CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NZ_CP015279	Mycobacterium chimaera strain DSM 44623 plasmid unnamed 1, complete sequence	0 crisprs	c2c4_V-U1,csa3	1
NZ_CP015280	Mycobacterium chimaera strain DSM 44623 plasmid unnamed 2, complete sequence	0 crisprs	c2c9_V-U4,csa3	0
NZ_CP015278	Mycobacterium chimaera strain DSM 44623 chromosome, complete genome	5 crisprs	DEDDh,cas3,csa3,RT,DinG,cas4,WYL,c2c9_V-U4	8

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

431 : 64966

Mycobacterium_phage(60.0%)

protease,integrase,transposase

attL 3691:3706|attR 52775:52790

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047323915.1\|431_1484_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_047323904.1\|1498_2233_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_156181225.1\|2630_2807_+	hypothetical protein	NA	NA	NA	NA
WP_047323903.1\|2809_3019_-	hypothetical protein	NA	NA	NA	NA
WP_089150880.1\|3203_3830_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
3691:3706	attL	NA	NA	NA	NA
WP_074021058.1\|4185_5220_+\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	4.7e-11	23.8
WP_136246050.1\|5323_5959_+	hypothetical protein	NA	NA	NA	NA
WP_167384288.1\|5951_6296_+	hypothetical protein	NA	NA	NA	NA
WP_047323914.1\|6433_6946_+	hypothetical protein	NA	NA	NA	NA
WP_047323898.1\|7392_9345_+	hypothetical protein	NA	NA	NA	NA
WP_047323897.1\|9600_11157_+	ATP-binding protein	NA	NA	NA	NA
WP_047323896.1\|11344_11584_+	hypothetical protein	NA	NA	NA	NA
WP_047323895.1\|11810_12590_+	SseB family protein	NA	NA	NA	NA
WP_047323913.1\|12787_13324_-	hypothetical protein	NA	NA	NA	NA
WP_136246052.1\|13480_13660_+	hypothetical protein	NA	NA	NA	NA
WP_082147663.1\|13881_14319_+	hypothetical protein	NA	NA	NA	NA
WP_047323893.1\|14641_15463_+	hypothetical protein	NA	NA	NA	NA
WP_082147662.1\|15518_16139_-	hypothetical protein	NA	NA	NA	NA
WP_047323891.1\|16271_17300_+	hypothetical protein	NA	NA	NA	NA
WP_047323890.1\|17913_18252_-	hypothetical protein	NA	NA	NA	NA
WP_136246053.1\|18265_18928_-	hypothetical protein	NA	NA	NA	NA
WP_052955347.1\|19118_19361_-	hypothetical protein	NA	NA	NA	NA
WP_136246054.1\|19828_21685_-\|transposase	transposase	NA	NA	NA	NA
WP_047323886.1\|23661_24252_+	DNA-binding protein	NA	NA	NA	NA
WP_047323885.1\|25539_26508_+	ParA family protein	F0PIG8	Enterococcus_phage	1.1e-06	27.4
WP_047323911.1\|26504_27122_+	hypothetical protein	NA	NA	NA	NA
WP_047323884.1\|27129_29028_-	hypothetical protein	V5UNW4	Mycobacterium_phage	6.7e-112	39.2
WP_047323883.1\|29032_29746_-	hypothetical protein	NA	NA	NA	NA
WP_052955346.1\|30286_31189_+	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_052955345.1\|31325_32903_+	DUF4226 domain-containing protein	V5UPX1	Mycobacterium_phage	2.0e-08	42.7
WP_133058051.1\|32930_33236_+	hypothetical protein	NA	NA	NA	NA
WP_047323881.1\|33309_33615_+	ESX-1 secretion-associated protein	NA	NA	NA	NA
WP_047323880.1\|33630_35337_+	PE family protein	NA	NA	NA	NA
WP_047323879.1\|35333_35675_+	hypothetical protein	NA	NA	NA	NA
WP_047323878.1\|36003_36288_-	hypothetical protein	NA	NA	NA	NA
WP_052955344.1\|36298_36736_-	WhiB family transcriptional regulator	NA	NA	NA	NA
WP_158086686.1\|36925_37549_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_047323876.1\|37545_38607_+	hypothetical protein	A0A1P8D5M4	Corynebacterium_phage	1.3e-16	32.1
WP_047323907.1\|38870_39923_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_047324319.1\|39947_41165_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_136246450.1\|41389_42091_+	hypothetical protein	NA	NA	NA	NA
WP_047324298.1\|42105_42795_+	hypothetical protein	NA	NA	NA	NA
WP_167384289.1\|42800_42944_+	hypothetical protein	NA	NA	NA	NA
WP_142274731.1\|43029_43302_+	hypothetical protein	NA	NA	NA	NA
WP_139315450.1\|43971_46302_+	hypothetical protein	NA	NA	NA	NA
WP_047324166.1\|46821_47238_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_047324157.1\|47243_47507_-	type II toxin-antitoxin system VapB family antitoxin	NA	NA	NA	NA
WP_074021485.1\|47754_48588_+	hypothetical protein	NA	NA	NA	NA
WP_085081455.1\|49190_49808_+	transglycosylase SLT domain-containing protein	NA	NA	NA	NA
WP_139315451.1\|50016_50922_+	NlpC/P60 family protein	A0A1W6DXV0	Rhodococcus_phage	8.9e-14	39.1
WP_082147687.1\|50982_52524_+	type VII secretion protein EccB	V5UN45	Mycobacterium_phage	1.3e-60	34.5
WP_047324159.1\|52520_56732_+	type VII secretion protein EccCa	V5UPA0	Mycobacterium_phage	1.0e-112	27.3
52775:52790	attR	NA	NA	NA	NA
WP_047324169.1\|56828_57125_+	PE family protein	NA	NA	NA	NA
WP_047324160.1\|57149_58310_+	PPE family protein	V5UPR1	Mycobacterium_phage	4.3e-05	31.2
WP_047324161.1\|58451_58748_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_047324162.1\|58791_59076_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_047324163.1\|59157_60081_+	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_047324164.1\|60207_61716_+	MinD/ParA family protein	NA	NA	NA	NA
WP_082147688.1\|61712_63230_+	type VII secretion integral membrane protein EccD	NA	NA	NA	NA
WP_089150877.1\|63400_64966_+\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	5.0e-65	34.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP015278

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP015278_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP015278_1

406362-406450

Orphan

Consensus_repeat	Method
CCCTGGGGACCCGGCCCCGGCGG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP015278_1

>merge|NZ_CP015278|1|406362-406450|CRISPRCasFinder
CCCTGGGGGCCCGGCCCCGGCGGCCCCGGTTTGATCGTTCCGATGCCCCCGGGCGGCCCGGGCGGGCCCGGCGGTCCCGTCTCCGGCCC

>NZ_CP015278|1|1|406362-406450|CRISPRCasFinder
CCCTGGGGGCCCGGCCCCGGCGG	CCCCGGTTTGATCGTTCCGATGCCCCCGGGCGGCCCGGGCGGG
CCCGGCGGTCCCGTCTCCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP015278.1\|WP_072501477.1\|399669_401589_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP015278.1\|WP_042910512.1\|411721_412879_+\|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE	unknown	unknown	gnl\|CDD\|275139
NZ_CP015278.1\|WP_020821423.1\|407438_408740_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	unknown	unknown	gnl\|CDD\|274583
NZ_CP015278.1\|WP_042910513.1\|412875_413556_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP015278.1\|WP_042910516.1\|416733_417453_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP015278.1\|WP_042910502.1\|398660_399653_+\|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NZ_CP015278.1\|WP_042910515.1\|415174_416701_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_CP015278.1\|WP_014378919.1\|405432_405885_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368014
NZ_CP015278.1\|WP_042910505.1\|403140_404199_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_CP015278.1\|WP_008263260.1\|401874_403140_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_CP015278.1\|WP_042910500.1\|396620_397328_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_CP015278.1\|WP_161807779.1\|404336_405338_+\|DUF4185-domain-containing-protein	unknown	unknown	gnl\|CDD\|379383
NZ_CP015278.1\|WP_042910511.1\|410759_411725_+\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|226751
NZ_CP015278.1\|WP_042910510.1\|410049_410760_+\|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl\|CDD\|132483
NZ_CP015278.1\|WP_020821414.1\|396185_396608_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_042910508.1\|406602_407259_+\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|372884
NZ_CP015278.1\|WP_042910509.1\|408736_410050_+\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NZ_CP015278.1\|WP_008263246.1\|395567_396179_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP015278.1\|WP_042910514.1\|413566_415039_-\|glutamate--cysteine-ligase	unknown	unknown	unknown
NZ_CP015278.1\|WP_042910501.1\|397320_398550_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840

Protein	Function_ID	Function_description	E-value
NZ_CP015278.1\|WP_072501477.1\|399669_401589_-\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP015278.1\|WP_042910512.1\|411721_412879_+\|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE	gnl\|CDD\|275139	TIGR04343, pyridoxal-phosphate-dependent_transferase, ergothioneine biosynthesis PLP-dependent enzyme EgtE. Members of this protein family are the pyridoxal phosphate-dependent enzyme EgtE, which catalyzes the final step in the biosynthesis of ergothioneine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	7.90528e-170
NZ_CP015278.1\|WP_020821423.1\|407438_408740_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	gnl\|CDD\|274583	TIGR03444, EgtA_Cys_ligase, ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.99075e-164
NZ_CP015278.1\|WP_042910513.1\|412875_413556_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.24924e-19
NZ_CP015278.1\|WP_042910516.1\|416733_417453_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.02272e-23
NZ_CP015278.1\|WP_042910502.1\|398660_399653_+\|DEDDh-family-exonuclease	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	0
NZ_CP015278.1\|WP_042910515.1\|415174_416701_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP015278.1\|WP_014378919.1\|405432_405885_+\|hypothetical-protein	gnl\|CDD\|368014	pfam04592, SelP_N, Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyze redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharacterized.	1.38769e-05
NZ_CP015278.1\|WP_042910505.1\|403140_404199_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_CP015278.1\|WP_008263260.1\|401874_403140_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_CP015278.1\|WP_042910500.1\|396620_397328_-\|glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	9.4925e-115
NZ_CP015278.1\|WP_161807779.1\|404336_405338_+\|DUF4185-domain-containing-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	2.0628e-55
NZ_CP015278.1\|WP_042910510.1\|410049_410760_+\|ergothioneine-biosynthesis-protein-EgtC	gnl\|CDD\|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.45493e-109
NZ_CP015278.1\|WP_042910511.1\|410759_411725_+\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|226751	COG4301, COG4301, Uncharacterized conserved protein [Function unknown].	6.72733e-161
NZ_CP015278.1\|WP_042910508.1\|406602_407259_+\|sensor-domain-containing-protein	gnl\|CDD\|372884	pfam14032, PknH_C, PknH-like extracellular domain. This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	2.33066e-36
NZ_CP015278.1\|WP_042910509.1\|408736_410050_+\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	7.71579e-154
NZ_CP015278.1\|WP_008263246.1\|395567_396179_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	8.42319e-112
NZ_CP015278.1\|WP_042910501.1\|397320_398550_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	9.11159e-80

>NZ_CP015278.1|WP_014378919.1|405432_405885_+|hypothetical-protein
MSETPETPTVRTSTATAPAAAAAAYRAPRVFQLAAWVAIVAGIVFIVAVIFFTGFILGHRGGHHGHHHHKHHHHAMLHHRGPGGPGGPGGGTQGGPGAPTGPGATTAPASPSPVRPSGMAPGQLPASIFHSAAASHAAPGQAPSVIVLTN
>NZ_CP015278.1|WP_161807779.1|404336_405338_+|DUF4185-domain-containing-protein
MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPTELLQVCGDSFAGQGVGFGGWYAPVALHVDTASVDDPAGVRYTGVTGIAHPLLADPAPPDSSQLPAGVVQVNRRNYLMVTTTKDLEPQSSRLVTAEPARAGWQTIPGSKRPASYQGGSQTQISGYYDPIPTPESPSGWVYIVADSFTRRDPVVLYRATPQTFTDRSRWQGWAAGASGGWGKPPTPLWPDAVGEMCIRQIDGKAVLSYFNAATGNMEVRVAADPTALGDAPVTTVVQHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTLDELRIFVSQWDTRARVAAPYRVIQFAVNPFKPE
>NZ_CP015278.1|WP_042910505.1|403140_404199_+|aspartate-semialdehyde-dehydrogenase
MVAIGVVGATGQVGQVMRRLLDERDFPALNSGGSVRFFASARSQGRKLEFRGQEIEVEDAATADPSGLDIALFSAGKTMSLVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFTRDVANRARSLKKGIIANPNCTTMAAMPVLKVLHDEAGLQRLVVSSYQAVSGSGIAGVQELSTQARAVVDDAEQLVQDGGAVQFPAPKTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRHESRKILGIPDLAVSGTCVRVPVFTGHSLSINAEFARPLSPQRARELLDGAPGVKVVDVPTPLAAAGVDESLVGRIRQDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLAAEL
>NZ_CP015278.1|WP_008263260.1|401874_403140_+|aspartate-kinase
MALVVQKYGGSSVANADRIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLMDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAQARSFTGSQAGVITTGTHGNAKIIDVTPGRLQAALDEGRVVLVAGFQGVSQDTRDVTTLGRGGSDTTAVALAAALRADVCEIYTDVDGIFSADPRIVHNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRYNIPVHVRSSYSENPGTVVVGSIKDIAMEDPILTGVAHDRSEAKVTVVGIPDIPGYAARVFRALADADVNIDMVLQNVSKVEDGKTDITFTCSRDSGPTAVAKLDALKDEIGFSQLLYDDHVGKVSLIGAGMRSHPGVTATFCESLAEVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGGEESATVYAGTGR
>NZ_CP015278.1|WP_072501477.1|399669_401589_-|2-isopropylmalate-synthase
MTVTSNSDAFSSTRSIVKPAGPRGPGQPAWNPQRGSSMPVSRYRPFAEEVEPIRLADRTWPDRVITSAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITGGAIPDDVTIQVLTQCRPELIERTFEACLGAPQAIVHFYNSTSILQRRVVFRAEKAAVQDIATAGARKCVEEAAKYPGTRWRFEYSPESYTGTELEYAKQVCDAVGEIISPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKVDADAADTDVEDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKSDHGLALPRRLQIEFSQVVQKISEGEGGEVSPKEMWDAFSEEYLAPVWPLERVKQRVDASEEDSGVTSIAATVRINGVETEISGSGNGPLAAFVHALGDVGFDVAVLDYSEHAMSSGDDAQAAAYVEASVSIASAAEPGEAGLHPSGPVSIASAAEPGEAGRHPSGPVNGRTVWGVGIAPSITTASLRAVVSAVNRAARA
>NZ_CP015278.1|WP_042910502.1|398660_399653_+|DEDDh-family-exonuclease
MSAVCWGRPASEPDAGWAVIDVETSGFRPGQARIISLAVLGLDADGEVEQSVVSLLNPGVDPGPTHVHGLTAAMLEDQPQFADIASDVIDVLRGRTLVAHNVAFDYAFLAAEAELADIELPVDSVMCTVELARRLDLGVDNLRLETLAAHWSVTQERPHDAFDDAMVLTGVLASALKLARDGDVWLPVHPVTRRRWPNGRVTHDELRPLKVLASRMPCPYLNPGPYVGGRPLVQGMRVALAAEVGRTHEELVERILHAGLAYSEAVDRETSLVVCNDPAPEQGKGYLARKLGVPVISDATFMDCVRAVIGGTSMDEFTDTTNSDPQLALF
>NZ_CP015278.1|WP_042910501.1|397320_398550_-|Mur-ligase-family-protein
MVTTRARLALAAGASARWASRVTGRGAGAMIGGLIAMTLDRSVLRQLAAGRRTVVVTGTNGKSTTTRMTSAALATLGPVATNAEGANMDAGLVAALAANRRASLAALEVDEMHVPHVSDAVEPSVVVLLNLSRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVLMTSAAYDSPNVVWVAAGGSWSNDSVSCPRSGEVIVRERGHWFSTGADFKRPSPQWWFDDRTLHGPDGLSLPMRLTLPGAVNRGNAAQAVAAAVALGADPAKAVAAVSAVDEVAGRYRTVRVGDHEVRMLLAKNPAGWQEALSMVDKRAAGVVISVNGQVPDGEDLSWLWDVRFEHFEQTEVVAAGERGTDLAVRLGYAGVEHTLVHDTVAAIASCPPGRVEVVANYTAFLQLQRALARRG
>NZ_CP015278.1|WP_042910500.1|396620_397328_-|glutamine-amidotransferase
MADSTVRIGLVLPDVMGTYGDGGNALVLRQRLLLRGIPAEIVEITLADPVPESLDLYTLGGAEDYAQRLATRHLVKHPGLQRAAQRGAPVLAICAAVQVLGHWYETSAGQRVDGVGMLDATTSPQAARTIGELATRPLLAGLTERLTGFENHRGGTVLGPSASPLGAVVKGAGNRSGDGFDGVVQGSVIATYMHGPCLARNPQLADLLLGSVVGELPPLPMPEVDLLRRERLAAR
>NZ_CP015278.1|WP_020821414.1|396185_396608_-|hypothetical-protein
MMKIRPRLAAGAALVAAFVASSAPSHASPEVLNGRYNVLYADNDKPTAWLFVPCGSDCTLATSQDGGTFVISWEFHLADGRWTHSGTSQAPCPNGASAPVTVNYSFDAVSLAGEGQQTTTDACGPEAGRTFTRSFQLSKA
>NZ_CP015278.1|WP_008263246.1|395567_396179_+|recombination-protein-RecR
MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLAKVRDGVRFCAVCGNVSDNERCRICADPRRDGSQVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGVGPDQLRIRELLSRIGERVDDVDITEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMV
>NZ_CP015278.1|WP_042910508.1|406602_407259_+|sensor-domain-containing-protein
MTMRATHRAVLTVGFAVAGIVAPAVAAAHPSEPGVVNYAVLGKGSVGNIVGGPMGWESVFTQPGQGPWVDLPECNNWADIGLSEVYDDPDLASFNGAVTQTSANDQTHLVKQAVGVFATPDAAARAFHRVVDRTVGCSGQTTAIHLDNGSTQVWSFDGGPAGPADENWTKQEAGTDRRCFDQTRLRENVLLQAKVCQSGNAGPAVNVLAGAMQNALGQ
>NZ_CP015278.1|WP_020821423.1|407438_408740_+|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA
MTFAPITAAAPRSTGADPAPELKIAELTDSTAVAQYIADGCLVDAPLGRVGLELEAHCHDPAAPHRRPGWDEIAAVLDGLPALPGGSRITVEPGGAVELSGPPADGVLPAIEAMRRDQAVLQPAFAEAGLGLVFLGADPLRPPQRINPGARYRAMEKFFATSRSGEAGAAMMTSTASIQVNVDAGPREGWAARVRLAHALGPTMIAITANSPMLGGDFTGWVSSRQRVWGQMDSARCGPILGASGDDPGTDWGRYALKAPVMLVHTPGAEAVTQWVPFADWVDGRVLLGDRRPSVADLEYHLTTLFPPVRPRQWLEIRYLDSVPDALWPAVVFTLVALLDDPTAADAAAEAVAPVATAWDIAARLGLRDRRLYAAANACVAIAAERAPAELGDAMQRLVGLVEQGRCPGDDFADRVIEHGVAAEVSRAARGGL
>NZ_CP015278.1|WP_042910509.1|408736_410050_+|ergothioneine-biosynthesis-protein-EgtB
MTVTSCRETLADQLTRTRARTLRLVDFDDAELCRQYDPLMSPLVWDLAHIGQQEELWLLRGGDPGRPSMLSPAVEGLYDAFVHSRASRVDLPLLSPDEARAYCRTVRSAVFDALDALPDDPPGDEAAFAYAMVVSHENQHDETMLQALNLRSGPPLLCGTSMLPPARPGLAGTSVLVPGGEFVLGVDPATEPFSLDNERPGHVVDLPAFRIGRVPVTNGEWRHFIDDGGYDQPRWWSERGWRHRQAAGLTAPQFWNPDAATRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEMEWEKACAWDPSAGARRRYPWGAQEPCEALANLGGAALRPAPVGAYPAGASAYGAEQMLGDVWEWTSSPLRPWPGFVPMLYERYSQPFFDGDYRVLRGGSWAVEPGILRPSFRNWDHPYRRQIFSGVRLAWDVPKEIA
>NZ_CP015278.1|WP_042910510.1|410049_410760_+|ergothioneine-biosynthesis-protein-EgtC
MCRHLGWLGADVTVSSLVLDPPFGLRVQAYAPRRQKHCLLNADGWGVGFFDAASDGAAPRRWRSQLPLWGDVSFESVAPALRSHCVVAAVRSATVGMPIEVSATAPFTDGQWLLSHNGIVDRAVLPATSQAESVCDSAMLAAVIFERGLDALGDTIAEIAAADPRARLNILAANGSRMLATAWGDTLSILRRPDGVVLASEPYDNDSDWEDVPDRHLVEVTAGEVTMTPLDHPKGP
>NZ_CP015278.1|WP_042910511.1|410759_411725_+|L-histidine-N(alpha)-methyltransferase
MTLSLSNHLAADSAYHALRRDVFEGLQKTPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRAEAEILRARAAEIASASEADTLVELGSGTSEKTRLLLDALRTRGSLRRFVPFDVDASILSTAAAAIAQEYSGVEIKAVCGDFEEHLTEIPADGRRLFVFLGSTIGNLTPGPRADFLAALSAQMRPGDSLLLGTDLVKDLERLVRAYDDSAGVTAAFNRNVLAVVNRELDADFDVDAFAHVARWNPAEERIEMWLRADRGQRVRVGALELIVDFEAGEEMLTEVSCKFRPEKVSAELAAVGLRRTQWWTDGAGDFGLSLAVK
>NZ_CP015278.1|WP_042910512.1|411721_412879_+|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE
MTAGDSLADRWRAARPPMAGLHLDNAACSRQSVAVIDAAAQHARNESEVGGYVAAEAAAPVLDAGRVAFAALTGMTDAEVVFTTGSLHALDLLLGAWPTKHRTVACLPGEYGPNLAVMAAHGFDRRLLPTMDDGRVALDDAARALDTDRPDLVHLTAVASHSGVVQPVSMIAQLCRELGLPLVVDAAQALGQVDCAAGADATYSSSRKWIAGPRGVGMLAVRRELMESLRPRLAAPQWARASGSPTVAQQLEFGEANVAARVGFSLALGEHLAYGPAAVRARLAALGGLNRTVLADVAGWAVVEEVEEPSAITTLAPTDGADPQAVRDWLLAERRILTTFVGVQRAPLELPGPLLRISPHLDTTAEDLETFAEALIAATAATATG
>NZ_CP015278.1|WP_042910513.1|412875_413556_-|class-I-SAM-dependent-methyltransferase
MSSDQVMDWDSAYREQAHFEGPPPWNIGEPQPELAALVAAGKFRSDVLDAGCGVAELSLSLAAQGYTVVGVDLTPTAVAAATKSAQERGLTTASFVQADITSLSGYDGRFATVVDSTLFHSLPVEGRDGYLRSVHRAAAPGASYFVLVFAKGAFPSEMEPKPNEVDEDELRAAVSKYWEIDEIRPSFILSNAVNIADAPFEFPPHDRDEQGRIKMPAYLLTAHKTG
>NZ_CP015278.1|WP_042910514.1|413566_415039_-|glutamate--cysteine-ligase
MGEEVKRTTYDSAHRREYRRKVQSCLNVFETMLAQSCFDSDQPLTGMEIECNLVDADYQPAMSNRHVLDAIGDPAYQTELGAYNIEFNVPPHALPGHTGLDLEAEVRASLNEAEIKAGAADGAHIVMIGILPTLMPEHLDHDWMSESTRYAALNDSIFTARGEDLPIDIDGPEPLNWHAATIAPESACTSMQLHLQLAPETFAANWNAAQIVAGPQLALGANSPFFFSHQLWAETRIELFTQSTDTRPEELKTQGVRPRVWFGEQWITSVLDLYRENIRYFPSLLPEVSEEDPVAELAAGRTPQLSELRLHNGTVYRWNRPVYDVVDGRPHLRLENRVLPAGPTVVDMLANSSFFYGMLRSLSEADSPLWDHLDFAVAEANFLAAARHGIDARLHWPGLGEVSARDLVLDTLLPMADDGLRRWGVDPEVRDRFLGVIEGRARAGRNGATWQVSTVRALQDAGMGRAAALAEMLRRYCEYMHANEPVHTWE
>NZ_CP015278.1|WP_042910515.1|415174_416701_+|glycerol-kinase-GlpK
MAEFAEFVAAIDQGTTSTRCMIFDHEGAEVARHQLEHEQVLPQAGWVEHDPVEIWERTSSVLTSVLNRANLAPKNIAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALEGDGRGEVIRRKAGLPPATYFSGAKLQWILENVDGVRDAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFAIPRAMLPRIGPSSSPQPYGVTAETGPAGGEIAITGVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGETIVRSDNGLLTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSEALARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAGPADLRANWQEGRRWSPTWNDQQRAEGYAGWRKAVQRTLDWVSIT
>NZ_CP015278.1|WP_042910516.1|416733_417453_-|helix-turn-helix-transcriptional-regulator
MSNPFTPPEGPFGGRPGFGFGFGSGPVDRRALHEARRQARRDFREHLRDHAGGGHPGGYEGPFGFGPGFGPGFGPGFGFGPGGRRGAWRRGGPGRGKRGDVRAAILTLLSERPMHGYEMIQQIAERSNGLWKPSPGSVYPTLQLLDDEGLITASESAGSKKLFELTEQGRGAAEKIETPPWDEITEGADPGHMSLRAAVGQLFGAVGQSAHTASAEQQQRIVDILNNARREIYGILGED

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Crispr_ID: NZ_CP015278_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP015278_2

1713310-1713388

Orphan

Consensus_repeat	Method
TCCGCCGCGGAGGTCCGTGGGCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP015278_2

>merge|NZ_CP015278|2|1713310-1713388|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCCGCTGCGCCTCATCGCTTCGCATTGCATCGTCCGCCGCGGAGGTCCGTGGCCGCC

>NZ_CP015278|2|2|1713310-1713388|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCC	GCTGCGCCTCATCGCTTCGCATTGCATCG
TCCGCCGCGGAGGTCCGTGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP015278.1\|WP_020821961.1\|1720936_1721803_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_CP015278.1\|WP_008254722.1\|1701944_1702502_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP015278.1\|WP_020821956.1\|1714620_1715112_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NZ_CP015278.1\|WP_051197806.1\|1712399_1713308_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP015278.1\|WP_008254755.1\|1719075_1719465_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP015278.1\|WP_008254760.1\|1719988_1720867_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP015278.1\|WP_041320848.1\|1718572_1719058_+\|RrF2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
NZ_CP015278.1\|WP_042911042.1\|1704950_1707572_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NZ_CP015278.1\|WP_020821958.1\|1715743_1716673_+\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_CP015278.1\|WP_042911092.1\|1699996_1701763_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP015278.1\|WP_042911040.1\|1703135_1703639_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NZ_CP015278.1\|WP_042911043.1\|1707667_1708912_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP015278.1\|WP_008254752.1\|1716672_1718514_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
NZ_CP015278.1\|WP_009955270.1\|1713430_1714408_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP015278.1\|WP_042911041.1\|1703802_1704954_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NZ_CP015278.1\|WP_041320846.1\|1715190_1715631_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP015278.1\|WP_020821948.1\|1702510_1703041_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP015278.1\|WP_042911045.1\|1710567_1712403_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|182342
NZ_CP015278.1\|WP_051445846.1\|1708898_1710533_-\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP015278.1\|WP_020821960.1\|1719508_1719922_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898

Protein	Function_ID	Function_description	E-value
NZ_CP015278.1\|WP_020821961.1\|1720936_1721803_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.00297791
NZ_CP015278.1\|WP_008254722.1\|1701944_1702502_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	4.57725e-31
NZ_CP015278.1\|WP_020821956.1\|1714620_1715112_+\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.82269e-65
NZ_CP015278.1\|WP_051197806.1\|1712399_1713308_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.7458e-85
NZ_CP015278.1\|WP_008254755.1\|1719075_1719465_-\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	4.24427e-67
NZ_CP015278.1\|WP_008254760.1\|1719988_1720867_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.86964e-30
NZ_CP015278.1\|WP_041320848.1\|1718572_1719058_+\|RrF2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.50922e-49
NZ_CP015278.1\|WP_042911042.1\|1704950_1707572_+\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	7.45274e-09
NZ_CP015278.1\|WP_020821958.1\|1715743_1716673_+\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP015278.1\|WP_042911092.1\|1699996_1701763_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.70912e-159
NZ_CP015278.1\|WP_042911040.1\|1703135_1703639_-\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.15779e-45
NZ_CP015278.1\|WP_042911043.1\|1707667_1708912_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.0976e-11
NZ_CP015278.1\|WP_008254752.1\|1716672_1718514_+\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_CP015278.1\|WP_009955270.1\|1713430_1714408_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.50326e-99
NZ_CP015278.1\|WP_042911041.1\|1703802_1704954_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	6.12647e-63
NZ_CP015278.1\|WP_041320846.1\|1715190_1715631_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.31203e-31
NZ_CP015278.1\|WP_020821948.1\|1702510_1703041_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	3.73752e-31
NZ_CP015278.1\|WP_042911045.1\|1710567_1712403_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|182342	PRK10261, PRK10261, glutathione transporter ATP-binding protein; Provisional.	7.51722e-170
NZ_CP015278.1\|WP_051445846.1\|1708898_1710533_-\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.69623e-158
NZ_CP015278.1\|WP_020821960.1\|1719508_1719922_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	3.94653e-12

>NZ_CP015278.1|WP_051197806.1|1712399_1713308_-|ABC-transporter-permease
MDGAHGFSSHDAADFTSRRTLVLRRFARNRFAVASLTLLVLLFVGCYTLPAVLPFSYEDLDFTALLQPPSARHWLGTNALGQDLLAQILRGMQKSMLIGICVAVISTGIAATVGSVSGYFGGWRDRVLMWLVDLLLVVPSFILIAIVTPRTKDSANIVMLVLLLAGFGWMVSSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVASAILAETGLSFLGFGIQPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVLILVCANLTGDGLRDALDPGSTPVRGGAR
>NZ_CP015278.1|WP_042911045.1|1710567_1712403_-|ABC-transporter-ATP-binding-protein
MSPLLEVTDLAVTFATGGDPVTAVRGVSYRVEPGEVVAMVGESGSGKSVSAMAVVGLLPEYARVRGSVRLHDTELLGLDDDAMSRFRGKTVGMVFQDPMSALTPVYTVGDQIAEAIEIHQPRVGRRAARHRAVELLELVGIAQPERRARAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAEVHDLYRDRRMPYTVGLLGSVPRLDAAQGSRLVPIPGAPPSLAGLDPGCPFAPRCPLAIDECRLEEPELLPVGADHRAACIRTDQVGGRSAADIYGVSTTAVSARPDGSSVVVRVRDLTKTYRLTKGVLRRRAGEVRAVDGVSFELREGRTLGIVGESGSGKSTTLHEILELTGPQSGSIEVLGTDVTTLSSASRRSLRRDIQVVFQDPVASLDPRLPVFELLAEPLRANGFDKGRTNARVAELLEIVGLRRADAIRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQALFGLSYLFVSHDLSVIKHLAHEVVVMRSGTVVERGDSRQVFDNPQHEYTRQLLNAVPRPDPGARG
>NZ_CP015278.1|WP_051445846.1|1708898_1710533_-|ABC-transporter-family-substrate-binding-protein
MALALSGCSPAINLIPETGQNARIGTSSDINPRDPATLRDGGDLRLALTAFPPNFNILHIDGNSAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTGTAPQVVTYTINPKAVWSDGTPITWEDIASQVHALSGADKNFEIAGPSGAERVASVTRGVDDRQAVMTFAKPYAEWRGMFAGNGMLLPKSMTATPEAFNKGQLDGPGPSAGPFIATSLDRTTLRIVLSRNPKWWGPRPRLDNITYLVLDDAARLPALQNNTIDATGVGTIDQLTIAQRTKGITIRRAPAPAWSHITFNGAPGSILADKALRVAVSRGIDRQTIAKVVQYGLTSDPVALGNHIYVAGQKGYQDNSAVVPYDPAAAKRELDALGWKQVGQFREKDGRPLIIRDLFYDAQGSRQFAQIAQHSLAQIGVKLELVARAGSGFFTNYINVGAFDLAQFGWLGDAFPLSSLTQIYKSDGESNFGKIGSPQIDAAIERTLEELDPDRARALANELDRLIWAEGFSLPLTQSPGDVAVRSTLANFGAAGLGDLDYTAIGFTRS
>NZ_CP015278.1|WP_042911043.1|1707667_1708912_+|alpha/beta-fold-hydrolase
MTMNAKRSRVQQKLAELPGVRAVRRPISPHSADEFDLYYVRTGRKSRHPLVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRHDDSGADLPPQSMTVNQVVDDVAAVLDDAHADSADIYGASYGTYIAAGVGVRHPERVHAMVLDSPLLSRHDIVIVRRAIRRLLLRGDSPETAALAPKMRKLVDAGVMTPAATHVVATIYGYGGADLLERQLDLLLQRRKLLWWTLSRFTTLSNLPFRYEEDLVSRIAFRELDYAAEPDGLPLDPAVAESEARTHRVTFEDEPYDLPTEMPNFNWPTAVISGGRDLITPPAVAERVASLLPDAVLLSLPSMAHSALDFREPVALAAADAVGRGDLKGLAAQASALDALPPRPEVRLLWKLIETAAAAEGALPVPTRLLRRLSCA
>NZ_CP015278.1|WP_042911042.1|1704950_1707572_+|AAA-family-ATPase
MKLHRLILTNYRGISHREIEFPDHGVVVVCGANEIGKSSMIEALDLLLESRDRSTKKEVKQVKPTHSDVGSEVSAEISCGPYRFVYRKRFHKRCETELTIITPCREQLTGDEAHERVRAMLAETVDSDLWHAQRVLQSTSTAAVDLSGCDALSRALDVAAGDSGGLCGTEPLLIERIDTEYARYFTPTGRPTGQWAAAIARLADAEAAVAECAAAVAEVDDRVARHAVLTEQVADFSQRRIAAGPRVAAAREAADRIAELTAQQREAQLVAAAAAATSAAATAAHTGRLQLLAEIDARAGAVAETEAQAHQAACAHASARAEAEACDATLQRATQVLADLQCRVDAARRGVDRLADLEEVDRLSTRLAKVDAIERDRERICAELSTIAVTEELLRRIEDACAAVDRIGDHLASTSAAIEFTAAADIHLVVGGERISLSAGQSWSITAAGSTVVEVSDVLTARVTPGATTLDIHAKHAAAQQEMTAALAAAEVADLAAARSADQRRRELVSTRDQLGATLAGLCGDEQIDEMRSRLARLRAQHPAEPAPGATDIGAARAELDVAQQGHAAASTDCEAHRQAATAAAAALAELSTRATVLQNTLEAQRAELQAAAGRLAAERASVSDEELAASADSALRAEQAADQRVGELAAALAAASPDAVAAELAEATKEAESLRERYEEAARALREITIELSVFGSEGRQGKLDTAETEREHAATEHSQIGARARAAKLLRSVMTRHRDTTRRRYVEPYRAELQRLGRPVFGPSFEVDIDSDLCIRSRTLNGITVPYESLSGGAKEQLGILARLAGAALVAKEDAVPVVVDDALGFTDPDRLAKMGQLFDSVGTHGQVIVLTCSPDRYDGVRGAHRIDLTA
>NZ_CP015278.1|WP_042911041.1|1703802_1704954_+|exonuclease-SbcCD-subunit-D
MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLGALAAEVDAEFVVVSGDVFEHNQLPPTVIGQSLEAMRAIGIPVYLLPGNHDPLDASSVYTSALFAAERPDNVVVLDRAGVHQVRPGLEIVAAPWRSKVPTTDLVADVLDGLPAAAGIRILVAHGGVDVLDPDKDKPSLIRLATLDDALSRGAVHYVALGDKHSLTQVGDSGRVWYSGSPEVTNFDDVESDPGHVLVVDVDETDPRGAVSVTARDVGRWRFVTLHRQVDTSRDIADLDVNLDLMTDKDRTVVRLALTGSLTVTDRAALDACLDKYARLFAWLGLWERHTDLAVIPADGEFSDLGIGGFAAAAVEELVATAREEDSATAVDAQAALALLLRLADRGAA
>NZ_CP015278.1|WP_042911040.1|1703135_1703639_-|histidine-phosphatase-family-protein
MTAERTLLLMRHAKSDYPAGVADHDRPLAPRGVRQAGLAGDWLRAHVPPVDRVLCSTATRTRETLRNTRIDAPVRYSERLYASTPGTLIDEINTVDDGIGTLLVIGHEPTMSALALGLGRAGGTDDAAAERISAKFPTSAIAVLAVPCAWKELELGGASLIDFVVPR
>NZ_CP015278.1|WP_020821948.1|1702510_1703041_+|DUF3558-domain-containing-protein
MRAAAVLLLAALLVLTGCSRSIGGNAVKAGGNVPRNNNSQQQYPNLLKECEVLTSDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGSLSNERKVAEFLKYKIESRPIAGIDSIVMRPDDANGACGVASDAAGVVGWWVNPQAPGIDACGQAIKLMELTLATNS
>NZ_CP015278.1|WP_008254722.1|1701944_1702502_+|DUF3558-domain-containing-protein
MRRSARALALVASALTILIPAVAACSDSGGNKPGATASSTPQKGQGNHGPMFPQCGGISDQTVAELTRVTGLINTARNSVGCQWLAGGGILGPHFSFSWYRGSPIGRERKTEELSRASVDDININGHGGFIAVGNEPNLGDSLCEVGIQFQDDFIEWSISFSQKPFPPPCDIAKELARQSIANSK
>NZ_CP015278.1|WP_042911092.1|1699996_1701763_-|ABC-transporter-ATP-binding-protein
MLLALLRQYIQPYRRLVAVLMVLQLISNLASLYLPTVNAAIIDEGVAKGDTAAIVRLGIVMLGATGLQVLCSVGAVYFGSRTGMGFGRDLRAAVFEHVLTFSERESARFGAPTLLTRSTNDVRQIQYLVQITATVLVTAPIMCLGGIVMALRQEAALTWLLLVSVPVMAVTNYWVMSHMLPLFRRMQGLIDGINRVMRDQLAGVRVVRAFAREGFERDRFARANAALSNTALTAGNWQALMLPVTTLTINVSSVALIWFGGLRIDRGQMQVGSLTAFLAYFTQILMAVLMATMTLVVLPRASVCAERITEVLTTRPAVTDPPGPASPPGKITGVVRLDGATFTYPGADRPVLQDISFIARPGTTTAIVGSTGSGKSTLISLICRLYDVTGGTVLVDDIDVRDYHTERLWSAIGLVPQRGYLFSGTIADNLRYGAAPGHDITGDEMWEALRVADADGFVRAHPDGLQMRVAQGGINFSGGQRQRLAIARAVIRRPAVYLFDDSFGALDVHTGARVRAALKPISKEATVIVVTQRVSTAAQADQVIVVDGGRLVGAGTHESLLADSATYAEFADSQAVGALPSGHVGGAQ
>NZ_CP015278.1|WP_009955270.1|1713430_1714408_-|ABC-transporter-permease
MTRFLARRLLNYVVLLALASFLTFCLTSVAFKPLDSLLQRNPRPPQAVIDAKAHALGLDEAIPIRYAHWASHAVRGDFGKTVTGQPVGESLWRRVGVTLRLLVIGSLVGTVAGIAAGAWGAIRQYRLSDRVVTMVALLVLSTPTFVIANLLILAALRVNWAVGLQIFDYTGETSPGVSGGAGAHFFDRLRHLVLPSLTLALAAAAGYSRYQRNAMLDVLGQDFIRTARAKGLTRRRALVKHGLRTALIPLATLFAYGVAGLVTGAVFVEKIFGWHGMGEWLVQGIATQDTNIVAAITVFSGAVVLLAGLLSDVFYAALDPRVRVS
>NZ_CP015278.1|WP_020821956.1|1714620_1715112_+|carbonic-anhydrase
MTVTDDLLANNAEYAKTFNGPLPMPPGKHVAVVACMDARLDVYRLLGLNEGEAHVIRNAGGVVTDDVIRSLAISQRLLGTREIILIHHTDCGMLTFTDDDFKRSIQEETGVKPPWAAEAFPDVAEDVRQSLRRIEGSPFVTKHVSARGFFFDVATGKLNEVTL
>NZ_CP015278.1|WP_041320846.1|1715190_1715631_-|PaaI-family-thioesterase
MTSHSGPSRPPAPSGRDVIAQFLPQSPFVVKLGIVADRLEEDEVRLRLPWDPSNVTIGDMVHGGAIATLADLTVMAAAWCGVPAPPELRGVTVSMALDYMAPARATDVIGIGRVLRRGRSLVNCEAEIVDSGGTLVAKALATYKVG
>NZ_CP015278.1|WP_020821958.1|1715743_1716673_+|sulfate-adenylyltransferase-subunit-CysD
MTSDLKTAPAVGQYELSHLRSLEAEAIHIIREVAAEFERPVLLFSGGKDSIVMLHLALRAFRPGRLPFPVMHVDTGHNFDEVIATRDELVKEHGVRLVVASVQEDIDAGRVVEPRQGRNPIQTVTLLRAIRENKFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAENIALPSIYYAHRRKVFRRDGMLLAVDKNMQPNADEPVFEATVRFRTVGDVTCTGCVESQAATVEEVIAETAVSRLTERGATRADDRISEAGMEDRKRQGYF
>NZ_CP015278.1|WP_008254752.1|1716672_1718514_+|adenylyl-sulfate-kinase
MATLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDKEKFEAIRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNMVDVRFPVQYVIRPHTREHQDHRSYAGTVASGVMRAGDEVVVLPVGKHTRITAIEGPNGPVEEAFPPMAVSVTLADEIDISRGDLIARTHNQPRVAQEFDATVCWMADGAALEPGRDYVIKHTTRTTHAKVTALDYRLDVNTLHRDKSATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKPSAIAQARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGSLAYVLDGDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFEFIEVFCDTPIDECEKRDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLTPDGTIEEQAQRVLDLLESRG
>NZ_CP015278.1|WP_041320848.1|1718572_1719058_+|RrF2-family-transcriptional-regulator
MRMSAKAEYAVRAMIQLATVPDGTLVKTDDLAQAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARSGSDISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRSVLEQTTLADVATGGLPKHVAQLADDYRKQESQRHGSARTGD
>NZ_CP015278.1|WP_008254755.1|1719075_1719465_-|VOC-family-protein
MSISFNHTIVASRDKRESAEFLTELFGLPSPKPFGHFMVVELEHGATLDYADAPDGADIPRQHYAFLVSEQEFDTIYDKIRARGMQHWADPGATRPGEINHNDGGRGVYFTDPSGHAMEILTRPYGSGG
>NZ_CP015278.1|WP_020821960.1|1719508_1719922_-|VOC-family-protein
MDFTSTSIAHVRLTVTDIERSRQFYESVFGWPVLLEVPDNADEATRNQLSFLFGGVIYDLGGTLLGLRPVAAGRFDENRVGLDHIAFRLTTRDELDSAAAHLDELGVAHEPIKDIGPSYILEFRDPDNIALELTAPK
>NZ_CP015278.1|WP_008254760.1|1719988_1720867_+|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDATVLETWARTIDEGPFSSLCWGERIAFDNPDNLTLLGALAAWTDRVRLLTTVIVPQLHDPVMLAKGLATGDMLSGGRLTVGIGVGGRHEDYHAVGADPATQTMRGMAERVAVMKRVWAGEKTTDSVRPVGPAPVQPGGPPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQNELFDVTRDAWARAGKPKPHLITSFWFAFGSPEESRAQVHRHLRRYMNWIPAEYVDAMAPMTGWAGSEDELLDVLRRFEEIGTDEVQLIPTSSDVDQLRRAAEVAGRL
>NZ_CP015278.1|WP_020821961.1|1720936_1721803_+|tetratricopeptide-repeat-protein
MTQQELPAPLAEMTGLMARCANNGDFAGAALQANELVTLCRATLGERDPNVLELKVALATVQLRAGEDADVYADLDALIPDLVAVLGPDHLSTLTARHLFAGRQQPPVSSLSEWSQLVADEQRILGPDHESTLMARERVAEKRWETGDFAGAMTEGQHVLAARRRVLGDDHADTLGTRLMLAIWRGRAGDIPGAITELEWLIGELRDKLGSGHVHLLMARHMFTLWAPKRAGVTDGVTAWEALVEEEARVLGDEHPVTIAARQELAGWCARHRARAGEPDTPVDWSAS

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Crispr_ID: NZ_CP015278_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP015278_3

2641619-2641732

Orphan

Consensus_repeat	Method
GGTGTGATCGCGGCTTCGCCGCTCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP015278_3

>merge|NZ_CP015278|3|2641619-2641732|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACA

>NZ_CP015278|3|3|2641619-2641732|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACA	TGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCG
GGTGTGATCGCGGCTTCGCCGCTCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP015278.1\|WP_008256210.1\|2645024_2645294_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_008256203.1\|2642002_2643358_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163
NZ_CP015278.1\|WP_161807821.1\|2643927_2644992_-\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NZ_CP015278.1\|WP_085976493.1\|2649120_2649888_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|224139
NZ_CP015278.1\|WP_014384578.1\|2645290_2646313_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP015278.1\|WP_014384579.1\|2646467_2646770_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_054585469.1\|2637381_2638158_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402
NZ_CP015278.1\|WP_008256146.1\|2635409_2636567_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NZ_CP015278.1\|WP_008256205.1\|2643394_2643925_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|224793
NZ_CP015278.1\|WP_054585458.1\|2632714_2634196_+\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_CP015278.1\|WP_008256225.1\|2648256_2649045_+\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NZ_CP015278.1\|WP_003878110.1\|2639034_2639325_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP015278.1\|WP_054585463.1\|2640821_2641496_-\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|224837
NZ_CP015278.1\|WP_054585465.1\|2646844_2647597_+\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NZ_CP015278.1\|WP_054585462.1\|2640479_2640818_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|376764
NZ_CP015278.1\|WP_054585461.1\|2638224_2638869_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|224712
NZ_CP015278.1\|WP_008256222.1\|2647658_2648246_+\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|213872
NZ_CP015278.1\|WP_008256153.1\|2639588_2640386_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226127
NZ_CP015278.1\|WP_054585459.1\|2634192_2635143_+\|cell-division-protein-FtsQ/DivIB	unknown	unknown	gnl\|CDD\|224505
NZ_CP015278.1\|WP_072501282.1\|2636629_2637376_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|224413

Protein	Function_ID	Function_description	E-value
NZ_CP015278.1\|WP_008256203.1\|2642002_2643358_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0
NZ_CP015278.1\|WP_161807821.1\|2643927_2644992_-\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NZ_CP015278.1\|WP_085976493.1\|2649120_2649888_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|224139	COG1218, CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism].	1.26252e-75
NZ_CP015278.1\|WP_014384578.1\|2645290_2646313_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00934122
NZ_CP015278.1\|WP_054585469.1\|2637381_2638158_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	3.06984e-80
NZ_CP015278.1\|WP_008256146.1\|2635409_2636567_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NZ_CP015278.1\|WP_008256205.1\|2643394_2643925_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|224793	COG1881, COG1881, Phospholipid-binding protein [General function prediction only].	5.12793e-60
NZ_CP015278.1\|WP_054585458.1\|2632714_2634196_+\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_CP015278.1\|WP_008256225.1\|2648256_2649045_+\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	2.09061e-125
NZ_CP015278.1\|WP_003878110.1\|2639034_2639325_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	1.05966e-07
NZ_CP015278.1\|WP_054585463.1\|2640821_2641496_-\|phosphoribosyltransferase	gnl\|CDD\|224837	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only].	7.58023e-93
NZ_CP015278.1\|WP_054585465.1\|2646844_2647597_+\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	9.41418e-122
NZ_CP015278.1\|WP_054585462.1\|2640479_2640818_+\|phage-holin-family-protein	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	0.00355035
NZ_CP015278.1\|WP_054585461.1\|2638224_2638869_+\|cell-division-protein-SepF	gnl\|CDD\|224712	COG1799, COG1799, Uncharacterized protein conserved in bacteria [Function unknown].	3.81459e-45
NZ_CP015278.1\|WP_008256222.1\|2647658_2648246_+\|DUF3090-domain-containing-protein	gnl\|CDD\|213872	TIGR03847, TIGR03847, conserved hypothetical protein. The conserved hypothetical protein described here occurs as part of the trio of uncharacterized proteins common in the Actinobacteria.	2.70755e-88
NZ_CP015278.1\|WP_008256153.1\|2639588_2640386_+\|DivIVA-domain-containing-protein	gnl\|CDD\|226127	COG3599, DivIVA, Cell division initiation protein [Cell division and chromosome partitioning].	5.87672e-33
NZ_CP015278.1\|WP_054585459.1\|2634192_2635143_+\|cell-division-protein-FtsQ/DivIB	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	1.98809e-51
NZ_CP015278.1\|WP_072501282.1\|2636629_2637376_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|224413	COG1496, yfiH, Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism].	6.6978e-96

>NZ_CP015278.1|WP_054585463.1|2640821_2641496_-|phosphoribosyltransferase
MNRPNGFLRRTATRNFRDRREAGRALAEELTSYRGRDLLVFGLARGGVPVAWEIAAALGAPLDVFLVRKLGVPNWSELAMGALASGGGLVMNDDVVASLRVTDEQVREVIDSETTELLRREHAYRGDRPIADPRDRVVILADDGIATGASMLAAVRAVRAAGPESITVAVPVGPESACRDLAREADDVVCATMPPGFEAVGQVYDDFHQVSDDEVRELLATPTA
>NZ_CP015278.1|WP_054585462.1|2640479_2640818_+|phage-holin-family-protein
MLVIALVLALIGLVALVFAVVTSNELVAWLCIAASVVGVVLLILDALRERQHREPGGAEDQDADEARPDEDDYVDYPEEAAAEGEAEAVADGTEPTAESSVAAEGRGDESAK
>NZ_CP015278.1|WP_008256153.1|2639588_2640386_+|DivIVA-domain-containing-protein
MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVEAELTRLIEENSDLRQRIEELDQELASGGGAAAPAAAAAPTQAIPVREPEPEPVKAAAAPAAAVNNEEQAMKAARVLSLAQDTADRLTSTAQAESEKMLSDARANADQILSEARSTAETTVAEARQRADAMLADAQTRSETQLRQAQEKADALQADAERKHSEIMGTINQQRTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSADAGGFDQFNRGNN
>NZ_CP015278.1|WP_003878110.1|2639034_2639325_+|YggT-family-protein
MVLFFQILGFALFIFWLLLIARVVVEFIRSFSRDWHPTGITVVVLEIIMSITDPPVKLLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAA
>NZ_CP015278.1|WP_054585461.1|2638224_2638869_+|cell-division-protein-SepF
MSTLHKVKAYFGMAPMDDYEDEYYDDRAPSRGFPRPRFDDGYGRYDGDDYDDPRREPADYPPPGGYRGGYAEEPRYGSVHPREFDRGERGGPRFGSWLRNSTRGALAMDPRRMAMMFEEGHPLSKITTLRPKDYSEARTIGERFRDGTPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
>NZ_CP015278.1|WP_054585469.1|2637381_2638158_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MAVEISNGGDRESELTHALAAVRSRLAAAAEAAGRNVAEIEVLPITKFFPATDVVTLSRLGCRAVGESRDQEATAKVAEVTRLLAAPERADVGNPRWHMVGHIQRNKARSVAGWAHTAHSVDSAHLVTALDRGVAAALAEGRRTDPMRIYVQVSLDGDESRGGVDISRPGAVDQMCDQVEGSTNLALAGLMAIPPLDSDPDEAFDRLQSEHRRVLESHRNAVGLSAGMSNDFEIAVKHGSTCVRVGTALLGRRRLPSP
>NZ_CP015278.1|WP_072501282.1|2636629_2637376_+|peptidoglycan-editing-factor-PgeF
MQPGGQRLPDTGHVSVRIRRVTTTRAGGVSKPPFDTFNLGDHVGDDPAAVAENRSRLAAGIGLRAGRMVWMNQVHGDRVEVVDGPREAAVDDTDALVTRTARLALAVVTADCVPVLMADARAGVAAAVHAGRVGAQRGVVARTVEAMLELGARPHDISALLGPAVSGLNYEVPAAMADEVEAALPGSRTTTGAGTPGLDLRAGIACQLQGLGVTAIDIDPRCTVGDPTLFSHRRDAPTGRLASLVWME
>NZ_CP015278.1|WP_008256146.1|2635409_2636567_+|cell-division-protein-FtsZ
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRRAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRGNQAESGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHQDANIIFGTVIDDSLGDEVRVTVIAAGFDATGPGRKPVIGGNADKEEKVGAHRIESAKAGKLTSTLFEPVDAVSVPVHTNGSTLNIGGDDDDVDVPPFMRR
>NZ_CP015278.1|WP_054585459.1|2634192_2635143_+|cell-division-protein-FtsQ/DivIB
MTQPPPEPTVGDQADNPVPDDAATEPLVTGAGDQAAADQTPDPAEVEGPRRRARRERAERRAAQARATAIEEARREAKRRATGRPVHEPKPVARGVVRGLKMLLVTILLVIVGVGLALVLYFTPAMSARNIVVIGTGAVTREEVLDAARVRPGTPLLQINTSQVADRVAAIRRVASARVQRQYPSALRITIVERVPVAVKDFPDGPHLFDRDGVDFATGPPPPALPYLDVADPGPNDPATKAALQVLTALRPEVSDQVGRVAAPSVASITLTLGDGRVVIWGTTDRTDEKAEKLSALLTQPGKVYDVSSPDLPTVK
>NZ_CP015278.1|WP_054585458.1|2632714_2634196_+|UDP-N-acetylmuramate--L-alanine-ligase
MTTEQLPPELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGIHALRARGAQITIGHDAASLDLLPGGATAVITTHAAIPKTNPELVEARRRGIPVILRPAVLAKLMNGRTTLMVTGTHGKTTTTSMLIVALQHCGRDPSFAVGGEMGEAGTNAHHGSGDCFVAEADESDGSLLEYTPNVAVVTNIETDHLDFYGSADAYVGVFDSFVDRLAPGGALVVCVDDPGAAALARRTAELGIRVLRYGSGASLSGEPLAATLLSWQQQGTEAVAQIQLAPDLDPEQHPRVMRLSVPGRHMALNAMGALLAALEIGAPADAVLDGLAGFEGVRRRFELVGTAGNGQPVRVFDDYAHHPTEIVATLAAVRTLLEQSGDGRSIAVFQPHLYSRTKAFAEEFGHALDAADEVFVLDVYGAREQPLAGVSGASVAEHVSVPVRYLPNFSAAAEQVAAVAGPGDVIVTMGAGDVTLLGPEIVTALRVRANRGAPGALR
>NZ_CP015278.1|WP_008256203.1|2642002_2643358_+|M20/M25/M40-family-metallo-hydrolase
MTIQSGATEEPTNPSDDVVEVVSKLIRFDTTNTGEPETTKGEAECAQWVAEQLAEVGYAPQYVESGAPGRGNVFVRLPGADPSRGGLLIHGHLDVVPAEPTEWSVHPFSGAVKDGFVWGRGAIDMKDMVGMMIVVARQLKRAGIVPPRDLVFAFIADEEHGGTFGAQWLVDNRPDLFDGVTEAIGEVGGFSLTVPRRDGGERRLYLIETAEKGLSWMRLTARGPAGHGSMVHDQNAVTAVAEAVARLGRHQFPLVLTDTVAQFLAAVSEETGLTFDTESGDLRGAVEKLGPMARMLKAVLHDTANPTMLKAGYKANVVPAIAEAVVDCRILPGRKEAFEAEIDELLGPDVTREWIKDFSSYQTSFDGDLVDAMNAAVLALDPDARTVPYMLSGGTDAKSFARLGIRCFGFSPLRLPPDLDFTALFHGVDERVPIDALRFGTDVLTHFLTHC
>NZ_CP015278.1|WP_008256205.1|2643394_2643925_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSTAPDPYASLPKLPTFTLTSQSVTDGQPLAKPQVSGIMGAGGEDVSPQLSWSGFPDGTRSFAVTVYDPDAPTASGFWHWAVANLPADVTELAEGAGDGSNLPGDALTLVNDAGLRRYLGAAPPAGHGPHRYYIAVHAVDTDKLDLPEDASPAFLGFNLFQHAIARAVIHATYEQK
>NZ_CP015278.1|WP_161807821.1|2643927_2644992_-|quinone-dependent-dihydroorotate-dehydrogenase
MYGLLRQLFFVIPPERIHTLVFGFLRGVTAVAWARRALRRLLGPTDPALASTVFGVRFPGPLGLAAGFDKDGLGVLTWGALGFGHAEVGTVTAHPQPGNPAPRMFRLPADRALLNRMGFNNLGAGALAMRLARQRPEVPIGVNIGKTKATPADQAVDDYRASARLVGPLASYLVVNVSSPNTPGLRDLQAVDSLRPILSAVLAETTTPVLVKIAPDLSDADVDAIADLAVELGLAGIVATNTTISRQGLRTPGVDELGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIENADDAWERITAGASLLQGYTGFIYGGGLWAKQIHDGVARRLHDGGFASLSEAVGAAARG
>NZ_CP015278.1|WP_008256210.1|2645024_2645294_-|hypothetical-protein
MTAARHSRLPAGWDTEMSDEYEWVPLRLPPEVTRVSASTRLSIEAEYRGWELTRVRLYNDGSRRVLLRRKKSRLDGTGYEGRRPDQPQL
>NZ_CP015278.1|WP_014384578.1|2645290_2646313_-|hypothetical-protein
MLSLAVLLGATVGCSSNPLAGAPRTIEPAAAAVSPPPSQSPAGAVRPLPAHAAAAVFDAGTRRLAVLAPGSDPAAPGSITVFGEAQAPPRVVDLPGPASALTDDGQGTAYLAARGGYFAVDLSTGHTAQVSVSDAAQTEFTAVARRADGRLVLGSADGAVYTLASPKPGAVSAASVASRNKVFARVDCLVTQGDTTVVLDRGQTSVTTIDADGHVQQALRAGRGATTMAADALGRVLVADTRGGQLLVYGVDPLILRQAYPVSQAPYGLAGSRALAWVSQTVSNIVIGYDLSTGIPVEKVRYPTVQQPNSLAFDEASDTLYVVSGSGAGVQVIDHAAGRR
>NZ_CP015278.1|WP_014384579.1|2646467_2646770_+|hypothetical-protein
MAVTADRHMTQEEFAVEDMSTGIFASGYGQVGDGRSFSFHIENRSLVVEVYRPRLAGPVPQADEVVATAVRSLVDIDLTDERSLSAAVRDSVAHAEPVSR
>NZ_CP015278.1|WP_054585465.1|2646844_2647597_+|MSMEG_4193-family-putative-phosphomutase
MTVILLRHGRSSSNTAGILAGRSEGVDLDDKGREQAAALIDRIGDLPIRELITSPLLRCRRTLEPLADALCLAPLVEDRLAEVDYGEWTGRKIGELVSEPLWKVVQAHPSAAVFPGGEGLAQVQARAVAAVREHDRRLASEHGGDALWVACTHGDVIKAVIADAYGIHLDGFQRVTADPASVSVIRYTELRPFVLHVNHTGARLSAALRAGPQPKEEATAETDGQPNGEAQAPPAAGVPSSDAVVGGSTD
>NZ_CP015278.1|WP_008256222.1|2647658_2648246_+|DUF3090-domain-containing-protein
MSRAIHVFRTPDRFVAGTVGQPGNRTFYIQAVHDARVVSVILEKQQVAVLAERIGALLLEVNRRFGTPVPPEPAEVEDLKPLITPVDAEFRVGTMGLGWDSEAQTVVVELLAVTDAEFDASVVLDDTEEGPDAVRVFLTPESARQFASRSNRVISAGRPPCPLCDEPLDPEGHICARANGYRRNALLGSDDDPEV
>NZ_CP015278.1|WP_008256225.1|2648256_2649045_+|SCO1664-family-protein
MLRNGELTVIGRIRSASNATFLCESTLDERAVHCVYKPVAGEAPLWDFPDGTLAGRERAAYLVSAQLGWNIVPYTIIRHGPAGPGMLQQWVQQPGDTVDTEPRPGPDLVDLFPAGKAQPGYLPVLRAYDYAGDEVVLMHADDIRLWRMAVFDVLVNNADRKGGHVLRDLDGHIFGVDHGVCLHVEDKLRTVLWGWAGKPIDSQTCKAVAGLAEALTGSFGDELAEHITSAEIAALRMRAHALLDNPVMPGPNRHRPIPWPAF
>NZ_CP015278.1|WP_085976493.1|2649120_2649888_+|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MTDAALAADLAAEAGELLLKVRDEVGFGYPWALGDAGDSLANDLILRRLRVERPGDAVLSEEAYDDLSRLQHDRVWIIDPLDGTREFSTPGRDDWAVHIALWQRPSDGQREITDAAVSLPARGNIVYRSDTVTAGAARAGVTDTIRIAVSATRPPAVLHRMRQTLPIQPVAIGSAGAKAMAIIDGDVDAYVHAGGQWEWDSAAPAGVVMAAGMHASRLDGSPMRYNQLDPYLPDFVMCRAELAPILLGAIRDAWR

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Crispr_ID: NZ_CP015278_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP015278_4

4117916-4118012

Orphan

Consensus_repeat	Method
TGCCCGGCGTCGGCTGTGGCTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP015278_4

>merge|NZ_CP015278|4|4117916-4118012|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGGTGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCCTGCCCGGCGTCGGCTGCGGCTCCGG

>NZ_CP015278|4|4|4117916-4118012|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGG	TGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCC
TGCCCGGCGTCGGCTGCGGCTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP015278.1\|WP_036453354.1\|4112911_4113712_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP015278.1\|WP_051445912.1\|4111520_4112255_-\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|274008
NZ_CP015278.1\|WP_042912581.1\|4127859_4128867_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239607
NZ_CP015278.1\|WP_042912571.1\|4115629_4116829_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP015278.1\|WP_042912575.1\|4121268_4122795_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341286
NZ_CP015278.1\|WP_008258632.1\|4123664_4124126_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP015278.1\|WP_042912576.1\|4125415_4126774_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_CP015278.1\|WP_042912568.1\|4113754_4114504_+\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|366780
NZ_CP015278.1\|WP_042913030.1\|4108422_4109325_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NZ_CP015278.1\|WP_008258621.1\|4112354_4112840_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP015278.1\|WP_042913034.1\|4122864_4123674_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_CP015278.1\|WP_008258652.1\|4128988_4129639_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|132427
NZ_CP015278.1\|WP_042912569.1\|4114520_4115633_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP015278.1\|WP_009952956.1\|4124118_4124577_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_042912578.1\|4126780_4127863_-\|dihydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|226326
NZ_CP015278.1\|WP_042913037.1\|4124573_4125311_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_CP015278.1\|WP_008258618.1\|4109454_4110207_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|234847
NZ_CP015278.1\|WP_042913032.1\|4116825_4117608_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NZ_CP015278.1\|WP_042912573.1\|4118035_4121272_-\|carbamoyl-phosphate-synthetase	unknown	unknown	gnl\|CDD\|237263
NZ_CP015278.1\|WP_042912564.1\|4110256_4111468_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755

Protein	Function_ID	Function_description	E-value
NZ_CP015278.1\|WP_036453354.1\|4112911_4113712_-\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP015278.1\|WP_051445912.1\|4111520_4112255_-\|cell-division-protein-DivIVA	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	2.28412e-05
NZ_CP015278.1\|WP_042912581.1\|4127859_4128867_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239607	cd03531, Rieske_RO_Alpha_KSH, The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway, catalyzing the 9 alpha-hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD). KSH is a two-component class IA monooxygenase, with terminal oxygenase (KshA) and oxygenase reductase (KshB) components. KSH activity has been found in many actino- and proteo- bacterial genera including Rhodococcus, Nocardia, Arthrobacter, Mycobacterium, and Burkholderia.	7.16801e-30
NZ_CP015278.1\|WP_042912571.1\|4115629_4116829_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.80373e-131
NZ_CP015278.1\|WP_042912575.1\|4121268_4122795_-\|AMP-binding-protein	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	1.68965e-133
NZ_CP015278.1\|WP_008258632.1\|4123664_4124126_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.40179e-12
NZ_CP015278.1\|WP_042912576.1\|4125415_4126774_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.2479e-79
NZ_CP015278.1\|WP_042912568.1\|4113754_4114504_+\|dienelactone-hydrolase	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	3.47996e-60
NZ_CP015278.1\|WP_042913030.1\|4108422_4109325_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	7.08269e-146
NZ_CP015278.1\|WP_008258621.1\|4112354_4112840_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	5.01316e-61
NZ_CP015278.1\|WP_042913034.1\|4122864_4123674_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	9.53006e-22
NZ_CP015278.1\|WP_008258652.1\|4128988_4129639_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	0.000338941
NZ_CP015278.1\|WP_042912569.1\|4114520_4115633_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.57619e-42
NZ_CP015278.1\|WP_042912578.1\|4126780_4127863_-\|dihydrodipicolinate-reductase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.66987e-38
NZ_CP015278.1\|WP_042913037.1\|4124573_4125311_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	4.13355e-99
NZ_CP015278.1\|WP_008258618.1\|4109454_4110207_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|234847	PRK00847, thyX, FAD-dependent thymidylate synthase; Reviewed.	3.54e-100
NZ_CP015278.1\|WP_042913032.1\|4116825_4117608_-\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	1.12702e-124
NZ_CP015278.1\|WP_042912573.1\|4118035_4121272_-\|carbamoyl-phosphate-synthetase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	5.77895e-168
NZ_CP015278.1\|WP_042912564.1\|4110256_4111468_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.37232e-105

>NZ_CP015278.1|WP_042913032.1|4116825_4117608_-|SDR-family-oxidoreductase
MTSQDLTGRTAIITGASRGIGLSIAQQLAAAGANVVLTARKQEAADEAAAQVGERAVGVGAHAVDEDAARRCVDMTLERFGTLDILVNNAGTNPAYGPLIDQDHARFTKIFDVNLWAPLLWTSLAVKSWMGEHGGSIVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPRVRVNAICPGVVRTRLAEALWKDHEDPLASSIALGRIGEPIDVAAAVAFLVSDAASWITGETMVIDGGLLLGAAQGFRPAPGGGQ
>NZ_CP015278.1|WP_042912571.1|4115629_4116829_-|acyl-CoA-dehydrogenase
MNAVDTAELDARVQALLDEHDPNESDAREFLGAQYDAGLAWVHLPRGFGGLDLPRTAQDRVDARLAAAGAPVGGTPKNYIGMGMAAPTIAAFGTDEQKRKFLRPLFTGEQIYCQLFSEPGGGSDLAGVSTRAVRDPHNPEDWIVNGQKVWTSQAQHAHMAILVARTDPAVPKHAGLTYFLCDMTQPGVEIRPLRQITGEAEFNEVFLTDVRVPDANRLGPEGGGWRVATTTLNNERVAIGSRAGAPREGGHIGKVADAWRAEPALRDPAMHDQLMRLWVEAEVFRLAGERLRQQAATGQPGPEGAGMKVAFAKLAQAISGFEIELHGESGLYYDDWTLRRPETVDLVGRGPGYRYLRARGNSIEGGTSEILRNTISERILGLPGEHRVDKDAAWKDLPR
>NZ_CP015278.1|WP_042912569.1|4114520_4115633_-|acyl-CoA/acyl-ACP-dehydrogenase
MSSLRAATGDLLYSDTEEALRAGVRQLFAERCPPESVAGVYDAQPQDFSGVWRTLATELGVAGLLVPESLGGAGASAREAAVVMEEIGRAVAPVPFLSSAVLATVALLRAGDTRTVSGLAQGELTAALVVPLTTAPGDPVTGVSGGPGGLSGSVTAVAGAGEADVLVVPVTGPDGLELHTVDRAAAGVQVSPLLALDMTRPLAAVTFSGAPSSKVGAGDGPVADAVRTGAALLASEQLGVAQWCFDTTLDYAGQRRQFGRTIGSYQAIKHRLADLWFDVGAAAAAARYAADTCARADDDAAAAAAIAQAYCSDIAVHAAEECIQLHGGIGMTWEYPAHLYLKRAKSDQLAFGTGYRHRARLAELVNLPPT
>NZ_CP015278.1|WP_042912568.1|4113754_4114504_+|dienelactone-hydrolase
MPNITDVVTTPDGTCPVHLFTPDGPESQVPWPGVVMYPDAGGVRGTFEEMAARLAGFGYAVLLPDVYYRTADWAPFDMATVFNDQSERGRLFSMIGSVTPDRMAADATAFFDYLAARPEVSGERFGVCGYCMGGRTSLIVAGRVPDRVAAAASFHGGGLVTDTDDSPHLLADRMSATVYVGGAQNDASFTADHAEQLDKALTAAGVEHTIEWYSAGHGFAVPDNAPYDPAAAERHWDAMTDVFAAAFPR
>NZ_CP015278.1|WP_036453354.1|4112911_4113712_-|thymidylate-synthase
MPIPTPYEDLLRLVLDEGTAKSDRTGTGTRSLFGRQLRYDLSAGFPLLTTKKVHLKSVVYELLWFLRGDSNVGWLREHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPNSRRIIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQSGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLGERDSIFDYTYDDVVVRNYDPHPAIKAPVAV
>NZ_CP015278.1|WP_008258621.1|4112354_4112840_-|dihydrofolate-reductase
MGLVWAQSTSGVIGRGGGIPWNVPEDLARFKEVTIGHTVVMGRRTWDSLPAKVRPLPGRRNVVLSREDGFAADGAQVVGSLDAAFARAEGEPAVWVIGGGQVYLAALPYATRCEVTEIELDLRRDDDDALAPALDDTWVGETGEWQASRSGLRYRFHSYRR
>NZ_CP015278.1|WP_051445912.1|4111520_4112255_-|cell-division-protein-DivIVA
MITEPVKTFSRKFMGYDASAVDAHIEMLTTKQQLLLDDVESLRARLQESGEQTAALRKEVAALTDTSPSSHAMQKRMAKMLQRAVDEVAEMQAEARAEADALIAAAEAEAEAAERKRDEVLADMAAQQKALEAEYEQTKEKLDAELAEMRAETQAAIDEARRNAERECERLLGDAKQGADHYRDKARRAVDEATAQRIEILEQLMGVYRDLDGVPAALEAAYQEQKNPSEDGALAPVDGKVRAS
>NZ_CP015278.1|WP_042912564.1|4110256_4111468_-|winged-helix-turn-helix-domain-containing-protein
MSTRRLSAAQARRIAVAAQGFTEPRPGGQITRVHLKRLISRIQVLQLDSVSVAVRAHYAPVFSRLGPYDRDVLDRAAWGLRSSRLLAEYWAHEAALMAVEDWPLLRWRMRQYRHGRWGTHIVKANPRLAEKVVAAVAELGPSTAGQIEAHLAAGPRGPRGSWWGSRSDTKWVAEALFSAGVLTTATRVGFARHYDLVERVLPAAVLAREVDDDEALRELTLRAATALGVGTEADIRDYFRLSAAQVKPAIAQLLAAGDIERVDVDGWSGPAYLRAGRTVPRVDRGTALLCPFDPLIFFRPRVERLFEFHYRIEIYTPAAKRQYGYYVWPLLMDGRLVARVDLKADRPADTLRVVGTFAEPDAPKARVAAALAGELRSMASWLGLGGFSVSGRGDLAADLRAIS
>NZ_CP015278.1|WP_008258618.1|4109454_4110207_-|FAD-dependent-thymidylate-synthase
MAEIAPLRVQLIAKTEFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHLSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPETDSHVVVPPGMEDDPELRQILAAAADASRATYTELLAKLEAKFADQPNAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAGAAPAVFADFEISALADGTEVATSPLATEA
>NZ_CP015278.1|WP_042913030.1|4108422_4109325_-|4-hydroxy-tetrahydrodipicolinate-synthase
MSTAGFDAPARLGTVLTAMVTPFRPDGSLDTATAAHLANHLIDAGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGSYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQSGLIAHFTTVADATALPVVLYDIPPRSVIPIQPETIRALAAHPNIVGIKDAKADLHSGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLREMLSAFNSGDIATARKINSTVAPLCDAMARLGGVTLSKAGLRLQGIDVGDPRLPQMPATPEQIDALAVDMRAASVLR
>NZ_CP015278.1|WP_042912573.1|4118035_4121272_-|carbamoyl-phosphate-synthetase
MSASLLVANRGEIALRIIRTATELGMRTIAVYADDDAQSPHVHAADEAIVLPGSGPRAYLDQSAMLAVAKRTGADLIHPGYGFLSENAEFADACVAGGVTFVGPDPGVLGLLGNKTAARGAALAAGVPVLPATDGASSVEEVAAFFAAQRGGIMLKALAGGGGRGMRKVHRADQIDDAYQRCAAEAQLGFGDPALYAEALLDDARHIEVQVVAAPAGHQTHALAVGDRDCSIQRRYQKLVEIAPAQGLSDELRRALHQAAVRLCARVGLRGLATVEFLVTGEDFVFLEANPRIQVEHTVTEEITGLDLVAVQLAIAGGTSFYGLGLPAGIASDGLEVIGEPAAQRGIAIQLRVNAETFGPDLSVLPSAGTLTAFTPPSGPGVRVDTYGRPGLAVSPQYDSLLAKVIVHVRGTSWPAALRKADTALSEFGIEGIHTNIGFLRELLRAERVESGWVSTGFVDEKLPELARATQSHQQEPPPASVELYPGEEALRAQLAGTVVEVAPEGVEHAAGSQLVVLEAMKMQHVLVAPDALRTVRTLVTPGQVVGTGDPLLIFTRTESGNDGESARAATDLDRPRADLDEVTRRHALTLDEGRAAAVAKRHQQGRRTARENIADLVDPGSFVEYGALAIAAQRSRRSEEDLIANTPADGLVAGLATIGAQRFGRAAAQAVVVSYDYTVLAGTQGMRNHAKTDRAFDLAARKRLPVVLFAEGGGGRPGDTDVGGAAGLDVPTFRMLAGLRGEVPLVSIVSGRCFAGNAALAGVCDVIIATPDANIGMGGPAMIEGGGLGVYPPEAIGPIGVQRRNGVVGLVARDEAHAVALAKQYLSYFQGSLGEWEEPDPRLARHVVPQNRLRAYDVHRAIEAIVDVGSVLELRPDYGVGIVTALVRVEGVPYGLIANSTHHLGGAIDAEAADKTGDFLALCESFGLPVISLCDTPGFMVGPDAETQAAVRRFGRMFVLGARLTVPLGMIILRKAYGLGAMAMAGGSFRAPQFTIAWPTGEIGGMGLEGAVRLGYSKELAAAEESGDPAERQSLFDRLVAAAYEHGKALRAATTFELDDVIDPSASRAWITRLSGG
>NZ_CP015278.1|WP_042912575.1|4121268_4122795_-|AMP-binding-protein
MIEIARDHNPFPTVGVSRGRDGVPRYDELPATLLDMLAEHVDTRPGSEAVVELGGGRLTYRQLWDRSARVAGGLRAEGIKRGDRVAVRYPAGIDWVLAFWGVVMAGGIAVAVNTRSAQPEVDFVLSDSGAGLDLAPDSPLPDGPPYVSEHLGRADVAALFYTSGTTGHPKGVPTTHEAFLTNTENSLRCSGFARDVGERLRTLISVPLFHVTGCNTQLLVAMRLGGTSVIMPTLNLDELITVLTTERISLMVTVPAVYALLLRHKAFAGTDVSGVRWVGYGGAPIAPSLVRAVQNAFPQATVFNGYGMTETASLATVLPHHDAVEHADSVGYAVPSVDLGVIPFDEDEPGVGELVVRGANVTGGYWNRPEANAATFTDGWLHTGDVVRVDDAGRVHLIDRLKDIINRGGENVSSVEVEAVLLAAPHVADACVLGVPDDVMGEKVGAVLFGGDDDIDVPAVLEHCRGRLADFKVPQYVTVVDTALPRNAGGKLLKARLREQVRWGDPLR
>NZ_CP015278.1|WP_042913034.1|4122864_4123674_+|thioesterase-family-protein
MPEAFFTVDGDSYVPGAMTQGPWGAAMGGQIVGGLLGWGIEQSGVDADLQPARFTVDLLRPALMSPVQIRTSVLREGRRIKLVDGELVQNGTVVARASALFLRRGDHPDGRVWSFPVEMPPLPTSSDGFPEAMPFLIWGYGATRDGSPGIAAGEWEQSDSQKFAWARIFRPMVQGHPLTPFTRLAFAGDITSSLTHWGTGGLRYINADYTVTASRLPDGEFLGLAAQSHYGTAGVATGAATLFDRHGPLGTSSALALAQPADAFKPTYA
>NZ_CP015278.1|WP_008258632.1|4123664_4124126_-|flavodoxin-family-protein
MSKTLLIVHHTPSPHTHEMFEAVVSGATDPEIEGVEVLRRPALTVSPAEMLAADGYLLGTPANLGYISGALKHAFDCSYYQLLDSTRGRPFGLYLHGNEGTEGAERAVDTITTGLGWSKAAETVVVSGKPGKEQLQACWELGATVAAQLMDYA
>NZ_CP015278.1|WP_009952956.1|4124118_4124577_-|hypothetical-protein
MTKALRTQLLVAFMCVALLVYFALLGRVAVAMIASGRAAAVGLGLAVLVMPVIGLWAMVATLRAGFAHQRLARLIAADGMELDTSDLPRRPSGRIQRDAADALFATVRTEVEDHPDDWRRWYRLARAYDYAGDRRRAREAMKTAVNLQGDHE
>NZ_CP015278.1|WP_042913037.1|4124573_4125311_-|4-hydroxy-tetrahydrodipicolinate-reductase
MRVGVLGAKGKVGSTMVAAVQAAEDLTLSAEVDAGDPLSLLTDGGTEAVIDFTHPDVVMGNLEFLIGNGIHAVVGTTGFTAERLQQVRAWLAESPKTSVLIAPNFAIGAVLSMHFARQAAPFFDSAEVIELHHPHKADAPSGTATRTAKLIAESRKGLPPNPDATSTSLPGARGADVDGIPVHSVRLAGLVAHQEILFGTEGETLSIRHDSLDRTSFVPGVLLAVRRITEHPGLTVGLEPLLNLQ
>NZ_CP015278.1|WP_042912576.1|4125415_4126774_+|HNH-endonuclease
MHSIEVPPEVSAALDALDAAAAAIRGLNFDQLDPAVRLRALERMEASRRRQIAVSHDVIAGLAREDPAALGGPVHKVIADWLRIGCGEASRRLHDATRLSPRLTLTGQELPPELPATAVAWRDGLLDGQHLRVIQSFVRDLPASTPVAKVETAERFLANEAAKLRPDQLQKLAHRYALSINPDGKFSDADRARQRGFTWCGQSPDGMSVGKLVASPELRANLDAWMSHFAAPGMCNPDDETPCVAGEPDDERVRRDLRSHAQRQHDALNALVRGQLGDPKLGQHNGLPVAVIVATTLRELTSGTGRAVTGGGTLLPMRDVIRMGRHAYHYLAVFDEHSSRPLYLGRSRRIASPDQRVVLYAQDRGCTHPGCDAPGYWCEAHHLKEWAAGGATDADNLTFACGPHHRLVEKGWRTRKNARGDTEWIPPPRLDRGVRTNDYHHPERGIGDRAGP
>NZ_CP015278.1|WP_042912578.1|4126780_4127863_-|dihydrodipicolinate-reductase
MSTAPIRVFQVGSGNVGSEMIRRIATQPDLELIGVHAYSPEKVGTDTGEFAGLGTNGVKFTGTIEEIIAAKPDVLTFHGVFPDEDLYLHVLEAGIDIVTTADWITGWHRDTNHPHPSGKPVSKLLAEACEKGGATFYGTGMNPGLNQILGVVCSADVADIENITTIESVDVSCHHSKDTWIEVGYGQPVDDPDIPSKLEKYTRVFADSVYMMADCFDLTLDEVTFSYELGACTKDVDLGWYTLPKGSLGGNYIRYQGMVDGVPRVETHLEWQMTPHTDPSWNIKGCYITQIKGDPCIYNKHMIFPKPGVDLSNPDSFASIGMTVTGMPALAAIKSVIAAPPGLITSADLPLRGFAGRFKK
>NZ_CP015278.1|WP_042912581.1|4127859_4128867_-|Rieske-2Fe-2S-domain-containing-protein
MAKPPLSMKPTGWFQVAWSDEIGVGDVHKIKYFDSEMVAWRAESGQLTVMNAYCEHLGAHLGYGGTVVGEVLQCPFHGWQWSADGRNVCIPYQDRPNRGRRMRTYPVVERNASVYIWHDVERREPYFEPPDVFAAFDDGSSADDYYPQQRLYRETLEMHPQYVLENGVDFAHFKFVHKTPIVPVFTRHDFAEPVSYVDFTITFEGDDGQKIEDVNSGVQAINGGLGIAVTKSWGMIDNRTISAITPVDERTSDVRFMVYIGRAPGGDSERAERKAAEFGQEVIRQFTQDIEIWQHQRYSDPPALAPDEYEGFTAIRQWAKQFYPEAFVSQEGLAQ
>NZ_CP015278.1|WP_008258652.1|4128988_4129639_+|TetR/AcrR-family-transcriptional-regulator
MTRQTSGAGIAGRRPNRRGHATRESMLEAALRSLASGEPGSVSANRIAKDIGATWGAVQYQFGDTDGFWAAVLHRTAERRAATFSTLSAPISPDAPLRERVGAIIDTLYTGLASADSRAIENLRAALPRDPDELERLYPRTAAELFSWGKSWLETCQQAFAGLAVDPDRVREVAALIPGAMRGLVSERQLGSYADLDMARRGLTNALAAYLEPSRP

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Crispr_ID: NZ_CP015278_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP015278_5

4667189-4667322

Orphan

Consensus_repeat	Method
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP015278_5

>merge|NZ_CP015278|5|4667189-4667322|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTACCCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGGGGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

>NZ_CP015278|5|5|4667189-4667322|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGG
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP015278.1\|WP_161807806.1\|4664967_4667079_-\|ATP-dependent-DNA-helicase-UvrD2	unknown	unknown	gnl\|CDD\|223288
NZ_CP015278.1\|WP_008259653.1\|4668531_4669602_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|367001
NZ_CP015278.1\|WP_042913117.1\|4678485_4679673_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NZ_CP015278.1\|WP_054585280.1\|4672994_4676120_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP015278.1\|WP_162494288.1\|4664705_4664867_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_042913116.1\|4676489_4677275_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP015278.1\|WP_139315468.1\|4658430_4658784_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_042913111.1\|4664311_4664563_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP015278.1\|WP_054585282.1\|4669650_4672998_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP015278.1\|WP_008259631.1\|4662958_4664302_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_CP015278.1\|WP_074021601.1\|4657989_4658376_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_139315466.1\|4660197_4660491_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_074021613.1\|4661080_4662550_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NZ_CP015278.1\|WP_080691230.1\|4676207_4676444_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_008259667.1\|4677595_4678450_-\|TIGR02569-family-protein	unknown	unknown	gnl\|CDD\|131620
NZ_CP015278.1\|WP_014712227.1\|4667599_4668532_-\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699
NZ_CP015278.1\|WP_042913114.1\|4667333_4667588_+\|mycoredoxin-Mrx1	unknown	unknown	gnl\|CDD\|131255
NZ_CP015278.1\|WP_074021611.1\|4660487_4660715_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235235
NZ_CP015278.1\|WP_139315467.1\|4658836_4660201_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP015278.1\|WP_014712233.1\|4677277_4677589_+\|DNA-methyltransferase	unknown	unknown	gnl\|CDD\|226219

Protein	Function_ID	Function_description	E-value
NZ_CP015278.1\|WP_161807806.1\|4664967_4667079_-\|ATP-dependent-DNA-helicase-UvrD2	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	5.60173e-121
NZ_CP015278.1\|WP_008259653.1\|4668531_4669602_-\|potassium-channel-family-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	9.10223e-24
NZ_CP015278.1\|WP_074021611.1\|4660487_4660715_-\|hypothetical-protein	gnl\|CDD\|235235	PRK04165, PRK04165, acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional.	0.00325705
NZ_CP015278.1\|WP_042913116.1\|4676489_4677275_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.28646e-16
NZ_CP015278.1\|WP_042913117.1\|4678485_4679673_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NZ_CP015278.1\|WP_042913111.1\|4664311_4664563_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	2.08659e-14
NZ_CP015278.1\|WP_054585282.1\|4669650_4672998_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.82567e-108
NZ_CP015278.1\|WP_008259631.1\|4662958_4664302_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	3.1123e-124
NZ_CP015278.1\|WP_074021613.1\|4661080_4662550_-\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	7.95512e-24
NZ_CP015278.1\|WP_008259667.1\|4677595_4678450_-\|TIGR02569-family-protein	gnl\|CDD\|131620	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein. This protein family is found, so far, only in Actinobacteria, including as least five species of Mycobacterium, three of Corynebacterium, and Nocardia farcinica, always in a single copy per genome. The function is unknown. [Hypothetical proteins, Conserved].	4.73137e-135
NZ_CP015278.1\|WP_014712227.1\|4667599_4668532_-\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	1.62433e-124
NZ_CP015278.1\|WP_054585280.1\|4672994_4676120_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	9.21813e-72
NZ_CP015278.1\|WP_042913114.1\|4667333_4667588_+\|mycoredoxin-Mrx1	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	4.87391e-42
NZ_CP015278.1\|WP_014712233.1\|4677277_4677589_+\|DNA-methyltransferase	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.81839e-30

>NZ_CP015278.1|WP_161807806.1|4664967_4667079_-|ATP-dependent-DNA-helicase-UvrD2
MPTVADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAAGQVLAVTFTQRAAGEMRSRLRAIDAAAGMGPAVGAVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRARLNASTDEVRDLAGEIEWAKASLIGPEEYPTAVAAAGRDIPLDAAQIAGVYAAYEALKARGEHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDVTPLQQRVLTAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVAGSKLHLVGQRPPGPAPMFHEHPDEPAEAAAVAASIGRLIESGTPPSEIAVLYRVNAQSEIYEEALTEAGIAYQVRGGEGFFNRQEIKQALLALHRASERATARGAEGPLPDVVRAVLEPLGLTAQEPVGTRARERWEALSALAELVDDEVAQRPQLDFPGLLAELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGAESEAVEEERRLLYVGITRARTHLALSWALARSPGGRQGRKPSRFLNGIAPQARAEAGPNKSRRNRATATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLLRLKAWRLDVAKEQKVPAYVVFTDNTLIAIAELRPDDDEALIAIPGIGARKLEQYGPDVLELVRGR
>NZ_CP015278.1|WP_162494288.1|4664705_4664867_-|hypothetical-protein
MLSDAFGAGVARAELSAGTSHAAHAAVSAAARKHRAAAATDASVGVGGPPKAT
>NZ_CP015278.1|WP_042913111.1|4664311_4664563_-|WhiB-family-transcriptional-regulator
MSAPTAPRPHLPCHAGDPDLWFAEAPADLERAKSLCVDCPVRRQCLAAALERAEPWGVWGGEIFDRGSVLSFKRPRGRPRKAA
>NZ_CP015278.1|WP_008259631.1|4662958_4664302_+|AarF/ABC1/UbiB-kinase-family-protein
MDDGYVADIKRGRAARNAKLASIPVGFAGRAALGFGKRLTGKSRDEVQAELLEKAAHQLFTVLGELKGGAMKVGQALSVLEAAIPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTMQRLVGVFKQLAPGADIQGVVDELIERTEMELDYRLEAENQRAFAKAYHDHPHFAVPRIVASAPKVVIQEWMQGIPMAEIIRHGTTEQRDLVGTRLLELTFDAPRRLEMLHGDAHPGNFMLLDDGRMGVIDFGAVAPLPGGLPIELGMSIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMDLPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAVV
>NZ_CP015278.1|WP_074021613.1|4661080_4662550_-|recombinase-family-protein
MAERAALYARISLDRTGEEVGVNRQLHDMRLLAEARGYEIVAELVDNDMSASKGLRRPGYEQVWQLVTAEKVDHVVVWQSSRLMRSRNDRAAVIETFGRHRVDVVAVKGPSLDLRSAYGRGAADLMTAIDSMEGEIKAERVAAAIGDLARRGQAWGLCPYGWDRINGEQVINDHEAAIVRELVDRLLAGESLNELYRDMNARGEPAPGWATWMKLPAARREQLLAKGRKEPTKQWAKSTVRTLVVRDANAGIRRYRKRVNGGTEMPGGWQPIVERAQHDRVVALLAQPDRRSHTGPRPGARKHLLTNGIGKCGVCGDMLRVGNRARSQGRIYMCRGRGCTGRVQAHVDEVVAVAVIGRLQMPDALDWLLGDDEQAHRLQKRCDELQGRLDAAADSQADGKITIGQLERITARLMPELEAAKRERDAAAKALDVELLRELAGPQGSQRWDAMPVSARRAVLETLKVEVVLMPRKKHGPGFEPETVDVVFR
>NZ_CP015278.1|WP_074021611.1|4660487_4660715_-|hypothetical-protein
MPKIPTEPAARSQFFRDIALKSAEARRANRDARISEQRTERLAAHIAKSLEKAPPLSDEQRQRIAELLRPAVKSA
>NZ_CP015278.1|WP_139315466.1|4660197_4660491_-|hypothetical-protein
MSAKKSHMPSSRDDDDQKPDRAAVRAARLCGILAAASVLLAACASGAADTAQPAESRSGSSASEWFGRILRNLTSPPAPPSVDPLSAIACVDQGGSE
>NZ_CP015278.1|WP_139315467.1|4658836_4660201_-|hypothetical-protein
MSAIATATAATTAPTADRKVGNQAKFAFIYEAGADPEISDAAYRVASLTALKKAGSKGFFKATRKEMAKLCAISLRKVDRAVSELARMNYWDVESSTGGANTIRLITPAERKELWDDAKRQWLDDEDRRIFAEKQAERERLEAEKAAHDEFIKTVNDAIREHVPSLRFDRPVKLDRGAVDQTIEAWWNIHQEHGIRADMFVRIVQSWTADDIPTLPKDDPQPTAGDTFWGSAAASDPDPDPVSRPSAGNRETDQIWQGGSTPVARGLHTDGKGGPHQWQGGSTPVAIPLATPDPLTSANGHSHKSLKDPERPLKALKDLESSLGAPRALERALCAGSEGQPQPQPADVGQSKAGLECGLCGPAGLLMDRDGFRVTMENDAGVVRFIPCRHSMASNIEFIKTLDGVDGFGLSRSCWVELDRAFGIEPEDYEHIETVHLGSGEIVHYAFDPEYIDG
>NZ_CP015278.1|WP_139315468.1|4658430_4658784_-|hypothetical-protein
MSEIYELPFVRNGIDSPARQRRFALSQEQRLIGDMTAVVLTDETGTESWHLVAPDWLANLKRGGSLQFELPVHEREGYIGDDWQRKVYEVIGWPTADERHRMRAVQRRRLRRISREP
>NZ_CP015278.1|WP_074021601.1|4657989_4658376_-|hypothetical-protein
MTTVWHAPDPFAPWHIHQRGTCKICGFNPDAAPTLKGKLNMSEPNQKRDDALLTALALLEQHDAARENPLLAQTLLGGLDAESCVRLIASLASLAHHLAGEVAELTGAPVEDILAQLRHIHTEHLGAA
>NZ_CP015278.1|WP_042913114.1|4667333_4667588_+|mycoredoxin-Mrx1
MTTAPLTVYTTSWCGYCHRLMTVLKSNGIPYEAVDIEHDAAAADFVSSVNGGNRTVPTVKFADGSTLTNPSAAQVKAKLTETGS
>NZ_CP015278.1|WP_014712227.1|4667599_4668532_-|NAD(+)-diphosphatase
MAIADFQLRSVPLLSRVGADRADQLRTDVEAATAGWADAALLRVDSRNQVLVSDGRVVLGAAAELGDKPPSEAVFLGRLEGGRHVWAIRGALQAPEDPDARTEVVNLRSLGPIFDDTSGQLMSSAVALLNWHEKSRFSSVDGSPTRPARAGWSRVNPVTGHEEFPRIDPAVICLVHDGGDRAVLARQAVWPERMFSLLAGFVEAGESFEGCVAREIREEIGLTVRDVRYLGSQPWPFPRSLMVGFHAVGDPAQDFSFNDGEIAEAAWFTRDEVREALAAGDWSSSSESKLLLPGSISIARVIIESWAAID
>NZ_CP015278.1|WP_008259653.1|4668531_4669602_-|potassium-channel-family-protein
MGNGRSRKLSGLDETLTAQRGHQLIGVVRIPEEHASPIRVITRRLAIALVVLFGAAVIVYLDRDGFRDVRNEPLTFLDCLYFSAVSLSTTGYGDITPYTETARLVHTLIFTALRIAFLAVLVGTTLEVLSERSRQGWKIQRWRSRVRNHTIVIGYGTKGKTAVAAILGDETIQAEVVVVDTDRSTLEHAESAGLVTVHGDATKADVLRLAGAQHAASIIVATSRDDTAVLATLTAREIAPNAKIVASIREAENQHLLQQSGADSVVVSSATAGRLLGLATTTPSVVEMIEDLLTPDAGLAIAEREVEQSEVGGSPRHLRDIVLGVVRDGHLWRIDAPEVDAVEANDRLLYIRSVGH
>NZ_CP015278.1|WP_054585282.1|4669650_4672998_-|ATP-dependent-helicase
MNARYNPSELACALGLFPPTEEQSAVIAAPPGPLVVIAGAGAGKTETMAARVVWLIANGYAEPAQVLGLTFTRKAAGQLLRRVRSRLARLAGVGLGPVGDAAAEPEGAPVISTYHAFAGSLLRDYGLLLPVEPDTRLLSETELWQLAFDVVNGYRGELHTDKTPAAVTSMVLRLWGQLAEHLVDTGQLRDTHVELERLVHGLPAGPYQRERGPSQWLLRLLGTQTERAELVPLLDALDERMRAEKVMDFGMQMASAARLAAGFPQVGADLRARYRVVLLDEYQDTGHAQRIALSALFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPRSDGTPAPVLELRTSWRNPPQTLRVANAVSAEARRRSVAVHALRPRPDAPPGTVRCALLPDVVAEREWIADHLDAHYRRARAEGVSPPTAAVLVRRNADAAPIADALRARGIPVEVVGLAGLLSVPEVAEVVAMLRLVADPTAGAAAMRVLTGARWRLGARDIAALWQRARALGGTAADPAPPSPEAIARAADPSHVDADTVCLADAIADPGPAGAYSAAGYQRITALGAELSALRAHLGHPLADLVAEVRRVLGVDCEVRAAAGVAAGWAGTEHLDAFADVVAGYAERADGAATRLDASATASVAGLLGFLDAAETVENGLAPAPLAVARDRVQVLTVHSAKGLEWQVVAVAHLSGGTFPSTASRSTWLTDAAELPPLLRGDRAAAGALGIPVLDTSDVTNRKQLSDKISEHRRQLDQRRVDEERRLLYVAITRAEDTLLVSGHHWGATGVKPRGPSDFLVEIKDVIDRAAVAGDPCGTVEHWAPSPADGERNPLRDNVIEAVWPADPLAVRRDEVERGAALVRRALAAGPGRPCADVDGWAGDVDALLAERARLIEPPVRALPGQLSVSSLVGLARDPAGAAQRLRHRLPSRPDPHALLGNAFHSWVQKFYGAECLFDLGDLPGAADSDVGDSAELAALQTAFTESPWAARTPVAVEAPFEMPIGETLVRGRIDAVFADPDGGATVVDWKTGEPPHGAEALRQAAVQLAVYRMAWAALAGVAESAVRTAFYYVRAGTTVVPDELPSAAELAGLLTDPDGTRCDPRRPSIGEAVPVVT
>NZ_CP015278.1|WP_054585280.1|4672994_4676120_-|ATP-dependent-helicase
MAHTWEADASAVLAPGARGIVRVLGGPGTGKSSLLIDAAVAGIDAGIDPESVLLLTGSGRLGMAERSALTTALLRSRPGRVAVSEPLVRTVHGYAYAVLRRAAERAGDAPPRLVTSAEQDAIIRELLAGDLDDGARATSAWPAQLRPALSTAGFATELRNLLARCAERGIDPGELERLGRHCRRPEWIAAGQFARQYEQVMLLRAAVGTAAPEATTPALGAAELVGAALEAFAVDPELLAAERGRIRVLLVDDAQQLDPQAARLVRVLAAGAELALIAGDPNQAVFGFRGGEPAGLLDGDGPAVTLTTSHRCAPAVARAVSGIAARLPGGGAGRRIDGAGAGEGSVTVRLAASAHAEAAAIADALRRAHLVDGVPWSQMAVIVRSVPRAGARLPRALAAAGVPVAAAAATGPLAEEPAVRALLTVLLAAADGLDGQQALALLTGPIGRVDPVSLRQLRRTLQRANPDRPPGDFAELLVETLSGAVPPGPQFRSLRKVRAVLDAAARCHEAGEDPRYTLWDAWHRSGLQRRWLSVSERGGPAAAQATRDLESVTALFDITDDYVSRTSGASLRGLVEHVAALHLPNANLEPAATAGQVRVLSAHAAMGHEWDFVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTADASMRAPLVAEERRLLVAAMGRARRRLLVTAVDSDTGGADHAAALPSPFFFDIAQWADEDVETTALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDELARDCAATQLARLAKAGVPGADPAGWHGLTPVSTGEPLRGGGDVVTLTPSTLQTLTDCPLRWLAERHGGTNPRDLRSTIGSVVHALIAEPRRSESELLAGLERAWQHLPFAAQWHSDNELARHRAMLEAFVEWRSQSRGALTEVGVEVEIDGTLQTGDGEQVRLRGRVDRLERDAAGRLVIVDVKTGKSPVSKDDAQQHAQLAMYQLAVAEGLVAAGGDTVEPGGARLVYVGKAGAAGAVEREQDPLTADAGDEWRQVIRRAAAATAGPQFVARRNDGCTHCPIRPCCPAHTDGAAR
>NZ_CP015278.1|WP_080691230.1|4676207_4676444_+|hypothetical-protein
MVSRLQKEGLTTMTDEHGFPTDEAPEGDAVEQLRPADSDDDAGLDTDYVSARDREANEADVIEQAYVVSADDERDDDR
>NZ_CP015278.1|WP_042913116.1|4676489_4677275_+|alpha/beta-hydrolase
MTAKLYVHRYGPSGPARILALHGLTGHGQRWQHLSGLLPEIGLAAPDLLGHGRSSWAAPWTIDANVSALAALLDAQAGTPVVVVGHSFGAGLAMHLAAARPNQVSGLLLLDPAIGLDGAWMREIAEAMLSSPDYPDAEEARLEKVHGSWSDVEPALLEAELDEHLVALPNGRYGWRISLPAMMAYWSELARDAVLPPAQTPTILVRAKRTSPPYVTDELIAGLAQRLGSRFRLLDFDCNHMVPYAKPDGVAALARELLGAR
>NZ_CP015278.1|WP_014712233.1|4677277_4677589_+|DNA-methyltransferase
MAPVTDDQVERVRALVAAIPSGRVATYGDIASVAGLSSPRIVGWIMRTDSSDLPWHRVITASGRPARHLTTRQLELLRAEGVLARDGRIALREVRYEFPDGVL
>NZ_CP015278.1|WP_008259667.1|4677595_4678450_-|TIGR02569-family-protein
MTVEPPPDHVLSAFGLAGVKPVYLGASWEGGWRCGEVVLSLVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGTPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWGDVDIFIAADRAAWEERPLASVPPGARVAPATADAERSVELLNQLATLRKPTKSPNQLVHGDLYGTVLFVGTAAPGITDITPYWRPASWAAGVAVIDALSWGEADDGLIERWNALPEWPQMLLRALMFRLAVHALHPRSTAEAFPGLARTAALVRLVL
>NZ_CP015278.1|WP_042913117.1|4678485_4679673_-|adenylyltransferase/sulfurtransferase-MoeZ
MLSVSSLPPLVAPADHLTGDEVARYSRHLIIPGLGVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIVEFDVVEESNLHRQIIHGVADVGRPKAVSARESMLAINPLVDVRLHEVRLDSTNAVELFGCYDLIVDGTDNFATRYLINDAAVLAKKPYVWGSIYQFEGQISVCWEDAPDGRGLNYRDLYPEPPPPGTVPSCAEGGVLGIVCASIASVMSTEVIKLITGIGDSLLGRLMIYDALQMTYRTIAIRRDPSDASRPKITELVDYEQLCGAAADTPVGDATTITPRELRELLDSGKELALIDVREPVEFDIVHIDGAQLVPQSSINSGEGLAKLPRDRMPVLYCKTGVRSAQALAVLKQAGFADAVHLEGGIVAWAQQMQPDMILY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

756156 : 886874

Mycobacterium_phage(42.86%)

integrase,transposase

attL 768782:768799|attR 821854:821871

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_129560167.1\|756156_756519_-\|transposase	transposase	NA	NA	NA	NA
WP_089150873.1\|756506_758876_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	1.7e-85	36.2
WP_033718771.1\|758931_759228_-	DUF1490 family protein	NA	NA	NA	NA
WP_033718775.1\|759456_761745_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	4.3e-89	38.3
WP_033718759.1\|761809_762106_-	DUF1490 family protein	NA	NA	NA	NA
WP_007170255.1\|762187_762544_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_065018912.1\|762615_763437_-	hypothetical protein	NA	NA	NA	NA
WP_085981751.1\|763516_764533_-	AAA family ATPase	NA	NA	NA	NA
WP_033719466.1\|764529_766488_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_099459185.1\|766610_767351_-\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_007172144.1\|767618_767924_-	hypothetical protein	NA	NA	NA	NA
WP_042910679.1\|767920_768148_-	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_007172147.1\|768633_770124_+	type VII secretion protein EccB	NA	NA	NA	NA
768782:768799	attL	NA	NA	NA	NA
WP_007172148.1\|770197_771253_+	hypothetical protein	NA	NA	NA	NA
WP_007172149.1\|771242_774341_+	type VII secretion protein EccCb	A0A0A0RUH6	Bacillus_phage	1.2e-20	30.1
WP_007172150.1\|774337_774754_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_101930858.1\|774993_775287_+	PE domain-containing protein	NA	NA	NA	NA
WP_007172152.1\|775302_776784_+	PPE family protein	NA	NA	NA	NA
WP_007172153.1\|776862_777165_+	hypothetical protein	NA	NA	NA	NA
WP_042910680.1\|777213_777507_+	hypothetical protein	NA	NA	NA	NA
WP_007172155.1\|777503_778445_+	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_007172156.1\|779213_780095_+	MinD/ParA family protein	NA	NA	NA	NA
WP_007172157.1\|780091_781588_+	type VII secretion integral membrane protein EccD	V5UN55	Mycobacterium_phage	4.0e-11	26.3
WP_040624272.1\|781587_783225_+	S8 family serine peptidase	V5UPA7	Mycobacterium_phage	1.8e-60	35.1
WP_007172159.1\|783224_784769_+	type VII secretion protein EccE	NA	NA	NA	NA
WP_080691135.1\|784834_785656_+	DUF2637 domain-containing protein	V5UP70	Mycobacterium_phage	1.6e-17	32.1
WP_040624275.1\|785750_787154_+	type IV secretory system conjugative DNA transfer family protein	V5UN59	Mycobacterium_phage	3.0e-16	38.4
WP_007172162.1\|787353_787632_-	hypothetical protein	NA	NA	NA	NA
WP_007172163.1\|787731_788550_-	hypothetical protein	V5UQM8	Mycobacterium_phage	2.4e-10	28.8
WP_073877511.1\|788539_788923_-	hypothetical protein	NA	NA	NA	NA
WP_007172165.1\|789053_789500_+	hypothetical protein	NA	NA	NA	NA
WP_046182038.1\|789496_790579_+	hypothetical protein	NA	NA	NA	NA
WP_073877513.1\|790589_791513_+	hypothetical protein	NA	NA	NA	NA
WP_101930857.1\|791622_791865_+	hypothetical protein	NA	NA	NA	NA
WP_080691140.1\|792119_794774_+	hypothetical protein	NA	NA	NA	NA
WP_007172171.1\|794770_796930_+	hypothetical protein	NA	NA	NA	NA
WP_007172172.1\|796926_798732_+	AAA family ATPase	V5UQM2	Mycobacterium_phage	1.8e-53	27.2
WP_154074410.1\|798721_798895_-	hypothetical protein	NA	NA	NA	NA
WP_007172175.1\|799448_801245_-	DEAD/DEAH box helicase family protein	A0A2I5ARD8	Synechococcus_phage	8.2e-11	23.8
WP_007172176.1\|801291_802848_-	serine/threonine protein kinase	M1HJA5	Acanthocystis_turfacea_Chlorella_virus	1.9e-19	35.0
WP_046182041.1\|803054_808910_-	relaxase domain-containing protein	NA	NA	NA	NA
WP_007172179.1\|809205_809718_+	hypothetical protein	NA	NA	NA	NA
WP_007172180.1\|809745_810240_+	hypothetical protein	NA	NA	NA	NA
WP_073877504.1\|811439_811958_-	hypothetical protein	NA	NA	NA	NA
WP_101930856.1\|812029_812662_-\|transposase	transposase	NA	NA	NA	NA
WP_007172184.1\|812838_813309_-	hypothetical protein	NA	NA	NA	NA
WP_007172185.1\|813305_815507_-	hypothetical protein	NA	NA	NA	NA
WP_007172186.1\|815503_817228_-	hypothetical protein	NA	NA	NA	NA
WP_162839945.1\|817227_818697_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_007172195.1\|822476_822803_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
821854:821871	attR	NA	NA	NA	NA
WP_087139680.1\|823858_825128_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	3.7e-50	41.7
WP_040624281.1\|825215_825500_-	hypothetical protein	NA	NA	NA	NA
WP_040624304.1\|825629_826664_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	7.0e-31	31.5
WP_087139632.1\|826914_828062_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.2e-32	32.4
WP_033717415.1\|829183_829783_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_101930920.1\|830211_830823_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172201.1\|830898_831345_+	hypothetical protein	NA	NA	NA	NA
WP_042910691.1\|831459_832356_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_008263955.1\|832352_835298_-	RND family transporter	NA	NA	NA	NA
WP_007172204.1\|836243_836885_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172205.1\|837133_837298_+	DUF5078 domain-containing protein	NA	NA	NA	NA
WP_042909973.1\|837337_840271_-	MMPL family transporter	NA	NA	NA	NA
WP_008263966.1\|840267_840687_-	hypothetical protein	NA	NA	NA	NA
WP_033721600.1\|841294_842305_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_042909972.1\|844219_845494_-\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	4.8e-98	48.0
WP_042909917.1\|846339_847482_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_042909971.1\|847558_848215_-	transglutaminase family protein	NA	NA	NA	NA
WP_042909918.1\|848211_849669_-	cytochrome P450	NA	NA	NA	NA
WP_007172211.1\|851179_851632_-	hypothetical protein	NA	NA	NA	NA
WP_007172212.1\|851646_852159_-	hypothetical protein	NA	NA	NA	NA
WP_007172213.1\|852155_852491_-	hypothetical protein	NA	NA	NA	NA
WP_033721564.1\|852477_853869_-	DUF1446 domain-containing protein	NA	NA	NA	NA
WP_007172215.1\|853865_854039_-	hypothetical protein	NA	NA	NA	NA
WP_007172216.1\|854495_855650_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_033721567.1\|855690_856878_+	thiolase family protein	NA	NA	NA	NA
WP_033721568.1\|856889_857279_+	Zn-ribbon domain-containing OB-fold protein	NA	NA	NA	NA
WP_157679851.1\|857330_857876_+	hypothetical protein	A0A2P1JQX9	Mycobacterium_phage	6.7e-41	61.8
WP_007172220.1\|858269_859817_-	long-chain fatty acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	9.4e-48	29.6
WP_007172221.1\|859879_861079_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_136244867.1\|861718_862501_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_046184313.1\|862715_863516_-	enoyl-CoA hydratase	NA	NA	NA	NA
WP_007172224.1\|863903_865457_+	long-chain fatty acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.4e-35	25.2
WP_007172225.1\|865549_866608_+	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_033721541.1\|866952_868404_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_046184315.1\|868851_869463_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172228.1\|869519_870818_+	cytochrome P450	NA	NA	NA	NA
WP_007172229.1\|870829_871021_+	ferredoxin	NA	NA	NA	NA
WP_007172230.1\|871142_872201_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_046186391.1\|875090_876878_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	1.8e-82	36.1
WP_007172236.1\|877590_878829_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	1.9e-06	23.6
WP_007172237.1\|879161_879485_-	hypothetical protein	NA	NA	NA	NA
WP_165589952.1\|879652_880513_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_007172240.1\|880558_882124_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_087588774.1\|883795_885053_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.0e-68	53.7
WP_165589950.1\|885533_885929_+	hypothetical protein	NA	NA	NA	NA
WP_007172251.1\|885962_886100_-	hypothetical protein	NA	NA	NA	NA
WP_007172252.1\|886094_886874_+\|transposase	IS256 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

919653 : 973388

Staphylococcus_phage(33.33%)

integrase,transposase

attL 917246:917261|attR 954394:954409

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
917246:917261	attL	NA	NA	NA	NA
WP_046182709.1\|919653_922119_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909842.1\|922115_923339_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_033721569.1\|924499_926008_-	carboxylesterase/lipase family protein	A0A0M4JT58	Mollivirus	8.1e-28	32.8
WP_033721570.1\|926140_927037_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_007172283.1\|927089_927530_-	PaaI family thioesterase	NA	NA	NA	NA
WP_046182710.1\|927578_928226_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007172286.1\|928346_929840_+	acetyl-CoA acetyltransferase	NA	NA	NA	NA
WP_007172287.1\|929836_930934_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_007172288.1\|932455_933001_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_087139643.1\|935235_936499_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.9e-70	53.4
WP_046187034.1\|937660_940594_-	MMPL family transporter	NA	NA	NA	NA
WP_042909907.1\|940590_941001_-	membrane protein	NA	NA	NA	NA
WP_007172294.1\|941105_942299_-	cytochrome P450	NA	NA	NA	NA
WP_007172295.1\|942364_942946_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_033717424.1\|943591_944215_-	hypothetical protein	NA	NA	NA	NA
WP_087139652.1\|944199_944811_-	hypothetical protein	NA	NA	NA	NA
WP_101930934.1\|945452_946706_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	6.1e-29	31.1
WP_075630243.1\|947137_948373_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.7e-84	45.2
WP_069434871.1\|948906_949329_+	hypothetical protein	NA	NA	NA	NA
WP_007168379.1\|949832_950477_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007168380.1\|950526_950967_+	PaaI family thioesterase	NA	NA	NA	NA
WP_007168381.1\|951019_951916_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_019732564.1\|951963_952179_+	hypothetical protein	NA	NA	NA	NA
WP_042909903.1\|952708_954157_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	3.3e-55	36.1
WP_007168385.1\|954903_955494_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
954394:954409	attR	NA	NA	NA	NA
WP_007168386.1\|955581_956883_+	cytochrome P450	NA	NA	NA	NA
WP_074021704.1\|956894_957086_+	ferredoxin	NA	NA	NA	NA
WP_033717470.1\|957218_958235_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_033712834.1\|958427_959297_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_057969459.1\|959373_960078_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_074021707.1\|960104_960704_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007168393.1\|960907_961744_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_007168394.1\|961762_962686_+	hypothetical protein	NA	NA	NA	NA
WP_042909902.1\|962682_964329_+	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_007168396.1\|964403_965927_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_007168397.1\|965923_966892_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_075630242.1\|967069_968527_+	cytochrome P450	NA	NA	NA	NA
WP_042909899.1\|968523_969180_+	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_085981616.1\|969212_970829_+	long-chain fatty acid--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.6e-26	24.5
WP_042909895.1\|970877_972020_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_008256196.1\|972314_973388_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

996940 : 1046960

Staphylococcus_phage(42.86%)

integrase,transposase

attL 991843:991859|attR 1037445:1037461

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
991843:991859	attL	NA	NA	NA	NA
WP_046184758.1\|996940_998293_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	6.3e-32	34.6
WP_007168431.1\|998920_999247_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042909891.1\|1001829_1003065_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.0e-84	45.2
WP_007168435.1\|1003916_1004435_-	hypothetical protein	NA	NA	NA	NA
WP_101930905.1\|1004503_1005598_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_007168437.1\|1006989_1008156_-\|integrase	tyrosine-type recombinase/integrase	A0A2K9VF00	Mycobacterium_phage	1.6e-07	29.1
WP_007168443.1\|1011010_1011442_+	hypothetical protein	NA	NA	NA	NA
WP_007168449.1\|1014082_1015711_+	long-chain fatty acid--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	6.7e-28	25.3
WP_007168450.1\|1015763_1016705_+	R2-like ligand-binding oxidase	NA	NA	NA	NA
WP_007168451.1\|1016911_1017337_+	hypothetical protein	NA	NA	NA	NA
WP_101930904.1\|1017354_1018479_+	thiolase family protein	NA	NA	NA	NA
WP_007168453.1\|1018545_1019439_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_007168454.1\|1019469_1021089_+	acyl--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.1e-30	28.1
WP_050790029.1\|1021336_1022458_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_007168458.1\|1024132_1025350_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_074021181.1\|1025876_1026374_-	ATP-binding protein	NA	NA	NA	NA
WP_007168461.1\|1026481_1027888_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_007168462.1\|1027934_1028081_-	hypothetical protein	NA	NA	NA	NA
WP_007168467.1\|1030210_1030537_-	ferredoxin family protein	NA	NA	NA	NA
WP_007168468.1\|1030885_1031164_+\|transposase	transposase	NA	NA	NA	NA
WP_154074411.1\|1031160_1031316_+	hypothetical protein	NA	NA	NA	NA
WP_007168470.1\|1031391_1031841_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_040622630.1\|1033101_1034184_+	dihydrodipicolinate reductase	NA	NA	NA	NA
WP_136244823.1\|1036609_1036891_-	hypothetical protein	NA	NA	NA	NA
WP_167310147.1\|1037020_1037209_-	hypothetical protein	NA	NA	NA	NA
WP_157137495.1\|1037807_1038254_-	hypothetical protein	A0A220NQR7	Corynebacterium_phage	2.9e-10	40.8
1037445:1037461	attR	NA	NA	NA	NA
WP_075362207.1\|1038879_1039191_+\|transposase	transposase	NA	NA	NA	NA
WP_042910040.1\|1040527_1041592_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_007168486.1\|1044183_1044525_-	hypothetical protein	NA	NA	NA	NA
WP_007168487.1\|1044545_1044953_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_033711258.1\|1044956_1045229_-	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_042909886.1\|1045724_1046960_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	2.2e-84	45.0

DBSCAN-SWA_4

2087472 : 2152587

Mycobacterium_phage(16.67%)

integrase,transposase

attL 2098822:2098881|attR 2105822:2106089

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080691159.1\|2087472_2088138_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_087139680.1\|2088246_2089516_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	3.7e-50	41.7
WP_042911237.1\|2089545_2091660_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_080691160.1\|2091665_2092835_+	AAA family ATPase	NA	NA	NA	NA
WP_158090653.1\|2092973_2095451_+	LysR family transcriptional regulator	NA	NA	NA	NA
2098822:2098881	attL	NA	NA	NA	NA
WP_042909842.1\|2100068_2101292_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_046182709.1\|2101288_2103754_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909843.1\|2103750_2104038_+	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_042910261.1\|2105002_2105815_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	2.9e-32	33.5
WP_042910200.1\|2106787_2107159_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
2105822:2106089	attR	NA	NA	NA	NA
WP_042910201.1\|2107172_2108096_+	M56 family metallopeptidase	NA	NA	NA	NA
WP_087139686.1\|2108238_2108502_+	hypothetical protein	NA	NA	NA	NA
WP_154074414.1\|2108637_2108787_+	hypothetical protein	NA	NA	NA	NA
WP_139315491.1\|2108990_2109266_-	hypothetical protein	NA	NA	NA	NA
WP_082408970.1\|2109565_2110960_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.2e-48	35.4
WP_042910204.1\|2112092_2113511_-	NADH-quinone oxidoreductase subunit N	NA	NA	NA	NA
WP_042910205.1\|2113514_2115005_-	NADH-quinone oxidoreductase subunit M	NA	NA	NA	NA
WP_087139688.1\|2115008_2116856_-	hypothetical protein	NA	NA	NA	NA
WP_042910207.1\|2116852_2117155_-	NADH-ubiquinone oxidoreductase	NA	NA	NA	NA
WP_042910208.1\|2117151_2117715_-	NADH:ubiquinone oxidoreductase subunit J	NA	NA	NA	NA
WP_042910209.1\|2117718_2118654_-	NADH-quinone oxidoreductase subunit H	NA	NA	NA	NA
WP_072501252.1\|2118646_2119816_-	hypothetical protein	NA	NA	NA	NA
WP_042910211.1\|2119806_2120151_-	NADH-quinone oxidoreductase subunit A	NA	NA	NA	NA
WP_080691115.1\|2121434_2122601_+	PLP-dependent cysteine synthase family protein	A0A1W6JHY1	Lactococcus_phage	2.6e-34	33.0
WP_042910213.1\|2125006_2125306_+	PE family protein	NA	NA	NA	NA
WP_042910214.1\|2125320_2126496_+	PPE family protein	NA	NA	NA	NA
WP_042910215.1\|2126594_2126891_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_042910216.1\|2126899_2127184_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_051445804.1\|2127452_2128247_-	DUF1275 domain-containing protein	NA	NA	NA	NA
WP_072501503.1\|2128615_2129638_-	pyridoxal-phosphate dependent enzyme	NA	NA	NA	NA
WP_074021264.1\|2130248_2130440_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_042910217.1\|2134546_2136523_-	protein kinase	A0A2K9L111	Tupanvirus	1.1e-08	26.0
WP_042910219.1\|2136540_2137638_-	phosphate ABC transporter substrate-binding protein PstS	NA	NA	NA	NA
WP_051445801.1\|2137747_2139280_-	multicopper oxidase family protein	NA	NA	NA	NA
WP_072501253.1\|2139539_2140730_-	PPE family protein	NA	NA	NA	NA
WP_042910221.1\|2140752_2141046_-	PE family protein	NA	NA	NA	NA
WP_042910246.1\|2142730_2143978_+	MFS transporter	NA	NA	NA	NA
WP_080691117.1\|2146327_2147569_+	PLP-dependent cysteine synthase family protein	NA	NA	NA	NA
WP_054585452.1\|2147663_2148683_+	ornithine cyclodeaminase	NA	NA	NA	NA
WP_080691118.1\|2148757_2150041_+	amino acid decarboxylase	NA	NA	NA	NA
WP_087139692.1\|2150052_2151294_+	MATE family efflux transporter	NA	NA	NA	NA
WP_087139643.1\|2151322_2152587_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.9e-70	53.4

DBSCAN-SWA_5

2844386 : 2862386

uncultured_virus(33.33%)

integrase,transposase

attL 2839767:2839781|attR 2864155:2864169

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2839767:2839781	attL	NA	NA	NA	NA
WP_129560167.1\|2844386_2844749_-\|transposase	transposase	NA	NA	NA	NA
WP_089150873.1\|2844736_2847106_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	1.7e-85	36.2
WP_033718771.1\|2847161_2847458_-	DUF1490 family protein	NA	NA	NA	NA
WP_033718775.1\|2847686_2849975_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	4.3e-89	38.3
WP_033718759.1\|2850039_2850336_-	DUF1490 family protein	NA	NA	NA	NA
WP_007170255.1\|2850417_2850774_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_065018912.1\|2850845_2851667_-	hypothetical protein	NA	NA	NA	NA
WP_085981751.1\|2851746_2852763_-	AAA family ATPase	NA	NA	NA	NA
WP_033719466.1\|2852759_2854718_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_099459185.1\|2854840_2855581_-\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_072501290.1\|2856228_2857167_-	hypothetical protein	NA	NA	NA	NA
WP_082402557.1\|2857170_2858274_-	AAA family ATPase	NA	NA	NA	NA
WP_054585429.1\|2858198_2860076_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_087139680.1\|2860256_2861527_-\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	3.7e-50	41.7
WP_157679857.1\|2861624_2862386_-\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
2864155:2864169	attR	NA	NA	NA	NA

DBSCAN-SWA_6

3702002 : 3711092

Shahe_endorna-like_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042912268.1\|3702002_3703259_+	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	4.3e-06	34.4
WP_042912270.1\|3703266_3704046_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_009953302.1\|3704141_3704945_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_020822883.1\|3705060_3705867_-	methyltransferase MtfC	A0A2R8FDY2	Brazilian_cedratvirus	7.6e-57	53.1
WP_072501358.1\|3705962_3707249_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	1.2e-08	44.4
WP_042912274.1\|3707662_3708931_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	4.3e-06	38.7
WP_041298244.1\|3709022_3709829_-	macrocin O-methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	6.4e-56	53.1
WP_042912275.1\|3709982_3711092_-	NAD-dependent epimerase/dehydratase family protein	A0A2K9L0I7	Tupanvirus	8.9e-16	24.3

DBSCAN-SWA_7

4382405 : 4388981

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042912786.1\|4382405_4384571_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	3.3e-208	51.6
WP_008259183.1\|4384540_4384993_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	5.8e-14	40.2
WP_008259184.1\|4385024_4385264_-	redoxin NrdH	V5UN81	Mycobacterium_phage	1.3e-20	63.2
WP_008259185.1\|4385792_4386347_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.2e-05	34.4
WP_008259186.1\|4386438_4387053_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_008259187.1\|4387061_4388105_+	DNA polymerase IV	F1C5A5	Cronobacter_phage	3.9e-21	29.1
WP_008259188.1\|4388039_4388981_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.2e-05	28.8

DBSCAN-SWA_8

4957957 : 4966603

Burkholderia_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014385777.1\|4957957_4959484_+	cyclic nucleotide-binding domain-containing protein	W8CYF6	Bacillus_phage	1.3e-12	37.4
WP_042913325.1\|4959523_4960363_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_042913327.1\|4960359_4961226_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_008260499.1\|4961253_4962249_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	5.8e-75	46.5
WP_042913511.1\|4962250_4962868_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.3e-27	38.8
WP_042913329.1\|4963067_4964189_+	acyltransferase	A9YX16	Burkholderia_phage	2.9e-14	27.7
WP_042913331.1\|4964318_4965455_+	acyltransferase	A9YX16	Burkholderia_phage	2.6e-18	28.0
WP_042913512.1\|4965514_4966603_+	acyltransferase	A9YX16	Burkholderia_phage	1.3e-16	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP015279

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP015278

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection