CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021110	Bordetella genomosp. 9 strain AU14267 chromosome, complete genome	10 crisprs	DinG,DEDDh,cas3,csa3	2	3	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021110_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_1

233199-233314

Orphan

Consensus_repeat	Method
AGGGGGAAGCGCGCAGCGCTTCGGGGGTGGGCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_1

>merge|NZ_CP021110|1|233199-233314|CRISPRCasFinder
AGGGGGAAGCGCGCAGCGCTTCGGGGGTGGGCCTTCCCCCTCGCGGATCCGGCTCCGCCGGTCCGCCAGCGTCGCCCCCTTGAGGGGGAAGCGCGCAGCGCTTCGGGGGTGAGCCT

>NZ_CP021110|1|1|233199-233314|CRISPRCasFinder
AGGGGGAAGCGCGCAGCGCTTCGGGGGTGGGCCT	TCCCCCTCGCGGATCCGGCTCCGCCGGTCCGCCAGCGTCGCCCCCTTG
AGGGGGAAGCGCGCAGCGCTTCGGGGGTGAGCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086055835.1\|222423_224136_+\|hydantoinase-B/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|376810
NZ_CP021110.1\|WP_086055843.1\|233316_234150_-\|sulfate-ABC-transporter-permease-subunit-CysT	unknown	unknown	gnl\|CDD\|182873
NZ_CP021110.1\|WP_086055837.1\|224678_227657_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086055847.1\|237031_237766_-\|BON-domain-containing-protein	unknown	unknown	gnl\|CDD\|182907
NZ_CP021110.1\|WP_086055841.1\|231060_231888_-\|sulfate-ABC-transporter-permease-subunit-CysW	unknown	unknown	gnl\|CDD\|226665
NZ_CP021110.1\|WP_086059156.1\|229974_230886_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NZ_CP021110.1\|WP_086055838.1\|227837_228320_-\|YajQ-family-cyclic-di-GMP-binding-protein	unknown	unknown	gnl\|CDD\|213038
NZ_CP021110.1\|WP_086055836.1\|224198_224528_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086055849.1\|240502_241468_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_CP021110.1\|WP_086055846.1\|236498_236993_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP021110.1\|WP_086059157.1\|237762_238368_-\|phosphoheptose-isomerase	unknown	unknown	gnl\|CDD\|237567
NZ_CP021110.1\|WP_086055850.1\|241464_242100_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NZ_CP021110.1\|WP_086055834.1\|220373_222431_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_CP021110.1\|WP_086055840.1\|228980_229814_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|180446
NZ_CP021110.1\|WP_086055848.1\|239927_240443_-\|YraN-family-protein	unknown	unknown	gnl\|CDD\|173148
NZ_CP021110.1\|WP_086055842.1\|238773_239730_-\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP021110.1\|WP_086055839.1\|228446_228959_+\|DUF2127-domain-containing-protein	unknown	unknown	gnl\|CDD\|378298
NZ_CP021110.1\|WP_086055844.1\|234378_235389_-\|sulfate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|226630
NZ_CP021110.1\|WP_086055842.1\|232077_233034_-\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP021110.1\|WP_086055845.1\|235545_236385_-\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086055835.1\|222423_224136_+\|hydantoinase-B/oxoprolinase-family-protein	gnl\|CDD\|376810	pfam02538, Hydantoinase_B, Hydantoinase B/oxoprolinase. This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyzes the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to pfam01968.	0
NZ_CP021110.1\|WP_086055844.1\|234378_235389_-\|sulfate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|226630	COG4150, CysP, ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism].	2.57911e-164
NZ_CP021110.1\|WP_086055847.1\|237031_237766_-\|BON-domain-containing-protein	gnl\|CDD\|182907	PRK11023, PRK11023, divisome-associated lipoprotein YraP.	1.45549e-45
NZ_CP021110.1\|WP_086055841.1\|231060_231888_-\|sulfate-ABC-transporter-permease-subunit-CysW	gnl\|CDD\|226665	COG4208, CysW, ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism].	1.0531e-126
NZ_CP021110.1\|WP_086059156.1\|229974_230886_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	3.08617e-51
NZ_CP021110.1\|WP_086055838.1\|227837_228320_-\|YajQ-family-cyclic-di-GMP-binding-protein	gnl\|CDD\|213038	cd11740, YajQ_like, Proteins similar to Escherichia coli YajQ. In Pseudomonas syringae, YajQ functions as a host protein involved in the temporal control of bacteriophage Phi6 gene transcription. It has been shown to bind to the phage's major structural core protein P1, most likely activating transcription by acting indirectly on the RNA polymerase. YajQ may remain bound to the phage particles throughout the infection period. Earlier, YajQ was characterized as a putative nucleic acid-binding protein based on the similarity of its (ferredoxin-like) three-dimensional topology with that of RNP-like RNA-binding domains.	5.7115e-89
NZ_CP021110.1\|WP_086055843.1\|233316_234150_-\|sulfate-ABC-transporter-permease-subunit-CysT	gnl\|CDD\|182873	PRK10971, PRK10971, sulfate/thiosulfate ABC transporter permease CysT.	1.14101e-122
NZ_CP021110.1\|WP_086055849.1\|240502_241468_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	2.74791e-108
NZ_CP021110.1\|WP_086055846.1\|236498_236993_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.20503e-38
NZ_CP021110.1\|WP_086059157.1\|237762_238368_-\|phosphoheptose-isomerase	gnl\|CDD\|237567	PRK13936, PRK13936, phosphoheptose isomerase; Provisional.	9.98199e-117
NZ_CP021110.1\|WP_086055850.1\|241464_242100_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	4.83441e-51
NZ_CP021110.1\|WP_086055834.1\|220373_222431_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_CP021110.1\|WP_086055840.1\|228980_229814_-\|oxidoreductase	gnl\|CDD\|180446	PRK06180, PRK06180, short chain dehydrogenase; Provisional.	0
NZ_CP021110.1\|WP_086055848.1\|239927_240443_-\|YraN-family-protein	gnl\|CDD\|173148	PRK14685, PRK14685, hypothetical protein; Provisional.	2.06128e-32
NZ_CP021110.1\|WP_086055842.1\|238773_239730_-\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.48556e-21
NZ_CP021110.1\|WP_086055839.1\|228446_228959_+\|DUF2127-domain-containing-protein	gnl\|CDD\|378298	pfam09900, DUF2127, Predicted membrane protein (DUF2127). This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.	4.50823e-33
NZ_CP021110.1\|WP_086055842.1\|232077_233034_-\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.48556e-21
NZ_CP021110.1\|WP_086055845.1\|235545_236385_-\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	3.34295e-87

>NZ_CP021110.1|WP_086055842.1|232077_233034_-|transposase
MSEATYVGIDVSSEVLEIAVSTQPSTWQASNDSGGIEQLAGQLQALRPALVVLEATGGYEFEAACVLQAQGLAVAVVNARMARDFARAMGALGKTDALDARMLATFARVLDQHPDRARFVKPLADAQLQRLQALVLRRRQIVQTMTSERHRLRISHEAARPSIERHLAFLRQELDDSDGHIAEHVQQHQAELARVLSSVPGIGAASVALLLAELPELGRLDRRRIAALVGVAPVNRDSGKMRGQRSIWGGRASVRCALYMASLSAVRYNPVLRAYYQRLLGTGKKKKVALVATMRKLLTILNAMVRHNKQWEPALDCP
>NZ_CP021110.1|WP_086055841.1|231060_231888_-|sulfate-ABC-transporter-permease-subunit-CysW
MRKPRNWRQWALIAIGVTGAFMLLVLPLILIFQQALSAGWGAVADNLGDPEMQHAIWLTLLATALTVPINVAFGILLAWCVTRYDFRGKQVLTTLVDIPYATSPVVAGLCYLVVYGMESAVGGWLSQHDIQLMFAWPGIVMVTVFVTSPFVARILIPLMQAQGADEEYAALTLGANGWQIFRRITLPNIKWALLYGTVITNARAVGEFGAVSVVSGAIRGQTVTLPLLIEQLSEDYKTVAAFTAAALLACMALLTMVIKTLMELGHRITMRGPAH
>NZ_CP021110.1|WP_086059156.1|229974_230886_+|AraC-family-transcriptional-regulator
MVALLLALAPQEGYNLTALPDVRILRSDRPLSRTPVLYDPGIVIVCQGSKRGFFRDQVYRYDEQHYLAVAVPVPFVMETDASRQRPLLAIYMHLNFQLAAELAIQIDRHGHRGPAAEPRSMMSSPMDDALKSSVLRFLQVLSDPLEASVLGPALVRELYFRVLTGAQGGAMRSALAMQGQFGKIGKALRLIHAAYAEPLSLTQLAGEAGMSVPTFHAHFKAITGMPPMQYVKSARLHQARLLMLRQSMTAAAACHAVGYESASQFNREFKRLFGLPPAEEARRMRHSFALPPPQPGSPYISSH
>NZ_CP021110.1|WP_086055840.1|228980_229814_-|oxidoreductase
MSSTKTLFITGVSSGFGRALAQEALAAGHRVVGTVRNAQARQSFDALSPGHAFSRILDVTDFAAIEGVIADVETHIGPIDVLVNNAGYGHEGVMEESPLEEMRRQFDVNVFGAVAMMKAVLPYMRERRRGRILNITSMGGFITMPGIAYYCGSKFALEGISEALGKEVRHLGIAVTAVAPGSFRTDWAGRSMVRTPRSISDYDGLFDPIRRARAEKSGKQLGDPIKAARAMLAVIDSDAPPAHLVLGSDALGLIREKLASYAAEIDTWEALSRSTDG
>NZ_CP021110.1|WP_086055839.1|228446_228959_+|DUF2127-domain-containing-protein
MSATDPTARPVSPREASARQRAQRVIALFEALKGLGALAASIGLLSLLHHDLRHIVFVIIGHFGLDPGGHYPEELLRLAALLQDTSVRTLVALAAAYVTLRLAEAYGLWRDRAWGEWLGALSGAIYVPFELRHLLHAPSALSAAVVLANVLIVAFLAWQLVRRRAPRAAA
>NZ_CP021110.1|WP_086055838.1|227837_228320_-|YajQ-family-cyclic-di-GMP-binding-protein
MPSFDVVSEVDKHELSNAVDQANRELATRFDFKGTDARFELEDYVVTQTAPSAFQLKQMLDILRGRLTARGIDPRSMDPAEPVVNLGGARQKITLKQGIEQPVAKKLIAAIKDAKLKVETQINGNKLRVTGKKRDDLQTVIALLRKTDVDLPLQFENFRD
>NZ_CP021110.1|WP_086055837.1|224678_227657_-|hypothetical-protein
MQVSGHGNTPPGSPPAAARTPGNAGAPLLGASVNSPPRAALARRDELPSRNTRPRLLRFFSGGPRRAAARALRAQEKLQASLERFVDRQSMRRIDDLTPKEGARLLKAVCGDIRQFETRARASLAAGGAASPARDACGGAPLPTLDAVLAQCLGRLDASQLHLLYDDLASQPDISRDLIRRQEKALRPVAADFLDTMEQALVRELATRGGRALLDTLLEAAAGAKADPHTLDEALDQLYGIGLSLTSPCRTPAHVLSLMLDSLTDDELGVLAAQAWPDASIGDAHRPPGLLKGAPPGERCEDDARSSAASGNSRLDEAGREIWRQALRAQLREREDRIAVQTVHGAGRNGGVGGGGRAITLGRMMQDIRDIYAGIDARVHALAGRLPTVTELHMRLRYEVLAIMLHHLPLPQRRTSLLALPVSELSSLRTHLDVAPDMSPLRPTVGAALEAVCDEMLHAVHQRTEDALAAVYEAIAREDRPAAAFRLVALAEAVQALNESHAAMGTRAPATLSYSVGRAVELMRTLVCPSAGQARLRQLSDRELGYLRAAIAPLRPFGLIIDKAALKAEIAARATPPKGLGAAMDALLVDMMREDVTPQRVLARLRDIADMLARLGDRRVQCGDEMNADEVADLTYGLVTEALERLDRRDAGARVRVLCGLAGEPPVDDALQDAWAALQQYAGEQRRDGMARLVRPMVILGFAMRIAAFLRHACSSNGLGVARTGTAPTRTDARLPAAIAGEFGVAWDPAAQAAHPCLQAEHHAEFARRLAGPPDAEALRMLPVMLPLPDGEPSWFYVSAAFARDVVHGPGTSIAVDGVDARGRRVRYRGFDASLHGEARRDAVGGALHALRTLAGDAAPALTALLNGGALDAFRQALEAESGGPPLRRPDGTRALLDPGAMGAAHFLVQRLPEGSYRIETTLVYRDCAGKPAPAAAQPQDRTQALPSPAWVKATYALAATAAGVPDGLAAQVDIRYRFDEGPSPGTPPDGA
>NZ_CP021110.1|WP_086055836.1|224198_224528_-|hypothetical-protein
MKLTDIPFGTTDWSAIAPTEHAGTTGKAIWRTRHFGDIRVRMVEYTAGYLADHWCSKGHILLCLAGSLDTELEDGRRFTLRPGMSYQVADGAEAHRSSTPTGATLFIVD
>NZ_CP021110.1|WP_086055835.1|222423_224136_+|hydantoinase-B/oxoprolinase-family-protein
MAELSRTDDGLADPIGMEVFCNRLLSITEDMNNTLVRASFSTNIKERKDCSVALFDAAGRLVAQGTQIPLHLGSLDGAMRAILDRHAIETIEDGDVFICNDPYLANGSHLPDINIVTPVFWEGRLRFFAANIAHHSDVGGPVPGSIAGGLNSIFAEGIRIPVARLARAGKVDEDLLNLICANTRDPEERLLDLRVQMATNRRGAAAMQGLIRQMGLDGVLQSVEDVIRYTRRRLLNRISELKQGSYTFHSDLDDDGLGGDPVRIQVTLTVHPDRLHFDFAGSGPQARGAMNLPVNALRASVYYAVKALLDPDIAPNAGLFEPIEIDAPLGTITNPEHPAAVGARSITAQKVAGAIFGAFRGLLPPEKIMASGNDCCPAIVFSGKWATRPGQFVYLETLGGGAGARYDSDGMDAIHVHMTNTSNLPVEALENEYPLLMDEYAMIPDSGGPGRMRGGLSIAKQIRALGPGIVFSARSDSHTVGVATGVDGGMDGRRARLIRNYGTPNQQELFSKTANIVLEPGESVRIETPGGGGYGAPAQRAPERLQRDLLDGKVSEAAAREHYGFVPERG
>NZ_CP021110.1|WP_086055834.1|220373_222431_+|hydantoinase/oxoprolinase-family-protein
MYRIGIDVGGTFTDFTMIDETAGVVHFHKVPSTPDDPSRAIASGIEGLLDMHGVDPSQVSHVGHGTTVATNLIIERKGAHVGLITTRGFRDVLEIGRQTRPHLYDYSVGKPPVAVPRQFRIEVAERVQATGEVREPLDEQAVREAARHFARHGISAVTICFLHSYRNPVHEQRARDIVAEEMPGAYISLSSEVLPEFREYERLSTTVLNAAVGPRMASYLERFLLRVRELGIAHEPHTVHSNGGLMSIASVRQFPVRTCLSGPAAGVVGAAAVGRVIGSPNLVTFDVGGTSTDVSLICDGKPLFTSHRHVAGYPVKTPMVDIHVIGAGGGSIAWMDDAGALKVGPHSAGAVPGPVGYGRGGVEPTITDAEIVLQRLNPVSLLSGRMPVYAEQARQVIQEKVARPLNLGIEAAAEGILRIATANMSRAIRAVSTERGYDLSQFALFAFGGAGPLHAVEVAEECGIPRVIVPQEPGTMCARGILLSDISFDFVRSEIALATPQNWTRVAAIFESLRRQADEWLASEGVATGLRAAHCAIDARYEGQNFEVQVPLDDTAESGFQAFLERFAQAHMREYGYDVDDRAIQIINCRVQATGQVIKAPLSPRKVEGTMAQARIGQRDAYFGAANGWLETPVYDRGRLPTGVAFQGPALVEEMSSTTVIGVGHSAVVDDYGNLIITLQGNANG
>NZ_CP021110.1|WP_086055843.1|233316_234150_-|sulfate-ABC-transporter-permease-subunit-CysT
MPTFFKQNPTLPGFGLSFGVSSLFISLVILFPIAALLAYTSEMSAAQYWQAITDPRVVASYRVTLLGAAISTIVVVLFGLLLAWILVRYRFPGRLLLDSLVDLPFALPTAVAGLTLSVLLGPNGWIGQWFDQAGIKISYAFPGLVSAMIFTSLPFVVRSVQPVLEEIGPEYEEAAHTLGATDWQTTWRVLLPSLTPALFTGGSQAFIRSLGEFGAVVMIAGNIPFKTEITSLMIFVRVSEFDYAAASAIATVVLGASLLLLFGLHVLQGRLLPWGKA
>NZ_CP021110.1|WP_086055844.1|234378_235389_-|sulfate-ABC-transporter-substrate-binding-protein
MIKRLLATSLAATLMLGAGAASAQQNLLNSSYDVARELFTAINPQFVEYWKQKTGETVNIEQSFGGTSRQAQAIIQGLKADTVTFNQVPDVDILAKRGLLAKDWQKRFPDNSSPYYSTIAFLVRKGNPKHIQGWDDLVRDDVKVVFPNPKTSGNARYTYLAAWLYAQKKFNGDEAKTRAFVGKLLHNVESFPTGGRGATVAFAQNNQGDAVLTFESEVRNIAASEEFKPLGLEVVVPKTSVLAEFPVAVVDKVVDAKGTRKLAEAYLQYQYSPEIQKLLASYNYRVRDPEVVKANADRFPQVELLDPQQLLGGWDKIQDTHFKGGGVLDQLLAGKS
>NZ_CP021110.1|WP_086055845.1|235545_236385_-|NAD(+)-diphosphatase
MADSTASSPSGIADAIVPPHGRVFAFRGSELLVREDGLSLPGDEVRGRIAEAVQWQSIGDYLGQPCVAAALKRDAAAPAGYVFKRLREMLNVLGEEGAGVASRAFQIAEWARTHRFCGACGTATVRVPEEYCMKCPRCGLSAYPRISPAMMVLVRWGDRILLARNASFVTGRYSALAGFVEAGESLEATVHREVYEEVGLRVRDLKYFRSQSWPFPHSLMLAFTAEYDGGDIRVDGQEIVDARWFGPDDDLPDIPPMDSIAGHLIRANLPQGKRPRGDR
>NZ_CP021110.1|WP_086055846.1|236498_236993_-|TlpA-family-protein-disulfide-reductase
MKKLLIAMVVAIAAGIAGWFVWRPVQAAPDVTFASIDGRKISMQDLRGKVVLVKFWATDCVTCIKQMPDTIADYNRYAPQGFQTVAVAMQYDPPNYVLNYAQTRKLPFTVALDTQGKAAQAFGDVRLTPTAFLIDKQGRIIKRYLGDYDPKAFHAEIEKALAAG
>NZ_CP021110.1|WP_086055847.1|237031_237766_-|BON-domain-containing-protein
MTLKTRMLAIPVAIALGASALSGCAPLVVGGAAAGAAVVVTDRRTSGTQVEDQNISFKVERNMSQKFGDTARVNASTYEGVVLLTGEVPNEAAKTQATSLAQGVENVKRVVNQLTVGPVASFTARSNDTWLGSKVRTELLNTKFVPSGTISITTDKGVVYLQGKVTQAEGDYAANAAAGVSGVTKVVKLFDVISREEALRLSGTNSSGTSAPASGATKPAPIETGGGSDSGSAPTGGAEAIPIK
>NZ_CP021110.1|WP_086059157.1|237762_238368_-|phosphoheptose-isomerase
MRAMTDMTTRMVSHFNDATATLQAARDVLAEPLAVAVELLFGALANNAKILACGNGGSAADAQHFVAELVGRFERERLPLAAVALNTDTAILTAVGNDYGYDEVFERQVNALGQPGDALLAISTSGNSPNVVRAVQAAQARDMHVIALTGKGGGVIGELMTPHDVHLCVPSDRTMRVQEAHIVLLHALCDGIDALLLGDPE
>NZ_CP021110.1|WP_086055842.1|238773_239730_-|transposase
MSEATYVGIDVSSEVLEIAVSTQPSTWQASNDSGGIEQLAGQLQALRPALVVLEATGGYEFEAACVLQAQGLAVAVVNARMARDFARAMGALGKTDALDARMLATFARVLDQHPDRARFVKPLADAQLQRLQALVLRRRQIVQTMTSERHRLRISHEAARPSIERHLAFLRQELDDSDGHIAEHVQQHQAELARVLSSVPGIGAASVALLLAELPELGRLDRRRIAALVGVAPVNRDSGKMRGQRSIWGGRASVRCALYMASLSAVRYNPVLRAYYQRLLGTGKKKKVALVATMRKLLTILNAMVRHNKQWEPALDCP
>NZ_CP021110.1|WP_086055848.1|239927_240443_-|YraN-family-protein
MPDDPSALPFEVARHAQAKRLRRRRRNRRGDDASPLPDAVAEADQTLPAQSASQRRGGGYEDRALALLVRAGLQPLGRNLRCRAGEIDLALRDGWTLVLVEVRARRDDRFGGAAASVGHAKQARLIRAAHVLAPRLIARFWAGRPAAVRFDVVAFEGETPFWLRHAFSLEG
>NZ_CP021110.1|WP_086055849.1|240502_241468_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MNENVPVPAAIDSGADARAPGGDAWRRVAERVAAQQWPAAALYVVATPIGNLGDLGLRAWQALARADVIAAEDTRESRTLLDAWGVATPLMAAHRHNEAAAAQAICERLARGERVALISDAGAPAVSDPGARIVREVRQAGYAVVPVPGASAVIAALMASGVTSDENPAYVFAGFPPPKSAARQRWLAQWCALPAPVVMYESPHRLAATLADLAQVCGPARDVTIARELTKRFEEVATVPAGEAADWLQAQPHRGQGEFVVIAHPAPPAAADAQAADPATDALLDALLESVSVRDAARIAARVSGLPRDVLYARALARKPA
>NZ_CP021110.1|WP_086055850.1|241464_242100_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MIARGSRHPNGTGTAGPCVRVVDTPLGAMRLQAEGGALTGAWFLDQRDCPAMPEPAAEASPSPDAGGRDSRSAEDAVLDQAVRELAEYFAGRLRAFSLPMAPQGTPFQRRVWDALRDLDFGVLESYGALAQRCATPAAVRAVAQAVGRNPISIFIPCHRVVGADSALTGFGGGLHRKQALLALEGHAYASPARQARRAQQDPRQGSLWDSP

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Crispr_ID: NZ_CP021110_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_2

958892-959013

Orphan

Consensus_repeat	Method
GGCGGAGCCGGATCCGCGGCGCCTTGATTGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_2

>merge|NZ_CP021110|2|958892-959013|CRISPRCasFinder
GGCGGAGCCGGATCCGCGGCGCCTTGATTGGCCCTGGTTCTTTTGTGGTGGAAGGGGGTGTGGAGCGCTATTGCGCTTGCCCTCAAGGGGGCGGAGCCGGATCCGCGGCGCCTTGATTGGCC

>NZ_CP021110|2|2|958892-959013|CRISPRCasFinder
GGCGGAGCCGGATCCGCGGCGCCTTGATTGGCC	CTGGTTCTTTTGTGGTGGAAGGGGGTGTGGAGCGCTATTGCGCTTGCCCTCAAGGG
GGCGGAGCCGGATCCGCGGCGCCTTGATTGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086056397.1\|967341_968199_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|381147
NZ_CP021110.1\|WP_086059253.1\|945329_945929_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|226226
NZ_CP021110.1\|WP_086056392.1\|961138_961939_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP021110.1\|WP_086056398.1\|968689_968923_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086056395.1\|965633_966290_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP021110.1\|WP_086056387.1\|953257_954136_-\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|238817
NZ_CP021110.1\|WP_086056384.1\|949139_950033_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112
NZ_CP021110.1\|WP_086056382.1\|947455_947866_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_CP021110.1\|WP_086056399.1\|968931_969198_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086056391.1\|960433_961090_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP021110.1\|WP_086056389.1\|956545_958768_+\|glycoside-hydrolase-family-31-protein	unknown	unknown	gnl\|CDD\|376446
NZ_CP021110.1\|WP_086056383.1\|947940_948987_-\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP021110.1\|WP_086056396.1\|966295_967234_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP021110.1\|WP_086056386.1\|951432_953133_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235923
NZ_CP021110.1\|WP_157664392.1\|962606_965015_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274846
NZ_CP021110.1\|WP_086056394.1\|965169_965637_+\|type-III-secretion-system-chaperone	unknown	unknown	gnl\|CDD\|341100
NZ_CP021110.1\|WP_086056390.1\|959388_960480_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236863
NZ_CP021110.1\|WP_086056385.1\|950060_951281_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349916
NZ_CP021110.1\|WP_086056388.1\|954345_956217_+\|FAD-dependent-5-carboxymethylaminomethyl-2-thiouridine(34)-oxidoreductase-MnmC	unknown	unknown	gnl\|CDD\|234978
NZ_CP021110.1\|WP_086056381.1\|945969_947442_-\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086056397.1\|967341_968199_-\|response-regulator-transcription-factor	gnl\|CDD\|381147	cd19920, REC_PA4781-like, phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains. Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	7.00793e-48
NZ_CP021110.1\|WP_086059253.1\|945329_945929_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|226226	COG3703, ChaC, Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism].	5.12827e-52
NZ_CP021110.1\|WP_086056392.1\|961138_961939_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	3.66457e-131
NZ_CP021110.1\|WP_086056395.1\|965633_966290_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.32499e-50
NZ_CP021110.1\|WP_086056387.1\|953257_954136_-\|inositol-monophosphatase	gnl\|CDD\|238817	cd01639, IMPase, IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling. IMPase is one of the proposed targets of Li+ therapy in manic-depressive illness. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria.	1.04886e-102
NZ_CP021110.1\|WP_086056384.1\|949139_950033_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.74761e-64
NZ_CP021110.1\|WP_086056382.1\|947455_947866_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	1.99981e-47
NZ_CP021110.1\|WP_086056391.1\|960433_961090_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	8.04914e-99
NZ_CP021110.1\|WP_086056389.1\|956545_958768_+\|glycoside-hydrolase-family-31-protein	gnl\|CDD\|376446	pfam01055, Glyco_hydro_31, Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.	4.44098e-91
NZ_CP021110.1\|WP_086056383.1\|947940_948987_-\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	3.69523e-95
NZ_CP021110.1\|WP_086056396.1\|966295_967234_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.79049e-20
NZ_CP021110.1\|WP_086056386.1\|951432_953133_+\|AMP-binding-protein	gnl\|CDD\|235923	PRK07059, PRK07059, Long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP021110.1\|WP_157664392.1\|962606_965015_+\|AAA-family-ATPase	gnl\|CDD\|274846	TIGR03903, TOMM_kin_cyc, TOMM system kinase/cyclase fusion protein. This model represents proteins of 1350 in length, in multiple species of Burkholderia, in Acidovorax avenae subsp. citrulli AAC00-1 and Delftia acidovorans SPH-1, and in multiple copies in Sorangium cellulosum, in genomic neighborhoods that include a cyclodehydratase/docking scaffold fusion protein (TIGR03882) and a member of the thiazole/oxazole modified metabolite (TOMM) precursor family TIGR03795. It has a kinase domain in the N-terminal 300 amino acids, followed by a cyclase homology domain, followed by regions without named domain definitions. It is a probable bacteriocin-like metabolite biosynthesis protein. [Cellular processes, Toxin production and resistance].	7.72332e-24
NZ_CP021110.1\|WP_086056394.1\|965169_965637_+\|type-III-secretion-system-chaperone	gnl\|CDD\|341100	cd16364, T3SC_I_like, class I type III secretion system (T3SS) chaperones and similar proteins. This family contains class I type III secretion system (T3SS) chaperones mainly found in Gram-negative bacteria such as Pseudomonas, Yersinia, Salmonella, Escherichia and Erwinia, among others. A wide variety of these bacterial pathogens and symbionts require a T3SS to inject eukaryotic host cells with effector proteins important for suppressing host defenses and establishing infection. Many of these effector proteins interact with specific type III secretion chaperones prior to secretion. These T3SS chaperones have been classified as class I type III secretion chaperones (T3SC), which are small structurally conserved dimers that interact specifically with T3SS effector proteins. Class I T3SC consists of two subclasses: IA and IB. Class IA T3SC binds a single effector, whereas class IB T3SC binds to several effectors. Class IA and Class IB T3SCs typically exhibit little sequence similarities, but share a common overall heart-shaped structure fold (alpha-beta-beta-beta-alpha-beta-beta-alpha) and features, such as a small size, an acidic pI and an amphipathic C-terminal alpha-helix. Chaperone protein CesT serves a chaperone function for the enteropathogenic Escherichia coli (EPEC) translocated intimin receptor (Tir) protein, which confers upon EPEC the ability to alter host cell morphology following intimate bacterial attachment. In Pseudomonas aeruginosa, chaperone ExsC binds small secreted protein ExsE as well as the non-secreted anti-activator protein ExsD; it relieves repression of the transcriptional activator ExsA (which activates expression of T3SS genes) by ExsD. P. aeruginosa SpcU binds the cytotoxin ExoU, which is a broad-specificity phospholipase A2 (PLA2) and lysophospholipase, and maintains the N-terminus of ExoU in an unfolded state which is required for secretion. Salmonella enterica chaperone SicP forms a complex with effector protein SptP at an early stage of its secretion process in order to avoid premature degradation, while chaperone SigE binds to effector SigD, which, upon translocation into the host cell, preferentially dephosphorylates specific inositol phospholipids that are thought to be crucial for subsequent activation of the host cell Ser-Thr kinase Akt. This family also includes Yersinia chaperone/escortee pairs SycE/YopE, SycH/YopH, SycT/YopT and SycN+YscB/YopN, all of which bind to specific Yersinia outer proteins (Yops). Also included are several DspF and related sequences from several plant pathogenic bacteria. The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. In addition, a group of proteins including Escherichia coli YbjN, Erwinia amylovora AmyR, and their homologs, are included in this family. They share a class I T3SC-like fold with T3SS chaperone proteins but appear to function independently of the T3SS.	4.15727e-23
NZ_CP021110.1\|WP_086056390.1\|959388_960480_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	2.58273e-166
NZ_CP021110.1\|WP_086056385.1\|950060_951281_-\|amidohydrolase	gnl\|CDD\|349916	cd05666, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NZ_CP021110.1\|WP_086056388.1\|954345_956217_+\|FAD-dependent-5-carboxymethylaminomethyl-2-thiouridine(34)-oxidoreductase-MnmC	gnl\|CDD\|234978	PRK01747, mnmC, bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC.	1.99077e-180
NZ_CP021110.1\|WP_086056381.1\|945969_947442_-\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	2.02725e-141

>NZ_CP021110.1|WP_086056389.1|956545_958768_+|glycoside-hydrolase-family-31-protein
MPPKFDFAHTNQLESIELSTARPSRIDFDTGDGLRFVVEAHAPGVYRIRCGFPQTLSEDKPSLREKAVAEMLLARQEAVGEATVTPREGGGWRIVQGETALEVLTDPVRIALYKGDKQVLASEVSEHAPGFGYNALEESEEAQWTAGFALDAADRIYGLGETPGDLNRRDEEVVSDDPEHRALPLAWSPSGWGVYVNTIRRVQHTLGAAPADSAYIVTVDDPVLDIFLFAGEPAEILNQYTALTGRAGQPVLWAMGVWLRQAEGEMATQTTALIERCRVMEIPLDAVQLAPPAAWAFQPDKLQFEWDAARFPDARQLFALFHKHHVHVCAPGFPGVPRHTPLFEELEDRGWLLTRDDGNAQVFDGTPVSGGRPYGLLDLTNRDVYGLWTERQRQLIEDGLDAPSCDIQLAIPDGITARGGESGPALRTIYPLLARRALFDAIAGHKVPPEGVVPSTDLFPAAQRLPWQNGPRVSNDWEGLQHTLRTALSIGASGLPVQVHAIGNAAAPMDGMTPELYLRWLTFGVFSANFCFEGVEKLLPWSFGDEVLTHARTWLQWRYRLIPYVLGAVEDAVRTGLPVQRSMAMAFPHDPDAHAWDLQYLLGPALLVAPIVQPGNEVRVYLPKGEAWWDLNTGHRYEGGTTWTVSCGLGQYPVFGREGHMLCLGPAAHHTGEFNSARILDEVWMFGMPMHNPVVMRNKIRVMQMQGSSYIKGLEGLRILPSEGLEVKRRGAEVRISRAR
>NZ_CP021110.1|WP_086056388.1|954345_956217_+|FAD-dependent-5-carboxymethylaminomethyl-2-thiouridine(34)-oxidoreductase-MnmC
MSESSSVAYRPLKPAAPVIDARGVPFSPEYGDIYHAADGALAQAQHVFLRGNDLPQRWRGRASFTVCETGFGLGSNFLALWLAWRADAQRPRRLHVVSFEAHPLLPQDLAGALARLPADSGCRVLADQLLRQWPPLLPGVHRLEFERGGVTLTLAFGDAGTLAPQLDFVADAFFLDGFAPARNPEMWTPALLQALGAHAAHDATAATWCSAGRVRRALQEAGFAVDRRPGFAGKTHMTVARRIAAGRAPAGDPPPHVAIVGAGIAGAAVAQALGLRGIPVTLLDPAHDAAHRGHLAAAATPLVALDDNPRARLSRAGTLRALARWGDLDGDARPLQCGTLQLSRDAGRAADAGKVLAALGFPASWVRQVDAAEASDIAGLAVSRGGLFFQAGLLVRPDALIHALSAVPGVRRVPGAVHRMERNGDTWRLEDEAGRVLADAPVVVAANAVGARRLLHASGLLEPLPRLAQMHALAGEVTLLPAHALAGGPRCIIGGEGYLLPAVHGHCVAGSTYVHGAAEATVSAGGQGVNLAKAAALLDADAAAAVGSMAAGALSGWAGWRAVLPGRLPAVGPVSHAEGLYLATGFGSRGLSWAALAGDIIAAHLCGEPAPLENDLLRAIAPR
>NZ_CP021110.1|WP_086056387.1|953257_954136_-|inositol-monophosphatase
MQTPAQLSQNAPLDLCAALDAAVTAAHAGAAILQSYAHHRSDLVIDRKARNDLVSQADREAEAAVIEELRTRTPQFGIVAEETGGQVAGPATWYIDPLDGTTNFLHGIPQYAVSIALIAHAGTRLAAGPALTEDTPVVAAIYDPNREEMFTAVHGSGAWLNGRRIACSRTQTLDDAVVATGFPFRDFSFAQQYMPTLHEAINVTRGVRRLGAAALDLAWTAAGRYDGYWEMGLAPWDVAAGTLIVREAGGVAEDMYGVDPWPIGGYVISGNQAIAAALKAMIAPHLSRGTAA
>NZ_CP021110.1|WP_086056386.1|951432_953133_+|AMP-binding-protein
MQRPWLAEYPAGVPAEVSVDGYVSLVDLLDRACERYATRIACTAMGTNLSYEAIDIHARRFAGWLQSLDMPRGSRVAVMLPNVPAYLACMLGTLRAGHVLVNVNPLYRPAELERQLRDAGAQVIVILENFAHTLQSVAELGGVRHVVVTAIGDLLGGIKETVVNLAARHVKKVVPPWRIEGALRLPRALALGQRHGFEQPALSMEDLAILQYTGGTTGTPKGAMLTHRNLAVNILQTEAVAWPALHDVPGQLTIISALPLYHVFAMTVCGLYGMHAGMRNLLILNPRDQPALIKAWRAVPVHIFPGVNTLFNALARNPAFASLDFSALRLTFGGGMAVQRAVADRWRAITGRPIIEGYGLSETSPVAAVNPTDTHVFSGTIGLPVPSTDVAILDDEGHAVPEGERGEVCIKGPQVMRGYWQRPDETRQVMTDDGYFRTGDIGTMDRRGYIRIVDRKKDMIVVSGFKVYPNEVEDVIATHPGVQEVAAVGVADERSGESVRVFVVPKDPSLSEADVLAWCRDKLTGYKRPRSVVFRTELPKTNVGKILRRELREAAQDTAESATAAS
>NZ_CP021110.1|WP_086056385.1|950060_951281_-|amidohydrolase
MKLLEPIIAWQADLAAIRRDIHAHPELCFEEFRTADVVAAKLQEWGVEVHRGLAGTGVVGIIRGRQADGGRAVGLRADMDALPMQELNTFPHASRNPGRMHACGHDGHTAMLLGAARYLAAHRDFAGTVYAIFQPAEEHGGGAKRMIDDGLFEQFPMEAVFGMHNWPGMAAGTFGLTYGPIMASSNDFRIVITGKGAHAGMPHLGIDPVMTAVQLAQSLQTIITRNRNPLDAAVLSITQIHAGSADNVVPTTAEMRGTVRTFTVESLDLIEQRMRDISVHTCAAMGCEADFDFQRHYPPTINHPREAAFCAEVLRDLVGAAAVNDQVQPSMGAEDFAFMLQEKPGCYVWIGNGAGDHREAGHGMGPCMLHNGSYDFNDELLPLGASFWVQLALRWLSSEQPPLQAR
>NZ_CP021110.1|WP_086056384.1|949139_950033_+|LysR-family-transcriptional-regulator
MTPEQLLTFAHVAEAGNISRAAELLHLSQPAVSGQLRALQEWFGEPLYRRSGHGIVLTAAGERLVEHARQLRQAYGQARELRDAWRGIASGLLRLGASTTPASYCLPALVAAFRAKYPAVSLQLADGNTAEIVQRLPLLDMAFIEGDIPAGLPADTAVHAWRQDEVVAIVPADHPLADRRAITLADLAHYPLVMREPGSGVRRLVERAFRSEGLAPGAALELAGVEGVKQAVRAGLGIGFVSAMSMRHEDGALTALRVGRKGLTRTLSILLPNASAPARAAALFLQMCREDAADAPH
>NZ_CP021110.1|WP_086056383.1|947940_948987_-|YeiH-family-putative-sulfate-export-transporter
MSTSTTSLSLATPWRDKLNGVLFVGLLAAAVMQLATLPFLRQLGFSPLVIGIVCGMLYGNFLRGSMPQDWSAGVNFAARRLLRIAVAFYGLNISVQQIAAVGLPGLAVSTAVVAGTLLLGTVVGQRLLGLDRDTAMLTAAGSAICGAAAVLAFEPTLRAQPHKSAVAVATVVLFGTLSMFLYPVLYHAGWLPFDTRHLGIYIGGTVHEVAQVVGAASNVDPATTEIATIVKMTRVALLVPVLLVLGLWLRRSAQAAHAGAEAARLPIPWFAIGFLALAMVNSLDILPHDAVAHLRQLDVFALTMAMTALGIETRFSQIRKAGPRVLALGFILFLWLIFGGYGLVALLA
>NZ_CP021110.1|WP_086056382.1|947455_947866_-|acyl-CoA-thioesterase
MTTSRTSPVVSLPANREPVLRVMPMPADANVHGDVFGGWIMAQVDIAGSVPAARRAAGRVATIAVNSFIFKQPVFVGDLLSFYADIVKTGNTSITVEVEVYAQRQRLDAEIVKVTEATLVYVATDDARRSRPLPVL
>NZ_CP021110.1|WP_086056381.1|945969_947442_-|magnesium-transporter
MTEPAIAQKPQATPRRLDPEDAQHALAEVQELLRRQELVASLVHRQEEGDTRADLVEQLVHRQHETELKALVDGLHPADIAFILESLPKDERQTVWKLVSAEHDADVLLEVEDWVRESLIEAMDRQDLVAATENLDADELADLAPDLPADVVAEVQKGLTDEERAQLLEAMGYPEDSVGAIMDFEMVRVREDVSLEVVLRYLRRLHELPDHTDQIFVVDRQDKLQGILPLSTLLVSEPETVVRDVMTTDYLTLSALDSDADAAGAFERYDLVSAPVVDDQGRLIGRVTIADVVDVIREDSQEQALSRAGLQEEDIFAPVMMALRNRAPWLLFNLCTAATASFVASRFEGTVSHIVILAFLMSIVAGIGGNSGNQTMTMIIRALAVGRITGRNLWQLVKRELLVTLLVGLCGSVVAALFAWAISGSISIALVMMAAMVCNMLVGASVGVLVPMVRDRFGKDPAIGSSVLLTFATDSLGFFIFLGLATIFLL
>NZ_CP021110.1|WP_086059253.1|945329_945929_+|gamma-glutamylcyclotransferase
MPRRAFPQTDSCACLSPASMLAGWDGQRDLWVFAYGSLIWRPGFDWQERRLATVHGYHRSLCLWSRHHRGSDQAPGLVFGLDRGGCCRGVAFRIAAAQVPATFAALWDREMIGGAYRPKWLTCQSEQGPVTALAFLLNRACADYAGDVAEERRLDIIRTAVGRSGACLEYVLETDRALRNHGITDCRLGELVRRLAPAF
>NZ_CP021110.1|WP_086056390.1|959388_960480_+|ATP-binding-cassette-domain-containing-protein
MIHIQNLHKTYATPHGRFEALRGITLHIAQGEVFGIIGPSGAGKSTLVQCINLLERPDEGTISIGNQSLTGLPEVQLRQQRRRIGMVFQGFNLLARRTVYGNVALPLEIAGVPRADIPARVERLLRLVGLEHLRDRFPAQISGGQKQRVGIARALANEPDVLLSDEATSALDPETTHNILALLRDINRQTGVTVVMITHQMEVVREICDRVAVLSQGQIVELGRTAEIFASPRHEVTKAMVSAATASELTDATLQALRARMRDAVSARPDAAVHLLRLSLGGAQGAGDVLSDLSRRFSLDVSLIQARIEDVQGIAVGTAFVLVQGATQALQHALSDLAARDIAVQELAHEPATTDRSSHYVAA
>NZ_CP021110.1|WP_086056391.1|960433_961090_+|ABC-transporter-permease
MNPQQLIDLLTTSLLETLLMVGVSGCIAVIAGIPIGVALVVTSRGAMLQHLGINRVLAIIVNATRSVPFIILMVAIIPFTRWIAHTSIGTTAAIVPLSLAAIPFMARIAENAMREVDPGLITAARAMGASPLQIIAKVLLPEALPGLVAGTIVTLVSLVGYSAMAGAIGGGGLGDMGIRYGYQRFLPDVMLAVVVVLIALVQIVQSIGDWIVRRMSHR
>NZ_CP021110.1|WP_086056392.1|961138_961939_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKLNSIKAIATLALAAGVVLAPAASAQDKPLTVGVTAGPHAEIMEVVKQEAAKQGMAIKIVEFSDYVQPNVALAAGDLDANSYQHQPYLDNANADRGYNLVSIAKTVIFPIGIYSKKVKSLADLKEGARIGIPNDPTNGGRALLLLQAQGLIKLKEGVGLKATPLDVASNPKKLRFIELDAAQLPRSLDDTDASAVNTNFAMQAGLDPKRDAIAQEAPDSPYANVLVVRAKDKDRPEFTKLVAAYHSQPVKDYIQTKYRGAVIAAW
>NZ_CP021110.1|WP_157664392.1|962606_965015_+|AAA-family-ATPase
MQRSMCDGSTEPAIRRRGNRIARLIPASDALHRQCPEMPQASPRILSPGARSVPSTLCIRSIENIRPTSIPMSQILDRPVRICLLGEFQLFVEGVDKTPLIAYSKPKLLLALLALSLEKKQSRAVLAEMLWPNCASGARANLRHALCVLRHVLGPMEKAVLSTSSTLALDQDLVTVDVLALCGIGAYSGLTLEQRLACDRGELLEQLVTPVNAALSAWRMSWQSRLSQEVSQCRQTYIARLCERGAMQEALESARQWVQIHPGDEHAHRDLIRLLRDSGRREAATKAYEHCVAVMGEYYGTGPSAETRSLLDVESPSDRAVNMAASPHADARPIAVLAIAIGHDRDAMAGEDVIDRVQKVRQRLIRLAQAAGRRICLGADGNLAVLFGYPMLNERPAEAAARLACFIQRHVLASNVSLGMGIHADLAYVPPDSGSLPMMLVGQKALRLAYLAETGETLLSDAARTRLSDRFTVREDERYGLKIGVLQGPCQTITVHRMFGRTTEFDILVRRWNSLRRDGRPHVMYLRGEQGIGKSLLAKVFAEYVKRGGGSVATLRCDQENRHTPLHPFHDYLLDRLNACEQGAADPAWACEVRYAQAMEFLGYKLGLDRQTSNALVDHFLSMRSVAGVDVRHPEVAGLIPPLATMLLHADGQGQPLLVMIDDAQWMDEATRDVLLAALQNRRRDPVMILICGRNLQLSVSADETITMPPLPRDAMVQLVSHRAKDSRLSPKLRKRIVEKARGVPLYAEQMVLHMPADIESEPSPLILDLLAVRAICERDDETDSVQPRVEDEYSLPFLEAD
>NZ_CP021110.1|WP_086056394.1|965169_965637_+|type-III-secretion-system-chaperone
MDARSLIALFGEESGVPLSLGESGTIDLIFENNITVTLEHDDAQDILHAYIVVGQEPVESTQCLALYRDMLCSNAFGHETEGATLALDERNGEILLTRRMELADATVSQLRRIVETMVDVGVVWKEKIGTLCHQGLGGEGIPSERPASRPGGLRA
>NZ_CP021110.1|WP_086056395.1|965633_966290_-|response-regulator-transcription-factor
MDLGRSVIRVILADDHPIVLLGVKNALEAVGGISIVGTATSPQSLLACLSACDCDVLVTDFSMPSERSPDGIAMLLDIQRKHPGLRIVVLTKISTPALLTPILDAGALALVDKGATTAEIATAVQRAAHGMTYISRNIEHTLGALGVAPSKVAQRVPLSPREIEVVRLFAQGYSNNQIAEILHLSPKTTSRQKKDAMRKLGAVHDADLYSCARDLGLI
>NZ_CP021110.1|WP_086056396.1|966295_967234_-|AraC-family-transcriptional-regulator
MSSIPTPFLPPCGEATAPQSAAPQGSIGGSFGADAYPRPSHVVVVSDAPEQLQATIDFLRAQLFRVTLASGWRGYHYAQAWHPDIIVIDGGMSNMDPLMLGRLLMQAPDTRGTPLVFLFERHNQAASREAFALGAVDCMVKPVYPEEVLARISTHLRSGARRRIEPMSPRTRTVASEDLLLRNALNAIALDVGSIHTVRQLARSVGTNERKLSALFKSKMGKSAHKVILGKKMETARRLLAQTGMPVRDIGVHVGFPSVCNFSVAFRRENGITPTAYRRQFRAMTQPISNSATATLRTPPTNYGHETEGVRA
>NZ_CP021110.1|WP_086056397.1|967341_968199_-|response-regulator-transcription-factor
MPYEHAGELPTRLLLADDSPADLKLLVQMLSQEGFKLMVALDGKQAYERALADPAPDAILLDVAMPKLDGYSTCKLLKENPATAHIPVIFVTACTKLDDRLKGFDVGGADYVLKPYNPEEVLARIWVQLQRRGRRAAAPKHESTAPGKGSDTMPLSNEQAIVSMTTQYLREHLSDAPSQKRLARLIGVNEKRLTHAFRSLLGKSIPDYLRDQRMERARTLLQDRSLSVAEIADRLGFSSPANFASAFRRQSGCSPVAFRRNASGPSSSVPPGTLVAQNSSIFQNN
>NZ_CP021110.1|WP_086056398.1|968689_968923_-|hypothetical-protein
MNLDNFGLDNLTTQLNTDEDAVDASVQDISGKPSPALPDLYAFQKAITKLSVKSTVVTNYVKSMGDMLKTIARNIVP
>NZ_CP021110.1|WP_086056399.1|968931_969198_-|hypothetical-protein
MEAHQIPISDYAALTLFGLTPGGADARALIQHFKTLEARAKQYMRLQLRPADFQTAATVAQAAVAAQAILTKMGACAESAVPHPLHTK

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Crispr_ID: NZ_CP021110_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_3

1557905-1557992

Orphan

Consensus_repeat	Method
GGCGGACCGGCGGAGCCGGATCCGCGGCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_3

>merge|NZ_CP021110|3|1557905-1557992|CRISPRCasFinder
GGCGGACCGGCGGAGCCGGATCCGCGGCGTCCCCGATCGTGGGGCGTCTGTTTTCTTCGGCGGACCGGCGGAGCCGGATCCGGGGCGT

>NZ_CP021110|3|3|1557905-1557992|CRISPRCasFinder
GGCGGACCGGCGGAGCCGGATCCGCGGCGT	CCCCGATCGTGGGGCGTCTGTTTTCTTC
GGCGGACCGGCGGAGCCGGATCCGGGGCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086056869.1\|1561136_1562057_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|182646
NZ_CP021110.1\|WP_086056874.1\|1564885_1566256_+\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|224241
NZ_CP021110.1\|WP_086056866.1\|1558059_1558779_+\|3-deoxy-D-manno-octulosonic-acid-kinase	unknown	unknown	gnl\|CDD\|234975
NZ_CP021110.1\|WP_086056872.1\|1563220_1563913_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|234840
NZ_CP021110.1\|WP_086056861.1\|1552799_1553219_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176106
NZ_CP021110.1\|WP_086056867.1\|1558906_1560007_+\|polyamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270377
NZ_CP021110.1\|WP_086056862.1\|1553204_1554113_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP021110.1\|WP_086056871.1\|1562850_1563207_+\|arsenate-reductase	unknown	unknown	gnl\|CDD\|239333
NZ_CP021110.1\|WP_086056863.1\|1554358_1554556_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086056859.1\|1548993_1550370_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NZ_CP021110.1\|WP_086056858.1\|1548250_1548967_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181044
NZ_CP021110.1\|WP_086056865.1\|1557308_1557737_+\|group-II-truncated-hemoglobin	unknown	unknown	gnl\|CDD\|381282
NZ_CP021110.1\|WP_086056875.1\|1566338_1567016_+\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_CP021110.1\|WP_086056873.1\|1563964_1564714_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378479
NZ_CP021110.1\|WP_086056870.1\|1562053_1562854_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|182574
NZ_CP021110.1\|WP_086059324.1\|1550979_1551885_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP021110.1\|WP_086056864.1\|1554759_1557312_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP021110.1\|WP_086056868.1\|1560012_1561140_+\|polyamine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|183226
NZ_CP021110.1\|WP_086056857.1\|1546947_1548090_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143500
NZ_CP021110.1\|WP_086056860.1\|1552075_1552492_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180236

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086056869.1\|1561136_1562057_+\|ABC-transporter-permease-subunit	gnl\|CDD\|182646	PRK10683, PRK10683, putrescine transporter subunit: membrane component of ABC superfamily; Provisional.	4.79765e-124
NZ_CP021110.1\|WP_086056874.1\|1564885_1566256_+\|DNA-recombination-protein-RmuC	gnl\|CDD\|224241	COG1322, COG1322, Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only].	5.89162e-96
NZ_CP021110.1\|WP_086056866.1\|1558059_1558779_+\|3-deoxy-D-manno-octulosonic-acid-kinase	gnl\|CDD\|234975	PRK01723, PRK01723, 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed.	2.26813e-89
NZ_CP021110.1\|WP_086056872.1\|1563220_1563913_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|234840	PRK00802, PRK00802, DNA-3-methyladenine glycosylase.	2.79231e-69
NZ_CP021110.1\|WP_086056861.1\|1552799_1553219_-\|hypothetical-protein	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.58283e-14
NZ_CP021110.1\|WP_086056867.1\|1558906_1560007_+\|polyamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270377	cd13659, PBP2_PotF, The periplasmic substrate-binding component of an ABC putrescine transport system and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic substrate-binding domain that serves as the primary polyamine receptor of ABC-type putrescine-preferential transporter from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.17525e-161
NZ_CP021110.1\|WP_086056862.1\|1553204_1554113_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	7.64984e-121
NZ_CP021110.1\|WP_086056873.1\|1563964_1564714_-\|hypothetical-protein	gnl\|CDD\|378479	pfam10707, YrbL-PhoP_reg, PhoP regulatory network protein YrbL. This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner.	2.42449e-67
NZ_CP021110.1\|WP_086056871.1\|1562850_1563207_+\|arsenate-reductase	gnl\|CDD\|239333	cd03035, ArsC_Yffb, Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.	9.09838e-51
NZ_CP021110.1\|WP_086056859.1\|1548993_1550370_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP021110.1\|WP_086056858.1\|1548250_1548967_+\|SDR-family-oxidoreductase	gnl\|CDD\|181044	PRK07577, PRK07577, SDR family oxidoreductase.	3.7243e-149
NZ_CP021110.1\|WP_086056865.1\|1557308_1557737_+\|group-II-truncated-hemoglobin	gnl\|CDD\|381282	cd14773, TrHb2_PhHbO-like_O, Truncated hemoglobins, group 2 (O); Pseudoalteromonas haloplanktis PhHbO like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb2's belonging to this group include Pseudoalteromonas haloplanktis PhHbO (encoded by the PSHAa0030 gene) which appears to be involved in oxidative and nitrosative stress resistance.	4.59e-61
NZ_CP021110.1\|WP_086056875.1\|1566338_1567016_+\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	1.31258e-120
NZ_CP021110.1\|WP_086056870.1\|1562053_1562854_+\|ABC-transporter-permease-subunit	gnl\|CDD\|182574	PRK10592, PRK10592, putrescine transporter subunit: membrane component of ABC superfamily; Provisional.	6.54856e-106
NZ_CP021110.1\|WP_086059324.1\|1550979_1551885_-\|hypothetical-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	0.00049565
NZ_CP021110.1\|WP_086056864.1\|1554759_1557312_+\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_CP021110.1\|WP_086056868.1\|1560012_1561140_+\|polyamine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|183226	PRK11607, potG, putrescine ABC transporter ATP-binding subunit PotG.	5.86555e-163
NZ_CP021110.1\|WP_086056857.1\|1546947_1548090_+\|alanine-racemase	gnl\|CDD\|143500	cd06827, PLPDE_III_AR_proteobact, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases. This subfamily is composed mainly of proteobacterial alanine racemases (EC 5.1.1.1), fold type III PLP-dependent enzymes that catalyze the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. hese proteins are similar to other bacterial ARs and are fold type III PLP-dependent enzymes containing contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	0
NZ_CP021110.1\|WP_086056860.1\|1552075_1552492_-\|hypothetical-protein	gnl\|CDD\|180236	PRK05753, PRK05753, nucleoside diphosphate kinase regulator; Provisional.	2.04985e-31

>NZ_CP021110.1|WP_086056865.1|1557308_1557737_+|group-II-truncated-hemoglobin
MTTTTRVQPIFEPLDHTRTIFEQLGGEPAVRELVNRFYDLMDIEEDFAALRAAHGPSLDAAREKLFLFLCGYFGGPDHYVQKYGHPRLRARHLPFSIGEAERDQWVACMGRAMQDMNVPAPLMDRLLHAFYGTADWMRNRAG
>NZ_CP021110.1|WP_086056864.1|1554759_1557312_+|FtsX-like-permease-family-protein
MQDTSAARLDAAIPASAPTGLSHSLRLGVRALLRDWRAGELRLLVIVLIVAVAAVTSVGFLADRVGRALERNAAQMLGADIVLDADEPIPAAFERRAREQGLRLARTYQFPSMASAGQSSQLVSLKAVEAGYPLRGGLRTAAEPAGLETATRDIPEPGTVWVDAQVLSALGVRMGDRIALGDSQFRIARVLTYEPDRGMQFVNLSPRVLMRADELAATHLLAPGSRVGYGLLAAGDASAVAAYSQWLQAHLQRGQKIATVESGRPEIRRMLDRAQRFLSLVALLAVLISAVAVALAATRFMVRHRDGIAIMRCLGATQAQIARMLAAEFLMVGLIASLVGGMFGYMAHLGLIAALGRMLDADLPSPSMVPGIQGLATGLWLLLGFALPSLAQLRHVPPARVLRRDVGLLRPGSAAGYAVGAAGFALLIWWFAGDAMLGVVIAGGFLGAFAAFALVALLCVQALARLRRAAGGMPALRFALAGLVRRRAASVTQVCALAIGLMALLLLTMTRTDLVAGWQRTLPQDAPNRFLINIQPDQREPVAAALRQAGVGDVTLFPMIRGRLVAVNGRPVSASDYAEERARRLVDREFNLSYSATMPSYNSLQAGRWMSADSREVSMESGIAATLGLGMGDKLTFDIAGQSVEVTVTSLRGVDWDTMRANFFAMLSPGVLADAPQSWITAFHLPSGQRELLPRLVQRFPNLTVFDVDAILRQLQGVLDQVVQAVQLLFGFTLAAGVLVLTAALAATRDERVREAAVLRALGATRRQLARAQRIELLAVGGLAGLLGAAGAGAVAWALSRHVFDFDITFSLWPWLAGVAVGMLGAWAGGALALRGVLRTPPLVTLREAL
>NZ_CP021110.1|WP_086056863.1|1554358_1554556_+|hypothetical-protein
MTNRSRIAAFLSASALCLGLTAAPAVFAAEAGSANAKPAKAHTHKHKAKSGATAKKSAAPAPAAK
>NZ_CP021110.1|WP_086056862.1|1553204_1554113_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MDDVHLDAGMRSHGPPTAAGGGTDIVARIIAEKIAPVLGQPIVVNNKPGAGGTIGNQYMLRERNDGYTLFVTANSNQLIVPWIFKDAGFDPIKDFTPVSGLGVVPYVLAVNKSFPAKTLNEFLDLIKKEPGQIYYASAGAGTLNHLIPEMLASHIGTKMEHVPYKGVAPAMTDVLGGQVPVLFGSLSSVLENIKSDNLRALGVTSAHRLELLPDVPAIAEAVPGFKAEMWVALYARAGTPQHVVDRLREAVHVALKDPDTQARFKQLGMQVMDVGPRQLAEMQEKEYAMWGDIVEKSGASAR
>NZ_CP021110.1|WP_086056861.1|1552799_1553219_-|hypothetical-protein
MNVVHSEPFGFVTRREQASAGGPVSPKQLARHRLIGYDKTQSPYLRDLFENLLKRLPSPPEIVQESRLPSILTLVEAGMGAAVVPWSMVKAKTSSLRFHKIELSPAPTAQIVVASVPRRAGVTAQAFVADFLSRRSDRA
>NZ_CP021110.1|WP_086056860.1|1552075_1552492_-|hypothetical-protein
MHVSAEERVLSELDHARLVGLLTRLTASRHDDATQDAHDLLVTAPTVPGPAVPPDLVTMRTRLLLRGEDNGEQELTLVYPAEADAAHGCISVLSPLGLSLIGCREGQTIQWQGRDRVVHTSTIAKILYQPEAAGDYGT
>NZ_CP021110.1|WP_086059324.1|1550979_1551885_-|hypothetical-protein
MDITKAFIKAKQPCADGYRWYLRNARADDSYQQLLDALVADGRVGDACWLLDQFGPTDAVCVLDDIEAHAIVFAGTLHVRGSVRVDTVLRVGRDLRVDGGIRANRVTSGGEIRCGAALSCDAAIAAGGDLLVAWNLDAAGAVSAERLRVGWDLTGGAGLRARADVWVGGSLHLHGPLDGLAGVRVGEDMECAAAITVKHGVECGATLRCAGHIHAGWGIRASGSILAEGAIRAGESIRAGEEIRAGPGYGIYAGLDVRDDAWETSAQVRARRRPVQLHSGWWAGPDETACSPNDAASACPT
>NZ_CP021110.1|WP_086056859.1|1548993_1550370_+|DNA-repair-protein-RadA
MAKSRTVYVCAECGGTSPKWQGKCPHCNAWNTLEETVETAAPAAAASHRYAPLASSSPVRSLAEIEAREVPRQPTGLDEFDRVLGGGLVAGAVVLIGGDPGIGKSTLLLQALASLSESTRVLYVTGEESAEQVALRARRLGLTTGNVDLLAEIRLEAIQAAVTEQKPAVAVIDSIQTLYSGELTAAPGSVSQVRECAAQLTRLAKQTGIAIVMIGHVTKDGALAGPRVLEHIVDTVLYFEGDTHSSFRLVRAFKNRFGAVNELGVFAMTDRGLRGVANPSALFLSQHDRQVAGSCVMATQEGTRPLLVEIQALVDGVQGSNPRRLTVGLESNRLAMLLAVLHRHAGVVTSDQDVFVNAVGGVRITEPAADLPVLLSIMSSLRDRPLPRGMVAFGEVGLAGEIRPAPRGQERLREAAKLGFNVALIPKANAPRQPIEGLEVWAVDRLEHALDRLKNGAG
>NZ_CP021110.1|WP_086056858.1|1548250_1548967_+|SDR-family-oxidoreductase
MKDKCVLVTGATKGIGWALTRRLADMGCHVVGIARNTSDVDFPGYLYACDLADAGKTEEVLREIRDKYPVDAVVNNVGLVLPQPLGSVELASLFNVLDLNVRVAVQVAQAFVENMKARRAGRIVNVVSRAIYGGYERTSYSAAKNALVGCTRTWALELAEYGITVNAVAPGPIETELFRASRPVGSDAEKRILSTIPMKRIGSPADVAAAIAFLLSDDAGYITGQVLSVDGGGSIAGR
>NZ_CP021110.1|WP_086056857.1|1546947_1548090_+|alanine-racemase
MPRPISVTISVSALAHNLAVVQRHLEQAAAAARGRGNACKTPSIWAVIKAHGYGHGTAQAARGFANANGLAMLDLAEAVECREAGWTKPILLLEGFFEPADLEILDRYRLTSVVHTREQLDMLAGHRPSRPLNVFVKLNSGMNRLGFAPHAYRDAFARAQALREQGVLGAVGRMTHFANADAPEGVASQLEVFQRTAGDLPGPVSLSNSAATLRYPEIALARPDGESWVRPGICLYGASPFFDTDAASFGLRPAMSLRSQIIAVQHLQPGDAVGYGSLFTADRPLRTGVVACGYADGYPRHAGTGTPIVVAGVRTRVLGRVSMDMLCVDLTPVPDAGIGAPVSLWGADGPSVDEVAQAAGTIGYELLCALAARVPVRSVA
>NZ_CP021110.1|WP_086056866.1|1558059_1558779_+|3-deoxy-D-manno-octulosonic-acid-kinase
MGAEMLRVAWQGKRPGAMCYDAMQVPRADPAMFDPAYYGARAEPVAVGGRQSAWFVDGDCGPAVLRHYRRGGMVARISRQRYIWLGEARTRCFREFRLLESLAAQGLPVPAPLAAAYWRVGALTYEAAILVRRLPDVRPLARMLQEPVWDAAADAIARMHQAGVWHADLNAYNILLDARGKAWIIDFDRGRQGGVSGPAKRRNMERLQRSLVKVGGAAGQAFFERLNQAYQNRMARAPA
>NZ_CP021110.1|WP_086056867.1|1558906_1560007_+|polyamine-ABC-transporter-substrate-binding-protein
MGINARARLAAGALMALTALSAKAQENVVNVYNWAEYTAPDTIPGFEKETGIKVRYDTYDNNDTLQAKLLTGKSGYDVVVPSTHYASRQLQGGLFQPLDKDKMPNLKYLDPDVMALVAQVDPGNKYFVPWGYGTNGLGYNVTKVQAIMGKDAPLNSWDMLFKPENAAKLKDCGISVLDEAAQVFPAVLHYLGKDPNSTNPDDYKAALDVLKQIRPYIRQFSSSGYIDEMASGDLCMVYGFSGDVMIARDRAKQNKQSFEINYVIPQGGAPAWFDVMAVPKDAPHPENAMKFINYIETPQVHAAITNKMFYPNANKEARKYVVPEVADNPMIYPPADVSKTLYVIKAQPINILRLQTRMWAELKSGR
>NZ_CP021110.1|WP_086056868.1|1560012_1561140_+|polyamine-ABC-transporter-ATP-binding-protein
MNDSRYAAPHAADADEFVRVCDLVKIFGDTVAVRSVNLAVRRNELFALLGSSGCGKSTLLRMLAGFEEVTSGQILLDGEDITNVPPYRRPVNMMFQSYALFPHMSVEANVAFGLKQEGVDRAEIHDRVFEALNLVQMAGYSRRKPHQLSGGQQQRVALARSLVKRPKLLLLDEPMSALDKQIRQNTQIELVRILEQVGVTCIMVTHDQEEAMTMAHRLAVMTEGQIVQVGTPQDVYEFPNSRFVAGFIGSTNLFSGTIVVDEPDHVAIESDQLSRHLYVSHGVSEPLGMPVHVSIRPERIVVSREQPDSAYNWAHGAVTHMAWMGSYALYHIRLDSGATVEATVPRRVFEKTEAPAVHEEVYVSWDADSATVLPS
>NZ_CP021110.1|WP_086056869.1|1561136_1562057_+|ABC-transporter-permease-subunit
MNGSLLRRLLPSSRALAVVPPFAWLALFLLVPFLLVLKISFADLQFGVPPYTPLVELKDEALNFSLHLRGYALLFTDSLYLATYLSSVKIAAISTVCCILIGYPMAYYIARSNPETRNILLLGVILPFWTSLLLRVYAWVGILRNDGLLNKLLLGLGIISQPLEIYRTDLAVYIGMVYSYLPFFILPLYANLVKMDLRLLEAAYDLGARPWQAFWQITVPLSRPGVIAGAMLVFIPAVGEYVIPEMLGGANTLMMGRVMWSEFFNNADWPMAAAVTCVMVLLLLVPLALFQYNQVRQVEMMREGKL
>NZ_CP021110.1|WP_086056870.1|1562053_1562854_+|ABC-transporter-permease-subunit
MKGPHRGMRALALGLGFAFLYIPILSLVVFSFNDSPLVTSWSGFSFKWYASLFHDDALLSAAWLSFRVAALAATAATVIGTWAGYILARMGRFRGFSLYIGMLSAPLVIPEVVIGISLLLMFVEVRSTIGWPENGIFTIWVGHTTFCMAFVAVIIQSRVRDLDRSLEEAALDLGATPLKVFFTITLPLIAPALASAWLLSFTLSLDDVILSSFLSGPGYTTLPIEVFSRVRLGLKPEVNALAALFILTVGICVVVANRLQRRKESA
>NZ_CP021110.1|WP_086056871.1|1562850_1563207_+|arsenate-reductase
MNLPILYGLKQCSTCVKARTWLDEHGIEHEFIDYRDHPVPPATLKAWAEQLGGWEKLVNRTSMTWRALPESRKSASTDAQWQALIAEYPALVRRPVTVTPDGAVAVGFSEKRYSERFA
>NZ_CP021110.1|WP_086056872.1|1563220_1563913_+|DNA-3-methyladenine-glycosylase
MLPDSFFDRDAQQAARELIGMVLRRRHGDLWLSARIIETEAYYLHDKGSHASLGYTHKRRALFMDGGAIYMYYARGGDSLNISAGGPGNAVLIKSAHPWLDAVSGEDSLARMQALNPDAQGRSRPPQRLCAGQTLLCRALGLKVPEWDGGRFDPSSFFVEDIGARPRRLIRTVRLGIPEGRDAHLPYRFVDPAYAPFCTRNPLRRGQVAGRDYDWITRQGRPCKGQADPA
>NZ_CP021110.1|WP_086056873.1|1563964_1564714_-|hypothetical-protein
MSIVSLPARRDFAAPPLASLAPLPVAGETFAPFDMLDLAGLRPIASGAERLVYQHPTHPSLLVKVVDLAELADHLSTRPLRRWRKNLQRDGAYRNHIAELAEYAAAQHAAAGRWKIPMARMLGLAQTNLGLGLLVEKITDGQGGLAPTVEQIVRERGLDETLARELDNFFDALADHHVVLNDVSARNVVMGLNADGETGLYLIDGFGSKQAIPLFAYSKTLNRRRIQRKYRMLRAKLQARSLARPQLHD
>NZ_CP021110.1|WP_086056874.1|1564885_1566256_+|DNA-recombination-protein-RmuC
MPQSDILLLSWVGAAAAVVAAVAAIVAAWRAGRSTGVGVRLEALAAEQERTARELRLELSESQRGLRVELGQQLDALRGGIARDAQAARTESAESLARFGAAFGEQVQRLIDLNDRRMQEVRQTVEQRLQALQSDNAGKLDEMRRTVDEKLHATLEQRLGESFKLVSDRLEAVHKGLGEMQSLASGVGDLKRVLTNVKSRGTWGEVQLARLLEDTMTPDQYACNVKPVPGSDAIVEFAIRLPGRAEGGAPVWLPLDAKFPKEEYERLIEAEQAADPDGARNAAAALARAVELQAKSIAAKYIAPPHTTDFAIMFLPTEGLYAEVLRRPGLLDKLHGMRVNVAGPANLAALLNSLQMGFRTLAIERRSSEVWQVLRAVKTEFGRFGEALAGVKRTLDTASSKIGQTEVRTRAMLRSLKAVEALPGDAPGAGAGGPEQGGNGLATTVFDADDDEAPQA
>NZ_CP021110.1|WP_086056875.1|1566338_1567016_+|ribose-5-phosphate-isomerase-RpiA
MLSQQELKQQAATAALEFVEEVAGADVVIGVGTGSTADLFIDGLARFKEKLRGTVASSTRSAQRLQALGIPVLDLNDVERMPIYVDGADEIDGNLHMIKGGGGALTREKIVASVADRFICIADESKLVERLGTFPLPVEVIPMARAAVARQLASMGGRPALREGFVTDNGNVILDVSGLPITDAAALELRINNLPGVVTCGLFTQPGAHVALLATQQGIRRLSRP

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Crispr_ID: NZ_CP021110_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_4

2507635-2507721

Orphan

Consensus_repeat	Method
CGAGGGGGCGCGCCTGCGGACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_4

>merge|NZ_CP021110|4|2507635-2507721|CRISPRCasFinder
CGAGGGGGCGCGCCTGCGGACCGGGGGGGAACCCCACCCCCAAGCGCTATCGCGCTTCCCCCTCCAGGGGGCGCGCCTGCGGACCGG

>NZ_CP021110|4|4|2507635-2507721|CRISPRCasFinder
CGAGGGGGCGCGCCTGCGGACCGG	GGGGGAACCCCACCCCCAAGCGCTATCGCGCTTCCCCCT
CCAGGGGGCGCGCCTGCGGACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086057614.1\|2518513_2519383_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP021110.1\|WP_086057600.1\|2499272_2500058_-\|phytanoyl-CoA-dioxygenase	unknown	unknown	gnl\|CDD\|227609
NZ_CP021110.1\|WP_086059423.1\|2511297_2512245_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP021110.1\|WP_086059424.1\|2513519_2514836_-\|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NZ_CP021110.1\|WP_086055842.1\|2509163_2510120_-\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP021110.1\|WP_086057608.1\|2506848_2507514_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
NZ_CP021110.1\|WP_086057603.1\|2501438_2502131_-\|4-carboxy-4-hydroxy-2-oxoadipate-aldolase/oxaloacetate-decarboxylase	unknown	unknown	gnl\|CDD\|181735
NZ_CP021110.1\|WP_086057605.1\|2503311_2504205_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182137
NZ_CP021110.1\|WP_086057610.1\|2510322_2511291_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP021110.1\|WP_086057609.1\|2508034_2508712_-\|DNA-oxidative-demethylase-AlkB	unknown	unknown	gnl\|CDD\|237957
NZ_CP021110.1\|WP_086057602.1\|2500657_2501236_-\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
NZ_CP021110.1\|WP_086057613.1\|2518098_2518482_+\|DUF423-domain-containing-protein	unknown	unknown	gnl\|CDD\|225238
NZ_CP021110.1\|WP_086057607.1\|2504855_2505914_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP021110.1\|WP_086057612.1\|2516768_2518001_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP021110.1\|WP_086059422.1\|2506018_2506819_-\|iron-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270244
NZ_CP021110.1\|WP_086057611.1\|2512358_2513516_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP021110.1\|WP_086059425.1\|2514832_2516437_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|227319
NZ_CP021110.1\|WP_086057601.1\|2500127_2500661_-\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
NZ_CP021110.1\|WP_086057604.1\|2502195_2503191_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP021110.1\|WP_086057606.1\|2504261_2504666_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|366663

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086057614.1\|2518513_2519383_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.75083e-11
NZ_CP021110.1\|WP_086057600.1\|2499272_2500058_-\|phytanoyl-CoA-dioxygenase	gnl\|CDD\|227609	COG5285, COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism].	9.18117e-35
NZ_CP021110.1\|WP_086059423.1\|2511297_2512245_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.79512e-33
NZ_CP021110.1\|WP_086059424.1\|2513519_2514836_-\|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	5.27753e-112
NZ_CP021110.1\|WP_086055842.1\|2509163_2510120_-\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.48556e-21
NZ_CP021110.1\|WP_086057608.1\|2506848_2507514_-\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.23739e-94
NZ_CP021110.1\|WP_086057603.1\|2501438_2502131_-\|4-carboxy-4-hydroxy-2-oxoadipate-aldolase/oxaloacetate-decarboxylase	gnl\|CDD\|181735	PRK09262, PRK09262, hypothetical protein; Provisional.	2.07537e-136
NZ_CP021110.1\|WP_086057605.1\|2503311_2504205_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	2.79088e-62
NZ_CP021110.1\|WP_086057610.1\|2510322_2511291_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	4.40483e-155
NZ_CP021110.1\|WP_086057609.1\|2508034_2508712_-\|DNA-oxidative-demethylase-AlkB	gnl\|CDD\|237957	PRK15401, PRK15401, DNA oxidative demethylase AlkB.	8.7675e-136
NZ_CP021110.1\|WP_086057602.1\|2500657_2501236_-\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	6.50353e-32
NZ_CP021110.1\|WP_086057613.1\|2518098_2518482_+\|DUF423-domain-containing-protein	gnl\|CDD\|225238	COG2363, COG2363, Uncharacterized small membrane protein [Function unknown].	1.92607e-29
NZ_CP021110.1\|WP_086057607.1\|2504855_2505914_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.13663e-45
NZ_CP021110.1\|WP_086057612.1\|2516768_2518001_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.11744e-64
NZ_CP021110.1\|WP_086059422.1\|2506018_2506819_-\|iron-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270244	cd13526, PBP2_lipoprotein_MetQ_like, The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold. This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	5.02607e-74
NZ_CP021110.1\|WP_086057611.1\|2512358_2513516_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	9.01499e-80
NZ_CP021110.1\|WP_086059425.1\|2514832_2516437_-\|ABC-transporter-permease-subunit	gnl\|CDD\|227319	COG4986, COG4986, ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism].	0
NZ_CP021110.1\|WP_086057601.1\|2500127_2500661_-\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	5.17419e-30
NZ_CP021110.1\|WP_086057604.1\|2502195_2503191_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.55252e-138
NZ_CP021110.1\|WP_086057606.1\|2504261_2504666_-\|transcriptional-repressor	gnl\|CDD\|366663	pfam01475, FUR, Ferric uptake regulator family. This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.	6.08396e-43

>NZ_CP021110.1|WP_086057608.1|2506848_2507514_-|carbonic-anhydrase
MDKTFDFPGRLTAGYQAFLTSRFPSERARFRQLAEVGQSPEIMVIGCCDSRVAPELIFDAGPGEIFVLRNVANLVPPYEPDSHYHGTSSAIEFAVNGLNVKHIVVMGHAACGGIRSYYDHAEPLAKGDFIGKWMSQIGETANKLNLGGERDADLRRLEWAVVEHSLNNLMTFPYIRQRVERGELQLHGAYFGVATGLLFIRDPRTGDFHPFGEGPADDSAA
>NZ_CP021110.1|WP_086059422.1|2506018_2506819_-|iron-ABC-transporter-substrate-binding-protein
MLRGLGAAAGLAWVPAVTRAIAQPAPLRIGVIASIANEATEIAIDQARLEGVNARLVEFADWVMPNVATVDGSIDANFFQHAPFLDVFNRSRGANLVPIAYGYSTTIGLFSKKIKRGEPIPQGASIGIPADPVNTGRALLLLQSMGLIVLKPGVAERATLLDVQDNPRNLKFVAIEGAQASRSFDDVTASVTYTTFARHGGLDEKEGLAFDNQDPVNVRRYAIRWVTRPERAQDQRLLKFIAVYQRSPEVKATLRRLYGDLIDFPW
>NZ_CP021110.1|WP_086057607.1|2504855_2505914_+|AI-2E-family-transporter
MSNSNLHYRTFLFLLIVVTIAFGWILWPFYGAVFWGTILAIIFAPLHRRLLSRLGKRRNLAALITLLLCVVIAILPVIVITGSLVQEGTALYQQIRSGNLNFGLYFERVMNALPPSVHATLDRFDLADIRSLQEKLSTATVQGSQFLATKAFSIGQDTFQFVVSFGVMLYLLFFLLRDGATLSRTISRAIPLSEAYKQHLTRKFTTVIRATVKGNVAVAATQGLLGGLAFWFLGIQGSLLWGVLMGFLSLLPAVGAALIWVPVAVYFLVTGALWEGLGLIAFCVLVIGMVDNIMRPILVGKDTKMPDYVVLISTLGGMALFGLNGFVIGPLVAALFTAVWDLFASEGETAAN
>NZ_CP021110.1|WP_086057606.1|2504261_2504666_-|transcriptional-repressor
MTDSVDLKGIGLKVTFPRLKILDLFRNSERRHLSAEDVYRHLMNEGVEMGLATVYRVLTQFEQAGLLKRSQLGGNKAIFELNDGERHHGHLVSTPTGHVEEFFDPDIERRLRQIADEMGYNLTEFTITIFATPK
>NZ_CP021110.1|WP_086057605.1|2503311_2504205_+|LysR-family-transcriptional-regulator
MDFRQLRYFVAVAEELSFSAAARRLHVSQPPLSMQVKSLEDELGATLLRRTKRHVELTEAGALFLEQARRALQHLERAGDVVRQAMQGEAGEIRIAFTASVPMFEAFPRIVQSFRSRHPAARADLLHMSTGQQLQALAERNIDVGFLRPSLLFCPPPDIRVLSLWSDRLMAVLPAGHRLAQRRAPLPMAALSGESFILFPRGLGCGLFEHVGVLASRAGFALQVSQEAREGATIIGLVAAGMGVSILPETYAKTGIPGVTYRPLDTPDAASRVLLAHRADDDTPLLARFFETAAASR
>NZ_CP021110.1|WP_086057604.1|2502195_2503191_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MRACSALSKLIRGLGVAAALVATAAPGLAHAASDYPSKPIRIVVPYAPGGAVDIVTRLVAQKMGESLKQSIIVDNRPGGATNIGMDLVARAPADGYTLLTASNSLASNGALFTKLNFDPSKDLLPVGAIGYAPLVVVVSSSSQFKTLQNLIDYGKANPDKLTYASAGNGSSGHLASELLKDEGKFNALHVPYKGGAPAITDLLGGRIDFMSINPVEAIPHIKADKMRPLAVMDSKPAAMLPNVPTVSSLGLGGAAASVWWGFCAPKGTPDDVVAKLNEALNQALADENVKTRLSELGAVATPGSTADFTKFVQDETAKWSRVIKNANIKAD
>NZ_CP021110.1|WP_086057603.1|2501438_2502131_-|4-carboxy-4-hydroxy-2-oxoadipate-aldolase/oxaloacetate-decarboxylase
MTYAVRNIERADRDLIARLGAAGTATVHEAQGRSGLLQPYMRPVYAGAAIAGSAVTVLAHPGDNWMLHVAIELCQPGDVMVVACSAPNTDGMFGELLATSMRARGIAGLVIDAGCRDVQALKDMRFPVWSKAISAKGTIKATPGSVNLPVVCAGAMVSAGDVVVADDDGVVIVPRRRAAAVAQACDARLQKEALNRKRLAAGELGLDIYGMRDKLREAGLVYVDSEADLP
>NZ_CP021110.1|WP_086057602.1|2500657_2501236_-|chromate-transporter
MKPAPDQAVRAIEPLAEPPTLAQLFTGFFVLGMTAFGGALPLARRMMVEKHRWISGEEFTTLLGLCQFLPGGNIINLSVAIGMRFRGVTGAVTALLGFVLVPTLVVIMLGVVYDHYQHDPHVRHLFAGLAAAAAGLLISLTLKIGAPLLRNRWGLIVALLCFLAIAVLRLPLLPTMLALTPLSILITWRKRS
>NZ_CP021110.1|WP_086057601.1|2500127_2500661_-|chromate-transporter
MTEVLIQLTVLFTELSLLAFGGGNTILPEMQRQVVDVHHWMTAENFTSLFALAQAAPGPNLMIVPLVGWHIAGWPGMLVSSFAKFGPSSLVTILVLRLWDRFKDKPWRAVAQQGIFPVTVGLVGASAALITAASVDGWLLSGIAAAVAVLGWRTRLHPLWLLLGGGLIGLVALNGST
>NZ_CP021110.1|WP_086057600.1|2499272_2500058_-|phytanoyl-CoA-dioxygenase
MSSSLTPAQLDTLKQQGFVVARSFAPAGRCEALRAVALEQLAEARAPVEYEADLAYPGAPASRQAEGGATVRRLLDAYARHPLFAEWATSPAVAAIMRAYFGESAVLSRAHHNCVMTKHPRFGSLTGWHRDIRYWSFEREDLVSTWLALGEETSDNGGLWLVPGSHVMELPAHRFDAAQFLREDLPENAALIGTAVCPRLEPGDVLFFHCRTLHAAGRNQSDRVKLSVVHTYHAASTHPHPGTRSASKPEIPLNDAGASAP
>NZ_CP021110.1|WP_086057609.1|2508034_2508712_-|DNA-oxidative-demethylase-AlkB
MAYPSLPGASGDLFGAPDEEAPWDEPIAPGAVLLRRYACGRAPALLAAVKAIAAAAPFRHLETPGGQRMSVAMTNCGTQGWISDRRGYRYGAEDPLSGRPWPAMPDVFIDLAREAAARAGYADFAPQACLINLYRPGARLSLHQDRDELDLRAPIVSISLGLPAVFLFGGLQRNDRPRRFTVQHGDIAVWGGPSRLAFHGVAPLRDGTHPATGPSRVNLTFRKTA
>NZ_CP021110.1|WP_086055842.1|2509163_2510120_-|transposase
MSEATYVGIDVSSEVLEIAVSTQPSTWQASNDSGGIEQLAGQLQALRPALVVLEATGGYEFEAACVLQAQGLAVAVVNARMARDFARAMGALGKTDALDARMLATFARVLDQHPDRARFVKPLADAQLQRLQALVLRRRQIVQTMTSERHRLRISHEAARPSIERHLAFLRQELDDSDGHIAEHVQQHQAELARVLSSVPGIGAASVALLLAELPELGRLDRRRIAALVGVAPVNRDSGKMRGQRSIWGGRASVRCALYMASLSAVRYNPVLRAYYQRLLGTGKKKKVALVATMRKLLTILNAMVRHNKQWEPALDCP
>NZ_CP021110.1|WP_086057610.1|2510322_2511291_-|site-specific-tyrosine-recombinase-XerD
MASSAGSRPRSARRVKQDAPSLQSRQDIDPSVAEFLDALWLEDGLSRNTLNAYRNDLAAFDVWLHEHEGRRICAARAGDIESWFAAVHGDTRPTTANRRLSALRRYFQWALRERRIASDPCLSVRSARQPLRTPKTLSEAQVEALLAAPRVETELGLRDKAMLETLYATGLRVSELVGLAALDVNLNEGVVRVVGGKGGKDRLVPLGAEAAHWIDRYVRHSRPLLLAGRQCDALFVTVRGEAMHRQTFWLMVGRYAKEADIRAPISPHVLRHAFATHLVNHGADLRVVQMLLGHADISTTQIYTHVARERLKTLHAQHHPRG
>NZ_CP021110.1|WP_086059423.1|2511297_2512245_-|hypothetical-protein
MKDIQTLLLAHGPLLVFLNVLLEQAGLPIPAYPLLVVAGALVLHGDLSWPLTLGAAVLACLIADAAWFAGGRRFGAGLLSTVCRVSISRDSCIRQTQSLYWRTGPRVLLVAKFLPGASALSTVMSGFAGLPFRTFLSYDAAGSLIWAGSALIVGIAFNDMVGVVLDALAEYGGYGLLAVAVALALYLTYRWIRRARTIRRFAHVRRVTLDELEEMRAAGCVPVLIDVRANSEQPLPGAVAVDPHVKAADGRFPWPLDAHIVVYCACPQEISAAVMADRLLKAGYRNVSALAGGYDAWVARQRTAQGPGEPAPSRG
>NZ_CP021110.1|WP_086057611.1|2512358_2513516_+|metallophosphoesterase
MRRPPIINRILAIGILVHLYIALRLLPDAPIPQAARWLGALYLALSCLLIPLGARARQLPPSWGRAAAWAGLLAMGFFSSLFVLTLLRDVLLFAVWAVDALRGVPADEAALRGSSALWVPVLALLLTLVGLFNARRRARIVTVNVPIAGLPPALDGFTIAQISDIHVGPTIRRPYVEAIVAAVNRMEADVVAITGDVVDGPVHQLAPHAAPLGQLRARHGVYLVTGNHEYYSGAREWVAEFERMGLCVLSNRHVVIAHGGTPLVLAGVTDYSAGQFDPAQRSDPRGALLGAPPDAAVRILLAHQPRSAFAAEPAGYTLQLSGHTHGGQFLPWNFFVRLQQPFTAGLRRLGRLWVYTSRGTGYWGPPKRVGAPSEITRIRLVPARP
>NZ_CP021110.1|WP_086059424.1|2513519_2514836_-|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein
MTMKAEKNLLDLSGVSKVFRTADGAIRSVLENVDFHLREGEIVALLGKSGSGKSTLLRIMAGLIPADQGSVHYRGQPLYGPAAGIAMVFQSFALFPWLTVRQNVALGLEAQGVPAAEREQRAEAALELIGLAGFGGALPRELSGGMRQRVGIARALATDPDVLLMDEAFSALDVLTGESLRDDMLELWEERRIGTRGILVVSHNIEEAVMMADRILIFSSDPGRVRDEIRVGLPRPRNAESAEVRALVDQVYSLMTAKPQPSAAAGAALPAVHQAYRLPDANVGTMEAVLELLAEPPLNGRADLPRLAEEAGLPDEELFPAYEALGLLGLAVVEQGDIALTPVGRRYAASEQQERQEIFGRQLLAHIPLAANICHSLQQEPTGELPEKQFLDVLEGFLKPDEAERVLKVAVEWGRYGEVYGYDYHTGRLHLPTAPASE
>NZ_CP021110.1|WP_086059425.1|2514832_2516437_-|ABC-transporter-permease-subunit
MAKPYAVGTPLPISLDPAYLPYYLLRTTLRMFMALGASLIFSFAFAAVASKSRVAEKILVPAVDILQSIPILGFLSITVTGFIALFPGRLLGVECAAIFAIFTSQAWNMALSLYQSIRTVPSELNEAARVFRLSGWQRFWRLELPYATPALLWNMMLSMSGGWFFVVASEAITVSNQDIKLPGIGSYIAVAIDAQNVRAIVYAIVAMAVGILLYDQLFFRPLLAWADKFRFEDAQSNTAQQSWLLDWLRRARLTRAWTEAVAQRAQGALGWFRRPYDGTSVRARSRGGNLHVQRAVDAILAALALIAVWRLAVFVHGEVGWGEVAHVFWLGLITLLRVLVLIAIASLVWVPVGIAIGLRPRWSQRIQALAQLLAAFPSNLLFPLAVIVIVAWKLNPEIWLSPLMVFGTQWYILFNVVAGATTIPSDLRYAADNLGLKGWLKWRRFYLPAVFPSFVTGAITASGGSWNASIVAEVVTWGNTTLTATGLGGYIADMTTRGDFPRIALGIGVMCIFVMGLNRFLWRRLYLLAEKWSR
>NZ_CP021110.1|WP_086057612.1|2516768_2518001_+|MFS-transporter
MSTTDGADRLVTRPAFAHFLLARFAASLAFQIVSVAVGWQIYALTGSALDLGLIGLAQFGPMLVLTLVVGHVADRYDRRRIVAICMAVEALAALVLAAVSLAGAANHLIVYAAIIAISSARAFEAPTLPALIPAVVPRALIPRATALSTSSNQVAQIAGPALGGVGYGLGAGWVYALAAVFYLAGLYSMLRMKTEGPPARKEPTTWRTLFAGFSFIASRRILFGTLSLDLFAVLLGGATALLPVFAKDILQAGPWALGALRAAPAVGAAAMALVLGRRSLDGNIGMTLFGALFVFGVATVVFGYSRSIPVSVAALAVLGAADAISVVVRSSLVQLNTPNEMLGRVSAINMLFVGTSNQLGEFRAGVMAAATGPVAAVVIGGAGTIAVAALWMWWYPELRRLRSLHNVPNT
>NZ_CP021110.1|WP_086057613.1|2518098_2518482_+|DUF423-domain-containing-protein
MTDRIFVFLGAINMFLAVGAGAFGAHGLRQVLSSEMLAVWQTGVTYHIAHALGLLALAALGARYGGTLWTLAGWLMFAGIVLFSGSLYLLSATGVRWLGAITPIGGAAFLVAWAIVAWAAWNPASGR
>NZ_CP021110.1|WP_086057614.1|2518513_2519383_+|DMT-family-transporter
MNAWRGIACILCGVLCLTVSDAIAKWLGSAYSPVQILFLRATIALPFVAGIVMMLGGRHALRTRHPGIHLLRGAINVISAVAFYTGLRYLPFAEATAISYAAPLCVTLLSVLLLKERVDAVQWTALVAGFAGVVLIVRPGSAGFDAAALLPLATAVLYAFMMITARAIGPGESVLTMGLYIVAAQLVCSALPLPWFWRTPDPSHWPFFAGVALFSTMGLTLITQAFRIAPASVVAPFDYMGLVWAALLGWMVWREAPDALTWLGALVIVVAGLTLILREAMRGERRAAT

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Crispr_ID: NZ_CP021110_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_5

2607527-2607626

Orphan

Consensus_repeat	Method
GAGGGGGAAGCGCGCCAGCGCTTCGGGGGTGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_5

>merge|NZ_CP021110|5|2607527-2607626|CRISPRCasFinder
GAGGGGGAAGCGCGCCAGCGCTTCGGGGGTGGGCTCTCCCCGCCGGTCCGCCAGCGTCGCCCCCTTGAGGGGGAAGCGCGCCAGCGCTTCGGGGGTGGGC

>NZ_CP021110|5|5|2607527-2607626|CRISPRCasFinder
GAGGGGGAAGCGCGCCAGCGCTTCGGGGGTGGGC	TCTCCCCGCCGGTCCGCCAGCGTCGCCCCCTT
GAGGGGGAAGCGCGCCAGCGCTTCGGGGGTGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086057680.1\|2594076_2594832_+\|flagellar-type-III-secretion-system-pore-protein-FliP	unknown	unknown	gnl\|CDD\|235566
NZ_CP021110.1\|WP_086057696.1\|2616263_2616680_-\|flagellar-basal-body-rod-protein-FlgC	unknown	unknown	gnl\|CDD\|235556
NZ_CP021110.1\|WP_086057683.1\|2596120_2599966_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372668
NZ_CP021110.1\|WP_086057690.1\|2609414_2610551_-\|flagellar-assembly-peptidoglycan-hydrolase-FlgJ	unknown	unknown	gnl\|CDD\|139173
NZ_CP021110.1\|WP_086057693.1\|2613440_2614202_-\|flagellar-basal-body-rod-protein-FlgF	unknown	unknown	gnl\|CDD\|183642
NZ_CP021110.1\|WP_086057689.1\|2607627_2609307_-\|flagellar-hook-associated-protein-FlgK	unknown	unknown	gnl\|CDD\|236165
NZ_CP021110.1\|WP_086059437.1\|2610563_2611631_-\|flagellar-basal-body-P-ring-protein-FlgI	unknown	unknown	gnl\|CDD\|235399
NZ_CP021110.1\|WP_086057685.1\|2601877_2603623_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|185008
NZ_CP021110.1\|WP_086057694.1\|2614234_2615443_-\|flagellar-hook-basal-body-complex-protein	unknown	unknown	gnl\|CDD\|235557
NZ_CP021110.1\|WP_086057679.1\|2593682_2594012_+\|flagellar-biosynthetic-protein-FliO	unknown	unknown	gnl\|CDD\|183160
NZ_CP021110.1\|WP_086057686.1\|2603707_2604196_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086057695.1\|2615527_2616223_-\|flagellar-basal-body-rod-modification-protein	unknown	unknown	gnl\|CDD\|183638
NZ_CP021110.1\|WP_086057687.1\|2604203_2606084_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|185001
NZ_CP021110.1\|WP_086057682.1\|2595165_2595954_+\|flagellar-biosynthetic-protein-FliR	unknown	unknown	gnl\|CDD\|235568
NZ_CP021110.1\|WP_086057681.1\|2594845_2595115_+\|flagellar-biosynthesis-protein-FliQ	unknown	unknown	gnl\|CDD\|235567
NZ_CP021110.1\|WP_086059438.1\|2616699_2617107_-\|flagellar-basal-body-rod-protein-FlgB	unknown	unknown	gnl\|CDD\|180196
NZ_CP021110.1\|WP_086057691.1\|2611911_2612607_-\|flagellar-basal-body-L-ring-protein	unknown	unknown	gnl\|CDD\|139164
NZ_CP021110.1\|WP_086059436.1\|2606138_2607371_-\|flagellar-hook-associated-protein-3	unknown	unknown	gnl\|CDD\|236345
NZ_CP021110.1\|WP_157664468.1\|2600026_2601661_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293741
NZ_CP021110.1\|WP_086057692.1\|2612606_2613392_-\|flagellar-basal-body-rod-protein-FlgG	unknown	unknown	gnl\|CDD\|183688

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086057680.1\|2594076_2594832_+\|flagellar-type-III-secretion-system-pore-protein-FliP	gnl\|CDD\|235566	PRK05699, fliP, flagellar biosynthesis protein FliP; Reviewed.	8.17787e-124
NZ_CP021110.1\|WP_086057696.1\|2616263_2616680_-\|flagellar-basal-body-rod-protein-FlgC	gnl\|CDD\|235556	PRK05681, flgC, flagellar basal body rod protein FlgC; Reviewed.	1.9495e-72
NZ_CP021110.1\|WP_086057683.1\|2596120_2599966_+\|hypothetical-protein	gnl\|CDD\|372668	pfam13678, Peptidase_M85, NFkB-p65-degrading zinc protease. This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65 thereby down-regulating the NF-kappaB signalling pathway. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.	0.00946786
NZ_CP021110.1\|WP_086057682.1\|2595165_2595954_+\|flagellar-biosynthetic-protein-FliR	gnl\|CDD\|235568	PRK05701, fliR, flagellar type III secretion system protein FliR.	3.52313e-65
NZ_CP021110.1\|WP_086057693.1\|2613440_2614202_-\|flagellar-basal-body-rod-protein-FlgF	gnl\|CDD\|183642	PRK12640, flgF, flagellar basal body rod protein FlgF; Reviewed.	6.59953e-117
NZ_CP021110.1\|WP_086057689.1\|2607627_2609307_-\|flagellar-hook-associated-protein-FlgK	gnl\|CDD\|236165	PRK08147, flgK, flagellar hook-associated protein FlgK; Validated.	0
NZ_CP021110.1\|WP_086059437.1\|2610563_2611631_-\|flagellar-basal-body-P-ring-protein-FlgI	gnl\|CDD\|235399	PRK05303, flgI, flagellar basal body P-ring protein FlgI.	0
NZ_CP021110.1\|WP_086057685.1\|2601877_2603623_-\|HAMP-domain-containing-protein	gnl\|CDD\|185008	PRK15048, PRK15048, methyl-accepting chemotaxis protein II; Provisional.	6.12704e-130
NZ_CP021110.1\|WP_086057694.1\|2614234_2615443_-\|flagellar-hook-basal-body-complex-protein	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	2.09279e-141
NZ_CP021110.1\|WP_086057679.1\|2593682_2594012_+\|flagellar-biosynthetic-protein-FliO	gnl\|CDD\|183160	PRK11486, PRK11486, flagellar type III secretion system protein FliO.	9.54189e-24
NZ_CP021110.1\|WP_086057695.1\|2615527_2616223_-\|flagellar-basal-body-rod-modification-protein	gnl\|CDD\|183638	PRK12633, flgD, flagellar basal body rod modification protein; Provisional.	5.91344e-83
NZ_CP021110.1\|WP_086057687.1\|2604203_2606084_-\|HAMP-domain-containing-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	8.48239e-139
NZ_CP021110.1\|WP_086057690.1\|2609414_2610551_-\|flagellar-assembly-peptidoglycan-hydrolase-FlgJ	gnl\|CDD\|139173	PRK12713, flgJ, flagellar rod assembly protein/muramidase FlgJ; Provisional.	7.6935e-121
NZ_CP021110.1\|WP_086057681.1\|2594845_2595115_+\|flagellar-biosynthesis-protein-FliQ	gnl\|CDD\|235567	PRK05700, fliQ, flagellar type III secretion system protein FliQ.	3.0829e-28
NZ_CP021110.1\|WP_086059438.1\|2616699_2617107_-\|flagellar-basal-body-rod-protein-FlgB	gnl\|CDD\|180196	PRK05680, flgB, flagellar basal body rod protein FlgB; Reviewed.	1.12484e-60
NZ_CP021110.1\|WP_086057691.1\|2611911_2612607_-\|flagellar-basal-body-L-ring-protein	gnl\|CDD\|139164	PRK12700, flgH, flagellar basal body L-ring protein; Reviewed.	1.87407e-121
NZ_CP021110.1\|WP_086059436.1\|2606138_2607371_-\|flagellar-hook-associated-protein-3	gnl\|CDD\|236345	PRK08870, flgL, flagellar hook-associated protein FlgL; Reviewed.	2.53789e-112
NZ_CP021110.1\|WP_157664468.1\|2600026_2601661_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293741	cd16017, LptA, Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase. Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.	7.15973e-20
NZ_CP021110.1\|WP_086057692.1\|2612606_2613392_-\|flagellar-basal-body-rod-protein-FlgG	gnl\|CDD\|183688	PRK12694, flgG, flagellar basal body rod protein FlgG; Reviewed.	1.69088e-148

>NZ_CP021110.1|WP_086059436.1|2606138_2607371_-|flagellar-hook-associated-protein-3
MRLSTSTIYQSGLNGILRNESDVLALQQQISSGRRVVTPSDDPLAAGKAITAYQNLNITQTYASNREAANRSLGLESNALGSIVTTLTDVLTRVVQAGNGTMADEDRNSLATVLEQSRDALLALANSTDGNGQYLFSGTTGDAAAYVQDPNSGIISYNGSAGQRLVQVEQARQMAVSDIGTDIFARATPGTTEYIATAQPTNKGTVTFSSPSIVPGNASAGHNFQITFKTDATTGAMTYSVEDTTTNTVVQSDVPYESGAEIDLGAAKLALKGDPADGDTLTVTTAQSTGLDMFHTLNSLITTLRAPSDGNAAAQAQLTNMLATANKKLSINLDNVSTVQASVGARQNELDALDTMGSQRALTDNKTLTDLTKIDYYEAVSAMSMHQLALQASMAAFSAVKGTSLFSMNK
>NZ_CP021110.1|WP_086057687.1|2604203_2606084_-|HAMP-domain-containing-protein
MFANLKVRTSIILLLSLYLLAMLLSNGVAWLGLQSSNNKLDGVNTIYTDQVTNLYAGYSQVLRARQVLNNAYDKIQNNRVDEGMSDLSRAAGFKSEADKRMALFAQAPKLPETVEMAQAIVSAYKTYSDMVDGQLSALRSRSLDAFAASSKTSSSANQGLDRAMKTMLDYLDKTTDNMVAQGHDDFTLARIVTVAMIVFAIILTAACWLVLNRMVLRPLREAGSHFDRIAAGDLSQHIEVRSTNEIGVLFGAVRRMQESLTRTVAAVRRGVDEINVGAREISAGNTDLSSRTEQQAASLEETAASMEELASTVKQNAENARQANQLAASASDVAERGGSAVAEVVNTMQEISGSSRKISEIVSVIDGIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRSLAQRSAQAAKEIKALIEDSVSKVGAGSQQVERAGATMQEIVASVKRVTDIMGEISAASEEQSSGIDQVNRAVSQMDEVTQQNAALVEEAAAAAGSLQEQAQRLAEAVAVFKINEARVIDMPAREIPAAAAPRMPAPPSESAPAATSAEAPRLSHAPAAARSARPAPASQAPASPAAAKAPARAAAPARRAPAAANDGVAPRPAPKARAAGGTAAALNEDDWESF
>NZ_CP021110.1|WP_086057686.1|2603707_2604196_-|hypothetical-protein
MALTLRLIATWRPRLLASLAGLVLLGGCATGQNFSAESLASLQPGRTTMTDAIQTLRAMPQQVMPQSDGSTVAIWAYKMSVVADALYFRREAMLQFGADGRLARVLNTTNVPLSDATRQRLLGATSIPQEGPATPVAAANPQPETGAPGPGPGATAIPVRVQ
>NZ_CP021110.1|WP_086057685.1|2601877_2603623_-|HAMP-domain-containing-protein
MEAITETSRKAKASKRKAARQPKVKRKFSLRDTRVGTLLMFVLGIFALLIVAVGGMAAYFLNQNYRAVVELGQLTDRATQVQVINANMLRARVALLVSARDLQEASAEGVSPDAAANAKKDAADSLKSANDLLTAVRNSFGDFQKNMLEDDTGRQLSMNLVRRYRSYIDDGVDTMVEALRSQDYSTFYMVNTEYGTPRSAAFIDAIEDFSKYIKTSQTETAAQAKHNLDLALIAVAAAVGLAVILMILARVVFGRMVVRPLVEAGQHFDKIANGDLTQRVEVRSHNEIGTLYAALKRMQESLTRTVAAVRRGVDEINVGSREISAGNTDLSSRTEQQAASLEETAASMEELASTVKQNAENARQANQLAASASDVAERGGSAVAEVVNTMQEISGSSRKISEIVSVIDGIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRSLAQRSAQAAKEIKALIEDSVSKVGAGSQQVERAGATMQEIVASVKRVTDIMGEISAASEEQSSGIDQVNRAVSQMDEVTQQNAALVEEAAAAAGSLQEQAQRLAEAVAVFKINEGQVIDVPAQQLSGQVFTPPLVAQ
>NZ_CP021110.1|WP_157664468.1|2600026_2601661_-|sulfatase-like-hydrolase/transferase
MSDSSSHGASGIPGWRARAVSSVSACALIECLAFAYVAVVFPALDGFYAIDRFRAIGVNVQGHLGPAEVLRQAVFILEYAFAVFMLYAATRLGRWRSTGVLALFVPLLTLDLAAHAIYGRPAGIGNISALNASATMLGAALQEYGSIIAAAAGKALLLVAPLVVKAWIGHERRWSFVCPLLLAAALTAMYGTILVKRGPPALIGFPKGFSYALGSVYLKLNDVIGRPRRVPAQPMTAPEYPDIRNVVVVVDESVEYGYFSRVLDAGKSRYADFGLAYSGANCSAASNYILRKALWSRSDRGRLGIARTDSLFALARRAGYVVTYIDNQGVLSDPTTRNYIDAKELGDIDRVVENEGPPYERDATAVQQIAVLARTGRNFIFVNKNGAHFPYPASVAPDRATGDRVADYTTSVRVNAADFLLALQDAVPADTMVFYTSDHGQSLTTRATHCNTGAETTAQEFRVPFLVLATNAGPAQQLQQAATLQRGRLTHLEFSESVRRVLGYRIPGMGSIFDARAAQAGFCGLYGSPKVFFGMLPECRVLVR
>NZ_CP021110.1|WP_086057683.1|2596120_2599966_+|hypothetical-protein
MPTAVSPLASAAGQPLHNRADQPLSTRAPDDLVQLLPAQRQPPSTVAAGDATMPRHGHAIYENRRWRRDAPDARPATPPDSLPPGQPRAEDPWIAACRAGPVDTAYWNGRLEDDDALMVRLATASGGYAGTPSAADLTPAKRRELAVSLIRALTAGIDWQVSLGQAPNATAGIYFDGLTLRNASGKPMAGIVQELEARIAGVLQACGTAQLAGLTDCAGLARQVRRMMTSDPTLSLQPPPDVAYGSPRWVTLWTGMQTLADQGLSPHKVSTDDLVAVGRAAIAVQTRKSPRPAGSTTPPGVDIGALLLMAHAAGRIDLRRIAQEAPDSAADGAAAALAPEDLDRLTSFLKEIMADELRILDAIAGLKPPTGRELAADNLRAAGLDPEHRIDVRSVVIPAAFGPVRFKIPLPFAFDQQALADVYVSHETLDLSEDAGDPALSAPVSPEVSRARTKLGRSLKDEFDAAFDRYKTTAASHIATLIDASVARYGSDHGIDFAGATITVTRAQRVDSLHMPVVPGVGQGLLAVASASTERTDANGYFVSIDTSAGRHRYFVALSDGAEYPLPPERSIEDWAASHGEIVFGTAVHKPDFPGSLFNDLTYPLTTLATGKREEIGAQLNASLPGTLERSRAALYGASEVETIRGIERGLIPFYSTYSAIKDGRTEDIAWSLALDVLIFVPALGEGLSLGMRAGEALMAGLSRAVSETAGEGLLQAIKLGVAESGRFAPALMRQAGKTLGAVAHSAVIDPRDLLKLLRGGARLGNKGLRAVARSLKTSRPELAQALIEAARKMSAGGARYRPLPAGMLRRYRISDPGLIDTLSKAARSDDGTIMLGAKRYAEVEGNYLALTADHAASTQERPVWRIAGAGLPGTRQGGVRLVWDADLGRWQEAKNVPQLKGGGSTSASASTSASGSASATPAGTQLTRVKVADDAVAALDRDVPADAPNHRGDYDNWDNSEIYEYSYTGRLANTETVELAVEVLEEANDITQYAWWESEFDDFFDMEVVGLETSAYAEIDPRYADPETVKHLKITMTDRIRTFLTDLYARSETFRALVNRARSEGYIAKDDKWTIQIQPPDALSGGLCEFAEEHGADYEDRIVRIPDLQAPPQGLQDQMLADGYTWEPYLSPATIIHELIHVLTRRSDPAVDLWKDEASHLVHGFPERGVVEYLTQRVLKESGIQSPRQLTYLSYTSEGQANLARVITPEKIAALQRYVDMQDDYLLRRFPQHDPNPATPWNPSAGNERWLTADSLGSGSESDSGSESSSGSGSPEPMET
>NZ_CP021110.1|WP_086057682.1|2595165_2595954_+|flagellar-biosynthetic-protein-FliR
MISFTLDQWHGWINAFLWPFARLLALIGVAPVFGESSAPPLVKIGLAAILAVVIAPSLPPMPAVSPASYQGLWILAQQVFIGIATGFCMRVCFAAVQTAGDFVGLQMGLSLATIFDPTTQSNTEVLARLFNILAMLVFLSVNGHLLMLGMLVKTFTVLPIGTPVLNPEGWAAVAQLGSKIFSTGLLLALPLIAALLTIQLALGILNRAAPQLSVFAVGFPITLTAGVILLAVALPQSTGFLAAFFEESVNAMERVASLLAGI
>NZ_CP021110.1|WP_086057681.1|2594845_2595115_+|flagellar-biosynthesis-protein-FliQ
MDAETVMTMTYQAMRMVLIVAGPLLGVTLAVGLLVSVFQAATQINEMTLSFIPKLLAVAATLVLLGPWLIGMMTDYIRQIMDQIPTLVS
>NZ_CP021110.1|WP_086057680.1|2594076_2594832_+|flagellar-type-III-secretion-system-pore-protein-FliP
MRTAAITLAGLALLALACIPLSASAQAALPALTATPGPNGSETYSLSVQTLLMLTSLTFLPAALLMMTGFTRIIIVLGLMRSALGTQTTPPNLVLIGLALFLTAYTMSPVFDQIYKDAYQPFSEGAISFETAIERGSHPLRTFMLHQTRETDLSLFANLTNQPAMETPAEVPMKVLVPAFVTSELKTAFQIGFTIFIPFLIIDMVVASVLMGLGMMMVPPISVSLPFKLMLFVLADGWHMLLGSLARSFYQ
>NZ_CP021110.1|WP_086057679.1|2593682_2594012_+|flagellar-biosynthetic-protein-FliO
MADAAPFRVFIGLIVVIAAILLCGWIARRAGLAGRTHGGALRIVDSLNLGPRQRIVLVQVEDARLVVGIAANQMNLLHTLPPGSAAPEEPGLPASRAFAHKLGQALRRN
>NZ_CP021110.1|WP_086057689.1|2607627_2609307_-|flagellar-hook-associated-protein-FlgK
MSLYSLGLSGLNAAQAGLTTTGHNIDNAATDGYTRQRVLTSTAGATATSAGFYGRGVQVDTVQRQYDSFLYKQLVGSQSSASSYSTYLDQISQIDNRLGDETVGISPALAEFFASVNAVASGPADAAARADMIGTAQALVSQINSAYQDLQTQREGLNTQIASAVNQVNSYLSQINKLNQEIVIARAQGNGNAPNDLLDQRDQLLSELSQTVGIRYTTQGDMVSISLESGQALLSGTTVYSLQAVASSTDPSRTVVAYNLPSGPGGATTPVQLDDSKFKNGTLGGLMQFRSTALDTLQNRLGQMAVGLAMTFNAVHQQGVDRQGLPGGDFFSMISPAAISGAANAGTGGITADYTDASQITASDYSIKYVQSDPADPTTGQYVVTRLSDNTTNTYTPTGTPPTIAFDGLTLNLSGTPADGDTWTLQPTRNAARDLGMAITDPGKIAASSTTNPGTANGDNALALAKLQTARNLAGNTLSVTDLYAQIVNNVGQQTAAAKANDKAQTAVVNQRLANNSSVSGVNLNEEYVNLSQYQEQYQAAAKIIEVAGTMLDAILGLR
>NZ_CP021110.1|WP_086057690.1|2609414_2610551_-|flagellar-assembly-peptidoglycan-hydrolase-FlgJ
MALGPSSNAGASQSSIFDFGALASLHRDVTTQPNSAEKQAEVARQFEAVYIQMLLKQMRQATMQSGMFDSNESRMVRSMADEQLALQLANPGIGLAQSLLKQMRANQPGEAGQGRDGGTGAQAPQQPLDLAARTVARAAPDGEVAALLRLLNRNRASDRALAAAEGAPDHVVDFVSQMASAAKAAERQSGVPARLILGQAALESGWGQREIRYPDGRTSYNLFGIKAGDSWKGKVVNVMTTEYEDGVPRKVMQPFRAYNSYEESFADYARLISDNPRYEAVTQARDEYDAARRIQAAGYATDPRYADKLIGIMGQLAGTAGAGQGPDAGVAAGRPGPGATAFEGRSAPGWDGQDSAESARAEAVAALSAAEPIAGGVR
>NZ_CP021110.1|WP_086059437.1|2610563_2611631_-|flagellar-basal-body-P-ring-protein-FlgI
MAAGMGAHAERLKDLASIQGVRGNQLIGYGLVVGLDGTGDQVRQAPFTQQSVTNMLSQLGVTVPANSNMQLKNVAAVMVTMNLPAFARPGQTFDVVVSSMGNAKSLRGGTLLLTPLKGADGQVYALAQGNILVGGAGASAGGSSVQINQLNGGRISNGAVVERGVPTTFARDGNVFLELNELDFGTAQNVAAALNRHFGGGVSQVIDGRTIRVQAPVEPSAQAAFLSQLENLQVTRAPASAKVIINARTGSVVMNRTVMLEESAVAHGNLSVVVNQTNAVSQPNTPFGGGQTVVVPNTTIDVRQENGSLQHVRTSANLADVVRALNALGATPQDLLAILQAMQSAGALRAELEII
>NZ_CP021110.1|WP_086057691.1|2611911_2612607_-|flagellar-basal-body-L-ring-protein
MSPAMRAVRFLCSIVLAAGLGGCALIPPEPVVLGPTTAMPPPQPVPVPTPNGSIYQPTVYGNYPLFEDRRPRNVGDIVTVVLEERTAAAKNVATNTSRTSTTQNTVAASPGFMSSWFNSKLNTETEGANTNKGAGDSSANNTFTGTLTTTVVGVLPNGNLQVAGEKQIAINRGSEYIRFSGVVDPRSVSGLNTVSSTQVADARIEYRSKGVMDEVQTMGWLQRFFLIANPF
>NZ_CP021110.1|WP_086057692.1|2612606_2613392_-|flagellar-basal-body-rod-protein-FlgG
MLRSLWIAKTGLEGQQTSLDVISNNLANVNTNGFKRGRAVFQDLMYQTLRQPGAQVGDANQLPSGLQLGTGTRVAATERLHSEGNLTSTGDPMDIAIQGQGFLQVQLPDGTDAYTRDGSLQVDQNGQLTTAGGLVIQPPINVPNNALSLTIGKDGTVSVTQPAAPGTNVQIGQLQLANFINPNGLQAIGDNLYLETDASGAPNVGQPTVDGLGSILQNYVETSNVNVAEELVNMITTQRAYEMNSKAVETSDQMLARLTQL
>NZ_CP021110.1|WP_086057693.1|2613440_2614202_-|flagellar-basal-body-rod-protein-FlgF
MDRVIYTAMNGAARISEEQAVLSNNMANVNTPGFRAQIALYRSVPINDGTSLPTRVSTVASTPRNDFQAGVMQTTGRNLDVAITDNGWLAVQTPQGEAYTRAGDLQVGVNGLLQTAQGMPVLSNQNGPIDVPPDASLTIAVDGTITAIGAGDPPNTILNLGQLKLVSPPTESLVHGDDGVFRRVAANGQPAPPMPADPTLRVMPGVLEGSNANAASSMVGMIENARRFEMQMQVIRDAQANEEKANTILSTVS
>NZ_CP021110.1|WP_086057694.1|2614234_2615443_-|flagellar-hook-basal-body-complex-protein
MGFGQGLSGLDAASQNLDVIGNNIANANTVGFKSATATFADIYATSRVGLGVKVASIDQRFTVGNVTSTGGQYDIAIDGANGFFRLVDASGAVTYTRNGQFRIDKDLNLVNAAGQQLTGYGPAGVGTAPVPLSLPTANIAPEATNSSGFVANLNANANAIDPATTFDPTNAATYTDSQPMTVYDSLGNSHQLTQYFVKREANAAGESVYDVYYTLDGAAMTPASATLTFDKAGRMTSAPTVPVGFANPGGTGSPAADLAITLDYTGTTQFGSDFKADFTPNGNTSGEFTNISFGKDGSIVANYTNGKTQVVGVVALANFNNVNGLQPVGDNAWSETSESGQAVLGQPGTNGLATLQGQAVEASNVNLSTELVNMIVAQRTYQANTQTIKTQDQVLQSLLAIQ
>NZ_CP021110.1|WP_086057695.1|2615527_2616223_-|flagellar-basal-body-rod-modification-protein
MTTTSNVNNTTTTGGASSSSSSSASSAQSLQDQFLTLLVAQMNNQDPLNPMDNYQLTSQLAQISTVQGVQDLKTVVQAISGQVDLSQSMNAVSMIGKQVLIPGNSLKVDTDASGAKVMTPIGIDVQADAGDVVLKISDNTGRVVRTIDLGAQDAGIITPAWDGKDDSGNVMPDGAYTISVNATNADGSAVTAEALTYGQVGGISYTTQGVRLDLGLAGQVSMLDVRKVLGS
>NZ_CP021110.1|WP_086057696.1|2616263_2616680_-|flagellar-basal-body-rod-protein-FlgC
MGLLSIFDISGSALTAQSQRMNVAASNLANADSAVGPDGQPYRARQVVFQVNPGQGQMTGAEIGGVRVAGIVQDNAPMRRQYDPTNPLADAQGYVTMPNVDPVAETVNMISASRSYQANVEVLNTAKALMQKTLTIGQ
>NZ_CP021110.1|WP_086059438.1|2616699_2617107_-|flagellar-basal-body-rod-protein-FlgB
MIDRLSQDLGFFQQSLDLRAQRQEILSANIANADTPNYKARDFDFRSALESAMGAGMNLPPVNLALTSPRHIAAQGQSFPTVDLLYREPYQASLDGNTVDMDAERVQFADNTLHYQSTSTILSAKIKSMLTAISE

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Crispr_ID: NZ_CP021110_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_6

3072707-3072842

Orphan

Consensus_repeat	Method
AGGGGGCGACGCTGGCGGACCGGCGGAGCCGGATCCGCGGCGTCCTGGATAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_6

>merge|NZ_CP021110|6|3072707-3072842|CRISPRCasFinder
AGGGGGCGACGCTGGCGGACCGGCGGAGCCGGATCCGCGGCGTCCTGGATAGCCCCCCCGAAGCGCTGGCGCGCTTCCCCCTCAAGGGGGCGACGCTGGCGGACCGGCGGAGCCGGATCCGCGGCGTCCTGGATAG

>NZ_CP021110|6|6|3072707-3072842|CRISPRCasFinder
AGGGGGCGACGCTGGCGGACCGGCGGAGCCGGATCCGCGGCGTCCTGGATAG	CCCCCCCGAAGCGCTGGCGCGCTTCCCCCTCA
AGGGGGCGACGCTGGCGGACCGGCGGAGCCGGATCCGCGGCGTCCTGGATAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086058025.1\|3065444_3065624_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086058038.1\|3080389_3081256_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187613
NZ_CP021110.1\|WP_086058027.1\|3066316_3067759_-\|D-aminoacylase	unknown	unknown	gnl\|CDD\|238622
NZ_CP021110.1\|WP_086058035.1\|3076173_3077460_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP021110.1\|WP_086058036.1\|3077644_3078502_-\|3-deoxy-8-phosphooctulonate-synthase	unknown	unknown	gnl\|CDD\|235363
NZ_CP021110.1\|WP_086058037.1\|3078498_3080151_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NZ_CP021110.1\|WP_086058029.1\|3069980_3070853_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343
NZ_CP021110.1\|WP_086058028.1\|3068974_3069877_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
NZ_CP021110.1\|WP_086058024.1\|3064505_3065231_-\|5-oxoprolinase-subunit-PxpB	unknown	unknown	gnl\|CDD\|367142
NZ_CP021110.1\|WP_086058032.1\|3073491_3074412_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|224200
NZ_CP021110.1\|WP_086058021.1\|3061487_3061910_+\|CopD-family-protein	unknown	unknown	gnl\|CDD\|224892
NZ_CP021110.1\|WP_086059492.1\|3067822_3068809_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP021110.1\|WP_086058023.1\|3063439_3064498_-\|biotin-dependent-carboxyltransferase	unknown	unknown	gnl\|CDD\|214821
NZ_CP021110.1\|WP_157664490.1\|3074669_3075725_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377921
NZ_CP021110.1\|WP_086058039.1\|3081346_3083146_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|238518
NZ_CP021110.1\|WP_086058022.1\|3061928_3063470_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|236981
NZ_CP021110.1\|WP_086058034.1\|3075749_3076115_-\|cell-division-protein-FtsB	unknown	unknown	gnl\|CDD\|179156
NZ_CP021110.1\|WP_086058026.1\|3065807_3066320_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP021110.1\|WP_086058031.1\|3072933_3073455_+\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NZ_CP021110.1\|WP_086058040.1\|3083201_3084020_-\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|377424

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086058038.1\|3080389_3081256_+\|SDR-family-oxidoreductase	gnl\|CDD\|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.85282e-154
NZ_CP021110.1\|WP_086058027.1\|3066316_3067759_-\|D-aminoacylase	gnl\|CDD\|238622	cd01297, D-aminoacylase, D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.	7.6355e-130
NZ_CP021110.1\|WP_086058035.1\|3076173_3077460_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP021110.1\|WP_086058036.1\|3077644_3078502_-\|3-deoxy-8-phosphooctulonate-synthase	gnl\|CDD\|235363	PRK05198, PRK05198, 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional.	0
NZ_CP021110.1\|WP_086058037.1\|3078498_3080151_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NZ_CP021110.1\|WP_086058029.1\|3069980_3070853_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	6.61573e-82
NZ_CP021110.1\|WP_086058028.1\|3068974_3069877_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	4.19862e-54
NZ_CP021110.1\|WP_086058024.1\|3064505_3065231_-\|5-oxoprolinase-subunit-PxpB	gnl\|CDD\|367142	pfam02682, CT_C_D, Carboxyltransferase domain, subdomain C and D. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the C and D subdomains of the CT domain. This domain covers the whole length of kipI (kinase A inhibitor) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	2.20011e-78
NZ_CP021110.1\|WP_086058032.1\|3073491_3074412_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|224200	COG1281, COG1281, Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones].	2.45933e-101
NZ_CP021110.1\|WP_086058021.1\|3061487_3061910_+\|CopD-family-protein	gnl\|CDD\|224892	COG1981, COG1981, Predicted membrane protein [Function unknown].	4.42211e-50
NZ_CP021110.1\|WP_086059492.1\|3067822_3068809_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.43063e-138
NZ_CP021110.1\|WP_086058023.1\|3063439_3064498_-\|biotin-dependent-carboxyltransferase	gnl\|CDD\|214821	smart00797, AHS2, Allophanate hydrolase subunit 2. This domain represents subunit 2 of allophanate hydrolase (AHS2).	1.25012e-131
NZ_CP021110.1\|WP_157664490.1\|3074669_3075725_+\|hypothetical-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	6.08511e-05
NZ_CP021110.1\|WP_086058039.1\|3081346_3083146_-\|aminopeptidase-P-family-protein	gnl\|CDD\|238518	cd01085, APP, X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.	3.38494e-118
NZ_CP021110.1\|WP_086058022.1\|3061928_3063470_+\|RNA-methyltransferase	gnl\|CDD\|236981	PRK11783, rlmL, bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL.	4.29974e-130
NZ_CP021110.1\|WP_086058034.1\|3075749_3076115_-\|cell-division-protein-FtsB	gnl\|CDD\|179156	PRK00888, ftsB, cell division protein FtsB; Reviewed.	1.29193e-54
NZ_CP021110.1\|WP_086058026.1\|3065807_3066320_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	8.26891e-12
NZ_CP021110.1\|WP_086058031.1\|3072933_3073455_+\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	3.85202e-69
NZ_CP021110.1\|WP_086058040.1\|3083201_3084020_-\|M55-family-metallopeptidase	gnl\|CDD\|377424	pfam04951, Peptidase_M55, D-aminopeptidase. Bacillus subtilis DppA is a binuclear zinc-dependent, D-specific aminopeptidase. The structure reveals that DppA is a new example of a 'self-compartmentalising protease', a family of proteolytic complexes. Proteasomes are the most extensively studied representatives of this family. The DppA enzyme is composed of identical 30 kDa subunits organized in a decamer with 52 point-group symmetry. A 20 A wide channel runs through the complex, giving access to a central chamber holding the active sites. The structure shows DppA to be a prototype of a new family of metalloaminopeptidases characterized by the SXDXEG key sequence. The only known substrates are D-ala-D-ala and D-ala-gly-gly.	2.5866e-133

>NZ_CP021110.1|WP_086058029.1|3069980_3070853_+|UDP-2,3-diacylglucosamine-diphosphatase
MKARTEGYVNEIRPTHWRTVWISDLHLGTTGCKAEFLLDFLDHNEAETLYLIGDIVDGWQLRKHWHWPRAHNDVIQRILRKAREGTRVVFVPGNHDEFAREFVGYAFGDIEIVDEDVHHTADGRRLLVLHGDQFDGVIQHSKWLAHLGDSLYQFALWLNHYFNRMRHRMGLHYWSLSQYLKHKVKNAVAFITDFEHALAGEARRRGLDGVVCGHIHKAEMRDIDGVLYCNDGDWVESLSALAEDHAGRLQLIDWAAVLAERAADAPPARAPRPVSLPALPSALRRQGKHS
>NZ_CP021110.1|WP_086058028.1|3068974_3069877_+|LysR-family-transcriptional-regulator
MKHPNGKSIPSVTNLTAFEAVAAAGTITAAATALSLTQSAVSKQIAELQSFLGIRLFERSEGRLRPTPAGALYLQRVRPALAELEEATLEAQASAASRGVGGHLNLSVPATFGAMWLLPRLSSFALEHPQIVVNLSTKIGPVPLPSPTLDAAIMYVAGARDEALSYQAAWPLRVHPVCSPRLGGARDGAATLLKREPLLHQTSTPDAWLRYCRERWAGKITPRAGPRYALLSMGLQAASAGLGIALLPDYVIADAVSRKDLRVLDDSPFQLGGAYMFVCPKQNRQSPAIAAFSAWLARQA
>NZ_CP021110.1|WP_086059492.1|3067822_3068809_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MRRRATLRTLVSAVIAMTALASPNSHAKDSWPNQPIRLIVPSAAGGSPDILCRYLGAELSARLGQPVVVENRPGAGGNIGMQAVARAEPNGYTIGYGNIATLAINRSLFSSLPYDPDRELAPIVAAVTTANLLVVNKDLPVKSVSELVAYAKSRPGSITMGSAGNGTTSHLGGELFKVTEQLNVVHVPYRGSPQAIQDLIGGNVQFMFDNLPSILPSVNAGLVRALAVTAPARSPLAPDVPTMQEAGVKDYELQAWGGFVAPAGTPQPIVDRLNREFNAMLSDENVRRKLSELAFEPIGGTPQAFRDLMNRETGKWGKLVRQANARVD
>NZ_CP021110.1|WP_086058027.1|3066316_3067759_-|D-aminoacylase
MPDSNRYDVLIRGGTVVDGTGAPRRQEDLALRDGRIAAMGDLRDADARHTIDAQGLIVAPGFIDSHAHDDYAVIETPDMAFKVLQGVTTVVNGNCGLSLAPLVTRERPPAPLDLLGDAYHYRDFATYRAAVDAADPAVNVAAMIGHSTLRVRHMADLQRAATRAEIAAMRADLADGLRAGAIGMSTGTFYPPAAHAPAEEIIEIGAPLRELGGVYATHLRDEGDEILEAIEESLRIGAALQAPIIFSHHKLVGTRNHGRSEETLAVLAQAAARQPLCADCYPYAASSTMLRPERVEICDRIMVAWSAPHPEASGRDLRELAREWGCSAREAAERLLPAGAVYFIMDEGDVRRILSWPETMVGSDGLPKDIRPHPRLWGTFPRVLGHYARDVGLFSLEAAVHKMTGLTAAKFGLSGRGVLRAGNIADIVVFDAARIADTATFDAPEGAPLGIEYVLLGGRMTVTHGTPTGARGGRYIGRSA
>NZ_CP021110.1|WP_086058026.1|3065807_3066320_+|RDD-family-protein
MTDLSATPAPPRLRRFACMMYEAVLLFGVVFLAGYLFDTLTQSRNALMLRHARQTWLFLAVGAYFVLCWRRSGQTLPMKTWHIRLVDRNGGAPGLPRLVLRYVLSWILPLAAAGLIWGLAFLSHWPATLMFIVAAPFAIFAGSWLDPQGQFLHDRWAGTRLISVARTVPR
>NZ_CP021110.1|WP_086058025.1|3065444_3065624_+|hypothetical-protein
MNEREPLRLTDELERELMRQAIEEQFRPRPFRALAKMITKLARSLRASASRPNGEAVRA
>NZ_CP021110.1|WP_086058024.1|3064505_3065231_-|5-oxoprolinase-subunit-PxpB
MDTPAPSLPAPWRIAPVGDRCLLVRLADKVDAQANRRVLALAANLLSDPLEGVIDVVPAFTTVALHYVPTPAPDGSSPYERLAAQLEARLRRGIPAIDIGGRVVEVPACYGGEYGPDLEQVAARCGLSAQEVIRRHVESPLVVYTFFFAPGCPFAGGLDPGLSVPRRPTPRTEVPPGSVAIANGLSMIYPLAMPGGWNLIARTPWRLFDLRQDPPVRLQLGDRLRFVPVSPAEFARMEQAG
>NZ_CP021110.1|WP_086058023.1|3063439_3064498_-|biotin-dependent-carboxyltransferase
MQRKREPVRHACVVLKPGAWSLLQDLGRYGHQRYGVPVNGVMDEWAHRVANILVGNAEGAPTLECTLTGPALRFTGERLIALAGADMGATVDGLPAPLHQPLLVRAGATLQFGERRRGARAYLAVRGGFDAPPVMGSASTFVRGGYGGFQGRALAAGDRLPLRDADFGYPNARRLLVQCGLPFVSAAQLELPEREGGLDVLRAMPGPQWEAFTAEARTSFYGGDFRIAAQSDRMGYRLEGPRLALAQPLEMISEAVSFGTVQVPPDGNPIVLMADRQSAGGYPKIAYVASVDLPLLAQAMPGDTVRFAPVTLAQAQALYLAREAAFAALRDRVAAAMAGGALGQEAGLRLSR
>NZ_CP021110.1|WP_086058022.1|3061928_3063470_+|RNA-methyltransferase
MSADDSERPRKTLTLARRPDDAARRQEADKRKRAGGRARHVAQQEKQRDKAARLDTAPAPPAAGPSDPPARDKRDERRSSRSGPARPHRSDTASAPSPANNEDANARFAQRPDRAPRRARGSASRDGERFQVFAPCPQGLEEALTVELRALGYDDARAGRAGAHFSADWAGVQRANLYSRLATRILVQVAQAPVQTEDDLLDLAYATPWERWFGAERTLRVDTSAIKSPMRSLQYCNLRVKDGICDRLMDREGARPDIDTVRPDARVHAFLTVDTATLYLDTSGESLFKRGWRLDKGEAPLRENLAAGMLALADWDPGAPLLDPFCGSGTILIEAAWIALGVPPGIARPFSFERLRDHDARRWQDIKEDARAHIAPRLETPLFGYDIDPQAIEHARRNAERAWLTEDAIRFEVGDARTLAAPADTGWIVTNPPYGERLQSGHDESLWRDWAACLKRNFAGWQVHAISSDMTLPQQMRLKPLRRIPLHNGPLDCRLFGFELVSASYRDKRSPAS
>NZ_CP021110.1|WP_086058021.1|3061487_3061910_+|CopD-family-protein
MLWIKTLHIVFIASWFAGLFYLPRIYVNLAQHDEAGARTVLLGMARRLFRFTTLLAVVAVIFGLWLYIGYGIGMGPGNGWMHAKLFFVLLIIGYHHACGVMLRKFEQGRNTRSHTFYRWFNEIPVLLLFIVVALVVVKPF
>NZ_CP021110.1|WP_086058031.1|3072933_3073455_+|gamma-carbonic-anhydrase-family-protein
MAIYELDGVAPRIDASAYIADSADIIGDVTLEAEVSIWPQVTIRGDNAPIMIRARSNIQESSVLHVDHGHGLIVESDVTVGHQAMLHGCTIREGALVGIQAIVLNDAVVGRNCLIGAGAIIPEGRVIPDNSLVIGIGKVVRELSAEEIEQMHKNTHGYVMRGQQYKRVLKRIG
>NZ_CP021110.1|WP_086058032.1|3073491_3074412_+|Hsp33-family-molecular-chaperone-HslO
MTDLLKKYLFEDRTVRVQAVRLHETWREAQVNHDYPPAVKRLLGELIAAATLLAANLKFEGSLVMQVQGDGPIALLVVECRADLSLRATVKLRQDRVVPDTGTMQTLMNPGGNGRFIVVLDPQRKAPGQQPYQGIVPIVGETVADALSHYMQQSEQLDTRLWLAADDSHVAGLLLQRLPDQGGAAVHPGDPQESWNRAVHLTETLQADELRETDIDTLIHRLYWEETLIAFEPAQVRWHCPCNRTKVSDMLRMLGREEIEEILAERGKVEVACDFCGKPYAFDAVDCAGLFSGPQTLPEQDPPTVH
>NZ_CP021110.1|WP_157664490.1|3074669_3075725_+|hypothetical-protein
MRCRRIPCRQRGAALAEFALAAVPLLFLGFLSVEAARWHATRQMLYVALLDAARAGATSHARPDVIERRFEHALLPLFHPPGAHGGAAARMRAAFADITRQAGVLPWRIDVLSPSPAAFADFADSGLRVPGASALRAIRNDYQAEQHARRRGQGWADGRGPRSRQTIFDANTLRLRLHYVHPPLMPGMRALLRAIGTQRQTSGQGPEAHRNAAAARAGMLVVAMELSLPMQSHPVQWRATATARHQPHPKSGTAQPNGRIRDGARLPHWADEAGDAAEPFWIPGHAANRPLRETAAQSGRPSLAKRNGAIATLAPREPTLADAQAADSSGMTDQDAEACGVILCCQDKSTG
>NZ_CP021110.1|WP_086058034.1|3075749_3076115_-|cell-division-protein-FtsB
MRLLFLVLLALVCLIQYPLWFGKGGWFKVWDLQKQVAAQRAVNEGMRARNAALDAEVRDLQTGTGAIEERARSELGMMKDGEVFVQIVPKGENPPPNAQSAGAVRNATAVSTPGPAGAPRR
>NZ_CP021110.1|WP_086058035.1|3076173_3077460_-|phosphopyruvate-hydratase
MSAIVDIIGREILDSRGNPTVECDVLLESGAMGRAAVPSGASTGTREAIELRDGDKGRYLGKGVLRAVENLNTEISEALMGLDAQEQTFVDRTLIELDGTESKERLGANAILAASMAVARAAADESGLSLYRYFGGSGPMSMPVPMMNVINGGAHANNTLDLQEFMILPVGASSFREALRWGAEVFHALKKLINAQGMSTAVGDEGGFAPNVANHEAAIQLILKAIGEAGYEPGTQIALGLDCASSEFFRDGKYTLEGEGGISLSSQEFANLLATWCDKYPIISIEDGMAENDWEGWKLLTDQLGKKVQLVGDDLFVTNTRILKEGISKGIANSILIKINQIGTLTETFAAIEMAKRAGYTAVVSHRSGETEDSTIADIAVATNAMQIKTGSLSRSDRMAKYNQLLRIEEELAEVASYPGLEAFYNLR
>NZ_CP021110.1|WP_086058036.1|3077644_3078502_-|3-deoxy-8-phosphooctulonate-synthase
MMKLCGFEAGLRQPFFLIAGPCVIESRELAFETAGKLKEITGKLGIPFIYKSSFDKANRSSGKSYRGPGMQEGLKILADVRAQLGVPVLTDVHDTPQVDEVAAVVDVLQTPAFLCRQTDFIRACAATLKPVNIKKGQFLAPHDMKQVALKARDAAIEAGGDGNTIMVCERGASFGYNNLVSDMRSLAIMRETDCPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAVAVGVAGLFMETHPNPACAMSDGPNAVPLDRMAELLESLLALDRVVKAGSFIEENFQ
>NZ_CP021110.1|WP_086058037.1|3078498_3080151_-|CTP-synthase
MTKYVFVTGGVVSSLGKGIAAASLGAILESRGLQVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRKVNNFTTGQIYESVLRKERRGDYLGKTVQVIPHITNEIQDFIARGAEAGWDGNTDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNNAVFIHLTLVPFIASAGELKTKPTQHSVQKLREIGIYPHALLCRADRPIPDDERAKISLFSNVPLDAVISVWDADSIYKIPAMLHKQGLDNLVCDALGLTPPPADLSMWDDLVEALEHPQHEVTIGMVGKYVDLTESYKSLTEALVHAGIHTRSRVNIEYIDSEDLEANGTDGLRHLDAILVPGGFGKRGTEGKIAAIRYARENGIPYLGICLGMQLAVIEFARHVAGLGGANSTEFDPAAPHPVVALITEWMDREGRVEKRDANSDLGGTMRKGAQRCPVKPGTRAAQIYGPEVNERHRHRYEVNNVYVPRLEDAGMVISARTPTENLPEMMELPSHPWFVGVQFHPEFTSTPRDGHPLFSSYIQAAIERQARRGKES
>NZ_CP021110.1|WP_086058038.1|3080389_3081256_+|SDR-family-oxidoreductase
MTDSQRPTPPFTDQQQDQTPGQTAPMSPQPDHGEQSYRGSGRLSGKAAIITGGDSGIGRAVAIAYAREGADVLIAYLNEHDDARETARWVEEAGRKAVLLPGDITDPAHCEQIVERAVQEFGRLDVLVNNAAYQMTYPSLEDISDEEWNKTFDTNIGAMFRITRAAVRHMKPGASIINTTSINADHPNPGLIAYAATKGAIQNFTGGLAQLLAEKGIRANCVAPGPIWTPLIPSTMPPEKVEQFGKQVPMKRPGQPAELAAPYVMLASDEASYISGATIAVTGGSPII
>NZ_CP021110.1|WP_086058039.1|3081346_3083146_-|aminopeptidase-P-family-protein
MSNTDARIAALRQAMAARGMSAYIVPSADPHLSEYLPGRWQGRQWLSGFTGSVGTLVVTADFAGLWVDSRYWVQAQAQLAGTCIALMKLGEPGVPSHVDWLGANVPAGGRVGVDGQVLSLAGHRALSAALEPAKAALDTAHDLLADIWPDRPGLPAAPVREHRAPYACVPRADKLAGVREAMREKGATAHLISTLDDIAWLFNLRGADVDYNPVFVAHALVLADRAELFVAEGKIDAALRDTLAADGVVVQPYARCATVLSALPADSVVLLDPQRVTVGVQGALPEKARRVEAINPSTLAKSRKRDDELAHVRAVMEQDGAALCEFFAWFEAALGRERITELTIDEKLSAARARRPGFVSLSFGTIAAFNANGAMPHYRATAASHAVIEGDGLLLIDSGGQYEGGTTDITRVVAVGTPSAEQKRDFTLVLKGMIALSRARFPRGIPAPMLDAIARAPIWEGGAEYGHGTGHGVGYFMNVHEGPQVIAYRAQATPHTAMEPGMITSNEPGIYRPGRWGVRIENLVCNRPWQTTELGEFLAFETLTLCPIDTACIQPDLLRPDEIAWLDAYHAEVRERLLPHVQGDARNWLLARTEPLAAR
>NZ_CP021110.1|WP_086058040.1|3083201_3084020_-|M55-family-metallopeptidase
MRILVSTDIEGVAGVFHSQQVTAGNPEYERARAWMTGEANAAVAGAFDGGADDVLVNDSHGGYRNLLPDGIDERARLVMGKPRYLGMMGGLEESCDAVFLIGYHSRSQGRGVLAHTINSFAFAKVCINGMELGEAGIYGALAGELGVPVALASGDDVFIGETRELFPGARWVQTKVATGRSSGISLSPAASRAAIREAAREAVAHIGQLKPWRIEPPIECVLQTQGPALAELFCTWPALERVDGVTVRFTAGSMRDAVRVLNSLAAMSFMLR

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Crispr_ID: NZ_CP021110_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_7

3956393-3956482

Orphan

Consensus_repeat	Method
AAGGGGGCGACGCTGGCGGACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_7

>merge|NZ_CP021110|7|3956393-3956482|CRISPRCasFinder
AAGGGGGCGACGCTGGCGGACCGGAGGGGGAAGCCCACCCCCGAAGCGCTTACGCGCTTCCCCCTTAAGGGGGCGACGCTGGCGGACCGG

>NZ_CP021110|7|7|3956393-3956482|CRISPRCasFinder
AAGGGGGCGACGCTGGCGGACCGG	AGGGGGAAGCCCACCCCCGAAGCGCTTACGCGCTTCCCCCTT
AAGGGGGCGACGCTGGCGGACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086058716.1\|3953044_3953959_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274127
NZ_CP021110.1\|WP_086058712.1\|3949075_3949972_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176113
NZ_CP021110.1\|WP_086058718.1\|3956736_3957435_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP021110.1\|WP_086059597.1\|3960904_3961849_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP021110.1\|WP_086058721.1\|3961865_3963206_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_CP021110.1\|WP_086058709.1\|3945641_3945830_-\|DUF3460-family-protein	unknown	unknown	gnl\|CDD\|378768
NZ_CP021110.1\|WP_086058713.1\|3950115_3951309_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP021110.1\|WP_086059595.1\|3958794_3959772_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP021110.1\|WP_086058711.1\|3947382_3948942_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_CP021110.1\|WP_086058724.1\|3966197_3966938_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP021110.1\|WP_086059596.1\|3959818_3960457_+\|maleylacetoacetate-isomerase	unknown	unknown	gnl\|CDD\|273527
NZ_CP021110.1\|WP_086058715.1\|3952350_3952974_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP021110.1\|WP_086055842.1\|3955417_3956374_+\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP021110.1\|WP_086058714.1\|3951360_3952308_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP021110.1\|WP_086058717.1\|3954147_3955200_+\|gentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|131325
NZ_CP021110.1\|WP_086058723.1\|3964897_3965902_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP021110.1\|WP_086058722.1\|3963628_3964816_+\|3-hydroxybenzoate-6-monooxygenase	unknown	unknown	gnl\|CDD\|181262
NZ_CP021110.1\|WP_086058710.1\|3945938_3947393_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|182502
NZ_CP021110.1\|WP_086058720.1\|3960488_3960863_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|214841
NZ_CP021110.1\|WP_086058719.1\|3957474_3958737_+\|flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236046

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086058716.1\|3953044_3953959_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|274127	TIGR02424, TF_pcaQ, pca operon transcription factor PcaQ. Members of this family are LysR-family transcription factors associated with operons for catabolism of protocatechuate. Members occur only in Proteobacteria. [Energy metabolism, Other, Regulatory functions, DNA interactions].	8.2711e-45
NZ_CP021110.1\|WP_086058712.1\|3949075_3949972_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176113	cd08421, PBP2_LTTR_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.99379e-87
NZ_CP021110.1\|WP_086058718.1\|3956736_3957435_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	5.8623e-90
NZ_CP021110.1\|WP_086059597.1\|3960904_3961849_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	8.20541e-119
NZ_CP021110.1\|WP_086058721.1\|3961865_3963206_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	5.88598e-136
NZ_CP021110.1\|WP_086058709.1\|3945641_3945830_-\|DUF3460-family-protein	gnl\|CDD\|378768	pfam11943, DUF3460, Protein of unknown function (DUF3460). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 70 amino acids in length. This protein has a conserved WDK sequence motif.	1.1761e-27
NZ_CP021110.1\|WP_086058713.1\|3950115_3951309_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	8.04822e-146
NZ_CP021110.1\|WP_086059595.1\|3958794_3959772_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	4.09814e-137
NZ_CP021110.1\|WP_086058711.1\|3947382_3948942_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP021110.1\|WP_086058724.1\|3966197_3966938_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	7.53405e-164
NZ_CP021110.1\|WP_086059596.1\|3959818_3960457_+\|maleylacetoacetate-isomerase	gnl\|CDD\|273527	TIGR01262, Maleylacetoacetate_isomerase, maleylacetoacetate isomerase. Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. [Energy metabolism, Amino acids and amines].	4.76172e-105
NZ_CP021110.1\|WP_086058715.1\|3952350_3952974_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.40987e-38
NZ_CP021110.1\|WP_086055842.1\|3955417_3956374_+\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.48556e-21
NZ_CP021110.1\|WP_086058714.1\|3951360_3952308_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	4.23944e-130
NZ_CP021110.1\|WP_086058717.1\|3954147_3955200_+\|gentisate-1,2-dioxygenase	gnl\|CDD\|131325	TIGR02272, gentisate_12-dioxygenase, gentisate 1,2-dioxygenase. This family consists of gentisate 1,2-dioxygenases. This ring-opening enzyme acts in salicylate degradation that goes via gentisate rather than via catechol. It converts gentisate to maleylpyruvate. Some putative gentisate 1,2-dioxygenases are excluded by a relatively high trusted cutoff score because they are too closely related to known examples of 1-hydroxy-2-naphthoate dioxygenase. Therefore some homologs may be bona fide gentisate 1,2-dioxygenases even if they score below the given cutoffs.	0
NZ_CP021110.1\|WP_086058723.1\|3964897_3965902_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	6.63226e-142
NZ_CP021110.1\|WP_086058722.1\|3963628_3964816_+\|3-hydroxybenzoate-6-monooxygenase	gnl\|CDD\|181262	PRK08163, PRK08163, 3-hydroxybenzoate 6-monooxygenase.	0
NZ_CP021110.1\|WP_086058710.1\|3945938_3947393_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|182502	PRK10504, PRK10504, putative transporter; Provisional.	1.09214e-97
NZ_CP021110.1\|WP_086058720.1\|3960488_3960863_+\|chorismate-mutase	gnl\|CDD\|214841	smart00830, CM_2, Chorismate mutase type II. Chorismate mutase, catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine..	8.6992e-15
NZ_CP021110.1\|WP_086058719.1\|3957474_3958737_+\|flavin-dependent-oxidoreductase	gnl\|CDD\|236046	PRK07538, PRK07538, hypothetical protein; Provisional.	0

>NZ_CP021110.1|WP_086055842.1|3955417_3956374_+|transposase
MSEATYVGIDVSSEVLEIAVSTQPSTWQASNDSGGIEQLAGQLQALRPALVVLEATGGYEFEAACVLQAQGLAVAVVNARMARDFARAMGALGKTDALDARMLATFARVLDQHPDRARFVKPLADAQLQRLQALVLRRRQIVQTMTSERHRLRISHEAARPSIERHLAFLRQELDDSDGHIAEHVQQHQAELARVLSSVPGIGAASVALLLAELPELGRLDRRRIAALVGVAPVNRDSGKMRGQRSIWGGRASVRCALYMASLSAVRYNPVLRAYYQRLLGTGKKKKVALVATMRKLLTILNAMVRHNKQWEPALDCP
>NZ_CP021110.1|WP_086058717.1|3954147_3955200_+|gentisate-1,2-dioxygenase
MAEGTSTRADRAAYYERIARKNLAPLWESLHNLVPRTPQPRCVPAMWRYNDVRADVMEAGSLITAEEAVRRVLILENPGLPGQASITQTLYAGLQLILPGEIAPSHRHTQSALRFIMEGKGAYTAVNGERTTMHPGDFIITPSWTYHDHGNLEASEGGEPVVWLDGLDIPLLRMLDAGFAENYPASTQPVTRPEGDSYARYGYNMAPVRYQPANGNSPIFNYPYERSREALDRLYRFGELDAWDGVKLRYINPATGGSPMPTMATFMQFLPAGFQGKTTRSTDSTVYSVVEGRGTARVGDQEFHFGPRDVFVAPSWQPVQLAAAEDAILFSFSDRPVQMALGLLREERLE
>NZ_CP021110.1|WP_086058716.1|3953044_3953959_-|LysR-family-transcriptional-regulator
MDWTYRLRLRNLKMLLSLAQTRNISHSAAMLNTTQPGLSKWLKDLEDDIGLPLFERHARGLRPTPYGEALIAHARRIDAQLERASGDMAALRQGGGGRVVIGASGASASDTVPLAVMRLLERMPQARIKLVESTMDHLLAQLAQGELDIVVGRSAPEHHDPAILSESLYLEPVHMVARPRHPVFSLPSVTWEDLMDYRWIVWPKGTPIRNALDTALAAAGKALPADHVESNSVTINLTLISQSDLIGVASHRAALRFAQMNAMRILPVRLSGFGAVTMYWRQETFQPAAVEAALECLRGVVAEP
>NZ_CP021110.1|WP_086058715.1|3952350_3952974_-|LysE-family-translocator
MPIEQWLAFVAASAVLLIIPGPTIVSVISYSLAHGRRARWPLVAAVALGDSTALAVSLLGLGALLAASAFWFTVVKWIGGCYLLYLGLRLLRAGASAQPAQPAAQAVSRWKLFANTWLVTALNPKGIVFFVAFLPQFIRPDGDAARQLWVLAVTFVALAAVNATLYACCAGAASRWLASPAARRGFHLAGGTLLSGAGLWALLARRP
>NZ_CP021110.1|WP_086058714.1|3951360_3952308_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MHPGLHHNKEGDTFMLKPRITSPLRRLLALAGLCAAAAARLIAQPLSRALNQTVVVENKPGASGSIAAQAVTRAAPDGYTLLLQYSGYQVITPLITPNLGWDPVKDFTPIANVLSAPQVVVIRPSLPIKSLKELVDYAKAHPGELNYASSGNGSLQQVATELLNQMAGTRIVHIPYKGTGPAMNDLLGGAVDMTITTPPPLLGQIAAGKLRALAVTGKSRLPSLPDVPTAAEAGYPDLIVSSWFAMYAPANTPKEVVDKLSGEIEKIMRTEEFRKKAAEQGAEAEFMGPEALGKYTRDELVRWKTVVDKAQIKAN
>NZ_CP021110.1|WP_086058713.1|3950115_3951309_+|CoA-transferase
MTRQILAGIRVIELGQLIAGPFAAKTLADFGAQVIKIEPPGVGDPLRKWRLLHEGTSVWWEAQSRNKQSVCVDLRQTEGQEIVRMLAAEADVLIENFRPGTMEKWGLSWETLHALNPRLIMLRISGYGQTGPKAGEPGFAAIGEAMAGLRYLNGEPGRAPVRAGLSLGDTIAGLHGALGVLLALYERDARGGKGQVIDAALYESVFNLTESLLPEYSVFKAVREPAGAALPGIAPSNAYRCQDGYVLIAGNGDGIYTRLMARIGREDLAHDPALAHNDGRVARVQEIDGAIGAWTQNRTIDQVLEAMREAGVPAGRIYSVADIAQDPHYRARNAIVSVRSASGVAVEMPAVFPLLSEHPGAVRERAPTLGEHTDAVLREAGLDEARIAALREARVIE
>NZ_CP021110.1|WP_086058712.1|3949075_3949972_+|LysR-family-transcriptional-regulator
MNLARIDLVTLSLFVSVARLGSISAAARQARLAVGAASKRISDLEAALGSPLLFRKAAGVELTDAGQACLAHATRILQEVDQMAGTLSDYAKGVRGQVRIAANTSSITQFLPDDLSRFMTEHPAVRIDLEEQNSTDIVSAVVENRADIGIFGERTPDGGLQTFPYKRDELMLVVPDSHPLSARAGVAFAETLEYDYVGLPANTSLASMLAQECARLDMPMKLRIQVRSFDAICRMVLATRGVGVLPRIAAEPHARSMQLRLIPLTDDWTRRWLLLGVRDVETLPLAARMLLAQLRAAQ
>NZ_CP021110.1|WP_086058711.1|3947382_3948942_+|glycerol-kinase-GlpK
MKNDYILALDQGTTSSRAIVFDRAGRARGVGQREFRQYYPHPGWVEHDAAEIWRSQLEVAREALSNAGVTAADIAAIGITNQRETTLIWDRATGRPLSHAIVWQDRRTAEACDRMRGDGCADFLQRRTGLVLDAYFAGTKLAWLLDNVPGARARAERGEVAFGTIDTWLIWQLTGGKVHSTDCTNASRTLLFDIHTQDWSDELLECLNIPRAVLPSIAPSSAIVAETLPQWFGGAIPIAGVAGDQQAATFGQACFKPGMAKNTYGTGCFMLMNVGDKPVTSNHKLLSTVGWGLPRPQDDNADAQVFREGTPAWTPTFMLEGGVFVAGAAVQWLRDGLGIIPRSEDIEALAGSVQDTDDVFLVPAFAGLGAPHWDPYARGTLVGLTRGTTRAHVARATLESIALQSAELLTAMKADCGIELSELRVDGGAARNDLLMQMQADLLGVPVVRPRVSESTARGAAGLAGLAVGFWEDMDAFAAQWQAERRFEPTWSADRREARLHRWAQAVELSKGWADGAAR
>NZ_CP021110.1|WP_086058710.1|3945938_3947393_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MPTKTLASAPPLADPAALRAARMIPFIVGCALFMQMLDATVVATALPAMAASLHSTPVKLNVAITSYLLAAAVFVPVSGWAADRFGARRVFIAAIVLFTASSVACALSQNVAQLVLSRIAQGMAGAMMVPVGRIILLRTVPKEDLLKAMSFLSIPALLGPVIGPPLGGFLVTYASWHWIFLINVPMGVLGVALILRYIREVREQGVPGLDWLGFVLSGVCLAALVSGFEAVGRDVMSDAQLLGLIAVGLLCGFWYVRHSRRVAHPIIDLSLMRVPTFAISTLAGNLCRFSVGGTPFLLAMLLQVGFGLTPFAAGMITFASAAGALLMKFVATPIVRRFGFRRVLTVNALLTGAFICACALFEPTTPSWLIILVLLIGGFFRSLQFTGVNTLTYADITPDKMSRASSFAAMAQQLGISLGVGVAAVTLNVSMALRGADRVSIGDIVAGFLVIGLCCAASFFSFRRLDPAAGNQLNGRKVQTSDEE
>NZ_CP021110.1|WP_086058709.1|3945641_3945830_-|DUF3460-family-protein
MAKNYESEITLFLKEYKKKHPDVEKRQREGRGLLWDKPQDPELLEGFRAARVPQKPYVYQPD
>NZ_CP021110.1|WP_086058718.1|3956736_3957435_+|fumarylacetoacetate-hydrolase-family-protein
MSYVFAPPTIVAVPVAGSADSFPVRRVYCVGRNYAAHAREMGFDPDREPPFFFCKPADAVMPVAEGETLELPYPAETANYHYEIELVAAIGKAGANISVDSALDHVYGYAVGLDMTRRDLQMKMREAGRPWELGKAFDDSAPIGPIHTVAAKGHHDQAGIWLKVNGQDKQRSDTSKLIWSVAETIAYLSRYFRLAPGDLIYTGTPEGVGPVVKGDLMEGGVDGLGTLRARVI
>NZ_CP021110.1|WP_086058719.1|3957474_3958737_+|flavin-dependent-oxidoreductase
MKDTDVIIVGAGVGGLVLALSLHQAGIACRVYEAVPEIKPLGVGINLLPHAARELDELGLLPALDRVGVHTRESIFFTRHGQLIYSEPAGKAAGYAWPQYSIHRGDLQMTLLAAVRERLGEDNVRVDHRAVRVEQDDDAVTVHMTDSAGNPRPPVRGAIVVGCDGIHSALRKQLYPNEGAPRYSGVNMWRGVTRCKPFLSGASMVRAGWLSIGKMVIYPIRDNVDAEGNQLVNWVAEIESPEPAVRDWTRQGRLEDFFPAFADWRFDWLDVAALIRNADSVLEYPMVDQDPLPTWTQGRMTLLGDAAHPMVPRGSNGAGQAIIDARYLAGQLKRQGLTPAALQDYDRVRVAATTRVVLTNRSNPPDAILREAYERSHDQPFDRIEDIISRDELQAISDRYKQIAGFDPETLSSRPSFLSV
>NZ_CP021110.1|WP_086059595.1|3958794_3959772_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MIATCRALAAWSVGLVMALTAAASQAAWPERPVTLVVPFTPGTGIDLIARQLSAALPKTLGQPVVVENLAGASGNIGTEKVARAAPDGYTFLVTVNTFVMNQPLYREKLHYDPVKDFAPVSLTSWGTLLLVTHPSNPVNTVRQMEDAARKQPGKLTYGTPGVGTPHHLAMALLLDQTKVSLLHVPYKGTAGAVTDMLAGRLDYMFLPVHVALPQIKAGKLKAIATGSPKRMPQLPDVPTLTESGLQGADVDMWYGVLAPRGTPKEVVDSLNRQIAEALKAPSVATAFEAQGMVPATSTPEEFGALIAKDAKRWSDVVDRAGIKAD
>NZ_CP021110.1|WP_086059596.1|3959818_3960457_+|maleylacetoacetate-isomerase
MQLYSFFNSSTSYRVRIAMALKGLRYDYLPVNIRVLEHRKDDYVDRNPSASVPLLVDGEMNLGQSLAIIDYLDAAHPKPRLLPQDPALRARVLEVSSVIACDMHPVNNLRILRYLQDVLGVSAEQKNAWYAHWIREGMTAVETLLQRHGSGAYCFGDAPTLADCCLVPQIANAERMGCDMSAYPRAMAVYAHCQAQPAFQQAAPRNQPDFIA
>NZ_CP021110.1|WP_086058720.1|3960488_3960863_+|chorismate-mutase
MQEPDPHGRPLRTYDDPGYVPLCETLADVRANIDRLDDEIVRLIAERAMYVKDAARFKGDAFQVSAPARQEEVFAKARALAQRHNRGFENLDQVVDATYRAMVAAFIANEQHYFNTMKKIGDSK
>NZ_CP021110.1|WP_086059597.1|3960904_3961849_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MGIAMLAPVAAAHAADWPSQPFRVLVPYGAGSSPDQVARIVSEKAGAILGQTMVVENKPGAGGNIGTFAIASAKPDGYTFGVSITGPLVNNTLLFDKLPYDPKRDLAPLTLAVHQPNVLVVPAKSGIQNVTQLLDEIRKNPDKFNFPSPGAGTVSHLAVELMLQQIGARAVHVPYPSSPAALTSVLSGDTQFAALPPIAVMPMVKDGRLRALAVTSSQRSSLLPDIPTLAEAGVQGVEGSAWIGFVISSQVPADIRQKLADALIQAIKDPEVAKRLRAQYMDPVGDTPQAFRAYMDDELKRWGPLIEKLGIKGQ
>NZ_CP021110.1|WP_086058721.1|3961865_3963206_+|FAD-dependent-oxidoreductase
MYVTEPSRRIAVHGEFDVVVLGGGPAGLLAAASAARNGASVLLIERYGFLGGMGTAAGVSNFCGLHANIHGDIQQVVHGMTDELLDRMRAMDGLNEPHLILGKIHAQAYDISAFKCAADGLLHDSGARVLFHAQACGVTRNDDGQLDAVILETKSGRQAVRARIFVDCTGDADLAHWAGLPYEKGDAQGHMLYPTLMFKVGNVDAARAQEAWKTIPQLMDQAEASGEFRFPRRGAIVRPQKHDYEWRVNVTQLCNADGSAADGTDAVSLSAGELEGRRQIVEYLKFLRAKVPGFENAYVLDIAPQLGIRETRRVVAEYMLSKEDVLGCADFEDSIGVNGWPLEIHMAGDVKWVWPPIPESRGYNQLPFRMIVPRRAADQPDNVLVAGRCAGMTHEGQSAARVSGSCFVMGEAAGTAAAMALQRGIAPRDLPAAELQRRLRQQGVWW
>NZ_CP021110.1|WP_086058722.1|3963628_3964816_+|3-hydroxybenzoate-6-monooxygenase
MSGTSHQSVIVVGGGIGGLAAALALARLGIRVQVLEQAAQIGEIGAGIQLGPNAFAALDALGVGENARKRAVFTDHIIMMDAVDAQEVVRIDTGEAFRERFGGPYAVIHRTDIHLSILEAVRENPLIGFKTSTQVAGLEQDGNGVEVIDTNGERYRADAVVGCDGVKSVIRQRLVGDEARVTGHVVYRAVVERDNMPEELRINAPVLWAGPRCHLVHYPLRGGQQFNLVVTFHSREQEVWGVREGSKEEVLSYFQGIHPRPHQMLDRPTSWKRWATADRDPVERWGEGRATVLGDAAHPMVQYMAQGACMALEDAVTLGAAVRACDMDLEAGFRRYESVRIPRTARVVWSTREMGRIYHAQGVERLVRNSLWEGRTQSQFYDALQWLYGWRVPTF
>NZ_CP021110.1|WP_086058723.1|3964897_3965902_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MFPKTSGRLGRILACGALALAAVAPVASHADDYPSKPLRFIVPYPPGGPLDTMARMLAEKVRGDLGQPVIVENRSGAGGNIGADLAAKAQPDGYTLVMGAVATHAINPWLFSNLPYDPVKDFAPVTLVASVPNVLVVNVDFAKNNNIRNLGDLIAYAKANPGKLNYGSGGNGSAGHLAGELLKARAGIKVEHIPYQGAAPAQLALLSGQSDFMFDNLAASAPLIKDGKVKVLAVTTKARSSILPEVPTVEEAGVKNFDLGTWFGVFTTGGTPQPVVDKLNKAYSAALMQPDVRQRLLLMGSDAKPMSSAQFADFVRSEKDKYKEIVKVSGASLN
>NZ_CP021110.1|WP_086058724.1|3966197_3966938_-|amino-acid-ABC-transporter-ATP-binding-protein
MAEAIIRMQGVNKWYGQFHVLRNINLDVAPGERIVICGPSGSGKSTLIRCINRLEEHQQGQIVVNGTELTNDLKHIETIRREVGMVFQHFNLFPHLTVLENLTLGPMWVLKKPRAEAEATALKYLERVRIPEQANKFPGQLSGGQQQRVAIARSLCMSPKIMLFDEPTSALDPEMVKEVLDVMVKLAEESGVTMLCVTHEMGFARKVADRVIFMDRGEIIEQNTPDAFFDRPQNERTKLFLSQILH

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Crispr_ID: NZ_CP021110_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_8

3963362-3963449

Orphan

Consensus_repeat	Method
GGGGGCGCGCCTGCGGACCGGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_8

>merge|NZ_CP021110|8|3963362-3963449|CRISPRCasFinder
GGGGGCGCGCCTGCGGACCGGAGGGAAAGCCCACCCCCGAAGCGCTACCGCGCTTCCCCCTCAGGGGGGCGCGCCTGCGGACCGGCGG

>NZ_CP021110|8|8|3963362-3963449|CRISPRCasFinder
GGGGGCGCGCCTGCGGACCGGAGG	GAAAGCCCACCCCCGAAGCGCTACCGCGCTTCCCCCTCAG
GGGGGCGCGCCTGCGGACCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086058716.1\|3953044_3953959_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274127
NZ_CP021110.1\|WP_086058721.1\|3961865_3963206_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_CP021110.1\|WP_086058718.1\|3956736_3957435_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP021110.1\|WP_086059598.1\|3966994_3968023_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP021110.1\|WP_086059600.1\|3969413_3970430_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270410
NZ_CP021110.1\|WP_086058725.1\|3970659_3971334_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|225438
NZ_CP021110.1\|WP_086058723.1\|3964897_3965902_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP021110.1\|WP_086059595.1\|3958794_3959772_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP021110.1\|WP_086058722.1\|3963628_3964816_+\|3-hydroxybenzoate-6-monooxygenase	unknown	unknown	gnl\|CDD\|181262
NZ_CP021110.1\|WP_086058724.1\|3966197_3966938_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP021110.1\|WP_086059596.1\|3959818_3960457_+\|maleylacetoacetate-isomerase	unknown	unknown	gnl\|CDD\|273527
NZ_CP021110.1\|WP_086058728.1\|3973267_3976903_-\|indolepyruvate-ferredoxin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|236404
NZ_CP021110.1\|WP_086055842.1\|3955417_3956374_+\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP021110.1\|WP_086059597.1\|3960904_3961849_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP021110.1\|WP_086058717.1\|3954147_3955200_+\|gentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|131325
NZ_CP021110.1\|WP_086059599.1\|3968156_3969347_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226960
NZ_CP021110.1\|WP_086058727.1\|3972521_3973157_+\|chemoreceptor-glutamine-deamidase-CheD	unknown	unknown	gnl\|CDD\|237398
NZ_CP021110.1\|WP_086058720.1\|3960488_3960863_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|214841
NZ_CP021110.1\|WP_086058719.1\|3957474_3958737_+\|flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236046
NZ_CP021110.1\|WP_086058726.1\|3971330_3972239_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225088

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086058716.1\|3953044_3953959_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|274127	TIGR02424, TF_pcaQ, pca operon transcription factor PcaQ. Members of this family are LysR-family transcription factors associated with operons for catabolism of protocatechuate. Members occur only in Proteobacteria. [Energy metabolism, Other, Regulatory functions, DNA interactions].	8.2711e-45
NZ_CP021110.1\|WP_086058721.1\|3961865_3963206_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	5.88598e-136
NZ_CP021110.1\|WP_086058718.1\|3956736_3957435_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	5.8623e-90
NZ_CP021110.1\|WP_086059598.1\|3966994_3968023_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.00468e-68
NZ_CP021110.1\|WP_086059600.1\|3969413_3970430_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270410	cd13692, PBP2_BztA, Substrate bindng domain of ABC glutamate/glutamine/aspartate/asparagine transporter; the type 2 periplasmic binding protein fold. BztA is the periplamic-binding protein component of ABC transporter specific for carboxylic amino acids, glutamine and asparagine. The BZtA domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.06361e-131
NZ_CP021110.1\|WP_086058725.1\|3970659_3971334_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	5.23397e-99
NZ_CP021110.1\|WP_086058723.1\|3964897_3965902_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	6.63226e-142
NZ_CP021110.1\|WP_086059595.1\|3958794_3959772_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	4.09814e-137
NZ_CP021110.1\|WP_086058722.1\|3963628_3964816_+\|3-hydroxybenzoate-6-monooxygenase	gnl\|CDD\|181262	PRK08163, PRK08163, 3-hydroxybenzoate 6-monooxygenase.	0
NZ_CP021110.1\|WP_086058724.1\|3966197_3966938_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	7.53405e-164
NZ_CP021110.1\|WP_086059596.1\|3959818_3960457_+\|maleylacetoacetate-isomerase	gnl\|CDD\|273527	TIGR01262, Maleylacetoacetate_isomerase, maleylacetoacetate isomerase. Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. [Energy metabolism, Amino acids and amines].	4.76172e-105
NZ_CP021110.1\|WP_086058728.1\|3973267_3976903_-\|indolepyruvate-ferredoxin-oxidoreductase-family-protein	gnl\|CDD\|236404	PRK09193, PRK09193, indolepyruvate ferredoxin oxidoreductase; Validated.	0
NZ_CP021110.1\|WP_086055842.1\|3955417_3956374_+\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.48556e-21
NZ_CP021110.1\|WP_086059597.1\|3960904_3961849_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	8.20541e-119
NZ_CP021110.1\|WP_086058717.1\|3954147_3955200_+\|gentisate-1,2-dioxygenase	gnl\|CDD\|131325	TIGR02272, gentisate_12-dioxygenase, gentisate 1,2-dioxygenase. This family consists of gentisate 1,2-dioxygenases. This ring-opening enzyme acts in salicylate degradation that goes via gentisate rather than via catechol. It converts gentisate to maleylpyruvate. Some putative gentisate 1,2-dioxygenases are excluded by a relatively high trusted cutoff score because they are too closely related to known examples of 1-hydroxy-2-naphthoate dioxygenase. Therefore some homologs may be bona fide gentisate 1,2-dioxygenases even if they score below the given cutoffs.	0
NZ_CP021110.1\|WP_086059599.1\|3968156_3969347_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|226960	COG4597, BatB, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.93106e-164
NZ_CP021110.1\|WP_086058727.1\|3972521_3973157_+\|chemoreceptor-glutamine-deamidase-CheD	gnl\|CDD\|237398	PRK13489, PRK13489, chemoreceptor glutamine deamidase CheD; Provisional.	6.87694e-102
NZ_CP021110.1\|WP_086058720.1\|3960488_3960863_+\|chorismate-mutase	gnl\|CDD\|214841	smart00830, CM_2, Chorismate mutase type II. Chorismate mutase, catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine..	8.6992e-15
NZ_CP021110.1\|WP_086058719.1\|3957474_3958737_+\|flavin-dependent-oxidoreductase	gnl\|CDD\|236046	PRK07538, PRK07538, hypothetical protein; Provisional.	0
NZ_CP021110.1\|WP_086058726.1\|3971330_3972239_+\|FtsX-like-permease-family-protein	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	8.93637e-50

>NZ_CP021110.1|WP_086058721.1|3961865_3963206_+|FAD-dependent-oxidoreductase
MYVTEPSRRIAVHGEFDVVVLGGGPAGLLAAASAARNGASVLLIERYGFLGGMGTAAGVSNFCGLHANIHGDIQQVVHGMTDELLDRMRAMDGLNEPHLILGKIHAQAYDISAFKCAADGLLHDSGARVLFHAQACGVTRNDDGQLDAVILETKSGRQAVRARIFVDCTGDADLAHWAGLPYEKGDAQGHMLYPTLMFKVGNVDAARAQEAWKTIPQLMDQAEASGEFRFPRRGAIVRPQKHDYEWRVNVTQLCNADGSAADGTDAVSLSAGELEGRRQIVEYLKFLRAKVPGFENAYVLDIAPQLGIRETRRVVAEYMLSKEDVLGCADFEDSIGVNGWPLEIHMAGDVKWVWPPIPESRGYNQLPFRMIVPRRAADQPDNVLVAGRCAGMTHEGQSAARVSGSCFVMGEAAGTAAAMALQRGIAPRDLPAAELQRRLRQQGVWW
>NZ_CP021110.1|WP_086059597.1|3960904_3961849_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MGIAMLAPVAAAHAADWPSQPFRVLVPYGAGSSPDQVARIVSEKAGAILGQTMVVENKPGAGGNIGTFAIASAKPDGYTFGVSITGPLVNNTLLFDKLPYDPKRDLAPLTLAVHQPNVLVVPAKSGIQNVTQLLDEIRKNPDKFNFPSPGAGTVSHLAVELMLQQIGARAVHVPYPSSPAALTSVLSGDTQFAALPPIAVMPMVKDGRLRALAVTSSQRSSLLPDIPTLAEAGVQGVEGSAWIGFVISSQVPADIRQKLADALIQAIKDPEVAKRLRAQYMDPVGDTPQAFRAYMDDELKRWGPLIEKLGIKGQ
>NZ_CP021110.1|WP_086058720.1|3960488_3960863_+|chorismate-mutase
MQEPDPHGRPLRTYDDPGYVPLCETLADVRANIDRLDDEIVRLIAERAMYVKDAARFKGDAFQVSAPARQEEVFAKARALAQRHNRGFENLDQVVDATYRAMVAAFIANEQHYFNTMKKIGDSK
>NZ_CP021110.1|WP_086059596.1|3959818_3960457_+|maleylacetoacetate-isomerase
MQLYSFFNSSTSYRVRIAMALKGLRYDYLPVNIRVLEHRKDDYVDRNPSASVPLLVDGEMNLGQSLAIIDYLDAAHPKPRLLPQDPALRARVLEVSSVIACDMHPVNNLRILRYLQDVLGVSAEQKNAWYAHWIREGMTAVETLLQRHGSGAYCFGDAPTLADCCLVPQIANAERMGCDMSAYPRAMAVYAHCQAQPAFQQAAPRNQPDFIA
>NZ_CP021110.1|WP_086059595.1|3958794_3959772_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MIATCRALAAWSVGLVMALTAAASQAAWPERPVTLVVPFTPGTGIDLIARQLSAALPKTLGQPVVVENLAGASGNIGTEKVARAAPDGYTFLVTVNTFVMNQPLYREKLHYDPVKDFAPVSLTSWGTLLLVTHPSNPVNTVRQMEDAARKQPGKLTYGTPGVGTPHHLAMALLLDQTKVSLLHVPYKGTAGAVTDMLAGRLDYMFLPVHVALPQIKAGKLKAIATGSPKRMPQLPDVPTLTESGLQGADVDMWYGVLAPRGTPKEVVDSLNRQIAEALKAPSVATAFEAQGMVPATSTPEEFGALIAKDAKRWSDVVDRAGIKAD
>NZ_CP021110.1|WP_086058719.1|3957474_3958737_+|flavin-dependent-oxidoreductase
MKDTDVIIVGAGVGGLVLALSLHQAGIACRVYEAVPEIKPLGVGINLLPHAARELDELGLLPALDRVGVHTRESIFFTRHGQLIYSEPAGKAAGYAWPQYSIHRGDLQMTLLAAVRERLGEDNVRVDHRAVRVEQDDDAVTVHMTDSAGNPRPPVRGAIVVGCDGIHSALRKQLYPNEGAPRYSGVNMWRGVTRCKPFLSGASMVRAGWLSIGKMVIYPIRDNVDAEGNQLVNWVAEIESPEPAVRDWTRQGRLEDFFPAFADWRFDWLDVAALIRNADSVLEYPMVDQDPLPTWTQGRMTLLGDAAHPMVPRGSNGAGQAIIDARYLAGQLKRQGLTPAALQDYDRVRVAATTRVVLTNRSNPPDAILREAYERSHDQPFDRIEDIISRDELQAISDRYKQIAGFDPETLSSRPSFLSV
>NZ_CP021110.1|WP_086058718.1|3956736_3957435_+|fumarylacetoacetate-hydrolase-family-protein
MSYVFAPPTIVAVPVAGSADSFPVRRVYCVGRNYAAHAREMGFDPDREPPFFFCKPADAVMPVAEGETLELPYPAETANYHYEIELVAAIGKAGANISVDSALDHVYGYAVGLDMTRRDLQMKMREAGRPWELGKAFDDSAPIGPIHTVAAKGHHDQAGIWLKVNGQDKQRSDTSKLIWSVAETIAYLSRYFRLAPGDLIYTGTPEGVGPVVKGDLMEGGVDGLGTLRARVI
>NZ_CP021110.1|WP_086055842.1|3955417_3956374_+|transposase
MSEATYVGIDVSSEVLEIAVSTQPSTWQASNDSGGIEQLAGQLQALRPALVVLEATGGYEFEAACVLQAQGLAVAVVNARMARDFARAMGALGKTDALDARMLATFARVLDQHPDRARFVKPLADAQLQRLQALVLRRRQIVQTMTSERHRLRISHEAARPSIERHLAFLRQELDDSDGHIAEHVQQHQAELARVLSSVPGIGAASVALLLAELPELGRLDRRRIAALVGVAPVNRDSGKMRGQRSIWGGRASVRCALYMASLSAVRYNPVLRAYYQRLLGTGKKKKVALVATMRKLLTILNAMVRHNKQWEPALDCP
>NZ_CP021110.1|WP_086058717.1|3954147_3955200_+|gentisate-1,2-dioxygenase
MAEGTSTRADRAAYYERIARKNLAPLWESLHNLVPRTPQPRCVPAMWRYNDVRADVMEAGSLITAEEAVRRVLILENPGLPGQASITQTLYAGLQLILPGEIAPSHRHTQSALRFIMEGKGAYTAVNGERTTMHPGDFIITPSWTYHDHGNLEASEGGEPVVWLDGLDIPLLRMLDAGFAENYPASTQPVTRPEGDSYARYGYNMAPVRYQPANGNSPIFNYPYERSREALDRLYRFGELDAWDGVKLRYINPATGGSPMPTMATFMQFLPAGFQGKTTRSTDSTVYSVVEGRGTARVGDQEFHFGPRDVFVAPSWQPVQLAAAEDAILFSFSDRPVQMALGLLREERLE
>NZ_CP021110.1|WP_086058716.1|3953044_3953959_-|LysR-family-transcriptional-regulator
MDWTYRLRLRNLKMLLSLAQTRNISHSAAMLNTTQPGLSKWLKDLEDDIGLPLFERHARGLRPTPYGEALIAHARRIDAQLERASGDMAALRQGGGGRVVIGASGASASDTVPLAVMRLLERMPQARIKLVESTMDHLLAQLAQGELDIVVGRSAPEHHDPAILSESLYLEPVHMVARPRHPVFSLPSVTWEDLMDYRWIVWPKGTPIRNALDTALAAAGKALPADHVESNSVTINLTLISQSDLIGVASHRAALRFAQMNAMRILPVRLSGFGAVTMYWRQETFQPAAVEAALECLRGVVAEP
>NZ_CP021110.1|WP_086058722.1|3963628_3964816_+|3-hydroxybenzoate-6-monooxygenase
MSGTSHQSVIVVGGGIGGLAAALALARLGIRVQVLEQAAQIGEIGAGIQLGPNAFAALDALGVGENARKRAVFTDHIIMMDAVDAQEVVRIDTGEAFRERFGGPYAVIHRTDIHLSILEAVRENPLIGFKTSTQVAGLEQDGNGVEVIDTNGERYRADAVVGCDGVKSVIRQRLVGDEARVTGHVVYRAVVERDNMPEELRINAPVLWAGPRCHLVHYPLRGGQQFNLVVTFHSREQEVWGVREGSKEEVLSYFQGIHPRPHQMLDRPTSWKRWATADRDPVERWGEGRATVLGDAAHPMVQYMAQGACMALEDAVTLGAAVRACDMDLEAGFRRYESVRIPRTARVVWSTREMGRIYHAQGVERLVRNSLWEGRTQSQFYDALQWLYGWRVPTF
>NZ_CP021110.1|WP_086058723.1|3964897_3965902_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MFPKTSGRLGRILACGALALAAVAPVASHADDYPSKPLRFIVPYPPGGPLDTMARMLAEKVRGDLGQPVIVENRSGAGGNIGADLAAKAQPDGYTLVMGAVATHAINPWLFSNLPYDPVKDFAPVTLVASVPNVLVVNVDFAKNNNIRNLGDLIAYAKANPGKLNYGSGGNGSAGHLAGELLKARAGIKVEHIPYQGAAPAQLALLSGQSDFMFDNLAASAPLIKDGKVKVLAVTTKARSSILPEVPTVEEAGVKNFDLGTWFGVFTTGGTPQPVVDKLNKAYSAALMQPDVRQRLLLMGSDAKPMSSAQFADFVRSEKDKYKEIVKVSGASLN
>NZ_CP021110.1|WP_086058724.1|3966197_3966938_-|amino-acid-ABC-transporter-ATP-binding-protein
MAEAIIRMQGVNKWYGQFHVLRNINLDVAPGERIVICGPSGSGKSTLIRCINRLEEHQQGQIVVNGTELTNDLKHIETIRREVGMVFQHFNLFPHLTVLENLTLGPMWVLKKPRAEAEATALKYLERVRIPEQANKFPGQLSGGQQQRVAIARSLCMSPKIMLFDEPTSALDPEMVKEVLDVMVKLAEESGVTMLCVTHEMGFARKVADRVIFMDRGEIIEQNTPDAFFDRPQNERTKLFLSQILH
>NZ_CP021110.1|WP_086059598.1|3966994_3968023_-|amino-acid-ABC-transporter-permease
MRARLFSSPLNILLTVLIAWFLLLAVPALAEWLVIRANFSASTAQECRASAGACWAFIREKHRLILFGTYPYDEQWRPLLASVVLVAVVVCSGIRRFWRPKLAILWIAGLAVVAVLMWGGVFGLTYVENARWGGLPLTLILATFGIAFAFPIGVLLALGRRSRLPAIKALCVVYIELIRGVPLISLLFMSSVMLPLFLPEGYSIDKLLRAQIAIIMFAAAYIAETVRGGLQAIPKGQYEGAASLGLTYWQQMRKIILPQALRIVIPPLVGIFISLFKDTSLVVIIGIFDLTLAAKAALSDAAWRGFGVEAYLFIAFIYFIFCFSMSKYSQALERRLAQGYQR
>NZ_CP021110.1|WP_086059599.1|3968156_3969347_-|amino-acid-ABC-transporter-permease
MTPAFKAPPNGAPVRKLSWNDPGVRSIVYQIVAVAIVAWVAWFLVSNTLHNLSSRNISTGFGFLGREAGFAIGETAIRYTPADTYGRAVMVGILNTLRVAVTGIVLATLLGTLIGIARLSRNWLVSRLASLYVEVMRNIPLLLQLFFWYALITENMPGPRQAHQPMPGVFISNRGLKLPSLQGDALDWMLGGLGLAIALTLALAHWGNKRREATGRIFPLTRWAIGLIIALPLLGWLASGASLSLDVPVLRGFNFAGGVTLTPEFAALLAGLVIYTSAFVAEVVRSGIQAVNIGQWEAAGSLGLRRSLVLRLVVLPQALRVIIPPMTSQYLNLTKNSSLAVAIGYPDIVSVVNTTLNQTGQAIEGILIIMAAYLTVSLTISVLMNWYNKRIALVER
>NZ_CP021110.1|WP_086059600.1|3969413_3970430_-|amino-acid-ABC-transporter-substrate-binding-protein
MKTWKSAALGAALLAVCGLAHAGATFDNVKKKGFVQCGVSTGVPGFSSPDSKGEWKGLDVDMCRAIAATMFNDASKFKITPLNTQQRFTALQSGEIDVLTRNTTETLTRDTTLGLLGTGVNYYDSQGVMVSKDLGVKSAKDLNGATVCVQPGTTTELNLADWFRSNKIEFKPVVIEKYDEIVRAFSAGRCDAFTTDKSQLASTRTTLENPDKYIILPEDFSKEPLGPMVRQDDVQWFNVVRWTLNAMLEAEEYGITSQNVDQMLKSANPNVQRILGVTPGMGKNLGVDDKWAYNIVKQVGNYGESFERNLGGGSLMKLPRGLNAPWKQGGLMYGWPIR
>NZ_CP021110.1|WP_086058725.1|3970659_3971334_+|ATP-binding-cassette-domain-containing-protein
MIEFQHVFKSYGRGRNILADINFRITAGEFVFVSGPSGAGKSTLLKLIGGLEPPSRGSIQVNGQRLDKLPQRARPYLRRAVGVILQDTHLLYDRNAFENVMLPLAVTGQPWDSAAARARAALEKVGLSGKESLNPIELSGGEQQRLAIARAIVNRPAILIADEPTANLDHDSALRIMNVFRDFNRVGVTTLIASHDQELMSHYAQRVLRIEPGRFADLSQETQP
>NZ_CP021110.1|WP_086058726.1|3971330_3972239_+|FtsX-like-permease-family-protein
MNAWLRQHRYALGITLRRMLAQPFSSLANLLVMALALALPVLGAAILVSVQPVARQLSVTPELTVFMKVDAPAGAAASVADRIRKEFGDQVREVRTVGRDAALADLRRDPAWAQALAVLPGNPLPDAVVATLRDGEDLAGRAARLAQAWKGWDQVEQVQLDSAWVQRMEALLRFGRIGLIFLAACVAVVVLATVFNTVRMQALTQREEIAVARLVGATESFVRRPFLYLGALSGALAALLGIAIAAIALSPLNEALLALARSYGADFALHMPEAPWLALAVVAAAVLAALSARWSVTRSTRF
>NZ_CP021110.1|WP_086058727.1|3972521_3973157_+|chemoreceptor-glutamine-deamidase-CheD
MSARDARATRHYFDSAFNYQAVKVLPNEYYVTGDDLMITTVLGSCVAACIRDPQTGVGGMNHFMLPEGDSQSPASATMRYGAFAMEVLINEVLKAGAARERLQAKVFGGGAVLEAMHQLNIGERNGHFVLNYLKMEGIPVLAQDLGDVYARRISFFPRDGRVMVRKMTTKPRAIEIIAKREVAVAETLKEKTVAKPKVERFAMPARRAPAV
>NZ_CP021110.1|WP_086058728.1|3973267_3976903_-|indolepyruvate-ferredoxin-oxidoreductase-family-protein
MNAPLTPAQRAALDAVQLDDKYSLETGRAWMSGIHALVRLPMMQRMRDVRAGLNTAGFISGYRGSPLGGVDLNMWKAEKYLKAHHVVFQPGLNEDLAATAVWGSQQVNLFPGARYDGVFGMWYGKGPGVDRCGDVFKHANAAGTSRHGGVLVVAGDDHPAKSSTLPHQSDHLLKACLIPVLFPSTVQEVLDYGLHGWAMSRYAGVWVGMKCITDIVEVSASVEVDPERVSIVLPEDFRMPPDGLNIRLPDTPLEQEARLLDFKLYAALAYARANSLNRELWHVPTESARFGIMTSGKAYLDTRQALSDLGLDDETCRRIGVRLFKVGMVWPLEATGMQRFAEGLDEILVVEEKRQVLEYQLKEELFAWVGSGKKIPRVVGKFDDKDGGEWAVPQGNWLLPAHYEFSPAIVAKAIGSRLLKFELPPDVRAGIEARLAFIEARERALSRPRVVAERKPWFCSGCPHNTSTRVPEGSRGMAGIGCHYMVRWMGRSTDLFTHMGGEGVPWIGHAPFTEEKHVFANLGDGTYYHSGLLAIRAAVAAKTPITYKILFNDAVAMTGGQPVDGPISVPMITRQMAAEGIEKIIVVTDEPEKYKTMQGMAPGVPVVHRNELDRVQRELREYPGVSILIYDQTCATEKRRRRKHNAYPDPARRVVINDRVCEGCGDCSDKSNCLSVEPLETEFGRKRTINQSSCNKDFSCLNGFCPSFVTVEGGKLRKPKGIGAQNAIDRDLPEPQQPGLERPYGVFIAGVGGTGVVTIGQLLGMAAHLEGKGCSVLDMAGLAQKGGAVHSHVILAQSPGHLLNTRVAMGEADLVLAGDLVVASSQDAVARMRPERTRLLLNSDVAPTAAFISNPDWRLPSDSLRRDIGAACMPGQVDAVDAAELAVGLLGDAIYANPLMLGYAYQKGWIPLGRDALLRAIELNGQQVENNKAAFAWGRRAAQDLAAVQRLIKPAALDEGEGRQGGAEIIEIRRGANTSDTAGVRRLPADVAALVEKRQRFLTEYQNSAYARRYVDFVEQVAAAEQGAAGTSRLTLAVARNLFKLMAYKDEYEVARLYSDGVFLRKVAEQFEGDWKLSFHLAPPAFSRRDANGHLVKRAYGPWMMKAFGLLRKGRFLRGTAFDPFGHTAERRKERALIAEYRETIASLLPRLSRANLDLAVALASLPEEIRGYGHIKEAAIARAEARRAELLRQLDVRGGETSGHGTVRAA

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Crispr_ID: NZ_CP021110_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_9

4063390-4063477

Orphan

Consensus_repeat	Method
AGGGGGCGCGCCGGTGGACCGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_9

>merge|NZ_CP021110|9|4063390-4063477|CRISPRCasFinder
AGGGGGCGCGCCGGTGGACCGGAGGGGAAGCCTCACCCCCGAAGCGCTAACGCGCTTCCCCCTCCAGGGGGCGCGCCGGTGGACCGGC

>NZ_CP021110|9|9|4063390-4063477|CRISPRCasFinder
AGGGGGCGCGCCGGTGGACCGGA	GGGGAAGCCTCACCCCCGAAGCGCTAACGCGCTTCCCCCTCC
AGGGGGCGCGCCGGTGGACCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086058782.1\|4050721_4051921_+\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|236985
NZ_CP021110.1\|WP_086058798.1\|4071071_4071812_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP021110.1\|WP_086058796.1\|4068623_4069847_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP021110.1\|WP_086058787.1\|4055110_4055896_+\|LamB/YcsF-family-protein	unknown	unknown	gnl\|CDD\|377121
NZ_CP021110.1\|WP_086058788.1\|4056708_4057632_-\|XamI-family-restriction-endonuclease	unknown	unknown	gnl\|CDD\|312917
NZ_CP021110.1\|WP_086058789.1\|4057628_4059215_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP021110.1\|WP_086058784.1\|4052883_4053327_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319945
NZ_CP021110.1\|WP_086058785.1\|4053357_4054026_+\|5-oxoprolinase-subunit-PxpB	unknown	unknown	gnl\|CDD\|367142
NZ_CP021110.1\|WP_086059609.1\|4055929_4056610_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP021110.1\|WP_086058783.1\|4051868_4052780_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176118
NZ_CP021110.1\|WP_086058793.1\|4065936_4066830_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP021110.1\|WP_086058800.1\|4072447_4073452_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176117
NZ_CP021110.1\|WP_086058797.1\|4069846_4071013_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP021110.1\|WP_086058799.1\|4071858_4072413_-\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_CP021110.1\|WP_086058794.1\|4067082_4067469_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380344
NZ_CP021110.1\|WP_086058786.1\|4054064_4055099_+\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224895
NZ_CP021110.1\|WP_086058790.1\|4059340_4063306_-\|FAD/FMN-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|378859
NZ_CP021110.1\|WP_086058795.1\|4067637_4068627_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP021110.1\|WP_086058792.1\|4064388_4065897_+\|threonine-ammonia-lyase,-biosynthetic	unknown	unknown	gnl\|CDD\|236417
NZ_CP021110.1\|WP_086058791.1\|4063628_4064150_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|224159

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086058782.1\|4050721_4051921_+\|phosphoglycerate-dehydrogenase	gnl\|CDD\|236985	PRK11790, PRK11790, phosphoglycerate dehydrogenase.	0
NZ_CP021110.1\|WP_086058798.1\|4071071_4071812_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.0769e-44
NZ_CP021110.1\|WP_086058796.1\|4068623_4069847_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.42644e-120
NZ_CP021110.1\|WP_086058787.1\|4055110_4055896_+\|LamB/YcsF-family-protein	gnl\|CDD\|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	7.03881e-146
NZ_CP021110.1\|WP_086058788.1\|4056708_4057632_-\|XamI-family-restriction-endonuclease	gnl\|CDD\|312917	pfam09572, RE_XamI, XamI restriction endonuclease. This family includes the XamI (recognizes GTCGAC but cleavage site unknown) restriction endonuclease.	2.13089e-72
NZ_CP021110.1\|WP_086058789.1\|4057628_4059215_-\|SAM-dependent-methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	4.51263e-10
NZ_CP021110.1\|WP_086058784.1\|4052883_4053327_+\|VOC-family-protein	gnl\|CDD\|319945	cd08357, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) familyprotein, glyoxalase I, and type I ring-cleaving dioxygenases. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.56527e-70
NZ_CP021110.1\|WP_086058785.1\|4053357_4054026_+\|5-oxoprolinase-subunit-PxpB	gnl\|CDD\|367142	pfam02682, CT_C_D, Carboxyltransferase domain, subdomain C and D. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the C and D subdomains of the CT domain. This domain covers the whole length of kipI (kinase A inhibitor) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	2.66297e-85
NZ_CP021110.1\|WP_086059609.1\|4055929_4056610_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.23753e-27
NZ_CP021110.1\|WP_086058783.1\|4051868_4052780_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176118	cd08427, PBP2_LTTR_like_2, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.69902e-69
NZ_CP021110.1\|WP_086058793.1\|4065936_4066830_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.39979e-66
NZ_CP021110.1\|WP_086058800.1\|4072447_4073452_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176117	cd08426, PBP2_LTTR_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.0468e-39
NZ_CP021110.1\|WP_086058797.1\|4069846_4071013_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	8.80112e-103
NZ_CP021110.1\|WP_086058799.1\|4071858_4072413_-\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	4.09149e-91
NZ_CP021110.1\|WP_086058794.1\|4067082_4067469_+\|cupin-domain-containing-protein	gnl\|CDD\|380344	cd02214, cupin_MJ1618, Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain. This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.	2.40969e-17
NZ_CP021110.1\|WP_086058786.1\|4054064_4055099_+\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	1.0729e-116
NZ_CP021110.1\|WP_086058790.1\|4059340_4063306_-\|FAD/FMN-binding-oxidoreductase	gnl\|CDD\|378859	pfam12447, DUF3683, Protein of unknown function (DUF3683). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam02754, pfam01565, pfam02913.	8.50516e-70
NZ_CP021110.1\|WP_086058795.1\|4067637_4068627_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.71904e-134
NZ_CP021110.1\|WP_086058792.1\|4064388_4065897_+\|threonine-ammonia-lyase,-biosynthetic	gnl\|CDD\|236417	PRK09224, PRK09224, threonine ammonia-lyase IlvA.	0
NZ_CP021110.1\|WP_086058791.1\|4063628_4064150_-\|DedA-family-protein	gnl\|CDD\|224159	COG1238, COG1238, Predicted membrane protein [Function unknown].	1.33397e-27

>NZ_CP021110.1|WP_086058790.1|4059340_4063306_-|FAD/FMN-binding-oxidoreductase
MNAPLASQLLNAAIPPAPGTRLREIPYNYTSFSDREIVGRLLGEDAWQLLTDLRSERRTGRSARMLYEVLGDIWVVSRNPYLQDDLLDNPKRRRMLIDALHHRLAEIDKRREPGRIEFQEGRDLYRDEKVLQLIERARAAVAAFEARFDETAQLRRQTQKTLGRITARDNIKFDGLSRVAHVTDATDWRVEYPFVVLTPDSEEEVAALVRGCFELGLTIIPRGGGTGYTGGAIPLTWKSAVINTEKFETLGKVELTTLPGVETPVATVFTGAGVVTKRVADAAAQAGYVFAVDPTSAEASCVGGNIAMNAGGKKAVLWGTALDNLAWWRMVDPDGNWLEVTRLGHNMGKIHDVEVARFELKWFDGRGKPGETLLRTEVLEIEGRRFRKEGLGKDVTDKFLAGLPGVQKEGCDGLITSARWVLHRMPAHTRTVCMEFFGQARDAIPSIVEVKHYLDHEGRQRGAILAGLEHLDERYLRAVGYATKSKRGVLPKMVLIGDIVGDDEDAVAAAASEVVRLANTRHGEGFVAVSAEARKKFWADRSRTAAIARHTNAFKINEDVVIPLNRMGEYTDHIERINIELSTRNKLRLLDELDAFLREPLPLGKAEDAEDAEITRAEVLAARTAQARALIAATRARWQWLLNELDKPLTQALPDMATLGLGHMQAALADRIAAQPGARVFDVVQDRTVRVSWKTEVLAELQRIFSGSACQKVLEEMRAIHARVLKSRVFVALHMHAGDGNVHTNIPVNSDDYGMLREANEAVERIMRIARDLDGVISGEHGIGLTKYEFLTQEELQPFQDYKRRVDPNGRFNAGKLMPGADLTHAWTPSFNLMGHESLIMQQSDIGAISASVKDCLRCGKCKPVCATHVPRANLLYSPRNKILATSLLVEAFLYEEQTRRGVSLKHWEEFEDVADHCTVCHKCYNPCPVDIDFGDVSMNMRALLRRMGRKSFNPGTSAAMFFLNAKDPATINLTRKAMVDVGYKVQRAAHDLLSGLARKQTRHPPATVGKRPIAEQVVHFVNKKMPGGLPKQTARKLLDIEDPDYVPIIRDPRATSADSEAVFYFPGCGSERLFSQVGLATQAMLWHAGVQTVLPPGYLCCGYPQRGAGMNDKADQIITDNRVLFHRVANTLNYLDIKTVVVSCGTCYDQLAGYEFDKIFPGCRLIDIHEYLLEKGIKLDGVQGVRYMYHDPCHTPMKLQDPMKTVKSLVGDGAIKSDRCCGESGTLAVSRPDVSTQVRFRKEEELRKGGDAIRADGFNGEVKVLTSCPSCLQGLSRYKGDTAMDADYIVVEMARHILGEDWMQNYVKQANAGGIERVLV
>NZ_CP021110.1|WP_086058789.1|4057628_4059215_-|SAM-dependent-methyltransferase
MKLQTEQDLVGLCLALIGGQAGLTPNERRLARQAHGLVPGPREIERVRASINRGSDPLGDAFSSIRGAVDRRADGAIYTPAPIVRAMTSWLAGEAVPARIVDPGAGSGRFILAAGERFPDAALVAVEVDPLAALMLRANLAARGWTDRATVLVKDYRDIRLPRCAGTTAFIGNPPYVRHHDIGEAWKAWYARKFAQFGIKASSLAGLHLHFFLQTRLLARPGDVGVFITSAEWLDVNYGVALRKLLLDELGGLALHVLEPRVEAFPGTATTAAITCFRIGEQDEPVRVRAVDRLAQLNGLKKGVSVPRQQLQAAPRWSIIVRPSPAVAGGEIELGELFRVHRGQVTGANNIWIAGEHARALPDSVKLPAVTKARELIQAGADLRSAADLRRVIDLPPELDGFSRDERERIDAFLAWARRCGADQGYIARHRKAWWSVGLKAPAPILCTYMARRPPQFTRNSCDARHINIAHGLYPRTPLDPAILASLVAWLNTNIRTGSGRTYAGGLTKFEPREIERLRIPGPDTLLA
>NZ_CP021110.1|WP_086058788.1|4056708_4057632_-|XamI-family-restriction-endonuclease
MIRVPHRWSAAELAQEAAIAAAQFRAERLAASDSWQTHYDDARSKFELLFGKLDDLAPGAITDDKLADAYGAGLGEAMRYLAGPPISEDDLRVIADVESTAPGVLRKDRNALRKVFDVIERVIDPHRFPWVERGEAPTAPQREAALLASSVLLAAQRIATERRNEGKDTQETKVKDYLRSLGFTEAPAMPINTIVRGPQPMQFCAECQLGERKADVVVRLHDTRLLAIECKVSNSATNSVKRLNNDAAVKAEYWIKQFGTAQVVPAAALAGVFKVLNLEQAQTRGLSLFWSHDLGKLGEFIATTAAT
>NZ_CP021110.1|WP_086059609.1|4055929_4056610_-|GntR-family-transcriptional-regulator
MDIKPPATIPFVLYERIRQMIIDGTLAPGQPLREQELERRFGTSRSPIREALRLLQLNGLATHQQRRGFRVVLYTEREIAQIYLLRGELESYAMREVARCDDVEPLLSSLRDACERLAARDPLRDAASHLSIMRDAFLHIVEFVQNPPLAEAVKRLNERCEPLRYNLSRQGADVGALAGYLRRILQALERRDFDGAAAARRECARWILPLVVRAYAAQLNDAQPAR
>NZ_CP021110.1|WP_086058787.1|4055110_4055896_+|LamB/YcsF-family-protein
MALSIDLNCDMGESYGAWRMGNDEEVLQYVSSANIACGFHGGDPGTMRRTVAAALAKGVALGAHPSLPDLAGFGRRVMQITPSEAYDMVVYQIGALSAVAASQGARLHHVKAHGALYNMSAKDVALSEAICRAIRDVDASLVLYGLAGSEHIRAAEKIGVEVAQEVFGDRSYQNDGSLTPRSRPGAMIEDLDTAVAQVLRMVTEGKVRSVDGNDVPVKADTLCIHGDQPGALAFAAGIRSALEKAGVAVRTVGATAAEPAA
>NZ_CP021110.1|WP_086058786.1|4054064_4055099_+|biotin-dependent-carboxyltransferase-family-protein
MSLCVLKPGLLSSFQDLGRFGYQHQGIPVAGAMDARAHRLASLLAGNDPARTASLEITLQGPVLRFEQAACFALSGASLGAALNGKAIPINRPLLARAGDILAFGAAGGDASLDGAQGLRAYLAVHGGFSLRRVMDSESTYLRSGFGGYEGRALAKGDVVGLRRAVNATALDELENALWQTRLYLPGTLTAQPRATVRAVPGRQWDDFTQAARDAFAGEPYVVTPQSERMGYRLQGPALAMTQPRQMLSEATCFGTVQVPADGAPIVLMADRQTTGGYPKIAQVASVDLPRLAQTAPGSTIRFEMISLDQAQRLDGERETAFARLADALQGLRALYARHTSESQ
>NZ_CP021110.1|WP_086058785.1|4053357_4054026_+|5-oxoprolinase-subunit-PxpB
MPAPDWRIHPQGDRCLLVTFGESIDAETGRRCLAVARLLRGAGLPGVTDVVPSFVAVAVHYAPGPDGAGPTYLELAGRIEAMLHAGIPAGEDTARDIEIPVHYGGEHGPDLEDVARATGLTPDEVIALHTQPGSMVFMLGFAPGHPYIGVHDERLNVPRRATPRTAVPMGSVAIANRQTVIYPSRLPGGWNVIGVTPLRLFDPAREPASLLQPGDRVRFVAL
>NZ_CP021110.1|WP_086058784.1|4052883_4053327_+|VOC-family-protein
MSAQPSAQPAMPPFHLAFPVRDIAEARRFYGELLGCPEGRSAPEWVDFNFYGHQIVAHLAPEECGHKQTSPVDGHDVPVRHFGAVLSMPEWEAVADKLTKAGTKFVIEPYIRFKGEVGEQATMFFLDPSGNALELKAFKNMDMLFAK
>NZ_CP021110.1|WP_086058783.1|4051868_4052780_-|LysR-family-transcriptional-regulator
MLTEFRTFVAVARDGTFTGAGRQLGLTQSAVSAQIRRLEEFLGVSLFDRTGRAAALNDTGREMLAQAEEVLAMVDRMAAQAGPGHVTGSLRMGAIASVQQDLMVTALRGFRAEFPDVSVRIVPGVSLSLLGQVDSGEIDLAVLIRPPFKLPPELAWRPLLAEPMVLAAPASLAGLSWRDALTTQPFIRYERASFGGRLVDAFLRRHRIAVHEAVELDEIDAIANLVRAGLGVALMPRTRQLNTAGLRLLDLGAAGFDREIGVAIRRSADPAGVAARMAGCLHEAAAIRSAGSESSPGGRTATS
>NZ_CP021110.1|WP_086058782.1|4050721_4051921_+|phosphoglycerate-dehydrogenase
MTRIVLFENIHPSGVAVFRDAGYTDVRTYSSSLPPSELRAALEGADVVGIRSRTHLDAGIFETFTRLQVVGCFCIGTNQVDLDSALHHGVPVFNAPFSNTRSVAELVLAEAVLLLRRIPEKNLRVHQGHWDKTASGAYEARGKTMGVIGYGNIGSQVGTLAESMGMRVVYYDVEAKLPLGNAHPVNTLAELLAQSDVVTLHVPGGRSTENIMNAETLAQMKRGAILINASRGTVVDIEALHQALTSGHLAGAALDVFPTEPKSVDEPLASPLIGMPNVILTPHIGGSTQESQENIGREVAEKLVRYLQSGTTKGAVNFPELPFTERSGSARILHIHKNVPGALGTLDNLLAQHHLNIVSQNLQTRGDIGYVVTDVDGEVNDDIMKSLCAHPVTIRCQRI
>NZ_CP021110.1|WP_086058791.1|4063628_4064150_-|DedA-family-protein
MEAALMSAVNWLLGALALPNVGLSAIFIVSLISATLLPLGSEPAVFGYVKLAPDMFWPAVLVATAGNTVGGAISYAMGWGAWRAAERWKEKHPHRAHEARTHAGHGRWHRRAHDWLHRMGPPALLLSWVPAIGDPLCAVAGWLRLPFWPCVLYMGIGKFLRYLAMTGGLLWLF
>NZ_CP021110.1|WP_086058792.1|4064388_4065897_+|threonine-ammonia-lyase,-biosynthetic
MSTDYLKRILTSKVYDVAVESPLEPATLLSQRISNTVLLKREDAQPVFSFKLRGAYNKMANMPPAALARGVIAASAGNHAQGVALSARKLGCRAVIVMPTTTPEVKIDAVRRLGGEVVLAGESFSDAYAHAKELEKKQKLTFVHPFDDPDVIAGQGTVGMEILRQHPGPLDAVFVAIGGGGLIAGVATYIKQLRPEVRIIGVQTEDSDAMLRSVRAGRRVVLNDVGLFSDGTAVKQVGAETFKLVRQYVDDFVVVDTDAICAAIKDVFQDTRSVLEPAGAMAVAGAKQYLAQQKWKNKTVAAIACGANMNFDRLRFVAERAEVGEMREAVFVVSMPEQRGSFRKFCELVGNRNVTEFNYRISDAVRAHVFVGIQVSSPAEPEKLAANFRRHGFDTLDLTHDEMAKTHLRHMVGGRSALAHDELLYRFEFPERPGALMRFLSTMNPSWNISLFHYRNQGADYGRILVGIQVPPSDKKAFKAFIAELAYPCWNETDNPAYKLIL
>NZ_CP021110.1|WP_086058793.1|4065936_4066830_+|LysR-family-transcriptional-regulator
MDVQLNDIALFVEVAKRKNFSHAAEALNIPAATLSRRVTELERRVGMQLLTRTTRRIELTEAGALYFERCRHIIEEARVAHEQLHDMAAQPKGRLRISLTASLAQLVLPLVMREFTEQYPDIECEFDVSGRPVDPISNPFDLVLRFGQQPDSSLISRQIMVMSHQLYASHDYLARHGEPLTPIDLSHHDCLRFPSGEGGSFWMLHSGERVVRVQVFGRLIANNMGMLARLAARGMGVVPLPVFHTMEKAIERIGLVRVLPDWHLTPMPLFALLPSRAIPAKTRAFLDFIQPRLNERR
>NZ_CP021110.1|WP_086058794.1|4067082_4067469_+|cupin-domain-containing-protein
MAASNPPWLIREADVPGYHPANHLGTTNRRLIGRENVGAANVEVVLGVIEKGKGALPHAHPGIEQVCYLIAGTARAEVDGVAADMGPGDCCYFPPDIPHVFTVTSEEPARLLVIYSPPYEERPDRVIR
>NZ_CP021110.1|WP_086058795.1|4067637_4068627_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MNRFARLSRHAAAAAAVLFAAAGLTGPGPARAAYPERPITLVVPFPAGSGTDAVGRIFAAELGRILNGQVVVENKPGGNATIAASYVARAKPDGYTLFVTTNTSHSAAPYLMKNVPYDPVKDFTPIARGGNLPFILVVNPKLPVKSVQELVAYAKAHPGKLTYASGNSTGIVAGATLARRAGIDIVHIPYKGTPQAITDVVGGQVDMMFTDVASGLPFVQSGKMRALAVSTAARSSVVPDIPSMEDAGIADFDINSWNGYFGPAGMPPEIVKTLNAAINKIVAEPEVRKQLAVLGFDAFSGTPEDFAAFVSQQLTLWGKLIRDAGIEQQ
>NZ_CP021110.1|WP_086058796.1|4068623_4069847_+|CoA-transferase
MKKTEHGAGGPLAGVRILDLTAVVMGPYATQVLADLGADVIKVESPAGDNMRAVGPMRNPGMGHLYLHLNRNKRSIVLDLKQPAARDACLALARDCDAVLYNIRPQAMARLGLDYAAFAASQPRIVYAGAYGYAEGGPYAGRPAYDDLIQGQTGIADLFRRQSQDEPRYAPLTLADRAVGLHTAIALLAAVLHARETGQGQSLEIPMFEGMAHMVLGDHLGGWTFDPPLGDTGYARLLAPHRKPYATRDGHVCLLIYNDKHWRNFFAAIGKPEMAADPRFATHTARAEHIGEVYAYVAQVMLTRDTDDWLRLLAEADIPASRLYGIEDLIRDPHLRATDFVRTVDHPTEGRLRTPAPLGRFDGTPTALRRPAPRLGEHSIEVLREAGFAESAIQALLDAQATHDGTR
>NZ_CP021110.1|WP_086058797.1|4069846_4071013_+|acyl-CoA/acyl-ACP-dehydrogenase
MDFTFTPDQIAMRDAVEQICARYPDEYWLERDRDGGFPHELHADLARDGWLGIAMPPDYGGAGLGMTEAALMMQTIAASGAGFAGASAVHMNIFGLNPVVVFGNAEQRARWLPDLIAGRHKACFAVTEPDAGLDTTRLTTRAVREGDHYVVHGRKIWISTAQVAHKMLLLARTTPLSEVDKPTHGLSLFYTDLDRERVEVREIEKMGRKAVDSNMLFIDGLCIPAADRIGEEGRGFEYILHGLNPERILIAAEAVGIGRAALNRAVRYANERKVFGRPIGQNQGVQHPLAQAWMQLEAADLMVFKAASMYDAGQPCGPYANSAKYLAAEAGHNACQTAVLTLGGMGYAKEYHVERLLRESYIPRIAPVSPQLILCFIAEKVLGLPKSY
>NZ_CP021110.1|WP_086058798.1|4071071_4071812_-|IclR-family-transcriptional-regulator
MSVKTALRVIEIIEVFAREKRPLALSELARLLEVPVSSCLALIRTLAELGYLYEVGRRNGYYPTSRLLAMAQQIARNDPVRDRVYPSLLELREATQETVVFAKLTPDHRVVYLEVLDSPHTIRYAPVAGEFRELHANSLGKALLSTLPPEKRQALLRRGPLTRFNERTMVDPDVVEADIAASRQRGWFRNLGESLAEVGAIAWPLALGGDHYAISVGAPVYRIEPNQEAYARILRAACAALEQNAI
>NZ_CP021110.1|WP_086058799.1|4071858_4072413_-|adenine-phosphoribosyltransferase
MQTDYAELVRRTIRSVPDWPKPGVTFRDITPVLQDPRTFRVLIDIFVYRYMRQRLDLVAGVDARGFIIGSVLAYELNLGFVPVRKQGKLPYRTVAESYSMEYANASVEMHADAVRPGQRVLLMDDLIATGGTMIAAIKLLQRLGANVVEAATIIDLPALGGSVAVAETGTPLYSVCRFDEEPAP
>NZ_CP021110.1|WP_086058800.1|4072447_4073452_-|LysR-family-transcriptional-regulator
MHGIALKYFAEVAAAGSLSAASQRLFVAVSAISRQIAKLEAEVGAPLFKRMSRGMVLSEAGELLLAHARRALLESEAVLQDIAGLKGAPSGTIRVVATDGPAHHFLPESMAAFRGRHAHVRFSLLVCTHAEAMRRVAEGQADLAVSFGAEQRKGTVVRYSVPAPVYAVMARAHPLARLASVAPMQLLPYPLASTESSSGTRKLLERCWRQEGMHFEPVFVSNLSAALMSFVRNSDRVMLGAYLPAMSALKRGGLVARPIDHPEMSTRRLQLHTMEGRLLPGVVEEFLEYIAAALPVPDQAAAPARRARTARRGAGAHPTPVQEGRIGLSAPARL

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Crispr_ID: NZ_CP021110_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021110_10

4133036-4133124

Orphan

Consensus_repeat	Method
CCGGTCCGCAGGCGCGCCCCCTTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021110_10

>merge|NZ_CP021110|10|4133036-4133124|CRISPRCasFinder
CCGGTCCGCAGGCGCGCCCCCTTGAGGGGGAAGCGCGCCAGCGCTTCGGGGTGGGCTTCCCTTCCGGTCCGCAGGCGCGCCCCCTTGAG

>NZ_CP021110|10|10|4133036-4133124|CRISPRCasFinder
CCGGTCCGCAGGCGCGCCCCCTTGAG	GGGGAAGCGCGCCAGCGCTTCGGGGTGGGCTTCCCTT
CCGGTCCGCAGGCGCGCCCCCTTGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021110.1\|WP_086058852.1\|4139240_4139957_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|235515
NZ_CP021110.1\|WP_086059617.1\|4137393_4138704_-\|murein-transglycosylase-A	unknown	unknown	gnl\|CDD\|377065
NZ_CP021110.1\|WP_086058838.1\|4123454_4124174_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP021110.1\|WP_086058839.1\|4124182_4125112_+\|ornithine-cyclodeaminase-family-protein	unknown	unknown	gnl\|CDD\|225280
NZ_CP021110.1\|WP_086058853.1\|4140081_4140789_+\|phosphoglycolate-phosphatase	unknown	unknown	gnl\|CDD\|237310
NZ_CP021110.1\|WP_086055842.1\|4133139_4134096_-\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP021110.1\|WP_086058849.1\|4135299_4136178_-\|DsbC-family-protein	unknown	unknown	gnl\|CDD\|239318
NZ_CP021110.1\|WP_086058855.1\|4142601_4143174_+\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|235552
NZ_CP021110.1\|WP_086059616.1\|4128796_4130308_+\|glucan-biosynthesis-protein-G	unknown	unknown	gnl\|CDD\|237328
NZ_CP021110.1\|WP_086058840.1\|4125205_4125496_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|238126
NZ_CP021110.1\|WP_086058841.1\|4125604_4125928_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021110.1\|WP_086058842.1\|4125924_4126227_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|223706
NZ_CP021110.1\|WP_086058846.1\|4128217_4128481_+\|DUF1488-family-protein	unknown	unknown	gnl\|CDD\|377825
NZ_CP021110.1\|WP_086058848.1\|4134299_4135253_-\|D-2-hydroxyacid-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|240646
NZ_CP021110.1\|WP_086058851.1\|4138769_4139144_-\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP021110.1\|WP_086058850.1\|4136227_4137397_-\|UbiH/UbiF-family-hydroxylase	unknown	unknown	gnl\|CDD\|181057
NZ_CP021110.1\|WP_086058854.1\|4141051_4142572_+\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184146
NZ_CP021110.1\|WP_086058847.1\|4130288_4132817_+\|glucans-biosynthesis-glucosyltransferase-MdoH	unknown	unknown	gnl\|CDD\|225494
NZ_CP021110.1\|WP_086058843.1\|4126242_4126974_-\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NZ_CP021110.1\|WP_086073271.1\|4127679_4128060_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236776

Protein	Function_ID	Function_description	E-value
NZ_CP021110.1\|WP_086058852.1\|4139240_4139957_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|235515	PRK05581, PRK05581, ribulose-phosphate 3-epimerase; Validated.	1.4947e-126
NZ_CP021110.1\|WP_086059617.1\|4137393_4138704_-\|murein-transglycosylase-A	gnl\|CDD\|377065	pfam03562, MltA, MltA specific insert domain. This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.	2.67398e-101
NZ_CP021110.1\|WP_086058838.1\|4123454_4124174_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.84674e-48
NZ_CP021110.1\|WP_086058839.1\|4124182_4125112_+\|ornithine-cyclodeaminase-family-protein	gnl\|CDD\|225280	COG2423, COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism].	7.61564e-63
NZ_CP021110.1\|WP_086058853.1\|4140081_4140789_+\|phosphoglycolate-phosphatase	gnl\|CDD\|237310	PRK13222, PRK13222, N-acetylmuramic acid 6-phosphate phosphatase MupP.	1.68885e-89
NZ_CP021110.1\|WP_086055842.1\|4133139_4134096_-\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.48556e-21
NZ_CP021110.1\|WP_086058849.1\|4135299_4136178_-\|DsbC-family-protein	gnl\|CDD\|239318	cd03020, DsbA_DsbC_DsbG, DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds formed by DsbA and prevent aggregation of incorrectly folded proteins. DsbC and DsbG are kept in their reduced state by the cytoplasmic membrane protein DsbD, which utilizes the TRX/TRX reductase system in the cytosol as a source of reducing equivalents. DsbG differ from DsbC in that it has a more limited substrate specificity, and it may preferentially act later in the folding process to catalyze disulfide rearrangements in folded or partially folded proteins. Also included in the alignment is the predicted protein TrbB, whose gene was sequenced from the enterohemorrhagic E. coli type IV pilus gene cluster, which is required for efficient plasmid transfer.	3.38366e-66
NZ_CP021110.1\|WP_086058855.1\|4142601_4143174_+\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	2.96572e-129
NZ_CP021110.1\|WP_086059616.1\|4128796_4130308_+\|glucan-biosynthesis-protein-G	gnl\|CDD\|237328	PRK13274, mdoG, glucan biosynthesis protein G; Provisional.	0
NZ_CP021110.1\|WP_086058840.1\|4125205_4125496_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|238126	cd00207, fer2, 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.	1.21638e-16
NZ_CP021110.1\|WP_086058842.1\|4125924_4126227_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|223706	COG0633, Fdx, Ferredoxin [Energy production and conversion].	4.49635e-12
NZ_CP021110.1\|WP_086058846.1\|4128217_4128481_+\|DUF1488-family-protein	gnl\|CDD\|377825	pfam07369, DUF1488, Protein of unknown function (DUF1488). This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.	1.70373e-05
NZ_CP021110.1\|WP_086058848.1\|4134299_4135253_-\|D-2-hydroxyacid-dehydrogenase-family-protein	gnl\|CDD\|240646	cd12169, PGDH_like_1, Putative D-3-Phosphoglycerate Dehydrogenases. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	1.30041e-167
NZ_CP021110.1\|WP_086058851.1\|4138769_4139144_-\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	1.36974e-80
NZ_CP021110.1\|WP_086058850.1\|4136227_4137397_-\|UbiH/UbiF-family-hydroxylase	gnl\|CDD\|181057	PRK07608, PRK07608, UbiH/UbiF family hydroxylase.	3.13983e-157
NZ_CP021110.1\|WP_086058854.1\|4141051_4142572_+\|anthranilate-synthase-component-I	gnl\|CDD\|184146	PRK13565, PRK13565, anthranilate synthase component I; Provisional.	0
NZ_CP021110.1\|WP_086058847.1\|4130288_4132817_+\|glucans-biosynthesis-glucosyltransferase-MdoH	gnl\|CDD\|225494	COG2943, MdoH, Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane].	0
NZ_CP021110.1\|WP_086058843.1\|4126242_4126974_-\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	2.54995e-36
NZ_CP021110.1\|WP_086073271.1\|4127679_4128060_+\|hypothetical-protein	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	0.00622986

>NZ_CP021110.1|WP_086058847.1|4130288_4132817_+|glucans-biosynthesis-glucosyltransferase-MdoH
MNLKPNNSVPGTDTVEDYLERLALPPQARQHALERAAQAAGEGQPALEAMHRALAGDDAAAAEPELASGLARLRAAEGDDPDIEAMARQLPDSGVCLSSAPPLNRTPMSPEPWITNPLVRGWRRLRGQAPSTAEDYNAIAPRMDPRWRLAGSRRRLVLLVMVALQTAVATYYMKGVLPYQGKQVLEIGILFLFALLFCWVSAGFWTAMMGFLQLLIGRDRYSISARGMSDAPLDPSARTAIVMPICNEDVPRVFAGLRATYESLAQTDALENFDIFVLSDSYKADICVAEQRAWVDLCKTVKGFGRIFYRRRRRRVKRKSGNIDDFCRRWGANYRYMVVLDADSVMTGDCLKRLVQLMEASPDAGIIQSAPQASGMDSLYARIQQFATRVYGPLFTAGMHYWQLGESHYWGHNAIIRLAPFMRHCVLAPLPGKGAFAGAILSHDFVEAALMRRAGWGVWIAYDLPGSYEELPPNLLEELQRDQRWCHGNLMNFRLFFIEGFHPVHRAVFLTGVMSYLSAPLWFLFLLLSTALLAVHTLTEPQYFIEPRQLFPIWPQWHPDKAIALFSTTAVLLFLPKVLGVLLVWARGARLFGGRQKVLSSMLQEVLFSMLLAPVRMLFHTRFVVAAFLGLSAKWISPARDNNETTWGDAFKRHGSQTLLGLCWAALVAWLNPVFLFWMAPILAALLLIIPLSVYSSRVDLGRRAYLSRLFRIPEETHPPTELQATRRYTAQNRSVPHIPDFEDAIVDPGVNALACAMATARHKPNPLNEAYRRQQVDHVMEYGVDALSEPQKIKLLDDPVSLGRVHGAIWRSREEHAVQLRERTAPREEAEPDLETAEAVL
>NZ_CP021110.1|WP_086059616.1|4128796_4130308_+|glucan-biosynthesis-protein-G
MGLGQSAQAFSFFDVMKQARDLAGQSYKAPEPNLPDSLQELKFAGYQQVRFKNDHLHWRNAGTKFTLSFYHEGMHFNTPVKINEIDAAGVHEIKFDPDDFDYGNLKLDPAALKNLGFAGFRVLYPVNSKDKKDDELASFLGASYFRVIGKGQTYGLSARGLAIDTALPSGEEFPRFREYWIARPAPEDSTLTIYALLDSPRATGAYRFILKPTDDSTVVDVKARIFLRDQVGRLGIAPITSMFLYGSNQPSPIPNYRPEMHDSDGLAIHTGNDEWLWRPLVNPRRLAVSAFSVENPRGFGLLQRGREFSRYEDLDDHYEKRPSLWIEPQGDWGKGSVQLVEIPTKDETNDNIVAFWVPEKQPAKGEPLDADYRMTWTLNENKTHTTPLAWVMQTRRSREEVKGPDLIRRADGSIAYIIDFVGPSLQSLPADATVTADTWVDGNGQIVENTVRPNGVTGGRRLILRVNVKDPTKPVEMRAFLTNGQTPLSETWTYRIPNEPEAK
>NZ_CP021110.1|WP_086058846.1|4128217_4128481_+|DUF1488-family-protein
MGNFANETHARVQDDAIFFTLTQNGETRQFEISGDALRECFGAEDSSGSALLRGFERGCEKIRSVAQAAFNTPTDGITTLGTGDFDG
>NZ_CP021110.1|WP_086073271.1|4127679_4128060_+|hypothetical-protein
MKLRRLTPALAFAAVFATGVATAQSSAPTTPSTTPNDTTATPPNNAKVPPGTASPAPNSTVTPQSNTGKGTATHKSGTSGHGSQHSGSMNKSRSDKSHSGSSSSSSTRSGNSAQPSESVPATGAGK
>NZ_CP021110.1|WP_086058843.1|4126242_4126974_-|iron-containing-redox-enzyme-family-protein
MAELMSRDEFRTALENAIKGKSANASPFSIAWASGKLSREHLCRWAENHYHYVGPFADYLGYLYARTPDHYTEAKDFLLANMYEEEIGGDRHTDLLIRFAEACGTTRERVTNPDNMSPTTRALQSWCYCVAMREDPIVAVAGLVVGLESQVPSIYRKQTPTLREKYGFTDEEVEFFDLHIVSDEIHGERGYQIVLEHANTPELQQRCLKICEIGAQMRLLYTTALYTDYVEKDIPLPELKMAA
>NZ_CP021110.1|WP_086058842.1|4125924_4126227_-|(2Fe-2S)-binding-protein
MPTVVFHKGGETYTDVVQDNANLVVRAGIKRFPYPHLRYECGMGKCAKCACRVIAGGEHLPPVNWKEKKQLGERVEQGYRLACQLWLTADIELAQDDEAS
>NZ_CP021110.1|WP_086058841.1|4125604_4125928_-|hypothetical-protein
MTTPTGPAFYAVLTSKPGIYHSEPGADVEIVETYDYVFCGKTKAVFQIVRAPGPTRVRIVEDAPPHTVNVVPTRVLERFATLEEARCAIGQLANFCTLDAALVRREG
>NZ_CP021110.1|WP_086058840.1|4125205_4125496_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MVEITFLTNGGKVVTAPPNSNLLRVSLKEKGGIPFKCGGGLCGTCKCLIEEGLENTDAVKPKERRHLTPEDFEKGYRMACQTFVNGNIKVSWEPGR
>NZ_CP021110.1|WP_086058839.1|4124182_4125112_+|ornithine-cyclodeaminase-family-protein
MLHISDEMVDAAVSASDAQNILLDAFRQFGQGQAAMQKRERTDSGGVKLSTLGAVIPGQDVVGAKVYTTIQGQFSFVILLFSARDGRPLATFDAAALTRRRTAACSVLAARALARPDAATLGLYGAGTQGAEHAAQMTAAFGLKQVLVHDPHAPRGYTDTLSARIGVPVVETDPQEIAAAADIVVTASRSTTPLFSGGALKNGAFVAAIGSSLPHTRELDDEALRRAARLVVEWKPQSLTEAGDIVLASGDALPPEKIVELAEVLSDKVVRQHADQIFIYKSVGVGLEDIAVAGLAYRRIAESRGLPQP
>NZ_CP021110.1|WP_086058838.1|4123454_4124174_+|GntR-family-transcriptional-regulator
MPTSNSSSTAARTPPPPASLKIGEQHPQLFAVVRDKLRERILSGEFTPGDRLVEGRLSDEMGVSRIPVREALRALAAEGLVTIEPRRGASVAVLSDAVAHDMIEVRATLEGLNAKLAAQRRDQSTVARLQAFLDEGNNAARADSLERFLALNSEFHEMLATIAGNVVLTDLMRSLRDRTALLFAPSNMRRAKQNWDEHAQILNAVIAGNGDLAALLASQHVHNAAKAYTEAQQSKPSST
>NZ_CP021110.1|WP_086055842.1|4133139_4134096_-|transposase
MSEATYVGIDVSSEVLEIAVSTQPSTWQASNDSGGIEQLAGQLQALRPALVVLEATGGYEFEAACVLQAQGLAVAVVNARMARDFARAMGALGKTDALDARMLATFARVLDQHPDRARFVKPLADAQLQRLQALVLRRRQIVQTMTSERHRLRISHEAARPSIERHLAFLRQELDDSDGHIAEHVQQHQAELARVLSSVPGIGAASVALLLAELPELGRLDRRRIAALVGVAPVNRDSGKMRGQRSIWGGRASVRCALYMASLSAVRYNPVLRAYYQRLLGTGKKKKVALVATMRKLLTILNAMVRHNKQWEPALDCP
>NZ_CP021110.1|WP_086058848.1|4134299_4135253_-|D-2-hydroxyacid-dehydrogenase-family-protein
MKIAILDDYHGVAADYADWASLGPQATVQVFREYLPDGPGRVAALQPFDVIVIMRERTPFPAELINALPALKLLVTTGLRNNAIDMEACKARGIVVSGAPGAPNAVNATAELSWALILALFKNLCTENQNMRQGQWQTGMPLPLKGKRLGVIGLGKLGSAVARVGRAFDMDVVAWSPNLTPERAEQGGARYAGKQELFATSDVVSVHLILSASTRHVVDAASIAAMKPTAFFVNTSRAGLVDQDALMDALRNGRLAGAGLDVFPAEPLPPDDPVRQLRNVVLTPHLGYVSEDNFKAFYANALEAIKAWAAGSPLRVL
>NZ_CP021110.1|WP_086058849.1|4135299_4136178_-|DsbC-family-protein
MTIRAWLSAACLAVAAASLAATSSAADKSVSTQSAGRPAAGETVTSTSGVAPAAKSTSTDGPNPGEKVVSTTQAAPTDADAVAARFHERFPDLNVTAVRRTPYGLFEVQVGMDLIYTDASVGWVMEGPLIDAVTRRDVTRERQEQIGSIAFSQLPLDLAIKRVNGDGSRVVAIFEDPNCGYCKQLRQTLEDVPNLTIYTFIYPILAPDSRVKARDIWCAPKPAQAWDDWMVRGKTPPTGSCNAPIDQVLALGQRLMVRGTPTLFFADGSRVSGALPRDELMTYLDKSSQKGG
>NZ_CP021110.1|WP_086058850.1|4136227_4137397_-|UbiH/UbiF-family-hydroxylase
MSEGIVVCGAGIVGLATALALARRRQPVSVLAPAAAVPAAPAAHYHPRVYALSPASQRFLAELGIWDALPAARMAPVDAMEVHGDADGAVTLTAWQAAQPHLAWIVEASEIERVLAQAVRLSGIPWITDRCVGYQRGMLLTEGGAQLRAGLAVGADGASSPLRSAAGLDHRSVPYDAVGLVTHLDADLPHHGTAMQWFRDDGVLALLPLPDTERGPQVSMVWSAPAAQARALQALPAEEQARQLSRHLAHITAGRLGEVRMNIGLHGFPLFVEHAQMVAPGVALAGDAAHRVHPLAGQGLNLGLGDAEALATIVAQREPYRGPGDLRVLRRYQRARAEPVLAMRLVTDGLHRLFASRGAPAAWLRNAGMRWVDAMPSIKRLLIEQASRG
>NZ_CP021110.1|WP_086059617.1|4137393_4138704_-|murein-transglycosylase-A
MSRLFPVALLLSMALAGCSTIAPDVPPEESPAAAPGAPQPSSAEAPLAVPPLTRLPDTPARPLAGRFQRVSYAEIPGWRDDDLTQFWPVFLRNCKGLMRPTSGNLTLPARAAPRAWQPVCAAAVDPARRPVATDPESVRRFLQTYLQPWRLLAADGKPAANLVTGYYEPLVRGSRRQGGLHQWPLYSPPDDLLTVDLGAIYPELAGKRVRGKLEGKRVVPYDTRAELENPGRRPPALVYIDDPVDNFFLQVQGSGRVLLTDGPDAGKTIRVAYADHNGQPYVSIGRWLIDKGELSADQASMQGIRAWAQRNPQRVREMLNANPAVVFFKEEPLVDPEAGPRGAYGVPLTPRRSVAVDASFVPLGTPVFLGTTWPGSDRALERLVFAQDTGTAIRGAARADFYWGTGDAAGQMAGRMKQRGQMWVLWPKQAGEPSAR
>NZ_CP021110.1|WP_086058851.1|4138769_4139144_-|Co2+/Mg2+-efflux-protein-ApaG
MKPYDLTVAVEPRYVPEQSDPAEQQYVFAYTVRITNTGEHPAQVISRHWIITDGNQRVQEVRGLGVVGQQPLLAPGETFEYTSGCPLPTPVGTMRGTYHCVGENGIPFEVPIAEFLLAMPRILH
>NZ_CP021110.1|WP_086058852.1|4139240_4139957_+|ribulose-phosphate-3-epimerase
MPPTMSFLSPVTRIAPSILSADFARLGEEVRNVVAAGADWIHFDVMDNHYVPNLTIGPMVCAAIRPHVDVPIDVHLMVEPVDELVPQFAKAGADIISFHPEATRHVDRTLSLIRDHGCMAGLVFNPATPLDYMDYVMDKLDVVLIMSVNPGFGGQSFLPSALTKLREARGRIDRWTQSGGQHIALEVDGGVKVDNIGEIRAAGADTFVAGSAIFGHPDYAAIIGAMRQQIAKATTLPA
>NZ_CP021110.1|WP_086058853.1|4140081_4140789_+|phosphoglycolate-phosphatase
MTSIKAALLDLDGTLLDSVPDLAMAANGMRLELGMGPLREDVIATFVGKGVDRLVQRALAGAQEHGELDPQLFARGRESFYRHYHLVNGDKAVVFDGVLEGLKAMRDMGLRLAVVTNKPTEFTLPLLQRTGLAGFFAAAVCGDTCARKKPDPQPVLHACTLLGVSPAQAVTIGDSLNDTQAGRDAGTRVLVVPYGYNEGVDVRTLEVDGIVSSLVEAAQWIARDGNVLPASAAHG
>NZ_CP021110.1|WP_086058854.1|4141051_4142572_+|anthranilate-synthase-component-I
MTELEFKALATQGYNRIPLIADTYADLDTPLGIYLKLAHSGPENGRMTCLLESVVGGERFGRYSFIGLPARTVIQARGTVTEVLHDGEVVETHHGDPLAFIEQYQSRFKVALRPGMPRFAGGLAGYFGYDTVRHIEPRLGPAVKPFPAGMEEGTPDIMLLHVDELVIVDNLAGRIYLVVYADPAQPEAYARAQQRLRELRQKLRKPVEIPYSHASMQTEERRDFKKEDYLAAVRRAKEYIAAGDLMQVQVGQVIAKPFRDSPLSLYRSLRSLNPSPYMYFWNFGDFHVVGSSPEILVRQERVVENGQPKSRITIRPLAGTRKRGATPEEDVALAAELQADPKEIAEHVMLIDLARNDVGRVAETGSVKVTDTMSIERYSHVMHLVSNVTGDLDPRMTSMDVLRAAFPAGTLTGAPKVRAMEIIDELEPVRRGIYGGAAGYLSYGGEMDVAIAIRTGVIKDGTLYVQAAAGIVADSNPEAEWAETEAKARAVLRAAEQVQNGLDQPI
>NZ_CP021110.1|WP_086058855.1|4142601_4143174_+|aminodeoxychorismate/anthranilate-synthase-component-II
MSLLMIDNYDSFTYNLVQYFGELGEDVRVARNDQITLEEIAAMKPDRICVSPGPCSPAEAGISVSVIREFGGKIPILGVCLGHQAIGAAFGGDIVRAPRIMHGKTVRIAHKGTDIFAGLPTPYTVIRYNSLTIDPGTLPDCLEATAVAEEDGDIMGVRHKTLPIYGVQFHPESVLSEHGHALMRNFLDIR

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP021110.1	1998421-1998452	1	0.969
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP021110.1	3390682-3390713	1	0.969
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP021110.1	3489759-3489790	1	0.969
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP021110.1	2561736-2561767	2	0.938
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP021110.1	602179-602210	2	0.938
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP021110.1	4352686-4352717	2	0.938

1. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to position: 1998421-1998452, mismatch: 1, identity: 0.969

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
cccccccgaagcgctgacgcgcttccccctca	Protospacer
****************.***************

2. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to position: 3390682-3390713, mismatch: 1, identity: 0.969

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
cccccccgaagcgctggcgcgcttccccccca	Protospacer
*****************************.**

3. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to position: 3489759-3489790, mismatch: 1, identity: 0.969

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
cccccccgaagcgctggcgcgcttccccccca	Protospacer
*****************************.**

4. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to position: 2561736-2561767, mismatch: 2, identity: 0.938

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
tcccccctccggtccgccagcgtcgccccctt	Protospacer
**.**** ************************

5. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to position: 602179-602210, mismatch: 2, identity: 0.938

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
cccccccgaagcgctgacgcgcttccccccca	Protospacer
****************.************.**

6. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to position: 4352686-4352717, mismatch: 2, identity: 0.938

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
ccaccccgaagcgctggcgcgcttccccttca	Protospacer
** *************************.***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021110_3	3.1\|1557935\|28\|NZ_CP021110\|CRISPRCasFinder	1557935-1557962	28	NC_010311	Streptomyces sp. HK1 plasmid pSHK1, complete sequence	67414-67441	7	0.75
NZ_CP021110_3	3.1\|1557935\|28\|NZ_CP021110\|CRISPRCasFinder	1557935-1557962	28	NZ_JX627582	Methylobacterium oryzae CBMB20 plasmid pMOC3, complete sequence	18475-18502	7	0.75
NZ_CP021110_3	3.1\|1557935\|28\|NZ_CP021110\|CRISPRCasFinder	1557935-1557962	28	ASHF01000034	Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence	117839-117866	7	0.75
NZ_CP021110_3	3.1\|1557935\|28\|NZ_CP021110\|CRISPRCasFinder	1557935-1557962	28	NZ_CP026489	Streptomyces sp. 604F plasmid unnamed, complete sequence	88265-88292	7	0.75
NZ_CP021110_3	3.1\|1557935\|28\|NZ_CP021110\|CRISPRCasFinder	1557935-1557962	28	NZ_CP009803	Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence	87527-87554	7	0.75
NZ_CP021110_3	3.1\|1557935\|28\|NZ_CP021110\|CRISPRCasFinder	1557935-1557962	28	NZ_CP029339	Streptomyces sp. SM17 plasmid pSM17A, complete sequence	104280-104307	7	0.75
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP021914	Sagittula sp. P11 plasmid unnamed1, complete sequence	31676-31707	7	0.781
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP025613	Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence	57748-57779	9	0.719
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP023072	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence	709972-710003	9	0.719
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	708133-708164	9	0.719
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NC_000914	Sinorhizobium fredii NGR234 plasmid pNGR234a, complete sequence	507119-507150	9	0.719
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP051544	Paracoccus sanguinis strain OM2164 plasmid pPspOM44, complete sequence	38839-38870	9	0.719
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP044425	Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence	330748-330779	9	0.719
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	AP019515	Halomonas sulfidaeris ATCC BAA-803 plasmid pBAA-803-A DNA, complete genome	214192-214223	10	0.688
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP026305	Streptomyces lunaelactis strain MM109 plasmid pSLUN1, complete sequence	117667-117698	10	0.688
NZ_CP021110_5	5.1\|2607561\|32\|NZ_CP021110\|CRISPRCasFinder	2607561-2607592	32	NZ_CP011053	Halomonas sp. KO116 plasmid unnamed1, complete sequence	264648-264679	10	0.688
NZ_CP021110_6	6.1\|3072759\|32\|NZ_CP021110\|CRISPRCasFinder	3072759-3072790	32	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1156214-1156245	10	0.688

1. spacer 3.1|1557935|28|NZ_CP021110|CRISPRCasFinder matches to NC_010311 (Streptomyces sp. HK1 plasmid pSHK1, complete sequence) position: , mismatch: 7, identity: 0.75

ccccgatcgtggggcgtctgttttcttc	CRISPR spacer
acccgatcgtgcggcgtctgttggccgg	Protospacer
 ********** **********  *.

2. spacer 3.1|1557935|28|NZ_CP021110|CRISPRCasFinder matches to NZ_JX627582 (Methylobacterium oryzae CBMB20 plasmid pMOC3, complete sequence) position: , mismatch: 7, identity: 0.75

ccccgatcgtggggcgtctgttttcttc	CRISPR spacer
ccccgatcgtggtgcgtctggttggggg	Protospacer
************ ******* **

3. spacer 3.1|1557935|28|NZ_CP021110|CRISPRCasFinder matches to ASHF01000034 (Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence) position: , mismatch: 7, identity: 0.75

ccccgatcgtggggcgtctgttttcttc	CRISPR spacer
acccgatcgtgcggcgtctgttggccgg	Protospacer
 ********** **********  *.

4. spacer 3.1|1557935|28|NZ_CP021110|CRISPRCasFinder matches to NZ_CP026489 (Streptomyces sp. 604F plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.75

ccccgatcgtggggcgtctgttttcttc	CRISPR spacer
acccgatcgtgcggcgtctgttggccgg	Protospacer
 ********** **********  *.

5. spacer 3.1|1557935|28|NZ_CP021110|CRISPRCasFinder matches to NZ_CP009803 (Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence) position: , mismatch: 7, identity: 0.75

ccccgatcgtggggcgtctgttttcttc	CRISPR spacer
acccgatcgtgcggcgtctgttggccgg	Protospacer
 ********** **********  *.

6. spacer 3.1|1557935|28|NZ_CP021110|CRISPRCasFinder matches to NZ_CP029339 (Streptomyces sp. SM17 plasmid pSM17A, complete sequence) position: , mismatch: 7, identity: 0.75

ccccgatcgtggggcgtctgttttcttc	CRISPR spacer
acccgatcgtgcggcgtctgttggccgg	Protospacer
 ********** **********  *.

7. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP021914 (Sagittula sp. P11 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
gcgcccagccggtccgccagcgacgccgcata	Protospacer
 * *** *************** **** * *

8. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP025613 (Niveispirillum cyanobacteriorum strain TH16 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
gccgacagccggtccgacagggtcgcccccga	Protospacer
 *.  * ********* *** *********

9. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP023072 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence) position: , mismatch: 9, identity: 0.719

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
aggccctgccggaccgccagcgtcgcggtctg	Protospacer
   ***.***** *************  .**

10. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 9, identity: 0.719

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
aggccctgccggaccgccagcgtcgcggtctg	Protospacer
   ***.***** *************  .**

11. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NC_000914 (Sinorhizobium fredii NGR234 plasmid pNGR234a, complete sequence) position: , mismatch: 9, identity: 0.719

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
aggccctgccggaccgccagcgtcgcggtctg	Protospacer
   ***.***** *************  .**

12. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP051544 (Paracoccus sanguinis strain OM2164 plasmid pPspOM44, complete sequence) position: , mismatch: 9, identity: 0.719

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
tgcccccgaggcggtggcgcgcttcctgatgc	Protospacer
. *******.*** ************.  *

13. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP044425 (Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence) position: , mismatch: 9, identity: 0.719

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
gctggccgaggcgcgggcgcgcttccccggcc	Protospacer
 *.  ****.**** *************  *

14. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to AP019515 (Halomonas sulfidaeris ATCC BAA-803 plasmid pBAA-803-A DNA, complete genome) position: , mismatch: 10, identity: 0.688

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
ggcatggacctgtccgccagcgtcgcgccctt	Protospacer
  . .  .** *************** *****

15. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP026305 (Streptomyces lunaelactis strain MM109 plasmid pSLUN1, complete sequence) position: , mismatch: 10, identity: 0.688

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
aggccccgccggtcctccagcgtggccggaag	Protospacer
   ************ ******* ***

16. spacer 5.1|2607561|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP011053 (Halomonas sp. KO116 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

tctccccgccggtccgccagcgtcgccccctt	CRISPR spacer
ggcatggacctgtccgccagcgtcgcgccctt	Protospacer
  . .  .** *************** *****

17. spacer 6.1|3072759|32|NZ_CP021110|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

cccccccgaagcgctggcgcgcttccccctca	CRISPR spacer
catccccgaggcgctggcgcgctaccaggcgg	Protospacer
* .******.************* **   . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1174311 : 1215129

Pseudomonas_phage(19.35%)

terminase,capsid,head,tail,portal,protease,integrase

attL 1174151:1174171|attR 1216064:1216084

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1174151:1174171	attL	NA	NA	NA	NA
WP_086059280.1\|1174311_1175295_+\|integrase	site-specific integrase	A0A2H4JE37	uncultured_Caudovirales_phage	4.6e-48	35.2
WP_086059281.1\|1175268_1175505_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_086056552.1\|1175809_1176142_-	hypothetical protein	NA	NA	NA	NA
WP_157664402.1\|1176128_1176299_-	hypothetical protein	NA	NA	NA	NA
WP_086056553.1\|1176291_1177146_-	hypothetical protein	NA	NA	NA	NA
WP_157664403.1\|1177142_1177322_-	hypothetical protein	NA	NA	NA	NA
WP_086056554.1\|1177318_1178233_-	hypothetical protein	NA	NA	NA	NA
WP_086056555.1\|1178237_1178507_-	hypothetical protein	NA	NA	NA	NA
WP_157664404.1\|1178503_1178734_-	hypothetical protein	NA	NA	NA	NA
WP_157664405.1\|1178730_1178985_-	hypothetical protein	NA	NA	NA	NA
WP_086059282.1\|1178968_1179478_-	DUF1643 domain-containing protein	A0A0U1W068	Pseudomonas_phage	4.0e-56	65.5
WP_157664406.1\|1179474_1179957_-	hypothetical protein	NA	NA	NA	NA
WP_086056559.1\|1179953_1180241_-	hypothetical protein	NA	NA	NA	NA
WP_157664407.1\|1180326_1180473_-	hypothetical protein	NA	NA	NA	NA
WP_086056560.1\|1180483_1180750_-	hypothetical protein	A0A2H5BHK6	Acinetobacter_phage	1.1e-15	44.2
WP_086056561.1\|1180758_1181367_-	YqaJ viral recombinase family protein	A0A0U2BXF3	Paracoccus_phage	1.7e-53	54.5
WP_086056562.1\|1181347_1182145_-	hypothetical protein	E5DV80	Deep-sea_thermophilic_phage	6.4e-16	33.2
WP_086056563.1\|1182287_1182560_-	hypothetical protein	NA	NA	NA	NA
WP_157664408.1\|1182549_1182711_-	hypothetical protein	NA	NA	NA	NA
WP_086056564.1\|1182707_1182980_-	hypothetical protein	NA	NA	NA	NA
WP_086056565.1\|1182976_1183891_-	DNA cytosine methyltransferase	A0A0F7L3T9	uncultured_marine_virus	4.3e-56	45.6
WP_086056566.1\|1183883_1184105_-	hypothetical protein	NA	NA	NA	NA
WP_086056567.1\|1184114_1184711_-	hypothetical protein	A0A0F6SIL9	Sinorhizobium_phage	2.6e-62	61.7
WP_157664409.1\|1184743_1184914_-	hypothetical protein	NA	NA	NA	NA
WP_086056568.1\|1185127_1186171_-	hypothetical protein	A0A0U4B0I3	Pseudomonas_phage	2.5e-28	48.9
WP_086056570.1\|1186968_1187205_+	Arc family DNA-binding protein	NA	NA	NA	NA
WP_157664410.1\|1187271_1187949_-	hypothetical protein	NA	NA	NA	NA
WP_086056572.1\|1188000_1188231_-	hypothetical protein	NA	NA	NA	NA
WP_086056574.1\|1188986_1189967_-	helix-turn-helix domain-containing protein	M9NZE3	Enterobacteria_phage	3.8e-10	33.3
WP_086056575.1\|1190049_1190310_+	hypothetical protein	D0UIL8	Aggregatibacter_phage	9.3e-09	50.0
WP_086056576.1\|1190402_1190846_+	hypothetical protein	Q3HQZ3	Burkholderia_phage	5.3e-28	46.3
WP_086056577.1\|1190845_1191259_+	hypothetical protein	F1C5C7	Cronobacter_phage	1.9e-19	46.2
WP_086059283.1\|1191258_1191600_+	DUF968 domain-containing protein	NA	NA	NA	NA
WP_157664411.1\|1191620_1192442_+	hypothetical protein	A0A2I7RQ47	Vibrio_phage	7.1e-10	38.6
WP_086056579.1\|1192438_1193827_+	replicative DNA helicase	A0A1B0VG30	Salmonella_phage	6.6e-93	42.3
WP_086056580.1\|1193829_1194240_+	hypothetical protein	NA	NA	NA	NA
WP_086056581.1\|1194275_1194575_+	DUF1064 domain-containing protein	Q3HQZ9	Burkholderia_phage	7.1e-37	69.7
WP_086056582.1\|1194726_1195302_+	hypothetical protein	NA	NA	NA	NA
WP_086056583.1\|1195332_1195665_+	hypothetical protein	NA	NA	NA	NA
WP_086056584.1\|1196110_1196395_+	HNH endonuclease	H2BDK0	Pseudomonas_virus	2.1e-22	64.0
WP_086059284.1\|1196403_1196982_+	hypothetical protein	A0A0F6WE48	Mycobacterium_phage	2.1e-08	35.6
WP_086056585.1\|1197018_1197465_+	hypothetical protein	A0A286S1P9	Klebsiella_phage	2.1e-40	60.0
WP_086056586.1\|1197443_1198967_+\|terminase	terminase	B5WZR8	Pseudomonas_phage	2.7e-225	79.2
WP_086056587.1\|1198972_1200262_+\|portal	phage portal protein	Q6JIM9	Burkholderia_virus	4.7e-117	50.1
WP_086056588.1\|1200251_1200938_+\|head,protease	HK97 family phage prohead protease	Q6JIM8	Burkholderia_virus	1.7e-70	64.0
WP_086056589.1\|1200949_1202191_+\|capsid	phage major capsid protein	Q6JIM7	Burkholderia_virus	1.5e-99	50.6
WP_086056590.1\|1202240_1202444_+	hypothetical protein	NA	NA	NA	NA
WP_086056591.1\|1202440_1202773_+\|head,tail	phage gp6-like head-tail connector protein	A0A0U4JX27	Pseudomonas_phage	3.6e-21	56.4
WP_086056592.1\|1202772_1203129_+\|head,tail	head-tail adaptor protein	Q9XJT0	Pseudomonas_phage	1.7e-32	55.8
WP_086056593.1\|1203125_1203614_+	hypothetical protein	NA	NA	NA	NA
WP_086056594.1\|1203613_1203976_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_086056595.1\|1204032_1204500_+	hypothetical protein	Q9MCA5	Pseudomonas_phage	4.7e-19	38.5
WP_157664412.1\|1204503_1204890_+	hypothetical protein	NA	NA	NA	NA
WP_086056597.1\|1204907_1205129_+	hypothetical protein	NA	NA	NA	NA
WP_086056598.1\|1205132_1207283_+	hypothetical protein	A0A0U2BXT9	Paracoccus_phage	2.5e-22	31.9
WP_086056599.1\|1207282_1207633_+	hypothetical protein	NA	NA	NA	NA
WP_086056600.1\|1207629_1208106_+	DUF1833 domain-containing protein	I7GYA2	Xanthomonas_virus	1.8e-10	30.1
WP_086056601.1\|1208139_1208520_+	hypothetical protein	NA	NA	NA	NA
WP_086056602.1\|1208690_1209074_+	hypothetical protein	NA	NA	NA	NA
WP_086059285.1\|1209079_1213006_+	hypothetical protein	Q52PQ3	Xanthomonas_phage	1.1e-49	26.4
WP_086056603.1\|1213606_1214152_+	DUF4376 domain-containing protein	NA	NA	NA	NA
WP_086056604.1\|1214193_1214460_+	hypothetical protein	A5A3W1	Burkholderia_phage	1.9e-09	40.7
WP_086056605.1\|1214456_1214717_+	hypothetical protein	I6NSG3	Burkholderia_phage	6.7e-15	46.2
WP_086056606.1\|1214703_1215129_+	glycoside hydrolase family protein	A0A223LHH7	Pseudoalteromonas_phage	1.2e-29	53.8
1216064:1216084	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1784769 : 1791742

Acinetobacter_phage(28.57%)

integrase

attL 1781435:1781450|attR 1790995:1791010

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1781435:1781450	attL	NA	NA	NA	NA
WP_086057042.1\|1784769_1785759_+\|integrase	site-specific integrase	A0A1B1P9F9	Acinetobacter_phage	1.3e-79	47.3
WP_086059344.1\|1785742_1785952_-	hypothetical protein	NA	NA	NA	NA
WP_086057044.1\|1786252_1786588_-	hypothetical protein	A0A2H4JCF4	uncultured_Caudovirales_phage	2.2e-10	59.6
WP_086057045.1\|1786584_1787187_-	hypothetical protein	NA	NA	NA	NA
WP_086057046.1\|1787191_1787662_-	class I SAM-dependent methyltransferase	A0A0N7IRF6	Acinetobacter_phage	2.3e-61	66.2
WP_086057047.1\|1787658_1787979_-	hypothetical protein	NA	NA	NA	NA
WP_086057048.1\|1787981_1788506_-	hypothetical protein	NA	NA	NA	NA
WP_086057049.1\|1788592_1789222_-	exonuclease	F8TUK8	EBPR_podovirus	1.6e-38	39.2
WP_086057050.1\|1789218_1789710_-	HNH endonuclease	Q2NPG0	Xanthomonas_virus	6.0e-33	48.4
WP_086057051.1\|1789709_1790651_-	recombinase RecT	E5AGD9	Erwinia_phage	1.5e-51	47.9
WP_086057052.1\|1790695_1791742_-	hypothetical protein	K7ZPX9	Xanthomonas_citri_phage	5.1e-13	36.6
1790995:1791010	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1804649 : 1829145

Burkholderia_phage(44.83%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_086057075.1\|1804649_1805312_+	hypothetical protein	G8C7P2	Escherichia_phage	8.4e-30	41.6
WP_086057076.1\|1805311_1805815_+	hypothetical protein	A0A142IF90	Pseudomonas_phage	1.1e-32	46.8
WP_086057077.1\|1805815_1807411_+	TerL protein	A9YWZ6	Burkholderia_phage	1.4e-251	77.9
WP_086057078.1\|1807419_1808871_+	DUF1073 domain-containing protein	A0A0P0I486	Acinetobacter_phage	9.5e-159	63.1
WP_086057079.1\|1808761_1809601_+	hypothetical protein	A9YWZ8	Burkholderia_phage	2.8e-62	51.6
WP_086057080.1\|1809597_1810086_+	HNH endonuclease	C4ML07	Xanthomonas_virus	8.7e-24	41.9
WP_086059347.1\|1810122_1811370_+	DUF2213 domain-containing protein	A0A0P0IRE1	Acinetobacter_phage	1.4e-73	44.9
WP_086057081.1\|1811386_1811872_+	hypothetical protein	A0A0P0I8F3	Acinetobacter_phage	3.2e-34	51.9
WP_086057082.1\|1811935_1812958_+	DUF2184 domain-containing protein	A0A0N7IRF2	Acinetobacter_phage	6.5e-130	68.5
WP_086057083.1\|1812968_1813328_+	hypothetical protein	NA	NA	NA	NA
WP_086057084.1\|1813337_1813721_+	DUF4054 domain-containing protein	A9YX25	Burkholderia_phage	1.7e-35	56.7
WP_086057085.1\|1813723_1814197_+	hypothetical protein	A9YX26	Burkholderia_phage	3.5e-38	55.2
WP_086057086.1\|1814205_1814586_+	hypothetical protein	A0A2H4J1A4	uncultured_Caudovirales_phage	3.5e-28	53.7
WP_086057087.1\|1814578_1815160_+	hypothetical protein	A9YX29	Burkholderia_phage	1.5e-46	52.4
WP_086057088.1\|1815224_1816706_+	DUF3383 domain-containing protein	A0A0P0I492	Acinetobacter_phage	7.4e-143	55.1
WP_086057089.1\|1816760_1817204_+	DUF3277 family protein	A0A2H4J619	uncultured_Caudovirales_phage	1.2e-43	58.9
WP_086057090.1\|1817203_1817602_+	hypothetical protein	A0A0N7IRF3	Acinetobacter_phage	3.1e-11	34.6
WP_086057091.1\|1817613_1817814_+	hypothetical protein	NA	NA	NA	NA
WP_086057092.1\|1817797_1819639_+	hypothetical protein	A0A0M4REK7	Salmonella_phage	5.9e-81	44.6
WP_086057093.1\|1819635_1820208_+	hypothetical protein	A0A0M3ULD5	Salmonella_phage	1.3e-31	39.9
WP_086057094.1\|1820204_1820513_+	hypothetical protein	A0A0M4R5B7	Salmonella_phage	7.7e-18	43.0
WP_086057095.1\|1820516_1821440_+	hypothetical protein	A9YX04	Burkholderia_phage	7.1e-67	50.6
WP_086057096.1\|1821432_1822179_+	hypothetical protein	A9YX06	Burkholderia_phage	3.2e-78	59.9
WP_086057097.1\|1822187_1822664_+	hypothetical protein	A0A220GJG3	Streptococcus_phage	3.7e-19	40.4
WP_086057098.1\|1822668_1823022_+	hypothetical protein	A9YX11	Burkholderia_phage	1.1e-31	60.7
WP_086057099.1\|1823018_1824200_+	hypothetical protein	A9YX12	Burkholderia_phage	4.9e-137	68.8
WP_086057100.1\|1824201_1824870_+	DUF2612 domain-containing protein	A9YX13	Burkholderia_phage	9.3e-77	65.0
WP_157664432.1\|1824881_1826048_+	hypothetical protein	A9YX14	Burkholderia_phage	1.0e-17	38.0
WP_157664433.1\|1826040_1826442_+	hypothetical protein	NA	NA	NA	NA
WP_086057103.1\|1826497_1826764_+	hypothetical protein	A5A3W1	Burkholderia_phage	5.1e-10	43.2
WP_086057104.1\|1826760_1827021_+	hypothetical protein	NA	NA	NA	NA
WP_086057105.1\|1827007_1827433_+	glycoside hydrolase family protein	A0A1J0GVQ7	Pseudoalteromonas_phage	1.1e-30	53.8
WP_157664434.1\|1827429_1827813_+	hypothetical protein	NA	NA	NA	NA
WP_086057107.1\|1828243_1828459_-	hypothetical protein	NA	NA	NA	NA
WP_086057108.1\|1828461_1829145_-	DUF159 family protein	C7BGE4	Burkholderia_phage	1.7e-33	40.6

DBSCAN-SWA_4

4306906 : 4315321

Enterobacteria_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_086058988.1\|4306906_4307647_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	2.6e-11	26.4
WP_086058989.1\|4307652_4308453_-	ABC transporter permease	NA	NA	NA	NA
WP_086058990.1\|4308515_4308854_-	EamA family transporter	NA	NA	NA	NA
WP_086058991.1\|4308850_4309858_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_086058992.1\|4309880_4311902_-	glycosyltransferase	A0A1V0SAH6	Catovirus	2.1e-07	38.3
WP_086058993.1\|4311904_4312462_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.4e-49	51.9
WP_086058994.1\|4312458_4313349_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.0e-98	61.3
WP_086058995.1\|4313357_4314254_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.4e-22	31.1
WP_086058996.1\|4314250_4315321_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	9.0e-90	49.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021110

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection