CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP019752	Lactobacillus brevis strain TMW 1.2113 plasmid pl12113-2, complete sequence	0 crisprs	NA	0	2
NZ_CP019751	Lactobacillus brevis strain TMW 1.2113 plasmid pl12113-1, complete sequence	0 crisprs	NA	0	2
NZ_CP019753	Lactobacillus brevis strain TMW 1.2113 plasmid pl12113-3, complete sequence	0 crisprs	NA	0	0
NZ_CP019750	Lactobacillus brevis strain TMW 1.2113 chromosome, complete genome	2 crisprs	cas2,csn2,DinG,csa3,DEDDh,cas3	11	3
NZ_CP019754	Lactobacillus brevis strain TMW 1.2113 plasmid pl12113-4, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 28230

unidentified_phage(30.0%)

holin,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020923847.1\|1588_1867_+	BRCT domain-containing protein	NA	NA	NA	NA
WP_048001079.1\|2879_4049_-	relaxase/mobilization nuclease domain-containing protein	NA	NA	NA	NA
WP_100223170.1\|5187_5975_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_003581702.1\|6049_7321_-	oxidoreductase	NA	NA	NA	NA
WP_003581705.1\|7317_8076_-	FAD:protein FMN transferase	NA	NA	NA	NA
WP_016511778.1\|8072_8537_-	FMN-binding protein	NA	NA	NA	NA
WP_016511777.1\|8882_9380_+	hypothetical protein	NA	NA	NA	NA
WP_016511776.1\|9865_11800_-	hypothetical protein	NA	NA	NA	NA
WP_003581715.1\|11809_12757_-	glycosyltransferase family 2 protein	F1C5B0	Cronobacter_phage	2.4e-46	37.5
WP_016511775.1\|12738_13410_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_003581721.1\|13399_14050_-	VTT domain-containing protein	NA	NA	NA	NA
WP_048001087.1\|14266_15625_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.2e-17	27.9
WP_085763788.1\|15634_16330_-	response regulator transcription factor	W8CYM9	Bacillus_phage	6.3e-36	36.7
WP_024526065.1\|16497_17421_+\|transposase	IS30 family transposase	H7BVY4	unidentified_phage	6.7e-33	31.9
WP_085763789.1\|18285_20124_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	6.8e-69	28.9
WP_016511950.1\|20167_20380_+	tyrosine recombinase	A0A1S5SEW4	Streptococcus_phage	5.4e-07	45.6
WP_085763790.1\|20397_21327_-\|transposase	IS30-like element ISLpl1 family transposase	H7BW47	unidentified_phage	2.0e-24	34.1
WP_076619057.1\|21899_22061_+	LtrC-like protein	NA	NA	NA	NA
WP_016511417.1\|22199_22304_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_024855730.1\|22646_23423_+	hypothetical protein	NA	NA	NA	NA
WP_060416966.1\|23530_24115_+	recombinase family protein	M9Q1K0	Clostridium_phage	7.7e-19	34.2
WP_024526065.1\|24305_25229_-\|transposase	IS30 family transposase	H7BVY4	unidentified_phage	6.7e-33	31.9
WP_002825823.1\|25532_26738_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_024855732.1\|26853_28230_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.3e-11	22.5

DBSCAN-SWA_2

32550 : 33480

unidentified_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015474656.1\|32550_33480_-\|transposase	IS30-like element ISLpl1 family transposase	H7BW47	unidentified_phage	5.2e-25	34.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP019751

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 8948

unidentified_phage(40.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041816175.1\|315_645_+	DUF5388 domain-containing protein	NA	NA	NA	NA
WP_085763760.1\|894_1377_-	RepB family protein	NA	NA	NA	NA
WP_085763761.1\|1559_2483_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.1e-30	31.4
WP_033615067.1\|2811_3366_-	recombinase family protein	A0A1J1J8Z4	Escherichia_phage	6.8e-33	45.1
WP_085763762.1\|3741_5778_-	KUP/HAK/KT family potassium transporter	M1HZV6	Acanthocystis_turfacea_Chlorella_virus	1.0e-62	33.2
WP_085763763.1\|5943_6645_-	response regulator transcription factor	A0A1J0GWE0	Alteromonas_phage	4.8e-07	29.1
WP_085763764.1\|8018_8948_+\|transposase	IS30 family transposase	H7BW47	unidentified_phage	4.8e-23	33.7

DBSCAN-SWA_2

18616 : 20752

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085763773.1\|18616_20752_-	type IA DNA topoisomerase	A0A1X9I6W8	Streptococcus_phage	5.6e-107	46.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP019750

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019750_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019750_1

10605-10731

Orphan

Consensus_repeat	Method
TTACTTTTGGCTGTGATTGCCCACCCGCTGGTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019750_1

>merge|NZ_CP019750|1|10605-10731|CRISPRCasFinder
TTACTTTTGGCTGTGATTGCCCACCCGCTGGTCGTGGCAAATGAGCTGGAACGTAGTATGACGTGGACATATTGGTTAGGGTGCCTGTGTCAATTACTTTTGGCTGTGATTGCCCGCCCGCTGGTCG

>NZ_CP019750|1|1|10605-10731|CRISPRCasFinder
TTACTTTTGGCTGTGATTGCCCACCCGCTGGTCG	TGGCAAATGAGCTGGAACGTAGTATGACGTGGACATATTGGTTAGGGTGCCTGTGTCAA
TTACTTTTGGCTGTGATTGCCCGCCCGCTGGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019750.1\|WP_011666824.1\|12211_12448_+\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NZ_CP019750.1\|WP_080769713.1\|21990_24006_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|226404
NZ_CP019750.1\|WP_085762600.1\|16026_16803_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	unknown
NZ_CP019750.1\|WP_011666823.1\|11616_12183_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915
NZ_CP019750.1\|WP_085762598.1\|9126_10389_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP019750.1\|WP_085762597.1\|3414_4569_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NZ_CP019750.1\|WP_052471865.1\|20313_20943_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP019750.1\|WP_085762599.1\|13810_15418_-\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869
NZ_CP019750.1\|WP_024526042.1\|1628_2768_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NZ_CP019750.1\|WP_085763713.1\|21023_21734_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP019750.1\|WP_156646765.1\|9_1359_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NZ_CP019750.1\|WP_011666818.1\|3187_3415_+\|S4-domain-containing-protein-YaaA	unknown	unknown	gnl\|CDD\|274378
NZ_CP019750.1\|WP_011666821.1\|6537_9072_+\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NZ_CP019750.1\|WP_021741384.1\|4572_6516_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|235542
NZ_CP019750.1\|WP_011666822.1\|11286_11583_+\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NZ_CP019750.1\|WP_085762601.1\|16950_18135_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP019750.1\|WP_085762602.1\|18156_19758_-\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869

Protein	Function_ID	Function_description	E-value
NZ_CP019750.1\|WP_011666824.1\|12211_12448_+\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.12666e-36
NZ_CP019750.1\|WP_080769713.1\|21990_24006_+\|DHH-family-phosphoesterase	gnl\|CDD\|226404	COG3887, COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms].	0
NZ_CP019750.1\|WP_011666823.1\|11616_12183_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	7.3001e-60
NZ_CP019750.1\|WP_085762598.1\|9126_10389_-\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	8.09545e-59
NZ_CP019750.1\|WP_085762597.1\|3414_4569_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	3.6394e-163
NZ_CP019750.1\|WP_052471865.1\|20313_20943_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.63041e-10
NZ_CP019750.1\|WP_085762599.1\|13810_15418_-\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.8719e-165
NZ_CP019750.1\|WP_024526042.1\|1628_2768_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	1.36694e-150
NZ_CP019750.1\|WP_085763713.1\|21023_21734_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.75515e-14
NZ_CP019750.1\|WP_156646765.1\|9_1359_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP019750.1\|WP_011666818.1\|3187_3415_+\|S4-domain-containing-protein-YaaA	gnl\|CDD\|274378	TIGR02988, YaaA_near_RecF, S4 domain protein YaaA. This small protein has a single S4 domain (pfam01479), as do bacterial ribosomal protein S4, some pseudouridine synthases, tyrosyl-tRNA synthetases. The S4 domain may bind RNA. Members of this protein family are found almost exclusively in the Firmicutes, and almost invariably just a few nucleotides upstream of the gene for the DNA replication and repair protein RecF. The few members of this family that are not near recF are found instead near dnaA and/or dnaN, the usual neighbors of recF, near the origin of replication. The conserved location suggests a possible role in replication in the Firmicutes lineage. [DNA metabolism, DNA replication, recombination, and repair].	4.94751e-31
NZ_CP019750.1\|WP_011666821.1\|6537_9072_+\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NZ_CP019750.1\|WP_021741384.1\|4572_6516_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|235542	PRK05644, gyrB, DNA gyrase subunit B; Validated.	0
NZ_CP019750.1\|WP_011666822.1\|11286_11583_+\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	3.24472e-37
NZ_CP019750.1\|WP_085762601.1\|16950_18135_-\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	2.22768e-99
NZ_CP019750.1\|WP_085762602.1\|18156_19758_-\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.37182e-175

>NZ_CP019750.1|WP_085762598.1|9126_10389_-|ISL3-family-transposase
MSQDQSTRLLLQIKDKNITHLRVSDTKRDALRVYGTLSYKLNVCPYCAQRQVVCNGHKTAYVRLPNVSERTVILILRKQRFRCKVCGKTSIAQTPVVRRQHQISENTRHAIDKSLIEDRTMKSIADQYNVSTNFVSRRILALSKQTMPAYDGLPQTLCIDEFRSTSNQMSFITIDGQKHDIITILPSRQTNEIKQFFLNHYSLKNREQVTQVVMDLNAQYQTVIRYLFPNAKLIVDNFHLVQMTLRALNQTRVQLMKRYHPDTPEYRVLKPYWRLYLMNYGALEKSQPQWFSHLRNRLTQEQLIWSGLNLSHEFENTYFTAHKLVEAFRNRDYAAFTSTLDEVENVSPQLFTTIKTFIKNRKLIQNMTSSTLSNGPIEGVNRKIKQIKRTAYGYRNWKNFVFRIQIEFKIRVKKRNPVRK
>NZ_CP019750.1|WP_011666821.1|6537_9072_+|DNA-gyrase-subunit-A
MADQDYLGRVTDVDLSQTMRTSFLDYAMSVIVQRALPDVRDGLKPVHRRILYDMHELGITPDKPFRKSARMVGDVLGKYHPHGDSAVYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARLSKIAMEMLRDINKDTIDFQDNYDGSEREPVVLPSRFPNLLVNGASGIAVGMATNIPPHNLTEVISALHILMKNPDASLADLMEALPGPDFPTGGIVMGKAAIRRAYETGKGTITLRAKVDIEEEKNGKQRIVATEIPYMVNKAKLIERIAELARDKRIEGITDVNDETDRTGMRIVIDVRRDASAEVILNNLYKMTLMQTSFGINMLAIVNGAPKVLGLKAILQYYLEFQLEVIRRRTEFDLRKAEARAHILEGLRIALDHIDEIITIIRQSQTADVAKQELITRFSLSDKQSQAILDMRLVRLTGLEREKVEKEYADVMANIKDYKEILASKERQQAIIYEELLEIQNKFGDDRRTELMVGEVLSLEDEDLIAEEDVVVSLTHNGYIKRLPTSEFKAQNRGGKGVQGMGVHDDDFIEHLVATSTHDMLLFFTNTGKVYRMKGYEIPEYGRTAKGIPVINLLGINNNEHVQAVINVANPGENDNRDLFFTTVQGTVKRTPVDEFANIRSNGLKAINLKEDDELIDVDIINADANMIIGTHLGYAVSFAATDVRSMGRSATGVRGIRLREHDYVIGASVLKPDSKVFVISEKGYGKQTAAAEYPIKGRGGKGIKTVNVSTKNGPLAGLTTLDGDEDIMLVTNKGVMIRFSASDVSETGRATLGVHLIRLADDTAVATMAKVAKEDETADEAPVVDGETPATTDGPVVPESDDPTEA
>NZ_CP019750.1|WP_021741384.1|4572_6516_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MADEKETKAQQAREYDASQIQVLEGLEAVRKRPGMYIGSTSSQGLHHLVWEIVDNGIDEALAGFADEIHVTVNQDNSITVTDNGRGIPVDIQKKTGKPALETVYTILHAGGKFGGGGYKVSGGLHGVGASVVNALSTDLEVQVIRGGKKYAIAFDHGHVKTPMHVIEEGLPQDQHGTIVHFLPDPDIFRETTVFDIKTLTTRIRELAFLNKGLRITIRDERPEKPTEEDFLYEGGIRHYVDYLNENKETLFEPPIYVEGQENGITVEVALQYTDDYHNNLLTFTNNIHTYEGGTHEEGFKRALTRVVNDYARQNKLMKDNEANLTGDDVREGLTAVVSVKHPDPQFEGQTKTKLGNSDARTAVDHTFADHFMRFMMEHPDVARKIVDKGTLASKARVAAKRAREVTRKKSGLEISNLPGKLADNTSKDPEISELFIVEGDSAGGSAKQGRSRLTQAILPIRGKILNVEKASMDRILANEEIRSLFTAMGTGFGNDFDVSKANYHKLILMTDADVDGAHIRTLLLTLVYRYMRPLLDAGFVYIACPPLYRVRQGKMQRYLDSDEELKDLLGQLPPSPKPQIQRYKGLGEMDAEQLWETTMNPENRRLLRVDAQDAINADQVFTMLMGDKVAPRREFIENNATFAELDV
>NZ_CP019750.1|WP_085762597.1|3414_4569_+|DNA-replication/repair-protein-RecF
MYLQELQLQQFRNYPTAKLTFGQGINVLLGENAQGKTNLLEAIYVLALTRSHRTANDHDLVNWQAKTAKVSGRVVKAAGAVPLELTFSRQGKRARVNHLEQARLSQYVGQLNVILFAPEDLAIVKGAPTVRRRFMDMEFGQMNPRYLYNLSQYRTLLKQRNRYLKDLQHKQNKNLLFLSVLSDQLAAFGAEIIAQRLAMLQKLEHWAQAIHGEISQQREELTFHYATQVADDQLTDVPTITAALSALYAKQQDKELYQGTTLVGPHRDDLHFQVNGKNVQTFGSQGQQRTTALSVKLAEIDLMKEETGEYPVLLLDDVLSELDDARQTHLLTAIQDKVQTFITTTSLSGITRQLIKDPTIFHVAEGTVVADAVDSDDPAASKED
>NZ_CP019750.1|WP_011666818.1|3187_3415_+|S4-domain-containing-protein-YaaA
MKKEVLIETPYITLGQLLKEESVISTGGQAKWYLQENTVNINDEPDNRRGRKLYPGDTVAVPEAGLFFIRSKQGE
>NZ_CP019750.1|WP_024526042.1|1628_2768_+|DNA-polymerase-III-subunit-beta
MKFTINRAAFIKELNNVSRAISSKTTIPILTGLKIVASDAGLLLTGSNADISIETLIRADNPDVGLTIDEPGSIVLTARFFSEIVKRLPEKEMTVEVKDGFQTEITSGAAAFNINGQDANNYPHLPEIDAADSVVLSGAVFKELISQTVIAVSNQESRPILTGIHFVLNDNQFLAVATDSHRLSQRQIELPTPSEASFDVIIPGKSLTELSRMIGDDDADVKMQFSENQVLFLLGDTSFYSRLLEGNYPDTSRLIPKESSTTVEFEAPELLAAVERASLLSHESRNNVVKLTLTPTDHQVTIFSNSPDVGNVEEELAPKEIGGEPLEISFNPDYMKDALHSFGQATIRVAFTSALRPFTLVPTEDTSNFIQLITPVRTF
>NZ_CP019750.1|WP_156646765.1|9_1359_+|chromosomal-replication-initiator-protein-DnaA
MLTLWTDIKALFEENNSKTAYATWIETAKPIALDGNKLTLELPSPLHRDYWTHQHLDQQLVEYAYQAAHEDIQPVLILENERQQQATLKAKTAPVAAGEPVEPTPTFMKETALNSRYTFDTFVIGKGNQMAHAAALVVSEEPGVMYNPLFFYGGVGLGKTHLMHAIGNKMLEDRPDTKVKYVTSEAFTNDFINAIQTRTQEQFRQEYRNVDLLLVDDIQFFANKEGTQEEFFHTFNALYDDGKQIVLTSDRLPNEIPKLQDRLVSRFAWGLSVDITPPDLETRIAILRNKADADQIDIPDDTLSYIAGQIDSNVRELEGALARVQAYSQLMHQPIATDLAAEALKSLNLANASDAVTIPVIQDRVAKYFDVSLKDLKGKKRKKAIVMPRQIAMYLSRELTEASLPRIGNEFGGKDHTTVIHAYDKITESLKTDPQLQKDIDSLKDDLRR
>NZ_CP019750.1|WP_011666822.1|11286_11583_+|30S-ribosomal-protein-S6
METTKYEITYIIRPDLDDAAKTALVERFDKILTDNGAELINSKDWSKRRFAYEIGGFNEGIYHVITLNATDDKGLNEFDRLAKINDSILRHMIVKRED
>NZ_CP019750.1|WP_011666823.1|11616_12183_+|single-stranded-DNA-binding-protein
MINRVVLTGRLTRDVDLRYTQGGAAVATFTLAVDRRFTNQQGEREADFVSCVIWRKSAENFANFFHKGSLVGIEGRIQTRNYENQQGQRVYVTEVVVENFSFLEPRSRNENNGGGNYNGGSMNNNAPQNQNQNANPYTSGNPAPAAPSQGMAPNSGSNNQNSNANNNAADPFANSGDSIDISDDDLPF
>NZ_CP019750.1|WP_011666824.1|12211_12448_+|30S-ribosomal-protein-S18
MAGQRRGGRRRRKVDFIAANHIEYIDYKDTDLLRRFISERGKILPRRVTGTSAKNQRKLTIAIKRSRIMGLMPFVSEE
>NZ_CP019750.1|WP_085762599.1|13810_15418_-|peptide-ABC-transporter-substrate-binding-protein
MKHFVWTLPVGLLLLASLSGCGHAAGHTTNKNRPLNVTLASEPATADPNKSTDTNSGSLIFQTMEGLYTYNRNGKITAGVATKMVKPTNNGKTYTFTLKKQAKWANGQRVTAQDFVTSLQRMANPKTKAQYASVLSAFKNFTAVQTGKVAPSKLGVKALSSTKLQFQLTKAVPYFNDLIASEYYPLNTAAVKKYGAQYGTSAAKTVSNGAYKLVGWTGSNASWSYVKNRHYWNADSVKINRVKVAVTKDESTAANLFNADKVQETTVTGNYVRANRNSKNLHTHLTGRLQYLYINSKKTATNSTNLRQAISDAINRSQLTKSVLQDGSKAALSAVPTGDQKNPQTGQDMAAQVGNLLPQDKQQAKTYWQKYLKETGQTKATLNLLTDDTDDDKKVGTYLQSELEKTLPGLTITTTAIPHAQHVARDFAGNFELNLTGWSTSWLDAADFLSLAAKGNSVNFTNWSDTTFNQLLTKANSQTGLARYNGLMAADKRLMAVKGYIPLYQPSEAKLISNQVGGLTYTLLHEAKYQYAYWK
>NZ_CP019750.1|WP_085762600.1|16026_16803_+|D-alanyl-D-alanine-carboxypeptidase
MKKVVMGSLVLGAVMGGLAVVQMPQHAQAATYQVKKLMGFRHPTSYYAKSAKSGYLWNKSHTKRLHNLKNYPKTTWYATAKYSMKSVRNSGTYLKVINGTGKAEGYVWTGYLKKGVNPANPNGTLTDPFGAAMSTYNVDDNLNKQLVALFPGTIPDEPLQLAADFIFANAGANPDDYTSVIEELVGAENEPSVFRLSSDKRIQKNQNFLSFQRNSLKEELVTKHKKFTSFKGYRIGAYAFPKHDKRYGESMILLLPSN
>NZ_CP019750.1|WP_085762601.1|16950_18135_-|amidohydrolase-family-protein
MTQTTFYNCYFFDGTNDQNQTDTWFTVDDTGRITAIGHGTPTDTTDTVDLHGQYVMPGFINVHTHITSDPDAFSGHFGGSETESAVFAYENLRTLLKSGVTYIRECGTTYDIDIKLKRLQRQGKLPQTPHMMASGRAFSMTGGHGDGPHAAYLVDSQDEMRKAVRTAFKGGAECIKVMATGGVMTPNDFMEDPQLSTAEIAVAVEEAHHKRRIVAAHAEGNPGIQNALNAGVDSIEHGFYVNSDEAHQMVEQGTYLTPTLVAEAAVANQGQGQLPDWEVKKAADAMADTYRNLSQAFKIGVKFTCGTDAGTPFNGFERTPEEFGFLAKIGMTPAQAYQCSSINAATLMGIADDYGTLTVGKFADFQVLRADPLADTAAVIQADKAVYVGGVRQF
>NZ_CP019750.1|WP_085762602.1|18156_19758_-|peptide-ABC-transporter-substrate-binding-protein
MRRFVSLIPITLLLLAGLSACGSKTSANQNKTLNVTLADEPATVDPNKDTDTNSASVIAQTMEGLYTYSKSNKIIPGVATKVVKPTNHGKTYTFTLKKTAKWANGQRVTAQDFVTSLRRMADPTTKAQYASVLSAFKNYNAVQHGKLAPSKLGITALSKTKLQIQLTKAVPYFNDLVASKYYPLNTAAVRKYGSKYGTNAARAMSNGPYKLVGWTGSNSTWRYVKNPHYWNAQNVKIHQIKVAVTKDSTTAANLFNAGKIQETTVSGEYVRANGNSKQLHTHLLGRMNLLYFNSKRQTTASENLRQAVSYAIDRNQLTNSVLKDGSKAALSAVPRGDQTNPQTGKDMASEVGNLLTYNVSTAKRYWQKYLKEIGKTKVTLSILTDDSDDDKKVGTYLQSVLEKNLPGLTITLTQIPHAQHVSRDFAGNFDINLIGWSTNWLDASDYLDLAAKGNSVNFTNWNDQTYNQILTSAENQSGQARYNGLVKADKYLMRVKGYVPLYQPSEAKLISKQVGGLTYSLLNDAQYQYAYWK
>NZ_CP019750.1|WP_052471865.1|20313_20943_-|TetR/AcrR-family-transcriptional-regulator
MPLVNTVYLDYLRDNLKGVIFMRQDAQYNHQKILTTATHLLSTQDIATMKMTDIAHAAGIGVGTLYRNYPNKSALCLALVYDRLRVFITTTQAQIKQTTPTPATLKAVLTDYLAFRDANQALLNTISEVPQAGQDFYQSPLFQQLTDLFQKLLTPLHPDWSAQTIVFRSDMLVAMLKSEMYAFERQQRGLSNPDLLHELLSLLEVSPAD
>NZ_CP019750.1|WP_085763713.1|21023_21734_+|sulfite-exporter-TauE/SafE-family-protein
MIGVFVSLIGGGGASLYLGVLTSQLGLATAVAVPTSLFVALPALFLGFLTQVRIHNVNFKLGNQLLLTAIPGILAGALLAKYITAMLYNRIVGVILLVMGIIVVVKALRPGKQRDVRQSGWIASLFGLLSGLVVGIGGLSGGATTAAGLAILGLSALQAAGTATYVLWVMSAIGLAIHLITSTVDWSAGMGLMVGAIIGSIGTPLVLHRLNTERLNRWLMPFLGVIISYFGWRMLV
>NZ_CP019750.1|WP_080769713.1|21990_24006_+|DHH-family-phosphoesterase
MNKLFSRANVPEFLQNRRLRGIAMMTAGLAILGIVLAFLLNWIFGIVILILVGVATLMVFNTMAEIGADTTQYISDLSFRIQQGEQEALIRMPPGVMILGDSDQIEWVNPYLQHYFGDTDVLNRSLTAVDGELAKLIADAPAQTMTTVTWRDYRFTLYVQPDFHAVYLYDITHYQLIQEQYDNEKIAIGQIFLDNYDEITQSMTDQDISNLRNYVTNELSTWVQQFDMYLKQLDDDHYFILAYAKSLAAIEADKFKILDTIRESTSKQNFPLTLSMGIAYGDPNLNKLADQAQSNLDLALGRGGDQVVVKAADQEARYYGGKTNPMEKRTRVRARMISQALQELMNESDQIFVQGHSQPDMDSLGACLGIRRIAKMNNKTCWIVLDKETVHSDVQRLLDNLKQYPDIDAAIISPETALEKATDQSMLLMVDHSKPSISISADLYHRLENRVMIIDHHRRGEEFPENPLLVYIEPYASSTCELITEMFEYQSQEGEPINKLEATAMLTGIFVDTKHFSLRTGTRTFDAASYLRSAGADAVEMQQYMKENVDSYLQRNHLIEMVEFVNEDMALIVGEEDQSYDPVTAAQAADDLLNMSGVDASFVVTRRADGRVGISARSLGEINVQLTMEAMGGGGHLSNAATQIADKTVAEVRQQLLDILTHSDEPETATT

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Crispr_ID: NZ_CP019750_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019750_2

217436-218131

TypeII-A

Consensus_repeat	Method
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	PILER-CR
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CRISPRCasFinder
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CRT

10 spacers

csn2,cas2,cas1

The CRISPR arrays of NZ_CP019750_2

>merge|NZ_CP019750|2|217436-218131|PILER-CR,CRISPRCasFinder,CRT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACCCAAACGCTCCCCAATGAAGAGGCTCTGGGGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACCTATGCGGTTGATGGTGTGCTGTCAGTATCGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACTCATTCTTCCCCTCACGCTGATATCGCGTCGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACTTATCGGTGCAACCATTGCCGTCACAACTGGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACCCGTGTTTTGCCATTATTGGATAGTCAAATGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACATATTCGCTGTCGACATGCTATCAGGGACTGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACCACAATTTGAAAAAGATCTTAACGCGATGTGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACCACACAGGAACTTATGGACGCTTACGAGGGGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACATATCGTCCCGGTCTTCCCAGTTGCCATCTGCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAACATATTCTTCAATCGTATCGGCCCATGCTTTGCTTTAGAATCTTGGTAAATCAATAGGATCAAGAAT

>NZ_CP019750|2|1|217436-218130|PILER-CR
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CCCAAACGCTCCCCAATGAAGAGGCTCTGGG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CCTATGCGGTTGATGGTGTGCTGTCAGTATC
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CTCATTCTTCCCCTCACGCTGATATCGCGTC
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CTTATCGGTGCAACCATTGCCGTCACAACTG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CCCGTGTTTTGCCATTATTGGATAGTCAAAT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CATATTCGCTGTCGACATGCTATCAGGGACT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CCACAATTTGAAAAAGATCTTAACGCGATGT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CCACACAGGAACTTATGGACGCTTACGAGGG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CATATCGTCCCGGTCTTCCCAGTTGCCATCT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAA	CATATTCTTCAATCGTATCGGCCCATGCTTT
GCTTTAGAATCTTGGTAAATCAATAGGATCAAGAA

>NZ_CP019750|2|2|217436-218131|CRISPRCasFinder
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CCAAACGCTCCCCAATGAAGAGGCTCTGGG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CTATGCGGTTGATGGTGTGCTGTCAGTATC
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	TCATTCTTCCCCTCACGCTGATATCGCGTC
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	TTATCGGTGCAACCATTGCCGTCACAACTG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CCGTGTTTTGCCATTATTGGATAGTCAAAT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	ATATTCGCTGTCGACATGCTATCAGGGACT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CACAATTTGAAAAAGATCTTAACGCGATGT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CACACAGGAACTTATGGACGCTTACGAGGG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	ATATCGTCCCGGTCTTCCCAGTTGCCATCT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	ATATTCTTCAATCGTATCGGCCCATGCTTT
GCTTTAGAATCTTGGTAAATCAATAGGATCAAGAAT

>NZ_CP019750|2|1|217436-218131|CRT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CCAAACGCTCCCCAATGAAGAGGCTCTGGG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CTATGCGGTTGATGGTGTGCTGTCAGTATC
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	TCATTCTTCCCCTCACGCTGATATCGCGTC
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	TTATCGGTGCAACCATTGCCGTCACAACTG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CCGTGTTTTGCCATTATTGGATAGTCAAAT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	ATATTCGCTGTCGACATGCTATCAGGGACT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CACAATTTGAAAAAGATCTTAACGCGATGT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	CACACAGGAACTTATGGACGCTTACGAGGG
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	ATATCGTCCCGGTCTTCCCAGTTGCCATCT
GCTTTAGAATCTTGGTAAATCAATAGGGTTAAGAAC	ATATTCTTCAATCGTATCGGCCCATGCTTT
GCTTTAGAATCTTGGTAAATCAATAGGATCAAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019750.1\|WP_085762713.1\|225869_226400_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP019750.1\|WP_015474491.1\|228955_229957_+\|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176196
NZ_CP019750.1\|WP_085762706.1\|203363_205037_-\|alpha-glucosidase	unknown	unknown	gnl\|CDD\|200472
NZ_CP019750.1\|WP_085762712.1\|221284_223522_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NZ_CP019750.1\|WP_085762709.1\|209062_210706_-\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869
NZ_CP019750.1\|WP_043022289.1\|218785_220165_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340890
NZ_CP019750.1\|WP_024526177.1\|228062_228938_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|366120
NZ_CP019750.1\|WP_065200958.1\|206634_207633_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP019750.1\|WP_011668743.1\|224962_225796_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP019750.1\|WP_085762707.1\|207867_208356_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019750.1\|WP_085762705.1\|202642_203293_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019750.1\|WP_043022283.1\|226720_227047_-\|multidrug-resistance-protein-SMR	unknown	unknown	gnl\|CDD\|224987
NZ_CP019750.1\|WP_157128281.1\|224303_224702_+\|SdpI-family-protein	unknown	unknown	gnl\|CDD\|379303
NZ_CP019750.1\|WP_085762708.1\|208342_208873_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019750.1\|WP_085762714.1\|227285_227708_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019750.1\|WP_035464753.1\|205057_206440_-\|SLC45-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340871
NZ_CP019750.1\|WP_085762711.1\|216735_217401_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP019750.1\|WP_021741248.1\|226404_226719_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP019750.1\|WP_065200952.1\|216433_216739_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP019750.1\|WP_085762710.1\|215550_216456_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Function_ID	Function_description	E-value
NZ_CP019750.1\|WP_085762713.1\|225869_226400_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.64177e-18
NZ_CP019750.1\|WP_085762706.1\|203363_205037_-\|alpha-glucosidase	gnl\|CDD\|200472	cd11333, AmyAc_SI_OligoGlu_DGase, Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins. The sucrose isomerases (SIs) Isomaltulose synthase (EC 5.4.99.11) and Trehalose synthase (EC 5.4.99.16) catalyze the isomerization of sucrose and maltose to produce isomaltulose and trehalulose, respectively. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Dextran glucosidase (DGase, EC 3.2.1.70) hydrolyzes alpha-1,6-glucosidic linkages at the non-reducing end of panose, isomaltooligosaccharides and dextran to produce alpha-glucose.The common reaction chemistry of the alpha-amylase family enzymes is based on a two-step acid catalytic mechanism that requires two critical carboxylates: one acting as a general acid/base (Glu) and the other as a nucleophile (Asp). Both hydrolysis and transglycosylation proceed via the nucleophilic substitution reaction between the anomeric carbon, C1 and a nucleophile. Both enzymes contain the three catalytic residues (Asp, Glu and Asp) common to the alpha-amylase family as well as two histidine residues which are predicted to be critical to binding the glucose residue adjacent to the scissile bond in the substrates. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP019750.1\|WP_085762709.1\|209062_210706_-\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP019750.1\|WP_043022289.1\|218785_220165_+\|MFS-transporter	gnl\|CDD\|340890	cd17332, MFS_MelB_like, Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily. This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.86927e-107
NZ_CP019750.1\|WP_024526177.1\|228062_228938_+\|ROK-family-protein	gnl\|CDD\|366120	pfam00480, ROK, ROK family.	1.47909e-75
NZ_CP019750.1\|WP_065200958.1\|206634_207633_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.12578e-88
NZ_CP019750.1\|WP_011668743.1\|224962_225796_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	9.78691e-35
NZ_CP019750.1\|WP_015474491.1\|228955_229957_+\|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176196	cd08234, threonine_DH_like, L-threonine dehydrogenase. L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine, via NAD(H)-dependent oxidation. THD is a member of the zinc-requiring, medium chain NAD(H)-dependent alcohol dehydrogenase family (MDR). MDRs have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose.	2.69489e-175
NZ_CP019750.1\|WP_085762712.1\|221284_223522_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	3.10414e-148
NZ_CP019750.1\|WP_043022283.1\|226720_227047_-\|multidrug-resistance-protein-SMR	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	1.56343e-21
NZ_CP019750.1\|WP_035464753.1\|205057_206440_-\|SLC45-family-MFS-transporter	gnl\|CDD\|340871	cd17313, MFS_SLC45_SUC, Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters. This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.21066e-118
NZ_CP019750.1\|WP_157128281.1\|224303_224702_+\|SdpI-family-protein	gnl\|CDD\|379303	pfam13630, SdpI, SdpI/YfhL protein family. This family of proteins includes the SdpI and YfhL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein.	6.08913e-08
NZ_CP019750.1\|WP_085762711.1\|216735_217401_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.20021e-61
NZ_CP019750.1\|WP_021741248.1\|226404_226719_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	4.18465e-25
NZ_CP019750.1\|WP_065200952.1\|216433_216739_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.90838e-22
NZ_CP019750.1\|WP_085762710.1\|215550_216456_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.91715e-92

>NZ_CP019750.1|WP_085762711.1|216735_217401_+|type-II-A-CRISPR-associated-protein-Csn2
MNLTYYGFRPFKITPGKVVVLATGSPHIYQEIILGLQDRTDTVKLSDDNFTTVTVGKGAQWYGDPLLNVDLNALFKRKLQTRLLKVLADDQTVGLVDGLQSLLSQLLADSYLMDVPLELPETPELAKLIKFSGIQLVPDLRDDVYGILETLVKTLIELNDHRMVVLTNVGHYLQVSQLQSLVRFMANIDLPILLIEFSSTKQSDYFRNCDYHYIDSDFVLW
>NZ_CP019750.1|WP_065200952.1|216433_216739_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPMETSQDRRHYRHFRKALLQEGFFMMQYSVYVRVCPNSAGAAAIEKRIAALAPANGLVQSVMLTEKQYQAMHFIAGQPNQDLLNSAERTVMI
>NZ_CP019750.1|WP_085762710.1|215550_216456_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTLLISQHAKISLTSGNLVIQTDSDRYHTPVRDINVLLIQSLQVVITTAAVAALAEAHAKIIFTGRDGQPICETAECYPHARTAALVRQQVGWSEGRIENLWTRVVAAKIQNQIAVGNLLEVSTMDLSGELEKLELNDATNREAVVARQYFPLIFGKDFSRSDLVPINAALNYGYSILLSLVNRIIVSRGYLTCFGIHHDNAGNAFNLASDLMEPFRPIIDYWVAQQNILDLTPDVKFGLARLFELEMRYNGKQEVLSNVVEKVIVQCLKYLSEETETIRIEVDVPDEVSNYAINDYV
>NZ_CP019750.1|WP_085762709.1|209062_210706_-|peptide-ABC-transporter-substrate-binding-protein
MQRKGTILTVAALSLLTLAGCGSRSSSSNNSGKYAAKQVLNWTESSELATTDLAQATDTLSFNVLQNTQEGLYRLNSKGTPAKALATSTKVTNGGKTYTFNLRHGVKWSNGDPVTAKDFVYSWQRTVSPKTASQDAFYLYQVKNAEAVNKGKKSLSALGIKATGKYTLTVNLTKPVSYFKKLLAWPLFYPVNQNAVNKYGKKYGTSSSTTVYNGPYRLTKWNGTSKSWTLAKNKTYWDKKAVHLTKINEQVTESTTTSYNLYNAKKVDETLLSGQQIKNNKNSKDFVKRLPTGSQRLDLNEKKVSAFKNVNIRKALSLAINRTQLVNDVLQDGSVASKGFVPSGMGNNPKTGEAFNQEASVKSAVSYNVKQAKTLLAKGLKQAGDKKLNVTLSVSDTDSSKQTAEFIQSSLEKLPNVTVTIKTVPYVQLITQQNNGNYELTLAGWQSVFADPINFLDVFEADSSYNTTGWKNSTYDKLLDEAENVYGNQPEKRWGKLVAAEQVLMKNQGTIPLYQAAKSQLLRSNVKSVVYNPAGVPYDWKTTYIAK
>NZ_CP019750.1|WP_085762708.1|208342_208873_+|hypothetical-protein
MSCIKRSGDTMKKGLKGIVLAAASLGVFAMASSTTANAASKTTLPKSYRGTWYIYGGSDTEDKITAYAVAKLNLTNKKMGYKVYTTTKKQLTSLKWQLSAAFPTIYSKKVNNKKKVTYRVKARIDDSVTLMTLGKTKVNVKVLGKKVTALRLRVDGTNVYAFRKPLRTHALSDITY
>NZ_CP019750.1|WP_085762707.1|207867_208356_+|hypothetical-protein
MRKQLLVGVITGLAAFTLAGMGHETAQAATLPADYQGDWVAYVGKTKHHHVNYYYTARLTLADTSLATQLNVTKNANLSDLTTQVTLQSAVTYQLKTTKKHQVSYKVRMATDNASLGKFSLSKVKVKGQKTTALAFDDGEDDVVYAFRSLNKTHAWGDDVLY
>NZ_CP019750.1|WP_065200958.1|206634_207633_+|LacI-family-DNA-binding-transcriptional-regulator
MAATIKDIAKLAGVSPATVSRVLANKTAFFSADTAAKVQTAATTLGYQKNTAAAELVTQQSHVIAAIVNSTKTNFANHIIEGIQDAAYRQGLNVIILYAGDADPEQQRRALTTVIERPVRGILLLSVDLSADNLTYLQAAQIPYCFLSISFEEDQLPFITSDDWQVGYQGTQALLAQGHRQIGLAAVDSVHAHTGKLRLAGYTQALTEAGITPDPAWIQPGDYSYVAGQAAMRAYGQAPQVTAVLAGSDMAAIGVLNQARDFGLTVPHDLSIMAIDGTELCELVQPQLSSVSQSFYDMGVAGVEQLTTAQQQPPKITPITVVTRESVRFIES
>NZ_CP019750.1|WP_035464753.1|205057_206440_-|SLC45-family-MFS-transporter
MAQTTPIESTDATPAATSHNALPKISLKTIFAMTFGFFGVNMAFSLQSSQMGRIFQTIGADPTKLGFFFLLPPLAGMIVQPLVGKYSDMTWNRFGRRMPYLLIGAPIAALVMILLPNAGSFGFGYASLAALWFGAVAILFMDLSSNVCMQPFKMIIGDMVNEDQKDLAWSWQQSFSNLGGVLATIFPFVLTWFGVSNVAPKGTVPMSVRLAFYIGAGILLLTSLYTIISVKEYDPETYNRYHHVKTQAKQKTASLWHLVKTAPRAFWEVSFVQLFDWFAFQYLWTYGTGAIAANVWHTADASSAGYQAAGNWFGILSCIQALAAVVWGFAVLSRTKPAQRKLWFRISLIMGGAGFIWIFFIHSQYLLILPFCLIGICYLTMQTQALSLFTESLNGENEGAYLGLFNCGICLPQIIASLLSFAIFPAIGQSMPGMLVIAGVALLLGAVAVSVIHPKLSANL
>NZ_CP019750.1|WP_085762706.1|203363_205037_-|alpha-glucosidase
MTKKWWQNAVVYQVYPRSYQDSNGDGIGDLAGLTQRLPYIKRLGADVIWLNPIYKSPDKDNGYDISDYQSIQPAYGTMADFDHLLDSAHRQGLKLLMDLVVNHTSDQHDWFQQSRQSKDNPYADYYIWRDPVDGHEPNNWGSYFSGSAWTFEPKRNQYYLHLFAPGQPDLNWENPQVRQEVWNLMRFWLDKGVDGFRMDVINLISKPAGLPDAPQAPGAAYGDSQPIVSDGPKLNDYLREMNDEVLSHYDVMTVGEMPGSTPEDAITYTGLNANELNMVFQFEHVGLSPNPDARLGKWNAVPVKLTELKDSLSRWQTALDGKGWNSLYWNNHDQPRAVSRFGNDTPEFRERSAKMLATTLHMMQGTPYVYEGEELGMTNVHYTQLDQYEDLESLNAYHELVDDQHIVDQPTMLKYLSHISRDNARTPMHWDDSTNAGFTTGQPWFALNPNYPTINAADQLDQDDSVFNYYRRLIALRHSSDLIVLGSYEELDPEDDQVFAYKRHYQGQTLLVMSNFTDQTVTRDYGQAEASERLIGNYADDQGTTLRPYETKVYVFK
>NZ_CP019750.1|WP_085762705.1|202642_203293_+|hypothetical-protein
MRQFNSQLAGADFVPLGEWTPQPQTLLSAFSWEARDLLVVDDATDEMQIIAQADPAQLLDRLGGTIYSRLNDQLTRALVPRPLPAARYLLLDLAMLSHATPQATVAGLMGLAVVTAKGQAFTSTALPGVVSQAVCWLRETGLTEHQLFQPIGEATLRRLYQQLSHQSAACDQQRRCHTRAEKLTHDTVALLQGQIQTLKLPVSWQLLRAASLEQTI
>NZ_CP019750.1|WP_043022289.1|218785_220165_+|MFS-transporter
MSKMQLWKQRFFYGATDMAGNLIWQIVGLYLLFYYTTVMGISPAFAGTLFFVVRIIDAFDGVVYGFLIDHTHSKFGKARPYFLWFGIPLGILTMLLFFNPSFGGNKVIQLAWVSVVYTLFSLVYSGANTPITAILPSLTKDPDERTNLASARMVMTNIGTAVIGAITLPMVAQLGGKNAEKGWLIWGVIIGIAIIALFLGAFANLREKDDIVAETEDAPEIKGHLSVKDSLKGAAKNKPWLILSASFILLQTFWMMRLQTAVYYLTYVSHQPALVGAFNGLVIVAVIGNISVPFLSKFMKHRNVMILAMVTFAFGELLMAFKNIPLLFIGNVIALVAMGAAFSIAFVMIADTVEYSRSELHIDEPGILSAVPMVGAKLGMGLAGLISGWLLSWGGFNAAAKVQGAKAVTAIATNFIWVPVVLALVIGGILYLWYQLDESKIASAKAAKEAEKKLSEEDA
>NZ_CP019750.1|WP_085762712.1|221284_223522_+|glycoside-hydrolase-family-65-protein
MQIRQLGEIMLTLQDYHLTLHDVANHQPAYLETVFSLANGHFGVRANDPITGNPIAGTLINGFYETAPITYGEAGVGYAKAHQTILNLPDFRHINVATTTGHSFTSSERTKVDLDLATGELTEHYTLQTRQGETIAMSVQSVIGQTQTAFWAVNYGFLAGNYAGGLVVNKTIAVPAEAESLPSADPRKTRLAGLPICETTFMAKDLQQYHVKTRQTKQSVTIYLGMLTTPGSLLRQPVDLGDHTTHHLSYEVYVGEMGQQNTIDPALPFPATALTALMTDSRDFWQDVWQRSEVTVGGNDELDLAIHYNLFQLNQAAGRDGRTNIAAKGLSGSGYEGHYFWDTEMYMLPYFIYTNQPMARQLLVYRYQTLPQARQRARALGVDQGALFAWRTINGEEASAYFPAGTAQYHIDADIAYAVGKYYEITRDIDFIKQCGFEMVLETAHFWEAFGSWHQVGTSQRFEFHTVTGPDEYTALVNNNYYTNRLAKHNFELVTYLAQEILKVDPNGLTKFGIDATDIDAFQNLAEHVYLPYNAEQQINAQDDSFLSKPRWPVAQSTPENFPLLLHYHPLTIYRYQVAKQADTLLADYLFPEDLSPEQLQREYHYYEGVTTHDSSLSRSIFSILAARMGDVEKGYRYFMDTAQMDLVNLQKNTADGLHLANLGGSWLALVAGFSGFYVQDEVVHFTNHLPSELTQLTYRMKIAESVLEIKLTATETTVVVISGPIPTYGVSVNGQLISLAKKVR
>NZ_CP019750.1|WP_157128281.1|224303_224702_+|SdpI-family-protein
MVNRRHRGLKISLDLNVVFGSYCLILVLLPLAYANTAIVGHLTGVGIIVSLIGVPMSYVPQNRLLYGIRIPASKNSPAVWQKTNHLAARICFGFGGLIFLLGLLGQAAFVLTMAVGAVVLVVSTSLYARKLS
>NZ_CP019750.1|WP_011668743.1|224962_225796_+|histidine-phosphatase-family-protein
MKLTKVVSLLAVTAGALALVAVPSNAQAKTKKKAAVKPVTIYLTRHGETTGNVMGRVQGWSDFPLTSNGIAVANNLGRGLKGKTFKVAYAGNLTRQQVTAKQALKYSGNKKVKVNVSKYLREGGYGSFEGDSIAADNALIAGVYGFKSGDEMMAKQGKDYWNLLQDAYYKLDQENSQKTNLVASDRAESSKQVQKRMAKELLTIAKATQKRGGGNALVVSSGMSINEYLSTMAGSKYTGAPLKNAAVTKLVYKHGKLAVSGPIGSMTYVDKGAKLAK
>NZ_CP019750.1|WP_085762713.1|225869_226400_+|GNAT-family-N-acetyltransferase
MAVRLKPLASEEVAAFWQLAFRDPQAEWTQWNGPYFHDHVPTYAEFVTGPGHEDYVDQPWRQVIWVDGQMVGMVSAYYDDAPLNRWLDVGIIIYDQHRWQRGIGRTTLSQWIDWLWTQTPLPHIGLTTWSGNQRMCHLAESLGLREEARVRQVRYWQGRYWDSVKYGVLREEWHKR
>NZ_CP019750.1|WP_021741248.1|226404_226719_-|multidrug-efflux-SMR-transporter
MAWLFLIGAGLSEMLGVTFMNWALHRKTWWLWVLMILAFTLSFGGLELALKTLPMGTAYAIWTGIGAAGGVLTGMLFFGESKDWRKLVWVAVILSATLGLKLIS
>NZ_CP019750.1|WP_043022283.1|226720_227047_-|multidrug-resistance-protein-SMR
MWRHWLTVVLGAVFEVSWVVGFKHATTLWAWLITGVAVYLSFYFLIRASRSIPAGTAYAVFVGLGTLGTTSVGMFVFGEPISWLKIALILLLLAGIGGLQWTTTKEAN
>NZ_CP019750.1|WP_085762714.1|227285_227708_-|hypothetical-protein
MQRKYRDYFAYLKTINPDPNASFIAVSPSNVQKTDPDKFATLTARAGRRWGVILFHALYGNKTTKKTKVPYAVVHEDSFARDWDGIDRAEFDEDVAILVQCQMLQVKEVQGLTRLIMRYPEPLASLADLRIKGIDQINPG
>NZ_CP019750.1|WP_024526177.1|228062_228938_+|ROK-family-protein
MQLGSIEAGGTKFVCAIGNEDYRTQDKVRIPTTTPEETLSQTIAYFKQFPDLKAIAISSFGPIELRHNSPKYGYITNTPKVGWANTDFVGRLKQELDVPMYWTSDVNGSAYGEYVMSTLFNENINSLVYFTIGTGVGAGAIIDGHFVGSLGHPEMGHVRLKRHPDDLDFPGICPFHGDCLEGLVSGPTFDARLGKPGKDVPLTDHVWDILAYYVAQAALQVTLMMRPDKIVFGGGVVSEAFLDKVRHEFDQLLNHYVDVGKLTDYIVMPAVKDNGSATLGDFALALNEYNK
>NZ_CP019750.1|WP_015474491.1|228955_229957_+|zinc-dependent-alcohol-dehydrogenase-family-protein
MKALVLTGTKQFEMQDVTTPTVKDDEVLVNTAYAGICGTDRALYAGLPGSADAVPPIVLGHENSGIVAAIGRNVTNVKVGDRVTVDPNIYCGECEYCRTDRPELCDNLSAVGVTRDGGLEESFTAPASVVYPIPDSVSLKAAATVEPISCAVHGVKLLDLTPYQKALVIGDGFMGQLFVQLLQAYGVHQVDFAGIVDEKLAFNKEKFGVTNTYNTTRDSIPADYDVVIEAVGLPQTQEQAVEATKKGAQVLMFGVGKPNQTFSMNTYEVYQKQLKIQGAFINPYAFEDAIALLASGQLDVESLISHEVSLEQVEDVLNGKVEHVSKAVVKVSD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP019750_2	2.12\|217538\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217538-217567	30	MN830254	Lactobacillus phage JNU_P2, complete genome	3717-3746	1	0.967
NZ_CP019750_2	2.12\|217538\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217538-217567	30	MN830255	Lactobacillus phage JNU_P4, complete genome	39261-39290	1	0.967
NZ_CP019750_2	2.20\|218066\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	218066-218095	30	MK504446	Lactobacillus phage SAC12B, complete genome	117378-117407	1	0.967
NZ_CP019750_2	2.20\|218066\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	218066-218095	30	MN830254	Lactobacillus phage JNU_P2, complete genome	43134-43163	1	0.967
NZ_CP019750_2	2.20\|218066\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	218066-218095	30	MN830255	Lactobacillus phage JNU_P4, complete genome	29657-29686	1	0.967
NZ_CP019750_2	2.2\|217537\|31\|NZ_CP019750\|PILER-CR	217537-217567	31	MN830254	Lactobacillus phage JNU_P2, complete genome	3716-3746	2	0.935
NZ_CP019750_2	2.2\|217537\|31\|NZ_CP019750\|PILER-CR	217537-217567	31	MN830255	Lactobacillus phage JNU_P4, complete genome	39260-39290	2	0.935
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	MK504446	Lactobacillus phage SAC12B, complete genome	117378-117408	2	0.935
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	MN830254	Lactobacillus phage JNU_P2, complete genome	43134-43164	2	0.935
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	MN830255	Lactobacillus phage JNU_P4, complete genome	29657-29687	2	0.935
NZ_CP019750_2	2.7\|217867\|31\|NZ_CP019750\|PILER-CR	217867-217897	31	NC_013384	Staphylococcus epidermidis plasmid SAP110B, complete sequence	355-385	6	0.806
NZ_CP019750_2	2.11\|217472\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217472-217501	30	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	646916-646945	6	0.8
NZ_CP019750_2	2.17\|217868\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217868-217897	30	NC_013384	Staphylococcus epidermidis plasmid SAP110B, complete sequence	356-385	6	0.8
NZ_CP019750_2	2.1\|217471\|31\|NZ_CP019750\|PILER-CR	217471-217501	31	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	646915-646945	7	0.774
NZ_CP019750_2	2.14\|217670\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217670-217699	30	NZ_CP042264	Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence	165551-165580	7	0.767
NZ_CP019750_2	2.17\|217868\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217868-217897	30	NC_004528	Leuconostoc citreum pLC22R plasmid, complete genome	2593-2622	7	0.767
NZ_CP019750_2	2.1\|217471\|31\|NZ_CP019750\|PILER-CR	217471-217501	31	NZ_CP041766	Tomitella sp. HY188 plasmid unnamed, complete sequence	18561-18591	8	0.742
NZ_CP019750_2	2.4\|217669\|31\|NZ_CP019750\|PILER-CR	217669-217699	31	NZ_CP042264	Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence	165550-165580	8	0.742
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	NZ_CP015065	Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence	184884-184914	8	0.742
NZ_CP019750_2	2.11\|217472\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217472-217501	30	NZ_CP041766	Tomitella sp. HY188 plasmid unnamed, complete sequence	18561-18590	8	0.733
NZ_CP019750_2	2.14\|217670\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217670-217699	30	NZ_CP042264	Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence	166487-166516	8	0.733
NZ_CP019750_2	2.14\|217670\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217670-217699	30	MG969414	UNVERIFIED: Salmonella phage GE_vB_NS7, complete genome	44307-44336	8	0.733
NZ_CP019750_2	2.14\|217670\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	217670-217699	30	MK574078	Pseudomonas phage KP1, complete sequence	37487-37516	8	0.733
NZ_CP019750_2	2.19\|218000\|30\|NZ_CP019750\|CRISPRCasFinder,CRT	218000-218029	30	NC_047962	Xanthomonas phage Carpasina, complete genome	9906-9935	8	0.733
NZ_CP019750_2	2.4\|217669\|31\|NZ_CP019750\|PILER-CR	217669-217699	31	NZ_CP042264	Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence	166486-166516	9	0.71
NZ_CP019750_2	2.4\|217669\|31\|NZ_CP019750\|PILER-CR	217669-217699	31	MG969414	UNVERIFIED: Salmonella phage GE_vB_NS7, complete genome	44307-44337	9	0.71
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	NC_014918	Mesorhizobium ciceri biovar biserrulae WSM1271 plasmid pMESCI01, complete sequence	335554-335584	9	0.71
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	NZ_CP021071	Mesorhizobium sp. WSM1497 plasmid pWSM1497, complete sequence	154551-154581	9	0.71
NZ_CP019750_2	2.10\|218065\|31\|NZ_CP019750\|PILER-CR	218065-218095	31	NZ_CP015063	Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence	202590-202620	9	0.71

1. spacer 2.12|217538|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MN830254 (Lactobacillus phage JNU_P2, complete genome) position: , mismatch: 1, identity: 0.967

ctatgcggttgatggtgtgctgtcagtatc	CRISPR spacer
ctatgcggttgatggtgtgttgtcagtatc	Protospacer
*******************.**********

2. spacer 2.12|217538|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MN830255 (Lactobacillus phage JNU_P4, complete genome) position: , mismatch: 1, identity: 0.967

ctatgcggttgatggtgtgctgtcagtatc	CRISPR spacer
ctatgcggttgatggtgtgttgtcagtatc	Protospacer
*******************.**********

3. spacer 2.20|218066|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MK504446 (Lactobacillus phage SAC12B, complete genome) position: , mismatch: 1, identity: 0.967

atattcttcaatcgtatcggcccatgcttt	CRISPR spacer
atattcttcaatcgtatcggcccttgcttt	Protospacer
*********************** ******

4. spacer 2.20|218066|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MN830254 (Lactobacillus phage JNU_P2, complete genome) position: , mismatch: 1, identity: 0.967

atattcttcaatcgtatcggcccatgcttt	CRISPR spacer
atattcttcaatcgtatcggcccatacttt	Protospacer
*************************.****

5. spacer 2.20|218066|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MN830255 (Lactobacillus phage JNU_P4, complete genome) position: , mismatch: 1, identity: 0.967

atattcttcaatcgtatcggcccatgcttt	CRISPR spacer
atattcttcaatcgtatcggcccatacttt	Protospacer
*************************.****

6. spacer 2.2|217537|31|NZ_CP019750|PILER-CR matches to MN830254 (Lactobacillus phage JNU_P2, complete genome) position: , mismatch: 2, identity: 0.935

cctatgcggttgatggtgtgctgtcagtatc	CRISPR spacer
actatgcggttgatggtgtgttgtcagtatc	Protospacer
 *******************.**********

7. spacer 2.2|217537|31|NZ_CP019750|PILER-CR matches to MN830255 (Lactobacillus phage JNU_P4, complete genome) position: , mismatch: 2, identity: 0.935

cctatgcggttgatggtgtgctgtcagtatc	CRISPR spacer
actatgcggttgatggtgtgttgtcagtatc	Protospacer
 *******************.**********

8. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to MK504446 (Lactobacillus phage SAC12B, complete genome) position: , mismatch: 2, identity: 0.935

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
tatattcttcaatcgtatcggcccttgcttt	Protospacer
.*********************** ******

9. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to MN830254 (Lactobacillus phage JNU_P2, complete genome) position: , mismatch: 2, identity: 0.935

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
tatattcttcaatcgtatcggcccatacttt	Protospacer
.*************************.****

10. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to MN830255 (Lactobacillus phage JNU_P4, complete genome) position: , mismatch: 2, identity: 0.935

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
tatattcttcaatcgtatcggcccatacttt	Protospacer
.*************************.****

11. spacer 2.7|217867|31|NZ_CP019750|PILER-CR matches to NC_013384 (Staphylococcus epidermidis plasmid SAP110B, complete sequence) position: , mismatch: 6, identity: 0.806

ccacaatttgaaaaagatcttaacgcgatgt	CRISPR spacer
ccacaattagaaaaagatcttaaagagcttc	Protospacer
******** ************** * * * .

12. spacer 2.11|217472|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 6, identity: 0.8

ccaaacgctccccaatgaagaggctctggg	CRISPR spacer
tcaatttctcccgaaggaagaggctctggg	Protospacer
.*** . ***** ** **************

13. spacer 2.17|217868|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NC_013384 (Staphylococcus epidermidis plasmid SAP110B, complete sequence) position: , mismatch: 6, identity: 0.8

cacaatttgaaaaagatcttaacgcgatgt	CRISPR spacer
cacaattagaaaaagatcttaaagagcttc	Protospacer
******* ************** * * * .

14. spacer 2.1|217471|31|NZ_CP019750|PILER-CR matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 7, identity: 0.774

cccaaacgctccccaatgaagaggctctggg	CRISPR spacer
gtcaatttctcccgaaggaagaggctctggg	Protospacer
 .*** . ***** ** **************

15. spacer 2.14|217670|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NZ_CP042264 (Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.767

ttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
gtatcggtgccgccattgccgtcatcgatg	Protospacer
 ********* .************. . **

16. spacer 2.17|217868|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NC_004528 (Leuconostoc citreum pLC22R plasmid, complete genome) position: , mismatch: 7, identity: 0.767

cacaatttgaaaaagatctta---acgcgatgt	CRISPR spacer
cacaatttgaaaaagatattacacgagcaa---	Protospacer
***************** ***   . **.*

17. spacer 2.1|217471|31|NZ_CP019750|PILER-CR matches to NZ_CP041766 (Tomitella sp. HY188 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cccaaa---cgctccccaatgaagaggctctggg	CRISPR spacer
---aggttccgctccccgatgaagaggttctgcg	Protospacer
   *..   ********.*********.**** *

18. spacer 2.4|217669|31|NZ_CP019750|PILER-CR matches to NZ_CP042264 (Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.742

cttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
ggtatcggtgccgccattgccgtcatcgatg	Protospacer
  ********* .************. . **

19. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to NZ_CP015065 (Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence) position: , mismatch: 8, identity: 0.742

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
catagtcttcaagcgtatcggccagttgctc	Protospacer
**** ******* ********** .*  .*.

20. spacer 2.11|217472|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NZ_CP041766 (Tomitella sp. HY188 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ccaaacgctccccaatgaagaggctctggg	CRISPR spacer
ggttccgctccccgatgaagaggttctgcg	Protospacer
     ********.*********.**** *

21. spacer 2.14|217670|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NZ_CP042264 (Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.733

ttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
atatcggtgccgccattgccgtcatcgacg	Protospacer
 ********* .************. . .*

22. spacer 2.14|217670|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MG969414 (UNVERIFIED: Salmonella phage GE_vB_NS7, complete genome) position: , mismatch: 8, identity: 0.733

ttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
ctccaagtgcaaccattgctttcacaactc	Protospacer
.* . .*************. ********

23. spacer 2.14|217670|30|NZ_CP019750|CRISPRCasFinder,CRT matches to MK574078 (Pseudomonas phage KP1, complete sequence) position: , mismatch: 8, identity: 0.733

ttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
aaattattgcaactattgccgtcacaacga	Protospacer
  **.. ******.************** .

24. spacer 2.19|218000|30|NZ_CP019750|CRISPRCasFinder,CRT matches to NC_047962 (Xanthomonas phage Carpasina, complete genome) position: , mismatch: 8, identity: 0.733

atatcgtcccggtcttcccagttgccatct	CRISPR spacer
acgatttcctggtcttcccagttgccaacc	Protospacer
*.. . ***.***************** *.

25. spacer 2.4|217669|31|NZ_CP019750|PILER-CR matches to NZ_CP042264 (Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.71

cttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
gatatcggtgccgccattgccgtcatcgacg	Protospacer
  ********* .************. . .*

26. spacer 2.4|217669|31|NZ_CP019750|PILER-CR matches to MG969414 (UNVERIFIED: Salmonella phage GE_vB_NS7, complete genome) position: , mismatch: 9, identity: 0.71

cttatcggtgcaaccattgccgtcacaactg	CRISPR spacer
tctccaagtgcaaccattgctttcacaactc	Protospacer
..* . .*************. ********

27. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to NC_014918 (Mesorhizobium ciceri biovar biserrulae WSM1271 plasmid pMESCI01, complete sequence) position: , mismatch: 9, identity: 0.71

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
catagtcttcaagcgtatcggccagctgctc	Protospacer
**** ******* ********** ..  .*.

28. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to NZ_CP021071 (Mesorhizobium sp. WSM1497 plasmid pWSM1497, complete sequence) position: , mismatch: 9, identity: 0.71

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
catagtcttcaagcgtatcggccagctgctc	Protospacer
**** ******* ********** ..  .*.

29. spacer 2.10|218065|31|NZ_CP019750|PILER-CR matches to NZ_CP015063 (Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence) position: , mismatch: 9, identity: 0.71

catattcttcaatcgtatcggcccatgcttt	CRISPR spacer
catagtcttcaagcgtatcggccagctgctc	Protospacer
**** ******* ********** ..  .*.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

870913 : 995836

159

Lactobacillus_phage(80.81%)

terminase,protease,integrase,plate,capsid,tail,transposase

attL 870691:870711|attR 991467:991487

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
870691:870711	attL	NA	NA	NA	NA
WP_191981936.1\|870913_872113_-\|integrase	site-specific integrase	D6PSS4	Lactobacillus_phage	1.3e-142	64.1
WP_085763003.1\|872544_873426_-	type II toxin-antitoxin system PemK/MazF family toxin	Q4ZE81	Staphylococcus_phage	4.1e-16	36.6
WP_085763004.1\|873544_873928_-	hypothetical protein	NA	NA	NA	NA
WP_085763005.1\|873981_874305_-	hypothetical protein	NA	NA	NA	NA
WP_155275714.1\|874415_874586_+	hypothetical protein	NA	NA	NA	NA
WP_052415627.1\|874597_875233_-	DUF4145 domain-containing protein	A0A1X9I6S1	Streptococcus_phage	8.7e-24	33.2
WP_085763729.1\|875243_875630_-	ImmA/IrrE family metallo-endopeptidase	D6PSS8	Lactobacillus_phage	1.3e-67	94.5
WP_085763006.1\|875658_876039_-	helix-turn-helix domain-containing protein	D6PSS9	Lactobacillus_phage	1.3e-22	53.1
WP_047021620.1\|876179_876407_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_085763007.1\|876676_876862_+	hypothetical protein	NA	NA	NA	NA
WP_085763008.1\|876850_877099_-	hypothetical protein	NA	NA	NA	NA
WP_157128259.1\|877255_877420_+	hypothetical protein	NA	NA	NA	NA
WP_085763009.1\|877480_877990_+	helix-turn-helix domain-containing protein	D6PST4	Lactobacillus_phage	1.3e-41	53.8
WP_085763010.1\|877994_878270_+	hypothetical protein	D6PST5	Lactobacillus_phage	9.8e-25	60.9
WP_157128260.1\|878275_878434_+	hypothetical protein	D6PST6	Lactobacillus_phage	3.3e-17	78.8
WP_085763011.1\|878543_878858_+	hypothetical protein	NA	NA	NA	NA
WP_085763012.1\|878857_879745_+	YqaJ viral recombinase family protein	A0A0P0IJW5	Lactobacillus_phage	1.7e-94	56.6
WP_085763013.1\|879747_880701_+	recombinase RecT	D2IYT9	Enterococcus_phage	4.9e-79	56.9
WP_085763014.1\|880729_881671_+	DUF4373 domain-containing protein	A0A0H4TKJ7	Bacillus_phage	3.8e-15	35.2
WP_085763015.1\|881667_882369_+	Rha family transcriptional regulator	D2IYT0	Enterococcus_phage	4.1e-51	46.6
WP_085763016.1\|882361_882781_+	RusA family crossover junction endodeoxyribonuclease	D6PSU4	Lactobacillus_phage	9.4e-43	59.0
WP_085763017.1\|882768_883032_+	hypothetical protein	NA	NA	NA	NA
WP_085763018.1\|883201_884005_+	DNA adenine methylase	Q24LC8	Clostridium_phage	3.2e-63	43.3
WP_085763019.1\|884107_884305_+	hypothetical protein	NA	NA	NA	NA
WP_024525425.1\|884297_884573_+	DUF3850 domain-containing protein	U5U430	Lactobacillus_phage	2.3e-18	61.8
WP_069359856.1\|884606_884909_+	hypothetical protein	NA	NA	NA	NA
WP_085763020.1\|884938_885259_+	hypothetical protein	NA	NA	NA	NA
WP_085763021.1\|885263_885461_+	hypothetical protein	NA	NA	NA	NA
WP_085763022.1\|885539_886013_+	hypothetical protein	U5U7A6	Lactobacillus_phage	3.9e-13	35.9
WP_084994700.1\|886877_887954_+	hypothetical protein	A0A1S5S8Z0	Streptococcus_phage	1.6e-06	34.5
WP_157128261.1\|888012_888189_+	hypothetical protein	NA	NA	NA	NA
WP_035464847.1\|888226_888442_-	CsbD family protein	NA	NA	NA	NA
WP_085763023.1\|888639_888873_+	hypothetical protein	D6PSW7	Lactobacillus_phage	1.1e-32	87.0
WP_085763024.1\|888931_889684_+	TerS	D6PSW8	Lactobacillus_phage	5.1e-108	90.3
WP_085763025.1\|889661_891005_+\|terminase	PBSX family phage terminase large subunit	D6PSX1	Lactobacillus_phage	7.9e-168	99.6
WP_085763026.1\|891021_892383_+	DUF1073 domain-containing protein	D6PSX2	Lactobacillus_phage	4.9e-258	97.8
WP_085763027.1\|892385_893213_+\|capsid	minor capsid protein	D6PSX3	Lactobacillus_phage	9.0e-130	96.7
WP_191981937.1\|893235_893505_+	LysM peptidoglycan-binding domain-containing protein	D6PSX4	Lactobacillus_phage	8.7e-18	86.5
WP_085763029.1\|893516_894620_+	DUF2213 domain-containing protein	D6PSX5	Lactobacillus_phage	1.6e-158	89.6
WP_042254689.1\|894634_895099_+	hypothetical protein	D6PSX6	Lactobacillus_phage	6.4e-77	98.7
WP_085763030.1\|895113_895992_+	encapsulin	D6PSX7	Lactobacillus_phage	6.8e-160	98.6
WP_085763031.1\|896002_896365_+	hypothetical protein	D6PSX8	Lactobacillus_phage	8.1e-59	99.2
WP_085763032.1\|896376_896703_+	DUF4054 domain-containing protein	D6PSX9	Lactobacillus_phage	3.9e-52	95.4
WP_085763033.1\|896699_897302_+	hypothetical protein	D6PSY0	Lactobacillus_phage	1.5e-97	87.9
WP_085763034.1\|897301_897676_+	hypothetical protein	D6PSY1	Lactobacillus_phage	5.9e-65	94.4
WP_085763035.1\|897668_898139_+	hypothetical protein	D6PSY2	Lactobacillus_phage	4.2e-60	94.9
WP_085763036.1\|898151_899189_+	DUF3383 family protein	D6PSY3	Lactobacillus_phage	1.7e-141	95.1
WP_085763037.1\|899203_899602_+	hypothetical protein	D6PSY4	Lactobacillus_phage	3.1e-72	99.2
WP_085763038.1\|899672_900047_+	hypothetical protein	D6PSY5	Lactobacillus_phage	2.8e-62	91.1
WP_157128262.1\|900057_900228_+	hypothetical protein	D6PSY6	Lactobacillus_phage	9.7e-23	94.4
WP_085763039.1\|900242_905966_+\|tail	phage tail tape measure protein	D6PSY9	Lactobacillus_phage	1.1e-138	85.2
WP_085763040.1\|905965_906613_+	LysM peptidoglycan-binding domain-containing protein	D6PSZ4	Lactobacillus_phage	3.4e-108	92.1
WP_191981938.1\|906624_907017_+	hypothetical protein	D6PSZ5	Lactobacillus_phage	7.1e-69	100.0
WP_085763042.1\|907006_908248_+	hypothetical protein	D6PSZ6	Lactobacillus_phage	1.4e-206	90.8
WP_085763043.1\|908247_908592_+	hypothetical protein	D6PSZ7	Lactobacillus_phage	2.5e-57	97.4
WP_085763044.1\|908591_908990_+	hypothetical protein	D6PSZ8	Lactobacillus_phage	5.8e-50	80.2
WP_085763045.1\|908976_909744_+\|plate	baseplate J/gp47 family protein	D6PSZ9	Lactobacillus_phage	1.4e-89	81.0
WP_157128263.1\|909644_910154_+	hypothetical protein	D6PSZ9	Lactobacillus_phage	1.1e-72	79.9
WP_085763047.1\|910143_910803_+	hypothetical protein	D6PT00	Lactobacillus_phage	2.8e-73	82.4
WP_085763048.1\|910805_912701_+	hypothetical protein	A0A2K9VCK7	Lactobacillus_phage	3.6e-41	58.6
WP_085763049.1\|912712_913141_+	hypothetical protein	NA	NA	NA	NA
WP_157128264.1\|913152_913320_+	XkdX family protein	NA	NA	NA	NA
WP_085763730.1\|913423_913777_+	hypothetical protein	D6PSR9	Lactobacillus_phage	6.5e-37	67.3
WP_085763050.1\|913766_914150_+	hypothetical protein	NA	NA	NA	NA
WP_085763051.1\|914161_914680_+	hypothetical protein	D6PSS1	Lactobacillus_phage	8.2e-81	93.0
WP_157128265.1\|915809_916607_+	hypothetical protein	NA	NA	NA	NA
WP_085763053.1\|916614_917748_+	ImmA/IrrE family metallo-endopeptidase	A0A0U4JD08	Gordonia_phage	3.5e-23	26.4
WP_085763054.1\|918154_918361_-	DUF3923 family protein	NA	NA	NA	NA
WP_042521251.1\|918533_918911_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_085762957.1\|919328_920504_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_085763055.1\|920898_922080_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_191981936.1\|922555_923755_-\|integrase	site-specific integrase	D6PSS4	Lactobacillus_phage	1.3e-142	64.1
WP_085763003.1\|924186_925068_-	type II toxin-antitoxin system PemK/MazF family toxin	Q4ZE81	Staphylococcus_phage	4.1e-16	36.6
WP_085763004.1\|925186_925570_-	hypothetical protein	NA	NA	NA	NA
WP_085763005.1\|925623_925947_-	hypothetical protein	NA	NA	NA	NA
WP_155275714.1\|926057_926228_+	hypothetical protein	NA	NA	NA	NA
WP_052415627.1\|926239_926875_-	DUF4145 domain-containing protein	A0A1X9I6S1	Streptococcus_phage	8.7e-24	33.2
WP_085763729.1\|926885_927272_-	ImmA/IrrE family metallo-endopeptidase	D6PSS8	Lactobacillus_phage	1.3e-67	94.5
WP_085763006.1\|927300_927681_-	helix-turn-helix domain-containing protein	D6PSS9	Lactobacillus_phage	1.3e-22	53.1
WP_047021620.1\|927821_928049_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_085763007.1\|928318_928504_+	hypothetical protein	NA	NA	NA	NA
WP_085763008.1\|928492_928741_-	hypothetical protein	NA	NA	NA	NA
WP_157128259.1\|928897_929062_+	hypothetical protein	NA	NA	NA	NA
WP_085763009.1\|929122_929632_+	helix-turn-helix domain-containing protein	D6PST4	Lactobacillus_phage	1.3e-41	53.8
WP_085763010.1\|929636_929912_+	hypothetical protein	D6PST5	Lactobacillus_phage	9.8e-25	60.9
WP_157128260.1\|929917_930076_+	hypothetical protein	D6PST6	Lactobacillus_phage	3.3e-17	78.8
WP_085763011.1\|930185_930500_+	hypothetical protein	NA	NA	NA	NA
WP_085763012.1\|930499_931387_+	YqaJ viral recombinase family protein	A0A0P0IJW5	Lactobacillus_phage	1.7e-94	56.6
WP_085763056.1\|932393_933311_+	DUF4373 domain-containing protein	D6PSU3	Lactobacillus_phage	2.2e-12	73.7
WP_085763015.1\|933307_934009_+	Rha family transcriptional regulator	D2IYT0	Enterococcus_phage	4.1e-51	46.6
WP_085763016.1\|934001_934421_+	RusA family crossover junction endodeoxyribonuclease	D6PSU4	Lactobacillus_phage	9.4e-43	59.0
WP_085763057.1\|934408_934645_+	hypothetical protein	NA	NA	NA	NA
WP_085763019.1\|935745_935943_+	hypothetical protein	NA	NA	NA	NA
WP_024525425.1\|935935_936211_+	DUF3850 domain-containing protein	U5U430	Lactobacillus_phage	2.3e-18	61.8
WP_085763058.1\|936244_936487_+	hypothetical protein	NA	NA	NA	NA
WP_085763059.1\|936575_936836_+	hypothetical protein	NA	NA	NA	NA
WP_085763022.1\|937172_937646_+	hypothetical protein	U5U7A6	Lactobacillus_phage	3.9e-13	35.9
WP_085763061.1\|938617_939526_+	hypothetical protein	A0A1S5S8Z0	Streptococcus_phage	4.4e-05	36.0
WP_157128261.1\|939639_939816_+	hypothetical protein	NA	NA	NA	NA
WP_035464847.1\|939853_940069_-	CsbD family protein	NA	NA	NA	NA
WP_085763024.1\|940555_941308_+	TerS	D6PSW8	Lactobacillus_phage	5.1e-108	90.3
WP_085763062.1\|943268_943589_+	DUF1073 domain-containing protein	D6PSX2	Lactobacillus_phage	2.2e-31	81.5
WP_085763063.1\|944644_944935_+	hypothetical protein	D6PSX3	Lactobacillus_phage	1.5e-10	100.0
WP_085763064.1\|945217_945550_+	DUF2213 domain-containing protein	D6PSX5	Lactobacillus_phage	4.3e-43	91.9
WP_085763065.1\|945638_946010_+	hypothetical protein	D6PSX5	Lactobacillus_phage	4.9e-27	80.9
WP_085763066.1\|946244_946694_+	hypothetical protein	D6PSX6	Lactobacillus_phage	9.1e-28	89.5
WP_085763067.1\|946866_947457_+	encapsulin	D6PSX7	Lactobacillus_phage	3.7e-85	93.3
WP_191981939.1\|947732_947927_+	hypothetical protein	D6PSX8	Lactobacillus_phage	1.0e-20	98.1
WP_085763069.1\|947919_948105_+	hypothetical protein	D6PSX9	Lactobacillus_phage	1.9e-16	97.7
WP_191981940.1\|948070_948244_+	hypothetical protein	D6PSX9	Lactobacillus_phage	1.3e-22	94.6
WP_157128354.1\|948521_948764_+	hypothetical protein	D6PSY0	Lactobacillus_phage	6.9e-22	75.4
WP_085763070.1\|948836_949103_+	hypothetical protein	D6PSY1	Lactobacillus_phage	3.8e-42	98.8
WP_085763035.1\|949201_949672_+	hypothetical protein	D6PSY2	Lactobacillus_phage	4.2e-60	94.9
WP_085763071.1\|949684_950197_+	hypothetical protein	D6PSY3	Lactobacillus_phage	1.6e-65	91.5
WP_085763072.1\|950297_950720_+	DUF3383 family protein	D6PSY3	Lactobacillus_phage	1.1e-27	96.7
WP_085763037.1\|950734_951133_+	hypothetical protein	D6PSY4	Lactobacillus_phage	3.1e-72	99.2
WP_085763073.1\|951203_951383_+	hypothetical protein	D6PSY5	Lactobacillus_phage	5.2e-19	98.0
WP_157128355.1\|951587_951803_+	hypothetical protein	D6PSY6	Lactobacillus_phage	8.8e-21	94.1
WP_085763039.1\|951771_957495_+\|tail	phage tail tape measure protein	D6PSY9	Lactobacillus_phage	1.1e-138	85.2
WP_085763040.1\|957494_958142_+	LysM peptidoglycan-binding domain-containing protein	D6PSZ4	Lactobacillus_phage	3.4e-108	92.1
WP_191981938.1\|958153_958546_+	hypothetical protein	D6PSZ5	Lactobacillus_phage	7.1e-69	100.0
WP_085763042.1\|958535_959777_+	hypothetical protein	D6PSZ6	Lactobacillus_phage	1.4e-206	90.8
WP_085763043.1\|959776_960121_+	hypothetical protein	D6PSZ7	Lactobacillus_phage	2.5e-57	97.4
WP_085763044.1\|960120_960519_+	hypothetical protein	D6PSZ8	Lactobacillus_phage	5.8e-50	80.2
WP_085763075.1\|960505_961684_+\|plate	baseplate J/gp47 family protein	D6PSZ9	Lactobacillus_phage	2.7e-180	81.1
WP_085763047.1\|961673_962333_+	hypothetical protein	D6PT00	Lactobacillus_phage	2.8e-73	82.4
WP_085763048.1\|962335_964231_+	hypothetical protein	A0A2K9VCK7	Lactobacillus_phage	3.6e-41	58.6
WP_085763049.1\|964242_964671_+	hypothetical protein	NA	NA	NA	NA
WP_157128264.1\|964682_964850_+	XkdX family protein	NA	NA	NA	NA
WP_085763730.1\|964953_965307_+	hypothetical protein	D6PSR9	Lactobacillus_phage	6.5e-37	67.3
WP_085763050.1\|965296_965680_+	hypothetical protein	NA	NA	NA	NA
WP_085763076.1\|966208_967261_+	Lyzozyme M1 (1,4-beta-N-acetylmuramidase)	D6PSS2	Lactobacillus_phage	2.5e-177	97.2
WP_157128265.1\|967339_968137_+	hypothetical protein	NA	NA	NA	NA
WP_085763053.1\|968144_969278_+	ImmA/IrrE family metallo-endopeptidase	A0A0U4JD08	Gordonia_phage	3.5e-23	26.4
WP_085763054.1\|969684_969891_-	DUF3923 family protein	NA	NA	NA	NA
WP_042521251.1\|970063_970441_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_085762957.1\|970858_972034_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_085763055.1\|972429_973611_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_043023458.1\|974388_974856_-	universal stress protein	NA	NA	NA	NA
WP_085763077.1\|975109_975679_-\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_024526645.1\|976066_976390_-	heavy metal-binding domain-containing protein	M4STD1	Rhodobacter_phage	9.2e-06	35.6
WP_043023199.1\|976600_977170_+	hypothetical protein	NA	NA	NA	NA
WP_043023198.1\|977216_977558_-	hypothetical protein	NA	NA	NA	NA
WP_085763078.1\|977662_978370_-	hypothetical protein	NA	NA	NA	NA
WP_015473935.1\|978613_979801_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	9.5e-149	69.4
WP_021742220.1\|980006_981482_+	MFS transporter	NA	NA	NA	NA
WP_011668242.1\|981555_981882_+	DUF960 domain-containing protein	NA	NA	NA	NA
WP_011668241.1\|981929_982577_-	deoxynucleoside kinase	C1KFI3	Lactobacillus_virus	9.1e-45	45.9
WP_043023195.1\|982730_983501_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_085763079.1\|983554_984226_-	beta-phosphoglucomutase	NA	NA	NA	NA
WP_043023193.1\|984238_986953_-	glycoside hydrolase family 65 protein	NA	NA	NA	NA
WP_021742214.1\|987172_988135_-	NAD(P)-binding domain-containing protein	A0A1B1IVB5	uncultured_Mediterranean_phage	5.3e-25	28.7
WP_085763080.1\|988284_988533_+	hypothetical protein	NA	NA	NA	NA
WP_043023191.1\|988841_989522_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_011668234.1\|989573_990050_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_043023189.1\|990605_991124_+	VanZ family protein	NA	NA	NA	NA
WP_085763081.1\|991114_991438_+	heavy metal-binding domain-containing protein	NA	NA	NA	NA
WP_085763082.1\|991793_994304_+	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	4.5e-140	32.6
991467:991487	attR	NA	NA	NA	NA
WP_085762961.1\|994846_995836_+\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	2.2e-58	40.2

DBSCAN-SWA_2

1275918 : 1285172

Staphylococcus_phage(42.86%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011667553.1\|1275918_1276194_+	HU family DNA-binding protein	A0A0H3UZA0	Geobacillus_virus	3.1e-26	68.5
WP_085763171.1\|1276299_1277559_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_179205386.1\|1277677_1278574_-	YitT family protein	M1Q1P6	Streptococcus_phage	9.6e-53	39.5
WP_085763173.1\|1278749_1279943_+\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	2.7e-34	39.3
WP_043022299.1\|1279971_1281864_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	4.7e-49	29.3
WP_021741846.1\|1281875_1282826_+	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	2.0e-117	62.1
WP_085763174.1\|1282842_1283334_+	dihydrofolate reductase	A0A0N9S8H6	Staphylococcus_phage	7.4e-23	37.2
WP_011667560.1\|1283511_1284153_-	hemolysin III family protein	NA	NA	NA	NA
WP_085763175.1\|1284320_1285172_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	5.8e-15	33.6

DBSCAN-SWA_3

1742936 : 1749164

Staphylococcus_phage(16.67%)

integrase

attL 1733593:1733611|attR 1757345:1757363

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1733593:1733611	attL	NA	NA	NA	NA
WP_085763353.1\|1742936_1744337_-	virulence protein	Q4ZD27	Staphylococcus_phage	5.3e-74	37.1
WP_085763354.1\|1744349_1745120_-	bifunctional DNA primase/polymerase	A0A060ADS5	Enterococcus_phage	2.1e-16	31.7
WP_085763355.1\|1745132_1745357_-	hypothetical protein	NA	NA	NA	NA
WP_085763356.1\|1745356_1745587_-	hypothetical protein	NA	NA	NA	NA
WP_085763357.1\|1745898_1746183_-	hypothetical protein	NA	NA	NA	NA
WP_085763358.1\|1746199_1746880_-	Rha family transcriptional regulator	R9QNB1	Lactococcus_phage	4.5e-26	36.0
WP_085763359.1\|1746881_1747097_-	helix-turn-helix transcriptional regulator	A0A1X9I5U5	Streptococcus_phage	3.6e-06	43.5
WP_085763360.1\|1747225_1747864_+	helix-turn-helix transcriptional regulator	A0A0P0IV68	Lactobacillus_phage	1.3e-11	48.8
WP_085763361.1\|1748009_1749164_+\|integrase	site-specific integrase	S6C485	Thermus_phage	3.3e-53	36.0
1757345:1757363	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019752

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP019751

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP019750

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection