP017717.1\|WP_080045330.1\|11613939_11614206_+\|mycothiol-system-anti-sigma-R-factor	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	4.247e-27
NZ_CP017717.1\|WP_080045320.1\|11600347_11601133_+\|phosphotransferase	gnl\|CDD\|225547	COG3001, COG3001, Uncharacterized protein conserved in bacteria [Function unknown].	2.34678e-63
NZ_CP017717.1\|WP_080045319.1\|11599878_11600361_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	1.79171e-75
NZ_CP017717.1\|WP_080045322.1\|11602060_11603752_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	3.59242e-16
NZ_CP017717.1\|WP_080045323.1\|11603748_11604546_-\|histidinol-phosphatase	gnl\|CDD\|273949	TIGR02067, his_9_HisN, histidinol-phosphatase, inositol monophosphatase family. This subfamily belongs to the inositol monophosphatase family (pfam00459). The members of this family consist of no more than one per species and are found only in species in which histidine is synthesized de novo but no histidinol phosphatase can be found in either of the two described families (TIGR01261, TIGR01856). In at least one species, the member of this family is found near known histidine biosynthesis genes. The role as histidinol-phosphatase wsa first proven in Corynebacterium glutamicum. [Amino acid biosynthesis, Histidine family].	1.39031e-92
NZ_CP017717.1\|WP_080045328.1\|11611851_11612184_+\|conjugal-transfer-protein-TraR	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	5.9134e-15
NZ_CP017717.1\|WP_080045327.1\|11610948_11611695_+\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	2.88495e-111
NZ_CP017717.1\|WP_043624264.1\|11613337_11613943_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|131992	TIGR02947, putative_RNA_polymerase_sigma_factor, RNA polymerase sigma-70 factor, TIGR02947 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and (with the exception of a paralog in Thermobifida fusca YX) one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria and each gene examined is followed by an anti-sigma factor in an apparent operon.	2.34876e-112
NZ_CP017717.1\|WP_080045329.1\|11612360_11613104_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	6.05436e-09
NZ_CP017717.1\|WP_080045333.1\|11616766_11618062_+\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	3.68259e-17
NZ_CP017717.1\|WP_080045317.1\|11597658_11598639_-\|phosphate-ABC-transporter-permease-subunit-PstC	gnl\|CDD\|273992	TIGR02138, phosphate_transport_system_permease_protein_PstC, phosphate ABC transporter, permease protein PstC. The typical operon for the high affinity inorganic phosphate ABC transporter encodes an ATP-binding protein, a phosphate-binding protein, and two permease proteins. This family consists of one of the two permease proteins, PstC, which is homologous to PstA (TIGR00974). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions].	6.00653e-85
NZ_CP017717.1\|WP_080045331.1\|11614248_11615190_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.4532e-114
NZ_CP017717.1\|WP_080045318.1\|11598645_11599758_-\|phosphate-ABC-transporter-substrate-binding-protein-PstS	gnl\|CDD\|273374	TIGR00975, precursor_PBP-3_PstS-3_Antigen_Ag88., phosphate ABC transporter, phosphate-binding protein. This family represents one type of (periplasmic, in Gram-negative bacteria) phosphate-binding protein found in phosphate ABC (ATP-binding cassette) transporters. This protein is accompanied, generally in the same operon, by an ATP binding protein and (usually) two permease proteins. [Transport and binding proteins, Anions].	7.78058e-81

>NZ_CP017717.1|WP_080047518.1|11606548_11607625_-|ribosome-small-subunit-dependent-GTPase-A
MRKREYDEDDVRVRPGKGSRPRTRIRPAHEDAVEGFVVAVDRGRYTTLVEPERPKGSAQKRKPPQRRLVVAMKARELGRKGIVVGDRVALVGDVSGRPDTLARVVRVEPRTSMLRRSADDTDDTDGIERPVVANADQLVIVTALADPPPRPRMIDRILVAAFDAEIDTLLCLTKSDLAPPDELVALYEPLGVPHVVVHKGGSLDELRDHLAGRISVLVGHSGVGKSTLVNALVPDANRAVSHVNAVTGRGRHTSTSAVALELPDGGWIIDTPGVRSFGLAHVSVETVLAAFPDLVEGTVNCPKGCTHLDEGCALDAWVAAGNADPTRLESLRRLLSSREGTTDDPSAPRRDPTPDDTP
>NZ_CP017717.1|WP_080045324.1|11605164_11606019_+|hypothetical-protein
MNALMRAALAGAVIGLGQATLAVLAREHVNLLVFLAMLAGAFPAGGLLCWWGRLPLPWLISAVGSSGVMVYIPAIAIPFQDIVDLGEWGGRLVFMGLGVGAFTFAAALVVPMSRNVRLPVLGALLVLGLLAPLGRDSLTALAGMQVLARDGVPAVGLDAPGYRLTTFSAVEATLTLRYERQRDGAELVVSAEPRKWTEPQETCYNGGFHRSGPAPSGAGRVRCEKEPDGVWVRSDDKRYAVIAPHGAVTVEVFGDTASVAELRAAFATLRPLRWYEVVWLGGAD
>NZ_CP017717.1|WP_080047517.1|11604635_11605100_+|DUF4442-domain-containing-protein
MCGMSVDVGGLLLDTVPFARTLGIVFDTVADGHAVCHVPDRPDLHNHVAGPHAGVLFTLAESASGAAVLSALGDQLSRAVPLPTTATIAYRKVALGEVRAEARLLASREEVVARLDAGERPEFDVAVELTNADGTVVSTLTVTWTLRPNRPTSP
>NZ_CP017717.1|WP_080045323.1|11603748_11604546_-|histidinol-phosphatase
MQGYNDDLRLAHVMADAADDLTMRRFKAVDLKVETKPDLTPVSDADRAVEEAIRGTLRRARPRDAVVGEEFGKTGWGARSWIIDPIDGTKNYVRGVPVWATLIALMEYGKVVVGLVSAPALGRRWWAAAEGGAWTGKSLTKASRMHVSSVSTLEDASFSYSSFGGWEKRGKLDNFLDLSRACWRTRAYGDFWSHMMVAEGSVDLSAEPELSPWDMAALTVIVEEAGGVWTDTAGVRGLEGGSLVCTNGVLHDEVINRLNGTTIRS
>NZ_CP017717.1|WP_080045322.1|11602060_11603752_+|right-handed-parallel-beta-helix-repeat-containing-protein
MEFHVSPQGDDSWSGSAERPFLTLERARSAAREVPGEVVVRLRGGTHVLTRPFELAEPDSGTVYEAYGYGSAAQEEAVVSGGRPISGWQERDGVWRAEVGDLEVRQLYVDGRRAARAAVAGLPGAAEATATGYVTDSAEPRGWRSAEFVYRGVYPWSEARLGMAEAGADGDRTVITMAQPGFGWAVELYNSTWAGNTSRGPGLPTSIENEPGFLREPGTFVLDRSRPGEHVLLYLPLPGEDPARTTVVAPVLETLVRVAGAREVAFRGLVFAEATWLRPGRPEGFVHYHGSGYYEGGGVETAVLGEGASVTYPSSSVTIPACVTFDDTTGVVIEGCRFTRLGASGLGVSGGDRLTVRGCDFETISAGGVVVTGSRATTLEDNRVRRIGLEFSGSPGIAVTGTKGCVVANNEITQVPHCGIVAGPGEGTRILRNLTVDTMQVLADGGGVYLSGAQGEGAEVRGNMITDTRTPYNFGLYLDYGASGVVVEENVVARADNTAVLHVGPPLENVVFRGNFWDADPLGHDDVPGGVTYEGNVTIKDERELNAATADIRARAGLLTPRG
>NZ_CP017717.1|WP_080045321.1|11601166_11602000_-|TetR/AcrR-family-transcriptional-regulator
MPTSQDPVELLWRKEEPEPRPGLSVGRIVRAAIELADAEGLEGLSMRKVADRLGFTTMSLYRHVPGRDQLVDLMRDEVMGEHPELPPEREGWRARLEAIARQAWEIRRRHPWLAEVRGTRHLPGPHGVAHYDAMLATLTGTALRPSEVVAAIGLLGRFVDAEALVLVETRREEQRSGVSEQEWWGARDSLYERLDQYPALSHLWESGAWDAPEDSFEFGLRRLLDGIEALIQERDETRDETCQECGKPLEPTAPSGRPRVYCSRACQQRAYRKRKDG
>NZ_CP017717.1|WP_080045320.1|11600347_11601133_+|phosphotransferase
MRFTDDLGSSHGWRLRRGVLDDGREVFAKVGAASEMFASEAAGLRWLGEAAAVPEVIEVGPDRLVLSWVREERPSPAAAERFGRSLAGLHRAGAPGFGAPWPGFIAELPMDNAPCDGWPAFYGERRVLPFLRLARLPAADAALVERAVERFPEVAGPAEPPARIHGDLWSGNVLWSGGGGVLIDPAAHGGHRETDLAMLELFGLPYLDRVLGAYREEWPLAEGWRERVPLHQLHPLLVHVVLYGEGYRGSLMRAVRRVLAL
>NZ_CP017717.1|WP_080045319.1|11599878_11600361_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MTYRVCLVCMGNICRSPMAEVVLRRTLADRGLGGRVTVESAGTGGWHVGDPMDERALEILSQHGYDGSAHRARQFTKDWFDRYDLVLAMDRDNLSNLRRLAPAGVEVRLFRSFDPAAPEGAEVPDPYYGGREGFEEVLELVEAASEGVAKHIADELDEIH
>NZ_CP017717.1|WP_080045318.1|11598645_11599758_-|phosphate-ABC-transporter-substrate-binding-protein-PstS
MKYAGRLAAVAVVGALSLAACGTDNNSGAGSTSPASASAPAAGNDNGGLSGTINAAGSSAQANAITEWTKNFTATNPGVTLNYQPSGSGAGVQAFIQGTVSFAGSDSALKEDEPTQANARCKTGNAINIPMVTGPVAVVYNLPGVEGLQLSPKTLGGIFNSTITKWDDAAIKADNPDAKLPSTPIQAFHRSDESGTSDNFTKFLKATADWPYEPAKAWPAEAKGQGSKGSDGIASSVKDTEGAISYVELSYAENSSLQKAKVANGAGEFVELTPESAAKTVETAEIKGTGNDLALSIDYATKTAGAYPIVLVTYEITCEKGLPAEEAKVVKEFLKYTSSDEGQAALKELGYAPLAGTLLTKVRTAVEAIS
>NZ_CP017717.1|WP_080045317.1|11597658_11598639_-|phosphate-ABC-transporter-permease-subunit-PstC
MATNVRTRDGGPATSRSASRRSRGEAPFRYLSTAAGVALLAIMAAIAVFLISEAIPALQANKANFFTELTWEPNSSREFGIAALAFGTVLSSLLALVIATPVAVGVALFISHYAPRRLAAPLGYLIDLLAAVPSVVYGLWGVAFLVPLLRTPSQWLNENLGWFPLFAGEGIIGGKTMIAGAVVLAIMILPIIAAISREVFLQAPKMNEEAALALGATRWEMIRMAVLPFGRPGVISAAMLGLGRAMGETIAVALIFPATFDITFQILTPHANSIAANIANGFGEANDIGRGALIASGLVLFIITLLVNMAARFVINRRKEYARAGA
>NZ_CP017717.1|WP_080045325.1|11608564_11610094_-|3-phosphoshikimate-1-carboxyvinyltransferase
MPAPHWPAPTATTPVTAIVPLPGSKSVTNRALLLAALADGPGVVRQALRSRDADLMVAALRALGTTLTPMRETSAGVDWQVTPGPIRGGAHIDVGLAGTVMRFVPPVAALADGPVSFDGDPHARKRPMGPILDALRALGARIDNDALPFTISGPLAGGEVTLDASGSSQFVSGLLLAAARFEKGITIRHVGPPVPSLPHIEMTIEMLRAVGVRVDAGERDVWRVEPGPIAARDMTVEPDLSNAAPFLAAALVTGGTVTIPAWPLHTTQAGDALRDLLTTMGATVTRTPAHSTSPATTAAGVDATTAGSDPTATGSGATATGSGATAADLGTAAMGSGATATVSGTTTTGSGTTTTGSGTTTTGSGTTSTGPGTTDLVVTGTGHITGIDADLRDVGELTPTIAALAALASTPSRIRGVSHLRGHETDRLAALATEINRLGGDAEETDDGLIIRPRRLHGGTFHSYDDHRMATAGAVIGLAVPGVEVENIATTAKTLPEFVQMWTAMLEAR
>NZ_CP017717.1|WP_080045327.1|11610948_11611695_+|SOS-response-associated-peptidase
MCGRYASARKKHELLEEFEVEQDAEPDKELGADYNVAPTKNVYAVLSRVPKEAERAVRQLRVVKWGLVPAWAKDPSIGSRMINARAETLAEKPSFRQAFAKRRCLLPADGYFEWMPVEGEKKKKQPYFIHPSDGGVLAMAGLYEFWKDPSREDDDPLKWLVTCTVITTNAEDHLGRIHDRMPMMIERERWAEWLDPKLTDTEQAGRLLVPAESGRLTAYAVSTDVNNVRNNGPDLIKPLPEEEETALF
>NZ_CP017717.1|WP_080045328.1|11611851_11612184_+|conjugal-transfer-protein-TraR
MDVTTARERLEDMLAELDRSIGVLQGDPVAVREHSAADAGSDLTDADRAQAMLTVATAQRQAIMEALKRIDEGVYGRCVDCGSPVPEGRLEARPEAARCVQCQGKQERRR
>NZ_CP017717.1|WP_080045329.1|11612360_11613104_-|methyltransferase-domain-containing-protein
MLPIPAEELNGSGTLGPYWTFYRAVAAEQLNRWLPAEPSVILDLSGGRGKWSGQAARLGHRVVEVLDFRRTADGQSRLRDADRVRHVRADDLSFLPDASVDAVLAEERAMSIELMAESAMSDVARVLRPGGRALICVDSLVLGMAILAEQEQWQHLRQTGEVMLVPWPDGSITRCFSSGQLRELLVGAGLEVEWMRPRTVLSPSTVDHVLSSDARALNYLVRTELEAQPNDDDTVGIHLVASARRPG
>NZ_CP017717.1|WP_043624264.1|11613337_11613943_+|sigma-70-family-RNA-polymerase-sigma-factor
MGPVPATGAETLEQRSERFERDVMPYLEQLYSAALRMTRNPADAEDLLQETFAKAFASFHQFQQGTNLKAWLYRILTNTFINSYRKKQREPKQSGTEEIEDWQLARAESHTSSGLKSAEVEALEHLPDGDIKQALAALPEEFRIAVYLADVEGFPYKEIADIMGTPIGTVMSRLHRGRRQLRGLLEDYARERGLVPAEGSK
>NZ_CP017717.1|WP_080045330.1|11613939_11614206_+|mycothiol-system-anti-sigma-R-factor
MSCGNPHDTDCREVLDKVYSYLDGELTEGDVAEIRVHLDECSPCLKEYDLDKAVKALVHKHCGCDPVPADLRSKVLARIAQVRSELAD
>NZ_CP017717.1|WP_080045331.1|11614248_11615190_+|NAD-dependent-epimerase/dehydratase-family-protein
MRVLVTGGAGFIGSNLVDRLLADGHEVHVVDDLSSGSRDNLVEAARSDRFRLHEMDIRDPALVGLMAELQPEVVCHLAAQISVRKSVIDPAHDARLNVEGTAAVLNAAHEGRTRKVVFASSVAVYGRPATIPVPGDAATDPRSPYAASKLSGEIYLATFRALYGIEYTTLVLSNVYGPRQSPDGEAGVVAIFTDALLNGTPTVLYGDGTQTRDYVYVGDVVDGFVRACGGEGNGRRFNLGTGIQTTDRRLHSLIADAAGAQDKPGFAPPRVGDLPAMAVDPVPAHEGLGWQPRTDLSTGVKKTVEWAASRRAK
>NZ_CP017717.1|WP_080045332.1|11615414_11616770_+|HD-GYP-domain-containing-protein
MRDLPWPARVYLVAVIAAAAALVVRGVMVSGPPVATQDLDILLVLALLFLVCESMPTLLNVEQFAVSVSFSASLAAVVLLGPGGAALVGLTAVLSVRPGLPLIKRLFNGAQFAICGFVAGRVYEALDGRVGVPEVNAFDDLIGPYAAATAVFVPLNIALTLTMVGLATRVRATEVPMRGMAQFLLSYLGYGTFGLLVAGLWATVASISAVLVLLPLFVARWAFGQYHAQQRSYDATIAALCQAVETKDYYTRGHCTRVSHASSMIAQEIGMGVERVRAIRYAGMLHDVGKLGVPTKVLQKDGPLTEEEFAAIQLHPMRGLEIVRGIGFLDEAYAGIMHHHEKHDGTGYPMGLAGDEIPEFAKVIAVADAFDSMTSDRSYRGARPVPEAVEELRKSAGTHFDPVMVAAFIRALEREPWQPPRRADQPPPDAAEATIKDHDDPTMPIQVVTGS
>NZ_CP017717.1|WP_080045333.1|11616766_11618062_+|HD-domain-containing-protein
MITTERVRRTTGRSLSTVLRRLDSGQLLLICAAGLVALVGVAHTAAVGLTQPEIAVGFGALIAVGELARLTMPGNREVAPIGAAAALGYTLLLDLSQTPLEHPALQVVAVIAVGMTAGALPHLAVGRPPRLDAMARRLLTGALLAFAFRPLAAPLYEMTKPPTRTWWPALVVMVTLIAITLLIDVLIAALLRAEQVRTAFRVAVRDEINMAFPLGAAVASSGVLLALATHSMDLVALLVFAAPLLVTQVAFRKYAGIRATYLQTVRALSRVTEVGGYVEPGHSRRVSRLAVAIGRELGMAEPELLELEYAALMHDIGQLSLRDPIPGGATVLTEPEQARRIAELGAEVIRQTGVLDRVAEVVSRQCDPITDDPPLSSRIIKVANAYDDLVGPSTDRDRGGAALERIRLSSGSAYDPHAVEALARVIDRGRV
>NZ_CP017717.1|WP_080045334.1|11618138_11618519_-|thioesterase
MTLTPGLRAHLLIMVEMEDTAKRIGSGDVPVLATPRLLALAEAATVRAVEKHLAPGETSVGTRVELDHLAASPLGAHVQVSVELVEVDGRRLVFAFEAHEQSTVVGKGRIERVVVDRAKFLARATR

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Crispr_ID: NZ_CP017717_37

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_37

11643747-11643950

Orphan

Consensus_repeat	Method
AGACCACCTACACCTACGACACCCACGGCC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017717_37

>merge|NZ_CP017717|37|11643747-11643950|PILER-CR
AGACCACCTTCACCTACGACAACCTAGGGCGACTGGCGACGCAGACCGCGCCTGGAGTGAAGAACGAGATCACCGGCGTCACGCACACCGCGCAGACCAGCTACACCTACGATCCGGACGGCCACCGGCTCACCGAGACGGTCAAGGACCTGACCGGCGGCGACCCGGCCCGGACGACCACCTACACCTACGACGCCCACGGCC

>NZ_CP017717|37|3|11643747-11643950|PILER-CR
AGACCACCTTCACCTACGACAACCTAGGGCGACTGG	CGACGCAGACCGCGCCTGGAGTGAAGAACGAGATCACCGGCGTCACGCACACCGCGCAGACCAGCTACACCT
ACGATCCGGACGGCCACCGGCTCACCGAGACGGTCA	AGGACCTGACCGGCGGCGACCCGGCCCGGACGACCACCTACACCTA
CGACGCCCACGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080045361.1\|11656797_11657211_-\|transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP017717.1\|WP_155129132.1\|11650235_11650625_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045349.1\|11632127_11632460_+\|S24-family-peptidase	unknown	unknown	gnl\|CDD\|119397
NZ_CP017717.1\|WP_080045363.1\|11659742_11660867_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|237030
NZ_CP017717.1\|WP_080045358.1\|11651204_11652707_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045351.1\|11632998_11633745_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP017717.1\|WP_155129123.1\|11638722_11640393_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293791
NZ_CP017717.1\|WP_080045353.1\|11634572_11635427_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270342
NZ_CP017717.1\|WP_080045347.1\|11631071_11631509_-\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|235217
NZ_CP017717.1\|WP_080045350.1\|11632456_11632882_-\|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|378696
NZ_CP017717.1\|WP_155129129.1\|11648947_11649367_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045352.1\|11633741_11634569_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP017717.1\|WP_080045354.1\|11635690_11636902_+\|NADP-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|223358
NZ_CP017717.1\|WP_155129135.1\|11650646_11650877_+\|transposase	unknown	unknown	gnl\|CDD\|290319
NZ_CP017717.1\|WP_080045359.1\|11652882_11654391_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045360.1\|11654824_11656336_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045362.1\|11658380_11659544_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045364.1\|11661212_11662334_-\|serine-protease	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045348.1\|11631637_11632039_-\|superoxide-dismutase,-Ni	unknown	unknown	gnl\|CDD\|378114
NZ_CP017717.1\|WP_080045355.1\|11637229_11638588_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080045361.1\|11656797_11657211_-\|transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	9.7418e-27
NZ_CP017717.1\|WP_155129135.1\|11650646_11650877_+\|transposase	gnl\|CDD\|290319	pfam13586, DDE_Tnp_1_2, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	1.29333e-08
NZ_CP017717.1\|WP_080045349.1\|11632127_11632460_+\|S24-family-peptidase	gnl\|CDD\|119397	cd06529, S24_LexA-like, Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.	3.13282e-17
NZ_CP017717.1\|WP_080045363.1\|11659742_11660867_-\|trypsin-like-serine-protease	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00326794
NZ_CP017717.1\|WP_080045351.1\|11632998_11633745_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.88478e-153
NZ_CP017717.1\|WP_155129123.1\|11638722_11640393_+\|hypothetical-protein	gnl\|CDD\|293791	sd00039, 7WD40, WD40 repeats in seven bladed beta propellers. The WD40 repeat is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD dipeptides lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel beta-sheet. The WD40 sequence repeat originally described in literature forms the first three strands of one blade and the last strand in the next blade. The C-terminal WD40 repeat completes the blade structure of the N-terminal WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands, allowing them to bind either stably or reversibly.	8.29333e-07
NZ_CP017717.1\|WP_080045347.1\|11631071_11631509_-\|anti-sigma-factor	gnl\|CDD\|235217	PRK04069, PRK04069, serine-protein kinase RsbW; Provisional.	1.1094e-12
NZ_CP017717.1\|WP_080045350.1\|11632456_11632882_-\|CGNR-zinc-finger-domain-containing-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	2.09677e-13
NZ_CP017717.1\|WP_080045353.1\|11634572_11635427_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270342	cd13624, PBP2_Arg_Lys_His, Substrate binding domain of the arginine-, lysine-, histidine-binding protein ArtJ; the type 2 periplasmic binding protein fold. This group includes the periplasmic substrate-binding protein ArtJ of the ATP-binding cassette (ABC) transport system from the thermophilic bacterium Geobacillus stearothermophilus, which is specific for arginine, lysine, and histidine. ArtJ belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.08642e-66
NZ_CP017717.1\|WP_080045352.1\|11633741_11634569_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.00903e-57
NZ_CP017717.1\|WP_080045354.1\|11635690_11636902_+\|NADP-dependent-malic-enzyme	gnl\|CDD\|223358	COG0281, SfcA, Malic enzyme [Energy production and conversion].	2.34603e-177
NZ_CP017717.1\|WP_080045348.1\|11631637_11632039_-\|superoxide-dismutase,-Ni	gnl\|CDD\|378114	pfam09055, Sod_Ni, Nickel-containing superoxide dismutase. Nickel containing superoxide dismutase (NiSOD) is a metalloenzyme containing a hexameric assembly of right-handed 4-helix bundles of up-down-up-down topology with an N-terminal His-Cys-X-X-Pro-Cys-Gly-X-Tyr motif that chelates the active site Ni ions. NiSOD catalyzes the disproportionation of superoxide to peroxide and molecular oxygen through alternate oxidation and reduction of Ni, protecting cells from the toxic products of aerobic metabolism.	6.0937e-64

>NZ_CP017717.1|WP_155129123.1|11638722_11640393_+|hypothetical-protein
MRPLRLELTRRLAALSGVVAMTAGLITTLAPAAAADSTTDLGVSLSVTSKSGDVAVGGGKVFVSAENQIVVTDTAGVLSGAIAGLSGAQGLAMRPDGTRLYAALRGLNEVVEIDTATLAITRRIALPSNPCPSYLALSGDRLWVGYGCQHMYNGGVLGVDLSAAVPAPVEFGPNTSYAPILAAAGDTLVFGDPGVMPTDLLVYDVGGASPTSRGVISGSANGELSNLLDLAITGDGSKVVSSFGSPNRFDVWDTTSLTRTRTYGEESASHGSWRAVAISPDGEHVAGGSWRGSVDLTLFDTGTGATTYTTANPVGDVVQGSLAFSGDDVFSVLRASRDGRLHLWRAEDTTLSGSTLTLTPPDWSIVSKPLTMTGRLTLSGEPAPGPQQLVVTRRPDHGAATTLPAVTTAADGTFTFTDTSTAGGGTTWEVRWNGDSDHRAATASAFIWTRFPASLTLTGPAEGLVGSPLRLTGTLTTDGHAAAAGTWVSVQRTLTQDGNTVTTDLPGVATADDGSFAFTDTPAEAGRYRYVVQWGDTSFEPAEAGHEVTVQEDTGV
>NZ_CP017717.1|WP_080045355.1|11637229_11638588_+|hypothetical-protein
MEREPNRLLQQLIAEAGFSHKGLARRLNDLGAARGTPGLKYDHSSVLRWLGGQRPRDPVPCLLTEIFALRLGRPVSSEDLGMPAVITPLDLGQEFTHTWQEGVATVTALWRADVERRRFLIDSTFAIGAGSVGAVRWLTSPSEGRPSGTGTRRVGRADIAAIHEVTRSFGELDNRFGSGRVRSSVVKYLDTAVSPLLKDGTYGESTGRQLAAAAAELTRLAGWMAYDMEQHGLAQRYLIQALRLARGADDQTLGGEILAGMAHQAIYMGQPAHALDLARAAQMAARTAGVKTLLASAHVLEAHAHAGLGDPRACGHSLHEAECAFDARNPAEEPPWLSYFDEAYLSAKFAHCFRDLGEGERVVRQARRSLDMDSRYVRGRMFNLSLLAAGLLQCGELEEACSAAGHALTLAAELQSVRSRSYAADLRRRLEPYKNERAVAALRERTRELTAV
>NZ_CP017717.1|WP_080045354.1|11635690_11636902_+|NADP-dependent-malic-enzyme
MTTGVAVAATSASASAETPELDPAFALHKGGKIEIRSTVPVRDADDLSLAYTPGVARVCTAIADRPELADDYTWVSNVVAVVSDGTAVLGLGDIGPAAAMPVMEGKALLFKEFAGVDAVPLCLDCTDVDALVETVVRLAPSFGGINLEDISAPRCFEVEDRLRSLLDIPVFHDDQHGTAIVALAALQNAARLTGRALGDLRAVVAGAGASGVAVTRILLEAGIGDIAVSDSKGMLYEGRDGLNPVKQALARDTNRAGHTGSTEEALEGADVFLGLSGSTVSEAAIASMAPDAIVFALSNPTPEVHPEVAAKHVRVVATGRSDFPNQINNVLAFPGVFRGALDVRATAITENMKVAAANALAGVVRDELSETYIIPSPFDERVAPAVTAAVAAQARVDGVARAK
>NZ_CP017717.1|WP_080045353.1|11634572_11635427_-|amino-acid-ABC-transporter-substrate-binding-protein
MALRPLSRRGYAAGALALATALTLTACGSDSGSGTGTTSASASAAGGVKLVQPGKLTVCTNIPYEPFQFKDASGKIVGFDVDIVDLAAKKLGVTQNIVDIDFAVIKSGAAMAAGKCDVAAAGMTITDERKQNIDFSDPYFDATQALLAKKGTGAASLADVKSKGLKLGAQASTTGLDYVKKQGFNPTEYADSAKELLALQAGQADVIVQDLPVVLTWLKKPDIAAKFEMIGSLDTGEQYGIGLKKGADPVLLKTINEEIAKAKQDGTYEKIYVKWFGKKPGELG
>NZ_CP017717.1|WP_080045352.1|11633741_11634569_-|amino-acid-ABC-transporter-permease
MADQPKTAEPGRARLSPRKKQQVSRTIQYVVLIAALVAVVLYADWASLAQNFAKPDVARQALPDLFTIALRNTIIYTVGGFVFSFVLGLLLALMRLSQVRPYRWIAVVYIEIFRGLPALLIFLMITFLPLALPGFAVPFGTYGQGILGLGLVGAAYQAEVFRAGLQAVPKGQTEAARSLGMSATRAQVTVVIPQAIRMVIPPTTNQFVALLKDSSLVLFLGVSGEYVELAKFGNDLASQYANATPIMVAGVTYLIVTIPLGYLASRLEGRKGRNR
>NZ_CP017717.1|WP_080045351.1|11632998_11633745_-|amino-acid-ABC-transporter-ATP-binding-protein
MTVHAIELRDLHKYFGKNEVLKGIDMTVEQGQVVCVIGPSGSGKSTLLRCVNLLEAPTRGKVFVEGVEVTDPDVDIDAVRRRIGMVFQQFNLFPHMTALQNVMIAQQRVLKRSKREAEVVARDNLDKVGVGAKCDSLPGQLSGGQQQRVAIARALAMNPSLMLFDEPTSALDPELVGDVLTVMRKLAEEGMTMLVVTHEMGFARQVADRVVFMDGGVIVEDGAPAQVIGDPRHERTRAFLHRVLHPEE
>NZ_CP017717.1|WP_080045350.1|11632456_11632882_-|CGNR-zinc-finger-domain-containing-protein
MDLTSYAEWAVRLANDPDPPPELRGLRDELAAVFDAAGDDRAVAGLLNALLARYPVRPQLSDHDGRGWHLHLAEDPAATAVMGLAAVVAELGVDRLGRCREPHCGLAFLDTSSNRSRRYCSARCASRANVAAFRARRRNGA
>NZ_CP017717.1|WP_080045349.1|11632127_11632460_+|S24-family-peptidase
MRVRVEGDSMRPALVPGDWLLVRRGAAVHPGDLVVARLPGDPDRLIVKRAQWHGADGWWLESDNQRASGRRDSWDFGPVHDIVGRVVLRYWPLVRRSARKSSGGSSGKRR
>NZ_CP017717.1|WP_080045348.1|11631637_11632039_-|superoxide-dismutase,-Ni
MLARLLRPKHVASAHCDLPCGVYDPAQARIEAESVKAIMEKYAANEDPVFRARAIKIKEERAELVKHHLWVLWTDYFKPPHLEQYPQLHQLFWDATKLAGAAGAKGTVDVAKAEDLLGKIDEISKIFWETKAA
>NZ_CP017717.1|WP_080045347.1|11631071_11631509_-|anti-sigma-factor
MTEETETRAEGVAGIRDVVSIRLPAASAYLSVLRTATAGLAARLDFTLDEIEDLRIAVDEACAMLLNEAVPGTDLTAEFELTGQEMQVRVEVATVGSSAPKRDDFAWMVLTALADDVDAVTDSPDRMAIVLRKRRGAARGTAGPA
>NZ_CP017717.1|WP_155129129.1|11648947_11649367_-|hypothetical-protein
MLHPERIIEYPSLEELPEQLQQPLSEWDDEADFAYSDLLSVATGCKIGGWVSWGLTDMYKLACEVCGAETELLLKFASSEWEDDGEQRWRPLEERRILRGTPEYAQIHEPTTLQLGRDASLYIFVCPQSADHGYRLSIQ
>NZ_CP017717.1|WP_155129132.1|11650235_11650625_+|hypothetical-protein
MIHHYWRTWCIEGRWEQILARLCEHERVGGGSDPTPSTGSIVPERAAHQLGRTARLRRRQKIPRVKRHLLVNALGTVVTACVSPVSVNDRDGAAVPTRTDDLLRRLKHPWAIKAIAARSSSGEFWISSV
>NZ_CP017717.1|WP_155129135.1|11650646_11650877_+|transposase
MTAGSATLGPRSGVRRGRSSVLARNHRWVVERTFAWLGKYRRLAKDYEYLAATSENVVYLAMITPRTFQPAGQSLR
>NZ_CP017717.1|WP_080045358.1|11651204_11652707_-|hypothetical-protein
MKRLLIPLAAAGLSAAVLASPATAAPSWASEDLLPKPADAYGAAAFWLDSNGAALRKATQYNLDAKDVPKIVSSGGKGAPDGKPGMTGPTTTAKATTSKNVNLPKTVGKVFFLDKAGHYRWCSATSIQSRNHNLVATAGHCVFENGKDEVYNKWIFVPGYYQGKAPWGVYVGAYAFTAYDLDTYDDYDGDYAFVAVHNGFSLSGSKQVSKADYDKWLGDKWAKDVEITQAEYTKCVDLNGGESPDCWAKLATNADVVGPDYTGEKKRAFKEVSKEEYDKAPTGNGNGAQEPTKTVVDYVTKSEYDAYKGEGYRKIDANGNFTITHYFLGYWVKESTKTLYYKTVFTVGIAKDLGRLGDVVGGQGLAWNQPLGQQVTVFGYPSAPHPDGDRPFTGVTPKWCTGKTGTKSVQVNTFKVETHQTLKCSMTFGADGGPWLIKYNNSKRTGYVNGVTSLFADTDGNDRIDTISSAIFDSETADVYNKANYAETKKIVGPNGELLK
>NZ_CP017717.1|WP_080045359.1|11652882_11654391_-|hypothetical-protein
MKRILLPAGGALLATGLLAAGLASTAQADDKIADADLAKTAAQAAEVLDFWTKSDNAALKKAVAFNPDALEVEKISSGGGYSADTKPGSTAPIGEEKKSTAKVQNVNLPKTIGKVFFEYRDGSLYWCSGTSIQSQYRNLVATAGHCVYDIAGNDEVVSRWVFVPGYYQGKAPWGVYVGKQAFTHYDFDVYEDFDRDYAFVTVYDGIGGTLNKPKQVSKADYDKYQGEKFTKDYSITEAEYKKCKDLNGGETPDCWAKSADLEDLAGPDTPGAEKVLKEVSKEQYDAAPTGDKNGAKAEGATTIDYVTEAQYKAYSGPGYRKIDDKGNFTITHYYLKYWVKKSSEVKYFRTEFFIVVHEVKSVGRLGDNVGGQGFAWNQPTGKYVRTFGYPFGPHLDGNKPFTGVTPKWCYGKTAKNVLRIPSKKVEEQISFKCTVTAGYDGAPWLYKYSNSKRLGYVNGVTSLIADTDSNKRYDTITSPYFDGETAAIYKAASASWSGKLIP
>NZ_CP017717.1|WP_080045360.1|11654824_11656336_-|hypothetical-protein
MKRILIPAGGALLATGLLAAGLAGTAAADSDVAKDNLATSAANAKAIADFWAENNGAALKAATESNIWDKSDVAKLQSKGGYSSDTKPGSTAPIGEEKKTSSKVQNVNMPKTIGKVFFVNSKGEKKWCSATSIQSQYRNLVATAGHCVYDTGANSDVMSKWVFVPGYYQGKAPWGIYVGKQAFTHYDFDVYEDYDRDYAFVTVYNGVKVDGGGKTKQVSKAEWDKYAGIKDAKDQEISQAEYQKCVDYNGGETPDCWAKASDLEDLVGPDYPDATKVLKEVSKEQYDAAPTGKKNGAKAEQATVTEFVTESQYKAYKGPGYQKIDDKGNFTITHYFLKYWVKKSTSVKYYKTTFFIVETGSLDAGRLGDNVGGQGFAWNQPTGKAVRVFGYPAAPHPDGNKNYTGVTPKWCYGNTTKKLVGSAAKKIEEHVALKCAMTEGADGGPWLYKYSNSKRLGYVNGVTSTFNDQDSNGRVDYISSPYFDGETNTVYKAAAASWSGKVV
>NZ_CP017717.1|WP_080045361.1|11656797_11657211_-|transposase
MRRDDLTDAEWEQVAPLIPHDSVHADRTDDRTVINGLLYQARTGVRWRYLPDRYGCWVTIYKRHRRWLADGTWHRLALALRTDGAKTIRAGHADLDLIRSHPPGSPGTAPDLSPFKDTAVLASLQALLGDTVRAKKL
>NZ_CP017717.1|WP_080045362.1|11658380_11659544_-|hypothetical-protein
MKRILLPAGGALLATGLLAAGLSGTAQADGDVAHDPMARNNSDAVSIASFWLASNGAALRSATQYTWDSNEVRKVVSKGGYSPDGRPGTTAPTGSSKSTGSAQNVNLPKTVGKVFFVDGQGKFRWCSGTSIQSNYRNLVATAGHCVYDTDSNSATMDKWVFVPGYYQGKAPWGIYVGKQAFTHYDFDTYEDYDRDYAFVTVFNGITSNGVKQVDRKDFERFTGPKRAWGGHYYILLSKDAGRLGDNVGGQGFAWNQPTGKPVRAFGYPAAPHPDGNKPYSGVTPKHCYGNTTAKAVGASWLKIEEHIGLKCAVTPGYDGGPWLLNYSNAKRLGYVNGVTSTFADQDGNDRIDYITSPYFDGETASVYNAAKNVWSGKIVGPNGELYK
>NZ_CP017717.1|WP_080045363.1|11659742_11660867_-|trypsin-like-serine-protease
MIPRARHFVAAALGSALLIVPAFTGIAHAATSAVASKVYAVPLARTLADVKRVADYWKPDRLKQTDLYTPATPGSGAGSTTSSGAAAGPAAPAAAGVTATAAKRTNAAAAVAPALPRQGTAANTMGKVFFRFGDKEFWCSAAAVAARNRSVVATAGHCAYDSRTGKPADYWIFVPNPGPNGGAPDGIYVGASISLHEDWSGKGDYDYDYAFVTVHRGFTWVAGKDGASVMQDVGRLQDNVGGLGLELNKKPGTYTVTAFGYPAGQQPDGTHPFDGKTLLKCLPGTTRYTVAPGRDLQKGVELTPCDFSPGASGGPWVIAYDSTRRLGSLAGVNSLTWNRDAKGRYDSVSAPYFDTTTGEVYRRAASLSTIPNVT
>NZ_CP017717.1|WP_080045364.1|11661212_11662334_-|serine-protease
MNPRARRIAFPLAGLLAIGLAAGMVSGAADATTAPSDVIARNSATPAEQAVQFWTPDRVKQATDHDEGIDVTSKGVKGSNDAPDGPPGSVPPIGGEKTSSKRSKHVNLPNTVGRVFFTLPKADPRDPRNWRYCSATSVQSKYRNLVATSAHCVYDTKQNTFYDNWIFIPSYWDGDKVWNGKAPYGIYAAKTFNAHDDFVVKEDYDYDYAFVNVFNGIKVDWQKAGNRWRWTVKNVGRLGDNVGGQGFTWNRSTKLNVFSFGYPAGEHPDGDRPYTGRTMKYCYGKTKAMPEAKKYNLQEHVGFKCSFTAGASGGPFLYNYKSASRTGYLVGVNSVAWDTDGNDRYDHISSPYFNTDTYKVYKAAANRWTGNWR

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Crispr_ID: NZ_CP017717_38

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_38

11793327-11793457

Orphan

Consensus_repeat	Method
GGGGCGCTTCGCGCGTGGGGGTTCGGGCTGTGACATTGGGGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_38

>merge|NZ_CP017717|38|11793327-11793457|CRISPRCasFinder
GGGGCGCTTCGCGCGTGGGGGTTCGGGCTGTGACATTGGGGGGCACCGCCCCCCAAACCCCCAGCTCCACAAGCATGGTCCTCCCGTGGGGCGCTTCGCGCATGGGGGTTCGGGCTGTGACATTGGGGGGC

>NZ_CP017717|38|33|11793327-11793457|CRISPRCasFinder
GGGGCGCTTCGCGCGTGGGGGTTCGGGCTGTGACATTGGGGGGC	ACCGCCCCCCAAACCCCCAGCTCCACAAGCATGGTCCTCCCGT
GGGGCGCTTCGCGCATGGGGGTTCGGGCTGTGACATTGGGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080045455.1\|11781505_11781877_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155129163.1\|11795776_11796172_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155130135.1\|11800287_11800989_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP017717.1\|WP_155129166.1\|11801018_11801783_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045463.1\|11792262_11793216_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP017717.1\|WP_080045465.1\|11793981_11794416_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045464.1\|11793622_11793982_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380412
NZ_CP017717.1\|WP_080045461.1\|11790039_11791248_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080045456.1\|11781867_11783079_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045468.1\|11797282_11798044_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NZ_CP017717.1\|WP_080045460.1\|11788195_11790004_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080045469.1\|11798159_11798777_+\|deaminase	unknown	unknown	gnl\|CDD\|334719
NZ_CP017717.1\|WP_080045459.1\|11786160_11788179_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP017717.1\|WP_080045457.1\|11783910_11785470_+\|flavin-monoamine-oxidase-family-protein	unknown	unknown	gnl\|CDD\|224152
NZ_CP017717.1\|WP_080045470.1\|11798827_11800291_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP017717.1\|WP_080045462.1\|11791462_11792242_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NZ_CP017717.1\|WP_080045458.1\|11785531_11786044_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240137
NZ_CP017717.1\|WP_080045467.1\|11796168_11797011_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP017717.1\|WP_080047530.1\|11783075_11783918_+\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|377424
NZ_CP017717.1\|WP_080047531.1\|11794767_11795550_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_155130135.1\|11800287_11800989_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.28959e-84
NZ_CP017717.1\|WP_080045463.1\|11792262_11793216_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.15691e-108
NZ_CP017717.1\|WP_080045467.1\|11796168_11797011_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	2.00084e-59
NZ_CP017717.1\|WP_080045461.1\|11790039_11791248_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.89502e-82
NZ_CP017717.1\|WP_080045468.1\|11797282_11798044_+\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	9.86798e-87
NZ_CP017717.1\|WP_080045460.1\|11788195_11790004_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.65415e-78
NZ_CP017717.1\|WP_080045469.1\|11798159_11798777_+\|deaminase	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	4.62657e-25
NZ_CP017717.1\|WP_080045459.1\|11786160_11788179_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.50576e-83
NZ_CP017717.1\|WP_080045457.1\|11783910_11785470_+\|flavin-monoamine-oxidase-family-protein	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	6.72418e-79
NZ_CP017717.1\|WP_080045470.1\|11798827_11800291_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.70076e-63
NZ_CP017717.1\|WP_080047531.1\|11794767_11795550_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.31865e-26
NZ_CP017717.1\|WP_080045458.1\|11785531_11786044_+\|hypothetical-protein	gnl\|CDD\|240137	cd04939, PA2301, PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, and ProX. The primary function of INS is to hydrolyze mischarged cysteinyl-tRNA(Pro)'s, thus helping ensure the fidelity of translation. Organisms whose ProRS lacks the INS domain express a single-domain INS homolog such as YbaK, ProX, or PrdX which supplies the function of INS in trans.	2.81812e-72
NZ_CP017717.1\|WP_080045464.1\|11793622_11793982_-\|hypothetical-protein	gnl\|CDD\|380412	cd07009, cupin_BLL0285-like, Bradyrhizobium japonicum BLL0285 and related proteins, cupin domain. This family includes bacterial proteins homologous to BLL0285, a Bradyrhizobium japonicum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.18951e-11
NZ_CP017717.1\|WP_080047530.1\|11783075_11783918_+\|M55-family-metallopeptidase	gnl\|CDD\|377424	pfam04951, Peptidase_M55, D-aminopeptidase. Bacillus subtilis DppA is a binuclear zinc-dependent, D-specific aminopeptidase. The structure reveals that DppA is a new example of a 'self-compartmentalising protease', a family of proteolytic complexes. Proteasomes are the most extensively studied representatives of this family. The DppA enzyme is composed of identical 30 kDa subunits organized in a decamer with 52 point-group symmetry. A 20 A wide channel runs through the complex, giving access to a central chamber holding the active sites. The structure shows DppA to be a prototype of a new family of metalloaminopeptidases characterized by the SXDXEG key sequence. The only known substrates are D-ala-D-ala and D-ala-gly-gly.	8.77954e-121
NZ_CP017717.1\|WP_080045462.1\|11791462_11792242_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	3.74734e-91

>NZ_CP017717.1|WP_080045463.1|11792262_11793216_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSEILVLVDHAEGEVKKVTLELLTLARTLGTPAAVWAGPGITADAKARLAEYGAEKIYVAGADDIVEYVVAPKAELLAQLVAAKSPAAVLVAATAEGKEVAGRLAIKTDSGVITDAVGLGEGFVADQSIFGGGINVHSRVRKGTPIVAVRPNSTAPVAAAGAGTEEEITVTLSDAAKAARVVERVKQEKGARPELTEAAIVVSGGRGVGSAENFSVIEGLADALGAAVGASRAATDAGWYPHQFQVGQTGKTVSPQLYIAAGISGAIQHRAGMQTAKTIVAINKDPEAPIFELADYGVVGDLHQVVPQLTEEINKRK
>NZ_CP017717.1|WP_080045462.1|11791462_11792242_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNIVVCVKQVPDTATERKLRSDDNTLDRDAADGVVNELDEYAVEEALKLKEAHGGEVTVLTMGPGKATDTIRKALAMGADKAVHLSDDALHGSDALSTSYAMAQVLKKIGFDLVILGSESTDARTGVLAAMLAERLGTAQLTLANKVEVEGSSIRIQRLTDYGFDRVEATLPAVVSVVEKINEPRYPSFKGIMAAKKKPVETLAIGDASIDAGQVGLAAAWSEVVDFAAAPPRAAGTIVKDEGDGGAKAADFLASKKFI
>NZ_CP017717.1|WP_080045461.1|11790039_11791248_+|serine/threonine-protein-kinase
MSERLGPYELLSRLGAGGFGEVHLALDPEGRTVAVKVLHPHVAADGGALARLAREVETMRMVGGPHVAEVLDASLTGGRPYLVTRYVQGRPLSSVPLPVADLRRLASGLADALHAMHEAGVVHRDLKPANVMMTEGEPVVIDFGIASALDSLSVTASGAVVGTPGYLAPEVLEGRAVGTEADVFAFGATMAYAATGRHPYGQGPASAVAYRVVHHPPDLEGVPEWLEPLLRECLDTDPAARPTAAQLCARLGVAPVPRAAPRPAPRVRPASDDVSTREWRPGKERHRRSVEESRARHREKVRRRWLIGSGLFVSLLAAAAREPLPEVSLFLLAAYALGVVSDAGVAMFSRGLYRRGRIVADAVSVAGAVGLCFGLAALFSTFTLALFAGTALVVGIVFLLSA
>NZ_CP017717.1|WP_080045460.1|11788195_11790004_+|serine/threonine-protein-kinase
MSTQAPERLGPYRLVRKIGEGGMGVVHLGLDGEGREVAIKVLHPHVAADLKARDRLTREVETMRRVRSPFVAEVIDAELVGSQPYVVTRFAPGRTLEDTVLSEGPLEARQVIQLTQGLCQALVAIHAADVIHRDFKPSNVMLVDGRPLVIDFGIAHLVNATRLTQTGMFVGTPGYLAPEIIRDSEITQAADVHALASTVFFAATGAPPFGTGTFESVCFNIMEGRAQIDKAPAWLRGWLTRALQVEPSLRPGAQELLRLAKALDPAVTTFNEGPTGTKRIVPRTRTMDTFSDLLPPVEYGQAAPPPPAPSPTPTRQEERPARREERPPPYVPAPMPARPAPHPDQRVAGHPPPDRRLVPKPTAPSQVRPYTPPPQYTPPSERKRYLFGSQVVGLLLLVTLVAVTVMMPVMAGAVAVALALVLRLGEYLFGDLVKRRQTRGSSAADPLLALVGTPWALVKSALVTAVHVPLSLLFGVCVWGVLYWAGKMGVNEAAAYAAGAFAAGLFVLPGGGAPRKAVTRTLTGVLRSPGAALVAVVLVGTAALFAVMFALGQDPTWAPWRAPESVINDLASDARQSTIGLITGLIGDLLDRLGLGWLNPWS
>NZ_CP017717.1|WP_080045459.1|11786160_11788179_+|serine/threonine-protein-kinase
MVLHAMNDDRLGPYRLLRRLGEGGMGVVHLAVDPQGRQVAIKVLRGEVAGDEVARRRLSREVETMRRVRSKYIAEVLDADVTGHRPYIVTRYVAGPPLDEIVKNDGPLDLPALLRVAHGVAAALAVVHSVGVIHRDLKPGNVLILDGEPVLIDFGIAQAVDATRLTQTGMFIGTPGYLAPEIIEGQEAGPEVDIHAWAGTLLYAGTGQPPFGKGTLEMIFYNITAGKADISAAPAELQPLLKAAFQRNPAKRPKAAELAEQLARMLPKSAQPSSPDEISTVPRPDAVAPPPKVTERPSYEISTPPVTPKRLLEGHDQPVPPQQPQDQKYVSLLPNQPDPWPTRRVSPEELRQIQREAGVYPPQPPPAASAGPAAPAAPSVPVAPATGNGPAVPPGETDVPTRRVRPDSAAGLRMNSGPQSGPQSGPQAPDYGRPNPIPVQPPPYIPPQFPPPQPDRLTKREPYVPGAQPGKPLQRSRAYGVASAMLLVLLIVAAVLAPVLVSVVALPIAILLRAADLAQPQLAARRAAGAAALDVVRVFAYPAALAKSAGITLALVLYALILGLPVTLLLTVVAGMNSANALAWGAAIALWTVCAGPGVEGPGKQMRRTLASLVPSRTAAMVMAGVLAAGAALSLILAYGTFGDNPRGGVWTPLNVEPVTEQLDQLGGNSGG
>NZ_CP017717.1|WP_080045458.1|11785531_11786044_+|hypothetical-protein
MTLQWVPAAERTDLLADPVARAVRDVEGAEVAEIDPDLADTAAFCEKYGVTLDESANCVVVAAKRGGETRYAACMVLATMRVDVNGVVRRHLDARKASFAPMAEAVELTGMEYGGITPLGLPEEWPILVDTHVAEHARVVIGSGVRRSKLAVSGAALAGLKRAEVLSLAG
>NZ_CP017717.1|WP_080045457.1|11783910_11785470_+|flavin-monoamine-oxidase-family-protein
MGDGKGAALTRRGLLVGIGAAGGAGAMYAAMGALGLAPTGQDKKYTPPRQGDFTLSGRASAKVVILGAGVAGLTAAYELGKAGYDCTLLEARQKAGGRNLTLRGGDRLTELNGPAQDVRFGAGVYFNAGPGRIAQWMVTLDYCRELGIPIETFINNNASAYVHTNGQTVRARTARADMYGYVAELLAKATNVGALDKTLTKDDRERLLEFLRRFGDLGPKLDYEGTERRGFTKFPALDGGTPMPAPGTLHQVLAAGTGRAITNDFGYEQATPMFQPVGGMDAIVTKLQQAVGQERIRTNAKVTKITTLDDGVEVAYTGGTIKADYCIATLPPHLLAKIPHNLGARVTAALATPVPIAAGKIGLEYGRRWWEMEDRIYGGVTETDLDITHIWYPSHDYHAERGLLVGYYNTERVAELYGALTPEDRRRRALTQGKKIHGEKYRQNLLSSVSIAWERQEHIQGGWMRWPSFDSSFTLLQRPAGRVYFAGDWLTHLIAWQAGAMESARGAVTQLHRRVLQSP
>NZ_CP017717.1|WP_080047530.1|11783075_11783918_+|M55-family-metallopeptidase
MKVYLSVDMEGVTGLTDPEEMHAGKRGYERGCELMTADANAAIEGAFAGGASGVLVNDAHGSTKNLRIDLLDPRASLIRGPGKAQRMAHGLDGSFQAAGFVGYHARAGVPHGVLNHTWMGKEIQNVYLNGELCGETRLVAACAGFHGVPVVLVTGDEAVGEEARELLGDVETVAVKKGIDKFSAELLPPVVAQSRTREAMARALGRLNDFTPYVVEAPYTLGVEWNSTAIAAAVSLIPGVKAAGARHTEFSTDDFTQIMALFGLFASIAGQVACGSGPYG
>NZ_CP017717.1|WP_080045456.1|11781867_11783079_+|hypothetical-protein
MRVTWSAGGHLTFRLDAEDEITGRASDEYPIKLAINSCSIGGVPDDAHPDLFAVAAWTIVAPWTRRRITFDRAVSAELAQALHDGWGVEAGPVGAEPRRPGTRLAISYSGGADSVAAATIFSEAPFVHFRRVAHPRVPNRWPHYRSDVLAKLAAKTGRELSVVTSDLEYTLAEPRPGYPEHHAVAAGALLLADRLDLGGLGFGYEMGSRWLGGGRYLWRFTPDNPMWAPHGRWGRLFAAAGVHIVLPVGGVSEAVTMRLALSSPLKEQVRWCLRGTDGPCRNCGKCLYKELIQAAVERRPLDTPITADRSVARKYLQKPPYGGQEMIQYGLARVPGIENTLFAPALDYFDVSEESTSWLDHCYPPALEEIPERWRAEAAAFVEANVGLMTESEVRKVESWGSA
>NZ_CP017717.1|WP_080045455.1|11781505_11781877_+|hypothetical-protein
MMRVPVPARLRRAVRTWFDSRYISIADHRQDIRDALWEVQTLRREMATLQSEVERLRNARPAAAAPKPDPALKAKADDAHRLAQETAKALDGVLQNEVLVWQAIDELRAKLDEPGRSEEQPCA
>NZ_CP017717.1|WP_080045464.1|11793622_11793982_-|hypothetical-protein
MRFTRIVRTEDGGSAFEDGELALEQRQVAEGVPPMAVGALPSRDGVQFLRSAAFDSSAHPAPREQWVVMVKGMIEVVVSDGSRRRFGPGDLVLAADTSGKGHVTTGVGEPPFEALFIPV
>NZ_CP017717.1|WP_080045465.1|11793981_11794416_-|hypothetical-protein
MSNTFDVKQWADRYVAQWNEPDPATRGALVRDLWASDAVHVLIDPPEAIRDAAAAIAFPAPPLEVRGHDALEARVRRAYEMFVAPGEHVFEAAGEAVLLLPRVVGVRWSMVSTRTGEAVGGGLDVLALDEDDRIRTDHQFIGGS
>NZ_CP017717.1|WP_080047531.1|11794767_11795550_+|helix-turn-helix-transcriptional-regulator
MTVATKPDRFGRELRRWRTRRRFSQLDLAIRADTTQRHLSFLEQGRSRPGRAMVVRLAESLGLSLRERNALLLAAGFAPVYAESSLDAPELSPVREALERVLDGHLPYPAVVVRPYGELVAANAAFGVLCEGVAPALLKPPINVLRLALHPDGMARRVQNLAEWGRHITGSLREQASRSPDPELDGFVAELDGYLPDLDPPAEHLGFAVPLRLRVPEGELRLITTLTSFATAVDVTLSELRLEAFLPADEATAEILRQRA
>NZ_CP017717.1|WP_155129163.1|11795776_11796172_+|hypothetical-protein
MDKSSPVGRTTGLVVAGALAGAALVGAGVALADGLPGSSPKVTYVKENRTIPPGYLSTNVVCPEGQQAIGGGFAHVGEHQQEHPVIAEISAPSNTSGEPDDPTNAWTFFFVNDKKRTTPVEVHVICTPIDD
>NZ_CP017717.1|WP_080045467.1|11796168_11797011_-|helix-turn-helix-domain-containing-protein
MDRSRELADFLRSRRARITPDRTGLPADGRARRVPGLRRDEVARLAGVSTEYYTRLEQGRAGNPSPEVTEALARALQLDPAEREHLTDLLTRPSRRAPITPQRVRPGLHLMLQTLDHVPAFILGRRTDVLASNRLAREVLTDFEALPVPQRNLARYYLLDPEARTRTGEWERIASETVAMLRLEAGRYPDDRRLADLVGELTLRSPEFSTWWNDHRVLRRTHGSKHYHHPLVGELHFSYESLQPPGDPDQTLCVYNVEPGSPTADALRLLTSWTAPAASS
>NZ_CP017717.1|WP_080045468.1|11797282_11798044_+|SDR-family-oxidoreductase
MITSLSGRVAVVTGASSGIGEATAEHLAELGARVAVLARRAERLDGLVSRIEKAGGRALALAADVTDAAAMRAAAARVASELGGADLLFNNAGVMLPAPIEELAADQWQRQIDLNVTGLMNVIGAFVPQLVQAAGERGVADLINTSSIAAQNIFPNFAVYSGTKAFVTHLSRHLRAELGPKNVRVSAIEPGIVGTELQSHVTDEGALAWLEGSKQEMEWLTPQDVARTVGFVASLPPRANLQQVTIMPTGQAS
>NZ_CP017717.1|WP_080045469.1|11798159_11798777_+|deaminase
MKITLATFLSLDGVMQAPGTPTEDTSGGFEHGGWQFPYADEELETYTDRWFAEADAFLLGRRTYEIFAAYWPTVTDPDNVVASSLNTLPKYVVSTTLGRAEWHNTTIIGSDVLKEVAELRARPGRELQIHGSGTLARTLLDHGMIDELRLWTYPVVLGSGMRLFEPGRTPTAMRLVETRPTGSGCVLSVYRPAGRPTYGDFSKEG
>NZ_CP017717.1|WP_080045470.1|11798827_11800291_-|HAMP-domain-containing-histidine-kinase
MRLSLRARLLSITVALLVVGLVVISSVVVRQLEHQLMTRVDAQLAPMGRALTAVPPELLAVMQAHAGGQAPVDPLDLITAGYAAYLSADGTVLRSFGDGAGPSLPRLDTAAVTAHAGRPFTVEGADGQEWRAVALPSNGAGGVGGPGGAGGRSAVVAAVSLEALHATVGRVRLACLVAGSILLAVLALAGGIAIRAGLAPLRRVEETAAAIADGDLSRRVPEPATPGTEVGRLARSLNKMLAQIEQGVAAKVESEARMRRFVADVSHELRTPLFGIKGFSELYRMGGTEAAPAMARIESESGRLAKLVDDLLLLAGLDESDGPALDLTPMDLRTLAADARHDFAALDPARPIAFTGPSGGPAASAPVLGDEARLRQVVSNLVGNAVTHTPAGTPVRVGVGTDGGEAVLVIADEGPGLAPEEASRVFDRFYRADGSRARATGGAGLGLAIVRSIVAAHGGRVELRSAPGRGAAFEIRLPAHPPLEQPR
>NZ_CP017717.1|WP_155130135.1|11800287_11800989_-|response-regulator-transcription-factor
MGERLLVVDDEPTVKELLSATLRFAGFTVSSADSGAQALESARRDPPDLVLLDVMLPDLDGFEVLRRLRGLPRAGGRPGPVPVLFLTARDATADKINGLRLGGDDYVTKPFDLEELLARIQAILRRTGAVPDDRTLVVGDLEVDPDAHQVLRAGRPVRLSPTEFRLLHHLVLNAGRVVPKAQILEHVWRYDFAGDTSIVDTYVSYLRRKLDTTGPKLIHTVHGVGYLLRRPRP
>NZ_CP017717.1|WP_155129166.1|11801018_11801783_-|hypothetical-protein
MIEMGVLRAEWTKFSSIRATMVLSLVTVAVSGLFGWMFGNVSATEYAATSAQERLGFQPLDMGMRGVFIAQLLIAALGVLVASSEYGSGTIRASLAAVGGRGRLLAAKAGMTVLTALPVSVAAIWVMYAVSQVTLAAGGAPYLMPGDPAASRMLLLGPVVLTMLALFGLALGFLLRTTAAAVNAGTAFLLLPVLASASPAPVRDFIQNFWPNTTAFQALSGTSALPPVVAYGLFVGFVAVMMIGAFVRFDRQDT

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Crispr_ID: NZ_CP017717_39

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_39

12102406-12102513

Orphan

Consensus_repeat	Method
CGCGACAAGATCTGCGGTCGGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_39

>merge|NZ_CP017717|39|12102406-12102513|CRISPRCasFinder
CGCGACAAGATCTGCGGTCGGGCGAGGATCCCGACACGGTCACGCATCAAGTTCCGCCTTCACGGGACGGATCCCGCACGATCGCGCGACAAGATCCGCGGTCGGGCG

>NZ_CP017717|39|34|12102406-12102513|CRISPRCasFinder
CGCGACAAGATCTGCGGTCGGGCG	AGGATCCCGACACGGTCACGCATCAAGTTCCGCCTTCACGGGACGGATCCCGCACGATCG
CGCGACAAGATCCGCGGTCGGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080045687.1\|12105597_12106728_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|366659
NZ_CP017717.1\|WP_080045677.1\|12094031_12094979_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176198
NZ_CP017717.1\|WP_155129227.1\|12101034_12101634_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP017717.1\|WP_155129224.1\|12097468_12098113_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045682.1\|12098293_12099142_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NZ_CP017717.1\|WP_080045688.1\|12106724_12107435_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP017717.1\|WP_080045692.1\|12110851_12111430_-\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NZ_CP017717.1\|WP_080045680.1\|12096983_12097403_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NZ_CP017717.1\|WP_080045678.1\|12095613_12095988_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047558.1\|12099333_12099756_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319945
NZ_CP017717.1\|WP_155130147.1\|12102853_12104065_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP017717.1\|WP_080045689.1\|12109369_12109828_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045685.1\|12104082_12104739_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP017717.1\|WP_080047557.1\|12093160_12093769_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
NZ_CP017717.1\|WP_080045691.1\|12110342_12110855_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319968
NZ_CP017717.1\|WP_080045679.1\|12096026_12096860_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_155129221.1\|12095242_12095461_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080045690.1\|12109939_12110296_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP017717.1\|WP_080045686.1\|12105070_12105598_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080047560.1\|12107473_12108649_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080045688.1\|12106724_12107435_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.06426e-103
NZ_CP017717.1\|WP_080045677.1\|12094031_12094979_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.12292e-63
NZ_CP017717.1\|WP_155129227.1\|12101034_12101634_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.08912e-24
NZ_CP017717.1\|WP_080045692.1\|12110851_12111430_-\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	7.03559e-24
NZ_CP017717.1\|WP_080045682.1\|12098293_12099142_+\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.03149e-82
NZ_CP017717.1\|WP_080045680.1\|12096983_12097403_+\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	8.29921e-20
NZ_CP017717.1\|WP_080045687.1\|12105597_12106728_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	2.76435e-09
NZ_CP017717.1\|WP_080047558.1\|12099333_12099756_-\|VOC-family-protein	gnl\|CDD\|319945	cd08357, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) familyprotein, glyoxalase I, and type I ring-cleaving dioxygenases. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.28344e-69
NZ_CP017717.1\|WP_080045685.1\|12104082_12104739_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.96473e-67
NZ_CP017717.1\|WP_155130147.1\|12102853_12104065_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.81971e-43
NZ_CP017717.1\|WP_080047557.1\|12093160_12093769_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	3.18104e-13
NZ_CP017717.1\|WP_080045691.1\|12110342_12110855_-\|glyoxalase	gnl\|CDD\|319968	cd16361, VOC_ShValD_like, vicinal oxygen chelate (VOC) family protein similar to Streptomyces hygroscopicus ValD protein. This subfamily of vicinal oxygen chelate (VOC) family protein includes Streptomyces hygroscopicus ValD protein and similar proteins. ValD protein functions in validamycin biosynthetic pathway. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.04696e-46
NZ_CP017717.1\|WP_080045690.1\|12109939_12110296_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.46041e-15
NZ_CP017717.1\|WP_080047560.1\|12107473_12108649_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	3.5718e-30

>NZ_CP017717.1|WP_155129227.1|12101034_12101634_+|MFS-transporter
MSSLCRPGRGRLHGLDDPYEDLGRKGARVIFRPLAIRDFRRYFAGQTASTFGDSLTPLALAFAVLHLTGSPVDLGIVVLSTRLPVIVLTLVGGAAGDRYSRRTIMLLADLVRFAAHGVTAVLLITGTAQIWMLVVLQLAAGAGSAFFNPAAVGLIGSLARGSTSRRPTRSSRSPAAPPPSWRSGQRERWWRWSGRAGRC
>NZ_CP017717.1|WP_080047558.1|12099333_12099756_-|VOC-family-protein
MLMELPRFHLAVPVDDLDAARHFYGDLIGCAQGRSSDRWIDWNLHGHQFVTHLAPVRAERVHNPVDGHDVPVPHFGLILTIPEFHELADRFREAGTAFVIEPYLRFEGQPGEQWTMFLLDPAGNALEFKAFADDSQVFAV
>NZ_CP017717.1|WP_080045682.1|12098293_12099142_+|SDR-family-oxidoreductase
MSFIVTTGATGRLGGRVAARLAAAGVEQRLVSRHATARAPRLDRATAVDAAYGDRAALRQALDGASTVLFVSASESADRLDQHRAFVDAARDARVSHLVYVSFYGAAPEATFTLARDHWATEQHIRDSGLTFTFLRDNLYADFLPGMTGDDGVIRGPAGQGRVAAVAQDDIAEAAANVLLAPKEHEGATYDLTGPQALTLDEVAATISAATGRTVTYHAETVPEAYASRESYGAPAWQVEAWVSTYLAIAAGELEGVTDGIPALTGHPATSLAELLGRSPTS
>NZ_CP017717.1|WP_155129224.1|12097468_12098113_+|hypothetical-protein
MSMFRSAEGLPDHGCGALGRVAHGALTAPIGSRGAPPGGPRLFLGYNTLPDPPFPLAGFIEYEMDPRVAECELGSVLRTLVESFRTQPVPPEGTFDDTHRRSAAAMRVDAMVVVFSGRAFSPDQSPPARALWDNLVEGYYHEGDAEACAGARAALVGLGLDRADGRVILLAERDSAGEHGQPERVGVYPEGTLYDLLGDLLDAQYRWTRAAFGL
>NZ_CP017717.1|WP_080045680.1|12096983_12097403_+|RidA-family-protein
MTSGVRLIRNDRLTQQVDYAYAATVDAPVRSIWVAGACPLDLDGKTVAVGDYAGQAHQVMRNLVTALEGAGASLTDVVKTTVYVASTRQADLVTAWEVYREYMGEHDVPSTLLGVTVLGYHDQLVEVEAVAVIAGEGQA
>NZ_CP017717.1|WP_080045679.1|12096026_12096860_-|hypothetical-protein
MRVHLAVLAAVTILPCAALPALTVLPASAAATVSYECTTKATGEKQEVGLDVELTVPAQATVGQQMTIGWSGVFVTGKELTAPATGMEGELNMYVYAGISGIDDLTSATGVAELGTVIPGEPVAIPSTATMTTTPRKSGSGTVHAGAINFGLTPQDRLVECEVKNKDSLTQYPFTVLGADGSTPTTTDTSTTGTSTTGTPTPEASEDDTGSEEQESPATTDSADIPAGGVDTGAGGLAGPDGRALVLTGLVITLAAATGLRLRRPRPRTHQGPDTGP
>NZ_CP017717.1|WP_080045678.1|12095613_12095988_+|hypothetical-protein
MATVTFRDESATGRPLDEFTLPGLPARISARELVRLRVREEVARHNAEPGSRFRGLVRPGAAETELNGRRIDWERQADLAERAFQRNGFLLLVGERQIEDLAETVDLAADPVVSFVKLVPLVGG
>NZ_CP017717.1|WP_155129221.1|12095242_12095461_-|hypothetical-protein
MKSQDECADGADGRRPPTAFRPADAGMLVLHQLAVPAQDGVWADDKPESTQDGTGQGGQERRQEEAEGFARP
>NZ_CP017717.1|WP_080045677.1|12094031_12094979_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MRAVRNTDQGILVTEIDEPVAPGVRLTIASTGICGTDVTFAAGGVQGYTVQGYTYGHEFAGTAADGRSYAVEPLVHCGQCDQCRTGHVQRCTAPEHGTLGIFRDGGMCDAVTVSENMLVPLPAGLDVRDACLVEPASVAWHGVRRAALTPGERVAVVGGGSIGLLAVAAARQRGHDVDIEVRHKHQRMAAERLEAGPAEGLYDVVIDAAGSESGLARCAELARPGGRVVLLGVYVHTVPIPGVARLVKELTYVNSISYSRHDGIRDTEQAAALLAGNPAIAQTVITHRFPLDDAAEAFRVAGDRASGAIKVVLHP
>NZ_CP017717.1|WP_080047557.1|12093160_12093769_-|TetR/AcrR-family-transcriptional-regulator
MALLDTRGVDALTMRNIAEGLGCTQASLYRHVRNREELVTLLVDRALSVASSVPPGDTDWAEKAAWSARLFREHLLRHPGVASLLRGTERLGPNSLAGVQYSLDLFIGAGFSPRLAYAAAASLATFIIGSVNFNLGLDSSDPEESRHRRLLYRSRDAATLPLIVQHADALAEVSSDDEFEVGLKALLTGFRALIQNPDITHD
>NZ_CP017717.1|WP_155130147.1|12102853_12104065_-|HAMP-domain-containing-histidine-kinase
MRSRVRPTLRLRLTLVYGAVFLLAGLVLLGVTYLLFQQQLVQTFDDRYASPAEPGRFKQLLIKQDGVTLYGDAAMEWLWRQQQELRDAAVTSLLTQGAIALVAVGGAAVGLGWWVAGRVLAPLHLVTATARKIAAAPMAERGLHERIALRGPADEVKDLADTFDTMVERLDHSFDGQRRFVANASHELRTPLTLNRALVELAMHRRTASSDVKELGESLLEINARHERLISGLLLLARSEQEVADRSPVDLADIVTHVTAQTADQAADAKITVYEVVAPAPTTGDALLLERLVHNLVENGIRYNLDDGTGWVRVVSRTVSGDKVEVEVSNTGPAVPPYDVPLLFKPFHRQAGERAVTGTSAGLGLSIVRSVAIAHGGDVRARPRDGGGLIVAVSLPRATDRSW
>NZ_CP017717.1|WP_080045685.1|12104082_12104739_-|response-regulator-transcription-factor
MRVLVVEDEPMLADAIAEWLREETHAVDLAHDGEAALERIAVNDYDVVVLDRDLPRVHGDEVCREMVASECDARVLMLTAAAQLDDRVTGLSMGADDYLTKPFAFPELAARVLALGRRSRPAAPPVLRRAGITLDPARREVFRNGRFVPLSKKEFAVLAELLRADGNVVSAEQLLEKAWDENADPFTGAVRLTILKLRRKLADPPVVETVAGVGYRIA
>NZ_CP017717.1|WP_080045686.1|12105070_12105598_+|hypothetical-protein
MRRHVLSALVTAPFALTLLLTGCGSGDTGGSDVASVSGTGNQAAASAKPSEDPQAKGLKYAQCMRENGIDMPDPEPDGRVMMKFDKNTPQEKVQAAQEACKQYAPSGTRQGGGDPKQAENMRKLAQCMRDNGVEAYPDPEGGMMRITPEVGEDPDFKSAQEKCQKESADAGLGGS
>NZ_CP017717.1|WP_080045687.1|12105597_12106728_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MGMATIDGKAEPEATPPRQRRRRGKGRLVAALLVVAAAAGGGFVAVNSADLLKGGAGPTASAGALPPATTTVTRQTLNDTRDADGELGYGPVTSAVARQPGTITWLPDSGATITRGKSLYRLDNDPVTLMYGGTPAYRDLKIGVEGKDVESLERNLSKLGYDGFTVDDEFTYDTYEAVLEWQEDRGLPETGVVKLGQVVFAPGRVRVESLETEEGSPAQPGQKVLTYTGTDKVITVELEAEDQRMARKGAKVEVTLPDGKSVKGKVTEVATVIVPGEGQEDPDTRVEALVSIGNAKSARGLDKASVDVTFTASQRKNVLTVPVAALVALQEGGFGLEVIEGGRSRYIAVETGLFAGGRVEVKGDGLSEGMTVGMPK
>NZ_CP017717.1|WP_080045688.1|12106724_12107435_+|ABC-transporter-ATP-binding-protein
MTYPMISLHEVSRTYPGGVAALKEVSLRIDHGELVAIVGPSGSGKSTMLNVVGTLDRPSSGTIEIDGYDVSKLSDNQLSALRATTIGFVFQSFHLAAKVPALDNVADGLVYTGLSRAERRRRAAAALKRVGLEHRMDHEPHELSGGERQRVAIARAVAGEPPLLLADEPTGALDSVSGTGVMELLHELNAGGTTIVIITHDREIAASLPRQVRMRDGQIISDSAFTPSEPVESGVA
>NZ_CP017717.1|WP_080047560.1|12107473_12108649_+|ABC-transporter-permease
MRAADVMRVGAVGLRTRPLRAFLSALGIAIGIAAMVGVVGLSSSSGAELDRQLSALGTNLLTLSAGSTITGEAAQLPKDAEAMIERIGPVQAVSSIGKAADAKVYRSEQIPEAQTGGISTYAARLDLPATVGATLRSGTWLNAATERYPAAVIGSLTAQRLGIGAAGPDTQIIVGGIRFTVVGVLEPVALATELDSGVLVGWPVAESRLGFDGHPTTLYTRSEEAKLESVRQVLAGTANPEAPNEVDISRPSDALAAKQATSQAFANLLLGVGAVALLVGGVGVANTMVISVLERRAEIGLRRSLGATRGQIRTQFLAESLLLSALGGTGGVLLGTGVTMGYALYSGWPSVVPAWATAGGLAATLLIGAIAGLYPAIRASRLSPTEALSTP
>NZ_CP017717.1|WP_080045689.1|12109369_12109828_-|hypothetical-protein
MRARRHALPAVLLSVAAMTGVTVTTACTSTTEPPTLEEATRQLDADAGELLKATELHLSAVARTDDDTCVPGQLRHFFQAESDLAEASDGLLARLRALGYDKVVDDHDLRDEEQDVAVLRNPRNRLEFELTVLSGEDARVRVVGKTTCYATE
>NZ_CP017717.1|WP_080045690.1|12109939_12110296_+|STAS-domain-containing-protein
MYDRRPPRSRMTFETDDRARVTLVSHPFGLRITGEIDRGNRHLLAGALTWALLAGSHDIRLDLSGLTFIDVAGMRLIVTAAARLSSDREVILDPISPAVRRVLSLTGWDQAPGLRVCS
>NZ_CP017717.1|WP_080045691.1|12110342_12110855_-|glyoxalase
MTVRGIDHVGVTVPDLDAATEFFARAFGAEVLYDTLPRAQGPKGGWATERRLGVPQGTAEVAVRMLRLPNGPGIELFEFSGPRQGGAALPCDLGWQHVALYVDDLDEALRRFTEAGGLRLSDPVPLPGPESGEHNRFAYCRTPWGGTVELLTYPDAQPYEKETDQRRWRP
>NZ_CP017717.1|WP_080045692.1|12110851_12111430_-|DUF421-domain-containing-protein
MIDDLFHTGVSLADKAIRTVAVYVTVAALLRLGGKRGIAQLNNFDFVVMLLMSNVVQNAIIGPDNSLAGGLAGLVILMAVNAVVVRLAATVPAIGRLVEGSPTVLARDGGYVRSALRRLGVRQADLDVAIQLRGGTSVADTSLVRLEPGGAVLVRLRPDEENAERGDVAELRTRLDRIERKLDALAGTGGST

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Crispr_ID: NZ_CP017717_40

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_40

12542691-12542812

Orphan

Consensus_repeat	Method
CGTCTCGCGCGACTCACCTCTCGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP017717_40

>merge|NZ_CP017717|40|12542691-12542812|CRISPRCasFinder
CGTCTCGCCCGACTCACCGTCACACCCGCTGACCGCCTCGCTTGCAGCACCGTCTCGCGCGACTCACCTCTCGCGCGACTCACGTCTCGCGCGACTCACGTCTCGCGCGACTCACGTCTCGC

>NZ_CP017717|40|35|12542691-12542812|CRISPRCasFinder
CGTCTCGCCCGACTCACCGTCACA	CCCGCTGACCGCCTCGCTTGCAGCAC
CGTCTCGCGCGACTCACCTCTCGC	GCGACTCACGTCTCGCGCGACTCA
CGTCTCGCGCGACTCACGTCTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046013.1\|12541306_12542689_+\|aminopeptidase	unknown	unknown	gnl\|CDD\|283275
NZ_CP017717.1\|WP_080046005.1\|12531471_12531666_-\|ferredoxin	unknown	unknown	gnl\|CDD\|379198
NZ_CP017717.1\|WP_080046021.1\|12556012_12557215_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046016.1\|12545867_12546806_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP017717.1\|WP_080046006.1\|12531693_12532905_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP017717.1\|WP_080046008.1\|12534617_12535256_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379534
NZ_CP017717.1\|WP_155130168.1\|12554687_12555992_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP017717.1\|WP_080046012.1\|12540341_12540920_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP017717.1\|WP_080046017.1\|12546818_12548045_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP017717.1\|WP_155129330.1\|12536912_12539207_+\|DUF2264-domain-containing-protein	unknown	unknown	gnl\|CDD\|378358
NZ_CP017717.1\|WP_080046014.1\|12544230_12545010_-\|trehalose-utilization-protein-ThuA	unknown	unknown	gnl\|CDD\|153236
NZ_CP017717.1\|WP_080046019.1\|12549444_12553383_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277344
NZ_CP017717.1\|WP_080046020.1\|12553438_12554545_+\|HupE/UreJ-family-protein	unknown	unknown	gnl\|CDD\|379373
NZ_CP017717.1\|WP_080046010.1\|12535657_12536737_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP017717.1\|WP_080046018.1\|12548303_12549311_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP017717.1\|WP_080046007.1\|12533194_12534481_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP017717.1\|WP_080046015.1\|12545019_12545871_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP017717.1\|WP_080046009.1\|12535273_12535588_-\|ligand-binding-protein-SH3	unknown	unknown	gnl\|CDD\|171110
NZ_CP017717.1\|WP_155129333.1\|12543091_12544351_-\|gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP017717.1\|WP_080046011.1\|12539869_12540250_-\|DUF4267-domain-containing-protein	unknown	unknown	gnl\|CDD\|372907

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080046013.1\|12541306_12542689_+\|aminopeptidase	gnl\|CDD\|283275	pfam05576, Peptidase_S37, PS-10 peptidase S37. These serine proteases have been found in Streptomyces species.	4.08032e-150
NZ_CP017717.1\|WP_080046005.1\|12531471_12531666_-\|ferredoxin	gnl\|CDD\|379198	pfam13459, Fer4_15, 4Fe-4S single cluster domain.	1.38883e-08
NZ_CP017717.1\|WP_080046016.1\|12545867_12546806_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.84217e-84
NZ_CP017717.1\|WP_080046006.1\|12531693_12532905_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	7.04179e-86
NZ_CP017717.1\|WP_080046008.1\|12534617_12535256_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379534	pfam14278, TetR_C_8, Transcriptional regulator C-terminal region. This domain is a tetracycline repressor, domain 2, or C-terminus.	1.27591e-10
NZ_CP017717.1\|WP_155130168.1\|12554687_12555992_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.10919e-50
NZ_CP017717.1\|WP_080046012.1\|12540341_12540920_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.81231e-08
NZ_CP017717.1\|WP_080046017.1\|12546818_12548045_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.16476e-66
NZ_CP017717.1\|WP_155129330.1\|12536912_12539207_+\|DUF2264-domain-containing-protein	gnl\|CDD\|378358	pfam10022, DUF2264, Uncharacterized protein conserved in bacteria (DUF2264). Members of this family of hypothetical bacterial proteins have no known function.	2.46012e-153
NZ_CP017717.1\|WP_080046014.1\|12544230_12545010_-\|trehalose-utilization-protein-ThuA	gnl\|CDD\|153236	cd03142, GATase1_ThuA, Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA). Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA). This group includes proteins similar to SmThuA which plays a role in a major pathway for trehalose catabolism. SmThuA is induced by trehalose but not by related structurally similar disaccharides like sucrose or maltose. Proteins in this group lack the catalytic triad of typical GATase1 domains: a His replaces the reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. S. meliloti Rm1021 thuA mutants are impaired in competitive colonization of Medicago sativa roots but are more competitive than the wild-type Rml021 in infecting alfalfa roots and forming nitrogen-fixing nodules.	9.39199e-133
NZ_CP017717.1\|WP_080046019.1\|12549444_12553383_+\|hypothetical-protein	gnl\|CDD\|277344	cd07399, MPP_YvnB, Bacillus subtilis YvnB and related proteins, metallophosphatase domain. YvnB (BSU35040) is an uncharacterized Bacillus subtilis protein with a metallophosphatase domain. This family includes bacterial and eukaryotic proteins similar to YvnB. YvnB belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.02441e-27
NZ_CP017717.1\|WP_080046020.1\|12553438_12554545_+\|HupE/UreJ-family-protein	gnl\|CDD\|379373	pfam13795, HupE_UreJ_2, HupE / UreJ protein. These proteins contain many conserved histidines that may be involved in nickel binding.	8.98104e-49
NZ_CP017717.1\|WP_080046010.1\|12535657_12536737_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.058e-98
NZ_CP017717.1\|WP_080046018.1\|12548303_12549311_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.98365e-73
NZ_CP017717.1\|WP_080046007.1\|12533194_12534481_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.57621e-44
NZ_CP017717.1\|WP_080046015.1\|12545019_12545871_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.45106e-70
NZ_CP017717.1\|WP_080046009.1\|12535273_12535588_-\|ligand-binding-protein-SH3	gnl\|CDD\|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	7.84598e-27
NZ_CP017717.1\|WP_155129333.1\|12543091_12544351_-\|gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	4.72015e-44
NZ_CP017717.1\|WP_080046011.1\|12539869_12540250_-\|DUF4267-domain-containing-protein	gnl\|CDD\|372907	pfam14087, DUF4267, Domain of unknown function (DUF4267). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.	2.91286e-17

>NZ_CP017717.1|WP_080046013.1|12541306_12542689_+|aminopeptidase
MRLRFLAALAAATLALLLPALPVTAAAQDELLERLKAIPGLTVVSETQPAGYRFFVLSYTQPADHRHPGRGVFQQRLTLLHRSEQAPVVLATSGYGLPVNPAASRAEPTRLLDGNQVSVEHRFFRSSRPSPADWDDLTIWQEATDEHRIVQALKTIYSGKWIQTGVSKGGMTSVYHRRFYPDDVDGVVAYVAPDDPVNPQDLAYDRFFDRVGTPACRAALENVQREALKRRERMVALLEADAARNGYTFGRTLGSADRSFEMTVLDTAWAFWQYLGVADCPSVPAVTATDEELYAWIDNVASFAFYTDQGMEYYTPYYYQAATQLGWPDLAFRHLRGLTRYRGLYQPNSVLPAELRSRHDPWPMLDVDHWVRTRSERMMFIYGENDPWSAERFTPSRRDSYLYVAPGANHGASIALLPEAERAEATATLLRWADVSMGQQRLPEAAPLPDDPMLPDRHTR
>NZ_CP017717.1|WP_080046012.1|12540341_12540920_+|TetR/AcrR-family-transcriptional-regulator
MTMQTRRERVRAEREKLIVSAARELAEAEGWEAVTTRRLAERVEYSQPVLYSHFKGKGAIMTAVAVEGFASMAEELRAARTEAVDAAGALEAVARAYTAFAGWRPALYDAMFHHQVDLPFGDPDAPPALWAAFNELAAAVRPYAESEDELGALAETFWAALHGLTTLMRQGRLPNDGHERRLALLLSRFIGV
>NZ_CP017717.1|WP_080046011.1|12539869_12540250_-|DUF4267-domain-containing-protein
MLTYLAYGLAIALNLMILFIGARFLLTPHPAAAGYGVPAKENGDAAYLTIKGLRDFTFGVIGLSLLAFAGPTAEAWFMLATALAPLGDTLIVLRHGGTKAAAFGIHFATAVAVLISAALLFTIGLT
>NZ_CP017717.1|WP_155129330.1|12536912_12539207_+|DUF2264-domain-containing-protein
MPIPGEHPRLRWEAAADHLLASVLPYATDGHAQYRLPGRTSRSGTVSDGLEGYARTFLLAAFRIAGAGGDVPPALLERYAEGLVSGTDPAHPYAWPALSDMAQQLVEAASIALALHETRPWLYDRLSPRQQERVVDWLAGFIGKRTPDNNWVLFRVIVEQFLAGVGGPHEPSEITGGLERIEEWYAGDGWYTDGKGRNYDYYCGWALHLYPSLWARMSGDTARQDLYAGRLRRFLEQYQHFFAADGAPVHQGRSLTYRFATVAPLWLGALTGASPLPPGRTRRIADRVLRHFADHGAPDERGLLTLGWYHEFLPVTQSYSGPASPYWASKAFLGLLLPPDHPAWTAPEEPAPVELADQTLTIPAPGWLLHTTSADGIVRLVNHGTDRDRVQPPDGIPDPHYVKLAYTSHTGPEVGEQAAGVDNHVTVLAPDGTPSSRRLIEPLTTADRFAASAYQDGAVRIVTASVVDGASEIRIHRVTAPTGHQVRDGGHPVAAGSETGLFVWQEGDLALARRRPEDDPSLAGLGREGGPAPADERPEGEMALTGRRPEDDLAPAGLGRESDATPAGLGQEGDPKLVDHRPESDPASTDRRPEDHLTAADRRREGHLALADRRPGDDLMPADRRPGGDLMPTDRRSGGDAELSRLRQEDSLARAGRSVGGLTSAVRALHGFTSTGLVTATDTNAFGRHSATPYALATSHPGGTALYASLVWLAGTGQEPPAPEARVEPGDVVVITLPGGGTVTVDMGTDVPTARWEDPAAHHP
>NZ_CP017717.1|WP_080046010.1|12535657_12536737_-|LacI-family-transcriptional-regulator
MVRRAASEGEERRPTTIRDVAAHAGVSVATVSRILSGSYPSAPATRSKVMKAVRELDYVANANARNLAGASSRSVAIIVNSVVSPHYAHVAQGVQTQAALEGKLCIVGTTGGDPERELATVQLMRQEHAECVILVGNVVNNDAYRERMADYARALAAAGSQLVLCGRPTLGPDVPALVVEYDNTGGAYAITSHLLSAGHRRILFLGRREGYTTSDSRITGYRNALADHRVPQDPGLEVDGTMERSEGYRMIRERLAAGPPDFTAVFAGNDLIAAGARQALREHGLRVPDDISMVGFDDLPPSADIDLTTVHVPHEELGRTAVRLALERRQDRSRPAQHVLLGTHIIVRDSVRPLRADVS
>NZ_CP017717.1|WP_080046009.1|12535273_12535588_-|ligand-binding-protein-SH3
MAWIVLVVSGVLESVWAAALSASHGLSRLRPSLLFGAALAASMLGLGYALRTIPVGTGYAVWVGIGAVGTALYGMVFLQEPATAARLVCLALIIGGVVGLKFVH
>NZ_CP017717.1|WP_080046008.1|12534617_12535256_+|TetR/AcrR-family-transcriptional-regulator
MATTRASTTTSAGDRRVRRTQAALARALLDLVEEQDLSRVTVADVAEHAGVSRSTFYDHYRDVHELAEAACTAMIDRLIESLPGDFDSADPEVEATASLESFFASLAEHAGLYRALLGPQGSARVADHIRQRSTAAIRERLEEAVAGADVPEQARPLLSLPLDVPASFTAGALIGVAAEWLQGGCARSPGEMAALTWPLFHSLFRIEARPPS
>NZ_CP017717.1|WP_080046007.1|12533194_12534481_-|FAD-dependent-oxidoreductase
MTPPRSVLIVGASAAGLSTAEALRRQGHQGRLTLLDAEPHLPYDRPPLSKQVLAGDWEPGRAQLRSQAQLDALDAEFVRGEAAVAFDAGAREVRTATGRVLRADAVVIATGLTPHRLPGQQGQAGMREPAGMQGPAGMREPAGMQGPAGMRGPGQQGLAGVHELRGLDDALTLRAHLTAARRLVVVGEGVLGGELAATARKLGLDVTLVGLGQAILADQLGGRVSGLLTRAHAERGVELRLGVAVEELTSAGGRVTGVRLATGEVLPADAVVVAIGSRPATGWLAGSGLSLGDGVECDARCRAAEGVYAVGDVASWQHEGLGRRLRLENRTNATEQAQVVAANILGADRPYTPIPYFWTDQYDIKIQAHGLPSATAEVSIVEGDPEQGRFAAVYREDGRVTGVLGWNMPKQARVLRQQHLATQPVATA
>NZ_CP017717.1|WP_080046006.1|12531693_12532905_-|cytochrome-P450
MSVNEQVLSYPIPAEAPLEPPAEWAELRGGCPVAHVKLPSGDAARLITRYEDVKQVLADPRFTRQLTAPDAARLSADGGGVFNSDVAQIIPDSGDGHLHWRRLVGKWFTAKRMAAMRPRMAEIADSLIDDLVERGAPGDLRAGLGFPLPVYVICDMLGVPAEDRERFSYWSDTLLNLTRYGKEEIEAAQAEFFQYMSDLIAAKRAEPGDDLLSELLAAGGPDEGGLEDLQIIVTGMALLVAGHETTANMIGKMVSMLLADRARWEALLADPSLVRTAVEETLRLDANSGFGLPRYLPVEAEIGGETLPKGTTVICSMAAANRDESAFEDAASMDLTRSPNPHLAFGAGAHSCLGQSLARTELQVVLEVLLRRLPTLELAVPVAELERVEGLAVGGLRTVPVRW
>NZ_CP017717.1|WP_080046005.1|12531471_12531666_-|ferredoxin
MKITVDEDKCCGAGSCVLIAPEVFDQREDDGIVILLDAEPGAGQHAAVREAAAVCPGAAIEVSE
>NZ_CP017717.1|WP_155129333.1|12543091_12544351_-|gfo/Idh/MocA-family-oxidoreductase
MGGRRPRAARAADPAAVRDGGLLQRARLSGRHAQQGERPVSARPLRVVQVGAGAMGLAWLRTLAASSDVELVGVADLDVARAEAAVRSLDSPDGGSGGSGGSLGSGGPRHESVMVAGSLGELLASVEPDAVVNVTVPAAHSPVNIEALFAGVPVLCEKPAAPTLAEALVQAAASEAADRLLMISQSRRYFAALSTFRERIAELGTPGLLTTSFFRAPHFGGFRDEMPQPLLVDMAIHAFDASRYLLRAEPVSVVCESWNPPWSWYQGDASATATFLFSDGTRYVFTGSWCAEGRDTSWNGEWRAVAAGGTATWDGERHVTSSARDQPEDVAPAAHEQIAGALAEFVHALRTGSQPDGTIHGNLRSLAMVEAAVRSAETGERVQIGALLERAYEEALLLPVREEVRERLKAWGAAATVLS
>NZ_CP017717.1|WP_080046014.1|12544230_12545010_-|trehalose-utilization-protein-ThuA
MTIRVLVWGENRHEQAEPEVAKIYPDGMHNAIRRGIEERLGERATVRTATLDDPEHGLTEDVLAATDVLTWWGHAAHGEVADEVVERVHRHVLSGMGLLVLHSGHWSKIFTKLMGTTCTLRWRSQNDRELIWTVNPTHPIARGIPHPIEIPAQEMYGEQFDIPTPDELIFISSFTGGEVFRSGCTFRRGNGKIFYFSPGDQDYPVYHHPDVLQVLANGVEWAAGDPARRELPTLLRYEMGDFFNGHGYRGAMHNKESGQ
>NZ_CP017717.1|WP_080046015.1|12545019_12545871_-|carbohydrate-ABC-transporter-permease
MNLTVRPGAGGARAGLDPRRLPMTALGVLFLAVMLFPVYWMVNSSLQSSSGATTRDWLPLDATLSGYAKAISEQGQNFVTSLLIALGTVVLTLVVATPAAYGLSRFRSRGASTFVLVLLITQMIPAMVIANALYPLFNQLYLINNVFGLILANTAAGIPFAVLLMRAFMGSIPRALVEAAMVDGAGQLRAFLSIVVPISKNAIVTAALFTFLSAWSDFLFALTLTSTPEVRPITLGIYDYISANTQDWDTVMATAVLASIPAALLLIFAQRYIAAGAVAGAVK
>NZ_CP017717.1|WP_080046016.1|12545867_12546806_-|sugar-ABC-transporter-permease
MTSAHLSLTVAAGERRTILWTRLLRRATPWLFSLPAVVFVAMFFGYPIVQNVVMSFQEYTTSTFYSGAAPWVGLANYATILSSYLFTTTLVNTALFTVGSITFQFVIGLALALFFKRAFPLSGFLRSMLLLPWLIPLIASSAVWKWLLDQESGALNQFLGLFGVPAVPWLVDPTLALAGVIGVNIWLGIPFNVAILYSGLQAVPKELYEAGSLDGATGWKAFRHITWPNLRPVVSVVIVLGVVYTLKVVDIILGLTGGGPANSTQTLATNAYNKSFVEFNFGEGAAISNVLIVVSLVFALVYLYLSRREPSE
>NZ_CP017717.1|WP_080046017.1|12546818_12548045_-|sugar-ABC-transporter-substrate-binding-protein
METAQKRQGKAPKVAVAAALLAPLTLTACTGAAASGTESPNTLTIQDYYDETQDPIYHSCARSVGVSLEISHVAGPGLIPKVLQQSSSRTLPDVLMLDNPDVQQIAKSGALSPLSDHGLTGEGMVPAVVQAGTYAGKLYGLAPGVNTLSIFYNKDLFDQAGITTPPATWDELRAVARRLTGQGRYGFAMSTINTYEGTWQFLPFMWGNGGTERDITTPQTVQALRFLVDLQNDGSMSRSSIIWSQDDVIDQFVAGKAAMVVNGPWQLPALKKQREVRWGAFTIPKRDPSQTTVAPLGGEVFTVPRTGNHAKMAKAGQFVKCLVSPEKQLETARIKQNVPSNPDVAEQAGKENPALAPFVTTVRTARSRTALLGPDWPKAATKIYNAVQIALTGKAAPAEALRQAQGEQ
>NZ_CP017717.1|WP_080046018.1|12548303_12549311_+|LacI-family-transcriptional-regulator
MVTMRDVAARANVSIATVSFVLNGTKRVAPETRARIEAAIEELNYRRNVVARALASSRTRILALLHPDLESRPNATVIQFAMGAAHGARERGYDLVLWPVNDDEQMSHLLAGGLVDGALLMEVQIRDSRVERLVASGIPFALIGRTENDDLPYVDIDFATTLREAVAHLRSYGHERIALVTQRTKGGAEPGRIMRVESAYRDAIAPLGTPPVVIPVDGTSAGGREAARVLCEEHPACTAVVLVNEGASAGLAKGLRAAGRAIPGDVSVISASTTRELGEMIEPELTVMAAPAAELARLAVDALIDQIEGVPDAPPHTLIPCTLVPGESVGPVPVL
>NZ_CP017717.1|WP_080046019.1|12549444_12553383_+|hypothetical-protein
MQRRLWQRGRPATAVALTALLVNTLVTAAYADPERGRPTPSPTPPTSQTPPALTPADGSYLEGTVKVAAVPATAGDSVTKLAVDGAAIEGATRTVGVSKLAFDVGSNSTEAQYHSYVLVNGAYKVEIGNYVSQRATLDIPNEHLVKGENTVEIVVGAIQSSCGTNYDDFVLSDVGLELLGEIADGEDNPYTLSFGDGSCGTNTTLLKRATLTFFTQSDPQGTTGLAADVDTTKLSNGPHVLSATTAAGVTVKHNVTVNNAPAGAPRLLPTDGTLVAGTKAVFATVPAGSAGGVRKLTVDGAAPVTKATLGNGAAMLAFDVGADALDDKYNNFLLVNGKRIDLGGSYVNGRATVAVPARFLIPGDNTIKVVTGDYKEACGTDRDDFTLSNLALTLDGATVTGQGVEASYAMGDGTCGSDTAAKREVELRYTIDAPAVHLVETLGSGEAKLSFNVGSNSIEARYQSYLLVNGQKVIVDGDFVSKRVDLTIPNEYLVPGWNTIDFVAGTYPTSCGNNRDDYAISNIALTPAQGTATGQMLKSSYSMGDGNCGDSVNPLTEIDLEFLVAAPAGGLRADLDTTAIKDGKHTLAAESSGGERATRTLITDNSAPKVTRSVPAAGEKIRATVVLDVRLEDASGVVTGPEVKLDGQPVALGAQVGPGLKAGRHTLSVSGSDGLGNAATREIVFESAGIPDVPSELSPALGAVDVSDPATLSAKVAEPDSGPVTATFSQAEILTPNEVYQGTATTLPTTLQVPGEKKVRARGLEPADGQTLDAPSGQDLVYQRFDVQVKGHADDPVLRWEGSIDPERLASLRVWNTKAKAWDLLTSSRGAPAGKTALTAVVDPAYIDRQKVHVMVTAEDPFADDIEPGDPNGFADPATYDFSIVHFTDTQYISEGAVEQETAEERAVWESAYAGIVNWIKDNKDQRKISYVAHTGDIVENNIRKPADEATQRQVVGEFEVSSKQQRVLDDAGIPNGVIAGNHDNQSGTEDGPGAIYNQYYGPSRYRTAAQGWQHAEYGGPWKEGDNQNHYDLFSAGGLDFVVVGLSYGVTRDEAEWADSIFKKYPNRNGILLSHDYLVPSTNPDGRGAGFSAPDGSMLYKTVVEKNPNVFLILAGHEHGVGTNVKPKVGQVGNGVVELLADYQFYTVSADRLGLTEIGGYNPQDQLQFGASFLRMLQFDVKRSELSVDTFSPLLGEFGATEYDPLRRYNGIEDNMVLPVDLTSRTTSLQTDSLAIYKPTRVIGRDRVASGQVASVTWDRLKDDTAYAWFVTARSAGGGVTASEPSVFVTKDEHGRPGRWDADSPMHRWFNR
>NZ_CP017717.1|WP_080046020.1|12553438_12554545_+|HupE/UreJ-family-protein
MLRWLPVFVVLAALLLPAPAAAHDATTTARAEVTGTGTDVRVVLDLEYDLLMKSAWLYASAYDARERAEQLRQLKLNRDAVVEYVTERFAVTYDDRPCAPTLTRDADVRPQDRKTFAVLTFTFACQGGPGGTHAISSALFPDAETFVHSTETLVRYDLDGERGSAVLVAESPTLKVGERARSDQAGEFFLLGAEHLLTGLDHVLFLLALLIGARRLRDVVVTATAFTAAHSITFLLAALGLVDVPGAIVEPVIAASIIVVATANLLGRDEDRLGRRRLPIVLAFGLVHGLGFAGALDIDRSGSWELLLSLLSFNAGIEATQLALIAVLFPLLTLLRRTPWARWAMAGLSVPIVGVSLYWLVERLPLPL
>NZ_CP017717.1|WP_155130168.1|12554687_12555992_+|HAMP-domain-containing-histidine-kinase
MLLLNVVVSAFVLFGIRNEVADIRAREVTSKSVRVLLMVKRNRLPQVLPDHGLDGVQVVNPRGRPVAWTRGLAGAPRLTTEIPHHDQANEVARLCDLPRFPGTCKTVVVLVAYQPEGEWLIYGVGPAVPWYVAPQVIAFQAVVTAALVVLTWFGVSRVVARTLRPVGGITKRLAEISEGGGGMRVPVPETDDEIRALAETSNRTLERLESALQRLQEAMERQRQFAADASHDLRSPITAMRAQVEDALLHPEDADWPETGAEVLASLERLQAIVTDLLTLSKLDAGAPDEREPLDLADLVTAETARPRSKRIVTTLQTGVVVNGDRLQLARLLTNLLDNAERHAESQIIVTLRRQGDEAVLEVVDDGTGIAPEHREKVFERFTRLDASRSRDAGGTGLGLPIAREIATAHLGTLTIEDSDTGARFVLRLPVQED
>NZ_CP017717.1|WP_080046021.1|12556012_12557215_-|hypothetical-protein
MTFNPLQERGIPLDKQLRNWRELNVTPTDPDHADPYTRCRIITMNGIEVEAILFSHQLARHCPDLELKQHLARVRYIEAQQQKVVNWLLPGLASVLETTIAYEQVAVDLTAWVARMEPDPYLQQAYQFGVLEDFDHLYRYANLYEMIEHRKAEKIVDNLTEVMPGRPTYLHHRDPVDNVREPYDKSSAAPISKLHALTIMSAEQQTMNFYMNVGPTYMEPIARQLYQEIGLIEEEHVTHYESLVDPGESWWEMLLNHEYNECYLYHSFMETESDPKVKNIWELHLNMELEHLRLAAELFKKHDGRDPEQVCAPELPQPVTFEPNKAYLRELIATQIDYTTLGTGYVQDAHERFEKMQEALMGGEKAPSERVIEDNRAKSGEEYRLQTEGDHPVHSLQMQR

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Crispr_ID: NZ_CP017717_41

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_41

12613161-12613316

Orphan

Consensus_repeat	Method
GACGCCTCCACCACCC-CGCAGGCCGACGAGCCCGCCACCGAGCCCGCA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017717_41

>merge|NZ_CP017717|41|12613161-12613316|PILER-CR
GACGCTTCCCCCATGCCGCAGGCCGACGAGCCTGCGACGGAGGCCACCGAGACCTCTGCCGCCCCGCAGGCCGACGAGCCCGCCGCCGACCTCGCAACGGAAGCCGCGGACGCCTCCACCACCGCCCAGGCCGACGAGCCCGCCATCGAGCCCGCA

>NZ_CP017717|41|4|12613161-12613316|PILER-CR
GACGCTTCCCCCATGCCGCAGGCCGACGAGCCTGCGACGGAGGCCACC	GAGACCTCTG
CCGCCCCGCAGGCCGACGAGCCCGCCGCCGACCTCGCAACGGAAGCCG	CGGACGCCTCCA
CCACCGCCCAGGCCGACGAGCCCGCCATCGAGCCCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046066.1\|12608159_12609005_+\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|239507
NZ_CP017717.1\|WP_080046072.1\|12618166_12619591_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP017717.1\|WP_080046068.1\|12610226_12611240_+\|agmatinase	unknown	unknown	gnl\|CDD\|212516
NZ_CP017717.1\|WP_155129342.1\|12617192_12617372_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214750
NZ_CP017717.1\|WP_080046067.1\|12609129_12610200_+\|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|376752
NZ_CP017717.1\|WP_080046073.1\|12621468_12621957_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046071.1\|12617442_12618009_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP017717.1\|WP_080046070.1\|12615544_12617167_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|206743
NZ_CP017717.1\|WP_080046062.1\|12603680_12604238_+\|lactate-utilization-protein-C	unknown	unknown	gnl\|CDD\|224473
NZ_CP017717.1\|WP_080046065.1\|12606913_12608089_+\|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase-CbiE/decarboxylating-cobalt-precorrin-6B-(C(15))-methyltransferase-CbiT	unknown	unknown	gnl\|CDD\|381171
NZ_CP017717.1\|WP_080046076.1\|12625370_12626666_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP017717.1\|WP_080047596.1\|12605267_12605675_-\|DUF2795-domain-containing-protein	unknown	unknown	gnl\|CDD\|378655
NZ_CP017717.1\|WP_080046075.1\|12623388_12624561_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|236092
NZ_CP017717.1\|WP_155129339.1\|12605634_12606834_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP017717.1\|WP_080046063.1\|12604241_12605264_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376263
NZ_CP017717.1\|WP_080047598.1\|12619617_12620469_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NZ_CP017717.1\|WP_155129345.1\|12620432_12621533_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NZ_CP017717.1\|WP_080046061.1\|12602302_12603694_+\|lactate-utilization-protein	unknown	unknown	gnl\|CDD\|224062
NZ_CP017717.1\|WP_080046069.1\|12611319_12612552_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169
NZ_CP017717.1\|WP_080046074.1\|12621981_12623322_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080046066.1\|12608159_12609005_+\|sirohydrochlorin-chelatase	gnl\|CDD\|239507	cd03414, CbiX_SirB_C, Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase, responsible for the chelation of Co2+ into sirohydrochlorin, an important step in the vitamin B12 biosynthetic pathway. CbiX often contains a C-terminal histidine-rich region that may be important for metal delivery and/or storage, and may also contain an iron-sulfur center. Both CbiX and SirB are found in a wide range of bacteria.	9.84843e-36
NZ_CP017717.1\|WP_080046072.1\|12618166_12619591_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.49036e-47
NZ_CP017717.1\|WP_080046068.1\|12610226_12611240_+\|agmatinase	gnl\|CDD\|212516	cd09990, Agmatinase-like, Agmatinase-like family. Agmatinase subfamily currently includes metalloenzymes such as agmatinase, guanidinobutyrase, guanidopropionase, formimidoylglutamase and proclavaminate amidinohydrolase. Agmatinase (agmatine ureohydrolase; SpeB; EC=3.5.3.11) is the key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield putrescine and urea. This enzyme has been found in bacteria, archaea and eukaryotes, requiring divalent Mn and sometimes Zn, Co or Ca for activity. In mammals, the highest level of agmatinase mRNA was found in liver and kidney. However, catabolism of agmatine via agmatinase apparently is a not major path; it is mostly catabolized via diamine oxidase. Agmatinase has been shown to be down-regulated in tumor renal cells. Guanidinobutyrase (Gbh, EC=3.5.3.7) catalyzes hydrolysis of 4-guanidinobutanoate to yield 4-aminobutanoate and urea in arginine degradation pathway. Activity has been shown for purified enzyme from Arthrobacter sp. KUJ 8602. Additionally, guanidinobutyrase is able to hydrolyze D-arginine, 3-guanidinopropionate, 5-guanidinovaleriate and L-arginine with much less affinity, having divalent Zn ions for catalysis. Proclavaminate amidinohydrolase (Pah, EC 3.5.3.22) hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Activity has been shown for purified enzyme from Streptomyces clavuligerus. Clavulanic acid is the effective inhibitor of beta-lactamases. This acid is used in combination with the penicillin amoxicillin to prevent antibiotic's beta-lactam rings from hydrolysis, thus keeping the antibiotics biologically active.	1.0949e-114
NZ_CP017717.1\|WP_155129342.1\|12617192_12617372_-\|hypothetical-protein	gnl\|CDD\|214750	smart00633, Glyco_10, Glycosyl hydrolase family 10.	0.00206967
NZ_CP017717.1\|WP_080046067.1\|12609129_12610200_+\|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	gnl\|CDD\|376752	pfam02277, DBI_PRT, Phosphoribosyltransferase. This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.	7.30488e-151
NZ_CP017717.1\|WP_080046076.1\|12625370_12626666_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.19409e-63
NZ_CP017717.1\|WP_080046071.1\|12617442_12618009_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	4.26667e-12
NZ_CP017717.1\|WP_080046070.1\|12615544_12617167_+\|ABC-transporter	gnl\|CDD\|206743	cd11383, YfjP, YfjP GTPase. The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.	2.51318e-33
NZ_CP017717.1\|WP_080046062.1\|12603680_12604238_+\|lactate-utilization-protein-C	gnl\|CDD\|224473	COG1556, COG1556, Uncharacterized conserved protein [Function unknown].	2.66542e-33
NZ_CP017717.1\|WP_080046065.1\|12606913_12608089_+\|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase-CbiE/decarboxylating-cobalt-precorrin-6B-(C(15))-methyltransferase-CbiT	gnl\|CDD\|381171	cd11644, Precorrin-6Y-MT, Precorrin-6Y methyltransferase (also named CbiE). CbiE (precorrin-6Y methyltransferase, also known as cobalt-precorrin-7 C(5)-methyltransferase, also known as cobalt-precorrin-6Y C(5)-methyltransferase) catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. It participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. CbiE functions in the anaerobic pathway, it is a subunit of precorrin-6Y C5,15-methyltransferase, a bifunctional enzyme: cobalt-precorrin-7 C(5)-methyltransferase (CbiE)/cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (CbiT), that catalyzes two methylations (at C-5 and C-15) in precorrin-6Y, as well as the decarboxylation of the acetate side chain located in ring C, in order to generate precorrin-8X. CbiE and CbiT can be found fused (CbiET, also called CobL), or on separate protein chains (CbiE and CbiT). In the aerobic pathway, a single enzyme called CobL catalyzes the methylations at C-5 and C-15, and the decarboxylation of the C-12 acetate side chain of precorrin-6B.	7.24134e-32
NZ_CP017717.1\|WP_080047596.1\|12605267_12605675_-\|DUF2795-domain-containing-protein	gnl\|CDD\|378655	pfam11387, DUF2795, Protein of unknown function (DUF2795). This family of proteins has no known function.	1.05146e-13
NZ_CP017717.1\|WP_080046075.1\|12623388_12624561_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	6.90587e-22
NZ_CP017717.1\|WP_155129339.1\|12605634_12606834_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.13854e-28
NZ_CP017717.1\|WP_080046063.1\|12604241_12605264_-\|hypothetical-protein	gnl\|CDD\|376263	pfam18844, baeRF_family2, Bacterial archaeo-eukaryotic release factor family 2. Bacterial family of the archaeo-eukaryotic release factor superfamily. Likely to play roles in biological conflicts or regulation under stress conditions at the ribosome. This family contains a well-conserved 'FP' motif in the catalytic loop.	8.07516e-36
NZ_CP017717.1\|WP_080047598.1\|12619617_12620469_+\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	5.74361e-58
NZ_CP017717.1\|WP_155129345.1\|12620432_12621533_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.00776e-38
NZ_CP017717.1\|WP_080046061.1\|12602302_12603694_+\|lactate-utilization-protein	gnl\|CDD\|224062	COG1139, COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion].	0
NZ_CP017717.1\|WP_080046069.1\|12611319_12612552_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	4.79213e-101
NZ_CP017717.1\|WP_080046074.1\|12621981_12623322_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.01806e-91

>NZ_CP017717.1|WP_080046069.1|12611319_12612552_+|uroporphyrinogen-III-C-methyltransferase
MGPYLLGLRLSGRRVLVVGGGRVAQRRVPALLEAGAEVTVVSPSVTPALDDLIAAGRVTWHARPYEVGDCDGAWLVQACTDDRSVNTAVAAEAEAKRVWCVRADDKDASAAWTPATGRVDEISVAVTAGGDPRRAAGIRDAVVEALRDGTVDARRNRTKPVGVALVGGGPGDPGLITVRGRQLLAQADVVVADRLAPRALLDELAPDVELIDAAKVPYGRALSQETINELLVDRARQGKFVVRLKGGDSFVFGRGGEEMIACAEAGIPVLVVPGLTSAVAVPAAAGVPVTHRGVSQEFHVISVHVAPDDPKSTVDWPGLARSQGTLVLLMAVERLAKVAEALVRDGRPPETPVMVVQDGTLPTQRAVTASLSTVADRVSAAGIRPPAIVIVGDVVRVGQEVEMVRAERLP
>NZ_CP017717.1|WP_080046068.1|12610226_12611240_+|agmatinase
MSRYGPMYGPDITFLGVDRCDVNDPESYAGADVVIIGAPFDGGTSNRPGARFGPMALRQACYLPHDGSRPSLALRVDALRDLRVLDAGDVECYSGDVEGSLAAIEEAVHRVAASGAVPLVLGGDHTVALPDARGTARAYAAGRTSMIHFDAHADTGDIAFGHLYGHGQPMRRLIESGAIRGDRFLQIGLRGYWPEPETLGWMARQKMRSYEMTEIVARGLDECLTESFSIALDECDQIFLSVDIDVCDPGHAPGTGTPEPGGLTARQLLDAVRRICYEMPVAGMEVVEVAPPYDHADITAYLGNRVILEALSAMARRRKDDEGGPRWDPRQPLLDGR
>NZ_CP017717.1|WP_080046067.1|12609129_12610200_+|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase
MFAETLAAIRRADPRVLAEARAHQDRLTKPRGSLGALEEVAVRLAGAAGTTPPPMPEPAALAIFAADHGVHARGVSPWPQEVTVQMVANFLAGGAVANAFAAQAGASVTVVDVGVAADLPDAPGLVNHKIAYGTADLSQGPAMTVDQAVQALEAGIVVARDLVAKGARCLITGDMGIANTTASAALVSAFTGKDPAEVTGRGTGIDDETYELKVGIVRAALRANAVTDPASSPSETLRALAAVGGFEHAAIAGFILGGAALRVPVILDGVIAGAAALVAAAFDPAAVDHCVAGHRSAEPGHTAALAHLGLRPLVDLELRLGEGTGGLLAHPMVCAAVRVMHDVATFDSAGVTEKPV
>NZ_CP017717.1|WP_080046066.1|12608159_12609005_+|sirohydrochlorin-chelatase
MKPPLLLIGQSSQDDAYAAEFGRFVHRLRCRLDQSGADVSGGYLERATPRLSDSVASLVARGHHRLVALPLSLSRVGEEFPAAMALEQQRHPTLMYDYGRPLGPDPRVLALLAERLNEAATELSRPRALELAGARPRLRAVDSPPAEDLHQHIEPGETAVVLVGEGSTDAAANAEVHRVSRLFWETHAYDFMTVETAFVSVTPPGVPGGLERCRRLGAKRVIVVPYLLFAGGLLERVWAQALAYGAGHPDLDIRCAEVIGDCETLADVVIDRYEEALQLVP
>NZ_CP017717.1|WP_080046065.1|12606913_12608089_+|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase-CbiE/decarboxylating-cobalt-precorrin-6B-(C(15))-methyltransferase-CbiT
MITVVGWDGSELSAKAVGKLREAKLVVGPDAVLGQLGLTAATAADGALLEALDDHLEHGEGPAVVVAPGDPGFFGVVRTLRAHGLKPDVLPATSLVTRAFACAGLNWEDALVVAPSGPRQLDRVVNACRAHPKVALLVAPGVGPAEIARELAPTTPRALIVCEDLGGPDERVTHSRMGEATTRPWKDPDVVLVIDPLHQPKEPSWVAGARPGPSEWALPSADGMPAEARAYVLAKLGPRLGDLVWDVGAGTGQIAVECARLGAAVVAVERDEERCAKLRAHVLEHGVKVALTRGQAPPALEPLPDPDAVFVGGGGLDVIVACAARGPRVLVCALRKVEHVAGVLDRLREHGYRGEGTQIQVSKLLLNPDGSHSLAAVDPVFVVHATPAHAA
>NZ_CP017717.1|WP_155129339.1|12605634_12606834_+|GNAT-family-N-acetyltransferase
MSRRGPCLSLPRSIIQATLLSIRPYPRFRGQTSRLCTLHTVFDPDVSIATERLTLRPFGPKDTLRIRSIVQSGAQFLPPGAPARVSGIAPWLMHGVHELRRSGQGIHLAMTDAEGVIVGAISLFKTSWSAGTTEVGYGVHPLYRGRGFATEAVRGLTAWAFDTMGLRRIDLTARLDNLASLRVATKAGFTWEGVVRDAVVDDDGAHDLVLFGLLHYDSRVPPATLSKAELRTQRLLLRRQRPEDAADLAVTGADPLTQRFTGVPRDYSAEHARAYVAHAERRWIRGVGVAWTAAELATGRYAVNVDLRDLDWNGRTAEVGYMTAPWARGRGYAGEAVQAVARWLFERHGFSRLQLRVSPANNASQRVAEKAGFVREGLARASIAGEDMIVYSLIPSDLA
>NZ_CP017717.1|WP_080047596.1|12605267_12605675_-|DUF2795-domain-containing-protein
MERGSDKHGPRLDNEQKHETEGLVRGGGTTHAEEWKEPEAMPAPGEESLHSYPPGHEPGVPEGMTQRDVDVRSDLAKWLSDTHWPSSKRDLLARAQREGAPDPIIDMVESLPERDYTNMADVAKALGIGVEKRRW
>NZ_CP017717.1|WP_080046063.1|12604241_12605264_-|hypothetical-protein
MRLDFIRPLYERRGPYASVYLGALTGPERESHWRSVRDRLDGHSGHADEATLDALEEEALGAAAGRALFATHGDVVLAESLPEAPSELATWTPLPHVTPLLMRRGENIPHIRVIVDHAGAEVTVFGGGSPRSTTVEAASWPLQKTAQGGWSQKRYERAVDDAWEKNAQAVAKEIDEQVRRIGAELILVAGEPKSRSYLLHHLGTKAADRVMIVEHGSRDNHGQFEQDVERALDEWLDRRRAELLERHQESAGPTGMARVCQALREGRVHAVLLPGERPGPVWIGEGGTQLATDEGELRRWGVEEPIRERSDSALARAAAMTDAELWFTDAVEDVAAVLRY
>NZ_CP017717.1|WP_080046062.1|12603680_12604238_+|lactate-utilization-protein-C
MSAREEILARVRKAVAGAEDVEIPRHYRTNRQGEDLVGLFAERVDDYRAIVHVVPAAEVPGKLDACLGERRMIIPDGFDRAGGWDDVNTADGVVTGCAVAIAETGTIVLDHGPGQGTRAQTLVPDYHLCVVRADQIVAGVPEALARLDPARPLTWISGPSATSDIELNRVEGVHGPRTLEVIIST
>NZ_CP017717.1|WP_080046061.1|12602302_12603694_+|lactate-utilization-protein
MSATFLGMPGSFPKNSRKAVQNSQLRFNLRKATHTIRGKRAGVVGELPDWQELRAAGKAIKDHTLRNLDRYLLQLEEAVTRAGGTVHWARDAAEANRIVTDLVKATGETEVVKVKSMATQEIELNQALAAHGITAYETDLAELIVQLGDDFPSHILVPAIHRNRSEIREIFLDKMPHVPPGLTDDPPALAEAARLHLRERFLRSKVAISGANFMVAETGTLVVLESEGNGRMCLSLPETLISVVGIEKLLPSWRDLEVFLQLLPRSSTGERMNPYTSMWTGAVEGQDFHLVLLDNGRTDVLADEVGRQALRCIRCSACLNVCPVYERAGGHAYGSVYPGPIGAILTPQLRGMSSELDASLPFASSLCGACYDVCPVAIDIPEVLVDLRAKAPHAAAEKAGMKVAGWILNDHERLAKAQRAATRARKLVPKRLPGPLSAWTDTRDLPEIPEESFRDWWERNERA
>NZ_CP017717.1|WP_080046070.1|12615544_12617167_+|ABC-transporter
MTTTTTRPGLAARLTALTKVVELGPGRLDKKLLNESGALLQRAGNRLKLSSEHTVVALAGGTGSGKSSLFNALSGLELSPTGVRRPTTARTHACVWGLEGAGPLLDWLQIQWRHRFSRASALDKGDSQLHGLILLDLPDHDSIRALTDTEADRLIGLADLVVWVLDPQKYADASTHRRYVTELAGHEAVTVFALNQADRLTTEELAELVIDLNDLLRKEGVEHPSVVPTSAVTGRGIESLKSVIATAVARRRAAIQKLEADLHRLEQKLSQAMPLGEALSAPSTVDEARRMGLTDALCDAVGVPAVGEAMENVYAERSSRWVGWPYPRWVGKLRGDPLKSLRLDDVSEEIRGISTSSVSAQSAEVANAVQALADGLSMSMHPVWRTAVHQAARSRAGQLPQALTEDLAEVAPQLDRVPGWWRALKVWQYFLVVAFVAGLAWLAVGLLMPGQLPPSLELLGDTATLPWVGLMMASVLGLGALSGIASRNFVELGASRERERLEREMRRRVAAVAATMVVEPVERELGRHHAFYTALRDLSV
>NZ_CP017717.1|WP_155129342.1|12617192_12617372_-|hypothetical-protein
MIRTVAACAARLNVTHHELFGLRDADSGRDEPTARLGLTTSDYRPKPAYDVYRQLIAQS
>NZ_CP017717.1|WP_080046071.1|12617442_12618009_-|PadR-family-transcriptional-regulator
MPTTAVDNPLTLRLLGLLVEQPMHQYALAVALNERYPYLNAKSGSVYALVRSLQTAGWVTRTGVEQVGNRPTRTVYALTDQGWRVFRERVRRQLREARVTTSAFVDALAYLGALDRAEAPHVLRERLESLEERISELERAGGPGVKEITMIEVDFVLHQLHSEADWIRALITRIEDGELAWPAAEGRA
>NZ_CP017717.1|WP_080046072.1|12618166_12619591_+|MFS-transporter
MTTTTPLPATTGQAPSPQLTGRLRVVLAVLLVAQFMLAVDFSILNVALPAIGDDLGFSLGGLQWIATAFALCAAGFTLFFGRIGDLAGRKRIFLGSLALLGVASLAGGLAPTPEILILARVAQGLATAAATPAGLALLTTSFPEGPLRQKALGLNGALMSAGFTAGAVLGGVLTDLLSWRWAFLINVPVALAVLLAAPAVIAESRPAGRPRLDLPGALSVTLGLLGIVYGLTQAGEHGWTHPLALTGLLAGAALLVVFHRVERRAAQPLVPLHVLRRPTVAWGNLLGLLAFVTETSLVYLLTLYLQKTLGFSALAAGLSFGVLGLGTVAGGLLAPKVIARTSTATVLIGGGLLQTAATAVLLLMGGTSASMGLLLPATFLGGVGNMLVIVGFMVTATTGLPDHQQGLATGLASMSQQIGITMGTPIMSAIVTAAIGGVVTAGAVLHGVTVAIAVNAALVLSGVLIAALFLRPRA
>NZ_CP017717.1|WP_080047598.1|12619617_12620469_+|SDR-family-oxidoreductase
MDLQLTGKVILVTGATSGIGLAAARVLAAEGAHVVALARGHSTTVPPAPTGNAPASGGNAPAPAGDVLPAGTLLVRGDLTDPATPARAVAAIIDRYGRLDGLVNNAAALTSRDSFAAIDDEQWHATFELNLHAAIRMTRAALPLLESNPAGGAIVHVASEAARLPDPTIADYAASKAALLSVSKSLAAAYGPAGIRSNVVSPGPTRTALFDAPGGFADQLAHRFDLPPDQAVEHFVRVERRLPTGRIGTPEEVAGVIAYLLSPLAAQVTGAEWAIDGGARRQL
>NZ_CP017717.1|WP_155129345.1|12620432_12621533_+|alpha/beta-hydrolase-fold-domain-containing-protein
MGHRRRRPEAAVNTTTKPATPGPEPVVGPPPSWSSLVLPGAPPVPVRVHLPEGRAPAGLLVWAHGGSWQHGSAAEWHHTTTALAARSGWAVISVDYRLAPRHRHPSAVQDVLTALTWAHDGTPGTPLAVDGSRAGTPRAAGGSRAGNPRAAGGSRAGTPRAVGGDRAGIPLAVGGDSAGGTIAAVAALAARDRGLPLVAQVLAYPPFDPDCAAPSYHRSPSAFPQAAALRGAWRAWLGDNTATTHDAAAPDIGGGTTADRTRLYATPWQAPTLEGVAPAILAVGRDDPVHDDVVTYARRLHADGVPARLLRPSGARHGDMLRPDRPLLHQLAAALRELTPSLEERNDHERRPCPTRGPRPPLHRPA
>NZ_CP017717.1|WP_080046073.1|12621468_12621957_+|hypothetical-protein
MTTNVAPAPLEALVRHFTDLRDGTHAGHTTREGKERAFHQAVTLLDAPARQVLAEFDHHLLLDTGTIETTGLVPDTTGGSFAAWSLSWPAQRAAGIAPITLTAHYGAGFHHPHLRGATVGEWPLNVMDARHAAELVPVLRAIAAADLHNLVFLRDWRIVPAI
>NZ_CP017717.1|WP_080046074.1|12621981_12623322_+|SGNH/GDSL-hydrolase-family-protein
MNLFFAVKTGTALTALLIALGTPATTTSPARAAAAVSVPAGVTSAQTDALRRQAEWRAGWRAAWMAAPQRASTGFEPNWSEEGFSGQSVRQIVRLTAGGSSLRIRLSNDYGPSPVHVTGATVAYAGQGASLQPGSVHRLTFNSTPSADLPAHGTLTSDPVRLRIEPFQSMAVTLYFAGTTGPATFHSQAYATSYRAQGDHATDTTATAFTQSTHSWYYLSRVDVTGGKDQQGKAVVTFGDSITDGFGSTNGANNRYPDELAEQLAARGASRPVLNAGIGGNLVLNDSAWYGDRSAARFRRDVLDQPGVGTVVILQGVNDIGFNESDTPTYKPAPVVSADELIAGHRRLIRQAHAKGIEVVGATLLPFKGSDHWGAHAAAVSDAVNEWIRTSGEYDAVVDLDRAMAAPDDPDVLNPAYDSGDHLHPNNAGYTAMARHITDKLTSTTK
>NZ_CP017717.1|WP_080046075.1|12623388_12624561_+|single-stranded-DNA-binding-protein
MPLPPPHPQNHVRPSPPPSHHGTVFTRPRAAGPPHGRHGMNDIYITLTGNVAAEPRQYSFDEGVKVTSLRVLTTHRYFDKRAGQWVDGEKVCFTVRCWRALGENVAASVRAGHPVVVSGKLRIREFGAEGDRRFMPEIEASAVGHDLRWGTGAFTKPERGGSGAVSKEMRDRLDEETRDWAMGPRPQRSLSRSPLREEPNPFHTSDDNEQPLTTVSATVGGSGAAENGTTAERGETARRGGTAERGETARHGETAERGVTAGHGETAERGETAEGGMTAYSGVIAEGGMSVENALRDLGGTVHTLVPDHAPAASATEGHSAEASGHHTLARGRDADVKGRGTNLKGRGPDVKGRGGNTKGRDAEARGRDTGTKAADGDDGHLTMAEKAAA
>NZ_CP017717.1|WP_080046076.1|12625370_12626666_+|GGDEF-domain-containing-protein
MAVTSHASIKSRDGVSTLADRWPLLGQRRPLVVYLCAIVTLDLAAIVTFSASTVFEWREALTFAALMGCGAVCIEASRRLGMPAGVSRDLLSAWWLPVALLLPPVYALFAPIVLQILLQVRVRATVVYRRVFSSAAIGLAGCSASFVFHGLVADPWALSQGGGRLILFAVASAVLFSLLNIALIAIAAHTANPDSAWREVLWDRESVLLDVVELCLGVTVSISCGLNLGLLILALPPVVLLQRSLLHAQLQAAARTDAKTGLLNAAAWQREADTEIVRARRTGDTLALLIIDIDHFKRVNDAHGHLVGDQVLVGVASMLRSQLRDYDVVGRFGGEEFVVLLPGADIDEARQVAERLRVRIGHMAIPVDDTLVRVTISAGVALMSVHGDDLIDLLTAADLALYRAKELGRDRVCIPAVQPPPRSLPNDPSTP

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Crispr_ID: NZ_CP017717_42

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_42

12882547-12882663

Orphan

Consensus_repeat	Method
GGGTGGGGGAGAGCGAGGCGAGCAGCGGGGGCGAG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017717_42

>merge|NZ_CP017717|42|12882547-12882663|PILER-CR
CGAGGCGAGCAGCGAGGGGCGAGACGGGGCGCGGGTTCGAGGCGGGTGGTGGAGAGCGAGGCGAGCAGCGGGGGCAAGCAAGGGTTGGGGGAGAGCGAGGCGAGCAGCGGGGGCGAG

>NZ_CP017717|42|5|12882547-12882663|PILER-CR
CGAGGCGAGCAGCGAGGGGCGAGACGGGGCGCGGGT	TCGAGGCGGGTGGTGGAGAG
CGAGGCGAGCAGCGGGGGCAAGCAAGGGTTGGGGGA	GAGCGAG
GCGAGCAGCGGGGGCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_155129397.1\|12875268_12876129_+\|DUF4111-domain-containing-protein	unknown	unknown	gnl\|CDD\|379178
NZ_CP017717.1\|WP_155129400.1\|12886653_12887502_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046260.1\|12866925_12869406_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP017717.1\|WP_080046271.1\|12887498_12887861_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227259
NZ_CP017717.1\|WP_080046273.1\|12888779_12889298_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046272.1\|12887950_12888730_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319
NZ_CP017717.1\|WP_080046275.1\|12893592_12894060_-\|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP017717.1\|WP_080047635.1\|12874108_12875122_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090
NZ_CP017717.1\|WP_043614619.1\|12883154_12883610_+\|transcriptional-repressor-NrdR	unknown	unknown	gnl\|CDD\|234774
NZ_CP017717.1\|WP_080046268.1\|12881709_12882021_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366664
NZ_CP017717.1\|WP_080046266.1\|12879586_12880294_-\|transcriptional-repressor-LexA	unknown	unknown	gnl\|CDD\|234688
NZ_CP017717.1\|WP_080046269.1\|12883606_12886429_+\|vitamin-B12-dependent-ribonucleotide-reductase	unknown	unknown	gnl\|CDD\|235828
NZ_CP017717.1\|WP_080046274.1\|12889328_12890156_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NZ_CP017717.1\|WP_080047636.1\|12876270_12876873_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238496
NZ_CP017717.1\|WP_080046276.1\|12894085_12894484_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377824
NZ_CP017717.1\|WP_080046265.1\|12877706_12878684_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|227311
NZ_CP017717.1\|WP_080046277.1\|12894520_12895732_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|238634
NZ_CP017717.1\|WP_080046261.1\|12869406_12870375_-\|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274645
NZ_CP017717.1\|WP_080046262.1\|12870424_12870865_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046263.1\|12870979_12874129_+\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|227282

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_155129397.1\|12875268_12876129_+\|DUF4111-domain-containing-protein	gnl\|CDD\|379178	pfam13427, DUF4111, Domain of unknown function (DUF4111). Although the exact function of this domain is not known it frequently appears downstream of the family Nucleotidyltransferase, pfam01909. It is also found in species associated with methicillin-resistant bacteria.	6.93929e-06
NZ_CP017717.1\|WP_080046260.1\|12866925_12869406_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP017717.1\|WP_080046271.1\|12887498_12887861_-\|hypothetical-protein	gnl\|CDD\|227259	COG4922, COG4922, Uncharacterized protein conserved in bacteria [Function unknown].	1.55016e-20
NZ_CP017717.1\|WP_080046272.1\|12887950_12888730_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	3.10842e-24
NZ_CP017717.1\|WP_080046275.1\|12893592_12894060_-\|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	7.41739e-22
NZ_CP017717.1\|WP_080047635.1\|12874108_12875122_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	1.18278e-97
NZ_CP017717.1\|WP_043614619.1\|12883154_12883610_+\|transcriptional-repressor-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	7.65393e-84
NZ_CP017717.1\|WP_080046268.1\|12881709_12882021_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|366664	pfam01476, LysM, LysM domain. The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.	3.62133e-08
NZ_CP017717.1\|WP_080046277.1\|12894520_12895732_+\|amidohydrolase	gnl\|CDD\|238634	cd01309, Met_dep_hydrolase_C, Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	2.40283e-145
NZ_CP017717.1\|WP_080046269.1\|12883606_12886429_+\|vitamin-B12-dependent-ribonucleotide-reductase	gnl\|CDD\|235828	PRK06556, PRK06556, vitamin B12-dependent ribonucleotide reductase; Validated.	0
NZ_CP017717.1\|WP_080046274.1\|12889328_12890156_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	1.20877e-75
NZ_CP017717.1\|WP_080047636.1\|12876270_12876873_-\|cysteine-hydrolase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	8.13769e-53
NZ_CP017717.1\|WP_080046276.1\|12894085_12894484_-\|hypothetical-protein	gnl\|CDD\|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	1.71601e-24
NZ_CP017717.1\|WP_080046265.1\|12877706_12878684_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	3.22001e-88
NZ_CP017717.1\|WP_080046261.1\|12869406_12870375_-\|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274645	TIGR03557, F420_G6P_family, F420-dependent oxidoreductase, G6PDH family. Members of this protein family include F420-dependent glucose-6-phosphate dehydrogenases (TIGR03554) and related proteins. All members of this family come from species that synthesize coenzyme F420, with the exception of those that belong to TIGR03885, a clade within this family in which cofactor binding may instead be directed to FMN. [Unknown function, Enzymes of unknown specificity].	1.44061e-170
NZ_CP017717.1\|WP_080046266.1\|12879586_12880294_-\|transcriptional-repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	1.12377e-108
NZ_CP017717.1\|WP_080046263.1\|12870979_12874129_+\|S41-family-peptidase	gnl\|CDD\|227282	COG4946, COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown].	4.90897e-106

>NZ_CP017717.1|WP_080046268.1|12881709_12882021_+|LysM-peptidoglycan-binding-domain-containing-protein
MRLTRRGRVVLVMAVALLSLGGFWLGTRAAGHAEVRVVVASHAGLPWVEVHKGDTLWEIADALSEGDDPGALVEEIKRLNRLSDSLIRPGARIYVPRDTAALR
>NZ_CP017717.1|WP_080046266.1|12879586_12880294_-|transcriptional-repressor-LexA
MTERDDANGVSDLAVRRRDSLGLTPRQRKILEVIRDSVQQRGYPPSMREIGEAVQLTSTSSVSHQLTALQRKGYLRRDPHRPRALEVRLPGEPVLWVDPDATDEEPTVNRPTAAYVPLVGRIAAGGPILAEESVEDVFALPKQLVGEGTLFLLQVAGDSMIEAAIADGDWVVVRQQPVAESGDIVAAMIEGEATVKTFKRKDGHVWLVPHNPNYEPIPGDEASVLGKVVAVLRRL
>NZ_CP017717.1|WP_080046265.1|12877706_12878684_-|helix-turn-helix-domain-containing-protein
MPASHRVIVAVFPDVDLLDVTGPAEVFAVANREMDGRVPYEVLLAGPDGGQVRTSAGVRLATDLTFDEVGDRVDTLVVPGAVDAAGVPVIDSRLVGWIAETSEHARRVASVCVGAHLLAAAGLLAGRTATTHWATAERLAADHPDVTVDPDPIYIRSGKVWTGAGISSCMDLALALVAEDHGERLALAVARQLVMYLKRQGGQSQFSVPLWQAPTERRDIDELRVWITANLTADLSAAALAERVCLSERHFARVFRKETGATPAAYVEAARVEAARRLLEGTDEPLDRVAAACGLGSAETLHRAFRRRLGTTPATYRRRFRTAAA
>NZ_CP017717.1|WP_080047636.1|12876270_12876873_-|cysteine-hydrolase
MSVSTTLRDVIGLDRELPRLSTATLVLIDFQNTYCEGVMALPGADRALDAAARLLERARAAGTPVVHVINDGGEGTPYDIRAEIGQIEPRVAAREGEAVVVKGFPNSFHETDLLETLRKLDAGPDLVLAGFMTHMCVQFTAQGAFNLGYRPTVVAEACATRPLAAPGGEPISAEQLHAAALTTIGDLFGLVAARVDDLPA
>NZ_CP017717.1|WP_155129397.1|12875268_12876129_+|DUF4111-domain-containing-protein
MASWAAMTPHPKIAAIVETYLSLADAEAPGLVEGLYLEGSAALGDYRPGTSDVDFVAVTSALPPADVLERIHTKLGAHPFDGVYLTWDDLGHDPTGLGERPQAHAGRLNRRGTVNPVTWHTLARHGLTCRGPKPEDLKIWNDPEALAAWTDRNLDLYWRRLVIRASRPLTPWGLACLGPYGTVWVVTGVARLHYTLATGEIISKSGAGRHARETFPERWHRVIDEALRLREEDTAVPSMAGVIAGLGDHFGTPRRSLYGSPFERKRDVLGFADEAITAAHELYRTR
>NZ_CP017717.1|WP_080047635.1|12874108_12875122_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MDLPTAPAVADVLRRRADGDLGYPAWLLDRNAGPLAEAFAERMAGRFGWEADPGLVRPFNDLNQALQVLLHLWTKPGDGVAVHVPAYHPFLDTLDVMERPLRPIRMEPDGDTWRFEVPDLAGCRVLLLVNPHNPTGRAFTERELTELAEHAERHDLLVIADEIHADLVYEPHRHIPFATIAPERTVTLTSATKAFNLGGIRCSVAHFGHEGARTALEAQPPFVYGSPSVFGVEATVAAWRHGDAWLAETVALLDRNRRTIADRLPAAFGYRVPEATYLAWLNVGRPGMAEVFEREARVRLNDGAAFGPGGESCVRLNFATTEAILAEILDRLLRQRW
>NZ_CP017717.1|WP_080046263.1|12870979_12874129_+|S41-family-peptidase
MAYGAYLRYPHLHGDLVTFVADDDVWLAPVTGGRAWRFTADRVPVSNPRFSPDGGRIAWTSTKEGAPEAFTAELDGPEGERLTHWGDRATSVRGWLGDGEVLAVTAAGQGSDNRRWAHAVPLDGGPPTRLPYGWVGDAAVSDGRVATVSVIWTEPSHWKRYRGGTAAKIWVDADGSGEFTRLFADDPAQHWAVSWVGDRLVFTSDTDGVGNVYSALPDGSDLRKHSSHDEFYARHATSDGQRVIYSHAGDLWLMESLDAEPYRLDVRLGGPRPGRARRPAPLRAGGFSPDATGRASAVEIRGTAHWVTHRDGPAGVLRAEPGVRVRLPQVLDADGKAVWVSDASGEDGLEIGTPGGEVRTLAAGQLGRVLELVAAPDGKHVAVATHDGRLLVIDLDSENVRELEHTDQGDVSGLAFSPDSTWLAWEHPHHRRLTQIKMGRVDGTSVIEVTPPRFVDYDPAFTKDGKHLAFLSVRTFDPVYDAHVFDLSFPQGCKPYIVPLKADTPSPFDPSLQGRGFNGEDDKPSKDDKKDDMPPRTEVDPDGLAARVVPVPVPAASYGNLRTAKDALLWLRHPLSGVLGDGSEQTSETVLERYDLKKRAKAELGKEIRAFEVSGDGSRLVTNGKNGLQTRAASEGDEVVTVDLDRITVHIDPVAEWRQGFREAGRLMRDHFWREDMNGVDWQGVLDRYEPLISRIGAHSELIDLLWETQGELGTSHAYAVANGSGTDPRRRQGLLGADLVRDDEGVWRVGRILPGESSDHAARSPLLAPGVAVREGDAILAVGGRPVDPVRGPLPLLAGTANQPIELTVRHSSGGDVRRVVVTPVADETQLRYHAWVDDRRAYVRQASGGRLGYLHVPDMVASGWAQFHRDLRTEMDHDGLVVDVRENGGGHLSELILEKLSRKVTGWARARWYQPMRYPDDSPRGPVVTVADEFAGSDGDIVSAGIKARGIGPLVGTRTWGGVIGIDSRYSLVDGTRVTQPRYSFWLDGPGWGVENHGVDPDVEVVITPQDRVAGRDPQLDKAIELALAALDERPAAAPPDLPPLAQ
>NZ_CP017717.1|WP_080046262.1|12870424_12870865_-|hypothetical-protein
MKIFARPHQLPPRVSAAAIILNSGLDLIHADEQRAAATHGMAAGAYPFLRRMDPALFTRLLARSQVALGAALLAPFVPSLVAGAALTGFAAGLVGLYLRTPGMREEGSLRPTPQGLGVAKDVWLLGIGLGLVAEELRDRQLPGRQH
>NZ_CP017717.1|WP_080046261.1|12869406_12870375_-|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase
MVQIGYTLMSEQTPARELVDYAAAAERLGFDYAVISDHYFPWVEEMGHSPYCWSVLGAAAQVTERLPLMTYVTCPIMRYHPAVVAQKAATMGVLSQGRFTLGLGAGENLNEHVIGEGWPPVDTRHRMFAEAVQIIRKLFTGEYVTHQGEFFDVDSAKLYDLPEQPVPIGIAASGGQSAELAAEYGDVLVINEPMPEVVQQFNAAGGAGKPVYGQLALSYDTDAEAAKQRAHELWRWSSVGGWKVMAELPGPVNFAAAAGTVRPEDVAQSVPCGNDVDAVVQGVKKYVDAGYTHVALVQIGHDQQQPFFDWAEKELLPALRGL
>NZ_CP017717.1|WP_080046260.1|12866925_12869406_+|leucine--tRNA-ligase
MGPNQARRTVAVSEYDPQALQAKWQQRWEEQETYRASEDPADPRERRYMLDMFPYPSGDLHMGHGEVFALGDVVARYWMQKGYNVLHPIGWDSFGLPAENAAIKRNAHPAEWTYANIETQANSFRRYGISFDWSRRLHTSDPDYFRWNQWLFIRFFERGLAYRKGGLVNWCPNDQTVLANEQVVAGKCERCGADVIRRELTQWYFKITDYAQRLLDDMEQLTGWPERLLTMQRNWIGRSEGADVLFEIEGRDEPVHVYTTRPDTLYGATFFVVAADAALADEIVTDEQRPAFEAYRAEVAKLSDIERLATDKEKTGVFLGRYAINPVNGERIPVWAADYVLSDYGHGAIMAVPAHDQRDLDFARKFDLPVKVVVHTGLADPGETGEATPGEGTLVNSGPLDGLTKTEAITKIIEILETQGRGTGAVNFRLRDWLLSRQRYWGTPIPIIHCPDCGEVPVPDEQLPVTLPDLRGEALAPKGVSPLASATEWVNVECPKCAGPAQRDTDTMDTFVDSSWYFLRYCSPGYNDGPFDPEQVRKWGPIDQYVGGIEHAVLHLLYSRFFTKVLHDMGMVDFTEPFQRMLNQGQVINGGKAMSKSLGNGVDLGQQIDDFGVDAVRLTMVFAGPPEDDIDWADVSPAASQKFLARALRVMSEVTSEPGVAFDGGDTELRKVTHHTIDEATKLIESQRFNVAVARMMELTSATRKAIDSGPGPADPAVREAAETLAVLLSLVAPYTAEEGWERLGRTGSVAFAGWPVADPALLVQESVTCVVQVAGKVRDRLEVSPDISEDELRALALASEKIAPYVQGMPRKVIVRAPKLVNIVP
>NZ_CP017717.1|WP_043614619.1|12883154_12883610_+|transcriptional-repressor-NrdR
MHCPFCRHPDTRVIDSRSTDDGAAIRRRRTCPECGRRFTTQETVLLMVSKRSGVTEPFSRDKVVAGVRRACQGRPVSEDSLAQLGQRVEEAIRAKGAAEIPSNEVGLAILGPLRELDEVAYLRFASVYRGFESLADFEAEIKQLKAEKGES
>NZ_CP017717.1|WP_080046269.1|12883606_12886429_+|vitamin-B12-dependent-ribonucleotide-reductase
MTETASGSVARGGKRPRKGLKMKRIFTKPGVHPYDEIQWERRDVVMTNWRDGSINFEQRGVEFPDFWSVNAANIVTTKYFRGAVGTPQREWSLKQLIDRVVGVYTRTGLEHGYFASEEDAEIFDHELKHALAHQVFAFNSPVWFNVGTQSPQQVSACFILSVDDTMESILDWYKEEGVIFKGGSGSGVNLSRIRSSKELLSSGGTASGPVSFMRGADASAGTIKSGGATRRAAKMVVLDVDHPDIEEFIETKAREEDKVRALRDAGFDMDLGGKDIVSVQYQNANNSVRVSDEFMRAVEKGADFGLRARLTGEVIEKVDARDLFRKMAKAAWECADPGVQYDDTINDWHTTPETGRITASNPCSEYVHLDNSSCNLASINLLKFLKDDNSFNVADFVKLTELIITAMDISITFADFPTEKIGETTRAYRQLGIGYANLGALLMATGHAYDSDGGRAVAAAITSLMTGVSYRRSAELAGVVGPYDGYARNAEPHKRVMRKHAAANDDLRTIGTMDAKIHSEASRQWAECLKLGEKNGYRNAQASLLAPTGTIGLMMDCDTTGIEPDLALVKFKKLVGGGSMQIVNQTIPRALKQLGYQQEQIEAIVEYIGEHSHVVDAPGLRPEHYEVFDCAMGERAIAPMGHVRMMAATQPFLSGAISKTVNLPESATIDDIEQVYMEGWKLGLKALAVYRDNCKVGQPLSAGDGSKKQQEQPKEPEVKVIEVNRPTRRRMPNQRPSTTTRFTVGGAKGYMTASSYPDDGLGEVFLKMSKQGSTLAGVMDAFSVAISIGLQYGVPLETYMSKFVNMRFEPAGMTDDPDIRMATSVMDYIFRRLALDHLPYEERAALGIFSAAERAAQQRGEDPAALQETVDREALAQSAPIEAAAAQPKEESAQPAQELTLESHQRFTADAPLCMTCGTKMRPAGSCYVCEGCGSTSGCS
>NZ_CP017717.1|WP_155129400.1|12886653_12887502_+|hypothetical-protein
MRRGAGYGAAGSMGLYLVVKVGWVVAGLLGHPPDGFGTAGWVVLNAVTVVMAAAGIALGLALAQPWGRRLPGVPVVLVCWVGAGFLVPMLPYVLVSSLLEGEGVVRAEEALIGVGFGGMGVGLAVAVPIYLWERWPRAFAGDGPARSSTVITMGAVVAGGLGVLWVYWGMGGTLGLDRAFLDGHERLLNVSSGLWALLGAWSGWALTRRRPPWLRRWVPVVIGFAASGSLFAWSCWKLPMVLLRPGGFVSAEYAGVAVAEHVLGIAVGVTLLAAVLPSHEEG
>NZ_CP017717.1|WP_080046271.1|12887498_12887861_-|hypothetical-protein
MNDNKDIVLHGFKEFTAGNLGILRTLLREDFVEHSPGNPSGRDAWIEYTAGSPVAGARLDLKRIIAEGDLVMVHYHMIPAGDERGVAVVDIWRLVDGQIAEHWDVVQPVPEPDLIPNGMF
>NZ_CP017717.1|WP_080046272.1|12887950_12888730_+|helix-turn-helix-transcriptional-regulator
MRQDRPVGELLREWRHRRKLSQLDLAIQADVSARHVSFVETGRTIPSRSMVIHLAEHLGVPLRERNRLLVAAGHAPVYRERPLADPDLAAAREAVEQVLRGHEPFPALAVDSRWNLLLANAAAEVFLDGVDAALLEPPVNMMRLGLHPGGFAPRVRNLAQVRGFLVPRLARQVARTGDPELSALLEEVRQYGEEAGPVADAPTDIALPIRIEHRGRELCFFSTITTFGAAFDVTLEEIAVEAYFPADEQTARHLRKGVQ
>NZ_CP017717.1|WP_080046273.1|12888779_12889298_+|hypothetical-protein
MRRIAVLAVVFGALLYGVHRLAMVAVARLIGNQDMIVGLDCCIDYHRNAPDPWGNVLVAVSGVVATQVVAWVAIALLAARRGGPPRVPATLAVTAFVISPLLQLIVYAVWHWAERDYVAVIDYLMDATGLPEMALMAAMLGLFAGYAVIFWLGVRAAWDRATAVPAPVAPSS
>NZ_CP017717.1|WP_080046274.1|12889328_12890156_-|glycerophosphodiester-phosphodiesterase
MFRRLAVLIATSLTFLPLATATPADAATVINVAHRGASAYAPENTIAAFDLAAEQGADLFELDVQETKDHELVLMHDTTLSRTTNAEQVFPGLSPWNVGDLTLDQIRELDAGSWVSDKYEGERVPTLGEVLREMSGSGMGLLLEVKSPELYAGIESRIAAELRRHPSWLAPGRLVVQSFDWESMRRFDRLLPEVPIGLLGMPSTGDLPGLAKFADQINPPYTTLTASYVRRVHALGMKLLTWTVDGSSSMRRMIGYRVDGIITNRPDVLSDLLGS
>NZ_CP017717.1|WP_080046275.1|12893592_12894060_-|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase
MAENYGAEPAPQSLSDEELSGLLAEQRFGALATIKENGRPHLSTVRYAWDARHRVARISTIAGRLKVRQLQKDPRCSLYVAGDDFRAFAIAEGEAELSPVSLEAGDEVGLELLAMQPPFAGAEEEMAFLRQVVEDRRLVIRLRVSRLSGTSLPIT
>NZ_CP017717.1|WP_080046276.1|12894085_12894484_-|hypothetical-protein
MIADLYRRWLLELWNGDFALAYELVTPDFAGHWPGMEVSGPEGLAEALRQGHAPFDDVKVTLDVGPIVDGDLVSARWTFAGAYRGGLPGATAAPGTRIAFSGHDILRVREGRFAEYWVISDVQALNRQLGIG
>NZ_CP017717.1|WP_080046277.1|12894520_12895732_+|amidohydrolase
MNLAITSGYVVPVDGDPIDGGTVLIQDGKIAAVGRDVAVPEGTRVVDAAGAWVLPGFVEAHGHLGVHEEAEGWAGQDTNEMTDPNGARLRALDAINPADLAFGDALSGGVTTAVIKPGSGNPIGGQTVAIKCWGRSVDEMLVKEPVSVKSALGENPKRVYGDQKKLPSTRQGVAAVIRDAFMKAQDYKARRAAAEQEGKPFDRDGTLEILVRVLDGELPWCQHTHRADDIATALRLAGEFGYRLVINHGTEGHLLADTLAERNVPVIIGPLFTSRSKVELRHRSLRNPGILDRAGVELAITTDHPVVPIHFLVHQATLAVKEGLDPAAALRSITVNPARIMGLDDRVGALRPGLDGDVVIWSGDPLDVMSRALRVFISGREVYSYTDGEPVVADPYYRESSDR

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Crispr_ID: NZ_CP017717_43

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_43

12956054-12956163

Orphan

Consensus_repeat	Method
GCAGCGTCAGCGGCGGCACCAGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP017717_43

>merge|NZ_CP017717|43|12956054-12956163|CRISPRCasFinder
GCAGTGTGAGCGGTGGCATCGGCGTCTGGCATCGGCGGCGGGATAGCAGCAGCGTCAGCGGCGGCACCAGCAGCCCCTGCCCGTGCGGAGGGATCAGCGGCGGCACCAGC

>NZ_CP017717|43|36|12956054-12956163|CRISPRCasFinder
GCAGTGTGAGCGGTGGCATCGGC	GTCTGGCATCGGCGGCGGGATAGCA
GCAGCGTCAGCGGCGGCACCAGC	AGCCCCTGCCCGTGCG
GAGGGATCAGCGGCGGCACCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046325.1\|12963899_12964343_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046326.1\|12964339_12964867_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP017717.1\|WP_080046318.1\|12951209_12952103_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_CP017717.1\|WP_080046321.1\|12956297_12957413_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
NZ_CP017717.1\|WP_080046315.1\|12945338_12946160_+\|taurine-dioxygenase	unknown	unknown	gnl\|CDD\|181947
NZ_CP017717.1\|WP_080046317.1\|12948365_12951164_-\|protein-kinase	unknown	unknown	gnl\|CDD\|173871
NZ_CP017717.1\|WP_080047640.1\|12958419_12959832_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|335313
NZ_CP017717.1\|WP_080046329.1\|12967002_12968235_-\|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl\|CDD\|274452
NZ_CP017717.1\|WP_080046324.1\|12961311_12963834_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NZ_CP017717.1\|WP_080046316.1\|12946258_12948349_+\|RecQ-family-ATP-dependent-DNA-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP017717.1\|WP_080046313.1\|12939064_12942169_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|224389
NZ_CP017717.1\|WP_080046328.1\|12966128_12966623_+\|DUF3145-domain-containing-protein	unknown	unknown	gnl\|CDD\|378644
NZ_CP017717.1\|WP_080046322.1\|12957409_12958252_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP017717.1\|WP_080046320.1\|12955095_12955686_+\|phosphodiesterase	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046314.1\|12942431_12944936_-\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|235503
NZ_CP017717.1\|WP_080046327.1\|12964939_12965953_-\|S8/S53-family-peptidase	unknown	unknown	gnl\|CDD\|173787
NZ_CP017717.1\|WP_080046319.1\|12952259_12954938_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|131764
NZ_CP017717.1\|WP_080046312.1\|12938595_12938970_+\|glyoxalase	unknown	unknown	gnl\|CDD\|380093
NZ_CP017717.1\|WP_080046311.1\|12937994_12938561_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239267
NZ_CP017717.1\|WP_080046323.1\|12959918_12961304_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366708

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080046326.1\|12964339_12964867_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	3.47864e-22
NZ_CP017717.1\|WP_080046318.1\|12951209_12952103_-\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	3.38682e-65
NZ_CP017717.1\|WP_080046321.1\|12956297_12957413_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	2.02861e-32
NZ_CP017717.1\|WP_080046315.1\|12945338_12946160_+\|taurine-dioxygenase	gnl\|CDD\|181947	PRK09553, tauD, taurine dioxygenase; Reviewed.	5.92636e-90
NZ_CP017717.1\|WP_080046317.1\|12948365_12951164_-\|protein-kinase	gnl\|CDD\|173871	cd08506, PBP2_clavulanate_OppA2, The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold. Clavulanic acid (CA), a clinically important beta-lactamase inhibitor, is one of a family of clavams produced as secondary metabolites by fermentation of Streptomyces clavuligeru. The biosynthesis of CA proceeds via multiple steps from the precursors, glyceraldehyde-3-phosphate and arginine. CA possesses a characteristic (3R,5R) stereochemistry essential for reaction with penicillin-binding proteins and beta-lactamases. Two genes (oppA1 and oppA2) in the clavulanic acid gene cluster encode oligopeptide-binding proteins that are required for CA biosynthesis. OppA1/2 is involved in the binding and transport of peptides across the cell membrane of Streptomyces clavuligerus. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.22716e-119
NZ_CP017717.1\|WP_080047640.1\|12958419_12959832_+\|hypothetical-protein	gnl\|CDD\|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	7.63578e-17
NZ_CP017717.1\|WP_080046329.1\|12967002_12968235_-\|beta-ketoacyl-ACP-synthase-II	gnl\|CDD\|274452	TIGR03150, fabF, beta-ketoacyl-acyl-carrier-protein synthase II. 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NZ_CP017717.1\|WP_080046324.1\|12961311_12963834_-\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	6.24354e-26
NZ_CP017717.1\|WP_080046316.1\|12946258_12948349_+\|RecQ-family-ATP-dependent-DNA-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	2.37301e-140
NZ_CP017717.1\|WP_080046313.1\|12939064_12942169_-\|glycosyl-hydrolase	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	7.08496e-83
NZ_CP017717.1\|WP_080046328.1\|12966128_12966623_+\|DUF3145-domain-containing-protein	gnl\|CDD\|378644	pfam11343, DUF3145, Protein of unknown function (DUF3145). This family of proteins with unknown function appear to be restricted to Actinobacteria.	6.16728e-89
NZ_CP017717.1\|WP_080046322.1\|12957409_12958252_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	1.84906e-89
NZ_CP017717.1\|WP_080046314.1\|12942431_12944936_-\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP017717.1\|WP_080046327.1\|12964939_12965953_-\|S8/S53-family-peptidase	gnl\|CDD\|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.01033e-34
NZ_CP017717.1\|WP_080046319.1\|12952259_12954938_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	9.90357e-135
NZ_CP017717.1\|WP_080046312.1\|12938595_12938970_+\|glyoxalase	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	1.80319e-26
NZ_CP017717.1\|WP_080046311.1\|12937994_12938561_-\|thioredoxin-family-protein	gnl\|CDD\|239267	cd02969, PRX_like1, Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic cysteine found in PRXs, which aligns to the second cysteine in the CXXC motif of TRX. In addition, these proteins do not contain the other two conserved residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF.	9.54448e-83
NZ_CP017717.1\|WP_080046323.1\|12959918_12961304_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|366708	pfam01565, FAD_binding_4, FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.	6.38801e-23

>NZ_CP017717.1|WP_080046320.1|12955095_12955686_+|phosphodiesterase
MRETRVSAAGLREAIERSGYYPDLVTDAVESALGKEAVTAFVVHHEATFDPAMEVRRHVTVLVLSATRLLVCHTDEHPAVEGVSASHASTTTEAVRLSRVQSVAVTRVVPDPASYVPGVPPTEVTLTIGWGAISHVDLEPATCGDENCEADHGYTGAITADDLSLRVSEAADGPEAVTHVLAFAKALSEATARATS
>NZ_CP017717.1|WP_080046319.1|12952259_12954938_+|GNAT-family-N-acetyltransferase
MGCGFTVETVEAQYPAHWEADVVLADGGTAHVRPIRPADADRLRSFYSRLSDESIYFRFFGPRPRLSDREVERFTNVDYVNRVALIATIGAEMVAVIRYDRTGPGEAEVAFLVEDAHQGRGVASVLLEHLAATARERGIERFVADVLPANMRMTGLLRQAGYTAQSQFEDGVVRMTLDLTPTDTSTEVTIAREHRAESRSIARLLTPGSVAVIGASREPGGVGQTVLRNLLAADFTGPVYPVHREVRAVAGVRAYPSVGEIDGDVDLAVVAVPAEGVLDVVKECAEKGVHGLVVVSSGFGETGEEGRARQDELARIARSYGLRVVGPNCLGIANTDPAVKLNATLAATVPGRGKVGFFSQSGALGTALLQRVAQRGMGISSFVSAGNRADVSGNDLLQYWEEDDSTEVILLYLESLGNPRKFTRLARRIARSKPVVVVKSGGTPSGHSAEELGLPDSAISSLFEQAGLIRVDDLIQLFDVGQLLAYQPLPAGPRVALVTNSDALGLLAAHACRAVGLEPRAPVNLGPAAGAAEYGPALAGELASPDVDAAVVIYMPPIPGRTEEVAGELLRVSKDSGKPVLATFRGHLGMHPALRVPGPSAPSRGSIPSYAAPEEAVRALAHVVRYATWRAQPATPPHELDDIDTVRARELVRAALPDAEATPGGFAQAGPPVEIDAAELLSCYGLTVWPAEVVRSADEAVAAAGRLGWPVVVKVADPGASRRAGTVRLGLTGPEVVRHAYTEFAEQFGEGVELAVQRMAPQPAVPTVVGVIEDPAFGPVVSFGLGEVTARLLQDQGFRLAPLTRDDASALVRSVRAAPLLFGEYGYPPVAVDALEELLVRVGRLAHDLPEVARLDLDQVLVGESDAMILGARAILRTPAGPRLDVGPRRLS
>NZ_CP017717.1|WP_080046318.1|12951209_12952103_-|sugar-kinase
MTRVVVVGDLMTDAVARARYALARASDTPAIVTMHGGGSGANISSWLAVEGAEVAFIGRRGADITGRNRDMELMGYGVDARLVMDPERPTGTCVVLVTHKGERTMLSDPGANAALSPEDLPRDLFAQGAHLHLSGYTLINEGSRDAGLAALDMARRAGMSISVDCASSAPLERTGAEPFLEWTNGAKLLFANTDQAKVLTGRDDPEAAAKVLTAWFPQVVIKMNAEGALWFSNGRPDPVHVAADPVDKIVDGTGAGDAFCAGFLPAWLEGKPPAEALASGCRLAAKAIMHLGARPPF
>NZ_CP017717.1|WP_080046317.1|12948365_12951164_-|protein-kinase
MRSPMAGVRPLRSGDPTSLGSYVLSGFLGEGGQGSVYLGQSPSGEQVAVKLLHTRYAEDERAVRRFLREADSARRVAEFCTARVLDVGEADGRPYIVGEYVDGPSLQRQVSTEGPLRGAALVRLAVATATALAAIHKAGVIHRDFKPGNVLLGPDGPRVIDFGIARALDVSQSVSTSVVGTPAYMAPEQFLGEAQPASDVFAWAGTIVFAATGRGPFGFGALPVVMHRIMNGEPDLSGVPESLVPLLRASLSKDPHQRPTADRLLQELIRGSAPMTAPPPPVPQPSVPQPSVPQPSVPRPGDGASGPGAGWVSPGHSHPPGAGSSGAGLGTGPGAGAVTTARKGGRRLLVSVSAAATALVVGVAAWAVVRLSDGGGRTPTTNLADSPAPSRAPGGYGSGLTSVVRPSARKGGTVRVSSQNLLESTDPADMFTMYSRNMVRLYGRSLTMFKPAPGPAGAEIVPDLARSLGRSSDGGRTWTYKLRQGVRYQDGTAITSKDVKYAVLRSMDPGFAQGGLFFDTLLDLPAGYEGPYKSPGADTDRAIETPDDETIVFHLRKPLATFDQVVQLPETIPVPKARDTRADYKSAVVSSGPYQIESTREDYVALVRNPHWDPASDPNRTALPDRFVFTYGMKGDEVSTLLKAGETEMGGFLPDEEYAPILADPALKARADAPVTAVRTLAINPQVPPLDKVDCRRAVVRALELEAVSKASRAVPDQVPTSLVPPDVAGVRYADPALSPRGDKEGAREALERCGRPDGFTTKYIYRELPGEKEAAETVRDSLAKVGIHVTLDHAPVEKFHKEFGGVPANLKRDGVGLIARSWAPDWPDPSTYLPALVDSRELSEKEPSVNLTVRLPDVDELIDRATAEPDPTIRSGLWERVERRVAEEAVLVPTTWRRTLLLRGATATNLHVSPVFGDYDLVTMGVDAARS
>NZ_CP017717.1|WP_080046316.1|12946258_12948349_+|RecQ-family-ATP-dependent-DNA-helicase
MLREEAEERLRALAGEHAVLRDDQWAAIEALVVGRRRVLVVQRTGWGKSAVYFVATALLRELGEGPTVIVSPLLALMRNQIAAAERAGIRAVTINSANPEAWEEIYGQVAEGLVDVLLVSPERLNNPDFRDNVLPELAESAGLVVVDEAHCISDWGHDFRPDYRRLSTLFADLPPGIPVLATTATANARVTRDVAEQLRLPPELRTEGDDTLVLRGPLERESLHLSVVRLPSAEQRLAWLAQTLRELPGSGIVYTLTVAAAHEIAGYLREQGLEVAAYSGQTEPAERLAAEEALLNNKIKALVATSALGMGFDKPDLGFVVHVGAPQSPVAYYQQVGRAGRGVERAEVILLPGTEDRDIWAYFASLAFPPETVVRTTLQTLEERGVMSTPALETAVDLSRSRLEMMLKVLDVDGAVRRVKGGWEATGEPWAYDTERYQRIAAERRAEQEAMLAYLTTTECREQFLRRHLDDDTATPCGRCDNCTGRHRSPEIGAQAVESARERLSRPGVEIEARKQWPTGMPDLSGRIKPELGAEPGRALGRLTDIGWGNRLRELFAGPDGPVPDDVFAAVIKVLAAWDWRERPVAVVNVPSASRPALVRGFAERLAQVGRLTYLGELGYRAGTPGKQFNSAKRVQAIRGTLAMPKELGAAIAQCGGPVLLVDDRVDTGWTMTLAAAQVRHAGAPAVLPLALAVTS
>NZ_CP017717.1|WP_080046315.1|12945338_12946160_+|taurine-dioxygenase
MIEFHPVTKHIGAEVTGVDLRKPLSEEEVATLRAGWLEHLVLFFRDQHIDDEQHLQFALNFGTLNHPAFKKDSTSPIHVLDQTSPKGEGGDEWHSDNTFEPTPPMGSLLRCVQLPSVGGDTCWANTYLAYETLSKPIQRLCDELTAEHDITMSMKKAISKGHPFDLAEIQAKWPPVTRPVVRVHAETGRKALFVNRASTTRLVELSDRENEALLPYLIDHIRSPEFQLRLRWRPGTLAFWDNRPTQHYAVADYTERRRMHRVTINAFPEHADK
>NZ_CP017717.1|WP_080046314.1|12942431_12944936_-|DNA-topoisomerase-IV-subunit-A
MARRTTAPPPEDFEERIVDIDVSAEMRASYLEYAYSVIYQRALPDARDGLKPVQRRILYSMSEMGLRPDRGHVKSSRVVGDVMGKLHPHGDSAIYDALVRLAQPFSMRLPLVDGHGNFGSPDDLPAAMRYTEARLAPAAMLMVESLDEDTVDFKPNYDGQETEPTVMPSAFPNLLVNGTSGIAVGMATNMAPHNLVEVVSAARHLIKKPDATLDELMKFVPGPDLPTGGSIIGLQGVRDAYETGRGTFRMRAKCAVEQITPRRKGIIVTELPYNVGPERVVTKIKELVTSKKLQGIADLKDLTDRHKGLRLVIEIKNGFIPEAVLEELYRLTPMEETFGINNVALVDGEPRTLGLREMLQVYVDHRLEVVRRRSEFRRRKREERLHLVDGLIIALLNIDEVIQVIRSSDDSAQARTRLMEVFDLTDIQAAYILDTPLRRLTRYDKLELDREKETLSDEIAKLTEILSSETKLRQVVSGELADVAKKYGTPRRTVLLEAPGITRTPVVDLQVADDPCLAMLSSTGLLARTPDASPLPGEGDRTAHDVLLSVVRTSVRGEVGVVTSLGRLIRVQVVDLPTLPPSNNPPSLSGGHPVSEYVSLQPDEKVVGLGSLDPDGPGLALGTAQGVVKRVVPDYPANRDDFEVITLKDGDTVVGAVELESESHDLVFISSDAQLLRYSASLVRPQGRPAGGMAGIRLDDGARVIWFGAVDPERPAQVVTVAGSSTALPGTQVGGGKVSDYAEFPAKGRATGGVRAQRFLKGEDELLLAWAGPAPAKAVSAVGKPVPLPEEIGRRDGSGVRLTHTIGAIGGALGSGPAPQRGDDARSSEDSGDE
>NZ_CP017717.1|WP_080046313.1|12939064_12942169_-|glycosyl-hydrolase
MALRRSLLRERSPPGGTVFRSRRALWAAALALLTPLLTTQPAPAAAAPLTITDFESDGVPAGVSAWGNDAASTPALTIEPGADRPEAPATNRVLRSVYAISQWGGWSHDLTATQDWSPYEGFSFWVKGTASGQKIFFEIKDGGGSAGASELFESSFTDDAAGWRQVKVPFADFTRRTDYQPGGAPTDGELDLVAMWGYSMRLPAAQGTLLWDQVELYGTAPPRPVRLSTARPVYPVDEKGQAEIGVTITTSDGAPLPADLAVDYRTGTGTATPGADYTAVQGMLTFPAGTASGATQRITVRTLRDGQDEVAETIPVELSGAGTRPPAEPPVVVINAHGLPYLNARKPVKERVADLLGRMTLAEKVGQMTQAERGALAKQSDIAGYLLGSLLSGGGSTPARNTPEAWADMIDGFQLQTRRTRLQVPLIYGVDAVHGHNNVVGATIFPHNVGLGAARDPELVERAGRVTADEVRATGIPWDFAPCLCVSRDDRWGRAYESFGEDPALVSRMATVIDGLQDHGVLATAKHYVGDGGTAYGSSTSGDYTIDQGVTRVSRDELERVHLAPFKEAVRRGVATVMPSFSSVDFGEGPLKMHAHDELINGTLKGRLGFKGFVISDWQAIDQIPGDYPSDVRTSVNAGLDMIMVPYAYPQFTGTLKAEVEAGRVPMARIDDAVARILTQKFRLGLFERPYADRSGIDRVGSAAHRAVARAAAAKSQVLLKNDGGLLPLRRDAKVYVAGSNADDIGNQSGGWTITWQGSSGPITPGTTILDAIRSRAASVTYSRDASAGLAGHDVGVVVVGETPYAEGQGDVGRAGRTLELSAADRAAVDRVCGAMKCVVLVVSGRPMLLGDLSGVAAVVASWLPGTEGDGVADPLFGAVPYTGRLPFTWFRSMEQVPINVGDASYDPLFPYGWGLRTDRARDRLKAARDELARGDAPARAAAATLTLALSGRNWDAGGSVRDARAVLGALGAAAALLERSKSDSYAVDDAVVSVARDVAQRAGKRFGLQAAADHELASGDLTRAVDLLAQAAR
>NZ_CP017717.1|WP_080046312.1|12938595_12938970_+|glyoxalase
MGGIAEFRTVVLDCPDPRGLAEFYSRLLGWPVTSVEDDWVVVSDGGPPKRLAFQLAPDHRPPVWPSAERPQQFHLDVTVTDLDEAEREVLKIGATKHEHQPSEDDEFRVFLDPAGHPFCLCRDV
>NZ_CP017717.1|WP_080046311.1|12937994_12938561_-|thioredoxin-family-protein
MAANSFMVPLGTPAPAFDLTAIDGGSVSLEDLKGSPASLVVFLSNHCPYVRHIESGLGALAKDYGARLSIVAICSNDSVNYPDDDPTHLAEQAARAGFTFPYLLDDTQEVAKAYRAACTPDFFLYDEQFRLVYRGEFDGSRPGNGVPVTGSSLRPAIDALLDGGQVPERQNPSLGCGIKWKPGNEPVA
>NZ_CP017717.1|WP_080046321.1|12956297_12957413_+|alkaline-phosphatase-family-protein
MLLPGYGGASLAEVPRSLLAALGLREPNALALEQADRVCLFLVDGLGAELLRAHPEAAPFLTSGMTARTLTAGFPATTVTSLCTLGTGLTPGEHGMVGLMLAVPGTGHLLNCLRWTHPDGMTVDPDEWQPATTVYQRAAAAGVEPVYVGPAQFEGTGLTRAVYRGVRYVPADSVDDRVARVHEALRERRPAYVTVYYGDLDAAGHMTGWGSEEWLRQLALVDDMARRLAEGLPPGSALYVTADHGMVNATEKIDAESVPELTDGVALLGGEARARHVYARPGAAGQVLDAWRETLRGKAWVVSRQEAVESGWFGPHVRDAWLSRIGDVVAVPHTDLAITAPTRHRIEALFTGYHGSLTAAEQHVPLLEVRP
>NZ_CP017717.1|WP_080046322.1|12957409_12958252_+|sulfurtransferase
MTSPLITATDLAALTEPAGAVTVLDVRWRLGGPPGLDFYREGHIEGAVYCDLDTDLAAPTSAGGRGGRHPLPDAAAFESAMRRLGVSGGRPVVVYDDAGATVAARAWWALRYFGHQDVRVLDGGLQAWIEAGLPVTKDVPQPVPGDFTARPGGMPALTADEAATLAGQGILLDARAAERYRGEVEPIDPVAGHVPGAVSAPTTANLGPDGRFLAPSELRARFGGLGVREGEAVGAYCGSGVTAAHEVLALEVAGLPASLYVGSWSDWVSDPSRPVATGDR
>NZ_CP017717.1|WP_080047640.1|12958419_12959832_+|hypothetical-protein
MTVTLFFGLSLAELSALAAAVVLVLARWLPPGARRPSTWAGAVVLVVSAIVLAVLGLRWQLVPVLVGGAIALAFAVPILLRRPVRRARWWLALPGSAACLALVLAGAVAAWALPLPVFPEPSGAHATGTTVVQWTDPDRAETATSRTDDKRTVVVQLWYPAQGDPAARRAWYLGRTEREARLVARGQAGYLGLPGFILDEAARARSRSVPDIPAAAGRFPVVLFSPGLGGVRTQNTAWAEELASRGYVVAAIDHPYDSAVVTLDDGRAIRTRVTATGDDAEDNRRAAGWTAVRAADLSFVLTQLDRLDRGEIKGPLTGRLDIDRAAATGHSLGGAAALQAARQDPRFAAVIDIDGYPRDPAPRPFDQPVLALTHDVRQGEEQDYISRLTQVLQLSTATGYRLTVPGSAHLTFTDAPLFLPPLPTLVGSLGRTAGPHITAATTAAFLDATLRGEPGDLATTLSKYGRLTVL
>NZ_CP017717.1|WP_080046323.1|12959918_12961304_+|FAD-dependent-oxidoreductase
MSEKTLLTSVHGRTLYPGDPGFEEACSGWLLTVEHRPAVIVVAADAADVVTAVRFAARTGRPIAVQSTGHGKSVPADGAVFIATNELRELRVDAAARTARIGAGLRWGEVLAGTAEHGLVPLCGSSGEVGVMGFLTGGGLPLAARTYGFAADHVRSLDLVTADGRLRTVSPAQEPDLFWAVRGGKSNFGVVVAAEIELLPLRTIYGGTLTYGAEDPARAAHVLRSYLAWTKDQPDEMSSSVTLMRLPDVPQLPEEFRGRSLMQIRVVLMGDDASAVEPLRALEPERDTCAAMPYTEITGIYQDPKNPVSAHLRSALLHELDDEAVAELVSLIDPSAPGGSSPGIELRQLGGALNRAPRRPHAVSTQGAAFHLWLRVPAPPGQAVAARETADEVLERLRPWDTGAMLPGFLFDPDAAPDRVRRAYTEADHRRLAALKAVHDPDDLFRINHHIPPLGDDEAAK
>NZ_CP017717.1|WP_080046324.1|12961311_12963834_-|CHAT-domain-containing-protein
MSAKPHAPDSPDDLDPLVRAAEAALMRALVDPDQALRAGRVIIESARRHRCPEAEAMGLRTMALAARELGDLEKAEQYLREALAVRDAPPHRIAQARLSLVSVRTERGHPLQALRLAALAWAYLGPLDRAKLDTQRAVALARLGRYQEAIASCDRALMALVTAPGTIDDRRFLAGGLLNRGLVHAYRGDWDASMRDLTACLQISQFAGLWHLARLAAANLPFLAVRRGDIAGAFRHYREAEETLFGYPERLASMRADFAGALLAAHLPGEAGTMLRMAVPDLEAAAALTALADARLKLAQVELLTGDAHRARQVAEQAAAELAAQDRVSWLPLAKEVVLRSRLVLEPVTPELVAELITCADELEDAFAHRAGAALRLAAAEAALSVDDHPTASAQLARLTRHAERRDRWVPAGTRLTSLASEPQARQLAQASEIPVPVRQHALALQAALQEDVAGAFRAVRDGLAEVSGRVEAFEDPSLRAHAARAGERLAAYGLELAVRDGCPREVFEWAERWRAVAAPAHACALVDPERVRAELGRAALVEYVADGDALLAVLLSEDRLVLRRLGPLRPVMDTIVRLRHALRRNSGRADVEEAATELERLVLRPFAAELADRPLVVVPVGALHTVPWGALPSLRERPVSVAAGAAAWMRARTARTARCGGPPRVVAAAGPSLRHAQSEVEHVLACHPGGRQVAGRVGPVLEALGTADIVHLAAHGAFHARSPLVSGITLEDGQLMAYDLLDVSRSAALVVLSACNAGMSRAPVEGAPLGLPGTFLAKGSACVVAGMVPVEDETARAVMSTFHELLAAGRSPDVALAMAAAKADETGFVCFGAGDQPFC
>NZ_CP017717.1|WP_080046325.1|12963899_12964343_-|carboxypeptidase-regulatory-like-domain-containing-protein
MINDEYFLAALRLEAGTDPIPLRVSSSSRDVWRLRLPHAVTATQEATTIRSVRADDSSHLVRFVATGLTFDLEVTEGDGLIDVAGHISPYPGEGALVDVRSPHLTLTRRITPNGHFAVTGLPPGWLSVVCHRPGHLPVQTTWVRIRP
>NZ_CP017717.1|WP_080046326.1|12964339_12964867_-|sigma-70-family-RNA-polymerase-sigma-factor
MRDSAELLTAAADGDRSAWDELESRFGPRMWAVARACGLSPADAADAVQGTWLRLLQHLRNIRDPGAVGGWLVTTVRREAFLLLRKDLPVVSSSEAVTEVDPAAVVLEADDRQLLWKTVSTLNEPCRSLLQLVALDLGNRQVASRLGMPAGSVGPTKARCLEKLRTLISLQETAQ
>NZ_CP017717.1|WP_080046327.1|12964939_12965953_-|S8/S53-family-peptidase
MEIQSVGEAFIRPGQLLTDRTALAAVSRWTQAVSEADGVCVVHLSSGVDPCELTAELRGQGLRASPNHVLRGQPLFFGGPASRPFPTPPIPYKAGRSRSHVVVGLLDTGVTKHPWWAGSDWYAGVGPEEADAYEGAQAGHGTFIAGLLTRRAPGVRLRVGRVLDGDGLTDEATVVRALYRMRERPPQVLNLSFGCHTFDDRPPPLLSDAIGALSATVTVACAGNTGSDRPFWPAALPCVVGVAAVDATQQRRAPYSGHGTWVDACARGDWLTSSYLDAGEYGGYAAWSGTSFATALVAGAIADAARHEPAKEWIRNLLDSEETPQIPDLGVLFPTSL
>NZ_CP017717.1|WP_080046328.1|12966128_12966623_+|DUF3145-domain-containing-protein
MSARGVLYVHSAQPALCPHIEWAVAGVLGVPVDLTWTPQPAAPNVVRAQAEWEGRPGIAAAIASSLMGWQRLRFEITEDASPGVDGSRHAYTPTLGAFTAVIGAAGDIMIPEDRLRAAMMMAAQGRCVLEEELDKMLGKPWDEELEPFRYAGDGAPVRWLHAAV
>NZ_CP017717.1|WP_080046329.1|12967002_12968235_-|beta-ketoacyl-ACP-synthase-II
MSANRVRVVVTGLGATTPVGGDVTSTWTALLAGQSGVETLTTDWIDAVPVKFAGTAAVDPTEVLPRPEARRLDRSEQFALVAAREAWQDAGAPDVAPERLGVVVSSGIGGISTTLSAYDTWKERGWNRLSPFTVPMLMPNGPAAWIGLDLGAQAGVHATVSACASGAEAIGSAMDMIRAGRADVVVAGGTEAAIHGLNMAAFAAARAMSQRNDDPQGASRPWDRDRDGFVLGEGAGIVVLESEEHAKTRGARIYAYCAGVGYSADAHHITQPEPEGRGIIMAMTQALTDAGITGLDVKHVNAHATSTPAGDVGEVQAVAKAIGTHPLVTSTKSMTGHLLGGAGGIESVFTIKALQERIVPRTINLDNIDDGIEVDLVHGENRTLPAGDIAAVNNSFGFGGHNVTVVFTGA

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Crispr_ID: NZ_CP017717_44

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017717_44

13028253-13028329

Orphan

Consensus_repeat	Method
CCGCCGTCGCGCCCGGGCGGTGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017717_44

>merge|NZ_CP017717|44|13028253-13028329|CRISPRCasFinder
CCGCCGTCGCGCCCGGGCGGTGGGGGTCCGGAGGCGACGTCGGCGGGATGGCCGCCGTCGCGCCCGGGCAGTGGGGG

>NZ_CP017717|44|37|13028253-13028329|CRISPRCasFinder
CCGCCGTCGCGCCCGGGCGGTGGGGG	TCCGGAGGCGACGTCGGCGGGATGG
CCGCCGTCGCGCCCGGGCAGTGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017717.1\|WP_080046386.1\|13033198_13033618_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036175.1\|13033614_13035132_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226017
NZ_CP017717.1\|WP_080046379.1\|13021003_13023007_+\|Xaa-Pro-dipeptidyl-peptidase	unknown	unknown	gnl\|CDD\|235435
NZ_CP017717.1\|WP_155130198.1\|13035162_13035996_-\|DUF4253-domain-containing-protein	unknown	unknown	gnl\|CDD\|379446
NZ_CP017717.1\|WP_155129437.1\|13029212_13030556_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|237361
NZ_CP017717.1\|WP_080046380.1\|13023454_13025284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224511
NZ_CP017717.1\|WP_080036174.1\|13031600_13033187_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|273327
NZ_CP017717.1\|WP_080036178.1\|13036692_13037337_-\|TenA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|381693
NZ_CP017717.1\|WP_155129431.1\|13014465_13019157_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046377.1\|13019236_13019896_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP017717.1\|WP_080046389.1\|13030800_13031595_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|252734
NZ_CP017717.1\|WP_155126247.1\|13027309_13027522_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080046381.1\|13025329_13026493_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|366675
NZ_CP017717.1\|WP_080046378.1\|13019958_13021005_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP017717.1\|WP_080046382.1\|13026489_13027233_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226004
NZ_CP017717.1\|WP_155129434.1\|13027530_13028103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036179.1\|13037447_13038605_-\|TIGR03118-family-protein	unknown	unknown	gnl\|CDD\|132162
NZ_CP017717.1\|WP_155129428.1\|13013673_13014306_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017717.1\|WP_080036177.1\|13036091_13036670_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319790
NZ_CP017717.1\|WP_080046384.1\|13028339_13029074_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP017717.1\|WP_080036175.1\|13033614_13035132_-\|hypothetical-protein	gnl\|CDD\|226017	COG3486, IucD, Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	0.000914575
NZ_CP017717.1\|WP_080046379.1\|13021003_13023007_+\|Xaa-Pro-dipeptidyl-peptidase	gnl\|CDD\|235435	PRK05371, PRK05371, x-prolyl-dipeptidyl aminopeptidase; Provisional.	0
NZ_CP017717.1\|WP_155130198.1\|13035162_13035996_-\|DUF4253-domain-containing-protein	gnl\|CDD\|379446	pfam14062, DUF4253, Domain of unknown function (DUF4253). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 110 amino acids in length.	1.36335e-45
NZ_CP017717.1\|WP_080046380.1\|13023454_13025284_-\|hypothetical-protein	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	6.06934e-06
NZ_CP017717.1\|WP_080036174.1\|13031600_13033187_-\|MFS-transporter	gnl\|CDD\|273327	TIGR00895, transport_protein, benzoate transport. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	6.04503e-32
NZ_CP017717.1\|WP_080036178.1\|13036692_13037337_-\|TenA-family-transcriptional-regulator	gnl\|CDD\|381693	cd19358, TenA_E_Spr0628-like, TenA_E proteins similar to Streptococcus pneumoniae Spr0628 and Saccharomyces cerevisiae S288C PET18. This family of TenA proteins belongs to the TenA_E class, and lacks the conserved active site Cys residue of the TenA_C class; most have a pair of structurally conserved Glu residues in the active site. TenA_C proteins (EC 3.5.99.2; aminopyrimidine aminohydrolase, also known as thiaminase II) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway; the role of TenA_E proteins is less clear. Arabidopsis thaliana TenA_E (not belonging to this family) hydrolyzes amino-HMP to AMP, and the N-formyl derivative of amino-HMP to amino-HMP. Members of this family include the putative thiaminase Streptococcus pneumoniae Spr0628, and Saccharomyces cerevisiae S288C PET18, a protein of unknown function whose expression is induced in the absence of thiamin. It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect. Many proteins in this family have yet to be characterized.	3.52383e-84
NZ_CP017717.1\|WP_155129437.1\|13029212_13030556_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|237361	PRK13355, PRK13355, bifunctional HTH-domain containing protein/aminotransferase; Provisional.	8.75265e-10
NZ_CP017717.1\|WP_080046377.1\|13019236_13019896_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.01854e-41
NZ_CP017717.1\|WP_080046389.1\|13030800_13031595_+\|hypothetical-protein	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	2.16287e-51
NZ_CP017717.1\|WP_080046381.1\|13025329_13026493_-\|FAD-binding-protein	gnl\|CDD\|366675	pfam01494, FAD_binding_3, FAD binding domain. This domain is involved in FAD binding in a number of enzymes.	1.72778e-45
NZ_CP017717.1\|WP_080046382.1\|13026489_13027233_-\|hypothetical-protein	gnl\|CDD\|226004	COG3473, COG3473, Maleate cis-trans isomerase [Secondary metabolites biosynthesis, transport, and catabolism].	8.59856e-12
NZ_CP017717.1\|WP_080036179.1\|13037447_13038605_-\|TIGR03118-family-protein	gnl\|CDD\|132162	TIGR03118, PEPCTERM_chp_1, TIGR03118 family protein. This model describes and uncharacterized conserved hypothetical protein. Members are found with the C-terminal putative exosortase interaction domain, PEP-CTERM, in Nitrosospira multiformis, Rhodoferax ferrireducens, Solibacter usitatus Ellin6076, and Acidobacteria bacterium Ellin345. It is found without the PEP-CTERM domain in several other species, including Burkholderia ambifaria, Gloeobacter violaceus PCC 7421, and three copies in the Acanthamoeba polyphaga mimivirus. [Hypothetical proteins, Conserved].	5.7995e-67
NZ_CP017717.1\|WP_080036177.1\|13036091_13036670_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.57254e-28
NZ_CP017717.1\|WP_080046378.1\|13019958_13021005_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.37453e-56

>NZ_CP017717.1|WP_155129434.1|13027530_13028103_-|hypothetical-protein
MPDLVGAVLTASAVAAGVLAVSRGGAWGRLSSRPRGRPRTPAALPLNSRRRRARDPRRDGGPTRAATMAAAPPAMPVVRRVGLGRVVYGGVPGLDGTIGTAAMPGGTIAVTGATMPIDRPPPRGPSPGHARVLMAVPPATVLLAATALVRVAVASERETGPPPRRAAGEEPVATPRRLLSAPHPSPPAST
>NZ_CP017717.1|WP_155126247.1|13027309_13027522_-|hypothetical-protein
MLTDELRRSQPHEVHPRGVRPGAPPPPSGGKPREEDQGAARTVHQLRRIRQVSVAAITEIDHALTHHRTP
>NZ_CP017717.1|WP_080046382.1|13026489_13027233_-|hypothetical-protein
MSRRRIGVLVAPANPSAEPELTRLLGSRADMHVARLPARPGRSLIDRLESYNSAVPAMLGAFDGLRLDALVMACSEPRYLLGPDEDREQCAELTAATGVPFASATQATREALEHVMVTDIVLVSPYQPWVTDLAERFWKTAGLNVTQVVQVRAPDGYSPYGHTPASLVSQVELAEVPGDAVLLFTGTGLPTLPVLRPLTSGNDRTLLTSNLCVAWWALSKAVGRHVTLSRVPYRRHMAAAARVGGRP
>NZ_CP017717.1|WP_080046381.1|13025329_13026493_-|FAD-binding-protein
MNGVIVAGAGPAGLTAALCLARAGIPVTVLERESELPRQARACTFHPATLDLLDDLGVASRLVAAGRVVERVQWRDRSGIVLAEMGMNRLDGLTKHPFRIHADQARLTPLLLSALSVYPDVDVRFGTHVDGVAEGGTGIRVRVGHTWTRARYLIAADGAHSTVRGSLGLPFPRSACPAQALRVFTDAPLDRLLPSLAPLTYVRDVQQSCTLLGLPDHWRIIFKIPCDTHEPLSAPNLSLLVRRALPGAGEPIRITGADRFGLSRGVLTSYRCGRVLFVGDAAHLTSTVGGLNMNAGIHDAAEAGQVLAAVLHGSARPAALEAWAWRRRSVLLHRVIPRGETRPAGVRERDSARLAAAMAGLRAIAGDPDATRAYLAQASLLDTPGGT
>NZ_CP017717.1|WP_080046380.1|13023454_13025284_-|hypothetical-protein
MWRTLSDDARQAIRDLCDKHGARLYDYCRTELAAGDAEQAVAGAAMTVHLYADRVVDPALRRPWLYAVARAHRAVVAKPASIGSWSRPGRMSELLPEALLSLERPQRELLDLSVRHGLADAELAAIFELPEPEVHAIVARAAAGLEEWFAAIIAARSRAGCPVLTARMAEWVAAPGRRARARIGRHIQSCATCRAAPRTMTAGALLRRLPIATLPGTLPNRLASAQPLPGEGPLWRADGFPVQARTLVETGLSSPAPPVADTTPPAQVAGPTTATSGKPWSAAGAAAADQEPPGRPIPLSAPIPGPDPDPEQAGAGLGPPGAPAVRGRHPFTPPSRTRPFRGGAYGDKLVYTTAIKGESNGTHQSGAIVRYGGLTLSALEQPANGDAAQWQEYWRLPADEDDDPEPGTPIRAVARLALILGVGLLAAGLIWAVLNAQSQPATITKTAAQTTLLLNAPADPTVSATTQTLAGSGLRSVPKKTALPRPAPPVARLSPPSLSLGSGRSGTFSLSCTGRCAITSTSATAGITVSGHRFRIQAPRDACELGAVERHGRITVRWTGHTTGDGRTTGGITRAGGSLTLRISWTSPRSADSGTTLSVRNGDPHRPCD
>NZ_CP017717.1|WP_080046379.1|13021003_13023007_+|Xaa-Pro-dipeptidyl-peptidase
MPWILPPSWLFERLRLFRPIVSRRSRVSQLRPALFAVALTLAIATPAQAAAAAPAITVRDGRTQPVFSYADAVREHVYVESPVDSDADGALDRVRVDIIRPKESGPGLRVPVIIDESPYYDNSGRGNESERKVYDAAGNVTKFPLFYDNYFVPRGYAVLNVDMLGTTRSDGCPDVGGKADVLGGKAVIDWLNGRAKAYRADGTPAVADWTTGRSAMIGKSYDGTLANAVAATGVEGLKTIVPISAISSWYKYQRSNGVIYNLDYASFLANYVDTDPDAKCQAVRDRMDAEDGDDTGNYNRFWAERDYINGLLADVSKVRASVFVVHTVNDLNVKPDNFSAWWKALADRNVPRKIWVGQTQHVDPFDFQGRRDLWVDTLHRWFDHWLHGVRNGIMNEPRADVEIGPVQWITQRDWPAPYAINASLRPAPDGTLGLRPAAGNSTATFTDVAMSENDMVAGIGTPNPGRVAFTTGALPLDLRLSGTPTADLRVKLDRPTANLTALLVDLGDATRVDWRRGQGITTLTEEDCHGESTAADDACYRKVVTNLATRPLEIVARGWIDVQNRQSLSRPTPLPAGSYGTVRWLTLPQDYTFKKGHRIALVVAGTDTTYTDEAGTGAAVTLDLSRSSVNVPLVLGTPLADVPQDAATFRGPAEVELPEPETGFHFF
>NZ_CP017717.1|WP_080046378.1|13019958_13021005_-|ADP-ribosylglycohydrolase-family-protein
MEVLDRVRGCLLGGAVGDALGAPIEFQSLRDIRKHHGTDGITGYVATWRGRTGLITDDTQMTLFTVEGLLDARATAAHATETQGQDGGDAREAAVEAVRRAYLRWLDTQQHPAPPPATLPHHTGTLREEGWLYSRRAPGNACLSGLHRPFPGPSAWGVPGPVNPDSKGCGTVMRSAPFGLVNRLPQEAFELAAACAQITHGHPTGYLAAGAFAAIIAHLMAGQALEPAVHETMELLARYPGHEETTAALRAAVHLASAGGHSPEAVESLGGAWVAEEALAIGVYCALAEPAVDRALLLSVNHSGDSDSTGSVCGNLLGALHGTAPLPAAWLSPLEGRPTIERLAAALV
>NZ_CP017717.1|WP_080046377.1|13019236_13019896_-|FadR-family-transcriptional-regulator
MRNVARTSLVDAAIAELRREIAAGVWPVGTKIPSESRLAESLGMSRLSVREAVRVLAHAGLLHTRQGDGTYVTATDESQVALRRRLDTAAAMDIIDVRRGLDLVAARLAAGRRTDDDLTAMRDTLARRNAASRAGDLDGFADADVDFHLLVADAAHNALLGDLYRSMSDALRDSVRDQEEAALVPDSSHEELLQAIEERDAAKAVAVSVAILDQQERHL
>NZ_CP017717.1|WP_155129431.1|13014465_13019157_+|hypothetical-protein
MDWPNCPSCGVALTGTVDACPECRLLLHGPAASDYLDVVAALAELDGRRVELLRRREEALAGMRAATDAARIAADAADAVDPASVVAGVPVVAEGVPVAGVGGEGERGPRRDLSHRAVQNVLLLLGGTLLSIAAVVFTLVSWQVPALRALILTVFTVAVLAAPWLLVRRRLVATAETVALLGLVLIPLDGVAVMQVFGDGGGGGAGPEVDSLWGWAVAAAGLSLVWAVYAWWAPLRLPTPVAIVLAQVPLPLAALAGVGSGPLDDVPGLAGALVVDAAFDLVLWRVARRARVAVEYVTTAVAGAVAWVGGVGVAAFAMVVVMAGDGFVPITDPRPVLVTGLSPGVGLVLGGAAVVAVLWAGATRGRGARLVIGAGGALAGVGAGCALTASVVPGVDGAAVAACAASLVLVVALWLPARLRDGVRTGGALVLGVAACLQAQAVIAVALGPLGWLTSAWGERAGRASELLGPDLRWDDAGAAPVVMAAVAVGSALVPAGREGWTPALRRMSCLVSGCLAVVMAPVSAGLGYEVGLGVVVALASALMWRAAAHRPASGGGGAGSSGRGGVGVLWVGGYLGGLAMCWGLADRTASVTVAGVLAVVWAGCAVAGRTKGVQAVGGAGATVAAGMLVWGMFGSGLAAAVAMLGVRAGTLVVTRPSRKLAAAVVRAGRTSTTLALGILDRLTRLVRPGGRTAVEAAAMVVALLALAQYRFGPEHVTAGEGLPLLPGRLGDEMPALLLAVGAVLAAASAWRRPRGAWRTVAAVEACLLAVLAPLPLSGAAVPALVGPYGWLTHAWAGAAEGARAALSPAGPWQAQPLLMPVLVLAGAAGALAVWARWGRQAAMGVAGIAFPVAATALPVVADLPYWAALAFLVALTAALALWSAVSRSAAGGASLWTATLAVSWSLADRTATLAVLAAIAVTALLCAVRGKGSPVTSVAATVTGLAVGAESVAAALGGGLGRSDAALVLLLVIVLLSRAAALPVLPAAVAGPLGAAALALWPVAMLLARDVARLSLVLAAGGLALAASAWRLKGAVRPGAYALAGAASAVAVLPHVPVWAEVLGFPYQGVGRPWRELFGGWVPRPEVWDSGLPMVAGFSFVRAEVATALGAGVFAVATAVIIARRLRGDVAARSVATVAVPVCLVLVPPVAELAYPWVLIFHGVVLVALAVQASAGAGAAGVMALLAGGHVVAWSLDVEAYTLAVLAGITLLGVAASGVARGAAARTGAAASATVAAGGLAAASALSAGLPGEEAAFAVLGVAAVAVLAAARLATLRRAVPGAARAGALGRVVVPAGAQAGAGPHGSVEVVGRAQVVERAEAVGGAQAVESGGAVGRAGGVAVAFGVAEGAEVAGWGVAVAGVVMAGGDRGLLSLALASAGVLALLVALRPDRRAAVWAGLGLLQVALWLRLALSGVVAPEAYTVPLSVAGLVGAWLARRRDPGISSWSGYGLALALTFLPSAYAAWHDPGLARPLLLGVAAFAATLAGARARLQAPLILGGAVLVVTAAHEFAPALAELVGQGPRWVPIAVAGAFLLFTGATYEHRLRDLRKIRRLIVRMR
>NZ_CP017717.1|WP_155129428.1|13013673_13014306_+|hypothetical-protein
MTYLDPVPPRFESGTSYTLGFWVLQHGTHPFEGSMNPVGLRLTRADGKTMEFKGIGLAEAAHYSASVVVPKGVWKVEGIQGPFQPYAVGTLTVPGALRINPLPPGQADMIAQTEQRYWGDVRPPGFKPGTTTPAAEMPAASAAPVVTVTASPPPPAPASDGGVPAYTLLLAAAGGAVATWAVLGLPAARRRRRAEDEPDRTQEDTIVISG
>NZ_CP017717.1|WP_080046384.1|13028339_13029074_-|hypothetical-protein
MTMDSTFLDGPAVPGQEPAVQRICARVAGPGVHVASLPLGGVQVWLDDPGHRWRHYHRMARELRLAGWHTETGPDRLLLLGWSAVCLSHRVRMLGAALTGRLADFDRTAFTAVMVATRLRHEGFPAADLPGEVEAHCAEDLRWPARLADLDGLERCSSLEPLRLRLAQVAGLEAKVGRRCAEHLALASKVARMVAGGAGPARTHAAGEAGPPARARAAGPRAGLTERMVCVSVPNVAESAVTAR
>NZ_CP017717.1|WP_155129437.1|13029212_13030556_+|helix-turn-helix-domain-containing-protein
MAELARMAGDSGASVPYAGPCSRAARRCAVANFAERLDLALTKRGFTGAQVASALTEAGIPITRAYVSQLRTGKQTNPTLQVLRALASCLQVSVGWLVGDDFLESGSVEDLQLRAATIGLSASGLSESSLAVLRGVVELARKAEGLPEEPEPTSDIPEAVAPLSGPQRRALGKRLHGLRLSAQLSVEQVETAIGRGAAAIPAIEEGRIAPPPITVERLLTVYGVSVPPIREYVLSLARGEREAAWYDAQSVPVWLATGYALEGRATVIRTYHNQFVPPLLQTEEYARAAITVAGPATLGQQTVEEALALVLARQEAVPRDNGVVLWAVIDESVLTRSIVGQHVQLRQLEVLIEHAKRPNVSLHVVPMEDPAYVPRTGPFTIWRFAEAFEPDIACAHGIDSDTLITGAAEVEAFHQAFTKLSVTTTTRDETFEMLNFHRERLSRSLGI
>NZ_CP017717.1|WP_080046389.1|13030800_13031595_+|hypothetical-protein
MTQARVTRILDAAAGGKNNFVADRDVISRYDQAAPITTTAARAVLQYLRRVVRHLASEGVDQFVIVGSGVPSGLPPGRQLHDVARNALNGSVPRVVYVENDPMVLAGARATIEPITDLVRVVEGDVREIDEILDDRVLQTFLDWDRPMAVLLLSTHSLNDDEYFHYVIKRIRQVVPERSYLSMMQTTFDAIPAELLPAIHDLLAMTLPGHAIRTREEVEALLDGLVLVDPGLVWVPEWRPDGHDDACAEQPSASGNYGAVARVP
>NZ_CP017717.1|WP_080036174.1|13031600_13033187_-|MFS-transporter
MGGVELARPLYFWLGTLATVAGVLLHLPMYLHGADMHYRLAGMPMDLPMTIGMVLIVAGLVVTAWGLVPPGAFAARPAAEVRVRALDDQRMRPAHIGLIVVMSVAVVIDAMKPITLGFVSPGMVEEYGLRSPLNPGGDLPVALLPLSGLTGTVLGSLLWGWLGDKIGRKPSILYAGVLFIGTAICGVMPSFEGNLAMCLAMGLGAGGMLPIAFSLLAETIPPRHKGWVMVLIGGNLAVAYLLASFLSATLAPEYSWRVLWLVGLPTGVFLILLNRFIPESPRFLLAHGRDAEAHAIMARYGATLTSESDVERVQDEHEGGYSRLFRAPFTGLTTAVVILGLSIGLVTYGFQLWIPSNLRSLGLDQSAADRALADSTLLGLPLIFISAAMYGLWSAKKTIVVLSALVGAALVVLSFSGETLAHDRTWLYVLLAGPIVGTAAIAAVLAAYSSEIYPTRVRSRGSGLSAGVGKFGGVAVTGVLVAGAAAPSIGMTALLGAVPLLLAVVAVLVFGVEPVKGPAGAPAEPAKV
>NZ_CP017717.1|WP_080046386.1|13033198_13033618_-|hypothetical-protein
MIPTLAGRVQTRLFVLATVGVVLTALLALVLPMSLRDAFVMLLAVAVVGVGWELLYHLLMQFRWDKDWPTLFGLVTAVPEGLLMWVLLDAGLVPGVGGPVPFWAFAVMFGVVWIGQWLFVNGPMRVLFVQWRLRGGRLL
>NZ_CP017717.1|WP_080036175.1|13033614_13035132_-|hypothetical-protein
MPWGDLTPELLHSSVWADGLVESAGIPVYDMPLVSVGGGIGSFTLLDVLRIRGVPTSAMRVLSTSDSPWQTWEYLTRVSQLPAHERIRSDSGARPDNIWGFPSYAVQEAWQERSVKPLLQVLTEPIGTDFYSPRAALVMRSVQREADRIGYWEMLAKGQVRMVRKRLGGGYFTVLTPPAGSGPTKRVALRSRYVHLAVGYPGLKFLDDLQEFRQRRGERYRVVNAYEPHEHVYDQLSKRPGVVVVRGAGIVASRVLQRLMDDRERYGLQTTIVHLFRTYVTGSHGPHPFMRRKGGDGWAYQAFTMPKSAFGGQLKAQFRKATPERRARLAALVAGTTTPKLARWQEQLRRARQGSWYHAVQAEVERIDQTPDGRLVTHTRSASSAPMQYVSDFIIDCTGLEADMPEHRVLADLLQHGGARPNKAGRLQVGPSFEVLGTESGDGRLYASGAATAGNHFLAVDSFLGMQTAALDIADDLARRGFCKGLGPVRSVSQWLKWAANRRPA
>NZ_CP017717.1|WP_155130198.1|13035162_13035996_-|DUF4253-domain-containing-protein
MGTVGHERSSAATRAGPLFADGGRGRRLGVALPPGDVVWPDPGYTGQGVPARPAFWMSDEPVTGADWALLREWHPHSGLWPLLLDESAQPWSVGQVVPDDPRQIDHFTAEGFMAEVWQEWVAQMPPDALEELDPYGAICPGPAAPGVLKAEPEAVADWLAGELAARGMPLGLVAAGRGADALAVMGWQGALHHNEWMVPMAAVVRSWEDRFGARVVGVGFNTLELSVAAPPVDHEHALHVAAEHWTFCPDNVVQGPGDLQGYAAQIMGRHAWSFWWD
>NZ_CP017717.1|WP_080036177.1|13036091_13036670_+|HAD-IA-family-hydrolase
MFPFDAVLTDFDGVLRHFDHAAQADIEARYGLPLRKTAFDPEMILPPTLGHVTEAQWVEATVAALGGGERARQAMAEFVEIAFWVDEEVRALLARAQEHVPVIIVTNAMDTLEEHIDRLGLTYFADDVVSSARVGVAKPDPRIYEIAAERAGAAPARCLFVDDRLPNVEAARALGMTGIHYRSLQDLAEVLG
>NZ_CP017717.1|WP_080036178.1|13036692_13037337_-|TenA-family-transcriptional-regulator
MSEQTFSEWLRQQCEPEWTAVVTHPFATAIIEGTAAGDAMRRYLEQDFQFVDSFTALLGAAVAAADTFEARVPYGTFLGQVATTEEKTYFHRALAELGGRTEVPLEPVTAAFRELMDEVRRSQDYLLIAAVLCVAEWCYLGWASRAAEPLPESFVHREWIELHEGAEFRAWVAFLRGELDRLGAGLGEERRREVLGVFRRAVELERAFFDMAAG
>NZ_CP017717.1|WP_080036179.1|13037447_13038605_-|TIGR03118-family-protein
MRPRIITLCAVAVVLGATLTSPAHATTRTRFDVINLVSDVQGKAPVTDPKVVNPWGLAMGKTLWVSNTGTGSATVYSGTGKKEKTEVAIPGGAPTGQVFNPGDGFTVKGKPASFIFSSPSGAISGWNAEVDPANAIIAAFTRGADYKGLELVQTEDEAFLLAADFASGRIHAFDEDFQRIHLAKWQFRDRALPRGYNAYNVAVANGSIWVAYALRDPSTGKPVFGNGKGFVSRFNASGRLTGRISRVGLNAPWGITAAPKGWSQYRNALLVGNFGDGTVQAYRSGRHLGALRTSDGKPIVLPGLWDLEPGTAATGGESSLWFSAGIDGTKHGLIGVIAPQGTKVSSNGAAGAPSSSPSSSPTHPAGHKSSAPQNQSPSQNPYGGY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP017717_26	26.2\|9486034\|27\|NZ_CP017717\|CRISPRCasFinder	9486034-9486060	27	NZ_CP017717.1	9486078-9486104	0	1.0
NZ_CP017717_40	40.2\|12542765\|24\|NZ_CP017717\|CRISPRCasFinder	12542765-12542788	24	NZ_CP017717.1	12542797-12542820	0	1.0
NZ_CP017717_43	43.2\|12956125\|16\|NZ_CP017717\|CRISPRCasFinder	12956125-12956140	16	NZ_CP017717.1	12956026-12956041	0	1.0
NZ_CP017717_44	44.1\|13028279\|25\|NZ_CP017717\|CRISPRCasFinder	13028279-13028303	25	NZ_CP017717.1	3821-3845	0	1.0
NZ_CP017717_11	11.2\|5494709\|22\|NZ_CP017717\|CRISPRCasFinder	5494709-5494730	22	NZ_CP017717.1	5494745-5494766	2	0.909
NZ_CP017717_42	42.1\|12882583\|20\|NZ_CP017717\|PILER-CR	12882583-12882602	20	NZ_CP017717.1	6642128-6642147	2	0.9

1. spacer 26.2|9486034|27|NZ_CP017717|CRISPRCasFinder matches to position: 9486078-9486104, mismatch: 0, identity: 1.0

agagaacggcgcgcccgcgagagggga	CRISPR spacer
agagaacggcgcgcccgcgagagggga	Protospacer
***************************

2. spacer 40.2|12542765|24|NZ_CP017717|CRISPRCasFinder matches to position: 12542797-12542820, mismatch: 0, identity: 1.0

gcgactcacgtctcgcgcgactca	CRISPR spacer
gcgactcacgtctcgcgcgactca	Protospacer
************************

3. spacer 43.2|12956125|16|NZ_CP017717|CRISPRCasFinder matches to position: 12956026-12956041, mismatch: 0, identity: 1.0

agcccctgcccgtgcg	CRISPR spacer
agcccctgcccgtgcg	Protospacer
****************

4. spacer 44.1|13028279|25|NZ_CP017717|CRISPRCasFinder matches to position: 3821-3845, mismatch: 0, identity: 1.0

tccggaggcgacgtcggcgggatgg	CRISPR spacer
tccggaggcgacgtcggcgggatgg	Protospacer
*************************

5. spacer 11.2|5494709|22|NZ_CP017717|CRISPRCasFinder matches to position: 5494745-5494766, mismatch: 2, identity: 0.909

cggcgaaggcacccgcccagcc	CRISPR spacer
cggtgacggcacccgcccagcc	Protospacer
***.** ***************

6. spacer 42.1|12882583|20|NZ_CP017717|PILER-CR matches to position: 6642128-6642147, mismatch: 2, identity: 0.9

acggggcgcgggttcgaggc	CRISPR spacer
acggggcgggggttcgtggc	Protospacer
******** ******* ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP017717_5	5.2\|1366741\|22\|NZ_CP017717\|CRT	1366741-1366762	22	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	637057-637078	3	0.864
NZ_CP017717_44	44.1\|13028279\|25\|NZ_CP017717\|CRISPRCasFinder	13028279-13028303	25	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	558382-558406	3	0.88
NZ_CP017717_44	44.1\|13028279\|25\|NZ_CP017717\|CRISPRCasFinder	13028279-13028303	25	MN813684	Microbacterium phage Terij, complete genome	37043-37067	3	0.88
NZ_CP017717_44	44.1\|13028279\|25\|NZ_CP017717\|CRISPRCasFinder	13028279-13028303	25	MT498055	Arthrobacter phage Bumble, complete genome	26643-26667	3	0.88
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT889372	Microbacterium phage Avocadoman, complete genome	7619-7644	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT639649	Microbacterium phage Burritobowl, complete genome	7588-7613	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK814753	Microbacterium phage BubbaBear, complete genome	7552-7577	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN329675	Microbacterium phage SansAfet, complete genome	7572-7597	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT818427	Microbacterium phage AnnaLie, complete genome	7907-7932	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT310896	Microbacterium phage Lynlen, complete genome	7575-7600	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK937610	Microbacterium phage Arroyo, complete genome	8031-8056	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT889389	Microbacterium phage DickRichards, complete genome	8055-8080	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	835238-835263	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP015867	Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence	331527-331552	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_LR134452	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 10, complete sequence	164429-164454	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP020399	Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence	20159-20184	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP022192	Yangia pacifica strain YSBP01 plasmid unnamed2, complete sequence	191304-191329	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP014598	Yangia sp. CCB-MM3 plasmid unnamed2, complete sequence	187040-187065	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP017242	Rhizobium etli 8C-3 plasmid pRsp8C3a, complete sequence	29644-29669	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KT373978	Mycobacterium phage Ukulele, complete genome	8296-8321	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919525	Mycobacterium phage Murica, complete genome	8581-8606	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF668277	Mycobacterium phage MadamMonkfish, complete genome	7959-7984	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK433262	Mycobacterium phage Nimrod, complete genome	8780-8805	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK016498	Mycobacterium phage Manda, complete genome	8811-8836	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MG872843	Mycobacterium phage Sotrice96, complete genome	9073-9098	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH651174	Mycobacterium phage Easy2Say, complete genome	9271-9296	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH000607	Mycobacterium phage RiverMonster, complete genome	8293-8318	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT723943	Mycobacterium phage Cactus, complete genome	8330-8355	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT114165	Mycobacterium phage BadStone, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MG872831	Mycobacterium phage Asriel, complete genome	7989-8014	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK757445	Mycobacterium phage Lilizi, complete genome	8240-8265	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH576953	Mycobacterium phage Hopey, complete genome	8293-8318	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KX834009	Mycobacterium phage Goldilocks, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MG099953	Mycobacterium phage Youngblood, complete genome	8706-8731	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919506	Mycobacterium phage FireRed, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK359320	Mycobacterium phage Cookies, complete genome	8990-9015	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	AY129331	Mycobacterium virus Cjw1, complete genome	9298-9323	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586043	Mycobacterium phage Buck, complete genome	9074-9099	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH536829	Mycobacterium phage TBrady12, complete genome	8525-8550	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN096364	Mycobacterium phage Tomaszewski, complete genome	8718-8743	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH590587	Mycobacterium phage xkcd, complete genome	8777-8802	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH371112	Mycobacterium phage Adnama, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919541	Mycobacterium phage YassJohnny, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KX611831	Mycobacterium phage Pharsalus, complete genome	9315-9340	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_042027	Mycobacterium phage Pumpkin, complete genome	8096-8121	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KF493883	Mycobacterium phage Mosby, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH513978	Mycobacterium phage Phaja, complete genome	8777-8802	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN428059	Mycobacterium phage Kanye, complete genome	9521-9546	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KY549152	Mycobacterium phage Maxxinista, complete genome	8008-8033	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH399778	Mycobacterium phage Icee, complete genome	8777-8802	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919529	Mycobacterium phage Sassay, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH513972	Mycobacterium phage IHOP, complete genome	8777-8802	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586051	Mycobacterium phage Myrale, complete genome	8988-9013	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK359309	Mycobacterium phage Czyszczon1, complete genome	8283-8308	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KU865303	Mycobacterium phage TeardropMSU, complete genome	9024-9049	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586041	Mycobacterium phage Elite2014, complete genome	7748-7773	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919524	Mycobacterium phage MISSy, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	EU816588	Mycobacterium phage Porky, complete genome	7853-7878	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT952854	Mycobacterium phage Miniwave, complete genome	9315-9340	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK016502	Mycobacterium phage Pat3, complete genome	7824-7849	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	JF937106	Mycobacterium phage SirDuracell, complete genome	7784-7809	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KC748969	Mycobacterium phage Phaux, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH536827	Mycobacterium phage Simpliphy, complete genome	8283-8308	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH669002	Mycobacterium phage Emmina, complete genome	7853-7878	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586035	Mycobacterium phage ChosenOne, complete genome	7748-7773	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KR080204	Mycobacterium phage Mindy, complete genome	8895-8920	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	DQ398041	Mycobacterium virus 244, complete genome	8296-8321	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MG872832	Mycobacterium phage Barbarian, complete genome	7989-8014	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_029079	Mycobacterium phage Dusk, complete genome	8777-8802	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586032	Mycobacterium phage Command613, complete genome	9386-9411	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KC661277	Mycobacterium phage Phrux, complete genome	8279-8304	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	JF937096	Mycobacterium phage Henry, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_022065	Mycobacterium phage Contagion, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KX817173	Mycobacterium phage Tuco, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK937593	Mycobacterium phage Flypotenuse, complete genome	8733-8758	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MG757160	Mycobacterium phage Kimchi, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN096361	Mycobacterium phage Gator, complete genome	8733-8758	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586013	Mycobacterium phage Traaww1, complete genome	8763-8788	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH020247	Mycobacterium phage MPhalcon, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	JN391441	Mycobacterium phage Elph10, complete genome	8008-8033	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KF306380	Mycobacterium phage DrDrey, complete genome	9024-9049	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH576956	Mycobacterium phage Inca, complete genome	7797-7822	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK620893	Mycobacterium phage HanKaySha, complete genome	8283-8308	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH779503	Mycobacterium phage Gemini, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_022969	Mycobacterium phage PhatBacter, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586019	Mycobacterium phage Stark, complete genome	8296-8321	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586050	Mycobacterium phage Lilpickle, complete genome	7748-7773	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_041850	Mycobacterium phage Eureka, complete genome	8821-8846	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KF562099	Mycobacterium phage Bruin, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK016491	Mycobacterium phage BaboJay, complete genome	8648-8673	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_028906	Mycobacterium phage Toto, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KY319168	Mycobacterium phage CrystalP, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KF562100	Mycobacterium phage HufflyPuff, complete genome	8581-8606	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MG872837	Mycobacterium phage Gage, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH536820	Mycobacterium phage Glexan, complete genome	8733-8758	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_008194	Mycobacterium phage 244, complete genome	8296-8321	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	JF937091	Mycobacterium phage Bask21, complete genome	7784-7809	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KF188414	Mycobacterium phage ABCat, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	JN006062	Mycobacterium phage Rakim, complete genome	9230-9255	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK801726	Mycobacterium phage ChotaBhai, complete genome	7784-7809	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH727557	Mycobacterium phage Paperbeatsrock, complete genome	9515-9540	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KF279417	Mycobacterium phage Quink, complete genome	8296-8321	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH399774	Mycobacterium phage DoctorDiddles, complete genome	8283-8308	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	JN382248	Mycobacterium phage Lilac, complete genome	8029-8054	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_028785	Mycobacterium phage NelitzaMV, complete genome	9186-9211	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586044	Mycobacterium phage Rimmer, complete genome	8684-8709	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586017	Mycobacterium phage OrionPax, complete genome	8283-8308	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KT020852	Mycobacterium phage NoSleep, complete genome	8280-8305	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MK559429	Mycobacterium phage Moldemort, complete genome	8283-8308	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919535	Mycobacterium phage Terminus, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_022976	Mycobacterium phage Nala, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_021305	Mycobacterium phage Murphy, complete genome	8000-8025	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MF919540	Mycobacterium phage Willez, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MT522005	Mycobacterium phage Misfit, complete genome	8625-8650	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586037	Mycobacterium phage GooberAzure, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	KC691255	Mycobacterium phage Dumbo, complete genome	8005-8030	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	EU816591	Mycobacterium phage Kostya, complete genome	9117-9142	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MN586034	Mycobacterium phage Hoonter, complete genome	8528-8553	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_022085	Mycobacterium phage Goku, complete genome	8821-8846	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NC_004681	Mycobacterium phage Cjw1, complete genome	9298-9323	4	0.846
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	MH513983	Mycobacterium phage ShereKhan, complete genome	9521-9546	4	0.846
NZ_CP017717_40	40.1\|12542715\|26\|NZ_CP017717\|CRISPRCasFinder	12542715-12542740	26	NZ_AP018666	Sphingobium amiense strain DSM 16289 plasmid pSAMIE_3, complete sequence	84645-84670	4	0.846
NZ_CP017717_40	40.1\|12542715\|26\|NZ_CP017717\|CRISPRCasFinder	12542715-12542740	26	NZ_CP023451	Rhizorhabdus dicambivorans strain Ndbn-20 plasmid p2, complete sequence	170510-170535	4	0.846
NZ_CP017717_43	43.1\|12956077\|25\|NZ_CP017717\|CRISPRCasFinder	12956077-12956101	25	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	368917-368941	4	0.84
NZ_CP017717_44	44.1\|13028279\|25\|NZ_CP017717\|CRISPRCasFinder	13028279-13028303	25	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	298006-298030	4	0.84
NZ_CP017717_22	22.1\|8447479\|26\|NZ_CP017717\|CRISPRCasFinder	8447479-8447504	26	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	500117-500142	5	0.808
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	35771-35796	5	0.808
NZ_CP017717_24	24.3\|9058370\|26\|NZ_CP017717\|CRT	9058370-9058395	26	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	88831-88856	5	0.808
NZ_CP017717_25	25.1\|9362652\|27\|NZ_CP017717\|CRISPRCasFinder	9362652-9362678	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3912315-3912341	5	0.815
NZ_CP017717_25	25.1\|9362652\|27\|NZ_CP017717\|CRISPRCasFinder	9362652-9362678	27	NZ_LR134459	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence	138395-138421	5	0.815
NZ_CP017717_26	26.2\|9486034\|27\|NZ_CP017717\|CRISPRCasFinder	9486034-9486060	27	NZ_CP032686	Rhizobium sp. CCGE531 plasmid pRCCGE531c, complete sequence	730359-730385	5	0.815
NZ_CP017717_26	26.2\|9486034\|27\|NZ_CP017717\|CRISPRCasFinder	9486034-9486060	27	NZ_CP032691	Rhizobium sp. CCGE532 plasmid pRCCGE532c, complete sequence	721665-721691	5	0.815
NZ_CP017717_43	43.1\|12956077\|25\|NZ_CP017717\|CRISPRCasFinder	12956077-12956101	25	LR134122	Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 2	330145-330169	5	0.8
NZ_CP017717_4	4.1\|1159022\|31\|NZ_CP017717\|CRISPRCasFinder	1159022-1159052	31	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	361626-361656	6	0.806
NZ_CP017717_4	4.1\|1159022\|31\|NZ_CP017717\|CRISPRCasFinder	1159022-1159052	31	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	154690-154720	6	0.806
NZ_CP017717_5	5.3\|1366792\|31\|NZ_CP017717\|CRT	1366792-1366822	31	NC_011960	Rhodobacter sphaeroides KD131 plasmid pRSKD131B, complete sequence	62251-62281	6	0.806
NZ_CP017717_5	5.3\|1366792\|31\|NZ_CP017717\|CRT	1366792-1366822	31	NC_009040	Rhodobacter sphaeroides ATCC 17029 plasmid pRSPH01, complete sequence	31118-31148	6	0.806
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	704945-704971	6	0.778
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KM879463	Arthrobacter phage vB_ArtM-ArV1, complete genome	22327-22353	6	0.778
NZ_CP017717_34	34.1\|11414807\|28\|NZ_CP017717\|PILER-CR	11414807-11414834	28	NC_019307	Streptomyces sp. W75 plasmid pCQ4, complete sequence	58684-58711	6	0.786
NZ_CP017717_4	4.1\|1159022\|31\|NZ_CP017717\|CRISPRCasFinder	1159022-1159052	31	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	26470-26500	7	0.774
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KX855962	Arthrobacter phage HumptyDumpty, complete genome	24013-24039	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MF185721	Arthrobacter phage Kabreeze, complete genome	24013-24039	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KX522650	Arthrobacter Phage Conboy, complete genome	24014-24040	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MF185723	Arthrobacter phage RosiePosie, complete genome	24016-24042	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KX670787	Arthrobacter phage Chocolat, complete genome	24015-24041	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MF668274	Arthrobacter phage JayCookie, complete genome	24016-24042	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MK494107	Arthrobacter phage Chipper1996, complete genome	24015-24041	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MF185724	Arthrobacter phage Scavito, complete genome	24013-24039	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KX670786	Arthrobacter phage Chubster, complete genome	23786-23812	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MN204499	Arthrobacter phage Mordred, complete genome	24013-24039	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	MF185725	Arthrobacter phage Tophat, complete genome	24015-24041	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KU160660	Arthrobacter phage PrincessTrina, complete genome	24016-24042	7	0.741
NZ_CP017717_8	8.2\|2783618\|27\|NZ_CP017717\|PILER-CR	2783618-2783644	27	KX855961	Arthrobacter phage EdgarPoe, complete genome	24014-24040	7	0.741
NZ_CP017717_23	23.3\|8942540\|27\|NZ_CP017717\|CRISPRCasFinder	8942540-8942566	27	NZ_CP006369	Aureimonas sp. AU20 plasmid pAU20b, complete sequence	316793-316819	7	0.741
NZ_CP017717_29	29.1\|9954615\|29\|NZ_CP017717\|CRISPRCasFinder	9954615-9954643	29	NZ_CP020932	Marinobacter salarius strain SMR5 plasmid pSMR5, complete sequence	35301-35329	7	0.759
NZ_CP017717_34	34.1\|11414807\|28\|NZ_CP017717\|PILER-CR	11414807-11414834	28	MN908693	Gordonia phage AnClar, complete genome	7525-7552	7	0.75
NZ_CP017717_34	34.1\|11414807\|28\|NZ_CP017717\|PILER-CR	11414807-11414834	28	MK801725	Gordonia phage Yago84, complete genome	7036-7063	7	0.75
NZ_CP017717_5	5.3\|1366792\|31\|NZ_CP017717\|CRT	1366792-1366822	31	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	200163-200193	8	0.742
NZ_CP017717_5	5.3\|1366792\|31\|NZ_CP017717\|CRT	1366792-1366822	31	NC_017324	Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence	709840-709870	8	0.742
NZ_CP017717_5	5.3\|1366792\|31\|NZ_CP017717\|CRT	1366792-1366822	31	NZ_CP009145	Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence	1180793-1180823	8	0.742
NZ_CP017717_5	5.3\|1366792\|31\|NZ_CP017717\|CRT	1366792-1366822	31	NZ_CP021824	Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence	1186378-1186408	8	0.742
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NC_023316	Streptomyces sp. 14R-10 plasmid pZL1, complete sequence	51738-51771	8	0.765
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_AP022334	Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49b, complete sequence	78902-78935	8	0.765
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	540862-540895	8	0.765
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	NC_013779	Nocardiopsis sp. 90127 plasmid pSQ10, complete sequence	11195-11227	8	0.758
NZ_CP017717_28	28.1\|9792934\|32\|NZ_CP017717\|CRISPRCasFinder	9792934-9792965	32	NZ_CP025432	Paracoccus zhejiangensis strain J6 plasmid pPZ02, complete sequence	194162-194193	8	0.75
NZ_CP017717_31	31.1\|10336407\|28\|NZ_CP017717\|CRISPRCasFinder	10336407-10336434	28	NC_021289	Burkholderia insecticola plasmid p1, complete sequence	198437-198464	8	0.714
NZ_CP017717_35	35.4\|11567076\|31\|NZ_CP017717\|CRISPRCasFinder	11567076-11567106	31	NC_007336	Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence	237295-237325	8	0.742
NZ_CP017717_35	35.4\|11567076\|31\|NZ_CP017717\|CRISPRCasFinder	11567076-11567106	31	NC_007336	Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence	285391-285421	8	0.742
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1031286-1031319	9	0.735
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1311901-1311934	9	0.735
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1848981-1849014	9	0.735
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	772613-772646	9	0.735
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1601215-1601248	9	0.735
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1359768-1359801	9	0.735
NZ_CP017717_35	35.4\|11567076\|31\|NZ_CP017717\|CRISPRCasFinder	11567076-11567106	31	NZ_LN997849	Magnetospirillum sp. XM-1 isolate XM1 plasmid II, complete sequence	119017-119047	9	0.71
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1525524-1525557	10	0.706
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	554097-554130	10	0.706
NZ_CP017717_17	17.1\|7470473\|34\|NZ_CP017717\|CRISPRCasFinder	7470473-7470506	34	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	174093-174126	10	0.706
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	MN284907	Gordonia phage Fireball, complete genome	55111-55143	10	0.697
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	MK864264	Gordonia phage VanDeWege, complete genome	55160-55192	10	0.697
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	MH479917	Gordonia phage KimmyK, complete genome	54942-54974	10	0.697
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	KX557286	Gordonia phage Twister6, complete genome	53992-54024	10	0.697
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	MK864267	Gordonia phage Valary, complete genome	55635-55667	10	0.697
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	MK967381	Gordonia phage RogerDodger, complete genome	55310-55342	10	0.697
NZ_CP017717_23	23.2\|8942483\|33\|NZ_CP017717\|CRISPRCasFinder	8942483-8942515	33	NC_030913	Gordonia phage Wizard, complete genome	54495-54527	10	0.697
NZ_CP017717_28	28.1\|9792934\|32\|NZ_CP017717\|CRISPRCasFinder	9792934-9792965	32	NZ_CP018464	Xanthomonas euvesicatoria strain LMG930 plasmid pLMG930.1, complete sequence	178984-179015	10	0.688

1. spacer 5.2|1366741|22|NZ_CP017717|CRT matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 3, identity: 0.864

cccctgcccggccgcccgcaca	CRISPR spacer
atcctgcccggccgcccgcacg	Protospacer
 .*******************.

2. spacer 44.1|13028279|25|NZ_CP017717|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 3, identity: 0.88

tccggaggcgacgtcggcgggatgg	CRISPR spacer
accggaggcgaggtcggccggatgg	Protospacer
 ********** ****** ******

3. spacer 44.1|13028279|25|NZ_CP017717|CRISPRCasFinder matches to MN813684 (Microbacterium phage Terij, complete genome) position: , mismatch: 3, identity: 0.88

tccggaggcgacgtcggcgggatgg	CRISPR spacer
tccggcggcggcgtcggcgggatcg	Protospacer
***** ****.************ *

4. spacer 44.1|13028279|25|NZ_CP017717|CRISPRCasFinder matches to MT498055 (Arthrobacter phage Bumble, complete genome) position: , mismatch: 3, identity: 0.88

tccggaggcgacgtcggcgggatgg	CRISPR spacer
tccggcggcgacgtcggcggggagg	Protospacer
***** ***************. **

5. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT889372 (Microbacterium phage Avocadoman, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgagggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

6. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT639649 (Microbacterium phage Burritobowl, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgagggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

7. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK814753 (Microbacterium phage BubbaBear, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgaaggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

8. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN329675 (Microbacterium phage SansAfet, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
tgagggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

9. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT818427 (Microbacterium phage AnnaLie, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
tgagggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

10. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT310896 (Microbacterium phage Lynlen, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgaaggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

11. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK937610 (Microbacterium phage Arroyo, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgagggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

12. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT889389 (Microbacterium phage DickRichards, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
tgagggcgacttcttcgtgaacggcg	Protospacer
 *. ************* ********

13. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gctcggcgacttcttcgggtaccgcg	Protospacer
*  **************** ** ***

14. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP015867 (Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgacgacgacttcttcggcaacggcg	Protospacer
 *.**.************ *******

15. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_LR134452 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 10, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gagcggcgacgtcttcggcaacggca	Protospacer
*.******** ******* ******.

16. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP020399 (Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cgccggctacttcttcgcgaacggcg	Protospacer
 * **** ********* ********

17. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP022192 (Yangia pacifica strain YSBP01 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcgacctcttcgggatcgaag	Protospacer
**********.********* **. *

18. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP014598 (Yangia sp. CCB-MM3 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcgacttcttctcgaacgaag	Protospacer
****************  *****. *

19. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP017242 (Rhizobium etli 8C-3 plasmid pRsp8C3a, complete sequence) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gttcgacgacttcttcgagaacggcg	Protospacer
*  **.***********.********

20. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KT373978 (Mycobacterium phage Ukulele, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

21. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919525 (Mycobacterium phage Murica, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

22. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF668277 (Mycobacterium phage MadamMonkfish, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

23. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK433262 (Mycobacterium phage Nimrod, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

24. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK016498 (Mycobacterium phage Manda, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

25. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MG872843 (Mycobacterium phage Sotrice96, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

26. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH651174 (Mycobacterium phage Easy2Say, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

27. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH000607 (Mycobacterium phage RiverMonster, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

28. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT723943 (Mycobacterium phage Cactus, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

29. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT114165 (Mycobacterium phage BadStone, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

30. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MG872831 (Mycobacterium phage Asriel, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

31. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK757445 (Mycobacterium phage Lilizi, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

32. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH576953 (Mycobacterium phage Hopey, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

33. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KX834009 (Mycobacterium phage Goldilocks, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

34. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MG099953 (Mycobacterium phage Youngblood, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

35. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919506 (Mycobacterium phage FireRed, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

36. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK359320 (Mycobacterium phage Cookies, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

37. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to AY129331 (Mycobacterium virus Cjw1, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

38. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586043 (Mycobacterium phage Buck, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

39. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH536829 (Mycobacterium phage TBrady12, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

40. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN096364 (Mycobacterium phage Tomaszewski, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

41. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH590587 (Mycobacterium phage xkcd, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

42. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH371112 (Mycobacterium phage Adnama, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

43. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919541 (Mycobacterium phage YassJohnny, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

44. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KX611831 (Mycobacterium phage Pharsalus, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

45. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_042027 (Mycobacterium phage Pumpkin, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

46. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KF493883 (Mycobacterium phage Mosby, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

47. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH513978 (Mycobacterium phage Phaja, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

48. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN428059 (Mycobacterium phage Kanye, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

49. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KY549152 (Mycobacterium phage Maxxinista, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

50. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH399778 (Mycobacterium phage Icee, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

51. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919529 (Mycobacterium phage Sassay, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

52. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH513972 (Mycobacterium phage IHOP, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

53. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586051 (Mycobacterium phage Myrale, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

54. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK359309 (Mycobacterium phage Czyszczon1, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

55. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KU865303 (Mycobacterium phage TeardropMSU, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

56. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586041 (Mycobacterium phage Elite2014, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

57. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919524 (Mycobacterium phage MISSy, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

58. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to EU816588 (Mycobacterium phage Porky, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

59. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT952854 (Mycobacterium phage Miniwave, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

60. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK016502 (Mycobacterium phage Pat3, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

61. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to JF937106 (Mycobacterium phage SirDuracell, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

62. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KC748969 (Mycobacterium phage Phaux, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

63. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH536827 (Mycobacterium phage Simpliphy, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

64. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH669002 (Mycobacterium phage Emmina, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

65. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586035 (Mycobacterium phage ChosenOne, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

66. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KR080204 (Mycobacterium phage Mindy, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

67. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to DQ398041 (Mycobacterium virus 244, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

68. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MG872832 (Mycobacterium phage Barbarian, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

69. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_029079 (Mycobacterium phage Dusk, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

70. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586032 (Mycobacterium phage Command613, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

71. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KC661277 (Mycobacterium phage Phrux, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

72. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to JF937096 (Mycobacterium phage Henry, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

73. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_022065 (Mycobacterium phage Contagion, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

74. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KX817173 (Mycobacterium phage Tuco, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

75. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK937593 (Mycobacterium phage Flypotenuse, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

76. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MG757160 (Mycobacterium phage Kimchi, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

77. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN096361 (Mycobacterium phage Gator, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

78. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586013 (Mycobacterium phage Traaww1, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

79. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH020247 (Mycobacterium phage MPhalcon, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

80. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to JN391441 (Mycobacterium phage Elph10, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

81. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KF306380 (Mycobacterium phage DrDrey, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

82. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH576956 (Mycobacterium phage Inca, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

83. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK620893 (Mycobacterium phage HanKaySha, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

84. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH779503 (Mycobacterium phage Gemini, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

85. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_022969 (Mycobacterium phage PhatBacter, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

86. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586019 (Mycobacterium phage Stark, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

87. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586050 (Mycobacterium phage Lilpickle, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

88. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_041850 (Mycobacterium phage Eureka, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

89. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KF562099 (Mycobacterium phage Bruin, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

90. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK016491 (Mycobacterium phage BaboJay, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

91. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_028906 (Mycobacterium phage Toto, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

92. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KY319168 (Mycobacterium phage CrystalP, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

93. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KF562100 (Mycobacterium phage HufflyPuff, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

94. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MG872837 (Mycobacterium phage Gage, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

95. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH536820 (Mycobacterium phage Glexan, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

96. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_008194 (Mycobacterium phage 244, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

97. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to JF937091 (Mycobacterium phage Bask21, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

98. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KF188414 (Mycobacterium phage ABCat, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

99. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to JN006062 (Mycobacterium phage Rakim, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

100. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK801726 (Mycobacterium phage ChotaBhai, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

101. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH727557 (Mycobacterium phage Paperbeatsrock, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

102. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KF279417 (Mycobacterium phage Quink, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

103. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH399774 (Mycobacterium phage DoctorDiddles, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

104. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to JN382248 (Mycobacterium phage Lilac, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

105. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_028785 (Mycobacterium phage NelitzaMV, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

106. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586044 (Mycobacterium phage Rimmer, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

107. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586017 (Mycobacterium phage OrionPax, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

108. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KT020852 (Mycobacterium phage NoSleep, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

109. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MK559429 (Mycobacterium phage Moldemort, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

110. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919535 (Mycobacterium phage Terminus, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

111. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_022976 (Mycobacterium phage Nala, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

112. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_021305 (Mycobacterium phage Murphy, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

113. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MF919540 (Mycobacterium phage Willez, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

114. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MT522005 (Mycobacterium phage Misfit, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

115. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586037 (Mycobacterium phage GooberAzure, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

116. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to KC691255 (Mycobacterium phage Dumbo, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

117. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to EU816591 (Mycobacterium phage Kostya, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

118. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MN586034 (Mycobacterium phage Hoonter, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

119. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_022085 (Mycobacterium phage Goku, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

120. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NC_004681 (Mycobacterium phage Cjw1, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

121. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to MH513983 (Mycobacterium phage ShereKhan, complete genome) position: , mismatch: 4, identity: 0.846

gggcggcgacttcttcgggaacggcg	CRISPR spacer
gggcggcaacttcttcggcaacgcct	Protospacer
*******.********** **** *

122. spacer 40.1|12542715|26|NZ_CP017717|CRISPRCasFinder matches to NZ_AP018666 (Sphingobium amiense strain DSM 16289 plasmid pSAMIE_3, complete sequence) position: , mismatch: 4, identity: 0.846

cccgctgaccgcctcgcttgcagcac	CRISPR spacer
ggcgctggccgcctcgcgtgcagcac	Protospacer
  *****.********* ********

123. spacer 40.1|12542715|26|NZ_CP017717|CRISPRCasFinder matches to NZ_CP023451 (Rhizorhabdus dicambivorans strain Ndbn-20 plasmid p2, complete sequence) position: , mismatch: 4, identity: 0.846

cccgctgaccgcctcgcttgcagcac	CRISPR spacer
ggcgctggccgcctcgcgtgcagcac	Protospacer
  *****.********* ********

124. spacer 43.1|12956077|25|NZ_CP017717|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 4, identity: 0.84

gtctggcatcggcggcgggatagca	CRISPR spacer
ctctggcatcggccgcgggatcgcc	Protospacer
 ************ ******* **

125. spacer 44.1|13028279|25|NZ_CP017717|CRISPRCasFinder matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 4, identity: 0.84

tccggaggcgacgtcggcgggatgg	CRISPR spacer
gacggaggcgttgtcggcgggatgg	Protospacer
  ******** .*************

126. spacer 22.1|8447479|26|NZ_CP017717|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.808

acccccggcacaacgctgaccccgca	CRISPR spacer
ggccccggcacgccgctgaccccgcg	Protospacer
. *********. ************.

127. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.808

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cttcggcgacttcatcgcgaacggcg	Protospacer
   ********** *** ********

128. spacer 24.3|9058370|26|NZ_CP017717|CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.808

gggcggcgacttcttcgggaacggcg	CRISPR spacer
cttcggcgacttcatcgcgaacggcg	Protospacer
   ********** *** ********

129. spacer 25.1|9362652|27|NZ_CP017717|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

tcagccgggggtcggacgcggcctttc	CRISPR spacer
gcagccgggggtcggacccggcctccg	Protospacer
 **************** ******..

130. spacer 25.1|9362652|27|NZ_CP017717|CRISPRCasFinder matches to NZ_LR134459 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence) position: , mismatch: 5, identity: 0.815

tcagccgggggtcggacgcggcctttc	CRISPR spacer
gcagcccgaggtcggacgcggccttga	Protospacer
 ***** *.****************

131. spacer 26.2|9486034|27|NZ_CP017717|CRISPRCasFinder matches to NZ_CP032686 (Rhizobium sp. CCGE531 plasmid pRCCGE531c, complete sequence) position: , mismatch: 5, identity: 0.815

agagaacggcgcgcccgcgagagggga	CRISPR spacer
cgagaacggcgcgcccacgagagcgat	Protospacer
 ***************.****** *.

132. spacer 26.2|9486034|27|NZ_CP017717|CRISPRCasFinder matches to NZ_CP032691 (Rhizobium sp. CCGE532 plasmid pRCCGE532c, complete sequence) position: , mismatch: 5, identity: 0.815

agagaacggcgcgcccgcgagagggga	CRISPR spacer
cgagaacggcgcgcccacgagagcgat	Protospacer
 ***************.****** *.

133. spacer 43.1|12956077|25|NZ_CP017717|CRISPRCasFinder matches to LR134122 (Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 2) position: , mismatch: 5, identity: 0.8

gtctggcatcggcggcgggatagca	CRISPR spacer
gtctggcatcggcggcggcattttc	Protospacer
****************** **  .

134. spacer 4.1|1159022|31|NZ_CP017717|CRISPRCasFinder matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

tcacctggtccgcgtggttcgcaccgtccgc	CRISPR spacer
tcaactggtccgcgtggttcgcagcggtggg	Protospacer
*** ******************* ** . *

135. spacer 4.1|1159022|31|NZ_CP017717|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 6, identity: 0.806

tcacctggtccgcgtggttcgcaccgtccgc	CRISPR spacer
tcaactggtccgcgtggttcgcagcggtggg	Protospacer
*** ******************* ** . *

136. spacer 5.3|1366792|31|NZ_CP017717|CRT matches to NC_011960 (Rhodobacter sphaeroides KD131 plasmid pRSKD131B, complete sequence) position: , mismatch: 6, identity: 0.806

ggccgggccagtcgtcgcagcaggagcccgc	CRISPR spacer
aggcccgccagtcgtcccaggaggagcccgc	Protospacer
.* *  ********** *** **********

137. spacer 5.3|1366792|31|NZ_CP017717|CRT matches to NC_009040 (Rhodobacter sphaeroides ATCC 17029 plasmid pRSPH01, complete sequence) position: , mismatch: 6, identity: 0.806

ggccgggccagtcgtcgcagcaggagcccgc	CRISPR spacer
agacccgccagtcgtcccaggaggagcccgc	Protospacer
.* *  ********** *** **********

138. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 6, identity: 0.778

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
attcgccgctcgcgctgaccgccctgc	Protospacer
.***.***************.***.

139. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KM879463 (Arthrobacter phage vB_ArtM-ArV1, complete genome) position: , mismatch: 6, identity: 0.778

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
gcgttccgctcgcgctgaccacaccca	Protospacer
*. . ***************** ***.

140. spacer 34.1|11414807|28|NZ_CP017717|PILER-CR matches to NC_019307 (Streptomyces sp. W75 plasmid pCQ4, complete sequence) position: , mismatch: 6, identity: 0.786

ggccgtggagccgttcgtgctacccgag	CRISPR spacer
ggcgggggagccgttcgtgctacatccg	Protospacer
*** * ***************** .  *

141. spacer 4.1|1159022|31|NZ_CP017717|CRISPRCasFinder matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.774

tcacctggtccgcgtggttcgcaccgtccgc	CRISPR spacer
gaccctggtccgcgtggtgcgcaccgccacc	Protospacer
   *************** *******.*  *

142. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KX855962 (Arthrobacter phage HumptyDumpty, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

143. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MF185721 (Arthrobacter phage Kabreeze, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

144. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KX522650 (Arthrobacter Phage Conboy, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

145. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MF185723 (Arthrobacter phage RosiePosie, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

146. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KX670787 (Arthrobacter phage Chocolat, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

147. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MF668274 (Arthrobacter phage JayCookie, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

148. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MK494107 (Arthrobacter phage Chipper1996, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

149. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MF185724 (Arthrobacter phage Scavito, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

150. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KX670786 (Arthrobacter phage Chubster, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

151. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MN204499 (Arthrobacter phage Mordred, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

152. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to MF185725 (Arthrobacter phage Tophat, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

153. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KU160660 (Arthrobacter phage PrincessTrina, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

154. spacer 8.2|2783618|27|NZ_CP017717|PILER-CR matches to KX855961 (Arthrobacter phage EdgarPoe, complete genome) position: , mismatch: 7, identity: 0.741

gttcaccgctcgcgctgaccacccccg	CRISPR spacer
ccgttccgctcgcgctgaccacaccca	Protospacer
 . . ***************** ***.

155. spacer 23.3|8942540|27|NZ_CP017717|CRISPRCasFinder matches to NZ_CP006369 (Aureimonas sp. AU20 plasmid pAU20b, complete sequence) position: , mismatch: 7, identity: 0.741

tggacgcaacccagcctcgcgggcggg	CRISPR spacer
atccggcaacccagcgtcgcgggcggc	Protospacer
     ********** **********

156. spacer 29.1|9954615|29|NZ_CP017717|CRISPRCasFinder matches to NZ_CP020932 (Marinobacter salarius strain SMR5 plasmid pSMR5, complete sequence) position: , mismatch: 7, identity: 0.759

gtacgcggtcaggtgctcagacctgccca	CRISPR spacer
gtacgcggtcaggtgttcagaggcattca	Protospacer
***************.*****  ....**

157. spacer 34.1|11414807|28|NZ_CP017717|PILER-CR matches to MN908693 (Gordonia phage AnClar, complete genome) position: , mismatch: 7, identity: 0.75

ggccgtggagccgttcgtgctacccgag	CRISPR spacer
acaggtggagccgttcgtgctgccctcg	Protospacer
.   *****************.***  *

158. spacer 34.1|11414807|28|NZ_CP017717|PILER-CR matches to MK801725 (Gordonia phage Yago84, complete genome) position: , mismatch: 7, identity: 0.75

ggccgtggagccgttcgtgctacccgag	CRISPR spacer
acaggtggagccgttcgtgctgccctcg	Protospacer
.   *****************.***  *

159. spacer 5.3|1366792|31|NZ_CP017717|CRT matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.742

ggccgggccagtcgtcgcagcaggagcccgc	CRISPR spacer
cgccgggcctgtcctcgcagcaggcccagga	Protospacer
 ******** *** **********  *  *

160. spacer 5.3|1366792|31|NZ_CP017717|CRT matches to NC_017324 (Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence) position: , mismatch: 8, identity: 0.742

ggccgggccagtcgtcgcagcaggagcccgc	CRISPR spacer
cgctccaacagtcgtcgccgcaggagaccgc	Protospacer
 **.  . ********** ******* ****

161. spacer 5.3|1366792|31|NZ_CP017717|CRT matches to NZ_CP009145 (Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.742

ggccgggccagtcgtcgcagcaggagcccgc	CRISPR spacer
cgctccaacagtcgtcgccgcaggagaccgc	Protospacer
 **.  . ********** ******* ****

162. spacer 5.3|1366792|31|NZ_CP017717|CRT matches to NZ_CP021824 (Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.742

ggccgggccagtcgtcgcagcaggagcccgc	CRISPR spacer
cgctccaacagtcgtcgccgcaggagaccgc	Protospacer
 **.  . ********** ******* ****

163. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NC_023316 (Streptomyces sp. 14R-10 plasmid pZL1, complete sequence) position: , mismatch: 8, identity: 0.765

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
tgaagcgccggggtccggccgccggtcggcggcc	Protospacer
.*. *   **** **************** ****

164. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_AP022334 (Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49b, complete sequence) position: , mismatch: 8, identity: 0.765

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
aggcggcattggctccggccgccggtacgctggc	Protospacer
 *******. ****************  *  * *

165. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.765

cggcggcacgggctccggccgccggtcggaggcc--	CRISPR spacer
agcacgcacgggctctggccgtcggtcg--ggccgg	Protospacer
 *   **********.*****.******  ****

166. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to NC_013779 (Nocardiopsis sp. 90127 plasmid pSQ10, complete sequence) position: , mismatch: 8, identity: 0.758

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
ccgcgatgtggcgggcggccctggaggagctgg	Protospacer
* *    * *******.** *************

167. spacer 28.1|9792934|32|NZ_CP017717|CRISPRCasFinder matches to NZ_CP025432 (Paracoccus zhejiangensis strain J6 plasmid pPZ02, complete sequence) position: , mismatch: 8, identity: 0.75

cgaacggccgctgtttcgtccgaacagccgct	CRISPR spacer
cggcgggccgctgtttcgcccgatcagccagg	Protospacer
**.  *************.**** *****.

168. spacer 31.1|10336407|28|NZ_CP017717|CRISPRCasFinder matches to NC_021289 (Burkholderia insecticola plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.714

cccacgacgggctcggatcatccgcgat	CRISPR spacer
gtgctgacgggcgcggatcatccgcgcg	Protospacer
 .  .******* *************

169. spacer 35.4|11567076|31|NZ_CP017717|CRISPRCasFinder matches to NC_007336 (Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.742

gcccatctcccttgcgccacccatcccccta	CRISPR spacer
tcgtatctcccttgcgccagcgatcccacat	Protospacer
 * .*************** * ***** *

170. spacer 35.4|11567076|31|NZ_CP017717|CRISPRCasFinder matches to NC_007336 (Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.742

gcccatctcccttgcgccacccatcccccta	CRISPR spacer
tcgtatctcccttgcgccagcgatcccacat	Protospacer
 * .*************** * ***** *

171. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.735

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
cagggagtagggcgccggccgccggtcggtggcg	Protospacer
*.* *.   **** *************** ***

172. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 9, identity: 0.735

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
cagggagtagggcgccggccgccggtcggtggcg	Protospacer
*.* *.   **** *************** ***

173. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.735

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
cagggagtagggcgccggccgccggtcggtggcg	Protospacer
*.* *.   **** *************** ***

174. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.735

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
cagggagtagggcgccggccgccggtcggtggcg	Protospacer
*.* *.   **** *************** ***

175. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.735

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
cagggagtagggcgccggccgccggtcggtggcg	Protospacer
*.* *.   **** *************** ***

176. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 9, identity: 0.735

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
cagggagtagggcgccggccgccggtcggtggcg	Protospacer
*.* *.   **** *************** ***

177. spacer 35.4|11567076|31|NZ_CP017717|CRISPRCasFinder matches to NZ_LN997849 (Magnetospirillum sp. XM-1 isolate XM1 plasmid II, complete sequence) position: , mismatch: 9, identity: 0.71

gcccatctcccttgcgccacccatcccccta	CRISPR spacer
ctccttctcccttgcgccagccatcctggcc	Protospacer
 .** ************** ******.  .

178. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 10, identity: 0.706

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
tgcgttgacgggctccggcagcaggtcggagacg	Protospacer
.*     ************ ** ********.*

179. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 10, identity: 0.706

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
gagcggcacgggctccagcagccggtgctggtgc	Protospacer
 .**************.** ******   .*  *

180. spacer 17.1|7470473|34|NZ_CP017717|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 10, identity: 0.706

cggcggcacgggctccggccgccggtcggaggcc	CRISPR spacer
gagcggcacgggctccagcagccggtgctggtgc	Protospacer
 .**************.** ******   .*  *

181. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to MN284907 (Gordonia phage Fireball, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

182. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to MK864264 (Gordonia phage VanDeWege, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

183. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to MH479917 (Gordonia phage KimmyK, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

184. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to KX557286 (Gordonia phage Twister6, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

185. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to MK864267 (Gordonia phage Valary, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

186. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to MK967381 (Gordonia phage RogerDodger, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

187. spacer 23.2|8942483|33|NZ_CP017717|CRISPRCasFinder matches to NC_030913 (Gordonia phage Wizard, complete genome) position: , mismatch: 10, identity: 0.697

cgggtcaggggcgggcagcactggaggagctgg	CRISPR spacer
tgaccggacggcgggcagcgctggtggagctgg	Protospacer
.*. . .. **********.**** ********

188. spacer 28.1|9792934|32|NZ_CP017717|CRISPRCasFinder matches to NZ_CP018464 (Xanthomonas euvesicatoria strain LMG930 plasmid pLMG930.1, complete sequence) position: , mismatch: 10, identity: 0.688

cgaacggccgctgtttcgtccgaacagccgct	CRISPR spacer
aatccggcggctgtttcgttcgaacagttttt	Protospacer
 .  **** **********.*******.. .*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3234337 : 3294032

Bacillus_phage(50.0%)

protease,transposase,integrase

attL 3279492:3279508|attR 3292420:3292436

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080046718.1\|3234337_3235459_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_080038674.1\|3236769_3237207_-	DUF1905 domain-containing protein	NA	NA	NA	NA
WP_080038675.1\|3237215_3237626_-	VOC family protein	NA	NA	NA	NA
WP_080038676.1\|3237722_3238175_-	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_080046729.1\|3238318_3239185_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_155127194.1\|3239590_3239821_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_080046730.1\|3240265_3240919_+	response regulator	NA	NA	NA	NA
WP_155127197.1\|3242205_3242514_-	hypothetical protein	NA	NA	NA	NA
WP_080038680.1\|3242623_3243316_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_080038681.1\|3243629_3243872_-	hypothetical protein	NA	NA	NA	NA
WP_080038682.1\|3244037_3245252_-	serine hydrolase	NA	NA	NA	NA
WP_080038683.1\|3245397_3246006_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_080038684.1\|3246641_3246854_+	hypothetical protein	NA	NA	NA	NA
WP_155127200.1\|3247007_3247313_+	hypothetical protein	NA	NA	NA	NA
WP_080038686.1\|3248430_3249681_+	bifunctional glycosyltransferase family 2/GtrA family protein	NA	NA	NA	NA
WP_080038687.1\|3249688_3251851_+	phospholipid carrier-dependent glycosyltransferase	NA	NA	NA	NA
WP_080038688.1\|3251905_3252607_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.7e-36	37.1
WP_080038689.1\|3252603_3254061_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	7.6e-15	24.6
WP_080038690.1\|3254147_3255065_+	polyphosphate polymerase domain-containing protein	NA	NA	NA	NA
WP_080038691.1\|3255071_3255749_+	DUF4956 domain-containing protein	NA	NA	NA	NA
WP_080038692.1\|3255753_3257469_+	hypothetical protein	NA	NA	NA	NA
WP_080038693.1\|3257552_3258473_+	dioxygenase	NA	NA	NA	NA
WP_155127203.1\|3260408_3261326_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_155127206.1\|3261447_3261777_+	hypothetical protein	NA	NA	NA	NA
WP_155127209.1\|3261773_3265856_-	hypothetical protein	G1FGA4	Mycobacterium_phage	8.1e-06	40.9
WP_155127212.1\|3265866_3266208_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_080038696.1\|3266868_3267057_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_155127215.1\|3267194_3267542_+	hypothetical protein	NA	NA	NA	NA
WP_080038698.1\|3268248_3268884_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_080038699.1\|3269047_3270205_+	FAD-dependent monooxygenase	NA	NA	NA	NA
WP_155127218.1\|3270284_3270941_-	hypothetical protein	NA	NA	NA	NA
WP_080038700.1\|3271136_3271487_-	hypothetical protein	NA	NA	NA	NA
WP_080038701.1\|3271533_3271761_-	hypothetical protein	NA	NA	NA	NA
WP_080038702.1\|3272331_3274752_-	hypothetical protein	NA	NA	NA	NA
WP_080038703.1\|3275195_3275543_-	hypothetical protein	NA	NA	NA	NA
WP_080038704.1\|3275545_3276157_-	hypothetical protein	NA	NA	NA	NA
WP_080038705.1\|3276272_3276953_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_080038706.1\|3277328_3278105_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_080038707.1\|3278260_3278590_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_080046733.1\|3278693_3279071_+	hypothetical protein	NA	NA	NA	NA
3279492:3279508	attL	NA	NA	NA	NA
WP_155127222.1\|3279971_3280292_-	hypothetical protein	NA	NA	NA	NA
WP_155127225.1\|3281905_3283513_-	hypothetical protein	NA	NA	NA	NA
WP_080038708.1\|3283517_3283838_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_080038709.1\|3283834_3284275_-	hypothetical protein	NA	NA	NA	NA
WP_080046735.1\|3284271_3285360_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_080038710.1\|3285735_3287325_-	NAD(P)-binding protein	A0A1V0SI18	Klosneuvirus	3.6e-34	28.9
WP_080038711.1\|3287450_3288071_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_155127228.1\|3289516_3290446_-	hypothetical protein	NA	NA	NA	NA
WP_080046736.1\|3290954_3291533_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_155127231.1\|3292025_3292565_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
3292420:3292436	attR	NA	NA	NA	NA
WP_155127234.1\|3292612_3293215_+	hypothetical protein	NA	NA	NA	NA
WP_155127236.1\|3293204_3294032_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_2

3747974 : 3773387

uncultured_Caudovirales_phage(33.33%)

transposase,integrase,tail

attL 3741562:3741579|attR 3781700:3781717

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3741562:3741579	attL	NA	NA	NA	NA
WP_080039106.1\|3747974_3748256_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_080039107.1\|3748419_3749229_+	hypothetical protein	NA	NA	NA	NA
WP_155127405.1\|3749246_3749432_+	hypothetical protein	NA	NA	NA	NA
WP_155127408.1\|3750111_3750267_+	hypothetical protein	NA	NA	NA	NA
WP_080039108.1\|3750429_3755637_-	relaxase domain-containing protein	NA	NA	NA	NA
WP_080039109.1\|3757302_3757848_+	GrpB family protein	NA	NA	NA	NA
WP_080039110.1\|3758169_3758460_-	hypothetical protein	NA	NA	NA	NA
WP_080039111.1\|3758537_3759023_-	single-stranded DNA-binding protein	A0A2H4JEL4	uncultured_Caudovirales_phage	1.0e-40	63.1
WP_080039112.1\|3759114_3759306_-	hypothetical protein	NA	NA	NA	NA
WP_080039113.1\|3760018_3760465_+	hypothetical protein	NA	NA	NA	NA
WP_155129681.1\|3760504_3760876_+	anti-sigma factor antagonist	NA	NA	NA	NA
WP_080039115.1\|3761157_3761631_-\|tail	lamin tail domain-containing protein	NA	NA	NA	NA
WP_155127411.1\|3761833_3761983_-	hypothetical protein	NA	NA	NA	NA
WP_080039116.1\|3762284_3764552_+	hypothetical protein	NA	NA	NA	NA
WP_155127414.1\|3764912_3765329_+	hypothetical protein	NA	NA	NA	NA
WP_080039118.1\|3765325_3767623_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_155127361.1\|3767702_3769163_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.5e-34	38.7
WP_155127417.1\|3769557_3770931_+	hypothetical protein	NA	NA	NA	NA
WP_155127420.1\|3771052_3771208_+	hypothetical protein	NA	NA	NA	NA
WP_155127423.1\|3771204_3771585_+	hypothetical protein	NA	NA	NA	NA
WP_080046777.1\|3771434_3771980_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_080039121.1\|3771688_3772141_+\|integrase	site-specific integrase	A0A1U9WS15	Gordonia_phage	2.9e-05	44.4
WP_080046778.1\|3772367_3773387_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
3781700:3781717	attR	NA	NA	NA	NA

DBSCAN-SWA_3

3845834 : 3918621

uncultured_virus(37.5%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_155129687.1\|3845834_3847340_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_080039173.1\|3848429_3848723_-	hypothetical protein	NA	NA	NA	NA
WP_080039174.1\|3848927_3849629_-	response regulator transcription factor	NA	NA	NA	NA
WP_080039175.1\|3850514_3851144_-	response regulator transcription factor	NA	NA	NA	NA
WP_155127489.1\|3853618_3855073_-\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	9.6e-10	27.2
WP_080039177.1\|3855589_3856288_+	hypothetical protein	NA	NA	NA	NA
WP_155129687.1\|3856421_3857927_+\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_155127492.1\|3858106_3858742_+	hypothetical protein	A0A218MNI5	uncultured_virus	1.9e-34	38.6
WP_080039179.1\|3859048_3860146_-	DUF4192 domain-containing protein	NA	NA	NA	NA
WP_080039180.1\|3860193_3860802_-	VWA domain-containing protein	A0A222YU51	Streptomyces_phage	1.7e-21	37.2
WP_080039181.1\|3860829_3861510_-	hypothetical protein	NA	NA	NA	NA
WP_080039182.1\|3861551_3862433_-	hypothetical protein	NA	NA	NA	NA
WP_080039183.1\|3862533_3863004_-	hypothetical protein	NA	NA	NA	NA
WP_080046781.1\|3863045_3864161_-	DUF932 domain-containing protein	A0A140G6E9	Arthrobacter_phage	1.8e-96	49.6
WP_080039184.1\|3864227_3865076_-	hypothetical protein	NA	NA	NA	NA
WP_080039185.1\|3865217_3865538_-	hypothetical protein	NA	NA	NA	NA
WP_080039186.1\|3865621_3867361_-	hypothetical protein	NA	NA	NA	NA
WP_080039187.1\|3867510_3867972_-	hypothetical protein	NA	NA	NA	NA
WP_155127495.1\|3869478_3873135_-	AAA family ATPase	NA	NA	NA	NA
WP_080039189.1\|3875123_3876113_-	amidohydrolase family protein	NA	NA	NA	NA
WP_155127498.1\|3876143_3877187_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_080039191.1\|3877221_3878802_-	bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase	NA	NA	NA	NA
WP_080039192.1\|3878798_3880682_-	acyl-CoA synthetase	NA	NA	NA	NA
WP_080046782.1\|3880719_3881832_-	2,3-dihydroxybiphenyl 1,2-dioxygenase	NA	NA	NA	NA
WP_080039193.1\|3881845_3882784_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_155129690.1\|3882942_3883653_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_080039195.1\|3883628_3884480_-	hypothetical protein	NA	NA	NA	NA
WP_080046783.1\|3884548_3885445_-	DNA-binding protein	NA	NA	NA	NA
WP_080039196.1\|3885900_3886773_+	hypothetical protein	NA	NA	NA	NA
WP_080039197.1\|3886769_3887648_+	hypothetical protein	NA	NA	NA	NA
WP_080039198.1\|3887853_3888873_+	phosphotransferase	NA	NA	NA	NA
WP_080039199.1\|3889086_3890076_+	hypothetical protein	NA	NA	NA	NA
WP_080039200.1\|3890250_3890910_-	hypothetical protein	NA	NA	NA	NA
WP_080039201.1\|3891083_3891521_-	STAS domain-containing protein	NA	NA	NA	NA
WP_080046784.1\|3891744_3893196_+\|transposase	transposase	NA	NA	NA	NA
WP_080039202.1\|3893474_3893741_-	hypothetical protein	NA	NA	NA	NA
WP_080039203.1\|3893823_3894003_-	hypothetical protein	NA	NA	NA	NA
WP_155127501.1\|3893999_3894962_-	hypothetical protein	NA	NA	NA	NA
WP_155127504.1\|3895173_3896325_-	hypothetical protein	NA	NA	NA	NA
WP_080039206.1\|3896321_3897371_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_080039207.1\|3897571_3898477_-	phosphotransferase	NA	NA	NA	NA
WP_080039208.1\|3898623_3898944_-	hypothetical protein	NA	NA	NA	NA
WP_080039209.1\|3899295_3900147_-	hypothetical protein	NA	NA	NA	NA
WP_080039210.1\|3900161_3900455_-	hypothetical protein	NA	NA	NA	NA
WP_080039211.1\|3900519_3901755_-	helix-turn-helix domain-containing protein	A0A2H5BLG8	Streptomyces_phage	1.2e-05	24.1
WP_155127507.1\|3901887_3902763_+	hypothetical protein	NA	NA	NA	NA
WP_080039213.1\|3902928_3903480_+	flavoprotein	NA	NA	NA	NA
WP_080039214.1\|3904072_3904984_-	phosphotransferase	NA	NA	NA	NA
WP_080039215.1\|3904980_3905457_-	hypothetical protein	NA	NA	NA	NA
WP_155127510.1\|3905859_3906015_-	hypothetical protein	NA	NA	NA	NA
WP_080039217.1\|3906247_3906541_-	hypothetical protein	NA	NA	NA	NA
WP_155129693.1\|3908527_3909124_+	YdcF family protein	NA	NA	NA	NA
WP_080039220.1\|3909065_3909905_+	hypothetical protein	NA	NA	NA	NA
WP_080039221.1\|3911094_3912327_+	MFS transporter	NA	NA	NA	NA
WP_080039222.1\|3912604_3913132_-	hypothetical protein	NA	NA	NA	NA
WP_080039223.1\|3913348_3913951_-	hypothetical protein	A0A218MNI5	uncultured_virus	3.0e-18	31.9
WP_080039224.1\|3915542_3916853_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.5e-09	68.2
WP_155127513.1\|3917091_3918621_-\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	8.8e-06	23.7

DBSCAN-SWA_4

3958977 : 4019805

Streptomyces_phage(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080039253.1\|3958977_3960339_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_080039254.1\|3960418_3961117_+	hypothetical protein	NA	NA	NA	NA
WP_155127540.1\|3961201_3962320_-	NlpC/P60 family protein	A0A1J0GW44	Streptomyces_phage	7.6e-23	38.4
WP_155127543.1\|3962430_3963351_+	hypothetical protein	NA	NA	NA	NA
WP_080039257.1\|3963428_3964058_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_080039258.1\|3964096_3965209_+	hypothetical protein	NA	NA	NA	NA
WP_080039259.1\|3965354_3965747_-	hypothetical protein	NA	NA	NA	NA
WP_080046791.1\|3965872_3966082_-	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_080039260.1\|3966230_3967409_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_080039261.1\|3967485_3967860_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_080039262.1\|3967856_3968807_+	M56 family metallopeptidase	NA	NA	NA	NA
WP_155127546.1\|3968849_3969728_+	hypothetical protein	NA	NA	NA	NA
WP_080039264.1\|3969851_3970121_+	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_080039265.1\|3970191_3971574_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_080039266.1\|3971648_3972215_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_080039267.1\|3972224_3972443_-	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_080039268.1\|3972439_3973027_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_080039269.1\|3973308_3973812_+	DUF2269 domain-containing protein	NA	NA	NA	NA
WP_155127549.1\|3974649_3975936_+	MFS transporter	NA	NA	NA	NA
WP_080039271.1\|3976024_3977446_+	MFS transporter	A0A0M3UL24	Mycobacterium_phage	4.0e-53	34.1
WP_080039272.1\|3977472_3977961_+	universal stress protein	NA	NA	NA	NA
WP_080046792.1\|3978186_3979161_+	hydrolase	B5LJD6	Mycobacterium_phage	2.6e-19	47.5
WP_155127552.1\|3979887_3980493_-	DUF305 domain-containing protein	NA	NA	NA	NA
WP_080039273.1\|3981193_3984244_+	DEAD/DEAH box helicase	Q6J7X8	Actinoplanes_phage	1.8e-10	27.6
WP_155129699.1\|3985539_3985836_-\|transposase	transposase	NA	NA	NA	NA
WP_080039274.1\|3985974_3986598_-	CHAP domain-containing protein	NA	NA	NA	NA
WP_080039275.1\|3987039_3987672_-	CHAP domain-containing protein	A0A2H5BLQ0	Streptomyces_phage	3.4e-12	33.5
WP_155129699.1\|3988250_3988547_+\|transposase	transposase	NA	NA	NA	NA
WP_080039276.1\|3989878_3991441_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_080039277.1\|3991937_3992663_+	hypothetical protein	Q8LTJ6	Lactococcus_phage	4.3e-19	35.0
WP_080039278.1\|3992725_3993184_-	excalibur calcium-binding domain-containing protein	NA	NA	NA	NA
WP_080039279.1\|3993202_3993937_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_080039280.1\|3995279_3995744_-	hypothetical protein	NA	NA	NA	NA
WP_080039281.1\|3995841_3996363_+	universal stress protein	NA	NA	NA	NA
WP_080039282.1\|3996568_3996796_+	DUF2933 domain-containing protein	NA	NA	NA	NA
WP_080039283.1\|3996792_3999510_+	heavy metal translocating P-type ATPase	A0A218MNH6	uncultured_virus	2.4e-83	35.1
WP_080039284.1\|3999764_4000877_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_155129702.1\|4000904_4002041_+	DegT/DnrJ/EryC1/StrS aminotransferase family protein	NA	NA	NA	NA
WP_080039286.1\|4002401_4002827_-	hypothetical protein	NA	NA	NA	NA
WP_155127555.1\|4002814_4003267_-	hypothetical protein	NA	NA	NA	NA
WP_080039288.1\|4003263_4003911_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_080039289.1\|4004302_4005655_+	phenylacetate--CoA ligase family protein	NA	NA	NA	NA
WP_080039290.1\|4005889_4006843_-	M56 family metallopeptidase	NA	NA	NA	NA
WP_080039291.1\|4006839_4007214_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_155127558.1\|4007425_4007596_+	hypothetical protein	NA	NA	NA	NA
WP_080039292.1\|4007898_4010256_+	heavy metal translocating P-type ATPase	A0A218MNH6	uncultured_virus	2.5e-84	32.7
WP_155127561.1\|4010582_4010969_+	hypothetical protein	NA	NA	NA	NA
WP_080039294.1\|4011061_4012621_+	multicopper oxidase family protein	NA	NA	NA	NA
WP_080039295.1\|4013295_4013631_-	hypothetical protein	NA	NA	NA	NA
WP_080039296.1\|4013620_4014445_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_080039297.1\|4014441_4015572_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_080039298.1\|4015568_4016408_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.7e-41	43.4
WP_080039299.1\|4017014_4018124_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_080039300.1\|4018224_4019805_+\|transposase	IS1182 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP017717

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CRISPR-Cas detection and classification

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