CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NZ_CP019224	Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_1, complete sequence	0 crisprs	c2c9_V-U4	1
NZ_CP019222	Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_3, complete sequence	0 crisprs	csa3,RT	0
NZ_CP019223	Mycobacterium chimaera strain CDC 2015-22-71 plasmid pDHQP20152271_2, complete sequence	0 crisprs	NA	0
NZ_CP019221	Mycobacterium chimaera strain CDC 2015-22-71, complete genome	5 crisprs	DEDDh,cas3,csa3,RT,DinG,cas4,WYL,c2c9_V-U4	7

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

13670 : 71927

Mycobacterium_phage(50.0%)

integrase,protease,transposase

attL 41635:41651|attR 74974:74990

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_007172409.1\|13670_14771_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	1.1e-05	24.5
WP_007172408.1\|14760_15330_-	hypothetical protein	NA	NA	NA	NA
WP_101930848.1\|16041_17040_+	hypothetical protein	NA	NA	NA	NA
WP_007172406.1\|17056_17350_+	hypothetical protein	NA	NA	NA	NA
WP_007172405.1\|17564_17822_-	Txe/YoeB family addiction module toxin	NA	NA	NA	NA
WP_007172404.1\|17818_18103_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_023363524.1\|18184_18946_-	hypothetical protein	NA	NA	NA	NA
WP_139315444.1\|18948_19671_-	ParA family protein	NA	NA	NA	NA
WP_023363522.1\|20367_21228_+	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_007172379.1\|21449_22970_+	DUF4226 domain-containing protein	V5UPX1	Mycobacterium_phage	6.5e-09	41.6
WP_041321561.1\|22997_23312_+	hypothetical protein	NA	NA	NA	NA
WP_007172377.1\|23387_23693_+	hypothetical protein	NA	NA	NA	NA
WP_080674297.1\|23574_25416_+	PE family protein	NA	NA	NA	NA
WP_007172375.1\|25412_25754_+	hypothetical protein	NA	NA	NA	NA
WP_007172374.1\|25866_27054_-	hypothetical protein	NA	NA	NA	NA
WP_007172373.1\|27439_27856_-	hypothetical protein	NA	NA	NA	NA
WP_080674296.1\|28016_29924_-	hypothetical protein	NA	NA	NA	NA
WP_007172369.1\|30255_30540_-	hypothetical protein	NA	NA	NA	NA
WP_023363514.1\|30502_31093_-	hypothetical protein	NA	NA	NA	NA
WP_007172368.1\|31148_31586_-	WhiB family transcriptional regulator	NA	NA	NA	NA
WP_007172367.1\|31892_32399_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_040624378.1\|32504_32756_+	type II toxin-antitoxin system ParD family antitoxin	NA	NA	NA	NA
WP_007172365.1\|32752_33046_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_139315443.1\|33263_33971_+	hypothetical protein	NA	NA	NA	NA
WP_139315442.1\|33984_34683_+	hypothetical protein	NA	NA	NA	NA
WP_007172361.1\|34797_35877_+	hypothetical protein	NA	NA	NA	NA
WP_139315441.1\|35986_36658_+	hypothetical protein	NA	NA	NA	NA
WP_139315440.1\|36781_37054_+	hypothetical protein	NA	NA	NA	NA
WP_139315439.1\|37284_37716_+	hypothetical protein	NA	NA	NA	NA
WP_074021534.1\|39147_40050_+	hypothetical protein	NA	NA	NA	NA
WP_023363510.1\|40046_40769_+	hypothetical protein	NA	NA	NA	NA
WP_040624340.1\|41089_42742_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A7P9	Microcystis_virus	8.0e-21	26.6
41635:41651	attL	NA	NA	NA	NA
WP_007172352.1\|42741_43323_-\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	1.4e-23	33.0
WP_023363507.1\|43465_44797_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_040624374.1\|45078_45495_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_007172349.1\|45497_45761_-	type II toxin-antitoxin system VapB family antitoxin	NA	NA	NA	NA
WP_142383462.1\|45973_46837_+	hypothetical protein	NA	NA	NA	NA
WP_051404593.1\|46900_48004_+	hypothetical protein	A0A1B3B1U7	Gordonia_phage	3.0e-32	59.5
WP_023363502.1\|48089_49130_+	NlpC/P60 family protein	V5UPI8	Mycobacterium_phage	1.1e-15	41.7
WP_101930849.1\|49243_50689_+	type VII secretion protein EccB	V5UN45	Mycobacterium_phage	1.3e-59	34.7
WP_007172344.1\|50685_54912_+	type VII secretion protein EccC	A0A0A0RUH6	Bacillus_phage	2.8e-17	31.7
WP_007172343.1\|55005_55302_+	PE family protein	NA	NA	NA	NA
WP_007172342.1\|55331_56486_+	PPE family protein	NA	NA	NA	NA
WP_007172341.1\|56629_56926_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_007172340.1\|56970_57255_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_007172339.1\|57333_58254_+	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_083103273.1\|58944_59847_+	hypothetical protein	NA	NA	NA	NA
WP_080674295.1\|59714_61358_+	type VII secretion integral membrane protein EccD	NA	NA	NA	NA
WP_040624331.1\|61374_63075_+\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	5.6e-70	35.2
WP_007172335.1\|63074_64667_+	type VII secretion protein EccE	NA	NA	NA	NA
WP_007172334.1\|64689_66522_+	type VII secretion AAA-ATPase EccA	V5UQM2	Mycobacterium_phage	6.3e-67	30.7
WP_007172333.1\|66529_66856_+	hypothetical protein	NA	NA	NA	NA
WP_154074434.1\|67007_67151_+	hypothetical protein	NA	NA	NA	NA
WP_007172331.1\|67184_69254_-	hypothetical protein	NA	NA	NA	NA
WP_087588785.1\|69250_70672_-	hypothetical protein	NA	NA	NA	NA
WP_080691094.1\|70754_71927_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
74974:74990	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP019221

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019221_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019221_1

513575-513663

Orphan

Consensus_repeat	Method
CCCTGGGGACCCGGCCCCGGCGG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP019221_1

>merge|NZ_CP019221|1|513575-513663|CRISPRCasFinder
CCCTGGGGGCCCGGCCCCGGCGGCCCCGGTTTGATCGTTCCGATGCCCCCGGGCGGCCCGGGCGGGCCCGGCGGTCCCGTCTCCGGCCC

>NZ_CP019221|1|1|513575-513663|CRISPRCasFinder
CCCTGGGGGCCCGGCCCCGGCGG	CCCCGGTTTGATCGTTCCGATGCCCCCGGGCGGCCCGGGCGGG
CCCGGCGGTCCCGTCTCCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019221.1\|WP_042910514.1\|520779_522252_-\|glutamate--cysteine-ligase	unknown	unknown	unknown
NZ_CP019221.1\|WP_042910516.1\|523946_524666_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP019221.1\|WP_042910513.1\|520088_520769_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP019221.1\|WP_020821423.1\|514651_515953_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	unknown	unknown	gnl\|CDD\|274583
NZ_CP019221.1\|WP_072501477.1\|506882_508802_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP019221.1\|WP_020821414.1\|503398_503821_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019221.1\|WP_008263260.1\|509087_510353_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_CP019221.1\|WP_042910515.1\|522387_523914_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_CP019221.1\|WP_008263246.1\|502780_503392_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP019221.1\|WP_042910500.1\|503833_504541_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_CP019221.1\|WP_042910508.1\|513815_514472_+\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|372884
NZ_CP019221.1\|WP_042910509.1\|515949_517263_+\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NZ_CP019221.1\|WP_042910512.1\|518934_520092_+\|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE	unknown	unknown	gnl\|CDD\|275139
NZ_CP019221.1\|WP_087139637.1\|511408_512551_+\|DUF4185-domain-containing-protein	unknown	unknown	gnl\|CDD\|379383
NZ_CP019221.1\|WP_042910510.1\|517262_517973_+\|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl\|CDD\|132483
NZ_CP019221.1\|WP_042910501.1\|504533_505763_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_CP019221.1\|WP_014378919.1\|512645_513098_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368014
NZ_CP019221.1\|WP_042910505.1\|510353_511412_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_CP019221.1\|WP_042910502.1\|505873_506866_+\|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NZ_CP019221.1\|WP_042910511.1\|517972_518938_+\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|226751

Protein	Function_ID	Function_description	E-value
NZ_CP019221.1\|WP_042910516.1\|523946_524666_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.02272e-23
NZ_CP019221.1\|WP_042910513.1\|520088_520769_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.24924e-19
NZ_CP019221.1\|WP_020821423.1\|514651_515953_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	gnl\|CDD\|274583	TIGR03444, EgtA_Cys_ligase, ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.99075e-164
NZ_CP019221.1\|WP_072501477.1\|506882_508802_-\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP019221.1\|WP_008263260.1\|509087_510353_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_CP019221.1\|WP_042910515.1\|522387_523914_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP019221.1\|WP_008263246.1\|502780_503392_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	8.42319e-112
NZ_CP019221.1\|WP_042910500.1\|503833_504541_-\|glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	9.4925e-115
NZ_CP019221.1\|WP_042910508.1\|513815_514472_+\|sensor-domain-containing-protein	gnl\|CDD\|372884	pfam14032, PknH_C, PknH-like extracellular domain. This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	2.33066e-36
NZ_CP019221.1\|WP_042910509.1\|515949_517263_+\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	7.71579e-154
NZ_CP019221.1\|WP_042910512.1\|518934_520092_+\|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE	gnl\|CDD\|275139	TIGR04343, pyridoxal-phosphate-dependent_transferase, ergothioneine biosynthesis PLP-dependent enzyme EgtE. Members of this protein family are the pyridoxal phosphate-dependent enzyme EgtE, which catalyzes the final step in the biosynthesis of ergothioneine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	7.90528e-170
NZ_CP019221.1\|WP_087139637.1\|511408_512551_+\|DUF4185-domain-containing-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	2.24511e-55
NZ_CP019221.1\|WP_042910510.1\|517262_517973_+\|ergothioneine-biosynthesis-protein-EgtC	gnl\|CDD\|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.45493e-109
NZ_CP019221.1\|WP_042910501.1\|504533_505763_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	9.11159e-80
NZ_CP019221.1\|WP_014378919.1\|512645_513098_+\|hypothetical-protein	gnl\|CDD\|368014	pfam04592, SelP_N, Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyze redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharacterized.	1.38769e-05
NZ_CP019221.1\|WP_042910505.1\|510353_511412_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_CP019221.1\|WP_042910502.1\|505873_506866_+\|DEDDh-family-exonuclease	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	0
NZ_CP019221.1\|WP_042910511.1\|517972_518938_+\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|226751	COG4301, COG4301, Uncharacterized conserved protein [Function unknown].	6.72733e-161

>NZ_CP019221.1|WP_014378919.1|512645_513098_+|hypothetical-protein
MSETPETPTVRTSTATAPAAAAAAYRAPRVFQLAAWVAIVAGIVFIVAVIFFTGFILGHRGGHHGHHHHKHHHHAMLHHRGPGGPGGPGGGTQGGPGAPTGPGATTAPASPSPVRPSGMAPGQLPASIFHSAAASHAAPGQAPSVIVLTN
>NZ_CP019221.1|WP_087139637.1|511408_512551_+|DUF4185-domain-containing-protein
MNPRVSSATRFSLLVASLLAPQWFWAAHADPPAPAPEPILQPLAPGQVLRIGPTAGTGTPTGDYGIGATDLCEFVEFPTELLQVCGDSFAGQGVGFGGWYAPVALHVDTASVDDPAGVRYTGVTGIAHPLLADPAPPDSSQLPAGVVQVNRRNYLMVTTTKDLEPQSSRLVTAEPARAGWQTIPGSKRPASYQGGSQTQISGYYDPIPTPESPSGWVYIVADSFTRRDPVVLYRATPQTFTDRSRWQGWAAGASGGWGKPPTPLWPDAVGEMCIRQIDGKAVLSYFNAATGNMEVRVAADPTALGDAPVTTVVQHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTLDELRIFVSQWDTRARVAAPYRVIQFAVNPFKPE
>NZ_CP019221.1|WP_042910505.1|510353_511412_+|aspartate-semialdehyde-dehydrogenase
MVAIGVVGATGQVGQVMRRLLDERDFPALNSGGSVRFFASARSQGRKLEFRGQEIEVEDAATADPSGLDIALFSAGKTMSLVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFTRDVANRARSLKKGIIANPNCTTMAAMPVLKVLHDEAGLQRLVVSSYQAVSGSGIAGVQELSTQARAVVDDAEQLVQDGGAVQFPAPKTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRHESRKILGIPDLAVSGTCVRVPVFTGHSLSINAEFARPLSPQRARELLDGAPGVKVVDVPTPLAAAGVDESLVGRIRQDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLAAEL
>NZ_CP019221.1|WP_008263260.1|509087_510353_+|aspartate-kinase
MALVVQKYGGSSVANADRIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLMDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAQARSFTGSQAGVITTGTHGNAKIIDVTPGRLQAALDEGRVVLVAGFQGVSQDTRDVTTLGRGGSDTTAVALAAALRADVCEIYTDVDGIFSADPRIVHNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRYNIPVHVRSSYSENPGTVVVGSIKDIAMEDPILTGVAHDRSEAKVTVVGIPDIPGYAARVFRALADADVNIDMVLQNVSKVEDGKTDITFTCSRDSGPTAVAKLDALKDEIGFSQLLYDDHVGKVSLIGAGMRSHPGVTATFCESLAEVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGGEESATVYAGTGR
>NZ_CP019221.1|WP_072501477.1|506882_508802_-|2-isopropylmalate-synthase
MTVTSNSDAFSSTRSIVKPAGPRGPGQPAWNPQRGSSMPVSRYRPFAEEVEPIRLADRTWPDRVITSAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITGGAIPDDVTIQVLTQCRPELIERTFEACLGAPQAIVHFYNSTSILQRRVVFRAEKAAVQDIATAGARKCVEEAAKYPGTRWRFEYSPESYTGTELEYAKQVCDAVGEIISPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKVDADAADTDVEDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKSDHGLALPRRLQIEFSQVVQKISEGEGGEVSPKEMWDAFSEEYLAPVWPLERVKQRVDASEEDSGVTSIAATVRINGVETEISGSGNGPLAAFVHALGDVGFDVAVLDYSEHAMSSGDDAQAAAYVEASVSIASAAEPGEAGLHPSGPVSIASAAEPGEAGRHPSGPVNGRTVWGVGIAPSITTASLRAVVSAVNRAARA
>NZ_CP019221.1|WP_042910502.1|505873_506866_+|DEDDh-family-exonuclease
MSAVCWGRPASEPDAGWAVIDVETSGFRPGQARIISLAVLGLDADGEVEQSVVSLLNPGVDPGPTHVHGLTAAMLEDQPQFADIASDVIDVLRGRTLVAHNVAFDYAFLAAEAELADIELPVDSVMCTVELARRLDLGVDNLRLETLAAHWSVTQERPHDAFDDAMVLTGVLASALKLARDGDVWLPVHPVTRRRWPNGRVTHDELRPLKVLASRMPCPYLNPGPYVGGRPLVQGMRVALAAEVGRTHEELVERILHAGLAYSEAVDRETSLVVCNDPAPEQGKGYLARKLGVPVISDATFMDCVRAVIGGTSMDEFTDTTNSDPQLALF
>NZ_CP019221.1|WP_042910501.1|504533_505763_-|Mur-ligase-family-protein
MVTTRARLALAAGASARWASRVTGRGAGAMIGGLIAMTLDRSVLRQLAAGRRTVVVTGTNGKSTTTRMTSAALATLGPVATNAEGANMDAGLVAALAANRRASLAALEVDEMHVPHVSDAVEPSVVVLLNLSRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVLMTSAAYDSPNVVWVAAGGSWSNDSVSCPRSGEVIVRERGHWFSTGADFKRPSPQWWFDDRTLHGPDGLSLPMRLTLPGAVNRGNAAQAVAAAVALGADPAKAVAAVSAVDEVAGRYRTVRVGDHEVRMLLAKNPAGWQEALSMVDKRAAGVVISVNGQVPDGEDLSWLWDVRFEHFEQTEVVAAGERGTDLAVRLGYAGVEHTLVHDTVAAIASCPPGRVEVVANYTAFLQLQRALARRG
>NZ_CP019221.1|WP_042910500.1|503833_504541_-|glutamine-amidotransferase
MADSTVRIGLVLPDVMGTYGDGGNALVLRQRLLLRGIPAEIVEITLADPVPESLDLYTLGGAEDYAQRLATRHLVKHPGLQRAAQRGAPVLAICAAVQVLGHWYETSAGQRVDGVGMLDATTSPQAARTIGELATRPLLAGLTERLTGFENHRGGTVLGPSASPLGAVVKGAGNRSGDGFDGVVQGSVIATYMHGPCLARNPQLADLLLGSVVGELPPLPMPEVDLLRRERLAAR
>NZ_CP019221.1|WP_020821414.1|503398_503821_-|hypothetical-protein
MMKIRPRLAAGAALVAAFVASSAPSHASPEVLNGRYNVLYADNDKPTAWLFVPCGSDCTLATSQDGGTFVISWEFHLADGRWTHSGTSQAPCPNGASAPVTVNYSFDAVSLAGEGQQTTTDACGPEAGRTFTRSFQLSKA
>NZ_CP019221.1|WP_008263246.1|502780_503392_+|recombination-protein-RecR
MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLAKVRDGVRFCAVCGNVSDNERCRICADPRRDGSQVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGVGPDQLRIRELLSRIGERVDDVDITEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMV
>NZ_CP019221.1|WP_042910508.1|513815_514472_+|sensor-domain-containing-protein
MTMRATHRAVLTVGFAVAGIVAPAVAAAHPSEPGVVNYAVLGKGSVGNIVGGPMGWESVFTQPGQGPWVDLPECNNWADIGLSEVYDDPDLASFNGAVTQTSANDQTHLVKQAVGVFATPDAAARAFHRVVDRTVGCSGQTTAIHLDNGSTQVWSFDGGPAGPADENWTKQEAGTDRRCFDQTRLRENVLLQAKVCQSGNAGPAVNVLAGAMQNALGQ
>NZ_CP019221.1|WP_020821423.1|514651_515953_+|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA
MTFAPITAAAPRSTGADPAPELKIAELTDSTAVAQYIADGCLVDAPLGRVGLELEAHCHDPAAPHRRPGWDEIAAVLDGLPALPGGSRITVEPGGAVELSGPPADGVLPAIEAMRRDQAVLQPAFAEAGLGLVFLGADPLRPPQRINPGARYRAMEKFFATSRSGEAGAAMMTSTASIQVNVDAGPREGWAARVRLAHALGPTMIAITANSPMLGGDFTGWVSSRQRVWGQMDSARCGPILGASGDDPGTDWGRYALKAPVMLVHTPGAEAVTQWVPFADWVDGRVLLGDRRPSVADLEYHLTTLFPPVRPRQWLEIRYLDSVPDALWPAVVFTLVALLDDPTAADAAAEAVAPVATAWDIAARLGLRDRRLYAAANACVAIAAERAPAELGDAMQRLVGLVEQGRCPGDDFADRVIEHGVAAEVSRAARGGL
>NZ_CP019221.1|WP_042910509.1|515949_517263_+|ergothioneine-biosynthesis-protein-EgtB
MTVTSCRETLADQLTRTRARTLRLVDFDDAELCRQYDPLMSPLVWDLAHIGQQEELWLLRGGDPGRPSMLSPAVEGLYDAFVHSRASRVDLPLLSPDEARAYCRTVRSAVFDALDALPDDPPGDEAAFAYAMVVSHENQHDETMLQALNLRSGPPLLCGTSMLPPARPGLAGTSVLVPGGEFVLGVDPATEPFSLDNERPGHVVDLPAFRIGRVPVTNGEWRHFIDDGGYDQPRWWSERGWRHRQAAGLTAPQFWNPDAATRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEMEWEKACAWDPSAGARRRYPWGAQEPCEALANLGGAALRPAPVGAYPAGASAYGAEQMLGDVWEWTSSPLRPWPGFVPMLYERYSQPFFDGDYRVLRGGSWAVEPGILRPSFRNWDHPYRRQIFSGVRLAWDVPKEIA
>NZ_CP019221.1|WP_042910510.1|517262_517973_+|ergothioneine-biosynthesis-protein-EgtC
MCRHLGWLGADVTVSSLVLDPPFGLRVQAYAPRRQKHCLLNADGWGVGFFDAASDGAAPRRWRSQLPLWGDVSFESVAPALRSHCVVAAVRSATVGMPIEVSATAPFTDGQWLLSHNGIVDRAVLPATSQAESVCDSAMLAAVIFERGLDALGDTIAEIAAADPRARLNILAANGSRMLATAWGDTLSILRRPDGVVLASEPYDNDSDWEDVPDRHLVEVTAGEVTMTPLDHPKGP
>NZ_CP019221.1|WP_042910511.1|517972_518938_+|L-histidine-N(alpha)-methyltransferase
MTLSLSNHLAADSAYHALRRDVFEGLQKTPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRAEAEILRARAAEIASASEADTLVELGSGTSEKTRLLLDALRTRGSLRRFVPFDVDASILSTAAAAIAQEYSGVEIKAVCGDFEEHLTEIPADGRRLFVFLGSTIGNLTPGPRADFLAALSAQMRPGDSLLLGTDLVKDLERLVRAYDDSAGVTAAFNRNVLAVVNRELDADFDVDAFAHVARWNPAEERIEMWLRADRGQRVRVGALELIVDFEAGEEMLTEVSCKFRPEKVSAELAAVGLRRTQWWTDGAGDFGLSLAVK
>NZ_CP019221.1|WP_042910512.1|518934_520092_+|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE
MTAGDSLADRWRAARPPMAGLHLDNAACSRQSVAVIDAAAQHARNESEVGGYVAAEAAAPVLDAGRVAFAALTGMTDAEVVFTTGSLHALDLLLGAWPTKHRTVACLPGEYGPNLAVMAAHGFDRRLLPTMDDGRVALDDAARALDTDRPDLVHLTAVASHSGVVQPVSMIAQLCRELGLPLVVDAAQALGQVDCAAGADATYSSSRKWIAGPRGVGMLAVRRELMESLRPRLAAPQWARASGSPTVAQQLEFGEANVAARVGFSLALGEHLAYGPAAVRARLAALGGLNRTVLADVAGWAVVEEVEEPSAITTLAPTDGADPQAVRDWLLAERRILTTFVGVQRAPLELPGPLLRISPHLDTTAEDLETFAEALIAATAATATG
>NZ_CP019221.1|WP_042910513.1|520088_520769_-|class-I-SAM-dependent-methyltransferase
MSSDQVMDWDSAYREQAHFEGPPPWNIGEPQPELAALVAAGKFRSDVLDAGCGVAELSLSLAAQGYTVVGVDLTPTAVAAATKSAQERGLTTASFVQADITSLSGYDGRFATVVDSTLFHSLPVEGRDGYLRSVHRAAAPGASYFVLVFAKGAFPSEMEPKPNEVDEDELRAAVSKYWEIDEIRPSFILSNAVNIADAPFEFPPHDRDEQGRIKMPAYLLTAHKTG
>NZ_CP019221.1|WP_042910514.1|520779_522252_-|glutamate--cysteine-ligase
MGEEVKRTTYDSAHRREYRRKVQSCLNVFETMLAQSCFDSDQPLTGMEIECNLVDADYQPAMSNRHVLDAIGDPAYQTELGAYNIEFNVPPHALPGHTGLDLEAEVRASLNEAEIKAGAADGAHIVMIGILPTLMPEHLDHDWMSESTRYAALNDSIFTARGEDLPIDIDGPEPLNWHAATIAPESACTSMQLHLQLAPETFAANWNAAQIVAGPQLALGANSPFFFSHQLWAETRIELFTQSTDTRPEELKTQGVRPRVWFGEQWITSVLDLYRENIRYFPSLLPEVSEEDPVAELAAGRTPQLSELRLHNGTVYRWNRPVYDVVDGRPHLRLENRVLPAGPTVVDMLANSSFFYGMLRSLSEADSPLWDHLDFAVAEANFLAAARHGIDARLHWPGLGEVSARDLVLDTLLPMADDGLRRWGVDPEVRDRFLGVIEGRARAGRNGATWQVSTVRALQDAGMGRAAALAEMLRRYCEYMHANEPVHTWE
>NZ_CP019221.1|WP_042910515.1|522387_523914_+|glycerol-kinase-GlpK
MAEFAEFVAAIDQGTTSTRCMIFDHEGAEVARHQLEHEQVLPQAGWVEHDPVEIWERTSSVLTSVLNRANLAPKNIAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALEGDGRGEVIRRKAGLPPATYFSGAKLQWILENVDGVRDAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFAIPRAMLPRIGPSSSPQPYGVTAETGPAGGEIAITGVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGETIVRSDNGLLTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSEALARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAGPADLRANWQEGRRWSPTWNDQQRAEGYAGWRKAVQRTLDWVSIT
>NZ_CP019221.1|WP_042910516.1|523946_524666_-|helix-turn-helix-transcriptional-regulator
MSNPFTPPEGPFGGRPGFGFGFGSGPVDRRALHEARRQARRDFREHLRDHAGGGHPGGYEGPFGFGPGFGPGFGPGFGFGPGGRRGAWRRGGPGRGKRGDVRAAILTLLSERPMHGYEMIQQIAERSNGLWKPSPGSVYPTLQLLDDEGLITASESAGSKKLFELTEQGRGAAEKIETPPWDEITEGADPGHMSLRAAVGQLFGAVGQSAHTASAEQQQRIVDILNNARREIYGILGED

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Crispr_ID: NZ_CP019221_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019221_2

1805854-1805932

Orphan

Consensus_repeat	Method
TCCGCCGCGGAGGTCCGTGGGCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019221_2

>merge|NZ_CP019221|2|1805854-1805932|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCCGCTGCGCCTCATCGCTTCGCATTGCATCGTCCGCCGCGGAGGTCCGTGGCCGCC

>NZ_CP019221|2|2|1805854-1805932|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCC	GCTGCGCCTCATCGCTTCGCATTGCATCG
TCCGCCGCGGAGGTCCGTGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019221.1\|WP_008254722.1\|1794488_1795046_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP019221.1\|WP_020821948.1\|1795054_1795585_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP019221.1\|WP_041320846.1\|1807734_1808175_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP019221.1\|WP_020821961.1\|1813480_1814347_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_CP019221.1\|WP_020821960.1\|1812052_1812466_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP019221.1\|WP_042911045.1\|1803111_1804947_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|182342
NZ_CP019221.1\|WP_042911043.1\|1800211_1801456_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP019221.1\|WP_041320848.1\|1811116_1811602_+\|RrF2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
NZ_CP019221.1\|WP_020821956.1\|1807164_1807656_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NZ_CP019221.1\|WP_051445846.1\|1801442_1803077_-\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP019221.1\|WP_042911042.1\|1797494_1800116_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NZ_CP019221.1\|WP_042911040.1\|1795679_1796183_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NZ_CP019221.1\|WP_020821958.1\|1808287_1809217_+\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_CP019221.1\|WP_008254752.1\|1809216_1811058_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
NZ_CP019221.1\|WP_009955270.1\|1805974_1806952_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP019221.1\|WP_008254755.1\|1811619_1812009_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP019221.1\|WP_042911092.1\|1792540_1794307_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP019221.1\|WP_042911041.1\|1796346_1797498_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NZ_CP019221.1\|WP_051197806.1\|1804943_1805852_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP019221.1\|WP_008254760.1\|1812532_1813411_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009

Protein	Function_ID	Function_description	E-value
NZ_CP019221.1\|WP_008254722.1\|1794488_1795046_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	4.57725e-31
NZ_CP019221.1\|WP_020821948.1\|1795054_1795585_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	3.73752e-31
NZ_CP019221.1\|WP_041320846.1\|1807734_1808175_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.31203e-31
NZ_CP019221.1\|WP_020821961.1\|1813480_1814347_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.00297791
NZ_CP019221.1\|WP_020821960.1\|1812052_1812466_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	3.94653e-12
NZ_CP019221.1\|WP_042911045.1\|1803111_1804947_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|182342	PRK10261, PRK10261, glutathione transporter ATP-binding protein; Provisional.	7.51722e-170
NZ_CP019221.1\|WP_042911043.1\|1800211_1801456_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.0976e-11
NZ_CP019221.1\|WP_041320848.1\|1811116_1811602_+\|RrF2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.50922e-49
NZ_CP019221.1\|WP_020821956.1\|1807164_1807656_+\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.82269e-65
NZ_CP019221.1\|WP_051445846.1\|1801442_1803077_-\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.69623e-158
NZ_CP019221.1\|WP_042911042.1\|1797494_1800116_+\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	7.45274e-09
NZ_CP019221.1\|WP_042911040.1\|1795679_1796183_-\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.15779e-45
NZ_CP019221.1\|WP_020821958.1\|1808287_1809217_+\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP019221.1\|WP_008254752.1\|1809216_1811058_+\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_CP019221.1\|WP_009955270.1\|1805974_1806952_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.50326e-99
NZ_CP019221.1\|WP_008254755.1\|1811619_1812009_-\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	4.24427e-67
NZ_CP019221.1\|WP_042911092.1\|1792540_1794307_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.70912e-159
NZ_CP019221.1\|WP_042911041.1\|1796346_1797498_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	6.12647e-63
NZ_CP019221.1\|WP_051197806.1\|1804943_1805852_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.7458e-85
NZ_CP019221.1\|WP_008254760.1\|1812532_1813411_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.86964e-30

>NZ_CP019221.1|WP_051197806.1|1804943_1805852_-|ABC-transporter-permease
MDGAHGFSSHDAADFTSRRTLVLRRFARNRFAVASLTLLVLLFVGCYTLPAVLPFSYEDLDFTALLQPPSARHWLGTNALGQDLLAQILRGMQKSMLIGICVAVISTGIAATVGSVSGYFGGWRDRVLMWLVDLLLVVPSFILIAIVTPRTKDSANIVMLVLLLAGFGWMVSSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVASAILAETGLSFLGFGIQPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVLILVCANLTGDGLRDALDPGSTPVRGGAR
>NZ_CP019221.1|WP_042911045.1|1803111_1804947_-|ABC-transporter-ATP-binding-protein
MSPLLEVTDLAVTFATGGDPVTAVRGVSYRVEPGEVVAMVGESGSGKSVSAMAVVGLLPEYARVRGSVRLHDTELLGLDDDAMSRFRGKTVGMVFQDPMSALTPVYTVGDQIAEAIEIHQPRVGRRAARHRAVELLELVGIAQPERRARAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAEVHDLYRDRRMPYTVGLLGSVPRLDAAQGSRLVPIPGAPPSLAGLDPGCPFAPRCPLAIDECRLEEPELLPVGADHRAACIRTDQVGGRSAADIYGVSTTAVSARPDGSSVVVRVRDLTKTYRLTKGVLRRRAGEVRAVDGVSFELREGRTLGIVGESGSGKSTTLHEILELTGPQSGSIEVLGTDVTTLSSASRRSLRRDIQVVFQDPVASLDPRLPVFELLAEPLRANGFDKGRTNARVAELLEIVGLRRADAIRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQALFGLSYLFVSHDLSVIKHLAHEVVVMRSGTVVERGDSRQVFDNPQHEYTRQLLNAVPRPDPGARG
>NZ_CP019221.1|WP_051445846.1|1801442_1803077_-|ABC-transporter-family-substrate-binding-protein
MALALSGCSPAINLIPETGQNARIGTSSDINPRDPATLRDGGDLRLALTAFPPNFNILHIDGNSAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTGTAPQVVTYTINPKAVWSDGTPITWEDIASQVHALSGADKNFEIAGPSGAERVASVTRGVDDRQAVMTFAKPYAEWRGMFAGNGMLLPKSMTATPEAFNKGQLDGPGPSAGPFIATSLDRTTLRIVLSRNPKWWGPRPRLDNITYLVLDDAARLPALQNNTIDATGVGTIDQLTIAQRTKGITIRRAPAPAWSHITFNGAPGSILADKALRVAVSRGIDRQTIAKVVQYGLTSDPVALGNHIYVAGQKGYQDNSAVVPYDPAAAKRELDALGWKQVGQFREKDGRPLIIRDLFYDAQGSRQFAQIAQHSLAQIGVKLELVARAGSGFFTNYINVGAFDLAQFGWLGDAFPLSSLTQIYKSDGESNFGKIGSPQIDAAIERTLEELDPDRARALANELDRLIWAEGFSLPLTQSPGDVAVRSTLANFGAAGLGDLDYTAIGFTRS
>NZ_CP019221.1|WP_042911043.1|1800211_1801456_+|alpha/beta-fold-hydrolase
MTMNAKRSRVQQKLAELPGVRAVRRPISPHSADEFDLYYVRTGRKSRHPLVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRHDDSGADLPPQSMTVNQVVDDVAAVLDDAHADSADIYGASYGTYIAAGVGVRHPERVHAMVLDSPLLSRHDIVIVRRAIRRLLLRGDSPETAALAPKMRKLVDAGVMTPAATHVVATIYGYGGADLLERQLDLLLQRRKLLWWTLSRFTTLSNLPFRYEEDLVSRIAFRELDYAAEPDGLPLDPAVAESEARTHRVTFEDEPYDLPTEMPNFNWPTAVISGGRDLITPPAVAERVASLLPDAVLLSLPSMAHSALDFREPVALAAADAVGRGDLKGLAAQASALDALPPRPEVRLLWKLIETAAAAEGALPVPTRLLRRLSCA
>NZ_CP019221.1|WP_042911042.1|1797494_1800116_+|AAA-family-ATPase
MKLHRLILTNYRGISHREIEFPDHGVVVVCGANEIGKSSMIEALDLLLESRDRSTKKEVKQVKPTHSDVGSEVSAEISCGPYRFVYRKRFHKRCETELTIITPCREQLTGDEAHERVRAMLAETVDSDLWHAQRVLQSTSTAAVDLSGCDALSRALDVAAGDSGGLCGTEPLLIERIDTEYARYFTPTGRPTGQWAAAIARLADAEAAVAECAAAVAEVDDRVARHAVLTEQVADFSQRRIAAGPRVAAAREAADRIAELTAQQREAQLVAAAAAATSAAATAAHTGRLQLLAEIDARAGAVAETEAQAHQAACAHASARAEAEACDATLQRATQVLADLQCRVDAARRGVDRLADLEEVDRLSTRLAKVDAIERDRERICAELSTIAVTEELLRRIEDACAAVDRIGDHLASTSAAIEFTAAADIHLVVGGERISLSAGQSWSITAAGSTVVEVSDVLTARVTPGATTLDIHAKHAAAQQEMTAALAAAEVADLAAARSADQRRRELVSTRDQLGATLAGLCGDEQIDEMRSRLARLRAQHPAEPAPGATDIGAARAELDVAQQGHAAASTDCEAHRQAATAAAAALAELSTRATVLQNTLEAQRAELQAAAGRLAAERASVSDEELAASADSALRAEQAADQRVGELAAALAAASPDAVAAELAEATKEAESLRERYEEAARALREITIELSVFGSEGRQGKLDTAETEREHAATEHSQIGARARAAKLLRSVMTRHRDTTRRRYVEPYRAELQRLGRPVFGPSFEVDIDSDLCIRSRTLNGITVPYESLSGGAKEQLGILARLAGAALVAKEDAVPVVVDDALGFTDPDRLAKMGQLFDSVGTHGQVIVLTCSPDRYDGVRGAHRIDLTA
>NZ_CP019221.1|WP_042911041.1|1796346_1797498_+|exonuclease-SbcCD-subunit-D
MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLGALAAEVDAEFVVVSGDVFEHNQLPPTVIGQSLEAMRAIGIPVYLLPGNHDPLDASSVYTSALFAAERPDNVVVLDRAGVHQVRPGLEIVAAPWRSKVPTTDLVADVLDGLPAAAGIRILVAHGGVDVLDPDKDKPSLIRLATLDDALSRGAVHYVALGDKHSLTQVGDSGRVWYSGSPEVTNFDDVESDPGHVLVVDVDETDPRGAVSVTARDVGRWRFVTLHRQVDTSRDIADLDVNLDLMTDKDRTVVRLALTGSLTVTDRAALDACLDKYARLFAWLGLWERHTDLAVIPADGEFSDLGIGGFAAAAVEELVATAREEDSATAVDAQAALALLLRLADRGAA
>NZ_CP019221.1|WP_042911040.1|1795679_1796183_-|histidine-phosphatase-family-protein
MTAERTLLLMRHAKSDYPAGVADHDRPLAPRGVRQAGLAGDWLRAHVPPVDRVLCSTATRTRETLRNTRIDAPVRYSERLYASTPGTLIDEINTVDDGIGTLLVIGHEPTMSALALGLGRAGGTDDAAAERISAKFPTSAIAVLAVPCAWKELELGGASLIDFVVPR
>NZ_CP019221.1|WP_020821948.1|1795054_1795585_+|DUF3558-domain-containing-protein
MRAAAVLLLAALLVLTGCSRSIGGNAVKAGGNVPRNNNSQQQYPNLLKECEVLTSDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGSLSNERKVAEFLKYKIESRPIAGIDSIVMRPDDANGACGVASDAAGVVGWWVNPQAPGIDACGQAIKLMELTLATNS
>NZ_CP019221.1|WP_008254722.1|1794488_1795046_+|DUF3558-domain-containing-protein
MRRSARALALVASALTILIPAVAACSDSGGNKPGATASSTPQKGQGNHGPMFPQCGGISDQTVAELTRVTGLINTARNSVGCQWLAGGGILGPHFSFSWYRGSPIGRERKTEELSRASVDDININGHGGFIAVGNEPNLGDSLCEVGIQFQDDFIEWSISFSQKPFPPPCDIAKELARQSIANSK
>NZ_CP019221.1|WP_042911092.1|1792540_1794307_-|ABC-transporter-ATP-binding-protein
MLLALLRQYIQPYRRLVAVLMVLQLISNLASLYLPTVNAAIIDEGVAKGDTAAIVRLGIVMLGATGLQVLCSVGAVYFGSRTGMGFGRDLRAAVFEHVLTFSERESARFGAPTLLTRSTNDVRQIQYLVQITATVLVTAPIMCLGGIVMALRQEAALTWLLLVSVPVMAVTNYWVMSHMLPLFRRMQGLIDGINRVMRDQLAGVRVVRAFAREGFERDRFARANAALSNTALTAGNWQALMLPVTTLTINVSSVALIWFGGLRIDRGQMQVGSLTAFLAYFTQILMAVLMATMTLVVLPRASVCAERITEVLTTRPAVTDPPGPASPPGKITGVVRLDGATFTYPGADRPVLQDISFIARPGTTTAIVGSTGSGKSTLISLICRLYDVTGGTVLVDDIDVRDYHTERLWSAIGLVPQRGYLFSGTIADNLRYGAAPGHDITGDEMWEALRVADADGFVRAHPDGLQMRVAQGGINFSGGQRQRLAIARAVIRRPAVYLFDDSFGALDVHTGARVRAALKPISKEATVIVVTQRVSTAAQADQVIVVDGGRLVGAGTHESLLADSATYAEFADSQAVGALPSGHVGGAQ
>NZ_CP019221.1|WP_009955270.1|1805974_1806952_-|ABC-transporter-permease
MTRFLARRLLNYVVLLALASFLTFCLTSVAFKPLDSLLQRNPRPPQAVIDAKAHALGLDEAIPIRYAHWASHAVRGDFGKTVTGQPVGESLWRRVGVTLRLLVIGSLVGTVAGIAAGAWGAIRQYRLSDRVVTMVALLVLSTPTFVIANLLILAALRVNWAVGLQIFDYTGETSPGVSGGAGAHFFDRLRHLVLPSLTLALAAAAGYSRYQRNAMLDVLGQDFIRTARAKGLTRRRALVKHGLRTALIPLATLFAYGVAGLVTGAVFVEKIFGWHGMGEWLVQGIATQDTNIVAAITVFSGAVVLLAGLLSDVFYAALDPRVRVS
>NZ_CP019221.1|WP_020821956.1|1807164_1807656_+|carbonic-anhydrase
MTVTDDLLANNAEYAKTFNGPLPMPPGKHVAVVACMDARLDVYRLLGLNEGEAHVIRNAGGVVTDDVIRSLAISQRLLGTREIILIHHTDCGMLTFTDDDFKRSIQEETGVKPPWAAEAFPDVAEDVRQSLRRIEGSPFVTKHVSARGFFFDVATGKLNEVTL
>NZ_CP019221.1|WP_041320846.1|1807734_1808175_-|PaaI-family-thioesterase
MTSHSGPSRPPAPSGRDVIAQFLPQSPFVVKLGIVADRLEEDEVRLRLPWDPSNVTIGDMVHGGAIATLADLTVMAAAWCGVPAPPELRGVTVSMALDYMAPARATDVIGIGRVLRRGRSLVNCEAEIVDSGGTLVAKALATYKVG
>NZ_CP019221.1|WP_020821958.1|1808287_1809217_+|sulfate-adenylyltransferase-subunit-CysD
MTSDLKTAPAVGQYELSHLRSLEAEAIHIIREVAAEFERPVLLFSGGKDSIVMLHLALRAFRPGRLPFPVMHVDTGHNFDEVIATRDELVKEHGVRLVVASVQEDIDAGRVVEPRQGRNPIQTVTLLRAIRENKFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAENIALPSIYYAHRRKVFRRDGMLLAVDKNMQPNADEPVFEATVRFRTVGDVTCTGCVESQAATVEEVIAETAVSRLTERGATRADDRISEAGMEDRKRQGYF
>NZ_CP019221.1|WP_008254752.1|1809216_1811058_+|adenylyl-sulfate-kinase
MATLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDKEKFEAIRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNMVDVRFPVQYVIRPHTREHQDHRSYAGTVASGVMRAGDEVVVLPVGKHTRITAIEGPNGPVEEAFPPMAVSVTLADEIDISRGDLIARTHNQPRVAQEFDATVCWMADGAALEPGRDYVIKHTTRTTHAKVTALDYRLDVNTLHRDKSATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKPSAIAQARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGSLAYVLDGDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFEFIEVFCDTPIDECEKRDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLTPDGTIEEQAQRVLDLLESRG
>NZ_CP019221.1|WP_041320848.1|1811116_1811602_+|RrF2-family-transcriptional-regulator
MRMSAKAEYAVRAMIQLATVPDGTLVKTDDLAQAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARSGSDISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRSVLEQTTLADVATGGLPKHVAQLADDYRKQESQRHGSARTGD
>NZ_CP019221.1|WP_008254755.1|1811619_1812009_-|VOC-family-protein
MSISFNHTIVASRDKRESAEFLTELFGLPSPKPFGHFMVVELEHGATLDYADAPDGADIPRQHYAFLVSEQEFDTIYDKIRARGMQHWADPGATRPGEINHNDGGRGVYFTDPSGHAMEILTRPYGSGG
>NZ_CP019221.1|WP_020821960.1|1812052_1812466_-|VOC-family-protein
MDFTSTSIAHVRLTVTDIERSRQFYESVFGWPVLLEVPDNADEATRNQLSFLFGGVIYDLGGTLLGLRPVAAGRFDENRVGLDHIAFRLTTRDELDSAAAHLDELGVAHEPIKDIGPSYILEFRDPDNIALELTAPK
>NZ_CP019221.1|WP_008254760.1|1812532_1813411_+|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDATVLETWARTIDEGPFSSLCWGERIAFDNPDNLTLLGALAAWTDRVRLLTTVIVPQLHDPVMLAKGLATGDMLSGGRLTVGIGVGGRHEDYHAVGADPATQTMRGMAERVAVMKRVWAGEKTTDSVRPVGPAPVQPGGPPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQNELFDVTRDAWARAGKPKPHLITSFWFAFGSPEESRAQVHRHLRRYMNWIPAEYVDAMAPMTGWAGSEDELLDVLRRFEEIGTDEVQLIPTSSDVDQLRRAAEVAGRL
>NZ_CP019221.1|WP_020821961.1|1813480_1814347_+|tetratricopeptide-repeat-protein
MTQQELPAPLAEMTGLMARCANNGDFAGAALQANELVTLCRATLGERDPNVLELKVALATVQLRAGEDADVYADLDALIPDLVAVLGPDHLSTLTARHLFAGRQQPPVSSLSEWSQLVADEQRILGPDHESTLMARERVAEKRWETGDFAGAMTEGQHVLAARRRVLGDDHADTLGTRLMLAIWRGRAGDIPGAITELEWLIGELRDKLGSGHVHLLMARHMFTLWAPKRAGVTDGVTAWEALVEEEARVLGDEHPVTIAARQELAGWCARHRARAGEPDTPVDWSAS

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Crispr_ID: NZ_CP019221_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019221_3

2786260-2786373

Orphan

Consensus_repeat	Method
GGTGTGATCGCGGCTTCGCCGCTCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019221_3

>merge|NZ_CP019221|3|2786260-2786373|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACA

>NZ_CP019221|3|3|2786260-2786373|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACA	TGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCG
GGTGTGATCGCGGCTTCGCCGCTCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019221.1\|WP_054585461.1\|2782865_2783510_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|224712
NZ_CP019221.1\|WP_003878110.1\|2783675_2783966_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP019221.1\|WP_054585469.1\|2782022_2782799_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402
NZ_CP019221.1\|WP_054585464.1\|2788568_2789669_-\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NZ_CP019221.1\|WP_008256146.1\|2780050_2781208_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NZ_CP019221.1\|WP_008256210.1\|2789665_2789935_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019221.1\|WP_014384578.1\|2789931_2790954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP019221.1\|WP_054585459.1\|2778833_2779784_+\|cell-division-protein-FtsQ/DivIB	unknown	unknown	gnl\|CDD\|224505
NZ_CP019221.1\|WP_054585462.1\|2785120_2785459_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|376764
NZ_CP019221.1\|WP_085976493.1\|2793761_2794529_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|224139
NZ_CP019221.1\|WP_008256225.1\|2792897_2793686_+\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NZ_CP019221.1\|WP_008256222.1\|2792299_2792887_+\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|213872
NZ_CP019221.1\|WP_008256153.1\|2784229_2785027_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226127
NZ_CP019221.1\|WP_054585458.1\|2777355_2778837_+\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_CP019221.1\|WP_072501282.1\|2781270_2782017_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|224413
NZ_CP019221.1\|WP_054585463.1\|2785462_2786137_-\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|224837
NZ_CP019221.1\|WP_014384579.1\|2791108_2791411_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019221.1\|WP_054585465.1\|2791485_2792238_+\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NZ_CP019221.1\|WP_008256205.1\|2788035_2788566_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|224793
NZ_CP019221.1\|WP_008256203.1\|2786643_2787999_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163

Protein	Function_ID	Function_description	E-value
NZ_CP019221.1\|WP_054585461.1\|2782865_2783510_+\|cell-division-protein-SepF	gnl\|CDD\|224712	COG1799, COG1799, Uncharacterized protein conserved in bacteria [Function unknown].	3.81459e-45
NZ_CP019221.1\|WP_003878110.1\|2783675_2783966_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	1.05966e-07
NZ_CP019221.1\|WP_054585469.1\|2782022_2782799_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	3.06984e-80
NZ_CP019221.1\|WP_054585464.1\|2788568_2789669_-\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	1.28163e-180
NZ_CP019221.1\|WP_008256146.1\|2780050_2781208_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NZ_CP019221.1\|WP_014384578.1\|2789931_2790954_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00934122
NZ_CP019221.1\|WP_054585459.1\|2778833_2779784_+\|cell-division-protein-FtsQ/DivIB	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	1.98809e-51
NZ_CP019221.1\|WP_054585462.1\|2785120_2785459_+\|phage-holin-family-protein	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	0.00355035
NZ_CP019221.1\|WP_085976493.1\|2793761_2794529_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|224139	COG1218, CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism].	1.26252e-75
NZ_CP019221.1\|WP_008256225.1\|2792897_2793686_+\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	2.09061e-125
NZ_CP019221.1\|WP_008256222.1\|2792299_2792887_+\|DUF3090-domain-containing-protein	gnl\|CDD\|213872	TIGR03847, TIGR03847, conserved hypothetical protein. The conserved hypothetical protein described here occurs as part of the trio of uncharacterized proteins common in the Actinobacteria.	2.70755e-88
NZ_CP019221.1\|WP_008256153.1\|2784229_2785027_+\|DivIVA-domain-containing-protein	gnl\|CDD\|226127	COG3599, DivIVA, Cell division initiation protein [Cell division and chromosome partitioning].	5.87672e-33
NZ_CP019221.1\|WP_054585458.1\|2777355_2778837_+\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_CP019221.1\|WP_072501282.1\|2781270_2782017_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|224413	COG1496, yfiH, Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism].	6.6978e-96
NZ_CP019221.1\|WP_054585463.1\|2785462_2786137_-\|phosphoribosyltransferase	gnl\|CDD\|224837	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only].	7.58023e-93
NZ_CP019221.1\|WP_054585465.1\|2791485_2792238_+\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	9.41418e-122
NZ_CP019221.1\|WP_008256205.1\|2788035_2788566_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|224793	COG1881, COG1881, Phospholipid-binding protein [General function prediction only].	5.12793e-60
NZ_CP019221.1\|WP_008256203.1\|2786643_2787999_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0

>NZ_CP019221.1|WP_054585463.1|2785462_2786137_-|phosphoribosyltransferase
MNRPNGFLRRTATRNFRDRREAGRALAEELTSYRGRDLLVFGLARGGVPVAWEIAAALGAPLDVFLVRKLGVPNWSELAMGALASGGGLVMNDDVVASLRVTDEQVREVIDSETTELLRREHAYRGDRPIADPRDRVVILADDGIATGASMLAAVRAVRAAGPESITVAVPVGPESACRDLAREADDVVCATMPPGFEAVGQVYDDFHQVSDDEVRELLATPTA
>NZ_CP019221.1|WP_054585462.1|2785120_2785459_+|phage-holin-family-protein
MLVIALVLALIGLVALVFAVVTSNELVAWLCIAASVVGVVLLILDALRERQHREPGGAEDQDADEARPDEDDYVDYPEEAAAEGEAEAVADGTEPTAESSVAAEGRGDESAK
>NZ_CP019221.1|WP_008256153.1|2784229_2785027_+|DivIVA-domain-containing-protein
MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVEAELTRLIEENSDLRQRIEELDQELASGGGAAAPAAAAAPTQAIPVREPEPEPVKAAAAPAAAVNNEEQAMKAARVLSLAQDTADRLTSTAQAESEKMLSDARANADQILSEARSTAETTVAEARQRADAMLADAQTRSETQLRQAQEKADALQADAERKHSEIMGTINQQRTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSADAGGFDQFNRGNN
>NZ_CP019221.1|WP_003878110.1|2783675_2783966_+|YggT-family-protein
MVLFFQILGFALFIFWLLLIARVVVEFIRSFSRDWHPTGITVVVLEIIMSITDPPVKLLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAA
>NZ_CP019221.1|WP_054585461.1|2782865_2783510_+|cell-division-protein-SepF
MSTLHKVKAYFGMAPMDDYEDEYYDDRAPSRGFPRPRFDDGYGRYDGDDYDDPRREPADYPPPGGYRGGYAEEPRYGSVHPREFDRGERGGPRFGSWLRNSTRGALAMDPRRMAMMFEEGHPLSKITTLRPKDYSEARTIGERFRDGTPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
>NZ_CP019221.1|WP_054585469.1|2782022_2782799_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MAVEISNGGDRESELTHALAAVRSRLAAAAEAAGRNVAEIEVLPITKFFPATDVVTLSRLGCRAVGESRDQEATAKVAEVTRLLAAPERADVGNPRWHMVGHIQRNKARSVAGWAHTAHSVDSAHLVTALDRGVAAALAEGRRTDPMRIYVQVSLDGDESRGGVDISRPGAVDQMCDQVEGSTNLALAGLMAIPPLDSDPDEAFDRLQSEHRRVLESHRNAVGLSAGMSNDFEIAVKHGSTCVRVGTALLGRRRLPSP
>NZ_CP019221.1|WP_072501282.1|2781270_2782017_+|peptidoglycan-editing-factor-PgeF
MQPGGQRLPDTGHVSVRIRRVTTTRAGGVSKPPFDTFNLGDHVGDDPAAVAENRSRLAAGIGLRAGRMVWMNQVHGDRVEVVDGPREAAVDDTDALVTRTARLALAVVTADCVPVLMADARAGVAAAVHAGRVGAQRGVVARTVEAMLELGARPHDISALLGPAVSGLNYEVPAAMADEVEAALPGSRTTTGAGTPGLDLRAGIACQLQGLGVTAIDIDPRCTVGDPTLFSHRRDAPTGRLASLVWME
>NZ_CP019221.1|WP_008256146.1|2780050_2781208_+|cell-division-protein-FtsZ
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRRAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRGNQAESGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHQDANIIFGTVIDDSLGDEVRVTVIAAGFDATGPGRKPVIGGNADKEEKVGAHRIESAKAGKLTSTLFEPVDAVSVPVHTNGSTLNIGGDDDDVDVPPFMRR
>NZ_CP019221.1|WP_054585459.1|2778833_2779784_+|cell-division-protein-FtsQ/DivIB
MTQPPPEPTVGDQADNPVPDDAATEPLVTGAGDQAAADQTPDPAEVEGPRRRARRERAERRAAQARATAIEEARREAKRRATGRPVHEPKPVARGVVRGLKMLLVTILLVIVGVGLALVLYFTPAMSARNIVVIGTGAVTREEVLDAARVRPGTPLLQINTSQVADRVAAIRRVASARVQRQYPSALRITIVERVPVAVKDFPDGPHLFDRDGVDFATGPPPPALPYLDVADPGPNDPATKAALQVLTALRPEVSDQVGRVAAPSVASITLTLGDGRVVIWGTTDRTDEKAEKLSALLTQPGKVYDVSSPDLPTVK
>NZ_CP019221.1|WP_054585458.1|2777355_2778837_+|UDP-N-acetylmuramate--L-alanine-ligase
MTTEQLPPELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGIHALRARGAQITIGHDAASLDLLPGGATAVITTHAAIPKTNPELVEARRRGIPVILRPAVLAKLMNGRTTLMVTGTHGKTTTTSMLIVALQHCGRDPSFAVGGEMGEAGTNAHHGSGDCFVAEADESDGSLLEYTPNVAVVTNIETDHLDFYGSADAYVGVFDSFVDRLAPGGALVVCVDDPGAAALARRTAELGIRVLRYGSGASLSGEPLAATLLSWQQQGTEAVAQIQLAPDLDPEQHPRVMRLSVPGRHMALNAMGALLAALEIGAPADAVLDGLAGFEGVRRRFELVGTAGNGQPVRVFDDYAHHPTEIVATLAAVRTLLEQSGDGRSIAVFQPHLYSRTKAFAEEFGHALDAADEVFVLDVYGAREQPLAGVSGASVAEHVSVPVRYLPNFSAAAEQVAAVAGPGDVIVTMGAGDVTLLGPEIVTALRVRANRGAPGALR
>NZ_CP019221.1|WP_008256203.1|2786643_2787999_+|M20/M25/M40-family-metallo-hydrolase
MTIQSGATEEPTNPSDDVVEVVSKLIRFDTTNTGEPETTKGEAECAQWVAEQLAEVGYAPQYVESGAPGRGNVFVRLPGADPSRGGLLIHGHLDVVPAEPTEWSVHPFSGAVKDGFVWGRGAIDMKDMVGMMIVVARQLKRAGIVPPRDLVFAFIADEEHGGTFGAQWLVDNRPDLFDGVTEAIGEVGGFSLTVPRRDGGERRLYLIETAEKGLSWMRLTARGPAGHGSMVHDQNAVTAVAEAVARLGRHQFPLVLTDTVAQFLAAVSEETGLTFDTESGDLRGAVEKLGPMARMLKAVLHDTANPTMLKAGYKANVVPAIAEAVVDCRILPGRKEAFEAEIDELLGPDVTREWIKDFSSYQTSFDGDLVDAMNAAVLALDPDARTVPYMLSGGTDAKSFARLGIRCFGFSPLRLPPDLDFTALFHGVDERVPIDALRFGTDVLTHFLTHC
>NZ_CP019221.1|WP_008256205.1|2788035_2788566_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSTAPDPYASLPKLPTFTLTSQSVTDGQPLAKPQVSGIMGAGGEDVSPQLSWSGFPDGTRSFAVTVYDPDAPTASGFWHWAVANLPADVTELAEGAGDGSNLPGDALTLVNDAGLRRYLGAAPPAGHGPHRYYIAVHAVDTDKLDLPEDASPAFLGFNLFQHAIARAVIHATYEQK
>NZ_CP019221.1|WP_054585464.1|2788568_2789669_-|quinone-dependent-dihydroorotate-dehydrogenase
MTPDRPRAGGHRLYGLLRQLFFVIPPERIHTLVFGFLRGVTAVAWARRALRRLLGPTDPALASTVFGVRFPGPLGLAAGFDKDGLGVLTWGALGFGHAEVGTVTAHPQPGNPAPRMFRLPADRALLNRMGFNNLGAGALAMRLARQRPEVPIGVNIGKTKATPADQAVDDYRASARLVGPLASYLVVNVSSPNTPGLRDLQAVDSLRPILSAVLAETTTPVLVKIAPDLSDADVDAIADLAVELGLAGIVATNTTISRQGLRTPGVDELGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIENADDAWERITAGASLLQGYTGFIYGGGLWAKQIHDGVARRLHDGGFASLSEAVGAAARG
>NZ_CP019221.1|WP_008256210.1|2789665_2789935_-|hypothetical-protein
MTAARHSRLPAGWDTEMSDEYEWVPLRLPPEVTRVSASTRLSIEAEYRGWELTRVRLYNDGSRRVLLRRKKSRLDGTGYEGRRPDQPQL
>NZ_CP019221.1|WP_014384578.1|2789931_2790954_-|hypothetical-protein
MLSLAVLLGATVGCSSNPLAGAPRTIEPAAAAVSPPPSQSPAGAVRPLPAHAAAAVFDAGTRRLAVLAPGSDPAAPGSITVFGEAQAPPRVVDLPGPASALTDDGQGTAYLAARGGYFAVDLSTGHTAQVSVSDAAQTEFTAVARRADGRLVLGSADGAVYTLASPKPGAVSAASVASRNKVFARVDCLVTQGDTTVVLDRGQTSVTTIDADGHVQQALRAGRGATTMAADALGRVLVADTRGGQLLVYGVDPLILRQAYPVSQAPYGLAGSRALAWVSQTVSNIVIGYDLSTGIPVEKVRYPTVQQPNSLAFDEASDTLYVVSGSGAGVQVIDHAAGRR
>NZ_CP019221.1|WP_014384579.1|2791108_2791411_+|hypothetical-protein
MAVTADRHMTQEEFAVEDMSTGIFASGYGQVGDGRSFSFHIENRSLVVEVYRPRLAGPVPQADEVVATAVRSLVDIDLTDERSLSAAVRDSVAHAEPVSR
>NZ_CP019221.1|WP_054585465.1|2791485_2792238_+|MSMEG_4193-family-putative-phosphomutase
MTVILLRHGRSSSNTAGILAGRSEGVDLDDKGREQAAALIDRIGDLPIRELITSPLLRCRRTLEPLADALCLAPLVEDRLAEVDYGEWTGRKIGELVSEPLWKVVQAHPSAAVFPGGEGLAQVQARAVAAVREHDRRLASEHGGDALWVACTHGDVIKAVIADAYGIHLDGFQRVTADPASVSVIRYTELRPFVLHVNHTGARLSAALRAGPQPKEEATAETDGQPNGEAQAPPAAGVPSSDAVVGGSTD
>NZ_CP019221.1|WP_008256222.1|2792299_2792887_+|DUF3090-domain-containing-protein
MSRAIHVFRTPDRFVAGTVGQPGNRTFYIQAVHDARVVSVILEKQQVAVLAERIGALLLEVNRRFGTPVPPEPAEVEDLKPLITPVDAEFRVGTMGLGWDSEAQTVVVELLAVTDAEFDASVVLDDTEEGPDAVRVFLTPESARQFASRSNRVISAGRPPCPLCDEPLDPEGHICARANGYRRNALLGSDDDPEV
>NZ_CP019221.1|WP_008256225.1|2792897_2793686_+|SCO1664-family-protein
MLRNGELTVIGRIRSASNATFLCESTLDERAVHCVYKPVAGEAPLWDFPDGTLAGRERAAYLVSAQLGWNIVPYTIIRHGPAGPGMLQQWVQQPGDTVDTEPRPGPDLVDLFPAGKAQPGYLPVLRAYDYAGDEVVLMHADDIRLWRMAVFDVLVNNADRKGGHVLRDLDGHIFGVDHGVCLHVEDKLRTVLWGWAGKPIDSQTCKAVAGLAEALTGSFGDELAEHITSAEIAALRMRAHALLDNPVMPGPNRHRPIPWPAF
>NZ_CP019221.1|WP_085976493.1|2793761_2794529_+|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MTDAALAADLAAEAGELLLKVRDEVGFGYPWALGDAGDSLANDLILRRLRVERPGDAVLSEEAYDDLSRLQHDRVWIIDPLDGTREFSTPGRDDWAVHIALWQRPSDGQREITDAAVSLPARGNIVYRSDTVTAGAARAGVTDTIRIAVSATRPPAVLHRMRQTLPIQPVAIGSAGAKAMAIIDGDVDAYVHAGGQWEWDSAAPAGVVMAAGMHASRLDGSPMRYNQLDPYLPDFVMCRAELAPILLGAIRDAWR

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Crispr_ID: NZ_CP019221_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019221_4

4287146-4287242

Orphan

Consensus_repeat	Method
TGCCCGGCGTCGGCTGTGGCTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019221_4

>merge|NZ_CP019221|4|4287146-4287242|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGGTGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCCTGCCCGGCGTCGGCTGCGGCTCCGG

>NZ_CP019221|4|4|4287146-4287242|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGG	TGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCC
TGCCCGGCGTCGGCTGCGGCTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019221.1\|WP_042913037.1\|4293803_4294541_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_CP019221.1\|WP_009952956.1\|4293348_4293807_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019221.1\|WP_042912581.1\|4297089_4298097_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239607
NZ_CP019221.1\|WP_080691216.1\|4292073_4292904_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_CP019221.1\|WP_008258618.1\|4278684_4279437_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|234847
NZ_CP019221.1\|WP_008258621.1\|4281584_4282070_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP019221.1\|WP_051445912.1\|4280750_4281485_-\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|274008
NZ_CP019221.1\|WP_042912575.1\|4290498_4292025_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341286
NZ_CP019221.1\|WP_042912568.1\|4282984_4283734_+\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|366780
NZ_CP019221.1\|WP_008258632.1\|4292894_4293356_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP019221.1\|WP_042912578.1\|4296010_4297093_-\|dihydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|226326
NZ_CP019221.1\|WP_042912569.1\|4283750_4284863_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP019221.1\|WP_042912564.1\|4279486_4280698_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NZ_CP019221.1\|WP_042912576.1\|4294645_4296004_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_CP019221.1\|WP_008258652.1\|4298218_4298869_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|132427
NZ_CP019221.1\|WP_042913030.1\|4277652_4278555_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NZ_CP019221.1\|WP_042912571.1\|4284859_4286059_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP019221.1\|WP_036453354.1\|4282141_4282942_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP019221.1\|WP_042913032.1\|4286055_4286838_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NZ_CP019221.1\|WP_042912573.1\|4287265_4290502_-\|carbamoyl-phosphate-synthetase	unknown	unknown	gnl\|CDD\|237263

Protein	Function_ID	Function_description	E-value
NZ_CP019221.1\|WP_042913037.1\|4293803_4294541_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	4.13355e-99
NZ_CP019221.1\|WP_042912578.1\|4296010_4297093_-\|dihydrodipicolinate-reductase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.66987e-38
NZ_CP019221.1\|WP_042912581.1\|4297089_4298097_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239607	cd03531, Rieske_RO_Alpha_KSH, The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway, catalyzing the 9 alpha-hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD). KSH is a two-component class IA monooxygenase, with terminal oxygenase (KshA) and oxygenase reductase (KshB) components. KSH activity has been found in many actino- and proteo- bacterial genera including Rhodococcus, Nocardia, Arthrobacter, Mycobacterium, and Burkholderia.	7.16801e-30
NZ_CP019221.1\|WP_080691216.1\|4292073_4292904_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	6.49165e-22
NZ_CP019221.1\|WP_008258618.1\|4278684_4279437_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|234847	PRK00847, thyX, FAD-dependent thymidylate synthase; Reviewed.	3.54e-100
NZ_CP019221.1\|WP_008258621.1\|4281584_4282070_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	5.01316e-61
NZ_CP019221.1\|WP_051445912.1\|4280750_4281485_-\|cell-division-protein-DivIVA	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	2.28412e-05
NZ_CP019221.1\|WP_042912575.1\|4290498_4292025_-\|AMP-binding-protein	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	1.68965e-133
NZ_CP019221.1\|WP_042912568.1\|4282984_4283734_+\|dienelactone-hydrolase	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	3.47996e-60
NZ_CP019221.1\|WP_008258632.1\|4292894_4293356_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.40179e-12
NZ_CP019221.1\|WP_042912569.1\|4283750_4284863_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.57619e-42
NZ_CP019221.1\|WP_042912564.1\|4279486_4280698_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.37232e-105
NZ_CP019221.1\|WP_042912576.1\|4294645_4296004_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.2479e-79
NZ_CP019221.1\|WP_008258652.1\|4298218_4298869_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	0.000338941
NZ_CP019221.1\|WP_042913030.1\|4277652_4278555_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	7.08269e-146
NZ_CP019221.1\|WP_042912571.1\|4284859_4286059_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.80373e-131
NZ_CP019221.1\|WP_036453354.1\|4282141_4282942_-\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP019221.1\|WP_042913032.1\|4286055_4286838_-\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	1.12702e-124
NZ_CP019221.1\|WP_042912573.1\|4287265_4290502_-\|carbamoyl-phosphate-synthetase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	5.77895e-168

>NZ_CP019221.1|WP_042913032.1|4286055_4286838_-|SDR-family-oxidoreductase
MTSQDLTGRTAIITGASRGIGLSIAQQLAAAGANVVLTARKQEAADEAAAQVGERAVGVGAHAVDEDAARRCVDMTLERFGTLDILVNNAGTNPAYGPLIDQDHARFTKIFDVNLWAPLLWTSLAVKSWMGEHGGSIVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPRVRVNAICPGVVRTRLAEALWKDHEDPLASSIALGRIGEPIDVAAAVAFLVSDAASWITGETMVIDGGLLLGAAQGFRPAPGGGQ
>NZ_CP019221.1|WP_042912571.1|4284859_4286059_-|acyl-CoA-dehydrogenase
MNAVDTAELDARVQALLDEHDPNESDAREFLGAQYDAGLAWVHLPRGFGGLDLPRTAQDRVDARLAAAGAPVGGTPKNYIGMGMAAPTIAAFGTDEQKRKFLRPLFTGEQIYCQLFSEPGGGSDLAGVSTRAVRDPHNPEDWIVNGQKVWTSQAQHAHMAILVARTDPAVPKHAGLTYFLCDMTQPGVEIRPLRQITGEAEFNEVFLTDVRVPDANRLGPEGGGWRVATTTLNNERVAIGSRAGAPREGGHIGKVADAWRAEPALRDPAMHDQLMRLWVEAEVFRLAGERLRQQAATGQPGPEGAGMKVAFAKLAQAISGFEIELHGESGLYYDDWTLRRPETVDLVGRGPGYRYLRARGNSIEGGTSEILRNTISERILGLPGEHRVDKDAAWKDLPR
>NZ_CP019221.1|WP_042912569.1|4283750_4284863_-|acyl-CoA/acyl-ACP-dehydrogenase
MSSLRAATGDLLYSDTEEALRAGVRQLFAERCPPESVAGVYDAQPQDFSGVWRTLATELGVAGLLVPESLGGAGASAREAAVVMEEIGRAVAPVPFLSSAVLATVALLRAGDTRTVSGLAQGELTAALVVPLTTAPGDPVTGVSGGPGGLSGSVTAVAGAGEADVLVVPVTGPDGLELHTVDRAAAGVQVSPLLALDMTRPLAAVTFSGAPSSKVGAGDGPVADAVRTGAALLASEQLGVAQWCFDTTLDYAGQRRQFGRTIGSYQAIKHRLADLWFDVGAAAAAARYAADTCARADDDAAAAAAIAQAYCSDIAVHAAEECIQLHGGIGMTWEYPAHLYLKRAKSDQLAFGTGYRHRARLAELVNLPPT
>NZ_CP019221.1|WP_042912568.1|4282984_4283734_+|dienelactone-hydrolase
MPNITDVVTTPDGTCPVHLFTPDGPESQVPWPGVVMYPDAGGVRGTFEEMAARLAGFGYAVLLPDVYYRTADWAPFDMATVFNDQSERGRLFSMIGSVTPDRMAADATAFFDYLAARPEVSGERFGVCGYCMGGRTSLIVAGRVPDRVAAAASFHGGGLVTDTDDSPHLLADRMSATVYVGGAQNDASFTADHAEQLDKALTAAGVEHTIEWYSAGHGFAVPDNAPYDPAAAERHWDAMTDVFAAAFPR
>NZ_CP019221.1|WP_036453354.1|4282141_4282942_-|thymidylate-synthase
MPIPTPYEDLLRLVLDEGTAKSDRTGTGTRSLFGRQLRYDLSAGFPLLTTKKVHLKSVVYELLWFLRGDSNVGWLREHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPNSRRIIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQSGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLGERDSIFDYTYDDVVVRNYDPHPAIKAPVAV
>NZ_CP019221.1|WP_008258621.1|4281584_4282070_-|dihydrofolate-reductase
MGLVWAQSTSGVIGRGGGIPWNVPEDLARFKEVTIGHTVVMGRRTWDSLPAKVRPLPGRRNVVLSREDGFAADGAQVVGSLDAAFARAEGEPAVWVIGGGQVYLAALPYATRCEVTEIELDLRRDDDDALAPALDDTWVGETGEWQASRSGLRYRFHSYRR
>NZ_CP019221.1|WP_051445912.1|4280750_4281485_-|cell-division-protein-DivIVA
MITEPVKTFSRKFMGYDASAVDAHIEMLTTKQQLLLDDVESLRARLQESGEQTAALRKEVAALTDTSPSSHAMQKRMAKMLQRAVDEVAEMQAEARAEADALIAAAEAEAEAAERKRDEVLADMAAQQKALEAEYEQTKEKLDAELAEMRAETQAAIDEARRNAERECERLLGDAKQGADHYRDKARRAVDEATAQRIEILEQLMGVYRDLDGVPAALEAAYQEQKNPSEDGALAPVDGKVRAS
>NZ_CP019221.1|WP_042912564.1|4279486_4280698_-|winged-helix-turn-helix-domain-containing-protein
MSTRRLSAAQARRIAVAAQGFTEPRPGGQITRVHLKRLISRIQVLQLDSVSVAVRAHYAPVFSRLGPYDRDVLDRAAWGLRSSRLLAEYWAHEAALMAVEDWPLLRWRMRQYRHGRWGTHIVKANPRLAEKVVAAVAELGPSTAGQIEAHLAAGPRGPRGSWWGSRSDTKWVAEALFSAGVLTTATRVGFARHYDLVERVLPAAVLAREVDDDEALRELTLRAATALGVGTEADIRDYFRLSAAQVKPAIAQLLAAGDIERVDVDGWSGPAYLRAGRTVPRVDRGTALLCPFDPLIFFRPRVERLFEFHYRIEIYTPAAKRQYGYYVWPLLMDGRLVARVDLKADRPADTLRVVGTFAEPDAPKARVAAALAGELRSMASWLGLGGFSVSGRGDLAADLRAIS
>NZ_CP019221.1|WP_008258618.1|4278684_4279437_-|FAD-dependent-thymidylate-synthase
MAEIAPLRVQLIAKTEFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHLSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPETDSHVVVPPGMEDDPELRQILAAAADASRATYTELLAKLEAKFADQPNAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAGAAPAVFADFEISALADGTEVATSPLATEA
>NZ_CP019221.1|WP_042913030.1|4277652_4278555_-|4-hydroxy-tetrahydrodipicolinate-synthase
MSTAGFDAPARLGTVLTAMVTPFRPDGSLDTATAAHLANHLIDAGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGSYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQSGLIAHFTTVADATALPVVLYDIPPRSVIPIQPETIRALAAHPNIVGIKDAKADLHSGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLREMLSAFNSGDIATARKINSTVAPLCDAMARLGGVTLSKAGLRLQGIDVGDPRLPQMPATPEQIDALAVDMRAASVLR
>NZ_CP019221.1|WP_042912573.1|4287265_4290502_-|carbamoyl-phosphate-synthetase
MSASLLVANRGEIALRIIRTATELGMRTIAVYADDDAQSPHVHAADEAIVLPGSGPRAYLDQSAMLAVAKRTGADLIHPGYGFLSENAEFADACVAGGVTFVGPDPGVLGLLGNKTAARGAALAAGVPVLPATDGASSVEEVAAFFAAQRGGIMLKALAGGGGRGMRKVHRADQIDDAYQRCAAEAQLGFGDPALYAEALLDDARHIEVQVVAAPAGHQTHALAVGDRDCSIQRRYQKLVEIAPAQGLSDELRRALHQAAVRLCARVGLRGLATVEFLVTGEDFVFLEANPRIQVEHTVTEEITGLDLVAVQLAIAGGTSFYGLGLPAGIASDGLEVIGEPAAQRGIAIQLRVNAETFGPDLSVLPSAGTLTAFTPPSGPGVRVDTYGRPGLAVSPQYDSLLAKVIVHVRGTSWPAALRKADTALSEFGIEGIHTNIGFLRELLRAERVESGWVSTGFVDEKLPELARATQSHQQEPPPASVELYPGEEALRAQLAGTVVEVAPEGVEHAAGSQLVVLEAMKMQHVLVAPDALRTVRTLVTPGQVVGTGDPLLIFTRTESGNDGESARAATDLDRPRADLDEVTRRHALTLDEGRAAAVAKRHQQGRRTARENIADLVDPGSFVEYGALAIAAQRSRRSEEDLIANTPADGLVAGLATIGAQRFGRAAAQAVVVSYDYTVLAGTQGMRNHAKTDRAFDLAARKRLPVVLFAEGGGGRPGDTDVGGAAGLDVPTFRMLAGLRGEVPLVSIVSGRCFAGNAALAGVCDVIIATPDANIGMGGPAMIEGGGLGVYPPEAIGPIGVQRRNGVVGLVARDEAHAVALAKQYLSYFQGSLGEWEEPDPRLARHVVPQNRLRAYDVHRAIEAIVDVGSVLELRPDYGVGIVTALVRVEGVPYGLIANSTHHLGGAIDAEAADKTGDFLALCESFGLPVISLCDTPGFMVGPDAETQAAVRRFGRMFVLGARLTVPLGMIILRKAYGLGAMAMAGGSFRAPQFTIAWPTGEIGGMGLEGAVRLGYSKELAAAEESGDPAERQSLFDRLVAAAYEHGKALRAATTFELDDVIDPSASRAWITRLSGG
>NZ_CP019221.1|WP_042912575.1|4290498_4292025_-|AMP-binding-protein
MIEIARDHNPFPTVGVSRGRDGVPRYDELPATLLDMLAEHVDTRPGSEAVVELGGGRLTYRQLWDRSARVAGGLRAEGIKRGDRVAVRYPAGIDWVLAFWGVVMAGGIAVAVNTRSAQPEVDFVLSDSGAGLDLAPDSPLPDGPPYVSEHLGRADVAALFYTSGTTGHPKGVPTTHEAFLTNTENSLRCSGFARDVGERLRTLISVPLFHVTGCNTQLLVAMRLGGTSVIMPTLNLDELITVLTTERISLMVTVPAVYALLLRHKAFAGTDVSGVRWVGYGGAPIAPSLVRAVQNAFPQATVFNGYGMTETASLATVLPHHDAVEHADSVGYAVPSVDLGVIPFDEDEPGVGELVVRGANVTGGYWNRPEANAATFTDGWLHTGDVVRVDDAGRVHLIDRLKDIINRGGENVSSVEVEAVLLAAPHVADACVLGVPDDVMGEKVGAVLFGGDDDIDVPAVLEHCRGRLADFKVPQYVTVVDTALPRNAGGKLLKARLREQVRWGDPLR
>NZ_CP019221.1|WP_080691216.1|4292073_4292904_+|thioesterase-family-protein
MTNDSAIMPEAFFTVDGDSYVPGAMTQGPWGAAMGGQIVGGLLGWGIEQSGVDADLQPARFTVDLLRPALMSPVQIRTSVLREGRRIKLVDGELVQNGTVVARASALFLRRGDHPDGRVWSFPVEMPPLPTSSDGFPEAMPFLIWGYGATRDGSPGIAAGEWEQSDSQKFAWARIFRPMVQGHPLTPFTRLAFAGDITSSLTHWGTGGLRYINADYTVTASRLPDGEFLGLAAQSHYGTAGVATGAATLFDRHGPLGTSSALALAQPADAFKPTYA
>NZ_CP019221.1|WP_008258632.1|4292894_4293356_-|flavodoxin-family-protein
MSKTLLIVHHTPSPHTHEMFEAVVSGATDPEIEGVEVLRRPALTVSPAEMLAADGYLLGTPANLGYISGALKHAFDCSYYQLLDSTRGRPFGLYLHGNEGTEGAERAVDTITTGLGWSKAAETVVVSGKPGKEQLQACWELGATVAAQLMDYA
>NZ_CP019221.1|WP_009952956.1|4293348_4293807_-|hypothetical-protein
MTKALRTQLLVAFMCVALLVYFALLGRVAVAMIASGRAAAVGLGLAVLVMPVIGLWAMVATLRAGFAHQRLARLIAADGMELDTSDLPRRPSGRIQRDAADALFATVRTEVEDHPDDWRRWYRLARAYDYAGDRRRAREAMKTAVNLQGDHE
>NZ_CP019221.1|WP_042913037.1|4293803_4294541_-|4-hydroxy-tetrahydrodipicolinate-reductase
MRVGVLGAKGKVGSTMVAAVQAAEDLTLSAEVDAGDPLSLLTDGGTEAVIDFTHPDVVMGNLEFLIGNGIHAVVGTTGFTAERLQQVRAWLAESPKTSVLIAPNFAIGAVLSMHFARQAAPFFDSAEVIELHHPHKADAPSGTATRTAKLIAESRKGLPPNPDATSTSLPGARGADVDGIPVHSVRLAGLVAHQEILFGTEGETLSIRHDSLDRTSFVPGVLLAVRRITEHPGLTVGLEPLLNLQ
>NZ_CP019221.1|WP_042912576.1|4294645_4296004_+|HNH-endonuclease
MHSIEVPPEVSAALDALDAAAAAIRGLNFDQLDPAVRLRALERMEASRRRQIAVSHDVIAGLAREDPAALGGPVHKVIADWLRIGCGEASRRLHDATRLSPRLTLTGQELPPELPATAVAWRDGLLDGQHLRVIQSFVRDLPASTPVAKVETAERFLANEAAKLRPDQLQKLAHRYALSINPDGKFSDADRARQRGFTWCGQSPDGMSVGKLVASPELRANLDAWMSHFAAPGMCNPDDETPCVAGEPDDERVRRDLRSHAQRQHDALNALVRGQLGDPKLGQHNGLPVAVIVATTLRELTSGTGRAVTGGGTLLPMRDVIRMGRHAYHYLAVFDEHSSRPLYLGRSRRIASPDQRVVLYAQDRGCTHPGCDAPGYWCEAHHLKEWAAGGATDADNLTFACGPHHRLVEKGWRTRKNARGDTEWIPPPRLDRGVRTNDYHHPERGIGDRAGP
>NZ_CP019221.1|WP_042912578.1|4296010_4297093_-|dihydrodipicolinate-reductase
MSTAPIRVFQVGSGNVGSEMIRRIATQPDLELIGVHAYSPEKVGTDTGEFAGLGTNGVKFTGTIEEIIAAKPDVLTFHGVFPDEDLYLHVLEAGIDIVTTADWITGWHRDTNHPHPSGKPVSKLLAEACEKGGATFYGTGMNPGLNQILGVVCSADVADIENITTIESVDVSCHHSKDTWIEVGYGQPVDDPDIPSKLEKYTRVFADSVYMMADCFDLTLDEVTFSYELGACTKDVDLGWYTLPKGSLGGNYIRYQGMVDGVPRVETHLEWQMTPHTDPSWNIKGCYITQIKGDPCIYNKHMIFPKPGVDLSNPDSFASIGMTVTGMPALAAIKSVIAAPPGLITSADLPLRGFAGRFKK
>NZ_CP019221.1|WP_042912581.1|4297089_4298097_-|Rieske-2Fe-2S-domain-containing-protein
MAKPPLSMKPTGWFQVAWSDEIGVGDVHKIKYFDSEMVAWRAESGQLTVMNAYCEHLGAHLGYGGTVVGEVLQCPFHGWQWSADGRNVCIPYQDRPNRGRRMRTYPVVERNASVYIWHDVERREPYFEPPDVFAAFDDGSSADDYYPQQRLYRETLEMHPQYVLENGVDFAHFKFVHKTPIVPVFTRHDFAEPVSYVDFTITFEGDDGQKIEDVNSGVQAINGGLGIAVTKSWGMIDNRTISAITPVDERTSDVRFMVYIGRAPGGDSERAERKAAEFGQEVIRQFTQDIEIWQHQRYSDPPALAPDEYEGFTAIRQWAKQFYPEAFVSQEGLAQ
>NZ_CP019221.1|WP_008258652.1|4298218_4298869_+|TetR/AcrR-family-transcriptional-regulator
MTRQTSGAGIAGRRPNRRGHATRESMLEAALRSLASGEPGSVSANRIAKDIGATWGAVQYQFGDTDGFWAAVLHRTAERRAATFSTLSAPISPDAPLRERVGAIIDTLYTGLASADSRAIENLRAALPRDPDELERLYPRTAAELFSWGKSWLETCQQAFAGLAVDPDRVREVAALIPGAMRGLVSERQLGSYADLDMARRGLTNALAAYLEPSRP

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Crispr_ID: NZ_CP019221_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019221_5

4880923-4881056

Orphan

Consensus_repeat	Method
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP019221_5

>merge|NZ_CP019221|5|4880923-4881056|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTACCCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGGGGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

>NZ_CP019221|5|5|4880923-4881056|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGG
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019221.1\|WP_042913116.1\|4890223_4891009_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP019221.1\|WP_009955776.1\|4873203_4874226_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP019221.1\|WP_042913108.1\|4874350_4875709_+\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|227607
NZ_CP019221.1\|WP_054585280.1\|4886728_4889854_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP019221.1\|WP_042913117.1\|4892219_4893407_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NZ_CP019221.1\|WP_042913111.1\|4878045_4878297_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP019221.1\|WP_041298262.1\|4869203_4870148_+\|GlxA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227311
NZ_CP019221.1\|WP_008259631.1\|4876692_4878036_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_CP019221.1\|WP_008259667.1\|4891329_4892184_-\|TIGR02569-family-protein	unknown	unknown	gnl\|CDD\|131620
NZ_CP019221.1\|WP_042913114.1\|4881067_4881322_+\|mycoredoxin-Mrx1	unknown	unknown	gnl\|CDD\|131255
NZ_CP019221.1\|WP_014712227.1\|4881333_4882266_-\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699
NZ_CP019221.1\|WP_042913105.1\|4868042_4868396_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380331
NZ_CP019221.1\|WP_014712233.1\|4891011_4891323_+\|DNA-methyltransferase	unknown	unknown	gnl\|CDD\|226219
NZ_CP019221.1\|WP_080691230.1\|4889941_4890178_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019221.1\|WP_042913107.1\|4868415_4869066_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|188314
NZ_CP019221.1\|WP_042913109.1\|4875744_4876611_+\|cyclodehydratase	unknown	unknown	gnl\|CDD\|274832
NZ_CP019221.1\|WP_054585282.1\|4883384_4886732_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP019221.1\|WP_026071234.1\|4870151_4873130_-\|UPF0182-family-protein	unknown	unknown	gnl\|CDD\|234609
NZ_CP019221.1\|WP_042913113.1\|4878701_4880822_-\|ATP-dependent-DNA-helicase-UvrD2	unknown	unknown	gnl\|CDD\|223288
NZ_CP019221.1\|WP_008259653.1\|4882265_4883336_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|367001

Protein	Function_ID	Function_description	E-value
NZ_CP019221.1\|WP_042913116.1\|4890223_4891009_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.28646e-16
NZ_CP019221.1\|WP_009955776.1\|4873203_4874226_-\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	2.9985e-141
NZ_CP019221.1\|WP_042913108.1\|4874350_4875709_+\|zinc-dependent-metalloprotease	gnl\|CDD\|227607	COG5282, COG5282, Uncharacterized conserved protein [Function unknown].	7.68796e-161
NZ_CP019221.1\|WP_054585280.1\|4886728_4889854_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	9.21813e-72
NZ_CP019221.1\|WP_042913117.1\|4892219_4893407_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NZ_CP019221.1\|WP_042913111.1\|4878045_4878297_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	2.08659e-14
NZ_CP019221.1\|WP_041298262.1\|4869203_4870148_+\|GlxA-family-transcriptional-regulator	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	2.41231e-88
NZ_CP019221.1\|WP_008259631.1\|4876692_4878036_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	3.1123e-124
NZ_CP019221.1\|WP_008259667.1\|4891329_4892184_-\|TIGR02569-family-protein	gnl\|CDD\|131620	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein. This protein family is found, so far, only in Actinobacteria, including as least five species of Mycobacterium, three of Corynebacterium, and Nocardia farcinica, always in a single copy per genome. The function is unknown. [Hypothetical proteins, Conserved].	4.73137e-135
NZ_CP019221.1\|WP_042913114.1\|4881067_4881322_+\|mycoredoxin-Mrx1	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	4.87391e-42
NZ_CP019221.1\|WP_014712227.1\|4881333_4882266_-\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	1.62433e-124
NZ_CP019221.1\|WP_042913105.1\|4868042_4868396_-\|hypothetical-protein	gnl\|CDD\|380331	cd20610, Nitro_FMN_reductase_child_20, nitroreductase family protein. Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.	7.56527e-07
NZ_CP019221.1\|WP_014712233.1\|4891011_4891323_+\|DNA-methyltransferase	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.81839e-30
NZ_CP019221.1\|WP_042913107.1\|4868415_4869066_-\|HD-domain-containing-protein	gnl\|CDD\|188314	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family. Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.	2.07454e-16
NZ_CP019221.1\|WP_042913109.1\|4875744_4876611_+\|cyclodehydratase	gnl\|CDD\|274832	TIGR03882, hypothetical_protein, bacteriocin biosynthesis cyclodehydratase domain. This model describes a ThiF-like domain of a fusion protein found in clusters associated with the production of TOMMs (thiazole/oxazole-modified microcins), small bacteriocins with characteristic heterocycle modifications. This domain is presumed to act as a cyclodehydratase, as do members of the SagC family modeled by TIGR03603.	0.000510201
NZ_CP019221.1\|WP_054585282.1\|4883384_4886732_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.82567e-108
NZ_CP019221.1\|WP_026071234.1\|4870151_4873130_-\|UPF0182-family-protein	gnl\|CDD\|234609	PRK00068, PRK00068, hypothetical protein; Validated.	0
NZ_CP019221.1\|WP_042913113.1\|4878701_4880822_-\|ATP-dependent-DNA-helicase-UvrD2	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	5.30193e-121
NZ_CP019221.1\|WP_008259653.1\|4882265_4883336_-\|potassium-channel-family-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	9.10223e-24

>NZ_CP019221.1|WP_042913113.1|4878701_4880822_-|ATP-dependent-DNA-helicase-UvrD2
MDAMPTVADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAAGQVLAVTFTQRAAGEMRSRLRAIDAAAGMGPAVGAVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRARLNASTDEVRDLAGEIEWAKASLIGPEEYPTAVAAAGRDIPLDAAQIAGVYAAYEALKARGEHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDVTPLQQRVLTAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVAGSKLHLVGQRPPGPAPMFHEHPDEPAEAAAVAASIGRLIESGTPPSEIAVLYRVNAQSEIYEEALTEAGIAYQVRGGEGFFNRQEIKQALLALHRASERATARGAEGPLPDVVRAVLEPLGLTAQEPVGTRARERWEALSALAELVDDEVAQRPQLDFPGLLAELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGAESEAVEEERRLLYVGITRARTHLALSWALARSPGGRQGRKPSRFLNGIAPQARAEAGPNKSRRNRATATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLLRLKAWRLDVAKEQKVPAYVVFTDNTLIAIAELRPDDDEALIAIPGIGARKLEQYGPDVLELVRGR
>NZ_CP019221.1|WP_042913111.1|4878045_4878297_-|WhiB-family-transcriptional-regulator
MSAPTAPRPHLPCHAGDPDLWFAEAPADLERAKSLCVDCPVRRQCLAAALERAEPWGVWGGEIFDRGSVLSFKRPRGRPRKAA
>NZ_CP019221.1|WP_008259631.1|4876692_4878036_+|AarF/ABC1/UbiB-kinase-family-protein
MDDGYVADIKRGRAARNAKLASIPVGFAGRAALGFGKRLTGKSRDEVQAELLEKAAHQLFTVLGELKGGAMKVGQALSVLEAAIPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTMQRLVGVFKQLAPGADIQGVVDELIERTEMELDYRLEAENQRAFAKAYHDHPHFAVPRIVASAPKVVIQEWMQGIPMAEIIRHGTTEQRDLVGTRLLELTFDAPRRLEMLHGDAHPGNFMLLDDGRMGVIDFGAVAPLPGGLPIELGMSIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMDLPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAVV
>NZ_CP019221.1|WP_042913109.1|4875744_4876611_+|cyclodehydratase
MTQQCQAALSTYALDPAMPVLLRPDGAVQVGWDPRRAVLVRPPGGLAAAELATLLRTMSSPTPLPELQRRALDRGLTDTEGLRSLVAQLVRAGVATECGRPRGRAPSVRVHGRGPLSELLVESLRCSGARIAHSSQPHAAVSAGDVDLVVLSDYLVADPRMVRDLHDQGVAHLLVRVRDGIGLVGPLVIPGVTSCLGCADLHRRDRDAAWPAICAQLRETVGVADRATVLATAALALSQVNRVIAAVRGQDAASEPEPPQTLNATLEFDLHAGAIVARQWVKHPLCAC
>NZ_CP019221.1|WP_042913108.1|4874350_4875709_+|zinc-dependent-metalloprotease
MADLPFGFSPGEDPDKHGKKDPDSGSNPSDPFAAFGMSGDFGMGDLGQIFTQLGQMFSSAGTVGPGGTASGPVNYELARRVASNSIGFVAPVPDTTNSAIADAVHLAETWLDGATALPAGTAKAVGWTPADWVDNTLETWKRLCDPMAQQISTVWAASLPEEAKSMAGPLLQMMSQMGGMAFGSQLGQALGRLSREVLTSTDIGLPLGPKGIAAIMPDAVESFTTGLERPRSEILTFLAAREAAHHRLFSHVPWLSSQLLGAVEAYAMGMQIDMSGIEELARDFNPASLSDPAAIENLLGQGVFEPKATPAQTQALERLETLLALIEGWVQVVVAAALGDRIPGAGALGETLRRRRASGGPAEQTFATLVGLELRPRKMREAAAFWERLTQAAGVDTRDGIWQHPDLLPNAEDLDEPAGFIDRVIGGDTSGIDEAIAKLEREDPDSDGPVDN
>NZ_CP019221.1|WP_009955776.1|4873203_4874226_-|PDZ-domain-containing-protein
MNRRILTLMVALVPIVVFGVLLAVVTVPFVSLGPGPTFDTLGEVDGKQVVAIQGTLTHPTTGHLNMTTVSQRDDLTLGEALTLWLSDTEQLVPRDIIYPPGKSREEVDKANSADFKQSEDSAEYAALGYLKYPSAVTVAKVPEPGPSAGKLKAGDAIDAVNGTPVATVDAFTGLLKNTKPGQTVTIDYRRKNEPAGVAQITLGSNKDRDYGYLGVAVLDAPWAPFVVDFNLANIGGPSAGLMFSLAVVDKLTTGGLAGSNFIAGTGTITADGKVGQIGGITHKMVAAHAAGATVFLVPAKNCYEASSDNPSGLRLVKVETLSQAVDALHAITSGGQPPSC
>NZ_CP019221.1|WP_026071234.1|4870151_4873130_-|UPF0182-family-protein
MGMRPTARMPKLTRRSRILILIALGVIALLLAGPRLIDAYVDWLWFGELGYRSVFSTVLVTRFVVFLIAGLLVGGIVFAGLAVAYRTRPVFVPSNDNDPVARYRALVLSRLRLVSAGVPVAIGLLAGIIAQSYWVRIQLFLHGGDFGIKDPQFGKDLGFYAFELPFYRLLLSYLFVAVFLAFVANLLAHYIFGGIRLSGRTGALSRSARIQLVTLVGLLVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAGAVFSAVVLRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSIAATRQAYGLTADVVTYRNYTGDAQATAQQVADDRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSIDRYLDRNGSLRDYVVAARELNPDRLIDNQRDWINRHSVYTHGNGFIASPANTVRGIANDPNQNGGYPEFLVNVVGANGNVVSDGPAPLDQPRVYYGPVISNTAADYAIVGRNGADREYDYETSNETKNYTYTGLGGVPLGDWLSRSVFAAKFAERNFLFSNVIGSNSKILFNRDPARRVEAVAPWLTTDSAVYPAIVNKRLVWIIDGYTTLDNYPYSELTSLESATADSNEVAFNRLAPDKRVSYIRNSVKATVDAYDGTVSLYQQDEQDPVLKAWMRVFPGTVKPKSDITPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIAKNDNSSSYQLTSAMNRFKRDYLAAYISASSDPATYGRITVLTIPGQVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVGQGGLLYVEPVYASPGASDAASSYPRLIRVAMMYNDKIGYGPTVRDALTGLFGPGAGAAATGIQPTEAGTPANPPPSAPAPAATPGSPPPAAVPPAPDGSVALSPAKAAVLQEIQAAIGAAKDAQKKGDFAGYGAALQRLDDAITKYNNTK
>NZ_CP019221.1|WP_041298262.1|4869203_4870148_+|GlxA-family-transcriptional-regulator
MVVIVVFDGVTLLDVAGAGEVFVEANRFGADYRLKIASVDGRDVTSSIGTRLGVTDCLSAIDSADIVLVAGSDHLPGRPIDPALVEAVRSVAARTGRMASICTGSFILAQAGLLDGRRATTHWHDARLLARAFRDVTVEPDAIFVRDGDVFTSAGISSGIDLALALVEMDHGTELVRDVARWLVVYLKRAGGQSQFSVLVEADPPPQSPLRAVTEAVAADPGADYSVKKLAALASLSTRQLTRLFQSELGMTPARYVELVRVDFARNALEAGRSVTETAGMAGFGSIETLRRAFVNHLGISPKAYRDRFRTAYA
>NZ_CP019221.1|WP_042913107.1|4868415_4869066_-|HD-domain-containing-protein
MTTSSIDAIAGIHVPDTALAREVTEFIRDTEDELLFNHSRRVYFFGALQGLRRGVQPNLELLYVAAMFHDVGLTEHYRNSTVRFEVDGANAARDFLMDAGADQADADTVWLGIALHTTPGVPEFLAPEVALLQAGVEVDVVGVGREQLAPEALAAVTAAHPRPQFKQRILAAFNDGMKHRPRTTDGTMNADVLAHFDPTFGRVDFVDKILHNSWPE
>NZ_CP019221.1|WP_042913105.1|4868042_4868396_-|hypothetical-protein
MDIYEALYTTRMMRRLRPDPVPLDTQARILDAAVRAPNGANTQRWHELLGVPVEEGWTMSAMLALGYPRGKWGVAANRHPVHEVSSRNGWDKPFGVEVPQPLWPPQDVTASGLAAAS
>NZ_CP019221.1|WP_042913114.1|4881067_4881322_+|mycoredoxin-Mrx1
MTTAPLTVYTTSWCGYCHRLMTVLKSNGIPYEAVDIEHDAAAADFVSSVNGGNRTVPTVKFADGSTLTNPSAAQVKAKLTETGS
>NZ_CP019221.1|WP_014712227.1|4881333_4882266_-|NAD(+)-diphosphatase
MAIADFQLRSVPLLSRVGADRADQLRTDVEAATAGWADAALLRVDSRNQVLVSDGRVVLGAAAELGDKPPSEAVFLGRLEGGRHVWAIRGALQAPEDPDARTEVVNLRSLGPIFDDTSGQLMSSAVALLNWHEKSRFSSVDGSPTRPARAGWSRVNPVTGHEEFPRIDPAVICLVHDGGDRAVLARQAVWPERMFSLLAGFVEAGESFEGCVAREIREEIGLTVRDVRYLGSQPWPFPRSLMVGFHAVGDPAQDFSFNDGEIAEAAWFTRDEVREALAAGDWSSSSESKLLLPGSISIARVIIESWAAID
>NZ_CP019221.1|WP_008259653.1|4882265_4883336_-|potassium-channel-family-protein
MGNGRSRKLSGLDETLTAQRGHQLIGVVRIPEEHASPIRVITRRLAIALVVLFGAAVIVYLDRDGFRDVRNEPLTFLDCLYFSAVSLSTTGYGDITPYTETARLVHTLIFTALRIAFLAVLVGTTLEVLSERSRQGWKIQRWRSRVRNHTIVIGYGTKGKTAVAAILGDETIQAEVVVVDTDRSTLEHAESAGLVTVHGDATKADVLRLAGAQHAASIIVATSRDDTAVLATLTAREIAPNAKIVASIREAENQHLLQQSGADSVVVSSATAGRLLGLATTTPSVVEMIEDLLTPDAGLAIAEREVEQSEVGGSPRHLRDIVLGVVRDGHLWRIDAPEVDAVEANDRLLYIRSVGH
>NZ_CP019221.1|WP_054585282.1|4883384_4886732_-|ATP-dependent-helicase
MNARYNPSELACALGLFPPTEEQSAVIAAPPGPLVVIAGAGAGKTETMAARVVWLIANGYAEPAQVLGLTFTRKAAGQLLRRVRSRLARLAGVGLGPVGDAAAEPEGAPVISTYHAFAGSLLRDYGLLLPVEPDTRLLSETELWQLAFDVVNGYRGELHTDKTPAAVTSMVLRLWGQLAEHLVDTGQLRDTHVELERLVHGLPAGPYQRERGPSQWLLRLLGTQTERAELVPLLDALDERMRAEKVMDFGMQMASAARLAAGFPQVGADLRARYRVVLLDEYQDTGHAQRIALSALFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPRSDGTPAPVLELRTSWRNPPQTLRVANAVSAEARRRSVAVHALRPRPDAPPGTVRCALLPDVVAEREWIADHLDAHYRRARAEGVSPPTAAVLVRRNADAAPIADALRARGIPVEVVGLAGLLSVPEVAEVVAMLRLVADPTAGAAAMRVLTGARWRLGARDIAALWQRARALGGTAADPAPPSPEAIARAADPSHVDADTVCLADAIADPGPAGAYSAAGYQRITALGAELSALRAHLGHPLADLVAEVRRVLGVDCEVRAAAGVAAGWAGTEHLDAFADVVAGYAERADGAATRLDASATASVAGLLGFLDAAETVENGLAPAPLAVARDRVQVLTVHSAKGLEWQVVAVAHLSGGTFPSTASRSTWLTDAAELPPLLRGDRAAAGALGIPVLDTSDVTNRKQLSDKISEHRRQLDQRRVDEERRLLYVAITRAEDTLLVSGHHWGATGVKPRGPSDFLVEIKDVIDRAAVAGDPCGTVEHWAPSPADGERNPLRDNVIEAVWPADPLAVRRDEVERGAALVRRALAAGPGRPCADVDGWAGDVDALLAERARLIEPPVRALPGQLSVSSLVGLARDPAGAAQRLRHRLPSRPDPHALLGNAFHSWVQKFYGAECLFDLGDLPGAADSDVGDSAELAALQTAFTESPWAARTPVAVEAPFEMPIGETLVRGRIDAVFADPDGGATVVDWKTGEPPHGAEALRQAAVQLAVYRMAWAALAGVAESAVRTAFYYVRAGTTVVPDELPSAAELAGLLTDPDGTRCDPRRPSIGEAVPVVT
>NZ_CP019221.1|WP_054585280.1|4886728_4889854_-|ATP-dependent-helicase
MAHTWEADASAVLAPGARGIVRVLGGPGTGKSSLLIDAAVAGIDAGIDPESVLLLTGSGRLGMAERSALTTALLRSRPGRVAVSEPLVRTVHGYAYAVLRRAAERAGDAPPRLVTSAEQDAIIRELLAGDLDDGARATSAWPAQLRPALSTAGFATELRNLLARCAERGIDPGELERLGRHCRRPEWIAAGQFARQYEQVMLLRAAVGTAAPEATTPALGAAELVGAALEAFAVDPELLAAERGRIRVLLVDDAQQLDPQAARLVRVLAAGAELALIAGDPNQAVFGFRGGEPAGLLDGDGPAVTLTTSHRCAPAVARAVSGIAARLPGGGAGRRIDGAGAGEGSVTVRLAASAHAEAAAIADALRRAHLVDGVPWSQMAVIVRSVPRAGARLPRALAAAGVPVAAAAATGPLAEEPAVRALLTVLLAAADGLDGQQALALLTGPIGRVDPVSLRQLRRTLQRANPDRPPGDFAELLVETLSGAVPPGPQFRSLRKVRAVLDAAARCHEAGEDPRYTLWDAWHRSGLQRRWLSVSERGGPAAAQATRDLESVTALFDITDDYVSRTSGASLRGLVEHVAALHLPNANLEPAATAGQVRVLSAHAAMGHEWDFVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTADASMRAPLVAEERRLLVAAMGRARRRLLVTAVDSDTGGADHAAALPSPFFFDIAQWADEDVETTALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDELARDCAATQLARLAKAGVPGADPAGWHGLTPVSTGEPLRGGGDVVTLTPSTLQTLTDCPLRWLAERHGGTNPRDLRSTIGSVVHALIAEPRRSESELLAGLERAWQHLPFAAQWHSDNELARHRAMLEAFVEWRSQSRGALTEVGVEVEIDGTLQTGDGEQVRLRGRVDRLERDAAGRLVIVDVKTGKSPVSKDDAQQHAQLAMYQLAVAEGLVAAGGDTVEPGGARLVYVGKAGAAGAVEREQDPLTADAGDEWRQVIRRAAAATAGPQFVARRNDGCTHCPIRPCCPAHTDGAAR
>NZ_CP019221.1|WP_080691230.1|4889941_4890178_+|hypothetical-protein
MVSRLQKEGLTTMTDEHGFPTDEAPEGDAVEQLRPADSDDDAGLDTDYVSARDREANEADVIEQAYVVSADDERDDDR
>NZ_CP019221.1|WP_042913116.1|4890223_4891009_+|alpha/beta-hydrolase
MTAKLYVHRYGPSGPARILALHGLTGHGQRWQHLSGLLPEIGLAAPDLLGHGRSSWAAPWTIDANVSALAALLDAQAGTPVVVVGHSFGAGLAMHLAAARPNQVSGLLLLDPAIGLDGAWMREIAEAMLSSPDYPDAEEARLEKVHGSWSDVEPALLEAELDEHLVALPNGRYGWRISLPAMMAYWSELARDAVLPPAQTPTILVRAKRTSPPYVTDELIAGLAQRLGSRFRLLDFDCNHMVPYAKPDGVAALARELLGAR
>NZ_CP019221.1|WP_014712233.1|4891011_4891323_+|DNA-methyltransferase
MAPVTDDQVERVRALVAAIPSGRVATYGDIASVAGLSSPRIVGWIMRTDSSDLPWHRVITASGRPARHLTTRQLELLRAEGVLARDGRIALREVRYEFPDGVL
>NZ_CP019221.1|WP_008259667.1|4891329_4892184_-|TIGR02569-family-protein
MTVEPPPDHVLSAFGLAGVKPVYLGASWEGGWRCGEVVLSLVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGTPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWGDVDIFIAADRAAWEERPLASVPPGARVAPATADAERSVELLNQLATLRKPTKSPNQLVHGDLYGTVLFVGTAAPGITDITPYWRPASWAAGVAVIDALSWGEADDGLIERWNALPEWPQMLLRALMFRLAVHALHPRSTAEAFPGLARTAALVRLVL
>NZ_CP019221.1|WP_042913117.1|4892219_4893407_-|adenylyltransferase/sulfurtransferase-MoeZ
MLSVSSLPPLVAPADHLTGDEVARYSRHLIIPGLGVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIVEFDVVEESNLHRQIIHGVADVGRPKAVSARESMLAINPLVDVRLHEVRLDSTNAVELFGCYDLIVDGTDNFATRYLINDAAVLAKKPYVWGSIYQFEGQISVCWEDAPDGRGLNYRDLYPEPPPPGTVPSCAEGGVLGIVCASIASVMSTEVIKLITGIGDSLLGRLMIYDALQMTYRTIAIRRDPSDASRPKITELVDYEQLCGAAADTPVGDATTITPRELRELLDSGKELALIDVREPVEFDIVHIDGAQLVPQSSINSGEGLAKLPRDRMPVLYCKTGVRSAQALAVLKQAGFADAVHLEGGIVAWAQQMQPDMILY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

272945 : 342555

Rhodococcus_phage(20.0%)

transposase,integrase

attL 329332:329391|attR 350920:352439

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042910414.1\|272945_274151_-\|integrase	site-specific integrase	G9FGY1	Rhodococcus_phage	2.9e-113	54.6
WP_042910415.1\|274188_274389_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_142383088.1\|275301_275673_+	hypothetical protein	NA	NA	NA	NA
WP_154074405.1\|276099_276246_-	hypothetical protein	NA	NA	NA	NA
WP_142383089.1\|277257_277998_+	chemotaxis protein	NA	NA	NA	NA
WP_142383090.1\|277994_278717_+	hypothetical protein	NA	NA	NA	NA
WP_051445816.1\|278713_284551_-	relaxase domain-containing protein	NA	NA	NA	NA
WP_051445817.1\|284828_285314_+	hypothetical protein	NA	NA	NA	NA
WP_142383091.1\|285585_285822_+	hypothetical protein	NA	NA	NA	NA
WP_042910451.1\|286481_286664_-	antitoxin VbhA family protein	NA	NA	NA	NA
WP_080691128.1\|286767_287802_-\|integrase	tyrosine-type recombinase/integrase	A0A1P8DJP1	Virus_Rctr41k	2.3e-05	26.6
WP_042910420.1\|287948_288509_-	RES domain-containing protein	NA	NA	NA	NA
WP_042910421.1\|288505_288847_-	DUF2384 domain-containing protein	NA	NA	NA	NA
WP_042910422.1\|292294_292927_-	CAP domain-containing protein	NA	NA	NA	NA
WP_087139799.1\|293288_293747_-	hypothetical protein	NA	NA	NA	NA
WP_051445819.1\|293944_294622_-	hypothetical protein	NA	NA	NA	NA
WP_054585687.1\|294625_296080_-	MCE family protein	NA	NA	NA	NA
WP_042910424.1\|296081_297221_-	MCE family protein	NA	NA	NA	NA
WP_042910425.1\|297217_298549_-	MCE family protein	NA	NA	NA	NA
WP_051445822.1\|298545_299805_-	MCE family protein	NA	NA	NA	NA
WP_042910426.1\|299801_300830_-	MCE family protein	NA	NA	NA	NA
WP_054585688.1\|300887_302231_-	MCE family protein	NA	NA	NA	NA
WP_054585689.1\|302235_303093_-	ABC transporter permease	NA	NA	NA	NA
WP_051445820.1\|303089_303875_-	ABC transporter permease	NA	NA	NA	NA
WP_101930933.1\|305459_306182_-	DNA replication protein	U5N3V8	Enterobacteria_phage	2.4e-46	43.3
WP_042910430.1\|308173_308746_-	protocatechuate 3,4-dioxygenase subunit alpha	NA	NA	NA	NA
WP_042910456.1\|309578_310358_+	IclR family transcriptional regulator	NA	NA	NA	NA
WP_042910432.1\|310956_311868_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_042910433.1\|312131_313052_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_042910434.1\|313112_314246_+	epoxide hydrolase	NA	NA	NA	NA
WP_051445821.1\|314910_316254_+	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_042910435.1\|316250_316793_+	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_042910437.1\|316898_317930_+	2,3-butanediol dehydrogenase	NA	NA	NA	NA
WP_087139621.1\|317984_319238_+	CoA transferase	NA	NA	NA	NA
WP_042910439.1\|319234_320401_+	transporter	NA	NA	NA	NA
WP_042910440.1\|320437_320881_+	DNA-binding protein	NA	NA	NA	NA
WP_042910459.1\|320873_321929_+	hypothetical protein	NA	NA	NA	NA
WP_042910177.1\|322140_323550_+	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_042910179.1\|323570_324107_+	3-phenylpropionate/cinnamic acid dioxygenase subunit beta	NA	NA	NA	NA
WP_042910181.1\|324202_324643_+	cupin domain-containing protein	NA	NA	NA	NA
WP_042910183.1\|324733_325621_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_054585743.1\|325783_326317_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_042910184.1\|326452_327196_+	class II aldolase/adducin family protein	NA	NA	NA	NA
WP_101930916.1\|328340_329375_+\|transposase	IS481 family transposase	NA	NA	NA	NA
329332:329391	attL	NA	NA	NA	NA
WP_080691087.1\|329649_330753_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_080691110.1\|330827_331031_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_080691111.1\|331205_332048_+	2-keto-4-pentenoate hydratase	NA	NA	NA	NA
WP_042910185.1\|333191_334091_+	alpha/beta fold hydrolase	A0A0A7RWQ4	Mycobacterium_phage	4.5e-10	37.2
WP_087139801.1\|334102_335410_+	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_042910186.1\|335412_335928_+	aromatic-ring-hydroxylating dioxygenase subunit beta	NA	NA	NA	NA
WP_042910187.1\|335964_337197_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_054585634.1\|337245_338190_+	extradiol ring-cleavage dioxygenase	NA	NA	NA	NA
WP_042910189.1\|338484_338880_+	DUF732 domain-containing protein	NA	NA	NA	NA
WP_042910040.1\|339409_340474_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_080691086.1\|341883_342555_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	U5P429	Shigella_phage	1.6e-15	33.1
350920:352439	attR	NA	NA	NA	NA

DBSCAN-SWA_2

908625 : 974067

Staphylococcus_phage(37.5%)

transposase,integrase

attL 889021:889040|attR 973863:973882

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
889021:889040	attL	NA	NA	NA	NA
WP_101930856.1\|908625_909258_-\|transposase	transposase	NA	NA	NA	NA
WP_007172184.1\|909434_909905_-	hypothetical protein	NA	NA	NA	NA
WP_007172185.1\|909901_912103_-	hypothetical protein	NA	NA	NA	NA
WP_007172186.1\|912099_913824_-	hypothetical protein	NA	NA	NA	NA
WP_101930855.1\|913823_915314_-\|integrase	integrase	NA	NA	NA	NA
WP_007172195.1\|919072_919399_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_007172196.1\|920247_920868_+	hypothetical protein	NA	NA	NA	NA
WP_040624304.1\|920868_921903_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	7.0e-31	31.5
WP_087139632.1\|922153_923301_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.2e-32	32.4
WP_033717415.1\|924422_925022_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_101930920.1\|925450_926062_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172201.1\|926137_926584_+	hypothetical protein	NA	NA	NA	NA
WP_042910691.1\|926698_927595_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_008263955.1\|927591_930537_-	RND family transporter	NA	NA	NA	NA
WP_007172204.1\|931482_932124_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172205.1\|932372_932537_+	DUF5078 domain-containing protein	NA	NA	NA	NA
WP_008263966.1\|935505_935925_-	hypothetical protein	NA	NA	NA	NA
WP_033721600.1\|936532_937543_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_042909972.1\|939457_940732_-\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	4.8e-98	48.0
WP_042909917.1\|941577_942720_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_042909971.1\|942796_943453_-	transglutaminase family protein	NA	NA	NA	NA
WP_042909918.1\|943449_944907_-	cytochrome P450	NA	NA	NA	NA
WP_007172211.1\|946417_946870_-	hypothetical protein	NA	NA	NA	NA
WP_007172212.1\|946884_947397_-	hypothetical protein	NA	NA	NA	NA
WP_007172213.1\|947393_947729_-	hypothetical protein	NA	NA	NA	NA
WP_033721564.1\|947715_949107_-	DUF1446 domain-containing protein	NA	NA	NA	NA
WP_007172215.1\|949103_949277_-	hypothetical protein	NA	NA	NA	NA
WP_007172216.1\|949733_950888_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_033721567.1\|950928_952116_+	thiolase family protein	NA	NA	NA	NA
WP_033721568.1\|952127_952517_+	Zn-ribbon domain-containing OB-fold protein	NA	NA	NA	NA
WP_157679851.1\|952568_953114_+	hypothetical protein	A0A2P1JQX9	Mycobacterium_phage	6.7e-41	61.8
WP_007172220.1\|953507_955055_-	long-chain fatty acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	9.4e-48	29.6
WP_007172221.1\|955117_956317_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_136244867.1\|956956_957739_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_046184313.1\|957953_958754_-	enoyl-CoA hydratase	NA	NA	NA	NA
WP_007172224.1\|959141_960695_+	long-chain fatty acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.4e-35	25.2
WP_007172225.1\|960787_961846_+	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_033721541.1\|962190_963642_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_085981746.1\|964050_964701_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172228.1\|964757_966056_+	cytochrome P450	NA	NA	NA	NA
WP_007172229.1\|966067_966259_+	ferredoxin	NA	NA	NA	NA
WP_007172230.1\|966380_967439_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_046186391.1\|970328_972116_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	1.8e-82	36.1
WP_007172236.1\|972828_974067_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	1.9e-06	23.6
973863:973882	attR	NA	NA	NA	NA

DBSCAN-SWA_3

979033 : 1043839

Burkholderia_virus(20.0%)

transposase,integrase

attL 978017:978049|attR 1040832:1040864

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
978017:978049	attL	NA	NA	NA	NA
WP_087588774.1\|979033_980291_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.0e-68	53.7
WP_074021014.1\|980967_981459_+	hypothetical protein	NA	NA	NA	NA
WP_007172252.1\|981332_982112_+\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_007172254.1\|982464_982914_-	SRPBCC family protein	NA	NA	NA	NA
WP_007172255.1\|983223_983931_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_080691094.1\|986448_987621_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_042910035.1\|987542_987833_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_087588780.1\|989437_990271_+	hypothetical protein	NA	NA	NA	NA
WP_085981747.1\|990348_991062_+	ABC transporter permease	NA	NA	NA	NA
WP_033721558.1\|991064_991934_+	ABC transporter permease	NA	NA	NA	NA
WP_007172259.1\|991940_993158_+	MCE family protein	NA	NA	NA	NA
WP_007172260.1\|993154_994198_+	MCE family protein	NA	NA	NA	NA
WP_007172261.1\|994194_995760_+	MCE family protein	NA	NA	NA	NA
WP_007172262.1\|995756_997271_+	virulence factor Mce family protein	NA	NA	NA	NA
WP_033721559.1\|997273_998401_+	virulence factor Mce family protein	NA	NA	NA	NA
WP_007172264.1\|998406_999951_+	MCE family protein	NA	NA	NA	NA
WP_007172267.1\|1001620_1002544_-	hypothetical protein	NA	NA	NA	NA
WP_033721575.1\|1004299_1005316_+	diiron oxygenase	NA	NA	NA	NA
WP_007172270.1\|1005528_1006392_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_075362367.1\|1007021_1007828_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_007172273.1\|1007897_1008767_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_007172274.1\|1008738_1010367_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_007172275.1\|1010363_1011317_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_007172276.1\|1011644_1012052_-	hypothetical protein	NA	NA	NA	NA
WP_007172277.1\|1012331_1012619_-	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_007172278.1\|1012645_1013098_-	hypothetical protein	NA	NA	NA	NA
WP_050485493.1\|1013085_1014207_-	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_042909844.1\|1014423_1015227_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	9.3e-31	33.5
WP_042909843.1\|1016188_1016476_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_046182709.1\|1016472_1018938_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909842.1\|1018934_1020158_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_033721569.1\|1021318_1022827_-	carboxylesterase/lipase family protein	A0A0M4JT58	Mollivirus	8.1e-28	32.8
WP_033721570.1\|1022959_1023856_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_007172283.1\|1023908_1024349_-	PaaI family thioesterase	NA	NA	NA	NA
WP_033721572.1\|1024397_1025042_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172286.1\|1025165_1026659_+	acetyl-CoA acetyltransferase	NA	NA	NA	NA
WP_007172287.1\|1026655_1027753_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_007172600.1\|1027795_1029004_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_007172288.1\|1029274_1029820_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_046187034.1\|1033126_1036060_-	MMPL family transporter	NA	NA	NA	NA
WP_042909907.1\|1036056_1036467_-	membrane protein	NA	NA	NA	NA
WP_007172294.1\|1036571_1037765_-	cytochrome P450	NA	NA	NA	NA
WP_007172295.1\|1037830_1038412_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_033717424.1\|1039057_1039681_-	hypothetical protein	NA	NA	NA	NA
WP_087139652.1\|1039665_1040277_-	hypothetical protein	NA	NA	NA	NA
WP_101930934.1\|1040918_1042172_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	6.1e-29	31.1
1040832:1040864	attR	NA	NA	NA	NA
WP_075630243.1\|1042603_1043839_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.7e-84	45.2

DBSCAN-SWA_4

1067780 : 1141105

Staphylococcus_phage(50.0%)

transposase,integrase

attL 1087310:1087326|attR 1132912:1132928

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_008256196.1\|1067780_1068854_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_007168405.1\|1072711_1073584_+	dehydrogenase	NA	NA	NA	NA
WP_007168406.1\|1073736_1074012_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_007168407.1\|1074011_1074404_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_007168413.1\|1079469_1080423_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_007168414.1\|1080419_1081997_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_042909913.1\|1082018_1082564_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_080576328.1\|1082550_1082925_-	hypothetical protein	NA	NA	NA	NA
WP_074021308.1\|1082955_1083777_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_007168420.1\|1084159_1084903_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_042909893.1\|1085000_1085849_+	CoA transferase	NA	NA	NA	NA
WP_019732177.1\|1085845_1087021_+	thiolase family protein	NA	NA	NA	NA
WP_007168424.1\|1087030_1088707_+	long-chain-fatty-acid--CoA ligase	NA	NA	NA	NA
1087310:1087326	attL	NA	NA	NA	NA
WP_007168425.1\|1088703_1089480_+	2,3-dehydroadipyl-CoA hydratase	NA	NA	NA	NA
WP_007168426.1\|1089487_1090636_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_007168427.1\|1090661_1091420_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_046184758.1\|1092407_1093760_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	6.3e-32	34.6
WP_007168431.1\|1094387_1094714_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042909891.1\|1097296_1098532_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.0e-84	45.2
WP_101930903.1\|1099383_1099974_-	hypothetical protein	NA	NA	NA	NA
WP_101930905.1\|1099970_1101065_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_007168437.1\|1102456_1103623_-\|integrase	tyrosine-type recombinase/integrase	A0A2K9VF00	Mycobacterium_phage	1.6e-07	29.1
WP_007168443.1\|1106477_1106909_+	hypothetical protein	NA	NA	NA	NA
WP_101930902.1\|1109561_1111178_+	long-chain fatty acid--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	6.6e-28	25.3
WP_007168450.1\|1111230_1112172_+	R2-like ligand-binding oxidase	NA	NA	NA	NA
WP_007168451.1\|1112378_1112804_+	hypothetical protein	NA	NA	NA	NA
WP_101930904.1\|1112821_1113946_+	thiolase family protein	NA	NA	NA	NA
WP_007168453.1\|1114012_1114906_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_007168454.1\|1114936_1116556_+	acyl--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.1e-30	28.1
WP_007168455.1\|1116788_1117925_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_007168458.1\|1119599_1120817_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_074021181.1\|1121343_1121841_-	ATP-binding protein	NA	NA	NA	NA
WP_007168461.1\|1121948_1123355_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_007168467.1\|1125677_1126004_-	ferredoxin family protein	NA	NA	NA	NA
WP_007168468.1\|1126352_1126631_+\|transposase	transposase	NA	NA	NA	NA
WP_154074411.1\|1126627_1126783_+	hypothetical protein	NA	NA	NA	NA
WP_007168470.1\|1126858_1127308_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_040622630.1\|1128568_1129651_+	dihydrodipicolinate reductase	NA	NA	NA	NA
WP_136244823.1\|1132076_1132358_-	hypothetical protein	NA	NA	NA	NA
WP_157137495.1\|1133274_1133721_-	hypothetical protein	A0A220NQR7	Corynebacterium_phage	2.9e-10	40.8
1132912:1132928	attR	NA	NA	NA	NA
WP_075362207.1\|1134346_1134658_+\|transposase	transposase	NA	NA	NA	NA
WP_101930934.1\|1134673_1135927_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	6.1e-29	31.1
WP_007168486.1\|1138328_1138670_-	hypothetical protein	NA	NA	NA	NA
WP_007168487.1\|1138690_1139098_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_033711258.1\|1139101_1139374_-	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_042909886.1\|1139869_1141105_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	2.2e-84	45.0

DBSCAN-SWA_5

2153870 : 2210438

Tupanvirus(57.14%)

transposase,integrase

attL 2154591:2154650|attR 2216854:2218207

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080691159.1\|2153870_2154536_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
2154591:2154650	attL	NA	NA	NA	NA
WP_087139680.1\|2154644_2155914_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	3.7e-50	41.7
WP_042911237.1\|2155943_2158058_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_080691160.1\|2158063_2159233_+	AAA family ATPase	NA	NA	NA	NA
WP_074021449.1\|2159308_2161849_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_069953761.1\|2165285_2166098_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.8e-32	33.1
WP_042909843.1\|2167062_2167350_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_046182709.1\|2167346_2169812_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909842.1\|2169808_2171032_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_157679854.1\|2172143_2173943_-	hypothetical protein	NA	NA	NA	NA
WP_042911243.1\|2174120_2174381_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042911244.1\|2174801_2175389_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_142383138.1\|2175707_2176139_-	hypothetical protein	NA	NA	NA	NA
WP_142383139.1\|2176169_2176547_-	hypothetical protein	NA	NA	NA	NA
WP_087139682.1\|2176509_2177448_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_042911246.1\|2177846_2180846_-	nocobactin polyketide synthase NbtC	NA	NA	NA	NA
WP_042911247.1\|2180842_2182144_-	polyketide synthase	NA	NA	NA	NA
WP_042911248.1\|2182140_2182875_-	thioesterase	NA	NA	NA	NA
WP_087139839.1\|2182871_2183345_-	acetyltransferase	NA	NA	NA	NA
WP_042911250.1\|2183530_2188519_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	1.5e-94	26.7
WP_087139684.1\|2188500_2192979_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	3.1e-35	23.6
WP_042911252.1\|2193002_2196455_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	4.6e-34	23.6
WP_080691156.1\|2196455_2197844_-	SagB/ThcOx family dehydrogenase	NA	NA	NA	NA
WP_080691157.1\|2199926_2203967_-	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	1.5e-41	24.6
WP_080691115.1\|2204012_2205179_-	PLP-dependent cysteine synthase family protein	A0A1W6JHY1	Lactococcus_phage	2.6e-34	33.0
WP_051445860.1\|2206322_2207066_-	hypothetical protein	NA	NA	NA	NA
WP_072501249.1\|2207979_2208360_-	DUF4189 domain-containing protein	NA	NA	NA	NA
WP_042909842.1\|2209214_2210438_+\|integrase	site-specific integrase	NA	NA	NA	NA
2216854:2218207	attR	NA	NA	NA	NA

DBSCAN-SWA_6

4607366 : 4613942

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042912786.1\|4607366_4609532_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	3.3e-208	51.6
WP_008259183.1\|4609501_4609954_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	5.8e-14	40.2
WP_008259184.1\|4609985_4610225_-	redoxin NrdH	V5UN81	Mycobacterium_phage	1.3e-20	63.2
WP_008259185.1\|4610753_4611308_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.2e-05	34.4
WP_008259186.1\|4611399_4612014_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_008259187.1\|4612022_4613066_+	DNA polymerase IV	F1C5A5	Cronobacter_phage	3.9e-21	29.1
WP_008259188.1\|4613000_4613942_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.2e-05	28.8

DBSCAN-SWA_7

5171691 : 5180337

Burkholderia_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014385777.1\|5171691_5173218_+	cyclic nucleotide-binding domain-containing protein	W8CYF6	Bacillus_phage	1.3e-12	37.4
WP_042913325.1\|5173257_5174097_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_042913327.1\|5174093_5174960_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_008260499.1\|5174987_5175983_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	5.8e-75	46.5
WP_042913511.1\|5175984_5176602_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.3e-27	38.8
WP_042913329.1\|5176801_5177923_+	acyltransferase	A9YX16	Burkholderia_phage	2.9e-14	27.7
WP_042913331.1\|5178052_5179189_+	acyltransferase	A9YX16	Burkholderia_phage	2.6e-18	28.0
WP_042913512.1\|5179248_5180337_+	acyltransferase	A9YX16	Burkholderia_phage	1.3e-16	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019224

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP019221

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection