CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP020451	Streptococcus salivarius strain FDAARGOS_259 chromosome, complete genome	4 crisprs	csa3,DEDDh,cas3,WYL,DinG	0	3	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP020451_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020451_1

43739-43813

Orphan

Consensus_repeat	Method
GACCTAAAAAGGTCCACTGGAACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020451_1

>merge|NZ_CP020451|1|43739-43813|CRISPRCasFinder
GACCTAAAAAGGTCCACTGGAACTTCCTCGCTTTTTCATTTCTGGGCTCGGACCTAAAAAGGTCCACTGGAACTT

>NZ_CP020451|1|1|43739-43813|CRISPRCasFinder
GACCTAAAAAGGTCCACTGGAACTT	CCTCGCTTTTTCATTTCTGGGCTCG
GACCTAAAAAGGTCCACTGGAACTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020451.2\|WP_004182618.1\|36767_38078_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133045
NZ_CP020451.2\|WP_060971928.1\|48625_49852_-\|voltage-gated-chloride-channel-family-protein	unknown	unknown	gnl\|CDD\|239654
NZ_CP020451.2\|WP_060971929.1\|51791_52235_-\|flavodoxin	unknown	unknown	gnl\|CDD\|180922
NZ_CP020451.2\|WP_004182627.1\|46000_46912_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_CP020451.2\|WP_002883489.1\|48150_48498_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NZ_CP020451.2\|WP_004182626.1\|45466_45976_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|224867
NZ_CP020451.2\|WP_004182617.1\|35655_36759_-\|glycoside-hydrolase-family-47-protein	unknown	unknown	gnl\|CDD\|366548
NZ_CP020451.2\|WP_080611398.1\|38996_40148_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|223458
NZ_CP020451.2\|WP_037600183.1\|52602_52974_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020451.2\|WP_037600186.1\|50206_51742_-\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238504
NZ_CP020451.2\|WP_002883513.1\|46987_47164_+\|DUF3042-family-protein	unknown	unknown	gnl\|CDD\|371431
NZ_CP020451.2\|WP_003097027.1\|33619_33808_-\|DNA-directed-RNA-polymerase-subunit-beta	unknown	unknown	gnl\|CDD\|378713
NZ_CP020451.2\|WP_021144287.1\|49848_50133_-\|chorismate-mutase	unknown	unknown	gnl\|CDD\|168880
NZ_CP020451.2\|WP_004182623.1\|42486_43425_+\|bifunctional-biotin--[acetyl-CoA-carboxylase]-synthetase/biotin-operon-repressor	unknown	unknown	gnl\|CDD\|237010
NZ_CP020451.2\|WP_004182622.1\|41013_42207_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP020451.2\|WP_080611397.1\|38220_39000_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020451.2\|WP_004182625.1\|43814_45467_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_CP020451.2\|WP_004182624.1\|43411_43597_-\|DUF3272-family-protein	unknown	unknown	gnl\|CDD\|314526
NZ_CP020451.2\|WP_064525319.1\|33809_35081_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP020451.2\|WP_004182616.1\|35148_35385_-\|DUF1146-domain-containing-protein	unknown	unknown	gnl\|CDD\|131380

Protein	Function_ID	Function_description	E-value
NZ_CP020451.2\|WP_004182618.1\|36767_38078_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	3.02912e-51
NZ_CP020451.2\|WP_060971928.1\|48625_49852_-\|voltage-gated-chloride-channel-family-protein	gnl\|CDD\|239654	cd03682, ClC_sycA_like, ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation competitiveness, and N2 fixation on Phaseolus vulgaris plants, due to its reduced ability for acid resistance. This family is part of the ClC chloride channel superfamiy. These proteins catalyse the selective flow of Cl- ions across cell membranes and Cl-/H+ exchange transport. These proteins share two characteristics that are apparently inherent to the entire ClC chloride channel superfamily: a unique double-barreled architecture and voltage-dependent gating mechanism. The gating is conferred by the permeating anion itself, acting as the gating charge.	2.44706e-170
NZ_CP020451.2\|WP_060971929.1\|51791_52235_-\|flavodoxin	gnl\|CDD\|180922	PRK07308, PRK07308, flavodoxin; Validated.	4.73963e-83
NZ_CP020451.2\|WP_004182627.1\|46000_46912_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.44567e-134
NZ_CP020451.2\|WP_002883489.1\|48150_48498_-\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	6.42285e-69
NZ_CP020451.2\|WP_004182626.1\|45466_45976_-\|GAF-domain-containing-protein	gnl\|CDD\|224867	COG1956, COG1956, GAF domain-containing protein [Signal transduction mechanisms].	1.17131e-72
NZ_CP020451.2\|WP_004182617.1\|35655_36759_-\|glycoside-hydrolase-family-47-protein	gnl\|CDD\|366548	pfam01270, Glyco_hydro_8, Glycosyl hydrolases family 8.	6.02911e-18
NZ_CP020451.2\|WP_080611398.1\|38996_40148_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	2.70268e-173
NZ_CP020451.2\|WP_037600186.1\|50206_51742_-\|chloride-channel-protein	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	6.95841e-162
NZ_CP020451.2\|WP_002883513.1\|46987_47164_+\|DUF3042-family-protein	gnl\|CDD\|371431	pfam11240, DUF3042, Protein of unknown function (DUF3042). This family of proteins with unknown function appears to be restricted to Firmicutes.	1.01731e-15
NZ_CP020451.2\|WP_003097027.1\|33619_33808_-\|DNA-directed-RNA-polymerase-subunit-beta	gnl\|CDD\|378713	pfam11772, EpuA, DNA-directed RNA polymerase subunit beta. This short 60-residue long bacterial family is the beta subunit of the DNA-directed RNA polymerase, likely to be EC:2.7.7.6. It is membrane-bound and is referred to by the name EpuA.	7.49228e-12
NZ_CP020451.2\|WP_021144287.1\|49848_50133_-\|chorismate-mutase	gnl\|CDD\|168880	PRK07248, PRK07248, chorismate mutase.	7.9578e-40
NZ_CP020451.2\|WP_004182623.1\|42486_43425_+\|bifunctional-biotin--[acetyl-CoA-carboxylase]-synthetase/biotin-operon-repressor	gnl\|CDD\|237010	PRK11886, PRK11886, bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA.	8.9655e-133
NZ_CP020451.2\|WP_004182622.1\|41013_42207_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP020451.2\|WP_004182625.1\|43814_45467_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP020451.2\|WP_004182624.1\|43411_43597_-\|DUF3272-family-protein	gnl\|CDD\|314526	pfam11676, DUF3272, Protein of unknown function (DUF3272). This family of proteins with unknown function appears to be restricted to Streptococcus.	3.72715e-09
NZ_CP020451.2\|WP_064525319.1\|33809_35081_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP020451.2\|WP_004182616.1\|35148_35385_-\|DUF1146-domain-containing-protein	gnl\|CDD\|131380	TIGR02327, conserved_hypothetical_protein, conserved hypothetical integral membrane protein. Members of this protein family are small, typically about 80 residues in length, and are highly hydrophobic. The gene is found so far only in a subset of the Firmicutes in association with genes of the ATP synthase F1 complex or NADH-quinone oxidoreductase. This family includes ywzB from Bacillus subtilis; pfam06612 describes the same family as Protein of unknown function DUF1146.	5.43777e-08

>NZ_CP020451.2|WP_004182624.1|43411_43597_-|DUF3272-family-protein
MIPQILFITLETIFETVCFNYSLQHGYYFFTAFFGYLLFRRLWTTYVVSRIARAADKSTKK
>NZ_CP020451.2|WP_004182623.1|42486_43425_+|bifunctional-biotin--[acetyl-CoA-carboxylase]-synthetase/biotin-operon-repressor
MKTYEHVYDILSKSPDFVTGESLAKSLGVSRTAIWKAIQTLQEQGIDITSVRKKGYYLEKGDILLPQDISKQLNIPVYFNPDSNSTQLDAKHGMEKNNPTPALYLASSQKAAKGRFDRHFFAIPQGGIYMSIHLKPNCHFADLPPYTMMAAAAIVKAIQRLTGINTEIKWVNDIYLNNKKMAGILTEAISSIESGRITDVIIGVGLNFSISDFPKELANKATSLFTSEKPSITRNQLISEIWKLFLTIPTSDLVKVYKEKSLVLDKQVTFEQAGKTYTGVAKEIGDKGQLLVLTDDGQEKWLSAGEVSLTSW
>NZ_CP020451.2|WP_004182622.1|41013_42207_-|methionine-adenosyltransferase
MSERKLFTSESVSEGHPDKIADQISDAILDAILAEDPDAHVAAETAVYTGSVHVFGEVSTTAYVDINRVVRDTIAEIGYNNAEYGFAAESVGVHPSLIEQSPDIAQGVNESLEVRGTGDQDPLDLIGAGDQGLMFGFAIDETPEFMPLPVSLSHKLVKKLADLRKSGEISYLRPDAKSQVTVEYDENDQPVRVDTVVISTQHDPEATNDQIRQDVIEKVIKAVIPAEYLDDETKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVANPVSVRVDTFGTATVAESKLEAAVRDLFDLRPAGIIQMLDLKRPIYRQTAAYGHMGRTDIDLPWEKLDKVEALKEAVNH
>NZ_CP020451.2|WP_080611398.1|38996_40148_-|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MGKLNIMVVFGTRPEAIKMAPLILELKKHQETINTITVVTAQHRQMLDQVLETFEIVPDYDLDIMGKNQSLQEITSKILANFDPVVKKEQPDLVLVHGDTTTTFAAGLVAFYNKVSIGHVEAGLRTYDKYSPYPEEMNRQMTDSLSDLYFAPTQESKANLLSENHKKEAIYVTGNTAIDALKLTVKDNYYHEVLDKIDENKKIILVTMHRRENQGEPMRRVFKTLRHMVDEHSEIEVVYPVHLSPSVQAAAKEILGDHDRIHLIAPLDVFDFHNLASRSYFIMSDSGGVQEEAPSLGKPVLVLRDTTERPEGVKAGTLKLVGTDPDKVKEAMTSLLTEEALYKEMSKAPNPYGDGKASERIVQAIKVYFNLEDSVSEFHEGGN
>NZ_CP020451.2|WP_080611397.1|38220_39000_-|hypothetical-protein
MSVKRDKKIWYWILCLIFFEALLFLYCNQVNPNLFMFEAFFLILGIAAVCFLTEILITWLIILSFALSIFVLVSGVVYLPLNDTLVLIFSFPLLMGILSKIKYYFYKFISSVQIEEVKASNAYRDLLEDKKPVQALLIHWSHEEQFFELSPREYNHLLTSIYHQILDKLDRFEQVFYVSEGSYLILSKNKSRNLEKIYKTSLEEHLKEMTFTRGSSYQGIQFQSGFLVIDKKNSKKFDNYSELMSNLNRQLETDIIVEY
>NZ_CP020451.2|WP_004182618.1|36767_38078_-|glycosyltransferase-family-2-protein
MVSQFLMIFTLISIWISLIWGVVILVSAVHFWLKHSDFKVDKEELPYYPKVTIVVPAHNEDVVISQTAKAILNMNYPHDKVELLLFADNCSDNTYQECLAVQALPEYAGRNITIINRKGTGGKAGVLNDALKMADGEYICIYDADAMPETNALYFLVKEVMKDPERRVASFGRNKTRNAKQNFLTRCINQEIVVTQRVHHVGMWHLFKIGRIPGTNFIIQTEFVKSIGGWRNGALTEDTDISFKIMQSGKLIALAYNSEAFQQEPETLKSYYMQRKRWAKGNYEVVISNFKHLFGKGNWRVKLEVANYSCIFFWFNGAIVLSDLIFFANVLAIVLHIFFPTVQIPFAFDASNIYIAQLMLFNWLLMIGLYLLQINVALASQFGQATSKQIWLAILSYFSYAQLFIIVSLDSLWSIIMDKILHREGTTWVKTKRFAE
>NZ_CP020451.2|WP_004182617.1|35655_36759_-|glycoside-hydrolase-family-47-protein
MKTKYFKYLWFVVILGLFVFSMFTIRMKTKTDIQDRIYQKWEKHFVVKKGNEAYVKTTNDKDKDVVLSESQSYGMLITVRAAKKGLANQKDFERLYKYYLSHRIEGNQLMSWEQIVQKSAKNVDDHNATDGDLYIAYALIEASKQWPSHKDEYQTQAKALLQDILKYNYNENIGILTVGNWANKDSKYYNLMRTSDTVPKQFQAFYEVTKDKKWLDINNKMLSSLETISSKTKTGLIPDFIWVDESGARVVKPYTISNQFDSTYSYNACRLPYNLTQSNDEKSQKVLNKMLDFFMTQKNVFSNYNLSGKFLDDHQAASFKAPIAFAAEKDQKYLKLVQQNKIVFMQDLPVKNYYDSAIITLVAMEFF
>NZ_CP020451.2|WP_004182616.1|35148_35385_-|DUF1146-domain-containing-protein
MTILNDMVPLASHLVFIGLTYQMVNTLFDWEKITKNVIVNTGKLRLFLLFISIAIGFLVSSFFIYVLTLCQSLASSIS
>NZ_CP020451.2|WP_064525319.1|33809_35081_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDKIIVQGGNTRLSGEVVIEGAKNAVLPLLAATILASEGQTTLTNVPILSDVYTMNNVVRGLDIAVDFDEENNTVVVDASGEILDQAPYEYVSKMRASIVVLGPILARNGHAKVSMPGGCTIGSRPIDLHLKGLEAMGAKITQVGGDITATAEKLKGATIYMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLALLLNEMGADVKGAGTESLVIKGVKALHGTKHAVVQDRIEAGTFMVAAAMTSGDVLIKDAIWEHNRPLISKLLEMGVYVKEEDGGIRVKSDVSQLKPVTVKTLPHPGFPTDMQAQFTALMAVVNGESTMIETVFENRFQHLEEMRRMGLHSEILRDTAMIHGGLPLQGAQVMSTDLRASAALILTGMVAEGTTTVGKLTHLDRGYYQFHEKLAKLGANISRVSEA
>NZ_CP020451.2|WP_003097027.1|33619_33808_-|DNA-directed-RNA-polymerase-subunit-beta
METGKGYVFRQLLLVLSVCVIGLAFLAIGLMIGYAVLGEGKDPISILKPETWQAIVAKFTGK
>NZ_CP020451.2|WP_004182625.1|43814_45467_-|DNA-polymerase-III-subunit-gamma/tau
MYQALYRKYRSQTFGEMVGQKVISTTLRQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVDGEPCNHCDICRDITNGSLEDVIEIDAASNNGVDEIREIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHKIPATILSRVQRFEFKSIKQGAIKEHLASILEKEGLTFDDEALTIIARRAEGGMRDALSILDQALSLSPDNHVSQTVAEEITGSIGLTALDSFVANIRNQDTTQALSNLETLFDNGKSMSRFATDLLEYFRDLLIVKAGGENSHHSPLFEENLSLEQDRLFQLIDLVTSALPEIKTGTHPKIYAEMLTIKLSETHSQMSQEIPGNLQEELDSLRREVEGLRKALKEGKVQGEVAPTRKAKPAYQYKVDREKILTIMRETMENPQKSRQCLDALKATWPEILDSISPQNRALLNGSEPVLANQENAILAFNAAFNAEQVMKRSDLNDMFGNIMSSAAGFSPNIMAVPKAEFEKLRTEFARSLKSKEELEKEDREEYIPQELEFLSDVVEIED
>NZ_CP020451.2|WP_004182626.1|45466_45976_-|GAF-domain-containing-protein
MVVMTNEEKKSAYEIMLAQAKAVFANEDNALANFSNASALLNTTLPNSVFTGFYLMDNINNELILGPFQGNVSCVRIDLGKGVCGQSAAENRTLIVEDVTKHANYIACDSAARSEIVVPMVKDGKLVGVLDLDSHQVGDYNDVDQDYLEAFVKILLEKTELTFGMFEVN
>NZ_CP020451.2|WP_004182627.1|46000_46912_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MKTKLIVVAGPTAVGKTALGIKLAQRFNGEIISGDSQQVYRQLNIGTAKATPEEQAAAVHHLIDVRDVDESYSAYDFVTEAEATITDIVSRGKLPIIVGGTGLYLQSLIEGYHLGGQVDQKQVLAYRSELEQLSDQELFDKIDDLGIEIKEINRRRATRALELHRFSENLENTETTYEPFLIGLDDERSLIYDRINTRVDKMVELGLLEEAKWLYDNYPDAQSARGIGYKELFPYFAGNQTLDEALEKLKQNTRRFAKRQLTWFRNRMTVKFYQISSPEYPENVIHDLELFLNEREGEKVGQS
>NZ_CP020451.2|WP_002883513.1|46987_47164_+|DUF3042-family-protein
MAKKHSFAKGVATGVIGTAATVAGAVFAVKKTIIEPEEKKLAFIEENRKKAARRRVSR
>NZ_CP020451.2|WP_002883489.1|48150_48498_-|50S-ribosomal-protein-L19
MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISSGIGVERTFPIHTPRVEKIEVVRYGKVRRAKLYYLRALQGKAARIKEIRK
>NZ_CP020451.2|WP_060971928.1|48625_49852_-|voltage-gated-chloride-channel-family-protein
MKVKQLSDSQGLSYLHLVMLSLYAILLGVLVGLIDAVFGRVLIGLSEYRDQHIFYLVPALPLAGLLIVYLYQKLAGKAAQGMGLIFKVGHNEEDQVPLRLIPLVTVTTWLTHLFGGSAGREGVAVQLGATVSHAFSRYFKIPNASRIFLTMGMAAGFGGLFQTPIAATFFALEVLILGQLSLPILVPTLIASFVASTTSHLLGLEKFSHFVSDSLTINLGTFVKLALLGLVFGLAGNLFAYLLSVAKKKVASLLPNPYYRVLLGSVVLTCLLLILWKGRYTGLGTNLIALSVGGGTIYPLDWLLKLLLTVFTLSLGFQGGEVTPLFAIGASLGAVLAPVLGFPIPLVAGLGYLSVFGSSTNTLLAPIFIGVEVFGPANAVPYAIVMSFAYLINHKTSIYGQQKMLEMQ
>NZ_CP020451.2|WP_021144287.1|49848_50133_-|chorismate-mutase
MDLNEIRQQIDTVDNEIVALLEERMKLVTRVSAYKQRTGKAIYDPEREQALLDKVGASVLNPEYKEAIVASFADIMKRSRIYQASKLEKSRYLE
>NZ_CP020451.2|WP_037600186.1|50206_51742_-|chloride-channel-protein
MNEIERDFRTQSQHLLWSVWRGLLVGGTAGAVVSLFRWLIAKGAAFSVAIYKDALHNPLLILGIVLVNLLIALFIGYLIKQEKDIKGSGIPHVEGELMGLLHPSWWSVLWRKFLGGVLGISMGLMLGREGPSIQLGAMTAKGLAESLKLSAREKRVLIAAGAAAGLSAAFNAPIAGLLFVVEEVYHHFSRHVWVTALTASLVANAVSLRIFGQVPVLAMTEKLPVFPLKDYWILIVLGIFLGVLGYGYEWVVLRIGKVYQGLGKIFHLPSHFHGLLAVLFIIPIGLYFPYLLGGGNELILALNGLHPALTVAILYLAIRFIWSMLSFGSGFPGGIFLPILTLGALSGSVFAAAFENLGFLQVSQFPIFIILGMAGYFGAVSKAPLTAMILVTEMVGDLHQLMTIGVVTLIAYLVMDFMGGEPVYEAMLHNLIAHEPKQVDNIPTMIDLPVTDSLAGRLVKDLTLPDGVLISTQIFQDQSEVVHGDTRLKAGATLYLVVNESNISQVRKLFL
>NZ_CP020451.2|WP_060971929.1|51791_52235_-|flavodoxin
MALAKIVYASMTGNTEEIADIVAKKLEELGHTVDVDECTTVDAADFEDADVCIVATYTYGDGELPDEIVDFYEDLADLDLSGKIFGVVGSGDTFYDYFCHSVDEFENQFTFTGATKGADSVKVDLSAEDEDIENLEVFAEKISEALA
>NZ_CP020451.2|WP_037600183.1|52602_52974_-|hypothetical-protein
MRYLKRLARRYPMQTFLFLFNAGVFTWLQTTGTMIANRLGLSGDGIWIYIPTWVKTLTSHSIESIQTLYSASGWSWLITSMLLTWLLTFLRGLMRAVIIILLVGVGLWLVYRHFELLQNLKLS

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Crispr_ID: NZ_CP020451_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020451_2

212104-212341

Orphan

Consensus_repeat	Method
GAGACCACTTCACTATTTGATGCTTCGGAAACTGGAGTGCTTGATCCTGC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP020451_2

>merge|NZ_CP020451|2|212104-212341|PILER-CR
CTTCACTCTTTGGTGTTTCGGAAACTACTTCACTATTAGATACTTCGGAAACTGGGGTGCTTGATTCTGCTTCACTCTTTAGTGACTCAGAAACTGAAGTCTCAGAGACCACTTCACTGTTTGATGCTTCGGAAACTGGAGTGCTTGATCCTGCTTCACTCTTTGGTGTTTCTGATGCTGAAGTCTCGGATACCACTTCACTAGTTGATGCTTCGGAAACTGGGGTGCTTGATTCTGC

>NZ_CP020451|2|1|212104-212341|PILER-CR
CTTCACTCTTTGGTGTTTCGGAAACTACTTCACTATTAGATACTTCGGAA	ACTGGGGTGCTTGATTCTGCTTCACTCTTTAGTGACTCAGAAACTGAAGTCTCAGAGACCACTTCACTGTTTGATGCT
TCGGAAACTGGAGTGCTTGATCCTGCTTCACTCTTTGGTGTTTCTGATGC	TGAAGTCTCGGATACCACTTCACTAGTTGATGCT
TCGGAAACTGGGGTGCTTGATTCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020451.2\|WP_080611428.1\|220039_221197_-\|DUF2974-domain-containing-protein	unknown	unknown	gnl\|CDD\|371412
NZ_CP020451.2\|WP_002884070.1\|209553_210114_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|224618
NZ_CP020451.2\|WP_049545961.1\|204219_204615_-\|DUF4430-domain-containing-protein	unknown	unknown	gnl\|CDD\|379618
NZ_CP020451.2\|WP_037597654.1\|204611_205085_-\|membrane-protein	unknown	unknown	unknown
NZ_CP020451.2\|WP_073950175.1\|218348_218651_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NZ_CP020451.2\|WP_073950171.1\|219243_220008_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187604
NZ_CP020451.2\|WP_002890638.1\|208652_209552_-\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|235318
NZ_CP020451.2\|WP_064523419.1\|215090_215990_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP020451.2\|WP_073950173.1\|218652_219006_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|227024
NZ_CP020451.2\|WP_073689706.1\|201223_204046_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NZ_CP020451.2\|WP_080610400.1\|221306_221933_+\|Pr6Pr-family-membrane-protein	unknown	unknown	unknown
NZ_CP020451.2\|WP_080611429.1\|221969_222812_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP020451.2\|WP_070846935.1\|217857_218187_-\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|212144
NZ_CP020451.2\|WP_021152048.1\|205374_206103_+\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NZ_CP020451.2\|WP_073950179.1\|216153_217848_-\|DUF2075-domain-containing-protein	unknown	unknown	gnl\|CDD\|378274
NZ_CP020451.2\|WP_049545960.1\|206951_207875_+\|metal-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238557
NZ_CP020451.2\|WP_080611427.1\|207954_208602_+\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_CP020451.2\|WP_080611232.1\|222963_223353_+\|sodium-transporter	unknown	unknown	unknown
NZ_CP020451.2\|WP_060972754.1\|210259_211261_-\|DNA/RNA-non-specific-endonuclease	unknown	unknown	gnl\|CDD\|372824
NZ_CP020451.2\|WP_002884063.1\|206092_206932_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224033

Protein	Function_ID	Function_description	E-value
NZ_CP020451.2\|WP_080611428.1\|220039_221197_-\|DUF2974-domain-containing-protein	gnl\|CDD\|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	5.61494e-78
NZ_CP020451.2\|WP_002884070.1\|209553_210114_-\|LemA-family-protein	gnl\|CDD\|224618	COG1704, LemA, Uncharacterized conserved protein [Function unknown].	2.30735e-82
NZ_CP020451.2\|WP_049545961.1\|204219_204615_-\|DUF4430-domain-containing-protein	gnl\|CDD\|379618	pfam14478, DUF4430, Domain of unknown function (DUF4430). Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.	3.71688e-19
NZ_CP020451.2\|WP_073950171.1\|219243_220008_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.299e-130
NZ_CP020451.2\|WP_073950175.1\|218348_218651_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	2.54764e-10
NZ_CP020451.2\|WP_002890638.1\|208652_209552_-\|zinc-metalloprotease-HtpX	gnl\|CDD\|235318	PRK04897, PRK04897, heat shock protein HtpX; Provisional.	0
NZ_CP020451.2\|WP_064523419.1\|215090_215990_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	9.07436e-22
NZ_CP020451.2\|WP_073950173.1\|218652_219006_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|227024	COG4679, COG4679, Phage-related protein [Function unknown].	1.63215e-24
NZ_CP020451.2\|WP_073689706.1\|201223_204046_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_CP020451.2\|WP_080611429.1\|221969_222812_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	1.83168e-61
NZ_CP020451.2\|WP_070846935.1\|217857_218187_-\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|212144	cd11537, NTP-PPase_RS21-C6_like, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs. RS21-C6 proteins, highly expressed in all vertebrate genomes and green plants, act as house-cleaning enzymes, removing 5-methyl dCTP (m5dCTP) in order to prevent gene silencing. They show significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, RS21-C6 contains a single MazG-like domain and functions as a tetramer (a dimer of dimers) with a typical four-helical bundle. Divalent ions, such as Mg2+, are required for its pyrophosphatase activity. This family also includes a pyrophosphatase from Archaeoglobus fulgidus (Af1178). Although its biological role remains unclear, Af1178 shows significant sequence similarity to the mouse RS21-C6 protein.	1.11905e-32
NZ_CP020451.2\|WP_021152048.1\|205374_206103_+\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	2.99321e-114
NZ_CP020451.2\|WP_049545960.1\|206951_207875_+\|metal-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238557	cd01137, PsaA, Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.58691e-149
NZ_CP020451.2\|WP_073950179.1\|216153_217848_-\|DUF2075-domain-containing-protein	gnl\|CDD\|378274	pfam09848, DUF2075, Uncharacterized conserved protein (DUF2075). This domain, found in various prokaryotic proteins (including putative ATP/GTP binding proteins), has no known function.	2.81804e-105
NZ_CP020451.2\|WP_080611427.1\|207954_208602_+\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	4.15379e-48
NZ_CP020451.2\|WP_060972754.1\|210259_211261_-\|DNA/RNA-non-specific-endonuclease	gnl\|CDD\|372824	pfam13930, Endonuclea_NS_2, DNA/RNA non-specific endonuclease.	1.00333e-23
NZ_CP020451.2\|WP_002884063.1\|206092_206932_+\|metal-ABC-transporter-permease	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	2.30471e-66

>NZ_CP020451.2|WP_060972754.1|210259_211261_-|DNA/RNA-non-specific-endonuclease
MKEKRNSRIRLFALLVLVFTLGFGFSVDTSKQSLTVSSQVAQADENNGILAFNGQKQFVMEEKDQLGRAHSAHIQLQDKDEPKNKRPGKIKYDPVGWHNYKFYYGDGKSKSWLMNRGHLIGYQFSGVNDEGKNLVPMTAWLNSGNYKGTDEGNQSGMLYYENRLDNWLALHPNYWLDYKVTAIYSGDELLPRQVELQYVGIDSSGNLLEIKLGGDKETLDSQGVTHVVLDNQSPNAEINYADGTATNTVTEFTEAPSEPSSESSQVTEQPSSEPEPVQPIQEENRTVYVARHGTADVYWYDINSMPSNTNKANVVTMTEADALAQGKRHTSKE
>NZ_CP020451.2|WP_002884070.1|209553_210114_-|LemA-family-protein
MIWIIIAIIVVLVIFVIASYNGLVKSRMQTKEAWSQIDVQLKRRNDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMRASDELTRQVSGIFAVAESYPDLKASANFSQLQEELTNTENKIAYSRQLYNSVTSNYNVKLETFPSNVIAKMFSFKAAEFLETPEEEKAVPKVDFSGLGN
>NZ_CP020451.2|WP_002890638.1|208652_209552_-|zinc-metalloprotease-HtpX
MLFDQIARNKRKTWLLLLVFFLLLGLVGYGVGYLWLGSGFGGLILALVIGFIYAVTMIFQSTNVVMAMNGAREVDEQTAPNLYHVVEDMAMVAQIPMPRVFIVDDPSMNAFATGSSPKNAAVAATTGLLAVMNREELEGVIGHEVSHIRNYDIRISTIAVALASAITMLAGMARNMMFWGGGRRRNDDDRNGSSGLEIILLIISLIAIILAPLAATLVQLAISRQREFLADASSVELTRNPQGMINALLKLDNSAPMQHHVDDASAALFINDPKKESGLQKLFYTHPPISERVERLKQM
>NZ_CP020451.2|WP_080611427.1|207954_208602_+|metal-dependent-transcriptional-regulator
MTPNKEDYLKCIYEIGTEEGKISNKEIANRMQVSPPAVTEMIKKLISEDLIIKDKAKGYLLTETGTINIAELYRKHRLIEVFLVDHLQYTCDQIHQEAEILEHTVSDHFIDALDRLLNYPQTCPHGGQIPKSGQLIQEIYDQTFTQDLAPGEYILRRVQDQIDLLHYLKTVGLKIGTPFTFEGFDPFTQLYRLHIDGRDIQIPEAIAGNLYIEAN
>NZ_CP020451.2|WP_049545960.1|206951_207875_+|metal-ABC-transporter-substrate-binding-protein
MKKILSTIALLLLAVVALAACSNKQGSSNKLRVVTTNSIIADITKNIAGDKITLHSIVPVGKDPHEYEPLPDDVKKTSQADLIFYNGINLETGGNAWFTKLVKNAHKTENKDYFAVSDGVKVIYLEGQSEKGKEDPHAWLNLENGIIYAQNIAKQLIAKDPKNKTYYEKNLKSYTDKLSKLDQEAKETFNKIPDEKKLIVTSEGCFKYFSKAYGVPSAYIWEINTEEEGTPDQIKTLVEKLRQTKVPALFVESSVDERPMKTVSKDTNIPIYAKIFTDSIAEKGQDGDSYYNMMKYNLDKITQGLNQ
>NZ_CP020451.2|WP_002884063.1|206092_206932_+|metal-ABC-transporter-permease
MISEFIDGLLNFHFLQNALITALVIGIVGGAVGCFIILRGMSLMGDAISHAVLPGVAISFILGINFFIGAIIFGLLASTMITYIKSNSIIKSDTAIGITFSSFLALGIILIGVANSSTDLFHILFGNILAVQDMDMWITIIVSLLVLATITIFFRPLLLTSFDPILAKSMGVKVTFYHYLLMVILTLVSVTAMQSVGTILIVALLITPAATAYLYVHSLKTMILLSSGLGALASVLGLFIGYSFNIAAGSSIVLTSALLFLISFFIAPKQSGMNKTSKQ
>NZ_CP020451.2|WP_021152048.1|205374_206103_+|metal-ABC-transporter-ATP-binding-protein
MIQIENINVSYQQTLALDNITLNLEGPSITGIIGPNGAGKSTLIKALIGIIPHSGKILFNKQPIRQQLNRISYVAQKADIDFNFPITVRECISLGLYPKTKFFKRLSKSDWSKVTDALTLLGLNDLAHRQISQLSGGQFQRVLIARCLVQEADIILLDEPFVGIDSVSEDIIMNTLRELRDKGKLILIVHHDLSKVPHYFDQVILLNRKLIASGPTNLVFNEDNLRKTYGNSLFYKGDANDF
>NZ_CP020451.2|WP_037597654.1|204611_205085_-|membrane-protein
MKLTIQRMARIAILSALAVGLRSAFIGLPNIQPITAMFFVAVLYLGLVDGLLIMALTMAISGFIFGFGPWVFNQILAFGVLMALWSLIAPRLSLVWQIALVTLLSFLYGVLMDYSYGLLFKSGLTFVISGLLYDTYHAVSTLLFYPFIQSIFRRFLK
>NZ_CP020451.2|WP_049545961.1|204219_204615_-|DUF4430-domain-containing-protein
MKKIATYIFLALSLVTLAACGKNEAAKLTSSTNNHQSKVQGQVTLILKTDKESKKKSVEIQKGDTVLDVLEEVYPVQENDGFITEIDGISQDKDKGIYWMFDVNGKLGEKAANQLKVEDGDEIKFYQEKYN
>NZ_CP020451.2|WP_073689706.1|201223_204046_-|phosphoenolpyruvate-carboxylase
MAFNKLESSNNQEIISEEVGILKELLDDATRGMAGEQGLTTIQHLVELYDEGDYVALTQAISEMTNDDMVVASRYFSLLPLLINISEDVDLAYEVNHKNNIDESYLGKLSETFDVVAESENARDILEHVNVVPVLTAHPTQVQRKTMLELTNHIHELLRKHRDVKAGLINKDKWYADLRRYVEIMMQTDIIREKKLKVKNEITNVMEYYNSSLIKAITNLSHEFKRLAVEKGIELDNPTPITMGMWIGGDRDGNPFVTAETLKLSATVQSEVILNYYIEKVDNLYRSFSLSSRLTEVSDTVAEMAKHSPDTSVYRENEPYRRAFSYIQSKLIQTLLFFKEGNFSKERVAKRLSENVRLGSASTGEVVADYVQQRLSQSLQAVSQQTTEFYETAEDFHDDLLAIKNSLLENDDAVLISGDFEELLQAVEVFGFYLATIDMRQDSSVHETCVAELLKSANIVDNYSELTEVEKVAVLLKELQEDPRTLSSTNVPKSEILEKELAIFRTARLLKDYIGEDVIKQHIISHTESVSDMFELAILLKEVGLVDTERARVQIVPLFETIEDLENSNDIMKQYLGYDIVKRWIKNSNNYQEIMLGYSDSNKDGGYLSSGWTLYKAQNELTKIGEERGIKITFFHGRGGTVGRGGGPSYDAITSQPFGTIKDRIRLTEQGEVIGNKYGNKDAAYYNLEMLVSAALDRMVTRQIADPEELVDFREVMDGIVHDSNVIYRDLVFGNEHFYDYFFEASPIKEVSSLNIGSRPAARKTITEISGLRAIPWVFSWSQNRIMFPGWYGVGSAFNRFIQAEEGNLEKLQHMFETWPFFRSLLSNVDMVLSKSDMNIAFHYAQLAESEEVRSVFNIILDEWQLTKDVILAIEKHDGFLDESPSLKASLDFRLPYFNVLNYIQIELIKRLRNNDLTDDEISLIHITINGIATGLRNSG
>NZ_CP020451.2|WP_064523419.1|215090_215990_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MEKRHKHVSPTLDIMAKKIFSLPEVTVAFIRDILDLDVVDAQILEGTQLHKKDFDEDELFSTSVDVRAKLNDGTEVIIEIQVRKQHYFLNRFHYYLANQLVENVQQLRQQGQTHKMYEQMEPVYGIAILEKTLLPDEESPINTYWMANSRTGNPLNSYYKDGKRQNLLQIAFLELDKYNKGKHITDEGRQWLEFFGNLPFSKEPSQAVTHADSLLDSSSWTQEEKAMIDERIRIQENYDMTMETAIDEAHEEGLEQGLERGRHEGQLELIRKMLSKGLSLEVVSDVTGLSVEELETLLS
>NZ_CP020451.2|WP_073950179.1|216153_217848_-|DUF2075-domain-containing-protein
MDIELYFEDKSFIEQNFELKEFNLISTSYIKDYPILYILYRDKSEAYIGQTTNARNRMKNHLKNPVRRKLKRVLLIGHDKFNQSATYNIETNLINYFLADGIFKLQNKSQVSSNQVIHNYYQKQYYNEEVFQKLWDKLRQKGLARNSSDVIQNKDVYKLSPFHQLSDSQYGVKEQIIDYCRRNLKKLKEGEHKVFLVKGEAGTGKSVVLSSLYNDLCNLSSDKDEGDKESGLYKTVNRLLVNHSEVLKTYQTMSKSLPNMKKKDIMKPTSFINSVDKEKITKSDITLVDEAHLLLTSRDAYNGFHYENQLEEIIKRSKITIVIFDPKQVLKLKSYWDEQTMDSIMSKYDTETLYLKEQFRMNASDEIIEWIDNFVEKTILPLPKPTETFDFQICKSSQELFDKITELNKKDNLSRLVATFDFTHKKDGEEYYVDEEGINLPWNLATKGVWAEDPETLKQVGSIYTVQGFDLNNVGVILGPSVSLDEETNSIKILQHKYKDKGAFQIPQEFEKNFSKENADSYKEEIVLNSINILMKRAIKGLYIYAIDSKLNDYLLKLKRDMKL
>NZ_CP020451.2|WP_070846935.1|217857_218187_-|nucleotide-pyrophosphohydrolase
MKELMNKINQFRDDRDWRKFHNEKDLAISISLEASELLELFQWKKSEEVVASSLKEIKEELADVLIYSLMMADNLNLDVEDIIKSKLDLNEQKYPVEKSRGSNKKYNEL
>NZ_CP020451.2|WP_073950175.1|218348_218651_-|helix-turn-helix-transcriptional-regulator
MVREKNPAIGSSWDDLQKTIFTKEEIAASELRVALMLEIIDARKKQGISQKKLEELSGVKQPVIARMETGKTAPQLDTVLKILASLGKTLAVVPLDSHVK
>NZ_CP020451.2|WP_073950173.1|218652_219006_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MYPIHFYKDRNGHEPVREYIETLYINSSKDSRIKLHKIQDYLTMLKNRGTMIGEPFIKHLEGDIWELRPLRDRILFAAWLDDGFILLHHFVKKTRKTPRRELMKAQKALDDIRKRGL
>NZ_CP020451.2|WP_073950171.1|219243_220008_-|SDR-family-NAD(P)-dependent-oxidoreductase
MPKNVLITGATSGIGEATVRAFAKEGENLILTGRRVERLQALKEELQAIYPDQKVWTFALDVTDMDMVKDVCQAILKSVGQVHVLVNNAGLALGLTAYQDYEEWDLLTMLDTNVKGLMMVTRQILPSMVAANEGHIINMGSTAGIYAYAGAAVYSATKAAVKTFSDGLRIDTIATDIKVTTIQPGIVETDFSQVRFHGDKDKAAKVYQGLEALQAQDIAEAVLYVTKQPRRVQISDMTIMANQQATGFTIHRGE
>NZ_CP020451.2|WP_080611428.1|220039_221197_-|DUF2974-domain-containing-protein
MSHLIDYLDKVKDLPFDQEPLNILDKVCINEIGYLTYEKWLSASDLKETINLHDYAEGKELNPEYTFMVTKERVDLAEAMVRSKRFAGLNLSDYCSVLDKEVEKQFAAMIFSLPELDYQQIVFRGTDDSVIGWKEDFQLTYSREIPAHRSAIAFLSEHLPKLSGYIAVSGHSKGGNLALYSAVQGSTALREQIAELLLLDSPGLMKSLLEKPSYQELKARMTVIRPQDSVVGVMLYWDRPAQLVAAEGIGFAQHNALTWEVDLVANDFVYEDQPTELSQRLEETFQEWIETLPNQELKQVCDLFFDTILDSGIESLDDISIKTLPKLGQLLQEFGNLTDQQKKVLQDGFNQLLSIFWKSGDKKSSLPKLELPDFIKKLGELTNND
>NZ_CP020451.2|WP_080610400.1|221306_221933_+|Pr6Pr-family-membrane-protein
MAISRFYRILLALCGLVGVSIQIHDDGWGMLLYYTVLSNILVFSSLIFFIIYDFKKGDATTNTQLLRYKGGVTMAILITGVIYHILLAPITEPEKFWTLRNFLVHYIVPWGLVLDTLIFDAKKAYRLREPIYWSVVPLSYFAFALLNGLVLKLPIPGAKDSPFAYFFINVNKFGWNKVLVNVLVISAGYIAVGYLLYLLKKFIGRKPA
>NZ_CP020451.2|WP_080611429.1|221969_222812_-|Cof-type-HAD-IIB-family-hydrolase
MSKLIFLDVDGTLVDYHNRIPESAIKAIRQAREKGHLVYVCTGRSKAEMQPELWEIGLDGMIGGNGSYVEHHGQVLMHQLISKEDAAKIVDWLTERHLAFYLESNNGLFASPDFRERARETLKTYAIQKGQSAESVEGKEPEDFIHGLQYGGELYRDDLNKVSFVLDSYQDHLDSKEAFPQLEAHTWGGRGETALFGDLGVKYINKSHAIDVLLEHLGAKRSDTIAFGDAKIDIPMLEYCEVGVAMGNGDPEILAMADLVTDDVEADGLYKAFDKLGLLQ
>NZ_CP020451.2|WP_080611232.1|222963_223353_+|sodium-transporter
MNDLKTLLNHLPYKLAAYDAQGNFLYDNGGADGSFFPREDENLPDWIMSEVLASPTKERSYQIPTDSFDQVLIQTYQAAIDNEGKVLGFWETIYDLKQPLKTYLDNSAQALVAWSDATSGASFKEETDF

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Crispr_ID: NZ_CP020451_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020451_3

771234-771334

Orphan

Consensus_repeat	Method
AAAAATTGGTATAGTCTGATTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020451_3

>merge|NZ_CP020451|3|771234-771334|CRISPRCasFinder
AAAAATTGGTATAGTCTGATTTTTATTTACAAAACCAACAATGATAGTTTACAACAAGTAATAATAGTTGTCAAATAGAAAAATTGGTATAGTCTGATTAT

>NZ_CP020451|3|2|771234-771334|CRISPRCasFinder
AAAAATTGGTATAGTCTGATTTT	TATTTACAAAACCAACAATGATAGTTTACAACAAGTAATAATAGTTGTCAAATAG
AAAAATTGGTATAGTCTGATTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020451.2\|WP_073687441.1\|775193_777380_-\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|131058
NZ_CP020451.2\|WP_080611582.1\|758406_759156_-\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|184840
NZ_CP020451.2\|WP_080611585.1\|762342_763215_-\|Rgg/GadR/MutR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273772
NZ_CP020451.2\|WP_080611584.1\|760611_762189_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP020451.2\|WP_080611593.1\|777534_778473_-\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|273356
NZ_CP020451.2\|WP_049545128.1\|759739_760456_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NZ_CP020451.2\|WP_002886451.1\|774280_775096_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197313
NZ_CP020451.2\|WP_080611587.1\|764988_765426_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NZ_CP020451.2\|WP_002883613.1\|779441_780149_-\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NZ_CP020451.2\|WP_080611589.1\|767415_769185_-\|PTS-mannitol-transporter-subunit-IICBA	unknown	unknown	gnl\|CDD\|225123
NZ_CP020451.2\|WP_080611595.1\|780150_780594_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP020451.2\|WP_080611586.1\|763833_764979_-\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP020451.2\|WP_070576224.1\|781728_782595_-\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_CP020451.2\|WP_080611590.1\|769371_771186_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP020451.2\|WP_080611596.1\|780758_781736_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_CP020451.2\|WP_080611592.1\|772827_774177_-\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NZ_CP020451.2\|WP_080611591.1\|771498_772755_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NZ_CP020451.2\|WP_038675203.1\|778636_779449_-\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|334323
NZ_CP020451.2\|WP_080611588.1\|765415_767380_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|226234
NZ_CP020451.2\|WP_080611583.1\|759284_759614_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235822

Protein	Function_ID	Function_description	E-value
NZ_CP020451.2\|WP_073687441.1\|775193_777380_-\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|131058	TIGR02003, PTS_system_glucose-specific_IIBC_component, PTS system, IIBC component. This model represents a family of fused B and C components of PTS enzyme II. This clade is a member of a larger family which contains enzyme II's specific for a variety of sugars including glucose (TIGR02002) and N-acetylglucosamine (TIGR01998). None of the members of this clade have been experimentally characterized. This clade includes sequences from Streptococcus and Enterococcus which also include a C-terminal A domain as well as Bacillus and Clostridium which do not. In nearly all cases, these species also contain an authentic glucose-specific PTS transporter. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP020451.2\|WP_080611582.1\|758406_759156_-\|isoprenyl-transferase	gnl\|CDD\|184840	PRK14830, PRK14830, undecaprenyl pyrophosphate synthase; Provisional.	3.20398e-177
NZ_CP020451.2\|WP_080611585.1\|762342_763215_-\|Rgg/GadR/MutR-family-transcriptional-regulator	gnl\|CDD\|273772	TIGR01716, HTH-type_transcriptional_regulator_rgg, transcriptional activator, Rgg/GadR/MutR family, C-terminal domain. This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions].	3.09233e-23
NZ_CP020451.2\|WP_080611584.1\|760611_762189_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.05161e-68
NZ_CP020451.2\|WP_080611593.1\|777534_778473_-\|AEC-family-transporter	gnl\|CDD\|273356	TIGR00946, Uncharacterized_transporter_MTH_1382, he Auxin Efflux Carrier (AEC) Family. [Transport and binding proteins, Other].	7.14663e-35
NZ_CP020451.2\|WP_049545128.1\|759739_760456_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	2.99288e-137
NZ_CP020451.2\|WP_002886451.1\|774280_775096_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197313	cd09079, RgfB-like, Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins. This family includes Streptococcus agalactiae RgfB (for regulator of fibrinogen binding) and related proteins. The function of RgfB is unknown. It is part of a putative two component signal transduction system designated rgfBDAC (the rgf locus was identified in a screen for mutants of Streptococcus agalactiae with altered binding to fibrinogen). RgfA,-C,and -D do not belong to this superfamily: rgfA encodes a putative response regulator, and rgfC, a putative histidine kinase. All four genes are co-transcribed, and may be involved in regulating expression of bacterial cell surface components. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	5.47787e-99
NZ_CP020451.2\|WP_080611587.1\|764988_765426_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	1.38628e-59
NZ_CP020451.2\|WP_002883613.1\|779441_780149_-\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	1.49987e-106
NZ_CP020451.2\|WP_080611589.1\|767415_769185_-\|PTS-mannitol-transporter-subunit-IICBA	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP020451.2\|WP_080611595.1\|780150_780594_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.31668e-15
NZ_CP020451.2\|WP_080611586.1\|763833_764979_-\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP020451.2\|WP_070576224.1\|781728_782595_-\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	5.54747e-149
NZ_CP020451.2\|WP_080611590.1\|769371_771186_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP020451.2\|WP_080611596.1\|780758_781736_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	9.80373e-118
NZ_CP020451.2\|WP_080611592.1\|772827_774177_-\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NZ_CP020451.2\|WP_080611591.1\|771498_772755_+\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.74981e-85
NZ_CP020451.2\|WP_038675203.1\|778636_779449_-\|metal-ABC-transporter-permease	gnl\|CDD\|334323	pfam00950, ABC-3, ABC 3 transport family.	2.90165e-62
NZ_CP020451.2\|WP_080611588.1\|765415_767380_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.07433e-23
NZ_CP020451.2\|WP_080611583.1\|759284_759614_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235822	PRK06531, yajC, preprotein translocase subunit YajC; Validated.	3.84081e-19

>NZ_CP020451.2|WP_080611590.1|769371_771186_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGVVGNTNATEILIQGLEKLEYRGYDSAGIFVIDEGKKGHLVKSVGRIADLQAKIDSEVVGSTGIGHTRWATHGQATEANAHPHTSANGRLILVHNGVIENYLQIKDEYLSGDTFKGETDTEIAVHLIGHFVDEGNSVLDAFKKALHIIQGSYAFALVDSENPDTIYVAKNKSPLLIGIGNGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDSVTVSDYDGNLKERNTYTAELDLSDIGRGTYPYYMLKEIDEQPTVMRKLISTYSDENGKLKVDPAIVKTVQESDRIYILAAGTSYNAGFAAKNMIERLTDTPVELGVASEWGYNMPLLSKKPMFILLTQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREATYTMLLHAGPEIAVASTKAYTAQIAALAFLSKAVGEANGKKEAIEFDLVHELSIVAQSIEATLSEKEAISEKVEKLLAATRNAFYIGRGNDYYVAMEASLKLKEISYIQCEGFAAGELKHGTISLIEDGTPVIALISSSSVVASHTRGNIQEVVARGANALTIVEEELAKEGDDIIVNQVHPFLAPISMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
>NZ_CP020451.2|WP_080611589.1|767415_769185_-|PTS-mannitol-transporter-subunit-IICBA
MENSSSFKVRLQKLGTSLSNMVMPNIPALIAWGVLTALVIPDGYIPNEQLATMVSPMLKYVIPLMIGFTGGYNVYSHRGGIVGAIAAFGAIAGSDVTMIIGAMVMGPLAAWLMKKFDQNVQPKIRPGFEMLVNNFSAGFIAFGLMILSFYGIGPVVANLTGLVGQGVDVLVKLSLLPLANIIIEPAKILFLNNALNHGIFTPIGTQQVTEAGKSILFLLEANPGPGLGILLAYALFGRGSAKSSSWGAMIIHFLGGIHEIYFPYVMMKPAMFLAVIAGGVSGTFTFQLLGAGLTAPASPGSIIAIMGMSPKGWGPHLVVLAGVLVATLVSFIVGALVLRFDNSEEASLEEAKAASTAAKAQSKGKVIDKTSESEEISTDSVKRIIFACDAGMGSSAMGASLLRNKIKKAGLDNIPVTNQAISTLDDTDYTLIVTQEELADRAKQRTPRAIHVAVDNFLTSPKYDDIVSQLLNKEQNNVKLKSEDNNSESPNVDLDNIDEVVFAYGVNQGSATMGCETLKTIFRVNNINIPVVTVSNANLSDHSSPNILIVTTIPNQTEVQAIAPNSQLLVVDSLVTTPEYDKIVARMNK
>NZ_CP020451.2|WP_080611588.1|765415_767380_-|PTS-sugar-transporter-subunit-IIA
MIFTNREEKLVDAFLELGSLSLKEMSDILQVSSRTVYRTLSDLMLTLKTENIHVVKKGKQYYLEGDLTPLKNANDSTTIISNRLLGITYDLLNSSKPLINEELQRKYQVSNVTIIQSISQIEERLKDFKLDIVRNRGYLIEGTIWEKRKVLAILLTNAISTQDFNNDQYNLFECLNKDILNHCKISFDKEKSNLGDLDPKIRQYLIILLALADNTLPTNLVGSVSRKALGISQSIFTNLSKLVSSKLYGLQEVLFFASILDETDLMRQETPLFQERFDGDFYYSVSQLIDMVSRLTKIEFFRDKQLFHFLFQHLKLSLAVPILFPEFSRNHVAYLATQNNTYLHNVVSLVVKDIFPNYIQNDYEYSLLTLHFASSLRRSPDIYPISMLLVTDERPLVRSVLVSKIKSAAPFVGDIRVISTSQLKDHDTEDYDYCLSTKHISQYQMDIISIFPSTKEIIELQERLQDVQLNRTIRQRKRDVEIKKYDIQTYLSASTHLLRNFKLISYSNPKEFTEMVNTLVNYLDNVSEKSYLAAKLVSRFDESPMAIPKTNLLLLHTQSHAIVESQFLVVQLDKPVLSKSMNHELEEVHRVLVMLTKINESDEVRDLMTAISQSIIENNLYTEIYKTGNREILYQLLNTIFNERIKKLEEKNEI
>NZ_CP020451.2|WP_080611587.1|764988_765426_-|PTS-sugar-transporter-subunit-IIA
MKFEKNLIKLNQSFDSKEEAIRYCGRQLFEAGHVNESYIDAMIQRDRELSVYMGNFIAIPHGTDSAKNEVKSSGITIVQVPSGVNFGDDENPKVATVLFGIAGLGNEHLEIIQKISIFCADVDNVVKIADAQSVEQIIQLLSSVE
>NZ_CP020451.2|WP_080611586.1|763833_764979_-|mannitol-1-phosphate-5-dehydrogenase
MKRAVHFGAGNIGRGFIGELLFENDFEITFVDVNEEIINALNDRGSYEIEIAEEGQRKIKVSNVLGINNAKDPELVIDAISKADLVTTAIGPNILPYIAELVAKGIMERQASGNKEPLDILACENMIGGSQFLYEEVKKYLTPEGIEFTKELIGFPNAAVDRIVPAQHHEDPLFVIVEPFNEWVVETSRMKNPDLRLEGVHYEKNLEPFIERKLFSVNSGHATSAYTGAHFGAKTILEALQNPTVKTKVESVLTEIRNLLIAKWGFDEEALADYHRVILSRFENPFIVDDVKRVARTPIRKLGYDERFIRPIRELRERDLSYSNLLQTVAYVFSYRDEDDPQSVELQRMLENQELTDVVKEVTGVTDKVLVEEIVSAVEKN
>NZ_CP020451.2|WP_080611585.1|762342_763215_-|Rgg/GadR/MutR-family-transcriptional-regulator
MIGPVEMGALLKKIRLSKNLTLKELASDYLSVSFLSKFERGESDISLSRFFLLLDKLDVSIEEFYGILSQDNPTHTEKLLESASKAYYQNDSLSLQKYAGEERHKFELTQDKSFLYNSIMLESFLASVSNKEVDAKKVRELTDYLFSIEQWGKRELIILGNSMSFISTQTLNVLTKEIVYRTRLFGNSDSNQRIRISLLINAASEFLRRDELDLAKYYLDLVNDSGIPEVLLYERHELIFVMGSYLIKSGEVAEGRNLIEGCLETLRTLGAEKLLLAKESEYQELLNSTI
>NZ_CP020451.2|WP_080611584.1|760611_762189_-|ABC-transporter-ATP-binding-protein
MRTYILKYKYDNLVHILLLALNAAIFVSASVTLALMTNQLVSKRIQSFLALLGLEVGLYIIYLVLNYIIAVHQTKLIQKMTLSIRQSYLSKIIHHSFSEFRKSDIGEHLSVLNNDIQLIESNGFTSIYTLCSTVFTTLFSIIALLSYDVRIVLLAIFLTLCLTYLPKPFTNKMQKSMEIFSKANEELVSGISDQLYGYADVYYASRKQIFLRQVRSIVEKYIVQKIIFTKRKTSTETLMALFSVIAQMLILLLTGLLIIFGNITVGTIASVGQISGNIFNSLSTINQLQVTIKSVDPILKKFHDFPEGPKTCIATIQDVRFENVSYHFGDKAIFEGFTQTFKKGGKYAITGCSGSGKSTLLNIFLGNLKDYEGKILFGKLESKEIDENSIVSECAYVGSQTHIYNDTLRNNLTLWNEAITDTQIKKVLERVNLLSFLNRIDEQVSDGSFSEGQKQRIGLIRAFLKGCSVVIFDEATANLDHNNATRIEHLLLSDPNITYITVTHHLIKENEPYFDKIIRLGEGTE
>NZ_CP020451.2|WP_049545128.1|759739_760456_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKQGEPDPESNSALKFVLDRAKQAQVPKHVIDKAIDKAKGNTDETFVEGRYEGFGPNGSMIIVDTLTSNVNRTAANVRTAFGKNGGNMGASGSVSYMFDKKGVIVFAGEDADAIFEQLLEADVEVEDVEAEDGTITVYTEPTDLHKALEALRANGQEEFQVTELEMIPQTEVTLEGEDLEVFEGLIDALEADDDVQKVYHNVADM
>NZ_CP020451.2|WP_080611583.1|759284_759614_-|preprotein-translocase-subunit-YajC
MNMMLVLAIYVVAIVAYVAFSRRRQAKAQEDRFAGLAKGAEVETIGGLIAIVDEIDKENNRIVLDAEGVFLTFDLSRSIMKVITPAPTTETTKKTIIEEDSAIESSDEK
>NZ_CP020451.2|WP_080611582.1|758406_759156_-|isoprenyl-transferase
MFKFRKKSHQEVLDNIPNHIGIIMDGNGRWAKKRLQPRVMGHKAGMDALQKVTIEASQLGVKVLTVYAFSTENWSRPQDEVKFIMNLPVEFFNKYVPELDKNNVRILTIGDNSRLPKETLDALEKAVEQTKHNSGLVLNFALNYGGRAEIVSAVQAIAKEVEAGKLSPEAIDDDLIAKHLMTDKLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTDVFWPDFDQQGLRQAISDYNKRHRRFGGV
>NZ_CP020451.2|WP_080611591.1|771498_772755_+|ISL3-family-transposase
MRLIKNTTELIGIKDQNINISLVFETDTHIEIQAKLDSPAPSCPHCHGKMIKYDFQKPSKIPLLEQAGTPTLLRLKKRRFQCKSCRRVTVAETSIVEKNCQISNLVRQKVTQLLTEKVSLTDIARRLRVSTSTVYRKLDQFTFKEHYDKLPAIMSWDEFGFKKGELAFVAQNYETNELITILDNRCQTTIRNYFLKYPLKVRQKVRFITMDMSGAYMPLARRLFPNAEIIIDRFHIIQHLGRAFLKTRIAIMNQFDKKSLPYRALKNHWRLFQKDSRKLSLNAFYSKTFHQTLCPHEVVEKTLNFSEELTNYYNLYQLLLFHFQEKRGDEFFELIEENISKVNHYFKTVFRTFRKHKQYIKNALETHYSNAKLEGTNKLIKDIKRLGFGFKNFINFRKRVFITLNIQKEKTYLVLSRC
>NZ_CP020451.2|WP_080611592.1|772827_774177_-|glucose-6-phosphate-isomerase
MSHITFDYSKVLGKFVAPHEVDYFQPQVTAADEMIRKGTGAGADFLGWRDLPENYDREEFDRILKAAEKIKKDSDILVVIGIGGSYLGAKAAIDFLNNHFANLQTKEERKAPQILYAGNSISSSYLADLVDFVADKDFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWDTFVVPDNVGGRFSVLTAVGLLPIAASGADIKALMEGANAARKDYSSSKISENEAYQYAVLRNILYRKGYPVEILANYEPSLQYFGEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQYIQEGTRNVFETVIRVDKPRKNIIIPELEEDLDGLGYLQSKDVDFVNKKATDGVLLAHTDGGVPNMFVTIPEQDAFTLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKKNMFALLGKPGFEELGAELNARL
>NZ_CP020451.2|WP_002886451.1|774280_775096_-|endonuclease/exonuclease/phosphatase-family-protein
MKFLTLNTHSWMEEDAEGKFQTLKEQILKAQYDIICFQEVNQEIETSVVDTDAYYHALPSATPIHQDHFVRLLVEKLAEEGLQYHWTWAYNHIGYDHLNEGVAVLSRQPLTASEILVSDVDDPTDYHTRRVAVAETTVDGREVAVASVHLSWWDKGFQEEWARIEERFKAIGKPLILAGDFNNPAGREGHQAILASSLNLQDSFEVAKETTGSYTVGPGIDGWKGNEEPLRIDYVFASQDWTVERLSVIFDGNNQPLVSDHYGLEAELTFK
>NZ_CP020451.2|WP_073687441.1|775193_777380_-|PTS-glucose-transporter-subunit-IIA
MNKLKEKFGFEFWQKFGKALMVVIAVMPAAGLMISLGKTVAMINPNVAPLVITGGFLEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINRLTGSIFGVTSDILADKAATVHTVFGQSIKVSDYFISVLEAPALNMGVFVGIISGFIGATAFNKYYNFRKLPEALSFFNGKRFVPFVVILRSAIAAIVLAIVWPVIQSGINGFGMWIANSKETAPILAPFLFGTLERLLLPFGLHHMLTIPINYTQLGGTYEVLTGAAKGTEVLGQDPLWLAWVTDLANLKGAHPEQYKHVLESVTPARFKVGQMIGSFGILMGIVVAIYRNVDDDKKHQYKGMLTATALATFLTGVTEPIEYMFMFVATPLYIVYALVQGCAFAMADIVNLRVHSFGSIEFLTRTPLAINAGLAMDIVNFIWVTVLFGVIMFFIANFMIKKFDYATPGRNGNYEQADDASSESAGSASAGTSSASSQVINIINLLGGRANIVDVDACMTRLRVTVKDAEKVGTEEQWKAEGAMGLVMKGQGVQAIYGPKADVLKSDIQDVLDSGEVIPETLPSQMTAVQKAEANFKGVTDEVHSVADGQVINIEDVKDPVFSQKMMGDGFAVEPENGKIVSPVAGKVTSIFPTKHALGLVTDNGLEVLVHIGLDTVSLEGKPFDVKVTEGQTVAAGDLLVEANLDAIREAGRETSTVVVFTNADAIKSVKVEHTGKLAANAPVAKVEL
>NZ_CP020451.2|WP_080611593.1|777534_778473_-|AEC-family-transporter
MEIFLTSISGILVILGMILVGFVMGEKGWFDDKSRGLIAKLVTQIALPCYMLYTITQRFTATDLLKMLPELRFPALSMVILLGIATAVASIFAVKKERRGLFISMFFNSNTIFVGLPINQALFGDASIPYVLIYYMCNTTFFWTLGTYLIQRDGEGEAEFDLKTSLKKIFSPPLMGFMLGLIIVILHIKLPTFLASDLKYLGSLTTPLSMIFIGLSVSNAGVKQLVLKKDQVLILLGRFVVAPFLMAAIVYWAPLPTLMKQVFIIQSAMPVMTNAPVVAKLYGADSDYAAVMVTETTLATMVVIPILMVLMA
>NZ_CP020451.2|WP_038675203.1|778636_779449_-|metal-ABC-transporter-permease
MISELLAYDFMQRAILAVIAISIFSPILGLFLILRRQSLMSDTLSHVSLAGVAVGIFLGLSTTWMTLVVVVIAALVLEYLRVSYKHYMEISTAILMSMGLAVALILSNKAGSSSMSLDSYLFGSIITISPEQVRALFVIAAIILVLTLLFIRPMYLLTFDEDTAHVDGLPVRLMSLLFNIVTGIAIALMIPAAGSLLVSTIMILPAAIGMKIGQTFKSVIFWAIGIGLVGMLSGIFISYYWETPASATITLIFIAFFGLVSIFEPLLKAE
>NZ_CP020451.2|WP_002883613.1|779441_780149_-|metal-ABC-transporter-ATP-binding-protein
MRYITVEGLSFQYDAEPVLDNIHYHLDSGEFVTLTGENGAAKSTLIKATLGILKPKKGTVTISETNKDGKKLRMAYLPQQIASFNAGFPSTVYEFVKSGRYPRQGWFRRLTKHDLEHVQRALESVGMWENRHKQIGRLSGGQKQRAVIARIFASDPDIFVLDEPTTGMDAGTANTFYELMHHSAHKHGKSVLMITHDPEEVKEYTDRNIHLVRNQKLPWRCFNVHEKDGEEHKHD
>NZ_CP020451.2|WP_080611595.1|780150_780594_-|MarR-family-transcriptional-regulator
MLELEEQVNQLINQIVLKSENQHELLIGQCRSQVKLTNTQEHILMLLAEGRKTNSELAKTLNVSQAAVTKAVKTLVKEGMLEAKKDKDDGRVTYFVLTQEAHPIAQEHEEHHQETLGVYRSVLDQFDNQERQVIGRFLTTLAEKIEE
>NZ_CP020451.2|WP_080611596.1|780758_781736_-|tRNA-dihydrouridine-synthase-DusB
MTKLNSSFMIGNVEIPHRTVLAPMAGVTNSAFRTIAKEFGAGLVVMEMISEKGLLYNNETTLHMLHIDENEHPMSIQLFGGDAEGLKRAADFIQTNTKADIVDINMGCPVNKVVKNEAGAKWLKDPDKIYHIVKEVTSVLDIPLTVKMRTGWSNSDLAVENALAAESAGVSALAMHGRTREQMYTGHCDHETLAHVAKAITKIPFIGNGDVRSVQDAKLMIEELGVDAVMVGRAAMNNPYIFTQINHFFETGEELPELPFDKKLDIAEDHLKRLVDLKGEMIAVREFRGLAPHYLRGTAGAAKVRGEVSRAESVAQVEEIFATLR
>NZ_CP020451.2|WP_070576224.1|781728_782595_-|Hsp33-family-molecular-chaperone-HslO
MDKLIKTISESGSFRAYVLDSTETVRTAQEKHNTLSSSTVALGRTLIANQILAANQKGESKITVKVIGNSSFGHIISVADTKGHVKGYIQNPGVDIKKTATGEVLVGPFMGQGQFVSIIDYGTGNPYTSSTPLISGEIGEDFAYYLTESEQTPSAVGLNVLLDEEDKVKVAGGFMLQVLPGASEEEIARYEKRIQEMPAISTLLESDDHIEALLNAIYGDEPFKRLSEEELSFECDCSRERFENALLTLGKDELQAMKDEDHGAEIVCQFCQNKYEFSEADLEELIND

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Crispr_ID: NZ_CP020451_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020451_4

2249645-2249784

Orphan

Consensus_repeat	Method
ACTTTTGGTGTTGGTGGCGTTGGTGCCGTTGGACCTGTTGGTGGTGTTGGTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020451_4

>merge|NZ_CP020451|4|2249645-2249784|CRISPRCasFinder
ACTTTTGGTGTTGGTGGCGTTGGTGCCGTTGGACCTGTTGGTGGTGTTGGTTCAACCGGTTTTTCTGGAACTTCAACCACTTTTGGTGTTGGTGGCGTTGGTGCCGTTGGACCTGTTGGTGGTGTTGGTTCTTGTGGTTT

>NZ_CP020451|4|3|2249645-2249784|CRISPRCasFinder
ACTTTTGGTGTTGGTGGCGTTGGTGCCGTTGGACCTGTTGGTGGTGTTGGTTC	AACCGGTTTTTCTGGAACTTCAACCACTTTTGGT
GTTGGTGGCGTTGGTGCCGTTGGACCTGTTGGTGGTGTTGGTTCTTGTGGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020451.2\|WP_080612055.1\|2257679_2259086_-\|dipeptidase-PepV	unknown	unknown	gnl\|CDD\|235988
NZ_CP020451.2\|WP_037601325.1\|2243811_2244525_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|181323
NZ_CP020451.2\|WP_080612047.1\|2240170_2240902_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|226870
NZ_CP020451.2\|WP_048790943.1\|2239469_2240162_-\|capsular-biosynthesis-protein-CpsC	unknown	unknown	gnl\|CDD\|130079
NZ_CP020451.2\|WP_060775858.1\|2257056_2257641_-\|uracil-DNA-glycosylase-family-protein	unknown	unknown	gnl\|CDD\|381683
NZ_CP020451.2\|WP_080612052.1\|2247147_2248359_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_CP020451.2\|WP_080612051.1\|2245772_2246582_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP020451.2\|WP_080612050.1\|2244521_2245769_-\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238505
NZ_CP020451.2\|WP_080612054.1\|2252893_2256682_-\|YSIRK-type-signal-peptide-containing-protein	unknown	unknown	gnl\|CDD\|369832
NZ_CP020451.2\|WP_080612048.1\|2240902_2242363_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP020451.2\|WP_037597754.1\|2248479_2249160_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_CP020451.2\|WP_070656393.1\|2246600_2247146_-\|DUF1697-domain-containing-protein	unknown	unknown	gnl\|CDD\|226319
NZ_CP020451.2\|WP_080612049.1\|2242703_2243414_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275

Protein	Function_ID	Function_description	E-value
NZ_CP020451.2\|WP_080612055.1\|2257679_2259086_-\|dipeptidase-PepV	gnl\|CDD\|235988	PRK07318, PRK07318, dipeptidase PepV; Reviewed.	0
NZ_CP020451.2\|WP_037601325.1\|2243811_2244525_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|181323	PRK08250, PRK08250, glutamine amidotransferase; Provisional.	9.81767e-154
NZ_CP020451.2\|WP_080612047.1\|2240170_2240902_-\|tyrosine-protein-phosphatase	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.85068e-83
NZ_CP020451.2\|WP_048790943.1\|2239469_2240162_-\|capsular-biosynthesis-protein-CpsC	gnl\|CDD\|130079	TIGR01006, Capsular_polysaccharide_biosynthesis_protein_CapA, polysaccharide export protein, MPA1 family, Gram-positive type. This family contains members from Low GC Gram-positive bacteria; they are proposed to have a function in the export of complex polysaccharides. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	6.69241e-107
NZ_CP020451.2\|WP_060775858.1\|2257056_2257641_-\|uracil-DNA-glycosylase-family-protein	gnl\|CDD\|381683	cd10033, UDG_like, uncharacterized family of the uracil-DNA glycosylase superfamily. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil may arise from mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations; thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. UDG family 1 is the most efficient uracil-DNA glycosylase (UDG, also known as UNG) and shows a specificity for uracil in DNA. UDG family 2 includes thymine DNA glycosylase which removes uracil and thymine from G:U and G:T mismatches, and mismatch-specific uracil DNA glycosylase (MUG) which in Escherichia coli is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. UDG family 3 includes Human SMUG1 which can remove uracil and its oxidized pyrimidine derivatives from, single-stranded DNA and double-stranded DNA with a preference for single-stranded DNA. Pedobacter heparinus SMUG2, which is UDG family 3 SMUG1-like, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG family 4 includes Thermotoga maritima TTUDGA, a robust UDG which like family 1, acts on double-stranded and single-stranded uracil-containing DNA. UDG family 5 (UDGb) includes Thermus thermophilus HB8 TTUDGB which acts on double-stranded uracil-containing DNA; it is a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA except for the C/I base pair, as well as a xanthine DNA glycosylase which acts on both double-stranded and single-stranded xanthine-containing DNA. UDG family 6 hypoxanthine-DNA glycosylase lacks any detectable UDG activity; it excises hypoxanthine. Other UDG families include one represented by Bradyrhizobium diazoefficiens Blr0248 which prefers single-stranded DNA and removes uracil, 5-hydroxymethyl-uracil or xanthine from it.	2.82164e-103
NZ_CP020451.2\|WP_080612052.1\|2247147_2248359_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP020451.2\|WP_080612051.1\|2245772_2246582_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	1.07334e-164
NZ_CP020451.2\|WP_080612050.1\|2244521_2245769_-\|chloride-channel-protein	gnl\|CDD\|238505	cd01033, ClC_like, Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. This superfamily lacks any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge.	1.28276e-90
NZ_CP020451.2\|WP_080612054.1\|2252893_2256682_-\|YSIRK-type-signal-peptide-containing-protein	gnl\|CDD\|369832	pfam08363, GbpC, Glucan-binding protein C. This domain is found in the Streptococcus Glucan-binding protein C (GbpC) and also in surface protein antigen (Spa)-family proteins which show sequence similarity to GbpC.	2.61386e-22
NZ_CP020451.2\|WP_080612048.1\|2240902_2242363_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	2.3437e-56
NZ_CP020451.2\|WP_037597754.1\|2248479_2249160_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	3.49251e-117
NZ_CP020451.2\|WP_070656393.1\|2246600_2247146_-\|DUF1697-domain-containing-protein	gnl\|CDD\|226319	COG3797, COG3797, Uncharacterized protein conserved in bacteria [Function unknown].	1.37258e-42
NZ_CP020451.2\|WP_080612049.1\|2242703_2243414_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	3.34312e-152

>NZ_CP020451.2|WP_037597754.1|2248479_2249160_-|ribose-5-phosphate-isomerase-RpiA
MEELKKIAGVTAAKYVEDGMVVGLGTGSTAYFFVEEIGRRIKEEGLSVVGVTTSSQTTKQAKGLGIPLKAVDDIDSIDVTVDGADEVDPQLNGIKGGGGALLMEKIVATPTKEYIWVVDESKMVNQLGAFKLPVEVVQYGADRLYRVFESKGYKPSFRLSEEGNRFVTDMKNYIIDLDLGKIENPVALGEELKAMTGVVDHGLFNGMVNKVIVAGKDGVKVVEVKA
>NZ_CP020451.2|WP_080612052.1|2247147_2248359_-|phosphopentomutase
MSKFNRMHLVVLDSVGIGAAPDANDFVNAGVPDGASDTLGHISKSVGLNVPNMAKLGLGNIPRETPLKTVPAESNPTGYATKLQEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIEDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRTSNRRDLAVSPFAPTVLDKLNEAGIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDNLIKAMTSKDFKHGFSFTNLVDFDALYGHRRDPHGYRDCLHEFDQRLPEIIAAMREDDLLMITADHGNDPTYAGTDHTREYIPFLAYSPSFKGNGLIPVGHFSDISATVAENFGVDKAMIGESFLDKLI
>NZ_CP020451.2|WP_070656393.1|2246600_2247146_-|DUF1697-domain-containing-protein
MKRYAFLVRGINVGGRHKVVMEEFCRELEELGMSHVSSYINSGNLFFDSTLMKEELLLVLEEFLNKAYPFIKVFSLFTLEDYQNEVASLPKWWEDDFYRKDVLLFTERLDKNEMKKIINSLELKDEILHFGQLGVYWVKYDKSTYSQTAYHKKLLKTPFYPDITIRNARTFSKIGHFLRMK
>NZ_CP020451.2|WP_080612051.1|2245772_2246582_-|purine-nucleoside-phosphorylase
MSLLEKIRVTQAFLESKGIENPEFGLILGSGLGELAEEVEDAVVIDYADIPNWGQSTVVGHAGKLVYGTLSGRKVLALQGRFHFYEGNPLEVVTFPVRVMKALGCEGVVVTNAAGGIGFGPGTLMAITDHINMTGQNPLIGENLDDFGPRFPDMSKAYTPEYRETAHKMADKLGIKLDDGVYIGVTGPSYETPAEIRAYKTLGADAVGMSTVPEVIIAAHSGLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGDFKGLLKAILAEL
>NZ_CP020451.2|WP_080612050.1|2244521_2245769_-|chloride-channel-protein
MIARGIKPITSLPKSTRLSLAVFGTGIASGLVGILCHYLLEFIQILVFGNDKSNLLSQFNSVSPFRRFAVLLVVGVLASLFWYFLQRRVSLLSISKAKQLVGKKSPNFLGQSLHALVQVAIVGAGASVGKEAAPRELGALCAGSLSKKLGLEIPERQLMIACGAGAGLAAVYQVPFASTLFVLETLGVAWKLKNIGIILVTTYLSAYCARPIVGGKAIYLVDKVSLHPTSLIQILVLTLFVTPLALIFKVLAKKASKSRITDKHILWTMPVSFIILGGIVAFYPIIMGNGQVLAQWMFSGGTSEYLPILLVIKGLIVCLLLWSGTYGGTLTPSFTLGVGSGFLLTRCLETFGLSLNPNLGMLLGATIFLVTTLDAPLTGIALVLGFTGQGGLVAVPLILAGLLSRIINNKWKKKQ
>NZ_CP020451.2|WP_037601325.1|2243811_2244525_-|type-1-glutamine-amidotransferase
MNIHFILHETFEVPGAYLKWAQDRGHNITSTKVYEEEVLPETVEGIDFLIVMGGPQSPDEDRQTFPYYDPNAEIAFMQKAIAADIYIVGVCLGAQLLSVAYGGKYEHSPEREIGVFPITLTDDGLADEHVKGFGTTLNTGHWHGDMPGLTDNAVVLATSQGCPRQIIRFSPKHYAFQAHLEFDSQAIDLLIAADGEEHLRKQNKELPFVQTPEQLRTNDYSEMNKKLYDFLDSLTQA
>NZ_CP020451.2|WP_080612049.1|2242703_2243414_-|purine-nucleoside-phosphorylase
MSIHIAAKQGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGERVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNEDVHVRELVLAQAAATNSNIIRNDWPQYDFPQIASFNLLDKAYHIAKELGMTTHVGNVLSSDVFYSNYGEKNIELGKWGVKAVEMEAAALYYLAAQHQVDALAIMTISDSLVNPDEDTTAEERQNTFTDMMRVGLETLIAD
>NZ_CP020451.2|WP_080612048.1|2240902_2242363_-|LCP-family-protein
MSSRTNRKQKRTSNRSWGMVNIGLTILYAILALVLLFTMFNYNFLSFRFLNIIITIGLLVVLAISIFLQKTKKSPLVTTVVLVIFSLVSLVGIFGFKQMIDITNRMNQTAAFSEVEMSIVVPKESDIKDVSQLTSVQAPTKVDKNNIETLMSALKKDKKVDVKVDDVASYQEAYDNLKSGKSKAMVLSGSYASLLESVDSNYASNLKTIYTYKIKKKNNNSAKQVDSKVFNIYISGIDTYGSISTVSRSDVNIIMTVNMNTHKILLTTTPRDAYVKIPGGGADQYDKLTHAGIYGVETSEQTLENLYDIKIDYYARINFTSFLKLIDQLGGVTVHNDQAFTSLHGKFDFPVGDIQMNSEQALGFVRERYSLDGGDNDRGKNQEKVISAIVNKLASLKSVSNFTSIVNNLQDSVQTNMSLDTINALANTQLDSGSKFTVTSQAVTGTGSTGQLTSYAMPNSSLYMMKLDDSSVASASQAIKNLMEEK
>NZ_CP020451.2|WP_080612047.1|2240170_2240902_-|tyrosine-protein-phosphatase
MIDVHSHIVFDVDDGPKTLEESLDLIGESYAQGVRKIVSTSHRRKGMFETPEDKIFANFSKVKAEAEALYPDLTIYYGGELYYTSDIVEKLEKNLIPRMHNTQFALIEFSARTTWKEIHSGLSNVLRAGVTPIVAHIERYDALEENADRVREIINMGCYTQVNSSHVLKPKLFGDKDKVRKKRVRYFLEKNLVHMVASDMHNLGPRPPFMKDAYAIIEKTYGTRRARNLFIENPQTLLENQYI
>NZ_CP020451.2|WP_048790943.1|2239469_2240162_-|capsular-biosynthesis-protein-CpsC
MTQENTKRVEIDVLALLQKLWTKKVFILFTAFYVAVFAFLGTYFLIQPTYTSSTRIYVVNQANDGKNLSAQDLQAGTFLTKDYKEIITSNDVLSEVIKDEKLNMTEAELAKMISVNIPTDTRLISISVNAKTGQDAQTLANKVREVASEKIKNVTKVEDVTTLEEAKLPESPSSPNIKRNVLLGAVLGGFLAVVGVLVREILDDRIRRPEDVEDALGMTLLGIVPDTDKI
>NZ_CP020451.2|WP_080612054.1|2252893_2256682_-|YSIRK-type-signal-peptide-containing-protein
MGRKVSQRFSIRKYSFGAASVLLGTTILAMGATGVHADEVSTSAATDTPLSASVLTDSAADPATTVDHSEKQVVSVKEEGNTTVTTSVVTTDSLEDAKASAVKEGVEVEETAPQTHTSLEGAIANNQAQSKEINTVVYDYQKAKEDHKKDVAEYEKAKAEYDAKVAEKAAADKANAASKAQYDTDQASYEKGLAKYQADKKAYDAALEEYNTQKLTYDSKVAEKAASDAANAKSEADYKVQLAVYETAKKNYEAAMAQYTKDKAKYDAEKEAYDAKVAEKVRTEIENKDAQEQYEKDLATYNAAYEKYQTDLAAYKTAKAAYDAKVAERAAADAANAKAKSKYNAEMVTYNAALSEYKANKALYDAALAEYNTKKAAYDVKVAEKTQAEITDKAAQEQYEKDLTAYNTAYVKYQTDLAAYNTAKAAYDAKVAEKAVADKANADAKAKYDAEMAVYNTAKAQYDKDLQEYQAKKAQYDKDKAAYDKLVAIKAEEDAAKAKYEVELAKYNVDLEQYGKDFATYQTKLAEYQTALAQYKDAKEAYDKYINDNGFQDLKDVETVQDLTFQREGGAIHTINGISAYLTRDAQSRLNTSNVHQYDSNKLEASDIVATSPWANNETEYIQVKEGDKFVVTYDNLNQSSMREDTDMHPIKRVIYRYEILSLPSNDGKGIAAVSSDPTVTLTVGASTDQNKPVKVAVDIEFYDGNGNKFDLTQHNAIVALNSLNHWTGASYVDSGDKPRALTVEAKDKDGKTVRGTWDPYADGSSMSIENNAVVVKNGTADFGTADVTISAENPLKIVAQKATWNGSEFTVSEETVIDATAVNASGAGNGHSIGTDEFTLDDKDDVIGSYTIDPTSGRIIFTPKKKFENVEHQESVNVGNNKYIPIPNSSVSYDSATKEVTSFKDNQYIEHGSIFNGESSTTLEGWDNPSSPYLYYGGAGLKMADGHLVFTANGANAAGQPTVYWFAINSNVGIPKNPGEAPKEPTAPEEPKAPTPPTITLEVLPAVPTEPTPPTAPTAPTEPNYTVVTVDAEEPKAPTEPKAPTPPTPTVVEVPAEPSKPEEPKAPTPPTEPNYTVVTVDAEEPKAPTEPKAPTPPTPALVEVPVEPRKITAPVEPKAPTPPTPVVVEVPGEPTKPTPPTEPTAPTPPTMVTVNVPNKPVSPKELVAPKVKWHKNYLVERVTRPVPTTPPTPQKPKTPRTPTGPSVTPTSSVVAKQETERTNSAVLPETGDSNQKLASVTGLGFLSMALTGLWSARKRKH
>NZ_CP020451.2|WP_060775858.1|2257056_2257641_-|uracil-DNA-glycosylase-family-protein
METLEELTQAIMADEQNKVYTEQGIKPLFSIPKTARINIVGQAPGIRAQESGLYWNDPSGDNLRDWMGVSREEFYESGMFAIVPMDFYFPGHGKSGDLPPRKGFADKWHEKVLALAPDIQLTILVGNYAQHYYLHQKSSAKLTDTVKHYKDYLPEFFPLVHPSPRNNIWQAKNPWFMEEVVPDLKALVKKILSR
>NZ_CP020451.2|WP_080612055.1|2257679_2259086_-|dipeptidase-PepV
MTIDFRAKVDKRKDALMEDLFGLLRINSERDDSKVDDKHPFGPGPVKALEHFLALAERDGYKTRNIDNYAGDFEFGQGDEVLGIFAHLDVVPAGSGWDTDPYEPVIKDGKLYARGSSDDKGPTMACYYALKIIKELELPVSKRVRFIVGTDEESGWGDMEYYFAHNGLKDPDFGFSPDAEFPIINGEKGNITAYLHFEGQNDGDFSLVSFNGGLRENMVPESASADFTGPITLKELEAKLADFVAEQEVTGQVTEEAGVFHVTIHGKSAHGMMPQNGINGATYLAHFLSQFDFQGNAKTYLDIIAETLHKDFFAEKTGLAYTDPKMGELTMNAGVFNFSKESEDNTIALNFRYPQGVDTDAIKAGLEKLEGPKAVSLSEHGHVPHYVPVDDPMVETLLSVYEKQTGLKGHEQIIGGGTFGRLLKRGVAYGAMFPGYVNTMHQANEFTEVEDLYRAAAIYAEAIYELIK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP020451_1	1.1\|43764\|25\|NZ_CP020451\|CRISPRCasFinder	43764-43788	25	MK448851	Streptococcus phage Javan14, complete genome	27770-27794	5	0.8
NZ_CP020451_4	4.1\|2249698\|34\|NZ_CP020451\|CRISPRCasFinder	2249698-2249731	34	NC_015417	Clostridium botulinum BKT015925 plasmid p1BKT015925, complete sequence	19387-19420	10	0.706
NZ_CP020451_2	2.2\|212282\|34\|NZ_CP020451\|PILER-CR	212282-212315	34	MN693484	Marine virus AFVG_25M226, complete genome	950-983	11	0.676

1. spacer 1.1|43764|25|NZ_CP020451|CRISPRCasFinder matches to MK448851 (Streptococcus phage Javan14, complete genome) position: , mismatch: 5, identity: 0.8

cctcgctttttcatttctgggctcg	CRISPR spacer
ataagctttttcatttctgggctag	Protospacer
 .  ******************* *

2. spacer 4.1|2249698|34|NZ_CP020451|CRISPRCasFinder matches to NC_015417 (Clostridium botulinum BKT015925 plasmid p1BKT015925, complete sequence) position: , mismatch: 10, identity: 0.706

aaccggtttttctggaacttcaaccacttttggt	CRISPR spacer
tttaagcttttctggaacttcatcctcttttaat	Protospacer
  . .*.*************** ** *****..*

3. spacer 2.2|212282|34|NZ_CP020451|PILER-CR matches to MN693484 (Marine virus AFVG_25M226, complete genome) position: , mismatch: 11, identity: 0.676

ttcactctttggtgtttctgatgctgaagtctcg	CRISPR spacer
tggcggtattgggctttctgatgctgaagtctat	Protospacer
*     . ****  ******************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

290207 : 297959

Streptococcus_phage(85.71%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001813542.1\|290207_290453_+	hypothetical protein	A0A1B0RXA7	Streptococcus_phage	2.6e-37	98.8
WP_000806926.1\|290449_290785_+	hypothetical protein	NA	NA	NA	NA
WP_000567222.1\|290797_291166_+	hypothetical protein	A0A1B0RXA8	Streptococcus_phage	1.1e-58	97.5
WP_001072467.1\|291152_291452_+	hypothetical protein	A0A1B0RX98	Streptococcus_phage	1.8e-48	96.0
WP_080611460.1\|291569_293033_-	Msr family ABC-F type ribosomal protection protein	A0A1B0RXA0	Streptococcus_phage	2.8e-251	96.9
WP_000417519.1\|293152_294370_-	macrolide efflux MFS transporter Mef(A)	A0A2K5B2B5	Erysipelothrix_phage	5.1e-198	90.6
WP_000873143.1\|294755_294926_-	hypothetical protein	A0A1X9I6E4	Streptococcus_phage	3.7e-22	98.2
WP_080611461.1\|295871_297959_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.2e-114	36.2

DBSCAN-SWA_2

310572 : 321476

Streptococcus_phage(87.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073950844.1\|310572_311739_-	chorismate synthase	A0A291AU41	Pandoravirus	9.3e-40	34.9
WP_013990891.1\|311739_312807_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_080611467.1\|312819_313677_-	shikimate dehydrogenase	NA	NA	NA	NA
WP_080611468.1\|313666_314344_-	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.4e-114	92.4
WP_080611469.1\|314340_315504_-	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	8.5e-211	94.6
WP_037620394.1\|315665_317852_+	LTA synthase family protein	W6LM83	Streptococcus_phage	0.0e+00	95.0
WP_002886071.1\|318026_318212_+	hypothetical protein	W6LMT3	Streptococcus_phage	1.9e-24	93.4
WP_002886048.1\|318364_319669_-	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	1.4e-246	99.5
WP_021144479.1\|319874_320330_+	YueI family protein	W6LLD2	Streptococcus_phage	2.3e-66	83.4
WP_021144480.1\|320360_321476_-	glycerate kinase	W6LM47	Streptococcus_phage	9.2e-138	86.6

DBSCAN-SWA_3

608997 : 614444

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080611551.1\|608997_610317_-	DEAD/DEAH box helicase	A0A1X9I5S6	Streptococcus_phage	2.0e-123	52.8
WP_038675335.1\|610371_610998_+	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	3.5e-70	62.3
WP_002883742.1\|611099_612026_+	cysteine synthase A	A0A1X9I5K7	Streptococcus_phage	9.4e-144	81.8
WP_002890017.1\|612175_612835_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	1.5e-66	59.2
WP_002883761.1\|612969_613680_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	6.3e-15	26.9
WP_021143582.1\|613679_614444_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.9e-15	24.8

DBSCAN-SWA_4

1070701 : 1108468

Streptococcus_phage(58.82%)

terminase,tRNA,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003092098.1\|1070701_1071958_-\|tRNA	tyrosine--tRNA ligase	A0A1S6UA79	Serratia_phage	3.3e-75	41.6
WP_080611676.1\|1072059_1074483_+	penicillin-binding protein	NA	NA	NA	NA
WP_080611678.1\|1074842_1078424_+	DNA-directed RNA polymerase subunit beta	A0A2P0VMZ3	Tetraselmis_virus	1.7e-39	25.7
WP_037603707.1\|1078524_1082163_+	DNA-directed RNA polymerase subunit beta'	R4TQM7	Phaeocystis_globosa_virus	5.8e-64	25.6
WP_080611679.1\|1082325_1082688_+	DUF1033 family protein	NA	NA	NA	NA
WP_080611681.1\|1082769_1083711_+	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_125871313.1\|1083592_1084693_+	type II secretion system F family protein	NA	NA	NA	NA
WP_080612063.1\|1084769_1086206_-	recombinase family protein	A0A2H4J6X5	uncultured_Caudovirales_phage	1.0e-261	95.6
WP_080612064.1\|1086356_1086941_-	hypothetical protein	A0A2H4J009	uncultured_Caudovirales_phage	6.4e-74	95.9
WP_080611682.1\|1086955_1087333_-	ImmA/IrrE family metallo-endopeptidase	F8HGP6	Streptococcus_phage	4.2e-58	90.8
WP_080611684.1\|1087339_1087705_-	helix-turn-helix domain-containing protein	O48389	Streptococcus_phage	3.7e-51	87.6
WP_080611685.1\|1087873_1088077_+	helix-turn-helix transcriptional regulator	A0A191KC33	Streptococcus_virus	5.9e-27	89.6
WP_080611687.1\|1088137_1088881_+	phage antirepressor KilAC domain-containing protein	A0A2P0VK28	Streptococcus_phage	1.2e-101	75.1
WP_080611688.1\|1089278_1089605_+	transcriptional regulator	K4JW96	Streptococcus_phage	1.1e-25	59.8
WP_080611690.1\|1089873_1090056_+	hypothetical protein	NA	NA	NA	NA
WP_192573914.1\|1090069_1090213_+	hypothetical protein	A0A2H4J6W5	uncultured_Caudovirales_phage	2.1e-18	91.1
WP_080611691.1\|1090468_1091881_+	hypothetical protein	F8HGQ4	Streptococcus_phage	5.9e-89	50.1
WP_080611693.1\|1091886_1092207_+	hypothetical protein	A0A2H4J2X0	uncultured_Caudovirales_phage	2.5e-35	71.7
WP_080611694.1\|1092242_1092425_+	hypothetical protein	Q708Q3	Streptococcus_phage	1.3e-09	61.5
WP_080611697.1\|1093494_1094466_+	DUF1351 domain-containing protein	A0A2I6QQU5	Streptococcus_phage	1.1e-131	81.1
WP_080611699.1\|1094462_1094966_+	single-stranded DNA-binding protein	A0A2H4J1H8	uncultured_Caudovirales_phage	2.1e-81	90.4
WP_080611701.1\|1094974_1095436_+	RusA family crossover junction endodeoxyribonuclease	A0A2H4J7B7	uncultured_Caudovirales_phage	5.2e-79	92.8
WP_080611702.1\|1095432_1095669_+	hypothetical protein	A0A2H4J4H9	uncultured_Caudovirales_phage	5.5e-32	82.1
WP_192573905.1\|1095659_1095830_+	hypothetical protein	W6LMV1	Streptococcus_phage	6.1e-17	78.2
WP_192573906.1\|1095826_1095982_+	hypothetical protein	F8HGR6	Streptococcus_phage	1.2e-14	74.5
WP_080612065.1\|1095986_1096493_+	DUF1642 domain-containing protein	A0A1S5PS22	Streptococcus_phage	1.7e-43	49.7
WP_080611704.1\|1096768_1097077_+	DUF1372 family protein	A0A286QMU5	Streptococcus_phage	6.0e-39	88.0
WP_080612066.1\|1097079_1097784_+	DUF1340 domain-containing protein	A0A2H4IZZ3	uncultured_Caudovirales_phage	4.4e-93	72.1
WP_080611705.1\|1098523_1098940_+	autolysin	C5IUI9	Streptococcus_phage	3.8e-68	92.0
WP_080612067.1\|1099075_1099564_+\|terminase	terminase small subunit	L0P3M6	Streptococcus_phage	1.1e-53	74.0
WP_105257716.1\|1099550_1100855_+\|terminase	PBSX family phage terminase large subunit	A0A286QNX6	Streptococcus_phage	1.0e-236	91.0
WP_105257717.1\|1102382_1103603_+\|capsid	phage minor capsid protein	A0A286QMS2	Streptococcus_phage	2.4e-187	78.4
WP_080611708.1\|1103692_1104268_+	phage scaffolding protein	A0A2H4JBH4	uncultured_Caudovirales_phage	1.0e-63	69.9
WP_080611710.1\|1104290_1105112_+\|capsid	N4-gp56 family major capsid protein	A0A2H4JBI0	uncultured_Caudovirales_phage	1.7e-117	76.3
WP_080612068.1\|1105685_1106027_+\|capsid	minor capsid protein	A0A286QMS6	Streptococcus_phage	6.0e-56	93.7
WP_080611711.1\|1106026_1106461_+\|capsid	minor capsid protein	A0A286QMS1	Streptococcus_phage	2.2e-55	89.0
WP_080611713.1\|1106787_1107324_+	hypothetical protein	A0A286QNY7	Streptococcus_phage	7.2e-72	79.3
WP_080611714.1\|1107441_1107837_+	hypothetical protein	A0A286QNZ4	Streptococcus_phage	3.5e-39	70.1
WP_080611716.1\|1107805_1108468_+	bacteriophage Gp15 family protein	A0A286QMS7	Streptococcus_phage	8.3e-102	84.1

DBSCAN-SWA_5

1113085 : 1158554

Streptococcus_phage(71.43%)

terminase,holin,tail,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080611718.1\|1113085_1113814_+	hypothetical protein	A0A286QMT6	Streptococcus_phage	9.7e-112	80.2
WP_080611719.1\|1113810_1115646_+	GBS Bsp-like repeat-containing protein	A0A1L2JXU3	Streptococcus_phage	1.6e-171	58.6
WP_080611721.1\|1115648_1118141_+	hypothetical protein	A0A286QMM0	Streptococcus_phage	4.7e-41	55.9
WP_080611722.1\|1118184_1118619_+\|holin	phage holin family protein	F8HGP0	Streptococcus_phage	3.2e-62	87.5
WP_080611725.1\|1118611_1118842_+\|holin	phage holin	A0A2I6QR05	Streptococcus_phage	2.2e-30	90.8
WP_080611727.1\|1118846_1119299_+	hypothetical protein	A0A2I6QR28	Streptococcus_phage	1.1e-70	89.3
WP_080611728.1\|1119312_1119642_+	hypothetical protein	A0A2H4J011	uncultured_Caudovirales_phage	1.4e-41	84.3
WP_080611730.1\|1119646_1119919_+	hypothetical protein	A0A2H4J827	uncultured_Caudovirales_phage	4.5e-22	71.6
WP_080611731.1\|1119937_1121323_+	CHAP domain-containing protein	A0A286QS50	Streptococcus_phage	9.4e-249	89.6
WP_080612063.1\|1121999_1123436_-	recombinase family protein	A0A2H4J6X5	uncultured_Caudovirales_phage	1.0e-261	95.6
WP_080612064.1\|1123586_1124171_-	hypothetical protein	A0A2H4J009	uncultured_Caudovirales_phage	6.4e-74	95.9
WP_080611682.1\|1124185_1124563_-	ImmA/IrrE family metallo-endopeptidase	F8HGP6	Streptococcus_phage	4.2e-58	90.8
WP_080611684.1\|1124569_1124935_-	helix-turn-helix domain-containing protein	O48389	Streptococcus_phage	3.7e-51	87.6
WP_080611685.1\|1125103_1125307_+	helix-turn-helix transcriptional regulator	A0A191KC33	Streptococcus_virus	5.9e-27	89.6
WP_080611687.1\|1125367_1126111_+	phage antirepressor KilAC domain-containing protein	A0A2P0VK28	Streptococcus_phage	1.2e-101	75.1
WP_080611688.1\|1126508_1126835_+	transcriptional regulator	K4JW96	Streptococcus_phage	1.1e-25	59.8
WP_080611690.1\|1127103_1127286_+	hypothetical protein	NA	NA	NA	NA
WP_192573914.1\|1127299_1127443_+	hypothetical protein	A0A2H4J6W5	uncultured_Caudovirales_phage	2.1e-18	91.1
WP_080611691.1\|1127698_1129111_+	hypothetical protein	F8HGQ4	Streptococcus_phage	5.9e-89	50.1
WP_080611693.1\|1129116_1129437_+	hypothetical protein	A0A2H4J2X0	uncultured_Caudovirales_phage	2.5e-35	71.7
WP_080611694.1\|1129472_1129655_+	hypothetical protein	Q708Q3	Streptococcus_phage	1.3e-09	61.5
WP_080611697.1\|1130724_1131696_+	DUF1351 domain-containing protein	A0A2I6QQU5	Streptococcus_phage	1.1e-131	81.1
WP_080611699.1\|1131692_1132196_+	single-stranded DNA-binding protein	A0A2H4J1H8	uncultured_Caudovirales_phage	2.1e-81	90.4
WP_080611701.1\|1132204_1132666_+	RusA family crossover junction endodeoxyribonuclease	A0A2H4J7B7	uncultured_Caudovirales_phage	5.2e-79	92.8
WP_080611702.1\|1132662_1132899_+	hypothetical protein	A0A2H4J4H9	uncultured_Caudovirales_phage	5.5e-32	82.1
WP_192573905.1\|1132889_1133060_+	hypothetical protein	W6LMV1	Streptococcus_phage	6.1e-17	78.2
WP_192573906.1\|1133056_1133212_+	hypothetical protein	F8HGR6	Streptococcus_phage	1.2e-14	74.5
WP_080612065.1\|1133216_1133723_+	DUF1642 domain-containing protein	A0A1S5PS22	Streptococcus_phage	1.7e-43	49.7
WP_080611704.1\|1133998_1134307_+	DUF1372 family protein	A0A286QMU5	Streptococcus_phage	6.0e-39	88.0
WP_080612066.1\|1134309_1135014_+	DUF1340 domain-containing protein	A0A2H4IZZ3	uncultured_Caudovirales_phage	4.4e-93	72.1
WP_080611705.1\|1135752_1136169_+	autolysin	C5IUI9	Streptococcus_phage	3.8e-68	92.0
WP_080612067.1\|1136304_1136793_+\|terminase	terminase small subunit	L0P3M6	Streptococcus_phage	1.1e-53	74.0
WP_080611710.1\|1141514_1142336_+\|capsid	N4-gp56 family major capsid protein	A0A2H4JBI0	uncultured_Caudovirales_phage	1.7e-117	76.3
WP_080611733.1\|1142516_1142924_+	hypothetical protein	C5IUJ7	Streptococcus_phage	1.8e-35	58.1
WP_080612068.1\|1142910_1143252_+\|capsid	minor capsid protein	A0A286QMS6	Streptococcus_phage	6.0e-56	93.7
WP_070439692.1\|1143251_1143611_+\|capsid	minor capsid protein	A0A286QMS1	Streptococcus_phage	8.3e-56	89.8
WP_080611735.1\|1143610_1144015_+\|capsid	minor capsid protein	A0A286QML6	Streptococcus_phage	3.1e-67	94.8
WP_080611713.1\|1144014_1144551_+	hypothetical protein	A0A286QNY7	Streptococcus_phage	7.2e-72	79.3
WP_080611737.1\|1144668_1145031_+	hypothetical protein	A0A286QNZ4	Streptococcus_phage	1.1e-39	70.3
WP_080611716.1\|1145033_1145696_+	bacteriophage Gp15 family protein	A0A286QMS7	Streptococcus_phage	8.3e-102	84.1
WP_080611739.1\|1145712_1150320_+\|tail	phage tail protein	C5IUK3	Streptococcus_phage	2.0e-263	91.3
WP_080611718.1\|1150316_1151045_+	hypothetical protein	A0A286QMT6	Streptococcus_phage	9.7e-112	80.2
WP_080611719.1\|1151041_1152877_+	GBS Bsp-like repeat-containing protein	A0A1L2JXU3	Streptococcus_phage	1.6e-171	58.6
WP_080611721.1\|1152879_1155372_+	hypothetical protein	A0A286QMM0	Streptococcus_phage	4.7e-41	55.9
WP_080611722.1\|1155415_1155850_+\|holin	phage holin family protein	F8HGP0	Streptococcus_phage	3.2e-62	87.5
WP_080611725.1\|1155842_1156073_+\|holin	phage holin	A0A2I6QR05	Streptococcus_phage	2.2e-30	90.8
WP_080611727.1\|1156077_1156530_+	hypothetical protein	A0A2I6QR28	Streptococcus_phage	1.1e-70	89.3
WP_080611728.1\|1156543_1156873_+	hypothetical protein	A0A2H4J011	uncultured_Caudovirales_phage	1.4e-41	84.3
WP_080611730.1\|1156877_1157150_+	hypothetical protein	A0A2H4J827	uncultured_Caudovirales_phage	4.5e-22	71.6
WP_080611731.1\|1157168_1158554_+	CHAP domain-containing protein	A0A286QS50	Streptococcus_phage	9.4e-249	89.6

DBSCAN-SWA_6

1163556 : 1210225

Streptococcus_phage(37.5%)

transposase,tRNA,bacteriocin,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064523497.1\|1163556_1164213_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013991259.1\|1164290_1164737_+	hypothetical protein	NA	NA	NA	NA
WP_013991258.1\|1164849_1165512_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013991257.1\|1165538_1166309_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	6.2e-32	35.4
WP_013991256.1\|1166324_1167392_-	glutamyl aminopeptidase	NA	NA	NA	NA
WP_080611751.1\|1167491_1167776_+	DUF4651 domain-containing protein	NA	NA	NA	NA
WP_013991254.1\|1167772_1168087_+	thioredoxin family protein	NA	NA	NA	NA
WP_080611753.1\|1168090_1168615_+	hypothetical protein	NA	NA	NA	NA
WP_002885779.1\|1168647_1169271_+\|tRNA	DUF4479 and tRNA-binding domain-containing protein	NA	NA	NA	NA
WP_070576695.1\|1169536_1170214_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_070576692.1\|1170641_1171034_+	single-stranded DNA-binding protein	A1EAD1	Streptococcus_phage	3.3e-26	47.7
WP_060971580.1\|1171803_1172322_+	nucleoside deaminase	NA	NA	NA	NA
WP_002892002.1\|1172709_1172877_-\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_080611755.1\|1172897_1173056_-\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
WP_070576686.1\|1173476_1174316_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_070576682.1\|1174429_1175182_+	HAD family hydrolase	NA	NA	NA	NA
WP_070576679.1\|1175267_1175966_+	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	NA	NA	NA	NA
WP_070576676.1\|1176041_1177175_+	N-acetyldiaminopimelate deacetylase	NA	NA	NA	NA
WP_070576673.1\|1177243_1177771_+	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_002891988.1\|1177761_1178436_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_080611756.1\|1178481_1179396_-	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	1.1e-75	51.2
WP_060971571.1\|1179413_1180436_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_070576671.1\|1180554_1181115_-	MptD family putative ECF transporter S component	NA	NA	NA	NA
WP_070576667.1\|1181123_1181915_-	formate/nitrite transporter family protein	NA	NA	NA	NA
WP_002885631.1\|1182031_1183282_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL82	Lactobacillus_phage	7.6e-56	52.7
WP_038676836.1\|1183300_1183903_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	2.0e-54	53.7
WP_038676834.1\|1184110_1184557_+	dUTP diphosphatase	Q332E8	Clostridium_botulinum_C_phage	8.5e-34	50.7
WP_038676832.1\|1184567_1185035_+	cysteine hydrolase	NA	NA	NA	NA
WP_072903619.1\|1185031_1186393_+	DNA repair protein RadA	NA	NA	NA	NA
WP_002885783.1\|1186478_1187174_+	TIGR00266 family protein	NA	NA	NA	NA
WP_038676829.1\|1187324_1187822_+	carbonic anhydrase	NA	NA	NA	NA
WP_038676827.1\|1187917_1188271_-	DUF3397 domain-containing protein	NA	NA	NA	NA
WP_002885648.1\|1188442_1188868_+	50S ribosomal protein L11	NA	NA	NA	NA
WP_002885800.1\|1188967_1189657_+	50S ribosomal protein L1	NA	NA	NA	NA
WP_037611118.1\|1189837_1191808_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_080611591.1\|1191842_1193099_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	5.4e-126	55.4
WP_037611119.1\|1193462_1194917_+\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_002885760.1\|1195367_1196675_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_014635088.1\|1196734_1197625_+	hypothetical protein	NA	NA	NA	NA
WP_105257718.1\|1197646_1198927_+	hypothetical protein	NA	NA	NA	NA
WP_080611758.1\|1198950_1200267_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_037600060.1\|1200268_1201012_+	response regulator transcription factor	NA	NA	NA	NA
WP_037598503.1\|1201953_1203153_+	argininosuccinate synthase	NA	NA	NA	NA
WP_037601513.1\|1203479_1204865_+	argininosuccinate lyase	NA	NA	NA	NA
WP_037600055.1\|1204949_1205285_+	ribonuclease P protein component	NA	NA	NA	NA
WP_070576655.1\|1205400_1206207_+	membrane protein insertase YidC	NA	NA	NA	NA
WP_070576653.1\|1206218_1207262_+	protein jag	NA	NA	NA	NA
WP_070576650.1\|1207391_1207988_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_070576647.1\|1207984_1208548_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_002885866.1\|1208743_1208878_+	50S ribosomal protein L34	NA	NA	NA	NA
WP_070576644.1\|1209082_1210225_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	3.2e-85	42.8

DBSCAN-SWA_7

1522571 : 1532814

Streptococcus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002891518.1\|1522571_1523471_+	SPFH domain-containing protein	A0A1V0SL90	Klosneuvirus	1.8e-35	32.8
WP_080611862.1\|1523514_1523910_-	lactoylglutathione lyase	NA	NA	NA	NA
WP_080611863.1\|1524025_1524919_+	ROK family protein	NA	NA	NA	NA
WP_060972239.1\|1525073_1526168_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.9e-172	81.5
WP_080611864.1\|1526180_1526738_+	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	5.4e-54	56.7
WP_080611865.1\|1526756_1527935_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	3.0e-179	79.8
WP_080611866.1\|1527989_1528484_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.3e-35	45.1
WP_037598335.1\|1528518_1528872_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	4.1e-39	65.8
WP_037598332.1\|1529152_1529527_+	CidA/LrgA family protein	NA	NA	NA	NA
WP_070576758.1\|1529519_1530215_+	LrgB family protein	NA	NA	NA	NA
WP_070576761.1\|1530300_1530861_+	HAD-IA family hydrolase	NA	NA	NA	NA
WP_002891505.1\|1530861_1532814_+	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	7.5e-143	45.4

DBSCAN-SWA_8

1731535 : 1824572

Streptococcus_phage(90.0%)

integrase,transposase,bacteriocin,protease

attL 1785636:1785655|attR 1816753:1816772

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060972274.1\|1731535_1732294_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_060972266.1\|1732376_1733252_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_060972265.1\|1733392_1733743_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_060972264.1\|1734093_1735719_+	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_060972263.1\|1735796_1736744_+	AEC family transporter	NA	NA	NA	NA
WP_080611903.1\|1737609_1738620_+	hypothetical protein	NA	NA	NA	NA
WP_192573911.1\|1738731_1738875_-	hypothetical protein	NA	NA	NA	NA
WP_080611904.1\|1739209_1748605_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_080611905.1\|1748868_1751394_-	glucosyl transferase	NA	NA	NA	NA
WP_080611906.1\|1751776_1754653_-	glucosyl transferase	NA	NA	NA	NA
WP_080610693.1\|1754919_1757160_-	glucosyl transferase	NA	NA	NA	NA
WP_105257722.1\|1757458_1760551_-	hypothetical protein	NA	NA	NA	NA
WP_080611907.1\|1760833_1762792_-	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_037597995.1\|1763106_1766376_-	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_021151642.1\|1766706_1767579_+	pyridoxal 5'-phosphate synthase lyase subunit PdxS	NA	NA	NA	NA
WP_070576982.1\|1767579_1768173_+	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	NA	NA	NA	NA
WP_176744108.1\|1768432_1770880_-	glucosyl transferase	NA	NA	NA	NA
WP_080611908.1\|1771595_1774124_-	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_080611909.1\|1774178_1777742_-	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_080611910.1\|1777799_1780271_-	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_037602276.1\|1780327_1783183_-	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_080611911.1\|1784195_1788902_+	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
1785636:1785655	attL	NA	NA	NA	NA
WP_049545415.1\|1789382_1791359_+	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_000420682.1\|1792338_1792653_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000985015.1\|1792668_1793055_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000813488.1\|1793083_1794469_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000879507.1\|1794471_1794624_+	hypothetical protein	NA	NA	NA	NA
WP_000398284.1\|1794646_1795852_+	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_001009056.1\|1795894_1796116_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|1796232_1796730_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|1796704_1797211_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331160.1\|1797194_1799642_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000804748.1\|1799644_1801822_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_000769868.1\|1801818_1802820_+	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_001224319.1\|1802816_1803749_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	1.1e-171	100.0
WP_001791010.1\|1803993_1804110_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_000691727.1\|1804125_1806045_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	100.0
WP_000336323.1\|1806163_1806331_+	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_001814874.1\|1806943_1807027_+	23S rRNA methyltransferase attenuation leader peptide	NA	NA	NA	NA
WP_001038790.1\|1807151_1807889_+	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	E4ZFQ0	Streptococcus_phage	1.4e-134	99.6
WP_000576156.1\|1808243_1808798_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	2.3e-36	52.1
WP_001240982.1\|1808801_1811720_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.1e-169	36.1
WP_000804885.1\|1812519_1812942_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|1812938_1813169_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000814511.1\|1813629_1813833_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_001291561.1\|1813914_1815132_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_080611912.1\|1815531_1820271_+	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
1816753:1816772	attR	NA	NA	NA	NA
WP_021143892.1\|1820543_1820870_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_080611913.1\|1821071_1821809_+\|protease	YhfC family intramembrane metalloprotease	NA	NA	NA	NA
WP_045768468.1\|1821795_1822071_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_037601131.1\|1822060_1822648_+	DUF1648 domain-containing protein	NA	NA	NA	NA
WP_080611914.1\|1822695_1823733_-	LD-carboxypeptidase	NA	NA	NA	NA
WP_021151650.1\|1824242_1824572_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA

DBSCAN-SWA_9

2047027 : 2057690

Streptococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002891089.1\|2047027_2048836_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	A7IW18	Paramecium_bursaria_Chlorella_virus	2.5e-100	39.4
WP_002891088.1\|2048950_2049283_+	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_014634576.1\|2049483_2050125_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002891086.1\|2050133_2050763_+	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.8e-32	40.2
WP_060971242.1\|2050775_2051627_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_080611993.1\|2051740_2053156_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	6.1e-195	70.7
WP_014634573.1\|2053152_2053530_+	hypothetical protein	A0A1B0RXA8	Streptococcus_phage	9.1e-21	45.8
WP_037611375.1\|2053507_2053789_+	hypothetical protein	M1PG86	Streptococcus_phage	1.6e-22	58.4
WP_014634571.1\|2053950_2054970_+	alcohol dehydrogenase AdhP	A0A2K9L339	Tupanvirus	1.3e-26	25.2
WP_002891076.1\|2055253_2055838_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014634570.1\|2056127_2057690_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.4e-19	30.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP020451

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection