CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP014175	Clostridium argentinense strain 89G plasmid pRSJ17_1, complete sequence	0 crisprs	cas14k,cas6	0	0	1	0
NZ_CP014176	Clostridium argentinense strain 89G chromosome, complete genome	7 crisprs	WYL,csa3,cas3,cas14j,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,DEDDh,DinG,c2c10_CAS-V-U3	1	12	7	1

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

99401 : 110404

Clostridium_botulinum_phage(33.33%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039635753.1\|99401_102998_-	non-toxic nonhemagglutinin NTNH	Q332E1	Clostridium_botulinum_C_phage	0.0e+00	65.9
WP_039635751.1\|103175_103712_-	botulinum neurotoxin transcription-activating sigma factor BotR	Q38195	Clostridium_botulinum_phage	2.7e-34	45.6
WP_039635749.1\|104116_104560_+	hemagglutinin	Q786Y1	Clostridium_botulinum_D_phage	4.2e-33	51.3
WP_039635747.1\|104593_106483_+	botulinum neurotoxin hemagglutinin HA70 subunit	Q786X9	Clostridium_botulinum_D_phage	3.6e-219	63.8
WP_039635745.1\|106553_107411_+	ricin-type beta-trefoil lectin domain protein	Q38196	Clostridium_botulinum_phage	1.2e-76	51.4
WP_080618818.1\|107791_107980_-\|transposase	transposase	NA	NA	NA	NA
WP_039635743.1\|108258_108555_-	hypothetical protein	NA	NA	NA	NA
WP_039635740.1\|109078_110404_-	hypothetical protein	Q858S9	Enterobacteria_phage	1.6e-24	22.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP014176

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014176_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_1

1721180-1721661

TypeV

III-B

Consensus_repeat	Method
CTTAACATAGGATGTATTTAAAT	CRISPRCasFinder

7 spacers

The CRISPR arrays of NZ_CP014176_1

>merge|NZ_CP014176|1|1721180-1721661|CRISPRCasFinder
TTTAACATAGGATGCATTTGAATAAAAAAGACTCTGACATTTTTAGGGTGTTAACTGTGTTGAACCTTAACATGGGATGTATTTAAATAAATATGATTTTACTCTATTTTGATTACAGTAACTAAGTTGAACCTTAACATAGGATGCATTTAAATTCTTGAAGCATATTTTGTATTTCAGATATATCATTTGTTGAACTTTAACATGAGATGTATTTAAATAATCCAATTCTATTAAATTTGATATCTTGTTCTGTAGTTGAACCTTAACATGAGATGTATTCAAATTCTGTATAGTCTTTAAGTTTTAGACTTTCGGCACCGTTGAACCTTAACATAGGATGTATTTAAATGACGCATTTCTAAACTCTGCATCCAATACTCTAATTGTTGAATCGTAACATAGGATGTATTTAAATTTGAATACTACTTTTTCATTTATAAGAGGAAGAAGTTGAACCTTAACATGGGATGTATAAACAA

>NZ_CP014176|1|1|1721180-1721661|CRISPRCasFinder
TTTAACATAGGATGCATTTGAAT	AAAAAAGACTCTGACATTTTTAGGGTGTTAACTGTGTTGAAC
CTTAACATGGGATGTATTTAAAT	AAATATGATTTTACTCTATTTTGATTACAGTAACTAAGTTGAAC
CTTAACATAGGATGCATTTAAAT	TCTTGAAGCATATTTTGTATTTCAGATATATCATTTGTTGAAC
TTTAACATGAGATGTATTTAAAT	AATCCAATTCTATTAAATTTGATATCTTGTTCTGTAGTTGAAC
CTTAACATGAGATGTATTCAAAT	TCTGTATAGTCTTTAAGTTTTAGACTTTCGGCACCGTTGAAC
CTTAACATAGGATGTATTTAAAT	GACGCATTTCTAAACTCTGCATCCAATACTCTAATTGTTGAAT
CGTAACATAGGATGTATTTAAAT	TTGAATACTACTTTTTCATTTATAAGAGGAAGAAGTTGAAC
CTTAACATGGGATGTATAAACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039631297.1\|1716387_1716627_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|225753
NZ_CP014176.1\|WP_039631295.1\|1715161_1716244_+\|Ig-domain-containing-protein	unknown	unknown	gnl\|CDD\|227779
NZ_CP014176.1\|WP_039631317.1\|1730293_1731133_-\|response-regulator	unknown	unknown	gnl\|CDD\|378022
NZ_CP014176.1\|WP_039631291.1\|1712139_1712790_+\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NZ_CP014176.1\|WP_039631321.1\|1732822_1734592_+\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|341070
NZ_CP014176.1\|WP_039631307.1\|1723877_1724579_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP014176.1\|WP_039631313.1\|1727936_1728344_+\|DUF3785-family-protein	unknown	unknown	gnl\|CDD\|372240
NZ_CP014176.1\|WP_052268008.1\|1717132_1717333_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_080618908.1\|1731135_1732431_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|214643
NZ_CP014176.1\|WP_039631302.1\|1720135_1721071_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_052268009.1\|1718480_1719155_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP014176.1\|WP_039631315.1\|1728669_1729698_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|379113
NZ_CP014176.1\|WP_039631311.1\|1726079_1727444_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039631305.1\|1722662_1723220_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039631293.1\|1713269_1714010_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234640
NZ_CP014176.1\|WP_052268007.1\|1714142_1714775_+\|phage-integrase-N-terminal-SAM-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|274042
NZ_CP014176.1\|WP_039631309.1\|1724583_1725990_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP014176.1\|WP_039631299.1\|1717437_1717764_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039631301.1\|1719294_1719597_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039631323.1\|1734679_1735315_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039631297.1\|1716387_1716627_+\|PepSY-domain-containing-protein	gnl\|CDD\|225753	COG3212, COG3212, Predicted membrane protein [Function unknown].	3.1836e-09
NZ_CP014176.1\|WP_039631295.1\|1715161_1716244_+\|Ig-domain-containing-protein	gnl\|CDD\|227779	COG5492, COG5492, Bacterial surface proteins containing Ig-like domains [Cell motility and secretion].	1.31192e-18
NZ_CP014176.1\|WP_039631317.1\|1730293_1731133_-\|response-regulator	gnl\|CDD\|378022	pfam08664, YcbB, YcbB domain. YcbB is a DNA-binding domain.	2.77458e-41
NZ_CP014176.1\|WP_039631291.1\|1712139_1712790_+\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	4.3306e-66
NZ_CP014176.1\|WP_039631321.1\|1732822_1734592_+\|M3-family-oligoendopeptidase	gnl\|CDD\|341070	cd09607, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B Oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and is similar to oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NZ_CP014176.1\|WP_039631307.1\|1723877_1724579_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.54034e-81
NZ_CP014176.1\|WP_039631313.1\|1727936_1728344_+\|DUF3785-family-protein	gnl\|CDD\|372240	pfam12653, DUF3785, Protein of unknown function (DUF3785). This family of proteins is functionally uncharacterized.This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. These proteins share two CXXC motifs suggesting these are zinc binding proteins. This protein is found in clostridia in an operon with three signalling proteins, suggesting this protein may be a DNA-binding transcription regulator downstream of an as yet unknown signalling pathway (Bateman A pers obs).	7.12436e-38
NZ_CP014176.1\|WP_080618908.1\|1731135_1732431_-\|ATP-binding-protein	gnl\|CDD\|214643	smart00387, HATPase_c, Histidine kinase-like ATPases. Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.	1.80418e-19
NZ_CP014176.1\|WP_052268009.1\|1718480_1719155_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	1.11826e-39
NZ_CP014176.1\|WP_039631315.1\|1728669_1729698_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|379113	pfam13303, PTS_EIIC_2, Phosphotransferase system, EIIC. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.	1.73107e-51
NZ_CP014176.1\|WP_039631293.1\|1713269_1714010_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	1.26414e-152
NZ_CP014176.1\|WP_052268007.1\|1714142_1714775_+\|phage-integrase-N-terminal-SAM-like-domain-containing-protein	gnl\|CDD\|274042	TIGR02224, Tyrosine_recombinase_XerC, tyrosine recombinase XerC. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	1.02459e-24
NZ_CP014176.1\|WP_039631309.1\|1724583_1725990_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.22641e-39

>NZ_CP014176.1|WP_039631302.1|1720135_1721071_+|hypothetical-protein
MGNIITRKYIGLPEEYWHKQNFCWYMHDANNTLGIEIFNAILADMCNFIYESLNTIENGKITVSLALLRKPFRDNLLYLEWLLADPKEFINMVNNQDIEKYAIEKISKDKKINIIKSAIEKLDNQEYFSSMDEIFYYDLRYNYKPEYSLQRVWNKASHLVTTGNHIKSNEFNFIFSGQEDDLDLIDCYYNQVPHLLFYTYNIVIKLYNTFIRETSDATKIYNNHLILYKFCDLIDTVIPQDYFNEEMKILLSFPCENCKKIIRIDLFSNEFNGFRNGWGFTCPECGSDVGTCKYIFWEDYKEKNMHLKIVK
>NZ_CP014176.1|WP_039631301.1|1719294_1719597_-|hypothetical-protein
MRFNYEITESFRNEVEKTIKAYEKNGIVTRHDVATMDSHFGARRLYDALLEYGYDKAIIQEVFLPNRLDYSGVIFNIEEYSYEKTEEYMFNYVLSDEEFR
>NZ_CP014176.1|WP_052268009.1|1718480_1719155_+|N-acetylmuramoyl-L-alanine-amidase
MKIGIDCGHTLSGADYGAVGVKAESVLTREVGSRVINKLKALGHNVINRTIDNSNSLEESLAYRVNQANNNDVDLFVSIHFNAYNGLAYGTEVFTWGAEQLPEATRVLNNLVGIGYANRGIKDGSNLYVIRNTKAKAMLIELFFIDSIDVELYKKVGSERLANAIVEGITGKAMPNNGNWYSLDGKLGVVTAKDGLNVRQSKSTNSKILGILKHGEKVRFKGSS
>NZ_CP014176.1|WP_039631299.1|1717437_1717764_+|hypothetical-protein
MNGIFIGNFYHCMPSEMADKDGKRAIINYYCFGPIEVVIYGVTSMNEYYLDYTYPEFWGDAELEHEHNIITKKEMLKVIDSQIELCERNGGTNIAKALRSEKKLIEES
>NZ_CP014176.1|WP_052268008.1|1717132_1717333_+|hypothetical-protein
MIADYYGIDILEYYRTEKIIQGERAHHIIELSKDWNSRLDVSNLIYLTEQNHRLYWERLCKNYSRL
>NZ_CP014176.1|WP_039631297.1|1716387_1716627_+|PepSY-domain-containing-protein
MRDIYYRLWDDYWRTYRINSEAAIQIASERVPGRVEKVRIDYKNNLLIYEVDIRNDTGLYKVEVNADTGKILKIERKSD
>NZ_CP014176.1|WP_039631295.1|1715161_1716244_+|Ig-domain-containing-protein
MKRKLKSILILMFAFVFMSLSFSNAKIVKAASLNGAVIGTENLNNTPENSAKIGDKLNLPEKEWKRYDDDNKQIEYTGIWTYKNNATGAYLNTDHFSNDSNAQIKFNFYGSKLRLIASTNNNRSEKNIITIDGISHEYTELLSDSWEEVKLIFEIKDLTLGEHSVTIGKSEINDKYMVLDAIDIDANGELLPYEIKTESISLDKSSIDLEVGQTDKLTATVLPEDAVNKKVVWSSSDETIATVDQEGNVTAIKEGQATITAKVENTDLTATCEVNVSKLAEENKNNAILSISLVNGATKEYDVSMEEVNKFINWYEERANGKGSALYSFDKKLNPYTSVKEYIVHDKIVSFQVREYEISK
>NZ_CP014176.1|WP_052268007.1|1714142_1714775_+|phage-integrase-N-terminal-SAM-like-domain-containing-protein
MELNDVLKEFIFDCEVKNYSEKTIKGYRNNNILFFNYLNKEFNITELESIKSMHIKKYFKFLMQKRCKPTYANAVLKTVRAFFKYCMEEEYLEENPCLKVGWQKEGKVIINTFTDTEIVNMLEVYKFTTYLEARNKMLIAFLIDTGARNNETCTLLKDDIKDKTIMLRGKGNKERQVSVSPLLKKYMMRLRKCIIQNDYLSEIKIILVVY
>NZ_CP014176.1|WP_039631293.1|1713269_1714010_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHSKWHNIQAKKGKVDAKRGKIFTKIGKELMVAAKNGGANPETNNKLRDVIAKAKAANMPSDTITRAIKKAAGELEGVSYEEITYEGYGAAGVAVIVETLTDNKNRTAGNVRHAFSKHGGNMGSTGCVSFMFQKKGEIVIEKNGDLDEDELMMMALEAGAEDFASEDEVYVVTTTPEDFGAVRESLEENGVEFLEAEVKLVADTNSEVDMETAGKIQKMLDALEDDDDVQNVYHNAEFPEGFEE
>NZ_CP014176.1|WP_039631291.1|1712139_1712790_+|YigZ-family-protein
MSYFTIKDEASAEFEERKSVFIGYAKRVKTEEEAKEFVAKIKAMHKQATHNCSAYIVGENKGIQRYSDDGEPQGTAGIPILEVIKKNDLTDIAVVVTRYFGGILLGAGGLVRAYSKGASEAIKVGGIVEKVKGLEIKVKLDYDLLGKIQYICGKNQWHIEDTMYTDKVEIIMYCESKKYDTIHGSFVEATNGKVIISEEEEEYYFKMENRLFKEVI
>NZ_CP014176.1|WP_039631305.1|1722662_1723220_+|hypothetical-protein
MGCYIKGFFILLVIGLIVKYPIPFIVMVVALIYFIFKPEKKSVIEEKEIKETYKIPEETFKLHIIDFKYGNEVIANRDFQVWLDGKELCFFGNVSPENLKIKQYIKIKIPTKNINFFTRIGDIYTKGKDREVVDNRETVMEVIDDKNEITYLRFDSDAYEIFVTLVINKEKSLVSLRKTTSGQCK
>NZ_CP014176.1|WP_039631307.1|1723877_1724579_+|response-regulator-transcription-factor
MVNKNKILIIEDEKSIIDIMCYSLRKEGMEVIYGLNGREGMTLVESFKPDLIILDLMLPDIDGFEICKIITVKYKIPILMVTARDDIMDKVLGLEMGADDYITKPFNIREVVARVKVALRRIENFNNNYIEKYQEKDIIVSENIVIIPKSRIVKKNGEEIKLKPREYDLLLLFSENKGRVFSRETLLDSVWTMDYDGDIRTVDVHVQRLRKKLDDKNNPSIIETIFGVGYKMR
>NZ_CP014176.1|WP_039631309.1|1724583_1725990_+|HAMP-domain-containing-histidine-kinase
MKLKYKFLIGFLAVFSIAFYILNFFISKNIEKNNKVILSKEMRILYQNSQSYITQYFVLNSIEISEKGFKDNTTDIIVELSDKNNCNVSLYDKDGNILNSSYGGEDVTVFPNFKEDVILGSNEDLNMAKQDKLSFLVNNIENKIIVNLSYPLYINKNFLGIVRFSKDYTYLYEGNNNLLNIVRIIVVITFIIIFIFSYLLSIKITNPIMKLSEASREVAKGNYDVEISIKSQDEIGKLSEDFINMKDKIKSQIETLKEIQAYRKKFFDNVTHELKTPLTTISGYAEILSEEEFSDDEFSKKAINHIKDESGRLEKMVIELLEISKLDSFDHKKIEVERFNFSNLLEDLCYHMSFKANKYNMDIEDHVQDNIYIYGDESKLKQVIINLLDNSIKYGKSNSTIEVKANIIDNYCEIDIKNKLTDNEEKEEGSRGLGIYICKNIIELHKGIFTIEDINNEFKLVKFKIPLN
>NZ_CP014176.1|WP_039631311.1|1726079_1727444_+|hypothetical-protein
MKSSKKLVKDRIIILLSTIMVFLSGCGTQLKDNAIILEENLSQISQEGYQLEITKKLMKEKEIFDVEFWDYIYEPLYGVAPEEVKRNGDMVKLKLFGEELDVLNMEGKDGPYHLQTQSNDRKNIYFNATSDREGIYKVRVDNMKKVESVITLPKKEDFICNFNVLKDGNIIFRGIYNESIGIFYYNASKNSINKLIAGGRNEKGTWIPIYNLSPGENKIIYYQLKDSTGNVNIYGGTFNEGKIEDATIIEEHIVPVISGYIKDGRNVIKGRNLIGASFIAWNNEKTAMISIPSKVSSEYSCKEKVYQVTLENEQDKIDKAARKFINKFYTVGSKEYDLMRTLGNNSKNKKEVAKLIEDSLASCMTSDARLTLINDMKYINRLDEYISKKDTLSVYDIALEKTEKNNGYVTYNYKIKLWKKSSDNKDEVKEISKSICLEQENNQWKVNNYTKFTY
>NZ_CP014176.1|WP_039631313.1|1727936_1728344_+|DUF3785-family-protein
MKYKFNFENREYELKEDNLEYIYDENIEGFEYETLIELLNNSDKVSFDLEYFDGRCDVCEAGKGEGRKHYDFLEYHFFVFTKNNKYIISTISKDYEEGIYTDLYKRKVIDNDFIVSIIVCKECGAWMVEIEQCDM
>NZ_CP014176.1|WP_039631315.1|1728669_1729698_-|PTS-sugar-transporter-subunit-IIC
MLTIIKGIGLLIFTLALFSLFSLKMPKGQKAMSGLANAAVATFLVEAIHKYISGDLLNISFLSTVGSSSGSMGGVAAVILVGISMGINPIYAVVAGVAVSGYGILPGFIAGYIVGLIAPYIEKKLPEGLDVIVGALLIAPIARGIALGVDPVVNATLINIGEMISIAAEQSPYLMGFLLGGIMKMICTSPLSSMALTAMLDLKGLAMGIASIACVGGSFTNGMIFHKLKLGNKSNVVAVMLEPLTQAHIVTANAIPIYVSNFFGGGLSGLAAAHFKIINNAPGTASPIPGLLAPFGFNNPLNVVLAVGLSVLGGLLAGEIGSRVFKKQAKAPQNINTINEVA
>NZ_CP014176.1|WP_039631317.1|1730293_1731133_-|response-regulator
MRFFLIDDDISIINILKLIIEDRNLGKVIGYATNGIDGFEDIKELKPDVVIVDLLMPYKDGITIVKSCKESNLKINFIMLSQVTSKDMIAKAYENGIEFYIQKPVNAIEVENVIKKVTENINMNRTLGKIQDLFIAETSVNIKTPKKDNTYINKLKNILQKLGIMGELGSKDIILIIEYLQKHNETISDYTLRELCSKFTDNPKSMEQRIRRAATVGMINIANLGLEDYMNETFIEYSNGLYNFEQIKKEMDCIRGKTNIHGKINIKKFINGIIFYSER
>NZ_CP014176.1|WP_080618908.1|1731135_1732431_-|ATP-binding-protein
MYINDLTNNKTEKLKKSIIASTFVSIAAQMHINLLLTNFKISIAIILFPIFLYIFEDLDIIITTIFSAFGVYFLRVLVHFVNTGVYQDILYAYFPEIFFYLSYGILFSFYKKFNSKFKIKKIFISFVIIDYLANLVEITIRLGPGIFDFKIQQGIFFVAIIRSFLIWVLLTSLDYYGIFLLKNEHEQRYKKLLWVTSKLRTEIFWMEKNMYHIESTMTTSYKLFEKITDNEDSETWADSALTIAKDIHEIKKEYSLVVRGVKEALEDKLNDNGIYFKDIMKILKESMEKEVEFLDKDIKLYFYFERDFFTKKHYYLMSIFRNIIMNAIEAIKDKDKSNSIWFKHTENEMYHIFKIKDTGSGIKDEHLSLIFSPGFSTKINYTTGEINRGLGLSLVKDIITNALQGEIEVNSIIEEGTTFIIRIPKNVLEEI
>NZ_CP014176.1|WP_039631321.1|1732822_1734592_+|M3-family-oligoendopeptidase
MEHKWSLKELYDSFESIVFKEDMAKLEDYIHSFKDFGNQLSCSGNLKKTLEEYISLYKNMTTLFNKLFSYASLTISVDTKNEIALKNLEILENKYSETAEPLAKINKFIGSIENLQHIIEDSQLLKEHEYYLNEISKRSKYLLSDKEEGIIAKMSNSGSSAWNKMMELLVSNLKVDIEEEGEIKQLPLSVVRNLAYDKNKDIRKKAYEAEVKGYEKIEDAVAASLNGIKGEVITVCKLRGFGSPLEETLFNSRMDKETLDAMISAMKESLPIFRKYLKRKAELLGYENGLPFYELFAPMGNVDMKFEYEKGKVFVEDNFRTFSDKLADFARKAFDNNWIDVYPREGKVGGAFCAGLHMLGESRLMLNYGNTFSDVVTLAHELGHGYHGECLKEESILNSDYPMPIAETASTFCETIIKKAAIKTASKEEAFSILEAEISDSTQVIVDILSRYIFETNLFNRREESSLSSTELKELMINAQLEAYGDGLDKEYLHPYMWLCKGHYYSAGLSFYNFPYAFGLLFAKGLYADYLKRGEEFIKEYDKLLSLTGKMDIADLTKLMNIDVHSIDFWRSSLKVIEEDIEKFIELSK
>NZ_CP014176.1|WP_039631323.1|1734679_1735315_+|hypothetical-protein
MFKKFLKNKKILTYILGGIIIFLSSYFVYTNILSKENVYSLAKEASSTNSKPLKFNSKNKIEFFIKYSNCKDFIEDTQMNEMVERDKDKLNGLKEAELEEIYKSYGYKLEKFTKDQVIFIKEIEGYNYEADNYFIGIGENNVVIYNKKQDGNITIEEPLIKNVRSEEDKAITLDYIKDKGNLMESLYKGKKEYQFKTKEEAIEYAQALCSS

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Crispr_ID: NZ_CP014176_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_2

2130959-2135190

Unclear

Consensus_repeat	Method
GTTTTATATTAACTATGAGGTATATAAAG	PILER-CR
GTTTTATATTAACTATGAGGTATATAAAG	CRISPRCasFinder
GTTTTANATTAACTATGAGGTATATAAAG	CRT
GTTTTACATTAACTATGAGGTATATAAA	PILER-CR
GTTTTANATTAACTATGAGGTATATAAAG	CRT
GTTTTACATTAACTATGAGGTATATAAA	PILER-CR
GTTTTACATTAACTATGAGGTATATAAAG	PILER-CR

64 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,WYL

The CRISPR arrays of NZ_CP014176_2

>merge|NZ_CP014176|2|2130959-2135190|PILER-CR,CRISPRCasFinder,CRT,PILER-CR,CRT,PILER-CR,PILER-CR
GTTTTATATTAACTATGAGGTATATAAAGTATTCTTTATAGCTTTATCACAATACTGCTCAATATCGTTTTATATTAACTATGAGGTATATAAAGAAAGTATAAGCTAAATCTTCATATCTTTTACGTAAAGTTTTATATTAACTATGAGGTATATAAAGGAAACAATAAAGTTTTATGGTACTAACACTTATAAAGTTTTATATTAACTATGAGGTATATAAAGTTTACAGGCGACTTTGCATATTTCTATGAAGAAATAGGTTTTATATTAACTATGAGGTATATAAAGTAGAGATATTGAAATTAGTAGATTGTAAATAAATAGAGTTTTATATTAACTATGAGGTATATAAAGTAGATTGGACACAACAAAATGTAATGCCACAAGTACGTTTTATATTAACTATGAGGTATATAAAGATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGCGTTTTATATTAACTATGAGGTATATAAAGTTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTGGTTTTATATTAACTATGAGGTATATAAAGACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCATGTTTTATATTAACTATGAGGTATATAAAGTTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAACGTTTTATATTAACTATGAGGTATATAAAGGCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTGGTTTTATATTAACTATGAGGTATATAAAGTTGAAGACATTGGGTCAATGAAGTTATACCACAAGAGTTTTATATTAACTATGAGGTATATAAAGTATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAAGTTTTATATTAACTATGAGGTATATAAAGCAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATTGTTTTATATTAACTATGAGGTATATAAAGCACATCTACGGTTAATAGCCCAACAATAACAGTCAACGTTTTATATTAACTATGAGGTATATAAAGAAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCACGTTTTATATTAACTATGAGGTATATAAAGGATTTACCCGTTCCAGTGTCCCCATCAATCAATAGAGTTTTACATTAACTATAAGGTATATAAAGTTAAAGAAATAACATACATATTCAACTTCCTTATTAGTTTTACATTAACTATGTGGTATATAAAGAGCACAAGGAACGCATGAAGAAGTGCTATGCATGGTTTTATATTAACTATGAGGCATATAAAGGACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTTATTTTATATTAACTATGAGGTATATAAACACAATTTGGTGTCATGCATATGGCTATAAAAAATAGTTTTACATTAACTATGAGGTATATAAAGTAGAATAAGATCTAATACCTTCCTCTTGCCTACAATGTTTTACATTAACTATGAGGGATATAAAGTTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGTGTTTTACATTAACTATGAGGGATATAAATTAGTATAATTTGTAGCAATAAGAAAATTATACTAAAGTTTAACATTAACTATGAGGTATATAAAGTGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTTGTTTTACATTAACTATGTGGTATATAAAGTGTTATGATAGAAGTAGTAGCAGATTAACATATTGGTTTTACATTAACTATGAAGTATATCAATGAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTAGTTTTACATTAACTATGAAGTATATCAATGGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATCGTTTTATATTAACTATATGGTATATAAAGATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATTGTTTTACATTAACTAAGAGGTATATAAATCAAATTATTGCTATATTACAAGCTTGGGTTTCTGCGCTTTACATTAACTATAAGGTATATAAAGTATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCTGGTTTTACATTACTATGAGGTATATAAAGCCGAACAAAACCACACTCTTCGTGCTAGGCATAAAGGTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAGGGCTTTAATACTCAGAATATGAGTCTAATTTTTGTTTTATATATAACTATGAGGTATATAAATTATGAAGTAGTATGTTTTTTCGATAGAGACGGTAATGTTTTATATTAACTATGTGGTATATAAAGATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAAGTTTTACATTAACTATGGAGTATATCAATGGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATCGTTTTATATTAACTATATGGTATATAAATATCATAAAATGATCTCTTTTAAATAAAAAACTATCTGGTTTTACATTAACTATGAGATATATAAAGGATGCTCCAAAGATAATATCTGTTGAGCAAGATAAAGTTTTATATTAACTATGAGGTATATAAATTGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGGGTCTTACATTAACTATGAGGCATATAAAGATAAGTAAAGAGTATACATATAGGATATTAAAAGAGTTTTGCATTAACTATGTGGTATATAAAGAGTGGAAAATCATGATTGATATTTATAACCCTAAAAGTTTTACATTAACGATGAGGTATATAAAGGTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAAGCTTTACATTAACTATGAGGTATATAAAGATACAATTTTGTATTTTTTTGTTAAAATGTGTACAGGTTTTAGATTAACTATAAGTTATATAAAGTGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTTGTTTTACATTGACCATGTGGTATATAAAGATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACAGTTCTACATTAACTATGAGGTATATAAAGGAAGAGGATATAAGGGGATACTTAGCAACAAAAGAGTTTTATATTAACTATGAGGTATATAAAGGAGCGGAATTCGTTTAATTGGATTATAAATAATATAGTTTTATATTAACTATGAGGTATATAAAGGACACGTTATTAACTGTATTAAATCTTTAATATTTGGTTTTATATTAACTATGAGGTATATAAAGCTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTTGTTTTATATTAACTATGAGGTATATAAAGAAGAAGAAAGATGGAATTTATGCAATAGTAATGGAAGTTTTGCATTAACTATGAGGTATATAAAGTAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCATGTTTTACATTAACTATGAGGCATATAAAGGCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGGGTTTTACATTAACTATGTGGTACATAAAGTATTATGCTAAAAAATATTAGAAGTAGAAAAAACATGTTTTACATTAACTATGAGGTACATAAAGAAGTAAACCCATCCTGCCCCGAAAAATAGTTCTACGGTTTTACATTAACAATGAGGTATATAAAGGAAAAGAGTAAGATGACTTGGAGTTTTGATAGAGTTGTCTTACATTAACTATGAGGTGTATAAGGAGTGCTGCTACTTTTTCTATAGTCCACCCCTTCTTTAGTTTTATATTAACTATGTGGTATATAAAGTTATGGATAGAAATGTTGGTAGAAGCAATGCACAATGTTTTACATTAACTACGAGGTATATAAAGTAGCTCTAATAATTTAAATCAGTAATAAGGTTTAAAGTTTTACATTAACTACGTGGTATATAAATGGTATTGAAAAAGAAGTAAACATACAAATAGGAGCAAGTTTTATATTAACTATGAGGTATATAAAGACTGTAATTAAAATCAAACAACAATTAGACCCCAAATGTTCTACATTAACTATGTGGTATATAAAGGTAAGAATTGATGAAGCTAATAATTCTATACAAGAGGTTTTGCATTAACTATTATGAGGTATATAAAGCAAAGAAAAAGAAAAGAAGCAGAGTAGTAATATCGGGTTTTACATTAACTATGAGGTATGCAAAGAAAAAATCCGTTATCATACACTTCATTGTCTACATTGTTATACATTAACTATGAAGCATATAAATCATTTATCCAGACATAGCTTTGCTACACATAAGTTAGTTTTATATTAACTATATGGTATATAAAG

>NZ_CP014176|2|1|2130959-2132420|PILER-CR
GTTTTATATTAACTATGAGGTATATAAAG	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAGTTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGTGTTTTACATTAACTATGAGGGATATAAA	TTAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAA	GTGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAA	GTGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAATGAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTAGTTTTACATTAACTATGAAGTATATCAATGGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATCGTTTTATATTAACTATATGGTATATAAAGATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATTGTTTTACATTAACTAAGAGGTATATAAATCAAATTATTGCTATATTACAAGCTTGGGTTTCTGCGCTTTACATTAACTATAAGGTATATAAAGTATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCTGGTTTTACATTACTATGAGGTATATAAAGCCGAACAAAACCACACTCTTCGTGCTAGGCATAAAGGTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAGGGCTTTAATACTCAGAATATGAGTCTAATTTTTGTTTTATATATAACTATGAGGTATATAAATTATGAAGTAGTATGTTTTTTCGATAGAGACGGTAATGTTTTATATTAACTATGTGGTATATAAAGATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAAGTTTTACATTAACTATGGAGTATATCAATGGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATCGTTTTATATTAACTATATGGTATATAAA	TATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAA	GGATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAA	TTGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAGATAAGTAAAGAGTATACATATAGGATATTAAAAGAGTTTTGCATTAACTATGTGGTATATAAAGAGTGGAAAATCATGATTGATATTTATAACCCTAAAAGTTTTACATTAACGATGAGGTATATAAAGGTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAAGCTTTACATTAACTATGAGGTATATAAAGATACAATTTTGTATTTTTTTGTTAAAATGTGTACAGGTTTTAGATTAACTATAAGTTATATAAAGTGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTTGTTTTACATTGACCATGTGGTATATAAAGATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACAGTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG


>NZ_CP014176|2|2|2130959-2135190|CRISPRCasFinder
GTTTTATATTAACTATGAGGTATATAAAG	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAG	TTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGT
GTTTTACATTAACTATGAGGGATATAAAT	TAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAAG	TGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAAG	TGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAAT	GAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTA
GTTTTACATTAACTATGAAGTATATCAAT	GGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATC
GTTTTATATTAACTATATGGTATATAAAG	ATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATT
GTTTTACATTAACTAAGAGGTATATAAAT	CAAATTATTGCTATATTACAAGCTTGGGTTTCTGC
GCTTTACATTAACTATAAGGTATATAAAG	TATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCT
GGTTTTACATTACTATGAGGTATATAAAG	CCGAACAAAACCACACTCTTCGTGCTAGGCATAAAG
GTTTTACATTAACTATGTGGGATATAAAT	CCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAGGGCTTTAATACTCAGAATATGAGTCTAATTTTTG
TTTTATATATAACTATGAGGTATATAAAT	TATGAAGTAGTATGTTTTTTCGATAGAGACGGTAAT
GTTTTATATTAACTATGTGGTATATAAAG	ATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAA
GTTTTACATTAACTATGGAGTATATCAAT	GGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATC
GTTTTATATTAACTATATGGTATATAAAT	ATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAAG	GATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAAT	TGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAG	ATAAGTAAAGAGTATACATATAGGATATTAAAAGA
GTTTTGCATTAACTATGTGGTATATAAAG	AGTGGAAAATCATGATTGATATTTATAACCCTAAAA
GTTTTACATTAACGATGAGGTATATAAAG	GTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAA
GCTTTACATTAACTATGAGGTATATAAAG	ATACAATTTTGTATTTTTTTGTTAAAATGTGTACAG
GTTTTAGATTAACTATAAGTTATATAAAG	TGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTT
GTTTTACATTGACCATGTGGTATATAAAG	ATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACA
GTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG
GTTTTACATTAACTATGTGGTACATAAAG	TATTATGCTAAAAAATATTAGAAGTAGAAAAAACAT
GTTTTACATTAACTATGAGGTACATAAAG	AAGTAAACCCATCCTGCCCCGAAAAATAGTTCTACG
GTTTTACATTAACAATGAGGTATATAAAG	GAAAAGAGTAAGATGACTTGGAGTTTTGATAGAGTT
GTCTTACATTAACTATGAGGTGTATAAGG	AGTGCTGCTACTTTTTCTATAGTCCACCCCTTCTTTA
GTTTTATATTAACTATGTGGTATATAAAG	TTATGGATAGAAATGTTGGTAGAAGCAATGCACAAT
GTTTTACATTAACTACGAGGTATATAAAG	TAGCTCTAATAATTTAAATCAGTAATAAGGTTTAAA
GTTTTACATTAACTACGTGGTATATAAAT	GGTATTGAAAAAGAAGTAAACATACAAATAGGAGCAA
GTTTTATATTAACTATGAGGTATATAAAG	ACTGTAATTAAAATCAAACAACAATTAGACCCCAAAT
GTTCTACATTAACTATGTGGTATATAAAG	GTAAGAATTGATGAAGCTAATAATTCTATACAAGAGGTT
TTGCATTAACTATTATGAGGTATATAAAG	CAAAGAAAAAGAAAAGAAGCAGAGTAGTAATATCGG
GTTTTACATTAACTATGAGGTATGCAAAG	AAAAAATCCGTTATCATACACTTCATTGTCTACATT
GTTATACATTAACTATGAAGCATATAAAT	CATTTATCCAGACATAGCTTTGCTACACATAAGTTA
GTTTTATATTAACTATATGGTATATAAAG

>NZ_CP014176|2|1|2130959-2133069|CRT
GTTTTATATTAACTATGAGGTATATAAAG	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAG	TTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGT
GTTTTACATTAACTATGAGGGATATAAAT	TAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAAG	TGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAAG	TGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAAT	GAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTA
GTTTTACATTAACTATGAAGTATATCAAT	GGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATC
GTTTTATATTAACTATATGGTATATAAAG	ATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATT
GTTTTACATTAACTAAGAGGTATATAAAT	CAAATTATTGCTATATTACAAGCTTGGGTTTCTGC
GCTTTACATTAACTATAAGGTATATAAAG	TATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCT
GGTTTTACATTACTATGAGGTATATAAAG	CCGAACAAAACCACACTCTTCGTGCTAGGCATAAAG
GTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAG	GGCTTTAATACTCAGAATATGAGTCTAATTTTTG
TTTTATATATAACTATGAGGTATATAAAT	TATGAAGTAGTATGTTTTTTCGATAGAGACGGTAAT
GTTTTATATTAACTATGTGGTATATAAAG	ATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAA
GTTTTACATTAACTATGGAGTATATCAAT	GGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATC
GTTTTATATTAACTATATGGTATATAAAT	ATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAAG	GATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAAT	TGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAG	ATAAGTAAAGAGTATACATATAGGATATTAAAAGA
GTTTTGCATTAACTATGTGGTATATAAAG	AGTGGAAAATCATGATTGATATTTATAACCCTAAAA
GTTTTACATTAACGATGAGGTATATAAAG	GTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAA
GCTTTACATTAACTATGAGGTATATAAAG	ATACAATTTTGTATTTTTTTGTTAAAATGTGTACAG
GTTTTAGATTAACTATAAGTTATATAAAG	TGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTT
GTTTTACATTGACCATGTGGTATATAAAG	ATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACA
GTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG
GTTTTACATTAACTATGTGGTACATAAAG	TATTATGCTAAAAAATATTAGAAGTAGAAAAAACAT
GTTTTACATTAACTATGAGGTACATAAAG	AAGTAAACCCATCCTGCCCCGAAAAATAGTTCTACG
GTTTTACATTAACAATGAGGTATATAAAG	GAAAAGAGTAAGATGACTTGGAGTTTTGATAGAGTT
GTCTTACATTAACTATGAGGTGTATAAGG	AGTGCTGCTACTTTTTCTATAGTCCACCCCTTCTTTA
GTTTTATATTAACTATGTGGTATATAAAG	TTATGGATAGAAATGTTGGTAGAAGCAATGCACAAT
GTTTTACATTAACTACGAGGTATATAAAG	TAGCTCTAATAATTTAAATCAGTAATAAGGTTTAAA
GTTTTACATTAACTACGTGGTATATAAAT	GGTATTGAAAAAGAAGTAAACATACAAATAGGAGCAA
GTTTTATATTAACTATGAGGTATATAAAG	ACTGTAATTAAAATCAAACAACAATTAGACCCCAAAT
GTTCTACATTAACTATGTGGTATATAAAG	GTAAGAATTGATGAAGCTAATAATTCTATACAAGAGGTT


>NZ_CP014176|2|2|2132457-2132678|PILER-CR
	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAGTTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGTGTTTTACATTAACTATGAGGGATATAAA	TTAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAA	GTGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAA	GTGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAATGAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTAGTTTTACATTAACTATGAAGTATATCAATGGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATCGTTTTATATTAACTATATGGTATATAAAGATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATTGTTTTACATTAACTAAGAGGTATATAAATCAAATTATTGCTATATTACAAGCTTGGGTTTCTGCGCTTTACATTAACTATAAGGTATATAAAGTATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCTGGTTTTACATTACTATGAGGTATATAAAGCCGAACAAAACCACACTCTTCGTGCTAGGCATAAAGGTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAGGGCTTTAATACTCAGAATATGAGTCTAATTTTTGTTTTATATATAACTATGAGGTATATAAATTATGAAGTAGTATGTTTTTTCGATAGAGACGGTAATGTTTTATATTAACTATGTGGTATATAAAGATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAAGTTTTACATTAACTATGGAGTATATCAATGGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATCGTTTTATATTAACTATATGGTATATAAA	TATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAA	GGATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAA	TTGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAGATAAGTAAAGAGTATACATATAGGATATTAAAAGAGTTTTGCATTAACTATGTGGTATATAAAGAGTGGAAAATCATGATTGATATTTATAACCCTAAAAGTTTTACATTAACGATGAGGTATATAAAGGTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAAGCTTTACATTAACTATGAGGTATATAAAGATACAATTTTGTATTTTTTTGTTAAAATGTGTACAGGTTTTAGATTAACTATAAGTTATATAAAGTGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTTGTTTTACATTGACCATGTGGTATATAAAGATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACAGTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG


>NZ_CP014176|2|2|2133079-2134995|CRT
	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAG	TTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGT
GTTTTACATTAACTATGAGGGATATAAAT	TAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAAG	TGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAAG	TGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAAT	GAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTA
GTTTTACATTAACTATGAAGTATATCAAT	GGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATC
GTTTTATATTAACTATATGGTATATAAAG	ATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATT
GTTTTACATTAACTAAGAGGTATATAAAT	CAAATTATTGCTATATTACAAGCTTGGGTTTCTGC
GCTTTACATTAACTATAAGGTATATAAAG	TATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCT
GGTTTTACATTACTATGAGGTATATAAAG	CCGAACAAAACCACACTCTTCGTGCTAGGCATAAAG
GTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAG	GGCTTTAATACTCAGAATATGAGTCTAATTTTTG
TTTTATATATAACTATGAGGTATATAAAT	TATGAAGTAGTATGTTTTTTCGATAGAGACGGTAAT
GTTTTATATTAACTATGTGGTATATAAAG	ATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAA
GTTTTACATTAACTATGGAGTATATCAAT	GGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATC
GTTTTATATTAACTATATGGTATATAAAT	ATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAAG	GATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAAT	TGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAG	ATAAGTAAAGAGTATACATATAGGATATTAAAAGA
GTTTTGCATTAACTATGTGGTATATAAAG	AGTGGAAAATCATGATTGATATTTATAACCCTAAAA
GTTTTACATTAACGATGAGGTATATAAAG	GTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAA
GCTTTACATTAACTATGAGGTATATAAAG	ATACAATTTTGTATTTTTTTGTTAAAATGTGTACAG
GTTTTAGATTAACTATAAGTTATATAAAG	TGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTT
GTTTTACATTGACCATGTGGTATATAAAG	ATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACA
GTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG
GTTTTACATTAACTATGTGGTACATAAAG	TATTATGCTAAAAAATATTAGAAGTAGAAAAAACAT
GTTTTACATTAACTATGAGGTACATAAAG	AAGTAAACCCATCCTGCCCCGAAAAATAGTTCTACG
GTTTTACATTAACAATGAGGTATATAAAG	GAAAAGAGTAAGATGACTTGGAGTTTTGATAGAGTT
GTCTTACATTAACTATGAGGTGTATAAGG	AGTGCTGCTACTTTTTCTATAGTCCACCCCTTCTTTA
GTTTTATATTAACTATGTGGTATATAAAG	TTATGGATAGAAATGTTGGTAGAAGCAATGCACAAT
GTTTTACATTAACTACGAGGTATATAAAG	TAGCTCTAATAATTTAAATCAGTAATAAGGTTTAAA
GTTTTACATTAACTACGTGGTATATAAAT	GGTATTGAAAAAGAAGTAAACATACAAATAGGAGCAA
GTTTTATATTAACTATGAGGTATATAAAG	ACTGTAATTAAAATCAAACAACAATTAGACCCCAAAT
GTTCTACATTAACTATGTGGTATATAAAG	GTAAGAATTGATGAAGCTAATAATTCTATACAAGAGGTT
TTGCATTAACTATTATGAGGTATATAAAG

>NZ_CP014176|2|3|2133338-2133562|PILER-CR
	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAGTTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGTGTTTTACATTAACTATGAGGGATATAAA	TTAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAA	GTGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAA	GTGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAATGAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTAGTTTTACATTAACTATGAAGTATATCAATGGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATCGTTTTATATTAACTATATGGTATATAAAGATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATTGTTTTACATTAACTAAGAGGTATATAAATCAAATTATTGCTATATTACAAGCTTGGGTTTCTGCGCTTTACATTAACTATAAGGTATATAAAGTATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCTGGTTTTACATTACTATGAGGTATATAAAGCCGAACAAAACCACACTCTTCGTGCTAGGCATAAAGGTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAGGGCTTTAATACTCAGAATATGAGTCTAATTTTTGTTTTATATATAACTATGAGGTATATAAATTATGAAGTAGTATGTTTTTTCGATAGAGACGGTAATGTTTTATATTAACTATGTGGTATATAAAGATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAAGTTTTACATTAACTATGGAGTATATCAATGGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATCGTTTTATATTAACTATATGGTATATAAA	TATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAA	GGATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAA	TTGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAGATAAGTAAAGAGTATACATATAGGATATTAAAAGAGTTTTGCATTAACTATGTGGTATATAAAGAGTGGAAAATCATGATTGATATTTATAACCCTAAAAGTTTTACATTAACGATGAGGTATATAAAGGTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAAGCTTTACATTAACTATGAGGTATATAAAGATACAATTTTGTATTTTTTTGTTAAAATGTGTACAGGTTTTAGATTAACTATAAGTTATATAAAGTGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTTGTTTTACATTGACCATGTGGTATATAAAGATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACAGTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG


>NZ_CP014176|2|4|2133924-2134404|PILER-CR
	TATTCTTTATAGCTTTATCACAATACTGCTCAATATC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGTATAAGCTAAATCTTCATATCTTTTACGTAAA
GTTTTATATTAACTATGAGGTATATAAAG	GAAACAATAAAGTTTTATGGTACTAACACTTATAAA
GTTTTATATTAACTATGAGGTATATAAAG	TTTACAGGCGACTTTGCATATTTCTATGAAGAAATAG
GTTTTATATTAACTATGAGGTATATAAAG	TAGAGATATTGAAATTAGTAGATTGTAAATAAATAGA
GTTTTATATTAACTATGAGGTATATAAAG	TAGATTGGACACAACAAAATGTAATGCCACAAGTAC
GTTTTATATTAACTATGAGGTATATAAAG	ATTGAAATAACGAAAGAAGAAGCAAAAGAAAAACGC
GTTTTATATTAACTATGAGGTATATAAAG	TTAGATGGAGAATGCGGGAGTGTTGAAGGAGAATTG
GTTTTATATTAACTATGAGGTATATAAAG	ACGAAAAACAAGAGCTAAGTAGAAGAATAGTTCCAT
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGTTTGTTTATATTCCTTTGCCAACCGAACAAC
GTTTTATATTAACTATGAGGTATATAAAG	GCTAGAACTGTAGTTGAATGGTTTATAGAACAGGCTG
GTTTTATATTAACTATGAGGTATATAAAG	TTGAAGACATTGGGTCAATGAAGTTATACCACAAGA
GTTTTATATTAACTATGAGGTATATAAAG	TATCATAGGCCTAAAACAAAAGAAGAAGCTTTAAA
GTTTTATATTAACTATGAGGTATATAAAG	CAGTTTGGAGAATAAAGGTAGAATGGCGGTATTATT
GTTTTATATTAACTATGAGGTATATAAAG	CACATCTACGGTTAATAGCCCAACAATAACAGTCAAC
GTTTTATATTAACTATGAGGTATATAAAG	AAAGAAATAAATTCTAAAGGTACTGTTAAAGTAGCAC
GTTTTATATTAACTATGAGGTATATAAAG	GATTTACCCGTTCCAGTGTCCCCATCAATCAATAGA
GTTTTACATTAACTATAAGGTATATAAAG	TTAAAGAAATAACATACATATTCAACTTCCTTATTA
GTTTTACATTAACTATGTGGTATATAAAG	AGCACAAGGAACGCATGAAGAAGTGCTATGCATG
GTTTTATATTAACTATGAGGCATATAAAG	GACACTAAGATTTTTCATAAGTGTTGTAGGTTCTTT
ATTTTATATTAACTATGAGGTATATAAAC	ACAATTTGGTGTCATGCATATGGCTATAAAAAATA
GTTTTACATTAACTATGAGGTATATAAAG	TAGAATAAGATCTAATACCTTCCTCTTGCCTACAAT
GTTTTACATTAACTATGAGGGATATAAAGTTCCCTAAAACTACGATACTAGTTTCCTTGTCTTGTGTTTTACATTAACTATGAGGGATATAAA	TTAGTATAATTTGTAGCAATAAGAAAATTATACTAAA
GTTTAACATTAACTATGAGGTATATAAA	GTGAAAACACTAGGCTTTGCCTAGTTCACCAAAGCTT
GTTTTACATTAACTATGTGGTATATAAA	GTGTTATGATAGAAGTAGTAGCAGATTAACATATTG
GTTTTACATTAACTATGAAGTATATCAATGAAGTTTGGGAGATAGTTAAAAAAGCTGTTTTGTTAGTTTTACATTAACTATGAAGTATATCAATGGTAGCAGTTCTGTAAAGTGCTTATATAAATCTATCGTTTTATATTAACTATATGGTATATAAAGATTCAAGAAAGAGTGCAAAATTGAAATAATAATTATTGTTTTACATTAACTAAGAGGTATATAAATCAAATTATTGCTATATTACAAGCTTGGGTTTCTGCGCTTTACATTAACTATAAGGTATATAAAGTATACGTGTTCAGAAGATGTTAATTTAGCCTTGGCTGGTTTTACATTACTATGAGGTATATAAAGCCGAACAAAACCACACTCTTCGTGCTAGGCATAAAGGTTTTACATTAACTATGTGGGATATAAATCCGAGTTAGGTTTTACATTAGCTATGAAGTATATAAAGGGCTTTAATACTCAGAATATGAGTCTAATTTTTGTTTTATATATAACTATGAGGTATATAAATTATGAAGTAGTATGTTTTTTCGATAGAGACGGTAATGTTTTATATTAACTATGTGGTATATAAAGATGTTATGTTGAATAAATCTGCGCTTGAAGACATTAAGTTTTACATTAACTATGGAGTATATCAATGGTAGCAATTCTGCAAAGTGCTTAGATAAATCTATCGTTTTATATTAACTATATGGTATATAAA	TATCATAAAATGATCTCTTTTAAATAAAAAACTATCTG
GTTTTACATTAACTATGAGATATATAAA	GGATGCTCCAAAGATAATATCTGTTGAGCAAGATAAA
GTTTTATATTAACTATGAGGTATATAAA	TTGGATTTGGGGAATAGGTGCTGCAACATATGCTGGGG
GTCTTACATTAACTATGAGGCATATAAAGATAAGTAAAGAGTATACATATAGGATATTAAAAGAGTTTTGCATTAACTATGTGGTATATAAAGAGTGGAAAATCATGATTGATATTTATAACCCTAAAAGTTTTACATTAACGATGAGGTATATAAAGGTAAAATGCGTTAAGTCAACTTCAAGTAATACCAAAGCTTTACATTAACTATGAGGTATATAAAGATACAATTTTGTATTTTTTTGTTAAAATGTGTACAGGTTTTAGATTAACTATAAGTTATATAAAGTGAAAACACTAGGCTTTGCCTAGTTCTCCAAAGCTTGTTTTACATTGACCATGTGGTATATAAAGATCTTATTGTGGGTTTAAAATGGCTTAAATTCAACAGTTCTACATTAACTATGAGGTATATAAAG	GAAGAGGATATAAGGGGATACTTAGCAACAAAAGA
GTTTTATATTAACTATGAGGTATATAAAG	GAGCGGAATTCGTTTAATTGGATTATAAATAATATA
GTTTTATATTAACTATGAGGTATATAAAG	GACACGTTATTAACTGTATTAAATCTTTAATATTTG
GTTTTATATTAACTATGAGGTATATAAAG	CTAGCTAAGTCTTGTATCAGCGTAGCAGGATACTT
GTTTTATATTAACTATGAGGTATATAAAG	AAGAAGAAAGATGGAATTTATGCAATAGTAATGGAA
GTTTTGCATTAACTATGAGGTATATAAAG	TAGCTCCTTGCAGTTTGTTTATACTCCTTTGCCAT
GTTTTACATTAACTATGAGGCATATAAAG	GCAAAAGCATATTCAAATTCCTTGTAAGCGTCTAGG
GTTTTACATTAACTATGTGGTACATAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039629666.1\|2129522_2130506_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_CP014176.1\|WP_039629670.1\|2135721_2136537_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP014176.1\|WP_039629675.1\|2137565_2138888_-\|phosphoserine-phosphatase	unknown	unknown	gnl\|CDD\|273653
NZ_CP014176.1\|WP_039629672.1\|2136619_2137171_+\|phosphodiesterase	unknown	unknown	gnl\|CDD\|181869
NZ_CP014176.1\|WP_160289165.1\|2139740_2139908_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039629679.1\|2140492_2141995_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|234838
NZ_CP014176.1\|WP_039629656.1\|2122559_2123288_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP014176.1\|WP_052267823.1\|2121017_2121935_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NZ_CP014176.1\|WP_039629682.1\|2142997_2144107_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|180542
NZ_CP014176.1\|WP_052267824.1\|2123300_2125109_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09665_cas8b2_CAS-I-B	gnl\|CDD\|187796
NZ_CP014176.1\|WP_039629662.1\|2126819_2128991_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|273707
NZ_CP014176.1\|WP_039629664.1\|2129002_2129530_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP014176.1\|WP_039629680.1\|2142010_2142973_+\|cobalamin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|234919
NZ_CP014176.1\|WP_039629726.1\|2144743_2145616_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_CP014176.1\|WP_039629668.1\|2130509_2130773_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP014176.1\|WP_039629686.1\|2145624_2147094_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|273643
NZ_CP014176.1\|WP_039629659.1\|2126015_2126663_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789
NZ_CP014176.1\|WP_039629684.1\|2144130_2144775_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235504
NZ_CP014176.1\|WP_039629654.1\|2122163_2122424_+\|transposase	unknown	unknown	gnl\|CDD\|366690
NZ_CP014176.1\|WP_039629658.1\|2125101_2126010_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039629666.1\|2129522_2130506_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	1.9846e-154
NZ_CP014176.1\|WP_039629670.1\|2135721_2136537_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.55158e-36
NZ_CP014176.1\|WP_039629675.1\|2137565_2138888_-\|phosphoserine-phosphatase	gnl\|CDD\|273653	TIGR01488, Phosphoserine_phosphatase, Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like. This model represents a subfamily of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. Subfamily IA, B, C and D are distinguished from the rest of the superfamily by the presence of a variable domain between the first and second conserved catalytic motifs. In subfamilies IA and IB, this domain consists of an alpha-helical bundle. It was necessary to model these two subfamilies separately, breaking them at a an apparent phylogenetic bifurcation, so that the resulting model(s) are not so broadly defined that members of subfamily III (which lack the variable domain) are included. Subfamily IA includes the enzyme phosphoserine phosphatase (TIGR00338) as well as three hypothetical equivalogs. Many members of these hypothetical equivalogs have been annotated as PSPase-like or PSPase-family proteins. In particular, the hypothetical equivalog which appears to be most closely related to PSPase contains only Archaea (while TIGR00338 contains only eukaryotes and bacteria) of which some are annotated as PSPases. Although this is a reasonable conjecture, none of these sequences has sufficient evidence for this assignment. If such should be found, this model should be retired while the PSPase model should be broadened to include these sequences. [Unknown function, Enzymes of unknown specificity].	2.09391e-05
NZ_CP014176.1\|WP_039629672.1\|2136619_2137171_+\|phosphodiesterase	gnl\|CDD\|181869	PRK09453, PRK09453, phosphodiesterase; Provisional.	2.11361e-100
NZ_CP014176.1\|WP_039629679.1\|2140492_2141995_+\|cobyric-acid-synthase	gnl\|CDD\|234838	PRK00784, PRK00784, cobyric acid synthase.	0
NZ_CP014176.1\|WP_039629656.1\|2122559_2123288_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.10233e-21
NZ_CP014176.1\|WP_052267823.1\|2121017_2121935_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	7.80837e-43
NZ_CP014176.1\|WP_039629682.1\|2142997_2144107_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|180542	PRK06358, PRK06358, threonine-phosphate decarboxylase; Provisional.	4.50341e-92
NZ_CP014176.1\|WP_052267824.1\|2123300_2125109_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187796	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	2.51489e-14
NZ_CP014176.1\|WP_039629662.1\|2126819_2128991_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	3.18507e-69
NZ_CP014176.1\|WP_039629664.1\|2129002_2129530_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.08162e-59
NZ_CP014176.1\|WP_039629680.1\|2142010_2142973_+\|cobalamin-biosynthesis-protein	gnl\|CDD\|234919	PRK01209, cobD, cobalamin biosynthesis protein.	1.7567e-145
NZ_CP014176.1\|WP_039629726.1\|2144743_2145616_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	7.04165e-139
NZ_CP014176.1\|WP_039629668.1\|2130509_2130773_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.8254e-26
NZ_CP014176.1\|WP_039629686.1\|2145624_2147094_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|273643	TIGR01469, Uroporphyrinogen-III_C-methyltransferase, uroporphyrin-III C-methyltransferase. This model represents enzymes, or enzyme domains, with uroporphyrin-III C-methyltransferase activity. This enzyme catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). Cobalamin contains cobalt while siroheme contains iron. Siroheme is a cofactor for nitrite and sulfite reductases and therefore plays a role in cysteine biosynthesis; many members of this family are CysG, siroheme synthase, with an additional N-terminal domain and with additional oxidation and iron insertion activities. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	1.96485e-118
NZ_CP014176.1\|WP_039629659.1\|2126015_2126663_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	1.10126e-41
NZ_CP014176.1\|WP_039629684.1\|2144130_2144775_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235504	PRK05562, PRK05562, NAD(P)-dependent oxidoreductase.	1.02509e-61
NZ_CP014176.1\|WP_039629654.1\|2122163_2122424_+\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	0.00588164
NZ_CP014176.1\|WP_039629658.1\|2125101_2126010_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	1.87107e-57

>NZ_CP014176.1|WP_039629668.1|2130509_2130773_+|CRISPR-associated-endonuclease-Cas2
MFVIITYDVGEKRVNRVRKILKKYLIWTQNSVFEGAITEGKLNKCMAEINKISNRNEDSVYIYKVSNPHNIKKDVYGINRNLDDLFI
>NZ_CP014176.1|WP_039629666.1|2129522_2130506_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MSSDYYIFSNGRIMRKENTIYFEGAECGRKAIPIEEVERIHLFGEVDLNTKLLNYISQYGIMLNFYNYYGFYSGTYYSRKKNVSGLLNVKQAKHYLDYSRRLYLAQSFIDSAVHHILKNLRRHKEKVAENIEYIENERKNICRVNTIEKLMGIEGRIRKSYYQCFNSILKYEFTFKKREKRPPTDPVNALISFGNSLMYTTTLGQIYETQLDSTISYLHEPSTKRFSLTLDISEIFKPLIIDNLIFYCINNKILQKEDFDNNEGICFLSEAGKKKFIREYDKKLNTTVKHRSLNRSVSYKTFIKLECYKLVKYFIEDEPYKPLKAWW
>NZ_CP014176.1|WP_039629664.1|2129002_2129530_+|CRISPR-associated-protein-Cas4
MEFSLEEYKTNGVKLNYYYICKRKLWLFDKGISFENSNDRVLQGKILHENSYSREKNKEILVDGMIKLDILDKDYIKEVKISSKMENSDKMQLLYYLFYLKELGINKKGKLNYIKEKKTEEIELTNEHEKEIKNALIDIKEILSKDKPPIMQKLKYCKKCSYYEFCFIKEGDINE
>NZ_CP014176.1|WP_039629662.1|2126819_2128991_+|CRISPR-associated-helicase/endonuclease-Cas3
MFYAKTKPEKESIRKHTDNVLKNYELLKEVYSHKIDNLCDMNCERLWYLLRIACEYHDYGKANLAFQNKLKKILGETAEKEADYEEIPHNYLSPAFLPMDKLSEDEQILLSQVIAYHHEREKEPINGEIEYIVKNDLANNLKAITSEMGIEVNKLRSKYSSDIAKKRRITNKSSSYKDYIIMKGLLHRMDHSASAHIVIEEKVDKSVAQCTKEFFDMESESKKKYELREPQLFAMENRDENLLLIASTGIGKTETALFWINDDKAFFTLPLRVSINALYSRVQKDIGFNSIGLIHSTSKEYLVEQGFEDYAEINEQSKLLSKKLNFSTIDQIFKFPFKFKGYEKIYATLAYSKVVIDEIQAYSPEMTAVILKGLEMIHEIGGKFMVMTATFPRIYRDYLNKKGINLKEAEFILDKKRHKIKLNNKSICDDVDNIIEKAKEKKVLVIANTVKRSLEIYDLIKKAGYDDVKLLHSMFIQEDRARLEGEIKEFADKGTKGIWVTTQIVEASLDIDFDYLFTEMSTLDSLFQRFGRCYRKREYKGEVPNVYIYTKDITGVGTIYDEDILNKSINYINVYDETMIEERVKAQLVDKLYSKEELDGTEFYNKFKNAIGCLENIIDYDVTNNEAQKLLRDIETIRAIPEEIYIENIELFEKYRYAIEKKEREKLLMSINKLIVNIPEYKLKISKANIEDIDIEHLKGLKRLKTKYSSTIGVTMDNLDNIF
>NZ_CP014176.1|WP_039629659.1|2126015_2126663_+|type-I-B-CRISPR-associated-protein-Cas5
MKVLKLEIYQETACYKKPFAFKVTETYPLPPYSTVSGMIHKIIGAEEYVPMEISIQGDYESIFTSYNTMYFYKSKEVTSMPINTHMLLGVNLIIHIKAENEVLDNIYESIKNSSEFFSLGRREDLANLIYFDYEELHELNLDDEDEAYEFKHSIYIPKNKCRNLSGVNYKLNRKYKVVRDIRQWEKVPAMYVGKGETINRGMILIDGDGDVAFLA
>NZ_CP014176.1|WP_039629658.1|2125101_2126010_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSKGLTISVVFLAQSLNYGEGIANIAELKKLTRMDGNMYSFASRQAIRYDMVRLGHDLFNWNLQVVDKAKGTIQFRDDISIKESVEMDLFGYMKTAKKDIGNKGGSLTRSAVARLSNAISLEPYRSDMDFLNNKGFADRIGEHPNLANSEQHLSYYTYTLTIDLEKAGIDGDIKLDNEERSKRVNQLLDIVKVLNRNIRGRQENLSPLFVIGGVYDMANPFFLGRIKVNTVNGKYEIDSKMVFKTSEMTLGDIAIKDNTYVGMVDGIFNNEEEFAEEFGNRVVSIENFFKVLKESVNSYYGM
>NZ_CP014176.1|WP_052267824.1|2123300_2125109_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MKIKIYLGEWFYNLGLVGFHRIIKHNNIDELEYDYKLGEDYIEFDSNLLNNFHEYYFKYFLDRYDSAKDQWLKIQRYLSLIKKKPEKIKDYLKFIKEIVKKNNDKIKKIDESIFYKADEIYKSLAKIKKEDDVEELEIELLKYKEILFDRKINERITLNKYKSILSNSFFGQVSYLNVVNTAKTIEEQKRIMFNDYISPILDRKEIEKSVKNIYDHEEFSEFIEEFGKKEKSNKNIEKLCKDINKNFIKKKRGLNELENYIDENYYTCSMCCNEKSLGHNFSEGDFLPLGVSNDNTRNMFWNMNITYPICDICRLILICTPAGTVDIFKGYMDGNFGYEDKIYYGFVNMDIDVDELIKINENFKIRQDKESPFKELLLDMVDTEKKIGVWQLQNILYVEFNSDYTSKNCKMNYCHIPKYLAKFLQDKAMLIKGIKDEKLKAEILDNIIKNIDLKFVTDKKLRQILRNEYSSSFNCLRLTEINYYIRKYKGGITMKDKEDKRLKDLYDQGTNIAKNFIDNKEENKISGIIYRLLNATKSNNKKDFMDTILRLHVSRELEVSHLFLQVLNENELSFDEVSHAFISGLTWNGKPKNKIKEENKNE
>NZ_CP014176.1|WP_039629656.1|2122559_2123288_+|CRISPR-associated-endoribonuclease-Cas6
MRIKCEYKTDKFPLMYQMMIVGLIKKSLKQSNKSYYEQLYTYNDKKNKQIKNFTFSVFMNGYKIVDDIAEIENSITVIISTPDLELGINLYNGLLNTKEFKYKSFELKKQRISLIKEKAINEGEAMFKTLSPIAVKNRDGRFIDINNEDYEQEINYIVDLTLRTHRGYGLKEPIKFIPVSMKKVVVKEKISSFKEITNKDIMYVNSYGGVFKLVGAREDLEEIYKSGIGYRRSQGFGNIDLI
>NZ_CP014176.1|WP_039629654.1|2122163_2122424_+|transposase
MKRKTYPLEFKKKVIDEWYTKGKSLKVLSDEYGIAKATINYWIKSIPYDKDNNFTLNNHKILLKRLKEVEKENFKLKTIISMLTMQ
>NZ_CP014176.1|WP_052267823.1|2121017_2121935_+|WYL-domain-containing-protein
MLMLLKINGKMKIRDLSDKLEVKERMIRTYKDDLELAGIYIKSERGENGGYSLEGNDILVNLDVRDDEIVALNMALAQLNQSGFIANDELEELYYKLCITKSKKASEFEESVFFYKDIKSNDLSDEKEKIKEIINAYIEKKKIKINYYSLSSNETKERIVHPYSVVTYKGANYMVAFCEKRNKFLDFKVSRIDSMEILNEKYNNDKGFSLKDYMEGSIGIYKGESVSVKLKITHPMSRIVSEKKWVDNQKISWIDEKAIHFEAEVKGKTELISWILSMGQNVEVLEPIELKEEIKSIAKNIVNNI
>NZ_CP014176.1|WP_039629670.1|2135721_2136537_+|alpha/beta-hydrolase
MPKLNIEDYNIHYESYGSGEPIIFLSGILMSTISWHPFRKSFNDYNLILIDLIDQGQSSSANFQYDQNLQVEILYKFIEELNIDKCHIMGISYGGEVALQFALKYPHMLKSIILSNTTCHNSNIMKDIKELWDFAASTYDGRILFKATMPYIYSHKFYEENIQWLKKKEEAFSIGLTKQWYDSFRRIIKSASNLNLIEEIKNISLPTMIIGSEYDILTPICYQKLIHKKIKGSRMVVIEKAGHAVIYEKPIEFIAAIKGFLESYNQDIKIL
>NZ_CP014176.1|WP_039629672.1|2136619_2137171_+|phosphodiesterase
MKLFFMSDIHGSLKYAKLGVEAFIKEEADYMVILGDVLYHGPRNPLPEEYNPKEVANLLNEYAEKIIGVRGNCDAEVDQMLLTYPCMMDYNVILTRNRRIFVTHGHIYNENNLPNISKGDIIIYGHTHIPVAESENGIFIFNPGSIAYPKENNPHSYGVIDGNKFYIKNLEGEVIKEIDILAN
>NZ_CP014176.1|WP_039629675.1|2137565_2138888_-|phosphoserine-phosphatase
MNNFKRKTLGLSLACIMSFSLVACGNSAKTEETKNDTKVEQTDNKNEVKLEKGNWAPENYAALTDLIEKYGKNSKDYDEKKKPYAVFDWDNTSIINDVEEALLAYQLENLEFKMTPEEFSNTIRINIPKDNFVEACNNDEGKPVNIELVGADIDSDYKFLYENYKGFKGTKSLDEIKATPEYKDFIAKTRYLYNSIGESFSSDVSYPWVTYLFAGMTEKEVSELTEKSNDYWLNHELGEETWTSPKELAGKAGVVSVKFHSGLRTIKEQQNLYKTLMDNGIDVYICSASFIDVVRTFATNPKFGYELPKENVFAMELERDDKGVIKAEFRKGYDQTQSKGKTKTIEKFLVENHGGQGPLIVGGDSAGDVAMLSDFKDTKFGLIINRCKGDELGKLSKEAADTIGKSDARYYLQGRDENTGEFRASQKSVFLGSKEEKLLK
>NZ_CP014176.1|WP_160289165.1|2139740_2139908_+|hypothetical-protein
MQEIVSVVSHATIFRNDSERNPQIFVDVFNLTITKLMRLASKVSYVHSVGIKIQK
>NZ_CP014176.1|WP_039629679.1|2140492_2141995_+|cobyric-acid-synthase
MAKIMVQGTASSVGKSILVTALCRIFKQDGYKVCPYKSQNMSLNSYITLDGKEMGRAQVLQAYACGLEPEAYMNPILLKPTSDRKCQIIVNGEVYGNSTAMEYHNMKLEFRDMLKAQFEELENQFDIIVMEGAGSPAEINLRDRDIVNMGMAELVDAPVVLVGDIDKGGVFASLVGTLMLLTEEERDRVKGTIINKFRGDVDILKPGIDMLEDISKKQCIGVVPHCTLALEDEDGAVELNKKITNKIDIAVIKLPRISNFTDVDALKNEEDVSVRFITSVEEFKNPDLLIIPGSKNTIEDLNALKTSGLFDKIKEYSKNGEIIGICGGYQMLGKKITDPYGVETELSEIEGLGLLDIETVFEQKKVTTRVEADLIDNKIFTTDRDKLSVYGYEIHMGICKYGKNANPLFNIKTQNTKEVNYNDGAINEYGNIMGSYIHGIFDKTDFREVIVNKLRSKKGIELKKSKPYESLREEELDKLADLVRKTLDMDEIYKMMGIKR
>NZ_CP014176.1|WP_039629680.1|2142010_2142973_+|cobalamin-biosynthesis-protein
MFNFNLKANIIYVLIAMVIDFILGDPAWLPHPIIYIGKLIAKLENYFRKGEKSDEGLRICGGLIVLIVCFITYTIPYALLKLSLINEYLFHGLNVFIIWTTLAAKSLHGAAIEVYKSLEKRDIEDARVKLSYIVGRDTANLEEDEIIRADIETVAENASDGIIAPIFYAILGGAPLAMMYKGVNTMDSMLGYLNEKFKYIGFFPAKVDDLFNLIPARLTGVLMCLTSFVVGGNIEDSFRIMIRDRKNHKSPNCAYPEAAAAGAMKIQLGGTNVYFGEIVYKPTLGDRIKGLEARDIKQSIKLMYSSEILLVLVSLILVVI
>NZ_CP014176.1|WP_039629682.1|2142997_2144107_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MKHGGDIYSEGLLKGRKLLDFSSNINPLGVPKGFIENINEGIEMLQVYPDIKYRTLKDNIINYLNKCNYYFGGEADELNLTHESILLGNGASEIIDLAIRYLKSITIVVPSFVEYEDNSHRYNLEVSYSYLKDDFTYDYEDILNKLNYSEGLIIGNPNNPNGSIIDKEKFISILDFCEENNKIVLIDEAFIEFTGSSNYSLLNLVEKYKCLFIIKAITKFYGLPGVRLGFGITKNKALIDYIVSMQNPWNINCFAELSAKYALSDEAYIRDSLKWIETERKYMIEELNKISIIEKCHNSYGNYVLCELKGINCDKLYSYLEEKCIIIRKCNNFRGLDDKFVRFAIKDRGSNEKLIEHLKNIDPLKIKDI
>NZ_CP014176.1|WP_039629684.1|2144130_2144775_+|NAD(P)-dependent-oxidoreductase
MKNLEQCFLSIKSDKFKVLIVGGGKAGYIKCKSFLTKGAEVKVIALDICKEVLSLQHFEKLSIEKTTYNKEMLVKYHLVVIATDDEFLNRNIKMDCDELCKLYINSSNVEESMCITPTVGESKSTVFAIHTKKFSPKTSLFIRDNLETHLKKYDSYIDFSVNLRNSLKNHSRKNEILNFISTEDFLYIFNKGYGEKIINLFYGGNRIENSNEKE
>NZ_CP014176.1|WP_039629726.1|2144743_2145616_+|hydroxymethylbilane-synthase
MELRIATRKSKLAQVQTEFVMEIIDKTHNIKCEKVLTDTLGDKRLDVTLDKIGGKGLFIKELEQLILDGHAEAGVHSMKDMPYELPEGFIVAAMPIREDVRDAFVSINGVKFKDLKKGAKVGTSSNRRASQLKILRPDIEIVPIRGNVQTRIDKIKKENLDGIILAAAGLKRLGMDEIITDYFEPHEMIPAIGQGALGIEIHESCKDKEVFTALDDYETRVCVEAERSFMAALKGDCHAAIGAYAELKDNTINMIGIYEVNGNLVRKEVTGPVNENIKLGEELASLILNS
>NZ_CP014176.1|WP_039629686.1|2145624_2147094_+|uroporphyrinogen-III-C-methyltransferase
MSKVYLIGAGPGHEELITMRAINVLKQCTAIMYDRLCGESFLQYINPNAEIYYCGKEPGCHYKNQNEINDMIVELAKKGHIVGRVKGGDPYIFGRGGEEALRLLEENIEFEVVPGITSPISVLNYAGIPVTHRGIARGFHIFTGKSNDNMDLNFEVISKLNGTLIFLMSFEKLEIITKSLMENGMSSDTPAAVVMRGTTSKQKKAIGTLSNIVEKALEKNLSNPSIIVVGEVVQFHDKLNWFERRPLFGKNICITRTKEQSKEIKTKLLNLGAEVTEINSIKIKPTPEKLEPYLDKLSLYDYIVITSANAARVFFEYLIEREIDVRTIKAQIITIGPASDSAIRSYGVIPKLCAEEYVAENLFSHMESFIKENDKILLPRSKNARVFLTEAFESKGCIVDECHIYETETGEAVGLNRFVDCDAVVFTSPSTLTNMIKLVGIEEVKKKTVVSIGPITSVELNKHNIEHIVCDESSNEGMINKLIEIYSES

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Crispr_ID: NZ_CP014176_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_3

2566990-2568200

TypeV

NA:III-B

Consensus_repeat	Method
ATTTAAATACATCCTATGTTAAGGTTCAAC	CRISPRCasFinder
ATGTTAAGGTTCAACNNN	CRT

18 spacers

The CRISPR arrays of NZ_CP014176_3

>merge|NZ_CP014176|3|2566990-2568200|CRISPRCasFinder,CRT
TATTAATTACATCATATGTTAAGGTTTAATAATTGTAATTTAGACGAAGTGTCTATGGCAATGTTATTTAAATACATCTTATGTTACGGTTCAATTGTATTCAGAGTAGAGACTTTATGTTGCTATCCTCATTTAAATACATCCCATGTTAAGGTTCAACATGATTTAAAAGACTTTGTTACTACAGTAGTTATATTTAAATACATCTCATGTTAAGGTTCAACTTGCTCAACTTTTAAATACAAAGGTGGTAAGAGTAATTTAAATACATCTCATGTTAAGGTTCAACAGATTATAATACACTTCTAACAATAAAACTTATCCTATTTAAATACATCATATGTTAAGGTTCAATATGGATTCATAAAGGAATTGGATGTTTTACAAATGGATTTAAATACATCTTATGTTATGGTTCAACATTATTGGTTATGATGAAATTGATTTAGAAACTACATTTAAATACACCCCATGTTATGGTTCAACAAGAAAATCCTATGGTATACGTGTCAATGCCTAAATAATTTAAATACATCATATGTTAAGGTTCAACGAAAAGAAAGAAACTTACATAGTTGCTTACATTTAAATTTAAATACATCTCATGTTAAGGTTCAACCCTGGAAATGCTAATGATTTTAGGAAACAGGCTGAATTTAAATACATCTCATGCTAAGGTTCAACGAACATTTAAAAGATAGAATAGACTTAGCACTAACATTTAAATACATCCTATGTTAAGGTTCAACTGCACTTAAAAAACTTCAAGATCAAATTGGAAATATATTTAAATACATCCTATGTTAAGGTTCAACATTATAGAATTATTGCACAGTTATTCAAAAGACTAATTTAAATACATCCCATGTTAAGGTTCAACTTTTTCAATTCCTAATGCCTTCGAATTACCTCTCATATTTAAATACATCTCATGTTAAGGTTCAACTTTATTGCAAAAAATATAAATGTTCAGTTCATCAATTATTTAAATACATCCCATGTTAAAGTTCAACAAAATGGTAGAAGGTTTAAAAGAAAAAATGCAACAATTTAAATACATCTTATGTTAAGGTTCAACATTTATTTTAAATATAAAAACAATGTTTATAGTCAATTTAAATACATCTTATGTTAAGGTTCAACCTGCATCTGCTATTAGCTTTACTAGTTCTTTACACATTTAAATACATCTTATGTTAAGGTTCAACTAC

>NZ_CP014176|3|3|2566990-2568197|CRISPRCasFinder
TATTAATTACATCATATGTTAAGGTTTAAT	AATTGTAATTTAGACGAAGTGTCTATGGCAATGTT
ATTTAAATACATCTTATGTTACGGTTCAAT	TGTATTCAGAGTAGAGACTTTATGTTGCTATCCTC
ATTTAAATACATCCCATGTTAAGGTTCAAC	ATGATTTAAAAGACTTTGTTACTACAGTAGTTAT
ATTTAAATACATCTCATGTTAAGGTTCAAC	TTGCTCAACTTTTAAATACAAAGGTGGTAAGAGTA
ATTTAAATACATCTCATGTTAAGGTTCAAC	AGATTATAATACACTTCTAACAATAAAACTTATCCT
ATTTAAATACATCATATGTTAAGGTTCAAT	ATGGATTCATAAAGGAATTGGATGTTTTACAAATGG
ATTTAAATACATCTTATGTTATGGTTCAAC	ATTATTGGTTATGATGAAATTGATTTAGAAACTAC
ATTTAAATACACCCCATGTTATGGTTCAAC	AAGAAAATCCTATGGTATACGTGTCAATGCCTAAATA
ATTTAAATACATCATATGTTAAGGTTCAAC	GAAAAGAAAGAAACTTACATAGTTGCTTACATTTAA
ATTTAAATACATCTCATGTTAAGGTTCAAC	CCTGGAAATGCTAATGATTTTAGGAAACAGGCTGA
ATTTAAATACATCTCATGCTAAGGTTCAAC	GAACATTTAAAAGATAGAATAGACTTAGCACTAAC
ATTTAAATACATCCTATGTTAAGGTTCAAC	TGCACTTAAAAAACTTCAAGATCAAATTGGAAATAT
ATTTAAATACATCCTATGTTAAGGTTCAAC	ATTATAGAATTATTGCACAGTTATTCAAAAGACTA
ATTTAAATACATCCCATGTTAAGGTTCAAC	TTTTTCAATTCCTAATGCCTTCGAATTACCTCTCAT
ATTTAAATACATCTCATGTTAAGGTTCAAC	TTTATTGCAAAAAATATAAATGTTCAGTTCATCAATT
ATTTAAATACATCCCATGTTAAAGTTCAAC	AAAATGGTAGAAGGTTTAAAAGAAAAAATGCAACA
ATTTAAATACATCTTATGTTAAGGTTCAAC	ATTTATTTTAAATATAAAAACAATGTTTATAGTCA
ATTTAAATACATCTTATGTTAAGGTTCAAC	CTGCATCTGCTATTAGCTTTACTAGTTCTTTACAC
ATTTAAATACATCTTATGTTAAGGTTCAAC

>NZ_CP014176|3|3|2567005-2568200|CRT
ATGTTAAGGTTTAATAAT	TGTAATTTAGACGAAGTGTCTATGGCAATGTTATTTAAATACATCTT
ATGTTACGGTTCAATTGT	ATTCAGAGTAGAGACTTTATGTTGCTATCCTCATTTAAATACATCCC
ATGTTAAGGTTCAACATG	ATTTAAAAGACTTTGTTACTACAGTAGTTATATTTAAATACATCTC
ATGTTAAGGTTCAACTTG	CTCAACTTTTAAATACAAAGGTGGTAAGAGTAATTTAAATACATCTC
ATGTTAAGGTTCAACAGA	TTATAATACACTTCTAACAATAAAACTTATCCTATTTAAATACATCAT
ATGTTAAGGTTCAATATG	GATTCATAAAGGAATTGGATGTTTTACAAATGGATTTAAATACATCTT
ATGTTATGGTTCAACATT	ATTGGTTATGATGAAATTGATTTAGAAACTACATTTAAATACACCCC
ATGTTATGGTTCAACAAG	AAAATCCTATGGTATACGTGTCAATGCCTAAATAATTTAAATACATCAT
ATGTTAAGGTTCAACGAA	AAGAAAGAAACTTACATAGTTGCTTACATTTAAATTTAAATACATCTC
ATGTTAAGGTTCAACCCT	GGAAATGCTAATGATTTTAGGAAACAGGCTGAATTTAAATACATCTC
ATGCTAAGGTTCAACGAA	CATTTAAAAGATAGAATAGACTTAGCACTAACATTTAAATACATCCT
ATGTTAAGGTTCAACTGC	ACTTAAAAAACTTCAAGATCAAATTGGAAATATATTTAAATACATCCT
ATGTTAAGGTTCAACATT	ATAGAATTATTGCACAGTTATTCAAAAGACTAATTTAAATACATCCC
ATGTTAAGGTTCAACTTT	TTCAATTCCTAATGCCTTCGAATTACCTCTCATATTTAAATACATCTC
ATGTTAAGGTTCAACTTT	ATTGCAAAAAATATAAATGTTCAGTTCATCAATTATTTAAATACATCCC
ATGTTAAAGTTCAACAAA	ATGGTAGAAGGTTTAAAAGAAAAAATGCAACAATTTAAATACATCTT
ATGTTAAGGTTCAACATT	TATTTTAAATATAAAAACAATGTTTATAGTCAATTTAAATACATCTT
ATGTTAAGGTTCAACCTG	CATCTGCTATTAGCTTTACTAGTTCTTTACACATTTAAATACATCTT
ATGTTAAGGTTCAACTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039630252.1\|2560841_2561657_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350160
NZ_CP014176.1\|WP_039630250.1\|2561668_2562844_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_CP014176.1\|WP_039630254.1\|2559952_2560771_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|350160
NZ_CP014176.1\|WP_039630238.1\|2569069_2569813_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP014176.1\|WP_039630233.1\|2570760_2571000_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039630240.1\|2565502_2565991_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039630231.1\|2573927_2574380_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379352
NZ_CP014176.1\|WP_039630241.1\|2564713_2565232_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP014176.1\|WP_039630224.1\|2578193_2579888_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP014176.1\|WP_039630236.1\|2569826_2570048_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378518
NZ_CP014176.1\|WP_039630226.1\|2576499_2577687_-\|SpoIVB-peptidase	unknown	unknown	gnl\|CDD\|274325
NZ_CP014176.1\|WP_039630258.1\|2557069_2558260_-\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_CP014176.1\|WP_039630245.1\|2563773_2563998_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039630248.1\|2562877_2563756_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|274043
NZ_CP014176.1\|WP_052267918.1\|2570996_2572070_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_080618951.1\|2575503_2576313_-\|sporulation-transcription-factor-Spo0A	unknown	unknown	gnl\|CDD\|131922
NZ_CP014176.1\|WP_039630235.1\|2570200_2570395_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039630256.1\|2558583_2559888_-\|pyrimidine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180387
NZ_CP014176.1\|WP_039630243.1\|2564016_2564640_-\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|131878
NZ_CP014176.1\|WP_039630239.1\|2568567_2568885_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039630252.1\|2560841_2561657_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|350160	cd09009, PNP-EcPNPII_like, purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA). Human PNP catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. Patients with PNP deficiency typically present with severe immunodeficiency, neurological dysfunction, and autoimmunity. Escherichia coli PNPII, product of the xapA/pndA gene, catalyzes the phosphorolysis of xanthosine, inosine and guanosine with equal efficiency and has been referred to as xanthosine phosphorylase and inosine-guanosine phosphorylase. E. coli PNPII is also capable of converting nicotinamide to nicotinamide riboside, and may be involved in the NAD+ salvage pathway. It is one of two purine nucleoside phosphorylases found in E. coli, which also contains PNPI, which displays a different substrate specificity and belongs to a different subgroup of the nucleoside phosphorylase-I (NP-I) family than PNPII. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.88229e-172
NZ_CP014176.1\|WP_039630250.1\|2561668_2562844_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP014176.1\|WP_039630248.1\|2562877_2563756_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|274043	TIGR02225, Tyrosine_recombinase_XerD, tyrosine recombinase XerD. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	1.81376e-125
NZ_CP014176.1\|WP_039630238.1\|2569069_2569813_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	1.38556e-42
NZ_CP014176.1\|WP_039630231.1\|2573927_2574380_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379352	pfam13730, HTH_36, Helix-turn-helix domain.	2.81585e-09
NZ_CP014176.1\|WP_039630256.1\|2558583_2559888_-\|pyrimidine-nucleoside-phosphorylase	gnl\|CDD\|180387	PRK06078, PRK06078, pyrimidine-nucleoside phosphorylase; Reviewed.	0
NZ_CP014176.1\|WP_039630241.1\|2564713_2565232_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	2.13693e-53
NZ_CP014176.1\|WP_039630224.1\|2578193_2579888_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
NZ_CP014176.1\|WP_039630226.1\|2576499_2577687_-\|SpoIVB-peptidase	gnl\|CDD\|274325	TIGR02860, stage_IV_sporulation_protein_B, stage IV sporulation protein B. SpoIVB, the stage IV sporulation protein B of endospore-forming bacteria such as Bacillus subtilis, is a serine proteinase, expressed in the spore (rather than mother cell) compartment, that participates in a proteolytic activation cascade for Sigma-K. It appears to be universal among endospore-forming bacteria and occurs nowhere else. [Cellular processes, Sporulation and germination].	5.88848e-159
NZ_CP014176.1\|WP_039630258.1\|2557069_2558260_-\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	2.42292e-112
NZ_CP014176.1\|WP_039630236.1\|2569826_2570048_-\|hypothetical-protein	gnl\|CDD\|378518	pfam10960, Holin_BhlA, BhlA holin family. The Phage_holin_BhlA family is a family of holin-like proteins from both bacteriophages and bacterial chromosomes. In bacteriophage, holins are small membrane proteins that accumulate and oligomerize to form non-specific lesions in the cytoplasmic membrane allowing the release of the second protein, endolysins, to access the peptidoglycan. Most holins share common structural features: two or three transmembrane domains separated by a beta-turn, a short hydrophilic N-terminus, a highly charged C-terminus and a dual translational start motif. The BhlA holin of Bacillus is found to be toxic to the host cell where the site of action of is on the cell membrane and causes bacterial death by cell membrane disruption.	3.07922e-16
NZ_CP014176.1\|WP_039630254.1\|2559952_2560771_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|350160	cd09009, PNP-EcPNPII_like, purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA). Human PNP catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. Patients with PNP deficiency typically present with severe immunodeficiency, neurological dysfunction, and autoimmunity. Escherichia coli PNPII, product of the xapA/pndA gene, catalyzes the phosphorolysis of xanthosine, inosine and guanosine with equal efficiency and has been referred to as xanthosine phosphorylase and inosine-guanosine phosphorylase. E. coli PNPII is also capable of converting nicotinamide to nicotinamide riboside, and may be involved in the NAD+ salvage pathway. It is one of two purine nucleoside phosphorylases found in E. coli, which also contains PNPI, which displays a different substrate specificity and belongs to a different subgroup of the nucleoside phosphorylase-I (NP-I) family than PNPII. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	4.41522e-164
NZ_CP014176.1\|WP_039630243.1\|2564016_2564640_-\|stage-II-sporulation-protein-M	gnl\|CDD\|131878	TIGR02831, Stage_II_sporulation_protein_M, stage II sporulation protein M. A comparative genome analysis of all sequenced genomes of shows a number of proteins conserved strictly among the endospore-forming subset of the Firmicutes. This predicted integral membrane protein is designated stage II sporulation protein M. [Cellular processes, Sporulation and germination].	2.02543e-37
NZ_CP014176.1\|WP_080618951.1\|2575503_2576313_-\|sporulation-transcription-factor-Spo0A	gnl\|CDD\|131922	TIGR02875, stage_0_sporulation_protein_A, sporulation transcription factor Spo0A. Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination].	1.40964e-149

>NZ_CP014176.1|WP_039630240.1|2565502_2565991_-|hypothetical-protein
MYTKMVFNERSFKGKMWLSLIAILFLCITLIGCNLKEFKGQYENLNIENNKLELNVIDYFEKISSLTSSYNKKEIADELANLIREEEKIIKKYENLKPSKELQENYDGFLELLNEKNELYKEFEISIREDNKFTMESILKDMIKNTKEMTKISNEISNKLSN
>NZ_CP014176.1|WP_039630241.1|2564713_2565232_-|NUDIX-hydrolase
MKLYEKTINKEYIYKGKILNLKIEDVELPNGKTSKREIIEHPGAVAILAFKDKDTLILVEQFRKPLNMSILEIPAGKLEVGENPELCAVRELEEETGYKSKELKYLGKIATTPGFSDEYIHIFKAMNIYEGNIGGDEDEFINLHEYKIEEIKEMIKNGEIIDGKTIAALSFL
>NZ_CP014176.1|WP_039630243.1|2564016_2564640_-|stage-II-sporulation-protein-M
MSLRTLSEGFNRQLDEDLILYFIAILCLCIGIVLGIYGVKKLTAVEKDSIVNYITVISDSYSIKSTSYKSIFFQGVKNNIFIIFAYWGLGLTAIGIPIILILNIFKGFTIGFTFSFFISKLSNKGALLSFFGVLPQNFIYVPCIIFASVLGIKYSFSKIKNKVYYKNINLKSNTLNYSITLLICGLVTFIGILFETFISPFLIKLML
>NZ_CP014176.1|WP_039630245.1|2563773_2563998_-|hypothetical-protein
MNKELRDFLILYLRTLIIIIFMGIILPNILDYTLHLITKGSTIYENSILVCKSIDKQRELLYNYIHIFKLFINF
>NZ_CP014176.1|WP_039630248.1|2562877_2563756_-|site-specific-tyrosine-recombinase-XerD
MNELLKKYIEHLQFKNLSYNTIDAYKRDLTNFIDFLKSRDEELNTIATDVIILYAQKLQKEGKANTSVIRNIISIRNFYKYLLINKIVDEDPTLAYELPKNKKEIPKILTVEEVDKFLLQPDLSTAKGIRDKAMLEVMYATGIKVSELLGLTVYDINLKLLYIKIRSKDGDERIIPLGRTACKYLSEYLEVRDQFNKYNFDLLFLNIKGNKMSRQGFWKIIKYYSKEANINKYMNSYTLRHSFAVHLLQNGADIKSVQELLGHNNMSATQIYSFISRKNKIEEIYRKSHPRA
>NZ_CP014176.1|WP_039630250.1|2561668_2562844_-|phosphopentomutase
MTKKVVLIVLDSVGIGELPDAKEYGDEGSNTLGNIAKSINKFSLPNMEKLGLGHIDEIKNIKTCNNVEGVYGRCMELSKGKDTITGHWELSGVVLEKPLKTYPKGFPKEIIEEFESRIGKKVLGNKVASGTAIIEELGEEHIKTGYPIVYTSADSVFQIAAHEEIIPLQELYNMCKIAREMLVDDKMVGRVIARPFLGNKKGEFKRTSNRHDYALDPFDKTILDYIKENNKSVMAVGKIEDIFNKRGVTHSVHIKDNMDGVDKTIDYMKTEECGLIFTNLVDFDMKYGHRNDVEGYAEALIEFDNRLPEILANLGEDDVLIITADHGCDPTTEGTDHSREYIPVLVYGRQIKKNVNLGTRKSFCDIGKTVLDLLDIENELKGESFKDLLTN
>NZ_CP014176.1|WP_039630252.1|2560841_2561657_-|purine-nucleoside-phosphorylase
MDIKIVMESVDYIKSKLNFQPEIGVILGSGLGDMADTVEERTVIKYSEVPNLPVSTVQGHAGQFVVGKLNGKNVIMMQGRFHYYEGYDISTLALPIYIMKNLGVESLIVTNAAGGVNTSFVPGDLMLINDHINFCGNSPLIGKNDDKIGPRFPDMSEAYSKDYIKLAHEVSSDLNLKLQEGVYMMFSGPTYETPSEVRMARILGADAVGMSTVPEVIAARHCGIKTLGISCITNMAAGILDQPLNHNEVIETSTKVKSQFIKLVKEIVARM
>NZ_CP014176.1|WP_039630254.1|2559952_2560771_-|purine-nucleoside-phosphorylase
MELLEKINGAREYILSKENRKIDLAIVLGSGLGGIVKDIKNTTIIKYKDIPGFPESTVKGHAGEMIIGDLMGKRILAMNGRFHYYEGYSMETVTFPVRVIKSLGIDKIIITNAAGGMNPEFEAGDLMLINDHINMMGDNPLIGKNYKELGPRFPDMSNAYDKELRSIAKNAANTLNIKLQEGIYCPVTGPTYETPYELKMLRKVGGDAVGMSTVPEVIVANHMAMKVLGISCITDMAIAEDLEPLDHSKVMETANKAMNKFISLVKEIIKNM
>NZ_CP014176.1|WP_039630256.1|2558583_2559888_-|pyrimidine-nucleoside-phosphorylase
MRMYDLILKKRNNEELSTEEINFIVENYTKGAIPDYQMSAMLMAIYFQKMNARETADLTMAMVNSGDIIDLSPIRGIKVDKHSTGGVGDTTTLILAPMVAALDIPVAKMSGRGLGHTGGTIDKLETFKNFSVAMSEEQFINNVNNIKIAVGGQTADLAPADKKLYALRDVTATVDNVSLIASSIMSKKIASGADCIVLDVKVGEGAFMKTVENARELGTEMVKIGRSVNRNTIAVLSDMDQPLGLAIGNALEVEEAINTLKGNGPKDLEELCLTLGSHMVVLAEKAKDENEAREMLKEVIKNGKALEKFKEFVKAQGGDESVIDDVSKLPKAKYVIPVLSPKAGVVEKIHAERLGIVAMELGAGRATKESIIDLAVGIVLNKKRGDKVEENEVLAYIHSNDGSNIERAKAGVISNYVISPNYEDNIPLIYDVIK
>NZ_CP014176.1|WP_039630258.1|2557069_2558260_-|D-alanyl-D-alanine-carboxypeptidase
MKKNKKTLLSLLLSFTLLSQFLVIPVKAEDKINKEATTNAVEVDAKSALLIEPSSGKVIFEKNPNEKFAPASVTKIMTMLLAMEAIDSGKLKLDDKIVCSAKVKSMGGSSMILDEGEVRTVEEILKGIAIASGNDAAVAMAEQVGGTEEAFVEMMNKRAQELGMKNTTFRNCTGLSAEGHLTTANDIAIMSMELLKHPTILNYSSIYMETISEGRKSPIELVNHNKLVRFYEGCDGLKTGFTEEAKYCISATSVRNNVRMLAIIMGSPTYKIRNADASKLMTYGFAKFESKDAVRKDEEIERVALNKKGDNFFIAKAKDNLKVTMEKNSEEEIVKKTTIDTTRKHYKEGDIVGHCEVYVGDKLLGKVELYSDREVKQSEFFKNIKNNISDLFDKAI
>NZ_CP014176.1|WP_039630239.1|2568567_2568885_+|hypothetical-protein
MKLKKVLACTLLGITMITSANVATTYAAVADGDGDTPLRDLGRHYGVSVKWNDNSNEIIIADLYHYSTKKICDRVVNGTCMKLKDSFHNLLHDKDIDHKNCDYEK
>NZ_CP014176.1|WP_039630238.1|2569069_2569813_-|N-acetylmuramoyl-L-alanine-amidase
MKIGIDCGHTLSGDDYGAVGIKAESVLTREVGTRVINKLKALDHSVINCTIDTCNSLEKSLAYRVNQANNNNVDLFISIHFNAYNGQVHGTEILTWGAEQLPEATRVLNNLVGLGYANRGIKDGSNLYVIRNTKSKAMLIECCFCDNKEDMNKYDAEKIANAIVEGIAGKSTSNNSNINWYFLDGKTGIVTAKDGLNVREGKSTNSRILETLSYGRKIRLYRKEDNWIHIYHSEHGGYAHAEYIDIL
>NZ_CP014176.1|WP_039630236.1|2569826_2570048_-|hypothetical-protein
MEQEIVKVAISQGLGYTLFVFLLIYVLKTTQERENRLNTTIDKNQSIIQDLAAKLNVIEDVKKDVQDIKNKIN
>NZ_CP014176.1|WP_039630235.1|2570200_2570395_-|hypothetical-protein
MQARKLMKDRELAAYLDINNSNLPFEYYENKYSKQGYTGNLLYRKILEASNRTNKEVNKQLGIM
>NZ_CP014176.1|WP_039630233.1|2570760_2571000_-|hypothetical-protein
MSEVIRIEELIGHKDKTNDYKLGKIDSSYISGRPKIQFDGEDIASLKGYNYISSYTPKAGDRVLLQKVAGTYIILGKII
>NZ_CP014176.1|WP_052267918.1|2570996_2572070_-|hypothetical-protein
MKQLHYATGSREIKYTIELLNKHDIKIGELEAEMTGSIRFDSLAEIKRMANLTVKEKQFKDIDLLNDRIRPVFQLKMPDGGYASWNMGVFLISSPTRKESGANILRDLELYDKSLILKEDKFENRYLVSKGTNYVEAVINIINKAGISKVYIKPTNSIVDVDKEYEIGTNKLEVINSLLKEINYTSLWVDEAGVFRADKYLIPTEREADYTYRDNQLSIIETGSIEELDLFSVANKWIVVASNPEKEPLISKYENVSATSPISIPNRGRTIVDYRTVDDIADQVTLDAYTKCIAYEASQVYGEFRFNTAIMPHHSYADLLFIDHKGMGINSKFTEMNWRINIGSGNMEHTCRKVVYI
>NZ_CP014176.1|WP_039630231.1|2573927_2574380_-|helix-turn-helix-domain-containing-protein
MTNYTIIQNDAITSNLGNGAFRLYCLLQSMCYGEKDSCFPSQNYLAEKLNKSTRTIQRYLQELYNAKLIPKRRRGSISNVYTILGRKILQQVDKAVNKAKNAYRSYTSKRRKEKVSSFNDYEQTQYNFNNLEAVLLGEMEYDPDALLAKD
>NZ_CP014176.1|WP_080618951.1|2575503_2576313_-|sporulation-transcription-factor-Spo0A
MEQTSISVLIADDNKEFCNILNDYLLSQRDINVVAIAKDGIEALKLIQEKKPELVVLDIIMPHLDGLGVLEKLNSMNLDPMPRIIVLSAVGQDKITQRAITLGADYYVVKPFDMDVFTKRIRQMFNNTITSDDTKKPVIVDTPEVKATQNEPMNLEAEITNIIHEIGVPAHIKGYMYLREAITLVVNDIEFLSAVTKELYPTIAKKYNTTASRVERAIRHAIEVAWSRGQVDTINKLFGYTIHNDKGKPTNSEFIAMVADKLRLKNRVG
>NZ_CP014176.1|WP_039630226.1|2576499_2577687_-|SpoIVB-peptidase
MKRWNGLWCFFISIFLSLTISNYSSFNEYIFHNPLKEENRHIEAAYIKDHGLNNIPSSSINDSSNNDILLTQSTYAKTSEIKLCPGGQPVGIKLNTKGALIIALSDIETKDGIVSPATKAGIQIGDSIIKINGVDIKSSEDVSTYVNRCNGDEITITVWRKDETLDIAVKPVLSANDGKYKIGLWVRDSTAGVGTLTFYDNNTGKFGALGHPITDVDTGNIMNISNGEVVSSNIVSVRKGTKGNPGELRGIFVDEEKCLGNIYNNTECGVFGEGNIGLINKSYSDPLPVASRDEIKIGKAQILTTVEGSEPRVYDIEIEKLLPQKEAGSKSMIIRITDKEFLEKTGGIVQGMSGSPIIQNGKIIGAVTHVLINKPDTGYGIYIDWMLNDAGILPK
>NZ_CP014176.1|WP_039630224.1|2578193_2579888_-|DNA-repair-protein-RecN
MLLQLNIKNFALIEELSIDFEEGFNVLSGETGAGKSILIDAINYVLGGKFNKNLIRAGEEKTIVEAIFAIDNEKTKNILDTLEIDYDDVIVLTRESFNTGKSVAKVNNKTLILSKIKLISEVLLDIHGQHENQNLLDNSNHINYVDAFGSDKIEDLLKSYKENYDKLSSIEKKISDLKGNNNQREKNMDFIKFQIDEINNINPKLGEDEELEERFSFLSNAEKIEKSLLSSYNLLKNNLEEGFSVIDGLSYVIRELRTIENHKTEIKNISNALEECFYLIEQNIDEIRTLKDSIYYDEKELEFVNSRMYQLGVCKKKYGETITDVLNYKSDLEKRFDELFNSGEIIEKLEKEKVQLVDIMQKQTLNIHHMRVEISEQLEKNIKKELDYIGLDKSTFKIEIIHTTELLSNGSDKVQFNISTNPGQPLQPLEEIVSGGELSRIMLALKTVFVDKDEIPTVIFDEIDTGISGRIAQRVGEKMYLISKNHQVFCVTHLPQIASMADYNYLITKESLENTTYTNVTKMSKEDKKYEIARMIGGSEVTKLTLDNSEEMIEMANILKRNII

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Crispr_ID: NZ_CP014176_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_4

2872633-2872862

Orphan

III-B

Consensus_repeat	Method
ATTTAAATACATCCTATGTTATGGTTCAATCA	CRISPRCasFinder
ATTTAAATACATCCTATGTTATGGTTCAATCAC	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP014176_4

>merge|NZ_CP014176|4|2872633-2872862|CRISPRCasFinder,PILER-CR
TGTTAGTGACATCTTATGTTAAGGTTCAATATAGACAAATTGAAAGAACAATACAAAGCTGTACCATTTAAATACATCCTATGTTATGGTTCAATCATGGCCTAGCATGGCAGCTAGGAAAAATAAACTTATTTAAATACATCCTATGTTATGGTTCAATCACCTACAGATGTGCAAAATGGTCTAAATAAAATATAATTTAAATACATCCTATGTTATGGTTCAATCAC

>NZ_CP014176|4|4|2872633-2872861|CRISPRCasFinder
TGTTAGTGACATCTTATGTTAAGGTTCAATAT	AGACAAATTGAAAGAACAATACAAAGCTGTACC
ATTTAAATACATCCTATGTTATGGTTCAATCA	TGGCCTAGCATGGCAGCTAGGAAAAATAAACTT
ATTTAAATACATCCTATGTTATGGTTCAATCA	CCTACAGATGTGCAAAATGGTCTAAATAAAATATA
ATTTAAATACATCCTATGTTATGGTTCAATCA

>NZ_CP014176|4|5|2872698-2872862|PILER-CR
ATTTAAATACATCCTATGTTATGGTTCAATCAT	GGCCTAGCATGGCAGCTAGGAAAAATAAACTT
ATTTAAATACATCCTATGTTATGGTTCAATCAC	CTACAGATGTGCAAAATGGTCTAAATAAAATATA
ATTTAAATACATCCTATGTTATGGTTCAATCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039632202.1\|2883970_2884435_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|273638
NZ_CP014176.1\|WP_039632225.1\|2864101_2864827_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176506
NZ_CP014176.1\|WP_052268039.1\|2880128_2881310_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341135
NZ_CP014176.1\|WP_039632205.1\|2881290_2882775_-\|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|223363
NZ_CP014176.1\|WP_039632200.1\|2884569_2885529_-\|tRNA-dihydrouridine-synthase-family-protein	unknown	unknown	gnl\|CDD\|239200
NZ_CP014176.1\|WP_039632209.1\|2875596_2878944_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|226581
NZ_CP014176.1\|WP_039632211.1\|2874728_2875010_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632207.1\|2879054_2879915_-\|DUF4351-domain-containing-protein	unknown	unknown	gnl\|CDD\|316753
NZ_CP014176.1\|WP_039632215.1\|2871596_2872298_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632213.1\|2873235_2873577_-\|alkylphosphonate-utilization-protein	unknown	unknown	gnl\|CDD\|225380
NZ_CP014176.1\|WP_039632219.1\|2868246_2868651_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NZ_CP014176.1\|WP_039632217.1\|2870373_2871264_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP014176.1\|WP_039632203.1\|2883050_2883803_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632223.1\|2864962_2866189_-\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235976
NZ_CP014176.1\|WP_039632198.1\|2886448_2886769_-\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_CP014176.1\|WP_080618974.1\|2869444_2870029_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277316
NZ_CP014176.1\|WP_145953069.1\|2866428_2867283_-\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NZ_CP014176.1\|WP_069187799.1\|2868680_2869307_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224665
NZ_CP014176.1\|WP_039632221.1\|2867406_2867889_-\|energy-coupling-factor-transporter-S-component-ThiW	unknown	unknown	gnl\|CDD\|370540
NZ_CP014176.1\|WP_039632227.1\|2862347_2863517_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341459

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039632202.1\|2883970_2884435_-\|transcription-elongation-factor-GreA	gnl\|CDD\|273638	TIGR01462, Transcription_elongation_factor_GreA, transcription elongation factor GreA. The GreA and GreB transcription elongation factors enable to continuation of RNA transcription past template-encoded arresting sites. Among the Proteobacteria, distinct clades of GreA and GreB are found. GreA differs functionally in that it releases smaller oligonucleotides. Because members of the family outside the Proteobacteria resemble GreA more closely than GreB, the GreB clade (TIGR01461) forms a plausible outgroup and the remainder of the GreA/B family, included in this model, is designated GreA. In the Chlamydias and some spirochetes, the region described by this model is found as the C-terminal region of a much larger protein. [Transcription, Transcription factors].	3.03456e-42
NZ_CP014176.1\|WP_039632225.1\|2864101_2864827_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	1.38257e-97
NZ_CP014176.1\|WP_052268039.1\|2880128_2881310_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341135	cd17246, RMtype1_S_SonII-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2. This model contains Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2 and similar TRD-CR's. S.SonII recognizes 5'... GTCANNNNNNRTCA ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases. S.SonII TRD1-CR1 does not belong to this subfamily.	4.8529e-70
NZ_CP014176.1\|WP_039632205.1\|2881290_2882775_-\|SAM-dependent-DNA-methyltransferase	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.59496e-69
NZ_CP014176.1\|WP_039632200.1\|2884569_2885529_-\|tRNA-dihydrouridine-synthase-family-protein	gnl\|CDD\|239200	cd02801, DUS_like_FMN, Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present.	1.11549e-59
NZ_CP014176.1\|WP_039632209.1\|2875596_2878944_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_CP014176.1\|WP_039632207.1\|2879054_2879915_-\|DUF4351-domain-containing-protein	gnl\|CDD\|316753	pfam14261, DUF4351, Domain of unknown function (DUF4351). This domain is found in bacteria, and is approximately 60 amino acids in length.	4.53505e-09
NZ_CP014176.1\|WP_039632221.1\|2867406_2867889_-\|energy-coupling-factor-transporter-S-component-ThiW	gnl\|CDD\|370540	pfam09512, ThiW, Thiamine-precursor transporter protein (ThiW). Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.	2.04223e-51
NZ_CP014176.1\|WP_039632213.1\|2873235_2873577_-\|alkylphosphonate-utilization-protein	gnl\|CDD\|225380	COG2824, PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism].	5.08375e-63
NZ_CP014176.1\|WP_039632219.1\|2868246_2868651_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	1.85535e-06
NZ_CP014176.1\|WP_039632217.1\|2870373_2871264_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.71071e-54
NZ_CP014176.1\|WP_039632223.1\|2864962_2866189_-\|malate-dehydrogenase	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP014176.1\|WP_039632198.1\|2886448_2886769_-\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	4.15966e-46
NZ_CP014176.1\|WP_080618974.1\|2869444_2870029_-\|metallophosphoesterase	gnl\|CDD\|277316	cd00144, MPP_PPP_family, phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain. The PPP (phosphoprotein phosphatase) family is one of two known protein phosphatase families specific for serine and threonine. This family includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.7794e-16
NZ_CP014176.1\|WP_145953069.1\|2866428_2867283_-\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	9.3832e-109
NZ_CP014176.1\|WP_069187799.1\|2868680_2869307_-\|hypothetical-protein	gnl\|CDD\|224665	COG1751, COG1751, Uncharacterized conserved protein [Function unknown].	1.741e-67
NZ_CP014176.1\|WP_039632227.1\|2862347_2863517_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341459	cd08180, PDD, 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism. 1,3-propanediol dehydrogenase (PPD) plays a role in glycerol metabolism of some bacteria in anaerobic conditions. In this degradation pathway, glycerol is converted in a two-step process to 1,3-propanediol (1,3-PD) which is then excreted into the extracellular medium. The first reaction involves the transformation of glycerol into 3-hydroxypropionaldehyde (3-HPA) by a coenzyme B-12-dependent dehydratase. The second reaction involves the dismutation of the 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol by the NADH-linked 1,3-propanediol dehydrogenase (PPD). The enzyme requires iron ion for its function. Because many genes in this pathway are present in the propanediol utilization (pdu) operon, they are also named pdu genes. PPD is a member of the iron-containing alcohol dehydrogenase superfamily. The PPD structure has a dehydroquinate synthase-like fold.	0

>NZ_CP014176.1|WP_039632215.1|2871596_2872298_-|hypothetical-protein
MNRAILSVDWDYFVKIIPQWCGSYIENQRGLLSAWYRRYIEEGIKGVNLEEEIKVSKDALNFWDEIRNKFNFSEDIKVYVSDSHKYSYDISKYYNCDEVFLFDAHSDLGYGGLASLRFELNCANWLGKLFKNNIIKKANIFYSPYTLEKPEDFEELNNNYEIDYLDFSKFNEKNNIDVIHICRSGGWTPPWLDNDFYKFIKALNLPYKELESLKRIWRPKELTFSEEINYLIS
>NZ_CP014176.1|WP_039632217.1|2870373_2871264_-|GGDEF-domain-containing-protein
MKEPITIEVLKEKLDFFRTIYDSIRIIDPVKKSVMDYKESNIKETNQICYKYWSSQKICDNCIAMRAYIENDTFMKLENTAEKLFMVTAIPTEIQQHKIVLELFKDVTNTMMVGSGEYESGRSLKNSLVDMNNMVVKDDLTNIFNRRYISERLPADIIKSVIDRKPLSVLIADIDKFKEINDTFGHIVGDFVIKEIANILLGCIRGDIDWIARYGGDEFLICLNNTSNNSAYSIAERMRVKIEEKIIQIEDKKIEIFASFGIFTMFKEQLTSEEIIALADRNLYEAKKRGRNNVVK
>NZ_CP014176.1|WP_080618974.1|2869444_2870029_-|metallophosphoesterase
MEEHWNNKDELLIQVGDLIDRGSFSPRTVEYCRGLKKQFPSNVVFLKGNHEFEIIYHFLNEPNENWLRQCGYETLEQYKSENKNPIEDVNWFLTLPLYWENENIFISHAGLSEIALNCFEETDSNGVLLNRGKVKNINKLQIIGHTPCENSEPIYNEEENSLNIDTGAGYKDGVLTGVKLNEKGEILKIIKINT
>NZ_CP014176.1|WP_069187799.1|2868680_2869307_-|hypothetical-protein
MYFEKAGRENTIKTIELAVKTAKERGIKNIVVASNAGDTALLLKDSGLNAVVVTHVNGFREAGIQEISEARMEELKSCGFKVYTSTHVLSGAERALSTKFGGISPVEVMAYSLRMFGQGVKVAVEVATMALDGGTIPYGEDIISIGGSGKGADTAIILTPAHGSAILDTKIKEIICKHIIFNKFLYLIKFTKCNKCYRNICLKVIELC
>NZ_CP014176.1|WP_039632219.1|2868246_2868651_-|hemerythrin-domain-containing-protein
MANINNLTRQHIEILEMIYDIKELINKDLEVECSEIAKNINLLSGKLRIHLESEDKFLYPNLLKNENEKIKNIAKCYIDEMGDILSIFNNYKNQFNTRSKIINNKDKFIINTKEVFDKIEKRMESEDRELYKLL
>NZ_CP014176.1|WP_039632221.1|2867406_2867889_-|energy-coupling-factor-transporter-S-component-ThiW
MKTKKIVLSAMFIAIGVLGSSIYIPMGVAKCFPVQHAINVVSAIALGPVNGVAIAFCISLLRNILGTGTLLAFSGSMVGAALAGSFYKKTKKNFMAVMGEIIGTGILGSLMSFPIAKLIMGKSVGAFVFIIPFGVSTVVGSVIAYLLVMVFEKTKVMKTI
>NZ_CP014176.1|WP_145953069.1|2866428_2867283_-|hydroxyethylthiazole-kinase
MSEYKHMEDALEKGGTILGLIKDKKPLIHQITNYVSCNDCANITLALGASPIMSEDAEEVEEIVSKSSALLINIGMLTKDTLESMILAGKKANSLNIPVVLDPVGVAASNFRKSSIEKLLKEINFSVIKGNLSEIKTLCGLKTNSKGVDSEENEEGIDYIKEGKALAEALSYKLNSVICITGKIDIICYKDICYAVENGHSIMSKVTAMGCMMGAVIATLASITKEHLISTLIAVTLLGICGELAEREIKKGIEGSGTFKIKFLDQIYNFSEEKLYTNQRIYKV
>NZ_CP014176.1|WP_039632223.1|2864962_2866189_-|malate-dehydrogenase
MNLKETALKFHKDFQGKIALHCKVPVNNKEDMTLAYTPGVAEPCMEINKDYDKVYDYTSKGNWVAVVTNGTAVLGLGDIGAAAGLPVMEGKSVLFKAFAGVDAFPICLDTKDSKKIIETVKLMESSFGGVNLEDIKAPECFEIEEELKKICNIPIFHDDQHGTAVVSLACLFNAVKLANKKMEDIKVVINGAGAAGIAIAKLLIRLNVKDVILCDTQGAIYEGRTVKMNKYKEEMAKISNKDKEQGTLEEVLKGKDVFLGVSVANCVTSEMVKSMNKDAIVMAMANPNPEILPNIAKEAGAKVVCTGRSDFPNQVNNVLAFPGIFRGALDVRASEINDEMKIAAARAIAEIITDEELNEEYVIPEPFDLRIAPKVAEYVARAAIETKVNRIDVKPEEIYEKTKRIIEK
>NZ_CP014176.1|WP_039632225.1|2864101_2864827_+|glycerophosphodiester-phosphodiesterase
MIINFAHRGASMYYPENTMVAFEKAIEMGCTGIETDVQMTKDGVLVLIHDEYLDRTTNGIGLVKNYTYNELRKLDAGSFKDRAFSKCKIPSIEELIECTKNKNIKINFEIKNSIIFYKNIEEKLLFHIMKENIEDKVILSSFNHASMNKCKKLNSNIRTGLLFEKKIKDVDEYLYPIKPNALHLPYKGLRKELIEKAHKNNLVINIYTVNDVNYMRKLIDMKVDGIITNCPDLLKEVLIEY
>NZ_CP014176.1|WP_039632227.1|2862347_2863517_-|iron-containing-alcohol-dehydrogenase
MSNFNMGPKVHFGVGELKELRNINCKRAFIVTDPFMVTSGFINRVTEHLEAASIAYEIFSEIVPDPPLEVVSKGIKAMDKFNPDALIAMGGGSAIDASKAISYFRALVKKGISPEIEVKKPLFIAIPTTSGTGSEVTAFSVITDKKFNVKYPLVDEDMVPDMAILDAELVKSVPPAITADTGIDVLTHAIEAYVSTKNSDFTDALAEKAIKLVFKYLPKAYKDGSDLEAREKMHNASCIAGIAFTNSSLGVNHSMAHILGGRFHIPHGKANALVLPYVIEYNADIKSIGRNEYTKAAERYAEIARFLGLTSSNSVREGVKALINGVKNLIRSLGIPNKIKDLNISSSEFDKNLTDMAEIALKDGCTPTNPREPKVEELKELFKKVYNGM
>NZ_CP014176.1|WP_039632213.1|2873235_2873577_-|alkylphosphonate-utilization-protein
MLDLPNCPKCNSEYTYEDRGLFVCPECVHEWTLELEKENTEDKKVIKDANGNVLNDGDSVTVIKDLKVKGSSSVIKIGTKVKNIRLVDGDHDIDCKIDGFGAMKLKSEFVKKI
>NZ_CP014176.1|WP_039632211.1|2874728_2875010_-|hypothetical-protein
MDIGKIIDKKREEKGYLKKDLAGIADINYKSFCDKLNRNSIQWDELFRLTYILNINLEELKERYVKEHMAKNTETISWDLEDNKYRTIKTGRF
>NZ_CP014176.1|WP_039632209.1|2875596_2878944_-|DEAD/DEAH-box-helicase-family-protein
MCTNFEFLKVKKEFTSFSDACIEAEKSILVSPATTAILSRRALELAVKWVYSFDEELGIPYRDNISSLIHNGSFIELIDSEMLPLLKFVINLGNVAVHTNKTVTREEAILSLHNLYQFINWIDYCYGDDYKEKKFNENSLLQGEEKRVRPEELKDLYDKLSSKDKKLEEIIKENEELRKVITQKRKENIENYDFNIEEISEFDTRKIYIDVELKLAGWDFNKDIGEEIELFGMPNNAEKGYADYVLYGDNGKPLAVVEAKRTSRDAKAGQQQAKLYADCLEKQYNVRPVIFFTNGLETYIWDDYNGYSERRIYGFFKKDELQLMIDRRTQKKTLRNIDIKDEISNRYYQKEAITACCEELERRKRKLLLVMATGTGKTRTAISLVDVLTRHTWVKNILFLADRTALVKQAKKNFSNLLPDLSLCNLLDSKDNPEESRMIFSTYPTMMNAIDDTKAKDGKKLFTCGHFDLIIVDESHRSIYKKYKAVFDYFDAYLIGLTATPKDEVDKNTYGIFDMENGVPTYAYEFDKAVEDEFLVEYETIEVKSKIMEDGIKYDELSDEDKEEYEEKFDKDENIGEEIQSSAINQWLFNANTIDLVLNKLMEKGLRIEGNEKLGKTIIFAKNHKHAEAIKERFDILYPELGSNYAKVIDNQINYVDSLIDDFSGKDKLPQIAISVDMLDTGIDIPEILNLVFFKKIRSKTKFWQMIGRGTRLCEDLLGIGQHKDKFLIFDFCNNFEFFRMNPKGFKGNLGQTLSERIFNLKLDLVKELQDLRYSDEEYVSHRNELLKYLIEDVNNLNEDSFMVKMNLKYVQKYKNKNEWQSLGAVNAKDIKEHIAPLISKLNDDEFAKRFDILMYTIELANLQGNNATRPIKSVIETAESLSKLGTIPQIQQQKYIIDKVRTTEFWEDVDLFELDEVRSALRELLKYLGKTTQKTYYTHFEDMIINEESHGAMYNVNDLKNYRKKVEYYLKEHENELAIYKLKNNKQLTKQDLETLESIMWQELGTKADYEKEFGDMPVNKLVRKMVGLNRNTTNELFSEFLNNENLNIKQIHFVKLIIDYVVKNGFIDDNRILMEDPFRTVGNLSVLFKDNMKEAKSIMGKISQIKENAEKIV
>NZ_CP014176.1|WP_039632207.1|2879054_2879915_-|DUF4351-domain-containing-protein
MKSTNYEDLIIKRAMDLFAEEGLKFFGINKKVKELGPTELVVLETKNMFMDYTFLMEDDTFIHFEFQTTNKGKVDLRRFRAYEALLSHQTGKDAVTYVVYSGNIKNPVNTLETGISEFRVNSISMASKDGDKIYNDIVEKIKSGIDITKQDIISLTFTPIMGGNISTVDKILNAIGIIKDINKDYKHDVESILYAFANKFLSGKDLEKVKEELKMTELGKSLIQEGIEKGKEKGKAELLIKMLMHKFKKVPDEYKEKIKTLSEETIELIATDIFELNSIEELERYF
>NZ_CP014176.1|WP_052268039.1|2880128_2881310_-|restriction-endonuclease-subunit-S
MDIKKIKCSEIIDVRDGTHDSPKYQLKGYPLVTSKNIKGNKIDFNNVNFISEEDYNKINMRSSVHNGDILMPMIGTIGNPVLVDTNEKFAIKNVALFKLSNNNKVDSKYFYYLLTSDIVKNQLENRKRGGTQNFVSLSNIRSLEIPLVAIEKQIFISNILDKAQSLIDKRKAQIEALDELVKSQFIEMFGDNWKEVNLIDYVWLQEGPGVRSIDFTEEGTVLLTGSNINDNEISFGYKSDRYISNELANGKYNHFICDKDDVLVVSSAIAPDKFDKKVVVVKEDKKYCLNTGIIRFKPNSKYLIINYFREFLKTDFFKYQVMKEMRGIAQMHFGPSHLKNMKILLPPIELQNQFSDFVKQVDKLKFEMEKSLKELEDNFNSLMQRAFKGELFN
>NZ_CP014176.1|WP_039632205.1|2881290_2882775_-|SAM-dependent-DNA-methyltransferase
MITGELKSKIDRIWETFWTGGITNPLEVIEQFTYFLFIKDLDDNEILAESDAGLLGIPFEGMFPSGKQYLRWSKFKNEEAGEMYRIVSEEVFPFIKNIHGDNQSAYSKYMSDAMFKIPTPLMLSKIVDAIDSLEMDDKDTKGDLYEYLLSKVATAGTNGQFRTPRHIIKMMAELMKPTPEDIIVDPAMGSAGFLVGAEEYLRTNHNDLFFVQGLKEHFNNKMFNGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSETNKDSEKYTLVLANPPFKGSLDYEAVSADLLKASKTKKTELLFLALFLRILKTGGRCASIVPDGVLFGSTKGHRDIRKEIIDNNKLEAIINMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYSLDDKRNPIEDNDISDIIERFSNLDKEEDRKRTEQSFFVPVDEIRENDYDLSINKYKEIEYDEVVYDEPKVILERVKKLEEEIAEGIDELEKMIEMGEENGYKKD
>NZ_CP014176.1|WP_039632203.1|2883050_2883803_-|hypothetical-protein
MFYCPYYFFRKNVDNNKVYIIDRKKGDVNGDKVEDTILLIGNKPSGTDSPFVSNIRLVIKDGKTGKEITVPIKENSGYNPTIFLGDFTGDKIKDILVSIDSGGSGGFAFYYIYSFANNQLKLIFDFEKFGEQYTYEVNYKDNYRVEVISKNLKIKYIIDITYKGEEYLNEIYDLNGKLKEPISGFVIPLSNLYPIDFERDGTYELYVFQRIAGRYNADGLGYVQTALNWEKDKFTTLFQNVGIQGKYIGG
>NZ_CP014176.1|WP_039632202.1|2883970_2884435_-|transcription-elongation-factor-GreA
MKNILTQENMDKLKEELEYRMTKKRAEIAKEKLEAAAHGDRSENAEYKEACANYRENDNRIQYLLTMISTASVIDDQNQDKSALGINSKAKIKFIEDEFETDISLVTTMDADPEKMLISVESDLGKALMGKKVGDVAEIDAPGEKYTVEVLEII
>NZ_CP014176.1|WP_039632200.1|2884569_2885529_-|tRNA-dihydrouridine-synthase-family-protein
MKYYLAPMEGITGYIYRNSYEKFFHNIDKYFTPFIVTNKSTNLKTKELRDILPENNKGMNIVPQILTNDSEGFIITARKLQQLGYNEINLNLGCPSGTVVSKNRGSGFLAKREELDIFLDEIFKINDMKISIKTRIGKDSPEEFYELIKIYNKYPIEELIIHPRTQKDFYGNKPNLDVFKDALSLSVNPICYNGDIFTNSDYNRLIKAFPEIKTVMIGRGILANPGLIDEIKNNTNIDKEVLKEFHDEILNKYIELYNEERNTLFRMKELWGYMIYIFSDNKKYAKKIKKAQRGDHYNEAVLSLFREQEIIKGTGLFSN
>NZ_CP014176.1|WP_039632198.1|2886448_2886769_-|putative-heavy-metal-binding-protein
MIVTTTNAIEGKRILEYKGIVFGEVISGVNFIKDFKAGLTNFFGGRSGSYENELIEAREAALRELEERAMAIGGNAVVGVDVDYEVLGQGGSMLMVTVSGTAVLVD

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Crispr_ID: NZ_CP014176_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_5

2888606-2888762

Orphan

III-B

Consensus_repeat	Method
AATTTAAATACATCTTATGTTAAGGTTCAACTA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP014176_5

>merge|NZ_CP014176|5|2888606-2888762|PILER-CR
ACATCTCATGTTAAGGTTCAACTTTGTATTTATAGATATAAACTCAGGGCTGAAAGAATTTAAATACATCTTATGTTAAGGTTCAACTAAAGATGTTAGTGATACAATCAAGAAAGCCATTAAATTTAAATACATCTTATGTTAAGGTTCAACTATT

>NZ_CP014176|5|6|2888606-2888762|PILER-CR
ACATCTCATGTTAAGGTTCAACTTTGTATTTATAG	ATATAAACTCAGGGCTGAAAGAATTTAAATACA
TCTTATGTTAAGGTTCAACTAAAGATGTTAGTGAT	ACAATCAAGAAAGCCATTAAATTTAAATACATC
TTATGTTAAGGTTCAACTATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039632202.1\|2883970_2884435_-\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|273638
NZ_CP014176.1\|WP_039632190.1\|2891436_2892564_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
NZ_CP014176.1\|WP_039632182.1\|2895581_2895866_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632198.1\|2886448_2886769_-\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_CP014176.1\|WP_039632181.1\|2896393_2896972_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NZ_CP014176.1\|WP_039632200.1\|2884569_2885529_-\|tRNA-dihydrouridine-synthase-family-protein	unknown	unknown	gnl\|CDD\|239200
NZ_CP014176.1\|WP_039632196.1\|2887271_2888081_-\|DUF2935-domain-containing-protein	unknown	unknown	gnl\|CDD\|378573
NZ_CP014176.1\|WP_039632192.1\|2890201_2891113_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|379247
NZ_CP014176.1\|WP_039632211.1\|2874728_2875010_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632209.1\|2875596_2878944_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|226581
NZ_CP014176.1\|WP_039632194.1\|2889097_2890186_-\|amidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378910
NZ_CP014176.1\|WP_039632207.1\|2879054_2879915_-\|DUF4351-domain-containing-protein	unknown	unknown	gnl\|CDD\|316753
NZ_CP014176.1\|WP_039632179.1\|2897871_2899026_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NZ_CP014176.1\|WP_039632184.1\|2894465_2895152_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319790
NZ_CP014176.1\|WP_152609368.1\|2892757_2893372_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_160289208.1\|2897482_2897653_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632186.1\|2893758_2894157_-\|hemerythrin-family-protein	unknown	unknown	gnl\|CDD\|274154
NZ_CP014176.1\|WP_039632203.1\|2883050_2883803_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039632205.1\|2881290_2882775_-\|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|223363
NZ_CP014176.1\|WP_052268039.1\|2880128_2881310_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341135

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039632202.1\|2883970_2884435_-\|transcription-elongation-factor-GreA	gnl\|CDD\|273638	TIGR01462, Transcription_elongation_factor_GreA, transcription elongation factor GreA. The GreA and GreB transcription elongation factors enable to continuation of RNA transcription past template-encoded arresting sites. Among the Proteobacteria, distinct clades of GreA and GreB are found. GreA differs functionally in that it releases smaller oligonucleotides. Because members of the family outside the Proteobacteria resemble GreA more closely than GreB, the GreB clade (TIGR01461) forms a plausible outgroup and the remainder of the GreA/B family, included in this model, is designated GreA. In the Chlamydias and some spirochetes, the region described by this model is found as the C-terminal region of a much larger protein. [Transcription, Transcription factors].	3.03456e-42
NZ_CP014176.1\|WP_039632190.1\|2891436_2892564_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	3.63501e-123
NZ_CP014176.1\|WP_039632179.1\|2897871_2899026_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	5.70975e-167
NZ_CP014176.1\|WP_039632205.1\|2881290_2882775_-\|SAM-dependent-DNA-methyltransferase	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.59496e-69
NZ_CP014176.1\|WP_039632181.1\|2896393_2896972_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	8.99331e-07
NZ_CP014176.1\|WP_039632200.1\|2884569_2885529_-\|tRNA-dihydrouridine-synthase-family-protein	gnl\|CDD\|239200	cd02801, DUS_like_FMN, Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present.	1.11549e-59
NZ_CP014176.1\|WP_039632196.1\|2887271_2888081_-\|DUF2935-domain-containing-protein	gnl\|CDD\|378573	pfam11155, DUF2935, Domain of unknown function (DUF2935). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	1.08082e-40
NZ_CP014176.1\|WP_039632192.1\|2890201_2891113_-\|M15-family-metallopeptidase	gnl\|CDD\|379247	pfam13539, Peptidase_M15_4, D-alanyl-D-alanine carboxypeptidase. This family resembles VanY, pfam02557, which is part of the peptidase M15 family.	1.31909e-19
NZ_CP014176.1\|WP_039632209.1\|2875596_2878944_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_CP014176.1\|WP_039632194.1\|2889097_2890186_-\|amidase-domain-containing-protein	gnl\|CDD\|378910	pfam12671, Amidase_6, Putative amidase domain.	8.73965e-54
NZ_CP014176.1\|WP_039632207.1\|2879054_2879915_-\|DUF4351-domain-containing-protein	gnl\|CDD\|316753	pfam14261, DUF4351, Domain of unknown function (DUF4351). This domain is found in bacteria, and is approximately 60 amino acids in length.	4.53505e-09
NZ_CP014176.1\|WP_039632186.1\|2893758_2894157_-\|hemerythrin-family-protein	gnl\|CDD\|274154	TIGR02481, hemeryth_dom, hemerythrin-like metal-binding domain. This model describes both members of the hemerythrin (TIGR00058) family of marine invertebrates and a broader collection of bacterial and archaeal homologs. Many of the latter group are multidomain proteins with signal-transducing domains such as the GGDEF diguanylate cyclase domain (TIGR00254, pfam00990) and methyl-accepting chemotaxis protein signaling domain (pfam00015). Most hemerythrins are oxygen-carriers with a bound non-heme iron, but at least one example is a cadmium-binding protein, apparently with a role in sequestering toxic metals rather than in binding oxygen. Patterns of conserved residues suggest that all prokaryotic instances of this domain bind iron or another heavy metal, but the exact function is unknown. Not surprisingly, the prokaryote with the most instances of this domain is Magnetococcus sp. MC-1, a magnetotactic bacterium.	2.9429e-30
NZ_CP014176.1\|WP_039632184.1\|2894465_2895152_-\|HAD-family-hydrolase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.21926e-19
NZ_CP014176.1\|WP_039632198.1\|2886448_2886769_-\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	4.15966e-46
NZ_CP014176.1\|WP_052268039.1\|2880128_2881310_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341135	cd17246, RMtype1_S_SonII-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2. This model contains Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2 and similar TRD-CR's. S.SonII recognizes 5'... GTCANNNNNNRTCA ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases. S.SonII TRD1-CR1 does not belong to this subfamily.	4.8529e-70

>NZ_CP014176.1|WP_039632196.1|2887271_2888081_-|DUF2935-domain-containing-protein
MKISDIKEMILFEHHFWLQILGDHSRFILNSLSTKEVPFIEQANRFKDLFDNLLKRSRQPLSEEEIFALNNHAYDAAMKIREFKLDILDRQIIDKITISLPPTFINHMVNEVEEYICILTKLIEGSIPNIGSIDLHLLWLPDGAGHASSIASGLDMTEKELIKKSNQYSKEFSNLYLRTIEYNGYTRTGICDFPALNSLNNTADRVMSCFKEFLNELKRGIIEKKILGTIVPLVPDHMFREECYYLTKLSMVSNIKRPECDPTKPRVEN
>NZ_CP014176.1|WP_039632198.1|2886448_2886769_-|putative-heavy-metal-binding-protein
MIVTTTNAIEGKRILEYKGIVFGEVISGVNFIKDFKAGLTNFFGGRSGSYENELIEAREAALRELEERAMAIGGNAVVGVDVDYEVLGQGGSMLMVTVSGTAVLVD
>NZ_CP014176.1|WP_039632200.1|2884569_2885529_-|tRNA-dihydrouridine-synthase-family-protein
MKYYLAPMEGITGYIYRNSYEKFFHNIDKYFTPFIVTNKSTNLKTKELRDILPENNKGMNIVPQILTNDSEGFIITARKLQQLGYNEINLNLGCPSGTVVSKNRGSGFLAKREELDIFLDEIFKINDMKISIKTRIGKDSPEEFYELIKIYNKYPIEELIIHPRTQKDFYGNKPNLDVFKDALSLSVNPICYNGDIFTNSDYNRLIKAFPEIKTVMIGRGILANPGLIDEIKNNTNIDKEVLKEFHDEILNKYIELYNEERNTLFRMKELWGYMIYIFSDNKKYAKKIKKAQRGDHYNEAVLSLFREQEIIKGTGLFSN
>NZ_CP014176.1|WP_039632202.1|2883970_2884435_-|transcription-elongation-factor-GreA
MKNILTQENMDKLKEELEYRMTKKRAEIAKEKLEAAAHGDRSENAEYKEACANYRENDNRIQYLLTMISTASVIDDQNQDKSALGINSKAKIKFIEDEFETDISLVTTMDADPEKMLISVESDLGKALMGKKVGDVAEIDAPGEKYTVEVLEII
>NZ_CP014176.1|WP_039632203.1|2883050_2883803_-|hypothetical-protein
MFYCPYYFFRKNVDNNKVYIIDRKKGDVNGDKVEDTILLIGNKPSGTDSPFVSNIRLVIKDGKTGKEITVPIKENSGYNPTIFLGDFTGDKIKDILVSIDSGGSGGFAFYYIYSFANNQLKLIFDFEKFGEQYTYEVNYKDNYRVEVISKNLKIKYIIDITYKGEEYLNEIYDLNGKLKEPISGFVIPLSNLYPIDFERDGTYELYVFQRIAGRYNADGLGYVQTALNWEKDKFTTLFQNVGIQGKYIGG
>NZ_CP014176.1|WP_039632205.1|2881290_2882775_-|SAM-dependent-DNA-methyltransferase
MITGELKSKIDRIWETFWTGGITNPLEVIEQFTYFLFIKDLDDNEILAESDAGLLGIPFEGMFPSGKQYLRWSKFKNEEAGEMYRIVSEEVFPFIKNIHGDNQSAYSKYMSDAMFKIPTPLMLSKIVDAIDSLEMDDKDTKGDLYEYLLSKVATAGTNGQFRTPRHIIKMMAELMKPTPEDIIVDPAMGSAGFLVGAEEYLRTNHNDLFFVQGLKEHFNNKMFNGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSETNKDSEKYTLVLANPPFKGSLDYEAVSADLLKASKTKKTELLFLALFLRILKTGGRCASIVPDGVLFGSTKGHRDIRKEIIDNNKLEAIINMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYSLDDKRNPIEDNDISDIIERFSNLDKEEDRKRTEQSFFVPVDEIRENDYDLSINKYKEIEYDEVVYDEPKVILERVKKLEEEIAEGIDELEKMIEMGEENGYKKD
>NZ_CP014176.1|WP_052268039.1|2880128_2881310_-|restriction-endonuclease-subunit-S
MDIKKIKCSEIIDVRDGTHDSPKYQLKGYPLVTSKNIKGNKIDFNNVNFISEEDYNKINMRSSVHNGDILMPMIGTIGNPVLVDTNEKFAIKNVALFKLSNNNKVDSKYFYYLLTSDIVKNQLENRKRGGTQNFVSLSNIRSLEIPLVAIEKQIFISNILDKAQSLIDKRKAQIEALDELVKSQFIEMFGDNWKEVNLIDYVWLQEGPGVRSIDFTEEGTVLLTGSNINDNEISFGYKSDRYISNELANGKYNHFICDKDDVLVVSSAIAPDKFDKKVVVVKEDKKYCLNTGIIRFKPNSKYLIINYFREFLKTDFFKYQVMKEMRGIAQMHFGPSHLKNMKILLPPIELQNQFSDFVKQVDKLKFEMEKSLKELEDNFNSLMQRAFKGELFN
>NZ_CP014176.1|WP_039632207.1|2879054_2879915_-|DUF4351-domain-containing-protein
MKSTNYEDLIIKRAMDLFAEEGLKFFGINKKVKELGPTELVVLETKNMFMDYTFLMEDDTFIHFEFQTTNKGKVDLRRFRAYEALLSHQTGKDAVTYVVYSGNIKNPVNTLETGISEFRVNSISMASKDGDKIYNDIVEKIKSGIDITKQDIISLTFTPIMGGNISTVDKILNAIGIIKDINKDYKHDVESILYAFANKFLSGKDLEKVKEELKMTELGKSLIQEGIEKGKEKGKAELLIKMLMHKFKKVPDEYKEKIKTLSEETIELIATDIFELNSIEELERYF
>NZ_CP014176.1|WP_039632209.1|2875596_2878944_-|DEAD/DEAH-box-helicase-family-protein
MCTNFEFLKVKKEFTSFSDACIEAEKSILVSPATTAILSRRALELAVKWVYSFDEELGIPYRDNISSLIHNGSFIELIDSEMLPLLKFVINLGNVAVHTNKTVTREEAILSLHNLYQFINWIDYCYGDDYKEKKFNENSLLQGEEKRVRPEELKDLYDKLSSKDKKLEEIIKENEELRKVITQKRKENIENYDFNIEEISEFDTRKIYIDVELKLAGWDFNKDIGEEIELFGMPNNAEKGYADYVLYGDNGKPLAVVEAKRTSRDAKAGQQQAKLYADCLEKQYNVRPVIFFTNGLETYIWDDYNGYSERRIYGFFKKDELQLMIDRRTQKKTLRNIDIKDEISNRYYQKEAITACCEELERRKRKLLLVMATGTGKTRTAISLVDVLTRHTWVKNILFLADRTALVKQAKKNFSNLLPDLSLCNLLDSKDNPEESRMIFSTYPTMMNAIDDTKAKDGKKLFTCGHFDLIIVDESHRSIYKKYKAVFDYFDAYLIGLTATPKDEVDKNTYGIFDMENGVPTYAYEFDKAVEDEFLVEYETIEVKSKIMEDGIKYDELSDEDKEEYEEKFDKDENIGEEIQSSAINQWLFNANTIDLVLNKLMEKGLRIEGNEKLGKTIIFAKNHKHAEAIKERFDILYPELGSNYAKVIDNQINYVDSLIDDFSGKDKLPQIAISVDMLDTGIDIPEILNLVFFKKIRSKTKFWQMIGRGTRLCEDLLGIGQHKDKFLIFDFCNNFEFFRMNPKGFKGNLGQTLSERIFNLKLDLVKELQDLRYSDEEYVSHRNELLKYLIEDVNNLNEDSFMVKMNLKYVQKYKNKNEWQSLGAVNAKDIKEHIAPLISKLNDDEFAKRFDILMYTIELANLQGNNATRPIKSVIETAESLSKLGTIPQIQQQKYIIDKVRTTEFWEDVDLFELDEVRSALRELLKYLGKTTQKTYYTHFEDMIINEESHGAMYNVNDLKNYRKKVEYYLKEHENELAIYKLKNNKQLTKQDLETLESIMWQELGTKADYEKEFGDMPVNKLVRKMVGLNRNTTNELFSEFLNNENLNIKQIHFVKLIIDYVVKNGFIDDNRILMEDPFRTVGNLSVLFKDNMKEAKSIMGKISQIKENAEKIV
>NZ_CP014176.1|WP_039632211.1|2874728_2875010_-|hypothetical-protein
MDIGKIIDKKREEKGYLKKDLAGIADINYKSFCDKLNRNSIQWDELFRLTYILNINLEELKERYVKEHMAKNTETISWDLEDNKYRTIKTGRF
>NZ_CP014176.1|WP_039632194.1|2889097_2890186_-|amidase-domain-containing-protein
MRFSSCKKVIILLLLILFSPFNKFYTVKAEEEDVDINQVVERIFKDRSLAILNQDLELIEEFYDTDSKYGRWAYEYQEKKTKYIINWAEKQGVKFTEINPHIVIRKVKGNDDVYSLNILCSMEYKYSYENEPEVSNKSRIGSYHTMTLAKKDGNWLITKEWYNDPFADSLDLENIKSSDIKQHIISQPPRDMSDLNERRVGAIEYAKMYCGSATEPEFQFKYNKKYRNFNYEGGDCANFASQILHEGGKFKKNYTWNYDKGSATGPWVNADKFTHYMLNSGRASVIAKGSYENVYKASYKLLPGDFIAYEKKGDITHISVVTGADSKGYSLVSCHNVDRNDVPWDLGWSDKKIRFWLVRVHY
>NZ_CP014176.1|WP_039632192.1|2890201_2891113_-|M15-family-metallopeptidase
MKKICSFIVAFTLLTSKFYNINAYAQNIDYDTTMKQDLLSLFMAYPEDIIDIEKQDNGLVYLVMKSGNKIVYDDKKEKTQQEKLVNGDLQDMMEQVYPLEKIDDLMEENFDPGRIRVYSLLNEVYGSSREQIEKNLTNVNFAYQNYRFNKNNKAAENLDNVSKKLLILAKTNTKIGSFVNPSNGTFNYRIISGTGRLSPHAYGLAIDIASDKRDYWKWASREQGKARLLQYPDELVKTFEENNFVWGGKWGHFDILHFEYRPEIILKARYFGDNKGEKANWYEGVPCDETIKIYIEKIDKALS
>NZ_CP014176.1|WP_039632190.1|2891436_2892564_-|aminopeptidase
MGDIRLNKLAKLLVNYSTKVKKGDFVFISCNDVAKPWVVEVAKEAIKAGAHVEYSLDSEDVNETILKDSNEEQLLEGSHLNKNMLSKADVWLTAWGTRNTKMNSNVDPKKLQLKSRGAASWRKIYSERMGDGSLRWCGTQFPTYADAQEASMSLNEYEDFVYGAGLLDMEDPVSEWKKISAYQDRWVKYLNTKKELHFLSEGTDIKVKVEGKKWINCDGKANFPDGEIFTSPIENGIDGYITFSFPGIYMGKEIEGIRLEVTEGKVVKAIAQKGEDLLKMLIETDEGASYFGEVAIGTNYGIKKFTKNMLFDEKIGGTIHMAIGDSDPEAGGLNRSSIHWDMLCDMRNGGKIYADGELFYENGQFKEEILKKYNL
>NZ_CP014176.1|WP_152609368.1|2892757_2893372_-|hypothetical-protein
MIKYICIMLCFLICLFAEKNPFNKLDISLLKAGLFITLFADLFLTVFNYYTLGVALFCVVQILYSIRYEALKISETSLKFIIIFLSIMFIYLIVNLFIIKIDVLFAVVLFYAICLIISVRKAIKVCKNNLYPHPNKYMIAYGMILFILCDINVALYNVTEVTGISWTFIDIVHNISGLSIWLFYVPSQLLLSLSGYNFSLKKKH
>NZ_CP014176.1|WP_039632186.1|2893758_2894157_-|hemerythrin-family-protein
MNSWKDEYITGVELIDEQHKKLIEIADDLYKLLKNQFITDKYDRIVQILNDLKDYAVFHFKSEEEYMLSIGYKKYLSHKVEHDDFIAKINSFDLKEIDESQQRYLIEILEFVIKWIDGHILKRDKLIALEQN
>NZ_CP014176.1|WP_039632184.1|2894465_2895152_-|HAD-family-hydrolase
MNNNISVVFFDLFFTLVTPKYNDLRNENDILRITKTEWEKYAEDNELYIKRATGHEKSPQKIIEGIVEKMQIDVKECDKIEILKLREERFKKSLIDVDTVILEVLSDIKKNGKKICLLSNADIIDVMHWGKSPLNGLFDDRIFSYEVGYLKPQTEIYSIALKKMNVNPKECIFIGDGGSDELKGAKELGIKTILTEYLLKRDEEQHNAIKKFADYCIKDFKEIKSILF
>NZ_CP014176.1|WP_039632182.1|2895581_2895866_-|hypothetical-protein
MKGKRIKTLLLTGAVLLTATGFMACGQKTEETPGTKVEDKKVDENKDSSKEENKDDKKEENKEESKEDKKEDNKQDNKEENKDQSADQSKEEKK
>NZ_CP014176.1|WP_039632181.1|2896393_2896972_-|GNAT-family-N-acetyltransferase
MKKLIKQLSTDNLEDFFTLFSNDKCESCQCTFYFSANNIDNWIKMTIEEAKKLRINITSKCHDGYIYYMDDEPVAWCQCVHPKDVPYLQNLLSLRSNENVRIISCFFIKKEYRGKGIQKELLQKVLFQCKDEGVEVIYSIPVHDNFLKSIPEKQKNEKLHTGYKALFEQLDFICIGDNRRYYFMEKNLKENR
>NZ_CP014176.1|WP_160289208.1|2897482_2897653_-|hypothetical-protein
MKKYKYIARLAGTISMLLMMYLLFSKLENDKDAWIIIGLYIISIAAIEVENYLKNH
>NZ_CP014176.1|WP_039632179.1|2897871_2899026_-|N-acetylglucosamine-6-phosphate-deacetylase
MSTLITNIRLITPNSVEKGYGVVFNEGKIIDIDLEENINLELISKVINGDGRFLSPGFIDIHNHGNTGHDIMDSAEETLDRIGEFHIKNGVTSYLGTIITSSYNNIITSIKNITDYKNKKTLSQLLGIHLEGPFFSILRKGAQPEKYIKEPDIEIVKDFVELAKNKLKMVSIAPEFNEAIEIISYLKEKNITIAMAHSNATFDEAKRGINHGVTVATHLFNGMREFNHREPGIIGAALTDDRVYCELIYDRIHLHDETVKITLKTKGVDKIVLVSDAMRAAGLEDGEYELGGQKVIVNNGAARLENGGLAGSTLNLKDAVYNMISMLNIPIQDAVRMASLSPAKAIGVSKHKGSIEIGKDADMLLFDDDINISSVFISGNCVSF

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Crispr_ID: NZ_CP014176_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_6

3494461-3494565

Orphan

Consensus_repeat	Method
TCATACTAATCATATATGTATTATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014176_6

>merge|NZ_CP014176|6|3494461-3494565|CRISPRCasFinder
TCATACTAATCATATATGTATTATAAAAATGAATTTTGAAAACCTATTGACTTTTCATCTTTACAGAGCTACAATCTTATTCATACTAAACATATATGTATTATA

>NZ_CP014176|6|5|3494461-3494565|CRISPRCasFinder
TCATACTAATCATATATGTATTATA	AAAATGAATTTTGAAAACCTATTGACTTTTCATCTTTACAGAGCTACAATCTTAT
TCATACTAAACATATATGTATTATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039633643.1\|3486069_3487794_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP014176.1\|WP_039633634.1\|3494591_3495251_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP014176.1\|WP_039633626.1\|3499229_3499790_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|376405
NZ_CP014176.1\|WP_039633635.1\|3493944_3494391_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP014176.1\|WP_039633631.1\|3496679_3497525_+\|cysteine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270412
NZ_CP014176.1\|WP_039633620.1\|3502885_3503794_-\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NZ_CP014176.1\|WP_039633647.1\|3482784_3484158_-\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NZ_CP014176.1\|WP_039633632.1\|3495921_3496680_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP014176.1\|WP_039633639.1\|3489809_3490790_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NZ_CP014176.1\|WP_039633624.1\|3500675_3501155_-\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|214874
NZ_CP014176.1\|WP_039633629.1\|3498015_3498558_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039633633.1\|3495231_3495909_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP014176.1\|WP_039633653.1\|3480438_3481059_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|239323
NZ_CP014176.1\|WP_039633649.1\|3481851_3482280_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP014176.1\|WP_039633637.1\|3491216_3493097_-\|molecular-chaperone-HtpG	unknown	unknown	gnl\|CDD\|235366
NZ_CP014176.1\|WP_039633641.1\|3487795_3489541_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP014176.1\|WP_039633651.1\|3481081_3481717_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225462
NZ_CP014176.1\|WP_039633645.1\|3484179_3485250_-\|methylcobamide--CoM-methyltransferase	unknown	unknown	gnl\|CDD\|376493
NZ_CP014176.1\|WP_039633622.1\|3501761_3502553_+\|SDR-family-oxidoreductase-UcpA	unknown	unknown	gnl\|CDD\|181305
NZ_CP014176.1\|WP_039633627.1\|3498774_3499095_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367272

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039633643.1\|3486069_3487794_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.89085e-130
NZ_CP014176.1\|WP_039633634.1\|3494591_3495251_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.341e-59
NZ_CP014176.1\|WP_039633626.1\|3499229_3499790_-\|nitroreductase-family-protein	gnl\|CDD\|376405	pfam00881, Nitroreductase, Nitroreductase family. The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	2.75265e-36
NZ_CP014176.1\|WP_039633635.1\|3493944_3494391_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	2.77745e-30
NZ_CP014176.1\|WP_039633631.1\|3496679_3497525_+\|cysteine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270412	cd13694, PBP2_Cysteine, Substrate binding domain of ABC cysteine transporter; the type 2 periplasmic binding protein fold. This subfamily comprises of the periplasmic-binding protein component of ABC transporter specific for cysteine and its closely related proteins. The cysteine-binding domains belong to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.56901e-128
NZ_CP014176.1\|WP_039633620.1\|3502885_3503794_-\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	8.0498e-148
NZ_CP014176.1\|WP_039633647.1\|3482784_3484158_-\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	6.17024e-81
NZ_CP014176.1\|WP_039633632.1\|3495921_3496680_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.63654e-144
NZ_CP014176.1\|WP_039633639.1\|3489809_3490790_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.03081e-30
NZ_CP014176.1\|WP_039633624.1\|3500675_3501155_-\|GyrI-like-domain-containing-protein	gnl\|CDD\|214874	smart00871, AraC_E_bind, Bacterial transcription activator, effector binding domain. This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.	1.17937e-18
NZ_CP014176.1\|WP_039633633.1\|3495231_3495909_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	9.09584e-63
NZ_CP014176.1\|WP_039633653.1\|3480438_3481059_-\|DsbA-family-protein	gnl\|CDD\|239323	cd03025, DsbA_FrnE_like, DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	2.137e-44
NZ_CP014176.1\|WP_039633649.1\|3481851_3482280_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	2.97667e-30
NZ_CP014176.1\|WP_039633637.1\|3491216_3493097_-\|molecular-chaperone-HtpG	gnl\|CDD\|235366	PRK05218, PRK05218, heat shock protein 90; Provisional.	0
NZ_CP014176.1\|WP_039633641.1\|3487795_3489541_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.60352e-146
NZ_CP014176.1\|WP_039633651.1\|3481081_3481717_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	2.01676e-86
NZ_CP014176.1\|WP_039633645.1\|3484179_3485250_-\|methylcobamide--CoM-methyltransferase	gnl\|CDD\|376493	pfam01208, URO-D, Uroporphyrinogen decarboxylase (URO-D).	2.36892e-99
NZ_CP014176.1\|WP_039633622.1\|3501761_3502553_+\|SDR-family-oxidoreductase-UcpA	gnl\|CDD\|181305	PRK08226, PRK08226, SDR family oxidoreductase UcpA.	2.3678e-152
NZ_CP014176.1\|WP_039633627.1\|3498774_3499095_+\|hypothetical-protein	gnl\|CDD\|367272	pfam02956, TT_ORF1, TT viral orf 1. TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.	0.0068303

>NZ_CP014176.1|WP_039633635.1|3493944_3494391_-|Rrf2-family-transcriptional-regulator
MRISAKGRYGLAAVIYMAQLHQNGEYITIVKISEALGLSKIYLEQTFSLLKRAEIVTSIKGAQGGYRLTRMPRYITVFEVLSAIETSLFEKTEETVENKVSALESAMQSFVFEPLDNAIETSLKKITLYELANEYEKQREDNDFMFFI
>NZ_CP014176.1|WP_039633637.1|3491216_3493097_-|molecular-chaperone-HtpG
METKQFKAESKRLLDLMINSIYTHREIFLRELISNASDAIDKIYYKALMDESLTFEKDDYYIKVASDKTTRTVRISDTGIGMTKEELDDNLGVIAKSGSLQFKKENELKDGYDIIGQFGVGFYSAFLVADTVTVISKAFGSDEAYKWESKGIDGYTIEPCEKDSIGTEIILRIKENTEDENFDEYLEEYKLQSIIKKYSDFIRYPIKMDITREKLKEGTENEYEEYLEEQIVNSMVPIWRKNKNELTKEDYDNFYSEKHYGFDKPIKHIHTSVDGAVSYNAILFIPEKTPYDFYTKEYEKGLELYSNGVLIMNKCGDLLPDYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELENILKNERDKYEEFYKSFGTQLKYGVYSDFGSNKDILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAAGESNERIEKLPQTEIVLDKGYEILYFTEDVDEFAIRMLMKYNDKEFKSVSSGDLGIEMEENEKSASSDDKDNKELFEHMKDILSDKVKDVRESKRLKNHPVCLSNDGELSIEMEKILNAMPNNENIKADKILEINTNHDVFKSLKEAYESDKDKLKLYTDLLYNQALLIEGLTIADPVEFTNNICKIMI
>NZ_CP014176.1|WP_039633639.1|3489809_3490790_-|helix-turn-helix-domain-containing-protein
MEIKKDIVDIYYKHVEAKYCCKTSDELLGKKYVIGKQFGVGNFSRMRIEDGLEISKIDIDYKMEMAFNNREFDGDILELGYCYNGNMKIFSMPDNKKYTLEAGNMFIYKTLNDVDYFKFRHNKCKIISIQMNFNTIKSAINPIWEDKVIIDWEENINNIFKENILVIEEASYDIKKIAEQIEFISIKDIMSYMNLKLKTIEFLATVLEEKSNKRVLENSKDRRTEIVTMAKDIINKNLQNSPSVKELADSLNISLYKLQEGFKNATGYTVYEYIQKLKIEKAKHLLKNTNMSIIEIANEVGYENPSKFANLFKRYNNITPLKYRKL
>NZ_CP014176.1|WP_039633641.1|3487795_3489541_-|ABC-transporter-ATP-binding-protein
MRKKSNFAFLLEVSGKEKNKLYISAIFSVISSLLAIAPYILMYNIILEFFKVEMNYEKIRYLAIVVGIVVVVRMIIFLASGVFSHVAAFTILYELRMKAVNHISKLNMGFFTEHTIGEVKKIINEDIEKLENFIAHQIPDLASAIVTPIIVISYLMYLNWRLALVLFIPIILAFISQMAMFKGMKKRMVKYHHLLQRLNSTIIQYINGINIMKAFNLSAKSFKNYKDVIEEYADYWIDVTMKSAPLYGIFLVLIDSGLLFMIPIGGIMFLNRSINASTYILFLILSANFLASFKQLLEFGGTFSMLLEGAGRVRSIIEQEPQMSGSKIIDKNSKGKIEFNNVTFKYDKKEIIKNLSLTIEPKNVVALVGPSGSGKTTLAQLLGRFWDIQKGSITIDGIDIREVKMEELMDKISFVFQNIFMLQDTILENIKMGLNKSDEEVVEAAKKAQIHDFIMTLPKGYNTSLGEDGVKLSGGEKQRISIARAILKDSPIVVLDEVTSYSDVENEGKIQEALRTLLKNKTAIIIAHRLYTIKNADKIIVLKEGKILEQGTHSSLMKKNGLYRYLWDMYDYEAIESERGA
>NZ_CP014176.1|WP_039633643.1|3486069_3487794_-|ABC-transporter-ATP-binding-protein
MLTDIKKLLGEESKKLRKPIILLTIDTLFHMFFYSMLYFVLLDLIKEDLNFLKIKKYSIMMVVAFITRALVNAKGYTGIQAKGARAIENMRISLGDHIRNINLGFFNKNSIGSLSNIMTNDLQDFENVITHSTSDLIKTVFLSVYLLIMTFFIDLQLGLIQLIVVFIAMPIIYVGGKKVTTIGNQKKKVMNEVISRLVEYINGIQVFKSYNLVGEKFQRLEKSFSDFKKESIRTEVAIVPFVLIFQIIVDLSFPILLLMVTTKFGAGSIGKIEFLTFIIINIALTNVLRGFGAQYGVFRYFKLASQKLIDTYNQPEMSYKYENLDFDNYDIEFENVDFKYEKGENTIDNLSFKAKEGTMTALIGPSGSGKTTVISLIARFWDVNNGSIRIGGRDIKDIKPDLLLKHISMVFQEVYLLNDTIYNNIKLGNLKATKEEVIRAAKIANCHEFIEKLDNKYDSLIGEGGSTLSGGEKQRISIARAILKDAPIILLDEATASLDADNELEIRKAIKKLTTNKTVIVIAHRLNTIKDADQIIVLNEGSLEERGNHKQLMENKKRYYNMYNEMEKAKNWAI
>NZ_CP014176.1|WP_039633645.1|3484179_3485250_-|methylcobamide--CoM-methyltransferase
MRKEEMTPRERMDAFAKGEEIDRVICIPDMGVTMAPFIGVTAREYYHSAELMANLEIALFTRLGHDSVGISTSLRGVAEAMGSKVGYPDYGISYLLEPAIKSVDQIESLKVVNPLKDGKLPILIEALRLTRDALIKEVDVGAAMSGPFSVAASVVGTENLLKWMIRCPKKVHTLMEIVSESNNRYIEEVAKLGLSIGFADPVSSNSLISPKQFREFSLPYLQKNVNKIKEKTGSAPSIHICGKSKEIWEDVVSTGISNFSIDNIEDLEEAKEVMGDRVIITGNVPPVDVIHKGTREDIFKSVKECIKKGYDSKKGYILSTGCQIPMNTPIEKIDMFMEAAKTYGKYPIDLNLLMKD
>NZ_CP014176.1|WP_039633647.1|3482784_3484158_-|Na+/H+-antiporter-NhaC-family-protein
MKNLNEKKGNGLALLPFGIFIFVYLSSGIILQAQGVEMAFYQFPAPIAALIGIIFAFILTKGSLDDKFNIFIKGCGDENIITMCIIYLLAGAFSTVSSTMGGVESTVNLGLTLIPANFITVGIFIVSAFISISTGTSVGTVVAVAPIAVELVEKAGLSLPLALGALVGGAIFGDNLSIISDTTIAATKTQGISMRDKFKANMGFALPAALVTIVLLLIFGKPVNTPEIQEYSFNIIKIVPYAFVLVTALTGMNVLVVLTGGIVLSGLIGIYYGSFTLLGLSQEIYSGFTGMFDIFLLSLLTGGLANMVSNAGGLDWLLYKVKRKIKGKKSAQLGISALVALTDIATANNTVSIIVNGQLAKEISKEYEVDPRKTASLLDTFSCIMQGLIPYGAQLLIAASFTNGLISPVQIVPYIWYCMILAVFAILSIFTPFGNRYLIKNSWNFEKSTPMDEVASE
>NZ_CP014176.1|WP_039633649.1|3481851_3482280_-|Rrf2-family-transcriptional-regulator
MKISSRFSVAVHILSMLSMEKDNLCTSEWIAGSVNTNPVIIRRVTGMLKKAGIVNVNPGSGGAYLLRPIESITLLDIYKAVEVVEEGQLFQIHENPNPKCPIGANIQLVLEIILLKAQGAMEDVLRNVTMKDIVEGLLEKIK
>NZ_CP014176.1|WP_039633651.1|3481081_3481717_-|NAD(P)-dependent-oxidoreductase
MKIALIGANGNVGKVILKEALLRGHQVTGIVHNISKVESIQDNLKFIEGDIFDEERLSKAIEGNDIVISAFGPKHGEEKSLVDATKSLINAVKKAGVPRLLSMGGAGSLLVEGGIKLVETKDFPSDWKPIALAHGEALEQYKQEKNLNWTNLSPAAFIEPGKRTGVYRTSEDYLVVDEKGDSRISFEDFAFAMLDEVEEPKFSRRRFTVGY
>NZ_CP014176.1|WP_039633653.1|3480438_3481059_-|DsbA-family-protein
MKTKIYYVMDIMCGWCYGFSDVITKIHEKYKEVYDFNILPGGMWIGDNVKTMNHSLGDYIKGHNRRIEELTGRKFGEGFNKNILENNNIVLDSFPGAKAVVLIQRLKKDIAFNFLKKIQEALFIEGKDTNNLETYTEIAESFGISKEEFEKEFLSENLAEETFKYFNMVSEMGVASFPTVIAVEGDNGRIISQGYTNFEELDKILS
>NZ_CP014176.1|WP_039633634.1|3494591_3495251_+|amino-acid-ABC-transporter-permease
MDIDFILKNIPLYIKATQLTLTLAFWGVVLSVLIGFICSLIIYYKVKVLRHIVSGYIELSRNTPLLIQLFFLYYGLPKMGIKLEAYTCAVISLAFLGGSYMAEAFRSGFEAVNTIQIESGLSIGLTKGQLIRYVILPQAFTVAIPALGANAIFILKETSIVSAIALADLMFVTKDLIGMYYKTTEALVMLVVAYLIILLPLSLLLTLIERRVRYAELGN
>NZ_CP014176.1|WP_039633633.1|3495231_3495909_+|amino-acid-ABC-transporter-permease
MQSLGINVFFQGTNLSRLFGGLWVTARIALISISISLILGVILGILMTSNNKLIRFILRIYLEAVRIIPILVWLFLFYFGLTKALNIHLDGELVSILVFTLWGSAEMGDIVRGAITSLPKHQKESGKAIGLTDVQIYFYIIIPQALRRLIPAAINLATRMIKTTSLVVLIGVVEVLKVGQQIIEASIIKNPSASFWVYGFIFFLYFIICYPISLFSKTLEKKWQN
>NZ_CP014176.1|WP_039633632.1|3495921_3496680_+|amino-acid-ABC-transporter-ATP-binding-protein
MTSQNKLLEIQNLNKQYDGTKALSDISFDVHKGEVVVILGPSGCGKSTLLRCINGLEEIQSGQIKLDGQVINKDSTKWHSIRERIGMVFQNYDLFPHMTIMENILLGPLKVQKRDKSEVTNQALKLLKRVGLLDKKDAYPRQLSGGQKQRIAIVRSLCMNPEIMLFDEVTASLDPEMVREILDVMLELAEEGMTMIIVTHEMEFAKAVANRIIFIDKGKITEESTAEEFFNNPKTERAKGFLNIFNFERGAL
>NZ_CP014176.1|WP_039633631.1|3496679_3497525_+|cysteine-ABC-transporter-substrate-binding-protein
MKKSNKILYILSTLILVMGILAGCSNSNTATGIEQIKKNDKVRIGVFSDKPPFGYVDSNGKNQGFDVYIAKQFAKDLLGDENKVEFVLVEAASRVEYLESNKVDILLANFTVTDERKEKVDFANPYMKVSLGVVSPDGAPITNVDQLKGKKLIVNKGTTAEAYFTKNYPDIELLKYEQNTEAFQALKDGRGAALAHDNTLLFSWAKENKGYTTGITSLGNQDTIAPAVKKGNTELLNWINDELAKLGKENFIQKAYDETLLPAYGKDIDPKEVIIEGGKLQ
>NZ_CP014176.1|WP_039633629.1|3498015_3498558_-|hypothetical-protein
MKEWLKSAIRKNKTCQRRGTSFLLLVCIFSILFLISCTSKHSESDTIEGDIVEGYTTIIHDIYSPKDDVLNIIAIDLEQAANLNEEDKKILLERLSKDYPSEIKLKNKKQLKEEGYIKEEGFKDGVLIKIDKVSNEPSGRGFKYSIIRWHGPKGATGYNNSIILYENDKWNIHKGISWEA
>NZ_CP014176.1|WP_039633627.1|3498774_3499095_+|hypothetical-protein
MVPENNNYYRDMQSLRDRCNMYSGFHVIITLTDGSMFDGIIDDVDMDGVTMLVGEDMMEDSPDSDQDQYRQFRPRRRRRMFRRFRRRRFPFASIVALSLLPFPFFF
>NZ_CP014176.1|WP_039633626.1|3499229_3499790_-|nitroreductase-family-protein
MNEILKTIRNRRSTRVFLPEQIKESELNAILEAGIYAPSATNKQPWHFTVIQNKDLIDRLSYSFKEFAKKSDNDYMRKFGENEKFHVFYNSPTVILVSGEIDNRYASIDSAAAVENMLIAGESLGIGSCWIGFIEYLLNSDEGKDFINELKIPEGFRQIHAVSFGYKRNTLTNAPARRENTITYIK
>NZ_CP014176.1|WP_039633624.1|3500675_3501155_-|GyrI-like-domain-containing-protein
MNIQVVKKEEIKVIGLAVNSSYSQISNISILFDQMEERMGEILHKTKESIFIAPFHSRETEFTYYVTVPVEKIENIPNGMIGFVIPSKKYIFATHNGSPSEVENTYLQMFSWMKEHGCEQDYHALSLEIYKNEHSTINSFGDKLQFDIYLPLKKSKNLK
>NZ_CP014176.1|WP_039633622.1|3501761_3502553_+|SDR-family-oxidoreductase-UcpA
MRKLEGKVALITGASKGIGEGIAKVYTKHGAKVVLIARSSSIETLAETLNKEGFEALAIKADVSDMDSINKAVKEATDKFGKIDILVNNAGVCKLGKFLDMSDEDRDFHIDINIKGVWNVTKAVLPLMIKEKYGKIVILSSVTGDIVADPLETAYATTKAALIGFTKSLAREVAEHNITVNAICPGYVNTPMAQSIAVQSNSENPDAVINGIADAVPLKRLAEPEEVGELAAFLGSDESSYITGTQIVIDGGSTLPETVSVGV
>NZ_CP014176.1|WP_039633620.1|3502885_3503794_-|cysteine-synthase-family-protein
MKYLDSVKELIGNTPIIKLNNLDIKPRVNIFAKLENYNPGGSVKDRIGVYMIKQAEKEGRLRPGYTIVEATAGNTGIGVALAAINKGYNIIFVVPEKFSVEKQALMRALGATIINTPRKAGMLGAVEKAEELLKTIENSISLRQFENKSNPFAHYGTTGPEIYEAMDGKIDYFVCGAGSGGTFTGVTKFLKEKNLNIKGILADPQGSTMGGGREGCYDIEGIGNNFIPNTMDMSLVNQVIKVTDEEAYEMVKVLALKEGLIVGSSSGAAVAASLKLANQIDRGNIITVLPDRGDRYFSKNIY

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Crispr_ID: NZ_CP014176_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014176_7

3706040-3706114

Orphan

Consensus_repeat	Method
AGTCAAAGATGCGAAGTATATTTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014176_7

>merge|NZ_CP014176|7|3706040-3706114|CRISPRCasFinder
AGTCAAAGATGCGAAGTATATTTTGAGTTAGGCATCGTAAAAAAATAAATAGTCAAAGATGCGAAGTATATTTTG

>NZ_CP014176|7|6|3706040-3706114|CRISPRCasFinder
AGTCAAAGATGCGAAGTATATTTTG	AGTTAGGCATCGTAAAAAAATAAAT
AGTCAAAGATGCGAAGTATATTTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014176.1\|WP_039630903.1\|3716673_3716997_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|369571
NZ_CP014176.1\|WP_039630930.1\|3698212_3699004_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133382
NZ_CP014176.1\|WP_039630926.1\|3701466_3702069_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369778
NZ_CP014176.1\|WP_039630907.1\|3715886_3716216_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP014176.1\|WP_160289187.1\|3716362_3716626_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_145953082.1\|3693114_3693204_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|294013
NZ_CP014176.1\|WP_039630917.1\|3709818_3711612_-\|oleate-hydratase	unknown	unknown	gnl\|CDD\|237575
NZ_CP014176.1\|WP_039630925.1\|3702181_3703306_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|225019
NZ_CP014176.1\|WP_039630910.1\|3714252_3715017_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133399
NZ_CP014176.1\|WP_039630919.1\|3707566_3709678_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223786
NZ_CP014176.1\|WP_039630921.1\|3706334_3707570_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_039630932.1\|3695071_3696784_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349872
NZ_CP014176.1\|WP_039630915.1\|3711916_3712486_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379534
NZ_CP014176.1\|WP_052267989.1\|3693514_3694966_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP014176.1\|WP_039630923.1\|3704057_3706001_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|214621
NZ_CP014176.1\|WP_039630914.1\|3712728_3713472_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP014176.1\|WP_039630928.1\|3700406_3701249_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368639
NZ_CP014176.1\|WP_039630912.1\|3713458_3714190_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP014176.1\|WP_052267988.1\|3699526_3700174_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014176.1\|WP_052267997.1\|3697054_3698086_-\|agmatine-deiminase-family-protein	unknown	unknown	gnl\|CDD\|377332

Protein	Function_ID	Function_description	E-value
NZ_CP014176.1\|WP_039630903.1\|3716673_3716997_+\|cupin-domain-containing-protein	gnl\|CDD\|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	1.45221e-15
NZ_CP014176.1\|WP_039630930.1\|3698212_3699004_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	1.34994e-22
NZ_CP014176.1\|WP_039630926.1\|3701466_3702069_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.25096e-14
NZ_CP014176.1\|WP_039630907.1\|3715886_3716216_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	6.62613e-44
NZ_CP014176.1\|WP_145953082.1\|3693114_3693204_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|294013	cd00383, trans_reg_C, DNA-binding effector domain of two-component system response regulators. Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.	6.91378e-06
NZ_CP014176.1\|WP_039630917.1\|3709818_3711612_-\|oleate-hydratase	gnl\|CDD\|237575	PRK13977, PRK13977, myosin-cross-reactive antigen; Provisional.	0
NZ_CP014176.1\|WP_039630925.1\|3702181_3703306_-\|radical-SAM-protein	gnl\|CDD\|225019	COG2108, COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only].	3.41197e-106
NZ_CP014176.1\|WP_039630910.1\|3714252_3715017_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133399	cd04772, HTH_TioE_rpt1, First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE. Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.	9.03939e-27
NZ_CP014176.1\|WP_039630919.1\|3707566_3709678_-\|hypothetical-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.36839e-05
NZ_CP014176.1\|WP_039630914.1\|3712728_3713472_-\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.53675e-10
NZ_CP014176.1\|WP_039630932.1\|3695071_3696784_-\|M28-family-peptidase	gnl\|CDD\|349872	cd03875, M28_Fxna_like, M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1. Peptidase family M28; Endoplasmic reticulum metallopeptidase 1 (ERMP1; Felix-ina, FXNA or Fxna peptidase; KIAA1815) subfamily. ERMP1 is a multi-pass membrane protein located in the endoplasmic reticulum membrane. In humans, Fxna may play a crucial role in processing proteins required for the organization of somatic cells and oocytes into discrete follicular structures, although which proteins are hydrolyzed has not yet been determined. Another member of this subfamily is the 24-kDa vacuolar protein (VP24) which is probably involved in the formation of intravacuolar pigmented globules (cyanoplasts) in highly anthocyanin-containing vacuoles; however, the biological function of the C-terminal region which includes the putative transmembrane metallopeptidase domain is unknown.	9.21889e-38
NZ_CP014176.1\|WP_052267989.1\|3693514_3694966_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.57015e-63
NZ_CP014176.1\|WP_039630923.1\|3704057_3706001_-\|VWA-domain-containing-protein	gnl\|CDD\|214621	smart00327, VWA, von Willebrand factor (vWF) type A domain. VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.	3.4647e-10
NZ_CP014176.1\|WP_039630928.1\|3700406_3701249_-\|hypothetical-protein	gnl\|CDD\|368639	pfam05857, TraX, TraX protein. This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits.	2.26177e-17
NZ_CP014176.1\|WP_039630912.1\|3713458_3714190_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.16337e-78
NZ_CP014176.1\|WP_039630915.1\|3711916_3712486_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl\|CDD\|379534	pfam14278, TetR_C_8, Transcriptional regulator C-terminal region. This domain is a tetracycline repressor, domain 2, or C-terminus.	1.31959e-19
NZ_CP014176.1\|WP_052267997.1\|3697054_3698086_-\|agmatine-deiminase-family-protein	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	4.48225e-111

>NZ_CP014176.1|WP_039630923.1|3704057_3706001_-|VWA-domain-containing-protein
MFNFDEQTLIEESKKHCEEFLQKEQRSLATFTGDSSLMYIPDSKLQRFLLNPSKGVLYLPLESFLDRELDDNQIMWHIYYELALYPDWKKQTKKYLNRKKDWQKETDHMTSYIMARIKKEGLENDPAYKPKIISNYVRKEISDLLHLLDKQTSFLRVLQMCPIYRDEENFKKIVSYMKKTGKTIESISQMPRHRAFANSFFIIELYKIEPKIEECVENPFDRKIFNQPFFDFIHYQLIRQINNDQGIIERDPFIRSFIYPIFEQLWKQEIDEMMFYKSKEQKEEQVKGSENPFEQSNSDEMPDSLESTQEEVEKILEEMMDQQDQISESIQNAMQVKVDLEAYGISQSDQQLFEFYSNKMKLEREQMRQFWKKLIGDAKKEVSVKKDGQIKGKLDVDSFISFYPDFVEAEKKGNYKNLPIFNRYLLETRADILPERIEISFVIDNSGSMNPSKIEAARKALAVTLLSIDDFNRYLKSNVEQLNQKVEVLSETWFFGSKYYNVKEFNNKNVSEKEKSDIIRSIVKLNAADGATDDASCLREISNRITPIQESELKKGKQIKIVFEVTDGASSFPGSSKEAVQELLSKNVEVYAFQIGKNSEANEKVFNFVWNEGYKQPHGVMIGEQVEKLPKELLKAVRKNMQSIFNN
>NZ_CP014176.1|WP_039630925.1|3702181_3703306_-|radical-SAM-protein
MKISKSDALIWFDFFAQLPEDEGLSVKHEEIIYATLAQIEAVIDHRNDKLMSEIKGLKTLENRTFFVGNENKFSKGCRSCLLGTGLSAIRKTNKCNLECKFCYNYGQLEDIPPIGEGMWEIGGTKFYEKDIDLLLSIHQKPTGISYVYLEPFMEIEKYYSIVKKFSDAGIHQHLYTNGTLAIEETLKALGEAGLDEIRFNLGASNCSDKVIENIGIAKKYIKNVGIETPMTPELFETFFKKKQAILDTKLDFINCAELHLNENNIDNYSEDNMYISRQGYISPIWSRELTFKFMKIADEENWDLAVHDCSNYTKFARGLNLSSKEGRWFGANDYACEFSRIPYEAFFPILNDDNFQFLSEEELPEGYKPVLIDY
>NZ_CP014176.1|WP_039630926.1|3701466_3702069_-|methyltransferase-domain-containing-protein
MGNTDKFEMIANRYDTSERIQIAKVSSDAIGEYLVGTKSKKAIDFGCGTGLVGMNLLNDFNSMLFLDTSQNMINEVNKKISEFNIKNVETLCFDFEKEGQWDLHTDYIFMVQVLLHINDVELVLSRLYDVLNPGGHLLIVDFNKNEEIVSDIVHNGFDQVKLTDIMAEIGYKDIQSKTFYTGNKIFMGHDASMFILDSQK
>NZ_CP014176.1|WP_039630928.1|3700406_3701249_-|hypothetical-protein
MTLQTSKKGFTGFQIKLLALIFMLFDHIHYFFEFTGKVPVVFSWIGRLAGGLFLFMMIEGYTHTSNRKKYFLKIYSISIAMGVVRFLLETIPQLQRGDGFYAMNGILSTFVILMVMFRGIDYLREKKIFKGILFLIGPFIAPYIIGVFLSPFLTDSLRSYANILFYTVLPAPSIVEGGIYIIISGLILYIFYKNRKVQITAFGLFQFLWMTILPILFIRPISLKLMFTNYYEWMGVFAVIFMFLYNGEKGKPMKKLFYIFYPAHIYILYGLSILLYNLRY
>NZ_CP014176.1|WP_052267988.1|3699526_3700174_+|hypothetical-protein
MDVNEIRPYEKNSLSKKQVGINVILFFVIGIVSGIAAKYMDTVPSNGVIGSIINVMGNIFSQIEVWVLIATIISSWSKTPISAAINVFMFFFGMILSYYIYSMKLFGFFPSYYFIYWGLIAFLSPFAAYVTWYGRGQGWIAALCAALPIGLLLSRGYSFYYLLDISSGFDLAAAILLYFILPINKKQCFKILPWVIVIAFIFRHSSILSHIFGGL
>NZ_CP014176.1|WP_039630930.1|3698212_3699004_-|MerR-family-transcriptional-regulator
MSNKLYNIGEFAAINKITARMLRHYDKVGLLKPAIIRENGYRIYSSKQIATAGLIKKYRDCEFSLKEIEVLLKADEQEVKRFTQGKIQEFYKQESSGQIVLERLRRLSGKESMSFENHYEISFSQQNERILLCLEKLYPEDYIEQAFDKLYDALNYLSVVPSGLPMVLSNLQENNAYRVAVPVKEPLRHTSFQCIVLQAGWYLSTFHYGDYYSIGGAYDRLLLYAQKQKLQLIEPFIERYFVDITNTSDSAEYITEISIKIAP
>NZ_CP014176.1|WP_052267997.1|3697054_3698086_-|agmatine-deiminase-family-protein
MSIYSFPAEGKKHEGTWLSWPHQYTYGREHRDNVEGIWIEMVHALHTGEKVHIIAYNETEKQRITNLLIDERINMTMIDFVIARSDDFWSRDIGPMFVYDENDVLTIINFAFDGWGKKTPYEYDDKIPVAVAKAKGYPIVTVPDFVLEGGAVELDGAGTLMTCKSSVVSKNRNPEMTVEQAEEYLRKYLGATNFIWLEGVTDKDITDAHIDGTARFYDDKTLLTVSKEEFFDLYEDILESDYEKLIFAKNAKGEPYKIVELPLTSKNVEGLEYKGSYLNYYIGNEVILLPVYNDVNDEVAIGILSELYEDREIIPIDVTNLYQHGGMLHCVTQQQPLGKINKV
>NZ_CP014176.1|WP_039630932.1|3695071_3696784_-|M28-family-peptidase
MDAIWNSLKNLFKGKEKNLSKKIPIFLMIIVFVVGTSVGLLQMKPPAVPLESDTDYPAYKRMLDNLKDMTVVPHPSGSKELESVRAHILAQIREMGLESIVETEVYTIEDIKSGLGAEPGEENEIEDHIRNEAHFNKNDELILKNILVKLNAPNTDRGVLMMAHYDTEKGTPGAGDDMISVCALLEAMREQSKNTNLKNDIYFLFCDGEELGAFGSKAFVKSHPELKESIDLVINVDGRGNRGGVLMFESSAYNYDLMRYFKSANSRPLAFSFTSSLYRKMPNTTDMTSFLDAGYSGLNFTVAEGVESYGAMSDNYESFNPRTAYNYLKTVQEMADYSAKEQFQSNSSKQDGVYFPFLPGHLVLMSNTVAYILSGFVVLAALLWLILQIKHGRVRISGIAISMGHQIETMAVMTLLSWCIVTLTTQIMHLSESSNTETLFLCQTLVLTVGTLTIFFFRMRKQSLTEALAGLLPLLLLLIIGTTVFFVSISYLFTLSTLGLLLVAILEKYNIGRLIATTVIGVGILLLYVPVCWLIYVAFMLPITPVVIALSVLPVSIIAAFFATKYVTSR
>NZ_CP014176.1|WP_052267989.1|3693514_3694966_-|serine-hydrolase
MKKYSKVLIIVIGLALMGATLSACGNSNIEANKAEEKNENQTNINKDLMDKYINDAYKRGVFNGTVLLAKGDQIIYENAIGFANQKNKKNLNIDTVFELASVSKQFTASSIMILRDQGKLSLSDKLEKYFPEIPYKGITVKNLLNHTSGLPDYMDWVEQNGRKNNTIPDNEIMEKFIVESKLPVQFEPNEGWDYSNTGYSLLALIVEKSSGLSYEEFLKKEIFEPAGMKDSQVYHRRLNGEKIDNYAYGYVYENGKYILPDDSEGYSEVIPLDGIEGDGAVNSTVHDMLKWSLALKEGKILSHETQEEMYTPTAYNHGKIEYYGYGWSIRNDEKMGRIILHSGGWPGYSTDFVRYIDKDLTFIFLSNIETPNEWGSATFMYGLNSIIRGEEPSPIRDFKELLDKNPSTSQYPSFCGKYEKNVEVFMKENKLFANLPGLDQAVELLPTVDGYFITDVGYSLTFENQRIVIDPKSLYSSVLNKEV
>NZ_CP014176.1|WP_145953082.1|3693114_3693204_-|helix-turn-helix-domain-containing-protein
MTSMEYKLLLYFVENPNRIFTEQQIYETE
>NZ_CP014176.1|WP_039630921.1|3706334_3707570_-|hypothetical-protein
MKINLSVEVKDFKSQVKELREKLNECQRNGILDDGFKEQLNKLLKIEEELLTDLIPYYRVYANDIKKTSMRINPIKQLGAFSFDSFLQTTLRINKKLFITSSMDRKVQFFYIDVVDDFFDHNQIEGEWSPPIKEIKETISFMYKLNDKEILLLGVRGRCYLISSDNFDKLPNVNGEIKVKRVQTNHDLNEFGRCLAIRDGLSVVENGDEKLNLFEIIKENDEYCLLFHKDIYCTIPNWTVLEKINDDYFVVGTKTGELYFIKYENKQFTITEKIDFLNDEIRQIRWLENENGNKNSLIVVGNKGHLKIFPLYEDSKNIKIELNDFKGNLFDAQSKSGTAIVLSEDGIIYLLEENFGNWYLNEDATIKDIFFTNVLKLDVSKYLLMDIEGKLNLLHIDRIDTPKDLWNLPLY
>NZ_CP014176.1|WP_039630919.1|3707566_3709678_-|hypothetical-protein
MKEKTDLKQGYIPTIGEMQSWYEDDLRKEALKSSEYEDNKKIEEQGTFFKAFRRLEERDYEIPHDSKKNNVYYEKYRAYVEEETENKGKKIQEIESSIEYEKFFLRWERRVNSESNNYSHYGSNSATRYRVDCIKKLEKELETILENSPEAWEFYYKRQLISDIETQHQQRLVTVPYVVEAKQKVIDSLNLGVPVYIVGHLGSGKTQLATEAALDFTIQNRIQIELEDKMEDWFSRNPNATESDAIEKFGEFNEERKLHYKNILTDGSKEEIESLQPLFISGSHNLTYEDMFVEKTLSLKHSFSQGSFADYLNMIIGDFYEWMDEHRTRLEKMTDEEQLQLKIQIWKSFSDLLVASNSAFGTEIKKIEREILIAVKEGRPVIVDELNTIAMQNLIALNDILQRHAGNTAYITGVGPVLIKPGFGFIGTGNLSSQMVNYEGTNELNPAFKSRFVTIEYNYVPQKTIGSLEDQEFPERNELFRVIIARLADKDGNIHLPNSKRTLEELFRFSQLCRVTQNVFMGKWKDDEAQKDCGADELELRESVLSIRNILHVLNNWNGGEEKDLSKALWDGFISSITYPDDQNYILSQAVRFGFFPMGEGWKVESKGIGEATTTYDEIRTRPYNYVRPLTETLSYLDVVHLIFGKGTPRKTLPKGLKETFEAAIDDSSRIDAAEYQKLDRQLSHLEHSKDLLEYLEGNGEEK
>NZ_CP014176.1|WP_039630917.1|3709818_3711612_-|oleate-hydratase
MKLKTHDDRLTLTNGSYHALVNARKPKGIEDKKAYLIGTGIAALAAGCFLIRDAHMDGSKITFLEQLDIPGGSLDGQVRQNMGYVARGGREMGHHFEVLWSLFSSLPSTEDPNMTVLDHFYYTNYDDPNFSNCRITKNQGERYDNGKFNLGQDLAKELAAFVNMPDEELEDKAIEDIFSEELLNTDFWTYWRTMFAFENWHSALEMKLYMNRFIHHVDGLPNLSALQFSRHDQYTSFVKPMVKYLEDHGAKFEYGVTVDNVEFSISNDKKVAKKIVATDKTGKDISIDLTENDLVFITNGSMTESSGYGDDNTPAPFNREPEGCWKLWRNIAAQSDEFGNPDKFCTHTEKSNWESCTVTCHDERVPEYIEKITKRSPYGGRTVTGGIVSALDSSWLMSWTINRQEQYYGQPEKDVVVWVYGLFSDVPGDYIKKPMRDCTGKEITKEWLYHIGVPTDEIEELAGSCTAVPVMMPFITSMFMPRAAGDRPYVVPKNGVNFAFLGQFAETLDDPGRDTVFTIEYSGRTAMEAVYVLTGVEKGVPEVFGSRYDIRYLLSAGICLLDGEKPKLDLPPMAKRKVLKQVAGTDVEKLLKEYGII
>NZ_CP014176.1|WP_039630915.1|3711916_3712486_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MAQQYTKKMIREVFIKMLNERPLNKITVKDIATECEINRNTFYYYYTDVYALLSEIFQTELQTVIDEYNDTLSWEESFTVAAKFALENRRAVYHVYNSMQREELVNYIFNVSGNVMIRYVERVSDGISASLEDRKLIASFYQCALTEMVLRWIASGMKEDPDTIIRRIGYLFDGNIELSLKRSAALNDV
>NZ_CP014176.1|WP_039630914.1|3712728_3713472_-|ABC-transporter-permease
MKAFKTMLKTELKLSLRGMDMFIFAICMPVVIIILIGIIYGDKSAFDGAGYTFLEQSFGAITTISVCAGGVMGLPLVISDYRHKKILKRFKVTPINPTVILTVQVVIYALYAIVSLILVYFTAAIFFGFRLNGSWIQFLASYFLVMGSMFSIGLMVGGIAPNLKTASVGASILYFPMLIFSGATLPYEVMPTALQKCSNILPLTQGIKLLKATSLGLAVDNVMMPIIITIALMVICTGIAIRFFKWE
>NZ_CP014176.1|WP_039630912.1|3713458_3714190_-|ABC-transporter-ATP-binding-protein
METVKIHALCKSYGNIQAVNKVSISVKSGEVFGLLGANGAGKSTTIECVLGTKKFDSGSISILGMNPQTQRKELYQRVGVQFQESNYQDKLTVEELCEVTQALYKQPVSYEELLKQFGLSDKCKSQVSELSGGQKQRLFIILALIPNPKVVFLDELTTGLDTRARREVWKGLLDLKKKGLTIFLTSHFMDEIEILCDRICILKKGESIFYGTVQEAIAGSPYEKFEEAYLWYIGEGEEDNESI
>NZ_CP014176.1|WP_039630910.1|3714252_3715017_-|MerR-family-transcriptional-regulator
MKNGYKTAQVAKIIGIHPNTVRLYEKLKLIPKPQRLSNGYRVFSDFHIAQFKLARTALKVEVLQSGLRKNMINIIKLSAQGEFQKAIACTNNYIDQVKIEQKNAEEAIEITKKLLAGIEEKEDDIAFTRKQTAEHLNITIDTLRNWEMNGLFSIKRKENGYRVYTKNDIQLLKIIRSLRLANYSLAAILRMISALSNNSEIDIREVIDTPKADEDIVTVCDELLTSLSNAELNANCVLSKLKSMQEKFNINPTL
>NZ_CP014176.1|WP_039630907.1|3715886_3716216_-|helix-turn-helix-transcriptional-regulator
MPCDKSCPIEYTVNLIGHKWKVLIIRNLLNNGTQRFSELSKGISGISQKMLTQQLKQLESDGIVNRKVYPEVPPRVEYSLTKLGHSLKPVLDSMNTWGVAHIKQNSIKQ
>NZ_CP014176.1|WP_160289187.1|3716362_3716626_+|hypothetical-protein
MLLLHIEINVGTMKNLIKKYTPILFGLLMSSFTSCIISSALGFVGHTSGNFFINWIKEGMTVLCLAVSIATFVPLIIRKGIIKITED
>NZ_CP014176.1|WP_039630903.1|3716673_3716997_+|cupin-domain-containing-protein
MQKINIENILDFAVGKSARKEIFKEGQLDIGLLLYAPGQTTPDHKHSNIDEVFYVISGEGTITINNEPMLVKEKDIIFSPHNETHGFQNTTSSNWVVLQIKMTLPKN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP014176_3	3.18\|2568133\|35\|NZ_CP014176\|CRISPRCasFinder	2568133-2568167	35	NZ_CP014176.1	3082679-3082713	0	1.0

1. spacer 3.18|2568133|35|NZ_CP014176|CRISPRCasFinder matches to position: 3082679-3082713, mismatch: 0, identity: 1.0

ctgcatctgctattagctttactagttctttacac	CRISPR spacer
ctgcatctgctattagctttactagttctttacac	Protospacer
***********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP014176_2	2.21\|2132292\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2132292-2132326	35	MF417875	Uncultured Caudovirales phage clone 10S_11, partial genome	8288-8322	4	0.886
NZ_CP014176_2	2.7\|2131381\|36\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131381-2131416	36	NZ_CP026738	Bacillus megaterium strain YC4-R4 plasmid unnamed2	83633-83668	6	0.833
NZ_CP014176_2	2.7\|2131381\|36\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131381-2131416	36	NZ_CP023318	Bacillus megaterium strain A plasmid p1, complete sequence	91602-91637	6	0.833
NZ_CP014176_2	2.7\|2131381\|36\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131381-2131416	36	NZ_CP049297	Bacillus megaterium strain S188 plasmid pS188, complete sequence	55992-56027	6	0.833
NZ_CP014176_2	2.7\|2131381\|36\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131381-2131416	36	NZ_CP024036	Bacillus aryabhattai strain K13 plasmid unnamed1	120519-120554	6	0.833
NZ_CP014176_4	4.4\|2872731\|32\|NZ_CP014176\|PILER-CR	2872731-2872762	32	MF417875	Uncultured Caudovirales phage clone 10S_11, partial genome	8060-8091	6	0.812
NZ_CP014176_2	2.68\|2133108\|34\|NZ_CP014176\|CRT	2133108-2133141	34	NZ_CP014175	Clostridium argentinense strain 89G plasmid pRSJ17_1, complete sequence	41794-41827	7	0.794
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP028862	Borreliella garinii strain 20047 plasmid lp54, complete sequence	39092-39126	7	0.8
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP018745	Borreliella garinii strain CIP 103362 isolate 20047 plasmid p_lp54_linear	18362-18396	7	0.8
NZ_CP014176_2	2.29\|2132810\|37\|NZ_CP014176\|CRISPRCasFinder,CRT	2132810-2132846	37	MK250029	Prevotella phage Lak-C1, complete genome	75737-75773	8	0.784
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	CM019851	Escherichia coli strain CVM N17EC0326 plasmid pN17EC0326-1, complete sequence, whole genome shotgun sequence	56549-56583	8	0.771
NZ_CP014176_2	2.7\|2131381\|36\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131381-2131416	36	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	264306-264341	9	0.75
NZ_CP014176_2	2.37\|2133367\|37\|NZ_CP014176\|CRISPRCasFinder,CRT	2133367-2133403	37	NZ_LR214953	Mycoplasma neurolyticum strain NCTC10166 plasmid 3	6551-6587	9	0.757
NZ_CP014176_2	2.53\|2134405\|36\|NZ_CP014176\|CRISPRCasFinder,CRT	2134405-2134440	36	NZ_CP037908	Escherichia coli strain LHM10-1 plasmid unnamed4, complete sequence	24749-24784	9	0.75
NZ_CP014176_3	3.16\|2568003\|35\|NZ_CP014176\|CRISPRCasFinder	2568003-2568037	35	KP836356	Marinitoga camini virus 2, complete genome	26684-26718	9	0.743
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NC_024989	Clostridium botulinum plasmid pMI06-01 DNA, complete genome, strain: Miyagi2006-01	4210-4244	9	0.743
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NC_025002	Clostridium botulinum plasmid pTO08 DNA, complete genome, strain: Tochigi2008	4210-4244	9	0.743
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NC_021623	Borrelia hermsii strain HS1 plasmid lp174, complete sequence	84720-84754	9	0.743
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	89430-89464	9	0.743
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP043846	Staphylococcus epidermidis strain ATCC 12228 plasmid unnamed, complete sequence	7029-7061	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP030248	Staphylococcus epidermidis strain CSF41498 plasmid pCSF41498_2, complete sequence	6802-6834	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_HG813244	Staphylococcus epidermidis PM221 plasmid 3, complete sequence	4131-4163	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP023971	Staphylococcus lugdunensis strain FDAARGOS_381 plasmid unnamed1, complete sequence	495-527	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP014117	Staphylococcus epidermidis strain FDAARGOS_153 plasmid unnamed3, complete sequence	4202-4234	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP014120	Staphylococcus epidermidis strain FDAARGOS_153 plasmid unnamed2, complete sequence	326-358	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP009047	Staphylococcus epidermidis strain SEI plasmid unnamed, complete sequence	2873-2905	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP014116	Staphylococcus epidermidis strain FDAARGOS_153 plasmid unnamed4	5606-5638	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	NZ_CP020462	Staphylococcus epidermidis strain 1457 plasmid p1457, complete sequence	1467-1499	9	0.727
NZ_CP014176_4	4.1\|2872665\|33\|NZ_CP014176\|CRISPRCasFinder	2872665-2872697	33	MN693482	Marine virus AFVG_25M316, complete genome	6059-6091	9	0.727
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NC_014937	Bacillus thuringiensis CT43 plasmid pBMB0558, complete sequence	67393-67427	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP004875	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB95, complete sequence	41592-41626	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NC_017202	Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT127, complete sequence	100648-100682	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP011357	Bacillus thuringiensis strain YC-10 plasmid pYC20, complete sequence	55916-55950	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP015155	Bacillus thuringiensis strain Bc601 plasmid pBTBC5, complete sequence	70543-70577	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP004868	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB94, complete sequence	53626-53660	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP010110	Bacillus thuringiensis serovar indiana strain HD521 plasmid pBTHD521-4, complete sequence	19749-19783	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NC_020393	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-107, complete sequence	75756-75790	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP021063	Bacillus thuringiensis strain ATCC 10792 plasmid poh2, complete sequence	36202-36236	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NC_020239	Bacillus thuringiensis serovar kurstaki str. HD73 plasmid pHT77, complete sequence	50388-50422	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP010580	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB76, complete sequence	6501-6535	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP013058	Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-3, complete sequence	33419-33453	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP007614	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB95, complete sequence	40368-40402	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	CP020756	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-17, complete sequence	102034-102068	10	0.714
NZ_CP014176_2	2.13\|2131773\|35\|NZ_CP014176\|PILER-CR,CRISPRCasFinder,CRT	2131773-2131807	35	NZ_CP054716	Salmonella enterica strain 85-0120 plasmid unnamed3, complete sequence	27762-27796	10	0.714
NZ_CP014176_2	2.69\|2133366\|38\|NZ_CP014176\|PILER-CR	2133366-2133403	38	NZ_LR214953	Mycoplasma neurolyticum strain NCTC10166 plasmid 3	6551-6588	10	0.737
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP024391	Borrelia miyamotoi strain Izh-4 plasmid pIzh4-lp72, complete sequence	34602-34636	10	0.714
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP024334	Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-lp72, complete sequence	33449-33483	10	0.714
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP024317	Borrelia miyamotoi strain Yekat-6 plasmid pYkt6-lp72, complete sequence	38914-38948	10	0.714
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP024206	Borrelia miyamotoi strain Izh-5 plasmid pIzh5-lp72, complete sequence	38920-38954	10	0.714
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP024352	Borrelia miyamotoi strain Izh-16 plasmid pIzh16-lp72, complete sequence	38929-38963	10	0.714
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP021873	Borrelia miyamotoi strain CA17-2241 plasmid lp72, complete sequence	40621-40655	10	0.714
NZ_CP014176_3	3.17\|2568068\|35\|NZ_CP014176\|CRISPRCasFinder	2568068-2568102	35	NZ_CP024372	Borrelia miyamotoi strain Izh-14 plasmid pIzh14-lp72, complete sequence	38908-38942	10	0.714

1. spacer 2.21|2132292|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to MF417875 (Uncultured Caudovirales phage clone 10S_11, partial genome) position: , mismatch: 4, identity: 0.886

acaatttggtgtcatgcatatggctataaaaaata	CRISPR spacer
gctatttggtgtcatgcatatggatttaaaaaata	Protospacer
.* ******************** * *********

2. spacer 2.7|2131381|36|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026738 (Bacillus megaterium strain YC4-R4 plasmid unnamed2) position: , mismatch: 6, identity: 0.833

attgaaataacgaaagaagaagcaaaagaaaaacgc-	CRISPR spacer
atgaaaatgacgaaagaagaagcacaag-aaatcgca	Protospacer
** .****.*************** *** *** ***

3. spacer 2.7|2131381|36|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023318 (Bacillus megaterium strain A plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.833

attgaaataacgaaagaagaagcaaaagaaaaacgc-	CRISPR spacer
atgaaaatgacgaaagaagaagcacaag-aaatcgca	Protospacer
** .****.*************** *** *** ***

4. spacer 2.7|2131381|36|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049297 (Bacillus megaterium strain S188 plasmid pS188, complete sequence) position: , mismatch: 6, identity: 0.833

attgaaataacgaaagaagaagcaaaagaaaaacgc-	CRISPR spacer
atgaaaatgacgaaagaagaagcacaag-aaatcgca	Protospacer
** .****.*************** *** *** ***

5. spacer 2.7|2131381|36|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024036 (Bacillus aryabhattai strain K13 plasmid unnamed1) position: , mismatch: 6, identity: 0.833

attgaaataacgaaagaagaagcaaaagaaaaacgc-	CRISPR spacer
atgaaaatgacgaaagaagaagcacaag-aaatcgca	Protospacer
** .****.*************** *** *** ***

6. spacer 4.4|2872731|32|NZ_CP014176|PILER-CR matches to MF417875 (Uncultured Caudovirales phage clone 10S_11, partial genome) position: , mismatch: 6, identity: 0.812

ggcctagcatggcagctaggaaaaataaactt	CRISPR spacer
ggattagcttggcagctaggaaagataagttt	Protospacer
** .**** **************.****..**

7. spacer 2.68|2133108|34|NZ_CP014176|CRT matches to NZ_CP014175 (Clostridium argentinense strain 89G plasmid pRSJ17_1, complete sequence) position: , mismatch: 7, identity: 0.794

ggctttaatactcagaatatgagtctaatttttg	CRISPR spacer
ggttttaatactcagaatatgactctaataaact	Protospacer
**.******************* ******   .

8. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP028862 (Borreliella garinii strain 20047 plasmid lp54, complete sequence) position: , mismatch: 7, identity: 0.8

atttattttaaatataaaaacaatgttta--tagtca	CRISPR spacer
ttgttttttagatataaaaataatgtttatgtagt--	Protospacer
 * * *****.*********.********  ****

9. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP018745 (Borreliella garinii strain CIP 103362 isolate 20047 plasmid p_lp54_linear) position: , mismatch: 7, identity: 0.8

atttattttaaatataaaaacaatgttta--tagtca	CRISPR spacer
ttgttttttagatataaaaataatgtttatgtagt--	Protospacer
 * * *****.*********.********  ****

10. spacer 2.29|2132810|37|NZ_CP014176|CRISPRCasFinder,CRT matches to MK250029 (Prevotella phage Lak-C1, complete genome) position: , mismatch: 8, identity: 0.784

attcaagaaagagtgcaaaattgaaataataattatt	CRISPR spacer
tatctaatgagagtgcaagatttaaataataattatt	Protospacer
  ** *. .*********.*** **************

11. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to CM019851 (Escherichia coli strain CVM N17EC0326 plasmid pN17EC0326-1, complete sequence, whole genome shotgun sequence) position: , mismatch: 8, identity: 0.771

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
agagatattaaatgtaaaaacaatgtttattttta	Protospacer
*   ** ******.****************  *.*

12. spacer 2.7|2131381|36|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 9, identity: 0.75

attgaaataacgaaagaagaagcaaaagaaaaacgc	CRISPR spacer
aacgaaataacgaaagaagcagtaaaagaatctttc	Protospacer
* .**************** **.*******   . *

13. spacer 2.37|2133367|37|NZ_CP014176|CRISPRCasFinder,CRT matches to NZ_LR214953 (Mycoplasma neurolyticum strain NCTC10166 plasmid 3) position: , mismatch: 9, identity: 0.757

atcataaaatgatctcttttaaataaaaaactatctg	CRISPR spacer
actttaaaattatttcttttaaataaaaaacaagtta	Protospacer
*.. ****** **.***************** * .*.

14. spacer 2.53|2134405|36|NZ_CP014176|CRISPRCasFinder,CRT matches to NZ_CP037908 (Escherichia coli strain LHM10-1 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.75

tattatgctaaaaaatattagaagtagaaaaaacat	CRISPR spacer
tattatgctaaaaaatatgaaaagtattttgataat	Protospacer
****************** *.*****    .*  **

15. spacer 3.16|2568003|35|NZ_CP014176|CRISPRCasFinder matches to KP836356 (Marinitoga camini virus 2, complete genome) position: , mismatch: 9, identity: 0.743

aaaatggtagaaggtttaaaagaaaaaatgcaaca	CRISPR spacer
ccatggttagaaggtttaaaagatataatgcaagg	Protospacer
  *  * **************** * ******* .

16. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NC_024989 (Clostridium botulinum plasmid pMI06-01 DNA, complete genome, strain: Miyagi2006-01) position: , mismatch: 9, identity: 0.743

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
gtaacttttaaatataaaaataatgttaataatgt	Protospacer
.*   ***************.****** ***.*

17. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NC_025002 (Clostridium botulinum plasmid pTO08 DNA, complete genome, strain: Tochigi2008) position: , mismatch: 9, identity: 0.743

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
gtaacttttaaatataaaaataatgttaataatgt	Protospacer
.*   ***************.****** ***.*

18. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NC_021623 (Borrelia hermsii strain HS1 plasmid lp174, complete sequence) position: , mismatch: 9, identity: 0.743

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ctgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 * .**** ***********.********* .  *

19. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.743

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ctgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 * .**** ***********.********* .  *

20. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP043846 (Staphylococcus epidermidis strain ATCC 12228 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

21. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP030248 (Staphylococcus epidermidis strain CSF41498 plasmid pCSF41498_2, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

22. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_HG813244 (Staphylococcus epidermidis PM221 plasmid 3, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

23. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP023971 (Staphylococcus lugdunensis strain FDAARGOS_381 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

24. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP014117 (Staphylococcus epidermidis strain FDAARGOS_153 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

25. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP014120 (Staphylococcus epidermidis strain FDAARGOS_153 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

26. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP009047 (Staphylococcus epidermidis strain SEI plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

27. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP014116 (Staphylococcus epidermidis strain FDAARGOS_153 plasmid unnamed4) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

28. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to NZ_CP020462 (Staphylococcus epidermidis strain 1457 plasmid p1457, complete sequence) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
aaacaaattgaaagaacactaaaaagcaagcga	Protospacer
*.**************** ** ***** .

29. spacer 4.1|2872665|33|NZ_CP014176|CRISPRCasFinder matches to MN693482 (Marine virus AFVG_25M316, complete genome) position: , mismatch: 9, identity: 0.727

agacaaattgaaagaacaatacaaagctgtacc	CRISPR spacer
gaagttgttgaatgaacaaaacaaagctgtaca	Protospacer
..*   .***** ****** ************

30. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NC_014937 (Bacillus thuringiensis CT43 plasmid pBMB0558, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

31. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP004875 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB95, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

32. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NC_017202 (Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT127, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

33. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011357 (Bacillus thuringiensis strain YC-10 plasmid pYC20, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

34. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015155 (Bacillus thuringiensis strain Bc601 plasmid pBTBC5, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

35. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP004868 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB94, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

36. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010110 (Bacillus thuringiensis serovar indiana strain HD521 plasmid pBTHD521-4, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

37. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NC_020393 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-107, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

38. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021063 (Bacillus thuringiensis strain ATCC 10792 plasmid poh2, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

39. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NC_020239 (Bacillus thuringiensis serovar kurstaki str. HD73 plasmid pHT77, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

40. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010580 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB76, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

41. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013058 (Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-3, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

42. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007614 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB95, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

43. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to CP020756 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-17, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
gaaaaagatgctaaaacaatagaagaagctataaa	Protospacer
 *  * ..  ********* ********** ****

44. spacer 2.13|2131773|35|NZ_CP014176|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054716 (Salmonella enterica strain 85-0120 plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.714

tatcataggcctaaaacaaaagaagaagctttaaa	CRISPR spacer
aaacgccagccacaaacaaaagaagaagctttagc	Protospacer
 * *.. .***  ********************.

45. spacer 2.69|2133366|38|NZ_CP014176|PILER-CR matches to NZ_LR214953 (Mycoplasma neurolyticum strain NCTC10166 plasmid 3) position: , mismatch: 10, identity: 0.737

tatcataaaatgatctcttttaaataaaaaactatctg	CRISPR spacer
aactttaaaattatttcttttaaataaaaaacaagtta	Protospacer
 *.. ****** **.***************** * .*.

46. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP024391 (Borrelia miyamotoi strain Izh-4 plasmid pIzh4-lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

47. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP024334 (Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

48. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP024317 (Borrelia miyamotoi strain Yekat-6 plasmid pYkt6-lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

49. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP024206 (Borrelia miyamotoi strain Izh-5 plasmid pIzh5-lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

50. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP024352 (Borrelia miyamotoi strain Izh-16 plasmid pIzh16-lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

51. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP021873 (Borrelia miyamotoi strain CA17-2241 plasmid lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

52. spacer 3.17|2568068|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP024372 (Borrelia miyamotoi strain Izh-14 plasmid pIzh14-lp72, complete sequence) position: , mismatch: 10, identity: 0.714

atttattttaaatataaaaacaatgtttatagtca	CRISPR spacer
ccgcatttaaaatataaaaataatgtttatcaaaa	Protospacer
 . .**** ***********.********* .  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1463031 : 1481817

Clostridium_phage(42.11%)

tail,holin,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_052268336.1\|1463031_1463409_-	helix-turn-helix transcriptional regulator	A0A0A7RTK4	Clostridium_phage	2.8e-14	41.3
WP_052268318.1\|1463706_1464255_+	sigma-70 family RNA polymerase sigma factor	S5MNT8	Brevibacillus_phage	5.5e-19	36.7
WP_152609389.1\|1465133_1465646_+	hypothetical protein	NA	NA	NA	NA
WP_039637065.1\|1465648_1466716_+\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A0A7S0D2	Clostridium_phage	3.8e-88	48.4
WP_039637067.1\|1466728_1467151_+\|tail	phage tail tube protein	A0A1V0DZX1	Clostridioides_phage	7.2e-35	50.4
WP_039637069.1\|1467163_1467571_+	hypothetical protein	A0A0A7RTP2	Clostridium_phage	7.3e-16	36.8
WP_163277095.1\|1467582_1467753_+	hypothetical protein	NA	NA	NA	NA
WP_039637071.1\|1467953_1469945_+	hypothetical protein	A0A0K2SUF9	Clostridium_phage	3.1e-27	28.4
WP_052268319.1\|1469955_1470603_+	LysM peptidoglycan-binding domain-containing protein	A0A1V0DZX0	Clostridioides_phage	7.2e-34	39.2
WP_039637072.1\|1470599_1471577_+	hypothetical protein	A0A0A7RWY4	Clostridium_phage	9.2e-57	38.1
WP_039637074.1\|1471578_1471926_+	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_039637076.1\|1471922_1472363_+	DUF2634 domain-containing protein	A0A0A7RUS1	Clostridium_phage	5.4e-25	45.6
WP_039637078.1\|1472355_1473420_+\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	6.9e-74	44.3
WP_039637080.1\|1473409_1473955_+	YmfQ family protein	S6BFJ0	Thermus_phage	5.1e-33	42.9
WP_039637082.1\|1473966_1474746_+	hypothetical protein	A0A2H4J062	uncultured_Caudovirales_phage	9.3e-28	40.2
WP_039637084.1\|1474764_1475082_+	hypothetical protein	A0A2H4J342	uncultured_Caudovirales_phage	1.8e-14	40.7
WP_039637086.1\|1475082_1475298_+	hypothetical protein	A0A2H4J054	uncultured_Caudovirales_phage	7.2e-07	52.1
WP_039637088.1\|1475389_1477213_+	hypothetical protein	A0A2H4J070	uncultured_Caudovirales_phage	1.6e-09	26.5
WP_039637090.1\|1477225_1477564_+	hypothetical protein	NA	NA	NA	NA
WP_163247939.1\|1477553_1477700_+	hypothetical protein	A0A2H4JGH3	uncultured_Caudovirales_phage	3.3e-11	70.2
WP_052268320.1\|1477962_1478394_+\|holin	phage holin family protein	D9ZNF2	Clostridium_phage	8.2e-26	48.1
WP_052268321.1\|1478377_1479145_+	N-acetylmuramoyl-L-alanine amidase	A0A2H4J8A3	uncultured_Caudovirales_phage	2.9e-13	30.8
WP_039637092.1\|1479567_1481817_+	AAA family ATPase	A0A1V0SET7	Hokovirus	2.6e-14	28.1

DBSCAN-SWA_2

1684797 : 1710766

Clostridium_phage(68.0%)

transposase,tail,holin,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039631251.1\|1684797_1685277_-	helix-turn-helix transcriptional regulator	A0A0A7RTK4	Clostridium_phage	1.2e-33	54.7
WP_160289192.1\|1686137_1686293_+	hypothetical protein	NA	NA	NA	NA
WP_163247937.1\|1686708_1687197_+	helix-turn-helix domain-containing protein	I2E8Y5	Clostridium_phage	2.0e-20	37.4
WP_039631255.1\|1688929_1689364_+	HK97 gp10 family phage protein	A0A0A7RTT0	Clostridium_phage	2.2e-42	59.6
WP_052268002.1\|1689350_1689809_+	hypothetical protein	A0A0A7RTI2	Clostridium_phage	3.9e-42	61.7
WP_163247928.1\|1689801_1689975_+	hypothetical protein	A0A0A7RTG1	Clostridium_phage	1.0e-11	70.6
WP_039631257.1\|1689975_1691286_+\|tail	phage tail sheath family protein	A0A0A7S087	Clostridium_phage	9.7e-195	80.2
WP_039631259.1\|1691286_1691751_+\|tail	phage tail tube protein	A0A0A7RVP1	Clostridium_phage	7.4e-65	80.5
WP_039631261.1\|1691766_1692180_+	phage XkdN-like protein	A0A0A7RTN3	Clostridium_phage	6.2e-47	66.4
WP_039631263.1\|1692450_1694616_+	hypothetical protein	A0A0A7S091	Clostridium_phage	1.9e-110	43.4
WP_039631264.1\|1694615_1695278_+	LysM peptidoglycan-binding domain-containing protein	A0A0A7RVP5	Clostridium_phage	2.1e-89	74.4
WP_039631267.1\|1695289_1696264_+	hypothetical protein	A0A0A7RTZ4	Clostridium_phage	8.1e-146	79.6
WP_145953039.1\|1696268_1696601_+	DUF2577 domain-containing protein	A0A0A7RTW1	Clostridium_phage	5.3e-41	78.2
WP_039631268.1\|1696604_1697009_+	DUF2634 domain-containing protein	A0A0A7RTH1	Clostridium_phage	1.0e-49	76.7
WP_039631270.1\|1697009_1698092_+\|plate	baseplate J/gp47 family protein	A0A0A7S096	Clostridium_phage	1.4e-154	73.1
WP_039631272.1\|1698084_1698711_+	DUF2313 domain-containing protein	A0A0A7RVP9	Clostridium_phage	6.9e-82	71.5
WP_163277099.1\|1700280_1700436_+	hypothetical protein	NA	NA	NA	NA
WP_052268005.1\|1700848_1702087_+\|tail	phage tail protein	A0A2H4J039	uncultured_Caudovirales_phage	8.8e-89	77.5
WP_052268006.1\|1702105_1702450_+	hypothetical protein	A0A2H4J342	uncultured_Caudovirales_phage	4.1e-12	44.1
WP_163247926.1\|1702451_1702598_+	hypothetical protein	A0A2H4JGH3	uncultured_Caudovirales_phage	1.1e-09	69.6
WP_039631274.1\|1702694_1704290_+	hypothetical protein	A0A2H4J070	uncultured_Caudovirales_phage	1.3e-113	66.9
WP_039631276.1\|1704302_1704632_+	hypothetical protein	A0A2H4J755	uncultured_Caudovirales_phage	2.3e-44	79.8
WP_080618905.1\|1704624_1704759_+	XkdX family protein	A0A2H4J4R8	uncultured_Caudovirales_phage	3.7e-17	97.7
WP_039631278.1\|1704836_1705256_+\|holin	phage holin family protein	A0A0A7RTU1	Clostridium_phage	5.1e-49	67.6
WP_039631280.1\|1705260_1706004_+	N-acetylmuramoyl-L-alanine amidase	A0A2H4JDW4	uncultured_Caudovirales_phage	4.7e-53	73.0
WP_039631282.1\|1706349_1706553_-	helix-turn-helix transcriptional regulator	A0A0A7RUG5	Clostridium_phage	4.9e-05	50.8
WP_039631284.1\|1706716_1706896_+	hypothetical protein	NA	NA	NA	NA
WP_039631286.1\|1707224_1709021_+	GTPase HflX	NA	NA	NA	NA
WP_186269526.1\|1709575_1710766_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	Q331V1	Clostridium_botulinum_C_phage	3.2e-120	60.5

DBSCAN-SWA_3

2555249 : 2563756

uncultured_Mediterranean_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039630262.1\|2555249_2555819_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	2.2e-18	33.0
WP_039630260.1\|2555811_2556561_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	3.2e-09	28.5
WP_039630258.1\|2557069_2558260_-	D-alanyl-D-alanine carboxypeptidase	A0A1P8VVG5	Erythrobacter_phage	5.3e-06	26.7
WP_039630256.1\|2558583_2559888_-	pyrimidine-nucleoside phosphorylase	A0A0H3UZD4	Geobacillus_virus	1.2e-128	57.7
WP_039630254.1\|2559952_2560771_-	purine-nucleoside phosphorylase	Q5YBA4	Grouper_iridovirus	2.4e-58	43.3
WP_039630252.1\|2560841_2561657_-	purine-nucleoside phosphorylase	Q5YBA4	Grouper_iridovirus	8.2e-59	39.4
WP_039630250.1\|2561668_2562844_-	phosphopentomutase	NA	NA	NA	NA
WP_039630248.1\|2562877_2563756_-	site-specific tyrosine recombinase XerD	A0A1B1IQT7	uncultured_Mediterranean_phage	4.7e-12	22.9

DBSCAN-SWA_4

3014478 : 3086666

Clostridium_phage(59.46%)

holin,tRNA,capsid,tail,portal,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_052268030.1\|3014478_3015198_-\|protease	ATP-dependent Clp protease proteolytic subunit	NA	NA	NA	NA
WP_039631989.1\|3015261_3016449_-	aspartate kinase	NA	NA	NA	NA
WP_039631987.1\|3016463_3016739_-	YlmC/YmxH family sporulation protein	NA	NA	NA	NA
WP_039631986.1\|3016832_3018107_-	insulinase family protein	G3MBJ8	Bacillus_virus	5.0e-47	30.5
WP_039631983.1\|3018807_3020916_-	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_039631981.1\|3021020_3021284_-	30S ribosomal protein S15	NA	NA	NA	NA
WP_039631979.1\|3021716_3022676_-	bifunctional riboflavin kinase/FAD synthetase	NA	NA	NA	NA
WP_039632692.1\|3022687_3023557_-\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_039631977.1\|3023598_3024561_-	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_039631975.1\|3024547_3024913_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_039631972.1\|3024931_3026995_-	translation initiation factor IF-2	E3T4N3	Cafeteria_roenbergensis_virus	6.1e-26	33.1
WP_039631970.1\|3027027_3027327_-	ribosomal L7Ae/L30e/S12e/Gadd45 family protein	NA	NA	NA	NA
WP_039631968.1\|3027316_3027586_-	YlxR family protein	NA	NA	NA	NA
WP_039631967.1\|3027595_3028699_-	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_039631965.1\|3028711_3029173_-	ribosome maturation factor RimP	NA	NA	NA	NA
WP_039631963.1\|3029367_3033696_-	PolC-type DNA polymerase III	X2KQX9	Campylobacter_phage	1.6e-20	34.1
WP_039631961.1\|3033715_3034765_-	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	NA	NA	NA	NA
WP_039631959.1\|3034776_3035814_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_039631957.1\|3035826_3036984_-	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_052268029.1\|3037005_3038004_-	AI-2E family transporter	NA	NA	NA	NA
WP_039631956.1\|3038006_3038804_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_039631955.1\|3038820_3039579_-	isoprenyl transferase	R9W0U9	Flavobacterium_phage	7.9e-32	50.0
WP_039631953.1\|3039799_3040357_-	ribosome recycling factor	NA	NA	NA	NA
WP_039631951.1\|3040371_3041103_-	UMP kinase	NA	NA	NA	NA
WP_039631949.1\|3041200_3042118_-	elongation factor Ts	NA	NA	NA	NA
WP_039631947.1\|3042245_3042947_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_039631944.1\|3043385_3044159_-	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_039631942.1\|3044431_3046534_-	type I DNA topoisomerase	E3T4K4	Cafeteria_roenbergensis_virus	1.4e-110	40.3
WP_039631940.1\|3046616_3047696_-	DNA-protecting protein DprA	NA	NA	NA	NA
WP_145953071.1\|3047715_3048231_-	ATP-binding protein	NA	NA	NA	NA
WP_039631937.1\|3048194_3048665_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_039631935.1\|3048878_3049334_-	hypothetical protein	NA	NA	NA	NA
WP_039632688.1\|3049481_3049673_-	hypothetical protein	A0A2H4J069	uncultured_Caudovirales_phage	3.4e-16	88.5
WP_039631933.1\|3050240_3051371_+	hypothetical protein	NA	NA	NA	NA
WP_039631931.1\|3051437_3052178_-	N-acetylmuramoyl-L-alanine amidase	A0A2H4JDW4	uncultured_Caudovirales_phage	4.7e-53	72.4
WP_039631929.1\|3052182_3052602_-\|holin	phage holin family protein	A0A0A7S099	Clostridium_phage	1.6e-50	71.2
WP_039631927.1\|3052682_3053417_-	discoidin domain-containing protein	NA	NA	NA	NA
WP_039631925.1\|3053435_3054518_-	hypothetical protein	A0A0A7RU66	Clostridium_phage	7.8e-142	69.4
WP_039631923.1\|3054529_3055528_-	hypothetical protein	A0A0A7RW91	Clostridium_phage	8.8e-148	76.2
WP_039631921.1\|3055539_3055794_-	hypothetical protein	A0A0A7S0T0	Clostridium_phage	6.7e-36	85.7
WP_039631919.1\|3055799_3057647_-	hypothetical protein	A0A0A7RU09	Clostridium_phage	1.6e-126	74.1
WP_039631917.1\|3057658_3058900_-	hypothetical protein	A0A0A7RU28	Clostridium_phage	2.7e-207	83.9
WP_039631916.1\|3058901_3059909_-	hypothetical protein	A0A0A7RU61	Clostridium_phage	2.8e-109	61.0
WP_039631914.1\|3059911_3060469_-	hypothetical protein	A0A0A7RW86	Clostridium_phage	9.2e-70	70.1
WP_145953072.1\|3060484_3060820_-	hypothetical protein	A0A0A7S0S4	Clostridium_phage	9.2e-25	77.5
WP_039631910.1\|3060821_3061904_-	hypothetical protein	A0A0A7RU03	Clostridium_phage	4.9e-120	59.4
WP_039631908.1\|3061893_3062295_-	hypothetical protein	NA	NA	NA	NA
WP_039631906.1\|3062307_3064335_-\|tail	phage tail tape measure protein	A0A0A7RU22	Clostridium_phage	2.6e-191	59.2
WP_039631904.1\|3064379_3064589_-	hypothetical protein	A0A0A7RW80	Clostridium_phage	2.1e-19	66.2
WP_052268062.1\|3064581_3064959_-	hypothetical protein	A0A0A7S0S0	Clostridium_phage	1.9e-42	72.6
WP_039631900.1\|3065015_3065897_-	hypothetical protein	A0A0A7RTZ9	Clostridium_phage	1.4e-125	78.0
WP_039631898.1\|3065908_3066307_-	hypothetical protein	A0A0A7RU17	Clostridium_phage	2.2e-33	52.2
WP_039631896.1\|3066306_3066639_-	hypothetical protein	NA	NA	NA	NA
WP_052268028.1\|3066643_3066943_-	hypothetical protein	A0A0A7RW73	Clostridium_phage	2.3e-19	48.5
WP_145953073.1\|3066994_3067297_-	hypothetical protein	NA	NA	NA	NA
WP_039631892.1\|3067235_3067418_-	hypothetical protein	NA	NA	NA	NA
WP_039631890.1\|3067477_3068371_-\|capsid	phage major capsid protein	A0A0H3U2U7	Staphylococcus_phage	4.0e-59	44.2
WP_052268027.1\|3068407_3068950_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_052268026.1\|3069054_3069381_-	hypothetical protein	A0A0A7RU55	Clostridium_phage	2.1e-34	63.6
WP_039631888.1\|3069427_3070312_-\|capsid	minor capsid protein	A0A0A8WJ84	Clostridium_phage	5.1e-14	25.8
WP_039631887.1\|3070292_3071600_-\|portal	phage portal protein	S4UCH0	Listeria_phage	2.4e-36	28.0
WP_039631885.1\|3071612_3073370_-	hypothetical protein	A0A1V0DZW7	Clostridioides_phage	1.6e-115	41.3
WP_052268025.1\|3073854_3074271_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_039631883.1\|3074487_3074910_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_160289203.1\|3074919_3075081_-	hypothetical protein	NA	NA	NA	NA
WP_039631881.1\|3075084_3075510_-	hypothetical protein	NA	NA	NA	NA
WP_039631879.1\|3075931_3078490_-	DNA primase	A0A1S5RH03	Helicobacter_phage	1.4e-08	41.1
WP_186269542.1\|3078521_3079097_-	ERCC4 domain-containing protein	A0A2H4J819	uncultured_Caudovirales_phage	9.2e-33	42.3
WP_039631875.1\|3079113_3079374_-	sporulation transcriptional regulator SpoIIID	M9Q261	Clostridium_phage	2.7e-16	53.3
WP_160289202.1\|3079626_3079779_-	hypothetical protein	NA	NA	NA	NA
WP_039631874.1\|3079793_3079997_-	hypothetical protein	NA	NA	NA	NA
WP_039631872.1\|3080045_3080258_-	hypothetical protein	NA	NA	NA	NA
WP_039631870.1\|3080481_3080952_-	hypothetical protein	NA	NA	NA	NA
WP_039631868.1\|3080993_3081407_-	single-stranded DNA-binding protein	Q8SBL5	Clostridium_phage	3.8e-28	48.9
WP_039631867.1\|3081419_3082025_-	HD domain-containing protein	A0A2H4J8L1	uncultured_Caudovirales_phage	1.6e-38	42.4
WP_039631865.1\|3082037_3082949_-	DUF1351 domain-containing protein	A0A2H4J082	uncultured_Caudovirales_phage	5.8e-13	27.1
WP_039631863.1\|3082949_3083585_-	ERF family protein	A0A0A7RVW0	Clostridium_phage	6.0e-25	37.6
WP_039631861.1\|3083586_3083817_-	hypothetical protein	NA	NA	NA	NA
WP_145953117.1\|3083876_3084023_-	Spo0E family sporulation regulatory protein-aspartic acid phosphatase	NA	NA	NA	NA
WP_039631858.1\|3084117_3084516_-	hypothetical protein	NA	NA	NA	NA
WP_039631856.1\|3084516_3085500_-	hypothetical protein	NA	NA	NA	NA
WP_160289201.1\|3085664_3085817_-	hypothetical protein	NA	NA	NA	NA
WP_039631854.1\|3085819_3086017_-	helix-turn-helix transcriptional regulator	M9Q2L3	Clostridium_phage	6.2e-05	40.4
WP_039631852.1\|3086273_3086666_+	helix-turn-helix transcriptional regulator	A0A2H4J076	uncultured_Caudovirales_phage	7.0e-24	54.3

DBSCAN-SWA_5

3295474 : 3301446

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039633897.1\|3295474_3296980_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	9.1e-64	46.4
WP_039633896.1\|3296985_3297600_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.6e-17	33.0
WP_039633895.1\|3297587_3298586_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	1.5e-67	45.8
WP_039633894.1\|3298780_3300208_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	1.0e-56	32.2
WP_039633893.1\|3300262_3300967_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	7.1e-43	41.7
WP_039633892.1\|3300966_3301446_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	4.0e-29	44.9

DBSCAN-SWA_6

3520211 : 3527281

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039633596.1\|3520211_3520970_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-15	30.0
WP_052268125.1\|3520969_3522031_-	iron ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	1.3e-11	27.4
WP_039633595.1\|3522034_3523171_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_039633594.1\|3523823_3524285_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.1e-42	55.7
WP_039633593.1\|3524352_3525552_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.2e-108	50.8
WP_039633592.1\|3525564_3526209_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.3e-43	47.2
WP_039634165.1\|3526213_3527281_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	3.1e-50	36.2

DBSCAN-SWA_7

4186218 : 4197170

Caulobacter_phage(42.86%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039632899.1\|4186218_4187553_+	phosphoribosyltransferase family protein	A0A172Q0Y1	Acinetobacter_phage	2.1e-19	27.2
WP_039632898.1\|4187567_4188665_+\|protease	cysteine protease StiP family protein	A0A172Q0S8	Acinetobacter_phage	7.6e-44	35.5
WP_052268085.1\|4188661_4189468_+	hypothetical protein	NA	NA	NA	NA
WP_039632897.1\|4189883_4192667_-	calcium-translocating P-type ATPase, PMCA-type	M1I547	Acanthocystis_turfacea_Chlorella_virus	1.8e-89	29.0
WP_039632895.1\|4192708_4193317_-	TerD family protein	K4JRX3	Caulobacter_phage	1.2e-27	34.6
WP_039632893.1\|4193344_4193923_-	TerD family protein	K4JRX3	Caulobacter_phage	3.7e-29	39.5
WP_039632891.1\|4194149_4194728_-	TerD family protein	K4JRX3	Caulobacter_phage	8.1e-29	40.0
WP_039632889.1\|4194953_4197170_-	ribonuclease R	Q0GXV6	Lactococcus_phage	1.1e-78	37.3

Anti-CRISPR protein detection

Acr_ID: NZ_CP014176.1|WP_160289201.1|3085664_3085817_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP014176.1|WP_160289201.1|3085664_3085817_-|hypothetical-protein

3085664_3085817_-

50 aa aa

3014478-3086666

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP014176_3	TypeV	3.18\|2568133\|35\|NZ_CP014176\|CRISPRCasFinder	2568133-2568167	35	3082679-3082713	0

1. spacer 3.18|2568133|35|NZ_CP014176|CRISPRCasFinder matches to NZ_CP014176 position: 3082679-3082713, mismatch: 0

ctgcatctgctattagctttactagttctttacac	CRISPR spacer
ctgcatctgctattagctttactagttctttacac	Protospacer
***********************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP014175

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP014176

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information