CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NZ_CP018308	Vibrio mediterranei strain QT6D1 chromosome 1, complete sequence	0 crisprs	cas3,DinG,csx1,DEDDh,csa3	3
NZ_CP018309	Vibrio mediterranei strain QT6D1 chromosome 2	1 crisprs	DEDDh,csa3,cas5f,cas7f,cas6f	2
NZ_CP018310	Vibrio mediterranei strain QT6D1 plasmid unnamed, complete sequence	0 crisprs	NA	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

63536 : 71984

Escherichia_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038223104.1\|63536_64133_-	GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	6.6e-34	45.2
WP_088875852.1\|64360_64534_-	hypothetical protein	NA	NA	NA	NA
WP_062457237.1\|64763_65240_+	WbuC family cupin fold metalloprotein	NA	NA	NA	NA
WP_006074872.1\|65348_66731_+	ATP-dependent RNA helicase DbpA	A0A1B1IS59	uncultured_Mediterranean_phage	7.9e-54	31.8
WP_088875853.1\|66788_67367_-	ferredoxin-type protein NapF	NA	NA	NA	NA
WP_088875854.1\|67382_67991_-	molecular chaperone TorD family protein	A0A077SLS7	Escherichia_phage	4.6e-22	31.9
WP_088875855.1\|68067_68910_-	dimethyl sulfoxide reductase anchor subunit	A0A077SK59	Escherichia_phage	3.7e-22	32.6
WP_063603757.1\|68911_69526_-	dimethylsulfoxide reductase subunit B	A0A077SL61	Escherichia_phage	1.8e-74	58.5
WP_088875856.1\|69536_71984_-	dimethyl sulfoxide reductase subunit A	A0A077SK27	Escherichia_phage	8.6e-221	49.0

DBSCAN-SWA_2

686099 : 693073

Megavirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088876170.1\|686099_686525_-	nucleoside-diphosphate kinase	L7Y4C4	Megavirus	3.2e-22	42.1
WP_088876171.1\|686557_687856_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	1.7e-34	33.1
WP_006072574.1\|688032_688233_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_006072576.1\|688247_688586_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_006072578.1\|688605_690456_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	2.7e-110	40.2
WP_006072580.1\|690479_690995_-	co-chaperone HscB	NA	NA	NA	NA
WP_006072581.1\|691062_691386_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	2.3e-25	51.4
WP_006072582.1\|691444_691825_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	4.1e-53	77.8
WP_006072583.1\|691858_693073_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	4.8e-31	31.1

DBSCAN-SWA_3

1134549 : 1141248

Escherichia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088876363.1\|1134549_1135650_-	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES42	Bathycoccus_sp._RCC1105_virus	1.7e-43	32.1
WP_088876364.1\|1135642_1136584_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_088876365.1\|1136580_1137426_-	hypothetical protein	M4QRX9	Synechococcus_phage	1.0e-08	31.3
WP_088876366.1\|1137407_1137812_-	WxcM-like domain-containing protein	NA	NA	NA	NA
WP_088876367.1\|1137827_1138373_-	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A291LA62	Escherichia_phage	3.9e-49	54.2
WP_173670856.1\|1138385_1139258_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.6e-36	37.3
WP_088876369.1\|1139254_1140151_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.6e-108	66.0
WP_088876370.1\|1140150_1141248_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	7.3e-95	51.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP018309

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018309_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018309_1

1351813-1351895

Unclear

Consensus_repeat	Method
ACAGTGAACTGCCGAGTAGGTAG	CRISPRCasFinder

1 spacers

cas6f,cas7f,cas5f

The CRISPR arrays of NZ_CP018309_1

>merge|NZ_CP018309|1|1351813-1351895|CRISPRCasFinder
ACAGTGAACTGCCGAGTAGGTAGCTGATAATAGCTCGAATGACAGGGGTCTAGGGTCAGACAGGTGAACTGCCGAGTAGGTAG

>NZ_CP018309|1|1|1351813-1351895|CRISPRCasFinder
ACAGTGAACTGCCGAGTAGGTAG	CTGATAATAGCTCGAATGACAGGGGTCTAGGGTCAGA
CAGGTGAACTGCCGAGTAGGTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018309.1\|WP_088878535.1\|1354398_1355391_-\|TniB-family-NTP-binding-protein	unknown	unknown	gnl\|CDD\|377533
NZ_CP018309.1\|WP_006073638.1\|1361292_1361535_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018309.1\|WP_006073644.1\|1358047_1359094_-\|GMP-reductase	unknown	unknown	gnl\|CDD\|235343
NZ_CP018309.1\|WP_088878521.1\|1335623_1336397_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP018309.1\|WP_088878534.1\|1352897_1354292_+\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|223989
NZ_CP018309.1\|WP_088878531.1\|1351084_1351684_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09674_cas6f_CAS-I-F	gnl\|CDD\|187805
NZ_CP018309.1\|WP_088878530.1\|1350023_1351082_+\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	cd09677_cas7f_CAS-I-F	gnl\|CDD\|274205
NZ_CP018309.1\|WP_088878537.1\|1357212_1357902_-\|TnsA-endonuclease-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|378037
NZ_CP018309.1\|WP_088878524.1\|1344406_1344907_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|214866
NZ_CP018309.1\|WP_088878532.1\|1352057_1352264_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP018309.1\|WP_088878529.1\|1348129_1350052_+\|hypothetical-protein	cas5f	cd09736_cas5f_CAS-I-F	gnl\|CDD\|187867
NZ_CP018309.1\|WP_088878538.1\|1359620_1361153_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|182554
NZ_CP018309.1\|WP_161493993.1\|1338055_1340995_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270228
NZ_CP018309.1\|WP_088878528.1\|1346944_1348129_+\|TniQ-family-protein	unknown	unknown	gnl\|CDD\|377670
NZ_CP018309.1\|WP_088878523.1\|1341039_1343784_-\|YadA-like-family-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP018309.1\|WP_161493994.1\|1345549_1345792_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP018309.1\|WP_088878533.1\|1352355_1352904_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018309.1\|WP_088878527.1\|1346076_1346433_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018309.1\|WP_088878536.1\|1355402_1357220_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP018309.1\|WP_006073636.1\|1361571_1362468_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369048

Protein	Function_ID	Function_description	E-value
NZ_CP018309.1\|WP_088878535.1\|1354398_1355391_-\|TniB-family-NTP-binding-protein	gnl\|CDD\|377533	pfam05621, TniB, Bacterial TniB protein. This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein which is involved in Tn5053 mercury resistance transposition.	6.45114e-18
NZ_CP018309.1\|WP_006073644.1\|1358047_1359094_-\|GMP-reductase	gnl\|CDD\|235343	PRK05096, PRK05096, guanosine 5'-monophosphate oxidoreductase; Provisional.	0
NZ_CP018309.1\|WP_088878521.1\|1335623_1336397_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.09032e-38
NZ_CP018309.1\|WP_088878534.1\|1352897_1354292_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	8.74713e-31
NZ_CP018309.1\|WP_088878531.1\|1351084_1351684_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|187805	cd09674, Cas6_I-F, CRISPR/Cas system-associated RAMP superfamily protein Cas6f. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6f is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-F subtype; Possesses RRM fold; also known as Csy4 family.	1.57245e-37
NZ_CP018309.1\|WP_088878530.1\|1350023_1351082_+\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|274205	TIGR02566, conserved_hypothetical_protein, CRISPR type I-F/YPEST-associated protein Csy3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. This family is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	4.13473e-105
NZ_CP018309.1\|WP_088878537.1\|1357212_1357902_-\|TnsA-endonuclease-N-terminal-domain-containing-protein	gnl\|CDD\|378037	pfam08722, Tn7_Tnp_TnsA_N, TnsA endonuclease N terminal. The Tn7 transposase is composed of proteins TnsA and TnsB. DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	7.55753e-14
NZ_CP018309.1\|WP_088878524.1\|1344406_1344907_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|214866	smart00862, Trans_reg_C, Transcriptional regulatory protein, C terminal. This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.	1.73414e-09
NZ_CP018309.1\|WP_088878532.1\|1352057_1352264_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.26795e-13
NZ_CP018309.1\|WP_088878529.1\|1348129_1350052_+\|hypothetical-protein	gnl\|CDD\|187867	cd09736, Csy2_I-F, CRISPR/Cas system-associated RAMP superfamily protein Csy2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog.	6.53923e-69
NZ_CP018309.1\|WP_088878538.1\|1359620_1361153_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|182554	PRK10565, PRK10565, putative carbohydrate kinase; Provisional.	2.03413e-163
NZ_CP018309.1\|WP_161493993.1\|1338055_1340995_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270228	cd01007, PBP2_BvgS_HisK_like, The type 2 periplasmic ligand-binding protein domain of the sensor-kinase BvgS and histidine kinase receptors, and related proteins. This family comprises the periplasmic sensor domain of the two-component sensor-kinase systems, such as the sensor protein BvgS of Bordetella pertussis and histidine kinase receptors (HisK), and uncharacterized related proteins. Typically, the two-component system consists of a membrane spanning sensor-kinase and a cytoplasmic response regulator. It serves as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. The N-terminal sensing domain of the sensor kinase detects extracellular signals, such as small molecule ligands and ions, which then modulate the catalytic activity of the cytoplasmic kinase domain through a phosphorylation cascade. The periplasmic sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.06612e-52
NZ_CP018309.1\|WP_088878528.1\|1346944_1348129_+\|TniQ-family-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	6.37153e-14
NZ_CP018309.1\|WP_088878523.1\|1341039_1343784_-\|YadA-like-family-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	2.47162e-15
NZ_CP018309.1\|WP_161493994.1\|1345549_1345792_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.45553e-09
NZ_CP018309.1\|WP_006073636.1\|1361571_1362468_-\|hypothetical-protein	gnl\|CDD\|369048	pfam06711, DUF1198, Protein of unknown function (DUF1198). This family consists of several bacterial proteins of around 150 residues in length which are specific to Escherichia coli, Salmonella species and Yersinia pestis. The function of this family is unknown.	0.000411525
NZ_CP018309.1\|WP_088878536.1\|1355402_1357220_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.31128e-11

>NZ_CP018309.1|WP_088878531.1|1351084_1351684_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MKWYYRTITFLPERCNNESLAAKCLRVLHGFNYRYETRNTGVSFPLWCDETVGKKVSFISTNKMELDLLFKQHYFVQMEKLQYFSISKTVLVPEGCRYVSFKRCQSIDKVTTAGHERKIRRLEKRAKSRGEPFDPTSFTQKEHTVLSHYHSLEESSSKTNNNFRLNVRMFSEQHNEGGSVFSSYGLSNSEHSLQPVPLI
>NZ_CP018309.1|WP_088878530.1|1350023_1351082_+|type-I-F-CRISPR-associated-protein-Csy3
MKIPSSLAYERSIDPSDVCFFVVWPDDKKTPLTYTSRIQVGQIESASLAYDTSGQPKKSATAEALAHGNPHQVDFCHVPYGASHIECCFSVSFSSELRKPYKCDSSSVKQTLVKLVELYEKKIGWTELATRYLINICDGTWLWKNTRKAYCWNIELTPWPWNREKVEFEDIRNNYMSRKDFEGHKDWLAITEMIETAFSRPNGLAIFEVRATVHLPTNAMVRPSQAFTEKESGSKSKSKSQNSRVFQHTTVDGKRSPILGAFKTGAAIATIDDWYPEATEPLRVGRFGVHREDVTCYRHPSTGKDLFSLLQKADHYIEVLRSNEDPDQETINDIHFVMANLIKGGLFQHKGD
>NZ_CP018309.1|WP_088878529.1|1348129_1350052_+|hypothetical-protein
MQTLKELIESNPDDLKAALKRAFRPLTAHIAIDGKELDALTILVNLTDKTDDQKDLLDRAKCKQKLRDEKWWASCLNCVKYRQSHNPKFPDIRSEGIIRMEALGELPSFLLSSSKIPPCHWSYAHDAKYVNKSALLTNEFCWNGVTSCLAELLRDVDHPLWKTLTKLGCYQKTRKAIAKQLASIAHVTISVPLAPNYLTQISLPDSDTSYISLSPVASLSMQSHFYQGLQDEYLHTSTTRYSRSTNMGVTAMTCGGAFRMLKSNTKFSTTPHHRLNSKRNWLTSEHVHSLAQYQRLNKRLVPENARKALRRKYKIEILNMVNAWLAMQDHTQDSTILVQHLNHDLSCLGDTKRFAYDPAMTKLFTDLLKRALSNSINDGTQHTNGSYLVLPNIRVCGATALSSPVTVGGPSLTAFFGFVHAFERKLNSIYTTFRVGSFAICIHQLHVEKRGLTAEFVEKGNGTISAPATHDDWQCDAVFSLILNTNFAQRIDQQTLITALPKRLARGSAKIAIDDFKYLNSFTTIETAIQSLPIKVGRWISLHTQPTNNLGDLLAAIKEDYQLMASCVGYHLLEEPKDKPNSLRGYKHAFAECIVGLIKSITFGSTTDANTILWSLNSHQNYLVLQPRSISNENTLESSL
>NZ_CP018309.1|WP_088878528.1|1346944_1348129_+|TniQ-family-protein
MFLQRPNPHTNESLESFFIRVANSNGYEDVHRFLEATKRYLQDIDHNGYKSFPTDITRINPYSAKNSSSARTASFLKLAQLTFNEPTDLLGLTINRTDLKYSASTSAVIRGSEVFPRSLLRTNSIPCCPLCLQNDGYASYFWHFEGYDHCHVHDVPLISSCNCSAEYDYRTSGVNGICGNCKEPIAKQSRGSISDAISAVANWLAGNEYKDLPDVPQSYRWGLVHWWMHLNDNKFDHRSFTHFFANWPRAFHSMIDDEIEFNLEHAVVSTSELRLKDLLGRLFFSSIRLPERNLQHNIILSELFSHLEKRLWQNKGLIANLKMNALEVTMLLNCSRDQIASMVEQRILKPNRRTKPNSPIEPTDYLFHFGDIFCLWLAEFQTDEFNRSFYVSRW
>NZ_CP018309.1|WP_088878527.1|1346076_1346433_-|hypothetical-protein
MNLKKLEELDVGYIELEPSIERSVRCTWALNMSLQHVLRSNLSDSLVEKINQINESLGVEVHCIDLNDYKHDFITSTTLNKLIEENEYPKFLWFYSTGGPKRLLFCRLVAFQINRKSF
>NZ_CP018309.1|WP_161493994.1|1345549_1345792_-|IS3-family-transposase
MELVGLESSTSRRRNCYENATVESIYQLLKRERIKLKPCTRMEEARMDIFEYIEMFYTIKRLHGSITRCRQYQIKLKNFY
>NZ_CP018309.1|WP_088878524.1|1344406_1344907_+|helix-turn-helix-domain-containing-protein
MNTRNLGNCVVKADNNKYYIEFPDGTTYHIKKAEYNILIALLDSHPSLVTTESLKLHGWGARNYTGDNSLPVAISNLRKLLSILKIEIINEPRKGYKIFIPKETLTYQDNNHIVKISVKNIIKILCIMFSFLLWLEIYELWVSAACVSNEVSQLACELNDEIFIIK
>NZ_CP018309.1|WP_088878523.1|1341039_1343784_-|YadA-like-family-protein
MKNVILLILTSLLIMSSPSVSAGIIPESAFLKLRIKEAQDLAKEADLHAKQADKHAKEADKHLEELKTSASVANTVAQGASAQAVTATKAAMAAEAHVSEAKALAKSADKRAADADDHAEEAKILAKRADTRAVDAAVSATVAEAHVSEAKALARGADTHAADADDHAAEAKALAEGADKHAADADTHAAAAAASATAADTHAAEAKALAKGADKHAADADTHAVEAKGLAKSADKHAADADTHAAAAAASATAADTHAAEAKALAKGADTHAVEAKGLATAADTHAAEAAASATAADTHAVEAKGLAKSADKHAADADTHAVEAKGLAKSADKHAADADTHAAAAAASATAADTHAAEAKALAKGADTHAVEAKGLAKSADKHAADADTHAAAAAASATAADTHAAEAKALAEGADKHAADADTHAAAAAASATAADTHAAEAKALAEGADKHAADADTHAAAAAASATAADTHAAEAKALAKGADTHAVEAKGLATAADTHAAEAAASATAADTHAVEAKGLAKSADKHAADADTHAAAAAASATAADTHAAEAKALAKGADTHAVEAKGLAKSADKHAADADTHAAAAAASATAADTHAAEAKALAEGADKHAADADTHAAAAAASATAADTHAAEAKALAEGADKHAADADTHAAAAAASATAADTHAAEAKALAKGADKHAADADTHAVEAKGLAKSADKHAAAAKASATAADTHAVEAKGLAKSADKHAAEAKALAKGADKHAADADTHAVEAKGLAKSADKHAAAAMASATVADKHAINAQAQSLTNQLAISDNSSEITTNRKNIEQNSKKIADNTKRIDSLENRFIEMGKEIDSLGAMSVATSQLMQPYSVGKTSIVAGVGHYGESNAIAVGVGVRVTEHLAVKASITANDLTSNVATGAGVMYEF
>NZ_CP018309.1|WP_161493993.1|1338055_1340995_+|transporter-substrate-binding-domain-containing-protein
MVSEEVAQKIKSADSQARHLTRSLANIIASKNSIEQWQPILLAALESNPEVYSLYVGTNTDEFYQIINLDLISSSSSNMKLEESDRWVFVYIHRAEDGKQRKTVTFVDESLHVREQYSLPSKFLPSQRPWFQSALSGDIVKTEPYLFQNMTTSGQTYAFLTPSGHAVVGVDILLSTTSDMLSEIFKQHSSEAFVFRQTGEMVASTRSSPAENTSPNLPLLTMTKTEQALIQKANPLRISNQKHWAPMDYNVLGVPRGYSIDILKMITQMTGIQWEFVNGLDWSTFVRQFNNHSLDALHSLQHTQDGYIQGAFSDPIFSLPFGILVPEHLSSIQSITDLNGEKIALVSGWSILPTLSLPNNYSEIEIIEVNSLFMGIELLKSGEVSGLIDSSIVLKNITQQYFIDDVSVVEDIAPFNQGIDWQFHIVLREKYSELLPVINRAISKIINSEQANLQQKWQSDLSMIQHRLVPHPIFYELMASPQKHGHLVNVLMGSKETYIYLQPVSASTPKEFLAIVLPAEILHKQVLNQVYQTAEVTALLVIPMLWLAWFFGTPIIRTVKSLEQKTLQIQSKDYQQLKPVHSRIRELSLLSKSIGQMATQLQANEKQQEILLDSIIELIAGAIDAKSPYTAKHCSRVPILAMMLADAAESSRRPPFENFCFRSEQEKREFRIAAWLHDCGKLTVPEHIVDKGTKLEANYNRLHEIRMRFEVLWRDIELEGVKKQLNGEPEHQVTTWINGRHKQLQREFSFIASLNTGETVVTEEDIAHLKKIGAQTWARHFDDTIGLSPFEKSKKVHTPEIETLLKDAPEHKIERYHSPSHDYGIKMDAPHLLSNLGEIYNLSITRGTLTKEDRYRINEHMVSGIKMLESLPFPNELKSVPRLATTHHETLSGKGYPRKLSAEDLSTKDRILAIADIFEALTSGDRPYKKAFPMNKVLAIMSDMVQKEQIDADLYSLFIEQEIHLRYAHEFLKPEEDDS
>NZ_CP018309.1|WP_088878521.1|1335623_1336397_-|alpha/beta-hydrolase
MPFAQDIHYIDSAPNKEEKDVIVFLHGFFMDARMFQEQIAYFQDKYRVIAIDLRGFGQTKCIHNNFSLEDLASDVLGVTDSLNIKKFVLVGMSMGGYVAQRIALAHPENIIDLILIGTQSGKDNQATVEQYKNVVELWDDFQARANFVSAMLPVIVGDKHDDQRFWRSVWMTYNKDSISFPMNAMLARDDLELSNIKIPTLIIHGKDDHGIPVKAAYQMHQQIKNSVLIIIEEGRHAVNITSPHRVNEEIYNFLAIH
>NZ_CP018309.1|WP_088878532.1|1352057_1352264_-|helix-turn-helix-transcriptional-regulator
MNELAKTFGNNLRLMRKNKSISQDKLALLADIDRSYIGRIERGEVNITLEKAYQLARVLGCDVRDLLP
>NZ_CP018309.1|WP_088878533.1|1352355_1352904_+|hypothetical-protein
MTKKVRVNRDIYAIISLPSMSEFRVTQIRNLITENSLHYSNKDTARLYVARQLESLKKQGVLESQGVRHNKTYKKTGMFAEANFILKDKRVLTKQSNNEGPIDSASVKPMLIDEKKDIESNLTIALAEIDEYKLLMSRSKSLHNLLLPSHADAVNKAAALVAKLNVWTDAIKLVTQQEAKSC
>NZ_CP018309.1|WP_088878534.1|1352897_1354292_+|DEAD/DEAH-box-helicase-family-protein
MLRKWQAECVSLALSKYRSGHAHFLAQATSGAGKTIMAATLTKQMFESKEIDFVLCFSPSKAVADGIKSTFSQLLECSFNGALGETGCSMTYQSLRFVTKRFWDTLSKYKVLCIFDEIHHCGGDNELNSNSWGYQLLSDVQHAATFTLALTGTPWRSDKTPITLASYTDPEGKIVCDYRYSLAQAVQDGVCRKPKIALIDCEEVKVTESEGLRSYNTIDELLNEGDVTYALILKDQQALLHLIGEAISRLISIQAENPNAGGLIVASSIQEANKIASILTNSYAQSSVVVSYRDTSSHEKIKEFKEAHSKNWIVSVGMVSEGTDIPRLQVCCYLTKIKTELYFRQVLGRILRVTKSPNQEAWLYTFAESNMIRCAEEIETDIPDTCLYLNYECPNSHPSRVDESSQTKAFDAQLFPASVAEISFNWSDDLSASEPSKGKNRDSFESSIQLARFNQRVIEAFRGV
>NZ_CP018309.1|WP_088878535.1|1354398_1355391_-|TniB-family-NTP-binding-protein
MNETREARISKAKRAFVSTPSVTKILHYMDRCRDLSDFESEPTCMMVFGASGVGKTTIIKKYLSQNQRDSEIDGDIVPALHIELPYNAKPVDAARELLLEMGDPLALYETDLTRLTKKLTDLIPFVGVKLIIIDEFQHLVEEKSNRVLTQVGNWLKMILNRTKCPIVLFGMPYSKVVLKANSQLHGRFSIQCELRPFNYQGGKGVFRTFLSHLDRALPFEKEIGLANDDLQKKLYAFSQGNMRSLRNLIYHASVEAIDNNHDTISIEDFVFAAELTSGDKLSTWINPFREDVKITEHMLRPPPRDIGWEDYFKSRKPKSNKKGGGGNMFE
>NZ_CP018309.1|WP_088878536.1|1355402_1357220_-|DDE-type-integrase/transposase/recombinase
MPKKSFSSFNRKSAAPRENLEANDTVIAISDADEETYKDISAFPENIASQIIFRLSILRYLATKCEKIIPRTIEPHRVALQRLHEKNIPSAISIYRWWLVFRAADYNPVSLAPRNNDKGNSKAKVPTLVDALMDQAVERVISGRKIRVRSAYKRVRRKLRQHNLKNGTKYKYPTYESLRKRVKKKTPYELLAAKKGERVAKREFRRMGKKILTSYVLERVEIDHTVVDIFAVHEEHRVPLGRPWLTQLVDCYSKAVIGFYLGFEPPSYVSVSLALKNAILRKDDLLSSFESIENDWLCYGIPDLLVTDNGKEFLSKAFDSACENLLITVHQNKVETPDNKPHVERTYGIVNTSLLDDLPGKAFSQYLHREGYDSVSEATLSLEEIKEIYLIWLIDIYHPSSNQRGTNCPNIAWKNGCKDWEPEEFTGTREELDFKFAISDEKTLTKVGVTVYKELTYSSDRLAEYRGKKGNHKVKFKYNPECMAVIWVLDEDLNEYFTVNAIDYEYASRVSLWQHKYNMKYQAELNSAEYDEDKEIDAEIKIEEIADRSIVKTKKVSSRRRGARHQENTARAKSISADKPVPVQSQTYEEEIANVDNEDWDIDYV
>NZ_CP018309.1|WP_088878537.1|1357212_1357902_-|TnsA-endonuclease-N-terminal-domain-containing-protein
MSSLLSPSTSTLIELESAFDTPARNLTKSRGKNIHRYVSVKMGKRFTVESFLECAACYHFDFEPSIVRFCSQPIRFSYNLNGKSHTYVPDFLAQFDTGEYVLYEVKPDEESARAEFEREWEAKVEGALELGVELELIIEEEILDTVIFRNLKLLHRYASRDNLSHLHQTLLNTLKMNGRQTAKSLGSNLGLNGRKIFPLLCDLLSRNLLQTSLETPLSLESEFDLGCYA
>NZ_CP018309.1|WP_006073644.1|1358047_1359094_-|GMP-reductase
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTRDFTFKHSGRQWSGTPVIAANMDSVGSFEMATALAQHGVMTAMHKHYTVEQWAEFVAGATKETLNKVFVSTGTSERDFEKTKEILALSEDLEFICIDIANGYSEHLVEFVQKVRAEFPTKTISAGNVVTGDMCEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGMIIGDGGCACAGDVAKAFGGGADFVMLGGMLAGHEQSGGEIIEQDGKQFMKFYGMSSQSAMDKHSGGVANYRAAEGKTVLLPYRGDVNNTIQDILGGVRSTCTYVGAAKLKELTKRTTFIRVQEQENNVFGKEG
>NZ_CP018309.1|WP_088878538.1|1359620_1361153_-|NAD(P)H-hydrate-dehydratase
MISSNQNITSLPESLFTSQQVREGEKIVAQQLGIEMYTLMQQAGSSVFELIQTYYSETRKLLVCCGKGNNGGDGYIVAKLSLIAGYDVTVWQVGDSSALKGDALRARDEFLAAGGVIDSPENAVADDVDVIIDALLGTGISGEVRPFYSHVFDRLNQSSKPIISIDTPSGLDTDTGVVLGNTIEADRTVTFIGVKQGLVTGRARAFTGQLHFAGLGVDREFAQQNKANVTLTNKHWLNYLPQRAKDSHKGTHGKLLVVGANNGMSGAAYLASAACLRAGGGLCAVLTHEASATPIRTLLPEAMVDACTTQSLTERANWSSAIAIGVGLGRTAWSARVFDQTLKLAISLDLPVVIDADGLYWLNQRQSDTAVLKNHIITPHPGEAAQLLNCRISDIEKDRFQAIRALQKTYGGVVVLKGAGTLIYDGQSMVVCHAGNPGMSSGGMGDLLTGTILALLGQGKNTMQSATLGTLIHSLAADQESKEHGEVGMLASDLLPQIRLVRNHDNYVSS
>NZ_CP018309.1|WP_006073638.1|1361292_1361535_-|hypothetical-protein
MIEQGVFWTEKLLLLAGVLFIITGIVQYGRRSQDWKGVVTMFYKRVPMSVDEYKRYRLGVALIIFAIVLRFALHIFWPQF
>NZ_CP018309.1|WP_006073636.1|1361571_1362468_-|hypothetical-protein
MKKVGWVKSFGLFVSLLIVTGCTTKFLYSNLDWFIVDYIDDYVTLEDGQEEILTERILVLGDWHKSNELPRYLQQLTDIRNKDPKTVDAEYVSLQMEQVRQHTKRLVAQITPDLYALTQQMTDKQVKELLDNLEQKDEKFIKKYQGLQDEDVRLIYQQRIEENLERWFGPLTEQQKTLASRWANEMDVTVFDWQAHRQQMQHFMRQLLNRRSDLGYFQPEFQRLLNDSESFYSEKLKLKIANNRLVAEKYIALALNSVTEKQHQHLIEEIDGWRDIASDLMTSALLDYSSTEKYAFPS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1178548 : 1187613

Vibrio_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088878423.1\|1178548_1179193_+	hypothetical protein	R9TRM8	Vibrio_phage	1.9e-55	49.8
WP_088878424.1\|1179356_1179653_+	hypothetical protein	NA	NA	NA	NA
WP_088878425.1\|1179639_1180161_+	lysozyme	U3PDH1	Vibrio_phage	4.6e-47	48.7
WP_161493989.1\|1180242_1180944_+	phage antirepressor KilAC domain-containing protein	A0A1W6DWH5	Salmonella_phage	7.8e-50	50.9
WP_151899227.1\|1181248_1184566_+	hypothetical protein	B6DZB5	Enterobacteria_phage	3.9e-131	41.0
WP_088878429.1\|1184729_1184885_+	L-threonine 3-dehydrogenase	R9TPW0	Vibrio_phage	1.7e-21	90.2
WP_006072829.1\|1184954_1185212_-	DUF333 domain-containing protein	NA	NA	NA	NA
WP_088878430.1\|1185421_1186906_-	DUF3943 domain-containing protein	NA	NA	NA	NA
WP_062458858.1\|1187094_1187613_+	NUDIX domain-containing protein	A0A2H4J8B3	uncultured_Caudovirales_phage	1.5e-29	45.5

DBSCAN-SWA_2

1269749 : 1335225

Hokovirus(40.0%)

integrase,transposase

attL 1322174:1322195|attR 1343468:1343489

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_088878482.1\|1269749_1270709_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_088878483.1\|1270705_1271701_-	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_038226873.1\|1271865_1272456_-	SPOR domain-containing protein	NA	NA	NA	NA
WP_088878484.1\|1272700_1275385_+	bifunctional acetate--CoA ligase family protein/GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_006074908.1\|1275394_1276282_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_088878485.1\|1276398_1278432_-	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	NA	NA	NA	NA
WP_088879045.1\|1278644_1279010_-	NADH:ubiquinone oxidoreductase	NA	NA	NA	NA
WP_038226883.1\|1279518_1280751_+	OFA family MFS transporter	NA	NA	NA	NA
WP_088879046.1\|1280903_1283258_+	fatty acid cis/trans isomerase	NA	NA	NA	NA
WP_006074903.1\|1283288_1283474_+	hypothetical protein	NA	NA	NA	NA
WP_151899228.1\|1283523_1284069_-	RES domain-containing protein	NA	NA	NA	NA
WP_088878487.1\|1284065_1284419_-	hypothetical protein	NA	NA	NA	NA
WP_088878488.1\|1284481_1287415_-	TMAO reductase system sensor histidine kinase/response regulator TorS	A0A1V0SGX0	Hokovirus	4.1e-52	33.4
WP_088878489.1\|1287507_1288500_+	TMAO reductase system periplasmic protein TorT	NA	NA	NA	NA
WP_006074898.1\|1288645_1289101_+	methylglyoxal synthase	NA	NA	NA	NA
WP_088878490.1\|1289150_1290065_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_173670908.1\|1290238_1293400_-	response regulator	A0A1V0SGX0	Hokovirus	1.6e-49	30.0
WP_088878492.1\|1293500_1294370_-	YdcF family protein	NA	NA	NA	NA
WP_088878493.1\|1294382_1294781_-	OsmC family protein	NA	NA	NA	NA
WP_088878494.1\|1294907_1296044_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_088878495.1\|1296288_1297395_+	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_088879047.1\|1297441_1297816_-	hypothetical protein	NA	NA	NA	NA
WP_006074887.1\|1297953_1299006_-	3-deoxy-7-phosphoheptulonate synthase AroG	S4W5F1	Pandoravirus	1.8e-79	49.1
WP_151899229.1\|1299387_1301004_+	VRR-NUC domain-containing protein	NA	NA	NA	NA
WP_038226906.1\|1301058_1301739_-	MaoC family dehydratase	NA	NA	NA	NA
WP_088878497.1\|1302302_1303025_+	oxygen-insensitive NADPH nitroreductase	NA	NA	NA	NA
WP_088879048.1\|1303089_1304424_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_088878498.1\|1304435_1305128_-	response regulator transcription factor	W8CYM9	Bacillus_phage	9.4e-32	35.9
WP_088879049.1\|1305749_1307186_+	hypothetical protein	NA	NA	NA	NA
WP_088878499.1\|1307225_1308017_-	EAL domain-containing protein	NA	NA	NA	NA
WP_088878500.1\|1309000_1310257_-	deferrochelatase/peroxidase EfeB	NA	NA	NA	NA
WP_088878501.1\|1310253_1311165_-	EfeM/EfeO family lipoprotein	NA	NA	NA	NA
WP_088878502.1\|1311148_1311991_-	FTR1 family protein	NA	NA	NA	NA
WP_088878503.1\|1311990_1312338_-	cupredoxin domain-containing protein	NA	NA	NA	NA
WP_088879050.1\|1312401_1312956_-	iron transporter	NA	NA	NA	NA
WP_088878505.1\|1313569_1315267_+	AAA family ATPase	NA	NA	NA	NA
WP_088878506.1\|1315263_1316640_+	ATP-dependent helicase	NA	NA	NA	NA
WP_161493990.1\|1317371_1317794_-\|transposase	transposase	NA	NA	NA	NA
WP_173670898.1\|1317691_1317934_-	hypothetical protein	NA	NA	NA	NA
WP_161493991.1\|1318282_1321222_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_088878509.1\|1321266_1323078_-	YadA-like family protein	NA	NA	NA	NA
1322174:1322195	attL	NA	NA	NA	NA
WP_088878510.1\|1323123_1323345_-	hypothetical protein	NA	NA	NA	NA
WP_088878511.1\|1323680_1324181_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_161493992.1\|1324823_1325069_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	7.0e-14	67.2
WP_088878514.1\|1325223_1325709_-	hypothetical protein	NA	NA	NA	NA
WP_088878515.1\|1326219_1327404_+	TniQ family protein	NA	NA	NA	NA
WP_088878516.1\|1329050_1330079_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_088879051.1\|1330612_1331185_+	TIR domain-containing protein	NA	NA	NA	NA
WP_088878517.1\|1331184_1331871_+	hypothetical protein	NA	NA	NA	NA
WP_088878518.1\|1332179_1332728_+	hypothetical protein	NA	NA	NA	NA
WP_088878519.1\|1333682_1334885_+\|transposase	IS91 family transposase	NA	NA	NA	NA
WP_088878520.1\|1335144_1335225_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
1343468:1343489	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018308

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP018309

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection