CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022352	Vibrio sp. 2521-89 chromosome 2, complete sequence	0 crisprs	csa3,cas3	0	0	1	0
NZ_CP022353	Vibrio sp. 2521-89 chromosome 1, complete sequence	2 crisprs	DEDDh,DinG,csx1,cas3,csa3,cas6f,cas7f,cas5f,TnsE_C	0	5	4	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

719303 : 747608

Vibrio_phage(47.62%)

terminase,integrase,portal

attL 718868:718884|attR 749919:749935

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
718868:718884	attL	NA	NA	NA	NA
WP_089070294.1\|719303_720527_-\|integrase	site-specific integrase	R9TMP3	Vibrio_phage	5.5e-184	76.2
WP_089070295.1\|720508_720691_-	hypothetical protein	NA	NA	NA	NA
WP_089070296.1\|720696_720960_-	hypothetical protein	NA	NA	NA	NA
WP_000781499.1\|721178_721844_-	helix-turn-helix domain-containing protein	A0A1V0E8B5	Vibrio_phage	3.8e-70	60.1
WP_089070297.1\|721962_722199_+	helix-turn-helix transcriptional regulator	A0A1V0E8C7	Vibrio_phage	2.1e-20	68.7
WP_089070298.1\|722832_723801_+	helix-turn-helix domain-containing protein	R9TPU9	Vibrio_phage	3.9e-92	57.1
WP_089070299.1\|723864_724683_+	hypothetical protein	NA	NA	NA	NA
WP_089070300.1\|724796_725642_+	hypothetical protein	A0A2R2Z334	Escherichia_phage	6.4e-14	25.7
WP_089070301.1\|725634_727332_+\|terminase	terminase	B0FEF1	Escherichia_phage	3.1e-217	65.6
WP_089070302.1\|727328_729416_+\|portal	portal protein	A0A088CE71	Shigella_phage	3.1e-203	58.3
WP_089070303.1\|729774_730638_+	hypothetical protein	NA	NA	NA	NA
WP_001128531.1\|730972_731284_+	membrane protein	R9TR41	Vibrio_phage	2.2e-20	47.4
WP_089070304.1\|731352_731871_+	secretion activator protein	Q6VT55	Vibrio_phage	9.4e-61	63.2
WP_000835322.1\|732302_732524_+	hypothetical protein	NA	NA	NA	NA
WP_000228309.1\|732526_733105_+	hypothetical protein	A0A1V0E8A2	Vibrio_phage	7.9e-24	36.9
WP_089070563.1\|733116_733377_+	hypothetical protein	NA	NA	NA	NA
WP_033933208.1\|733494_734499_+	hypothetical protein	A0A1I9KFD1	Aeromonas_phage	1.2e-22	32.9
WP_000207893.1\|734561_735767_+	DUF4043 family protein	A0A088CC32	Shigella_phage	2.7e-135	58.3
WP_089070305.1\|735781_736162_+	hypothetical protein	M4MCI2	Vibrio_phage	1.0e-08	31.1
WP_089070306.1\|736219_736684_+	hypothetical protein	A0A1I9KFH0	Aeromonas_phage	4.2e-28	58.4
WP_089070307.1\|736686_737286_+	hypothetical protein	NA	NA	NA	NA
WP_069217328.1\|737285_737915_+	hypothetical protein	A0A1I9KFD0	Aeromonas_phage	1.9e-23	33.3
WP_089070308.1\|737929_740434_+	right-handed parallel beta-helix repeat-containing protein	A0A240EWW2	Vibrio_phage	3.0e-19	31.2
WP_089070309.1\|740506_742114_+	hypothetical protein	A0A1I9KFD2	Aeromonas_phage	1.7e-129	45.3
WP_089070310.1\|742113_744090_+	DUF1983 domain-containing protein	A0A2L1IV54	Escherichia_phage	6.6e-54	33.3
WP_000989817.1\|744094_744457_+	hypothetical protein	NA	NA	NA	NA
WP_089070564.1\|744497_744839_+	hypothetical protein	NA	NA	NA	NA
WP_089070311.1\|744838_745489_+	hypothetical protein	A0A1I9KFE8	Aeromonas_phage	5.7e-39	44.7
WP_089070312.1\|745492_745870_+	hypothetical protein	A0A1I9KFD7	Aeromonas_phage	4.2e-18	44.9
WP_000331793.1\|745872_746133_+	hypothetical protein	NA	NA	NA	NA
WP_089070313.1\|746132_747608_+	ATPase	M4MHC7	Vibrio_phage	1.3e-41	35.3
749919:749935	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP022353

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022353_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022353_1

1710128-1710277

TypeI-A

Consensus_repeat	Method
TTTCTTGGCTGCCTATTCGGCAGAACAC	CRISPRCasFinder
TTTCTTGGCTGCCTATTCGGCAGAACACAT	PILER-CR

2 spacers

csa3,cas6f,cas7f,cas5f

The CRISPR arrays of NZ_CP022353_1

>merge|NZ_CP022353|1|1710128-1710277|CRISPRCasFinder,PILER-CR
ATTCTTGGCTGCCTATTCGGCAGAACACATGCAGTCGATGCAGCAGGAATAGAGTGGCGATTTCTTGGCTGCCTATTCGGCAGAACACATTTTATTCGGCAGGTCGATGTTTGGGTCATTTTTCTTGGCTGCCTATTCGGCAGAACACTA

>NZ_CP022353|1|1|1710128-1710275|CRISPRCasFinder
ATTCTTGGCTGCCTATTCGGCAGAACAC	ATGCAGTCGATGCAGCAGGAATAGAGTGGCGA
TTTCTTGGCTGCCTATTCGGCAGAACAC	ATTTTATTCGGCAGGTCGATGTTTGGGTCATT
TTTCTTGGCTGCCTATTCGGCAGAACAC

>NZ_CP022353|1|1|1710129-1710277|PILER-CR
TTCTTGGCTGCCTATTCGGCAGAACACATG	CAGTCGATGCAGCAGGAATAGAGTGGCGAT
TTCTTGGCTGCCTATTCGGCAGAACACATT	TTATTCGGCAGGTCGATGTTTGGGTCATTT
TTCTTGGCTGCCTATTCGGCAGAACACTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022353.1\|WP_089071597.1\|1705204_1705852_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187600
NZ_CP022353.1\|WP_089071596.1\|1703191_1704193_-\|ArsJ-associated-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|169599
NZ_CP022353.1\|WP_089072380.1\|1708691_1708802_-\|DUF3265-domain-containing-protein	unknown	unknown	gnl\|CDD\|288509
NZ_CP022353.1\|WP_089071604.1\|1712059_1714147_-\|hypothetical-protein	cas5f	cd09736_cas5f_CAS-I-F	gnl\|CDD\|187867
NZ_CP022353.1\|WP_089071598.1\|1705879_1706866_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022353.1\|WP_089071602.1\|1710371_1711010_-\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09739_cas6f_CAS-I-F:CAS-IV	gnl\|CDD\|187870
NZ_CP022353.1\|WP_060779563.1\|1717755_1718235_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022353.1\|WP_089071603.1\|1711021_1712053_-\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	cd09737_cas7f_CAS-I-F	gnl\|CDD\|187868
NZ_CP022353.1\|WP_000149587.1\|1702680_1703178_-\|phosphatase	unknown	unknown	gnl\|CDD\|350355
NZ_CP022353.1\|WP_089071606.1\|1719117_1720887_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341153
NZ_CP022353.1\|WP_089071599.1\|1707015_1707456_-\|DUF1240-domain-containing-protein	unknown	unknown	unknown
NZ_CP022353.1\|WP_089071594.1\|1700546_1701317_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP022353.1\|WP_089071595.1\|1701424_1702642_-\|organoarsenical-effux-MFS-transporter-ArsJ	unknown	unknown	gnl\|CDD\|340883
NZ_CP022353.1\|WP_029853851.1\|1715459_1716545_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224552
NZ_CP022353.1\|WP_001290352.1\|1718231_1718942_-\|DUF3800-domain-containing-protein	unknown	unknown	unknown
NZ_CP022353.1\|WP_089071600.1\|1707455_1708568_-\|type-VI-secretion-system-PAAR-protein	unknown	unknown	gnl\|CDD\|380263
NZ_CP022353.1\|WP_089071607.1\|1720886_1722392_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|280533
NZ_CP022353.1\|WP_000936745.1\|1704289_1704631_-\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|236654
NZ_CP022353.1\|WP_089071605.1\|1714149_1715361_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377670
NZ_CP022353.1\|WP_000061145.1\|1716597_1717590_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235264

Protein	Function_ID	Function_description	E-value
NZ_CP022353.1\|WP_089071597.1\|1705204_1705852_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	5.9232e-78
NZ_CP022353.1\|WP_089071596.1\|1703191_1704193_-\|ArsJ-associated-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|169599	PRK08955, PRK08955, glyceraldehyde-3-phosphate dehydrogenase; Validated.	0
NZ_CP022353.1\|WP_089072380.1\|1708691_1708802_-\|DUF3265-domain-containing-protein	gnl\|CDD\|288509	pfam11665, DUF3265, Protein of unknown function (DUF3265). This family of proteins with unknown function appear to be restricted to Vibrio.	0.00117196
NZ_CP022353.1\|WP_089071604.1\|1712059_1714147_-\|hypothetical-protein	gnl\|CDD\|187867	cd09736, Csy2_I-F, CRISPR/Cas system-associated RAMP superfamily protein Csy2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog.	3.98316e-20
NZ_CP022353.1\|WP_089071602.1\|1710371_1711010_-\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|187870	cd09739, Cas6_I-F, CRISPR/Cas system-associated RAMP superfamily protein Cas6f. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6f is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-F subtype; Possesses RRM fold; also known as Csy4 family.	1.17322e-48
NZ_CP022353.1\|WP_089071606.1\|1719117_1720887_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341153	cd17264, RMtype1_S_Eco3763I-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Escherichia coli O69:H11 07-3763 S subunit (S.Eco3763I) TRD2-CR2. Escherichia coli O69:H11 07-3763 S subunit (S.Eco3763I) recognizes 5'... TACNNNNNNNRTRTC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	3.32345e-92
NZ_CP022353.1\|WP_089071603.1\|1711021_1712053_-\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|187868	cd09737, Csy3_I-F, CRISPR/Cas system-associated RAMP superfamily protein Csy3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas7 ortholog.	6.93463e-150
NZ_CP022353.1\|WP_000149587.1\|1702680_1703178_-\|phosphatase	gnl\|CDD\|350355	cd14505, CDKN3-like, cyclin-dependent kinase inhibitor 3 and similar proteins. This family is composed of eukaryotic cyclin-dependent kinase inhibitor 3 (CDKN3) and related archaeal and bacterial proteins. CDKN3 is also known as kinase-associated phosphatase (KAP), CDK2-associated dual-specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), or cyclin-dependent kinase-interacting protein 2 (CIP2). It has been characterized as dual-specificity phosphatase, which function as a protein-serine/threonine phosphatase (EC 3.1.3.16) and protein-tyrosine-phosphatase (EC 3.1.3.48). It dephosphorylates CDK2 at a threonine residue in a cyclin-dependent manner, resulting in the inhibition of G1/S cell cycle progression. It also interacts with CDK1 and controls progression through mitosis by dephosphorylating CDC2. CDKN3 may also function as a tumor suppressor; its loss of function was found in a variety of cancers including glioblastoma and hepatocellular carcinoma. However, it has also been found over-expressed in many cancers such as breast, cervical, lung and prostate cancers, and may also have an oncogenic function.	3.48824e-60
NZ_CP022353.1\|WP_089071594.1\|1700546_1701317_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.88953e-84
NZ_CP022353.1\|WP_089071595.1\|1701424_1702642_-\|organoarsenical-effux-MFS-transporter-ArsJ	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.69412e-15
NZ_CP022353.1\|WP_029853851.1\|1715459_1716545_-\|hypothetical-protein	gnl\|CDD\|224552	COG1637, COG1637, Predicted nuclease of the RecB family [DNA replication, recombination, and repair].	0.000167042
NZ_CP022353.1\|WP_089071600.1\|1707455_1708568_-\|type-VI-secretion-system-PAAR-protein	gnl\|CDD\|380263	NF033420, T6SS_PAAR_dom, type VI secretion system PAAR protein. The PAAR domain is widespread, but this model represents a narrow clade that may occur in type VI secretion systems (T6SS), either free-standing or fused to a long extension. Effector domains of T6SS may be separate proteins, or may be fused to on of the tube or spike proteins: VgrG (spike), Hcp (tube), or this PAAR family (spike tip). Members of this family that have long extensions are likely to be T6SS effectors.	6.20244e-58
NZ_CP022353.1\|WP_089071607.1\|1720886_1722392_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	4.4588e-108
NZ_CP022353.1\|WP_000936745.1\|1704289_1704631_-\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|236654	PRK10141, PRK10141, DNA-binding transcriptional repressor ArsR; Provisional.	2.94409e-27
NZ_CP022353.1\|WP_089071605.1\|1714149_1715361_-\|hypothetical-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	5.97129e-11
NZ_CP022353.1\|WP_000061145.1\|1716597_1717590_-\|hypothetical-protein	gnl\|CDD\|235264	PRK04247, PRK04247, endonuclease NucS.	0.00140865

>NZ_CP022353.1|WP_089072380.1|1708691_1708802_-|DUF3265-domain-containing-protein
MTNGSRGTANARHFYYALVFVVTVLCGSLVIALAAP
>NZ_CP022353.1|WP_089071600.1|1707455_1708568_-|type-VI-secretion-system-PAAR-protein
MSKGVKVGDIGTDHDGFPPTPVTAGSPDVKFDGQPAARVGDPLAPHDKPKHPPHGRTIAAGSSTVMINGKPAAITGGAVSCGGVTIGSGTVNIGDTHQPASMSMLSASPRSVNQAQETASSTVAKNVSPQTLQIPQGSGYWPPYDFTKSKPLDVEYTQKVVDLAVMSLEEAEEFANNLWLEYNGKDTLDNSKKIWDGASNAKDAYQLAKGLGGMGVVAYVKPANGQDYIVIKGYKKHLKTLVKGNRWRANNPQVIQLGLGTKNMARNMLKVGIVVDIAFAIAINAVDVYVHDEKTMEDFVGRSGVDIVKGVVATGAGTIAAVVMATAGAPILVSGLLFAGISVGVGFALDWADNEFGISDSLVDQLKKGE
>NZ_CP022353.1|WP_089071599.1|1707015_1707456_-|DUF1240-domain-containing-protein
MKKIQIMGIVFFTLLLAGYLIIGAPSELALPFKPLEVRVRLLGYISYIALAIIPPLLLGGVCIMVHQICNPQRDVTSYGRAWSKIVYLVLVIGICALFARGYLGYQTANAGYVQCINESRTSSKNSWRVYAKDLSLCKPPSDIIGD
>NZ_CP022353.1|WP_089071598.1|1705879_1706866_-|hypothetical-protein
MFQGIMNGAGLIKEAIRALGKYPRMLIPLLLCWLVYAPLLVVFKFHIPWDNFDIITLLLVVFAAILLLSVIFSWSAFMLLELIRQIETDEERSISKAIRTSSINLVIGLPVVMGWAVIWFSLTLIEIILSRRSGGSDEEYNAKNVAKTLAGFQEFSLSGAFFEALKKGVRMTSFLIYPAIAWEKLGTAKSVKKGLGIARTHKSEFGAGFILTEFAATIVFLPPAVLFNVSDKFDISFSDPVWFGVMVYCAFAWSFSLFLEQMFVAELYLWHLIWEKEVDKARSKGKPEPKLEDVKRPSVMDSVADLYLTNVPKAANNTLNSQTPDGAA
>NZ_CP022353.1|WP_089071597.1|1705204_1705852_-|SDR-family-NAD(P)-dependent-oxidoreductase
MLRFERKIALVTGAAKGIGESIARHFAAEGAFVYVTDIDQDNGQQVASSLGQAARFALLDVRDEAAWQKLTKEIIDAHGRLDIVVNNAGITGFEEDFVPHDPENATLDAWRKVHETNLNGVFLGCKYAIKAMRSTGKGSIINISSRSGIVGIPTAAAYASSKAGVRNHTKSVALYCAQQNLNVRCNSIHPAAILTPMWEPVLGDIGYKANDFLYL
>NZ_CP022353.1|WP_000936745.1|1704289_1704631_-|metalloregulator-ArsR/SmtB-family-transcription-factor
MLPHQFFKLLADETRVRCLLMIAREEKVCVAELTEALNESQPKISRHLALLRASGVVVDIRQGQWVFYRISDQLPGWMRKQIQGLVESNCLKQEYQQDIQRLAEMTSRPQCCV
>NZ_CP022353.1|WP_089071596.1|1703191_1704193_-|ArsJ-associated-glyceraldehyde-3-phosphate-dehydrogenase
MAIKVGINGFGRIGRLALRASFDWPEIEFVQINDVAGDAATLAHLLEFDSVQGRWHHAVSIEADAILINGKRIRATQEKAIDAVDWSGCDVVIEATGKHRKGEFLNQYLAQGVKRVVVSAPVKEEGIANIVVGVNDHIFNPEQHRIVTAASCTTNCIAPVVKVIHEKLGIAQASFTTIHNLTNTQTILDAPHKDLRRARACGMSLIPTTTGSAKAIIEIFPDLKGKIDGHAVRVPLANASLTDIIFDVQRDTTVEEINQLLKQASENELKGILGFEERPLVSIDYQGDQRSTIVDALSTMVVGKRMVKIYAWYDNEMGYATRTAELVRKVGLA
>NZ_CP022353.1|WP_000149587.1|1702680_1703178_-|phosphatase
MTHPTWELPVADNQASLVLTPCPGTKGTPLSESIAQLKAQGVSAVVTALSHEEMEQHGVGELPAEVEKAGLQWFHAPIEDDCAPDAAFAQDWQQCSPALHQALSRGEKVALHCMGGSGRTGLLAAHLLLEKGWPLESIITQVQALRPGAFTKEVQVQYVHQIVKP
>NZ_CP022353.1|WP_089071595.1|1701424_1702642_-|organoarsenical-effux-MFS-transporter-ArsJ
MFMLSQLNAHVRQYMLVTFNYWNFTLTDGALRMLVVLYFYDLGYSSLAIASLFLFYEFFGVVTNLIGGWLGARLGLNRTMNIGLGLQIIALLMLAVPASWLTIPWVMAAQALSGIAKDLNKMSAKSAIKTLVPENAQGALFKWIAILTGSKNALKGAGFFLGGALLSLIGFQYAVATMAAVLALVFIGSVMSLKSDLGKAKNKPKFSDIFSKSASVNILSAARLFLFGARDVWFVIALPIYLGSVFGWDHSAVGGFLALWVIGYGVIQGFAPKITGSKSEHPPAGRAAIGWALALSLVTGLIAYGVQLQWHPEVVIIGGLMLFGAVFAVNSSLHSYLIVSYAKDDGVSLDVGFYYMANAMGRLIGTILSGWVFQLWGLAACLWVSFGFLVLTTLISFWLPNRTQE
>NZ_CP022353.1|WP_089071594.1|1700546_1701317_-|DeoR/GlpR-transcriptional-regulator
MTSTQRRDAILKYIQHHQSGSVNYFAEQFQVSEVTIRHDLNILEKKGCVTRCYGGALINAQFAFDQPLQDKKQLNQDIKSQLGAYAASLVEDGDTLILDSGSTTEQIAFHLTDKKQLKVMTNAINIAYHLANHDNIEVIVTGGLMRKNSYSLHGESGKALLGQFRFNKLFLGVDGFDKLAGVTTPHAGEASINRRMVEAAQMVIAVSDSSKFNRQSFCLIARPEQLDMLITDSGMPEDYRRELTAMGVDVRIVDAC
>NZ_CP022353.1|WP_089071602.1|1710371_1711010_-|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MSQRYYFLIRYTNANADYGLLAGRCISQMHLFMVNHHQAMNRVGVSFPDWNESSVGQTIAFVSEDKEMMIGLSFQPYFSLMVNEGLFEISSVYEVPDTSEEVRFVRNQTIGKNFLGSKKRRIKRSMARAELFGIQQSLPVTNEDRAIDSFHQIPISSCSSRQDYILFIQKELADERAESGFNSYGFATNQEKRATVPDLRFNPFDEDSFLVK
>NZ_CP022353.1|WP_089071603.1|1711021_1712053_-|type-I-F-CRISPR-associated-protein-Csy3
MELCTQLNYVRSLSAGKAYFYYLSESGEMCPLNVDRTRLRAPKGSYSEAYKGNKFVEKNIAPQDLAYSNPQFIEECYVKPGVDEIYCAFSLRIRANSLTPDICSDDEVRSKLSMFAKIYKELNGYKELANRYAKNILLGTWLWRNRECRNITIEVTTSELDTFVVEHAQKLSWYGHWDGDSTECLERLTAYLERALSDPTEYFYMDVKAKLRVGWGDEVYPSQEFLDSREDGIPTKQLATVELLRGKETVAFHGQKVGAALQSIDDWWHEEADKPLRVNEYGADREYVIARRHVTYGNDFYQLLRNTENWIESMTASESIPNDVHFIMSVLIKGGLFNCAKAN
>NZ_CP022353.1|WP_089071604.1|1712059_1714147_-|hypothetical-protein
MTKLSDLLAIEDEAIKQTALKKMFMPYTEDVCVDGYEQETLTILLNLSSSHQADRCSDWLDVARAQRYLKDRENLDASLAEIQWFHTHNLKFPDCRVKDQRIIARPLSTAEEFISSAVLDQRLGWAHNSAVYRHTLWLLNPFKWQSQPVCILSLIQQKNPVWLDLLKEFGLDVKSLAHLQSAIEEQLPENSFPDSVSTYSKQLRFPWGDDYVSIPPVVSHALQCELEIRARSPENKLSFVSSSLPNSASIGNLCGSLGGYMRVLNYPLGVKQAKGGTLTENRQKSGHYFDDYQVTNAKICQVLNRLIGSEPSKTQRQRERARKVRSKILRKQIALWMLPLIELRDIAESEPNQQQLEHDDTLAQAFLSLPEWELGSLASEFNRRLHLTFQNNMYSAKFAYHPKLMQVAKAQVTWVLEQLSKPINNQDTVTGEQYIYLSSMRVQDAVAMSNPCLCGVPSLTAIWGFMHDYQRQFNQLVNNDSPVEFSSFAFYVRNENIQSTAKLTEPNSVAKARTVSNAKRPTIRSERLSDLEIDLVIRVHSESRISDFRSALKTALPVAFAGGALYQPQLSTQIEWLRTFTGRSELFHVLKGLPAYGRWLYPSEKQPTNFDELERLLTQDDDNLPVSLGYHLLEHPTKRDNVITGCHAYAENAIGLAKRINPIEVRFSGLDHFLNHAFWSIECSSETILIKNHRD
>NZ_CP022353.1|WP_089071605.1|1714149_1715361_-|hypothetical-protein
MKMDIQLYPDESLESFLLRLSQEQGYERFSHFAEDIWFDTMEQHEAIAGAFPLELNRINIYHAQTTSQMRVRVLIHLENQLKLNNFGTLRLALSHSKAQFSPEYKAVHRFGSDYPFVFLGQRFTPICPLCISEAPYIRQQWQFLSQQACERHGCKLLHHCPECQSRLEYQTTESISQCECGFELRNSPIEDAPVAALLVARWLSGNDSKPLGLLKAEMTLSERYGFLLWYVNRYGDIENISFESFVEYCSCWPRVLKEELDELVNKADLIRIKDWKKTFFNEVFGALLKDCRQLPSRQLERNSVLTQVLAYFTKLMAAIPSSSKGNVGDVLLSPLEASTLLSCTTDEVYRLYEFGEIKAAIRPRMHTKIASHESAFTLRSVIETKLTRMCSENDGLSVYLPEW
>NZ_CP022353.1|WP_029853851.1|1715459_1716545_-|hypothetical-protein
MAIEQGIWKIGDKPQRLKPISMATEELLEKQILHDISLLNKDWLLIGHQVRTGFDKRIDLLALDSNGSTIVIELKRDKTPRDVVAQAMDYASWVVGLSPDDIEELYFSFAKSNGLTQSLEVAFNQKFGVGLADVELNESHHLVIVASELDASTERIINYLNEYSRLSINAVFFSAFEDMGNLYLSRAWFIDPDETKDLAISKQKKEQWNQEFYVSFGHDQYRHWEDARKYGFVAGGHGLWYSKTLSMLAEGDRIWVNIPKTGYVGVGIVTGEKVRLEHHQFEDFSGKTLPELETAGDYACCSSLSDDDAQYLVPVKWIKTLPQQSAFSEIGLFGNQNTVCKPRAAKWVHTVERLKETWSID
>NZ_CP022353.1|WP_000061145.1|1716597_1717590_-|hypothetical-protein
MSLYNISNKNLTALTQTTFAAEGLQERQDLQEALKGCIDAIAPDCLVISEEFSDWEDSRRRIDLLAIDRNANLVVIELKRDEIGAHMELQALRYAAMISTMTFDKACEYFERYIAKEGLEINARETILEFVDLDENSLDDFGNDVRIVLASADFGKELTTSVLWLRDKGIDISCVRLTPYRYKDDVLINAEQIIPVPEVEAYQVKFREKQAEQRTSKNGQRDYSKYRFNGQVYNKRKLALAVITHWINDKQPMSLAEVQRYLNSFNLPRAVSLFEHIADKHLNRYHSSESDRLMLVSGEQIAISNQWGDNIPNLLQAMEPYGYEIVKVEN
>NZ_CP022353.1|WP_060779563.1|1717755_1718235_-|hypothetical-protein
MTTAWLPDLVMMEDYNHNWEQYLAAIYSFFEADFVHSKPEFQGRRLGLKRYPEYDGKSATFWHMTSTGDDETERVPDFRRCERIRWPRPIIENDQHESLKVWTEPKGKNQRVHIWCEEEGYLVVLDDRGEYILPWTAFYIEREHQRKKYNKRWEKYKDK
>NZ_CP022353.1|WP_001290352.1|1718231_1718942_-|DUF3800-domain-containing-protein
MSEIYNVYCDESCHLENDGIGVMALGALWCPLSKRAEIAKRIREIKVRHGLKAEFEIKWTKVSNSKLAFYLDIIDYFFDDDDCHFRGLVVPDKTVLDHPRFGQDHDDWYYKMYFFMLKTIFDPQSKYRVYIDIKDTLGHEKIERLHDVMCNSHYDFSKSIIERMQRIHSHEAEQLQMADLLIGALGYLHRGLDGNKAKLALIERIKDRSGYKLTQNTLLRENKFNLFVWTGQGGFA
>NZ_CP022353.1|WP_089071606.1|1719117_1720887_-|restriction-endonuclease-subunit-S
MSAEKLITDHIDIWTSAVQAKSSSGRGSGKKREIYGIKKLRELILELAVRGKLVPQDPSDEPASVLLERIAAEKAQLVKDGRLKKQKPLPNVEGDEFLFELPNGWDWTRLGNISEIAPKNPHFDDNELVSFVPMPLISNSYKGTHSFEERKWGEVKKGYTHFADGDIAIAKITPCFENSKAAVFSGLINGVGTGTTELHVARPIEGTSDPLFILLYLKSPMFLKVGETKMTGSAGQKRVPKDFFAGNPLPLPPLQEQHRIVAKVDELMALCDQLEQQTEASLDAHQVLVETLLATLTNSQDATELMANWARISEHFDTLFTTEQSIDQLKQTILQLAVMGKLVPQDPTDEPAAKLLERIAEEKAQLVKEKKIKKQKALPPIAEDEKPFELPKGWEWVKFGELSEFINGDRSKNYPNKDEYVDQGIPWINTGHIEPDGTLTTKDMNFITKEKFDTLRSGKIIHTDLVYCLRGATFGKTAFVSPYVEGAIASSLMIIRPYNVSLREFFYTYLISPFGRSQIFRFDNGSAQPNLSANSVMLYAFPCPPIEEQIRITTKVRELFLMCDQLKQRLRDSQQTQLQLTDAIVEQAL
>NZ_CP022353.1|WP_089071607.1|1720886_1722392_-|type-I-restriction-modification-system-subunit-M
MSISSVIKSIQDIMRKDAGVDGDAQRLGQLSWLLFLKVFDAQEEELELELDDYKAPINERYLWRNWAADAQGITGDKLLEFVNDDLFYNLKNMAAPVDTNPRGYVVKEAFSDAYNYMKNGTLLRQVINKLNEIDFTDTDERHLFGDIYEQILRDLQSAGNAGEFYTPRAVTRFIVDRLDPKLGENVFDPSCGTGGFLTCAINHINAHYKPKTSEQYETFQKQFHGVEKKQLPHLLCITNMMLHGIEVPSQIKHDNTLNKPLSNWDSNINVIATNPPFGGTEEDGIEKNFPAEMQTRETADLFLQLIIEVLEPGSDTKSGGRAGVVLPDGTLFGEGVKTKIKKLLTEECNLHTIVRLPNGVFNPYTGIKTNILFFTKGKPTKEVWFYEHPYPEGVKNYSKTKPMKFEEFQAEIDWWGKEEDGFASRVENNHAWKVSIDEIIARNFNLDIKNPYQGEVVSHDPDELLESYKTQQQEINELRNQLKDILGNALSSSAQAADEVK

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Crispr_ID: NZ_CP022353_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022353_2

2375251-2375494

Orphan

Consensus_repeat	Method
AAAATGTGCCTCCTTAGCTCAGTCGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP022353_2

>merge|NZ_CP022353|2|2375251-2375494|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAATTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCAAAGACACAATAAAAATTGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

>NZ_CP022353|2|2|2375251-2375494|PILER-CR
TGTGCCGGCTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGG	TCGCCAGTTCGATTCCGGCAGCCGGCACCACTTAAAA
TTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTG	TCGGTGGTTCGATTCCGCCTCGAGGCACCACTATTAAAAGTTGTGCCAAAGACACAATAAAAAT
TGTTCCTCCTTAGCTCAGTCGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022353.1\|WP_000005581.1\|2371483_2372203_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP022353.1\|WP_089071986.1\|2372443_2373505_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NZ_CP022353.1\|WP_089071996.1\|2385425_2386235_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	unknown	unknown	gnl\|CDD\|234673
NZ_CP022353.1\|WP_089071999.1\|2386894_2387380_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182143
NZ_CP022353.1\|WP_089071994.1\|2384147_2384963_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP022353.1\|WP_089071992.1\|2381856_2383152_+\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NZ_CP022353.1\|WP_089071991.1\|2379440_2381804_+\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158
NZ_CP022353.1\|WP_089071988.1\|2375782_2377408_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP022353.1\|WP_089071982.1\|2367222_2367780_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP022353.1\|WP_089071995.1\|2385034_2385415_+\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP022353.1\|WP_089071983.1\|2367779_2368070_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP022353.1\|WP_000805057.1\|2370452_2371373_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NZ_CP022353.1\|WP_089071985.1\|2369212_2370388_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NZ_CP022353.1\|WP_000124738.1\|2373518_2373791_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NZ_CP022353.1\|WP_089071987.1\|2373892_2375020_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NZ_CP022353.1\|WP_055028323.1\|2368616_2369219_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP022353.1\|WP_089071993.1\|2383141_2384134_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NZ_CP022353.1\|WP_089071998.1\|2386384_2386882_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP022353.1\|WP_089071990.1\|2378439_2379294_-\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NZ_CP022353.1\|WP_089071984.1\|2368115_2368547_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616

Protein	Function_ID	Function_description	E-value
NZ_CP022353.1\|WP_000005581.1\|2371483_2372203_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	4.57395e-111
NZ_CP022353.1\|WP_089071986.1\|2372443_2373505_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NZ_CP022353.1\|WP_089071996.1\|2385425_2386235_+\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	gnl\|CDD\|234673	PRK00166, apaH, symmetrical bis(5'-nucleosyl)-tetraphosphatase.	1.48019e-169
NZ_CP022353.1\|WP_089071999.1\|2386894_2387380_-\|hypothetical-protein	gnl\|CDD\|182143	PRK09917, PRK09917, threonine/serine exporter.	1.27528e-66
NZ_CP022353.1\|WP_089071994.1\|2384147_2384963_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	6.51524e-146
NZ_CP022353.1\|WP_089071992.1\|2381856_2383152_+\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	6.13628e-155
NZ_CP022353.1\|WP_089071991.1\|2379440_2381804_+\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0
NZ_CP022353.1\|WP_089071988.1\|2375782_2377408_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	4.65744e-59
NZ_CP022353.1\|WP_089071982.1\|2367222_2367780_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	6.07266e-12
NZ_CP022353.1\|WP_089071995.1\|2385034_2385415_+\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	1.83204e-74
NZ_CP022353.1\|WP_089071983.1\|2367779_2368070_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	3.53479e-60
NZ_CP022353.1\|WP_000805057.1\|2370452_2371373_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NZ_CP022353.1\|WP_089071985.1\|2369212_2370388_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NZ_CP022353.1\|WP_000124738.1\|2373518_2373791_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	5.47988e-59
NZ_CP022353.1\|WP_089071987.1\|2373892_2375020_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	2.61818e-156
NZ_CP022353.1\|WP_055028323.1\|2368616_2369219_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	2.99947e-128
NZ_CP022353.1\|WP_089071993.1\|2383141_2384134_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NZ_CP022353.1\|WP_089071998.1\|2386384_2386882_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	2.59907e-92
NZ_CP022353.1\|WP_089071990.1\|2378439_2379294_-\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	3.49368e-153
NZ_CP022353.1\|WP_089071984.1\|2368115_2368547_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	3.5861e-65

>NZ_CP022353.1|WP_089071987.1|2373892_2375020_+|membrane-bound-lytic-murein-transglycosylase-MltC
MRKLVLCITALLLSGCSREFIEKIYDVDYEPTNRFAKNLAELPGQFQKDTAALDALINSFSGNIEKRWGRRELKIAGKNNYVKYIDNYLSRSEVNFTEGRIIVETVSPIDPKAHLRNAIITTLLTPDDPAHVDLFSSKDIELKGQPFLYQQVLDQDGQPIQWSWRANRYADYLIANHLKVKQVDFKKAYYVEIPMVKDQIDIRGYKYANIVRKASRKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNRSGEPSPEYLFNPENNIDTGTAYFYILKNRYLKEVRHPTSLEYSMISAYNGGTGGVLNTFSNDRQRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKKEFNAG
>NZ_CP022353.1|WP_000124738.1|2373518_2373791_+|oxidative-damage-protection-protein
MARTVFCTRLQKEADGLDFQLYPGELGKRIFDNICKEAWAQWQTKQTMLINEKKLNMMDPEHRKLLEQEMVNFLFEGKEVHIEGYTPPAK
>NZ_CP022353.1|WP_089071986.1|2372443_2373505_+|A/G-specific-adenine-glycosylase
MTPFAQAILTWYDAYGRKNLPWQQNKNAYRVWLSEIMLQQTQVATVIPYFARFLERFPTVHALAAAPQDEVLHFWTGLGYYARARNLHKAAKMVVSEYGGEFPTDLEQMNALPGVGRSTAAAVLSSVYKKPHAILDGNVKRTLARCFAVEGWPGQKSVENQLWHYAEMHTPKVDVDKYNQAMMDMGAMICTRSKPKCSLCPVESFCLAKQQGNPQEYPGKKPKTDKPVKATWFVMLYHDNAVWLEQRPQSGIWGGLYCFPQSEIANIQTTIDQRAIGDSTITSQKTLIAFRHTFSHYHLDITPILLQLSRKPDIVMEGSKGLWYNLSQPDEIGLAAPVKQLLHSLPFDIDSHI
>NZ_CP022353.1|WP_000005581.1|2371483_2372203_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVITQEYTEDGKVLRRIRSFVRREGRLTKGQEAAMKECWPTMGIDYQPELLDWQQVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFLGIEVHSPGVGACLASAREAGVTNLRVMCHDAVEVFAHMIPDNSLHTLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIIGSGVFHMATDWENYAEHMIEVMNQAPGFANLATDGDYIPRPDERPLTKFEQRGHRLGHGVWDIKYQRTA
>NZ_CP022353.1|WP_000805057.1|2370452_2371373_-|glutaminase-B
MKPTAEILASIIEEVRPLTGQGKVADYIPALAKVPSEKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPLIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIF
>NZ_CP022353.1|WP_089071985.1|2369212_2370388_+|radical-SAM-family-heme-chaperone-HemW
MLTPPPLSLYIHIPWCVQKCPYCDFNSHAQKGEIPEQEYLDALLEDLDRDIERYQLKGDPRLLHSIFIGGGTPSLISAEGIARLLQGVAKRIAFKPEIEITMEANPGTIEAQRFAGYRTAGVTRISIGVQSFDPEKLARLGRIHGQQEAVRAAQLAHQIGLNSFNLDLMHGLPDQTPEQALADLDQAITLNPPHLSWYQLTIEPNTLFYSKPPKLPDEDALWDIFELGHQKLSDAGYVQYEISGYSKPGYQCQHNLNYWRFGDYLGIGCGAHGKLSFTDGRIVRTTKTKHPRGYLAALNNLAKAYLDSEQLVADQDKPFEFFMNRFRLIEPCPKADFTATTGLPIDVIRPTLDWALNEGYLSEDDQHWQITEKGKLFLNDLLEAFMADDEE
>NZ_CP022353.1|WP_055028323.1|2368616_2369219_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFDVVAQSEFNVPEVAETGTTFIENAIIKARHAAQITGLPAIADDSGLEVDYLNGAPGIYSARYAGEHASDGDNLNKLLAAMQDVPDDQRSARFHCVLVLMRHADDPTPIVCHGKWEGKILTSPHGSNGFGYDPIFWVPEENCASAELEPVRKKQLSHRGKALQKLFKAIEEQRTC
>NZ_CP022353.1|WP_089071984.1|2368115_2368547_+|DUF4426-domain-containing-protein
MRKWMMSLLLTLLALPASAEQQKTIKDIEVHYSAFNSTFLTPKVASSYQLTRNGYTAILNISVLDRASLGKPATEVKLTGHAKNLIGNLRELSFKQVNEGNAIYYLAEVPISNEEMLTFDINVDAGLKGAGKLTFSQKFYTEQ
>NZ_CP022353.1|WP_089071983.1|2367779_2368070_+|YggU-family-protein
MAAVWREGDDLLLRLYIQPKASRDSIVGLHGEELKVAITAPPIDGKANAHLSKYLAKLCKVAKGSVVIEKGELGRHKQVRILQPSQIPADIAALIE
>NZ_CP022353.1|WP_089071982.1|2367222_2367780_+|YggT-family-protein
MNSLSFLINTLFDLYIMVVILRIWLQAARADFYNPFSQFIVKVTQPVVGPLRRVIPSIGSIDLATIVFAYVLCVLKFMALVLLASSGSVSFSADFLFLGLLSLIKAAGGLLFWVLLVRAILSWVSQGRSPIEYVFNQLTEPMLAPIRRIIPVMGGFDLSILVLFIVLQFANFLMGDVIGPIWYQL
>NZ_CP022353.1|WP_089071988.1|2375782_2377408_+|methyl-accepting-chemotaxis-protein
MKLKTQAYLLSAIILAALLALTATGLWTLRVASNFDNKARVTELFSSAYSILTEVEKLAKEGKMSEPEAKALATRLMRNNLYKDNEYVYVADENMTFVATPLDPQLHDTSFHDFKDGKGNSVGRLIQDVLHNQSGKLVEYTWTQTQADGSIEEKLSIARKTPHWGWVVGTGIGFNEVNARFWSTAQWQLSLCVVIAVAILSLLLIAIRKILLIIGGEPNEVRSAVQSVAQGRIRREFTVKAPKESIYGAVQQMSSSLADLVAKLEQSMVALRSELAGAGTRAKSIAELTDNQQQSTAMIATAMTEMASSANQVADSARDTAFNTDQADQQSQHTQKLIHNTVSNIQGLATQLQTASTAVADLDLDVKNIAKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRNLAGRTQTSTKEIQQMIHNLQEGSRNAIQTIQICGQTSQSSVQESENAASALALIVSALESVSSMSHQIATAAAEQTQVSDDIARRINMIEESGSKLSRVVMESHNSTQTLTKLARELEQWAAHFEVTR
>NZ_CP022353.1|WP_089071990.1|2378439_2379294_-|co-chaperone-DjlA
MHIFGKILGAFFGFLFGGPFGAIFGIFLGHQFDKARRLNQAGFQSGKFGAGPSQAERQEEFFKAAFSVMGHVAKAKGQVTKEEIQLATIMMDRMNLTLEQKRAAQDAFRDGKESDFPLEQVLERVKIATGGRFDLLQFFLELQVSSAFADGDVHPSERQVLHRIARGLGFSSEQLERRLRMQEAAFRFQQGGGFGGSQQQSHSGQQWQQPSSRHQLADAYEVLGVSESASAQEVKRAYRKLMNEHHPDKLMAKGLPPEMMNVAKEKSQQIQHAYELIRKEKGIK
>NZ_CP022353.1|WP_089071991.1|2379440_2381804_+|LPS-assembly-protein-LptD
MYNPMSCFSRTFLAASISAALFAPQIQAEASVDDNRAQLPNGEQCLVNQPEPANPGQQPINVEADKLEAINGQKATYSGNVVVVQGKKRIAADNVTLHQQENVVVAEGNVQFSDGEIKTHSTKATNHLNTDEMTLENTRYQFLCEPGRGEAVYVSKTGKAVYEIEDGSITSCPDGDNAWRMRASSIDVDQNEEIATFYNPRLEVQNVPVFYLPYLTVPIGDTRKTGFLYPTASYGSRDGYEFEVPIYWNLAPNYDLETTFNYMQKRGTQLNSVFRYLTDFGAGQIKSEFLPDDQLHAEQGDRWAFQYEHNGIFQQAWKFEIDYSKVSDINYFSDLDSGVGNREDGQLIQEGRATYRSDNWDSALLVRDFQLLTKDTTSTNLPYRLMPQLSYNYYAPETMKYLDLDLVSHVSRFETDARGKPSATRVHIEPGLKIPFSNTWGNWTTEARVLGTYYQQDLDKTTDAKLEESVTRVIPELRSVAGIVLERDTVLLDSYTQTLEPKIQYLYVPEKYQDNIGLYDSTLLQTDYYGLFRSRKYSGVDRIESANQVSYGASTRFFDSSYKERLNIAFGQIFYLDSKFNPSNKNPDSTSEKTSYSAWAVEMDFNFADYLFYHGGIQYDIDSQAIQLGNSSLEYRVASGYIQGNYRYVAKDYIRNTVGDSITNIDDITRDGISQAGILAGYQLSRKWSASGQYYYDLTTDEALEWLANLTYTSDCWYVGFTYSNQLKSWNGNFVTDPYATPIYENNFSFNVGIIGFGTSIGAGSSMTGVDSAGNSLGYGRPFFLNN
>NZ_CP022353.1|WP_089071992.1|2381856_2383152_+|peptidylprolyl-isomerase-SurA
MKLWKPTLISVISALTLFNAHAEPKQLDSVAVIVNSGVILQSDVDSALKTIKANAKQNQQPLPQETLLREQVLEKLIIDTLQQQEADRIGVKIDDNRLNEAIKEIAKNNQQTQEQLIASVAQEGLTYPEFREQVRKEMAASDARNALVRRRINILPAEVDTLAELLAHETDATVQYKISHIQLRVDDGQDKSAAETLANKLVNDLKSGADFAQMAYAYSKGPKALQGGDWGWMRKEEMPTIFADQIKMQNKGSIIGPFRSGVGFHILKIDDVKGLETVAVTEVNARHILIKPTIILSDEGAQKQLNEFVQRIKKGEVTFAELAQQYSQDPGSAAQKGELGYQTPDLYVPEFKHQIEILPVGQISEPFKTVHGWHIVEVLDRREVDRTDSALKNKAYRILFNRKFNEEAGAWLQELRASAFVEVLKDEQDEQ
>NZ_CP022353.1|WP_089071993.1|2383141_2384134_+|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRAAQLGIQVKLLDYQRDNPVQAQQAGTLLVEHISLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERLEQIVHILHKDLVEKFAIAEPKIYVCGLNPHAGEDGVLGMEEIETITPTLQRLREQYGMQLVGPLPADTIFSEKYLQQADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGTGQADAGSFWTALAYAIELVDKKAK
>NZ_CP022353.1|WP_089071994.1|2384147_2384963_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MRNDVHLGHKARKRFGQNFLNDPYIIDGIVSAINPKPGQNLVEIGPGLGAITEPVGREVDKFTVIELDRDLAERLRNHPELASKLTIHEGDAMRFDFKQLVKPNNKLRVFGNLPYNISTPLMFHLFEFHRDIQDMHFMLQKEVVNRLAAGPGTKAYGRLTVMAQYYCKVVPVLEVPPTAFVPPPKVDSAVVRLMPYEDLPHPATSLEWLDRVVREGFNQRRKTVRNCYKGLAEPETLETLGINPGMRPENLTLAQFVALANWLDATHKTHA
>NZ_CP022353.1|WP_089071995.1|2385034_2385415_+|Co2+/Mg2+-efflux-protein-ApaG
MDVSLPCIKIQVQTRYIEEQSNPEYQRFVFAYLITIKNLSTQTVQLMSRRWLITDADGKQTVVEGDGVVGEQPRIKANDEYTYSSGTALDTPVGVMQGQYLMIDEQGESFTVEIEPFRLAVPHVLN
>NZ_CP022353.1|WP_089071996.1|2385425_2386235_+|symmetrical-bis(5'-nucleosyl)-tetraphosphatase
MANYIVGDIQGCFDELQQLLKQAEFNSQLDTLWFAGDLVARGPKSLETLRFAYQLGDAARVVLGNHDLHLLSVALGHHPAKRRDQTQAILDAPDAAPLLDWLRQQPLLAEHKEFVLCHAGISPQWDLATARQAAQEVESVLRSPEWSTLIEQMYSDQPDAWHPTLQGIDRLRYIVNAFTRMRFCFPDGRLDMQCKLPPQEVTDGSLLPWFQLPQRIALEKTVIFGHWAALEGYVSETVIGLDTGCVWGGTLTMLRWEDKHYFSQAALPT
>NZ_CP022353.1|WP_089071998.1|2386384_2386882_-|type-3-dihydrofolate-reductase
MMVSMIAAMADQRIIGKDNQMPWHLPADFAWFKRCTLGKPVVMGRKTYQSIGRPLPGRHNIVISRDASLQIEGVDVVTSIEAALAKAGEVDEVMIIGGGSLYAACLPMAHKLYITEIHAELDGDTQFPEWGSDWLERSREHYPADEKNAYGMDFVIFERQYPLPT
>NZ_CP022353.1|WP_089071999.1|2386894_2387380_-|hypothetical-protein
MGVVMLSWDLFFGLLNDMFFAAIPAVGFALVFNVPVPALKYCALGGALGHGSRYLMMHFGVPIEWATFFAATLVGMVGVYWSRRFLAHPKVFTVAALIPMVPGVFAFKAMIALVEINHVGFSPELMEALLENFLKAMFIIAGLAVGLAVPGLLFYRRKPII

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022353_1	1.1\|1710156\|32\|NZ_CP022353\|CRISPRCasFinder	1710156-1710187	32	NZ_CP043555	Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence	9130-9161	0	1.0
NZ_CP022353_1	1.3\|1710159\|30\|NZ_CP022353\|PILER-CR	1710159-1710188	30	NZ_CP043555	Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence	9130-9159	0	1.0
NZ_CP022353_1	1.2\|1710216\|32\|NZ_CP022353\|CRISPRCasFinder	1710216-1710247	32	NZ_CP053818	Vibrio cholerae strain SA7G plasmid pSA7G1, complete sequence	15618-15649	2	0.938
NZ_CP022353_1	1.4\|1710219\|30\|NZ_CP022353\|PILER-CR	1710219-1710248	30	NZ_CP053818	Vibrio cholerae strain SA7G plasmid pSA7G1, complete sequence	15620-15649	2	0.933
NZ_CP022353_2	2.1\|2375300\|37\|NZ_CP022353\|PILER-CR	2375300-2375336	37	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23560	4	0.892
NZ_CP022353_2	2.1\|2375300\|37\|NZ_CP022353\|PILER-CR	2375300-2375336	37	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35428-35464	4	0.892
NZ_CP022353_1	1.3\|1710159\|30\|NZ_CP022353\|PILER-CR	1710159-1710188	30	NZ_CP043518	Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_06, complete sequence	22447-22476	7	0.767
NZ_CP022353_1	1.4\|1710219\|30\|NZ_CP022353\|PILER-CR	1710219-1710248	30	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	1938792-1938821	9	0.7
NZ_CP022353_1	1.4\|1710219\|30\|NZ_CP022353\|PILER-CR	1710219-1710248	30	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	1938790-1938819	9	0.7
NZ_CP022353_1	1.4\|1710219\|30\|NZ_CP022353\|PILER-CR	1710219-1710248	30	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	212162-212191	9	0.7
NZ_CP022353_1	1.2\|1710216\|32\|NZ_CP022353\|CRISPRCasFinder	1710216-1710247	32	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	1938792-1938823	11	0.656
NZ_CP022353_1	1.2\|1710216\|32\|NZ_CP022353\|CRISPRCasFinder	1710216-1710247	32	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	1938790-1938821	11	0.656
NZ_CP022353_1	1.2\|1710216\|32\|NZ_CP022353\|CRISPRCasFinder	1710216-1710247	32	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	212160-212191	11	0.656

1. spacer 1.1|1710156|32|NZ_CP022353|CRISPRCasFinder matches to NZ_CP043555 (Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

atgcagtcgatgcagcaggaatagagtggcga	CRISPR spacer
atgcagtcgatgcagcaggaatagagtggcga	Protospacer
********************************

2. spacer 1.3|1710159|30|NZ_CP022353|PILER-CR matches to NZ_CP043555 (Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

gcagtcgatgcagcaggaatagagtggcga	CRISPR spacer
gcagtcgatgcagcaggaatagagtggcga	Protospacer
******************************

3. spacer 1.2|1710216|32|NZ_CP022353|CRISPRCasFinder matches to NZ_CP053818 (Vibrio cholerae strain SA7G plasmid pSA7G1, complete sequence) position: , mismatch: 2, identity: 0.938

attttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
attttattcggtaggtcgatgtttggatcatt	Protospacer
***********.**************.*****

4. spacer 1.4|1710219|30|NZ_CP022353|PILER-CR matches to NZ_CP053818 (Vibrio cholerae strain SA7G plasmid pSA7G1, complete sequence) position: , mismatch: 2, identity: 0.933

tttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
tttattcggtaggtcgatgtttggatcatt	Protospacer
*********.**************.*****

5. spacer 2.1|2375300|37|NZ_CP022353|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatat	Protospacer
.*********************.***********. *

6. spacer 2.1|2375300|37|NZ_CP022353|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

taggtcgccagttcgattccggcagccggcaccactt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatc	Protospacer
******.***************.*********** *.

7. spacer 1.3|1710159|30|NZ_CP022353|PILER-CR matches to NZ_CP043518 (Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_06, complete sequence) position: , mismatch: 7, identity: 0.767

gcagtcgatgcagcaggaata--gagtggcga	CRISPR spacer
gcagtcgttgcagcaggaataacaagcaac--	Protospacer
******* *************  .**...*

8. spacer 1.4|1710219|30|NZ_CP022353|PILER-CR matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.7

tttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
ccaattcggcacgccgatgtttgggtgggc	Protospacer
.. ******** *.************ . .

9. spacer 1.4|1710219|30|NZ_CP022353|PILER-CR matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.7

tttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
ccaattcggcacgccgatgtttgggtgggc	Protospacer
.. ******** *.************ . .

10. spacer 1.4|1710219|30|NZ_CP022353|PILER-CR matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.7

tttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
ccaattcggcacgccgatgtttgggtgggc	Protospacer
.. ******** *.************ . .

11. spacer 1.2|1710216|32|NZ_CP022353|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.656

attttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
ggccaattcggcacgccgatgtttgggtgggc	Protospacer
. .. ******** *.************ . .

12. spacer 1.2|1710216|32|NZ_CP022353|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.656

attttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
ggccaattcggcacgccgatgtttgggtgggc	Protospacer
. .. ******** *.************ . .

13. spacer 1.2|1710216|32|NZ_CP022353|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.656

attttattcggcaggtcgatgtttgggtcatt	CRISPR spacer
ggccaattcggcacgccgatgtttgggtgggc	Protospacer
. .. ******** *.************ . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

456928 : 463547

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_089070822.1\|456928_458062_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.4e-64	40.4
WP_080299252.1\|458070_459324_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.7e-100	49.7
WP_000543544.1\|459423_459873_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_089070823.1\|459898_461002_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.7e-43	32.8
WP_000493874.1\|461006_461660_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.2e-31	38.2
WP_001122865.1\|461700_462810_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	6.7e-64	39.8
WP_000864130.1\|463076_463547_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	6.8e-34	48.7

DBSCAN-SWA_2

2048275 : 2055341

Anguillid_herpesvirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001162850.1\|2048275_2048704_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.0e-20	38.4
WP_000107234.1\|2048781_2050071_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	6.5e-34	34.0
WP_000872176.1\|2050290_2050485_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_001124187.1\|2050532_2050871_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_089071821.1\|2050884_2052735_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	2.6e-105	40.9
WP_069503737.1\|2052758_2053274_-	co-chaperone HscB	NA	NA	NA	NA
WP_089071822.1\|2053322_2053646_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	3.0e-25	50.5
WP_000331703.1\|2053706_2054090_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	5.4e-53	78.2
WP_000775253.1\|2054126_2055341_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	1.1e-32	30.5

DBSCAN-SWA_3

2289325 : 2296576

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001279365.1\|2289325_2290213_+	cysteine synthase CysM	A0A1X9I5K7	Streptococcus_phage	4.1e-56	41.1
WP_089072387.1\|2290479_2293068_+	DNA mismatch repair protein MutS	A0A1V0SJ67	Klosneuvirus	1.4e-32	25.7
WP_089071941.1\|2293146_2294157_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	6.0e-35	34.2
WP_089071942.1\|2294230_2295166_-	murein hydrolase activator NlpD	D7RWE0	Brochothrix_phage	4.6e-05	34.7
WP_089071943.1\|2295165_2295792_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.0e-36	52.1
WP_001883363.1\|2295784_2296576_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	8.4e-69	51.6

DBSCAN-SWA_4

2406845 : 2454838

Leptospira_phage(40.0%)

transposase,integrase,protease

attL 2401732:2401746|attR 2466494:2466508

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2401732:2401746	attL	NA	NA	NA	NA
WP_089072008.1\|2406845_2408291_-\|protease	metalloprotease TldD	NA	NA	NA	NA
WP_089072009.1\|2408290_2409118_-	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_089072010.1\|2409126_2413002_-	TIGR02099 family protein	NA	NA	NA	NA
WP_089072011.1\|2413014_2414484_-	ribonuclease G	NA	NA	NA	NA
WP_089072012.1\|2414509_2415127_-	septum formation inhibitor Maf	NA	NA	NA	NA
WP_089072013.1\|2415069_2415558_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_089072014.1\|2415544_2416435_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_000473772.1\|2416491_2417535_-	rod shape-determining protein	F2Y0P3	Organic_Lake_phycodnavirus	2.1e-06	20.4
WP_089072015.1\|2417702_2421857_-	MSHA biogenesis protein MshQ	NA	NA	NA	NA
WP_089072016.1\|2421846_2422278_-	MSHA biogenesis protein MshP	NA	NA	NA	NA
WP_089072017.1\|2422243_2423014_-	type II secretion system protein	NA	NA	NA	NA
WP_089072018.1\|2423013_2423622_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_157724699.1\|2423569_2424067_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_089072019.1\|2424141_2424621_-	type II secretion system protein	NA	NA	NA	NA
WP_089072020.1\|2424655_2425210_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	A0A088F7U0	Vibrio_phage	2.7e-05	35.1
WP_089072021.1\|2425290_2425743_-	MSHA biogenesis protein MshF	NA	NA	NA	NA
WP_089072022.1\|2425742_2426969_-	type II secretion system F family protein	NA	NA	NA	NA
WP_089072023.1\|2426977_2428705_-	GspE/PulE family protein	NA	NA	NA	NA
WP_089072024.1\|2428694_2429864_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_089072025.1\|2429842_2430688_-	AAA family ATPase	J9SVV1	Pseudomonas_phage	2.6e-07	29.1
WP_089072026.1\|2430692_2432372_-	pilus (MSHA type) biogenesis protein MshL	NA	NA	NA	NA
WP_089072027.1\|2432386_2432704_-	MSHA biogenesis protein MshK	NA	NA	NA	NA
WP_089072028.1\|2432696_2433347_-	type 4a pilus biogenesis protein PilO	NA	NA	NA	NA
WP_089072029.1\|2433343_2434783_-	MSHA biogenesis protein MshI	NA	NA	NA	NA
WP_089072030.1\|2434795_2436817_-	RNase E specificity factor CsrD	NA	NA	NA	NA
WP_089072031.1\|2436936_2437179_+	hypothetical protein	NA	NA	NA	NA
WP_089072032.1\|2437473_2437734_+	hypothetical protein	NA	NA	NA	NA
WP_089072033.1\|2438244_2439744_+	hypothetical protein	NA	NA	NA	NA
WP_089072034.1\|2439774_2440380_+	hypothetical protein	NA	NA	NA	NA
WP_089072035.1\|2440444_2440765_+\|transposase	transposase	NA	NA	NA	NA
WP_089072036.1\|2440761_2441115_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	3.5e-14	46.7
WP_089072037.1\|2441174_2442704_+\|transposase	IS66 family transposase	S5VTP8	Leptospira_phage	7.7e-26	41.4
WP_089072038.1\|2442832_2443294_+	hypothetical protein	NA	NA	NA	NA
WP_089072039.1\|2443634_2445509_-	hypothetical protein	NA	NA	NA	NA
WP_089072040.1\|2445501_2449599_-	hypothetical protein	NA	NA	NA	NA
WP_089072041.1\|2449605_2450082_-	protein kinase	NA	NA	NA	NA
WP_089072042.1\|2450074_2452084_-\|integrase	integrase	NA	NA	NA	NA
WP_008486773.1\|2452076_2453660_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_089072043.1\|2453665_2454838_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
2466494:2466508	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022352

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP022353

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection