CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP020463	Staphylococcus epidermidis strain 1457 chromosome, complete genome	1 crisprs	csa3,WYL,DEDDh,cas3,DinG	0	0	5	0
NZ_CP020462	Staphylococcus epidermidis strain 1457 plasmid p1457, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP020463_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020463_1

2116882-2116972

Orphan

Consensus_repeat	Method
TGTTGAATTTCCCGGTGAAATTCTCTATGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020463_1

>merge|NZ_CP020463|1|2116882-2116972|CRISPRCasFinder
TGTTGAATTTCCCGGTGAAATTCTCTATGTTGGGGCCCCGAACCCCAACTTGCTTTGCCTGTTGAATTTCTCGGTGAAATTCTCTATGTTG

>NZ_CP020463|1|1|2116882-2116972|CRISPRCasFinder
TGTTGAATTTCCCGGTGAAATTCTCTATGTTG	GGGCCCCGAACCCCAACTTGCTTTGCC
TGTTGAATTTCTCGGTGAAATTCTCTATGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020463.1\|WP_001832176.1\|2121446_2122106_-\|membrane-protein	unknown	unknown	gnl\|CDD\|223742
NZ_CP020463.1\|WP_001832181.1\|2123509_2124520_-\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NZ_CP020463.1\|WP_002457534.1\|2124534_2125152_-\|DUF47-domain-containing-protein	unknown	unknown	gnl\|CDD\|224310
NZ_CP020463.1\|WP_001833013.1\|2127552_2128314_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP020463.1\|WP_002455993.1\|2118531_2118891_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NZ_CP020463.1\|WP_002438844.1\|2113697_2114297_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|225188
NZ_CP020463.1\|WP_001832028.1\|2111001_2111490_-\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|225395
NZ_CP020463.1\|WP_011082612.1\|2125673_2127575_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
NZ_CP020463.1\|WP_001832143.1\|2114784_2115930_-\|nitric-oxide-dioxygenase	unknown	unknown	gnl\|CDD\|237337
NZ_CP020463.1\|WP_001832093.1\|2111496_2112705_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341024
NZ_CP020463.1\|WP_001832058.1\|2117086_2117563_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380376
NZ_CP020463.1\|WP_001832120.1\|2117562_2118279_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NZ_CP020463.1\|WP_001832044.1\|2112762_2113617_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP020463.1\|WP_002469187.1\|2122516_2123317_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP020463.1\|WP_001832142.1\|2109395_2109818_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|130141
NZ_CP020463.1\|WP_001832178.1\|2108967_2109264_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020463.1\|WP_002468453.1\|2128459_2129500_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340424
NZ_CP020463.1\|WP_001832064.1\|2114579_2114765_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020463.1\|WP_001832056.1\|2110256_2110946_+\|DUF1129-family-protein	unknown	unknown	gnl\|CDD\|368981
NZ_CP020463.1\|WP_032606369.1\|2116101_2116776_+\|iron-sulfur-cluster-repair-di-iron-protein-ScdA	unknown	unknown	gnl\|CDD\|183940

Protein	Function_ID	Function_description	E-value
NZ_CP020463.1\|WP_001832176.1\|2121446_2122106_-\|membrane-protein	gnl\|CDD\|223742	COG0670, COG0670, Integral membrane protein, interacts with FtsH [General function prediction only].	3.08106e-29
NZ_CP020463.1\|WP_001832181.1\|2123509_2124520_-\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	3.05703e-103
NZ_CP020463.1\|WP_002457534.1\|2124534_2125152_-\|DUF47-domain-containing-protein	gnl\|CDD\|224310	COG1392, COG1392, Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism].	4.24041e-54
NZ_CP020463.1\|WP_001833013.1\|2127552_2128314_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.35373e-102
NZ_CP020463.1\|WP_001832028.1\|2111001_2111490_-\|DUF456-domain-containing-protein	gnl\|CDD\|225395	COG2839, COG2839, Uncharacterized protein conserved in bacteria [Function unknown].	2.3208e-34
NZ_CP020463.1\|WP_001832120.1\|2117562_2118279_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	2.97069e-139
NZ_CP020463.1\|WP_011082612.1\|2125673_2127575_-\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	4.54274e-06
NZ_CP020463.1\|WP_002438844.1\|2113697_2114297_-\|DUF402-domain-containing-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	6.52528e-71
NZ_CP020463.1\|WP_001832143.1\|2114784_2115930_-\|nitric-oxide-dioxygenase	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	2.15135e-120
NZ_CP020463.1\|WP_001832093.1\|2111496_2112705_-\|MFS-transporter	gnl\|CDD\|341024	cd17471, MFS_Set, Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters. This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.79377e-100
NZ_CP020463.1\|WP_001832058.1\|2117086_2117563_-\|cupin-domain-containing-protein	gnl\|CDD\|380376	cd06121, cupin_YML079wp, Saccharomyces cerevisiae YML079wp and related proteins, cupin domain. This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.	5.85126e-71
NZ_CP020463.1\|WP_002455993.1\|2118531_2118891_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.52342e-15
NZ_CP020463.1\|WP_001832044.1\|2112762_2113617_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.11693e-40
NZ_CP020463.1\|WP_002469187.1\|2122516_2123317_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.93935e-38
NZ_CP020463.1\|WP_001832142.1\|2109395_2109818_-\|hypothetical-protein	gnl\|CDD\|130141	TIGR01069, Endonuclease_MutS2, MutS2 family protein. Function of MutS2 is unknown. It should not be considered a DNA mismatch repair protein. It is likely a DNA mismatch binding protein of unknown cellular function. [DNA metabolism, Other].	0.00156082
NZ_CP020463.1\|WP_002468453.1\|2128459_2129500_-\|sensor-histidine-kinase	gnl\|CDD\|340424	cd16948, HATPase_BceS-YxdK-YvcQ-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ. This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.	1.41624e-42
NZ_CP020463.1\|WP_001832056.1\|2110256_2110946_+\|DUF1129-family-protein	gnl\|CDD\|368981	pfam06570, DUF1129, Protein of unknown function (DUF1129). This family consists of several hypothetical bacterial proteins of unknown function.	0.00246668
NZ_CP020463.1\|WP_032606369.1\|2116101_2116776_+\|iron-sulfur-cluster-repair-di-iron-protein-ScdA	gnl\|CDD\|183940	PRK13276, PRK13276, iron-sulfur cluster repair di-iron protein ScdA.	5.38977e-150

>NZ_CP020463.1|WP_032606369.1|2116101_2116776_+|iron-sulfur-cluster-repair-di-iron-protein-ScdA
MITKEDIVANVVTDYPKSADIFRNAGIDFCCGGQESIASAVNHKPNIDLNSLLNKLNHIDNTEGNSTINPKFLNVESLIQYIQSAYHETLKEEFKNLTPYMTKLAKVHGPSHPYLLKLQDLYREFRDSMLDHIRKEDEEDFPKLIQYSQGQDVQNIKIILEDLINDHEDTGQLLNVMNQLTSDYQTPEEACGTWKLVYQRLQNIERQTHQHVHLENHVLFKKVS
>NZ_CP020463.1|WP_001832143.1|2114784_2115930_-|nitric-oxide-dioxygenase
MLTEKEQDIIKQTVPLLQDKGTEITSIFYPKMFEANPELLNMFNQTNQKKGMQSAALAQAVLAAAMNINNLGAIKPAIMPVAHKHCALQVYPEHYPIVGENLLAAIQDVTGLESDDPVIQTWAKAYGEIADVFIKLEQEIYNHMLWKGFKPFKITNITQETSDIKSFTVESEEYDLSQFEPGQYITVDVSSEKLPYRAKRHYSIIDGDENHLVFGVKRDVTTEHEGEVSTILHDEISEGDMINLSAPVGGFSIENTERPQLFIGSGVGMTPLVSMFKKAASLNVPTQMIQAVVTEDERPFAQKLDSITDNYEQAQLHLHVKDKEGYLEAKELEQYLSEQPEIYICGGTKFLHSIINSLKELNYDMNHVHFETFIPRLSVQV
>NZ_CP020463.1|WP_001832064.1|2114579_2114765_-|hypothetical-protein
MKMNPRYVKVFFLYLVSTFISNRLTTNKSLCKTLMQGILGYGLFALGLKYLTIKKKQHQAQ
>NZ_CP020463.1|WP_002438844.1|2113697_2114297_-|DUF402-domain-containing-protein
MTVKVKYIDKRHWRRLVEREYTEVKVNNNRFKGIIGLVTMKKVREPLEVTVVGQNIIVADDNYKWLQILPDKKRYSMTVMFDNKGNPLEYYFDINIKNITQKGNARTIDLCLDVLVLPNGEYELVDEDDLMYALQNKQISKKQYHEAYIIAHQLMIEIEDNFSEIQDKVMRCYHKINHKAQKMKHKRPYKAKKKSHRRH
>NZ_CP020463.1|WP_001832044.1|2112762_2113617_-|LysR-family-transcriptional-regulator
MKIDDYRLLITLDETKTLRKAAEILYISQPAVTQRLKAIEAAFGVEIFIRTKKQLITTTEGSMIIEHARDMLKRERLFFDKIQAHIGEVNGTISIGCSSLIGQTLLPEVLSLYNSQFPNVEIQVQVGSTEQIKAHHRDYHVMITRGNKVMNLSNTHLFNDEHYFIYPKDRKEDVTKLPFIEFQADPIYINQIKQWYNDHLGHDYHATITVDQVATCKEMLLSGVGVTILPKIMMKNIDKNMFEFEKVTIDKKPLIRSTYMSYDASMLQLPQVDAFVNLMLNFIR
>NZ_CP020463.1|WP_001832093.1|2111496_2112705_-|MFS-transporter
MFTALLQIKNYKLFVVNMLLLGMGIAVTVPYLILFATKDLGMTTTQYGLLLALAAISQFIVNSIIARFSDTHHLNRKILIITALFMGAVSFSIYFYVHQIWLFIVLYALFQGLFAPAMPQLYASARESINASSSRDRAKFANTVLRSMFSLGFLFGPFIGAQLIELKGYSGLFGGTIAIILFTLILQVFFYKNLPVKNQISEQQHIEKIAPNMFKDKSLFIPFIAFILLHIGQWMYTMNMPLFVTDYLNEKERYVGYLASLCAGLEVPFMVILGILSAKLPTRTLLIIGSVFGGAFYFSIGVFKNFHMMLVGQICLAIFLAILLGLGISYFQDILPDFPGYASTLFANAMVIGQLGGNLLGGVMSHWVGLENVFFVSASSIFVGMILILFTKDQKITIEDVE
>NZ_CP020463.1|WP_001832028.1|2111001_2111490_-|DUF456-domain-containing-protein
MTAILWILIIIAFALAFIGLIKPVIPSLLMLWIGFLIYQFGFHEGRLSWIFYVAMIIFTIMILVADFVMNKYFVNRFGGSKIGEYTALIGVIVGCFVFPPFGIIIIPFVAVFIVELVQGFNFQQAIKVSFGSVIAFLASTIAQGLIMIVMVIWFFLDVFLIN
>NZ_CP020463.1|WP_001832056.1|2110256_2110946_+|DUF1129-family-protein
MKSTAQLTKENNVKALRLNNTDREIFENYMTYVRADLRVNPHDSELMLNRTLKHLIRAGDTGMLAMEFFNHDPKAHAKKEIRELPNETFKNIFKYISHNFILLIGIFCFLKGLIGFFIGGDSNLLYLYTFPLTVIIGLVIIFLFIWMNFKTVQLQCFNNSYWTWWLTYGVIALLLITLFYVFFIPQSFLAFGPYIKVSNWTFIIIAIIIIPISFYVNHHFYNKEANTRI
>NZ_CP020463.1|WP_001832142.1|2109395_2109818_-|hypothetical-protein
MRKWLTLLLITTLVLTACGKSNEKASLEKSIDQLKKENKDLKKQKKKLQEQKDKLKHKQDSLQEDVNDLPAKSTSRDKKNKDNHDAKEKSSDNQSTSANHDDQTNKIKSNQDEHDSQSSKPHTQQKPSQNDRKNNHRQER
>NZ_CP020463.1|WP_001832178.1|2108967_2109264_-|hypothetical-protein
MHEQDFNILEGKKMTLVELGRELENLTGRTIKDTTSDIKRVIAHLPNFESDTDTFVATYHLNHQNDFIDATFVAPKNQSDRLKEIPVHIKLISYISKN
>NZ_CP020463.1|WP_001832058.1|2117086_2117563_-|cupin-domain-containing-protein
MMTANDWIDRLELISHPEGGYFKETMRGDGKGRASFSSIYFLLTQRDISHFHRIDADEVWYYHAGQTLKIHMITPKGEYHTVKLGRDIDCGECLQYCVPKGTIFASTLDSAEGYSLVGCMCQPGFEYEHFELLTQEYLIRQYPQYESIIKRLAISQED
>NZ_CP020463.1|WP_001832120.1|2117562_2118279_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWNNIKEKKAQKDKNTSRIYAKFGKEIYVAAKSGEPNPESNQTLRLVLERAKTYSVPNHIIDRAIDKAKGAGDENYDHLRYEGFGPNGSMLIVDALTNNVNRTASDVRAAFGKNGGNMGVSGSVAYMFDHTATFGVEGKSVDEVLETLMEQDIDVRDVIDDNGLTIVYAEPDQFAQVQDALREAGVEEFKVAEFEMLPQTDIELSEEDQAIFEKLIDALEDLEDVQNVFHNVDLK
>NZ_CP020463.1|WP_002455993.1|2118531_2118891_-|MarR-family-transcriptional-regulator
MNEQKLIKLLEFYKQYKALSGYIDKKYKLTLNDLAVLYLAKKYCLDERILMQTFLKLATGELDISRTKILMSIRRLIDKEKLNKVRSNRDERKIFLYMDENNMSEFDALFEDVEKFLSY
>NZ_CP020463.1|WP_001832176.1|2121446_2122106_-|membrane-protein
MSQSTHQSTDHKRQSQDKNQTHAYAKVWLYFMYYWMIFGIGCYFGQYLPMSWRKPLSLGLLILILATLFIKRARKYGLVISHIYAIIVGLLSYALFTTYLQNLGAEVFYKNIILAIGAFIAFGIIGYFLIKDASSMGKYLFVTLIALIIAGIIGIFINNPIFHTVITIVSLLLFLLYTLYDFNRMKRGQFSPREMGFNLFINLLNIIEDILSLANRFKN
>NZ_CP020463.1|WP_002469187.1|2122516_2123317_+|LysM-peptidoglycan-binding-domain-containing-protein
MKKLAFAITAASGAAAVLSHHDAEASTQHKVQSGESLWTIAQQYNTSVESIKQNNNLSNNMVFPGQVINVGGSASQNTSSNTSSSSASSHTVVAGESLNIIANKYGVSVDALMQANHLNGYLIMPNQTLTIPNGGSGSGSGGTATQTSGNYTSPSFNHQNLYTEGQCTWYVFDKRSQAGKPISTYWSDAKYWASNAANDGYQVDNTPSVGAIMQSTPGPYGHVAYVERINGDGSILISEMNYANGPYNMNYRTIPASEVSSYAFIH
>NZ_CP020463.1|WP_001832181.1|2123509_2124520_-|inorganic-phosphate-transporter
MSYILIVTIAIVIFSLIFDFINGFHDTANAVATAVSTRALTPRRAILLAAVMNFIGALTFTGVAGTITKDIVDPFKLQHGLVVVLAAIIAAIIWNLITWLYGIPSSSSHALIGSIAGAAIASQGSFAVLHYQGFTKIIIVLIISPIIAFCVGYMMYTIVKIVFKNSNLTRTNRNFRFFQIFTAALQSFSHGTNDAQKSMGIITLALIVGNLQDGSNVEPQVWVKVACATAMGLGTAVGGWKIIKTVGGNIMKIRPANGAAADISSALTIFVASSLHFPLSTTHVVSSSILGVGASNRAKGVKWSTAQRMVVTWVITLPISAVLAAIIYFIIHLFLK
>NZ_CP020463.1|WP_002457534.1|2124534_2125152_-|DUF47-domain-containing-protein
MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELMHQVISDLNQTFITPIEREDILSLCNAIDDVLDAMEETSAMFEMYSIEYTDEYMAEFVENIQKAVAEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSMKHIFNSETDPITLIKIKDIYQSMEEIADKCQAVANNFETIIMKNS
>NZ_CP020463.1|WP_011082612.1|2125673_2127575_-|ABC-transporter-permease
MASIMSFNEIIFKNFKQNVTHYAIYLLSLVISVVLYFSFVTLKYAHHLHGNQSFPAIKEGSQVGSYFLFIIIVVFLLYANFLFLKRRGRELSLLQIIGLTKKDIMKMIMLEQLMTFMMTTIVGIILGIFGSKILLMIVLRLLGINVSVSIIFNYHAILETLLLIAVSYVLIVFQSYVYLLKRSIKELASDVNKKEFSHTRTTLGEVVLGLLGIIMIVSGYIMSTKLVDNVETIIQPFAILFLTVIGSYFFFRSTVSLIFKAIQRLRNGTVSVTDVMFTSPIIYRVKKNAFSLTVMTVVSAITVSVLCFAALSRSTLTNEVLLSSPHDVTLKNQKQANELAFKLNNRNIEHYYNYKEVVYAKVYKDHLFSEGVYRPKEITVTSDKYIPNVSTKKGQTDIIIPRGSLKDVVKTDKKRTAYVGSKKFRLKVSLRKGINKVYFMSDVDRGRPTLILNDEDYQKIREHIKEKNIVSQYGFDLKNKNDLPELEKLVSSINEDIETRSEAASEISSLTGILLFVTSFLGITFLIAAGCIIYIKQIDETEDELENYTILRKLGFTHQDMSKGLKLKVIFNFGLPLIIALLHAYFASLAYMHLMNVTNQIPIFIVMAVYTATYAVFAIIAYNHSKRTIKHSI
>NZ_CP020463.1|WP_001833013.1|2127552_2128314_-|ABC-transporter-ATP-binding-protein
MSILEVRQLSKVYGDKQAFQEVLKEINLDVDEGEFISIMGPSGSGKTTLLNVLSSIDYMTKGSITINGKQLEKLSNKQLSDIRKKDIGFIFQDYNILNTLTVKENIMLPLSVQKLDKQIMHERYQRIVEALNISDISDKYPSELSGGQRQRTSAARAFINLPSIIFADEPTGALDSKSTLDLLKRLKYMNEEFNTTILMVTHDPVAASFSNRVVMLKDGQIFTELYQGDDDKQTFYKEIIRTQSVLGGINYEL
>NZ_CP020463.1|WP_002468453.1|2128459_2129500_-|sensor-histidine-kinase
MNNFRWFWFFIKSRINWILWILFLNIILLGVAYIDYEISVESVFYIVILNVGLSILFLLFTFVKEVRLSKHFYEDKEIEEIKHKDLAETPFQQQVIDYLYRHIAAQKEKVVEQQLQIKNHEQTITEFVHDIKTPVTAMKLLIDQENDDQRKRALLFEWSRINEMLDKQLYLTRLETQHRDMYFDYISLKRMVIDEIQVTRHISQAKGIGFELDFKDEQKVYTDVKWCRMMIRQVLSNSLKYSDNSTINLSGYNIEGHVVLKIKDYGRGISKRDLPRIFDRGFTSTTDRNDTASSGMGLYLVQSVKEQLGIEVKVDSIVGKGTTFYFIFPQQNEIIERMSKVTRLSF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

998722 : 1029331

Staphylococcus_phage(82.14%)

integrase

attL 988851:988867|attR 1029853:1029869

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
988851:988867	attL	NA	NA	NA	NA
WP_002456422.1\|998722_999217_-\|integrase	site-specific integrase	B7T092	Staphylococcus_virus	3.8e-67	76.1
WP_002456423.1\|999375_999588_+	hypothetical protein	A0A2H4JCA1	uncultured_Caudovirales_phage	7.3e-20	72.9
WP_002456424.1\|999967_1000702_-	hypothetical protein	NA	NA	NA	NA
WP_002456425.1\|1000783_1000939_-	hypothetical protein	NA	NA	NA	NA
WP_002456426.1\|1001228_1001516_-	hypothetical protein	A0A2H4JGN1	uncultured_Caudovirales_phage	5.5e-18	50.0
WP_002456427.1\|1001677_1002343_-	hypothetical protein	A0A2H4J5B8	uncultured_Caudovirales_phage	7.0e-08	41.8
WP_002456428.1\|1002437_1002584_-	hypothetical protein	NA	NA	NA	NA
WP_002456429.1\|1003593_1005018_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.6e-173	63.9
WP_001829851.1\|1005007_1006009_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	6.9e-92	50.2
WP_001829824.1\|1006005_1006257_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	1.9e-35	81.9
WP_080280822.1\|1006315_1006792_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	5.6e-44	58.1
WP_002456431.1\|1006778_1007564_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	2.0e-99	71.3
WP_001832979.1\|1007794_1009387_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	2.7e-268	83.2
WP_001829830.1\|1009756_1010956_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.1e-192	85.4
WP_002468818.1\|1011058_1011967_+	hypothetical protein	A0A2H4PQQ8	Staphylococcus_phage	1.8e-102	80.6
WP_002456435.1\|1012146_1012983_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	6.1e-110	68.6
WP_002469577.1\|1013267_1013423_+	hypothetical protein	A0A146ICT8	Staphylococcus_phage	5.2e-15	79.6
WP_001830729.1\|1013749_1014103_-	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	8.5e-05	32.5
WP_001830726.1\|1014099_1014465_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	4.1e-34	57.0
WP_002493962.1\|1014503_1014812_-	hypothetical protein	NA	NA	NA	NA
WP_001830731.1\|1015088_1015802_+	transaldolase	M1PR54	Cyanophage	4.1e-22	37.4
WP_001830728.1\|1015941_1016385_+	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	3.1e-20	42.9
WP_001830734.1\|1016371_1016815_-	competence protein ComK	NA	NA	NA	NA
WP_001830724.1\|1016820_1017300_-	sigma-70 family RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	2.7e-25	42.3
WP_010959195.1\|1017355_1017475_-	hypothetical protein	NA	NA	NA	NA
WP_001830737.1\|1017507_1017723_+	hypothetical protein	NA	NA	NA	NA
WP_001830727.1\|1018100_1018952_+	autolysin	A0A1J0MFB0	Staphylococcus_phage	1.0e-32	35.6
WP_080003818.1\|1019290_1020784_+	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	2.5e-13	65.6
WP_002440254.1\|1021220_1022264_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.4e-134	66.5
WP_001830723.1\|1022270_1022903_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	5.5e-87	77.1
WP_002440250.1\|1022915_1024097_+	GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.8e-176	75.3
WP_001830736.1\|1024109_1024571_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.2e-59	84.2
WP_002468815.1\|1024618_1025620_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	1.5e-131	70.0
WP_032606475.1\|1025862_1026690_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_001830809.1\|1027179_1027581_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_001830894.1\|1027817_1028381_-	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	1.9e-67	66.5
WP_001830802.1\|1028377_1029331_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	3.3e-67	84.7
1029853:1029869	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1754336 : 1762806

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001831672.1\|1754336_1754903_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.0
WP_001831685.1\|1754902_1755934_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.1e-64	43.4
WP_001831721.1\|1755926_1757411_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	9.4e-45	31.9
WP_002470440.1\|1757389_1759579_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.1e-139	40.4
WP_001831727.1\|1759571_1760243_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_001831728.1\|1760244_1760505_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_001831723.1\|1760504_1761209_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	H8ZMN3	Synechococcus_phage	1.6e-47	42.5
WP_032606432.1\|1761209_1762337_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_001831735.1\|1762323_1762806_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	5.2e-21	43.3

DBSCAN-SWA_3

1794045 : 1861504

Staphylococcus_phage(57.63%)

transposase,head,integrase,plate,terminase,holin,capsid,portal,protease,tail

attL 1792482:1792498|attR 1842816:1842832

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1792482:1792498	attL	NA	NA	NA	NA
WP_032606340.1\|1794045_1795509_-	CHAP domain-containing protein	A0A2H4J3K5	uncultured_Caudovirales_phage	2.3e-290	95.9
WP_002502079.1\|1795483_1795894_-\|holin	phage holin	A0A0N9SI57	Staphylococcus_phage	2.9e-57	86.8
WP_032606342.1\|1795957_1796356_-	YxeA family protein	A0A2H4J8T4	uncultured_Caudovirales_phage	5.7e-66	100.0
WP_002502077.1\|1796513_1796921_-	hypothetical protein	A0A2H4J3L4	uncultured_Caudovirales_phage	5.7e-69	99.3
WP_002502076.1\|1796907_1797333_-	hypothetical protein	A0A0N9S016	Staphylococcus_phage	6.7e-73	99.3
WP_032606043.1\|1797329_1797953_-	poly-gamma-glutamate hydrolase family protein	A0A0N9SKG5	Staphylococcus_phage	1.4e-114	98.1
WP_002502074.1\|1797957_1799172_-\|plate	BppU family phage baseplate upper protein	A0A0N9RRU1	Staphylococcus_phage	1.3e-209	100.0
WP_002502073.1\|1799171_1801034_-	DUF2817 domain-containing protein	A0A0N9SJ39	Staphylococcus_phage	0.0e+00	100.0
WP_032606041.1\|1801215_1802784_-	peptidase	A0A0N9SH60	Staphylococcus_phage	6.4e-302	99.8
WP_002502070.1\|1802784_1803618_-\|tail	phage tail family protein	A0A0N7GFH9	Staphylococcus_phage	2.8e-163	100.0
WP_002502068.1\|1808359_1808512_-	hypothetical protein	A0A0N9SKE8	Staphylococcus_phage	1.4e-20	100.0
WP_002502067.1\|1808544_1808907_-	hypothetical protein	A0A0N9SI62	Staphylococcus_phage	3.3e-60	100.0
WP_002502066.1\|1808970_1809156_-	hypothetical protein	A0A0N9STM6	Staphylococcus_phage	3.2e-27	100.0
WP_002502065.1\|1809174_1809801_-\|tail	phage tail protein	A0A0N9S027	Staphylococcus_phage	2.0e-113	100.0
WP_002502064.1\|1809813_1810218_-	hypothetical protein	A0A0N9SKI2	Staphylococcus_phage	9.3e-72	100.0
WP_002502063.1\|1810220_1810487_-	hypothetical protein	A0A0N9RRU6	Staphylococcus_phage	1.2e-43	98.9
WP_002502062.1\|1810621_1810951_-	hypothetical protein	A0A0N7GFI0	Staphylococcus_phage	1.2e-58	100.0
WP_002502061.1\|1810940_1811282_-\|head,tail	phage gp6-like head-tail connector protein	A0A0N9SJ46	Staphylococcus_phage	1.4e-57	100.0
WP_002502060.1\|1811300_1812626_-\|capsid	phage major capsid protein	A0A0N9S8J3	Staphylococcus_phage	1.0e-180	100.0
WP_002497603.1\|1812667_1813225_-\|head,protease	HK97 family phage prohead protease	A0A2H4JBY8	uncultured_Caudovirales_phage	4.1e-102	100.0
WP_002502059.1\|1813214_1814447_-\|portal	phage portal protein	A0A2H4J5A4	uncultured_Caudovirales_phage	2.2e-233	100.0
WP_002502058.1\|1814446_1814641_-	hypothetical protein	A0A2H4JDZ0	uncultured_Caudovirales_phage	6.9e-25	100.0
WP_002502057.1\|1814656_1816408_-\|terminase	terminase large subunit	A0A0N9SI77	Staphylococcus_phage	0.0e+00	100.0
WP_002502056.1\|1816400_1816886_-\|terminase	phage terminase small subunit P27 family	A0A0N9STN1	Staphylococcus_phage	2.3e-85	100.0
WP_002502055.1\|1817045_1817396_-	HNH endonuclease	A0A2H4J3S4	uncultured_Caudovirales_phage	3.4e-62	98.3
WP_002502054.1\|1817878_1818325_-	transcriptional regulator	A0A0N7GFI1	Staphylococcus_phage	2.3e-79	98.0
WP_002502052.1\|1818491_1818674_-	hypothetical protein	H9A105	Staphylococcus_phage	1.1e-24	90.0
WP_002499245.1\|1818778_1819081_+	hypothetical protein	A0A2H4J741	uncultured_Caudovirales_phage	1.0e-46	100.0
WP_002502051.1\|1819177_1819603_-	dUTP diphosphatase	A0A2H4J3S0	uncultured_Caudovirales_phage	3.0e-73	100.0
WP_002502049.1\|1819722_1820130_-	RusA family crossover junction endodeoxyribonuclease	A0A0N9SH85	Staphylococcus_phage	7.1e-72	100.0
WP_002502048.1\|1820139_1820367_-	DUF3269 family protein	A0A0N9RU83	Staphylococcus_phage	3.5e-36	100.0
WP_032606344.1\|1820385_1821351_-	DnaD domain protein	A0A0N7GFI2	Staphylococcus_phage	8.8e-161	99.7
WP_002502046.1\|1821373_1821841_-	single-stranded DNA-binding protein	A0A0N9SKG8	Staphylococcus_phage	3.7e-80	99.4
WP_080033657.1\|1821841_1822459_-	MBL fold metallo-hydrolase	A0A0N9SI86	Staphylococcus_phage	2.9e-85	98.1
WP_032606345.1\|1822539_1823475_-	recombinase RecT	A0A2H4JDY2	uncultured_Caudovirales_phage	8.5e-145	98.5
WP_002502043.1\|1823476_1825426_-	AAA family ATPase	A0A0N9SKM4	Staphylococcus_phage	0.0e+00	99.1
WP_002502042.1\|1825428_1825692_-	hypothetical protein	A0A0N9RRW1	Staphylococcus_phage	1.9e-41	97.7
WP_002502041.1\|1825751_1825943_-	DUF1270 family protein	A0A0N9SJ68	Staphylococcus_phage	2.6e-16	85.7
WP_002502040.1\|1826032_1826314_+	hypothetical protein	A0A2H4JEH2	uncultured_Caudovirales_phage	2.2e-35	67.7
WP_002502038.1\|1826472_1826682_-	hypothetical protein	A0A0N9SHA3	Staphylococcus_phage	4.8e-32	98.6
WP_002499261.1\|1826739_1827078_+	hypothetical protein	A0A2H4JGF0	uncultured_Caudovirales_phage	8.3e-58	100.0
WP_002499263.1\|1827382_1827595_+	hypothetical protein	A0A2H4J5G5	uncultured_Caudovirales_phage	8.9e-34	100.0
WP_002502037.1\|1827728_1828475_-	oxidoreductase	A0A0N9SI89	Staphylococcus_phage	2.4e-134	97.2
WP_002502036.1\|1828525_1829080_+	hypothetical protein	A0A2H4J3U5	uncultured_Caudovirales_phage	5.5e-83	95.1
WP_002499267.1\|1829261_1829501_-	helix-turn-helix transcriptional regulator	A0A1Q1PVY0	Staphylococcus_phage	6.5e-33	91.1
WP_002499268.1\|1829641_1830262_+	helix-turn-helix domain-containing protein	A0A1Q1PVX8	Staphylococcus_phage	4.4e-97	86.4
WP_080280816.1\|1830495_1831635_+	CapA family protein	A0A2H4JG01	uncultured_Caudovirales_phage	1.2e-220	99.2
WP_032606347.1\|1831843_1832428_+	hypothetical protein	A0A1W6JQH1	Staphylococcus_phage	1.4e-28	83.9
WP_032606348.1\|1832496_1833387_+	hypothetical protein	A0EX19	Staphylococcus_virus	9.9e-26	30.7
WP_032606349.1\|1833397_1833577_-	hypothetical protein	NA	NA	NA	NA
WP_032606350.1\|1833671_1834721_+\|integrase	site-specific integrase	A0A2H4J492	uncultured_Caudovirales_phage	1.3e-197	99.7
WP_001829272.1\|1835121_1835697_-	competence protein ComK	NA	NA	NA	NA
WP_011082643.1\|1835723_1835819_-	hypothetical protein	NA	NA	NA	NA
WP_001829292.1\|1835911_1836130_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_001829269.1\|1836207_1837194_-	lipoate--protein ligase	NA	NA	NA	NA
WP_001829339.1\|1837398_1837584_+	DUF2187 domain-containing protein	NA	NA	NA	NA
WP_001829312.1\|1837589_1838192_+	hypothetical protein	NA	NA	NA	NA
WP_002439150.1\|1838294_1839845_-	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_001829321.1\|1839938_1841297_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_001829335.1\|1841314_1843072_-	PDZ domain-containing protein	W5SAB9	Pithovirus	4.6e-06	24.3
1842816:1842832	attR	NA	NA	NA	NA
WP_002439148.1\|1843282_1844089_-	TerC family protein	S5MAL1	Bacillus_phage	3.9e-29	37.7
WP_002446117.1\|1844397_1845960_-	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	1.7e-36	26.9
WP_002439147.1\|1845963_1846209_-	hypothetical protein	NA	NA	NA	NA
WP_001829323.1\|1846198_1847683_-	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_002484726.1\|1848203_1849379_+	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_002494345.1\|1849356_1850550_+	MFS transporter	NA	NA	NA	NA
WP_002468295.1\|1850814_1851324_-	hypothetical protein	NA	NA	NA	NA
WP_001832657.1\|1851477_1852233_-	esterase family protein	NA	NA	NA	NA
WP_002456101.1\|1852458_1853544_+	AI-2E family transporter	NA	NA	NA	NA
WP_001829254.1\|1853942_1854713_-	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_001829249.1\|1854934_1855306_-\|transposase	IS200/IS605 family transposase	NA	NA	NA	NA
WP_002494358.1\|1855379_1855595_-	recombinase	NA	NA	NA	NA
WP_002485412.1\|1856924_1858937_-	ATP-binding cassette domain-containing protein	A0A1B1IVR3	uncultured_Mediterranean_phage	2.0e-106	36.3
WP_080009412.1\|1859281_1860004_-	glucose-6-phosphate dehydrogenase	E3SJC5	Synechococcus_phage	4.3e-27	35.3
WP_077431490.1\|1860013_1860163_-	hypothetical protein	M4SJ15	Cyanophage	3.5e-08	51.0
WP_102962077.1\|1860169_1860673_-	glucose-6-phosphate dehydrogenase	E3SKF6	Synechococcus_phage	2.2e-14	32.7
WP_002467880.1\|1860764_1860968_+	hypothetical protein	A0A0N7GFG6	Staphylococcus_phage	1.5e-09	77.1
WP_107362610.1\|1861034_1861130_-	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_001829295.1\|1861240_1861504_-	DUF4176 domain-containing protein	A0A1X9I6T6	Streptococcus_phage	1.5e-09	41.4

DBSCAN-SWA_4

2042515 : 2052949

uncultured_Caudovirales_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001829596.1\|2042515_2043295_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.1e-18	33.6
WP_002438903.1\|2043291_2044251_-	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	4.1e-17	100.0
WP_002487913.1\|2044234_2045209_-	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.1e-166	100.0
WP_002501752.1\|2045224_2045488_-	hypothetical protein	A0A2H4IYB4	uncultured_Caudovirales_phage	1.2e-16	96.7
WP_001829597.1\|2045462_2046431_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	3.9e-185	100.0
WP_001829582.1\|2046549_2048655_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	100.0
WP_001829589.1\|2048617_2049016_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	2.0e-71	100.0
WP_001829684.1\|2049770_2050646_+	DMT family transporter	NA	NA	NA	NA
WP_001832596.1\|2050659_2051160_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	1.1e-50	70.1
WP_002438897.1\|2051443_2052949_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	5.5e-61	34.0

DBSCAN-SWA_5

2072816 : 2080078

Pandoravirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001830323.1\|2072816_2073968_-	anthranilate synthase component I family protein	A0A0B5J984	Pandoravirus	7.5e-26	39.6
WP_001830349.1\|2073957_2074545_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_001830328.1\|2074841_2075513_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	4.1e-64	55.7
WP_001830341.1\|2075517_2075937_+	6-carboxytetrahydropterin synthase QueD	NA	NA	NA	NA
WP_001830330.1\|2075937_2076651_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	1.6e-55	44.8
WP_001830331.1\|2076752_2077352_+	hypothetical protein	NA	NA	NA	NA
WP_002485887.1\|2077701_2077857_+	hypothetical protein	A0A146ICT8	Staphylococcus_phage	4.4e-14	77.6
WP_010959136.1\|2077948_2078047_-	hypothetical protein	NA	NA	NA	NA
WP_001830329.1\|2078452_2078890_+	hypothetical protein	NA	NA	NA	NA
WP_001830332.1\|2078940_2079414_+	DoxX family protein	NA	NA	NA	NA
WP_001830352.1\|2079388_2080078_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.4e-34	35.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage