CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NZ_CP022183	Aeromonas salmonicida strain S68 plasmid pS68-2, complete sequence	0 crisprs	NA	1
NZ_CP022185	Aeromonas salmonicida strain S68 plasmid pS68-4, complete sequence	0 crisprs	NA	0
NZ_CP022184	Aeromonas salmonicida strain S68 plasmid pS68-3, complete sequence	0 crisprs	NA	0
NZ_CP022182	Aeromonas salmonicida strain S68 plasmid pS68-1, complete sequence	0 crisprs	NA	1
NZ_CP022186	Aeromonas salmonicida strain S68 chromosome, complete genome	9 crisprs	csa3,DEDDh,cas3,WYL,DinG	23

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

25702 : 64225

Shigella_phage(17.65%)

transposase,integrase

attL 19453:19469|attR 56963:56979

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
19453:19469	attL	NA	NA	NA	NA
WP_042468263.1\|25702_26695_+\|transposase	IS5 family transposase	Q38213	Escherichia_phage	1.5e-152	80.4
WP_157669342.1\|27487_27706_+	hypothetical protein	NA	NA	NA	NA
WP_042468261.1\|27796_28036_-	hypothetical protein	NA	NA	NA	NA
WP_042468260.1\|28050_28695_-	DNA methylase	A0A2K9VH43	Faecalibacterium_phage	1.3e-30	41.0
WP_052521838.1\|29086_31129_-	DUF3560 domain-containing protein	A0A0H3UZM4	Geobacillus_virus	2.4e-06	34.8
WP_042468258.1\|32479_32842_-	hypothetical protein	NA	NA	NA	NA
WP_080697405.1\|32881_33373_-	DNA repair protein RadC	A0A1B2LRS6	Wolbachia_phage	4.8e-14	33.6
WP_042468273.1\|34264_34663_+	S-adenosylhomocysteine hydrolase	NA	NA	NA	NA
WP_042468256.1\|34652_35618_+	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_042468255.1\|35663_36029_+	hypothetical protein	NA	NA	NA	NA
WP_042468254.1\|36047_36545_+	hypothetical protein	NA	NA	NA	NA
WP_042468253.1\|37052_37205_+	type I toxin-antitoxin system Hok family toxin	NA	NA	NA	NA
WP_157668949.1\|37657_38563_-	RNA-directed DNA polymerase	E5E3S8	Burkholderia_phage	2.6e-37	33.9
WP_042468251.1\|38594_38906_-	helix-turn-helix transcriptional regulator	E5E3S9	Burkholderia_phage	6.1e-15	47.8
WP_080697402.1\|40117_41182_-	ParA family protein	Q7M293	Enterobacteria_phage	9.4e-23	29.8
WP_155268747.1\|42323_42467_+	hypothetical protein	NA	NA	NA	NA
WP_042468250.1\|42536_42770_+	hypothetical protein	NA	NA	NA	NA
WP_042468249.1\|42925_46414_+	helicase SNF2	M4QQR7	Ostreococcus_lucimarinus_virus	7.3e-40	31.2
WP_076611341.1\|46514_47432_+\|transposase	IS5-like element ISAs4 family transposase	A0A1V0E8E1	Vibrio_phage	4.4e-93	55.8
WP_088822004.1\|47965_49654_-	AIPR family protein	E5G6M2	Salmonella_phage	1.0e-34	27.2
WP_042469092.1\|49700_50363_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_088814088.1\|50406_51093_-	resolvase	M9Q1K0	Clostridium_phage	3.1e-11	29.1
WP_157669184.1\|51554_52322_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	1.5e-75	57.3
WP_085941409.1\|52426_53588_+\|transposase	IS3-like element ISAs6 family transposase	Q716C2	Shigella_phage	2.8e-84	51.6
WP_080697429.1\|53641_53956_-\|transposase	IS3 family transposase	Q716C1	Shigella_phage	1.6e-18	45.4
WP_157668947.1\|54367_55243_-	hypothetical protein	NA	NA	NA	NA
WP_042468968.1\|56101_56527_+	hypothetical protein	NA	NA	NA	NA
WP_005320955.1\|56828_57077_+	hypothetical protein	NA	NA	NA	NA
56963:56979	attR	NA	NA	NA	NA
WP_042468972.1\|58305_59127_-	hypothetical protein	A0A219Y8Z3	Aeromonas_phage	4.9e-19	28.4
WP_005320938.1\|59710_59947_-	hypothetical protein	NA	NA	NA	NA
WP_042468965.1\|60160_60790_+	AAA family ATPase	A0A222YXS3	Escherichia_phage	5.9e-73	64.3
WP_005320934.1\|60789_61095_+	hypothetical protein	NA	NA	NA	NA
WP_042469084.1\|61258_64225_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	0.0e+00	71.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP022183

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

24585 : 55889

Vibrio_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|24585_25503_-\|transposase	IS5-like element ISAs4 family transposase	A0A1V0E8E1	Vibrio_phage	4.4e-93	55.8
WP_042469195.1\|25909_26548_+	AAA family ATPase	A0A222YXS3	Escherichia_phage	4.9e-43	44.8
WP_080697445.1\|26547_26838_+	CopG family transcriptional regulator	NA	NA	NA	NA
WP_088814097.1\|27053_27449_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|27493_28411_+\|transposase	IS5-like element ISAs4 family transposase	A0A1V0E8E1	Vibrio_phage	4.4e-93	55.8
WP_042468959.1\|28629_29349_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.6e-50	45.1
WP_042468955.1\|33115_33676_-	recombinase family protein	A0A1B0V7I5	Salmonella_phage	9.9e-48	83.1
WP_042468961.1\|33899_34169_+	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_042468953.1\|34168_34444_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_042468951.1\|35230_36145_+	TOMM precursor leader peptide-binding protein	NA	NA	NA	NA
WP_088814096.1\|36146_36332_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|36380_37298_+\|transposase	IS5-like element ISAs4 family transposase	A0A1V0E8E1	Vibrio_phage	4.4e-93	55.8
WP_088814095.1\|37492_38524_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_088814094.1\|38498_38693_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|38715_39633_-\|transposase	IS5-like element ISAs4 family transposase	A0A1V0E8E1	Vibrio_phage	4.4e-93	55.8
WP_005321183.1\|40128_40314_-	hypothetical protein	NA	NA	NA	NA
WP_043145146.1\|40443_40596_-	type I toxin-antitoxin system Hok family toxin	NA	NA	NA	NA
WP_005321180.1\|41046_41487_+	molecular chaperone Tir	NA	NA	NA	NA
WP_005321178.1\|41493_43680_+	type III secretion system effector protein kinase AopO	NA	NA	NA	NA
WP_076611341.1\|44117_45035_-\|transposase	IS5-like element ISAs4 family transposase	A0A1V0E8E1	Vibrio_phage	4.4e-93	55.8
WP_042469128.1\|45317_46076_+	ABC transporter permease	NA	NA	NA	NA
WP_042469126.1\|46731_47130_-	H-NS histone family protein	NA	NA	NA	NA
WP_043774562.1\|47852_48686_-	hypothetical protein	A0A219Y8Z3	Aeromonas_phage	1.0e-19	30.9
WP_005321586.1\|49471_50044_+	AAA family ATPase	NA	NA	NA	NA
WP_005321591.1\|50043_50391_+	hypothetical protein	NA	NA	NA	NA
WP_011898961.1\|50430_51645_-\|transposase	IS256-like element ISAs3 family transposase	A0A218MNI5	uncultured_virus	4.3e-48	47.9
WP_155268746.1\|51870_52008_-	hypothetical protein	NA	NA	NA	NA
WP_005320818.1\|53637_54087_-	Ati1 family type III secretion system chaperone	NA	NA	NA	NA
WP_011899437.1\|54860_55889_-\|transposase	IS110 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP022186

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022186_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_1

1339-1425

Orphan

Consensus_repeat	Method
TATTCCAACCTGATCCGAACCCT	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP022186_1

>merge|NZ_CP022186|1|1339-1425|CRISPRCasFinder
TATTCCAACCTGATCCGAACCCTCTCTTCCTGATATGACGGTGAGTGGACAGATGCAGCGCGAATATTCCAACCTGATCCGAAACCT

>NZ_CP022186|1|1|1339-1425|CRISPRCasFinder
TATTCCAACCTGATCCGAACCCT	CTCTTCCTGATATGACGGTGAGTGGACAGATGCAGCGCGAA
TATTCCAACCTGATCCGAAACCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005319532.1\|8540_8954_+\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|182691
NZ_CP022186.1\|WP_005319534.1\|7557_8262_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP022186.1\|WP_011898202.1\|2559_3663_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NZ_CP022186.1\|WP_005319540.1\|3659_6074_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	unknown	unknown	gnl\|CDD\|237860
NZ_CP022186.1\|WP_017411496.1\|6141_6906_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP022186.1\|WP_034281998.1\|7109_7487_-\|drug:proton-antiporter	unknown	unknown	gnl\|CDD\|319922
NZ_CP022186.1\|WP_005319542.1\|1453_2557_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NZ_CP022186.1\|WP_042467187.1\|10680_11106_-\|type-III-secretion-protein	unknown	unknown	gnl\|CDD\|341102
NZ_CP022186.1\|WP_042467186.1\|11218_12451_-\|valine--pyruvate-transaminase	unknown	unknown	gnl\|CDD\|236517
NZ_CP022186.1\|WP_042467190.1\|9047_9485_+\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|182691

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_005319532.1\|8540_8954_+\|Hsp20-family-protein	gnl\|CDD\|182691	PRK10743, PRK10743, heat shock chaperone IbpA.	7.51216e-68
NZ_CP022186.1\|WP_005319534.1\|7557_8262_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.82005e-64
NZ_CP022186.1\|WP_011898202.1\|2559_3663_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	2.94816e-139
NZ_CP022186.1\|WP_005319540.1\|3659_6074_+\|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B	gnl\|CDD\|237860	PRK14939, gyrB, DNA gyrase subunit B; Provisional.	0
NZ_CP022186.1\|WP_017411496.1\|6141_6906_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.06486e-06
NZ_CP022186.1\|WP_034281998.1\|7109_7487_-\|drug:proton-antiporter	gnl\|CDD\|319922	cd07261, EhpR_like, phenazine resistance protein, EhpR. Phenazine resistance protein (EhpR) in Enterobacter agglomerans confers resistance by binding D-alanyl-griseoluteic acid and acting as a chaperone involved in exporting the antibiotic rather than by altering it chemically. EhpR is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.	1.54675e-56
NZ_CP022186.1\|WP_005319542.1\|1453_2557_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	0
NZ_CP022186.1\|WP_042467187.1\|10680_11106_-\|type-III-secretion-protein	gnl\|CDD\|341102	cd17019, T3SC_IA_ShcA-like, Class IA type III secretion system chaperone protein, similar to Pseudomonas syringae chaperone protein ShcA. This family includes type III secretion system (T3SS) chaperone proteins similar to Pseudomonas syringae ShcA and similar proteins. In P. syringae, which is a plant pathogen that can infect a wide range of species, the T3SS allows injection of the effector HopA1 (previously known as HopPsyA or HrmA), a protein that has unknown functions in the host cell but possesses close homologs that trigger the plant hypersensitive response in resistant strains. Chaperone ShcA binding to Hop1A shows that interactions in animal pathogens are preserved in the Gram-negative pathogens of plants.	5.46284e-38
NZ_CP022186.1\|WP_042467186.1\|11218_12451_-\|valine--pyruvate-transaminase	gnl\|CDD\|236517	PRK09440, avtA, valine--pyruvate transaminase; Provisional.	0
NZ_CP022186.1\|WP_042467190.1\|9047_9485_+\|Hsp20-family-protein	gnl\|CDD\|182691	PRK10743, PRK10743, heat shock chaperone IbpA.	4.0303e-46

>NZ_CP022186.1|WP_005319542.1|1453_2557_+|DNA-polymerase-III-subunit-beta
MQLEISREALLRPLQLVSGALGGRPTLPILGNVLLDVSQGLLSLTGTDLEVEMIGQVYLNNESQDGRTTVPARKLLDICRGLPEGADIRLNTEGERLIIRSGRSRFNLSTLPASEYPNIEDWESVLEFDIGQLELKKLIDATQFSMASQDVRYYLNGMLFESEGHGLRTVATDGHRLATCRREVVEESLPDHQVILPRKGVLELVRLLEAEDKPVRLQIGRSNLRAALDGFIFTSKLVDGRFPDWRRVIPRNSDKALIAGREDLRQAFARAAILSNEKFRGVRLNLQENLLRITANNPEQEEAEELLDVQYEASEMEIGFNVSYVLDVLNTLKCDQIRISLSDSISSAIIEDFDHQDAQYVVMPMRI
>NZ_CP022186.1|WP_011898202.1|2559_3663_+|DNA-replication/repair-protein-RecF
MSLVKLQLSDFRNIQQASLKLSPGLNILVGCNGSGKTSVLEAIHYLGLGRSFRTHLTGRVIRQGERAFTLFAQCELEGRQVPIGLAKDKSGETQLKIAGAQAQRLADLAELLPVQLIHPDGFNLLTGGPQARRAWLDWGVFHQEPTFFSLWGRVRRLLKQRNALLRQSTQYRQLAFWDQELVRLGGELAEFRASYCQAITPLIKEMTADFLPEFDISLGFYRGWEKDTPLGDLLEAGFERDRTLGYTGVGPQKADVRLKANGVPAQDILSRGQLKLLVCAMRLAQGLYLNQHSSRGCIFLIDDFASELDVDKRRLLATRLKQCGSQVFITAIDTGQLADMMDANDCKLFHVEQGKISETLEKAESKL
>NZ_CP022186.1|WP_005319540.1|3659_6074_+|DNA-topoisomerase-(ATP-hydrolyzing)-subunit-B
MSENTYDSSNIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVFEVVDNSIDEALAGYCSDILVKIHSDGSVSVRDNGRGIPVDMHEEEGRSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLLLTIRRNGHVYEQTYHLGEPQAPLKQIGDSSSGTGTEVRFWPSPTIFTDTLYHYEILAKRLRELSFLNSGVSIRLQDERDGREVHFCYEGGIKAFVEYLNQNKTPIHPKVFHFSTEQDGIGVEVAMQWNDAYQEGVYCFTNNIPQRDGGTHLVGFRTALTRTLNTYMDKEDYSKKAKSAASGDDVREGLIAVISVKVPDPKFSSQTKDKLVSSEVKTAVEQAMGEKLGEFLLENPGDAKIVVNKIIDAARAREAARKARELTRRKGALDIAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMISSQEVGTLITALGCGIGRDEYNPDKLRYHNIIIMTDADVDGAHIRTLLLTFFYRQMPEIIERGYIYIAQPPLYKVKKGKQEQYLKDEDALLQYQTAMALDGATLHVNESAPPIGGEALERLVNQHRAVSHLITRMSRRAPDAVLTQLIYQPELNETLLASESDLLAWCQGMEAVLNESNHGIQYQIQVRRDEERSLFVPHAVVRQHGVDREYAISYDFLQSSEYRQLVSLGKEIANLIEDGGFIKRGEKVKPIANFVEAVDWLMGEGKRGIYIQRYKGLGEMNPDQLWETTMDPEARRMLRVTIDDAVGADQLFSTLMGDAVEPRRDFIETNALRVANLDV
>NZ_CP022186.1|WP_017411496.1|6141_6906_-|GNAT-family-N-acetyltransferase
MTSRHNSLRLYQPTNSTPDELTEQQLALFTLLQLREQEFGFNPNVIVHYPEAGFLGSPIGYLNQLIGEQLQQGYFINQVVILTTYQVLSSPLMQAGYQHEAVHMPAGPDHTAIFRWQCGTHPAGKTLYVEVVNEQDPKIRPTFVLMLRDEHGKLLGGMSGSIWTKEEHRYAYIGTVVVQPGQPAGTGTRLANTVLEYLSLQKVCEINLGTQTAEPFYTRLGFRAIHHIVPALRHRTTKDGTELPHNLVIMSKLL
>NZ_CP022186.1|WP_034281998.1|7109_7487_-|drug:proton-antiporter
MLVPQFTILYVANPARSALFYRELFGHPPVEESPTFAMFVFESGARLALWSSATVEPAVTQSAGAMELAFPLPNEASVDTGLAEWRARGLTILQQPTKMEFGYTGMALDPDGHRLRLYCPGAEPV
>NZ_CP022186.1|WP_005319534.1|7557_8262_-|YafY-family-transcriptional-regulator
MSRSERLLALLQLLRGHRYAITGTELASQLGISMRTLYRDIATLQAQGAHIEGEPGIGYVLRPGFMLPPLMFSEDELEALVLGSRWVVAHCDEALSASASSALAKIEAVLPAEYRQQLQANALLIGTSRSDSPVDEAPLRSAIRQQRKVTLSYRDLKEELSERTVWPFALGYFEQVRVLVAWCELRQGFRHFRVDRIAWMQLEDNRYPKSRESLLKEWRATQQIPQPKFIADRN
>NZ_CP022186.1|WP_005319532.1|8540_8954_+|Hsp20-family-protein
MRSIDFSPLYRSAIGFDRLANLIESAASNGNAGYPPYNIEQLSDNDYRISMAVAGFTQEELELSFQENLLTVKGSKQAESDRNYLYQGIAERGFERRFQLADYVRVKGADLKNGLLHIELMREVPEAMKPRKIEING
>NZ_CP022186.1|WP_042467190.1|9047_9485_+|Hsp20-family-protein
MRNLDFSHLYSNAVGFERMARELEGLFEQKAAAYPPYNIEKREHDSYRITLAVAGFEREELELETENGTLKVKGCKAAAGERQFLHQGIAERDFELAFKLSQHVEVQGAKLEHGLLTIDLARELPEALKPRAIEIGKPDQLALPG
>NZ_CP022186.1|WP_042467187.1|10680_11106_-|type-III-secretion-protein
MDIGEILLAELATQLQLSSLTIDENGNCPLLIDSELPLILHLEPCALLIMAPLVLPTFSFDNAELQRRMLMAALNPAFDKEPGIGWHPEFQLIAYRRHMLDGMTGSQLAQHLGDFIEWMRKFVTSLPRSTPATTRGIHDRV
>NZ_CP022186.1|WP_042467186.1|11218_12451_-|valine--pyruvate-transaminase
MEFSLFGEKFTRHAGITQLMDDLNQGLTNPDAIMLGGGNPAPIPAMLERFQTEARNLLDNGELVKAMANYDGPQGKDRFTKALATLLSKELGWNITSRNIALTNGSQNAFFYLFNLLAGEFADGRKKKVLFPLAPEYIGYADSALADDYFVAYKPTIEKLPDGQFKYHVDFESLQVGDDIGVICVSRPTNPTGNVLTDEEIEHLDQIARDKGIPLLIDNAYGVPFPGIIFSEAKPFWNANTILCMSLSKLGLPGTRCGIVIADEKIIQAITNLSGIISLGPAITIPMIESGEIIALSEQVVKPFYKQKADFAVQLLRDAIPDPRFHIHKPEGALFLWLWFEGLPIHSQELYERLKAKNLLIVPGHYFFPGIDDPEWRHSQECIRLNYSQSEELVRRGIAILADEINALYV

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP022186_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_2

87035-87128

Orphan

Consensus_repeat	Method
GGAGAAACAGCTCGAGATTGCGAAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022186_2

>merge|NZ_CP022186|2|87035-87128|CRISPRCasFinder
GGAGAAACAGCTCGAGATTGCGAAGATCCATCTTTCTATTCCTGCGGCGGCGCGTTTGCTGGCGTGGGGGAGAAACAGCTTGAGATTGCGAAGA

>NZ_CP022186|2|2|87035-87128|CRISPRCasFinder
GGAGAAACAGCTCGAGATTGCGAAGA	TCCATCTTTCTATTCCTGCGGCGGCGCGTTTGCTGGCGTGGG
GGAGAAACAGCTTGAGATTGCGAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005321271.1\|95731_95968_+\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP022186.1\|WP_042468352.1\|85310_86183_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366132
NZ_CP022186.1\|WP_005321295.1\|91313_92150_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|182386
NZ_CP022186.1\|WP_042468351.1\|82284_84855_-\|bifunctional-acetate--CoA-ligase-family-protein/GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223972
NZ_CP022186.1\|WP_005321672.1\|68907_70032_-\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NZ_CP022186.1\|WP_005321308.1\|84946_85138_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_017412961.1\|70028_70538_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NZ_CP022186.1\|WP_005321651.1\|75068_75860_+\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NZ_CP022186.1\|WP_005321297.1\|90963_91152_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_042468353.1\|87253_88735_+\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235368
NZ_CP022186.1\|WP_005321654.1\|73116_74952_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|236730
NZ_CP022186.1\|WP_005321293.1\|92300_92897_-\|nucleoid-occlusion-factor-SlmA	unknown	unknown	gnl\|CDD\|181894
NZ_CP022186.1\|WP_005321291.1\|92966_93425_-\|dUTP-diphosphatase	unknown	unknown	gnl\|CDD\|234802
NZ_CP022186.1\|WP_005321282.1\|93570_94773_-\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513
NZ_CP022186.1\|WP_017411691.1\|94920_95595_+\|JAB-domain-containing-protein	unknown	unknown	gnl\|CDD\|178801
NZ_CP022186.1\|WP_005321666.1\|70600_70903_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005321658.1\|71947_72850_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176120
NZ_CP022186.1\|WP_005321648.1\|75878_76370_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|240845
NZ_CP022186.1\|WP_005321299.1\|88891_90541_-\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
NZ_CP022186.1\|WP_005307500.1\|95979_96147_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|179075

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_005321271.1\|95731_95968_+\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	3.10301e-34
NZ_CP022186.1\|WP_042468352.1\|85310_86183_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|366132	pfam00497, SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3.	5.25801e-07
NZ_CP022186.1\|WP_005321648.1\|75878_76370_-\|RNA-binding-protein	gnl\|CDD\|240845	cd12399, RRM_HP0827_like, RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins. This subfamily corresponds to the RRM of H. pylori HP0827, a putative ssDNA-binding protein 12rnp2 precursor, containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The ssDNA binding may be important in activation of HP0827. .	9.92965e-31
NZ_CP022186.1\|WP_042468351.1\|82284_84855_-\|bifunctional-acetate--CoA-ligase-family-protein/GNAT-family-N-acetyltransferase	gnl\|CDD\|223972	COG1042, COG1042, Acyl-CoA synthetase (NDP forming) [Energy production and conversion].	2.21318e-162
NZ_CP022186.1\|WP_005321672.1\|68907_70032_-\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	9.72148e-176
NZ_CP022186.1\|WP_005321651.1\|75068_75860_+\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	5.6724e-109
NZ_CP022186.1\|WP_017412961.1\|70028_70538_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	9.2067e-81
NZ_CP022186.1\|WP_042468353.1\|87253_88735_+\|ketol-acid-reductoisomerase	gnl\|CDD\|235368	PRK05225, PRK05225, ketol-acid reductoisomerase; Validated.	0
NZ_CP022186.1\|WP_005321654.1\|73116_74952_+\|TonB-dependent-receptor	gnl\|CDD\|236730	PRK10641, btuB, TonB-dependent vitamin B12 receptor BtuB.	2.85797e-178
NZ_CP022186.1\|WP_005321293.1\|92300_92897_-\|nucleoid-occlusion-factor-SlmA	gnl\|CDD\|181894	PRK09480, slmA, division inhibitor protein; Provisional.	5.35e-120
NZ_CP022186.1\|WP_005321291.1\|92966_93425_-\|dUTP-diphosphatase	gnl\|CDD\|234802	PRK00601, dut, dUTP diphosphatase.	5.7864e-97
NZ_CP022186.1\|WP_005321282.1\|93570_94773_-\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
NZ_CP022186.1\|WP_017411691.1\|94920_95595_+\|JAB-domain-containing-protein	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	9.16629e-136
NZ_CP022186.1\|WP_005321658.1\|71947_72850_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176120	cd08429, PBP2_NhaR, The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold. NhaR is a positive regulator of the LysR family and is known to be an activator of the nhaA gene encoding a Na(+)/H(+) antiporter. In Escherichia coli, NhaA is the vital antiporter that protects against high sodium stress, and it is essential for growth in high sodium levels, while NhaB becomes essential only if NhaA is not available. The nhaA gene of nhaAR operon is induced by monovalent cations. The nhaR of the operon activates nhaAR, as well as the osmC transcription which is induced at elevated osmolarity. OsmC is transcribed from the two overlapping promoters (osmCp1 and osmP2) and that NhaR is shown to activate only the expression of osmCp1. NhaR also activates the transcription of the pgaABCD operon which is required for production of the biofilm adhesion, poly-beta-1,6-N-acetyl-d-glucosamine (PGA) .Thus, it is suggested that NhaR has an extended role in promoting bacterial survival. This substrate-binding domain has significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.59501e-81
NZ_CP022186.1\|WP_005321295.1\|91313_92150_-\|mechanosensitive-ion-channel	gnl\|CDD\|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	7.02959e-94
NZ_CP022186.1\|WP_005321299.1\|88891_90541_-\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP022186.1\|WP_005307500.1\|95979_96147_+\|50S-ribosomal-protein-L33	gnl\|CDD\|179075	PRK00595, rpmG, 50S ribosomal protein L33; Validated.	7.40188e-23

>NZ_CP022186.1|WP_042468352.1|85310_86183_+|transporter-substrate-binding-domain-containing-protein
MIRILLWCITLFAGSALAAESHIRAWNLLLEHPNPAVAGLLRLSLDLTVPEYGPYQLIASPPMEQGRAVKALQEGALVQIGVFAPDEERERSLLAVHIPLAKGLLGWRVCLIRLGDEGRFSGIGSLADWHSAGLTIGQHRSWPDTRLLKANGLKVTVGNLYEALFNMLSKRRFDCFLRSVIEIEDELKQHPELAIEPHLVFRYPLALLFFVSPQYPELAQRLELGLQRARQSGAFDQIFEKEFGSTIRRLKLDERVMLELHNPDLPARSRIMMADPSLIYAPVTATPSAQ
>NZ_CP022186.1|WP_005321308.1|84946_85138_-|hypothetical-protein
MMRHLIEINSSQLFEEYLQSLGVPQTLLDHEQDIYLQERPLAAVRQIQGKMKFYLRAGALTKQ
>NZ_CP022186.1|WP_042468351.1|82284_84855_-|bifunctional-acetate--CoA-ligase-family-protein/GNAT-family-N-acetyltransferase
MKPSGLDRLFKPHSIAVIGASTDPQKAGHVVIRHLLAGQFKGPILPVSPHNKAIAGVLAYPDIASLPLSPDLAIICTKRERVLSLIEALGKKGAGAAIILAADFSQEEREQLQRLSSQYDIRLLGPNSMGMLLPAQGINASFSPIAAKPGQVAFVSQSAAVSTTILDWAKQHELGFSAFISLGDHCDIDFGQLLDQLSRDGTTRAILLYMDKLHDARHFLSAARAASRNKPILVLKSGRHDPAKGLDNVYDAAIRRAGMLRVRDTHELFAAVETLSHSLTLKGERLAIISNGRGLANMAVDVLLERGGKLAIPPKDIGSDADITAYQQALDALLQGNEADAILLIHAPSLTARGAELARSLIDYLRQHPRARRFNILTNWAGEYSAQEGRKLFTEAGIPTYRTPESAVAAFMHMVEYRRNQKQLIETPASLQGDKLNVELCQQLIRQALERKQLTLDTHLVQPILQAAGLATLPTWIVSDAIEATLTAEQIGYPVAVKLRSPDIAHKSAVHGVMLNLRTSAEVAQAADAILDRVRQHDAGARIEGLLVQRMARRSGGLELRIRLQQDPVFGPVILLGESGAEPQEMVAALPPLNQALARYQVIGALKSRKIREQATPERLDIDALGQVLCQLSELLLAFPEIQELDLHPLQACGAEMVILDASLTLMPMTQQRCPLAIRPYPTELEEGAWLKDQSHVLLRPIRPEDEPAHKQFVLKVSDEDRYKRFFADVGELGHEELARMTQIDYDREMAFVAVGQDGAFSQQILGVVRAISNPDQSDAEFAILVRSDLKGLGLGKLMMEKIVRYARERGIGQLSGMTMPSNRGMINLAKRLGFKIDIQLEDGVVNMELPCAERA
>NZ_CP022186.1|WP_005321648.1|75878_76370_-|RNA-binding-protein
MNLSKFPVYVQAAILALVLALVGYLVAQALQFSLKAEVIFAVGLAIGGFIVPLFLKRTPAAAGELASGQETCTLYVGNLPYRANEIAVRELFAEQGQVISVRLMKDKATGKRRGFGFVEMPAADAAKAIAVLNDKEYQQRTLKVREANDKRDKDEREGSEVDA
>NZ_CP022186.1|WP_005321651.1|75068_75860_+|glutamate-racemase
MANILVFDSGMGGLTIYREIRRALPAHNYFYCFDNANFPYGELSESALIAACTRLVSHMVAEHVIDLVVIACNTASTIALPSLRAALTIPVVGVVPAIKPAAALTRNGCIGLLATPGTVSREYTHHLIAQFAPGKRVLLKGATELVIEAEHKLAGRPVNMALLQEVLTDWMEGEERPDTLVLGCTHFPLLNDEIRQLMPGCQLVDSGSAVARRVAHLLATVAEQPSQAVVQARAYCTRLDAQAQKLTAPLQAWGLSSLEEVQY
>NZ_CP022186.1|WP_005321654.1|73116_74952_+|TonB-dependent-receptor
MSKTLLVAALLPTAAFAQTTIAVNPTLVITANRVEQPISSVLAPVVVIDRAEIESRQVQSLPALLKTLPGVQITTLGGRGHMSSLFIRGTNSNHSLVLMNGRPIAAMVAGTPDLSQIPLGNIERIEYIRGPRAAVYGADAIGGVINLITKTSAKNGSETHLKGGVGSNGYGQGQVRTVQALGQQTDMNMMIGYERTDGFDVVANAQQPDRDGFDSLNGQFGLNHGFSDAWSGDFNAQGYDNQTEMDDAYQSADQSRVQAFQYDGGLKFQSETLTSRLEASYGENKLKSWLESKGESSAQPIHTGLTRFSWINSWSGVEGLNLTGGADWQQEQLKSDSRSSGLAFNAPDRDNTGLFAVGSYRWQALLWELSGRTDDNEQYGRHNTWSAASGLDIDDNHNVRLSYGTGFKAPTFLDLYYPGYENPDLKPEESKNLELGFAGRYTGWDWSLNLYRNKIQNLIACQSAFSTCKPDNTDAEIRGVEVALGLETGPIHHDLSFDYTRAEDKNDGDQQLLRRAKQKASWLTQVQLGPVDLSTELLYVGKRDDKNFSSFPAERVELGSYTLINLGASYGVTPQLTLGGRIDNLFDRDYAPAYGYASAGTEFKLTADYRL
>NZ_CP022186.1|WP_005321658.1|71947_72850_+|LysR-family-transcriptional-regulator
MLNYKQLYYFWHVARSGSVTRAAEQLHLTPQTISGQVAELELSLGVALFSREGRRLVLTAAGRQALEQAGAIFSLGAELEHTLRHASQELTMQVGIADSVPRTLAFELLAPAMALATPVRLICHEERAEQLFSELARHKLDMVLIDRPLPPDSGVRGYNHELGRSPLALFASPALAARARSGFPASLEGLPLLIPGEKSATHDRLLAWYRQQGIHPHLVGQFDDSTLMKSFGKAGMGIFPAPLAMRDEIERLYGVERIATLPEVTLSYYLVSAGRHLSHPGVQAVMEGARQRLVELEKQK
>NZ_CP022186.1|WP_005321666.1|70600_70903_-|hypothetical-protein
MQTETRTLLTVITEANLEPTLLRTLTREGLRGYTITDARGRGDHGERNASWSESGNIRLEAICSREQAERLLAHLQSRYYPDYAMIAFLQPVEIVRPEKF
>NZ_CP022186.1|WP_017412961.1|70028_70538_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MNTPPLIGLVMGSDSDWPVLQAAARILKEHGVPYEARVVSAHRTPDLLFEYAASARDRGLRAIIAGAGGAAHLPGMVAAKTTVPVLGVPIPSRHLKGMDSLLSIVQMPKGVPVATFAIGEAGAANAALFAVSLLSVTLDGDAPRYQQQLDDFRANERDRVLALQLEDPA
>NZ_CP022186.1|WP_005321672.1|68907_70032_-|5-(carboxyamino)imidazole-ribonucleotide-synthase
MILPPATLGMLGGGQLGRYFVMAAHRLGYKVVVLDPDPASIAGAAADHHIVAPYDDQTALHDLASRCAAISCEFENVPAATLALLEKQKPMRPAASAVRICQDRREEKAFLRGADIPVAPHLALLAGDPIPAQASALFPAILKTAREGYDGKGQWQVGNLDELASALTASGVPCVLEKRLPLEGEFALTLARSPSGAISALPLVQNWHSGGILDQTRSPANVPALEAEAKDIAERLIAVLDYVGVLTVEFFLVEGRLLVNEMAPRPHNSGHPSLDNAECSQFELQVRALCDLPLPEKAEVRPAILLNLLGDLWHGGTPDWEGVLALPGVHLHLYGKGEARPGRKMGHVTITGRDWPTVEDTSRHVRSLLGLPPP
>NZ_CP022186.1|WP_042468353.1|87253_88735_+|ketol-acid-reductoisomerase
MANYFNTLNLRQQLAQLGKCRFMQRAEFADGCDVLKGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKAAITEKRASWQKATDNGFAVGTYEELIPTADLVLNLTPDKQHSDVVKTVMPLMKQGAALGYSHGFNVVEEGQQIRADITVVMVAPKCPGTEVREEYKRGFGVPTLLAVHPENDPKGVGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCYDKLVAEGTDPAYAGKLIQFGWETITEALKQGGISLMMDRLSNPAKLRAFELSEQLRTLMRPLFEKHMDDIIAGEFSRGMMADWAEDDAKLFGWREETGKSAFENAPAFAGKIAEQEYFDNGVVMVAMVKAGVELAFETMVASGIYEESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYGNYLFANAAVPLLREHFMPTLKAGDLGASKAEGQNVDNLALLAANEATRNHPIEKIGQVLRGYMKDMKRIAVGG
>NZ_CP022186.1|WP_005321299.1|88891_90541_-|glucose-6-phosphate-isomerase
MKNINPTQTQAWQALEAHFAANKETRLKDLFAQDPKRFDKFSLTFGGDILVDYSKNLITEETLKLLVDLAKETDLRSAIDAMFNGEKINMTEGRSVLHVALRNRSDRPIECDGKDVMPEVNAVLAKMKGFCEKIISGEWKGYTGKAIQHVVNIGIGGSDLGPVMITEALRPYKNHLQMHFVSNVDGTHIAETLKEIDAETTLFLVASKTFTTQETMTNALTARDWFIKIAGDKAHVAKHFAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSSWSAIGMPIALSVGFDNFEALLQGAFEMDMHFATASYEQNVPVLLALIGLWYNNFHGAESEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGNPVDHQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFLAPAISHNPIGDHHPKLLANFFAQTEALAFGKSKEQVEAEFLAAGKTLEQVEDLVPFKVFEGNRPTNSILFKSLTPKTLGALIAMYEHKIFVQGAIWNIFSFDQWGVELGKQLANKILPELNTAEAVTSHDCSTNGLINTWKAWKA
>NZ_CP022186.1|WP_005321297.1|90963_91152_+|hypothetical-protein
MKHVLSLFALSLIATGLIGLLTLALTAAAPTLEIRVLAVIGAVLGGYALVQPLLNRVARRLL
>NZ_CP022186.1|WP_005321295.1|91313_92150_-|mechanosensitive-ion-channel
MEPEIITEAQTWLVNNQGLLIEYAVNIAAALITLLVGYITANLLSNGVIKVMNARKLDATVTHFVGSILKYTILVFVVIAAMGRVGVQTASFVAIIGAAGLAIGLALQGSLSNFAAGFLLIIFRPIKAGEFIEVAGTNGVVQSVQLFTTTLTSGDNKMVVVPNSAILNGTIVNYSRMDTRRVDMTFGIGYGSDLRKAKQLLERLVSEEPRILKEQAATIAVAALADSSVNIVVRPWVKTADYWGVWFDFHEKVKLTFDAEGIEIPFPQMVMHMQKPQA
>NZ_CP022186.1|WP_005321293.1|92300_92897_-|nucleoid-occlusion-factor-SlmA
MASSNQKQSRRDQILQALAHMLETSPGQRITTARLAAEVGVSEAALYRHFPSKARMFEGLIDFIEDSLLSRVNLIMAEEKDTMARCHHILQLLLVFAERNPGITRILNGDALLGEHDRLRDRISILFDKLETQIKQVLREKRLREGQGFQLDETMLANLLLAYTEGRISQFVRSEFKLKPTAGFEDQWLFIRSQLLQS
>NZ_CP022186.1|WP_005321291.1|92966_93425_-|dUTP-diphosphatase
MTTQIELKILDARIGTEYPLPAYATPGSAGMDLRALLDAPITLAPGDTILVPTGLAIHIQDPGLCATILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSVWNRGNDSFTMQPGERIAQLVIMPVVQASFQLVDEFNQSERGEGGFGSSGRQ
>NZ_CP022186.1|WP_005321282.1|93570_94773_-|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MRLADKRILLGVSGGIAAYKSAELVRRLKDQGAEVRVVMTRSAKEFITPLTLQAVSGHPVADSLLDPAAEAGMGHIELAKWADLVLIAPASANLMARMAAGMADELLTTLCVATPAPVALAPAMNQQMYLNAATQANLKTLASRGILLWGPDSGSQACGDVGPGRMLDPLELVERCCQQLAAEPLLAGVRLLLTAGPTREALDPVRYISNHSSGKMGYAIARAAREAGAEVTLVSGPVALPAPSGVERVDVESAEQMHQAVMSRVGECDLFIGCAAVADYRPEQVASQKIKKTGDNDQMVLTLVKNPDIIAAVGALSDKPFTVGFAAETVDVEQYALDKLQRKRLDMIAANDVSRAGQGFNADDNALTVFWQGGQAPLPLADKLTLARHLIALIARHYRR
>NZ_CP022186.1|WP_017411691.1|94920_95595_+|JAB-domain-containing-protein
MSIKEWPEDERPREKLLRQGPATLSDAELLAIFLRTGVNGLSAVDLSRQLLQQFGSLRALLGADQGAFCHAHGLGPAKYAQLQAVLEMGKRHLAEQLQRGDALTSPQLTRDYLQAQLRDRPREVFALLLLDNQHRVIQFVELFYGTLDSASVWPREIVQIALKHNAAAVILAHNHPSGVAEPSRADRQITDRILAALALIDIRVLDHLVIGDGITVSFAERGWL
>NZ_CP022186.1|WP_005321271.1|95731_95968_+|50S-ribosomal-protein-L28
MSRVCQVTGKRPAVGNNRSHANNATKRRFLPNLHTHRFWVEGEKRFVSLRVSAKGMRIIDKRGVEVVLAELRASGVKV
>NZ_CP022186.1|WP_005307500.1|95979_96147_+|50S-ribosomal-protein-L33
MAKGIREKIRLNSSAGTGHFYTTTKNKRTMPEKMEIKKFDPVVRQHVIYKEGKIK

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Crispr_ID: NZ_CP022186_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_3

1059323-1059435

Orphan

Consensus_repeat	Method
AGAAACAGGGGCCTAGTGCCCCTGTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022186_3

>merge|NZ_CP022186|3|1059323-1059435|CRISPRCasFinder
AGAAACAGGGGCCTAGTGCCCCTGTTTTGTTAGGTTAATCCCCCTGTAAATACAGGGTCTGATGTGCTTGATATGTTAACCCCCCAGAAACAGGGGCCTGGTGCCCCTGTTTT

>NZ_CP022186|3|3|1059323-1059435|CRISPRCasFinder
AGAAACAGGGGCCTAGTGCCCCTGTTTT	GTTAGGTTAATCCCCCTGTAAATACAGGGTCTGATGTGCTTGATATGTTAACCCCCC
AGAAACAGGGGCCTGGTGCCCCTGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005311632.1\|1067952_1069317_+\|dGTPase	unknown	unknown	gnl\|CDD\|235320
NZ_CP022186.1\|WP_085941500.1\|1061399_1062299_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP022186.1\|WP_042467243.1\|1063074_1063512_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|334445
NZ_CP022186.1\|WP_088814159.1\|1046555_1047665_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|273203
NZ_CP022186.1\|WP_005311623.1\|1062370_1063003_+\|DUF2057-domain-containing-protein	unknown	unknown	gnl\|CDD\|378258
NZ_CP022186.1\|WP_005311630.1\|1065584_1067897_+\|aerobic-respiration-two-component-sensor-histidine-kinase-ArcB	unknown	unknown	gnl\|CDD\|236842
NZ_CP022186.1\|WP_011899053.1\|1054586_1055027_+\|DUF412-domain-containing-protein	unknown	unknown	gnl\|CDD\|377248
NZ_CP022186.1\|WP_005311635.1\|1069639_1069843_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005311626.1\|1063610_1064309_+\|DUF3334-family-protein	unknown	unknown	gnl\|CDD\|314646
NZ_CP022186.1\|WP_005311610.1\|1056031_1056496_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|181857
NZ_CP022186.1\|WP_017412149.1\|1055087_1055588_-\|YfbU-family-protein	unknown	unknown	gnl\|CDD\|180087
NZ_CP022186.1\|WP_005311601.1\|1047701_1047854_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_042467242.1\|1060699_1061302_-\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|236057
NZ_CP022186.1\|WP_005311612.1\|1057319_1058207_+\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NZ_CP022186.1\|WP_042467240.1\|1050862_1053016_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NZ_CP022186.1\|WP_005311611.1\|1056518_1057052_-\|glycine-cleavage-system-transcriptional-repressor	unknown	unknown	gnl\|CDD\|236935
NZ_CP022186.1\|WP_034283655.1\|1064378_1065377_-\|DUF2860-domain-containing-protein	unknown	unknown	gnl\|CDD\|371359
NZ_CP022186.1\|WP_088814357.1\|1059455_1060571_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|184420
NZ_CP022186.1\|WP_005311605.1\|1049962_1050457_+\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NZ_CP022186.1\|WP_042467238.1\|1048244_1049963_+\|acetolactate-synthase-3-large-subunit	unknown	unknown	gnl\|CDD\|181602

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_085941500.1\|1061399_1062299_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.24107e-55
NZ_CP022186.1\|WP_042467243.1\|1063074_1063512_+\|HIT-domain-containing-protein	gnl\|CDD\|334445	pfam01230, HIT, HIT domain.	1.54167e-19
NZ_CP022186.1\|WP_088814159.1\|1046555_1047665_+\|glycosyltransferase	gnl\|CDD\|273203	TIGR00661, conserved_hypothetical_protein, conserved hypothetical protein. This model represents nearly the full length of MJ1255 from Methanococcus jannaschii and of an unpublished protein from Vibrio cholerae, as well as the C-terminal half of a protein from Methanobacterium thermoautotrophicum. A small region (~50 amino acids) within the domain appears related to a family of sugar transferases. [Hypothetical proteins, Conserved].	2.62873e-83
NZ_CP022186.1\|WP_005311623.1\|1062370_1063003_+\|DUF2057-domain-containing-protein	gnl\|CDD\|378258	pfam09829, DUF2057, Uncharacterized protein conserved in bacteria (DUF2057). This domain, found in various prokaryotic proteins, has no known function.	1.10247e-39
NZ_CP022186.1\|WP_005311630.1\|1065584_1067897_+\|aerobic-respiration-two-component-sensor-histidine-kinase-ArcB	gnl\|CDD\|236842	PRK11091, PRK11091, aerobic respiration control sensor protein ArcB; Provisional.	0
NZ_CP022186.1\|WP_011899053.1\|1054586_1055027_+\|DUF412-domain-containing-protein	gnl\|CDD\|377248	pfam04217, DUF412, Protein of unknown function, DUF412. This family consists of bacterial proteins, including yfbV from E. coli. YfbV is a membrane protien involved in insulating the chromosome from the TerR macrodomain.	2.85575e-63
NZ_CP022186.1\|WP_005311626.1\|1063610_1064309_+\|DUF3334-family-protein	gnl\|CDD\|314646	pfam11813, DUF3334, Protein of unknown function (DUF3334). This family of proteins are functionally uncharacterized. This family is only found in bacteria. Proteins in this family are typically between 227 to 238 amino acids in length.	1.73798e-148
NZ_CP022186.1\|WP_005311610.1\|1056031_1056496_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|181857	PRK09437, bcp, thioredoxin-dependent thiol peroxidase; Reviewed.	6.82136e-106
NZ_CP022186.1\|WP_017412149.1\|1055087_1055588_-\|YfbU-family-protein	gnl\|CDD\|180087	PRK05445, PRK05445, YfbU family protein.	3.22814e-85
NZ_CP022186.1\|WP_005311632.1\|1067952_1069317_+\|dGTPase	gnl\|CDD\|235320	PRK04926, dgt, deoxyguanosinetriphosphate triphosphohydrolase; Provisional.	0
NZ_CP022186.1\|WP_042467242.1\|1060699_1061302_-\|short-chain-dehydrogenase	gnl\|CDD\|236057	PRK07578, PRK07578, short chain dehydrogenase; Provisional.	3.90635e-124
NZ_CP022186.1\|WP_005311612.1\|1057319_1058207_+\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	3.47266e-164
NZ_CP022186.1\|WP_042467240.1\|1050862_1053016_-\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_CP022186.1\|WP_005311611.1\|1056518_1057052_-\|glycine-cleavage-system-transcriptional-repressor	gnl\|CDD\|236935	PRK11589, gcvR, glycine cleavage system transcriptional repressor; Provisional.	8.05624e-47
NZ_CP022186.1\|WP_034283655.1\|1064378_1065377_-\|DUF2860-domain-containing-protein	gnl\|CDD\|371359	pfam11059, DUF2860, Protein of unknown function (DUF2860). This bacterial family of proteins has no known function.	2.97984e-69
NZ_CP022186.1\|WP_088814357.1\|1059455_1060571_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|184420	PRK13960, PRK13960, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_CP022186.1\|WP_005311605.1\|1049962_1050457_+\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	6.20447e-96
NZ_CP022186.1\|WP_042467238.1\|1048244_1049963_+\|acetolactate-synthase-3-large-subunit	gnl\|CDD\|181602	PRK08979, PRK08979, acetolactate synthase 3 large subunit.	0

>NZ_CP022186.1|WP_005311612.1|1057319_1058207_+|4-hydroxy-tetrahydrodipicolinate-synthase
MLRGSLVALVTPMLASGEVDWASLATLVDYHVSAGTAAIVAVGTTGESVTLSEQEHIAVVEKTVELAAGRIPVIAGCGSNNTAHAIALAKRFAETGVVAGLSVTPYYNKPTQEGLYRHYCAIAEASGLPQILYNVPSRTCCDLKPETVARLARVPGIIGLKEATGDLSRTPLLRELCGEEFALYSGDDASGCDFMLQGGDGVISVTTNIAAAQMADMCRAALAGDAGQAHDINNRLMPLHQTLFCEPSPIPVKWACARLGLIATATLRLPLTDLTPEGEQAMTRALTTAELMASV
>NZ_CP022186.1|WP_005311611.1|1056518_1057052_-|glycine-cleavage-system-transcriptional-repressor
MTHYLVVTAIGTDRPGIVNEVTRHVSGCGCNIVDSRLGIFGNEFTFIMLLSGDWNSLMQLEISLPLRSQEWELITMMKRTERHHSLQYDISANAEILIRDQPGIVSQCTQFFSDHGWDIQAMQTMTLEQQPYNLLKASFQLNLAKQGEAAGSDTAFAGFCRELGAESFEFIVNNKHA
>NZ_CP022186.1|WP_005311610.1|1056031_1056496_-|thioredoxin-dependent-thiol-peroxidase
MQPLSAGTLAPDFSLSDQDGNPVRLSDLRGKKVLIYFYPKAMTPGCTTQACGLRDVNSELAALNVVVLGISPDPAKHLKKFEERDSLNFRLLADEDHAVADAFGVWGPKKFMGKEYDGIHRLSFLIDEEGKIAHRFDKFKTSDHHQVVLDLIKG
>NZ_CP022186.1|WP_017412149.1|1055087_1055588_-|YfbU-family-protein
MNMSHTERLILSNQYEILAKLNPEKAASYQRASTIIARGYCLQILELEKSFGHLDLATCQEVIDTLELHHALAISWGNLDGADQSEITASRLEFNGYSRSQERELADYVCFLLEVDKRFPELKCPCDELSSDIAMRDKYQRMLTVWRQCPRQYKLSIQEIRKVLAA
>NZ_CP022186.1|WP_011899053.1|1054586_1055027_+|DUF412-domain-containing-protein
MSMNIFGTKLQQGRHYMTLWPRRPELNSMFPENRVIKATEFALKIIPALAVLSVMLQFQLGELHYWPSVMTSVLFLLSLPLQGYYWLGQRADTRLPPSLASWYREINGKMNEQGSHRQLVAQPRYEELADTLNAAFKQLDKSFLYE
>NZ_CP022186.1|WP_042467240.1|1050862_1053016_-|phosphate-acetyltransferase
MARTIMLIPVGTGVGVTSVSLGVVRAMERHGVNVSFFKPVAQPRPGETGTERSTAVIRAAANINPPEPFALSYAENMITSSNTDILLEEIVARFEEHVKASGAEVLVIEGMVPTDKQPFANKLNYDVAKALDADMVFVTHPGNDSSQKLKERIELACSNFGGVNNPRIVGCVINKVGAPVDEHGVTRPDLTEMFEAHHHASEAAHNLEVLQVFGKSPLRILGCIPWNTQLIAPRAKDLAKHLAAKILHKGELDSRRLQTVTFCARSIHNMVEHFRPGSLLVTSGDRSDVIVSACLSAMNGVKLGALLLTGNYHPEPQVMALCQQAMATGLPIMITGTNTWQTAVSLQNFNVDIPEDDRERIELVQDYVAGHIDKHWIESLSAKSTRSRRLSPPAFRYQLTELARQANKRVVLPEGEEPRTIKAASICAERGIARPVLLGNPEEIRRVAEQQGVVLTDRVEIIDPLEVRERYVPRLVELRKNKGMTEVVAREQLEDNVVLGTMMLERGEVDGLVSGAVHTTANTIRPPMQIIKTAPGSSLISSIFFMLLPDQVLVYGDCAINPDPTAEQLAEIAIQSADSAAAFGIEPRVAMISYSTGTSGAGADVEKVREATELAKAKRPDLIIDGPLQYDAAIMENVAKSKAPNSPVAGKATVFVFPDLNTGNTTYKAVQRSADLVSIGPMLQGMRKPVNDLSRGALVDDIVYTIALTGIQAAQAE
>NZ_CP022186.1|WP_005311605.1|1049962_1050457_+|acetolactate-synthase-small-subunit
MRHIISVLLENESGALSRVVGLFSQRGYNIETLTVAPTEDPTLSRMTIVTMGDERVLEQIQKQLHKLVDVLKVCDLSEGEHIEREIALVKARAAGGARDELKRLADIFRGQIVDVTPEQYTVQLVGTSEKLDAFIKTAAQTNEIIEVVRSGVCGISRADKALRP
>NZ_CP022186.1|WP_042467238.1|1048244_1049963_+|acetolactate-synthase-3-large-subunit
MEMLSGAQMVVRALEDQGVEHVFGYPGGSVLDIYDALFENGKMEHVLVRHEQAAVHMADGYARSTGKVGTVLVTSGPGATNCITGIATAYMDSIPLVILSGQVPTSMIGEDAFQETDMIGISRPVVKHSFLCKKASDIPDAIKKAYYIAASGRPGPVVVDLPKDVQNPKEKFPYQYPETVSLRSYNPTKAGHKGQIKRAAKLLVDAQRPVMYVGGGAINANADHLVTKLAELLNLPVTTTLMGLGAFSGTHPQFVGMLGMHGTFEANKTMHNADLIFAVGARFDDRVTNNVAKFCPNATIVHIDIDPTSISKTVQAHVPIVGSVETVLEQMLEVIRECGFDNDKQALADWWSQIAQWRSRNCLAYETHPTLIKPQQVIETLYKVTKGEAFVASDVGQHQMFAALYYPFTKPRQWINSGGLGTMGFGIPAAMGAQFANPGAVVCCVTGDGSVQMNIQELSTCMQYGVPIKIISINNRALGMVKQWQKMFYGGRHSHSYMESLPDFVKLAEAYGHVGIAVSDPAELESAMEKAFAIKDRLVFMDISVDPDEHVYPMQIKFGAMDEMWLSKTERT
>NZ_CP022186.1|WP_005311601.1|1047701_1047854_+|hypothetical-protein
MRFTNENGDTMTLADNLTLHELLDMGVSISVCEETDPDQQIWLAESEDEQ
>NZ_CP022186.1|WP_088814159.1|1046555_1047665_+|glycosyltransferase
MRILFGVQGTGNGHISRSRTLARALRAQGLEVDYLFSGRPADDYFEMDEFGDYRTFAGITFVSHEGAISGWRTLKGLSPLRFWRDMRALDCRDYDLVISDFEPLSAHAAHRWGKPSLTISHQASFDWPIPRWGESGFNRQLMRHFAPVRQSLGLHWFHFGQPLLPPIIDPIVALPDNQQILVYLPFEQTEAIAALLSRFNQQRFVCFHPAIRSASQWRNIRFEPQAREGFKQVLAGCRGVITNGGFELASEALSLGKKLLVKPLGGQFEQLTNSKTLELMGLAHLMDGLDANAVRAWLDASAPGQILYPDVAGELASWLAAGAEESVAQLSRRLWARTLFPEEVCDRLSELEGGCALNSTWLSQVSAFD
>NZ_CP022186.1|WP_088814357.1|1059455_1060571_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MLLAMSLADQVLAVNDDLPIRTDKPVHSGKVRSVYWLTPEDSARLIKEKGYDVPADAPLALMVISDRISAFDCIWQGVDGLNGVPGKGAALNAISSHWFKLFKEKGLADSHILDIPHPFVWIVQKARPVMIEAIARQCITGSMWRAYKDGEREFCGITLPEGLKKDQKLPEILITPSTKGVLTGLDGVPEADDVNVSRADIERHYQGFNFSKPADIDRYEVLLKEGFNVISDALASLDQIFVDTKFEFGYVQDAAGNEKLIYMDEVGTPDSSRIWDGAALRDGQIVEKSKEGFRQWLLNHFPDPDILLNKNRMPERFALAKGNKLPTEVMMDISNTYVGIAEKIIGHPLVRSANPKQEIIEVLRDQYGLID
>NZ_CP022186.1|WP_042467242.1|1060699_1061302_-|short-chain-dehydrogenase
MKIVIVGASGTVGSAVSELLAKEHQVIRVGHSRGDATVDMRDPASIKALFALVGQFDALVVASGSVAFNGLTEMTDEQWQVGLQSKLMGQINLTRAAIPYLNDKGSITLISGILSEEPINWGVSATTINGAIEHFVKAAACELPKGLRINVVSPTVLTESMDKYADFFPGFVPVPAAKVALAYQKSVLGVQTGQVFKVNG
>NZ_CP022186.1|WP_085941500.1|1061399_1062299_+|LysR-family-transcriptional-regulator
MDIAHLASFYEVVQRGSFSAAADVLGVSKGMLSRHVSALEAALNAQLLQRTTRRLSLTEAGKTLYLQTGQIFALVRQAEEDIQALTEEDAGRLRFTCAVSTGDRMVSELLGHFAVLCPGVEVELNFTNAMVDMSQGENDIALRAMSSIPDNLVALPLGQLKDVVVASPALLVREGIPATPYELSSRPCLLQGSNPAWEQWHFRRGEEEAHILVQGKVRANHYSTVLQLARAGMGYAKCPLMLVEPALAAGELVTVLDGWQSGLHQLHVLHAQQRRVPRKIRLFKQVLAQWFAERPRYLL
>NZ_CP022186.1|WP_005311623.1|1062370_1063003_+|DUF2057-domain-containing-protein
MKGYQKWSGLTLLWSALGMSTAQAAVEVVVPPDFQILAVSAGKLQDEQHATLADGEQQLLVRYEGVIPSRNSSENDRQVRSDPQVVRYQASNQRLTLVAQQPADEQAMVAYAKAPVVTLQANGQALDTQQDALMTSGMLIGMDWRARLEEYNRSGGKAALTMAGVATTVAAGKAVPAVATSELEGRLQQLFLQADPELRKRFVGWAVPRL
>NZ_CP022186.1|WP_042467243.1|1063074_1063512_+|HIT-domain-containing-protein
MFELHTRLQADTQLLGDLPLCRVLLAKDSQYPWLILVPRVDNLREIHHLVPAQQQQLMQESCAVATLMEQALSPDKINIGALGNLVPQLHLHHVARFTTDKAWPGPIWGAHPALPYDPQALRTQADSWRARLAHLAGFIPLCVDN
>NZ_CP022186.1|WP_005311626.1|1063610_1064309_+|DUF3334-family-protein
MIVTRADNDAVLTTEDVLLSLCHSVTGVLSAATQSQVRFSGMVQRISKTCLKPDIGCFVLFDGGFSGLVVINFSASAAMELYESYMLSMGLSKEDLAISHTSDEVSNVMGELMNQIVGSFTVKVGRDLQTHITQNQPKMLALNKQVMLSVDTNLDNPEARRVTFFTSRNNIFYLELAMDRTEFIRIHSDGMDEEELDPDALIAQTKLAASKPTPVAAKVANEHDDLLDSLGI
>NZ_CP022186.1|WP_034283655.1|1064378_1065377_-|DUF2860-domain-containing-protein
MRTLTLLSLGLLAANAAHADLGEIPKQSGWSGFLLGGVNAVSYKSNFYAGDDSNSRINDLGSPDSESGLTPLINADIRYTFADTRTQVFLGNLIQDAIRFDFTQQLGLRQEMGDKGIVATSLVFNAMPVELWSDPFATNVDRSSTDVKSKGVRFTWDKIWGSNFHGSLTSREVDLDEERSGQQYDLTHGTHYASMLDRNGKVHDMEISYQWHFGGNQLLEPAILYKQARLDGSAESFKNTGLQLTYAKRGPQWSIVSNVYAGKRNYDEANPIFGQSADANEFAINGTFFWHSLFGVKDLAATFTAAYSTANSDISFYDSQATRVSTGLLYNF
>NZ_CP022186.1|WP_005311630.1|1065584_1067897_+|aerobic-respiration-two-component-sensor-histidine-kinase-ArcB
MKQIKSWAQYYVDLMTKLGLVRFSMFLATGIIVLAVSIQMGVTLFLRGTVDIVDLVRSVFFGLLVTPWAVYFLSIVVDQLEDSRQRLTRMVRKLQDMRERDLELNSQLQENISRLNAQIAETNRAETLRQQAIEDLENEVFQREKAQLHLGERTALLRSFIDCSPDLVYYRNEDEQFSGCNRAMEELTGRVEAELIGLTPFDVYKQEIANKVVETDKQVFTSNEPLTYEQWLEYPDGRKAYFELRKVPFFDRFGKRLGLLGFGRDITERKQYQDKLEKASRDKTTFISTISHELRTPLNGIVGLSRMLMDTPLDPRQHQQLKTIHLSAVTLGNIFNDIIDLDKLDRRRLEIAPTPIDLPAFLDELETLSRIQAEQKGLYLHFDRDGDMPQFVMADGTRLRQVLWNLVGNAVKFTDEGGVTVRCLSHAADVPGKLALHFEVEDTGVGIPRAQQEKIFAMYYQVQGKKHATGTGIGLAVSRQLVQAMGGQLYVDSDPGEGSCFTAELEVDCVEPQVATSEQEMPTLDILLVEDVELNVTVACALLNKLGHEVKVARDGAQALAMANPDDFDLILLDIQLPDMTGFDVAAQLLARYGDSLPPMVALTANATGDRQYYRDRGLQDVISKPLGSRAVREVIGHLFADLADDEADEQADAGNQDALLDLAFLTDYADTVGKPVLLSSVELFEKMMPDYMAVLDSNMIAKDQAGVVEEAHKIKGAAGSIGLRRLQQLAQLIQSPDHPAWWENVEDWIESLRRECPGDIARLKRWLLS
>NZ_CP022186.1|WP_005311632.1|1067952_1069317_+|dGTPase
MYQRLIPSLRSHPWGEEELLEATELDRARIVQAAPVRRLQQKTQVFPLDVKASVRSRLTHSLEVQETGRQISRRILAALPAGAVCEGAFINLVEMSCLLHDVGNPPFGHFGEQVMSQWLTQELDTLFAAALGQAPSPQWAELRQDLLVFDGNAQSLRLVHSLHELNLTLGQLAALCKYPQQPQPGLHYGQHHGWTSKRGIFFSEQPLYRSLSQSLGLAPGCRHPLVYIMEAADDISYCIADLEDAVDRRILSLSELQQALRLADAGSYMAVLLADATASDRGFFPHFRQHLTHDLIALAAHTYVSEHEIILSGAYPQALLHGQAPAAMVLDTLKQVAREQVFMRPEVEALELEGYAALRGVLSTYACLLALPASQFERLLAGQGGSELFFARRLFHRLSARHLKAYRLAVASRDPRFDSGAEQEWYYRVRLLLDYVSGMTDTYALEEFRLLSGI
>NZ_CP022186.1|WP_005311635.1|1069639_1069843_+|hypothetical-protein
MSIELALLRTVESLVQKRITRLERRISYLHLSPALLKDIGLEGQNVQIAHIREQEYQTGFRLGNRIT

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Crispr_ID: NZ_CP022186_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_4

1771446-1771541

Orphan

Consensus_repeat	Method
TGCAATGGAGCTGCATATGTGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022186_4

>merge|NZ_CP022186|4|1771446-1771541|CRISPRCasFinder
TGCAATGGAGCTGCATATGTGTGGTTTTAAAGAATATGGAGCCCCTGCTTGGGAGGGGCGAGCCCACTCAATGTGCAATGGAGCTGCATATGTTTG

>NZ_CP022186|4|4|1771446-1771541|CRISPRCasFinder
TGCAATGGAGCTGCATATGTGTG	GTTTTAAAGAATATGGAGCCCCTGCTTGGGAGGGGCGAGCCCACTCAATG
TGCAATGGAGCTGCATATGTTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005310125.1\|1766603_1766954_+\|arsenate-reductase-(glutaredoxin)	unknown	unknown	gnl\|CDD\|239332
NZ_CP022186.1\|WP_005310145.1\|1774690_1775476_-\|pyruvate-formate-lyase-1-activating-protein	unknown	unknown	gnl\|CDD\|182994
NZ_CP022186.1\|WP_005310131.1\|1768150_1769053_-\|lysine-exporter-LysO-family-protein	unknown	unknown	gnl\|CDD\|225287
NZ_CP022186.1\|WP_005310135.1\|1770404_1771178_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270421
NZ_CP022186.1\|WP_005310143.1\|1773961_1774603_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225775
NZ_CP022186.1\|WP_088822008.1\|1780396_1785364_+\|alpha-2-macroglobulin-family-protein	unknown	unknown	gnl\|CDD\|225248
NZ_CP022186.1\|WP_005310119.1\|1764053_1764287_-\|sulfurtransferase-TusA-family-protein	unknown	unknown	gnl\|CDD\|376492
NZ_CP022186.1\|WP_042468012.1\|1766065_1766545_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP022186.1\|WP_088814205.1\|1775541_1778520_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP022186.1\|WP_017412017.1\|1778615_1780304_+\|CoA-disulfide-reductase	unknown	unknown	gnl\|CDD\|163244
NZ_CP022186.1\|WP_157668956.1\|1767366_1768008_-\|DUF479-domain-containing-protein	unknown	unknown	gnl\|CDD\|225666
NZ_CP022186.1\|WP_042468015.1\|1762957_1764028_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP022186.1\|WP_005310127.1\|1766950_1767346_+\|DUF2069-domain-containing-protein	unknown	unknown	gnl\|CDD\|378269
NZ_CP022186.1\|WP_005310139.1\|1772278_1772971_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226634
NZ_CP022186.1\|WP_011898880.1\|1787799_1788759_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_080697392.1\|1785422_1787726_+\|penicillin-binding-protein-1C	unknown	unknown	gnl\|CDD\|183049
NZ_CP022186.1\|WP_005310141.1\|1773332_1773857_+\|acyloxyacyl-hydrolase	unknown	unknown	gnl\|CDD\|378181
NZ_CP022186.1\|WP_088814366.1\|1764466_1765870_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|227122
NZ_CP022186.1\|WP_042468004.1\|1788936_1790385_+\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234932
NZ_CP022186.1\|WP_005310133.1\|1769584_1770355_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226961

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_005310125.1\|1766603_1766954_+\|arsenate-reductase-(glutaredoxin)	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	3.36982e-52
NZ_CP022186.1\|WP_005310145.1\|1774690_1775476_-\|pyruvate-formate-lyase-1-activating-protein	gnl\|CDD\|182994	PRK11145, pflA, pyruvate formate lyase 1-activating protein.	0
NZ_CP022186.1\|WP_005310131.1\|1768150_1769053_-\|lysine-exporter-LysO-family-protein	gnl\|CDD\|225287	COG2431, COG2431, Predicted membrane protein [Function unknown].	9.8385e-78
NZ_CP022186.1\|WP_005310135.1\|1770404_1771178_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270421	cd13703, PBP2_HisJ_LAO, Substrate binding domain of ABC-type histidine- and lysine/arginine/ornithine transporters; the type 2 periplasmic-binding protein fold. This subgroup includes the periplasmic-binding proteins, HisJ and LAO, that serve as initial receptors in the ABC transport of histidine and lysine-arginine-ornithine amino acids. They are belong to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.44832e-127
NZ_CP022186.1\|WP_005310143.1\|1773961_1774603_-\|hypothetical-protein	gnl\|CDD\|225775	COG3235, COG3235, Predicted membrane protein [Function unknown].	2.84487e-33
NZ_CP022186.1\|WP_088822008.1\|1780396_1785364_+\|alpha-2-macroglobulin-family-protein	gnl\|CDD\|225248	COG2373, COG2373, Large extracellular alpha-helical protein [General function prediction only].	0
NZ_CP022186.1\|WP_005310119.1\|1764053_1764287_-\|sulfurtransferase-TusA-family-protein	gnl\|CDD\|376492	pfam01206, TusA, Sulfurtransferase TusA. This family includes the TusA sulfurtransferases.	5.30781e-18
NZ_CP022186.1\|WP_042468012.1\|1766065_1766545_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.00934e-24
NZ_CP022186.1\|WP_088814205.1\|1775541_1778520_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	5.65035e-101
NZ_CP022186.1\|WP_017412017.1\|1778615_1780304_+\|CoA-disulfide-reductase	gnl\|CDD\|163244	TIGR03385, Coenzyme_A_disulfide_reductase, CoA-disulfide reductase. Members of this protein family are CoA-disulfide reductase (EC 1.8.1.14), as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. [Cellular processes, Detoxification].	3.52599e-160
NZ_CP022186.1\|WP_157668956.1\|1767366_1768008_-\|DUF479-domain-containing-protein	gnl\|CDD\|225666	COG3124, COG3124, Uncharacterized protein conserved in bacteria [Function unknown].	8.35552e-47
NZ_CP022186.1\|WP_042468015.1\|1762957_1764028_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	5.34249e-60
NZ_CP022186.1\|WP_005310127.1\|1766950_1767346_+\|DUF2069-domain-containing-protein	gnl\|CDD\|378269	pfam09842, DUF2069, Predicted membrane protein (DUF2069). This domain, found in various prokaryotes, has no known function.	4.09151e-37
NZ_CP022186.1\|WP_005310139.1\|1772278_1772971_+\|ABC-transporter-permease	gnl\|CDD\|226634	COG4160, ArtM, ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism].	2.52099e-99
NZ_CP022186.1\|WP_080697392.1\|1785422_1787726_+\|penicillin-binding-protein-1C	gnl\|CDD\|183049	PRK11240, PRK11240, penicillin-binding protein 1C; Provisional.	0
NZ_CP022186.1\|WP_005310141.1\|1773332_1773857_+\|acyloxyacyl-hydrolase	gnl\|CDD\|378181	pfam09411, PagL, Lipid A 3-O-deacylase (PagL). PagL is an outer membrane protein with lipid A 3-O-deacylase activity. It forms an 8 stranded beta barrel structure.	1.62055e-11
NZ_CP022186.1\|WP_088814366.1\|1764466_1765870_+\|M48-family-metallopeptidase	gnl\|CDD\|227122	COG4783, COG4783, Putative Zn-dependent protease, contains TPR repeats [General function prediction only].	2.36194e-145
NZ_CP022186.1\|WP_042468004.1\|1788936_1790385_+\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234932	PRK01269, PRK01269, tRNA s(4)U8 sulfurtransferase; Provisional.	0
NZ_CP022186.1\|WP_005310133.1\|1769584_1770355_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226961	COG4598, HisP, ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism].	2.05006e-161

>NZ_CP022186.1|WP_005310135.1|1770404_1771178_+|ABC-transporter-substrate-binding-protein
MNKLMLATAIVTALSSGSLMAKEWKEVRIGVEGAYPPFSWTEPSGEVKGFDIDIANALCAEMKVKCTLVKQDWDGIIPALLSRKYDAIIATMDITEERKKKVDFTQKYQHIPARFAAKKGTDVQLDKAFMDGKAVAVQRATSMDTYITDNFPNATIKRYGTADEAYLDLKSGRVDYVLADSAAITDGLLKKEGGDGFEFVGPKLTDPKWFGEGAGIAVRKADKDLKEKFNTAILALRANGKYKEINDKYFEFDVYGE
>NZ_CP022186.1|WP_005310133.1|1769584_1770355_+|ABC-transporter-ATP-binding-protein
MSDVAALEVRELHKYFGTHEVLKGIDMTAHKGDVISLIGSSGSGKSTFLRCINLLETPSSGTVSLHGELIRMKTNRAGERLAEDVRQVERIRSRLAMVFQSFNLWSHMTIMQNIIEVPIQVLKIPRAEAIAKAEHLLNRVGLWERRDYYPGHLSGGQQQRAAIARALAVDPEVMLFDEPTSALDPELVGEVLGLMRELAEEGRTMLVVTHEMSFARDVSNKVMFLHQGRVEEEGNPKEIFAHPKSERFKQFISSIY
>NZ_CP022186.1|WP_005310131.1|1768150_1769053_-|lysine-exporter-LysO-family-protein
MLLNVLLILLPLAIGYLIPLSSARLIKLVNQSLGKMVYLILFLMGLGLAYVENLGSNLAVIFKVAGVMLAAITFCNLLALWWLDKRSPPTHEASDAKMPSKRHLLWESLQLCFVVLGGVLLGLLVDLRILPIDKLSEWALMLLLLLIGVQMRNSGMRLRQILLNPWGMKIAFTVIVSSWLGSLLAAQLLGMPFSHGLAISSSFGWYSLSGILVADKLGPVLGSAAFINDLGRELIAILIIPMLMHRHPSAAIGYGGATALDFTLPVIQKSGGIQVVPVAIVSGFILSLLGPILILGFLAI
>NZ_CP022186.1|WP_157668956.1|1767366_1768008_-|DUF479-domain-containing-protein
MNYLAHLHLAAHTRSSLTGNLLGDFIKGPLPSALAPEFDEGIWLHRKIDAFTDAHPEHRAAVACFEAPWRRFGGILVDMLYDHWLSVHWPQFCAEPLPRFLQHSYDQLLADHLLLADGLPAALKRMAEQNWIASYRHKEGLGRALNGIGHRLRRPVLLGDALTTLDEMDWHTCELGFLRFYPQLMAFTRPLSRDRRPRRLAAIKNRTLGPVCR
>NZ_CP022186.1|WP_005310127.1|1766950_1767346_+|DUF2069-domain-containing-protein
MTTRFARLLTLVGFFGLLGWVILWHLFLSPHPDLNPWLLPVIWTVPLLFPLKGIVQGNPYTHAWGNFVLMPYFLHALTLITTDEGERWLAVVELVFTTLAFVGTIYYARLRGRELGLSIRKKKGELSQEEK
>NZ_CP022186.1|WP_005310125.1|1766603_1766954_+|arsenate-reductase-(glutaredoxin)
MSETQIYHNPRCSKSRETLALLEQHGIAPDVVLYLEQAPSEDVIRTLLTQLGFADPRQLIRTKEDLYKELGLADQSGDALIRAMHQHPKLIERPIVIKDGKARIGRPPEQVLEILK
>NZ_CP022186.1|WP_042468012.1|1766065_1766545_-|TlpA-family-protein-disulfide-reductase
MVRVSGRAQEMKRICWMIVAALLTACSPAPEFSNGQGQPVTLAQFAGKPLLVNYFAPWCVPCLRELPLLETLAQEGKIAVVVNSYDPATPAELGALASRHHIRVPLLIADKEAHLPFSLPTGLPTSYLLDGEGRLQATLVGELDGQKIAALKLRAAQFR
>NZ_CP022186.1|WP_088814366.1|1764466_1765870_+|M48-family-metallopeptidase
MGATFHAQANNQLPDIGTAGVAALPIEQEVRYGNAFMRFARAGLPIIDDPVLSQYIDDLGQRLLTNADGVRFPFTFFLVNDPSINAAAFLGGRVKVHTGLFLYADSESELASVLAHEITHVTQRHIARYMEAQASSSAMTLAGLVGSIALAVINPTAGIAALQTTLGLSMQSAINYTRDNEYEADRIGMKTLYDAGFDPMGMANFFQKLAAEYRYASKPPQMLLTHPLPETRISEARGRANSYGRRNLPPSLDFWLAKVRIQVRYGTETPQALLSYFDSRLQKGDYPLKDAATYGKALALLQLKRTDEADTLMQELATRHPEDLFVVDALTDIDLAKGRSAQAIARLEKFRARMPDNEVVVVNLGNAYLEGGDYKKSIAILDPYARDHEENSLAWNLLSDAYRKAGRMTELHMARAEMLSLRGDYQAAIDELIVARGTTSDKLTLARLEARITELERAKKDLDSLKG
>NZ_CP022186.1|WP_005310119.1|1764053_1764287_-|sulfurtransferase-TusA-family-protein
MEHLDLTPWRCPEPLIRLKLWLRQATPGQSLSIQLADPGSRQDIPAYLQRQGHTVTLQQGPDNTIFLQLVVGAKQPS
>NZ_CP022186.1|WP_042468015.1|1762957_1764028_-|AI-2E-family-transporter
MLEVLKRWYQTRFSDPDAVTLFLLLVACFAVLWLFGGLLAPLLVALVMAYLLEWPVSRLQRAGLSRALATSLVLLLFIAVTVMALLGLIPTLVSQGINLAKESPSMLAHAQDYVRTLPEKYPEVIDVTLVETIIDNIRQRILSGGEHLVSASLSSLVNVVAILIYLILVPLMVFFMLKDKQELMGGLRRFLPRNRTLVNRVWVEMNDQIINYIRGKVIEILIVGVATYIPFALMGLRYSALLAVAVGFSVLIPYIGAAAVTVPVAMVALFQWGLTPEFTWLMVAYLVIQALDGNLLVPLLFSEAVNLHPVAIIVAVLVFGGLWGFWGVFFAIPLATLVKAVINAWPKRDDPALPGV
>NZ_CP022186.1|WP_005310139.1|1772278_1772971_+|ABC-transporter-permease
MDFSIILKEWPTYWQGLYTTVLLVAASLILGLALAVPMGILRNSRNWLIKGPIWAYIYFFRGTPLLVQLFIIYYGAAQWEWLKNSAAWTLFAEAWFCALLAFTLNTGAYTAEIVRGAVLNMPKGQIEAANAFGMSRWQTLTRIILPNSFRRALPAYSNEVIFMLQGSAVAGIITIVDLTGAARIINSRYYSPFEAFLTAGLLYMLLTFVIVWLFKKWEARWHAHLRPRSL
>NZ_CP022186.1|WP_005310141.1|1773332_1773857_+|acyloxyacyl-hydrolase
MRANTLLLSGLLASLIASTGAIANDNIVALQLGTPSENEKLSIFTADAKYHHMFWRWGDSGCQFGLGVRGGMLKAGDERTARLGTGARAECLWGNWVVWLPAEVIWLADHEFGHRGNGFKDYGGPFQFVTGIGLGYAITKNWLIGYQYEHMSNANMYEQNPGLDTHTLHIEYRF
>NZ_CP022186.1|WP_005310143.1|1773961_1774603_-|hypothetical-protein
MSEGQAAALLLWVLLLIFSLRGTLLRTLLNQPLYQHLCLGGAIVLVPLWTLRAGLHEGLEVHFLGLTSLTLLLGWRLALLAPCLTLLVLGYFGVASLADFGWQALIGIALPVATSWLLFLASWAWMPRHLFVYLFVVAFFGGALSISVKMIASALLMGMSGAYPWHTISADYLSIWPLLLFPEALLNGMTMTLLAVYRPHWVNTFFDREYLGR
>NZ_CP022186.1|WP_005310145.1|1774690_1775476_-|pyruvate-formate-lyase-1-activating-protein
MSVSNQIPAVETSESGVIGRIHSVETCGTVDGPGIRFIVFMQGCLMRCKYCHNRDTWDTQGGREVTVPELMSDITSYRHFMNASGGGVTASGGEAMLQQNFIAELFAACKEKGVHTCLDTNGFVRHYDEQLDKVLDNTDLVLLDIKQINDEKHIPLTHVSNKYTLEFARYLAAKGKTMWIRYVVVPTWSDDDESAEGLGQFIAELGDSVEKVELLPYHELGKHKWDVLGENYDLTGIKPPSKETMDRVQGILAKYHNNVKY
>NZ_CP022186.1|WP_088814205.1|1775541_1778520_-|EAL-domain-containing-protein
MPPDSCSTGCYQFMSSTALSHLPPASQTPLFFRLDVRSQRLVALTDVMQTPLHWLDEPRSAWPAQLPDALRLPIEQALAKGQGGKLMLRFAGQQWHIALSHEQDAFWLICLQTQRQEPIADLALQLPRLSQMASQQQFVAMLEALKESLGADRLILWHYQANGSLGSEQLTPVFALGAEGLSAIRGDSRYIRALRTRKSLSFSEAAHQPMLSQHYYLANAGVSSRLDGALLEQEKLIGVLSLEYLSATVLSEEMLQLVRHSAQLLGHWQPEPEPIINPVLALPGELTLLTGIAYCRALVNWAVTMSGARIGWVGEYQPRDQELWIIPRCVLEGETFSILKPIQLDPGPAQELFQHGQALYVEDLPLRYPLATQLLALNAKAYVGVPLHGPSGAPMGQLTLLLDTPLADPMPLLDALSSQHERAAIELQRLAADDALRLAEVAFNTHDGLLVMDHQGIILKVNHSFGRITGFGNDEMIGQHIVRLRPTYYGDHLKEDVRRAIDEQEFWMGEERCLHKDGHLFPVRLMVSGVKDELGEFSHYVCSFYDITKEKDAARHIEQLAYYDDLCGLYNRRSLNNIMQCTLQAPNGQWGALLLVDLDNFKSINDSLGHACGDQLLQAVVERLKGLPQDNLVLARIPGDEFALLFTALGQGYVTAKILAEHFARELMGLFRTPFDIEDHKLHCSASVGISLFSSEDQDHLVLMQQADTATHMAKRAGQGNYVFFSEAMAEKEKSKLTINNQLRDALRHHELQLHYQPQYRVDNGSLSGIEALLRWQRSDGTMVPPAEFIPIAEETSLIQDIGYWVMKTACAQYSFWLNRGFAIPHLSVNVSARQFHTAGFVQQVEYILRDTGVPPSRLLLEVTESVVLENRLESIARMRQLKELGILLSIDDFGTGYSSLAYLRDLPADEVKLDRSFIQTLVHSEQDKAIVKAILDLAKVFRFTVTAEGVEDEEQLAILKTLGCQHYQGFLTSRPLTVKALESLLGAAQSG
>NZ_CP022186.1|WP_017412017.1|1778615_1780304_+|CoA-disulfide-reductase
MKRILIVGGVAGGASAAARARRLSEEAEIVVFERGEFVSFANCGLPYHIGGDIQDRDALLLQTPQSFKRRFNVDVRVFHDVIEIDKAGKTLLVRNLQTGEERREPYDQLLLSPGAAPIRPPFPGIDSPHVYTLRNIPDMDRILAALQHDHPRHVTVVGGGFIGLEMMEALHQRKLEVTLLELSDQVMAPVDKEMANMLHARIREEGIDLRLRTGLAAIESLDVLAEKTAAVASATRSGLRLTLSDGSHLETGLLILAIGVKPETLLAAKAGLELGPRGGIKVDAGMRTSDPFIHAVGDAVEETDFVTGESVLIPLAGPANRQGRIAADNMLGRAETYKKTQGTAICKLFDLAVASTGLNEKRLVQLGLPFEKAYVHPGSHASYYPGAHPVSLKLLFAPDGKIYGAQAIGKDGVDKRIDVLAVAQRAGLTVFDLQDLELTYAPPFGSAKDVINMAGFVASNHLKGDTILCHAAEVQARHPHQQVLDVRNGPELDKLGRIPGALHIPLDELRGRLNELPRDKELLISCQVGLRGHVACRLLSQHGFKVKNLSGGFKTWQMAVMD
>NZ_CP022186.1|WP_088822008.1|1780396_1785364_+|alpha-2-macroglobulin-family-protein
MCQASRMSYPVAYRAAMAAIQSGMEPMRPFDPRPAAHQCAHAFVSPLRRRWSALLLTGLTGLLLAGCGQDKPAATADQAPAARQVAGVPDTVVQANARQYRDAPALALVFSGPLAPKSNWQTWLSVSEGGKQLQGEWVLAEDGRTLYFPQVAPDKSYKVTLKAGLGPEAQSWTLKTRPLEAGASFAASGMVLPLRQELRLPISAVNVDEVNIDFFRVDAEYLPRFLAEYRPGAGMGNWELEQITSRAKRVFSGRYALELDPNRRETRLINVKEPQLAEAGVYFAVMSPLGNYDWRKETTYFAVSDMGLSARRYRDQLEVFVSALSSADPLKEVQLSLLDEKGNRLLVQQTDLRGHRRFDQVQGARLLLAEQGKHLAVLRLDGAALDLSAFELGTQPWQAQQLYLFSGRDLYRPGERLDSEILLKGQDGQLLPGMAVELEVKQPDGQLLEQKRLLPDSLGAAHYGLRLPDDAPLGRWTITLKTAAGSRFEWPFLVEEFLPERLKLQLGKGPDGELLNPQEALTLPLQGDYLYGAPASATKAKAEVKISRATMPFNQWQEFTLGDVLLTEQARDLEPVTLTLDKQGHGAFSLVDQLASVGTLGPLEVAYRVSLSEPGGRAVNRSRTQYGWPTGSQWPALKADFVADRVEGGKTLPFQILNLDEQGQPVAGEVKVRLVNEYRDYYWHYADGEGWKYEFNSQPYLEQEQTLQLDGKGPTTLSLPLAAGWYRLEVENSQGHQSSLRVEIGSYAWGGGGEQARPDKIAITLDKRAYQAGDKAKVTLVAPRAGKGLLLVEDGDGLRWWQRIELRPEGAGLAEARGEFEIPVSPEWQRHDLHISAQIAAPDSESKPVSQKSVQSLRSVGLVPLALDREARRLPLTLSAPDKAVPLTRLEVAVTSTPNSQGRVVLAAVDRGVLNISDYQPLDPFEIFFGRKRFAQDLFDNYGQVIPPQDGKLARLNYGGDAPALKKGGALESRVEVAALWSGEVSFDESGKAVIPLDLPNFNGELALMALAWNEQQVGQAERAVKVVAPLVAEIGWPRFGARGDETRGLVQLRNMSGEDQSLSLTWTLTGGLQARGALPETLALKNGEERWLTLPLTVTGASGVARLQLAASGKDFAVNREWSLPLRSPWPAQTRQRYQMLAPNQQMSFAQSELAGLDPANLQGLLSLSGTPPWDPTGQWQALAQYPYACLEQTLSRAWPYLLTTADERAAWSNNLPNVDKPVSEADLQRALLQRLQRLQLPGGGFGLWDGRSDEEQWLTAYAADYLLTRKEAGDAVPEAMLSQAISRLQSYLGDSQYGERWSSAPEHSRLAYQAYSAFVLARVGKAPLSTLRLIWEQQADHARSGLPLLHLSLALSAMGDEQTAAKALTRALATPRGDDYLADYGSPLRDGALELALLRQHKLAEDRWPELSAKVADTLAHRQWLSTQERLALLRLAQVDPAADWQARVASISGGQAVAGKNSAQIGAPEALAATGVTNEGKGSLYVQRTLVGYPEQAPVRISQGMSVTRSWFNADGKQLDPAKVKVGDFVVVRLNVSSEQTVPDALLVEMLPAGFELENPALGTSIKLEELSIEGKPAWQSEWNDYLKHQEFRDDRYTAALDLSEGGNQQLVYLMRAVTPGRYQVPPTQVEDMYRPELRAVGQDIHEVTISE
>NZ_CP022186.1|WP_080697392.1|1785422_1787726_+|penicillin-binding-protein-1C
MHQGRLALPGLPRWLRLTGLGMGALILVLLVLDRAFPPPPLDPAYARVVLDMKGRPLRAFADTSGVWRYPVTLEQVSPRYIEALLGYEDRHFWRHPGVNPVAMVRGVWQWLRYGRAVSGGSTLTMQVARLIEPYHRSVPGKLRQMARALQLEWHYDKRTLLTVYLNRAPFGGNLEGVQAASFAYLGKSAAKLTHAEAALLAVLPQAPSRYRPDRHPDRARAARDKVMQRLVKQGAWPDAVWREGRIEPVLARGHFTPMEAPLFARLAADSQPGALVHTTIDGDLQRWLEARVATYIRRFPEQTSAALLLVDNQTMAVRAYVGSAEYGNLRRHGYLDMVQAIRSPGSTLKPFIYGLALDAGLVHSASLLSDAPRLGSDYRPANFTGAFQGPVTLTRALQQSLNVPAVQVLEALGPDTLVNRLDNAGVRLALSDKPNPAIALGAAGVRLEQLVALYSSLTRQGQVAMPVWLAGQQAVSRPLLSPGAAWITWQILSSQGRADQPFASEATGRVNRLAWKTGTSYGYRDSWALGVSGRWTLGVWLGRPDGTPLPGFYGQSAAVPLLLSVYSRLGDNSPLPAQPNTVSEAEICWPLGRRVSATLPEACLQHQSAWLLDEQDPPTLPDPMDWPSPLRQVALTSQGKPTLTRCDDASQSVWRALWPLSLEPWRAPGERRKALLASGCEGEAQEADLQAPIRIVALGEGNLIRSQRYRLQPRVLGGVGKPFWFLNGQRLRWDGDQVLSKAGRYQLVVVDEAGNSDRVEFRLENPS
>NZ_CP022186.1|WP_011898880.1|1787799_1788759_-|hypothetical-protein
MKTYIYYPGMEVRDELWLKFALLYLERLAFVFTISEKSGLTTLLSTLEQRTDLLAERPEPAFFADITPQLESQLGGLVAPDFARHKVFGNRDLITRWRQSANHDCFCPTQAGLERLHGFCLAHGFASQDEGGIKMARRFANLLSMRLAREWALANEGALITDHDYLDRLLHLLESRYHNRGGQDCFHLEIPLRVPTHLSEISFDELIALRARSGFRQQLAEFHQALDAMLTMLGSGYAEPAALTRFELAQQGLNQLLGPATHSLPLTTLISCSLPAMAMIHQLKASHPASNLIFHPIKKSHFHQRKSQHFFTRLGQVKS
>NZ_CP022186.1|WP_042468004.1|1788936_1790385_+|tRNA-4-thiouridine(8)-synthase-ThiI
MKFIIKLFPEITIKSKSVRQRFTKMLQGNIRNVLRRFDEDARVRMDWDKLVVSSRNDQFHAQYLETLACIPGIQYFLEVKLSNFTDLHDIFEQTRAVWGDRLKGKTFCVRARRVGKHDFSSLELERYVGGGLNQHCETAGVRLKKPDIQVNLEVENDELYIISAVHHGMGGFPIATQEDVLSLLSGGFDSGVASYQFIKRGCRVHYCFFNLGGAAHEIGVKQVAYYLWSKFGASHKVRFTAIDFEPVVAEILEKVDNGQMGVVLKRMMMRAAGQVADYFQIPALVTGECVGQVSSQTLTNLNVIDRVTDKVILRPLITWDKPDIISEARRIGTLEFAETMPEYCGVISKKPTIKAVLSNIEAEEANFDFAILDKVVSEARYLDIRRIGEETAAEVQEIETTEVLAADEVILDIRSADERDEKPLVVEGRDVLHIPFFKLATAFGDLPKEQTYLLYCDRGVMSKLQALYLKEKGFDNVKVYRP

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Crispr_ID: NZ_CP022186_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_5

2997230-2997353

Orphan

Consensus_repeat	Method
TGTAGGGTCGATTAGCGGAGCGTAATCGTCCGCGGCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022186_5

>merge|NZ_CP022186|5|2997230-2997353|CRISPRCasFinder
TGTAGGGTCGATTAGCGGAGCGTAATCGTCCGCGGCAACAATCCCCTCTCCCCTTGCGGGAGACAGGTAGGGTGCCAATAAGCGTGTAGGGTCGATTAGCGAAGCGTAATCGTCCGCGGCAACA

>NZ_CP022186|5|5|2997230-2997353|CRISPRCasFinder
TGTAGGGTCGATTAGCGGAGCGTAATCGTCCGCGGCAACA	ATCCCCTCTCCCCTTGCGGGAGACAGGTAGGGTGCCAATAAGCG
TGTAGGGTCGATTAGCGAAGCGTAATCGTCCGCGGCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_042467323.1\|3000880_3002257_-\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NZ_CP022186.1\|WP_034282846.1\|2994127_2994874_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270422
NZ_CP022186.1\|WP_017412250.1\|3006081_3007050_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176163
NZ_CP022186.1\|WP_005314572.1\|2996802_2997111_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_042467317.1\|3002935_3003646_+\|DUF4269-domain-containing-protein	unknown	unknown	gnl\|CDD\|379463
NZ_CP022186.1\|WP_088814123.1\|2997995_2998913_+\|IS5-like-element-ISAs4-family-transposase	unknown	unknown	gnl\|CDD\|290455
NZ_CP022186.1\|WP_017413027.1\|3004487_3004736_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|182475
NZ_CP022186.1\|WP_085941442.1\|2989280_2989655_+\|stress-response-translation-initiation-inhibitor-YciH	unknown	unknown	gnl\|CDD\|181613
NZ_CP022186.1\|WP_042467985.1\|2995092_2996106_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP022186.1\|WP_005314534.1\|3004870_3005047_+\|DUF3606-domain-containing-protein	unknown	unknown	gnl\|CDD\|371985
NZ_CP022186.1\|WP_005314532.1\|3005200_3005974_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|180440
NZ_CP022186.1\|WP_005314576.1\|2992688_2993192_+\|GDYXXLXY-domain-containing-protein	unknown	unknown	gnl\|CDD\|379571
NZ_CP022186.1\|WP_005314579.1\|2989899_2990457_+\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030
NZ_CP022186.1\|WP_005314539.1\|3002448_3002946_+\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|182734
NZ_CP022186.1\|WP_011899080.1\|2999611_3000643_-\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NZ_CP022186.1\|WP_011898588.1\|3003642_3004407_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|235420
NZ_CP022186.1\|WP_005314578.1\|2990709_2991648_+\|DUF2157-domain-containing-protein	unknown	unknown	gnl\|CDD\|378311
NZ_CP022186.1\|WP_017412979.1\|2993265_2994012_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270422
NZ_CP022186.1\|WP_005314583.1\|2988978_2989206_-\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NZ_CP022186.1\|WP_005314577.1\|2991684_2992692_+\|DUF4401-domain-containing-protein	unknown	unknown	gnl\|CDD\|379574

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_042467323.1\|3000880_3002257_-\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NZ_CP022186.1\|WP_034282846.1\|2994127_2994874_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.18127e-25
NZ_CP022186.1\|WP_017412250.1\|3006081_3007050_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176163	cd08474, PBP2_CrgA_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 5. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.14212e-100
NZ_CP022186.1\|WP_017413027.1\|3004487_3004736_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|182475	PRK10457, PRK10457, hypothetical protein; Provisional.	8.30873e-23
NZ_CP022186.1\|WP_042467317.1\|3002935_3003646_+\|DUF4269-domain-containing-protein	gnl\|CDD\|379463	pfam14091, DUF4269, Domain of unknown function (DUF4269). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved KTE sequence motif.	9.87483e-35
NZ_CP022186.1\|WP_088814123.1\|2997995_2998913_+\|IS5-like-element-ISAs4-family-transposase	gnl\|CDD\|290455	pfam13737, DDE_Tnp_1_5, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	2.37275e-48
NZ_CP022186.1\|WP_085941442.1\|2989280_2989655_+\|stress-response-translation-initiation-inhibitor-YciH	gnl\|CDD\|181613	PRK09019, PRK09019, stress response translation initiation inhibitor YciH.	4.42658e-37
NZ_CP022186.1\|WP_042467985.1\|2995092_2996106_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	6.40634e-48
NZ_CP022186.1\|WP_005314534.1\|3004870_3005047_+\|DUF3606-domain-containing-protein	gnl\|CDD\|371985	pfam12244, DUF3606, Protein of unknown function (DUF3606). This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 85 amino acids in length. There is a single completely conserved residue G that may be functionally important.	3.56969e-16
NZ_CP022186.1\|WP_005314532.1\|3005200_3005974_-\|glucose-1-dehydrogenase	gnl\|CDD\|180440	PRK06172, PRK06172, SDR family oxidoreductase.	1.9616e-83
NZ_CP022186.1\|WP_005314576.1\|2992688_2993192_+\|GDYXXLXY-domain-containing-protein	gnl\|CDD\|379571	pfam14345, GDYXXLXY, GDYXXLXY protein. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 171 and 199 amino acids in length. It contains a conserved GDYXXLXY motif.	4.47387e-37
NZ_CP022186.1\|WP_005314579.1\|2989899_2990457_+\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	2.56269e-51
NZ_CP022186.1\|WP_005314539.1\|3002448_3002946_+\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|182734	PRK10791, PRK10791, peptidylprolyl isomerase B.	2.2658e-90
NZ_CP022186.1\|WP_011899080.1\|2999611_3000643_-\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	9.20597e-16
NZ_CP022186.1\|WP_011898588.1\|3003642_3004407_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|235420	PRK05340, PRK05340, UDP-2,3-diacylglucosamine hydrolase; Provisional.	3.88382e-145
NZ_CP022186.1\|WP_005314578.1\|2990709_2991648_+\|DUF2157-domain-containing-protein	gnl\|CDD\|378311	pfam09925, DUF2157, Predicted membrane protein (DUF2157). This domain, found in various hypothetical prokaryotic proteins, has no known function.	4.01482e-24
NZ_CP022186.1\|WP_017412979.1\|2993265_2994012_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.11776e-28
NZ_CP022186.1\|WP_005314583.1\|2988978_2989206_-\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	2.19469e-16
NZ_CP022186.1\|WP_005314577.1\|2991684_2992692_+\|DUF4401-domain-containing-protein	gnl\|CDD\|379574	pfam14351, DUF4401, Domain of unknown function (DUF4401). This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with pfam09925. There is a single completely conserved residue K that may be functionally important.	2.25952e-33

>NZ_CP022186.1|WP_005314572.1|2996802_2997111_-|hypothetical-protein
MANRFVSSKNRIVQAGRWLATRGAALFAELSEFQQRIWVVSIVNDTYTDTFIVNEGSFEEPMQWMRRKQYDADMLQRVEAMQRSQVIQFELGDTRHRLMRVK
>NZ_CP022186.1|WP_042467985.1|2995092_2996106_-|GGDEF-domain-containing-protein
MDTILQALSVQVTEARDLESLTRPLLEMLETVTGLESTYLTQIDLEQSAQHILYARNSAALQIPEGGSVDWSDTLCRRALDEGRLYAADVADRWGDSAAARAMGIRTYMSSPVRTSSGSLYGTLCGASAEHKPLVTGSEHLIAFFARLIAEHVEREQLLQQLQQANNELSRQALSDPLTGLPNRRALMLELHRLFSLLKRTGHPLLISFIDLDGFKAINDTHGHDAGDLLLQTMAQQLAGALRSGDLLARVGGDEFVAVGMGPLSGEETVEAAVHCFQRRLFEQSQVQLPLASQVLNYPGASVGVVAVDPASISIDDALRQADACMYAVKRQRRAQS
>NZ_CP022186.1|WP_034282846.1|2994127_2994874_+|transporter-substrate-binding-domain-containing-protein
MKKWIGFAALLFAAITQASQELGKLHYLSEEYKPYNYTDSAGTPTGLAVELLHQVWKKTNTPPQTITIMPWARGYYLLTQKPNVVLFATARTEARDPLFKWACPIGYAEIVLIGLAKNPLTLTKLEDAQQHTIGAVRADVGEQLLLNNGFDEQKIMAANRLPQALKMLTSGRVDLISTNKTTLMDLIASQQLDPAQFKVFWMLSSEQFCFAFSHPVSDELVKEFQNGLTQVLASSEFQQIQHKYFPVP
>NZ_CP022186.1|WP_017412979.1|2993265_2994012_+|transporter-substrate-binding-domain-containing-protein
MRIRLCCCLLLMSCLGTAHAGLTKLEYLTEEYPPYNFSNEAGQPTGLAVDLLQLIWQRSGTAAQPVRILPWARGYYLLTQKPNVVLFSTARTETRSHLFKWACPIGYSEYILLAHKSKPIQLGAVEQMNDYRISAVRADAAEQLLLNRGMDETRIIPANRLSQALRMLVSGRADLLATSKLAGYDAIKALQLNADDFTVAFVLDAEELCYAFSRQVDDDLVKQFQRAMTQALASPEYQALRQRYLPVP
>NZ_CP022186.1|WP_005314576.1|2992688_2993192_+|GDYXXLXY-domain-containing-protein
MRQLALLLTGLAILAGINFTVWRYEAAMTSGEVVLLRLAPVDPRSLMQGDYMRLNYDIARQLGASRYSERTNDSDTLVIRLDEHQVANWAADGKPEQLASNERLLQVRQSDNQWLIGPDAFFFEEGTGEQFEVARYGEFRLQGDGKALLVGLRDEQFKPVGNPRARW
>NZ_CP022186.1|WP_005314577.1|2991684_2992692_+|DUF4401-domain-containing-protein
MADLTPWQRLQQADLVEGEAPRDTQPHWSSRFLLGMVGWVAALFLLFFLFMSFSQLTQDANSALMMGAVLMAIAFGLNRFAQRSDLWDQFVLALALAADAWLLYGLIDQIDLHSAPLWLGLAALSLFIAALFEHWLIRLFHSFAAAILLTLGLACLGLQLLALPLVMMTLTFCWLQAERQPAYHQLYESLTLGLALSLLVLGRLHHPLWSEGASMLDELGLSRLPLWLNPLLCAALLLGVMIRLKLPLLYGLPLVLISAFIPGMGAGALVLVLGFYAGSMGLMTLAGLLLLGFGSLYYYDLGLTLMTKSWLLLGSGALLLGARQLLHVINARRQS
>NZ_CP022186.1|WP_005314578.1|2990709_2991648_+|DUF2157-domain-containing-protein
MHFTSRQTLLDWVRRGRLAQTHLPAALALCDLPPASARWQWLFDRLLLWLGSLCLGAGLVFFVAFNWQELGRVSRLALLELPLLAMLVLLWRKPMTAPPRQALLLAMALNIGALLALVGQTYQTGADPWQLFATWALMLLPLAALGQSPLLWTTSWLLGQLALMLYWRLGLFSFFFGFDEEGLGWCLILLNAALWGALLLAPTRLKLMPAWLPGLAAGLGVTLLTLLALFDAASPWVWPAWLGWLAAAYALWHHRFIAGLAMGCLSLIAVILTALGKWMDPDVDGFLLLSLIAIGLSVAASRWLQQQRRSHA
>NZ_CP022186.1|WP_005314579.1|2989899_2990457_+|TMEM165/GDT1-family-protein
MEALLTSTLSVAIAEIGDKTQLLALLLICRFRKPWPIIAGMLAATLLNHAGAAWLGEFISRWLDPKVMTYLVAGSFIAMAAWILVPDKLDDEESPLDKYGPFMATFVLFFIAEIGDKTQIATVLLAAKYDSLTQVIAGTTLGMMLANVPVVLLGKLGADKLPLKGIRIACAILFAGLGVSTLIFA
>NZ_CP022186.1|WP_085941442.1|2989280_2989655_+|stress-response-translation-initiation-inhibitor-YciH
MSKIKLRLANSQITAMSHDNNSHLVYSTDGGMIKEQTQPQSASPFPQDGTVRIRRETKGRKGAGVITIHGVPAEQQKTIATLLKKKCGTGGGLKEGIIEIQGDKRDLIKTELEKAGFSVKLVGG
>NZ_CP022186.1|WP_005314583.1|2988978_2989206_-|ferrous-iron-transport-protein-A
MVLAQLSPGQSARIKHMNHLERTLRRKLMVMGLLPQTEVLFLRAAPLGDPLQIQCQGICLSMQKSLALQIEVELV
>NZ_CP022186.1|WP_088814123.1|2997995_2998913_+|IS5-like-element-ISAs4-family-transposase
MGKALHPITNWPQYNRSLINRGSLTFWVDAEAMDNWFHQDHHGKRGRSQLYTDQSICTFLMLKGIFSLTLRATQGLLDSLFELMNVPLCAPDYSCVSKRARTVKVAYRQPPKGRITDLVIDSTGLKVFGEGEWKVRKHGAEKRRVWRKLHLAVDPVTHDIVAAEVSLENVHDAEVLPTLLNPLRRKLGRVYADGAYDSKASHRLIARKGATACIPPRKNAGLWKKGHPRNEAVQVMSKEGLAHWKKISGYHRRSLAETAMFRFKQLMAGQITLRKYNGQVGEVMAYVSAINKLNTLGLPVRKPRV
>NZ_CP022186.1|WP_011899080.1|2999611_3000643_-|IS630-family-transposase
MPILPPLPRPQRRRIHKIIHATRDKGHARRLMAILLLHEGRTVTDVHHLTGAARSTIGRWLRWYRDEGIDALEALPAGRAPVLPIAKMVTLLVLLMQFSPQDFGYQRSRWCTELLAIKINRLTGLNVAASTLRRWLPRMGIVWRRPVPTLRIKDPAYQEKMANIDAALARCNADNPVFYEDEVDIDLNPKLGADWMFRAQQKRVVTPGQNAKHYLAGVLHAGNGRVLYVSGIKKNSSLFIAMLEKLRHHYRRAKTITLILDNYIIHKSKQTERWLKKNPKFCLVFQPVYSPWVNHIERLWHKLHETITRNHQCRGMANLLARVKYFMDTVSPFPGNGYGTAKV
>NZ_CP022186.1|WP_042467323.1|3000880_3002257_-|cysteine--tRNA-ligase
MLKIYNTLTRQKEEFKPIHPGKVGMYVCGVTIYDHCHIGHGRTFVAFDVVARYLRYCGYQLNYVRNVTDVDDKIIKRAAETNVTCDDLTERLIGDMHQDFDALGMVRPDVEPRATQHISEIIELVESLIAQDHAYVADNGDVMFIVDSYADYGKLSGQDLEQLQAGARVGVVDAKRNPLDFVLWKMSKPGEPTWESPWGPGRPGWHIECSAMNSKHLGNHFDIHGGGSDLQFPHHENEIAQSCCAHGGDYVNTWMHSGMVMVDKEKMSKSLGNFFTIRDVLAHYDAESVRYFLMSGHYRSQLNYSEDNLKQARAALERMYTALRDLPVAAAAGGDEQVARFVDAMDDDFNTPEAYSALFDLVREINRQKAEDMSVAAGLGARLRELGAVLGILQQDPDAFLKGDEADEEVAEIERLIAERNQARADKNWAAADAARARLTEMGIVLEDSAGKTCWRRA
>NZ_CP022186.1|WP_005314539.1|3002448_3002946_+|peptidyl-prolyl-cis-trans-isomerase
MVTLHTNHGDITLTLNAEKAPETVANFLQYCRDGHYDNTIFHRVIDGFMIQGGGYAPGFEEKETRAPIKNEAANGLSNKVGTVAMARTMEPHSASAQFFINVSNNDFLDFKSATTQGFGYCVFGEVTAGMDVVNKIKAVKTGNAGRMHQDVPVEDVVITKVTLAD
>NZ_CP022186.1|WP_042467317.1|3002935_3003646_+|DUF4269-domain-containing-protein
MQTDLCLLRDELTAAPAAVFPSARLTAGPNWRRLDYLARGNPRQRAAHALLNDTPLWGELQSLCLDVALVSTLAIGLDRPGSDLDILCQHSDPAALADLLAQRQWQSRALGSDIWLLEQTLIDGEGTPWPIELYVTPARVDTLNGWRHLSLMAALIEHFGHDFYQTLRTLRLQQGLKGEAAICRLLKLPGDPYQALLTLEGRDLDQLDWQPQAQAPSAQPATFSSHPVIRAPCTPS
>NZ_CP022186.1|WP_011898588.1|3003642_3004407_+|UDP-2,3-diacylglucosamine-diphosphatase
MSTLFISDIHLCSDRPDMTAALVRFLERDAPGADALYVLGDLFEFWIGDDDPNPLHHAIADAFAALRQRGVSIYFIHGNRDFLLGRQFAKRSGMTLLADPCVIDLYGERVLLSHGDLLCTLDLGYQKLRRITQLKWLRWLFLRLPLTRRLAIACKMRGQSQMENVQKSQTIMDVTPAAVDALLRQHGCQLLIHGHTHRPAIHDFTLDGQPARRIVLGDWFEQGSVLVCSPGEQRLEQRTLPSLNPAGAHESDNL
>NZ_CP022186.1|WP_017413027.1|3004487_3004736_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGFITWIVLGLLVGILAKWIMPGRDGGGFFMTVLLGIIGAMVGGYVGTLLGLGSVTGFNLSSIAIATMGALIVLFVFNKIRS
>NZ_CP022186.1|WP_005314534.1|3004870_3005047_+|DUF3606-domain-containing-protein
MPDNNTLAHPLDAKSINVNDPYEMKLWIKTFECTEVQLKRAVKAVGTSGKAIRKHLKK
>NZ_CP022186.1|WP_005314532.1|3005200_3005974_-|glucose-1-dehydrogenase
MIQSLRLQDSVALVTGGGSGIGRAAALAFVRDGAKVVVAGRRELELLETVDLIRAQGGEALAVPTDVTDSAQVKALIAVTLAHFGRLDAAFNNAGVEGVAPISEMTEVEFDRVIATNLKGVWLSVKYELEAMTAAGCGGAIVNTSSWLTQGASVGSAAYSASKGGLDAMIRALALEAGPHGIRINNVNPGIINTPMAQRMGANEETLKPFVRLTPAGRIGGADDVGDVVAWLCSDEARFITGQSLLVDGGFTIAGLR
>NZ_CP022186.1|WP_017412250.1|3006081_3007050_+|LysR-family-transcriptional-regulator
MGNAVRTNEFGELTAFVAVAEEKSFRKAAARLNLTASTLSHALRALEERLGVRLLNRTTRTVSPTQAGLALLAEIAPAFNVIAHAVEKVNAFRESPQGRVRINTPRIAADMIFLPQLQKFCHQYPDVQLELATNDGFVDIISQGFDAGVRIRSDVQQDMSAVRLTADFHSAVYGSPAYFERHAIPLTPADLQHHLCIGRREITGGSLYRWEFEKDGRQIAVPVSGPVTVDNVSMMTRLALDGIGLVYTAQSPEHDDLVTTGRLIRVLADWSITYPGFFLYYPGHRQLPAALKAVIDCFRLPFLSGTETTSYDTVQISCASVP

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Crispr_ID: NZ_CP022186_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_6

3530780-3530924

Orphan

Consensus_repeat	Method
GCCCTGGGCACACCGGCCTTGATATTCTTCTGTTTCAGTTCCCAGGCATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022186_6

>merge|NZ_CP022186|6|3530780-3530924|CRISPRCasFinder
GCCCTGGGCACACCGGCCTTGATATTCTTCTGTTTCAGTTCCCAGGCATCCTTAATGTGAAGAGGCTGGGGCTTGCATCCAAGTCGGTCCGTTGCGCCCTGGGCACACCGGCCTTGATATTCTTCTGTTTCAGTTCCCAGGCATC

>NZ_CP022186|6|6|3530780-3530924|CRISPRCasFinder
GCCCTGGGCACACCGGCCTTGATATTCTTCTGTTTCAGTTCCCAGGCATC	CTTAATGTGAAGAGGCTGGGGCTTGCATCCAAGTCGGTCCGTTGC
GCCCTGGGCACACCGGCCTTGATATTCTTCTGTTTCAGTTCCCAGGCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_011899080.1\|3525397_3526429_+\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NZ_CP022186.1\|WP_005316974.1\|3522126_3523077_+\|transaldolase	unknown	unknown	gnl\|CDD\|235381
NZ_CP022186.1\|WP_005317016.1\|3535652_3536237_+\|outer-membrane-lipoprotein-LolB	unknown	unknown	gnl\|CDD\|319984
NZ_CP022186.1\|WP_005316972.1\|3519941_3521384_-\|alanine:cation-symporter-family-protein	unknown	unknown	gnl\|CDD\|376500
NZ_CP022186.1\|WP_042468530.1\|3529868_3530723_-\|3-deoxy-8-phosphooctulonate-synthase	unknown	unknown	gnl\|CDD\|235363
NZ_CP022186.1\|WP_042468523.1\|3540743_3541385_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP022186.1\|WP_076611341.1\|3527709_3528627_+\|IS5-like-element-ISAs4-family-transposase	unknown	unknown	gnl\|CDD\|290455
NZ_CP022186.1\|WP_042468524.1\|3538546_3540535_+\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|277354
NZ_CP022186.1\|WP_005317007.1\|3532214_3533084_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NZ_CP022186.1\|WP_042468528.1\|3530974_3531775_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225464
NZ_CP022186.1\|WP_017412585.1\|3536263_3537133_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	unknown	unknown	gnl\|CDD\|234731
NZ_CP022186.1\|WP_005317010.1\|3533133_3534222_-\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NZ_CP022186.1\|WP_005317005.1\|3531786_3532170_-\|SirB2-family-protein	unknown	unknown	gnl\|CDD\|377264
NZ_CP022186.1\|WP_005316978.1\|3523467_3524016_-\|hemerythrin	unknown	unknown	gnl\|CDD\|226454
NZ_CP022186.1\|WP_005316980.1\|3524262_3524931_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP022186.1\|WP_005316999.1\|3526723_3527104_+\|autonomous-glycyl-radical-cofactor-GrcA	unknown	unknown	gnl\|CDD\|213978
NZ_CP022186.1\|WP_042468526.1\|3534275_3535532_-\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NZ_CP022186.1\|WP_005316976.1\|3523236_3523419_+\|DUF3545-family-protein	unknown	unknown	gnl\|CDD\|371878
NZ_CP022186.1\|WP_005316983.1\|3524962_3525220_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005317019.1\|3537497_3538445_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_011899080.1\|3525397_3526429_+\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	9.20597e-16
NZ_CP022186.1\|WP_005316974.1\|3522126_3523077_+\|transaldolase	gnl\|CDD\|235381	PRK05269, PRK05269, transaldolase B; Provisional.	0
NZ_CP022186.1\|WP_005317016.1\|3535652_3536237_+\|outer-membrane-lipoprotein-LolB	gnl\|CDD\|319984	cd16326, LolB, LolB, an outer membrane lipoprotein receptor. This family contains the outer membrane lipoprotein receptor, LolB, which catalyzes the last step of lipoprotein transfer from the inner to the outer membrane. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA transports lipoproteins through the periplasm to LolB, which then localizes them to outer membranes; the protruding loop of LolB has been shown to be essential for the localization of lipoproteins in the anchoring of bacterial triacylated proteins to the outer membrane.	6.33028e-56
NZ_CP022186.1\|WP_005316972.1\|3519941_3521384_-\|alanine:cation-symporter-family-protein	gnl\|CDD\|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_CP022186.1\|WP_042468530.1\|3529868_3530723_-\|3-deoxy-8-phosphooctulonate-synthase	gnl\|CDD\|235363	PRK05198, PRK05198, 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional.	0
NZ_CP022186.1\|WP_042468523.1\|3540743_3541385_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	3.89654e-107
NZ_CP022186.1\|WP_076611341.1\|3527709_3528627_+\|IS5-like-element-ISAs4-family-transposase	gnl\|CDD\|290455	pfam13737, DDE_Tnp_1_5, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	2.87975e-48
NZ_CP022186.1\|WP_042468524.1\|3538546_3540535_+\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|277354	cd07409, MPP_CD73_N, CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain. CD73 is a mammalian ecto-5'-nucleotidase expressed in endothelial cells and lymphocytes that catalyzes the conversion of 5'-AMP to adenosine in the final step of a pathway that generates adenosine from ATP. This pathway also includes a CD39 nucleoside triphosphate dephosphorylase that mediates the dephosphorylation of ATP to ADP and then to 5'-AMP. These enzymes all have an N-terminal metallophosphatase domain and a C-terminal 5'nucleotidase domain. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.73753e-78
NZ_CP022186.1\|WP_005317007.1\|3532214_3533084_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	9.92111e-127
NZ_CP022186.1\|WP_042468528.1\|3530974_3531775_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|225464	COG2912, COG2912, Uncharacterized conserved protein [Function unknown].	3.14853e-57
NZ_CP022186.1\|WP_017412585.1\|3536263_3537133_+\|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	gnl\|CDD\|234731	PRK00343, ipk, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional.	0
NZ_CP022186.1\|WP_005317010.1\|3533133_3534222_-\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NZ_CP022186.1\|WP_005317005.1\|3531786_3532170_-\|SirB2-family-protein	gnl\|CDD\|377264	pfam04247, SirB, Invasion gene expression up-regulator, SirB. SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown.	3.44023e-23
NZ_CP022186.1\|WP_005316978.1\|3523467_3524016_-\|hemerythrin	gnl\|CDD\|226454	COG3945, COG3945, Uncharacterized conserved protein [Function unknown].	3.25318e-17
NZ_CP022186.1\|WP_005316980.1\|3524262_3524931_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	5.99938e-147
NZ_CP022186.1\|WP_005316999.1\|3526723_3527104_+\|autonomous-glycyl-radical-cofactor-GrcA	gnl\|CDD\|213978	TIGR04365, Autonomous_glycyl_radical_cofactor, autonomous glycyl radical cofactor GrcA. This small protein, previously designated YfiD in E. coli, is closely homologous to pyruvate formate_lyase (PFL) in a region surrounding the stable glycyl radical that is prepared by the action of pyruvate formate-lyase activase, a radical SAM enzyme. When damage at the site of this radical breaks the main chain of PFL, this protein acts as a spare part that reintroduces the needed stable glycyl radical. Cutoffs for this model are set to exclude a set of closely related phage proteins that appear to have a corresponding function.	2.14422e-82
NZ_CP022186.1\|WP_042468526.1\|3534275_3535532_-\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	0
NZ_CP022186.1\|WP_005316976.1\|3523236_3523419_+\|DUF3545-family-protein	gnl\|CDD\|371878	pfam12065, DUF3545, Protein of unknown function (DUF3545). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 60 to 77 amino acids in length. This protein has two completely conserved residues (R and L) that may be functionally important.	3.33253e-11
NZ_CP022186.1\|WP_005317019.1\|3537497_3538445_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0

>NZ_CP022186.1|WP_042468530.1|3529868_3530723_-|3-deoxy-8-phosphooctulonate-synthase
MEQKNIKINDIDVANDKPLVLFGGMNVLESRDMAMAVCEKYVEVTSKLGIPFVFKASWDKANRSSIHSYRGPGLEEGMKIFQELKATFGMPVISDLHEVHQAKPVAEVVDVIQLPAFLARQTDLVEAMARTGNVINIKKPQFLSPSQMKNITDKFEECGNDQLILCERGANFGYDNLVVDMLGLGVMKKSTGGYPVIFDVTHSLQCRDPLGAASGGRRDQVTELARAGMAVGLAGLFIESHPDPKVARCDGPSALPLDKLEGFLKQMKAIDDLIKGFEPLDTSA
>NZ_CP022186.1|WP_076611341.1|3527709_3528627_+|IS5-like-element-ISAs4-family-transposase
MGKALHPITNWPQYNRSLINRGSLTFWVDAEAMDNWFHQDHHGKRGRSQLYTDQSICTFLMLKGIFSLTLRATQGLLDSLFELMNVPLCAPDYSCVSKRARTVKVAYRQPPKGRITDLVIDSTGLKVFGEGEWKVRKHGAEKRRVWRKLHLAVDPVTHDIVAAEVSLENVHDAEVLPTLLNPLRRKLGRVYADGAYDSKASHRLIARKGATACIPPRKNAGLWKKGHPRNEAVQVMRKEGLAHWKKISGYHRRSLAETAMFRFKQLMAGQITLRKYNGQVGEVMAYVSAINKLNTLGLPVRKPRV
>NZ_CP022186.1|WP_005316999.1|3526723_3527104_+|autonomous-glycyl-radical-cofactor-GrcA
MIKGIQITQSANTALLNSFWLLDEEKQQARCICAKGDTFAADQEVKLSDLGQFEYRELPVQAEPAVEGGQHLNVNVLRRETLEDAIANPEKYPQLTIRVSGYAVRFNALTPEQQRDVVTRTFTQSL
>NZ_CP022186.1|WP_011899080.1|3525397_3526429_+|IS630-family-transposase
MPILPPLPRPQRRRIHKIIHATRDKGHARRLMAILLLHEGRTVTDVHHLTGAARSTIGRWLRWYRDEGIDALEALPAGRAPVLPIAKMVTLLVLLMQFSPQDFGYQRSRWCTELLAIKINRLTGLNVAASTLRRWLPRMGIVWRRPVPTLRIKDPAYQEKMANIDAALARCNADNPVFYEDEVDIDLNPKLGADWMFRAQQKRVVTPGQNAKHYLAGVLHAGNGRVLYVSGIKKNSSLFIAMLEKLRHHYRRAKTITLILDNYIIHKSKQTERWLKKNPKFCLVFQPVYSPWVNHIERLWHKLHETITRNHQCRGMANLLARVKYFMDTVSPFPGNGYGTAKV
>NZ_CP022186.1|WP_005316983.1|3524962_3525220_-|hypothetical-protein
MLWFIGSMGQGAMALEMGPVAIDLLFYIEGLYSPLGGSVTECGRWPAIPGAGDAPCCVLSLKDTALLGGLRRWRYGCVLLSGPLS
>NZ_CP022186.1|WP_005316980.1|3524262_3524931_-|uracil-DNA-glycosylase
MRTWTDVIGSEKEQDYFKATLATVRSEREAGKVIYPPATEVFNAFKLTELDQVKVVILGQDPYHGPNQAHGLCFSVLPGVRTPPSLVNIYKEMQRDLPDFVTPNHGFLESWAQQGVLLLNTVLTVQAGMAHSHAHLGWETFTDRVIEQINASCQGVVFLLWGAHAQKKGRFIDRSRHHVLSAPHPSPLSAHRGFIGCGHFSETNRLLSQQGMSPINWHSVCG
>NZ_CP022186.1|WP_005316978.1|3523467_3524016_-|hemerythrin
MLSSLHKDHLNIARLLTLLKHKLVAIRNEQPVSYFLIRDAVDYLREVSDKYHHPKEDMIYDYYLKYRVVEGEVANRLQEEHARLLGAGAELKEMVEMILMDSVIPLDQFTARLEQFVALQEAHMNYEEAVIFPHLRDSLTEDDWRHLEQLWQNRAIGDPLFGAEISQHFQELAQRLSLPPSS
>NZ_CP022186.1|WP_005316976.1|3523236_3523419_+|DUF3545-family-protein
MEMFNFDYDDVVELGSRSRGTTGKKRKWREIEALKDKHRLQKELQSIDIAYEGLSDEIEL
>NZ_CP022186.1|WP_005316974.1|3522126_3523077_+|transaldolase
MADKLTQLKALTTVVADTGDIEAIKRYQPIDATTNPSLVLKASEIPEYAALIEDAISWAKSQSQDKAQQIIDAGDKLAVNIGLEVLKIVPGRISTEVDARLSFDTEASIAKARKLIRLYNEAGIANDRILIKLASTWEGIRAAEVLEKEGIQCNLTLLFSFAQARACAEAGAFLISPFVGRILDWYKAKHNRDYTPSEDPGVVSVTAIYDYYKQHDYPTVVMGASFRNTGEILELAGCDRLTIGPALLEELSKTEGAVVRKLNYTGERKAKPTPMSEAEFRWELNQDAMAHEKLGEGIRMFAVDQGKLETMLASRL
>NZ_CP022186.1|WP_005316972.1|3519941_3521384_-|alanine:cation-symporter-family-protein
MDTLIAMLNDLMWGAVLIYLLIGVGIFFTFRLGFIQVRHFGHMFSVLRNSRKSDKAGISSFQALCTSLAARVGTGNLAGVAVAIYLGGPGAIFWMWLIAFIGMATAFVESTLAQLYKVKDEDGNYRGGPAYYMERGLGMRWMGVVFSLCLLLAFGLVFNAVQANSISLAMKVAFGIPDWATGLALVVLSGLIIFGGIRGIARFAELVVPFMALAYILMALFVVAMNITELPGVFALIIKSAFGIEQAGSGAMGYAISQAMINGIKRGLFSNEAGMGSAPNAAATATPYPPHPASQGYVQMLGVFLDTIVICTCTAAIILMSGQFEPGSGITGVELTQRALSSQIGGGGNIFIAAAIFFFAFTSIVANYSYAETNLVFLEHNHKGGLMLFRMFVLGMVMFGSVGELPTVWAMADVSMGLMAIVNLVAILLLSSVAIKLAKDYNDQLKLGKVPTFDANKYPEIRSQLEEGIWDNPTQHGKQL
>NZ_CP022186.1|WP_042468528.1|3530974_3531775_-|tetratricopeptide-repeat-protein
MIRVDEWTDFEAHDIAELALSVSDEIHGISGRGEAELARLDAWLDEAIAEGSCDEVRRQLLQGFYQTLSFHGDWQDYFSAANSDLAQVLATKRGIPVSLGILIIQLGRKLGLDVEGICFPGHFLVSFAGSEGEVYVDPFTGDELSLHHMELLLRGALGNLATLTPEHLQPSGQWEIIERLLNVSKGALLREDRMTEALRCSELLLRMKPGDPLETRDRGFIYEQLDCPRFAADDFEYFIEQCPDDPVADVLKVQLAALDLSPKPLH
>NZ_CP022186.1|WP_005317005.1|3531786_3532170_-|SirB2-family-protein
MYFALKHLHLVLIASAVLMFMLRFYWVQTGSGRAYSDQIMKVSGWLNGLVVLSGVLLCMVLDLNPLNNGTPWLSEKLTAILVVAFLAMMALRLACNNGIRWFAFLGAIGWVFFIAKLAVYKQASLFG
>NZ_CP022186.1|WP_005317007.1|3532214_3533084_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MQIQQARAHIMATLAGGESPRADADVLLCHLLDCRRSYLMTWPERELDAAQQDRLQGWLTRRLAGEPIAHLVGEREFWSLPLKVSPATLIPRPDTEVLVEQALARLPPKPASPDQAPCALLDLGTGTGAIALALKSERPDADVWAVDRMPEAAALARDNSAALGLPITVRDGSWFEPLCDPLLSQAPRFAMIVSNPPYIDGADPHLNKGDVRFEPRSALVADEQGLADIRLIVAGAPAHLCPGGWLLLEHGWQQGEAVRQLLLQQGFSRVETVRDYGDNERVTLGCLAH
>NZ_CP022186.1|WP_005317010.1|3533133_3534222_-|peptide-chain-release-factor-1
MNPSLIRKLEGLIERHEEVQAMLGEPGVASDQDRYRALTREYAQLEDIVHAFQRFRQAEENLEATKLMLEEDDADLREMAQEELPLAKSTLEEQEQALQVMLLPRDPKDDNNCYLEIRAGAGGDEAAIFAGDLFRMYSRYAERQGWRISIVSCNDGEHGGYKEVIAKVDGEHVYGRLKFESGGHRVQRVPETESQGRVHTSACTVAVLPEVPEAEQIEINANDLKIDTFRASGAGGQHVNKTDSAIRITHLPTGLVVECQDERSQHKNRAKAMSVLSARLQAAEDERHRAAEQSTRRNLVGSGDRSERIRTYNYPQGRLSEHRINLTLYRLGEIMEGDLDCIISPMIQEYQADQLASLAENS
>NZ_CP022186.1|WP_042468526.1|3534275_3535532_-|glutamyl-tRNA-reductase
MSLLALGINHNTASVALRERVAFGPDCIDRALRELVTQPGVSEAVIVSTCNRTELYCSLEKGQGEQVLHWLQRFHGLDAAEVVSAIYQHQDEEAVRHLMRVACGLDSLVLGEPQILGQIKQSYAHAQQSEAVKGSLERLFQKSFSVAKRVRTDTEIGASAVSVAFAAVSLGRRIFSDLSQTKVLLVGAGETIELVARHLREQNVTCMMVANRTLQRAQLLAEEFGAQVMTLEEIPDYLHEADIVISSTASPLPIIGKGMVERALKARRFKPMFLVDIAVPRDIEAEVDELSDAYLYTVDDLQGIIEQNLETRKRAAAEAEIIVLEERDEFMGWYRSQHSVDLIRDYRHQAQQVADEELQRALLSLQQGENAEQALKAMAHRLTNKLIHAPTQALRQAAAQGDHHQLSRLRQVLGLPQE
>NZ_CP022186.1|WP_005317016.1|3535652_3536237_+|outer-membrane-lipoprotein-LolB
MTLFLRIFTFGCLLLLAGCTTTQPQRDQVNWQKERTRLEQLSHWQLSGKMAIITVQQKGSARVNWQQNGDDYRLNLTSLIGTHILELSRSNGEITLIDNEGNPHQSQDAEALIYQLTGWNIPVQGLPEWIKGLPGKAEFELNPDSSLASVRDGQWQIVYGDYRDQDGYRLPHLLTMTGQGSRLKLQINQWTLAR
>NZ_CP022186.1|WP_017412585.1|3536263_3537133_+|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase
MATIRWPAPAKLNLFLNVNGRRPDGYHELQTLFIFLDHGDWLEFEPLPDTDQLTLSPAIPGVPDEQNLIIRAARLLQARLPSPQGAHIRLEKLLPMGGGIGGGSSDAATTLVALNHLWQAGLGEDELAELGVQLGADVPVFVRGRAAFAEGVGERLQPVELPGAWYLVLKPDCHVATAAVFQDPDLPRATPKMAFHNLLEGEWKNDCELLVKKRYPEVANALGWLLEYAPSRMTGTGACVFAQFEDEKAAREVLAKVPKRWDGFVAKGENISPLFVTLQQISDWGIAKR
>NZ_CP022186.1|WP_005317019.1|3537497_3538445_+|ribose-phosphate-pyrophosphokinase
MPDMKLFAGNATPELAQKIADRLFIKLGNAAVGRFSDGEISVQINENVRGGDIFIIQSTCAPTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPVLLEDMKSKNLESPVVVSPDIGGVVRARAIAKLLDDTDIAIIDKRRPRPNVSQVMHLIGDVAGRDCIIVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPVFSGSAVENIKNSVIDELIITDSIPLTAEMKAVDKVKQLTLSTVLAEAIRRISNEESISAMFEH
>NZ_CP022186.1|WP_042468524.1|3538546_3540535_+|bifunctional-metallophosphatase/5'-nucleotidase
MNRLRPLLLLACCSFLFACQPGKENQPFALTLAHMNDTHSQFDPVNAELKGPIFGKQGETDTLYTRFGGYPRLLTMVKSYQAEALAKNQPLLLLHGGDAWQGSGYFKLNEGMANSELLSQFGLDAMALGNHEFDLDNQKLARFIEGVNFPLLAANLDTRDDPALRHATNLKPFVVYAFDGNQKSPVTDLNKLPQGKQLVAVMGLVLEDMANISPNVGKLRFGKEVESAQSTVDMLRKKGIHHVIALTHIGNERDLALASRVNGIDAIVGGHSHSLLGDFTNIGWGKTGEYAQLVTNPDGVGLTCVVQAGSYAQAIGLAWVSFDGQGRVIGCKGQNKLLASRDFFADPARQQALDKASGKQASKFVDAQPNLVTVDEDPRLRGIIDSHYKPALEQAFGPVIATVPAPLQNARRPGDNGSDSHGSDVAPLVAEGQYYWANTQAVQALTGGPVHFALLAVGGVRADLPAGELREGDTALTLLPFKNQLSVLTLSGADVRALLAETITATLPASAHAGKFPYGGHLRYTFTETEAGKRGDLTQLQWQTTEGQWQDLVDNQRYRVVMNAYSANGNDGWQALARAQSLRAERLDLAWVDGKLTGFPVEKVEQNGDQLNARYARGQTLDCQARVVNCGTDAASFVQYVREQRPTLTALSEPTVTLLRAE
>NZ_CP022186.1|WP_042468523.1|3540743_3541385_+|aminoacyl-tRNA-hydrolase
MTNQIKLIVGLGNPGPEYAKTRHNAGAWYVEQLARWHNVSLREEPKFFGHTARIQVEGQDVRLLIPNTYMNLSGKAVAALARFYQIEPEAMLVAHDELDLPPGIAKFKQGGGHGGHNGLKDIIARMGNNNNFFRLRLGIGHPGAKELVAGFVLTKAPSSEQNLIDAALDESLRATDILFKQDMTKAMNRLHSFKAGKYITGCACVPHSIYQVR

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Crispr_ID: NZ_CP022186_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_7

4187276-4187375

Unclear

Consensus_repeat	Method
TGCCTGCGCCGATAAAGGCGAGG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP022186_7

>merge|NZ_CP022186|7|4187276-4187375|CRISPRCasFinder
TGCCTGCGCCGATAAAGGCGAGGATTCTCTGCTGCATCAAACACTCCTGTGGATGAAATGGCTGCAAACACCTGCGCTGCCTGCGCCGATAAAGGCGAGG

>NZ_CP022186|7|7|4187276-4187375|CRISPRCasFinder
TGCCTGCGCCGATAAAGGCGAGG	ATTCTCTGCTGCATCAAACACTCCTGTGGATGAAATGGCTGCAAACACCTGCGC
TGCCTGCGCCGATAAAGGCGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005320452.1\|4195188_4195650_-\|chemotaxis-protein-CheX	unknown	unknown	gnl\|CDD\|381734
NZ_CP022186.1\|WP_011899099.1\|4184802_4185102_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005320467.1\|4187402_4188104_-\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|143497
NZ_CP022186.1\|WP_005320494.1\|4180769_4181198_-\|DUF2753-family-protein	unknown	unknown	gnl\|CDD\|287867
NZ_CP022186.1\|WP_005320465.1\|4189213_4190323_+\|PilT/PilU-family-type-4a-pilus-ATPase	unknown	unknown	gnl\|CDD\|227341
NZ_CP022186.1\|WP_011899101.1\|4193570_4194878_+\|branched-chain-amino-acid-transport-system-II-carrier-protein	unknown	unknown	gnl\|CDD\|283235
NZ_CP022186.1\|WP_085941509.1\|4194953_4195217_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_017412061.1\|4192668_4193379_+\|methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP022186.1\|WP_005320462.1\|4191316_4192540_-\|ATP-dependent-RNA-helicase-SrmB	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236877
NZ_CP022186.1\|WP_005320477.1\|4185907_4186459_-\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NZ_CP022186.1\|WP_005320464.1\|4190354_4191128_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_CP022186.1\|WP_005320451.1\|4195639_4196098_-\|zinc-uptake-transcriptional-repressor-Zur	unknown	unknown	gnl\|CDD\|183251
NZ_CP022186.1\|WP_085941508.1\|4179986_4180766_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235852
NZ_CP022186.1\|WP_005320492.1\|4181503_4182166_+\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NZ_CP022186.1\|WP_005320497.1\|4179486_4179927_-\|copper-chaperone-PCu(A)C	unknown	unknown	gnl\|CDD\|377298
NZ_CP022186.1\|WP_005320482.1\|4185170_4185590_-\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NZ_CP022186.1\|WP_005320466.1\|4188143_4189178_+\|type-IV-pilus-twitching-motility-protein-PilT	unknown	unknown	gnl\|CDD\|225364
NZ_CP022186.1\|WP_011899098.1\|4183088_4184693_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|185059
NZ_CP022186.1\|WP_005320479.1\|4185608_4185908_-\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP022186.1\|WP_005320489.1\|4182213_4182921_-\|chromosome-partitioning-protein-ParB	unknown	unknown	gnl\|CDD\|378068

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_005320452.1\|4195188_4195650_-\|chemotaxis-protein-CheX	gnl\|CDD\|381734	cd17906, CheX, chemotaxis phosphatase CheX. This family contains CheX CheY-P phosphatase which is very closely related to CheC chemotaxis phosphatase; both dephosphorylate CheY, although CheC requires binding of CheD to achieve the level of activity of CheX. CheX has been shown to be the most powerful CheY-P phosphatase of the CheC-FliY-CheX (CXY) family. Structural and functional data of CheX and its CheY3 substrate in Borrelia burgdorferi (the causative agent of Lyme disease) bound to the phosphoryl analog BeF3(-) and Mg2+ reveal a unique mode of binding, but a catalytic mechanism which is virtually identical to that used by the structurally unrelated CheZ, providing a striking example of convergent evolution. Thus, CheX is quite divergent from the rest of the CXY family; it forms a dimer and some may function outside chemotaxis. The data also suggest a possible CheX regulatory mechanism through dissociation of the CheX homodimer.	2.53743e-52
NZ_CP022186.1\|WP_005320465.1\|4189213_4190323_+\|PilT/PilU-family-type-4a-pilus-ATPase	gnl\|CDD\|227341	COG5008, PilU, Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_CP022186.1\|WP_005320467.1\|4187402_4188104_-\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|143497	cd06824, PLPDE_III_Yggs_like, Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins. This subfamily contains mainly uncharacterized proteobacterial proteins with similarity to the hypothetical Escherichia coli protein YggS, a homolog of yeast YBL036c, which is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene. Like yeast YBL036c, Yggs is a single domain monomeric protein with a typical TIM-barrel fold. Its structure, which shows a covalently-bound PLP cofactor, is similar to the N-terminal domain of the fold type III PLP-dependent enzymes, bacterial alanine racemase and eukaryotic ornithine decarboxylase, which are two-domain dimeric proteins. YggS has not been characterized extensively and its biological function is still unkonwn.	4.9929e-133
NZ_CP022186.1\|WP_005320494.1\|4180769_4181198_-\|DUF2753-family-protein	gnl\|CDD\|287867	pfam10952, DUF2753, Protein of unknown function (DUF2753). This bacterial family of proteins has no known function.	8.70931e-75
NZ_CP022186.1\|WP_005320462.1\|4191316_4192540_-\|ATP-dependent-RNA-helicase-SrmB	gnl\|CDD\|236877	PRK11192, PRK11192, ATP-dependent RNA helicase SrmB; Provisional.	0
NZ_CP022186.1\|WP_011899101.1\|4193570_4194878_+\|branched-chain-amino-acid-transport-system-II-carrier-protein	gnl\|CDD\|283235	pfam05525, Branch_AA_trans, Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.	2.17155e-144
NZ_CP022186.1\|WP_005320451.1\|4195639_4196098_-\|zinc-uptake-transcriptional-repressor-Zur	gnl\|CDD\|183251	PRK11639, PRK11639, zinc uptake transcriptional repressor Zur.	2.04149e-52
NZ_CP022186.1\|WP_017412061.1\|4192668_4193379_+\|methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	5.11955e-75
NZ_CP022186.1\|WP_005320477.1\|4185907_4186459_-\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	2.32154e-12
NZ_CP022186.1\|WP_005320464.1\|4190354_4191128_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	1.02245e-150
NZ_CP022186.1\|WP_085941508.1\|4179986_4180766_+\|enoyl-CoA-hydratase	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	7.64876e-86
NZ_CP022186.1\|WP_005320492.1\|4181503_4182166_+\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	3.73127e-64
NZ_CP022186.1\|WP_005320497.1\|4179486_4179927_-\|copper-chaperone-PCu(A)C	gnl\|CDD\|377298	pfam04314, PCuAC, Copper chaperone PCu(A)C. PCu(A)C is a periplasmic copper chaperone. Its role may be to capture and transfer copper to two other copper chaperones, PrrC and Cox11, which in turn deliver Cu(I) to cytochrome c oxidase.	6.17212e-42
NZ_CP022186.1\|WP_005320482.1\|4185170_4185590_-\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	4.01045e-58
NZ_CP022186.1\|WP_005320466.1\|4188143_4189178_+\|type-IV-pilus-twitching-motility-protein-PilT	gnl\|CDD\|225364	COG2805, PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion].	0
NZ_CP022186.1\|WP_011899098.1\|4183088_4184693_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|185059	PRK15104, PRK15104, oligopeptide ABC transporter substrate-binding protein OppA; Provisional.	0
NZ_CP022186.1\|WP_005320479.1\|4185608_4185908_-\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	7.2285e-55
NZ_CP022186.1\|WP_005320489.1\|4182213_4182921_-\|chromosome-partitioning-protein-ParB	gnl\|CDD\|378068	pfam08857, ParBc_2, Putative ParB-like nuclease. This domain is probably distantly related to pfam02195. Suggesting these uncharacterized proteins have a nuclease function.	1.22063e-70

>NZ_CP022186.1|WP_005320477.1|4185907_4186459_-|YggT-family-protein
MNTAYFLINTIFDIYLMVVLLRVWLQWARADFYNPMSQMVVKVTNPLVIPLRRVIPGFGGVDMASVLLAIIIAFAKLALLKSMNVLLADWLTISLFAALTVLKKAGSMIFWVLLIRAILSWVSQGRNPIEHVMHQLTEPFLAPIRRILPALGGLDLSVLVAFIGLQAINYLLGDLFGQLWWMI
>NZ_CP022186.1|WP_005320479.1|4185608_4185908_-|YggU-family-protein
MPAVLREGDELILHLMIQPKASRDQIVGLHGDELKVAITAPPVDGQANSHLIKYLAKQFKVAKGQVRIVRGELGRHKTVAIESPRQIPAEIHALLETQG
>NZ_CP022186.1|WP_005320482.1|4185170_4185590_-|DUF4426-domain-containing-protein
MKTAWISCLLALLMTLPLRAEQMKELGPWQVHYSAFNSSFLTPDVAKAYGLERSRYNGIINIAVQNKQGVAQAVGITGEAKNLTGTLRTLTFQEVKEGDAIYYLAVLPYRNQDTYQFTLKIMGEGQQQTLTFQQTFYVD
>NZ_CP022186.1|WP_011899099.1|4184802_4185102_+|hypothetical-protein
MRFLLMIPLLVTLPAHAASESQCRQAFTDWMLTQHQQFSDRNASKMKRRLAERAIDQMRDEFAKQESFCQAMEWATHHQDQDPRFNPRPGEIHDFTPAS
>NZ_CP022186.1|WP_011899098.1|4183088_4184693_+|peptide-ABC-transporter-substrate-binding-protein
MKGWSPLLALLGCACVQAADVPPRTQLAAEQAVVRHLKDEPASLSPLKLVGLPELQVLRDLYEGLLTQGPDGKVLPGVATRWDNKDNQQFTFHLRPDARWSNGDKVKAADFVYGWRKLVDPKEAATFAWFAQLAHFTKVDEIVAGKLPPEALGVKALDEHTLQVTLSQPVPYFLSLLTHPSLSPLHQASMEQYGNQWTQPGKLVGNGAFVLSQRVVNEKLELAPNPHYWDRAHTVLTKVTFVPINQETAATNRYLAGDLHITESFPKEQYHKLMQQIPGEVHTPDQLGTYYYAFNTQLPPLNDVRVRKALSYTIDRGLIAAKVLGTGEKPAYRFTPDVTADFEPKANLLSSTSQQDLDARARVLLQEAGYGPAKPLKLTLLYNTAEIHKKMALAIANLWKQKLGAQVELTNQEWKTYLDSRQSGQFEVIRSSWVADYNDPSAFLGLWGSRHSGNMARFANARYDEILTQAAKSRDPGERARLFDEAESILQDEAPIAPIYQYTNARLIKPWLKGYPINNPEDVAYSRQLYLIKH
>NZ_CP022186.1|WP_005320489.1|4182213_4182921_-|chromosome-partitioning-protein-ParB
MRAWILLALAISQGAWALAPCERETQVGSWCEVNIDQLHPTQGGVGQIQVDNTQAELAGKSEKQLDKVMKKKEIPIVIAPDGGYWLVDRHHLTKALWQLGVKQARVKVIARLQDKSSFWSQMQGNHWAWLKDEKGAPLTPEQLPVHIGDLPDYPYRTVAGMLQDAGYFEKRDQVYFVEFAWASWLGQQLNWLPVDGASLMERLNQAKRLACSSKASDLPGYPGKQCRVNQSRSGS
>NZ_CP022186.1|WP_005320492.1|4181503_4182166_+|CatB-related-O-acetyltransferase
MKHCQHWSQVEYLHLTVTNPNISLKGQHSYYSGAWDGPFEEEAVRYLHGDSWSRSPDTGWEPLWHIDRLHIGDYVQIAAGVKIIMGGNHTHNPAFISTYPFADPDALKRSYRPAGDTRIGNDVWIGMDAMIMPGVTIGDGAIIAARSLVTQDVPPYCMVAGAPARVIRQRFAVQETTRLQALAWWDWPDEQVQALLPLIQQGEVALLEQAAARWHSAEQE
>NZ_CP022186.1|WP_005320494.1|4180769_4181198_-|DUF2753-family-protein
MTHHIWQRYMLEAENALGAGALGAAICLYQQALAEVYELASDDLDELASMRVATCHRLADFWRAMEEPAYELRYLKLASELVTALVPQCPNRECESLVSELGCCQAALISFLKRHPNPEIARLIQLQDKVQGCELIGRFRLN
>NZ_CP022186.1|WP_085941508.1|4179986_4180766_+|enoyl-CoA-hydratase
MAACDNKDLDMDPIIVAEQQDGLLTLTFNRPDKRNALNTDMYRALTQALRQATQDDAVHALLIQGQSDCFTAGNDLADFMGKSSLDADDPILQFLHTLADFPKPVIAAVGGPAVGIGTTLLLHCDLVYLGDNARLQLPFVELGLVPEFASSLLLPRAVGHLKAAELLLLAEAIDADEALRLGLANRVVAADELLALARDQGLKLAAKPPKALQKSKALLKQELKQAVHFVIDLEARAFSLALQGEEAQHRIAQRLKPRA
>NZ_CP022186.1|WP_005320497.1|4179486_4179927_-|copper-chaperone-PCu(A)C
MFKRAFYSLLALGLAAPALAKVEAVDGYVRLLPPGSPNTAAFLVLKNDADKPVKLVAAASPEVGRAELHTHLHENGVMRMRQVESIAIPAKGEVALKPGSFHVMLFEVRELSQGTPFPLTLTMDDGQTLELSLPVKPIEPMAGMQH
>NZ_CP022186.1|WP_005320467.1|4187402_4188104_-|YggS-family-pyridoxal-phosphate-dependent-enzyme
MSQIAQHLLQVKERIVQAARQADRCVDHINLLAVSKTKPLEAIREAYAAGQRRLGESYAQEAATKIDTLRKQAVCTDIEWHFIGPLQSNKSRLVAERFDWVQSVDRDKLIERLNNQRPAGLAPLNICLQINISGESSKSGTSEQEIFRLAELVSRSERLVLRGLMAIPEHTSDEAVLAAQMVRMQTLFTELAQQYPSVDTLSMGMTEDLELAIAHGSTMVRVGTAIFGARDYS
>NZ_CP022186.1|WP_005320466.1|4188143_4189178_+|type-IV-pilus-twitching-motility-protein-PilT
MDITELLAFSVKHKASDLHLSAGVPPMIRVDGEVRKINLPALEHREVHALIYDIMNDHQRKELEENFEVDFSFEVPNLARFRVNAFQQSRGSGAVFRTIPSTVLSLEDLDAPEIFRKISEYPRGLVLVTGPTGSGKSTTLAAMVNYINENFHHHILTIEDPIEFVHENKRCLVNQREVHRDTKSFSNALRSALREDPDIILVGEMRDLETIRLAMTAAETGHLVFGTLHTSSAAKTIDRIIDVFPGAEKDMVRSMLSESLRAVISQTLLKRIGGGRVAAHEIMMGIPAVRNLIREDKIAQLYSVIQTGMTHGMQTMDQSLKQLVSRGVVASLDAKAKAVDPNSV
>NZ_CP022186.1|WP_005320465.1|4189213_4190323_+|PilT/PilU-family-type-4a-pilus-ATPase
MNLDALLAELVARKGSDLFITVGTPPTLKINGHLVSLGSEALDKQSALTLVRETLSPEHFERYIRTREGNYAIHREALGRFRVSAFWQQELPGMVVRRIETRIPTFDELTLPPILQEVAMAKRGLVLFVGATGTGKSTTQAAMIGYRNQNADGHILTVEDPVEFVHQHGRSLITQREVGIDTESFDVALKSSLRQAPDVILIGEIRSQETMEFALQFAETGHLCLATLHANNANQALDRILHLVPQEKHRQLLFDLSFNLRAIVAQQLVPSLDGRRRFAAFEVLLNTPLITDIIRKGEVHRLKEVMTKSTELGMQTFDQALFTLFCAGQIGYSEALAHADSANDLRLLIKLSGREQMGAGTLDNVTLDE
>NZ_CP022186.1|WP_005320464.1|4190354_4191128_+|peroxide-stress-protein-YaaA
MLIVVSPAKTLDYESPLVISRFTQPQLLDHSAELITRARQLSPDQIASLMKISDKLAGLNAARFAQWQHDFHPDNARQALLAFKGDVYTGLAVEDFSDGDFDFAQAHLRMLSGLYGVLRPLDLMMPYRLEMGTRLDNSRGKDLYQFWGDVITQHINAALTAQGDEVLINLASDEYFKSVRPKALKGRIVTPVFKDEKNGQFKIISFYAKKARGMMARHIIKHRLTEVEQLTGFNVDGYYFVPEESDAHTLMFKRAEN
>NZ_CP022186.1|WP_005320462.1|4191316_4192540_-|ATP-dependent-RNA-helicase-SrmB
MSQSFDDFDLHPALNRALAEMGFTRPTTIQQMVLEPALDGRDILASAPTGTGKTAAFVLPALQHLLDFPRRKPGPCRMLILTPTRELALQVTAHAKALAVHTNLSIETIIGGVSHEEQLPALTKTTDIVVATPGRLLEYIDKEEFESHDIEVLVLDEADRMLDMGFVKDVNRIVAEARYRKHTMLFSATLEGAGLEKFANEILNEPVELHAEPPRSERRPITQWVHLADDAAHKLALLIHILKDPETQKAIVFVRTRERLAELSGQLQAAGIPCAWIRGEMEQSKRVESIRKFHAGEVPFLVATDVAARGIDLPNVSHVINYDMPYGTDVYVHRIGRTGRAGNRGCAISLVEAHDMGMVAKIERYTEERLKRRVIDELRPKHKEARVPVKKKKPKDGKKKSAKKKKK
>NZ_CP022186.1|WP_017412061.1|4192668_4193379_+|methyltransferase
MGRNSGFTFKQFHVEHDRCAMKVGTDGILLGAWAPVAETRRVLDIGTGSGLVALMLAQRSRSDCIIDAVELDMNAATQARENVAASPWETRINIMEGAIQDYQATPYDLIVSNPPYFGAGQSLRDPARALARHTGSLDSRDLLAACDRLLTPVGQVALVLPTAMADEILCISADYDLHGVCYTAVITRAGKEANRVLLLLGRGLNRCEQGEIVIHSAGGAYSDRYIQLTHPFYLKM
>NZ_CP022186.1|WP_011899101.1|4193570_4194878_+|branched-chain-amino-acid-transport-system-II-carrier-protein
MTKSLTLSDVLGLGFMTFAFYLGAGNIIFPPLAGYMAGEHLSLAMLGFLVTAVGLPLITIIAVAKAGNGWAGMTKFLPAGLATALAVAIYIIIGPAFAAPRTGLVAYEMGLKPFIGDMGQAGLAAYTVIFFGIAILVSLNQGKLMDTIGKYLMPVLMVLLLTLAVGVFVAPQGTIPSATGDYLEGPFVKGILEGYNTMDTLASLMFGALIIDLLRQKGINDYKSQFKYLAIAGLISAIGLSVVYVSLFQLGNTAAGVATDVSNGGAIVNAYVLSLFGQPGQFILAGIITLACFTTAVGLISACSDFFHNLTGMSYKKLVVLLGTICAIVANVGLSQLISLSIPVLVAIYPVAVALVLVTFLKGYFGRPRLAFRSVLMVAFLFGCLDGLGAAGMKMDAFAFLPLFDKGLAWLLPTLLACGLGMAVRSSEKLAAEAA
>NZ_CP022186.1|WP_085941509.1|4194953_4195217_-|hypothetical-protein
MPPSKSVSSNAMWKALKWLFIGWVLLLILSDVQISTSLYKYDDNKVVVSFPRWQADRPWGTFQWHAGRIETHWYGLEGKPKPIVPLL
>NZ_CP022186.1|WP_005320452.1|4195188_4195650_-|chemotaxis-protein-CheX
MKADFVNPFLLSLLNVLSTMAQLELRPGKPKRKMDELARGDVSGLIGMVGPQTRGSLSISFEKGLALEIMRRMLGEAPATINEEVTDMVGEITNMVTGGAKRMLGEKGYEFDMATPIIVSGPNHTITHRADGTKIMMPFESDYGRATIEICFE
>NZ_CP022186.1|WP_005320451.1|4195639_4196098_-|zinc-uptake-transcriptional-repressor-Zur
MNQDQLLQRAERLCEQRGIRFTPTRRQVFTLLAAHGNAISAYDLLAQLQQTEAHAKPPTVYRALDFLLEQGFAHKVESLNAFIFCCHFDHAHPMQLLICDECGDVVELHDTAIDSAFSEQAHQHGFTITNKTIEAHGQCARCTPTVGSQHEG

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Crispr_ID: NZ_CP022186_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_8

4450264-4450406

Orphan

Consensus_repeat	Method
CGCCATTTGACAGGGTTCGGACTGATCTCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP022186_8

>merge|NZ_CP022186|8|4450264-4450406|CRISPRCasFinder
CGCCATTTGACAGGGTTCGGACTGATCTCGGGCAAGTCACGCCGGCCAGTTTCCAAATCGCCATTTGACAGGGTTCGGGCTGATCTCGAAGGCCACACAGAGTCGCAAGGCAGCATCATTGAACAGTGTTCGAGCTGCTCTCA

>NZ_CP022186|8|8|4450264-4450406|CRISPRCasFinder
CGCCATTTGACAGGGTTCGGACTGATCTCG	GGCAAGTCACGCCGGCCAGTTTCCAAAT
CGCCATTTGACAGGGTTCGGGCTGATCTCG	AAGGCCACACAGAGTCGCAAGGCAG
CATCATTGAACAGTGTTCGAGCTGCTCTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005319956.1\|4445769_4446525_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|168162
NZ_CP022186.1\|WP_005319966.1\|4449718_4450261_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|182158
NZ_CP022186.1\|WP_005319959.1\|4446610_4448107_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NZ_CP022186.1\|WP_005319951.1\|4443701_4444541_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238922
NZ_CP022186.1\|WP_088814336.1\|4459864_4460662_+\|nitrite-transporter-NirC	unknown	unknown	gnl\|CDD\|183200
NZ_CP022186.1\|WP_011899215.1\|4452049_4452340_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005319980.1\|4454371_4455019_+\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|273358
NZ_CP022186.1\|WP_085941537.1\|4441982_4442210_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005319939.1\|4440645_4441986_-\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|182409
NZ_CP022186.1\|WP_005318371.1\|4460689_4462096_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|182606
NZ_CP022186.1\|WP_005318375.1\|4459495_4459813_+\|nitrite-reductase-small-subunit-NirD	unknown	unknown	gnl\|CDD\|181921
NZ_CP022186.1\|WP_017411931.1\|4448213_4449545_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|181707
NZ_CP022186.1\|WP_005319948.1\|4442950_4443403_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|236820
NZ_CP022186.1\|WP_005319953.1\|4444657_4445773_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP022186.1\|WP_042467532.1\|4455154_4457917_-\|magnesium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|237914
NZ_CP022186.1\|WP_005319975.1\|4452465_4453368_+\|EamA-family-transporter-RarD	unknown	unknown	gnl\|CDD\|185328
NZ_CP022186.1\|WP_005319969.1\|4450544_4452041_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143430
NZ_CP022186.1\|WP_076611341.1\|4458368_4459286_+\|IS5-like-element-ISAs4-family-transposase	unknown	unknown	gnl\|CDD\|290455
NZ_CP022186.1\|WP_005319946.1\|4442336_4442849_+\|ferredoxin-type-protein-NapF	unknown	unknown	gnl\|CDD\|319886
NZ_CP022186.1\|WP_005319978.1\|4453436_4454255_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_005319956.1\|4445769_4446525_-\|glutamine-amidotransferase	gnl\|CDD\|168162	PRK05665, PRK05665, amidotransferase; Provisional.	3.2064e-68
NZ_CP022186.1\|WP_005319966.1\|4449718_4450261_+\|cupin-domain-containing-protein	gnl\|CDD\|182158	PRK09943, PRK09943, HTH-type transcriptional regulator PuuR.	1.28881e-47
NZ_CP022186.1\|WP_005319959.1\|4446610_4448107_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NZ_CP022186.1\|WP_005319951.1\|4443701_4444541_-\|carbohydrate-kinase	gnl\|CDD\|238922	cd01947, Guanosine_kinase_like, Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time.	2.00919e-57
NZ_CP022186.1\|WP_005319980.1\|4454371_4455019_+\|LysE-family-transporter	gnl\|CDD\|273358	TIGR00949, Uncharacterized_membrane_protein_YahN, The Resistance to Homoserine/Threonine (RhtB) Family protein. [Transport and binding proteins, Amino acids, peptides and amines].	2.3186e-31
NZ_CP022186.1\|WP_088814336.1\|4459864_4460662_+\|nitrite-transporter-NirC	gnl\|CDD\|183200	PRK11562, PRK11562, nitrite transporter NirC; Provisional.	3.90243e-173
NZ_CP022186.1\|WP_005319939.1\|4440645_4441986_-\|DNA-recombination-protein-RmuC	gnl\|CDD\|182409	PRK10361, PRK10361, DNA recombination protein RmuC; Provisional.	5.27863e-149
NZ_CP022186.1\|WP_005318371.1\|4460689_4462096_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|182606	PRK10637, cysG, siroheme synthase CysG.	0
NZ_CP022186.1\|WP_005318375.1\|4459495_4459813_+\|nitrite-reductase-small-subunit-NirD	gnl\|CDD\|181921	PRK09511, nirD, nitrite reductase small subunit NirD.	2.85715e-69
NZ_CP022186.1\|WP_017411931.1\|4448213_4449545_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|181707	PRK09221, PRK09221, beta alanine--pyruvate transaminase; Provisional.	0
NZ_CP022186.1\|WP_005319948.1\|4442950_4443403_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|236820	PRK11014, PRK11014, HTH-type transcriptional repressor NsrR.	5.50142e-51
NZ_CP022186.1\|WP_005319953.1\|4444657_4445773_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP022186.1\|WP_042467532.1\|4455154_4457917_-\|magnesium-translocating-P-type-ATPase	gnl\|CDD\|237914	PRK15122, PRK15122, magnesium-transporting ATPase; Provisional.	0
NZ_CP022186.1\|WP_005319975.1\|4452465_4453368_+\|EamA-family-transporter-RarD	gnl\|CDD\|185328	PRK15430, PRK15430, EamA family transporter RarD.	1.20149e-124
NZ_CP022186.1\|WP_005319969.1\|4450544_4452041_+\|aldehyde-dehydrogenase	gnl\|CDD\|143430	cd07112, ALDH_GABALDH-PuuC, Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like. NADP+-dependent, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (GABALDH) PuuC of Escherichia coli which catalyzes the conversion of putrescine to 4-aminobutanoate and other similar sequences are present in this CD.	0
NZ_CP022186.1\|WP_076611341.1\|4458368_4459286_+\|IS5-like-element-ISAs4-family-transposase	gnl\|CDD\|290455	pfam13737, DDE_Tnp_1_5, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	2.87975e-48
NZ_CP022186.1\|WP_005319946.1\|4442336_4442849_+\|ferredoxin-type-protein-NapF	gnl\|CDD\|319886	cd10564, NapF_like, NapF, iron-sulfur subunit of periplasmic nitrate reductase. This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	1.25455e-41
NZ_CP022186.1\|WP_005319978.1\|4453436_4454255_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	7.93867e-28

>NZ_CP022186.1|WP_005319966.1|4449718_4450261_+|cupin-domain-containing-protein
MDIGHRLKAVRTKAALSQRELAKRSGVTNGFISQIEKNQVSPSVSSLRKVLEGIPMSLASFFTEETEMGTEVIFRASDMPDLGTHPISYRLVGHSRANRAIGMMQEILPPGADTGDDMLSHEGEECGIVIQGTVEVTIGEQIHQLAPGDGYYFDSRTPHRFRNVGEQECVLISANTPASF
>NZ_CP022186.1|WP_017411931.1|4448213_4449545_-|aspartate-aminotransferase-family-protein
MKPISDINTPSDMSAFWMPFTANQQFKAAPRILKSAEGMYYHSEDGRKILDGTAGLWCCNAGHGRREIAEAVSQQISHLDFAPTFQMGHPLPFELANQLVEIAPQGFGHVFYTNSGSESVDTALKIALAWQRARGQGTRTRLIGRERGYHGVGFGGISVGGIPGNRKWFGSLLTGVDHLPHTLNIAKHAFTRGLPDEDVTLADELEKIVFLHDASNIAAVIVEPIAGSTGVIMPPKGYLKRLREICTKHGILLIFDEVITGFGRLGSPFAAQEFDVIPDMITCAKGLTNGAIPMGAVMVRNGIYDDMMAAGKGAIELFHGYTYSGHPVAAAAALATLDIYRNENLLTRAADLAGYWEEAAHSLKGCKHVKDVRNYGLVAGIELESMPDAPGKRAYEVFVRCFEKGALVRVTGDIIALSPPLIIERSQIDDLFTLLQDVLQTQD
>NZ_CP022186.1|WP_005319959.1|4446610_4448107_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MTYRVSNFIDGQLQQSHSERFGAIFNPATGQQQGSVALATAAECGEAIAVAERAFTDWSQTPPLVRARVLFRFKELMERHRDELAELISREHGKVFSDAQGELTRGLEVVEFACGIPHLLKGEHSLNVGRGVDSHSMMQPVGVCAGITPFNFPAMVPLWMFPVAIACGNTFILKPSEKDPSLSLRMAELLKQAGLPDGVLNVVNGDKEVVDVLLTDPRVGAVSFVGSTPIAEYIYATASAHGKRVQALGGAKNHMLVMPDADLDQAVSALMGAAYGAAGERCMAISVAVVVGDETADALVAKLAPLVETLRVGPGLGQVPENEMGPLISREHLAKVRSYVDQGVAEGALLRVDGRGVSHGEGYFIGGSLFDEVTPEMRIYREEIFGPVLAIVRAPDYETALGLINQHEYGNGTAIFTCDGDTARDFTARVQVGMVGVNVPIPVPMAFHSFGGWKRSIFGPLNMHGPDGVRFYTRMKTVTARWPQSLRAGAEFSMPTMK
>NZ_CP022186.1|WP_005319956.1|4445769_4446525_-|glutamine-amidotransferase
MRLGILDCDRLDPDLADHFGPVYSEMFIKGFRALAPELEFRIWSALDGELPDDLQECDAWLITGSRHDAYSDLPWIQALRAWIRLAHDADVKLAGVCFGHQVIAQALGGEVVKSTKGWGLGVSVHPMLATGSWMQPGLDQIRILASHQDQVALLPPGATRLAGNDFCPNFMFLQGDHIVAIQGHPEFSVEYNRALIERRRDFLSDDRYQSSLSSLEGEVDSATMMQWLLQFLGILPGSERAAGGITAGERA
>NZ_CP022186.1|WP_005319953.1|4444657_4445773_-|alanine-dehydrogenase
MIIGVPKEIKNHEYRVGMTPAGVQELAARGHKVLVQQQGGEAIGLSDAEYQAAGAELVASAAEIFARAEMIVKVKEPQPEECELLRPGQLLFTYLHLAPDPVQTQLLVHSGAVAIAYETVTDERGGLPLLAPMSEVAGRMAIQAGAHSLEKAQGGNGTLLGGVPAVAPAKVVVLGGGVVGVNSARMALGLGADVTILDRSLPRLRELDSLYGPALKTLYSTRTNIEACIAQADLVIGAVLIPGAAAPRLLTRDMLKLMRKGSVLVDVAIDQGGCFETSHPTTHEEPTYVVDGIIHYCVANMPGGVARTSTFALTNATLPFVLALADKGYAQALKDDKHLRAGLNVFKGKVTQAAVAQALGYEYVSAESVLG
>NZ_CP022186.1|WP_005319951.1|4443701_4444541_-|carbohydrate-kinase
MSRILLLANLNCDHVLSLSEPLVAGARLQYVDQGRRLGGGAANTGIGLVWAGHEVTIASRIGLDEAGDWLLEQAAGYGLDCSHVERFGGETGELLILVDSTGERTILRRPRRPDLPGDLPVEGVDCLYVNYPGTAITGYMRQMLGKSFVVAQYPKGGQARRPCHVLVASRSDLGEVSAPWLHARQLAGEQLEWLVLTEGKAGAVAIHGEEQIRVAARPVSVVDTTGAGDAFAGGLIHGLARGMAIQDALQCAVDWGAFAVASESSIPSTALKNWLKQPH
>NZ_CP022186.1|WP_005319948.1|4442950_4443403_-|Rrf2-family-transcriptional-regulator
MQLTRFTDYALRTLTFLAVQPGDRLSTITEVADTFAISRNHVVKIVHQLGIKGYIETVRGKHGGIRLGRSAVSINLRDVVMDMEHVLCPVDCKRENCRLSGGCRIQGILRRAMNAFLEVLGEYTLADAVRDPTRLCHLLGIEHDSILAMA
>NZ_CP022186.1|WP_005319946.1|4442336_4442849_+|ferredoxin-type-protein-NapF
MTHFFCRWLTHALGGTRKPDVVCHEARPPWAIEESQYLSLCTRCGECFKACPNGLLKPASQPEYEGTAIAGTPVLDLACGQCSYCGSCARACPTGALDLQWGRQVQTRVQIEASCQARQGFYCLLCEDACPQQAIKATSDGVSVNMAACDGCGACGLACLHGAITLIPQL
>NZ_CP022186.1|WP_085941537.1|4441982_4442210_-|hypothetical-protein
MNELMWLFLWRASLLYIFPLLMWAYCRIKGIEFAELDTGVNSHKWVVLAAYLLYVLLWLLLNRYLELFLRQRSRK
>NZ_CP022186.1|WP_005319939.1|4440645_4441986_-|DNA-recombination-protein-RmuC
MIELATWGPALLAALLALCVGWLAGRRFASAQEQELLLTQERHQALQDRFDELQDERMQGQQKLDQQQTLLIKLTARLKDAEATLRSERLAAAEKLQLQRDGEQRLSQQFENLANRIFEQNSGNFRDLNQNSLDLLLTPLKEQLEGFRRQVGETHAQETAQRHSLKFELERLAELNARMTEEAAALTRALKGDSKQQGNWGEVVLARILSECGLREGHEYHTQVNIELDKGKRYQPDVIVHLPQEKDIIIDAKVSLTAYERWYNTDDALEKAVALKEHVASVRNHIRELGRKDYQQLPGVRTLDYVLMFVAVEPAFLTALEADPSLVRFGLDNNILLVSPTNLMVALRTIENLWRYERQNQNARQIAERAGRLYEKLRLFVEEMQQMGGSLHKAQESYDKAMGRLVNGRGNLIAQVERFRELGVEVTKPLPETLVNRALEREDPAE
>NZ_CP022186.1|WP_005319969.1|4450544_4452041_+|aldehyde-dehydrogenase
MSDLTLAQWQHKAAHLTLPSQAFIDGSYRDAINGATFDCINPANGKLLTKVAACDAADAELAVQAARAAFNDKRWSGLAPKQRKLIMQRFADLMRLNKVELALLESLDMGKPIGDAMGYDAPAAANCIAWNAEAIDKIYDQVAPVEESALALVTREALGVVAAIVPWNFPLVMACWKLGPALATGNSVILKPSEKSPLTALRIAGIAKEAGIPDGVFNVLPGFGHTVGEALAMHMDVDCITFTGSTKIGKHLVECSGKSNLKRAFMECGGKSPNIILADAPDLDAAAKSAAGAIFYNQGEVCTAASRLLVQNSIKPKFMERLLAHAREWIAANPLDPATRIGAMVDGIQMEQVLRYIDIGQQEGAKLLLGGKRTNMESGGFYIEPTIFDEVTPEMRIFREEIFGPVLAVTGFDTLEEAIALGNDTDYGLAAALWTADLNKAIKGSRALRAGTVFVNNWDGGDMTMPFGGFKQSGNGRDKSLHALEKYTELKSTWIQLE
>NZ_CP022186.1|WP_011899215.1|4452049_4452340_+|hypothetical-protein
MTLIREIGGEILLFHFCPFIARLNRYNRQLDKPLNIKIKMLFFLGSVLFLVIGLPLLFYLLGQGEAYVIWGPWISAIALMLWLLLDVEKIRRGGGR
>NZ_CP022186.1|WP_005319975.1|4452465_4453368_+|EamA-family-transporter-RarD
MQQQVQRQGIIYALCAYTLWGLAPIYFKTLSAVPAAEILTHRMIWSCVLLMVLTLLGRQWHKVQAVLRQPKVLLTLAFTSVTVGGNWLLFIWAINNGHMLDASLGYYINPLFNVLLGMLFLSEQLRRLQWWAVGLAVIGVTVQLIAFGSLPWIALVLASSFAIYGLIRKKLALDALTGLLIETMIMLPPAAIYLWGFADSPTSHMTENDWHLNLLLIAAGAVTTAPLLCFTAAATRLKLSTLGFFQYIGPSLMFILAVTLYGEALTPDKLITFGCIWSALVLFSLDGLRSGKRRRAASQG
>NZ_CP022186.1|WP_005319978.1|4453436_4454255_+|AraC-family-transcriptional-regulator
MSAPQSRIHYWQSRLLPGVELSHSHHREFSYGRHVHLDYHIGLVQQGGQKFIHKGSSHNLVRGELSTVNPDEMHDGLSLLPEGYEVRVFAIAPEQLARWLPDSPEPFFDKGLQSRPDLYQGFARLHMYLDTPQADGLLAESQLLALLGELLHIAPERHALADPQLRYLRDYLLARLDERHSLEDLAALFGLDRFAFLRQFKKKTGMTPYAWLKRLRLEQGKRLLGSGLPVSEVALAVGFFDQSHFHHGFRQAFGLTPADYRQQMQSFTGQPG
>NZ_CP022186.1|WP_005319980.1|4454371_4455019_+|LysE-family-transporter
MFTSLFLTIGLIHLIALASPGPDFALILRTSLHRPTALGAALGIALAILLHATLSLTGISLLIAEHPWLFMAVKVVGALYLGWLGWGALKAAWHSSATLALKAGGEQQGWRKGIGSGLATNLLNPKALLFFMGLLAAMVTPQVDGLTRGLLVLELFLLSLVWFGVLAWSLSTPRAQRLLGRIQRPLNLVTGLLFGAVSLSILTGMAGEAYALVPH
>NZ_CP022186.1|WP_042467532.1|4455154_4457917_-|magnesium-translocating-P-type-ATPase
MKQQHTASRHKQKGFVSPGRANEKLSSRVLDEADKSLEYTLTAVRGNIDGLTSTEAANRLVQFGPNEVTHDKPPHPLIQLMQAFKNPFVMVLIVLGLVSYVMDVLMAEPGDEDWVKVIILGVMVSLSGLLRFWQEYRSAKAAETLKSLMRNTATVLRHPSPGAPSQRKEVAMVELVAGDIVHLQAGDMIPADIKLIESRDLFISQAVLTGEALPVEKYDTLGAVAEKSADGSSTGEVGLLDLPNICFMGTNVVSGTAKAVVVATGSDTYFGSLARNVVSHKRIETSFDRGVNSVTRLLIRFMLVMVPVVFMLSGVSSGDWMSALTFALAVAVGLTPEMLPMIVSANLARGAVAMAKRKVVVKRLNSVQNFGAMDVLCTDKTGTLTQDKIILEHHYDVRGSRDDRILQLAWLNSYHQSGMKNLMDIAVIEHADVLGDSCKPSNYSKVDELPFDFVRRRLSVIVQDDLGQQLMVSKGAVEEMLSVSSHIDDGKQIRELDEIERRALLRRSEEYNADGYRVLIVATRDIPAAECKQSYRTSDEAGLVVRGFLTFFDPPKDSAAPAIRALNDYGVAVKVLTADNPIITSKVCRDVGLNPGVPLLGKDIEVMDDVALCTVVKHTTIFAKLTPLQKSRVVKALQANGNTVGFLGDGINDAPALRDADVGISVDSGADIAKETADIILLEKSLMVLEEGVVKGRETFGNILKYLNMTASSNFGNVFSVLVASAWLPWAPMLAMQMLIQNLVYDVSQMLLPWDKMDPEFLKRPRKWEASNIKRFMLWLGPTSSVFDISTFCLMWFVFGAGAMYATANGSMDPLVNGQAIMNSGWFIEGLVSQTLVVHMLRTRKIPFLQSTATLPVLLSTSIAIAIGCYLPFSPLAEHFGFITLEAPRYFMWLVITMLAYMGLTQAIKTIYIKRHGQWF
>NZ_CP022186.1|WP_076611341.1|4458368_4459286_+|IS5-like-element-ISAs4-family-transposase
MGKALHPITNWPQYNRSLINRGSLTFWVDAEAMDNWFHQDHHGKRGRSQLYTDQSICTFLMLKGIFSLTLRATQGLLDSLFELMNVPLCAPDYSCVSKRARTVKVAYRQPPKGRITDLVIDSTGLKVFGEGEWKVRKHGAEKRRVWRKLHLAVDPVTHDIVAAEVSLENVHDAEVLPTLLNPLRRKLGRVYADGAYDSKASHRLIARKGATACIPPRKNAGLWKKGHPRNEAVQVMRKEGLAHWKKISGYHRRSLAETAMFRFKQLMAGQITLRKYNGQVGEVMAYVSAINKLNTLGLPVRKPRV
>NZ_CP022186.1|WP_005318375.1|4459495_4459813_+|nitrite-reductase-small-subunit-NirD
MKFACQLNDILPGTGVCALIEGRQIALFRPSAAAEVFAIDNRDPFFAANVLSRGLICEHEGALWVASPLKKQRFRLSDGHCFENPAMSIASYAVEVRDQQVWVAV
>NZ_CP022186.1|WP_088814336.1|4459864_4460662_+|nitrite-transporter-NirC
MYTETINKCAANAARINRFERSDKLGFWLSSAMAGAYVGLGIILIFTLGNLVDPSIRPLVMGATFGIALTLVIIAGSELFTGHTMFLTFGVKTGKITMTDLLRILPQTWAGNLLGSIAVALIYSYGGSLLPDAGSLAHKVALAKTQAPALTLFMKGILCNWLVCLAIWMALRTEGAAKFIAIWWCLLAFIASGYEHSVANMTLFALSWFGAHSEAYTLGGIGHNLLWVTLGNTVSGALFMGLGYWYATPKADRPVAVTDANAAAS
>NZ_CP022186.1|WP_005318371.1|4460689_4462096_+|uroporphyrinogen-III-C-methyltransferase
MDYLPIFCRLDNKPVLLVGGGEVAERKARLLLDAGARLTVVSPALDPELAALATSGTIDWLAAEFEPAHLTGKWLVVAATDRREVNALVYQSANQAGIFANVVDDPKRSSFIMPSIIDRSPLMVAISSGGKAPVLARLLREKLEALLPQHLGAVAAFAGGLRARVKARFASMGERRQFWERLLSADRLGQALARGDKASANQLADTLFAEETGAKGEVILVGAGPGDPGLLTLHALRHMQQADLVVYDQLVSDEVMALVRRDARRIFVGKQAGNHCVPQEGINQLLLEEASKGQRVVRLKGGDPFIFGRGGEELETLVGSGVGFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFVTAHGKGGTQDLDWPLLARDQQTLVFYMGLSSCATIRQKLTAHGKAGTTPVALIERGTQLNQRVIRGTLDQLPELAVGVESPALIMVGSVVTLADKLAWFGQTNHGVQAAALA

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Crispr_ID: NZ_CP022186_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022186_9

4467257-4467355

Orphan

Consensus_repeat	Method
AACTGATAGTTCAATCTTTATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022186_9

>merge|NZ_CP022186|9|4467257-4467355|CRISPRCasFinder
AACTGATAGTTCAATCTTTATGCTGCTGATTCGGCCAGCGGCCATTGTCGCCTAAGGGTCAAGACCATAGGCCCCAAACCGATAGTTCAATCTTTATGC

>NZ_CP022186|9|9|4467257-4467355|CRISPRCasFinder
AACTGATAGTTCAATCTTTATGC	TGCTGATTCGGCCAGCGGCCATTGTCGCCTAAGGGTCAAGACCATAGGCCCCA
AACCGATAGTTCAATCTTTATGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022186.1\|WP_005318362.1\|4465740_4466226_+\|ribonuclease-E-activity-regulator-RraA	unknown	unknown	gnl\|CDD\|236487
NZ_CP022186.1\|WP_005318348.1\|4469576_4471400_-\|ATP-dependent-DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|182933
NZ_CP022186.1\|WP_005318340.1\|4473170_4473875_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_CP022186.1\|WP_085941554.1\|4471542_4471998_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|183276
NZ_CP022186.1\|WP_034282043.1\|4463741_4465595_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP022186.1\|WP_005318352.1\|4469172_4469475_+\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|225418
NZ_CP022186.1\|WP_005319980.1\|4454371_4455019_+\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|273358
NZ_CP022186.1\|WP_011898246.1\|4476892_4477978_-\|polyamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270377
NZ_CP022186.1\|WP_042468407.1\|4473920_4474763_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|182574
NZ_CP022186.1\|WP_042468405.1\|4467640_4469068_-\|YdiU-family-protein	unknown	unknown	gnl\|CDD\|234583
NZ_CP022186.1\|WP_005318375.1\|4459495_4459813_+\|nitrite-reductase-small-subunit-NirD	unknown	unknown	gnl\|CDD\|181921
NZ_CP022186.1\|WP_076611341.1\|4458368_4459286_+\|IS5-like-element-ISAs4-family-transposase	unknown	unknown	gnl\|CDD\|290455
NZ_CP022186.1\|WP_005318344.1\|4472122_4472650_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022186.1\|WP_005318334.1\|4474759_4475665_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|182646
NZ_CP022186.1\|WP_005318359.1\|4466497_4467172_-\|7-cyano-7-deazaguanine/7-aminomethyl-7--deazaguanine-transporter	unknown	unknown	gnl\|CDD\|183041
NZ_CP022186.1\|WP_088814336.1\|4459864_4460662_+\|nitrite-transporter-NirC	unknown	unknown	gnl\|CDD\|183200
NZ_CP022186.1\|WP_005318369.1\|4462246_4463671_+\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148
NZ_CP022186.1\|WP_042467532.1\|4455154_4457917_-\|magnesium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|237914
NZ_CP022186.1\|WP_042468409.1\|4475661_4476816_-\|polyamine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|183226
NZ_CP022186.1\|WP_005318371.1\|4460689_4462096_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|182606

Protein	Function_ID	Function_description	E-value
NZ_CP022186.1\|WP_005318362.1\|4465740_4466226_+\|ribonuclease-E-activity-regulator-RraA	gnl\|CDD\|236487	PRK09372, PRK09372, ribonuclease E inhibitor RraA.	3.36801e-99
NZ_CP022186.1\|WP_005318348.1\|4469576_4471400_-\|ATP-dependent-DNA-helicase-RecQ	gnl\|CDD\|182933	PRK11057, PRK11057, ATP-dependent DNA helicase RecQ; Provisional.	0
NZ_CP022186.1\|WP_085941554.1\|4471542_4471998_+\|thioesterase-family-protein	gnl\|CDD\|183276	PRK11688, PRK11688, thioesterase family protein.	6.82968e-82
NZ_CP022186.1\|WP_034282043.1\|4463741_4465595_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.60308e-72
NZ_CP022186.1\|WP_005318352.1\|4469172_4469475_+\|c-type-cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	5.31089e-25
NZ_CP022186.1\|WP_005319980.1\|4454371_4455019_+\|LysE-family-transporter	gnl\|CDD\|273358	TIGR00949, Uncharacterized_membrane_protein_YahN, The Resistance to Homoserine/Threonine (RhtB) Family protein. [Transport and binding proteins, Amino acids, peptides and amines].	2.3186e-31
NZ_CP022186.1\|WP_011898246.1\|4476892_4477978_-\|polyamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270377	cd13659, PBP2_PotF, The periplasmic substrate-binding component of an ABC putrescine transport system and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic substrate-binding domain that serves as the primary polyamine receptor of ABC-type putrescine-preferential transporter from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	0
NZ_CP022186.1\|WP_042468407.1\|4473920_4474763_-\|ABC-transporter-permease-subunit	gnl\|CDD\|182574	PRK10592, PRK10592, putrescine transporter subunit: membrane component of ABC superfamily; Provisional.	1.97935e-116
NZ_CP022186.1\|WP_042468405.1\|4467640_4469068_-\|YdiU-family-protein	gnl\|CDD\|234583	PRK00029, PRK00029, YdiU family protein.	0
NZ_CP022186.1\|WP_005318375.1\|4459495_4459813_+\|nitrite-reductase-small-subunit-NirD	gnl\|CDD\|181921	PRK09511, nirD, nitrite reductase small subunit NirD.	2.85715e-69
NZ_CP022186.1\|WP_076611341.1\|4458368_4459286_+\|IS5-like-element-ISAs4-family-transposase	gnl\|CDD\|290455	pfam13737, DDE_Tnp_1_5, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	2.87975e-48
NZ_CP022186.1\|WP_005318340.1\|4473170_4473875_-\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	1.3159e-65
NZ_CP022186.1\|WP_005318334.1\|4474759_4475665_-\|ABC-transporter-permease-subunit	gnl\|CDD\|182646	PRK10683, PRK10683, putrescine transporter subunit: membrane component of ABC superfamily; Provisional.	4.78085e-152
NZ_CP022186.1\|WP_005318359.1\|4466497_4467172_-\|7-cyano-7-deazaguanine/7-aminomethyl-7--deazaguanine-transporter	gnl\|CDD\|183041	PRK11212, PRK11212, 7-cyano-7-deazaguanine/7-aminomethyl-7-deazaguanine transporter.	1.30694e-130
NZ_CP022186.1\|WP_088814336.1\|4459864_4460662_+\|nitrite-transporter-NirC	gnl\|CDD\|183200	PRK11562, PRK11562, nitrite transporter NirC; Provisional.	3.90243e-173
NZ_CP022186.1\|WP_005318369.1\|4462246_4463671_+\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	2.62756e-151
NZ_CP022186.1\|WP_042467532.1\|4455154_4457917_-\|magnesium-translocating-P-type-ATPase	gnl\|CDD\|237914	PRK15122, PRK15122, magnesium-transporting ATPase; Provisional.	0
NZ_CP022186.1\|WP_042468409.1\|4475661_4476816_-\|polyamine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|183226	PRK11607, potG, putrescine ABC transporter ATP-binding subunit PotG.	0
NZ_CP022186.1\|WP_005318371.1\|4460689_4462096_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|182606	PRK10637, cysG, siroheme synthase CysG.	0

>NZ_CP022186.1|WP_005318359.1|4466497_4467172_-|7-cyano-7-deazaguanine/7-aminomethyl-7--deazaguanine-transporter
MNLTPAQHRTALVRLSLFHILIIASSNYLVQLPITIFGFHTTWGAFSFPFIFLATDLTVRIFGAGLARKIIQTVMLPALTVSYVLSVLFFEGSFQGVGNLAEFNLFVARIALASFMAYLVGQFMDVVVFNRLRLLRAWWVAPAASTLFGNLVDTIAFFSIAFWRSTDPFMADHWVEIATVDYVFKLLISLGLFVPLYGVLLRYLSRKLVGEAGLAGLQTATRQA
>NZ_CP022186.1|WP_005318362.1|4465740_4466226_+|ribonuclease-E-activity-regulator-RraA
MEYNTSELCDIYQDMVDVLEPMLCSFGGRASFGGVITTVKCFESNGLIRELVKENGVGRVLLIDGGGSMRRALIDSDIATTAAENEWEGIVCYGCVREVDILEDLDIGIQALAAIPVGADSKDVGETDLPVNFGGVTFLPDDHLYADTTGVILSPEALDIE
>NZ_CP022186.1|WP_034282043.1|4463741_4465595_-|methyl-accepting-chemotaxis-protein
MLIRHKLILNTALVAVAMLVLSALFLYSSQVSRHLAEAQRNVDGLEIAMLNLRRAEKDFLIRKDLTFVERFNKELADFHTLNRTLSTDDNISVVHGELARLDQQMGLYGKAFNDLVSQQQTIGLGPEDGLYGRLRAAVHQVEEGLKQLDQQGLLVTMLQLRRAEKDFMLRSDIQYLERFQTLHKSFQDNLAALPEADRGKLEQASQQYRQDFVALVQGMQVLGLKEDEGLRNQMRDLVHQTEQGFAAVGQHIADELVRQTSRLNSLMLVCGGVIIVLIGVMSVLLGRSIDRPISRVNDTVNRIRQDNDLRLRIELKGADEMAQLAGNLDVMLGGFRHLIGDVKQSVHTLTEAADHLSSNVRRTSEGASRQLQETDQVATASTEMGSTIEEIARNTEQAANNAQATNIKAMEGRTAVENTVRQIRSLAGNLESSSREVAQLQKESETIGSVLDVIRGIAEQTNLLALNAAIEAARAGDQGRGFAVVADEVRSLAIRTQKSTQEIAGIISSLQKQTGSIVGMMATCREQGNSSSEQASTAGDLLGQITQDVTHIMDMSTQIAAAIEQQSLVANEVNRNVTNIRDIAQESSLMAEENAKSSHGLTEQAKLLHQAVAKYRV
>NZ_CP022186.1|WP_005318369.1|4462246_4463671_+|magnesium-transporter
MSHPVKNSAKQREKDRRRILTLLLADDALTDSLLDPQSAQDAAQRDQTGEIIRLVNRLPAADVADTLESLPPDERHALWQLVNEEKHGQILVEASETVWDSLINGMSDKALLHALRSLDIDDQIYLGQYLPRNLMGRLLTSMAPPQRDRVRDVIRYGKHTVGAMMDFEIITVRAEVSLATVQRYLRLRAKIPVNTDKLFVIDRRNRLQGELPLTTLLLHKPDTLVANVMERDPVTFDPEDNDEAAARTFERDDLISAAVVDAKGKLMGRLTVAEVVDLVYEESDTDLRRMGGISEDEDLFAPVSKAVKTRWAWLAINLCTAFVASRVIGLFEHTISQLVALAALMPIVAGIGGNTGNQTITMIVRALALQHIQAGNISFLLWRELGVALVNGLVWGGTMGVATYLLYQDPALGAVMTLAMMINLLVAALMGVMIPMTMTRLGRDPAIGASVMITAITDTGGFFIFLGLATLFLI
>NZ_CP022186.1|WP_005318371.1|4460689_4462096_+|uroporphyrinogen-III-C-methyltransferase
MDYLPIFCRLDNKPVLLVGGGEVAERKARLLLDAGARLTVVSPALDPELAALATSGTIDWLAAEFEPAHLTGKWLVVAATDRREVNALVYQSANQAGIFANVVDDPKRSSFIMPSIIDRSPLMVAISSGGKAPVLARLLREKLEALLPQHLGAVAAFAGGLRARVKARFASMGERRQFWERLLSADRLGQALARGDKASANQLADTLFAEETGAKGEVILVGAGPGDPGLLTLHALRHMQQADLVVYDQLVSDEVMALVRRDARRIFVGKQAGNHCVPQEGINQLLLEEASKGQRVVRLKGGDPFIFGRGGEELETLVGSGVGFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFVTAHGKGGTQDLDWPLLARDQQTLVFYMGLSSCATIRQKLTAHGKAGTTPVALIERGTQLNQRVIRGTLDQLPELAVGVESPALIMVGSVVTLADKLAWFGQTNHGVQAAALA
>NZ_CP022186.1|WP_088814336.1|4459864_4460662_+|nitrite-transporter-NirC
MYTETINKCAANAARINRFERSDKLGFWLSSAMAGAYVGLGIILIFTLGNLVDPSIRPLVMGATFGIALTLVIIAGSELFTGHTMFLTFGVKTGKITMTDLLRILPQTWAGNLLGSIAVALIYSYGGSLLPDAGSLAHKVALAKTQAPALTLFMKGILCNWLVCLAIWMALRTEGAAKFIAIWWCLLAFIASGYEHSVANMTLFALSWFGAHSEAYTLGGIGHNLLWVTLGNTVSGALFMGLGYWYATPKADRPVAVTDANAAAS
>NZ_CP022186.1|WP_005318375.1|4459495_4459813_+|nitrite-reductase-small-subunit-NirD
MKFACQLNDILPGTGVCALIEGRQIALFRPSAAAEVFAIDNRDPFFAANVLSRGLICEHEGALWVASPLKKQRFRLSDGHCFENPAMSIASYAVEVRDQQVWVAV
>NZ_CP022186.1|WP_076611341.1|4458368_4459286_+|IS5-like-element-ISAs4-family-transposase
MGKALHPITNWPQYNRSLINRGSLTFWVDAEAMDNWFHQDHHGKRGRSQLYTDQSICTFLMLKGIFSLTLRATQGLLDSLFELMNVPLCAPDYSCVSKRARTVKVAYRQPPKGRITDLVIDSTGLKVFGEGEWKVRKHGAEKRRVWRKLHLAVDPVTHDIVAAEVSLENVHDAEVLPTLLNPLRRKLGRVYADGAYDSKASHRLIARKGATACIPPRKNAGLWKKGHPRNEAVQVMRKEGLAHWKKISGYHRRSLAETAMFRFKQLMAGQITLRKYNGQVGEVMAYVSAINKLNTLGLPVRKPRV
>NZ_CP022186.1|WP_042467532.1|4455154_4457917_-|magnesium-translocating-P-type-ATPase
MKQQHTASRHKQKGFVSPGRANEKLSSRVLDEADKSLEYTLTAVRGNIDGLTSTEAANRLVQFGPNEVTHDKPPHPLIQLMQAFKNPFVMVLIVLGLVSYVMDVLMAEPGDEDWVKVIILGVMVSLSGLLRFWQEYRSAKAAETLKSLMRNTATVLRHPSPGAPSQRKEVAMVELVAGDIVHLQAGDMIPADIKLIESRDLFISQAVLTGEALPVEKYDTLGAVAEKSADGSSTGEVGLLDLPNICFMGTNVVSGTAKAVVVATGSDTYFGSLARNVVSHKRIETSFDRGVNSVTRLLIRFMLVMVPVVFMLSGVSSGDWMSALTFALAVAVGLTPEMLPMIVSANLARGAVAMAKRKVVVKRLNSVQNFGAMDVLCTDKTGTLTQDKIILEHHYDVRGSRDDRILQLAWLNSYHQSGMKNLMDIAVIEHADVLGDSCKPSNYSKVDELPFDFVRRRLSVIVQDDLGQQLMVSKGAVEEMLSVSSHIDDGKQIRELDEIERRALLRRSEEYNADGYRVLIVATRDIPAAECKQSYRTSDEAGLVVRGFLTFFDPPKDSAAPAIRALNDYGVAVKVLTADNPIITSKVCRDVGLNPGVPLLGKDIEVMDDVALCTVVKHTTIFAKLTPLQKSRVVKALQANGNTVGFLGDGINDAPALRDADVGISVDSGADIAKETADIILLEKSLMVLEEGVVKGRETFGNILKYLNMTASSNFGNVFSVLVASAWLPWAPMLAMQMLIQNLVYDVSQMLLPWDKMDPEFLKRPRKWEASNIKRFMLWLGPTSSVFDISTFCLMWFVFGAGAMYATANGSMDPLVNGQAIMNSGWFIEGLVSQTLVVHMLRTRKIPFLQSTATLPVLLSTSIAIAIGCYLPFSPLAEHFGFITLEAPRYFMWLVITMLAYMGLTQAIKTIYIKRHGQWF
>NZ_CP022186.1|WP_005319980.1|4454371_4455019_+|LysE-family-transporter
MFTSLFLTIGLIHLIALASPGPDFALILRTSLHRPTALGAALGIALAILLHATLSLTGISLLIAEHPWLFMAVKVVGALYLGWLGWGALKAAWHSSATLALKAGGEQQGWRKGIGSGLATNLLNPKALLFFMGLLAAMVTPQVDGLTRGLLVLELFLLSLVWFGVLAWSLSTPRAQRLLGRIQRPLNLVTGLLFGAVSLSILTGMAGEAYALVPH
>NZ_CP022186.1|WP_042468405.1|4467640_4469068_-|YdiU-family-protein
MKLINTFATELPWACEPVVPQPLREPRLLHLNRGLLAELGLDGVSDTDWLACCGLGQPLPGMQPVAQVYAGHQFGGYSQRLGDGRALLLGEQLATDGQRWDLHLKGAGKTPFSRFGDGRAVLRSSIREYLASEALHALGIPTTRALVLVGSKEPVYREQEETGATVLRTAPSHLRFGHIEYFAWSGQGEKIPALIDYLLRYHFPELENGAELFAEVVRRTARLIAKWQAAGFCHGVLNTDNMSLLGLTLDYGPYGFIDAYVPDFVCNHSDPDGRYALDQQPAVGYWNLQKLAQALAGHVDGDALATSLAQYEHQLMLHYSELMRAKLGLTQWEEEDPALFRQLFQLLASQGVDYHLFLRRLGEVTGTGEWPASLLALLPDPDLWQGWLELYRVRLTREGGEDAVRKAQMDAINPKYVLRNALAQQAIDAAEGGDMTQFERLLAALQQPYDEQPEYADLATPVPQWYCGGELSCSS
>NZ_CP022186.1|WP_005318352.1|4469172_4469475_+|c-type-cytochrome
MQRWVYALPLLALAWGHLAKAADIEAGKAKAAVCAACHGVEGKALIPHYPHLAGQNHAYLVKQLKAFKDGSRQEPLMVPFMAPLTEADMENLAAFYASLK
>NZ_CP022186.1|WP_005318348.1|4469576_4471400_-|ATP-dependent-DNA-helicase-RecQ
MTVIAETLPDTPLALLQAVFGYQQFRPGQLEIIEQIVAGRDAMVLKPTGGGKSLCFQIPALLRPGLGVVVSPLISLMKDQVDSLRANGVAAIYINSALSREEMIQNFAAMRRGEIKLLYVSPERLLQHEFMDRLAELPLGLFAIDEAHCVSQWGHDFRPEYAALGRLKQWFPQVPVVALTATADEATRSDMLHRLELNDPFIHTASFDRPNIRYSLVEKFKAAEQLLRYVQSQKGNCGIVYCSSRNRVEEVAERLSRHGSKAAPYHAGLPLAQRQQTQDAFLKDDIEIVVATVAFGMGIDKPNVRFVVHYDIPKNIESYYQETGRAGRDGTPAEALLLYDPADIGRVRRLLDNIENPQQLQVEQYKLNVMAAFAEAQTCRRQVLLNYFGEYNDKPCGNCDICLDPPKSYDGTEDAQKALSCVWRVGQNFGVGYVVEVLRGSLNQRIKDHGHDKLSTYGIGKDQSHEYWMSVIRQLIHKGLLTQNITRNLVLQLTEASRPVLRGEMKLELAVPRLQPISSRKEKRNGLLDNANYDKRLFKELRGLRKQIAEDEEVPPYVVFNDATLVEMAQLMPMTEAEMLAINGVGHRKLERFGEAFMDLIIDYCRR
>NZ_CP022186.1|WP_085941554.1|4471542_4471998_+|thioesterase-family-protein
MLKKMALSGIANLFAERMPFNKLIGMQVTHYDFDKVELRIKMDDKLIGNPFHNILHGGVTASLLDVAGGMIVAASCIDELEDFSPNYLKERFSRLGTIDLRVDYLRPGRGNEFIATAHIIRAGSKVAVARMELHNEEGTHIAFGTGTYLVG
>NZ_CP022186.1|WP_005318344.1|4472122_4472650_+|hypothetical-protein
MSAKLATKPSRALLTQLESMLDEVQTPECRHWLEQELEGYSLCSHLPWYRIVACRQRGHFLDLKTGKYLTCHINSQTLSQRDLAQIQFIYAREPAAHYLLQRNSGIEPWPEQLLEDYQEQLIPGHLCLQAWHEPVSSLRSQLMEGIEHFISEYPKHAALQPQHSFKALRHQHWHI
>NZ_CP022186.1|WP_005318340.1|4473170_4473875_-|MOSC-domain-containing-protein
MRIFIFSGQGTELVPGLVSAINKQATTIPLWCGFGGLGGDEQSDPRHHGGPDRALHYYPADHYPWWHNWQTAMGLAAPRTPWQPAAFGENLSGLGLTEEQACIGDVYRLGEALIQISQPRSPCFKLNLRFGYPQLSQVMQLSVRCGWLLRVLEEGTVAPQETMELVDRPYPALTVKRTADILFNQVRHEADLLLLLENPALSPNWRQHAANWLEHGVVADWQRRLLGPAEFQFS
>NZ_CP022186.1|WP_042468407.1|4473920_4474763_-|ABC-transporter-permease-subunit
MKRFGFAKMMLWLGLLFIYLPMVIMVIYSFNSSKLVTVWGGWSLKWYFGLLDNKQLIGSVLRSLEIALYTAVAAVALGTVAAFVLTRIPHFRGRTLFGGMVTAPLVMPEVITGLSLLLLFVAMAQLVGWPAERGMLTIWIAHTTFCTAYVAIVVSARLRELDLSIEEAAMDLGAKPWKVFFLITIPMIAPSLAAGGMMSFALSLDDLVLASFVSGPGATTLPMEVFSAVRLGVKPEINAVVSLILLSVSLFTFSSWYLMARAEKRRRAEIAMTTQMQAVA
>NZ_CP022186.1|WP_005318334.1|4474759_4475665_-|ABC-transporter-permease-subunit
MKALRRLKRLGGRQLVIGIPFFWLFLFFLLPFIIVVKISFAEADVAIPPYTDVVSWADNQLTILLNLGNYLLLQEDELYIAAYIGSLKIAFISTVLCLLIGYPMAYTIARANKETQTVLLLLIMMPTWTAILIRVYAWMGILSNNGLLNSLLMGIGLIDEPLQILNTNLAVYIGIVYSYLPFMVLPLYANLVKHDQSLLEAASDLGARNLTRFWRITVPLSKNGIIAGCMLVFIPVVGEFVIPELLGGPETLMIGKVLWQEFFNNRDWPVASALAVVMLAVLIVPIILFNRNQAKELEGKV
>NZ_CP022186.1|WP_042468409.1|4475661_4476816_-|polyamine-ABC-transporter-ATP-binding-protein
MAIASSAYKKALEGNQQRKEVLVKIDRVSKQFDETLAVDNVSHNIHKGEIFALLGGSGSGKSTLLRMLAGFERPTEGRLFLDGVDITDMPPYERPINMMFQSYALFPHMTVAQNIAFGLKQDGLPKAEVDARVEEMLKLVQMAQYARRKPHQLSGGQRQRVALARSLAKRPKLLLLDEPMGALDKKLRSQMQLELVEIIERVGVTCVMVTHDQEEAMTMAERIAIMHLGCIEQIGSPMDIYETPASRLVCEFIGNVNLFDGLLVEDEQDHATIACADLEQPIYVGHGISSRAENKKVTYALRPEKLLMSTQKPTEIEHPDFNWTKGEVYDIAYLGGHSVYHIQLPSGKIVQAFIANAERHGKRPTWDDQVFLYWEDDSGVVLQS
>NZ_CP022186.1|WP_011898246.1|4476892_4477978_-|polyamine-ABC-transporter-substrate-binding-protein
MHTTKTVTMTLALGLASLAHAAPVVHFYNWSDYIGETTLSDFQQATGIKTVYDVFDSNETLEGKLLTGRTGYDLVVPSNNFLAKQITAGAFQKLDPALLPNLVNLDPVLLKQLDKVDPGHQYAVPYLWGTNGIGYNVDKIKDVLGVDKIDSWAVIFEPENMQKLSRCGVAFLDSADEMIPAVLNYLGLDPNSHKPEDIKRAEEQLLKVRPYVTYFHSSKYIGDLANGDICVAAGFSGDILQAAARADEAGKGINIAYSIPKEGGNLWFDMMAIPADATNVKEAHALINYVLQPEVIAKVSNYVGYANPNAKAGEYMDESVRDDESVYPPQAVLERLYVQQAHPRAVQRLITRSWTKIKSGT

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

108601 : 170328

Bacillus_phage(33.33%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|108601_109519_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_017411697.1\|109725_110064_+	DUF2799 domain-containing protein	NA	NA	NA	NA
WP_005321246.1\|110091_110256_-	hypothetical protein	NA	NA	NA	NA
WP_005321244.1\|110361_110796_-	flagellar basal body-associated protein FliL	NA	NA	NA	NA
WP_011899230.1\|110941_111478_+	chorismate lyase	NA	NA	NA	NA
WP_080697417.1\|111474_112344_+	4-hydroxybenzoate octaprenyltransferase	NA	NA	NA	NA
WP_005321239.1\|112402_114826_-	glycerol-3-phosphate 1-O-acyltransferase PlsB	NA	NA	NA	NA
WP_005321237.1\|115030_115654_+	repressor LexA	A0A1W6JNS2	Morganella_phage	1.7e-11	37.3
WP_005321232.1\|116106_116394_+	hypothetical protein	NA	NA	NA	NA
WP_005321230.1\|116603_117230_+	SCO family protein	NA	NA	NA	NA
WP_017411699.1\|117252_118638_+	MATE family efflux transporter	NA	NA	NA	NA
WP_042468614.1\|118619_119084_-\|tRNA	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	NA	NA	NA	NA
WP_042468613.1\|119165_120521_-	HAMP domain-containing protein	W8CYF6	Bacillus_phage	6.2e-19	27.3
WP_005321216.1\|120517_121213_-	response regulator	W8CYM9	Bacillus_phage	4.9e-36	39.6
WP_005321213.1\|121299_122211_+	cation diffusion facilitator family transporter	NA	NA	NA	NA
WP_011899226.1\|122219_122999_+	serine O-acetyltransferase	NA	NA	NA	NA
WP_042468612.1\|123020_124301_+	hypothetical protein	NA	NA	NA	NA
WP_085941539.1\|124386_124770_+	cell division protein ZapB	NA	NA	NA	NA
WP_005321205.1\|124841_125492_-	isoprenoid biosynthesis glyoxalase ElbB	NA	NA	NA	NA
WP_005321203.1\|125621_125858_-	hypothetical protein	NA	NA	NA	NA
WP_005321200.1\|125892_128649_+	DNA polymerase I	A0A218MKQ4	uncultured_virus	1.7e-71	32.9
WP_005321199.1\|128733_129273_-	gamma carbonic anhydrase family protein	NA	NA	NA	NA
WP_157668950.1\|129362_129620_-	hypothetical protein	NA	NA	NA	NA
WP_088814112.1\|135458_136376_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_017412531.1\|136461_137427_+	transcriptional regulator EbgR	C6ZCU4	Enterobacteria_phage	7.8e-16	25.0
WP_005320049.1\|137780_138731_+	bile acid:sodium symporter	NA	NA	NA	NA
WP_042468546.1\|138810_140961_-	5-histidylcysteine sulfoxide synthase	NA	NA	NA	NA
WP_005320045.1\|141308_142031_+	DUF2807 domain-containing protein	NA	NA	NA	NA
WP_042468548.1\|142094_142931_-	S-formylglutathione hydrolase	NA	NA	NA	NA
WP_005320041.1\|142981_144109_-	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	E3SJ82	Synechococcus_phage	2.1e-36	30.4
WP_042468549.1\|144229_145135_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_017412537.1\|145205_146171_-	ABC transporter permease	NA	NA	NA	NA
WP_005320035.1\|146173_147292_-	ABC transporter permease	NA	NA	NA	NA
WP_005320033.1\|147371_148952_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.5e-21	32.1
WP_017412538.1\|149035_150034_-	BMP family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005320031.1\|150462_152634_+	DNA helicase II	A7KV33	Bacillus_phage	1.4e-113	35.4
WP_005320028.1\|153188_153308_+	hypothetical protein	NA	NA	NA	NA
WP_139742341.1\|153660_153912_-	hypothetical protein	NA	NA	NA	NA
WP_005320018.1\|154799_155300_+	DUF1993 domain-containing protein	NA	NA	NA	NA
WP_042468550.1\|155395_155845_-	SRPBCC family protein	NA	NA	NA	NA
WP_005320010.1\|155919_156432_-	cupin domain-containing protein	NA	NA	NA	NA
WP_076611341.1\|157177_158095_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042469142.1\|158677_159706_-	YeeE/YedE family protein	NA	NA	NA	NA
WP_088814343.1\|159983_161120_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_076611341.1\|162017_162935_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814113.1\|162979_165565_-	nitrite reductase large subunit	NA	NA	NA	NA
WP_042468281.1\|165822_166743_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_005318384.1\|166933_168328_+	MFS transporter	NA	NA	NA	NA
WP_042468283.1\|168401_169730_-	HslU--HslV peptidase ATPase subunit	A0A2H5BJT2	Erwinia_phage	3.4e-46	29.9
WP_005318389.1\|169794_170328_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA

DBSCAN-SWA_2

282651 : 371811

Bacillus_phage(30.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|282651_283569_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_059114031.1\|284936_285551_+	outer membrane beta-barrel protein	NA	NA	NA	NA
WP_088814117.1\|287758_289234_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_088814118.1\|289298_290099_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_087756674.1\|290428_291325_+	methylenetetrahydrofolate reductase	NA	NA	NA	NA
WP_021140730.1\|291392_292457_-	DUF3103 family protein	NA	NA	NA	NA
WP_058407194.1\|292605_293757_-	benzoate/H(+) symporter BenE family transporter	NA	NA	NA	NA
WP_088814119.1\|293838_294408_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_088814120.1\|294424_295621_-	NnrS family protein	NA	NA	NA	NA
WP_042468088.1\|301661_301994_-	cupin domain-containing protein	NA	NA	NA	NA
WP_088814345.1\|302237_303581_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.1e-150	68.7
WP_005316680.1\|303819_304890_+	dihydroxyacetone kinase subunit DhaK	NA	NA	NA	NA
WP_017413041.1\|304905_305535_+	dihydroxyacetone kinase ADP-binding subunit DhaL	NA	NA	NA	NA
WP_005316674.1\|305536_306253_+	HPr family phosphocarrier protein	NA	NA	NA	NA
WP_042468090.1\|306412_307495_+	glycerol dehydrogenase	NA	NA	NA	NA
WP_042468093.1\|307588_309490_-	PTS-dependent dihydroxyacetone kinase operon transcriptional regulator DhaR	NA	NA	NA	NA
WP_088814121.1\|309653_310736_-	AI-2E family transporter YdiK	NA	NA	NA	NA
WP_042468094.1\|310738_312118_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_011899200.1\|312241_312694_+	hypothetical protein	NA	NA	NA	NA
WP_005316656.1\|312747_313521_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_088814122.1\|313666_314944_-	hypothetical protein	NA	NA	NA	NA
WP_017411879.1\|315159_315486_+	YnjH family protein	NA	NA	NA	NA
WP_042468096.1\|316031_317480_-	catalase	A0A2K9L0T1	Tupanvirus	7.9e-97	46.6
WP_017411878.1\|317641_318127_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_005316647.1\|318123_318984_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_005316644.1\|319109_320009_-	DMT family transporter	NA	NA	NA	NA
WP_005316642.1\|320155_320596_-	DUF2214 family protein	NA	NA	NA	NA
WP_005316639.1\|320705_322316_+	sensor domain-containing diguanylate cyclase	NA	NA	NA	NA
WP_005316638.1\|322354_323014_-	HAD-IB family hydrolase	NA	NA	NA	NA
WP_005316635.1\|323099_324107_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.9e-29	34.8
WP_005316629.1\|324881_325778_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_042468097.1\|325777_326611_-	alkaline phosphatase family protein	NA	NA	NA	NA
WP_005316623.1\|326620_327667_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_005316617.1\|328790_329555_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_017411874.1\|329993_330908_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_017411873.1\|331165_331498_+	hypothetical protein	NA	NA	NA	NA
WP_005316607.1\|331528_332215_+	pirin family protein	NA	NA	NA	NA
WP_005316605.1\|332255_332648_+	DoxX family protein	NA	NA	NA	NA
WP_042468099.1\|332880_336285_+	exodeoxyribonuclease V subunit gamma	NA	NA	NA	NA
WP_042468100.1\|336284_339905_+	exodeoxyribonuclease V subunit beta	A7KV33	Bacillus_phage	7.4e-11	22.8
WP_005316594.1\|339901_341965_+	exodeoxyribonuclease V subunit alpha	A0A1P8DII4	Virus_Rctr197k	1.0e-28	28.3
WP_088814123.1\|342033_342951_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814123.1\|344826_345744_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005316589.1\|345883_346282_-	hypothetical protein	NA	NA	NA	NA
WP_005316586.1\|346330_347344_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_088814343.1\|347561_348698_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_005316583.1\|348905_349538_-	porin family protein	NA	NA	NA	NA
WP_076611341.1\|349634_350552_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005316576.1\|352404_352743_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_005316573.1\|353241_354243_+	diguanylate cyclase	A0A127AWB9	Bacillus_phage	5.2e-15	32.4
WP_005316571.1\|354417_354846_+	hypothetical protein	NA	NA	NA	NA
WP_005316549.1\|358058_359474_+	sensor domain-containing diguanylate cyclase	NA	NA	NA	NA
WP_005316548.1\|361873_362086_-	RNA chaperone/antiterminator CspA	A0A1W6JNX5	Morganella_phage	1.1e-23	78.6
WP_088814346.1\|362638_364186_-	diguanylate cyclase	A0A127AWB9	Bacillus_phage	1.0e-17	32.1
WP_005316537.1\|364468_367297_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	5.2e-312	56.2
WP_017412640.1\|367392_368025_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005316531.1\|368544_369135_+	single-stranded DNA-binding protein	R9TR60	Vibrio_phage	1.0e-55	59.5
WP_005316528.1\|369303_370062_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_005316524.1\|370137_370260_-	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|370893_371811_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

435466 : 482490

uncultured_Caudovirales_phage(28.57%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088814129.1\|435466_436384_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814130.1\|436428_436812_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_076611341.1\|436868_437786_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005314155.1\|438217_439075_-	carboxylating nicotinate-nucleotide diphosphorylase	NA	NA	NA	NA
WP_088814131.1\|439079_439607_-\|protease	clan AA aspartic protease	NA	NA	NA	NA
WP_005314151.1\|439699_440272_+	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	A0A076YN96	Rhizobium_phage	3.2e-09	30.4
WP_005314150.1\|440548_441313_+	pyruvate dehydrogenase complex transcriptional repressor PdhR	NA	NA	NA	NA
WP_005314149.1\|441392_444053_+	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	NA	NA	NA	NA
WP_042468130.1\|444138_446010_+	pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase	NA	NA	NA	NA
WP_005314147.1\|446170_447598_+	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	2.7e-41	26.9
WP_042468131.1\|447727_448684_+	sensor domain-containing diguanylate cyclase	G3MA91	Bacillus_virus	5.0e-15	30.9
WP_005314145.1\|448680_448863_-	hypothetical protein	NA	NA	NA	NA
WP_042468132.1\|448998_450645_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.1e-17	61.3
WP_017411941.1\|450808_452719_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.0e-19	30.3
WP_005314141.1\|452977_455236_+	patatin-like phospholipase domain-containing protein	A0A1V0SFX9	Hokovirus	2.0e-06	27.4
WP_042468133.1\|455464_458062_+	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase	NA	NA	NA	NA
WP_042468134.1\|458394_459978_+	EAL domain-containing protein	NA	NA	NA	NA
WP_042468135.1\|460232_460982_-	3-oxoacyl-ACP reductase FabG	NA	NA	NA	NA
WP_042468136.1\|461158_462082_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_042468137.1\|462153_463065_-	LysR family transcriptional regulator	Q6JIH3	Burkholderia_virus	2.4e-14	27.0
WP_088814132.1\|463142_463760_+	LysE family transporter	NA	NA	NA	NA
WP_005314125.1\|463877_465272_+	FAD-binding protein	NA	NA	NA	NA
WP_088814347.1\|465352_466471_+	GTP-binding protein	NA	NA	NA	NA
WP_005314122.1\|467924_468413_-	YbaK/EbsC family protein	NA	NA	NA	NA
WP_005314121.1\|468537_469047_-	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_005314120.1\|469099_469471_-	dihydroneopterin aldolase	NA	NA	NA	NA
WP_011898298.1\|469640_470303_+	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_005314116.1\|470897_471230_-	hypothetical protein	NA	NA	NA	NA
WP_005314114.1\|471360_471876_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_005314112.1\|472337_472556_+	hypothetical protein	NA	NA	NA	NA
WP_005314110.1\|472568_473093_+	hypothetical protein	NA	NA	NA	NA
WP_005314108.1\|473112_473607_+	hypothetical protein	NA	NA	NA	NA
WP_005314106.1\|473673_474120_+	DUF2787 domain-containing protein	NA	NA	NA	NA
WP_076611341.1\|474584_475502_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|477644_478562_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005314088.1\|478842_479274_+	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_076611341.1\|481572_482490_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

855567 : 924504

Shigella_phage(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085941409.1\|855567_856729_+\|transposase	IS3-like element ISAs6 family transposase	Q716C2	Shigella_phage	2.8e-84	51.6
WP_005318620.1\|856935_859083_+	S9 family peptidase	A0A1V0SHT0	Klosneuvirus	1.8e-65	32.1
WP_157669187.1\|859171_859312_-	hypothetical protein	NA	NA	NA	NA
WP_042468997.1\|859298_861452_+	AsmA family protein	NA	NA	NA	NA
WP_005318627.1\|861626_862166_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_042468996.1\|862238_862973_+	SDR family oxidoreductase	A0A0M4JSW6	Mollivirus	4.7e-05	26.9
WP_076611341.1\|863957_864875_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|866037_866955_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005318643.1\|867228_867585_+	glucitol operon activator	NA	NA	NA	NA
WP_011899087.1\|867674_868439_+	DNA-binding transcriptional repressor	NA	NA	NA	NA
WP_088814148.1\|868673_871556_-	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	NA	NA	NA	NA
WP_005318651.1\|871798_872245_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_042468127.1\|872316_873471_-	chromate efflux transporter	NA	NA	NA	NA
WP_017411818.1\|873569_874013_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_042468126.1\|874214_875219_-	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_088814149.1\|875215_875692_-	organic hydroperoxide resistance protein	NA	NA	NA	NA
WP_005318661.1\|875805_876231_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_005318662.1\|876265_876493_+	hypothetical protein	NA	NA	NA	NA
WP_005318663.1\|876638_876956_+	hypothetical protein	NA	NA	NA	NA
WP_005318665.1\|877123_877600_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_005318667.1\|877908_878532_-	transcriptional regulator	NA	NA	NA	NA
WP_005318669.1\|878715_879954_+	MFS transporter	NA	NA	NA	NA
WP_017411815.1\|880094_880916_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_005318675.1\|881056_881620_-	DUF2799 domain-containing protein	NA	NA	NA	NA
WP_005318677.1\|881825_882665_+	isopenicillin N synthase family oxygenase	NA	NA	NA	NA
WP_088814150.1\|882878_884192_+	sodium-dependent transporter	NA	NA	NA	NA
WP_011899085.1\|884153_884921_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005318684.1\|885288_886602_+	sodium-dependent transporter	NA	NA	NA	NA
WP_011899084.1\|888384_889110_-	DUF3142 domain-containing protein	NA	NA	NA	NA
WP_042468123.1\|889079_891140_-	hypothetical protein	NA	NA	NA	NA
WP_005318694.1\|891251_891716_-	hypothetical protein	NA	NA	NA	NA
WP_042468122.1\|891783_893160_-	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_005318697.1\|893276_893873_+	LysE family translocator	NA	NA	NA	NA
WP_042468121.1\|893988_894579_+	LysE family translocator	NA	NA	NA	NA
WP_042468120.1\|894733_895432_+	aspartate/glutamate racemase family protein	NA	NA	NA	NA
WP_005318702.1\|895554_896661_+	acyltransferase	NA	NA	NA	NA
WP_005318704.1\|896963_897434_+	YhcH/YjgK/YiaL family protein	NA	NA	NA	NA
WP_005318706.1\|897651_898851_+	acetate kinase	NA	NA	NA	NA
WP_005318708.1\|898984_900235_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_042468119.1\|900412_901339_+	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_005318714.1\|901627_903148_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_076611341.1\|904147_905065_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468750.1\|905438_905708_-	hypothetical protein	NA	NA	NA	NA
WP_139403094.1\|906274_907090_-	hypothetical protein	NA	NA	NA	NA
WP_005318756.1\|907888_908743_-	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	NA	NA	NA	NA
WP_085941653.1\|908736_909180_-	DUF2390 domain-containing protein	NA	NA	NA	NA
WP_005318760.1\|909190_911101_-	ABC transporter ATP-binding protein	A0A2K9L3Z8	Tupanvirus	3.6e-73	33.0
WP_005318762.1\|911255_911666_+	CBS domain-containing protein	NA	NA	NA	NA
WP_005318764.1\|911744_912200_-	NfeD family protein	NA	NA	NA	NA
WP_005318765.1\|912196_913120_-	SPFH/Band 7/PHB domain protein	NA	NA	NA	NA
WP_042468753.1\|913383_914760_+	uroporphyrinogen-III C-methyltransferase	NA	NA	NA	NA
WP_005318769.1\|914891_915845_+	sulfate adenylyltransferase subunit CysD	NA	NA	NA	NA
WP_005318771.1\|915856_917272_+	sulfate adenylyltransferase subunit CysN	A0A1V0SGC3	Hokovirus	4.6e-33	28.5
WP_005318772.1\|917276_919001_+	SLC13 family permease	NA	NA	NA	NA
WP_005318774.1\|919172_919763_+	adenylyl-sulfate kinase	NA	NA	NA	NA
WP_088814343.1\|920150_921287_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_088814152.1\|921642_923181_-	NACHT domain-containing protein	NA	NA	NA	NA
WP_088814153.1\|923586_924504_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

973729 : 983653

uncultured_Mediterranean_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005318886.1\|973729_974476_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	9.7e-67	52.0
WP_005318888.1\|974480_975098_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	9.0e-34	46.4
WP_085941649.1\|975100_975664_+	DedA family protein	NA	NA	NA	NA
WP_005318892.1\|975673_976720_+	peptidoglycan DD-metalloendopeptidase family protein	A0A0A7NU10	Lactobacillus_phage	7.9e-14	41.3
WP_042467924.1\|976767_977751_+	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	7.6e-35	34.1
WP_005318896.1\|977836_978850_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.5e-107	58.0
WP_005309452.1\|979029_979245_+	30S ribosomal protein S21	NA	NA	NA	NA
WP_005318899.1\|979260_979704_+	GatB/YqeY domain-containing protein	A0A292GL36	Xanthomonas_phage	1.3e-26	47.9
WP_005318901.1\|979792_981580_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.4e-73	41.1
WP_080697382.1\|981793_983653_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-34	32.6

DBSCAN-SWA_6

1253177 : 1291278

Phage_21(25.0%)

integrase,transposase

attL 1264746:1264761|attR 1296977:1296992

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|1253177_1254095_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005312712.1\|1255767_1257129_-	MFS transporter	NA	NA	NA	NA
WP_005312708.1\|1257319_1258213_-	protoheme IX farnesyltransferase	NA	NA	NA	NA
WP_021138023.1\|1259176_1261153_-	cytochrome o ubiquinol oxidase subunit I	NA	NA	NA	NA
WP_011898946.1\|1261156_1262182_-	cytochrome o ubiquinol oxidase subunit II	NA	NA	NA	NA
WP_088814166.1\|1262790_1264716_+	NAD(P)-binding protein	NA	NA	NA	NA
WP_088814167.1\|1264712_1265912_+	cytochrome c	NA	NA	NA	NA
1264746:1264761	attL	NA	NA	NA	NA
WP_076611341.1\|1266172_1267090_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005312718.1\|1267836_1268940_-	YdcF family protein	NA	NA	NA	NA
WP_034283370.1\|1269220_1270441_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_005312724.1\|1270792_1271830_-	Mal regulon transcriptional regulator MalI	NA	NA	NA	NA
WP_005312727.1\|1272146_1273718_+	PTS maltose transporter subunit IICB	NA	NA	NA	NA
WP_076611341.1\|1274378_1275296_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814343.1\|1276197_1277334_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_005312736.1\|1278114_1278405_-	hypothetical protein	NA	NA	NA	NA
WP_042468934.1\|1278672_1280580_-	PTS fructose transporter subunit EIIC	NA	NA	NA	NA
WP_005312738.1\|1281288_1281444_+	hypothetical protein	NA	NA	NA	NA
WP_017412946.1\|1281672_1282872_-	mannose-6-phosphate isomerase, class I	NA	NA	NA	NA
WP_088822015.1\|1282989_1283880_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005312750.1\|1284081_1285335_+	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	2.1e-13	70.4
WP_005312753.1\|1285410_1285587_-	hypothetical protein	NA	NA	NA	NA
WP_088814108.1\|1285882_1286800_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005312795.1\|1286923_1287190_-	hypothetical protein	NA	NA	NA	NA
WP_005312798.1\|1287334_1287754_-	hypothetical protein	NA	NA	NA	NA
WP_005312801.1\|1287750_1288362_-	hypothetical protein	NA	NA	NA	NA
WP_026141826.1\|1288372_1288723_-	hypothetical protein	NA	NA	NA	NA
WP_005312807.1\|1288732_1288951_-	AlpA family transcriptional regulator	B7SYF9	Stenotrophomonas_phage	1.6e-09	50.0
WP_042468226.1\|1289062_1289914_-	hypothetical protein	A0A2H4JEC4	uncultured_Caudovirales_phage	2.0e-07	24.9
WP_088814169.1\|1290027_1291278_-\|integrase	tyrosine-type recombinase/integrase	A0A1V0E8G8	Vibrio_phage	2.8e-111	46.3
1296977:1296992	attR	NA	NA	NA	NA

DBSCAN-SWA_7

1389912 : 1453420

Planktothrix_phage(22.22%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005312177.1\|1389912_1390920_+\|protease	protease SohB	A0A2H4UUF9	Bodo_saltans_virus	2.3e-18	31.5
WP_005312179.1\|1391010_1392348_-	N-succinylarginine dihydrolase	NA	NA	NA	NA
WP_042467105.1\|1392709_1395331_+	type I DNA topoisomerase	E3T4K4	Cafeteria_roenbergensis_virus	1.6e-84	36.4
WP_011898984.1\|1395743_1396100_-	methylated-DNA--protein-cysteine methyltransferase	NA	NA	NA	NA
WP_017411763.1\|1396169_1397723_-	methyl-accepting chemotaxis protein	A0A1B0V854	Salmonella_phage	1.6e-34	41.6
WP_017411761.1\|1397937_1399803_-	family 20 glycosylhydrolase	A0A076G5S5	Staphylococcus_phage	4.7e-09	25.1
WP_005312200.1\|1399963_1400836_-	N-acetylglucosamine kinase	NA	NA	NA	NA
WP_042467101.1\|1400941_1402681_-	chitobiase	NA	NA	NA	NA
WP_042467100.1\|1402795_1403788_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.2e-17	33.7
WP_005312211.1\|1403799_1404819_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.7e-13	27.7
WP_042467099.1\|1404815_1405712_-	ABC transporter permease	NA	NA	NA	NA
WP_042467097.1\|1405713_1406697_-	ABC transporter permease	NA	NA	NA	NA
WP_042467095.1\|1406814_1408500_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005312229.1\|1412869_1413163_-	hypothetical protein	NA	NA	NA	NA
WP_005312232.1\|1413377_1413578_+	YbfA family protein	NA	NA	NA	NA
WP_005312235.1\|1413911_1414376_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_088814361.1\|1414666_1415935_+	PAS domain S-box protein	A0A2H4J162	uncultured_Caudovirales_phage	2.8e-13	40.3
WP_034282334.1\|1416013_1417387_+	HD domain-containing protein	NA	NA	NA	NA
WP_005312244.1\|1417455_1418514_-	FUSC family protein	NA	NA	NA	NA
WP_042467092.1\|1418577_1420323_-	bifunctional molybdopterin-guanine dinucleotide biosynthesis adaptor protein MobB/molybdopterin molybdotransferase MoeA	NA	NA	NA	NA
WP_005312249.1\|1420319_1420967_-	molybdenum cofactor guanylyltransferase MobA	NA	NA	NA	NA
WP_005312252.1\|1420938_1421634_-	energy-coupling factor ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.1e-11	29.1
WP_005312255.1\|1421749_1422451_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_011898980.1\|1422515_1423361_-	tungsten ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_042467088.1\|1424977_1427104_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_088814362.1\|1427228_1428089_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005312267.1\|1428110_1428968_-	formate dehydrogenase accessory sulfurtransferase FdhD	NA	NA	NA	NA
WP_088814179.1\|1429537_1430464_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814343.1\|1430559_1431696_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_088814180.1\|1431784_1432045_-	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|1432967_1433885_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814181.1\|1434369_1434798_-	toxin-antitoxin system YwqK family antitoxin	NA	NA	NA	NA
WP_088814343.1\|1435406_1436543_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_042468734.1\|1436934_1437525_+	DUF3305 domain-containing protein	NA	NA	NA	NA
WP_088814182.1\|1437517_1438117_+	DUF3306 domain-containing protein	NA	NA	NA	NA
WP_042468736.1\|1438220_1439966_+	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_042468737.1\|1439976_1440606_+	TorD family cytoplasmic chaperone	NA	NA	NA	NA
WP_042468738.1\|1440707_1440911_+	transcriptional initiation protein Tat	NA	NA	NA	NA
WP_088814183.1\|1440946_1443847_+	formate dehydrogenase subunit alpha	NA	NA	NA	NA
WP_042468739.1\|1443851_1444496_+	4Fe-4S dicluster domain-containing protein	A0A077SL61	Escherichia_phage	2.8e-14	30.2
WP_042468741.1\|1444492_1445446_+	formate dehydrogenase subunit gamma	NA	NA	NA	NA
WP_042468747.1\|1445479_1446244_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_021139102.1\|1446504_1448220_+	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_087756217.1\|1448560_1449856_+	uracil-xanthine permease	NA	NA	NA	NA
WP_042468743.1\|1450405_1451137_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_088814108.1\|1452502_1453420_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_8

1501682 : 1544488

Bacillus_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|1501682_1502600_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005298604.1\|1502872_1503139_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005316804.1\|1503343_1504705_+	sodium-dependent transporter	NA	NA	NA	NA
WP_011898481.1\|1504782_1505649_-	patatin-like phospholipase RssA	NA	NA	NA	NA
WP_088814363.1\|1505682_1506819_-	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	2.2e-22	34.6
WP_011898483.1\|1507239_1508301_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_042468845.1\|1508300_1511420_+	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	3.4e-81	24.4
WP_005316799.1\|1511514_1511886_+	hypothetical protein	NA	NA	NA	NA
WP_088814186.1\|1512012_1514439_+	YgiQ family radical SAM protein	M1QSD9	Pseudomonas_phage	1.7e-99	67.6
WP_011898484.1\|1514497_1514815_-	hypothetical protein	NA	NA	NA	NA
WP_157668953.1\|1514942_1515809_-	DUF4917 family protein	NA	NA	NA	NA
WP_011899080.1\|1515789_1516821_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_088814343.1\|1517024_1518161_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_017412842.1\|1520069_1520591_+	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_005316782.1\|1520938_1521625_+	aquaporin Z	NA	NA	NA	NA
WP_088814364.1\|1521691_1522447_-	transglycosylase SLT domain-containing protein	A0A0H3V0Q1	Geobacillus_virus	1.2e-27	57.7
WP_085941431.1\|1522608_1523970_-	alpha-amylase	NA	NA	NA	NA
WP_042468634.1\|1524198_1525362_-	M23 family metallopeptidase	NA	NA	NA	NA
WP_042468632.1\|1525835_1526276_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_088814188.1\|1526280_1526889_-	DUF1439 domain-containing protein	NA	NA	NA	NA
WP_042468630.1\|1526919_1528383_+	cardiolipin synthase	NA	NA	NA	NA
WP_005316767.1\|1528478_1529741_+	DUF945 family protein	NA	NA	NA	NA
WP_042468628.1\|1529810_1530647_-	formyltetrahydrofolate deformylase	M4QRX9	Synechococcus_phage	3.1e-13	37.1
WP_005316761.1\|1531120_1531774_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	2.3e-40	43.1
WP_005334342.1\|1531998_1532241_+	hypothetical protein	NA	NA	NA	NA
WP_005316757.1\|1532384_1533233_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_005316754.1\|1533229_1533952_-	4'-phosphopantetheinyl transferase superfamily protein	NA	NA	NA	NA
WP_087755208.1\|1534214_1534715_+	peptidase P60	A0A217EQL1	Bacillus_phage	1.4e-16	43.8
WP_034282620.1\|1534865_1535822_+	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	NA	NA	NA	NA
WP_005316745.1\|1536064_1536772_+	MaoC family dehydratase	NA	NA	NA	NA
WP_088814189.1\|1536908_1537895_-	DUF481 domain-containing protein	NA	NA	NA	NA
WP_005316739.1\|1537925_1538843_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_076611341.1\|1539334_1540252_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|1541912_1542830_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|1543570_1544488_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_9

1565063 : 1617296

Escherichia_phage(40.0%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|1565063_1565981_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_017412372.1\|1567889_1568408_+	flagellar basal body-associated protein FliL	NA	NA	NA	NA
WP_005319319.1\|1568417_1569488_+	flagellar motor switch protein FliM	NA	NA	NA	NA
WP_017412373.1\|1569537_1569930_+	flagellar motor switch protein FliN	NA	NA	NA	NA
WP_005319315.1\|1569991_1570375_+	flagellar biosynthetic protein FliO	NA	NA	NA	NA
WP_042468832.1\|1570361_1571141_+	flagellar type III secretion system pore protein FliP	NA	NA	NA	NA
WP_005319310.1\|1571168_1571438_+	flagellar biosynthesis protein FliQ	NA	NA	NA	NA
WP_042468835.1\|1571517_1572315_+	flagellar type III secretion system protein FliR	NA	NA	NA	NA
WP_042468830.1\|1572401_1573247_+	flagellar biosynthesis protein FlhB	NA	NA	NA	NA
WP_088814191.1\|1573354_1575457_+	flagellar biosynthesis protein FlhA	NA	NA	NA	NA
WP_005319300.1\|1575473_1576892_+	flagellar biosynthesis protein FlhF	NA	NA	NA	NA
WP_088814192.1\|1576899_1577733_+	MinD/ParA family protein	NA	NA	NA	NA
WP_005319297.1\|1577761_1578481_+	RNA polymerase sigma factor FliA	NA	NA	NA	NA
WP_005319295.1\|1578592_1578976_+	chemotaxis protein CheY	Q56AR1	Bacillus_thuringiensis_phage	4.4e-07	32.8
WP_088814193.1\|1578988_1579720_+	protein phosphatase CheZ	NA	NA	NA	NA
WP_011899080.1\|1579735_1580767_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_042469000.1\|1580926_1581529_+	peroxiredoxin C	NA	NA	NA	NA
WP_005313085.1\|1581675_1582641_-	alpha-L-glutamate ligase-like protein	NA	NA	NA	NA
WP_088814194.1\|1582644_1584183_-	inactive transglutaminase family protein	NA	NA	NA	NA
WP_085941630.1\|1584186_1584903_-\|protease	ATP-dependent zinc protease	NA	NA	NA	NA
WP_005313094.1\|1585027_1586005_-\|tRNA	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	NA	NA	NA	NA
WP_005313097.1\|1586008_1586752_-	carboxy-S-adenosyl-L-methionine synthase CmoA	NA	NA	NA	NA
WP_088814108.1\|1587704_1588622_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468944.1\|1589379_1591146_+\|tRNA	aspartate--tRNA ligase	NA	NA	NA	NA
WP_005313105.1\|1591238_1591979_+	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_042468945.1\|1592383_1594009_+	phosphoethanolamine--lipid A transferase	NA	NA	NA	NA
WP_042468948.1\|1594239_1596672_-	family 20 glycosylhydrolase	NA	NA	NA	NA
WP_076611341.1\|1596818_1597736_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814197.1\|1597760_1598339_+	acyl carrier protein	NA	NA	NA	NA
WP_080697436.1\|1598335_1599154_+	hypothetical protein	NA	NA	NA	NA
WP_157668954.1\|1599129_1599264_+	hypothetical protein	NA	NA	NA	NA
WP_088814198.1\|1599293_1601948_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	4.1e-59	25.6
WP_157668955.1\|1601926_1602052_+	hypothetical protein	NA	NA	NA	NA
WP_088814199.1\|1603011_1603929_-\|transposase	IS5-like element ISAs4 family transposase	Q9MCT5	Escherichia_phage	5.7e-93	55.5
WP_088814200.1\|1604613_1605764_-\|transposase	IS3-like element ISAs32 family transposase	U5P429	Shigella_phage	9.0e-96	63.1
WP_085941483.1\|1606511_1607789_-	ROK family protein	NA	NA	NA	NA
WP_005309677.1\|1607730_1608876_-	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_088814201.1\|1608885_1609686_-	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_076611341.1\|1611532_1612450_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042467528.1\|1612623_1615287_+	family 20 glycosylhydrolase	NA	NA	NA	NA
WP_005309688.1\|1615634_1617296_+\|tRNA	glutamine--tRNA ligase	A0A222YZ70	Escherichia_phage	7.8e-266	79.5

DBSCAN-SWA_10

1872938 : 1949750

Vibrio_phage(18.18%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088814368.1\|1872938_1874075_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_157668957.1\|1874279_1875116_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|1875925_1876843_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005314700.1\|1877522_1878458_+	TIGR01212 family radical SAM protein	NA	NA	NA	NA
WP_005314720.1\|1878875_1881020_+	type I secretion system permease/ATPase	F2Y2R6	Organic_Lake_phycodnavirus	6.3e-26	33.9
WP_017412894.1\|1881012_1882431_+	HlyD family type I secretion periplasmic adaptor subunit	NA	NA	NA	NA
WP_005314727.1\|1882466_1883792_+	TolC family outer membrane protein	NA	NA	NA	NA
WP_005314730.1\|1883913_1884675_+	hypothetical protein	NA	NA	NA	NA
WP_005314739.1\|1884678_1886604_+	EAL domain-containing protein	NA	NA	NA	NA
WP_042468733.1\|1888321_1891795_+	type I secretion C-terminal target domain-containing protein	NA	NA	NA	NA
WP_042468729.1\|1891881_1892439_+	hypothetical protein	NA	NA	NA	NA
WP_088814209.1\|1892480_1893182_+	DUF541 domain-containing protein	NA	NA	NA	NA
WP_088814210.1\|1893292_1894455_-\|transposase	IS3-like element ISAs33 family transposase	Q716C2	Shigella_phage	2.8e-84	50.8
WP_042468638.1\|1894564_1895572_+	hypothetical protein	NA	NA	NA	NA
WP_005314771.1\|1897981_1898161_-	hypothetical protein	NA	NA	NA	NA
WP_042468640.1\|1898514_1899708_+	trans-2-enoyl-CoA reductase family protein	NA	NA	NA	NA
WP_042468642.1\|1899870_1901346_+	YfcC family protein	NA	NA	NA	NA
WP_005314784.1\|1901410_1902625_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_005314787.1\|1903017_1903230_+	DUF1653 domain-containing protein	NA	NA	NA	NA
WP_005314790.1\|1903291_1903555_-	GrxA family glutaredoxin	A0A2I7SAE2	Vibrio_phage	6.1e-24	62.8
WP_042468643.1\|1903752_1905198_-	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_042468644.1\|1905303_1907064_-	DEAD/DEAH box helicase	M4Q3N1	Vibrio_phage	1.9e-92	40.9
WP_005314797.1\|1907165_1908203_-	HlyD family secretion protein	NA	NA	NA	NA
WP_005314799.1\|1908206_1908545_-	DUF3302 domain-containing protein	NA	NA	NA	NA
WP_042468645.1\|1908833_1910255_-	carbon starvation protein A	NA	NA	NA	NA
WP_005314806.1\|1910397_1911102_-	two-component system response regulator BtsR	NA	NA	NA	NA
WP_005314809.1\|1911177_1912854_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	8.4e-159	55.9
WP_076611341.1\|1913787_1914705_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005314815.1\|1915624_1918300_-	bifunctional acetaldehyde-CoA/alcohol dehydrogenase	NA	NA	NA	NA
WP_085941443.1\|1918595_1919324_-	2OG-Fe dioxygenase family protein	NA	NA	NA	NA
WP_005314822.1\|1919496_1920132_+	YchE family NAAT transporter	NA	NA	NA	NA
WP_042468196.1\|1920414_1922034_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_021139963.1\|1922132_1923053_+	oligopeptide ABC transporter permease OppB	NA	NA	NA	NA
WP_005314829.1\|1923067_1923979_+	oligopeptide ABC transporter permease OppC	NA	NA	NA	NA
WP_005314832.1\|1924011_1924998_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.4e-15	31.7
WP_005314835.1\|1924994_1925108_+	hypothetical protein	NA	NA	NA	NA
WP_042468189.1\|1925108_1926104_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-19	31.9
WP_034282953.1\|1926406_1927351_+	TerC family protein	A0A291LBC5	Escherichia_phage	9.2e-38	36.3
WP_005314845.1\|1927429_1928656_-	alanine racemase	NA	NA	NA	NA
WP_005314849.1\|1928847_1929288_+	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_011898617.1\|1929369_1930629_-	dicarboxylate/amino acid:cation symporter	NA	NA	NA	NA
WP_042468190.1\|1930835_1931402_-	hypothetical protein	NA	NA	NA	NA
WP_005314854.1\|1931821_1933165_-	dihydroorotase	NA	NA	NA	NA
WP_085941594.1\|1933310_1934120_+	hypothetical protein	NA	NA	NA	NA
WP_088814211.1\|1934191_1936357_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	7.3e-30	40.1
WP_005314859.1\|1936454_1936805_+	purine nucleoside phosphoramidase	NA	NA	NA	NA
WP_088814369.1\|1936882_1938235_+	hypothetical protein	NA	NA	NA	NA
WP_005314863.1\|1938309_1938708_+	DUF1425 domain-containing protein	NA	NA	NA	NA
WP_005314873.1\|1938707_1939304_+	penicillin-binding protein activator LpoB	NA	NA	NA	NA
WP_042468193.1\|1939293_1940127_+	phosphotransferase	NA	NA	NA	NA
WP_005314875.1\|1940130_1940988_+	hypothetical protein	NA	NA	NA	NA
WP_085941445.1\|1941059_1941572_+	hypothetical protein	NA	NA	NA	NA
WP_042468194.1\|1941730_1943533_+	protein translocase subunit SecD	NA	NA	NA	NA
WP_005314878.1\|1943646_1944552_+	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	2.0e-34	35.2
WP_011898624.1\|1944926_1946546_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	2.5e-14	48.1
WP_076611341.1\|1947362_1948280_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814343.1\|1948613_1949750_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA

DBSCAN-SWA_11

1984199 : 2016540

Bacillus_virus(14.29%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088814214.1\|1984199_1985231_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_042468681.1\|1985274_1987212_+	EAL domain-containing protein	G3MA91	Bacillus_virus	6.3e-17	32.1
WP_088814215.1\|1987302_1988028_+	oxygen-insensitive NADPH nitroreductase	NA	NA	NA	NA
WP_005315024.1\|1988217_1988982_+	hypothetical protein	NA	NA	NA	NA
WP_085941598.1\|1988984_1989530_+	hypothetical protein	NA	NA	NA	NA
WP_005315028.1\|1989574_1990783_-	MFS transporter	NA	NA	NA	NA
WP_042468679.1\|1990876_1991752_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_005315034.1\|1991825_1992800_+	HTH-type transcriptional regulator CysB	NA	NA	NA	NA
WP_005315038.1\|1992945_1993539_-	GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.3e-42	46.5
WP_005315040.1\|1993787_1994480_+	(d)CMP kinase	NA	NA	NA	NA
WP_005315043.1\|1994574_1996245_+	30S ribosomal protein S1	NA	NA	NA	NA
WP_042468678.1\|1996337_1996622_+	integration host factor subunit beta	A0A0H3UZA0	Geobacillus_virus	4.4e-12	38.9
WP_005315045.1\|1996778_1997063_+	DUF1049 domain-containing protein	NA	NA	NA	NA
WP_005315046.1\|1997072_1998239_+	lipopolysaccharide assembly protein LapB	NA	NA	NA	NA
WP_005315048.1\|1998349_1999051_+	orotidine-5'-phosphate decarboxylase	NA	NA	NA	NA
WP_005315050.1\|1999124_1999682_-	rhombosortase	NA	NA	NA	NA
WP_085941447.1\|1999632_2000322_+	DTW domain-containing protein	NA	NA	NA	NA
WP_034282960.1\|2000345_2001053_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	2.9e-84	67.1
WP_085941448.1\|2001072_2001786_+	7-carboxy-7-deazaguanine synthase QueE	A0A2I7S8X1	Vibrio_phage	1.4e-17	39.4
WP_005315061.1\|2001787_2002018_+	DUF3820 family protein	NA	NA	NA	NA
WP_042468675.1\|2002014_2002578_+	cob(I)yrinic acid a,c-diamide adenosyltransferase	NA	NA	NA	NA
WP_005315078.1\|2002644_2003052_-	H-NS histone family protein	NA	NA	NA	NA
WP_076611341.1\|2003212_2004130_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814214.1\|2004307_2005339_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_005315093.1\|2005860_2007441_+	Na+/H+ antiporter NhaC family protein	NA	NA	NA	NA
WP_005315094.1\|2007545_2008127_+	thymidine kinase	A0A0F6TIQ8	Escherichia_coli_O157_typing_phage	1.6e-48	52.7
WP_005315095.1\|2008186_2009524_-	flavohemoglobin expression-modulating QEGLA motif protein	NA	NA	NA	NA
WP_011898640.1\|2009676_2010138_+	YbjN domain-containing protein	NA	NA	NA	NA
WP_005315097.1\|2010904_2012008_-	alanine racemase	A0A0P0YM39	Yellowstone_lake_mimivirus	7.5e-31	31.1
WP_088814217.1\|2012313_2013261_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|2013285_2014203_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_157668958.1\|2015286_2015508_+	hypothetical protein	NA	NA	NA	NA
WP_088814371.1\|2015403_2016540_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA

DBSCAN-SWA_12

2035888 : 2202804

117

Tupanvirus(13.64%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005315148.1\|2035888_2037358_-\|tRNA	L-seryl-tRNA(Sec) selenium transferase	NA	NA	NA	NA
WP_005315151.1\|2037930_2038422_-	hydrogenase maturation peptidase HycI	NA	NA	NA	NA
WP_005315153.1\|2038421_2038835_-	HycH family protein	NA	NA	NA	NA
WP_005315156.1\|2038827_2039643_-	NADH-quinone oxidoreductase subunit B family protein	NA	NA	NA	NA
WP_042468239.1\|2039642_2040200_-	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_005315165.1\|2040209_2041928_-	hydrogenase large subunit	NA	NA	NA	NA
WP_011898650.1\|2042007_2042961_-	hydrogenase 3 membrane subunit	NA	NA	NA	NA
WP_042468238.1\|2042962_2044846_-	hydrogenase 4 subunit B	NA	NA	NA	NA
WP_042468237.1\|2044845_2045541_-	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_157668975.1\|2046077_2047823_-	low affinity potassium transporter Kup	A7J6G4	Paramecium_bursaria_Chlorella_virus	7.4e-57	29.2
WP_076611341.1\|2047912_2048830_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_080697430.1\|2049504_2052234_-	hypothetical protein	NA	NA	NA	NA
WP_005315180.1\|2052475_2052787_-	hypothetical protein	NA	NA	NA	NA
WP_080697431.1\|2054117_2056262_+	formate dehydrogenase subunit alpha	NA	NA	NA	NA
WP_076611341.1\|2056434_2057352_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468803.1\|2057844_2059959_+	GAF domain-containing protein	NA	NA	NA	NA
WP_005315205.1\|2059971_2060796_+	formate dehydrogenase accessory sulfurtransferase FdhD	NA	NA	NA	NA
WP_005315214.1\|2060991_2061594_+	recombination protein RecR	NA	NA	NA	NA
WP_005315218.1\|2061811_2063725_+	molecular chaperone HtpG	A0A1B1ISV4	uncultured_Mediterranean_phage	4.5e-116	36.5
WP_005315220.1\|2063741_2063936_+	hypothetical protein	NA	NA	NA	NA
WP_017412939.1\|2063982_2064627_+	adenylate kinase	NA	NA	NA	NA
WP_080697425.1\|2064678_2065707_+	ferrochelatase	NA	NA	NA	NA
WP_021139169.1\|2065778_2066171_+	hypothetical protein	NA	NA	NA	NA
WP_042468808.1\|2066357_2067662_+	inosine/guanosine kinase	NA	NA	NA	NA
WP_100224073.1\|2067658_2069452_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	2.5e-23	38.0
WP_005315249.1\|2069565_2069928_+	DUF2750 domain-containing protein	NA	NA	NA	NA
WP_005315253.1\|2070108_2070603_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|2071351_2072269_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|2074835_2075753_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005315258.1\|2075923_2077924_-	hypothetical protein	NA	NA	NA	NA
WP_005315260.1\|2078070_2078622_-	lipoprotein	NA	NA	NA	NA
WP_034282536.1\|2078946_2080140_+	isochorismate synthase	NA	NA	NA	NA
WP_042468075.1\|2080136_2081807_+	(2,3-dihydroxybenzoyl)adenylate synthase	NA	NA	NA	NA
WP_005315266.1\|2081831_2082740_+	isochorismatase family protein	NA	NA	NA	NA
WP_042468074.1\|2082736_2085826_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	9.1e-42	25.2
WP_005315268.1\|2085855_2086605_+	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase	NA	NA	NA	NA
WP_042468073.1\|2086613_2092850_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	2.0e-72	24.4
WP_005315275.1\|2094528_2095473_-	amonabactin ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005315278.1\|2095631_2096357_+	amonabactin biosynthesis phosphopantetheinyl transferase AmoD	NA	NA	NA	NA
WP_017412316.1\|2096415_2097231_-	amonabactin ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.3e-13	25.3
WP_011898657.1\|2097230_2098298_-	amonabactin ABC transporter permease subunit 1	NA	NA	NA	NA
WP_005315288.1\|2098312_2099329_-	amonabactin ABC transporter permease subunit 2	NA	NA	NA	NA
WP_042468072.1\|2099399_2101373_-	siderophore amonabactin TonB-dependent receptor	A0A0P0I887	Acinetobacter_phage	2.4e-16	34.9
WP_042468071.1\|2101430_2102669_-	siderophore amonabactin export MFS transporter	NA	NA	NA	NA
WP_042468070.1\|2102925_2103678_+	hypothetical protein	NA	NA	NA	NA
WP_017412312.1\|2103693_2104155_-	DUF2919 domain-containing protein	NA	NA	NA	NA
WP_005315297.1\|2104306_2105254_-	magnesium/cobalt transporter CorA	NA	NA	NA	NA
WP_100766231.1\|2105604_2105697_-	hypothetical protein	NA	NA	NA	NA
WP_005315298.1\|2105709_2107359_-	electron transfer flavoprotein-ubiquinone oxidoreductase	NA	NA	NA	NA
WP_085941450.1\|2107476_2108238_+	electron transfer flavoprotein subunit beta/FixA family protein	NA	NA	NA	NA
WP_042468069.1\|2108332_2109262_+	electron transfer flavoprotein subunit alpha	NA	NA	NA	NA
WP_042468068.1\|2109486_2110575_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	5.0e-88	46.9
WP_005315305.1\|2110745_2112029_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_005315306.1\|2112257_2113313_+	3-deoxy-7-phosphoheptulonate synthase AroG	A0A0B6VT43	Edwardsiella_phage	5.2e-82	48.9
WP_088814220.1\|2113406_2115017_-	HAMP domain-containing protein	A0A2H4J162	uncultured_Caudovirales_phage	1.6e-26	40.8
WP_005315308.1\|2115264_2116632_+	heme anaerobic degradation radical SAM methyltransferase ChuW/HutW	NA	NA	NA	NA
WP_005315309.1\|2116696_2118067_-	exodeoxyribonuclease VII large subunit	A0A2H4UVM9	Bodo_saltans_virus	5.3e-34	36.7
WP_076611341.1\|2118766_2119684_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814343.1\|2120130_2121267_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_042469137.1\|2121564_2121987_-	biopolymer transporter ExbD	NA	NA	NA	NA
WP_017412973.1\|2121986_2122739_-	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_005315328.1\|2122741_2123491_-	energy transducer TonB	NA	NA	NA	NA
WP_088814108.1\|2123984_2124902_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_017412971.1\|2125446_2126910_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	5.3e-93	39.6
WP_005315336.1\|2126993_2128574_+	glutamine-hydrolyzing GMP synthase	NA	NA	NA	NA
WP_088814221.1\|2128967_2129207_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|2129251_2130169_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814123.1\|2131095_2132013_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814222.1\|2133637_2134555_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_085044777.1\|2134655_2135594_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_157669188.1\|2135652_2137233_+	hypothetical protein	NA	NA	NA	NA
WP_005315340.1\|2137537_2138911_+	protein kinase	NA	NA	NA	NA
WP_042467896.1\|2139134_2139782_+	thiopurine S-methyltransferase	NA	NA	NA	NA
WP_017411860.1\|2143021_2143489_+	phosphohistidine phosphatase SixA	NA	NA	NA	NA
WP_005315346.1\|2143622_2143829_+	DUF1107 domain-containing protein	NA	NA	NA	NA
WP_005315348.1\|2144029_2144950_+	DMT family transporter	NA	NA	NA	NA
WP_042467895.1\|2144997_2146614_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005315352.1\|2146997_2148032_+	class 1 fructose-bisphosphatase	A0A1V0SKX4	Klosneuvirus	4.2e-76	46.5
WP_005315354.1\|2148120_2151585_-	transcription-repair coupling factor	NA	NA	NA	NA
WP_005315356.1\|2151594_2152170_-	PilZ domain-containing protein	NA	NA	NA	NA
WP_088814223.1\|2152246_2153482_+	lipoprotein-releasing ABC transporter permease subunit	NA	NA	NA	NA
WP_087755599.1\|2153474_2154236_+	lipoprotein-releasing ABC transporter ATP-binding protein LolD	G9BWD6	Planktothrix_phage	2.0e-35	42.1
WP_005315361.1\|2154235_2155477_+	lipoprotein-releasing ABC transporter permease subunit LolE	NA	NA	NA	NA
WP_005315363.1\|2155564_2156155_-	5'-deoxynucleotidase	NA	NA	NA	NA
WP_011898663.1\|2156251_2156686_-	YccF domain-containing protein	NA	NA	NA	NA
WP_005315366.1\|2157114_2158425_+	trigger factor	NA	NA	NA	NA
WP_085941601.1\|2158532_2159135_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	5.4e-60	61.5
WP_017411865.1\|2159263_2160538_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	9.6e-131	57.5
WP_021140372.1\|2160679_2163034_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	3.6e-224	53.0
WP_005315375.1\|2163274_2163547_+	DNA-binding protein HU-beta	A7KV42	Bacillus_phage	5.0e-21	61.8
WP_088814373.1\|2163701_2165612_+	peptidylprolyl isomerase	NA	NA	NA	NA
WP_005315379.1\|2165870_2167463_-	ABC-F family ATPase	A0A2K9L0W2	Tupanvirus	1.1e-56	27.4
WP_042467894.1\|2167699_2169355_-	cation acetate symporter	NA	NA	NA	NA
WP_005315383.1\|2169351_2169663_-	DUF485 domain-containing protein	NA	NA	NA	NA
WP_005315390.1\|2169771_2170398_-	3'-5' exonuclease	NA	NA	NA	NA
WP_088814224.1\|2170400_2172188_-	cyclic nucleotide-binding/CBS domain-containing protein	NA	NA	NA	NA
WP_088814225.1\|2172370_2173177_+	crotonase/enoyl-CoA hydratase family protein	NA	NA	NA	NA
WP_088814226.1\|2173256_2174756_-	alanine:cation symporter family protein	NA	NA	NA	NA
WP_005315396.1\|2175056_2175494_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_005315399.1\|2176408_2177005_-	hypothetical protein	NA	NA	NA	NA
WP_042467892.1\|2177682_2180574_-	DUF748 domain-containing protein	NA	NA	NA	NA
WP_058406839.1\|2180622_2181384_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_005315403.1\|2181421_2181832_-	MerR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_005315404.1\|2181846_2182785_-	hydroxymethylglutaryl-CoA lyase	A0A1V0SKU2	Klosneuvirus	4.2e-43	35.7
WP_088814227.1\|2182799_2184785_-	biotin/lipoyl-binding protein	NA	NA	NA	NA
WP_042467890.1\|2184888_2185728_-	crotonase	NA	NA	NA	NA
WP_005315410.1\|2185738_2187358_-	methylcrotonoyl-CoA carboxylase	A0A1B2ITV7	Pike_perch_iridovirus	1.5e-19	53.4
WP_076611341.1\|2188338_2189256_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468863.1\|2189826_2191338_+	CoA-acylating methylmalonate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_088814229.1\|2191393_2192593_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_017412304.1\|2192741_2193539_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_005315425.1\|2193531_2194644_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_042468866.1\|2194721_2195642_+	3-hydroxyisobutyrate dehydrogenase	NA	NA	NA	NA
WP_042468868.1\|2195711_2196473_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	7.5e-06	24.2
WP_017412302.1\|2196861_2198298_+	arginine-ornithine antiporter	NA	NA	NA	NA
WP_005315438.1\|2198389_2199178_+	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_011899080.1\|2201772_2202804_+\|transposase	IS630 family transposase	NA	NA	NA	NA

DBSCAN-SWA_13

2456013 : 2517572

Synechococcus_phage(33.33%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088814108.1\|2456013_2456931_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814240.1\|2457065_2457191_+	hypothetical protein	NA	NA	NA	NA
WP_085941460.1\|2457316_2458012_-	FMN-dependent NADH-azoreductase	NA	NA	NA	NA
WP_042468359.1\|2458130_2459021_+	DMT family transporter	NA	NA	NA	NA
WP_042468362.1\|2459108_2460287_+	formate-dependent phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_017412079.1\|2460393_2461053_+	hexitol phosphatase HxpB	NA	NA	NA	NA
WP_017412080.1\|2461201_2461405_+	CPXCG motif-containing cysteine-rich protein	NA	NA	NA	NA
WP_005311235.1\|2461488_2462106_-	riboflavin synthase	NA	NA	NA	NA
WP_005311233.1\|2462236_2462443_+	YaeP family protein	NA	NA	NA	NA
WP_005311230.1\|2462595_2463948_+	MATE family efflux transporter	NA	NA	NA	NA
WP_080697413.1\|2463970_2464969_+	DUF3080 family protein	NA	NA	NA	NA
WP_085941613.1\|2465777_2468195_-	DNA polymerase II	L7TKF2	Halovirus	4.8e-30	27.0
WP_005311224.1\|2468383_2468875_+\|tRNA	prolyl-tRNA synthetase associated domain-containing protein	NA	NA	NA	NA
WP_011898751.1\|2470299_2470815_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_005311220.1\|2470911_2471772_-	serine/threonine protein kinase	NA	NA	NA	NA
WP_088814380.1\|2473074_2474064_-	lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase	NA	NA	NA	NA
WP_017412087.1\|2474338_2475331_-	TDT family transporter	NA	NA	NA	NA
WP_017412088.1\|2475430_2476360_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_088814381.1\|2476430_2477417_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_005311209.1\|2477450_2478296_-	deoxyribonuclease IV	A0A1V0SCI4	Indivirus	2.8e-17	25.9
WP_042468367.1\|2478450_2479383_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_042468368.1\|2479513_2480272_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_042468370.1\|2480360_2481797_-	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	2.5e-47	28.4
WP_042468371.1\|2481954_2482833_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_011899080.1\|2482852_2483884_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_088814222.1\|2484238_2485156_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468622.1\|2486745_2486934_-	hypothetical protein	NA	NA	NA	NA
WP_005311197.1\|2487425_2487968_+	glycine zipper 2TM domain-containing protein	NA	NA	NA	NA
WP_005311193.1\|2491969_2492149_+	hypothetical protein	NA	NA	NA	NA
WP_042468620.1\|2492210_2493317_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005311189.1\|2493435_2494488_+	iron ABC transporter permease	NA	NA	NA	NA
WP_005311187.1\|2494480_2495248_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.6e-11	24.5
WP_042468619.1\|2495321_2496551_+	MFS transporter	NA	NA	NA	NA
WP_021139313.1\|2496592_2497477_-	AEC family transporter	NA	NA	NA	NA
WP_085941462.1\|2497489_2498158_-	YaeQ family protein	NA	NA	NA	NA
WP_005301193.1\|2498336_2498477_-	TIGR02808 family protein	NA	NA	NA	NA
WP_005311174.1\|2498924_2499032_+	hypothetical protein	NA	NA	NA	NA
WP_042468618.1\|2500355_2501663_+	permease	NA	NA	NA	NA
WP_005311168.1\|2501724_2502630_-	PhzF family phenazine biosynthesis protein	NA	NA	NA	NA
WP_017413048.1\|2502906_2503110_+	hypothetical protein	NA	NA	NA	NA
WP_017413049.1\|2503188_2504028_-	hypothetical protein	NA	NA	NA	NA
WP_017413050.1\|2504081_2504585_-	peptide deformylase	E3SLL2	Synechococcus_phage	1.1e-13	35.2
WP_011898763.1\|2505011_2505323_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_076611341.1\|2505448_2506366_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005311149.1\|2506715_2507228_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_076611341.1\|2507422_2508340_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_085941615.1\|2508511_2508889_-	septal ring lytic transglycosylase RlpA family protein	F5B3X9	Synechococcus_phage	1.1e-15	52.5
WP_005311144.1\|2509141_2513569_-	chromosome partition protein MukB	NA	NA	NA	NA
WP_005311141.1\|2513596_2514334_-	chromosome partition protein MukE	NA	NA	NA	NA
WP_005311139.1\|2514314_2515649_-	chromosome partition protein MukF	NA	NA	NA	NA
WP_005311137.1\|2515742_2516519_-\|tRNA	tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM	NA	NA	NA	NA
WP_076611341.1\|2516654_2517572_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_14

2692599 : 2806613

Planktothrix_phage(14.29%)

plate,transposase,protease,bacteriocin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|2692599_2693517_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042469099.1\|2694166_2695366_-	cellulase family glycosylhydrolase	NA	NA	NA	NA
WP_005310858.1\|2695384_2696236_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_076611341.1\|2696816_2697734_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|2698353_2699271_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_017412380.1\|2700323_2701406_+	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	G9BWD6	Planktothrix_phage	3.0e-24	34.3
WP_005310852.1\|2701508_2701817_-	hypothetical protein	NA	NA	NA	NA
WP_052521837.1\|2702389_2703829_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	5.2e-24	25.1
WP_005310846.1\|2703885_2704308_+	hypothetical protein	NA	NA	NA	NA
WP_088814254.1\|2704469_2705474_+	cellulase family glycosylhydrolase	NA	NA	NA	NA
WP_005310842.1\|2705536_2706682_-	arabinogalactan endo-1,4-beta-galactosidase	NA	NA	NA	NA
WP_088814255.1\|2706750_2708043_-	maltoporin	NA	NA	NA	NA
WP_005310836.1\|2708527_2709529_-	HTH-type transcriptional regulator GalR	C6ZCU4	Enterobacteria_phage	1.8e-23	28.5
WP_080697401.1\|2709838_2710861_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	1.6e-80	45.3
WP_076611341.1\|2711755_2712673_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_011898809.1\|2713008_2714166_+	galactokinase	NA	NA	NA	NA
WP_005310828.1\|2714443_2715355_-	arabinose operon transcriptional regulator AraC	NA	NA	NA	NA
WP_017412388.1\|2715507_2716509_-	L-arabinose ABC transporter permease AraH	NA	NA	NA	NA
WP_042468202.1\|2716559_2718059_-	L-arabinose ABC transporter ATP-binding protein AraG	A0A2H4PQG7	Staphylococcus_phage	7.8e-15	27.4
WP_088814256.1\|2718134_2719127_-	arabinose ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_042468203.1\|2719488_2721180_+	ribulokinase	NA	NA	NA	NA
WP_005310818.1\|2721176_2721875_+	L-ribulose-5-phosphate 4-epimerase	NA	NA	NA	NA
WP_005310816.1\|2721895_2723395_+	L-arabinose isomerase	NA	NA	NA	NA
WP_005310814.1\|2723506_2724397_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_042468204.1\|2724510_2725662_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_042468205.1\|2725670_2726504_+	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_005310806.1\|2726549_2727320_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_042468206.1\|2727607_2728510_+	NERD domain-containing protein	NA	NA	NA	NA
WP_005310802.1\|2728665_2730093_+	exodeoxyribonuclease I	NA	NA	NA	NA
WP_005310800.1\|2730245_2730752_+	hypothetical protein	NA	NA	NA	NA
WP_017411675.1\|2730835_2732545_-	alpha-galactosidase	NA	NA	NA	NA
WP_076611341.1\|2732602_2733520_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005310798.1\|2733816_2734173_+	murein hydrolase regulator LrgA	NA	NA	NA	NA
WP_005310796.1\|2734169_2734856_+	membrane protein	NA	NA	NA	NA
WP_005310793.1\|2735044_2735926_+	cytidine deaminase	NA	NA	NA	NA
WP_005310791.1\|2736004_2737669_-	AMP-binding protein	A0A1V0SBX8	Catovirus	9.5e-46	28.4
WP_005310789.1\|2737766_2738045_-	YfcL family protein	NA	NA	NA	NA
WP_005310787.1\|2738168_2739284_-	ATP-NAD kinase family protein	NA	NA	NA	NA
WP_005310785.1\|2739394_2740126_+	TerC family protein	A0A0R6PEZ3	Moraxella_phage	1.1e-46	52.5
WP_017411676.1\|2740185_2740674_-	OmpA family protein	NA	NA	NA	NA
WP_005310780.1\|2740748_2741945_-	diguanylate cyclase	NA	NA	NA	NA
WP_005310778.1\|2741941_2742493_-	YfiR family protein	NA	NA	NA	NA
WP_005310776.1\|2742690_2744238_-	transcriptional regulator TyrR	NA	NA	NA	NA
WP_005310774.1\|2744372_2744726_-	4a-hydroxytetrahydrobiopterin dehydratase	NA	NA	NA	NA
WP_005310772.1\|2744779_2745574_-	phenylalanine 4-monooxygenase	NA	NA	NA	NA
WP_042467884.1\|2745743_2746787_-	TIGR01620 family protein	NA	NA	NA	NA
WP_005310768.1\|2746855_2748262_-	YcjX family protein	NA	NA	NA	NA
WP_085941469.1\|2748393_2748813_-	envelope stress response membrane protein PspC	NA	NA	NA	NA
WP_005310764.1\|2748794_2749031_-	envelope stress response membrane protein PspB	NA	NA	NA	NA
WP_042467881.1\|2749034_2749715_-	phage shock protein PspA	NA	NA	NA	NA
WP_005310760.1\|2749910_2750945_+	phage shock protein operon transcriptional activator	NA	NA	NA	NA
WP_085941622.1\|2751157_2752723_+	peptide ABC transporter substrate-binding protein SapA	NA	NA	NA	NA
WP_042467879.1\|2752725_2753685_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_005310755.1\|2753668_2754562_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_042467877.1\|2754561_2755560_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.5e-09	28.3
WP_005310752.1\|2755594_2756380_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.4e-17	29.6
WP_042467876.1\|2756536_2757295_-\|tRNA	tRNA hydroxylase	NA	NA	NA	NA
WP_005310748.1\|2757518_2759039_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.2e-87	42.4
WP_005310746.1\|2759060_2759549_-\|bacteriocin	bacteriocin production protein	NA	NA	NA	NA
WP_005310745.1\|2759736_2761032_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	7.5e-91	43.0
WP_017411682.1\|2761388_2762732_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	3.4e-78	41.2
WP_042467874.1\|2762850_2763459_-	outer membrane lipoprotein chaperone LolA	NA	NA	NA	NA
WP_042467873.1\|2763536_2766062_-	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	7.3e-90	49.6
WP_005300047.1\|2766264_2766756_-	leucine-responsive transcriptional regulator Lrp	NA	NA	NA	NA
WP_073536599.1\|2767420_2767612_+	hypothetical protein	NA	NA	NA	NA
WP_005310734.1\|2767830_2768781_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	9.5e-59	42.8
WP_005310731.1\|2770188_2770659_-	glycine zipper 2TM domain-containing protein	NA	NA	NA	NA
WP_005310730.1\|2770678_2771386_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_042467872.1\|2771382_2772099_+	arginyltransferase	NA	NA	NA	NA
WP_005300033.1\|2772167_2772386_+	translation initiation factor IF-1	NA	NA	NA	NA
WP_005310727.1\|2772454_2774707_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	1.2e-168	43.1
WP_005310725.1\|2774766_2775084_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	5.3e-14	48.1
WP_005300025.1\|2775313_2775532_+	cold shock-like protein CspD	A0A2H4N7Y6	Lake_Baikal_phage	1.2e-17	63.2
WP_005310722.1\|2775642_2776506_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	8.7e-27	30.9
WP_005310720.1\|2777062_2777314_-	hypothetical protein	NA	NA	NA	NA
WP_085941623.1\|2777364_2778100_-\|transposase	IS1-like element ISAs8 family transposase	A0A0U2RK18	Escherichia_phage	5.8e-80	65.2
WP_005310714.1\|2778411_2778699_-	type VI secretion system PAAR protein	G4KK81	Yersinia_phage	4.6e-09	39.4
WP_005310712.1\|2778731_2778917_+	hypothetical protein	NA	NA	NA	NA
WP_005310710.1\|2778990_2780427_-	membrane protein	NA	NA	NA	NA
WP_005310708.1\|2785350_2785956_-	type VI secretion system-associated protein TagO	NA	NA	NA	NA
WP_005310706.1\|2785955_2787494_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_155268744.1\|2787496_2787637_-	hypothetical protein	NA	NA	NA	NA
WP_088814108.1\|2787759_2788677_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_085941624.1\|2791231_2791942_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_042468905.1\|2792034_2793369_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_005310697.1\|2793371_2793887_-	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_042468903.1\|2793886_2795053_-	type VI secretion system-associated FHA domain protein TagH	NA	NA	NA	NA
WP_042468909.1\|2795093_2796092_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_042468902.1\|2796055_2797822_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_005310689.1\|2797825_2798257_-\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_076611341.1\|2798430_2799348_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005310683.1\|2800704_2802441_+	C4-dicarboxylic acid transporter DauA	A0A2H4J153	uncultured_Caudovirales_phage	3.4e-30	24.7
WP_076611341.1\|2805695_2806613_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_15

2844080 : 2917623

Salmonella_phage(28.57%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|2844080_2844998_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005310595.1\|2845230_2845731_+	thioredoxin family protein	NA	NA	NA	NA
WP_005310593.1\|2845792_2846416_+	glutathione S-transferase	NA	NA	NA	NA
WP_088814258.1\|2846499_2847171_-	maleylacetoacetate isomerase	NA	NA	NA	NA
WP_088814259.1\|2847211_2848210_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_088814260.1\|2849367_2850480_-	4-hydroxyphenylpyruvate dioxygenase	NA	NA	NA	NA
WP_005310586.1\|2850738_2851371_-	haloacid dehalogenase-like hydrolase	NA	NA	NA	NA
WP_011898835.1\|2851388_2852048_-	TIGR01621 family pseudouridine synthase	NA	NA	NA	NA
WP_076611341.1\|2852657_2853575_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005310581.1\|2854929_2856492_-	methyl-accepting chemotaxis protein	A0A1B0V854	Salmonella_phage	5.6e-32	45.3
WP_011898838.1\|2856984_2857641_+	Bax inhibitor-1/YccA family protein	A0A2H4JFM9	uncultured_Caudovirales_phage	4.0e-48	53.1
WP_042468686.1\|2857805_2859959_+	TIGR01666 family membrane protein	NA	NA	NA	NA
WP_005310577.1\|2859985_2860327_+	TusE/DsrC/DsvC family sulfur relay protein	NA	NA	NA	NA
WP_042468689.1\|2860385_2861156_-	cell division protein DedD	NA	NA	NA	NA
WP_088814262.1\|2861356_2862604_-	bifunctional tetrahydrofolate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_005310570.1\|2862618_2863482_-	acetyl-CoA carboxylase carboxyltransferase subunit beta	NA	NA	NA	NA
WP_042468693.1\|2863601_2864411_-\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_011898842.1\|2864577_2866716_-	pilus assembly protein TapV	NA	NA	NA	NA
WP_005310564.1\|2866994_2868011_-	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_042468695.1\|2868178_2869312_-	4-phosphoerythronate dehydrogenase	NA	NA	NA	NA
WP_042468696.1\|2869680_2870403_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_042468699.1\|2870487_2871318_-	membrane protein	NA	NA	NA	NA
WP_076611341.1\|2872331_2873249_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814343.1\|2874481_2875618_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_005310555.1\|2875962_2876331_+	hypothetical protein	NA	NA	NA	NA
WP_005310553.1\|2876350_2876890_+	hydrolase	NA	NA	NA	NA
WP_011898844.1\|2877322_2879200_+	S8 family serine peptidase	A0A1V0S9L2	Catovirus	5.2e-16	20.8
WP_005310548.1\|2879218_2879680_+	hypothetical protein	NA	NA	NA	NA
WP_088814263.1\|2880135_2882517_+	glycoside hydrolase family 3 protein	NA	NA	NA	NA
WP_017412773.1\|2882619_2883597_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_005310539.1\|2883951_2886324_-	phosphoenolpyruvate synthase	A0A1V0SGR7	Hokovirus	3.7e-176	38.0
WP_088814108.1\|2886938_2887856_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005310536.1\|2888657_2888945_-	hypothetical protein	NA	NA	NA	NA
WP_042469111.1\|2889309_2890686_+	amino acid permease	NA	NA	NA	NA
WP_042469165.1\|2892231_2892699_+	hypothetical protein	NA	NA	NA	NA
WP_157668961.1\|2892930_2893083_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|2893127_2894045_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005310508.1\|2894608_2895058_+	hypothetical protein	NA	NA	NA	NA
WP_088814385.1\|2895161_2898053_+	hypothetical protein	NA	NA	NA	NA
WP_042468588.1\|2898052_2898892_+	hypothetical protein	NA	NA	NA	NA
WP_005310502.1\|2898994_2900419_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_005310500.1\|2900454_2901015_+	hypothetical protein	NA	NA	NA	NA
WP_042468587.1\|2901035_2902349_+	hypothetical protein	NA	NA	NA	NA
WP_005310495.1\|2902445_2904092_+	hypothetical protein	NA	NA	NA	NA
WP_017412350.1\|2904217_2905420_+	Bcr/CflA family multidrug efflux MFS transporter	S4TR35	Salmonella_phage	1.8e-22	25.1
WP_005310491.1\|2907059_2907527_-	DUF4357 domain-containing protein	NA	NA	NA	NA
WP_042468585.1\|2907724_2908405_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.7e-30	35.9
WP_042468584.1\|2908432_2910874_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_085941475.1\|2910828_2911938_+	carotenoid 1,2-hydratase	NA	NA	NA	NA
WP_011898849.1\|2912137_2913091_-	hypothetical protein	NA	NA	NA	NA
WP_042468582.1\|2913610_2914099_+	MgtC/SapB family protein	G3MA03	Bacillus_virus	7.4e-15	39.8
WP_088814112.1\|2915514_2916432_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|2916705_2917623_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_16

2934042 : 2998913

uncultured_Mediterranean_phage(14.29%)

integrase,transposase,protease

attL 2936938:2936997|attR 2951501:2952573

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088814108.1\|2934042_2934960_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_052521856.1\|2936466_2936829_+	hypothetical protein	NA	NA	NA	NA
2936938:2936997	attL	NA	NA	NA	NA
WP_076611341.1\|2937026_2937944_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468938.1\|2938119_2938599_+	redox-sensitive transcriptional activator SoxR	NA	NA	NA	NA
WP_005314674.1\|2938661_2939249_+	methyltransferase	NA	NA	NA	NA
WP_005314677.1\|2939251_2939662_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_042468939.1\|2939755_2941171_-	NAD(P)-binding protein	NA	NA	NA	NA
WP_005314684.1\|2941183_2945641_-	glutamate synthase large subunit	NA	NA	NA	NA
WP_088814343.1\|2946207_2947344_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_139742367.1\|2947464_2948217_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_139403285.1\|2948236_2950000_+	hypothetical protein	NA	NA	NA	NA
WP_157668962.1\|2950132_2950531_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|2950553_2951471_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_087757302.1\|2952513_2952945_-\|protease	protease	NA	NA	NA	NA
2951501:2952573	attR	NA	NA	NA	NA
WP_005314666.1\|2954405_2955050_-	DUF2913 family protein	NA	NA	NA	NA
WP_088814386.1\|2955187_2956414_-	DEAD/DEAH box helicase	A0A1B1IS59	uncultured_Mediterranean_phage	9.1e-46	29.2
WP_017413054.1\|2956757_2957291_-	spermidine N1-acetyltransferase	NA	NA	NA	NA
WP_042467992.1\|2957405_2958071_-	DedA family protein	NA	NA	NA	NA
WP_017413053.1\|2958393_2959356_+	autotransporter domain-containing protein	NA	NA	NA	NA
WP_005314653.1\|2959732_2960587_+	DNA-binding protein	A0A2R2ZH57	Clostridioides_phage	3.2e-21	28.8
WP_042467990.1\|2962381_2963548_-	DUF1615 domain-containing protein	NA	NA	NA	NA
WP_005314639.1\|2963764_2965423_-	2-isopropylmalate synthase	NA	NA	NA	NA
WP_017412104.1\|2965955_2969180_-	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_005314635.1\|2969196_2970348_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	1.4e-48	32.9
WP_005314633.1\|2971024_2971837_-	4-hydroxy-tetrahydrodipicolinate reductase	NA	NA	NA	NA
WP_017412106.1\|2972084_2973053_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_005314627.1\|2973463_2974798_+	Na+/H+ antiporter NhaC family protein	NA	NA	NA	NA
WP_005314624.1\|2974952_2975561_+	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_005314623.1\|2975816_2976470_+	ribose-5-phosphate isomerase RpiA	NA	NA	NA	NA
WP_005314621.1\|2976698_2977931_+	phosphoglycerate dehydrogenase	A0A1V0SBV6	Catovirus	6.9e-110	48.9
WP_005314618.1\|2978115_2978496_-	diacylglycerol kinase	NA	NA	NA	NA
WP_017412107.1\|2978650_2979712_+	3-deoxy-7-phosphoheptulonate synthase	S4VUY9	Pandoravirus	9.2e-87	50.0
WP_034282866.1\|2979828_2980599_-	ATP-binding cassette domain-containing protein	A0A1M7XV31	Cedratvirus	6.0e-11	30.3
WP_005314605.1\|2980697_2981705_-	vitamin B12 ABC transporter permease BtuC	NA	NA	NA	NA
WP_005314604.1\|2981808_2982540_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005314602.1\|2982651_2983008_+	DMT family protein	NA	NA	NA	NA
WP_042467989.1\|2983067_2984207_+	PilT/PilU family type 4a pilus ATPase	NA	NA	NA	NA
WP_088814267.1\|2984480_2985752_+	glucose-1-phosphate adenylyltransferase	NA	NA	NA	NA
WP_088814387.1\|2985885_2986377_+	WbuC family cupin fold metalloprotein	NA	NA	NA	NA
WP_017412111.1\|2986472_2986715_-	LuxR family transcriptional regulator	NA	NA	NA	NA
WP_042467987.1\|2986711_2988982_-	Fe(2+) transporter permease subunit FeoB	NA	NA	NA	NA
WP_005314583.1\|2988978_2989206_-	ferrous iron transport protein A	NA	NA	NA	NA
WP_085941442.1\|2989280_2989655_+	stress response translation initiation inhibitor YciH	NA	NA	NA	NA
WP_005314579.1\|2989899_2990457_+	TMEM165/GDT1 family protein	NA	NA	NA	NA
WP_005314578.1\|2990709_2991648_+	DUF2157 domain-containing protein	NA	NA	NA	NA
WP_005314577.1\|2991684_2992692_+	DUF4401 domain-containing protein	NA	NA	NA	NA
WP_005314576.1\|2992688_2993192_+	GDYXXLXY domain-containing protein	NA	NA	NA	NA
WP_017412979.1\|2993265_2994012_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_034282846.1\|2994127_2994874_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_042467985.1\|2995092_2996106_-	GGDEF domain-containing protein	G3MA91	Bacillus_virus	3.8e-13	29.8
WP_005314572.1\|2996802_2997111_-	hypothetical protein	NA	NA	NA	NA
WP_088814123.1\|2997995_2998913_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_17

3054632 : 3125246

Prochlorococcus_phage(42.86%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017412019.1\|3054632_3055214_-\|tRNA	tRNA adenosine(34) deaminase TadA	NA	NA	NA	NA
WP_005320165.1\|3056717_3058325_+	malate synthase A	NA	NA	NA	NA
WP_005320166.1\|3058400_3059714_+	isocitrate lyase	NA	NA	NA	NA
WP_005320168.1\|3059809_3060511_-	DnaA inactivator Hda	NA	NA	NA	NA
WP_042467283.1\|3060614_3061634_-	DUF2066 domain-containing protein	NA	NA	NA	NA
WP_005320172.1\|3061783_3062410_-	uracil phosphoribosyltransferase	NA	NA	NA	NA
WP_005320174.1\|3062585_3063623_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.9e-76	46.8
WP_085941584.1\|3063643_3064294_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.6e-25	39.4
WP_005320178.1\|3064411_3065173_-	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_011898552.1\|3065526_3066870_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_005320182.1\|3066866_3067901_-	PAS domain-containing protein	NA	NA	NA	NA
WP_085941583.1\|3069684_3070521_-	DUF2726 domain-containing protein	NA	NA	NA	NA
WP_005320186.1\|3070744_3071257_+	glycine cleavage system protein R	NA	NA	NA	NA
WP_005320188.1\|3071331_3073401_+	polyphosphate kinase 1	NA	NA	NA	NA
WP_005320190.1\|3073390_3074881_+	exopolyphosphatase	NA	NA	NA	NA
WP_042467276.1\|3074966_3076226_-	magnesium transporter	NA	NA	NA	NA
WP_088814222.1\|3079824_3080742_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042467275.1\|3081011_3082103_-	flagellar assembly peptidoglycan hydrolase FlgJ	A0A0A7RU71	Clostridium_phage	6.7e-16	35.4
WP_005320200.1\|3083192_3083864_-	flagellar basal body L-ring protein FlgH	NA	NA	NA	NA
WP_005320202.1\|3083924_3084713_-	flagellar basal-body rod protein FlgG	NA	NA	NA	NA
WP_005320205.1\|3084727_3085474_-	flagellar basal-body rod protein FlgF	NA	NA	NA	NA
WP_017412904.1\|3085605_3086946_-	flagellar hook protein FlgE	NA	NA	NA	NA
WP_005320209.1\|3086956_3087685_-	flagellar hook assembly protein FlgD	NA	NA	NA	NA
WP_042467272.1\|3087700_3088120_-	flagellar basal body rod protein FlgC	NA	NA	NA	NA
WP_005320212.1\|3088119_3088518_-	flagellar basal body rod protein FlgB	NA	NA	NA	NA
WP_005320215.1\|3088581_3089406_-	protein-glutamate O-methyltransferase	NA	NA	NA	NA
WP_088814271.1\|3089424_3090336_-	chemotaxis protein CheV	Q56AR1	Bacillus_thuringiensis_phage	7.5e-37	32.8
WP_088814391.1\|3090306_3091164_+	flagellar basal body P-ring formation protein FlgA	NA	NA	NA	NA
WP_005320221.1\|3091254_3091575_+	flagellar biosynthesis anti-sigma factor FlgM	NA	NA	NA	NA
WP_088814392.1\|3091574_3091988_+	flagellar protein FlgN	NA	NA	NA	NA
WP_005320225.1\|3092031_3092574_-	phosphodiesterase	NA	NA	NA	NA
WP_042467270.1\|3092585_3094238_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_042467268.1\|3094477_3095374_+	DMT family transporter	NA	NA	NA	NA
WP_005320231.1\|3095409_3096102_-	16S rRNA pseudouridine(516) synthase RsuA	NA	NA	NA	NA
WP_088814272.1\|3096275_3097463_+	HD-GYP domain-containing protein	NA	NA	NA	NA
WP_088814108.1\|3097632_3098550_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_017412982.1\|3098904_3099798_+	EamA family transporter	NA	NA	NA	NA
WP_076611341.1\|3100941_3101859_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042469080.1\|3102956_3103349_-	DUF2750 domain-containing protein	NA	NA	NA	NA
WP_005320238.1\|3103443_3104001_-	hypothetical protein	NA	NA	NA	NA
WP_005320240.1\|3104251_3104500_+	TIGR02647 family protein	NA	NA	NA	NA
WP_011898543.1\|3104486_3104792_-	hypothetical protein	NA	NA	NA	NA
WP_005331438.1\|3104896_3105106_-	cold-shock protein	A0A1W6JNX5	Morganella_phage	1.1e-15	60.0
WP_076611341.1\|3107150_3108068_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005320258.1\|3108741_3109728_-	alpha-ketoacid dehydrogenase subunit beta	A0A0K0KW14	Prochlorococcus_phage	1.8e-07	28.8
WP_005320262.1\|3109830_3110925_-	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	NA	NA	NA	NA
WP_005320264.1\|3111199_3112225_-	succinylglutamate desuccinylase	NA	NA	NA	NA
WP_017412738.1\|3112504_3112714_-	DUF1127 domain-containing protein	NA	NA	NA	NA
WP_017412739.1\|3113235_3114129_+	DNA replication terminus site-binding protein	NA	NA	NA	NA
WP_011898541.1\|3114302_3118145_-	DEAD/DEAH box helicase	G8DDA1	Micromonas_pusilla_virus	6.4e-45	30.3
WP_005319007.1\|3118369_3119023_-	DUF480 domain-containing protein	NA	NA	NA	NA
WP_042468837.1\|3119177_3120878_-	ligase	NA	NA	NA	NA
WP_088814343.1\|3122191_3123328_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_076611341.1\|3124328_3125246_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_18

3503786 : 3557555

Cronobacter_phage(10.0%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005316946.1\|3503786_3504320_+\|protease	SprT family zinc-dependent metalloprotease	A0A060AI19	Cronobacter_phage	6.8e-06	31.0
WP_005316947.1\|3504393_3505083_+	deoxyribonuclease	NA	NA	NA	NA
WP_005316949.1\|3505213_3505945_+	16S rRNA (uracil(1498)-N(3))-methyltransferase	NA	NA	NA	NA
WP_005316951.1\|3505996_3506950_+	glutathione synthase	NA	NA	NA	NA
WP_076611341.1\|3508717_3509635_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_011899080.1\|3509829_3510861_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_011898468.1\|3510932_3511520_+	YqgE/AlgH family protein	NA	NA	NA	NA
WP_005316956.1\|3511566_3511989_+	Holliday junction resolvase RuvX	NA	NA	NA	NA
WP_005316958.1\|3512131_3513094_-	HTH-type transcriptional regulator YidZ	NA	NA	NA	NA
WP_042468776.1\|3513116_3514268_-	MFS transporter	NA	NA	NA	NA
WP_080697424.1\|3514581_3515730_-	FOX/MOX family class C beta-lactamase	NA	NA	NA	NA
WP_005316965.1\|3515954_3516875_+	MoxR family ATPase	NA	NA	NA	NA
WP_017412666.1\|3516874_3517879_+	DUF58 domain-containing protein	NA	NA	NA	NA
WP_042468773.1\|3517865_3519839_+	DUF3488 domain-containing transglutaminase family protein	NA	NA	NA	NA
WP_005316972.1\|3519941_3521384_-	alanine:cation symporter family protein	NA	NA	NA	NA
WP_005316974.1\|3522126_3523077_+	transaldolase	A0A127KNC6	Cyanophage	4.6e-13	30.7
WP_005316976.1\|3523236_3523419_+	DUF3545 family protein	NA	NA	NA	NA
WP_005316978.1\|3523467_3524016_-	hemerythrin	NA	NA	NA	NA
WP_005316980.1\|3524262_3524931_-	uracil-DNA glycosylase	A0A109ZQN1	Equid_alphaherpesvirus	1.8e-51	48.4
WP_005316983.1\|3524962_3525220_-	hypothetical protein	NA	NA	NA	NA
WP_011899080.1\|3525397_3526429_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_005316999.1\|3526723_3527104_+	autonomous glycyl radical cofactor GrcA	A0A219YAN3	Aeromonas_phage	4.4e-31	60.3
WP_076611341.1\|3527709_3528627_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468530.1\|3529868_3530723_-	3-deoxy-8-phosphooctulonate synthase	E3T537	Cafeteria_roenbergensis_virus	2.3e-48	40.6
WP_042468528.1\|3530974_3531775_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_005317005.1\|3531786_3532170_-	SirB2 family protein	NA	NA	NA	NA
WP_005317007.1\|3532214_3533084_-	peptide chain release factor N(5)-glutamine methyltransferase	NA	NA	NA	NA
WP_005317010.1\|3533133_3534222_-	peptide chain release factor 1	W8EDB3	Pseudomonas_phage	2.2e-06	38.5
WP_042468526.1\|3534275_3535532_-\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_005317016.1\|3535652_3536237_+	outer membrane lipoprotein LolB	NA	NA	NA	NA
WP_017412585.1\|3536263_3537133_+	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
WP_005317019.1\|3537497_3538445_+	ribose-phosphate pyrophosphokinase	A0A2K9L2G2	Tupanvirus	9.2e-46	38.1
WP_042468524.1\|3538546_3540535_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_042468523.1\|3540743_3541385_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_017412588.1\|3541391_3542483_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_005317037.1\|3543909_3545742_-	SLC13 family permease	NA	NA	NA	NA
WP_005317039.1\|3546037_3546760_+	nicotinamide riboside transporter PnuC	A0A2I7SAC7	Vibrio_phage	1.3e-20	29.2
WP_005317041.1\|3546756_3547482_+	nucleoside phosphorylase	NA	NA	NA	NA
WP_005317044.1\|3547629_3548301_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_017412611.1\|3548335_3548662_+	ASCH domain-containing protein	NA	NA	NA	NA
WP_005317048.1\|3548749_3549670_+	alpha/beta hydrolase	L7RDF8	Acanthamoeba_polyphaga_moumouvirus	8.1e-23	31.9
WP_157668966.1\|3549744_3549882_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|3549926_3550844_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042469063.1\|3551567_3554327_+	hypothetical protein	NA	NA	NA	NA
WP_017412609.1\|3554323_3555994_-	molecular chaperone HscC	F2Y0P3	Organic_Lake_phycodnavirus	4.5e-72	32.7
WP_005317065.1\|3556230_3556572_+	DUF1622 domain-containing protein	NA	NA	NA	NA
WP_088814162.1\|3556637_3557555_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_19

3802937 : 3866819

Streptococcus_phage(20.0%)

transposase,holin,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|3802937_3803855_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005317818.1\|3804697_3804913_+	hypothetical protein	NA	NA	NA	NA
WP_005317820.1\|3804950_3805706_-	DNA/RNA non-specific endonuclease	X2KR27	Campylobacter_phage	5.1e-23	29.1
WP_088814298.1\|3805955_3806891_-	cytochrome-c peroxidase	NA	NA	NA	NA
WP_088814343.1\|3806917_3808054_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_042468556.1\|3808666_3809392_+	carbonic anhydrase family protein	NA	NA	NA	NA
WP_005317829.1\|3809466_3810375_-	pseudouridine-5'-phosphate glycosidase	NA	NA	NA	NA
WP_042468555.1\|3810368_3811460_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005317834.1\|3811657_3812167_+	RNA methyltransferase	NA	NA	NA	NA
WP_005317835.1\|3812294_3812663_-	hypothetical protein	NA	NA	NA	NA
WP_005317837.1\|3812747_3813494_-	hypothetical protein	NA	NA	NA	NA
WP_005317842.1\|3813702_3814131_+	universal stress protein	NA	NA	NA	NA
WP_005317845.1\|3814198_3814834_-	murein L,D-transpeptidase catalytic domain family protein	NA	NA	NA	NA
WP_042468553.1\|3814989_3816243_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.7e-93	46.5
WP_011898405.1\|3816340_3817444_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	9.0e-61	41.2
WP_005317854.1\|3817670_3818063_-	sigma factor-binding protein Crl	NA	NA	NA	NA
WP_005317857.1\|3818123_3819392_-	esterase FrsA	NA	NA	NA	NA
WP_005317860.1\|3819502_3819970_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_005317863.1\|3820005_3820311_-	hypothetical protein	NA	NA	NA	NA
WP_005317866.1\|3820901_3822353_+	aminoacyl-histidine dipeptidase	NA	NA	NA	NA
WP_005317868.1\|3822751_3822871_+	hypothetical protein	NA	NA	NA	NA
WP_005317874.1\|3823074_3824082_-	dipeptide ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.9e-17	28.1
WP_042468552.1\|3824078_3825137_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.5e-07	26.8
WP_017412678.1\|3825162_3826980_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_017412677.1\|3827130_3828174_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_088814299.1\|3828850_3829768_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814343.1\|3831162_3832299_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_017411857.1\|3834932_3835688_+	DUF3450 domain-containing protein	NA	NA	NA	NA
WP_005317892.1\|3835684_3837049_+	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_005317894.1\|3837059_3837587_+	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_005317897.1\|3837654_3838062_+	biopolymer transporter ExbD	NA	NA	NA	NA
WP_005317900.1\|3838078_3838714_+	energy transducer TonB	NA	NA	NA	NA
WP_042468813.1\|3838725_3839961_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_088814300.1\|3840256_3843256_-	chitinase	A0A1X9VNM7	Mimivirus	2.6e-25	29.1
WP_034283532.1\|3843786_3845931_+	ExeM/NucH family extracellular endonuclease	NA	NA	NA	NA
WP_042469031.1\|3847015_3848431_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_017411852.1\|3850906_3851560_+	opacity-associated protein OapA	NA	NA	NA	NA
WP_005317918.1\|3851831_3852041_+	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	4.8e-16	58.7
WP_005317921.1\|3853403_3853949_-	oligoribonuclease	Q8B5Y0	Diachasmimorpha_longicaudata_entomopoxvirus	2.7e-26	36.4
WP_017411851.1\|3853995_3855075_+	small ribosomal subunit biogenesis GTPase RsgA	NA	NA	NA	NA
WP_005317927.1\|3855114_3855987_+	phosphatidylserine decarboxylase	NA	NA	NA	NA
WP_005317929.1\|3855983_3856253_+	DUF2132 domain-containing protein	NA	NA	NA	NA
WP_005317932.1\|3856242_3856506_+	DUF2960 domain-containing protein	NA	NA	NA	NA
WP_005317936.1\|3856508_3856907_+	hypothetical protein	NA	NA	NA	NA
WP_005317941.1\|3857139_3857634_-	hypothetical protein	NA	NA	NA	NA
WP_005317944.1\|3857805_3859779_+	EAL domain-containing protein	G3MA91	Bacillus_virus	1.7e-09	25.9
WP_011898395.1\|3859853_3860201_-	ribonuclease E inhibitor RraB	NA	NA	NA	NA
WP_088814301.1\|3860621_3862898_+\|protease	M6 family metalloprotease domain-containing protein	NA	NA	NA	NA
WP_085941570.1\|3863292_3863427_-	hypothetical protein	NA	NA	NA	NA
WP_005317957.1\|3863679_3864897_-	hypothetical protein	NA	NA	NA	NA
WP_042468084.1\|3865139_3866819_-\|holin	choline dehydrogenase	A0A1V0S9M4	Catovirus	8.7e-47	27.6

DBSCAN-SWA_20

3877432 : 3956984

Bacillus_phage(22.22%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017412397.1\|3877432_3878146_-\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_042468080.1\|3878451_3879519_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_042468079.1\|3879735_3880917_+	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_042468078.1\|3881003_3882533_-	cyclic diguanylate phosphodiesterase	NA	NA	NA	NA
WP_005317998.1\|3882857_3883763_+	TIGR01777 family protein	NA	NA	NA	NA
WP_017412392.1\|3883846_3886294_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_005318003.1\|3886348_3887047_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.5e-32	38.4
WP_005318006.1\|3887045_3887645_+	arylesterase	NA	NA	NA	NA
WP_042468076.1\|3887734_3888679_-	chemotaxis protein CheV	Q56AR1	Bacillus_thuringiensis_phage	3.4e-32	30.2
WP_088814302.1\|3889005_3899265_-	retention module-containing protein	NA	NA	NA	NA
WP_088814303.1\|3899491_3901153_-	putative transporter	NA	NA	NA	NA
WP_017412882.1\|3901270_3901906_-	hemolysin III family protein	NA	NA	NA	NA
WP_034283547.1\|3902130_3903666_+	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_005318063.1\|3903751_3904303_+	septation protein A	NA	NA	NA	NA
WP_005318066.1\|3904329_3904626_+	YciI family protein	NA	NA	NA	NA
WP_005318069.1\|3904707_3905478_-	3'(2'),5'-bisphosphate nucleotidase CysQ	NA	NA	NA	NA
WP_005318073.1\|3905645_3905966_+	ComEA family DNA-binding protein	NA	NA	NA	NA
WP_005318075.1\|3906060_3906972_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	1.8e-62	47.3
WP_017412884.1\|3907185_3908583_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	7.6e-81	38.8
WP_011898383.1\|3908658_3909630_-	response regulator	NA	NA	NA	NA
WP_005318084.1\|3909983_3910682_+	hypothetical protein	NA	NA	NA	NA
WP_005318087.1\|3910753_3911608_+	AAA family ATPase	A0A1B1P8D0	Bacillus_phage	2.4e-08	28.4
WP_042468519.1\|3911743_3912379_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_042468520.1\|3912440_3913604_-	ABC transporter permease	NA	NA	NA	NA
WP_017412891.1\|3913597_3914743_-	ABC transporter permease	NA	NA	NA	NA
WP_005318099.1\|3914742_3915747_-	biotin/lipoyl-binding protein	NA	NA	NA	NA
WP_005318102.1\|3915743_3917102_-	TolC family protein	NA	NA	NA	NA
WP_005318109.1\|3917440_3918406_+\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_005309538.1\|3918431_3918728_+	DNA-binding transcriptional regulator Fis	NA	NA	NA	NA
WP_005318113.1\|3918803_3919436_-	LysE family translocator	NA	NA	NA	NA
WP_017412815.1\|3926554_3926833_-	Pathogenicity locus	NA	NA	NA	NA
WP_088814398.1\|3926905_3927526_-	ribonuclease	NA	NA	NA	NA
WP_005320532.1\|3927792_3928353_+	carbonate dehydratase	NA	NA	NA	NA
WP_011899092.1\|3928457_3928790_+	hypothetical protein	NA	NA	NA	NA
WP_017412813.1\|3928791_3929232_+	hypothetical protein	NA	NA	NA	NA
WP_005320527.1\|3929285_3930194_-	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_005320525.1\|3930374_3930833_+	hypothetical protein	NA	NA	NA	NA
WP_042468897.1\|3930852_3932085_-	MFS transporter	NA	NA	NA	NA
WP_005320516.1\|3932309_3933179_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_042468898.1\|3933375_3934638_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	2.2e-47	32.7
WP_042468899.1\|3934726_3935998_-	membrane protein	NA	NA	NA	NA
WP_076611341.1\|3936471_3937389_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|3937571_3938489_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_034283822.1\|3939047_3940439_+	T3SS effector protein-tyrosine-phosphatase AopH	NA	NA	NA	NA
WP_076611341.1\|3940980_3941898_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_157668969.1\|3942076_3943846_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|3944208_3945126_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814306.1\|3948715_3951721_-	DEAD/DEAH box helicase	A0A2K5B2C2	Erysipelothrix_phage	7.2e-169	37.5
WP_157668970.1\|3951730_3952372_-	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|3952354_3953272_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814308.1\|3953275_3954796_-	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	1.2e-84	41.8
WP_088814309.1\|3954935_3955187_-	hypothetical protein	NA	NA	NA	NA
WP_088814310.1\|3955170_3955809_-	resolvase	A0A1V0E035	Clostridioides_phage	2.8e-06	27.5
WP_076611341.1\|3956066_3956984_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_21

4043999 : 4067428

Cafeteria_roenbergensis_virus(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|4043999_4044917_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_005315988.1\|4045231_4046611_+	ATP-dependent RNA helicase DbpA	E3T5E1	Cafeteria_roenbergensis_virus	1.7e-48	33.1
WP_005315990.1\|4046725_4047016_+	YkgJ family cysteine cluster protein	NA	NA	NA	NA
WP_005315995.1\|4047325_4047724_-	hypothetical protein	NA	NA	NA	NA
WP_005315998.1\|4047996_4049424_+	PepSY domain-containing protein	NA	NA	NA	NA
WP_042468800.1\|4049507_4049726_-	hypothetical protein	NA	NA	NA	NA
WP_085941516.1\|4049836_4050760_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_017412591.1\|4050950_4052306_+	isochorismate synthase	NA	NA	NA	NA
WP_042468798.1\|4052342_4054061_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_005316004.1\|4054050_4054809_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_042468795.1\|4054971_4055832_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_005316010.1\|4055831_4056749_+	o-succinylbenzoate synthase	NA	NA	NA	NA
WP_042468793.1\|4056759_4058166_+	AMP-binding protein	A0A1V0SBX8	Catovirus	5.1e-08	29.5
WP_088814343.1\|4059328_4060465_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_076611341.1\|4061395_4062313_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|4062711_4063629_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|4064872_4065790_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_076611341.1\|4066510_4067428_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_22

4109614 : 4206235

Pseudomonas_phage(11.11%)

integrase,transposase,tRNA

attL 4164597:4164656|attR 4169153:4170216

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076611341.1\|4109614_4110532_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_042468218.1\|4112243_4113053_+	sugar-phosphatase	NA	NA	NA	NA
WP_011899115.1\|4113419_4114199_+	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	A0A2P9FI75	Pseudomonas_phage	6.5e-05	37.0
WP_005316143.1\|4114210_4114627_-	hypothetical protein	NA	NA	NA	NA
WP_005316146.1\|4114739_4116266_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_017412135.1\|4116307_4116706_+	hypothetical protein	NA	NA	NA	NA
WP_005316151.1\|4116735_4117446_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_005316155.1\|4117562_4118531_-	tyrosine recombinase XerC	A0A2P1CCU8	Gordonia_phage	9.5e-14	31.6
WP_085941656.1\|4118523_4119174_-	DUF484 family protein	NA	NA	NA	NA
WP_011899114.1\|4119286_4120117_-	diaminopimelate epimerase	NA	NA	NA	NA
WP_005316164.1\|4120299_4121550_-	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_073531790.1\|4121570_4121747_-	hypothetical protein	NA	NA	NA	NA
WP_005316166.1\|4121820_4122135_+	iron donor protein CyaY	NA	NA	NA	NA
WP_088814323.1\|4122131_4122785_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_017412139.1\|4122904_4125436_-	class I adenylate cyclase	NA	NA	NA	NA
WP_005316194.1\|4125759_4126689_+	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_042468216.1\|4126685_4127420_+	uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_005316199.1\|4127416_4128466_+	heme biosynthesis operon protein HemX	NA	NA	NA	NA
WP_005316202.1\|4128476_4129640_+	hypothetical protein	NA	NA	NA	NA
WP_005316205.1\|4129734_4129986_-	proteinase inhibitor	NA	NA	NA	NA
WP_005316208.1\|4130138_4131149_-	class II fructose-bisphosphatase	NA	NA	NA	NA
WP_042468215.1\|4131366_4132428_+	porin	NA	NA	NA	NA
WP_042468214.1\|4132550_4133438_+	hypothetical protein	NA	NA	NA	NA
WP_042468213.1\|4133670_4135713_+	TonB-dependent siderophore receptor	NA	NA	NA	NA
WP_042468212.1\|4135779_4136400_+	peptidase	NA	NA	NA	NA
WP_042468211.1\|4136577_4137585_+	acyltransferase family protein	NA	NA	NA	NA
WP_005316227.1\|4137735_4138308_+	hypothetical protein	M4QRU0	Micromonas_pusilla_virus	8.9e-20	35.2
WP_005316230.1\|4138433_4139147_+	N-acetyltransferase	NA	NA	NA	NA
WP_011899159.1\|4139342_4139648_+	monooxygenase	NA	NA	NA	NA
WP_034283042.1\|4139675_4140296_-	porin family protein	NA	NA	NA	NA
WP_085941524.1\|4140475_4141183_+	exopolysaccharide biosynthesis protein	NA	NA	NA	NA
WP_011899161.1\|4141252_4142527_-	septum site-determining protein	NA	NA	NA	NA
WP_088814343.1\|4142649_4143786_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_005316246.1\|4144470_4144788_+	hypothetical protein	NA	NA	NA	NA
WP_088814112.1\|4145174_4146092_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_080697428.1\|4146116_4146317_+	hypothetical protein	NA	NA	NA	NA
WP_088814324.1\|4147220_4148351_-	2-iminoacetate synthase ThiH	NA	NA	NA	NA
WP_005316273.1\|4148440_4149208_-	thiazole synthase	NA	NA	NA	NA
WP_005316276.1\|4149209_4149422_-	sulfur carrier protein ThiS	NA	NA	NA	NA
WP_042468928.1\|4149418_4150192_-	HesA/MoeB/ThiF family protein	NA	NA	NA	NA
WP_005316282.1\|4150181_4151756_-	thiamine phosphate synthase	NA	NA	NA	NA
WP_042468927.1\|4151752_4153759_-	phosphomethylpyrimidine synthase ThiC	NA	NA	NA	NA
WP_088814325.1\|4154802_4155720_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_157668971.1\|4155860_4156196_-	hypothetical protein	NA	NA	NA	NA
WP_085941409.1\|4156247_4157409_+\|transposase	IS3-like element ISAs6 family transposase	Q716C2	Shigella_phage	2.8e-84	51.6
WP_076611341.1\|4158350_4159268_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_157668969.1\|4159630_4161400_-	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|4161578_4162496_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_034283822.1\|4162751_4164143_+	T3SS effector protein-tyrosine-phosphatase AopH	NA	NA	NA	NA
4164597:4164656	attL	NA	NA	NA	NA
WP_076611341.1\|4164684_4165602_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_139403308.1\|4166018_4166408_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_017413139.1\|4166320_4166707_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_005320985.1\|4166775_4167006_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_005320982.1\|4167002_4167416_+	PIN domain-containing protein	NA	NA	NA	NA
WP_017413138.1\|4167493_4167847_+	hypothetical protein	NA	NA	NA	NA
WP_076611341.1\|4168206_4169124_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_088814123.1\|4169358_4170276_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
4169153:4170216	attR	NA	NA	NA	NA
WP_011898961.1\|4171285_4172500_-\|transposase	IS256-like element ISAs3 family transposase	A0A218MNI5	uncultured_virus	4.3e-48	47.9
WP_042467981.1\|4173782_4175486_-	amidase	NA	NA	NA	NA
WP_005320510.1\|4175614_4176712_-	agmatine deiminase	M1I1E2	Acanthocystis_turfacea_Chlorella_virus	1.4e-98	51.0
WP_042467979.1\|4176929_4177841_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_005320501.1\|4178065_4178743_-	SDR family oxidoreductase	A0A0K0KVL6	Prochlorococcus_phage	6.4e-09	25.9
WP_034283590.1\|4178764_4179394_-	TIGR04219 family outer membrane beta-barrel protein	NA	NA	NA	NA
WP_005320497.1\|4179486_4179927_-	copper chaperone PCu(A)C	NA	NA	NA	NA
WP_085941508.1\|4179986_4180766_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_005320494.1\|4180769_4181198_-	DUF2753 family protein	NA	NA	NA	NA
WP_005320492.1\|4181503_4182166_+	CatB-related O-acetyltransferase	NA	NA	NA	NA
WP_005320489.1\|4182213_4182921_-	chromosome partitioning protein ParB	NA	NA	NA	NA
WP_011899098.1\|4183088_4184693_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_011899099.1\|4184802_4185102_+	hypothetical protein	NA	NA	NA	NA
WP_005320482.1\|4185170_4185590_-	DUF4426 domain-containing protein	NA	NA	NA	NA
WP_005320479.1\|4185608_4185908_-	YggU family protein	NA	NA	NA	NA
WP_005320477.1\|4185907_4186459_-	YggT family protein	NA	NA	NA	NA
WP_017412059.1\|4186487_4187312_-	pyrroline-5-carboxylate reductase	NA	NA	NA	NA
WP_005320467.1\|4187402_4188104_-	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_005320466.1\|4188143_4189178_+	type IV pilus twitching motility protein PilT	NA	NA	NA	NA
WP_005320465.1\|4189213_4190323_+	PilT/PilU family type 4a pilus ATPase	NA	NA	NA	NA
WP_005320464.1\|4190354_4191128_+	peroxide stress protein YaaA	NA	NA	NA	NA
WP_005320462.1\|4191316_4192540_-	ATP-dependent RNA helicase SrmB	A0A1B1IS59	uncultured_Mediterranean_phage	1.1e-46	30.4
WP_017412061.1\|4192668_4193379_+	methyltransferase	NA	NA	NA	NA
WP_011899101.1\|4193570_4194878_+	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
WP_085941509.1\|4194953_4195217_-	hypothetical protein	NA	NA	NA	NA
WP_005320452.1\|4195188_4195650_-	chemotaxis protein CheX	NA	NA	NA	NA
WP_005320451.1\|4195639_4196098_-	zinc uptake transcriptional repressor Zur	NA	NA	NA	NA
WP_005320450.1\|4196236_4197223_+\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_005320449.1\|4197225_4197375_+	hypothetical protein	NA	NA	NA	NA
WP_005320448.1\|4197460_4197886_-	hypothetical protein	NA	NA	NA	NA
WP_005305063.1\|4197987_4198260_-	DNA-binding protein HU-alpha	A0A249Y2G7	Serratia_phage	3.6e-11	44.2
WP_155601695.1\|4198318_4198486_-	hypothetical protein	NA	NA	NA	NA
WP_005320446.1\|4198579_4199062_+	Rsd/AlgQ family anti-sigma factor	NA	NA	NA	NA
WP_005320440.1\|4199164_4199545_+	PilZ domain-containing protein	NA	NA	NA	NA
WP_042467978.1\|4199637_4201002_-	DNA repair protein RadA	NA	NA	NA	NA
WP_005320435.1\|4201102_4203481_+	PilZ domain-containing protein	NA	NA	NA	NA
WP_088814328.1\|4203527_4204433_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_042467977.1\|4204487_4205498_-	phosphoserine phosphatase SerB	NA	NA	NA	NA
WP_005320429.1\|4205617_4206235_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_23

4573587 : 4623647

Pandoravirus(25.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042467754.1\|4573587_4574424_-\|tRNA	tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA	S4VW33	Pandoravirus	2.1e-17	34.4
WP_085941541.1\|4580446_4581040_-	menaquinone-dependent protoporphyrinogen IX dehydrogenase	NA	NA	NA	NA
WP_021140667.1\|4580978_4582436_-	potassium uptake protein TrkH	NA	NA	NA	NA
WP_017413084.1\|4582472_4583090_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	1.2e-25	38.2
WP_005320555.1\|4584615_4586553_+	acetoacetate--CoA ligase	NA	NA	NA	NA
WP_042468571.1\|4586757_4588905_+	fatty acid oxidation complex subunit alpha FadB	NA	NA	NA	NA
WP_005320563.1\|4588926_4590090_+	acetyl-CoA C-acyltransferase FadA	NA	NA	NA	NA
WP_085941542.1\|4590364_4591099_+	response regulator transcription factor	NA	NA	NA	NA
WP_005320573.1\|4591150_4592596_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_005320576.1\|4592731_4593970_+	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005320579.1\|4594044_4594236_-	hypothetical protein	NA	NA	NA	NA
WP_085941543.1\|4594439_4594688_+	sulfurtransferase TusA	A0A140XB86	Dickeya_phage	2.9e-07	72.2
WP_005320589.1\|4594707_4595055_+	RidA family protein	NA	NA	NA	NA
WP_042468577.1\|4595176_4595833_-	OmpA family lipoprotein	NA	NA	NA	NA
WP_005320598.1\|4596683_4597607_+\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_005320601.1\|4597616_4599686_+\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_017413184.1\|4599817_4600291_-	DUF2846 domain-containing protein	NA	NA	NA	NA
WP_076611341.1\|4601086_4602004_-\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_096071852.1\|4602022_4602694_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_005320633.1\|4602782_4604312_-	nitric oxide reductase transcriptional regulator NorR	NA	NA	NA	NA
WP_005320623.1\|4606045_4607212_+	NADH:flavorubredoxin reductase NorW	NA	NA	NA	NA
WP_042468882.1\|4607263_4607605_+	DUF1971 domain-containing protein	NA	NA	NA	NA
WP_088814339.1\|4607722_4608940_+	4Fe-4S binding protein	NA	NA	NA	NA
WP_042468880.1\|4609230_4610457_+	aromatic amino acid permease	NA	NA	NA	NA
WP_005320617.1\|4610608_4610965_-	molecular chaperone	NA	NA	NA	NA
WP_042468879.1\|4612691_4613468_-	EAL domain-containing protein	NA	NA	NA	NA
WP_088814129.1\|4613782_4614700_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_034283822.1\|4615533_4616925_-	T3SS effector protein-tyrosine-phosphatase AopH	NA	NA	NA	NA
WP_005321603.1\|4617121_4617547_+	chaperonin	NA	NA	NA	NA
WP_088814405.1\|4617746_4619009_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_011898961.1\|4619074_4620289_+\|transposase	IS256-like element ISAs3 family transposase	A0A218MNI5	uncultured_virus	4.3e-48	47.9
WP_157668973.1\|4620326_4620485_+	hypothetical protein	NA	NA	NA	NA
WP_088814108.1\|4620663_4621581_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA
WP_157668974.1\|4621603_4621984_-	hypothetical protein	NA	NA	NA	NA
WP_088814136.1\|4622729_4623647_+\|transposase	IS5-like element ISAs4 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022182

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP022183

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP022186

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection