CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022207	Francisella noatunensis subsp. noatunensis FSC772 chromosome, complete genome	2 crisprs	cas3,csa3,cas2,cas1,cas4,DEDDh	0	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022207_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022207_1

1048446-1048808

Unclear

V-A

Consensus_repeat	Method
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CRISPRCasFinder
ATCTACAACAGTAGAAATTNTTTAAAGTTCTTAGAC	CRT
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	PILER-CR

5 spacers

cas2,cas1,cas4

The CRISPR arrays of NZ_CP022207_1

>merge|NZ_CP022207|1|1048446-1048808|CRISPRCasFinder,CRT,PILER-CR
ATCTACAGTAACAGAATTTTTTTAATGTTTTTAGACCTCTAAATGTTCGTATATATAGTATCAAGTATCTACAACAGTAGAAATTGTTTAAAGTTCTTAGACTCGCTTGGGAAAGCCATTACCAAAAACAAAATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACACCGCCTACACTTAATCAGTGTGATAAAATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACGTTGTTAACGAGCATAAAAAGAGATTTTGGATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACACAAGAAATTGACAAGATCAGATCGACTGATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

>NZ_CP022207|1|1|1048446-1048808|CRISPRCasFinder
ATCTACAGTAACAGAATTTTTTTAATGTTTTTAGAC	CTCTAAATGTTCGTATATATAGTATCAAGT
ATCTACAACAGTAGAAATTGTTTAAAGTTCTTAGAC	TCGCTTGGGAAAGCCATTACCAAAAACAAA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ACCGCCTACACTTAATCAGTGTGATAAA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	GTTGTTAACGAGCATAAAAAGAGATTTTGG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ACAAGAAATTGACAAGATCAGATCGACTG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

>NZ_CP022207|1|1|1048446-1048808|CRT
ATCTACAGTAACAGAATTTTTTTAATGTTTTTAGAC	CTCTAAATGTTCGTATATATAGTATCAAGT
ATCTACAACAGTAGAAATTGTTTAAAGTTCTTAGAC	TCGCTTGGGAAAGCCATTACCAAAAACAAA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ACCGCCTACACTTAATCAGTGTGATAAA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	GTTGTTAACGAGCATAAAAAGAGATTTTGG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ACAAGAAATTGACAAGATCAGATCGACTG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

>NZ_CP022207|1|1|1048512-1048808|PILER-CR
ATCTACAACAGTAGAAATTGTTTAAAGTTCTTAGAC	TCGCTTGGGAAAGCCATTACCAAAAACAAA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ACCGCCTACACTTAATCAGTGTGATAAA
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	GTTGTTAACGAGCATAAAAAGAGATTTTGG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ACAAGAAATTGACAAGATCAGATCGACTG
ATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022207.1\|WP_088821276.1\|1043213_1043567_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022207.1\|WP_088821285.1\|1056174_1057245_-\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435
NZ_CP022207.1\|WP_088821273.1\|1039870_1040350_+\|tryptophan-rich-sensory-protein	unknown	unknown	gnl\|CDD\|320706
NZ_CP022207.1\|WP_088821279.1\|1046971_1047547_+\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP022207.1\|WP_088821278.1\|1045501_1046560_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275338
NZ_CP022207.1\|WP_088821275.1\|1042426_1043185_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349968
NZ_CP022207.1\|WP_088821281.1\|1049200_1050205_-\|type-V-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|213942
NZ_CP022207.1\|WP_088821284.1\|1055511_1056159_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|309968
NZ_CP022207.1\|WP_004287654.1\|1058962_1059304_-\|chorismate-mutase	unknown	unknown	gnl\|CDD\|214841
NZ_CP022207.1\|WP_088821274.1\|1040342_1042289_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP022207.1\|WP_088821871.1\|1050208_1050745_-\|type-V-CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|213941
NZ_CP022207.1\|WP_004287666.1\|1043581_1044031_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP022207.1\|WP_088821282.1\|1053618_1055082_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|182554
NZ_CP022207.1\|WP_088821280.1\|1047556_1048357_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|177659
NZ_CP022207.1\|WP_088821277.1\|1044357_1045473_+\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|225591
NZ_CP022207.1\|WP_066047317.1\|1048947_1049220_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP022207.1\|WP_042518253.1\|1044027_1044279_-\|glutaredoxin	unknown	unknown	gnl\|CDD\|239510
NZ_CP022207.1\|WP_004287655.1\|1058456_1058927_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|238207
NZ_CP022207.1\|WP_004287656.1\|1057241_1058408_-\|DUF819-family-protein	unknown	unknown	gnl\|CDD\|227792
NZ_CP022207.1\|WP_088821283.1\|1055301_1055493_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP022207.1\|WP_088821285.1\|1056174_1057245_-\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	2.44248e-94
NZ_CP022207.1\|WP_088821273.1\|1039870_1040350_+\|tryptophan-rich-sensory-protein	gnl\|CDD\|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	4.57235e-42
NZ_CP022207.1\|WP_088821279.1\|1046971_1047547_+\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	3.23351e-16
NZ_CP022207.1\|WP_088821278.1\|1045501_1046560_-\|radical-SAM-protein	gnl\|CDD\|275338	TIGR04545, rSAM_ahbD_hemeb, heme b synthase. Members of this family are AhbD (alternative heme biosynthetic protein D), a radical SAM enzyme in sulfate-reducing bacteria and methanogens that performs the last decarboxylations to synthesize heme b from Fe-coproporphyrin III. Members include DVU_0855, previously included in error in TIGR04055, the NirJ2 family thought to be involved in heme d1 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	6.30368e-142
NZ_CP022207.1\|WP_088821275.1\|1042426_1043185_+\|RNA-methyltransferase	gnl\|CDD\|349968	cd18095, SpoU-like_rRNA-MTase, SAM-dependent rRNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	4.35025e-50
NZ_CP022207.1\|WP_088821281.1\|1049200_1050205_-\|type-V-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|213942	TIGR04329, hypothetical_protein_SbacW_07302_partial, CRISPR-associated endonuclease Cas1, subtype PREFRAN. Members of this family are the Cas1 endonuclease of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	0
NZ_CP022207.1\|WP_088821284.1\|1055511_1056159_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|309968	pfam05057, DUF676, Putative serine esterase (DUF676). This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.	2.23767e-10
NZ_CP022207.1\|WP_004287654.1\|1058962_1059304_-\|chorismate-mutase	gnl\|CDD\|214841	smart00830, CM_2, Chorismate mutase type II. Chorismate mutase, catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine..	2.35381e-05
NZ_CP022207.1\|WP_088821274.1\|1040342_1042289_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP022207.1\|WP_088821871.1\|1050208_1050745_-\|type-V-CRISPR-associated-protein-Cas4	gnl\|CDD\|213941	TIGR04328, hypothetical_protein_HMPREF9709_01098, CRISPR-associated protein Cas4, subtype PREFRAN. Members of this family are the Cas4 protein of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	3.3495e-102
NZ_CP022207.1\|WP_004287666.1\|1043581_1044031_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	3.57157e-25
NZ_CP022207.1\|WP_088821282.1\|1053618_1055082_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|182554	PRK10565, PRK10565, putative carbohydrate kinase; Provisional.	4.2992e-79
NZ_CP022207.1\|WP_088821280.1\|1047556_1048357_+\|alpha/beta-hydrolase	gnl\|CDD\|177659	PLN00021, PLN00021, chlorophyllase.	4.51738e-07
NZ_CP022207.1\|WP_088821277.1\|1044357_1045473_+\|linear-amide-C-N-hydrolase	gnl\|CDD\|225591	COG3049, COG3049, Penicillin V acylase and related amidases [Cell envelope biogenesis, outer membrane].	6.13922e-44
NZ_CP022207.1\|WP_066047317.1\|1048947_1049220_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	4.05897e-13
NZ_CP022207.1\|WP_042518253.1\|1044027_1044279_-\|glutaredoxin	gnl\|CDD\|239510	cd03418, GRX_GRXb_1_3_like, Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. The flow of reducing equivalents in the GRX system goes from NADPH -> GSH reductase -> GSH -> GRX -> protein substrates. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including E. coli GRX1 and GRX3, which are members of this subfamily.	2.7418e-12
NZ_CP022207.1\|WP_004287655.1\|1058456_1058927_-\|glutathione-peroxidase	gnl\|CDD\|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	2.74178e-83
NZ_CP022207.1\|WP_004287656.1\|1057241_1058408_-\|DUF819-family-protein	gnl\|CDD\|227792	COG5505, COG5505, Predicted integral membrane protein [Function unknown].	2.65449e-66

>NZ_CP022207.1|WP_088821280.1|1047556_1048357_+|alpha/beta-hydrolase
MLKAKFFLSFVLFSIFATVFTFSMSNAQDSKNSSKIIKETANISLNIASSNYDVFYQKSNQNLPVVIVVHGFSRSKDNMSGWGSFLASHGYFVVVPNLPFWANHSKNAKFISKLINYIYSNTDYTSIINNDLALVGFSAGGLATLIATSESTKVKHWIGLDPVDVGNLGSQAAKNINCPTYIIAAPASGCNANNNYKYFITSLKDNTLIKVSGAVHVDAEWPTTRFAEFFCGKSTPQKRERFHDDVLRILDRNFKNESHIKNIKRY
>NZ_CP022207.1|WP_088821279.1|1046971_1047547_+|outer-membrane-lipoprotein-carrier-protein-LolA
MLKKVAIATSILVSGLVYAAPSADFAKVEEQLVKNDNYSGHFIQSRKIQGLDKPILASGEFELSKKDGLEWNQEKPFKSSLKATKDTITIKTADSPKSVFGEEDSPMVFSFTKIFLSVLEGDSKVIYDNFNTKFSGTTDNWTLVLTPKTELLSKALKEVTLKGAETITYVEVVDAQNNVMDIQFSDIEIDS
>NZ_CP022207.1|WP_088821278.1|1045501_1046560_-|radical-SAM-protein
MKHQLKWMAWETTRRCNLKCVHCRSSSECEVVGHPDFSTEEGFRIIDNIVEFANPVLVLSGGEPFLRADIFELAEYGASKGLRMALATNGSLVTDEICKRIKNSSISIVSLSIDGATAETHDDFRSQKGAFEATVRAAKLFKKHDIPFLINSSFTKRNQHEIKDVYKLAKSLEATAWYLFMIVPTGRGEELMQELIDVNDYQDILNWHYDMEADEQDMLVRPTCAPHYYRIRFERNKEDNAKVRSRALSFGTGGGKGCIAGQSICLLDVDGNVYPCSYLPVSAGNVKEKSFADIWQNSDVMHDMRDFSAYEGKCGSCEFIKICGGCRARAYNIHGSYLAEEPFCNHMPIRMK
>NZ_CP022207.1|WP_088821277.1|1044357_1045473_+|linear-amide-C-N-hydrolase
MCTNVFINKNQYKIEARSMDFPINIAFKNGWGYVGIENVTDVVIDADKIPESRIAKWTSKYGYFCRLGFESYVTDGLNTQGFSYSILYLDGTVYPSYDDNDNRPALAVYELGNFLLAMAKDVADALELISEYQIVNSAVKLKDGIYIKNIPLHMCLRDANGNSAMIEFIGGKMYIHKNAGNVLTNAPTYEWHLSNIEEYKSLLQPSVNNSNPKFSDRVINYADTISSSRPEVAQLVGLPRDFSAAARFVRSYILSELMLEPKSNREAIFHAASIIANASVPPYEKSMTLWTTIKDLKNLTVAYKDNAVYQGTGPVGVYAMNIDNGYVTYDLNAMNFYDIPPAEQDSGLKVTSPNEIKQIIDMSAVVGLERQ
>NZ_CP022207.1|WP_042518253.1|1044027_1044279_-|glutaredoxin
MTQQFNKIVLYRMVTPEKTCPYGLKAKALFEEKGWCFEDHILKTRAETDAFKHKYNLETTPLIFIDDKQIGGYSDLLEFLGQK
>NZ_CP022207.1|WP_004287666.1|1043581_1044031_-|acyl-CoA-thioesterase
MNQQLKYFVLSTKVLPEHIDPNNHLNNIVYLQWMQDVAIEHVKANKVFDLTESQGLTWFAKKHTIEYLSQGFLGDDIAVVTWVESITKISTFRKYHIYRKSDKALLCKADTLWVMINAQKGRPAKIPTELVEIFDKYNDFEIDNIESLI
>NZ_CP022207.1|WP_088821276.1|1043213_1043567_+|hypothetical-protein
MSKCKTHQNHEHKHQDNCGHTRIKHGDHYDYLHDGHLHHEHNGHYDEHTLDVTTKNPDECKPIKDECCDHVHGPDCGHEAVPHGDHIDYIVDGRLHHRHGNHCDDHGPVEVIKNNKK
>NZ_CP022207.1|WP_088821275.1|1042426_1043185_+|RNA-methyltransferase
MKNLSQKLIKEIKKLHSPQGRKKSIYYVIEGLRCCDEALSRLPKEDLIALLTTENTDSISYPVDKKYILSEKDLNELTQTQNSQGVLILAKKKDTSSDFEFKDDFILVLDRIQDPGNIGTILRTAIAVGLTEIVLIDGTVDPFNPKAIRAGMGAQFSLKFRYFENLSAVRNHPTLKERKIWLTTPHEGVSCYSEEFKLSNSVLVFGEEANGIEDFSVGEKTMIPTLSNIESLNVAQAATIYLFEGLRQKMLK
>NZ_CP022207.1|WP_088821274.1|1040342_1042289_-|BCCT-family-transporter
MQREKGAYAPVFYPAIILAIVLSLSGIFYPNQFASHIQNLQNLILEKFGWAYILAMSVFLCLCLILMFSRFGDIKLGQEHDLPEYSNISWFAMLFAAGMGIGLMFYGVAEPLKHFLAPPNMSSDELVLVKEAMNTTFFHWGIEAWSVYAIVGLSLAYFAYRHDLPLLPRSVLYPILGRHIYGLLGHAIDVFAVLGTLFGVATSLGFGAMQVSAGMSFLTGLPDTVNMQVIYIVVIVALATISVGLGLEKGIKALSNFNIILAVLLLVFILLLGNSSVLVRDYIQNIGYYLSTIVNQTFNLYAYNQENQEWLKSWTLFYWGWWIAWSPFVGMFIAKVSRGRTIRQFTIGVLFIPVGFTFLWMTVFGNSAIEIAMNGNGEALIDAANNNIPVALFEFLQHFPFSTLLSVLAVFLIVTFFVTSADSGALVIDILATGNAKQSITLQRIAWSVLSGLLAISLILAGGLQALQSATIISAFPLLFILFLMCVSLIKSLRLDYLRLKSIETHSTIVQFAKANTSWQKRLEAIAHKPSKDQAIEFLQKDVTTAIIEVATEMEKNGINTEVIKDHDHIQLAISIEGNEDFIYSVMLRSYQSKFGNYNRVEVLLSHGGQYYDIMGYSKDQVIADIVNQYDKHLHYLHLVVADKDIVN
>NZ_CP022207.1|WP_088821273.1|1039870_1040350_+|tryptophan-rich-sensory-protein
MNCNIKNKDYISLAAFIIVILGIGMSVGALTATSIPTWFAKLKYPFFAPPNWIFAPVWTVLYIMIAISGWLVFKQKALREKVFIIYAIQLGLNFLWSFIFFCWHNIDLALLEISILWIFIAWNLKIFMDINKVAGYLLIPYLLWVGFAWILNLNYAMLN
>NZ_CP022207.1|WP_066047317.1|1048947_1049220_-|CRISPR-associated-endonuclease-Cas2
MLIVSYDFSNNKVRAKFAKFLEGYGVRLQYSVFELKYSKRMLDLILAEIENNYVPLFTNADSVLIFNAPDKDVIKYGYAIHREQEVVFID
>NZ_CP022207.1|WP_088821281.1|1049200_1050205_-|type-V-CRISPR-associated-endonuclease-Cas1
MFSRNDIESKNIVFVNIFDGVKLSLSLGNIVIKDKETDEVKTKLSVHKVLALFIVGNMTMTSQLLETCKKNAIQLVFMKSSFRPYLCFGDITEANFLARYKQYSVVEQDITLARIFITSKIRNQHNLVKSLRDKTPEQQEVVKKNKQLIAELENTTSLAELMGIEGNVAKNFFKGFYGHLDNWQGRKPRIKQDPYNVVLDLGYSMLFNFVECFLRLFGFDLYKGFCHQTWYKRKSLVCDFVEPFRCIVDNQVRKSWNLRQFCIEDFGCKNEQFYIKKDKTKDYSKILFAEIISYKLEIFEYVREFYRAFMRDKEIAEYPIFCYETRRVYVNSQL
>NZ_CP022207.1|WP_088821871.1|1050208_1050745_-|type-V-CRISPR-associated-protein-Cas4
MTWLNDFIFCPYSIYLHNIYSNASDTTYYSSSQTKGRDAHKSIDKGIYSTKKDDLIGIDVINHKYGLVGKIDIFHKDKGLLVERKRQIKTIYDGYKYQLYAQYFCLQEMGYDVKAIKFYSMVDNKSYPIEIPTSAELEKFEKHIQTIKQYNPMDNSFRQNIEKCKFCIYANLCDKTDL
>NZ_CP022207.1|WP_088821282.1|1053618_1055082_-|NAD(P)H-hydrate-dehydratase
MQFLTEKQNREIEEYAISQGLNLIENASDEIVKLICNKFDKQSKVLVIAGSGNNGSDGIAAAIKLFSLGYDVDVYRVFPKGNQDNQNYYQEFLKLKTPLDKLPDINNYDVVIDGIFGIGLDRDLQGDILEFVKVINQNSKYTLAIDVPSGLGAFNAKVYGEAIQANETITFLADKQGLHTGDGLDYAGQVTVKELIDNQNIKITQLEYQVSKNHIQDINLDNILRKKKNTNKGTYGDLAIIGGNIGMNGALQLAGRSSLYSGCGKVSMISLDKDFRADMSIPELMIKSLEDIPKNLNTFSALVVGVGFDTTDDSQQVLQLIIDNLTQPAIFDADALNIISTNQQIREKFIQLENKIITPHPAEAARLLGCTTKEVQDDRFVAVRALAKKYNSTVVLKGAGSLICKSDEIYINATGNQGMAVAGQGDVLSGIIGAFLVQGLDTLSASRLAVYVHGLAGDNLAKKLGGYVGIFPSRVAEEVCEILNFLN
>NZ_CP022207.1|WP_088821283.1|1055301_1055493_+|hypothetical-protein
MKKIAILIISLILFNLGFSIHTNDNKLFEATQFNNKNCRYAHEVGHNSFSEPEMNLACKPRSE
>NZ_CP022207.1|WP_088821284.1|1055511_1056159_-|alpha/beta-fold-hydrolase
MSKDKVVILVHGFIKNSKDMSSLANFLKDSYDEVIAVDLPTTFVSVDVAVNKLCQIVKSIPSSKSLIFVAHSMGGIISCMTIDKLQLTNIEKCVFIASPFAGSRVADFGDRIPFYSRVLKPNKDLKVTDKYLEICNRVAEKVSVGLLDGNKYSKLNFLARLCLRNEHDGLVEVSSVFSINSLDRITLNKNHSQIHHDEETLTKVSFFLKTGRFLS
>NZ_CP022207.1|WP_088821285.1|1056174_1057245_-|dipeptide-epimerase
MSKIIDIKTSIIKIPLKRTFITAVRSTNHIDSLAVELTLDNRVKGYGVAPATTAITGDTLQGMQYIIREIFAPVILGSDLSDYKQTLELAFKKVMFNSAAKMAIDLAYHDLLAKEQNMSVAKLLGAKANSIVTDVSISCGSVAETIQNIQNGVEANFTAIKVKTGADFNRDIQLLKALDNEFSKNIKFRFDANQGWNLAQTKQFIEEINKYSLNVEIIEQPVKYYDIKAMAEITKFSNILIVADESVFDAKDAERVIDEQACNMINIKLAKTGGILEAQKIKKLADSAGISCMVGCMMESPAGILATASFALAEDITVADLDPLDWVAKDLYSDYITFNEPNIILKDNLNGFGFNL
>NZ_CP022207.1|WP_004287656.1|1057241_1058408_-|DUF819-family-protein
MISTSLSYISSLLLICSLIVLLSSKSKSKLFEYFPAIVIIYFVIVVLSAMGFWDSKSSEIIQTRLQLQDLILPVMLFLMLIRCDIRVVIKLGRKLLIAFFGATVSIIIAFVIMYLTVGKYISPDAWKGFSALSASWMGGTGNMIAVKQALSTPDNQMGYILLTDSISYSIWFAFLFALISRANIFDKWTKAGCIEEHISKVDINNPYDVKGDINFVGIFVLIAMAFTATDIAKILSSYLPATDLISAKTWTILLVTLFGFVGAMTPLAKIRSDSIIASIFLYFLVALIASGSSFKGFSQAPIYIVCGLMVLVIHAILMVIIAKIFRLNLAMCSIASLANIGGIAGAPILASAYTRSLVSIAVVMALLGFLIGTQGGLIVAKILSGFAI
>NZ_CP022207.1|WP_004287655.1|1058456_1058927_-|glutathione-peroxidase
MSIYDFKLTKNDGSEYSLPNNKVLLIVNVASKCGFTKQYKGLQHLHKLYPDLEIVAFPCNSFGGQEPGSDEEIKSFCETNYDVTFPIMKKTKVNGKDAEPLFEYLKERAKGVLGTEAIKWNFTKFLVSKDGETVIRYAPKTIPEDLISDIENFLKD
>NZ_CP022207.1|WP_004287654.1|1058962_1059304_-|chorismate-mutase
MKKYILILLSVATFSLSFAMSPSSFIAKPTSEKYESEIMDADEQIIKFIAKRQELRNQMLDLQKNQKLPSNDPFEDKDLAATRTNFAIQYNVSPKLVDQVFDILNSSAQKPAK

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Crispr_ID: NZ_CP022207_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022207_2

1895652-1895761

Orphan

Consensus_repeat	Method
TGTTGGAAATAAAAATAAAGATGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022207_2

>merge|NZ_CP022207|2|1895652-1895761|CRISPRCasFinder
TGTTGGAAATAAAAATAAAGATGTTCATATAAGTAACGTTAGAGGTGGTAATGAGTAATATAACATCTGGTAACACAATTATTAGTGTTGGAGATAAAAATAAAGATGTT

>NZ_CP022207|2|2|1895652-1895761|CRISPRCasFinder
TGTTGGAAATAAAAATAAAGATGTT	CATATAAGTAACGTTAGAGGTGGTAATGAGTAATATAACATCTGGTAACACAATTATTAG
TGTTGGAGATAAAAATAAAGATGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022207.1\|WP_088821774.1\|1897856_1898354_+\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|181857
NZ_CP022207.1\|WP_004286878.1\|1888433_1889153_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|235454
NZ_CP022207.1\|WP_088821777.1\|1902435_1903461_+\|hydrogenase-expression/formation-protein-HypE	unknown	unknown	gnl\|CDD\|100033
NZ_CP022207.1\|WP_088821775.1\|1898377_1898734_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022207.1\|WP_088821904.1\|1890458_1891355_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|226985
NZ_CP022207.1\|WP_088821768.1\|1891336_1891930_+\|cytochrome-b	unknown	unknown	gnl\|CDD\|225580
NZ_CP022207.1\|WP_088821770.1\|1892974_1894237_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP022207.1\|WP_088821780.1\|1905428_1906235_+\|sulfhydrogenase-subunit-delta	unknown	unknown	gnl\|CDD\|224852
NZ_CP022207.1\|WP_088821778.1\|1903471_1904572_+\|sulfite-reductase-subunit-A	unknown	unknown	gnl\|CDD\|379938
NZ_CP022207.1\|WP_088821771.1\|1894722_1895436_+\|hydrogenase-nickel-incorporation-protein-HypB	unknown	unknown	gnl\|CDD\|349775
NZ_CP022207.1\|WP_088821779.1\|1904574_1905426_+\|Ni/Fe-hydrogenase-subunit-gamma	unknown	unknown	gnl\|CDD\|99817
NZ_CP022207.1\|WP_088821776.1\|1901342_1902434_+\|hydrogenase-formation-protein-HypD	unknown	unknown	gnl\|CDD\|237892
NZ_CP022207.1\|WP_088821769.1\|1892012_1892795_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_CP022207.1\|WP_088821766.1\|1886915_1887668_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP022207.1\|WP_088821906.1\|1898856_1901112_+\|carbamoyltransferase-HypF	unknown	unknown	gnl\|CDD\|223146
NZ_CP022207.1\|WP_042517076.1\|1894373_1894712_+\|hydrogenase-maturation-nickel-metallochaperone-HypA	unknown	unknown	gnl\|CDD\|376468
NZ_CP022207.1\|WP_088821767.1\|1887684_1888425_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP022207.1\|WP_004286877.1\|1889216_1890365_-\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|184856
NZ_CP022207.1\|WP_042524196.1\|1901113_1901329_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|376549
NZ_CP022207.1\|WP_088821781.1\|1906237_1907533_+\|Ni/Fe-hydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225798

Protein	Function_ID	Function_description	E-value
NZ_CP022207.1\|WP_088821774.1\|1897856_1898354_+\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|181857	PRK09437, bcp, thioredoxin-dependent thiol peroxidase; Reviewed.	8.37947e-95
NZ_CP022207.1\|WP_004286878.1\|1888433_1889153_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|235454	PRK05421, PRK05421, endonuclease/exonuclease/phosphatase family protein.	1.59142e-84
NZ_CP022207.1\|WP_088821777.1\|1902435_1903461_+\|hydrogenase-expression/formation-protein-HypE	gnl\|CDD\|100033	cd02197, HypE, HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the ATP-binding domains of the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP.	1.84514e-166
NZ_CP022207.1\|WP_088821904.1\|1890458_1891355_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|226985	COG4638, HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only].	4.27675e-31
NZ_CP022207.1\|WP_088821768.1\|1891336_1891930_+\|cytochrome-b	gnl\|CDD\|225580	COG3038, CybB, Cytochrome B561 [Energy production and conversion].	1.69779e-32
NZ_CP022207.1\|WP_088821770.1\|1892974_1894237_+\|MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.3527e-91
NZ_CP022207.1\|WP_088821780.1\|1905428_1906235_+\|sulfhydrogenase-subunit-delta	gnl\|CDD\|224852	COG1941, FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion].	1.39983e-50
NZ_CP022207.1\|WP_088821778.1\|1903471_1904572_+\|sulfite-reductase-subunit-A	gnl\|CDD\|379938	pfam17179, Fer4_22, 4Fe-4S dicluster domain.	2.77233e-47
NZ_CP022207.1\|WP_088821771.1\|1894722_1895436_+\|hydrogenase-nickel-incorporation-protein-HypB	gnl\|CDD\|349775	cd05390, HypB, nickel incorporation protein HypB. HypB is one of numerous accessory proteins required for the maturation of nickel-dependent hydrogenases, like carbon monoxide dehydrogenase or urease. HypB is a GTP-binding protein and has GTP hyrolase activity. It forms homodimer and is capable of binding two nickel ions and two zinc ions. The active site is located on the dimer interface. Energy from hydrolysis of GTP is used to insert nickels into hydrogenases.	8.4929e-109
NZ_CP022207.1\|WP_088821779.1\|1904574_1905426_+\|Ni/Fe-hydrogenase-subunit-gamma	gnl\|CDD\|99817	cd06221, sulfite_reductase_like, Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is linked to ferredoxin and reduces NH2OH and SeO3 at a lesser rate than it's normal substate SO3(2-). Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+.	1.22061e-122
NZ_CP022207.1\|WP_088821776.1\|1901342_1902434_+\|hydrogenase-formation-protein-HypD	gnl\|CDD\|237892	PRK15062, PRK15062, hydrogenase isoenzymes formation protein HypD; Provisional.	0
NZ_CP022207.1\|WP_088821769.1\|1892012_1892795_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	5.07477e-46
NZ_CP022207.1\|WP_088821766.1\|1886915_1887668_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	3.85968e-43
NZ_CP022207.1\|WP_088821906.1\|1898856_1901112_+\|carbamoyltransferase-HypF	gnl\|CDD\|223146	COG0068, HypF, Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP022207.1\|WP_042517076.1\|1894373_1894712_+\|hydrogenase-maturation-nickel-metallochaperone-HypA	gnl\|CDD\|376468	pfam01155, HypA, Hydrogenase/urease nickel incorporation, metallochaperone, hypA. HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.	4.61425e-40
NZ_CP022207.1\|WP_088821767.1\|1887684_1888425_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.27945e-40
NZ_CP022207.1\|WP_004286877.1\|1889216_1890365_-\|Na+/H+-antiporter-NhaA	gnl\|CDD\|184856	PRK14854, nhaA, pH-dependent sodium/proton antiporter; Provisional.	0
NZ_CP022207.1\|WP_042524196.1\|1901113_1901329_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|376549	pfam01455, HupF_HypC, HupF/HypC family.	9.93004e-28
NZ_CP022207.1\|WP_088821781.1\|1906237_1907533_+\|Ni/Fe-hydrogenase-subunit-alpha	gnl\|CDD\|225798	COG3259, FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion].	4.79211e-69

>NZ_CP022207.1|WP_088821771.1|1894722_1895436_+|hydrogenase-nickel-incorporation-protein-HypB
MCTTCGCGTDSNHHHHHHGHEGDAVKLEKAILEANDQYAEQNRDVLAKDNNIALNFVSSPGSGKTSLLERTIKELGGSHPIVVVEGDQHTDLDAERIRKAGAKAYQINTGKACHLDAHMVGHAFEHLGEIKDGFVMIENVGNLICPAMFDLGEKHRVAVISTTEGADKPLKYPDMFYYADVVVINKIDLSPYIDFDIQECIANIKKIRSDVKIFELSVKTGAGFDSWLDWLRSLKIT
>NZ_CP022207.1|WP_042517076.1|1894373_1894712_+|hydrogenase-maturation-nickel-metallochaperone-HypA
MHEFSLCQSVINIAKKAAENNSKKVSKVVVKIGNLAGVDVESFEFWFPVAAKDSVLEQAKLEIVHEQAIAKCKACEHEFELTRLYEQCPNCGSFEKDILKGKDMLVESIVFN
>NZ_CP022207.1|WP_088821770.1|1892974_1894237_+|MFS-transporter
MLQKNQRKALLLSSLGGMLEFYDFIIYALLASYISKLFFPIQSAITSLLIAFSAYAVGYLARPFGGIIFGHFGDKYGRKKTFTISILIMALSTFLIGILPTYNSIGIMAPILLVLCRIAQGISVGGEIPGAITYVGEAVPEKRGFMTAVIFGFLILGVAIGFIVESLLLEFFTSQSMLTYGWRIPFILGGLFGLVAYYLRRQLIDIKEFNPFVNEEFSLPITKMLLTHRWNLIYSTIIVSFGALCFVTLFLLLPAYFSTILNLHLDNFTWINSLGVIIISILCVAVGLFADKVSRNLILLISILATCAFSFVIYTTYTSHQNFYFIAIVLSAILVALCWGNIPAMLIDLFKQDVRYTGIGFAYNLGFAVFGGLTPMIVISTIKFSNNNLAPAYILTAGAIITLIAMIINSLIQRRATEKV
>NZ_CP022207.1|WP_088821769.1|1892012_1892795_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MKKLTIAISSILLSTAVFAADAPTTTASSAKAESNGVDMSKVSYLIGRGVGEQLSKGKITIDQANFDKGLQSALAGQKSEIPEAKAQQIMQAFQKEMMEKMQKAQIEAATNNLKLANDFQQAIAKVDGIKEVDGSKGVYIQVLKQGDGAQPTKSDSVTVNYRGTTPTQAYADDKEAAIKTIQEGNLIGDQFDSSYDRGTPATFPLSGVVKCWQDAIPQMKVGEKAIVYCAPDTAYGSSGNAAIGPNQLLSFQVELLKVNS
>NZ_CP022207.1|WP_088821768.1|1891336_1891930_+|cytochrome-b
MAYSRLKYFSKVCKYYTIKKHSINLSMIMKYSLPVRVLHSLLAFLIIAQLILGFGYAYDLFDSRWIMTLHKSFGLVIFFVIPLLVVARFFSIKPPYNPPLPLLQLIIAKIVHLGLYISTFGMAFSGVVGSMLMGYPWKIFFVIPFPEIITPNFELGSKIFSYHYIFASVLLVLVVLHIAAALHHQLIVKDNILARMK
>NZ_CP022207.1|WP_088821904.1|1890458_1891355_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MNNIPKAWYAIAHIKEIKSKPIKLERLGKNLVLWKDAEKIIAMENRCPHRGVELSLGKVCDGAIACPFHGFRFDTQGNCIYTPETQGAIPKLQVKSYPTKIVADMIWINVFDEELDNSYAFEFAQNLYSDFAGKYSLLTDTWDNNIRHCIENQLDYTHLATVHKRSIGRGYKIPQDIKLNISNEYIEALKNQRLMLKYIFPNFWLLNNADKLKICVYFVPINEHQTKLYLVNYRKFLTGKIIKPIADIVFSITNKIILNEDKRVVKTQKYDEKYDTEDFLLRHDQIIKEFRKIWHTPD
>NZ_CP022207.1|WP_004286877.1|1889216_1890365_-|Na+/H+-antiporter-NhaA
MSANQNNQEIVGGLILFAAAFVAILINNSPLSIYYGMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREIISGALSKPSNIIIPAIAALAGLAVPSLIYLSINYDANITGWAIPSATDIAFTLGILALLGSRIPAKLKLLVVTIAIFDDIAAIVIIAIFYTKSLSLLSLSLGTLFILAMIICNRVFKVNRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFRENDKDSPANFMEESLHPWVIYFILPVFAFANAGINFSGMSISIIFEPITLGIILGLFVGKQLGIFSILAISKKLKLFKLGESFSSSQIYGISLLCGIGFTMSLFIGTLAFDDNYTLSAIKVGVIVGSLLSGICGYIVLRFIARNPH
>NZ_CP022207.1|WP_004286878.1|1888433_1889153_-|endonuclease/exonuclease/phosphatase-family-protein
MFERDSKKNQSTKFCLMSWNSYKIDYKDTETFKAYIRHTYFNHNIDIFCLQEAVHQHDTKFPIDKFDINFASNIVLRSHNYGVATVSHFPVIKNVKILTTHRESVINTHKASLITHLNIDGTKVVVVNIHAINFKSNKVYEYEFEKIKEYISPEKYKHPIIIAGDFNTWNRRRVKLIKDFCREFSFKVAFIDEPQLVKSFQSNHLDFVLYRGLNLEKASVLDCKKISDHNPIIAEFCIK
>NZ_CP022207.1|WP_088821767.1|1887684_1888425_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MKKIIHLLLLARMQVFKVYGYIVLLFSCLLMNTVGVLGASLKVRLFVCWIWSCLYRLGTLVILQIYVKVEGKENIPDYPCIYVSKHQSMLETFVFYGLVHDCCFVMKQELLEKPIFGKTNIFAEAIGVDRSKGLSAIKKVLEDGKDRIENKNLSIIIFPEGTRVPVGEHPKFHRSAMKLAKVSNVPIIPVAHNFGVYFGRKKGDFVKPGIARMSFGKPIDPKDYSVAELTDLCYDIINDKTKSYGG
>NZ_CP022207.1|WP_088821766.1|1886915_1887668_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MKSFFKKIWNILMWARMTAFQLYSFAVIGGCSVLINIFAFFNLPIAWRMAVCKVWTYLYWIGMLVFLQVYIRVSGRINIDKDYPCIYVSKHQSMLETFMFYGLIGKCHFIMKKELFDAPIFGTAMKNLGSIAIDRDKPRESLKKVVTDGKQSLADGINVVIFPEGTRVNIGEYPEFQRSAMKLAADANTYIIPVAHNFGRFFPKKWGQVIKPGIARMDFGKRIDPRDFDSKTLTTYCHKVITEKTKEFKG
>NZ_CP022207.1|WP_088821774.1|1897856_1898354_+|thioredoxin-dependent-thiol-peroxidase
MSKGEAMKTLKQGQLAPNFKLENQNNEEVSLSDFKGKKNVLIYFYPKAMTPGCTTQSIGLSTINDKLAKLDTVVLGISPDAPKRLKKFEERDSLTIQLLSDEDHKVAEQFGVWGEKKFMGKVYDGIHRISFFIDKDGKINHVFNKFKTKDHHEIVLEYIENYKNS
>NZ_CP022207.1|WP_088821775.1|1898377_1898734_+|hypothetical-protein
MNKIYKLLLNALNSWVSIIFIILYCIASFFYGQKLNDMSLFSASGSIMTIFGLFSMIKFTTIEKFINQEQIASSSTGITGPPISQEEATKLREENIKKARIRLKKNCEQKLKVFYSRY
>NZ_CP022207.1|WP_088821906.1|1898856_1901112_+|carbamoyltransferase-HypF
MQQTITKILVNGIVQGVGFRPFIYCLAKDLDLCGSVQNTPNGVEIILQCDESVSDSFITNMQAKLPPLANIETIEKTICQTENKFTEFKILNTLQGNSTTKIPADTTICDLCLDDIFNPQSRYYLYPYTSCTHCGPRFSTIQSLPYDRDKTTYKDFPLCDDCLASYTNPQDRHYHAQTVACSKCGPELSHSFAEISQAIKAGKIIAIKSQNGFKLVVDATNTKAVEELRKRKHRPNKPFALMALNTQSIQEHFAEVTTQQNELLSTTIRPIVLLKRHSTSTISSSIAPRINQLGFMLPTTGSDYILFYHLLNQPTGSSWLNEAHDLALIVTSANISGESIIANNNEALEKLKDIADLIVTDNRDIAIKSDDSVFHTVIDKNLPIRRSRGLVPQSIQLSEILPNILATGTFLKNTFCFIKDNQAFVSQHIGDMDSQANIEFFEQSLEHFQNMFGLKFDGIACDLHPDIYTTHFAQKFDLPIYQIQHHQAHLAAVIAEHNLQGHAIGLVLDGFGLGEDGIARGSELYHCDIDNLEFNRIGELDPIEYIGGDKVAKEPWRMALAVCHKYDLEIPNHLKEFPQAESLIKLLQNDSLPKGKTTSMGRLFDAVSGLLNICNINTYEAQAAIELESLADIPNIQYDTKSVSFKTNLNLKKLLKSIIKCDNISVASNLWHGTLAYALAQWISNSAQPRNIKNIILSGGCFQNKLLLTETYRQLKEMDFNIYISEKVPLNDGGVSLGQAWLGAKKYKKGE
>NZ_CP022207.1|WP_042524196.1|1901113_1901329_+|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCLAIPAEIVEIREDNQAIVNVGGVKKNISLALLRDEVLIGDFVIIHVGFALSKLDKEMAQQTLEDLKSII
>NZ_CP022207.1|WP_088821776.1|1901342_1902434_+|hydrogenase-formation-protein-HypD
MDYIQEFRAPKVAKSLLQQIAKEVDPNRQYNLMEFCGGHTHALHRYGIPSLLPENVKMIHGPGCPVCVLPIKRVDQAIFLASQKDVIFCSYADMIRVPGSHQDSLIKAKARGADVRMIYSVEDALKLAEENPNKKIIFFAIGFETTTPPTAVAIQLAIAKKLDNFLIFCNHVLTPVAMQAILSEDVKIDGFLGPSHVSVIIGSNAYDKVTKEYQKPMVVAGFEPLDVLQSILMVIKMINAGKIGVENQYTRAVVPNGNQLAQDLITQYLTIRDTFEWRGLGYIPNSALEIKDEYAKFDAEIYYQIPEVQGLEHKQCACPDILRGLKEPKDCKLFGVVCTPEQPMGACMVSSEGACAAHYQYGD
>NZ_CP022207.1|WP_088821777.1|1902435_1903461_+|hydrogenase-expression/formation-protein-HypE
MAVKLNIKNGVVDLAMGAGGKAMHHLIEQMIKKSFDSQYLAQAEDQAVLPQINGKFAMTTDSYVITPYFFRGGNIGSLAIHGTVNDLVVGGAKPLYISVGLILEEGLPLKDLKVILDSMAEAAKKANVKIVTGDTKVVEKGKGDGIFINTTGVGVIRDDFVTRDALEDGDEIIINGTLGDHGVAVMSQRAGLDFECQILSDATSLDNLVDSIYDNKCQIKTMRDPTRGGVGATLNEWANQYNVAIEIDEANLPVSREVQSACELLGLDPLYIANEGKILIACKPSQTQKVLDCLRGHPLGENAQVIATVRKSEQSQVFMKTTFGGKRRVDWLSGEQLPRIC
>NZ_CP022207.1|WP_088821778.1|1903471_1904572_+|sulfite-reductase-subunit-A
MSQFYFLKHDDLDRMISYFSGQGYEVMAPAVRDKSIVYDNINNASDLPWGYVDIQEPAKYEVIKTDAKKAFGWSVPVQSVKPMLFEEKETLWKVSRDENGRLAFNQSLNSKKYAVLGVRPCDLRAIEIQDRVFVENAYQDVRYKARREAMFIVAANCTTAHSNCFCIALGDKPEADKGFDIAMTEIDHGFVIETGSDKGRQTILALQLDPATGAQTYQAEQKVKAVYAMQEKTLPPIDQVEKALTSSYDHPQWDDVAARCLSCGSCTQSCPTCFCHTEKEEPSLDGKESEHTREWDSCFGLDHSYTHGELYREEPKHRYRQWLTHKFGTWREQFKTKGCVGCGRCITWCPVKIDVTEEINAICEEK
>NZ_CP022207.1|WP_088821779.1|1904574_1905426_+|Ni/Fe-hydrogenase-subunit-gamma
MIYPQDAYLPHEAEIVEFIQDADDIFTLRLRFVDEELRKNYKFHPGQFNMLYLYGVGEVAISIVNDRNFADDIFEHTIQVVGRITKGMDKLKTGETIGVRGPFGSSWPVEQAKGKDVVIMTGGLGNAPLVAATEEILKDRDAYGKVYVVQGIRDTSGLIYQDKYTRWNNQPNTEVLLAATAGEPHGPWKWYDGFVTAAIPDLDIDHKNTVVMTVGPEIMMKNVAKEFAKVGVPEEQIFVSLERSMKCAIGHCGHCQMGKEFVCKDGAVYAYPAVKKLLEIKGV
>NZ_CP022207.1|WP_088821780.1|1905428_1906235_+|sulfhydrogenase-subunit-delta
MSAQDKLKNLAPRPKIAVHKFSSCDGCQLALINDAVSLLTLAEMVDIVHFAEAGPLDEFADVDIAFIEGSVNTHHDIPRLQKIREKAKYVVAIGACAVAGGIQALRNYTNDAELLEWQKAVYPQDTDVIIKEDLSTAKAIKEYVNVDFEISGCPITTEQILKAIRQLLFGVEPEKVVDPVCTSCKHAGVTCVMVAKDEPCLGPVTADGCGAICPKLGRGCYGCFGASKYANLGAMTTRLKELGLSDKQIQDKYRFISSQDEVFKKAGV
>NZ_CP022207.1|WP_088821781.1|1906237_1907533_+|Ni/Fe-hydrogenase-subunit-alpha
MSRETVIEVPILARVEGEGALDLRIKDGKIDKCELRIYEPPRYFEKFLEGREPNAIIDAVARICGICPLAYQAGFSRAYESAFDITRTQWIDDMRLLMFLGEWIESHYLHVHLLAAPDFLGYRSAIEMAKDYPKEVVRGVKLQHLGNDILKLLGGRSVHPNGMKVSGFYKAPLVKEVHALIPKLKDALKEAKDVVEWVSTLSFPDTTIPFKMVSLSHPTEYPVFGDDVITSDGEKFHISEYDDHFREFHAPQSTALHSTTVDGQPILLGPLPRINLNFDKLPKHIQEMAHATGVKWPSKNMFHSVVARAIEGYWAIERALQVCENYSYTDTPCVDYTVKAADAWGAVEAPRGIQIDHIKVNDQGLAEKIRISAPTSQNLPCIEADLRIALENFGLDKPEDDIRLHAEMVIRNYDPCISCSAHFLTLNINRD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022207_1	1.2\|1048548\|30\|NZ_CP022207\|CRISPRCasFinder,CRT,PILER-CR	1048548-1048577	30	NZ_CP042327	Euhalothece natronophila Z-M001 plasmid pEu1, complete sequence	22997-23026	6	0.8
NZ_CP022207_1	1.2\|1048548\|30\|NZ_CP022207\|CRISPRCasFinder,CRT,PILER-CR	1048548-1048577	30	KY971610	Pseudomonas phage PspYZU05, complete genome	57129-57158	7	0.767

1. spacer 1.2|1048548|30|NZ_CP022207|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP042327 (Euhalothece natronophila Z-M001 plasmid pEu1, complete sequence) position: , mismatch: 6, identity: 0.8

tcgcttgggaaagccattaccaaaaacaaa	CRISPR spacer
tgtctggggagagccattaccaaaaatgaa	Protospacer
*  ** ****.***************..**

2. spacer 1.2|1048548|30|NZ_CP022207|CRISPRCasFinder,CRT,PILER-CR matches to KY971610 (Pseudomonas phage PspYZU05, complete genome) position: , mismatch: 7, identity: 0.767

tcgcttgggaaagccattaccaaaaacaaa	CRISPR spacer
cagatttttaaagccattatcaaaaacaaa	Protospacer
. * **   **********.**********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

81350 : 92249

Staphylococcus_phage(25.0%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004286749.1\|81350_83135_+	elongation factor 4	A0A2K9L6L3	Tupanvirus	4.2e-23	43.2
WP_042524302.1\|83248_84328_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_012280150.1\|84356_85301_-	hypothetical protein	NA	NA	NA	NA
WP_088820664.1\|85397_85916_-	peptide deformylase	A0A067XQZ3	Caulobacter_phage	2.6e-18	40.6
WP_042517268.1\|85919_86363_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.2e-25	43.6
WP_088820665.1\|86366_87578_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.2e-87	44.3
WP_088820666.1\|87570_88176_-	riboflavin synthase	A0A1V0SE20	Indivirus	1.5e-20	37.0
WP_088820667.1\|88168_89239_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	7.0e-50	37.7
WP_042517279.1\|89611_90880_+	sodium:proton antiporter	A0A2H4J178	uncultured_Caudovirales_phage	9.5e-30	35.1
WP_088820668.1\|90998_92249_+	sodium:proton antiporter	A0A2H4J178	uncultured_Caudovirales_phage	8.8e-28	33.1

DBSCAN-SWA_2

381052 : 390694

Enterococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012279910.1\|381052_381901_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	1.4e-32	40.7
WP_088820887.1\|382062_382353_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_088820888.1\|382600_383644_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	3.1e-55	36.3
WP_088820889.1\|383643_385953_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	6.8e-26	31.3
WP_088820890.1\|385955_386531_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	9.6e-22	36.4
WP_088820891.1\|386654_387146_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.0e-20	42.5
WP_088820892.1\|387147_388245_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_088820893.1\|388241_388595_-	YraN family protein	NA	NA	NA	NA
WP_088820894.1\|388687_390694_-	M3 family metallopeptidase	A0A1V0SID3	Klosneuvirus	1.5e-50	26.8

DBSCAN-SWA_3

1493618 : 1504054

Escherichia_phage(22.22%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088821562.1\|1493618_1494542_-	glycosyltransferase family 2 protein	V5USA4	Oenococcus_phage	1.7e-28	32.1
WP_088821563.1\|1494538_1495495_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_088821564.1\|1495542_1496856_-	nucleotide sugar dehydrogenase	A0A218MKK1	uncultured_virus	2.9e-21	26.1
WP_088821565.1\|1496906_1497908_-	dTDP-glucose 4,6-dehydratase	K7QJG5	Escherichia_phage	2.5e-81	47.9
WP_088821566.1\|1497917_1498787_-	dTDP-4-dehydrorhamnose reductase	A0A1D8EQE2	Escherichia_phage	4.6e-44	39.8
WP_088821567.1\|1498858_1499431_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.8e-36	52.0
WP_088821568.1\|1499427_1500318_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	5.0e-102	60.6
WP_088821569.1\|1500449_1501499_-	GDP-L-fucose synthase	D1LW79	Prochlorococcus_phage	3.4e-89	48.4
WP_088821570.1\|1501512_1502652_-	GDP-mannose 4,6-dehydratase	M1HAR7	Acanthocystis_turfacea_Chlorella_virus	9.5e-122	59.4
WP_088821571.1\|1502680_1504054_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	2.1e-54	31.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022207

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection