CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Prophage number
NZ_CP022223	Mycobacterium chimaera strain SJ42 chromosome, complete genome	8 crisprs	DEDDh,cas3,RT,csa3,DinG,cas4,WYL,c2c9_V-U4,Cas9_archaeal	1	4
NZ_CP022224	Mycobacterium chimaera strain SJ42 plasmid unnamed1, complete sequence	0 crisprs	NA	0	0
NZ_CP022225	Mycobacterium chimaera strain SJ42 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022223_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_1

1387483-1387561

Orphan

Consensus_repeat	Method
TCCGCCGCGGAGGTCCGTGGGCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_1

>merge|NZ_CP022223|1|1387483-1387561|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCCGCTGCGCCTCATCGCTTCGCATTGCATCGTCCGCCGCGGAGGTCCGTGGCCGCC

>NZ_CP022223|1|1|1387483-1387561|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCC	GCTGCGCCTCATCGCTTCGCATTGCATCG
TCCGCCGCGGAGGTCCGTGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_008254760.1\|1394161_1395040_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP022223.1\|WP_008254755.1\|1393248_1393638_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP022223.1\|WP_020821956.1\|1388793_1389285_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NZ_CP022223.1\|WP_020821951.1\|1379123_1381745_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NZ_CP022223.1\|WP_051197806.1\|1386572_1387481_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP022223.1\|WP_051197713.1\|1383071_1384706_-\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP022223.1\|WP_020821961.1\|1395109_1395976_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_CP022223.1\|WP_020821948.1\|1376682_1377213_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP022223.1\|WP_020821950.1\|1377975_1379127_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NZ_CP022223.1\|WP_020821960.1\|1393681_1394095_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP022223.1\|WP_020821952.1\|1381840_1383085_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP022223.1\|WP_008254722.1\|1376116_1376674_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP022223.1\|WP_009955270.1\|1387603_1388581_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP022223.1\|WP_041320846.1\|1389363_1389804_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP022223.1\|WP_041320848.1\|1392745_1393231_+\|RrF2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
NZ_CP022223.1\|WP_020821958.1\|1389916_1390846_+\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_CP022223.1\|WP_008254752.1\|1390845_1392687_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
NZ_CP022223.1\|WP_020821949.1\|1377307_1377811_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NZ_CP022223.1\|WP_020821954.1\|1384740_1386576_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|182342
NZ_CP022223.1\|WP_089152388.1\|1374168_1375935_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_008254760.1\|1394161_1395040_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.86964e-30
NZ_CP022223.1\|WP_008254755.1\|1393248_1393638_-\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	4.24427e-67
NZ_CP022223.1\|WP_020821956.1\|1388793_1389285_+\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.82269e-65
NZ_CP022223.1\|WP_020821951.1\|1379123_1381745_+\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	7.65858e-09
NZ_CP022223.1\|WP_051197806.1\|1386572_1387481_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.7458e-85
NZ_CP022223.1\|WP_051197713.1\|1383071_1384706_-\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.21846e-158
NZ_CP022223.1\|WP_020821961.1\|1395109_1395976_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.00297791
NZ_CP022223.1\|WP_020821948.1\|1376682_1377213_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	3.73752e-31
NZ_CP022223.1\|WP_020821950.1\|1377975_1379127_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	2.57051e-64
NZ_CP022223.1\|WP_020821960.1\|1393681_1394095_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	3.94653e-12
NZ_CP022223.1\|WP_020821952.1\|1381840_1383085_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.67988e-10
NZ_CP022223.1\|WP_008254722.1\|1376116_1376674_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	4.57725e-31
NZ_CP022223.1\|WP_009955270.1\|1387603_1388581_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.50326e-99
NZ_CP022223.1\|WP_041320846.1\|1389363_1389804_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.31203e-31
NZ_CP022223.1\|WP_041320848.1\|1392745_1393231_+\|RrF2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.50922e-49
NZ_CP022223.1\|WP_020821958.1\|1389916_1390846_+\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP022223.1\|WP_008254752.1\|1390845_1392687_+\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_CP022223.1\|WP_020821949.1\|1377307_1377811_-\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	1.7589e-43
NZ_CP022223.1\|WP_020821954.1\|1384740_1386576_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|182342	PRK10261, PRK10261, glutathione transporter ATP-binding protein; Provisional.	1.48916e-168
NZ_CP022223.1\|WP_089152388.1\|1374168_1375935_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.04157e-159

>NZ_CP022223.1|WP_051197806.1|1386572_1387481_-|ABC-transporter-permease
MDGAHGFSSHDAADFTSRRTLVLRRFARNRFAVASLTLLVLLFVGCYTLPAVLPFSYEDLDFTALLQPPSARHWLGTNALGQDLLAQILRGMQKSMLIGICVAVISTGIAATVGSVSGYFGGWRDRVLMWLVDLLLVVPSFILIAIVTPRTKDSANIVMLVLLLAGFGWMVSSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVASAILAETGLSFLGFGIQPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVLILVCANLTGDGLRDALDPGSTPVRGGAR
>NZ_CP022223.1|WP_020821954.1|1384740_1386576_-|ABC-transporter-ATP-binding-protein
MSPLLEVTDLAVTFATGGDPVTAVRGVSYRVEPGEVVAMVGESGSGKSVSAMAVVGLLPEYARVRGSVRLHDTELLGLDDDAMSRFRGKTVGMVFQDPMSALTPVYTVGDQIAEAIEIHQPRVGRRAARHRAVELLELVGIAQPERRARAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAEVHDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAGLDPGCPFAPRCPLAIDECRLEEPELLPVGADHRAACIRTDQVGGRSAADIYGVSTTAQSVRPDDSSVVVRVRDLTKTYRLTKGVLRRRAGEVRAVDGVSFELREGRTLGIVGESGSGKSTTLHEILELTGPQSGSIEVLGTDVTTLSSASRRSLRRDIQVVFQDPVASLDPRLPVFELLAEPLRANGFDKGRTNARVAELLEIVGLRRADAIRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQALFGLSYLFVSHDLSVIKHLAHEVVVMRSGTVVERGDSRQVFDNPQHEYTRQLLNAVPRPDPGARG
>NZ_CP022223.1|WP_051197713.1|1383071_1384706_-|ABC-transporter-family-substrate-binding-protein
MALALSGCSPAINLIPETGQNARIGTSSDINPRDPATLRDGGDLRLALTAFPPNFNILHIDGNSAEVAAMMKATLPRAFVIGPDGSTTVDTNYFTSIELTGTAPQVVTYTINPKAVWSDGTPITWEDIASQVHALSGADKNFEIAGPSGAERVASVTRGVDDRQAVMTFAKPYAEWRGMFAGNGMLLPKSMTATPEAFNKGQLDGPGPSAGPFIATSLDRTTQRIVLSRNPKWWGPRPRLDNITYLVLDDAARLPALQNNTIDATGVGTIDQLTIAQRTKGITIRRAPAPAWSHITFNGAPGSILADKALRVAVSKGIDRQTIAKVVQYGLTSDPVALGNHIYVAGQKGYQDNSAVVPYDPAAAKRELDALGWKQVGQFREKDGRPLIIRDLFYDAQGSRQFAQIAQHSLAQIGVKLELVARAGSGFFTNYINVGAFDLAQFGWLGDAFPLSSLTQIYKSDGESNFGKIGSPQIDAAIERTLEELDPDRARALANDLDRLIWAEGFSLPLTQSPGDVAVRSTLANFGAAGLGDLDYTAIGFTRS
>NZ_CP022223.1|WP_020821952.1|1381840_1383085_+|alpha/beta-hydrolase
MTMNAKRSRVQQKLAELPGVRAVRRPISPHSADEFDLYYVRTGRKSRHPLVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRHDDSGADLPPQSMTVNQVVDDVAAVLDDAHADSADIYGASYGTYIAAGVGVRHPERVHAMVLDSPLLSRHDIVIVRRAIRRLLLRADSPETAALAPKMRKLVDAGVMTPAATHVVATIYGYGGADLLERQLDLLLQRRKLLWWTLSRFTTLSNLPFRYEEDLVSRIAFRELDYAAEPDGLPLDPAVAESEARTQRVTFEDEPYDLPTEMPNFNWPTAVISGGRDLITPPAVAERVASLLPDAVLLSLPSMAHSALDFREPVALAAADALGRGDLKGLAAQASTLDALPPRPEVRLLWKLIETAAAAEGALPVPTRLLRRLSCA
>NZ_CP022223.1|WP_020821951.1|1379123_1381745_+|AAA-family-ATPase
MKLHRLILTNYRGISHREIEFPDHGVVVVCGANEIGKSSMIEALDLLLESRDRSTKKEVKQVKPTHSDVGSEVSAEISCGPYRFVYRKRFHKKCETELAIITPCREQLTGDEAHERVRAMLAETVDSDLWHAQRVLQSTSTGAVDLSGCDALSRALDVAAGDSGGLCGTEPLLIERIDTEYARYFTPTGRPTGQWAAAIARLADAEAAVAECAAAVAEVDDRVARHAVLTEQVADFSQRRIAAGPRVAAAREAADRIAELTAQQREAQLVAAAAAATSAAATAAHTGRLQLLAEIDARAGAVAETEAQAHQAASAHASARAEAEACDATLQRATQVLADLQCRVDAARRGVDRLADLEEVDRLSTRLAKVDAIERDRERICAELSTIAVTEELLRRIEDACAAVDRIGDQLASTSAAIEFTAAADIHLVVGGERISLSAGQSWSITAAGSTVVEVSDVLTARVTPGATTLDIHAKHAAAQQEMTAALAAAEVADLAAARSADQRRRELVSTRDQLGATLAGLCGDEQIDEMRSRLARLRAQHPAEPAPGATDIGAARGELDAAQQGHAAASTDCEAHRQAATAAAAALAELSTRATVLQNTLEAQRAELQAAAGRLAAERASVSDEELAASADSALRAEQAADQRVGELAAALAAASPDAVAAELAEATKEAESLRERYEEAARALREITIELSVFGSEGRQGKLDAAETEREHAATEHSQIGARARAAKLLRSVMTRHRDTTRRRYVEPYRAELQRLGRPVFGPSFEVDIDSDLCIRSRTLNGITVPYESLSGGAKEQLGILARLAGAALVAKEDAVPVVVDDALGFTDPDRLAKMGQLFDSVGTHGQVIVLTCSPDRYDGVRGAHRIDLTA
>NZ_CP022223.1|WP_020821950.1|1377975_1379127_+|exonuclease-SbcCD-subunit-D
MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLRALAAEVGAEFVVVSGDVFEHNQLPPTVIGQSLEAMRAIGIPVYMLPGNHDPLDASSVYTSALFAAERPDNVVVLDRAGVHQVRPGLEIVAAPWRSKVPTTDLVADVLDGLPAAAGTRILVAHGGVDVLDPDKDKPSLIRLATLDDALSRGAVHYVALGDKHSLTQVGDSGRVWYSGSPEVTNFDDVESDPGHVLVVDVDETDPRGAVSVTARDVGRWRFVTLHRQVDTSRDIADLDVNLDLMTDKDRTVVRLALTGSLTVTDRAVLDACLDKYARLFAWLGLWERHTDLAVIPADGEFSDLGIGGFAAAAVEELVATAREEDSATAVDAQAALALLLRLADRGAA
>NZ_CP022223.1|WP_020821949.1|1377307_1377811_-|histidine-phosphatase-family-protein
MTAERTLLLMRHAKSDYPAGVADHDRPLAPRGVRQAALAGDWLRAHVPPVDGVLCSTATRTRETLRNTRIDAPVRYSERLYASTPGTLIDEINTVDDGIGTLLVIGHEPTMSALALGLGRAGGTDAAAAERISAKFPTSAIAVLAVPCAWKELELGGASLIDFVVPR
>NZ_CP022223.1|WP_020821948.1|1376682_1377213_+|DUF3558-domain-containing-protein
MRAAAVLLLAALLVLTGCSRSIGGNAVKAGGNVPRNNNSQQQYPNLLKECEVLTSDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGSLSNERKVAEFLKYKIESRPIAGIDSIVMRPDDANGACGVASDAAGVVGWWVNPQAPGIDACGQAIKLMELTLATNS
>NZ_CP022223.1|WP_008254722.1|1376116_1376674_+|DUF3558-domain-containing-protein
MRRSARALALVASALTILIPAVAACSDSGGNKPGATASSTPQKGQGNHGPMFPQCGGISDQTVAELTRVTGLINTARNSVGCQWLAGGGILGPHFSFSWYRGSPIGRERKTEELSRASVDDININGHGGFIAVGNEPNLGDSLCEVGIQFQDDFIEWSISFSQKPFPPPCDIAKELARQSIANSK
>NZ_CP022223.1|WP_089152388.1|1374168_1375935_-|ABC-transporter-ATP-binding-protein
MLLALLRQYIQPYRRLVAVLMVLQLISNLASLYLPTVNAAIIDEGVAKGDTAAIVRLGIVMLGATGLQVLCSVGAVYFGSRTGMGFGRDLRAAVFEHVLTFSERESARFGAPTLLTRSTNDVRQIQYLVQITATVLVTAPIMCLGGIVMALRQEAALTWLLLVSVPVMAVTNYWVMSHMLPLFRRMQGLIDGINRVMRDQLAGVRVVRAFAREGFERDRFARANAALSNTALTAGNWQALMLPVTTLTINVSSVALIWFGGLRIDRGQMQVGSLTAFLAYFTQILMAVLMATMTLVVLPRASVCAERITEVLTTRPAVTDPPGPASPPGKITGVVRLDGATFTYPGADRPVLQDISFIARPGTTTAIVGSTGSGKSTLISLICRLYDVTGGTVLVDDIDVRDYHTERLWSAIGLVPQRGYLFSGTIADNLRYGAAPGHDITGDEMWEALRVADADGFVRAHPDGLQMRVAQGGINFSGGQRQRLAIARAVIRRPAVYLFDDSFGALDVHTDARVRAALKPISKEATVIVVTQRVSTAAQADQVVVVDGGRLVGAGTHESLLADSATYAEFADSQAVGALPSGHVGGAQ
>NZ_CP022223.1|WP_009955270.1|1387603_1388581_-|ABC-transporter-permease
MTRFLARRLLNYVVLLALASFLTFCLTSVAFKPLDSLLQRNPRPPQAVIDAKAHALGLDEAIPIRYAHWASHAVRGDFGKTVTGQPVGESLWRRVGVTLRLLVIGSLVGTVAGIAAGAWGAIRQYRLSDRVVTMVALLVLSTPTFVIANLLILAALRVNWAVGLQIFDYTGETSPGVSGGAGAHFFDRLRHLVLPSLTLALAAAAGYSRYQRNAMLDVLGQDFIRTARAKGLTRRRALVKHGLRTALIPLATLFAYGVAGLVTGAVFVEKIFGWHGMGEWLVQGIATQDTNIVAAITVFSGAVVLLAGLLSDVFYAALDPRVRVS
>NZ_CP022223.1|WP_020821956.1|1388793_1389285_+|carbonic-anhydrase
MTVTDDLLANNAEYAKTFNGPLPMPPGKHVAVVACMDARLDVYRLLGLNEGEAHVIRNAGGVVTDDVIRSLAISQRLLGTREIILIHHTDCGMLTFTDDDFKRSIQEETGVKPPWAAEAFPDVAEDVRQSLRRIEGSPFVTKHVSARGFFFDVATGKLNEVTL
>NZ_CP022223.1|WP_041320846.1|1389363_1389804_-|PaaI-family-thioesterase
MTSHSGPSRPPAPSGRDVIAQFLPQSPFVVKLGIVADRLEEDEVRLRLPWDPSNVTIGDMVHGGAIATLADLTVMAAAWCGVPAPPELRGVTVSMALDYMAPARATDVIGIGRVLRRGRSLVNCEAEIVDSGGTLVAKALATYKVG
>NZ_CP022223.1|WP_020821958.1|1389916_1390846_+|sulfate-adenylyltransferase-subunit-CysD
MTSDLKTAPAVGQYELSHLRSLEAEAIHIIREVAAEFERPVLLFSGGKDSIVMLHLALRAFRPGRLPFPVMHVDTGHNFDEVIATRDELVKEHGVRLVVASVQEDIDAGRVVEPRQGRNPIQTVTLLRAIRENKFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAENIALPSIYYAHRRKVFRRDGMLLAVDKNMQPNADEPVFEATVRFRTVGDVTCTGCVESQAATVEEVIAETAVSRLTERGATRADDRISEAGMEDRKRQGYF
>NZ_CP022223.1|WP_008254752.1|1390845_1392687_+|adenylyl-sulfate-kinase
MATLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDKEKFEAIRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNMVDVRFPVQYVIRPHTREHQDHRSYAGTVASGVMRAGDEVVVLPVGKHTRITAIEGPNGPVEEAFPPMAVSVTLADEIDISRGDLIARTHNQPRVAQEFDATVCWMADGAALEPGRDYVIKHTTRTTHAKVTALDYRLDVNTLHRDKSATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKPSAIAQARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGSLAYVLDGDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFEFIEVFCDTPIDECEKRDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLTPDGTIEEQAQRVLDLLESRG
>NZ_CP022223.1|WP_041320848.1|1392745_1393231_+|RrF2-family-transcriptional-regulator
MRMSAKAEYAVRAMIQLATVPDGTLVKTDDLAQAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARSGSDISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRSVLEQTTLADVATGGLPKHVAQLADDYRKQESQRHGSARTGD
>NZ_CP022223.1|WP_008254755.1|1393248_1393638_-|VOC-family-protein
MSISFNHTIVASRDKRESAEFLTELFGLPSPKPFGHFMVVELEHGATLDYADAPDGADIPRQHYAFLVSEQEFDTIYDKIRARGMQHWADPGATRPGEINHNDGGRGVYFTDPSGHAMEILTRPYGSGG
>NZ_CP022223.1|WP_020821960.1|1393681_1394095_-|VOC-family-protein
MDFTSTSIAHVRLTVTDIERSRQFYESVFGWPVLLEVPDNADEATRNQLSFLFGGVIYDLGGTLLGLRPVAAGRFDENRVGLDHIAFRLTTRDELDSAAAHLDELGVAHEPIKDIGPSYILEFRDPDNIALELTAPK
>NZ_CP022223.1|WP_008254760.1|1394161_1395040_+|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDATVLETWARTIDEGPFSSLCWGERIAFDNPDNLTLLGALAAWTDRVRLLTTVIVPQLHDPVMLAKGLATGDMLSGGRLTVGIGVGGRHEDYHAVGADPATQTMRGMAERVAVMKRVWAGEKTTDSVRPVGPAPVQPGGPPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQNELFDVTRDAWARAGKPKPHLITSFWFAFGSPEESRAQVHRHLRRYMNWIPAEYVDAMAPMTGWAGSEDELLDVLRRFEEIGTDEVQLIPTSSDVDQLRRAAEVAGRL
>NZ_CP022223.1|WP_020821961.1|1395109_1395976_+|tetratricopeptide-repeat-protein
MTQQELPAPLAEMTGLMARCANNGDFAGAALQANELVTLCRATLGERDPNVLELKVALATVQLRAGEDADVYADLDALIPDLVAVLGPDHLSTLTARHLFAGRQQPPVSSLSEWSQLVADEQRILGPDHESTLMARERVAEKRWETGDFAGAMTEGQHVLAARRRVLGDDHADTLGTRLMLAIWRGRAGDIPGAITELEWLIGELRDKLGSGHVHLLMARHMFTLWAPKRAGVTDGVTAWEALVEEEARVLGDEHPVTIAARQELAGWCARHRARAGEPDTPVDWSAS

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Crispr_ID: NZ_CP022223_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_2

2371216-2371329

Orphan

Consensus_repeat	Method
GGTGTGATCGCGGCTTCGCCGCTCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_2

>merge|NZ_CP022223|2|2371216-2371329|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACA

>NZ_CP022223|2|2|2371216-2371329|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACA	TGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCG
GGTGTGATCGCGGCTTCGCCGCTCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_003878110.1\|2368633_2368924_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP022223.1\|WP_008256148.1\|2366980_2367757_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402
NZ_CP022223.1\|WP_008256158.1\|2370418_2371093_-\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|224837
NZ_CP022223.1\|WP_089151680.1\|2363789_2364752_+\|cell-division-protein-FtsQ/DivIB	unknown	unknown	gnl\|CDD\|224505
NZ_CP022223.1\|WP_008256160.1\|2371725_2373246_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP022223.1\|WP_008256169.1\|2380414_2380849_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350222
NZ_CP022223.1\|WP_014711465.1\|2377481_2378960_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_008256156.1\|2370076_2370415_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|376764
NZ_CP022223.1\|WP_041297812.1\|2374674_2376228_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP022223.1\|WP_008256170.1\|2380852_2381101_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|226603
NZ_CP022223.1\|WP_008256168.1\|2379534_2380020_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP022223.1\|WP_008256146.1\|2365019_2366177_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NZ_CP022223.1\|WP_008256163.1\|2377119_2377329_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_008256153.1\|2369186_2369984_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226127
NZ_CP022223.1\|WP_089151679.1\|2362311_2363790_+\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_CP022223.1\|WP_089151682.1\|2366228_2366975_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|224413
NZ_CP022223.1\|WP_008256149.1\|2367823_2368468_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|224712
NZ_CP022223.1\|WP_014711466.1\|2378956_2379535_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_014711299.1\|2373865_2374678_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NZ_CP022223.1\|WP_008256161.1\|2376501_2377047_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_003878110.1\|2368633_2368924_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	1.05966e-07
NZ_CP022223.1\|WP_008256148.1\|2366980_2367757_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	5.32837e-80
NZ_CP022223.1\|WP_008256158.1\|2370418_2371093_-\|phosphoribosyltransferase	gnl\|CDD\|224837	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only].	2.3221e-93
NZ_CP022223.1\|WP_089151680.1\|2363789_2364752_+\|cell-division-protein-FtsQ/DivIB	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	2.07895e-51
NZ_CP022223.1\|WP_008256160.1\|2371725_2373246_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	7.40832e-09
NZ_CP022223.1\|WP_008256169.1\|2380414_2380849_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350222	cd09874, PIN_MT3492-like, VapC-like PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis CDC1551, hypothetical protein MT3492, and similar bacterial and archaeal proteins are included in this subfamily. They are PIN domain homologs of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	6.48694e-28
NZ_CP022223.1\|WP_008256156.1\|2370076_2370415_+\|phage-holin-family-protein	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	0.00469149
NZ_CP022223.1\|WP_041297812.1\|2374674_2376228_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.31673e-18
NZ_CP022223.1\|WP_008256170.1\|2380852_2381101_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	1.06686e-14
NZ_CP022223.1\|WP_008256168.1\|2379534_2380020_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.54471e-06
NZ_CP022223.1\|WP_008256146.1\|2365019_2366177_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NZ_CP022223.1\|WP_008256153.1\|2369186_2369984_+\|DivIVA-domain-containing-protein	gnl\|CDD\|226127	COG3599, DivIVA, Cell division initiation protein [Cell division and chromosome partitioning].	5.87672e-33
NZ_CP022223.1\|WP_089151679.1\|2362311_2363790_+\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_CP022223.1\|WP_089151682.1\|2366228_2366975_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|224413	COG1496, yfiH, Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism].	4.13809e-99
NZ_CP022223.1\|WP_008256149.1\|2367823_2368468_+\|cell-division-protein-SepF	gnl\|CDD\|224712	COG1799, COG1799, Uncharacterized protein conserved in bacteria [Function unknown].	8.63087e-45
NZ_CP022223.1\|WP_014711299.1\|2373865_2374678_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	1.13871e-34

>NZ_CP022223.1|WP_008256158.1|2370418_2371093_-|phosphoribosyltransferase
MNRPNGFLRRTATRNFRDRREAGRALAEELTSYRGRDVLVFGLARGGVPVAWEIAAALGAPLDVFLVRKLGVPNWSELAMGALASGGGLVMNDDVVASLRVTDEQVREVIDSETTELLRREHAYRGGRPIADPRDRVVILADDGIATGASMLAAVRAVRAAGPESITVAVPVGPESACRDLAREADDVVCATMPPGFEAVGQVYDDFHQVSDDEVRELLATPTA
>NZ_CP022223.1|WP_008256156.1|2370076_2370415_+|phage-holin-family-protein
MLVIALVLALIGLVALVFAVVTSNELVAWLCIAASVVGVVLLILDALRERQHREPGGAEAQDAGEARPDEDDYVDYPEEAAAEGEAEAVTDGTEATEESSVAAEGRGDESAK
>NZ_CP022223.1|WP_008256153.1|2369186_2369984_+|DivIVA-domain-containing-protein
MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVEAELTRLIEENSDLRQRIEELDQELASGGGAAAPAAAAAPTQAIPVREPEPEPVKAAAAPAAAVNNEEQAMKAARVLSLAQDTADRLTSTAQAESEKMLSDARANADQILSEARSTAETTVAEARQRADAMLADAQTRSETQLRQAQEKADALQADAERKHSEIMGTINQQRTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSADAGGFDQFNRGNN
>NZ_CP022223.1|WP_003878110.1|2368633_2368924_+|YggT-family-protein
MVLFFQILGFALFIFWLLLIARVVVEFIRSFSRDWHPTGITVVVLEIIMSITDPPVKLLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAA
>NZ_CP022223.1|WP_008256149.1|2367823_2368468_+|cell-division-protein-SepF
MSTLHKVKAYFGMAPMDDYEDEYYDDRAPSRGFPRPRFDDGYGRYDGDDYEDPRREPADYPPPAGYRGGYADEPRYGSVHPREFDRAERGGPRFGSWLRNSTRGALAMDPRRMAMMFEEGHPLSKITTLRPKDYSEARTIGERFRDGTPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
>NZ_CP022223.1|WP_008256148.1|2366980_2367757_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MAVDMSNGGDRESELTHALAAVRSRLAAAAQAAGRNAAEIEVLPITKYFPAIDVVTLSRLGCRAVGESRDQEATAKVAEVTRLLAAPERANVGNPRWHMVGHIQRNKARSVAGWAHTAHSVDSTQLVTALDRGVAAALAEGRRTDPMRIYVQVSLDGDESRGGVDISRPGAVDQMCAQVEEASNLDLAGLMAIPPLDSDPDEAFDRLQSEHRRVLESHRNAVGLSAGMSNDFEIAVKHGSTCVRVGTALLGRRRLPSP
>NZ_CP022223.1|WP_089151682.1|2366228_2366975_+|peptidoglycan-editing-factor-PgeF
MQPGRQQLPDTDHVSVRVRRVTTTRAGGVSKPPFDTFNLGDHVGDDPAAVAENRARLAAAVGLRPGRVVWMNQVHGDRVEVVDGPREAAVEDTDALVTRTARLALAVVTADCVPVLMADARAGVAAAVHAGRVGAQRGVVARTVEAMLELGAQPDDISALLGPAVSGHNYEVPEAMADEVEAALPGSRTVTGAGTPGLDLRAGIACQLKGLGVTAIDIDPRCTVADPTLFSHRRDAPTGRLASLVWME
>NZ_CP022223.1|WP_008256146.1|2365019_2366177_+|cell-division-protein-FtsZ
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRRAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRGNQAESGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHQDANIIFGTVIDDSLGDEVRVTVIAAGFDATGPGRKPVIGGNADKEEKVGAHRIESAKAGKLTSTLFEPVDAVSVPVHTNGSTLNIGGDDDDVDVPPFMRR
>NZ_CP022223.1|WP_089151680.1|2363789_2364752_+|cell-division-protein-FtsQ/DivIB
MTQPLDPGTPGGGAGQADDPVPDDAATEPLVTGTGTEPTATDQQPDPAEVEGPRRRARRERAERRAAQARAMAIEEARREAKRRATGRPIHEPKPVARGVVRGLKMLLVTILLVIVGIGLALVLYFTPAMSARNIVVVGTGVVTREEVLDAAQVRLGTPLLQINTSQVADRVAAIRRVASARVQRQYPSALRITIVERVPVAVKDFPDGPHLFDRDGVDFATGPPPPALPYLDVADPGPNDPATKAALQVLTALRPEVADQVGRVAAPSVASITLTLGDGRVVIWGTTDRTDEKAEKLSALLTQPGKTYDVSSPDLPTVK
>NZ_CP022223.1|WP_089151679.1|2362311_2363790_+|UDP-N-acetylmuramate--L-alanine-ligase
MTTEQLPPELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGIHALRARGARINIGHDASSLDLLPGGATAVITTHAAIPKTNPELVEARRRGIPVILRPAVLAKLMDGRTTLMVTGTHGKTTTTSMLIVALQHCGRDPSFAVGGEMGEAGTNAHHGSGDCFVAEADESDGSLLEYTPNVAVVTNIETDHLDFYGSAGAYVDVFDAFVDRLAPGGALVVCVDDPGAAALARRTAELGIRVLRYGSGTSFPGEPLAATLLLWQQQGTEAVAQIQLAPDLDPEQRPRVMRLSVPGRHMALNAMGALLAALEIGAPVDAVLDGLAGFEGVRRRFELVGTAGNGQPVRVFDDYAHHPTEIVATLAAVRTLLEQSGDGRSIAVFQPHLYSRTKAFAEEFGHALDAADEVFVLDVYGAREQPLAGVSGASVAGHVSVPVRYLPNFSAAAEQVAAVAGPGDVIVTMGAGDVTLLGPEIVTALRARANRGAPGAL
>NZ_CP022223.1|WP_008256160.1|2371725_2373246_-|ATP-binding-protein
MSFRRSHRFGELVEAIYHATSTTTPETHWVEWKSTLDFSKAKDKVSAAKAIIALANRDPANAARECEGEGYLVVGVSPDGVLGAVAVHDAADLAGMLRTYVDGPHWDVDYVEFHGQLVLIITVAPPQPGHRIHSLVKDYESYKSGTVFRRGISGSEPATHRELNELQNRLLQDPPVSDSDAFDEAIGNGNYRLAGRLMRSAARGVIDACSNPEQFPPGFASRVPTKQITQYVEIADGYCETAAPLLPLVIEGCRVESTTLEVEYRQVITALAEPRPLAQESGSLITAVRNQQLEALALLPATLTIYAGTIAAIEHENYGAVRALTVDWSLFTNRKVAVLDKAGPWEIVGRERHLGLALRAAQTGVLTEQLLDALAAGRLPRRPVYPVSAFLFDALRSYFPDHTDSQYIRLFDASELLFALLVTDLAAQRSPGLLDQPWLGLFVAHAAECYPFEETEVAHTLVDARNAGDQWPAVEAGLFGGSKKRLQEAVDTVWTATVAQLRRGPF
>NZ_CP022223.1|WP_014711299.1|2373865_2374678_-|ATP-binding-protein
MSPQRPDATPAVKPIEVSGELKALMRRLKLGQLLDTLPERLALARTNRLPHHDFLELLFADEVTRRDRESATRRAKAAHLDPAMQLQAWDDSAAVAFDQQLWAELTSLRFLADAYNVLVMGPVGVGKTFLANALGHIAVRRHHSVHIERADKMFKRLRGARLDGSYEDEMRKLHRVELLIIDDLALHRLEATETTDFYEIIVERHRAASTVITSNREPPEILTMMADPLLAQSAMDRLQSAAYELVVEGESYRQRQKPGNRKPASPTASD
>NZ_CP022223.1|WP_041297812.1|2374674_2376228_-|IS21-family-transposase
MSYREVSVIEIVEMLRLWLQGLGLREVARLSGTDRKTVRRYVDRARASGLDRDGGDGQLTDELIAAVIAGVRTHRPSGKSLAWETIAAEHEQIKAWLKDGLTLTKIHTLLGRRGVVVSYRTLNRYVTTELDFGRRQATVPVADCEPGAEVQVDFGRLGMLTDASDGRRRVVQGLIFTAAYSRHMFVWPTYRQTLNDVIAGFEAAWAFFGGVFAVVIPDNMKAIVTTAHATEPRLNDAFREYAQARGFAVDPARVRSPKDKPRVERMVQYVRSNFFAGEDFRDLNDCRSRAEHWCAQTAGMRIHGTTRLRPAEVFIGDELPALGPVPDTAFDVPIWTRPKVAPDRHVQVAKALYSVPGELVGKRIEARADAHSVKLYWRGELIKVHPVVAPGRRHTDPADLPSEVSVYAMRDLNALQRKAAAQGTHVGTYAAAVLEHPLPWTKMRQVYRLLGLVRRHGAEEVDDACRRALDAEVIDVGLIERILTRGGGEQLPLLPKPPGAASRFVRESSDFAVRRPS
>NZ_CP022223.1|WP_008256161.1|2376501_2377047_-|hypothetical-protein
MSQWTVTHLEPNDRRNPAAGYITVAVDQSSEAAARQVFAETVRVAEMLEYATVQLRCDGVIVERWPVVTGDDPDLSDLRRAAALISHRGTNHSDGLHWSLTEAAESGRLAQLLRAVDFAYRVVIQYFALDVQTIDSQIHRFSTAPAADSFDVYNRYAAQAIEAMRAEDRARLNKRLRRRES
>NZ_CP022223.1|WP_008256163.1|2377119_2377329_+|hypothetical-protein
MRSTFRCAFFDEWTPAVLICQELQIFEGVCEHRSLKGFVRLIAKWREVCTNEMPMQPQTFLDLTALAAR
>NZ_CP022223.1|WP_014711465.1|2377481_2378960_-|hypothetical-protein
MNIDVPPEMYGNDPAGFIDHLGLVVLRRPIGSDTVWEVSAKHTDLVSAQTLHGPALKRSRFDVSPAPTPDVPGGMPPKLSDTFDKITQALDENPALAARLDRIITTLIAVPDHQVPAAIEWGSAALSRIPLERADGATEPLFPRLSVHDVRIDPLAYRWSKLPQVLLRLRHTTAAELVEESKQNPEKATFQSSGALLEGTVFGGLYFAPLLGSQSPSMWGIGVPRVGQVIVYTFGRLINGRGFGASRDPLDCLRVLIHHSPTHDFANTIADASDMHRAIFSETVDWWASRVDKTINDIFSPTTYLDAKNTYVPEAHQRWMLNLEQLITRIGAILSHPRDRSAQLMLMFPAMDLLADSFTGANGIGQLMTPTRLAKRIKAIEEHVPTRIKPLVMAPAYRALTAAQQVSDEFFAPSSNPDATTESRLIHLWNARRNTTHGFNENAEILAEHTGRLPADIVFVPMVYLLDILTDRERLLQRIARGCRTAHPGRTS
>NZ_CP022223.1|WP_014711466.1|2378956_2379535_-|hypothetical-protein
MRRDQLEHAIRTACQITAQTEVIVIGSQAILGTYPEYELPHLATRSMEVDILPITDDNNTTIELADLIVGVAGELSPFEQTHGFSIDGVDLTTAALPEGWRDRLVKVQNANTAAPSGDPQFIGWCLDKEDLCVAKLCAFRPKDQNFVQALIQEHLVDPVVITDRLGTVNARYTTAIETATRWLAYQIDNGPS
>NZ_CP022223.1|WP_008256168.1|2379534_2380020_-|helix-turn-helix-transcriptional-regulator
MAATGMSQSQLARISGVRQPSISQFLSGTIDFSDDQIDRLLSCMGYRLEVSRQAVNANLTRSERRSWSMHRQLATHLNATSLTAWQPTIFANIARLRAGVRGQPHLANLDHWQHLVSTKDVPALRRILTGVDRHSIEMREVTPMGGILTDEERRQALRNAV
>NZ_CP022223.1|WP_008256169.1|2380414_2380849_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MPLVYFDASAFVKLLTTETGSWLASALWDGCDAALSSRLAYPEVRAALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGRLARAHALRGADAVHLASASAVGDPGLIVAVWDRRLHTGAQAAGCRVAPAQLDP
>NZ_CP022223.1|WP_008256170.1|2380852_2381101_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MTELRAHLSDWLDRVRAGGEVVITDRGIPVARLAALDSAGNLERLAAEGVIGKATAQRPVAAGRSRPRPRRPVSDRVSDQRR

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Crispr_ID: NZ_CP022223_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_3

2997876-2997972

Orphan

Consensus_repeat	Method
GCGTTCGGGTCGACGGGCGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_3

>merge|NZ_CP022223|3|2997876-2997972|CRISPRCasFinder
GCGTTCGGGTCGACGGGCGGTGGTGGCGGCGCGTTGGGGTCGACGGGCGGTGGTGGGGGACAGGTGGGGGGGGGGCGTTGGGGTCGACGGGCGGTGG

>NZ_CP022223|3|3|2997876-2997972|CRISPRCasFinder
GCGTTCGGGTCGACGGGCGGTGG	TGGCGGCGCGTTGGGGTCGACGGGCGGTGGTGGGGGACAGGTGGGGGGGGG
GCGTTGGGGTCGACGGGCGGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_009956132.1\|3000532_3001195_+\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|378480
NZ_CP022223.1\|WP_014382609.1\|2991534_2992383_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181136
NZ_CP022223.1\|WP_014380167.1\|2998392_2999496_-\|sulfate/molybdate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224043
NZ_CP022223.1\|WP_009953028.1\|2982838_2984071_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP022223.1\|WP_014380173.1\|3005495_3005711_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_008256923.1\|2996678_2996978_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP022223.1\|WP_014380169.1\|3000291_3000543_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_014382610.1\|2992413_2994777_+\|phosphoketolase-family-protein	unknown	unknown	gnl\|CDD\|235379
NZ_CP022223.1\|WP_008256934.1\|3002195_3002873_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|135642
NZ_CP022223.1\|WP_009956128.1\|3005108_3005531_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP022223.1\|WP_014942152.1\|2994838_2995597_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP022223.1\|WP_094080968.1\|2986316_2987801_-\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|236204
NZ_CP022223.1\|WP_094080970.1\|2995603_2996632_-\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|131869
NZ_CP022223.1\|WP_094081127.1\|2987894_2990297_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP022223.1\|WP_009953029.1\|2984044_2986204_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|138873
NZ_CP022223.1\|WP_009956130.1\|3003085_3003466_+\|DUF4189-domain-containing-protein	unknown	unknown	gnl\|CDD\|372741
NZ_CP022223.1\|WP_009956129.1\|3003672_3005058_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP022223.1\|WP_009956131.1\|3001231_3002008_-\|molybdate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270256
NZ_CP022223.1\|WP_009956134.1\|2999505_3000270_-\|molybdate-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|130643
NZ_CP022223.1\|WP_094080969.1\|2990509_2991433_+\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_009956132.1\|3000532_3001195_+\|DUF2510-domain-containing-protein	gnl\|CDD\|378480	pfam10708, DUF2510, Protein of unknown function (DUF2510). This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	8.39115e-06
NZ_CP022223.1\|WP_014382609.1\|2991534_2992383_+\|SDR-family-oxidoreductase	gnl\|CDD\|181136	PRK07825, PRK07825, short chain dehydrogenase; Provisional.	1.00832e-145
NZ_CP022223.1\|WP_014380167.1\|2998392_2999496_-\|sulfate/molybdate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224043	COG1118, CysA, ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism].	3.10877e-103
NZ_CP022223.1\|WP_009953028.1\|2982838_2984071_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.44259e-77
NZ_CP022223.1\|WP_008256923.1\|2996678_2996978_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	2.69685e-12
NZ_CP022223.1\|WP_014382610.1\|2992413_2994777_+\|phosphoketolase-family-protein	gnl\|CDD\|235379	PRK05261, PRK05261, phosphoketolase.	0
NZ_CP022223.1\|WP_008256934.1\|3002195_3002873_+\|SDR-family-oxidoreductase	gnl\|CDD\|135642	PRK05884, PRK05884, SDR family oxidoreductase.	2.88254e-136
NZ_CP022223.1\|WP_009956128.1\|3005108_3005531_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	8.4481e-30
NZ_CP022223.1\|WP_014942152.1\|2994838_2995597_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.42843e-09
NZ_CP022223.1\|WP_094080968.1\|2986316_2987801_-\|acetyl-CoA-acetyltransferase	gnl\|CDD\|236204	PRK08257, PRK08257, acetyl-CoA acetyltransferase; Validated.	0
NZ_CP022223.1\|WP_094080970.1\|2995603_2996632_-\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|131869	TIGR02822, putative_alcohol_dehydrogenase, zinc-binding alcohol dehydrogenase family protein. Members of this model form a distinct subset of the larger family of oxidoreductases that includes zinc-binding alcohol dehydrogenases and NADPH:quinone reductases (pfam00107). The gene neighborhood of members of this family is not conserved and it appears that no members are characterized. The sequence of the family includes 6 invariant cysteine residues and one invariant histidine. It appears that no member is characterized. [Energy metabolism, Fermentation].	0
NZ_CP022223.1\|WP_094081127.1\|2987894_2990297_-\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	2.17112e-102
NZ_CP022223.1\|WP_009953029.1\|2984044_2986204_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|138873	PRK12320, PRK12320, hypothetical protein; Provisional.	0
NZ_CP022223.1\|WP_009956130.1\|3003085_3003466_+\|DUF4189-domain-containing-protein	gnl\|CDD\|372741	pfam13827, DUF4189, Domain of unknown function (DUF4189). This domain of unknown function contains six well-conserved cysteine residues.	1.08753e-08
NZ_CP022223.1\|WP_009956129.1\|3003672_3005058_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	4.679e-163
NZ_CP022223.1\|WP_009956131.1\|3001231_3002008_-\|molybdate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270256	cd13538, PBP2_ModA_like_1, Substrate binding domain of putative molybdate-binding protein;the type 2 periplasmic binding protein fold. This subfamily contains domains found in ModA proteins of putative ABC-type transporter. Molybdate transport system is comprised of a periplasmic binding protein, an integral membrane protein, and an energizer protein. These three proteins are coded by modA, modB, and modC genes, respectively. ModA proteins serve as initial receptors in the ABC transport of molybdate mostly in eubacteria and archaea. After binding molybdate with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ModA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.18062e-89
NZ_CP022223.1\|WP_009956134.1\|2999505_3000270_-\|molybdate-ABC-transporter-permease-subunit	gnl\|CDD\|130643	TIGR01581, Molybdenum_transport_system_permease_protein_modB., NifC-like ABC-type porter. This model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.	6.48464e-75
NZ_CP022223.1\|WP_094080969.1\|2990509_2991433_+\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	5.97304e-85

>NZ_CP022223.1|WP_008256923.1|2996678_2996978_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MDIMAATEFLARSSTLTSVGWIGYIIIGGIAGAIASKIIRGSGAGILMDIVIGIVGALVGGFILSFFVDTASGGYFFTFFTALLGSLLLLWIVGMVRRT
>NZ_CP022223.1|WP_094080970.1|2995603_2996632_-|zinc-binding-alcohol-dehydrogenase-family-protein
MASPVTTTAMRAWRVRRPGPMDTGPLEQVTTEVPRPGPSELLVAVRACGVCRTDLHVTEGDLPVHRERVTPGHEVVGEVVELGAEAGDEFRVGDRVGIAWLRHTCGVCKYCRRGAENLCPKSRYTGWDADGGYAEFATVPAAFAHPLPGGYSDSELAPLLCAGIIGYRSLLRADLPPGGRLGLYGFGGSAHITAQVALAQGAEVHVMTRGARARELALELGAASAQGAADPPPAPLDAAILFAPVGDLVLPALQALDRGGTLAIAGIHLSDIPALNYQRHLFQERQVRSVTSNTRADARAFLDFAGEHHIEVTTPEYPLGQADRALTDLSAGRIAGAAVLLV
>NZ_CP022223.1|WP_014942152.1|2994838_2995597_+|CPBP-family-intramembrane-metalloprotease
MHEAGTVDVHPVASQPSALHRFRIHLDIAVVVVVLVLTDLIAHFTTPWASVGTVPAAAVGLVILMRCRGLGWADLGLGREHWKPGLGYALAAVAVVASVIAVGVLLPATRPMFLNNRYATISGAMVASMVIIPLQTVIPEELAFRGVLHGALNRAWGFRGVALAGSLLFGLWHVATSFGLTSSNVGFTRLFGGGIVGMVAGVAGAVVATGAAGFVFSWLRRRSGSLIAPIALHWSLNGLGALAAAFVWHLST
>NZ_CP022223.1|WP_014382610.1|2992413_2994777_+|phosphoketolase-family-protein
MTHATALSDDELALIDKYWRAANYLSVGQIYLLDNPLLTEPLTIDHVKPRLLGHWGTTPGLNLVYAHLNRVIRHRDADVIYVTGPGHGGPGLVANAYLEGTYSEVYTGIEEDTEGLRKLFRQFSFPGGIPSHVAAQTPGSIHEGGELGYALVHAYGAALDNPYLVVACVVGDGEAETGPLAASWHSNKFLNPVTDGAVLPILALNGYKIANPAVLARIPHAELESLLRGYGYRPITVAGDDPADVHRQLAAALDDAFDDIAAIQSAARGGNGVERPVWPMIVLRTPKGWTGPKMVDGKKVEGTWRSHQVPLAATRDNPEHRAQLEEWLRSYGPGELFDENGRLRPELRALAPSGDRRMSANPHANGGLLLHDLDLPDFRDYAVAVERPAAVTHEATRVLGGFLRDVIARNKDRFRLMGPDETASNRLDAVYGSTDKVWLSEIEPDDEHLAPDGRVMEVLSEHLCQGWLEGYLLTGRHGLFNCYEAFVHIVDSMLNQHAKWLATSRELPWRRPIASLNYLLSSHVWRQDHNGASHQDPGFIDLVANKRPELTRVYLPPDGNTLLSVADHCLRSRDYINVIVAGKQPALAYLDMDEAVAHCTRGLGIWEWASTATDDPDVVLACAGDIPTLETLAAADILRSELPELAVRVVNVVDLMRLQPDTEHPHGLPDREFDALFTPDRPVIFAYHGYPWLIHRLTYSRTNHAHMHVRGFKERGTTTTPFDMVMLNDLDRFHLVMDVIDRVDGLASRAAMLRQRMVDARLAARMYTREHGEDDPKISGWTWGPSD
>NZ_CP022223.1|WP_014382609.1|2991534_2992383_+|SDR-family-oxidoreductase
MADTGSLGLKVRGKVIVITGGARGIGLATATALHNLGAKVAIGDVDGVRVKESGADLGLDVYGKLDVTDPHSFADFLDQVERRLGPIDVLINNAGIMPVGRIVDEPDAVTRRILDINVYGVILGSKLAAQRMVPRGTGHVINVASLAGELYIVGLATYCASKHAVVAFTDSARLEYRSAGVKFSAVLPTFVNTELTAGTNGAKGFRNAEPAEIADAIVKLVAHPKPRVRITKAAGAMVVSQKFWPRRIAEGLNRMLGGDHVFTDDVDVEKRQAYEARARGEE
>NZ_CP022223.1|WP_094080969.1|2990509_2991433_+|undecaprenyl-diphosphate-phosphatase
MTAHLSYVEAVVVGAFQGVTELFPVSSLGHAVLVPALVGGRWAQDLSVSAPHSPYLAFIVGLHVATAAALLLFFWRDWLRILSGFFSSLRYRRIQTPDERLAWLIVVGTIPVGLAGLALEQLFRTTLGKPMPAATFLLLNGIALYVGEVLRRRIAPAPAPGQPAPSDAELEHGDEASDQRLAQLPLPRGLVIGAAQILALFPGISRSGITIVAGLWRGLSHEDAARFSFLLATPIILAAGVYKIPELFGPLGAGIGGQVLAGSVVSFVCAYLAVRFLTRYFQTRTLTPFAIYCALAGAASLVWLAVR
>NZ_CP022223.1|WP_094081127.1|2987894_2990297_-|CoA-transferase
MVDGLLDAVRVLDLSSGVADVVTRLFADLGADVLKVEPPGGCLARDALPTLRGASIPFAVHNANKRSAVLDPFDDEDCARFLDLAADADIVVDTGADERGAMFGTSGEELAARYPHLVVLSITDFGATGPRSSWRATDPVLYAMCGALSRSGPTIGTPVLPPDGIASATAAVQAAWAALAAYYNRLRCGTGDYIDFSWFDAVVMALDPAFGAHGQAAAGVRRTGRWRGRPKNQDAYPIYPCRDGYVRLCVMAPRQWRGLRRWLGEPEDFQDPKYDVIGARFAVWPQISELLEKLFAGQSMKDLVAAGQAHGVPIAAVLTPARILGSDHFQAVGAITEAELVPGVRTAVPTGYFVVDGRRAGFRTPVPAAGHDEPYWRGNPSVVPSASGRLGDYPFAGLRILDLGIIVAGGELSRLFGDLGADVIKIESADYPDGLRQARVGEAMSESFAWTHRNNRGFGLDLRSAEGKKIFGRLVADADAVFANFKPGTLTALGFSYDELRALNPRIVLAESSAFGDTGPWSARLGYGPLVRATTGVTRLWTSDGPGEGADAARHAFYDATTVFPDHVVGRVTAIAALAALIHRDRTGNGAHVHISQAEVVVNQLDTLYVTQAALAAGIDRIRQDTSLHAVYPCAGDDEWCVISIRTDDEWRRAASVFDHPEWADDPRFATGEARLDNRDELVERVSAWTRTRTPLRAAELLQSAGVPAGPMNRPPDILEDPQLIARNVYSAMAHPLIENPLPAETGPAPYRHIPSARRAPAPQPGQDTVEICRNVLGMNTTDIQRLIDDRVLFGPAADA
>NZ_CP022223.1|WP_094080968.1|2986316_2987801_-|acetyl-CoA-acetyltransferase
MTADPRTPVLIGYGQVNHRDEIDPATRSVEPMDLMVAAVERAADAAVIEAVDSIRVVNILSAQYRDPGLLLGQRIGASDFTTLYSPVGGNVPQSLLNQACLDIQGGRAGVVLLAGAETWRTRRGLRAQGGKLVWTEQDRSVPMAEVSGDDVPMAGDAEIRISLDRPAYVYPLFEQALRVARGESIDDHLQRIGELWARFNAVAVDNPHAWIRTPSSADDIRRVGPRNRMISWPYTKLMNSNNMVDQGAALVLTSVEQARRLKIPAERWVYPHAGTDAHDTPSIAERHELHRSTAIRIAGARTLELAGLGIDDIDYVDLYSCFPSAVQVAAAELGLSVDDPARPLTVTGGLTFAGGPWSNYVMHSIATMAELLVANPGRRGLITANGGYLTKHSFGVYGTEPPAEFRWEDTQPEVDAEPTTDAVVEWEGVGTLEAWTTPYDREGRPEKAFLAVRTPDGSRALAVVTDADAVQASVREDLGGAKVAVAADGSATLR
>NZ_CP022223.1|WP_009953029.1|2984044_2986204_-|NAD-dependent-epimerase/dehydratase-family-protein
MHILVTDATGALGRLVAGQLIAAGHTVTGIAELPHPCLDRNVEFVCASLRDRVLRELTDEADAVIHLAPIDPTAPGSAGMDGLARVTDAAARAGSRLVFVSQAAGRPELYRPAEDLVSSSWGPTAVIRIAPPVGRQLDWMVCRTVATLLRSKVSAQPMRVLHLDDLMRFLVLAMDTDRTGVVDLASPDTVNMVTAWRVLRAADPRIRPHRVRSWAQLTPEFDVAAAQEDWMFSYGWHALDAVADTARGLVGRRLDTAGAINQGGQLALPVEVLPQSRRPAGDDVRTAAPEGLEGEFDDQIDSRFPVFSGAALAEALPGPLTPITLDVQLSGLRAASRVLGQALALGGVADAEWGSRAIAVFGHRAYVGVSVNMVAASQLPGWDQDAVARNALVDQPQVGDPLPFGEPAWTAGALGSVAKAVAAGRSVALLRHLRADTRAYCAAAEAEHLDAAQLALLPEAALEVRLRLLRDRIHQGWILNALWLIDTGVTAAALPRSQAGRSVPGISMITDSGLVAAETAELASALRADPPLRALAAEGNLASIRALSPKTAAIVDAVVARIGHRGPGEAELASKTFADDPTMLLTAAAGAAPPEPTPATLAERLTANARGSRELAHDTTMRFTHELRMTLRALGSLRVEADLIDAVDDMYYLTCNELVTMPGDARLRIKRRRTERERLQAQFPPDVIDGAWAPVPHSPDDSGAGTTAEDGSAEQLAQG
>NZ_CP022223.1|WP_009953028.1|2982838_2984071_+|FAD-dependent-oxidoreductase
MANSTSFVIIGGGLAAAKAVEALRDNDFDGHIIVFADEEHLPYERPPLSKEYLAGKKSLTDFTVQNSDWYRDHNVDLRLNTRVSTLDAAAHTVGLPDGTTVGYDKLLLATGSASRRPPIPGADSPGVHYLRTYEDAVALNDVLSEGASLAVVGAGWIGLEVAAGARQRGVNVTVVETARQPLLAALGETVGEVFATLHREHGVDLRLETQVAEITRADGSATGLRMRDGSTVAADAVLVAVGAKPNVELAEQAGLSLGDGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTRIRTEHWANALKQPAVAAAGMLGTPGEYAELPYFFTDQYDLGMEYVGHAPSFERVVFRGDVAGREFVAFWLDGDHRVLAGMNVNIWDVLDDVKALIRSKAAVDPDKLADPRSPLGELLG
>NZ_CP022223.1|WP_014380167.1|2998392_2999496_-|sulfate/molybdate-ABC-transporter-ATP-binding-protein
MSELQLRAVVADRQVDVEFSVSAGEVLAVLGPNGAGKSTVLHVIAGLLRPDHGTVRLGDRVLTDTAAGIDVPTHDRRVGLLLQDALLFPHMTVAANVAFGPHSRRASLRPARATQKATASRWLREVDAERLADRKPRQLSGGQAQRVAIARALAAEPDVLLLDEPLAGLDVAAAAAIRAVLREVVTRSGCAAILVTHDLLDVFTLADRVLVLESGKVAEIGPVPDVLTAPRSHFAARIAGVNLVNGTVDRDGSLVAVGGDRWYAAPPERGELVSPEQHAIAVFAPTVVAVYRDRPHGSPRNAVEVTVAEMDVRGSAVLVRGAQQPDGAPGLAAEITADAAAELRLAPGDRVWFSVKAHEVTLYPAAH
>NZ_CP022223.1|WP_009956134.1|2999505_3000270_-|molybdate-ABC-transporter-permease-subunit
MYLPAAVGTAFVGLPLLAVAVKVDWPHFWSLITSPSSLTALALSLRTATASTVLCVALGVPMALVLARSTARLVRLLRPLILLPLVLPPVVGGIALLYAFGRLGLLGQYLEAAGISIAFSTAAVVLAQTFVSLPFLVISLEGAARTAGADFEVVAATLGARPSAVWWRVTLPLLAPGVASGAVLAFARSLGEFGATLTFAGSRQGVTRTLPLEIYLQRVTDADAAVALSLLLVVVAALVVLGLGTRRLTGADAR
>NZ_CP022223.1|WP_014380169.1|3000291_3000543_+|hypothetical-protein
MRANTQPPADGHLDNFAEPAHPLLALHRNGVLGAPQWGRDPPTPAVSGGPMTGGQPVRENGFARPSPRVAGRSPSGRRCLDAI
>NZ_CP022223.1|WP_009956132.1|3000532_3001195_+|DUF2510-domain-containing-protein
MPSEQAPPPPKSAPGWYPDPAGVGHGLQRYFDGTNWTSEWAFATEPPRKGLSGKVALALSVLTVLVLLVIVGKSWGFERNDSQLPSSAPSTPTEAAPSTPAGPKKPDGVTFTTTQSPDGEIVDARFAIRDNYTELLIKDGARLDTIDILRYARATYPDASAVNVQGTFPMTDPYGNTSTQVAIDLTYSRETLNKINFDGVTKNSIWEIRDSGSILPAFQP
>NZ_CP022223.1|WP_009956131.1|3001231_3002008_-|molybdate-ABC-transporter-substrate-binding-protein
MRRIGFRTGLVSAMLVAGLVGCGSTPPPAQSPQASGKVMVFAAASLKPVFTRLGQQFTAENPGSGVEFEFAGSSELATQLTQGATADVFASADTAQMDTVSKAGLLSGAPRTFASNTLVIVTAPGNPKQIGSFADLAKPGLNVVTCQRPVPCGAATHRVEDSTGVRLNPVSEELSVTDALNKVTSGQADAALVYVTDAKTAGSRVATVTFPEAAGAVNVYPIAVLNKAAHPSQAQKFVDLVTSAAGQQILAQAGFARP
>NZ_CP022223.1|WP_008256934.1|3002195_3002873_+|SDR-family-oxidoreductase
MAVEVLVTGGDTELGRAVAEGFRDDGHKVTLVGARKSDLEIAAKELEVEAIVCDTTDPASLEEARPLFPHHLDTIVNVPAPTWEAGDPRTYSIADTANAWRKALDATVLSAVLTLQTVGDHLRSGGSIISVVPENPPAGSADAAIKATLANWTAGQASVFGTRGITVNAVASGRSAQAGYDGLTRTPAPVAAEVARLALFLTTSAARHITGQTLHVSHGALAQFA
>NZ_CP022223.1|WP_009956130.1|3003085_3003466_+|DUF4189-domain-containing-protein
MKKRAWAALAVGVALAPAPLAHADDNWIAMAISDSTGHISIADGAASQGAAEKAAMDTCRKSISDCRLLASGQGGCVALALNGAKSRYFGGWGPTREDAEAAALARAPGGMVQAGHDHCAGEGAPQ
>NZ_CP022223.1|WP_009956129.1|3003672_3005058_+|NAD(P)/FAD-dependent-oxidoreductase
MSPQPSNAAGPERRHQVVIIGSGFGGLNAAKKLKHANVDIKLIARTTHHLFQPLLYQVATGIVSEGDIAPPTRVVLRRQRNVQVLLGDVTHIDLAGKFVVSDLLGHTYETPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALEVRGRILSAFEQAERSRDPERRAKLLTFTVIGAGPTGVEMAGQIAELATYTLKGSFRHIDSTKARVILLDAAPAVLPPFGDKLGQRAADRLEKMGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASPLGRDLADQSTVELDRAGRVKVLPDLSVPGHPDVFVIGDLAAVEGVPGVAQGAIQGAKYVASTIKAELDGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGLFAWFAWLVLHLVYLVGFKTKISTLLSWTVTFLSTRRGQLTITEQQAFARTRLEQLAVLAAETKRPVARRAS
>NZ_CP022223.1|WP_009956128.1|3005108_3005531_-|PaaI-family-thioesterase
MPEPQETIIPPHFSAPFDREIGLQFTELSPDGARAQLEVTPKLLQPMGLVHGGVYCSMIESMASVAAYTWLATRGGGNVVGVNNNTDFLRSIGSGMLYGRVEPIHRGRSQQLWLVTITDDDDRVVARGQVRLQNLELREG
>NZ_CP022223.1|WP_014380173.1|3005495_3005711_+|hypothetical-protein
MRRDDRFLRLWHVPVSTPSRAGRLRRQHNSPDTPPKTAEPRAQGTGLADRVRPGVTAALRTLTRSVIARLE

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Crispr_ID: NZ_CP022223_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_4

3784069-3784177

Orphan

Consensus_repeat	Method
GGGTTGCCGCTACTCGCCTCGGTGGGGTTGCCCTTACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_4

>merge|NZ_CP022223|4|3784069-3784177|CRISPRCasFinder
GGGTTGCCCTTACTCGCCGTGGTGGGTTGCCGCTACTCGCCTCGGTGGGGTTGCCCTTACTAGGCGTGGTGGGGTTGCCGCTACTCGCCGTGGTGGGGTTGCCGTTACT

>NZ_CP022223|4|4|3784069-3784177|CRISPRCasFinder
GGGTTGCCCTTACTCGCCGTGGTGGGTTGCCGCTACTC	GCCTCGGTGGGGTTGCCCTTACTAGGCGTGGTG
GGGTTGCCGCTACTCGCCGTGGTGGGGTTGCCGTTACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_089151916.1\|3781445_3782387_+\|heme-A-synthase	unknown	unknown	gnl\|CDD\|224528
NZ_CP022223.1\|WP_008258105.1\|3784355_3785282_-\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP022223.1\|WP_008258094.1\|3773666_3774440_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP022223.1\|WP_065507568.1\|3792173_3792572_+\|ATPase	unknown	unknown	unknown
NZ_CP022223.1\|WP_089151913.1\|3777068_3777881_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP022223.1\|WP_089151912.1\|3774439_3775624_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_CP022223.1\|WP_020822943.1\|3785537_3787637_+\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP022223.1\|WP_042912365.1\|3787653_3788775_+\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NZ_CP022223.1\|WP_089151919.1\|3792584_3793514_+\|histone-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|212541
NZ_CP022223.1\|WP_008258116.1\|3790464_3791376_+\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	unknown	unknown	gnl\|CDD\|213538
NZ_CP022223.1\|WP_009951912.1\|3793528_3794518_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381310
NZ_CP022223.1\|WP_008258096.1\|3775623_3777072_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP022223.1\|WP_089151915.1\|3780594_3781371_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NZ_CP022223.1\|WP_065502924.1\|3782336_3782987_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_094081023.1\|3794648_3797465_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NZ_CP022223.1\|WP_089152445.1\|3779689_3780598_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP022223.1\|WP_089151914.1\|3777938_3779642_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274589
NZ_CP022223.1\|WP_065502922.1\|3783006_3783981_+\|quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176189
NZ_CP022223.1\|WP_089151918.1\|3791372_3792128_+\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|273494
NZ_CP022223.1\|WP_089151917.1\|3788771_3790316_+\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_089151916.1\|3781445_3782387_+\|heme-A-synthase	gnl\|CDD\|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	3.37461e-55
NZ_CP022223.1\|WP_008258105.1\|3784355_3785282_-\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	4.93544e-139
NZ_CP022223.1\|WP_008258094.1\|3773666_3774440_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	3.11159e-145
NZ_CP022223.1\|WP_089151913.1\|3777068_3777881_-\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	3.33473e-70
NZ_CP022223.1\|WP_089151912.1\|3774439_3775624_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	2.60852e-94
NZ_CP022223.1\|WP_020822943.1\|3785537_3787637_+\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP022223.1\|WP_042912365.1\|3787653_3788775_+\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NZ_CP022223.1\|WP_089151919.1\|3792584_3793514_+\|histone-deacetylase-family-protein	gnl\|CDD\|212541	cd11599, HDAC_classII_2, Histone deacetylases and histone-like deacetylases, classII. This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation.	8.4859e-165
NZ_CP022223.1\|WP_008258116.1\|3790464_3791376_+\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	gnl\|CDD\|213538	TIGR00534, Putative_OxPP_cycle_protein_OpcA, glucose-6-phosphate dehydrogenase assembly protein OpcA. The opcA gene is found immediately downstream of zwf, the glucose-6-phosphate dehydrogenase (G6PDH) gene, in a number of species, including Mycobacterium tuberculosis, Streptomyces coelicolor, Nostoc punctiforme, and Synechococcus sp. PCC 7942. In the latter, disruption of opcA was shown to block assembly of G6PDH into active oligomeric forms. [Protein fate, Protein folding and stabilization].	5.28636e-135
NZ_CP022223.1\|WP_009951912.1\|3793528_3794518_-\|aldo/keto-reductase	gnl\|CDD\|381310	cd19084, AKR_AKR11B1-like, AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR). Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.	6.13563e-142
NZ_CP022223.1\|WP_008258096.1\|3775623_3777072_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP022223.1\|WP_089151915.1\|3780594_3781371_+\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	8.65757e-57
NZ_CP022223.1\|WP_094081023.1\|3794648_3797465_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_CP022223.1\|WP_089152445.1\|3779689_3780598_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.52734e-89
NZ_CP022223.1\|WP_089151914.1\|3777938_3779642_+\|hypothetical-protein	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	3.66083e-62
NZ_CP022223.1\|WP_065502922.1\|3783006_3783981_+\|quinone-oxidoreductase	gnl\|CDD\|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.20594e-173
NZ_CP022223.1\|WP_089151918.1\|3791372_3792128_+\|6-phosphogluconolactonase	gnl\|CDD\|273494	TIGR01198, 6-phosphogluconolactonase_6PGL., 6-phosphogluconolactonase. This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway].	3.59174e-94
NZ_CP022223.1\|WP_089151917.1\|3788771_3790316_+\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0

>NZ_CP022223.1|WP_065502922.1|3783006_3783981_+|quinone-oxidoreductase
MHAIEVSETGGPEVLRYVDTPQPSPGPGEVLIEAEAIGVNYIDTYFRSGQYPRQLPFILGQETSGTVVDTGEGVEGFTAGDRVVTAAASGGYAEYATAPASFTASVPDGVPADVAASALLKGLTAHYLLKSVYPVQAGDTVLVHAGAGGVGLILTQWAHLLGARVITTVSTPEKARMSAKAGADEVLSYPDDADEFGERIRALTDGAGVAAVYDGVGATTFDASLASLAVRGTLALFGAASGPVPPFDPQRLNAAGSVFLTRPSLAHFVRTGQEFSWRAEELFSVIARGDITVEVGGRYPLADAARAHEDLQGRKTTGSIVLVP
>NZ_CP022223.1|WP_065502924.1|3782336_3782987_-|hypothetical-protein
MKLARPDVFHPRIVLAGPGDDPDDAGLVPALRRRGLHARWLSWDDPGTAQADLVILRAAPAGPGRRDEFLAWTRRVRHLLNPPDAIAWNFAERYLRDLADDGIPTDPGATARSTLIFLGGERSHAWPGEPEFESWDLAYAALAAAAERAGVGARELLYARADVAGDRLVKLDFVAPQLGWRHVDAATRELAQRRFAVAVESGCERLGLGPFSHRRP
>NZ_CP022223.1|WP_089151916.1|3781445_3782387_+|heme-A-synthase
MLLRLVDLLPNPSLGVQRLIAAAVILTQGGIAITGAIVRVTASGLGCPTWPQCFPGSFVPVAHAEVPRIHQAVEFGNRMVTFAVVITAALAVLAVTRARRRREVLVYAWLMPVSTVVQAVIGGITVRTGLLWWTVAIHLLTSMTMVWLAVLLYVKIGEPDDGAVRVLIPAPLRALTALSGVNLAAVLITGTLVTAAGPHAGDRSATRTVPRLKVEVATLVHVHSSLLVAYLALVVGLGFGLLAVRATRPVLWRLGVLLVLLCAQAAVGTAQYYTGVPAALVALHVAGAAAATAATAALWASMRERAEPEPLAA
>NZ_CP022223.1|WP_089151915.1|3780594_3781371_+|ABC-transporter-permease
MSESPFPAGTFAPDPRPSTVPKMLAAQFGLELKLLLRNGEQLLLTMFIPITLLVGLTLLPLGSFGQHRAATFTPVIMALAVISTAFTGQAIAVAFDRRYGALKRLGATPLPVWGIIAGKSLAVVTVVFLQAILLGAIGFALGWRPALIALALGAAVIALGTVVFAALGLLLGGTLRAEIVLAVANLMWFVFAGLGALTVETDIIPTGVKWAARLTPSGALTEALSQAMTMSVDWFGVIVLAAWGALGALSALRWFRFT
>NZ_CP022223.1|WP_089152445.1|3779689_3780598_+|ABC-transporter-ATP-binding-protein
MRLRGVSKHYGSTTAVSDLDLEVHAAEVLALLGPNGAGKTTTVEMCEGFVRPDAGTIEVLGLDPIADNARLRARIGVMLQGGGGYPAARAGEMLDLVAAYAADPLDPAWLLDILGLTDAARTTYRRLSGGQQQRLALACALVGRPELVFLDEPTAGMDAHARLLVWELIDALRRDGVTVLLTTHQLKEAEELADRIVIIDNGATVASGTPTELMRSGAKDQLRFSAPPRLDLSLLSAALPEDYKATEVTPGEYLVEGPVDPQVLATVTAWCARIDVLATDMRVEQRSLEDVFLDLTGRKLRP
>NZ_CP022223.1|WP_089151914.1|3777938_3779642_+|hypothetical-protein
MSARHHTLSSSIASLHGDEQAVGAPLNDTELTSLRRIRLFGASGTMLMAIGALGAGARPVVQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMALAWLMLGRFALGNRRMSRGDLDRTLLLWVLPLLIAPPMYSKDVYSYLAQSQISLEGLDPYRVGPASGLGLSHIFTLSVPTLWRETPAPYGPLFLWMGRGISAITGENIVAAVLCHRLVELLGVALIVWATPRLARRCGVAEVSALWLGAANPLLIMHLVAGVHNEALMLGLMLAGAEFALRGVDTPRLLPRSLKPGPDWEPLGMLVAGAVLITLSSQVKLPSLLALGFVTMALAYRRGGNLRALLLTGGGMAALSLAVMAVVGWASGLGFGWIYTLGTANVVRSWMSPPTLLALGTGQVGILLGLGDHTTAVLGLTRAIGVLIITVMVAWLLLAVFRGRLHPIGGLGVALGICVLLFPVVQPWYLLWAIIPLACWATRTGFRVAAIVISLVVGIFGPTANGDRFALFQIVDATLASTVIVVLLIALTYTRLPWRPPPAQARETDPRPAADPSSPAQPAPTPRPAPTHDAYADST
>NZ_CP022223.1|WP_089151913.1|3777068_3777881_-|transcriptional-regulator
MLDRSSELRHTGVVKIRTSPDGVAAPDVGAASSDRHTRRAIVRLLLESGTITAGEIGDRLGLAAAGVRRHLDALIEAGDAEATAPAAWQQAGRGRPAKRYRLTARGRAKLDHAYDDLAAAAMRQLREIGGEEAVQAFARQRIDAILTEVTAADSAADDDVEAAAERIATALTKAGYVASTTQVGGPIHGVQICQHHCPVSHVAEEFPELCEAEQQAMAEVLGTHVQRLATIVNGDCACTTHVPLTQSKASSTAPSPRHMTDTTSIKGASR
>NZ_CP022223.1|WP_008258096.1|3775623_3777072_-|Fe-S-cluster-assembly-protein-SufB
MTLTPEASKTATAPLTQEEAIASLGRYGYGWADSDVAGASAQRGLSEAVVRDISEKKSEPEWMLQARLKALRIFERKPMPTWGSNLEGIDFENIKYFVRSTEKQAATWDDLPEDIRNTYDRLGIPEAEKQRLVGGVAAQYESEVVYHQIREDLEAQGVIFVDTDTGLREHPEIFQEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCTAPIYKSDSLHSAVVEIIVKPNARVRYTTIQNWSSNVYNLVTKRARAEAGATMEWVDGNIGSKVTMKYPAVWMTGEYAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRASYRGLVQVNKGAHGSRSSVKCDALLVDTISRSDTYPYVDIREDDVTMGHEATVSKVSEDQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
>NZ_CP022223.1|WP_089151912.1|3774439_3775624_-|Fe-S-cluster-assembly-protein-SufD
MTNLTEAVEGSSLTALNKGELFSSFDVDAFEVPHGRDEIWRFTPLRRLRGLHDGSAHATGKAQITVTEQPGVRTEVVRRGDERLGQGGVPTDRVAAQAFSSFNSATVVTVARDTEVAKPIEIVVDGPGEGGVAYGHLQIRVEELARAIVVVDLRGSGTYADNVEIIVSDSAALGVIWIADWADDMVNVSAHHARLGKDSVLGHVNVTLGGDLVRTSTTVRFTAAGGDAQLLGTYFADDGQHIESRLLVDHAHPNCRSDVLYKGALQADPESDRPDAHAVWVGDVLIRAEATGTDTFETNRNLILTDGARADSVPNLEIETGEIVGAGHASATGRFDDEQVFYLRARGIPEDQARRLIVRGFFAEIIQKIAVPAVRERLTEAIEHELELTEGNKN
>NZ_CP022223.1|WP_008258094.1|3773666_3774440_-|Fe-S-cluster-assembly-ATPase-SufC
MTTLEIKDLHVSVARTNEADAIGILKGVDLTVKSGETHALMGPNGSGKSTLSYAIAGHPKYEVTSGSITLDGQDVLAMSVDERARAGLFLAMQYPIEVTGVSMSNFLRSAATAVRGEAPKLRHWVKEVKAAMDDLGIDPAFSERSVNEGFSGGEKKRHEILQLSLLKPKIAILDETDSGLDVDALRVVSEGVNRYAEAEHGGVLLITHYTRILRYIQPQFVHVFVGGRIVEAGGPELADQLEEHGYERFVQAASAKA
>NZ_CP022223.1|WP_008258105.1|3784355_3785282_-|protoheme-IX-farnesyltransferase
MSVRGRAAPSRLPSRVRGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTLIGGMLAAGGANTLNCVADADIDKVMKRTARRPLARAAVPTRNALVLGLVLTVGSFFWLWWTTNLLSGLLALATIAFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTNTIGWPALVMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQILIYTWLTVLSTLALALATGWLYAAVAVVAGVWFLAMAHQLYAGVRVGEPVKPLRLFLQSNNYLAVVFCALAIDSAIGLPHLF
>NZ_CP022223.1|WP_020822943.1|3785537_3787637_+|transketolase
MTTLEEISTLTQPHLPDDWSELDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDAAPGTSPFDHFIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEDDTNIALCEDTAARYEAYGWHVQRVEGGENVVGIQEAIAAAQAVTDRPSFIELRTIIGYPAPKLMNTGKAHGAALGDEEVAAVKQILGFDPDKNFEVRDEVIAHTRKLVDRGKEAHEKWQADFDAWVQREPDRKALLDRLTAEELPDGWDADIPHWEPGSKELATRAASGKVLSALGPKLPELWGGSADLAGSNNTTMDGVKSFGPPSISTKDYTADWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLASLMDIDTIYVWTHDSIGLGEDGPTHQPIEHLAALRAIPKLSVVRPADANETAHAWRTILARGNGSGPVGLILTRQGVPVLEGTSAEGVARGGYILGSDGEEAGQDPDVVLIATGSEVQLAVKAQKLLADKDIVARVVSMPCVEWFESQPDDYRDSVLPPSVSARVAVEAGVAQSWHKLVGDTGKIVSIEHYGESADYKTLFREFGFTAEAVAAAAEQVVDN
>NZ_CP022223.1|WP_042912365.1|3787653_3788775_+|transaldolase
MTAQNPNLAALSAAGVSVWLDDLSRERLRSGNLQELIDTKSVVGVTTNPSIFQKAFAEGDAYDSQIAELAERGADVDATIRTVTTDDVRNACDVLTREWENSDGVDGRVSIEVDPRLAGDTDKTIAQAVELWKIVDRPNLFIKIPATEAGIPAITAVLAEGISVNVTLIFSVERYRAVMDAYLAGMEKAREGGHDLSKIHSVASFFVSRVDTEVDKRLEKIGSEDAKALLGQAGVANARLAYAAYQEVFEGGERYQALKAHGARVQRPLWASTGVKNPDYSDTLYVTELVAPNTVNTMPEKTIDAVADHGVIKGDTVTGTAADAEAVFDKLDQIGIDLSDVFVVLEDEGVEKFVDSWTELLEETQKQLGSASK
>NZ_CP022223.1|WP_089151917.1|3788771_3790316_+|glucose-6-phosphate-dehydrogenase
MSPARTAQQWHNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAIYDLANRGLLPPSFSLVGFARRDWSTQDFGKVVYEAVKEHCRTPFREENWERLAEGFRFVPGAFDDDEAFARLAETLDKLDAERGTGGNHAFYLAIPPKSFPVVCDQLHKSGLARPPKDGWARVVIEKPFGHNLESAQALNQSVNAVFPEESVFRIDHYLGKETVRNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFSPRALQAEKIKVLSATQLAEPLDETTSRGQYSAGWQGGEKVLGLLDEEGFAKDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALIFKRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEESPEAYEQLILDVLLGEPSLFPVNEEVELAWQILDPVLDNWAAGGKPEPYEAGTWGPDSAFEMLHRTGREWRRP
>NZ_CP022223.1|WP_008258116.1|3790464_3791376_+|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA
MIIDMPDATTTAVNKKLDELRERVGAVAMGRVLTLIIAPDSEEILEESLQAANDASHEHPSRIIVTMRGNPYADKPRLDAQLRAGGDTGASEVVVLRLSGALSGHAASVVTPFLLPDIPVVAWWPDVAPAVPAQDPLGRLAIRRITDATNGVDPLAAIKSRLPGYTAGDTDLAWARITYWRALLTSAVDLTPHEPIESALVSGLATEPALDVLAGWLASRIDGPVRRAVGELKIELTRSSETIVLSRPQEGRTATLSRTSRPDALLPLARRETGECLAEDLRRLDPDEIYQTALEGIEKVQYV
>NZ_CP022223.1|WP_089151918.1|3791372_3792128_+|6-phosphogluconolactonase
MSTSIEIFPDSQALVDAAATRLTDTIGNAVAARGRALVVLTGGGNGIGLLRSLVDRPIEWSKVHLFWGDERYVPEDDDERNDKQARAALLDHVDIPSSQVHPMPASDGEFGGDLAAAALAYEQLLAANAAPGQPVPNFDVHLLGMGPEGHINSLFPDTPAVLETTRMVVPVEDSPKPPPQRITLTLPAIARSREVWLMVSGAGKADAAAAAIGGAAPVSVPAAGAIGQQTTLWLLDEDAASKLPSDPSGVA
>NZ_CP022223.1|WP_065507568.1|3792173_3792572_+|ATPase
MAVMADRTVRGGQERSRIKTLTQAALNADKTVEQVEDVLDGLSNTMKELSSSLSALNATVERLEAGLDHLDGTMASLDDLAKRLIVLVEPVEAIVARIDEMVKVGETMMSPLSITEHAVRGLLDRLRNRTAE
>NZ_CP022223.1|WP_089151919.1|3792584_3793514_+|histone-deacetylase-family-protein
MATLLLHHSAFAAHRTAPGHPERPDRYRAVEAALRQPRFDALVRETAEPAELAAARYVHSNRYVDALEAARPEHGYVYLDGGDTMMEPSTWETALRGVGATLRAVDRVLAGDVQNAFVACRPPGHHAESERAMGFCLFNNISIGARHAQRKHGLMRVAIVDFDVHHGNGTQQIFYSDPSVLYASTHQMPLFPGTGAARETGVGNIFNAPLAPGDGGAELRAAFADRILPALHAFSPELIIVSAGFDAHERDPLGSLTMTTDDFAWATRELMKSAETLCDGRLVAVLEGGYDLQALADSVTAHVGELVKG
>NZ_CP022223.1|WP_009951912.1|3793528_3794518_-|aldo/keto-reductase
MKSITFGKTGLEVSRLAFGTWAFSSDWGQADEDAAITMIQRARDLGINFFDTAQQYGFGESERILGKALRDDFARARDELVIATKGGLRKTDTGLVRDASREYLRSGVESSLRALGVDYIDLYLVHWPDPTTPAAETGEALAELVSEGKIRHVGVSNYDTTQIEELSATLPVEAVQPPYHLFRRDIESDLLPYCHAHDIGVMVYGPLAHGLLTGTMKPDTSFADGDWRGKSPIFTGEDYLRNLKVVDDLSHLAIDLGVTTSQLAIAWTLAQPGVHTAIMGAQHVTYLQDSAGAADVTLTDADLAAIEDIMKSATPVGGPAPEMHEKKAS
>NZ_CP022223.1|WP_094081023.1|3794648_3797465_-|phosphoenolpyruvate-carboxylase
MADASEASEDTLEPIGAVQRTPVGREATEPMRADIRLLGAILGDTVREQNGREVFELVERARVESFRVRRSEIDRAELARMFYRIDIHRAIPVIRAFSHFALLANVAEDIHRERRRAVHVAAGEPPPDSTLAATYAKLDEAQLDSDTVADALKGAVVAPVITAHPTETRRRTVFVTQHRITELMRLHAEGHAETDDGRNIELELRRQVLTLWQTALIRLSRLQITDEIEVGLRYYAAAFFKVIPQVNAEVRDALRARWPDADLFDEPMLQPGSWIGGDRDGNPNVTADVVRQATGSAAFTALAHYLAELTALEQELSMSARLVSVTPALTELAGGCAEKARADEPYRRAVRVVRARLSATSAAILDRTPQQVLDLGLPPYETPAELGADLDTIDESLRGHGSALLADDRLALLREGVRVFGFHLCGLDMRQNSDAHEEVIGELLAWAGVHPDYRSLPEDERVELLAAELGTRRPLVADDAQLSDLARGELGVVRAAAHAIKRYGPSAVPNYVISMCRSVSDVLEAAILLKEAGLIDASGPEPYCPVGISPLFETIDDLHNGATILHAMLELPIYRALVAARGETQEVMLGYSDSNKDGGYLASSWAVYRAELALVEVARKTGIRLRLFHGRGGTVGRGGGPSYEAILAQPPGAVNGSLRLTEQGEVIAAKYAEPQAAQRNLESLLAATLESTLLDVEGLGDAAEPAYAVLDEVAVLAQRAYAELVHDTPGFVDYFMASTPVSEIGSLNIGSRPTSRKPTESISDLRAIPWVLAWSQSRVMLPGWYGTGSAFEQWIAAGPQSEAERVSILHDLYQRWPFFRSVLSNLAQVLAKSDLGLAARYAELVGDEELRRRVFGKIVDEHGRTIAMHKLITGQDNLLADNPALARSVFNRFPYLEPLNHLQVELLRRYRSGDDDELVQRGILLTMNGLASALRNSG

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Crispr_ID: NZ_CP022223_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_5

3790355-3790470

Orphan

Consensus_repeat	Method
GCGGGGGACGCAGCGATGAGGAGGAGTGGCGCAATTGATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_5

>merge|NZ_CP022223|5|3790355-3790470|CRISPRCasFinder
GCGGGGGACGCAGCGATGAGGAGGAGTGGCGCAATTGATACGCGCCACGACGATGCAGCGGGGGTACCTCCCGCTGGCGGGGGACGCAGCGATGAGGAGGAGTGGCGCAATTGATA

>NZ_CP022223|5|5|3790355-3790470|CRISPRCasFinder
GCGGGGGACGCAGCGATGAGGAGGAGTGGCGCAATTGATA	CGCGCCACGACGATGCAGCGGGGGTACCTCCCGCTG
GCGGGGGACGCAGCGATGAGGAGGAGTGGCGCAATTGATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_089151916.1\|3781445_3782387_+\|heme-A-synthase	unknown	unknown	gnl\|CDD\|224528
NZ_CP022223.1\|WP_008258105.1\|3784355_3785282_-\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP022223.1\|WP_008258127.1\|3797767_3798553_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NZ_CP022223.1\|WP_094081023.1\|3794648_3797465_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NZ_CP022223.1\|WP_065507568.1\|3792173_3792572_+\|ATPase	unknown	unknown	unknown
NZ_CP022223.1\|WP_003876059.1\|3797503_3797737_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|235881
NZ_CP022223.1\|WP_042912365.1\|3787653_3788775_+\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NZ_CP022223.1\|WP_020822943.1\|3785537_3787637_+\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP022223.1\|WP_009951912.1\|3793528_3794518_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381310
NZ_CP022223.1\|WP_089151919.1\|3792584_3793514_+\|histone-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|212541
NZ_CP022223.1\|WP_065500588.1\|3799788_3800808_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NZ_CP022223.1\|WP_042912379.1\|3800935_3802366_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP022223.1\|WP_089151922.1\|3798549_3799785_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP022223.1\|WP_089151915.1\|3780594_3781371_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NZ_CP022223.1\|WP_065502924.1\|3782336_3782987_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_089152445.1\|3779689_3780598_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP022223.1\|WP_089151914.1\|3777938_3779642_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274589
NZ_CP022223.1\|WP_065502922.1\|3783006_3783981_+\|quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176189
NZ_CP022223.1\|WP_089151918.1\|3791372_3792128_+\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|273494
NZ_CP022223.1\|WP_089151917.1\|3788771_3790316_+\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_089151916.1\|3781445_3782387_+\|heme-A-synthase	gnl\|CDD\|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	3.37461e-55
NZ_CP022223.1\|WP_008258105.1\|3784355_3785282_-\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	4.93544e-139
NZ_CP022223.1\|WP_008258127.1\|3797767_3798553_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	1.23986e-140
NZ_CP022223.1\|WP_094081023.1\|3794648_3797465_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_CP022223.1\|WP_089151922.1\|3798549_3799785_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP022223.1\|WP_003876059.1\|3797503_3797737_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|235881	PRK06870, secG, preprotein translocase subunit SecG; Reviewed.	6.06782e-13
NZ_CP022223.1\|WP_042912365.1\|3787653_3788775_+\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NZ_CP022223.1\|WP_020822943.1\|3785537_3787637_+\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP022223.1\|WP_009951912.1\|3793528_3794518_-\|aldo/keto-reductase	gnl\|CDD\|381310	cd19084, AKR_AKR11B1-like, AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR). Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.	6.13563e-142
NZ_CP022223.1\|WP_089151919.1\|3792584_3793514_+\|histone-deacetylase-family-protein	gnl\|CDD\|212541	cd11599, HDAC_classII_2, Histone deacetylases and histone-like deacetylases, classII. This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation.	8.4859e-165
NZ_CP022223.1\|WP_065500588.1\|3799788_3800808_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
NZ_CP022223.1\|WP_042912379.1\|3800935_3802366_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.44561e-90
NZ_CP022223.1\|WP_089151915.1\|3780594_3781371_+\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	8.65757e-57
NZ_CP022223.1\|WP_089152445.1\|3779689_3780598_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.52734e-89
NZ_CP022223.1\|WP_089151914.1\|3777938_3779642_+\|hypothetical-protein	gnl\|CDD\|274589	TIGR03459, crt_membr, carotene biosynthesis associated membrane protein. This model represents a family of hydrophobic and presumed membrane proteins found in the Actinobacteria. The genes encoding these proteins are syntenically associated with (found proximal to) genes of carotene biosynthesis ususally including phytoene synthase (crtB), phytoene dehydrogenase (crtI) and geranylgeranyl pyrophosphate synthase (ispA).	3.66083e-62
NZ_CP022223.1\|WP_065502922.1\|3783006_3783981_+\|quinone-oxidoreductase	gnl\|CDD\|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.20594e-173
NZ_CP022223.1\|WP_089151918.1\|3791372_3792128_+\|6-phosphogluconolactonase	gnl\|CDD\|273494	TIGR01198, 6-phosphogluconolactonase_6PGL., 6-phosphogluconolactonase. This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway].	3.59174e-94
NZ_CP022223.1\|WP_089151917.1\|3788771_3790316_+\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0

>NZ_CP022223.1|WP_089151917.1|3788771_3790316_+|glucose-6-phosphate-dehydrogenase
MSPARTAQQWHNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAIYDLANRGLLPPSFSLVGFARRDWSTQDFGKVVYEAVKEHCRTPFREENWERLAEGFRFVPGAFDDDEAFARLAETLDKLDAERGTGGNHAFYLAIPPKSFPVVCDQLHKSGLARPPKDGWARVVIEKPFGHNLESAQALNQSVNAVFPEESVFRIDHYLGKETVRNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFSPRALQAEKIKVLSATQLAEPLDETTSRGQYSAGWQGGEKVLGLLDEEGFAKDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALIFKRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEESPEAYEQLILDVLLGEPSLFPVNEEVELAWQILDPVLDNWAAGGKPEPYEAGTWGPDSAFEMLHRTGREWRRP
>NZ_CP022223.1|WP_042912365.1|3787653_3788775_+|transaldolase
MTAQNPNLAALSAAGVSVWLDDLSRERLRSGNLQELIDTKSVVGVTTNPSIFQKAFAEGDAYDSQIAELAERGADVDATIRTVTTDDVRNACDVLTREWENSDGVDGRVSIEVDPRLAGDTDKTIAQAVELWKIVDRPNLFIKIPATEAGIPAITAVLAEGISVNVTLIFSVERYRAVMDAYLAGMEKAREGGHDLSKIHSVASFFVSRVDTEVDKRLEKIGSEDAKALLGQAGVANARLAYAAYQEVFEGGERYQALKAHGARVQRPLWASTGVKNPDYSDTLYVTELVAPNTVNTMPEKTIDAVADHGVIKGDTVTGTAADAEAVFDKLDQIGIDLSDVFVVLEDEGVEKFVDSWTELLEETQKQLGSASK
>NZ_CP022223.1|WP_020822943.1|3785537_3787637_+|transketolase
MTTLEEISTLTQPHLPDDWSELDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDAAPGTSPFDHFIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEDDTNIALCEDTAARYEAYGWHVQRVEGGENVVGIQEAIAAAQAVTDRPSFIELRTIIGYPAPKLMNTGKAHGAALGDEEVAAVKQILGFDPDKNFEVRDEVIAHTRKLVDRGKEAHEKWQADFDAWVQREPDRKALLDRLTAEELPDGWDADIPHWEPGSKELATRAASGKVLSALGPKLPELWGGSADLAGSNNTTMDGVKSFGPPSISTKDYTADWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLASLMDIDTIYVWTHDSIGLGEDGPTHQPIEHLAALRAIPKLSVVRPADANETAHAWRTILARGNGSGPVGLILTRQGVPVLEGTSAEGVARGGYILGSDGEEAGQDPDVVLIATGSEVQLAVKAQKLLADKDIVARVVSMPCVEWFESQPDDYRDSVLPPSVSARVAVEAGVAQSWHKLVGDTGKIVSIEHYGESADYKTLFREFGFTAEAVAAAAEQVVDN
>NZ_CP022223.1|WP_008258105.1|3784355_3785282_-|protoheme-IX-farnesyltransferase
MSVRGRAAPSRLPSRVRGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTLIGGMLAAGGANTLNCVADADIDKVMKRTARRPLARAAVPTRNALVLGLVLTVGSFFWLWWTTNLLSGLLALATIAFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTNTIGWPALVMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQILIYTWLTVLSTLALALATGWLYAAVAVVAGVWFLAMAHQLYAGVRVGEPVKPLRLFLQSNNYLAVVFCALAIDSAIGLPHLF
>NZ_CP022223.1|WP_065502922.1|3783006_3783981_+|quinone-oxidoreductase
MHAIEVSETGGPEVLRYVDTPQPSPGPGEVLIEAEAIGVNYIDTYFRSGQYPRQLPFILGQETSGTVVDTGEGVEGFTAGDRVVTAAASGGYAEYATAPASFTASVPDGVPADVAASALLKGLTAHYLLKSVYPVQAGDTVLVHAGAGGVGLILTQWAHLLGARVITTVSTPEKARMSAKAGADEVLSYPDDADEFGERIRALTDGAGVAAVYDGVGATTFDASLASLAVRGTLALFGAASGPVPPFDPQRLNAAGSVFLTRPSLAHFVRTGQEFSWRAEELFSVIARGDITVEVGGRYPLADAARAHEDLQGRKTTGSIVLVP
>NZ_CP022223.1|WP_065502924.1|3782336_3782987_-|hypothetical-protein
MKLARPDVFHPRIVLAGPGDDPDDAGLVPALRRRGLHARWLSWDDPGTAQADLVILRAAPAGPGRRDEFLAWTRRVRHLLNPPDAIAWNFAERYLRDLADDGIPTDPGATARSTLIFLGGERSHAWPGEPEFESWDLAYAALAAAAERAGVGARELLYARADVAGDRLVKLDFVAPQLGWRHVDAATRELAQRRFAVAVESGCERLGLGPFSHRRP
>NZ_CP022223.1|WP_089151916.1|3781445_3782387_+|heme-A-synthase
MLLRLVDLLPNPSLGVQRLIAAAVILTQGGIAITGAIVRVTASGLGCPTWPQCFPGSFVPVAHAEVPRIHQAVEFGNRMVTFAVVITAALAVLAVTRARRRREVLVYAWLMPVSTVVQAVIGGITVRTGLLWWTVAIHLLTSMTMVWLAVLLYVKIGEPDDGAVRVLIPAPLRALTALSGVNLAAVLITGTLVTAAGPHAGDRSATRTVPRLKVEVATLVHVHSSLLVAYLALVVGLGFGLLAVRATRPVLWRLGVLLVLLCAQAAVGTAQYYTGVPAALVALHVAGAAAATAATAALWASMRERAEPEPLAA
>NZ_CP022223.1|WP_089151915.1|3780594_3781371_+|ABC-transporter-permease
MSESPFPAGTFAPDPRPSTVPKMLAAQFGLELKLLLRNGEQLLLTMFIPITLLVGLTLLPLGSFGQHRAATFTPVIMALAVISTAFTGQAIAVAFDRRYGALKRLGATPLPVWGIIAGKSLAVVTVVFLQAILLGAIGFALGWRPALIALALGAAVIALGTVVFAALGLLLGGTLRAEIVLAVANLMWFVFAGLGALTVETDIIPTGVKWAARLTPSGALTEALSQAMTMSVDWFGVIVLAAWGALGALSALRWFRFT
>NZ_CP022223.1|WP_089152445.1|3779689_3780598_+|ABC-transporter-ATP-binding-protein
MRLRGVSKHYGSTTAVSDLDLEVHAAEVLALLGPNGAGKTTTVEMCEGFVRPDAGTIEVLGLDPIADNARLRARIGVMLQGGGGYPAARAGEMLDLVAAYAADPLDPAWLLDILGLTDAARTTYRRLSGGQQQRLALACALVGRPELVFLDEPTAGMDAHARLLVWELIDALRRDGVTVLLTTHQLKEAEELADRIVIIDNGATVASGTPTELMRSGAKDQLRFSAPPRLDLSLLSAALPEDYKATEVTPGEYLVEGPVDPQVLATVTAWCARIDVLATDMRVEQRSLEDVFLDLTGRKLRP
>NZ_CP022223.1|WP_089151914.1|3777938_3779642_+|hypothetical-protein
MSARHHTLSSSIASLHGDEQAVGAPLNDTELTSLRRIRLFGASGTMLMAIGALGAGARPVVQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMALAWLMLGRFALGNRRMSRGDLDRTLLLWVLPLLIAPPMYSKDVYSYLAQSQISLEGLDPYRVGPASGLGLSHIFTLSVPTLWRETPAPYGPLFLWMGRGISAITGENIVAAVLCHRLVELLGVALIVWATPRLARRCGVAEVSALWLGAANPLLIMHLVAGVHNEALMLGLMLAGAEFALRGVDTPRLLPRSLKPGPDWEPLGMLVAGAVLITLSSQVKLPSLLALGFVTMALAYRRGGNLRALLLTGGGMAALSLAVMAVVGWASGLGFGWIYTLGTANVVRSWMSPPTLLALGTGQVGILLGLGDHTTAVLGLTRAIGVLIITVMVAWLLLAVFRGRLHPIGGLGVALGICVLLFPVVQPWYLLWAIIPLACWATRTGFRVAAIVISLVVGIFGPTANGDRFALFQIVDATLASTVIVVLLIALTYTRLPWRPPPAQARETDPRPAADPSSPAQPAPTPRPAPTHDAYADST
>NZ_CP022223.1|WP_089151918.1|3791372_3792128_+|6-phosphogluconolactonase
MSTSIEIFPDSQALVDAAATRLTDTIGNAVAARGRALVVLTGGGNGIGLLRSLVDRPIEWSKVHLFWGDERYVPEDDDERNDKQARAALLDHVDIPSSQVHPMPASDGEFGGDLAAAALAYEQLLAANAAPGQPVPNFDVHLLGMGPEGHINSLFPDTPAVLETTRMVVPVEDSPKPPPQRITLTLPAIARSREVWLMVSGAGKADAAAAAIGGAAPVSVPAAGAIGQQTTLWLLDEDAASKLPSDPSGVA
>NZ_CP022223.1|WP_065507568.1|3792173_3792572_+|ATPase
MAVMADRTVRGGQERSRIKTLTQAALNADKTVEQVEDVLDGLSNTMKELSSSLSALNATVERLEAGLDHLDGTMASLDDLAKRLIVLVEPVEAIVARIDEMVKVGETMMSPLSITEHAVRGLLDRLRNRTAE
>NZ_CP022223.1|WP_089151919.1|3792584_3793514_+|histone-deacetylase-family-protein
MATLLLHHSAFAAHRTAPGHPERPDRYRAVEAALRQPRFDALVRETAEPAELAAARYVHSNRYVDALEAARPEHGYVYLDGGDTMMEPSTWETALRGVGATLRAVDRVLAGDVQNAFVACRPPGHHAESERAMGFCLFNNISIGARHAQRKHGLMRVAIVDFDVHHGNGTQQIFYSDPSVLYASTHQMPLFPGTGAARETGVGNIFNAPLAPGDGGAELRAAFADRILPALHAFSPELIIVSAGFDAHERDPLGSLTMTTDDFAWATRELMKSAETLCDGRLVAVLEGGYDLQALADSVTAHVGELVKG
>NZ_CP022223.1|WP_009951912.1|3793528_3794518_-|aldo/keto-reductase
MKSITFGKTGLEVSRLAFGTWAFSSDWGQADEDAAITMIQRARDLGINFFDTAQQYGFGESERILGKALRDDFARARDELVIATKGGLRKTDTGLVRDASREYLRSGVESSLRALGVDYIDLYLVHWPDPTTPAAETGEALAELVSEGKIRHVGVSNYDTTQIEELSATLPVEAVQPPYHLFRRDIESDLLPYCHAHDIGVMVYGPLAHGLLTGTMKPDTSFADGDWRGKSPIFTGEDYLRNLKVVDDLSHLAIDLGVTTSQLAIAWTLAQPGVHTAIMGAQHVTYLQDSAGAADVTLTDADLAAIEDIMKSATPVGGPAPEMHEKKAS
>NZ_CP022223.1|WP_094081023.1|3794648_3797465_-|phosphoenolpyruvate-carboxylase
MADASEASEDTLEPIGAVQRTPVGREATEPMRADIRLLGAILGDTVREQNGREVFELVERARVESFRVRRSEIDRAELARMFYRIDIHRAIPVIRAFSHFALLANVAEDIHRERRRAVHVAAGEPPPDSTLAATYAKLDEAQLDSDTVADALKGAVVAPVITAHPTETRRRTVFVTQHRITELMRLHAEGHAETDDGRNIELELRRQVLTLWQTALIRLSRLQITDEIEVGLRYYAAAFFKVIPQVNAEVRDALRARWPDADLFDEPMLQPGSWIGGDRDGNPNVTADVVRQATGSAAFTALAHYLAELTALEQELSMSARLVSVTPALTELAGGCAEKARADEPYRRAVRVVRARLSATSAAILDRTPQQVLDLGLPPYETPAELGADLDTIDESLRGHGSALLADDRLALLREGVRVFGFHLCGLDMRQNSDAHEEVIGELLAWAGVHPDYRSLPEDERVELLAAELGTRRPLVADDAQLSDLARGELGVVRAAAHAIKRYGPSAVPNYVISMCRSVSDVLEAAILLKEAGLIDASGPEPYCPVGISPLFETIDDLHNGATILHAMLELPIYRALVAARGETQEVMLGYSDSNKDGGYLASSWAVYRAELALVEVARKTGIRLRLFHGRGGTVGRGGGPSYEAILAQPPGAVNGSLRLTEQGEVIAAKYAEPQAAQRNLESLLAATLESTLLDVEGLGDAAEPAYAVLDEVAVLAQRAYAELVHDTPGFVDYFMASTPVSEIGSLNIGSRPTSRKPTESISDLRAIPWVLAWSQSRVMLPGWYGTGSAFEQWIAAGPQSEAERVSILHDLYQRWPFFRSVLSNLAQVLAKSDLGLAARYAELVGDEELRRRVFGKIVDEHGRTIAMHKLITGQDNLLADNPALARSVFNRFPYLEPLNHLQVELLRRYRSGDDDELVQRGILLTMNGLASALRNSG
>NZ_CP022223.1|WP_003876059.1|3797503_3797737_-|preprotein-translocase-subunit-SecG
MQLALQITLVVTSILVVLLVLLHRAKGGGLSTLFGGGVQSSLSGSTVVEKNLDRLTLFITGIWLVCIIGMALLIKYR
>NZ_CP022223.1|WP_008258127.1|3797767_3798553_-|triose-phosphate-isomerase
MSRKPLIAGNWKMNLNHFEAIALVQKIAFALPDKYYDKVDVTVLPPFTDLRSVQTLVDGDKLRLTYGGQDLSQHDAGAYTGEVSGAFLAKLGCTFVVVGHSERRTYHHEDDAVVAAKTAAALKHELTPIVCIGEHLEVREAGNHVIHCEEQLRGSLAGLSAEQIGKVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPQVADSVRVLYGGSVNAKNVGELVAQGDIDGGLVGGASLDGEQFATLAAIAAGGPLP
>NZ_CP022223.1|WP_089151922.1|3798549_3799785_-|phosphoglycerate-kinase
MAVHTLKDLLGEGVSGRGVLVRSDLNVPLEDGKITDPGRITASVPTLKALVEAGAKVVVTAHLGRPKDGPDPKLSLAPVAAALSEQLGRHVQLAGDVVGTDALARAEGLTDGDVLLLENIRFDARETSKDDGERLALARKLAELVGPTGAFVSDGFGVVHRKQASVYDIATLLPHYAGTLVAEEIQVLQQLTSSTKRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQGFSVGKSLLETEMVDTCRRLLDTYVDVLRLPVDIVVADKFAADATPHTVAADAIGDDLMGLDIGPGSVKRFTTLLSNAETVFWNGPMGVFEFPAFAAGTKGVAEAIAAATGKGAFSVVGGGDSAAAVRALGIPEGDFSHISTGGGASLEYLEGKTLPGVEVLDRPQPTGGAA
>NZ_CP022223.1|WP_065500588.1|3799788_3800808_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTVRVGINGFGRIGRNFYRALLAQQEQGTADIEVVAVNDLTDNASLAHLLKFDSILGRLPHDVSLEGDDTIVVGNAKIKALEVKEGPAALPWGDLGVDVVVESTGIFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLGPLAKVLNDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVLPELKGKLDGYALRVPIPTGSVTDLTAELRKSATAEEINAAMKAAAEGPMKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVALVGKSL
>NZ_CP022223.1|WP_042912379.1|3800935_3802366_-|NAD(P)/FAD-dependent-oxidoreductase
MARAVVVGAGPNGLAAAIHLARHGVDVQVLEAGETVGGGARSAELTVPGVIHDVCSAAHPMAVGSPFWQEIDLPSYGLTWKWPEVDCAHPLDDGTAGLLYRSIDRTVAEMGADGRRWRLAVGDLSAGFDELCQDLMRPVLHVPHHPIRLAAFGPRALLPATVLARWFRTERVRALYGGQAAHAYTRLDRPLTAAMALMFMASGHHYGWPVAAGGSGSIIAALAAVLAEHGAAITTGVTVTSRKDIPDADIVMLDLTPAATLRLYGDAMPGRIKRSYRRYRQGSSAFKVDYAIEGHIPWTNPDCGHAGTVHLGGTFAEIAHSERERSQGRMYRRPFIILGQQYLADPSRSAGNINPIYAYAHVPFGYTGDATEIITDQIERFAPGFRDRVVATVTSGTADLQAYNPNFIGGDIIGGANDGLQVILRPRVSVNPYATGVPGVYLCSQSTPPGAGIHGLCGYHAAEAALGWLRKRRNPA

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Crispr_ID: NZ_CP022223_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_6

3964523-3964691

Orphan

Consensus_repeat	Method
GGGGCGGGGCCGGCTGGCCCGGTGCGGGTTGGCCGCTGGGCCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_6

>merge|NZ_CP022223|6|3964523-3964691|CRISPRCasFinder
GGCTGGGCGCCGGCTGCCCCGGCGCGGGCTGTCCGGCCGGGGCGGGGCCGGCTGGCCCGGTGCGGGTTGGCCGCTGGGCCCGGTTCTGCGGGCGCGGGTTCTGCGGGCGCGGGCTGTCCGGCCGGGGGCGGGGCCGGTTGGCCCGGTGCGGGTTGGCCGCTGGGCCCGG

>NZ_CP022223|6|6|3964523-3964691|CRISPRCasFinder
GGCTGGGCGCCGGCTGCCCCGGCGCGGGCTGTCCGGCCGGGGCGG	GGCCGGCTGGCCCGGTGCGGGTTGGCCGCTGGGCCCGGTTCTGCGGGCGCGGGTTCTGCGGGCGCGGGCTGTCCGGCCG
GGGGCGGGGCCGGTTGGCCCGGTGCGGGTTGGCCGCTGGGCCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_089152452.1\|3955612_3956281_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_CP022223.1\|WP_008258315.1\|3970884_3971577_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_094081036.1\|3967296_3970821_+\|carboxylic-acid-reductase	unknown	unknown	gnl\|CDD\|341287
NZ_CP022223.1\|WP_008260795.1\|3951089_3951716_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225695
NZ_CP022223.1\|WP_014385306.1\|3974023_3974623_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_CP022223.1\|WP_089151960.1\|3953167_3954292_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_CP022223.1\|WP_089152454.1\|3961984_3963274_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP022223.1\|WP_014382855.1\|3965678_3965792_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_089151961.1\|3954346_3955609_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NZ_CP022223.1\|WP_094081038.1\|3974619_3975174_-\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NZ_CP022223.1\|WP_094081037.1\|3972191_3972878_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237522
NZ_CP022223.1\|WP_009956162.1\|3972971_3974027_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_CP022223.1\|WP_089152453.1\|3960275_3961922_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP022223.1\|WP_008258310.1\|3965278_3965605_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235636
NZ_CP022223.1\|WP_087139743.1\|3956360_3957290_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_CP022223.1\|WP_008258316.1\|3971706_3972093_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|377753
NZ_CP022223.1\|WP_089151962.1\|3959725_3960268_-\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_CP022223.1\|WP_008258303.1\|3957302_3959681_-\|RelA/SpoT-family-protein	unknown	unknown	gnl\|CDD\|213552
NZ_CP022223.1\|WP_072501373.1\|3951712_3953152_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|238206
NZ_CP022223.1\|WP_009953660.1\|3965816_3967157_+\|4-aminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|235685

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_089152452.1\|3955612_3956281_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	3.17673e-66
NZ_CP022223.1\|WP_008258316.1\|3971706_3972093_-\|DUF1304-domain-containing-protein	gnl\|CDD\|377753	pfam06993, DUF1304, Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	1.54796e-27
NZ_CP022223.1\|WP_094081036.1\|3967296_3970821_+\|carboxylic-acid-reductase	gnl\|CDD\|341287	cd17632, AFD_CAR-like, adenylation domain of carboxylic acid reductase (CAR). This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.	0
NZ_CP022223.1\|WP_008260795.1\|3951089_3951716_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	4.48638e-07
NZ_CP022223.1\|WP_014385306.1\|3974023_3974623_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	2.55483e-75
NZ_CP022223.1\|WP_089151960.1\|3953167_3954292_-\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.57203e-74
NZ_CP022223.1\|WP_089152454.1\|3961984_3963274_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	4.62289e-112
NZ_CP022223.1\|WP_089151961.1\|3954346_3955609_-\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
NZ_CP022223.1\|WP_094081038.1\|3974619_3975174_-\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	1.5018e-77
NZ_CP022223.1\|WP_094081037.1\|3972191_3972878_-\|hypothetical-protein	gnl\|CDD\|237522	PRK13822, PRK13822, conjugal transfer coupling protein TraG; Provisional.	0.00515149
NZ_CP022223.1\|WP_009956162.1\|3972971_3974027_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP022223.1\|WP_089152453.1\|3960275_3961922_-\|hypothetical-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.07436e-72
NZ_CP022223.1\|WP_008258310.1\|3965278_3965605_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235636	PRK05886, yajC, preprotein translocase subunit YajC; Validated.	3.73943e-60
NZ_CP022223.1\|WP_087139743.1\|3956360_3957290_+\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	8.5068e-45
NZ_CP022223.1\|WP_089151962.1\|3959725_3960268_-\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	4.06653e-73
NZ_CP022223.1\|WP_008258303.1\|3957302_3959681_-\|RelA/SpoT-family-protein	gnl\|CDD\|213552	TIGR00691, PppGpp_synthetase., (p)ppGpp synthetase, RelA/SpoT family. The functions of E. coli RelA and SpoT differ somewhat. RelA (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC 3.1.7.2) degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species. [Cellular processes, Adaptations to atypical conditions].	0
NZ_CP022223.1\|WP_072501373.1\|3951712_3953152_-\|recombinase-family-protein	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	4.17593e-39
NZ_CP022223.1\|WP_009953660.1\|3965816_3967157_+\|4-aminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|235685	PRK06058, PRK06058, 4-aminobutyrate--2-oxoglutarate transaminase.	0

>NZ_CP022223.1|WP_089152454.1|3961984_3963274_-|protein-translocase-subunit-SecF
MVSNDATEITETSAGTTELTASAAGTAGAPHHSFLSRLYTGTGAFEVVGRRRLWFGISGAIVAVALLSIVLRGFSFGIDFNGGTTVSMPANGTHGTVRTSQVQDVFRKTLGNDAESVVVVGNGAAATVQIRSETLSNDQTTKLRNALFDAFGPKGPDGKPSKQAISDSAVSETWGDQITMKALFALVVFLALVGVYITVRYERYMTLAAIAAMFFDLAVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHKPKRTFAEEANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIVGTYSSIFFATPLLVSMRERTELVRTHTRRVLRRRAGGARGGAENAPDADDEAAGDTKADAGESASTASGPSKPAPSKPAPGARPVRPTGTRRPTGKRNVGRR
>NZ_CP022223.1|WP_089152453.1|3960275_3961922_-|hypothetical-protein
MALWISAGLAVALVAGFVVTACAGSAASEVDYVVDGPLSTYNTNTVAGAASAGAQAFARTLTGFSYHGPGGQIVADRDFGTVSVVGGTPLVLDYQIADNAVYSDGKPLTCDDIVLAWAAQSGRFPEFDAATQGGYIDIANVECIPGQKKARVSFVPDRGVVDYNQLFTATSLMPSHVIADQLNVDVTAALLSHNAPLVQQIAKLWNTIWDLKPGLQKDVLEKRFPSSGPYKIGSVLEGGAVVLVANDRWWGPRAITKRITVWPQGPDIQDRVNNRTVDVVDVAAGSSGTLATPDNYERSDAPSDGIEQLFFAPQGPLAAPKARRAVALCTPRDALAHDAGTPIANSRLSPAGDDAVTAADGAAEAGPFGKADPVAARNALGGAPLAVRIGYQGPNARLAVNVGVITKSCAAAGITVTGVTLDSSGPRALRDGKIDALLASTGGATGSGSTGSSALDAYALHTGNGNNLSGYSNPQVDSAIGALAVSADAAERVRLLAETAPILWGDMPTLPLYRQQRTLLMSKKMYAVSNNPTRWGVGWNMDRWALVQ
>NZ_CP022223.1|WP_089151962.1|3959725_3960268_-|adenine-phosphoribosyltransferase
MTNVGGRTPVAELIASLTRKVADFPEPGIQFKDLTPVFADATAMTAITGAVAELASGADLVAGIEARGFLVAAAVADRLGTGVLAVRKAGKLPPPVHAERYDLEYGTATLEIPGEGIDLRGRNVVIVDDVLATGGTLAASARLLERAGANVTAAAVLFELGGLGGRDAVAPLPVHSLMCE
>NZ_CP022223.1|WP_008258303.1|3957302_3959681_-|RelA/SpoT-family-protein
MADDNSASQALDAPTKVTEPPAITQPMEAPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNPVLEPLVAVHREIYPKANVSMLQRAFEVADQRHATQLRHSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTGYTLDALSEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVSTLGASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVPHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAKERREEALEAGKDAMAREVRRGGLPLQRLVNGETLSAVARELHYLDVSALYTAIGEGHVSARHVVQRLLAELGGIDQAEEDLAERSTPTTMLRRPRSSDDVGVSVPGAPGVLTKLAKCCTPVPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVHWAPSPSSVFLVAIQVEALDRHRLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVTSAA
>NZ_CP022223.1|WP_087139743.1|3956360_3957290_+|peptidylprolyl-isomerase
MGLRSNHGGIAAVPTNEQRRANAKRKLERQLERRAKQAKTRRIVLIAAGSIVAVAVVVAVVLTIVNTKHEHKSNTAATTTTSSSSPESTTPAGPAPSAPPLPAFKPSAEVGANCQYPATPEPAAKQVKPPRTGKVPTDPAQVSVSMVTNQGHIGLMLANNESPCTVNSFASLVGQKYFDNTKCHRLTTSPGLGVLQCGDPKGEGTGGPGYQFANEYPTDQYPPNDPKAQEPVLYPRGTLAMANAGPGTNGSQFFMVYKDSQLPPQYTVFGTIQPDGLATLDKIAKAGVAGGGEDGAPATEVTITSVLLD
>NZ_CP022223.1|WP_089152452.1|3955612_3956281_-|MBL-fold-metallo-hydrolase
MLITGFPAGMLQCNCYVLAERPGTDAVIVDPGQRAMAPLRRILDENRLTPAAVLLTHGHIDHMWSAQKVSDTYGCPTYIHPEDRFMLKDPIYGLGPRLAQLVAGAFWREPKQVVELDRDGDKLDLGSVTVNVDHTPGHTRGSVVFRVHGGTKDGKDLVFTGDTLFERSVGRTDLFGGSGRDLLTSIVDKLLVLDDATVVLPGHGNATTIGAERRLNPFLEGL
>NZ_CP022223.1|WP_089151961.1|3954346_3955609_-|histidine--tRNA-ligase
MAEFSAPKGVPDYVPPDSAEFVAVRDGLLGAARRAGYGDIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAVADAGFRSLGLDGFRLEITSLGDDSCRPAYRELLQEFLFGLSLDDETRWRAEINPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRELGGQDLSGIGFGLGVDRTLLALRAEGKGVGSAARCEVFGVPLSEQAKLRLAVLAGQLRAAGVRVDLAYGDRGLKGAMRAADRSGARVALVLGDRDIEAGTVGVKDLGTGEQSAVASESVVADVLARLDR
>NZ_CP022223.1|WP_089151960.1|3953167_3954292_-|HNH-endonuclease
MFDEVRRRAVIAELDELVERCHPSSTRESAALLEQIGVVARVENRAAAAQLVAVGELFAYRLSRCAESEEWAVDTEAAVAAEVGAQLRIGQGLAASRVRYARAMRERLPKVGAVFAAGDIDYRMFQTIVFRTDLITDLDVLRSVDAALAATVARWPSLSQGRLAAQVDKVVAKADVDAVRRRQERVAGRQVWMADMGDGLAHLEGTLYAADAHALDRRLDALAATVCAHDPRTREQRRADALGALAADADRLGCRCGRPDCAAGERAAGPVVMHVIAPQTSAGWAPGVQIGAEGLIPPEVLAELAASARLVPLAHPADAPPEAGYVPSRALADFVRCRDLTCRWPGCDRPATACDVDHTIPYAAGGPTHASKLR
>NZ_CP022223.1|WP_072501373.1|3951712_3953152_-|recombinase-family-protein
MSRRKATAQRVGVQSAAVYARISADVEGAGLGVARQLEDCRKLAADRGWPVGDEYVDNDVSAFSGKPRREYARMLADLESGARDAVLVYNLDRLHRRPVELEEFVALCESVGVRDVATVTADIDLGNDDGLFMARIFAAFAAKESGRKSARIRRKMLQNAEQGRPHGSVRPFGYEPDKITVRSEEAAVVREMVDRYLAGASIRSLTMWLNDSGIAPAASKSWRTSAVRQILCSGRVAGLREHHGQVIGEAAWPAIISPMQRDQVLARMTARALTKTRAPRTYLLSGLLRCGRCGNRLYSQARHVNPENRVRRYVCLSGPDQGGCGRLTVVAQPVEDLLTDAVLTRLDSPALADALVGKSSVDANVAELSVQLDADTARLDELAALYADGAVTAREWIAARDPITARIAQTRKAIAAATDTADVNELAGTGHLLREQWDSLDIDRQQAVIKSVLGHAVIAPGTPGARSLDINRVHPHWRI
>NZ_CP022223.1|WP_008260795.1|3951089_3951716_+|GNAT-family-N-acetyltransferase
MARKKIGIQDASIAEIEDLERWQILAGIGPGSALGEDLAEAKESGVLSHALRGGIKHARSINQYANMFDSLCARTLVLSARSGAKTVGLLLLGPPPALLQRGPQFNGQNAAFLFHVAKLGVLAVDPTVHGTGIGSRLVRVGTDIARQSGYLVLYGEFHADRPALPTFYERCGFEVLETDQALNLTEVMGFPTLIKPTGSDRLFVTGLT
>NZ_CP022223.1|WP_008258310.1|3965278_3965605_-|preprotein-translocase-subunit-YajC
MESLILFLPFLLIMGGFMYFASRRQKRAMQATIDLHESLSPGDRVHTTSGLQATVVAITDDTVDLEISPGVVTTWMKLAIRDRILPDDDEDLVDGDEPADEGSVAKDS
>NZ_CP022223.1|WP_014382855.1|3965678_3965792_-|hypothetical-protein
MSRHVESLSSLPPAGIGRTAAAGDGPRPARLNGHTGP
>NZ_CP022223.1|WP_009953660.1|3965816_3967157_+|4-aminobutyrate--2-oxoglutarate-transaminase
MAGLEQTRQLVTEIPGPLSLELSKRRAAAVSHAVNVSVPVFVARAGGGIIEDVDGNRLIDLGSGIAVTTIGNSAPRVVDAVRAQVAEFTHTCFMVTPYESYVAVAETLNRITPGSGEKRSVLFNSGAEAVENAVKVARAYTRKSAVVAFNHAYHGRTNLTMALTAKSMPYKAGFGPFAPEVYRAPLSYPYRDGLIDKELATDGEKAAARAIRVIDSQIGADNLAALLIEPIQGEGGFIVPAEGFLPTLLEWCRRNDVVFIADEVQTGFARSGAMFACEHEGIEPDLICTAKAIADGLPLSAVTGRANIMDAPHVGGLGGTFGGNPLACAAALATIETIESDGLVERAQQLERLITEPLLRLQAGDDRIGDVRGRGAMIAIELVKSGTAEPDKELTQKLTVAAQAAGVIVLTCGMFGNIIRLLPPLTIGDELLAEGIDILSGLLRDL
>NZ_CP022223.1|WP_094081036.1|3967296_3970821_+|carboxylic-acid-reductase
MSTAIHDGNLDRRIEELIANDPQFAAARPDPAITAATEAPGLRLPQIIRTVLDGYADRPALAQRVVEFVTDAKTGRTTAELLPRFETITYGELGERVSALGRAWAGDAVRPGDRVCVLGFNSVDYATIDIALGTIGAVSVPLQTSAAISSLQPIVAETEPSLIASSVNQLPDAVELILAGDHVPGKLVVFDYQPQVDDQREAVEAAAARLADSGVAVEALADVLRRGKDLPAPELPASDEDSLALLIYTSGSTGAPKGAMYPQSNVGKMWRRGSKNWFGGSAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDLSTLLEDLELVRPTEMNFVPRIWETLYGEFQRQVERRLADGDAGPEARETVAAEVLAEQRQYLLGGRFIFEMTASAPIAPELRNWVEALLEMPLRDGYGSTEAGIVLVDGEVQRPLVIDYKLVDVPDLGYFSTDRPHPRGELLVKTQTMFPGYYKRPETTASVFDEDGYYRTGDIFAEVAPERLLYVDRRNNVLKLAQGEFVTLSKLVAVFGNSPLIRQIYVYGNSVQSYLLAVVVPTEEALADNDVESLKPKIADSLQKVAKETGLQSYEVPRDFIIETTPFTLENGLLTGIRKLAWPKLKAHYGDRLEQMYAELAAGQANELAELRRNGAAAPVAQTVSRAAAAMLGAATSDLSPDSHFTDLGGDSLSALTFGNLLREIFDVDVPVGVIVSPANDLAGIAAYIEAERQGSKRPTFAAVHGRGATTVHASDLTLDKFLDEATLAAAPSLPTPATEVRTVLLTGATGFLGRYLALDWLERMDMVDGKVIALVRARTDEEARARLDKTFDSGDPTLLAHYQQLAADHLEVIAGDKGEANLGLDPQTWQRLAEQVDVIVDPAALVNHVLPYSELFGPNALGTAELIRLALTSRQKPYTYVSTIGVGDQIPPGEFVENADIRQISATRAINDGYANGYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTTYAGQLNLPDMFTRLMLSLVATGIAPGSFYELDADGNRQRAHYDGLPVEFIAAAISTLGTQITDSDTGFQTYHVMNPYDDGIGLDEYIDWLIEAGYSIERIADYSEWLRRFETSLRALPDRQREYSLLPLLHNYQKPQKPINGSMAPTDVFRAAVQEAKIGPDKDIPHVSAPVIVKYITDLELLGLL
>NZ_CP022223.1|WP_008258315.1|3970884_3971577_-|hypothetical-protein
MKYAEDGRTSALSMPRSRGAVSGLLLVILGAWGALIPFVGPHFNFAYTPDRNWAWSTARGWLEVAPGAATALGGLLLIVAGNRVAAMLGGWLAVLAGAWFVVGGDVAPLLGIGSAGDPIAATDRKRAVLEVTYFSGLGALIIFIGGVVLARTAVRLARDVQPLAPATTGTPAVEPYRDSVYEQPAEVSSGALTKPRASSDPEPKRGWRRHRAGAGSGGNAAYLRWPHPQQ
>NZ_CP022223.1|WP_008258316.1|3971706_3972093_-|DUF1304-domain-containing-protein
MITTALLFAALAALLHVYIFVMESLTWTSPRTRATFGTTPAEAETTKLLAFNQGFYNLFLAIVTGIGIAVIALGHTTVGAALVFAGIGSMAAAAVVLLVSAPDKARAALAQGTFPAMAIVLLLLGLQQ
>NZ_CP022223.1|WP_094081037.1|3972191_3972878_-|hypothetical-protein
MRNRRHDYERPRALYMPRTRGALTGLLLILLGAWGALVPFFGPNIDWAYATAPAWTWTAAKGWLEVLPGVAAAVGGLLVLLSGNRANAVFGGWLAVLGGAWFVVGRAFAPTLGIGDVGQPVAAADLKRALLEVTYFTGLGALIVFLGGAAVARLAVRHARDVVVTQPAPAAGDAAVPAAQPAMYDETGGMAPARTDAVPADAAPGERGGHGLFHRRPGGLFHRHHAGV
>NZ_CP022223.1|WP_009956162.1|3972971_3974027_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MTPAEEDWSDRDVSGALAPGEGDIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRLTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGGDAAEEIARRSRGTPRIANRLLRRVRDFAEVRADGVITRDVAKSALAVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEATTVEEVCEPFLVRAGMVARTPRGRVATAQAWTHLGMAPPAGAAGLGQPGLFE
>NZ_CP022223.1|WP_014385306.1|3974023_3974623_-|Holliday-junction-branch-migration-protein-RuvA
MIAAVRGEVLEVALDHAVIEAAGVGYRVNATPSTLSTLRTGTEARLITAMIVREDSMTLYGFTDTDTRDLFLTLLSVSGVGPRLAMATLAVHDAGALRQALHDGDVAALTRVPGIGKRSAERMVLELRDKVGAAGAGAAPAGAALNGHAVRGPVVEALVGLGFAVKQAEEATDKVLAAEQDATTSGALRAALSLLGKSR
>NZ_CP022223.1|WP_094081038.1|3974619_3975174_-|crossover-junction-endodeoxyribonuclease-RuvC
MRVMGVDPGLTRCGLSVVESGRGRTVVALDVDVVRTPSDAPLAERLLTISDAVEHWLATHEPDVMAVERVFSQLNVSTVMGTAQAGGVVALAAARRGIDVHFHTPSEVKAAVTGNGAADKAQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIARMAAAEALAAQQRQKYKAKLKAAR

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Crispr_ID: NZ_CP022223_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_7

4160512-4160608

Orphan

Consensus_repeat	Method
TGCCCGGCGTCGGCTGTGGCTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_7

>merge|NZ_CP022223|7|4160512-4160608|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGGTGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCCTGCCCGGCGTCGGCTGCGGCTCCGG

>NZ_CP022223|7|7|4160512-4160608|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGG	TGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCC
TGCCCGGCGTCGGCTGCGGCTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_042912581.1\|4170454_4171462_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239607
NZ_CP022223.1\|WP_042912568.1\|4156350_4157100_+\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|366780
NZ_CP022223.1\|WP_042912564.1\|4152852_4154064_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NZ_CP022223.1\|WP_009952956.1\|4166713_4167172_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_051445912.1\|4154116_4154851_-\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|274008
NZ_CP022223.1\|WP_008258632.1\|4166259_4166721_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP022223.1\|WP_042912569.1\|4157116_4158229_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP022223.1\|WP_036453354.1\|4155507_4156308_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP022223.1\|WP_008258618.1\|4152050_4152803_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|234847
NZ_CP022223.1\|WP_089152036.1\|4169375_4170458_-\|dihydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|226326
NZ_CP022223.1\|WP_089152460.1\|4172239_4173169_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|99782
NZ_CP022223.1\|WP_042912573.1\|4160631_4163868_-\|carbamoyl-phosphate-synthetase	unknown	unknown	gnl\|CDD\|237263
NZ_CP022223.1\|WP_008258652.1\|4171583_4172234_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|132427
NZ_CP022223.1\|WP_080691216.1\|4165438_4166269_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_CP022223.1\|WP_042913037.1\|4167168_4167906_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_CP022223.1\|WP_042913032.1\|4159421_4160204_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NZ_CP022223.1\|WP_042912571.1\|4158225_4159425_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP022223.1\|WP_008258621.1\|4154950_4155436_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP022223.1\|WP_042913030.1\|4151018_4151921_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NZ_CP022223.1\|WP_042912576.1\|4168010_4169369_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_042912581.1\|4170454_4171462_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239607	cd03531, Rieske_RO_Alpha_KSH, The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway, catalyzing the 9 alpha-hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD). KSH is a two-component class IA monooxygenase, with terminal oxygenase (KshA) and oxygenase reductase (KshB) components. KSH activity has been found in many actino- and proteo- bacterial genera including Rhodococcus, Nocardia, Arthrobacter, Mycobacterium, and Burkholderia.	7.16801e-30
NZ_CP022223.1\|WP_042912568.1\|4156350_4157100_+\|dienelactone-hydrolase	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	3.47996e-60
NZ_CP022223.1\|WP_042912564.1\|4152852_4154064_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.37232e-105
NZ_CP022223.1\|WP_042913037.1\|4167168_4167906_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	4.13355e-99
NZ_CP022223.1\|WP_051445912.1\|4154116_4154851_-\|cell-division-protein-DivIVA	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	2.28412e-05
NZ_CP022223.1\|WP_008258632.1\|4166259_4166721_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.40179e-12
NZ_CP022223.1\|WP_042912569.1\|4157116_4158229_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.57619e-42
NZ_CP022223.1\|WP_036453354.1\|4155507_4156308_-\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP022223.1\|WP_008258618.1\|4152050_4152803_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|234847	PRK00847, thyX, FAD-dependent thymidylate synthase; Reviewed.	3.54e-100
NZ_CP022223.1\|WP_089152036.1\|4169375_4170458_-\|dihydrodipicolinate-reductase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.50278e-37
NZ_CP022223.1\|WP_089152460.1\|4172239_4173169_-\|oxidoreductase	gnl\|CDD\|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	1.38118e-86
NZ_CP022223.1\|WP_042912573.1\|4160631_4163868_-\|carbamoyl-phosphate-synthetase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	5.77895e-168
NZ_CP022223.1\|WP_008258652.1\|4171583_4172234_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	0.000338941
NZ_CP022223.1\|WP_080691216.1\|4165438_4166269_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	6.49165e-22
NZ_CP022223.1\|WP_042913032.1\|4159421_4160204_-\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	1.12702e-124
NZ_CP022223.1\|WP_042912571.1\|4158225_4159425_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.80373e-131
NZ_CP022223.1\|WP_008258621.1\|4154950_4155436_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	5.01316e-61
NZ_CP022223.1\|WP_042913030.1\|4151018_4151921_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	7.08269e-146
NZ_CP022223.1\|WP_042912576.1\|4168010_4169369_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.2479e-79

>NZ_CP022223.1|WP_042913032.1|4159421_4160204_-|SDR-family-oxidoreductase
MTSQDLTGRTAIITGASRGIGLSIAQQLAAAGANVVLTARKQEAADEAAAQVGERAVGVGAHAVDEDAARRCVDMTLERFGTLDILVNNAGTNPAYGPLIDQDHARFTKIFDVNLWAPLLWTSLAVKSWMGEHGGSIVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPRVRVNAICPGVVRTRLAEALWKDHEDPLASSIALGRIGEPIDVAAAVAFLVSDAASWITGETMVIDGGLLLGAAQGFRPAPGGGQ
>NZ_CP022223.1|WP_042912571.1|4158225_4159425_-|acyl-CoA-dehydrogenase
MNAVDTAELDARVQALLDEHDPNESDAREFLGAQYDAGLAWVHLPRGFGGLDLPRTAQDRVDARLAAAGAPVGGTPKNYIGMGMAAPTIAAFGTDEQKRKFLRPLFTGEQIYCQLFSEPGGGSDLAGVSTRAVRDPHNPEDWIVNGQKVWTSQAQHAHMAILVARTDPAVPKHAGLTYFLCDMTQPGVEIRPLRQITGEAEFNEVFLTDVRVPDANRLGPEGGGWRVATTTLNNERVAIGSRAGAPREGGHIGKVADAWRAEPALRDPAMHDQLMRLWVEAEVFRLAGERLRQQAATGQPGPEGAGMKVAFAKLAQAISGFEIELHGESGLYYDDWTLRRPETVDLVGRGPGYRYLRARGNSIEGGTSEILRNTISERILGLPGEHRVDKDAAWKDLPR
>NZ_CP022223.1|WP_042912569.1|4157116_4158229_-|acyl-CoA/acyl-ACP-dehydrogenase
MSSLRAATGDLLYSDTEEALRAGVRQLFAERCPPESVAGVYDAQPQDFSGVWRTLATELGVAGLLVPESLGGAGASAREAAVVMEEIGRAVAPVPFLSSAVLATVALLRAGDTRTVSGLAQGELTAALVVPLTTAPGDPVTGVSGGPGGLSGSVTAVAGAGEADVLVVPVTGPDGLELHTVDRAAAGVQVSPLLALDMTRPLAAVTFSGAPSSKVGAGDGPVADAVRTGAALLASEQLGVAQWCFDTTLDYAGQRRQFGRTIGSYQAIKHRLADLWFDVGAAAAAARYAADTCARADDDAAAAAAIAQAYCSDIAVHAAEECIQLHGGIGMTWEYPAHLYLKRAKSDQLAFGTGYRHRARLAELVNLPPT
>NZ_CP022223.1|WP_042912568.1|4156350_4157100_+|dienelactone-hydrolase
MPNITDVVTTPDGTCPVHLFTPDGPESQVPWPGVVMYPDAGGVRGTFEEMAARLAGFGYAVLLPDVYYRTADWAPFDMATVFNDQSERGRLFSMIGSVTPDRMAADATAFFDYLAARPEVSGERFGVCGYCMGGRTSLIVAGRVPDRVAAAASFHGGGLVTDTDDSPHLLADRMSATVYVGGAQNDASFTADHAEQLDKALTAAGVEHTIEWYSAGHGFAVPDNAPYDPAAAERHWDAMTDVFAAAFPR
>NZ_CP022223.1|WP_036453354.1|4155507_4156308_-|thymidylate-synthase
MPIPTPYEDLLRLVLDEGTAKSDRTGTGTRSLFGRQLRYDLSAGFPLLTTKKVHLKSVVYELLWFLRGDSNVGWLREHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPNSRRIIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQSGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLGERDSIFDYTYDDVVVRNYDPHPAIKAPVAV
>NZ_CP022223.1|WP_008258621.1|4154950_4155436_-|dihydrofolate-reductase
MGLVWAQSTSGVIGRGGGIPWNVPEDLARFKEVTIGHTVVMGRRTWDSLPAKVRPLPGRRNVVLSREDGFAADGAQVVGSLDAAFARAEGEPAVWVIGGGQVYLAALPYATRCEVTEIELDLRRDDDDALAPALDDTWVGETGEWQASRSGLRYRFHSYRR
>NZ_CP022223.1|WP_051445912.1|4154116_4154851_-|cell-division-protein-DivIVA
MITEPVKTFSRKFMGYDASAVDAHIEMLTTKQQLLLDDVESLRARLQESGEQTAALRKEVAALTDTSPSSHAMQKRMAKMLQRAVDEVAEMQAEARAEADALIAAAEAEAEAAERKRDEVLADMAAQQKALEAEYEQTKEKLDAELAEMRAETQAAIDEARRNAERECERLLGDAKQGADHYRDKARRAVDEATAQRIEILEQLMGVYRDLDGVPAALEAAYQEQKNPSEDGALAPVDGKVRAS
>NZ_CP022223.1|WP_042912564.1|4152852_4154064_-|winged-helix-turn-helix-domain-containing-protein
MSTRRLSAAQARRIAVAAQGFTEPRPGGQITRVHLKRLISRIQVLQLDSVSVAVRAHYAPVFSRLGPYDRDVLDRAAWGLRSSRLLAEYWAHEAALMAVEDWPLLRWRMRQYRHGRWGTHIVKANPRLAEKVVAAVAELGPSTAGQIEAHLAAGPRGPRGSWWGSRSDTKWVAEALFSAGVLTTATRVGFARHYDLVERVLPAAVLAREVDDDEALRELTLRAATALGVGTEADIRDYFRLSAAQVKPAIAQLLAAGDIERVDVDGWSGPAYLRAGRTVPRVDRGTALLCPFDPLIFFRPRVERLFEFHYRIEIYTPAAKRQYGYYVWPLLMDGRLVARVDLKADRPADTLRVVGTFAEPDAPKARVAAALAGELRSMASWLGLGGFSVSGRGDLAADLRAIS
>NZ_CP022223.1|WP_008258618.1|4152050_4152803_-|FAD-dependent-thymidylate-synthase
MAEIAPLRVQLIAKTEFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHLSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPETDSHVVVPPGMEDDPELRQILAAAADASRATYTELLAKLEAKFADQPNAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAGAAPAVFADFEISALADGTEVATSPLATEA
>NZ_CP022223.1|WP_042913030.1|4151018_4151921_-|4-hydroxy-tetrahydrodipicolinate-synthase
MSTAGFDAPARLGTVLTAMVTPFRPDGSLDTATAAHLANHLIDAGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGSYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQSGLIAHFTTVADATALPVVLYDIPPRSVIPIQPETIRALAAHPNIVGIKDAKADLHSGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLREMLSAFNSGDIATARKINSTVAPLCDAMARLGGVTLSKAGLRLQGIDVGDPRLPQMPATPEQIDALAVDMRAASVLR
>NZ_CP022223.1|WP_042912573.1|4160631_4163868_-|carbamoyl-phosphate-synthetase
MSASLLVANRGEIALRIIRTATELGMRTIAVYADDDAQSPHVHAADEAIVLPGSGPRAYLDQSAMLAVAKRTGADLIHPGYGFLSENAEFADACVAGGVTFVGPDPGVLGLLGNKTAARGAALAAGVPVLPATDGASSVEEVAAFFAAQRGGIMLKALAGGGGRGMRKVHRADQIDDAYQRCAAEAQLGFGDPALYAEALLDDARHIEVQVVAAPAGHQTHALAVGDRDCSIQRRYQKLVEIAPAQGLSDELRRALHQAAVRLCARVGLRGLATVEFLVTGEDFVFLEANPRIQVEHTVTEEITGLDLVAVQLAIAGGTSFYGLGLPAGIASDGLEVIGEPAAQRGIAIQLRVNAETFGPDLSVLPSAGTLTAFTPPSGPGVRVDTYGRPGLAVSPQYDSLLAKVIVHVRGTSWPAALRKADTALSEFGIEGIHTNIGFLRELLRAERVESGWVSTGFVDEKLPELARATQSHQQEPPPASVELYPGEEALRAQLAGTVVEVAPEGVEHAAGSQLVVLEAMKMQHVLVAPDALRTVRTLVTPGQVVGTGDPLLIFTRTESGNDGESARAATDLDRPRADLDEVTRRHALTLDEGRAAAVAKRHQQGRRTARENIADLVDPGSFVEYGALAIAAQRSRRSEEDLIANTPADGLVAGLATIGAQRFGRAAAQAVVVSYDYTVLAGTQGMRNHAKTDRAFDLAARKRLPVVLFAEGGGGRPGDTDVGGAAGLDVPTFRMLAGLRGEVPLVSIVSGRCFAGNAALAGVCDVIIATPDANIGMGGPAMIEGGGLGVYPPEAIGPIGVQRRNGVVGLVARDEAHAVALAKQYLSYFQGSLGEWEEPDPRLARHVVPQNRLRAYDVHRAIEAIVDVGSVLELRPDYGVGIVTALVRVEGVPYGLIANSTHHLGGAIDAEAADKTGDFLALCESFGLPVISLCDTPGFMVGPDAETQAAVRRFGRMFVLGARLTVPLGMIILRKAYGLGAMAMAGGSFRAPQFTIAWPTGEIGGMGLEGAVRLGYSKELAAAEESGDPAERQSLFDRLVAAAYEHGKALRAATTFELDDVIDPSASRAWITRLSGG
>NZ_CP022223.1|WP_080691216.1|4165438_4166269_+|thioesterase-family-protein
MTNDSAIMPEAFFTVDGDSYVPGAMTQGPWGAAMGGQIVGGLLGWGIEQSGVDADLQPARFTVDLLRPALMSPVQIRTSVLREGRRIKLVDGELVQNGTVVARASALFLRRGDHPDGRVWSFPVEMPPLPTSSDGFPEAMPFLIWGYGATRDGSPGIAAGEWEQSDSQKFAWARIFRPMVQGHPLTPFTRLAFAGDITSSLTHWGTGGLRYINADYTVTASRLPDGEFLGLAAQSHYGTAGVATGAATLFDRHGPLGTSSALALAQPADAFKPTYA
>NZ_CP022223.1|WP_008258632.1|4166259_4166721_-|flavodoxin-family-protein
MSKTLLIVHHTPSPHTHEMFEAVVSGATDPEIEGVEVLRRPALTVSPAEMLAADGYLLGTPANLGYISGALKHAFDCSYYQLLDSTRGRPFGLYLHGNEGTEGAERAVDTITTGLGWSKAAETVVVSGKPGKEQLQACWELGATVAAQLMDYA
>NZ_CP022223.1|WP_009952956.1|4166713_4167172_-|hypothetical-protein
MTKALRTQLLVAFMCVALLVYFALLGRVAVAMIASGRAAAVGLGLAVLVMPVIGLWAMVATLRAGFAHQRLARLIAADGMELDTSDLPRRPSGRIQRDAADALFATVRTEVEDHPDDWRRWYRLARAYDYAGDRRRAREAMKTAVNLQGDHE
>NZ_CP022223.1|WP_042913037.1|4167168_4167906_-|4-hydroxy-tetrahydrodipicolinate-reductase
MRVGVLGAKGKVGSTMVAAVQAAEDLTLSAEVDAGDPLSLLTDGGTEAVIDFTHPDVVMGNLEFLIGNGIHAVVGTTGFTAERLQQVRAWLAESPKTSVLIAPNFAIGAVLSMHFARQAAPFFDSAEVIELHHPHKADAPSGTATRTAKLIAESRKGLPPNPDATSTSLPGARGADVDGIPVHSVRLAGLVAHQEILFGTEGETLSIRHDSLDRTSFVPGVLLAVRRITEHPGLTVGLEPLLNLQ
>NZ_CP022223.1|WP_042912576.1|4168010_4169369_+|HNH-endonuclease
MHSIEVPPEVSAALDALDAAAAAIRGLNFDQLDPAVRLRALERMEASRRRQIAVSHDVIAGLAREDPAALGGPVHKVIADWLRIGCGEASRRLHDATRLSPRLTLTGQELPPELPATAVAWRDGLLDGQHLRVIQSFVRDLPASTPVAKVETAERFLANEAAKLRPDQLQKLAHRYALSINPDGKFSDADRARQRGFTWCGQSPDGMSVGKLVASPELRANLDAWMSHFAAPGMCNPDDETPCVAGEPDDERVRRDLRSHAQRQHDALNALVRGQLGDPKLGQHNGLPVAVIVATTLRELTSGTGRAVTGGGTLLPMRDVIRMGRHAYHYLAVFDEHSSRPLYLGRSRRIASPDQRVVLYAQDRGCTHPGCDAPGYWCEAHHLKEWAAGGATDADNLTFACGPHHRLVEKGWRTRKNARGDTEWIPPPRLDRGVRTNDYHHPERGIGDRAGP
>NZ_CP022223.1|WP_089152036.1|4169375_4170458_-|dihydrodipicolinate-reductase
MSTAPIRVFQVGSGNVGSEMIRRIATQPDLELIGVHAYSPEKVGTDTGEFAGLGTNGVKFTGTIEEIIAAKPDVLTFHGVFPDEDLYLHVLEAGIDIVTTADWITGWHRDTNHPHPSGKPVSKLLAEACQKGGATFYGTGMNPGLNQILGVVCSADVADIENITTIESVDVSCHHSKDTWIEVGYGQPVDDPDIPSKLEKYTRVFADSVYMMADCFDLTLDEVAFSYELGACTKDVDLGWYTLPKGSLGGNYIRYQGMVDGVPRVETHLEWQMTPHTDPRWNIKGCYITQIKGDPCIYNKHMIFPKPGVDLSNPDSFASIGMTVTGMPALAAIKSVIAAPPGLITSADLPLRGFAGRFKK
>NZ_CP022223.1|WP_042912581.1|4170454_4171462_-|Rieske-2Fe-2S-domain-containing-protein
MAKPPLSMKPTGWFQVAWSDEIGVGDVHKIKYFDSEMVAWRAESGQLTVMNAYCEHLGAHLGYGGTVVGEVLQCPFHGWQWSADGRNVCIPYQDRPNRGRRMRTYPVVERNASVYIWHDVERREPYFEPPDVFAAFDDGSSADDYYPQQRLYRETLEMHPQYVLENGVDFAHFKFVHKTPIVPVFTRHDFAEPVSYVDFTITFEGDDGQKIEDVNSGVQAINGGLGIAVTKSWGMIDNRTISAITPVDERTSDVRFMVYIGRAPGGDSERAERKAAEFGQEVIRQFTQDIEIWQHQRYSDPPALAPDEYEGFTAIRQWAKQFYPEAFVSQEGLAQ
>NZ_CP022223.1|WP_008258652.1|4171583_4172234_+|TetR/AcrR-family-transcriptional-regulator
MTRQTSGAGIAGRRPNRRGHATRESMLEAALRSLASGEPGSVSANRIAKDIGATWGAVQYQFGDTDGFWAAVLHRTAERRAATFSTLSAPISPDAPLRERVGAIIDTLYTGLASADSRAIENLRAALPRDPDELERLYPRTAAELFSWGKSWLETCQQAFAGLAVDPDRVREVAALIPGAMRGLVSERQLGSYADLDMARRGLTNALAAYLEPSRP
>NZ_CP022223.1|WP_089152460.1|4172239_4173169_-|oxidoreductase
MQRTLTAVVTQRELVAPDVVALTLADPDGGLLPSWTPGGHIDVLLPSGRRRQYSLCGPPGRRTDYRIAVRRIAAGGGGSIEMHEALGVGDTCEFEGPRNAFYLGTAERDVLFVIGGIGVTPILPMIRAAAQRGIDWHAIYTGRGREYMPLLDEVVSVDPDRVTVWADDEHGRFPSVAELLAGAGPATAVYVCGPSAMLEAVRIARDQYAGAPLHYERFSPAPVVDGVPFELELARSRRVLAVPANRTALDVVLDRDPTTPYSCRQGFCGTCRVKVVAGQVDHRGRASPGDDGMLVCVSRADGGRVVIDA

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Crispr_ID: NZ_CP022223_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022223_8

4716359-4716492

Orphan

Consensus_repeat	Method
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022223_8

>merge|NZ_CP022223|8|4716359-4716492|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTACCCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGGGGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

>NZ_CP022223|8|8|4716359-4716492|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGG
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022223.1\|WP_080691230.1\|4725377_4725614_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022223.1\|WP_042913108.1\|4709786_4711145_+\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|227607
NZ_CP022223.1\|WP_008259667.1\|4726765_4727620_-\|TIGR02569-family-protein	unknown	unknown	gnl\|CDD\|131620
NZ_CP022223.1\|WP_054585280.1\|4722164_4725290_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP022223.1\|WP_008259631.1\|4712128_4713472_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_CP022223.1\|WP_042913111.1\|4713481_4713733_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP022223.1\|WP_042913117.1\|4727655_4728843_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NZ_CP022223.1\|WP_042913114.1\|4716503_4716758_+\|mycoredoxin-Mrx1	unknown	unknown	gnl\|CDD\|131255
NZ_CP022223.1\|WP_026071234.1\|4705587_4708566_-\|UPF0182-family-protein	unknown	unknown	gnl\|CDD\|234609
NZ_CP022223.1\|WP_042913113.1\|4714137_4716258_-\|ATP-dependent-DNA-helicase-UvrD2	unknown	unknown	gnl\|CDD\|223288
NZ_CP022223.1\|WP_042913105.1\|4703478_4703832_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380331
NZ_CP022223.1\|WP_014712233.1\|4726447_4726759_+\|DNA-methyltransferase	unknown	unknown	gnl\|CDD\|226219
NZ_CP022223.1\|WP_014712227.1\|4716769_4717702_-\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699
NZ_CP022223.1\|WP_041298262.1\|4704639_4705584_+\|GlxA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227311
NZ_CP022223.1\|WP_054585282.1\|4718820_4722168_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP022223.1\|WP_042913107.1\|4703851_4704502_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|188314
NZ_CP022223.1\|WP_042913109.1\|4711180_4712047_+\|cyclodehydratase	unknown	unknown	gnl\|CDD\|274832
NZ_CP022223.1\|WP_009955776.1\|4708639_4709662_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP022223.1\|WP_042913116.1\|4725659_4726445_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP022223.1\|WP_008259653.1\|4717701_4718772_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|367001

Protein	Function_ID	Function_description	E-value
NZ_CP022223.1\|WP_042913108.1\|4709786_4711145_+\|zinc-dependent-metalloprotease	gnl\|CDD\|227607	COG5282, COG5282, Uncharacterized conserved protein [Function unknown].	7.68796e-161
NZ_CP022223.1\|WP_008259667.1\|4726765_4727620_-\|TIGR02569-family-protein	gnl\|CDD\|131620	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein. This protein family is found, so far, only in Actinobacteria, including as least five species of Mycobacterium, three of Corynebacterium, and Nocardia farcinica, always in a single copy per genome. The function is unknown. [Hypothetical proteins, Conserved].	4.73137e-135
NZ_CP022223.1\|WP_054585280.1\|4722164_4725290_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	9.21813e-72
NZ_CP022223.1\|WP_008259631.1\|4712128_4713472_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	3.1123e-124
NZ_CP022223.1\|WP_042913111.1\|4713481_4713733_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	2.08659e-14
NZ_CP022223.1\|WP_042913117.1\|4727655_4728843_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NZ_CP022223.1\|WP_042913114.1\|4716503_4716758_+\|mycoredoxin-Mrx1	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	4.87391e-42
NZ_CP022223.1\|WP_026071234.1\|4705587_4708566_-\|UPF0182-family-protein	gnl\|CDD\|234609	PRK00068, PRK00068, hypothetical protein; Validated.	0
NZ_CP022223.1\|WP_042913113.1\|4714137_4716258_-\|ATP-dependent-DNA-helicase-UvrD2	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	5.30193e-121
NZ_CP022223.1\|WP_042913105.1\|4703478_4703832_-\|hypothetical-protein	gnl\|CDD\|380331	cd20610, Nitro_FMN_reductase_child_20, nitroreductase family protein. Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.	7.56527e-07
NZ_CP022223.1\|WP_014712233.1\|4726447_4726759_+\|DNA-methyltransferase	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.81839e-30
NZ_CP022223.1\|WP_014712227.1\|4716769_4717702_-\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	1.62433e-124
NZ_CP022223.1\|WP_041298262.1\|4704639_4705584_+\|GlxA-family-transcriptional-regulator	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	2.41231e-88
NZ_CP022223.1\|WP_054585282.1\|4718820_4722168_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.82567e-108
NZ_CP022223.1\|WP_042913107.1\|4703851_4704502_-\|HD-domain-containing-protein	gnl\|CDD\|188314	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family. Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.	2.07454e-16
NZ_CP022223.1\|WP_042913109.1\|4711180_4712047_+\|cyclodehydratase	gnl\|CDD\|274832	TIGR03882, hypothetical_protein, bacteriocin biosynthesis cyclodehydratase domain. This model describes a ThiF-like domain of a fusion protein found in clusters associated with the production of TOMMs (thiazole/oxazole-modified microcins), small bacteriocins with characteristic heterocycle modifications. This domain is presumed to act as a cyclodehydratase, as do members of the SagC family modeled by TIGR03603.	0.000510201
NZ_CP022223.1\|WP_009955776.1\|4708639_4709662_-\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	2.9985e-141
NZ_CP022223.1\|WP_042913116.1\|4725659_4726445_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.28646e-16
NZ_CP022223.1\|WP_008259653.1\|4717701_4718772_-\|potassium-channel-family-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	9.10223e-24

>NZ_CP022223.1|WP_042913113.1|4714137_4716258_-|ATP-dependent-DNA-helicase-UvrD2
MDAMPTVADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAAGQVLAVTFTQRAAGEMRSRLRAIDAAAGMGPAVGAVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRARLNASTDEVRDLAGEIEWAKASLIGPEEYPTAVAAAGRDIPLDAAQIAGVYAAYEALKARGEHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDVTPLQQRVLTAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVAGSKLHLVGQRPPGPAPMFHEHPDEPAEAAAVAASIGRLIESGTPPSEIAVLYRVNAQSEIYEEALTEAGIAYQVRGGEGFFNRQEIKQALLALHRASERATARGAEGPLPDVVRAVLEPLGLTAQEPVGTRARERWEALSALAELVDDEVAQRPQLDFPGLLAELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGAESEAVEEERRLLYVGITRARTHLALSWALARSPGGRQGRKPSRFLNGIAPQARAEAGPNKSRRNRATATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLLRLKAWRLDVAKEQKVPAYVVFTDNTLIAIAELRPDDDEALIAIPGIGARKLEQYGPDVLELVRGR
>NZ_CP022223.1|WP_042913111.1|4713481_4713733_-|WhiB-family-transcriptional-regulator
MSAPTAPRPHLPCHAGDPDLWFAEAPADLERAKSLCVDCPVRRQCLAAALERAEPWGVWGGEIFDRGSVLSFKRPRGRPRKAA
>NZ_CP022223.1|WP_008259631.1|4712128_4713472_+|AarF/ABC1/UbiB-kinase-family-protein
MDDGYVADIKRGRAARNAKLASIPVGFAGRAALGFGKRLTGKSRDEVQAELLEKAAHQLFTVLGELKGGAMKVGQALSVLEAAIPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTMQRLVGVFKQLAPGADIQGVVDELIERTEMELDYRLEAENQRAFAKAYHDHPHFAVPRIVASAPKVVIQEWMQGIPMAEIIRHGTTEQRDLVGTRLLELTFDAPRRLEMLHGDAHPGNFMLLDDGRMGVIDFGAVAPLPGGLPIELGMSIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMDLPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAVV
>NZ_CP022223.1|WP_042913109.1|4711180_4712047_+|cyclodehydratase
MTQQCQAALSTYALDPAMPVLLRPDGAVQVGWDPRRAVLVRPPGGLAAAELATLLRTMSSPTPLPELQRRALDRGLTDTEGLRSLVAQLVRAGVATECGRPRGRAPSVRVHGRGPLSELLVESLRCSGARIAHSSQPHAAVSAGDVDLVVLSDYLVADPRMVRDLHDQGVAHLLVRVRDGIGLVGPLVIPGVTSCLGCADLHRRDRDAAWPAICAQLRETVGVADRATVLATAALALSQVNRVIAAVRGQDAASEPEPPQTLNATLEFDLHAGAIVARQWVKHPLCAC
>NZ_CP022223.1|WP_042913108.1|4709786_4711145_+|zinc-dependent-metalloprotease
MADLPFGFSPGEDPDKHGKKDPDSGSNPSDPFAAFGMSGDFGMGDLGQIFTQLGQMFSSAGTVGPGGTASGPVNYELARRVASNSIGFVAPVPDTTNSAIADAVHLAETWLDGATALPAGTAKAVGWTPADWVDNTLETWKRLCDPMAQQISTVWAASLPEEAKSMAGPLLQMMSQMGGMAFGSQLGQALGRLSREVLTSTDIGLPLGPKGIAAIMPDAVESFTTGLERPRSEILTFLAAREAAHHRLFSHVPWLSSQLLGAVEAYAMGMQIDMSGIEELARDFNPASLSDPAAIENLLGQGVFEPKATPAQTQALERLETLLALIEGWVQVVVAAALGDRIPGAGALGETLRRRRASGGPAEQTFATLVGLELRPRKMREAAAFWERLTQAAGVDTRDGIWQHPDLLPNAEDLDEPAGFIDRVIGGDTSGIDEAIAKLEREDPDSDGPVDN
>NZ_CP022223.1|WP_009955776.1|4708639_4709662_-|PDZ-domain-containing-protein
MNRRILTLMVALVPIVVFGVLLAVVTVPFVSLGPGPTFDTLGEVDGKQVVAIQGTLTHPTTGHLNMTTVSQRDDLTLGEALTLWLSDTEQLVPRDIIYPPGKSREEVDKANSADFKQSEDSAEYAALGYLKYPSAVTVAKVPEPGPSAGKLKAGDAIDAVNGTPVATVDAFTGLLKNTKPGQTVTIDYRRKNEPAGVAQITLGSNKDRDYGYLGVAVLDAPWAPFVVDFNLANIGGPSAGLMFSLAVVDKLTTGGLAGSNFIAGTGTITADGKVGQIGGITHKMVAAHAAGATVFLVPAKNCYEASSDNPSGLRLVKVETLSQAVDALHAITSGGQPPSC
>NZ_CP022223.1|WP_026071234.1|4705587_4708566_-|UPF0182-family-protein
MGMRPTARMPKLTRRSRILILIALGVIALLLAGPRLIDAYVDWLWFGELGYRSVFSTVLVTRFVVFLIAGLLVGGIVFAGLAVAYRTRPVFVPSNDNDPVARYRALVLSRLRLVSAGVPVAIGLLAGIIAQSYWVRIQLFLHGGDFGIKDPQFGKDLGFYAFELPFYRLLLSYLFVAVFLAFVANLLAHYIFGGIRLSGRTGALSRSARIQLVTLVGLLVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAGAVFSAVVLRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSIAATRQAYGLTADVVTYRNYTGDAQATAQQVADDRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSIDRYLDRNGSLRDYVVAARELNPDRLIDNQRDWINRHSVYTHGNGFIASPANTVRGIANDPNQNGGYPEFLVNVVGANGNVVSDGPAPLDQPRVYYGPVISNTAADYAIVGRNGADREYDYETSNETKNYTYTGLGGVPLGDWLSRSVFAAKFAERNFLFSNVIGSNSKILFNRDPARRVEAVAPWLTTDSAVYPAIVNKRLVWIIDGYTTLDNYPYSELTSLESATADSNEVAFNRLAPDKRVSYIRNSVKATVDAYDGTVSLYQQDEQDPVLKAWMRVFPGTVKPKSDITPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIAKNDNSSSYQLTSAMNRFKRDYLAAYISASSDPATYGRITVLTIPGQVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVGQGGLLYVEPVYASPGASDAASSYPRLIRVAMMYNDKIGYGPTVRDALTGLFGPGAGAAATGIQPTEAGTPANPPPSAPAPAATPGSPPPAAVPPAPDGSVALSPAKAAVLQEIQAAIGAAKDAQKKGDFAGYGAALQRLDDAITKYNNTK
>NZ_CP022223.1|WP_041298262.1|4704639_4705584_+|GlxA-family-transcriptional-regulator
MVVIVVFDGVTLLDVAGAGEVFVEANRFGADYRLKIASVDGRDVTSSIGTRLGVTDCLSAIDSADIVLVAGSDHLPGRPIDPALVEAVRSVAARTGRMASICTGSFILAQAGLLDGRRATTHWHDARLLARAFRDVTVEPDAIFVRDGDVFTSAGISSGIDLALALVEMDHGTELVRDVARWLVVYLKRAGGQSQFSVLVEADPPPQSPLRAVTEAVAADPGADYSVKKLAALASLSTRQLTRLFQSELGMTPARYVELVRVDFARNALEAGRSVTETAGMAGFGSIETLRRAFVNHLGISPKAYRDRFRTAYA
>NZ_CP022223.1|WP_042913107.1|4703851_4704502_-|HD-domain-containing-protein
MTTSSIDAIAGIHVPDTALAREVTEFIRDTEDELLFNHSRRVYFFGALQGLRRGVQPNLELLYVAAMFHDVGLTEHYRNSTVRFEVDGANAARDFLMDAGADQADADTVWLGIALHTTPGVPEFLAPEVALLQAGVEVDVVGVGREQLAPEALAAVTAAHPRPQFKQRILAAFNDGMKHRPRTTDGTMNADVLAHFDPTFGRVDFVDKILHNSWPE
>NZ_CP022223.1|WP_042913105.1|4703478_4703832_-|hypothetical-protein
MDIYEALYTTRMMRRLRPDPVPLDTQARILDAAVRAPNGANTQRWHELLGVPVEEGWTMSAMLALGYPRGKWGVAANRHPVHEVSSRNGWDKPFGVEVPQPLWPPQDVTASGLAAAS
>NZ_CP022223.1|WP_042913114.1|4716503_4716758_+|mycoredoxin-Mrx1
MTTAPLTVYTTSWCGYCHRLMTVLKSNGIPYEAVDIEHDAAAADFVSSVNGGNRTVPTVKFADGSTLTNPSAAQVKAKLTETGS
>NZ_CP022223.1|WP_014712227.1|4716769_4717702_-|NAD(+)-diphosphatase
MAIADFQLRSVPLLSRVGADRADQLRTDVEAATAGWADAALLRVDSRNQVLVSDGRVVLGAAAELGDKPPSEAVFLGRLEGGRHVWAIRGALQAPEDPDARTEVVNLRSLGPIFDDTSGQLMSSAVALLNWHEKSRFSSVDGSPTRPARAGWSRVNPVTGHEEFPRIDPAVICLVHDGGDRAVLARQAVWPERMFSLLAGFVEAGESFEGCVAREIREEIGLTVRDVRYLGSQPWPFPRSLMVGFHAVGDPAQDFSFNDGEIAEAAWFTRDEVREALAAGDWSSSSESKLLLPGSISIARVIIESWAAID
>NZ_CP022223.1|WP_008259653.1|4717701_4718772_-|potassium-channel-family-protein
MGNGRSRKLSGLDETLTAQRGHQLIGVVRIPEEHASPIRVITRRLAIALVVLFGAAVIVYLDRDGFRDVRNEPLTFLDCLYFSAVSLSTTGYGDITPYTETARLVHTLIFTALRIAFLAVLVGTTLEVLSERSRQGWKIQRWRSRVRNHTIVIGYGTKGKTAVAAILGDETIQAEVVVVDTDRSTLEHAESAGLVTVHGDATKADVLRLAGAQHAASIIVATSRDDTAVLATLTAREIAPNAKIVASIREAENQHLLQQSGADSVVVSSATAGRLLGLATTTPSVVEMIEDLLTPDAGLAIAEREVEQSEVGGSPRHLRDIVLGVVRDGHLWRIDAPEVDAVEANDRLLYIRSVGH
>NZ_CP022223.1|WP_054585282.1|4718820_4722168_-|ATP-dependent-helicase
MNARYNPSELACALGLFPPTEEQSAVIAAPPGPLVVIAGAGAGKTETMAARVVWLIANGYAEPAQVLGLTFTRKAAGQLLRRVRSRLARLAGVGLGPVGDAAAEPEGAPVISTYHAFAGSLLRDYGLLLPVEPDTRLLSETELWQLAFDVVNGYRGELHTDKTPAAVTSMVLRLWGQLAEHLVDTGQLRDTHVELERLVHGLPAGPYQRERGPSQWLLRLLGTQTERAELVPLLDALDERMRAEKVMDFGMQMASAARLAAGFPQVGADLRARYRVVLLDEYQDTGHAQRIALSALFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPRSDGTPAPVLELRTSWRNPPQTLRVANAVSAEARRRSVAVHALRPRPDAPPGTVRCALLPDVVAEREWIADHLDAHYRRARAEGVSPPTAAVLVRRNADAAPIADALRARGIPVEVVGLAGLLSVPEVAEVVAMLRLVADPTAGAAAMRVLTGARWRLGARDIAALWQRARALGGTAADPAPPSPEAIARAADPSHVDADTVCLADAIADPGPAGAYSAAGYQRITALGAELSALRAHLGHPLADLVAEVRRVLGVDCEVRAAAGVAAGWAGTEHLDAFADVVAGYAERADGAATRLDASATASVAGLLGFLDAAETVENGLAPAPLAVARDRVQVLTVHSAKGLEWQVVAVAHLSGGTFPSTASRSTWLTDAAELPPLLRGDRAAAGALGIPVLDTSDVTNRKQLSDKISEHRRQLDQRRVDEERRLLYVAITRAEDTLLVSGHHWGATGVKPRGPSDFLVEIKDVIDRAAVAGDPCGTVEHWAPSPADGERNPLRDNVIEAVWPADPLAVRRDEVERGAALVRRALAAGPGRPCADVDGWAGDVDALLAERARLIEPPVRALPGQLSVSSLVGLARDPAGAAQRLRHRLPSRPDPHALLGNAFHSWVQKFYGAECLFDLGDLPGAADSDVGDSAELAALQTAFTESPWAARTPVAVEAPFEMPIGETLVRGRIDAVFADPDGGATVVDWKTGEPPHGAEALRQAAVQLAVYRMAWAALAGVAESAVRTAFYYVRAGTTVVPDELPSAAELAGLLTDPDGTRCDPRRPSIGEAVPVVT
>NZ_CP022223.1|WP_054585280.1|4722164_4725290_-|ATP-dependent-helicase
MAHTWEADASAVLAPGARGIVRVLGGPGTGKSSLLIDAAVAGIDAGIDPESVLLLTGSGRLGMAERSALTTALLRSRPGRVAVSEPLVRTVHGYAYAVLRRAAERAGDAPPRLVTSAEQDAIIRELLAGDLDDGARATSAWPAQLRPALSTAGFATELRNLLARCAERGIDPGELERLGRHCRRPEWIAAGQFARQYEQVMLLRAAVGTAAPEATTPALGAAELVGAALEAFAVDPELLAAERGRIRVLLVDDAQQLDPQAARLVRVLAAGAELALIAGDPNQAVFGFRGGEPAGLLDGDGPAVTLTTSHRCAPAVARAVSGIAARLPGGGAGRRIDGAGAGEGSVTVRLAASAHAEAAAIADALRRAHLVDGVPWSQMAVIVRSVPRAGARLPRALAAAGVPVAAAAATGPLAEEPAVRALLTVLLAAADGLDGQQALALLTGPIGRVDPVSLRQLRRTLQRANPDRPPGDFAELLVETLSGAVPPGPQFRSLRKVRAVLDAAARCHEAGEDPRYTLWDAWHRSGLQRRWLSVSERGGPAAAQATRDLESVTALFDITDDYVSRTSGASLRGLVEHVAALHLPNANLEPAATAGQVRVLSAHAAMGHEWDFVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTADASMRAPLVAEERRLLVAAMGRARRRLLVTAVDSDTGGADHAAALPSPFFFDIAQWADEDVETTALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDELARDCAATQLARLAKAGVPGADPAGWHGLTPVSTGEPLRGGGDVVTLTPSTLQTLTDCPLRWLAERHGGTNPRDLRSTIGSVVHALIAEPRRSESELLAGLERAWQHLPFAAQWHSDNELARHRAMLEAFVEWRSQSRGALTEVGVEVEIDGTLQTGDGEQVRLRGRVDRLERDAAGRLVIVDVKTGKSPVSKDDAQQHAQLAMYQLAVAEGLVAAGGDTVEPGGARLVYVGKAGAAGAVEREQDPLTADAGDEWRQVIRRAAAATAGPQFVARRNDGCTHCPIRPCCPAHTDGAAR
>NZ_CP022223.1|WP_080691230.1|4725377_4725614_+|hypothetical-protein
MVSRLQKEGLTTMTDEHGFPTDEAPEGDAVEQLRPADSDDDAGLDTDYVSARDREANEADVIEQAYVVSADDERDDDR
>NZ_CP022223.1|WP_042913116.1|4725659_4726445_+|alpha/beta-hydrolase
MTAKLYVHRYGPSGPARILALHGLTGHGQRWQHLSGLLPEIGLAAPDLLGHGRSSWAAPWTIDANVSALAALLDAQAGTPVVVVGHSFGAGLAMHLAAARPNQVSGLLLLDPAIGLDGAWMREIAEAMLSSPDYPDAEEARLEKVHGSWSDVEPALLEAELDEHLVALPNGRYGWRISLPAMMAYWSELARDAVLPPAQTPTILVRAKRTSPPYVTDELIAGLAQRLGSRFRLLDFDCNHMVPYAKPDGVAALARELLGAR
>NZ_CP022223.1|WP_014712233.1|4726447_4726759_+|DNA-methyltransferase
MAPVTDDQVERVRALVAAIPSGRVATYGDIASVAGLSSPRIVGWIMRTDSSDLPWHRVITASGRPARHLTTRQLELLRAEGVLARDGRIALREVRYEFPDGVL
>NZ_CP022223.1|WP_008259667.1|4726765_4727620_-|TIGR02569-family-protein
MTVEPPPDHVLSAFGLAGVKPVYLGASWEGGWRCGEVVLSLVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGTPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWGDVDIFIAADRAAWEERPLASVPPGARVAPATADAERSVELLNQLATLRKPTKSPNQLVHGDLYGTVLFVGTAAPGITDITPYWRPASWAAGVAVIDALSWGEADDGLIERWNALPEWPQMLLRALMFRLAVHALHPRSTAEAFPGLARTAALVRLVL
>NZ_CP022223.1|WP_042913117.1|4727655_4728843_-|adenylyltransferase/sulfurtransferase-MoeZ
MLSVSSLPPLVAPADHLTGDEVARYSRHLIIPGLGVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIVEFDVVEESNLHRQIIHGVADVGRPKAVSARESMLAINPLVDVRLHEVRLDSTNAVELFGCYDLIVDGTDNFATRYLINDAAVLAKKPYVWGSIYQFEGQISVCWEDAPDGRGLNYRDLYPEPPPPGTVPSCAEGGVLGIVCASIASVMSTEVIKLITGIGDSLLGRLMIYDALQMTYRTIAIRRDPSDASRPKITELVDYEQLCGAAADTPVGDATTITPRELRELLDSGKELALIDVREPVEFDIVHIDGAQLVPQSSINSGEGLAKLPRDRMPVLYCKTGVRSAQALAVLKQAGFADAVHLEGGIVAWAQQMQPDMILY

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022223_4	4.1\|3784107\|33\|NZ_CP022223\|CRISPRCasFinder	3784107-3784139	33	NZ_CP022223.1	3784179-3784211	2	0.939

1. spacer 4.1|3784107|33|NZ_CP022223|CRISPRCasFinder matches to position: 3784179-3784211, mismatch: 2, identity: 0.939

gcctcggtggggttgcccttactaggcgtggtg	CRISPR spacer
gcctcggtggggttgcccttactcgccgtggtg	Protospacer
*********************** * *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1736433 : 1815264

Tupanvirus(44.44%)

integrase,transposase

attL 1734307:1734366|attR 1786967:1789093

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1734307:1734366	attL	NA	NA	NA	NA
WP_046182709.1\|1736433_1738899_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909842.1\|1738895_1740119_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_145958864.1\|1741231_1742179_-	hypothetical protein	NA	NA	NA	NA
WP_042911242.1\|1742182_1742425_+	hypothetical protein	NA	NA	NA	NA
WP_157739664.1\|1743990_1744431_-	hypothetical protein	NA	NA	NA	NA
WP_089151531.1\|1745042_1745303_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042911244.1\|1745723_1746311_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_142383138.1\|1746629_1747061_-	hypothetical protein	NA	NA	NA	NA
WP_142383139.1\|1747091_1747469_-	hypothetical protein	NA	NA	NA	NA
WP_087139682.1\|1747431_1748370_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_042911246.1\|1748768_1751768_-	nocobactin polyketide synthase NbtC	NA	NA	NA	NA
WP_042911247.1\|1751764_1753066_-	polyketide synthase	NA	NA	NA	NA
WP_042911248.1\|1753062_1753797_-	thioesterase	NA	NA	NA	NA
WP_087139839.1\|1753793_1754267_-	acetyltransferase	NA	NA	NA	NA
WP_042911250.1\|1754452_1759441_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	1.5e-94	26.7
WP_087139684.1\|1759422_1763901_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	3.1e-35	23.6
WP_042911252.1\|1763924_1767377_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	4.6e-34	23.6
WP_080691156.1\|1767377_1768766_-	SagB/ThcOx family dehydrogenase	NA	NA	NA	NA
WP_069953845.1\|1769063_1770035_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_080691157.1\|1771925_1775966_-	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	1.5e-41	24.6
WP_080691115.1\|1776011_1777178_-	PLP-dependent cysteine synthase family protein	A0A1W6JHY1	Lactococcus_phage	2.6e-34	33.0
WP_051445860.1\|1778321_1779065_-	hypothetical protein	NA	NA	NA	NA
WP_072501249.1\|1779978_1780359_-	DUF4189 domain-containing protein	NA	NA	NA	NA
WP_042909842.1\|1781213_1782437_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_046182709.1\|1782433_1784899_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909843.1\|1784895_1785183_+	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_069953761.1\|1786147_1786960_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.8e-32	33.1
WP_089151532.1\|1787930_1788302_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_089151533.1\|1788315_1789239_+	M56 family metallopeptidase	NA	NA	NA	NA
1786967:1789093	attR	NA	NA	NA	NA
WP_087139686.1\|1789381_1789645_+	hypothetical protein	NA	NA	NA	NA
WP_154074414.1\|1789780_1789930_+	hypothetical protein	NA	NA	NA	NA
WP_139315491.1\|1790133_1790409_-	hypothetical protein	NA	NA	NA	NA
WP_082408970.1\|1790708_1792103_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.2e-48	35.4
WP_080691120.1\|1793235_1794636_-	NADH-quinone oxidoreductase subunit N	NA	NA	NA	NA
WP_042910205.1\|1794657_1796148_-	NADH-quinone oxidoreductase subunit M	NA	NA	NA	NA
WP_089151535.1\|1796151_1797999_-	hypothetical protein	NA	NA	NA	NA
WP_042910207.1\|1797995_1798298_-	NADH-ubiquinone oxidoreductase	NA	NA	NA	NA
WP_042910208.1\|1798294_1798858_-	NADH:ubiquinone oxidoreductase subunit J	NA	NA	NA	NA
WP_042910209.1\|1798861_1799797_-	NADH-quinone oxidoreductase subunit H	NA	NA	NA	NA
WP_089151536.1\|1799789_1800950_-	hypothetical protein	NA	NA	NA	NA
WP_042910211.1\|1800940_1801285_-	NADH-quinone oxidoreductase subunit A	NA	NA	NA	NA
WP_089151537.1\|1802568_1803735_+	PLP-dependent cysteine synthase family protein	A0A1W6JHY1	Lactococcus_phage	1.5e-34	33.0
WP_089151538.1\|1806140_1806440_+	PE family protein	NA	NA	NA	NA
WP_089151539.1\|1806454_1807630_+	PPE family protein	NA	NA	NA	NA
WP_042910215.1\|1807728_1808025_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_042910216.1\|1808033_1808318_+	WXG100 family type VII secretion target	NA	NA	NA	NA
WP_089152393.1\|1808586_1809381_-	DUF1275 domain-containing protein	NA	NA	NA	NA
WP_072501503.1\|1809749_1810772_-	pyridoxal-phosphate dependent enzyme	NA	NA	NA	NA
WP_042910244.1\|1811382_1811589_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_089151540.1\|1811628_1813860_+	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	3.5e-88	34.3
WP_157739665.1\|1813923_1815264_+\|transposase	IS256 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

2370076 : 2405727

Enterobacteria_phage(100.0%)

holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_008256156.1\|2370076_2370415_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_008256158.1\|2370418_2371093_-	phosphoribosyltransferase	NA	NA	NA	NA
WP_008256160.1\|2371725_2373246_-	ATP-binding protein	NA	NA	NA	NA
WP_014711299.1\|2373865_2374678_-	ATP-binding protein	NA	NA	NA	NA
WP_041297812.1\|2374674_2376228_-\|transposase	IS21 family transposase	U5N3F9	Enterobacteria_phage	1.1e-16	27.8
WP_008256161.1\|2376501_2377047_-	hypothetical protein	NA	NA	NA	NA
WP_008256163.1\|2377119_2377329_+	hypothetical protein	NA	NA	NA	NA
WP_014711465.1\|2377481_2378960_-	hypothetical protein	NA	NA	NA	NA
WP_014711466.1\|2378956_2379535_-	hypothetical protein	NA	NA	NA	NA
WP_008256168.1\|2379534_2380020_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_008256169.1\|2380414_2380849_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_008256170.1\|2380852_2381101_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_036428816.1\|2383396_2383975_-	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_008256175.1\|2383971_2385108_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_008256177.1\|2385104_2386574_-	acetyl-CoA acetyltransferase	NA	NA	NA	NA
WP_073916456.1\|2386768_2387332_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_008256182.1\|2387385_2387823_+	PaaI family thioesterase	NA	NA	NA	NA
WP_008256185.1\|2387822_2388734_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_014711468.1\|2388787_2389405_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_036455212.1\|2391683_2392463_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_020822357.1\|2392414_2393023_-\|transposase	transposase	NA	NA	NA	NA
WP_036429555.1\|2396361_2397447_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_014711472.1\|2397474_2398350_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_079628783.1\|2401649_2402456_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_074325745.1\|2402489_2403395_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_095764245.1\|2403576_2403876_-	hypothetical protein	NA	NA	NA	NA
WP_020822362.1\|2404375_2404675_-	hypothetical protein	NA	NA	NA	NA
WP_020822364.1\|2405427_2405727_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_3

4440382 : 4446958

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042912786.1\|4440382_4442548_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	3.3e-208	51.6
WP_008259183.1\|4442517_4442970_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	5.8e-14	40.2
WP_008259184.1\|4443001_4443241_-	redoxin NrdH	V5UN81	Mycobacterium_phage	1.3e-20	63.2
WP_008259185.1\|4443769_4444324_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.2e-05	34.4
WP_008259186.1\|4444415_4445030_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_008259187.1\|4445038_4446082_+	DNA polymerase IV	F1C5A5	Cronobacter_phage	3.9e-21	29.1
WP_008259188.1\|4446016_4446958_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.2e-05	28.8

DBSCAN-SWA_4

5006455 : 5016494

Burkholderia_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_036453838.1\|5006455_5007982_+	cyclic nucleotide-binding domain-containing protein	W8CYF6	Bacillus_phage	1.3e-12	37.4
WP_036453840.1\|5008021_5008870_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_036453842.1\|5008890_5009757_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_008260499.1\|5009784_5010780_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	5.8e-75	46.5
WP_036455274.1\|5010781_5011399_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.6e-27	38.8
WP_036453844.1\|5011639_5012764_+	acyltransferase	A9YX16	Burkholderia_phage	1.4e-16	28.6
WP_036453846.1\|5012908_5014045_+	acyltransferase	A9YX16	Burkholderia_phage	2.3e-19	30.5
WP_036453848.1\|5014140_5015307_+	acyltransferase	A9YX16	Burkholderia_phage	1.0e-17	25.4
WP_036453849.1\|5015405_5016494_+	acyltransferase	A9YX16	Burkholderia_phage	6.1e-17	29.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022223

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection