CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017090	Staphylococcus aureus strain ISU935, complete genome	11 crisprs	cas3,DEDDh,DinG,csa3,TnsE_C,RT,WYL	6	1	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017090_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_1

426420-426521

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_1

>merge|NZ_CP017090|1|426420-426521|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>NZ_CP017090|1|1|426420-426521|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_000746679.1\|419666_420293_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
NZ_CP017090.1\|WP_000793023.1\|429914_431183_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468
NZ_CP017090.1\|WP_000991018.1\|424171_425560_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NZ_CP017090.1\|WP_000868256.1\|419013_419397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000424963.1\|432711_434253_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP017090.1\|WP_088401672.1\|423336_424092_+\|oxygen-insensitive-NADPH-nitroreductase	unknown	unknown	gnl\|CDD\|380322
NZ_CP017090.1\|WP_000264071.1\|431220_432687_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NZ_CP017090.1\|WP_001792089.1\|425644_425743_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000763767.1\|428416_428824_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378584
NZ_CP017090.1\|WP_000159787.1\|436396_436669_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NZ_CP017090.1\|WP_000041880.1\|435293_435998_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP017090.1\|WP_000421410.1\|429336_429915_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NZ_CP017090.1\|WP_000551643.1\|434365_434902_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000466748.1\|417689_417941_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP017090.1\|WP_000956137.1\|426537_427494_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP017090.1\|WP_000158375.1\|418366_418948_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP017090.1\|WP_000930514.1\|420736_422260_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NZ_CP017090.1\|WP_000394698.1\|427611_428274_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000052781.1\|422275_422845_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NZ_CP017090.1\|WP_000211677.1\|417979_418189_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_000746679.1\|419666_420293_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.15385e-71
NZ_CP017090.1\|WP_000991018.1\|424171_425560_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NZ_CP017090.1\|WP_000424963.1\|432711_434253_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP017090.1\|WP_088401672.1\|423336_424092_+\|oxygen-insensitive-NADPH-nitroreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.87618e-88
NZ_CP017090.1\|WP_000264071.1\|431220_432687_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NZ_CP017090.1\|WP_000793023.1\|429914_431183_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	5.74823e-170
NZ_CP017090.1\|WP_000466748.1\|417689_417941_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.58864e-09
NZ_CP017090.1\|WP_000159787.1\|436396_436669_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.23077e-11
NZ_CP017090.1\|WP_000041880.1\|435293_435998_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	5.38181e-08
NZ_CP017090.1\|WP_000421410.1\|429336_429915_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119
NZ_CP017090.1\|WP_000763767.1\|428416_428824_-\|hypothetical-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.17298e-12
NZ_CP017090.1\|WP_000956137.1\|426537_427494_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00265416
NZ_CP017090.1\|WP_000158375.1\|418366_418948_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	2.4566e-49
NZ_CP017090.1\|WP_000930514.1\|420736_422260_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NZ_CP017090.1\|WP_000052781.1\|422275_422845_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124

>NZ_CP017090.1|WP_001792089.1|425644_425743_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNLVEKGEKG
>NZ_CP017090.1|WP_000991018.1|424171_425560_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLVYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKRAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLIILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFESNDNAALTSH
>NZ_CP017090.1|WP_088401672.1|423336_424092_+|oxygen-insensitive-NADPH-nitroreductase
MSDYVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSDLIQR
>NZ_CP017090.1|WP_000052781.1|422275_422845_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>NZ_CP017090.1|WP_000930514.1|420736_422260_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDEKSKELKELLTEISDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKNLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMSTGEEHLLNLDGIFVQIGLLPNTSWLKDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NZ_CP017090.1|WP_000746679.1|419666_420293_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASALILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>NZ_CP017090.1|WP_000868256.1|419013_419397_-|hypothetical-protein
MKVRITFIILAILSTIVCLFLAAMHPTGPNTVTFEQPYLFTLNIILMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFISAIITLAIGGKSVDKNDSH
>NZ_CP017090.1|WP_000158375.1|418366_418948_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQKDDIVIVAHQVVIRCLMVYFNKVSREEAVDLKVENCKPYIIE
>NZ_CP017090.1|WP_000211677.1|417979_418189_-|hypothetical-protein
MTTQSFIFMNIILLDGATQRHPFFICQILAFLFPKFPHINLLLFYPILSTFSNIIIHIDHFHANKKDDN
>NZ_CP017090.1|WP_000466748.1|417689_417941_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MFGFIGMLIVGGLIGWAAGAIMGKDIPGGILGNIIAGIIGSWVGGKLFGQWGPELGSIYILPALIGSIILIAIVTLILRAMRK
>NZ_CP017090.1|WP_000956137.1|426537_427494_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKVLAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNENAAETSNKEATVDADAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>NZ_CP017090.1|WP_000394698.1|427611_428274_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>NZ_CP017090.1|WP_000763767.1|428416_428824_-|hypothetical-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHKEVQEHNSAYEEIDITHFAEASKGPKA
>NZ_CP017090.1|WP_000421410.1|429336_429915_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>NZ_CP017090.1|WP_000793023.1|429914_431183_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>NZ_CP017090.1|WP_000264071.1|431220_432687_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>NZ_CP017090.1|WP_000424963.1|432711_434253_+|glutamine-hydrolyzing-GMP-synthase
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>NZ_CP017090.1|WP_000551643.1|434365_434902_-|hypothetical-protein
MHNKNEFNKKLKDFIGSDKRMALVKGYINEYKLTTVLRALNNSDYTKGTIHTRSIGNLKQIVDNRIIPKNITQNKIFKLSNLTLEVNLYERNTIYHGDFAIYYPVESALIIETDTPRLINHINNNPVQKIFIITTNDWSFNTLELEKIVDETIIYDLKQEDPKQYEILYKNKHGKLPY
>NZ_CP017090.1|WP_000041880.1|435293_435998_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSKNINQANSKLNTSNKKLKQAYSKSDSKNMKVIYMPHWLEFYSIAIHSDVTSNKKRYYKSFSRGTVVYVKLGSNIGSEFSGNHFCVILDNKDNKGKETVTIVPLSSKGNKNYLKLNESVLNLTATDLKKQIIDISSKVQALTQKYRDIDIKLSTEDKKLLSNLNQKANELYRVIGVYSKHKGKDTYVNISAITTISKRRISKINDSDPTGTIIISEDDMNEIEKQLKIKFFSN
>NZ_CP017090.1|WP_000159787.1|436396_436669_-|transposase
MTKERRTFSSEFKLQMVRLYKNGKLKNEIIRKYDLKPSIISNSIKQHQNTGPFNHQDNLKSDEKELIKLRKEVQHLKMEHDVLKQILKLI

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Crispr_ID: NZ_CP017090_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_2

780611-780693

Orphan

Consensus_repeat	Method
CCAATTTCTACAGACAATGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_2

>merge|NZ_CP017090|2|780611-780693|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGGCGGGGCCCCAACATAGAGAAATTGGAACGCCAATTTCTACAGACAATGCAAGTTGG

>NZ_CP017090|2|2|780611-780693|CRISPRCasFinder
CCAATTTCTACAGACAATGCAAGTTGG	CGGGGCCCCAACATAGAGAAATTGGAACG
CCAATTTCTACAGACAATGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_000499195.1\|790296_790452_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000022323.1\|768212_769217_+\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224895
NZ_CP017090.1\|WP_000855514.1\|786921_789027_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236069
NZ_CP017090.1\|WP_000180991.1\|776768_778283_+\|ABC-transporter-permease/substrate-binding-protein	unknown	unknown	gnl\|CDD\|270328
NZ_CP017090.1\|WP_000193751.1\|782527_784033_-\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NZ_CP017090.1\|WP_000983677.1\|773795_775577_+\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NZ_CP017090.1\|WP_000663030.1\|778522_779581_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235106
NZ_CP017090.1\|WP_000562498.1\|789144_790116_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NZ_CP017090.1\|WP_000197262.1\|779919_780462_+\|5'-3'-deoxyribonucleotidase	unknown	unknown	gnl\|CDD\|226895
NZ_CP017090.1\|WP_031760357.1\|782348_782450_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000525106.1\|771900_773784_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP017090.1\|WP_000708690.1\|767518_768229_+\|allophanate-hydrolase-subunit-1	unknown	unknown	gnl\|CDD\|224960
NZ_CP017090.1\|WP_000429006.1\|781340_782258_-\|lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NZ_CP017090.1\|WP_000098285.1\|769690_771631_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	unknown	unknown	gnl\|CDD\|224287
NZ_CP017090.1\|WP_000930014.1\|784373_784874_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl\|CDD\|223851
NZ_CP017090.1\|WP_001797134.1\|767224_767431_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000876318.1\|790490_791462_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226965
NZ_CP017090.1\|WP_000692521.1\|786560_786959_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	unknown	unknown	gnl\|CDD\|224694
NZ_CP017090.1\|WP_000589248.1\|775798_776776_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP017090.1\|WP_088401681.1\|784893_785760_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_000022323.1\|768212_769217_+\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	1.25641e-144
NZ_CP017090.1\|WP_000855514.1\|786921_789027_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|236069	PRK07632, PRK07632, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NZ_CP017090.1\|WP_000180991.1\|776768_778283_+\|ABC-transporter-permease/substrate-binding-protein	gnl\|CDD\|270328	cd13610, PBP2_ChoS, Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold. Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.03165e-152
NZ_CP017090.1\|WP_000193751.1\|782527_784033_-\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	1.22605e-172
NZ_CP017090.1\|WP_000983677.1\|773795_775577_+\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP017090.1\|WP_000663030.1\|778522_779581_+\|histidinol-phosphate-transaminase	gnl\|CDD\|235106	PRK03158, PRK03158, histidinol-phosphate aminotransferase; Provisional.	0
NZ_CP017090.1\|WP_000562498.1\|789144_790116_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	2.30551e-164
NZ_CP017090.1\|WP_000197262.1\|779919_780462_+\|5'-3'-deoxyribonucleotidase	gnl\|CDD\|226895	COG4502, COG4502, 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism].	3.14113e-108
NZ_CP017090.1\|WP_088401681.1\|784893_785760_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.77531e-10
NZ_CP017090.1\|WP_000525106.1\|771900_773784_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NZ_CP017090.1\|WP_000708690.1\|767518_768229_+\|allophanate-hydrolase-subunit-1	gnl\|CDD\|224960	COG2049, DUR1, Allophanate hydrolase subunit 1 [Amino acid transport and metabolism].	1.34598e-94
NZ_CP017090.1\|WP_000429006.1\|781340_782258_-\|lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	7.55646e-79
NZ_CP017090.1\|WP_000098285.1\|769690_771631_+\|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NZ_CP017090.1\|WP_000930014.1\|784373_784874_-\|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl\|CDD\|223851	COG0780, COG0780, Enzyme related to GTP cyclohydrolase I [General function prediction only].	7.91282e-79
NZ_CP017090.1\|WP_000876318.1\|790490_791462_+\|ABC-transporter-permease	gnl\|CDD\|226965	COG4606, CeuB, ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism].	1.32603e-150
NZ_CP017090.1\|WP_000692521.1\|786560_786959_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	gnl\|CDD\|224694	COG1780, NrdI, Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism].	5.52807e-56
NZ_CP017090.1\|WP_000589248.1\|775798_776776_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.28246e-155

>NZ_CP017090.1|WP_000197262.1|779919_780462_+|5'-3'-deoxyribonucleotidase
MTRKSIAIDMDEVLADTLGEIIDAVNFRADLGIKMEALNGQKLKHVIPEHDGLITEVLREPGFFRHLKVMPHAQEVVKKLTEHYDVYIATAAMDVPTSFSDKYEWLLEFFPFLDPQHFVFCGRKNIVKADYLIDDNPRQLEIFTGTPIMFTAVHNINDDRFERVNSWKDVEQYFLDNIEK
>NZ_CP017090.1|WP_000663030.1|778522_779581_+|histidinol-phosphate-transaminase
MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE
>NZ_CP017090.1|WP_000180991.1|776768_778283_+|ABC-transporter-permease/substrate-binding-protein
MTNFFDILSERKGQLFSTMIEHIQISFIALLIATAIAVPLGILLTKTKTISEIVMNIAAILQTIPSLALLGLMIPLFGIGRVPAIIALVVYALLPILRNTYTGIKEVDPSLIEAAKGIGMKPFRRLTKVELPIAMPVIMAGVRTAMVLIIGTATLAALIGAGGLGDLILLGIDRNNASLILLGAIPAALLAIIFDLILRFMAKLSYKKLLMTLGVIVMIIILAIAIPMFAQKGDKITLAGKLGSEPSIITNMYKILIEEETKNTVEVKDGMGKTAFLFNALKSDDIDGYLEFTGTVLGELTKEPLKSKEEKKVYEQAKQSLEKKYQMTMLKPMKYNNTYALAVKRDFAKQHNIRTIGDLNKVKDQLKPGFTLEFNDRPDGYKAVQKAYNLNLDNIRTMEPKLRYQAINKGNINLIDAYSTDAELKQYDMVVLKDDKHVFPPYQGAPLFKESFLKKHPEIKKPLNKLENKISDEDMQMMNYKVTVKNEDPYTVAKDYLKAKGLIK
>NZ_CP017090.1|WP_000589248.1|775798_776776_+|ABC-transporter-ATP-binding-protein
MIKFKNVTKRYGKHVAVDNISFNINEGEFFVLIGPSGCGKTTTLKMINRLIHLSEGYIYFKDKPISDYPVYEMRWDIGYVLQQIALFPHMTIKENIAQVPQMKKWKEKDIDKRVDELLDMVGLEPEKYKNRKPDELSGGQRQRVGVIRALAADPPVILMDEPFSALDPISREKLQDDLIELQTKIKKTIIFVTHDIQEAMKLGDKICLLNEGHIEQIDTPEGFKNNPQSEFVKQFMGSHLEDDAPCVEENAIIRDLDIMKPIDEVTSMSAYPIVYDNQPIEVLYQHLSESERVIVMQEDSVGQYVIDRKDIFKYLSQKKEVAQHD
>NZ_CP017090.1|WP_000983677.1|773795_775577_+|DNA-helicase-RecQ
MMQQTLSHYFGYETFRPGQEEIISKVLDHRNVLGVLPTGGGKSICYQVPGLLLGGTTIVISPLISLMKDQVDQLKAMGIQAAFLNSSLTQKEQQRIEKALSNGEIQFLYVAPERFENRYFLNMLQRIKIHLVAFDEAHCISKWGHDFRPSYQNVISKVFTLPQDFTIIALTATATVEVQQDIREKLNIAQTDQIKTSTKRRNLIFKVNPTYQRQKFILDYIKTHDEDAGIIYCSTRKQVEELQEALESQKIESVIYHAGLSNKEREEAQNDFLFDRVKVVVATNAFGMGIDKSNVRFVIHYNMPGDLESYYQEAGRAGRDGLKSECILLFSERDINLHEYFITVSQADDDYKDKMGEKLTKMIQYTKTKKCLEATIVHYFEPNEKLEECEQCSNCVQQDKSYNMTQEAKMIISCIARMKQQESYSVIIQVLRGESTDYIKYKGYDQISTHGLMKGYTTSELSHLIDELRFKGFLNENDEILMCDTSIKKLLSNEVEVFTTPFKQKATEKVFINTVEGVDRVLFSQLVEVRKKLSDKLTIAPVSIFSDYTLEEFAKRKPASKQDMINIDGVGSYKLKHYCPAFLETIQNYKAKV
>NZ_CP017090.1|WP_000525106.1|771900_773784_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MGMEAYKIEHLNKSYADKTIFDNLDLSISEGEKIGLVGINGTGKSTLLKVIGGIDDDFTANVMHPNQYRIRYSSQKQDLNEDMTVFDAVLSSDTTTLRIIKQYEQAVQAYADDQSDKLFKRMIDAQDAMDQHDAWDYNAEIKTILSKLGIHDTTKYIKELSGGQQKRVVLAKTLIEQPDLLLLDEPTNHLDFESISWLINYVKQYPHTVLFVTHDRYFLNEVSTRIIELNRGKLASYPGNYESYIEMRAEREVTLQKQQQKQRALYKEELAWMRAGAKARTTKQQARINRFNDLENEVNQQYKDDKGELNLAYSRLGKQVFELEDLSKAINDKVLFEHLTEIIQKGERIGVVGPNGAGKTTLLNILSGEDQQFEGKLKTGQTVKVAYFKQTDETLDRDIRMIDYLREESEVAKEKDGTSVSITQLLERFLFPSATHGKKVYKLSGGEQKRLYLLRLLVHQPNVLLLDEPTNDLDTETLTILEDYIHTFGGTVITVSHDRYFLNKVAQSYWFIHDGQMEKIIGTFEDYESYKKSLDKNKSTLKQQSKSYTTVRKKNGLSYKEKLEYEQLMKRIEQAEVRMEEIDVLMIEASADYGKIKELNEEKEQLEIQYDLDITRWSELEEIKEQQ
>NZ_CP017090.1|WP_000098285.1|769690_771631_+|polyglycerol-phosphate-lipoteichoic-acid-synthase-LtaS
MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
>NZ_CP017090.1|WP_000022323.1|768212_769217_+|biotin-dependent-carboxyltransferase-family-protein
MSIIIEKSGLFSSFQDFGRRGYEHDGVIPCGALDTLAHEIANRLVANDKNEATLEMTNKMATIRFTEPTLIALAGGNVKAYTEHMTISPYKLYLLDKGDVLKFRETSYTSRVYLAVGGGFELDAWLGSNSTDFNVKIGGFKGRTLQDGDEIKLKRDYTARHHKLFENLAHTKQTDWGIDGYALSFNYMSDVFHVVKNKGTEDFKEDAIQRFVKHDYKVTSKANRMGMMLEGEKIKAFYEDMPPYQTVKKGTIQIKRDGTPIILLNDHYTLGSYPQIGTIASYHLTKLAQKPQGSRLKFQFIDILTAEKNLVKYSNWLNQLFHGIEYRMQLEMMK
>NZ_CP017090.1|WP_000708690.1|767518_768229_+|allophanate-hydrolase-subunit-1
MKIYSQGDQAIVVAIEKEVSKSLTEDLLTLRSYLIEQNYPFIIEIVPSESDMMIVYDARDMIKHHNIQSPFLYMKALIESIHLNIKHDFNQQDLIEIPIVYGSKYGPDIESLLKHYKIKLETFIELHSKTQYFVSMMGYSPGFPYLTGLNKKLYINHTSKQKKFIPAGSVVLEGKKCGIVTTDTINDWLVIGYTPLSLFNPKESDFARLKLGDNIKFRPINENELEVGAFKDVNHN
>NZ_CP017090.1|WP_001797134.1|767224_767431_+|hypothetical-protein
MIIVYIVLLLILVYVNYRLVNRLLSENRIYVVRLIVTITTVISFILVYALIHELMPFVVRAMDLMYHQ
>NZ_CP017090.1|WP_000429006.1|781340_782258_-|lipid-kinase
MENKYTHGVLFYHEHSGLKNINQGIGEVTTALSSICKHLSIQLSENEGDIIKYCQEIKTKNYAKDVDILFILGGDGTVNELINGVMSHDLQLPIGILPGGTFNDFTKTLNIAPNHKQASEQMISAQVGTYDVIKINNQYALNFVGLGLIVQNAENVQDGSKDIFGKLSYIGSTVKTLLNPTQFNYQLSIDDKTYSGETTMILTANGPFIGGSRIPLTDLSPQDGELNTFIFNEQSFSILNDIFKKRDSMNWNEITQGIEHIPGKKISLTTDPAMKVDIDGEISLETPIDIEVIPNAIQLLTVNDL
>NZ_CP017090.1|WP_031760357.1|782348_782450_+|hypothetical-protein
MVITDIDVYRVGRENIVIAVYNEHIKLLFILIS
>NZ_CP017090.1|WP_000193751.1|782527_784033_-|peptide-MFS-transporter
MTQQNSHGNQIQDIPQTGFFGHPRGLGVLFFVEFWERFSYYGMRALLIFYMYFAVTDNGLGIDKTTAMSIMSVYGSLIYMTSIPGGWIADRITGTRGATLLGAVFIIIGHICLSLPFALIGLFTSMFFIIIGSGLMKPNISNIVGRLYPENDRRMDAGFVIFYMSVNMGALLSPIILQHFVNVKNFHGGFLIAAVGMALGLVWYVLFNRKNLGSVGMKPTNPLTPAEKKKYGLIIGSVVLAIVLIIVIGALTNSLSFNLVSNTVLVLGIALPIIYFTLIIRSKDVTDTERSRVKAFIPLFILGMVFWAIQEQGSNVLNIYGIEHSDMKLNLFGWKTNFGEAIFQSINPLFILLLAPIISLLWQKLGTKQPSLPVKFAIGTFLAGASYILIGIVGYASGSSNFSVNWVILSYIICVIGELCLSPTGNSAAVKLAPKAFNAQMMSIWYLTNASAQAINGTLVKLIEPLGQTNYFIFLGVVAIIVTTIVLAFSPLIIKAMKGIR
>NZ_CP017090.1|WP_000930014.1|784373_784874_-|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
>NZ_CP017090.1|WP_088401681.1|784893_785760_-|DMT-family-transporter
MNPKAKGIIAILISAIGFSFMSVFFRLAGDLPVFQKSLARNLVAMFIPLFFLYKYHQPMFGRLSSQPLLITRSTLGLIGVLLNIYAIDHMVLSDADSLMKLNPFWTILLSIVFLHEKVRKYQITAMIIAILGMLLIVKPEFSSSMIPSLAGLFSGIFAASAYTCVRALSSREAPYTIVFYFSLFSVIVLIPFTAYTYEPMSQMQILYLLGAGLAAAVGQIGVTLAYSFAAAKDISIFTYASIIFTAILGFVLFGESPDFYATLGYVVIIGASYYMFEKARRDAKIIKK
>NZ_CP017090.1|WP_000692521.1|786560_786959_+|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI
MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
>NZ_CP017090.1|WP_000855514.1|786921_789027_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MKTMEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITDYAKSISFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRARRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQRPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKYYDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDEIKRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESEEAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQQDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIATIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
>NZ_CP017090.1|WP_000562498.1|789144_790116_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MIAVNWNTQEDMTNMFWRQNISQMWVETEFKVSKDIASWKTLSEAEQDTFKKALAGLTGLDTHQADDGMPLVMLHTTDLRKKAVYSFMAMMEQIHAKSYSHIFTTLLPSSETNYLLDEWVLEEPHLKYKSDKIVANYHKLWGKEASIYDQYMARVTSVFLETFLFFSGFYYPLYLAGQGKMTTSGEIIRKILLDESIHGVFTGLDAQHLRNELSESEKQKADQEMYKLLNDLYLNEESYTKMLYDDLGITEDVLNYVKYNGNKALSNLGFEPYFEEREFNPIIENALDTTTKNHDFFSVKGDGYVLALNVEALQDDDFVFDNK
>NZ_CP017090.1|WP_000499195.1|790296_790452_+|hypothetical-protein
MFYFTLSKQNTHSEKLNFSLIANINKIDTKLFERLLKLWSKNATINEKYYQ
>NZ_CP017090.1|WP_000876318.1|790490_791462_+|ABC-transporter-permease
MKYLLKGNILLLLLILLTIISLFIGVSELSIKDLLHLTESQRNILFSSRIPRTMSILIAGSSLALAGLIMQQMMQNKFVSPTTAGTMEWAKLGILIALLFFPTGHILLKLVFAVICSICGTFLFVKIIDFIKVKDVIFVPLLGIMMGGIVASFTTFISLRTNAVQSIGNWLNGNFAIITSGRYEILYLSIPLLALTYLFANHFTIVGMGKDFTNNLGLSYEKLINIALFITATITALVVVTVGTLPFLGLVIPNIISIYRGDHLKNAIPHTMMLGAIFVLFSDIVGRIVVYPYEINIGLTIGVFGTIIFLILLMKGRKNYAQQ

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Crispr_ID: NZ_CP017090_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_3

823078-823156

Unclear

Consensus_repeat	Method
TGTAGAATTTCTTTTCGAAATTCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_3

>merge|NZ_CP017090|3|823078-823156|CRISPRCasFinder
TGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCGCCAACTTGCATTGCCTGTAGAATTTCTTTTCGAAATTCT

>NZ_CP017090|3|3|823078-823156|CRISPRCasFinder
TGTAGAATTTCTTTTCGAAATTCT	CTGTGTTGGGGCCCCGCCAACTTGCATTGCC
TGTAGAATTTCTTTTCGAAATTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_000958224.1\|823414_824347_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP017090.1\|WP_000513305.1\|824352_825192_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP017090.1\|WP_000229241.1\|817911_819897_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP017090.1\|WP_000006551.1\|830916_831861_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP017090.1\|WP_000538141.1\|816759_817410_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NZ_CP017090.1\|WP_000506531.1\|811381_813913_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP017090.1\|WP_001790092.1\|813954_814059_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_001792175.1\|815491_815599_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_001224793.1\|825199_825685_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP017090.1\|WP_001248939.1\|829810_830806_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP017090.1\|WP_000638419.1\|817406_817643_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NZ_CP017090.1\|WP_088401683.1\|828902_829814_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP017090.1\|WP_000753319.1\|815746_816586_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP017090.1\|WP_010956549.1\|814227_815338_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP017090.1\|WP_000057543.1\|825692_827132_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP017090.1\|WP_000134963.1\|827198_828134_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP017090.1\|WP_000617735.1\|810395_810968_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NZ_CP017090.1\|WP_000816304.1\|833254_834157_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP017090.1\|WP_001049165.1\|832424_833012_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP017090.1\|WP_000662677.1\|819904_822751_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_000958224.1\|823414_824347_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NZ_CP017090.1\|WP_000513305.1\|824352_825192_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.75588e-120
NZ_CP017090.1\|WP_000229241.1\|817911_819897_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP017090.1\|WP_000006551.1\|830916_831861_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP017090.1\|WP_000538141.1\|816759_817410_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NZ_CP017090.1\|WP_000506531.1\|811381_813913_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP017090.1\|WP_000057543.1\|825692_827132_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
NZ_CP017090.1\|WP_001224793.1\|825199_825685_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NZ_CP017090.1\|WP_001248939.1\|829810_830806_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP017090.1\|WP_000638419.1\|817406_817643_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NZ_CP017090.1\|WP_088401683.1\|828902_829814_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	1.10755e-169
NZ_CP017090.1\|WP_000753319.1\|815746_816586_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.97111e-42
NZ_CP017090.1\|WP_010956549.1\|814227_815338_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP017090.1\|WP_000134963.1\|827198_828134_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP017090.1\|WP_000617735.1\|810395_810968_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NZ_CP017090.1\|WP_000816304.1\|833254_834157_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
NZ_CP017090.1\|WP_001049165.1\|832424_833012_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP017090.1\|WP_000662677.1\|819904_822751_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0

>NZ_CP017090.1|WP_000662677.1|819904_822751_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIDVPEYRRPASDRKISIRGARSNNLKGIDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NZ_CP017090.1|WP_000229241.1|817911_819897_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVDGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NZ_CP017090.1|WP_000638419.1|817406_817643_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NZ_CP017090.1|WP_000538141.1|816759_817410_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NZ_CP017090.1|WP_000753319.1|815746_816586_+|CHAP-domain-containing-protein
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NZ_CP017090.1|WP_001792175.1|815491_815599_+|hypothetical-protein
MCLLKQHMQCAFSNITYGDFQGIELIVENVLNYMV
>NZ_CP017090.1|WP_010956549.1|814227_815338_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NZ_CP017090.1|WP_001790092.1|813954_814059_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>NZ_CP017090.1|WP_000506531.1|811381_813913_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NZ_CP017090.1|WP_000617735.1|810395_810968_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NZ_CP017090.1|WP_000958224.1|823414_824347_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NZ_CP017090.1|WP_000513305.1|824352_825192_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NZ_CP017090.1|WP_001224793.1|825199_825685_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP017090.1|WP_000057543.1|825692_827132_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP017090.1|WP_000134963.1|827198_828134_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP017090.1|WP_088401683.1|828902_829814_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFESFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP017090.1|WP_001248939.1|829810_830806_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP017090.1|WP_000006551.1|830916_831861_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP017090.1|WP_001049165.1|832424_833012_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP017090.1|WP_000816304.1|833254_834157_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE

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Crispr_ID: NZ_CP017090_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_4

835730-835809

Orphan

Consensus_repeat	Method
CAGCTTCTGTGTTGGGGCCCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_4

>merge|NZ_CP017090|4|835730-835809|CRISPRCasFinder
CAGCTTCTGTGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCCGCCAGCTTCTGTGTTGGGGCCCCACC

>NZ_CP017090|4|4|835730-835809|CRISPRCasFinder
CAGCTTCTGTGTTGGGGCCCCGCC	AACTTGCACATTATTGTAAGCTGACTTTCCGC
CAGCTTCTGTGTTGGGGCCCCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_000513305.1\|824352_825192_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP017090.1\|WP_001260089.1\|839772_840534_+\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NZ_CP017090.1\|WP_001165959.1\|844700_845441_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224561
NZ_CP017090.1\|WP_000279414.1\|837311_838322_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CP017090.1\|WP_000785252.1\|843826_844285_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000006551.1\|830916_831861_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP017090.1\|WP_000057543.1\|825692_827132_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP017090.1\|WP_001050048.1\|845474_847847_+\|ribonuclease-R	unknown	unknown	gnl\|CDD\|273947
NZ_CP017090.1\|WP_001224793.1\|825199_825685_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP017090.1\|WP_000654030.1\|836245_837259_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP017090.1\|WP_000556760.1\|844351_844585_+\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|224233
NZ_CP017090.1\|WP_001248939.1\|829810_830806_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP017090.1\|WP_001085505.1\|840536_842054_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|235463
NZ_CP017090.1\|WP_088401683.1\|828902_829814_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP017090.1\|WP_001121760.1\|842183_843488_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP017090.1\|WP_000134963.1\|827198_828134_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP017090.1\|WP_000816304.1\|833254_834157_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP017090.1\|WP_001049165.1\|832424_833012_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP017090.1\|WP_000070831.1\|834859_835489_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NZ_CP017090.1\|WP_001074749.1\|838460_839651_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_000513305.1\|824352_825192_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.75588e-120
NZ_CP017090.1\|WP_001260089.1\|839772_840534_+\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	2.84083e-146
NZ_CP017090.1\|WP_001165959.1\|844700_845441_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	1.30175e-132
NZ_CP017090.1\|WP_000279414.1\|837311_838322_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP017090.1\|WP_000006551.1\|830916_831861_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP017090.1\|WP_000057543.1\|825692_827132_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
NZ_CP017090.1\|WP_001050048.1\|845474_847847_+\|ribonuclease-R	gnl\|CDD\|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NZ_CP017090.1\|WP_001224793.1\|825199_825685_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NZ_CP017090.1\|WP_000654030.1\|836245_837259_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NZ_CP017090.1\|WP_000556760.1\|844351_844585_+\|preprotein-translocase-subunit-SecG	gnl\|CDD\|224233	COG1314, SecG, Preprotein translocase subunit SecG [Intracellular trafficking and secretion].	6.41939e-15
NZ_CP017090.1\|WP_001248939.1\|829810_830806_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP017090.1\|WP_001085505.1\|840536_842054_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|235463	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0
NZ_CP017090.1\|WP_088401683.1\|828902_829814_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	1.10755e-169
NZ_CP017090.1\|WP_001121760.1\|842183_843488_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP017090.1\|WP_000134963.1\|827198_828134_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP017090.1\|WP_000816304.1\|833254_834157_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
NZ_CP017090.1\|WP_001049165.1\|832424_833012_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP017090.1\|WP_000070831.1\|834859_835489_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.80381e-05
NZ_CP017090.1\|WP_001074749.1\|838460_839651_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0

>NZ_CP017090.1|WP_000070831.1|834859_835489_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDNASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NZ_CP017090.1|WP_000816304.1|833254_834157_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>NZ_CP017090.1|WP_001049165.1|832424_833012_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP017090.1|WP_000006551.1|830916_831861_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP017090.1|WP_001248939.1|829810_830806_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP017090.1|WP_088401683.1|828902_829814_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFESFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP017090.1|WP_000134963.1|827198_828134_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP017090.1|WP_000057543.1|825692_827132_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP017090.1|WP_001224793.1|825199_825685_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP017090.1|WP_000513305.1|824352_825192_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NZ_CP017090.1|WP_000654030.1|836245_837259_+|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NZ_CP017090.1|WP_000279414.1|837311_838322_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NZ_CP017090.1|WP_001074749.1|838460_839651_+|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>NZ_CP017090.1|WP_001260089.1|839772_840534_+|triose-phosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK
>NZ_CP017090.1|WP_001085505.1|840536_842054_+|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MAKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGLDVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNAIAHVNSHDSALHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDGRDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAYNAIRNFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVNDGDAVIFYNFRPDRAAQLSEIFANRAFEGFKVEQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQNNNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDECLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTKEGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH
>NZ_CP017090.1|WP_001121760.1|842183_843488_+|phosphopyruvate-hydratase
MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVENVNEIIAPEIIEGEFSVLDQVSIDKMMIALDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPVGATTFKESLRWGTEIFHNLKSILSKRGLETAVGDEGGFAPKFEGTEDAVETIIQAIEAAGYKPGEEVFLGFDCASSEFYENGVYDYSKFEGEHGAKRTAAEQVDYLEQLVDKYPIITIEDGMDENDWDGWKQLTERIGDRVQLVGDDLFVTNTEILAKGIENGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKYDGIKSFYNLDK
>NZ_CP017090.1|WP_000785252.1|843826_844285_+|hypothetical-protein
MADRTNKEIKTGRFIATASIVFSILLIIHYFVSLDNATAKALLNLTNQNTSDKAIDYILNSFRFTGIMYILAYLAGFITFWNRHTYVWWFMFAVYVSNSLFTLINLSITIQAIKAAHGAYLTLPILIVIIGSVALAIYMLVVSIKRKSTFNR
>NZ_CP017090.1|WP_000556760.1|844351_844585_+|preprotein-translocase-subunit-SecG
MHTFLIVLLIIDCIALITVVLLQEGKSSGLSGAISGGAEQLFGKQKQRGVDLFLNRLTIILSILFFVLMICISYLGM
>NZ_CP017090.1|WP_001165959.1|844700_845441_+|prolyl-oligopeptidase-family-serine-peptidase
MQIKLPKPFFFEEGKRAVLLLHGFTGNSSDVRQLGRFLQKKGYTSYAPQYEGHAAPPEEILKSSPFVWFKDALDGYDYLVEQGYDEIVVAGLSLGGDFALKLSLNRDVKGIVTMCAPMGGKTEGAIYEGFLEYARNFKKYEGKNQETIDNEMDHFKPTETLKELSEALDTIKDQVDEVFDPILVIQVENDNMIDPQSANYIYDHVDSDDKDIKWYSQSGHVITIDKEKEQVFEDIYQFLESLDWSE
>NZ_CP017090.1|WP_001050048.1|845474_847847_+|ribonuclease-R
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSSKGHSKLIKGTLSQNKKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDDKRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVPDHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEDSALDKEAYDRATSVYLVDRVIPMIPHRLSNGICSLNPHVDRLTLSCRMEIDASGRVVKHEIFDSVIHSDYRMTYDAVNQIITEKDPNIREQYKEITPMLDLAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEVGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLNVPFIYRVHEQPKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFTSPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSSVANFGMFIELPNTIEGMVHIANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDRSQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKSVKKKARRKKK

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Crispr_ID: NZ_CP017090_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_5

871870-871951

Orphan

Consensus_repeat	Method
CCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_5

>merge|NZ_CP017090|5|871870-871951|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAAATTGAGAATCCAATTTCTCTTTGTTGGGGCCCATCCCCAACTTGCATTGCCTGTAGAA

>NZ_CP017090|5|5|871870-871951|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAA	ATTGAGAATCCAATTTCTCTTTGTTGGGGCCCAT
CCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_001183854.1\|876821_877673_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NZ_CP017090.1\|WP_000589549.1\|869814_870171_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NZ_CP017090.1\|WP_000290491.1\|870328_870709_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NZ_CP017090.1\|WP_000168845.1\|878000_878762_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP017090.1\|WP_000932225.1\|870887_871766_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NZ_CP017090.1\|WP_000752917.1\|876393_876588_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_CP017090.1\|WP_000974460.1\|867291_867714_-\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP017090.1\|WP_000662306.1\|870772_870886_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_001147952.1\|869350_869671_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP017090.1\|WP_000807663.1\|880281_881523_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP017090.1\|WP_000422908.1\|868660_869200_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NZ_CP017090.1\|WP_000732324.1\|875218_876040_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP017090.1\|WP_001065801.1\|872941_873238_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP017090.1\|WP_001018962.1\|872562_872949_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NZ_CP017090.1\|WP_000205567.1\|878859_880167_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_CP017090.1\|WP_000520231.1\|874505_875201_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP017090.1\|WP_000569884.1\|866398_866893_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
NZ_CP017090.1\|WP_000150011.1\|867861_868578_+\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NZ_CP017090.1\|WP_000255551.1\|865626_866244_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NZ_CP017090.1\|WP_000571213.1\|873487_874513_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_001183854.1\|876821_877673_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	7.67366e-77
NZ_CP017090.1\|WP_000589549.1\|869814_870171_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NZ_CP017090.1\|WP_000290491.1\|870328_870709_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	9.01516e-70
NZ_CP017090.1\|WP_000168845.1\|878000_878762_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NZ_CP017090.1\|WP_000932225.1\|870887_871766_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	3.13065e-77
NZ_CP017090.1\|WP_000752917.1\|876393_876588_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
NZ_CP017090.1\|WP_000974460.1\|867291_867714_-\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	5.58225e-61
NZ_CP017090.1\|WP_001147952.1\|869350_869671_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.4922e-24
NZ_CP017090.1\|WP_000807663.1\|880281_881523_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP017090.1\|WP_000422908.1\|868660_869200_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.10032e-49
NZ_CP017090.1\|WP_000732324.1\|875218_876040_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	1.02861e-112
NZ_CP017090.1\|WP_001065801.1\|872941_873238_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	7.01368e-14
NZ_CP017090.1\|WP_001018962.1\|872562_872949_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	2.45102e-36
NZ_CP017090.1\|WP_000205567.1\|878859_880167_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	3.36148e-135
NZ_CP017090.1\|WP_000520231.1\|874505_875201_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	7.66296e-99
NZ_CP017090.1\|WP_000569884.1\|866398_866893_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47
NZ_CP017090.1\|WP_000150011.1\|867861_868578_+\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	3.2619e-146
NZ_CP017090.1\|WP_000255551.1\|865626_866244_-\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	2.60719e-61
NZ_CP017090.1\|WP_000571213.1\|873487_874513_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.03316e-170

>NZ_CP017090.1|WP_000932225.1|870887_871766_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLSQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLNDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLENIQVHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NZ_CP017090.1|WP_000662306.1|870772_870886_+|hypothetical-protein
MKENLLGTIIWSIATFYYSRMMKIMNLAILKIKIGGS
>NZ_CP017090.1|WP_000290491.1|870328_870709_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQLEALLTAEKYSEMIGE
>NZ_CP017090.1|WP_000589549.1|869814_870171_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NZ_CP017090.1|WP_001147952.1|869350_869671_-|thioredoxin-family-protein
MQAIKSNESFKSIINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NZ_CP017090.1|WP_000422908.1|868660_869200_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>NZ_CP017090.1|WP_000150011.1|867861_868578_+|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFINDLYLNLISDLANINGIDMIDIEWQADIDIEKHQRIIKHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
>NZ_CP017090.1|WP_000974460.1|867291_867714_-|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NZ_CP017090.1|WP_000569884.1|866398_866893_-|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NZ_CP017090.1|WP_000255551.1|865626_866244_-|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLLIIIAVVGVSIIIMSLPVLQAIIYIVGLIFLMYMAWTIWHDKPSTDGEAQIISPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF
>NZ_CP017090.1|WP_001018962.1|872562_872949_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPLLPNINNERLVLVNE
>NZ_CP017090.1|WP_001065801.1|872941_873238_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFKSVTDLLENLK
>NZ_CP017090.1|WP_000571213.1|873487_874513_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHTVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NZ_CP017090.1|WP_000520231.1|874505_875201_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWIVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NZ_CP017090.1|WP_000732324.1|875218_876040_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGNKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYDLDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGDVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NZ_CP017090.1|WP_000752917.1|876393_876588_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NZ_CP017090.1|WP_001183854.1|876821_877673_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNGDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEVVKLNFTGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NZ_CP017090.1|WP_000168845.1|878000_878762_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NZ_CP017090.1|WP_000205567.1|878859_880167_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKHFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDKNASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NZ_CP017090.1|WP_000807663.1|880281_881523_+|cysteine-desulfurase
MAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPMQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSAIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF

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Crispr_ID: NZ_CP017090_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_6

1703254-1703338

Orphan

Consensus_repeat	Method
CACCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_6

>merge|NZ_CP017090|6|1703254-1703338|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAAATTGGGAATCCAATTTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTGCCTGTAGAA

>NZ_CP017090|6|6|1703254-1703338|CRISPRCasFinder
CACCCCAACTTGCATTGTCTGTAGAA	ATTGGGAATCCAATTTCTCTGTGTTGGGGCCCA
CACCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_001802667.1\|1692463_1693147_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223961
NZ_CP017090.1\|WP_000725167.1\|1712138_1712708_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|273101
NZ_CP017090.1\|WP_000627144.1\|1700742_1701720_-\|heat-inducible-transcription-repressor-HrcA	unknown	unknown	gnl\|CDD\|273017
NZ_CP017090.1\|WP_000182211.1\|1700084_1700711_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237622
NZ_CP017090.1\|WP_001104607.1\|1695966_1696905_-\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|283886
NZ_CP017090.1\|WP_000439693.1\|1709212_1709674_-\|ComE-operon-protein-2	unknown	unknown	gnl\|CDD\|131622
NZ_CP017090.1\|WP_001274017.1\|1705679_1705931_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|178943
NZ_CP017090.1\|WP_000953309.1\|1707006_1709154_-\|DNA-internalization-related-competence-protein-ComEC/Rec2	unknown	unknown	gnl\|CDD\|225212
NZ_CP017090.1\|WP_001119021.1\|1696908_1698048_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237656
NZ_CP017090.1\|WP_000048060.1\|1693390_1693567_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NZ_CP017090.1\|WP_000368338.1\|1703510_1705334_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP017090.1\|WP_001190120.1\|1695212_1695965_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|224303
NZ_CP017090.1\|WP_000218103.1\|1701820_1702945_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_CP017090.1\|WP_001282563.1\|1705975_1706950_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|235511
NZ_CP017090.1\|WP_001019324.1\|1711564_1712149_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224627
NZ_CP017090.1\|WP_000108667.1\|1693859_1695206_-\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	unknown	unknown	gnl\|CDD\|223694
NZ_CP017090.1\|WP_088401715.1\|1698183_1700016_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP017090.1\|WP_000084830.1\|1710491_1711208_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP017090.1\|WP_001802022.1\|1709765_1710452_-\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472
NZ_CP017090.1\|WP_001088020.1\|1711210_1711564_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|223870

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_001802667.1\|1692463_1693147_-\|hypothetical-protein	gnl\|CDD\|223961	COG1030, NfeD, Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones].	8.78003e-63
NZ_CP017090.1\|WP_000725167.1\|1712138_1712708_-\|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase	gnl\|CDD\|273101	TIGR00482, Probable_nicotinate-nucleotide_adenylyltransferase, nicotinate (nicotinamide) nucleotide adenylyltransferase. This model represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides].	2.64141e-76
NZ_CP017090.1\|WP_000627144.1\|1700742_1701720_-\|heat-inducible-transcription-repressor-HrcA	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	2.05887e-119
NZ_CP017090.1\|WP_000182211.1\|1700084_1700711_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237622	PRK14140, PRK14140, heat shock protein GrpE; Provisional.	3.74407e-81
NZ_CP017090.1\|WP_001104607.1\|1695966_1696905_-\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|283886	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	9.7051e-134
NZ_CP017090.1\|WP_000439693.1\|1709212_1709674_-\|ComE-operon-protein-2	gnl\|CDD\|131622	TIGR02571, putative_dCMP_deaminase, ComE operon protein 2. This protein is found in the ComE operon for "late competence" as characterized in B. subtilis. Proteins in this family contain homology to a cytidine/deoxycytidine deaminase domain family (pfam00383), and may carry out this activity.	4.81051e-102
NZ_CP017090.1\|WP_001274017.1\|1705679_1705931_+\|30S-ribosomal-protein-S20	gnl\|CDD\|178943	PRK00239, rpsT, 30S ribosomal protein S20; Reviewed.	1.42889e-17
NZ_CP017090.1\|WP_000953309.1\|1707006_1709154_-\|DNA-internalization-related-competence-protein-ComEC/Rec2	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	1.49563e-90
NZ_CP017090.1\|WP_001119021.1\|1696908_1698048_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237656	PRK14280, PRK14280, molecular chaperone DnaJ.	0
NZ_CP017090.1\|WP_000048060.1\|1693390_1693567_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	1.15423e-10
NZ_CP017090.1\|WP_000368338.1\|1703510_1705334_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP017090.1\|WP_001190120.1\|1695212_1695965_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|224303	COG1385, COG1385, Uncharacterized protein conserved in bacteria [Function unknown].	1.90273e-91
NZ_CP017090.1\|WP_000218103.1\|1701820_1702945_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_CP017090.1\|WP_001282563.1\|1705975_1706950_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	4.1415e-104
NZ_CP017090.1\|WP_001019324.1\|1711564_1712149_-\|HD-domain-containing-protein	gnl\|CDD\|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	2.21948e-80
NZ_CP017090.1\|WP_000108667.1\|1693859_1695206_-\|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	0
NZ_CP017090.1\|WP_088401715.1\|1698183_1700016_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP017090.1\|WP_000084830.1\|1710491_1711208_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.79783e-16
NZ_CP017090.1\|WP_001802022.1\|1709765_1710452_-\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	1.06297e-33
NZ_CP017090.1\|WP_001088020.1\|1711210_1711564_-\|ribosome-silencing-factor	gnl\|CDD\|223870	COG0799, COG0799, Uncharacterized homolog of plant Iojap protein [Function unknown].	5.95861e-47

>NZ_CP017090.1|WP_000218103.1|1701820_1702945_-|oxygen-independent-coproporphyrinogen-III-oxidase
MTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRNLKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVNRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDAIALTKRGKVIGNEVFEAFLIND
>NZ_CP017090.1|WP_000627144.1|1700742_1701720_-|heat-inducible-transcription-repressor-HrcA
MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFSNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLINTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
>NZ_CP017090.1|WP_000182211.1|1700084_1700711_-|nucleotide-exchange-factor-GrpE
MTNKDESVEKNTESTVEETNIKQNIDDSVEQAEESKGHLQDEAIEETSDENVIEEIDPKDQKINELQQLADENEEKYLRLYAEFENYKRRIQKENEINKTYQAQRVLTDILPAIDNIERALQIEGDDETFKSLQKGVQMVHESLINALKDNGLEVIKTEGEAFDPNIHQAVVQDDNPDFESGEITQELQKGYKLKDRVLRPSMVKVNQ
>NZ_CP017090.1|WP_088401715.1|1698183_1700016_-|molecular-chaperone-DnaK
MSKIIGIDLGTTNSCVTVLEGDEPKVIQNPEGSRTTPSVVAFKNGETQVGEVAKRQAITNPNTVQSIKRHMGTDYKVDIEGKSYTPQEISAMILQNLKNTAESYLGEKVDKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDKDEKVLVFDLGGGTFDVSILELGDGVFEVLSTAGDNKLGGDDFDQVIIDYLVAEFKKENGVDLSQDKMALQRLKDAAEKAKKDLSGVSQTQISLPFISAGENGPLHLEVNLTRSKFEELSDSLIRRTMEPTRQAMKDAGLTNSDIDEVILVGGSTRIPAVQEAVKKEIGKEPNKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIEILGGRMNTLIERNTTIPTSKSQIYSTAVDNQPSVDVHVLQGERPMAADNKTLGRFQLTDIPPAERGKPQIEVTFDIDKNGIVNVTAKDLGTNKEQRITIQSSSSLSDEEIDRMVKDAEVNAEADKKRREEVDLRNESDSLVFQVEKTLTDLGENIGEEDKKSAEEKKDALKTALEGQDIEDIKSKKEELEKVIQELSAKVYEQAAQQQQQAQGANAGQNNDSTVEDAEFKEVKDDDKK
>NZ_CP017090.1|WP_001119021.1|1696908_1698048_-|molecular-chaperone-DnaJ
MAKRDYYEVLGISKDASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDNKRASYDQFGHDGPQGFGGQGFNGSDFGGFSGFGGGGFEDIFSSFFGGGRQRDPNAPQKGDDLQYTMTLTFEEAVFGTTKEISIRKDVTCETCHGDGAKPGTSKKTCSYCNGAGHVAVEQNTILGRVRTEQVCPKCNGSGQEFEEACPTCHGKGTENKTVKLEVKVPEGVDNEQQIRLAGEGSPGVNGGPAGDLYVVFRVKPSETFKRDGDDIYYKLNVSFPQAALGDEIKIPTLNNEVMLTIPAGTQTGKQFRLKEKGIKNVHGYGYGDLYVDIKVVTPTKLTDRQKELMKEFAQLNGEEINEQPSNFKDRAKRFFKGE
>NZ_CP017090.1|WP_001104607.1|1695966_1696905_-|50S-ribosomal-protein-L11-methyltransferase
MNWTELSIIINHEAVELATNILENHGSNGVVIEDSDDLINQPEDKYGEIYALKKEDYPDKGVRLKAYFNEMTYDDKLRQQIKDELLNLDELDQHNIQFSEQIIAETDWENEWKNYFHPFRASKKFTIVPSWETYAKEADEELCIELDPGMAFGTGDHPTTSMCLKAIETYVLPQHSVIDVGTGSGILSIASHLIGVKRIKALDIDEMAVSVAKENFRRNHCETLIEAVPGNLLKDETEKFDIVIANILAHIIDEMIEDAYNTLNEGGYFITSGIIKEKYEGIQSHMERVGFKIISEQHDNGWVCLVGQKVSE
>NZ_CP017090.1|WP_001190120.1|1695212_1695965_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MQRYFIDQNADVSQRFFITKKEDIHHITNVMRYDVGSKIILTFNDQTVYLCEIADITSDKIAVDLKEKQNINTELPVDVTICSGLIKADKYEWLLQKATELGASSFIAVSMERSIVKLNEAKVVKKIERWQKIIKEAAEQSYRLVIPSIQFESNLKLICDTIDNYDYILIAYEEEAKDGELSNFKQTLQQFKAQDKVLMIFGPEGGLSENEISLFSNTSTVVGLGPRILRAETAPLYALSAISYEKELMG
>NZ_CP017090.1|WP_000108667.1|1693859_1695206_-|tRNA-(N(6)-L-threonylcarbamoyladenosine(37)-C(2))--methylthiotransferase-MtaB
MSTVAFHTLGCKVNHYETEAIWQLFKEANYERVDFEANADVFVINTCTVTNTGDKKSRQIIRRAIRQNPDAVICVTGCYAQTSSAEIMEIPGVDVVVGTQDRHKLLGYIDEFRKERQPINGVGNIMKNRKYEELDVPYFTDRTRASLKIQEGCNNFCTFCIIPWARGLMRSRDPEKVVEQATQLVNSGYKEIVLTGIHTGGYGQDLKDYNLAQLLRDLETINGLERIRISSIEASQLTDEVIDVLERSTKVVRHLHIPLQSGSDTVLKRMRRKYTMDRFSERLTKLHKALPDLAVTSDVIVGFPGETEAEFQETYDFIVKHKFSELHVFPYSPRIGTPAARMDDQIDEEIKNERVHKLITLSNQLGKLYASKFDQDVLEVIPEEQGDTEGTLVGYADNYMKVQFEGDESLIGQIVKVKITQANYPLNEGQAIKVVDFATNKSDREVLV
>NZ_CP017090.1|WP_000048060.1|1693390_1693567_-|30S-ribosomal-protein-S21
MSKTVVRKNESLEDALRRFKRSVSKSGTIQEVRKREFYEKPSVKRKKKSEAARKRKFK
>NZ_CP017090.1|WP_001802667.1|1692463_1693147_-|hypothetical-protein
MTTILESTAGDTWVEQVSNIIVQPIFTLILTCLTFLGFVYQLYSKKINAAGIIATLSLLILFLGFLIQGNVNMHSILIFSIGVILVVIELFVVGAVIGIIGMILITISITTLGDNLLFMLANVIVALILTIVEWVILVKIFNRKIPFLDKVILKDSTNSESGYNSHDNRSHLVGKTAQTVTDLRPAGIIFCENERIDAVSDGNFILRNKTVKILEVEGTRVVVREVD
>NZ_CP017090.1|WP_000368338.1|1703510_1705334_-|elongation-factor-4
MDNEQRLKRRENIRNFSIIAHIDHGKSTLADRILENTKSVETRDMQDQLLDSMDLERERGITIKLNAVRLKYEAKDGNTYTFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNELELLPVINKIDLPAAEPERVKQEIEDMIGLDQDDVVLASAKSNIGIEEILEKIVEVVPAPDGDPEAPLKALIFDSEYDPYRGVISSIRIVDGVVKAGDKIRMMATGKEFEVTEVGINTPKQLPVDELTVGDVGYIIASIKNVDDSRVGDTITLASRPASEPLQGYKKMNPMVYCGLFPIDNKNYNDLREALEKLQLNDASLEFEPESSQALGFGYRTGFLGMLHMEIIQERIEREFGIELIATAPSVIYQCILRDGSEVTVDNPAQMPDRDKIDKIFEPYVRATMMVPNDYVGAVMELCQRKRGQFINMDYLDDIRVNIVYELPLAEVVFDFFDQLKSNTKGYASFDYEFIENKESNLVKMDILLNGDKVDALSFIVHRDFAYERGKALVEKLKTLIPRQQFEVPVQAAIGQKIVARTNIKSMGKNVLAKCYGGDISRKRKLLEKQKAGKAKMKAVGNVEIPQDAFLAVLKMDDE
>NZ_CP017090.1|WP_001274017.1|1705679_1705931_+|30S-ribosomal-protein-S20
MANIKSAIKRVKTTEKAEARNISQKSAMRTAVKNAKTAVSNNADNKNELVSLAVKLVDKAAQSNLIHSNKADRIKSQLMTANK
>NZ_CP017090.1|WP_001282563.1|1705975_1706950_-|DNA-polymerase-III-subunit-delta
MSDNIVAIYGDVPELVEKQSAEIISQFLKSDRDDFNFVKYNLYETEIAPIVEETLTLPFFSDKKAILVKNAYIFTGEKAPKDMAHNVDQLIEFIEKYDGENLIVFEIYQNKLDERKKLTKTLKKHARLKKIEQMSEEEIKKWIQSKLNENFKDIKRDALDLFIELTGINFNIVSQEIEKLILFLGDRPTINKQDVNQIINRSLEQNVFLLTEYIQKRKKEQAIHLVKDLITMKEEPIKLLALITSNYRLFYQCKILSQKGYSGQQIAKTIGVHPYRVKLALGQVRHYQLDELLNIVDACAETDYKLKSSYMDKQLILELFILSL
>NZ_CP017090.1|WP_000953309.1|1707006_1709154_-|DNA-internalization-related-competence-protein-ComEC/Rec2
MLSTFLFILLLYITYRKNKIVYAPISLFLIIFSSWYLHYSQQAIFNYINYIERNSQFNERAQVIQIQRQGSDTYKGRLSLKNEIYPFFLTDKKNFDLKKIESRNCIVKGQFKVNENKFVTLKLQSIVVQSCLESNRSNLIEKHKQFIMNRIYDSGIKFPDRIMALITGDVKEINEQFKERVKEIGIYHLLAVSGSHIAAIVFLIYQPLKRLNLPLFVIKGITIIVLTLYAQYTNYAPSAVRAIIMTTLVLLITKQIKIKGIQLLAFAFIIMFILNPLVVYDIGFQFSFIISFFIMLLFPFLQQLSKLQSLFIITFIAQLASFIVAIPNFHQLQWVGFLSNLIFVPYYSIILFPLSILFFITSHFIVGLTPLNYLVDLSFNFHDWLLDLFTRIKQSHFSVPKFNDWIFIIFIISVYYIFWLLAKRKYILVTFWTIIILTLLITFPTNSHHKITMLNVGQGDSILYEGGKNQNVLIDTGGKVIDDTKQPSYSISKYHILPTLNERGINELEYLILTHPHNDHIGEVEYIISHIKIKHIVIYNKGYSSNTLMLLSKLSHKYNIKLMDVRQVSSFKLGDSSFLFFDSFIPNSRDKNEYSIITMITYQNKKVLLMGDASKNNESLLLKKYNLPEIDILKVGHHGSKTSSSKEFIEMIKPKISLISSGKNNMYHLPNIEVVKRLQRIRSRIYNSQQNGQVTIDLDDNLKVDSNSYGNASGL
>NZ_CP017090.1|WP_000439693.1|1709212_1709674_-|ComE-operon-protein-2
MERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEGCLIEDGHCIRTIHAEMNALLQCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAEDYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG
>NZ_CP017090.1|WP_001802022.1|1709765_1710452_-|ComEA-family-DNA-binding-protein
MVLLYQFLLRYKDFLTQWKLYIISAVVLIMVLIGFIFWRQDDYTSRNFENKDTALKQSTSENNSLSKLEDVQVKDGDNSKNKGPVYVDVKGAVKHPNVYKMTSKDRVVDLLDKAQLLDDADVSRINLSEKLTDQKMIFIPHKGQKNVEPQIEVNSVHVKNGNTNNTKVNLNTASVSELMSVPGVGQAKANAIVEYRNQQGAFQEIDDLKKVKGFGSKTFDKLKSYFTI
>NZ_CP017090.1|WP_000084830.1|1710491_1711208_-|class-I-SAM-dependent-methyltransferase
MSQYAEMSLVYDQLTQDQPYEKWFEIVKNHCKDESNILDIGCGTGSLTVQLEALGNVTGMDLSVDMLTVAAQKSANVNWLEGDMTSFDLQQQFDIITIFCDSLNYLQDETAVIETFINVYHHLTDSGVFIFDVHTVYKMMTLFNNQSYIDDKGDIFLAWDAVQGDLPLSVYHDMTFFIRHEDETYSRFDESHFQRTFDEKTYLSWLAQVGFKHVETFTDFNIDEHNEDTERLFFIAKK
>NZ_CP017090.1|WP_001088020.1|1711210_1711564_-|ribosome-silencing-factor
MNSQELLAIAVDAIDNKKGEDTISLEMKGISDMTDYFVVTHGNNERQVQAIARAVKEVANEQNIEVKRMEGYNEARWILIDLADVVVHVFHKDERNYYNIEKLYQDAPLESYGQVAY
>NZ_CP017090.1|WP_001019324.1|1711564_1712149_-|HD-domain-containing-protein
MNIEKAKRLAKEKLPEKRYNHSLRVAETAIKLAEIYDGDTSKVELAGVLHDFCKYDDLGKMYQIVRQYELGNDLLSYGSEILHGPVCAAIMEHEYGINDEEVLMAIKYHTTGRQQMTKTEKLIFIADYIEPGRTIPGVDDIRDMAYNQGSLDKTIYEISKRTVLFLIQKDITVYNKTIDCLNYYNYSDERIKDD
>NZ_CP017090.1|WP_000725167.1|1712138_1712708_-|nicotinate-(nicotinamide)-nucleotide-adenylyltransferase
MKKIVLYGGQFNPIHTAHMIVASEVFHELQPDEFYFLPSFMSPLKKHNNFIDVQHRLTMIQMIIDELGFGDICDDEIKRGGQSYTYDTIKAFKEQHKDSELYFVIGTDQYNQLEKWYQIEYLKEMVTFVVVNRDKNSQNVENAMIAIQIPRVDISSTMIRQRVSEGKSIQVLVPKSVENYIKGEGLYEH

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Crispr_ID: NZ_CP017090_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_7

1737684-1737831

Orphan

Consensus_repeat	Method
CTATGTTGGGGCCCCGTCCCCAACTTCCATTGCCTGT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017090_7

>merge|NZ_CP017090|7|1737684-1737831|PILER-CR
GGGGCCCCGTCCCCAACTTCCATTGCCTGTTGAAATTAGGGTTCCAATTTCTCTGTGTTGGGGCCCCGCCAACTTCCATTGCCTGTTGAAATTGGGGTTCCAATTTCTCTATGTTGGGGCCCCGTCCCCAACTTCCATTGCCTGTAGA

>NZ_CP017090|7|1|1737684-1737831|PILER-CR
GGGGCCCCGTCCCCAACTTCCATTGCCTGTTGAAATTAGGG	TTCCAATTTCTCTGTGTTGGGGCCC
CGCCAACTTCCATTGCCTGTTGAAATTGGGGTTCCAATTTC	TCTATGTTGGGGCCCCGTCCCC
AACTTCCATTGCCTGTAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_000939059.1\|1730428_1730857_-\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|223886
NZ_CP017090.1\|WP_000409157.1\|1739117_1740260_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP017090.1\|WP_001790559.1\|1745004_1745133_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000137774.1\|1728256_1729180_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NZ_CP017090.1\|WP_000985878.1\|1740571_1741585_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NZ_CP017090.1\|WP_000426912.1\|1730860_1731121_-\|IreB-family-regulatory-phosphoprotein	unknown	unknown	gnl\|CDD\|180108
NZ_CP017090.1\|WP_000752909.1\|1742007_1742190_-\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_CP017090.1\|WP_000009238.1\|1741821_1741968_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000066097.1\|1737998_1739117_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP017090.1\|WP_000134779.1\|1730105_1730414_-\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|184235
NZ_CP017090.1\|WP_088401716.1\|1731183_1733814_-\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NZ_CP017090.1\|WP_000648617.1\|1726353_1726977_-\|uridine-kinase	unknown	unknown	gnl\|CDD\|235492
NZ_CP017090.1\|WP_000342258.1\|1729182_1729821_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP017090.1\|WP_000102729.1\|1742796_1744071_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP017090.1\|WP_000044799.1\|1745465_1747232_-\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP017090.1\|WP_088401717.1\|1734156_1736634_-\|ATP-dependent-RecD-like-DNA-helicase	unknown	unknown	gnl\|CDD\|273632
NZ_CP017090.1\|WP_000704122.1\|1742289_1742712_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP017090.1\|WP_000682646.1\|1744231_1745005_-\|tRNA-threonylcarbamoyladenosine-dehydratase	unknown	unknown	gnl\|CDD\|224100
NZ_CP017090.1\|WP_000567017.1\|1736635_1737304_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP017090.1\|WP_000848304.1\|1726976_1728245_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_000939059.1\|1730428_1730857_-\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|223886	COG0816, COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair].	3.40149e-56
NZ_CP017090.1\|WP_000409157.1\|1739117_1740260_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	0
NZ_CP017090.1\|WP_000137774.1\|1728256_1729180_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	7.60817e-104
NZ_CP017090.1\|WP_000985878.1\|1740571_1741585_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	1.35642e-173
NZ_CP017090.1\|WP_000426912.1\|1730860_1731121_-\|IreB-family-regulatory-phosphoprotein	gnl\|CDD\|180108	PRK05473, IreB-like, IreB family regulatory phosphoprotein. IreB (EF1202) was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model pfam06135.	3.05024e-47
NZ_CP017090.1\|WP_000752909.1\|1742007_1742190_-\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	4.22501e-07
NZ_CP017090.1\|WP_000066097.1\|1737998_1739117_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP017090.1\|WP_000134779.1\|1730105_1730414_-\|DUF1292-domain-containing-protein	gnl\|CDD\|184235	PRK13678, PRK13678, hypothetical protein; Provisional.	1.28539e-26
NZ_CP017090.1\|WP_088401716.1\|1731183_1733814_-\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NZ_CP017090.1\|WP_000648617.1\|1726353_1726977_-\|uridine-kinase	gnl\|CDD\|235492	PRK05480, PRK05480, uridine/cytidine kinase; Provisional.	5.13835e-138
NZ_CP017090.1\|WP_000342258.1\|1729182_1729821_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	5.53366e-74
NZ_CP017090.1\|WP_000102729.1\|1742796_1744071_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP017090.1\|WP_000044799.1\|1745465_1747232_-\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP017090.1\|WP_088401717.1\|1734156_1736634_-\|ATP-dependent-RecD-like-DNA-helicase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP017090.1\|WP_000704122.1\|1742289_1742712_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	5.58388e-46
NZ_CP017090.1\|WP_000682646.1\|1744231_1745005_-\|tRNA-threonylcarbamoyladenosine-dehydratase	gnl\|CDD\|224100	COG1179, COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism].	1.59061e-126
NZ_CP017090.1\|WP_000567017.1\|1736635_1737304_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.6095e-16
NZ_CP017090.1\|WP_000848304.1\|1726976_1728245_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	5.98972e-149

>NZ_CP017090.1|WP_000567017.1|1736635_1737304_-|tetratricopeptide-repeat-protein
MIDQQTIYQYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDAEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNEDIDEAITHFKEAVTIDPKHLLSQHALKTFTKMKEEE
>NZ_CP017090.1|WP_088401717.1|1734156_1736634_-|ATP-dependent-RecD-like-DNA-helicase
MSYPTLFDYSMIKGTVEAILFQNSDNFYTVLKVDTIETNEDFDTMPTVVGFLPNIVEGDVYTFKGQVVDHPRYGKQLKAETFEKEMPQTKEAIISYLSSDLFKGVGKKTAQNIVNTLGDNAINDILDDHSVLEKVSGLSKKKQKQIAEQISANQESEKIMIRLHDLGFGPKLSMAIYQFYLGDTLTILDRNPYQLIYDIKGIGFNKADQLARNIGIAYNDNERLKAALLYTLEEECIKQGHTYLPINVVIDLTVDVLNYQDEEVIEPEKLDEMLQYLNEEKRLIIDNEQVAIPSLYYSEIKSVQNLFRIKTHTNKLTEIEQSDLQMHIGEIEDANQVNYAASQKEALQTAINSKVMLLTGGPGTGKTTVIKGIVELYAEIHGLSLDYDDYVNDDYPVVLAAPTGRASKRLQESTGLEAMTIHRLIGWNQDTKPEDILENEINARLIIIDEMSMVDTWLFHQFLSAVPLDAQLIFVGDEDQLPSVGPGQVFKDLIESKAIPRVNLTEVYRQQDGSSIIELAHRMKLGQKIDITQRFHDRSFINCQANQIPTVVEKVVTSAVNKGYTMADIQVLAPMYKGNAGIKRLNQVLQDILNPKKKDTREIEFGDVVFRKGDKVLQLVNRPNDNIFNGDIGVIVGIFWAKENALNKDVLVVDFEGNEITFTKQDMMELTHAYCTSIHKSQGSEFPIVIMPIVKQYFRMLQRPILYTGLTRAKTSLVLLGDPEAFDIGLKTNGQARLTQLCTLLKNYFNSEDEEMLENTATNDTGASQTTIDDQVEAPMSSNDSGEVTSDSTKTDINVLTEATMFKIDPMINMGEITPYDFIER
>NZ_CP017090.1|WP_088401716.1|1731183_1733814_-|alanine--tRNA-ligase
MKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPKKPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMGMEPDKLYVTIHPEDMEAYNIWHKDIGFEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEAYGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQNVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEGRGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEERFHETLEDGLAILNELIKKAKATTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMTTFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEEVSQVEAGETVYFMLTETPFYAVSGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQFGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDFSHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNMAPFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMKSQMKVKSDDQVVEKLTQLQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTEVDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAPIVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL
>NZ_CP017090.1|WP_000426912.1|1730860_1731121_-|IreB-family-regulatory-phosphoprotein
MENFDKTMKFDYEELPTQDVRDVLNNVYRTLDERGYNAVNQIVGYLLSGDPAYIPRQNEARNQIRHIDRDVIMEELVSYYLKEQNK
>NZ_CP017090.1|WP_000939059.1|1730428_1730857_-|Holliday-junction-resolvase-RuvX
MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
>NZ_CP017090.1|WP_000134779.1|1730105_1730414_-|DUF1292-domain-containing-protein
MTEHNHDSQLEINNEEELLTLFDEEGNEVLYRKVLEFYHPEFKKEYVILAEEGAQSDEDDMIELVPMINEPDESGDGGKLVPIETDEEWDMIEEVVNTEMEE
>NZ_CP017090.1|WP_000342258.1|1729182_1729821_-|O-methyltransferase
MDDLNKKYLIDLHQHQNSSIEVLREFAEGNEVPIVDRLTLDLIKQLIRMNNVKNILEIGTAIGYSSMQFASISDDIHVTTIERNETMIQYAKQNLATYHFENQVRIIEGNALEQFENVNDKVYDMIFIDAAKAQSKKFFEIYTPLLKHQGLVITDNVLYHGFVSDIGIVRSRNVRQMVKKVQDYNEWLIKQPGYTTNFLNIDDGLAISIKGE
>NZ_CP017090.1|WP_000137774.1|1728256_1729180_-|U32-family-peptidase
MTELLVTPKSLSHMETLIDLGADAFVIGEQKFGLRLPGEFNRQQMTEAVALAHKNDKKVYAAVNGLFHNYHLDAVEDYINFLHEIRVDRIIFGDPAVVMYVKAQENPIPLHWNAETLVTNHFQCNYWGKRGASRAVLARELNLDEIINIKENSNVEIEVQVQGMTCMFQSKRMLLGNYYTFQDRQMKIERRNDEQSLLLYDEERQNNYPVYEDYNGTHIMSPNDICLIEELAPFFEAGIDSFKIDGILQTEEYINVVTEQYRQAIDLYNEDPEIYEDEKFMLIDPIEEIQPDHRPFDEGFLYKQTVY
>NZ_CP017090.1|WP_000848304.1|1726976_1728245_-|U32-family-peptidase
MKTIEEIKSTPKTVMKKPELLAPAGNLEKLKIAVHYGADAVFLGGQEYGLRSNADNFTMEEIAEGVEFANRYGAKIYVTTNIIAHDENIEGLESYLRNLEKTGATGIIVADPLIIETCKEVAPKLEIHLSTQQSLSNYKAVEYWKEEGLDRVVLARETGAMEMREMKEKVDIEIEAFIHGAMCIAYSGRCTLSNHMTARDSNRGGCCQSCRWDYELLEVDDNGELDVFYNQGEVTPFAMSPKDLKLIESIPQMMDIGVDSLKIEGRMKSIHYIATVVSVYRKVIDAYAADPDNFKINPEWLIELDKCANRDTAPAFFEGTPGYEEQMFGQQQSKKSPFDFCGLVLDYNEDTKIATIQQRNNFKPGQEIEFFGPEIETFTQVVEAIYDEEGNSLDAARHPLQIVQIKVDRPIYPNNMMRKEIG
>NZ_CP017090.1|WP_000648617.1|1726353_1726977_-|uridine-kinase
MKATTIIGIAGGSGSGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTKKYADIIIPEGGSNKVAIDIMTTKIQSLVSKQ
>NZ_CP017090.1|WP_000066097.1|1737998_1739117_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV
>NZ_CP017090.1|WP_000409157.1|1739117_1740260_-|cysteine-desulfurase
MEIYADYAATTPVKPEVVDAMMMIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGADTHEIIFTSGATESNNTAIKGIVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLDVDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYDIQDIIAETNAYFHVDAVQAIGHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLAQIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFPFVEVEMMLTLLDMAQIYVSSGSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTENEINAIVAEIHKIYFKFKEES
>NZ_CP017090.1|WP_000985878.1|1740571_1741585_+|LLM-class-flavin-dependent-oxidoreductase
MAIKYSALNLVPIREGDDERTAINDMVKLAQHLDELSYERYWIAEHHNAPNLVSSATALLIQHTLEHTKHIRVGSGGIMLPNHAPLIVAEQFGTMATLFPNRVDLGLGRAPGTDMMTASALRRDQHDGVYKFPEEVSLLQQYFGPAHQQAYVRAYPAVGKNVPLYILGSSTDSAHLAARKGLPYVFAGHFAPQQMKEAIEIYKTLFEPSDVLDEPYVIVCLNTIVAENDDEAQYLASSMAQVMVSITRGRMQPVQPPTHDLQNILTPREYAMAMERQKISLIGSENTVQQKIQDFMETYGEVNEIMAISYIYDKDMQLDSYRRFKNVINQINEKNTL
>NZ_CP017090.1|WP_000009238.1|1741821_1741968_-|hypothetical-protein
MSFMDKAKDAVEKFKNSDNEQVKNVKDKINEYTGSNNEEKKENEDKEK
>NZ_CP017090.1|WP_000752909.1|1742007_1742190_-|CsbD-family-protein
MADESKFDQFKGNVKETVGNVTDNKELEKEGQQDKATGKAKEVVENAKNKITDAIDKLKK
>NZ_CP017090.1|WP_000704122.1|1742289_1742712_-|Rrf2-family-transcriptional-regulator
MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRGAKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTLKYLAEYVDTSEDLDGYMFYI
>NZ_CP017090.1|WP_000102729.1|1742796_1744071_+|replication-associated-recombination-protein-A
MSTEPLASRMRPKNIDEIISQQHLVGPKGIIRRMVDTKKLTSMIFYGPPGIGKTSIAKAISGSTQYKFRQLNAVTNTKKDMQLVVEEAKMSGQVILLLDEIHRLDKAKQDFLLPHLENGKIVLIGATTSNPYHAINPAIRSRAQIFELYPLNDEDVRQALTRAIEDDENGLKTYQPKIDEDAMTYFSTQSQGDVRSALNALELAVLSADNDKDGYRHVTLQDAKDCLQKGAFVSDKDGDMHYDVMSAFQKSIRGSDVNAALHYLARLIEAGDLPTIVRRLLVISYEDIGLASPNAGQRTLAAIESAERLGLPEARIPLSQAVIELCLSPKSNSAMSAIDSALSDIRNGHVGQIPNHLKDGHYQGAKDLGRSIGYKYPHQYVNGYVSQQYLPDKLKNKIYYEPKTTSKSEQQLKEIYNNLLKQRP
>NZ_CP017090.1|WP_000682646.1|1744231_1745005_-|tRNA-threonylcarbamoyladenosine-dehydratase
MKHQFSRNELAIGQQGLDLLKQQTVVILGVGGVGSFAAEALARTNIGHIILIDKDDVDITNVNRQLHALTTTVGQSKVSLMEERIKLINPDCKVTPLHMFYTEETYEEIFDNYDIDYFVDASDTIMYKVHLMKECLDRGIKVISSMGAANKTDPTRFTISDISKTHTDPMAKIIRQKLKKLGIRKGIPVVFSDESPIVIREDVKDIVGDKNAINRKGQMPPSSNAFVPSVVGLICASYVVNDVLKDIPVRRIKDKGQ
>NZ_CP017090.1|WP_001790559.1|1745004_1745133_-|hypothetical-protein
MGFIAFNKCFLVEFWENNQSDNAKYKILSYYVLMYKSVKEVK
>NZ_CP017090.1|WP_000044799.1|1745465_1747232_-|aspartate--tRNA-ligase
MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEALKIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENVNVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGARDYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDIEMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELIDVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVKVVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELGLIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIVLNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDRLVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH

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Crispr_ID: NZ_CP017090_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_8

2101302-2101383

Orphan

Consensus_repeat	Method
GGCCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_8

>merge|NZ_CP017090|8|2101302-2101383|CRISPRCasFinder
GGCCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCCACCCCAACTTGCATTGT

>NZ_CP017090|8|7|2101302-2101383|CRISPRCasFinder
GGCCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_001557458.1\|2094279_2095710_-\|MAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|367591
NZ_CP017090.1\|WP_000120297.1\|2106290_2107550_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236768
NZ_CP017090.1\|WP_001549197.1\|2110118_2110253_-\|delta-lysin-family-phenol-soluble-modulin	unknown	unknown	gnl\|CDD\|173213
NZ_CP017090.1\|WP_000206625.1\|2099857_2101081_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|181490
NZ_CP017090.1\|WP_001094921.1\|2111054_2111198_+\|cyclic-lactone-autoinducer-peptide	unknown	unknown	gnl\|CDD\|129030
NZ_CP017090.1\|WP_000671712.1\|2093974_2094265_-\|MAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|367591
NZ_CP017090.1\|WP_000791411.1\|2098366_2099422_-\|bi-component-leukocidin-LukGH-subunit-H	unknown	unknown	gnl\|CDD\|369625
NZ_CP017090.1\|WP_001105696.1\|2110488_2111052_+\|accessory-gene-regulator-ArgB-like-protein	unknown	unknown	gnl\|CDD\|226899
NZ_CP017090.1\|WP_000917289.1\|2105063_2105348_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP017090.1\|WP_000681968.1\|2091692_2091869_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000691584.1\|2091054_2091435_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_CP017090.1\|WP_000522381.1\|2107746_2108373_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NZ_CP017090.1\|WP_000867951.1\|2108733_2109519_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
NZ_CP017090.1\|WP_000240642.1\|2103371_2104988_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP017090.1\|WP_001068542.1\|2092409_2093696_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|181512
NZ_CP017090.1\|WP_001045079.1\|2101524_2102832_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP017090.1\|WP_000239607.1\|2096098_2097091_+\|sphingomyelin-phosphodiesterase	unknown	unknown	gnl\|CDD\|132436
NZ_CP017090.1\|WP_000595392.1\|2097328_2098345_-\|bi-component-leukocidin-LukGH-subunit-G	unknown	unknown	gnl\|CDD\|369625
NZ_CP017090.1\|WP_000197635.1\|2105522_2106266_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP017090.1\|WP_000990056.1\|2092111_2092210_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_001557458.1\|2094279_2095710_-\|MAP-domain-containing-protein	gnl\|CDD\|367591	pfam03642, MAP, MAP domain. This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein). The protein has been found in a wide range of extracellular matrix proteins.	1.06e-32
NZ_CP017090.1\|WP_000120297.1\|2106290_2107550_-\|hypothetical-protein	gnl\|CDD\|236768	PRK10819, PRK10819, transport protein TonB; Provisional.	6.51148e-10
NZ_CP017090.1\|WP_000206625.1\|2099857_2101081_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_CP017090.1\|WP_001094921.1\|2111054_2111198_+\|cyclic-lactone-autoinducer-peptide	gnl\|CDD\|129030	smart00794, AgrD, Staphylococcal AgrD protein. This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.	3.13559e-15
NZ_CP017090.1\|WP_000240642.1\|2103371_2104988_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP017090.1\|WP_000791411.1\|2098366_2099422_-\|bi-component-leukocidin-LukGH-subunit-H	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.84035e-77
NZ_CP017090.1\|WP_001105696.1\|2110488_2111052_+\|accessory-gene-regulator-ArgB-like-protein	gnl\|CDD\|226899	COG4512, AgrB, Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription].	6.65966e-71
NZ_CP017090.1\|WP_000917289.1\|2105063_2105348_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	5.94304e-45
NZ_CP017090.1\|WP_000522381.1\|2107746_2108373_+\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	8.42197e-117
NZ_CP017090.1\|WP_000691584.1\|2091054_2091435_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	7.00479e-47
NZ_CP017090.1\|WP_001549197.1\|2110118_2110253_-\|delta-lysin-family-phenol-soluble-modulin	gnl\|CDD\|173213	PRK14752, PRK14752, delta-lysin family phenol-soluble modulin.	8.25732e-15
NZ_CP017090.1\|WP_000867951.1\|2108733_2109519_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	5.69545e-126
NZ_CP017090.1\|WP_000671712.1\|2093974_2094265_-\|MAP-domain-containing-protein	gnl\|CDD\|367591	pfam03642, MAP, MAP domain. This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein). The protein has been found in a wide range of extracellular matrix proteins.	1.15662e-32
NZ_CP017090.1\|WP_001068542.1\|2092409_2093696_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|181512	PRK08637, PRK08637, hypothetical protein; Provisional.	0
NZ_CP017090.1\|WP_001045079.1\|2101524_2102832_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	7.96864e-82
NZ_CP017090.1\|WP_000239607.1\|2096098_2097091_+\|sphingomyelin-phosphodiesterase	gnl\|CDD\|132436	TIGR03395, Sphingomyelinase_C, sphingomyelin phosphodiesterase. Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis].	2.38027e-136
NZ_CP017090.1\|WP_000595392.1\|2097328_2098345_-\|bi-component-leukocidin-LukGH-subunit-G	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.05827e-99
NZ_CP017090.1\|WP_000197635.1\|2105522_2106266_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.67124e-11

>NZ_CP017090.1|WP_000206625.1|2099857_2101081_+|ArgE/DapE-family-deacylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKAGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINDVDSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVEQDEIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>NZ_CP017090.1|WP_000791411.1|2098366_2099422_-|bi-component-leukocidin-LukGH-subunit-H
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNRKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>NZ_CP017090.1|WP_000595392.1|2097328_2098345_-|bi-component-leukocidin-LukGH-subunit-G
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTEPNYDKETVFIKAKGTIGSGLRILDPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>NZ_CP017090.1|WP_000239607.1|2096098_2097091_+|sphingomyelin-phosphodiesterase
MVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKDETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
>NZ_CP017090.1|WP_001557458.1|2094279_2095710_-|MAP-domain-containing-protein
MKFKSLITTTLALGVIASTGANFNTNEASAAAKPLDKSSSTLHHGHSNIQIPYTITVNGTSQNILSSLTFNKNQNISYKDIENKVKSVLYFNRGISDIDLRLSKQAEYTVHFKNGTKRVIDLKSGIYTADLINTSDIKAISVNVDTKKQPKDKAKANVQVPYTITVNGTSQNILSNLTFNKNQNISYKDLEGKVKSVLESNRGITDVDLRLSKQAKYTVNFKNGTKKVIDLKSGIYTANLINSSDIKSININVDTKKHIENKAKRNYQVPYSINLNGTSTNILSNLSFSNKPWTNYKNLTSQIKSVLKHDRGISEQDLKYAKKAYYTVYFKNGGKRILQLNSKNYTANLVHAKDVKRIEITVKTGTKAKADRYVPYTIAVNGTSTPILSKLKISNKQLISYKYLNDKVKSVLKSERGISDLDLKFAKQAKYTVYFKNGKKQVVNLKSDIFTPNLFSAKDIKKIDIDVKQYTKSKKK
>NZ_CP017090.1|WP_000671712.1|2093974_2094265_-|MAP-domain-containing-protein
MKFPVTINKFENIVSNEFVFYNASKITINDLSIKLKSAMANDQGITKHDIGLAERAVYKVYFKNGSSKYVDLKTEYKDERVFKATDIKKVDIELKF
>NZ_CP017090.1|WP_001068542.1|2092409_2093696_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MNPLAQSLNEQLQQSNATAFTMLSDLGQNMFYPKGILSQSAEAKSTTYNATIGMATNKDGKMFASSLDAMFNDLTPDEIFPYAPPQGIEELRDLWQQKMLRDNPELSIDNMSLPIVTNALTHGLSLVGDLFVNQGDTILLPEHNWGNYKLVFNTRNGANLQTYPIFDKDGHYTTDSLVEALQSYNKDKVIMILNYPNNPTGYTPTHKEVTTIVDAIKALADKGTKVIAVVDDAYYGLFYEDVYTQSLFTALSNLNSNAILPVRLDGATKEFFAWGFRVGFMTFGTSDQTTKEVLEAKVKGLIRSNISSGPLPTQSAVKHVLKNNKQFDKEIEQNIQTLKERYEVTKEVVYADQYHSHWQAYDFNSGYFMAIKVHDVDPEELRKHLIEKYSIGVIALNATDIRIAFSCVEKEDIPHVFDSIAKAIDDLR
>NZ_CP017090.1|WP_000990056.1|2092111_2092210_-|hypothetical-protein
MMWWQEGMMTLITGGLLIIFRLWLELKWKNKK
>NZ_CP017090.1|WP_000681968.1|2091692_2091869_-|hypothetical-protein
MKHLTKIFVVLAIILFIIGYYLQATNHESQGIKLLLAAIMFMICAFISRSNDRRKNSK
>NZ_CP017090.1|WP_000691584.1|2091054_2091435_-|GntR-family-transcriptional-regulator
MKIILKNNSDFPIYEQIKQQVKQNILKGHVAPGEHLPSMRELAKDLQVSLITTKRAYEDLEKDGFVTTIRGKGTFVKEQDSSILKEKQFFTIENLVKELVNEAQAIEMSLEELQDILTFIYEEESS
>NZ_CP017090.1|WP_001045079.1|2101524_2102832_+|TrkH-family-potassium-uptake-protein
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQHMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSAAGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>NZ_CP017090.1|WP_000240642.1|2103371_2104988_-|chaperonin-GroEL
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>NZ_CP017090.1|WP_000917289.1|2105063_2105348_-|co-chaperone-GroES
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>NZ_CP017090.1|WP_000197635.1|2105522_2106266_+|CPBP-family-intramembrane-metalloprotease
MTRLWASLLTVIIYILSQFLPLLIVKKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVLTQIYGGQQVSPNTEKLIIIARKIPIFIFFVSIIGPLLEEYVFRKVIFGELFNAIKGNRIVAFIIATTVSSLIFALAHNDFKFIPVYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP
>NZ_CP017090.1|WP_000120297.1|2106290_2107550_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNITSPSVNSEMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPNPKPDPDNPKPKPDPKPDPDKPKPNLDPKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPDQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>NZ_CP017090.1|WP_000522381.1|2107746_2108373_+|nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEMTSKEFNIPKSWKLIAQMPFGDIREAAGEKTFNPVEDRFVIKK
>NZ_CP017090.1|WP_000867951.1|2108733_2109519_+|carbon-nitrogen-family-hydrolase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNAEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNYQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>NZ_CP017090.1|WP_001549197.1|2110118_2110253_-|delta-lysin-family-phenol-soluble-modulin
MSCLILRIFILIKEGVISMAQDIISTIGDLVKWIIDTVNKFTKK
>NZ_CP017090.1|WP_001105696.1|2110488_2111052_+|accessory-gene-regulator-ArgB-like-protein
MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQIIVGNFFKILVTYSISIFLSVFLFTLVTHLSYMLIRYNAHGAHAKSSILCYIQSILTFVFVPYFLINIDINFTYLLALSIIGLISVVIYAPAATKKQPIPIKLVKRKKYLSIIMYLLVLILSLIIHPFYAQFMLLGILVESITLLPIFFPKED
>NZ_CP017090.1|WP_001094921.1|2111054_2111198_+|cyclic-lactone-autoinducer-peptide
MNTLVNMFFDFIIKLAKAIGIVGGVNACSSLFDEPKVPAELTNLYDK

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Crispr_ID: NZ_CP017090_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_9

2245469-2245549

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3,TnsE_C

The CRISPR arrays of NZ_CP017090_9

>merge|NZ_CP017090|9|2245469-2245549|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTCAACTTTAGTTGTTAGGGGCTTCT

>NZ_CP017090|9|8|2245469-2245549|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCATGCGCTTAGCGCAGGCGCTCCTACTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_088401733.1\|2251066_2251786_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378937
NZ_CP017090.1\|WP_000070866.1\|2235265_2235709_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP017090.1\|WP_088401732.1\|2248409_2249189_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP017090.1\|WP_000019734.1\|2243117_2244095_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP017090.1\|WP_011867746.1\|2254852_2256385_-\|hypothetical-protein	TnsE_C	TnsE	gnl\|CDD\|376049
NZ_CP017090.1\|WP_088401734.1\|2251778_2252699_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP017090.1\|WP_001792784.1\|2246668_2246827_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000808817.1\|2240343_2240574_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_001557163.1\|2236761_2238081_+\|ISL3-like-element-IS1181-family-transposase	unknown	unknown	gnl\|CDD\|225995
NZ_CP017090.1\|WP_001024095.1\|2241978_2242644_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP017090.1\|WP_000123398.1\|2238298_2239672_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NZ_CP017090.1\|WP_011867745.1\|2253804_2254515_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP017090.1\|WP_011867740.1\|2249694_2250507_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|237134
NZ_CP017090.1\|WP_001127960.1\|2240604_2241543_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP017090.1\|WP_011867744.1\|2252786_2253812_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP017090.1\|WP_001123303.1\|2235908_2236322_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP017090.1\|WP_000003759.1\|2242795_2243116_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP017090.1\|WP_001802298.1\|2245884_2245989_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000495669.1\|2244360_2245452_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000370925.1\|2247484_2248342_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_088401733.1\|2251066_2251786_-\|ABC-transporter-permease	gnl\|CDD\|378937	pfam12730, ABC2_membrane_4, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.01241e-31
NZ_CP017090.1\|WP_000070866.1\|2235265_2235709_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NZ_CP017090.1\|WP_088401732.1\|2248409_2249189_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.08662e-104
NZ_CP017090.1\|WP_000019734.1\|2243117_2244095_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.49165e-107
NZ_CP017090.1\|WP_088401734.1\|2251778_2252699_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	7.27822e-104
NZ_CP017090.1\|WP_011867746.1\|2254852_2256385_-\|hypothetical-protein	gnl\|CDD\|376049	pfam18623, TnsE_C, TnsE C-terminal domain. The bacterial transposon Tn7 facilitates horizontal transfer by directing transposition into actively replicating DNA with the element-encoded protein TnsE. Structural analysis of the C-terminal domain of TnsE identified a central V-shaped loop that toggles between two distinct conformations. It is suggested that a conformational change within the C-terminal domain of TnsE underlies target site selection by regulating stable engagement of the target DNA while providing a signal for activating transposition.	3.99221e-12
NZ_CP017090.1\|WP_001557163.1\|2236761_2238081_+\|ISL3-like-element-IS1181-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.75686e-114
NZ_CP017090.1\|WP_001024095.1\|2241978_2242644_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.27122e-47
NZ_CP017090.1\|WP_000123398.1\|2238298_2239672_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	4.11455e-06
NZ_CP017090.1\|WP_011867745.1\|2253804_2254515_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.18376e-91
NZ_CP017090.1\|WP_011867740.1\|2249694_2250507_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|237134	PRK12554, PRK12554, undecaprenyl pyrophosphate phosphatase; Reviewed.	1.99773e-118
NZ_CP017090.1\|WP_001127960.1\|2240604_2241543_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NZ_CP017090.1\|WP_011867744.1\|2252786_2253812_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.41772e-46
NZ_CP017090.1\|WP_001123303.1\|2235908_2236322_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	3.14887e-46
NZ_CP017090.1\|WP_000003759.1\|2242795_2243116_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NZ_CP017090.1\|WP_000370925.1\|2247484_2248342_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.8047e-59

>NZ_CP017090.1|WP_000495669.1|2244360_2245452_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDKKVVTEPKNTKVENGKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP017090.1|WP_000019734.1|2243117_2244095_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NZ_CP017090.1|WP_000003759.1|2242795_2243116_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NZ_CP017090.1|WP_001024095.1|2241978_2242644_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGEQDIKDALTQFEIEKD
>NZ_CP017090.1|WP_001127960.1|2240604_2241543_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NZ_CP017090.1|WP_000808817.1|2240343_2240574_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NZ_CP017090.1|WP_000123398.1|2238298_2239672_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVKKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NZ_CP017090.1|WP_001557163.1|2236761_2238081_+|ISL3-like-element-IS1181-family-transposase
MCNDTLELLRIKDENIKYINQEIDVIIKGKKATVVNAVLTYKPSACYCCGVKNEGQIHKHGKRVSRITLLKTQGYNTYLNLAKQRFKCLECNGTFTAKTSIVDESCFISRCVTQKVIEEATKVKTEIDTAEDNCISPSTVSRIRTKAANSLRIKPFNCLPEHIAMDEFKSVKNVTGSMSFIFIDNDTHDVIDILENRTTRFLRAYFERFDLKNRQQVKTVTIDMYEPYVRLFRDLFPNAAIIFDRFHIVQHLNRELNKYRVQVMNEYRNKKGPNYTIFKNNWKVLLMDTSKTIFSKYRWNKSFKAYKRSSDIVEFMLSKDDILRRSYELVQGLRKDLRLCNWPKFINRLNSVSKKSVSKGVWKVVKYYRKHQRMLRNTIYYPAFNNGAIEGINNKIKLIKRISFGYRNFNNFKARIMMIFSLYKGEKKKTTKPNNGLAA
>NZ_CP017090.1|WP_001123303.1|2235908_2236322_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP017090.1|WP_000070866.1|2235265_2235709_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP017090.1|WP_001802298.1|2245884_2245989_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NZ_CP017090.1|WP_001792784.1|2246668_2246827_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NZ_CP017090.1|WP_000370925.1|2247484_2248342_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP017090.1|WP_088401732.1|2248409_2249189_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKNISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATTGGVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDEVRNEAHHLLKLVGISAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLNILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP017090.1|WP_011867740.1|2249694_2250507_-|undecaprenyl-diphosphate-phosphatase
MTELCTLIQYLLLGLVQGITEPIPISSSGHIIIVRELFGIEARGLSFEIFVNFASLLAVLLIYRHDIYRLIKNGILFITKKDEQAKSDFQFILYLVIGTIPVGVVGLLFGDVIGEALSNTKIVGFTLLITAVAIWMIRNLRGRKKDGDLTSKDAVIVGLAQAVAVTPGISRSGASIVASMLVGMKQETALRFSFLLYIPVSLGTTMLEVPEIVQDPNFDALMIPYLIAFIAAFIATYFALKALINIMAKGNLAYFSYYCVVVGVLVILFL
>NZ_CP017090.1|WP_088401733.1|2251066_2251786_-|ABC-transporter-permease
MVNLFLTEVLKLKRSSMFLISILGAAVAPFVVVIATYLNEPSILFKELFYNVNLYTVLIIGVPLYGVVTTYLFNREYMENTLKNILAIPVSRIGFIVSKMLLLFIWIMMLTLIAWTLTLVLGMLTQFDGLSISLVMESLSQFSIGGMFLFILSTPIILVTLVMKNYVPTIIFTVVITLINVMGGNSEHRALFPWAAAGDIANNTLPLTYPPEYSYIAITATALAGFIAMIVYFNKTDIH
>NZ_CP017090.1|WP_088401734.1|2251778_2252699_-|ABC-transporter-ATP-binding-protein
MNTVIKTTNLSKIYGEQKSVDQLSITVNQGEIYGFLGRNGAGKTTTIRMLLGLIRPTYGQIEIFGENLFKNQKRILRRIGSIVEVPGFYENLTAKENLLINAKIIGVHKKNAIDEALEIVGLQNENKKLVGKYSLGMKQRLGIARALLHSPELLILDEPTNGLDPIGIKEMRRLIKSLAAERNITILISSHILSEIEQLADHMGIIHEGKLLEEIGIDHLRKRNRKYLEFQVSNDNKATMLLEEHFNIFDYEVYDEGMVRVYSHLGEQGTINRMFVQNDINVLKIKMSEDRLEDYFERLVGGGTIG
>NZ_CP017090.1|WP_011867744.1|2252786_2253812_-|HAMP-domain-containing-histidine-kinase
MNDKIIFLIMLQFITITGIFMIDIYYQTPAIVRWFLFIVLFFITAILLFKRIHYHTQLKRMNVELERAINGNLNTRLLANHDKFFNELTFSINDLIEQLEKVQIQSIKSQTARKRILSSISHDIRTPLTSIIGYIDALQDDISTSEEEKRKYLEIVSRKSNGLKQLLDELFNMAKIEANEFLLKEELLDFAEVTRESIIEFLPELKKEEIELIVRIPEEDCLIMADHQSLIRIIGNLIKNAVHYGKDGKVLGIELTETTNDFQLLIWDQGSGISNVDIGNVFERMYRSDYSRNNSFGGSGLGLSIAKELVEKNHGRIWVESIPWKKTTFGFSIPKHSNKGI
>NZ_CP017090.1|WP_011867745.1|2253804_2254515_-|response-regulator-transcription-factor
MEDIRILIADDEKEIRNLLKKYLERELYKVDVAVNGEEALRLFDKNQYNLLILDLMMPKVDGIEVCRRLRNKTNIPILMLTAKDQEVDKVLGLGIGADDYITKPFSINEVIARVKSLMRRFLILGSDGESLEKTSIKYKDLTIDLKKYIIVIGGEEVPLTAKEFELLKFLAAHNEQVFTKTQLFRNVWESDYIEDDNTVMVHIRKLRKKIEVDPSNPQFIQTVWGIGYKFVGEQDE
>NZ_CP017090.1|WP_011867746.1|2254852_2256385_-|hypothetical-protein
MSSQQVKIKWPFKKGEKARLIWIGDPFRNNNKMMLHAYFRARGVTEKILMDWGTLPCLAIQHYYSDGVITTSQPPQGVQEVDITIYPNRVQYYEKLWNVHGSNDPATSRSFIFSFEGKNVILPVIEVLRSILAPNGFLLYRLFESNSFPQFFTETYEPNKIHLSFSSLYELKYTRTAFIYQLVWLLTNRDLRHVYESIAFTWLQEQTLKFEWTFTQPITVTARIKEDQNTWTVLQIVNVKNKYIPYENISISHPEIRDNEKSKEAKKYTYRSLNKKDGEGGFTLDEQVDGATEDFDFVQMNQLGHEYTSVPKVKQVKLGSTKQRLEEDENTKRYYGDDHYIRSTADSGGQQLARGLEHQMLHEIKAQGEIQDFINVLKVLEQYPEVKAIRAFTDVLPESVGHRKYTKLSDGITKRSYIIAEVYMMNGNHFNIIEVERERRSLSTLILSSSSKQNWSAICNYILLNLVNASGNWTRKSLNSINTKGIKIEKTKHSSKGVQHRAGILLGKLL

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Crispr_ID: NZ_CP017090_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_10

2271422-2271507

Orphan

Consensus_repeat	Method
CCAACTGATTTTTGCGTATCATTAGT	CRISPRCasFinder

1 spacers

TnsE_C

The CRISPR arrays of NZ_CP017090_10

>merge|NZ_CP017090|10|2271422-2271507|CRISPRCasFinder
CCAACTGATTTTTGCGTATCATTAGTTTGCATATCTTTAGCTTTATTGTTTGCAACTGGGCCAACTGATTTTTGCGTATCATTAGT

>NZ_CP017090|10|9|2271422-2271507|CRISPRCasFinder
CCAACTGATTTTTGCGTATCATTAGT	TTGCATATCTTTAGCTTTATTGTTTGCAACTGGG
CCAACTGATTTTTGCGTATCATTAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_011867750.1\|2262064_2262904_-\|heteromeric-transposase-endonuclease-subunit-TnsA	unknown	unknown	gnl\|CDD\|378037
NZ_CP017090.1\|WP_011867746.1\|2254852_2256385_-\|hypothetical-protein	TnsE_C	TnsE	gnl\|CDD\|376049
NZ_CP017090.1\|WP_001141007.1\|2290513_2291956_-\|multidrug-efflux-MFS-transporter-LmrS	unknown	unknown	gnl\|CDD\|129794
NZ_CP017090.1\|WP_095236857.1\|2258245_2259910_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379165
NZ_CP017090.1\|WP_000927371.1\|2267114_2269247_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP017090.1\|WP_001237506.1\|2292850_2294194_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP017090.1\|WP_000636857.1\|2292278_2292752_-\|multidrug-efflux-transporter-SepA	unknown	unknown	gnl\|CDD\|374975
NZ_CP017090.1\|WP_000894032.1\|2280222_2281155_-\|YbbR-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227193
NZ_CP017090.1\|WP_011867749.1\|2259911_2262068_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|378147
NZ_CP017090.1\|WP_000167867.1\|2282154_2283063_-\|arginase	unknown	unknown	gnl\|CDD\|212515
NZ_CP017090.1\|WP_000047255.1\|2294370_2295054_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NZ_CP017090.1\|WP_000648723.1\|2269692_2270799_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP017090.1\|WP_000958531.1\|2289301_2290366_-\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|378455
NZ_CP017090.1\|WP_000334463.1\|2263055_2264861_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP017090.1\|WP_000083807.1\|2265541_2267080_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP017090.1\|WP_001292149.1\|2269258_2269693_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
NZ_CP017090.1\|WP_000347896.1\|2281156_2281966_-\|TIGR00159-family-protein	unknown	unknown	gnl\|CDD\|224539
NZ_CP017090.1\|WP_000884735.1\|2295072_2296260_-\|UDPGP-type-1-family-protein	unknown	unknown	gnl\|CDD\|133036
NZ_CP017090.1\|WP_011867747.1\|2256365_2258234_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379756
NZ_CP017090.1\|WP_000521495.1\|2278840_2280196_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_011867750.1\|2262064_2262904_-\|heteromeric-transposase-endonuclease-subunit-TnsA	gnl\|CDD\|378037	pfam08722, Tn7_Tnp_TnsA_N, TnsA endonuclease N terminal. The Tn7 transposase is composed of proteins TnsA and TnsB. DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	4.06402e-24
NZ_CP017090.1\|WP_011867746.1\|2254852_2256385_-\|hypothetical-protein	gnl\|CDD\|376049	pfam18623, TnsE_C, TnsE C-terminal domain. The bacterial transposon Tn7 facilitates horizontal transfer by directing transposition into actively replicating DNA with the element-encoded protein TnsE. Structural analysis of the C-terminal domain of TnsE identified a central V-shaped loop that toggles between two distinct conformations. It is suggested that a conformational change within the C-terminal domain of TnsE underlies target site selection by regulating stable engagement of the target DNA while providing a signal for activating transposition.	3.99221e-12
NZ_CP017090.1\|WP_001141007.1\|2290513_2291956_-\|multidrug-efflux-MFS-transporter-LmrS	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.85929e-81
NZ_CP017090.1\|WP_095236857.1\|2258245_2259910_-\|ATP-binding-protein	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	1.21275e-17
NZ_CP017090.1\|WP_000927371.1\|2267114_2269247_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.02509e-68
NZ_CP017090.1\|WP_001237506.1\|2292850_2294194_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.92638e-43
NZ_CP017090.1\|WP_000636857.1\|2292278_2292752_-\|multidrug-efflux-transporter-SepA	gnl\|CDD\|374975	pfam17080, SepA, Multidrug Resistance efflux pump. SepA is a drug efflux protein that is involved in bacterial multidrug resistance. It is predicted to have four transmembrane domains.	3.20059e-30
NZ_CP017090.1\|WP_000894032.1\|2280222_2281155_-\|YbbR-like-domain-containing-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	6.26423e-118
NZ_CP017090.1\|WP_011867749.1\|2259911_2262068_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|378147	pfam09299, Mu-transpos_C, Mu transposase, C-terminal. Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.	7.76052e-08
NZ_CP017090.1\|WP_000167867.1\|2282154_2283063_-\|arginase	gnl\|CDD\|212515	cd09989, Arginase, Arginase family. This family includes arginase, also known as arginase-like amidino hydrolase family, and related proteins. Arginase is a binuclear Mn-dependent metalloenzyme and catalyzes hydrolysis of L-arginine to L-ornithine and urea (Arg, EC 3.5.3.1), the reaction being the fifth and final step in the urea cycle, providing the path for the disposal of nitrogenous compounds. Arginase controls cellular levels of arginine and ornithine which are involved in protein biosynthesis, and in production of creatine, polyamines, proline and nitric acid. In vertebrates, at least two isozymes have been identified: type I (ARG1) cytoplasmic or hepatic liver-type arginase and type II (ARG2) mitochondrial or non-hepatic arginase. Point mutations in human arginase ARG1 gene lead to hyperargininemia with consequent mental disorders, retarded development and early death. Hyperargininemia is associated with a several-fold increase in the activity of the mitochondrial arginase (ARG2), causing persistent ureagenesis in patients. ARG2 overexpression plays a critical role in the pathophysiology of cholesterol mediated endothelial dysfunction. Thus, arginase is a therapeutic target to treat asthma, erectile dysfunction, atherosclerosis and cancer.	9.8301e-146
NZ_CP017090.1\|WP_000047255.1\|2294370_2295054_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	2.41003e-66
NZ_CP017090.1\|WP_000648723.1\|2269692_2270799_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP017090.1\|WP_000958531.1\|2289301_2290366_-\|P-loop-NTPase	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	6.43129e-115
NZ_CP017090.1\|WP_000334463.1\|2263055_2264861_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP017090.1\|WP_000083807.1\|2265541_2267080_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP017090.1\|WP_001292149.1\|2269258_2269693_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NZ_CP017090.1\|WP_000347896.1\|2281156_2281966_-\|TIGR00159-family-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	2.13611e-103
NZ_CP017090.1\|WP_000884735.1\|2295072_2296260_-\|UDPGP-type-1-family-protein	gnl\|CDD\|133036	cd04193, UDPGlcNAc_PPase, UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.	2.43588e-149
NZ_CP017090.1\|WP_011867747.1\|2256365_2258234_-\|hypothetical-protein	gnl\|CDD\|379756	pfam15978, TnsD, Tn7-like transposition protein D. TnsD is a family of putative Tn7-like transposition proteins type D.	1.7878e-109
NZ_CP017090.1\|WP_000521495.1\|2278840_2280196_-\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0

>NZ_CP017090.1|WP_000648723.1|2269692_2270799_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NZ_CP017090.1|WP_001292149.1|2269258_2269693_+|mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NZ_CP017090.1|WP_000927371.1|2267114_2269247_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHSQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP017090.1|WP_000083807.1|2265541_2267080_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP017090.1|WP_000334463.1|2263055_2264861_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEDGTPVVALATQENVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP017090.1|WP_011867750.1|2262064_2262904_-|heteromeric-transposase-endonuclease-subunit-TnsA
MAKRKRTSKIDKWIKEGRGTGSGADYQPWLKIQDVSSLGRSTRLKGIKTGRQHEFLSDLERNYFYLTEFSDAVLDIREQFPLLPQEETIVIAEELGIKHPADPKTGDPIVMSTDFLLTVDKGQGVFEVAHTIKMKDKLLEERVLEKFEIERVYWERRGISWGIVTEEEIDKTVARNISYIHDYFDIRNYDVYREMADQQIDDLSLSLMSRLLNNSQSIREIASEFDADTHLPFGSGVTLFYHLLAKKIMVTDMYKPIDLEKPTDVKYVDESKLEKVKYG
>NZ_CP017090.1|WP_011867749.1|2259911_2262068_-|DDE-type-integrase/transposase/recombinase
MIYINQVFQYVTDSKRIRVIDIEEPHVYIVNIDTSSAMPRKELYSSLTTDIKQGELLAISDPYAKMISEGDLTEVQIRKREEDWETIQKYCVPNMQDLLRKQGRENKIIEVVRDSNLGKTKIKKLLTRYWQRGMTKNAMLPDYSNSGGKGKTKALTKEKVGRPRRVNLNNEYQTGINITEEVKVQIEHVINKYYRKKNNYSLKDVYNFMLRDFYSDRYKENGELKYRIWDATRTPSYHQFYYWFKKLEDPKKDIQFRKSTKEYELKHRPILGNSKSETNGPGTRFQIDATIADIYLVSSLDVNKVIGRPVIYAVLDVYSRIITGLYVGLEGPSWIGAMMALDNMVADKVEFCKQYGIDITPEQWPTHHLPEIIIADRGEFEGYSVDNLINNLNIKIENTTAYRGDLKGIVERKFRTFNGKLKQKAPGAIQKEYRERGDQDYRLNATLNLKEFTSLIITMALHHNQKVIDKYPVEKEMVAEGLVPTPINLWSWGIQNRTGRLRTIDRNILRLNVLPRGKATISRAGIKFKNLLYGSQRAIEEDWYLKLKNRSVEVVYDPRHVEKIYIPHDNGMDFETCILLEPSQQYKEDLLEEIVFQQQLRNELEEIERTNQIQLTVNTDAAMEEIIKNAVKNKKQSYNQPTSKKAKIASIRDNKDVEKQLNRESEKFDLSPDKVSESAEVIDFATKEKVDETPPKKSSSRLMQKLKKKRDEEFGKNK
>NZ_CP017090.1|WP_095236857.1|2258245_2259910_-|ATP-binding-protein
MVVLKGEFEKGTYKEQPLSEYTNNPFIEALPAIFSEDDVLERFMVTPRISRQDKLSATNIRYHVLKRVRNFIQPLPIHFEVERRLSTLIRRSYLARNPLDITFLERIRVLHELREEETTHKYIDERLDYIRSTADSLSIIGISGIGKTTAIERLLLMYPQVIKHEEYKGQPFNRTQIVWLKIDCPYDGSLSTLCKSFFKAIDDLLGTRYLEKFGYLNRVTSTMLLHMTSLASMYGIGVLVIDEIQHLLHSKNDQEEMLNFFVTLSNTVGIPTVLIGTSKAQKLFKGNFRQARRAASDGAIIWDRMAENSEEWEFFLETLWELQCLKTYSELTEELKKSFYYECQGITAVAMNLFILAQERALFDEGNPNEIITPQVLKKTAKEDMQTIQPMMTAIRTNNIADMMKYEDIMINLDEVMLNHKRNTEIAGRIQEAFKERQNRIEYKRQDMIENLSVEVAALGIFDSLKENDIKKLVQKIVEENSLDTEFNQLKSDAIQQAIALNQQKKDQKAKAKVKNVEVLPLLKLRKQALEKKQHPYELLKANGYIKKPLKEFY
>NZ_CP017090.1|WP_011867747.1|2256365_2258234_-|hypothetical-protein
MLPFFTDPYPDELIYSAIARYHFYSGNIDYKDTLEEVFQSRSVIPSLEIGSHFDALAQQIGNRYSVESLLAKHTIYPFYAPFLSKQRQQEILWDVQGDGKGLYTRLGMIAGGICKKDGLYYCSQCAKGDIDRYGEPYIHREHQLQGIDLCAHHYLQLKKYPDEFTEHSRIKFIRFEVQKMDLSVIQEVVYPERFDIQVNLATMAYQLLNVDIVVFSREEIFKRYQMLLKEKNLITTSNQVRQKELFDAFQVNFPKGFLEKYESNFNGEDEHNWLKVLTRNEKRHVHPLRHLFFLYFLGKDVEELFRVREDLGPFGKGPWPCLNKAADHYKQLVISNVKITRDFKTTAPIGTFECSCGYIYARKGPDKSSEDKYHIGRVKVFGATWMDKLRVLASNKNLSIRAMAEMLGVDSKTVKNYLSAGGKKEKIKNKVNSPMLQQYRTQLLEGIQQFPDDSRTQIRERFKREYMYLYRHDKKWLFNNLPINQIKGKPKATVDWESRDCEYYSKIKRLYEELIMLDKPVRITISVIGKRLGILSNLEKHLDKLPQTKKLLTDVTETTQQFQIRRCCTIINQMLREREPVSLWKVQRIGAVKSHHFYEIKPYLEAYINMKQEVDNYELTTS
>NZ_CP017090.1|WP_011867746.1|2254852_2256385_-|hypothetical-protein
MSSQQVKIKWPFKKGEKARLIWIGDPFRNNNKMMLHAYFRARGVTEKILMDWGTLPCLAIQHYYSDGVITTSQPPQGVQEVDITIYPNRVQYYEKLWNVHGSNDPATSRSFIFSFEGKNVILPVIEVLRSILAPNGFLLYRLFESNSFPQFFTETYEPNKIHLSFSSLYELKYTRTAFIYQLVWLLTNRDLRHVYESIAFTWLQEQTLKFEWTFTQPITVTARIKEDQNTWTVLQIVNVKNKYIPYENISISHPEIRDNEKSKEAKKYTYRSLNKKDGEGGFTLDEQVDGATEDFDFVQMNQLGHEYTSVPKVKQVKLGSTKQRLEEDENTKRYYGDDHYIRSTADSGGQQLARGLEHQMLHEIKAQGEIQDFINVLKVLEQYPEVKAIRAFTDVLPESVGHRKYTKLSDGITKRSYIIAEVYMMNGNHFNIIEVERERRSLSTLILSSSSKQNWSAICNYILLNLVNASGNWTRKSLNSINTKGIKIEKTKHSSKGVQHRAGILLGKLL
>NZ_CP017090.1|WP_000521495.1|2278840_2280196_-|phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK
>NZ_CP017090.1|WP_000894032.1|2280222_2281155_-|YbbR-like-domain-containing-protein
MLESKWGLRFIAFLLALFFFLSVNNVFGNIFNTGNLGQKSSKTIQDVPVEILYNTKDLHLTKAPETVNVTISGPQSKIIKIENPEDLRVVIDLSNAKAGKYQEKYQVKGLADDIHYSVKPKLANITLENKVTKKMTVQPDVSQSDIDPLYKITKQEVSPQTVKVTGGEEQLNDIAYLKATFKTNKKINGDTKDVAEVTAFDKKLNKLNVSIQPNEVNLQVKVEPFSKKVKVNVKQKGSLADDKELSSIDLEDKEIEIFGSRDDLQNISEVDAEVDLDGISESTEKTVKINLPEHVTKAQPSETKAYINVK
>NZ_CP017090.1|WP_000347896.1|2281156_2281966_-|TIGR00159-family-protein
MDFSNFFQNLSTLKIVTSILDLLIVWYVLYLLITVFKGTKAIQLLKGILVIVIGQQISMILNLTATSKLFDIVIQWGVLALIVIFQPEIRRALEQLGRGSFLKRYTSNTYSKDEEKLIQSVSKAVQYMAKRRIGALIVFEKETGLQDYIETGIAMDSNISQELLINVFIPNTPLHDGAMIIQGTKIAAAASYLPLSDSPKISKSLGTRHRAAVGISEVSDAFTVIVSEETGDISVTFDGKLRRDISNEIFEELLAEHWFGTRFQKKGVK
>NZ_CP017090.1|WP_000167867.1|2282154_2283063_-|arginase
MTKTKAIDIIGAPSTFGQRKLGVDLGPTAIRYAGLISRLKQLDLDVYDKGDIKVPAVNIEKFHSEQKGLRNYDEIIDVNQKLNKEVSASIENNRFPLVLGGDHSIAVGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNSNVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVDGVHLSLDVDALDPLETPGTGTRVLGGLSYRESHFALELLHQSHLISSMDLVEVNPLIDSNNHTAEQAVSLVGTFFGETLL
>NZ_CP017090.1|WP_000958531.1|2289301_2290366_-|P-loop-NTPase
MLTVDQVKELVGEIKDPIIDVPLKETEGIVEVSIKEEKEHVSVKLAMAQLGGAPQLDLQMAVVNALKENGAKTVGIRFETLPEEKVNQFKPKEENKPKTIEGLLSQNNPVEFIAIASGKGGVGKSTVAVNLAVALAREGKKVGLVDADIYGFSVPDMMGIDEKPGIKGKEVIPVERHGVKVISMAFFVEENAPVIWRGPMLGKMLTNFFTEVKWGDIEYLILDLPPGTGDVALDVHTMLPSSKEIIVTTPHPTAAFVAARAGAMAKHTDHSILGVIENMSYFESKETGNKEYVFGKGGGTKLADELNTQLLGELPLEQPSWNPKDFAPSIYQSDDRLGKIYSSIAQKVIAATNK
>NZ_CP017090.1|WP_001141007.1|2290513_2291956_-|multidrug-efflux-MFS-transporter-LmrS
MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLVNGVMIPLTAYLMDRIKTRPLYLAAMGTFLLGSIVAALAPNFGVLMLARVIQAMGAGVLMPLMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIALVAFVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALIISMVIIYLFIRRQFNITNVLLNLRVFKNRTFALCTISSMIIMMSMVGPALLIPLYVQNSLSLSALLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYLIVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFGAKIFLSTSPSHLTATEIKQQSIAIGVDISFAFVAVLVMAAYVIALFIREPKEIESNRRKF
>NZ_CP017090.1|WP_000636857.1|2292278_2292752_-|multidrug-efflux-transporter-SepA
MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
>NZ_CP017090.1|WP_001237506.1|2292850_2294194_-|MFS-transporter
MRLKSIITVIALILIMFMSAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLSRFKIIYVAIAGLLLFSIGSFMCGLSTNFTMLIISRVIQGFGSGVLMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVIWTFHFPEEETVAKSKFDTKGLTLFYVFIGLIMFALLNQQLLLLNFLSFILAIVVAMCLFKVEKHVSSPFLPVVEFNRSITLVFITDLLTAICLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHRIEAKLSRKVIYLLSFTLLLVSSIIISFGIKLPVLIAFVLILAGLSFGYIYTKDSVIVQEETSPLQMKKMMSFYGLTKNLGASIGSTIMGYLYAIQSGIFGPNLHNVLSAVAVISIGLIVLWVVFFKEQSSQSKE
>NZ_CP017090.1|WP_000047255.1|2294370_2295054_-|hemolysin-III-family-protein
MSKSTKKSNDTIVETFKDIIPLSFGEEIGNAASHGVAALLTLLVLPYAAVHSYIAHGTLASVSMSIYVISIFMMFISSTIYHSMQNETPHKYILRIIDHSMIYVAISGTYTPILLTVVGGWIGWTVFILLWGTTLWGILYKSIAVKVNQKLSLIVYLVMGWVGIILLPIIFIRTSWIFILFIFLGGVSYTIGAWFYAQKNRPYFHMIWHIFIVIASLLHLIAILYFM
>NZ_CP017090.1|WP_000884735.1|2295072_2296260_-|UDPGP-type-1-family-protein
MLDKNQLAKYKQDHLCEYEKIMSNNEKEALEEKVASLDLDFIAKLYNDLYINKKTIDDVSAVSEVKYDIKSQMSDDEIKRLEEQGLQAIKEGQFAVLLMAGGQGTRLGYKGPKGSFEIEGVSLFELQANQLKTLNHQSGHTIQWYIMTSDINHEETLAYFEAHSYFGYDQEAIHFFKQDNIVALSEEGKLILNQQGRIMETPNGNGGVFKSLDKAGYLEEMSNNGVKYIFLNNIDNVLVKVLDPLFAGFTVEHDYDITSKTIQPKPGESVGRLVNVDCKDTVLEYSELDPEVANQFNNANIGIHAFKLGFILNAVNRELPYHLAIKNLKQLDENFGVIEQPTLKFELFYFDIFTYGTSFVTLQVPREEEFSPLKNKEGKDSVATATEDLRRMGLI

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Crispr_ID: NZ_CP017090_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017090_11

2379449-2379529

Orphan

Consensus_repeat	Method
TCTATGTTGGGGCCCCGCCAACTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017090_11

>merge|NZ_CP017090|11|2379449-2379529|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTG

>NZ_CP017090|11|10|2379449-2379529|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTG	CACATTATTGTAAGCTGACTTTCTGTCAGCT
TCTGTGTTGGGGCCCCGCCAACTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017090.1\|WP_000503822.1\|2384319_2384826_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NZ_CP017090.1\|WP_000808495.1\|2381559_2382006_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NZ_CP017090.1\|WP_000230173.1\|2379672_2380695_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NZ_CP017090.1\|WP_001549681.1\|2375830_2376082_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000592307.1\|2370892_2374060_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP017090.1\|WP_000134526.1\|2383823_2384318_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_CP017090.1\|WP_001792132.1\|2379221_2379407_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000051210.1\|2369982_2370147_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_001161085.1\|2370391_2370709_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017090.1\|WP_000602950.1\|2382019_2382505_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NZ_CP017090.1\|WP_000413862.1\|2374176_2375442_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NZ_CP017090.1\|WP_000184404.1\|2377432_2378644_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NZ_CP017090.1\|WP_000600967.1\|2376073_2376838_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NZ_CP017090.1\|WP_000076930.1\|2384856_2385861_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|181084
NZ_CP017090.1\|WP_000866971.1\|2381320_2381554_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NZ_CP017090.1\|WP_000066900.1\|2378745_2379096_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NZ_CP017090.1\|WP_000259717.1\|2382501_2383761_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP017090.1\|WP_000913024.1\|2386030_2386636_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NZ_CP017090.1\|WP_000643986.1\|2380714_2381314_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NZ_CP017090.1\|WP_000951058.1\|2376999_2377440_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670

Protein	Function_ID	Function_description	E-value
NZ_CP017090.1\|WP_000503822.1\|2384319_2384826_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	2.42221e-64
NZ_CP017090.1\|WP_000643986.1\|2380714_2381314_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	2.15389e-66
NZ_CP017090.1\|WP_000230173.1\|2379672_2380695_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NZ_CP017090.1\|WP_000592307.1\|2370892_2374060_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP017090.1\|WP_000134526.1\|2383823_2384318_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.93711e-97
NZ_CP017090.1\|WP_000602950.1\|2382019_2382505_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	9.59347e-51
NZ_CP017090.1\|WP_000413862.1\|2374176_2375442_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	1.81413e-143
NZ_CP017090.1\|WP_000184404.1\|2377432_2378644_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.92881e-73
NZ_CP017090.1\|WP_000600967.1\|2376073_2376838_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NZ_CP017090.1\|WP_000076930.1\|2384856_2385861_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	6.83722e-133
NZ_CP017090.1\|WP_000866971.1\|2381320_2381554_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	8.16473e-25
NZ_CP017090.1\|WP_000066900.1\|2378745_2379096_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NZ_CP017090.1\|WP_000259717.1\|2382501_2383761_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	4.50966e-159
NZ_CP017090.1\|WP_000913024.1\|2386030_2386636_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.78595e-116
NZ_CP017090.1\|WP_000808495.1\|2381559_2382006_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	6.99133e-58
NZ_CP017090.1\|WP_000951058.1\|2376999_2377440_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.35323e-15

>NZ_CP017090.1|WP_001792132.1|2379221_2379407_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNDLECDINVKEPLKINYVVIFGSGTEITFSQNLFR
>NZ_CP017090.1|WP_000066900.1|2378745_2379096_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NZ_CP017090.1|WP_000184404.1|2377432_2378644_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFFVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETDVINKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NZ_CP017090.1|WP_000951058.1|2376999_2377440_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NZ_CP017090.1|WP_000600967.1|2376073_2376838_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NZ_CP017090.1|WP_001549681.1|2375830_2376082_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLVIIHMGILAHSTYVYLY
>NZ_CP017090.1|WP_000413862.1|2374176_2375442_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYILNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NZ_CP017090.1|WP_000592307.1|2370892_2374060_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHVDGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NZ_CP017090.1|WP_001161085.1|2370391_2370709_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NZ_CP017090.1|WP_000051210.1|2369982_2370147_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDLEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NZ_CP017090.1|WP_000230173.1|2379672_2380695_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NZ_CP017090.1|WP_000643986.1|2380714_2381314_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNIYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NZ_CP017090.1|WP_000866971.1|2381320_2381554_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NZ_CP017090.1|WP_000808495.1|2381559_2382006_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVIEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NZ_CP017090.1|WP_000602950.1|2382019_2382505_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKTHGYTVATIKHHGHAKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRDEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NZ_CP017090.1|WP_000259717.1|2382501_2383761_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NZ_CP017090.1|WP_000134526.1|2383823_2384318_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
>NZ_CP017090.1|WP_000503822.1|2384319_2384826_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFVTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NZ_CP017090.1|WP_000076930.1|2384856_2385861_-|molybdopterin-biosynthesis-protein-MoeB
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDGCIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSDCTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NZ_CP017090.1|WP_000913024.1|2386030_2386636_-|ATP-binding-cassette-domain-containing-protein
MLKINVKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTTKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSKHIDQLIQTLNINHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP017090_4	4.1\|835754\|32\|NZ_CP017090\|CRISPRCasFinder	835754-835785	32	NZ_CP017090.1	90071-90102	0	1.0
NZ_CP017090_4	4.1\|835754\|32\|NZ_CP017090\|CRISPRCasFinder	835754-835785	32	NZ_CP017090.1	872200-872231	0	1.0
NZ_CP017090_4	4.1\|835754\|32\|NZ_CP017090\|CRISPRCasFinder	835754-835785	32	NZ_CP017090.1	1717923-1717954	0	1.0
NZ_CP017090_4	4.1\|835754\|32\|NZ_CP017090\|CRISPRCasFinder	835754-835785	32	NZ_CP017090.1	2125378-2125409	0	1.0
NZ_CP017090_4	4.1\|835754\|32\|NZ_CP017090\|CRISPRCasFinder	835754-835785	32	NZ_CP017090.1	2545730-2545761	0	1.0
NZ_CP017090_8	8.1\|2101326\|34\|NZ_CP017090\|CRISPRCasFinder	2101326-2101359	34	NZ_CP017090.1	823077-823110	0	1.0
NZ_CP017090_8	8.1\|2101326\|34\|NZ_CP017090\|CRISPRCasFinder	2101326-2101359	34	NZ_CP017090.1	1176333-1176366	0	1.0
NZ_CP017090_4	4.1\|835754\|32\|NZ_CP017090\|CRISPRCasFinder	835754-835785	32	NZ_CP017090.1	1388036-1388067	1	0.969
NZ_CP017090_5	5.1\|871894\|34\|NZ_CP017090\|CRISPRCasFinder	871894-871927	34	NZ_CP017090.1	1387958-1387991	1	0.971
NZ_CP017090_6	6.1\|1703280\|33\|NZ_CP017090\|CRISPRCasFinder	1703280-1703312	33	NZ_CP017090.1	188880-188912	1	0.97
NZ_CP017090_6	6.1\|1703280\|33\|NZ_CP017090\|CRISPRCasFinder	1703280-1703312	33	NZ_CP017090.1	828519-828551	1	0.97
NZ_CP017090_6	6.1\|1703280\|33\|NZ_CP017090\|CRISPRCasFinder	1703280-1703312	33	NZ_CP017090.1	1387959-1387991	1	0.97
NZ_CP017090_8	8.1\|2101326\|34\|NZ_CP017090\|CRISPRCasFinder	2101326-2101359	34	NZ_CP017090.1	1836267-1836300	1	0.971
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	835704-835734	1	0.968
NZ_CP017090_7	7.2\|1737791\|22\|NZ_CP017090\|PILER-CR	1737791-1737812	22	NZ_CP017090.1	2101271-2101292	2	0.909
NZ_CP017090_7	7.2\|1737791\|22\|NZ_CP017090\|PILER-CR	1737791-1737812	22	NZ_CP017090.1	2101388-2101409	2	0.909
NZ_CP017090_8	8.1\|2101326\|34\|NZ_CP017090\|CRISPRCasFinder	2101326-2101359	34	NZ_CP017090.1	1392332-1392365	2	0.941
NZ_CP017090_8	8.1\|2101326\|34\|NZ_CP017090\|CRISPRCasFinder	2101326-2101359	34	NZ_CP017090.1	2820550-2820583	2	0.941
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	90077-90107	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	387682-387712	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	655335-655365	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	872206-872236	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	1079404-1079434	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	1181821-1181851	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	1387917-1387947	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	1476350-1476380	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	1476466-1476496	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	1717918-1717948	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	2040169-2040199	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	2368673-2368703	2	0.935
NZ_CP017090_11	11.1\|2379474\|31\|NZ_CP017090\|CRISPRCasFinder	2379474-2379504	31	NZ_CP017090.1	2545736-2545766	2	0.935

1. spacer 4.1|835754|32|NZ_CP017090|CRISPRCasFinder matches to position: 90071-90102, mismatch: 0, identity: 1.0

aacttgcacattattgtaagctgactttccgc	CRISPR spacer
aacttgcacattattgtaagctgactttccgc	Protospacer
********************************

2. spacer 4.1|835754|32|NZ_CP017090|CRISPRCasFinder matches to position: 872200-872231, mismatch: 0, identity: 1.0

aacttgcacattattgtaagctgactttccgc	CRISPR spacer
aacttgcacattattgtaagctgactttccgc	Protospacer
********************************

3. spacer 4.1|835754|32|NZ_CP017090|CRISPRCasFinder matches to position: 1717923-1717954, mismatch: 0, identity: 1.0

aacttgcacattattgtaagctgactttccgc	CRISPR spacer
aacttgcacattattgtaagctgactttccgc	Protospacer
********************************

4. spacer 4.1|835754|32|NZ_CP017090|CRISPRCasFinder matches to position: 2125378-2125409, mismatch: 0, identity: 1.0

aacttgcacattattgtaagctgactttccgc	CRISPR spacer
aacttgcacattattgtaagctgactttccgc	Protospacer
********************************

5. spacer 4.1|835754|32|NZ_CP017090|CRISPRCasFinder matches to position: 2545730-2545761, mismatch: 0, identity: 1.0

aacttgcacattattgtaagctgactttccgc	CRISPR spacer
aacttgcacattattgtaagctgactttccgc	Protospacer
********************************

6. spacer 8.1|2101326|34|NZ_CP017090|CRISPRCasFinder matches to position: 823077-823110, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

7. spacer 8.1|2101326|34|NZ_CP017090|CRISPRCasFinder matches to position: 1176333-1176366, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

8. spacer 4.1|835754|32|NZ_CP017090|CRISPRCasFinder matches to position: 1388036-1388067, mismatch: 1, identity: 0.969

aacttgcacattattgtaagctgactttccgc	CRISPR spacer
aacttgcacattattgtaaactgactttccgc	Protospacer
*******************.************

9. spacer 5.1|871894|34|NZ_CP017090|CRISPRCasFinder matches to position: 1387958-1387991, mismatch: 1, identity: 0.971

attgagaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
****.*****************************

10. spacer 6.1|1703280|33|NZ_CP017090|CRISPRCasFinder matches to position: 188880-188912, mismatch: 1, identity: 0.97

attgggaatccaatttctctgtgttggggccca	CRISPR spacer
attgggaatccaatttctctttgttggggccca	Protospacer
******************** ************

11. spacer 6.1|1703280|33|NZ_CP017090|CRISPRCasFinder matches to position: 828519-828551, mismatch: 1, identity: 0.97

attgggaatccaatttctctgtgttggggccca	CRISPR spacer
attggaaatccaatttctctgtgttggggccca	Protospacer
*****.***************************

12. spacer 6.1|1703280|33|NZ_CP017090|CRISPRCasFinder matches to position: 1387959-1387991, mismatch: 1, identity: 0.97

attgggaatccaatttctctgtgttggggccca	CRISPR spacer
attgggaatccaatttctctttgttggggccca	Protospacer
******************** ************

13. spacer 8.1|2101326|34|NZ_CP017090|CRISPRCasFinder matches to position: 1836267-1836300, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctttgtgttgg	Protospacer
*************************.********

14. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 835704-835734, mismatch: 1, identity: 0.968

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgtcagct	Protospacer
***********************.*******

15. spacer 7.2|1737791|22|NZ_CP017090|PILER-CR matches to position: 2101271-2101292, mismatch: 2, identity: 0.909

tgaaattggggttccaatttct	CRISPR spacer
tgaaattgggaatccaatttct	Protospacer
**********. **********

16. spacer 7.2|1737791|22|NZ_CP017090|PILER-CR matches to position: 2101388-2101409, mismatch: 2, identity: 0.909

tgaaattggggttccaatttct	CRISPR spacer
tgaaattgggaatccaatttct	Protospacer
**********. **********

17. spacer 8.1|2101326|34|NZ_CP017090|CRISPRCasFinder matches to position: 1392332-1392365, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtggaatttcttatcgaaattctctgtgttgg	Protospacer
****.********* *******************

18. spacer 8.1|2101326|34|NZ_CP017090|CRISPRCasFinder matches to position: 2820550-2820583, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctttttgttgg	Protospacer
*************************.* ******

19. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 90077-90107, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

20. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 387682-387712, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

21. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 655335-655365, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

22. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 872206-872236, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

23. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 1079404-1079434, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

24. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 1181821-1181851, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

25. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 1387917-1387947, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

26. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 1476350-1476380, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

27. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 1476466-1476496, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

28. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 1717918-1717948, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

29. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 2040169-2040199, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

30. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 2368673-2368703, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

31. spacer 11.1|2379474|31|NZ_CP017090|CRISPRCasFinder matches to position: 2545736-2545766, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP017090_10	10.1\|2271448\|34\|NZ_CP017090\|CRISPRCasFinder	2271448-2271481	34	JN882286	Cronobacter phage vB_CsaP_GAP52, complete genome	23034-23067	8	0.765
NZ_CP017090_10	10.1\|2271448\|34\|NZ_CP017090\|CRISPRCasFinder	2271448-2271481	34	CP030544	Staphylococcus aureus strain ER04166.3 plasmid unnamed2, complete sequence	7567-7600	8	0.765

1. spacer 10.1|2271448|34|NZ_CP017090|CRISPRCasFinder matches to JN882286 (Cronobacter phage vB_CsaP_GAP52, complete genome) position: , mismatch: 8, identity: 0.765

ttgcatatctttagctttattgtttgcaactggg	CRISPR spacer
ttgcatatctttagctttatagcttttatatgct	Protospacer
******************** *.** .*  **

2. spacer 10.1|2271448|34|NZ_CP017090|CRISPRCasFinder matches to CP030544 (Staphylococcus aureus strain ER04166.3 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

ttgcatatctttagctttattgtttgcaactggg	CRISPR spacer
ttgaataactttagctttattgttataaacagta	Protospacer
*** *** ****************   *** * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12545 : 70775

Bacillus_phage(33.33%)

protease,tRNA,transposase,integrase

attL 58643:58702|attR 73237:77904

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000884332.1\|12545_13832_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	4.5e-88	50.9
WP_000190726.1\|14482_15178_+	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_000628051.1\|15174_15504_+	AzlD domain-containing protein	NA	NA	NA	NA
WP_000186490.1\|15866_16835_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_001800884.1\|17127_18066_+	YybS family protein	NA	NA	NA	NA
WP_001081640.1\|18080_20048_+	cyclic-di-AMP phosphodiesterase GdpP	NA	NA	NA	NA
WP_000864305.1\|20044_20491_+	50S ribosomal protein L9	NA	NA	NA	NA
WP_000375647.1\|20522_21923_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	5.4e-111	48.1
WP_000095328.1\|22200_23484_+	adenylosuccinate synthase	L7Y4J5	Megavirus	1.8e-68	34.6
WP_000101976.1\|24686_25388_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.5e-42	39.2
WP_000871607.1\|25400_27227_+	cell wall metabolism sensor histidine kinase WalK	W8CYF6	Bacillus_phage	1.6e-30	31.3
WP_001060140.1\|27219_28554_+	hypothetical protein	NA	NA	NA	NA
WP_001104165.1\|28554_29343_+	hypothetical protein	NA	NA	NA	NA
WP_000088649.1\|29731_30532_+	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	1.0e-37	35.9
WP_000645787.1\|30758_33077_+	LPXTG-anchored adenosine synthase AdsA	NA	NA	NA	NA
WP_000704775.1\|33444_33924_+	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	NA	NA	NA	NA
WP_000566670.1\|34245_35502_+	DUF3578 domain-containing protein	NA	NA	NA	NA
WP_001282728.1\|35916_36156_+	hypothetical protein	NA	NA	NA	NA
WP_001106057.1\|36187_36862_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	2.6e-127	99.1
WP_020444595.1\|36897_37287_+	hydroxymethylglutaryl-CoA synthase family protein	NA	NA	NA	NA
WP_000958858.1\|38163_38907_+	glycerophosphoryl diester phosphodiesterase	NA	NA	NA	NA
WP_000872606.1\|39003_39432_+	MaoC family dehydratase	NA	NA	NA	NA
WP_001801873.1\|39477_41487_-	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	NA	NA	NA	NA
WP_001549960.1\|41583_42570_+	beta-lactam sensor/signal transducer MecR1	NA	NA	NA	NA
WP_001549961.1\|42541_42802_+	DUF3387 domain-containing protein	NA	NA	NA	NA
WP_001092189.1\|44451_44958_-	DUF1643 domain-containing protein	NA	NA	NA	NA
WP_000700851.1\|44972_45284_-	DUF960 domain-containing protein	NA	NA	NA	NA
WP_001067160.1\|45285_45378_-	hypothetical protein	NA	NA	NA	NA
WP_000849672.1\|45370_45721_-	hypothetical protein	NA	NA	NA	NA
WP_001186608.1\|46242_47871_-	recombinase RecB	A0A0S2SXR4	Bacillus_phage	5.4e-46	31.4
WP_000815640.1\|47892_49242_-	recombinase RecA	Q9T200	Bacillus_phage	1.4e-18	24.8
WP_000122620.1\|49475_51263_-	DUF927 domain-containing protein	NA	NA	NA	NA
WP_001036438.1\|51262_51553_-	hypothetical protein	NA	NA	NA	NA
WP_000613248.1\|51691_52741_+	hypothetical protein	NA	NA	NA	NA
WP_000554504.1\|53303_54794_+	ATPase AAA	NA	NA	NA	NA
WP_001549968.1\|56674_57046_+	HNH endonuclease	NA	NA	NA	NA
WP_000673114.1\|57174_57795_+	hypothetical protein	NA	NA	NA	NA
58643:58702	attL	NA	NA	NA	NA
WP_031590764.1\|59241_59472_+	hypothetical protein	NA	NA	NA	NA
WP_031590768.1\|59479_59686_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_031590769.1\|60082_61138_+	DUF418 domain-containing protein	NA	NA	NA	NA
WP_031775117.1\|61163_61886_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_031590773.1\|62085_63180_+\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	6.9e-37	33.9
WP_124216780.1\|65838_66177_+	hypothetical protein	NA	NA	NA	NA
WP_078098743.1\|66220_66322_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_078098742.1\|66340_66724_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A2I6AZV9	Macacine_betaherpesvirus	6.4e-14	37.4
WP_078098741.1\|66707_66929_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_031590800.1\|67030_67471_-	hypothetical protein	NA	NA	NA	NA
WP_031590773.1\|68758_69853_-\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	6.9e-37	33.9
WP_031775117.1\|70052_70775_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
73237:77904	attR	NA	NA	NA	NA

DBSCAN-SWA_2

758730 : 766551

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|758730_759786_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_088401680.1\|759785_760472_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|760446_760920_-	DoxX family protein	NA	NA	NA	NA
WP_001093562.1\|761262_761703_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000604990.1\|761982_762567_-	hypothetical protein	NA	NA	NA	NA
WP_001062972.1\|762665_763379_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|763382_763802_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|763803_764472_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604514.1\|764822_765416_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_001217796.1\|765399_766551_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	6.0e-23	35.7

DBSCAN-SWA_3

778522 : 793163

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663030.1\|778522_779581_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7
WP_000197262.1\|779919_780462_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429006.1\|781340_782258_-	lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.0
WP_031760357.1\|782348_782450_+	hypothetical protein	NA	NA	NA	NA
WP_000193751.1\|782527_784033_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930014.1\|784373_784874_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_088401681.1\|784893_785760_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|786560_786959_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855514.1\|786921_789027_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|789144_790116_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|790296_790452_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|790490_791462_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245577.1\|791448_792405_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616840.1\|792401_793163_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	6.5e-18	31.6

DBSCAN-SWA_4

880281 : 934366

Staphylococcus_phage(76.27%)

tail,terminase,holin,transposase,integrase,plate,capsid,portal,head

attL 875588:875603|attR 931253:931268

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
875588:875603	attL	NA	NA	NA	NA
WP_000807663.1\|880281_881523_+	cysteine desulfurase	Q2XUY6	environmental_halophage	8.2e-111	44.8
WP_001010508.1\|881512_881977_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_001074405.1\|882127_883525_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_001145730.1\|883592_884642_-\|integrase	site-specific integrase	A0A0H4ISP4	Staphylococcus_phage	2.7e-203	100.0
WP_016187262.1\|884708_884951_-	hypothetical protein	NA	NA	NA	NA
WP_021285964.1\|884961_885945_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000142628.1\|885996_886671_-	LexA family transcriptional regulator	A0A1W6JPS3	Staphylococcus_phage	2.3e-115	92.0
WP_016187264.1\|886862_887102_+	helix-turn-helix transcriptional regulator	A0A2H4J3I3	uncultured_Caudovirales_phage	9.4e-32	88.6
WP_021285963.1\|887270_887507_-	hypothetical protein	Q4ZBN3	Staphylococcus_phage	8.7e-38	97.4
WP_001576117.1\|887571_888312_+	phage antirepressor protein	Q8SDM9	Staphylococcus_phage	1.8e-134	99.6
WP_001555746.1\|888336_888552_+	hypothetical protein	E9LT76	Staphylococcus_phage	5.0e-32	98.6
WP_000977381.1\|888823_889045_+	hypothetical protein	A0A0F6N3I2	Staphylococcus_phage	1.5e-31	100.0
WP_000048124.1\|889037_889199_+	DUF1270 family protein	C7F7L3	Staphylococcus_phage	1.9e-20	100.0
WP_000163429.1\|889301_889604_+	DUF2482 family protein	A0A0K1LKL3	Staphylococcus_phage	2.6e-47	100.0
WP_021285962.1\|889608_889869_+	DUF1108 family protein	Q9MBS4	Staphylococcus_prophage	2.0e-43	98.8
WP_016187438.1\|889883_890363_+	siphovirus Gp157 family protein	Q9MBS3	Staphylococcus_prophage	3.4e-81	97.5
WP_001043063.1\|890362_891001_+	ERF family protein	Q9MBS2	Staphylococcus_prophage	1.7e-115	100.0
WP_016187439.1\|891000_891429_+	single-stranded DNA-binding protein	A0A2H4JHI1	uncultured_Caudovirales_phage	2.5e-59	98.6
WP_015980404.1\|891442_892138_+	hypothetical protein	Q9MBS0	Staphylococcus_prophage	2.3e-134	100.0
WP_000504986.1\|892109_892913_+	replication protein	Q9MBR9	Staphylococcus_prophage	1.5e-121	100.0
WP_000803049.1\|892922_893696_+	AAA domain-containing protein	C5I645	Staphylococcus_phage	3.0e-143	99.6
WP_001123688.1\|893863_894085_+	DUF3269 family protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
WP_031903462.1\|894504_894693_+	DUF3113 family protein	A0A1W6JPY2	Staphylococcus_phage	3.2e-27	100.0
WP_031903463.1\|894693_895053_+	phage protein	B2ZYW3	Staphylococcus_phage	1.2e-59	95.8
WP_031903464.1\|895052_895307_+	DUF3310 domain-containing protein	A7TWG9	Staphylococcus_phage	1.8e-41	97.6
WP_078099314.1\|895306_895555_+	hypothetical protein	M1T302	Staphylococcus_phage	2.4e-38	93.8
WP_071161935.1\|895618_895966_+	hypothetical protein	A0A1W6JPZ1	Staphylococcus_phage	6.5e-58	97.4
WP_000144708.1\|895962_896271_+	hypothetical protein	Q4ZBK6	Staphylococcus_phage	8.1e-52	100.0
WP_071161936.1\|896263_896518_+	DUF1024 family protein	M9NRI5	Staphylococcus_phage	7.2e-38	100.0
WP_078061234.1\|896480_896675_+	hypothetical protein	M1SVE4	Staphylococcus_phage	1.8e-25	98.4
WP_001066446.1\|896667_897174_+	hypothetical protein	Q4ZDP4	Staphylococcus_virus	3.8e-91	100.0
WP_000195770.1\|897210_897417_+	DUF1381 domain-containing protein	B7T0C2	Staphylococcus_virus	6.0e-19	95.6
WP_016187270.1\|897413_897617_+	hypothetical protein	B2ZYX5	Staphylococcus_phage	6.3e-29	92.5
WP_025176537.1\|897609_897783_+	transcriptional regulator	Q4ZBK0	Staphylococcus_phage	2.4e-21	98.2
WP_000989998.1\|897783_897930_+	hypothetical protein	A0A059T5A8	Staphylococcus_phage	2.2e-15	100.0
WP_000162701.1\|897953_898376_+	RinA family phage transcriptional activator	A0A0F6N3E5	Staphylococcus_phage	1.2e-74	100.0
WP_000594088.1\|898706_899201_+\|terminase	terminase	A0A0N9BAX3	Staphylococcus_phage	3.4e-84	100.0
WP_001037578.1\|899193_900417_+\|terminase	PBSX family phage terminase large subunit	A0A0N9BAX9	Staphylococcus_phage	7.5e-242	100.0
WP_016187272.1\|900413_901838_+\|portal	phage portal protein	M9NS48	Staphylococcus_phage	7.4e-273	100.0
WP_000184140.1\|901806_902757_+	hypothetical protein	M9NST7	Staphylococcus_phage	2.3e-177	100.0
WP_000440857.1\|902760_902994_+	hypothetical protein	M9NUJ2	Staphylococcus_phage	2.5e-37	100.0
WP_016187273.1\|903097_903682_+	DUF4355 domain-containing protein	M9NRJ1	Staphylococcus_phage	9.0e-76	100.0
WP_016187274.1\|903698_904613_+\|capsid	phage major capsid protein	M9NTC2	Staphylococcus_phage	3.4e-170	100.0
WP_016187275.1\|904773_905124_+	hypothetical protein	M9NST9	Staphylococcus_phage	1.4e-60	100.0
WP_021285837.1\|905135_905471_+\|head	phage head closure protein	M9NUJ3	Staphylococcus_phage	3.9e-60	100.0
WP_031903445.1\|905457_905871_+	HK97 gp10 family phage protein	A0A0N9BAY5	Staphylococcus_phage	3.0e-65	87.6
WP_031903446.1\|905883_906309_+	DUF3168 domain-containing protein	Q4ZBQ9	Staphylococcus_phage	4.4e-72	96.5
WP_000057585.1\|906309_906867_+	hypothetical protein	A0A059T675	Staphylococcus_phage	4.1e-102	100.0
WP_000134336.1\|906933_907446_+	hypothetical protein	A0A059T5B1	Staphylococcus_phage	5.4e-93	100.0
WP_025176538.1\|907490_907775_+	hypothetical protein	A0A059T626	Staphylococcus_phage	1.2e-44	96.8
WP_031903447.1\|907778_910664_+\|terminase	terminase	M9NRJ5	Staphylococcus_phage	0.0e+00	99.9
WP_021285834.1\|910678_911620_+\|tail	phage tail protein	Q4ZBQ4	Staphylococcus_phage	2.6e-181	99.0
WP_016187282.1\|911630_913517_+	hypothetical protein	M9NS58	Staphylococcus_phage	0.0e+00	100.0
WP_016187283.1\|913529_915428_+	hypothetical protein	M9NSU3	Staphylococcus_phage	0.0e+00	100.0
WP_016187284.1\|915427_917251_+\|plate	BppU family phage baseplate upper protein	M9NUJ5	Staphylococcus_phage	1.5e-299	100.0
WP_016187285.1\|917250_917628_+	DUF2977 domain-containing protein	M9NRJ7	Staphylococcus_phage	1.1e-61	100.0
WP_001800921.1\|917637_917811_+	XkdX family protein	A0A059T7K6	Staphylococcus_phage	1.3e-27	100.0
WP_021285833.1\|917851_918151_+	DUF2951 family protein	B7T0E7	Staphylococcus_virus	3.1e-40	89.9
WP_016187457.1\|918287_920162_+	CHAP domain-containing protein	Q4ZBX1	Staphylococcus_virus	0.0e+00	96.5
WP_016187458.1\|920174_920588_+\|plate	BppU family phage baseplate upper protein	M9NUJ6	Staphylococcus_phage	1.4e-75	100.0
WP_000354128.1\|920643_921081_+\|holin	phage holin	S4SVG2	Staphylococcus_phage	4.1e-73	99.3
WP_023180154.1\|921061_922507_+	CHAP domain-containing protein	Q4ZB16	Staphylococcus_virus	1.8e-295	99.8
WP_001190816.1\|923858_924500_+	hypothetical protein	Q4ZB11	Staphylococcus_virus	9.7e-116	100.0
WP_000274029.1\|925107_925422_-	hypothetical protein	NA	NA	NA	NA
WP_000582326.1\|925786_926827_+	HlyC/CorC family transporter	NA	NA	NA	NA
WP_000267236.1\|926840_927908_+	nitronate monooxygenase	NA	NA	NA	NA
WP_016170465.1\|928161_928245_+	hypothetical protein	NA	NA	NA	NA
WP_000608129.1\|928292_929141_+	DUF72 domain-containing protein	NA	NA	NA	NA
WP_000927632.1\|929153_929981_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_001241246.1\|930007_931327_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
931253:931268	attR	NA	NA	NA	NA
WP_000201875.1\|931410_932328_+	lipoyl synthase	NA	NA	NA	NA
WP_000598444.1\|932457_932841_+	YutD family protein	NA	NA	NA	NA
WP_001557163.1\|933046_934366_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

1080914 : 1089387

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861572.1\|1080914_1081397_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010413.1\|1081383_1082508_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174053.1\|1082511_1083216_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
WP_000848350.1\|1083215_1083479_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666806.1\|1083480_1084152_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_000032740.1\|1084144_1086334_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.5e-141	39.8
WP_000483720.1\|1086312_1087797_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.9e-45	31.7
WP_000030811.1\|1087789_1088818_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.4e-62	41.7
WP_000238669.1\|1088820_1089387_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1

DBSCAN-SWA_6

1530741 : 1617966

104

Staphylococcus_phage(72.73%)

tail,terminase,tRNA,holin,integrase,protease,capsid,plate,head,portal

attL 1567017:1567044|attR 1612360:1612387

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858779.1\|1530741_1532034_-\|tRNA	asparagine--tRNA ligase	M1PB22	Moumouvirus	8.7e-55	31.3
WP_000525078.1\|1532355_1535049_-	ATP-dependent helicase DinG	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000049921.1\|1535072_1536044_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000361540.1\|1536030_1537233_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	4.2e-35	43.3
WP_000690025.1\|1537237_1538380_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839926.1\|1538623_1538941_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_001827022.1\|1539276_1539957_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000154683.1\|1540028_1540616_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_000005212.1\|1540605_1541181_-	IDEAL domain-containing protein	G3MAV7	Bacillus_virus	2.1e-08	27.2
WP_000389524.1\|1541194_1542439_-	hypothetical protein	NA	NA	NA	NA
WP_000253231.1\|1542445_1543744_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776312.1\|1543753_1544818_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269921.1\|1544843_1546010_-	chorismate synthase	A0A291AU41	Pandoravirus	5.8e-34	31.8
WP_000789522.1\|1546395_1546596_-	hypothetical protein	NA	NA	NA	NA
WP_000442480.1\|1546804_1547254_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_001817755.1\|1547345_1548290_-	heptaprenyl diphosphate synthase subunit II	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774684.1\|1548306_1549032_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|1549034_1549607_-	heptaprenyl pyrophosphate synthase subunit A	NA	NA	NA	NA
WP_001043863.1\|1550037_1550310_-	DNA-binding protein HU	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161745.1\|1550480_1551479_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165530.1\|1551495_1552806_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133961.1\|1553027_1554203_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_001800578.1\|1554459_1554651_-	hypothetical protein	NA	NA	NA	NA
WP_001795818.1\|1554731_1554884_-	hypothetical protein	NA	NA	NA	NA
WP_000644391.1\|1554914_1555574_-	(d)CMP kinase	NA	NA	NA	NA
WP_000681757.1\|1555650_1556619_+	asparaginase	NA	NA	NA	NA
WP_001174258.1\|1556733_1557720_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_001792205.1\|1557880_1557997_-	hypothetical protein	NA	NA	NA	NA
WP_000069291.1\|1558121_1559582_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902099.1\|1559734_1561114_-	ATP-dependent DNA helicase RecQ	A0A2P1EM61	Moumouvirus	1.4e-55	33.6
WP_001163801.1\|1561103_1562057_-	hypothetical protein	NA	NA	NA	NA
WP_001151997.1\|1562164_1562413_+	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001186912.1\|1562518_1563064_-	ECF transporter S component	NA	NA	NA	NA
WP_000913227.1\|1563465_1564422_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001557351.1\|1564562_1564817_-	hypothetical protein	NA	NA	NA	NA
WP_000476354.1\|1564892_1565789_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000464818.1\|1566840_1567188_-	hypothetical protein	Q4ZCJ7	Staphylococcus_virus	3.0e-26	100.0
1567017:1567044	attL	NA	NA	NA	NA
WP_001190816.1\|1567292_1567934_-	hypothetical protein	Q4ZB11	Staphylococcus_virus	9.7e-116	100.0
WP_000385047.1\|1567948_1568611_-	hypothetical protein	Q4ZB12	Staphylococcus_virus	7.4e-119	100.0
WP_023180154.1\|1569286_1570732_-	CHAP domain-containing protein	Q4ZB16	Staphylococcus_virus	1.8e-295	99.8
WP_000354128.1\|1570712_1571150_-\|holin	phage holin	S4SVG2	Staphylococcus_phage	4.1e-73	99.3
WP_000466784.1\|1571285_1571585_-	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_000916021.1\|1571630_1571795_-	XkdX family protein	Q4ZCZ6	Staphylococcus_virus	4.9e-24	100.0
WP_001166598.1\|1571787_1572177_-	DUF2977 domain-containing protein	M9QYR4	Staphylococcus_phage	9.9e-63	99.2
WP_088401702.1\|1572176_1573643_-\|plate	BppU family phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	2.1e-270	98.8
WP_000429551.1\|1573642_1575553_-	minor structural protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	100.0
WP_000179860.1\|1575568_1575859_-	hypothetical protein	A0A2I6PF46	Staphylococcus_phage	2.1e-49	100.0
WP_000384474.1\|1575858_1577442_-	peptidase	A0A2I6PEQ5	Staphylococcus_phage	9.3e-309	100.0
WP_001190533.1\|1577450_1578275_-\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_088401703.1\|1578274_1584475_-\|tail	phage tail tape measure protein	A0A2K9VBQ5	Staphylococcus_phage	0.0e+00	99.7
WP_000438833.1\|1584488_1584647_-	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_000589165.1\|1584688_1585039_-	hypothetical protein	A0A2I6PDE6	Staphylococcus_phage	1.1e-55	100.0
WP_000169128.1\|1585096_1585552_-	Ig domain-containing protein	A0A2I6PF45	Staphylococcus_phage	1.3e-77	100.0
WP_000807536.1\|1585643_1586285_-\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_001028464.1\|1586319_1586715_-	DUF3168 domain-containing protein	A0A0K1LKC0	Staphylococcus_phage	1.7e-65	96.2
WP_000110015.1\|1586715_1587117_-	hypothetical protein	A0A0K1LL98	Staphylococcus_phage	4.0e-67	99.2
WP_000395498.1\|1587113_1587446_-	hypothetical protein	A0A2I6PES3	Staphylococcus_phage	4.1e-57	100.0
WP_000050973.1\|1587457_1587736_-\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_001142738.1\|1587804_1588968_-\|capsid	phage major capsid protein	M9QQM0	Staphylococcus_phage	4.2e-218	100.0
WP_031775146.1\|1588979_1589753_-\|protease	Clp protease ClpP	M1TAZ4	Staphylococcus_phage	7.8e-136	98.8
WP_001100669.1\|1589736_1590975_-\|portal	phage portal protein	A0A2K9VBP0	Staphylococcus_phage	6.9e-235	100.0
WP_015974521.1\|1590979_1592671_-\|terminase	terminase large subunit	Q9B0E3	Staphylococcus_virus	0.0e+00	100.0
WP_000778933.1\|1592660_1592966_-\|terminase	terminase	A0A2I6PEQ6	Staphylococcus_phage	2.9e-49	100.0
WP_000160693.1\|1593093_1593408_-	HNH endonuclease	A0A2I6PF37	Staphylococcus_phage	2.5e-56	100.0
WP_088401704.1\|1593564_1594002_-	transcriptional regulator	A0A2I6PEN3	Staphylococcus_phage	1.4e-73	95.9
WP_088401705.1\|1594014_1595382_-	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	3.3e-262	99.6
WP_031864035.1\|1595362_1595653_-	VRR-NUC domain-containing protein	A0A2I6PEN7	Staphylococcus_phage	1.1e-50	99.0
WP_001801650.1\|1595786_1595885_+	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	3.7e-11	100.0
WP_088401706.1\|1595993_1598441_-	hypothetical protein	Q4ZCG0	Staphylococcus_virus	0.0e+00	99.4
WP_031794940.1\|1598492_1598693_-	DUF1514 domain-containing protein	A0A2I6PF41	Staphylococcus_phage	3.8e-26	98.5
WP_000595213.1\|1598760_1598913_-	transcriptional activator RinB	B7T0I1	Staphylococcus_virus	1.2e-19	98.0
WP_031795553.1\|1598909_1599116_-	DUF1381 domain-containing protein	A0A2I6PDB6	Staphylococcus_phage	8.4e-29	95.6
WP_001066446.1\|1599152_1599659_-	hypothetical protein	Q4ZDP4	Staphylococcus_virus	3.8e-91	100.0
WP_078061234.1\|1599651_1599846_-	hypothetical protein	M1SVE4	Staphylococcus_phage	1.8e-25	98.4
WP_071161936.1\|1599808_1600063_-	DUF1024 family protein	M9NRI5	Staphylococcus_phage	7.2e-38	100.0
WP_000144708.1\|1600055_1600364_-	hypothetical protein	Q4ZBK6	Staphylococcus_phage	8.1e-52	100.0
WP_078099314.1\|1600770_1601019_-	hypothetical protein	M1T302	Staphylococcus_phage	2.4e-38	93.8
WP_088401707.1\|1601002_1601371_-	hypothetical protein	B2ZYW3	Staphylococcus_phage	1.1e-58	94.9
WP_001187234.1\|1601371_1601557_-	DUF3113 family protein	A0A1W6JPY2	Staphylococcus_phage	8.3e-28	100.0
WP_088401708.1\|1601556_1601712_-	transcriptional regulator	A0A2I6PDP0	Staphylococcus_phage	3.8e-18	92.2
WP_078099133.1\|1601723_1603676_-	DNA polymerase	A0A2I6PF18	Staphylococcus_phage	0.0e+00	99.5
WP_000645049.1\|1603744_1604302_-	DUF2815 family protein	A0A2K9VBT2	Staphylococcus_phage	1.3e-92	95.7
WP_000762532.1\|1604327_1605494_-	DUF2800 domain-containing protein	A0A2I6PDL4	Staphylococcus_phage	8.3e-222	100.0
WP_000985976.1\|1605490_1605853_-	hypothetical protein	A0A2I6PF03	Staphylococcus_phage	4.9e-56	100.0
WP_000174994.1\|1605867_1606191_-	hypothetical protein	A0A2I6PF12	Staphylococcus_phage	5.9e-53	100.0
WP_001285963.1\|1606269_1606431_-	DUF1270 family protein	A0A2I6PEZ9	Staphylococcus_phage	5.0e-21	100.0
WP_001124190.1\|1606443_1606707_-	helix-turn-helix domain-containing protein	A0A2I6PDM6	Staphylococcus_phage	1.1e-44	100.0
WP_001036302.1\|1606731_1606947_-	hypothetical protein	A0A2I6PDN5	Staphylococcus_phage	1.3e-32	100.0
WP_001128433.1\|1607001_1607367_+	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	2.4e-63	100.0
WP_001025401.1\|1607335_1607581_-	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_000642492.1\|1607636_1607846_+	hypothetical protein	W5R9J5	Staphylococcus_phage	1.2e-30	100.0
WP_000939498.1\|1607835_1607979_-	hypothetical protein	W5R8I6	Staphylococcus_phage	2.5e-16	100.0
WP_001115060.1\|1608066_1608258_-	helix-turn-helix transcriptional regulator	A0A2I6PEL6	Staphylococcus_phage	2.3e-28	100.0
WP_000429766.1\|1608418_1608748_+	helix-turn-helix transcriptional regulator	A0A2I6PEN2	Staphylococcus_phage	3.2e-54	100.0
WP_088401709.1\|1608760_1609222_+	toxin	A0A2I6PEK4	Staphylococcus_phage	1.1e-84	98.0
WP_000755721.1\|1609239_1609674_+	hypothetical protein	A0A2I6PEM0	Staphylococcus_phage	1.2e-24	100.0
WP_000449657.1\|1609702_1610098_+	hypothetical protein	A0A2I6PEJ7	Staphylococcus_phage	1.1e-69	99.2
WP_001795334.1\|1610187_1610334_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.2e-16	100.0
WP_031808062.1\|1610330_1610945_-	hypothetical protein	A0A2I6PEZ0	Staphylococcus_phage	8.8e-106	99.5
WP_088401710.1\|1611070_1612276_+\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	3.8e-222	99.8
WP_088401711.1\|1612318_1614346_-	hypothetical protein	B5WZK7	Staphylococcus_phage	1.4e-115	99.5
1612360:1612387	attR	NA	NA	NA	NA
WP_001557355.1\|1614338_1615265_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000987774.1\|1615508_1617260_-	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	2.2e-21	33.2
WP_000064078.1\|1617240_1617966_-	response regulator transcription factor	W8CYM9	Bacillus_phage	3.5e-45	43.0

DBSCAN-SWA_7

1752923 : 1761966

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1752923_1753442_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595011.1\|1753463_1755737_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
WP_000749795.1\|1755939_1758219_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1758493_1758754_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1758772_1759912_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_088401718.1\|1759934_1760960_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005768.1\|1760961_1761966_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_8

1898386 : 1960596

Staphylococcus_phage(95.65%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001050566.1\|1898386_1904947_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	6.1e-306	98.3
WP_088401723.1\|1905272_1905584_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.4e-51	98.1
WP_154702192.1\|1905605_1908020_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.3
WP_001025067.1\|1908310_1909492_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	7.3e-218	99.7
WP_000526539.1\|1909601_1910555_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1910551_1911115_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|1911237_1911639_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1912210_1913038_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001790712.1\|1913040_1913160_-	hypothetical protein	NA	NA	NA	NA
WP_001196362.1\|1913271_1914273_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	2.6e-184	99.4
WP_001008549.1\|1914394_1914859_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.5e-70	100.0
WP_001159037.1\|1914871_1916053_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	5.6e-226	99.5
WP_000493887.1\|1916063_1916696_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	5.5e-111	98.6
WP_000384185.1\|1916702_1917734_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.0e-196	98.8
WP_001261668.1\|1918226_1919729_-	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	1.9e-29	98.6
WP_000221177.1\|1920251_1920566_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	9.8e-53	98.1
WP_000989121.1\|1920565_1921858_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_001032833.1\|1921944_1922799_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1923074_1923299_-	hypothetical protein	NA	NA	NA	NA
WP_000671057.1\|1923497_1923968_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	8.8e-82	98.1
WP_001153742.1\|1924080_1924524_+	competence protein ComK	NA	NA	NA	NA
WP_001030469.1\|1924510_1924954_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
WP_001168903.1\|1925249_1925885_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1926324_1927038_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091442.1\|1927297_1927600_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1927855_1928221_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623470.1\|1928217_1928571_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	3.8e-21	94.0
WP_000453306.1\|1930567_1931401_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	7.8e-158	99.3
WP_000366163.1\|1931612_1932521_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933820.1\|1932642_1933839_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.3e-218	99.5
WP_000109906.1\|1934210_1935803_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_001822900.1\|1936180_1936927_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.4e-142	98.8
WP_000672013.1\|1936931_1937405_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
WP_000718107.1\|1937470_1937728_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778528.1\|1937724_1938726_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.3e-185	97.3
WP_088401725.1\|1938730_1940209_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.1e-282	97.4
WP_012840523.1\|1940367_1940823_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.6e-80	99.3
WP_001795210.1\|1941125_1941776_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	2.9e-51	94.0
WP_000070642.1\|1941856_1942852_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.6e-67	97.9
WP_000669024.1\|1942926_1943553_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	3.1e-74	79.8
WP_000627540.1\|1943593_1943935_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	1.1e-54	94.7
WP_000414216.1\|1944035_1944608_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	2.3e-23	93.1
WP_001801861.1\|1945962_1946058_+	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_001792025.1\|1946180_1946282_+	hypothetical protein	NA	NA	NA	NA
WP_000072627.1\|1947357_1948587_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	4.0e-134	64.7
WP_001793440.1\|1948579_1950319_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.4e-289	100.0
WP_001791797.1\|1950299_1950434_-	hypothetical protein	NA	NA	NA	NA
WP_001038752.1\|1950496_1951216_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.9e-131	99.6
WP_011447030.1\|1951317_1951425_+	hypothetical protein	NA	NA	NA	NA
WP_001038704.1\|1951373_1952093_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	4.6e-130	99.6
WP_001038872.1\|1952213_1952933_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.3e-129	98.7
WP_001039454.1\|1952990_1953713_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	3.5e-130	98.3
WP_001039427.1\|1953837_1954545_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	7.9e-127	97.0
WP_001092780.1\|1955508_1956090_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	9.6e-54	64.8
WP_000469591.1\|1956562_1956781_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	2.0e-25	80.6
WP_000550252.1\|1957036_1957510_+	hypothetical protein	NA	NA	NA	NA
WP_000543854.1\|1957514_1958306_+	DUF1828 domain-containing protein	NA	NA	NA	NA
WP_000782463.1\|1958675_1959659_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	1.8e-185	99.4
WP_000473596.1\|1959660_1960596_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP017090

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection