CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP020716	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence	1 crisprs	csa3,PD-DExK	1	0
NZ_CP020717	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed2, complete sequence	0 crisprs	csa3	0	0
NZ_CP020715	Cnuibacter physcomitrellae strain XA(T) chromosome, complete genome	8 crisprs	csa3,cas3,WYL,DEDDh	1	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP020716_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020716_1

103241-103381

Orphan

Consensus_repeat	Method
GACGGCACCGCCGATGGTGAGACCGCCGACGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020716_1

>merge|NZ_CP020716|1|103241-103381|CRISPRCasFinder
GACGGCACCGCCGATGGTGAGACCGCCGACGACCAGAACGGGATCGAAGACGGCACCGCCGATGGTGAGACCGCCGACGACCCGACCGGCGTGGACAACGGCGTCGAGGACGGCACCGCCGACGGTGAGACCGCCGACGAC

>NZ_CP020716|1|1|103241-103381|CRISPRCasFinder
GACGGCACCGCCGATGGTGAGACCGCCGACGAC	CAGAACGGGATCGAAGACGGCACCGCCGATGGTGAGACCGCCGACGACCCGACCGGCGTGGACAACGGCGTCGAG
GACGGCACCGCCGACGGTGAGACCGCCGACGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020716.1\|WP_085021845.1\|104299_104929_-\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|182775
NZ_CP020716.1\|WP_085021737.1\|100904_102287_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP020716.1\|WP_157127511.1\|103468_104248_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227049
NZ_CP020716.1\|WP_157127509.1\|93717_94674_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP020716.1\|WP_085021740.1\|109009_110188_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP020716.1\|WP_085021735.1\|97315_99844_-\|DUF2156-domain-containing-protein	unknown	unknown	gnl\|CDD\|378310
NZ_CP020716.1\|WP_085021731.1\|94670_95546_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP020716.1\|WP_174604646.1\|102283_102961_-\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP020716.1\|WP_174604624.1\|108344_109013_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP020716.1\|WP_174604623.1\|106685_107408_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020716.1\|WP_085021741.1\|110597_111497_+\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782
NZ_CP020716.1\|WP_085021846.1\|105106_105853_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227049
NZ_CP020716.1\|WP_085021847.1\|107598_108321_+\|VIT-family-protein	unknown	unknown	gnl\|CDD\|153123
NZ_CP020716.1\|WP_085021734.1\|96565_97315_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377092
NZ_CP020716.1\|WP_085021732.1\|95542_95827_-\|transposase	unknown	unknown	gnl\|CDD\|259851
NZ_CP020716.1\|WP_085021736.1\|99972_100818_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|237134
NZ_CP020716.1\|WP_157127510.1\|95892_96171_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020716.1\|WP_085021742.1\|112058_113273_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224806
NZ_CP020716.1\|WP_085021849.1\|111501_112062_+\|ferric-reductase-like-transmembrane-domain-containing-protein	unknown	unknown	gnl\|CDD\|226582
NZ_CP020716.1\|WP_174604621.1\|93364_93715_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP020716.1\|WP_085021845.1\|104299_104929_-\|VTT-domain-containing-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	1.14752e-50
NZ_CP020716.1\|WP_157127511.1\|103468_104248_-\|hypothetical-protein	gnl\|CDD\|227049	COG4705, COG4705, Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown].	3.29832e-22
NZ_CP020716.1\|WP_157127509.1\|93717_94674_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	4.13733e-79
NZ_CP020716.1\|WP_085021740.1\|109009_110188_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.5378e-29
NZ_CP020716.1\|WP_085021735.1\|97315_99844_-\|DUF2156-domain-containing-protein	gnl\|CDD\|378310	pfam09924, DUF2156, Uncharacterized conserved protein (DUF2156). This domain, found in various hypothetical prokaryotic proteins, has no known function.	3.92423e-76
NZ_CP020716.1\|WP_085021731.1\|94670_95546_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.05487e-66
NZ_CP020716.1\|WP_174604646.1\|102283_102961_-\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.52021e-80
NZ_CP020716.1\|WP_174604624.1\|108344_109013_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.0505e-61
NZ_CP020716.1\|WP_085021741.1\|110597_111497_+\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	6.12295e-46
NZ_CP020716.1\|WP_085021846.1\|105106_105853_+\|hypothetical-protein	gnl\|CDD\|227049	COG4705, COG4705, Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown].	1.81541e-60
NZ_CP020716.1\|WP_085021847.1\|107598_108321_+\|VIT-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	5.63242e-99
NZ_CP020716.1\|WP_085021734.1\|96565_97315_+\|ABC-transporter-permease	gnl\|CDD\|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	9.45974e-38
NZ_CP020716.1\|WP_085021732.1\|95542_95827_-\|transposase	gnl\|CDD\|259851	cd00569, HTH_Hin_like, Helix-turn-helix domain of Hin and related proteins. This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.	0.000416889
NZ_CP020716.1\|WP_085021736.1\|99972_100818_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|237134	PRK12554, PRK12554, undecaprenyl pyrophosphate phosphatase; Reviewed.	2.90621e-125
NZ_CP020716.1\|WP_085021737.1\|100904_102287_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.58977e-45
NZ_CP020716.1\|WP_085021742.1\|112058_113273_+\|hypothetical-protein	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	1.86568e-38
NZ_CP020716.1\|WP_085021849.1\|111501_112062_+\|ferric-reductase-like-transmembrane-domain-containing-protein	gnl\|CDD\|226582	COG4097, COG4097, Predicted ferric reductase [Inorganic ion transport and metabolism].	4.66585e-05
NZ_CP020716.1\|WP_174604621.1\|93364_93715_-\|hypothetical-protein	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	0.000128346

>NZ_CP020716.1|WP_174604646.1|102283_102961_-|response-regulator
MIPVLVVEDDPQMAGLLKRGLTEEGYDVTVAADGVQGLLAATRTPPGIAVLDVMLPGMSGFELCRRLRETQPSIMVLMLTARDDVDDRVRGLDAGADDYLVKPFAFSELAARLRALRRRDSPSTPSVLVVGDITIHTVSHDVSVEGVPVHLSPKEYQLLFLLGTHFEQTVSRTSIMTEIWGTVAHADLNIVDQYVSYLRRKLDVIPAQTRVVTERGVGFRLTASP
>NZ_CP020716.1|WP_085021737.1|100904_102287_-|HAMP-domain-containing-histidine-kinase
MKLVARLSIRARMTIGTLLLATAFFTASAFVVHQIVEQLLRDSTVAVLESDIVPYETSILVEPHDSVDAPGEGQLIAVTDAAGVVVASTLPSDLTNALGPLQHLTPGNSQVSTGSATYAIAVESVQGQDGTWTVVAAQDQNANAVLLSNLTVGLVVGLAVLVLLFTTASWILTGAALRPVERLRRSAVSIVDTGSNDLLPVGKAHDEIAGLASTLNNLIATLRASAARERQMVSDASHELRTPVAVLQTQLELMSNGRGSDLESDLGNARRATARLATLVADLLELSRLDSAIKPGDQATVAQLIDEAGDAIDQGRFRSSHQDITVDLSVDVDVDVGEWVAEIRASTFGRIVTNLVGNSIVALGGKGAIVVTVTAHHAELILTVLDNGPGIDPAFLPHAFDRFSQQDSARVPSDGGAGLGLAIVRAAAGRAGGFAELSNQAGGGLLVTVRLPLRMSSQSA
>NZ_CP020716.1|WP_085021736.1|99972_100818_-|undecaprenyl-diphosphate-phosphatase
MNTLAALLLGLVQGLTEFLPVSSSAHIRVVGELIGTGADPGAAFTAIIQLGTEAAVIVYFWRDIARIVSRWARSLLGRVPRCDPDALLGWYIILGSLPIVVLGVAFQTQIETVFRSLWIVAGTLIVFGILLGIADRVGTKTRTLRDLTWRHAIVYGLAQALALVPGVSRSGGTITGGLLLGYSRAAAARYSFLLAIPAVLGSGLYELVKLVTKPCQDSCVPELFGPVDTALATVVAFLVGLLVIRFFLAFISRYSFLPFVIYRILLGAALIVALSVGVLQP
>NZ_CP020716.1|WP_085021735.1|97315_99844_-|DUF2156-domain-containing-protein
MRIRTGASRTAGRIVATSKLMPVTLLLTGLLVAASVTAFVLDTSGRRGLGQAMSTGFDSVVVQQRWFSTLTTVFFGPNPAALVLFVVAFLVGLGWAERLMGRWRLIIVFLTVTVTGTLVSFLLMAAGVAVRLYAADATRAERVLDPGLAVAGVVMAATAFAPIRTRRRVRIIGFSVLSVFALYAGQPVDVYRLFAGAAGLVFGMLLCRRGPRTHATRSERRTLLAAVVAVTALGPVISMVAPTSHGVLNPLGLLFRNPSRDFAAMAAQCVTGDLSARCVHAIELARLDGPAALLTTVLPLVALLVAARGIQKGRRVSLWAAVSLNLVFAALTVLFYTVTPLWSGEANSFQDQAVDNYAPFIVASVLVPCAIAAMLVAGRRLVDPDARPWPVARLFISVAALFTLCSTLYLGVAAATLSSFTPGTGFADVVANLPERFVPVSFLVYEPVATSATGVAAVVGDWVGPVFWSGVIVLILRSRRLPDPARAAGLERARAAVQRGADSLSWMSLWRGHRYWVGEDGVAIAYRVINDIAITTGSPLGAERDGDASAEFARFCDDRGWTPVFYCVADPYASALRDRGWAVTRIAEESVLHPAEWTVAGKRMQDIRTSINRARRAGIRAEWAGWENLSSVSQRQIAEISELWAAEKTLPEMRFTLGGQEEMTHEGVRLMVALDQDDRVLAVTSWLPRFRDDTVVGWTLDVMRRHPESPNGVMEFLIAETVLRAQSDRIETVSLSAAPLAQSTRNDPGPTDTTSATLGFVAKSLEPFYGFQSLFAFKSKFQPALRELYLCYPEKHQLPTIGMALARAYLPDVTPWQALRFLTTAVRSSRRSRPRRTLAARS
>NZ_CP020716.1|WP_085021734.1|96565_97315_+|ABC-transporter-permease
MVQPEPSLLAAVVCVLILAAVAVTVLAATRVRTPWVAAAAVLRGGVQLAALSLILSGVITSPVWTAVGIAIMFVAAAITSTRRIGWSGVLFARVAAAMAVGVATSVLVVFASGAVPLTPRYALALCGIVIGNAMTITSLTGGILLRSIADRWSEVEGWLALGARPGEATLPLARDAVFRALTPSIDQTKTTGLVVLPGAFVGAIFGGLSPLEAGTFQLIVLAAILASGTLESVILAWGVRRLSARPDVT
>NZ_CP020716.1|WP_157127510.1|95892_96171_+|hypothetical-protein
MTPDPVPLPLELLTSMVTTEGLAFAATAETAATACGFVIVTVAGPLTEDPAPWVPSQSAQAPDPATLPTRRAPATAAVVISPVRRGRSAARW
>NZ_CP020716.1|WP_085021732.1|95542_95827_-|transposase
MPAAKSPEFRRRALDLVAGGEPVAQVARNLGISESGLRRWMAADDVDTGKAEGVTSAEKRELIELRRKNRVLEMEIEILKRASAYFAREHILPK
>NZ_CP020716.1|WP_085021731.1|94670_95546_-|IS3-family-transposase
MMFRLVQELSRDGFPVAVACRVLDVSRSGFYDWKDRPPSQRAARDADLLAVIERAHYDSRGSYGAPRVHAELRLGHGIHVGRKRVARLMRQAGIGGISHRRKRGRVRPLPAPHDDLVRRNFTADAPDRVWFTDITEHSTQTGKVYCAAVLDCFTRRVVGWSIADHMRTELVVDALEMARWQRRPEPGTIVHADRGSQYTSWLFGHRLRQAGLLGSMGRVASSVDNGLMESFWSIMQRELLDRRAWVSQAELGSAIFEWIEGFYNPRRRHSALGYLSPADYEQEHTTAALAA
>NZ_CP020716.1|WP_157127509.1|93717_94674_-|trypsin-like-peptidase-domain-containing-protein
MNITKEASGEPGQAPILSPDGYVVTNTHVVTLDGASGNTSIRVTDVAGRLYDATVVGTDPTADLAVIKLTSATDLTPATFASSADLNVGDLAIAIGAPLGLSGTVTDGIISALNRSITVASSAPANPQDSSPQQTPNWLFDQNGQTQTSRSTIALPVIQTDAAINPGNSGGALLNAQGDLIGINVAIANASKTSSQTGNIGVGFAIPSDLVQRISSEIIATGTASHALLGATVGDATADASATVAGAVIKSVTTQGAATQAGLQAGDVITGLDTIPITSADDLTAQIRAHAPADTVTVHYVRGGQQATTTVTLGTLGG
>NZ_CP020716.1|WP_174604621.1|93364_93715_-|hypothetical-protein
MRTIVHDPDRILPRRLLESWEGARPVADLEDVTATLGDDAVLVVAAPSSRCADVCRQLRKIDDFVPLLAVVDTVDTDIRIGCLLAGADDVLPVDAEPSEWRLRLKALARRRGVPWL
>NZ_CP020716.1|WP_157127511.1|103468_104248_-|hypothetical-protein
MSLPVMMNPHTASPNTPQTVGPKARKIPAVDTLFWAMVVLSAVAGIAAEPAPSPMVRLFLVAGGTLTLIAMVVFQIMLRRYRPVPYWITVVMTSLVGASVANSLGPALAASLGGGLLLLGLIAWLLFERPSSALEVRTVRQESVYWVVVFAALVLGTGMRQLLSVTAHLGSLSSSIVFAAVVALSVIAYSFFRVPASAAFWWAFVGVIPLAGAVAELIAIAAGGAAAAKLTVGLLALVALAVLVVIDSGRNRRRAARGM
>NZ_CP020716.1|WP_085021845.1|104299_104929_-|VTT-domain-containing-protein
MLQSGGFLDPSGLLVGAGPWALAVVAAMIFIETGLLFPFLPGDSLIFTAGLLSTQLGLPLWAVIVTVAIAAVVGDSMGYWIGHRFGRKLFKADARILKLRYLERADEFFVKYGPHALVLARFVPIVRTFIPPVVGASRMHYGRFILWNAIGGVLWAVLLGIAGYFLGQIPIIADNVELIAIGIVVVSVVPIAIAIIRERRRDRRAKDPV
>NZ_CP020716.1|WP_085021846.1|105106_105853_+|hypothetical-protein
MLDKVPQITALFWIAKVLTTGMGETASDFLVTTIDPVIAVVLAFLVLVALLALQLTRTRYIPWLYWATVAMVSVFGTMAADVIHVEFGIPYTVSTAAFAAALAAIFLLWWATERDLSIHSINTSRREIFYWVTVLTTFALGTAVGDWTATVLNLGYFASGLLFLACIAVPTVAYYFFSANRVITFWAAYVLTRPLGASLADWLGVDTSRGGVGLGTGPITLVLLAGIAACVTVMTIRRDTHSVAAAPA
>NZ_CP020716.1|WP_174604623.1|106685_107408_-|hypothetical-protein
MFDTFFGLPLHPFIVHATEVIVPLAAALVLLTALWPRARRWAGYLPAAVTLVALVLVPISKESGESLEGRVGENDLIERHAQLADGLLPWVVGLVLVAGLLLAWTIREKRTALAPADTYGAPVSRRAGPRWVPIVLIVLALIASTGTTVQAVLIGHSGATAVWQEDMSGPPRPATPTRRFVSVLKSSRGSWIDRRDWRRRPRRLHRSYGDRSPERPGAMSKLRGSVSRKTPPIGIPVIGA
>NZ_CP020716.1|WP_085021847.1|107598_108321_+|VIT-family-protein
MQKRLDGSHTDEPHREGLAQRLNWLRAGVLGANDGIVSVAAVVVGVAGATPAVSAIVTAGLAALVGGAISMALGEYVSVSSQRDSERALIAKEKREVADMPEQELEELAGLYRAKGLSEETARRVAEELTAHDALAAHLSAELGIDQEDVVSPWHAALASAVAFTLGAILPMLTIVFLPEGLRIPVTFAVVLVALAVTGYVAAWIGGSSRGRAALRVVVGGLLALLATFAIGTLLGTTVV
>NZ_CP020716.1|WP_174604624.1|108344_109013_+|response-regulator
MSEGARILVVEDDRSLSAMLEELFVDEGYRVTTARDGQQALHLALTEGFDVVVLDRGLPILEGLDVLSRWRRSGVGVPVLVLSALGNPADRVEGLDRGAEDYLTKPFDIDELLARVRALLRRHETTAATLALPGGSHFRPSLRQVIRPSGGSVTLSERESALLEVLARDRNQVFERSTLLRLAFPVAEELGVVDTYVHYLRRKLGRDVIDTVRGIGYRLGGS
>NZ_CP020716.1|WP_085021740.1|109009_110188_+|HAMP-domain-containing-histidine-kinase
MTAEDAALRRTARRLALQFAAVIAMIIALVGIIAYGLVSVSVAEAIDRSLSISGQDLRGDEAPADTWVITVRDGRTESSKTLPAGLPDTTALNEARSAAGPVDTTVSADGHSYAVRTRVDGDILVQVAIDQRESDEELTRLAWSLVGAGAVGVAVAALGGYLLSSRAMRPLTEALARQRRFVADASHELRTPLTLLSTRVQLLRRRINTDASPDRLHAEADAVVADTAALTSILEDLLIAADDRPAAVSAVDVAAIAGEVVTAARAEADAAGIALTLDAPESVHVAAGEAPLRRVLFSLIANALDHARSSVTVIITEEARTVRIRVADDGQGFRDGDRPFERFASNRSPGTGPAHYGLGLALVADVISRYGGSVRVVTELPGGVVEASLPRP
>NZ_CP020716.1|WP_085021741.1|110597_111497_+|FAD:protein-FMN-transferase
MDPTATARWRAWSTDVEVTVTAPALLEDATRLCRAVMDSVDAACSRYRPDSELSRFTRSGSATTPVSRQLADLLSDALAAADMTGGLVDPTLGYRLSQLDGPSLGVSAALARPVRRTDITLENGILTAPPGTAFDLGAIGKASASERAVAAIAAHLGPGVGVLVGIGGDIASTIEHPDGGWQVLVQDKPGDPADQVALTVGAALATSSTQHRRYRVGADLVSHILDPRSLQPVQSPWRTVTCAAVSCVEANAYSTAAVILGHEAVPWLAARYVPARLVDQHYRVTTTEGWPTQIEVAHV
>NZ_CP020716.1|WP_085021849.1|111501_112062_+|ferric-reductase-like-transmembrane-domain-containing-protein
MWAIGRVSGIVSLGLFTASVLLGILTRAGRPLPGLPRFGIVLIHRNVSLLASVFLILHVATLLGDSYAQLSLVDVVVPFLGSYQPFWQGLGTVAFDLVVAVVITALLRHRLPVRVFRLVHWSVYLMWPVAVLHSIGNGTDSTSAWFDILAASAATAVAAATTWRIASTLFRTTPLEKAAQAQRTTR
>NZ_CP020716.1|WP_085021742.1|112058_113273_+|hypothetical-protein
MTLTTPLPSVAPSPAMPARLFAAGPHADATLHAARFGPLPATTGLVATLRDSGLTGRGGGAFPVAAKIDALTGPPATIIGNGSEGEPLSRKDATLLHHAPHLVIDGLLLLAAALNPKARLVIVARPDGVDSVRHALRERADGRDIEVRVAEDRFVSGEATAVVAGLAGAPALPKDHPLHLTQRGVGRRPTLLFNVETLAHVALIGRYGAGWFRSLGTPEDPGTRLLSINGDGIGEHVLEVPGGTRIIDALTAVGANPDAVQAVLVGGFHGRWVPARHLTRSLTPRPAPDADGAPVGAGVILAIGVETCGLTVTGSILEYLAAESAGQCGPCVLGLPRLATRYAEHASGQEVDASRVWQLIETLPGRGACHHPDGTAALARSALTVFTAELDRHRAGTCCEGPHR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP020716_1	1.1\|103274\|75\|NZ_CP020716\|CRISPRCasFinder	103274-103348	75	NZ_CP020716	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence	103274-103348	15	0.8

1. spacer 1.1|103274|75|NZ_CP020716|CRISPRCasFinder matches to NZ_CP020716 (Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence) position: , mismatch: 15, identity: 0.8

cagaacgggatcgaagacggcaccgccgatggtgagaccgccgacgacccgaccggcgtg	CRISPR spacer
cagaacgggatcgaagacggcaccgccgatggtgagaccgccgacgacccgaccggcgtg	Protospacer
************************************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP020715_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_1

248079-248181

Orphan

Consensus_repeat	Method
GTTTATGAGCAGTGGATGCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_1

>merge|NZ_CP020715|1|248079-248181|CRISPRCasFinder
GTTTATGAGCAGTGGATGCGCGCAGGCCGGTGGAAGCGTCGAGTGCTCAGAATCAGCGCTACCTCTGCATGGATCGCGTGTTTATTGAGCAGTGGATGCGCGC

>NZ_CP020715|1|1|248079-248181|CRISPRCasFinder
GTTTATGAGCAGTGGATGCGCGC	AGGCCGGTGGAAGCGTCGAGTGCTCAGAATCAGCGCTACCTCTGCATGGATCGCGTG
TTTATTGAGCAGTGGATGCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085021252.1\|244999_246085_+\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380577
NZ_CP020715.1\|WP_115364871.1\|239369_239543_-\|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|171510
NZ_CP020715.1\|WP_085017811.1\|246171_247110_+\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239117
NZ_CP020715.1\|WP_174604363.1\|250298_251933_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP020715.1\|WP_085017812.1\|247140_247992_+\|pyridoxal-kinase-PdxY	unknown	unknown	gnl\|CDD\|235592
NZ_CP020715.1\|WP_085021253.1\|252022_252760_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP020715.1\|WP_085021254.1\|252864_253524_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|224001
NZ_CP020715.1\|WP_085017817.1\|258198_259533_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NZ_CP020715.1\|WP_085021251.1\|238911_239328_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP020715.1\|WP_085021256.1\|259579_260536_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP020715.1\|WP_085021255.1\|257028_258060_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP020715.1\|WP_085017810.1\|244210_244894_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319914
NZ_CP020715.1\|WP_085017813.1\|248382_249861_-\|DUF222-domain-containing-protein	unknown	unknown	gnl\|CDD\|367155
NZ_CP020715.1\|WP_174604362.1\|237428_238838_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP020715.1\|WP_085017816.1\|255172_257032_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|225789
NZ_CP020715.1\|WP_085017815.1\|253550_255089_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP020715.1\|WP_085017808.1\|240260_242171_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|236223
NZ_CP020715.1\|WP_085017809.1\|242687_244214_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238623
NZ_CP020715.1\|WP_162818367.1\|249928_250135_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367471
NZ_CP020715.1\|WP_085017807.1\|239648_240086_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085021252.1\|244999_246085_+\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380577	cd06354, PBP1_PrnA-like, periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type 1 periplasmic sugar-binding protein-like fold.	6.01892e-70
NZ_CP020715.1\|WP_115364871.1\|239369_239543_-\|PLDc-N-terminal-domain-containing-protein	gnl\|CDD\|171510	PRK12452, PRK12452, cardiolipin synthase.	0.00149195
NZ_CP020715.1\|WP_085017811.1\|246171_247110_+\|nucleoside-hydrolase	gnl\|CDD\|239117	cd02651, nuc_hydro_IU_UC_XIUA, nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains proteins similar to nucleoside hydrolases which hydrolyze both pyrimidine and purine ribonucleosides: the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the inosine-uridine-xanthosine preferring nucleoside hydrolase RihC from Escherichia coli and the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium. This group also contains proteins similar to the pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases URH1 from Saccharomyces cerevisiae, E. coli RihA and E. coli RihB. E. coli RihA is equally efficient with uridine and cytidine, E. coli RihB prefers cytidine over uridine. S. cerevisiae URH1 prefers uridine over cytidine. .	1.6123e-115
NZ_CP020715.1\|WP_174604363.1\|250298_251933_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.39547e-90
NZ_CP020715.1\|WP_085017812.1\|247140_247992_+\|pyridoxal-kinase-PdxY	gnl\|CDD\|235592	PRK05756, PRK05756, pyridoxal kinase PdxY.	2.12039e-162
NZ_CP020715.1\|WP_085021253.1\|252022_252760_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.60567e-19
NZ_CP020715.1\|WP_085021254.1\|252864_253524_+\|alpha/beta-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	0.00086435
NZ_CP020715.1\|WP_085021251.1\|238911_239328_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.07472e-09
NZ_CP020715.1\|WP_085021256.1\|259579_260536_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.12252e-102
NZ_CP020715.1\|WP_085021255.1\|257028_258060_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.97195e-86
NZ_CP020715.1\|WP_085017810.1\|244210_244894_+\|VOC-family-protein	gnl\|CDD\|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	7.25888e-12
NZ_CP020715.1\|WP_085017813.1\|248382_249861_-\|DUF222-domain-containing-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.75005e-17
NZ_CP020715.1\|WP_174604362.1\|237428_238838_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	7.26976e-23
NZ_CP020715.1\|WP_085017816.1\|255172_257032_-\|glycoside-hydrolase	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	2.03649e-35
NZ_CP020715.1\|WP_085017815.1\|253550_255089_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.60198e-66
NZ_CP020715.1\|WP_085017808.1\|240260_242171_+\|FAD-dependent-monooxygenase	gnl\|CDD\|236223	PRK08294, PRK08294, phenol 2-monooxygenase; Provisional.	0
NZ_CP020715.1\|WP_085017809.1\|242687_244214_+\|amidohydrolase-family-protein	gnl\|CDD\|238623	cd01298, ATZ_TRZ_like, TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are catalyzed by atrazine chlorohydrolase (AtzA), hydroxyatrazine ethylaminohydrolase (AtzB), and N-isopropylammelide N-isopropylaminohydrolase (AtzC). All three enzymes belong to the superfamily of metal dependent hydrolases. AtzA and AtzB, beside other related enzymes are represented in this CD.	9.47921e-99
NZ_CP020715.1\|WP_162818367.1\|249928_250135_-\|hypothetical-protein	gnl\|CDD\|367471	pfam03381, CDC50, LEM3 (ligand-effect modulator 3) family / CDC50 family. Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w, and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.	0.00964723
NZ_CP020715.1\|WP_085017817.1\|258198_259533_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.50382e-101

>NZ_CP020715.1|WP_085017812.1|247140_247992_+|pyridoxal-kinase-PdxY
MKILSIQSAVAYGHVGNSAAVFPLQRIGVEVLPVYTVNFSNHTGYGAWRGPLISPDDVRDVITGIEERGVFPQIDVVLSGYQGGTGIGDVIVDAVKRVKAANPSAIYACDPVMGNAKSGCFVAPEIPDLLRDRVVPVADIITPNQFELGYLTGTEPASLESTLESVDLARAMGPSTVLVTSVERPDREPETIEMLAVDDEGAWIVQTPLIPIKANGSGDVTAALFTAHYRSTGSAQVALERTASSVYDLIDATYRSGERELQLVETQDAYAHPQLQFAARRVR
>NZ_CP020715.1|WP_085017811.1|246171_247110_+|nucleoside-hydrolase
MRDLILITDPGQEQAVAIWTILASPEDFRVLGVIASAGNTTLDNTVANVHRVLELAGADDIPVFKGVSRPLVRPLVTAAHVHGESGLDGYVFPPVRGAAQEESGVQALIRICRAAPPASVTIAQFSSMTTLAVALTEAPDIAVHIREVVMMAGAYFEVGNITPAAEFNVYVDPHAASIVLESGLPLVMLPLDVTHQLRNTRARLDAFSALGNEVGRAVDALLTFSETFDLEKYGWDGAPLHGPVVPMYLLRPELFRGRRINARVETGSELTMGMLVADWWHVTDLPRNVWYAREVDAEPFYQELLARIGRLS
>NZ_CP020715.1|WP_085021252.1|244999_246085_+|BMP-family-ABC-transporter-substrate-binding-protein
MTHRTTPRLLLSAGALLTAAVALAGCASAPAGSGGSTSAGASSDFLPCIVSDEGGFDDQSFNQLGLQGVTDAAEALGTKHIDVQSSSETDYAPNISNLVDQGCTAIVTMGYALAAATQEAADANPDVDFIMVDDNTVSGDNIKSVMWDTSQAGFLVGYAAADYTTSGKVGTYGGAQIPPVTLYMDGFARGVEYHNQVKGTNVQVVGWNPDSQEGLFTGNFSDINAAKVLSQGILDQGVDVIVPVGGPIYQGAAQAIRESSKPIALVGVDTDMYLSDPEYDDLWFTSIARDMPKSISEVIQKAASGEFSNEEYVGVLSNGGVLMSPFHDFESKVAPTLQGELDDIQAQIIDGTITIETPSAP
>NZ_CP020715.1|WP_085017810.1|244210_244894_+|VOC-family-protein
MRLDDICLVNSDVTASDDFYRLELGFERRMRNVRFVDFVFTTGPRIAMWMRPSITETVGSVYPTSPGLPFRVTVGDGGGVDRVAIDPDGFATVLTPGVPRVTALELAVSDVGRTAAFLSTLGFAPAPGHGADAFDGGGLPIVLTPLADVPRDDRAAPDGWTRNGGHVMLAIELDTGDAVDRAYAELVARGLQLSGEPAVYEWGARSTYAVDPDGFIWEIYAWVEEPR
>NZ_CP020715.1|WP_085017809.1|242687_244214_+|amidohydrolase-family-protein
MPTLWRDALVLTLDGSPDGVRPRRSDLLIDGSEVVDLGSGLDAPEGADVRDGRDLLILPGLVNAHTHSWEILFRGTSERLPLELWTLVSYPPLGVEPLPDRLVYLRTAIAALESLRGGATAVLDDVGELPTQSPESIEQVFAAYDDLGIRAVCTGAVADIAMVDRLPGADHRFSPALLAESRSALHPSAALIDAYLELSMSAIAAAGSRSSGRIAYAVSPSAPHRCSDDLLRACHDLALDRDLLVHTHLLETRLQADVAHERWGRTAVEHLSDLGLLDDRLIAAHGVWLTASDRRMLGAAGSTIAHNPLSNLKLGSGVLDWRGMREAGVRLALGTDGASSSDTLRMLETVKAAALGQSTTESDLESWPTAAEVLAAATRSGAAALRTGAGVIAPGRPADLLVIDLARDTAFTPRHDVVRQLVFSADASSMAEVWVAGECVVRDGRSTCVDDVALLREFRQEAERWAETVPAIRSANARLVEPAAAAYRSAREADRPAEAHPSTERGIR
>NZ_CP020715.1|WP_085017808.1|240260_242171_+|FAD-dependent-monooxygenase
MQFHHHGYVSGDPRIQEAAGTGIDRPEELPDEMDVLIVGTGPAGMITAAQLSQFPDITTRIVERRPGRLAIGQADGIQARSVETFQAFGFAEQIIQEAYRITEMCFWKPDPADPSRIIRTARPVDDELGVSEFPHLIVNQARVLDYFGDVMRTSPTRMTPDYGWEFVSLEVDDAAQHPVAVTLARTAGPDEGALRVVRAKYVVGCDGARSRVREQIGCTLAGDQANHAWGVMDALAVTDFPDIRTKCAIQSEAGSILLIPREGGYLFRMYVDLGEVAADDHGAVRRTSLDQIIAQANAILHPYTLDVKDVAWHSVYEVGHRVTDRFDDVLPDDLGSRTPRVFITGDACHTHSAKAGQGMNVSMQDGFNLGWKLAHVLEGRSPAELLSTYSAERQVVAQNLIDFDKEWSALMAAKPEDLPSPSELEDFYVRTAEFPAGFMTEYTPSLITADSSHQALATGFPVGKRFRSAPVTRVCDGNPVHLGHHARADGRWRIYVFADAAAPAAGEPGPVPALAEWLTTSSSSPLAATPADADPDAWFDVKVIYQQPHSEVDLGAAVPAAFLPRVGPFELVDYEKVYAAAPADDIFDARGVSRDGAIVVVRPDQYVSAVLPLTATDELATFFAPLLAARPVSAGV
>NZ_CP020715.1|WP_085017807.1|239648_240086_-|hypothetical-protein
MIIWTRWGIFAFLFVGLGVGLGFLLKAAVGLGRVTEPSVSGIFVGLGFLVSGVALFFFDKYVVRAHLDKPRQLTYTRQLAQPYTHPDGRIQTHEVVPAVDPQSGQPLVVAPRSSLFFIPLRFWPYIIAGLGLVILIINFVVFLAR
>NZ_CP020715.1|WP_115364871.1|239369_239543_-|PLDc-N-terminal-domain-containing-protein
MLAATVLWILAIVSIARTPGFTTTERVIWILVVLILPLLGSIGWFVFGRRSGTSSAR
>NZ_CP020715.1|WP_085021251.1|238911_239328_-|GNAT-family-N-acetyltransferase
MVEVQNAIHAAGLRAHPVDEDFVRERYLAVEHTVACSVAEEDGRILGFQSLKRSWPDNPYGVPEGWGIIGTLIRPDAGRRGLGRRLFAVSRSAAEAAGLHHIDASIGADNAGALAYYAAMGFVPSGRRGDVIPHRLDL
>NZ_CP020715.1|WP_174604362.1|237428_238838_-|LCP-family-protein
METSVSRRRAAGALLAGTLVPGTGHVLVGARSTGIPLTALSGTLLLAVALLVARLASSPLDAIAFGAAADGLGVVGLASALWLVYVAAVAADLLRRLRMRSAASARRRLSLAAVALLVIPAVICSTISASAFTGRGILTSVFGGDTGLEAHDGRYNILVVGADRAPGRSVVQPDSITVVSVDALTGRTAVVGVDRTTQNFPYPAGSVMASQFPSGNRCLSGCNINFTYQYGLEHADLWAGSPDPGLSALTEAVEGYTGLTMSGHVYVELDAFIRLIDALGGVTVDVKAEVPRIGVPDIGSDQLSVVGPPIEPGVQHMDGETALWFARSRYASSNSDRMQRQSCIQQALLKQLDPGTALSVFLSLAGTTEGLSTDLSPEALGTLAALADGARSQPLDRVELTKPLVQPLQPDLDVVASALRSALHPGEDGEESTSPTAPPAPLSGGLSAPVSPGAGGDDAPSAEPLCSVP
>NZ_CP020715.1|WP_085017813.1|248382_249861_-|DUF222-domain-containing-protein
MTEETRTTTRTPRFEPARASDPAVVAVEERQRVLLSRLEEGRRAEAALHAERLRLLAEFAETADELAALLHPDRVTEARDMQRRSMTAEVAVALNVSERFVTAETCDAETITALPTTLNALARGDISRQHVHKLVTHLNTLPAETWEAFEAAVLPLAVQLNPARFDNLARRMRERLHPDSLTIRARQAREERSAWISEDRDGMAHLHLYAGAEDILAIDSRLHHHARALAAEPDETRMIPQLRADTAVDLLLGTSAATGGAAVELVVTVPATTLAGVAEEPGELSGYGPVDPDTARRLAAAAPAFTRVLTRPDTGEIVSVGRASYRLPAALRRRLRVEDERCRFPGCNRRAITADADHTTAWQDGGSTTRDNLAHLCRRHHRVKHATDWDVTQDPDRTLTWTSPLGRTTTTRPPQRDLADAALRARAILTRAQDSDRPTTPDRENPPPPISDNSLPRTSNPDPDNGPALTARGRGVLARIRTPRPLPERTPF
>NZ_CP020715.1|WP_162818367.1|249928_250135_-|hypothetical-protein
MRSLTPGRPRLSLILGIVFIVVGVLCIPLAISQAHHEYGIHFWWLVIAPLAGGLYFAIAGAIALSRQR
>NZ_CP020715.1|WP_174604363.1|250298_251933_+|EAL-domain-containing-protein
MTHIVHAPDDPLFELLVDAITDYSIYLLSPTGIIQSWNNGAKRIKGYEAAEIVGTSFRRFFTPEDRDADEPGRILRAVETSGRVETEGWRVRKDGTRFWANVIVSQVRRPTGELLGYAKITRDVTQQREIREALDRTVRTDALTGIANRTQFFESFGELIASATGRVAVAVIGLDRLKLVNDEHGHPIGDLLLRTRAADLVQALDDPRSVAARLGGDQFVCAIPFDTATELSAVLDRVGAAFSTPLPVGQDYVSTTASVGVAVHPDDATDVDHLLIDADLAMSRAKRTLTAGPQFFTAELDDAMRSRRYMAHELSSALARGQMRLVYQNQVRVSDGVVVGREALLRWDHPRLGSVSPGVFIPLAEATNDIIVIGDWVLTEACTQAAVWTDGLRVAVNVSPAQVARDTWVDELRRALEVSGLPPERLEIEVTESALLNQTPDTLRHLMDAQALGVSIALDDLGAGYSSLGTLLSFPFDKIKIDRALIARYPEDVRAPSALRAMLTLGHTLPAQVLVEGVETLDQLRLIEQQGFDEAQGYHLHRPQ
>NZ_CP020715.1|WP_085021253.1|252022_252760_+|alpha/beta-hydrolase
MVFGVVGAGAEIGAVPPEIVLIHGIGVSHRYFERLHRRLGREARVVAIDLPGFGGLPKPHWNPTIGEMAAALAEVLDRLEVGHAVLVGQSMGSQWVTELAVQRPDLASHVVLIGPVSDERHRTPLSQGVALLADILREPPRSNLIVLTDYLRCGPRWFGAQLRWMLSYRLEDAVERLTVPLLVLRGARDPIAGMRWCRGLRDRAPEAGLVLVPRAPHNAQTTAPVAVASALLAFVAAHPAVRDAA
>NZ_CP020715.1|WP_085021254.1|252864_253524_+|alpha/beta-hydrolase
MLRIPGWWIADYAYAAHWQVRAFFSRLDPIELTTGHLRPVVVLPGVYETWRFLQPLAQALHDRGHPVHVVEALGSNRRPVAEAAAEVADYLEEHDLEDVVLAAHSKGGLVGKYAMTLGGSARRIRSMVAVASPFAGSLYARWLPLPTLSIFSPRDPTILALARERSVDERIVSVFGAFDPHIPEGSRLPGAKNVELDTGGHFRVLADPRVIGELVALSE
>NZ_CP020715.1|WP_085017815.1|253550_255089_-|MFS-transporter
MTTTGTRRGTRVLALVAMTFANAMVLVDQTAVPLILPSVMDDLHVGSQMVQWVLTGSLLPLAGLLVFGGRLGDLFGHRRIFVLGTVIFAGASACAGFAPTFEVLIAFRVLQGAGGALMLPTTVAVISSVYPGAERGRALGIMGGIAAIAGALGPAIGGGLTTSLGWRSVLLINVPLAALAVIAAFVSVKADARRTVRPHVDLRGTLLLCVALVGLVFGLSQSQSWGWASPGVLIPLVVAVAAGVVFVIWERRTPDPLLDFALLRKYPNYAGATLSQGFAGVAEMGLGVLFPLLLVLNLGMDPGLAGLALIPSTLPMILIAPLAGRWYDRSGGRLPLTVGFLVLALAGIALAIGVHSRDYWMLFPGFLVYGIGLALVLTVNDPVSLDTVPEKDHGQASGVSATAEQFGGAFGIAVLYLVFHTVYVLRLDSGLAGALTPAQQEQLKDDIIAAESTGLHPSTFDPAFSRYLELTLDSSIWGMSVAFLTVTVLALVALVLTRRFVRPGPPPADPDA
>NZ_CP020715.1|WP_085017816.1|255172_257032_-|glycoside-hydrolase
MTAPTFPRGRAALPDATTQDGTYPRPQLVRARWTDLSGPWDFAWDDSLERTPSEVEFHHRIEVPFPPESPASGLGDTGFHPCVWYRRTITPADLEGAGFAVGDDARLLLHFGAVDHDCEVWLNGALVATHSGGQTPFSADVTAHLTGEGDELVVRAVDLPSDVSILRGKQDWRQEPHTIWYHRTTGIWQPVWLEAVPATSIAHVAWRSDLVSATVDAEIELRGRVDPGAELTVALRHAGELLAQSSVRTLGESIVTVRLVIPRQLNGQAYEELLWSPDRPTLLSATVSITGDGASADEVASYVGLRSVGTAPDALLLNDRPVPFRAVLAQNYWPETHNAATAEMLRREVELILELGFTAARVHQKAEDPRFLFWADRLGLMIWGETASAYAFDRRSMTELVTEWSAIVRRDSSHPSIVTWVPLNESWGVQHISHDPRQQAFSRSIADLTRALDGTRPVISNDGWEHTRSDIVTIHDYECDPSVLAERYGSRESLQRMLDGFGPAGRRMTAGVDDPRRPAHDDSLPVMLTEFGGVSLATGTEGDWGYATAADPDGFESHVTDILGVVGRMRTLAGYCYTQLTDTGQETNGLLYADRTPKFPIERIRAAVQGRTAPVSPEA
>NZ_CP020715.1|WP_085021255.1|257028_258060_-|LacI-family-DNA-binding-transcriptional-regulator
MARPTLKDVADRVGVSAKTVSNVVNGTGWVTAELRERVQAALVEVGYRPNSAARQLRSGRTGMLAVALPDLSQPYFAELAAELVREAQARSITVLVNQTDGRADIERRISEGIGSPAVDGLIMSPLALGARDLEGRRDTTPLVLLGEHIGESVLPHVTVDNSAAARAATERLLSLGCRRIVAIGAQSEGPNETSVLRLSGYREALTAAGLEVDESLILPVDGYHRADGAHAARTLLEAGTDFDAVFAFNDLLALGALHVLVTSGIRVPDDVAVIGFDDIEEARYSTPALSSVSPDTTALVRTALDLLAPDPAGTDSAPAPSARGMHTIGFTVVDRASTRGPAE
>NZ_CP020715.1|WP_085017817.1|258198_259533_+|ABC-transporter-substrate-binding-protein
MKTQHPRSGRARRPFRALTAVAGIAIAGLALAGCTGQGSGGGGASETDASGKVTLDFWNGFTGPDGPALQKVIDDFNASQDTVEVTANIMPWDTLYQKVLTSVASSDGPDIIAMSASRMPQFASQGLFMGVDDYYTDESHDSKALNQAAIDASVFDGVNYGVPVNYTPMMLYYNKDLFTAAGLDPEKPPTTWDEFAAMVPKLTVDQDGDGKPDQYAIAMGDHETVPIYPSLLWGTGGGIVSDDGKTSTLADPESLKALDFWVSLVRDQKATQIGMSGADADKLFQTGKAAMEIVGPWMTSGFDEAGLNYGLAKPPAGPTDPAVLADVVSMGLPANTSDEKKAAAYQFFAYWNSAEGQTTWADGSGFPPNRSDVADKVTSSPYPAIFGAQDVADDAKLLLPGIAQGGPILETVFTPALQRALNGEGSVQDIFTAASADVQSQLGK
>NZ_CP020715.1|WP_085021256.1|259579_260536_+|sugar-ABC-transporter-permease
MTTTVGPPTERTTAPRPAPPRRRRPLLKANGRRALTAWLFLTPSLIVLLAFTLYPMIQAGYLSLTDYNLIRAARFVGLDNYVELFQDPAFWNAFGNTVLYAVVVTPVTVVLALLFALMLNQRFVGRSFARTAIFLPFIVSLGIIAIAWAFLLDPNIGLLSYWLGEIGIVPEQGWLNDPRYAMAAVMAVGVWKNVGFYMVIYLAGLQSIPGEIYEASRLDGAGPWQRFRSVTLPLLSNQTLLVSVLALIATLQAFDQIWVMTHGGPFFRTETLVMLVYREGFQQLRFGYASAISFVLLVFVFILSMVQFGYLRRKQVTY

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Crispr_ID: NZ_CP020715_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_2

830538-830633

Orphan

Consensus_repeat	Method
ACTCGGAAAGCGCTCTTTCCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_2

>merge|NZ_CP020715|2|830538-830633|CRISPRCasFinder
ACTCGGAAAGCGCTCTTTCCGGGTGCACTCGCCCGTCCTAACCCGAGCACACCCAGAACGCGCGGGTGCCGGACTCGGGAAAGCGCTCTTTCCGGG

>NZ_CP020715|2|2|830538-830633|CRISPRCasFinder
ACTCGGAAAGCGCTCTTTCCGGG	TGCACTCGCCCGTCCTAACCCGAGCACACCCAGAACGCGCGGGTGCCGGA
CTCGGGAAAGCGCTCTTTCCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085018580.1\|837735_839793_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|130728
NZ_CP020715.1\|WP_085018576.1\|835792_836908_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380528
NZ_CP020715.1\|WP_085021328.1\|840059_841127_+\|VIT1/CCC1-transporter-family-protein	unknown	unknown	gnl\|CDD\|153124
NZ_CP020715.1\|WP_085018565.1\|829336_830446_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085018571.1\|833025_834075_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NZ_CP020715.1\|WP_085018563.1\|828597_829182_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP020715.1\|WP_085018569.1\|831493_832897_-\|Nramp-family-divalent-metal-transporter	unknown	unknown	gnl\|CDD\|234815
NZ_CP020715.1\|WP_085018573.1\|834071_835796_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP020715.1\|WP_085018559.1\|825899_826682_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP020715.1\|WP_085021327.1\|823809_824364_+\|methylthioribulose-1-phosphate-dehydratase	unknown	unknown	gnl\|CDD\|274521
NZ_CP020715.1\|WP_085018554.1\|819776_820517_-\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|378480
NZ_CP020715.1\|WP_085018561.1\|826829_828593_-\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_CP020715.1\|WP_085018552.1\|819039_819711_-\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|378480
NZ_CP020715.1\|WP_085018578.1\|837078_837654_+\|cupin	unknown	unknown	gnl\|CDD\|380360
NZ_CP020715.1\|WP_174604394.1\|841727_842936_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173852
NZ_CP020715.1\|WP_157127084.1\|841312_841642_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085018555.1\|822820_823726_+\|acireductone-synthase	unknown	unknown	gnl\|CDD\|319768
NZ_CP020715.1\|WP_085018567.1\|830830_831340_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085021326.1\|820660_821725_+\|methylthioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235578
NZ_CP020715.1\|WP_085018557.1\|824484_825870_-\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085018580.1\|837735_839793_-\|FUSC-family-protein	gnl\|CDD\|130728	TIGR01667, Uncharacterized_protein_HI_1680, integral membrane protein, YccS/YhfK family. This model represents two clades of putative transmembrane proteins including the E. coli YccS and YhfK proteins. The YccS hypothetical equivalog (TIGR01666) is found in beta and gamma proteobacteria, while the smaller YhfK group is only found in E. coli, Salmonella and Yersinia. TMHMM on the 19 hits to this model shows a consensus of 11 transmembrane helices separated into two clusters, an N-terminal cluster of 6 and a central cluster of 5. This would indicate two non-membrane domains one on each side of the membrane.	1.45684e-28
NZ_CP020715.1\|WP_174604394.1\|841727_842936_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173852	cd01163, DszC, Dibenzothiophene (DBT) desulfurization enzyme C. DszC is a flavin reductase dependent enzyme, which catalyzes the first two steps of DBT desulfurization in mesophilic bacteria. DszC converts DBT to DBT-sulfoxide, which is then converted to DBT-sulfone. Bacteria with this enzyme are candidates for the removal of organic sulfur compounds from fossil fuels, which pollute the environment. An equivalent enzyme tdsC, is found in thermophilic bacteria. This alignment also contains a closely related uncharacterized subgroup.	1.18969e-102
NZ_CP020715.1\|WP_085018573.1\|834071_835796_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	1.39018e-165
NZ_CP020715.1\|WP_085018571.1\|833025_834075_-\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	1.392e-67
NZ_CP020715.1\|WP_085018563.1\|828597_829182_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.44992e-21
NZ_CP020715.1\|WP_085018569.1\|831493_832897_-\|Nramp-family-divalent-metal-transporter	gnl\|CDD\|234815	PRK00701, PRK00701, divalent metal cation transporter MntH.	4.95438e-145
NZ_CP020715.1\|WP_085021328.1\|840059_841127_+\|VIT1/CCC1-transporter-family-protein	gnl\|CDD\|153124	cd02433, Nodulin-21_like_2, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_2: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	3.78766e-80
NZ_CP020715.1\|WP_085018559.1\|825899_826682_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.03366e-34
NZ_CP020715.1\|WP_085021327.1\|823809_824364_+\|methylthioribulose-1-phosphate-dehydratase	gnl\|CDD\|274521	TIGR03328, dehydratase-enolase-phosphatase_complex_1, methylthioribulose-1-phosphate dehydratase. Members of this family are the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine. [Amino acid biosynthesis, Aspartate family].	6.00339e-47
NZ_CP020715.1\|WP_085018554.1\|819776_820517_-\|DUF2510-domain-containing-protein	gnl\|CDD\|378480	pfam10708, DUF2510, Protein of unknown function (DUF2510). This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	4.76632e-05
NZ_CP020715.1\|WP_085018561.1\|826829_828593_-\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	7.32004e-113
NZ_CP020715.1\|WP_085018552.1\|819039_819711_-\|DUF2510-domain-containing-protein	gnl\|CDD\|378480	pfam10708, DUF2510, Protein of unknown function (DUF2510). This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	1.07625e-07
NZ_CP020715.1\|WP_085018578.1\|837078_837654_+\|cupin	gnl\|CDD\|380360	cd02232, cupin_ARD, acireductone dioxygenase (ARD), cupin domain. Acireductone dioxygenase (ARD; also known as 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase) catalyzes the oxidation of 1,2-dihydroxy-3-keto-5-methylthiopentene to yield two different products depending on which active site metal is present (Fe2+ or Ni2+) as part of the methionine salvage pathway. The ARD apo-enzyme, obtained after the metal is removed, is catalytically inactive. The Fe(II)-ARD reaction yields an alpha-keto acid and formic acid, while Ni(II)-ARD instead catalyzes a shunt out of the methionine salvage pathway, yielding methylthiocarboxylic acid, formic acid, and CO. ARD belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.35024e-45
NZ_CP020715.1\|WP_085018555.1\|822820_823726_+\|acireductone-synthase	gnl\|CDD\|319768	cd01629, HAD_EP, Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep. Enolase-phosphatase E1 (also called MASA) is a bifunctional enolase- phosphatase which promotes the conversion of 2,3-diketo-5-methylthio-1-phosphopentane to 1,2-dihydroxy-3-keto-5-methylthiopentene anion (an aci-reductone) in the methionine salvage pathway. The catalytic reaction is carried out continuously by enolization and dephosphorylation, and the enolase activity cannot be classified as typical enzymatic enolization. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.31882e-88
NZ_CP020715.1\|WP_085018576.1\|835792_836908_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380528	cd06305, PBP1_methylthioribose_binding-like, similar to methylthioribose-binding protein of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. Proteins similar to methylthioribose-binding protein of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. The sugar-binding domain of the periplasmic proteins in this group is also homologous to the ligand-binding domain of eukaryotic receptors such as metabotropic glutamate receptor (mGluR), DNA-binding transcriptional repressors such as LacI and GalR.	3.59962e-74
NZ_CP020715.1\|WP_085021326.1\|820660_821725_+\|methylthioribose-1-phosphate-isomerase	gnl\|CDD\|235578	PRK05720, mtnA, methylthioribose-1-phosphate isomerase; Reviewed.	6.48622e-81
NZ_CP020715.1\|WP_085018557.1\|824484_825870_-\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	1.0295e-151

>NZ_CP020715.1|WP_085018565.1|829336_830446_+|hypothetical-protein
MSAQGTQGWDRTTTGRAPSSGFGRAFLWLLAIPAGAGVGVLFWIILLARSRDVPLWLAALIGAGLGVVVAGTSIANRWQRHVRQQAIAARHPGAVVVDAVRVREDAGVFSQVIRTQASAGYAVAFDDAGMHVYDGGSDAQSILDVAWPYVLGFTEESLAINDQARRPGLAVRFATSTVPVVLPFAVAGAPGFPAGTRGIAALRSVLEEMRARYGGSPAGSSAAATPSAPWGQSAAYATPTRRRIVARPSSAIWTLVSRILGGLAALAVVVTVVFNVGSFSLRWRWVGGRMLDQLLWVSVVLVAAAIVALIVRRVVAGMETRAGYTVSRLGPASLDQVDPRTGYVLRPAGTPQLSEQQQRAALARIRSLA
>NZ_CP020715.1|WP_085018563.1|828597_829182_-|PadR-family-transcriptional-regulator
MSRSFTSNGFSGSGFGGSRGGGIEGIWEAMEEFRSRFEKKVGTRVGRGDVRAAVLTLLSERPMHGYQIIQEIEERSGGSWKPSAGSVYPTLQLLADEGLVSADESNGRKTYALTEAGLVVAASSASGSPFATAAESDSDSDGGRRGRGALPKAGFELAQIAAQVGRTGTPEQVEQAVAELEGARRRLYAILAQD
>NZ_CP020715.1|WP_085018561.1|826829_828593_-|AarF/ABC1/UbiB-kinase-family-protein
MTAPAPAGAAPRPDRGDSVPDARISRARYRRILRFAGWNLAVTWFFELLLPRIGLTRVAERTRAKRMQRFARRFHVLAVDLGGLMIKVGQFMSSRLDVLPPEITKELEGLQDEVAPVPFDAIRALAEAELGMPLPAAFAYVDPVPVAAASLGQAHRARLVPRDAAETGLDAVVLKVQRPGIDTIVEVDLAALRRVGRWLSHVRLVYSRVDAPALVEEFAQTSLEEIDYLHEAANSVRFAEEFAGDPRVGVPEVVWERSTRKVLTLQDVTAIKITDAAGLAAAGIDPAEVAPVFAAVMFDQLFTNGFFHADPHPGNVFVTPMPPGSTDAAVQASGEPVPAWRLTFIDFGMMGTVPPNTRSGLRKMLIAAASRDGKGLVAAAQDLGVLLATADTRELERALTQLFARFGGMGFAELREVDPREFREFGLEFGHVVRSLPFQLPENFLLIIRAMSLTSGVCSALNPAFNLWESVEPYAQQLIREERGNVASDIGRQALDNLALAWRLPARLDALVTRVEEGSLAVTNPALERRIARLERTMTRAVSALLFGALLVAGAVVRTEDAVFGTVLMVVSLLPLLHSLFGGRRGG
>NZ_CP020715.1|WP_085018559.1|825899_826682_-|FadR-family-transcriptional-regulator
MSDHAEARAWQTVLDRIEGDLLTGALSPGDHLPSERTLAADLGVGRSSVREALRVLEVMGLIRTQTGSGPQSGAIIIARPSGAMSALLRLQVAAQGFAVEDIVATRLVLESAVAAQLATRIRAAAVSGSAAGAAPAPDLVEVHELLAAMDEPDIADAPAEFLPLDQAFHLALAAASGNQVIAATMAGLRASIEAYVLEGASHLPDWTTTSRRLRAEHRAVVESITAGDPASAERRMRDHIETYHSETSRARAAHTASAGG
>NZ_CP020715.1|WP_085018557.1|824484_825870_-|alpha-hydroxy-acid-oxidizing-protein
MVQRRIPKVRDLAPLMQFKKPQLNAKKRRLDSALTVYDLQRIARRRTPKAAFDYTEGAAEAELSLARARQAFEDIQFTPSILRDVSTVTTGWDVLGAPVSLPFGIAPTGFTRMMQTEGEIAGAGAAGAAGIPFSLSTMGTTAIEDVKAANPNGRNWFQLYMWKDRDRSMALVERAAKAGFDTLLVTVDVPVAGARLRDKRNGFSIPPQLSVGTVVNAIPRPEWWINFLTTEPLSFASLDRWSGTVGELLDSMFDPTVTFEDLEWIRDQWPGKVVVKGVQSMDDARRLAEVGVDGITLSNHGGRQLDRAPIPFHLLPDVAREYGKDMEIHLDTGIMSGADIVASVALGARFTLVGRAYLYGLMAGGREGVDRMIAILGEQITRTMRLLGVNALEELNPGHVTQLERLIPRAVAPAAAQAAEAAPAARKAARSAAPSAPKPAAKAPAKPVSKDEAATPATLDA
>NZ_CP020715.1|WP_085021327.1|823809_824364_+|methylthioribulose-1-phosphate-dehydratase
MPGTAGNLSVTLGRDPLRLAVTASGLDKGELTASDIVIVDDAGEGVVGEGGSEQRPSAEAGLHARIAAVTGAGAAIHVHALAAVRAGHQWPGGVVLHDLEMLKGLGHRAHGERVVIPVVPNGQDMRVLGDAFERQYVRPTASVAEVPALIVADHGIYAWGADLRQARWHLELTEALLQIALSRA
>NZ_CP020715.1|WP_085018555.1|822820_823726_+|acireductone-synthase
MRRRRTSSPAGALPRPSRSVPSTPLPRCPCRRLRRPAALSATAPHPPDHRPAIPPEEPVNDTPDPLLVHAKVLVVDLEGTTSAAGFILGDLYDYARPRLAAWIDGHADDPAIAEARRQVIADAHLASDASTDEIVAVLHEWMERDVKATPLKTIQGQIWAEGFDRGEVTSHFFDDVVPRLRRWHDAGVGLAVFSSGSVASQVPWFKHSPSGDLTPLVTDFFDTVKAGPKKEAASYETIASALGVDAGDLVFFTDNPGEVSAAQEAGWQVVAFSREGEPFFEADFGTASVVASFDDVEVVAP
>NZ_CP020715.1|WP_085021326.1|820660_821725_+|methylthioribose-1-phosphate-isomerase
MTHRLQTPASARRAPLLDDSVRVVDGAVLILDRRVFPRSVEWVAAVDAEEVAAAIAGMVTQSSGPLYAAYAAMELTALQVADLDLDAAGRRMRRAAEVVATARPTNGHPREAVEHVLAAIDEAASTPQLVEAAVEAARDGSDLYRRRSRLLGDATVALLDDGARILTHCWMDTYLVETVRAAEAVGKSFEWVATETRPYLQGARLTSHTLAEMGQPVTLITDGMGAAAMAPGSGLGPIDALVTAADRVSLDGSVVNKVGTLGLAVAASAFGVPFYALVQAPDAGAPTADDIVVEERDGDEVLAVGGVRTASDLVTRGWYPAFDVTPARFVTRIVTDRGAFPADRVADYHRKQQA
>NZ_CP020715.1|WP_085018554.1|819776_820517_-|DUF2510-domain-containing-protein
MIDESRQDPGAGGGTPPPTEAPRADGEAPPARRTATGSYTATGSYTGTGGVVPAGWYVDPEAPDPATDRQRWWDGSRWTSHVRSSAAPPGPAGPGAGPGEVSLPSVPAGTPVYTPYIWIVTLLPLLSLALRPWVPGGPYSTVPLPAETGLRLVLPADPLGLTAAVSGTVAWLAGIVLAWLDHRVLLSRGFVRPFGWGWAIIPAPVYAIGRSVVARRPSGRGIAPMWVSIGILVVGSIVSTVLSQIR
>NZ_CP020715.1|WP_085018552.1|819039_819711_-|DUF2510-domain-containing-protein
MSDSGYGAQNDGAQGSGATPPAGWYPDPAGSGMQRWWDGARWTDNRQWPSAPAFQGGAGLDPNAKIAPGTPVYTPWIWLIVLLPLLSYALLPWVFRETMGQMESIMTSTQYGTTTRFGMSTLGPANVVSQLLGWVIWGLTVLFAWLDYRMLRMRGFVRPFHWAFAFIPAPVYAIGRSVVARRRSGRGIAPMWVAIGMLALGLIVTIVFVVATVIAVPLPSTYR
>NZ_CP020715.1|WP_085018567.1|830830_831340_-|hypothetical-protein
MSESAFAVGSMSRFHEIVSARSVLEAQDTMLAELHAEGFAVAAPSYADGIWSVRYAEIGDDRKSNWSEWGLEVFPLLSLVGVRRHIARCAAPVAVTPTATGSRLITHVVWGFRGDGGSVRYAARRLRDAAERASDRLGGVHREQLSPFDGDAPVHAKAFDRLTGWRHLR
>NZ_CP020715.1|WP_085018569.1|831493_832897_-|Nramp-family-divalent-metal-transporter
MPKDVAAVVDSSAPHGRPDGLTPRWWHSIALFGPAFVAAIAYVDPGNVAANLTSGAQFGYLLVWVLVLANAFAVLIQYQSAKLGVVTGRTLPELVGSRARPWTRRAYWLQAEVVAAATDVAEVIGGAIALNLLFGLPLVVGGLIVGVVSLGLLLVQAARRQRTFEFVIVGLLAVIAIGFLAGTFVAPIDWPAAAEGLVPRFDGTQSVLLAASMLGATVMPHAIYLHSGLARDRHHAELAHAAESGTVVHTGAAEPAAGPAAPSVAGVGTGVGAPGPRFAAEPSRLRTLLRATKGDVVGALVVAGAVNIAMLLLAAAALRGVEGTDSIPGAYQAIQAALGPVVATVFAIGLLASGLASTSVGAYAGSVIMAGLLRVRVPLLARRAVTLIPALVILALGVDPTYALVLSQVLLSIGIPFALVPLFRLTGDRALMGEFADGTVKRVVAWTVVALIVALNLVLIVLALTGA
>NZ_CP020715.1|WP_085018571.1|833025_834075_-|ABC-transporter-permease
MSGPTLARPAASAGERVSAFVVKWGFIAVTVALILYFVITEPNFRTVDNVFGMLKFIAPTAIAGLGVMLAMTVGGIDLSVGANAGFAVSIAAWTMVIGNQVGGIAVSVVLVCGLLIGAVNAFLVVVARIPDLLATLTTMFVIVGLKLIIVDGKSISSQMTLADGTTAPGRFTADFLWLDRGSIGPVPVPVILFFLVTLILWFVLERTRWGRALFAVGTNAEAARLAGVRVQWYRTAAYMACGLLASIAGLLLAARIGQGDVSAGNSLLLDAVAVALVGVSVLGIGRPNAWGTALGAVLIAVMVTGFSMLGLPYYAQDFGKGVVLLIALLFSFTFSRRRTVVTAGSTTSS
>NZ_CP020715.1|WP_085018573.1|834071_835796_-|sugar-ABC-transporter-ATP-binding-protein
MTIGSSAPAGRTPAEGHDVPVVSLTGVSVAYGSNLVLQDVTLDFHPGEITALLGANGAGKSTLIKALSGANSRYEGTVRLNGETVHLSSPTQARQLGISTVHQKVADGIVPGLSVAENLTLDDLAEATRHPLRSRGRQREDARRALATLGLDWPHSVLGQDAALLPISDAQLLVLARALRTTPRLLILDEPTSALTAAEADRLFGVLTSLRASGLSILYVSHRFGEIETLADRVVVLRDGRVQSDSARPFAWHEILHDMLGRATAVQHDRGTTLRGTETVASVDGVRLLPESAPLSLEIRSGEVLGVLGLIGAGKTEIAELLAGLARPATGGLTLAGHPYSPKRPGDALRAGVVLVPEDRQRQGILPGWSVLRNITLPFLAESSAVGVLRRRAERSRAERVIASLDVVTTGPEAFIDDLSGGNQQKVVVGRWLSASPRVALLDEPFRGVDIAARREIGARLATLAGDGGAAVVLSSDVDEILEVADRIVVLVGGEIALDAYADEVGRAEVIGAFLGADHAVEDPGSRLAGPSATADPPPAEPDHGAPSPDPAPDGSPSDPFRDDRGPSPERTEA
>NZ_CP020715.1|WP_085018576.1|835792_836908_-|substrate-binding-domain-containing-protein
MALSRRALRLRSVAVTAVAAASLLALSACSQSNGSPASTSGGQAAPATASAPLPAPFDGDPVKVALVRQSGAGDYFEAWGAGAQAQAKAANIDLTVTDARNDNAKQASDLEQAIASKPDAIIIDHGQTDTLQPLVTEAVTAGIPVVVYDLALNDTTGVISTSQSDESMASGVLDQLVKDVGDGAKVGYVSATGYAALDRRAAVWDEYVKDHDLDVVFSTGKVTESTATDNIPLVDAALKQNPDVQAIFAPYDEITKGTVQAVIQNNLQSKVKVYGIDISNADIEVLTQDGSPWVATSATDPAAVGAGVVRSLALSLAGQLDETEVTFPAITVTQQFLLDNGITNVQQLRDQEPTLLLDDTVTADWLPAVSG
>NZ_CP020715.1|WP_085018578.1|837078_837654_+|cupin
MTLLTVWNDTDPETPVLQTRDVDVITEQLNGLGARFSRWEVKELSADPTQDEVLAAYADEIAAVNAEHGYTYVDVMTMTPADTDEYREKAVASRAKFLNEHQHDDDEDRFFARGTGVFYLHVGGKVYAVYCEQGDVISVPVNTTHWFDMGLRPDYVSVRFFHDDDGWVGNFTGSEISAKFATHDELASVPA
>NZ_CP020715.1|WP_085018580.1|837735_839793_-|FUSC-family-protein
MADGEREDGWLRELARLKPARFPVALAVRTFLAAAVPLFLGLATGQFLLGLYVTLGALMTTTADRGGAYRTRFRQLLVTAPLGALGFTLGHVVAGHGWLTVVLLAAVGLLSGLLSGYGAAFSLGSMQMLVFTIVTVGVTSPLPWWVPSVLYLAGGLFTAVMLALESLVDRRRPERAALRSSIVALAELSAASDDGDDAAFERARQKLTDVTAAAYRTLLDTRARSEGRTLQADRDAVRLAGISEVSSALIAAHAAGQRTADATAWLSAMADALAKRGSRPPSPPEVDLESTQTLRRTLELAEAIWPRDRALSAATRSIPVVTSSSPAVARAASETRVPGAVGRATPLPVGPTAQPAGASVLSQLLVGRAVVTSAVRLALCIGIAAIAQHWVPGDRSYWIGLTVALVLKPDFGSVFARAVQRSIGTVIGVAIGVGILALVPKSELAILILIIALLAAVLPWSGQRGYGLQSIFLAPFVLLIFDLISPGPQTVDYGAQRLLDTVVGCVIVLVFGYLIWPRSLRSSLPVAVADAVDAVAAYVRGATVSEAPDPAAGAELRRRMTGLRRTAYRTLSDLRIQLQRSLAEPPPASREAKAWFPAVAAAERLCDRVTVYAQNRRRGGPQPDHEASEAVAAELEALSRLARSTAPRPGRWRADSADEAAGPEAMLDALERSATRFSAAVDTPA
>NZ_CP020715.1|WP_085021328.1|840059_841127_+|VIT1/CCC1-transporter-family-protein
MYDELAERRSGSEREILLSLAAAERRHQAHWVELLGDDVGKPVRADFRTRMLGVLAKRFGSVFVLALMQRAEARSPYETDDDATEAMAADERIHGEVVRALAARGRSRLSGTFRAAVFGANDGLVSNLALVLGMSATGVSNTVVLASGVAGLLAGALSMGAGEYVSVRSQRELLAASTPDPQASTAVPKLDVDANELALVYRARGMSEEEAEARARDVFSGLSSSTSAIRVVPSARPGDTEGDSSDGVGAAGGVDANLDEHEEIGTAWQASISSFLFFASGAVVPVIPYLFGLTGLVAVAVAAGLVGIALLGTGAVVGLLSGASPLKRAVRQLAIGFGAAAATYLLGLVFGATLG
>NZ_CP020715.1|WP_157127084.1|841312_841642_-|hypothetical-protein
MSDTSTPGDEPFFDREEAFEEANDLETNDAVAGETVWEGPGDGNDGPTGGSPREGAPDWSQQGDTQYRAPEAPEEEAPGEFPSDERLDPDLGPGVGDGPEQSDPDEETV
>NZ_CP020715.1|WP_174604394.1|841727_842936_-|acyl-CoA-dehydrogenase
MPEDQVLPPVVTSRADALALGRELADEFTSVAVSRDAEGTAPFDEVRRLRATGLLPAAIPASLGGGGLDWPTIFETIRPLARVDAGLGHVVAYHFLQSWRIRLNEETARIEALQRRSAERHWFWGGAGNPRDATLELTPVDGGFTVRGRKFFATGAQVSDRIVASATRTDDDEKYAIVIDAHLPEVVHHDDWDNIGQRLSASGSVSFEDAFVPDEHVLGPSEQAGARYRPYASLSGLSFQLALAHLQVAIAEGALAVAADYVRNGTRPWGTSGVDRAVDDPYTRELTGRLASATRASDALVWRATDLFAAAEEKGWELGDDERGELSIELSAAKVETSRLALDVSSRVFDLTGARATASRYGFDRFWRNARTLTLHDPAVYKAREVGDRLLTGEFPEPSGYS

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Crispr_ID: NZ_CP020715_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_3

1150150-1150336

Orphan

Consensus_repeat	Method
AGGCGCGGCTGGGCAGCGGTGCGTCCCGCGCCTTCTGGGTGTGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_3

>merge|NZ_CP020715|3|1150150-1150336|CRISPRCasFinder
AGGCGCGGCTGGGCAGCGGTGCGTCCCGCGCCTTCTGGGTGTGTGCGCCGTGTGTCGCGAGTGCACCCAGCAGGCGCGGCTGGGGAGCGGTGCGTCCCGCGCCTTCTGGGTGTGTGGGCCGTGCCTCGTGAGTGCACCCAGAAGGCGCGGCCGGGGAGCTGTGCATCCCGCACTTTCTGGGTGTGTG

>NZ_CP020715|3|3|1150150-1150336|CRISPRCasFinder
AGGCGCGGCTGGGCAGCGGTGCGTCCCGCGCCTTCTGGGTGTGTG	CGCCGTGTGTCGCGAGTGCACCCAGCAGGCGCGGCTGGGGAGCGGTGCGTCCCGCGCCTTCTGGGTGTGTGGGCCGTGCCTCGTGAGTGCACCCAGA
AGGCGCGGCCGGGGAGCTGTGCATCCCGCACTTTCTGGGTGTGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085018863.1\|1150634_1152533_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|340391
NZ_CP020715.1\|WP_085018858.1\|1143409_1143922_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|237597
NZ_CP020715.1\|WP_085018867.1\|1156978_1157245_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_174604407.1\|1161021_1162059_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP020715.1\|WP_085018871.1\|1160116_1160809_+\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_CP020715.1\|WP_085018868.1\|1157321_1157702_+\|cold-shock-domain-containing-protein	unknown	unknown	gnl\|CDD\|239905
NZ_CP020715.1\|WP_085018865.1\|1153319_1154960_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP020715.1\|WP_085018862.1\|1148442_1150062_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP020715.1\|WP_085018864.1\|1152543_1153236_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP020715.1\|WP_115364510.1\|1145865_1146267_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|376583
NZ_CP020715.1\|WP_085018866.1\|1155089_1156982_-\|helicase-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|379300
NZ_CP020715.1\|WP_157127104.1\|1146970_1147261_+\|DUF3263-domain-containing-protein	unknown	unknown	gnl\|CDD\|378688
NZ_CP020715.1\|WP_157127411.1\|1143991_1145185_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP020715.1\|WP_085018860.1\|1147268_1147868_+\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163
NZ_CP020715.1\|WP_085018861.1\|1148049_1148253_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP020715.1\|WP_174604406.1\|1145316_1145844_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380312
NZ_CP020715.1\|WP_157127413.1\|1146358_1146805_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NZ_CP020715.1\|WP_174604569.1\|1158178_1158823_+\|DUF3027-domain-containing-protein	unknown	unknown	gnl\|CDD\|378605
NZ_CP020715.1\|WP_085018870.1\|1158910_1160026_-\|phosphoserine-transaminase	unknown	unknown	gnl\|CDD\|130433
NZ_CP020715.1\|WP_085018857.1\|1142282_1143185_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085018863.1\|1150634_1152533_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	1.34176e-34
NZ_CP020715.1\|WP_085018858.1\|1143409_1143922_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|237597	PRK14054, PRK14054, peptide-methionine (S)-S-oxide reductase.	1.38039e-114
NZ_CP020715.1\|WP_174604407.1\|1161021_1162059_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	7.23953e-17
NZ_CP020715.1\|WP_085018871.1\|1160116_1160809_+\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	1.31801e-44
NZ_CP020715.1\|WP_085018868.1\|1157321_1157702_+\|cold-shock-domain-containing-protein	gnl\|CDD\|239905	cd04458, CSP_CDS, Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.	3.68963e-17
NZ_CP020715.1\|WP_085018865.1\|1153319_1154960_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	1.48937e-104
NZ_CP020715.1\|WP_085018862.1\|1148442_1150062_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP020715.1\|WP_085018864.1\|1152543_1153236_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.35951e-87
NZ_CP020715.1\|WP_115364510.1\|1145865_1146267_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	8.5272e-79
NZ_CP020715.1\|WP_085018866.1\|1155089_1156982_-\|helicase-associated-domain-containing-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	1.96182e-22
NZ_CP020715.1\|WP_157127104.1\|1146970_1147261_+\|DUF3263-domain-containing-protein	gnl\|CDD\|378688	pfam11662, DUF3263, Protein of unknown function (DUF3263). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.23144e-30
NZ_CP020715.1\|WP_157127411.1\|1143991_1145185_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	8.89453e-87
NZ_CP020715.1\|WP_085018860.1\|1147268_1147868_+\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	1.07174e-12
NZ_CP020715.1\|WP_085018861.1\|1148049_1148253_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.02159e-32
NZ_CP020715.1\|WP_174604406.1\|1145316_1145844_-\|nitroreductase-family-protein	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	4.57721e-33
NZ_CP020715.1\|WP_157127413.1\|1146358_1146805_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	4.10296e-36
NZ_CP020715.1\|WP_174604569.1\|1158178_1158823_+\|DUF3027-domain-containing-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.57417e-25
NZ_CP020715.1\|WP_085018870.1\|1158910_1160026_-\|phosphoserine-transaminase	gnl\|CDD\|130433	TIGR01366, Putative_phosphoserine_aminotransferase_PSAT., phosphoserine aminotransferase, putative. This model represents a putative variant form of the serine biosynthesis enzyme phosphoserine aminotransferase, as found in Mycobacterium tuberculosis and related high-GC Gram-positive bacteria. [Amino acid biosynthesis, Serine family].	0
NZ_CP020715.1\|WP_085018857.1\|1142282_1143185_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	8.36935e-18

>NZ_CP020715.1|WP_085018862.1|1148442_1150062_+|chaperonin-GroEL
MAKIIAFDEEARRGLERGLNTLADAVKVTLGPRGRNVVLEKKWGAPTITNDGVSIAKEIELDDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGADPISLKKGIEKAVAAVSAQLAANAKEIETKDEIAATASISAADPEIGAIIAEAIDKVGKEGVVTVEESNTFGTELELTEGMRFDKGYLSQYFVTDPERQEAVFEDPYILIVNSKVSNIKDLLPIVDKVIQAGKQLLIIAEDVDGEALATLVVNKIRGIFKSVAVKAPGFGDRRKAQLQDIAILTGGQVISEEVGLKLENVTLDLLGQARKVVITKDETTIVEGAGDPEAIAGRVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALIQAGTAAFDTLELSGDEATGANIVKVAIEAPLKQIAFNAGLEPGVVAAKVRELPAGHGLNAATGEYVDLLAAGIIDPAKVTRSALQNAASIAGLFLTTEAVVADKPEKAAAAPADPTGGMDF
>NZ_CP020715.1|WP_085018861.1|1148049_1148253_+|cold-shock-protein
MANGTVKWFNAEKGYGFITVDGGGQDVFVHYSAIDMSGYKVLEEGQQVVFDVGSGSKGPQAESVRLA
>NZ_CP020715.1|WP_085018860.1|1147268_1147868_+|LytR-C-terminal-domain-containing-protein
MAQHTLDSFDHLPASTSRVGAHRGPKPRGRGWIVFAWAALATALLVGAGVTYLAVVNNSIQFDGILGADSTSSAAPVETPTPTPTVTPAVDPQATVTVLNGTDVAGLAGAVGQAVVANGWAEPTVANASETDVATSTVYYADPAAEAAALAMSQQLGIPVSLSSAFPGATLTVVIGADYAGPGSEGLVPSGEGESDTVG
>NZ_CP020715.1|WP_157127104.1|1146970_1147261_+|DUF3263-domain-containing-protein
MVMPADHAARADERSLSGRDVRILKFERSWWRHAGQKESAIRKEFGLSSARYYQVLSALIDSPAALAHDPMLIKRLQRMRDERLAARSARLLPHDD
>NZ_CP020715.1|WP_157127413.1|1146358_1146805_+|GNAT-family-N-acetyltransferase
MTQKTWSELEPIEVYGIAKLRTDVFFVEQKVDEEELDWRDVEPTTVHLFIKDGRNVLAYLRVLHDEVAEHGGAHRVIGRVVVDRAHRGEGLARILLGRATDLFGDEPMLLHAQSYIAPLYVRAGFEAFGEEYVEAGIPHISMLRPPSA
>NZ_CP020715.1|WP_115364510.1|1145865_1146267_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MTYEVSKTDAEWRDELDRDEYAVLRQAATERPWTGKLLDEHREGVYRCRACGAELFRSETKFDSHCGWPSFYDPSESDAVELIQDRSLGMVRTEVRCASCGSHLGHVFDDAPQTPTGDRYCMNSISLTFEPAA
>NZ_CP020715.1|WP_174604406.1|1145316_1145844_-|nitroreductase-family-protein
MLARRSMSRVTDAAPTRAQLRELVEAAGQVADHSGLRPWRIIELRGDDRDVLGRALAKADGRSKKDAVKHVAKARRAPLVLAIVASYRRSKVARWEQEAVASGVAHALSLVLHDEGWGVFWRTGSTTRHKAVRKAHRLDKDEELLGWLYVGGIPETGRRPRPRNRIRVERHLSTL
>NZ_CP020715.1|WP_157127411.1|1143991_1145185_-|MFS-transporter
MSTARRWAALLALALGGFGIGVTEFATLGLIPDLASDLLPDAYSADPASANATAGILVSVYALGVVVGAPTITALAARVSRKRLLLVLLGVFVVGNLLSAVLPSFGLVMAARFVSGIPHGAYFGVASLVAASLMGPGKRAMGVSLVLSGLTVANIVGVPLGTFVGQTFGWRTTYLMVTLIFAVTLVFVLIAVPFRRGDPTATVKNELSAFRRPLVWLTLLMGSVGFGGMFAVYTYVTPLTTDVTGLDASFVPIVLVVFGVGMTVGNLLGGWFTDHGVKRSLIVAMGGLGLSVLALGLTSASPVGLIASILFVGFFVGGAGPAVQTRLMDVSRDAQSVAAALNHSALNIGNSLGAYLGGLVIAAGLGYTSPAFVGVALATAGILVALISFAVERRRGR
>NZ_CP020715.1|WP_085018858.1|1143409_1143922_-|peptide-methionine-(S)-S-oxide-reductase-MsrA
MTEKAVLAGGCFWGMQDLIRKRPGVVSTRVGYTGGDVENATYRNHGTHAEAIEIEFDPTATSYRELLEFFFQIHDPSTKNRQGNDVGTSYRSAIYYTDDEQRSVAEDTIADVDASGLWPGKVVTEVEPAGAFWEAEPEHQDYLERIPWGYTCHFARPGWVLPRRSESVAS
>NZ_CP020715.1|WP_085018857.1|1142282_1143185_+|thioredoxin-domain-containing-protein
MTSGRPQDARMSKNERREAAREKAKQLREQQRKKDIRNRAILIGSLSVVVVAIIVGVTLVIVSTLKPAGPGPANMASDGIVIGENFVAQTTPGLQPGESPVAAATSDPNVADIRVYLDYMCPYCGQFEATNNEQIGQWVSSGAATVEIHPISILDRGSQGTKYSTRSANAAACVANYSPDQFWAFNTLMFQNQPEENTSGLDDDTIKGLVSQAGAQNLDQIDSCIDDGEFKSWVADSTSRALQGPLPGTSEEKVTGTPTVLVNGQKYSGSLTDANAFSAFVVQVVGSAESTPTPTPVPAG
>NZ_CP020715.1|WP_085018863.1|1150634_1152533_-|HAMP-domain-containing-histidine-kinase
MHNALLKQWNSISLRTKITGVTVLMLTFGLVVSGIGTMLVLRSYLLTQVDSQLDSAAKDPSPFLGPGAEPGEFKLQDIQSAPDDYFVGLYDASGNLLISNWGANDTNAMPSAAVSLDSTNLLEGKVFTTESLDQRTEWHAVSTIVYIGTDGSQGSIVIAQALTATERTTATYLSIFLAFGIGVVILGAMLTRLLVTSTFGPLRAVERTAAAIADGDFSQRLSDDIPNTEVGRLNRSLNTMLSRIDRAFADRARTIDQMRRFVGDASHELRTPLVSVRGYAELYRMGALQTPEDVASAMERIEKEAIRMSTLVEDLLELARLDETRPLQLSRVDLVPLAMDAAMDARASSPQRVISVITPLGPSEVAITPVLPALDAAPAPAPAPASSSESSAVAPESAPAPTGVAPAKPPRGVSTATRPIAALGARLRRRGRTAPVPIPGIAQSADETAPIPTASLTRPIVLAEENKIRQVIANLVGNALRYTPDDSPIDIAVSADDTRRVAVLDVIDHGEGIPPQIREKIFQRFWRADTSRARETGGSGLGLAIVASIVATHQGTVEALETPGGGATFRVTLPLVPVPGSPAPTPRDARAAAAASAATPPASASASASATPTDADGDEGEGPSSTTTAYLS
>NZ_CP020715.1|WP_085018864.1|1152543_1153236_-|response-regulator-transcription-factor
MTGPRILIVDDEPNIRDLLTTSLRFAGFAVRAVNNGAQTISAVLEEEPDLIILDVMLPDMNGFGVTKRLRAAGYTAPILFLTAKDDTEDKITGLTVGGDDYVTKPFSLDEIVARIKAILRRTMQADEDAIIRAGDLTMDQDTHEVFVGDVAIELSPTEFKLLRYLMLNPNRVLSKAQILDHVWEYDFNGDAGIVESYISYLRRKLDAHTDESLIQTKRGFGYMLKVSKAS
>NZ_CP020715.1|WP_085018865.1|1153319_1154960_-|DEAD/DEAH-box-helicase
MPNGPLIVQSDRTVLLEVAHPDAEAARHELAAFAELERAPEHVHTYRVTRLGLWNARAAGHTSDEILGVLERWSKFPVPQAVSVDVAETVARYGRLVIDRRDDGELVLRSTEPAILSEIARGKRVAPLLTGRVDDTSYTVQAWARGQLKQELIKLGWPADDLAGFTPGTPHDIDLDETAWHLRDYQQQAVTSFVDHGSGVVVLPCGAGKTLVGAGAMAEIKANTLILVTNTVSARQWRSELLRRTSLTEDEIGEYSGAVKDVKPVTIATYQILTSKRGGAYRHLELLDALDWGLIVYDEVHLLPAPVFKLTADLQARRRLGLTATLVREDGRESDVFSLIGPKRYDAPWKEIEAQGYISPAECFEVRVDLSHSERLEYAAAADDERYRLAASAPEKLAATRELIDRHPGEQVLVIGQYLDQLEALSEALDVPQITGATPVDERERLFQAFRDGEERILVVSKVANFSVDLPEASVAIQVSGSFGSRQEEAQRLGRLLRPKESGHTASFYTLVTRDTVDAEFAQNRQRFLAEQGYSYRILDADTIAA
>NZ_CP020715.1|WP_085018866.1|1155089_1156982_-|helicase-associated-domain-containing-protein
MSAPLDLARELSARDADDLATLLTAREIGGRSLRDLFDLADALLDDASILAALAPLPRGALERLAAGEPLDASEASSASDVSSASDVSSASDTDEADDADPSESARTARRLALIDQHGRPFAPVVAVAARVLADAPRAEHPSDDALPAPTDPAVGTDPSIGTTPSVEADAAERATAAVLGVHELLDVLRGSRVRWRARGGIAVADERRLSTDLDPQHADVSQLAQLALDAGLAAVESDLLLPTDEAASWSTLPAPERWHRLLVGWFRALPRPLASVVIDRPSLLADPSALLTALRAAFPAVSAEVVEAVPTATAMADALGLVASGHPSSLGNALSGSAGPEAFAGSFPTPVDRVYLLDDLSIVSPGPLAPDLDARLRELATVESRGLATTYRISRGSLDRALSAGVTEERMRDLLVRLSLTGIPQALDYLLREAAAAHGRLRVESVDGDTLIKADEARLTEEISVHQSLSALRLERIDAATLRTSRARDAVYWMLVDAGYAPSAWQDGREVPLSRARIAHPPQTEGTLDGSPRTEALQVATRLLAATPPMVDDTSAWNTRELERALRARERVRLGVRMPDGTLRVIVALPLGLSGGRLRFSDTGAGVERTVPLRSIDDVAPETDAAGAST
>NZ_CP020715.1|WP_085018867.1|1156978_1157245_-|hypothetical-protein
MSDDQRQPASRLQRTLGFMIISVIGLSVLCFFAIIIATAVGVHDFTPAPWPVIGLLPVIGLPIGFVLIFVLLIISIRARGRENRNGGR
>NZ_CP020715.1|WP_085018868.1|1157321_1157702_+|cold-shock-domain-containing-protein
MPTGKVKFYDEEKGFGFVSTDDGQEVFLHASALPAGAKVKAGTRLEFGIADGKRGAQALSARLLEAPVSMVKMSRKPADDMAVIVEDLVKVLDAVGGNLKRGRYPDNAHSRKVATLLRRVADELDA
>NZ_CP020715.1|WP_174604569.1|1158178_1158823_+|DUF3027-domain-containing-protein
MYEPDPVLLESVELARAGLREITDDSTIGDVVGFQAQGEHVLSIHFATTLRGYPGWHWTATLARVDDGSEPTVLETELLPGEDALLAPDWVPWSERLAEWRAAQAAAAEAAAEEEPEESDDESEESDDALDEDSLDDDDSDDDDDDSTDDDDSDDSDDDEDSLDDDALDDLDEDDLVDDVLDDLDDLDDEALDPDAASSPEDAASSSDEADDRP
>NZ_CP020715.1|WP_085018870.1|1158910_1160026_-|phosphoserine-transaminase
MATIEIPRDLLPIDGRFGCGPSKVRGEQLEALVTRGASLLGTSHRQAPVKDLVGSVRSGLADLFALPDGYEVLLANGGSTAFWDSAAFGLIEKRAENLSFGEFGSKFAKAAGAPWLEKPHVITAEGGSRAEVEVVDGVDVYAWPHNETSTGVMAPVRRVNGDEGALTVIDATSAAGGAFVDPAEADVYYFAPQKNFASDGGLWLAFFSPAAIERVERIAASDRYIPEFLSLKNAVDNSRLNQTLNTPAVSTLVLLDEQISWINANGGLSWAAARTKESSDALYAWAEGVDYARPFVSEPDHRSQVVVTIDFDDAIDAAAVAKTLRANGIVDTEPYRKLGRNQLRIATFVAIEPADVRKLISCIEYVVSHLG
>NZ_CP020715.1|WP_085018871.1|1160116_1160809_+|metal-dependent-transcriptional-regulator
MTDLIDTTEMYLRTILELEEENIVPLRARISERLGHSGPTVSQTVGRMERDGLVVVSGDRHLELTEPGRRKAVSVMRKHRLAERLLSDVIGLDWELVHEEACRWEHVMSEQVELRILDMLDHPRESPYGNPIPGLDAFGEEATAPFTKGVVNIVTLVHGAVGPQRKTIRRLGEPAQTDPELLLQLKQSGVVPGNTAAFSSAGSYVLVEVDGFEQGLELPNEVASHIFVGV
>NZ_CP020715.1|WP_174604407.1|1161021_1162059_+|C40-family-peptidase
MASAGDALDPTSTDTTRAAHGSAADQPLTRRERREREARTTAGTDRGNAIVLSSKATAVVRSAAATTAAASAHRAPVATATPSVPVAKEPIAASSAVVPAAFSARQQRARLRLPRKRTVAAGFVMALAAGMFATTALPAYAYGGGGSFDPEATSTAFGEDQTLQIPNATAILTVSRDGYTAPTPEELAAAEQAAQAAAQAALDAERAAAATPATSGSSASRSPFAVTPPSSAYSGAAVVAYAQQFVGVVPYGTGNSPDTSFSCDGLTQYVMGAFGISLPRGVSAQAALMVQIDPADAQPGDFLVYPGQHIGIYAGGGMMIDSPDWGRYVEYRGIWGSPYYARYVG

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Crispr_ID: NZ_CP020715_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_4

1317125-1317276

Orphan

Consensus_repeat	Method
CGCGGGACGCGCCGTCACGCCGCCGCCTCCCGCGAGCGTGATCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_4

>merge|NZ_CP020715|4|1317125-1317276|CRISPRCasFinder
CGCGGGACGCGCCGTCACGCCGCCGCCTCCCGCGAGCGTGATCGCCGCCGCCCCTGCGGCGAGATGCGGCGGAGTGTGGGCCACTCCTGTGTGCGCCGCCCTCGACCGCGGGACGCGCCGTCACGCCGCCGCCTCCCGCGACCGTGATCGCC

>NZ_CP020715|4|4|1317125-1317276|CRISPRCasFinder
CGCGGGACGCGCCGTCACGCCGCCGCCTCCCGCGAGCGTGATCGCC	GCCGCCCCTGCGGCGAGATGCGGCGGAGTGTGGGCCACTCCTGTGTGCGCCGCCCTCGAC
CGCGGGACGCGCCGTCACGCCGCCGCCTCCCGCGACCGTGATCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085021378.1\|1306072_1307125_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP020715.1\|WP_085018998.1\|1324459_1325026_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274678
NZ_CP020715.1\|WP_085019000.1\|1326656_1328717_-\|glycogen-debranching-protein-GlgX	unknown	unknown	gnl\|CDD\|200465
NZ_CP020715.1\|WP_085018994.1\|1314306_1316100_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_157127119.1\|1308820_1309600_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380090
NZ_CP020715.1\|WP_085018991.1\|1310319_1311948_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_CP020715.1\|WP_085019001.1\|1328784_1329969_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP020715.1\|WP_085018989.1\|1307121_1308768_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP020715.1\|WP_085018996.1\|1317456_1319688_-\|1,4-alpha-glucan-branching-protein-GlgB	unknown	unknown	gnl\|CDD\|235445
NZ_CP020715.1\|WP_157127424.1\|1325067_1326555_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP020715.1\|WP_085021381.1\|1319687_1321676_-\|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase	unknown	unknown	gnl\|CDD\|200482
NZ_CP020715.1\|WP_085018995.1\|1316096_1317050_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225660
NZ_CP020715.1\|WP_085021380.1\|1312306_1313026_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225496
NZ_CP020715.1\|WP_085019002.1\|1330255_1331239_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|377028
NZ_CP020715.1\|WP_085018992.1\|1312005_1312296_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085018993.1\|1313061_1314147_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP020715.1\|WP_085019003.1\|1331391_1332534_+\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP020715.1\|WP_085018997.1\|1321885_1324447_+\|alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340852
NZ_CP020715.1\|WP_085019004.1\|1332530_1334903_+\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP020715.1\|WP_157127120.1\|1309601_1310270_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|380090

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085021378.1\|1306072_1307125_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.57948e-81
NZ_CP020715.1\|WP_085018998.1\|1324459_1325026_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|274678	TIGR03613, RutR, pyrimidine utilization regulatory protein R. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the TetR family of transcriptional regulators defined by the N-teminal model pfam00440 and the C-terminal model pfam08362 (YcdC-like protein, C-terminal region).	1.39322e-10
NZ_CP020715.1\|WP_085019000.1\|1326656_1328717_-\|glycogen-debranching-protein-GlgX	gnl\|CDD\|200465	cd11326, AmyAc_Glg_debranch, Alpha amylase catalytic domain found in glycogen debranching enzymes. Debranching enzymes facilitate the breakdown of glycogen through glucosyltransferase and glucosidase activity. These activities are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in Escherichia coli and other bacteria. Debranching enzymes perform two activities: 4-alpha-D-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33). 4-alpha-D-glucanotransferase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-alpha-1,6-glucosidase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. In Escherichia coli, GlgX is the debranching enzyme and malQ is the 4-alpha-glucanotransferase. TreX, an archaeal glycogen-debranching enzyme has dual activities like mammals and yeast, but is structurally similar to GlgX. TreX exists in two oligomeric states, a dimer and tetramer. Isoamylase (EC 3.2.1.68) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen and their beta-limit dextrins. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP020715.1\|WP_085018996.1\|1317456_1319688_-\|1,4-alpha-glucan-branching-protein-GlgB	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NZ_CP020715.1\|WP_157127119.1\|1308820_1309600_+\|hypothetical-protein	gnl\|CDD\|380090	pfam18013, Phage_lysozyme2, Phage tail lysozyme. This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.	3.48536e-05
NZ_CP020715.1\|WP_085018993.1\|1313061_1314147_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	7.01403e-34
NZ_CP020715.1\|WP_085018991.1\|1310319_1311948_+\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	2.13654e-63
NZ_CP020715.1\|WP_085018989.1\|1307121_1308768_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NZ_CP020715.1\|WP_085019002.1\|1330255_1331239_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	5.97826e-14
NZ_CP020715.1\|WP_157127424.1\|1325067_1326555_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.26724e-73
NZ_CP020715.1\|WP_085021381.1\|1319687_1321676_-\|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase	gnl\|CDD\|200482	cd11344, AmyAc_GlgE_like, Alpha amylase catalytic domain found in GlgE-like proteins. GlgE is a (1,4)-a-D-glucan:phosphate a-D-maltosyltransferase, involved in a-glucan biosynthesis in bacteria. It is also an anti-tuberculosis drug target. GlgE isoform I from Streptomyces coelicolor has the same catalytic and very similar kinetic properties to GlgE from Mycobacterium tuberculosis. GlgE from Streptomyces coelicolor forms a homodimer with each subunit comprising five domains (A, B, C, N, and S) and 2 inserts. Domain A is a catalytic alpha-amylase-type domain that along with domain N, which has a beta-sandwich fold and forms the core of the dimer interface, binds cyclodextrins. Domain A, B, and the 2 inserts define a well conserved donor pocket that binds maltose. Cyclodextrins competitively inhibit the binding of maltooligosaccharides to the S. coelicolor enzyme, indicating that the hydrophobic patch overlaps with the acceptor binding site. This is not the case in M. tuberculosis GlgE because cyclodextrins do not inhibit this enzyme, despite acceptor length specificity being conserved. Domain C is hypothesized to help stabilize domain A and could be involved in substrate binding. Domain S is a helix bundle that is inserted within the N domain and it plays a role in the dimer interface and interacts directly with domain B. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP020715.1\|WP_085021380.1\|1312306_1313026_+\|alpha/beta-hydrolase	gnl\|CDD\|225496	COG2945, COG2945, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	1.41539e-19
NZ_CP020715.1\|WP_085018995.1\|1316096_1317050_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|225660	COG3118, COG3118, Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones].	1.05035e-45
NZ_CP020715.1\|WP_085019003.1\|1331391_1332534_+\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP020715.1\|WP_085018997.1\|1321885_1324447_+\|alpha-glucan-family-phosphorylase	gnl\|CDD\|340852	cd04299, GT35_Glycogen_Phosphorylase-like, proteins similar to glycogen phosphorylase. This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism.	0
NZ_CP020715.1\|WP_085019001.1\|1328784_1329969_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	9.97471e-141
NZ_CP020715.1\|WP_085019004.1\|1332530_1334903_+\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP020715.1\|WP_157127120.1\|1309601_1310270_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|380090	pfam18013, Phage_lysozyme2, Phage tail lysozyme. This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.	7.77812e-05

>NZ_CP020715.1|WP_085018995.1|1316096_1317050_+|tetratricopeptide-repeat-protein
MSMTPPLPGNLRGAVDLSSLVSRAQAPAPTAGGPAGEGAGGASSLIVSASDANFPQIVELSNTVPVLVDLAAPWAEPSQELSAVLDRVVASYGGRLVLARVDVEASPQIAQAFQAQSIPTVAAIIGGRPVGLFAGVYPEDQIRDVIEQVLQLAQQNGVTGTVPVEGGPAEGDAAEPVEEPLPPHHAEAYEAISTGDYDTAIAEYQTAIAQNPRDSLAVAGLAQVQLLKRLDGVSLDDVRSDAAAHPDDLDAQLLVADLDVSGGHIDDAFGRLLDLFPKQDQAGKDRIRARLLDLFEVVGTDDPRVAKARTRLAGLLF
>NZ_CP020715.1|WP_085018994.1|1314306_1316100_+|hypothetical-protein
MRFILAILAFIIATALIGYGVAQRTVFLPPSTVESTVQTDDGVNYAVIDSEALRSHDGAQTLTVSSGNGGQVFAAYGRTADVEAWLQGSAYDRIGAGADGRGLVVESVAADPDGAENVASGSADPAASDLWLERFTSQGTLYRTLNLPEGYSVILASNGTDPAPAEVTISWPVSNATPWVGPTLVAGLVFLLAGIVLLILGLIHMRRSHGPRRKPPALPKGKRFSSSRTNAIESSVARRRRSLKAPMAVGVPIALASALVLSGCSPDYWPQPEAAAPTPVETIDATPAPTAVPDDDTPEPVVTSDQFAAILADVSSVAAEADASANRDLLTSRFEGPALDLRAATYAIRAGFPEYAAPQPIPANPVQVLLPQATDSWPRTAFAIVGGDDPSVPPVALFLTQDTPRADYKVYYEIALEPNTTLPEVAAATVGTTRLGPESKLLAMTPDQIKTAYSDILLNGDSSQYASMIDPTGDTLRSQVGADYKNTTKSGLSATAAIEFASVAAQGESIALATSDSGALVAVDIGETTTVKPVQAGATIKPEGAVKALSNVTETGKGTEATYDYQLLFYVPPQGTPDAKAQLLGFTQGLLSAKELP
>NZ_CP020715.1|WP_085018993.1|1313061_1314147_-|AI-2E-family-transporter
MKIQNAFTLGLVATLGVGVGLLIIGAVASLATILTYVGVALFIALGLDPIITWLERKRWPRWLALVTVLIVVLGIVTGLVFAVVPIIVEQTSQLITTVPEVVNRVLDERWRESLTQQLGGFIDINEVYNAVVSYFQDTSNITALAGGALQVGIGIASGAFGVVIVLILTLYFTASLNSMKRAAYRLVPASRRERFADLAEQITHSVGRFVVGQISLGLINGILSFIFLSIIGAPFPAVLAFLAGMLSVIPLVGTISGSVIIVLVCLIPGLSTGNGLIPGLSTPILALVAGIYYIVYMQVEAYVLSPRIMNRAVSVPGALVVIAALAGGTLLGVLGALVAIPIAASILLIIKQVVIPLQNER
>NZ_CP020715.1|WP_085021380.1|1312306_1313026_+|alpha/beta-hydrolase
MEIRSTTLLPAVREDVELHTADGLTLVGELAVPDGRPPVATLVTLHPLPTGGGFMDSHILRKAAARLPALADLAVLRFNTRGTSSPRGTSEGSFDHGEGERHDLDAAMAFVRERGLPHPWLVGWSFGTELALKYGARHEIDGAILLSPPLHRTSAAEVAAWDGNGKRLVALIPELDDYLRPPEARERFSGVSDIELVEVEGGKHLWVGENQTRRVLDEIVARVNPAVPLPLPTVYHLPD
>NZ_CP020715.1|WP_085018992.1|1312005_1312296_+|hypothetical-protein
MPRRHRPRPTGDDPDERLERLVAGWRRVEVRRGVEWNVQPVSGASAVKEYVCPGCGRAVEPGTAHLVAWRADGVLGDASDLAGRRHWHAHCWKIGV
>NZ_CP020715.1|WP_085018991.1|1310319_1311948_+|sodium:proton-antiporter
MRPEIIAVIGLIVIVALAALAPKLRLATPLVVVIVGLGVSLIPGVPPITIPSEWVLAVVLPPLLYSSAINVPLVDFRKNIGSITVLSVVLVFASAFIIGLGLWAIVPEIGFPAAIALGAVISPTDAVAATSIGKRLGLPPRLIATLEGESLVNDASALVLLRSATVAISGGVAFGGVVVDFFTSAGIAVAIGLVVGFLAVFVRSRLRDSVLNTALSFTIPFVAYLPTEVLNASGVLAVVVAGLYTGHHGARRFTAVTRLSERLNWRTINFLLENGVFLLMGLALKEIVTTAVVRDHGAASLDATGAILFGVLAALALLGIRFGFVAPLLFVQRWWAGRRRAAGPPHEGPVGMRGSLVLTWAGMRGVVTVAAAQSLPENTPFRAQLILIAFTVAVVTLLGQGMTLPAVIRLSGVRGVDKAADEESFATLVDELREAGEETLRAESVQLPSGESVDPTVIDRVRTDAQLRSESVWENARESDEDASTPHRQYRELRLEVLKAERGALLDARSRGDYPSRVLARAQTMLDQEEARLYQAVGDDDE
>NZ_CP020715.1|WP_157127120.1|1309601_1310270_+|transglycosylase-SLT-domain-containing-protein
MSLKRDVHPGVRIGLQVVAFGVAAAFVGLFALQPRTASLANAAYYAPDNAVGSSASQSLATSGSASSTVSRDGYQVTEPPAPEPVVAPVAVTSGSGSSSSTGSGGAPADCRALSVPQPGPPEPGTPKDAGYQAVLAHGWDVQEYYYLLALWNRESGWNPSAENTSSGAYGIPQALPGSKMAAFGDDWQTNPATQIAWGLSYISGRYGTPCEAWASSEERGWY
>NZ_CP020715.1|WP_157127119.1|1308820_1309600_+|hypothetical-protein
MGKHGLEDARSTSRPGRGGAAHRTTATAARPGSTTVSARAAAAPAPVTTRRPSRRSTAQRVGLQVVGLSAVAACAFVFVSGPNTVASATQFQGTFADYTPDGQVIAVDSAAGASVSRDAYSVVAPPPPPPVVASTPTTGSSSGSASSDSSCPTPDVTADPEGAKAIALELAAARGWTGAQYDALVALWSRESGWRLNALNKSSCAYGIPQALPGSKMASAGADWQTNPATQITWGLNYIAGAYGDPISALAHSDASGWY
>NZ_CP020715.1|WP_085018989.1|1307121_1308768_+|ABC-transporter-ATP-binding-protein
MSVVDVKDLRVTFRGGSREVRAVHGVSLAVESGEVLAIVGESGSGKTVTARTMLGLLPETAAVSGAVVLSTASDGSVDVVAVTGSRLRELRGRDVSMVFQEPSTALNPVYTVGWQIAEGLRAHGRLSRAEAKRRAIDILRVVGIPDPETRVDHYPHQFSGGQKQRIVIACALVQRPGLIVADEPTTALDVTVQAEILDLLRRLRDELGTAIVLITHNMGVVADLADRVAVMYDGEVVEQADVRTLFASPQADYTKALLAAVPRVGARTQERRRAVSSATPVVEADRVEIEYAGRFGRRAFRAVDGVSFRIAPGEVLGLVGESGSGKTTIGRAIGGLTRATGGSLKVLGTEMVGFSERAFKPLRADIGFVFQDPAASFNPLLTIADAVAEPLVIHGRARSTAQARPRVDELLEAVQLPRAYGDRFPHELSGGQRQRVSLARALALEPKLVIADEPTSALDVSVQARVLELFAELQSSLGFACLFISHDLAVVDLLADRIAVLYHGKLVEEGDAAEVLGSPQHEYTKRLLESLPVPDPVEQAARRAARTS
>NZ_CP020715.1|WP_085021378.1|1306072_1307125_+|ABC-transporter-permease
MKPEPISAAVPERPDLWHRIPVIKQLRQSSGLQRGMLIAGLVITAIFVLMAIFAPLLAPFGFAQLRDADGAFGAQQPPSAAHPMGTTVGGYDVLSRVIWGAQTALLVIVMAVVFSIVIGILLGLVSGYIGGWLDRVLVVIGDAIYAFPSLLLAIVLSIVISGGQSSLWGGITAAALSITVIYIPQYYRVIRAETMRIKAEPYVESARMLGASAPRIMFRHVLRNATRTLPVLFTLNSSEAILTLAGLGFLGFGIEPTAAAEWGYDLNKALSDVTSGIWWTALYPGLAIVVSVLGITLVGESMNDLSDPRLRGRRASRRSRRHDRSAGSAAASSSDATMATGAADTKEAGA
>NZ_CP020715.1|WP_085018996.1|1317456_1319688_-|1,4-alpha-glucan-branching-protein-GlgB
MSTPDASTALDLPAIDDGVLAAVGTGSYYDPHSVLGQHEVHAPGLSDPVTVIRTLRPLAEEVSAVLSTGARVQLTHLAHGIWQGFTLTGRDDYRIEARYADGGVWTADDPYRFAPSLGEVDLHLFGEGRHEKLWKVVGTHVRALSGVREEVAGTTFVVWAPHARAVRVIGDVNGWDGTLHAMRSLGSTGLWELFIPDLGEGGAYKFQILTQHGGWVERADPMARYTEVPPLTASKIGRARHEWQDEEWMATRAATDPHNSPMSVYEMHLGSWRPGLDYRTLADELIPYLTQLGYTHVEFLPLAEHPFGGSWGYQVTSYYAPTSRFGHPDDLRYLIDRLHQAGIGVLVDWVPAHFPKDEWALARFDGEALYEHPDPRRGEQPDWGTLVFDFGNSQVRNFLVANALYWLEEFHVDGLRVDAVASMLYLDYSRKEGEWLPNMYGGRENLEAISLLQEVNATAYKLHPGIVMIAEESTSWPGVTHPTNRGGLGFGLKWNMGWMHDTLDYIEHDPMYRQYHHGEITFSFLYAFSENFILPISHDEVVHGKGSLLSKMPGDHWQKLANLRAYLGFMWAHPGKQLLFMGQEFGQPSEWSEERGLDWWILDQPVHQALLGLVGQLNRVYRENPPLWRRDNEPGGFEWIDGGSSSQNLVSFLRWDDEGNPVAVLMNFSGQPVGPYRVALPVEGVWDELINTDAAEFGGSGVGNFGSVVAEPVPWQGRPFSAELTLPPLAALYLRPRPSPAAP
>NZ_CP020715.1|WP_085021381.1|1319687_1321676_-|alpha-1,4-glucan--maltose-1-phosphate-maltosyltransferase
MGRIPILDEQPVVDGGRWPAKAYAGEVLPFSATVFREGHDAVGAHLELESPAGVLTDVPLARVHSWDDRYRALAQVTSEGPWRFRIRAFSDDFATWEHNATIKIANGVDVELMFTIGAELFKRLSKEKGRPVPTKALFKTVSQTLSDKRLPVEERLAPIHSEEVASALTSRPAQSLVTYSEWHPLVVERARAGVGAWYELFPRSVGAEQAADGTWTSGTLRSAAERLPAVAAMGFDVVYLPPVHPIGSAFRKGRNNTLDPQPGDPGSPWAIGGAAGGHDAIHPDLGTQADFAEFVAAAAREGLEVAMDFALQASPDHPWVTEHPEWFTTLPDGSIAYAENPPKKYQDIYPINFDNDPEGIRQEALRILLHWIAFGVRIFRVDNPHTKPVDFWEWVIHEVNRRHPDVVFLAEAFTRPAMMQTLGKVGFQQSYSYFTWRNTKEELTEFFEMLGEWAPYYRANLFVNTPDILTEYLQFGGRPAYEIRAILAATASPSWGVYSGYELVENVARPGSEENIDNEKYEYKPRDFAAAEAAGTSLAPLITRLNAIRREHASLRDVRTIDVHWSDDDAVLVYSKHLDARFAPSGESDTVLVVVNTDPHSVRETTVHLDPTRFGLEADSEFTVRDLLTGQEFVWGQHDYVRLDSFTQPAHILHVQHERGDD
>NZ_CP020715.1|WP_085018997.1|1321885_1324447_+|alpha-glucan-family-phosphorylase
MRAIRRFTVRSVLPESLSALGELAVNLRWAWHEPTRQIFAHISPDVWTATEGDPVAVLGAAGTERLEGLAADPGFVAWANSLRDDLHAYLGGGRWYQQLEGPKPASIGYFSPEFGIAAALPQYSGGLGILAGDHLKAASDLGVPIIGVGLFYRSGYFNQAISREGWQLESYPILDPDGLPLSVLRQADGSPAQIVLALPDDRALYARIWQAQVGRVKLLLLDTDIPDNDDDLRSVTDRLYGGGGEHRLLQEMLLGIGGVRALNILAELTDTEPPEVFHTNEGHAGFQGLERISDLIGNGLTFDEALQVVRAGTVFTTHTPVPAGIDRFDRSLVERYFSTDMLPGLEVDRVLALGAEDYEGGSPDVFNMAVMGLRLAQRANGVSVLHGDVSRGMFNGLWPGFDKAEVPITSVTNGVHAPTWVDPALQELARERLGTQDTTAADWMSPAVGDGELWAVRGRMRRQLVLDARRRVTEAWRAQNPASIPPAWFNGLLDPDVLTIGFARRVPTYKRLTLMLHDPARLKAILLNPERPIQLVVAGKSHPADDEGKRLIQKLVQFASDPEVRHRIVFLPNYDIGMAQTLYPGTDVWLNNPLRPLEACGTSGMKAALNGGLNLSILDGWWNEYYDGDNGWAIPTADGAPDAEERDRLESEALYDLLEHQVAPRFYDRDADGIPANWMASIRHTLATLSPELSAERMVRQYVERLYAPATVAEEQMTSDDYEHARELSAWKERIRAGWPGVAVVHVESGGLDETPQVGEELHVRAQVQLGELSPDDVSVEVVYGHATSADELTETSTVALTPAGESAEGAARVYTGTVPLASSGTFGYTVRIVPRHAYLASEAELGLIAVAH
>NZ_CP020715.1|WP_085018998.1|1324459_1325026_-|TetR/AcrR-family-transcriptional-regulator
MSSVIEKRSRMSSDDRRDLVLAAATSVFAEAGYHGTTTDTVARAAGVSQPYVVRMFGTKENLFITVLTRALDLVMEAFRSALASRSPETSVETALGDSYYELAQDRDVLLCLMHAFTMGSHPVIGPCARDGFLSVFEFLRTDGGMSAAEAQEFLAGGMLINTVLGLRIPDNAGVNPCAAEVTDVVLGS
>NZ_CP020715.1|WP_157127424.1|1325067_1326555_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MRLLTTDHHRGKTLSTTEAATDVALEGRESTTTPTRRRVPVWLAIVAASVPMFMATLDNLVVTSALPVIGRSLEASIEQLEWIVNAYTLGFAGLMLFAVALGDRFGRRTVFLGGIGLFTVASALCAVATEPWMLIAARAVQGAGAAALMPLSLTLLVGSVSDRMRPLAIGIWGGISGLGVALGPLIGGAVIEGWSWDAIFWLNVPFGVLVIPLVLWALPNSFGARLRADVVGVLLAGIGVLGVVYGIVRGNEAGWTSLEVLGSMGLGAVLLAAFVVWESRVSNPLLPLRLFRDRSFSVANIVGFVFSFGAFGSVFILIQFLQIVQGASPLEAGVQTIPWTLAPVVVAPLTGLLAPRVGTRALIVAGLALQAIGIGWLALVMSADVAYTTLLPAFLFAGVGMSLVFAPSSTAVLANMSPADNAKASGTNSTLRELGVALGIAVLSAVFTGAGGSFTPTGYVDAAIPAVAVGAGALALAALLALLLPVGRERLAPAH
>NZ_CP020715.1|WP_085019000.1|1326656_1328717_-|glycogen-debranching-protein-GlgX
MIAADPLARLGVRQTSHGGEIRVWSENATSIELCLYDHKDPNWVFKTVPLTRGDGGVWSRRSRSLSPGRRYSLRVDGPEGPTHAFDPSLPLLDPYARAIARSGREQFRSVVVDEEFNWNGVGKPNTPLDHTVIYEGHVKGISRLNTRIPEHLRGSYAGLAHDTTIGYLKSLGVTAVELLPVHAFTSEQRLQKQGLVNYWGYNTLGFFAPHAAYASKQAQAEGPDAVLREFKGMVKLLHEAGLEVILDVVYNHTAEEGRLGPTTSLRGIDNASYYRQTSRGDYIDVTGCGNSVNTSVPAVSRMVLDSLRYWANEVQIDGFRFDLAATLGRNADHYYDHAHPLLEAIVHDPALADVKMIAEPWDVGMGGWQTGNFPDGWSEWNDRFRDRMRKFWLRDVKSIRENGSPGDGVGMLATRIAGSSNTFAQNRGPLASIDFVTAHDGFTLADLTAYNIKHNVGNGENNRDGSDDNMSYNHGIEGPTSSRTIEQTRRRAMRNLMGTLLLSAGVPMITAGDEFGRSQKGNNNAYCHDSELTWLSWDRRTWQKELWRTTQHLLRLRRENPALRPVRYGVFGERMPGASQMDWYDLHGESMSVAEWNAPENRTLQYVAASTPEHEEFNRILLVIHGVESPVEVTLPLHEGVEHYELLWDSAQEAPPQHHHDEVLPRYAPGSVIEVSPTSLQLFRAR
>NZ_CP020715.1|WP_085019001.1|1328784_1329969_+|cysteine-desulfurase
MPIYLDHAATTPLVPEAREAIVAALDLVGNPSSIHSQGQDARRVLEEAREAVAASLDADPVEVTFTSGGTESINLAVKGLHWRRQADAPRPVVLAATGEHHATADAVEWLERHEGAEVEWLPIDSSGVLSPSVLAEALARHEGRVSLVTFLWANNEVGTVQPVRALVEVAAAHDVPVHVDAVSAYGYVPVGLHASGAAAISVSAHKIGGPVGVGALLLARRWEVEPLIHGGAQQRARSGTQDVVGAAGFAAAARALAMPSHASFVEGLAALRDRLIAGLRAAVPDAVLRGPDPADGDRLPGNVHATFPGAEGDSLLFLLDMAGFSVSTGSACTAGVPETSHVLLAMGVPEDDARGALRFTLGHGTTAADVDALVAALPAAYASARAAGLAAGPR
>NZ_CP020715.1|WP_085019002.1|1330255_1331239_-|endonuclease/exonuclease/phosphatase-family-protein
MATLIDEPRQSMPTRAPRRRRSPRVGLAVTCVVLSLALALVLVAHRWIPDAGGLRLVIESGLPWLGLAIPVLLVFALLSHSKGAIAATVVPALVWAVVFIPAMLPLSWTGSPATASDTLTVASQNVEADSGTAAESATALAATGAQVIALQEMDDDARAEVDAVLDDRYAYSYGIGTVGLWSSYPIENAQMLDLGLGWQRGIAADLSTPVGLVSIYVIHAASARPDDHADRDTMLANLADYAQRDPNSRLIMMGDFNAGASDRNLSALTSQLSEPNQSGGGLGFTWPASLPLTRPDHVLARGMEATSNTTTRAGASDHLALITTFAL
>NZ_CP020715.1|WP_085019003.1|1331391_1332534_+|tRNA-2-thiouridine(34)-synthase-MnmA
MKVLAAMSGGVDSAVAAARAVDAGHDVVGVHLALSRMPGTLRTGSRGCCTIEDSMDAQRAANVIGIPYYVWDFSERFKEDVVDDFVSEYRAGRTPNPCMRCNERIKFAALLDKARSLGFDAVCTGHYASIVVDENGDRELHRAADWAKDQSYVLGVLTAEQLAHSMFPLGSTPSKAEVRAEAAARGLSVAAKPDSHDICFIPDGDTAGWLADRVGVEPGPIVDAAGEVVGAHEGAHRFTVGQRRGLNLGVPAPDGRPRFVLEVRPVSNEVVVGPREALAVAELAGSRYTWAGRPPADATTEFACQVQIRAHGDPVDATARLRPAAGEEGDELVITPAVPLDGVAPGQTAVVYVGTRVLGQCTIDRTVSAVPALVGGKAAR
>NZ_CP020715.1|WP_085019004.1|1332530_1334903_+|NAD-dependent-DNA-ligase-LigA
MSDATTTDALPEESAPDLAAAKAEADRLTTRILELRDEYYENDASTVTDAEYDAMVRRLGELERLHPELQSADSPTQTVGGRAETTLFAPVTHAERMLSLDNVFSEEELDEWAAKVERDAGRASVRYLSELKIDGLAINLRYEDGVLVTAATRGDGVVGEDVTQNVLQIESIPSRLQGTGHPPLVEVRGEIFFPVEAFEELNRGQIEAGERVFANPRNAASGSLRQKREGKNDRQLALMHARLSRLRMLVHGIGAWPDPPVAAQSEVYDLLKGWGLPTSTHYRVFDTIDEVAGFIRYYGEHRAAVEHQIDGIVVKVDDLALHAELGATSRAPRWATAYKYPPEEVNTKLLDIVVSVGRTGRATPFAVMEKVEVAGSEVRQATLHNQDVVKAKGVLIGDTVVLRKAGDVIPEVLGPVVELRDGTEREFVMPELCPECGTRLAPAKEGDIDLRCPNSRSCPAQVRGRVEHAGSRGALDIEGLGEVSAAALTQPIEPATPPLVTEAGLFSLTMSDLFPIRAVVRDNETGLEKLTESGDPKLVTPFRRRRTKKDPAFDEMAVPGSPEFWGDAQSVPSSAAVELLANIEAAKTKPLWRILVALSIRHVGPVAARALADWFGSLDAIRSATRDELAAVEGVGGIIADALIDWFTVDWHVEILDRWAAAGVQFATPGHPGPGASVGAGGVLEGLTVVATGSLEGYTREGAQEAIINAGGKAASSVSKKTDFVAAGPGAGSKLTKAEQLGLRILDAAEFHLLVTQGPDALAPAGDPADDAAGEAHEEAPAQEDDGPAE

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Crispr_ID: NZ_CP020715_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_5

1767685-1767781

Orphan

Consensus_repeat	Method
ATCGGAGCGGTGCGCGACATGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_5

>merge|NZ_CP020715|5|1767685-1767781|CRISPRCasFinder
ATCGGAGCGGTGCGCGACATGTCGAGGCTCCTCAGGGCGGGCTGAGCGAGCCGGTCGGCCCTGCGGCTCCGACCATCGGAGCGGTGCGCGACATGTC

>NZ_CP020715|5|5|1767685-1767781|CRISPRCasFinder
ATCGGAGCGGTGCGCGACATGTC	GAGGCTCCTCAGGGCGGGCTGAGCGAGCCGGTCGGCCCTGCGGCTCCGACC
ATCGGAGCGGTGCGCGACATGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085019358.1\|1769107_1770322_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238198
NZ_CP020715.1\|WP_085019360.1\|1771279_1772782_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|227937
NZ_CP020715.1\|WP_085019354.1\|1766002_1767067_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187566
NZ_CP020715.1\|WP_085021424.1\|1775196_1775790_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377129
NZ_CP020715.1\|WP_085019362.1\|1773995_1774502_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP020715.1\|WP_085019361.1\|1772727_1773972_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP020715.1\|WP_085019357.1\|1768673_1769111_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237522
NZ_CP020715.1\|WP_085019348.1\|1759539_1760508_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187549
NZ_CP020715.1\|WP_157127154.1\|1774642_1775200_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP020715.1\|WP_085019349.1\|1760655_1762005_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380464
NZ_CP020715.1\|WP_085019353.1\|1765022_1766006_+\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|378389
NZ_CP020715.1\|WP_115365076.1\|1757936_1758911_-\|permease	unknown	unknown	gnl\|CDD\|223773
NZ_CP020715.1\|WP_085019364.1\|1775786_1776086_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085019351.1\|1763009_1764230_+\|chromate-efflux-transporter	unknown	unknown	gnl\|CDD\|273350
NZ_CP020715.1\|WP_085019345.1\|1757173_1757944_-\|TIGR03943-family-protein	unknown	unknown	gnl\|CDD\|274870
NZ_CP020715.1\|WP_085019350.1\|1762054_1762834_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP020715.1\|WP_085019347.1\|1759102_1759408_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_157127153.1\|1767897_1768578_+\|DUF2064-domain-containing-protein	unknown	unknown	gnl\|CDD\|275102
NZ_CP020715.1\|WP_085019359.1\|1770473_1771145_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085019352.1\|1764423_1765026_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|182015

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085019358.1\|1769107_1770322_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|238198	cd00321, SO_family_Moco, Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Assimilatory NRs catalyze the reduction of nitrate to nitrite which is subsequently converted to NH4+ by nitrite reductase. Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.	5.96236e-27
NZ_CP020715.1\|WP_085019360.1\|1771279_1772782_+\|DUF2029-domain-containing-protein	gnl\|CDD\|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	0.000639869
NZ_CP020715.1\|WP_085019354.1\|1766002_1767067_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.83741e-69
NZ_CP020715.1\|WP_085021424.1\|1775196_1775790_+\|hypothetical-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	0.00881947
NZ_CP020715.1\|WP_085019362.1\|1773995_1774502_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	9.4996e-09
NZ_CP020715.1\|WP_085019361.1\|1772727_1773972_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	2.37582e-150
NZ_CP020715.1\|WP_085019357.1\|1768673_1769111_-\|hypothetical-protein	gnl\|CDD\|237522	PRK13822, PRK13822, conjugal transfer coupling protein TraG; Provisional.	0.00593875
NZ_CP020715.1\|WP_085019348.1\|1759539_1760508_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187549	cd05238, Gne_like_SDR_e, Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs. Nucleoside-diphosphate-sugar 4-epimerase has the characteristic active site tetrad and NAD-binding motif of the extended SDR, and is related to more specifically defined epimerases such as UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), which catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup includes Escherichia coli 055:H7 Gne, a UDP-GlcNAc 4-epimerase, essential for O55 antigen synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.65761e-88
NZ_CP020715.1\|WP_157127154.1\|1774642_1775200_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.67184e-32
NZ_CP020715.1\|WP_085019349.1\|1760655_1762005_-\|hypothetical-protein	gnl\|CDD\|380464	cd19542, CT_NRPS-like, Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs). Unlike bacterial NRPS, which typically have specialized terminal thioesterase (TE) domains to cyclize peptide products, many fungal NRPSs employ a terminal condensation-like (CT) domain to produce macrocyclic peptidyl products (e.g. cyclosporine and echinocandin). Domains in this subfamily (which includes both terminal and non-terminal domains) typically have a non-canonical conserved [SN]HxxxDx(14)Y motif at their active site compared to the standard Condensation (C) domain active site motif (HHxxxD). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.	5.65786e-10
NZ_CP020715.1\|WP_085019353.1\|1765022_1766006_+\|anti-sigma-factor	gnl\|CDD\|378389	pfam10099, RskA, Anti-sigma-K factor rskA. This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.	4.15016e-15
NZ_CP020715.1\|WP_115365076.1\|1757936_1758911_-\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	4.55559e-48
NZ_CP020715.1\|WP_085019351.1\|1763009_1764230_+\|chromate-efflux-transporter	gnl\|CDD\|273350	TIGR00937, Chromate_transport_protein, chromate transporter, chromate ion transporter (CHR) family. Members of this family probably act as chromate transporters, and are found in Pseudomonas aeruginosa, Alcaligenes eutrophus, Vibrio cholerae, Bacillus subtilis, Ochrobactrum tritici, cyanobacteria and archaea. The protein reduces chromate accumulation and is essential for chromate resistance. [Transport and binding proteins, Anions].	3.41564e-82
NZ_CP020715.1\|WP_085019345.1\|1757173_1757944_-\|TIGR03943-family-protein	gnl\|CDD\|274870	TIGR03943, TIGR03943, TIGR03943 family protein. Members of this occur in gene pairs with members of pfam03773. The N-terminal region contains several predicted transmembrane helix regions while the few invariant residues (G, CxxD, and W) occur in the C-terminal region.	9.05346e-43
NZ_CP020715.1\|WP_085019350.1\|1762054_1762834_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.30916e-17
NZ_CP020715.1\|WP_157127153.1\|1767897_1768578_+\|DUF2064-domain-containing-protein	gnl\|CDD\|275102	TIGR04282, hypothetical_protein, transferase 1, rSAM/selenodomain-associated. Members of this protein family show strongly correlated phylogenetic distribution, and in most cases co-clustering, with an unusual radical SAM enzyme (TIGR04167) whose C-terminal pfam12345 domain often contains a selenocysteine residue. Other members of the conserved gene neighborhood include another putative glycosyltransferase, an alkylhydroperoxidase family protein (TIGR04169), and a phosphoesterase family protein (TIGR04168). The cassette is likely to be biosynthetic but its exact function is unknown. [Unknown function, Enzymes of unknown specificity].	2.91304e-38
NZ_CP020715.1\|WP_085019352.1\|1764423_1765026_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|182015	PRK09646, PRK09646, ECF RNA polymerase sigma factor SigK.	4.98538e-90

>NZ_CP020715.1|WP_085019354.1|1766002_1767067_+|NAD-dependent-epimerase/dehydratase-family-protein
MTRLLVTGGAGFIGGEIVTAALDAGWDVRILDSLRPDVHGPALPAVDPRAELVVGSVTDPDDVAGALAGVDVVSHQAAKVGLGVDFSDAPDYAGSNVTGTAVVLAGMAEAGVRALVVASSMVVYGEGAYLGPRGLVRPPARAVADLDAGRFDPRDPETGIALVPTLVDESAPLDPRNVYATTKLAQEHLASSWARSVGGTVIALRYHNVYGPGMPQNTPYAGVASLFRSALERGEAPRVFEDGAQRRDFVHVRDVARANVAALDAVRHPSAAFRAYNVGSGHVHTVGEVAAALSAAAGGPEPVVTGDYRLGDVRHITASSQRIADDLGWAATEPFDDGMREFASAPLRSAVVAA
>NZ_CP020715.1|WP_085019353.1|1765022_1766006_+|anti-sigma-factor
MTGDGLRPGDDLDRSAAAAAHALDATDHEEAAAVERAADRSSVAREELDAFRETAGMLGLAAAPVEPSAALKSDLMAKIALTPQDRPVADREVAAAEDASRDPKPDSPAADAPSADAGLARLGLVDSVPLQADDPRLGGEPAAEPSGGIEDETTVSSRTGSPSQAERRAERRWFSRPALLLGGVAAAAALLVGGVAGAAITSSVTDTSAVTASAEQLAAITSAPDSKTARSTMEDGSTATVVWSDSMAQSAVLVDGLSALPSDRTYEAWYVGSDEVVPAGTFQAGDGTTWHVLDGSMTHGAAIAVTVEPAGGSDQPTSVPILVVESA
>NZ_CP020715.1|WP_085019352.1|1764423_1765026_+|sigma-70-family-RNA-polymerase-sigma-factor
MLRIVSSEEPPPGQTEDPVAVPLEDLMAGIAQGDQEAFSALYDRTASRVLGLVQRLLIDHAQSEEVTQEVFLEVWRTAPRFDATRGSTMSWLLTMGHRRAVDRIRSSQSSHDRDERIGIRDLESGYDVVAESAEIRIENERVKRALAQLTELQRQAIEMAYYGGLTHTEISATLSVPVGTVKTRLRDGMIRLRDAMGVTA
>NZ_CP020715.1|WP_085019351.1|1763009_1764230_+|chromate-efflux-transporter
MSSAVDDIPASRAGTPWEVFRVFLRLGVTSFGGPIAHLGYFRDEIVTRRRWLGDREYGDLVALCQFLPGPASSQVGFGLGLLRAGPFGALAAFLAFTLPSAILMVAFAYGAALFEGPVGAGILDGLKIVAVAIVAQAVWGMARTLTPDARRAGIAVVAAVLATALAGSLGQIGAIVVGAVAGLLLCRAAPAEADDLVRFPVARWAGVTCLVLFVVLLVGTPAVVALTGSGGLDLFDAFYRAGALVFGGGHVVLPLLQAGVVDTGWVSDGQFLAGYGAAQAVPGPLFTFSAYLGALSDVGPGGVAGAAIALVGVFLPGFLLLTGVLPFWNGFRRRTWAQALMRGANAAVVGILAAALYSPVFTTAIVGPAEFCLGLVCFVLLIAFRLPAWAVVLVGAAGGVVLAFLP
>NZ_CP020715.1|WP_085019350.1|1762054_1762834_+|alpha/beta-hydrolase
MPVLDVRGATIDYEIEGSEGPLVVQLHGLTSSRTRDALLGLDLGRSLRAHRILRYDARGHGRSTGSTSKGDYGWQALAGDLLALLDHIAPGERVHGVGPSMGTGTLLHAAVQDPERFATLTLVTPPTAWKRRKEQAAVYLRNADQVERLGTVALVESGSTAPVPPALADAPLTRPTVAEDLLPTVLRGAAKTDFPPKKAIKRIETPTLILAWTGDRTHPVKTANTLAELLPHSRMVLARTPYGVMAWPGLFAEHVTLHE
>NZ_CP020715.1|WP_085019349.1|1760655_1762005_-|hypothetical-protein
MRLTTVAQMSLSTGRLHSLRLRAVGDPVREVPVSFDQGRHVGAGDRPGSWMALAFRLPRPTTTAELEAAWLEVVARHGTLRTVFSRSDDGALRLHETEVASAGWSEHPVGAGEDARAVLRAVLDTECRPFAAPSHLVCLVEPGDGEADRRPMCVIASDHAHVDMWSLAVLGRDVLGLLDRTLPASGEAGAASGEAGAVRDDGPPFPAFAEHTAALEAMPPAPDEVRRDWAAALEDTGGVMPAFPLPLGTLAEPREAVVEIRDVLGPEELSRFEAAARARGVRALSLATASLASVTRRLADAPLRAVFPVHSRFEERWRHSVGWFITNSILECEDADPVACAADVARAITLGGYPLAPLLAPYGGMVEPRGMFALSWLDVRRLPVALPAELEAQYVSAVISTDAVMIWFIVNTSGMHLRCRYPDTEEARDSLGRWLDALETDLKEHACAS
>NZ_CP020715.1|WP_085019348.1|1759539_1760508_-|NAD-dependent-epimerase/dehydratase-family-protein
MRILITGGSGFLGTLLARRLLSSAVGVGGATPDAVSGLVLLDVVPPQPDLADDPRVTAVVGSLDDPDVLATIGESDAVVHLAGVVSGAAEADLDAGLRSNLDGLRALLDAVRTWRTPPVLVFSSSLAVFGRDPALAPLGVIADDTLPTPQSSYGIQKLIGEHLVTDYTRRGLVRGRSVRLMTVAVRPGRPNAAASSFLSGIIREPLAGVRAACPVDPDMPVALSSPSATLSGILRALEVTDAEWGSTTAMSLPALTTTPREMVAALGRIAGPEVASLVDWIPDPAIEAIVGTWPSRFSTPRAASLGLSPVPSFDDVITEFLS
>NZ_CP020715.1|WP_085019347.1|1759102_1759408_+|hypothetical-protein
MTMSDGPMPAPERRRPRLNPFSIALAAVAISGIVGGMLLEFAASTASTDWTLGYADSAAYAAAAWTRSSATWSKLLLVSGVVGFVGCLVVEGVAWDARRRR
>NZ_CP020715.1|WP_115365076.1|1757936_1758911_-|permease
MLGLGVGVAALAALIAIRTVTAGWDDLSLPEALRDFVTLSTSVIIESLPFVFLGVLLSVVVQIWVPDRVIHRILPRNRTARRAVLSLLGVLLPVCECGNVPLARGLVIKGVGVPEAATFLLAAPILNPVTIVTTYQAFGWNDGILAGRIVGGFVIANLVGWLFSRHPEPERLLTPEFSASCRVHRDHPVSGRRMRRAVAGFAEETATMLPALVIGSLIAGAIQVGVSRDVLGALGANPIWSVLALMALAFIVAICSNVDAFFILAFGATFTPGSIVAFLVFGAMVDVKMIAMMRTTFTTRALVVLVSVVALTTLVLGFGVNLLV
>NZ_CP020715.1|WP_085019345.1|1757173_1757944_-|TIGR03943-family-protein
MSRLLDRWRGVVISLLGVAAILWLAVDGSLGLYIHPRYFVFTVVMAVIAGVAVIAAFALVPARGDADDEHGHDHEHDHGTGGRSPVRRGLTAAGTLVAVAVAAVVLVVFPPSTLSTTSASTAQLDNATTVSAPSTELLTGTDTATFSVKDWASVLRQGGDFADGRTADLTGFVMASPDSPDLLYVARYVITCCAVDAQPAGVPVYSPGWQDTVQEGAWVHVTGAFSPNPVSASTAAYTLTPTVLEPIDEPSDPYDY
>NZ_CP020715.1|WP_157127153.1|1767897_1768578_+|DUF2064-domain-containing-protein
MTHAGVIEEVAVVAAVVIAKECVPGRVKTRLNPPLSLEQAAEVAAASLADTVDVITSLPFTRRILAYAGENAPVSADWEVLPQTSGTLDLRLGDVFDAVGEPMVLIGMDTPQVSARHLVPLLRGWPDDADSVFGPALDGGFWALGMREPDGDLIRGVPMSQDFTGRAQLARLRTAGHRVRMLPELDDVDTVDDALRIAAEAPRTRFAAALRGALGEIGAVEIPVTA
>NZ_CP020715.1|WP_085019357.1|1768673_1769111_-|hypothetical-protein
MRWARRILIAAGAAVIALGAVVLAAEQTVPQIVGVGAWLLAAIVLHDGVLAPVVFGLDLLLRRTGRRIRPVYLVVAQVAVVVGAVLTLVIVPEIRATTIGNPNPTVVPFDYAARLAWMWVALAAVTALVCLAIAMSTRIASRRRP
>NZ_CP020715.1|WP_085019358.1|1769107_1770322_-|molybdopterin-dependent-oxidoreductase
MRELLHRTRIALTTPSRTPRMAVVIGRLLGAAFLICFATGLYSHFLQEPLPGMRFSPSPSWLYQVTQGIHVTAGIACVPLILGKLYAVYPQLFQTPLVRGPLHLLERASIALFVGASLVEVAIGLVNTFQWYPWPFGFREVHFALAFVVIGSLAVHIGVKLPVIARYWTRRRAESADDVEQPTAPARGLTGRVFRWIDETPRRSPEVSRRGFLTAVGASVVGVVALTAGQSFRVLDPVNVFAPRKQGYGPQSLPVNRTAEQAQVSASALDPGWALVVTAGATTRAFSRAELLALPQTTAELPIACVEGWSQTATWTGVPVRVLLDEVGAGPDAPVTVTSLETEGAYRQTRMGGEYSSDPSTLVALRLGGADLDLQHGYPARIIAPGRPGVLQTKWLSRIEVDPA
>NZ_CP020715.1|WP_085019359.1|1770473_1771145_+|hypothetical-protein
MRTFTKAVIGAAAAGALAFSLAACSGSSSSDTGSASSPSASSTPTPVASIPELTGKMTQVTVDKGFLDALTSLGLTPGVVGTATLTDGVLSFPITGGNVDYYDPNQPYRPYVQGEIDHEGSGLSLSAGGTTVELTNFTIDPGTSKLYGDVSANGSPVVQQAFLFDLDGSTLKPLQTSGDTAILEGTTVHVSADAAALLNKTFNTDAVKEGLLVGVAKITVNTK
>NZ_CP020715.1|WP_085019360.1|1771279_1772782_+|DUF2029-domain-containing-protein
MTEPSRDPRRRRSMAALAALAALVGALAVAVVIGVMASRMQLFDGSQAPAFVVMTLLAWLLFGVSMALLGRVPDRAVPAVVLLGAVLVGGAALAGPPNTSTDSARYSWDGILQNEGLSPYADVPAADALAPYRTDWLFPTTRVFENGTLECAGLRIDGTRTVPDDQPLCTAINRPQVPTIYPPSAELYFAGVRAVVPVDAEYWPFQVGGLLVSLSVTTMLLLALRRRGAGDRWRSARWAAAWGWCPFVATEAVTNSHVDVLGAALALAGSLVVVSAARRRTRRDRGDAAARESRGGRRLRLVAGGVLLGAAVATKLVPAIVMPPLLRVRGAWLVVAASLATFAALYVPFVAQSGPGVLGYLPGYLGEEGYQDGSAFALLSLVLPGPVAVLPAAAILAVTAVLCIRHADPTAPWVAQTVFIGTTLLVVSPRYGWYALLLIPFVVLSRRWEWFVVPLALSLDMIAQSVLFTRLSLLVAVLVVLAGWSMRRALPDAFRPLSTS
>NZ_CP020715.1|WP_085019361.1|1772727_1773972_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MVDAQSAPRRIPPVVNLLRRIPLAAWTGIHTDHVRPDARWKARVLPNDETVRFLSVDGAYEPSEAAQPFAAYLDDLTTDDLVGFYREMVVVRRMDQEGHNLQRQGQLGLWVPSQGQEAAQIGSAHAARRQDHLFPSYREHAVAYARGVDLIGVVALLRGLTHGGWDATDPTNGNVHNYTLVIGSHALHATGYAMGVALDGMVGTGTEDDTAVLCYFGDGATSQGDVSEAFVFSASSQAPVVFFVQNNQWAISVPVTTQSRVPLVERPRGFGIPSTQIDGNDVLASYAATRMHLDAARAGEGPRMIEALTYRLGAHTSSDDPTKYQAPELLAEWQAKDPVPRLRRYLESLGVDGATFESIDVEAEDHAADIRRRTHELPVPEASALFDHVYSEPHPVMVEQKDWLARYESSYGAA
>NZ_CP020715.1|WP_085019362.1|1773995_1774502_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MRAPREGDDSPGRSGRWATTEVDPQTLRGLSILYSPRTDGRADPGEVVWTWVPYEEHDGRGKDRPVLVVASLPDSSLVGVQLTSKPHDDRWTIGIGPGAWDSSGRPSWVRLDRVFLLHQAGLRRAGVALDAARFRAVSAELARRHGWPAVRPRRRGLRGLLSRLLGRA
>NZ_CP020715.1|WP_157127154.1|1774642_1775200_+|sigma-70-family-RNA-polymerase-sigma-factor
MTRHPLDDAPDALLVARAGDGDVSAFEVIVRRYSRRLRAYASRMMGSSLESDDAVQDALIAAWDRIDTLEDGSVLRSWLMRIVTTKCLDRIRRRKDHLVLEESWTVSAPSVDLPERRAEAAAALGDLDAALSRLPDLQRQTWIMREWGGASYDEIGNALGIAPSTVRGLLARSRRTLMTDMEGWR
>NZ_CP020715.1|WP_085021424.1|1775196_1775790_+|hypothetical-protein
MTDDQRDLFDEDRLDGHTVEELSDYLDAGRQPADPSIDDSAGCQIALSALERLRATSLSALDAAESATPHDEGWIRGVMADIALDAHAGRDIPIPYPDPTVRLAITEGAVRELVRSVGDAQDGLLVGRVRLQGDVETLGAPVGLQITVTVAYGFEIPVVVAALRAAVRAALLHHVVLDVDDIEVTVTDIHGLPEELR
>NZ_CP020715.1|WP_085019364.1|1775786_1776086_+|hypothetical-protein
MNDSILSEALTGRLSEVEGVSRLYRTGALGGLQAIVTRGEPTASVSTSEDSTVVVANLGVTTARPACATLVEAADAVVAQLRSDGVVERDVTLRVCRIL

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Crispr_ID: NZ_CP020715_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_6

2177342-2177422

Orphan

Consensus_repeat	Method
GAACGGGTTGTTGCCGGGACGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_6

>merge|NZ_CP020715|6|2177342-2177422|CRISPRCasFinder
GAACGGGTTGTTGCCGGGACGCGGAGCGCCGGGACGCTGCATGCCCTGCTGGCTCGCGAACGGGTTGTTGCCCGGACGCGG

>NZ_CP020715|6|6|2177342-2177422|CRISPRCasFinder
GAACGGGTTGTTGCCGGGACGCGG	AGCGCCGGGACGCTGCATGCCCTGCTGGCTCGC
GAACGGGTTGTTGCCCGGACGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085019709.1\|2171706_2172075_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085019715.1\|2179423_2181187_-\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP020715.1\|WP_174604443.1\|2181300_2181831_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NZ_CP020715.1\|WP_157127449.1\|2171196_2171571_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085021448.1\|2173823_2174621_+\|adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP020715.1\|WP_085019714.1\|2178342_2179338_-\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NZ_CP020715.1\|WP_085019722.1\|2186301_2187939_-\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|236448
NZ_CP020715.1\|WP_157127451.1\|2172076_2173825_-\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NZ_CP020715.1\|WP_085019707.1\|2170270_2171200_-\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NZ_CP020715.1\|WP_085019713.1\|2178006_2178276_-\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|377288
NZ_CP020715.1\|WP_085019720.1\|2183917_2185381_-\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|236447
NZ_CP020715.1\|WP_085019704.1\|2166875_2167454_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238866
NZ_CP020715.1\|WP_085019719.1\|2183648_2183915_-\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|184055
NZ_CP020715.1\|WP_085019718.1\|2182836_2183577_-\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_CP020715.1\|WP_085019705.1\|2167450_2169004_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187556
NZ_CP020715.1\|WP_085019717.1\|2181838_2182462_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|234860
NZ_CP020715.1\|WP_085019711.1\|2174590_2175037_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NZ_CP020715.1\|WP_085019706.1\|2169045_2170260_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NZ_CP020715.1\|WP_085019721.1\|2185398_2186298_-\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|235535
NZ_CP020715.1\|WP_085019703.1\|2165528_2166863_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|236208

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085019715.1\|2179423_2181187_-\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP020715.1\|WP_174604443.1\|2181300_2181831_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	3.14184e-28
NZ_CP020715.1\|WP_085021448.1\|2173823_2174621_+\|adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	3.91986e-70
NZ_CP020715.1\|WP_085019714.1\|2178342_2179338_-\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	5.4747e-173
NZ_CP020715.1\|WP_085019722.1\|2186301_2187939_-\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|236448	PRK09281, PRK09281, F0F1 ATP synthase subunit alpha; Validated.	0
NZ_CP020715.1\|WP_157127451.1\|2172076_2173825_-\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	1.54688e-114
NZ_CP020715.1\|WP_085019707.1\|2170270_2171200_-\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	1.86133e-122
NZ_CP020715.1\|WP_085019713.1\|2178006_2178276_-\|YlxR-family-protein	gnl\|CDD\|377288	pfam04296, DUF448, Protein of unknown function (DUF448).	1.36984e-23
NZ_CP020715.1\|WP_085019720.1\|2183917_2185381_-\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|236447	PRK09280, PRK09280, F0F1 ATP synthase subunit beta; Validated.	0
NZ_CP020715.1\|WP_085019704.1\|2166875_2167454_-\|hypothetical-protein	gnl\|CDD\|238866	cd01828, sialate_O-acetylesterase_like2, sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	7.84391e-66
NZ_CP020715.1\|WP_085019719.1\|2183648_2183915_-\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|184055	PRK13442, atpC, F0F1 ATP synthase subunit epsilon; Provisional.	4.19565e-31
NZ_CP020715.1\|WP_085019718.1\|2182836_2183577_-\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	8.2695e-58
NZ_CP020715.1\|WP_085019705.1\|2167450_2169004_-\|SDR-family-oxidoreductase	gnl\|CDD\|187556	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2. This subgroup contains atypical SDRs, one member is identified as Escherichia coli protein ybjT, function unknown. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that generally matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.66204e-125
NZ_CP020715.1\|WP_085019717.1\|2181838_2182462_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|234860	PRK00901, PRK00901, methylated-DNA--protein-cysteine methyltransferase; Provisional.	1.32268e-42
NZ_CP020715.1\|WP_085019711.1\|2174590_2175037_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.99101e-45
NZ_CP020715.1\|WP_085019706.1\|2169045_2170260_-\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.75624e-96
NZ_CP020715.1\|WP_085019721.1\|2185398_2186298_-\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|235535	PRK05621, PRK05621, F0F1 ATP synthase subunit gamma; Validated.	2.87743e-127
NZ_CP020715.1\|WP_085019703.1\|2165528_2166863_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|236208	PRK08262, PRK08262, M20 family peptidase.	1.39748e-162

>NZ_CP020715.1|WP_085019711.1|2174590_2175037_-|30S-ribosome-binding-factor-RbfA
MVDQARARKMADRIKEIVAKRLDRGLRDPRLGFVTITDVRVTGDLQHASIFYTVYGTDQERADSAAALKAATGMLRTEVGRNITARLTPSLEFIADAIPENAQHIEGLLAEAHARDAEVESLAKSASYAGEEDPYVKPRQADEDDDED
>NZ_CP020715.1|WP_085021448.1|2173823_2174621_+|adenine-glycosylase
MLQQTPVVRVVPRLAEWLERWPEPRDLAADAPGEAVRMWRSLGYPRRALRLHACAVAIVERFDGRVPDDVEDLLSLPGIGDYTARAVAVFAYGRRAPVVDTNVRRVIARAVEGAPDAAAPSARRDLAAMDALLPADVVDSTRFNAGMMELGALTCTARSPRCETCPVATVCAWRRRGYPEDEVARRPVQKRYEGSDRQARGILLAAVRDADAPVGEAALRLALPDVARFGRALDGLLTDGLLEQAPDGRFQLPGLAQSSSSSSSA
>NZ_CP020715.1|WP_157127451.1|2172076_2173825_-|tRNA-pseudouridine(55)-synthase-TruB
MISETRVPHGLKPGRRQGRSRASRANHSITASWRSVRALGTRPLYASPLVHWIHGARDHSRLAAGRRARRRDHPQLRSRTHRCRGRRDRGHPADRRRAGPCLPARRAPGGPREPRRLPDARRARAGHGRGGVLRSLRRPDASAGAARALQAGGQHRLPAPGVRRRARHRRGVGLDHRRPRRLPGARWAVPAASRPARAVQRDRLRRDALGGRARGAPGRGRALPGGGGTALRRHGDRRRGRSGASASCLRRQLLTAGAPPTGADDARPSAVSVARVIAPPAPQSGILLVDKPQGITSHDVVARARRALGTRKVGHAGTLDPMATGLLVLGVGASTRLLTYVVGLGKEYRATVRLGASTVSDDADGEVVAWAPSRTVSDAAIDAAFAGQVGDVQQVPSAVSAIKVDGRRAYARVRAGEDVELAPRSVTIESITRTAEPRRLVVDGHDVIDVDIVVRCSSGTYIRAIARDAGTSLGVGGHLTALRRTAIGPFAVTEAVDGASLPDERPELLGAAATAERLFPVVRLDAVGAVALSQGKRIPVEHSDTAGPVAAIAEDGRLIGLVRVDRGIARTLVNFPTDGAEG
>NZ_CP020715.1|WP_085019709.1|2171706_2172075_-|hypothetical-protein
MVVWFSIAQVLIAVAAGILCVVLGLLRRVPSDLTMGALALVELLLIVQLVVTFIAPAVGNPPSGDPLEFYVYLVSAILLPIAGGFWALVERSRWSTVVIGAVCLAIAVMVWRMNQIWLVQGV
>NZ_CP020715.1|WP_157127449.1|2171196_2171571_-|hypothetical-protein
MGLVLVVVYGILALAATGRSFVQIVREFDDAPVAYSLSALAAVVYIVATIALIAPGRVWYRVAWITISFELVGVLTVGTLSLTHPELFAHASVWSWFGMGYLFVPLVLPVLGMLWLYRTRRSQA
>NZ_CP020715.1|WP_085019707.1|2170270_2171200_-|bifunctional-riboflavin-kinase/FAD-synthetase
MKVFRSLEEVPSGFGPSAVTIGKFDGLHRGHRAVIDELVGVARRRGLTSVVVTFDRHPLAHLDPAARPAPLVSNAQRLDLIAEAGVEATLLLPFDATLAAMSPEEFAARVLRDVCGAQFVMVGEDFRFGAKGAGSIDTLRSLAPALGFEVDVVADVRPEGDRKVSSTWIRELLAEGDVEGATELLGRAPSVRGVVVHGAARGRELGYPTANLSPDCEGLIPDDGVYAGTLTDGDRVYPAAISVGSNPTFEGVPPKQVEAYVLDRELDLYDHLVEVAFLHRVRGQVRFTGVEPLIAQMDDDVRRIREMLS
>NZ_CP020715.1|WP_085019706.1|2169045_2170260_-|MFS-transporter
MSETARRRAGGVLALVGIVVLALNLRTSVAALSPVVDEVGADIPLSAAGLGILGMLPPLCFAAFGLLTPPLQRRLGIEALLVVALAAIGLGDVVRGLATSYPVLLLGSVITFAGMGVANVLLPPLTKKYFPERIGLMTSVYATALAIGATVPPLVAVPVADAAGWRFELSIWGVLAVATMIPWILLLVREGRRARATDPEADVPERAWNGRVHRSVVAWSLLAMFAATGFNAYAMFAWMPEVLTDVAGVTDQQAGALLSLFAVMGLPAALLVPVLAARMRSVLPLILTGSGFYVAGYLGLLLAPSSAIWLWVALIGLGPLLFPLSLALISLRTRTHEGAVALSAFVQGGGYALSALGPLLVGVLHEATGAWTVPLVVLGAVGASSAIVGVVVSRPVLLEDERRR
>NZ_CP020715.1|WP_085019705.1|2167450_2169004_-|SDR-family-oxidoreductase
MTTRRALVTGASGYVGGRLVPRLLEAGFTVRVLVRNPQKLRDVPWADEVEVAVGDLGDRDAVAQAVADVDVLYYLVHSMGSGGDFEQAEEDAARGVAEAAESAGVGRIVYLGGLHPDGEELSPHLRSRTRVGEVLLASGVPTAALQAGVIIGSGSTSFEMIRHLTEVLPYMPAPRWVRNRIQPIAIRDVLYYLVAAADLPPEVNRTFDIGGPDVLRYGQMMNGYALEAGLHQRPIASLPVFTPWLASQWVNLVTPIPRSLAVPIIASLQYECVAREHDIARWIPDPEEGLSPYRLAVRRALQKTRDGEVETSWQDSDVQGAPADPLPSDPDWAGHTVYTDVKDRTTDASPEAVWTVVEGIGGENGWYSFPLAWALRGWMDKVVGGVGLRRGRRDPRRLAIGDALDFWRVEEIDRPRSLRLRAEMRVPGRAWLEMSVEPTGTGSRYHQRAVFFPKGLGGRLYWFAILPFHGIIFNGMANRITESALAADRETAALHRGDEPERMESTPTGPARRGGTR
>NZ_CP020715.1|WP_085019704.1|2166875_2167454_-|hypothetical-protein
MTEKPTIVFAGDSLTEGGRWQEWFPDVEAVNLGRGGDTTEGLIERLDEVTALDPDTVVLLIGTNDVANRRAVEQVVRNIETILVMLRQALPDARILVQSVLPRGAEYAEFLREINRHVWQFAATVKAHYLDLWPVMALEDGSLNDAYTDDGLHLNEAGYEAWLTELVPGVERVRDLPPSSRPIRLPELGELS
>NZ_CP020715.1|WP_085019703.1|2165528_2166863_+|M20/M25/M40-family-metallo-hydrolase
MTAPDDAVGRLRELLRIPTVSRPDVSDLDTDAFASFRSTVQALYPALHAAAERELVLEHTLLYRWPGAAEGPATVLMAHYDVVAAPDEGWTHPPFAAELVGDGAQQELWGRGALDDKDSVAAILEGAEALAETGFVPAHDVYLLFGHDEETNGTGAREAARLLEARGVRIGLVLDEGGAVVDGVFPTVDRPLAVVGVSEKTTTMIELRVEQQGGHASTPPRETATSRLARAIVRMNAHPFPATLNPPIERMLRTIAPHARGIVRFVLSRPRLFRPLLLQLLTRIGVETSALLRTTAVATMLSAGHAQNALAESATAVVNARVAIDSDTARTVRRLKRVIADDGVTIRVLQAARPSAVSAMDGPGWDLVAETITAVYPDAVVVPYVQTGATDSRQFSHLSPTVYRFSPFHMTAEERAALHAKDERIHVGAYLTGIAFFERLIARL
>NZ_CP020715.1|WP_085019713.1|2178006_2178276_-|YlxR-family-protein
MEAVRTCVGCRARAPRSSLVRFVARDLVLILDETATLPGRGAWLHPSLDCFHTAIQRRAFGRALRVQGQLESTNAETKLNGRVSTMSDD
>NZ_CP020715.1|WP_085019714.1|2178342_2179338_-|transcription-termination/antitermination-protein-NusA
MDIDLSVLRLLEREREIPFEELVSIIEQAILTAYLKHTDRPTTVNGVAAGRVHLDRKTGHISIFVPEFDEDEVLIGEAEENPSDFGRIAAFAAKQVINQRLRDIADDHVLGEFKGREGDIVAGIVQQGPNPRMVHVDLGSIEAILPPEEQVPGEEYAHGSRLRVYVTSVTRGTKGPSITVSRTHPSLVRKLFALEVPEIASGVVEIVSLAREAGHRTKMAVRAKEPGVNAKGACIGELGQRVRAVTAELGNEKIDIVDYSDDLATFVANALSPAKVSSSFVIDASTKAVRALVPDYQLSLAIGKEGQNARLAAKLTGAKIDIQPDSILDGD
>NZ_CP020715.1|WP_085019715.1|2179423_2181187_-|proline--tRNA-ligase
MSTRLSSYFLRTLREDPSDAEVASHRLLVRAGYIRRQAPGIFAWLPLGLRVKARIEAIIREEMAAAGAFEVHFPALLPKEPYEVTGRYEEYGPGMFRLSDRKDAGYVLAPTHEEVFTLLVKDLYSSYKDLPLTIFQIQDKYRDEARPRAGLLRGREFTMKDAYSFDSSDEGLDASYQAQRDAYERIFTRLGLEYVIVQADAGAMGGSKSEEFLHPTPVGEDTFVRSPGGYAANVEAFTTVAPEPRSFEHLTPAEVLDTPDTPTIQTLVDRANEAHPRPDGRAWTAADTLKNVVLALVHLDGRRELVVVGLPGDREVDMKRAEVAFAPAEVEPATEEDFAKHPGLVKGYIGPWSAAGPVLGEESSTGIRYLTDPRVVSGSGWITGANEHGRHVFGLVAGRDFTSDGTVEVAEVKAGDPAPDGSGPVELARGMEIGHVFQLGRKYADALGLKVLDENGKLVTVTMGSYGIGVTRILAIIAELNNDDKGLIWPKTVAPFDVHVIATGKEESIWTAAEDVVAQLEAAGLDVLFDDRPKVSPGVKFGDAELIGVPTIVIVGRGVADGVVELWDRATGERTSIPLDQVAAAIG
>NZ_CP020715.1|WP_174604443.1|2181300_2181831_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MQTRQIPPRTSRFDTPFGPLLVRAHDGVVHALRPWRVGDAADDDGSNRPIHDVLDAYLSGDARTLALPCEATGTPFQCSVWSAVTEIGWGELTTYAALAELIGRPGSARAVGQAVAAHPAPLVLGTHRVVASDGRLTGVDADAIVWKTALLRLEGHVVHEGRLIGAEAAGFVRVAA
>NZ_CP020715.1|WP_085019717.1|2181838_2182462_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MSTAELPPFPEFPSADLGRVASGAARTRPPRAPEVRHRGVLESPLGRVEVVSNGRAITGVAIETAGRLPHDGHPVSRSDLIDEAVAQIEAYFAGTRRRFELPVRPAVSDFQRSVLDALADVEWGRHTTYGALAEAIGRPAACRAVGRAIGQNPVPLLVPCHRVLSSTGSLTGYSQGDGDVTKAWLLDGEGIAFRWPPTRRRPAPVSL
>NZ_CP020715.1|WP_085019718.1|2182836_2183577_-|peroxide-stress-protein-YaaA
MLIVLPPSETKVDGGEGAPLDLALLSFPRLTRPRRSLVAAVRRLARRPEEMAAALKLGPRLAFEIDRNRALATSPTMPALGRYTGVLYDALDAASLPSAALDFAAGHLAIHSALFGLVGAADPIPAYRLSHDSKLEPTIKSVWGSTIARELGERPGLVLDLRSEGYVALGTASGNADAHYLHVVSEGPDGVKRALNHFNKKGKGEFARALLTQGEDFASIPALLDWATATGFRLTSRPDGSLELVV
>NZ_CP020715.1|WP_085019719.1|2183648_2183915_-|F0F1-ATP-synthase-subunit-epsilon
MANPLAVTVVAADREIWKGEASMVVAKTVEGEIGILAGHEPMLAILASGEVRVNASSGERIVARADDGFLSVENDTVTVVARDAELIR
>NZ_CP020715.1|WP_085019720.1|2183917_2185381_-|F0F1-ATP-synthase-subunit-beta
MTDTAIAPAATAGSGGAAGRIARVTGPVVDIEFPHDSIPEVYNALKTTITIGENSTEITLEVAQHLGDDLVRAIALKPTDGLVRGQEVRDTGAPISVPVGDVTKGKVFNVTGEILNAEPGETVEITERWPIHRKPPAFDQLESKTQLFETGIKVIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIQRVAQDHGGVSVFAGVGERTREGNDLIHEMEEAGVFDKTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQNQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGLLQERITSTRGHSITSLQAIYVPADDYTDPAPATTFAHLDATTELSREIASKGLYPAVDPLTSTSRILDPRYLGADHYRVATAVKQILQKNKELQEIIAILGVDELSEEDKITVARARRIQQFLSQNTYMAKKFTGVEGSTVPLKDTIESFDAIVRGDFDNVAEQAFFNVGPITDVEEKWAKIQKENG
>NZ_CP020715.1|WP_085019721.1|2185398_2186298_-|F0F1-ATP-synthase-subunit-gamma
MGAQLRVYRQRIRSAQTTKKITKAMELIAASRIQKAQARVAASSPYSRAVTRAVSAVATYSNVEHVLTTEPERIERSAILILSSDRGLAGAFNSQVLREAEELAELLRSQGKEVVYYLVGRKAAGYFTFRRRASEQQWVGETDVPEFDLAKSIGDRLLEDFLKPASEGGVDEIHIVYNRFVSMLTQTPEVVRLLPLEVVEGAEEPTAQVLPLYEFEPDVGTVLDALLPVYIESRIFNALLQSAAAKQAATQKAMKAASDNADTLILNYTRLANNARQSEITQQISEIVGGADALSHTKK
>NZ_CP020715.1|WP_085019722.1|2186301_2187939_-|F0F1-ATP-synthase-subunit-alpha
MAELTIRPDEIRDALKDFVAAYEPSKASTTEVGYVIDAADGIAHVEGLPGVMANELIRFSDGTLGLAQNLDEDEIGVIVLGEFSGIEEGQEVTRTGEVLSVPVGDGYLGRVVDPLGNPIDGLGEIATEGRRELELQAPGVMQRKSVHEPLQTGIKAIDAMIPVGRGQRQLIIGDRQTGKTAIAIDTIINQKANWESGDVDKQVRCIYVAIGQKGSTIASVKGALEDAGAMEYTTIVASPASDPAGFKYLAPYTGSAIGQHWMYGGKHVLIIFDDLSKQAEAYRAVSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELGHGSMTGLPIIETKANDVSAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGDAQVKSIKKVSGTLKLELAQYRSLEAFAMFASDLDAASRRQLARGARLTELLKQPQYSPFPVEQQVVSIWAGTNGKLDEVPVEDILRFEAELLDYLGRNTEILTTLRDTNVLDDDTVAALEKAVDDFKLEFQTGEGKPLASVGKEQFEATDPEDVNQEKIVKGRR

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Crispr_ID: NZ_CP020715_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_7

3001463-3001629

Orphan

Consensus_repeat	Method
AGCCCACGGATCTGACACTCGTGACGACTCCCGGCCCATGAACCCACCACAACTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_7

>merge|NZ_CP020715|7|3001463-3001629|CRISPRCasFinder
AGCCCACGGATCTGACACTCGTGACGACTCCCGGCCCATGAACCCACCACAACTGCCAAAGCCACGAAGGCGGGCCAGCCGATCACCTCACGACGCGCTCCCCCACCAGCTAAGCCCACGGATCTGACACTCGTGACGACCTCCCGGCCCATGAACCCACCACAACT

>NZ_CP020715|7|7|3001463-3001629|CRISPRCasFinder
AGCCCACGGATCTGACACTCGTGACGACTCCCGGCCCATGAACCCACCACAACTG	CCAAAGCCACGAAGGCGGGCCAGCCGATCACCTCACGACGCGCTCCCCCACCAGCTA
AGCCCACGGATCTGACACTCGTGACGACCTCCCGGCCCATGAACCCACCACAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_174604581.1\|2993451_2994885_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP020715.1\|WP_085020351.1\|2997432_2998395_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NZ_CP020715.1\|WP_085020350.1\|2996507_2997227_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085020359.1\|3005859_3006894_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP020715.1\|WP_085020353.1\|2999507_3000893_+\|L-serine-ammonia-lyase	unknown	unknown	gnl\|CDD\|273233
NZ_CP020715.1\|WP_157127243.1\|3008864_3011045_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP020715.1\|WP_085020360.1\|3006890_3007523_+\|NAAT-family-transporter	unknown	unknown	gnl\|CDD\|236850
NZ_CP020715.1\|WP_085020361.1\|3007612_3008812_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NZ_CP020715.1\|WP_085020352.1\|2998670_2999207_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223532
NZ_CP020715.1\|WP_174604480.1\|3011875_3012658_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP020715.1\|WP_085020347.1\|2991948_2992338_-\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_CP020715.1\|WP_085020354.1\|3001924_3002830_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380141
NZ_CP020715.1\|WP_085021534.1\|2995782_2996424_-\|YqaJ-viral-recombinase-family-protein	unknown	unknown	gnl\|CDD\|378216
NZ_CP020715.1\|WP_085020358.1\|3005332_3005611_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NZ_CP020715.1\|WP_085020356.1\|3003722_3004154_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_CP020715.1\|WP_085020355.1\|3003019_3003709_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_CP020715.1\|WP_085020357.1\|3004427_3005375_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP020715.1\|WP_174604479.1\|2993203_2993368_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378333
NZ_CP020715.1\|WP_085020348.1\|2992379_2992895_-\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_CP020715.1\|WP_085020349.1\|2994938_2995706_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_174604581.1\|2993451_2994885_-\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.69941e-56
NZ_CP020715.1\|WP_085020351.1\|2997432_2998395_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.60772e-105
NZ_CP020715.1\|WP_085020359.1\|3005859_3006894_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	6.40396e-41
NZ_CP020715.1\|WP_085020353.1\|2999507_3000893_+\|L-serine-ammonia-lyase	gnl\|CDD\|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP020715.1\|WP_157127243.1\|3008864_3011045_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000376041
NZ_CP020715.1\|WP_085020360.1\|3006890_3007523_+\|NAAT-family-transporter	gnl\|CDD\|236850	PRK11111, PRK11111, YchE family NAAT transporter.	8.89884e-42
NZ_CP020715.1\|WP_085020361.1\|3007612_3008812_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NZ_CP020715.1\|WP_085020352.1\|2998670_2999207_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	1.0249e-10
NZ_CP020715.1\|WP_174604480.1\|3011875_3012658_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.7558e-22
NZ_CP020715.1\|WP_085020347.1\|2991948_2992338_-\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	7.76679e-43
NZ_CP020715.1\|WP_085020354.1\|3001924_3002830_-\|hypothetical-protein	gnl\|CDD\|380141	pfam18741, MTES_1575, REase_MTES_1575. Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.	9.77392e-05
NZ_CP020715.1\|WP_085021534.1\|2995782_2996424_-\|YqaJ-viral-recombinase-family-protein	gnl\|CDD\|378216	pfam09588, YqaJ, YqaJ-like viral recombinase domain. This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit.	2.06392e-08
NZ_CP020715.1\|WP_085020358.1\|3005332_3005611_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	3.71277e-16
NZ_CP020715.1\|WP_085020356.1\|3003722_3004154_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	6.8317e-94
NZ_CP020715.1\|WP_085020355.1\|3003019_3003709_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	2.35053e-133
NZ_CP020715.1\|WP_085020357.1\|3004427_3005375_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	6.33622e-78
NZ_CP020715.1\|WP_174604479.1\|2993203_2993368_-\|hypothetical-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	0.00405888
NZ_CP020715.1\|WP_085020348.1\|2992379_2992895_-\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	2.9668e-64
NZ_CP020715.1\|WP_085020349.1\|2994938_2995706_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.35392e-87

>NZ_CP020715.1|WP_085020353.1|2999507_3000893_+|L-serine-ammonia-lyase
MTISAFDLFSIGIGPSSSHTVGPWRAAARFSALLAEEELLSRVARIRVELFGSLAATGRGHGTLPAVMLGLEGHDVETIDPDEKDDRVARWRASGRIRLAGGPTLPLAEGDIVLTHRMLPEHPNALTLTALDASGEMLASRTYYSVGGGFVVEDGAAPLRGVTSGSTGVGFHSAAELLDRASEDADGIAGVMMGVEVAGGRTASAVRARLLAIRDAMRGSAERGMTRSGTLPGGLEVRRRAAEWFARLREEDPGRDPAFALDWVDLVALAVNEENASGGRVVTAPTNGAAGIIPAVLDYALHYTPAGLASPDDAAVRFLLTAAAIGSIIKECASISGAEVGCQGEVGSAASMAAAGLAAVLGGTPAQVENAAEIAMEHSLGLTCDPIGGLVQIPCIERNAISAGKAVNAARMALRGDGAHHVSLDQVIETMRLTGADMHSKYKETARGGLALTVGVHVVEC
>NZ_CP020715.1|WP_085020352.1|2998670_2999207_-|GNAT-family-N-acetyltransferase
MVEVRRAVANDSAALARVAAATFPLACPPGSDPADIADFIAANLTEERFAEYLADPARVITVAEGEADRSEFAGYTMLVEGDPSDADVASALRLRPTIELSKVYVREQYHGAGVSRRLVDATIAAALDTTAKGVWLGVNDRNARAVRFYEKSGFERVGRKTFRLGSTLESDFVMERPL
>NZ_CP020715.1|WP_085020351.1|2997432_2998395_+|NADP-dependent-oxidoreductase
MRAAVMPHAGDAEVLEVAEVAVPLRINSEVLVHVAAAGVNPIDAKTRSGRGVSAAIEGYPYVLGYDFAGVVVETPYAAHPLSVGDEVFGVMSVPRGQGSYAEYVSVPSLQVTKAPKALTLVEAAGVPLAALTAWGMVVDVAKAHEGQRMLVHAGAGGVGHFAVQFAAYFGAHVIATGSPRNLSFLRGLGAAEVIDHTSTRFDEVLSGIDVVIDLIGNVHDETGTRSLTVLRPGGLLVNAPTGSWDTLAADAAAAGVRSSTYKFIPDASTLAVIARLLDSGDVRVHVEEVFPLDRAADAHRAIESGHTRGKVVLQVGALPL
>NZ_CP020715.1|WP_085020350.1|2996507_2997227_-|hypothetical-protein
MTRTSLRTAALVIAAGAALTGLVLIWVARLSATRFLYVSELGADGEPTAVVFRWAMTLVAASAAITAVWAGSIRPGVRWMASVAPPVVLAVAAVSFGVASQVTCTRYCPIPYGPSFTWQDFTHTSFAVVGFAAGCFVMLQVAVDRAHRTLARFSIASAVAVGAIAATGGLLSLARFAVELGGVLELIATTIALLWLVGLAVLLARAPAREVIPDAEARGPVTDRRTTVTRRDIPPAVFD
>NZ_CP020715.1|WP_085021534.1|2995782_2996424_-|YqaJ-viral-recombinase-family-protein
MLSFPWEEEAEPATTAPDVPPHLTRLVARSSDRRGWLRARARGVTGTDVARLSSRDAVNSVAYEKLNGTGFSGNVFTEHGKAREPEIAAWVLQEHGIAASDGLFHAERDARHLATPDGIRVDPDGALSLCEIKTTSKSWRSIPRSYLRQVWWQQYVLGAERTLVVWEQHEAFVPVGAVPMCRWVERDESEIEVLVRRADELLAAMRETWVRRR
>NZ_CP020715.1|WP_085020349.1|2994938_2995706_-|response-regulator-transcription-factor
MTLNRDLLAASGTTVKQPKLRRADGTAVRALVVDDESTLTDLLSMALRYEGWEVRTASEGRAAIQVAREFRPDVIVLDVMLPDIDGLQVLQRVRNDGHETPVLFLTAKDALDDRIAGLTAGGDDYVTKPFSLEELVARLRGLIRRSTLVVADADDPVVTVGDLQLDEDSHEVFRDGVSIELTATEFELLRYLMRNPRRVLSKAQILDRVWSYDFGGKSSVVEIYISYLRKKIDAGRPPMIHTVRGAGYMLKPASL
>NZ_CP020715.1|WP_174604581.1|2993451_2994885_-|HAMP-domain-containing-protein
MIIGVTSTLVLNDFLVDRLDSQLSDSAVRTEQFIRGQDGNGGPAPGIPLGQGEGTLAAIAAGGVVDNGLVLTADGRYQYLSAPQLAALDATISSVDAESVDIPGIGEYRVLSRTIVGDSAVIIGLPLDDVNATVTQLVVVIVIVTAAAMVVAGLIGLVVVRLSTRPLERMAATASRVARMRLDRGEVALAERVPSRDTDTRTEVGRVGAALNGMLEHVAAALTSRQRSENKVRQFVADASHELRTPLASIRGYAELTRRADVELPDDIRYSLGRIESEATRMTTLVEDLLLLARLDSRPELAMSDVDLSLVLVDAVSDAHAAGPDHHWDLDLPEEPLEVSADRHRLHQVFANLLANARVHTPPGTTVTVAAREGRADDGSRHAVVTIGDDGPGIEPDMLPTLFERFVRGDASRSRHAGSTGLGLAIVKAVTEAHEGTVSVESAPGSTVFTLTLPLAGDHSTPVEQSGRPLAEGDGPA
>NZ_CP020715.1|WP_174604479.1|2993203_2993368_-|hypothetical-protein
MNILLIIIAVIAVILLFTGGFVSSLNFLLWVGLILLVLAVIVFLVRLLTGSRRV
>NZ_CP020715.1|WP_085020348.1|2992379_2992895_-|50S-ribosomal-protein-L10
MANKEASVAELTDKFQSSTAVLLTEYRGLTVAQLKQLRKSISADATYAVVKNTLTKIAANNAGITVFDDELAGPSAIAFVHGDPVAVAKSLRDFAKANPLLVVKGGYFDGNPLSPEEVTKLADLESREVLLAKLAGAFKASLFGAAYLFNAPLSKAVRTVEALREKQESAN
>NZ_CP020715.1|WP_085020347.1|2991948_2992338_-|50S-ribosomal-protein-L7/L12
MAKLSTEELLEAFKELTLIELSEFVKAFEETFEVTAAAPVAVAGPAAVGGGAAAEEVEEKDSFDVILEAAGDKKIQVIKEVRALTSLGLGEAKALVDGAPKPVLEGANKETAEKAKAQLEEAGATVTLK
>NZ_CP020715.1|WP_085020354.1|3001924_3002830_-|hypothetical-protein
MTRYLALPRRLAARPFRASTSGLSRSRLRASDLAAPHRDVRVPAALADDLLMRCVALSTVLPEGACFSHRTAALLWGLPMPASDGDDLHVTVPAPVRAPRIRGVVGHQSRAVERVRVPAGLWVSTPGRTICDSAPDLDRVQLVSVVDHLLSTRTAADLSESIAAHPHPQAARLARALAEARPGVDSPRETALRLAIVDAGFPEPVVNGYVQSAEGFIVAKADLSYPRYRVAIEYEGDHHRTDRRQWFRDVARYRELESLDWIALRVTTADLTPSPRDLLAQLALHLRRRGCPLPTLRLPPR
>NZ_CP020715.1|WP_085020355.1|3003019_3003709_-|50S-ribosomal-protein-L1
MAQKSKAYRAAAEKIEAGKYYTPTEAVELARETGSKKFDSTVEVALKLGVDPRKADQMVRGTVILPHGTGKTARVIVFATGPAAEAAIAAGADEVGGDELIEKVAGGYTSFDAAVSTPELMGKVGRLGKVLGPRGLMPNPKTGTVTPNVAKAVEDIKGGKIEFRVDKHANVHFVVGKAGFSQEQLDENMKAALEEILRQKPSAAKGRYIQKGAVSTTFGPGIPLDVNAI
>NZ_CP020715.1|WP_085020356.1|3003722_3004154_-|50S-ribosomal-protein-L11
MAPKKKVTGLIKLQIQAGAANPAPPIGPALGQHGVNIMEFCKAYNAATESQRGNVIPVEITVYEDRSFTFILKTPPAAELIKKAAGVQKGSSTPHTVKVAKLTREQVRAIAEQKQVDLNANDIEAAEKIIAGTARSMGITVEA
>NZ_CP020715.1|WP_085020357.1|3004427_3005375_-|transcription-termination/antitermination-protein-NusG
MARPPRLRRRERFIAAAGSPPGRRTPTPPEEGIHPVSDPKPDQAGAPADLDALLDAIDAPADPEADAVIDEALTIDDFDEAAAVLDVIEDPDADKANEPLDADEAEAEVDPYDAFRKELRALPGKWYVIHSYAGFEKRVKSNIESRKVSMGMEDFIFQVEVPMEDVVEIKNGQRKLVTRVRIPGYVLVRMFLNEDSWSVVRHTPGVTGFVGNAHNPTPLRFDEAFNMLKSLVEVPEAPAAAKGGAAKGGKAVARSLPAEVDFEIGETITIKEGSFAGLPGSISEIKPESGKLTVLVSLFERETPVELSFDQVTKL
>NZ_CP020715.1|WP_085020358.1|3005332_3005611_-|preprotein-translocase-subunit-SecE
MARKVIDEPSEDVVENAKKERAARRNPFARIVLFIKQVFTELRKVVTPTRRELINYSLVVLVFVVIVMAIVVGLDQLFGWLALLVFGDASGS
>NZ_CP020715.1|WP_085020359.1|3005859_3006894_+|AI-2E-family-transporter
MRGHPFRIGFLATLGGLLAIALGFAFTQLSTVMICILASLFLALGLDPLVRWLERRRIPRGWAIVITFVLVIAFAVGVFFLIIPAVVDQTSQLVANIPQFARTITQQEWFTRLTGGSVDTKALVANLESFLSDPSNIATISGGVLKVGIAIVNGLSGGLLVVILTLFFLGSLDQVKRSLYVLVPASRREGVESISEQIVRSIGKYVSGQVILAGTNGVFGFIAMLIAGVPYAGALAVMAFLLALIPLIGTVISAIIITIVALTVSPAAAIGIGIYYLVYMQVEAYVFSPRIMSKAVDVPGLLVVIGALVGGTLLGVLGALIAVPVVASVLIVVKQVVVPRQQQL
>NZ_CP020715.1|WP_085020360.1|3006890_3007523_+|NAAT-family-transporter
MSDISTPALVASGIALLTITNPIGSLPIFLNLTKDLPAQRQRRIGIWVGVAVFAVLVVSLFAGKYILQAFGIDITSFRIAGNLLVASIGWAMLTAKQNIVTTDASSSPVVVPLAIPIIAGPGAISLIITFSESYSSLVDLLMGVVMILVVSLAIAVVLYFSPEVTKVVKPTAMSIVTRVFGLLLLSIAIQSILSALGDAFPVLTGTPAAS
>NZ_CP020715.1|WP_085020361.1|3007612_3008812_+|pyridoxal-phosphate-dependent-aminotransferase
MTEHSRISHRIASIAESATLKVDAKAKSLQAAGRPVISFAAGEPDFPTPPHIVEAAAEAVHDPKNHRYTPAAGLPELREAIAAKTLRDSGLEVSPAQIIVTNGGKQAVYQSFATLLDPGDEVLVPTPYWTTYPEAIRLAGGVPVDVFAGADQGYLVTVEQLEAARTERTKVLLFVSPSNPTGAVYSPEQTAEIGAWAEEHGLWVITDEIYQNLVYDGVRAVSIVEAVPALADRTILVNGVAKTYAMTGWRVGWMVGPADAIKGAANLQSHLSSNVSNVSQRAAIAALNGPQDTVETMRQTYARRRDEIVAGLNAIDGVVTPTPQGAFYVYPDVSGLLGRTWGGVTPTTSLELADLILDQAEVAAVPGEAFGPSGFLRFSYALSDENLAAGVARLQQLFA
>NZ_CP020715.1|WP_157127243.1|3008864_3011045_+|hypothetical-protein
MRGRLRSSPLRPGWSGGAAAPSLGAPLLAALLLCAGVVAAIGVGAVPAAAAAPPTSAGPIDGTVLVRGSDGSVPLTLTGTAEPGDVIDASLTWPGGELELCAVFAAPDGTWACDDLPALPDLVGTLELSADGGVFGSVTIGVISSPSLLADADDPSRLTIDPLAPWVSGSGTPGATVVVDVSDGDGCATAVDASGAWGCDLATGAAPAGRTVRAGQSWALDPATIAWGTPVSLVSGVSTVVGAPGDPETPGPAGTGGDPGVGSATGGDAGAVGGLGGVSDGGESGAADEGSPAAGPGAEGAPSSGVSDSGDAVRLTPVPAADVPPPASATGGAAGDRIAGAGSNAGAFGAGASGARTSASTPSSVANPVQSPFSAESGGATTFGSSLHGPAAFVEAGGPAFVFTGAAALGLVLLVMVPAGMLESTLEANSERLRRSAALRWLKRLPRVPRLPSRGRAGTVVSVALVVTATAALGAFVAPDAGSEGGFLRLAGAFVLASLGVNGLALGLMAAAARASGSRLEVTANGRSVFVTALTVLLSRAALLQPGFVFGVAIGAEATDRRPRTSRLVAAAGVVGLLVAGVGAWFAHAALLAAVGAGESADPAGSAAGGWGSFGVDVLTAMTIEALTGAVVAMIPLRFFAGAELWRGARTAWAALAALTAAAAMAALAPLPSAWNAVGGDTARWLLAFAAVTALTAAVWCWFRFVPERTTAPAGRHRTPRHRPAH
>NZ_CP020715.1|WP_174604480.1|3011875_3012658_-|alpha/beta-fold-hydrolase
MRLFGRTLRDAAPRLHVAVDEGEGPVVVLVHGIASSSASWEATIPLLTPLYRVIAIDVLGFGASVARPETMFTLDEHVAALHRTLVGLHLPGRFTLIGHSLGALISARYAAVHRRSVEHLILASPPIYPHARYIQERVARMRVGGYLAFYRYVREDKGRALGTLGRVRELLHVRGPQLDDVTWQAFALSMQNCIEQQTTMTDVAQVAVPVEIVYGSRDQVIVPGPVQALGVMHHVTLHEVRGADHFVRPPLAREIARLVR

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Crispr_ID: NZ_CP020715_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020715_8

3795248-3795347

Orphan

Consensus_repeat	Method
CCGTAGCCCGGATGCGGCTGCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020715_8

>merge|NZ_CP020715|8|3795248-3795347|CRISPRCasFinder
CCGTAGCCCGGATGCGGCTGCGGGCCGCTCTGCGGAGGCTGACCCTGCGGCTGCCCGTAGGTCGGGGGCTGCGGGCCGTAACCCGGATGCGGCTGCGGGC

>NZ_CP020715|8|8|3795248-3795347|CRISPRCasFinder
CCGTAGCCCGGATGCGGCTGCGGGC	CGCTCTGCGGAGGCTGACCCTGCGGCTGCCCGTAGGTCGGGGGCTGCGGG
CCGTAACCCGGATGCGGCTGCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020715.1\|WP_085020991.1\|3791860_3792487_+\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|223340
NZ_CP020715.1\|WP_174604538.1\|3787378_3789382_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_CP020715.1\|WP_085020996.1\|3795745_3796510_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP020715.1\|WP_085021002.1\|3803875_3804826_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP020715.1\|WP_085020986.1\|3787020_3787374_+\|PLDc-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379161
NZ_CP020715.1\|WP_157127323.1\|3796760_3797591_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP020715.1\|WP_085020998.1\|3798620_3798848_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085020997.1\|3797729_3798563_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235813
NZ_CP020715.1\|WP_085020993.1\|3792890_3793403_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085020999.1\|3798896_3799499_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP020715.1\|WP_157127324.1\|3799495_3800704_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP020715.1\|WP_085020989.1\|3790344_3791103_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187585
NZ_CP020715.1\|WP_085020985.1\|3786609_3786858_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085020992.1\|3792479_3792836_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085020994.1\|3793601_3794039_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319914
NZ_CP020715.1\|WP_085021001.1\|3801355_3803845_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020715.1\|WP_085020988.1\|3789474_3790308_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225107
NZ_CP020715.1\|WP_085021000.1\|3800808_3801327_+\|small-multidrug-efflux-protein	unknown	unknown	gnl\|CDD\|377692
NZ_CP020715.1\|WP_085020990.1\|3791186_3791783_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380057
NZ_CP020715.1\|WP_157127322.1\|3796630_3796792_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP020715.1\|WP_085020991.1\|3791860_3792487_+\|dihydrofolate-reductase-family-protein	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	2.36329e-15
NZ_CP020715.1\|WP_174604538.1\|3787378_3789382_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_CP020715.1\|WP_085020996.1\|3795745_3796510_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.9654e-30
NZ_CP020715.1\|WP_085021002.1\|3803875_3804826_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	2.40493e-65
NZ_CP020715.1\|WP_085020986.1\|3787020_3787374_+\|PLDc-N-terminal-domain-containing-protein	gnl\|CDD\|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	5.82926e-09
NZ_CP020715.1\|WP_157127323.1\|3796760_3797591_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.95621e-31
NZ_CP020715.1\|WP_085021000.1\|3800808_3801327_+\|small-multidrug-efflux-protein	gnl\|CDD\|377692	pfam06695, Sm_multidrug_ex, Putative small multi-drug export protein. This family contains a small number of putative small multi-drug export proteins.	0.000418046
NZ_CP020715.1\|WP_085020997.1\|3797729_3798563_+\|SDR-family-oxidoreductase	gnl\|CDD\|235813	PRK06482, PRK06482, SDR family oxidoreductase.	1.91914e-134
NZ_CP020715.1\|WP_085020999.1\|3798896_3799499_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.96233e-59
NZ_CP020715.1\|WP_157127324.1\|3799495_3800704_-\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	8.0858e-18
NZ_CP020715.1\|WP_085020989.1\|3790344_3791103_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.35137e-70
NZ_CP020715.1\|WP_085020994.1\|3793601_3794039_-\|VOC-family-protein	gnl\|CDD\|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.88574e-24
NZ_CP020715.1\|WP_085020988.1\|3789474_3790308_+\|hypothetical-protein	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.73513e-20
NZ_CP020715.1\|WP_085020990.1\|3791186_3791783_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|380057	pfam17926, TetR_C_21, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor found in Streptomyces coelicolor A3. Family members include HTH-type transcriptional repressor sco4008, which is suggested to be a transcriptional repressor of sco4007 responsible for the multidrug resistance system in S. coelicolor A3.	4.16298e-25

>NZ_CP020715.1|WP_085020994.1|3793601_3794039_-|VOC-family-protein
MEQRVSFITLAVADPRRSHAFYVDGLGWEPIFVGDDVLMLPVAERVILSLWSVDGFTAEIGEAPASGVAPITLAHNLATPAEVDAVLDEAARLGAPVSAGRTREWGGYSGYFSDPDGFRWEVAVNPGPTGEFVLPTRPGTAGSPT
>NZ_CP020715.1|WP_085020993.1|3792890_3793403_+|hypothetical-protein
MSGPAVHGFGSPGPSGHLVITDGPEAGTIRFDVELDRNLGGIWPRLHAVVIYRPDPAGGLIVRNEPVRRVAAYRGRSTLGYSAEQDPEVRRLTADALRGRLRRLGVSGDVTLSAIDTSVETGEAFGRVVGELMGALIADHLNGRDLRFEEAARNALDDATRRKGSVGGAP
>NZ_CP020715.1|WP_085020992.1|3792479_3792836_-|hypothetical-protein
MYGVPADESFAFFEGRRLDAVTYGRYQVALSFDGEVSIQIEGEIGVAAAGVPEVVVTDARDVARPLLDLLARTVVSVRVDPPTSLTLVFDDGTEVRAIDDLGPYESFTIHHGMSLWII
>NZ_CP020715.1|WP_085020991.1|3791860_3792487_+|dihydrofolate-reductase-family-protein
MATVVSSATMSLDGFIARDDDSVGALFDWYSAGDVEVPSANPDVRFRLTPTSAEFWRAWTSQVGALVVGRRLFDITRGWGGRHPLGVPVVVLTHTPPEDWSPAGAEDFRFVTSGIREAIAAASEIAGDGVVAVAAGTVAGQALQAGLLDAVAIDLAPVVLGSGRRYFGDVDPGTALLRDPDVVVAPGVTHLVYRLRPSAEEDAAAGVR
>NZ_CP020715.1|WP_085020990.1|3791186_3791783_+|TetR-family-transcriptional-regulator
MAWDVEGTRRRLREAALAEFAAHGFDGTTVAAIAARSGVNKERLYSYYGDKKALWDLVLTEELERLATAVELSGAGLDDIGEFAGATYDYHAAHPELGRLLQWEGLQDGPPARADIRTQHYREKIARFAAAQDEGLIDPDIDPGHLAFSLIALAAWWQTVPQLAEMITGAGPTDEHERAARRRFVVEAAKRLAAPRRA
>NZ_CP020715.1|WP_085020989.1|3790344_3791103_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTDTTRLPEQLTAPAPGTVALVTGANSGIGLEVARQLVERGVTVWMGARDAEKGREAAARLGDGARSLRIDVTEPTSIEAAAEQVGDLDILVNNAGVNPGAEDITGTSLEQLRTAYETNVFGLVAVTQAFLPALRRSAHPRIVNVSSGTGSLVWNSGPNPQFDWERVKGGGLAYRSSKTAVNAVTLLTAQALGEGFKVNALAPGLRATNLVPGMSVGGDPAEAATGAVRLALLPDDGPTGALWSWDGTRAPW
>NZ_CP020715.1|WP_085020988.1|3789474_3790308_+|hypothetical-protein
MDLTTMRPDDAALLQQATRMVRDQTGLSVAFGGLRGARSIRVSAVSGAPLRRLTSIDVRPARGLGGLAWVSGQPAVVRDYGRAEGITHDFDAQILGEGIASLAVAPIVVDLQVRGLLYAGSRESGSLDSTMASLTRVASSVAQELRVRDLVDERVQLRMRKAVVDDPAPDLRGALLRIAAETRDPDTARALEELLGSADAAPSSEAELTRRQRDVLALVAYGLTNAQIGARLSLSEVTVKSYLRAIMSRLSVRTRGQAVIEARRLGLLRPSPLDPAS
>NZ_CP020715.1|WP_174604538.1|3787378_3789382_-|acetate--CoA-ligase
MTRRSQVGTSPDSIDNLLHESRRFSPPPEFVENAVATAELYERAAADRLGFWAEQARELHWHTPFSDDRVLDWSNPPFARWFDDGEINVAYNCLDRHVEAGRGDRVALHWEGEPGDSRSLTYAELTAEVKKAANLLAGLGVGQGDRVAIYLPLIPEAVIAMLAVARLGAVHSVVFGGFSAESLRARIDDADAKLVITADGGYRKGKVSPLKPAVDAALALPDADGATGTHTVERVLVVKRGENEIDWTPGRDLWWHEEIATVDAEHIAQAFPAESPLFILYTSGTTGKPKGILHTSGGYLTQAAYTHRTLFDLHPETDVYWSTADVGWITGHSYVVYGPLANGATEVIYEGTPESPHPGRWWEIVEKYKVTILYAAPTAIRTFMKLGRQIPQRFDLSSLRLLGSVGEPINPEAWVWYRDVIGDGITPIVDTWWQTETGAIMISALPGVTILKPGSAQVPVPGISVDVVDEQGVSVGADQGGLLVVTEPWPSMARGIWGDPDRFIDTYWSRFGPTVYFAGDGARRDKDGDIWLLGRVDDVMNVSGHRLSTAEIESSLVANPMVAEAAVVGASDETTGQAVVAFVIIKQSHLEAASAEDAIPQLRKHVADQIGPIARPRDIYLVTELPKTRSGKIMRRLLRDVAEGREVGDTTTLADTTVMQVIATTVR
>NZ_CP020715.1|WP_085020986.1|3787020_3787374_+|PLDc-N-terminal-domain-containing-protein
MYVIFSFLLLALTIGALVDIIRRDEGQIKHLPKVVWVLLVVFLPMIGTVLWFTIGREYDRRPTENVSFGDPRRWHREPPPSPAAGPARDTRSTEEQLAELEREIEYYDKLRRPDQTP
>NZ_CP020715.1|WP_085020985.1|3786609_3786858_+|hypothetical-protein
MLLARADEIVASLSPGKRETVREIVINSVHRGAVDPSARRFLTAASGGPELADILAAALDSSAAGAVSAEGGPRSELGPAAS
>NZ_CP020715.1|WP_085020996.1|3795745_3796510_+|phosphatase-PAP2-family-protein
MSANHLSDVVVSRRSRFHRRFLFELRVVPAPARRRSFTLGGILMGLGALAFVALVVQVATGTGLTALDPGVAEWFRQKRFAEGTVVMDTLATVFGPVFLPLIILVVLVVWFAVARHLWRPLLLASGTVFGVICVQITAHVVQRPRPPMEYMLLGADGTFSFPSGHVTGVSDFFLLLTYLLVSRRPSLPAWIGGFALSAAMIACQIVARLYLGYHWLTDTLASVALAVAILGAVITVDTWRTTRAAPATTTAEVR
>NZ_CP020715.1|WP_157127322.1|3796630_3796792_+|hypothetical-protein
MSTSRTAVSPADGEAVSTRPTRRALSLDAIVLGSAALATVGVTVTSLATLGIR
>NZ_CP020715.1|WP_157127323.1|3796760_3797591_-|helix-turn-helix-domain-containing-protein
MDARNELGTFLRARRELVQPEDVGLPRGATRKVHGLRREEVAALAGISSEYYLRLERGRDTHPSDQVLDALARVLQLDHESRGYLLDLARARPSSPPAEGDRLPADAQLLLDTIGAPAFIVNRYRDVLAANAAATELSPMMRPGVNRIRALFLDAETQRAHPDWEQHAASMVAQLRADLGTRTDDPRAQTLIGELTMKSSLFRTLWDRHDVGRGGRSDTLIVRPGRPPLAFRQEKLQLVADPALLLVVYLPQTAPSDVPPADSGEGLSGCRAWPET
>NZ_CP020715.1|WP_085020997.1|3797729_3798563_+|SDR-family-oxidoreductase
MTERTWFITGINSGFGRQLTEQLLAAGDRVVGTVRRDGSVADLERRYGDRLVVPHLDVTDVPAVRRVVDDAFARLGRIDVVVNNAGYGLFGAAEELTDEQVQHQLATNLLGSIQVTRAALPHLRGQGGGRIVQLSTYGGLATNPGASLYHASKWGIEGFMESLAKETAPFGIEVTIVEPGGARTEFRFDSLATATPLAAYDDTPAAMTRAAGDRSRPSLGDPAKMAAAIIASVDVSPAPRRLVLGSDSYRFITAALQERLAEIVPQAGSAAATDWSD
>NZ_CP020715.1|WP_085020998.1|3798620_3798848_+|hypothetical-protein
MKTSPTGARRRRLKLIAVAVWLGLGVTAAVVALILGHPVWLLLIALLVMGPYLALASGTRQWTNTPQGFRAWLDR
>NZ_CP020715.1|WP_085020999.1|3798896_3799499_-|response-regulator-transcription-factor
MIRVLIADDEDMIRTALAALLRLEPDLEVVAECRDGESAIAEAERVQPDVCLLDLEMPGLDGVDTAARVLRQVRTRCVIVTRHARPGVLRRALGAGVHGFLPKSRPADDVASVIREVATGRRYVDPEIAADALSDERSPLTDRELDVLRAGARGETIAEIAASLHLSAGTVRNHVSSVLGKLGLATRQQATIHARERGWI
>NZ_CP020715.1|WP_157127324.1|3799495_3800704_-|histidine-kinase
MGRRTRDKSHGRTVAGVSTPTAAARARDVRVTWWYTVLSIIMLQLFGLVVWALVLVIDEPPLHTVLYLAGAAGSVASAILLLVRYRREPLDEGDTTARRPVWPLVLAGVASGALAGAAAGSLLLGVTLAAQALCLVSWRSGIRLRLVLLLVAVIVAAWVVEATHLDPDGRVARILGMGLFIAMLPPLSATSLWWWDIVRELDRARRAEGRLAAAQERLRLASDLHDLQGHHLQVIALQLELAEKMLARDPAAAVEQVRLARHSVDEARRGTRELAVRFRGVPLPDELANAADLLRAAGLRVDLEIAPDAADAPADVLGPVIRECTTNVLKHGGGGSASLSLLHRDDAWVFTIENDVREPRGAGGSGLDGIAERIGRVRGTVEAGRSGDRFRVAVTVPEGVMA
>NZ_CP020715.1|WP_085021000.1|3800808_3801327_+|small-multidrug-efflux-protein
MSSPVTDLVLGFQNLVAEVPTLVQPLVVALAGAVPFIEGEGAAGIGIVGGIPPIVAALAGAIGNLICVTIVVLAAARVRTAVTTRRASASAGAGAEKRTSARREKFERAYHRYGTPGVSLLGPLLLPTQFTAAALTSTGVPPRRVLAWQAAAIVLWTTVITLIVTGVIRAVA
>NZ_CP020715.1|WP_085021001.1|3801355_3803845_-|hypothetical-protein
MTRSASVRRRALGGGAGVALAVAALVAVPVAPVFAATTTVSTLAELQGALADCTSAPNTIALGADISAPGAALTVPCDTTIDLGTHDLSVLNVVIAEGEGLTVDGPTDGSGGTLTADATNAANGTAGIQTTGATLTVTGGTVTARGADTTGPGIGGDRSDAGSLVVAGGVVNAYADGYSAAVGGGYPRSAGGSVTVTSGALNAYAEGPYTVAVGGAGGGASGNGGAGAQVTVTGGSLTASASREYGTAIGGGVAGLDAADLGGAGGSLTIGAGAEVTATAPRNAIGSGWNVFTDVPTGDFGAVDVDGTLRLPSGGLYVGTDAAPGPEITVGTSGRIVGSTADPATGAGISGPGSIDNQGSITLAPPSGAVTGNNRLVRFTPTAPSVRVFAPSFADGARTLPAPPTGTQWNTAADGSGDWFTTTSSTAGSGTLDLSAVVPGTIVVSTDPAALTATAGEPYDFPVTVTGPTGAPLVPQPTVDYTSTDCTIGAGGVFTVARSCSITASTTVQGVPLSKTFTIQVVAGPLAALTLTPASATVTQGASLAFLVSGVDAEGNAVDVTAAVLTSSSPADTVAGRSVTFSGAGAHTVTATLGSVSTTAAITVVAGPLSSLSITPSTTTVPQGGTVAFTVTGADAAGNPVDASAAVLTSSGTADAVDGHAVTFSGAGARTVTAALAGVTTTAFVEVVAGPLATLTITPSSSSVDQGGTLDFTVTGTDAAGNPVDTSDAVLTSSVATDVVDGFSVTFPHASPHTITATIGAVSASVTIQVVPAPAPTPGPSPAPAPAPAGLANTGADGGAATLAGGAAVALLLLGGVLLLIRRSVRRVG
>NZ_CP020715.1|WP_085021002.1|3803875_3804826_-|NAD(P)-dependent-oxidoreductase
MTTGTVGFIGLGIMGVPMATNLVRAGFDVVVWARSPSAVDELVAEGARAVDDVAGVFEAASTVVLMLRDEPAVDAVLARGTDAFAGLVSGRTVVQMGTFTTTFSRALADEVGATGGRYVEAPVSGSRGPARDRTLVAMLAGDPDAVAEVEHVVAAMCAQTFRCGAIPAALSMKLAVNTFLITMVTGLAETFHFAARSGVDLDVLREVLAAGPMASVVSRGKAQKLTDRDLSAQAAVTDVLKNARLAEDAARAAGSSHPLMTASRELYEEAAAAGLGHLDMIAVIAALDERAGVDPKGALAVQVRDGRDCESCPPSS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_AP017656	Sphingobium cloacae strain JCM 10874 plasmid pSCLO_2, complete sequence	153038-153070	8	0.758
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP011450	Sphingomonas sanxanigenens DSM 19645 = NX02 plasmid pNXO2, complete sequence	141568-141600	8	0.758
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP018821	Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence	202835-202867	8	0.758
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP020539	Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence	647180-647212	8	0.758
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	CP021182	Sphingomonas wittichii DC-6 plasmid pDC01, complete sequence	65793-65825	8	0.758
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP041018	Sphingobium fuliginis ATCC 27551 plasmid pSF1, complete sequence	178297-178329	8	0.758
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP023450	Rhizorhabdus dicambivorans strain Ndbn-20 plasmid p1, complete sequence	116595-116627	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP023451	Rhizorhabdus dicambivorans strain Ndbn-20 plasmid p2, complete sequence	150329-150361	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP017078	Novosphingobium resinovorum strain SA1 plasmid pSA3, complete sequence	132077-132109	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_AP018666	Sphingobium amiense strain DSM 16289 plasmid pSAMIE_3, complete sequence	104819-104851	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP010956	Sphingobium sp. YBL2 plasmid 2pYBL2-2, complete sequence	36742-36774	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP053022	Sphingobium yanoikuyae strain YC-XJ2 plasmid p-A-Sy, complete sequence	266516-266548	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP018225	Tardibacter chloracetimidivorans strain JJ-A5 plasmid pHSL4, complete sequence	129412-129444	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP013265	Sphingobium baderi strain DE-13 plasmid pDE1, complete sequence	151893-151925	9	0.727
NZ_CP020715_6	6.1\|2177366\|33\|NZ_CP020715\|CRISPRCasFinder	2177366-2177398	33	NZ_CP004389	Thalassospira xiamenensis M-5 = DSM 17429 strain M-5 plasmid unnamed, complete sequence	52291-52323	9	0.727

1. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_AP017656 (Sphingobium cloacae strain JCM 10874 plasmid pSCLO_2, complete sequence) position: , mismatch: 8, identity: 0.758

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagttcc	Protospacer
******** ************* **. . *. *

2. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP011450 (Sphingomonas sanxanigenens DSM 19645 = NX02 plasmid pNXO2, complete sequence) position: , mismatch: 8, identity: 0.758

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagttcc	Protospacer
******** ************* **. . *. *

3. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP018821 (Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence) position: , mismatch: 8, identity: 0.758

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagttcc	Protospacer
******** ************* **. . *. *

4. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP020539 (Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence) position: , mismatch: 8, identity: 0.758

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagttcc	Protospacer
******** ************* **. . *. *

5. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to CP021182 (Sphingomonas wittichii DC-6 plasmid pDC01, complete sequence) position: , mismatch: 8, identity: 0.758

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagttcc	Protospacer
******** ************* **. . *. *

6. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP041018 (Sphingobium fuliginis ATCC 27551 plasmid pSF1, complete sequence) position: , mismatch: 8, identity: 0.758

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagttcc	Protospacer
******** ************* **. . *. *

7. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP023450 (Rhizorhabdus dicambivorans strain Ndbn-20 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagatcc	Protospacer
******** ************* **. .  . *

8. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP023451 (Rhizorhabdus dicambivorans strain Ndbn-20 plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagctcc	Protospacer
******** ************* **. . .. *

9. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP017078 (Novosphingobium resinovorum strain SA1 plasmid pSA3, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagatcc	Protospacer
******** ************* **. .  . *

10. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_AP018666 (Sphingobium amiense strain DSM 16289 plasmid pSAMIE_3, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagctcc	Protospacer
******** ************* **. . .. *

11. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP010956 (Sphingobium sp. YBL2 plasmid 2pYBL2-2, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagatcc	Protospacer
******** ************* **. .  . *

12. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP053022 (Sphingobium yanoikuyae strain YC-XJ2 plasmid p-A-Sy, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagatcc	Protospacer
******** ************* **. .  . *

13. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP018225 (Tardibacter chloracetimidivorans strain JJ-A5 plasmid pHSL4, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagatcc	Protospacer
******** ************* **. .  . *

14. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP013265 (Sphingobium baderi strain DE-13 plasmid pDE1, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
agcgccggtacgctgcatgcccagcccagatcc	Protospacer
******** ************* **. .  . *

15. spacer 6.1|2177366|33|NZ_CP020715|CRISPRCasFinder matches to NZ_CP004389 (Thalassospira xiamenensis M-5 = DSM 17429 strain M-5 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.727

agcgccgggacgctgcatgccctgctggctcgc	CRISPR spacer
gccgttgggacgctgtatgccatgctggctgca	Protospacer
. **..*********.***** ********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2975418 : 2986085

Bacillus_phage(25.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085020337.1\|2975418_2976399_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A0N7CCA3	Skermania_phage	4.6e-149	82.3
WP_157127469.1\|2976438_2978520_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	1.2e-207	52.5
WP_114704137.1\|2978570_2979047_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	3.3e-12	38.5
WP_085020339.1\|2979053_2979290_-	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	5.0e-17	55.3
WP_085021531.1\|2979919_2981371_+	M1 family metallopeptidase	A0A0P0IY26	Acinetobacter_phage	3.1e-16	26.4
WP_085020340.1\|2981463_2982618_-	cystathionine gamma-synthase	A0A0B5JD48	Pandoravirus	2.4e-24	31.7
WP_085020341.1\|2982659_2984030_-	cystathionine beta-synthase	A0A1X9I5F1	Streptococcus_phage	3.0e-53	40.8
WP_085020342.1\|2984171_2986085_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	4.2e-37	26.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP020716

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP020715

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection