CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021868	Streptococcus agalactiae strain SG-M8 chromosome, complete genome	3 crisprs	cas3,RT,DinG,csa3,cas9,cas1,cas2,csn2,csm6,DEDDh	3	14	5	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021868_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021868_1

976520-977347

TypeII

II-A

Consensus_repeat	Method
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRT

12 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP021868_1

>merge|NZ_CP021868|1|976520-977347|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAAGTCCAGTAGGAGAATCTGAATTATCATTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTGAAAAATTACTTTATGTTGATACTCCTTTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGATATGGTGGACAGGTTCAGCAGGTCATGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTCTGCGGGACGGATAACGTTCAAATTAGGCGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGATGAGTCTGATTGAAGCGTTGGAAGTTTTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGGAACGAACGGTTAAGCCTTTCAACGCTTCGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACCACTGACCACCTCTGAACAACCATTCATCAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAATTCTGCTTTGAAATCAAGTTCCATTTCTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTGCTCCAAACGGGCATTTTCAGCTTTTAGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTGAATAAATAAGCTACAAAAGATAGGATTGGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAAAAAATTAATGACGCAATTGCTAAGTCAAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACACAGACTTTAGATTTTTATGAAAAAAATGTGTTTTAGAGCTGTGCTGTTATTATGCTAGGACATCA

>NZ_CP021868|1|1|976520-977281|PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAGTCCAGTAGGAGAATCTGAATTATCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGAAAAATTACTTTATGTTGATACTCCTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GATATGGTGGACAGGTTCAGCAGGTCATGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCTGCGGGACGGATAACGTTCAAATTAGGC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GATGAGTCTGATTGAAGCGTTGGAAGTTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAACGAACGGTTAAGCCTTTCAACGCTTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CACTGACCACCTCTGAACAACCATTCATCA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AATTCTGCTTTGAAATCAAGTTCCATTTCT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGCTCCAAACGGGCATTTTCAGCTTTTAGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGAATAAATAAGCTACAAAAGATAGGATTG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAAAAATTAATGACGCAATTGCTAAGTCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_CP021868|1|1|976520-977281|CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAGTCCAGTAGGAGAATCTGAATTATCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGAAAAATTACTTTATGTTGATACTCCTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GATATGGTGGACAGGTTCAGCAGGTCATGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCTGCGGGACGGATAACGTTCAAATTAGGC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GATGAGTCTGATTGAAGCGTTGGAAGTTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAACGAACGGTTAAGCCTTTCAACGCTTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CACTGACCACCTCTGAACAACCATTCATCA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AATTCTGCTTTGAAATCAAGTTCCATTTCT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGCTCCAAACGGGCATTTTCAGCTTTTAGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGAATAAATAAGCTACAAAAGATAGGATTG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAAAAATTAATGACGCAATTGCTAAGTCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_CP021868|1|1|976520-977347|CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAGTCCAGTAGGAGAATCTGAATTATCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGAAAAATTACTTTATGTTGATACTCCTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GATATGGTGGACAGGTTCAGCAGGTCATGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCTGCGGGACGGATAACGTTCAAATTAGGC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GATGAGTCTGATTGAAGCGTTGGAAGTTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAACGAACGGTTAAGCCTTTCAACGCTTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CACTGACCACCTCTGAACAACCATTCATCA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AATTCTGCTTTGAAATCAAGTTCCATTTCT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGCTCCAAACGGGCATTTTCAGCTTTTAGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGAATAAATAAGCTACAAAAGATAGGATTG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAAAAATTAATGACGCAATTGCTAAGTCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ACAGACTTTAGATTTTTATGAAAAAAATGT
GTTTTAGAGCTGTGCTGTTATTATGCTAGGACATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021868.1\|WP_000122194.1\|975425_975767_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP021868.1\|WP_088181599.1\|970445_974558_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NZ_CP021868.1\|WP_000159234.1\|965902_966274_+\|YbgA-family-protein	unknown	unknown	gnl\|CDD\|377982
NZ_CP021868.1\|WP_001241816.1\|966298_966679_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131381
NZ_CP021868.1\|WP_001019133.1\|978456_980289_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP021868.1\|WP_000653357.1\|969402_970059_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NZ_CP021868.1\|WP_000665410.1\|984300_984735_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_CP021868.1\|WP_000523795.1\|967904_968642_+\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NZ_CP021868.1\|WP_000192686.1\|991693_992392_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP021868.1\|WP_001056394.1\|990251_990863_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_CP021868.1\|WP_000914664.1\|966770_967901_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_CP021868.1\|WP_000065321.1\|987678_988782_+\|DUF2974-domain-containing-protein	unknown	unknown	gnl\|CDD\|371412
NZ_CP021868.1\|WP_000168905.1\|984886_987679_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|223550
NZ_CP021868.1\|WP_000146565.1\|988902_989541_-\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NZ_CP021868.1\|WP_000180007.1\|983168_983828_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_CP021868.1\|WP_000467138.1\|990899_991682_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021868.1\|WP_000323544.1\|968642_969413_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP021868.1\|WP_000929489.1\|974559_975429_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP021868.1\|WP_000438314.1\|977904_978321_+\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_CP021868.1\|WP_000590706.1\|975753_976419_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	pfam09711_csn2_CAS-II-A	gnl\|CDD\|213408

Protein	Function_ID	Function_description	E-value
NZ_CP021868.1\|WP_000122194.1\|975425_975767_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.38084e-52
NZ_CP021868.1\|WP_088181599.1\|970445_974558_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0
NZ_CP021868.1\|WP_000159234.1\|965902_966274_+\|YbgA-family-protein	gnl\|CDD\|377982	pfam08349, DUF1722, Protein of unknown function (DUF1722). This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.	6.08694e-28
NZ_CP021868.1\|WP_001241816.1\|966298_966679_+\|hypothetical-protein	gnl\|CDD\|131381	TIGR02328, TIGR02328, conserved hypothetical protein. Members of this protein are found in a small number of taxonomically well separated species, yet are strongly conserved, suggesting lateral gene transfer. Members are found in Treponema denticola, Clostridium acetobutylicum, and several of the Firmicutes. The function of this protein is unknown. [Hypothetical proteins, Conserved].	6.45558e-80
NZ_CP021868.1\|WP_001019133.1\|978456_980289_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP021868.1\|WP_000653357.1\|969402_970059_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	9.75792e-52
NZ_CP021868.1\|WP_000665410.1\|984300_984735_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	6.40832e-86
NZ_CP021868.1\|WP_000523795.1\|967904_968642_+\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	3.68196e-111
NZ_CP021868.1\|WP_000192686.1\|991693_992392_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.55032e-60
NZ_CP021868.1\|WP_001056394.1\|990251_990863_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	6.1265e-31
NZ_CP021868.1\|WP_000914664.1\|966770_967901_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_CP021868.1\|WP_000065321.1\|987678_988782_+\|DUF2974-domain-containing-protein	gnl\|CDD\|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	1.82724e-105
NZ_CP021868.1\|WP_000168905.1\|984886_987679_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP021868.1\|WP_000146565.1\|988902_989541_-\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	6.8383e-72
NZ_CP021868.1\|WP_000180007.1\|983168_983828_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.66997e-33
NZ_CP021868.1\|WP_000323544.1\|968642_969413_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.19143e-132
NZ_CP021868.1\|WP_000929489.1\|974559_975429_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.54315e-139
NZ_CP021868.1\|WP_000438314.1\|977904_978321_+\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	4.64422e-78
NZ_CP021868.1\|WP_000590706.1\|975753_976419_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.61399e-122

>NZ_CP021868.1|WP_000590706.1|975753_976419_+|type-II-A-CRISPR-associated-protein-Csn2
MIKINFPILDEPLVLSNATILTIEDVSVYSSLVKHFYQYDVDEHLKLFDDKQKSLKATELMLVTDILGYDVNSAPILKLIHGDLENQFNEKPEVKSMVEKLAATITELIAFECLENELDLEYDEITILELIKALGVKIETQSDTIFEKCFEIIQVYHYLTKKNLLVFVNSGAYLTKDEVIKLCEYINLMQKSVLFLEPRRLYDLPQYVIDKDYFLIGENMV
>NZ_CP021868.1|WP_000122194.1|975425_975767_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTETAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNTANNAMIGRLKVNNPKKGNITLLTVTEKQFARMVYLHGERNTSVANSDSRLVFLGDSYDQD
>NZ_CP021868.1|WP_000929489.1|974559_975429_+|type-II-CRISPR-associated-endonuclease-Cas1
MAGWRTVVVNTHSKLSYKNNHLIFKDSYQTEMIHLSEIDILIMETTDIVLSTMLIKRLVDENILVIFCDDKRLPTAMLMPYYARHDSSLQLSRQMSWIEDVKADVWTSIIAQKILNQSFYLGECSFFEKSQSIMNLYHDLEPFDPSNREGHAARIYFNTLFGNDFSREQDNPINAGLDYGYSLLLSMFAREVVKCGCMTQFGLKHANQFNQFNLASDIMEPFRPIVDRIIYENRQSDFVKMKRELFSMFSETYSYNGKEMYLSNIVSDYTKKVIKSLNSDGNGIPEFRI
>NZ_CP021868.1|WP_088181599.1|970445_974558_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MNKPYSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTASDRRLKRTARRRYTRRRNRILYLQEIFAEEMSKVDDSFFHRLEDSFLVEEDKRGSKYPIFATLQEEKDYHEKFSTIYHLRKELADKKEKADLRLIYIALAHIIKFRGHFLIEDDSFDVRNTDISKQYQDFLEIFNTTFENNDLLSQNVDVEAILTDKISKSAKKDRILAQYPNQKSTGIFAEFLKLIVGNQADFKKYFNLEDKTPLQFAKDSYDEDLENLLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKASLPEKYQEIFADSSKDGYAGYIEGKTNQEAFYKYLSKLLTKQEDSENFLEKIKNEDFLRKQRTFDNGSIPHQVHLTELKAIIRRQSEYYPFLKENQDRIEKILTFRIPYYIGPLAREKSDFAWMTRKTDDSIRPWNFEDLVDKEKSAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKNEQGETYFFDSNIKQEIFDGVFKEHRKVSKKKLLDFLAKEYEEFRIVDVIGLDKENKAFNASLGTYHDLEKILDKDFLDNPDNESILEDIVQTLTLFEDREMIKKRLENYKDLFTESQLKKLYRRHYTGWGRLSAKLINGIRDKESQKTILDYLIDDGRSNRNFMQLINDDGLSFKSIISKAQAGSHSDNLKEVVGELAGSPAIKKGILQSLKIVDELVKVMGYEPEQIVVEMARENQTTNQGRRNSRQRYKLLDDGVKNLASDLNGNILKEYPTDNQALQNERLFLYYLQNGRDMYTGEALDIDNLSQYDIDHIIPQAFIKDDSIDNRVLVSSAKNRGKSDDVPSLEIVKDCKVFWKKLLDAKLMSQRKYDNLTKAERGGLTSDDKARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIRKVKIVTLKSNLVSNFRKEFGFYKIREVNNYHHAHDAYLNAVVAKAILTKYPQLEPEFVYGDYPKYNSYKTRKSATEKLFFYSNIMNFFKTKVTLADGTVVVKDDIEVNNDTGEIVWDKKKHFATVRKVLSYPQNNIVKKTEIQTGGFSKESILAHGNSDKLIPRKTKDIYLDPKKYGGFDSPIVAYSVLVVADIKKGKAQKLKTVTELLGITIMERSRFEKNPSAFLESKGYLNIRADKLIILPKYSLFELENGRRRLLASAGELQKGNELALPTQFMKFLYLASRYNESKGKPEEIEKKQEFVNQHVSYFDDILQLINDFSKRVILADANLEKINKLYQDNKENISVDELANNIINLFTFTSLGAPAAFKFFDKIVDRKRYTSTKEVLNSTLIHQSITGLYETRIDLGKLGED
>NZ_CP021868.1|WP_000653357.1|969402_970059_+|TIGR01906-family-membrane-protein
MKDKLLVVLTWIWIISLATLATIYIAWLIYPIEIQFLKLEKVVYLKAETIYYNFNKLMIYLTHPFISDLNMPSFPSSEDGLKHFADVKYLFTLAHGLFVILTFPVIYFLRRGWKQKSIFLYEGFFKIAIMLPIFIVVCAFLLGFDQFFTLFHEVLFPGDSTWQFNPLTDPVIWILPETFFLHCFIIFLLIYETITIILLIIGRKHLKLRKYKNKMQAL
>NZ_CP021868.1|WP_000323544.1|968642_969413_+|TIGR01457-family-HAD-type-hydrolase
MAYKGYLIDLDGTIYKGKSRIPAGERFIERLQEKGIPYMLVTNNTTRTPESVQEMLRGFNVETPLETIYTATMATVDYMNDMNRGKTAYVIGEEGLKKAIADAGYVEDTKNPAYVVVGLDWNVTYDKLATATLAIQNGALFIGTNPDLNIPTERGLLPGAGSLNALLEAATRIKPVFIGKPNAIIMNKALEILNIPRNQAVMVGDNYLTDIMAGINNDIDTLLVTTGFTTVEEVPDLPIQPSYVLASLDEWTFNEG
>NZ_CP021868.1|WP_000523795.1|967904_968642_+|acyl-ACP-thioesterase
MGLLYRETYEVPFYESDTNHYMKLPQLLALALQISAKQSLKLGIGDDIVFKRYGLVWVVTDYIIDIERLPKHAEKIVIETEAKAHNKLLCYRYFYIYGEDGQKIITISSAFVLMDFKTRKIHPVLDDITSIYQSQRIKKVIRGPKYHPIGDSKVKQYHVRYFDLDMNGHVNNSKYLEWMYDVLDLDFLSSHIPKKIDLKYIKEIQYGTDIKSHWYQDGLVTRHDIIGGDAIHAQARIEWQEKKED
>NZ_CP021868.1|WP_000914664.1|966770_967901_+|oxygen-independent-coproporphyrinogen-III-oxidase
MLKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDAYLQALIREFRSYDITELRTLYIGGGTPTSISAVQLDYLLTELSRDLNLNTLEEFTIEANPGDLTVDKIEVLQKSAVNRVSLGVQTFNDKHLKRIGRSHNEAQIYSTIDALKTAGFQNISIDLIYALPGQTMDDVRSNVAKALSLNIPHLSLYSLILEHHTVFMNKMRRGKLHLPTEDLEAEMFEYIISEMERNGFEHYEISNFTKPGFESRHNLMYWDNVEYYGVGAGASGYLDGIRYRNRGPIQHYLKGVSEGNARLSEEVLSKNEMMEEELFLGLRKKEGVSIGKFEQKFGTSFEKRYGQIVQELQSDGLLKENNGFIQMTKKGLFLGDTVAEKFIVE
>NZ_CP021868.1|WP_001241816.1|966298_966679_+|hypothetical-protein
MRLWHQDIIELLPRQQLLGQHRECCALRGNGWGRKHETVDYVFRYSPYRLFAYHQLVMEEMMERGYRVSKEWLIAEYRGMKCPRYDTLNPVDLETPIYPEHNQDYLQECLWNLKAKGIDLPINKIK
>NZ_CP021868.1|WP_000159234.1|965902_966274_+|YbgA-family-protein
MTKEAELLWAKHKYLVLSKSQKIYLDIRQTLKSPNCTVLDVQSLIDQAVLLEESPSQVTNAYMHIWGYFKNKAERQEKEEFLTLLEKYRKTGYQRRKLLAFLKQLLAKYPNSYLQNSSIFEEE
>NZ_CP021868.1|WP_000438314.1|977904_978321_+|nucleoside-diphosphate-kinase
MEQTFFMIKPDGVKRGFIGEVISRIERRGFSIDRLEVRYADADILKRHYAELTDRPFFPTLVDYMTSGPVIIGVISGEEVISTWRTMMGSTNPKDALPGTIRGDFAQAPSPNQATCNIVHGSDSPESATREIAIWFNN
>NZ_CP021868.1|WP_001019133.1|978456_980289_+|elongation-factor-4
MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
>NZ_CP021868.1|WP_000180007.1|983168_983828_+|HD-domain-containing-protein
MTMVKREDVILNATENMVHHKLKNDPSGHDWFHIVRVRNLAVELAHKEGANTFICQMAALLHDIIDDKICQDSKQASYELTQWLYSQDLAIAEVEHILDILENISFKAGTGLTMKTLEGQIVQDADRLDAMGAIGIARTMAYSGSKGRLIHDPNLKPRENLTLEEYRNGQDTAIMHFYEKLLKLKDLMNTKQGKMLAQKRHDFLELYLAEFYAEWNGKR
>NZ_CP021868.1|WP_000665410.1|984300_984735_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MKETQEELRQRIGHTAYQVTQNSATEHAFTGKYDDFFEEGIYVDIVSGEVLFSSLDKFQSGCGWPAFSKPIENRMVTNHQDHSHGMHRIEVRSRQADSHLGHVFNDGPVDAGGLRYCINSAALDFIPYDQMAKRGYGDYLSLFD
>NZ_CP021868.1|WP_000168905.1|984886_987679_+|cation-transporting-P-type-ATPase
MASTNNVSDTNTRFAKEELEEVFEELGTTQGGLSDEEVAVRQKKYGLNLLSEVKQESIILLFLKNFTSLMAILLWVGGFVAIVSNSLELGLAIWMVNVINGIFSFIQEYRASQATQALEKMLPSYSRVLRKSSEEKILSEQLVPGDIVLIEEGDRISADGRLIKTTDLQVNQSALTGESNPIYKDSNVENDQSKTLIECDNMVFAGTTVSSGSATMVVTAIGMQTQFGQIADLTQGMKSEKSPLQRELDRLTKQISIISITVGIIFFLAATFFVKEPVSKSFIFALGMIVAFIPEGLLPTVTLSLAMAVQRMAKEHALVKKLSSVETLGATSVICSDKTGTLTQNEMTVNHLWQNGKSYQVTGLGYAPEGQILFEGDNICFGNSDRGDLEKLIRFAHLCSNAQVLPPNDDRSTYTVLGDPTEACLNVLLEKSGINIQENRKFAPRLKELPFDSVRKRMTTIHSLGGDEKDKKISITKGAPKEILDLSDYVLSDGKVIPLNKEERNKIQLANDTFAKDGLRVLAVSYCDIEGFSKEQWTQENLEQHMVFIGLIAMSDPPREGVREAIDKCHAASIRIIMVTGDYGLTALSIAKNIGIIRNDDAKVISGLELSEMTDSQLKKELSGEVVFARVAPEQKYRVVTILQEMGEVVAVTGDGVNDAPALKKSDIGVAMGVTGTDVAKESADMILTDDHFASIVHAVEEGRAVYQNIKKFLTYIFNSNTPEAVPSAFFLFSKGFIPLPLTVMQILAVDLGTDMLPALGLGVEPPETDVMNRPPRRLTDRLLDKGLLIKSFLWYGTIESVLAMGGFFWAHYLRYGNFTFFVANGIPYREATTMTLGAIIFSQIGMVMNSRTSYQSIKALSIFGNKLINFGIIMEILAFLVLVYVPLFHNLFNTASLGLSHWLYLISCPFIMIGLDEVRKLFSSRKNKR
>NZ_CP021868.1|WP_000065321.1|987678_988782_+|DUF2974-domain-containing-protein
MSNIITYLKNNSNLTFDELALNDVDILCLNEFGYISFEKLINTTEMKSVLVCELYHEYLQTMAKSYSFMFTSQRHDLCQLMMTSKRFKNLTLSYYRAEISLEFEKQFAAMVFTIPNINYHQVVFRGTDANLIGWKEDFKLTYMREISAHRSAIKYLNTILPYFDKVVLSGHSKGGNLALYAAMFTKPDLKAKIDLIWLIDSPGLQKTLLPTTEYKTTKQKCIRLLPEESIVGMMLYSDIEPLIISSNARGILQHDVTTWEIQEPAILKTGTGLSLKSICFEKTFQQWMAELKSQERKLFFDLLFDSFLSSGVSSLDDFNLASRAKMMKAFHSFRELDDDKKRLFNKSLKLLVTIFWGAYHDNSRETK
>NZ_CP021868.1|WP_000146565.1|988902_989541_-|CatB-related-O-acetyltransferase
MASILKKHLEKRLELKNDPMRTDMSTGASYPKYGFSVGKYTYGYQQFFYEGVNLKEIGAFCSIAQNVTITGLNHPTDHITTNPFIYYKSRGFINEDRADLIDEKKNGKVIIGNDVWIGTNVTILPSVTIGNGAIIGAGSVITKDIPDYAVVAGTPAKIIKYRFSEEEITLLNASQWWNWSDEAIKEHISEFSDKKEFFNTLKSISENKNHKL
>NZ_CP021868.1|WP_001056394.1|990251_990863_+|TVP38/TMEM64-family-protein
MNMKLSKRYRFWQKVIKALGVLALIATLVLVVYLYKLGILNDSNELKDLVHKYEFWGPMIFIVAQIVQIVFPVIPGGVTTVAGFLIFGPTLGFIYNYIGIIIGSVILFWLVKFYGRKFVLLFMDQKTFDKYESKLETSGYEKFFIFCMASPISPADIMVMITGLSNMSIKRFVTIIMITKPISIIGYSYLWIYGGDILKNFLN
>NZ_CP021868.1|WP_000467138.1|990899_991682_-|hypothetical-protein
MFGKLLKYELKSVGKWYLTLNAAVLLVSIILGLVLKALGGNFSTDTNSTSAQIFTIILVLLLAMVISGSLLSTLAIIIKRFYSNIFGRQGYLTLTLPVTTNQIICSKLLASLLWSIFNIFIVIIGIILVILPLVGIGQFVVAFPEIYKIISSSNAPLFIAYFFLSYVAGTLLIYLSIAVGQLFTNKRVLMGIVSYFGISLLITFLTLIIDSIFHIDLFNSHANATFSQPVLLYNILVSIVEIAIFYMLTHSIIKYKLNIQ
>NZ_CP021868.1|WP_000192686.1|991693_992392_-|ABC-transporter-ATP-binding-protein
MTQLLQLHHVTKKYHKHTAVNDVTVSIPTGKIIGLLGPNGSGKTTIIKMINGLLQPDKGDIVIDGYRPSVETKKIISYLPDTSYLQENMKIKDVVTLFEDFYNDFDSKVAYQLFEDLNLNPRERLKNLSKGNKEKVQLILVMSRKARLYILDEPIGGVDPAARDYILKTIISNYSNDASVLISTHLISDIEPILDEVIFLKEGEIDLQGNADDLREEHNCSIDALFRERFKK

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Crispr_ID: NZ_CP021868_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021868_2

1462590-1463202

Orphan

Consensus_repeat	Method
TNGANGCACTCNTTGANGCGCTNGTNCTNGCTGANGT	CRT

8 spacers

The CRISPR arrays of NZ_CP021868_2

>merge|NZ_CP021868|2|1462590-1463202|CRT
TCGATGCACTCGTTGAGACGCTGGTGCTGGCTGACGTCGTGGCACTCATTGAAGCGCTAGTGCTGGCTGACATTGACGCACTCGTTGAAGCGCTGGTGCTGGCTGACGTCGACGCACTCATTGAAGCGCTAGTGCTGGCTGACATCGAGGCACTTGTTGAAGAACTTGTGCTGGCTGACATTGACGCACTCGTTGAGGCGCTAGTGCTAGCTGACGTCGAGGCACTCATTGAAGCGCTAGTGCTGGCTGACATCGAGGCACTTGTTGAAGAACTTGTGCTGGCTGACATTGACGCACTCGTTGAGGCGCTAGTGCTGGCTGACGTCGACGCACTCATGGAAGCACTTGTGCTGGCTGACGTCGAGGCACTCATTGAGGCGCTAGTGCTGGCTGATGTCGATGCACTGGTACTTGCTGACGTGGAAGAACTTGTACTTGCCGATGTTGAGGCGCTAGTACTTGCTGATGTGGAAGCACTCGTACTTGCACTTGTGGAAGCGCTGGTACTTGCTGATGTCGATGCACTCATTGAGGCGCTAGTACTTGCACTTGTGGAAGCACTGGTGCTGGCTGACGTCGATGCACTCATTGAGGCGCTAGTACTTGCTGACGT

>NZ_CP021868|2|2|1462590-1463202|CRT
TCGATGCACTCGTTGAGACGCTGGTGCTGGCTGACGT	CGTGGCACTCATTGAAGCGCTAGTGCTGGCTGACA
TTGACGCACTCGTTGAAGCGCTGGTGCTGGCTGACGT	CGACGCACTCATTGAAGCGCTAGTGCTGGCTGACA
TCGAGGCACTTGTTGAAGAACTTGTGCTGGCTGACAT	TGACGCACTCGTTGAGGCGCTAGTGCTAGCTGACG
TCGAGGCACTCATTGAAGCGCTAGTGCTGGCTGACAT	CGAGGCACTTGTTGAAGAACTTGTGCTGGCTGACA
TTGACGCACTCGTTGAGGCGCTAGTGCTGGCTGACGT	CGACGCACTCATGGAAGCACTTGTGCTGGCTGACG
TCGAGGCACTCATTGAGGCGCTAGTGCTGGCTGATGT	CGATGCACTGGTACTTGCTGACGTGGAAGAACTTG
TACTTGCCGATGTTGAGGCGCTAGTACTTGCTGATGT	GGAAGCACTCGTACTTGCACTTGTGGAAGCGCTGGTACTTGCTGATG
TCGATGCACTCATTGAGGCGCTAGTACTTGCACTTGT	GGAAGCACTGGTGCTGGCTGACG
TCGATGCACTCATTGAGGCGCTAGTACTTGCTGACGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021868.1\|WP_001042316.1\|1471048_1471969_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP021868.1\|WP_000795050.1\|1457431_1458616_-\|glycosyl-transferase-family-8	unknown	unknown	gnl\|CDD\|133037
NZ_CP021868.1\|WP_001263776.1\|1461057_1462065_-\|sugar-transferase	unknown	unknown	gnl\|CDD\|236626
NZ_CP021868.1\|WP_000818887.1\|1474334_1475075_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP021868.1\|WP_000502594.1\|1475665_1475824_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021868.1\|WP_000034864.1\|1450843_1452403_-\|accessory-Sec-system-protein-Asp2	unknown	unknown	gnl\|CDD\|274739
NZ_CP021868.1\|WP_000104405.1\|1449854_1450847_-\|accessory-Sec-system-protein-Asp3	unknown	unknown	gnl\|CDD\|163423
NZ_CP021868.1\|WP_001263851.1\|1455306_1456503_-\|SP_1767-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|163440
NZ_CP021868.1\|WP_001865283.1\|1458605_1459847_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|133037
NZ_CP021868.1\|WP_000681005.1\|1472151_1474335_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|270337
NZ_CP021868.1\|WP_000772257.1\|1453953_1455183_-\|accessory-Sec-system-protein-translocase-subunit-SecY2	unknown	unknown	gnl\|CDD\|237095
NZ_CP021868.1\|WP_088181596.1\|1466228_1467034_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|372577
NZ_CP021868.1\|WP_000130202.1\|1456563_1457439_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_CP021868.1\|WP_000656279.1\|1475223_1475574_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021868.1\|WP_000863865.1\|1477223_1477352_-\|DUF4044-domain-containing-protein	unknown	unknown	gnl\|CDD\|338651
NZ_CP021868.1\|WP_000468350.1\|1452409_1453954_-\|accessory-Sec-system-protein-Asp1	unknown	unknown	gnl\|CDD\|293598
NZ_CP021868.1\|WP_000567072.1\|1468996_1470988_-\|excinuclease-ABC-subunit-B	unknown	unknown	gnl\|CDD\|235395
NZ_CP021868.1\|WP_000061665.1\|1475849_1477163_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237046
NZ_CP021868.1\|WP_088181610.1\|1467403_1468900_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NZ_CP021868.1\|WP_000751406.1\|1459843_1461049_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133037

Protein	Function_ID	Function_description	E-value
NZ_CP021868.1\|WP_001042316.1\|1471048_1471969_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.55469e-11
NZ_CP021868.1\|WP_000795050.1\|1457431_1458616_-\|glycosyl-transferase-family-8	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	2.05657e-73
NZ_CP021868.1\|WP_001263776.1\|1461057_1462065_-\|sugar-transferase	gnl\|CDD\|236626	PRK09814, PRK09814, sugar transferase.	1.32907e-150
NZ_CP021868.1\|WP_000818887.1\|1474334_1475075_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.4733e-157
NZ_CP021868.1\|WP_000034864.1\|1450843_1452403_-\|accessory-Sec-system-protein-Asp2	gnl\|CDD\|274739	TIGR03712, acc_sec_asp2, accessory Sec system protein Asp2. This protein is designated Asp2 because, along with SecY2, SecA2, and other proteins it is part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NZ_CP021868.1\|WP_000104405.1\|1449854_1450847_-\|accessory-Sec-system-protein-Asp3	gnl\|CDD\|163423	TIGR03711, acc_sec_asp3, accessory Sec system protein Asp3. This protein is designated Asp3 because, along with SecY2, SecA2, and other proteins it is part of the accessory Sec system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	7.04012e-61
NZ_CP021868.1\|WP_001263851.1\|1455306_1456503_-\|SP_1767-family-glycosyltransferase	gnl\|CDD\|163440	TIGR03728, glyco_access_1, glycosyltransferase, SP_1767 family. Members of this protein family are putative glycosyltransferases. Some members are found close to genes for the accessory secretory (SecA2) system, and are suggested by Partial Phylogenetic Profiling to correlate with SecA2 systems. Glycosylation, therefore, may occur in the cytosol prior to secretion.	1.6115e-160
NZ_CP021868.1\|WP_001865283.1\|1458605_1459847_-\|glycosyl-transferase	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	4.60076e-75
NZ_CP021868.1\|WP_000681005.1\|1472151_1474335_+\|ABC-transporter-permease-subunit	gnl\|CDD\|270337	cd13619, PBP2_GlnP, Glutamine-binding domain of ABC transporter, a member of the type 2 periplasmic binding fold protein superfamily. Periplasmic glutamine binding domain GlnP serves as an initial receptor in the ABC transport of glutamine in eubacteria. GlnP belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.85761e-106
NZ_CP021868.1\|WP_000772257.1\|1453953_1455183_-\|accessory-Sec-system-protein-translocase-subunit-SecY2	gnl\|CDD\|237095	PRK12417, secY, preprotein translocase subunit SecY; Reviewed.	1.15376e-161
NZ_CP021868.1\|WP_088181596.1\|1466228_1467034_+\|IS5-family-transposase	gnl\|CDD\|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.3964e-22
NZ_CP021868.1\|WP_000130202.1\|1456563_1457439_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	3.18211e-33
NZ_CP021868.1\|WP_000863865.1\|1477223_1477352_-\|DUF4044-domain-containing-protein	gnl\|CDD\|338651	pfam13253, DUF4044, Protein of unknown function (DUF4044). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 56 amino acids in length. There is a single completely conserved residue M that may be functionally important.	1.85741e-06
NZ_CP021868.1\|WP_000468350.1\|1452409_1453954_-\|accessory-Sec-system-protein-Asp1	gnl\|CDD\|293598	pfam16993, Asp1, Accessory Sec system protein Asp1. Asp1, along with SecY2, SecA2, and other proteins forms part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. Asp1 is predicted to be cytosolic.	0
NZ_CP021868.1\|WP_000567072.1\|1468996_1470988_-\|excinuclease-ABC-subunit-B	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP021868.1\|WP_000061665.1\|1475849_1477163_-\|GTPase-ObgE	gnl\|CDD\|237046	PRK12297, obgE, GTPase CgtA; Reviewed.	0
NZ_CP021868.1\|WP_088181610.1\|1467403_1468900_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	3.69142e-24
NZ_CP021868.1\|WP_000751406.1\|1459843_1461049_-\|hypothetical-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	1.83116e-68

>NZ_CP021868.1|WP_001263776.1|1461057_1462065_-|sugar-transferase
MRVHITSIYGQSPRSIALISQKLVKDVGRQLGYDEMGIYFYNDHAETHGERSTRMDGIIAGLGRGDIVVFQVPTWNSTEFDELFLDKLQAYGARIITFVHDIVPLMFESNFYLLDRVIDMYNRSDVVILPTKAMHDYLIEKGMTTSKVLYQEVWDHPVNIDLPRPECQKVLSFAGDIQRFPFVNDWKENIPLIYYGDGSRLNSEANVHAQGWKDDVELMLSLSKRGGFGLCWSEDREELVERRYSRMNASYKLSTFLAAGLPIIANHDISSRDFIKQHGLGFTVETLEEAVEKINNMEKETYDSYVENVEKIATLLRNGYITKKLLIDAVHMLYR
>NZ_CP021868.1|WP_000751406.1|1459843_1461049_-|hypothetical-protein
MKKTIVLGADFQYRDQVMTTIKSIVSHNQHLTIYIINTDFPVEWFNILNHSLEQFDCRVKNIPISSDVFEGIPTLSHISVAGFFRWFILIHLEEEIVLYLDSDVIVRGSLDPLFDINLEENLLGAVADHFSTLYYGDTAPVSFNSGVMLINNSLWKKEEIYNSLMRIADKGSAVGVGDQEYLNILTQNRWIDIGKQYNVQIGQDVNINAYGRPDLYHFYDDCEPVIVHYNSQDKPWNKYSQSRYRSEWWYYFGLEWSVIYAQQQKNLNRLTGKTLNLFTLTASDTLEHIEVLAKALPDYQFHIAARSDISEKLANLETYSNIKVYKLVINPILEELIRNCDVYLDINHSYEVEGILDKIKEENKPILAFDSTAHTTKNIEVISETMPELMVKRIREVGPLR
>NZ_CP021868.1|WP_001865283.1|1458605_1459847_-|glycosyl-transferase
MKNRKAIALAADFGYQEQVKTIIKSICFHNQFIDFYILNDDFPVEWFQMMEYHLSKMDCTISNTKIFNEEIKHFKFQKPMPYPTYFRYFIPEVIHEDKVLYLDCDMIITSDLTSIFTLDISKYGVAAVRDDLLEEYDGKEDYFNSGLLLINNIFWREQGISQRLLDYTRENQGALQYHDQDVLNDVLCDNWLELDETYNYHTGADMLYNLFQQSERQLNRRKDLPKVIHYTATKPWKYLETSVRWRDIWWEYNRLEWRDIFTRWQVNDGVDVSLKKVLQPIHRAFIFTYSDSIEGIERLAKDLPNWQFHIAAYTQISEKLKQLEMHSNIKLYPLVYRFKLNELVENSDIYLDINHGDADTQVLEQVKKLGKDILSLSTTYHGQGKQFERVTDIIDYLKNERFKEHIRKEYCEK
>NZ_CP021868.1|WP_000795050.1|1457431_1458616_-|glycosyl-transferase-family-8
MKNNVICLAGDNKSLNQIQTVIKSILCHNDRVSIYILNQDIASEWFRNIQRRLLNSHSCIFDIKLFDDTFKEFKTPRAHITYMAYARYYIPQLIDAEKVLYLDIDTLVVDNLDKLFEIELGDYPIAAILDGDGIHFNSGVMLINSLYWMRYRVTEKLLEITERELDNGIFGDQGVLNLLFDNNWLKLEDKYNAQVGNDLGAFYENWQGYFDRNFESPTIIHYCTHDKPWNTFSSSRFRETWWQYEQLDWNEVFNFETYLLPEPTFEKHFFTFTTSVDLLYIEELVELFPNSCFHIAAWTSFGPRLLKLATNSNVRLYPSITSPLFEQLMTKANYYLDISTSWKEIQFCQKAIEKSIPILSFNEAVTFEYRELSHCFINLEDMRQFLCKNGGNSD
>NZ_CP021868.1|WP_000130202.1|1456563_1457439_-|glycosyltransferase-family-2-protein
MTDKLVSVIIPVYNAAPYLEGCVNTILGQTYQVFEILLIDDGSTDTSASICDQLSLRDNRIRVFHIENGGASKARNFGLARISPESQFVTFVDSDDWVKENYLEVLLAQQEKYNADIVISNYYIYRETEDIFGYYITDKDFVIEEISAQTAIDRQVHWHLNSSVFIVIWGKLYRRELFDTITFPIDKVFEDELVSVLLFIKSKKTILVNGSYYGYRIRPNSIMTSAFSSKIAEDLIYIFDSKLSEIILSGLDSTATVERYFWLMRDYKQRLEQENLQKTIIYKVISNRLSR
>NZ_CP021868.1|WP_001263851.1|1455306_1456503_-|SP_1767-family-glycosyltransferase
MRVIKVKTISETLDYISKHTASVARFGDGEIDIIAGNSIPYQVYDSELAKRLERLLNRQSNEKLVICVSDVFDNLGRYNDFSQQFWRDHLYQYNDLYQKNCQAEWYGSTFISRPYMDLLDKSLSVTYFEQLKALWKNKDILIVEGETSRSGVGNDLFNDANTISRIICPSKDAFSSFYEIKETILEHSRGKLILLMLGPTAKLLAEDLSQLGHQAIDLGHIDSEYEWFKMGAVSKVKLSHKHTAEHNFDEDITLIEDNSYENQIVSKIGTSDRQYALTVTLTDDIWELEHLLQRCPNTNFHIAAPVYCSDRLKQLVGYPNYYLHEAITEEQFEVLLLNSDIYLDINHGEEVWNIVDRCITEGKTIYGIRRARKDNQYISFERTMDDFEYLCDTIKQNR
>NZ_CP021868.1|WP_000772257.1|1453953_1455183_-|accessory-Sec-system-protein-translocase-subunit-SecY2
MKLLYIFEKNIILRKILITFSLIIIFLLGRYVPIPGVLISAYKGQDNNFATLYSTVTGGNLSQVGVFSLGIGPMMTTMILLRLFTIGKYSSGVSQKVQQFRQNVVMLVIAIIQGLAIAISFQYHNGFSLTKLLLATMILVTGAYIISWIGNLNAEYGFGGMTILVVVGMLVGQFNNIPLIFELFQDGYQLAIILFLLWTLVAMYLMITFERSEYRIPVMRTSIHNRLVDDAYMPIKVNASGGMAFMYVYTLLMFPQYIIILLRSIFPTNPDITSYNDYFSLSSIQGVVIYMILMLVLSVAFTFVNIDPTKISEAMRESGDFIPNYRPGKETQSYLSKICYLFGTFSGFFMAFLGGVPLLFALGNDDLRTVSSMTGIFMMITGMSFMILDEFQVIRIRKQYTSVFENEEN
>NZ_CP021868.1|WP_000468350.1|1452409_1453954_-|accessory-Sec-system-protein-Asp1
MFHFIPSWYNENRTWYDNNYLWYFKPTNVGFDDTINQMKMFDYAGKESRLVVLNYMPNLRYYLHRYDLLESGYYSVFDDIQEIGNVRQQMIDFRQLNWPEGVDFTYTPFIVLVKKSGDLIAKVQFGEEGNLTHIDYFANEQIAKKYLFDDRGFLSSILYYDNGGEAYQDYLAPSGERIMREYLREGDHHVEINPKKAIHFLKLSYSDIEELIREKYLTYLHKEVSKSDTIIVSFNQVHNAFIVGNTSKGNLILSVFSERNNAHNVLEDYSSLSRANAIICDRLDIAAQLKEKIDKPVVHVSPFDTRLALGKSNQVRDLEIYFVVDRLSHKELQKSLTSLYKVMLKNNDIKVTFVSYEREFESRQLTYDYLKEATKVFDQKFFSLSDDDANQVLMQSDEVEKEKTRLSFTHPLSETDIINRLEYVRLIIDISKIPDLYTQIAGISSGIPQINTILTEFVEHRKNGYVIEEIQELEKAIPYYCEQLTNWNRSLIYSIDKINDYTGGQLVERIINSY
>NZ_CP021868.1|WP_000034864.1|1450843_1452403_-|accessory-Sec-system-protein-Asp2
MSKIKLTILQVGEENWATKENIPNNMEWLFIKPDQISDFVTTENNYLTSSKLLQKLPRKISALLLTEQTYGPELSSLSSFFEVYEVFYPKDKHATGITEEFLRSKMAQRYDSSSPDQLIRQFYKGLFIGQYGEKLQVSQIQIRNDFEGVVNYQGNNYLELEGQFGENYSFLLNFAYNIPFSSDFYNELFLEHIIEGDIDIRLVISLIVDGSVDDIAKEWYFEKEDLNQLISLESDISGSLAVKLFAKGKGIVKLGPLHRRNGRGGLGTFLLGGERHIDAIGHEFMTYFDPVDFKPPLTVYFSGFRSAEGFEGFWMMKSMKTPFMLICDPRLQGGAFYIGSKEYEQKIVDAIQEKLAFLNFSSDQLILSGLSMGTYGATYHGAKLNPHAIIIGKPIFNLGTVAQRERLERPDGFATSLDIQLLNQGDLTSSSSEKLNNYFWKSIEEGDFSNTTFALAYMKNDDYDATAFSDLLQYFRGKKHKILGRGWDGRHGDCSAEVGAWFTSQYRRMLSNDFGRKEE
>NZ_CP021868.1|WP_000104405.1|1449854_1450847_-|accessory-Sec-system-protein-Asp3
MSTISYIYWDDFSRFSYNFGTKLQFLGKSVCFENPLAPSSTNLYTWSSQTNYQSKRISPNLPLLRKGTRYSLSLNAELDLVSSLFVRIEFYNRFNESVGFELLKKDSIIFIYPKEAYTYTISLINAGCSDFTFHYLKLEEVTDSVIQEKNLSTEFTIEEHQDVLNLLLVEKKDSVYINKIESISQLQQKVELVSNPSLNSDSLILPKLEKGLEDALKVFPNIKINVIAYGTQGNFAALYYAKKFPRITAYINDCFAPFGILLKSLPHLTAKQQIFLREVWDTRETSPNVKHYGLVSENSSLNLVSMILSGNEHLPYLTLLKKQDDNYDSL
>NZ_CP021868.1|WP_088181596.1|1466228_1467034_+|IS5-family-transposase
MNYEASKQLTDVRFKRLVGVQRTTFEEMLAVLKTAYQRKHAKGGRTPKLSLEDLLMATLQYMREYRTYEQIAADFGIHESNLIRRSQWVESTLIQSGFTISKTHLSAEDTVIVDATEVKINRPKKQLANYSGKKKCHAMKAQAIVTSQGRIVSLDIAVNYCHDMKLFKMSRRNIGQAAKILADSGYQGIMKMYSQAQTPRKSSKLKPLTLEDKTYNHTLSKERIKVENIFAKVKTFKIFSTTYRNRRKRFGLRMNLIAGMINRELGF
>NZ_CP021868.1|WP_088181610.1|1467403_1468900_+|helix-turn-helix-domain-containing-protein
MIENFLEKNILNKVKLLTLCYDTPSLSLDTACNRLHLSPVELKNYCHKLNVLFGHKLSIHIQKERILCKLNKLTQEDALKIVYNESNTLQLLKFLIDDSSDKKSLVAFGNDLFLSRSSVYRLRENLIPLIKDLGLSLSKNTIVGDDYRIRYLIAYLTTKFGIKIYDLSALDIKIIRQFLFESGTNIRPTTHLSDIFIFFDTLFILTWKRHHHKVKIPNSKLFSSLKKIFIYEELNTCVKSIVQPYFNVIFNSEDMDYIFLIYLTSANSFAAQKWTETHVDEVLAIFKSLPKFQMLLQPLKEALPYSDTYYDELVKVTIYFSRNFIVGLNQLIPETLSFPSTFYPGNNPKLISIIEPIVTHWLTEIGESKFKKTHFFLLCAHLERVIKNSMPPINIVLLTTDFINNEILKDYILQSLSTDKIRFHSYYLLTDNISQISTLKPDLIITNRKLFTYVTKELATNSLVAHIDYNDTPSQISNIQTIISNIKEEKYRKIFDKI
>NZ_CP021868.1|WP_000567072.1|1468996_1470988_-|excinuclease-ABC-subunit-B
MIDRKDTNRFKLVSKYSPSGDQPQAIETLVDNIEGGEKAQILKGATGTGKTYTMSQVIAQVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSVVSLRPGQEISRDQLLNNLVDIQFERNDIDFQRGKFRVRGDVVEVFPASRDEHAFRIEFFGDEIDRIREIESLTGRVLGEVEHLAIFPATHFMTNDEHMEEAISKIQAEMENQVELFEKEGKLIEAQRIRQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPFTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMEQTDTVVEQIIRPTGLLDPEVEVRPSMGQMDDLLGEINLRTEKGERTFITTLTKRMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSNGHVIMYADKITDSMQRAMDETARRRRLQMDYNEKHGIVPQTIKKEIRDLIAITKSNDSDKPEKVVDYSSLSKKERQAEIKALQQQMQEAAELLDFELAAQIRDVILELKAID
>NZ_CP021868.1|WP_001042316.1|1471048_1471969_-|CPBP-family-intramembrane-metalloprotease
MNKRILNSQFAVYKNWPSWLLLLFACFMVYLFFFVGLTLGGVGIVLVSSVLYKFSSYTFFEFINLFNNIYGELGTFSFSAFLLLIWVKFVEKRPFSELGFSTKFKRTLWSLIKGWSIGFILFSISVITAYILGGLDFHSYDVSKATIFYVVTLLPFWLIQSGTEELLTRGWLLPLINHRFHLAVAIGVSSTLFGILHLVNAHVTFLSIVSIICSGVLMSLYMIKSGNIWSVAALHGAWNFSQGNLYGIAVSGQKAGASLLHFTVKENAPDWISGGAFGIEGSLISIFVLLAAIIYLLWLIKTEETD
>NZ_CP021868.1|WP_000681005.1|1472151_1474335_+|ABC-transporter-permease-subunit
MKHKLKAFTLALLSIFFVFGGKVSAETVNIVSDTAYAPFEFKDSDQTYKGIDVDIVNEVAKRAGWNVNMTYPGFDAAVNAVQSGQADALMAGTTVTEARKKVFNFSDTYYDTSVILYTKNNNKVTNYKQLKGKVVGVKNGTAAQSFLEENKSKYGYKVKTFDTSDLMNNSLDSGSIYAAMDDQPVVQFAINQGKAYAINMEGEAVGSFAFAVKKGSGHDNLIKEFNTAFAQMKSDGTYNDIMDKWLGKDATKTSGKATGNANEKATPVKPSYKIVSDSSFAPFEYQNGKGKYTGFDMELIKKIAKQQGFKLDISNPGFDAALNAVQSGQADGVIAGATITEARQKIFDFSDPYYTSSVILAVKKGSNVKSYQDLKGKTVGAKNGTASYTWLSDHADKYNYHVKAFDEASTMYDSMNSGSIDALMDDEAVLAYAINQGRKFETPIKGEKSGDIGFAVKKGANPELIKMFNNGLASLKKSGEYDKLVKKYLSTASTSSNDKAAKPVDESTILGLISNNYKQLLSGIGTTLSLTLISFAIAMVIGIIFGMMSVSPSNTLRTISMIFVDIVRGIPLMIVAAFIFWGIPNLIESITGHQSPINDFVAATIALSLNGGAYIAEIVRGGIEAVPSGQMEASRSLGISYGKTMQKVILPQAVRLMLPNFINQFVISLKDTTIVSAIGLVELFQTGKIIIARNYQSFRMYAILAIMYLVIITLLTRLAKRLEKRLK
>NZ_CP021868.1|WP_000818887.1|1474334_1475075_+|amino-acid-ABC-transporter-ATP-binding-protein
MAELKIDVQDLHKSYGQNEVLKGIDAKFYEGDVVCIIGPSGSGKSTFLRTLNLLESITSGKVVVDGFELSNPKTDIDKARENIGMVFQHFNLFPHMSVLENITFAPIELGKESKEAAEKHGMELLEKVGLADKANAKPDSLSGGQKQRVAIARSLAMNPDILLFDEPTSALDPEMVGDVLNVMKDLAEQGMTMLIVTHEMGFARQVANRVIFTDGGRFLEDGTPEQIFDTPQHPRLQDFLNKVLNV
>NZ_CP021868.1|WP_000656279.1|1475223_1475574_+|hypothetical-protein
MKDYINRILHFIKEHMTYHVNFIDDFLDIKWEKVSNIHLRFWTTIIAYLVIFILSISTVILNLVLLFQGFLTQNPIIYLLFFITLVCAFYFAYKFITYTPTIVKNALQYIKKLKNV
>NZ_CP021868.1|WP_000502594.1|1475665_1475824_-|hypothetical-protein
MGDKPISFRDKDGNFVSAADVWNAEKLEELFNTLNPNRKLRLEREKLAKEKG
>NZ_CP021868.1|WP_000061665.1|1475849_1477163_-|GTPase-ObgE
MSMFLDTAKISVKAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFKVNEGLRTLMDFRYNRNFKAKAGEKGMTKGMHGRGAEDLIVSLPPGTTVRDATTGKVITDLVEHDQEFVVARGGRGGRGNIRFATPRNPAPEIAENGEPGEERELQLELKILADVGLVGFPSVGKSTLLSVVSAAKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVILHVIDMSASEGRDPYDDYVSINNELETYNLRLMERPQIIVANKMDMPDSEENLAAFKEKLAANYDEFDDMPMIFPISSLAHQGLENLMDATAELLANTEEFLLYDETDMQEDEAYYGFNEDERPFEITRDDDATWVLYGDKLEKLFVMTNMERDESIMKFARQLRGMGVDEALRERGAKDGDIVRIGNFEFEFVD
>NZ_CP021868.1|WP_000863865.1|1477223_1477352_-|DUF4044-domain-containing-protein
MAFGDNGQRKKTGFEKLTLFVVILMVLVTVGGLVFGAISAIM

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Crispr_ID: NZ_CP021868_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021868_3

2017676-2018089

Orphan

Consensus_repeat	Method
TTTAGCTTCTGGNTTNGC	CRT

7 spacers

The CRISPR arrays of NZ_CP021868_3

>merge|NZ_CP021868|3|2017676-2018089|CRT
TTTGGTTTCTGGTTTAGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAGCTTCTGGCTTAGCTTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGCTTAGCCTCTGGTTTGGCTTCTGGTTTAGCCTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAGCTTCTGGCTTAGCTTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACTTCTGGCTTAGCTTCTGGCTTAGCCTCTGGTTTAGCTTCTGGCTTAGCCTCTGGTTTAGCTTCTGGCTTAGCCTCTGGTTTGGCCTCTGGCTTAAC

>NZ_CP021868|3|3|2017676-2018089|CRT
TTTGGTTTCTGGTTTAGC	CTCTGGCTTAACGTCTGGTTTAACTTCTGG
TTTAACTTCTGGTTTGGC	TTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGGTTTAGCTTCTGG
CTTAGCTTCTGGTTTGGC	CTCTGGCTTAACGTCTGGTTTAACTTCTGGCTTAGCCTCTGGTTTGGCTTCTGG
TTTAGCCTCTGGTTTGGC	CTCTGGCTTAACGTCTGGTTTAACTTCTGGTTTAACTTCTGGTTTGGCTTCTGG
TTTAGCTTCTGGCTTAGC	TTCTGGTTTGGCCTCTGGCTTAACGTCTGG
TTTAACTTCTGGCTTAGC	TTCTGGCTTAGCCTCTGG
TTTAGCTTCTGGCTTAGC	CTCTGGTTTAGCTTCTGGCTTAGCCTCTGG
TTTGGCCTCTGGCTTAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021868.1\|WP_001093382.1\|2003782_2008495_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173801
NZ_CP021868.1\|WP_000764803.1\|2019873_2022195_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP021868.1\|WP_000074731.1\|2014467_2015715_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP021868.1\|WP_000610954.1\|2002454_2002778_-\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226827
NZ_CP021868.1\|WP_000453154.1\|2026235_2026907_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234784
NZ_CP021868.1\|WP_000887149.1\|2016740_2017280_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP021868.1\|WP_001182060.1\|2028159_2028939_-\|uridine-phosphorylase	unknown	unknown	gnl\|CDD\|350167
NZ_CP021868.1\|WP_000077187.1\|2024957_2026169_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_CP021868.1\|WP_000497678.1\|2019463_2019637_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|223762
NZ_CP021868.1\|WP_001159688.1\|2026936_2028139_-\|NupC/NupG-family-nucleoside-CNT-transporter	unknown	unknown	gnl\|CDD\|224883
NZ_CP021868.1\|WP_000903268.1\|2010891_2011500_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021868.1\|WP_000730418.1\|2009410_2010799_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP021868.1\|WP_000057521.1\|2019672_2019825_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP021868.1\|WP_001125582.1\|2029096_2029834_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP021868.1\|WP_000459245.1\|2023147_2024788_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226987
NZ_CP021868.1\|WP_000161340.1\|2008727_2009414_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP021868.1\|WP_000145170.1\|2011589_2014091_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP021868.1\|WP_000953621.1\|2015757_2016603_-\|patatin-family-protein	unknown	unknown	gnl\|CDD\|132847
NZ_CP021868.1\|WP_000010476.1\|2022238_2023123_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP021868.1\|WP_000410674.1\|2002767_2003460_-\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215

Protein	Function_ID	Function_description	E-value
NZ_CP021868.1\|WP_001093382.1\|2003782_2008495_+\|S8-family-serine-peptidase	gnl\|CDD\|173801	cd07475, Peptidases_S8_C5a_Peptidase, Peptidase S8 family domain in Streptococcal C5a peptidases. Streptococcal C5a peptidase (SCP), is a highly specific protease and adhesin/invasin. The subtilisin-like protease domain is located at the N-terminus and contains a protease-associated domain inserted into a loop. There are three fibronectin type III (Fn) domains at the C-terminus. SCP binds to integrins with the help of Arg-Gly-Asp motifs which are thought to stabilize conformational changes required for substrate binding. Peptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.74688e-89
NZ_CP021868.1\|WP_000764803.1\|2019873_2022195_-\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	0
NZ_CP021868.1\|WP_000074731.1\|2014467_2015715_+\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.90301e-69
NZ_CP021868.1\|WP_000610954.1\|2002454_2002778_-\|AzlD-domain-containing-protein	gnl\|CDD\|226827	COG4392, COG4392, Predicted membrane protein [Function unknown].	3.7427e-14
NZ_CP021868.1\|WP_000453154.1\|2026235_2026907_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	3.25832e-110
NZ_CP021868.1\|WP_000887149.1\|2016740_2017280_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.00072e-83
NZ_CP021868.1\|WP_001182060.1\|2028159_2028939_-\|uridine-phosphorylase	gnl\|CDD\|350167	cd17767, UP_EcUdp-like, uridine phosphorylases similar to Escherichia coli Udp and related phosphorylases. Uridine phosphorylase (UP) is specific for pyrimidines, and is involved in pyrimidine salvage and in the maintenance of uridine homeostasis. In addition to E. coli Udp, this subfamily includes Shewanella oneidensis MR-1 UP and Plasmodium falciparum purine nucleoside phosphorylase (PfPNP). PfPNP is an outlier in terms of genetic distance from the other families of PNPs. PfPNP is catalytically active for inosine and guanosine, and in addition, has a weak UP activity. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	4.65794e-137
NZ_CP021868.1\|WP_000077187.1\|2024957_2026169_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP021868.1\|WP_000497678.1\|2019463_2019637_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|223762	COG0690, SecE, Preprotein translocase subunit SecE [Intracellular trafficking and secretion].	5.81702e-09
NZ_CP021868.1\|WP_001159688.1\|2026936_2028139_-\|NupC/NupG-family-nucleoside-CNT-transporter	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	3.49248e-155
NZ_CP021868.1\|WP_000730418.1\|2009410_2010799_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.80415e-45
NZ_CP021868.1\|WP_000410674.1\|2002767_2003460_-\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	1.19476e-51
NZ_CP021868.1\|WP_001125582.1\|2029096_2029834_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	6.94122e-33
NZ_CP021868.1\|WP_000459245.1\|2023147_2024788_-\|hypothetical-protein	gnl\|CDD\|226987	COG4640, COG4640, Predicted membrane protein [Function unknown].	3.0337e-08
NZ_CP021868.1\|WP_000161340.1\|2008727_2009414_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.70608e-62
NZ_CP021868.1\|WP_000145170.1\|2011589_2014091_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP021868.1\|WP_000953621.1\|2015757_2016603_-\|patatin-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	8.616e-122
NZ_CP021868.1\|WP_000010476.1\|2022238_2023123_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.14066e-85
NZ_CP021868.1\|WP_000057521.1\|2019672_2019825_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.53308e-18

>NZ_CP021868.1|WP_000887149.1|2016740_2017280_-|transcription-termination/antitermination-protein-NusG
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPTQTVNVEKNGKTKEIEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRSILISMGQTVDVFDTNIKEGDVVQIIDGAFIGQEGRVVEIENNKVKLMINMFGSETQAELELYQVAEL
>NZ_CP021868.1|WP_000953621.1|2015757_2016603_-|patatin-family-protein
MLSVGLVLEGGGMRGLYTAGVLDAFLDAGIKIDGIVSVSAGALFGVNFVSRQRERALRYNKKYLSHPEYMSLRSWLRTGNFVNKDFTYYEVPMKLDVFDDEAFKKSSIDFYVVATEMTSGKPEYFKIDSVFEQMEILRASSALPVVSKMVDWQGKKYLDGGLSDSIPVDFARGLGFDKLIVVMTRPLNYQKKPSSGRLYKTLYRKYPNFVKTASNRYQQYNNSLEKVMSLEKIGDLFAIRPSKSLVIGRLEKNPDKLDSIYQLGMKDAKSVMPELNSYLMK
>NZ_CP021868.1|WP_000074731.1|2014467_2015715_+|MFS-transporter
MSPLNINKNNWRALIAAIVASGTDDLNIMFLAFSMSTIITDLHLSAAQAGWIGTITNLGMLVGGLIFGLLADRYNKFKVFKWTILIFSIATGLVFFTTNLSYLYIMRFIAGIGVGGEYGIAIAIMAGIVPANKMGRISSLNGIAGQVGSISSALLAGWLAPALGWRGLFLFGLLPIVLVLWMQFAIDDKDILDQYNTDADDEPLDISIKALFDTPVLATQSLALMVMTTVQIAGYFGMMNWLPTIIQTNLNVSVKNSSLWMIATILGMCLGMLVFGQLLDKFGPRLVYGCFLLSSAICVYLFQFATTMPSMIIGGAVVGFFVNGMFAGYGAMITRLYPHHIRSTANNLILNVGRAIGGFSSVIIGMILDVSNVSMVMLFLASLYIVSFLSMLSIKQLKRQKYHTNLTQLDVKPTD
>NZ_CP021868.1|WP_000145170.1|2011589_2014091_-|leucine--tRNA-ligase
MTFYNHKEIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTAPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTDKDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVAEYKRQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFKLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKAAAIAKMVEWLEVEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITKENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHLGEELWQVLTASGESISYVPWPSYDESKLVENEIEIVVQIKGKVKAKLVVAKDLSREELQELALANEKVQAEIAGKDIIKVIAVPNKLVNIVVK
>NZ_CP021868.1|WP_000903268.1|2010891_2011500_+|hypothetical-protein
MLHSKKIHSLSLIAVLSLATYTSLQPNHVTAEQSQKTSTVHMSQKTIEHKLKVADKEAAPLYAKIDHIQRHIEVKKAKDLKVIELYINKDINQLEKQNKRLLTKFYTSIDNQTWDSTSEVKKLIDKTNLSTNEKDRLKLYFEQRAYLETRLNDRYQKFDNSIENQNKELKILTSKIEKIYQKHGITKEVLKTYYAKKTVRAD
>NZ_CP021868.1|WP_000730418.1|2009410_2010799_+|HAMP-domain-containing-histidine-kinase
MKKKSLISNLILINSITLFLGFYLIYFSVNYVIKDYVHQMTRNSMQANFTILDSIYNNKKIPDENMVNQDSIFVWSYYAIFDQHYRMKYGTDNHKKESHDIIRYLTQKRLWQISKEKDGMFVTIKKKTYYVMTKDYSGILVDGSIKKVPKAQSQLFHVINFSDITYTQHLITKINHFLIVILVLTYIPMLFIMRKTFTGIRESIQSVQTYISSLWKNQGNHQSSQKEIVFSDFDPLLLESQEMANRIYQAEESQRNFFQNASHELRTPLMSIQGYTEGVQEGIIDAELAHSVILQESKKMKQLVDDIILLSKLDSNLSNQKDEFSLNELLNSIIAYFKPLANKQKISITYRPDKHEKLLKGNEELIQRAINNILSNALRYAVSHIKISYTNQKLTISNDGPAISKEDLPYIFDRFYKGHGGQTGIGLAMTKEIIKQHHGNIIAESDSTSTTFTIYFNCHKIA
>NZ_CP021868.1|WP_000161340.1|2008727_2009414_+|response-regulator-transcription-factor
MTKIIYFADDEKNIRDLVVPFLEHDGFTVRAFETGDLLLEAYKNQKPDLVILDIMMPGTNGLDVMKSIRQYDNIPIIMLTARDSDVDFITAFNLGTDDYFTKPFSPIKLSLHVKALFKRLDEKAIKNNTQYQFLDLILDTEKRIALLSNEEMPLTKTEFDFLLVLIKKPETAFSRETLLNRIWGFDDIESRAVDDTIKRLRKKFKQYHSQVSIKTVWGYGFKLIKEDK
>NZ_CP021868.1|WP_001093382.1|2003782_2008495_+|S8-family-serine-peptidase
MNTKQRFSIRKYKLGAVSVLLGTLFFLGGITNVAADSVINKPSDIAVEQQVKDSPTSIANETPTNNTSSALASTAQDNLVTKANNSPTETQPVAESHSQATETFSPAANQPVESTQEVSKTPLTKQNLAVKPTPAISKETPQNIDSNKIITVPKVWNTGYKGEGTVVAIIDSGLDTNHDALQLNDSTKAKYQNEQQMNAAKAKAGINYGKWYNNKVIFGHNYVDVNTELKEVKSTSHGMHVTSIATANPSKKDTNELIYGVAPEAQVMFMRVFSDEKRGTGPALYVKAIEDAVKLGADSINLSLGGANGSLVNADDRLIKALEMARLAGVSVVIAAGNDGTFGSGASKPSALYPDYGLVGSPSTAREAISVASYNNTTLVNKVFNIIGLENNKNLNNGLAAYADPKVSDKTFEVGKQYDYVFVGKGNDNDYKDKTLNGKIALIERGDITFTKKVVNAINHGAVGAIIFNNKAGEANLTMSLDPEASAIPAIFTQKEFGDVLAKNNYKIVFNNIKNKQANPNAGVLSDFSSWGLTADGQLKPDLSAPGGSIYAAINDNEYDMMSGTSMASPHVTGATALVKQYLLKEHPELKKGDIERTVKYLLMSTAKAHLNKDTGAYTSPRQQGAGIIDVAAAVQTGLYLTGGENNYGSVTLGNIKDKISFDVTVHNINKVAKDLHYTTYLNTDQVKDGFVTLAPQQLGTFTGKTIRIEPGQTQTITIDIDVSKYHDMLKKVMPNGYFLEGYVRFTDPVDGGEVLSIPYVGFKGEFQNLEVLEKSIYKLVANKEKGFYFQPKQTNEVPGSEDYTALMTTSSEPIYSTDGTSPIQLKALGSYKSIDGKWILQLDQKGQPHLAISPNDDQNQDAVAVKGVFLRNFNNLRAKVYRADDVNLQKPLWVSAPQEGDKNYYSGNTENPKSTFLYDTEWKGTTTDGIPLEDGKYKYVLTYYSDVPGSKPQQMVFDITLDRQAPTLTTATYDKDRRIFKARPAVEHGESGIFREQVFYLKKDKDGHYNSVLRQKGEDGILVEDNKVFIKQEKDGSFILPKEVNDFSHVYYTVEDYAGNLVSAKLEDLINIGNKNGLVNVKVFSPELNSNVDIDFSYSVKDDKGNVIKKQHHGKDLNLLKLPFGTYTFDLFLYDEERANLISPKSVTVTISEKDSLKDVLFKVNLLKKAALLVEFDKLLPKGATVQLVTKTNTVVDLPKATYSPTDYGKNIPVGDYRLNVTLPSGYSTLENLDDLLVSVKEGQVNLTKLTLINKAPLINALAEQTDIITQPVFYNAGTHLKNNYLANLEKAQTLIKNKVEQTSIDNAIAALRESRQALNGKETDTSLLAKAILAETEIKGNYQFVNASPLSQSTYINQVQLAKNLLQKPNVTQSEVDKALENLDIAKNQLNGHETDYSGLHHMIIKANVLKQTSSKYQNASQFAKENYNNLIKKAELLLSNRQATQAQVEELLNQIKATEQELDGRDRVSSAENYSQSLNDNDSLNTTPINPPNQPQALIFKKGMTKESEVAQKRALGVTSQTDNQKVKTNKLPKTGESTPKITYTILLFSLSMLGLATIKLKSIKRE
>NZ_CP021868.1|WP_000410674.1|2002767_2003460_-|AzlC-family-ABC-transporter-permease
MEKGFKDGVKDALPTALGYISIGLAFGIVASASDLSAIEVGLMSALVYGGSAQFAMCALLLAKADLMTITMTVFLVNLRNMLMSLHATTIFKSAHLMNQLAIGTLITDESYGVLLGEALHHKVVSPSWMHGNNVMSYLTWVISTIIGTLLGSTIPNPEMFGLDFALVAMFIGLFVFQLFGMLSDEKRLIVYVLASVGLSYFLLATFLSGALSVLLATVVGCSVGVVLDDK
>NZ_CP021868.1|WP_000610954.1|2002454_2002778_-|AzlD-domain-containing-protein
MINSTVFLAILLGFVVSWVPRVAPFIFVKYKGLPNSLVKFLKFLPLSILFALTFSSFFSVKLGQLPTLKWLDLLAGIPTLVVTIRYRNLFYTVLTGLVTMALLRLLF
>NZ_CP021868.1|WP_000497678.1|2019463_2019637_-|preprotein-translocase-subunit-SecE
MFVKGIFQVLRDTTWPNRKQRWKDFISILEYTVFFTIVIYIFDKLLAAGVMDLINRF
>NZ_CP021868.1|WP_000057521.1|2019672_2019825_-|50S-ribosomal-protein-L33
MAQKKASLACTECGSRNYSIGVSSTPKPTRLEVNKFCKYCKKYTIHKETR
>NZ_CP021868.1|WP_000764803.1|2019873_2022195_-|penicillin-binding-protein
MKLFDKFIDLFRVDEDNDEMTRKNEQETREETSNLDGEEVYDIDDITRPSKSQYQRGIRHQKENAKSRPEWLQKVDRYLPSPKNPIRRFWRRYRIGKLLFIALMAFILIFGSYLFYLSKTATVSDLQSALKTTTTIYDKNKEYAGKLSGQKGTYVELNAISDHLKNAVIATEDRTFYENNGVNFKRFFLAVATLGKFGGGSTITQQLAKNAYLSQDQTIKRKAREFFLALELTKKYSKAEILTMYLNNSYFGNGVWGVEDASRKYFGTSAANLTVDEAATLAGMLKGPEVYNPYYSVENATNRRDTVLAAMVDAGKLTKSQAKEAASIGMKNRLADTYAGKINDYRYPSYFDAVVNEAIDTYGISEKDIVNNGYKIYTALDQNYQSGMQKTFDDTSLFPVSDYDGQSAQGASVALDPKTGGVRGLVGRVQSTKDAQFRSFNYATQSKRSPASTIKPLVVYSPAIASGWSIDKELPNKVQDFHGYKPSNYGGIETESIPMYQALANSYNIPAVYTLDKLGINKAFTYGRKFGLNMSSANKELGVALGGSVTTNPLEMAQAYSTFANDGIMHRAHLITRIETANGKLVKQFTDKPKRVISRSVASKMTSMMLGTFSNGTAINANVYGYTMAGKTGTTETDFNPNLSGDQWVVGYTPDVVISQWVGFKNTDKHHYLTDSSAGTASNIFSTQASYILPYTKGSSFTHIENAYFQNGIGSVYNAQDASNTTNQESRSIINDLKDSASKAAQDISRAVEDSNFQEKVKDAWNSLKDYFR
>NZ_CP021868.1|WP_000010476.1|2022238_2023123_+|RluA-family-pseudouridine-synthase
MSFSLKIRNPYGEHTVKELLEDYFLIPRKIRHFLRVKKHVLINNEFINWQTVVQENDTITLIFDDEDYPTKKIPLGRAELIDCLYEDEHLIIVNKPEGMKTHGNQPNEIALLNHVSAYSGQTCYVVHRLDMETSGAVLFAKNPFILPLINQRLERKEIWREYWALVEGKFSPKHQVLRDKIGRNRHDRRKRIIDSKNGQHAMTIIDVLKYIQNSSLIKCRLETGRTHQIRVHLSHHGHPLIGDPLYNPSSNNERLMLHAHRLTLSHPLTCETISVEAPSSTFEKILNNYKKGVG
>NZ_CP021868.1|WP_000459245.1|2023147_2024788_-|hypothetical-protein
MFDFFKKKVVKVCLVIFGIVLVSLLSLGFFYFSKGQVLSRFVAARSRTSGQAFDNIKEYMVWSDTGESITNDEANYANFEPLSKSEARKLGQEIKEGNKNDSMYLKRVGSRLGIFPDYRIANKPMSLTLKTNVPKLDVLLNQKKVATSNSDHFSVTVERLPRTHYTASLEGTSDGKEIKLKKDYDGKNQTIDLSVAFKSFTVTSNLMDGNLYFGDNRIAKLKDGSYSVENYPVTDGSKAYIKKVFNDGEITSHKQKLISIADNQTIKLDVDGLLNEKEAGQKLITAFNQLILYVSTGQDPQTLGTVFEKGGENDFYKGLKESIKAKFVTDNRKASHFTIPNIVLNKMTQVGKESYQVNFAADYDFNYDKSTDPDKKTYGHIIQNLTGNFIMKKSGNSYLISNDGKKDITVAKETNKVKADPVSIFPENLVGSWKGEVEDGTVTMTFDKDGKVTQKKVYKDSKSKESNHSAKVTKLEDKGNGLYLYQYESGTDTTTFVTGGIGGLKVKYAYGIKIEGNKIIPVIWQTSSDGEFDYHKPLLSKPLTKQ
>NZ_CP021868.1|WP_000077187.1|2024957_2026169_-|phosphopentomutase
MSQFDRIHLVVLDSVGIGAAPDANDFVNAGVPDGASDTLGHISKTVGLAVPNMAKIGLGNIPRPQALKTVPAEENPSGYATKLQEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEDIITKIEDFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLEELYRICEYARSITMERPALLGRIIARPYVGEPGNFTRTANRHDYAVSPFEDTVLNKLDQAGIDTYAVGKINDIFNGSGINHDMGHNKSNSHGIDTLIKTMGLSEFEKGFSFTNLVDFDALYGHRRDPHGYRDCLHEFDERLPEIISAMRDKDLLLITADHGNDPTYAGTDHTREYIPLLAYSPSFTGNGLIPVGHFADISATVADNFGVDTAMIGESFLQDLV
>NZ_CP021868.1|WP_000453154.1|2026235_2026907_-|deoxyribose-phosphate-aldolase
MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAAEYVSGKLAICTVIGFPNGYSTTAAKVFECQDAIKNGADEIDMVINLTDVKNGDFDTVEEEIRQIKAACQDHILKVIVETCQLTKEELIELCGVVTRSGADFIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAEKFIALGASRLGTSRIIKIVKNQKVEEGTY
>NZ_CP021868.1|WP_001159688.1|2026936_2028139_-|NupC/NupG-family-nucleoside-CNT-transporter
MQFIYSIIGILLVLGIVYAISFNRKSVSLSLIGKALIVQFIIALILVRIPLGQQVVSVVSTGVTKVINCGQAGLNFVFGSLADSGAKTGFIFAIQTLGNIVFLSALVSLLYYVGILGFVVKWIGKGVGKIMKSSEVESFVAVANMFLGQTDSPILVSKYLGRMTDSEIMVVLVSGMGSMSVSILGGYIALGIPMEYLLIASTMVPIGSILIAKILLPQTEPVQKIDDIKMDNKGNNANVIDAIAEGASTGAQMAFSIGASLIAFVGLVSLINMMLSGLGIRLEQIFSYVFAPFGFLMGFDHKNILLEGNLLGSKLILNEFVSFQQLGHLIKSLDYRTALVATISLCGFANLSSLGICVSGIAVLCPEKRGTLARLVFRAMIGGIAVSMLSAFIVGIVTLF
>NZ_CP021868.1|WP_001182060.1|2028159_2028939_-|uridine-phosphorylase
MQNYSGEVGLQYHLQIRPGDVGRYVIMPGDPKRCAKIAEHFDNAVLVADSREYVTYTGTLNGEKVSVTSTGIGGPSASIAMEELKLCGADTFIRVGTCGGIDLDVKGGDIVIATGAIRMEGTSKEYAPIEFPAVADLEVTNALVNAAKKLGYTSHAGVVQCKDAFYGQHEPERMPVSYELLNKWEAWKRLGTKASEMESAALFVAASHLGVRCGSDFLVVGNQERNALGMDNPMAHDTEAAIQVAVEALRTLIENDKSQ
>NZ_CP021868.1|WP_001125582.1|2029096_2029834_+|GntR-family-transcriptional-regulator
MPKNELNNKLNKLKHVQVYNKIFNMIQDGTYSPGMQLPSEPELAGQLNVSRATLRKSLALLQEDHLVKNIRGKGNFIRENSSNLSENGYENRQHPIKTCLTSKITEVELEFRVEVPAEAITASLKQETPVVVIADRWYHTDDGPLAYTLSFIPIELISDAEISLHDTKQLLNFIEEGIYQEGISSHSQSHLGYATSGNFSATKYTLSDHGQFILIQETIFNQEKILMCNKHYVPIEHFELSITSH

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_CP021868.1	1678421-1678450	1.0
NZ_CP021868_1	1.4\|976754\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976754-976783	30	NZ_CP021868.1	291756-291785	1.0
NZ_CP021868_3	3.1\|2017694\|30\|NZ_CP021868\|CRT	2017694-2017723	30	NZ_CP021868.1	2018078-2018107	1.0

1. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to position: 1678421-1678450, mismatch: 0, identity: 1.0

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
aagtccagtaggagaatctgaattatcatt	Protospacer
******************************

2. spacer 1.4|976754|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to position: 291756-291785, mismatch: 0, identity: 1.0

tctgcgggacggataacgttcaaattaggc	CRISPR spacer
tctgcgggacggataacgttcaaattaggc	Protospacer
******************************

3. spacer 3.1|2017694|30|NZ_CP021868|CRT matches to position: 2018078-2018107, mismatch: 0, identity: 1.0

ctctggcttaacgtctggtttaacttctgg	CRISPR spacer
ctctggcttaacgtctggtttaacttctgg	Protospacer
******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021868_1	1.7\|976952\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976952-976981	30	MK448932	Streptococcus phage Javan42, complete genome	5382-5411	0	1.0
NZ_CP021868_1	1.7\|976952\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976952-976981	30	MK448850	Streptococcus phage Javan132, complete genome	9929-9958	0	1.0
NZ_CP021868_1	1.7\|976952\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976952-976981	30	MK448742	Streptococcus phage Javan37, complete genome	7600-7629	0	1.0
NZ_CP021868_1	1.7\|976952\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976952-976981	30	MK448669	Streptococcus phage Javan11, complete genome	5382-5411	0	1.0
NZ_CP021868_1	1.9\|977084\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977084-977113	30	MK448824	Streptococcus phage Javan637, complete genome	5989-6018	0	1.0
NZ_CP021868_1	1.9\|977084\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977084-977113	30	MK449002	Streptococcus phage Javan642, complete genome	5989-6018	0	1.0
NZ_CP021868_1	1.9\|977084\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977084-977113	30	MK449003	Streptococcus phage Javan648, complete genome	5989-6018	0	1.0
NZ_CP021868_1	1.11\|977216\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977216-977245	30	MK448971	Streptococcus phage Javan52, complete genome	39082-39111	0	1.0
NZ_CP021868_1	1.11\|977216\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977216-977245	30	MK448829	Streptococcus phage Javan7, complete genome	33775-33804	0	1.0
NZ_CP021868_1	1.11\|977216\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977216-977245	30	MH853355	Streptococcus phage LF1, complete genome	24641-24670	0	1.0
NZ_CP021868_1	1.11\|977216\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977216-977245	30	MK448837	Streptococcus phage Javan10, complete genome	32310-32339	0	1.0
NZ_CP021868_1	1.11\|977216\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977216-977245	30	MH853358	Streptococcus phage LF4, complete genome	24641-24670	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	JX409894	Streptococcus phage LYGO9, complete genome	32870-32899	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448971	Streptococcus phage Javan52, complete genome	16521-16550	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448829	Streptococcus phage Javan7, complete genome	13428-13457	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448956	Streptococcus phage Javan48, complete genome	15492-15521	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MH853355	Streptococcus phage LF1, complete genome	4285-4314	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	JX409895	Streptococcus phage JX01, complete genome	1688-1717	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MH853356	Streptococcus phage LF2, partial genome	2505-2534	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MH853358	Streptococcus phage LF4, complete genome	4285-4314	0	1.0
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448837	Streptococcus phage Javan10, complete genome	11954-11983	1	0.967
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448742	Streptococcus phage Javan37, complete genome	13668-13697	1	0.967
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448851	Streptococcus phage Javan14, complete genome	15844-15873	1	0.967
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448763	Streptococcus phage Javan451, complete genome	11204-11233	2	0.933
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448736	Streptococcus phage Javan35, complete genome	13896-13925	2	0.933
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448781	Streptococcus phage Javan5, complete genome	15918-15947	2	0.933
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448938	Streptococcus phage Javan44, complete genome	13897-13926	2	0.933
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448911	Streptococcus phage Javan34, complete genome	13896-13925	2	0.933
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MK448916	Streptococcus phage Javan36, complete genome	13896-13925	2	0.933
NZ_CP021868_2	2.8\|1463143\|23\|NZ_CP021868\|CRT	1463143-1463165	23	NZ_CP029358	Azospirillum sp. CFH 70021 plasmid unnamed3	290710-290732	2	0.913
NZ_CP021868_1	1.9\|977084\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977084-977113	30	MK448854	Streptococcus phage Javan146, complete genome	6144-6173	4	0.867
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_CP022484	Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence	39260-39289	5	0.833
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NC_004669	Enterococcus faecalis V583 plasmid pTEF1, complete sequence	57906-57935	5	0.833
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_CP031029	Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-2, complete sequence	4832-4861	5	0.833
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_CP019513	Enterococcus faecalis strain CLB21560 plasmid pA, complete sequence	30829-30858	5	0.833
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_CP036247	Enterococcus faecalis R712 plasmid pR712_01, complete sequence	31585-31614	5	0.833
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_CP036248	Enterococcus faecalis R712 plasmid pR712_02, complete sequence	45080-45109	5	0.833
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	NZ_AP018540	Enterococcus faecalis strain KUB3006 plasmid pKUB3006-2, complete sequence	69635-69664	5	0.833
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	39397-39426	5	0.833
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	39886-39915	5	0.833
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	224847-224876	5	0.833
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	225336-225365	5	0.833
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	KJ019094	Synechococcus phage ACG-2014e isolate Syn7803US33, complete genome	122098-122127	6	0.8
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	KJ019156	Synechococcus phage ACG-2014e isolate Syn7803C2, complete genome	122189-122218	6	0.8
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	KJ019054	Synechococcus phage ACG-2014e isolate Syn7803C85, complete genome	122189-122218	6	0.8
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_AP019696	Absiella argi strain N6H1-5 plasmid pABar1, complete sequence	1576-1605	6	0.8
NZ_CP021868_1	1.1\|976556\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976556-976585	30	AP014501	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S32-C4, * SEQUENCING IN PROGRESS *, 3 ordered pieces	29134-29163	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_CP053930	Bacillus cereus strain FDAARGOS_797 plasmid unnamed1, complete sequence	92441-92470	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_CP013238	Clostridium butyricum strain CDC_51208 plasmid pNPD4_2, complete sequence	184587-184616	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_CP033789	Bacillus sp. FDAARGOS_527 plasmid unnamed2, complete sequence	209577-209606	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	AP014097	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C33A-MedDCM-OCT-S23-C1, * SEQUENCING IN PROGRESS *	41478-41507	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	AP014098	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C33A-MedDCM-OCT-S43-C2, * SEQUENCING IN PROGRESS *	40888-40917	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	MH133207	Acinetobacter phage vB_AbaM_B9, complete genome	36362-36391	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_CP009299	Bacillus cereus D17 plasmid unnamed, complete sequence	84958-84987	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	667631-667660	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_CP021438	Bacillus thuringiensis strain C15 plasmid pBMB172, complete sequence	167772-167801	7	0.767
NZ_CP021868_1	1.3\|976688\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976688-976717	30	NZ_CP012644	Rufibacter tibetensis strain 1351 plasmid 1, complete sequence	165008-165037	7	0.767
NZ_CP021868_1	1.5\|976820\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976820-976849	30	NC_022650	Escherichia coli JJ1886 plasmid pJJ1886_4, complete sequence	23480-23509	7	0.767
NZ_CP021868_1	1.5\|976820\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976820-976849	30	LC532225	Enterobacter hormaechei subsp. xiangfangensis A2483 plasmid pA2483imp-1 DNA, complete sequence	27398-27427	7	0.767
NZ_CP021868_1	1.5\|976820\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976820-976849	30	LC532227	Enterobacter hormaechei subsp. xiangfangensis A2504 plasmid pA2504imp-1 DNA, complete sequence	48484-48513	7	0.767
NZ_CP021868_1	1.5\|976820\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976820-976849	30	NZ_AP023201	Escherichia coli strain TUM18780 plasmid pMTY18780-4, complete sequence	26884-26913	7	0.767
NZ_CP021868_1	1.5\|976820\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976820-976849	30	NC_023907	Escherichia coli strain HS102707 plasmid pHS102707, complete sequence	29491-29520	7	0.767
NZ_CP021868_1	1.5\|976820\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976820-976849	30	MT774382	CrAssphage cr10_1, complete genome	26809-26838	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP038792	Escherichia coli strain PF9285 plasmid pDW54_1, complete sequence	52121-52150	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	MN693374	Marine virus AFVG_25M38, complete genome	19097-19126	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP044458	Acinetobacter indicus strain B18 plasmid pB18-3, complete sequence	38831-38860	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP006909	Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence	94545-94574	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	235573-235602	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NC_010379	Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence	70102-70131	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	190424-190453	7	0.767
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP039144	Acinetobacter sp. 10FS3-1 plasmid p10FS3-1-1, complete sequence	144145-144174	7	0.767
NZ_CP021868_3	3.1\|2017694\|30\|NZ_CP021868\|CRT	2017694-2017723	30	MN694011	Marine virus AFVG_250M697, complete genome	4834-4863	7	0.767
NZ_CP021868_3	3.1\|2017694\|30\|NZ_CP021868\|CRT	2017694-2017723	30	MN693760	Marine virus AFVG_250M698, complete genome	4833-4862	7	0.767
NZ_CP021868_3	3.5\|2017958\|30\|NZ_CP021868\|CRT	2017958-2017987	30	MN855875	Bacteriophage sp. isolate 328, complete genome	1396-1425	7	0.767
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	MK448891	Streptococcus phage Javan266, complete genome	20731-20760	7	0.767
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NC_013940	Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence	285150-285179	8	0.733
NZ_CP021868_1	1.7\|976952\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976952-976981	30	MN693626	Marine virus AFVG_250M1005, complete genome	16583-16612	8	0.733
NZ_CP021868_1	1.10\|977150\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977150-977179	30	MG592483	Vibrio phage 1.110.O._10N.261.52.C1, partial genome	36313-36342	8	0.733
NZ_CP021868_1	1.10\|977150\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977150-977179	30	NZ_CP015253	Bacillus thuringiensis Bt18247 plasmid p113275, complete sequence	98713-98742	8	0.733
NZ_CP021868_1	1.10\|977150\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977150-977179	30	MN693118	Marine virus AFVG_25M91, complete genome	55023-55052	8	0.733
NZ_CP021868_1	1.11\|977216\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977216-977245	30	MN698241	Pelagibacter phage HTVC027P, complete genome	28406-28435	8	0.733
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP009443	Francisella philomiragia strain O#319-036 [FSC 153] plasmid pFPJ_1, complete sequence	1906-1935	8	0.733
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NC_013092	Francisella philomiragia subsp. philomiragia ATCC 25017 plasmid pF243, complete sequence	971-1000	8	0.733
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	NZ_CP013966	Aeromonas hydrophila strain D4 plasmid pAhD4-1, complete sequence	62828-62857	8	0.733
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	KP942676	Pectobacterium carotovorum plasmid Drgb1, complete sequence	100824-100853	8	0.733
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	222231-222260	8	0.733
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	AB897757	Klebsiella phage K64-1 DNA, complete genome	221608-221637	8	0.733
NZ_CP021868_3	3.7\|2018042\|30\|NZ_CP021868\|CRT	2018042-2018071	30	NZ_CP026426	Acinetobacter sp. ACNIH1 plasmid pACI-df08, complete sequence	224631-224660	8	0.733
NZ_CP021868_1	1.8\|977018\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977018-977047	30	NC_021529	Vibrio phage nt-1, complete genome	214144-214173	9	0.7
NZ_CP021868_1	1.8\|977018\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977018-977047	30	MH622943	Myoviridae sp. isolate ctbc_4, complete genome	65086-65115	9	0.7
NZ_CP021868_1	1.9\|977084\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	977084-977113	30	NC_017076	Selenomonas ruminantium subsp. lactilytica TAM6421 plasmid pSRC2, complete sequence	37309-37338	9	0.7
NZ_CP021868_1	1.12\|977282\|30\|NZ_CP021868\|CRT	977282-977311	30	CP054320	Escherichia coli strain SCU-390 plasmid pSCU-390-2, complete sequence	490-519	9	0.7
NZ_CP021868_3	3.5\|2017958\|30\|NZ_CP021868\|CRT	2017958-2017987	30	NZ_CP054364	Escherichia coli strain SCU-171 plasmid pSCU-171-1, complete sequence	22761-22790	9	0.7
NZ_CP021868_3	3.5\|2017958\|30\|NZ_CP021868\|CRT	2017958-2017987	30	NZ_CP051689	Escherichia coli strain SCU-387 plasmid pSCU-387-1, complete sequence	31593-31622	9	0.7
NZ_CP021868_3	3.5\|2017958\|30\|NZ_CP021868\|CRT	2017958-2017987	30	NZ_CP012377	Escherichia coli strain GE3 isolate human faeces plasmid pGE3, complete sequence	16834-16863	9	0.7
NZ_CP021868_3	3.5\|2017958\|30\|NZ_CP021868\|CRT	2017958-2017987	30	NZ_CP040454	Escherichia coli strain UPEC132 plasmid unnamed1, complete sequence	16471-16500	9	0.7
NZ_CP021868_3	3.5\|2017958\|30\|NZ_CP021868\|CRT	2017958-2017987	30	MG711465	Faecalibacterium phage FP_Brigit, complete genome	26095-26124	9	0.7
NZ_CP021868_1	1.2\|976622\|30\|NZ_CP021868\|PILER-CR,CRISPRCasFinder,CRT	976622-976651	30	NZ_CP016845	Carnobacterium maltaromaticum strain TMW 2.1581 plasmid pL21581-1, complete sequence	49706-49735	10	0.667

1. spacer 1.7|976952|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448932 (Streptococcus phage Javan42, complete genome) position: , mismatch: 0, identity: 1.0

cactgaccacctctgaacaaccattcatca	CRISPR spacer
cactgaccacctctgaacaaccattcatca	Protospacer
******************************

2. spacer 1.7|976952|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448850 (Streptococcus phage Javan132, complete genome) position: , mismatch: 0, identity: 1.0

cactgaccacctctgaacaaccattcatca	CRISPR spacer
cactgaccacctctgaacaaccattcatca	Protospacer
******************************

3. spacer 1.7|976952|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448742 (Streptococcus phage Javan37, complete genome) position: , mismatch: 0, identity: 1.0

cactgaccacctctgaacaaccattcatca	CRISPR spacer
cactgaccacctctgaacaaccattcatca	Protospacer
******************************

4. spacer 1.7|976952|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448669 (Streptococcus phage Javan11, complete genome) position: , mismatch: 0, identity: 1.0

cactgaccacctctgaacaaccattcatca	CRISPR spacer
cactgaccacctctgaacaaccattcatca	Protospacer
******************************

5. spacer 1.9|977084|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448824 (Streptococcus phage Javan637, complete genome) position: , mismatch: 0, identity: 1.0

tgctccaaacgggcattttcagcttttagt	CRISPR spacer
tgctccaaacgggcattttcagcttttagt	Protospacer
******************************

6. spacer 1.9|977084|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK449002 (Streptococcus phage Javan642, complete genome) position: , mismatch: 0, identity: 1.0

tgctccaaacgggcattttcagcttttagt	CRISPR spacer
tgctccaaacgggcattttcagcttttagt	Protospacer
******************************

7. spacer 1.9|977084|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK449003 (Streptococcus phage Javan648, complete genome) position: , mismatch: 0, identity: 1.0

tgctccaaacgggcattttcagcttttagt	CRISPR spacer
tgctccaaacgggcattttcagcttttagt	Protospacer
******************************

8. spacer 1.11|977216|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 0, identity: 1.0

aaaaaattaatgacgcaattgctaagtcaa	CRISPR spacer
aaaaaattaatgacgcaattgctaagtcaa	Protospacer
******************************

9. spacer 1.11|977216|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 0, identity: 1.0

aaaaaattaatgacgcaattgctaagtcaa	CRISPR spacer
aaaaaattaatgacgcaattgctaagtcaa	Protospacer
******************************

10. spacer 1.11|977216|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 0, identity: 1.0

aaaaaattaatgacgcaattgctaagtcaa	CRISPR spacer
aaaaaattaatgacgcaattgctaagtcaa	Protospacer
******************************

11. spacer 1.11|977216|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 0, identity: 1.0

aaaaaattaatgacgcaattgctaagtcaa	CRISPR spacer
aaaaaattaatgacgcaattgctaagtcaa	Protospacer
******************************

12. spacer 1.11|977216|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 0, identity: 1.0

aaaaaattaatgacgcaattgctaagtcaa	CRISPR spacer
aaaaaattaatgacgcaattgctaagtcaa	Protospacer
******************************

13. spacer 1.12|977282|30|NZ_CP021868|CRT matches to JX409894 (Streptococcus phage LYGO9, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

14. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

15. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

16. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448956 (Streptococcus phage Javan48, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

17. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

18. spacer 1.12|977282|30|NZ_CP021868|CRT matches to JX409895 (Streptococcus phage JX01, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

19. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MH853356 (Streptococcus phage LF2, partial genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

20. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 0, identity: 1.0

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaatgt	Protospacer
******************************

21. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 1, identity: 0.967

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttacgaaaaaaatgt	Protospacer
******************.***********

22. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448742 (Streptococcus phage Javan37, complete genome) position: , mismatch: 1, identity: 0.967

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttacgaaaaaaatgt	Protospacer
******************.***********

23. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448851 (Streptococcus phage Javan14, complete genome) position: , mismatch: 1, identity: 0.967

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttacgaaaaaaatgt	Protospacer
******************.***********

24. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448763 (Streptococcus phage Javan451, complete genome) position: , mismatch: 2, identity: 0.933

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
acagactttagatttttatgaaaaaaagga	Protospacer
*************************** *

25. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448736 (Streptococcus phage Javan35, complete genome) position: , mismatch: 2, identity: 0.933

acagactttagatttttatgaaaaaaatgt-	CRISPR spacer
acagactttagatttttacg-aaaaaatgtc	Protospacer
******************.* *********

26. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448781 (Streptococcus phage Javan5, complete genome) position: , mismatch: 2, identity: 0.933

acagactttagatttttatgaaaaaaatgt-	CRISPR spacer
acagactttagatttttacg-aaaaaatgtc	Protospacer
******************.* *********

27. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448938 (Streptococcus phage Javan44, complete genome) position: , mismatch: 2, identity: 0.933

acagactttagatttttatgaaaaaaatgt-	CRISPR spacer
acagactttagatttttacg-aaaaaatgtc	Protospacer
******************.* *********

28. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448911 (Streptococcus phage Javan34, complete genome) position: , mismatch: 2, identity: 0.933

acagactttagatttttatgaaaaaaatgt-	CRISPR spacer
acagactttagatttttacg-aaaaaatgtc	Protospacer
******************.* *********

29. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MK448916 (Streptococcus phage Javan36, complete genome) position: , mismatch: 2, identity: 0.933

acagactttagatttttatgaaaaaaatgt-	CRISPR spacer
acagactttagatttttacg-aaaaaatgtc	Protospacer
******************.* *********

30. spacer 2.8|1463143|23|NZ_CP021868|CRT matches to NZ_CP029358 (Azospirillum sp. CFH 70021 plasmid unnamed3) position: , mismatch: 2, identity: 0.913

ggaagcactggtgctggctgacg	CRISPR spacer
ggaagcactggtgcgggctgccg	Protospacer
************** ***** **

31. spacer 1.9|977084|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MK448854 (Streptococcus phage Javan146, complete genome) position: , mismatch: 4, identity: 0.867

tgctccaaacgggcattttcagcttttagt	CRISPR spacer
tgctccaaacgagcattttctgcttttaag	Protospacer
***********.******** *******.

32. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022484 (Enterococcus faecalis ARO1/DG plasmid pARO1.1, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

33. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NC_004669 (Enterococcus faecalis V583 plasmid pTEF1, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

34. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031029 (Enterococcus faecalis strain TY1 isolate flatfish plasmid pDEF-2, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

35. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019513 (Enterococcus faecalis strain CLB21560 plasmid pA, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

36. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP036247 (Enterococcus faecalis R712 plasmid pR712_01, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

37. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP036248 (Enterococcus faecalis R712 plasmid pR712_02, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

38. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018540 (Enterococcus faecalis strain KUB3006 plasmid pKUB3006-2, complete sequence) position: , mismatch: 5, identity: 0.833

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
taaacctgtaggagaatctgtattatcatt	Protospacer
 *. ** ************* *********

39. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 5, identity: 0.833

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
aaccggtttaacttctggcttagcctctgc	Protospacer
  *.******.******************

40. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 5, identity: 0.833

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
aaccggtttaacttctggcttagcctctgc	Protospacer
  *.******.******************

41. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 5, identity: 0.833

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
aaccggtttaacttctggcttagcctctgc	Protospacer
  *.******.******************

42. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 5, identity: 0.833

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
aaccggtttaacttctggcttagcctctgc	Protospacer
  *.******.******************

43. spacer 1.12|977282|30|NZ_CP021868|CRT matches to KJ019094 (Synechococcus phage ACG-2014e isolate Syn7803US33, complete genome) position: , mismatch: 6, identity: 0.8

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
tgagattgtagatttttatgaaaaaactct	Protospacer
  ***.* ****************** * *

44. spacer 1.12|977282|30|NZ_CP021868|CRT matches to KJ019156 (Synechococcus phage ACG-2014e isolate Syn7803C2, complete genome) position: , mismatch: 6, identity: 0.8

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
tgagattgtagatttttatgaaaaaactct	Protospacer
  ***.* ****************** * *

45. spacer 1.12|977282|30|NZ_CP021868|CRT matches to KJ019054 (Synechococcus phage ACG-2014e isolate Syn7803C85, complete genome) position: , mismatch: 6, identity: 0.8

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
tgagattgtagatttttatgaaaaaactct	Protospacer
  ***.* ****************** * *

46. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_AP019696 (Absiella argi strain N6H1-5 plasmid pABar1, complete sequence) position: , mismatch: 6, identity: 0.8

---acagactttagatttttatgaaaaaaatgt	CRISPR spacer
ttcacag---ttagatttttatgataaaaattg	Protospacer
   ****   ************** ******

47. spacer 1.1|976556|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to AP014501 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S32-C4, *** SEQUENCING IN PROGRESS ***, 3 ordered pieces) position: , mismatch: 7, identity: 0.767

aagtccagtaggagaatctgaattatcatt	CRISPR spacer
agcgttagaagcagaatctgaattatcatt	Protospacer
*.  ..** ** ******************

48. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053930 (Bacillus cereus strain FDAARGOS_797 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
tgaaaaattactttatactgataatgttgc	Protospacer
****************..***** * .* .

49. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013238 (Clostridium butyricum strain CDC_51208 plasmid pNPD4_2, complete sequence) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
atatatcttactatatgttgattctccttt	Protospacer
  * *  ***** ********* *******

50. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033789 (Bacillus sp. FDAARGOS_527 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
tgaaaaattactttatactgataatgttgc	Protospacer
****************..***** * .* .

51. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to AP014097 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C33A-MedDCM-OCT-S23-C1, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
tgaaaaattactttatgatgctattaatgg	Protospacer
***************** ** **.*  *

52. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to AP014098 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C33A-MedDCM-OCT-S43-C2, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
tgaaaaattactttatgatgctattaatgg	Protospacer
***************** ** **.*  *

53. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MH133207 (Acinetobacter phage vB_AbaM_B9, complete genome) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
agtgaaattactttctgttgatattccaat	Protospacer
 * .********** ********.***  *

54. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009299 (Bacillus cereus D17 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
tgaaaaattactttatactgataatgttgc	Protospacer
****************..***** * .* .

55. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
atatatcttactatatgttgattctccttt	Protospacer
  * *  ***** ********* *******

56. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021438 (Bacillus thuringiensis strain C15 plasmid pBMB172, complete sequence) position: , mismatch: 7, identity: 0.767

tgaaaaattactttatgttgatactccttt	CRISPR spacer
ggtatcattcctttttgttgatactccttc	Protospacer
 * *  *** **** **************.

57. spacer 1.3|976688|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012644 (Rufibacter tibetensis strain 1351 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.767

gatatggtggacaggttcagcaggtcatgt	CRISPR spacer
gatatggtggacaggttgaacagcatatac	Protospacer
***************** *.***  .**..

58. spacer 1.5|976820|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NC_022650 (Escherichia coli JJ1886 plasmid pJJ1886_4, complete sequence) position: , mismatch: 7, identity: 0.767

gatgagtctgattgaagcgttggaagtttt	CRISPR spacer
gccaagtctgatggaagcgttggaagatcc	Protospacer
* ..******** ************* *..

59. spacer 1.5|976820|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to LC532225 (Enterobacter hormaechei subsp. xiangfangensis A2483 plasmid pA2483imp-1 DNA, complete sequence) position: , mismatch: 7, identity: 0.767

gatgagtctgattgaagcgttggaagtttt	CRISPR spacer
gccaagtctgatggaagcgttggaagatcc	Protospacer
* ..******** ************* *..

60. spacer 1.5|976820|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to LC532227 (Enterobacter hormaechei subsp. xiangfangensis A2504 plasmid pA2504imp-1 DNA, complete sequence) position: , mismatch: 7, identity: 0.767

gatgagtctgattgaagcgttggaagtttt	CRISPR spacer
gccaagtctgatggaagcgttggaagatcc	Protospacer
* ..******** ************* *..

61. spacer 1.5|976820|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP023201 (Escherichia coli strain TUM18780 plasmid pMTY18780-4, complete sequence) position: , mismatch: 7, identity: 0.767

gatgagtctgattgaagcgttggaagtttt	CRISPR spacer
gccaagtctgatggaagcgttggaagatcc	Protospacer
* ..******** ************* *..

62. spacer 1.5|976820|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NC_023907 (Escherichia coli strain HS102707 plasmid pHS102707, complete sequence) position: , mismatch: 7, identity: 0.767

gatgagtctgattgaagcgttggaagtttt	CRISPR spacer
gccaagtctgatggaagcgttggaagatcc	Protospacer
* ..******** ************* *..

63. spacer 1.5|976820|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MT774382 (CrAssphage cr10_1, complete genome) position: , mismatch: 7, identity: 0.767

gatgagtctgattgaagcgttggaagtttt	CRISPR spacer
tatgagtctcattgtagcgttggagttcat	Protospacer
 ******** **** *********. *. *

64. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP038792 (Escherichia coli strain PF9285 plasmid pDW54_1, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
cgttaatttagattttcatcaaaaaaatgt	Protospacer
    * **********.** **********

65. spacer 1.12|977282|30|NZ_CP021868|CRT matches to MN693374 (Marine virus AFVG_25M38, complete genome) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
tctccttttaaaattttatgaaaaaaatgt	Protospacer
 *   .****.* *****************

66. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP044458 (Acinetobacter indicus strain B18 plasmid pB18-3, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
gtaagcgttagatttttaataaaaaaatgt	Protospacer
..*..* ***********  **********

67. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP006909 (Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
aatgtatatagatttttatgaaaataatga	Protospacer
*  *  * **************** ****

68. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
aatgtatatagatttttatgaaaataatga	Protospacer
*  *  * **************** ****

69. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NC_010379 (Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
aatgtatatagatttttatgaaaataatga	Protospacer
*  *  * **************** ****

70. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
aatgtatatagatttttatgaaaataatga	Protospacer
*  *  * **************** ****

71. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP039144 (Acinetobacter sp. 10FS3-1 plasmid p10FS3-1-1, complete sequence) position: , mismatch: 7, identity: 0.767

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
gtaagcgttagatttttaataaaaaaatgt	Protospacer
..*..* ***********  **********

72. spacer 3.1|2017694|30|NZ_CP021868|CRT matches to MN694011 (Marine virus AFVG_250M697, complete genome) position: , mismatch: 7, identity: 0.767

ctctggcttaacgtctggtttaacttctgg	CRISPR spacer
agtcggcttaacttctggttcaacttctgt	Protospacer
  ..******** *******.********

73. spacer 3.1|2017694|30|NZ_CP021868|CRT matches to MN693760 (Marine virus AFVG_250M698, complete genome) position: , mismatch: 7, identity: 0.767

ctctggcttaacgtctggtttaacttctgg	CRISPR spacer
agtcggcttaacttctggttcaacttctgt	Protospacer
  ..******** *******.********

74. spacer 3.5|2017958|30|NZ_CP021868|CRT matches to MN855875 (Bacteriophage sp. isolate 328, complete genome) position: , mismatch: 7, identity: 0.767

ttctggtt---tggcctctggcttaacgtctgg	CRISPR spacer
---cggctgagtggcctctggctcaacgtctgc	Protospacer
   .**.*   ************.********

75. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to MK448891 (Streptococcus phage Javan266, complete genome) position: , mismatch: 7, identity: 0.767

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
cgattttttagcttccggcttagcatctgc	Protospacer
*  *  *********.******** ****

76. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NC_013940 (Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence) position: , mismatch: 8, identity: 0.733

tgaaaaattactttatgttgatactccttt	CRISPR spacer
gaaaaaattactttatgttgttattattag	Protospacer
 .****************** **.* .*

77. spacer 1.7|976952|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MN693626 (Marine virus AFVG_250M1005, complete genome) position: , mismatch: 8, identity: 0.733

cactgaccacctctgaacaaccattcatca	CRISPR spacer
aactgaccacctctcaacgaccatcacgcg	Protospacer
 ************* ***.*****.   *.

78. spacer 1.10|977150|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MG592483 (Vibrio phage 1.110.O._10N.261.52.C1, partial genome) position: , mismatch: 8, identity: 0.733

tgaataaataagctacaaaagataggattg	CRISPR spacer
ctaataactaagctacaaaagatacgtgaa	Protospacer
. ***** **************** *   .

79. spacer 1.10|977150|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015253 (Bacillus thuringiensis Bt18247 plasmid p113275, complete sequence) position: , mismatch: 8, identity: 0.733

tgaataaataagctacaaaagataggattg	CRISPR spacer
gaaataaataagctataaatgatagtttaa	Protospacer
 .*************.*** *****  * .

80. spacer 1.10|977150|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MN693118 (Marine virus AFVG_25M91, complete genome) position: , mismatch: 8, identity: 0.733

tgaataaataagctacaaaagataggattg	CRISPR spacer
tttgtaaataagttacaaaagatagtttac	Protospacer
*  .********.************  *

81. spacer 1.11|977216|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MN698241 (Pelagibacter phage HTVC027P, complete genome) position: , mismatch: 8, identity: 0.733

aaaaaattaatgacgcaattgctaagtcaa	CRISPR spacer
gtattggtaatgacccaattgctaagttaa	Protospacer
. *  . ******* ************.**

82. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP009443 (Francisella philomiragia strain O#319-036 [FSC 153] plasmid pFPJ_1, complete sequence) position: , mismatch: 8, identity: 0.733

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
gtgaattttagatttttaagaaacaaatga	Protospacer
....*.************ **** *****

83. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NC_013092 (Francisella philomiragia subsp. philomiragia ATCC 25017 plasmid pF243, complete sequence) position: , mismatch: 8, identity: 0.733

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
gtgaattttagatttttaagaaacaaatga	Protospacer
....*.************ **** *****

84. spacer 1.12|977282|30|NZ_CP021868|CRT matches to NZ_CP013966 (Aeromonas hydrophila strain D4 plasmid pAhD4-1, complete sequence) position: , mismatch: 8, identity: 0.733

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
ctatggtttggatttttatgaacaaaatgg	Protospacer
 .* . ***.************ ******

85. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to KP942676 (Pectobacterium carotovorum plasmid Drgb1, complete sequence) position: , mismatch: 8, identity: 0.733

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
ctctggtttatcttctggctttaaaaaggg	Protospacer
********** ********** .     **

86. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 8, identity: 0.733

ctctggtttagcttctggcttagcctctgg-----	CRISPR spacer
ttctggtttagcttctgggtta-----tgaatttt	Protospacer
.***************** ***     **.

87. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to AB897757 (Klebsiella phage K64-1 DNA, complete genome) position: , mismatch: 8, identity: 0.733

ctctggtttagcttctggcttagcctctgg-----	CRISPR spacer
ttctggtttagcttctgggtta-----tgaatttt	Protospacer
.***************** ***     **.

88. spacer 3.7|2018042|30|NZ_CP021868|CRT matches to NZ_CP026426 (Acinetobacter sp. ACNIH1 plasmid pACI-df08, complete sequence) position: , mismatch: 8, identity: 0.733

ctctggtttagcttctggcttagcctctgg	CRISPR spacer
agatggtttagcttctagcttagcaaccag	Protospacer
   *************.*******  *..*

89. spacer 1.8|977018|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NC_021529 (Vibrio phage nt-1, complete genome) position: , mismatch: 9, identity: 0.7

aattctgctttgaaatcaagttccatttct	CRISPR spacer
aattctgcgttgaaatcaagtgtaagaaac	Protospacer
******** ************ . *    .

90. spacer 1.8|977018|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to MH622943 (Myoviridae sp. isolate ctbc_4, complete genome) position: , mismatch: 9, identity: 0.7

aattctgctttgaaatcaagttccatttct	CRISPR spacer
tgccactctttgaaatcagcttccatttct	Protospacer
 ... . ***********. **********

91. spacer 1.9|977084|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NC_017076 (Selenomonas ruminantium subsp. lactilytica TAM6421 plasmid pSRC2, complete sequence) position: , mismatch: 9, identity: 0.7

tgctccaaacgggcattttcagcttttagt	CRISPR spacer
cactacaaacgggcattttcagccatgcac	Protospacer
..** ******************. *  ..

92. spacer 1.12|977282|30|NZ_CP021868|CRT matches to CP054320 (Escherichia coli strain SCU-390 plasmid pSCU-390-2, complete sequence) position: , mismatch: 9, identity: 0.7

acagactttagatttttatgaaaaaaatgt	CRISPR spacer
tcttgtcggagatttttatgaaaaaaaagt	Protospacer
 *  ...  ****************** **

93. spacer 3.5|2017958|30|NZ_CP021868|CRT matches to NZ_CP054364 (Escherichia coli strain SCU-171 plasmid pSCU-171-1, complete sequence) position: , mismatch: 9, identity: 0.7

ttctggtttggcctctggcttaacgtctgg	CRISPR spacer
ttctggtttggccgctggcgtaaaaatcct	Protospacer
************* ***** *** . ..

94. spacer 3.5|2017958|30|NZ_CP021868|CRT matches to NZ_CP051689 (Escherichia coli strain SCU-387 plasmid pSCU-387-1, complete sequence) position: , mismatch: 9, identity: 0.7

ttctggtttggcctctggcttaacgtctgg	CRISPR spacer
ttctggtttggccgctggcgtaaaaatcct	Protospacer
************* ***** *** . ..

95. spacer 3.5|2017958|30|NZ_CP021868|CRT matches to NZ_CP012377 (Escherichia coli strain GE3 isolate human faeces plasmid pGE3, complete sequence) position: , mismatch: 9, identity: 0.7

ttctggtttggcctctggcttaacgtctgg	CRISPR spacer
ttctggtttggccgctggcgtaaaaatcct	Protospacer
************* ***** *** . ..

96. spacer 3.5|2017958|30|NZ_CP021868|CRT matches to NZ_CP040454 (Escherichia coli strain UPEC132 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.7

ttctggtttggcctctggcttaacgtctgg	CRISPR spacer
ttctggtttggccgctggcgtaaaaatcct	Protospacer
************* ***** *** . ..

97. spacer 3.5|2017958|30|NZ_CP021868|CRT matches to MG711465 (Faecalibacterium phage FP_Brigit, complete genome) position: , mismatch: 9, identity: 0.7

ttctggtttggcctctggcttaacgtctgg	CRISPR spacer
gaagggtttggcctctggcttatcgctgcg	Protospacer
    ****************** **..  *

98. spacer 1.2|976622|30|NZ_CP021868|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016845 (Carnobacterium maltaromaticum strain TMW 2.1581 plasmid pL21581-1, complete sequence) position: , mismatch: 10, identity: 0.667

tgaaaaattactttatgttgatactccttt	CRISPR spacer
agaaaaattactttatcttgatttattaga	Protospacer
 *************** ***** . ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

17154 : 29219

Synechococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001042250.1\|17154_20880_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	1.9e-38	25.9
WP_000220676.1\|21113_22568_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.7e-54	32.7
WP_001291328.1\|22595_23618_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	1.1e-63	42.7
WP_000685109.1\|23785_24334_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.4e-25	35.6
WP_000780022.1\|24356_25109_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000166549.1\|25128_26676_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	3.9e-78	49.2
WP_001045908.1\|26868_27768_+	peptidoglycan DD-metalloendopeptidase family protein	A0A221J6U0	Arthrobacter_phage	4.1e-19	45.9
WP_000783419.1\|27914_29219_+	LysM peptidoglycan-binding domain-containing protein	A0A2D1GNZ3	Streptomyces_phage	3.7e-05	40.5

DBSCAN-SWA_2

611129 : 706300

Streptococcus_phage(87.76%)

protease,portal,head,terminase,capsid,transposase,tail,holin,integrase

attL 603417:603431|attR 624816:624830

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
603417:603431	attL	NA	NA	NA	NA
WP_000595708.1\|611129_612326_+	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	4.6e-103	54.5
WP_001068667.1\|612905_613253_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_071659971.1\|613397_614012_-\|integrase	site-specific integrase	F8HGP4	Streptococcus_phage	9.2e-55	60.7
WP_001872365.1\|614014_614281_-	hypothetical protein	Q77YW7	Streptococcus_phage	9.2e-20	65.2
WP_000640620.1\|614280_614685_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001122304.1\|614846_615047_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_001865698.1\|615068_615329_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	3.4e-11	43.0
WP_001867107.1\|615454_615664_+\|transposase	transposase	A0A0C5AEA5	Paenibacillus_phage	1.4e-15	55.4
WP_000508795.1\|615836_615998_-	NINE protein	NA	NA	NA	NA
WP_000594367.1\|616739_618017_+	ABC transporter permease	NA	NA	NA	NA
WP_000353149.1\|618026_618683_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.2e-22	31.8
WP_000594351.1\|618682_620059_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_000699093.1\|620155_620809_+	response regulator transcription factor	W8CYM9	Bacillus_phage	8.1e-25	33.6
WP_000076709.1\|622982_623162_+	CsbD family protein	J7KJ36	Streptococcus_phage	4.3e-21	96.4
WP_000027835.1\|623203_623392_+	hypothetical protein	J7KIW4	Streptococcus_phage	3.3e-16	78.2
WP_000078931.1\|623816_625022_+	rod shape-determining protein RodA	NA	NA	NA	NA
624816:624830	attR	NA	NA	NA	NA
WP_001106189.1\|625140_625701_+	HAD-IA family hydrolase	NA	NA	NA	NA
WP_000134196.1\|625701_627654_+	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	1.5e-143	44.8
WP_000094341.1\|627747_629472_+	septation ring formation regulator EzrA	NA	NA	NA	NA
WP_000589685.1\|629565_630207_+	phosphoserine phosphatase SerB	NA	NA	NA	NA
WP_000409124.1\|630227_630713_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_000137373.1\|630725_631181_-	YueI family protein	W6LLD2	Streptococcus_phage	7.8e-27	48.9
WP_000022829.1\|631378_632686_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	1.5e-235	95.4
WP_000823925.1\|632793_633858_-	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_000772014.1\|634086_635370_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_001127193.1\|635362_635875_+	shikimate kinase	NA	NA	NA	NA
WP_000089337.1\|635931_637305_+	LCP family protein	NA	NA	NA	NA
WP_000902654.1\|637405_638761_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	D0R096	Streptococcus_phage	1.8e-191	73.6
WP_001261523.1\|639282_639801_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_000445922.1\|640103_640634_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_151897929.1\|640803_646332_+	YPDG domain-containing protein	NA	NA	NA	NA
WP_000459853.1\|648101_649970_+	ImmA/IrrE family metallo-endopeptidase	E4ZFJ9	Streptococcus_phage	1.2e-302	80.9
WP_001122250.1\|650378_650948_+	hypothetical protein	A0A1B0RXB3	Streptococcus_phage	1.1e-86	81.0
WP_000905647.1\|650986_652942_-	DNA polymerase	D0R0B0	Streptococcus_phage	0.0e+00	83.6
WP_000464240.1\|652991_653156_-	hypothetical protein	NA	NA	NA	NA
WP_000208947.1\|653172_653736_-	DUF2815 family protein	A0A1B0RXA9	Streptococcus_phage	1.6e-90	92.8
WP_001898230.1\|653740_654862_-	DUF2800 domain-containing protein	A0A1X9I6D8	Streptococcus_phage	1.2e-198	88.5
WP_000041409.1\|654854_655178_-	hypothetical protein	A0A1B0RXB7	Streptococcus_phage	1.5e-32	71.2
WP_001208491.1\|658137_658419_+	VRR-NUC domain-containing protein	M1PFY8	Streptococcus_phage	2.0e-36	78.5
WP_000768924.1\|658399_659776_+	DEAD/DEAH box helicase	A0A1X9I6B0	Streptococcus_phage	3.9e-231	86.2
WP_000356300.1\|659768_660266_+	hypothetical protein	A0A1B0RXB9	Streptococcus_phage	4.3e-63	75.0
WP_000640709.1\|660664_661702_+	methionine adenosyltransferase	E4ZFL0	Streptococcus_phage	3.6e-168	84.6
WP_001138027.1\|661703_662069_+	HNH endonuclease	A0A1B0RXJ3	Streptococcus_phage	6.4e-64	90.1
WP_000999416.1\|662386_662842_+	hypothetical protein	A0A1B0RXC6	Streptococcus_phage	6.2e-48	56.2
WP_088181594.1\|662813_664070_+	DNA modification methylase	A0A1B0RXE5	Streptococcus_phage	3.4e-221	88.7
WP_001241132.1\|664066_665338_+	DNA cytosine methyltransferase	M1NSK8	Streptococcus_phage	1.3e-231	94.0
WP_000886223.1\|665402_665591_+	hypothetical protein	NA	NA	NA	NA
WP_000158644.1\|665661_665886_+	hypothetical protein	NA	NA	NA	NA
WP_000211844.1\|666000_666255_+	hypothetical protein	M1NSE3	Streptococcus_phage	3.9e-20	56.1
WP_000998225.1\|666256_666466_+	DUF4314 domain-containing protein	A0A1X9I6A3	Streptococcus_phage	1.3e-21	69.6
WP_001007669.1\|666514_666988_+\|terminase	phage terminase small subunit P27 family	A0A1X9I6K0	Streptococcus_phage	8.6e-85	97.5
WP_000220981.1\|666984_668577_+\|terminase	terminase large subunit	A0A1B0RXJ8	Streptococcus_phage	1.8e-307	95.7
WP_000024184.1\|668643_668937_+	hypothetical protein	NA	NA	NA	NA
WP_000181405.1\|668929_669268_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_000024081.1\|669351_669591_+	hypothetical protein	NA	NA	NA	NA
WP_000523687.1\|669652_670942_+\|portal	phage portal protein	A0A1B0RXD8	Streptococcus_phage	2.4e-230	91.1
WP_001225233.1\|670934_671633_+\|protease	Clp protease ClpP	A0A1B0RXE1	Streptococcus_phage	4.9e-105	83.2
WP_000040497.1\|671646_672855_+\|capsid	phage major capsid protein	M1Q1R5	Streptococcus_phage	8.9e-211	91.0
WP_000631138.1\|672851_673109_+\|head,tail	phage gp6-like head-tail connector protein	D0R0D7	Streptococcus_phage	8.6e-31	78.8
WP_000684960.1\|673108_673447_+\|head,tail	head-tail adaptor protein	A0A1B0RXJ6	Streptococcus_phage	4.3e-38	70.5
WP_000161631.1\|673439_673808_+	HK97 gp10 family phage protein	Q6DMT7	Streptococcus_phage	2.4e-34	61.3
WP_001209966.1\|673816_674143_+	hypothetical protein	M1Q1Z4	Streptococcus_phage	4.1e-38	68.5
WP_000818570.1\|674145_674715_+	hypothetical protein	A0A1B0RXE2	Streptococcus_phage	1.3e-98	95.2
WP_001249610.1\|674726_675146_+	hypothetical protein	A0A1X9I691	Streptococcus_phage	3.7e-55	75.5
WP_017827968.1\|675328_678448_+\|tail	phage tail tape measure protein	Q6DMT2	Streptococcus_phage	1.7e-245	77.2
WP_000618012.1\|678444_679170_+	hypothetical protein	Q6DMT1	Streptococcus_phage	9.4e-83	57.9
WP_000966165.1\|679169_682085_+\|tail	phage tail protein	Q6DMT0	Streptococcus_phage	0.0e+00	65.2
WP_000796416.1\|682097_683954_+	hypothetical protein	Q6DMS9	Streptococcus_phage	1.3e-258	73.8
WP_000661351.1\|683971_684376_+\|holin	phage holin family protein	D0R0E9	Streptococcus_phage	6.7e-46	74.8
WP_000515885.1\|684377_685847_+	N-acetylmuramoyl-L-alanine amidase	A0A1X9I678	Streptococcus_phage	6.9e-274	96.9
WP_000111881.1\|686070_687312_+	recombinase family protein	A0A1X9I6J1	Streptococcus_phage	1.5e-221	92.7
WP_191088066.1\|687214_688567_+	recombinase family protein	E4ZFN9	Streptococcus_phage	6.4e-250	94.4
WP_001025785.1\|688787_689261_+	VOC family protein	NA	NA	NA	NA
WP_017828018.1\|689313_689622_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000142741.1\|689714_690899_+	NADH-dependent flavin oxidoreductase	NA	NA	NA	NA
WP_001142755.1\|691150_691372_+	hypothetical protein	NA	NA	NA	NA
WP_000757296.1\|691489_692227_+	acid phosphatase AphA	NA	NA	NA	NA
WP_001267096.1\|692547_693066_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_000944932.1\|693902_694235_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_088181595.1\|694355_695500_-\|transposase	IS3-like element ISSag5 family transposase	Q8W6R2	Burkholderia_virus	2.4e-16	26.1
WP_162471060.1\|695632_695770_+	hypothetical protein	NA	NA	NA	NA
WP_000255857.1\|696698_697907_-	YSIRK-targeted surface antigen transcriptional regulator	NA	NA	NA	NA
WP_000777405.1\|698290_699964_+	SpaH/EbpB family LPXTG-anchored major pilin	NA	NA	NA	NA
WP_000815039.1\|700052_700976_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_000529914.1\|700977_701895_+	class C sortase SrtC1	NA	NA	NA	NA
WP_000746885.1\|701851_702703_+	class C sortase SrtC2	NA	NA	NA	NA
WP_088181632.1\|702784_705457_+	VWA domain-containing protein	NA	NA	NA	NA
WP_088181596.1\|705494_706300_-\|transposase	IS5 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

1565704 : 1571476

Streptococcus_phage(83.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000425856.1\|1565704_1566574_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	4.9e-110	70.4
WP_000358198.1\|1566573_1566900_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.2e-30	61.1
WP_000364565.1\|1566929_1567793_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	7.3e-74	49.7
WP_000715592.1\|1567812_1568448_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.8e-67	61.1
WP_000160532.1\|1568656_1569823_+\|transposase	IS30-like element ISSag9 family transposase	NA	NA	NA	NA
WP_001144248.1\|1570087_1570747_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	5.2e-64	55.6
WP_000178146.1\|1570765_1571476_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-18	28.5

DBSCAN-SWA_4

2092946 : 2102438

Streptococcus_phage(81.82%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000038826.1\|2092946_2093324_-	DUF1492 domain-containing protein	Q7Y4J3	Streptococcus_phage	3.2e-10	37.9
WP_000891152.1\|2093457_2093946_-	hypothetical protein	A0A1X9I5V2	Streptococcus_phage	3.5e-49	59.3
WP_001258764.1\|2094018_2094576_-	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	2.7e-29	58.9
WP_000694573.1\|2094733_2094907_-	hypothetical protein	A0A1X9I5U0	Streptococcus_phage	4.3e-10	56.1
WP_001069293.1\|2094903_2095161_-	hypothetical protein	NA	NA	NA	NA
WP_000656430.1\|2095453_2096848_-	hypothetical protein	W8CQP1	Croceibacter_phage	3.7e-43	33.7
WP_001029296.1\|2096859_2097717_-	primase C-terminal domain-containing protein	A0A1X9I6L2	Streptococcus_phage	3.0e-120	72.9
WP_001100460.1\|2097717_2097990_-	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	1.8e-18	56.8
WP_001157003.1\|2098330_2098522_-	hypothetical protein	NA	NA	NA	NA
WP_001256559.1\|2098524_2098746_-	hypothetical protein	NA	NA	NA	NA
WP_000877499.1\|2098742_2099075_-	hypothetical protein	NA	NA	NA	NA
WP_001259478.1\|2099151_2099658_-	hypothetical protein	A0A1X9I5V7	Streptococcus_phage	4.5e-07	35.4
WP_000130289.1\|2099746_2099920_-	hypothetical protein	NA	NA	NA	NA
WP_001021393.1\|2100018_2100657_-	Bro-N domain-containing protein	NA	NA	NA	NA
WP_001258609.1\|2100892_2101495_-	phage repressor protein	A0A1W6JPC3	Staphylococcus_phage	6.7e-42	46.7
WP_000909285.1\|2101510_2101696_-	hypothetical protein	A0A1X9I5U7	Streptococcus_phage	6.2e-07	54.8
WP_001080836.1\|2101850_2102438_+	helix-turn-helix domain-containing protein	A0A1X9I5U6	Streptococcus_phage	4.0e-15	37.5

DBSCAN-SWA_5

2117072 : 2124246

Staphylococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001042665.1\|2117072_2117747_-	transglycosylase SLT domain-containing protein	Q4Z8Z7	Staphylococcus_phage	8.9e-27	54.3
WP_000029069.1\|2117852_2118392_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	1.3e-17	46.4
WP_000359358.1\|2118607_2119402_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000510606.1\|2119394_2120237_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	2.0e-15	28.5
WP_000181758.1\|2120212_2121052_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	3.5e-20	30.0
WP_000239225.1\|2121051_2121594_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_000217762.1\|2121716_2123000_-	insulinase family protein	A0A2H4UVM3	Bodo_saltans_virus	1.6e-05	23.6
WP_000706188.1\|2123001_2124246_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	3.7e-87	41.3

Anti-CRISPR protein detection

Acr_ID: NZ_CP021868.1|WP_000455476.1|215230_215557_+|replication-initiator-protein-A

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP021868.1|WP_000455476.1|215230_215557_+|replication-initiator-protein-A

215230_215557_+

108 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|63	0.6759259259259259	1	1.0

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021868

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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