CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021122	Mycobacteroides abscessus subsp. massiliense strain FLAC047 chromosome, complete genome	4 crisprs	DEDDh,c2c9_V-U4,csa3,cas3,DinG,cas4,WYL	0	2	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021122_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021122_1

417012-417109

Orphan

Consensus_repeat	Method
GTGGCGCGGCTCCTGGGGTCTGGGTTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021122_1

>merge|NZ_CP021122|1|417012-417109|CRISPRCasFinder
GTGGCGCGGCTCCTGGGGTCTGGGTTCCGCAGCCTGGTGGACTACCCGGACGGTGGGCGCAGCGCCCTAGTGGCGCGGCTCCTGGGGTCTGGGGTCCG

>NZ_CP021122|1|1|417012-417109|CRISPRCasFinder
GTGGCGCGGCTCCTGGGGTCTGGGTTCCG	CAGCCTGGTGGACTACCCGGACGGTGGGCGCAGCGCCCTA
GTGGCGCGGCTCCTGGGGTCTGGGGTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021122.1\|WP_079640362.1\|412961_414974_+\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|280533
NZ_CP021122.1\|WP_131831764.1\|422800_423334_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209228.1\|423335_425000_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209219.1\|414960_415962_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366631
NZ_CP021122.1\|WP_065209223.1\|420270_420831_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235561
NZ_CP021122.1\|WP_065209213.1\|410522_410912_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209229.1\|425088_426246_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209212.1\|410150_410486_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209216.1\|411768_412662_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209226.1\|422568_422808_+\|AraC-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP021122.1\|WP_131831763.1\|426736_427006_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209217.1\|412661_412913_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NZ_CP021122.1\|WP_065209221.1\|418376_419939_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209214.1\|410949_411198_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274575
NZ_CP021122.1\|WP_005065402.1\|408894_409479_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209222.1\|419935_420211_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_005065400.1\|408030_408747_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP021122.1\|WP_065209225.1\|422300_422576_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209215.1\|411444_411687_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|185640
NZ_CP021122.1\|WP_065209220.1\|418053_418314_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021122.1\|WP_079640362.1\|412961_414974_+\|N-6-DNA-methylase	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	4.15681e-20
NZ_CP021122.1\|WP_065209223.1\|420270_420831_+\|hypothetical-protein	gnl\|CDD\|235561	PRK05686, fliG, flagellar motor switch protein G; Validated.	0.00123579
NZ_CP021122.1\|WP_065209217.1\|412661_412913_+\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	4.91709e-29
NZ_CP021122.1\|WP_065209219.1\|414960_415962_+\|hypothetical-protein	gnl\|CDD\|366631	pfam01420, Methylase_S, Type I restriction modification DNA specificity domain. This domain is also known as the target recognition domain (TRD). Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity subunit (this family), two modification (M) subunits and two restriction (R) subunits.	6.38032e-12
NZ_CP021122.1\|WP_065209214.1\|410949_411198_+\|hypothetical-protein	gnl\|CDD\|274575	TIGR03429, Tryptophan_dimethylallyltransferase_2, aromatic prenyltransferase, DMATS type. Members of this protein family are mostly fungal enzymes of secondary metabolite production. Characterized or partially characterized members include several examples of dimethylallyltryptophan synthase, a brevianamide F prenyltransferase, LtxC from lyngbyatoxin biosynthesis, and a probable dimethylallyl tyrosine synthase.	0.00541985
NZ_CP021122.1\|WP_005065400.1\|408030_408747_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.26986e-05
NZ_CP021122.1\|WP_065209215.1\|411444_411687_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|185640	PTZ00461, PTZ00461, isovaleryl-CoA dehydrogenase; Provisional.	0.00421892

>NZ_CP021122.1|WP_065209219.1|414960_415962_+|hypothetical-protein
MPTIEDVFHVEYGNQLDMNKQIPDPNGVCFVGRKGNNQGISGRVREIPGVKKYPAGALTVALGGSRLLATFVQQEPFYTAQNVAVLTPRDANMPLSERLFYAMAITANRYRYTAFGREANRTIRTIELPAKVPSWVSSAVVESLSHMEDSADDPIELTPPETWGTYRVDELFTVHKGDYVKGSGKTVGNIPRITSTASNNGQSGLCGMTPNAEAGSISVARNGSVGEAFYQPTRYFATDDVHVFTPLPEVGPITAGAALFVCTIIRLEKYRYNYGRKWSLDKMRATEIRLPQREDGTPDWDYMTRYVHGLPFSSVLADEPGNSEDETEPAQRG
>NZ_CP021122.1|WP_079640362.1|412961_414974_+|N-6-DNA-methylase
MVGVSYRRSGWVDKVRPANCVTGVIHEGWLVANERNNEKLVRDKLVELGYYESEDLTVEEQQSKNATIKRLLRAASKSGSGNVGYPEFIVTSIEDDDVVLIIECKAAKNRHASKGLDKPVEFAVDGALHYARALSKEFHVVAVGSSGESERDWKVSTYLHAKGTDVPIPLTARSGVAIDRIVSWDDYRDAFTYDPEVKRKRIEDLLAVSRAMHNFMRDYARLTESEKPLLVSGTLIALMNKPFRTSYSTYKADRLQSAWLNAIKEQIEEAEIPRAKKNNITQPYSSIAVHPELGRSTEKFPKGPLHELIRILDTEVMPLMDVYHDYDVVGQFYGEFLKYTGGDKKSLGIVLTPRHITDLFSRLAQVSKDDVVVDICAGTGGFLIAAMARMLEQCVTEDERLDVKRNRLIGVEDQPNMYTLAASNMILRGDGKANLYQGSCFEKPILDAIKKHRRNTREKAGTLRPNIGLLNPPYSQKGEGLNELDFVMTMLDVLAPGGLGFAIVPVSCATGTYGKHELLKYHRLEAVMSMPPELFSPVGVVTCVMVFRAHTPHANTPDFKTWFGYWREDGFIKTKHMGRIDAGGWEDIRDHWVDTFVNRTVKVGESVLHRVGPEDEWTAEAYMQTDYSVLTQADFEKVVRDYAIYKATRNHGGVEESESEDDEETDDADD
>NZ_CP021122.1|WP_065209217.1|412661_412913_+|glutaredoxin-family-protein
MLGHGKQQVIVYTKPLCPQCEQTKKWLDGRGIAYETRDVTADEGAREEALALGYLGAPVVVADGEHWSGFRLDRLKALATDAA
>NZ_CP021122.1|WP_065209216.1|411768_412662_+|hypothetical-protein
MVSASTPIPAAHNSTSGGRDTKITKRLADALRKREMMVMAGAPAASIAAIETRIARLGGAHLIADQPETTAATVHPITDAPSAAKGEDRAQEDGLEAIRRLTAARIAVIEAKRARIAALRAALEAAEADLDATLDAAWRSPLGEGIAPLMSAVPDTDPVQPAEPAVEPDTADDVETSTSPAADDEGNPWAGLAERAAAERADAEAVEVLGEAFAAYEPAHVLAVARGGSARWVRGPGGEWLVAVRETLTLEGRWAEIERRDGTTSVERLSRAVAVGTVQGVVVAVCEVEPDDTAGVA
>NZ_CP021122.1|WP_065209215.1|411444_411687_+|helix-turn-helix-domain-containing-protein
MSRTPKDIEVTPELRRLITTARKAVRVANRAQEQLKEAAHQRQHAIAALTEHGMSARQIAEQVGVTEAAVYLTRSRTRKP
>NZ_CP021122.1|WP_065209214.1|410949_411198_+|hypothetical-protein
MGAYRIEIVPDRQKLRVLDGDSGALSPGAAVVVLNDVTDYQASAIARRVATYLAKIGWAIPAEGFGDTVEKIAADVKAKTGG
>NZ_CP021122.1|WP_065209213.1|410522_410912_+|hypothetical-protein
MTDDLNTLLDNIDALEADDRGADSDAPYPWTDAATWRADGGHQEPDDEPIIPWDIPGRVIMLTAHLGDGRAASWSMLTGWSGDPCVVRAAQAVAALYSELGEMCAAARGLIGVAVDGWVSEAVWAAARL
>NZ_CP021122.1|WP_065209212.1|410150_410486_+|hypothetical-protein
MRSLDDLIADIDQLEADDELRPLPGESEAEFKARMLSEFDELNAAEDTGALTIAPWDAWRWTPAAEPEPTPAAAPTYLIDPEDIHTIMPRGGPLTVSIGGRRLGTLNPAAA
>NZ_CP021122.1|WP_005065402.1|408894_409479_-|hypothetical-protein
MKKRLVSAGVIALAAALSGPALAAAAPADEQQIRDIVAGEAAAIKSLDNAKLSTFFCDKFRGVVASKTADDQIPPLSQVAGYGPQMISAVASAAGVSGPTTQALTTAIQNNDDKAYRSSFHNAAREVLSGVTYNVSDVNVTAPTATADVTAQGHDVTANQQREFVQENGKWKDCTDPEKRAQTSGNPLLTSLLN
>NZ_CP021122.1|WP_005065400.1|408030_408747_-|GNAT-family-N-acetyltransferase
MPNFSPIITDFWSTYFGRGTVLQDGDDFQLTVYPDLDEDAQLMVLHTADGKTKVSLVPELAERAGFDGAQPISAESFWNSLDAAGMTMHGADSLFYFTEEARAALVAEPPTGDIRQLTADDGAIFKAFESAATEEDLDDAQVELDHWAVFGSFDNGRLVGVASMYQWEDAPIMDLGVLVLPIFRGRGHARGLVRAAFRYACTRGYEPQYRCQLDNAASSALAPVAGLTLFGTLDVITS
>NZ_CP021122.1|WP_065209220.1|418053_418314_+|hypothetical-protein
MAICMDEVASLLPADTPSEVSVQWIAETFGVTEATVKYAIQVGKLPARRIPDRTGGTAAWRVRPEHALLIWGHRLLTRNIHASNQG
>NZ_CP021122.1|WP_065209221.1|418376_419939_+|hypothetical-protein
MTLPNNVNFNADNPFGDVIGRDWLTDLEQSTDFWNRSPQLQYIAWAAAQEKVSPWGLLMLAQLHRLSHIKPTVVLVKRDGSPGQTLFSGTSLNMFGCLTADSGGGKSVTFKLSSEIIPPSHTPISDGTGQGLVKSIAETEKVTSEDGQKLAEPYYITRFNRHSLVVHAPEIKTLNAEFARENSKTDSMMRSMWSGETVGMTTGDRDRRVTLPPNMYRIVGAWGVQAVNAWAILAGVDDGTPQRFLWMPGEEFRRGITRTNPGQVTFPEPVFGQVGSNPFGVSGGELPTEYKDGDPLPAPIWVTWSPQMRTDIAALQAQREALRDREPYADLTPEQVAAEEAVIMQSHSNLTRIKLAAMFAFLHGRPNPTDEDWELAGYQLQVSTRELAGVWKKVQGKADAERRKRAEDRGVEMHIARATADEKDAQEQSAFTHEVWQHICQSGPFDNRQLRKWAGGDNRKKMLTKALRALVDDERVMLDGGNRYWGVWVSPDGRTTYCPAEKVGQFIPLVPRSTTQGGAA
>NZ_CP021122.1|WP_065209222.1|419935_420211_+|hypothetical-protein
MTEQPDRYALRYTRKRVLEEVYLEPYVSTRESLIRHTGHTPERVDTAIQALIAEGVIYEDGEGGISLTSSGEKERRVWIREWRRKRRQRRA
>NZ_CP021122.1|WP_065209223.1|420270_420831_+|hypothetical-protein
MPNTTDYTLIPLNPPLVVSGRVEVVREDEQPFDFENGLAVALAEMLDSDGTHYDYSVVMPNGRVYEVGCYLITSAEPWTPNARPANNIAAPSGGSTPAPSAFSTEVWNELSSNGPMSIKEIRAWAGGDARRRMVTVALRDLQDRGLIVIDGGGRYWATHKGQLLPFVRSAEFTPSTDGDIAREINA
>NZ_CP021122.1|WP_065209225.1|422300_422576_+|hypothetical-protein
MSLSTVIARFLEDTLDQESGSVAEELSVPATADLFGVSNSAIYHAIKVGKLAAAPVLTADGSVAGYRIPLHGAFAVWGHRLLNTKKDAADA
>NZ_CP021122.1|WP_065209226.1|422568_422808_+|AraC-family-transcriptional-regulator
MRDTERAERLAVVADQLTTLRAERLAVVADQLTTLRAERDELIRALRDHGWTLERIAQHAGITAQAIHKVLKKENTNHD
>NZ_CP021122.1|WP_131831764.1|422800_423334_+|hypothetical-protein
MTDPRVGVRSMNGIPIVELPDHRGFDTADELADAILAQINSGSLPPATKEQTARATAAAVLQQLFMRKHGKRMLALRGRIQSGDAPQSRQNIDNAAEKLRKNTAALDRPTIGEVIDSGVSAAVNGQSKVLKGSSGEGDDWMAGLGFEELEQLVYAKFGDEGHPIRRLWRGLIEKLDG
>NZ_CP021122.1|WP_065209228.1|423335_425000_+|hypothetical-protein
MPAPIRNLDLKVLSRLWFTGSITEVDLHKRFGIRANDPVIQALRADRRIEPTRTPRIRPCVHVPKTVPHAQTGEPVVIEDALTPEALEAVRFTLATLRITDTVSYNDVIARFGAGHAALAKDALLSDDLITVSGEALTARTIYAIDTDEAQAYLATVNQSAPAADTQPIAPKTVPTAPAADPNAFPTERLNALGDDAWEKGVYQLIADTDRRGGYPVGDTPKPATQALLDSGWARRNPDTPSLVEFRSPKHDDELRRELGDEGFRRVVQATAAVVMLLSERADSLDILRAIYGDRAVDLATVRLSGAVIKREDKGWSLLPKGQRPAYFTAQEKAKLREQIDEAKRRKEAERQREEADRRTAAFEKRRAEDPAFAELADRVTSVDQKLDVVSRNSRESRDGVGAIYESVKKIEENVSTGAQKTGRVYAQPTDHDVAVRILEILLVEGHKTRNHFTSRRFKGPRQPLVGPALDLLVESGAVRKVSSLYMLVDPTKFGYTAEELRERYEATKRTYASRTAKARERAARAVDSVRDSQFVASVKSRIGGSSMLEALDA
>NZ_CP021122.1|WP_065209229.1|425088_426246_+|hypothetical-protein
MNPIQSTMASIRSAFSRGDTDPDVVSENLVFYWVWFWTFTGVSVFVNAVHAWIKAPLFFSLLRTTDPETPKQTHILWEAWKTADDAPPVWFVALAVFLGALMPVALAFGSHALAHPRPGVSRAREVGTYVLTGATVVGAFVLSFLAMQDMAMMFLGLTPMQAAILPIAVDIAIVSSLWEIVSRSPKVHTSAAQQKISEAVAEFNAARETDNAALLERVETTLDTVQERFDTSLAAFHDTILGQVRDELGTALETVQERLETFREMVQNQTTPSRPSVSSRPVSRVSGGSSQPERLITAPETLAAELVNRGALTQPQDIIEMVLTASLDGSSTQKIADAVTAQLPSGKSISKSTAHRIMSVARDLDAELVAAEMESETESEPAMAS
>NZ_CP021122.1|WP_131831763.1|426736_427006_+|hypothetical-protein
MTDIREAVDAGVTATEAFGARRGGLVGVWLDDPDRPGVSAFVNQGRLTRLVIPQAYMGMRREELEAVINAVIINAHLDASPAIRARSAA

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Crispr_ID: NZ_CP021122_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021122_2

436584-436789

TypeV-U4

Consensus_repeat	Method
GCCGTCACCCCCGCGCCCGTGGAACGGAC	PILER-CR
GCCGTCATCCCCGCGCCCGTGGA	CRISPRCasFinder

3 spacers

c2c9_V-U4

The CRISPR arrays of NZ_CP021122_2

>merge|NZ_CP021122|2|436584-436789|PILER-CR,CRISPRCasFinder
GCCGTCATCCCCGCGCCCGTGGAACGGACCTGTGGACCGGTGAGGAGCTGACTGAGCACTTGCCGTCATCCCCGCGCCCGTGCAGATGCGACATGTCTGTCACCAGAACGATGCCGTCACCCCCGCGCCCGTGGAACGGACATTTTGTCCGGGTCGAAACGAACCCCAGGTCTCCTTGCCGTCACCCCCGCGCCCGTGGACCGGAC

>NZ_CP021122|2|1|436584-436789|PILER-CR
GCCGTCATCCCCGCGCCCGTGGAACGGAC	CTGTGGACCGGTGAGGAGCTGACTGAGCACTT
GCCGTCATCCCCGCGCCCGTGCAGATGCG	ACATGTCTGTCACCAGAACGATGCCGTCAC
CCCCGCGCCCGTGGAACGGACATTTTGTC	CGGGTCGAAACGAACCCCAGGTCTCCTTGCCGTCAC
CCCCGCGCCCGTGGACCGGAC

>NZ_CP021122|2|2|436584-436783|CRISPRCasFinder
GCCGTCATCCCCGCGCCCGTGGA	ACGGACCTGTGGACCGGTGAGGAGCTGACTGAGCACTT
GCCGTCATCCCCGCGCCCGTGCA	GATGCGACATGTCTGTCACCAGAACGAT
GCCGTCACCCCCGCGCCCGTGGA	ACGGACATTTTGTCCGGGTCGAAACGAACCCCAGGTCTCCTT
GCCGTCACCCCCGCGCCCGTGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021122.1\|WP_065209246.1\|441055_441385_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_079673336.1\|428620_429286_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209247.1\|441410_441908_-\|DUF732-domain-containing-protein	unknown	unknown	gnl\|CDD\|377566
NZ_CP021122.1\|WP_065209239.1\|436199_436577_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209236.1\|432121_432469_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_131831762.1\|439203_439938_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209232.1\|427240_428590_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP021122.1\|WP_065209245.1\|440508_440982_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP021122.1\|WP_131831763.1\|426736_427006_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209237.1\|432500_434780_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367841
NZ_CP021122.1\|WP_065209244.1\|439969_440248_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209242.1\|438646_439033_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224514
NZ_CP021122.1\|WP_065209238.1\|434815_436114_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226365
NZ_CP021122.1\|WP_065209240.1\|436810_438235_-\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NZ_CP021122.1\|WP_065209241.1\|438231_438459_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP021122.1\|WP_065209248.1\|441904_442852_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209231.1\|427002_427251_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_065209249.1\|442848_443487_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|379158
NZ_CP021122.1\|WP_065209234.1\|429445_431593_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP021122.1\|WP_065209235.1\|431866_432118_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379402

Protein	Function_ID	Function_description	E-value
NZ_CP021122.1\|WP_065209249.1\|442848_443487_-\|HNH-endonuclease	gnl\|CDD\|379158	pfam13392, HNH_3, HNH endonuclease. This is a zinc-binding loop of Fold group 7 as found in endo-deoxy-ribonucleases and HNH nucleases.	1.00064e-07
NZ_CP021122.1\|WP_065209247.1\|441410_441908_-\|DUF732-domain-containing-protein	gnl\|CDD\|377566	pfam05901, Excalibur, Excalibur calcium-binding domain. Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.	2.72134e-17
NZ_CP021122.1\|WP_065209237.1\|432500_434780_+\|hypothetical-protein	gnl\|CDD\|367841	pfam04147, Nop14, Nop14-like family. Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.	0.00016111
NZ_CP021122.1\|WP_065209242.1\|438646_439033_-\|hypothetical-protein	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	0.00509293
NZ_CP021122.1\|WP_065209238.1\|434815_436114_+\|hypothetical-protein	gnl\|CDD\|226365	COG3846, TrbL, Type IV secretory pathway, TrbL components [Intracellular trafficking and secretion].	0.000113995
NZ_CP021122.1\|WP_065209240.1\|436810_438235_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.92104e-30
NZ_CP021122.1\|WP_065209241.1\|438231_438459_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.00586068
NZ_CP021122.1\|WP_065209245.1\|440508_440982_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.82072e-11
NZ_CP021122.1\|WP_065209232.1\|427240_428590_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	0.00100542
NZ_CP021122.1\|WP_065209234.1\|429445_431593_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.14869e-07
NZ_CP021122.1\|WP_065209235.1\|431866_432118_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379402	pfam13936, HTH_38, Helix-turn-helix domain. This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	0.000710136

>NZ_CP021122.1|WP_065209239.1|436199_436577_+|hypothetical-protein
MRFTHADGREVTVEVLIPGEEVTTELVLDTEWASKSLKVSGDTQLASRVGAALLDGERVQIGEPWVYVHISPYRPDYAAIAAAICVGLTPDMSTLTDEQRHMVAGMDMDARHRAVTERPGRRICF
>NZ_CP021122.1|WP_065209238.1|434815_436114_+|hypothetical-protein
MVELPWDDAKTRFEELAKKFDSFALTFNEGAKGALADAMEDRVKAVNEFTSAVAMAIMDRPAASAAAQHAADEVLRDAPKPAEVRKAEVEAAFMTLRAKQSIIPLPQAAAYEQKAQELRSRREEAYEFHTDASSVNAPNFIASPPPMPELANNSRGVDGGGHGNSGTGYPGGNGGQGASGGGPGAGAPGSGSVTGGSGSGGGLGGGSVGDSEIGTETSSDGLGAGAGGMQQPMMGQQPMQGQPQAGAAGANPAAFGQQPGMLGSTSPSAADAMRRNRDRKRDRDRDIATGLTGAAGGAAAVMGGAAASGVDRGVSVAGVNTKADTSGLGTNLSGANGPKPGEGGRGGAGGGMMRGGMMGGMPMGSGAQGGAGGTKEKPDIKPGVKDAALHGYEPLKDAIPGGVIGSETAEPEDETGVDRFFDKEDWDRKSRS
>NZ_CP021122.1|WP_065209237.1|432500_434780_+|hypothetical-protein
MAYYETHPIVDGEVLDSKVVTDDGDGKRDASSARRDGDSGNKDGNKGGGKGGGKGGVGRNLLNAVVPATALASRKTWDVSKRAATAVSNKLRDPKFLVKRVLPGGMVLAGIEIFDAIRSADPIIHNPPAEGRTRYLPVAGNGDIDSPHGDPNATVEALDAQIDKVNQDTWGFDPDKIWSYCDAGNCGEGCIEIEVGPLEFDEEGAVTPMLRWSDIVDEIYGTLSQYAGEMWADRLLQKYGTNGIAELESLVTRTEDVATALVAAVKASEEMGVGSYQALRHMVRAGREEMQGRLDDENSTYGWVGDALFGGRGEGSLERLKEAGKKVSAAQQSNDEAIAKLNEALDAWDAKIAGTEDNTTSTPPVPFEQSNNSRGVVDDDEPMTPLPGSPGGVGSVDGGPTADPLDNDEKTDPFMDSLADKLGNLGTPESPFASSPLGAGGGGLPDMGSGAPLSGGATNPFESADSPLSDNAENPFEDDEDDVLDEGEGGIEEESDDDTLDEGEGGFEDEDLDDIVEKTDDAADGVVEDTPAEGEDAPVTAEASVAPAAAVNTDPNSPEARTVTLPDGRQIEFPDAKTAEMVRALVAADPSAPTSIYTAADQAGFPVPPMGQPIGDMVPPSSIRPGDLVMGAAGSGVFIGNGEVLMENQEVKPLADVTQFTEPNQGVYRLDNPDAPAGTDPSTAAAQPVSADGTAAPVTGDTSPVGGGSQPDGMSTTTGTPGQPDTVPAGETVTPDADQGGGLGDTTEEESLDPNAAAF
>NZ_CP021122.1|WP_065209236.1|432121_432469_+|hypothetical-protein
MPQNQTEIQLDDEVLAAVTSTLKNFAERLDAASKQAVHELEEMMLEPLKQQTGSIPPVYQDLADALTTTVRRMESINRKLTGMLRTDAATIDNQVQVQGENQTMHARRVDAIDTL
>NZ_CP021122.1|WP_065209235.1|431866_432118_+|helix-turn-helix-domain-containing-protein
MSDHAANVLESVGDFEARIIAERFRRCTERVEEARKAVRVAAAERRELILELRDRGWSLRRIADLVGVSTTTIHQIVQPRKKG
>NZ_CP021122.1|WP_065209234.1|429445_431593_+|hypothetical-protein
MAIQRISTQHSERLNPDQYWPQWDEDGYIEAANSQAANAQKAFQSGEAVAVQASGVVSQTMEGQTADAAMARFASDGAKLENRGGVHSSNATINGLMAQNVANRKASINFLLANHEADVEAIKATAVAQGWTQNELQDEVARADDGYRQQIETVATNSDQAHEELKGQLNTGEAPSAPASMPGGVPGEGSPKLDGLDPEVEKAVSSAMGTGGGMGDMSQMAGMASGLLSPLTGALQSPPGADMLNQAGQQGFQMGQQALQALLGQGGGAAELTPDQVEELIAGQGGDSTDGLPGGNDPSAAPSSDEGPKFENPDRPAETPAAETKTDTAKADADTKTEPAAAAAPSPAAEPVSAAPPTSAMHPTTELSGDSGVATAPAPATNLSGAGAAPMGGTATLGAPGMGAAAGGFAGAPAGGMGGGFGAPMMGGAPMMGGAAPQAGAPARGAAPVATATSADQRISAATLSAPVTDPREGNPATANASQAAPVAAVAPVTAGASRVADRHVVQVRRVMAHLLGEYRRVGLAGDLAIGVLKDGTFVYATWDGLGFLPHGVRLPANVIPLSEFPLSPLFRQDFVAYAPGALIAVAAELQLIPEVSVIFTTNSEDVGITVTAADLRGLTLPNATIERTAFQTLPVEEHENAAKLTRMVWEIGDLPDMATITADLRGVRGTAYANRVLAAYLLADASRFEGTAEAGYALHQALWLPSPLDEQQPV
>NZ_CP021122.1|WP_079673336.1|428620_429286_+|hypothetical-protein
MATGGRIEVQADETGGRALAQQMVNALPSGVTEIEYDTEELLDQAADWQAKADLLRELAPEAREITEWAEGASGEFKSEYETPGVYNNTYTDCGTGSDRIEKEVTKLADDIERWAQSIQWMAENMEEVQKIAANRTEQIDADVSGGAGSGSAVDESARKVDVLSDSGETASQSSPMPPTYDGGSTPVVGADPQSAPAAPTLDGSSAPVVGSRSVDGGTTEI
>NZ_CP021122.1|WP_065209232.1|427240_428590_+|hypothetical-protein
MAAESIDSLFDLDDDTDNGASAAVVTAPAPAPAPAQATAAKADEPKPTDTDDPLRKASEPFIPQPVVNDAPPPGFESRVEEHEPTFHDVDADDISKVANDDRYGDCAPDPFASNNVTPDLVNKNDGAPTTAPESDDDDLPPWERDRKEREKREQEEREAMRRAHEEAISEGSMTLPGESDEQLGGFADDTGSGSGSRADFIRAKVANNGLVEKSKDFVKRNPRPVIVGVIGLVALLVMAVVLPAGDPASEPAPPAALPPDVAVEVPADPSLGEPVTLLPRTVAADCGPGQTNPALAFNNNQQDAWICPRAHGIDGAIMNIQFKNTVQVVSVTVMPGWNYVAPNGRDRWNEHRVVTRIRWRAGGKEFIHNIDPTRAGSTFTFNPPKGVATNEMSLTIFATERPNAAGAEVDPETGGGGILPPILGGGDGGADVDRTFAIGSIVINGYELG
>NZ_CP021122.1|WP_065209231.1|427002_427251_+|hypothetical-protein
MRRPRPYNPDPDTLRLLDEFRDVSAESRAHAQALSEFRQRRAEIVRQLIGRGLTYRRIAAEVGVSKSFIQALGATEGAANGC
>NZ_CP021122.1|WP_131831763.1|426736_427006_+|hypothetical-protein
MTDIREAVDAGVTATEAFGARRGGLVGVWLDDPDRPGVSAFVNQGRLTRLVIPQAYMGMRREELEAVINAVIINAHLDASPAIRARSAA
>NZ_CP021122.1|WP_065209240.1|436810_438235_-|transposase
MTTAAPTETVLRGYRFVLDPTPTQAEMFESHAGGARFAYNHMLARVKANLSQREAERSYGIPDEELTPALGWSAKDLNDAFNAVKDADAPWNRENSSRIYLYATRDLAQALKNWSDGKKGARRHMGFPRFHSRRSRKSFTFTATDKTLLDTRHHVKLPKIGVVHTLESTRRLYRLIEQGRAKVKTATVSLHRGRWQVSILAEITRAVTPQRKQPRVVGIDLGVKDWIVAATPDGAEVLRVPFPAELKKLDERKRKLQRRYRNRQRGDKRTGQQASNRWRQAQKRINKVDYKMAAIREDMLHKATTGLARLFDVVVMEDLNVAGMKTRGGAHKRGLNRALQQSGMAMTRTMMSYKASELILVDRFYPSSKRCSSCGETKAKLTLGERVYRCGNCGLETDRDLNAAINLARQADVHMAESPSVSARGAERKPAKPSGAAAAGDEARSRRRQRQSVGVTGNGGTSPRTQLNEEHSAA
>NZ_CP021122.1|WP_065209241.1|438231_438459_-|helix-turn-helix-transcriptional-regulator
MNDTAANNEQRDAIARLRAAEEQYRTAKEAARTARDARNEAIRTARRTGVHQTVLAEVIGVKRAMISNIEHGRRS
>NZ_CP021122.1|WP_065209242.1|438646_439033_-|hypothetical-protein
MTVTAHATRTADGWWAVTVPEIEGLHTQSKRLDRVREMVVDAAKVLGVEITADDVTVVRRLTDAELQRRVDETNALRAQLAELQRRVAEETRETALALHRTGMTVRDIAVFLDLTPGRIGQLVSGADD
>NZ_CP021122.1|WP_131831762.1|439203_439938_+|hypothetical-protein
MMTSKSVKYITAGLAAAAVLVLPACSNQVNTTAAEDIPVTKVTVTTSTAPAAEQAPIPTPTIPRASDRYAELDGVVRDAAADAKMMWERATGVKLPSLTVVPEGDPAASRCINDDPLSLMWACDSGVIVYRPAMLKQRMDAGGIGPVMVYTSHEVAHIGMAANGFGAGETSHREEKAAMCGAGAYMRYVVEGKSKEDFTSSRDGALEAGLKSYPLDGSYVSTDVAKDFLAKYREGFDSGQLCIG
>NZ_CP021122.1|WP_065209244.1|439969_440248_-|hypothetical-protein
MTARLVVIAAVAIAFIAGIAAAVMILTGDDAADAVTAAAVPVNPEKVSVTRHVETTMTSDAIESAYAAVQAFKQQDTGRTCTQISPLAKRCD
>NZ_CP021122.1|WP_065209245.1|440508_440982_+|helix-turn-helix-domain-containing-protein
MTSDDLMTTGEAAARLGVSRQTVVNLCEQGKLPSVRAGSHRRVPRDAVESYDLQRRGWETDGHQKSLALHALVVGELLRDPERVRAKARRNLRRFPEDADTHRRRWEELLDEPLPVLITAMLDTSDTGVTLRAHTPFAGVLNAEDRARVNRAYRATR
>NZ_CP021122.1|WP_065209246.1|441055_441385_-|hypothetical-protein
MTSETNNSEARDYLTRMGLAFRYQTRPALDPVRTLGVNHPERFALLTSAWQRCLDAARTVHSRYEEDRNSSGPLSEIAVEVRNCALSGLARTWEHLVDGYLSDIAEADQ
>NZ_CP021122.1|WP_065209247.1|441410_441908_-|DUF732-domain-containing-protein
MIIRALSVVVAASLIGVPATVSAETPEDMFIGLMVQEGVPFDSREDALRRGWSACDRLGEGVTLQQMVDEAARNGGDTRSAYILPHLAASTLCPEHGWRVFGNGTPEPIPAPEPVPAPAPKPAPKTAYYPNCAAAKAAGAAPLHRGDPGYSSKLDRDGDGVACEK
>NZ_CP021122.1|WP_065209248.1|441904_442852_-|hypothetical-protein
MTRSIPWTPPPEVTEIGSHTYLIETDDLTGLLDLHGDGTATFRDHHVRLREDDSAYPFSYWNRINTDLKNGYHVTHLESVDDVPVYVINRNGTPDFRNTSPYCPFEVEAQDLTRAEAVDWVTVSRAVRAAGKSIAHLKDALNGSHKYFGVKARTEMLPSELLRKVTREVVIGPFTTSPHRKHLPGFGLQGFGALSGTGLVDDHAAHLAAAITVGGVLTPFMFSPDGPFRDNMKRLTDLVLSVEEHLLANGRSTRALPQTLRFAVGEAKAARRRECEFLDMSVVSVDRAREFALLRDDLPDMPDELVEALMGGDTP
>NZ_CP021122.1|WP_065209249.1|442848_443487_-|HNH-endonuclease
MTTPVIPFARDTRVVPILTAEDAARFWDRVQVNDGGCWVWTGAVGHNGYGNFYVSGAGTYRAHRVSWVWANGDVPHGFDLDHAVCRNKVCVNPEHLEVVTVNVNTWRGQGHFWSRDMQTLIRRVLFAKGDIDTNTFTTAAVQLLLNLGPSSVKRACSIGELRAHKGEGLDKRRYTPQWHIDRADLIDFIINRAAEDAGAPVLRALITERTAA

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Crispr_ID: NZ_CP021122_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021122_3

4313589-4313707

Orphan

Consensus_repeat	Method
TCGTTGATGGCACTGGTGTGGGCACCACCACCGACAGCCGTGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021122_3

>merge|NZ_CP021122|3|4313589-4313707|CRISPRCasFinder
TCGTTGATGGCACTGGTGTGGGCACCACCACCGACAGCCGTGCTGCCGCCAACAGAACCCGAACCACCCAGGGCATCGTTGATGGCACTGGTGTGAGCACCACCACCGACAGCCGTGCT

>NZ_CP021122|3|3|4313589-4313707|CRISPRCasFinder
TCGTTGATGGCACTGGTGTGGGCACCACCACCGACAGCCGTGCT	GCCGCCAACAGAACCCGAACCACCCAGGGCA
TCGTTGATGGCACTGGTGTGAGCACCACCACCGACAGCCGTGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021122.1\|WP_005064113.1\|4317377_4318301_+\|M56-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320685
NZ_CP021122.1\|WP_005127470.1\|4309256_4309913_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_005071414.1\|4316119_4317001_+\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|223856
NZ_CP021122.1\|WP_005071421.1\|4323999_4327032_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|223325
NZ_CP021122.1\|WP_005071406.1\|4304685_4305537_-\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|223856
NZ_CP021122.1\|WP_005138124.1\|4308118_4308505_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_005065069.1\|4306173_4307109_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274648
NZ_CP021122.1\|WP_005118096.1\|4307618_4308125_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226406
NZ_CP021122.1\|WP_005071418.1\|4319558_4321379_+\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|223520
NZ_CP021122.1\|WP_005071417.1\|4318381_4318765_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP021122.1\|WP_005064111.1\|4318777_4319377_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_030142800.1\|4327039_4328350_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181738
NZ_CP021122.1\|WP_074359962.1\|4321399_4323841_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP021122.1\|WP_005064114.1\|4317018_4317381_+\|penicillinase-repressor	unknown	unknown	gnl\|CDD\|367747
NZ_CP021122.1\|WP_005071412.1\|4309917_4311411_-\|isoniazid-inducible-protein-iniC	unknown	unknown	gnl\|CDD\|223771
NZ_CP021122.1\|WP_005064116.1\|4315433_4316123_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP021122.1\|WP_005138127.1\|4308583_4309237_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_062914962.1\|4307135_4307594_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NZ_CP021122.1\|WP_005071407.1\|4305552_4306032_-\|thiol:disulfide-interchange-protein	unknown	unknown	gnl\|CDD\|239309
NZ_CP021122.1\|WP_005065079.1\|4311407_4313291_-\|dynamin-like-GTPase-family-protein	unknown	unknown	gnl\|CDD\|223771

Protein	Function_ID	Function_description	E-value
NZ_CP021122.1\|WP_005071414.1\|4316119_4317001_+\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|223856	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones].	1.37975e-22
NZ_CP021122.1\|WP_005071421.1\|4323999_4327032_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	2.01154e-88
NZ_CP021122.1\|WP_005071406.1\|4304685_4305537_-\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|223856	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones].	6.45798e-17
NZ_CP021122.1\|WP_005064113.1\|4317377_4318301_+\|M56-family-metallopeptidase	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	1.6021e-30
NZ_CP021122.1\|WP_005065069.1\|4306173_4307109_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	5.23876e-110
NZ_CP021122.1\|WP_005118096.1\|4307618_4308125_+\|hypothetical-protein	gnl\|CDD\|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	4.28315e-06
NZ_CP021122.1\|WP_005071418.1\|4319558_4321379_+\|Hsp70-family-protein	gnl\|CDD\|223520	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones].	1.50388e-30
NZ_CP021122.1\|WP_005071417.1\|4318381_4318765_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.80091e-14
NZ_CP021122.1\|WP_030142800.1\|4327039_4328350_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP021122.1\|WP_074359962.1\|4321399_4323841_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	6.86933e-16
NZ_CP021122.1\|WP_005064114.1\|4317018_4317381_+\|penicillinase-repressor	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	2.20256e-26
NZ_CP021122.1\|WP_005071412.1\|4309917_4311411_-\|isoniazid-inducible-protein-iniC	gnl\|CDD\|223771	COG0699, COG0699, Predicted GTPases (dynamin-related) [General function prediction only].	3.00416e-10
NZ_CP021122.1\|WP_005064116.1\|4315433_4316123_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	1.52765e-31
NZ_CP021122.1\|WP_062914962.1\|4307135_4307594_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	0.000966056
NZ_CP021122.1\|WP_005071407.1\|4305552_4306032_-\|thiol:disulfide-interchange-protein	gnl\|CDD\|239309	cd03011, TlpA_like_ScsD_MtbDsbE, TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif. The Salmonella typhimurium ScsD is a thioredoxin-like protein which confers copper tolerance to copper-sensitive mutants of E. coli. MtbDsbE has been characterized as an oxidase in vitro, catalyzing the disulfide bond formation of substrates like hirudin. The reduced form of MtbDsbE is more stable than its oxidized form, consistent with an oxidase function. This is in contrast to the function of DsbE from gram-negative bacteria which is a specific reductase of apocytochrome c.	3.53071e-32
NZ_CP021122.1\|WP_005065079.1\|4311407_4313291_-\|dynamin-like-GTPase-family-protein	gnl\|CDD\|223771	COG0699, COG0699, Predicted GTPases (dynamin-related) [General function prediction only].	1.86063e-21

>NZ_CP021122.1|WP_005065079.1|4311407_4313291_-|dynamin-like-GTPase-family-protein
MSDTAQDGQQQLVLINELLGHVRKIAGENDRGDLIDRLDRADQLLVDRPLRVVVAGQLKQGKSQLVNSLLNMPVARVGDDETTSVTTVIGYGEQPSAALVVAPAEQYDGGGLAGEPEIIPIPVADIGKDLKRAPQAQGREVLRVEVKVASPILKSGLCLVDTPGVGGFGQPHLSSTLGLLPDADVMLMVSDLSSEFTEPELVFIQQALDLCPVAAIVNTKTDLYPHWRAVVAANSAHLQRAKIAVPAIAVSSALRSHALQLNDKELNTESNFPALVTFLSNAIADQQASTRQQAIAEIGSASEHLTLTLEAELSALQDPQSRDELTSDLERRKREAEEALAHTALWQQVLGDGITDVSTDVEHDLQSRFRRILQRTEEVIDRTDPTKNWAEIGAKLEQAVANSVGNNFVWAHQRAMHLAAQVAETFAIDGLESVKMPRLRASEMGADLSDLKSLSKLEAKQIKLGHKAITGLRGSYGGVIMFGMLTSVAGLGMFNLISLGAGAMLGKKTYNEDMENRMLRIRGEAKTNVRRFLDDVSFVVLKESRDRLRLVQRQLRDHFREIANQTTRSLNESLQAAIASARLEAEERDARTNEVERQLHILRQVNSHVERLQPTDEQAARRATRDV
>NZ_CP021122.1|WP_005071412.1|4309917_4311411_-|isoniazid-inducible-protein-iniC
MSSVAQARVIIGDAMLAYQNDSRYLRVAEPHDELRRIAARLDEPIRVAIAGTLNAGKSTLVNALVGEDIAPTDATEATRIVAWFRHGAAPRVTANFFSGVRQDIPIRREGGLSFELDRLDPASVADLDVNWPAPELNEITLIDTPGTSSLSTDVSERSLALLVPEDGVPRVDAVIFLLRSLNAADIGLLTQIGKLVGGERGGAVGVVGVVSRADEIGVGRLDAMLSAREVAARFAGEMERTGICQAVVPVAGLLALTARTLRQAEFVALQRLAELDPQVLAKALLSVDRFVREDDSLPVDAQTRAALLHRFGMFGIRISVAVMRVGVTDATGLAEELLERSGLVELHNIIANQFGQRAGILKSHTALLSARRVLTTYPVHGGRRVIDNIDPLLADTHAFDELRLLAELSSHSTTLTEHETMLIRRLLGSFGTDAAARLGLDETRSDPRRAALDAVGRWRARAEHPLNDPFTSRLCLAAVRSAEGILTQLSAHDRPAY
>NZ_CP021122.1|WP_005127470.1|4309256_4309913_-|hypothetical-protein
MMMRLFVATLALVAGFSTATAAAEPTPSPAGPASKPVPAGVWISPAEIPMNSDYHWSAVSPTATGRAAFLSMRLCGSPSADVLPPASAIATQAASGVAASVVQAAGQWPEGNTEGASAFQSGIRSQLNYCPGVGDVISVDLRPAPSWYGFAATLLIGKERDNPTSEVHIYNVVPPESGTVSELAVTVPRTGREPSPWKPVDDATVLRALAQPLCKGSC
>NZ_CP021122.1|WP_005138127.1|4308583_4309237_-|hypothetical-protein
MRGWLRAISALVVISGLGAAVPAAAEPKSLPDSVWINPRDIPLDRASHWAPLPRSAAPVDRPAFWSANLCFSLGESLPQSPESASATVSSDESGWTAVEVVAHWPGEAVVTDQYASTVYRSLRGRLDHCFNAIGAQVSVTDLTNGHAATVTLPAQGGKQPQYHLYVVQPPGTGTVAELTVTNAITGAAGASWVEADDHQVLRDLAAPICRTAKSTAC
>NZ_CP021122.1|WP_005138124.1|4308118_4308505_-|hypothetical-protein
MHGRGVLSGVCGIATIIAMAVLLTPVSIQVGTGETAQTVTCGMPVGPRLSRTAELDKISSAQNQSTNYHDQCAAKLDTRRMWAIPIGVLSFVIALCAAGHLWKENAPSSSPAQTRHGLSGPPGMRMAH
>NZ_CP021122.1|WP_005118096.1|4307618_4308125_+|hypothetical-protein
MSYPEPPEDPTMFNQQYHDQGPDQPNPWYKQPAVLIALAGAGVAVVAVIAALIITRSDDKPAPAGNTSSVSSTTSSTPTDSGGGGHEGHGGHGGGNTTVTETQTVPESPTSQDTTTTEPTTTTTTTTEPTTTTTQPTTTTTQPTTSTRPSVVVPIPGGGNIQVPVGGQ
>NZ_CP021122.1|WP_062914962.1|4307135_4307594_+|hypothetical-protein
MSQTPKPPEDESYFSEMIKESEKPTPWYRTGPAIVGTIAAIIAIVAVLMTIVLSTDKRVVRDNTPLTSTPSVSSTAPTAQPTSPSESSTAVPTATEAPPEPVAPAQTSEPTYYETPTSTIYRYPIPAIPSPPPIPPIPAIPQIPQIPQIPGL
>NZ_CP021122.1|WP_005065069.1|4306173_4307109_+|LLM-class-F420-dependent-oxidoreductase
MDFRVFVEPQQGATYSDQLRVAQAAEELGFSAFFRSDHYLAMGGADGLPGPTDAWVTLGAIARETTAIRLGTLVTSATFRHPGPLAVTVAQVDEMSSGRVDFGLGAGWFSEEHEAYAIPFPSLGERFDRLEEQLEILTGLWTTPTGDTYSYAGKHYTVTDSPALPKPVQEPHPPIVIGGLGVKRTPALAARFAAEFNLPFQPVDVIADRYARVAQAVEAAGRPADSMVYSAAFAVCIGDTDTEIARRAANARREVEEITENSPLAGTPDAVAEKLSIYVDAGVQRVYVQLLDIRDLDHLEFFASTVIPQFS
>NZ_CP021122.1|WP_005071407.1|4305552_4306032_-|thiol:disulfide-interchange-protein
MAVLALTLSVGLSGCSGTEKGETSSAPSSRLLNFTAQTIDGADFAGSSLAGKKAVLWFWAPWCPTCQKEAPDLQKATTAHPDVTFVGVAAQDQVPAMRDFVTKYGLTFIQLADTDAKVWALYDVTHQPAFAFLGSEGKAEVVKSPLSGPELDKKIRQLH
>NZ_CP021122.1|WP_005071406.1|4304685_4305537_-|cytochrome-c-biogenesis-protein-CcdA
MIDTAALTFALGAGLVAALNPCGFAFLPGYLGLVIAGSDGTASRMTAIARAATATVAMAGGFLTVFGVFGLVISPVVASAGRYMPFATVVIGVVLVALSIWLLCGRELTLVLPRVSGGAPTASLLSMFGYGLTYAVASLSCTVGPFLAVISTTFKQGSIVSGVLAFIAYGVGMTVTVGVAALAVALLGNSVQATMRKVLPCVGRIAGVIVLLTGLYVAYYGYYEIRLNFGDGSADDPVINAAGAVQTWLVGVVDATGVWPPIGGIALIVAVAAVSSYAVRKGR
>NZ_CP021122.1|WP_005064116.1|4315433_4316123_+|thioredoxin-domain-containing-protein
MRRSENGKRDIWIAGILGVVIVALATYLLVDHRSQSTASTDSPAVTGHHSSLARLHPHDPLALGPVDAPVVLIIYSDYRCPFCAKFSRDTEPQLIERYVNAGKLRIEWRDLPIFGTQSVQAAKAGRAAAEQGRFWEFNRAVYRHAPDRGHAELTDKILLDRAREAAVPDLARFQTAVEGDRLLPAVQQDIQEAVAIGAASTPVFLINDQPVVGAQPLDVFISVIEQAQR
>NZ_CP021122.1|WP_005071414.1|4316119_4317001_+|cytochrome-c-biogenesis-protein-CcdA
MIDVGVLGALLGGVLTLVSPCSALLLPSFFAYSFDRTGLLLRRTGLFYLGMMTVLAPLGAGVGAIGALLTEYRSQVTTTGGLLMTTLGAAIIAGIGFRIGPAARLAARLDLSSALSVLLLGTVYALAGFCSGPLLGSVLTVAAIGSSPIYGALLMSLYSLGMAAPLFALAFAWGKLGLSRRRWVRGREIRIGRFRTHSTNLVSGGMFIAIGVFFLATDGTAALGGLTGSDTQYDVQARLQSLTAGLPNAAVALGIACAAFVVVLMRLLRARITAAGDARKRSDSTREDADDRR
>NZ_CP021122.1|WP_005064114.1|4317018_4317381_+|penicillinase-repressor
MRDMFGLGEREATIMELLWSVAEPVTVRDVLDRLERPLAYTTVMTVLDNLHNKGHVTREKVGRAFQYRAAETREAAAARMVREVLAASGDAEGVLLHFAGATSPEESTVLRRILRRGGLA
>NZ_CP021122.1|WP_005064113.1|4317377_4318301_+|M56-family-metallopeptidase
MTVALVLMAGAALIGVAGPACLRPTVRPSLLPAAALAAWLGALLAFLVLTTLSATLLLFPHVLDTSGVRTLVGGCLSGTVPHSSFGTLVQLGISLLPLTILARVAVVAIRSLRCARRCRARHFWMLQAATCRSGEVHWIDDPRPIAYSLGGARGAVVATHGVRHLGERQCAAVIEHEMAHIRGRHHVAVLCADIAAAALPMLPLMRRAPAMVRLMVELAADDAAARVHGPPTVHAALLAMSQSAVAVPGVLHMSSESVAVRLLWLRTQGTAGRTPMGRARLMLSFALLPTTLAGSAVVALFRAYCTF
>NZ_CP021122.1|WP_005071417.1|4318381_4318765_+|DoxX-family-protein
MIPTGARLVFGVIFLLEGTQKVFGWWSGSPTGSGHPEPFLNWPYWWAGVFELVLGTLLTVGLRTRLAAVLAAGMMAYAYFFEHLPVHWEPMQNGGAFAATFCWGLLLLAVTANDTRLSLDRVLARRA
>NZ_CP021122.1|WP_005064111.1|4318777_4319377_-|hypothetical-protein
MGNNLLDFVMALVRDQDMAAQYAANPERVIADAHLDGVQPSDVSALIPVVSESMPSISQLAAHPTASDLTHAAQIPADNIWASGAAVSAFDSPFTAPTHDPSLDAGLHAATDAVTDLAPRQDAITVPDQFTAPTDSAVATIDQFQAPLQSTDGGFEPQQFGADAGVTGSADPGLHDPFFDQGHLGHHPGIDHDPGIDHF
>NZ_CP021122.1|WP_005071418.1|4319558_4321379_+|Hsp70-family-protein
MANALGLSIGATQLVATPDDPQSQPVVRSSILTLHEDGPPEVGVPSQPGLTLTGFVGRVGDPVGIVAADGSVHRAEWALTEAMRVLIADAVSSANFTAPPVLSASIPAHWSPQTVNTLRDAIDRVPAFAPGGRQLKLIPDARAALESLAAGPGTPDRGVMVVCDLGGSGSSITLADAARGFQQIGQTLRFADFSGQQIDQMLLTQVLTDLNQDPEGTTSVGALTRLRDQCRLAKERLSGDTATSVPVQLPGITTDVRLTRAELEGHLRGPLSNLINAIQDTVERNGIHPANITAVASVGGGASIPLVTQQLSERIRVPVITAPQPQLAAARGVALLATRPDLPPQDATAMRPVEQPPGDATMMRPVPTGTGTFAAPVAAAASEEPELAWSQDDSAPDLAPLQETGYQSGYTVDLDDEYQGPTEATNARPELRFSHGPYADGDDYDDYPPLPWYRRPLVWFIAAAAVAGIAFTGMMVSLTSSESPAPATTTPSVNVVPSTGDAPAEPPPSPEPPPPPQTHTVTQSVQPPPPSPEPPPPPPPTTTTTTTTPPTTTTTTTTTTTTTTTTTTPPTTTTTQPTTTTTQPTSTSRPAITIPGLPPIPIGPRN
>NZ_CP021122.1|WP_074359962.1|4321399_4323841_+|helix-turn-helix-transcriptional-regulator
MSGTFDGIASAITAITGPLSAGHAVKVLVNGTAGSGKTFVLSRIREALGSAGTPAVNHVPEAAPGPNTGPFVIDDADSLTDRQLETLRAVVENDPAAIMVVAAAPRRNPALRALFQALERESPAITLGPVNATDIGRMSPLAAPFAEQIAAASGGVLALTTAAVERLGDPDPLQSALRAIDTRVDELLRRLSPMAQAAVLLMSLDPGIGASDVAAALALPDAADLVDGALASGLIAGPGHVAFAARVHGCAARLLGAARHLDLERSLLRTQLEMGSVSADLALALVAHGLRDLEVARLLSNWATTESDPLSAADLYRAALTAGAEPDPIRVPLAESLARAGDLAAAAAQADEALASTDPAQRTAGVRVAAAIACHNGDSGQAAALYSWLGADMDGLTALSASPVFVGTGQLTNGRKSLEDNVGAPPTTSATAMRNAALGVIASVEGRGQEALSLLGQAVTQQPSTSSFTPDSTVALAALTMLHSGDTARARSILTGAIRADRRHDVFGVRHRLLAAWIAMLSGDLSGAVQWLPGAEVVLSRRDRLFAESLRTGIARRHGDTGPLRQHWQASMDALSAYSIDLYTLLPVGELWVAAARLRTLDVMTHHLDRAFAVLAHLGDPIAWSAPLRWAGVHAAILTNSPENLAPHGQALAAGAGSSTYARTLATAGRTWLRVLANHVDGEEVDSAARMLADTGLGWDATRLASQAALHANDPKVAAAMLALARDLRSPSAAADGESTPSSAAHSPTSTRLSEREREVAELLLRGLPYRDIGAQLFISAKTVEHHVARIRRRLGAESRSDMFSMLRAILTP
>NZ_CP021122.1|WP_005071421.1|4323999_4327032_+|4Fe-4S-dicluster-domain-containing-protein
MSTATITLGIIGVIFSLVAWGSFFGGVVKMVRVILSGQPDRTRFRPFLPRLKQLVVEVVAHTRMNKFRTVGWAHWLVMVGFLGGFPLYFESYGQTFNPEFHWPIIGDTFLWHLWDELLGIGTVIGIVTLIIIRQLNHPRKPERLSRFGGSNFFAAYTIEMIVLVEGLGMVLVKSGKIATFHNSHPSSDFFTMNVAQLLPESPIMVSVFAFIKMMSGGLFLLLVGRKLVWGVAWHRFAAFFNIYFKRNADGSVALGAAKPMMSGGKVLEMESADPDVDAFGAGKVEDFSWKDLLDVTTCTECGRCQSQCPAWNTGKPLSPKLLITSLRDHTYAKAPYLLAGEDKSKLSEAEIAEGERQLVGGEGAVIDHEVLWSCTTCGACVEQCPVDIEHVDHIIDMRRYQVLIESEFPGELAGLFKNLENKGNPWGQNAKDRLNWIEEVDFDVPVFGQDVDSFADFEYLFWVGCAGAYEDRAKKTTKAVAELLALAGTKFLVLGADETCTGDSARRAGNEFLFQQLAMQNIELLNSVFEGVEQKQRKIVVTCAHCFNALGNEYPQVGGDYQVVHHTQLLNRLVRDKKLVPVAPVSQDVTYHDPCYLGRHNKVYTAPRELIGASGAAITEMPRHGERSMCCGAGGARMWMEEQLGKRINIDRVDEALSTPASKIATGCPFCRVMLTDGVTARDDSAAVEVVDVAQLLLESVGRTEDIRKALPAKGTAAAAAAERAATKTAEPEPVVAEEEAPATTKTEAAAPATEAKPVSGLGMATGAKRPGAKKAAAPAEAAPATEAAPAPVKGLGMATGAKRPGAKKTAAETSTAEAPAATPTAEAAPAAPVKGLGMAAGAKRPGAKKATAETGAATPAAPASPPASQAPAAAAPPAPPVKGLGMAAGAKRPGAKKTAPAAPAPPAPEATAVPSESEAPATTETSAVAEPPVKGLGIAAGARRPGAKKAALATESAPEPAQPAATASEPTEPATSAPKDEAPETGSTPEPPVKGLGIAPGARRPGRRN
>NZ_CP021122.1|WP_030142800.1|4327039_4328350_+|pyridoxal-phosphate-dependent-aminotransferase
MDSNATIETVSTDNLPIDVPPRVPGLSPRQHQRVFAQSTKLQDVLYEIRGPVHAHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSKGILPARRAVVTRYELVDGFPYLDVDDVFLGNGVSELITMTTQALLDNGDQVLIPAPDYPLWTAATSLAGGTAVHYLCDETNGWMPDIEDLESKITERTKALVIINPNNPTGAVYSREILTKMVELARKHQLLLLADEIYDKILYDDAEHISVASLAPDLLCFTFNGLSKAYRVAGYRSAWLAITGPKDHAASLLEGVNLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDVAWTKLNEIPGVSCVKPQGALYAFPRLDPEVHHIHDDDQLVLDLLLNEKILLTQGTGFNWPEPDHLRIVTLPWARDLAVAIERLGNFLASYRQ

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Crispr_ID: NZ_CP021122_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021122_4

4620310-4620404

Orphan

Consensus_repeat	Method
GCCAGCCCGCTGAACCCCAACAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021122_4

>merge|NZ_CP021122|4|4620310-4620404|CRISPRCasFinder
GCCAGCCCGCTGAACCCCAACAACCCCGCCAACCCGGCCAGCCCGCTGAACCCGAACAACCCGGCCAATCCCGCCAGCCCGCTGAACCCGAACAA

>NZ_CP021122|4|4|4620310-4620404|CRISPRCasFinder
GCCAGCCCGCTGAACCCCAACAA	CCCCGCCAACCCGGCCAGCCCGCTGAACCCGAACAACCCGGCCAATCCC
GCCAGCCCGCTGAACCCGAACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021122.1\|WP_005120026.1\|4628414_4629479_+\|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|238341
NZ_CP021122.1\|WP_005071723.1\|4613618_4614506_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_005071728.1\|4617740_4618343_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP021122.1\|WP_005071722.1\|4613026_4613557_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP021122.1\|WP_005138247.1\|4609994_4610912_+\|methylisocitrate-lyase	unknown	unknown	gnl\|CDD\|131370
NZ_CP021122.1\|WP_074360002.1\|4612101_4612782_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021122.1\|WP_005071727.1\|4617331_4617751_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP021122.1\|WP_005101757.1\|4622290_4623139_+\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP021122.1\|WP_005063840.1\|4626682_4627936_+\|NADH:flavin-oxidoreductase/NADH-oxidase-family-protein	unknown	unknown	gnl\|CDD\|240084
NZ_CP021122.1\|WP_074292112.1\|4627866_4628349_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|281995
NZ_CP021122.1\|WP_005063831.1\|4618386_4619976_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235731
NZ_CP021122.1\|WP_005138245.1\|4608492_4609998_+\|MmgE/PrpD-family-protein	unknown	unknown	gnl\|CDD\|224990
NZ_CP021122.1\|WP_005071732.1\|4621615_4622281_+\|glyoxalase	unknown	unknown	gnl\|CDD\|372667
NZ_CP021122.1\|WP_005071720.1\|4610908_4612030_+\|bifunctional-2-methylcitrate-synthase/citrate-synthase	unknown	unknown	gnl\|CDD\|237590
NZ_CP021122.1\|WP_062914965.1\|4624095_4624887_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181131
NZ_CP021122.1\|WP_005063839.1\|4625969_4626560_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP021122.1\|WP_016343627.1\|4623143_4624004_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NZ_CP021122.1\|WP_005071725.1\|4614624_4616895_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|235367
NZ_CP021122.1\|WP_005112528.1\|4624899_4625973_+\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|226326
NZ_CP021122.1\|WP_005103161.1\|4620466_4621564_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274934

Protein	Function_ID	Function_description	E-value
NZ_CP021122.1\|WP_005120026.1\|4628414_4629479_+\|galactose-1-phosphate-uridylyltransferase	gnl\|CDD\|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	1.66003e-113
NZ_CP021122.1\|WP_005071728.1\|4617740_4618343_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.85926e-07
NZ_CP021122.1\|WP_005071722.1\|4613026_4613557_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.65024e-30
NZ_CP021122.1\|WP_005138247.1\|4609994_4610912_+\|methylisocitrate-lyase	gnl\|CDD\|131370	TIGR02317, Methylisocitrate_lyase, methylisocitrate lyase. Members of this family are methylisocitrate lyase, also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. This enzyme acts in propionate metabolism. It cleaves a carbon-carbon bond to convert 2-methylisocitrate to pyruvate plus succinate. Some members of this family have been annotated, incorrectly it seems, as the related protein carboxyphosphoenolpyruvate phosphomutase, which is involved in synthesizing the antibiotic bialaphos in Streptomyces hygroscopicus.	1.72028e-143
NZ_CP021122.1\|WP_005063839.1\|4625969_4626560_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.72256e-07
NZ_CP021122.1\|WP_005071727.1\|4617331_4617751_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	2.31723e-22
NZ_CP021122.1\|WP_005101757.1\|4622290_4623139_+\|DUF2510-domain-containing-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	2.65198e-41
NZ_CP021122.1\|WP_005063840.1\|4626682_4627936_+\|NADH:flavin-oxidoreductase/NADH-oxidase-family-protein	gnl\|CDD\|240084	cd04733, OYE_like_2_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	9.42384e-165
NZ_CP021122.1\|WP_074292112.1\|4627866_4628349_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	4.00501e-11
NZ_CP021122.1\|WP_005063831.1\|4618386_4619976_-\|AMP-binding-protein	gnl\|CDD\|235731	PRK06188, PRK06188, acyl-CoA synthetase; Validated.	0
NZ_CP021122.1\|WP_005138245.1\|4608492_4609998_+\|MmgE/PrpD-family-protein	gnl\|CDD\|224990	COG2079, PrpD, Uncharacterized protein involved in propionate catabolism [General function prediction only].	7.01114e-146
NZ_CP021122.1\|WP_005071732.1\|4621615_4622281_+\|glyoxalase	gnl\|CDD\|372667	pfam13669, Glyoxalase_4, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	1.98773e-08
NZ_CP021122.1\|WP_005071720.1\|4610908_4612030_+\|bifunctional-2-methylcitrate-synthase/citrate-synthase	gnl\|CDD\|237590	PRK14033, PRK14033, bifunctional 2-methylcitrate synthase/citrate synthase.	0
NZ_CP021122.1\|WP_062914965.1\|4624095_4624887_+\|SDR-family-oxidoreductase	gnl\|CDD\|181131	PRK07814, PRK07814, SDR family oxidoreductase.	2.078e-153
NZ_CP021122.1\|WP_016343627.1\|4623143_4624004_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.90611e-09
NZ_CP021122.1\|WP_005071725.1\|4614624_4616895_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0
NZ_CP021122.1\|WP_005112528.1\|4624899_4625973_+\|diacylglycerol-kinase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	2.24659e-114
NZ_CP021122.1\|WP_005103161.1\|4620466_4621564_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	2.09098e-76

>NZ_CP021122.1|WP_005063831.1|4618386_4619976_-|AMP-binding-protein
MPDPFDPLHGSINSGHLLVSALKRNRDAPALVLGDVTLTGAQMADEISKYIQAFIELVPDPTDGQGMLALNRPEVLLVIGAGQLLGTRRTALHPLGSLDDHAYVLADAKITTLVIDPTPQFVERAAALVAKVPTLTRVLTLGPVPVELAEVGQDLVAAAAGFAARPLTPINLSPDHINGLTYTGGTTGKPKGVIGTSQSILTMTQIQLAEWEWPERPKFLMCTPLSHAGAAFFMPTLMKGGSMVVLPKFDAGAVLAAIEEHQITATMLVPSMIYALLDHPDSRTRDLSSLQTVYYGASAINPVRLAEAIERFGPIFAQYFGQSEAPMVISYLAKGDHDAKRLSSCGRPSAFLRTALLDENDRPVKQGEPGEICVAGPLVAGGYWGLPEQTAETFKNGWLRTGDVAREDEDGFWFIVDRTKDMIVTGGFNVFPREVEDVVAEHPSVAQVGVIGVPDEKWGEAVTAIVVLRSDASSDEEAVALMTSEIQSAVKERKGSVQSPKHVIVADSLPLTALGKLDKKALRQKYTTV
>NZ_CP021122.1|WP_005071728.1|4617740_4618343_+|TetR/AcrR-family-transcriptional-regulator
MGRKPQYSADDILDAALGLVAAGGPSAATATAIGRVLGAPSGSIYHRFPSRDELMARLWLRSIARYQDGVLAALALPDADDALAAAIDHAFDWTASNHNEALLLLQYEKADLVAHWPDTLATELKTLNSRVRKTLREYTDRRYGEVTTERIDKVMFALIDMPYAAVRRHLPDKGQPAPWLREFVHASAHALLARACPNKP
>NZ_CP021122.1|WP_005071727.1|4617331_4617751_+|PaaI-family-thioesterase
MITLDQAQQVLDAQPFSRLLGAAITRVDERGIQLSLQIRDELRQQSGFIHGGVLSYLADNAITYACGLGLGADIVTSGYTIEYVAPARDGARLVADASLVSAGRTKALGRCEISVEDHDGTATLVAVAQGTSMVRRSGT
>NZ_CP021122.1|WP_005071725.1|4614624_4616895_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MTTQPLKATTLGSARIGPRRELKRATESYWAGRISRVELEDVAAGLRRDNWTALAAAGLDSVPVNTFSYYDQVLDTAVLLGALPPRVAGIADDLDRYFAAARGNTDVTPLEMTKWFDTNYHYLVPEIGPDTQFTLNPAKLFGELKEAQALDVPARPVVVGPITFLALSKSVDGASAPIERLDEVVALYEQLLVQLAEAGVGWVQIDEPVLVTDILPNGPELAERVYGRLGTVADRPAILVASYFGELGAALPALARTPIEAIAVDLVYGSASAVASVPELAGKTLVAGVVDGRNIWRTNLQSALGTLASLLGSAESVAVSTSCSTLHVPYSLEPETELDDQLRSWLAFADEKVKEVVVLARALGEGRDAVAAEIAASNAAAESRRTDPRLNNGQIRTRLDAVLADGVSRGDAAERRRRQDERLRLPALPTTTIGSFPQTVEIRKARQALTRGEIDDVEYVRQMRAEVADVIALQEKLGLDVLVHGEPERNDMVQYFAEQLDGFFATQNGWVQSYGSRCVRPPILYGDVARRKPMTVEWATYAQSLTQKHVKGMLTGPVTILAWSFVRDDQPLGDTANQIALAIRDETVDLQNAGIAIIQVDEPALRELLPLRNSEKQAYLDWAVGAFRLSTSGVSDATQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAIGFSNSVGPGVYDIHSPRVPSTEEMATSLREALKAVPAQRLWVNPDCGLKTRKVDEVTSSLANLVAAAASVRADA
>NZ_CP021122.1|WP_005071723.1|4613618_4614506_-|hypothetical-protein
MNTVALEMVPPNVDGGLDRAADELRKLRQFSAEFGIDRRIAHVMIPSMIVEDGDRPLEMKPKLDVVDYWSIIRAELPAVRGLCTQVTSFSDETSLRGRLTDLTDAGMDGVIFVGVPRTMNDGDGAGIPPTDALSKFDDIVQNRGAILIPTRAGEQGRFSFKCDKGANFAMTQLLYSDAVVGFLHEFAHTSDHRPEVLLSFGFVPKLESKIGLIDWLIQDPGNEAVAREQDFVKALAAREPGERRPQLVDLYKRVVDGVAGLGFPLSIHFEAPYGLARPAFETFAEMLEYWSPAVS
>NZ_CP021122.1|WP_005071722.1|4613026_4613557_-|GNAT-family-N-acetyltransferase
MEPVELQTDRLMLRAVADADAAAIVDACNDPEILHYLPLPVPYTVGDARSFIAASTQEWAAGTRYGFGFFVMDTGELAGTCSLKPVTSGVLEVGYWSAAQHRRKGLTTEAVQRLCQWGFDVLDAHRIEWWAVVGNEGSRAVAEAAGFEMEGLLRQRACRRQEPADWWVGGLLPRPE
>NZ_CP021122.1|WP_074360002.1|4612101_4612782_-|hypothetical-protein
MASAAAVDWDEGREIIRFPYGCAGWDPALGDPAQRLVTLWATWHKGQNWPRLLGVVEELYDVSAVSYRDESDCIRCRPSSFQYRSVELATRWPEESSRGEPGRRVITGCVVGLRVISVVEPADADIQARQEERDRARRTLDLFGPPGVFGAVIPSRGDRVTVDLADPRLSVNDTRGYAGVVTGIAGQVSRAVHSPDGFYTGLLDINSEAPPPDELFIQLLCDRKPE
>NZ_CP021122.1|WP_005071720.1|4610908_4612030_+|bifunctional-2-methylcitrate-synthase/citrate-synthase
MTISTPTIHKGLAGVVVDTTAISKVVPETNSLTYRGYPVQDLAVQCSFEQVAYLLWHGELPNEGELALFNQRERAQRRLDRSLMALLAKLPETCHPMDVVRTAISYLGAEDPSEDDNTPDANYAKSLRMFAVLPTIVASDMRRRRGLDPIQPHSHLGYSANFLRMCFGEIPDPAIVKAFEQSMILYAEHSFNASTFAARVVTSTQSDIYSAVTAAIGALKGSLHGGANEAVMHDMIEIGDASKASEWLQSKRSRKEKIMGFGHRVYKNGDSRVPTMRAALEDVARVRDGGQWLEIYKVLESEMDAATGIKPNLDFPTGPAYYLMGFDIPCFTPIFVMSRITGWTAHIMEQAAANALIRPLSEYSGKPQRRLAC
>NZ_CP021122.1|WP_005138247.1|4609994_4610912_+|methylisocitrate-lyase
MSTLLASATDAATKRAAFRQGLSSGELLRLPGAFSPLVAKLIEEIGFEGVYVSGAVLSADLALPDIGLTTLTEVSARGRQIASVTDLPTLIDADTGFGEPMSAARTVAVLEDSGVAGLHLEDQVNPKRCGHLDGKAVVETAEMVRRLHAAVSARRDPNFVICARTDAAGIEGLPAAIDRARAYADAGADLIFTEALTDIGEFEKFRAAVDIPLLANMTEFGKSELVTADRLREVGYNVVIYPVTTLRLAMYAVEQGLHEINSAGTQSGLLEQMQHRSRLYELLHYAEYNRFDTEIFNFSLDGGQQ
>NZ_CP021122.1|WP_005138245.1|4608492_4609998_+|MmgE/PrpD-family-protein
MHVHSVRTRRSAEAFPRDQHLAWKIAEIASDPVAVPADTAAMVINRVIDNAAVSAASVIRRPVTVARRQAQAHPAAPGAHVFGIGGGYSAEWAAWANGVAVRELDFHDTFLAADYSHPGDNIPPLVAVAQQLGIGGDDLIRGLATAYETQINLTRGICLHEHKIDHVAHLGPAVAAGLGTMLKLDTETIYQAIGQALHLTTATRQSRKGLISSWKAYAPAWAGKVAIEAVDRAMRGEGAPSPIWEGEDGVIAWLLGGPEKLYKVPLPGPGEEKRAILDSYTKEHSAEYQSQAPIDLARRMRERIGDLEQIATIVLHTSHHTHVVIGTGSNDPQKFDPDASRETLDHSVMYIFAVALEDGTWHHERSYAPERAHRPETIELWNKISTIEDPEWTRRYHSTDPDEKAFGCKAVVTLKNGEVIADELAIADAHPLGARPFARDNYVNKFTVLSDGVIAPREQERFLSVAQGLADLKPGSLGALNPLVDAVVLDKAPTTPEGIFK
>NZ_CP021122.1|WP_005103161.1|4620466_4621564_-|LLM-class-flavin-dependent-oxidoreductase
MRFQLLDIVFHLPNPATRALAPAAERLNRVIETAVLAENLGFDSFAVGERHAGDVLSSAPTVLLGAVAAATDRILLSTGVTVLSLLDPVRAAEDFATIDQLSRGRLEIVIGKGNEDRQYPLMGLDIAKQYEYLQENYELLRRLLREEHVDWVGAHRHPLADATTLPRPYDGPFRIWHGSATSTFAVELAAKWGDPIVTANALQPKENYRVLIDRYRELYAHHGHDPAQLYVGAGSGGLYLADTTEQAIAQYRPIYEARLAQMAKLKAHPQAVGKFPSFESIEDAADRGPVLAGSPERVAEKILDWHEAFGHEFQSISLSPEADFEEQKDTLRRFAEEVVPLVRAEVKSTLWGPLDTRRAKGFTAV
>NZ_CP021122.1|WP_005071732.1|4621615_4622281_+|glyoxalase
MITELDSVLLDVPNLGEAKAAYSRLFNSSAPHPQLHLGLPEWASHPGMLFRVDHLDCAARTVARRGLALTVHGDLATGASNGVTLGLSGQPPAAPQPDADSCRIDHLVLFSPNRDRIIATLCGRLGFDLRLDRLQSWGAHQLFFRGAGLVVEVVLRDDDPSGPDSLWGIAWRTADIEASHARLSGAGATLGDIRNGHKPGTRVVTVKDPALAVPTILIEQR
>NZ_CP021122.1|WP_005101757.1|4622290_4623139_+|DUF2510-domain-containing-protein
MTTPNSGSWQPDPDGRYEFRWHDGQRWTDQVAHQGSVSTAPLGGAATQPAAPDQPAGNQFSGISGDLVDGRFSENEAKPISNQNAKLLRVRLGEPFLARQGSMVAYQGNVDFAFEGGGAAKFLKKALTGEGLPLMRCSGQGDVFLAERAFDVHLLNLNNAGLSISGKNVLAFSAGLNWNIERVRGASVVTGGLFNTTLRGTGWVALTTDGPPVVLNAAEAPTFADTNAVVAWSSNLQTQLKTSFKAGALIGRGSGEALQVSFQGQGFVIVQPSEGIPVVTAG
>NZ_CP021122.1|WP_016343627.1|4623143_4624004_-|helix-turn-helix-domain-containing-protein
MPASSPPTARVVRIVEMLAAAMQPKTVSEIAASTGISRATATAVVNELEAAGWVARDDELRYRIGASLPRAVDTSMPREAQQLLARIAAEAQAGVTVSCISAKALTVVAKAQAGRRAVTGFAVGQSIPLAFPAGSAVMPWRAAEEREQWLGTAAGLSARSGQRLLQQVSDCGYVVYRPDHDDTGMVDLLSDLLGSVGSEVMEAALRERLLRQLSRLTSRPYSPDELTSDEVLPISYLAAPIFDGAEARYELQLGPLLPRATRVVREALIATLMRGARELSGVLGDR
>NZ_CP021122.1|WP_062914965.1|4624095_4624887_+|SDR-family-oxidoreductase
MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQLREVAEKVQAAGRQAEVVVADLSDTEASAALAQKAVDRFGRLDVVVNNVGGTMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLKSDNASVINITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPRIRVNGIAPGSILTSALEVVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASPAGSFLTGKVLEVDGGLIAPNLDIPLPDLA
>NZ_CP021122.1|WP_005112528.1|4624899_4625973_+|diacylglycerol-kinase
MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGALAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSAGINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFANDLLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFGKPMEETPMLLQPGVLSLAWGSVVRQLAAGLGVELDEVTEVYEKLSAPEDFDISSGHIPAGTMAALHFEVRGIKDGRAVTVLEHFTRLREDLAPNWPQPAHEGGTYRVEITGEPSYLLDLGSFSARGDHNYANLIATAMRVVNAVPAVVAAEAGIRTTLDLPLITGKGRAV
>NZ_CP021122.1|WP_005063839.1|4625969_4626560_-|TetR/AcrR-family-transcriptional-regulator
MSARDTLIASVTGLVRRRGVAGTGLNALLEDSGVSRRTIYLNFPGGKQELVAEATRLAGNELTAIIKAAGDDVDPARGIQLFIELWKAQLAETEMQAGCPVVAAVLGRTEAPEAAAVAADAFESWRKILIDRLARYDVDGETARSLASTMIAAIEGAVIMSIAAQSTEALDDVGQRLVELVRLYVPAGAKPNPHVD
>NZ_CP021122.1|WP_005063840.1|4626682_4627936_+|NADH:flavin-oxidoreductase/NADH-oxidase-family-protein
MPDIHDPLPLANGQVLRNRLMKSALSEALGNAEQGPDHRLVQLFSRWGAGGYGLIVTGNVMVDHNHLGEPGNVVIEDDRHLEGLSRWAKATKDGGGLIWMQVNHPGRQANPLATKHQPVAPSAVRMSVPGWQAPRELTDVEIEDIIDRYARTAVVADTAGFDGVQIHGAHGYLVAQFLSPNTNRRTDRWGGDAQRRMRFVLEIVRRTKAAVSPGFAVAIKLNSADFQRGGFTEEESRGVIAALAAEGIDLIEISGGTYESPAMEGRPVVVSTSTQAREAYFLEYATTARAVAGDVPLAVTGGFRTTAAMNEAIESGACDVIGLGRPTTVNPEAAIELLSTRRDRLTVPDAALPLPARLAATARAKAFLSAHELQWHGTQMHRLGAGSDPDPSIGPWITALRLLKNNGVEAFRKRRSS
>NZ_CP021122.1|WP_074292112.1|4627866_4628349_+|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MDHGLAAPQEQRRRSIPKKEKFMTDKTLRKFRRERAMGRYLLNPAVGALAKLGVRTALASELETTGRRTGQLRRVPVSVQFDSTGAWVICQHGTRSGWGSNIAANPNVRIRQGNRWRTGTAQFRPDDDVVARGRGFGVIGARVVKALETTPISVRIDFTD
>NZ_CP021122.1|WP_005120026.1|4628414_4629479_+|galactose-1-phosphate-uridylyltransferase
MWRTRRELADGREILYFDSTPTERAAVDRRDLPPVSTQSQIRFDPLLGDWVTLASHRQTRTFLPPTDLCPLCPSTPERPTEIPEHAYEVVAFENRFPSLSLHAQAATPPAGAGFGRCEVLCFTSEHDTSFAQLEPRRARLIVDVWAERTKELSAIDGVKQVYCFENHGEEIGVTLAHPHGQIYAYPFITAKTARVLSNVDTHRKQHGTNLFGEILAAERATGTRVVTANDEWTAFVPSFARWPYEVSLYPHRQVADIPDLDDAARSAFAELYLDVLQRFACRFDNPMPYIAGWNQAPTVASGAIRDNWWLHLQVFSIRRAPGKLKYLAGSESGMGAFISDTTPEQVAAELRDVM

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021122_3	3.1\|4313633\|31\|NZ_CP021122\|CRISPRCasFinder	4313633-4313663	31	NZ_AP022578	Mycolicibacterium aubagnense strain JCM 15296 plasmid pJCM15296, complete sequence	166504-166534	6	0.806
NZ_CP021122_2	2.1\|436613\|32\|NZ_CP021122\|PILER-CR	436613-436644	32	NC_031107	Erwinia phage vB_EamM_Asesino, complete genome	140480-140511	8	0.75
NZ_CP021122_3	3.1\|4313633\|31\|NZ_CP021122\|CRISPRCasFinder	4313633-4313663	31	MN698244	Pelagibacter phage HTVC106P, complete genome	29757-29787	9	0.71
NZ_CP021122_3	3.1\|4313633\|31\|NZ_CP021122\|CRISPRCasFinder	4313633-4313663	31	NC_048170	Escherichia phage vB_EcoM_Goslar, complete genome	181507-181537	9	0.71
NZ_CP021122_2	2.1\|436613\|32\|NZ_CP021122\|PILER-CR	436613-436644	32	KM463009	Mycobacterium phage Power, complete genome	50977-51008	10	0.688
NZ_CP021122_2	2.1\|436613\|32\|NZ_CP021122\|PILER-CR	436613-436644	32	NC_029043	Mycobacterium phage SweetiePie, complete genome	50766-50797	10	0.688

1. spacer 3.1|4313633|31|NZ_CP021122|CRISPRCasFinder matches to NZ_AP022578 (Mycolicibacterium aubagnense strain JCM 15296 plasmid pJCM15296, complete sequence) position: , mismatch: 6, identity: 0.806

gccgccaacagaacccgaaccacc-cagggca	CRISPR spacer
accgccaccagaacccaaaccaccaccaggc-	Protospacer
.****** ********.******* * .***

2. spacer 2.1|436613|32|NZ_CP021122|PILER-CR matches to NC_031107 (Erwinia phage vB_EamM_Asesino, complete genome) position: , mismatch: 8, identity: 0.75

-----ctgtggaccggtgaggagctgactgagcactt	CRISPR spacer
ttcatctggggg-----gaggagctgtctgagcactt	Protospacer
     *** **.     ********* **********

3. spacer 3.1|4313633|31|NZ_CP021122|CRISPRCasFinder matches to MN698244 (Pelagibacter phage HTVC106P, complete genome) position: , mismatch: 9, identity: 0.71

gccgccaacagaacccgaaccacccagggca	CRISPR spacer
accgccaccagaacctgaaccaccagcacct	Protospacer
.****** *******.******** . . *

4. spacer 3.1|4313633|31|NZ_CP021122|CRISPRCasFinder matches to NC_048170 (Escherichia phage vB_EcoM_Goslar, complete genome) position: , mismatch: 9, identity: 0.71

gccgccaacagaacccgaaccacccagggca	CRISPR spacer
accggcaacagaacctgaaccaccgctcaaa	Protospacer
.*** **********.********    . *

5. spacer 2.1|436613|32|NZ_CP021122|PILER-CR matches to KM463009 (Mycobacterium phage Power, complete genome) position: , mismatch: 10, identity: 0.688

ctgtggaccggtgaggagctgactgagcactt	CRISPR spacer
acggcacgcggtgaggcgctgcctgagcactg	Protospacer
 .*  .  ******** **** *********

6. spacer 2.1|436613|32|NZ_CP021122|PILER-CR matches to NC_029043 (Mycobacterium phage SweetiePie, complete genome) position: , mismatch: 10, identity: 0.688

ctgtggaccggtgaggagctgactgagcactt	CRISPR spacer
acggcacgcggtgaggcgctgcctgagcactg	Protospacer
 .*  .  ******** **** *********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

436810 : 485660

Mycobacterium_phage(18.18%)

holin,transposase,protease,integrase

attL 457270:457284|attR 486522:486536

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065209240.1\|436810_438235_-\|transposase	transposase	A0A2I7RIF3	Vibrio_phage	9.6e-31	28.6
WP_065209241.1\|438231_438459_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_065209242.1\|438646_439033_-	hypothetical protein	A0A1I9SC84	Mycobacterium_phage	7.6e-07	36.9
WP_131831762.1\|439203_439938_+	hypothetical protein	NA	NA	NA	NA
WP_065209244.1\|439969_440248_-	hypothetical protein	NA	NA	NA	NA
WP_065209245.1\|440508_440982_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_065209246.1\|441055_441385_-	hypothetical protein	NA	NA	NA	NA
WP_065209247.1\|441410_441908_-	DUF732 domain-containing protein	NA	NA	NA	NA
WP_065209248.1\|441904_442852_-	hypothetical protein	NA	NA	NA	NA
WP_065209249.1\|442848_443487_-	HNH endonuclease	D0U234	Clavibacter_phage	1.8e-16	45.0
WP_131831761.1\|443483_444191_-	HNH endonuclease	D0U234	Clavibacter_phage	5.7e-16	43.1
WP_065209316.1\|444195_444399_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_065209251.1\|444548_445073_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_079640360.1\|445065_446244_+\|integrase	site-specific integrase	A0A1W6JQG4	Corynebacterium_phage	4.4e-45	34.2
WP_005065403.1\|446563_447634_-	PLP-dependent cysteine synthase family protein	NA	NA	NA	NA
WP_005083536.1\|447635_448598_-	metallophosphoesterase	NA	NA	NA	NA
WP_012296304.1\|448704_451140_-	transglycosylase/D,D-transpeptidase PonA2	NA	NA	NA	NA
WP_012296305.1\|451378_451717_+	WhiB family transcriptional regulator	A0A220NS58	Mycobacterium_phage	8.4e-10	45.3
WP_005063253.1\|451803_452925_-	ArsA family ATPase	NA	NA	NA	NA
WP_031600036.1\|452921_453965_-	ArsA family ATPase	NA	NA	NA	NA
WP_005063257.1\|454023_454185_+	DUF4177 domain-containing protein	NA	NA	NA	NA
WP_005063259.1\|454181_454655_+	RidA family protein	M1I5B0	Acanthocystis_turfacea_Chlorella_virus	4.3e-12	31.6
WP_005063262.1\|454654_455440_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_005063266.1\|455446_456292_+	DMT family transporter	NA	NA	NA	NA
WP_005063269.1\|456303_456978_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_005065409.1\|457073_457436_-	hypothetical protein	NA	NA	NA	NA
457270:457284	attL	NA	NA	NA	NA
WP_012296307.1\|457602_458400_+	endonuclease III	NA	NA	NA	NA
WP_005065410.1\|458401_459049_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_005100713.1\|459052_459817_+	CoA pyrophosphatase	NA	NA	NA	NA
WP_005063282.1\|459813_461079_+\|protease	acid resistance serine protease MarP	NA	NA	NA	NA
WP_005065413.1\|461052_462015_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_005065415.1\|462047_462569_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_005065416.1\|462818_463514_+	hypothetical protein	NA	NA	NA	NA
WP_005065418.1\|463603_465580_-	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	5.9e-79	37.3
WP_005065420.1\|465763_467383_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005064981.1\|467379_468351_+	ABC transporter permease	NA	NA	NA	NA
WP_005064980.1\|468343_469258_+	ABC transporter permease	NA	NA	NA	NA
WP_005065421.1\|469258_470908_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-21	32.8
WP_005065423.1\|470932_471676_+	hypothetical protein	NA	NA	NA	NA
WP_005065425.1\|472091_472973_-	HAD-IB family hydrolase	NA	NA	NA	NA
WP_005136567.1\|473356_474430_+	helicase	NA	NA	NA	NA
WP_074360127.1\|474426_475488_+	TadA family conjugal transfer-associated ATPase	NA	NA	NA	NA
WP_052621576.1\|475820_476198_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_052621575.1\|476194_478177_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.8e-104	39.8
WP_078313689.1\|478918_479506_+	MPT63 family protein	NA	NA	NA	NA
WP_074251495.1\|479850_480237_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_052621573.1\|480233_481178_+	M56 family metallopeptidase	NA	NA	NA	NA
WP_052621571.1\|481812_482241_-	hypothetical protein	NA	NA	NA	NA
WP_086375087.1\|482233_484465_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_052621569.1\|484451_485660_-\|integrase	tyrosine-type recombinase/integrase	H7BW99	unidentified_phage	2.0e-05	28.6
486522:486536	attR	NA	NA	NA	NA

DBSCAN-SWA_2

2538015 : 2548096

Leptospira_phage(50.0%)

transposase,integrase

attL 2526536:2526551|attR 2551622:2551637

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2526536:2526551	attL	NA	NA	NA	NA
WP_005068399.1\|2538015_2540067_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_024571248.1\|2540063_2540819_-\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_005068404.1\|2541412_2542534_+\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	2.3e-11	21.0
WP_024571249.1\|2542526_2542892_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_062914938.1\|2542869_2544327_+	hypothetical protein	NA	NA	NA	NA
WP_005068421.1\|2544403_2544628_-	hypothetical protein	NA	NA	NA	NA
WP_005068424.1\|2544703_2545966_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_024571251.1\|2546045_2547290_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_005068429.1\|2547289_2548096_+\|transposase	transposase	U5N3V8	Enterobacteria_phage	2.7e-54	44.2
2551622:2551637	attR	NA	NA	NA	NA

DBSCAN-SWA_3

2833627 : 2842186

Streptococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005068898.1\|2833627_2834299_-	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	4.9e-17	31.1
WP_005057567.1\|2834412_2835336_+	peptidylprolyl isomerase	A0A1V0SCU1	Indivirus	1.1e-08	31.6
WP_005068900.1\|2835337_2836207_+	class A beta-lactamase	A0A1B0VBP7	Salmonella_phage	1.5e-55	46.0
WP_005068903.1\|2836308_2838675_-	RelA/SpoT family protein	A0A291L9W9	Bordetella_phage	1.8e-13	38.4
WP_005068905.1\|2838705_2839239_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	1.1e-14	36.4
WP_005137446.1\|2839235_2840912_-	hypothetical protein	NA	NA	NA	NA
WP_016892306.1\|2840911_2842186_-	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.5e-22	28.6

DBSCAN-SWA_4

4113771 : 4123270

Burkholderia_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005071256.1\|4113771_4114896_-	acyltransferase	A9YX16	Burkholderia_phage	2.7e-20	28.7
WP_005071257.1\|4114892_4116161_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	3.3e-06	40.3
WP_012296730.1\|4116210_4117017_-	macrocin O-methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	4.9e-56	52.6
WP_005138043.1\|4117227_4117920_-	class I SAM-dependent methyltransferase	Q98VI8	Paramecium_bursaria_Chlorella_virus	3.7e-12	30.2
WP_005138044.1\|4118152_4119286_-	acyltransferase	A9YX16	Burkholderia_phage	7.0e-16	26.2
WP_005062162.1\|4119453_4120515_-	NAD-dependent epimerase/dehydratase family protein	A0A0E3IB24	Synechococcus_phage	1.6e-17	25.8
WP_005138046.1\|4120678_4121938_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	2.1e-05	39.2
WP_079636292.1\|4122080_4122380_-	hypothetical protein	NA	NA	NA	NA
WP_005062166.1\|4122403_4123270_+	glucose-1-phosphate thymidylyltransferase RfbA	H9NC64	Sphingomonas_phage	2.8e-89	57.5

DBSCAN-SWA_5

4814159 : 4822531

Mycobacterium_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_074360113.1\|4814159_4815629_+	serine hydrolase	A0A1J0GRK9	Mycobacterium_phage	4.2e-13	28.8
WP_005082750.1\|4815756_4816569_+	DUF1906 domain-containing protein	A0A2D1GEF2	Gordonia_phage	3.1e-50	49.1
WP_005138308.1\|4816617_4817814_-	LysM peptidoglycan-binding domain-containing protein	A0A1W6JL93	Lactococcus_phage	2.6e-05	47.3
WP_005072022.1\|4818243_4819062_+	N-acetylmuramoyl-L-alanine amidase	A0A2D1GEV9	Mycobacterium_phage	3.3e-68	55.0
WP_005100873.1\|4819852_4820302_+	hypothetical protein	NA	NA	NA	NA
WP_005072025.1\|4820322_4821774_+	HAMP domain-containing histidine kinase	Q8QKV4	Ectocarpus_siliculosus_virus	2.9e-06	33.6
WP_005064635.1\|4821853_4822531_-	response regulator transcription factor	W8CYM9	Bacillus_phage	4.4e-26	31.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021122

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection