CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021906	Staphylococcus aureus strain Seattle 1945 isolate G477 plasmid pG477, complete sequence	0 crisprs	csa3	0	0	3	0
NZ_CP021905	Staphylococcus aureus strain Seattle 1945 isolate G477 chromosome, complete genome	10 crisprs	cas3,DEDDh,DinG,csa3,WYL	7	0	10	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 7917

Staphylococcus_phage(66.67%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000378396.1\|1015_3196_-	cadmium-translocating P-type ATPase CadA	E4ZFI9	Streptococcus_phage	9.3e-251	63.7
WP_000159129.1\|3188_3554_-	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.9e-23	47.0
WP_000361065.1\|3791_4169_-	hypothetical protein	NA	NA	NA	NA
WP_001105942.1\|4263_4938_+\|transposase	IS6-like element ISSau6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.3e-113	88.4
WP_001035802.1\|4972_5185_-	hypothetical protein	NA	NA	NA	NA
WP_000120605.1\|5900_6215_+	As(III)-sensing metalloregulatory transcriptional repressor ArsR	A0A2H4PQT4	Staphylococcus_phage	4.7e-39	73.1
WP_000153630.1\|6214_7504_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	6.6e-188	81.4
WP_000358995.1\|7521_7917_+	thioredoxin-dependent arsenate reductase	A0A2H4PQT9	Staphylococcus_phage	8.5e-62	86.3

DBSCAN-SWA_2

10926 : 11553

Bacillus_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000593106.1\|10926_11553_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.1e-22	33.7

DBSCAN-SWA_3

22095 : 24982

Enterobacteria_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000690626.1\|22095_22671_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	2.9e-42	51.7
WP_000069452.1\|22936_24982_+	copper-translocating P-type ATPase CopB	A0A218MNH6	uncultured_virus	1.0e-70	31.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP021905

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021905_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_1

688765-688864

Orphan

Consensus_repeat	Method
AAGAGCCCCTAATTAATAAATTAAAAGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021905_1

>merge|NZ_CP021905|1|688765-688864|CRISPRCasFinder
AAGAGCCCCTAATTAATAAATTAAAAGGGGACTAAAGGAATACAGTTGATTGCTAATGCACCAACAGCAAAAGAGCCCCTAATTAATAAATTAAAAGGGG

>NZ_CP021905|1|1|688765-688864|CRISPRCasFinder
AAGAGCCCCTAATTAATAAATTAAAAGGGG	ACTAAAGGAATACAGTTGATTGCTAATGCACCAACAGCAA
AAGAGCCCCTAATTAATAAATTAAAAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_001090984.1\|684872_685232_+\|HTH-type-transcriptional-regulator-SarX	unknown	unknown	gnl\|CDD\|130944
NZ_CP021905.1\|WP_000638614.1\|694841_695384_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP021905.1\|WP_000733427.1\|693935_694325_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001129758.1\|682576_684727_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP021905.1\|WP_031873456.1\|688881_690102_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341024
NZ_CP021905.1\|WP_000120368.1\|678498_679506_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NZ_CP021905.1\|WP_000865619.1\|686963_687608_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|225188
NZ_CP021905.1\|WP_000842865.1\|692609_693299_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000532966.1\|685421_686138_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NZ_CP021905.1\|WP_020967614.1\|690808_692455_+\|IS1182-like-element-ISSau3-family-transposase	unknown	unknown	gnl\|CDD\|226192
NZ_CP021905.1\|WP_000820892.1\|695478_696045_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|224527
NZ_CP021905.1\|WP_000148821.1\|696046_696505_-\|YaiI/YqxD-family-protein	unknown	unknown	gnl\|CDD\|178882
NZ_CP021905.1\|WP_031788497.1\|686702_686819_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001259673.1\|693425_693869_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP021905.1\|WP_000545116.1\|694462_694762_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000158021.1\|690098_690566_+\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|225395
NZ_CP021905.1\|WP_000731642.1\|680092_680890_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP021905.1\|WP_000687413.1\|687725_688592_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP021905.1\|WP_000081597.1\|681250_681895_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223742
NZ_CP021905.1\|WP_000833480.1\|686137_686611_+\|cupin	unknown	unknown	gnl\|CDD\|226072

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_001090984.1\|684872_685232_+\|HTH-type-transcriptional-regulator-SarX	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	8.17439e-23
NZ_CP021905.1\|WP_000638614.1\|694841_695384_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.895e-28
NZ_CP021905.1\|WP_001129758.1\|682576_684727_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.96752e-20
NZ_CP021905.1\|WP_031873456.1\|688881_690102_+\|MFS-transporter	gnl\|CDD\|341024	cd17471, MFS_Set, Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters. This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.22415e-101
NZ_CP021905.1\|WP_000120368.1\|678498_679506_+\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	5.23541e-104
NZ_CP021905.1\|WP_000865619.1\|686963_687608_+\|DUF402-domain-containing-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	6.78593e-91
NZ_CP021905.1\|WP_000532966.1\|685421_686138_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	8.8628e-136
NZ_CP021905.1\|WP_020967614.1\|690808_692455_+\|IS1182-like-element-ISSau3-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.22931e-37
NZ_CP021905.1\|WP_000820892.1\|695478_696045_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	1.24037e-61
NZ_CP021905.1\|WP_001259673.1\|693425_693869_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	8.28382e-13
NZ_CP021905.1\|WP_000148821.1\|696046_696505_-\|YaiI/YqxD-family-protein	gnl\|CDD\|178882	PRK00124, PRK00124, YaiI/YqxD family protein.	4.39168e-77
NZ_CP021905.1\|WP_000158021.1\|690098_690566_+\|DUF456-domain-containing-protein	gnl\|CDD\|225395	COG2839, COG2839, Uncharacterized protein conserved in bacteria [Function unknown].	8.41098e-45
NZ_CP021905.1\|WP_000731642.1\|680092_680890_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.45836e-40
NZ_CP021905.1\|WP_000687413.1\|687725_688592_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.18267e-39
NZ_CP021905.1\|WP_000081597.1\|681250_681895_+\|hypothetical-protein	gnl\|CDD\|223742	COG0670, COG0670, Integral membrane protein, interacts with FtsH [General function prediction only].	2.53359e-32
NZ_CP021905.1\|WP_000833480.1\|686137_686611_+\|cupin	gnl\|CDD\|226072	COG3542, COG3542, Uncharacterized conserved protein [Function unknown].	9.47473e-74

>NZ_CP021905.1|WP_000687413.1|687725_688592_+|LysR-family-transcriptional-regulator
MKIEDYRLLITLDETKTLRKAAEILYISQPAVTQRLKAIENAFGVDIFIRTKKQLITTTEGTMIIEHARDMLKRERLFFDKMQAHIGEVNGTISIGCSSLIGQTLLPEVLSLYNAQFPNVEIQVQVGSTEQIKANHRDYHVMITRGNKVMNLANTHLFNDDHYFIFPKNRRDDVTKLPFIEFQADPIYINQIKQWYNDNLEQDYHATITVDQVATCKEMLISGVGVTILPEIMMKNISKEQFEFEKVEIDNEPLIRSTFMSYDPSMLQLPQVDSFVNLMTSFVEEPKA
>NZ_CP021905.1|WP_000865619.1|686963_687608_+|DUF402-domain-containing-protein
MKVKYIDKRHWRRLIDREYTEVKVNNNRFKGIIGLVTMKKVRDPLEVTVVGQNIIVADDNYKWLQILPEKKRYSITVMFDNKGNPLEYYFDINIKNITQKGNARTVDLCLDVLALPSGEYELVDEDDLMFALESEQITKKQFHEAYMIAHQIMAELENDFKGFQKKIMYCFNKINAKAQKIHQKPQNKTNFEKSKQIKPKQYNQTKNHQQQKKN
>NZ_CP021905.1|WP_031788497.1|686702_686819_+|hypothetical-protein
MLQLILMKIALNDFEKDKSVLFIFLKNHFYEEMCVLSN
>NZ_CP021905.1|WP_000833480.1|686137_686611_+|cupin
MKSAEQWIDELQLESHPEGGFYRETIREVLKDGRRAPFSSIYFLLTDDNISHFHRIDADEVWYYHAGDSLTIHMINPDGEYTTATLGTDIQNGDVLQYAVPKGTIFASSIEISNTYSLVGCMCQPAFEFKQFELFKQSELITQYPHLKSVIEKYALK
>NZ_CP021905.1|WP_000532966.1|685421_686138_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWNNIKEKKAQKDKNTSRIYAKFGKEIYVAAKSGEPNPESNQALRLVLERAKTYSVPNHIIEKAIDKAKGAGDENFDHLRYEGFGPSGSMLIVDALTNNVNRTASDVRAAFGKNGGNMGVSGSVAYMFDHVATFGIEGKSVDEILETLMEQDVDVNDVIDDNGLTIVYAEPDQFAVVQDALRAAGVEEFKVAEFEMLPQTDIELSEADQVTFEKLIDALEDLEDVQNVFHNVDLK
>NZ_CP021905.1|WP_001090984.1|684872_685232_+|HTH-type-transcriptional-regulator-SarX
MNTEKLETLLGFYKQYKALSEYIDKKYKLSLNDLAVLDLTMKHCKDEKVLMQSFLKTAMDELDLSRTKLLVSIRRLIEKERLSKVRSSKDERKIYIYLNDDDISKFNALFEDVEQFLNI
>NZ_CP021905.1|WP_001129758.1|682576_684727_+|helix-turn-helix-transcriptional-regulator
MAKSCLHILTNNEYATTRCQDGIVLFWPIDGEIELQKFRKSKIIEDDIYIINHLDVFSIKNNKKTIMLYLSSDWFAELGFTFFNYHYTAKLIKSSYNLKCLLLKLTYRYLDNQPLNDADVRKLQDIIKIIAKEASMDKKIAQNQYRYAYYGDLRDELEYIYQNVNQRLTLKSVADKLFVSKSNLSSQFHLLMGMGFKKYIDTLKIGKSIEILLTTDSTISNISEHLGFSSSSTYSKMFKSYMDITPNEYRNLSKFNKSIMLNPEPLVGGMAQEVKEVILNYIDHYKNHLTDVIHIDEDKFEIPKLFQTVIQINTYTEMKLVFLEGLFKTLLNKNSQVVFFIMPSILKSKNTMSEEEKFTIIKTIIESNLKIAFNINDIETTYYVEEAFMNVIRQLSPNEINHHNNYEVHFVFDLSLMEIRTIYRMILKLHNIMLNVKLGLNITCLFDKPSVFKSLVSQIKRLKFDSLIIDNANLSSPYLMGESDELLLKNILHFKNLKQVINELDIEQEKLIFLNVENHKLLNNKERDLSNSAPLIYKTLSALYHNFHGFGLNIFDNHQTFNAMHLYDKNGFKTTLGLILEKFIEYVSKPKYENSYYSIFDIENYYCLVIYDWRVIESETIMSNFEDSQVYINFKNNILNDKYLIVIETLDENSGNINHLISKELRDKYEWNPSLLSKIDNYLKPAIEIKEHNFSNNSLNINVTFNALYIIKIGKK
>NZ_CP021905.1|WP_000081597.1|681250_681895_+|hypothetical-protein
MSQNTNHSYYHQNQHAQAISKVWLYFMYYWIIFGIGCYLGQFLPLSWRQPLSFGLLIIILATLVFERARRFGLIISHIYAVVIGLLSYATFTTYLQNLGPDIFYKNIALAIFAFIAFGIIGYFFVGDASSIGKYLFVTLITLIIASLIGIFLQNPIFYTIITVVSLLLFLLYTLYDFNRLKRGDYSPREMGFNLFINLLNIIKDILYLANMFRR
>NZ_CP021905.1|WP_000731642.1|680092_680890_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNNLVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIANRYGVSVDQLMAANNLRGYLIMPNQTLQIPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSPISTYWSDAKYWAGNAANDGYQVNNTPSVGSIMQSTPGPYGHVAYVERVNGDGSILISEMNYTYGPYNMNYRTIPASEVSSYAFIH
>NZ_CP021905.1|WP_000120368.1|678498_679506_+|inorganic-phosphate-transporter
MSYIIIVTIAVVIFSLIFDFINGFHDTANAVATAVSTRALTPKTAILMAAVMNFIGALTFTGVAGTITKDIVDPFKLENGLVVVLAAILAAIIWNLATWFYGIPSSSSHALIGSIAGAAIASEGSFGVLHYQGFTKIIIVLIVSPIIAFCVGFLMYSIFKVIFKNANLTRANRNFRFFQIFTAALQSFSHGTNDAQKSMGIITLALIVANVQNDGSVEPQLWVKFACATAMGLGTAIGGWKIIKTVGGNIMKIRPANGAAADLSSALTIFVASSLHFPLSTTHVVSSSILGVGASNRAKGVKWSTAQRMIITWVITLPISALLAGLLFYILNLFF
>NZ_CP021905.1|WP_031873456.1|688881_690102_+|MFS-transporter
MDMFAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFNRKIIIILALLMGALGFSIYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESINVSRSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGGLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILPDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSAASIMLGMILIFFTKNQKITKEDVIST
>NZ_CP021905.1|WP_000158021.1|690098_690566_+|DUF456-domain-containing-protein
MTIVLWLLIIAAFMLAFVGLIKPIIPSVLVLWVGFLIYQFGFHNQHLSWVFYVSMALLTILILCADFLANKYFVNRFGGSKFGEYAALIGVVIGCFVLPPFGIIIIPFILVFIVELIQGYSFERAVKVSIGSIVAFLTSSIAQASLGHKSLKKQQ
>NZ_CP021905.1|WP_020967614.1|690808_692455_+|IS1182-like-element-ISSau3-family-transposase
MYKNYNMTQLTLPIETSVRIPQNDISRYVNEIVETIPDSEFDEFRHHRGATSYHPKMMLKIILYAYTQSVFSGRRIEKLLHDSIRMMWLAQNQTPSYKTINRFRVNPNTDALIESLFIQFHSQCLKQNLIDDSSIFIDGTKVEANANRYTFVWKKSIQNHESKLNENSKALYRDLVEEKIIPEIKEDGDSDLTIEEIDLIGSHLDKEIEDLNHSIQNEDCTQIRKQTRKKRTEIKKFKKKFDDYSERKSKYEEQKSILKDRNSFSKTDHDATFMRMKEDHMKNGQLKPGYNLQIATNSQFVLSYDLFQNPTDTRTLIPFLTMIQNTFGYLPEYIVADAGYGSEQNYMAIIDDFNKTPLITYGMFIKDKTRKFKSDIFNTQNWKYDELNDEFICPNNKRIGFKRYAYRNNRYGFKRDFKLYECDDCSACSLRQQCMKPNSKSNKKIMKNYNWEYFKAQINQKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIVARRAVYYQIHLKKADFYQIINRNQLFYIA
>NZ_CP021905.1|WP_000842865.1|692609_693299_-|hypothetical-protein
MKSTAQLTKENNVKSLRLSNTDREIFENYMTYMRSDFRVNPHDTELIINRILKQLLSAEQHGLLALDFFNHDPKAHAIKELKAMPNETFKNIFKYIYQHIVLLIGIVSFLKGFLGFFMEKSGSNLYFVSFPFSVVVGFFIVFLFIWFSFKTIQLQCFNNSNWIWIFTYLAIILLIVGFFYVFFIPQSLLAFGPYIQVSNWVFIIFSFIVMPIGLRIERNISKKHSHTFL
>NZ_CP021905.1|WP_001259673.1|693425_693869_+|GNAT-family-N-acetyltransferase
MRTLNKDEHNYIKQIANIHETLLSQAESNYKCTKLSIALRYEMICSRLEHTNDKIYIYENEGQLIAFIWGHFSNEKSMVNIELLYVEPQFRKLGIATQLKIALEKWAKTMNAKRISSTIHKSNLPMISLNKDLGYQVSHVKMYKDID
>NZ_CP021905.1|WP_000733427.1|693935_694325_+|hypothetical-protein
MKKLIISIMAIMLFLTGCGKSQEKATLEKDIDNLQKENKELKDKKEKLQQEKEKLADKQKDLEKEVKDLKPSKEDNKDDKKDEDKNKDKDKEASQDKQSKDQTKSSDKDNHKKPTSTDKDQKANDKHQS
>NZ_CP021905.1|WP_000545116.1|694462_694762_+|hypothetical-protein
MHEQDFRILEGQDITLPELGRELENITGRTIADSTGEIKRVIAHLPNFESDTDTFVATYRLNHQQDFIDATFTALKSDRARLKEVPVHVELISYISKSK
>NZ_CP021905.1|WP_000638614.1|694841_695384_+|GNAT-family-N-acetyltransferase
MIYCETERLILRDWHEDDLLPFQKMNANYDVRKYFPSLLSYRRSELDMRTMDAVIKDYGIGLFAVEDKESHQWIGFIGLNYIPETSDYPFKELPLYEIGWRLLPEFWGKGLATEGAKATLKLAEQHQIYDVYSFTAEANKASQRVMEKIGMTVYDHFELPNLSKYHLLKRQVRYYINLRK
>NZ_CP021905.1|WP_000820892.1|695478_696045_-|TIGR00730-family-Rossman-fold-protein
MKRIAVYCGASKGHDPSYVQKAYDLGKYFAEQGYELVFGAGSIGIMGAIQDGVLDHGGKAIGVMPKMLDEHEITSQRLTELILVDSMHERKNKMAELADAFVMAPGGAGSLEEFFEMYSWAQIGIHEKPIAIYNINGFFNPLQTMIDHMIEEGFIDPKYRALAPLCDTKESLIESILNFKPLGTRSYD
>NZ_CP021905.1|WP_000148821.1|696046_696505_-|YaiI/YqxD-family-protein
MTHIIIDGDACPVVDSIIDLTTETGIFVTIIRSFSHFSNQLYPPHVSTLYVDDGPDAVDYKIVQLSTKDDIVITQDYGLASLLVDKVLIVMHHNGKIYNSKNIQQLLDKRYMNAQIRKQGGRHKGPPPFTKQDQKVFEKSLLRVIHRIKELD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP021905_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_2

776497-776581

Unclear

Consensus_repeat	Method
CACCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP021905_2

>merge|NZ_CP021905|2|776497-776581|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTGCCTGTAGAA

>NZ_CP021905|2|2|776497-776581|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTTTGTTGGGGCCCA
CACCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000749385.1\|777089_777929_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP021905.1\|WP_000057557.1\|786985_788425_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP021905.1\|WP_001224791.1\|786492_786978_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP021905.1\|WP_000192947.1\|767553_768195_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NZ_CP021905.1\|WP_000958224.1\|784704_785637_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP021905.1\|WP_000229253.1\|779254_781240_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP021905.1\|WP_000460983.1\|764946_766017_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP021905.1\|WP_001791369.1\|774937_775036_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000506536.1\|772364_774896_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP021905.1\|WP_001057973.1\|770643_771318_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP021905.1\|WP_000370984.1\|769568_770651_+\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|226583
NZ_CP021905.1\|WP_000662688.1\|781247_784094_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP021905.1\|WP_000617735.1\|771378_771951_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NZ_CP021905.1\|WP_000686342.1\|768338_769205_+\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NZ_CP021905.1\|WP_000538141.1\|778102_778753_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NZ_CP021905.1\|WP_000134963.1\|788491_789427_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP021905.1\|WP_100214456.1\|775210_776321_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP021905.1\|WP_000508984.1\|785642_786485_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP021905.1\|WP_000258151.1\|766334_767390_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NZ_CP021905.1\|WP_000638419.1\|778749_778986_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000057557.1\|786985_788425_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	7.77476e-06
NZ_CP021905.1\|WP_001224791.1\|786492_786978_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	7.57447e-30
NZ_CP021905.1\|WP_000192947.1\|767553_768195_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	7.46066e-72
NZ_CP021905.1\|WP_000958224.1\|784704_785637_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NZ_CP021905.1\|WP_000749385.1\|777089_777929_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.29354e-42
NZ_CP021905.1\|WP_000229253.1\|779254_781240_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP021905.1\|WP_000506536.1\|772364_774896_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP021905.1\|WP_001057973.1\|770643_771318_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.20522e-50
NZ_CP021905.1\|WP_000370984.1\|769568_770651_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	1.30855e-179
NZ_CP021905.1\|WP_000662688.1\|781247_784094_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP021905.1\|WP_000617735.1\|771378_771951_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NZ_CP021905.1\|WP_000460983.1\|764946_766017_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.2404e-45
NZ_CP021905.1\|WP_000686342.1\|768338_769205_+\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	9.17692e-120
NZ_CP021905.1\|WP_000538141.1\|778102_778753_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NZ_CP021905.1\|WP_000134963.1\|788491_789427_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP021905.1\|WP_100214456.1\|775210_776321_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP021905.1\|WP_000508984.1\|785642_786485_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	6.12313e-120
NZ_CP021905.1\|WP_000258151.1\|766334_767390_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	2.69988e-87
NZ_CP021905.1\|WP_000638419.1\|778749_778986_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34

>NZ_CP021905.1|WP_100214456.1|775210_776321_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDGEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDMGPFIESYLRQTMSHD
>NZ_CP021905.1|WP_001791369.1|774937_775036_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSLKK
>NZ_CP021905.1|WP_000506536.1|772364_774896_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKSVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NZ_CP021905.1|WP_000617735.1|771378_771951_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NZ_CP021905.1|WP_001057973.1|770643_771318_+|ComF-family-protein
MNNCLSCGAKLYENITIYNLFKKPNRLCDRCKENWDNIKLDIKARRCSRCLKYLDQNEAYCLDCKFLSAHFNLMEQLYCQFQYDGLMKEMIHQYKFSKDYYLCELLAHLIEIPQTSYDYIVPIPSSPAHDLSRTFNPVEAVLKAKGIRFDKILKMSNRPKQSHLTKKERLADENPFIIDTELDLNGKEILLVDDIYTTGLTIHRAGCKLYAKNIRKFKVFAFAR
>NZ_CP021905.1|WP_000370984.1|769568_770651_+|DEAD/DEAH-box-helicase
MDNVTRYKITESSQSSSQAYYHLSFELSEQQSYASEHIVRAIRMRQTILLYAVTGAGKTEMMFQGIQYARRQGDNIAIVSPRVDVVVEISKRIKDAFLNEDIDILHQQSSQQFEGHFVVCTVHQLYRFKQHFDTIFIDEVDAFPLSMDKSLQQALKSSSKVEHATIYMTATPPKQLLSEIPLENIIKLPARFHKKSLPVPKYRYFKLNNNKIQKMLYRILQDQINNQRYTLVFFNNIETMIKTFSIYKQKITKLTYVHSEDVFRFEKVEQLRNGQYDVIFTTTILERGFTMANLDVVVIDAHQYTQEALIQIAGRVGRKLECPTGKVLFFHEGVSMNMIQAKKEIQKMNKLALKRGWIDE
>NZ_CP021905.1|WP_000686342.1|768338_769205_+|DegV-family-protein
MKIAVMTDSTSYLSQDLIDKYNIQIAPLSVTFDDGKNFTESNEIAIEEFYNKMASSQTIPTTSQPAIGEWITKYEMLRDQGYTDIIVICLSSGISGSYQSSYQAGEMVEGVNVHAFDSKLAAMIEGCYVLRAIEMVEEGYEPQQIIDDLTNMREHTGAYLIVDDLKNLQKSGRITGAQAWVGTLLKMKPVLKFEDGKIIPEEKVRTKKRAIQTLEKKVLDIVKDFEEVTLFVINGDHFEDGQALYKKLQDDCPSAYQVAYSEFGPVVAAHLGSGGLGLGYVGRKIRLT
>NZ_CP021905.1|WP_000192947.1|767553_768195_-|YigZ-family-protein
MTQNIITVKKEHIIENVISKSRFIAHIKPVQNEDEAKAFIAAIKKEHKDATHNCSAYTIGPEMNIQKANDDGEPTGTAGVPMLDILKKLDVHNACVVVTRYFGGIKLGGGGLIRAYSGAVRDVIYDIGRVELREAVPCIVTLNYDQTGKFEYELASTHFMLRNQTYTDKVSYYIDVVKSDYEAFINFLNQMTAGNFDLTEETPKQLPFDIPTE
>NZ_CP021905.1|WP_000258151.1|766334_767390_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MVTLLLVAVTMIVSLTITPIVIAISKRLNLVDKPNFRKVHTKPISVMGGTVILFSFLIGIWIGHPIETEIKPLIIGAIIMYVLGLVDDIYDLKPYIKLAGQIAAALVVAFYGVTIDFISLPMGTTIHFGFLSIPITVIWIVAITNAINLIDGLDGLASGVSAIGLITIGFIAILQANIFITMICCVLLGSLIGFLFYNFHPAKIFLGDSGALMIGFIIGFLSLLGFKNITIIALFFPIVILAVPFIDTLFAMIRRVKKGQHIMQADKSHLHHKLLALGYTHRQTVLLIYSISILFSLSSIILYVSPPLGVVLMFVLIIFSIELIVEFTGLIDNNYRPILNLISRKSSHKEE
>NZ_CP021905.1|WP_000460983.1|764946_766017_-|GGDEF-domain-containing-protein
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYLIHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLKQNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSLVNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHKSGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFHLPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>NZ_CP021905.1|WP_000749385.1|777089_777929_+|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKTVKSPVRKASQAKKVVQQPVQQASKKVVVKQAPKQTVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NZ_CP021905.1|WP_000538141.1|778102_778753_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NZ_CP021905.1|WP_000638419.1|778749_778986_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NZ_CP021905.1|WP_000229253.1|779254_781240_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NZ_CP021905.1|WP_000662688.1|781247_784094_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNINLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENSDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NZ_CP021905.1|WP_000958224.1|784704_785637_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NZ_CP021905.1|WP_000508984.1|785642_786485_+|prolipoprotein-diacylglyceryl-transferase
MGGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPGEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTRKVK
>NZ_CP021905.1|WP_001224791.1|786492_786978_+|acetyltransferase
MRKFLSKEYHRTNPLWHVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQILNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP021905.1|WP_000057557.1|786985_788425_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMANQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLKEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP021905.1|WP_000134963.1|788491_789427_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA

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Crispr_ID: NZ_CP021905_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_3

834868-834947

Orphan

Consensus_repeat	Method
CCGTCAGCTTCTGTGTTGGGGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021905_3

>merge|NZ_CP021905|3|834868-834947|CRISPRCasFinder
CCGTCAGCTTCTGTGTTGGGGCCCACCCCAACTTGCATTGCTTGTAAGCTGACTTTCCGTCAGCTTCTATGTTGGGGCCC

>NZ_CP021905|3|3|834868-834947|CRISPRCasFinder
CCGTCAGCTTCTGTGTTGGGGCCC	ACCCCAACTTGCATTGCTTGTAAGCTGACTTT
CCGTCAGCTTCTATGTTGGGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_001183862.1\|839925_840777_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NZ_CP021905.1\|WP_000168845.1\|841104_841866_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP021905.1\|WP_000290491.1\|833177_833558_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NZ_CP021905.1\|WP_000150022.1\|830711_831428_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NZ_CP021905.1\|WP_000589549.1\|832663_833020_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NZ_CP021905.1\|WP_000807671.1\|843385_844627_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP021905.1\|WP_001018965.1\|835204_835591_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NZ_CP021905.1\|WP_001147955.1\|832199_832520_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP021905.1\|WP_000752917.1\|839497_839692_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_CP021905.1\|WP_000974455.1\|830141_830564_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP021905.1\|WP_000571208.1\|836129_837155_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NZ_CP021905.1\|WP_000255548.1\|828475_829093_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NZ_CP021905.1\|WP_000732338.1\|837860_838682_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP021905.1\|WP_016187137.1\|827842_828403_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP021905.1\|WP_001798062.1\|833735_834614_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NZ_CP021905.1\|WP_000569884.1\|829248_829743_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
NZ_CP021905.1\|WP_000520233.1\|837147_837843_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP021905.1\|WP_000205576.1\|841963_843271_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_CP021905.1\|WP_000422908.1\|831510_832050_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NZ_CP021905.1\|WP_001065804.1\|835583_835880_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_001183862.1\|839925_840777_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	1.10175e-76
NZ_CP021905.1\|WP_000168845.1\|841104_841866_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NZ_CP021905.1\|WP_000290491.1\|833177_833558_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	9.01516e-70
NZ_CP021905.1\|WP_000150022.1\|830711_831428_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	4.94416e-148
NZ_CP021905.1\|WP_000589549.1\|832663_833020_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NZ_CP021905.1\|WP_000807671.1\|843385_844627_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP021905.1\|WP_001018965.1\|835204_835591_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	1.24029e-35
NZ_CP021905.1\|WP_001147955.1\|832199_832520_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.63533e-24
NZ_CP021905.1\|WP_000752917.1\|839497_839692_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
NZ_CP021905.1\|WP_000974455.1\|830141_830564_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	1.40241e-61
NZ_CP021905.1\|WP_000571208.1\|836129_837155_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	1.27263e-168
NZ_CP021905.1\|WP_000255548.1\|828475_829093_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	1.86525e-61
NZ_CP021905.1\|WP_000732338.1\|837860_838682_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	5.3847e-113
NZ_CP021905.1\|WP_016187137.1\|827842_828403_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	2.24579e-44
NZ_CP021905.1\|WP_001798062.1\|833735_834614_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.81941e-75
NZ_CP021905.1\|WP_000569884.1\|829248_829743_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47
NZ_CP021905.1\|WP_000520233.1\|837147_837843_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	9.67625e-100
NZ_CP021905.1\|WP_000205576.1\|841963_843271_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	5.28886e-136
NZ_CP021905.1\|WP_000422908.1\|831510_832050_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.10032e-49
NZ_CP021905.1\|WP_001065804.1\|835583_835880_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.8621e-13

>NZ_CP021905.1|WP_001798062.1|833735_834614_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLNDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLKDIQAHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDDLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NZ_CP021905.1|WP_000290491.1|833177_833558_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQLEALLTAEKYSEMIGE
>NZ_CP021905.1|WP_000589549.1|832663_833020_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NZ_CP021905.1|WP_001147955.1|832199_832520_-|thioredoxin-family-protein
MQAIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NZ_CP021905.1|WP_000422908.1|831510_832050_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>NZ_CP021905.1|WP_000150022.1|830711_831428_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLYIEETLIQKINHRIDAIDVLELRIDQFENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVIISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
>NZ_CP021905.1|WP_000974455.1|830141_830564_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDPDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NZ_CP021905.1|WP_000569884.1|829248_829743_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NZ_CP021905.1|WP_000255548.1|828475_829093_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLLIIIAVVGVSIIIMSLPILQAIIYIVGLIFLMYMAWTIWHDKPSTDGEAQIMSPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NZ_CP021905.1|WP_016187137.1|827842_828403_+|histidine-phosphatase-family-protein
MRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGLFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEDRIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>NZ_CP021905.1|WP_001018965.1|835204_835591_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSNDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPFLPNINNERLVLVNE
>NZ_CP021905.1|WP_001065804.1|835583_835880_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIYGYTPTCGTCKVSERMLDITNEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFQSVTDLLENLK
>NZ_CP021905.1|WP_000571208.1|836129_837155_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIILITHEMHVIRCICDEVAVMESGKVIEHGPVTQVFENPQHAVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSIDFGKFEKELIERQVKMEVLRHG
>NZ_CP021905.1|WP_000520233.1|837147_837843_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NZ_CP021905.1|WP_000732338.1|837860_838682_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGSKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGNVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NZ_CP021905.1|WP_000752917.1|839497_839692_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NZ_CP021905.1|WP_001183862.1|839925_840777_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNSDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEVVKLNFAGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NZ_CP021905.1|WP_000168845.1|841104_841866_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NZ_CP021905.1|WP_000205576.1|841963_843271_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDENASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWVLGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NZ_CP021905.1|WP_000807671.1|843385_844627_+|cysteine-desulfurase
MAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPVQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSAIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDVDQLINALKQTKEFFSYEF

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Crispr_ID: NZ_CP021905_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_4

883990-884075

Orphan

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021905_4

>merge|NZ_CP021905|4|883990-884075|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACACAGAAGCTGGTGGAAAGCCAGCTTACAATAATGTGCAAGTTGG

>NZ_CP021905|4|4|883990-884075|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACACAGAAGCTGGTGG
AAAGCCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000167322.1\|881295_882486_+\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736
NZ_CP021905.1\|WP_001081626.1\|874709_875138_-\|Na(+)/H(+)-antiporter-subunit-B	unknown	unknown	gnl\|CDD\|183602
NZ_CP021905.1\|WP_000670755.1\|899137_900040_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP021905.1\|WP_000185311.1\|884233_885163_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NZ_CP021905.1\|WP_000660054.1\|886773_887979_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NZ_CP021905.1\|WP_000838046.1\|879860_880988_+\|NADH-dependent-flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|240086
NZ_CP021905.1\|WP_000758217.1\|890566_891091_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP021905.1\|WP_000054599.1\|875130_877536_-\|Na+/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237155
NZ_CP021905.1\|WP_000035058.1\|878113_878707_+\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|238908
NZ_CP021905.1\|WP_000066056.1\|885404_886784_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_CP021905.1\|WP_000007960.1\|889986_890562_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_CP021905.1\|WP_000138487.1\|882594_883839_+\|NAD-specific-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NZ_CP021905.1\|WP_000154943.1\|895318_898972_+\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
NZ_CP021905.1\|WP_000172356.1\|891841_895318_+\|helicase-exonuclease-AddAB-subunit-AddB	unknown	unknown	gnl\|CDD\|213736
NZ_CP021905.1\|WP_000711897.1\|891106_891682_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP021905.1\|WP_000148855.1\|888329_889661_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NZ_CP021905.1\|WP_011443624.1\|874368_874698_-\|Na(+)/H(+)-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|181497
NZ_CP021905.1\|WP_000781162.1\|877666_878050_-\|kinase	unknown	unknown	gnl\|CDD\|378054
NZ_CP021905.1\|WP_001067294.1\|879121_879499_+\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224023
NZ_CP021905.1\|WP_000573087.1\|872879_874376_-\|Na+/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|181085

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000167322.1\|881295_882486_+\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0
NZ_CP021905.1\|WP_001081626.1\|874709_875138_-\|Na(+)/H(+)-antiporter-subunit-B	gnl\|CDD\|183602	PRK12573, PRK12573, Na(+)/H(+) antiporter subunit B.	9.17513e-61
NZ_CP021905.1\|WP_000670755.1\|899137_900040_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.74159e-87
NZ_CP021905.1\|WP_000185311.1\|884233_885163_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	8.83368e-151
NZ_CP021905.1\|WP_000660054.1\|886773_887979_-\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NZ_CP021905.1\|WP_000838046.1\|879860_880988_+\|NADH-dependent-flavin-oxidoreductase	gnl\|CDD\|240086	cd04735, OYE_like_4_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NZ_CP021905.1\|WP_000758217.1\|890566_891091_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.75286e-49
NZ_CP021905.1\|WP_000054599.1\|875130_877536_-\|Na+/H+-antiporter-subunit-A	gnl\|CDD\|237155	PRK12645, PRK12645, monovalent cation/H+ antiporter subunit A; Reviewed.	0
NZ_CP021905.1\|WP_000035058.1\|878113_878707_+\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|238908	cd01927, cyclophilin_WD40, cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the protein is not known.	3.93388e-65
NZ_CP021905.1\|WP_000066056.1\|885404_886784_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP021905.1\|WP_000007960.1\|889986_890562_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	4.0006e-40
NZ_CP021905.1\|WP_000138487.1\|882594_883839_+\|NAD-specific-glutamate-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	0
NZ_CP021905.1\|WP_000154943.1\|895318_898972_+\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP021905.1\|WP_000172356.1\|891841_895318_+\|helicase-exonuclease-AddAB-subunit-AddB	gnl\|CDD\|213736	TIGR02773, ATP-dependent_helicase/deoxyribonuclease_subunit_B, helicase-exonuclease AddAB, AddB subunit. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP021905.1\|WP_000711897.1\|891106_891682_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.63465e-53
NZ_CP021905.1\|WP_000148855.1\|888329_889661_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NZ_CP021905.1\|WP_011443624.1\|874368_874698_-\|Na(+)/H(+)-antiporter-subunit-C	gnl\|CDD\|181497	PRK08600, PRK08600, putative monovalent cation/H+ antiporter subunit C; Reviewed.	3.20641e-61
NZ_CP021905.1\|WP_000781162.1\|877666_878050_-\|kinase	gnl\|CDD\|378054	pfam08810, KapB, Kinase associated protein B. This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	8.96507e-53
NZ_CP021905.1\|WP_001067294.1\|879121_879499_+\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|224023	COG1098, VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis].	3.22125e-44
NZ_CP021905.1\|WP_000573087.1\|872879_874376_-\|Na+/H+-antiporter-subunit-D	gnl\|CDD\|181085	PRK07691, PRK07691, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0

>NZ_CP021905.1|WP_000138487.1|882594_883839_+|NAD-specific-glutamate-dehydrogenase
MTENNNLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKFNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRKIDMRLAAYIIGIKRTAEAARYRGWA
>NZ_CP021905.1|WP_000167322.1|881295_882486_+|ornithine--oxo-acid-transaminase
MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINKNTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFATDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ
>NZ_CP021905.1|WP_000838046.1|879860_880988_+|NADH-dependent-flavin-oxidoreductase
MKSKYEPLFDKVVLPNGVELRNRFVLAPLTHISSNDDGTISDIELPYIEKRSQDVGITSNAASNVSDVGKAFPGQPSIAHDSDIEGLKRLATAMKKNGAKALVQIHHGGAQALPELTPDGDVVAPSPISLKSFGQKQEHSAREMTNEEIEQAIKDFGEATRRAIEAGFDGVEIHGANHYLIHQFVSPYYNRRNDVWANQYKFPIAVIEEVLKAKEVYGNKDFIVGYRLSPEEAESPGITMEITEELVNKISHMPIDYIHVSMMDTHATAREGKYAGQERLPLIHKWINGRMPLIGIGSIFTADDALDAVENVGVDLVAIGRELLLDYQFVEKIKDGREDEIINYFDPEREDNHHLTPNLWHQFNEGFYPLPRKDK
>NZ_CP021905.1|WP_001067294.1|879121_879499_+|S1-RNA-binding-domain-containing-protein
MNNYKIGQHIKVRVTGIQPYGAFVETPNHTEGLIHISEIMDDYVHNLKKFLSEGQIVKAKILSIDDEGKLNLSLKDNDYFKNYERKKEKQSVLDEIRETEKYGFQTLKERLPIWIKQSKRAIRND
>NZ_CP021905.1|WP_000035058.1|878113_878707_+|peptidyl-prolyl-cis-trans-isomerase
MANYPQLNKEVQQGEIKVVMHTNKGDMTFKLFPNIAPKTVENFVTHAKNGYYDGITFHRVINDFMIQGGDPTATGMGGESIYGGAFEDEFSLNAFNLYGALSMANSGPNTNGSQFFIVQMKEVPQNMLSQLADGGWPQPIVDAYGEKGGTPWLDQKHTVFGQIIDGETTLEDIANTKVGPQDKPLHDVVIESIDVEE
>NZ_CP021905.1|WP_000781162.1|877666_878050_-|kinase
MKLYRFSHKTGSYGVTIVEENGDDVLVKVEQVIKHPKQGDLHNPTETEGVFFHERKALSHFEKRYTKRSQLRDFNVDVLRYEDSLQQAITDLETKLKAQQTKHAEMSLASLARLKEDYSLQYKENFK
>NZ_CP021905.1|WP_000054599.1|875130_877536_-|Na+/H+-antiporter-subunit-A
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWIWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASKANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTVFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
>NZ_CP021905.1|WP_001081626.1|874709_875138_-|Na(+)/H(+)-antiporter-subunit-B
MNRQQNDLILQFAAVIIFFMVMVFGFSLFLAGHYTPGGGFVGGLLFASSLVIITIAFDIETMRKIFPLDFKILIGIGLVFCIATPIASWFLGKNFFTHVTFDIPLFILEPVHMTTAVFFDFGVLCAVVGTVMTIIISIGENE
>NZ_CP021905.1|WP_011443624.1|874368_874698_-|Na(+)/H(+)-antiporter-subunit-C
MIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
>NZ_CP021905.1|WP_000573087.1|872879_874376_-|Na+/H+-antiporter-subunit-D
MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPLRVELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLIGIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVAILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAPPIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANIKKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADLRQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSLVVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAGTETFYNPSTYVKAVLGGK
>NZ_CP021905.1|WP_000185311.1|884233_885163_-|glycerophosphodiester-phosphodiesterase
MTNSSKSFTKFMAASAVFTMGFLSVPTAGAEQTNHIANKPQAIQWHTNLTNERFTTIAHRGASGYAPEHTFQAYDKSHNELKASYIEIDLQRTKDGHLVAMHDENVNRTTNGHGKVEDYTLDELKQLDAGSWFNKKYPKYARASYKNAKVPTLDEILERYGPNANYYIETKSPDVYPGMEEQLLASLKKHHLLNKNKLKNGHVMIQSFSDESLKKIHRQNKHVPLVKLVDKGELQQFNDQRLKEIRSYAIGLGPDYTDLTEQNTHHLKDLGFIVHPYTVNEKADMLRLNKYGVDGVFTNFADKYKEVIK
>NZ_CP021905.1|WP_000066056.1|885404_886784_-|argininosuccinate-lyase
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLSTYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>NZ_CP021905.1|WP_000660054.1|886773_887979_-|argininosuccinate-synthase
MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMRAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
>NZ_CP021905.1|WP_000148855.1|888329_889661_+|glucose-6-phosphate-isomerase
MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
>NZ_CP021905.1|WP_000007960.1|889986_890562_+|TVP38/TMEM64-family-protein
MSFHQVEEWFEIFRQFGYLPGFILLYIRAIIPVFPLALYILINIQAYGPILGILISWLGLISGTFTVYLICKRLVDTERMQRIKQRTAVQRLISFIDRQGLIPLFILLCFPFTPNTLINFVASLSHIRPKYYFIVLASSKLVSTIILGYLGKEITTILTHPLRGILMLVVLIVFWIVGKKLEQHFMGSKKE
>NZ_CP021905.1|WP_000758217.1|890566_891091_+|signal-peptidase-I
MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKKLDGDIIPPNNFVVLNDHDNNQHDSRQFGLIDKKDIIGNISLRYYPFSKWTIQFKS
>NZ_CP021905.1|WP_000711897.1|891106_891682_+|signal-peptidase-I
MKKELLEWIISIAVAFVILFIVGKFIVTPYTIKGESMDPTLKDGERVAVNIIGYKTGGLEKGNVVVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQGDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDEDQIVGKVSFRFWPFSEFKYNFNPENTKN
>NZ_CP021905.1|WP_000172356.1|891841_895318_+|helicase-exonuclease-AddAB-subunit-AddB
MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLESFIADKNMQTRTKNKLEDIALIYRDFEQRIQNEFITGEDALQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEISNELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQINPMLRLLKTDVLTTSYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAATVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYLEQQANVELSPTSDILQMDEAFVCYVAMTRAKGNVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLDDEIVADSWLDAYQVIRDSDHLSQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWADIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
>NZ_CP021905.1|WP_000154943.1|895318_898972_+|helicase-exonuclease-AddAB-subunit-AddA
MTIPEKPQGVIWTDAQWQSIYETGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPTNWLDQLETPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDGVDKHLAVIEDERRLMGRVLEGGFIDISYLTGHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKSDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFHEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTLDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVRYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVFDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYKAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQIEDSSRPNVNISIIYFEDVSTETILDNDEYRSVNQLETMQNGNEDVKAQIKHQLDYQYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADTKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
>NZ_CP021905.1|WP_000670755.1|899137_900040_+|fumarylacetoacetate-hydrolase-family-protein
MKFLSFKYNDKTSYGVKVKREDAVWDLTQVFADFAEGDFHPKTLLAGLQQNHTLDFQEQVRKAVVAAEDSGKAEDYKISFNDIEFLPPVTPPNNVIAFGRNYKDHANELNHEVERLYVFTKAASSLTGDNATIPNHKDITDQLDYEGELGIVIGKSGEKIPKALALDYVYGYTIINDITDRKAQSEQDQAFLSKSLTGGCPMGPYIVTKDELPLPENVNIVTKVNNEIRQDGNTGEMILKIDELIEEISKYVALHPGDIIATGTPAGVGAGMQPPKFLQPGDEVKVTIDNIGTLTTYIAK

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Crispr_ID: NZ_CP021905_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_5

1942139-1942266

Orphan

Consensus_repeat	Method
AATTATGGAGCGGAAGATAGGATTTACACCTATACCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021905_5

>merge|NZ_CP021905|5|1942139-1942266|CRISPRCasFinder
AATTATGGAGCGGAAGATAGGATTTACACCTATACCTCATTCCAGGAAGGAATGTATTCTAAGAGTTGAAATACTCCCGCATTATTATTAAATTATGGAGCGGAAGATAGGATTTGCACCTATACCTC

>NZ_CP021905|5|5|1942139-1942266|CRISPRCasFinder
AATTATGGAGCGGAAGATAGGATTTACACCTATACCTC	ATTCCAGGAAGGAATGTATTCTAAGAGTTGAAATACTCCCGCATTATTATTA
AATTATGGAGCGGAAGATAGGATTTGCACCTATACCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000869463.1\|1950815_1951766_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240632
NZ_CP021905.1\|WP_000063551.1\|1940413_1941475_-\|PTS-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226167
NZ_CP021905.1\|WP_000110011.1\|1950272_1950719_-\|peroxide-responsive-transcriptional-repressor-PerR	unknown	unknown	gnl\|CDD\|223806
NZ_CP021905.1\|WP_000116227.1\|1932717_1934103_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP021905.1\|WP_000649898.1\|1938697_1940155_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP021905.1\|WP_000669380.1\|1931441_1932263_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP021905.1\|WP_001236371.1\|1953889_1954984_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP021905.1\|WP_001144055.1\|1937982_1938711_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP021905.1\|WP_000901019.1\|1934298_1934694_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000031108.1\|1935294_1935447_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001251219.1\|1935471_1936071_-\|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223440
NZ_CP021905.1\|WP_000251252.1\|1957201_1957744_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NZ_CP021905.1\|WP_000181394.1\|1936229_1936700_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	unknown	unknown	gnl\|CDD\|223297
NZ_CP021905.1\|WP_000597238.1\|1955174_1956911_-\|SAV1866-family-putative-multidrug-efflux-ABC-transporter	unknown	unknown	gnl\|CDD\|224055
NZ_CP021905.1\|WP_001011603.1\|1952307_1953597_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|183493
NZ_CP021905.1\|WP_000939529.1\|1951771_1952227_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP021905.1\|WP_001793998.1\|1936704_1937847_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
NZ_CP021905.1\|WP_000379091.1\|1959235_1960213_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|224899
NZ_CP021905.1\|WP_000284755.1\|1958046_1959084_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP021905.1\|WP_000886472.1\|1960473_1961310_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224596

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000869463.1\|1950815_1951766_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240632	cd12155, PGDH_1, Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family. Phosphoglycerate Dehydrogenase (PGDH) catalyzes the NAD-dependent conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first step in serine biosynthesis. Over-expression of PGDH has been implicated as supporting proliferation of certain breast cancers, while PGDH deficiency is linked to defects in mammalian central nervous system development. PGDH is a member of the 2-hydroxyacid dehydrogenase family, enzymes that catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	8.45391e-136
NZ_CP021905.1\|WP_000063551.1\|1940413_1941475_-\|PTS-transporter-subunit-IIC	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	1.65132e-122
NZ_CP021905.1\|WP_000110011.1\|1950272_1950719_-\|peroxide-responsive-transcriptional-repressor-PerR	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.09298e-56
NZ_CP021905.1\|WP_000116227.1\|1932717_1934103_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP021905.1\|WP_000649898.1\|1938697_1940155_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.55367e-98
NZ_CP021905.1\|WP_000669380.1\|1931441_1932263_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.57209e-78
NZ_CP021905.1\|WP_000379091.1\|1959235_1960213_+\|metal-dependent-hydrolase	gnl\|CDD\|224899	COG1988, COG1988, Predicted membrane-bound metal-dependent hydrolases [General function prediction only].	1.21408e-39
NZ_CP021905.1\|WP_001144055.1\|1937982_1938711_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.22702e-152
NZ_CP021905.1\|WP_001236371.1\|1953889_1954984_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	1.5476e-86
NZ_CP021905.1\|WP_001251219.1\|1935471_1936071_-\|glucosamine-6-phosphate-isomerase	gnl\|CDD\|223440	COG0363, NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism].	9.77274e-11
NZ_CP021905.1\|WP_000251252.1\|1957201_1957744_-\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	1.0244e-125
NZ_CP021905.1\|WP_000181394.1\|1936229_1936700_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	1.70324e-88
NZ_CP021905.1\|WP_000597238.1\|1955174_1956911_-\|SAV1866-family-putative-multidrug-efflux-ABC-transporter	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP021905.1\|WP_001011603.1\|1952307_1953597_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|183493	PRK12389, PRK12389, glutamate-1-semialdehyde aminotransferase; Provisional.	0
NZ_CP021905.1\|WP_000939529.1\|1951771_1952227_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.18155e-68
NZ_CP021905.1\|WP_001793998.1\|1936704_1937847_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	1.304e-179
NZ_CP021905.1\|WP_000284755.1\|1958046_1959084_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	4.67816e-157
NZ_CP021905.1\|WP_000886472.1\|1960473_1961310_-\|hypothetical-protein	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	0.000164936

>NZ_CP021905.1|WP_000063551.1|1940413_1941475_-|PTS-transporter-subunit-IIC
MSNAKNADNKQFFSKILNSIGAGVVIALVPNALLGEVLKIFKSGNEILELTYQLVILIQSFMAFIIGVLAAHQFKFNGAGAAIVGTSAMIGSGAVVYSNNSFMLKGIGDIINTSLVVIIACLIYMVLQNKLGSFELIILPVLVPIVSGGIGLITLPYIRKITQAIGNVIHSFTDLNPLLMSILISVAFSLLMVTPISLVAIATAISLNGLGSGAANLGIVAACVTFLFGSLRVNSIGVNAVLLIGAAKMMIPVYLKNLIISIPLTINGIITGIIAYVLQVKGTPLSAGFGYTGLVGPINAFNRMSGDPTMNIILLALGYFVIPFVSAFIVHELCKKFIPIYSNDIYKFEVPKQ
>NZ_CP021905.1|WP_000649898.1|1938697_1940155_-|ABC-transporter-permease-subunit
MKCLIRFILVLGLLISSAMVYINPAAYAEQDQKWEKIKERGELRVGLSADYAPMEFEHTVNGKTEYAGVDIDLAKKIAKDNNLKLKIVNMSFDSLLGALKTGKIDIIISGMTSTPERKKQVDFSDSYMMTKNIMLVKKDKVNDYKDIKDFNNKKVGAQKGTEQEKIAQTEIENASITSLSRLPDVILALKSGKVEGVVVEKPVAEAYLKQNPKLGISNVKFNEEEKDTVIAVPKDSPKLLSQINKTIKEVKDKGLIDKYMTNAANAMNDDSGFISKYGSFFLKGIKITILISLIGVALGSILGAFVALMKLSKIKIISWIASIYIEILRGTPMLVQVFIVFFGITAALGLDISALVCGTIALVINSSAYIAEIIRAGINAVDKGQMEAARSLGLNYRQTMKSVIMPQAIKNILPALGNEFVTLIKESSIVSTIGVGEIMFNAQVVQGISFDPFTPLLVAAALYFVLTFVLTRIMNMIEGRLNASD
>NZ_CP021905.1|WP_001144055.1|1937982_1938711_-|amino-acid-ABC-transporter-ATP-binding-protein
MPVIKINNLNKVFGDNEVLKDINLEINQGEVVAIIGPSGSGKSTLLRCMNLLEVPTKGQVIFEGNDLTEKGTQVDKLRQKMGMVFQNFNLFPHKKVVDNIILAPKLLKKDNNDELHKEALSLLDKVGLKEKADVYPNQLSGGQKQRVAIARALAMHPDVILFDEPTSALDPEVVGDVLKVMKDLAKEGMTMVVVTHEMGFAKDVSDKVIFMADGVVVESGTPVEIFEQPQHERTQNFLARVL
>NZ_CP021905.1|WP_001793998.1|1936704_1937847_-|tRNA-epoxyqueuosine(34)-reductase-QueG
MGGIRLDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIALRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDMLAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVSIPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGNRLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRGKKPIQRNAILALAHFNEVDAIPELKKVATTDERPMIRATAYWAIGQILGEEARDFINANYDQEDAEVQNEMIKGLDTRRE
>NZ_CP021905.1|WP_000181394.1|1936229_1936700_-|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL
MTNHIVLYQPEIPANTGNIARTCAGTNTHLHLIKPLGFRTDDKMLKRAGLDYWEFVNITYHDSIEAFFEATNGEYYLLTKFGKKTYSDFDFSNHDKDFYFIFGKETTGLPDWVKEKYQDTALRIPMSEHIRSLNLSNTAALLIYEALRQQDFPGLN
>NZ_CP021905.1|WP_001251219.1|1935471_1936071_-|glucosamine-6-phosphate-isomerase
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGVPAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGKTSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
>NZ_CP021905.1|WP_000031108.1|1935294_1935447_-|hypothetical-protein
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
>NZ_CP021905.1|WP_000901019.1|1934298_1934694_-|hypothetical-protein
MLGKYWIQLLIATVIISLISIKAFPLAIGALYLPIIFKVIKLQLNLSKGLIDDVNAQTFIKSNQSGIVISVICCLLITGILYYTLDGFYASLTGVLGTLVALNPYTTIVSAVLYILTAIATVEATKTKYRN
>NZ_CP021905.1|WP_000116227.1|1932717_1934103_-|class-II-fumarate-hydratase
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHHSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAQYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>NZ_CP021905.1|WP_000669380.1|1931441_1932263_+|RluA-family-pseudouridine-synthase
MKFKIPENFNDLSLRDIFQQLKVPKKDLHHLNMSKDITINDKPARLMDKVHTGDDVFVPTIDEKSNYVPSYRYAQIKYEDDDMAIVMKPKGVKTHPNDLKESNTLMNHVIYTVDSDYVEPIHRLDQETVGLLIVAKNPLMKKILDRMLEDNDITRIYKANVKALLPLKPQTIDMPIGKDKFHSNKRRVSPTGQRAITHILTSKMIKETVCQLEIKLDTGRTHQIRVHLAEIGHPVIGDPLYGDSTLRQLELESYKIEFVHPLTKEVISVSLDD
>NZ_CP021905.1|WP_000110011.1|1950272_1950719_-|peroxide-responsive-transcriptional-repressor-PerR
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
>NZ_CP021905.1|WP_000869463.1|1950815_1951766_-|2-hydroxyacid-dehydrogenase
MKVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLANLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIVINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEVLKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY
>NZ_CP021905.1|WP_000939529.1|1951771_1952227_-|thioredoxin-dependent-thiol-peroxidase
MLQKGEQFPIFKLENQDGTVITNDTLKGKKAIVYFYPRDNTPTCTTEACDFRDNLEMFNDLDVAVYGISGDSKKKHQNFIEKHGLNFDLLVDEDFKLAKETGVYQLKKSFGKESMGIVRTTFIIDEQGKVLDVIEKVKVKTQIEELKNILG
>NZ_CP021905.1|WP_001011603.1|1952307_1953597_+|glutamate-1-semialdehyde-2,1-aminomutase
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQEQAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHSNGTLVIYDEVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQDGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIKQTLKAADYAFSQMK
>NZ_CP021905.1|WP_001236371.1|1953889_1954984_+|aromatic-acid-exporter-family-protein
MRLGARIFKTGIAIILAMSIASLLPDDVGLKALAGVSAVVAMQPSIYRSFKTVSDQALGNIIGAILSVTMVTIFSDNFIIMGVTVIVLIAILFKFNLAHVATLASVTALIIMGQHTGSFYITAFYRFVLVMIGVISSSLVNFVFLPPKFETKIYYNSLNISSDIFMWFKLVLNDTTEFNNIKQDSHNLKQRVEKLEKIYDYYSEERPITKKHIHQQNRKKILFREVVQTTRQAYEVLNKLSRYQNDLYLLNNNFLLQIKLDLDSLTAFHEQILASLSKKARYNVTHVDYELDNPQKKDLLSTFQHELINHPYQTEYSFANVMQIVAAIEEYRHHLEHLDRIRISFFTYHRSDADIEIVEEDFDL
>NZ_CP021905.1|WP_000597238.1|1955174_1956911_-|SAV1866-family-putative-multidrug-efflux-ABC-transporter
MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHALTTDEKVHHLTIAIGIALFIFVIVRPPIEFIRQYLAQWTSNKILYDIRKKLYNHLQALSARFYANNQVGQVISRVINDVEQTKDFILTGLMNIWLDCITIIIALSIMFFLDVKLTLAALFIFPFYILTVYVFFGRLRKLTRERSQALAEVQGFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLTRALKHTRWNAYSFAAINTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVASFTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYNDNEAPILKDINLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILIDGHNIKDFLTGSLRNQIGLVQQDNILFSDTVKENILLGRPTATDEEVVEAAKMANAHDFIMNLPQGYDTEVGERGVKLSGGQKQRLSIARIFLNNPPILILDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTITHADKIVVIENGHIVETGTHRELIAKQGAYEHLYSIQNL
>NZ_CP021905.1|WP_000251252.1|1957201_1957744_-|DUF402-domain-containing-protein
MVRESIPKEGENIKIQSYKHDGKIHRVWSETTILKGTDHVVIGGNDHTLVTESDGRTWITREPAIVYFHSEYWFNVICMFREDGIYYYCNLSSPFVCDEEALKYIDYDLDIKVYPNGKYHLLDEDEYEQHMNQMNYPHDIDIILRRNVDILQQWIEQKKGPFAPDFIKVWKDRYKKIRQY
>NZ_CP021905.1|WP_000284755.1|1958046_1959084_-|A/G-specific-adenine-glycosylase
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFPTVEVLSQASEDEVLKYWEGLGYYSRARNFHTAIKEVHDKYEGLVPKDPDQFKALKGVGPYTQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQSTRKSYEQELLPYVTTEAGTFNQAMMELGALICTPKNPLCLFCPVQENCEAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNNQGQYLLQKRSEKLLHGMWQFPMFKSEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWKIKVYAVSGTINIERLPDDMIWFDLSDRDQYTFPVPMSKIYQFING
>NZ_CP021905.1|WP_000379091.1|1959235_1960213_+|metal-dependent-hydrolase
MDTATHIAIGVGLTALATQDPAMASTFGATATTLIVGSLIPDGDTVLKLKDNATYISHHRGITHSIPFTILWPILITFLIFTFFSGTHPFHVWMWAQLAVFLHVFVDIFNSYGTQALRPITNKWIQLSVINTFDPIIFTVLCIGIVLWVVGLHPLAVFFPIIALLIIYYMIRFKMRAVIKQQALKAIQQEHHPVKVFVAPTIKFMEWRVAIQTDAHDYVGKAYGRNVVFSDKVERQKLSTDSILWKVKGNKDIRTFLNFSSIYRWQTTTLADGSTEIRLIDLRYLKNDHYSFVAIAHVTKDNVIDHSYIGWVFTEDKLQRKLYAK
>NZ_CP021905.1|WP_000886472.1|1960473_1961310_-|hypothetical-protein
MLDNIILYFKNLPHTKRYVTERLKQSWKSFLIVLAACLILIIASETLFSFSHLTDVKEVRWLFRLIALIVFAVLMFTIYISYHHYMNDFLVTKLFNISAATPVVIMSILSFIMLVILTMISALVKPVNFETSYIALFYFIVMATIFVGLISVTFGLIRLLTEKINIIFYGICVLCFLVLPIIFIPNPNHVFINHILMLNPMYYIVNGIAQSIIFGISSMENIPYHFYFILFLCLIAAVNFVLARYTTHAIYNKTSKVTQTDNQQDVSKDSTDEADTSS

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Crispr_ID: NZ_CP021905_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_6

1976303-1976385

Orphan

Consensus_repeat	Method
TCTGTGTTGGGGCCCCGCCAACCTGCA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP021905_6

>merge|NZ_CP021905|6|1976303-1976385|CRISPRCasFinder
TCTGTGTTGGGGCCCCGCCAACCTGCACATTATCGTAAGCTGACTTTTTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTGCA

>NZ_CP021905|6|6|1976303-1976385|CRISPRCasFinder
TCTGTGTTGGGGCCCCGCCAACCTGCA	CATTATCGTAAGCTGACTTTTTGTCAGCT
TCTGTGTTGGGGCCCCGCCAACTTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000949466.1\|1981035_1981536_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NZ_CP021905.1\|WP_000149064.1\|1974051_1974753_-\|cell-wall-active-antibiotics-response-protein	unknown	unknown	gnl\|CDD\|227100
NZ_CP021905.1\|WP_000228670.1\|1970038_1970503_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_CP021905.1\|WP_000613738.1\|1981926_1982481_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NZ_CP021905.1\|WP_001110178.1\|1974767_1975154_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001793983.1\|1968432_1969689_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
NZ_CP021905.1\|WP_001017131.1\|1973011_1974055_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP021905.1\|WP_001791533.1\|1976389_1976563_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001790679.1\|1981617_1981710_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001250339.1\|1979430_1980744_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_CP021905.1\|WP_001643743.1\|1978059_1978473_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000153535.1\|1972392_1973022_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP021905.1\|WP_000037081.1\|1971062_1972280_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NZ_CP021905.1\|WP_001014423.1\|1976884_1977871_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP021905.1\|WP_000180460.1\|1969691_1969892_-\|DUF1128-family-protein	unknown	unknown	gnl\|CDD\|227177
NZ_CP021905.1\|WP_000544973.1\|1978697_1979429_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_CP021905.1\|WP_000636142.1\|1975370_1976129_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP021905.1\|WP_000428172.1\|1970509_1970785_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000140179.1\|1982547_1983618_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NZ_CP021905.1\|WP_001790257.1\|1978501_1978612_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000949466.1\|1981035_1981536_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	1.15329e-74
NZ_CP021905.1\|WP_000149064.1\|1974051_1974753_-\|cell-wall-active-antibiotics-response-protein	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	9.42019e-79
NZ_CP021905.1\|WP_000228670.1\|1970038_1970503_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	5.12846e-65
NZ_CP021905.1\|WP_000613738.1\|1981926_1982481_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
NZ_CP021905.1\|WP_001793983.1\|1968432_1969689_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	0
NZ_CP021905.1\|WP_001017131.1\|1973011_1974055_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.78722e-72
NZ_CP021905.1\|WP_001250339.1\|1979430_1980744_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.60835e-98
NZ_CP021905.1\|WP_000153535.1\|1972392_1973022_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.75115e-79
NZ_CP021905.1\|WP_000037081.1\|1971062_1972280_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	2.99224e-85
NZ_CP021905.1\|WP_001014423.1\|1976884_1977871_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	9.69605e-76
NZ_CP021905.1\|WP_000180460.1\|1969691_1969892_-\|DUF1128-family-protein	gnl\|CDD\|227177	COG4840, COG4840, Uncharacterized protein conserved in bacteria [Function unknown].	9.24488e-25
NZ_CP021905.1\|WP_000636142.1\|1975370_1976129_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.9498e-126
NZ_CP021905.1\|WP_000140179.1\|1982547_1983618_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NZ_CP021905.1\|WP_000544973.1\|1978697_1979429_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.79354e-120

>NZ_CP021905.1|WP_000636142.1|1975370_1976129_-|type-I-methionyl-aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
>NZ_CP021905.1|WP_001110178.1|1974767_1975154_-|hypothetical-protein
MNYVERYIEQFLRATVRNNIKHYLLMLDEKMKNLDDYMHYLITKKEQLSKLIDSLMLTLENKYIDIVEAFQIQCAREINNQEIENIKSELNKVEAYYAQIETQIQQTSTEKIATEKTSYLINYMNAVA
>NZ_CP021905.1|WP_000149064.1|1974051_1974753_-|cell-wall-active-antibiotics-response-protein
MTHKYISTQMLIIFTALMIIANFYYIFFEKIGFLLVLLLGCVLVYVGYLYFHKIRGLLAFWIGALLIAFTLLSNKYTIIILFVFLLLLIVRYLIHKFKPKKVVATDEVMTSPSFIKQKWFGEQRTPVYVYKWEDVQIQHGIGDLHIDLTKAANIKENNTIVVRHILGKVQVILPVNYNINLHVAAFYGSTYVNEKSYKVENNNIHIEEMMKPDNYTVNIYVSTFIGDVEVIYR
>NZ_CP021905.1|WP_001017131.1|1973011_1974055_-|sensor-histidine-kinase
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
>NZ_CP021905.1|WP_000153535.1|1972392_1973022_-|response-regulator-transcription-factor
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>NZ_CP021905.1|WP_000037081.1|1971062_1972280_+|YihY/virulence-factor-BrkB-family-protein
MSKKDHSSSKYLNSVKEAQEESKKKNKSNPKIDVDRTYIEPQQFQSKKPKKDDQVFFLSRLNKPAKYKKDSNFLSYLIYRIGKDDASGLAAQMTYHFVLAMFPMLLFLLTLLPFFNIKQSQITNMLSNAPAETSTLIKSVIGDITQNSSGGLLSIGLILAIWSASNGMTAIMNSFNVAYDVEDSRNGIVLKLLSVVFTVVMGVVFVVALALPTLGSVISHFLFGPLGFDEQVKWIFNLIRIVLPIIIIFIVFIVLYSVAPNVKTKLKSVLPGAVFTSIIWLAGSFGFGWYISNFGNYSKTYGSIAGIIILLLWLYITSFIIIVGAEINAIIHQRSVIKGKTPEEAALEHDDNNKNHYNENTRYEYDEDTNATHQRTYHVDEHPSDTYPEDDKNIKDKIVDKLKKD
>NZ_CP021905.1|WP_000428172.1|1970509_1970785_+|hypothetical-protein
MENKFVPGILIGAVIGGAISLADKSTRQALVQSVKDAKNGNRTRKPSKVSKIKDEVLYWKDVVEEIRRNNPELERSLKDAKETFVNRKNQR
>NZ_CP021905.1|WP_000228670.1|1970038_1970503_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIQDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>NZ_CP021905.1|WP_000180460.1|1969691_1969892_-|DUF1128-family-protein
MTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHD
>NZ_CP021905.1|WP_001793983.1|1968432_1969689_-|aminopeptidase
MGILTNYKEKLQQYAELLVKVGMNVQPKQPVFIRSSVETLELTHLIVEEAYRCGASDVRVVYSDPTLKRLKFENESVEHFANHEIKSYDVEARMDYVKRGAANLALISEDPDLMDGIDSQKLQAFQQQNARAFKGYMESVQKNQFPWVVAAFPSKAWAKRVYPELSVEEAYIKFIDEVFDIVRIDGNDPVENWRQHIANLSVYAQKLQQKNYHALHYVSEGTDLTVGLAKNHIWEDATSYVNGKEQAFIANIPTEEVFTAPDRNRVDGYVTNKLPLSYNGTIIDQFKLMFKDGEIIDFSAEKGEAVLKDLINTDEGSRRLGEVALVPDDSPISNRNTIFYNTLFDENAACHLAIGSAYAFNIQGGTEMTVEEKIASGLNDSNVHVDFMIGSSDLTIYGIFEDGSKELVFENGNWASTF
>NZ_CP021905.1|WP_001791533.1|1976389_1976563_-|hypothetical-protein
MCRLAGPQHREIGSTISTGNASWGVGPNTENFEKRNSTGNAGWGVGPNTEKLEHQFL
>NZ_CP021905.1|WP_001014423.1|1976884_1977871_+|aromatic-acid-exporter-family-protein
MNGQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQEIILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
>NZ_CP021905.1|WP_001643743.1|1978059_1978473_-|hypothetical-protein
MKPTKVILKDASYLHSKTSITFILKDVVIEEDNKIYYFDTSATFEDQEIKFEFALFDSDMDNLKYIEYDNPVTEIYFIEPDLHFTIIDFNQELLCIYIDFDSGLRHSNMVTESGVSLRINVTKSGFTKFINELVSLH
>NZ_CP021905.1|WP_001790257.1|1978501_1978612_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NZ_CP021905.1|WP_000544973.1|1978697_1979429_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHNFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEKQAKQVLIDRANRQKKSR
>NZ_CP021905.1|WP_001250339.1|1979430_1980744_-|Mur-ligase-family-protein
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNGDDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISRFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQAIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NZ_CP021905.1|WP_000949466.1|1981035_1981536_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEEAMFETHINYLTRIGDDSNALYLYEKELGTRTFDEE
>NZ_CP021905.1|WP_001790679.1|1981617_1981710_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NZ_CP021905.1|WP_000613738.1|1981926_1982481_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NZ_CP021905.1|WP_000140179.1|1982547_1983618_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYRNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSTRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI

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Crispr_ID: NZ_CP021905_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_7

1987097-1987400

Orphan

Consensus_repeat	Method
NTCTNTGTTNGGGNCCCNNC	CRT

5 spacers

DEDDh

The CRISPR arrays of NZ_CP021905_7

>merge|NZ_CP021905|7|1987097-1987400|CRT
TCTATGTTTGGGGCCCCACCCCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTATGTTGGGGCCCCGCCAACTTGCATTGTCTGTAGAATTTCTTTTCAAAATTCTCTATGTTTGGGGCCCCACCCCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTATGTTGGGGCCCCGCCAACTTGCATTGTCTGTAGAATTTCCTTTCGAAATTCTCTTTGTTGGGGCCCCACCCTAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCTTCTTTGTTGGGGCCCCAC

>NZ_CP021905|7|1|1987097-1987400|CRT
TCTATGTTTGGGGCCCCAC	CCCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGCT
TCTATGTTGGGGCCCCGCC	AACTTGCATTGTCTGTAGAATTTCTTTTCAAAATTC
TCTATGTTTGGGGCCCCAC	CCCAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGC
TTCTATGTTGGGGCCCCGC	CAACTTGCATTGTCTGTAGAATTTCCTTTCGAAATT
CTCTTTGTTGGGGCCCCAC	CCTAACTTGCACATTATTGTAAGCTGACAGAAAGTCAGC
TTCTTTGTTGGGGCCCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000949466.1\|1981035_1981536_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NZ_CP021905.1\|WP_000548777.1\|1983864_1984395_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
NZ_CP021905.1\|WP_000774553.1\|1994297_1996301_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP021905.1\|WP_001147874.1\|1984564_1985926_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_CP021905.1\|WP_000957023.1\|1991458_1992997_+\|sodium/proline-symporter-PutP	unknown	unknown	gnl\|CDD\|273981
NZ_CP021905.1\|WP_001165363.1\|1999368_1999671_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226893
NZ_CP021905.1\|WP_000027924.1\|1989330_1990788_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP021905.1\|WP_000831695.1\|1993085_1994285_-\|CamS-family-sex-pheromone-protein	unknown	unknown	gnl\|CDD\|227188
NZ_CP021905.1\|WP_001250339.1\|1979430_1980744_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_CP021905.1\|WP_001790679.1\|1981617_1981710_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001231458.1\|1986006_1986954_-\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|183982
NZ_CP021905.1\|WP_000613738.1\|1981926_1982481_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NZ_CP021905.1\|WP_000272063.1\|1998493_1999186_-\|heptaprenylglyceryl-phosphate-synthase	unknown	unknown	gnl\|CDD\|224560
NZ_CP021905.1\|WP_000170162.1\|1990789_1991092_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP021905.1\|WP_000545373.1\|1987890_1989318_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP021905.1\|WP_000544973.1\|1978697_1979429_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_CP021905.1\|WP_001791535.1\|1987705_1987852_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000992924.1\|1996304_1998497_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NZ_CP021905.1\|WP_000140179.1\|1982547_1983618_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NZ_CP021905.1\|WP_001790257.1\|1978501_1978612_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000949466.1\|1981035_1981536_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	1.15329e-74
NZ_CP021905.1\|WP_000548777.1\|1983864_1984395_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.54005e-11
NZ_CP021905.1\|WP_000774553.1\|1994297_1996301_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP021905.1\|WP_001147874.1\|1984564_1985926_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	0
NZ_CP021905.1\|WP_000957023.1\|1991458_1992997_+\|sodium/proline-symporter-PutP	gnl\|CDD\|273981	TIGR02121, Osmoregulated_proline_transporter, sodium/proline symporter. This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines].	0
NZ_CP021905.1\|WP_001165363.1\|1999368_1999671_-\|hypothetical-protein	gnl\|CDD\|226893	COG4496, COG4496, Uncharacterized protein conserved in bacteria [Function unknown].	1.66593e-59
NZ_CP021905.1\|WP_000027924.1\|1989330_1990788_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP021905.1\|WP_001250339.1\|1979430_1980744_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.60835e-98
NZ_CP021905.1\|WP_000831695.1\|1993085_1994285_-\|CamS-family-sex-pheromone-protein	gnl\|CDD\|227188	COG4851, CamS, Protein involved in sex pheromone biosynthesis [General function prediction only].	0
NZ_CP021905.1\|WP_001231458.1\|1986006_1986954_-\|diacylglycerol-kinase	gnl\|CDD\|183982	PRK13337, PRK13337, putative lipid kinase; Reviewed.	0
NZ_CP021905.1\|WP_000613738.1\|1981926_1982481_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
NZ_CP021905.1\|WP_000272063.1\|1998493_1999186_-\|heptaprenylglyceryl-phosphate-synthase	gnl\|CDD\|224560	COG1646, COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only].	2.53994e-99
NZ_CP021905.1\|WP_000170162.1\|1990789_1991092_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	5.296e-34
NZ_CP021905.1\|WP_000545373.1\|1987890_1989318_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP021905.1\|WP_000992924.1\|1996304_1998497_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP021905.1\|WP_000140179.1\|1982547_1983618_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NZ_CP021905.1\|WP_000544973.1\|1978697_1979429_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.79354e-120

>NZ_CP021905.1|WP_001231458.1|1986006_1986954_-|diacylglycerol-kinase
MRKRARIIYNPTSGKEQFKRELPDALIKLEKAGYETSAYATEKIGDATLEAERAMHENYDVLIAAGGDGTLNEVVNGIAEKPNRPKLGVIPMGTVNDFGRALHIPNDIMGALDVIIEGHSTKVDIGKMNNRYFINLAAGGQLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDGNVFQGEALLFFLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKSNLAELGHIMTLASRGEHTKHPKVIYEKAKAINISSFTDLQLNVDGEYGGKLPANFLNLERHIDVFAPNDIVNEELINNDHVDDNLIEE
>NZ_CP021905.1|WP_001147874.1|1984564_1985926_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLLNINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTVGMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMGSCLIQDSQHQEVMNEVKSILKDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMVIFVTNGKNWPQKNAVVEKILDAFPNVTSIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAIEYAQLTGNEVVLDTYCGIGTIGLYMAPHAKHVYGVEVVPSAIEDAQQNATINQCNNTTFVCGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPSTQQRDALLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
>NZ_CP021905.1|WP_000548777.1|1983864_1984395_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSAGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ
>NZ_CP021905.1|WP_000140179.1|1982547_1983618_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYRNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSTRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>NZ_CP021905.1|WP_000613738.1|1981926_1982481_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NZ_CP021905.1|WP_001790679.1|1981617_1981710_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NZ_CP021905.1|WP_000949466.1|1981035_1981536_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEEAMFETHINYLTRIGDDSNALYLYEKELGTRTFDEE
>NZ_CP021905.1|WP_001250339.1|1979430_1980744_-|Mur-ligase-family-protein
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNGDDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISRFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQAIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NZ_CP021905.1|WP_000544973.1|1978697_1979429_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHNFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEKQAKQVLIDRANRQKKSR
>NZ_CP021905.1|WP_001790257.1|1978501_1978612_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NZ_CP021905.1|WP_001791535.1|1987705_1987852_-|hypothetical-protein
MVADLDAIEGLFISIEVILLLTLFIVHVNGKNINFINALALIILRQTV
>NZ_CP021905.1|WP_000545373.1|1987890_1989318_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MHFETVIGLEVHVELKTDSKMFSPSPAHFGAEPNSNTNVIDLAYPGVLPVVNKRAVDWAMRAAMALNMEIATESKFDRKNYFYPDNPKAYQISQFDQPIGENGYIDIEVDGETKRIGITRLHMEEDAGKSTHKGEYSLVDLNRQGTPLIEIVSEPDIRSPKEAYAYLEKLRSIIQYTGVSDVKMEEGSLRCDANISLRPYGQEKFGTKAELKNLNSFNYVRKGLEYEEKRQEEELLSGGEIGQETRRFDESTGKTILMRVKEGSDDYRYFPEPDIVPLYIDDAWKERVRQTIPELPDERKAKYVNELGLPAYDAHVLTLTKEMSDFFESTIEHGADVKLTSNWLMGGVNEYLNKNQVELLDTKLTPENLAGMIKLIEDGTMSSKIAKKVFPELAAKGGNAKQIMEDNGLVQISDEATLLKFVNEALDNNEQSVEDYKNGKGKAMGFLVGQIMKASKGQANPQLVNQLLKQELDKR
>NZ_CP021905.1|WP_000027924.1|1989330_1990788_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MSIRYESVENLLTLIKDKKIKPSDVVKDIYDAIEETDPTIKSFLALDKENAIKKAQELDELQAKDQMDGKLFGIPMGIKDNIITNGLETTCASKMLEGFVPIYESTVMEKLHNENAVLIGKLNMDEFAMGGSTETSYFKKTVNPFDHKAVPGGSSGGSAAAVAAGLVPFSLGSDTGGSIRQPAAYCGVVGMKPTYGRVSRFGLVAFASSLDQIGPLTRNVKDNAIVLEAISGADANDSTSAPVDDVDFTSEIGKDIKGLKVALPKEYLGEGVADDVKEAVQNAVETLKSLGAVVEEVSLPNTKFGIPSYYVIASSEASSNLSRFDGIRYGYHSKEAHSLEELYKMSRSEGFGKEVKRRIFLGTFALSSGYYDAYYKKSQKVRTLIKNDFDKVFENYDVVVGPTAPTTAFNLGEEIDDPLTMYANDLLTTPVNLAGLPGISVPCGQSNGRPIGLQFIGKPFDEKTLYRVAYQYETQYNLHDVYEKL
>NZ_CP021905.1|WP_000170162.1|1990789_1991092_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDA
>NZ_CP021905.1|WP_000957023.1|1991458_1992997_+|sodium/proline-symporter-PutP
MLTMGTALSQQVDANWQTYIMIAVYFLILIVIGFYGYKQATGNLSEYMLGGRSIGPYITALSAGASDMSGWMIMGLPGSVYSTGLSAMWITIGLTLGAYINYFVVAPRLRVYTELAGDAITLPDFFKNRLNDKNNVLKIISGLIIVVFFTLYTHSGFVSGGKLFESAFGLDYHFGLILVAFIVIFYTFFGGYLAVSITDFFQGVIMLIAMVMVPIVAMMNLNGWGTFHDVAAMKPTNLNLFKGLSFIGIISLFSWGLGYFGQPHIIVRFMSIKSHKMLPKARRLGISWMAVGLLGAVAVGLTGIAFVPAYHIKLEDPETLFIVMSQVLFHPLVGGFLLAAILAAIMSTISSQLLVTSSSLTEDFYKLVRGEEKAKTHQKEFVMVGRLSVLAVAIVAIAIAWNPNDTILNLVGNAWAGFGASFSPLVLFALYWKGLTRAGAVSGMVSGALVVIVWIAWIKPLAHINEIFGLYEIIPGFIVSVIVTYVVSKLTKKPGAFVETDLNKVRDIVREK
>NZ_CP021905.1|WP_000831695.1|1993085_1994285_-|CamS-family-sex-pheromone-protein
MKRTLVLLITAIFILAACGNHKDDQAGKDNQKHNNSSNQVKEIATDKNVQGDNYRTLLPFKESQARGLLQDNMANSYNGGDFEDGLLNLSKEVFPTDKYLYQDGQFLDKKTINAYLNPKYTKREIDKMSEKDKKDKKANENLGLNPSHEGETDPEKIAEKSPAYLSNILEQDFYGGGDTKGKNIKGMTIGLAMNSVYYYKKEKDGPTFSKKLDDSEVKKQGKQMASEILSRLRENDDLKDIPIHFAIYKQSSEDSITPGEFITQATAEKSQTKLNEWHNINEKSALLPSSTAADYDENLNNNFKQFNDNLQSYFSNFTQAVGKVKFVDKKPQRLVVDLPIDYYGQAETIGITQYVTEQANKYFDKIDNYEIRIKDGNQPRALISKTKDDKEPQVHIYSN
>NZ_CP021905.1|WP_000774553.1|1994297_1996301_-|NAD-dependent-DNA-ligase-LigA
MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEFKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHVIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVSDIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEDAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
>NZ_CP021905.1|WP_000992924.1|1996304_1998497_-|DNA-helicase-PcrA
MNALLNHMNTEQSEAVKTTEGPLLIMAGAGSGKTRVLTHRIAYLLDEKDVSPYNVLAITFTNKAAREMKERVQKLVGDQAEVIWMSTFHSMCVRILRRDADRIGIERNFTIIDPTDQKSVIKDVLKNENIDSKKFEPRMFIGAISNLKNELKTPADAQKEATDYHSQMVATVYSGYQRQLSRNEALDFDDLIMTTINLFERVPEVLEYYQNKFQYIHVDEYQDTNKAQYTLVKLLASKFKNLCVVGDSDQSIYGWRGADIQNILSFEKDYPEANTIFLEQNYRSTKTILNAANEVIKNNSERKPKGLWTANTNGEKIHYYEAMTERDEAEFVIREIMKHQRNGKKYQDMAILYRTNAQSRVLEETFMKSNMPYTMVGGQKFYDRKEIKDLLSYLRIIANSNDDISLQRIINVPKRGVGPSSVEKVQNYALQNNISMFDALGEADFIGLSKKVTQECLNFYELIQSLIKEQEFLEIHEIVDEVLQKSGYREMLERENTLESRSRLENIDEFMSVPKDYEENTPLEEQSLINFLTDLSLVADIDEADTENGVTLMTMHSAKGLEFPIVFIMGMEESLFPHIRAIKSEDDHEMQEERRICYVAITRAEEVLYITHATSRMLFGRPQSNMPSRFLKEIPESLLENHSSGKRQTIQPKAKPFAKRGFSQRTTSTKKQVSSSDWNVGDKVMHKAWGEGMVSNVNEKNGSIELDIIFKSQGPKRLLAQFAPIEKKED
>NZ_CP021905.1|WP_000272063.1|1998493_1999186_-|heptaprenylglyceryl-phosphate-synthase
MYDIKKWRHIFKLDPAKHISDDDLDAICMSQTDAIMIGGTDDVTEDNVIHLMSRVRRYPLPLVLEISNIESVMPGFDFYFVPTVLNSTDVAFHNGTLLEALKTYGHSIDFEEVIFEGYVVCNADSKVAKHTKANTDLTTEDLEAYAQMVNHLYRLPVMYIEYSGIYGDVSKVQAVSEHLTETQLFYGGGISSEQQATEMAAIADTIIVGDIIYKDIKKALKTVKIKESSK
>NZ_CP021905.1|WP_001165363.1|1999368_1999671_-|hypothetical-protein
MQIEKLRGAALDELFDAILTLENREECYQFFDDLCTVNEIQSLSQRLQVAKMIKQGYTYATIEQESGASTATISRVKRSLQWGNDAYTMILDRMNIETNE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP021905_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_8

2181164-2181253

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP021905_8

>merge|NZ_CP021905|8|2181164-2181253|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCAGTTGATGCGCAGCATCCAACTGTGTTCCTCTATTTTTCAACTTTAGTTGTTAGGGGCTTCT

>NZ_CP021905|8|7|2181164-2181253|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCAGTTGATGCGCAGCATCCAACTGTGTTCCTCTATTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000521495.1\|2200867_2202223_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NZ_CP021905.1\|WP_000334466.1\|2185128_2186934_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP021905.1\|WP_000808817.1\|2176035_2176266_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001292150.1\|2191331_2191766_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
NZ_CP021905.1\|WP_000495684.1\|2180055_2181147_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000927367.1\|2189187_2191320_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP021905.1\|WP_001123310.1\|2173127_2173541_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP021905.1\|WP_000019741.1\|2178809_2179790_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP021905.1\|WP_001024099.1\|2177670_2178336_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP021905.1\|WP_073392962.1\|2181588_2181693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000083795.1\|2187614_2189153_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP021905.1\|WP_000908186.1\|2184114_2184897_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP021905.1\|WP_000160304.1\|2171653_2172364_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP021905.1\|WP_000648736.1\|2191765_2192872_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP021905.1\|WP_088356255.1\|2173989_2175363_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NZ_CP021905.1\|WP_000070866.1\|2172484_2172928_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP021905.1\|WP_000003759.1\|2178487_2178808_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP021905.1\|WP_001792784.1\|2182372_2182531_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001127959.1\|2176296_2177235_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP021905.1\|WP_000370937.1\|2183189_2184047_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000521495.1\|2200867_2202223_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP021905.1\|WP_000334466.1\|2185128_2186934_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP021905.1\|WP_001292150.1\|2191331_2191766_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	6.01856e-62
NZ_CP021905.1\|WP_000927367.1\|2189187_2191320_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.39374e-67
NZ_CP021905.1\|WP_001123310.1\|2173127_2173541_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	4.7919e-46
NZ_CP021905.1\|WP_000019741.1\|2178809_2179790_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.09175e-108
NZ_CP021905.1\|WP_001024099.1\|2177670_2178336_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.27205e-48
NZ_CP021905.1\|WP_000083795.1\|2187614_2189153_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP021905.1\|WP_000370937.1\|2183189_2184047_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.15818e-59
NZ_CP021905.1\|WP_000160304.1\|2171653_2172364_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NZ_CP021905.1\|WP_000648736.1\|2191765_2192872_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP021905.1\|WP_088356255.1\|2173989_2175363_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.65095e-06
NZ_CP021905.1\|WP_000070866.1\|2172484_2172928_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NZ_CP021905.1\|WP_000003759.1\|2178487_2178808_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NZ_CP021905.1\|WP_001127959.1\|2176296_2177235_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.00589e-128
NZ_CP021905.1\|WP_000908186.1\|2184114_2184897_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.75723e-107

>NZ_CP021905.1|WP_000495684.1|2180055_2181147_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLVIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVITIILFVVIHAVILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP021905.1|WP_000019741.1|2178809_2179790_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVIATIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHSHHAHHHAHVH
>NZ_CP021905.1|WP_000003759.1|2178487_2178808_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NZ_CP021905.1|WP_001024099.1|2177670_2178336_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NZ_CP021905.1|WP_001127959.1|2176296_2177235_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAFEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNGRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NZ_CP021905.1|WP_000808817.1|2176035_2176266_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NZ_CP021905.1|WP_088356255.1|2173989_2175363_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKTKHD
>NZ_CP021905.1|WP_001123310.1|2173127_2173541_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFTTLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFADNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP021905.1|WP_000070866.1|2172484_2172928_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP021905.1|WP_000160304.1|2171653_2172364_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NZ_CP021905.1|WP_073392962.1|2181588_2181693_-|hypothetical-protein
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK
>NZ_CP021905.1|WP_001792784.1|2182372_2182531_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NZ_CP021905.1|WP_000370937.1|2183189_2184047_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQKETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP021905.1|WP_000908186.1|2184114_2184897_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINEGDKWILYGLNGAGKTTLLNILNAYEPATTGYVNLFGKMPGKVGYSTETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP021905.1|WP_000334466.1|2185128_2186934_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP021905.1|WP_000083795.1|2187614_2189153_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWFPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLATLVSFVVAALIMKFTKEPKQDLEAATAQMETTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSLDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP021905.1|WP_000927367.1|2189187_2191320_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRITGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNLAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETRDKSSNMIDKDDVHIETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLISDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP021905.1|WP_001292150.1|2191331_2191766_+|mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEGNVDRIVQAKSAEEIKQVFEEADA
>NZ_CP021905.1|WP_000648736.1|2191765_2192872_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALATGHQYDVILADESKTTTRVNNVAAINSMQPSEELKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLAYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NZ_CP021905.1|WP_000521495.1|2200867_2202223_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK

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Crispr_ID: NZ_CP021905_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_9

2200178-2200379

Orphan

Consensus_repeat	Method
TCCTTGGTTGGCAGGTGCAGCTGGATGTGCTGTA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP021905_9

>merge|NZ_CP021905|9|2200178-2200379|PILER-CR
TGCTTGGTTGGCAGGTGCTGCTTGATTTCCAGGTTGTGCTTGTGCAGCGTTATTCGGATCAGCTTGATTACCTTGTCCAGCTGGTTGTGCTGTACCTGCTGCCGGTTGTGCTGCGCCTCCTGCTGGATTAGCCTGTCCACCTTGGTTTGCTGGTTGTGCTGCTGGTTGTCCTTGGTTGGCAGGTGCAGCTGGCTGTGCTGTA

>NZ_CP021905|9|1|2200178-2200379|PILER-CR
TGCTTGGTTGGCAGGTGCTGCTTGATTTCCAGGT	TGTGCTTGTGCAGCGTTATTCGGATCAGCTTGATTACCTTGTCCAGCT
GGTTGTGCTGTACCTGCTGCCGGTTGTGCTGCGC	CTCCTGCTGGATTAGCCTGTCCACCTTGGTTTGCTGGTTGTGCTGCTGGTTGTCCTTGGTTGGCAGGTGCAGCT
GGCTGTGCTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000521495.1\|2200867_2202223_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NZ_CP021905.1\|WP_000162591.1\|2204182_2205091_-\|arginase	unknown	unknown	gnl\|CDD\|212515
NZ_CP021905.1\|WP_000334466.1\|2185128_2186934_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP021905.1\|WP_000884730.1\|2217015_2218203_-\|UDPGP-type-1-family-protein	unknown	unknown	gnl\|CDD\|133036
NZ_CP021905.1\|WP_000047120.1\|2216313_2216997_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NZ_CP021905.1\|WP_001292150.1\|2191331_2191766_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
NZ_CP021905.1\|WP_000495684.1\|2180055_2181147_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000927367.1\|2189187_2191320_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP021905.1\|WP_000958522.1\|2211354_2212419_-\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|378455
NZ_CP021905.1\|WP_072435031.1\|2214197_2214671_-\|multidrug-efflux-transporter-SepA	unknown	unknown	gnl\|CDD\|374975
NZ_CP021905.1\|WP_000894028.1\|2202249_2203182_-\|YbbR-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227193
NZ_CP021905.1\|WP_000083795.1\|2187614_2189153_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP021905.1\|WP_000347896.1\|2203183_2203993_-\|TIGR00159-family-protein	unknown	unknown	gnl\|CDD\|224539
NZ_CP021905.1\|WP_001237527.1\|2214792_2216136_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP021905.1\|WP_000370937.1\|2183189_2184047_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP021905.1\|WP_001792784.1\|2182372_2182531_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001141016.1\|2212566_2214009_-\|multidrug-efflux-MFS-transporter-LmrS	unknown	unknown	gnl\|CDD\|129794
NZ_CP021905.1\|WP_000648736.1\|2191765_2192872_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP021905.1\|WP_073392962.1\|2181588_2181693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_000908186.1\|2184114_2184897_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000521495.1\|2200867_2202223_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP021905.1\|WP_000162591.1\|2204182_2205091_-\|arginase	gnl\|CDD\|212515	cd09989, Arginase, Arginase family. This family includes arginase, also known as arginase-like amidino hydrolase family, and related proteins. Arginase is a binuclear Mn-dependent metalloenzyme and catalyzes hydrolysis of L-arginine to L-ornithine and urea (Arg, EC 3.5.3.1), the reaction being the fifth and final step in the urea cycle, providing the path for the disposal of nitrogenous compounds. Arginase controls cellular levels of arginine and ornithine which are involved in protein biosynthesis, and in production of creatine, polyamines, proline and nitric acid. In vertebrates, at least two isozymes have been identified: type I (ARG1) cytoplasmic or hepatic liver-type arginase and type II (ARG2) mitochondrial or non-hepatic arginase. Point mutations in human arginase ARG1 gene lead to hyperargininemia with consequent mental disorders, retarded development and early death. Hyperargininemia is associated with a several-fold increase in the activity of the mitochondrial arginase (ARG2), causing persistent ureagenesis in patients. ARG2 overexpression plays a critical role in the pathophysiology of cholesterol mediated endothelial dysfunction. Thus, arginase is a therapeutic target to treat asthma, erectile dysfunction, atherosclerosis and cancer.	5.94976e-145
NZ_CP021905.1\|WP_000334466.1\|2185128_2186934_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP021905.1\|WP_000884730.1\|2217015_2218203_-\|UDPGP-type-1-family-protein	gnl\|CDD\|133036	cd04193, UDPGlcNAc_PPase, UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.	9.19785e-146
NZ_CP021905.1\|WP_001292150.1\|2191331_2191766_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	6.01856e-62
NZ_CP021905.1\|WP_072435031.1\|2214197_2214671_-\|multidrug-efflux-transporter-SepA	gnl\|CDD\|374975	pfam17080, SepA, Multidrug Resistance efflux pump. SepA is a drug efflux protein that is involved in bacterial multidrug resistance. It is predicted to have four transmembrane domains.	1.1244e-29
NZ_CP021905.1\|WP_000347896.1\|2203183_2203993_-\|TIGR00159-family-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	2.13611e-103
NZ_CP021905.1\|WP_000958522.1\|2211354_2212419_-\|P-loop-NTPase	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	5.47694e-116
NZ_CP021905.1\|WP_000894028.1\|2202249_2203182_-\|YbbR-like-domain-containing-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	4.21538e-117
NZ_CP021905.1\|WP_000083795.1\|2187614_2189153_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP021905.1\|WP_001237527.1\|2214792_2216136_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.31901e-37
NZ_CP021905.1\|WP_000370937.1\|2183189_2184047_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.15818e-59
NZ_CP021905.1\|WP_000047120.1\|2216313_2216997_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	4.64044e-66
NZ_CP021905.1\|WP_001141016.1\|2212566_2214009_-\|multidrug-efflux-MFS-transporter-LmrS	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.86453e-81
NZ_CP021905.1\|WP_000927367.1\|2189187_2191320_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.39374e-67
NZ_CP021905.1\|WP_000648736.1\|2191765_2192872_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP021905.1\|WP_000908186.1\|2184114_2184897_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.75723e-107

>NZ_CP021905.1|WP_000648736.1|2191765_2192872_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALATGHQYDVILADESKTTTRVNNVAAINSMQPSEELKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLAYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NZ_CP021905.1|WP_001292150.1|2191331_2191766_+|mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEGNVDRIVQAKSAEEIKQVFEEADA
>NZ_CP021905.1|WP_000927367.1|2189187_2191320_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRITGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNLAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETRDKSSNMIDKDDVHIETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLISDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP021905.1|WP_000083795.1|2187614_2189153_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWFPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLATLVSFVVAALIMKFTKEPKQDLEAATAQMETTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSLDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP021905.1|WP_000334466.1|2185128_2186934_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP021905.1|WP_000908186.1|2184114_2184897_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINEGDKWILYGLNGAGKTTLLNILNAYEPATTGYVNLFGKMPGKVGYSTETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP021905.1|WP_000370937.1|2183189_2184047_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQKETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP021905.1|WP_001792784.1|2182372_2182531_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NZ_CP021905.1|WP_073392962.1|2181588_2181693_-|hypothetical-protein
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK
>NZ_CP021905.1|WP_000495684.1|2180055_2181147_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLVIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVITIILFVVIHAVILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP021905.1|WP_000521495.1|2200867_2202223_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK
>NZ_CP021905.1|WP_000894028.1|2202249_2203182_-|YbbR-like-domain-containing-protein
MLESKWGLRFIAFLLALFFFLSVNNVFGNIFNTGNLGQKSSKTIQDVPVEILYNTKDLHLTKAPETVNVTISGPQSKIIKIENPEDLRVVIDLSNAKAGKYQEKYQVKGLADDIHYSVKPKLANITLENKVTKKMTVQPDVSQSDIDPLYKITKQEVSPQTVKITGGEEQLNDIAYLKATFKTNKKINGDTKDIAEVTAFDKKLNKLNVSIQPNEVNLQVKVEPFSKKVKVNVKQKGSLADDKELSSIDLEDKEIEIFGSRDDLQNISEVDAEVDLDGISESTEKTVKINLPEHVSKAEPSETKAYINVK
>NZ_CP021905.1|WP_000347896.1|2203183_2203993_-|TIGR00159-family-protein
MDFSNFFQNLSTLKIVTSILDLLIVWYVLYLLITVFKGTKAIQLLKGILVIVIGQQISMILNLTATSKLFDIVIQWGVLALIVIFQPEIRRALEQLGRGSFLKRYTSNTYSKDEEKLIQSVSKAVQYMAKRRIGALIVFEKETGLQDYIETGIAMDSNISQELLINVFIPNTPLHDGAMIIQGTKIAAAASYLPLSDSPKISKSLGTRHRAAVGISEVSDAFTVIVSEETGDISVTFDGKLRRDISNEIFEELLAEHWFGTRFQKKGVK
>NZ_CP021905.1|WP_000162591.1|2204182_2205091_-|arginase
MTKKKGIDIIGVPSTFGQRKLGVDLGPTAIRYAGLIPRLKQLDLDVNDKGDIKVSAVDIEKFQSEQNGLRNYDEIIDVTQKLNKEVSASIENNRFPLVLGGDHSIAIGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNSNVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVDGVHLSLDVDALDPLETPGTGTRVLGGLTYRESHFALELLHQSQSVTSMDLVEVNPLIDHNNHTAEQSVSLVGTFFGETLL
>NZ_CP021905.1|WP_000958522.1|2211354_2212419_-|P-loop-NTPase
MLTVDQVKELIGEIKDPIIDVPLKETEGIVEVSIKEEKEHVSVKVAMAQLGGAPQLDLQMAVVNVLKENGAKTVGIRFETLPEEKVNQFKPKEENKPKTIEGLLSQNNPVEFIAIASGKGGVGKSTVAVNLAVALAREGKKVGLVDADIYGFSVPDMMGIDEKPGINGKEVIPVERHGVKVISMAFFVEENAPVIWRGPMLGKMLTNFFTEVRWGDIEYLILDLPPGTGDVALDVHTMLPSSKEIIVTTPHPTAAFVAARAGAMAKHTDHSILGVIENMSYFESKETGNKEYVFGKGGGTKLADELNTQLLGELPLEQPSWNPKDFAPSIYQSDDRLGKIYSSIAQKVIAATNK
>NZ_CP021905.1|WP_001141016.1|2212566_2214009_-|multidrug-efflux-MFS-transporter-LmrS
MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLVNGVMIPLTAYLMDRIKTRPLYLAAMGTFLVGSIVAAMAPNFGVLMLARVIQAMGAGVLMPLMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIALVAFIFGLISISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPVVIGAMIISSIIIYLFIRRQFNISNALLNLSVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLALSALLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYLIVVYAIRMFSVSLLMMPINTTGINSLKNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFGAKIFSSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
>NZ_CP021905.1|WP_072435031.1|2214197_2214671_-|multidrug-efflux-transporter-SepA
MVMNYLKHKFYNLLTTIIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIVFAVEHLMDYFRKMLPENAYFRGATFHLISYMVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
>NZ_CP021905.1|WP_001237527.1|2214792_2216136_-|MFS-transporter
MRLKSIVTVIALILIMFMAAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLTRFKIIYIAIAGLTLFTVGSLMSGLSTHFSMLVISRVIQGFGSGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVVWTFHFPEEETVAKSKFDTKGITLFYIFIGLIMFALLNQQHLYLNIIGFVLAILVALRLFNVEKKVSSPFLPVAEFNRMITLVFITDLLTAVCLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHHIEAKLSRKVIYLSSFTLLLLSSIIIAFGIKLPILIACVLILSGLSFGYIYTKDSVIVQEETSPIQMKKMMSFYGLTKNLGASIGSTIMGYLYALKSGLFGANLHNILGVVSLISVGLIVVWLIFYREAASQTKE
>NZ_CP021905.1|WP_000047120.1|2216313_2216997_-|hemolysin-III-family-protein
MSKSSEKSNDTIVETFKDIIPLSFGEEIGNAASHGVAALLTLLVLPYAAVHSYIAYGTLASVSMSIYVISIFMMFISSTIYHSMQNETPHKYILRIIDHSMIYVAISGTYTPILLTVVGGWIGWTVFILLWGTTLWGILYKSIAVKVNQKLSLIVYLVMGWVGIILLPIIFIRTSWIFILFIFLGGVSYTIGAWFYAQKNRPYFHMIWHIFIVIASLLHLIAILYFM
>NZ_CP021905.1|WP_000884730.1|2217015_2218203_-|UDPGP-type-1-family-protein
MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQAKQLKELHRQTGHKIQWYIMTSDINHEETLAYFESHNYFGYDQESIHFFKQDNIVALSEAGQLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI

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Crispr_ID: NZ_CP021905_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021905_10

2258787-2258912

Orphan

Consensus_repeat	Method
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021905_10

>merge|NZ_CP021905|10|2258787-2258912|CRISPRCasFinder
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCACTGGTTTCTCATGATTTTTTAATGTTTTTATTTTGAGTTACTCGAAAATTTTCCTCTTTACTCGAAAGCTCACAAAACCCTTGATATCA

>NZ_CP021905|10|8|2258787-2258912|CRISPRCasFinder
CCTCTTTACTCGAAAGCTCACAAAACTCTTGATATCA	CTGGTTTCTCATGATTTTTTAATGTTTTTATTTTGAGTTACTCGAAAATTTT
CCTCTTTACTCGAAAGCTCACAAAACCCTTGATATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021905.1\|WP_000101625.1\|2267050_2267440_-\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP021905.1\|WP_000222271.1\|2249357_2251784_+\|polysaccharide-lyase-8-family-protein	unknown	unknown	gnl\|CDD\|238517
NZ_CP021905.1\|WP_000170975.1\|2260754_2261153_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP021905.1\|WP_000136272.1\|2258541_2258721_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236623
NZ_CP021905.1\|WP_001791582.1\|2249193_2249361_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001221836.1\|2261852_2262647_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP021905.1\|WP_000769709.1\|2254018_2254444_+\|MAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|367591
NZ_CP021905.1\|WP_000586768.1\|2263447_2264308_-\|energy-coupling-factor-transporter-ATPase	unknown	unknown	gnl\|CDD\|184205
NZ_CP021905.1\|WP_000389651.1\|2264304_2265114_-\|energy-coupling-factor-transporter-ATPase	unknown	unknown	gnl\|CDD\|184207
NZ_CP021905.1\|WP_000130145.1\|2255575_2257240_-\|acetolactate-synthase-AlsS	unknown	unknown	gnl\|CDD\|236312
NZ_CP021905.1\|WP_000569649.1\|2266031_2266976_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP021905.1\|WP_000204276.1\|2258969_2260406_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225420
NZ_CP021905.1\|WP_000791607.1\|2262651_2263458_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP021905.1\|WP_000850001.1\|2248504_2248951_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NZ_CP021905.1\|WP_000542274.1\|2265646_2266015_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP021905.1\|WP_001044451.1\|2251843_2252698_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP021905.1\|WP_001791584.1\|2257709_2257892_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021905.1\|WP_001250038.1\|2261166_2261604_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP021905.1\|WP_000179061.1\|2254834_2255539_-\|acetolactate-decarboxylase	unknown	unknown	gnl\|CDD\|226058
NZ_CP021905.1\|WP_000044369.1\|2252908_2253724_-\|hydrolase	unknown	unknown	gnl\|CDD\|319792

Protein	Function_ID	Function_description	E-value
NZ_CP021905.1\|WP_000101625.1\|2267050_2267440_-\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	2.01588e-89
NZ_CP021905.1\|WP_000222271.1\|2249357_2251784_+\|polysaccharide-lyase-8-family-protein	gnl\|CDD\|238517	cd01083, GAG_Lyase, Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.	0
NZ_CP021905.1\|WP_000170975.1\|2260754_2261153_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.2295e-82
NZ_CP021905.1\|WP_000136272.1\|2258541_2258721_-\|hypothetical-protein	gnl\|CDD\|236623	PRK09775, PRK09775, type II toxin-antitoxin system HipA family toxin YjjJ.	0.0004492
NZ_CP021905.1\|WP_000389651.1\|2264304_2265114_-\|energy-coupling-factor-transporter-ATPase	gnl\|CDD\|184207	PRK13648, cbiO, cobalt transporter ATP-binding subunit; Provisional.	0
NZ_CP021905.1\|WP_001221836.1\|2261852_2262647_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	1.21958e-120
NZ_CP021905.1\|WP_000769709.1\|2254018_2254444_+\|MAP-domain-containing-protein	gnl\|CDD\|367591	pfam03642, MAP, MAP domain. This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein). The protein has been found in a wide range of extracellular matrix proteins.	8.17372e-34
NZ_CP021905.1\|WP_000542274.1\|2265646_2266015_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	2.70058e-62
NZ_CP021905.1\|WP_000130145.1\|2255575_2257240_-\|acetolactate-synthase-AlsS	gnl\|CDD\|236312	PRK08617, PRK08617, acetolactate synthase AlsS.	0
NZ_CP021905.1\|WP_000569649.1\|2266031_2266976_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	1.89947e-175
NZ_CP021905.1\|WP_000204276.1\|2258969_2260406_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.62674e-63
NZ_CP021905.1\|WP_000791607.1\|2262651_2263458_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.81787e-49
NZ_CP021905.1\|WP_000850001.1\|2248504_2248951_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.81366e-41
NZ_CP021905.1\|WP_001044451.1\|2251843_2252698_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.20929e-22
NZ_CP021905.1\|WP_000586768.1\|2263447_2264308_-\|energy-coupling-factor-transporter-ATPase	gnl\|CDD\|184205	PRK13646, cbiO, energy-coupling factor transporter ATPase.	0
NZ_CP021905.1\|WP_001250038.1\|2261166_2261604_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	4.91074e-100
NZ_CP021905.1\|WP_000179061.1\|2254834_2255539_-\|acetolactate-decarboxylase	gnl\|CDD\|226058	COG3527, AlsD, Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism].	1.39507e-119
NZ_CP021905.1\|WP_000044369.1\|2252908_2253724_-\|hydrolase	gnl\|CDD\|319792	cd02605, HAD_SPP, sucrose-phosphatase, similar to Synechocystis sp PCC 6803 SPP. Sucrose-phosphatase (SPP; EC 3.1.3.24) catalyzes the dephosphorylation of sucrose-6(F)-phosphate (Suc6P)-the final step in the pathway of sucrose biosynthesis in plants and cyanobacteria. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.06188e-100

>NZ_CP021905.1|WP_000136272.1|2258541_2258721_-|hypothetical-protein
MTEIVEFLSDGKLASRLEIQETMGLQKSYTSELIAELKKLEIIGSEGRGPGTRYYLIRD
>NZ_CP021905.1|WP_001791584.1|2257709_2257892_-|hypothetical-protein
MIDSVFWKKAFIPVYFIVAMLVFLLFRFYIKTNNFSIYLMIIFLMCLGTASIIYNYKNNR
>NZ_CP021905.1|WP_000130145.1|2255575_2257240_-|acetolactate-synthase-AlsS
MTDKKYTAADMVIDTLKNNGVEYVFGIPGAKIDYLFNALIDDGPELIVTRHEQNAAMMAQGIGRLTGKPGVVLVTSGPGVSNLTTGLLTATSEGDPVLALGGQVKRNDLLRLTHQSIDNAALLKYSSKYSEEVQDPESLSEVMTNAIRIATSGKNGASFISIPQDVISSPVESKAISLCQKPNLGVPSEQDINDVIEAIKNASFPVLLAGMRSSSADETNAIRKLVERTNLPVVETFQGAGVISRELENHFFGRVGLFRNQVGDELLRKSDLVVTIGYDPIEYEASNWNKELETQIINIDEVQAEITNYMQPKKELIGNIAKTIEMISEKVDEPFINQQHLDELEQLRTHIDEETGIKATHEEGILHPVEIIESMQKVLTDDTTVTVDVGSHYIWMARNFRSYNPRHLLFSNGMQTLGVALPWAISAALVRPNTQVVSVAGDGGFLFSSQDLETAVRKNLNIIQLIWNDGKYNMVEFQEEMKYKRSSGVDFGPVDFVKYAESFGAKGLRVTNQEELEAAIKEGYETDGPVLIDIPVNYKDNIKLSTNMLPDVFN
>NZ_CP021905.1|WP_000179061.1|2254834_2255539_-|acetolactate-decarboxylase
MASVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHANEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISGLFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGAVVGFFTPELFHGIGSAGFHVHFANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDEDFINANIDYKDIADEIREAE
>NZ_CP021905.1|WP_000769709.1|2254018_2254444_+|MAP-domain-containing-protein
MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTMDGYHTVPYTISVDGITALHRTYFVFPENKKVLYQEIDSKVKNQLASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKKNDDAKNSIDPSTIKQIQIVVK
>NZ_CP021905.1|WP_000044369.1|2252908_2253724_-|hydrolase
MSKRLLLFDFDETYFKHNTNEEDLSHLREMEKLLEKLTNNNEVITVVLTGSTFQSVMDKMDQVNMTFKPLHIFSDLSSKMFTWNNGEYVESETYKKKVLSEPFLFEDIEDILHHISAQYNVEFIPQRAFEGNETHYNFYFHSTGNHNNDRRILEVLVRYANDQNYTARFSRSNPLAGDPENAYDIDFTPSNAGKLYATQFLMKKYNIPVKSILGFGDSGNDEAYLSYLEHAYLMSNSRDEALKQKFRLTKYPYYQGITLHVKEFVEGKYDY
>NZ_CP021905.1|WP_001044451.1|2251843_2252698_-|M23-family-metallopeptidase
MNKTNFGDYLNKSKSRKIYKIFDQNLKREFSYWQFRKLFKSYTWQSDVHELKVCTQNDGTIEQIWIDKANQFGVAVTWKDNSIIGFVMRPLINYDAIKNETTLKYAVPTTDCYEVFWGGDNELYNYHYLYPHQRYAIDLVIKENHKTYKNLGKVNADYFCFGKDIIAPANGTVEKVVNGVQDNSIGSTKESQFLGNYIVIKHAENEYSLIAHLQQYSIIVNEGQNVKYGDIIGKVGNSGNSTEPHIHFQVMNDKNIEACTSLKIRFINNRELIKGDVVCGLQGE
>NZ_CP021905.1|WP_000222271.1|2249357_2251784_+|polysaccharide-lyase-8-family-protein
MTYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTTDYEKLRNIWLDVNYGYDKYDENNPDMKKKFEATENEAEKLLKEMKTESDRKYLWESSKDLDTKSADMTRTYRNIEKISEAMKHKNTKLKTDENKTKVKDALEWLHKNAYGKEPDKKVADLTSNFKNKTSRNTNLNWWDYEIGTPRALTNTLILLQEDFTDEEKKKYTAPIKTFAPDSDKILSSVGKSEPAKGGNLVDISKVKLLESIIEEDKDMMKKSIDSFNTVFTYAQNSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPMIKETPFNDSNQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDTMDKSTKAKYKKIVKTSVESDSSYKQTDYLSSYSDISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKGLDFAFGLSMTSKNVARYESINGENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLDNEEPKSTDVKKSSKTFVGGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANDYKLYKDDTQTTNSDNQETNSLFLESTNSTQNNIGYHFLNESKITVKKESHTGKWSDINKSQKDIQKTDEYYEVTQKHSNTDSKYAYVLYPGLSKDVFKSKASKVTVVKQEDDFHVVKDNESVWAGINYSDSAKTFEINNTKVEVKAKGMFILTKKDDNTYECSFYNPESTNSVSDIESKISMTGYSIINKNTSTSNESGVRFELTK
>NZ_CP021905.1|WP_001791582.1|2249193_2249361_+|hypothetical-protein
MLKIWVIDCLYASTFFVDCLTVDSQLYTLTNFEKLNHYLIIIFIAHAQHKKETCQ
>NZ_CP021905.1|WP_000850001.1|2248504_2248951_-|MerR-family-transcriptional-regulator
MKTKEVVALMNISQDTLRYYEKVGVIPPVNRDENGYRIYNDNDLNWIYLVKNLRNAGVSIESLIEFCRLAQLPKNENIQAQQKQILNKQLEELNENLKTIHDARDLLQYKIDNYDNHIAKINASDNHIAKINASDNHDDNVERLWERK
>NZ_CP021905.1|WP_000204276.1|2258969_2260406_-|MarR-family-transcriptional-regulator
MTSSKYIEYLQTEVEGQLLDRKRASINPKDVAQHISAFANAEGGKLVIGIEDNGEISGFNHSKAKKKEVYIEAPFEHLYRIPKYTYEIIEVKKRDGTMDEILIFDIEPSYDAIITLKDDSVYLRINDKSRKLTHNQITNLEYDRGSRRFEEELVEYSSIEDVNEELVDEFKQLLNTNVDNEKLLKARGFMREGKLTVAGLLLFSNNINVYLPGARIRFMRYEGTKEESGTRLNIVKDITFDKALPVAIREARAFINTQLREYTFLGKEGRFVTLPEYPEFAWFEGMINSIVHRRYDNQGDHIRIKMFDDRLEISSPGALPASVTLENIKEERYSRNPKLAAALTQYKWVRESNEGVGRIFDEMKQYFLDDPVYSEPNNSSVQLALKNNIIARKKRETGRVSNIITPELFESLNEQQELIVRHLYNQGELTASKIANIIQRSVPTARKRLKELEEMNIISTHGSSKNDPKRTYYLLGFE
>NZ_CP021905.1|WP_000170975.1|2260754_2261153_-|30S-ribosomal-protein-S9
MTLAQVEYRGTGRRKNSVARVRLVPGEGNITVNNRDVREYLPFESLILDLNQPFDVTETKGNYDVLVNVHGGGFTGQAQAIRHGIARALLEADPEYRGSLKRAGLLTRDPRMKERKKPGLKAARRSPQFSKR
>NZ_CP021905.1|WP_001250038.1|2261166_2261604_-|50S-ribosomal-protein-L13
MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVDTGDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPERLIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELRG
>NZ_CP021905.1|WP_001221836.1|2261852_2262647_-|tRNA-pseudouridine(38-40)-synthase-TruA
MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRIHKRHVRIHPSSRTDRGVHAIQQYFHFDTDLNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQQRDPFQSGLKTFIPEPLDLDKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEVSDVPKLLESKNRKNVPFTAPAEGLYLEKIYLDENELLKDFGNDIKIHRKKSL
>NZ_CP021905.1|WP_000791607.1|2262651_2263458_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MKNKLIIGRYLPINSFVHHLDPRAKLMFVFLFIILIFFCHSPLTYLWMFALILFFMRLAKIQLWFLIKGLTPIFFFLIFTLMMHIFLTKGGYVLVEWHGITIETNGILEGLYISLRLIGIVMIATIMTLSTSPIDLTDAFERLLAPLKMFKLPVHQLSMIMSIALRFIPTLMDELDKIILAQKSRGSEISSGNIATRIKSFIPLLVPLFISAFQRAEELAVAMEVRGYDANVKRTSYRQLKWQLRDTLSLIMIIPIAIILFVLKYSGV
>NZ_CP021905.1|WP_000586768.1|2263447_2264308_-|energy-coupling-factor-transporter-ATPase
MIIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKTIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKEKLADWHIGLPEIVQLQYDFEQKHQTKLKDIALTEEAFVSLYKEWQHEK
>NZ_CP021905.1|WP_000389651.1|2264304_2265114_-|energy-coupling-factor-transporter-ATPase
MEDKNSVIVFKNVSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVSEALEQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTATEIFDHAEELTTIGLDLPFPIKINQMLGHQTSFLTYEGLVDQL
>NZ_CP021905.1|WP_000542274.1|2265646_2266015_-|50S-ribosomal-protein-L17
MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYTRILKQGPRRGDGAESVIIELV
>NZ_CP021905.1|WP_000569649.1|2266031_2266976_-|DNA-directed-RNA-polymerase-subunit-alpha
MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
>NZ_CP021905.1|WP_000101625.1|2267050_2267440_-|30S-ribosomal-protein-S11
MARKQVSRKRRVKKNIENGVAHIRSTFNNTIVTITDEFGNALSWSSAGALGFKGSKKSTPFAAQMASETASKSAMEHGLKTVEVTVKGPGPGRESAIRALQSAGLEVTAIRDVTPVPHNGCRPPKRRRV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP021905_2	2.1\|776523\|33\|NZ_CP021905\|CRISPRCasFinder	776523-776555	33	NZ_CP021905.1	1023189-1023221	1	0.97
NZ_CP021905_2	2.1\|776523\|33\|NZ_CP021905\|CRISPRCasFinder	776523-776555	33	NZ_CP021905.1	2331445-2331477	1	0.97
NZ_CP021905_6	6.1\|1976330\|29\|NZ_CP021905\|CRISPRCasFinder	1976330-1976358	29	NZ_CP021905.1	1976561-1976589	1	0.966
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	1987061-1987096	1	0.972
NZ_CP021905_4	4.1\|884020\|26\|NZ_CP021905\|CRISPRCasFinder	884020-884045	26	NZ_CP021905.1	2076345-2076370	2	0.923
NZ_CP021905_4	4.1\|884020\|26\|NZ_CP021905\|CRISPRCasFinder	884020-884045	26	NZ_CP021905.1	2136430-2136455	2	0.923
NZ_CP021905_6	6.1\|1976330\|29\|NZ_CP021905\|CRISPRCasFinder	1976330-1976358	29	NZ_CP021905.1	688677-688705	2	0.931
NZ_CP021905_6	6.1\|1976330\|29\|NZ_CP021905\|CRISPRCasFinder	1976330-1976358	29	NZ_CP021905.1	1023235-1023263	2	0.931
NZ_CP021905_6	6.1\|1976330\|29\|NZ_CP021905\|CRISPRCasFinder	1976330-1976358	29	NZ_CP021905.1	1049470-1049498	2	0.931
NZ_CP021905_6	6.1\|1976330\|29\|NZ_CP021905\|CRISPRCasFinder	1976330-1976358	29	NZ_CP021905.1	1650785-1650813	2	0.931
NZ_CP021905_7	7.1\|1987116\|40\|NZ_CP021905\|CRT	1987116-1987155	40	NZ_CP021905.1	789788-789827	2	0.95
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	256626-256661	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	334856-334891	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	743356-743391	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	776562-776597	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	1049405-1049440	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	1770682-1770717	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	2297095-2297130	2	0.944
NZ_CP021905_7	7.2\|1987175\|36\|NZ_CP021905\|CRT	1987175-1987210	36	NZ_CP021905.1	2437339-2437374	2	0.944
NZ_CP021905_7	7.3\|1987230\|39\|NZ_CP021905\|CRT	1987230-1987268	39	NZ_CP021905.1	789788-789826	2	0.949
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	256627-256662	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	334857-334892	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	743357-743392	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	776561-776596	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	1049404-1049439	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	1770683-1770718	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	2297094-2297129	2	0.944
NZ_CP021905_7	7.4\|1987288\|36\|NZ_CP021905\|CRT	1987288-1987323	36	NZ_CP021905.1	2437340-2437375	2	0.944

1. spacer 2.1|776523|33|NZ_CP021905|CRISPRCasFinder matches to position: 1023189-1023221, mismatch: 1, identity: 0.97

attgggaatccaatttctctttgttggggccca	CRISPR spacer
attgggaatccaatttctctgtgttggggccca	Protospacer
******************** ************

2. spacer 2.1|776523|33|NZ_CP021905|CRISPRCasFinder matches to position: 2331445-2331477, mismatch: 1, identity: 0.97

attgggaatccaatttctctttgttggggccca	CRISPR spacer
attgggaatccaatttctctttgttgggaccca	Protospacer
****************************.****

3. spacer 6.1|1976330|29|NZ_CP021905|CRISPRCasFinder matches to position: 1976561-1976589, mismatch: 1, identity: 0.966

cattatcgtaagctgactttttgtcagct	CRISPR spacer
cattatcgtaagctgacttttcgtcagct	Protospacer
*********************.*******

4. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 1987061-1987096, mismatch: 1, identity: 0.972

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttacattgtctgtagaatttcttttcaaaattc	Protospacer
*****.******************************

5. spacer 4.1|884020|26|NZ_CP021905|CRISPRCasFinder matches to position: 2076345-2076370, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggtgg	CRISPR spacer
cgcggccccaacacagaagctggcgg	Protospacer
** ********************.**

6. spacer 4.1|884020|26|NZ_CP021905|CRISPRCasFinder matches to position: 2136430-2136455, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggtgg	CRISPR spacer
cggggccccaacacaaaagctggcgg	Protospacer
***************.*******.**

7. spacer 6.1|1976330|29|NZ_CP021905|CRISPRCasFinder matches to position: 688677-688705, mismatch: 2, identity: 0.931

cattatcgtaagctgactttttgtcagct	CRISPR spacer
cattattgtaagctgacttttcgtcagct	Protospacer
******.**************.*******

8. spacer 6.1|1976330|29|NZ_CP021905|CRISPRCasFinder matches to position: 1023235-1023263, mismatch: 2, identity: 0.931

cattatcgtaagctgactttttgtcagct	CRISPR spacer
cattattgtaagctgacttttcgtcagct	Protospacer
******.**************.*******

9. spacer 6.1|1976330|29|NZ_CP021905|CRISPRCasFinder matches to position: 1049470-1049498, mismatch: 2, identity: 0.931

cattatcgtaagctgactttttgtcagct	CRISPR spacer
cattattgtaagctgacttttcgtcagct	Protospacer
******.**************.*******

10. spacer 6.1|1976330|29|NZ_CP021905|CRISPRCasFinder matches to position: 1650785-1650813, mismatch: 2, identity: 0.931

cattatcgtaagctgactttttgtcagct	CRISPR spacer
cattattgtaagctgacttttcgtcagct	Protospacer
******.**************.*******

11. spacer 7.1|1987116|40|NZ_CP021905|CRT matches to position: 789788-789827, mismatch: 2, identity: 0.95

cccaacttgcacattattgtaagctgacagaaagtcagct	CRISPR spacer
cccaacttgcacattattgtaagctggcggaaagtcagct	Protospacer
**************************.*.***********

12. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 256626-256661, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaattc	Protospacer
***********.*****************.******

13. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 334856-334891, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgtttgtagaatttcttttcgaaattc	Protospacer
************.****************.******

14. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 743356-743391, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgtttgtagaatttcttttcgaaattc	Protospacer
************.****************.******

15. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 776562-776597, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaattc	Protospacer
***********.*****************.******

16. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 1049405-1049440, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgcctgtagaatttcttttcgaaattc	Protospacer
***********.*****************.******

17. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 1770682-1770717, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaattc	Protospacer
****************************..******

18. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 2297095-2297130, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaattc	Protospacer
****************************..******

19. spacer 7.2|1987175|36|NZ_CP021905|CRT matches to position: 2437339-2437374, mismatch: 2, identity: 0.944

aacttgcattgtctgtagaatttcttttcaaaattc	CRISPR spacer
aacttgcattgtctgtagaatttctttttgaaattc	Protospacer
****************************..******

20. spacer 7.3|1987230|39|NZ_CP021905|CRT matches to position: 789788-789826, mismatch: 2, identity: 0.949

cccaacttgcacattattgtaagctgacagaaagtcagc	CRISPR spacer
cccaacttgcacattattgtaagctggcggaaagtcagc	Protospacer
**************************.*.**********

21. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 256627-256662, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgcctgtagaatttcttttcgaaatt	Protospacer
************.************.**********

22. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 334857-334892, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgtttgtagaatttcttttcgaaatt	Protospacer
*************.***********.**********

23. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 743357-743392, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgtttgtagaatttcttttcgaaatt	Protospacer
*************.***********.**********

24. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 776561-776596, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgcctgtagaatttcttttcgaaatt	Protospacer
************.************.**********

25. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 1049404-1049439, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgcctgtagaatttcttttcgaaatt	Protospacer
************.************.**********

26. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 1770683-1770718, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgtctgtagaatttctttttgaaatt	Protospacer
*************************.***.******

27. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 2297094-2297129, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgtctgtagaatttctttttgaaatt	Protospacer
*************************.***.******

28. spacer 7.4|1987288|36|NZ_CP021905|CRT matches to position: 2437340-2437375, mismatch: 2, identity: 0.944

caacttgcattgtctgtagaatttcctttcgaaatt	CRISPR spacer
caacttgcattgtctgtagaatttctttttgaaatt	Protospacer
*************************.***.******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

358367 : 376604

Staphylococcus_phage(90.91%)

coat,terminase,integrase

attL 359903:359920|attR 374793:374810

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001052483.1\|358367_358559_-	hypothetical protein	U3PCX8	Staphylococcus_phage	4.9e-23	80.0
WP_001261460.1\|358802_359099_+	30S ribosomal protein S6	NA	NA	NA	NA
WP_000934799.1\|359119_359623_+	single-stranded DNA-binding protein	A0A1W6JPL9	Staphylococcus_phage	1.2e-60	74.7
WP_000897044.1\|359674_359917_+	30S ribosomal protein S18	NA	NA	NA	NA
359903:359920	attL	NA	NA	NA	NA
WP_025174931.1\|360148_360868_-	type II toxin-antitoxin system PemK/MazF family toxin	Q4ZE81	Staphylococcus_phage	1.4e-22	29.4
WP_000270132.1\|360982_362197_-\|integrase	site-specific integrase	Q4ZE80	Staphylococcus_phage	1.9e-221	96.8
WP_000668212.1\|362652_363348_-	helix-turn-helix transcriptional regulator	Q4ZE79	Staphylococcus_phage	2.3e-09	62.5
WP_000794656.1\|363491_363704_+	helix-turn-helix transcriptional regulator	Q4ZE78	Staphylococcus_phage	2.6e-17	61.4
WP_000091734.1\|363704_363977_+	winged helix-turn-helix domain-containing protein	Q4ZE77	Staphylococcus_phage	3.9e-42	92.2
WP_031824147.1\|363988_364135_+	hypothetical protein	NA	NA	NA	NA
WP_001058486.1\|364127_364337_+	hypothetical protein	Q4ZE76	Staphylococcus_phage	1.7e-29	94.2
WP_001103945.1\|364339_364663_+	DUF1474 family protein	A0A1W6JQH0	Staphylococcus_phage	6.6e-20	58.2
WP_001002723.1\|364727_365597_+	hypothetical protein	Q4ZE74	Staphylococcus_phage	1.2e-164	96.5
WP_000447449.1\|365610_367320_+	DUF927 domain-containing protein	Q4ZE73	Staphylococcus_phage	0.0e+00	99.3
WP_000356936.1\|367631_368012_+	hypothetical protein	Q4ZE71	Staphylococcus_phage	1.5e-68	99.2
WP_001019780.1\|368008_368650_+	hypothetical protein	Q4ZE67	Staphylococcus_phage	5.9e-113	94.4
WP_001190612.1\|369166_369508_+	hypothetical protein	Q4ZE66	Staphylococcus_phage	2.4e-57	98.2
WP_038412914.1\|369519_370116_+	hypothetical protein	A0A2H4JBG0	uncultured_Caudovirales_phage	2.2e-29	38.9
WP_000448775.1\|370116_370335_+	hypothetical protein	NA	NA	NA	NA
WP_000771380.1\|370385_370913_+\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	2.1e-87	95.4
WP_001656917.1\|371044_371257_+	hypothetical protein	Q4ZE86	Staphylococcus_phage	5.4e-31	97.1
WP_001293091.1\|371253_371823_+\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	1.3e-100	97.9
WP_000801980.1\|372099_373068_+	Abi family protein	A0A0H4U080	Erysipelothrix_phage	2.7e-24	27.3
WP_001577971.1\|373363_373645_+	hypothetical protein	Q4ZE84	Staphylococcus_phage	3.7e-19	85.0
WP_000813311.1\|373762_374275_+	hypothetical protein	Q4ZE83	Staphylococcus_phage	1.4e-69	100.0
WP_001080636.1\|375044_376052_-	Abi family protein	NA	NA	NA	NA
374793:374810	attR	NA	NA	NA	NA
WP_001791349.1\|376481_376604_-	hypothetical protein	Q4ZE80	Staphylococcus_phage	3.0e-10	72.5

DBSCAN-SWA_2

721740 : 729559

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244416.1\|721740_722796_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|722795_723482_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|723456_723930_-	DoxX family protein	NA	NA	NA	NA
WP_001093552.1\|724270_724711_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637686.1\|724990_725575_-	hypothetical protein	NA	NA	NA	NA
WP_001062968.1\|725673_726387_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|726390_726810_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|726811_727480_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604508.1\|727830_728424_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	6.8e-39	44.0
WP_001217804.1\|728407_729559_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_3

741531 : 755669

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663016.1\|741531_742590_+	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	5.7e-20	26.5
WP_000197262.1\|742748_743291_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429002.1\|743842_744760_-	lipid kinase	A0A1V0SBJ0	Catovirus	8.2e-07	22.0
WP_031788440.1\|744850_744952_+	hypothetical protein	NA	NA	NA	NA
WP_000193750.1\|745029_746535_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930016.1\|746874_747375_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	66.2
WP_001068491.1\|747394_748261_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|749062_749461_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|749423_751529_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|751648_752620_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000876311.1\|752996_753968_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	7.8e-141	80.2
WP_001245566.1\|753954_754911_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	5.5e-06	60.0
WP_000616865.1\|754907_755669_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	7.2e-17	30.1

DBSCAN-SWA_4

925603 : 974427

Bacillus_virus(22.22%)

holin,transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000121211.1\|925603_926551_-\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.1e-184	100.0
WP_073392975.1\|926665_928135_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001067041.1\|928185_929172_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.8e-15	30.0
WP_000427776.1\|929174_930155_+	dipeptide ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.7e-16	34.1
WP_001574526.1\|930147_930798_+	ABC transporter permease	NA	NA	NA	NA
WP_001180271.1\|930809_931691_+	ABC transporter permease	NA	NA	NA	NA
WP_088356253.1\|931779_933347_-\|transposase	IS3-like element ISSau2 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.0e-49	51.8
WP_038412973.1\|933642_935289_+\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	5.9e-290	98.5
WP_000448930.1\|935315_936305_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|936599_936995_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217728.1\|937365_938085_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959276.1\|938205_939192_+	competence protein CoiA	NA	NA	NA	NA
WP_000082722.1\|939239_941048_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	9.3e-47	24.5
WP_000896691.1\|941507_942314_-	DsbA family protein	NA	NA	NA	NA
WP_000214067.1\|942336_942702_-	hypothetical protein	NA	NA	NA	NA
WP_000224620.1\|942805_943399_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242102.1\|943584_943932_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|943948_944584_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|944600_945410_+	NAD kinase	NA	NA	NA	NA
WP_000669938.1\|945406_946261_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062404.1\|946281_947667_+	magnesium transporter	NA	NA	NA	NA
WP_000395156.1\|947676_949521_+	sodium:proton antiporter	NA	NA	NA	NA
WP_000933195.1\|949798_950569_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|950764_951850_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570704.1\|952191_953760_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_000889176.1\|953902_954661_+	esterase family protein	NA	NA	NA	NA
WP_001060544.1\|954826_955552_+	hypothetical protein	NA	NA	NA	NA
WP_000600387.1\|957146_957656_+	hypothetical protein	NA	NA	NA	NA
WP_001794241.1\|957768_958977_-	MFS transporter	NA	NA	NA	NA
WP_000258649.1\|958936_960112_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340133.1\|960543_962028_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_001794242.1\|962008_962269_+	hypothetical protein	NA	NA	NA	NA
WP_001049957.1\|962268_963831_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	2.2e-36	28.2
WP_000928413.1\|964132_964936_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_001834048.1\|965154_967479_+\|protease	serine protease	W5SAB9	Pithovirus	4.0e-10	26.8
WP_000021872.1\|967495_968854_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414169.1\|968992_970504_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|970992_971562_-	competence protein ComK	NA	NA	NA	NA
WP_000876825.1\|971771_971990_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668822.1\|972070_973057_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|973255_973432_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|973446_974049_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099119695.1\|974349_974427_+\|holin	putative holin-like toxin	NA	NA	NA	NA

DBSCAN-SWA_5

1024717 : 1033190

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861570.1\|1024717_1025200_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.0e-22	44.7
WP_001010391.1\|1025186_1026311_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174050.1\|1026314_1027019_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	41.6
WP_000848351.1\|1027018_1027282_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666808.1\|1027283_1027955_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_000032734.1\|1027947_1030137_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.1e-140	39.2
WP_000483708.1\|1030115_1031600_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.5e-46	31.7
WP_000030814.1\|1031592_1032621_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	7.6e-62	41.4
WP_000238673.1\|1032623_1033190_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-29	40.1

DBSCAN-SWA_6

1481031 : 1564560

106

Staphylococcus_phage(82.28%)

tRNA,protease,head,tail,portal,integrase,holin,terminase,capsid

attL 1516936:1516964|attR 1558932:1558960

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858795.1\|1481031_1482324_-\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	4.3e-54	30.0
WP_000525060.1\|1482645_1485339_-	ATP-dependent helicase DinG	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000049917.1\|1485362_1486334_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000361536.1\|1486320_1487523_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.4e-35	42.5
WP_000690024.1\|1487527_1488670_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839927.1\|1488913_1489231_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_001827022.1\|1489566_1490247_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000154479.1\|1490318_1490906_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_000005208.1\|1490895_1491471_-	IDEAL domain-containing protein	G3MAV7	Bacillus_virus	4.6e-08	27.2
WP_000389521.1\|1491484_1492729_-	hypothetical protein	NA	NA	NA	NA
WP_000245891.1\|1492735_1494034_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776318.1\|1494043_1495108_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269936.1\|1495133_1496300_-	chorismate synthase	A0A291AU41	Pandoravirus	2.0e-34	32.3
WP_000442480.1\|1496768_1497218_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_001819897.1\|1497309_1498254_-	heptaprenyl diphosphate synthase subunit II	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774688.1\|1498270_1498996_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|1498998_1499571_-	heptaprenyl pyrophosphate synthase subunit A	NA	NA	NA	NA
WP_001043863.1\|1500001_1500274_-	DNA-binding protein HU	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161753.1\|1500444_1501443_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165530.1\|1501459_1502770_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133953.1\|1502991_1504167_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_001791199.1\|1504423_1504615_-	hypothetical protein	NA	NA	NA	NA
WP_001791200.1\|1504731_1504848_-	hypothetical protein	NA	NA	NA	NA
WP_000644393.1\|1504878_1505538_-	(d)CMP kinase	NA	NA	NA	NA
WP_000681747.1\|1505614_1506583_+	asparaginase	NA	NA	NA	NA
WP_001174260.1\|1506697_1507684_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_016186859.1\|1507844_1507931_-	hypothetical protein	NA	NA	NA	NA
WP_000069298.1\|1508068_1509529_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902107.1\|1509681_1511061_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	2.9e-56	33.3
WP_001163814.1\|1511050_1512004_-	hypothetical protein	NA	NA	NA	NA
WP_001151997.1\|1512111_1512360_+	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001186908.1\|1512465_1513011_-	ECF transporter S component	NA	NA	NA	NA
WP_001799520.1\|1513289_1513454_-	hypothetical protein	NA	NA	NA	NA
WP_000913246.1\|1513658_1514579_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001033756.1\|1514653_1514800_-	hypothetical protein	NA	NA	NA	NA
WP_000476887.1\|1514792_1515707_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000913238.1\|1515764_1516670_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_061390271.1\|1516759_1517011_-	hypothetical protein	A0ZS61	Staphylococcus_virus	2.4e-25	100.0
1516936:1516964	attL	NA	NA	NA	NA
WP_024937002.1\|1517193_1518177_-	Panton-Valentine bi-component leukocidin subunit F	A0A2I6PEU3	Staphylococcus_phage	4.0e-185	100.0
WP_000239544.1\|1518172_1519111_-	Panton-Valentine bi-component leukocidin subunit S	A0A2I6PF61	Staphylococcus_phage	1.7e-180	100.0
WP_000909204.1\|1519500_1520955_-	CHAP domain-containing protein	A0A2I6PF47	Staphylococcus_phage	7.5e-289	100.0
WP_000339141.1\|1520965_1521268_-\|holin	phage holin	A0A2I6PF56	Staphylococcus_phage	3.1e-48	100.0
WP_000340977.1\|1521393_1521768_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
WP_001040259.1\|1521823_1522111_-	hypothetical protein	G4KNR2	Staphylococcus_phage	9.9e-44	100.0
WP_001153681.1\|1522157_1522310_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_000582185.1\|1522299_1526085_-	hypothetical protein	C8CH32	Staphylococcus_phage	0.0e+00	99.4
WP_001154326.1\|1526100_1527591_-	hypothetical protein	D2JLF8	Staphylococcus_phage	4.1e-298	99.8
WP_001133542.1\|1527590_1532240_-\|tail	phage tail tape measure protein	D2JLF7	Staphylococcus_phage	0.0e+00	99.9
WP_000570353.1\|1532295_1532418_-	hypothetical protein	D2JLF6	Staphylococcus_phage	6.9e-15	100.0
WP_000442601.1\|1532477_1532924_-	hypothetical protein	D2JLF5	Staphylococcus_phage	5.4e-73	100.0
WP_000570653.1\|1532988_1533942_-	hypothetical protein	D2JLF4	Staphylococcus_phage	4.7e-175	100.0
WP_000611452.1\|1533942_1534323_-	hypothetical protein	D2JLF3	Staphylococcus_phage	5.8e-68	100.0
WP_000501244.1\|1534319_1534697_-	HK97 gp10 family phage protein	D2JLF2	Staphylococcus_phage	1.1e-61	100.0
WP_000975314.1\|1534696_1535032_-\|head,tail	head-tail adaptor protein	A7TWC7	Staphylococcus_phage	1.1e-59	100.0
WP_001177483.1\|1535018_1535351_-\|head,tail	phage head-tail adapter protein	D2JLF0	Staphylococcus_phage	2.1e-58	100.0
WP_001252099.1\|1535359_1535518_-	hypothetical protein	D2JLE9	Staphylococcus_phage	3.2e-20	100.0
WP_000849952.1\|1535553_1536801_-\|capsid	phage major capsid protein	D2JLE8	Staphylococcus_phage	1.7e-201	100.0
WP_000032525.1\|1536888_1537473_-\|head,protease	HK97 family phage prohead protease	D2JLE7	Staphylococcus_phage	9.8e-107	100.0
WP_011447040.1\|1537465_1538656_-\|portal	phage portal protein	D2JLE6	Staphylococcus_phage	1.8e-224	100.0
WP_000644968.1\|1538721_1538961_-	hypothetical protein	O80042	Staphylococcus_phage	7.0e-35	100.0
WP_000133304.1\|1538935_1540630_-\|terminase	phage terminase large subunit	D2JLE4	Staphylococcus_phage	0.0e+00	100.0
WP_000919026.1\|1540632_1541100_-\|terminase	phage terminase small subunit P27 family	D2JLE3	Staphylococcus_phage	1.1e-81	100.0
WP_000817289.1\|1541229_1541574_-	HNH endonuclease	D2JLE2	Staphylococcus_phage	4.2e-65	100.0
WP_000406191.1\|1541589_1542042_-	nucleoside triphosphate pyrophosphohydrolase family protein	D2JLE1	Staphylococcus_phage	1.4e-79	100.0
WP_000282744.1\|1542156_1542591_-	hypothetical protein	A0A1W6JPY3	Staphylococcus_phage	2.1e-74	100.0
WP_001794311.1\|1542613_1542814_-	DUF1514 domain-containing protein	D2JLD9	Staphylococcus_phage	1.4e-28	100.0
WP_001005262.1\|1542813_1543464_-	hypothetical protein	D2JLD8	Staphylococcus_phage	8.9e-117	100.0
WP_000501856.1\|1543622_1543787_-	transcriptional activator RinB	A0A2I6PDY4	Staphylococcus_phage	3.9e-21	100.0
WP_001125015.1\|1543774_1543975_-	hypothetical protein	A0A2I6PF22	Staphylococcus_phage	1.8e-28	100.0
WP_000195782.1\|1543949_1544138_-	DUF1381 domain-containing protein	A0A2I6PDV0	Staphylococcus_phage	2.1e-26	100.0
WP_001282074.1\|1544134_1544380_-	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	5.0e-36	100.0
WP_015978051.1\|1544416_1544944_-	ORF024	O80091	Staphylococcus_phage	8.6e-94	100.0
WP_001065065.1\|1544918_1545167_-	DUF1024 family protein	O80090	Staphylococcus_phage	3.1e-38	100.0
WP_001126839.1\|1545207_1545456_-	hypothetical protein	A0A1W6JPX8	Staphylococcus_phage	2.5e-43	100.0
WP_000029394.1\|1545456_1545816_-	hypothetical protein	B2ZYW3	Staphylococcus_phage	6.5e-61	99.2
WP_001187256.1\|1545816_1546002_-	DUF3113 family protein	B2ZYW2	Staphylococcus_phage	3.2e-27	100.0
WP_000049798.1\|1546006_1546411_-	DUF1064 domain-containing protein	G4KNP2	Staphylococcus_phage	1.6e-68	100.0
WP_001123688.1\|1546420_1546642_-	DUF3269 family protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
WP_000256594.1\|1546654_1546813_-	hypothetical protein	A0A2I6PDX0	Staphylococcus_phage	4.5e-22	98.1
WP_000803066.1\|1546806_1547586_-	AAA family ATPase	A0A1X9H042	Staphylococcus_phage	2.1e-144	98.8
WP_000190253.1\|1547595_1548366_-	hypothetical protein	A0A1W6JQ00	Staphylococcus_phage	6.4e-122	100.0
WP_000414755.1\|1548431_1548713_+	hypothetical protein	A0A1W6JPU7	Staphylococcus_phage	2.6e-49	100.0
WP_001199439.1\|1548851_1549523_-	hypothetical protein	A7TWM9	Staphylococcus_phage	2.0e-127	100.0
WP_011447037.1\|1549535_1550036_-	single-strand DNA-binding protein	A7TWM8	Staphylococcus_phage	7.2e-90	100.0
WP_000139746.1\|1550119_1550899_-	ATP-binding protein	Q4ZBV1	Staphylococcus_virus	9.6e-142	99.6
WP_000815401.1\|1550891_1551113_-	DUF2483 domain-containing protein	A7TWM6	Staphylococcus_phage	3.2e-34	100.0
WP_001556704.1\|1551122_1551383_-	DUF1108 family protein	G4KNN5	Staphylococcus_phage	2.0e-43	100.0
WP_000829610.1\|1551387_1551705_-	hypothetical protein	A0A2I6PEL3	Staphylococcus_phage	3.9e-33	100.0
WP_001285954.1\|1551793_1551955_-	DUF1270 domain-containing protein	A7TWM3	Staphylococcus_phage	8.6e-21	100.0
WP_001124198.1\|1551966_1552230_-	helix-turn-helix domain-containing protein	A0A2I6PEL8	Staphylococcus_phage	2.5e-46	100.0
WP_001037095.1\|1552259_1552478_-	hypothetical protein	A0A2I6PDV4	Staphylococcus_phage	5.0e-32	100.0
WP_001025595.1\|1552474_1552801_-	hypothetical protein	G4KNN2	Staphylococcus_phage	5.4e-54	100.0
WP_000801108.1\|1552856_1553084_+	hypothetical protein	A7TWL9	Staphylococcus_phage	1.7e-38	100.0
WP_000389906.1\|1553085_1553277_-	hypothetical protein	A7TWL8	Staphylococcus_phage	2.8e-26	100.0
WP_000351245.1\|1553333_1553873_+	hypothetical protein	A7TW92	Staphylococcus_phage	1.5e-96	99.4
WP_000435341.1\|1553896_1554157_-	transcriptional regulator	A7TW91	Staphylococcus_phage	2.7e-40	100.0
WP_000639923.1\|1554169_1554412_-	DUF739 family protein	A0A1X9H035	Staphylococcus_phage	1.6e-39	100.0
WP_001083975.1\|1554575_1555292_+	helix-turn-helix domain-containing protein	A0A1X9H038	Staphylococcus_phage	5.4e-131	100.0
WP_001557601.1\|1555303_1556158_+	restriction endonuclease	A0A1X9H037	Staphylococcus_phage	7.3e-151	100.0
WP_000109192.1\|1556374_1556560_+	hypothetical protein	A0A1X9H0K5	Staphylococcus_phage	1.9e-24	98.4
WP_001795334.1\|1556759_1556906_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.2e-16	100.0
WP_000191466.1\|1556902_1557517_-	hypothetical protein	A0A2I6PEZ0	Staphylococcus_phage	6.7e-106	100.0
WP_000264751.1\|1557642_1558848_+\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	7.7e-223	100.0
WP_001794062.1\|1558890_1560933_-	hypothetical protein	B5WZK7	Staphylococcus_phage	1.1e-38	44.1
1558932:1558960	attR	NA	NA	NA	NA
WP_000987777.1\|1562102_1563854_-	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-21	33.6
WP_000064078.1\|1563834_1564560_-	response regulator transcription factor	W8CYM9	Bacillus_phage	3.5e-45	43.0

DBSCAN-SWA_7

1622403 : 1630715

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1622403_1623189_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924211.1\|1623314_1624205_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062173.1\|1624214_1625561_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	1.4e-55	34.0
WP_000683921.1\|1625674_1626775_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	3.0e-08	30.6
WP_000624581.1\|1626777_1627455_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1627585_1628692_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217253.1\|1628915_1630715_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0

DBSCAN-SWA_8

1700139 : 1709182

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1700139_1700658_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595001.1\|1700679_1702953_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	6.2e-64	29.3
WP_000749802.1\|1703155_1705435_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1705709_1705970_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1705988_1707128_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019178.1\|1707150_1708176_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1708177_1709182_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

1832360 : 1901257

Staphylococcus_phage(93.02%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050525.1\|1832360_1838930_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	3.7e-295	88.6
WP_000836472.1\|1839253_1839565_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
WP_001108721.1\|1839586_1842001_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	98.7
WP_001025064.1\|1842292_1843474_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	9.6e-218	99.7
WP_000526541.1\|1843583_1844537_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	6.4e-79	99.3
WP_000764425.1\|1844533_1845097_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	1.1e-99	95.7
WP_000757543.1\|1845215_1845617_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1846189_1847017_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014937042.1\|1847019_1847139_-	hypothetical protein	NA	NA	NA	NA
WP_001196351.1\|1847250_1848252_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	5.0e-183	99.1
WP_001008553.1\|1848373_1848838_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.9e-69	98.1
WP_001159032.1\|1848850_1850032_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_000493891.1\|1850042_1850675_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.4e-112	99.0
WP_001819953.1\|1850681_1851713_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.8e-195	98.3
WP_001261683.1\|1852205_1853708_-	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	5.0e-30	98.6
WP_000221190.1\|1854350_1854665_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	1.3e-52	98.1
WP_000989104.1\|1854664_1855957_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	2.6e-216	95.1
WP_001032833.1\|1856043_1856898_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1857173_1857398_-	hypothetical protein	NA	NA	NA	NA
WP_000671059.1\|1857596_1858067_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	7.7e-70	85.8
WP_001152695.1\|1858179_1858623_+	competence protein ComK	NA	NA	NA	NA
WP_001030476.1\|1858609_1859053_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-49	77.4
WP_001168914.1\|1859350_1859986_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000492901.1\|1860152_1860773_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001096494.1\|1861230_1861944_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091444.1\|1862202_1862505_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1862759_1863125_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623482.1\|1863121_1863475_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.2e-19	95.7
WP_000453316.1\|1863724_1864558_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-158	99.6
WP_000366165.1\|1864769_1865678_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	9.8e-138	99.7
WP_000933818.1\|1865802_1866996_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	5.7e-218	99.2
WP_000109909.1\|1867367_1868960_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_001801476.1\|1869252_1869999_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	3.3e-139	97.2
WP_000672010.1\|1870003_1870477_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	9.5e-84	98.1
WP_000718107.1\|1870542_1870800_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778539.1\|1870796_1871798_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.5e-183	96.7
WP_000348372.1\|1871802_1873281_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.4e-282	97.2
WP_016186903.1\|1873439_1873895_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.5e-75	94.5
WP_001834081.1\|1874197_1874848_+	hypothetical protein	A0A2H4PQM8	Staphylococcus_phage	2.5e-42	83.8
WP_000070654.1\|1874928_1875924_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	3.8e-74	97.2
WP_000669038.1\|1875999_1876626_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	4.5e-81	84.1
WP_000627550.1\|1876666_1877011_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	5.1e-55	94.7
WP_000414220.1\|1877108_1877531_+	hypothetical protein	NA	NA	NA	NA
WP_001093574.1\|1877829_1879197_-	FRG domain-containing protein	NA	NA	NA	NA
WP_000125075.1\|1879196_1879766_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.2e-39	54.8
WP_000747804.1\|1879958_1880405_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001801861.1\|1880855_1880951_+	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_001791232.1\|1881073_1881175_+	hypothetical protein	NA	NA	NA	NA
WP_001037039.1\|1881349_1881793_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000731421.1\|1881792_1882236_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001819963.1\|1885737_1886097_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000619920.1\|1886324_1886774_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001053714.1\|1886816_1888427_+	hypothetical protein	NA	NA	NA	NA
WP_000095390.1\|1888441_1888741_+	secretion protein	NA	NA	NA	NA
WP_000413389.1\|1889002_1890820_-	hypothetical protein	NA	NA	NA	NA
WP_000072622.1\|1890856_1892011_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	7.8e-39	36.3
WP_001794363.1\|1892003_1893743_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	3.2e-286	98.6
WP_001038742.1\|1893922_1894642_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.0e-129	98.3
WP_001038734.1\|1894811_1895528_-\|protease	serine protease SplE	A0A2H4PQN5	Staphylococcus_phage	6.6e-129	97.1
WP_001038730.1\|1895691_1896408_-\|protease	serine protease	A0A2H4PQN5	Staphylococcus_phage	2.4e-86	64.7
WP_001038765.1\|1896574_1897291_-\|protease	serine protease	A0A2H4PQN5	Staphylococcus_phage	7.9e-82	62.2
WP_001039022.1\|1897414_1898134_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	6.4e-124	93.7
WP_000595635.1\|1899148_1899664_+	membrane protein	NA	NA	NA	NA
WP_000711496.1\|1899910_1901257_+	DUF4041 domain-containing protein	M1NRY5	Streptococcus_phage	6.7e-66	51.3

DBSCAN-SWA_10

2042241 : 2056391

Staphylococcus_phage(68.42%)

coat,terminase,integrase

attL 2039433:2039452|attR 2054413:2054432

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2039433:2039452	attL	NA	NA	NA	NA
WP_000801980.1\|2042241_2043210_-	Abi family protein	A0A0H4U080	Erysipelothrix_phage	2.7e-24	27.3
WP_001293091.1\|2043486_2044056_-\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	1.3e-100	97.9
WP_001656917.1\|2044052_2044265_-	hypothetical protein	Q4ZE86	Staphylococcus_phage	5.4e-31	97.1
WP_000771380.1\|2044396_2044924_-\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	2.1e-87	95.4
WP_000448775.1\|2044974_2045193_-	hypothetical protein	NA	NA	NA	NA
WP_038413068.1\|2045193_2045790_-	hypothetical protein	A0A2H4JBG0	uncultured_Caudovirales_phage	5.8e-30	39.4
WP_001161492.1\|2045801_2046143_-	hypothetical protein	Q4ZE66	Staphylococcus_phage	5.4e-57	97.3
WP_038413070.1\|2046489_2047131_-	pathogenicity island protein	Q4ZE67	Staphylococcus_phage	6.5e-112	93.9
WP_000998182.1\|2047127_2047412_-	hypothetical protein	A0A1W6JQE4	Staphylococcus_phage	1.0e-45	92.6
WP_001039171.1\|2047413_2047776_-	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	7.5e-65	98.3
WP_001834090.1\|2048072_2049542_-	hypothetical protein	A0A1W6JQD6	Staphylococcus_phage	1.3e-288	99.4
WP_001002839.1\|2049558_2050428_-	hypothetical protein	A0A1W6JQL5	Staphylococcus_phage	3.1e-157	93.8
WP_001103929.1\|2050491_2050809_-	DUF1474 family protein	A0A1W6JQH0	Staphylococcus_phage	5.5e-19	52.3
WP_001058486.1\|2050811_2051021_-	hypothetical protein	Q4ZE76	Staphylococcus_phage	1.7e-29	94.2
WP_000481972.1\|2051156_2051474_-	helix-turn-helix domain-containing protein	A0A1W6JQE0	Staphylococcus_phage	5.1e-49	95.2
WP_000595329.1\|2051487_2052129_-	phage repressor protein	A0A2H4JB17	uncultured_Caudovirales_phage	2.3e-96	83.6
WP_000448765.1\|2052132_2052345_-	helix-turn-helix transcriptional regulator	A0A2H4JB11	uncultured_Caudovirales_phage	3.0e-05	44.4
WP_001070979.1\|2052498_2053161_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000024832.1\|2053173_2054346_+\|integrase	site-specific integrase	A0A1W6JQD3	Staphylococcus_phage	2.0e-215	96.2
WP_000240651.1\|2054414_2056031_-	chaperonin GroEL	A0A240F779	uncultured_virus	2.6e-157	54.7
2054413:2054432	attR	NA	NA	NA	NA
WP_000917289.1\|2056106_2056391_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021906

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP021905

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection