CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP021473	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-3, complete sequence	0 crisprs	NA	0	0
NZ_CP021471	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-1, complete sequence	0 crisprs	NA	0	5
NZ_CP021477	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-6	0 crisprs	RT	0	0
NZ_CP021472	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-2, complete sequence	0 crisprs	NA	0	0
NZ_CP021476	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-5	0 crisprs	NA	0	0
NZ_CP021474	Pediococcus pentosaceus strain SRCM100892 chromosome, complete genome	3 crisprs	DinG,cas3,DEDDh,csn2,cas1,cas9,csa3	4	2
NZ_CP021475	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-4, complete sequence	1 crisprs	csa3	1	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 981

Planktothrix_phage(100.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_094104115.1\|0_981_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.7e-15	30.6

DBSCAN-SWA_2

5028 : 10116

Lactobacillus_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_094104119.1\|5028_5280_+\|transposase	transposase	Q6J1X3	Lactobacillus_phage	2.7e-37	95.2
WP_151201377.1\|5419_6175_+\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	3.8e-135	97.2
WP_094104121.1\|6457_7111_-	hypothetical protein	NA	NA	NA	NA
WP_094104123.1\|7336_7495_+	hypothetical protein	NA	NA	NA	NA
WP_081035682.1\|7894_8497_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	4.0e-18	39.1
WP_010625593.1\|8972_9293_-	hypothetical protein	NA	NA	NA	NA
WP_151201378.1\|9279_10116_-	AAA family ATPase	F0PIG8	Enterococcus_phage	1.9e-26	33.1

DBSCAN-SWA_3

35045 : 35783

Streptomyces_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_094104130.1\|35045_35783_+	GntR family transcriptional regulator	A0A291LID1	Streptomyces_phage	1.3e-07	39.7

DBSCAN-SWA_4

39564 : 46098

Liberibacter_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_094104133.1\|39564_42726_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	3.7e-22	22.6
WP_094104134.1\|42790_42997_-	hypothetical protein	NA	NA	NA	NA
WP_094104135.1\|43241_43979_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_094104136.1\|44104_44491_-	hypothetical protein	NA	NA	NA	NA
WP_094104137.1\|44483_44804_-	acetyl-CoA carboxylase	NA	NA	NA	NA
WP_094104138.1\|44796_46098_-	Y-family DNA polymerase	M1Q231	Streptococcus_phage	2.3e-79	38.9

DBSCAN-SWA_5

51164 : 52283

uncultured_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_094104142.1\|51164_52283_-	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	A0A218MNE0	uncultured_virus	1.3e-75	42.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP021474

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021474_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021474_1

78043-78155

Orphan

Consensus_repeat	Method
GGCGTTCAACAATTAGATTCAGGAAGTCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP021474_1

>merge|NZ_CP021474|1|78043-78155|CRISPRCasFinder
GGCGTTCAACAATTAGATTCAGGAAGTCACACATTGAATAGCGGACTTCAAACTCTAAATGGAAGCACAGGAACCTTGATTAGCGGCGTTCAACAGTTAGATTCAGGAAGTCA

>NZ_CP021474|1|1|78043-78155|CRISPRCasFinder
GGCGTTCAACAATTAGATTCAGGAAGTCA	CACATTGAATAGCGGACTTCAAACTCTAAATGGAAGCACAGGAACCTTGATTAGC
GGCGTTCAACAGTTAGATTCAGGAAGTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021474.1\|WP_094104228.1\|89072_90479_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235798
NZ_CP021474.1\|WP_094104226.1\|84664_85651_+\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NZ_CP021474.1\|WP_049752783.1\|74672_75176_+\|DUF1836-domain-containing-protein	unknown	unknown	gnl\|CDD\|378076
NZ_CP021474.1\|WP_094104214.1\|66301_67480_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP021474.1\|WP_002834184.1\|86783_87764_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP021474.1\|WP_061812202.1\|72747_73587_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236841
NZ_CP021474.1\|WP_094104227.1\|85662_86781_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP021474.1\|WP_094104217.1\|70523_72329_+\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NZ_CP021474.1\|WP_094104215.1\|68278_69115_-\|manganese-catalase	unknown	unknown	gnl\|CDD\|252986
NZ_CP021474.1\|WP_094104212.1\|60903_61902_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378229
NZ_CP021474.1\|WP_094104213.1\|62889_64140_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP021474.1\|WP_094104216.1\|69268_70381_+\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NZ_CP021474.1\|WP_094104225.1\|83042_84386_+\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP021474.1\|WP_088355895.1\|87756_89070_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP021474.1\|WP_094104221.1\|79190_79826_+\|DUF4767-domain-containing-protein	unknown	unknown	gnl\|CDD\|374270
NZ_CP021474.1\|WP_094104223.1\|80773_81487_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP021474.1\|WP_094104218.1\|73789_74653_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NZ_CP021474.1\|WP_094104224.1\|81645_83028_+\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP021474.1\|WP_094104222.1\|80066_80738_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380313
NZ_CP021474.1\|WP_094104219.1\|75267_75588_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042

Protein	Function_ID	Function_description	E-value
NZ_CP021474.1\|WP_094104228.1\|89072_90479_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_CP021474.1\|WP_094104226.1\|84664_85651_+\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	1.04487e-87
NZ_CP021474.1\|WP_049752783.1\|74672_75176_+\|DUF1836-domain-containing-protein	gnl\|CDD\|378076	pfam08876, DUF1836, Domain of unknown function (DUF1836). This family of proteins are functionally uncharacterized.	9.77839e-38
NZ_CP021474.1\|WP_094104214.1\|66301_67480_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	8.14473e-50
NZ_CP021474.1\|WP_002834184.1\|86783_87764_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.88289e-177
NZ_CP021474.1\|WP_061812202.1\|72747_73587_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	9.49957e-41
NZ_CP021474.1\|WP_094104227.1\|85662_86781_+\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	4.21769e-159
NZ_CP021474.1\|WP_094104217.1\|70523_72329_+\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	1.17059e-114
NZ_CP021474.1\|WP_094104215.1\|68278_69115_-\|manganese-catalase	gnl\|CDD\|252986	pfam05067, Mn_catalase, Manganese containing catalase. Catalases are important antioxidant metalloenzymes that catalyze disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese.	1.34329e-119
NZ_CP021474.1\|WP_094104212.1\|60903_61902_+\|hypothetical-protein	gnl\|CDD\|378229	pfam09648, YycI, YycH protein. This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.	6.39552e-69
NZ_CP021474.1\|WP_094104213.1\|62889_64140_+\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.2076e-82
NZ_CP021474.1\|WP_094104216.1\|69268_70381_+\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	6.60421e-45
NZ_CP021474.1\|WP_094104225.1\|83042_84386_+\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	1.12903e-116
NZ_CP021474.1\|WP_088355895.1\|87756_89070_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	8.26939e-160
NZ_CP021474.1\|WP_094104221.1\|79190_79826_+\|DUF4767-domain-containing-protein	gnl\|CDD\|374270	pfam15983, DUF4767, Domain of unknown function (DUF4767). This domain family is found in bacteria, and is approximately 140 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	2.05173e-47
NZ_CP021474.1\|WP_094104223.1\|80773_81487_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.35362e-55
NZ_CP021474.1\|WP_094104218.1\|73789_74653_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	4.80716e-93
NZ_CP021474.1\|WP_094104224.1\|81645_83028_+\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	8.66459e-172
NZ_CP021474.1\|WP_094104222.1\|80066_80738_+\|hypothetical-protein	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	3.68688e-30
NZ_CP021474.1\|WP_094104219.1\|75267_75588_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.1075e-14

>NZ_CP021474.1|WP_094104219.1|75267_75588_+|winged-helix-turn-helix-transcriptional-regulator
MVKNNAALAAFKKNIPLLDALSDERRQQIMITLGESDAGLTVSELTKLIGLSQPAVSHHIKQLKDLNLVSVRKVGTSNIYQLTIKDALARVQELIDILRKDKKLLR
>NZ_CP021474.1|WP_049752783.1|74672_75176_+|DUF1836-domain-containing-protein
MDSKQLENFAKMSLPKWDELPNIELHLDQVIDLANNYLRPLEVDLLTPTMMHNYLKQAVIIRPQGKLYGRMQLAAVIIIGCLKSILSLDEIKRGFEAELKLTSSRRAYNNFVNAFNEEVQRISQHGPRNLWNELLAETAVVSLQHSAIISMLTKKMAKDLLSDLEEK
>NZ_CP021474.1|WP_094104218.1|73789_74653_+|DegV-family-protein
MLKQKIAVLVDSCSDVPAEIANREYFEMIPMGVFFVEEEYQDRVNIEPDEFYQKLAKANPLPTTASPKGELITKALDNLSKRGFTQIIAVCISSGLSGTAQQVKIYAKNYPQLQIEVIDTKNIGIASGFAAVRASEVIEEGWEFDQIVEEVQRVANQTKVFFYVPTLKYLIAGGRIGRVAGLVGSIINLKPIISCDDEGIYYPVAKAHGEKKALKKMLQLVDDTLKNAQKFNLAVVHGLNEGLMNQISTEFKNKYPNMGKFYNGDISPALGVHTGPGLIGIGVQIIK
>NZ_CP021474.1|WP_061812202.1|72747_73587_-|methyltransferase-domain-containing-protein
MNKIELATQFIQRHLHQFQCPICKSNFNEVQSGTLICNNQHSFNIAKKGSLFFLNNPVNTEYTNEMLTYRNQFLTAGFFNPMLEEVINNISGDLILDAGCGEGTTTKWMASHFDGDFVGLDISKPAINIAGSGIAPQPYPLFMVGDLAQLPFADQGLTSIVNILSPANYQEFDRTLATHGELIKVIPGNHYLSELRQLVYPDGEHATYDNAPVKNHFIEHYEYVEFSKISYKFPLDDKLFTALFNMTPLTWQAQDRKEAILQDGLKEITAEFEIGVVRK
>NZ_CP021474.1|WP_094104217.1|70523_72329_+|DUF2207-domain-containing-protein
MKFFTKRTFLLLVTMLTFGIFWNVKTVKADYEISQFRMQINVNKDGSANINQSVLYDFDDDYHGVYLTQDLRGTAGAELEGITVSNNKGTQNQVPINNSGENLTAKVESSKKQMKIKVYNAVSSDDQTKITYHYRINGVVTNYKDTAEINWKVIGSGWDVPLEDAQVTIKLPGKNVKGLHAWSHGEAAGYTTVDKAKGKVTLDIGDNPENTFVEAHMVFPTALTPDNKKIVNQNHLAAVKKQEYQLVKRENEAQARARRIAAYAKITSAIISVLILIGMMGWLKKHGYHRYDIPTPMEHSFDVPSISPAEAEALFNKSKADTKGVSAEMLVLAAEGKLKFKQILYGKRGKETTEIERQGKFNMSFVDRCLDRIGDGQQVTIKQINDYAKKDKKNNVATWYKEWQSEVDANLARFKDTYNISYRHGLLGLAITTPILAFIVGIIGRFGEVTNLYWIGGIVLTLIIEAWVLATWDKVSMYNEAGLQQYNQIRGFKQMMKDIAHFNTAEIGDLILWEQILPYATAFGLAEKVAKKLKTDFGTQLNENVPFYAYYYGINGMHVGIANSISTSISHSVSASSSGSSGGFSGGSSGGFGGGSGGGAF
>NZ_CP021474.1|WP_094104216.1|69268_70381_+|low-temperature-requirement-protein-A
MKNELLKKVSMIELFYDLVFVYMISQVTGLIHHLQNGVISPSALSIFTLVVIVSINSWMVQTVFNNRYGKSQWSNVILSFVDMAIVLYMSNAFSDTFDRHLIGFFIAAGLLSLTLAIQYLLVFVQTKNEYDRNIAMAFMRILFFRTACLLAGGVLAGRWGTTIALFGIITSWIIPAFTGKHTQKHPIIFSHLLERLTALIIIMFGETIVGISKYFTQNTFSIQSIMIFIIVVSLFFTYIVEFDHLIEEQRTHETGNLLIYLHYFILFGLSLVTVALDFIHESEANAIFSITCLYVGIALFYIGIVIASYYNKTTLKLENYVVIAFTVVTLMGYFTSMCFATFSIIAGVTALTTLINAVVITLSLVRRYER
>NZ_CP021474.1|WP_094104215.1|68278_69115_-|manganese-catalase
MFKHQKELQFEAKPDRPDPIVAKYLQELIGGQYGEMSVAMQYLFQGWSCRGEEKYKDMIMDIATEEIGHVEMLATMVARLLEDAPIADQQAAMQANPTVGAIISGMNPQHAIVAGLGPRPADSVGNPWSGAYIIASGNLLADFRANLNAESQGRLQVARIYEMIDDQGVKDLLSVLLARDSYHQNLWASAVKELEEKEDSMLVPTTFPRDKERKDIAYDFYNFSQGDESSTGPWASGEALDGEGEYHWYDEPKVEGSAPNLKPVSPKMYGTPENKSEI
>NZ_CP021474.1|WP_094104214.1|66301_67480_+|GGDEF-domain-containing-protein
MENTVMNTIIYWAKGFFSFNTVVIAAITVGVLFMLAAGTYVVEMNMDKTKTSSTLIEELLWGVGLTIAMVFLQNVFTHLYSTIASSELGWEYSTAQFVVLFYCLYIVHRKVVLWFNIILPMYVYGLGIVRGQIGFDIAPILAILVIILISYTIYQQNDTLIDENVKYYSTLIMFGLAWWFVLKDIHHLTIVDIMCLTLEFLIAMSIVHFGNKKVRMIMKQYLNLMQEVDTDALTGVYNRNSFNKIVEGVFEFYSNNDAPLTMVMFDIDHFKQFNDQYGHQVGDKVLRLVADRFSYELVDRKAHGQLFRVGGEEFAIIFRGRTADDCEKIVRAIRDDLVKETIRVNNHDRVGIKVSIGISQLRDDDFDFQTFYKRVDDYLYQSKRNKRNSITV
>NZ_CP021474.1|WP_094104213.1|62889_64140_+|PDZ-domain-containing-protein
MKTNKLIIVAAIAGLLGGGVAYGGASFIHNQMESSSTAVPTGSNTTGTTKTSNVKVNVSSQSSKAFSTIKDSVVSVINLQRANTNDSDSIISSIFGNESSSSSKSSSSSSELETASEGSGVIYKKSGDTAYIVTNNHVVSGSSSLEIIMSNGKKLPAKIVGTDSVTDLAVLKINSSAVTTVASFGNSDNIKVGETALAIGSPLGSEYATSLTQGIISAKKRTVETTTENGQNNGEATVIQTDAAINAGNSGGPLINLAGQVIGINSMKLSASGSDSTTVEGMGFAIPSNEVVTIIDQLVKNGKITRPALGVALVDLTQVSSTQQKSILKLPSNVTDGTVLMQVNNGPAKTAGLKKYDVITKIDDKAITDTAGLREALYKHKINDKITVGYYRDGKYKTTVVTLTKTSTTTSSTTTK
>NZ_CP021474.1|WP_094104212.1|60903_61902_+|hypothetical-protein
MDFRKIEVIFIVVFAILNAYLFGSYWQYQLEAGTTSSSNSSENSTILKEMRNDQITYMPLSNKKMNGYYASATVDTSLKDNIKRLTDQSARVVDNYVESTLNEELTVDPKQPQKVLNTFVKNRYNIVYGSEYQYNPNLSTSVQVVYTQMIDGHPVYSKAGKLTFYVNASNEVTGYTQGHLVNEKQLREKSELISQTRAVTWLYQYNEIQNDSKVEWADLGYTNLLTTDNGVVYVPTWVIGIKSKSSTGIQVKRINAFSGVLIKKDHEVTTESSTQASGSTAASDDSSSVSSTETSESEATSASSDVSSTTSSTSSATTEAGVEATTSTSTTY
>NZ_CP021474.1|WP_094104221.1|79190_79826_+|DUF4767-domain-containing-protein
MRHMKKPEKRSFGSINSVVWVILALIVVIAGYKFFYPNHVTNTTSSSNRSSSTKVIKVEEGKSSSSKAQSSSKKTKKTEKKIWTDKQDSELAAFISSWQQTMGQTYTGTNANASVSFGGVSFPDYLSKGQIYVNQQEVSMQWTRSEKADSEYKVVAVYTGDQYMYLFTFHNGQPEVLVTSQSASDGMNFKVTENADLVAEFQKVAAENTDK
>NZ_CP021474.1|WP_094104222.1|80066_80738_+|hypothetical-protein
MRRFRQDGSQTGNSKASFRTSFYGSKIDSKQLKEMIGIAQKAPSWVNSQPQKVYVAQGETLEAIRKQQQELAITGAKTNSDIPPMSRKLWSEQAQKNMAEWSHGIPAVLGDNWQETLGKEASQLYNAQAVVYLTLPKGYIPWSLFDLGAFSQNILLATTEQGIDSIVAYNFVKYPQILREELKIPDDEEIIVGIGLGFEDEQAQVNRITSKRMDTESILKIKK
>NZ_CP021474.1|WP_094104223.1|80773_81487_-|GntR-family-transcriptional-regulator
MYKYEKISQAIRKQIIEQKIKPGALLPDQNQLAKEFNTTRITIGKALQSLIIEGLIYSKRGAGTFVRKDAHLNDEFTNDVDKPLGTTSTHPHSKVTSKYIHLTARIANDVEKKNLLLEDGETVYVIKRTRFIEGKAYSYEQTIMPTKIATITEEVLKKSIYQYLEHEYHLELAGSHRQITARKVSEEDAKFLGEKLGDPILVISQTSYLVDGTPFEFSESRFPYQSSAVSADVNLLE
>NZ_CP021474.1|WP_094104224.1|81645_83028_+|glycoside-hydrolase-family-1-protein
MKGKLPDNFLWGNSTSSMQTEGGVHEGGKGPSVYDTYEATETTSNWDVAIDNYHHYEEDLDLMANQGMNCYRFQISWSRINPTGDGDFNEEGIQYYDRLINGLLKRGIKPMICLYHFDMPLHLAEKYNGFMSRHVVDAFVRFGKKMVDCFSDRVKLWVTFNEQNLYSQTEAFHIAGYLKGDQTDEELQLIAHHVMTAHAQVANYVHETSDAQIGGMLAYVESYPKNCRPRDVYVARQIDEFLNRNLLEVWVHGHYSTEVTQYIKNHHFDIDFTEQDQIAFEKLKSDFISFSYYASNVVDSTKIPQGTMPNRYLDYGGAENPYLKATDWGWNIDPLGFRDVITKTYNEYGIPMFPIENGIGYREIFDGTEIQDDYRIEYHRDHIQAMIDAVVEDGVPVLGYLGWGLIDIPSSSGNMEKRYGMVYVNRGNHELRDMKRVPKKSYKWFKKVIETNGNDLENNL
>NZ_CP021474.1|WP_094104225.1|83042_84386_+|PTS-sugar-transporter-subunit-IIC
MGSSNKESVNDKMQNSKFIAKFTEISVKVGNWVYLRSLRDAFAVILPMFIVAGIGVLLNNVVFTWFLSGDMLTKFQVIGNAIVNGTLNVAGILVAPMIGYSLARNKGFNNPIAAAAMSLASIFILMPGSIQLGTVASAGAKMATVTGGLSYLNTGTQGMFGGIFVGLIATGLFIKLASIKELQIHLGENVPPAVAASFSVLIPAILLMSFFAIIAALLAGFFNTDLINLIKTWIQEPLRGFNTSIVGYCVIYTLANFLFGLGIHQTVLSGALLDPLVLVNMNENMTAYAHHQAIPNIITTSFVSNYTLIGGSGSTIALIIAILIFSKAKSSRQIAGLSLAPGIFNINEPMIFGFPIVFNLPLIIPFVLFPVVGSLMGYFATLWGWVSRTVVLVPWTTPPLIGPYLSTAGDWRAVILQILIIVVGVFLYLPFLKISERVSEIQAEENL
>NZ_CP021474.1|WP_094104226.1|84664_85651_+|lipoate--protein-ligase
MRYVTYMGTDAYTNIATDTWLLNNLNAKEPVFALWQNNNAIIVGQNQNTFGEVNKDFVDEHQIEVVRRVTGGGAVYHDLGNLNFTLFVPIESAANVDFKKFSEPVLRALHTLGIDAEASGRNDLLVNGKKISGVAQRYAKGYLMHHGTLLFDSNVDTMVRSLNVADEKFISKAAKSVRSRVGMIKDAAPKGLTLQDFWDAVQYELTDHGKDQEIVLTPQQKQEIIQLTADKFSTWDWNYGRSPEFNFKNHAKYDGGIIDVQVQAEGGTIRDINFTGDFLGLRDWREIKDQFIGLPFETAEIKTVFERNHEGRYFGNITDDELIKLFEA
>NZ_CP021474.1|WP_094104227.1|85662_86781_+|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MAVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLNEDQLVELMKQMVFSRVLHERSTKLAKQGRLGFYAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAALGLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDGMDPIAMYLASKKARQWAVDGNGPVFIETVTNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGLWSEEIENDWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK
>NZ_CP021474.1|WP_002834184.1|86783_87764_+|alpha-ketoacid-dehydrogenase-subunit-beta
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIMEIQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSAVESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVSPLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVKEVVNFD
>NZ_CP021474.1|WP_088355895.1|87756_89070_+|2-oxo-acid-dehydrogenase-subunit-E2
MTEIFKMPDIGEGMAEGEIANWLVKVGDTIKEEDAVAEVQNDKLLQEILSPYGGKITKLFVEAGTVVKVGEPLIEFDGDGSGAGAESEAPKETPASTEPEPESSAPANQTAPEVTKVGAEYTSNGQLLAMPSVREYARKNDIDLTQVPATGRHGHITMADVENFKASPASAPTASPAPAASVPETESEKAPSAPATPAAPAEVKAGRVPLSPVRKVIAKTLTNQVQTIPHVTIMDEVEVSKLMDLRNQFKEQAKQKGYKLTYMPFIAKALAGAAHKYPELSAMVDIEKQEIVYYEDTNVSFAVDTDNGLFVPNVKNVKSKSIMEVAQEIDDMAIRGRAGDLKPNELKGGTVTITNIGSESGSGFFTPIINPGESAILGIGRIRKTPVVNEDGELAVGNTLKLSLSFDHRLIDGALAQKIMNELKALLSNPAYMLMEV
>NZ_CP021474.1|WP_094104228.1|89072_90479_+|dihydrolipoyl-dehydrogenase
MVVGTQAINVDTLIIGSGPGGYVAAIRAAELGQKVVIVERDYIGGVCLNVGCIPSKALIQAGHLYSTLQHGNPFGVSVSESKIDFTKTQEWKQNQVVNKLTGGVELLLKKHKVEIVRGEAYFNDNETVNVINGDDSHVYRFKRALIATGSRPVEIPHFKFSGRVIDSTGALNLKDVPEHLIIIGGGVIGAELAGAYMNLGSKITIIEGLDHILNGFDGELIQPVLNNFKKNGVEIVTEAIAVEANQTDKDVTVTYEADGTTKTVTGDYCLVSVGRRPNTDQLGLNNTNIKLSKRGLIEVNDSMQTSVKHIYAIGDVVAGPALAHKASFEAKVAAAAMGGEDAHDTHYVLPAVAYTNIELATVGETPQSIAEKKLDAKSSKFPFAASGRAMTMDQTEGFIRLITDNPTGGIIGAQIVGPEASNLISELTLAIENGLTIKDIELTIHPHPTLGEEIMDAAELAAGLPIHV

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Crispr_ID: NZ_CP021474_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021474_2

1153887-1153992

Orphan

Consensus_repeat	Method
CAGATGCTCTACCAACTGAGCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021474_2

>merge|NZ_CP021474|2|1153887-1153992|CRISPRCasFinder
CAGATGCTCTACCAACTGAGCTAACGGCTCAAAATATAATGGGGGATACAGGGCTCGAACCTGTGACCTCCTGCTTGTAAGGCAGATGCTCTCCCAACTGAGCTAA

>NZ_CP021474|2|2|1153887-1153992|CRISPRCasFinder
CAGATGCTCTACCAACTGAGCTAA	CGGCTCAAAATATAATGGGGGATACAGGGCTCGAACCTGTGACCTCCTGCTTGTAAGG
CAGATGCTCTCCCAACTGAGCTAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021474.1\|WP_094104611.1\|1136637_1137459_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NZ_CP021474.1\|WP_094104614.1\|1145264_1145897_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP021474.1\|WP_002833751.1\|1137703_1138363_+\|deoxynucleoside-kinase	unknown	unknown	gnl\|CDD\|224345
NZ_CP021474.1\|WP_060743922.1\|1150200_1151934_-\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|213733
NZ_CP021474.1\|WP_002833906.1\|1168970_1169816_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP021474.1\|WP_094104613.1\|1139886_1140606_-\|16S-rRNA-pseudouridine(516)-synthase	unknown	unknown	gnl\|CDD\|211327
NZ_CP021474.1\|WP_029257840.1\|1166334_1168554_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_CP021474.1\|WP_002833905.1\|1168608_1168971_-\|DUF1634-domain-containing-protein	unknown	unknown	gnl\|CDD\|377927
NZ_CP021474.1\|WP_002833902.1\|1165529_1165796_-\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NZ_CP021474.1\|WP_002833746.1\|1142502_1144920_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP021474.1\|WP_061812656.1\|1162959_1163733_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP021474.1\|WP_094104615.1\|1145889_1146453_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377744
NZ_CP021474.1\|WP_002833898.1\|1160628_1161645_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP021474.1\|WP_094104612.1\|1138440_1138845_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|223662
NZ_CP021474.1\|WP_029257843.1\|1161694_1162870_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340844
NZ_CP021474.1\|WP_011673188.1\|1136432_1136633_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021474.1\|WP_002833897.1\|1159580_1160615_-\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NZ_CP021474.1\|WP_002833742.1\|1148038_1149229_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP021474.1\|WP_094104616.1\|1163805_1165530_-\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP021474.1\|WP_094104617.1\|1165941_1166130_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021474.1\|WP_094104611.1\|1136637_1137459_-\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.85693e-63
NZ_CP021474.1\|WP_094104614.1\|1145264_1145897_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.03702e-52
NZ_CP021474.1\|WP_002833751.1\|1137703_1138363_+\|deoxynucleoside-kinase	gnl\|CDD\|224345	COG1428, COG1428, Deoxynucleoside kinases [Nucleotide transport and metabolism].	1.22015e-70
NZ_CP021474.1\|WP_060743922.1\|1150200_1151934_-\|pyruvate-oxidase	gnl\|CDD\|213733	TIGR02720, Pyruvate_oxidase, pyruvate oxidase. Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic].	0
NZ_CP021474.1\|WP_002833906.1\|1168970_1169816_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.61547e-34
NZ_CP021474.1\|WP_094104613.1\|1139886_1140606_-\|16S-rRNA-pseudouridine(516)-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	3.71213e-88
NZ_CP021474.1\|WP_029257840.1\|1166334_1168554_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP021474.1\|WP_002833905.1\|1168608_1168971_-\|DUF1634-domain-containing-protein	gnl\|CDD\|377927	pfam07843, DUF1634, Protein of unknown function (DUF1634). This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many hydrophobic residues.	1.23608e-28
NZ_CP021474.1\|WP_002833902.1\|1165529_1165796_-\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	1.69391e-54
NZ_CP021474.1\|WP_002833746.1\|1142502_1144920_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP021474.1\|WP_061812656.1\|1162959_1163733_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.50502e-24
NZ_CP021474.1\|WP_094104615.1\|1145889_1146453_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	1.4556e-73
NZ_CP021474.1\|WP_002833898.1\|1160628_1161645_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	5.79241e-34
NZ_CP021474.1\|WP_094104612.1\|1138440_1138845_-\|universal-stress-protein	gnl\|CDD\|223662	COG0589, UspA, Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms].	2.65909e-20
NZ_CP021474.1\|WP_029257843.1\|1161694_1162870_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	3.30675e-136
NZ_CP021474.1\|WP_002833897.1\|1159580_1160615_-\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	8.50457e-33
NZ_CP021474.1\|WP_002833742.1\|1148038_1149229_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP021474.1\|WP_094104616.1\|1163805_1165530_-\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0

>NZ_CP021474.1|WP_060743922.1|1150200_1151934_-|pyruvate-oxidase
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPGAVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVTIPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALAKGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILADSHKFLKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQAQRFTTSGWYATMGYALPAAIGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQPHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDVKITNLRPLPVEQLLLDKETQDPEAVEQFVKKYHAESLIPFRKLLEEA
>NZ_CP021474.1|WP_002833742.1|1148038_1149229_-|methionine-adenosyltransferase
MSERHLFTSESVSEGHPDKIADQISDSILDELLKNDPDARVACETTVTTGLVVVVGEISTTAYIDIQKVVRKTIKDIGYVGGEYGFDGENCAVIVAIDEQSPDIAQGVDDSLETREGHEDRLNQIGAGDQGLMFGYATNETEELMPLPIMLSHHLMQRIAKLRKEQVISYLRPDAKAEVTVEYDDNDHPVRVDTVVLSTQHDPDVTLEQIRQDVIEQVIKAVIPATLLDENTNFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGAARHGGGAFSGKDATKVDRSASYAARYIAKNIVAAKLAERVEVQIAYAIGVAEPVSVMVDTFGTGTVSEEKLTQAVRKIFDLRPAGIIEMLDLKRPIYKQTAAYGHFGRTDVELPWEKTDKVEALNDFFKN
>NZ_CP021474.1|WP_094104615.1|1145889_1146453_+|methyltransferase-domain-containing-protein
MLDNAMQYSHQLLTEIVQPGDVVIDATMGNGHDTLFLSELVQSTGRVFSFDVQKAALEQTRALFEHQHQTLINVELIHASHDQIDHYVTEPITGAIFNLGYLPGGDKSIITHPTSTISAVQQSLNQLKIGGRIILVCYYGHPGGQEELQQLLSFVAELNQHHYSCLRYEFINQINNPPILLCIERKK
>NZ_CP021474.1|WP_094104614.1|1145264_1145897_+|phosphatase-PAP2-family-protein
MHSRKYTHLLINILPTPLFILIVSLVIFKPSWVHAYDNSISSLVQSVQTPGFNQVVSIYTQLGNSIPYIIISLIVCLILILKHLKKAALFLACNIVLGNGLNHLIKQIIQRQRPEFRLISIGGYSFPSGHSVAAMVLFGSLIFITFQVVHHQLKRNLLALIYLILMLGIGLSRIYLNVHFPTDVTAGFLLGLIVLQFTTYLFYGRKIKNA
>NZ_CP021474.1|WP_002833746.1|1142502_1144920_-|leucine--tRNA-ligase
MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSEKQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSLLGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIVNIVVG
>NZ_CP021474.1|WP_094104613.1|1139886_1140606_-|16S-rRNA-pseudouridine(516)-synthase
MRVDKFLHDMNMGTRTQIRKMIKDKLIFVNDTVVKTGRVKVDPVIDEVRLKDQVIEYQQYFYFMMNKPLGVLTATEDRKQKTVMDLFNKVDLRSDLFPVGRLDKDTQGLLLITNNGQLAHDLLAPERHVDKTYEAVVTGKITDQAVEEFQKGITLKDGTTLKPAQLIIEHYSELDDQTVVKVVLKEGKYHQVRRMFGSLGEKVVTLRRTSFGPLELDVGLLPGTYRELTDDEINQLVEG
>NZ_CP021474.1|WP_094104612.1|1138440_1138845_-|universal-stress-protein
MAAFDRVIEVAKRNDAKLIIAHVVKRQHANTESVSLGFGVVSTDDDIEDILRSREDKLEVLKQKANKKGVEDVEITLKIGSPKSMLSRELPKEYDIDLIVLGATGLGKVAQVFIGSTASYVVENSPTDVMIVKN
>NZ_CP021474.1|WP_002833751.1|1137703_1138363_+|deoxynucleoside-kinase
MVIITAGMIGVGKTTLTGKIADYYGTKAFYEPVGDNPVLPLYYSDQKSYGFLLQIYFLNKRFQMIKKALTDDNNVLDRSIYEDALFTRENNKEGNITDTEFEVYMNLLDNMMSELQNLPKKAPDLMVYAETDFDTILYRIRKRGRDYEQFDNNPELESYYYKMWSAYKTWYEEYDVGPKMKIDLQKYDLSNEENVKIILKQINAKLKEVRVEEPMHKAI
>NZ_CP021474.1|WP_094104611.1|1136637_1137459_-|HAD-family-phosphatase
MIKLIVSDLDETLVGPDGNVSEENIEAIKKATQKGVKFVPNTGRGFESVQPLLETLGLKGKVNEFVISYNGGVIVENQNFDVIQANAFSFEQATQIFDITKQHLENSTHIYTLNDVYVFNEVEGDNEYIRSRGVRTIRFEHDNLDTLKDEPIFKIITMNPDFNKRKQIKAEVLDKVNFDVNATFSSDRYTEFNLKGVDKGQASLELGRHLGIKADEIMALGDNNNDVAMLKSVGLPVVVSNASASAKANAKYIAKGNYETGVAEAINKFVLGE
>NZ_CP021474.1|WP_011673188.1|1136432_1136633_-|hypothetical-protein
MQKKTYYRSSLILLILSTIIMIMTWVSSLSKTNKFIIIIIVGIILTWYIQYFSTRLTDVKKNGRKQ
>NZ_CP021474.1|WP_002833897.1|1159580_1160615_-|flippase-like-domain-containing-protein
MSRRNKVVLAVMILAGIIIFGFSLRNVNLNQMARDVVHLNMWWLLVALGCIVLYLGLEAVATKMLIQSNGDRLSWRDAIRIPLIEQLFNGITPFSSGGQPAQLVALMQNGIEGGRASSVLLMKFVVFQSMVVINFIFSLLIGFQYLEEKIRFLSWFVLFGFLIHLAVIIGLLMIMYWHNFTKRLISAIFIPIKHFVSKERYTTWKVTLNEKVDSFYQESVRMKSQWRLLAKVALVTFLQLLFYYLIPYFILLALGKSDVNIVMVTCLHVLIFMVISLFPIPGGAGGAEYGFSVIFAQFVGNNSKLVLAMMIWRILTYYFGMFAGMVATVVKPHKVNRVKVVKNE
>NZ_CP021474.1|WP_002833898.1|1160628_1161645_-|glycosyltransferase-family-4-protein
MPIKVNMFSSASKVKGQGVGSAYEELIRLLKTHFPKQIDVSINKFTKADISHYHTIDPNFYLSTFSKKRGIKVGYVHFLPETIEGSLNIPQPFRSIFYKYIISFYKRMDHIVVVNPTFIDKLVAYGISRDIITYIPNFVRKNEFYRFTEANRDAVRERLEVNNRFTVLGIGQVQERKGVKDFIKLAENNPDKYFIWAGGFSFGRLTDGYADLKQVVDNPPRNLKFTGIVDRNALVEYYNAADLFLLPSYNELFPMSVLEAFSCGVPVMLRDLELYHSIIKGYYIPTQDYEDMNTQLKLVSEDKERLNKFKQLSDEASEEYSEDHLADIWLDFYSSLTK
>NZ_CP021474.1|WP_029257843.1|1161694_1162870_-|glycosyltransferase-family-4-protein
MNIGLFTDTYFPQVSGVATSIKTLRDQLEKQGHQVYIFTTTDPKVDTNVYERNIFRFTSVPFVSFTDRRIAVSGFIRAAQLAKELNLDIVHTQTEFSLGWMGKFVAKSLKIPLIHTYHTMYEDYLHYVANGKLLKPYHVKQMTRAFCYHIDGIVAPSERVLDTIEGYGINVPIRVIPTGVNLEQYQKPNKRKQWREKLGYDESSPILLSLSRLAYEKNIQEVIDSFPAILKEVPNAQLLIVGDGPARASLENQVHDLHLEDSVQFTGEINNDHVYGFYQLADLFVSASDTESQGLTYIEALASNLKVVAKSGPYTDELLDDISLGKVFNTEEQLVAAIKDYIEHPDAYNDPAPREKKLYEISADYFGKQVVDYYSSAISTHTDLELDEDSE
>NZ_CP021474.1|WP_061812656.1|1162959_1163733_-|alpha/beta-hydrolase
MKLKLKSGAQIFFEDEGQGTPILFLTGFGGNTEIWSGQVNFFLQRGYRVIRLDYLNHGQSDRVDGELQIGDLADEVLQLVDYLQLKEPIGIGNSMGAAVLWNIINLRGWDFLNKAIFVDQSPKMLNDQQWHLGFKNLAEDNFDEVMNEPIVRPAYKHIDDFVFKNSKAIDSAYPFSQPRNRALVKGHAKKDWRFVLEQATKPVLFIMGEKSPFFDSTRTAELSALNANITVNVMKNVGHIPMAEDPTEFNRLVLQFV
>NZ_CP021474.1|WP_094104616.1|1163805_1165530_-|phosphoenolpyruvate--protein-phosphotransferase
MAGTLKGIAASDGIAIAKAYLMVDPDLSFEKKNITDVDAEIKRLHDALEKSKEELSLIKAKAAENLGAEEAEVFEAHLTILSDPELIGNIEDKIKNDTINAEEATKEVTDNFISMFEAMTDNAYMQERAADIRDVTKRLMSHLLGVELPNPALIDSEVVIVAHDLTPSDTAQLDRRYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSEKATTSVKQGEMMIVDGLTGDAIIAPTDDEIKAYQQKGEEFKAQKAEWEKLKNEKTVSKDGVHFDLAANIGTPDDLQGVLDNGGEAVGLFRSEFLYMNASELPSEDEQFEAYKKVVEGMNGKQVVVRTMDIGGDKELPYLPLPEEMNPFLGYRAIRISLDRTDLFRTQLRALLRASAFGKLAIMFPMIATVAEFKKARAIYDDERQKMVDAGQEVGEIQVGMMMEIPAAAMIADKLAKYVDFFSIGTNDLIQYSFAADRGNEKVSYLYQPYNPSLLRLIKQTIDASHAEGKWTGMCGEMAGDQIAVPILMGLGLDEFSMSATSILKARSLMKKLTTDDMKKLAEKAVTEAETNEDVIKLVQETVDNI
>NZ_CP021474.1|WP_002833902.1|1165529_1165796_-|phosphocarrier-protein-HPr
MEKRDFHVIAETGIHARPATLLVQSASKFNSDIQLTYKDKSVNLKSIMGVMSLGVGQGADVTISADGDDEADAIAALEDTMKKEGLSD
>NZ_CP021474.1|WP_094104617.1|1165941_1166130_-|hypothetical-protein
MRDYLQLLNDLKDGSIKELKITAEEFQDFQPRFMEFPERKQVIGKTDRGGVVVYHFERIKDK
>NZ_CP021474.1|WP_029257840.1|1166334_1168554_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MLCQNCQKNEASIHLYTNVNGQRTEVNLCQNCYQLLKNQRNNNINRNGGARMAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIGRDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLMKEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEEAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQKKAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQDEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGYVGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGAAAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMGARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD
>NZ_CP021474.1|WP_002833905.1|1168608_1168971_-|DUF1634-domain-containing-protein
MNAKKQEMQHVELVIGRVLQVGVYISALVILLGIGLWLFKNGSGYSGALPTRITPIFHGVLAFKPYAVLMFGIFLLILTPVLRVIVSIYAFAKEGDRLYVVITTIVLVILIIGMAIGYRG
>NZ_CP021474.1|WP_002833906.1|1168970_1169816_-|sulfite-exporter-TauE/SafE-family-protein
MASHLIILLLVGLMAGIFGAILGIGGGMIITPVLTVAMGLDIKYAIGASIIAVIATSSGATIAYLKDEMLNLRVAMFLEIATTVGAIVGAIMTGIFNSTVLFVLFGSFLVFSSWNMYRKLRRGGGEEGSTKNDRLANQLNLNGSYYDKALKKNVDYQVENVPGGSAVMFGAGLASGLLGIGSGAFKVMAMDNIMKMPLKPSSATSNLMMGVTAAASAMVYFFNGSIHADIAGPLAIGILFGAQLGSRIMQHLQPRWIRMIFIPVLLYMGLQMILKGFGVNI

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Crispr_ID: NZ_CP021474_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021474_3

1320035-1320334

TypeII

Consensus_repeat	Method
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	CRISPRCasFinder
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	CRT
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	PILER-CR

4 spacers

csn2,cas1,cas9

The CRISPR arrays of NZ_CP021474_3

>merge|NZ_CP021474|3|1320035-1320334|CRISPRCasFinder,CRT,PILER-CR
AATTTTAGGCTTACTGATTTAACACTCTTCTGAAACCAGATTATCATTAGACGTTTTAGTTTTTAAGTACTTGAACTTATTGATTTAACATTCTTCTGAAACCAAATATGCTTATGTATAGCGATGGTCGCAGTACTTGAACTTATTGATTTAACACTCTTCTGAAACTGGCTTTGCCGATTTGATTTTAGTTGCACCGTACTTGAACTTATTGATTTAACACTCTTCTGAAACTCAACAAAGACGCCATCATCAAAATGAACAGTACTTGAACTTATTGATTTAACACTCTTCTGAAAC

>NZ_CP021474|3|3|1320035-1320334|CRISPRCasFinder
AATTTTAGGCTTACTGATTTAACACTCTTCTGAAAC	CAGATTATCATTAGACGTTTTAGTTTTTAA
GTACTTGAACTTATTGATTTAACATTCTTCTGAAAC	CAAATATGCTTATGTATAGCGATGGTCGCA
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	TGGCTTTGCCGATTTGATTTTAGTTGCACC
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	TCAACAAAGACGCCATCATCAAAATGAACA
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC

>NZ_CP021474|3|1|1320035-1320334|CRT
AATTTTAGGCTTACTGATTTAACACTCTTCTGAAAC	CAGATTATCATTAGACGTTTTAGTTTTTAA
GTACTTGAACTTATTGATTTAACATTCTTCTGAAAC	CAAATATGCTTATGTATAGCGATGGTCGCA
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	TGGCTTTGCCGATTTGATTTTAGTTGCACC
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	TCAACAAAGACGCCATCATCAAAATGAACA
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC

>NZ_CP021474|3|1|1320101-1320334|PILER-CR
GTACTTGAACTTATTGATTTAACATTCTTCTGAAAC	CAAATATGCTTATGTATAGCGATGGTCGCA
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	TGGCTTTGCCGATTTGATTTTAGTTGCACC
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC	TCAACAAAGACGCCATCATCAAAATGAACA
GTACTTGAACTTATTGATTTAACACTCTTCTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021474.1\|WP_094104689.1\|1326697_1327324_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370635
NZ_CP021474.1\|WP_023440043.1\|1319251_1319902_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP021474.1\|WP_011673068.1\|1313648_1314809_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NZ_CP021474.1\|WP_002834470.1\|1317135_1318755_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP021474.1\|WP_094104692.1\|1331488_1332145_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021474.1\|WP_029257749.1\|1333229_1333622_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021474.1\|WP_094104691.1\|1329955_1331356_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP021474.1\|WP_094104693.1\|1333853_1334201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021474.1\|WP_023440044.1\|1312980_1313634_+\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|376491
NZ_CP021474.1\|WP_094104688.1\|1322426_1326506_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
NZ_CP021474.1\|WP_002834462.1\|1307753_1310114_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP021474.1\|WP_094104690.1\|1327372_1329907_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341064
NZ_CP021474.1\|WP_094104874.1\|1304485_1305886_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NZ_CP021474.1\|WP_061812556.1\|1318782_1319067_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP021474.1\|WP_002834477.1\|1332752_1333067_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379262
NZ_CP021474.1\|WP_094104687.1\|1320363_1321035_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP021474.1\|WP_151201397.1\|1306555_1307672_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP021474.1\|WP_002834469.1\|1314959_1316792_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
NZ_CP021474.1\|WP_094104686.1\|1310274_1310829_-\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NZ_CP021474.1\|WP_061812553.1\|1321313_1322219_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Function_ID	Function_description	E-value
NZ_CP021474.1\|WP_094104689.1\|1326697_1327324_+\|hypothetical-protein	gnl\|CDD\|370635	pfam09726, Macoilin, Macoilin family. The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.	5.02907e-05
NZ_CP021474.1\|WP_023440043.1\|1319251_1319902_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.39146e-10
NZ_CP021474.1\|WP_011673068.1\|1313648_1314809_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.04782e-84
NZ_CP021474.1\|WP_002834470.1\|1317135_1318755_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP021474.1\|WP_094104691.1\|1329955_1331356_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.35044e-49
NZ_CP021474.1\|WP_023440044.1\|1312980_1313634_+\|YigZ-family-protein	gnl\|CDD\|376491	pfam01205, UPF0029, Uncharacterized protein family UPF0029.	2.22012e-58
NZ_CP021474.1\|WP_094104688.1\|1322426_1326506_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	3.28381e-135
NZ_CP021474.1\|WP_002834462.1\|1307753_1310114_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP021474.1\|WP_094104690.1\|1327372_1329907_-\|M1-family-metallopeptidase	gnl\|CDD\|341064	cd09601, M1_APN-Q_like, Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1). This M1 peptidase family includes eukaryotic and bacterial members: the catalytic domains of aminopeptidase N (APN), aminopeptidase Q (APQ, laeverin), endoplasmic reticulum aminopeptidase 1 (ERAP1) as well as tricorn interacting factor F3. Aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease, preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. ERAP1, also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP), or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2, for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors. The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position. APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities. APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NZ_CP021474.1\|WP_094104874.1\|1304485_1305886_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	4.5248e-51
NZ_CP021474.1\|WP_061812556.1\|1318782_1319067_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.46498e-44
NZ_CP021474.1\|WP_002834477.1\|1332752_1333067_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	2.57449e-08
NZ_CP021474.1\|WP_094104687.1\|1320363_1321035_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.51671e-77
NZ_CP021474.1\|WP_151201397.1\|1306555_1307672_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP021474.1\|WP_002834469.1\|1314959_1316792_-\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	4.77235e-28
NZ_CP021474.1\|WP_094104686.1\|1310274_1310829_-\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.1078e-37
NZ_CP021474.1\|WP_061812553.1\|1321313_1322219_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.39506e-97

>NZ_CP021474.1|WP_023440043.1|1319251_1319902_+|CPBP-family-intramembrane-metalloprotease
MKISKSSILTLITYLIIFLLPSILNVFINLGAGFIWVETVDYLIGALLLIFISSKTNEINHIESNRKSFLYAIAWGIIGTALVILLQFVISYITIIFGSNPTSQNTATLVTLAKTNPFFILAITVGAPIMEELVFRKVLFGNLSAMFGADSTLGFTVMAIISSLAFAFMHNDSHIFLYAAIGLLFCWLYKKTGRIQTSMIAHILMNSVVILPLVIK
>NZ_CP021474.1|WP_061812556.1|1318782_1319067_-|co-chaperone-GroES
MLKPLGDRVILEAKDEEEQTVGGIVLASNAKEKSQTGKIIAVGNGTVLDNGQAVPMNVKVGDTVVYDKYAGTEVSYEDKKYLVVHEKDLVAVVE
>NZ_CP021474.1|WP_002834470.1|1317135_1318755_-|chaperonin-GroEL
MAKEIKFSEDARTKMLKGVDKLADTVKSTIGPKGRNVVLEQSYGSPTITNDGVTIAKAIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVNEGMKNVTAGANPVGIRRGIEKATSKAVEALHKMSHEVKTKDDIAQIASISSANPEVGKLIANAMEKVGNDGVITIEESRGVDTTLDVVEGMQFDRGYMSQYMVTDNDKMEANLDNPYILITDKKIGNIQDILPVLQSVVEQSRSLLIIADDITGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLEDIAILTGGTVITDDLGLNLKDVTIEQLGQSNKVTVTKDDTTIVEGAGSQEQIAERVGIIKQQISETTSDFDKEKLQERLAKLSGGVAVIRVGAATETELKEKKYRIEDALNATRAAVEEGFVPGGGTALANVISDLEDVEAEGDEATGVNIVRRALEEPVRQIAENAGEEGSVIVTKLKGQKPGVGYNAANDEWVDMVEAGIVDPTKVTRSALQNAASVSALLLTTEAVVADLPEDNPAPAAPAPGMGGMM
>NZ_CP021474.1|WP_002834469.1|1314959_1316792_-|APC-family-permease
MFSYLKRILIGKPLKTLDESGQALTKFKALALLSSDALSSIAYGTEEILSVLIVLSAAATWYSIPIAGIVLVLLFAITVSYRQIIKAYPSGGGAYVVASKNWGTSAGLVAGGSLLVDYMLTVAVSVTSGTEAITSAIPALQKYHIAIAVLIVLGIMALNLRGLRESASFLTIPVYLFIVVISLMIVVGLYNIATGQVAYHAASAVGSAVPGMTFVIFLRALSSGSSSLTGVEAISNAVPNFKKPRRKNAAGTLAIMSLILASFFAGITFLAYYSGITPSSSQTVLSQIGVTIFGHGIFYYILQLSTALILAVAANTGFSAFPMLAYNLAKDKFMPHAYMDRGDRLGYSNGIISLAAGAIVLILIFGGQTGLLIPLYAIGVFVPFTLSQSGMIVHWKREGGKKWMINASANLLGALLSAVLVICLLFLHFSNVWPYFIVMPLLLRMFYKIRKHYDEVADQLRVIEKGKVNLHDYDGSTVIVLVSNVTQVTSGAINYARSIGDYVIAMHVSFDANPEKEHKTAMEFKAEYPDVRFIDIHSSYRSITNPTLRFCDVIARRAAERNYTTTVLVPQFVPRKPWQNILHNQTGLRLRASLNSRENIIVSTYNYHLK
>NZ_CP021474.1|WP_011673068.1|1313648_1314809_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MRFEIIVSLFATMIISAILTPFVRRISFKVGAIDKPTARRVNKVPMPTMGGLAIFIAFNFSLFFLLRNQIPNPQFYGIFFGECIILVTGIIDDIFELRPIQKMIGILLAALAVYLFANVRMTTLTFPFIGIVNFGWFSLPITLLWIAAITNAINLLDGLDGLATGVTIIALFTTGFTGLFFLPSTNIYIVIMIFTLVAAEIGFLPYNFFPARIYLGDTGALFIGFMISIFSLSGLKNATFITILIPVMILGVPLTDTVYAILRRLLNKESISHADKRHLHHRLMQMGLTHRQTVLVIYGISLIFSFIALLYPVSTLWGSVLLTIGILIGIEIFVEAIGLVGENRTPMLNWIRKLVRSNTSKVDSNEFKEENTLKDKVRTRSERHKK
>NZ_CP021474.1|WP_023440044.1|1312980_1313634_+|YigZ-family-protein
MKPILSVKENFKIEQDIKKSRFITRIIPIQSEEEANQLLTEIRTTEAKANHNCFAYILGDQQDIQRASDDGEPSGTAGAPILEVLKRENLTNVLIVVTRYFGGIKLGAGGLIRAYGSSTSLAVNNAALIQLVDQELLSIKLDYQNNDQLVYYLEQHHLNQLETEYTTQVTTTISISKEQLEPLKKELIGLFSGNVAFKDLGTERVQIPYQKNEDDND
>NZ_CP021474.1|WP_094104686.1|1310274_1310829_-|ribosome-associated-translation-inhibitor-RaiA
MLDFNVRGENIEVTEAIRDYVEKRIGKIEKYFEQGANPKAHVNLKVYQDKTAKVEVTIPLPYLVLRAEETSPDLYASVDLVTDKLERQLRKYKTKINRKSRETGYKGVEIPSGDMVENEEETSQFDIVRTKQVSLKPMGSEEAILQMDMLGHNFFIYEDAESGSVDIVYRRRDGRYGLIESAND
>NZ_CP021474.1|WP_002834462.1|1307753_1310114_-|preprotein-translocase-subunit-SecA
MANILKKWVESDARELKRLGKKADKIEALKEEMEQLNDEKLKAKTTEFKERLQNGETLDDILVEAFAVAREAAKRVLGLFPFRVQLIGGMVLHGGNIAEMKTGEGKTLTATLPVYLNALGGKGVHVVTVNEYLAERDSSEMGELYKWLGLTVGVNSSEMTPDQKREAYNCDITYSTNSEIGFDYLRDNMVVYKEDMVQRPLNFALIDEVDSILIDEARTPLIISGQTEPTVTLYERADRYVKTLADGDYTIDWESKSISLTENGIRRAENFFKTDNLYDVENSALNHHIDQALRANYIMTKDKDYVVSDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEHVEIQDGAKTMANITYQNLFRMYRKLSGMTGTARTEAEEFREIYNMEVTTIPTNRPVARDDRPDLLYPTLESKFKAVVKEIRDLHIKGQPVLVGTVAVETSEYLSRLLDREGIPHVVLNAKNHAREAEIVTNAGQKGAVTIATNMAGRGTDIKLGPGVVELGGLAVIGTERHESRRIDNQLRGRSGRQGDVGMSQFYLSLEDDLMIRFGSERIKDLLSRMKIADEDAVIRSGLISRQVESAQKRVEGNNYDARKNVLQYDDVMRAQREVIYAERQQVIMEETSLKDVLMPMVDRTIDRVVDAHTQKTQKNFDLETIVEFARTALVSDKDIHQADVEGMSAKEIKDYLKQLADQMYIEKEKALYDPAQILEFEKVVILRVVDQHWTDHIDAMDQLRQSVGLRGYGQLNPLVEYQQEGYRMFNEMITDIEYETTRLFMKSEIRQNLQR
>NZ_CP021474.1|WP_151201397.1|1306555_1307672_-|peptide-chain-release-factor-2
MELVEAKHQIEDMKKEVADFGRSLDLDALNESISVNEAKMAEPNFWDNQEQAQIVINENNELKQKYDNFKNLTDHVENLEVTAELLEMEDDPDVQSEFESELAATAKLLQDYRLGLLLNGKYDANNAIVEIHPGAGGTESQDWGSMLLRMYTRWAEQHQFKVQIEDYQAGEVAGISSVTMRIVGHNAYGYLRSEKGVHRLVRLSPFDSAGRRHTSFASVDVMPELDDSVEVNINQDDLRVNVYRSSGAGGQHINKTSSAVRITHLPTGIVVASQAERSQLQNRATAMSMLKAKLFELEEQKKAEEKAKIEGIQLEIGWGSQIRSYVFHPYSMVKDHRSNFETANVQGVMDGDLDDFINAYLQWKLKEDNPK
>NZ_CP021474.1|WP_094104874.1|1304485_1305886_-|two-component-sensor-histidine-kinase
MRGFGYEFVSKKAIKRTVQFGFASLIGNAFMAFLVYKLIVKENPRVTKVDMTLLIAVILLITVIEIIVFWSNQKKIIERQKLFRKNLEEVIKGNHVPKIQLDPEDPFYKLSKVVNEIGTHERHQIHVLRNQQSELTAIMDNLPVGVLVINRHRELQVANTYAINHLGITGLDVPHPYTMDIRDHELSELVDNVFRTRQSTTKTIKLDGDQPYIYETTVVYSPKVHHKFEIIVLLYDATETVRSKQIERDFVNNASHELRTPITSIAGFADTLLNGAKDDPETLDNFLRIIKAESDKLVQLTDDILTMSRVKSGERERKEINLHKYVDQQLKLVESNISSMNLHVENNIPADVNEEVIENDLFQIVKNLITNAISYNRKGGKIKIDYGSHHDRWKLVVSDTGIGIPLGQTDRVFERFYRVNKATKGGTGLGLAIVKEAVDDMNGSVRIESDEDSGTTVIVKFKRDIN
>NZ_CP021474.1|WP_094104687.1|1320363_1321035_-|type-II-A-CRISPR-associated-protein-Csn2
MKITYKTHDNLEINSGQISILGTNSPTVYTDIIQGLQDENEKISIVDENYSALEIAHAIDWIGDVGTQNLVLTKYLRQIEKLFLRSVTDEQQNKIHDEINRIFNIVSEQLFLLDLPIEVNFDFDLKKLFKYCGIRFDPILISKPYGIIETIIKIHETSNLDSCIALTNVAHYLTSVEFEELSQLVKETNQKILLIEFTEIEEQNFYRNAEFYYIDTDFIDWHN
>NZ_CP021474.1|WP_061812553.1|1321313_1322219_-|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSIIITQHAKLSYSSRTMIVQTNDGINQIPIDDISLLLISTTQAVITTALISELSKKNVKIIFTDDTHKPISETYGYYPNHRSAGLLREQLNWEIGRSQVLWTKVVASKLINQINVLKLQNVKTSSLEDELNKLELNDITNGEAVIARKYFPLLFEDGFSRRNGSVINTALNYGYSILLSTINQEIVSNGYLTYIGIHHDNEENQFNLASDLMEPFRPIVDFWLANKKFNEFTPDVKYGLVELLSLEIKYNGKNTLLRNAITIHVRNCLKYLSNKEQNIKIEMELLDEVPNHAINDNV
>NZ_CP021474.1|WP_094104688.1|1322426_1326506_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MEKVPYNIGLDIGTSSIGFAATDNLNKPIRAKGKTVIGVRLFEEGKTAADRRGFRTTRRRLSRRKWRLRLLDEIFDKEMAKVDNTFFARLKESNLSPKDANKKYLGSLLFPEKKDFKFYEDYPTIYHLRYALMHEKRQFDIREVYLAMHHIIKYRGNFLNSAPMNSFKTQDFDFVAKFEKLNELFESIDAEHETKFDIENISKFRDIMLNQDIRKLDRKKQAAKILILDSTDKTAKKINNKIATAVANSALGYKFALDAILKLDVEESKDWSISLNDEEIDSILDNLTSDLDAERIEIIEILRDLYSHIALNEIVPNGQSLSKSMMDKYDKHHADLDVLKKVISNMDDRKKAKSLKNIYNQYVGKTNDKVLDKDEFYKQIQKNLDKSEDAMKIVNEIELDQFMPKQRTSQNGVIPHQLHQKELDEIIENQKQYYPFLAEPNPNEKRKPHAQFKLDELIAFKIPYYVGVLITKEEQQAQSGAEFAWMKRKQDGVITPWNFDEKVDRMASANEFIRRMTTKDTYLLGEDVLPDESLIYQKFKVLNELNNVKVNDKKLTVADKQDIFTDLFKKQKTVSVSKLQKYFVTEKHYLTEPTIKGLSDTKKFSNSLSTYIDFEKIFGNEILADQNKQNDLEKIIEWSTIFEDRKIFEDKLHEIEWLTEKQIKAIRRYRGWGRLSKKLLVDLRNNEGKSILDELWRTNDNFMQIQAREEFAKSIVEANQKLMNLGGAASVQNTVESTLEDAYTSPQNKKAIRQVIKVVEDIVKAVGYAPEKITIEFTRGADKNPRRTQNRQKQIMEVYKTAAKEIVDATLKGQLENEEKLTDKLYLYFTQLGKDIYSGETINIDQLNNYDIDHILPQAFIKDDSLDNRVLTSRALNNGKSDSVPVNQFGANMKSFWMRLQAHGLISKRKLNNLMTDPDSIGKYTMQGFVRRQLVETSQVIKLTANILGAIYGENTDIVEIPAKLTHQMREKFNLYKVREVNDYHHAFDAYLTTFVGNYLFKRYPKLRPYFVYGDFKMTDNALKGMRRFNFLHDLKDDEVLVDNETGEVLWEGQKSIEELKKIYGYKFMLTTHEAYINNGAMYDQTVYPAKSNKKLIPSKNNRPTNIYGGFSGNKDAYLAIVKILGKKGDTYKVVGVPRRFSDELLNAYNDDYSEYLNKLHDVLVTQFTKKQRNKKTGKIIKKIENFEIVVGKVNYRQRIIDRNQSFMLGSSTYKYNTKQLVLTESSMKILSNFKHASDDNLNLVYDEILEKVNESFELYDKNGFRKKLNNNIDKFRKLPCKSIFEKNKLISVGKCEILFQILNGLHANATMGDLKGIGFSTPFGFMQDASGIKLNKDSMLLYQSPTGLFERKVKLSDL
>NZ_CP021474.1|WP_094104689.1|1326697_1327324_+|hypothetical-protein
MKKIASIALLALVPLTLASCGSGNQKSGSQSSNATSKTEKVSKKASSKASSKKDQEASSSSKASSDSSSSAKDDQTSSSVASASSSTSKASNSAISSSSKSESNHNSSNKTNSNNLSRADLTAAEQQNNHQPLADETIQTSEAAINLVKAKYGDKGWKVAYSSVGKSSPIYFHVTSDHDGSYYVYANGVVQNAGGDLSDHASEIQNIK
>NZ_CP021474.1|WP_094104690.1|1327372_1329907_-|M1-family-metallopeptidase
MSKITRLYDLFQPEHYDIFLDISRETKHFRGKTVIQGIAQQTEIALHQKDLEVKVVYVNDEKTPFEIDSANEVIRLQLSQAGNVTLTVEYEAELTDSMMGIYPSYYEVDGVQKQLVGTQFETTFARQAFPGIDEPEAKATFDLAIKYDEHDGETILSNMPEIKVVDGIHYFDTTVKMSTYLIAFAFGDLQSKMTKTTSGVQVGVFATKAHQAQELDFALDIAKRSIEFYEEFYHIAYPLPHSWQLALPDFSAGAMENWGLVTYREAYLLLDPKNTALETKQLVATVIAHELAHQWFGDLVTMQWWDDLWLNESFANMMEYVAIDAIEPDWHIWEMFQTSDVPAALQRDATDGVQSVHVQVQNPAEIDALFDGAIVYAKGARMLVMVRALIGDDALRTGLKQYFNNHQYGNAKGADLWTALGDAAGIDVGAIMHSWLEQPGYPVVNVEVVDGQLTISQQQFFIGEGQNAGRQWQIPLKGNYEVVPQILDQPTLSLGDYQQLRNENGQPFRLNVGNESHFIVHYAKDLLADILGALDQLGAIDQLQILQDLRLLAEGNQISYAEIVPLLEKFADSSSAVVNDVLYRLAGDLKKFVQPDSEEEANLQKLFNQLSAKQVQRLGWKPRATESNDDQLTRPYVLGAALYAKNPEAILAAHELFEQNQNQLSNLSADIRSYVLSNEVKNFNNERLFNQLMEQYRQSTDPSYKADLSRALTATTDEKQIKAIIEKFEDASTIKPQDLRAWFQGLLANAKGQQLTWDWIRNDWKWLEDTVGGDMEFNTFITVIANIFRTPARLEEFKAFFEPKLQTPGLTREITMDIKVIEGRVKLIQAEKVAVNTAIEKIIA
>NZ_CP021474.1|WP_094104691.1|1329955_1331356_-|MFS-transporter
MQESSTKKSNPMVVVAIVALMSFMGVLTETSMNVTFPALMREFKVSLSTVQWVTAGYLLMAALVMLTSAYMKRRFTNRQLFVAAAILFGLGDVICGAALNFWVLLVGRLIQAGCVGLCTPLMINIILEVVPQHKLGTYIGLANLIILIAPAMGPTFGGAVVAFASWRMIFWGTLPIALILMVLGSKKIKQYTPTQKQYAFDWTRFILLGLALVVLIVGLNNLGSGAYISFIVLLLLSIGLTTLFVKKSKNATKALFSLDVFKNKAFLFSFLPYIMLQFANVGINFLLPNYVQDVFQATSLIGGLILLPGSLLNGFGQPVYGWMLDNFGGKLPLYMGDILFTLALASLALWGPHMGVLGITIAYLIFAIGRSMAFGNSVAYGLKHINQELQNDANALYNTGQQVAGAIGTTVLALMMGSVHHPGYTRAQNISAGSGWAFILLVILGLIILGFFHRLVNLDKQIKQTN
>NZ_CP021474.1|WP_094104692.1|1331488_1332145_-|hypothetical-protein
MGIRIDITGKKFGKLVAKYPSGKAKNGNTKWHCVCECGQEKDVELQHLRSGGTKSCGNCSRMKYDLQGKRFARLTVLGRADKVSSNGNIYWLCRCVCGKMIEADSYRLRTGNVKSCGCLRKEKAAQTIRKNAATAEQIGNSNAFKDRNGNPVQAVNIGARNTSGVIGVSFDHPSQKWVARMMHKGDLVLNATFLDFEEAVEARRRVEHKYLKNLSRTN
>NZ_CP021474.1|WP_002834477.1|1332752_1333067_-|helix-turn-helix-transcriptional-regulator
MVKRFQFIRKNRKRKNLTIEQLAEKADVSIDLVARLERGEREDVSISKLESILHALDLELGDVFKHSKLDKKSDEFVRKFLKLDAETREKYTDIFLSIIDLKNE
>NZ_CP021474.1|WP_029257749.1|1333229_1333622_+|hypothetical-protein
MSNILISLLTLIAILFCWKSLYQNPARQIAGRKFYITKEYPTTYANAVDNLDHATIQFKKDGSIKYEVINDYSNDKWTINGHKVEMGNIADPDRTYIDLNDERQIDGHTFYEIKFEDDINIFQYFLVSEN
>NZ_CP021474.1|WP_094104693.1|1333853_1334201_-|hypothetical-protein
MNVNTKKWGIIGTIVVVVLIAIFMVTRPTRLSGKYVANTGSSLVFKGDKFEEFENGRNTHEGTYKIEDSEIKMKFSDGSGTTTAKLTKDKQSFSLKSTGNAFADLFAQNIKYTKE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MF041990	Lactobacillus phage phiEF-1.1, complete genome	20276-20305	5	0.833
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MF417961	Uncultured Caudovirales phage clone 10S_15, partial genome	8684-8713	5	0.833
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MN694096	Marine virus AFVG_250M214, complete genome	6030-6059	6	0.8
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MN694078	Marine virus AFVG_250M213, complete genome	32471-32500	6	0.8
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	AP014373	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S42-C24, * SEQUENCING IN PROGRESS *	3186-3215	6	0.8
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MN693931	Marine virus AFVG_250M215, complete genome	32477-32506	6	0.8
NZ_CP021474_3	3.3\|1320203\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320203-1320232	30	NZ_CP031031	Runella sp. SP2 plasmid pSP2_1, complete sequence	12920-12949	7	0.767
NZ_CP021474_3	3.3\|1320203\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320203-1320232	30	NZ_CP014003	Synechococcus sp. PCC 73109 plasmid unnamed5, complete sequence	162479-162508	7	0.767
NZ_CP021474_3	3.3\|1320203\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320203-1320232	30	NZ_CP016489	Synechococcus sp. PCC 8807 plasmid unnamed6, complete sequence	31907-31936	7	0.767
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MN038175	Panteoa phage Phynn, complete genome	114230-114259	7	0.767
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	MN855792	Siphoviridae sp. isolate 87, complete genome	16890-16919	7	0.767
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP041590	Acinetobacter baumannii strain J9 plasmid pJ9-3, complete sequence	73256-73285	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	CP033569	Acinetobacter pittii strain 2014N21-145 plasmid p2014N21-145-1, complete sequence	95389-95418	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP033130	Acinetobacter wuhouensis strain WCHAW010062 plasmid pOXA23_010062, complete sequence	203986-204015	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	CP033531	Acinetobacter pittii strain 2014S07-126 plasmid p2014S07-126-1, complete sequence	182790-182819	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP042557	Acinetobacter baumannii strain E47 plasmid pE47_001, complete sequence	322669-322698	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP010351	Acinetobacter johnsonii XBB1 plasmid pXBB1-9, complete sequence	12848-12877	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP029396	Acinetobacter defluvii strain WCHA30 plasmid pOXA58_010030, complete sequence	235199-235228	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP048828	Acinetobacter baumannii strain ABF9692 plasmid pABF9692, complete sequence	99261-99290	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP032285	Acinetobacter sp. WCHA55 plasmid pOXA58_010055, complete sequence	369421-369450	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP042365	Acinetobacter pittii strain C54 plasmid pC54_001, complete sequence	232229-232258	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_MK134375	Acinetobacter baumannii strain 34AB plasmid p34AB, complete sequence	155693-155722	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP038010	Acinetobacter haemolyticus strain TJR01 plasmid pAHTJR1, complete sequence	285078-285107	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP043053	Acinetobacter pittii strain AP43 plasmid pAP43-OXA58-NDM1, complete sequence	201107-201136	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_MH220287	Acinetobacter ursingii strain RIVM0061 plasmid pRIVM0061_IMP-4_171109_B01, complete sequence	234319-234348	8	0.733
NZ_CP021474_3	3.2\|1320137\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320137-1320166	30	NZ_CP043309	Acinetobacter johnsonii strain Acsw19 plasmid pAcsw19-2, complete sequence	67010-67039	8	0.733
NZ_CP021474_3	3.4\|1320269\|30\|NZ_CP021474\|CRISPRCasFinder,CRT,PILER-CR	1320269-1320298	30	CP052389	Klebsiella pneumoniae strain C17KP0052 plasmid pC17KP0052-1	146083-146112	8	0.733
NZ_CP021474_3	3.1\|1320071\|30\|NZ_CP021474\|CRISPRCasFinder,CRT	1320071-1320100	30	NZ_CP032858	Bacillus subtilis subsp. subtilis strain 2RL2-3 plasmid unnamed1, complete sequence	9139-9168	9	0.7
NZ_CP021474_3	3.1\|1320071\|30\|NZ_CP021474\|CRISPRCasFinder,CRT	1320071-1320100	30	NZ_CP032873	Bacillus subtilis subsp. subtilis strain 2KL1 plasmid unnamed1, complete sequence	30172-30201	9	0.7
NZ_CP021474_3	3.1\|1320071\|30\|NZ_CP021474\|CRISPRCasFinder,CRT	1320071-1320100	30	NZ_CP026534	Bacillus velezensis strain DKU_NT_04 plasmid p1_DKU_NT_04, complete sequence	122284-122313	9	0.7

1. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MF041990 (Lactobacillus phage phiEF-1.1, complete genome) position: , mismatch: 5, identity: 0.833

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
tcaacaaacactccatcatcaaaatgcgta	Protospacer
******** ** ************** ..*

2. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MF417961 (Uncultured Caudovirales phage clone 10S_15, partial genome) position: , mismatch: 5, identity: 0.833

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
tcaacaaagacaccatcatcaagatttacc	Protospacer
***********.**********.**  **

3. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MN694096 (Marine virus AFVG_250M214, complete genome) position: , mismatch: 6, identity: 0.8

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
taaacaaagacgcaatcatgaaaatgtatc	Protospacer
* *********** ***** ****** *.

4. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MN694078 (Marine virus AFVG_250M213, complete genome) position: , mismatch: 6, identity: 0.8

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
taaacaaagacgcaatcatgaaaatgtatc	Protospacer
* *********** ***** ****** *.

5. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to AP014373 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S42-C24, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
tgattgatgacgccatcatcaaaaggaaca	Protospacer
* * ..* **************** *****

6. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MN693931 (Marine virus AFVG_250M215, complete genome) position: , mismatch: 6, identity: 0.8

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
taaacaaagacgcaatcatgaaaatgtatc	Protospacer
* *********** ***** ****** *.

7. spacer 3.3|1320203|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP031031 (Runella sp. SP2 plasmid pSP2_1, complete sequence) position: , mismatch: 7, identity: 0.767

tggctttgccgatttgatttt---agttgcacc	CRISPR spacer
aggctttgccaatttgattttacaatttgt---	Protospacer
 *********.**********   * ***.

8. spacer 3.3|1320203|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014003 (Synechococcus sp. PCC 73109 plasmid unnamed5, complete sequence) position: , mismatch: 7, identity: 0.767

tggctttgccgatttgattttagttgcacc	CRISPR spacer
tgggtttgccaatttgattttaggtcaaat	Protospacer
*** ******.************ *  * .

9. spacer 3.3|1320203|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016489 (Synechococcus sp. PCC 8807 plasmid unnamed6, complete sequence) position: , mismatch: 7, identity: 0.767

tggctttgccgatttgattttagttgcacc	CRISPR spacer
tgggtttgccaatttgattttaggtcaaat	Protospacer
*** ******.************ *  * .

10. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MN038175 (Panteoa phage Phynn, complete genome) position: , mismatch: 7, identity: 0.767

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
tcgttaaagacggcatcatcaatatgaagg	Protospacer
**. .******* ********* ***** .

11. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to MN855792 (Siphoviridae sp. isolate 87, complete genome) position: , mismatch: 7, identity: 0.767

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
tcaacaaacacgccatcttcaaagtagatg	Protospacer
******** ******** *****.*..*..

12. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP041590 (Acinetobacter baumannii strain J9 plasmid pJ9-3, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

13. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to CP033569 (Acinetobacter pittii strain 2014N21-145 plasmid p2014N21-145-1, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

14. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP033130 (Acinetobacter wuhouensis strain WCHAW010062 plasmid pOXA23_010062, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

15. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to CP033531 (Acinetobacter pittii strain 2014S07-126 plasmid p2014S07-126-1, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

16. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP042557 (Acinetobacter baumannii strain E47 plasmid pE47_001, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

17. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP010351 (Acinetobacter johnsonii XBB1 plasmid pXBB1-9, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

18. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP029396 (Acinetobacter defluvii strain WCHA30 plasmid pOXA58_010030, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

19. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP048828 (Acinetobacter baumannii strain ABF9692 plasmid pABF9692, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

20. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP032285 (Acinetobacter sp. WCHA55 plasmid pOXA58_010055, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

21. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP042365 (Acinetobacter pittii strain C54 plasmid pC54_001, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

22. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_MK134375 (Acinetobacter baumannii strain 34AB plasmid p34AB, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

23. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP038010 (Acinetobacter haemolyticus strain TJR01 plasmid pAHTJR1, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

24. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP043053 (Acinetobacter pittii strain AP43 plasmid pAP43-OXA58-NDM1, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

25. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_MH220287 (Acinetobacter ursingii strain RIVM0061 plasmid pRIVM0061_IMP-4_171109_B01, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

26. spacer 3.2|1320137|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP043309 (Acinetobacter johnsonii strain Acsw19 plasmid pAcsw19-2, complete sequence) position: , mismatch: 8, identity: 0.733

caaatatgcttatgtatagcgatggtcgca	CRISPR spacer
tacctatgcttatgtatagggatggaagtt	Protospacer
.*  *************** *****  *.

27. spacer 3.4|1320269|30|NZ_CP021474|CRISPRCasFinder,CRT,PILER-CR matches to CP052389 (Klebsiella pneumoniae strain C17KP0052 plasmid pC17KP0052-1) position: , mismatch: 8, identity: 0.733

tcaacaaagacgccatcatcaaaatgaaca	CRISPR spacer
tcaacaaagaagcgatcatcaaagcggttt	Protospacer
********** ** *********..*. .

28. spacer 3.1|1320071|30|NZ_CP021474|CRISPRCasFinder,CRT matches to NZ_CP032858 (Bacillus subtilis subsp. subtilis strain 2RL2-3 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.7

cagattatcattagacgttttagtttttaa	CRISPR spacer
attattgtcattaggcgttttagtttccgg	Protospacer
   ***.*******.***********....

29. spacer 3.1|1320071|30|NZ_CP021474|CRISPRCasFinder,CRT matches to NZ_CP032873 (Bacillus subtilis subsp. subtilis strain 2KL1 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.7

cagattatcattagacgttttagtttttaa	CRISPR spacer
attattgtcattaggcgttttagtttccgg	Protospacer
   ***.*******.***********....

30. spacer 3.1|1320071|30|NZ_CP021474|CRISPRCasFinder,CRT matches to NZ_CP026534 (Bacillus velezensis strain DKU_NT_04 plasmid p1_DKU_NT_04, complete sequence) position: , mismatch: 9, identity: 0.7

cagattatcattagacgttttagtttttaa	CRISPR spacer
attattgtcattaggcgttttagtttccgg	Protospacer
   ***.*******.***********....

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

801237 : 842587

Lactobacillus_phage(75.76%)

head,protease,portal,integrase,capsid,terminase,holin,tail

attL 793067:793082|attR 816751:816766

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
793067:793082	attL	NA	NA	NA	NA
WP_094104432.1\|801237_802311_-\|integrase	site-specific integrase	Q9ZXG6	Leuconostoc_phage	6.8e-45	36.0
WP_094104433.1\|802462_802750_-	hypothetical protein	NA	NA	NA	NA
WP_094104434.1\|803103_803949_-	hypothetical protein	A0A1S5SBK8	Streptococcus_phage	1.4e-08	22.3
WP_094104435.1\|804169_804589_-	hypothetical protein	NA	NA	NA	NA
WP_094104436.1\|804585_805065_-	hypothetical protein	NA	NA	NA	NA
WP_060743628.1\|805187_805697_-	hypothetical protein	NA	NA	NA	NA
WP_094104437.1\|805752_806058_-	hypothetical protein	D2KRD5	Lactobacillus_phage	1.9e-16	50.0
WP_023440064.1\|806070_806412_-	helix-turn-helix transcriptional regulator	Q8W5Y0	Listeria_phage	6.1e-16	44.0
WP_023440065.1\|806679_806871_+	hypothetical protein	NA	NA	NA	NA
WP_094104438.1\|806871_807330_+	hypothetical protein	NA	NA	NA	NA
WP_094104439.1\|807326_807527_+	hypothetical protein	NA	NA	NA	NA
WP_151201389.1\|807480_807717_-	hypothetical protein	NA	NA	NA	NA
WP_094104441.1\|807773_808541_+	phage antirepressor KilAC domain-containing protein	A0A0A7DN31	Lactobacillus_phage	2.3e-63	56.0
WP_094104442.1\|808597_808804_+	hypothetical protein	NA	NA	NA	NA
WP_094104443.1\|808867_809071_+	DUF2829 domain-containing protein	NA	NA	NA	NA
WP_094104444.1\|809211_809421_+	hypothetical protein	NA	NA	NA	NA
WP_094104445.1\|809734_810001_-	hypothetical protein	NA	NA	NA	NA
WP_094104446.1\|810224_810686_+	chromosome segregation protein SMC	NA	NA	NA	NA
WP_094104447.1\|810682_811339_+	ERF family protein	A0A2H4JA34	uncultured_Caudovirales_phage	8.4e-22	33.7
WP_061812702.1\|811341_811740_+	single-stranded DNA-binding protein	D6PSU2	Lactobacillus_phage	4.3e-37	56.8
WP_094104448.1\|811750_812428_+	hypothetical protein	E9LUU3	Lactobacillus_phage	2.6e-82	64.8
WP_094104449.1\|813151_813970_+	ATP-binding protein	O03914	Lactobacillus_phage	3.2e-63	50.0
WP_094104450.1\|814086_814497_+	RusA family crossover junction endodeoxyribonuclease	A0A0P0IXM5	Lactobacillus_phage	5.4e-43	60.3
WP_094104451.1\|814493_814712_+	hypothetical protein	NA	NA	NA	NA
WP_002833141.1\|814849_815044_+	hypothetical protein	NA	NA	NA	NA
WP_094104452.1\|815043_815397_+	hypothetical protein	O03921	Lactobacillus_phage	3.7e-24	55.2
WP_094104453.1\|815396_815690_+	hypothetical protein	NA	NA	NA	NA
WP_094104454.1\|815690_816236_+	DUF1642 domain-containing protein	A0A141E054	Streptococcus_phage	1.2e-08	33.3
WP_094104455.1\|816228_816657_+	hypothetical protein	NA	NA	NA	NA
WP_094104456.1\|816861_817080_+	hypothetical protein	NA	NA	NA	NA
816751:816766	attR	NA	NA	NA	NA
WP_094104457.1\|817360_817687_+	hypothetical protein	NA	NA	NA	NA
WP_094104458.1\|817687_817978_+	hypothetical protein	NA	NA	NA	NA
WP_151201390.1\|817952_818345_+	hypothetical protein	NA	NA	NA	NA
WP_094104460.1\|818419_818836_+	RNA polymerase subunit sigma-70	O03925	Lactobacillus_phage	9.4e-11	30.9
WP_094104461.1\|819366_819822_+	HNH endonuclease	B8R694	Lactobacillus_phage	2.8e-24	39.0
WP_094104462.1\|819818_820100_+	hypothetical protein	NA	NA	NA	NA
WP_094104463.1\|820321_820786_+\|terminase	phage terminase small subunit P27 family	E9LUP8	Lactobacillus_phage	1.5e-46	62.7
WP_094104464.1\|820785_822660_+\|terminase	terminase large subunit	A0A0M7RDK9	Lactobacillus_phage	1.4e-141	41.4
WP_094104466.1\|822972_823974_+\|portal	phage portal protein	A0A0M9JJ63	Lactobacillus_phage	6.5e-50	35.5
WP_094104862.1\|823957_824521_+\|head,protease	HK97 family phage prohead protease	B8R651	Lactobacillus_phage	6.9e-41	49.1
WP_094104467.1\|824548_825880_+\|capsid	phage major capsid protein	D2KRA9	Lactobacillus_phage	1.0e-79	42.6
WP_094104468.1\|825962_826175_+	hypothetical protein	A0A0M9JJ52	Lactobacillus_phage	2.1e-06	44.8
WP_094104469.1\|826494_826854_+\|head	phage head closure protein	A0A2P0ZLF0	Lactobacillus_phage	1.1e-15	39.5
WP_094104863.1\|826873_827269_+\|tail	phage tail protein	A0A286QQY0	Streptococcus_phage	1.0e-30	56.9
WP_094104470.1\|827268_827643_+	DUF806 family protein	A0A2P0ZLF4	Lactobacillus_phage	3.4e-12	30.5
WP_094104471.1\|827656_828262_+	hypothetical protein	Q9AZL7	Lactococcus_phage	1.0e-34	41.6
WP_094104472.1\|828398_828812_+	hypothetical protein	NA	NA	NA	NA
WP_094104473.1\|829020_830664_+	hypothetical protein	A0A2I6QR39	Streptococcus_phage	2.1e-74	49.5
WP_094104474.1\|830971_831442_+	hypothetical protein	Q6J1X5	Lactobacillus_phage	3.0e-05	61.0
WP_094104475.1\|831554_833648_+	peptidoglycan DD-metalloendopeptidase family protein	B8R657	Lactobacillus_phage	5.4e-46	55.5
WP_094104476.1\|833649_835419_+	hypothetical protein	U3PDQ7	Lactobacillus_phage	1.6e-19	23.0
WP_094104477.1\|835436_837098_+	hypothetical protein	A0A1I9KKS3	Lactobacillus_phage	6.5e-71	34.3
WP_151201391.1\|837013_837955_+	hypothetical protein	A0A0A7DMR8	Lactobacillus_phage	6.2e-18	29.0
WP_094104479.1\|837951_840249_+	hypothetical protein	A0A1S5RCP2	Lactobacillus_phage	8.0e-27	45.8
WP_094104480.1\|840245_840476_+	hypothetical protein	NA	NA	NA	NA
WP_094104481.1\|840653_840902_+	hypothetical protein	A0A0P0I3K6	Lactobacillus_phage	1.6e-05	47.4
WP_094104864.1\|840943_841228_+	hypothetical protein	NA	NA	NA	NA
WP_094104482.1\|841227_841479_+\|holin	holin	NA	NA	NA	NA
WP_094104483.1\|841462_842587_+	N-acetylmuramoyl-L-alanine amidase	A0A0P0I386	Lactobacillus_phage	8.8e-96	51.4

DBSCAN-SWA_2

934287 : 995181

Lactobacillus_phage(51.61%)

protease,plate,portal,capsid,tRNA,terminase,holin,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_061812052.1\|934287_935187_-\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_002833619.1\|935325_935676_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_094104510.1\|935692_938413_-	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	9.2e-22	25.1
WP_011673321.1\|938727_939021_-	YlxR family protein	NA	NA	NA	NA
WP_002833615.1\|939042_940131_-	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_002833614.1\|940144_940621_-	ribosome maturation factor RimP	NA	NA	NA	NA
WP_094104511.1\|940740_945054_-	PolC-type DNA polymerase III	A0A0K2SUJ2	Clostridium_phage	1.8e-19	35.1
WP_002833612.1\|945147_946863_-\|tRNA	proline--tRNA ligase	A0A2K9L6B6	Tupanvirus	2.2e-05	23.6
WP_061812048.1\|946890_948153_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_061812071.1\|948176_948962_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_094104512.1\|948972_949722_-	isoprenyl transferase	R9W0U9	Flavobacterium_phage	3.0e-23	41.3
WP_094104513.1\|949979_950501_-	ribosome recycling factor	NA	NA	NA	NA
WP_002833607.1\|950538_951264_-	UMP kinase	NA	NA	NA	NA
WP_002833606.1\|951417_952296_-	elongation factor Ts	NA	NA	NA	NA
WP_002833605.1\|952411_953194_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_094104514.1\|953345_954341_-	D-2-hydroxyacid dehydrogenase	M1I4S0	Paramecium_bursaria_Chlorella_virus	2.2e-45	32.9
WP_002833603.1\|954461_954749_-	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_094104515.1\|954729_955485_-\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
WP_094104516.1\|955559_956204_+	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_094104517.1\|956215_956437_-	YneF family protein	NA	NA	NA	NA
WP_002833598.1\|956507_956756_-	DUF896 domain-containing protein	NA	NA	NA	NA
WP_094104518.1\|956889_957519_+	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	1.2e-12	45.1
WP_061812042.1\|958235_959402_-	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
WP_061812041.1\|959562_960939_-	amino acid permease	NA	NA	NA	NA
WP_094104519.1\|962229_963354_-	N-acetylmuramoyl-L-alanine amidase	A0A0P0IX40	Lactobacillus_phage	7.0e-101	54.3
WP_094104520.1\|963337_963577_-\|holin	holin	NA	NA	NA	NA
WP_094104521.1\|964053_964365_-	hypothetical protein	NA	NA	NA	NA
WP_094104522.1\|964376_965408_-	hypothetical protein	NA	NA	NA	NA
WP_094104523.1\|965407_967096_-\|plate	phage baseplate upper protein	O03968	Lactobacillus_phage	3.0e-63	52.8
WP_094104524.1\|967095_967392_-	hypothetical protein	NA	NA	NA	NA
WP_094104525.1\|967381_967708_-	hypothetical protein	NA	NA	NA	NA
WP_094104526.1\|967697_968834_-	hypothetical protein	O03938	Lactobacillus_phage	1.3e-54	40.9
WP_094104527.1\|968843_969641_-\|tail	phage tail family protein	D2KRB8	Lactobacillus_phage	1.8e-58	42.6
WP_094104528.1\|969693_970986_-	peptidoglycan DD-metalloendopeptidase family protein	D2KRB7	Lactobacillus_phage	3.9e-39	40.3
WP_094104529.1\|971063_971549_-	hypothetical protein	A7DYB8	Streptococcus_phage	2.8e-22	55.8
WP_094104530.1\|971542_972085_-	hypothetical protein	NA	NA	NA	NA
WP_094104531.1\|972402_972993_-	hypothetical protein	NA	NA	NA	NA
WP_094104532.1\|973088_974966_-	hypothetical protein	E9LUR1	Lactobacillus_phage	1.5e-79	39.2
WP_094104533.1\|974969_975251_-	hypothetical protein	A8ASK5	Listeria_phage	1.2e-06	39.4
WP_094104534.1\|975226_975601_-	hypothetical protein	NA	NA	NA	NA
WP_094104535.1\|975607_976045_-	hypothetical protein	NA	NA	NA	NA
WP_094104536.1\|976117_976657_-\|capsid	capsid protein	O03972	Lactobacillus_phage	5.1e-41	52.6
WP_094104537.1\|976660_977056_-	hypothetical protein	Q5YA65	Bacillus_phage	3.0e-22	40.5
WP_094104538.1\|977077_977392_-	hypothetical protein	U3PIU9	Lactobacillus_phage	8.6e-17	57.1
WP_094104539.1\|977391_977739_-\|capsid	capsid protein	O03932	Lactobacillus_phage	9.2e-20	45.3
WP_094104540.1\|977735_978152_-	hypothetical protein	NA	NA	NA	NA
WP_094104541.1\|978219_979128_-	hypothetical protein	Q6SED2	Lactobacillus_prophage	4.8e-108	64.3
WP_094104542.1\|979140_979698_-	hypothetical protein	A8ASJ5	Listeria_phage	8.7e-20	42.1
WP_094104543.1\|979796_980930_-	hypothetical protein	O03929	Lactobacillus_phage	1.7e-70	43.0
WP_094104544.1\|980926_982474_-\|portal	phage portal protein	O03928	Lactobacillus_phage	6.5e-158	57.0
WP_094104545.1\|983846_984347_-\|terminase	terminase small subunit	O03926	Lactobacillus_phage	5.9e-52	65.1
WP_094104546.1\|984346_984556_-	hypothetical protein	NA	NA	NA	NA
WP_151201392.1\|984897_985284_-	hypothetical protein	NA	NA	NA	NA
WP_094104548.1\|985930_986374_-	hypothetical protein	NA	NA	NA	NA
WP_094104549.1\|986563_986782_-	hypothetical protein	NA	NA	NA	NA
WP_094104550.1\|986744_986987_-	hypothetical protein	NA	NA	NA	NA
WP_094104551.1\|987238_987610_-	hypothetical protein	O03921	Lactobacillus_phage	1.2e-28	57.3
WP_094104552.1\|987602_988142_-	DUF1642 domain-containing protein	A0A141E054	Streptococcus_phage	8.2e-15	40.2
WP_094104553.1\|988141_988504_-	hypothetical protein	NA	NA	NA	NA
WP_151201393.1\|988669_989089_-	DeoR family transcriptional regulator	NA	NA	NA	NA
WP_094104555.1\|988997_989522_-	single-stranded DNA-binding protein	A0A2H4J1H8	uncultured_Caudovirales_phage	7.9e-39	65.6
WP_094104556.1\|989539_989800_-	hypothetical protein	NA	NA	NA	NA
WP_094104557.1\|989768_990470_-	hypothetical protein	E9LUU3	Lactobacillus_phage	2.0e-82	64.8
WP_094104558.1\|990473_991304_-	helix-turn-helix domain-containing protein	U5U793	Lactobacillus_phage	9.9e-36	34.3
WP_094104866.1\|991314_992085_-	hypothetical protein	A0A0P0IZH9	Lactobacillus_phage	1.9e-57	45.3
WP_094104559.1\|992119_992884_-	phage recombination protein Bet	A8ATK8	Listeria_phage	2.1e-56	51.5
WP_094104560.1\|992876_993158_-	hypothetical protein	NA	NA	NA	NA
WP_094104561.1\|993395_993671_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_094104867.1\|993671_993995_-	hypothetical protein	NA	NA	NA	NA
WP_094104562.1\|994203_994446_-	hypothetical protein	NA	NA	NA	NA
WP_094104868.1\|994863_995181_+	helix-turn-helix transcriptional regulator	A8ATX5	Listeria_phage	2.2e-12	50.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP021475

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021475_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021475_1

54075-54151

Orphan

Consensus_repeat	Method
TTTTTCTGTTGCCAGCCAACTATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021475_1

>merge|NZ_CP021475|1|54075-54151|CRISPRCasFinder
TTTTTCTGTTGCCAGCCAACTATCTAGGACAAGCCTAGCTTAATATATCTGATTTTTCTGTTGTCAGCCAACTATCT

>NZ_CP021475|1|1|54075-54151|CRISPRCasFinder
TTTTTCTGTTGCCAGCCAACTATCT	AGGACAAGCCTAGCTTAATATATCTGA
TTTTTCTGTTGTCAGCCAACTATCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021475.1\|WP_061812763.1\|62432_62747_-\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP021475.1\|WP_094104913.1\|64512_64797_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP021475.1\|WP_094104893.1\|48731_50795_+\|MobA/MobL-family-protein	unknown	unknown	gnl\|CDD\|367473
NZ_CP021475.1\|WP_094104911.1\|62901_63552_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP021475.1\|WP_061812772.1\|52597_53164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021475.1\|WP_094104890.1\|46838_47036_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021475.1\|WP_008212308.1\|50878_51190_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021475.1\|WP_094104892.1\|47954_48233_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021475.1\|WP_061812766.1\|56055_57210_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NZ_CP021475.1\|WP_094104909.1\|57332_58901_+\|ClC-family-H(+)/Cl(-)-exchange-transporter	unknown	unknown	gnl\|CDD\|238504
NZ_CP021475.1\|WP_094104894.1\|51841_52177_+\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|374896
NZ_CP021475.1\|WP_094104907.1\|53348_54020_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376232
NZ_CP021475.1\|WP_061812767.1\|55208_55502_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180760
NZ_CP021475.1\|WP_094104908.1\|54384_55092_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090
NZ_CP021475.1\|WP_094104906.1\|52197_52560_+\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|274860
NZ_CP021475.1\|WP_151201402.1\|41786_42035_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021475.1\|WP_107696660.1\|59237_59327_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021475.1\|WP_094104912.1\|63567_64491_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP021475.1\|WP_094104891.1\|47086_47833_+\|filamentation-induced-by-cAMP-protein-fic	unknown	unknown	gnl\|CDD\|225718
NZ_CP021475.1\|WP_094104910.1\|61073_62411_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224169

Protein	Function_ID	Function_description	E-value
NZ_CP021475.1\|WP_061812763.1\|62432_62747_-\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	5.3615e-37
NZ_CP021475.1\|WP_094104893.1\|48731_50795_+\|MobA/MobL-family-protein	gnl\|CDD\|367473	pfam03389, MobA_MobL, MobA/MobL family. This family includes of the MobA protein from the E. coli plasmid RSF1010, and the MobL protein from the Thiobacillus ferrooxidans plasmid PTF1. These sequences are mobilisation proteins, which are essential for specific plasmid transfer.	5.02286e-101
NZ_CP021475.1\|WP_094104911.1\|62901_63552_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	6.52461e-78
NZ_CP021475.1\|WP_094104907.1\|53348_54020_-\|hypothetical-protein	gnl\|CDD\|376232	pfam18813, PBECR4, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine residue.	1.30693e-14
NZ_CP021475.1\|WP_094104913.1\|64512_64797_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.25391e-13
NZ_CP021475.1\|WP_061812766.1\|56055_57210_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	6.82291e-59
NZ_CP021475.1\|WP_094104909.1\|57332_58901_+\|ClC-family-H(+)/Cl(-)-exchange-transporter	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	1.23291e-167
NZ_CP021475.1\|WP_094104894.1\|51841_52177_+\|conjugal-transfer-protein	gnl\|CDD\|374896	pfam16943, T4SS_CagC, Cag pathogenicity island, type IV secretory system. T4SS_CagC is a family of putative pathogenicity island, type IV, conjugal DNA-protein transfer, secretory system proteins from Gram-negative bacteria.	5.8983e-41
NZ_CP021475.1\|WP_061812767.1\|55208_55502_+\|hypothetical-protein	gnl\|CDD\|180760	PRK06934, PRK06934, flavodoxin; Provisional.	5.03954e-16
NZ_CP021475.1\|WP_094104908.1\|54384_55092_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	1.89377e-77
NZ_CP021475.1\|WP_094104906.1\|52197_52560_+\|conjugal-transfer-protein	gnl\|CDD\|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	0.00461756
NZ_CP021475.1\|WP_094104912.1\|63567_64491_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	1.55236e-130
NZ_CP021475.1\|WP_094104891.1\|47086_47833_+\|filamentation-induced-by-cAMP-protein-fic	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	0.00810462
NZ_CP021475.1\|WP_094104910.1\|61073_62411_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224169	COG1249, Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion].	1.02713e-93

>NZ_CP021475.1|WP_094104907.1|53348_54020_-|hypothetical-protein
MNQKLLDNDPDYHKITSSELISFKTYLPKIQNSFSIIKKHFIGKIKTYIYAVNNREIRSLPVTIQNRHFMHLCGVKYTKGASGFVKDLKNNRLNLNELYLKEDGSTFQKLEVIDKINLLDTLETTVSIGNNMARIHYDNLLRTKANILGIVVDTDDNGINFPLSLLNISATDLHTLKRFKVFAILEENKSTHVKRCLPKNKSCTKKLNEYIDQLLNVPKKGDC
>NZ_CP021475.1|WP_061812772.1|52597_53164_+|hypothetical-protein
MIGGDEPDNALKLKTLYHEYAHSQLHGLKSAFKDRPRAYQETQAEAVAYVAMQNIGVDTSNYSLGYVATWAKDKAVIHSALSEIQQVSNKVIELSDGLTKQLGLQEAQKEPEHDLKKLSPQALNQSYQDLQQQIRQATNPQKKSELKNQLNDVHQEISDRAQKNLQAFAEQNPGIKQPESELDQSLKR
>NZ_CP021475.1|WP_094104906.1|52197_52560_+|conjugal-transfer-protein
MKKGKEFIFPENVDKDYGIWKDYTLKDFGYAALAGLVGLIFIEIPPYGLILVLIKIVIVVLAMTIVMAILTIRPVAARKNIKVRDNFKLKRRYANGQKLFYLKPKKRGELNAFEEEQNRQ
>NZ_CP021475.1|WP_094104894.1|51841_52177_+|conjugal-transfer-protein
MKFSKVKALATTGATTIYLGLMNAQVVFAADGSKVKSKLTQAGKTIQGILTGLVVLVGICVALFIIIKRMPNADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSLFT
>NZ_CP021475.1|WP_008212308.1|50878_51190_+|hypothetical-protein
MTKKQEWFSLAQASLKLERGSTYVSVWLRRHPNELPSEMLMETGKVKLISEDGIEWIKNHIKKEGVLVSSEVANGDQHLEVTILGVTLLTIHFTGRVRGKLVV
>NZ_CP021475.1|WP_094104893.1|48731_50795_+|MobA/MobL-family-protein
MAIFHMSFSNISAGKGRSAIASAAYRSGEKLFDDKEGRHYFYARSIMPESFILTPKNSPEWASDREQLWNEVEKKDRKSNSRYAKEFNVALPVELSESEQKELLTKYVQENFVDEGMVADVAIHRDHPDNPHAHVMLTNRPFNSDGTWGIKSKKQYILDDNGNKTYTGTSKYPKSRKILMVDWDKKEKITEWRHNWAASVNEILEQKNIPDRISEKSFIEQGIADTPMQHEGINSKRHERKAFNQQVKNYRKSKAGYKNMQEKVVNRGHLDSLSKHFSFNEKKVVKELSHELKTYISLESLDDKRRMLFNWKNSTLIKHAVGQDVTKQLLTINQQESSLKKADELLNKVVDRTTKKLYPELNFEQTTQAERRELIKETDSEQTVFKGSELNERLMNIRDDLLTQQLLTFTKRPYVGWKLLMQQEKEVKIELKYTLMIHDDNLESLEHVDQGLLEKYSPTEQQKITRAVKDLRTIMAVKQVIQTQYQEVLRRAFPNGNFNELPMIKQEQAYTAVMYYDPVLKPCQAETIEQWQANPPQVFSPQEHQQGLAYLSGQLSLDQLENHYLQRVLKHDGTKQLFFGECKADPTIKNSQIEKIQKQLKGQQAKDDQYRKANIGHYQPLNYKPVSPDYYLKTAFSDAIMTVLYARDEDYQRQRQAQGLKETEWEMTKKQRQHQARNRHEDGSMHL
>NZ_CP021475.1|WP_094104892.1|47954_48233_-|hypothetical-protein
MPNQYEKLVEQQARLKQKIDREDFKLRQSKYYENRQARKARSRRLIQKGALLEKHFQADNLSVEQTEELLKIFTDYVNAHKPDKLKNDQPNN
>NZ_CP021475.1|WP_094104891.1|47086_47833_+|filamentation-induced-by-cAMP-protein-fic
MAKTRTYMDKYKFTAAENQRFARANFTKLVHTNARFEGVNTTLPQTQTIMDGMSVAGVPVEDVLTIVNLKRGWQYITAQNPPLTLIMKKQINKLVAAEDALVPGELRQGKGGVDLGSEDFLEPPLINEKQEQSFLQKILADPRTTITDKALTVMYHNMRQQIFWDGNKRTATLSANKIMIDGGAGLINIPLDKWDQWNELIANYYQTNDMTKIKQWTYDNGIQGLQIRANKKLSANELNQMHKQLKNG
>NZ_CP021475.1|WP_094104890.1|46838_47036_+|hypothetical-protein
MTKPSKEIETFDQLLADPWAVDIQGVWEQAARNPDPDKRKLFDALHIYLLDKRQEQIINEKHFVI
>NZ_CP021475.1|WP_151201402.1|41786_42035_-|hypothetical-protein
MSSTAGETFFDLTTLYLGSSISIGLPAFFLLTGLELLTLSKFAFLFSNTLAPVPLEKALLSKLNSPLISTFSFLFLYHLKAY
>NZ_CP021475.1|WP_094104908.1|54384_55092_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MMILCNPHNPIGRVWNRSELAKIAKLCQKYHVLLVSDEIHGDLVFKRTVYTPIFDLPDSLIDNTVALISPSKNFNIAVLHAATVVAPNDNVRARINRGINNDELAEPNLLSIPATVAAYRNSDEWLDKLKGYLATNREYVAFYLQAHLPEVKFASENATYLLWLDVSAYTDSAEKLAAFIRVDIGLYLSAGTVYRGNGAYFIRMNVACPLTTVEEGLRRLTQSLNHWQLQGGNAS
>NZ_CP021475.1|WP_061812767.1|55208_55502_+|hypothetical-protein
MAEIRPIIDYPDEYQQVLKITKHELDERTFPKIMPITADIAGSNHIILAFPNWWNHLPRPIVTFMEQYQWQDKTIYPVCTHEGNRFGDSLNELSEIA
>NZ_CP021475.1|WP_061812766.1|56055_57210_+|cation:proton-antiporter
MEFLGTLVIILIATSLFGHLASRVGIPAVIGQLFVGIILGPALLNWVHANDFIHIFSEIGVIILMFIAGLESDLALLKKYLRPSIIVALLGVLIPMVLIYPVGIVFGLTQFESLFLSVIFAATSVSISVAVMKELNLLDSKSGSTVLGAAVVDDVLAVVLLSIMVSLIGTKAGTDTQIPLALTFLEQLIYFAAIYFVMRFIAPLLARLGTKLLNPVGPTIMAMILCFGMAYIANLIGLSAVIGAFFAGIAIAQTHVAHEVDQSIEPIGYAIFIPVFFVSIGLSMSLAGIEHDLLLIIVLTIVATLTKLLGAGSGAKWAGFSSNEAYLVGAGMVSRGEMALIIAQIGYQSKLISDDYYSAIITAIILTTLLAPLLLKHAARHINY
>NZ_CP021475.1|WP_094104909.1|57332_58901_+|ClC-family-H(+)/Cl(-)-exchange-transporter
MIQLVKEKFDVTRLRFVLLGLLVGLMSGTVVSLFRYCIDIGLHYSRLVYRYLRIAPFVWWEWALLIGINLGLALIVARLLKREPYIAGSGIPQVEGQLAGELEMHWWSILWRKFIGGILALGPGLFLGREGPSIQLGASVGQGFASGFKLSGTDRRLLIASGAAAGLAAAFNAPIAGTLFVLEEIYHNFSPLVWLTALAGAIGSNFISLNVFGLVPVLHLSYSRSLPVSNYWHLILLGIVLGLFGYLYQRVLLVMPRWYHQLTHLPRPIQGIVPFLLVILVGYFSPNLLGGGNGLIVGFGQYVPPLFVLIAIFIIRFVFSMISYGSGLPGGIFLPILSLGAVIGAVYGVLMNQLGLLSHVYIMNLIIFSMAGYFAGIGKAPFTAILLVTEMVGNLTHLMPLAVISLTAYLVVDLLGGAPIYEALLKQMTMPKTVQQLHRPDHLEIPVFFGSPLNGKMVRDMPWPKEALLIGIRRGEQEVIPHGDTLIHEGDTLVLLTDTTQRPQVKQRIDALLATLEKKHQD
>NZ_CP021475.1|WP_107696660.1|59237_59327_-|hypothetical-protein
MSVFQALSLMLLFGTFLIALLSYIDKHHK
>NZ_CP021475.1|WP_094104910.1|61073_62411_-|NAD(P)/FAD-dependent-oxidoreductase
MEKFNYVVVGSGPSVYRFLLGMKDSKKKILVVEKKCFGGICPNEGCEPKIFLEGAVRAVLTSRKLEGKGIETPGKLNWQRLIQYKKEVFAPFPKSTQQMYEGLGAQTLTGTASFIDSHHISVESGVIEADNFVIATGRTPRQLSFPGQEYTLTSTDIFDLEDLPKRIAIIGSGYVGMEITTLLAAAGSDVTIIQHSDRPLRSFYSQHVQQLVNEMKDSLGIEFKFNTSVKAITKKESGYQLETTTGDKSNFDTVVNASGRVPNLGSLNLSAAGVEATEDGIKTNGFLQSSSENIYALGDVLSKKVPGLTPTAQFEGDYLSALFTEKETKPIQYPVIGTVAFTFPQVAQAGINIDEARNNEKYVIKDIDITAGDFFYQGTADNARLTIVYDKKTGRLKGASEISQTAVDDINNLIPVMSLDVQPDDWKKKMLMAFPGLAYKIRNLV
>NZ_CP021475.1|WP_061812763.1|62432_62747_-|thioredoxin
MIKNVTDQDFKKETNTGVTLTDFWATWCPPCRMQGPIIEELDKDMGDKVKISKMDVDANQNTPAEFGIMSIPTLIIKKDGKIMEKLVGLHSKDQLKQVLSQHTD
>NZ_CP021475.1|WP_094104911.1|62901_63552_-|DsbA-family-oxidoreductase
MEIKYWSDIACPFCYIGSNRMKKAMKEIGIYDETELKFKSFELNPATPKVTTEGYINHFTQGNKSLESQSKKQMAYIESMAHADGLSMEINKVVPTNTMDAHRLIKLAGSKGDPALTERVIKRFYQVYFSDGTSIADHDVLVNAATDAGLAKDEIEAVLDSDKYHDDVISDEVEAQQSGIHAAPFFVINNKYAISGAQPYEVFVKALKQVQAEEEA
>NZ_CP021475.1|WP_094104912.1|63567_64491_-|thioredoxin-disulfide-reductase
METYDVLVIGAGPGGMTAALYAARANLKVGMIDRGIYGGQMNNTDDIENYPGFTSIKGPDLSEKMYQSTVKAGVNFICGDVQEVTVDSNQWKHIKTDSEELAAKSVIIATGSTNKKLGVPGEEEFSGKGVSYCAVCDGAFFKGKQVTAIGGGDSAISEGLYLANVTNKVNVVHHRDTLRAQQVLQDRAFENPKMNFTWNTTVEKIIGDENHVTGIEVVDTKTNEKKVINTDGIFIYIGNLPNSQLFKRLNITDSAGWILTNDDMETNIPGVFAIGDVRKKRLRQITTAVGDGGIAGQNAYEYVENFN
>NZ_CP021475.1|WP_094104913.1|64512_64797_-|thioredoxin-family-protein
MVKLDIPKLKMLVFENDWCAQCYTERPIIRRLAIKYHDQLEVEVLNADNNPLMVKKYNVLTAPSIILIKNDEMVERISRFIDQNQLETVIRYYL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021475_1	1.1\|54100\|27\|NZ_CP021475\|CRISPRCasFinder	54100-54126	27	NZ_CP021475	Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-4, complete sequence	54100-54126	0	1.0

1. spacer 1.1|54100|27|NZ_CP021475|CRISPRCasFinder matches to NZ_CP021475 (Pediococcus pentosaceus strain SRCM100892 plasmid pPC892-4, complete sequence) position: , mismatch: 0, identity: 1.0

aggacaagcctagcttaatatatctga	CRISPR spacer
aggacaagcctagcttaatatatctga	Protospacer
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Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021471

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP021474

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP021475

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection