CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022961	Plantactinospora sp. KBS50 chromosome, complete genome	30 crisprs	csa3,cas3,DEDDh,RT,cas4,WYL,csm3gr7,csx19,cas6,cas7,cas5,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	4	36	4	0

1. NZ_CP022961

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022961_1

• CRISPR_ID: NZ_CP022961_1
• CRISPR_location: 139249-139355
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_1

Consensus_repeat	Method
CGCCGGCCGGCCGTAGACGCCGGG	CRISPRCasFinder

spacers of NZ_CP022961_1

>1.1|139273|59|NZ_CP022961|CRISPRCasFinder
CGTGCGCTGTTCGGGGGGCCGGCCTGGGCGGCGTCCTCGTCGGGCTCCGCTTCGGCCGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_1

CRISPR arrays

The CRISPR arrays of NZ_CP022961_1

>merge|NZ_CP022961|1|139249-139355|CRISPRCasFinder
CGCCGGCCGGCCGTAGACGCCGGGCGTGCGCTGTTCGGGGGGCCGGCCTGGGCGGCGTCCTCGTCGGGCTCCGCTTCGGCCGGCGCCGGCCGGCCGTAGACCCGGGG

>NZ_CP022961|1|1|139249-139355|CRISPRCasFinder
CGCCGGCCGGCCGTAGACGCCGGG	CGTGCGCTGTTCGGGGGGCCGGCCTGGGCGGCGTCCTCGTCGGGCTCCGCTTCGGCCGG
CGCCGGCCGGCCGTAGACCCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095567457.1|134519_135197_-|hemolysin-III-family-protein	unknown	unknown	gnl|CDD|273425
NZ_CP022961.1|WP_157756552.1|138015_138828_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP022961.1|WP_095563171.1|142911_143901_-|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|223101
NZ_CP022961.1|WP_095563173.1|145703_146666_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP022961.1|WP_095563176.1|151860_153750_+|molecular-chaperone-DnaK	unknown	unknown	gnl|CDD|234715
NZ_CP022961.1|WP_095563166.1|133126_133396_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563169.1|135312_136065_+|LamB/YcsF-family-protein	unknown	unknown	gnl|CDD|377121
NZ_CP022961.1|WP_095563170.1|136071_137904_-|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|271321
NZ_CP022961.1|WP_095563172.1|143900_145082_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl|CDD|213783
NZ_CP022961.1|WP_095567458.1|141475_142906_-|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl|CDD|237001
NZ_CP022961.1|WP_157756555.1|149787_151611_-|ABC-transporter	unknown	unknown	gnl|CDD|206648
NZ_CP022961.1|WP_095563177.1|153787_154594_+|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl|CDD|184546
NZ_CP022961.1|WP_095563165.1|131084_132938_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173842
NZ_CP022961.1|WP_095563167.1|133436_134006_-|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|224973
NZ_CP022961.1|WP_095563175.1|148087_149779_-|ABC-transporter	unknown	unknown	gnl|CDD|206743
NZ_CP022961.1|WP_157756554.1|147941_148091_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563164.1|129800_130928_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP022961.1|WP_095563168.1|134123_134402_+|hypothetical-protein	unknown	unknown	gnl|CDD|374019
NZ_CP022961.1|WP_095563163.1|129068_129701_+|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl|CDD|223868
NZ_CP022961.1|WP_095563174.1|146714_147932_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095567457.1|134519_135197_-|hemolysin-III-family-protein	gnl|CDD|273425	TIGR01065, Hypothetical_UPF0073_protein_yqfA., channel protein, hemolysin III family. This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.	1.32776e-55
NZ_CP022961.1|WP_157756552.1|138015_138828_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.000166955
NZ_CP022961.1|WP_095563163.1|129068_129701_+|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl|CDD|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	1.21058e-32
NZ_CP022961.1|WP_095563173.1|145703_146666_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.00051125
NZ_CP022961.1|WP_095563169.1|135312_136065_+|LamB/YcsF-family-protein	gnl|CDD|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	7.03498e-132
NZ_CP022961.1|WP_095563168.1|134123_134402_+|hypothetical-protein	gnl|CDD|374019	pfam15686, LYRIC, Lysine-rich CEACAM1 co-isolated protein family. LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumor cell migration and invasion by activating the transcription factor NF-kappaB.	0.000539231
NZ_CP022961.1|WP_095563170.1|136071_137904_-|redoxin-domain-containing-protein	gnl|CDD|271321	cd14951, NHL-2_like, NHL repeat domain of NHL repeat-containing protein 2 and similar proteins. NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	2.07091e-140
NZ_CP022961.1|WP_095563172.1|143900_145082_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl|CDD|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	7.49071e-169
NZ_CP022961.1|WP_095567458.1|141475_142906_-|2-oxo-acid-dehydrogenase-subunit-E2	gnl|CDD|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.54748e-154
NZ_CP022961.1|WP_157756555.1|149787_151611_-|ABC-transporter	gnl|CDD|206648	cd00882, Ras_like_GTPase, Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases). Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.	4.01264e-08
NZ_CP022961.1|WP_095563177.1|153787_154594_+|nucleotide-exchange-factor-GrpE	gnl|CDD|184546	PRK14163, PRK14163, heat shock protein GrpE; Provisional.	9.58974e-41
NZ_CP022961.1|WP_095563165.1|131084_132938_+|acyl-CoA-dehydrogenase	gnl|CDD|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.20856e-178
NZ_CP022961.1|WP_095563167.1|133436_134006_-|histidine-phosphatase-family-protein	gnl|CDD|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.08633e-34
NZ_CP022961.1|WP_095563176.1|151860_153750_+|molecular-chaperone-DnaK	gnl|CDD|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP022961.1|WP_095563164.1|129800_130928_+|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.71161e-32
NZ_CP022961.1|WP_095563175.1|148087_149779_-|ABC-transporter	gnl|CDD|206743	cd11383, YfjP, YfjP GTPase. The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.	3.42703e-28
NZ_CP022961.1|WP_095563171.1|142911_143901_-|alpha-ketoacid-dehydrogenase-subunit-beta	gnl|CDD|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.14429e-152

Protein sequences

>NZ_CP022961.1|WP_157756552.1|138015_138828_-|hypothetical-protein
MGPAFPDDPSFSGGPRDRGEQRNDPMNGAAFGAPPDAAGRGPGGDARPGFGPDPARGFGAGPPAGPGFGPNNGGPNNGGGPNAAFAGPAPARFPGPGSGPGAGPNAGPGGGVGGPPGGAPHGAPGVYGARPGVPGSTTEDDPDQQRFNSFKPEEPAEAAKEEPPAPPPQVRNGRVLAAVLAAAVLLLVIPLGAVWLFSGGGKDTYNPAVGDCVKQAGSAPAKATCGEAGSYKVTAKQASTEQCPDANQPHLVVKESDGSEQVLCLEPAAS
>NZ_CP022961.1|WP_095563170.1|136071_137904_-|redoxin-domain-containing-protein
MSTTPRVRAPELRGRAWLNTGGQELKLADLKGRITILDFWTFCCINCLHVLDELRPLEEKYGDVLVVIGVHSPKFEHEKDPAALAAAVERYGVAHPVLDDSELITWQQYAAKAWPTLSVIDPEGYVVATMAGEGHVEGLTRLVDDLVATHEARGTLRRGDGPYVPPAEPTTALRFPGKAVALPGGSLLVSDSARHSLVELAADGETAVRRIGSGQRGRADGDPAAASFAEPQGMVLLPPHAAEIAGYDVVVADTVNHLLRGVRLATGEVSTVAGTGRQWRSTVDDHAHDALSIDLSSPWDLAWYDGRVIVAMAGIHQLWWFDPVRRTTGVFAGTTVEALRDGPLPDVWLAQPSGLSTATDGSRLWIADSETSALRYVADGVLHTAVGQGLFDFGHVDGPAEGALLQHPLGVAALPDGSVLVADTYNGAVRRYDPATGLVSTVASGLAEPSDVLPTPDGGVLVVESAAHRLTGLAPGALAAAGARVQGSRHRAERPPTEVAAGAVTLDVVFTPAPGQKLDTSFGPSTRLVVSASPPELLLDGAGTGTELSRQLVVNPDVPSGVLQVVAQAATCDAEAEHAACHLSRQDWGVPVRVVAVGPTRLPLVLRGLD
>NZ_CP022961.1|WP_095563169.1|135312_136065_+|LamB/YcsF-family-protein
MDLNADLGEGFGTWRLGDDDALLDTITSANVACGFHAGDAPTMRRVCAAAADRNVAVGAQVGYRDLAGFGRRRIEYAYDELRDEIVYQIGALAAFCRLAGTTLRYVKPHGALYNTAAVEECQAAAVVAAVGEYDSTLPILCQPGTVLAQLATGAGLRAVAEGFADRGYRPDGTLVPRTAPDALVTGASEVVERAVRMARDGVVTARDGSQVPAAVQSICVHGDTPGAVDLARRIRSALTEAGLPLRPFTG
>NZ_CP022961.1|WP_095567457.1|134519_135197_-|hemolysin-III-family-protein
MTTSAPFRMKPVDIGKPRLRGWLHTYAFFVAIACGIVLCSLAAARPGWTALVSCAIYSLTVCGLFGTSALYHRRVWSERGFQVMRRLDHSMIFIFIAGTYTPFCLLLLGEHAATVLLSLVWTGALAGVAVKLVWPHAPRWVSAPLYIALGWVAVAVLPDILRNGGVTALVLMLVGGLVYSVGAVFYALRRPNPWPTVFGHHEFFHACTLVAAICHHIAIYFAIFA
>NZ_CP022961.1|WP_095563168.1|134123_134402_+|hypothetical-protein
MGIGGSIFLIALGAILTFAVDADLGFINIHVVGWVLMLAGVVGLILTLWFWQSRRRTVVRDTPVVRETPAVPGQDTRVEEYREVRRPSPPPV
>NZ_CP022961.1|WP_095563167.1|133436_134006_-|histidine-phosphatase-family-protein
MTTRTIVLLRHAKADRPGRVADDERALTAGGHADAAAAGAWLEHSGYRPQEVICSPAKRTRQTWQDVALGMTAPHPGEHTGDAGTSGRRPLDPPAVPGLGPVVRYEEQVYGGQAGDLLDLVRQAGEAVSTVLLVGHNPAVSELSELLDPIHADPDGLRTCGIAVHRFDGNWPELAPGGAPLERWHTARG
>NZ_CP022961.1|WP_095563166.1|133126_133396_+|hypothetical-protein
MGIGSGILLIAIGAILTFAVRANVWWIDLRAVGWVSMLAGIAVLLITLSYWHTRRQRARTLIVEENRLSHPTAMMPPPPDPPPPNAPPS
>NZ_CP022961.1|WP_095563165.1|131084_132938_+|acyl-CoA-dehydrogenase
MTHYKSNLRDIEFNLFEVFGVDRTFGSEPYADLDSDTARSILAEVDRLAREDLAASYTDSDRNPPVFDAATHSAPLPESFKRSFRTFMDSEFWRLDLPAELGGTGAPRALWWGLGEMILGANAPIWMYASGPSFAHVLHVEGTPEQRKWAKLFIDRQWGSTMVLTEPDAGSDVGAGRTRAIPQPDGSWHIEGVKRFITSGEHDLSDNIVHYVLARPVGVEGVGGPGTKGLSLFVVPKYHFDAETGELGERNGVYATNVEHKMGLKVSNTCELTFGEHGTPAQGWLLGDRHDGIRQMFMIIEYARMMVGTKAIATLSTGYLNALEYARNRVQGADLTQMADKTAPRVAITRHPDVRRSLMMQKSYAEGLRALVCYTATWQDRINVAEASGDEKTARLAKRVNDLLLPLVKGVGSERAYELLGHESLQTFGGSGFLQDYPLEQYVRDAKIDTLYEGTTAIQSLDLFFRKIVKDGGKALLTVAGEIQAFIESEGGNGQLKEERQALGKALAEVQTMVGTMTTWLGEAQDDPRALYKVGLTSRRLLLAVGDLVVGWLLQRQAQVALEALGAEVSGRDKPFYEGKVAAARFFAHEVLPRIGADRRIVESTSLDLMDLSDDAF
>NZ_CP022961.1|WP_095563164.1|129800_130928_+|serine/threonine-protein-phosphatase
MLFGVHTHPARPFRRSLSPGSRVGLGAALVLLAVICAIELIDRSTTSYLGLVVAVPFLAAAFAAWRVVLGVGVLATVAGMSFALAGRMLTTDVVVNVLGIALATGLAAVVSLVRQRQAEQIDELSKLASVAQQAVLRPLGPQVGALAVAGHYISSTAAADIGGDLYEALDTPYGVRMIIGDVRGKGLDAVRLASIVLGSYRHVAYERADLRAVVADLDRAVARSVGDEDFVTAALVEERGGTLTIVNCGHPAPLLLRRGAVIPLEPPAPAPPLGFVPAVQPRVERLEPGDRLLLFTDGLGEARRDGEFFPTADRAWRLLGHGTVADGLASLETALVEWVRGRLEDDIALVLMEYGGTDQSSATAVPSWEVGAAEN
>NZ_CP022961.1|WP_095563163.1|129068_129701_+|septal-ring-lytic-transglycosylase-RlpA-family-protein
MVGRHSRTGFFRSPVGIVSSAAVGVALAVGGTVGAVHLAAQPASVADVAEPAATTWSPEALPSTVTPSSSAPTPSPSAGSASPTSSRASQPASRSKARTASPTPSATAQKSATPTVVSSGTCGASFYDEGQMTANGETFDPDALTAAHKTLPFDTRVRVTNPATGKSVTVRINDRGPYIDGRCLDLSRAAFADIASLSQGEVTVKYEVLK
>NZ_CP022961.1|WP_095567458.1|141475_142906_-|2-oxo-acid-dehydrogenase-subunit-E2
MSRIKEFPLPDLGEGLTEGEILKWMVSVGDTIELNQPIVEVETAKAAVEIPAKWAGQVHAIFQDEGATVEVGTPIIAIDTQPGAGPVPEATTTGQPGSELPTPSAASLAAVQIAPAEGAIEPGMVGSPAPARTPVLVGYGPRTAAAKRRPRKAAPGTPTAAPAATPAPAPAAPQGRNGAVVLAKPPVRRLARDLGVDLGALAGSGPLGSITREDVQRAADGEPGAAATAPAPSRPAGSAPSFGADREQRIPVKGVRKLTAENMARSAFTAPHVTEFLTVDVTRSMRALDRLRARRDWRDVRVSPLLLVAKAVLLAVRRHPMVNSAWAGDEIVVKEYVNLGIAAATERGLIVPNIKDAGRLSLRELADAMTGLVQTAKSGRTAPADMAGGTLTITNVGVFGVDTGTPILPPGESAILAFGAVREMPWVHKGKVKPRQVTTLGLSFDHRIIDGELGSRFLADIGAFLADPEASLLAWT
>NZ_CP022961.1|WP_095563171.1|142911_143901_-|alpha-ketoacid-dehydrogenase-subunit-beta
MATETLTVGKALNTGLRRALESDPKVVIMGEDVGKLGGVFRITDGLQKDFGDQRVIDTPLAESGIIGTAVGLAIRGYRPVCEIQFDGFVYPAYDQIVSQVAKLHYRSQGKVRIPMVIRIPYGGGIGAVEHHSESPEAYFAHTAGLKVVTCANPQDAYSMIQQAVASDDPIVFLEPKRRYWEKGPVDLDAPLSGAYPLHAARVVRPGTDATVLAYGPMVRVALDAATAAAEDGRELEVVDLRTLSPLDLGAVYESVRRTGRCVVVHEAPGNLGLGSEIAARITEECFYSLEAPVLRVTGYDTPYPASRVEEEYLPDLDRVLDAVDRTFGW
>NZ_CP022961.1|WP_095563172.1|143900_145082_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MAKGDPGVTARGKRAPSRSKRPAAGQPSSEPVQLLTPEGDRVDSVVGQDGVEYRVDFTDAEYRSLYRDLVLVRKLDAEATALQRQGELGLWASLLGQEAAQVGSGRALRSQDMAFPTYREHGVLYCRGIDPIMPLGLFRGVDQGGWDPNEFKFNMYTIVIGAQTLHATGYAMGVTMDGKTGSEDGEAVIAYFGDGATSQGDVNEAFVWAGVFNAPLVFFCQNNQYAISEPLERQTRIPLYQRAAGFGFPGVRVDGNDVLASYAVTRHALDNARLGQGPALIEAYTYRMGAHTTSDDPTRYRIASEVEAWQAKDPIARMRAFLTRQQLADDAFFAEVDEQARREAVHLRERVLEMPNPEPVSMFDHVYPHGSAELDTQREGLSRYLESFEGSVH
>NZ_CP022961.1|WP_095563173.1|145703_146666_-|hypothetical-protein
MVPTLGTGPAAGVGIGVGVGVGVGPTVGVGPTVGDDPTVGDDPTVADGAGATVGVCPTDGDGDAVGPAVGPAVGPAVAVGSQVAVGPTVGVGAGPVGTAVAVGVGPPVGATVALGPAVGVGSGAAVAVGSAVPVGPGSAVPLGSGVGDADGVGVPVGDPPGVGSGPPVGVGSGVPPGGGTVGAGTVGAGVPGAGTVGAGTLGDGPGGPPGGSGGEVDTGPPGGGTGAPGPRDGLGSVGPRRPEPAEGVTRSPSPVHGGGSPGSLVGGSGMTTTGPSDSGATNGGSSAAAPPVLRTVAEPALITARIGSDAVPASIATVSR
>NZ_CP022961.1|WP_095563174.1|146714_147932_-|hypothetical-protein
MATPQTPYEAVLHAARDVTRLDSALDAEMLGTALLGSVYALAEEDRSAAVRRFVGDFLAATTRRRSAAATTIRRIFAVLVPDASGAGTVKPGAQAPPWSGELGRVRLTGSYAYGDVYGDQTSYLATFAYGDTEVGGPEHAVVALVDHNIGITKDVFVGGPAAGILDQVKQMCAGDDLTWFRPEDPVRLRAEVSRHLAITDGLSELPDEGSLATDRALVGARLALLPAPPLTAVPEPEPLSADERGRLVREFLASPEARRHRLDEVDGADLASLHFCLSLVLDHASTLPEPDPMRWSPAVAGLFLLDWVHRRAVLDMDDAAMLPRVVRAWATYALRRRGLPEQAVTQTDGAIEDMVPEFVRLYTTGERRSPATAAVAQLMADGVDPNDPDALEAWIEANRQRLGDD
>NZ_CP022961.1|WP_157756554.1|147941_148091_-|hypothetical-protein
MIPSPAHLVFHRIRPGPLGHGDPRTGRLAPALGVAIPAALLVLSARSPA
>NZ_CP022961.1|WP_095563175.1|148087_149779_-|ABC-transporter
MGRFRDALTGDRRIDPDVLLDRVAAVRRFLDLVEGHLPDERLGPAHTLVERAGDRLALSRDHTVVALAGATGSGKSSLFNALARIDLSPVGVRRPTTGVTYACVWGAPDGAGRLLDWLGVLPRNRFVRESALDAEDEAGLRGLVLLDLPDFDSVQHAHRREVDRLLGLVDLVVWVVDPQKYADRVVHESYLREFHRHRDVTVVVLNQTDLLPPADVQRVLADLRRLLDDDGLSGVPVLATSAVDPAALTDLHAALQTTVGERQAALRRLSGDADAVLDELAPMMDASSPPDDLDRTSLPRLTDALAGVAGVSAVVEATEKAYRHRAAGSTGWPLVRGWRRLRPDPLRRLHLPGPASGAGAGATEPAVEHPIPATSVPDPTAAQRSAVGLAVRRVADRAGHGLPEPWPDAVAAAARSRLADLPDALDGAIGSTDLGLRRKPVWWRLVSGVQWLVTLAAAGGLGWLIVGYAVRALGLPPLEYPMIGQVPLPTLLLLAGLLAGLLLGLLARPLITLGARRARRRAQRRLRAAVSVVADGYVIKPVRAVRTAYEQAREALLAARSAR
>NZ_CP022961.1|WP_157756555.1|149787_151611_-|ABC-transporter
MTTQGEPAGPSTALPPTQPAPRSASKTPGQAEPDLPAALGELRAAAEGVTFPLVLPSAQEATRSIRSLVGQLDDYLLPRLARLDAPLLVVVGGSTGAGKSTLVNSLVRARVSASGVLRPTTRAPVLVCSPADSTWFRQGDLLPGLTRTNQPGTDPHTLQLVAAPALTPGLAFLDAPDIDSVVDANRALAAQLLAAADLWLFVTTAARYADAVPWELLRTARERGTVIALVLDRVPAAAADEIAQHLAEMLAEHDLGTAPLFVLPETTVDGQGLLPERAVGGLRGWFDQLAADGQARGAVVRQTLDGALAALGPAVGRIAAGADDQSRAAATLDERVAAAYRQARRTVEQGVRDGRLLRGEVLARWQEFVGTGELFRTLEARIGRLRDRVVAAVTGRPAPGRELQTAIESQLVTLLCGVAADAAEAAYTGWQAHPAGAGLLDPSLARPAADFPDRAERLVREWQRGVLELVRTEGGDRRFIARTAAYAVNAMGLAVTIAVFASTAFIPTGLEVATGAGTTVAGQVVLQAIFGDQAVRNLAARARVELLNRAAELLDAEAQRFHGRTAAAGVDGAAAQRLRTAAADVERARQHAGLTTDAPLTLPGDDR
>NZ_CP022961.1|WP_095563176.1|151860_153750_+|molecular-chaperone-DnaK
MARAVGIDLGTTNSCVSVLEGGEPTVIANAEGSRTTPSIVAFARNGEVLVGEVAKRQAVTNPDRTIRSVKREIGTNWTVDIDGKKYTPQEISARTLMKIKRDAEAYLGEQITDAVITVPAYFNDAQRQATKEAGEIAGFNVLRIVNEPTAAALAYGLDKGSKEQTVLVFDLGGGTFDVSLLELAEGVIEVKSTSGDNHLGGDDWDQRIIDHLVKTFRGEQGIDLSQDKMAMQRLREAAEKAKIELSAATTTNINLPYITAGQAGPLHLDVTLSRAEFQRMSQDLLDRCKGPFEQAIKDAGIKVADVDHVILVGGSTRMPAVTDLVKQLTGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGIFTKLIERNTTIPTKRSEVFTTADDNQPSVLIQVFQGEREIAAYNKKLGTFELTGLPPAPRGVPQIEVAFDIDANGIVHVHAKDLGTGKEQSMTITGGSALPKDDIERMMRDAQDHADDDKRRREEAETRNLAEQLQWQTEKFLAESGDKLPAENRDQINEALGDLRGALGGSDLEKIKSAHEKLAEVSQQAGSLLYAQQQADAGQQGGPDAAGAAGAGAGAGAGASGGAGQSAGADDVVDAEIVDEDDKK
>NZ_CP022961.1|WP_095563177.1|153787_154594_+|nucleotide-exchange-factor-GrpE
MTNKPRNAEAGSAGPAPGGSAQAGPDKSDGERVVVRDKRRIDASGGKGEPTEPPAGDDAAGTGTDAESAGIKPQTSTEAELAGESAERAADAEAEAGASTGGDKPVVDAPAEPVEEPADRSGPLGAELAALRSDLDERTRDVQRVSAEYANYRKRVDRDRGLVAEQTTGNVLTALLPILDDLDRAREHGDLVGPFGAVAEQLGAALGKFGLTAFGEKGDPFDPTRHEAVAHRTSSEVTEPTCVEVMRRGYQLGERLLRPALVAVADPE

Crispr_ID: NZ_CP022961_2

• CRISPR_ID: NZ_CP022961_2
• CRISPR_location: 210979-211086
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_CP022961_2

Consensus_repeat	Method
CGTAGCCTACTGACGAGTAGGTTC	CRISPRCasFinder

spacers of NZ_CP022961_2

>2.1|211003|60|NZ_CP022961|CRISPRCasFinder
GATGCAAGCCCCGCGTCGCGAATCCGGCCCGGGTCGTCCTGTTCCCGACCCGGATGGTGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_2

CRISPR arrays

The CRISPR arrays of NZ_CP022961_2

>merge|NZ_CP022961|2|210979-211086|CRISPRCasFinder
CGTAGCCTACTGACGAGTAGGTTCGATGCAAGCCCCGCGTCGCGAATCCGGCCCGGGTCGTCCTGTTCCCGACCCGGATGGTGGCGTAGCCTACTGACGAGTAGGTTC

>NZ_CP022961|2|2|210979-211086|CRISPRCasFinder
CGTAGCCTACTGACGAGTAGGTTC	GATGCAAGCCCCGCGTCGCGAATCCGGCCCGGGTCGTCCTGTTCCCGACCCGGATGGTGG
CGTAGCCTACTGACGAGTAGGTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095563219.1|216621_217962_+|MFS-transporter	unknown	unknown	gnl|CDD|340863
NZ_CP022961.1|WP_095563210.1|206210_207425_-|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173847
NZ_CP022961.1|WP_095563211.1|207426_207879_-|SCP2-sterol-binding-domain-containing-protein	unknown	unknown	gnl|CDD|376720
NZ_CP022961.1|WP_095563224.1|224222_224981_+|hypothetical-protein	unknown	unknown	gnl|CDD|377205
NZ_CP022961.1|WP_095563216.1|212447_213347_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP022961.1|WP_095563215.1|211135_212428_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|236440
NZ_CP022961.1|WP_095563206.1|199351_200404_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP022961.1|WP_095563212.1|207940_208603_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP022961.1|WP_095567465.1|202634_204539_+|alkaline-phosphatase	unknown	unknown	gnl|CDD|224699
NZ_CP022961.1|WP_095563207.1|200528_201632_+|arabinogalactan-endo-1,4-beta-galactosidase	unknown	unknown	gnl|CDD|311610
NZ_CP022961.1|WP_095563213.1|208608_209478_-|hypothetical-protein	unknown	unknown	gnl|CDD|239531
NZ_CP022961.1|WP_095563221.1|219542_220058_-|YbjQ-family-protein	unknown	unknown	gnl|CDD|376657
NZ_CP022961.1|WP_095563223.1|220606_221290_+|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	unknown	unknown	gnl|CDD|235140
NZ_CP022961.1|WP_095563214.1|209525_210974_-|3-oxoacyl-ACP-reductase	unknown	unknown	gnl|CDD|236207
NZ_CP022961.1|WP_095563220.1|218036_219461_+|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|176471
NZ_CP022961.1|WP_095563208.1|201870_202461_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP022961.1|WP_095563217.1|213429_215784_-|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815
NZ_CP022961.1|WP_095563209.1|204608_206177_-|AMP-binding-protein	unknown	unknown	gnl|CDD|236097
NZ_CP022961.1|WP_095563222.1|220349_220610_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl|CDD|235659
NZ_CP022961.1|WP_095563218.1|216052_216622_+|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|378968

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022961.1|WP_095563218.1|216052_216622_+|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.2e-11	39.7	1.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095563219.1|216621_217962_+|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.91979e-53
NZ_CP022961.1|WP_095563210.1|206210_207425_-|acyl-CoA-dehydrogenase	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	4.93182e-118
NZ_CP022961.1|WP_095563211.1|207426_207879_-|SCP2-sterol-binding-domain-containing-protein	gnl|CDD|376720	pfam02036, SCP2, SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C-terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.	2.50659e-12
NZ_CP022961.1|WP_095563224.1|224222_224981_+|hypothetical-protein	gnl|CDD|377205	pfam04029, 2-ph_phosp, 2-phosphosulpholactate phosphatase. Thought to catalyze 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor. Involved in the second step of coenzyme M biosynthesis. Inhibited by vanadate in Methanococcus jannaschii. Also known as the ComB family.	1.35857e-17
NZ_CP022961.1|WP_095563216.1|212447_213347_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.28067e-12
NZ_CP022961.1|WP_095563215.1|211135_212428_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|236440	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase.	0
NZ_CP022961.1|WP_095563206.1|199351_200404_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	5.97996e-109
NZ_CP022961.1|WP_095563212.1|207940_208603_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.81008e-12
NZ_CP022961.1|WP_095567465.1|202634_204539_+|alkaline-phosphatase	gnl|CDD|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	1.07256e-99
NZ_CP022961.1|WP_095563207.1|200528_201632_+|arabinogalactan-endo-1,4-beta-galactosidase	gnl|CDD|311610	pfam07745, Glyco_hydro_53, Glycosyl hydrolase family 53. This domain belongs to family 53 of the glycosyl hydrolase classification. These enzymes are enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known and has a TIM barrel fold.	3.67833e-111
NZ_CP022961.1|WP_095563213.1|208608_209478_-|hypothetical-protein	gnl|CDD|239531	cd03447, FAS_MaoC, FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).	1.94891e-12
NZ_CP022961.1|WP_095563221.1|219542_220058_-|YbjQ-family-protein	gnl|CDD|376657	pfam01906, YbjQ_1, Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerizes as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	1.66029e-32
NZ_CP022961.1|WP_095563223.1|220606_221290_+|phosphoribosylformylglycinamidine-synthase-subunit-PurQ	gnl|CDD|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	3.78211e-134
NZ_CP022961.1|WP_095563214.1|209525_210974_-|3-oxoacyl-ACP-reductase	gnl|CDD|236207	PRK08261, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	0
NZ_CP022961.1|WP_095563220.1|218036_219461_+|adenylosuccinate-lyase	gnl|CDD|176471	cd03302, Adenylsuccinate_lyase_2, Adenylsuccinate lyase (ASL)_subgroup 2. This subgroup contains mainly eukaryotic proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP). ASL deficiency has been linked to several pathologies including psychomotor retardation with autistic features, epilepsy and muscle wasting.	1.27325e-178
NZ_CP022961.1|WP_095563208.1|201870_202461_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.55689e-13
NZ_CP022961.1|WP_095563217.1|213429_215784_-|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	2.12218e-116
NZ_CP022961.1|WP_095563209.1|204608_206177_-|AMP-binding-protein	gnl|CDD|236097	PRK07788, PRK07788, acyl-CoA synthetase; Validated.	0
NZ_CP022961.1|WP_095563222.1|220349_220610_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl|CDD|235659	PRK05974, PRK05974, phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed.	1.56702e-31
NZ_CP022961.1|WP_095563218.1|216052_216622_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	1.12045e-12

Protein sequences

>NZ_CP022961.1|WP_095563214.1|209525_210974_-|3-oxoacyl-ACP-reductase
MTDRYASFANSGPGRAFVKRLGLPDPPRLRRYRPGDPLLPAPALLGAAAGGRLHDSVGKLLAAAGVAVREPATATTDATTTEADAEAIATDAAGTGTGTGAEAEAEAAAGTERYAALVFDATGITDSTGLRALYDFFHPYARRLVPSGRVIVLGTPPDVAANPREATAQRALEGLTRSIGKEFGRGTTSQLVYVDQDADPVSLESTLRFLLSGRSAYVSGQVVRVGPGAGSAPQDWDRPLADRVALVTGAARGIGAELARVLARDGARVIALDIPAAGDELAQVANAIGGEAVQLDLTGADAPERLARYVADRHGQLDVLVHNAGITRDKTLGRMDPARWDAVLDVNLSSQERINDVLLDRDLIRAGGRLIGVSSIAGIAGNRGQTNYATSKAGVIGLVRSLAPVLAERQITVNAVAPGFIETRLTARIPMMLREAGRRMNSMAQGGLPVDVAETIAWFASPASGGVTGNVVRVCGQSLLGA
>NZ_CP022961.1|WP_095563213.1|208608_209478_-|hypothetical-protein
MSTLELPRMPAAGPLYRRAALALVPGVGARRAGELPDIELLVRDVAVDRERLADYDRVCGFPLSDRLPATYPHIMAFPLALRLMTAPDFPFPMVGLVHVANRITVHRPLDAGERFDLSVRAADLRPHDRGRQLDVVATASVAGAAVWEDVSTYLSRERAPERGDRGDRRDRGDRPAPPPAGARWRVQPRVGTGYARVSGDHNPIHTWRIGARLLGFPRPIAHGMWSKARCLAALAGRLPDAYTVDVAFKLPLPLPSTVAFSASPVDGGGWTFALHNASSGKPHLAGSLR
>NZ_CP022961.1|WP_095563212.1|207940_208603_+|TetR/AcrR-family-transcriptional-regulator
MLARVATSFKRLPRAVREQQMLDAAVKVFSRRGYHAASMDEIAEDAGISKPMVYAYLGAKDKLFTACLYREGTRLMEAIAAAVEPDLPADEQLWRGLRAFFRFVGAHRDGWAVLYRQARGEQPFAEQLAAMRTRMVEVVTGMLHRALAAQGREVRPNELEIMAYALVGASESVADWLADHPEADPEWAATRVMSVSWLGAGQLLDGHRWLPDAARSGADG
>NZ_CP022961.1|WP_095563211.1|207426_207879_-|SCP2-sterol-binding-domain-containing-protein
MTDFDPAAFASVGPKEFAQLVKSIPDAKIAEVMASDARGKVLDEVFSRMPALFRADRAGSTNAVIHWNITGRPDGGADTYEVVIADGACTASNTPEHDPRLSLTLGPLEFLKIVSGGANPVMMFMTGKLKAKGDLGLAANIANLFDIPKA
>NZ_CP022961.1|WP_095563210.1|206210_207425_-|acyl-CoA-dehydrogenase
MPEFSLDLTEEQRDMRDWVHGFASEVVRPAAAEWDAREETPWPVIQEATKIGLYGFEFLANCWADPTGLSLPIASEELFWGDAGIGLSIFGTSLAVAAIYGSGTPDQLIEWVPQCFGSPDEPAVAAFCTTEPEAGSDVGSMRSRAVYQEATDEWVLNGQKAYATNGGIAGVHVVTASVDPTLGSRGQAAFVIPPGTRGLASTRKLKKLGLRASHTADVFLDDVRVPGSCLLGGREALEERLARARSGQRASGQAAMRTFELSRPTVGAQAIGVARAAYEYALEYAGNRVQFGRPIVENQAVAFALADMKMEIDAARLLVWRASWMGRNNRPFTAGEGSMSKLKAGEVAVSVTGQAVQILGGAGFLREHPVERWYRDAKIYTIFEGTSEIQRLVIARAIAGRQIR
>NZ_CP022961.1|WP_095563209.1|204608_206177_-|AMP-binding-protein
MDLPFTVATLTRRGLLNPGSPVRIAAQLTALHRWGFSLGGELRQAAARDPHRTALIDDRHGAITYGSLLARTERLARALRGTFGVAPGQRVGILCRNHGGLIETAIAASLLGADPVLINTGLSAAQLSIVTEQQDLRVLVYDAEFADRTAGLPPGLHRFDQRRHEELIATAPPDPLSPPASNGRTIVLTSGTTGTPKGARRRTPSGFGPLVSIVDRIPVHCHDRVMIAAPLFHTWGYAALQVSFALRATVVLHHRFDPAATLRALDEHRCTALFAVPVMLQRLLEVPPPATRPPLKVVAVSGSALPGGLATRFMDRYGDVIYNLYGSTEVSWASIATPADLRLASNTAGRPPHGTRLAILDERGDPVPPGHTGRIFVANEMLFEGYTSGNGRESHDGLMETGDLGHLDADGLLFVDGRQDDMIVSGGENVFPSEVEDLLAGLPQVREVAVVGVPDQEYGQRLAAYLVLEPGETLDVDAVREYVRHYRARFSVPRDVFFVPYLPRNATGKIVARELRDLRDLR
>NZ_CP022961.1|WP_095567465.1|202634_204539_+|alkaline-phosphatase
MPSGVSRRSLLGGTGAAAAVIVGLGGAVTQPAVAAAAAGPDPARLKAADPHAFTGRRHGAPVTGVANPRIRILPLDRAKFRAGAHFDLRVEAAGVDPATARIEIAVTGPHGPVPLLKGTPERTSSVAGSLEVTYRGLAYPAAGWHKVTVKVTNGAEKLHAAVTHEVVVAANAGGGRRAKNVIFFLGDGMGAAAITAARLLSKGITEGKYRGLLEMDRMDYRGIVGTSGADSIATDSANSMSAYMTGHKSSVNAMGVYESNATDVNAHPRVETMAELLKRARGMRVGIVTTAEVQDATPAAVFAHTRRRSEYMDIMDQALSAGQRPDVLLGGGLASLLPKSQSGSRRPDERNLVDEFKALGYAYAQDRKQLRAAMSRRPDHLLGLFHTGNMNVYLDRQHTKKPEVLGDWTDQPTLMEMTEAALNVLKDSRDGFFLMVEGASIDKSEHPLDGPRAVYDAIEFDQAIGVAKRWAAHRDDTLIVVTADHNHSMSIIGTHSRAKAAGRAGNGVYADAGFPTYVDHDGDGFPDNPDPDVQLFFGWSNHPDHTDDFQLDAKPTQPALIDPATGKAVANPGNDPGAELQTGNLPFDQTNCVHTVEDVSVVASGPGAHRFNGFLDNTEVFHAIIDALAVNVKK
>NZ_CP022961.1|WP_095563208.1|201870_202461_+|GNAT-family-N-acetyltransferase
MRIREATAADWAQIWPFFRRIVSARETYTYDPDLSQERARELWMPAPPARTVVAVDEAGRVVGSAKMNPNQAGPGAHMGSASFMVDPAHAGRGIGRALGEYVIERCRLDGYRAIQFNAVVETNTRAVRLWRSLGFEVLATVPEAFHHPVHGYVGLHIMHRRLAPPGPIATPPGPATAPTGPGTAPTAPVAGEPPGR
>NZ_CP022961.1|WP_095563207.1|200528_201632_+|arabinogalactan-endo-1,4-beta-galactosidase
MKPYLRALAATLALVVPLALPAPAQAANTLTMLGADVSSLQRSLDLGARYYAASGAQADPYDILKSKGANYLRLRIWNNPASGYNNKAKVLQQARTVKAKGFKLLIDFHYSDTWADPGKQYPPAAWASHSISQLQSDVYNYTYDICTSLRAQGTTPDAVQIGNEINVGMLWPNGKVVNSNFAPLAGLLKQGYNATKACNGGTQVWIHTADADSDANARWFYDGIRSQGVNWDVTALSYYCMWHGTLANLYNVIADVKSRYGKPVVIAETAYQFTTADADGEPNAIPGTQLCDNIPASWSGQAQEFSWVQNTARNAGAVGVFYWEPTWYAIRGNGWDPANINGTGDGWDNMAIFDWTGHVNPNLYWTP
>NZ_CP022961.1|WP_095563206.1|199351_200404_+|LacI-family-transcriptional-regulator
MIPPVPTSPGTGRKRPTIRDVAREAGVSYATVSRVLNGREWVSPEAVRSVRDAIARTGYTTNPHARSLATGRSGSIAFLLTEPQHLLFEDPNFSVLLRGVAQALSDRELTLILMIASSPTERNRTVAYLSGGHVDGVLLVSPHSGDPLLSQLVQAEVPIVACGRVLGYEQLISSVAADDRAGGRSAVEHLIAAGCRRIATISGPQDTSGGVDRLQGYRDALAAHGIPVEPARITHGDWSRESGAAAMRSLLDQAPDLDAVFAASDAMAAGALPVLREAGRDVPGDVRVVGFDDSGLAATLDPPLSTVRHPLDRISEEMVRLLTDLIAGRTPLSITVPTTLVVRSSSPAPG
>NZ_CP022961.1|WP_095563215.1|211135_212428_+|acetyl-CoA-C-acetyltransferase
MQDVRRAAVLGGNRIPFARSNGRYARASNQDMLTAALDGLVARFGLAGQRVGEVVAGAVLKHSRDFNLTREVVLGSRLDPHTPAYDIQRACGTGLEAAILVANKIALGQVDAGIAGGVDTTSDAPLAVNEDFRRTLLRINSARSLGARLRAATALRPHHPFKPEVPRNAEPRTGLSMGDHAAVTARRWNVDRQAQDELALASHQRLAAAYQRGFFDDLLTPYLGLERDQNLRADTSLEKLGALRPVFGTRGPDAGTATMTPGNSSPLTDGASTVLLGSAEWAAAHNLPVLAWFRDAETAAVDFVHGDEGLLMAPAYAVPRLLARNGLTLQDFDFYEIHEAFASQVLATLAAWESPEFCKERLGLDAPLGPIDRSRLNVNGSSLAAGHPFAATGGRIVATLAKLLAEKGSGRGLISICAAGGQGVVAILER
>NZ_CP022961.1|WP_095563216.1|212447_213347_+|alpha/beta-hydrolase
MTGTDSHTLDVPGAVLHYDLHPAQPAAAAQPGTPPYGAPALLMIGSPMTAAGFTSLAARFPDRTVVTYDPRGVGRSTRTDPSAETTPERHADDLHRIISALGAGPVDIFASSGGAVNALVLVARHPEQVRVLVAHEPPSVPVLPDSEPAHAAVLDVQRTYQRDGFGAAMVKFMALSSWQGEVPADFADRPTPDPTSFGLPADDGSRDDALFAGNLVSCTQQRPDFDALRAASTRVVLAAGVESAGQLAARAAAAIAERLGTGAVEFPSNHGGFLGGEFGMHGDPDGFAATLREVLAGRS
>NZ_CP022961.1|WP_095563217.1|213429_215784_-|penicillin-binding-protein
MIRPAAGVPRPAAGASRPPAAPRDHRWRRRLLVGLAVLAVLAGFGLIGGIYYVDSVPTPVDLRLPESTTVYYSDGRTPMATLGSENRTIVPYDQMNDAPKQAIVAAEDRTFWRNPGIDFSGVLRAAWSNLTGGQRQGASTITQQYARVAADLKGVTYSRKLREAVIAWKLDDAYSKQEILGFYLNTVPFGRGAYGIEAAAQAYFGKTVRRDAPADRQLTVAEAMVLCAMVKQPEANPEDPDGEPGYDPRRNPLARQNSINRWNYIRDGMVKLNYLTPDQAAELAYPDTVKPFDPDAGQSGLDRPTGLVVKHVLSELRQVEPFQGKPADYLPNGGFKIVTTIDKRVQDVAEASADIRRDSAPAQVRGQPKNWQAALVAVQPGTGRVLGYYGGSSGTGADYAGWYYDENGAARGFGQHPPGSSFKVYDLAAAVQDGISVKQRFNSPDTKEFPGSGRTKGSAAGPIRNAEHAACQPNCALWEATVASLNVTYFELTEQLGKAKVIDMATRAGVDSMWRDLPGDPQPKRVPLRDQPAAETAKQFSTEVGIGQYGITVQDHANGMATFAAGGKRADAHFVRSVEKDDEHIFDEQLTQTDLGLDDEAVNQLNWTLRRVRAAKLGNGWDSAGKTGTWQAGQSTTQNVHTWMVGYTGALAAAVWLGTTDGKPLKTRDGSYEVYGATGPAPIWRQFMEQATAALKLDPDRYRFKEPKFPNDAPEPSPSPPSPTPSPVEPSATTPGPSPSEPEPTCDEQPCASTSPTPLPTPTRSRIISITPSPPRSVRPSRGQ
>NZ_CP022961.1|WP_095563218.1|216052_216622_+|helix-turn-helix-transcriptional-regulator
MSLGDGSDGNHPAGTPQESTIRLRALAHPVRLRILSLLTGAPLTAAEVARELDLTHANASYHLRQLLAAGAIVVTAQERIRGGAAKRYRYDPDRDRDRERDERAKHDHQGQRVVYEAVSTELRRRAEHRRAGGTGHLADAELWVDPEVWAEVREQVADAMVRLHRAARAPRSPGTTHVNATVALFEMED
>NZ_CP022961.1|WP_095563219.1|216621_217962_+|MFS-transporter
MFAPLRYAAFRYLALGRMINVLGNAVAPIALAFAVLDLTGSVRDLGLVVGARSLMNVIFVLFGGVLADRLPRRVVLVGSNALGALTQGIVAALVLTGTASIPLLLALSAANGLVSALAQPASAALTPQTVPGELIQPANAINRLGINTAMISGAAVGGILVAAVGPGWGLAADAVTFGLSALAFVRIRVPSVVTDPGGARRSVLADLRVGWSEFSGRTWLWAVVLGFMVLNASLAGGVNVLGPAVADETVGRSAWGLVLAAEAAGMIVGGLVALRVRVRRLLRFGVACMFAEALLLLGLALAPRVFVLVPAAMIVGMAVEQFAVAWETSMAQHIPPDRLARVYSYDMLGSFVAIPLGQVVVGPAAAVFGNRDTLLGAAVLVVLSVLGMLASRDVRRLPAGAPATGKPTGDGPAGDGRVGGEPVGGLPATAAGPERAGAVPVAADPA
>NZ_CP022961.1|WP_095563220.1|218036_219461_+|adenylosuccinate-lyase
MTAIPNVLAARYASPELAALWSPEEKIRMERRLWVAVLRAQRDLGVPVPDGVVEAYERVLDQVDLASIAERERVTRHDVKARIEEFSALAGYEHVHKGMTSRDLTENVEQLQVRASLELIRDRVVAALARLAWLAHEHSALVMAGRSHNVAAQATTLGKRFGSAAEELLIAYERLADLLGRYPLRGIKGPVGTAADQLDLFDGDADKVAELERRVAGHLGFSRVLNSVGQVYPRSLDLDVLSALAQTAAAPSSLATTIRLMVGQELVTEGFRPGQVGSSAMPHKMNTRSSERVNGLAVVIRGYLSMVGELAGDQWNEGDVSCSVVRRVALPDAFFAADGLFQTFLTVLDEFGAYPAVIARELDRYLPFLATTRILVGAVRRGVGREVAHEVIKEHAVAVALAMREKGTVENDLFDRLAADGRLGLSRAEIDELVADQSAFIGVARDQVDAVTRRISEVVTAHPEAAAYSPPPIL
>NZ_CP022961.1|WP_095563221.1|219542_220058_-|YbjQ-family-protein
MRPREHASQIPPTRSASIETVLVVTMDHLPGYEIREVLGQVVSSQARTRNVYREGVKSLRGGAYDPAAPENLTRWRTDAVARLGEEARRLGANAVLGMRFEHREVGEMWMEVCAYGTAVVAYRSPAAPAPDQPLVAAETAHPAEPIDSGAIAEAPSAPNLRTAGETPTRPD
>NZ_CP022961.1|WP_095563222.1|220349_220610_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MPRVVVDVMLKPEILDPQGQAVANALPSLGVNDVASVRIGRRIELEFTGQPDLDQVRSLADKLLANPVIEDFTVRVAEPGEAAVTP
>NZ_CP022961.1|WP_095563223.1|220606_221290_+|phosphoribosylformylglycinamidine-synthase-subunit-PurQ
MSPRIGVVTFPGSLDDGDAARAVRIAGAEAVRLWHADPELHGVDAVVLPGGFSYGDYLRCGAIARFAPVMRTLVDAARDGLPVLGVCNGFQILCEAHLLPGALTRNGHLHFRNRDQVLRVEANGTAWTNAFHPQQEILIPVKNGEGRYVADERTLDELAAQGRIVARYLGENPNGSQRDIAAISNEAGNVVGIMPHPEHAVEELTGPSLDGLGFFTSILKHLAGAPA
>NZ_CP022961.1|WP_095563224.1|224222_224981_+|hypothetical-protein
MTVPVYGQPGTGVRFDWGLSGAAELGRVCSVLVIVDVLSFTTSAEVAVSRGMRVHPFPWGAQAADYAARVGAVAAVGRGAADHGHPWSLSPAALRSAPVVPDLVLPSPNGSAICSAAASSGVPVVTACLRNAAAVGRWLLAEGYGSADRPVGVVAAGERWTDGTLRPCVEDQLGAAAVLDGLSTAPGTLSVEAAVALAVLGAIPNIPAAVRGCVSGRELLERGFGEDVEIAARVNISGTVTVLRNGVLTRAD

Crispr_ID: NZ_CP022961_3

• CRISPR_ID: NZ_CP022961_3
• CRISPR_location: 399385-401059
• CRISPR_type: Orphan
• Repeat_type: I-E
• Spacer_info: 27 spacers

Consensus repeat of NZ_CP022961_3

Consensus_repeat	Method
GTGCTCCCCGCGCATGCGGGGGTGATCC	PILER-CR
GTGCTCCCCGCGCATGCGGGGGTGATCC	CRISPRCasFinder
GTGCTCCCCGCGCATGCGGGGGTGATCC	CRT

spacers of NZ_CP022961_3

>3.1|399413|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTTCCAGGTCATACCCGCGGAGGTGACGCCCTT
>3.2|399474|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTGCAACCTCGGTCACGTCAATCTCGGCGCCTT
>3.3|399535|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTGTAGGAAACTGAAGGGCCGAAGTCAACAGGA
>3.4|399596|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTGCCGGAGAAACATCTCCGGCCGCAACCGTAA
>3.5|399657|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CCCGGAGGCGACCCGCGCGGATATGTAACAGCC
>3.6|399718|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GTCCGGACATCCCGGCCTTCCAGCCCACTCTTG
>3.7|399779|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GTCGACCAAGACCGTCTTGCCATCCTTGGTCAC
>3.8|399840|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
TCAAACGACATCCGCGACTCCCTTCTCTTGGAG
>3.9|399901|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTGGCGAAGGTCAGAAACATAACCGGAGAGCAT
>3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTCCTCCGCCCGGTAGGCGGCGGCCCGCCGGTC
>3.11|400023|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CGGGTGGCTCAAGTCTCCGGAGCCGGCCACACC
>3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GCGGGCCATCACCCCGGTCGCCGGCTTGCGGCG
>3.13|400145|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
TCCCGGGACGTCTGACCACACGACGAAGCCCCG
>3.14|400206|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
ATGCGGTCTGTCCCCTCAGCCGCCGGCTGACGT
>3.15|400267|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GTGCCAAGACGGCAAAACCACAGGTCAGGGGCC
>3.16|400328|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
TGTCCTGGTAGCTCTTGCCGGACGCGGCGGGTT
>3.17|400389|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTACGGGCCGCACCCGTCGCTAGCCTGACTAGA
>3.18|400450|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
>3.19|400511|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
>3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CGCGCCGCCGCCGGGGATCGCCCCGAGTGCTGT
>3.21|400633|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CCGGGGGGCCACCGCGCGCCTGCGGCGACTGTC
>3.22|400694|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GGAACCGATCAGAGTGATCAGGTTGTCGAACAG
>3.23|400755|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GTAGCGAGGTTGAGCGACCACCGCACCCGCTCC
>3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GGGCGGCAGGCCCTTCAGCCACAGGCAGGTCGT
>3.25|400877|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GCCGTAGAGCGCGCTCGATCGGTTGCGCGGGTT
>3.26|400938|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
TTTCCGAGCGACCCACCTCCGCCACAACCCGAA
>3.27|400999|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTGTCACAACATCAATATCAACAGGGCTTTGAC

CRISPR arrays and Neighbor proteins around NZ_CP022961_3

CRISPR arrays

The CRISPR arrays of NZ_CP022961_3

>merge|NZ_CP022961|3|399385-401059|PILER-CR,CRISPRCasFinder,CRT
GTGCTCCCCGCGCATGCGGGGGTGATCCCTTCCAGGTCATACCCGCGGAGGTGACGCCCTTGTGCTCCCCGCGCATGCGGGGGTGATCCCTGCAACCTCGGTCACGTCAATCTCGGCGCCTTGTGCTCCCCGCGCATGCGGGGGTGATCCCTGTAGGAAACTGAAGGGCCGAAGTCAACAGGAGTGCTCCCCGCGCATGCGGGGGTGATCCCTGCCGGAGAAACATCTCCGGCCGCAACCGTAAGTGCTCCCCGCGCATGCGGGGGTGATCCCCCGGAGGCGACCCGCGCGGATATGTAACAGCCGTGCTCCCCGCGCATGCGGGGGTGATCCGTCCGGACATCCCGGCCTTCCAGCCCACTCTTGGTGCTCCCCGCGCATGCGGGGGTGATCCGTCGACCAAGACCGTCTTGCCATCCTTGGTCACGTGCTCCCCGCGCATGCGGGGGTGATCCTCAAACGACATCCGCGACTCCCTTCTCTTGGAGGTGCTCCCCGCGCATGCGGGGGTGATCCCTGGCGAAGGTCAGAAACATAACCGGAGAGCATGTGCTCCCCGCGCATGCGGGGGTGATCCCTCCTCCGCCCGGTAGGCGGCGGCCCGCCGGTCGTGCTCCCCGCGCATGCGGGGGTGATCCCGGGTGGCTCAAGTCTCCGGAGCCGGCCACACCGTGCTCCCCGCGCATGCGGGGGTGATCCGCGGGCCATCACCCCGGTCGCCGGCTTGCGGCGGTGCTCCCCGCGCATGCGGGGGTGATCCTCCCGGGACGTCTGACCACACGACGAAGCCCCGGTGCTCCCCGCGCATGCGGGGGTGATCCATGCGGTCTGTCCCCTCAGCCGCCGGCTGACGTGTGCTCCCCGCGCATGCGGGGGTGATCCGTGCCAAGACGGCAAAACCACAGGTCAGGGGCCGTGCTCCCCGCGCATGCGGGGGTGATCCTGTCCTGGTAGCTCTTGCCGGACGCGGCGGGTTGTGCTCCCCGCGCATGCGGGGGTGATCCCTACGGGCCGCACCCGTCGCTAGCCTGACTAGAGTGCTCCCCGCGCATGCGGGGGTGATCCCGAGACAGCCGGAAACGCGCCGCGGGTCCCCCTGTGCTCCCCGCGCATGCGGGGGTGATCCCGAGACAGCCGGAAACGCGCCGCGGGTCCCCCTGTGCTCCCCGCGCATGCGGGGGTGATCCCGCGCCGCCGCCGGGGATCGCCCCGAGTGCTGTGTGCTCCCCGCGCATGCGGGGGTGATCCCCGGGGGGCCACCGCGCGCCTGCGGCGACTGTCGTGCTCCCCGCGCATGCGGGGGTGATCCGGAACCGATCAGAGTGATCAGGTTGTCGAACAGGTGCTCCCCGCGCATGCGGGGGTGATCCGTAGCGAGGTTGAGCGACCACCGCACCCGCTCCGTGCTCCCCGCGCATGCGGGGGTGATCCGGGCGGCAGGCCCTTCAGCCACAGGCAGGTCGTGTGCTCCCCGCGCATGCGGGGGTGATCCGCCGTAGAGCGCGCTCGATCGGTTGCGCGGGTTGTGCTCCCCGCGCATGCGGGGGTGATCCTTTCCGAGCGACCCACCTCCGCCACAACCCGAAGTGCTCCCCGCGCATGCGGGGGTGATCCCTGTCACAACATCAATATCAACAGGGCTTTGACGTGCTCCCCGCGCATGCGGGGGTGATCC

>NZ_CP022961|3|1|399385-401059|PILER-CR
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTTCCAGGTCATACCCGCGGAGGTGACGCCCTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGCAACCTCGGTCACGTCAATCTCGGCGCCTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGTAGGAAACTGAAGGGCCGAAGTCAACAGGA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGCCGGAGAAACATCTCCGGCCGCAACCGTAA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CCCGGAGGCGACCCGCGCGGATATGTAACAGCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTCCGGACATCCCGGCCTTCCAGCCCACTCTTG
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTCGACCAAGACCGTCTTGCCATCCTTGGTCAC
GTGCTCCCCGCGCATGCGGGGGTGATCC	TCAAACGACATCCGCGACTCCCTTCTCTTGGAG
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGGCGAAGGTCAGAAACATAACCGGAGAGCAT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTCCTCCGCCCGGTAGGCGGCGGCCCGCCGGTC
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGGGTGGCTCAAGTCTCCGGAGCCGGCCACACC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GCGGGCCATCACCCCGGTCGCCGGCTTGCGGCG
GTGCTCCCCGCGCATGCGGGGGTGATCC	TCCCGGGACGTCTGACCACACGACGAAGCCCCG
GTGCTCCCCGCGCATGCGGGGGTGATCC	ATGCGGTCTGTCCCCTCAGCCGCCGGCTGACGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTGCCAAGACGGCAAAACCACAGGTCAGGGGCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	TGTCCTGGTAGCTCTTGCCGGACGCGGCGGGTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTACGGGCCGCACCCGTCGCTAGCCTGACTAGA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGCGCCGCCGCCGGGGATCGCCCCGAGTGCTGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CCGGGGGGCCACCGCGCGCCTGCGGCGACTGTC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GGAACCGATCAGAGTGATCAGGTTGTCGAACAG
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTAGCGAGGTTGAGCGACCACCGCACCCGCTCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GGGCGGCAGGCCCTTCAGCCACAGGCAGGTCGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	GCCGTAGAGCGCGCTCGATCGGTTGCGCGGGTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	TTTCCGAGCGACCCACCTCCGCCACAACCCGAA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGTCACAACATCAATATCAACAGGGCTTTGAC
GTGCTCCCCGCGCATGCGGGGGTGATCC

>NZ_CP022961|3|3|399385-401059|CRISPRCasFinder
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTTCCAGGTCATACCCGCGGAGGTGACGCCCTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGCAACCTCGGTCACGTCAATCTCGGCGCCTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGTAGGAAACTGAAGGGCCGAAGTCAACAGGA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGCCGGAGAAACATCTCCGGCCGCAACCGTAA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CCCGGAGGCGACCCGCGCGGATATGTAACAGCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTCCGGACATCCCGGCCTTCCAGCCCACTCTTG
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTCGACCAAGACCGTCTTGCCATCCTTGGTCAC
GTGCTCCCCGCGCATGCGGGGGTGATCC	TCAAACGACATCCGCGACTCCCTTCTCTTGGAG
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGGCGAAGGTCAGAAACATAACCGGAGAGCAT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTCCTCCGCCCGGTAGGCGGCGGCCCGCCGGTC
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGGGTGGCTCAAGTCTCCGGAGCCGGCCACACC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GCGGGCCATCACCCCGGTCGCCGGCTTGCGGCG
GTGCTCCCCGCGCATGCGGGGGTGATCC	TCCCGGGACGTCTGACCACACGACGAAGCCCCG
GTGCTCCCCGCGCATGCGGGGGTGATCC	ATGCGGTCTGTCCCCTCAGCCGCCGGCTGACGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTGCCAAGACGGCAAAACCACAGGTCAGGGGCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	TGTCCTGGTAGCTCTTGCCGGACGCGGCGGGTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTACGGGCCGCACCCGTCGCTAGCCTGACTAGA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGCGCCGCCGCCGGGGATCGCCCCGAGTGCTGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CCGGGGGGCCACCGCGCGCCTGCGGCGACTGTC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GGAACCGATCAGAGTGATCAGGTTGTCGAACAG
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTAGCGAGGTTGAGCGACCACCGCACCCGCTCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GGGCGGCAGGCCCTTCAGCCACAGGCAGGTCGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	GCCGTAGAGCGCGCTCGATCGGTTGCGCGGGTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	TTTCCGAGCGACCCACCTCCGCCACAACCCGAA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGTCACAACATCAATATCAACAGGGCTTTGAC
GTGCTCCCCGCGCATGCGGGGGTGATCC

>NZ_CP022961|3|1|399385-401059|CRT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTTCCAGGTCATACCCGCGGAGGTGACGCCCTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGCAACCTCGGTCACGTCAATCTCGGCGCCTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGTAGGAAACTGAAGGGCCGAAGTCAACAGGA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGCCGGAGAAACATCTCCGGCCGCAACCGTAA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CCCGGAGGCGACCCGCGCGGATATGTAACAGCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTCCGGACATCCCGGCCTTCCAGCCCACTCTTG
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTCGACCAAGACCGTCTTGCCATCCTTGGTCAC
GTGCTCCCCGCGCATGCGGGGGTGATCC	TCAAACGACATCCGCGACTCCCTTCTCTTGGAG
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGGCGAAGGTCAGAAACATAACCGGAGAGCAT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTCCTCCGCCCGGTAGGCGGCGGCCCGCCGGTC
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGGGTGGCTCAAGTCTCCGGAGCCGGCCACACC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GCGGGCCATCACCCCGGTCGCCGGCTTGCGGCG
GTGCTCCCCGCGCATGCGGGGGTGATCC	TCCCGGGACGTCTGACCACACGACGAAGCCCCG
GTGCTCCCCGCGCATGCGGGGGTGATCC	ATGCGGTCTGTCCCCTCAGCCGCCGGCTGACGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTGCCAAGACGGCAAAACCACAGGTCAGGGGCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	TGTCCTGGTAGCTCTTGCCGGACGCGGCGGGTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTACGGGCCGCACCCGTCGCTAGCCTGACTAGA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGAGACAGCCGGAAACGCGCCGCGGGTCCCCCT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CGCGCCGCCGCCGGGGATCGCCCCGAGTGCTGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	CCGGGGGGCCACCGCGCGCCTGCGGCGACTGTC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GGAACCGATCAGAGTGATCAGGTTGTCGAACAG
GTGCTCCCCGCGCATGCGGGGGTGATCC	GTAGCGAGGTTGAGCGACCACCGCACCCGCTCC
GTGCTCCCCGCGCATGCGGGGGTGATCC	GGGCGGCAGGCCCTTCAGCCACAGGCAGGTCGT
GTGCTCCCCGCGCATGCGGGGGTGATCC	GCCGTAGAGCGCGCTCGATCGGTTGCGCGGGTT
GTGCTCCCCGCGCATGCGGGGGTGATCC	TTTCCGAGCGACCCACCTCCGCCACAACCCGAA
GTGCTCCCCGCGCATGCGGGGGTGATCC	CTGTCACAACATCAATATCAACAGGGCTTTGAC
GTGCTCCCCGCGCATGCGGGGGTGATCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095563338.1|398572_398725_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP022961.1|WP_095563336.1|397237_398281_+|c-type-cytochrome-biogenesis-protein-CcsB	unknown	unknown	gnl|CDD|274447
NZ_CP022961.1|WP_095567490.1|402732_403275_+|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl|CDD|225039
NZ_CP022961.1|WP_095567491.1|408837_409452_-|hypothetical-protein	unknown	unknown	gnl|CDD|377662
NZ_CP022961.1|WP_095563346.1|407609_408701_+|PLP-dependent-cysteine-synthase-family-protein	unknown	unknown	gnl|CDD|223110
NZ_CP022961.1|WP_095563331.1|392214_393573_+|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl|CDD|234607
NZ_CP022961.1|WP_095563342.1|404817_405720_+|4-hydroxybenzoate-octaprenyltransferase	unknown	unknown	gnl|CDD|183814
NZ_CP022961.1|WP_157756565.1|411590_413210_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP022961.1|WP_095563340.1|401197_402004_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|224001
NZ_CP022961.1|WP_095563334.1|394803_395628_+|cytochrome-C-biogenesis-protein	unknown	unknown	gnl|CDD|280792
NZ_CP022961.1|WP_095563332.1|393569_394217_+|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|366010
NZ_CP022961.1|WP_095563337.1|398246_398435_-|EamA-family-transporter	unknown	unknown	gnl|CDD|307170
NZ_CP022961.1|WP_095563343.1|405764_406412_+|UbiX-family-flavin-prenyltransferase	unknown	unknown	gnl|CDD|223241
NZ_CP022961.1|WP_095563330.1|391749_392085_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP022961.1|WP_095563333.1|394216_394804_+|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NZ_CP022961.1|WP_095563345.1|407096_407555_+|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP022961.1|WP_095563339.1|399017_399203_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563341.1|403357_404821_+|menaquinone-biosynthesis-decarboxylase	unknown	unknown	gnl|CDD|163413
NZ_CP022961.1|WP_095563335.1|395627_397238_+|cytochrome-c-biogenesis-protein-ResB	unknown	unknown	gnl|CDD|377471
NZ_CP022961.1|WP_095563344.1|406570_406843_-|BldC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133390

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095563338.1|398572_398725_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	6.16236e-17
NZ_CP022961.1|WP_095563336.1|397237_398281_+|c-type-cytochrome-biogenesis-protein-CcsB	gnl|CDD|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	9.55403e-80
NZ_CP022961.1|WP_095567490.1|402732_403275_+|carboxymuconolactone-decarboxylase-family-protein	gnl|CDD|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	4.27365e-14
NZ_CP022961.1|WP_095567491.1|408837_409452_-|hypothetical-protein	gnl|CDD|377662	pfam06475, Glycolipid_bind, Putative glycolipid-binding. This family has a novel fold known as a spiral beta-roll, consisting of a 15-stranded beta sheet wrapped around a single alpha helix. It forms dimers. It has some structural similarity to the E. coli lipoprotein localization factors LolA and LolB. Its structure suggests that it may have a role in glycolipid binding. Its genomic context supports a role in glycolipid metabolism.	2.55731e-40
NZ_CP022961.1|WP_095563346.1|407609_408701_+|PLP-dependent-cysteine-synthase-family-protein	gnl|CDD|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	3.7275e-97
NZ_CP022961.1|WP_095563331.1|392214_393573_+|glutamate-1-semialdehyde-2,1-aminomutase	gnl|CDD|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_CP022961.1|WP_095563342.1|404817_405720_+|4-hydroxybenzoate-octaprenyltransferase	gnl|CDD|183814	PRK12888, ubiA, 4-hydroxybenzoate octaprenyltransferase.	2.3472e-161
NZ_CP022961.1|WP_157756565.1|411590_413210_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	6.40885e-16
NZ_CP022961.1|WP_095563340.1|401197_402004_-|alpha/beta-fold-hydrolase	gnl|CDD|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	7.50643e-22
NZ_CP022961.1|WP_095563334.1|394803_395628_+|cytochrome-C-biogenesis-protein	gnl|CDD|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	1.31112e-32
NZ_CP022961.1|WP_095563332.1|393569_394217_+|histidine-phosphatase-family-protein	gnl|CDD|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.48467e-38
NZ_CP022961.1|WP_095563337.1|398246_398435_-|EamA-family-transporter	gnl|CDD|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	1.66895e-05
NZ_CP022961.1|WP_095563343.1|405764_406412_+|UbiX-family-flavin-prenyltransferase	gnl|CDD|223241	COG0163, UbiX family flavin prenyltransferase [Coenzyme transport and metabolism].	2.70778e-68
NZ_CP022961.1|WP_095563330.1|391749_392085_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.59567e-20
NZ_CP022961.1|WP_095563333.1|394216_394804_+|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	2.40161e-36
NZ_CP022961.1|WP_095563345.1|407096_407555_+|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.41211e-40
NZ_CP022961.1|WP_095563341.1|403357_404821_+|menaquinone-biosynthesis-decarboxylase	gnl|CDD|163413	TIGR03701, mena_SCO4490, menaquinone biosynthesis decarboxylase, SCO4490 family. Members of this protein family are putative decarboxylases involved in a late stage of the alternative pathway for menaquinone, via futalosine, as in Streptomyces coelicolor and Helicobacter pylori. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NZ_CP022961.1|WP_095563335.1|395627_397238_+|cytochrome-c-biogenesis-protein-ResB	gnl|CDD|377471	pfam05140, ResB, ResB-like family. This family includes both ResB and cytochrome c biogenesis proteins. Mutations in ResB indicate that they are essential for growth. ResB is predicted to be a transmembrane protein.	7.10446e-157
NZ_CP022961.1|WP_095563344.1|406570_406843_-|BldC-family-transcriptional-regulator	gnl|CDD|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	3.06622e-16

Protein sequences

>NZ_CP022961.1|WP_095563339.1|399017_399203_+|hypothetical-protein
MMERDERPVRVPVSLDAWRWPVRIGDLVCGECDVTLRIHQFTAMSELAAAVERHALVCVMS
>NZ_CP022961.1|WP_095563338.1|398572_398725_-|DUF397-domain-containing-protein
MCGTNQGNCVEVADNLPGRVLVRDSKDRSGPVLTFAPAVWSAFVAGTPRR
>NZ_CP022961.1|WP_095563337.1|398246_398435_-|EamA-family-transporter
MGTSTWLPIAYLGVVGTAYAFGIQLYAVRRGSPTRVAIFMSTEPVFARPIAATSPRRTSAGR
>NZ_CP022961.1|WP_095563336.1|397237_398281_+|c-type-cytochrome-biogenesis-protein-CcsB
MAELSDQLLVVAIFAYLIAMICHAAEYAFGNRAAVGRGSIRPARELVAAGAGGSVPAPEPDGMTTGPDGMTTGPDGMTTGPDGTATEPVVDRGPGRAALMGRLAVSATALAAVAHLATIVTRGIAADRLPWGNMYEYVLVATFVAVVGWFVVLRGAPGVRHLGLFVAVAEVLLLAMAGLVVYVPIGPLVPALNSYWFVIHITAVSLASGLFLLGAVPAVMFLIRDGYEQGKRRFPYSLGRRVPAAAPLERMTFRLHTFAFPIWTFGVMAGAVWAEAAWGRYWGWDPKETWAFISWVVYAGYLHARATPSVKRSLATWIAVLGFVTMLINLFGVNLFISGLHSYAGVK
>NZ_CP022961.1|WP_095563335.1|395627_397238_+|cytochrome-c-biogenesis-protein-ResB
MATATGVTGPPAAPPTLPPGRPNRALALLRNSWRQLTSMRTALVLLFLLAVAAIPGSLLPQRGVNIEQVNDWQAAHPKLFPVLNSVGAFEVFASPWFSAVYVLLFVSLVGCIVPRARDHLRALRGAPPAGPRRLDRLPQHRVRTDPAATDPAAIAAVLRRRRWRVAVRGDTVAAEKGYLKETGNLVFHLSLIAVLLGVALGNWYGWHGNRMLVAGPDRTFCNGLQQYDESGLGPRLDASDLPSFCLELTDFQATYQQSGQPRSFRASVRVQEPGRASRLTDFSVNDPLRLHHANVYLLGHGYAPVIRYTDRYGRTQTTVAPFLTEDGLLTGQGVATFPDVDLDPETGTRDPDQQVAFDGLYLPTAPDSAPYIRSEFPAERNPLLNVVAYRGNLGLDAGIPGSVYRLDQRQISAGKLKQVGTKVMRPGDTWTLDDGSRMEFLGTRPYVTLAVRYDPGEKIVLGGAVALLVGLMLSLTGRRRRVWFRVVGAPTEGSTTDGSSLVEAGGLPRTDYSGFADEFDQLVTAVTGDRKREGTD
>NZ_CP022961.1|WP_095563334.1|394803_395628_+|cytochrome-C-biogenesis-protein
MGAAFADLARSGPLLLAVGAAALAGLVSFLSPCVLPLVPGYLSYVTGLAGTDLERGATDLDRGGAGKVSRPVMVAPSRAVRSVKGRVLAGTLLFIAGFTAVYLLTAILLAGIGQAMLMHRRALEVVVGAVIMVLGVAFLGFIPGLQREFRLHRLPAAGLLGAPVFGAVFALSWAPCTGPTLGAVLGLATVGGQTDRAAVLAVAYCLGLGLPFMIFGLGFSRLLGLFRAIRRNSRWVTRLGGALLIIVGLALVTGGWQDFIIWLQTTVGPGEVGI
>NZ_CP022961.1|WP_095563333.1|394216_394804_+|TlpA-family-protein-disulfide-reductase
MAGPRRVSGVLAGAVAVLALGTAGCSGDGSGFDWRRDCETTPEGVVQCAPGNRPPPTPISGELLDGGSYDVTQDRGQVVVVNFWGSWCAPCRAEADDLESTYQATRDAGVRFLGINARDGQDAARAFERGRLTYPSLYDPGGKLALGFQVPPNSIPATVILDRAGRIAVVIRRAVRADDLRPVVDRVAAEEPARD
>NZ_CP022961.1|WP_095563332.1|393569_394217_+|histidine-phosphatase-family-protein
MSETVVHLLRHGEVHNPEKILYGRLPGYRLSELGVQMAKAAAQAVAERDIVHVVASPLERAQQTADPIAAQFGLPVGVDERLIESANWFEGKRVSPGDGSFRDPRNWWVLRDPLTPSWGEAYTVIAQRMFGALQAARLAAEGREALCVSHQLPIWTLRRYVERKRLWHDPRRRQCGLASLTSFHFDGAKIVGIGYSEPAAHLVALSPNARTAKGA
>NZ_CP022961.1|WP_095563331.1|392214_393573_+|glutamate-1-semialdehyde-2,1-aminomutase
MTDPYPAGGAPYPSAAPASEALFDRALGIVPGGVNSPVRAFRAVGGTPRFMVRGSGAWLFDADGRRYVDLVASWGPLLLGHAHPEVVAAVQAAAANGTSFGTPTPGEVDLAAEIVARTPVEQVRLVNSGTEATMSAIRLARGFTGRSKIVKFAGCYHGHVDALLAAAGSGVATLGLPDSPGVTGAAAGETIVLPYNDAAAVEAVFAEQGQHIAAIITEAAAGNMGVVAPRDGFNARLAGIAHAYGALLILDEVMTGFRVSRGGWAGHQPVEADLFTYGKVMGGGLPAAAFGGRAGIMSRLAPAGPVYQAGTLSGNPLACAAGFATLRLADDAVYRRLDEVADRLGRLAGDALTAAGVPHRLSTAGNMFSIFFSDVDVRDYETASGQDVAAYRAFFHSMLADGVYLPPSAFEAWFVSDALATDDAALDRIADALPRAATAAAKAHTNESGGQA
>NZ_CP022961.1|WP_095563330.1|391749_392085_-|STAS-domain-containing-protein
MERAELTIRVQRTTDEVTLGLAGEIDMLTAVRLSAVVNEALAEPPPRIVLDLAGVTFCDSQGLGTLVVLSRKASHAQSLLMLTNVGEFLIRVLDITGLRSALMIRNEQSAS
>NZ_CP022961.1|WP_095563340.1|401197_402004_-|alpha/beta-fold-hydrolase
MLLRKILVTVIATTTAAVLATPAAAGATAGTAKTAGATAGTTSTAGATAAANPVIVVAGLSGVASAYEPLAARLRADGYRVFIYQLPGLGFGDIADSATAFKGYVEQVRASTGAARVDLVAHSEGGLVSRYYLRNLGGTGSVGRYVSLGTPQYGTYVANIVAFIGLGSCIGIIACQQMTIGSSFLAALNSGDDAPGDVRYTTIRTAQDELVRPTPNATLSGGATNILVQGYCPLRVVGHLGLVLDGTTYTIVRAALRDAAIRPDCFAL
>NZ_CP022961.1|WP_095567490.1|402732_403275_+|carboxymuconolactone-decarboxylase-family-protein
MPDVFPTHTIDTAPLQSRPLLERVRRGFGYLPAAVGLMAESPHLLDGFLTANRTFEASALDPVQREVVVLTVATRNDCHLCLALHTAALHRLGAPAELIAALRAGTPPPDPRLAALHRFTLAVLDHRGRVPDADLADFFGAGYAARHALDVVLGIGTYTMSTFANRLLGAPIDEPLRPYA
>NZ_CP022961.1|WP_095563341.1|403357_404821_+|menaquinone-biosynthesis-decarboxylase
MAPHGFPYPDLKDFLAALERAGELRRVGVPVDPTLEISEVVTRTVRAGGPALLFERPTRGEMPVAINLYGTEKRTAMALGVDSLDEIGDRIGALVKPELPVGWSGIREGLGKVLQLRSVPPRKVKTAPCQQVVYRGAEVDLNRLPGLQVWPGDGGVFHNFGLTHTKHPETGKRNLGLYRLQQHSPNTLGMHWQIHKDSTAHHAVAERLGQRLPVAVAIGCDPVLNYAATAPLPGDIDEYLFAGFLRGERVEMVDCLSVPLQVPAQAQVVLEGYLEPGERLPEGPFGDHTGFYTPVEPFPVLHVETMTMQREPVYHSIVTSQPPQEDHGLGKATERIFLPLLRLLIPDIVDYDLPAAGVFHNCVIVSIHKRYPKHAQKVMNAIWGAHLLSLSKLIVVVDDDCDVHDYAQVAFRAFGNVDYAHDLLLTQGPVDHLDHASYQQFWGGKAGVDATRKLPTEGYTRGWPEQMRMSPEVTALVDKRWKEYGIS
>NZ_CP022961.1|WP_095563342.1|404817_405720_+|4-hydroxybenzoate-octaprenyltransferase
MTALAERPGRVRSFLKLVAIEHSVFALPFAYLSALTAMRATGGRIRWVDLLLITVAMVGARTFAMAANRIIDRRVDARNPRTAGRELVTGAVSVRTAWTGAVVALVVFLGAAALLNPLCLALAPLAAVPLVVYPYGKRFTDFPHAILGIAQAVGPVGAWLAVTGTFAGSGPAWLLGAAVGLWIGGFDLIYACQDAEVDRRIGVRSVPARYGVRAALHASTVAHIVTFLLFVWFGQLVGFGWPWWLGLLLTAVAFGYQHVVVSPTDLSKVNRAFFTANGFVGIALFVFALLDLVFRLDLRA
>NZ_CP022961.1|WP_095563343.1|405764_406412_+|UbiX-family-flavin-prenyltransferase
MRRPWVVGVSGASGTPYAAAVLRGLLDAGSPVDLVISRAARLTLLDETGRPFRDAHWKDDLAGWLGRDLAGADLAYWPAGDLAAAPSSGSYPVCGMVVVPASTAACAGIAIGLSKDLLQRAAEVNLKERRPLVVVPRETPVTRSHLEHLIALHDAGAVVLPASPGFYGAGADASAGQLVDFVAGKVLDALGVPHTLFRRWTGDLGAARDRADRPE
>NZ_CP022961.1|WP_095563344.1|406570_406843_-|BldC-family-transcriptional-regulator
MDTGDRLLTPGEVAALFRVDPKTVTRWAAAGRIGSIRTPGGHRRFRESEVRALLEGEGMLDEVDEVGTDRPRNAGPAAAGSPGPTNAGLY
>NZ_CP022961.1|WP_095563345.1|407096_407555_+|Lrp/AsnC-family-transcriptional-regulator
MDAIDRSLVDLLRGNARLSYAELARQVGLSAPAVHERVGKLEAAGVIRAYRADIDPEAIGLGVTALIGIVQDSGGDTDDVLAAFREMPEIESCYFMAGVESFLLKARVGTIAELERLINQLNRTPGVASTRTGIALSTKWENRPQPLIPPAE
>NZ_CP022961.1|WP_095563346.1|407609_408701_+|PLP-dependent-cysteine-synthase-family-protein
MTHVDRCNEADRAWVTAAIATVDADANRSADTHLLPFPLPPEWGIDLYLKDESVHPTGSLKHRLARSLFLYGLCNGWIGPQTTIVEASSGSTAVSEAYFARMLGLPFIAVMPASTSPEKISLIEFQGGRCHLVDDPAKVVIEARWLAEDRGGHFMDQFTYAERATDWRGNNNIAESIYHQMTLERFPVPAWIVVGAGTGGTSATIGRYVRYRRLATKICVVDPEQSAFYPAWATADWSVSTGRGSRIEGIGRPRVEASFVPSVVDRMTQVPDAASLAAMRAASRVLGRLIGGSTGTNLWGAFALIAEMRAAGRTGSLVTLLCDGGERYADSYYSDEWVARQGMDLAPHLSAVEKFLATGAWDG
>NZ_CP022961.1|WP_095567491.1|408837_409452_-|hypothetical-protein
MPISLFWTRTDTTGSDHSLLDDRGGLTARGVAQAVRPVDHTCRYELRTDENWATVSLEVSAEGAGWLRSVRLDRAGGRWRITTGETGDLDAALARAGRPAAGLPGTDDPDRLAEALDVDLGAAPLFNTLPVRRLGMLDAEPGTSHRLTVAWVLVPSLLVVPTEQVYTALGAGRVRYASGTFTADLELDEHGYVRNYPGLARLAE
>NZ_CP022961.1|WP_157756565.1|411590_413210_-|hypothetical-protein
MDEDQVPPGTAAVADREQRSRPDTGAERDGRPVDASPSRPAATARSDGPTGPGTGQPVQGRAAVAVRAKASVPAHPAGPTTGTPAADGSPTGERPRVPAQRRPVEDDLAATRAAATDAPPAELTVEPAGPTVEPAGPTVEPAGPTVEAPATPIEPASATEPAPPDPARPSEPPEPGPEPAPTPVPVPEPAPVPEPVPEPAPVPTPPGPAPTPPGPTPPGPLPDPIPPAPTPPGPPGPVPPGPVPPTPQPFPPAPPAPAPPGPMPAPPFPPPPAMGRAGMTTPPPAATGGAGRPAAAGIPTGAEETQVVRIGTARTTSNPTDTDQTQVIRTGTARTTSNPTDTDQTQVIRTGTARTTSNPTDTDQTQVIRTGTARTTSNPTDTDQTQVIRASVPRATSASADADQTQVIRQRPVGKVGGRPGPAGGFDGGATQVVPTPPAGQHGWSRPGGGYGGYGGYEQSDLGQRTVPVLPPSVENSGSLTGHILAQGWSDAPAQRDNGTAKVVIVLAVGLGVVVLVGLLVAAVLADAFRSIFGGALGN

Crispr_ID: NZ_CP022961_4

• CRISPR_ID: NZ_CP022961_4
• CRISPR_location: 439942-440036
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_4

Consensus_repeat	Method
CCGCCGGCGGCCGGCCGAGCGTCGAC	CRISPRCasFinder

spacers of NZ_CP022961_4

>4.1|439968|43|NZ_CP022961|CRISPRCasFinder
CCTGCGGCCACCAACCCGGCGACCGGCGGCACCAACGCCGCGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_4

CRISPR arrays

The CRISPR arrays of NZ_CP022961_4

>merge|NZ_CP022961|4|439942-440036|CRISPRCasFinder
CCGCCGGCGGCCGGCCGAGCGTCGACCCTGCGGCCACCAACCCGGCGACCGGCGGCACCAACGCCGCGGCCGGCGGCGGCCGGCCGAGCGTCGAC

>NZ_CP022961|4|4|439942-440036|CRISPRCasFinder
CCGCCGGCGGCCGGCCGAGCGTCGAC	CCTGCGGCCACCAACCCGGCGACCGGCGGCACCAACGCCGCGG
CCGGCGGCGGCCGGCCGAGCGTCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095563359.1|432861_434550_+|HNH-endonuclease	unknown	unknown	gnl|CDD|367155
NZ_CP022961.1|WP_095563368.1|446443_446875_+|hypothetical-protein	unknown	unknown	gnl|CDD|237537
NZ_CP022961.1|WP_095563361.1|435969_436908_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563365.1|443996_445232_+|cell-wall-anchor-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563358.1|431094_432756_-|TIGR02677-family-protein	unknown	unknown	gnl|CDD|378233
NZ_CP022961.1|WP_095563362.1|436907_437861_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563370.1|448388_448754_+|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl|CDD|181171
NZ_CP022961.1|WP_095563367.1|445494_446238_+|demethylmenaquinone-methyltransferase	unknown	unknown	gnl|CDD|234689
NZ_CP022961.1|WP_095563372.1|449448_450183_+|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl|CDD|181115
NZ_CP022961.1|WP_095567494.1|439518_439776_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B	unknown	unknown	gnl|CDD|237504
NZ_CP022961.1|WP_095563369.1|447001_448276_+|geranylgeranyl-reductase-family-protein	unknown	unknown	gnl|CDD|273936
NZ_CP022961.1|WP_095563371.1|448768_449452_+|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl|CDD|235797
NZ_CP022961.1|WP_095563363.1|438232_439324_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A	unknown	unknown	gnl|CDD|184320
NZ_CP022961.1|WP_095567493.1|424153_425461_-|DUF2399-domain-containing-protein	unknown	unknown	gnl|CDD|274255
NZ_CP022961.1|WP_095563357.1|425453_429575_-|TIGR02680-family-protein	unknown	unknown	gnl|CDD|274256
NZ_CP022961.1|WP_095563360.1|434851_435721_+|menaquinone-biosynthesis-protein	unknown	unknown	gnl|CDD|270352
NZ_CP022961.1|WP_095567495.1|440755_441226_+|phenylacetate-CoA-oxygenase-subunit-PaaJ	unknown	unknown	gnl|CDD|131214
NZ_CP022961.1|WP_095563373.1|450179_451508_+|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl|CDD|180385
NZ_CP022961.1|WP_095563364.1|442430_443636_+|dehypoxanthine-futalosine-cyclase	unknown	unknown	gnl|CDD|274731
NZ_CP022961.1|WP_095563356.1|423870_424083_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095563359.1|432861_434550_+|HNH-endonuclease	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	5.22972e-19
NZ_CP022961.1|WP_095563368.1|446443_446875_+|hypothetical-protein	gnl|CDD|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	0.00591603
NZ_CP022961.1|WP_095567494.1|439518_439776_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B	gnl|CDD|237504	PRK13781, paaB, phenylacetate-CoA oxygenase subunit PaaB; Provisional.	1.77192e-57
NZ_CP022961.1|WP_095563358.1|431094_432756_-|TIGR02677-family-protein	gnl|CDD|378233	pfam09660, DUF2397, Protein of unknown function (DUF2397). Proteins in this entry are encoded within a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).	1.11329e-112
NZ_CP022961.1|WP_095563370.1|448388_448754_+|NADH-quinone-oxidoreductase-subunit-A	gnl|CDD|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	4.91618e-70
NZ_CP022961.1|WP_095563367.1|445494_446238_+|demethylmenaquinone-methyltransferase	gnl|CDD|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	2.33962e-112
NZ_CP022961.1|WP_095563372.1|449448_450183_+|NADH-quinone-oxidoreductase-subunit-C	gnl|CDD|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	3.4388e-137
NZ_CP022961.1|WP_095563369.1|447001_448276_+|geranylgeranyl-reductase-family-protein	gnl|CDD|273936	TIGR02032, Uncharacterized_protein_MJ1520, geranylgeranyl reductase family. This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	1.69743e-79
NZ_CP022961.1|WP_095563371.1|448768_449452_+|NADH-quinone-oxidoreductase-subunit-B	gnl|CDD|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	2.0519e-102
NZ_CP022961.1|WP_095563363.1|438232_439324_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A	gnl|CDD|184320	PRK13778, paaA, phenylacetate-CoA oxygenase subunit PaaA; Provisional.	0
NZ_CP022961.1|WP_095567493.1|424153_425461_-|DUF2399-domain-containing-protein	gnl|CDD|274255	TIGR02679, conserved_hypothetical_protein, TIGR02679 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	1.60772e-38
NZ_CP022961.1|WP_095563357.1|425453_429575_-|TIGR02680-family-protein	gnl|CDD|274256	TIGR02680, conserved_hypothetical_protein, TIGR02680 family protein. Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved].	1.55643e-145
NZ_CP022961.1|WP_095563360.1|434851_435721_+|menaquinone-biosynthesis-protein	gnl|CDD|270352	cd13634, PBP2_Sco4506, The conserved hypothetical protein SCO4506 exhibits the type 2 periplasmic-binidng protein fold. This group includes the SCO4506 protein from Streptomyces coelicolor and related hypothetical proteins. SCO4506 is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. SCO4506 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.05442e-107
NZ_CP022961.1|WP_095567495.1|440755_441226_+|phenylacetate-CoA-oxygenase-subunit-PaaJ	gnl|CDD|131214	TIGR02159, Putative_12-phenylacetyl-CoA_epoxidase_subunit_D, phenylacetate-CoA oxygenase, PaaJ subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	4.70658e-59
NZ_CP022961.1|WP_095563373.1|450179_451508_+|NADH-quinone-oxidoreductase-subunit-D	gnl|CDD|180385	PRK06075, PRK06075, NADH-quinone oxidoreductase subunit D.	0
NZ_CP022961.1|WP_095563364.1|442430_443636_+|dehypoxanthine-futalosine-cyclase	gnl|CDD|274731	TIGR03699, menaquin_MqnC, dehypoxanthine futalosine cyclase. members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0

Protein sequences

>NZ_CP022961.1|WP_095567494.1|439518_439776_+|1,2-phenylacetyl-CoA-epoxidase-subunit-B
MFVRARRGLSHSHVGSLHAPDAELALRNARDLYTRRQEGVSIWVVPAAAITASSPDEKDAFFDPAADKVYRHPTFYEVPDGVAHL
>NZ_CP022961.1|WP_095563363.1|438232_439324_+|1,2-phenylacetyl-CoA-epoxidase-subunit-A
MYGNDFSQPEEAPTGALLDQVEAAEAELRDAAARARAGASGTAGAAPEEYFDSVIAADQKIEPRDWMPERYRRTLVRQIAQHAHSEIIGMQPEGNWITRAPSLKRKAILLAKVQDEAGHGLYLYAAAETLGVDRDELVDLLLSGRQKYSSIFNYPTLSWADVGAIGWLVDGAAIVNQVPLCRCSYGPYARAMIRVCKEESFHQRQGYEILHTLAHGTPEQRTMAQDAVDRWWYPSLAMFGPPDTDSTHSAQSMEWKIKRFSNDDLRQRFVDMCVQQAEVLGLRIPDPALRWNAERQAYDYTQPDYDELMRVISGDGPCNRQRMDHRRRAHAEGAWVREAAVVHAAKRAERAEQAAARKDPVAA
>NZ_CP022961.1|WP_095563362.1|436907_437861_-|hypothetical-protein
MRPRVIMVLAIVAILLGGVMLVPAAYARFSGGDGPLGLRLAGSAPKPPTPTAPEPASLAYQPVSVTGYKGSFLAWAIMDRDSGEISGSSNISSTNSTESMIKAWLVSDYLRRLGDKEPPASMLKKASTAIRDSDNIAAENLYNAGGRLPVIQRLISICGLTDTKAESSSRHKWAYTQMSPRDAVRMGDCIASGKAAGPKWTEWVLNEMAHVRGTTAAKDQHEQTGGGHWGIVDGLPKSITSEGPVHIKNGWTMLFADYQWHLNCLAVTDKWSLAVMMRYSGKISLQYGASVCASVTSQLVTPEPGAALQVPTPLAKA
>NZ_CP022961.1|WP_095563361.1|435969_436908_-|hypothetical-protein
MGEYRGSRRRPGDRTPLRLVLFSVVLLAAVLAGLRFIPGSPFATKSVAQWGHAARTDSAADAPASRSDRPSPSPSPELPPLPIAPADIKINATGWWSWAMQDTRTGKIYGSKNLGETNTTASMIKSWIAADYLRRSAEKGVTPSSARMAQVSTMIRDSDNEAAQSLWLAIGGAPAIDRLIDICKLTDSSGYKNLWSNTRLSPRDITRLGACIADGRAAGPKWTDYLLNEMRHVRGTGDFGVRKAFPASDQKDIAIKNGWVDRQATQEYHVSCLAIGDGWTVGVMARYPINLDYSYGAKICENVGRQLIAAAK
>NZ_CP022961.1|WP_095563360.1|434851_435721_+|menaquinone-biosynthesis-protein
MAGYGRFVTELRRPRVGHIQFLNCLPIYWGLVRSGALLDVDLYKDTPDHLNDRLVAGGLDIGPISLLEYLRHADELLLLPDLAVGSDGPVLSVNIVSTRPPAELDGARVALGSTSRTGVLLAQMLLGERYGARPEYFRCPPELSQMLLEADAGVLIGDVALRALYEAPARGLTVTDLGQAWRDWTGLPMVFAVWAVRRDFAAAHPGQVKEVHEAFLRSRDLCLAALDEVATAAARWEPFDAATLANYFRALDFSLGGRQVDGLREFARRAAALGAAPALPADGPAFFQV
>NZ_CP022961.1|WP_095563359.1|432861_434550_+|HNH-endonuclease
MSSMSRCSPSGGAGGCRILWSKASYVRSTVRIVIDAAERVVGAARECAARPVWSASNAALIAALEAVHRAERLLTVAKLAAVREIDGRDLGRAQGATSTAGWLRDRLRISPTTARQLVADAAWMDADDATDHAVRPDPPADPGSGTPGCGVDAAGCGSTAAGCGADAAGPALRAALTSGDISLTQARIIAGAVTAARAEAGPPVADKALHALLGHARDLAPAALRVCAERILWHVAPEAAEEADRRALRRQESRAEQRRDLTLSIAAEGWLRLRGVLDAETGALLTAALDPLVRPNGPGDDRGPGQRRHDALAEVLHLALRTGELPDNGGEPPQLVITTSFDALTARLGSGTAHRSGTTEGVDAHGAGASQGVDAHGSGTTHGSGTAEGVDARGSGTTQGVDAHGSGTHGPGVALGAGPGFGVGTLDTGLRLGPDALRRLACDAAILPAVLGGRGQVLDVGRQRRLFTGPLRRALVLRDRGCAFPNCDRPPRWCAGHHIRPWTDGGGTSLHNAVLLCGYHHRVIHRGEWIVRLARDGHPEFIPPYWLDPDRTPRRNRYHLRC
>NZ_CP022961.1|WP_095563358.1|431094_432756_-|TIGR02677-family-protein
MPQPRVQSFGLDDFALDDRLRLFSYLTADNRIGYLWLLRAIESARNSYHLVLHTSEVAAALAGLAETQPDCPDPAGLELPRLLDALVDWGVLDRGQDGARATSLAEYRNRHSVYQFTEAGYRAHRAVESVLSASLNDSTLSRLVFADLLADLQALAVANAAGDAEEVYRKLSRLDRALADIAERAARFYHMLGDLGRTHDVRPEVFLAHKDALLSHLRDFYDELQRYTPRLREAVREVETTGLDRLVEAAAEADERVFGTPVERLDDWRRRWSGLRSWLAPPSADLPSEADRLAGATTAAIGDVLALLRRITEARRGGVSRESQLRHLAAWFTAAGSVDAAHALFDAVFGLGAPRHAGVAHPDPEAIPTRLSWWDAPAVELSRTLVQFGRTPGQGNGRPARIDRSASERHRLREHQLAEERRHVEAAARLAEAGPAAIGPDGAPRAGTDQDGTDQSGAEFSPDAGTDPAEPLDDAQVAVLRRLLDVALAARAPGRPDTPLVAAAFGVRLTLSPAPGRFTTVRTAGGWLHLDGYALTVAPARHTVAQRRELVPA
>NZ_CP022961.1|WP_095563357.1|425453_429575_-|TIGR02680-family-protein
MARFRPTRAGIVNLWDYRDEEFLFVDGWLVLRGPNGSGKTKALEVLFPFVLDGRIEPRRLNPFAGEDRTMKSNLLYRGQESAHGYVWLEFGDGSSYVTIGIGLRAHRHNDRVTRWHFVAEGRVGVELSLLDADDRPLVRKDLAAALGPDAVRDSAEEYRQLVDARLFGLGPARYEQLLDLVLTLRKPQLAKDLNPAELSRTLQRGLRPLDDHLVVEAARSFDDMEAVARTLEGLVAADGASTAFLNVYATYLRTHARAAADALSARRTAVNGRSGELAAARERAAEAAGATERAEAQLRAAESEPGRLRAHLDRLKGSAAYRSHEQLADLERHVHDLAEAAERSGTAVAAERSVLERRRAESERAEQSARDARGQLARLAEEIAADARTGGVPWSGADAAADGLAARIVARSTARRDDLRAVRAGADRLTQAQRDHESAAGADRTARTQVEEATAAEEQAGTVVQVARERAAAAVRDWGRRYASLLAGLDRPGLVEELAAAVDAPSLREAYAEAVAAPLTARRDTAAALAARYDADAARRAELAAERDRVAAERDDDPAPAPTRPASRDGRAGGPLWRLVRFADAVPEREAAAIEAALHAAGLLDAWLYPGEAETAAAVAAGEQDGYLRTTDPVAGASLADVLVPEERSAVPADRVRAVLASIALDDLSAGSGVDRTGRWTLGVGTGRLGKDRCEYIGATARAVRRAERVAGFDRRLAEADAGLARIADERAAVLAVLAEAEQAAGALPALTEIQQARREHDRAAAALRVRQEAAIAAAGRLDAAVAERASADAALRRLVADRALPVDRLDPTAEAVDRFERVGVRIEAAHSAADTAAEVAAAAADRLAEAAQRLDTAEAAAREATRRHAEKAEELRTLRGAIGAETEQVLADVARTDAEITAAEAGLAAARDRYTDAAREGAAALARVELGERAVADALREARQDALRLRPYAQPDLLGLIRCPTRLRWPELESPGDELDPAVVALHEAVLGATRELSPTETSLKQSATRLTTALAELQAQLPATGLDHRPEWDTDDGVIVVRVVDEQGPTPVARFAQRIAAERRDQEQLLTDAEQRVFEDALLGQLAGQIHRRTIEARDLVAGMDAQMRRRRMSSGLTVGVGWRLSDDLDPDQRDVCKLLERDPARLGPAQLTGMRGHFASRIKAARSVAPEKPYRELLAEVLDYRQWRVFAFTLHRPGGTAEPLTRARHSQLSGGEQSVSLHLPLFAAANALFDSARPDAPRLLGLDEAFAGVDETGRGELMSLAKQFDLDLFMTGYDLWATHPAVTGAAHYDLSHSAPDHTVSAVLLVWDGAMNVADFDGTLARSLGSPETRRAPVPADRVPAGAGLDGAGLDGAGLDGADPSGAGLDG
>NZ_CP022961.1|WP_095567493.1|424153_425461_-|DUF2399-domain-containing-protein
MADPGLSGAADPGDPRPGPPAGPAAGPAAGPAAGPPADAGWRRLLAAARRSLERTGGSLAGTVSLAAPSEAERLTVIGITGVHRPAGTTRLTVRLADLDEHLRAAYGLGLADLLGAIRDRPAERRRAAVDRDAVLSRAAASRHSDAAWYADWLDGLRRDGTLTRVVRTGLDFGRVVAVLDALPAADEPLPAFAERLLGDTKALADGPLRGLVLRALAAWHAVPTPSGAERERALWELAGLVPDDLASQALVLNLPATGGLLGGWLTGAAAAGVPFRVTLHQTRLAPLILDRTEIFVCENPAVLRAAAARGSRPLICTEGVPSAAVHALLRAAPPGAVIRWRNDFDWTGVRVTAAALARYPTAVPWRMSAADYADHAAGGGAGGALADGAGVALAGSPAPTPWDPALRSAMLDTGRAVMEERLLPLLLDDLAPPGR
>NZ_CP022961.1|WP_095563356.1|423870_424083_-|hypothetical-protein
MLVVLDEAPRLTGGHTDFADTVSAVWENHIRNQRLLLVLSGSAVTVMEQMLGPQGGRTRATAGRVRRSGP
>NZ_CP022961.1|WP_095567495.1|440755_441226_+|phenylacetate-CoA-oxygenase-subunit-PaaJ
MDQARAAVAAVVDPEIRAVTIEELGILRDVTVRDGRVVVSITPTYTGCPAMDVIRGDIRTALAAAGCPDAEVRTVYAPAWSTDWITEAGRTKLASAGIAPPDPVRRAGPVPLTLTARCPRCGSPDTEQLSRFGSTACKSLWRCRACREPFDHLKAL
>NZ_CP022961.1|WP_095563364.1|442430_443636_+|dehypoxanthine-futalosine-cyclase
MTVSREIDDILRRGADGGRITPEEALLLYTDAPFHALGEAADAVRRRRYPDGIVTYIIDRNINYTNVCVTACRFCAFYRAPKHREGWTHPTDEILRRCAEAVDLGATQVMLQGGHHPDYGVEYYEELFSSVKRAYPQLVIHSIGPSEILHMAKVSGVSLEEAITRIKAAGLDSIAGAGAEMLPQRPRHAIAPLKESGERWCEVMALAHRLGVESTATMMMGTGETNAERIEHLRMIRDVQDRADQGGYGGFRSFIPWTYQPENNHLKGRTQATTLEYLRLVAVSRLFFPTIPHLQASWLTTGKEAGQLALHMGVDDLGSIMLEENVISSAGARHRSNLHQLIDMIRSAGRIPAQRDTLYRHLRVHWTPADDPTDDRVVSHFSSIALPGGGVGRRLPLVEAS
>NZ_CP022961.1|WP_095563365.1|443996_445232_+|cell-wall-anchor-protein
MTFRSLSRPVRLGAAALLAAGGLLALGAPAYAADKADLAIVPSSFQLARSGTEAARKPFKFTVVNQGPAAATEVTVAIDYAGLDDALVAWSPPTGCAHSGAVYTCRLGLLSTDGADDVPAGARAEFGLPIWSIGKKGDAGSLTVTVASATPDPVKRNNEAEVPVTVVKAGYDLTTWASDVHVPVTAGAGTPGAATPLDWFVHNAGSKQAVGLTYILNLPAGAHFASVPPECVQQATTLDVYYCTVPDLVLRPQDVYTAPVTVTVDPGSTARLPDPGQVAAEASGTDAPDARRLSGQRYGKQATAAQLADVDDGDNIANFDIFAELVTATPSPEPSGEVTPTPSGSAAPVSPAPSGAPEAPGTGGGLPVTGAQVGLIGGVGAAVLALGGLLFVLSRRRKVVLVTPEDERSGE
>NZ_CP022961.1|WP_095563367.1|445494_446238_+|demethylmenaquinone-methyltransferase
MPVRTLAEWFTVKHASTGQRAGLDKQPHEIAAMFDGVASRYDLTNTVMTAGRDRAWRRATRAALDLRPGELVLDVGAGTGVSTEELARSGAYAVGADLSLGMLAAGKRDRPDVPLLAGDALRLPFPDATFDAVTISFALRNVADTTAALREFARVTRPGGRLVICELSHPVNRAFRVAYLSYLMRWLPAAARVVSSNPDAYVYLMESIRAWPDQAGLAALVRAAGWGNVAWRNLTGGLAALHRAVRD
>NZ_CP022961.1|WP_095563368.1|446443_446875_+|hypothetical-protein
MTESDRRGEPLAGAGGSAHNGAAAGNSAAHNGAAAGNSAAHNGAAGGNSAAHNGAAAGNSAAGNSAAHNSAAGGNDAADLADQLRELAGSDPAAVQQVVAEVLAALDRASGGALRDQLPGALDRQPGAGDPATDRPEGPAESD
>NZ_CP022961.1|WP_095563369.1|447001_448276_+|geranylgeranyl-reductase-family-protein
MTVENDADVIVVGAGPGGSTTAYHLARHGLRVLMLEKTEFPREKVCGDGLTPRAVKQLISLGIDTSAEAGWLHNRGLRVIGGGVRLELDWPDLASFPNYGLVRPRLDFDDLLARQAVKAGAELRTGMNVIGPVLDDAGRTVGVTAEHGPDKAPVSFHAPLVVAADGVSGRFPLALGLTKREDRPIGVAVRRYYRSPARQHDDYLESWLELRSRDSGDKLLPGYGWIFGMGDGRVNVGLGLLNSSSAFGRTNYRRLLTDWLASTPPEWGMSDEANAEGPILGAALPMGFNRVPHYTRGVLLVGDSGGMVNPFNGEGIAYAMESGELAAEVIVQALARPAGAERERALHGYPAALSSRYGGYYRLGGLFVKLIGRPEIMRIATRHGMPHPTLMRFVLKLMANLTDPRDGDAMDRIINAMTKVAPAV
>NZ_CP022961.1|WP_095563370.1|448388_448754_+|NADH-quinone-oxidoreductase-subunit-A
MSLSPYVPIIGLFAVAAAFALFSVAAARFAGPRRYNRAKLDAYECGIEPSPEPIGGGRFPIKFYLTAMLFIVFDIEIIFLYPWAVSFDLLGAFGFVEMVLFIVAVFVAYAYVWRRGGLDWD
>NZ_CP022961.1|WP_095563371.1|448768_449452_+|NADH-quinone-oxidoreductase-subunit-B
MGIEEKLPAGILLTSVEKLVNWSRKSSVWGATFGLACCAIEMMAAGGPHYDMGRWGMEVFRASPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPRWVLSMGVCASSGGMFNNYAIVQGVDHVVPVDMYLPGCPPRPEMLIDAVLKLREKIMYEPLGPGGRKMLAARTERGDVPVVPYGSMPSSYRSDKARRAEWTQAVREGREEQLRIENWMKAQNHLHQHEGTVNR
>NZ_CP022961.1|WP_095563372.1|449448_450183_+|NADH-quinone-oxidoreductase-subunit-C
MTAPSEKPGAGVPATSPPIGANTGAPADYPPASPAQRGLFGVHGSGDTSGFGGLVRPHVDVDGSQRPYGGYFDEVTDALEEAYPAFADAIEKVVVDRGELTLHIQPGRIAEVCQVMRDDAALRFELCSSVSGADYLGVDERRLHVVYQLTSMTYRRRVRLEAAVSAEDPHLPSVTAVYPTADWQERETYDMFGVVFDGHPNLTRVLMPDDWEGHPQRKDYPLGGVPVEYKGAEIPPPDARRSYQ
>NZ_CP022961.1|WP_095563373.1|450179_451508_+|NADH-quinone-oxidoreductase-subunit-D
MTSTPGYATERETAEGRVFTVTGGDWDTVVEGTDPIAQERIIVNMGPQHPSTHGVLRLILELEGETVREARSVVGYLHTGIEKNLEYRNWVQGSTFVTRMDYLAPIFNETAYSLAVEKLLGITDEITDRANTIRVLMMELNRLSSHLVWLATTGMELGAISIMLYGFREREFILDIFETITGLRMNHAYVRPGGVAQDVPDEAIVKIREFLKMMPKRLKEYEDLLSGQPIWVERTKGVAVLDVTGCVALGVTGPVLRSAGLAWDLRKTMPYCGYENYEFDVPTHPDGDVWGRYQVRLAEMRESLKLVEQALDRLKPGPVMVADRKIAWPAQLAVGLDGMGNSLEHVAKIMGQSMESLIHHFKLVTEGFRVPAGQVYVGIESPRGELGVHAVSDGGTRPYRVHYREPSFVNLQAIPALAEGGLIADVIAGGASLDPVMGGCDR

Crispr_ID: NZ_CP022961_5

• CRISPR_ID: NZ_CP022961_5
• CRISPR_location: 472713-472794
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_5

Consensus_repeat	Method
TTGCCGGCCTGGTCACGCTTGCCGGCC	CRISPRCasFinder

spacers of NZ_CP022961_5

>5.1|472740|28|NZ_CP022961|CRISPRCasFinder
CGGTCACGCGTTGCCGGCCTGGTCACGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_5

CRISPR arrays

The CRISPR arrays of NZ_CP022961_5

>merge|NZ_CP022961|5|472713-472794|CRISPRCasFinder
CGGCCGGCTCGGTCACGCTTGCCGGCTCGGTCACGCGTTGCCGGCCTGGTCACGCTTGCCGGCCTGGTCACGCTTGCCGGCC

>NZ_CP022961|5|5|472713-472794|CRISPRCasFinder
CGGCCGGCTCGGTCACGCTTGCCGGCT	CGGTCACGCGTTGCCGGCCTGGTCACGC
TTGCCGGCCTGGTCACGCTTGCCGGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095563392.1|478053_478992_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP022961.1|WP_095567499.1|469646_470579_-|EamA-family-transporter-RarD	unknown	unknown	gnl|CDD|225510
NZ_CP022961.1|WP_095563387.1|471325_472708_+|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288
NZ_CP022961.1|WP_157756566.1|479086_479614_-|hypothetical-protein	unknown	unknown	gnl|CDD|184918
NZ_CP022961.1|WP_095567500.1|475301_477557_+|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP022961.1|WP_095563395.1|479712_482115_-|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|368494
NZ_CP022961.1|WP_095563380.1|461723_463256_+|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl|CDD|235622
NZ_CP022961.1|WP_095563390.1|473834_475142_-|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl|CDD|274856
NZ_CP022961.1|WP_095563386.1|470773_471160_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377198
NZ_CP022961.1|WP_095563388.1|473075_473393_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NZ_CP022961.1|WP_095563383.1|466137_467370_-|MFS-transporter	unknown	unknown	gnl|CDD|341028
NZ_CP022961.1|WP_095567498.1|468416_468932_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236605
NZ_CP022961.1|WP_095563385.1|468928_469627_+|zf-HC2-domain-containing-protein	unknown	unknown	gnl|CDD|379219
NZ_CP022961.1|WP_095563397.1|484764_485595_+|oxidoreductase	unknown	unknown	unknown
NZ_CP022961.1|WP_095563384.1|467525_468308_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|224332
NZ_CP022961.1|WP_095563381.1|463252_464809_+|NADH-quinone-oxidoreductase-subunit-NuoN	unknown	unknown	gnl|CDD|235603
NZ_CP022961.1|WP_095563382.1|464923_466000_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|223220
NZ_CP022961.1|WP_095563391.1|477553_477919_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563389.1|473415_473709_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NZ_CP022961.1|WP_095563396.1|482450_484556_-|acetate--CoA-ligase	unknown	unknown	gnl|CDD|234677

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095563392.1|478053_478992_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.67094e-23
NZ_CP022961.1|WP_095567499.1|469646_470579_-|EamA-family-transporter-RarD	gnl|CDD|225510	COG2962, RarD, Predicted permeases [General function prediction only].	1.41312e-94
NZ_CP022961.1|WP_095563387.1|471325_472708_+|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	2.05572e-72
NZ_CP022961.1|WP_157756566.1|479086_479614_-|hypothetical-protein	gnl|CDD|184918	PRK14954, PRK14954, DNA polymerase III subunits gamma and tau; Provisional.	0.000465904
NZ_CP022961.1|WP_095567500.1|475301_477557_+|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	6.32897e-16
NZ_CP022961.1|WP_095563395.1|479712_482115_-|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	0
NZ_CP022961.1|WP_095563380.1|461723_463256_+|NADH-quinone-oxidoreductase-subunit-M	gnl|CDD|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	0
NZ_CP022961.1|WP_095563390.1|473834_475142_-|type-VII-secretion-associated-serine-protease-mycosin	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	1.90819e-80
NZ_CP022961.1|WP_095563386.1|470773_471160_-|phage-holin-family-protein	gnl|CDD|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	7.33437e-15
NZ_CP022961.1|WP_095563388.1|473075_473393_+|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	5.38472e-11
NZ_CP022961.1|WP_095563383.1|466137_467370_-|MFS-transporter	gnl|CDD|341028	cd17475, MFS_MT3072_like, Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily. This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.28195e-20
NZ_CP022961.1|WP_095567498.1|468416_468932_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236605	PRK09645, PRK09645, ECF RNA polymerase sigma factor SigL.	8.90505e-72
NZ_CP022961.1|WP_095563385.1|468928_469627_+|zf-HC2-domain-containing-protein	gnl|CDD|379219	pfam13490, zf-HC2, Putative zinc-finger. This is a putative zinc-finger found in some anti-sigma factor proteins.	2.56347e-05
NZ_CP022961.1|WP_095563384.1|467525_468308_+|helix-turn-helix-domain-containing-protein	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.31778e-24
NZ_CP022961.1|WP_095563381.1|463252_464809_+|NADH-quinone-oxidoreductase-subunit-NuoN	gnl|CDD|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	2.75682e-176
NZ_CP022961.1|WP_095563382.1|464923_466000_+|polyprenyl-synthetase-family-protein	gnl|CDD|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	8.37648e-86
NZ_CP022961.1|WP_095563389.1|473415_473709_+|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	7.39814e-13
NZ_CP022961.1|WP_095563396.1|482450_484556_-|acetate--CoA-ligase	gnl|CDD|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0

Protein sequences

>NZ_CP022961.1|WP_095563387.1|471325_472708_+|type-VII-secretion-protein-EccB
MPARQDQLHSYQFVVQRMVAALVVRETDPARSPFRRSASAALAGLLVAGIGLGVAALYGVATGGADQYRDGTAVIVERETGARYVYRGERLHPVLNYASALLIVGSAEPRTVLVSRRSIRDVPRGTPLGLAGAPDSLPGADRLTGQGWAVCSAAADATGAAPASVVRVGRPPLGRPLGDAGVLARHPDGSLHLLWHGRHHLIRDPDLVLAAFAWSSRRAVPVAPALLAALPPGADLAPVPLSGSGRPSRVPGAAVGEVFVVQTQGGARQYAVAAADGLATITALQADLLLTAGGQAEPTVLAQGRFAAAPKRPDLVPQGGMAPPASAPDLVDTGGATLCGRIEPGSAGPPELRIDAGEPGAADGVDAGPHPAGEVRADRVAVPAGGGAVVRAMPAPGASGGAVCVVTDLGRRYAVPDPDVLAMLGYRDVRPVELPAAVLALLPPGPVLEPQAARSPAPGP
>NZ_CP022961.1|WP_095563386.1|470773_471160_-|phage-holin-family-protein
MGFLKGILVRLVTTAIAFWLATLVIPGIDLTTDSNVDKVTTLLLVAIIFGVVNGVLHPIIKTVGCGLYLLTLGLIALVVNGLLFLLTSWIAGQLDLPFHVEGFWPAGVLGALFVGVVTWVLGLIMDRD
>NZ_CP022961.1|WP_095567499.1|469646_470579_-|EamA-family-transporter-RarD
MTELGRGYLYGFAAYALWGFYPLYIKLLRPSGPVEILAHRVVWSVVFVALVLAALRNWGFLRRLFARPRAVAGIAVAATLIAVNWGTYIYGVNSDRVVETALGYFINPLVVVLLGVTVFRERLRPAQWVALGLGALAVAVLTVDYGRLPYLALTLAFTFSGYGLVKKRLALPAAEGLFAESAMLALPALAYLGWLQWRGTGTFGHGPLPHSGLLVLAGAATAVPLLMFAGAANRLPLTGLGMLQYLTPVLQLGCGILVFHEPMPPARLVGFALVWLALIVFTVDGLRTARRRSRIVPLAGTAPEAAAATP
>NZ_CP022961.1|WP_095563385.1|468928_469627_+|zf-HC2-domain-containing-protein
MTSCEFIYDDGAYVLGALAPAERAAYERHLAGCAECREAVAEIAVLPGLLGRLDPAGLESIAGPPEPQSRLPGLIAAARADRRRSRRRTRMRYAGAVLAAAGLALVFGLGVTRLAGDAARPAPSASTVPLAAMRPVRGAGPVTAEVAVTSTAWGSRVTMHCRYPATGDYPETRTFRLVAIGADGAREQVSSWLAAPGDDVTLTGATRLSGPELTRLELQRQDGTPLLGYDVR
>NZ_CP022961.1|WP_095567498.1|468416_468932_+|sigma-70-family-RNA-polymerase-sigma-factor
MSDLDAQLLRALHDEHADALFAHALRLVGGDRQRAEDLVQETLLRAWRHPEALDPGRGSVRAWLFTTARNLAIDAWRRRSSRVGEVVTDNLPEPPQGPDEADRAVEAWTVAEALGRLSPTHREVLVECFYLGRSVAEAAARLGVPPGTVKSRTHYALRSLRLVLAEMGVTR
>NZ_CP022961.1|WP_095563384.1|467525_468308_+|helix-turn-helix-domain-containing-protein
MRDPLAEPSDLIRSVSRALRVLEAVGRAPKGLTVKQIARRCELTVATTYHLVRTLAYEGYVIRREDGTYIVGLEVADRYRELVTAFRGPPPVGEALRRAAVETGYSHFLGRFVGGQVAISAVAEGPRSPYLEDLVPGFDEGAHATALGKALLATLTPEQRLRYLREFGMRPFTPATLTGAEAFEADIAAGDRRGMQVEMGQFRQGVACAAVLVTPEKEMERRVVLACALPAAEMMTSARIVRAKLIAVARSVADGLATEA
>NZ_CP022961.1|WP_095563383.1|466137_467370_-|MFS-transporter
MTTADRRSPRSASGRPVQPVRVAAGAVATTVACVVPVFLVGGLAVQMGHELRFSPAGLGLAVSVYFGVSALASVPSGTLVERYGPAVVARSGILLAAGALLAIGLLARSYALLVLLLAISAGANALGQLASNMSLARHVPAGRQGLSFGVKQAAIPISTLLAGAAVPTVALTVGWRWAFVVAAVAALTALPAVPPDGRGRIARAERSGGRATVALAVLGLAGALASGAANALGTFVVDSAADRGLSPGLAGLTLTFGSAVCVLARVGSGWLADRRASGHVAVIAGMLVVGAAGLGLLAVAGVPSMVAGITLGFGLGWAWPGLLNFAVVRLHPQAPAAATSITQTGVYAGGCVGPLGLGAVAGHLGYPTMWAVAAVSMLVAAGLMLSGRRLLLRVRAAQAAAARPRVAHAR
>NZ_CP022961.1|WP_095563382.1|464923_466000_+|polyprenyl-synthetase-family-protein
MVEDVVRPGEQRAAGAGGQPAGPAAPFEGVGIDLVDPAVEASLRSMLAAVEERLRNTVLSADPMVTEAARHLVEAGGKRFRPMLVGLSAQFGVPDRPEVVTAAAVMELTHLATLYHDDVMDEAPVRRGAQSANSRWTNSVAILVGDYLFARAADLSAELGPEAVRLQARTFARLVHGQIAETVGPRDGEDRVAHYLGVISEKTGSLIATSARFGGLYGGADRHLVEALGGYGETIGMAFQLSDDLLDIASESMQSGKTPGTDLREGVPTLPVLYALASEDRDAASVRLREILAAGPVTDDALHAEALMLLRESPALKRARETVRSYAEDARERLEPLPAGGPRRALESLCDFIADRTG
>NZ_CP022961.1|WP_095563381.1|463252_464809_+|NADH-quinone-oxidoreductase-subunit-NuoN
MSDVKFPAINYSALAPILILFGVACLGILVEAFVPRRLRHPVQLTLGLLGLLAAGAMVLRNVHARTITVGDAVAVDGPTLFLQGSILALGLLALLLIGERSVERGGAFVPHAAVVIDSAADRRQSGGGATEVYPLTMFATAGMLLFVAANDLLTMFIALEVFSLPLYLLCALARRRRLLSQEAAMKYFLLGAYASAFFLFGIALVYGFTVGVSNGRSGQGGVDFATIHAAVRDSSASPVLLFAGIAMVSIGLLFKAAAAPFHVWTPDVYQGAPTPVTGFMAACTKVAAFGGLLRVLYVGFAGAAWDFTPVLGAIAVLTMLVGAVLAVTQTDIKRLLAYSSVANAGYLLVGVLALSKDGLSSTMFYLVAYGFTVLAAFGVVTLVRDDDGEATHLSRWAGLGRRSPLYAGLFTFLLLAFAGIPLTSGFTSKFAVFGAALDGGQTWLVIAGVLTSMLLAFPYLRVVVMMWLSEPGESTPVVTLPGWATGAAVTIGVLATLVLGVAPAPLLDLANGAAEFVR
>NZ_CP022961.1|WP_095563380.1|461723_463256_+|NADH-quinone-oxidoreductase-subunit-M
MSDFPYLSVLTVAPLVGALVVAFLPRTRPDLAKQVAFGWSLAVLVLAIFTWIAFSADGDRLQLRESYTWIPRWGVNFTFATDGIALVMLMLIAVLVPLVILASWHDAEGSKRSVPVYFALLLALECTMIGVFAAADVFLFYVFFEVMLVPMYFLIGSYGGHQRQYAAVKFFLYSLVGGLFMLAAVIGLWVVGGHTFDWQTLLSADINTNTARWLFLGFFVAFAIKAPFFPFHTWLPDAGGAAPAGAAALLVGVLDKVGTFGILRYCLPLFPEASRWFAPWALALAVIGIIYAALLAIGQNDLKRLVSYTSIAHFGFIGVGIFAFTTQAGTGAVLYMLNHGLATGLLFLVVGMLVARRGSAMVRDFGGAGRLVPLLAGVLFFAGLASLAMPGTAPFISEFLVLLGTFTVNKLVAVIATAGIILAAAYVLWMVQRTTQGTLNPALTESADMRRDLTLREKVVVAPLIALLLLLGFYPKPVTDVINPAVQATMQDVGRTDPAPTVGNVQEASR
>NZ_CP022961.1|WP_095563388.1|473075_473393_+|WXG100-family-type-VII-secretion-target
MSQTRAEAEVLRQTAARFERADEALQAMLSGLLTELAGLRQSWRGAGGRSFEQVQQQWSRDQAAIQRALRETAGAIRTAGQQYDSTDGAVASRVSRAGRGIQLPL
>NZ_CP022961.1|WP_095563389.1|473415_473709_+|WXG100-family-type-VII-secretion-target
MHDDQLIVSFPALQQASADIQRAVNTLDAQLAQLERDAAPLVATWEGPAQAAYEQRQTRWRTAAQDLRQMLGEIKVAVDESAADYLSTEKRNASLFQ
>NZ_CP022961.1|WP_095563390.1|473834_475142_-|type-VII-secretion-associated-serine-protease-mycosin
MPSLRTVTAAAVILAAAGCPAGAAPDRPPGSPWLAGHAAGSGCAATTSTPTPAPALTPTPASALAPTPSAGAVGGIPWTQLRYPPDRLAALATGRGVTVAVIDSGVDATYPQLAGRVLAGTDFLDPGGDGRRDCVGHGTAVASIVAAAPRPGSAVRGLAPDVRILPVRVSEQQMVDGRTSGRAGTPDQFAQAIRWSVQHHADVLNLSVVLYRDDPAVRQAVRYALAHDVVVVAAVGNLHEEGDPRSYPAAYPGVIGVGSIGPDGRRSSFSQVGPDVDVAAPGAEVTAAAGPHGAGPHDGTSYAAPFVSATAALVRQYRPTLNAVQVGERILAGTDPAPEAGAGYGAGVLDPERAMTERPGAPAAARPDVPVPAPDHDAARHSARRAAAHRAALLVASVAVLGALLSVAAAAVLPRGRRRRWAPPEGRTDPPDRDR
>NZ_CP022961.1|WP_095567500.1|475301_477557_+|hypothetical-protein
MTDWEPATEAEDALRDALRDEDQERYFLVLSRSELFLPVLAGQEAGWGTWTADGRTHVLAFTSAAAAAACLGEHAGPTRRIRYAELAGRWPSQQWWLAVNPGLPIESYLPAWFVAQLAGGDVRLSGPAGGSTGPADAAAAQARPVEPSPPDPLVRPRSPDPAVQSGLPNPPVQSGPPHPPHPPDPAVQSGPPYPPDPAVQPSPRGRAAENSNGQHWPAPQPARPASSRPPSSRPPQPAGQRDGSFGPPPPPFAPPPFAPPPSAPPPLVPPPFAPPPSAPPPLVPPAASAAEPVPDGAPAGVATAVEQVGFAEPSWPAAPAGHEGGRPLIIDGALVDEFRPETGGRPDAEPAEPGPTDPRPARGAALGDPEPANGAVPTAPTSQPTSQPTSQPAPIPSADDPGRDPAGAAGGDPAADPGGHHAADPGVAEPPDEEFTPANDVEERLYDAAAQGSTDAFLSTLLLARVLLPVDPASTAGAVPGEPGFRWRTEPLGEERFVVVFTSPERLAEHLPPDTPLTTVSFVQLIRRWPDPAWSFAVNPGTPVGAKLPGEQVLALANWAGEAGLEDEPGAAAGPGPSPQEPEPAGPAAPAPPVLMQKAVAPSQLGYYLERGYDRVAGFVQRAAEVSHLRTPAELYAALGLHHPGSPFDRDAGEIYLLRWPAYRPDLYRVPFGGQTDEAMRAIQGWMVERPPFRGNGFAPGDGRNVIAEFKLDSVRLPHGAQLWRVAADGTERLVATLDTDLLGWIPAVPS
>NZ_CP022961.1|WP_095563391.1|477553_477919_+|hypothetical-protein
MIRDGYLARWRDREYDASPDGERVRLYLSEPAEDFTEVEPGRYARVVPAGEVTELVYVRTVCSWHGQPFIVLAAQDGWLRLEYIGGRWPVAQALGLEAFEYGVYQGWARAAEVTGLQEHRV
>NZ_CP022961.1|WP_095563392.1|478053_478992_-|alpha/beta-hydrolase
MSERIVRLDAVDESCVLTDGPWTHRFVGANGSRFHVVEAGTGPMVLFLHGFPEFWWAWHEILPAVADAGFRAVAADLRGYGASDKPPRGYDGYTLAADVAGLIRGLGERSATVVGTGAGGMLGWAAAAFHPTLVRRLVILGAPHPLRLRTAIFADPRGQFAAATPTLRFQLPRYEHVLTRNDAALIGEILARWGGADWVHGPSFAGYVARYREAMRIPQAAFCALEGYRWAFRSALRLHGYRFVKLMQEPIVTPTLQLHGALDGASLPRTAQGSGRYVIAPYEWRLLDRVGHFPHLEVPDLVLGEVLRWAKS
>NZ_CP022961.1|WP_157756566.1|479086_479614_-|hypothetical-protein
MSFNRRIISGSVAPLLGLGLAVAGCAGPKGDAVPRSSAVPSSSGTPSSSGGPEGARPSAEPSGPSDPTSPAGPPASTRPPLSNPVPPTMGPAGKPPKDPTDRIPADTIGGWITRGGSGPCYGLVDDDGVEYALHGTGAGTLAVGTRVVATIGPAPADVDCGPGRPVQLRSVRRLT
>NZ_CP022961.1|WP_095563395.1|479712_482115_-|M6-family-metalloprotease-domain-containing-protein
MGLLGLSLTATGVALGPSAMAAPVSKAAAVTPAAADAAPQRDELPNPLEDKRRALRQEGLTSVLNGESKAEKRNGSTVVKVGETAGSGIAGKGARALVGGKTAKKKKDQYVELAREKTDHIFVILAEFGNERHPNYPDQDTDPNTPGPTRFDGPLNNEIPEPNRAVDNTTVWQPDYDADHYRQMYFGTGKGVESLKTYYETQSSGRYSVDGEVTDWVRVQYNEARYGRSNGYPCGSSVCNNVWALVRDAANQWVADQKAQGRTDAEIAEDVKQFDQWDRYDYDGDGDFNEPDGYIDHFQIVHAGGDQADGDPYQGEDAIWSHRWYAYGSDIGRTGPADNPLGGTQIGDTGLWIGDYTMQPENGGLSVFCHEYGHDLGLPDDYDTNGAGDNAVEHWSLMAQSRLNAKDDQALGTRPGDIGAWQKLQLGWLDYEVVVAGQKRTLNLGPQEYNSAKAQAVVVPLPKKSVTTDLGAPFEGSKQYFSGNADDLNNTMTREFDLTGATSASLSMKARYSIEEGYDYMYLETSTDGGQSWTAMDGTVGGEAFDHDASGTPAIDGSSGGAWVDLNVPLDSVAGQNVLFRFHYRTDGGVSEGGMFGDAITVTADGSTVFSDGAESDAGWALKGFSVVGASVTNLYDNYYIAGNRSYVSYDKYLKTGPYYFSYMNSRPDYVDHYPYQQGLLISYWDTSQVDNNVSDHPGEGLNLYIDAHPRPIYNLTGNPWRVRVQIYDAPFSLKKADSFTLHINGQPQYIRGQDAQPLFNDTKNYFDPALPNHGVKLPAAGVKIKVLEQNGTSMKIRIS
>NZ_CP022961.1|WP_095563396.1|482450_484556_-|acetate--CoA-ligase
MSETLANLLNETRVFPPPDGLANDANVTAAAYDEAAADRLAFWAKQADRLDWAQRWEQTLDWSNPPFAKWFVGGRLNVAYNCLDRHVAAGNGDRVAIHWEGEPGDTRTITYAQLLKLTCQAANALTDLGVTAGDRVAIYLPMIPEAAVAMLACARIGATHSVVFGGFSADALSSRIADASAKLVITSDGGYRRGKPSDLKSTVDEAVSRSDTVEHVLVVRRTGGEVAWGDKDVWWHEAVETADESHEASAFDAEHPLFILYTSGTTAKPKGILHTTGGYLTQASYTTHAVFDLKPETDVYWCTADIGWVTGHSYIVYGPLSNGATQVMYEGTPDTPDRGRFWEIVDRYRVSILYTAPTLIRTMMKWGEDIPQEHDLSSLRLLGSVGEPINPEAWMWYRQHIGRGNCPVVDTWWQTETGAMMISPLPGVTATKPGSAMSPLPGIAADVVDDQGVPVPNGGGGYLVLREPWPSMLRTIWGDDQRFLETYWSRFGAGADGQHSGAGADGQHSGAGADGQHSGAGADGQHSGAGADGNGGGGEWVYFAGDGAKKDDDGHLWLLGRVDDVMLVSGHNISTTEVESALVSHPSVAEAAVVGATDPTTGQAIVAFTIPRGNIDTSGDAGEALIAELRNHVAKTLGPIAKPRQIMLVPELPKTRSGKIMRRLLRDVAENRSLGDVTTLQDSSVMELISSGMRSGKSDED
>NZ_CP022961.1|WP_095563397.1|484764_485595_+|oxidoreductase
MTTDPLAPLLSLADVAPAVDHARDRVDQALRHRALRRQGGRVAAEVSLRCAVASAAIEGHGYDLDAVRAGTVTDPVVQGALRVAGELPGLADRWSRAPRQVLARLHVLAARDAVPADELGRPGAAAPGDRPPVSPAGAGPGAVAAPQVSPAGGPAVGAALGVRLDGLAALVAGGTSAPPVLLAAVVHGELLALRPFAGPSGVVARAAARLTLLSTGFDPRGLVAVDLGHRERQPEYVGSAGAFATGTPDGLRSWLRHYVAAVELGADRLTQICDEI

Crispr_ID: NZ_CP022961_6

• CRISPR_ID: NZ_CP022961_6
• CRISPR_location: 960031-960110
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_6

Consensus_repeat	Method
GCCGGCCGTGCGCGTTGCCGGGGC	CRISPRCasFinder

spacers of NZ_CP022961_6

>6.1|960055|32|NZ_CP022961|CRISPRCasFinder
CGGCTGCGTACCGGGGCCGGCTGCGCGGCGGA

CRISPR arrays and Neighbor proteins around NZ_CP022961_6

CRISPR arrays

The CRISPR arrays of NZ_CP022961_6

>merge|NZ_CP022961|6|960031-960110|CRISPRCasFinder
GCCGGCCGTGCGCGTTGCCGGGGCCGGCTGCGTACCGGGGCCGGCTGCGCGGCGGAGCCGGCCGTGCGCGTTGCCGGGGC

>NZ_CP022961|6|6|960031-960110|CRISPRCasFinder
GCCGGCCGTGCGCGTTGCCGGGGC	CGGCTGCGTACCGGGGCCGGCTGCGCGGCGGA
GCCGGCCGTGCGCGTTGCCGGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095563757.1|961645_962125_-|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl|CDD|237976
NZ_CP022961.1|WP_095563754.1|958060_960007_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213221
NZ_CP022961.1|WP_095563755.1|960127_960811_-|DUF4142-domain-containing-protein	unknown	unknown	gnl|CDD|379301
NZ_CP022961.1|WP_095563753.1|956330_958064_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP022961.1|WP_095563751.1|955032_955851_-|type-I-methionyl-aminopeptidase	unknown	unknown	gnl|CDD|238519
NZ_CP022961.1|WP_095563747.1|951684_952398_+|uracil-DNA-glycosylase	unknown	unknown	gnl|CDD|235376
NZ_CP022961.1|WP_095563752.1|955925_956192_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|379188
NZ_CP022961.1|WP_095567561.1|953205_953634_+|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl|CDD|273701
NZ_CP022961.1|WP_095563759.1|964040_965687_+|chaperonin-GroEL	unknown	unknown	gnl|CDD|234573
NZ_CP022961.1|WP_095563761.1|967422_968181_-|hypothetical-protein	unknown	unknown	gnl|CDD|227324
NZ_CP022961.1|WP_095563763.1|970206_970599_-|DUF5319-domain-containing-protein	unknown	unknown	gnl|CDD|379954
NZ_CP022961.1|WP_095567562.1|962136_963399_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|380115
NZ_CP022961.1|WP_095563746.1|951120_951606_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl|CDD|376771
NZ_CP022961.1|WP_095563758.1|963653_963968_+|co-chaperone-GroES	unknown	unknown	gnl|CDD|178988
NZ_CP022961.1|WP_095563762.1|969171_970158_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NZ_CP022961.1|WP_095563748.1|952487_953165_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl|CDD|274750
NZ_CP022961.1|WP_095563750.1|954702_954957_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563760.1|965782_967363_+|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|239028
NZ_CP022961.1|WP_095563756.1|961002_961515_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP022961.1|WP_095563749.1|953626_954706_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl|CDD|236585

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095563757.1|961645_962125_-|Cys-tRNA(Pro)-deacylase	gnl|CDD|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	6.26886e-70
NZ_CP022961.1|WP_095563754.1|958060_960007_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213221	cd03254, ABCC_Glucan_exporter_like, ATP-binding cassette domain of glucan transporter and related proteins, subfamily C. Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.17594e-72
NZ_CP022961.1|WP_095563755.1|960127_960811_-|DUF4142-domain-containing-protein	gnl|CDD|379301	pfam13628, DUF4142, Domain of unknown function (DUF4142). This is a bacterial family of unknown function.	1.53418e-11
NZ_CP022961.1|WP_095563753.1|956330_958064_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.5317e-84
NZ_CP022961.1|WP_095563751.1|955032_955851_-|type-I-methionyl-aminopeptidase	gnl|CDD|238519	cd01086, MetAP1, Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.	2.073e-103
NZ_CP022961.1|WP_095563747.1|951684_952398_+|uracil-DNA-glycosylase	gnl|CDD|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.32106e-110
NZ_CP022961.1|WP_095563752.1|955925_956192_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	2.29683e-05
NZ_CP022961.1|WP_095567561.1|953205_953634_+|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl|CDD|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	5.68055e-30
NZ_CP022961.1|WP_095563759.1|964040_965687_+|chaperonin-GroEL	gnl|CDD|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP022961.1|WP_095563761.1|967422_968181_-|hypothetical-protein	gnl|CDD|227324	COG4991, COG4991, Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown].	1.91859e-05
NZ_CP022961.1|WP_095563763.1|970206_970599_-|DUF5319-domain-containing-protein	gnl|CDD|379954	pfam17252, DUF5319, Family of unknown function (DUF5319). This is a family of unknown function mostly found in Actinobacteria.	2.90977e-55
NZ_CP022961.1|WP_095567562.1|962136_963399_-|methyltransferase-domain-containing-protein	gnl|CDD|380115	pfam18096, Thump_like, THUMP domain-like. This is a domain of unknown function found in bacteria.	3.71355e-18
NZ_CP022961.1|WP_095563746.1|951120_951606_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl|CDD|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	2.49624e-47
NZ_CP022961.1|WP_095563758.1|963653_963968_+|co-chaperone-GroES	gnl|CDD|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	9.80864e-51
NZ_CP022961.1|WP_095563762.1|969171_970158_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.33709e-20
NZ_CP022961.1|WP_095563756.1|961002_961515_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.32778e-16
NZ_CP022961.1|WP_095563760.1|965782_967363_+|molybdopterin-dependent-oxidoreductase	gnl|CDD|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	1.51453e-83
NZ_CP022961.1|WP_095563748.1|952487_953165_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl|CDD|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	1.55103e-50
NZ_CP022961.1|WP_095563749.1|953626_954706_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl|CDD|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	2.91086e-175

Protein sequences

>NZ_CP022961.1|WP_095563754.1|958060_960007_+|ABC-transporter-ATP-binding-protein
MSTALPVADGGQVRRYARTILRRHPRALGITLGLHALAAIAGLAAPRLLGDLVEAVSRGTSTVTVDRVALAITGFVLVQAVLTRFAYLASARLGEGVLADLREEFIDRVLAIPLSTVERAGTGDLLTRTSRDVAALGKTVRFAVPETLIALVSMVFVVGAMVLVSPLLALSCLVAVPPLWVVTRWYLRRAPAGYLRENAAYSQVTDGISETVDGSRSTEALGQQARRRARTDADIRRSYAAERYTLSLRSVAWPVSEASYVLPVVVTLLLGGWFHLRGWVTLGQVTAAALYAQQLIEPLDRLLSWLDELQVGGASLARLLGVARLPGEASGTPAVAGGVPAVAAGGPVAGPRLVVAPRAGGAEPPLHSDGAGPSTLSDGAGPALLSDGAGPALLSDGAGPALLSDGAGPALCAENVRYAYRTGRDVLHGVTLRLRPGERLAMVGPSGAGKSTLGRLLAGIHAPRSGAVTVGGKALHDLPLAELRRQVALVSQEHHVFLGTLRDNLTMVRPEATDRDVRDALAAVDALDWALALPDGLDTGIGTGGHPLPAGQAQQLALARLVLADPHTLVLDEATSLIDPRAARRLERSMAGVLRGRTVVAIAHRLFSAHDADRVAVVEDGRIIELGSHDELVAAGGSYASLWRSWHG
>NZ_CP022961.1|WP_095563753.1|956330_958064_+|ABC-transporter-ATP-binding-protein
MPALPVVDPGVPDRRSPSRLLLWLAARTGAWLTAGIVFGIVWMVSQALMPAAIGRAVDAITGRDEAELLRWSLLLLALGLTQAGSGVLRHRMASANWLAAAYRTVQVTIDQANRLGATLPRRMAAGEVVSIGTADIGQLGGAMDITARGSGAVVAIGTVTAILLAASVRLGLVVLLGVPVLLAIVGLLIRPLHRRQQTYRDQQAALATRAVDIVAGLRVLRGIGGEPVVSERYRRESQVLRADGVRVARVESLLAGAEILLPGAFVALVTWLGARFVLRGEITAGQLVAFYGYAAFLVGPMRTITEVIDKITKGHVAARRVVDLLRLVPEISDPGTPVPSPGPGELVDAASGLVLRTGRCTALVAAAPEDAVRIADRLGRYAPGEVTLRGVPLGDLPLATVRRRIMVADNDAVLFSGPLRAELDPRDDADEGRITAALRVADATDIVEALPEGLAAPVTARGREFSGGQQQRLRLARALVADPEILILVEPTSAVDAHTEARIADRLGPARTGRTTLICTSSPLVLDRVDHVVFVRDGRTVAEGTHRDLLAAVPEYRATVSRAEAEDPRDDRIEVGR
>NZ_CP022961.1|WP_095563752.1|955925_956192_+|helix-turn-helix-transcriptional-regulator
MVRQPLTAEQIAAGRRLGAALRVARADRSLVEVALAAGISPETLRKIEGGRLPAPAFGTVVGLSRALDVPLGELADVWLADLPIRQAS
>NZ_CP022961.1|WP_095563751.1|955032_955851_-|type-I-methionyl-aminopeptidase
MIELKSAEEIDRMAVAGQFVGELLAELSDVAEVGVNLMDLEHHARRRISERGAESCYWDYAPSFGRGPFRNVLCLSVNDAVLHGLPHSYPLRDGDLLSIDMAVGIDGWVADSALSVIVGTPDPADLRLIEATEVALAAGIAAAAPGGRLGDISAAIGEVARSYGYGVNAEFGGHGIGRTMHEAPHVPNTGRARRGIRLDPGLTIAIEPWFCRTTDKIKFDRDGWTIRSADGSRTAHSEHTVAITPSGTRVLTRRPARGTAAAGPASKPGTAS
>NZ_CP022961.1|WP_095563750.1|954702_954957_+|hypothetical-protein
MIVRMWEARAEPKGFAELIAWVCDVAVPEFEHDPRHAGSEVFSSTDDRIVVISRWRGAPPSMPDPPPLLVARPPHEWDFTPVDR
>NZ_CP022961.1|WP_095563749.1|953626_954706_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MADEPLILGIETSCDETGVGIVRGHTLLADAIASSVAEHARFGGVVPEVASRAHLEAIVPTMRRALAEAGVTIADIDAIAVTAGPGLAGALLVGVAAAKGYALAAEKPVYGVNHLAAHVAVDTLEHGPLPEPAIALLVSGGHSSLLLVDDLARGVTPLGATIDDAAGEAFDKVARLLGLPFPGGPPIDREARAGDAAAIAFPRGLTAPKDQAAHRYDFSFSGLKTAVARWVEARQRAGEPVPVADVAASFQEAVCDVLTAKAIDACRANGVQTLVIGGGVAANSRLRAVAEQRAARHGIRVRVPRPKLCTDNGAMVAALGAHLVAADVAPSKLDLPADSALPLTVVSVQADRYGRRTTG
>NZ_CP022961.1|WP_095567561.1|953205_953634_+|ribosomal-protein-S18-alanine-N-acetyltransferase
MRWWHIEAVLPMEDDLFGVERWSAAMFWNELANGHHYVVALPERGEQPVGYAGLALQPPAEAWVQNIAVRRDRQRSGVGRALLAELLRTADDAGVRTVLLEVAVDNAPAQKLYARNGFEPLGIRRGYYQPSNTDALVMERHG
>NZ_CP022961.1|WP_095563748.1|952487_953165_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MLVLVVDSSTPAVTAALAELTGTAVAIRAERRTVDARAHGELLAPGIDAVLAEAGVRPADLAAIVAGTGPGPFTGLRVGLVTAATMGQVLGIPTYGVCSLDALGRAAAGAGPVLVASDARRREVYWAVYDGAGGRLAGPEVGPAEDAVARARDLGVDAAVGEGAHRYAERIDLPLRAEPRFPPALALAELAAPRAAAGAATEPLTPLYLRRPDAVAATARKPVLP
>NZ_CP022961.1|WP_095563747.1|951684_952398_+|uracil-DNA-glycosylase
MTDAAPASVPTLDLPALLPPAWREALAPHLEPADTAALGAFVAREYASRQVYPPVEDLFAAYRLCQPQDCRVLLLGQDPYHRAGQAHGLSFSVRPGVRVPPSLRNVFRELAADLEVDPPVGGDLTGWAEQGVLLLNSVLTVREGSPNSHAGHGWEAFTDATIRALDARAERIVFLLWGGYARRKRGLIVNPAHVVLEAGHPSPLNPRGFRGCRAFSATNKALADAGRPTIVWEHPAG
>NZ_CP022961.1|WP_095563746.1|951120_951606_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MTRTVRSLPTVEDTHAFGRTLAGRLRAGDLLVLTGPLGAGKTALVQGIGAGLGVAGEVTSPTFVIARVHRADPDRGGRVPLVHADAYRLGDATDPRAEIDDLDLDASMDEAVTVVEWGEGLVEQLGDAHLRIRIDRRDDDTRLVELEPVGGDWADRLAGWS
>NZ_CP022961.1|WP_095563755.1|960127_960811_-|DUF4142-domain-containing-protein
MAAILAGLIAGMVLLPSAASAEPAPAQLNAADTMLLNGVRQAGLWEIPAGQMAAEKGKRQRVREVGAEIAKQHVELDQMVVDTANKLGAQIPADPRADQKGWLAEMQVASGDRFDQTFVSRLRAAHGKIFPVIGAVRAGTRNDDVRKLADAANIFVMNHMKLLESTGLVRYSELPPAAVPALQDEGMFARARANAGSGAPVSGNLIWIVLIAALAAGGVATFRLVRR
>NZ_CP022961.1|WP_095563756.1|961002_961515_-|MarR-family-transcriptional-regulator
MTREATGGELDRLTAGLSALSRVIVAITAAAVATLDVELTLTQHRMIVVLATTGPRRTVDLAADLGVHPSTASRTGDRLVRRGLLARDHLPSDRRVSWLRLTDPGRELVADIVRRRTSDLRRLLAAVPTGADRSPGDLVDALVTAAGEPTEPVWWRHWATASRPPGATLP
>NZ_CP022961.1|WP_095563757.1|961645_962125_-|Cys-tRNA(Pro)-deacylase
MAGQGTPATALLARQRVQHSVHPYDVPVDTAHYGAEVAAALGVPAGEVFKSLVVEVDGRLVVAVVPVTGELDLKALAAAAGGKRAALADRALAERTTGYVRGGISPLGQRRRLPTVVDSSVETLAAMYVSAGRRGLQLRIAPADLIRLTGATTAAIATG
>NZ_CP022961.1|WP_095567562.1|962136_963399_-|methyltransferase-domain-containing-protein
MDTDGLAVLRTAEGQAALATAADLAGGDPLAAAAALRAGGVPADLAAAALTQAELRRHAVGKFGPDAATMYFSRAGLEQATRAAVADRRAARLHEAGVRTLADLGCGLGADALAAARHGIRVYGVEADPTTASLARANAAALGLADLFTVECGDATGYDVTGVDAVFCDPARRRGGRRIFDPDAYSPPWSFVTALAERVPRTVVKVAPGIDHAAIPPDAEAEWVSAAGDLVEATIWCGPLAEVPRRASLLGRQSRTLRAGTDAGEHQLTGAGTRQAAVGPVRRFLYDPDGAVLRAHLVAEFADTLDGTLADPDIAYVYADRAVATPFARCLEITDVLPFSLKRLRALLRERGVGRVEILKRGSALVPERLRRDLRPAGPAAASLVLTRVAGAPTVLIGHPVGDPIGSSAGGPSRQPAGGG
>NZ_CP022961.1|WP_095563758.1|963653_963968_+|co-chaperone-GroES
MPVTTATKVAIKPLEDRIVVQANEAETTTASGIVIPDTAKEKPQEGTVLAVGPGRVDDSGNRVPIDVKVGDTVLYSKYGGTEVKYAGEEYLVLSARDVLAIIEK
>NZ_CP022961.1|WP_095563759.1|964040_965687_+|chaperonin-GroEL
MAKILSFSDDARHLLEHGVNALADTVKVTLGPRGRNVVLDKKFGAPTITNDGVTIAKEIELTNPYENLGAQLVKEVATKTNDVAGDGTTTATVLAQAMVREGLRNVAAGANPTGLKRGIDAAANKVSDALLGKAVEVGGKESVAHVATISAQDATIGEMIAEAMEKVGRDGVITVEEGSTLATELEVTEGLQFDKGFISPNFVTDSESQEAVLDDPYILITTQKISAIEELLPLLEKILSDSKPLLIVAEDVEGQALATLVVNSIRKTLKVCAVKAPGFGDRRKAMLQDMAVLTGAELVAPELGYKLDQVGLEVLGGARRVVVDKENTTVIDGKGRDTEVADRIGQIRKEIEASDSDWDREKLSERLAKLSGGIAVIKAGAATEVEMKERKHRIEDAISATKAAVEEGTVPGGGAALVQIAALLEDGLGLTGDEKVGVSIVRKSLLEPLRWIAQNAGQDGYVVVQKVIGADWGTGLNAATGEYVDLAAAGILDPVKVTRNAVLNAASIAGLLLTTESLVVEKPAEPEPAAAGGHGHSHGHGHQHGPGF
>NZ_CP022961.1|WP_095563760.1|965782_967363_+|molybdopterin-dependent-oxidoreductase
MFGGWGKTGPVRTRSRPFAALAGLVAAAVTIGVAELVAVATGPRSAPLIAVGGAVVDAVPAPVKQFAIDVFGVHDKLALLVGTAVLLGGFAALVGLLARRRFWLGPLGIGVFALIGVAAAVTRPGAGPAAALPTLVGAGVAVGVFWLLLAGPLEIPAPPLDPDAEHDVAEFESGRRRFLTGAGAALGAAALTGFAGRWLATRRSVIAAREAIRLPVPASPAAPLPAGADLSLGGLAPFTTPNFAFYRIDTALTVPQVDPEQWRLRITGRVRNPITLTYQDLLARPMLERDITLTCVSNEVGGDLIGNARWLGVPIADLLAEAEPLDGADQVVGRSVDGWTCGTPTAALRDGRDALLAVGMNGEPLPVEHGFPVRMVVPGLYGYVSACKWVTELALTSFADFDAYWVPRGWSAQGPIKTQSRIDTPRQGKRLAAGPVTVAGVAWAQHRGIRAVEVRVDEGPWQPATLAPVPSADTWVQWVWQWPATPGEHTLQVRATDAAGVAQTGEVAPVVPDGATGWHEVQVSVH
>NZ_CP022961.1|WP_095563761.1|967422_968181_-|hypothetical-protein
MWEYVNVPPARYLRGIAVAAVLATGLVATVPGTALAYASSASGTISTAGAALNVRSGPSTSRTAWRTVANGASVTLLCQTTGESVSGTYGTTKLWDMLGNGGMVSDAYVYTGSDGQVVNSCSYVGAEPSSKTNPRATEGAISWAFARYHSTAYENLCLAFVAQAYGWGGSGWNTAEIGGDWESSHGYLKTSGIPPRGALVWYHNSSGTGHVAISLGEGKVVGTSVSGSVGVAGYLDHGSYRGWSVAYLPAAW
>NZ_CP022961.1|WP_095563762.1|969171_970158_+|helix-turn-helix-transcriptional-regulator
MRTVLVCVRTPLAAQNVAAAAARLGLTAAVRTAVSDPEVMLRLAERPADVILADTALTRPDSAGFTRRVLARSPGAAVVLLGTEEPGAAAAAVAAGARGLVSAGDHDLVGAVARAMLLLSSPHRAIRPGELNGAAREGRGGVPEASRALRGGQHPDGRAVPGDGPLPGGGPLPGRGAGSAGSGAGGADPAHRRPAAPEAAPPGDPSGPAVVPVQRAEDGAEPRGADGEPAPNDPRANIAPEARYGGTRRGEANTSHSRGTPARRVTLTEREMQVLLGMADGKSNAEIGRELFVSEDTVKTHARRLFRKLGARDRAHAVAAGFRAGLVA
>NZ_CP022961.1|WP_095563763.1|970206_970599_-|DUF5319-domain-containing-protein
MHDEPIDPFTGDPADPSASLEDPVEDDALDPLSEVERQDVLEDLADLEIYQALLGPTGIRGLVIECEDCREPHYFDWALLRGNLRHLLDSGRPRVHEPAYNPDPDHYVSWEYARGYADGVHDTLSDSDEE

Crispr_ID: NZ_CP022961_7

• CRISPR_ID: NZ_CP022961_7
• CRISPR_location: 1074128-1075681
• CRISPR_type: Orphan
• Repeat_type: I-E
• Spacer_info: 25 spacers

Consensus repeat of NZ_CP022961_7

Consensus_repeat	Method
GGATCACCCCCGCATGCGCGGGGAGCAC	CRISPRCasFinder
GGATCACCCCCGCATGCGCGGGGAGCAC	CRT
GTGCTCCCCGCGCATGCGGGGGTGATCC	PILER-CR

spacers of NZ_CP022961_7

>7.1|1074156|33|NZ_CP022961|CRISPRCasFinder,CRT
CTGTGCCCATGCCCATGGCGTCGTCCACGCACA
>7.2|1074217|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CACCGTCTCACCAGCCTGTAGTACGGCGAGCAC
>7.3|1074278|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
AGGACGGTGACGATGGACAACCCGATCGCCGTG
>7.4|1074339|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CATGACTCTCTGTTCACTCTTCCAGCTCCTCAA
>7.5|1074400|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CGAGCCCATACGCCTCCCCAGGCGGCCATATGC
>7.6|1074461|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GATGTCGCCGGCCTCGGCGTTGTAGGTCGCGAC
>7.7|1074522|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GTGCTGGATATGCCGCGTCCGGCCGTTCGCGCA
>7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CCGCTGTGACCAAGGACGGCAAGACGGTCTTGG
>7.9|1074644|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CAACGACGGGGGTTCGATGACCCTCACGATCAA
>7.10|1074705|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GCGGTGGCCGGCCGCCACCACACACGCGCCGAG
>7.11|1074766|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
ACGGCGGTGGGGTTTGTGAACGTGGCGGACAGG
>7.12|1074827|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
TCCGTGATGGTCCGCTCGGGGATGCCGCGCGGG
>7.13|1074888|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
TCCGACGATCTGGCGATCACACGGGGCGCCAAG
>7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
AGACGTCGTCGGCGGTCACCGTCCGGCCTCGCT
>7.15|1075010|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CTGTGTCGTGTCGTCCACCCGCATCGCCTCCCG
>7.16|1075071|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CCAGTCCCCGTGTGGCCGGTTCAGCACGGCGCC
>7.17|1075132|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GTTCGACGCGCAGCGTGGAGGGAATCTCCGCCC
>7.18|1075193|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GTGCCCGGATCCCCCTACAACGACGACATCCCG
>7.19|1075254|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GCATGGCGCTCGGTCCGGTGAGTCAGCGCCTGC
>7.20|1075315|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CGCCGCGTGCAGCTCCCCCGTGGTCGTCCCGAG
>7.21|1075376|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
ATCGTTTCGACCCTGGCAAGGTTGAGAATGTCA
>7.22|1075437|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GGCATGTACGCCTGTACGAAATCGGTGCGGAAC
>7.23|1075498|34|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GTCCGCCTTCCGCTGCGCAGCAGTGGTTTTGCCC
>7.24|1075560|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
CTGGGCATCTCGAATGGGCAGGTGTCCACCCTG
>7.25|1075621|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR
GCCGGCGGGTAGGCACCCGGCACGGGCGTGTCC

CRISPR arrays and Neighbor proteins around NZ_CP022961_7

CRISPR arrays

The CRISPR arrays of NZ_CP022961_7

>merge|NZ_CP022961|7|1074128-1075681|CRISPRCasFinder,CRT,PILER-CR
GGATCACCTCCGCATGCGCGGCGAGCACCTGTGCCCATGCCCATGGCGTCGTCCACGCACAGGATCACCCCCGCATGCGCGGGGAGCACCACCGTCTCACCAGCCTGTAGTACGGCGAGCACGGATCACCCCCGCATGCGCGGGGAGCACAGGACGGTGACGATGGACAACCCGATCGCCGTGGGATCACCCCCGCATGCGCGGGGAGCACCATGACTCTCTGTTCACTCTTCCAGCTCCTCAAGGATCACCCCCGCATGCGCGGGGAGCACCGAGCCCATACGCCTCCCCAGGCGGCCATATGCGGATCACCCCCGCATGCGCGGGGAGCACGATGTCGCCGGCCTCGGCGTTGTAGGTCGCGACGGATCACCCCCGCATGCGCGGGGAGCATGTGCTGGATATGCCGCGTCCGGCCGTTCGCGCAGGATCACCCCCGCATGCGCGGGGAGCACCCGCTGTGACCAAGGACGGCAAGACGGTCTTGGGGATCACCCCCGCATGCGCGGGGAGCACCAACGACGGGGGTTCGATGACCCTCACGATCAAGGATCACCCCCGCATGCGCGGGGAGCACGCGGTGGCCGGCCGCCACCACACACGCGCCGAGGGATCACCCCCGCATGCGCGGGGAGCACACGGCGGTGGGGTTTGTGAACGTGGCGGACAGGGGATCACCCCCGCATGCGCGGGGAGCACTCCGTGATGGTCCGCTCGGGGATGCCGCGCGGGGGATCACCCCCGCATGCGCGGGGAGCACTCCGACGATCTGGCGATCACACGGGGCGCCAAGGGATCACCCCCGCATGCGCGGGGAGCACAGACGTCGTCGGCGGTCACCGTCCGGCCTCGCTGGATCACCCCCGCATGCGCGGGGAGCACCTGTGTCGTGTCGTCCACCCGCATCGCCTCCCGGGATCACCCCCGCATGCGCGGGGAGCACCCAGTCCCCGTGTGGCCGGTTCAGCACGGCGCCGGATCACCCCCGCATGCGCGGGGAGCACGTTCGACGCGCAGCGTGGAGGGAATCTCCGCCCGGATCACCCCCGCATGCGCGGGGAGCACGTGCCCGGATCCCCCTACAACGACGACATCCCGGGATCACCCCCGCATGCGCGGGGAGCACGCATGGCGCTCGGTCCGGTGAGTCAGCGCCTGCGGATCACCCCCGCATGCGCGGGGAGCACCGCCGCGTGCAGCTCCCCCGTGGTCGTCCCGAGGGATCACCCCCGCATGCGCGGGGAGCACATCGTTTCGACCCTGGCAAGGTTGAGAATGTCAGGATCACCCCCGCATGCGCGGGGAGCACGGCATGTACGCCTGTACGAAATCGGTGCGGAACGGATCACCCCCGCATGCGCGGGGAGCACGTCCGCCTTCCGCTGCGCAGCAGTGGTTTTGCCCGGATCACCCCCGCATGCGCGGGGAGCACCTGGGCATCTCGAATGGGCAGGTGTCCACCCTGGGATCACCCCCGCATGTGCGGGGAGCGCGCCGGCGGGTAGGCACCCGGCACGGGCGTGTCCGGATCACCCCCGCATGCGCGGGGAGCAC

>NZ_CP022961|7|7|1074128-1075681|CRISPRCasFinder
GGATCACCTCCGCATGCGCGGCGAGCAC	CTGTGCCCATGCCCATGGCGTCGTCCACGCACA
GGATCACCCCCGCATGCGCGGGGAGCAC	CACCGTCTCACCAGCCTGTAGTACGGCGAGCAC
GGATCACCCCCGCATGCGCGGGGAGCAC	AGGACGGTGACGATGGACAACCCGATCGCCGTG
GGATCACCCCCGCATGCGCGGGGAGCAC	CATGACTCTCTGTTCACTCTTCCAGCTCCTCAA
GGATCACCCCCGCATGCGCGGGGAGCAC	CGAGCCCATACGCCTCCCCAGGCGGCCATATGC
GGATCACCCCCGCATGCGCGGGGAGCAC	GATGTCGCCGGCCTCGGCGTTGTAGGTCGCGAC
GGATCACCCCCGCATGCGCGGGGAGCAT	GTGCTGGATATGCCGCGTCCGGCCGTTCGCGCA
GGATCACCCCCGCATGCGCGGGGAGCAC	CCGCTGTGACCAAGGACGGCAAGACGGTCTTGG
GGATCACCCCCGCATGCGCGGGGAGCAC	CAACGACGGGGGTTCGATGACCCTCACGATCAA
GGATCACCCCCGCATGCGCGGGGAGCAC	GCGGTGGCCGGCCGCCACCACACACGCGCCGAG
GGATCACCCCCGCATGCGCGGGGAGCAC	ACGGCGGTGGGGTTTGTGAACGTGGCGGACAGG
GGATCACCCCCGCATGCGCGGGGAGCAC	TCCGTGATGGTCCGCTCGGGGATGCCGCGCGGG
GGATCACCCCCGCATGCGCGGGGAGCAC	TCCGACGATCTGGCGATCACACGGGGCGCCAAG
GGATCACCCCCGCATGCGCGGGGAGCAC	AGACGTCGTCGGCGGTCACCGTCCGGCCTCGCT
GGATCACCCCCGCATGCGCGGGGAGCAC	CTGTGTCGTGTCGTCCACCCGCATCGCCTCCCG
GGATCACCCCCGCATGCGCGGGGAGCAC	CCAGTCCCCGTGTGGCCGGTTCAGCACGGCGCC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTTCGACGCGCAGCGTGGAGGGAATCTCCGCCC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTGCCCGGATCCCCCTACAACGACGACATCCCG
GGATCACCCCCGCATGCGCGGGGAGCAC	GCATGGCGCTCGGTCCGGTGAGTCAGCGCCTGC
GGATCACCCCCGCATGCGCGGGGAGCAC	CGCCGCGTGCAGCTCCCCCGTGGTCGTCCCGAG
GGATCACCCCCGCATGCGCGGGGAGCAC	ATCGTTTCGACCCTGGCAAGGTTGAGAATGTCA
GGATCACCCCCGCATGCGCGGGGAGCAC	GGCATGTACGCCTGTACGAAATCGGTGCGGAAC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTCCGCCTTCCGCTGCGCAGCAGTGGTTTTGCCC
GGATCACCCCCGCATGCGCGGGGAGCAC	CTGGGCATCTCGAATGGGCAGGTGTCCACCCTG
GGATCACCCCCGCATGTGCGGGGAGCGC	GCCGGCGGGTAGGCACCCGGCACGGGCGTGTCC
GGATCACCCCCGCATGCGCGGGGAGCAC

>NZ_CP022961|7|2|1074128-1075681|CRT
GGATCACCTCCGCATGCGCGGCGAGCAC	CTGTGCCCATGCCCATGGCGTCGTCCACGCACA
GGATCACCCCCGCATGCGCGGGGAGCAC	CACCGTCTCACCAGCCTGTAGTACGGCGAGCAC
GGATCACCCCCGCATGCGCGGGGAGCAC	AGGACGGTGACGATGGACAACCCGATCGCCGTG
GGATCACCCCCGCATGCGCGGGGAGCAC	CATGACTCTCTGTTCACTCTTCCAGCTCCTCAA
GGATCACCCCCGCATGCGCGGGGAGCAC	CGAGCCCATACGCCTCCCCAGGCGGCCATATGC
GGATCACCCCCGCATGCGCGGGGAGCAC	GATGTCGCCGGCCTCGGCGTTGTAGGTCGCGAC
GGATCACCCCCGCATGCGCGGGGAGCAT	GTGCTGGATATGCCGCGTCCGGCCGTTCGCGCA
GGATCACCCCCGCATGCGCGGGGAGCAC	CCGCTGTGACCAAGGACGGCAAGACGGTCTTGG
GGATCACCCCCGCATGCGCGGGGAGCAC	CAACGACGGGGGTTCGATGACCCTCACGATCAA
GGATCACCCCCGCATGCGCGGGGAGCAC	GCGGTGGCCGGCCGCCACCACACACGCGCCGAG
GGATCACCCCCGCATGCGCGGGGAGCAC	ACGGCGGTGGGGTTTGTGAACGTGGCGGACAGG
GGATCACCCCCGCATGCGCGGGGAGCAC	TCCGTGATGGTCCGCTCGGGGATGCCGCGCGGG
GGATCACCCCCGCATGCGCGGGGAGCAC	TCCGACGATCTGGCGATCACACGGGGCGCCAAG
GGATCACCCCCGCATGCGCGGGGAGCAC	AGACGTCGTCGGCGGTCACCGTCCGGCCTCGCT
GGATCACCCCCGCATGCGCGGGGAGCAC	CTGTGTCGTGTCGTCCACCCGCATCGCCTCCCG
GGATCACCCCCGCATGCGCGGGGAGCAC	CCAGTCCCCGTGTGGCCGGTTCAGCACGGCGCC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTTCGACGCGCAGCGTGGAGGGAATCTCCGCCC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTGCCCGGATCCCCCTACAACGACGACATCCCG
GGATCACCCCCGCATGCGCGGGGAGCAC	GCATGGCGCTCGGTCCGGTGAGTCAGCGCCTGC
GGATCACCCCCGCATGCGCGGGGAGCAC	CGCCGCGTGCAGCTCCCCCGTGGTCGTCCCGAG
GGATCACCCCCGCATGCGCGGGGAGCAC	ATCGTTTCGACCCTGGCAAGGTTGAGAATGTCA
GGATCACCCCCGCATGCGCGGGGAGCAC	GGCATGTACGCCTGTACGAAATCGGTGCGGAAC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTCCGCCTTCCGCTGCGCAGCAGTGGTTTTGCCC
GGATCACCCCCGCATGCGCGGGGAGCAC	CTGGGCATCTCGAATGGGCAGGTGTCCACCCTG
GGATCACCCCCGCATGTGCGGGGAGCGC	GCCGGCGGGTAGGCACCCGGCACGGGCGTGTCC
GGATCACCCCCGCATGCGCGGGGAGCAC

>NZ_CP022961|7|2|1074189-1075681|PILER-CR
GGATCACCCCCGCATGCGCGGGGAGCAC	CACCGTCTCACCAGCCTGTAGTACGGCGAGCAC
GGATCACCCCCGCATGCGCGGGGAGCAC	AGGACGGTGACGATGGACAACCCGATCGCCGTG
GGATCACCCCCGCATGCGCGGGGAGCAC	CATGACTCTCTGTTCACTCTTCCAGCTCCTCAA
GGATCACCCCCGCATGCGCGGGGAGCAC	CGAGCCCATACGCCTCCCCAGGCGGCCATATGC
GGATCACCCCCGCATGCGCGGGGAGCAC	GATGTCGCCGGCCTCGGCGTTGTAGGTCGCGAC
GGATCACCCCCGCATGCGCGGGGAGCAT	GTGCTGGATATGCCGCGTCCGGCCGTTCGCGCA
GGATCACCCCCGCATGCGCGGGGAGCAC	CCGCTGTGACCAAGGACGGCAAGACGGTCTTGG
GGATCACCCCCGCATGCGCGGGGAGCAC	CAACGACGGGGGTTCGATGACCCTCACGATCAA
GGATCACCCCCGCATGCGCGGGGAGCAC	GCGGTGGCCGGCCGCCACCACACACGCGCCGAG
GGATCACCCCCGCATGCGCGGGGAGCAC	ACGGCGGTGGGGTTTGTGAACGTGGCGGACAGG
GGATCACCCCCGCATGCGCGGGGAGCAC	TCCGTGATGGTCCGCTCGGGGATGCCGCGCGGG
GGATCACCCCCGCATGCGCGGGGAGCAC	TCCGACGATCTGGCGATCACACGGGGCGCCAAG
GGATCACCCCCGCATGCGCGGGGAGCAC	AGACGTCGTCGGCGGTCACCGTCCGGCCTCGCT
GGATCACCCCCGCATGCGCGGGGAGCAC	CTGTGTCGTGTCGTCCACCCGCATCGCCTCCCG
GGATCACCCCCGCATGCGCGGGGAGCAC	CCAGTCCCCGTGTGGCCGGTTCAGCACGGCGCC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTTCGACGCGCAGCGTGGAGGGAATCTCCGCCC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTGCCCGGATCCCCCTACAACGACGACATCCCG
GGATCACCCCCGCATGCGCGGGGAGCAC	GCATGGCGCTCGGTCCGGTGAGTCAGCGCCTGC
GGATCACCCCCGCATGCGCGGGGAGCAC	CGCCGCGTGCAGCTCCCCCGTGGTCGTCCCGAG
GGATCACCCCCGCATGCGCGGGGAGCAC	ATCGTTTCGACCCTGGCAAGGTTGAGAATGTCA
GGATCACCCCCGCATGCGCGGGGAGCAC	GGCATGTACGCCTGTACGAAATCGGTGCGGAAC
GGATCACCCCCGCATGCGCGGGGAGCAC	GTCCGCCTTCCGCTGCGCAGCAGTGGTTTTGCCC
GGATCACCCCCGCATGCGCGGGGAGCAC	CTGGGCATCTCGAATGGGCAGGTGTCCACCCTG
GGATCACCCCCGCATGTGCGGGGAGCGC	GCCGGCGGGTAGGCACCCGGCACGGGCGTGTCC
GGATCACCCCCGCATGCGCGGGGAGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095563830.1|1068062_1068878_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238874
NZ_CP022961.1|WP_095563840.1|1080273_1080684_-|HIT-family-protein	unknown	unknown	gnl|CDD|223611
NZ_CP022961.1|WP_095563837.1|1077274_1077469_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP022961.1|WP_095567574.1|1066344_1066665_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563841.1|1080763_1081906_+|cystathionine-gamma-synthase	unknown	unknown	gnl|CDD|236104
NZ_CP022961.1|WP_095563829.1|1066744_1068007_-|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|181146
NZ_CP022961.1|WP_095563835.1|1075861_1076047_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563827.1|1063331_1065074_-|hypothetical-protein	unknown	unknown	gnl|CDD|287142
NZ_CP022961.1|WP_157756602.1|1076496_1077288_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP022961.1|WP_095563833.1|1071964_1072480_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP022961.1|WP_095563839.1|1079456_1080248_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197775
NZ_CP022961.1|WP_095567575.1|1070100_1070457_+|DUF1232-domain-containing-protein	unknown	unknown	gnl|CDD|377712
NZ_CP022961.1|WP_095567576.1|1077746_1078340_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095563843.1|1083541_1084762_+|threonine-ammonia-lyase	unknown	unknown	gnl|CDD|236182
NZ_CP022961.1|WP_095563838.1|1078490_1079150_-|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl|CDD|234604
NZ_CP022961.1|WP_095563832.1|1070583_1071954_+|cystathionine-beta-synthase	unknown	unknown	gnl|CDD|273464
NZ_CP022961.1|WP_095563834.1|1072476_1073403_-|ribonuclease-Z	unknown	unknown	gnl|CDD|234602
NZ_CP022961.1|WP_095563828.1|1065442_1066294_+|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl|CDD|378959
NZ_CP022961.1|WP_095563842.1|1082058_1083444_+|amidase	unknown	unknown	gnl|CDD|223232
NZ_CP022961.1|WP_095563831.1|1068874_1069918_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238874

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095563839.1|1079456_1080248_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.000260046
NZ_CP022961.1|WP_095563833.1|1071964_1072480_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	8.47417e-12
NZ_CP022961.1|WP_095563843.1|1083541_1084762_+|threonine-ammonia-lyase	gnl|CDD|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NZ_CP022961.1|WP_095563841.1|1080763_1081906_+|cystathionine-gamma-synthase	gnl|CDD|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0
NZ_CP022961.1|WP_095563829.1|1066744_1068007_-|acetyl-CoA-C-acetyltransferase	gnl|CDD|181146	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase.	0
NZ_CP022961.1|WP_095563830.1|1068062_1068878_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238874	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl carrier protein FeeL. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	3.05807e-41
NZ_CP022961.1|WP_095563827.1|1063331_1065074_-|hypothetical-protein	gnl|CDD|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	0.000436794
NZ_CP022961.1|WP_157756602.1|1076496_1077288_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.39199e-11
NZ_CP022961.1|WP_095563840.1|1080273_1080684_-|HIT-family-protein	gnl|CDD|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	5.6697e-37
NZ_CP022961.1|WP_095563837.1|1077274_1077469_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.90353e-18
NZ_CP022961.1|WP_095567575.1|1070100_1070457_+|DUF1232-domain-containing-protein	gnl|CDD|377712	pfam06803, DUF1232, Protein of unknown function (DUF1232). This family represents a conserved region of approximately 60 residues within a number of hypothetical bacterial and archaeal proteins of unknown function.	1.51224e-09
NZ_CP022961.1|WP_095563838.1|1078490_1079150_-|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl|CDD|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	2.90573e-140
NZ_CP022961.1|WP_095563832.1|1070583_1071954_+|cystathionine-beta-synthase	gnl|CDD|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
NZ_CP022961.1|WP_095563834.1|1072476_1073403_-|ribonuclease-Z	gnl|CDD|234602	PRK00055, PRK00055, ribonuclease Z; Reviewed.	1.65745e-117
NZ_CP022961.1|WP_095563828.1|1065442_1066294_+|Bax-inhibitor-1/YccA-family-protein	gnl|CDD|378959	pfam12811, BaxI_1, Bax inhibitor 1 like. The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.	1.35789e-87
NZ_CP022961.1|WP_095563842.1|1082058_1083444_+|amidase	gnl|CDD|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	2.97934e-100
NZ_CP022961.1|WP_095563831.1|1068874_1069918_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238874	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl carrier protein FeeL. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	4.74598e-49

Protein sequences

>NZ_CP022961.1|WP_095563834.1|1072476_1073403_-|ribonuclease-Z
MSRELVVLGTASQVPTRHRNHNGYLLRWDGEGILFDPGEGTQRQMLLAGVSATDVTRICVTHFHGDHCLGLPGVIQRLSLDRVPHPVAAHFPASGADYFAALRHASSFYETADLRPEPVDGDVQVIGTPVGRLEARRLRHPVEAYGYRLVEPDTRRLLPDRLAAYGLAGPAVGELKAAGHLDLGGRRVTLAEVSVSRPGQVFAFVMDTGLCDNVYALAEGADLLVIESTFRTADAKLANDYGHLTAAQAARVAAESGVRRLVLTHFSQRYPDVRGFLDEARAEFPGDVSVAEDLSRFPLPSRRVRSAG
>NZ_CP022961.1|WP_095563833.1|1071964_1072480_-|GNAT-family-N-acetyltransferase
MIITLRPARRTDLMTVGALHHRSRVAAYSGFLAADDLARPTPRALGRYWEQRWLYERADHRLTVVEHGGRVIGFSYVGPDEPEEDPKGGLLNAIHLDPRWLGRGVGRQLMIDALATLVDLGYARARLWVLRDNAVARRFYERGGWSCDGVERTDMIGTAATPQLRYSRELV
>NZ_CP022961.1|WP_095563832.1|1070583_1071954_+|cystathionine-beta-synthase
MRYYDNVVEMIGNTPLVRLRNVTEGIQATVLAKVEYLNPGGSVKDRIALRMVEDAEAAGILRPGGTIVEPTSGNTGVGLALVAQLRGYRCVFVCPDKVSQDKQDVLRAYGAEVVVCPTAVAPEDPRSYYNVSDRLAREIPGAWKPDQYANPANPRSHYETTGPEVWDQTAGRITHFVAGVGTGGTVTGIGRYLKEVSEDAVRVVGADPEGSVYSGGTGRPYLVEGVGEDFWPETYDRKICDEIVEVSDKDSFDMTRRLAREEGLLVGGSCGMATVAALEVARRAGPDDVVVVLLPDSGKGYLSKIFNDDWMARYGFLATGGSEATVAEALAKKPGGLPELVHVHPTETVRDAIDYMREYGVSQLPVLKAEPPVVTGEVAGSIAERDLLDALFTGQAHLHDTIERHMGDPLPMIGGGQPVSEAVDLLEKSDAALVLVDGKPKGVLTRQDLLAHLGAR
>NZ_CP022961.1|WP_095567575.1|1070100_1070457_+|DUF1232-domain-containing-protein
MAKTLKRAAAFTALARALTAGARGGPSLGTRLAALPRMVRATSRGEYDGGLRIAMIAAATAYVVSPIDLVPEAFLMVLGLVDDAVMVTWLAGAVLSETERFLAWEAHRAAVIPGHAVH
>NZ_CP022961.1|WP_095563831.1|1068874_1069918_-|SGNH/GDSL-hydrolase-family-protein
MGQAAAVSGGVAPWALVRRAAKLVVFGAGATAVTVLTASGVLIGQARQARRVIPQAQEPPPRGDGVYGARFPGPPLTLVVLGDSSAAGYGVHRPRETPGALLATGISRRLHRPVRLHRFAVVGALSAGLVPQVDAALEHRPDLAVILVGGNDVTNRTPLPVAVGHLVTAVRTLRDAGAEVVVGTCPDLGAIQPIKPPLRWLARRWSRQLAAAQTVAVVEAGGWTVSLGDLLGPRFAAEPTRMFAWDHFHPSAEGYAIAAAALLPTALSALAGAGGVPAGPQDRGGVRSLPAAAQVAARHAGTEVSAARLGGRDRGPAGRWARLRRRRPSFWRARGAAVASPVEEGVT
>NZ_CP022961.1|WP_095563830.1|1068062_1068878_-|SGNH/GDSL-hydrolase-family-protein
MTGSALGTIAARLGRATIMTLLAGAVGGTAVLAGEAVLAGTRRYAQPDPRLALRCSVGPTGAPPLRLVLLGDSAALGVGVDRVEDTVGGQLARLLAEGSGRAGAGRRLVQLSSVGVVGSRSTDLATQVARALLGPKPDVAVILVGAADAAGLRRPVESAGYLHAAVRRLRIARVEVVVGTCPDLGAVRAIAPPLRQLAGWFGRRTAAAQADAVRAGGGTVVDLAAVAGPVFRADAGTLCHDGYHPSADGYRVWAHALLPAVAEAAAVASRS
>NZ_CP022961.1|WP_095563829.1|1066744_1068007_-|acetyl-CoA-C-acetyltransferase
MPTDPSRTAVIVATARSPIGRAHKGSLRELRPDDLAASVVRAALDKVPQLDATTIDDLYLGCGLPGGEQGFNMARVVATLLGLDGLPGATLTRYCASSLQTTRMAFHAIAAGEGDVFVSAGVEAVSRYARGNSDGLPPEAQALVGGGWENPRFASARERSAARAAGGTATWTDPRADGDLPDVYLAMGQTAENLAQVYDVSRAEMDEFGVRSQNLAEKAIADGFWAREITPVSTPSGAVVSTDDGPRAGVTLEGVAGLKPVFRPDGRITAGNCCPLNDGAAAVVVMSEQRARDLGITPLARIVSTGVTALSPEIMGLGPVEASRQALARAGMSIDDVDLVEINEAFAAQVIPSYRQLGIPLEKLNVMGGAIAVGHPFGMTGARITGTLLNALDWHDRTVGLETMCVGGGQGMAMVLERLS
>NZ_CP022961.1|WP_095567574.1|1066344_1066665_+|hypothetical-protein
MAEAELSRAVDVLVRQVGHWEAPRWAAKAERGNAARADLMHRLVQEIANRAADAAGEPRRTVPRLDNDLALPDQLRVVAADLAAARPPEAVLDAAAAQVRATRLAL
>NZ_CP022961.1|WP_095563828.1|1065442_1066294_+|Bax-inhibitor-1/YccA-family-protein
MKTTNPVLARFGQNAVQERSTGYAPGAGYQQPAYGQGYPGAGHPETAGYPGPAYPASPVGARTMTIDDVVVKTVTLLALLAASAAAAWVLVPDALLGAAWIGAAIIGLVLGLIVSFSRVANPALVVAYAVVEGVFVGMVSKFFTSVLGYQGIVLQAVVATFAVFFAMAMLYKARVVRATPRFTRIVIAAMGGLFVAMLLNFVLALFGVDTGLRSGGPIAIGFSLVCIVVAALSFVLNFAQIEEGIRAGLPERYSWTAAFGILVGLVWLYLEVLRLLSYFQGDD
>NZ_CP022961.1|WP_095563827.1|1063331_1065074_-|hypothetical-protein
MARTHRLDLAVGLLFLLAAGWITHGLWPAPPSRVLALNPADQTLYEWFLASDARLLLGDFSLLSDRLNVPDGVNLMANTTVLALGMVFAPVTLLFGAATTFALIAAGNLAGTAVAWYLLFSRTLRASRLAAALGAVLCGFGPGMVSQSNSHLHMTAQWLVPVMVWLVLRMVRAADPADPAGRVGPDWRRVLTSALGLAGAVTLQVFIGEEVLFLTAVTLTIVTVVYGLTSPRLAWRVLPGLVLGLATAALLAIAVLMIPLWFQFRGPQGVRNGMFSPHHFSADLASFPAFSPLSLAGTASAERLSTGASEYNSFLGWPLLVLALAAALWLARRRIVLACVAAAVVMTALSLGPHLVVNGHRTDITAPYTLLLDLPVVDGALPIRFALAVTPLLAIVLVVALDRARALRWSRARWVAPAVLAAAILPVLPGPLPTTGRPPVPEFFTAGHWRDCVRPTGVLVPVPLPTPNAPWAMRWAAVENVGFAMPEGFFIGPYGDEHGASLGVYKQPTSALLAEVGRSGTIPRIGPTQRERARQDLEFWNASCVVLADDAPHPESLRSTVEALLGPATRDIDVWVWRVR
>NZ_CP022961.1|WP_095563835.1|1075861_1076047_-|hypothetical-protein
MMERDERPVRVPVSLDAWRWPVRIGDLVCGECDVTLRIHQFTAMSELAAAIERHALVCVMS
>NZ_CP022961.1|WP_157756602.1|1076496_1077288_+|helix-turn-helix-domain-containing-protein
MSEHQGLPARLRELRAARRMAQDRLAEAIGVSKSLVSQFESGKAIPQAGTAQRLDELFGTGTEIQEQARTAHEDLRPWMRPWHEHERRAYLLRIWEPMLIPGLLQCEPYMWAVFSAVPRNAGRIDTLMAARRERQANTINREHPTPVPVSTIIGEIALRRGPRDVLKAQLGHLADVTHQRHVKVRVVPIDGEGIHVGLSGPFHIATLPDGRRFGQMDDQLIGHPVTGAGDLGHLELAWEEIDALALPVIQSRDLILRILDEYK
>NZ_CP022961.1|WP_095563837.1|1077274_1077469_+|DUF397-domain-containing-protein
MSTSEPRWRTSSRSNGTGACVEVADNLPGRVLVRDSKDRSGPVLAFAPAAWSAFVAGTPRRSRR
>NZ_CP022961.1|WP_095567576.1|1077746_1078340_-|hypothetical-protein
MTNQNSEVRADFDRRVGSVRGRRVLSVGYWDLSGMGTDAEWDFGDWHHAVMGVQLTTDAGPVTVTWTATFYPYGVEVFPQPIDRHVDREGSQRVGPSTDSRWTAVLGQPVRDARVSWERFTVGPALRSDGQVIGRPHDVDVPTALRLDFAGGSVWFVAGMPQFPEPERVFIPGDEIVVVFTPSKMRQMGFTDPTFTE
>NZ_CP022961.1|WP_095563838.1|1078490_1079150_-|peptide-methionine-(S)-S-oxide-reductase-MsrA
MFLRRMTPQMPSPDQILPGRQTAMPVSDRHAVLGGPLQGPWPEGTRTAVFGMGCFWGAERLFWSLPGVLSTSVGYAGGQTPNPSYEEVCSGFTGHTEVVEVVYDPSIIDYQDLLKVFWENHDPTQGMRQGNDVGTQYRSAIYVTDDEQLALAEQSRDAFAPVVAKAGHGEITTEIARLGAYYYAEDYHQQYLAPSKNPGGYCNHGPNGMTCPVGVAKTA
>NZ_CP022961.1|WP_095563839.1|1079456_1080248_+|helix-turn-helix-domain-containing-protein
MAHPPMLELFAGELCRARTAAGLSRAELGELVGCPEVLLAKIEQAIRVPGAEFAQRCDKVLATDGLLTRIRTGLGREVLPPWLRDWSDIEREAVALRSYQPLVVPGLLQTEGYARALLAAGALRGDELEQQLAGRLERQVVLDREPPPRLDAVLDESVLHRLVGGRGVLREQLLRVLALGRRRSVHLHVVPAGAGAYPGLHGAFVLATAADGTDMGYLDGQLAGRVVERPSDVAALRQTWEEVRAEALPHRQSVELIERLTRG
>NZ_CP022961.1|WP_095563840.1|1080273_1080684_-|HIT-family-protein
MAGCVFCSIVRGEAPALMVADEPEVLAFLDTRPVFKGHLLVIPRDHVETLGDLPPAQVGGYFEAVRRFALAVQAGLGAGGSFVAINNRVSQSVPHLHTHVIPRTRGDGLRGFFWPRHRYDSDTDARTYAERIAAAL
>NZ_CP022961.1|WP_095563841.1|1080763_1081906_+|cystathionine-gamma-synthase
MDYGFETLAIHAGQEPDPRTGAVIPPIYQTSTYAQDAVGSPRLGYEYSRSGNPTRDALQQALAALEGGRTGLAFASGLAAEDTLLRAVCQPGDHVVIPDDAYGGTYRLFSRVAQRWGLNWTAAKVSDVDAVAAAIRPGHTRVVWVETPTNPLLGVADIAALAGIAHEAEALLVVDNTFASPYLQQPIAYGADVVVHSTTKYIGGHSDVVGGALITGDAELGEQLAYHQNAMGAVNGPFDAWLTLRGLKTLGVRMDRHCDNAERIADYLAGHAGVAQVCYPGRPEHPGHELAAKQMRRFGGMVSFRAAGGEEHAVRICDSARLFVLAESLGGVESLIEHPGRMTHASAAGSPLEVPADLVRLSVGIETADDLLADLEQALG
>NZ_CP022961.1|WP_095563842.1|1082058_1083444_+|amidase
MRDINATWVGATAKQIARGVRRGDVSATQVVADHLEYIGRADGELSAFRVVRGGEAIVEAEKVDEQDDLANLAMAGVPVAVKENTPVAGVPTWNGSAAARTPVAEFDHEVVRRLRGAGAVIVGVTRMPELGVWGSTDDATAITRNPWNLDRTPGGSSGGSAAAVAAGLVPIAHANDGLGSVRIPAACCGLVGLKPGRGVVPSQVGATDWFGLAEHGILATTVADAALGFAVLAGRAPDKLVPPAGLRVAVSLRSPVRGVRPDAPNRDAVTAASRLLARAGHDTIATDPAYPTSVGLSGIATWLAAVAAESRAAGLDPATLQPRTRRHAALGGFAERRGWVRESDRAAWRDRCLAFFTDNGVDLLLTPALAGPPLPARRWSERSWRSNLTANVRYAPYAAPWNIAGLPALVVPVGLRPDGLPAAVQLVGPPGTELLLLAVAGQFELAQPWSRHAPGHPRTAD
>NZ_CP022961.1|WP_095563843.1|1083541_1084762_+|threonine-ammonia-lyase
MTELVDLADVRAARDLLAGVTRTTPLEPSRPLTAALGGPVWLKCEHLQRAGSYKVRGAYVRISRLGPAERARGVVAASAGNHAQGVALAAGLVGTAATVFMPINAPLPKVAATKGYGARVELAGATVDESLLAAREFAERTGAVFIHPFDHRDVIAGQGTLALEILEQCPDVRTIIAGIGGGGLISGLAVATKAVRPDVRLVGVQADGAAAFPPSLRAGAPVRLPSYSTIADGIAVGCPGDLTFAHVAKLVDEVVTVSEEDISRALLMLLERTKQVVEPAGAVGVAALISGAVRVETPAVVVLSGGNIDPLLLLRVIEHGLAAAGRYLRLTVRCSDRPGQLASLLSQIAEHRGNVVDVEHQRHDPHLRLGEVGVALSVETRGAEHSDRLVRALRASGYQVSIAEPV

Crispr_ID: NZ_CP022961_8

• CRISPR_ID: NZ_CP022961_8
• CRISPR_location: 1402134-1402215
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_8

Consensus_repeat	Method
TCGCCGGTGGTGCCCGGGTCGTCGG	CRISPRCasFinder

spacers of NZ_CP022961_8

>8.1|1402159|32|NZ_CP022961|CRISPRCasFinder
TGGTGCCCGGGTCGTCGGTGGTGCCGGACGGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_8

CRISPR arrays

The CRISPR arrays of NZ_CP022961_8

>merge|NZ_CP022961|8|1402134-1402215|CRISPRCasFinder
GTGCGGGTGCCGGACGGGTCGCCGGTGGTGCCCGGGTCGTCGGTGGTGCCGGACGGGTCGCCGGTGGTGCCCGGATCGTCGG

>NZ_CP022961|8|8|1402134-1402215|CRISPRCasFinder
GTGCGGGTGCCGGACGGGTCGCCGG	TGGTGCCCGGGTCGTCGGTGGTGCCGGACGGG
TCGCCGGTGGTGCCCGGATCGTCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095564045.1|1405133_1406048_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP022961.1|WP_095564048.1|1412775_1413198_-|hypothetical-protein	unknown	unknown	gnl|CDD|184918
NZ_CP022961.1|WP_095564039.1|1392850_1393879_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP022961.1|WP_095567619.1|1411821_1412625_+|FAD:protein-FMN-transferase	unknown	unknown	gnl|CDD|376782
NZ_CP022961.1|WP_095564044.1|1402738_1403479_-|Clp-protease	unknown	unknown	gnl|CDD|223616
NZ_CP022961.1|WP_095564037.1|1383793_1385944_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|226482
NZ_CP022961.1|WP_095564047.1|1411246_1411783_+|hypothetical-protein	unknown	unknown	gnl|CDD|226484
NZ_CP022961.1|WP_095564041.1|1395546_1396461_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP022961.1|WP_095564043.1|1397335_1399732_+|alpha-xylosidase	unknown	unknown	gnl|CDD|236731
NZ_CP022961.1|WP_157756634.1|1412632_1412779_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095564042.1|1396457_1397309_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP022961.1|WP_095564046.1|1408699_1409362_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133407
NZ_CP022961.1|WP_095567617.1|1408118_1408610_-|DUF4188-domain-containing-protein	unknown	unknown	gnl|CDD|316352
NZ_CP022961.1|WP_095567615.1|1382823_1383528_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095564036.1|1382214_1382763_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP022961.1|WP_095564038.1|1386576_1389561_+|carbohydrate-binding-protein	unknown	unknown	gnl|CDD|178629
NZ_CP022961.1|WP_157756632.1|1381540_1381981_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095567616.1|1406093_1406741_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP022961.1|WP_095564040.1|1394154_1395456_+|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270452
NZ_CP022961.1|WP_095567618.1|1409709_1411230_+|ferredoxin-reductase-family-protein	unknown	unknown	gnl|CDD|99795

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095564045.1|1405133_1406048_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	9.78384e-89
NZ_CP022961.1|WP_095564048.1|1412775_1413198_-|hypothetical-protein	gnl|CDD|184918	PRK14954, PRK14954, DNA polymerase III subunits gamma and tau; Provisional.	0.000137914
NZ_CP022961.1|WP_095564039.1|1392850_1393879_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.06277e-67
NZ_CP022961.1|WP_095564044.1|1402738_1403479_-|Clp-protease	gnl|CDD|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	1.03632e-15
NZ_CP022961.1|WP_095564037.1|1383793_1385944_-|AAA-family-ATPase	gnl|CDD|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	7.62853e-44
NZ_CP022961.1|WP_095564047.1|1411246_1411783_+|hypothetical-protein	gnl|CDD|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	0.000204572
NZ_CP022961.1|WP_095564041.1|1395546_1396461_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.91726e-81
NZ_CP022961.1|WP_095564043.1|1397335_1399732_+|alpha-xylosidase	gnl|CDD|236731	PRK10658, PRK10658, putative alpha-glucosidase; Provisional.	0
NZ_CP022961.1|WP_095564042.1|1396457_1397309_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	9.56183e-64
NZ_CP022961.1|WP_095564046.1|1408699_1409362_+|MerR-family-transcriptional-regulator	gnl|CDD|133407	cd04780, HTH_MerR-like_sg5, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 5), N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.72025e-30
NZ_CP022961.1|WP_095567617.1|1408118_1408610_-|DUF4188-domain-containing-protein	gnl|CDD|316352	pfam13826, DUF4188, Domain of unknown function (DUF4188).	4.39273e-61
NZ_CP022961.1|WP_095564036.1|1382214_1382763_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.27492e-10
NZ_CP022961.1|WP_095564038.1|1386576_1389561_+|carbohydrate-binding-protein	gnl|CDD|178629	PLN03080, PLN03080, Probable beta-xylosidase; Provisional.	3.06686e-60
NZ_CP022961.1|WP_095567619.1|1411821_1412625_+|FAD:protein-FMN-transferase	gnl|CDD|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	8.63263e-53
NZ_CP022961.1|WP_095567616.1|1406093_1406741_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	9.08908e-15
NZ_CP022961.1|WP_095564040.1|1394154_1395456_+|extracellular-solute-binding-protein	gnl|CDD|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.69435e-45
NZ_CP022961.1|WP_095567618.1|1409709_1411230_+|ferredoxin-reductase-family-protein	gnl|CDD|99795	cd06198, FNR_like_3, NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	1.53283e-52

Protein sequences

>NZ_CP022961.1|WP_095564043.1|1397335_1399732_+|alpha-xylosidase
MKFTDGYWRKRDGLTVLHPVQMVDASADAHSLTVYAAARPVRSREHTLDAPIITVSCTSPMPDVIRVTIGHFLGERPRQPSFQIADDPDTPVEAAVDEAGATFTSGALTARFSGDDGWRLDFVADGRVLTGSGRKGMGIVDVTAGPEPYDRAAGHGADAVVGRDGPDPYGARHYVHEQLDLGVGEAVYGLGERFGPLVKNGQSVDIWNEDGGTCSEQAYKNVPFYLTNRGYGVLVDHPGRVSFEVASEVVSRTQFSVAGQTLSYLVIYGRTPLEVLRRYTALTGRPALPPSWSFGLWLTTSFTTPYDEETVTKFVAGMAERDLPLSVFHFDTFWMKEFHWCDFEWNSEIFPDPPGMLARLADRGLRISLWINPYIAQRSAMFAEGAAAGYLLRRPDGDVWQWDRWQAGMALVDFTNPDARAWYAAKLRALLEMGVDCFKSDFGERIPLDVEYFDGSDPERMHNYYTHLYNETVFETLRDYRGEHEAVLYARSATVGGQQFPVHWGGDNSATFESMAETLRGGLSLAACGFGFWSHDIGGFEGRPDPAVFKRWIAFGLLSSHSRLHGNQTYRVPWLFDDEAVDVLRQFTRLKCRLMPYLFGAAVQSHRAGAPMLRPMAMAFPDDPACVYLDRQYMLGDDLMVAPVFSADGDTSYYVPAGRWTRFLDGSTVEGPGWVRETHGFDSVPLLVRPGAALALGAREDRPDYDYADGVTLRLYGVPDGTRTVTVPAADGTDAATFEVRREGATIRVQRRGEPAPWRVLVVGERAAAPADGVSSTGSGVLVEPPAGAASCEIRLAG
>NZ_CP022961.1|WP_095564042.1|1396457_1397309_+|carbohydrate-ABC-transporter-permease
MTALPTVRQRRRRPARFLVLALLLVAVLLVIAPMLVVALNAVKSPADYASNGPLALPRSLHLSGIVDFWHRVDFTRKLLNSLVISLTVAVLGVGLSVLNAYALGIGRIRGRIWFLVFFLVANLLPQEVLAYPLYYISKSLHLYDSLTAVIIIFTVIQSAFGTYLLASVYLEFPTELLDAAAVDGAGRWRTLWQVVVPVSRPTLAVLFTFFFVWTWNEFFLPLIFLVSKDTQTVPVALGVLQGDRQMDATTTSASALIGILPALIFFLIFQRTLTRGIAAGAIK
>NZ_CP022961.1|WP_095564041.1|1395546_1396461_+|sugar-ABC-transporter-permease
MTGGGGSRRGGYVVFLIPGVVAAVAVIVVPLVMTIGISFTRWTGIGSPEWVGLDNYTRLFADANFWASFGHILALIVAMAVIPTLLGLILAAVLFDYVAPAFSNRWASAFRSGFYLPQVLPVAVTGIVWGWILHPSYGALNRILDSAGLHGLARNWLGDPKYALPSVMAVMVWVQLGYPVVMFMAGLQRIDPELYEAASLDGAGWWQRFRRITVHLIRPEFYVVLVTTTIAALKIFGQIFVLTRGGPSNATLVPSYFAYKNFFEKFNVGYGSAISTVLTVLIVGLAIVFLRLQDRDQRSGTGQR
>NZ_CP022961.1|WP_095564040.1|1394154_1395456_+|extracellular-solute-binding-protein
MVRSRASMAAGALLLAASLAVSACGSSDDEGSDAKTLTLWHYEGPNSAMGIAWNEAINQFKSSHPGVEVKFEEKSFEQIQQNAGMILNSDSAPDVMEYNKGNATAGLLSKQGLLTDLSDQASKRGWDKALSPSLQTTARYGPDGIMGSGKFYGVPNYGEYVMVYYNKDLFDKHKVQVPTTFAEFETVLDTFVKDGVTPISVGGAEYPAQQIFYELALSKADRGFVDNYQLYKNKVDFHGPELSFGAQTFADWVKKGYLDKNSASIKAEDMGVAFEQGKFPIMISGSWWYGRFTKEINKFQWGTFLFPGNKLHPGSSGNLWVVPAKAKAKSLAYDFIDITMKPDVQNLLGNNGGIPVAADTSKIEDAKNKELIDNFASISSSDGLAFYPDWPAPGYYDVLVGGVQGLINGSKSPDAMLDEIAKPYEDNLADIGK
>NZ_CP022961.1|WP_095564039.1|1392850_1393879_+|LacI-family-transcriptional-regulator
MATISDVARAAGVSASTVSYVLSGRRPISAETRARVQAAIAELRYHPHAGARALASSRTSVLALVVPLRLDVNVPVIMQFVTAVVTAARAHNHDVLLLTKDEGTAGLERVAGATMVDALIVMDVERRDLRIPALRRLRQPSVLIGLPEDPAGTACVDLDFDAAGRECLRHLAGHGHRRVALVGPTPVVYARHTSYADRFLVGFQAAAAELGVQAVTRACEPGGDGVRACLAAIDAELAGVTALVVHNEEALLPLLDELRMRGRRIPTDISVVAVCPRDVAVGLPVPLTSVDIPAHEVGTLAVEMAMGLLDGQGTSATRLLPPTLVERESCGAPAVPRNRRRR
>NZ_CP022961.1|WP_095564038.1|1386576_1389561_+|carbohydrate-binding-protein
MRKRRLRRGVTGLVLALLVLPAVPGTALAEPTYPFRNPDLPLNTRVDDLLGRLTLDEKISLLHQYQPAIPRLGIDLFKTGTEALHGVAWSTDIDNGGAVVTAEGTSFPQPVGMASTWDTDLIQRVGSAVGDEARGYHAVNPRVWGLNLWAPVVNLLRDPRWGRNEEGYSEDPTLTGAISTAYGSGMTGDDPDHLKAAPTLKHYLAYNNEVLRDVTSSNVPPRVLNEYDRAAFKPAISADAATGVMASYNLVNGRPATVDPDLATVVRSWTDRPLMNVTDAWAPNNLTASQAYYATQAEANAAIIKSGTNSFTTDDTNAEPTTTAVREALNQGLLTEQDIDARLRETLNLRIRLGEFDPGGGPYGGITPDVINSPEHQQLARQAADEAMVLLKNSRNALPLNADRTRSVAVLGPLGDTLYSDWYGGFLPYQVTALDGIRERLGGSASVTGVDGADRIALKDNATGRYVTATGTTDADTVTATGESATPAAQFDSVDWGQGVLTLRNVENGRYLGYNWGPFITRDDQPNGWFVQQQFKLEAQDDGSYVLHYAGYESTESWFGPNTYITVGDDGALTLGAANAANAAHFSREVISSGIDRAVAAAKAADTAVLVVGSNPFINGREAHDRTTMALGASQEALVKAVTKANPHTVLVLQTSYPDTITWEQEHVPAIVWTTHAGAETGHAIADVLFGDHNPSGKLTQTWYRSDEQLPSDLLDYDIISSRQTYLYSHAKPLYAFGHGLSYTRFRYGNLRTNTHSVGADGTITATVDVTNTGSRAGAEVVQLYTHQRTSRDATAIRALRTFQRVDLAPGQTRRVTLRVPVADLAHWDVTRSRWVVEDSTYDLMVGSSSTDIRQRAAVRVHGETIPPRDLSRPTRAENFDRYAGVSLVDQSKAAGTAVGAGEAGQWVSYAHADLRRGAGTFTAKVARAAAGDGTIEVRLGSPTGRLLGTATVPSTGDKYTYATTSATLARSGGIQDVYLVFGSALRLSEFSIR
>NZ_CP022961.1|WP_095564037.1|1383793_1385944_-|AAA-family-ATPase
MTTVTTDAFDLPDHLAAKADPALIAADQRHFAAIAETLARSIAEVSEQLAAARRAPGGKGRQAVDRDQAVRRLAARQRALRRFGLDLCLGRMIRADDAEPVYVGRFGLTGSDGRRLLLDWRSPAAEPFFGATHANPMGLVSRRRYRWTLGRISDYWDEVFTPDGLAGHAALDDQSAFIASLGVHRSARMRDVLATIQADQDAIIRAGSRGALVVDGGPGTGKTVVALHRTAYLRYADPRLGPGRGGVLVVGPHQPYLAYVADVLPSLGEEDVQICTLRDLVAEGATAIDEDDPRVARLKSSADLVRAIETAVRFYEEPPGTSMTVAVAGTEIRLNAGDWADAFDAAGPGTPHNEAREQIWAELLTILLNRYGGDEPTEVVRGWLERNRELRAALQRAWPLLDPADIVADLWSVPAYLHRCAPWLDRDEIRALQRPDPRAWTVADLPLLDAARQRLGDPAAALRQRRYDAGVAGQRARMSRVIDDLLDADAYDDGEGLFTMLRGQDLRNSLVDRDGLPDTEPDRLAGPFAHIVVDEAQELTDAQWQMLLLRCPSRSLTIVGDRAQARHGFTESWSERLRRVGLDRIALASLSINYRTPTEVMARAEPVIRAALPDANVPTSIRSSGIPVTQGAAAELGPILDAWLAAHAEGIACVIGDPGFPDTPRVRSLTPEGSKGLEFDLVVLVDPERFGEGIEGAVDRYVAMTRTTQRLVLLTT
>NZ_CP022961.1|WP_095567615.1|1382823_1383528_-|hypothetical-protein
MAVTLAAALAGCAEAEETDGQGASSAPAPSATTVGVDPSPSPSASATVTIPKSAFLDLPAELRKSPAQATDVAQALPQLCGNEFGSGGRSVTASAAMMRDYKLPTDPPENVPYGTIAQTVFAFEGSGAADYLQRVRGAVESCPSFDREDAKVTVTSKPMSGIGDEALLVTLTWPGTNLDGTPTGGKATSQVVTIRVADAATVLYDQGWEGASNKPDLIDDFARAAVRGLDGWQG
>NZ_CP022961.1|WP_095564036.1|1382214_1382763_+|GNAT-family-N-acetyltransferase
MTARQPLTIRPGGPDDAATVLRLLDIATAWLVERGRTGQWGTGPASTDPRRIAQADAWATSGGLYLAMLGDAAVGALAVGGAGAFVPPATEPELYVRLLVTDRAYAGHGIGARLLAYAEELARDRGVRLLRVDCYGGDDRELVRFYVGCGFTPTDAFLVQRPGLPPWPGQLLIRRLADREPG
>NZ_CP022961.1|WP_157756632.1|1381540_1381981_-|hypothetical-protein
MTKSKGRPKKGRLADMTSQPPGENCYEPPPDDECEEFAATIDLAPNVRMGTRLVYLRGTSQLVYFAVWQAIKLDGRWERVARVDCHHGTIHRHDFTRSGRNQVTVLAAIPVASGSSELLDRWCTQVESIMQNEWEANVRRWRDDRE
>NZ_CP022961.1|WP_095564044.1|1402738_1403479_-|Clp-protease
MTEPTPPTVSIRLDDLIEGIKRAHPDVLDQLSDAVIAADHLGDVADHLIGHFVDQARRSGASWTEIGRSMGVTKQAAQKRFVPKAPGEGTDLDPSQGFSRFTPRARNVAMAAHDAARTARNPEVRPEHLVLGLMAEPEAVAAHAITAQGVSLEAVREAATAALPPAADQVPELIPYDDQARKTMQLTYREALRLGHNYIGTEHLLLALLEQENGTGPLSGLGIDKAAAEATISAAISKIAISFQQE
>NZ_CP022961.1|WP_095564045.1|1405133_1406048_-|ABC-transporter-ATP-binding-protein
MTAAISIAGLVKTFGRTRALDGLDLSVHTGEVHGFLGPNGAGKSTTLRVLLGLLRADSGTARLLGGDPWSDATALHRRLAYVPGDVTLWPNLSGGEVIDLLGRLRGGLDRRRRADLLERFDLDPRKKGRTYSKGNRQKVALVAAFASDVELLLLDEPTSGLDPLMEDVFRQVIREDLQRGDRTVLLSSHILSEVEALCDRLTIIRDGRAVETGSLTQLRHLTRTTIQADLAGPVDGLADLAGVHDLREQHGRVSFDVDADALDDALRRLTQVGVRSLVSQPPTLEELFLRHYDRSGERPAEVAP
>NZ_CP022961.1|WP_095567616.1|1406093_1406741_-|TetR/AcrR-family-transcriptional-regulator
MGDPSFEDLTARARIRDAAIRLFAERGIEATTIRDIAAAAGVSPGLVRHHFGAKSALRDACDAYVAEQFDRIRKDMFDRDGMADPTFLGAIHPTARLLQNYFVRSLMDGSGAATARLDEAVETGERWLLDHGAKSRDPQAMAAVLAFMKLGVFIMQDQLSRILGVDVNTPQGYVRMLRGMVDVTSQPLLTPEQAEQLHAGLDQLAAKDDGAENAA
>NZ_CP022961.1|WP_095567617.1|1408118_1408610_-|DUF4188-domain-containing-protein
MAPVTKGRMTADLSGDFVVFLIGMRVNKPWKLHKWIPVAKAMLPMLRTLYRNRDLGMLGSHTFLGIHGPMLVQYWRSVEHLDRFARDTSLPHRPAWRAFNRRVGTDGDVGIWHETFEVRAGAYESLYANMPPFGLAAAGRHLPVATKGERAAERRQAGSGQSS
>NZ_CP022961.1|WP_095564046.1|1408699_1409362_+|MerR-family-transcriptional-regulator
MRIGELSRQSQVSVATIKYYLREGLLPAGVASAANQADYTEEHLRRLRLIRALIGVGGLPVARAREVLAAVDAREVAPHHLLGMAQYAIAPPVDAAAEDPDRRRARAEVLELVRRHGWQVDPEAGGIDRVAEAVSALRALGQDDLLELLDTYAEAAAAVARRELAVVVARRDPAAMVEGVVIGTVLGEALLTGLRLLAEQDASARRLGAAPGADGGKPPG
>NZ_CP022961.1|WP_095567618.1|1409709_1411230_+|ferredoxin-reductase-family-protein
MTDRPRRPKPALGRDAARWQEPSAGPGRPTDRGAGVATEPRGADRTYRVKDAYRPRSAQHREIDVPDVYDHSGRLLFTIVFWCALATSVELWWLNTPTGSIRSVADILVAGGRLTGLVGGFLLLTQVLLMSRVRWLERWIGAHSLLIWHRELGGALLFMILGHVALIVVGYSRIAAQPLLPTAWSMITTYEDMVSATLATGILIGISLLAIRSVRRRLPYEFWYFLHLTSYLILLLGYGHQFATGRELSRGGFGTWYWAGLYAFVVLCLIWGRIVAPAWFNLRHRLRVARVTAEGPDMISVYISGRRLDGLDARAGQYFRWRFLTLGCWWQAHPFSLSAAPNEHFLRLTIKVVGDHTERLRGLRPGVRIFAEGPSGVFTAERRRRPRALLIAGGSGIAPIRALLEELPAQTVVIYRARNEDELLFREELDWLAREREAQVWYVLGSRDDAGPRYLFTPKGMRELVDDIRHRDVFLCGPSGLVNTSVRTLRRLRVPRRQIHLDPFEF
>NZ_CP022961.1|WP_095564047.1|1411246_1411783_+|hypothetical-protein
MRRAVFALLGTTIGTSLLIGAKLGQPAQGEAQLTVDTAGAAGADSPSGSPTGDGSAAPAGTPTAKASPTRAGGKTATPAGPKPAGLRNGTYTGAPVTHEYGTIRVTITVAGGVVTKASASYPTDDPTTRAVNEGAVPTLNSRAVAAKTTSTISTVGGATLTSGAYKSSLQSALDKAKA
>NZ_CP022961.1|WP_095567619.1|1411821_1412625_+|FAD:protein-FMN-transferase
MGTAISIQLSDPLPTERLAELAERTFDWLREVDRRFSTYREDSEVNRFHRGELGIDECSPDLRHVLDACADLWRGTDGYFDAYATGRFDPSGYVKGWSVQVASDRLLAAGSSAHWINAGGDIRARGGPRPGEPWRIGIRHPVEGDRVAWVLEVTDLAIATSGTYERGRHVIDPRRGVPASGLGSVTVTGPDLGIADAYATAGLAMGAGGLGWLAGLPAGYEAGVITDELSGFSSAGLPVADDASADDPSAEDGPADDGPADDRGAGS
>NZ_CP022961.1|WP_157756634.1|1412632_1412779_-|hypothetical-protein
MTRGPAGEAELTFAGERKVVRIELRCVRGVPEATVSVRGRGPGNDRPH
>NZ_CP022961.1|WP_095564048.1|1412775_1413198_-|hypothetical-protein
MSGPLRRLATNLVAWLLGAVVSVTVGVLALTRVDEGLANGVQPLSPDSVTRGLPDPPSAAPSRTPRRGATSAPARSPSRRATSAPGRPAPSEPSVPATPPAPRAVERTFTAQGGSLLVRCTAGLVYLASWSPAPATGCWT

Crispr_ID: NZ_CP022961_9

• CRISPR_ID: NZ_CP022961_9
• CRISPR_location: 1448678-1448779
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_9

Consensus_repeat	Method
CGGCGGCTCGCCGAGACCTGACCGGCGCGG	CRISPRCasFinder

spacers of NZ_CP022961_9

>9.1|1448708|42|NZ_CP022961|CRISPRCasFinder
CCGGGACTCTGCGACACCGGCGCGTCCGCCACCGCGGTCTGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_9

CRISPR arrays

The CRISPR arrays of NZ_CP022961_9

>merge|NZ_CP022961|9|1448678-1448779|CRISPRCasFinder
CGGCGGCTCGCCGAGACCTGACCGGCGCGGCCGGGACTCTGCGACACCGGCGCGTCCGCCACCGCGGTCTGGCGGCGGCTCGCCGGGACCTGACCGGCGCGG

>NZ_CP022961|9|9|1448678-1448779|CRISPRCasFinder
CGGCGGCTCGCCGAGACCTGACCGGCGCGG	CCGGGACTCTGCGACACCGGCGCGTCCGCCACCGCGGTCTGG
CGGCGGCTCGCCGGGACCTGACCGGCGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095564079.1|1458377_1460096_-|metallophosphoesterase	unknown	unknown	gnl|CDD|365906
NZ_CP022961.1|WP_095564080.1|1460175_1461375_-|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl|CDD|369642
NZ_CP022961.1|WP_095564068.1|1441946_1442264_-|DUF202-domain-containing-protein	unknown	unknown	gnl|CDD|376882
NZ_CP022961.1|WP_095564070.1|1442814_1443225_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095564066.1|1438039_1441354_-|transcriptional-regulator	unknown	unknown	gnl|CDD|226418
NZ_CP022961.1|WP_095567624.1|1462129_1463056_+|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240643
NZ_CP022961.1|WP_095564067.1|1441454_1441823_-|hypothetical-protein	unknown	unknown	gnl|CDD|379161
NZ_CP022961.1|WP_095564082.1|1463049_1463451_-|PH-domain-containing-protein	unknown	unknown	gnl|CDD|371225
NZ_CP022961.1|WP_095564065.1|1436003_1437923_-|hypothetical-protein	unknown	unknown	gnl|CDD|370572
NZ_CP022961.1|WP_095564077.1|1455042_1455348_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl|CDD|178810
NZ_CP022961.1|WP_095564073.1|1446597_1447668_+|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NZ_CP022961.1|WP_095564075.1|1448846_1449221_+|VOC-family-protein	unknown	unknown	gnl|CDD|380093
NZ_CP022961.1|WP_095564078.1|1456832_1458332_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl|CDD|235489
NZ_CP022961.1|WP_095564076.1|1449264_1450260_+|hypothetical-protein	unknown	unknown	gnl|CDD|377122
NZ_CP022961.1|WP_095564069.1|1442260_1442653_-|DUF202-domain-containing-protein	unknown	unknown	gnl|CDD|225060
NZ_CP022961.1|WP_095567622.1|1444256_1445216_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP022961.1|WP_095564081.1|1461502_1462054_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095567623.1|1452649_1454860_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|236645
NZ_CP022961.1|WP_095564071.1|1443464_1444244_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|238847
NZ_CP022961.1|WP_095564072.1|1445344_1446523_+|cysteine-desulfurase	unknown	unknown	gnl|CDD|224029

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095564079.1|1458377_1460096_-|metallophosphoesterase	gnl|CDD|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	5.4891e-12
NZ_CP022961.1|WP_095564080.1|1460175_1461375_-|PQQ-dependent-sugar-dehydrogenase	gnl|CDD|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	6.44006e-92
NZ_CP022961.1|WP_095564068.1|1441946_1442264_-|DUF202-domain-containing-protein	gnl|CDD|376882	pfam02656, DUF202, Domain of unknown function (DUF202). This family consists of hypothetical proteins some of which are putative membrane proteins. No functional information or experimental verification of function is known. This domain is around 100 amino acids long.	3.18688e-07
NZ_CP022961.1|WP_095564066.1|1438039_1441354_-|transcriptional-regulator	gnl|CDD|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	1.46327e-62
NZ_CP022961.1|WP_095567624.1|1462129_1463056_+|2-hydroxyacid-dehydrogenase	gnl|CDD|240643	cd12166, 2-Hacid_dh_7, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.01929e-143
NZ_CP022961.1|WP_095564067.1|1441454_1441823_-|hypothetical-protein	gnl|CDD|379161	pfam13396, PLDc_N, Phospholipase_D-nuclease N-terminal. This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, pfam00614. However, a large number of members are full-length within this family.	5.03258e-05
NZ_CP022961.1|WP_095564082.1|1463049_1463451_-|PH-domain-containing-protein	gnl|CDD|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	5.86745e-09
NZ_CP022961.1|WP_095564065.1|1436003_1437923_-|hypothetical-protein	gnl|CDD|370572	pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	6.84075e-08
NZ_CP022961.1|WP_095564077.1|1455042_1455348_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl|CDD|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	7.94667e-36
NZ_CP022961.1|WP_095564073.1|1446597_1447668_+|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP022961.1|WP_095564075.1|1448846_1449221_+|VOC-family-protein	gnl|CDD|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	8.25848e-25
NZ_CP022961.1|WP_095564078.1|1456832_1458332_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl|CDD|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP022961.1|WP_095564076.1|1449264_1450260_+|hypothetical-protein	gnl|CDD|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	5.73519e-42
NZ_CP022961.1|WP_095564069.1|1442260_1442653_-|DUF202-domain-containing-protein	gnl|CDD|225060	COG2149, COG2149, Predicted membrane protein [Function unknown].	4.17164e-22
NZ_CP022961.1|WP_095567622.1|1444256_1445216_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	7.27273e-107
NZ_CP022961.1|WP_095567623.1|1452649_1454860_+|EAL-domain-containing-protein	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.93933e-109
NZ_CP022961.1|WP_095564071.1|1443464_1444244_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	3.85914e-86
NZ_CP022961.1|WP_095564072.1|1445344_1446523_+|cysteine-desulfurase	gnl|CDD|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	8.59119e-167

Protein sequences

>NZ_CP022961.1|WP_095564073.1|1446597_1447668_+|tRNA-2-thiouridine(34)-synthase-MnmA
MRVLAAMSGGVDSAVAAARAVDAGHDVTGVHLALARNPQTYRTGARGCCTLEDSRDARRAADVIGIPFYVWDLADRFHADVVDDFVAEYAAGRTPNPCLRCNEKIKFAAVLDRAVALGFDAVVTGHHARLGPDGLLRRSVDLDKDQSYVLAVLTRDQLDRSIFPLGGSTKAQVRAEAADRGLAVADKPDSHDICFISDGDTRRFLAERLGEEPGDIVDGRTGAVVGTHTGAYAYTVGQRRGLALREPAPDGRPRYVLSITPVTNTVTVGPAEALAVSTVSAQRPVWTGGARPDGPVECRVQLRAHGSVVPATVRCDDTGLHARLHEPVRGVAAGQAIVAYRPDPAGDVVLGSATIR
>NZ_CP022961.1|WP_095564072.1|1445344_1446523_+|cysteine-desulfurase
MAYLDHAATTPMLDEALEAYVATVREVGNASSLHGAGRCARRRVEESRERIAAAVGARPSEVIFTGGGTESDNLALKGIFWARRAADPARTRVVVSGVEHHAVLDAAHWLGDHEGATVSLLPVDEAGRIRVDALGELLDAYPGEVAVVSTMWANNEVGTVQPVAELAAVASRAGVPLHTDAVQAVGQVPVDFAASGAAALTLTGHKLGGPVGVGALLLGRDVACTPLLHGGGQERDVRSGTLDTAGVVALAVAVETAVKRQQEYAARLRGLRDELIERVRAAVPDAIVNGDPADRLPGNAHLSFPGCEGDALLLLLDAQRISCSTGSACSAGVAQPSHVLLAMGADDARARSSLRFSLGHTSTPADVEALVAALPAAVDRARRAAAVRDRRS
>NZ_CP022961.1|WP_095567622.1|1444256_1445216_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAEVLVVVEATKEFGVKKVTLEQLTLARDLGTPAAVVLGGPGAAEALAGKLGEYGAAKVYAGESEEIDGYLVAPKAAVLADLVNRVQPAAVLLASSQEGKEIAARLAVKLDNGLLTDVVGLAADGTASQLAFAGSTIVKSTVTRGLPLVTVRPNSINPTPAPATPQIERLDVRVADADKLAKVVERVAEQKGSRPELTEASVVVSGGRGVGNADNFKLVEELADLLGGAVGASRAAVDSGFYPHQFQVGQTGKTVSPQLYVALGISGAIQHRAGMQTSKTIVAVNKDGEAPIFELADFGVVGDLFKVVPQAAEEIRKRR
>NZ_CP022961.1|WP_095564071.1|1443464_1444244_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNIVVLVKQVPDSGADRNLRSDDNTVDRGSASNVINEMDEYAIEEALRLKEANGGEVTVLTMGPERAAESIRKALSMGPDKAVHVTDDALHGSCAPATSKVLAAALRRLGADLVLCGAESTDGRVQVMPHMLAERLGIAALTGARKLTVEGGTLTIERQTEEGYEVVTASTPAVVSVWDTINEPRYPSFKGIMAAKKKPVETLSLADLGIPADEVGLAGATSAVVEHSKRPPRSGGQKVTDEGSGGVALVEYLATEKFV
>NZ_CP022961.1|WP_095564070.1|1442814_1443225_+|hypothetical-protein
MTVDDRLAADERMTLKTAAYGAVFLVSNAEPGPFAMIKESFAASDTIAGSSGLVRDVLTTGPLPQLPADPVAVKEVVLPALRRSVELLREHAPAELGRYQATVVAAAHQVARASAGTSEAEATALAEVLAALEVTP
>NZ_CP022961.1|WP_095564069.1|1442260_1442653_-|DUF202-domain-containing-protein
MWSAIRQWFDPHELREVGSTPDYRFSLANERTFLAWLRTGLALIAGGLGVAQFLPRMPVQHLREALAAALLLLGAVVAVRAVDHWARTERAIRLGEELPVSRFPAVLALVVGLGAVVLIVLLLATGGPGR
>NZ_CP022961.1|WP_095564068.1|1441946_1442264_-|DUF202-domain-containing-protein
MTGDPGLQPERTRLSWRRTALAHAVVVLLLVRLALRHGPAGALPAVAAVAAVAGWALVVTVSYRRMAGDPRDRAPERVPAGGAALPVAAAVAAGYAVLGIVLLVR
>NZ_CP022961.1|WP_095564067.1|1441454_1441823_-|hypothetical-protein
MVRVLMLLFLVELVLTGLAMVSCLSVESGRSIRVLPRAAWVVVILILPIAGAVAWFTAGRPAPARTPVARPARTGPAAPDDDPEFLRSLARRDRRERELFERWESDLGGPDAASGEGTDPPR
>NZ_CP022961.1|WP_095564066.1|1438039_1441354_-|transcriptional-regulator
MQIAVLGPVAVVGDDGTPVPVAGTRLRRLLILLALDPGRVVATGRLVAGLWAGSPPAAAANALQALVSRLRRILPDGAVESHPTGYRLAVPAEAVDLVRFERLAATGRRLLPTDPGRADAVLTEALDLWRGPALADLDGAEVTAGLLARIDEVRLGAVEDRIQARLALGAADALVPELRDLVTAYPLRERPAAQLIRALRAAGRTAEALSAYERFRAELADQLGVDPSAELAALHLDLLRTPDPAPTLGGPAGADRAGADRARAPGAGPATAPRDRATGPADAAPPPVTSNLPAPLSSFVGREQDRARVAALVRASRLTTLTGPGGAGKTRLAVESGRALLGDAPGGVWLVELAPVTDPDEVPHTVLSALGLREQALVAGNRARVPAAEPVDPIDRLAAAIGSRRLVLILDNCEHLIDAAARLAGRLLGACPQLRVLATSREPLGITGEALRPVDSLALPPPDVGAERAPDYPAVRLLIDRAAAVRPGFAVTADTVAAVAGICRALDGMPLAIELAAARLRSMTPAQLAARLDDRFRLLTGGSRTALPRHQTLRAVVDWSWDLLDGSERALLRRLSVFAGGATGEAVERVCAGPDLAAEDVFDRLTALVDKSLVVLVDGPAPRYRLLETIREYGLSRLVEAGEADRVRRTHAEEYLAVAEAADAHLRGPDQLAWLGRLSAEHDNTITALRWAITADKATAIRFVAALGWYWWLRGHRVEGVGYARQVLGDPEAEAQAPAESYAHAYAVTAMLVMAAGQGDLAEGQAWLSRAAALAGPHRAHNPLLRLIEPTAAAIESYFSGPQLDIMDRLFDDPDVWVASTARIFHALSEQNLGRPDETAAAHLRAAAAGYAALGERWGSAFSLMGLADLISRRGDHGQAAECYQQALRMLHELRIAEDVPEVQARLAHELWHLGEHTRALELLAEAEREAERLGSDDSRAAVVYTHADILRSTGDWPAARERLDRGAELLEGKRTAQQTRAVFCSSRAVVAGADGDLAAARTMHAEALRLAFDSHDAPVIGIVLVGYADLALRAGRPESAAVLLGAAAGVRGGGPDRSLLDGRRIEAAVREALGPAGFADAYARGLPTTADGAAELVRAALDG
>NZ_CP022961.1|WP_095564065.1|1436003_1437923_-|hypothetical-protein
MMTASETAAASPPVADAGSPGSVPPAEPAAATGDVALVDGPAPVAAAPGTAGDPGGASGTAEGRIRAAWRWLPDLAAVLAYLGAAMVLTGRLWRDPTGRASGANPTDATLFHWMLAHSARVVSHLENPLLSDRMNQPEGINVMANTSILGLGLPLSPVTMIWGPAVSFLVVVVTALAGTAVAWYFVLSRHLTESRLAAFVGAALAGFCPGMISQAGGHPHIAVQFLVPLILAGVLRLGASTRPVRHGVILGLLIAYQVFLGEETLFITALVGAIVLVAWVIQRRREVGRRWRPFLIGTATAGLVAAVLVAYPLYVQFFGPGNYRHVPGIKNYGADLLSFVNYSPYSLGGDPEAPLRLARNTTELNTFYGWPLLIAVLTIAVWLRRHLWVRIATVVAVVLIPLSWGYDILIDGRYTGVAGPWAPLVEAPLFESVVTSRLGIMVGAAFGVLVTMALTELLRGDLRRPLRIALGLLLVGTMLPLIPRPLPISPAVRMPVSLADGRWRDYLSEDAALMPVPPQKPEVVRTMAWAANTGLGFKVSHSYVLGPDPVRGGGWAQFHTDPNATDTILNTVASTGQPATITDAERAQARVDLRNRHVGLLALTTTRGNAGALKTTVDDLLGQSGQRVGGMWLWKVDPN
>NZ_CP022961.1|WP_095564075.1|1448846_1449221_+|VOC-family-protein
MIGQLRTVVIDCPDPRALAGFYAQLLGLPVTFDDGDDPDAWVVLGGKPGELPRLAFQRALDLLPPAWPDPARPQQFHLDVTVEDVDEAEPQVLALGATRLTAVDDEHFRVYADPVGHPFCLCWD
>NZ_CP022961.1|WP_095564076.1|1449264_1450260_+|hypothetical-protein
MTPRRASGSLFGLAYGDALGKPTEFLPVAEIVARYGPAGPRELAGDPALVTDDTQMALAVAWSLREAPAAAPAALEAALRRRFVAWAQSPENDRAPGMTCLRACAALADGRPWQAATVAGSKGCGANMRVTPVGLVAGFDLDTLAGVAQLQAGLTHGHPTALAASELTAYAVRLVRDGAAPADLPALLRARAAAQRRVYRYDWLGDLWQRPGLTDPADFIERGWVDCLAALDRLDAALAGPDDGGDPCEATGEGWIAEEALATALLCVLRQPADPVAVLARAATTAGDSDSIAALAGAVLGALHGMPAWPAEWAGRIEYADQLDALGSELD
>NZ_CP022961.1|WP_095567623.1|1452649_1454860_+|EAL-domain-containing-protein
MEKRRDVKGRADRAGVGRCHGGRIAAELRSPGRARAFFGFVWTVVAVATALSAAPLAALPDRVPALPAAFWLMAVLAVAGDAHPFTPSGQRPSPAVFPSICFSFAILLGWGLGPAVAVQTLAVVVASWRMRHAVWRAAFNAGQYALALFAAREVARLAVPAGFAAGFAVTWRDVLAVAAGGAAWFLVSYGLVTLALRMRFGVRWWSVFRQGFAFEAVSNSSLLLLGPVLMAAARLSAALIPLIVVPLYAVSRMARLAGEQERQARLDPLTGLANRKALLLEVAERISLHAERAAKGEPSRLALLLLDLDRFKHVNDALGHAVGDRLLVEVGRRLTAAVRPGDMVVRLGGDEFAILAGGLHDIEAAREIADGVVQTLTEPVPLDGLPLDVGGSIGVALYPEHGHDFETLMRHADVAMYDAKHRGDTVAVYAAESDHNSPERLSLLADLRQVLEAPGAGTAEDVGEITMYYQPQIAIATGEVVGVEALLRWRHPRRGMVDPEELIRVAEQSAVMRLLTRRVVDDVVEQIAAWSASGLRLRAAVNVSVRDLHTGEIADQIADRLARFDVPPAQLQLEITEGALMADPRRVLATISRLDKIGVAISLDDFGTGYSSMQHLRRLPLAEVKVDRSFVLGMAVDADDAAIVRSMIELAGALGLRVVAEGVEDDRTWRLLYAAGCDVAQGWFYARPMPAAELASWLSRYRPLRPGPVQESSGRHRWPTASIRGLRVDQGRADVT
>NZ_CP022961.1|WP_095564077.1|1455042_1455348_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MAAISREEVAHLARLSRLAVTEEELGTFAGQLDVILQSVARVGQVAAADIPPTSHSVPLTNVLREDVVTPCLTPEEALSGAPDADQQRFRVPRILDEEAGS
>NZ_CP022961.1|WP_095564078.1|1456832_1458332_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTTTLPAYDEVVTRYEPVIGLETHVELGTRTKMFCGCPTDFGGEPNTRVCPVCLGLPGSLPVANKAAIEATIRIGLALNCSIAQWCRFARKNYFYPDMPKNFQISQYDEPLCVDGYLDVEIDGETVRIGIERVHLEEDTGKTLHVGGATGRIHGATESLVDYNRAGIPLVEIVTKPIPGTGALAPVVARAYVTELRDVIRSLGVSDVRMEEGSLRCDVNTSLNLPGAQWGTRTETKNVNSLRSVERAVRSEMLRQASVLDGGGRITQETRHFHEDTGETTSGRSKETATDYRYFPEPDLVPLAPDPDWVAGLKAELPELPRLHRRRLQDRWGLSDLDMQSVVNAGAVELIEQTIAAGASPAGARKWWLGELSRRANETGVELAAVGATPGQVAELQRLVDEGKLNDKLARTVLEGVVAGEGSPAEIMARRGLEVVSDTGALSAAVDEAIAANPDVADKVRAGKVAAAGALVGAVMKTTRGQADARAVRELVLERLGVQG
>NZ_CP022961.1|WP_095564079.1|1458377_1460096_-|metallophosphoesterase
MMDRYDDNDAPETRQRRAVSGARAALATARRWGTVAADGLTAASLGTRRAAASTWGRRTRIALATTVVSLLGVLLGVLLGGRVETDIGPFRAQLALSPSVSGGTTVRIPPLGALQFDSHDGPARLTVQLGALDQRRTEALISDPGNLDRISKLAVHDVSEGAARLVLRTVGAALLSSLLLAALVFRNVRRVAWSGVLSLAITGGSLGLAGLTMHPRALEEPRYEGLLVNAPAVIGDARSIATNYGKYAQQLQRLVGNVSKLYTTLSALPVYEPSPGTTRVLHISDLHLNPSAFQVIQTVVEQFDIDVVIDTGDITDWGSEPEASFVNSIGQLKKPYVYIRGNHDSSDTAAEVAKQPNAIVLDQSITRVAGLTIAGAGDPRFTPDKETSPAGSGLTATVADQVITTGERLADTIRMAAPQKVDIALVHDPASAGPLSGTVPLVLAGHVHHREVLKLPQVPDEQSTQLFVEGSTGGAGLRGLEGEKPTPLSMTVLYFDPGQKLQAYDEITVGGTGQAQVNLERHIITDPKEGDPRASVTPTPTRGPSPTPSAPTGSASPTNPSSTPGSPVPTTG
>NZ_CP022961.1|WP_095564080.1|1460175_1461375_-|PQQ-dependent-sugar-dehydrogenase
MSLRTAYRHGGRTRTAAVLCAAVLFATTGCSFGEPKPDPAGEPPRFPTPSAPPSTQGGGTDQEVVATVLAKGLDVPWAIAFLPDGGALVTERNTANILKIGPESNPDGLKTSTVQQVDGVAASGEGGLLGIAVSPGYEQDQTVFVYYSTARDNRIGRLTLGEQPTPILTGIPRSTVHNGGRLAFGPDGFLYATTGDATERGLAQDPKSLAGKILRITPAGKPAPGNPFPDSPVWSLGHRNVQGLAWDQNKHLYATEFGQDTWDEINRIEPGHNYGWPQVEGGVSASAQPGAEDKFTAPLVQWHTDEASCSGAAIIGRLLAAACLKGERLWLMELTGDGGVLGQPRALLTNRYGRLRAAAAAPDGSLWISTSNKDGRGRPSADDDRLIRLVFSDGGAGRS
>NZ_CP022961.1|WP_095564081.1|1461502_1462054_+|hypothetical-protein
MRDRRWDGPGFRHEPPAADDAAGWITGAVPDGWFTGAPRVVVDREEIAIVGRLPEPELPTDATPADRAAAEAGRINQYREETRDRRIAIARQVEHRYRRKVAWGVACGETEELFTNLSAPVMTRLRQPERQVLDTLVDAGVARSRSEALAWCVRLVGEHAEQWLGELRTAMGTVEELRRRGPA
>NZ_CP022961.1|WP_095567624.1|1462129_1463056_+|2-hydroxyacid-dehydrogenase
MKIWIPHEEGRSLLAGLPGDVRLEVVADPKRAPDDRDGVEFWVPPFLALGTAVRLAGELPDLRVVQLLSAGADAWTGRLPAGVTLCDARGVHDSSTAEWVLTAILAHLRAFDEFARAQGRHEWANPDFLPTDELAGKRVLIVGAGSIGAAIRSRLAPFEVEITMVARTARPAQGVHGVAELPNLLPLADVVVLIVPLTDRTRGLVDADFLAAMPAGALLVNAARGPVVDTAALVAELTAGRLRAALDVTDPEPLPAGHPLWDLPGLLLTPHVGGAVRGLLPRAYRLVEAQLRRYLAGEPLANQVVDGY
>NZ_CP022961.1|WP_095564082.1|1463049_1463451_-|PH-domain-containing-protein
MRSVDTVRFRPNQTIWLAALVAFFSALPIASVSWYVAPILLVPLAIAVWGWRSGTAADRSGLRLRALFGQHRIPWSEVAELGADPRGRVLATLTDGRVIGLPGVRGSDLPRLVAASGQPLDAATAASAGEPPQ

Crispr_ID: NZ_CP022961_10

• CRISPR_ID: NZ_CP022961_10
• CRISPR_location: 1575230-1575340
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_10

Consensus_repeat	Method
GCCCGGCGGGTCTCGCCTGCCGAGCGGAACACGCCTGCC	CRISPRCasFinder

spacers of NZ_CP022961_10

>10.1|1575269|33|NZ_CP022961|CRISPRCasFinder
GAGCGGAACACGCCTGCCCGGCGGGTCTTGCCT

CRISPR arrays and Neighbor proteins around NZ_CP022961_10

CRISPR arrays

The CRISPR arrays of NZ_CP022961_10

>merge|NZ_CP022961|10|1575230-1575340|CRISPRCasFinder
GCCGCGCGGGTCCCGCCCGCCCGGCGGGTCTCGCCTGCCGAGCGGAACACGCCTGCCCGGCGGGTCTTGCCTGCCGAGCGGAACACGCCTGCCCGGCGGGTCTTGCCTGCC

>NZ_CP022961|10|10|1575230-1575340|CRISPRCasFinder
GCCGCGCGGGTCCCGCCCGCCCGGCGGGTCTCGCCTGCC	GAGCGGAACACGCCTGCCCGGCGGGTCTTGCCT
GCCGAGCGGAACACGCCTGCCCGGCGGGTCTTGCCTGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095564166.1|1575404_1576358_-|tyrosine-recombinase-XerC	unknown	unknown	gnl|CDD|234698
NZ_CP022961.1|WP_095567639.1|1584278_1584836_+|ribosome-recycling-factor	unknown	unknown	gnl|CDD|178850
NZ_CP022961.1|WP_095564169.1|1579147_1579507_-|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NZ_CP022961.1|WP_095564167.1|1576385_1577567_-|DNA-processing-protein-DprA	unknown	unknown	gnl|CDD|376794
NZ_CP022961.1|WP_095564168.1|1577563_1579084_-|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_CP022961.1|WP_095564172.1|1582427_1583255_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_CP022961.1|WP_095564159.1|1568160_1568517_+|50S-ribosomal-protein-L19	unknown	unknown	gnl|CDD|235418
NZ_CP022961.1|WP_095564173.1|1583428_1584193_+|UMP-kinase	unknown	unknown	gnl|CDD|234735
NZ_CP022961.1|WP_095564162.1|1570908_1571721_+|ribonuclease-HII	unknown	unknown	gnl|CDD|234574
NZ_CP022961.1|WP_095564161.1|1569683_1570334_+|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NZ_CP022961.1|WP_095564170.1|1579703_1580759_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095564165.1|1573943_1575107_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|223594
NZ_CP022961.1|WP_095564160.1|1568775_1569687_+|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NZ_CP022961.1|WP_095564164.1|1572056_1573169_-|sulfite-oxidase	unknown	unknown	gnl|CDD|239028
NZ_CP022961.1|WP_095564163.1|1571717_1572041_+|DUF2469-domain-containing-protein	unknown	unknown	gnl|CDD|313765
NZ_CP022961.1|WP_095567637.1|1570375_1570915_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240041
NZ_CP022961.1|WP_095567636.1|1567267_1568041_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl|CDD|234581
NZ_CP022961.1|WP_095564171.1|1581355_1582312_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_CP022961.1|WP_095564174.1|1585056_1585449_+|hypothetical-protein	unknown	unknown	gnl|CDD|226318
NZ_CP022961.1|WP_095567638.1|1573344_1573926_+|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095564166.1|1575404_1576358_-|tyrosine-recombinase-XerC	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	2.47353e-123
NZ_CP022961.1|WP_095567639.1|1584278_1584836_+|ribosome-recycling-factor	gnl|CDD|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	1.94238e-99
NZ_CP022961.1|WP_095564169.1|1579147_1579507_-|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	7.59417e-40
NZ_CP022961.1|WP_095564167.1|1576385_1577567_-|DNA-processing-protein-DprA	gnl|CDD|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	2.52411e-73
NZ_CP022961.1|WP_095564168.1|1577563_1579084_-|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	3.08205e-180
NZ_CP022961.1|WP_095564172.1|1582427_1583255_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.26974e-129
NZ_CP022961.1|WP_095564159.1|1568160_1568517_+|50S-ribosomal-protein-L19	gnl|CDD|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	6.3006e-66
NZ_CP022961.1|WP_095564173.1|1583428_1584193_+|UMP-kinase	gnl|CDD|234735	PRK00358, pyrH, uridylate kinase; Provisional.	5.89023e-129
NZ_CP022961.1|WP_095564162.1|1570908_1571721_+|ribonuclease-HII	gnl|CDD|234574	PRK00015, rnhB, ribonuclease HII; Validated.	1.77153e-89
NZ_CP022961.1|WP_095564161.1|1569683_1570334_+|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.69836e-41
NZ_CP022961.1|WP_095564165.1|1573943_1575107_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	7.29417e-41
NZ_CP022961.1|WP_095564160.1|1568775_1569687_+|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.46627e-43
NZ_CP022961.1|WP_095564164.1|1572056_1573169_-|sulfite-oxidase	gnl|CDD|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	1.1263e-109
NZ_CP022961.1|WP_095564163.1|1571717_1572041_+|DUF2469-domain-containing-protein	gnl|CDD|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	6.43115e-63
NZ_CP022961.1|WP_095567637.1|1570375_1570915_+|NUDIX-domain-containing-protein	gnl|CDD|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.46167e-46
NZ_CP022961.1|WP_095567636.1|1567267_1568041_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl|CDD|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	8.60254e-132
NZ_CP022961.1|WP_095564171.1|1581355_1582312_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	5.91474e-159
NZ_CP022961.1|WP_095564174.1|1585056_1585449_+|hypothetical-protein	gnl|CDD|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	5.15308e-15
NZ_CP022961.1|WP_095567638.1|1573344_1573926_+|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	6.12437e-19

Protein sequences

>NZ_CP022961.1|WP_095564165.1|1573943_1575107_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPGARLLFSLDPAVAHLNHGSFGAVPLGVQRVQQRLRDEMEANPLRFFARGLADRIEYTRRHLATFLGAEPDGAALVGNATLGTALVLQSLDLRAGDEIVLTDHGYGAVRLAVERETRRTGAVLRTLAIPLGATDDELVAIVRSGLRPGRTRLLITDQLSSATVRLFPAAAIAAAARDQGVPVLVDAAHVPGMLPVAVRDIGADFWVGNLHKWALAPRGTALLAVAPRWRSRIEPLAVSWEQASGFPLNVEYQSTLDYTPWLAAPTGLFTLRTLGLDAVRGHNEALAVYGQQVIGAALGLDPGDLPQPGGPAVAMRVLPLPPGLAGTVEEARALRQRIADELSAEVAMNARNGRGYLRISAQVYNRAEEYEQLAERLPALLARSGPR
>NZ_CP022961.1|WP_095567638.1|1573344_1573926_+|M23-family-metallopeptidase
MGSGLLAAAATLLALVGAAPPVGPVAPAGVPGAAVGVRGAAVGVPAAGRRLVPEATGAAGFRWPVDGAPLVTRRFDPPPRPWQPGHRGVDLAVAPGAVIRSAGPGTVAFAGQVAGRPVLTVRHGDGLRTTYEPVDPLVRPGDDVPAGAPIGRLRPGHPGCARAACLHWGLRRGDTYLDPLSLLGLGRVRLLPT
>NZ_CP022961.1|WP_095564164.1|1572056_1573169_-|sulfite-oxidase
MNEVSAPARVADPGEGISAEELRLAGRNHALPLEALRYDVTPAGLHYLLIHYDIPDLDPAGHRLVLDGRVERPLTLDLADLRDRPRVTHRVTMECAGNGRALLDPRPVSQPWLVEAVGTAEWTGTPLAPLLREAGLAADAVDVVFTGADHGVERGIEQDYRRALPLAAAVEDGPLLAYEMNGAPLLPQHGAPLRLVVPGWYGMASVKWLTRITVLNREFDGYQNAVAYRLRQRPDEAGVPVTRIEPRALVRPPGFPDFMSRGRVLRPGPCTVDGRAWSGHAPVVRVEVTTDGGATWSPAELEPAPAGPWAWRRWRYAWTARPGRYVLSARAVDASGRTQPVEQAWNRGGFANNLVQRVNVAVLPEPEPGD
>NZ_CP022961.1|WP_095564163.1|1571717_1572041_+|DUF2469-domain-containing-protein
MSAEDLEKYETEMELQLYREYRDIVRQFSYVVETERRFYLANQVDLHVRNSDGEVYFEVEMHDAWVWDMYRPARFVKNVRVMTFKDVNVEELEKPDISLPTDSGFGN
>NZ_CP022961.1|WP_095564162.1|1570908_1571721_+|ribonuclease-HII
MLTPPRTVVRREAGLYALEQALQRRGFRHVAGADEAGRGACAGPLVAAAAILPAGRRGEIEGLADSKLLTSAARERVYDLVVQRALAYAVVVVPAEEVDGRGLHVCNVSALRRALASLSTRPDYVLTDGFRVDGLGTPGLAVWKGDRVAACVAAASVLAKVTRDRIMVELDASFPDYGFAEHKGYVTAEHSAALDRHGPCVEHRFSYVNVAAVSGRSARPPRSRRPLPERPDEAVERGGSPRGTVGVALGDQPRPPVSVGEDVAMEGGVG
>NZ_CP022961.1|WP_095567637.1|1570375_1570915_+|NUDIX-domain-containing-protein
MTTFIDRRAARVLLVDDVGRILLLHGSDPGRAGFDYWFTPGGGLEPGESMAAAAVRELAEETGLRLAPDELGEPVWREVTEFPFDGRWYRQEQEFFLARVPSWTPDTAGFDEIERMSIDALRWWTPAELTGTTERIYPAELAAVLGSAVDGLAVDGGPAVDGGPVVDGRAVAAGGGEAC
>NZ_CP022961.1|WP_095564161.1|1569683_1570334_+|signal-peptidase-I
MIDEQTDKPKPRSSFWKELPILLGVAILVAVLVRAFVLQTFYIPSQSMEHTLDVNDRVLVNKLVYDFRSPHRGEVIVFEAPPDWRNTPEGEDFIKRVIGVGGDHIVCCDTQRRITVNGHPLDEPYIFANVDGQHDPAADEDFDVTVPAGRLWVMGDHRSQSGDSLEHWEQSQGDIQAATITEDSVVGRAFTVFWPFSRAKWLSVPSTFDSVPGPTG
>NZ_CP022961.1|WP_095564160.1|1568775_1569687_+|signal-peptidase-I
MPMWQEIPLLLVVAFCLAVLIRTFLLQAFFIPSGSMEQTLLIGDRVLVNKIVYDVRDPVRGEVVVFRGTDNWAPEAASEPTPGFLGRLGRTLGDLVGVSRPGEKDFIKRVIALPGDKVACCDADGRVTVNGHSLDESAYLWQDSPLDLPANPQECRSRQFDEVVVPPGQLFVMGDHRLVSQDARCQGPVPIANVIGRAFIIIWPHERWATLPVPATFADVPDAQAAAAFGPVPVAGTAPPAGTQPPGGADPVAGTAPAAGVPPVDPGGRTGALTPIVLSLLLTTVFGARARQRPTTRPRRLFP
>NZ_CP022961.1|WP_095564159.1|1568160_1568517_+|50S-ribosomal-protein-L19
MNTLDALDAQSQRTDLPDFRAGDTVKVHARVVEGNRSRVQIFQGVVIRRQGSGLRETFSVRKVSFGVGVERTYPINSPAIDRVEVVTRGDVRRAKLYYLRELRGKKAKIKEKREKQPS
>NZ_CP022961.1|WP_095567636.1|1567267_1568041_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MRVDIVTIFPDYLAPLELSLIGRARATGLLEVAVHDLRRWTHDVHRTVDDTPYGGGPGMVMRPEPWGEALDELAPAGAPPPRLLVPGPGGVRFGQDLAYELATEAHLLFACGRYEGIDQRVLDHAATRMPVTEISLGDYVLFGGEVAVLVVLEAVTRLLPGVLGNASSLDEESHAHGLLEAPVYTKPPSWRALDVPEILRSGDHGRIARWRRTSGLLRTAARRPDLLAALDPAELDKHDVTALREAGFQVPGSDVAE
>NZ_CP022961.1|WP_095564166.1|1575404_1576358_-|tyrosine-recombinase-XerC
MTRRSTRTLHEALPSAMREAVDEFARQLSRVDNRSGHTIRAYVGDVVSLLDHAVRMGCGSPGELDLAVLRSWLARLRTTGAARTSLARRAAAARTFTGWAHRAGLLGCDVGASLASPRAHRELPTVLRADQADRLVETPDGTGTPDPEHAPVLLRDRLMLELLYATGVRISELCGLDTADVDQGRRVVRVLGKGNRERSVPYGVPAQRALDGWLRLGRPVLAGPESGDALLLGARGGRLQPTVARRTVGAYAAAAGLPKTTPHGLRHSAATHLLEGGADLRAVQELLGHSSLSSTQIYTHVSVDRLRAAYRQAHPRA
>NZ_CP022961.1|WP_095564167.1|1576385_1577567_-|DNA-processing-protein-DprA
MTPTALARIALGWLAEPGTWTVYWLVRRHGPLAALERLLAGEVADPALRASVAARLAAGDPRAAAEAAAEHTVRLGARLVTPEDPDWPPRLADLERLWGRPAQRRVDRELAPPLCLWLRGGWPLHDVLDRSVAVVGSRAATPYGSHVAAEIGCGLAERGWTVVSGGAFGIDADAHRGALGAGGPTVAVLACGVDRPYPVGNTALFDRIAEGGLLVSEWPPGAAPLRPRFLTRNRVIAAATVGSVLVEAAARSGATQTLGRALALGRTAMVVPGPVTSAMSVGAHELLRKYPESRLVAGVPHILEEVGRIGEDLAPVPRGPDDPRDRLDDEAALLLEAVPLRGALDVEQLAARAGVDLRTVLRKVPLLEDLGLLVRTDAGYALAPRRPRRADLT
>NZ_CP022961.1|WP_095564168.1|1577563_1579084_-|YifB-family-Mg-chelatase-like-AAA-ATPase
MSYAKVLCVGLVGVTGQLVEVEADLAPGLPAVVLSGLPDTALHEARDRVRAAIVNSGQRWPNRRITVNLLPATLPKHGSAFDLAIAAAMLGGSGELPLAPLDGVVVLGELGLDGSVRPVRGTLPMVAAAARAGVRGVIVPAANAAEAAVVPGVRVRSVDALHRLVAFIRNGEVLPEPPAERPPDPASGPDLADVAGQQLGRRAVEVAAAGGHHLALFGPPGAGKTMLAERLPSILPPLDDAAALEVTSLHSIAGLLPPGIGLIRRPPFQAPHHTTTIAALVGGGSGLARPGALSLAHRGVLFLDEAPELGRGALEALRQPLEDGRVVLRRSQAATEYPARVQLVVAGNPCPCARPAGDAYCECSPLVRRRYLGRLSGPLLDRIDVRVMLKPLRAAELLDPDRLPESSAQVGARVARARDAARERWAPIGRQVNAEVPGATLRRPPWRLPIRDLGSLQRRLDSGSLSARGFDRVIRLAWSIADLDGRGRPGRDDIEEATAMRTGELP
>NZ_CP022961.1|WP_095564169.1|1579147_1579507_-|YraN-family-protein
MTMTRLAVGAYGERCAVRHLIEAEMRVVARNWRCDQGEIDIIAWERDVLAFCEVKSRRGGAYGWPGEAVTAAKVRRLRRLALRWLRESGTHPREIRFDVLEVYVARTGGALVEHIRAAF
>NZ_CP022961.1|WP_095564170.1|1579703_1580759_+|hypothetical-protein
MDGQRDFPAEQEPGWYVEERGYGEERGYGDDRDRGYGGRRRAAQDRHPTDGDLPQQRTDGTGTGYLGDYGDRRPVDRTDSARYDTGGGFGSSTPTSGSGFDPLGSTDGGFGSTGAGAAAATGGTLGNAVGGQTRSNYGRAAEFPVVAPGRTGEPDDERRTGQPGVPDGGGQLGVDGSTGGTGQIPAVGDGSEADSKFATRAIDVRDLRRNASGPDQSRAAESPGAVGGQPGGGFGAGPAAPGVYGGGAPSEGVYRSRRPLRAVLLGLLTVVFELAALRVLLSGVTADPVGVSAVVSGLLLVIGLPALAAGLYGISTGSAALADSGRSWLRPPTGYLVTGLVLLLAAALAAR
>NZ_CP022961.1|WP_095564171.1|1581355_1582312_+|30S-ribosomal-protein-S2
MAIVTMRQMLESGVHFGHQTRRWNPKMKRFILTERNGIYIIDLRQTLDYIEKTYDFVRNTVAEGGSILFVGTKKQAQEAISEQATRVGQPYVNHRWLGGMLTNFQTIYKRLQRMKELEALGDLSVAAQGYTKKETLQLSREKEKLTRTLGGLRDMQKLPAAIWVVDTKKEHIAVDEARKLGIPVIAVLDTNCDPDEVDFPIPGNDDAIRSAELLTKVIASAVGDGLIARSGKSRGGDDKPEPGVVAADEPLAEWERELIEDNEKKAAQTEAAAPAPTEAAAPAPTEAPAPTEAPAPTEAPAPTEAPAQAEAPAPAAAE
>NZ_CP022961.1|WP_095564172.1|1582427_1583255_+|elongation-factor-Ts
MSNFTAADVKRLRDLTGAGMMDCKKALTEAEGDFDKAVELLRIKGAKDVGKRAGRTAANGLIAHSGKALLELNCETDFVAKNADFVAFAQRLVEHGAQAGVTDAEGLLASMLDGRTVADTVQEQSAKIGEKLVLNRFAVLDGTVAVYLHRKAQDLPPQVGVMVEYTGKTDEAADADARGVAMQIAAMRPKFVSRDEVPAETVESERRIAEQTAREEGKPEAALSKIVEGRVNSFFKDFVLLEQSSVADNKKSVKQVLAEAGIEVTRFVRFEVGQA
>NZ_CP022961.1|WP_095564173.1|1583428_1584193_+|UMP-kinase
MTQTVGDTRVENDPTMPPTGRSRRVVLKLSGEVFGGGAVGVDPDVVQAIARQIATAARRGVQVAAVVGGGNFFRGVELQKRGMDRARADYMGMLGTVMNCLALQDFLEKEGIETRVQSAITMAQVAEPYIPLRAIRHLDKGRVVIFGAGAGMPYFSTDTVAAQRALEIHADVVLMSKNGVDGVYTADPRTDPDARKLDSITFSEALRRGLRVADAAAFSLCEENKLPMLVFGAEGTDTIARAVGGERIGTLITA
>NZ_CP022961.1|WP_095567639.1|1584278_1584836_+|ribosome-recycling-factor
MIDDTLLEAEEKMERAVEHAKEEFGAIRTGRATPAMFSKIVLDYYGSPTPLTQMASIAVPEPRMAIIKPYDASQMNAMEKAIRDSDLGVNPNNEGTQLRILLPQMTEERRRDMIKVARHKGEEAKVAIRNVRRRAKEELDRIVKDGEAGEDDGRRAEKELDDLTHRYVSNVDDLIKHKETELLEV
>NZ_CP022961.1|WP_095564174.1|1585056_1585449_+|hypothetical-protein
MKYVILIHSNPQPWGHPTADFLPESKALPRAERERLNKDFEGALAQLMERGEFVHAEALGAPSTARLFRWRDGDRVVTDGPFAEGKEHFAGFFLIDVESQARAEEVARLFSGPGETVELRPTMTDGADTP

Crispr_ID: NZ_CP022961_11

• CRISPR_ID: NZ_CP022961_11
• CRISPR_location: 1803171-1803276
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_11

Consensus_repeat	Method
CCGGCATGAGCGAGCGCAGCGAGCGA	CRISPRCasFinder

spacers of NZ_CP022961_11

>11.1|1803197|54|NZ_CP022961|CRISPRCasFinder
ATCATCCAGTACGGGGCGAAGGAGCCTCATGCCGGTACGCAGCGCAGCGGAGAA

CRISPR arrays and Neighbor proteins around NZ_CP022961_11

CRISPR arrays

The CRISPR arrays of NZ_CP022961_11

>merge|NZ_CP022961|11|1803171-1803276|CRISPRCasFinder
CCGGCATGAGCGAGCGCAGCGAGCGAATCATCCAGTACGGGGCGAAGGAGCCTCATGCCGGTACGCAGCGCAGCGGAGAACCGGCATGAGCGAGCGCAGCGAGCGA

>NZ_CP022961|11|11|1803171-1803276|CRISPRCasFinder
CCGGCATGAGCGAGCGCAGCGAGCGA	ATCATCCAGTACGGGGCGAAGGAGCCTCATGCCGGTACGCAGCGCAGCGGAGAA
CCGGCATGAGCGAGCGCAGCGAGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095564319.1|1798341_1798575_-|hypothetical-protein	unknown	unknown	gnl|CDD|377016
NZ_CP022961.1|WP_095564315.1|1794257_1794836_+|Fe-S-cluster-assembly-protein-HesB	unknown	unknown	gnl|CDD|132296
NZ_CP022961.1|WP_095564322.1|1801726_1802257_-|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|379163
NZ_CP022961.1|WP_095564325.1|1804125_1804752_-|DUF3093-domain-containing-protein	unknown	unknown	gnl|CDD|378627
NZ_CP022961.1|WP_095564331.1|1811169_1812384_+|class-I-SAM-dependent-RNA-methyltransferase	unknown	unknown	gnl|CDD|225174
NZ_CP022961.1|WP_095564329.1|1807441_1808113_-|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl|CDD|223643
NZ_CP022961.1|WP_095564333.1|1815941_1817114_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095564320.1|1798812_1800456_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|235640
NZ_CP022961.1|WP_095567658.1|1812392_1813661_+|anhydro-N-acetylmuramic-acid-kinase	unknown	unknown	gnl|CDD|236579
NZ_CP022961.1|WP_095564326.1|1804821_1805331_+|dUTP-diphosphatase	unknown	unknown	gnl|CDD|234802
NZ_CP022961.1|WP_095564321.1|1800748_1801627_+|inositol-monophosphatase	unknown	unknown	gnl|CDD|238817
NZ_CP022961.1|WP_095564330.1|1808115_1808781_-|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl|CDD|223643
NZ_CP022961.1|WP_095564317.1|1795670_1796315_+|hypothetical-protein	unknown	unknown	gnl|CDD|225415
NZ_CP022961.1|WP_095564328.1|1806613_1807330_+|DUF3159-domain-containing-protein	unknown	unknown	gnl|CDD|371490
NZ_CP022961.1|WP_095564323.1|1802669_1802966_+|DUF4193-domain-containing-protein	unknown	unknown	gnl|CDD|379391
NZ_CP022961.1|WP_095564332.1|1813790_1815785_+|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl|CDD|235470
NZ_CP022961.1|WP_095564318.1|1796494_1798222_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223989
NZ_CP022961.1|WP_095564316.1|1795375_1795660_+|DUF3039-domain-containing-protein	unknown	unknown	gnl|CDD|378609
NZ_CP022961.1|WP_095564327.1|1806192_1806573_+|OB-fold-nucleic-acid-binding-domain-containing-protein	unknown	unknown	gnl|CDD|239934
NZ_CP022961.1|WP_095567657.1|1794918_1795281_+|DUF3099-domain-containing-protein	unknown	unknown	gnl|CDD|378630

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095564319.1|1798341_1798575_-|hypothetical-protein	gnl|CDD|377016	pfam03315, SDH_beta, Serine dehydratase beta chain. L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.	0.00869212
NZ_CP022961.1|WP_095564315.1|1794257_1794836_+|Fe-S-cluster-assembly-protein-HesB	gnl|CDD|132296	TIGR03252, TIGR03252, uncharacterized HhH-GPD family protein. This model describes a small, well-conserved bacterial protein family. Its sequence largely consists of a domain, HhH-GPD, found in a variety of related base excision DNA repair enzymes (see pfam00730). [DNA metabolism, DNA replication, recombination, and repair].	6.77515e-73
NZ_CP022961.1|WP_095564322.1|1801726_1802257_-|LytR-C-terminal-domain-containing-protein	gnl|CDD|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	3.25678e-08
NZ_CP022961.1|WP_095564325.1|1804125_1804752_-|DUF3093-domain-containing-protein	gnl|CDD|378627	pfam11292, DUF3093, Protein of unknown function (DUF3093). This family of proteins with unknown function appears to be restricted to Actinobacteria. Some members are annotated as alanine rich membrane proteins however this cannot be confirmed.	8.84544e-42
NZ_CP022961.1|WP_095564331.1|1811169_1812384_+|class-I-SAM-dependent-RNA-methyltransferase	gnl|CDD|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	4.84811e-92
NZ_CP022961.1|WP_095564329.1|1807441_1808113_-|TrkA-family-potassium-uptake-protein	gnl|CDD|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	5.54069e-45
NZ_CP022961.1|WP_095564320.1|1798812_1800456_-|RNA-polymerase-sigma-factor	gnl|CDD|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	0
NZ_CP022961.1|WP_095567658.1|1812392_1813661_+|anhydro-N-acetylmuramic-acid-kinase	gnl|CDD|236579	PRK09585, anmK, anhydro-N-acetylmuramic acid kinase; Reviewed.	8.90915e-141
NZ_CP022961.1|WP_095564326.1|1804821_1805331_+|dUTP-diphosphatase	gnl|CDD|234802	PRK00601, dut, dUTP diphosphatase.	8.60233e-71
NZ_CP022961.1|WP_095564321.1|1800748_1801627_+|inositol-monophosphatase	gnl|CDD|238817	cd01639, IMPase, IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling. IMPase is one of the proposed targets of Li+ therapy in manic-depressive illness. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria.	5.28089e-87
NZ_CP022961.1|WP_095564330.1|1808115_1808781_-|TrkA-family-potassium-uptake-protein	gnl|CDD|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	1.36165e-41
NZ_CP022961.1|WP_095564317.1|1795670_1796315_+|hypothetical-protein	gnl|CDD|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	3.66654e-46
NZ_CP022961.1|WP_095564328.1|1806613_1807330_+|DUF3159-domain-containing-protein	gnl|CDD|371490	pfam11361, DUF3159, Protein of unknown function (DUF3159). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.	5.16647e-58
NZ_CP022961.1|WP_095564323.1|1802669_1802966_+|DUF4193-domain-containing-protein	gnl|CDD|379391	pfam13834, DUF4193, Domain of unknown function (DUF4193). This domain of unknown function contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.	1.88372e-52
NZ_CP022961.1|WP_095564332.1|1813790_1815785_+|1-deoxy-D-xylulose-5-phosphate-synthase	gnl|CDD|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NZ_CP022961.1|WP_095564318.1|1796494_1798222_+|DEAD/DEAH-box-helicase	gnl|CDD|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	7.85424e-60
NZ_CP022961.1|WP_095564316.1|1795375_1795660_+|DUF3039-domain-containing-protein	gnl|CDD|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.03913e-31
NZ_CP022961.1|WP_095564327.1|1806192_1806573_+|OB-fold-nucleic-acid-binding-domain-containing-protein	gnl|CDD|239934	cd04488, RecG_wedge_OBF, RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-stranded (Holliday) junction in vivo and in vitro. This interconversion provides a route to repair stalled forks. The RecG monomer contains three domains. The N-terminal domain is named for its wedge structure, and may provide the specificity of RecG for binding branched-DNA structures. During the reversal of fork to Holliday junction, the wedge domain is fixed at the junction of the fork where the leading and lagging strand duplex arms meet, and is thought to promote the unwinding of the nascent leading and lagging strands. In order to form the Holliday junction, these nascent strands would be annealed, and the parental strands reannealed. The wedge domain may also be a processivity factor of RecG on these branched chain substrates.	1.16464e-10
NZ_CP022961.1|WP_095567657.1|1794918_1795281_+|DUF3099-domain-containing-protein	gnl|CDD|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.25303e-22

Protein sequences

>NZ_CP022961.1|WP_095564323.1|1802669_1802966_+|DUF4193-domain-containing-protein
MATDYDAPRRDEVDLGEDSLEELKARRVDSQSGAVDVDEAEVAESFELPGADLADEELTVKVLPMQQDEFRCARCFLVHHRSQLATQRNGDLICRECV
>NZ_CP022961.1|WP_095564322.1|1801726_1802257_-|LytR-C-terminal-domain-containing-protein
MSFARVRALVVVGALMILALIFVVVALVRDTQAGQSLATGCQDGEVPANVELPDNKDVKINVYNGTQTAGLAEIVGTDFANRKFQVAKKANDPLHKKIEGVAVLRYGPKGLGSAHLLRAYFLDEADTEFDRDRKDAVVDVVIGERFQQLATTTEVNQAVAALGAPSLPPGTCLGNG
>NZ_CP022961.1|WP_095564321.1|1800748_1801627_+|inositol-monophosphatase
MPDGRPTPQELLEIAVTVARQAAATARRMRAEGVAEVATKSTATDVVTAADRAVERQVVESIRRLRPRDRVLGEEFGPAGGGEAPAAGEEPTGGGRPAAAPAGGPGAVRWIVDPIDGTVNYLYGLPHYAVSLAAEVDGEVVAGVVRNAATEDEWTATRGGGAYRAGRRLRGSTETDLAQSLVATGFGYDPVRRAHQGRVLARLIDQVRDIRRFGAAALDLCLAAEGMVDAYFERGLQPWDLAAGGLVAREAGLRVAGLSGAPAGPDLVIAAPPAIFKPLHDRLVRLDAAGGP
>NZ_CP022961.1|WP_095564320.1|1798812_1800456_-|RNA-polymerase-sigma-factor
MTDPRQTGADVRSLTDTLIAHAQNAGGQLTSAELARSVESAEVTPAQAKKILRALSEAGVTVVVDGSASTRRKVAAARSATPASRVTTAKATKKAAPPAPAPKQAPAAEEAPAAARKTAARRAAPAAADGTAGGTVTATAEAAAKPKAARPAKQATGAKATKAAAKTAKGGKPGEAPAGGEGEVDPEELAAEIEDVVVDEPAELTQAAEADAADAATDNDFEWDDEESEALKQARRDAELTASADSVRAYLKQIGKVPLLNAEQEVELAKRIEAGLYAAERLRAAEDGEEKMVRDMVRDLLWISRDGERAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFSLLQDQLQQVLQTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
>NZ_CP022961.1|WP_095564319.1|1798341_1798575_-|hypothetical-protein
MTPTLTPPPETVAPPAADERCDRCNAAGKLRITLAGGGELVFCGHHANKYAEDLVKITVRFATDPEFTWRGAEMMAN
>NZ_CP022961.1|WP_095564318.1|1796494_1798222_+|DEAD/DEAH-box-helicase
MGAGQVSTETFPALRSWQRKALVQYLRRRSPDFTAVATPGAGKTTFALRIAAELLADGTVQAVTVVAPTEHLKTQWSLAAARVGIQLDDAFRNSDLRSSADFHGAVVTYAQVGMAPQVHRRRTMTRRTLVILDEIHHAGDSRTWGDGVKAAFEPAVRRLMLTGTPFRSDENPIPFVEYERGSDGLLRSRADSVYGYADALREGVVRPVMFLAYSGETRWRTRAGDELAARLGEPMTKDLVGQAWRTALDPAGEWMPQVLRAADARLQAKRAGGMADAAGLVIASDQQAARAYAKLIDRLTGQRPVVVLSDDAGSSARIAAFASSDARWLVAVRMVSEGVDIPRLAVGVYATSASTPLYFAQAIGRFVRARRPGETATVFLPSVPHLLGLASEMEAQRDHVLGKPKSDEDGLDDALLERAQRDDQASGELEKQFEALSATAELDQVIFDGASFGTGAQAGTPEEEEYLGLPGLLTADQVTVLLNKRQADQLAAQRRNRANAPAVPEPRAEAAPMSAAQRRVALRRQLNTLVAAHHHRTGLPHGKIHAELRRLCGGPPSAQATIEQLEERIATVQTL
>NZ_CP022961.1|WP_095564317.1|1795670_1796315_+|hypothetical-protein
MHTSTALLVADLTGVAVFAASGASAAVAKRLDLFGVTFVGIVAALGGGIFRDLVIDRVPPLAFADWRYPATAAVAAGVVFWLHPQFSRLRTTVLVLDAAGLGLFAVTGTAAALAAGVPAVGACLIGTLAGIGGGLGRDLLTGEIPVVLRREIYAVAALAGAVTVAAADRLGWAGPVPLVAAALLVFGVRLIALRRRWAAPVATDRPVRPRTPTR
>NZ_CP022961.1|WP_095564316.1|1795375_1795660_+|DUF3039-domain-containing-protein
MGRVTSPAVPETSGTILERPVERPVEHGDHERFSHYAERDKITEAMVLGTPIKALCGKIWVPSRDPSRFPVCPECKEIFEDDNRFYDQKPESGE
>NZ_CP022961.1|WP_095567657.1|1794918_1795281_+|DUF3099-domain-containing-protein
MKHPEHRPILITDASRSPSDQLHSRQVRYVVMMAIRAVCLIVGAVLISAKAPMLWLWLPLCLVGMVLIPWLAVLLANDRPPREEVRLANRLRHRSHRAEAPPAPSLGAQEAPHRTIDAES
>NZ_CP022961.1|WP_095564315.1|1794257_1794836_+|Fe-S-cluster-assembly-protein-HesB
MALSLPIDPAANDLLNRSPLALLLGMVLDQQIPLEKAFSSPYVLAQRLGHEPTAEELAGYDREALVTLFATPPALHRFPKAMAERVQQVCRILVERYGGDPAGLWVDARTGAELLSRIADLPGFGRQKAQIFLALLGKRYDVRPAGWQAAAGGYGEPDAYRSVADITDPDSLARVRSYKQEMKAAAKARGAG
>NZ_CP022961.1|WP_095564325.1|1804125_1804752_-|DUF3093-domain-containing-protein
MWLRRSGAARPHPAGPARRRPASPAATPGQPCGGVRPARPGPARTLGSVAAAHPSPAVRPDNGYAERLALPWWLWLAAAGLTGLLAAEIWLGAGGVRAWLPFAVLPPLAAVALWWLGRIRIAVADGILAVDDARLPVRYVADAIPLDAAGRREVLGVGSDPLAFVVQRPWVGGAVQVVLADPDDPTPYWVVSSRHPVELAAAVLSARG
>NZ_CP022961.1|WP_095564326.1|1804821_1805331_+|dUTP-diphosphatase
MSEFVPVAVQRIDPELPLPAYAHPGDAGADLVAAREVEIPPGGRELVPTGVAIAVPDGYVGLVHPRSGLATRLGVTVLNAPGTVDAGYRGEIMVNLVNHDASSPARILRGDRIAQLVVQRVERARFHVVDELPPSLRGTGGHGSTGGHASLVGQHEARHDREETRGGAR
>NZ_CP022961.1|WP_095564327.1|1806192_1806573_+|OB-fold-nucleic-acid-binding-domain-containing-protein
MATDERRVSVRRLFQRLTASEAEIEAQELRRESARAGGTPAGVCRRGQVVSISGRLRTVVYTPRTNLPTLEADLYDGTDVVTLVWLGRRHISGIEPGRQLVARGRLAVRDDRKVIYNPYYELEPPH
>NZ_CP022961.1|WP_095564328.1|1806613_1807330_+|DUF3159-domain-containing-protein
MSTGRPPIARSDAGATAEEPAAALAGGPAEAPLPSFAEQVADQLGGWRGMVESSVPVLVFVVANVLGPLRPAVIAAVAVAVAIAVVRLVQRRPIRHAVNGLLGVAVGAAIALRTGNARDFYLPGILYGLGVGAALLISAAVRQPVVGWIWSVIAAKGRSDWRDDPRLIRVFVRLTALWGIVWVLKVGAQAALYMADMDTALGVARIVLGYPPYALLLVITVWTVRRVTRAAAPASVEA
>NZ_CP022961.1|WP_095564329.1|1807441_1808113_-|TrkA-family-potassium-uptake-protein
MRIAIAGAGNVGRSIAQELIENGHQVMLIERQPKMLRPERVPDADWVLADACELASLEEADVAGCEVVVAATGDDKVNLVVSLLAKTEFAVGRVVARVNRAENEWLFTDQWGVDVAVSKPRVMAALVEEAVTVGDLVRLMTFRQGQANLVEITLPPAAPYVGHPVRSVPLPRDSALVAILRGKRVLTPSPDDPLEAGDELVFVCTAEVEDEVRGVVLGGAADR
>NZ_CP022961.1|WP_095564330.1|1808115_1808781_-|TrkA-family-potassium-uptake-protein
MHIVIMGCGRVGSTLAHSLEARGHSVAVVDQDADAFRRLGPDFGGTTVTGVGFDRDVLREAGIERADAFAAVSSGDNSNIISARLARETFGVSRVAARIYDQRRAQVYERLGIPTVATVRWTADRMVRHLVPEGDVEIFRDATSTVSIIEVPLHKDWVGHRLHALEEAAGARAAYVIRFGIGTLPTTGTVIQEGDQLFMLVTDDIAPAVTAAAGTSPEGGH
>NZ_CP022961.1|WP_095564331.1|1811169_1812384_+|class-I-SAM-dependent-RNA-methyltransferase
MTVEDAERIVLTVGPPAHGGHCVARYEGQVVFVRHALPGERVVAEVTETHRGFARADAVEIIEAAPARVEPPCPYARPDRCGGCDLQHVAPQAQRDWKTAVLREQLERLGGLDPAELAALDLTVRAVPGGSLGWRSRMRYAVDAADRAGLRKHRSHEVVPVDRCLIAHPAIRDLPVLASTGQRWPDADEVLTVASSAGDVAIRALRPDGARTVRGPETIAEVAAGREWRLPADGFWQVHPAAADTLTATVRDLLRPVAGETAWDLYGGAGLFAGALAGALGARGRVQVVEADPDAVAAARQNLADLSGVEVVHAPVERALRRRRISGPVDLVVLDPPRAGAGRAVTEAVVGSGARAVAYVACDPAAFARDVRTFRTAGWRLAEVRAYDLFPMTQHLECVGLLLP
>NZ_CP022961.1|WP_095567658.1|1812392_1813661_+|anhydro-N-acetylmuramic-acid-kinase
MRIVSLMSGTSYDGIDVAVGDWELVGDTLRLRPVGERSLPYPDGLPDRIAAVLPPAATTIDEVCRLHTALGQAFAAAAEVGVQIAGGRAELVVSPGQTVFHWVADGRARGTLQLGEPAWIAHRTGLPVLSDLRAADIAAGGQGAPLVPAFDALLLAGTGAGNAADAAPGAAAGTAAAPGADRAASGAASWSRAPRAALNLGGIANLTVVAPPAPVLGYDIGPANALIDAATRRCCGQPYDVDGARAAAGRVHPGLLELLLAEPYYAAPAPKSTGKELFSARYLQDRLAALGEPVDGDDVVATVTELTARIVAAACDRHGVAEVFAAGGGVRNPVLMRRLAALGAGRWRLAGTEELGVPAQAREAYAFGLLGWLSWHHLPGALPSVTGARAAAVLGSWTPGTGSGTPRPAPGSTPAPRRIRVC
>NZ_CP022961.1|WP_095564332.1|1813790_1815785_+|1-deoxy-D-xylulose-5-phosphate-synthase
MSDVEDSANRADLLGSVRGPQDVKRMSAERLTVLAAEIRDFLVAKVSRTGGHLGPNLGVVELTLALHRVFDSPRDRFLFDTGHQAYVHKMVTGRQEDFDRLRQRGGLSGYPNQAESEHDLVENCHASTALSYADGLAKAYALRGEQRSVVAVVGDGALTGGMCWEALNNIATARNPLVIVVNDNGRSYAPTIGGLADHLSSLRLNPGYEKVLDVVKDALGSTPLVGRPMYEVLHAVKKGIKDAVAPQAMFEDLGIKYVGPVDGHDIGAMESALRAAKHFGGPVIVHAVTRKGYGYRPAEEDEADCLHSPSSAFDVETGKLLAAPSVKWTHVFRDELIALADERPDVVAITAAMAEPTGVAALARRHPDRVYDVGIAEQHAVTSAAGLALGGLHPVVALYATFLNRAFDQVLLDVALHNLPVTFVLDRAGVTGPDGPSHYGIWDMSILGVVPGLRVAAPRDAATLREELREAVAVDDGPTVVRFPTGSVAADLPAVRRIGSTDGAGPGGAVDVLAESGRTDVLLVAVGAFGQLGVEVANRVAEQGYGVTVVDPRWVRPVPTELVTLAAKHRLVVSIEDGVRAGGIGDALAKAMRDADVRTPLRDLGVPVAWHEFGTRAQILADLRLTAQDVARDITGWVSLLEEPIEPVRVGGGDRSAKGRAAQN
>NZ_CP022961.1|WP_095564333.1|1815941_1817114_-|hypothetical-protein
MVRRAAPWVLALALLSGGCAAAPQPPATVLRAGFDTLDGTLAVWPARGSLADDRSAAASVSRAVSAWRSPAGDRAYLPASGILWLGEADGTRLALVAASVPGNDASWLVQLRGRDGADFSVERAVEYPDPGYLVYSDVLPVPLSDGRRYLTSARVERLTGPDGKLSISDGLSAPVQVPACAPVAITASLRPTESLPDGKRADRMVDLGSGVGAPRYPLVGDDSNTASAALEGLDTCALGTEDGPFGSVERRIAGRDEAGSMPASWPIDRITSRSLGDVTLGIAPPAELDQLSWRTDSGVMTAVVLRPPSGPPSFSAADRFNPLQSYELTVGGTAYVALVWRAAPDSSVSVPSATSRLVDRPGLVIVAKPADRQTFSLVTPDKTYYRSVNE

Crispr_ID: NZ_CP022961_12

• CRISPR_ID: NZ_CP022961_12
• CRISPR_location: 3443609-3443697
• CRISPR_type: Orphan
• Repeat_type: I-E
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_12

Consensus_repeat	Method
CCGCTCCCCGCACACGCGGGGATGATCC	CRISPRCasFinder

spacers of NZ_CP022961_12

>12.1|3443637|33|NZ_CP022961|CRISPRCasFinder
GAGTAGGGGTCTGAACCCGGGGCTCAGCGCCGA

CRISPR arrays and Neighbor proteins around NZ_CP022961_12

CRISPR arrays

The CRISPR arrays of NZ_CP022961_12

>merge|NZ_CP022961|12|3443609-3443697|CRISPRCasFinder
CCGCTCCCCGCACACGCGGGGATGATCCGAGTAGGGGTCTGAACCCGGGGCTCAGCGCCGACCGCTCCCCGCACACGCGGGGTGATCCT

>NZ_CP022961|12|12|3443609-3443697|CRISPRCasFinder
CCGCTCCCCGCACACGCGGGGATGATCC	GAGTAGGGGTCTGAACCCGGGGCTCAGCGCCGA
CCGCTCCCCGCACACGCGGGGTGATCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565404.1|3448690_3449668_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP022961.1|WP_095567864.1|3435377_3435956_+|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl|CDD|378696
NZ_CP022961.1|WP_095565407.1|3452443_3453772_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP022961.1|WP_095565408.1|3453790_3455221_+|glucuronate-isomerase	unknown	unknown	gnl|CDD|235087
NZ_CP022961.1|WP_095565394.1|3432162_3434178_-|TetM/TetW/TetO/TetS-family-tetracycline-resistance-ribosomal-protection-protein	unknown	unknown	gnl|CDD|223556
NZ_CP022961.1|WP_095565400.1|3443840_3444947_-|sugar-kinase	unknown	unknown	gnl|CDD|238571
NZ_CP022961.1|WP_095565393.1|3431350_3431836_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095567863.1|3430653_3431136_-|glutathione-peroxidase	unknown	unknown	gnl|CDD|238207
NZ_CP022961.1|WP_095565395.1|3434329_3435301_-|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NZ_CP022961.1|WP_095565405.1|3449702_3451046_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270303
NZ_CP022961.1|WP_095567865.1|3445566_3445818_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380393
NZ_CP022961.1|WP_095565396.1|3436157_3437312_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	unknown	unknown	gnl|CDD|133031
NZ_CP022961.1|WP_095565402.1|3445852_3447052_-|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP022961.1|WP_095565401.1|3444943_3445588_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl|CDD|235577
NZ_CP022961.1|WP_095565406.1|3451066_3452206_-|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP022961.1|WP_095565397.1|3437447_3438944_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP022961.1|WP_095565399.1|3439543_3442630_-|protein-kinase	unknown	unknown	gnl|CDD|271199
NZ_CP022961.1|WP_095565403.1|3447167_3447776_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565398.1|3438983_3439487_+|SsrA-binding-protein-SmpB	unknown	unknown	gnl|CDD|376590
NZ_CP022961.1|WP_157756770.1|3442654_3442822_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565404.1|3448690_3449668_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.30095e-77
NZ_CP022961.1|WP_095567864.1|3435377_3435956_+|CGNR-zinc-finger-domain-containing-protein	gnl|CDD|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	6.85214e-15
NZ_CP022961.1|WP_095565407.1|3452443_3453772_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.12945e-35
NZ_CP022961.1|WP_095565408.1|3453790_3455221_+|glucuronate-isomerase	gnl|CDD|235087	PRK02925, PRK02925, glucuronate isomerase; Reviewed.	0
NZ_CP022961.1|WP_095565394.1|3432162_3434178_-|TetM/TetW/TetO/TetS-family-tetracycline-resistance-ribosomal-protection-protein	gnl|CDD|223556	COG0480, FusA, Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis].	3.54923e-131
NZ_CP022961.1|WP_095565400.1|3443840_3444947_-|sugar-kinase	gnl|CDD|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	6.43356e-75
NZ_CP022961.1|WP_095567863.1|3430653_3431136_-|glutathione-peroxidase	gnl|CDD|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	1.42719e-79
NZ_CP022961.1|WP_095565395.1|3434329_3435301_-|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.19717e-19
NZ_CP022961.1|WP_095567865.1|3445566_3445818_-|cupin-domain-containing-protein	gnl|CDD|380393	cd06988, cupin_DddK, Dimethylsulfoniopropionate lyase DddK and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to dimethylsulfoniopropionate lyase DddK from marine bacterium Pelagibacter. DddK cleaves dimethylsulfoniopropionate (DMSP), the organic osmolyte and antioxidant produced in marine environments, and yields acrylate and the climate-active gas dimethyl sulfide (DMS). DddK contains a double-stranded beta-helical motif which utilizes various divalent metal ions as cofactors for catalytic activity; however, nickel, an abundant metal ion in marine environments, confers the highest DMSP lyase activity. Also included in this family is Plu4264, a Photorhabdus luminescens manganese-containing cupin shown to have similar metal binding site to TM1287 decarboxylase, but two very different substrate binding pockets. The Plu4264 binding pocket shows a cavity and substrate entry point more than twice as large as and more hydrophobic than TM1287, suggesting that Plu4264 accepts a substrate that is significantly larger than that of TM1287, a putative oxalate decarboxylase. Thus, the function of Plu4264 could be similar to that of TM1287 but with a larger, less charged substrate. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.12765e-12
NZ_CP022961.1|WP_095565396.1|3436157_3437312_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	gnl|CDD|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	1.0168e-74
NZ_CP022961.1|WP_095565402.1|3445852_3447052_-|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.713e-21
NZ_CP022961.1|WP_095565401.1|3444943_3445588_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl|CDD|235577	PRK05718, PRK05718, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	3.85875e-85
NZ_CP022961.1|WP_095565406.1|3451066_3452206_-|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.86259e-93
NZ_CP022961.1|WP_095565399.1|3439543_3442630_-|protein-kinase	gnl|CDD|271199	cd04791, LanC_SerThrkinase, Lanthionine synthetase C-like domain associated with serine/threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown.	1.51901e-36
NZ_CP022961.1|WP_095565405.1|3449702_3451046_-|extracellular-solute-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.39957e-39
NZ_CP022961.1|WP_095565398.1|3438983_3439487_+|SsrA-binding-protein-SmpB	gnl|CDD|376590	pfam01668, SmpB, SmpB protein.	7.97708e-83
NZ_CP022961.1|WP_095565397.1|3437447_3438944_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.72283e-72

Protein sequences

>NZ_CP022961.1|WP_157756770.1|3442654_3442822_-|hypothetical-protein
MTAPLGLEPRDAGPEALEPVVAFDDGPQLERARLRCADCLPRPAATDPSLYATGR
>NZ_CP022961.1|WP_095565399.1|3439543_3442630_-|protein-kinase
MESAELKDRVARAVAMYGGPGYLLRCDATWLTLVPGGAVVLPEYGWKLHVSCRSVAFPALVERLLPLLLAQGCPVRLARSARVLARLNDGYSVPAAVGKAVTIYPEPDRVRELGWSLAELLRGEPAPRVLGERRVDPAAPVYYWYGPIGGPGVHAGLGSGGMLGAGPDGGQAAGAGLVGPGPAGTGLTGPGLIGTALTGGLLERPAGLAGVRCAPPACPIDPFTGERVDLHAVDRLAVLGGYYRVVAGIYESGRGNVYRAIDERDGGTVVVKQARAHVDEHEEAGDVRLRLRNERRVLQALTGMPDVPRFLDHFRHGDDEFLVTTDVGPYNLVDDVAHHGRYLPAGAAPGGGRTLDGLAARLARGVLELHRRGVVARDLTSRNVVIDGDRAALIDFGLAAYAGAYVPGGTAGYAPARQRRHEPPRDTDDLHALGMVLMFAADGLHPVTVDDDLELPRRRALQTIRSRCGGRPTGVFAAIADLVSGDDDTMRTAAARLAGDGTHGHGHGTSAGTGTSAGTGTSAGTDTGTGTGTGTGTGTGTGTGTGGGTGTGTGGGTGTGTGTGGGLRNGTGTGAGPGAEPRRRSGPRSRPEPPDLGPELAAEITDHLVADLLVATGRLLAEPAGADIGIYRGTAGVGLELLQHADRPGVPDALRALLHHTVRAVTRRNPPPGLLAGRTGVDVFLQLARDRGFAGPDHPEPVVPGAGWLPAGDDLMAGAAGVGLGHLLLHRSTGDRAHLAVARRCAESILAGPAPAGRTAADRLPEAAAVEPSAGRARGLAGTAELLLCLAEVTGEPAHRAAAADRVALLAGRAESLVQRAGGPRAASLAVSWCQGLAGMAQVLLYGGSVLADPALSALAGRLGEQCVTLLPRIGVPGQCCGSAGVGNLLVDLALTDGGGPGWDAAATAGRHLLLRAGGSARRPRFGDDADGHGASWAHGLAGTLGFVRRLARRSGPAGLPAPSWAAWLAGPDSPAGPPAAAAGSPAGGADPAAGAAGGRSAYPGGPLPAPPPGWSLRPDAVAACPSG
>NZ_CP022961.1|WP_095565398.1|3438983_3439487_+|SsrA-binding-protein-SmpB
MARETGRKAVASNRKARHEYTILKTYEAGLVLVGTEVKSLRAGYVSLVDAFAQERDGEIMLYGLHIAEYGFGSWTNHQPRRTRKLLLRRVEIDRILEKLREPGLTLVPLSIYFSDGWAKVELGLARGRRTYDKRQAIAERDANREIARELGRRLKGRPGSTRRTSRA
>NZ_CP022961.1|WP_095565397.1|3437447_3438944_+|MFS-transporter
MSVTTSTGSGLPETPVAAGSAHPRRWVALAVIAVAQLMVVLDATIVNIALPQAQASLGISDADRQWVVTAYTLAFGGLLLLGGRIADYWGRKRTFLVGIVGFALASAVGGVAQSGELLFAARALQGAFGALLAPASLALLTVLFTEAHERAKAFAVYGAIAGGGSAVGLVLGGVLTEYANWRWCLLVNVPVALVALVAALPLVPESRAHGNTRYDVPGALVITAGLVTLVYGFTKAAEDGWGATATIALIAAGVVLIAAFVLIELRSSHPLLPLRIVLDRNRGGAFLASMLIGAGLFGAFLFLTFYFQVVLRYSPVKAGLASLPVTAGVLIAATLASQLMPRLGAKPLMLTGAALAASGMLLLTRIGVDTSFPAHLLPAQVVLGLGLGFTFVPLSSLALVGVPEHDAGAASAALNATQQVGGSLGTALLNTMYTSAVTAYLASHLPPDPVTQVRGLVHGYTVAFAWGAGLILLSGVATAVLITVRRRDIPTGNAIHVG
>NZ_CP022961.1|WP_095565396.1|3436157_3437312_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein
MDVVIPVHNEETDLEPCVRRLHDYLATTFPYPFRITIADNASTDATPAVALRLAAELPRVTAVRLAEKGRGRALREVWFRSEAAVLAYMDVDLSTDLAGLLPLVAPLISGHSELAIGTRLARGSRVVRGPKRELISRGYNLLLRGALAVRFSDAQCGFKAIRRDVARRLLPLVRDTGWFFDTELLVLAQRAGMRIHEVPVDWVDDPDSRVDLLDTALTDLRGIVRLVRALAGGALPVAELRRDLGRAPLAPGVPAGLGRQLVRFVTVGVASTLAYLLLYAALRTGLGAQPANLLALLVTAIGNTALNRRLTFGVRGAAGAARQHAQGLLIFALGLVLTSGSLAVLGALLQQPPRLVELTVLTVANLTATLLRFLLLRRWVFRTA
>NZ_CP022961.1|WP_095567864.1|3435377_3435956_+|CGNR-zinc-finger-domain-containing-protein
MLFTHDTECTLSATAALVNTAGGDTGSGTSDTGNTEGLPDVAALDAFVTAHNWTGRHERTEAELHGVRELRPRLRRIWYADEDGVVEIVNGLLRAAAALPQLIKHDDQPYHLHAVPRDAPLPTRMAVEAAMALADLIRAGELDRLRRCAYPGCANVLVDLSRNRSRRFCDAGCGNRAAVSAYRARKAAGRKS
>NZ_CP022961.1|WP_095565395.1|3434329_3435301_-|EamA-family-transporter
MPQQRFAGVGLGLALLSAAAFATSGTFARSLIDAGWSSDAAVATRVGVAALILAGPAAWSLRGRWRTLPRHAGVIGAFGLLAVGAAQGCFFNAVRYLPVGVALLLEYLGIILVVGWTWLVHRQPPRRLTVAGSIAAIAGLALVLNITGGGGIHPAGVFWGLGAAVGLAGYFVLSARTDSDLSPVVLACGGMAVGTVVLLGVGLLGVLPLHATFGTVELGGHRLGWLVPVVGLSLIASVVAYVTGIGAARALGARLSSFVGLTEVLFAVLIAWLALAELPTAGQLLGGVLIVAGVALVRLDELRPARPGPDAAEPAVPDLAVRG
>NZ_CP022961.1|WP_095565394.1|3432162_3434178_-|TetM/TetW/TetO/TetS-family-tetracycline-resistance-ribosomal-protection-protein
MTRTLNLGILAHVDAGKTSLTERLLYAAGAIDAPGSVDDGSTRTDTLALERQRGITIRSAVVSFRVGDVAVNLIDTPGHPDFIAEVERALGVLDGAVLVVSAVEGVQAQTRLLMRTLRRLGVPTLLFVNKIDRAGARPDDLLAGLAEQLSPAVVPLGTVVSAGRREAAYRPYPAAAARPRDRTLDVLADRDDALLAAYVRDPASVTPARLRAALVTQSRRAAVHPVLFGSAITGAGVDALLAALPELLPAAAGDAAGPAAGTVFKVERGPAGEKLAYVRMFAGTLRLRDRVGAAADRPDRVTGIELFDGGTTVRTDALPAGRIGRVRGLSRIRIGDPVGDAVGAAVDGTAGGAAGGHRFAPPSLETVVLPVRAADRAAVHAALGQLAEQDPLINLRQDDVRQEISVSLYGEVQKEVVEATLAAGYGLAVTFRESTTICIERPVHTGAAVEVIGAKDNPFLGTIGLRVEPAPLDSGIEFRLGIEPGALPLAFLRAIEETVRETLGQGLCGWAVTDCRVTLIRSGYWARQSHSHGVFDKSMSSTAGDFRNLTPLVLMAALRRAGTRVYEPMHRFRLDIPADLLGPVLAALSTLEAVPRGSEPHGRTYTIHGVVPAARVHDLERRLPGLTRGEGTLEAAFDHHRQVRGAAPTRTRSDHNPLDRRAYLLHVVRRV
>NZ_CP022961.1|WP_095565393.1|3431350_3431836_-|hypothetical-protein
MNTLILRRTGRTQWTLLDASGPAAGRLRAGRGLASAELTTAAGSWLAHTRDRRRRHVTAGPGGAPGVRLAPREAQLPGSAPVPARWTVRRTPARYVGVLDHPDGRITVRAPALFGGRVRVECTGTRSDLVVLAACFALLTRRHRDRMIMLVVAAATSHGPG
>NZ_CP022961.1|WP_095567863.1|3430653_3431136_-|glutathione-peroxidase
MSLYDIGIASLAGEPDELGRHRGRPTLIVNVASRCGLTPQYAGLERLAQRYPGLTVLGVPCNQFAGQEPGSPEEIAEFCSATYGVTFPLTEKVEVNGSGRHPLYAALIDAPDADGHTGDVRWNFEKFLVDAEGRVAARFAPPVDPESPEVVAAVEKVLAG
>NZ_CP022961.1|WP_095565400.1|3443840_3444947_-|sugar-kinase
MSGTGLTARDRDDCRYDLVSLGEVMLRLDPGEGRIRTARSLRVWEGGGEYNVARGLRRCFGQRTAVVTALADNEVGRLVEDLILTGGVDTALLRWMPYDGIGRGVRNGLNFTERGFGVRGAVGVSDRAASAASQLRPEDVDWEHLFGTLGVRWLHTGGIYAGLAEGTPDVVEAAMSAARRHGTIISYDLNYRPSLWKAVGGQERAREVNRRLVRYVDVLIGNEEDFTAGLGFEVPDTAEDLSTLDAANFRRMLKEVVTAYPHLKVIATTLRTVHTATVNDWGATAWSPEGFVSATHRPGLQILDRVGGGDSFASGLIYGLLELGDLALAVEYGAAHGALAMTTPGDTSMASLAEVEKLVRGGGARVDR
>NZ_CP022961.1|WP_095565401.1|3444943_3445588_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MDAPAAVIAEVLAETGVLPVVVLDDADQAGPLGAALLAGGLRAVEVTFRTAAAEAAIRTLAKEPELLVGAGTVVNPDQVDRAVEAGARFVVSPGFSPAVAGRCAQRGVPLFPGVATGTEIMMALDAGLETVKFFPAERLGGVAMVSALSAPFPSVRFVPTGGIDAANLADYLSIPAVLAVGGTWMVARPLLREGRWDEISALAAAAVRAGGRAG
>NZ_CP022961.1|WP_095567865.1|3445566_3445818_-|cupin-domain-containing-protein
MDRGGFRRYDEPGFRTHNEPGPHTHTVPEVFCIFQGSGTIEINGARADRFTAGDVLLIEPGEDHHLISEGDEPLVFSWMHLLP
>NZ_CP022961.1|WP_095565402.1|3445852_3447052_-|Gfo/Idh/MocA-family-oxidoreductase
MSARVALVGAGGHGRSHRRNLARLAERGLVEPVALCDTNPVEDPGDVPVFTELAAMLAATAPDVVIICTPPHTHLEIALAAVAAGADLLLEKPPVSSLDEHADLLAALDRTGRSCQVGFQALGSAALPGLVSAAAAAVAPSGGDGSAARGHTGGPLLAAGLGAWWRQDAYWRRSPWAGRRRLHGRFVADGALANPFAHALMQSIAVADAATGWPRGPVAVDLEWYRTRDIEVEDTACLRLTDLAGGTVEVAVTLSSDTFVPGEIHAGGAVLEYPTDRLRLPGDPDWRPPAGRVDLLENLLAHRAAGVPLVAPLARTRMFTAMLAVLATAPVPTPVPDRYLRPHPEGAGQVIDGVADLLRAAAERGALPSELGVPWAVPPYRTVLHPSPKESSHAKTDAR
>NZ_CP022961.1|WP_095565403.1|3447167_3447776_-|hypothetical-protein
MTVEATDRRDWRDITRDATDLATLGILLTIAALPLLSAAAAAGTASAALRDWLDTGSWPPAHRTIDRFRRALLPGAGASLVALAGAGLLAADLIGLAGGAVPGGPPVLVLTGAVAALLAGYVGLVVVEVGHTDGRGWRAAATAVARQCADRPARWLAAVGVSSLVLLLGTLVAPVTVPILVGYALAALHAVTRRLSRTEKLQ
>NZ_CP022961.1|WP_095565404.1|3448690_3449668_-|sugar-ABC-transporter-permease
MAVTTAPEQIHRAPRPVRTARKRSGPGAGGEGLAGYVFLSPWLLGLLGITAIPMLLSLYLSFTNYDVLTPWSEVEWVGLANYRRMFTADPAYWHAVRVTVTFALVAVPLKLAAALGVALLLNKAWRGVGLFRGLFYLPSLLGGSVALAIVWRSMFSGDGAVNSFLGLFGIQGQPWVNDPDWALETLMALAIWQFGAPMVIFLAGLKQVPTELYEAAAVDGAGRSRQFFHVTLPMLSPVIFFNLVLETIHGFQGFTAAFVVSRGTGGPVDSTLMYTLKLYVSGFTNLEMGYASAMAWVFLIAVSVITAVFFSTGRFWVHYSDGTNS
>NZ_CP022961.1|WP_095565405.1|3449702_3451046_-|extracellular-solute-binding-protein
MYAEPTTPADPPAANHRTALPRRRLLSLVAATLIAAPLTFGAAACGGDDSSDDPNAPVKISIFWWGGDARAKLTEDALALYTQKHPNVTFEKTWQANKGYFDKLATLVAGGGAPDIFQIDDNYLTEYASRNATLDLTSLQQSGKIDTSKFPESLWKYGVVDGKLAGIASGENTQGLVYDKTLLTKNGLPEPTTGMSWEEHIAWAQQVTAKTGVPGTQDPSADYKAFWVWLRQQGKDLYQGTSLGFTAADVTAWFDLWKGARDKKATPSPDVIHEGNATDVTTQLVVTGKADTSWVWANQLPELKKNTNNELGVVAYPGDPSGQWARASMYYSVFKGSKHKDAAADVIDFLVNDPEAVKILGTDRGLPSNLDLRQQIADSVDDPAMKLSIQFETEMAGKFGQAPQVPLKGHSTIRSELLKAAEEAQFGRSSSAEAAEQFMAACQAAIA
>NZ_CP022961.1|WP_095565406.1|3451066_3452206_-|LacI-family-transcriptional-regulator
MPATIRDVARASGVHISTVSRTFSAPHLVNPDTRSRVLACAESLGYRPNRAARALITGRTHNIGLIIADIANPFFPPLIKAAERQARQRDYHVFVADTNEDPAAEEELVHALAKQVDGVLLCSPRMSNSLIEQLSREVPLVVINRQITGLPTVVMDNGQGARLAVEHLLGLGHRDLALLAGPRGSWTSREIRRAASAAARSGGATLTVIGPNTPTESSGGALAEQVRRCGATAVLAYNDLMAIGLIEGLDAIGMRVPRDVSVVGIDDIALSRLTRPKLTTVATPTAVAGRTAVDMLLQHDAPAGSRGGRAGGRGTAGDDRRTTAQVTLQTELVIRESTGPGPAAATDRPGIRTTAAGPGPHPTADPGTTTATAGTVVAS
>NZ_CP022961.1|WP_095565407.1|3452443_3453772_+|Gfo/Idh/MocA-family-oxidoreductase
MPASSPGRRRYAVVGTGARAEMFVRALVVDHADRAELVAFADVNQARMDAHNRWLTDLGRPAVPTYRAADFAAMLDKERVDTVLVTTVDRTHDEYIVAAVRAGRDVVTEKPMTVDVPRCRRILDAVAETGAQVSVAFNYRYNPLHEAVRATLAAGEIGEIGSVHFEWLLDVRHGADYFRRWHRDRANSGGLLVHKAGHHFDLVNWWLDSVPERVYAEGRLFFYGPAGQRHGYARDYDRVHGSPAAQDDPFALRLAEHPRLRELYLEAEGEDGYHRDQNVFAPGVTIEDDMAVLVRYASGATMSYHLTAYAPWEGYRVMFNGSRGRLELEVAESTHVSPAAAGALKGAALHGAEAAAEEGSATLTLRPYWAPPRQIPVAGRTRSGHGGADARMARVLFGGEADPHGRTATARDGALALLTGLAANQSMATGEAVRVADLLTVA
>NZ_CP022961.1|WP_095565408.1|3453790_3455221_+|glucuronate-isomerase
MPAAPDLLLPAEPNQRAIARDLYALVAERPLISPHGHVDPAILADDTPFPDPAQLLIVPDHYLTRMLLSQGVPPAELGVPSRDGSPVETDGRRIWRRFAEHWYLFRGTPSRLWLERTFRTVFGVDTALSPQTADRVYDEIADRLAEPEFRPRALFERFNIEVLATTESPLDDLGRHAKLAADGWGGPGGRVVTTFRPDNVVDMEFDGWQDNVARLGEVAGTDTMAYEGYLEALRRRREAFIAAGATSSDHGHPTAGTLSLSAREAAQLYERGLRGGADAADAEAFRAHMLLEFARMSLEDGLVLQLHPGAVRNHNRWLYARHGRDTGGDVPQATEYVHALAPLLDAYGNDPRLRVVLYTLDEYTFSRELAPLAGGYAALYLGAPWWFLDSPEVLRRFRESVTESAGFYNTAGFVDDTRAFCSIPVRHEVARRVDAGFLARLVAEHRLPLDEAAETIVDLAYHLPRKVFRLDGEAHR

Crispr_ID: NZ_CP022961_13

• CRISPR_ID: NZ_CP022961_13
• CRISPR_location: 3447077-3447160
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_13

Consensus_repeat	Method
GGGGCTGGCAAACCCGGCCAGCTC	CRISPRCasFinder

spacers of NZ_CP022961_13

>13.1|3447101|36|NZ_CP022961|CRISPRCasFinder
CTCGCGCTCACCGGAACATCTCCGTTCGCGACTGCG

CRISPR arrays and Neighbor proteins around NZ_CP022961_13

CRISPR arrays

The CRISPR arrays of NZ_CP022961_13

>merge|NZ_CP022961|13|3447077-3447160|CRISPRCasFinder
GGGGCTGGCAAACCCGGCCAGCTCCTCGCGCTCACCGGAACATCTCCGTTCGCGACTGCGGGGGCTGGCAGACCCGGCCAGCTC

>NZ_CP022961|13|13|3447077-3447160|CRISPRCasFinder
GGGGCTGGCAAACCCGGCCAGCTC	CTCGCGCTCACCGGAACATCTCCGTTCGCGACTGCG
GGGGCTGGCAGACCCGGCCAGCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565404.1|3448690_3449668_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP022961.1|WP_095567864.1|3435377_3435956_+|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl|CDD|378696
NZ_CP022961.1|WP_095565407.1|3452443_3453772_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP022961.1|WP_095565408.1|3453790_3455221_+|glucuronate-isomerase	unknown	unknown	gnl|CDD|235087
NZ_CP022961.1|WP_095565400.1|3443840_3444947_-|sugar-kinase	unknown	unknown	gnl|CDD|238571
NZ_CP022961.1|WP_095567867.1|3461622_3462060_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565398.1|3438983_3439487_+|SsrA-binding-protein-SmpB	unknown	unknown	gnl|CDD|376590
NZ_CP022961.1|WP_095565409.1|3455217_3456507_+|fuconate-dehydratase	unknown	unknown	gnl|CDD|239440
NZ_CP022961.1|WP_095565396.1|3436157_3437312_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	unknown	unknown	gnl|CDD|133031
NZ_CP022961.1|WP_095565406.1|3451066_3452206_-|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP022961.1|WP_095567866.1|3459908_3461444_+|pectate-lyase	unknown	unknown	gnl|CDD|226384
NZ_CP022961.1|WP_095565405.1|3449702_3451046_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270303
NZ_CP022961.1|WP_095567865.1|3445566_3445818_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380393
NZ_CP022961.1|WP_095565410.1|3458290_3459673_+|pectate-lyase	unknown	unknown	gnl|CDD|214765
NZ_CP022961.1|WP_095565401.1|3444943_3445588_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl|CDD|235577
NZ_CP022961.1|WP_095565397.1|3437447_3438944_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP022961.1|WP_095565399.1|3439543_3442630_-|protein-kinase	unknown	unknown	gnl|CDD|271199
NZ_CP022961.1|WP_095565403.1|3447167_3447776_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565402.1|3445852_3447052_-|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP022961.1|WP_157756770.1|3442654_3442822_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565404.1|3448690_3449668_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.30095e-77
NZ_CP022961.1|WP_095567864.1|3435377_3435956_+|CGNR-zinc-finger-domain-containing-protein	gnl|CDD|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	6.85214e-15
NZ_CP022961.1|WP_095565407.1|3452443_3453772_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.12945e-35
NZ_CP022961.1|WP_095565408.1|3453790_3455221_+|glucuronate-isomerase	gnl|CDD|235087	PRK02925, PRK02925, glucuronate isomerase; Reviewed.	0
NZ_CP022961.1|WP_095565400.1|3443840_3444947_-|sugar-kinase	gnl|CDD|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	6.43356e-75
NZ_CP022961.1|WP_095565397.1|3437447_3438944_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.72283e-72
NZ_CP022961.1|WP_095565409.1|3455217_3456507_+|fuconate-dehydratase	gnl|CDD|239440	cd03324, rTSbeta_L-fuconate_dehydratase, Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism. A member of this family, from Xanthomonas, has been characterized to be a L-fuconate dehydratase. rTS beta belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NZ_CP022961.1|WP_095565396.1|3436157_3437312_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein	gnl|CDD|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	1.0168e-74
NZ_CP022961.1|WP_095565406.1|3451066_3452206_-|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.86259e-93
NZ_CP022961.1|WP_095567866.1|3459908_3461444_+|pectate-lyase	gnl|CDD|226384	COG3866, PelB, Pectate lyase [Carbohydrate transport and metabolism].	7.22762e-65
NZ_CP022961.1|WP_095567865.1|3445566_3445818_-|cupin-domain-containing-protein	gnl|CDD|380393	cd06988, cupin_DddK, Dimethylsulfoniopropionate lyase DddK and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to dimethylsulfoniopropionate lyase DddK from marine bacterium Pelagibacter. DddK cleaves dimethylsulfoniopropionate (DMSP), the organic osmolyte and antioxidant produced in marine environments, and yields acrylate and the climate-active gas dimethyl sulfide (DMS). DddK contains a double-stranded beta-helical motif which utilizes various divalent metal ions as cofactors for catalytic activity; however, nickel, an abundant metal ion in marine environments, confers the highest DMSP lyase activity. Also included in this family is Plu4264, a Photorhabdus luminescens manganese-containing cupin shown to have similar metal binding site to TM1287 decarboxylase, but two very different substrate binding pockets. The Plu4264 binding pocket shows a cavity and substrate entry point more than twice as large as and more hydrophobic than TM1287, suggesting that Plu4264 accepts a substrate that is significantly larger than that of TM1287, a putative oxalate decarboxylase. Thus, the function of Plu4264 could be similar to that of TM1287 but with a larger, less charged substrate. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.12765e-12
NZ_CP022961.1|WP_095565410.1|3458290_3459673_+|pectate-lyase	gnl|CDD|214765	smart00656, Amb_all, Amb_all domain.	5.81892e-49
NZ_CP022961.1|WP_095565401.1|3444943_3445588_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl|CDD|235577	PRK05718, PRK05718, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	3.85875e-85
NZ_CP022961.1|WP_095565402.1|3445852_3447052_-|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.713e-21
NZ_CP022961.1|WP_095565399.1|3439543_3442630_-|protein-kinase	gnl|CDD|271199	cd04791, LanC_SerThrkinase, Lanthionine synthetase C-like domain associated with serine/threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown.	1.51901e-36
NZ_CP022961.1|WP_095565398.1|3438983_3439487_+|SsrA-binding-protein-SmpB	gnl|CDD|376590	pfam01668, SmpB, SmpB protein.	7.97708e-83
NZ_CP022961.1|WP_095565405.1|3449702_3451046_-|extracellular-solute-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.39957e-39

Protein sequences

>NZ_CP022961.1|WP_095565402.1|3445852_3447052_-|Gfo/Idh/MocA-family-oxidoreductase
MSARVALVGAGGHGRSHRRNLARLAERGLVEPVALCDTNPVEDPGDVPVFTELAAMLAATAPDVVIICTPPHTHLEIALAAVAAGADLLLEKPPVSSLDEHADLLAALDRTGRSCQVGFQALGSAALPGLVSAAAAAVAPSGGDGSAARGHTGGPLLAAGLGAWWRQDAYWRRSPWAGRRRLHGRFVADGALANPFAHALMQSIAVADAATGWPRGPVAVDLEWYRTRDIEVEDTACLRLTDLAGGTVEVAVTLSSDTFVPGEIHAGGAVLEYPTDRLRLPGDPDWRPPAGRVDLLENLLAHRAAGVPLVAPLARTRMFTAMLAVLATAPVPTPVPDRYLRPHPEGAGQVIDGVADLLRAAAERGALPSELGVPWAVPPYRTVLHPSPKESSHAKTDAR
>NZ_CP022961.1|WP_095567865.1|3445566_3445818_-|cupin-domain-containing-protein
MDRGGFRRYDEPGFRTHNEPGPHTHTVPEVFCIFQGSGTIEINGARADRFTAGDVLLIEPGEDHHLISEGDEPLVFSWMHLLP
>NZ_CP022961.1|WP_095565401.1|3444943_3445588_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MDAPAAVIAEVLAETGVLPVVVLDDADQAGPLGAALLAGGLRAVEVTFRTAAAEAAIRTLAKEPELLVGAGTVVNPDQVDRAVEAGARFVVSPGFSPAVAGRCAQRGVPLFPGVATGTEIMMALDAGLETVKFFPAERLGGVAMVSALSAPFPSVRFVPTGGIDAANLADYLSIPAVLAVGGTWMVARPLLREGRWDEISALAAAAVRAGGRAG
>NZ_CP022961.1|WP_095565400.1|3443840_3444947_-|sugar-kinase
MSGTGLTARDRDDCRYDLVSLGEVMLRLDPGEGRIRTARSLRVWEGGGEYNVARGLRRCFGQRTAVVTALADNEVGRLVEDLILTGGVDTALLRWMPYDGIGRGVRNGLNFTERGFGVRGAVGVSDRAASAASQLRPEDVDWEHLFGTLGVRWLHTGGIYAGLAEGTPDVVEAAMSAARRHGTIISYDLNYRPSLWKAVGGQERAREVNRRLVRYVDVLIGNEEDFTAGLGFEVPDTAEDLSTLDAANFRRMLKEVVTAYPHLKVIATTLRTVHTATVNDWGATAWSPEGFVSATHRPGLQILDRVGGGDSFASGLIYGLLELGDLALAVEYGAAHGALAMTTPGDTSMASLAEVEKLVRGGGARVDR
>NZ_CP022961.1|WP_157756770.1|3442654_3442822_-|hypothetical-protein
MTAPLGLEPRDAGPEALEPVVAFDDGPQLERARLRCADCLPRPAATDPSLYATGR
>NZ_CP022961.1|WP_095565399.1|3439543_3442630_-|protein-kinase
MESAELKDRVARAVAMYGGPGYLLRCDATWLTLVPGGAVVLPEYGWKLHVSCRSVAFPALVERLLPLLLAQGCPVRLARSARVLARLNDGYSVPAAVGKAVTIYPEPDRVRELGWSLAELLRGEPAPRVLGERRVDPAAPVYYWYGPIGGPGVHAGLGSGGMLGAGPDGGQAAGAGLVGPGPAGTGLTGPGLIGTALTGGLLERPAGLAGVRCAPPACPIDPFTGERVDLHAVDRLAVLGGYYRVVAGIYESGRGNVYRAIDERDGGTVVVKQARAHVDEHEEAGDVRLRLRNERRVLQALTGMPDVPRFLDHFRHGDDEFLVTTDVGPYNLVDDVAHHGRYLPAGAAPGGGRTLDGLAARLARGVLELHRRGVVARDLTSRNVVIDGDRAALIDFGLAAYAGAYVPGGTAGYAPARQRRHEPPRDTDDLHALGMVLMFAADGLHPVTVDDDLELPRRRALQTIRSRCGGRPTGVFAAIADLVSGDDDTMRTAAARLAGDGTHGHGHGTSAGTGTSAGTGTSAGTDTGTGTGTGTGTGTGTGTGTGGGTGTGTGGGTGTGTGTGGGLRNGTGTGAGPGAEPRRRSGPRSRPEPPDLGPELAAEITDHLVADLLVATGRLLAEPAGADIGIYRGTAGVGLELLQHADRPGVPDALRALLHHTVRAVTRRNPPPGLLAGRTGVDVFLQLARDRGFAGPDHPEPVVPGAGWLPAGDDLMAGAAGVGLGHLLLHRSTGDRAHLAVARRCAESILAGPAPAGRTAADRLPEAAAVEPSAGRARGLAGTAELLLCLAEVTGEPAHRAAAADRVALLAGRAESLVQRAGGPRAASLAVSWCQGLAGMAQVLLYGGSVLADPALSALAGRLGEQCVTLLPRIGVPGQCCGSAGVGNLLVDLALTDGGGPGWDAAATAGRHLLLRAGGSARRPRFGDDADGHGASWAHGLAGTLGFVRRLARRSGPAGLPAPSWAAWLAGPDSPAGPPAAAAGSPAGGADPAAGAAGGRSAYPGGPLPAPPPGWSLRPDAVAACPSG
>NZ_CP022961.1|WP_095565398.1|3438983_3439487_+|SsrA-binding-protein-SmpB
MARETGRKAVASNRKARHEYTILKTYEAGLVLVGTEVKSLRAGYVSLVDAFAQERDGEIMLYGLHIAEYGFGSWTNHQPRRTRKLLLRRVEIDRILEKLREPGLTLVPLSIYFSDGWAKVELGLARGRRTYDKRQAIAERDANREIARELGRRLKGRPGSTRRTSRA
>NZ_CP022961.1|WP_095565397.1|3437447_3438944_+|MFS-transporter
MSVTTSTGSGLPETPVAAGSAHPRRWVALAVIAVAQLMVVLDATIVNIALPQAQASLGISDADRQWVVTAYTLAFGGLLLLGGRIADYWGRKRTFLVGIVGFALASAVGGVAQSGELLFAARALQGAFGALLAPASLALLTVLFTEAHERAKAFAVYGAIAGGGSAVGLVLGGVLTEYANWRWCLLVNVPVALVALVAALPLVPESRAHGNTRYDVPGALVITAGLVTLVYGFTKAAEDGWGATATIALIAAGVVLIAAFVLIELRSSHPLLPLRIVLDRNRGGAFLASMLIGAGLFGAFLFLTFYFQVVLRYSPVKAGLASLPVTAGVLIAATLASQLMPRLGAKPLMLTGAALAASGMLLLTRIGVDTSFPAHLLPAQVVLGLGLGFTFVPLSSLALVGVPEHDAGAASAALNATQQVGGSLGTALLNTMYTSAVTAYLASHLPPDPVTQVRGLVHGYTVAFAWGAGLILLSGVATAVLITVRRRDIPTGNAIHVG
>NZ_CP022961.1|WP_095565396.1|3436157_3437312_+|bifunctional-glycosyltransferase-family-2/GtrA-family-protein
MDVVIPVHNEETDLEPCVRRLHDYLATTFPYPFRITIADNASTDATPAVALRLAAELPRVTAVRLAEKGRGRALREVWFRSEAAVLAYMDVDLSTDLAGLLPLVAPLISGHSELAIGTRLARGSRVVRGPKRELISRGYNLLLRGALAVRFSDAQCGFKAIRRDVARRLLPLVRDTGWFFDTELLVLAQRAGMRIHEVPVDWVDDPDSRVDLLDTALTDLRGIVRLVRALAGGALPVAELRRDLGRAPLAPGVPAGLGRQLVRFVTVGVASTLAYLLLYAALRTGLGAQPANLLALLVTAIGNTALNRRLTFGVRGAAGAARQHAQGLLIFALGLVLTSGSLAVLGALLQQPPRLVELTVLTVANLTATLLRFLLLRRWVFRTA
>NZ_CP022961.1|WP_095567864.1|3435377_3435956_+|CGNR-zinc-finger-domain-containing-protein
MLFTHDTECTLSATAALVNTAGGDTGSGTSDTGNTEGLPDVAALDAFVTAHNWTGRHERTEAELHGVRELRPRLRRIWYADEDGVVEIVNGLLRAAAALPQLIKHDDQPYHLHAVPRDAPLPTRMAVEAAMALADLIRAGELDRLRRCAYPGCANVLVDLSRNRSRRFCDAGCGNRAAVSAYRARKAAGRKS
>NZ_CP022961.1|WP_095565403.1|3447167_3447776_-|hypothetical-protein
MTVEATDRRDWRDITRDATDLATLGILLTIAALPLLSAAAAAGTASAALRDWLDTGSWPPAHRTIDRFRRALLPGAGASLVALAGAGLLAADLIGLAGGAVPGGPPVLVLTGAVAALLAGYVGLVVVEVGHTDGRGWRAAATAVARQCADRPARWLAAVGVSSLVLLLGTLVAPVTVPILVGYALAALHAVTRRLSRTEKLQ
>NZ_CP022961.1|WP_095565404.1|3448690_3449668_-|sugar-ABC-transporter-permease
MAVTTAPEQIHRAPRPVRTARKRSGPGAGGEGLAGYVFLSPWLLGLLGITAIPMLLSLYLSFTNYDVLTPWSEVEWVGLANYRRMFTADPAYWHAVRVTVTFALVAVPLKLAAALGVALLLNKAWRGVGLFRGLFYLPSLLGGSVALAIVWRSMFSGDGAVNSFLGLFGIQGQPWVNDPDWALETLMALAIWQFGAPMVIFLAGLKQVPTELYEAAAVDGAGRSRQFFHVTLPMLSPVIFFNLVLETIHGFQGFTAAFVVSRGTGGPVDSTLMYTLKLYVSGFTNLEMGYASAMAWVFLIAVSVITAVFFSTGRFWVHYSDGTNS
>NZ_CP022961.1|WP_095565405.1|3449702_3451046_-|extracellular-solute-binding-protein
MYAEPTTPADPPAANHRTALPRRRLLSLVAATLIAAPLTFGAAACGGDDSSDDPNAPVKISIFWWGGDARAKLTEDALALYTQKHPNVTFEKTWQANKGYFDKLATLVAGGGAPDIFQIDDNYLTEYASRNATLDLTSLQQSGKIDTSKFPESLWKYGVVDGKLAGIASGENTQGLVYDKTLLTKNGLPEPTTGMSWEEHIAWAQQVTAKTGVPGTQDPSADYKAFWVWLRQQGKDLYQGTSLGFTAADVTAWFDLWKGARDKKATPSPDVIHEGNATDVTTQLVVTGKADTSWVWANQLPELKKNTNNELGVVAYPGDPSGQWARASMYYSVFKGSKHKDAAADVIDFLVNDPEAVKILGTDRGLPSNLDLRQQIADSVDDPAMKLSIQFETEMAGKFGQAPQVPLKGHSTIRSELLKAAEEAQFGRSSSAEAAEQFMAACQAAIA
>NZ_CP022961.1|WP_095565406.1|3451066_3452206_-|LacI-family-transcriptional-regulator
MPATIRDVARASGVHISTVSRTFSAPHLVNPDTRSRVLACAESLGYRPNRAARALITGRTHNIGLIIADIANPFFPPLIKAAERQARQRDYHVFVADTNEDPAAEEELVHALAKQVDGVLLCSPRMSNSLIEQLSREVPLVVINRQITGLPTVVMDNGQGARLAVEHLLGLGHRDLALLAGPRGSWTSREIRRAASAAARSGGATLTVIGPNTPTESSGGALAEQVRRCGATAVLAYNDLMAIGLIEGLDAIGMRVPRDVSVVGIDDIALSRLTRPKLTTVATPTAVAGRTAVDMLLQHDAPAGSRGGRAGGRGTAGDDRRTTAQVTLQTELVIRESTGPGPAAATDRPGIRTTAAGPGPHPTADPGTTTATAGTVVAS
>NZ_CP022961.1|WP_095565407.1|3452443_3453772_+|Gfo/Idh/MocA-family-oxidoreductase
MPASSPGRRRYAVVGTGARAEMFVRALVVDHADRAELVAFADVNQARMDAHNRWLTDLGRPAVPTYRAADFAAMLDKERVDTVLVTTVDRTHDEYIVAAVRAGRDVVTEKPMTVDVPRCRRILDAVAETGAQVSVAFNYRYNPLHEAVRATLAAGEIGEIGSVHFEWLLDVRHGADYFRRWHRDRANSGGLLVHKAGHHFDLVNWWLDSVPERVYAEGRLFFYGPAGQRHGYARDYDRVHGSPAAQDDPFALRLAEHPRLRELYLEAEGEDGYHRDQNVFAPGVTIEDDMAVLVRYASGATMSYHLTAYAPWEGYRVMFNGSRGRLELEVAESTHVSPAAAGALKGAALHGAEAAAEEGSATLTLRPYWAPPRQIPVAGRTRSGHGGADARMARVLFGGEADPHGRTATARDGALALLTGLAANQSMATGEAVRVADLLTVA
>NZ_CP022961.1|WP_095565408.1|3453790_3455221_+|glucuronate-isomerase
MPAAPDLLLPAEPNQRAIARDLYALVAERPLISPHGHVDPAILADDTPFPDPAQLLIVPDHYLTRMLLSQGVPPAELGVPSRDGSPVETDGRRIWRRFAEHWYLFRGTPSRLWLERTFRTVFGVDTALSPQTADRVYDEIADRLAEPEFRPRALFERFNIEVLATTESPLDDLGRHAKLAADGWGGPGGRVVTTFRPDNVVDMEFDGWQDNVARLGEVAGTDTMAYEGYLEALRRRREAFIAAGATSSDHGHPTAGTLSLSAREAAQLYERGLRGGADAADAEAFRAHMLLEFARMSLEDGLVLQLHPGAVRNHNRWLYARHGRDTGGDVPQATEYVHALAPLLDAYGNDPRLRVVLYTLDEYTFSRELAPLAGGYAALYLGAPWWFLDSPEVLRRFRESVTESAGFYNTAGFVDDTRAFCSIPVRHEVARRVDAGFLARLVAEHRLPLDEAAETIVDLAYHLPRKVFRLDGEAHR
>NZ_CP022961.1|WP_095565409.1|3455217_3456507_+|fuconate-dehydratase
MSTTITAVDVHDVRFPTARDGDGSDAINRGDYSATYVELRTDAGPTGAGFTFTNGRGNEITCAAVHALAHHVTGRTVEEIAAEPVAFWRSLTADVQLRWLGPEKGVIHMAAGALVNAVWDLRAKLADRPLWRFLADLPTAELVANIDFRHITDALTPDEAASILDKGLIGLADRCAELDRDGFPSYTTSVGWLGYPDDKVRALTRAAYGQGWRAMKMKVGGELADDLRRARIIRAEIGPDALLMMDANQVWDVDEAIEKMAVLAEVEPYWIEEPTHADDVLGHARIAQAVAPVRVATGEVAANRVMFKQFLQAGALGVMQIDACRVAGVNEVLAELLLAAKFGVPVCPHAGGVGLCEYVQHLAIFDYLRVGTALTGRMVEYVDHLHEHFVDPVRTRDGRYLLPDQPGYSSTMRPESIARFSFPDGPAWR
>NZ_CP022961.1|WP_095565410.1|3458290_3459673_+|pectate-lyase
MRYRRSAARTLAAVLALTAPAALAPTPASAVTPTRAGTAERQLGPAANALGRQVLPDNDGWAAIDSGTTGGSTAGADQVYVVSSRAELVDALGGDNATNRSNATPKIIFIDGRVDGFEADDGHLLDCADLADPDYTLDAYLATYDPAVWGRTNPTGPLEEARVRSVANQTRQTQINVGPNTTIIGRHGASLTGLTLMIDSANNVIVRNLTFVDARDCFPAWSPTDGDTGNWNSQYDNLSVRRSEHVWVDHSSFSDGDNPDSGQPLYFGRPYQVHDGSLDITHTASLVTVTYNRFTGRDKLMLIGSSNTVGPDVDRLKVTVHGNYFDGDLQRLPRVRFGQVDVYNNYYRLGGPDFVYALGVGVQSSLYAENNYFDLNDGTTAADLLYDWGGTAITVRGNWVREGGALPHPVDLLAAYNATHDPDLAGDVGWTPVLRAGPVLPAPLVPFAVRLLAGANRLPV
>NZ_CP022961.1|WP_095567866.1|3459908_3461444_+|pectate-lyase
MTTGAAAATLFSDDFNDGNADGWSKSGGDWSVVTDGTPTYQQGKADSELARVFAGDTGWTSYGVQARVKPLSFNGTGLVGIAARSTSATKMYRLALTSANRAELQVVNGSSITVLGSAALTVSTGTWYTLRIDASGSTIRGYVNGTQIGSGSDSAYSAGRIVLVTVYATARFDDVVVDSSGTTPTTAAPTTAAPTTAAPTTAPPTTAPPQTGVSGWATQGGGTTGGSGGGTVTVTSASALTSAVSGDSAQTVRVSGNFSCSTEIRVGSNKTILGVGSGSGLTGCGLNLRDAHNIIIRNMQISKVQASTGNGDALHLDNTTNVWLDHNDLSSDTTHGTDYYDGLIDITHASNYITVSWNKVHDHVKCSLVGHSDSNSSEDTGKLKVTYHHNYFSNCFQRNPRVRFGNPVHVYNNYYYLSPGTSDYSYGIATTCNAGVLVEGNYFENEPDPTHVGEGSSPNGNLVQRNNYFVNSGTPETNGSVASIPYSYTLDSASGVKASVTAGAGTGHIST
>NZ_CP022961.1|WP_095567867.1|3461622_3462060_-|hypothetical-protein
MHGCPRPDAGSDPPRALPLREVRTRLTQLVGLAEVNDTVTMITRDGDPRPVAAIVPAAAARTAAQARADADRVAAVSAGWARRLEEQHRRGAHRHAAELRALATALAEAWAELDRRAGPGGDPALARLRAGHAALLTDVREATAA

Crispr_ID: NZ_CP022961_14

• CRISPR_ID: NZ_CP022961_14
• CRISPR_location: 3542084-3542193
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_14

Consensus_repeat	Method
CCGGCGCCCCGATCTGGATCCCGCACGCGGCG	CRISPRCasFinder

spacers of NZ_CP022961_14

>14.1|3542116|46|NZ_CP022961|CRISPRCasFinder
TCCGCGAGCTGCGCGGAGCTGCGGTTGGCGAGGATCTGGCTCAGCT

CRISPR arrays and Neighbor proteins around NZ_CP022961_14

CRISPR arrays

The CRISPR arrays of NZ_CP022961_14

>merge|NZ_CP022961|14|3542084-3542193|CRISPRCasFinder
CCGGCGCCCCGATCTGGATCCCGCACGCGGCGTCCGCGAGCTGCGCGGAGCTGCGGTTGGCGAGGATCTGGCTCAGCTCCGGCGCCCCGATCTGGATCCCGCAAGCGGCG

>NZ_CP022961|14|14|3542084-3542193|CRISPRCasFinder
CCGGCGCCCCGATCTGGATCCCGCACGCGGCG	TCCGCGAGCTGCGCGGAGCTGCGGTTGGCGAGGATCTGGCTCAGCT
CCGGCGCCCCGATCTGGATCCCGCAAGCGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_157756781.1|3526320_3527124_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP022961.1|WP_095565460.1|3545451_3546039_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NZ_CP022961.1|WP_157756784.1|3542437_3542719_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NZ_CP022961.1|WP_157756782.1|3530616_3533196_+|aminopeptidase-N	unknown	unknown	gnl|CDD|274121
NZ_CP022961.1|WP_095565465.1|3553134_3554004_-|methyltransferase	unknown	unknown	gnl|CDD|252734
NZ_CP022961.1|WP_095567879.1|3535984_3538042_-|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl|CDD|235501
NZ_CP022961.1|WP_095565458.1|3542664_3544965_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NZ_CP022961.1|WP_157756785.1|3544966_3545455_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565463.1|3550389_3551040_+|hypothetical-protein	unknown	unknown	gnl|CDD|223498
NZ_CP022961.1|WP_095567878.1|3528208_3530452_+|formate-C-acetyltransferase	unknown	unknown	gnl|CDD|153087
NZ_CP022961.1|WP_095565449.1|3523543_3524854_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NZ_CP022961.1|WP_095567881.1|3554182_3554446_-|hypothetical-protein	unknown	unknown	gnl|CDD|225993
NZ_CP022961.1|WP_095565453.1|3533342_3535835_-|DNA-topoisomerase-4-subunit-A	unknown	unknown	gnl|CDD|235503
NZ_CP022961.1|WP_157756786.1|3546067_3547321_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173787
NZ_CP022961.1|WP_095565462.1|3547531_3549190_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP022961.1|WP_095565451.1|3527414_3528035_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP022961.1|WP_157756783.1|3539455_3540709_+|glycosyltransferase	unknown	unknown	gnl|CDD|340860
NZ_CP022961.1|WP_095565464.1|3552418_3553066_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NZ_CP022961.1|WP_157757010.1|3524863_3525787_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NZ_CP022961.1|WP_095565455.1|3540765_3541950_-|radical-SAM-protein	unknown	unknown	gnl|CDD|275256

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_157756781.1|3526320_3527124_-|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.09656e-11
NZ_CP022961.1|WP_095565460.1|3545451_3546039_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	9.80851e-19
NZ_CP022961.1|WP_157756784.1|3542437_3542719_-|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.58576e-16
NZ_CP022961.1|WP_157756782.1|3530616_3533196_+|aminopeptidase-N	gnl|CDD|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP022961.1|WP_095565465.1|3553134_3554004_-|methyltransferase	gnl|CDD|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	7.34751e-104
NZ_CP022961.1|WP_095567879.1|3535984_3538042_-|type-IIA-DNA-topoisomerase-subunit-B	gnl|CDD|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NZ_CP022961.1|WP_095565458.1|3542664_3544965_-|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	5.8709e-09
NZ_CP022961.1|WP_095565463.1|3550389_3551040_+|hypothetical-protein	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	2.71914e-21
NZ_CP022961.1|WP_095567878.1|3528208_3530452_+|formate-C-acetyltransferase	gnl|CDD|153087	cd01678, PFL1, Pyruvate formate lyase 1. Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.	0
NZ_CP022961.1|WP_095565449.1|3523543_3524854_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	2.76838e-79
NZ_CP022961.1|WP_095567881.1|3554182_3554446_-|hypothetical-protein	gnl|CDD|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	9.02547e-06
NZ_CP022961.1|WP_095565453.1|3533342_3535835_-|DNA-topoisomerase-4-subunit-A	gnl|CDD|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP022961.1|WP_157756786.1|3546067_3547321_-|S8-family-serine-peptidase	gnl|CDD|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	4.07982e-21
NZ_CP022961.1|WP_095565462.1|3547531_3549190_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.0005959
NZ_CP022961.1|WP_095565451.1|3527414_3528035_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.30839e-08
NZ_CP022961.1|WP_157756783.1|3539455_3540709_+|glycosyltransferase	gnl|CDD|340860	cd05844, GT4-like, glycosyltransferase family 4 proteins. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	6.3268e-89
NZ_CP022961.1|WP_095565464.1|3552418_3553066_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	7.62962e-13
NZ_CP022961.1|WP_157757010.1|3524863_3525787_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.97094e-84
NZ_CP022961.1|WP_095565455.1|3540765_3541950_-|radical-SAM-protein	gnl|CDD|275256	TIGR04463, Radical_SAM_domain_protein, radical SAM/SPASM domain protein maturase. Members of this family are probable protein/peptide-modifying radical SAM/SPASM domain proteins. The majority of members of this family seem to target Cys-rich repetitive regions of large proteins rather than of bacteriocin-sized small precursors. This arrangement suggests the modification target may be multifunctional, with the C-terminal domain behaving like a bacteriocin but other parts of the same precursor serving an immunity function, as occurs for the halocin C8 precursor.	1.76695e-32

Protein sequences

>NZ_CP022961.1|WP_095565455.1|3540765_3541950_-|radical-SAM-protein
MIGTRLDDVDAPRLIRSEFGWWFVGNQTWTLLRPDCVRPDGTVDEDTTGFLRRAGAFRPRTPASYSLTVLTTTTCNLGCGYCFQNTGLDEAGGARPPRIRRAWLDAGTVERIIAFTRDRMRRCELDRLHLLLFGGEPLLNPRGCRTLLEQARSIGLDQCAMTTNGVLLTVKLARELYAAGLNGVQVTFDGSRADHDQIRVKRSGAPTFDTILRNVARATEATGLNWNLRVNVSHHNFDRIGDLVGELAGDLSPDRCTVTFAWVGDVGFGYHNTMRHIDEVSAAFANWSIAALEAGFRMVRPSMRTTCHICSAPGGRYGAVVNADGQLFSCWQSAGKPGFEVGSVDRGYLEPASVPDRWVRCGYEYEQPEPTVADAFQDRVDGRLLDYLYTSGRL
>NZ_CP022961.1|WP_157756783.1|3539455_3540709_+|glycosyltransferase
MSGADSDPPGPDGPAGDSDPAGPGGPAGDSDPAGPGDAAGDDAEPRRRVVIWRSCLLPASETFVRNHGAALVRWRPTYLGAVRVDSPLALESDTIAFPDTPAGRRGWLGLRLTGRSARLRDLLAGLDPALVHAHFGGDGRLIAASARRLGIPLVITLHGLDVTRQAAAAGPRGLRHRRNLRAAFARASLILAVSGHIRDRAVELGADPAKLRVHHTGVPVPAEPATAAKRWDVAFVGRFVAKKGVDDLVAALRRSTRGPRAVFIGAGPLYALMRDRAARWGLDVTFLGAQPPSVVARHLAEARILVAPSKTADDGDAEGLPTTILEAAALGVPVVSTYHSGIPEAVLDGETGLLCPEADPVALAAAIDRLLADDGLRERLGRQARRRVRERFDIAVQTRRLERLYAATAKIDTTSAK
>NZ_CP022961.1|WP_095567879.1|3535984_3538042_-|type-IIA-DNA-topoisomerase-subunit-B
MTAQSDIRYGADDLTHLEGLDAVRKRPGMYIGSTDSRGVNHLVNEILDNATDEGVAGHATRIEVTLGADGSVQVDDDGRGIPTDINARSGISGVELVLTRLHAGGKFGGSGYKTSGGLHGVGASAVNALSHRFDVSVRRGGQVHEISFRRGVPGEFDGAGPDADFTSRPGLRVARRMRRGEPTGTTIRYWYDARYFETGAALDVEAVRSKLRNTAFLVPGVTYVLRDATAGEPAEEVFHFPNGLADMVDFLAPPGDRPVCDTLLITGEGSYRENAADANGVMQANVARRAEVEIALRWGTGYDRTVECFSNTIRNAHGGTHRRGFERAAVRALTEAIRGTRGLLRPKEDPPTVEDVLEGMTAVVHVRIPEPQFTSQTKDELSTAGITKVVQTVVEQHLRAWTEARRSRTEARTVLQKIVDAARVRLAHKQQKDAARRKTALEGAAMPAKLVDCRSTGIDRSELFIVEGDSALGTSRMARSSEYQALLPIRGKILNVQKASLQQVLDNAECSSIVQVLGAGSGRTFDLGAMRYGRVLIMADADVDGSHIRTLLITLFAKYMRPVIEAGRLYAAMPPLHKIVTKGRNPETIFTYTQAEMETTVARLEKRGRQVVTPIPRFKGLGEMDADELWDTTMNPAARSVRRITLHDIEAAERTLELLMGEKVEPRKNWLIDAAGRIDQSAIDA
>NZ_CP022961.1|WP_095565453.1|3533342_3535835_-|DNA-topoisomerase-4-subunit-A
MARRKDSSPARVDLTAFDQPGAQVFDNPLTTEVEDSYLEYAYSVIHSRALPDARDGLKPVHRRILWSMSEQGHRPDRAHVKSARVVGDVMGRFHPHGDLAIYDALVRMAQGFSLNTPLIDGHGNFGSPDDGPAASRYTESRLSEAAMLLVGELGEDTVDPKPNYDGSLTEPTVLPAAFPNLLVNGAAGIAVGMATNMIPHNLGEVVGAARWLINHPDASLDRLMEFVPGPDLPTGGLLLGLDEVRRAYETGRGVVRMRARVRTGPLEGSRGRQAITVTELPYGVGAEKVIEKITDEVTRTKRLQGIADVKDLTDRENGIRVVIECKVGVNPQALLADLYRLTPLEQSFGINNLVLVDGQPRTLGLKELLEVFLAHRYEVVTRRTSYRRRRRQERLHLVDGLLIALLDIDRVVRLIRSSDDAQAARDGLMREFGLSEIQAGYILDTPLRRLTRFDRLELEAEQERLRAEIEELSRILDDDAVLRRVVSDELAEVGRRFAAARRTTLIDGDLKEVLAASAPAGPLEVADDPCQVILSATGLVARTAAESEEASEGQRRNGRVRHDAVRALVHSTARGQVLLVTSRGRAFKTDVLPLPVLPQQTGTVSLRGGMSAAELVPLEAGEVVVGLAPLGGADQGSPGLALGTRQGVVKVCAPEWPVRSDQFDVIGLREGDEVVGAVWLTDGAEQVVFVTSDAQLLRFGAGLVRPQGLKGGGMAGVARAADAEVIFFGAVRTDDTEHGEPLVVTSTGLGVKVTPFAEYPAKGRATGGVRVQRFLKGETRLAVAWVGPRPAAATGAGEPVELPEPNPRRDASGTPVLLGPEVVGHRIERG
>NZ_CP022961.1|WP_157756782.1|3530616_3533196_+|aminopeptidase-N
MTSLTRDEARTRAELLRVRRYDVELDLTGLLCGTTLRSRSTVDFSARRTDEPIFVDIVADEVRAWLDGAALPAEAYDGERLTLPALGGDHQLVVAASTDRTEQRTGIHRWVDPADGGTYVWTSFEPDDARRVFACFDQPDLKAVVAFTVHAPAGWTVVSNSAVLECTDRAGDTAPADGTRPADGTGPVDGTGPADDAGSGAGAARTWRFADTPRMSPYVTVVCAGPFHQVRRTVDGYDLAVLARRSLAAHLDRQAPELFDLTAAGLRFFGEQFDMPFPQRTYTQVFCPDFQGAMENWGCVTWMDSALYRTEPTDAQRERRAVVLLHEMAHMWFGDLVTMRWWDDLWLNESFADWAAMWAAERCTPFTGAWVSFLGDRKEAGYSADGGPTTHPVRQEIATVDDARAAFDRVTYSKGASVLRQLTAYTGEEPFVAGLRRHFARHAYGNATLEDLLASVAGPSGRDLATWAREWLLTAGTDTMSVRTDTDAEGRYRSVEVLVEPPAERPANRPHRLAVGVYDITDDRPVLRRRVELDAAPPATAVPELAGAPAADLLLVNDADLTFARVRPDAPTRAAMLRYGPSLPDPLSRAVTRLTLWHLVEDGLLAPDEVVRYAARALAVETDPAARAGLLGTAERAVRNWVDASAVPAVGDELAAACAALARAAGERDEPATVRAALRAALAVAYRPERLAELDELVGDDVDLRWHWLTQVAATGGYDPDAVAKLLDRDPDPDSAGRAAAVRAARPDSTAKDEVWREIFTGALPLPMLPAVGQAFWDPGQGDLLAPFADRFLDELPTLGGGMTTVMVTIGSLFPTHGVDRDFPARVEAAADRLPPLAAARVLDRSHVLGQMLRARAVR
>NZ_CP022961.1|WP_095567878.1|3528208_3530452_+|formate-C-acetyltransferase
MRNPTERGAWRGFTGQGWRARINVAAFVRDNVTPYRGGPDFLTGPTPRTTALWDGLRAMFVEERRRGIHDVDTRTPAGITAHRPGYLDRDRELIVGLQTDAPLRRAIMPAGGLRMVEAGLAAYGYELDPTVRQIFGTYRKTHNEGVFDAYPADVRAARRSHIITGLPDAYGRGRIIGDYRRVALYGVDRLVFDRRALKEALDERHSTVDVIRDREELAEQIRALDELKRMAAGYGYDIGRPAETGREAIQWLYFGYLGAAKEQNGAAMSLGRTASFLDCYLQRDLAEGTLTETGAQELIDDLVIKLRIIRFLRTPEYDEFFSGDPTWVTEALGGLGADGRPLVTRTTYRYLQTLYNLGPAPEPNLTVLWSPALPTEFKRFCARVSLDTSAIQYENDDLLRPRYGDDAAIACCVSAMRVGRDMQFFGARANLAKALLYAINGGRDELTGAQVAPAGPPVDGEYLDYAQVTAALDRTLDWLAETYVDALNVIHYMHDRYAYERLAMALHDYPVHRYLATGIAGLSVAADSLSAIRHARVKVLRDESGLVTDYAIEGDFPTFGNNDDRADAIAVELVESFMARIRRQPTYRHAEPTLSVLTLTSNVVYGRHTGNTPDGRRAGEPFAPDANPMNGRDRHGLVAAALSVAKLPYDSARDGISLTSTVTPAGLGHTRDERVDNLVGVLDGFTDAGGFHMNVNVLDRATLQDAMAHPERYPQLTVRVSGYAVNFVRLTPEQQRDVIGRTFHGSI
>NZ_CP022961.1|WP_095565451.1|3527414_3528035_-|TetR/AcrR-family-transcriptional-regulator
MGKGDQTRQAVLDQAVEVGRRVGLGGLTIGSLAEQMRMSKSGLFAHFRSKEGLQVSVLEHARTAFEDTVARPAIRAPRGEPRLRELFERWLVWAAAPGGCPFIAAAVEFDDQPGPVRDRLVRDQRDMLDMIATIFRTGIAEGHFRPDADPDQFAQDFDGVLLAFHHLCRLFGDERAESRARRAFGALLDGARPGPAEDGRAAPAAR
>NZ_CP022961.1|WP_157756781.1|3526320_3527124_-|alpha/beta-fold-hydrolase
MTPAGSQPASPAPAGRPFAVAVDGHRVVGESWGSGPVVYLLHGWAGRSRQLASLVTPLVERGHRVVAFDAPSHGRSAPGRYGPRSSSIPEFAASLAAVAQMHGRPHAVVAHSLGATAAAVALCDGLPADRVVLLAPMASPASYAEQLRGALGFGRRILCRLTVRVERRVGAPMRHFDVPEIGRAVAVPGAGRARPGRRRGAVRRRRRDRRRLDRGDPAGDRRARPSPVVARPGGDRRGGGLRGRSRSVSRSGKAVAMGAIPDYIDMG
>NZ_CP022961.1|WP_157757010.1|3524863_3525787_-|SGNH/GDSL-hydrolase-family-protein
MRTVTFHGRVPVRVPAGHDVLSDPVPLTVPDRADLLVSVFVQRQAGPATQHQLAMRTSYLAPGGDHAADPADPADPDGQPFTGETSTWFFATGVDVLATGIRGAVVAFGDSITDGYMSSYGADHRYPDFLAQRLLRQPPGRRMAVQNAGISGNRLLLPGMYDAFGPSATERLDTDALSRTGARSLLVLEGINDIQQEPHQTDPDRIVAALREIAHRAHRHGLRVIIGTMTPFEGWPDYTPELEVVRVAVNDALRGDPAFDAVVDFDRVVRDPAAPQRLLPAYDSGDHLHPDDAGYAAMAAAVDLDQL
>NZ_CP022961.1|WP_095565449.1|3523543_3524854_-|SGNH/GDSL-hydrolase-family-protein
MSAYPDVRFPTTAPRRRLGPVAVAAAVALVLAGGALVRSASGSPPAGSPPGGSAPGAGTWVAAWAPSPVVGSDIPWSDCPAGAGLADQTVRNVAFVTAGGSAVRVRITNTFGETPLKVDHASVAVQGDGAAARAGTVRELTFAGRPTVTVAAGGRALSDPVRLSVAALSTLLVSVHVPDPTGPVTNHPFTAQGNYLAAGDRALAAGADGYADTPCWMLVDGVDVRGTDRIGSVVALGDSITDTANTTGNANHRWPDYLARRLDGRPGPTLSVVNEGLGGNRLLAPRDDGAYWGVPALARLERDVYAQTGVRAVIMLEGTNDIGFSAPAADIIDGYRQVVAQTHAQGLPIFLGTVPPLGGSFMDTPQQRAIWREVNDWIRTHREADGVVDFARVLGDPADPETLLPAYDSGDHLHPNDAGCAAMADAVDLAALFRRR
>NZ_CP022961.1|WP_157756784.1|3542437_3542719_-|CHAT-domain-containing-protein
MLRRAPRTVVLSCCDLGLSDVRHGDEALGMTTALLAAGTATVIASVGRVADDAATETMVACHRAVVAGRSPAAALAEAVRGRHAPGFVCFGAG
>NZ_CP022961.1|WP_095565458.1|3542664_3544965_-|CHAT-domain-containing-protein
MEPAALARRAVRWHSAGLASSDAGQPGRAARELRAGLRLARRQPALRDIHARLLISLAWAESERGRVGLGFRLLDEAETLVAAPQRPILLGQRALLLKRSGRNAEALRQYDEAVGLLSDLAQPRDLVKALNNRSLVHLEAGRVRLARSDLRRCAEIAARHGLGLHVAMARTNLGCLDVIAGDLPSALRAFALSDADYRVLAPGRLANLAVERARALVAAGLYREADRQLAGAVREATQQQLGHVYADALQVRAEAALLADDPVAAARWARLARAAFLGRTNVRRAALAALLELRADQAAGAVDPEALARRASVLAGRLTRLGLPEDARVAEMVRVRALVAAGRGRRAAELLARQAGPRRTDRLDTRLLWHMARAEVAACAGRSAQARRSLLAGMTALHRHRSRFGCADLQTGAAVHGRDLARAGLAGALAEGCATAVYRWSERARAQALLLPPVRPPDDPVAAQALEELRQLRHSVRQAELAGRPTRAFHGRLEVLQRVIRERAWATPGPRDAAPPTPAPLTAVTAELAGAALVLYVAAGNVLRALVVTDRAVSVVVLGDLGAAQEAVRRLSADLDAQAGRSMPERLTAAVHAATRRDVDRVAATVLDPVLPLVGDRELVVVPTGVLLSTPWHALPACASRPVTVAPSVAVWLAARRRLKADRPADGSAVTVVAGPGTHRGEAEARAVASLHPGAVVLTGPAATPAATLAAMTGASLAHVAAHGQHQTENPLFSTLELAGGPLLGTTCRCCGAHRVPSCCPVATWA
>NZ_CP022961.1|WP_157756785.1|3544966_3545455_-|hypothetical-protein
MTAPHSADQPIDDLDQAILDHLAVVLTRLDPPPTDLDDRVRLVLALDDLDREVARLRDEQLVGGVRGTERTRTLTFDAESRTVMITIVDRPDGLVRIDGWLAPGAAVRVELRHPAPGPAQVVQSDASGRFVLDGVPHGLAQLIVHPAPGEHAPQVVTPALGL
>NZ_CP022961.1|WP_095565460.1|3545451_3546039_-|sigma-70-family-RNA-polymerase-sigma-factor
MEHAEAPHDRVARLADCLERARAGDRDALNDVVRELNPLLWRVARAQGLTTEEAADVVQTTWLELVRALHTIRSSRALTAWLVTATRRESWRVRGLAQRQAPHDVTILESSPDPDPGAIDLLLSEERDRALWRHVARLPERCQALLRIVAHVNRPDYTAVAEALGMPRGSIGPTRGRCLAKLREVLAADPTWSPT
>NZ_CP022961.1|WP_157756786.1|3546067_3547321_-|S8-family-serine-peptidase
MSHRRYRPDVVLAPAWVVQRPETVERLNGLLAQAGLGRPLSPPAARTAPGTELVELPVTGDPVAVARACRRLAGRSDAAVPECLPDYECAAATVEDDARVQRSLYPYYRASGRKSGHGTVAWLPAPEHVMPPKPPRRPASRFPAGRPVVALLDTGVREHDWLVETDGDPYWQEAQDWTPARPIAEIAGQDSHGEESDGPDSGGPDSDGPDGGGPDGGGTDFGSHWGHGTFLAGLVRLAAPDARILSLRVMSDAGRVSDLNAAHALNWLADRVREGQRIDVVLTAFGRAGLGARQEMEPVRAALRRLADQGVPVVASAGNGGTDSPVYPAAFAADPTLTVVSVGARVSPTSRAPYSSHGVWVREWQEGTNVVSTMPLTTTPVAVQGGYAYWSGTSFAAARYAGRLAQSMVPAPARLPD
>NZ_CP022961.1|WP_095565462.1|3547531_3549190_-|hypothetical-protein
MTVRLIGGEMLNWSDLDGRHGPGPVRGAALSPLLALARGRTLVAGPHHPDLLDGLPDGDLTLLVRGVPDADALAERYRHRPRITVCCGGPEKLPAQPPYDTVIALDGLRRLASAEGAQLPWAEGLELLLAALRPGGRLLLGMENLLGLHRLVALPRERTDTDWGTPEEYDPSRPAGLRRVLAYLDGAGLTVTDSYAGFPGAYEPTVLLGADVLADAAITGFLESTLAVACAPAEAVLTDPVRLATDALRHGMAGELAPGWVLLARRRADDGSDDPDRGSGARPAAGADPPGGQPPAAVLATAEPTGVLRPAAAGGWLRRPAGSAADGVAVPAGPTLWRVLLTACLRHDLPAVRDLLRDWQAGNAAGVPADRLIVEPGGRLVPLAPAGDPAAALRRCAALLLAGDHPHPWPAATGEAELAAILAGMAGRDPASAEPAGAGPGPVVPAGREPDPAAGSAPGAPGERERRPDMPAFRELVRTRDRLVAELAAARAAADAWERLVAERERSLVEARRTIDLLSAAGPARAGRALLGGARAARGSARSVVRRWSGRG
>NZ_CP022961.1|WP_095565463.1|3550389_3551040_+|hypothetical-protein
MDEVTTVDRVRTDRGELALRRSGPHYEIISNGVFLMDTRAGESERLLVRAALDAVGPGSRMLIGGLGVGFSVAEAVASTRPAQIVVVEIERTLVRWHRDHLAPYSRNALDDPRVRVVARDLVDWLAETPDRYDAICLDVDNGPDWTVFDGNAALYGPQGLALLRDRLAPGGVLAVWSAAAAPGYAARLASILGPVSELRVEVPRGEPDVVYLAHRV
>NZ_CP022961.1|WP_095565464.1|3552418_3553066_-|PadR-family-transcriptional-regulator
MAKRRKVGNLLGLAVLSVLAQRPMHPYEIAGALRGWGKDQDMAIKWGSLYTVVRNLDKHGFIAAVESVREGRRPERTVYRITDAGRAELLDWARELISSPEPEYPRFRAGLSVLPVLHPDEAAALLRDRLAQLDRNAAAARETLAGHLREVPRLFLIEDEYDLAAMRAEADWIRSLLAEIDAGTLPGLAGWRTFHETGEMPAEFAALAERTSSTE
>NZ_CP022961.1|WP_095565465.1|3553134_3554004_-|methyltransferase
MSSAAIRPHRLRRTAVPPTSDADQTAPDRRLDSHTVSPARRWNYWLGGKDHFQVDRDSGDRIAAVYPPIRTAAREGRAFHGRAIRYLAGTAGIRQFLDIGAGLPAPANTHEVAQAVAPESRVLYVDNDPMVLAHARALMVGTPEGATRYLDADLREPASILESPELAETLDLREPVAILLIAVLHFIRDDQQAHRIVADLLRAVPPGSYLVATHGTSDFVDPETAVRFAALGNKGQVDVWPRTEAGVAAFFAGLELLDPGVVPVSDWRPESADRPGRSEVATYAAVGRT
>NZ_CP022961.1|WP_095567881.1|3554182_3554446_-|hypothetical-protein
MAYGHPAWNGGPWAGHGPGWWIIFPILFWAVLLGAIGYLAYRRSPGQQARAAAERTLAERFARGEIGADELAERRAALRNSTRRRTS

Crispr_ID: NZ_CP022961_15

• CRISPR_ID: NZ_CP022961_15
• CRISPR_location: 3714908-3715035
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP022961_15

Consensus_repeat	Method
CGGCCCCGGTAGCGGGCCGGCCCCG	CRISPRCasFinder

spacers of NZ_CP022961_15

>15.1|3714933|27|NZ_CP022961|CRISPRCasFinder
GCGCTGTCCGTGCCCCCGCGTCCGCAT
>15.2|3714985|26|NZ_CP022961|CRISPRCasFinder
GTAGCGGGCCGGCCCCGGTAGCGGGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_15

CRISPR arrays

The CRISPR arrays of NZ_CP022961_15

>merge|NZ_CP022961|15|3714908-3715035|CRISPRCasFinder
CGGCACCCCCGGCGGGCCGCCCGCGGCGCTGTCCGTGCCCCCGCGTCCGCATCGGCCCCGGTAGCGGGCCGGCCCCGGTAGCGGGCCGGCCCCGGTAGCGGGCCGGCCCCGGTGGCGGGCCGGCCCCG

>NZ_CP022961|15|15|3714908-3715035|CRISPRCasFinder
CGGCACCCCCGGCGGGCCGCCCGCG	GCGCTGTCCGTGCCCCCGCGTCCGCAT
CGGCCCCGGTAGCGGGCCGGCCCCG	GTAGCGGGCCGGCCCCGGTAGCGGGC
CGGCCCCGGTGGCGGGCCGGCCCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565555.1|3715041_3715335_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NZ_CP022961.1|WP_095565558.1|3726302_3729839_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP022961.1|WP_095565559.1|3729793_3737527_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP022961.1|WP_095565562.1|3742206_3743103_+|universal-stress-protein	unknown	unknown	gnl|CDD|366180
NZ_CP022961.1|WP_095565551.1|3708951_3711042_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|274856
NZ_CP022961.1|WP_157756800.1|3737555_3738002_-|hypothetical-protein	unknown	unknown	gnl|CDD|227179
NZ_CP022961.1|WP_157756796.1|3700417_3701806_+|DUF2079-domain-containing-protein	unknown	unknown	gnl|CDD|370724
NZ_CP022961.1|WP_157756798.1|3715434_3717153_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565544.1|3696309_3699270_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NZ_CP022961.1|WP_095565547.1|3701934_3703344_-|hypothetical-protein	unknown	unknown	gnl|CDD|274855
NZ_CP022961.1|WP_095565553.1|3711891_3714591_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|163057
NZ_CP022961.1|WP_095565552.1|3711194_3711890_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP022961.1|WP_157756801.1|3743172_3743826_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565557.1|3723734_3725246_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP022961.1|WP_157756797.1|3703705_3704029_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NZ_CP022961.1|WP_095565561.1|3738235_3739027_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_157756799.1|3721918_3722863_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565550.1|3708216_3708948_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565548.1|3703349_3703661_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NZ_CP022961.1|WP_095565545.1|3699342_3699894_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236605

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565555.1|3715041_3715335_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.77629e-09
NZ_CP022961.1|WP_095565558.1|3726302_3729839_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000110541
NZ_CP022961.1|WP_095565562.1|3742206_3743103_+|universal-stress-protein	gnl|CDD|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.72051e-26
NZ_CP022961.1|WP_095565551.1|3708951_3711042_-|S8-family-serine-peptidase	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	2.06253e-46
NZ_CP022961.1|WP_157756800.1|3737555_3738002_-|hypothetical-protein	gnl|CDD|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	0.000119492
NZ_CP022961.1|WP_157756796.1|3700417_3701806_+|DUF2079-domain-containing-protein	gnl|CDD|370724	pfam09852, DUF2079, Predicted membrane protein (DUF2079). This domain, found in various hypothetical prokaryotic proteins, has no known function.	8.51217e-55
NZ_CP022961.1|WP_095565559.1|3729793_3737527_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.24412e-16
NZ_CP022961.1|WP_095565552.1|3711194_3711890_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.19327e-35
NZ_CP022961.1|WP_095565547.1|3701934_3703344_-|hypothetical-protein	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	3.01722e-13
NZ_CP022961.1|WP_095565553.1|3711891_3714591_+|AAA-family-ATPase	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	1.54883e-83
NZ_CP022961.1|WP_095565544.1|3696309_3699270_-|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	3.10954e-26
NZ_CP022961.1|WP_095565557.1|3723734_3725246_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.93319e-07
NZ_CP022961.1|WP_157756797.1|3703705_3704029_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	6.46542e-12
NZ_CP022961.1|WP_095565548.1|3703349_3703661_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	5.95026e-09
NZ_CP022961.1|WP_095565545.1|3699342_3699894_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236605	PRK09645, PRK09645, ECF RNA polymerase sigma factor SigL.	1.02233e-39

Protein sequences

>NZ_CP022961.1|WP_095565553.1|3711891_3714591_+|AAA-family-ATPase
MGVTLGAGQRVAARGWGSHRTIAAAVRAAAEGAVVTVTAGVYRESLLIDRAVTIVADGEVRIDAGTGPALLVRAGTVRVRGLALRGPTADGTAVAVTGGTLDLTDCDVSGGRLVVEGWGKAELTGGRLHGCTGPALAARGDATARLTGTVIEDVDGPGIEVAQSASVELASTVTTRVTGAAVAMLGGTATLVDCEIAEAGSGLSAGGTGPVTVRGGRLRDITGDGIRAGATAVLDLRDTALHRCGGNGIASDGQARVEAHGCQIRRCGAAGVFASAGSLVRLTGCEVRASDVSGLVVRESARLEADDCTVASSGGNGVFGCDTATFRLSGCTIEESGFTAVHLGDAALGELDRCTVRTTPEHGVRATDRAMLRLDGGAVEDAGMTAVHLDGQADATVRGVRIRRAGVGFDIRDTGHHPLVEGCVVAEIGRTGFQAGPLTSPTVRDCTFTHTGAAGIVLERASRAAVDSCTIGDAGGSGLVVCDDAVPVIRSVAVERCRGAGIHLAAGTAGRIEDCTVSGTDGVAVYVGERATPTLRTCRIRDVDRDVEVAPDARPVFQRCASTGVRLATLPTDPDGRAVPGGPEVPAGRGVPGGPDRGSGSGSGHDGAAADADPAERLADLLRQLGELVGLHRAKQDVGTMVQLMRMVRRRQEAGLLPPPLSRHLVFAGNPGTGKTTVARLYGQILAALGILATGHLVEADRGTLVGEYVGHTAPRTQAAFRRALGGVLFIDEAYALAPDGRGNDFGQEAISTLVKLMEDHRDEVVVIVAGYPDQMERFVRVNPGLESRFTRTLTFDDYSPAELVEIVAHQAAGHEYRLSGPTRDALAGYFRAADRGEGFGNGRFARRVFQEMTERHAQRIAELVSAGTTEVDTDQLSTLTPADLPQVEGGSEGFPPPG
>NZ_CP022961.1|WP_095565552.1|3711194_3711890_+|response-regulator-transcription-factor
MQAATTAGGTVPAGTAVCSGRDAAVTVAIVDDQPIPRSGLEHLVSGMARVTVAASVGSIEELDPCDRYDAVVLHLPAADDGLSLKSITRAAEAGHPLVISAWDRPPGVLAALRAGARGCVLRRSTHRTVVCALEVVAAGGLYLCDSLADRFHIELSRPAGADPHGLAPREAETLRWIGRGLTHAEIAHRMGLTPATVNTYAKRIRGKLKVSNRSELTRIALELGQLPDAPA
>NZ_CP022961.1|WP_095565551.1|3708951_3711042_-|S8-family-serine-peptidase
MPATQWPARTPGGRRPARTPGAWRGARPRVLLALLAAAFGVAGSLGGSPAASAEPTEAPYLKYYVVTPAYQGRPENLTEIAERFLGNGSRSAEILDRNVDRIQPDGAALTDPDRLHAGWVLLLPWDAYGDGLRYGLPPTAPAAAPPAGQVGGPSDPGTPAPANPTPANPTPAARCAGTPKDGAGGQDQWAVLRVAPEHAWPYSRGAGVTVAIVDSGADGSRPELAGRLSGGADIPTGSGRGDVDCLGTGTAMAGIVAGRADGGGAAGMAPDASVYPVRVATSSTAAAETDQASAVEVAVAAGAGVIALGGYVDPTRPAVARAIASALAHDAVVVAGASAAGQAPAPGLLRVAAIDIAGAVAGGYGTGQVDVVAPGVDVASLGISGTGQVRHSGSRYAVAFVAGQAALVRSRFPDLTAAQVVRRIEATADRVGSSAPDARYGWGLINPGEAVTRVIMDEGRRPEAPVAPAGDSGWSGQRLLALVVAVLVALLLLALLALRIRKLVRAAPGPAPSEPATVACPDPVADPARVAGPVAAGGPAGAAEPEPAAEPERGVAPDRAMIPAAQSEAAEHARSATGDRVLVGVGPAERPRARGTLLGRLAPDTAGGTPAPPGGPGPGGPDAGTGSGGSDAGGSDAGTGSGGPGTGGPDAGGAGPGGSDAGGARGPGPAGAPRAAREPGAVTAPEGWWRHGPGAG
>NZ_CP022961.1|WP_095565550.1|3708216_3708948_-|hypothetical-protein
MTISPPSTGSPRQQRREAVAALVENGWARVDVPRPAARPHVVLMVAALAAAAALGTGVVLQLVRPVPLPGTDRPAAPPAVAAFTAVSGWDCATAADRGFDVQGRTAQWYTVARGGWTGDGCHGTFEAVPTSGDPATEGPQRAVWWFAPGTAYTRCAVEVFRPAPARARDAAIRAARYYVRAGRDGARLAAFDLDQTAGPGTWAAAGTFPVSAGGVAVELVDRGVAPAAGDRLAVTQVRVRCTG
>NZ_CP022961.1|WP_157756797.1|3703705_3704029_-|WXG100-family-type-VII-secretion-target
MEFKVTPETLVAAATNCRSVNSTIQNDIAAMRAYVAGLMSTYQGTAALALQALSDQWGRDATALNEVLNTIATGLDSNAGNYVESETTNTNNFQNLLGNLPRPGSDS
>NZ_CP022961.1|WP_095565548.1|3703349_3703661_-|WXG100-family-type-VII-secretion-target
MPDPMGTRITVTEELASSGTTILDIATRIGTELSTLKTQLAPLHEYWAGQANVNWQDLQKKWDTAAADLMSAPGQLGAIGNTATVNWTNYTDCETANINTWTH
>NZ_CP022961.1|WP_095565547.1|3701934_3703344_-|hypothetical-protein
MLDGRSRVTVVGGRRRADLALPSEAPIAEYSAALATLCEPGHRGALPAVWSLAVAGAEPLPLTASLGGAGVVDGQVLYLRDIGRDPGGQPVLTDLDELIAGEAERQRARDWPRPLVLLCFGLVWLVTAALLVPGLAGTAPVAAATVLVVVGLLLPATGWALAQQRIPVPAALCVLTSLAAVPCLAVAGALLAGVIAGNAFGWSGALVGATVAVLLSLAATPEALVAVLGLEIATAMLVSVLLVAISADGLRSAAATAVVALAAIGLARRTSALAAVWSQQRPAAGGEPATPAAHPPPPADALLARSRRLLSVLLAGPACALLVALPVLALSGTGYGLAMAGTGAVALLVRARQAGFGNEFVPLGVAGLAGLFGALVGLSRLVWPGGTEVTVVLLGAGLSLVATALITLAHGGEEAAELPPGFPPGAGRPTRRFVDLVGAGCATATVVLALGVFGVFTELAGMGRSMIGG
>NZ_CP022961.1|WP_157756796.1|3700417_3701806_+|DUF2079-domain-containing-protein
MKQTKMQTSAYDLGIFTQVVESYSRLRLPISDIKGPGYDILGDHFSPILVLVAPIYRVFPDPITLLVVQSALLAISGVPITNLAIDRCGRPWGILIGIAYGLSFGIQQAASFDFHEVAFAVPLIVVCMTFLARKRWLAAALSSLPLFLVKEDQALIVLAVGAYIFFRGPRRLGAALSIAALVVGATTVFLVIPAFNQDHTYAYLSAAGPTNHGVLTGLYLPPEKIGLLVALTAPTIFLSLASPMVLMVMPSLILRLWATNPGYWATDLHYNCVLMPILFVAFLDALHNLSSRPSVLKTRVVEFVHTSGITRRIPRSKELQWQSLTRAFSACGVLAVAVATTLTSHPLRCLIQPGFWRVEPDLADARATLETIPQGAEVSAANKLAPQLVTHHTVLMFPDEPTADIHPEWVAVKAVPDDWPVPAADQLAAIQRLPSLGYVEFARGGGVVVYRHSLDSGTRPDN
>NZ_CP022961.1|WP_095565545.1|3699342_3699894_+|sigma-70-family-RNA-polymerase-sigma-factor
MILTTAGDVRPYRTATRPRSAEDRLGELHALFRRQLLGYVGKAMCGDRAAAEDVVQETFTRAWRHLRQHDDVDVAELRPWLYTVARRLVIDVLRARRARPTEVAVTDLAAVAVSDGDLGRLVRAEAVREALRSLSAEHRTVLIELYFHDRSPAEIAELLGIPVGTVRSRSHYAKQALRAYLAD
>NZ_CP022961.1|WP_095565544.1|3696309_3699270_-|AAA-family-ATPase
MLPAADAGSRTPWRARSAYATGVGGRLTVGRDAELALLAGALDELSAGQGGTVWIEGDAGLGKSHLLAEVAELVERAAPGDCAVLTGYADQLTESFPLRVVADSLGVFGWSTDPARVPIARLLAGRATDGVRYADPVLAATELLLELAERLCAERPHVLVLEDVQWADAASLTLAERLAGMTDQLPLLILVTTRPVPIEPGSPRAALRAAAGARLRLEPLGPADVACLVRQELAAEPGPLLTALLAAAGGSPLYVREILHAARGGRLVPVAGGRVDLGAAEPVPRSLADALLRRLGVLSPEQLHAVRLGAALGNEFPVEDLDLVLGPGESSARAVGEGAGRGALAAAGAAGAVEVSRGYARFRHELIRQALLSQIPAAVRGGLHDHIARTLAAAGRPELRVASHLTAAPDPLQTWARDWLAVRPESTLYTAPAAYLELLRRAIRAAAATDACWLPLHHRLIVVAFWTGRDDLVVEVGPSVLAATADPGESARLRIKVMRSFARLGRFDEAVATVAPAIERPDTPPRWRARLSAWSANALAFLGRVEEARTQGRAALEQAEGLGDALGVAYAHSALAVVAEADQQPAHLEAGMAALGNDPESLDLRLQLAGNRAARLGALGSPEAPTAFEELLITAERVGTYRASTVRAHAADYHFDRGHWDEALLHVAQLGPAALAHPAFAYLHGMRAVIAYRRGEPERAREHLRAAGVTDGEPDRITGPTGAYLLEAVALRAEVAGDLPQALRIRCGYLDLPAGSRRNSRAFEAMFLVRLAQVLGDDRVARAAAEAVADSGGRATRDVRLAALTCRAMVEADPDALLACAADFASGGWSLCAAMALEEAAVHLAEAGEPGRARGCFNQAIDRYLEHGAAWDVRRAGARLRRYGIRRGERAAPRAARHGWAALTATELSIARLVAQGLTNADVARTMMLSRNTVQTHVSGALRKLDCRSRTALARLVALRDEAGLRDDAGLRGVAAEAGGPGDVQA
>NZ_CP022961.1|WP_095565555.1|3715041_3715335_-|WXG100-family-type-VII-secretion-target
MAEFRVDLAALAEAIGKVSGERTTISGGISSLKTTFTNVESHWQGPAATSFGTLVTNFNNATDTLMSLLDEAIGRMRTAHGNYAATEQTNTRNYTVL
>NZ_CP022961.1|WP_157756798.1|3715434_3717153_-|hypothetical-protein
MDVRAVDMFVQFTIGVPLHGLVAPLELVARESYAAPPARHLRDGLDFAGALALRYLSCVLGREVPRFALRFLSDVAGLDELRGYLAVVYTQVVAVLDHGTRPRQTRWISKNYTAVAARTSLSGMRAGLPDDARRYLSEDHDNISAMLLAAFRRAVGVELTDAELLDLPLFNPAAGTVSTYLRSALMPPGPGNPRVNQADALDVGANMLDLDDNGGRLDVPQAVLEVRHFHAPGLDQTRLGRHLATFHRLIRIENDRPAARAQQPSALRGRVLAQIARSAPRVPVLPVIDPLRTALIETPELAACWLNGDAHRRHTRMNDEAGLSLLELVAAAMAGEDFVPLLRGGAQVAASYAARLNWVSGQAGDSTGGILAESRDRWSRVAWSLDQYGSALIGRNSEVPSSLELSEGDPNRLTPEQTATLGALNLHARWTAPDGDCWFSAVLAAARDVESPSPEIARLALLDPTGLRRYLSAQIDRNPRIEQMLRTAATSPDDYARFREDLLTPGQWAHHLFDYLLAHAGELLGVVIHVHGRSPSAPPPAGPTVLHLVLGINHYLPALRNPPPDGKPQDGR
>NZ_CP022961.1|WP_157756799.1|3721918_3722863_-|hypothetical-protein
MVNLEHHATMLIRRHHLGLTDDESIIDRHPTRFPDRRRAATLSAAEQVAEFLGGRDALHGVMEALRDGGTPGAVGAARRLGSGLGSGPGDAEAAGAEPEPVGAEPDPAGLGDPGLAMRLAAYGRQVAETERMTWFDALLRSAAEDDASALPGQNAPALRRHLSDALAADDQASWQRLINPSTLHDNRRIFVEQGRLADPGSLTELLAMAPRLLGVRVVVIGRDGGETVSGPPEGTTFHLVRPDPRNTGTTRPSVARTCRPRSRRPRCVSTNFRTSPSTSAGRLTSSSRVMARTDWTTPPPSCATRCTAASETPR
>NZ_CP022961.1|WP_095565557.1|3723734_3725246_-|hypothetical-protein
MTFRVSAALRKMAGRPLNNAVLALGDRAFRRTRAVVREGDGVLSLKIPRAISEASPFSGPAPLPNMFPVPGLPGDTYVTAAFLDGALPAAERVLRALLGPQADSAEFRTSLSLPMLLTRNQLANHLPRAIGGRKLTLAENLIVPGHSSDRVTLTLAGELTDLHVVAPLSGTGTGRYAKDLSSTSTSGTAERWRPILSGGVADGGPMRVLDRDNPSAPYGSHHGDGSTGFTRQTSANQTGGIANNPRREQHVKQQGPVYLIRVQGRFTLAGTLTRHHLLSPREEIGSATSAPVTGEVYLEMFAEDVAALWTAIEKADAVVGTADPGSWPSLDRDVPRLDLDARMARMAGTAGMAAAQIRQRLALDLLAEIGAGTGLILSADARPRPAAAPAAAPGAAPAAALGAAPAEPGSTAAARRSPAVRPPPRPCCPARRRSTWAGWPACCPRQVSGSRRSRRTPRGARYCTGSSRRTRPTGTPPDGSIPARIPAPGRGPAGRPSSTSTGT
>NZ_CP022961.1|WP_095565558.1|3726302_3729839_-|hypothetical-protein
MLAGLATAGAPAPALTPELVARSVAEIFGLRVVLIEPDAAIEVLPADAPEPTNLPAVHLVVDHRGHVLPTVLSETAAGRVLTPAGDDLPDDLRDSDPDPAGAEPRPDAVRIGSGGGAGDDETATEPAAPPPPPDVTTPPTGNPATHPAAGSPAGATPPGGTPPVASPPPPAAVDPMLVGIGLPKSGLPQMPQLVEAVRGFAQRHNVALDAAAAAALPARLLANYRAVTADGLIVPVGDLDLLIRLEASDLREVPSAVTPDGPSGEVISNEVIQGTFRTGGHSESTAQQAGALRLNAAFTASLGVGPGLLNVARLGLSAGGTANSVTRTSSAGLDAETGHVEDTRGQSTLYSLQPRWSYGWIDRSTPVGTTDPERLPQTADERLYLWIPDHYVQPAPTDVVRASDAPGRRHLPETFFASGVTRLPELYRQILAELARTMPPAEVAEIRHELAVKVWNLDTHLDTAVNDASGYRFNLSNRGRAVATVTISAELTAVPTRFGTTSRIAHLEKVRTQISGYGTGVGLTNESAVRGSLEFGLLPVPAVSLGARIYAAWSATNSEGASANRIGLWVLVSRYTGHTVGYRTDLSLTARVATRAAPESVPEPTPGVNARALLRVPEPAAFEHGFPVDREALLGPPATGDTVPFQSDAVRRDGPAYPVWDVGLPHHVRLGHGIGQGLARVDRDLIARLRNAVERSLRQHDFLPRDPDRPFLANRPPRPGRGRRLGRRAGRTQKLRNAELLDRMISGDGLDSHYDQLHQDGVSFVLRRPHEGARTARITIRAVPVVDLADDLRDPETNNSIYFVRRTGEYHTVNLGMGLDIAGQSAGGGQRISVGAGVAAHAAGLQNLAAGLGYVRAMGATDAVATVINRPELLEYPGDVDEYRIPSRYTVTIEYGDAGSAAPTEIRETGAATVHLIPYFNSAPQPATDPSPAPEPQLPAAPELAPATDPRVLDRAVVHYLDATGLQAAARQVLPEFTGADRSSDQQIVNFTSRTSVAAHFKEMLENRYSTDGLFVGGAAYDRYGSLRLGVRRLGPRGSWAPPRQVRPRPDQARAGAGRAEHHPVGGDHGQHDRPGRRRQPGCGGPARARRRGGGQPGLVHLAHEGDAADRREGVPGAELPAGLRVQRPLRARGGRLDRGTGEGAARLPPYPHGRPDRRADRRLPALRAGRAGRLRSR
>NZ_CP022961.1|WP_095565559.1|3729793_3737527_-|hypothetical-protein
MPTVNPNHHATPEFPDPALLDALADAWLQMAEDLRALSGVVGTSLNYVRWTGDARNAALRTAADVANEISTTAAGAQEMGEKLQSYAAHVRSAIAQHEAAFIAEMIGLGLTVITFGLIGPISAFTTSIVTAIREFGVIVNTLAFSMPELASFANLVNFGVNIARVTVPMTVSTVVTTVDTITPNLIADRIVGLPPRVDPSGLVVAGVLGLFGGLGMAETPLPNRLRSDPLGWNHAVDDIAALRTNHGLTSGVVDPIVLNTGVRNVIDVVPPPNRLRGASSSSDVEPPVLARPDTPMPTTNPRTVSTRPDDVAGVPPPTAPRTVSARPDDAAGAPPPTAPRTTAETAAPPGTHTGRGQPVTDPAVVAETRGWAVSAAAARDQPPPPGSATRPATLADLPPGLDGTPNRGFQVGEPRTTLPLPRPGAPRDLTALAETWRGRGVPEDVILEQLGRLRAAQPPSAQPPSAQPSSAQPPSAQPSAAQPPATGGTFRPGGAPVSAEEVALAREAAARTLRAVQEPPPGSAARPATVSDLPPGGAVSERSFQVSAGRNPIRGLPSNVPRPAADILASEPVRLARLAHFEPPTDPPTPAGVRPEPPAASAPVGVRPEPPGASAPVGVRPEPPGASAPVGVRPEPPGASAPVGVRPEPPGASAPAGVRPEPPAAPATPRPVRPEPGGGTTPFPGRGQRLDGGPVTGGEGRSTTPAGELIPRPERPPGARPADGSSGGRPAPEPPGARPAPEPPGGHPPAARPPGGDRPDPPAAGGSGPARPVGGSRGGLGVRGGGGATGTELVPRPPREPATAVTRPGPDGVEPPPAERPPATATATTATETAAPATTAGTATTARPVTRTATTGTPTDTGIGRTAARPAPAETPTHAGTGGTTGRPAPAGTTPPPAGPHRTGPERIGPHRIGPERIGPERPGAGPTEVRAGGEAPPVQREFEAADTAYRQRLADAGLPVRALTVEQFIHEVRTGVPTPVRPAAAGGEPQGPVRGPAGQAAVDRAALAPPPARPDPPEVGQRRLTVDERAQVGLARWDAARGPGSGAAGPTPAQVRETVERNVANWRAQAEAARAAEAAELQRISAGLDPHLRATLRDGAIVLHHGPAPAESVRGGSAPADSVRGGSAPADQVRGGSNRRTHVVVHRSVEDVAAVGRFLRGLPADYRARPVTVALDPADGPLPAATLQDLADRLLDGVAPRAALVVPARTIADPTGHDPRIEAVDAANQPTFPEFAERFYVHPATGPAPTRTPFGLAPGGVPGSYQLRDGWEIRQTPGGLHVRPGTAPPDPPVRPPGRGPVVQVGLPGVEVPYAVRLQLHRILAGQPDWHRPRLVEHGTDPTVAPLAAGLAPGHQIARVPGGVVLFRGPAPAPEALGAGLRPVPGAGLAVVVDRSVRDPRVIQRFLRGLPRLGGAVAVSMDPTGPDLRPGRAQRLASWLGRGSRNPVDLLLPRRAFAAVPRLGGRVVGLADDGRETLPALAPRVLLRAAEAPVPAGLHPVPRRPGLFAVAAVPGWYLRETSRGAWLHPAAEPAPPAPPADPAEPYVLLGGAGVTATPQVRDALYEALAALAPAGVRVFAELEPARAAQQGGEVRVWTVPGGRVLYRGEAPDPAVVAELSGLARPDRLTVAVDRSVTRSAQVRGELAAIRAVDRRPITVRLAPGAPPRPVDRLARLADRLLRGIADAALRVPVRALAGPVEPGSGAVPVDRSGRPTLPALAEAYDLRPGPAGTPADRIDLGHGWWLETVDGRTVWAHPGHDRDTLADLSATLPAPTPSALAPSALAPPAPTPPAPTPSALAPPAPTLSGSGRPAAGAAGAVRVAIDGRVEVPAPVRARLADLAAGTDTVVLPGTATGPRTDQPPPGILPVPGVAGLYALPGSPDEATRAVQRAFAAGADLPGQVAGAATMLVVDGPVDAAAGTVRTPYGPLSASGLAQVLLMLPGGVPDFVVFTAPAARVAVGDRPALHAAVAELVPGSVFAPNAQVGIGPGWRLVAGDGEPSPGTAEPPTGEPSTGEPAAESGSWRMLGGRGRTARSIGAVLDLPTPPAVPDPAPTGSRGDRPAPGRSAASPPASGSSASGSSGSDLFDRAPGGSGSTDTAPTTVDPQNQPELPDRPEPLDRPEPLDRPEPLDRPEPLDRPDPVRDGRPAPAAWTGWLAPPHEQRLDPAVGKTLAELGLHALAPEPDMGFFQVVAAQAAVYAGGDAVDLAAVAPAKVWTDLVGQVLRADRSERAPDWPLLRLAAPDPAAVAAVDAWIAGGLPLDAIPLPLTSGLPEGAEKVEAVLTAVAVTLGVDIQLVRRDGRVSRFAPRPPDVPPDAPAGAAPGVPARPLVTLATGPDGVLGTVPARAVPALLAAGGPARVVRPVGGPAPAGLPADEDALRDAAAFLTGVSGLTDLRLPPIDELATGLHRAVRHGVAELRPGPGLGATINRVRAAVAAAAKPVPLTAATPAWIEPEWAPPPTGAADPYPLSPFQRDRLGGAGRAAVAVPAGPDAFFAGLHGAGRYEQPRLLGLTNWTPADLRAMFAALLQADLAAAGDTWPLLNFATPSSSPRTAARSCRCWPGWPRPAPRPPP
>NZ_CP022961.1|WP_157756800.1|3737555_3738002_-|hypothetical-protein
MPVPANYNDHTMLIKVDPTTVWGYADTDMPAQAKVIGDALGRIHDTWEGLALGWAGTTAQEAQDFSSRWNAALTGLFGSREHPENGALPRIAKAVGMAALNYAETEDTVLQMFADFSAGLQGTGSSQPPVRDHNEGPITENTPSWTNP
>NZ_CP022961.1|WP_095565561.1|3738235_3739027_+|hypothetical-protein
MPATRNRQQQPPEQSKGSEQTSAVPPNGGAWEQDDGGTWTWHRGATPEPELVSQWGYQALTDIRRDPLGNRNYGAWTPQHGGGWHWDWGRKPSQTLVDRYGEDVLTDPDHLPGHSHSATDNNQPPPPDVNPPTLADSWHGVVPDVTGAVPRPPDTGDAPTVTTPPVHQAYTVSPGAIRQAEQVVLSNIDIQLFAYDALKSKVAASKGEFTYMARERETLINNQDRLLLQVGDTLELAGQFVRALNNAAQLYARADLDSFVPET
>NZ_CP022961.1|WP_095565562.1|3742206_3743103_+|universal-stress-protein
MTTKLTGPVVVGIDGSTIALDAVRAAARTAAGRHRPLRVVHAFIWPIINVPTGPISGGVADGGLRRQAERYVTEAVAEAGKVAPELDVTGAVVDGAPVPVLLGESRDAALLVLGNRGLGGFAGLVLGSVTVQVSAQARCPVLVVRGEPRADGPVVVGVDGSAGSAQAAGYAFEEAAWRGVPLVAVHAWLEPAPAGPGDMLPLVYDPDLLAAQEERVLAESLAGFAERYPQVPVRRRLVRGSAAGALVRESESAQLVVVGARGRGALAGLLLGSVSHAVLHHAHAPVAVVRHTPRQPRA
>NZ_CP022961.1|WP_157756801.1|3743172_3743826_-|hypothetical-protein
MSRRSARIRVLTMLTAGLAAAAVAAVVVSAVSAGGRDPDRGRDPGHGRGVRVDTASGLLVTGRSALRMCVENGGGAQAGTRTGLRAGLDLVRADPNWAGAYGRVRVDPADALAFGCPAPRLPQRAGRAAVAGPGLTATPSPYRVWVYVLDGADADRILGPGQPSGLATAELVQEANTAWPVSTALLIRRDRLGDPRSVAEGLRAALGLVEAGTAPAA

Crispr_ID: NZ_CP022961_16

• CRISPR_ID: NZ_CP022961_16
• CRISPR_location: 3746686-3746875
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP022961_16

Consensus_repeat	Method
GTTGCGATCCTCACCCGGGCCGAAGTCCGGGTGCAGCG	CRISPRCasFinder

spacers of NZ_CP022961_16

>16.1|3746724|38|NZ_CP022961|CRISPRCasFinder
ACGTGCGAGCGCTGGAGGCGGTCACCGGCCTGCCGATC
>16.2|3746800|38|NZ_CP022961|CRISPRCasFinder
TCCTCATCCGTCGGGTTGGGCCGGTCGGGGCGGAGTGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_16

CRISPR arrays

The CRISPR arrays of NZ_CP022961_16

>merge|NZ_CP022961|16|3746686-3746875|CRISPRCasFinder
GTTGCAGTCCTCGCCCGCTCCGGGGAACGGGCGCGGCTACGTGCGAGCGCTGGAGGCGGTCACCGGCCTGCCGATCGTTGCGATCCTCACCCGGGCCGAAGTCCGGGTGCAGCGTCCTCATCCGTCGGGTTGGGCCGGTCGGGGCGGAGTGGGTTGCGATCCTCACCCGGGCCGAAGTCCGGGTGCAGCG

>NZ_CP022961|16|16|3746686-3746875|CRISPRCasFinder
GTTGCAGTCCTCGCCCGCTCCGGGGAACGGGCGCGGCT	ACGTGCGAGCGCTGGAGGCGGTCACCGGCCTGCCGATC
GTTGCGATCCTCACCCGGGCCGAAGTCCGGGTGCAGCG	TCCTCATCCGTCGGGTTGGGCCGGTCGGGGCGGAGTGG
GTTGCGATCCTCACCCGGGCCGAAGTCCGGGTGCAGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565568.1|3752585_3753950_+|amino-acid-permease	unknown	unknown	gnl|CDD|129987
NZ_CP022961.1|WP_095565573.1|3757825_3758659_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|225136
NZ_CP022961.1|WP_095567899.1|3756051_3756846_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|223979
NZ_CP022961.1|WP_095567898.1|3745212_3746238_-|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP022961.1|WP_095565558.1|3726302_3729839_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP022961.1|WP_095565572.1|3757245_3757683_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197666
NZ_CP022961.1|WP_157756801.1|3743172_3743826_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565562.1|3742206_3743103_+|universal-stress-protein	unknown	unknown	gnl|CDD|366180
NZ_CP022961.1|WP_157756800.1|3737555_3738002_-|hypothetical-protein	unknown	unknown	gnl|CDD|227179
NZ_CP022961.1|WP_095565564.1|3743841_3744564_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565561.1|3738235_3739027_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565571.1|3756823_3757234_-|VOC-family-protein	unknown	unknown	gnl|CDD|319924
NZ_CP022961.1|WP_095565559.1|3729793_3737527_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP022961.1|WP_095565566.1|3747235_3750331_-|hypothetical-protein	unknown	unknown	gnl|CDD|224389
NZ_CP022961.1|WP_095567900.1|3758658_3759324_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP022961.1|WP_095565557.1|3723734_3725246_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP022961.1|WP_095565567.1|3750543_3752364_+|coagulation-factor-5/8-type-domain-containing-protein	unknown	unknown	gnl|CDD|185753
NZ_CP022961.1|WP_157756799.1|3721918_3722863_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565569.1|3754130_3754838_+|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl|CDD|377432
NZ_CP022961.1|WP_095565570.1|3754834_3756010_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|273670

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565568.1|3752585_3753950_+|amino-acid-permease	gnl|CDD|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.16033e-52
NZ_CP022961.1|WP_095567899.1|3756051_3756846_+|NUDIX-hydrolase	gnl|CDD|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	2.60261e-21
NZ_CP022961.1|WP_095567898.1|3745212_3746238_-|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.49194e-77
NZ_CP022961.1|WP_095565558.1|3726302_3729839_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000110541
NZ_CP022961.1|WP_095565572.1|3757245_3757683_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	2.58419e-27
NZ_CP022961.1|WP_095565567.1|3750543_3752364_+|coagulation-factor-5/8-type-domain-containing-protein	gnl|CDD|185753	cd09214, GH64-like, glycosyl hydrolase 64 family. This family is represented by the laminaripentaose-producing, beta-1,3-glucanase (LPHase) of Streptomyces matensis and related bacterial and ascomycete proteins. LPHase is a member of glycoside hydrolase family 64 (GH64), it is an inverting enzyme involved in the cleavage of long-chain polysaccharide beta-1,3-glucans, into specific pentasaccharide oligomers. LPHase is a two-domain crescent fold structure: one domain is composed of 10 beta-strands, eight coming from the N-terminus of the protein and two from the C-terminal region, and the protein has a second inserted domain; this cd includes both domains. This protein has an electronegative, substrate-binding cleft, and conserved Glu and Asp residues involved in the cleavage of the beta-1,3-glucan, laminarin, a plant and fungal cell wall component. Among bacteria, many beta-1,3-glucanases are implicated in fungal cell wall degradation. Also included in this family is GluB , the beta-1,3-glucanase B from Lysobacter enzymogenes Strain N4-7. Recombinant GluB demonstrated higher relative activity toward the branched-chain beta-1,3 glucan substrate zymosan A than toward linear beta-1,3 glucan substrates. Sometimes these two domains are found associated with other domains such as in the Catenulispora acidiphila DSM 44928 carbohydrate binding family 6 protein in which they are positioned N-terminal of a carbohydrate binding module, family 6 (CBM_6) domain. In the Cellulosimicrobium cellulans, glucan endo-1,3-beta-glucosidase, they are positioned N-terminal of a RICIN, carbohydrate-binding domain, and in the Salinispora tropica CNB-440, coagulation factor 5/8 C-terminal domain (FA58C) protein, they are positioned C-terminal of two FA58C domains which are proposed to function as cell surface-attached, carbohydrate-binding domain. This FA58C-containing protein has an internal peptide deletion (of approx. 44 residues) in the LPHase domain II.	1.35972e-98
NZ_CP022961.1|WP_095565562.1|3742206_3743103_+|universal-stress-protein	gnl|CDD|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.72051e-26
NZ_CP022961.1|WP_157756800.1|3737555_3738002_-|hypothetical-protein	gnl|CDD|227179	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown].	0.000119492
NZ_CP022961.1|WP_095565571.1|3756823_3757234_-|VOC-family-protein	gnl|CDD|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.97547e-37
NZ_CP022961.1|WP_095565559.1|3729793_3737527_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.24412e-16
NZ_CP022961.1|WP_095565557.1|3723734_3725246_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	4.93319e-07
NZ_CP022961.1|WP_095567900.1|3758658_3759324_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.73583e-11
NZ_CP022961.1|WP_095565566.1|3747235_3750331_-|hypothetical-protein	gnl|CDD|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	3.4351e-37
NZ_CP022961.1|WP_095565573.1|3757825_3758659_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	9.57266e-28
NZ_CP022961.1|WP_095565569.1|3754130_3754838_+|nicotinamide-mononucleotide-transporter	gnl|CDD|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	2.55853e-46
NZ_CP022961.1|WP_095565570.1|3754834_3756010_+|AAA-family-ATPase	gnl|CDD|273670	TIGR01526, nadR_NMN_Atrans, nicotinamide-nucleotide adenylyltransferase, NadR type. The NadR protein of E. coli and closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal to the region covered by this model, is a DNA-binding helix-turn-helix domain (pfam01381) responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologs in Mycobacterium tuberculosis, Haemophilus influenzae, and others appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this model share that activity.	3.77426e-42

Protein sequences

>NZ_CP022961.1|WP_095567898.1|3745212_3746238_-|LacI-family-transcriptional-regulator
MTRPSPKRVTISDIARRAGVSVGAVSFALNGRKGVSEETRQRVLRLAEELGWAPTSAARSLAEAKTDTFGLVLARDPRTLGVESFYMQFIAGLEAELTRRSYGLLLQVAASPRDELATLKKWRNARRVDGVILVDLAVDDPRVELSVQPNALPVVAVGDPGVAGGLTSVWTDDAESTRQAVRHLAGLGHRRIARVSGLDFLAHTRIRNDAFVAEMTGLGLDPLLLRTDYTPESGARATRAALTGSGRPTALVYDNDVMAVAGLGVALELGFGVPADVSIVAWDDSPFCAYTYPTLSALSHDVVAFGSHVARRLFDVLAGAEPGAFLDSTPRLITRGSTGPA
>NZ_CP022961.1|WP_095565564.1|3743841_3744564_-|hypothetical-protein
MSKPHSDERLPAWVPVIWVAVLLAALLVPADPARAAQPNPSSTKHLHNMHYNSVGSSAGTYDEQFCIESHDTSKVSNSAGRAFVNETLTQMGSGRVWDGLGDWRIDLWPTASNCTSYSASTRAGIEIEVHYGWDWSGICGGTTGYYNCVVHDNPVWDAAHNHYDSQWAYVYLVFSSGGRLDTTGRAFINHEFGHVFGLADDSNCSPPSLMSSTIVGYNCSTWTNWYPSPADFQWVLGVQG
>NZ_CP022961.1|WP_157756801.1|3743172_3743826_-|hypothetical-protein
MSRRSARIRVLTMLTAGLAAAAVAAVVVSAVSAGGRDPDRGRDPGHGRGVRVDTASGLLVTGRSALRMCVENGGGAQAGTRTGLRAGLDLVRADPNWAGAYGRVRVDPADALAFGCPAPRLPQRAGRAAVAGPGLTATPSPYRVWVYVLDGADADRILGPGQPSGLATAELVQEANTAWPVSTALLIRRDRLGDPRSVAEGLRAALGLVEAGTAPAA
>NZ_CP022961.1|WP_095565562.1|3742206_3743103_+|universal-stress-protein
MTTKLTGPVVVGIDGSTIALDAVRAAARTAAGRHRPLRVVHAFIWPIINVPTGPISGGVADGGLRRQAERYVTEAVAEAGKVAPELDVTGAVVDGAPVPVLLGESRDAALLVLGNRGLGGFAGLVLGSVTVQVSAQARCPVLVVRGEPRADGPVVVGVDGSAGSAQAAGYAFEEAAWRGVPLVAVHAWLEPAPAGPGDMLPLVYDPDLLAAQEERVLAESLAGFAERYPQVPVRRRLVRGSAAGALVRESESAQLVVVGARGRGALAGLLLGSVSHAVLHHAHAPVAVVRHTPRQPRA
>NZ_CP022961.1|WP_095565561.1|3738235_3739027_+|hypothetical-protein
MPATRNRQQQPPEQSKGSEQTSAVPPNGGAWEQDDGGTWTWHRGATPEPELVSQWGYQALTDIRRDPLGNRNYGAWTPQHGGGWHWDWGRKPSQTLVDRYGEDVLTDPDHLPGHSHSATDNNQPPPPDVNPPTLADSWHGVVPDVTGAVPRPPDTGDAPTVTTPPVHQAYTVSPGAIRQAEQVVLSNIDIQLFAYDALKSKVAASKGEFTYMARERETLINNQDRLLLQVGDTLELAGQFVRALNNAAQLYARADLDSFVPET
>NZ_CP022961.1|WP_157756800.1|3737555_3738002_-|hypothetical-protein
MPVPANYNDHTMLIKVDPTTVWGYADTDMPAQAKVIGDALGRIHDTWEGLALGWAGTTAQEAQDFSSRWNAALTGLFGSREHPENGALPRIAKAVGMAALNYAETEDTVLQMFADFSAGLQGTGSSQPPVRDHNEGPITENTPSWTNP
>NZ_CP022961.1|WP_095565559.1|3729793_3737527_-|hypothetical-protein
MPTVNPNHHATPEFPDPALLDALADAWLQMAEDLRALSGVVGTSLNYVRWTGDARNAALRTAADVANEISTTAAGAQEMGEKLQSYAAHVRSAIAQHEAAFIAEMIGLGLTVITFGLIGPISAFTTSIVTAIREFGVIVNTLAFSMPELASFANLVNFGVNIARVTVPMTVSTVVTTVDTITPNLIADRIVGLPPRVDPSGLVVAGVLGLFGGLGMAETPLPNRLRSDPLGWNHAVDDIAALRTNHGLTSGVVDPIVLNTGVRNVIDVVPPPNRLRGASSSSDVEPPVLARPDTPMPTTNPRTVSTRPDDVAGVPPPTAPRTVSARPDDAAGAPPPTAPRTTAETAAPPGTHTGRGQPVTDPAVVAETRGWAVSAAAARDQPPPPGSATRPATLADLPPGLDGTPNRGFQVGEPRTTLPLPRPGAPRDLTALAETWRGRGVPEDVILEQLGRLRAAQPPSAQPPSAQPSSAQPPSAQPSAAQPPATGGTFRPGGAPVSAEEVALAREAAARTLRAVQEPPPGSAARPATVSDLPPGGAVSERSFQVSAGRNPIRGLPSNVPRPAADILASEPVRLARLAHFEPPTDPPTPAGVRPEPPAASAPVGVRPEPPGASAPVGVRPEPPGASAPVGVRPEPPGASAPVGVRPEPPGASAPAGVRPEPPAAPATPRPVRPEPGGGTTPFPGRGQRLDGGPVTGGEGRSTTPAGELIPRPERPPGARPADGSSGGRPAPEPPGARPAPEPPGGHPPAARPPGGDRPDPPAAGGSGPARPVGGSRGGLGVRGGGGATGTELVPRPPREPATAVTRPGPDGVEPPPAERPPATATATTATETAAPATTAGTATTARPVTRTATTGTPTDTGIGRTAARPAPAETPTHAGTGGTTGRPAPAGTTPPPAGPHRTGPERIGPHRIGPERIGPERPGAGPTEVRAGGEAPPVQREFEAADTAYRQRLADAGLPVRALTVEQFIHEVRTGVPTPVRPAAAGGEPQGPVRGPAGQAAVDRAALAPPPARPDPPEVGQRRLTVDERAQVGLARWDAARGPGSGAAGPTPAQVRETVERNVANWRAQAEAARAAEAAELQRISAGLDPHLRATLRDGAIVLHHGPAPAESVRGGSAPADSVRGGSAPADQVRGGSNRRTHVVVHRSVEDVAAVGRFLRGLPADYRARPVTVALDPADGPLPAATLQDLADRLLDGVAPRAALVVPARTIADPTGHDPRIEAVDAANQPTFPEFAERFYVHPATGPAPTRTPFGLAPGGVPGSYQLRDGWEIRQTPGGLHVRPGTAPPDPPVRPPGRGPVVQVGLPGVEVPYAVRLQLHRILAGQPDWHRPRLVEHGTDPTVAPLAAGLAPGHQIARVPGGVVLFRGPAPAPEALGAGLRPVPGAGLAVVVDRSVRDPRVIQRFLRGLPRLGGAVAVSMDPTGPDLRPGRAQRLASWLGRGSRNPVDLLLPRRAFAAVPRLGGRVVGLADDGRETLPALAPRVLLRAAEAPVPAGLHPVPRRPGLFAVAAVPGWYLRETSRGAWLHPAAEPAPPAPPADPAEPYVLLGGAGVTATPQVRDALYEALAALAPAGVRVFAELEPARAAQQGGEVRVWTVPGGRVLYRGEAPDPAVVAELSGLARPDRLTVAVDRSVTRSAQVRGELAAIRAVDRRPITVRLAPGAPPRPVDRLARLADRLLRGIADAALRVPVRALAGPVEPGSGAVPVDRSGRPTLPALAEAYDLRPGPAGTPADRIDLGHGWWLETVDGRTVWAHPGHDRDTLADLSATLPAPTPSALAPSALAPPAPTPPAPTPSALAPPAPTLSGSGRPAAGAAGAVRVAIDGRVEVPAPVRARLADLAAGTDTVVLPGTATGPRTDQPPPGILPVPGVAGLYALPGSPDEATRAVQRAFAAGADLPGQVAGAATMLVVDGPVDAAAGTVRTPYGPLSASGLAQVLLMLPGGVPDFVVFTAPAARVAVGDRPALHAAVAELVPGSVFAPNAQVGIGPGWRLVAGDGEPSPGTAEPPTGEPSTGEPAAESGSWRMLGGRGRTARSIGAVLDLPTPPAVPDPAPTGSRGDRPAPGRSAASPPASGSSASGSSGSDLFDRAPGGSGSTDTAPTTVDPQNQPELPDRPEPLDRPEPLDRPEPLDRPEPLDRPDPVRDGRPAPAAWTGWLAPPHEQRLDPAVGKTLAELGLHALAPEPDMGFFQVVAAQAAVYAGGDAVDLAAVAPAKVWTDLVGQVLRADRSERAPDWPLLRLAAPDPAAVAAVDAWIAGGLPLDAIPLPLTSGLPEGAEKVEAVLTAVAVTLGVDIQLVRRDGRVSRFAPRPPDVPPDAPAGAAPGVPARPLVTLATGPDGVLGTVPARAVPALLAAGGPARVVRPVGGPAPAGLPADEDALRDAAAFLTGVSGLTDLRLPPIDELATGLHRAVRHGVAELRPGPGLGATINRVRAAVAAAAKPVPLTAATPAWIEPEWAPPPTGAADPYPLSPFQRDRLGGAGRAAVAVPAGPDAFFAGLHGAGRYEQPRLLGLTNWTPADLRAMFAALLQADLAAAGDTWPLLNFATPSSSPRTAARSCRCWPGWPRPAPRPPP
>NZ_CP022961.1|WP_095565558.1|3726302_3729839_-|hypothetical-protein
MLAGLATAGAPAPALTPELVARSVAEIFGLRVVLIEPDAAIEVLPADAPEPTNLPAVHLVVDHRGHVLPTVLSETAAGRVLTPAGDDLPDDLRDSDPDPAGAEPRPDAVRIGSGGGAGDDETATEPAAPPPPPDVTTPPTGNPATHPAAGSPAGATPPGGTPPVASPPPPAAVDPMLVGIGLPKSGLPQMPQLVEAVRGFAQRHNVALDAAAAAALPARLLANYRAVTADGLIVPVGDLDLLIRLEASDLREVPSAVTPDGPSGEVISNEVIQGTFRTGGHSESTAQQAGALRLNAAFTASLGVGPGLLNVARLGLSAGGTANSVTRTSSAGLDAETGHVEDTRGQSTLYSLQPRWSYGWIDRSTPVGTTDPERLPQTADERLYLWIPDHYVQPAPTDVVRASDAPGRRHLPETFFASGVTRLPELYRQILAELARTMPPAEVAEIRHELAVKVWNLDTHLDTAVNDASGYRFNLSNRGRAVATVTISAELTAVPTRFGTTSRIAHLEKVRTQISGYGTGVGLTNESAVRGSLEFGLLPVPAVSLGARIYAAWSATNSEGASANRIGLWVLVSRYTGHTVGYRTDLSLTARVATRAAPESVPEPTPGVNARALLRVPEPAAFEHGFPVDREALLGPPATGDTVPFQSDAVRRDGPAYPVWDVGLPHHVRLGHGIGQGLARVDRDLIARLRNAVERSLRQHDFLPRDPDRPFLANRPPRPGRGRRLGRRAGRTQKLRNAELLDRMISGDGLDSHYDQLHQDGVSFVLRRPHEGARTARITIRAVPVVDLADDLRDPETNNSIYFVRRTGEYHTVNLGMGLDIAGQSAGGGQRISVGAGVAAHAAGLQNLAAGLGYVRAMGATDAVATVINRPELLEYPGDVDEYRIPSRYTVTIEYGDAGSAAPTEIRETGAATVHLIPYFNSAPQPATDPSPAPEPQLPAAPELAPATDPRVLDRAVVHYLDATGLQAAARQVLPEFTGADRSSDQQIVNFTSRTSVAAHFKEMLENRYSTDGLFVGGAAYDRYGSLRLGVRRLGPRGSWAPPRQVRPRPDQARAGAGRAEHHPVGGDHGQHDRPGRRRQPGCGGPARARRRGGGQPGLVHLAHEGDAADRREGVPGAELPAGLRVQRPLRARGGRLDRGTGEGAARLPPYPHGRPDRRADRRLPALRAGRAGRLRSR
>NZ_CP022961.1|WP_095565557.1|3723734_3725246_-|hypothetical-protein
MTFRVSAALRKMAGRPLNNAVLALGDRAFRRTRAVVREGDGVLSLKIPRAISEASPFSGPAPLPNMFPVPGLPGDTYVTAAFLDGALPAAERVLRALLGPQADSAEFRTSLSLPMLLTRNQLANHLPRAIGGRKLTLAENLIVPGHSSDRVTLTLAGELTDLHVVAPLSGTGTGRYAKDLSSTSTSGTAERWRPILSGGVADGGPMRVLDRDNPSAPYGSHHGDGSTGFTRQTSANQTGGIANNPRREQHVKQQGPVYLIRVQGRFTLAGTLTRHHLLSPREEIGSATSAPVTGEVYLEMFAEDVAALWTAIEKADAVVGTADPGSWPSLDRDVPRLDLDARMARMAGTAGMAAAQIRQRLALDLLAEIGAGTGLILSADARPRPAAAPAAAPGAAPAAALGAAPAEPGSTAAARRSPAVRPPPRPCCPARRRSTWAGWPACCPRQVSGSRRSRRTPRGARYCTGSSRRTRPTGTPPDGSIPARIPAPGRGPAGRPSSTSTGT
>NZ_CP022961.1|WP_157756799.1|3721918_3722863_-|hypothetical-protein
MVNLEHHATMLIRRHHLGLTDDESIIDRHPTRFPDRRRAATLSAAEQVAEFLGGRDALHGVMEALRDGGTPGAVGAARRLGSGLGSGPGDAEAAGAEPEPVGAEPDPAGLGDPGLAMRLAAYGRQVAETERMTWFDALLRSAAEDDASALPGQNAPALRRHLSDALAADDQASWQRLINPSTLHDNRRIFVEQGRLADPGSLTELLAMAPRLLGVRVVVIGRDGGETVSGPPEGTTFHLVRPDPRNTGTTRPSVARTCRPRSRRPRCVSTNFRTSPSTSAGRLTSSSRVMARTDWTTPPPSCATRCTAASETPR
>NZ_CP022961.1|WP_095565566.1|3747235_3750331_-|hypothetical-protein
MPTPPPAPPAPPTPHQRRRSGAVYAALLALLAAYLTVPTGPAAAAGPLISQGKPTTASSSEAAGTPASAATDGDTGTRWSSAFADPQWLQVDLGATATVDQVQLVWEAAYATAFQIQTSASPSGPWATIYSTTTGTGGTQTLAVSGSGRYVRMYGTARATGYGYSLWEFRVYGTTGTTPPPSGRPISEFKKVDASSWEGGNAPAAALDGRTNTRWSSSFADPQWLRVDFGATATINRVVLNWEAAYATAYRLETSTNGTTWTTIYSTTTGAGGVEQLTVSGTGRYLRFYGTARATGYGYSLWEFQAYGTLDETASTPPMLSGPTRPPGTLNQFALSAPGDGAMITTTRRPTLTWAAVSGATRYQVWINISRTDYDFTASGNLIDLYTKVAEPTGTSYTPTWDLPDRWTYKWYITSVGGTALTSNIRRFSVYLPTLETVADGINIVAGSRDLNRNGTIEPYEDWRQPVETRVSDLLGRMTTEEKAYQMFYNAQQFPRSGWHFGPAQAQDLHTQLLASAGTRLGIPFVSAGDTIHGYQTTYPMQSALAAAKDYRLDYQLGDMQRREQLEVGTRGVLGPLAEVGTKVIYPRIQEGNGENAQVAAAQVRALVAGLQGGPELNPNSVLATVKHWPGEGAGGEALIVYDGVTIKYHMIPFRAAMEAGAVNIMPGYAGSSYLDPGGPGAGDSAPILAYLRQNLGYQGLITTDWLPSGSWVGAANAGSDVMGGADPGAEGFSMATFTANVPTSRIDDAVRRVLRLKFQLGIFEAPYGDPVNGPYRFHQPAYTALANQASREAMTLLKNDGGVLPIRLNPGDNIVVAGPRADDTTACCVWTSFFHAEYGSQTMLAAIRNRATQAGVNVYSGDGPNPKLAIVAVGETSYTHATNWPKEQPYLPADQLAVIQNFRARGIPVVVALVLPRPYVITEWRDLASAIVVTYRGGEEMGPALASLLFGDYTPSGKLPWQLPRSLDQVLRPGGTDIPADAVESWDLPYDLGATTAERNQIRASIDAGQQPATNYGNPLYPYGAGMTGF
>NZ_CP022961.1|WP_095565567.1|3750543_3752364_+|coagulation-factor-5/8-type-domain-containing-protein
MSTPASTPQVRPPRHRPASAGRRPRPHRRLLTSAAAVLALLSGSIVASTPFAAGAASPLISQGRATTASTSETPETPASAATDGDTGTRWSSAFADPQWLQVDLGATATVDQVQLVWEAAYARSFQIQVATAPGGPWTTIYSTTTGTGGTQTLAVSGSGRYVRMYGTARATAYGYSLWEFRVYGSAASAACTGNAALNRPATASSTENAASPASAAVDGNTGTRWSSAFADPQWLRVDLGSTQTLCQVVLDWEAAYARSFQIQVATAADGPWTTIYSTTTGTGGTQTLAVSGSGRYVRMYGTARATAYGYSLWEFTVRTTSGSSTPPPTTPPPTGGFWGDTGSIPAAQNVLMVKVLNRTNGQYPDSQVYWSYNGQSHSIAEQPYFDMPVNTAGRMYFHLGSPTSQYSDFIEFTVGAAQFNGNTTRVDGFALKLAMRLHSHTGTDVSVGENEATFAESRTVTFQRFSDAMPAEFKHLATIEAPYRIPSPGNTPQFQAGGQYANYFSSYASSVGLPASATEIFGCAGPLAGNPNGCAALNRHVAQLPQAQWSNPSLFYQQAPANYYAKFWHDRAINNRSYGFPYDDVADQSSFVSAANPQWLLVAVGW
>NZ_CP022961.1|WP_095565568.1|3752585_3753950_+|amino-acid-permease
MATRDPLTRSATPTTSPAHGSIGLLTCVAFAVGTMVGAGVFVLSGLAVQRAGPAAMLSFVLAGVLVLLSALSFAVVASLAPPGGSGYAYVGVALGTRLGFLTSWAFWLGGVIGVAFVLNAFGSYLHDFFVPDASALVVAVLAAVLIAGLNLGPASLIGRAETALVAVKVAILALLVVFAFVHLGRAHLTPFTPHGGGAVLTTSSLLFVAYLGFNVVTNMAGDVRRPQRTIPLAILISMALVALIYVGVVVALLAGGISSYDEASVGTAARHLIGGWGGVLIPIGALISTLSAANANTLGSSEIMVRLAADRQVPTAAGRLWHGHPAVSVLAGAAISVVLLLTGDIQTIVALGNVAAIAAMVLVNAAAVRAQRSRDGRGIALPGGPLLPALGLLTAAVQLAFIAWWQTLLGLLLVAAGLGLHALRGRHHAGHHARIVEQLGRNAGPAGRALARRR
>NZ_CP022961.1|WP_095565569.1|3754130_3754838_+|nicotinamide-mononucleotide-transporter
MLAWLAQLIAPLNAVLFRIGNDAVSWAELLGFVSGAACVWLTVRSSIHNFWVGIANCTFFLVLFATARLWADGGLQIVYIVLGIIGWWQWLHGGADRGALTVRRATPRTLAGCVGFVVVATWGLTVLLTAVHDSAPFWDALTTAISLAAQYLLNAKRVETWLFWMAADVVYIPLYAAKGLVLTAVVYTLFLGMTILGLRAWLAASTPGRTGVSAPDGTTGSGPAAAPAGGTGVPA
>NZ_CP022961.1|WP_095565570.1|3754834_3756010_+|AAA-family-ATPase
MRTYRHGLVIGKFYPPTLGHHHLIRTAAARADRVTVVCMASAVESIPLADRVDWLRAEHAADPAVTVVGVRCDAPVDLTDGTVWAAQVASMRAAVGTATDLPVDAVFTGEAYGRELADRLRADHVPVDPGRTSVPVSGTAVRADLAGGWDLLAPATRAGLATRVVLVGAESTGTTTISRLLADHYRDLGGVWARTGWVGEYGREYTELKWARDRRDQPDLALDDLRWGPEDFDAVATGQIRREEAAARAGSPLLVCDTDAFATAVWERRYLGPRARAGQPWAAGAARRAVYLVTDHDGVAWVDDGLREGDQQVRAAMTGWFTDALTRAGASWVLLTGDVGQRLALAVRTTDLLLRRAATFAPPIPETTHPGPRSRTATRGTTRTTAGPVAR
>NZ_CP022961.1|WP_095567899.1|3756051_3756846_+|NUDIX-hydrolase
MAGYDPRAFPPFALTVDLNIFTIRGGVLTVLLIRRGDHPYRGFWALPGGHVTHGRESADRAAVRELGEETGLDWATVGGHLEQVGTYTDPRRDPRIRAGLHVASVAYVALAPRLPEPTAASDAAQARYWPVEDLDLAAQRAAWEAGEPYAGDVPVLAYDHALILSDALERVRAKLEYSTLAGQFVTEPFTLADLRRVYQAVWGYAPDLANFRRKMLNVPGFLIPTDEHRPAASERGGAPPLLYRRGAARWIVPPFTRISPSTPD
>NZ_CP022961.1|WP_095565571.1|3756823_3757234_-|VOC-family-protein
MRLTLQYTFLEVDDHEAALAFYRDALGFEVRQDVAMEGARWLTVGPSDQPDLGIVLQSVGAGRSPQDARTLRELLAKGSLSGLVLQADDVDRLFERIEATGAEVLQEPMDQPYGVRDCAFRDPAGNQVRINQVSKG
>NZ_CP022961.1|WP_095565572.1|3757245_3757683_-|helix-turn-helix-transcriptional-regulator
MCHPGRVDPADLKLLRRARDLIDREYARPLDVPAMARAALMSPAHFSRQFRAVYGETPYTYLMTRRIERAKALLRRGDLSVTEVCLAVGATSLGSFSTRFTELVGESPSAYRARNHSAFSAVPGCWAKHVSRPSRIREAQVSAVR
>NZ_CP022961.1|WP_095565573.1|3757825_3758659_+|class-I-SAM-dependent-methyltransferase
MEATVNVDQARAWNGYEGEHWALHADRYDAVNSGVNRFLLEAAAPGERDRVLDVGCGTGQLTRLAAAAAPHGHAVGVDLSAPMLAVARSRAAADGLANVTFERGDAQVHPFPPGGFDAALSRFGIMFFADPVAAFGNIHTALRPGGRLAFACLTDLDGTDLGTLFAAMAPHLPRPTGPAGSGPTSFADPERIAAVLGAAGFHDVTCTHVETTQVWGRDVPDAAEFISGWGPVRHHMTLAGPAAAEHARAGLTAALADFAGPDGVRLCGTAWLVAAAA
>NZ_CP022961.1|WP_095567900.1|3758658_3759324_+|TetR/AcrR-family-transcriptional-regulator
MAPRRAGALRAEDGRIGLREHLIGAAERLIAEHGTAGLTVRAIARAAGVADGVLYNHFADKEELLAHALYAHVQAVERALGALPTPGTGTVEANLRAHLRYGLALHRAILPAFAGLLGRPAVLARFAELDGAGRPWRDRLAGYLHAERDLGRLGTDVTDARLAAAAAMLVGICHDTVLTRLLAPGGPHPAPRPAGGPGRSDAPDAALVGPVIAVLLAGIGR

Crispr_ID: NZ_CP022961_17

• CRISPR_ID: NZ_CP022961_17
• CRISPR_location: 3912276-3913291
• CRISPR_type: Unclear
• Repeat_type: NA:?
• Spacer_info: 15 spacers
• Cas_protein_info: cas6,csx19,csm3gr7,cas7,cas5,cas3,cas4,cas1,cas2

Consensus repeat of NZ_CP022961_17

Consensus_repeat	Method
GTTGCGATCCC------TCCAGGGGTGAT-GGGCGAC	PILER-CR
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CRISPRCasFinder
GTCGCCCATCACCCCTGGAGGGATCGCAACN	CRT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CRISPRCasFinder

spacers of NZ_CP022961_17

>17.1|3912306|35|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GTGGGGCGCTGCTGTGCGGGACCTGCCACGTAACG
>17.2|3912371|35|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
TCGTCACGGTGTGGCGCTGGCAGATCAGCTGGTGC
>17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
ATGCCGTCCCGCCGGCGGCCCGGCCGCTCGGGAG
>17.4|3912500|35|NZ_CP022961|PILER-CR,CRT
CCGGCCTGGGCGCGGCGTTGAAGCATGCGCACCGA
>17.5|3912565|32|NZ_CP022961|PILER-CR
ACCAGGCTGGGCGCCCAGCCTGGGGCGACGGG
>17.6|3912627|36|NZ_CP022961|PILER-CR
TTGATCAGTTCCGCCGCCCACAGGTATGTGTCGATT
>17.7|3912693|36|NZ_CP022961|PILER-CR
AGCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGA
>17.8|3912759|35|NZ_CP022961|PILER-CR
TCTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTG
>17.9|3912824|35|NZ_CP022961|PILER-CR
TGCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCG
>17.10|3912889|38|NZ_CP022961|PILER-CR
ATGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGAT
>17.11|3912957|40|NZ_CP022961|PILER-CR
GGGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCA
>17.12|3913027|33|NZ_CP022961|PILER-CR
AGAATCCTGCGTAGCTGGCCGGCCACCTCAGGC
>17.13|3913090|36|NZ_CP022961|PILER-CR
CCTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGA
>17.14|3913156|37|NZ_CP022961|PILER-CR
GCCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCA
>17.15|3913223|40|NZ_CP022961|PILER-CR
GGGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGC
>17.16|3912565|31|NZ_CP022961|CRT
CCAGGCTGGGCGCCCAGCCTGGGGCGACGGG
>17.17|3912626|36|NZ_CP022961|CRT,CRISPRCasFinder
TTGATCAGTTCCGCCGCCCACAGGTATGTGTCGATT
>17.18|3912692|36|NZ_CP022961|CRT,CRISPRCasFinder
AGCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGA
>17.19|3912758|35|NZ_CP022961|CRT,CRISPRCasFinder
TCTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTG
>17.20|3912823|35|NZ_CP022961|CRT,CRISPRCasFinder
TGCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCG
>17.21|3912888|38|NZ_CP022961|CRT,CRISPRCasFinder
ATGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGAT
>17.22|3912956|40|NZ_CP022961|CRT,CRISPRCasFinder
GGGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCA
>17.23|3913026|33|NZ_CP022961|CRT,CRISPRCasFinder
AGAATCCTGCGTAGCTGGCCGGCCACCTCAGGC
>17.24|3913089|36|NZ_CP022961|CRT,CRISPRCasFinder
CCTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGA
>17.25|3913155|37|NZ_CP022961|CRT,CRISPRCasFinder
GCCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCA
>17.26|3913222|40|NZ_CP022961|CRT,CRISPRCasFinder
GGGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_17

CRISPR arrays

The CRISPR arrays of NZ_CP022961_17

>merge|NZ_CP022961|17|3912276-3913291|PILER-CR,CRISPRCasFinder,CRT,CRISPRCasFinder
GTCACCCATCACCCCTGGAGGGATCGCAACGTGGGGCGCTGCTGTGCGGGACCTGCCACGTAACGGTCGCCCATCACCCCTGGAGGGATCGCAACTCGTCACGGTGTGGCGCTGGCAGATCAGCTGGTGCGTCGCCCATCACCCCTGGAGGGATCGCAACATGCCGTCCCGCCGGCGGCCCGGCCGCTCGGGAGGTCGCCCATCACCCCTGGAGGGATCGCAACCCGGCCTGGGCGCGGCGTTGAAGCATGCGCACCGAGTCGCCCATCACCCTGGAGGGATCGCAACACCAGGCTGGGCGCCCAGCCTGGGGCGACGGGGTCGCCCATCACCCCTGGAGGGATCGCAACTTGATCAGTTCCGCCGCCCACAGGTATGTGTCGATTGTCGCCCATCACCCCTGGAGGGATCGCAACAGCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGAGTCGCCCATCACCCCTGGAGGGATCGCAACTCTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTGGTCGCCCATCACCCCTGGAGGGATCGCAACTGCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCGGTCGCCCATCACCCCTGGAGGGATCGCAACATGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGATGTCGCCCATCACCCCTGGAGGGATCGCAACGGGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCAGTCGCCCATCACCCCTGGAGGGATCGCAACAGAATCCTGCGTAGCTGGCCGGCCACCTCAGGCGTCGCCCATCACCCCTGGAGGGATCGCAACCCTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGAGTCGCCCATCACCCCTGGAGGGATCGCAACGCCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCAGTCGCCCATCACCCCTGGAGGGATCGCAACGGGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGCGTCGCCCATCACCCCTGGAGGGATCGCAAC

>NZ_CP022961|17|3|3912276-3913291|PILER-CR
GTCACCCATCACCCCTGGAGGGATCGCAAC	GTGGGGCGCTGCTGTGCGGGACCTGCCACGTAACG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCGTCACGGTGTGGCGCTGGCAGATCAGCTGGTGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGCCGTCCCGCCGGCGGCCCGGCCGCTCGGGAG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCGGCCTGGGCGCGGCGTTGAAGCATGCGCACCGA
GTCGCCCATCACCCTGGAGGGATCGCAACA	CCAGGCTGGGCGCCCAGCCTGGGGCGACGGGG
TCGCCCATCACCCCTGGAGGGATCGCAACT	TGATCAGTTCCGCCGCCCACAGGTATGTGTCGATTG
TCGCCCATCACCCCTGGAGGGATCGCAACA	GCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGAG
TCGCCCATCACCCCTGGAGGGATCGCAACT	CTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTGG
TCGCCCATCACCCCTGGAGGGATCGCAACT	GCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCGG
TCGCCCATCACCCCTGGAGGGATCGCAACA	TGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGATG
TCGCCCATCACCCCTGGAGGGATCGCAACG	GGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCAG
TCGCCCATCACCCCTGGAGGGATCGCAACA	GAATCCTGCGTAGCTGGCCGGCCACCTCAGGCG
TCGCCCATCACCCCTGGAGGGATCGCAACC	CTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGAG
TCGCCCATCACCCCTGGAGGGATCGCAACG	CCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCAG
TCGCCCATCACCCCTGGAGGGATCGCAACG	GGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGCG
TCGCCCATCACCCCTGGAGGGATCGCAAC

>NZ_CP022961|17|17|3912276-3912500|CRISPRCasFinder
GTCACCCATCACCCCTGGAGGGATCGCAAC	GTGGGGCGCTGCTGTGCGGGACCTGCCACGTAACG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCGTCACGGTGTGGCGCTGGCAGATCAGCTGGTGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGCCGTCCCGCCGGCGGCCCGGCCGCTCGGGAG
GTCGCCCATCACCCCTGGAGGGATCGCAACCCGGCCTGGGCGCGGCGTTGAAGCATGCGCACCGAGTCGCCCATCACCCTGGAGGGATCGCAACACCAGGCTGGGCGCCCAGCCTGGGGCGACGGGGTCGCCCATCACCCCTGGAGGGATCGCAAC	TTGATCAGTTCCGCCGCCCACAGGTATGTGTCGATT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	AGCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TGCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGAT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GGGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	AGAATCCTGCGTAGCTGGCCGGCCACCTCAGGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GCCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GGGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGC


>NZ_CP022961|17|3|3912276-3913291|CRT
GTCACCCATCACCCCTGGAGGGATCGCAAC	GTGGGGCGCTGCTGTGCGGGACCTGCCACGTAACG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCGTCACGGTGTGGCGCTGGCAGATCAGCTGGTGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGCCGTCCCGCCGGCGGCCCGGCCGCTCGGGAG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCGGCCTGGGCGCGGCGTTGAAGCATGCGCACCGA
GTCGCCCATCACCCTGGAGGGATCGCAACA	CCAGGCTGGGCGCCCAGCCTGGGGCGACGGG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TTGATCAGTTCCGCCGCCCACAGGTATGTGTCGATT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	AGCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TGCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGAT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GGGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	AGAATCCTGCGTAGCTGGCCGGCCACCTCAGGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GCCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GGGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC

>NZ_CP022961|17|18|3912596-3913291|CRISPRCasFinder
	GTGGGGCGCTGCTGTGCGGGACCTGCCACGTAACG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCGTCACGGTGTGGCGCTGGCAGATCAGCTGGTGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGCCGTCCCGCCGGCGGCCCGGCCGCTCGGGAG
GTCGCCCATCACCCCTGGAGGGATCGCAACCCGGCCTGGGCGCGGCGTTGAAGCATGCGCACCGAGTCGCCCATCACCCTGGAGGGATCGCAACACCAGGCTGGGCGCCCAGCCTGGGGCGACGGGGTCGCCCATCACCCCTGGAGGGATCGCAAC	TTGATCAGTTCCGCCGCCCACAGGTATGTGTCGATT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	AGCCGCGCCCAGACTCCCGAGTAGATGACCTCGGGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TCTCGCTCATGGCTGCGCTCCGTCAGATGGTGGTG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	TGCGTCTTCTCAATCTGGATTGCCGCCCGCAGGCG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGACCTCCGCCGCTCGGGCCTCCGGCCCGCCGGCGAT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GGGTCCGGGTGTCGGGCACCCCACCGGACAGGACCCGCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	AGAATCCTGCGTAGCTGGCCGGCCACCTCAGGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCTCAGCCCAGCCGCGCTTGGTGAGCTTGGCGCCGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GCCGGGTGCGGTGGATCTGCCTGGACACCCGGTCCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GGGTACCTCCCGATCGGGGCTCCGGTCTGCGTTGGCGCGC
GTCGCCCATCACCCCTGGAGGGATCGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565647.1|3894151_3895519_+|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|240543
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl|CDD|187818
NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein	csm3gr7	COG1337_csm3gr7_CAS-III-D	gnl|CDD|187857
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	cas5	cd09693_cas5_CAS-I	gnl|CDD|187824
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NZ_CP022961.1|WP_095565663.1|3923940_3924252_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565656.1|3913457_3914861_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	gnl|CDD|274900
NZ_CP022961.1|WP_157756808.1|3897242_3899486_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565652.1|3904002_3906399_+|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl|CDD|187857
NZ_CP022961.1|WP_095565660.1|3921600_3921831_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565661.1|3922068_3922695_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NZ_CP022961.1|WP_095565649.1|3896961_3897258_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565648.1|3895515_3896934_+|hypothetical-protein	unknown	unknown	gnl|CDD|380462
NZ_CP022961.1|WP_095565651.1|3899554_3899929_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NZ_CP022961.1|WP_095565646.1|3890496_3894126_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|238429

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein	csm3gr7	COG1337_csm3gr7_CAS-III-D	1.8e-23	78.0	0.0
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	5.1e-61	201.2	0.0
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	cas5	cd09693_cas5_CAS-I	1e-19	65.8	1.6
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	3.2e-21	70.1	0.0
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	6e-57	188.1	0.0
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	2.7e-96	317.2	0.0
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	7.6e-42	137.9	0.0
NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	1.7e-13	45.2	0.0
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	5e-14	47.8	0.0
NZ_CP022961.1|WP_095565652.1|3904002_3906399_+|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	8.1e-17	56.0	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565647.1|3894151_3895519_+|MATE-family-efflux-transporter	gnl|CDD|240543	cd13138, MATE_yoeA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	1.74905e-87
NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein	gnl|CDD|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	5.87657e-18
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	gnl|CDD|187824	cd09693, Cas5_I, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.81302e-17
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.57729e-134
NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein	gnl|CDD|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	7.01402e-09
NZ_CP022961.1|WP_095565652.1|3904002_3906399_+|hypothetical-protein	gnl|CDD|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	4.93391e-15
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.97781e-24
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl|CDD|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	2.70279e-63
NZ_CP022961.1|WP_095565648.1|3895515_3896934_+|hypothetical-protein	gnl|CDD|380462	cd19539, SgcC5_NRPS-like, SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs. SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.	1.70186e-15
NZ_CP022961.1|WP_095565646.1|3890496_3894126_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	3.18524e-171
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.06943e-52
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.62384e-18
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	2.80672e-62

Protein sequences

>NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6
MRFYVDVAGPDAALPWKHVHGVAHAVVYGLLGDQAPDLATDLHDHGWNGTGLRPIGITPPAFTGARRKPGAFMMSTNGRIWFGSPVPELAALLLTGVTSRRELRWGPVTLTVKGAQLEPVGGAETPAVLETRTPILIKAEGDRYLLPEDDGYTERLLANIRRKAKALGVPGDADLEVLDAGKRRRYDVCGGIRIGATAKIRLHADPRLVDALREWGLGLATIEGFGWVR
>NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein
MTTGRDGAVLHAVRAAHPLRAAESLAWFTPGTPPGKEIVGYTLSARAAVWLRVGPDGTVQAVDGDPLAEAYEMLLFDGDRELRWLRTPDGLGRAVAVGEDPASLPPGDDVTVDQRPGRDLAAATPRRGDTQRRLLAGEAREHERTGWTALAGRRMATVALPMPFPGTGRWIAVETVEYLVEDGHGNLDVADSRTCRLLPLDEAQTLVRTAPASTHAERTTA
>NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein
MGQSTGERIEILGTLVCVGPVHVGGWDTTAEASLTVARDGTGRVCLPGTSIAGSLRAYLGGIHRFGGTAPNDPANALFGTVVPDSRDGSPSWLRVDDAHLIGNDVVPVVRDGVGIDRRSGSAAANFLYTRQLLPAGTRFALRIVADTPTGADAPNYPGGWPRLIDDAVATLVAGLRQGRVPIGAGRGRGLGRVELRDVTVRRADLSDPAGLVGWLAGRTPATGPAPEADPPPDGRLRITVRWKPLGPLLVRDSVAGTVVDTLPLTEMAVDDTVRLLLPGSSIRGTVRAHTERIVRTLRREDAPETFDEALRRPPPGVDVLFGSAPTGRRTDPDGAGTDGAGVDTGGSDSGWRGVLAFADCHSVERVPAEQWNRILAVVPDRVPDGSKAEPREQRQERNTERDRARSALRTTLDKIRLAIPLDVSDHVAIDRWTGGAADHRLFSVLDPAGTVAWDPIQIEVDTARLAASTDSAGATSAPLALPLLLLALRDLRDGWLSLGHGGTRGRGQIQVTEVTFAGDGLVEPWRSLAGNTLDAILADPPPQVEAAMTTWQSTFEEAA
>NZ_CP022961.1|WP_095565652.1|3904002_3906399_+|hypothetical-protein
MTLPTDFDVTIEFLSDWHVGTGQGRLGSVDAVVRRDAAGLPFVPAKTLLGVWRDACETVAATFDRAADRPDAWTAWVAWLFGDQDAAAGRLPAPAALRLTPGYAPAWLRNSVRGRPELAQAAVVLRPGVSIDGVTGTVADRLLRVEERAIRGLNLRSRVSVVLPEPTGAGAQLPEPAELMLRAGARLIEALGGKRNRGGGRVAVLLPDAVIENPDVHPTLTDDRLADLLAAGVPATPPPPPATPPVATFHPYDRTRPDRRRTVRVVLRVVTPVVAAKQVLGNLVIGRDAIPGTALLGTMLAHAQPGHGDRRGRIGLADIGVGDAVPAVGDPDDPVSVRPAAPVPAAWQRGDKGQGASVHNSLVRAAQPGARAKGMNGWIVPDGDRWRVLDPATAASTHAVVDDDARRPTVASGGVYSYLGIAADSLLCSDVVLPADVELRLRSGDRLRFGRSRKDDYGLVEVVDVVELAAPPRPVAPVDGRLRVWCVSDVLLRDDRLNPDPSPHGLARALTTALAPASCAVPECQPASATGVGAGTDAAAEPGTAVEAVTAAERRDGFGVAWGRPRPSQVALRAGSVVTLEVTGTPDPDRLAGLERDGLGERTAEGYGRIRFNPPELTVERPSVAFSDAAPARDAPADPDPQDIPDDPDPLEINAWRRVIRRASAELEPDALIPGIGKMAKRRAQLGALRAQLERLTLPGGSALVRHWIDGTRAVRARRDAWGEDTLRNLAALLLDDANLIWQRLDLHGPMNHLVLAPGREDRIREGLRTEAVVTTVTDALRKLLRGDARSRSTREEH
>NZ_CP022961.1|WP_095565651.1|3899554_3899929_+|hypothetical-protein
MADGGDAPEVRNLTPHVVRLIGDGQIVALEPAGPPARVVLHADRPDGTVRIGPLVVPLKRTAASPLVTGLPERRPGVLLIVARPVAEARPDRDDLVYPHDTVRDAAGVIVGCRSLGRPALADDT
>NZ_CP022961.1|WP_157756808.1|3897242_3899486_-|hypothetical-protein
MRLVVHIAGEADLLLDSQPQSPRVTEEVRAERVAQRRAVLADVLSDGGGAEVARRMLTKNEWHDDAPGTCPPSPLFGVLDELTGHDATRDVSVLVLGTRQDPAHPLDTEPIARVLVDVLGHLAAGNATCPVERATVVLLAKGLDEKGVVAAVTDHLEPAPRYRQALLTWGSGATGIAMGVLTALSRAGLRWQLVPTSKPGRYPIIDPLDDLDADPVAGVLVRWRLFAALEAAATADPPTVRLGDAARDLVGRAAQRHRDGLAVRDCASLRAVVADAVVRRDGTASMAVRRYVTSRYEELLDIDRADHPGAEDLLRRAERTLCDEEGRAYVTLGPMLGWVARMRDEDPAVRASIGLPSHTWLCSPEVQALRKIGNGSHCLKPPAPGESGTIGAYLRRYDVDGTGWREAGLPEPAVTPADTVLAVWPAGTGDRPEGRRDRTGPPGEPAAGTDRRHSETVGEQLMAGLPGVVTAHLDEAPNIRIRAVVFGTEGSYPNAELDVQAVRSGLARTEGRPRGGRRRSGGRIRGEAWAEPVQGKVPDLAAVERAIEARITPGTGALLLVPTGGKPIVLALLRAMRRIGARHGIPLFVREMAIPKTAGAYSDVHLWPALTGGDLPLLHAARASLHNLELDVAWRLLAASAIGSGVADETRRLADAFASRQPLTDGDQGTGWGRGMIAERLELVDDALGHVTSPEARIRLLVLAADAMEASVKAGWRGDTGSSASCWKPRRGPMISTSPGRRGCCCC
>NZ_CP022961.1|WP_095565649.1|3896961_3897258_-|hypothetical-protein
MLLLLNAARDRAPITHGTIPDADAVVAAAADTLAPDERGLTAAEAAALPRDVATLLRAAVTAATDLRPGGPGRGNKLLALHRRIGAKIDAAITLRPTR
>NZ_CP022961.1|WP_095565648.1|3895515_3896934_+|hypothetical-protein
MITAYTTDVEFHGGRARTAPLTWGQEMIWDLIGNLDDARNYAVLTRWMPIPLLLSVGDALESLGELARRNEALRTMYHRTASGDARQEILSAGTMPVEIVDRPADDPTDYSSIVTDCLVRASEAGFDHEKELPIRFSVILQDGIPILLAFAVSHLSADFIGADLLVTELGAMLQARADGRPWPPPRHCRQPADMAAVEGRPAGQLRNIEAARFIRQQLDRAHPDMLPARATPATPRFHRGQLESSALAVAIGPAARRHRTSTSVLLLAITSALMRCVCPGRAYPIDLLLGNRADPALAGTVCSLSQSILTVIDLTPDSFAGLVAHCAAITAEARRYGWHRKRVVQGILDAAGAGRGCQFNDIWSQLPGRPSRLPATPAELGAMAESTTFSWPEQVPEKNKDLFMGVRGTGDRMHLSLFADTALLPPGDIRAFLDTFERAAISLAFADVTLDQIAHWFAEAGARYAHLNGGQR
>NZ_CP022961.1|WP_095565647.1|3894151_3895519_+|MATE-family-efflux-transporter
MTDMTRGPAVRQIVGFALPLTAASLFMQAYLLVDGIVVGRYVGVEGLAAVGASGPLFYLLNAMFIGLGTAFTIRLAHLRGGQRDEQRRDVVVALATVTVGWTLGSIVLVTVLAKPVLALMGITGTLAGQCAHFIGILSIGFPGMFGSAAVSAYLRGLGNSRAAMWVQATGNVINIGLAWLFVGGLGLGVGGGALATAVSATVAAVVGVLASGRLYPLPAGRPATPAVRGELADAIRLGLPLATQHIILALGIMVLVWIIERYGETVMAGFTIVSRIEAFTAILFLSFSGAMTTFAAQNLGAGDIERARRALVQTLGLTVGLTVVFSAVVLAAHRPIVAVFTDDPAAREVAGRYLLIIYPFFALYTVMVVLHGYLNGARRTTVPLICTILAFGLVQLPFAYLLSRPFGIQAVMWAVVASWTTGLTYSIFCLRHVLLPRRTPAGGPIPTPVEVRGSS
>NZ_CP022961.1|WP_095565646.1|3890496_3894126_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSIAIVGASVRLPGVEGLDDLWRVVSTGASLTRPFPQHRRETLSEYIHYLRATTVEPVDDDGLDFHNGCYLDSVDTFDYAAFGMTPRQAALTDPHHRMVLRAMFLALEDAGYSADRLRGSRTGVFVGFATNPGSTYMDYISRVEPSLSQQAITGNIPAMLANRLSHLLDLRGPSLVVDTACSATLVAVHQAKNALMAGDCDMAVVGGARIVFAPVKHPHSAIGIESSDGVTRTFDEAADGTGFGEGSGAVVLKRTDRALADGDEIYAVIRGSAVNHDGHTDGITSPSARSQADLLLAAWENAGIDPRTLGYFEAHGTATRVGDPIEHEGMKLAFAEHTTDRSFCAVGTVKANVGHLFEGSGVIGLLKAVAVLRHRQLPPQANFVSPNPQLDFTSGPLFVPTSLRPWETDGGPRRCGVSAFGLGGTNAHVVVEEHIAPAPATDPAGDHPSGEHLFTLSGATIRSLSGLLRGYLRFIDEGGLAGIDIADVCHTTQLSRSAHRYRIALAVTGIDDLRAGIERILADDGPQVTGALAETAQAYLRGEPVDWRRLAAGRKHRIVRLPHYVFDETTAWLDFPQDWRQTMSLERTTAQHPVTHDVRLRPVPAPEPTPTGTGTGTGTGTMLALIDPSTDAEAVLAPALTDGSRIIRLGEPLGPDGPTFSADSPAAYEHLVRLADEHQVTHLVYALAFESAPAADIEEIESRSAKNLHGLFHLSKALMAAGAKLDLIVLTRTAISADEGDAATVTDNAALVGFGKVLVREYPYVQVKHVDVDMSVPAAAVRAEILGDAYGLSVLRGEQRMREVFVEVPDIELTTGDPGPRPYLRSGGTYLITGGTGALGLAVARDFATAQPDITVVLLSRSGLPPRERWDELPASASESAVTTRIQTVRDIEALGARVLAMAVDAGDSKALAEAVAQLRADHGRIDGIVHAAGLPGGSTVMFRQLDEFDAVVRAKLHSAFVLKESTRTDPPDFIAHFSSVASVFPAPGQADYAAANYYLDNLARSQSGGRCHMLAVDWVAWKEIGMAVDYGTNGDTMFKALPTAVGLAVLDAGLRSGRSRLFAGELNYGGELIHLLRSYDVALSDDIEATVQQQMHALEERLAKATDKIRTTIEAVTVHLDGRPDEQYSDVELSVARCLALAFGYDRLDVEADFFDLGGDSLMATTVANHIAVYHGVSYDVADLLADRTTAEIAYHIEDLRDFAASSL
>NZ_CP022961.1|WP_095565656.1|3913457_3914861_+|hypothetical-protein
MGLSTTVAPPALALTAHPLQRCGAWAVAVLAGRDEPGELTPDDLDTVAGRLVDDVVTASTKPKKPEPDWWKVLFALYPNAKPTHAKRSRDPDTLRPAVVALFAADQPGPTALPCAFCSAPATVLWAKSHLPMFDTPHAVNNLPPGTAGWPVCRGCRIALWALPYGAWLTAGSATVLMCANPAVERRFVDRNVTRARRIQQVGFTGVPVDAGAEAVALAALRAHAADAPADAVLWSFKNDNKSPWLKVSATRQAIARLLVRIESDRATRRGWRRLRRALAGRNRDRRGHAAIARTLFAGEPGPVDRLLRALQHEFTDPPNDPATTDGWRRLARAYQEEMYGMDVERLAPARRLVAAWIMAERNPRGRFNEYAKVAGKGYDLHRLLMEAGARLLRDGGQPPDISGVAPALLSGGPDSWRWRAQLFFEVVADLVEARAAIGRKPDEPDGDEDEDDATIRFDPNEMEEEYA
>NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MAYLAGKLVLAVTAGAPNNGRGEATTGRVKQTRIRQHIYPYVSAQAARRWLRDTMTEQGAVPSPTERVGRKQSKAQKATTEADPLRYVDDDLFGFMKATAKSEDADTTLRDSPFMIGTLLSVEPARPTEDFGVMARGIDDPVLHAHEFYTADLAAPFLIDLPRIGTFTTPNERGAGKANYLTREAALAVAEAVNAGAETVLFRGQPAVRLPLQTRRERAALLLEALSELSGGAKKGLHYGDRTPTLLMLLAMEGGVNPLEFAVGGADDGSGLQVRGDVLRAELEAWDGRWQPPVRVGWRPGFRDVERKQFEADVAGEIDAGTVTVQHPRTMLRTLAAELRAGVHDAWFDDPAR
>NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5
MPSGTTTTGPPGGGGPVEATRIELFAPVASFRDPMFPGLTRCLPVPPSSALRGMLAAATGAAAEPVPLGYSARAAGTGVDAETYHPIAADGANPAVAGRVRAVKGGTTVKDRPFLAHLSVTLWIPEPDGTRIAAALRRPVWGLRLGRSQDLVYVRSVSPVLLRPADVAVVGHALAPPGGHDAGAAVTVRLAEWIAADRLTTRYGDYLWCAEPAGRLPVRHALRDGDRAVWLRPAPAGPGQR
>NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3
MAAGPAQNPAQDRILDEVWAKSVDRSGRTGRVGRAERLTEHSRATWVAAGTIADRIGSAGVLAGWSSFWPLVTLAALLHDAGKVAEGFQRQVKLRGHRWGERHEVLSLAYVELLAGGLPPADLALLLAGVGLHHRCLRSESGSGALRDLYPESAAWERIFGYHPDPPPGQPNGQVPAPRHRALLAWYAGQLGLAVPQDGQRRLWQRARDQFARLRVAWDAPVDPERGLVAVLFQGAVTLADHSASAHVPLQTHLPLRPDYLAGFGRRPYPHQERAAATDGHLVLVAPTGSGKTEAGLGWAARQLPAMPGRPRVVWVLPYRASIDAAATRFAQDLRPAPGQAGAPGGASAEAEAEAGADIGVLHGSAALSVLADATEDDCVPTAADARGAGARAGAMRLFAQRFRVATVYQLLIGAVAGPRYASVLLEQANSLIVLDELHAYDPQTFGRICAAMRLWEELGSRVAVVSATLAPPMVELIRETLRHPVSVHRAAAGTAPDRHRLVLDERPLTDPSSLAVIREWLADGYSVLLVANTVATAQELYRVLAPEVDPADPDATLLLHSRFRARDRAAIERRLLARHGERRPGQSARRGGLVVATQAVEVSLRLDFDRGATELAPIEAVAQRAGRVNRLGHHPEGAVPYRVHRGERPHPYPPDALDAAWSALNDAPGPVMSEQTVDHWLTLAYRTDWGRRWAEQARHSRDAFGETFLTFTEPFTDRTEFLDGLRESFDTVEVLLEADRQEYARLTAGPDGHALLGAGLLIPISYRQWHTLDRTGTIGRGIPVVDAPYSPEHGLDPDGTHRTTTPLPSAEDTVL
>NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein
MGGVHIKYLLHCPRQLWLYSHGYRPEARNEAVAFGEVVDDTTYRRHHDIDLGAAKIDWVTRGAVVHETKSSRQPSPQHEAQVRHYCLLLARRGVNVRGGVVHYPLIRRTTRVAWDDTARRAAETAEAQARQVSAAATPPPRLPRASCRGCSYRDYCWGDS
>NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MSASGQSYWLTEPCRIRREDNSIRIERADRTPVRIPITDIRDLVVFDNADINTAAVSLLSRHRITVHLLDHYGNYAGALTPAEDMSSAHVVRAQVTLTADPVARLAVARALVGATAANVAWALDTDLLAGPLERLPAQVRACADAEELMGIEGNFRRTAWGVLDTLLPPWLRLGGRSRRPPSNAGNAFISYLNAITYARVLTAIRCTPLHPAIGFLHADSDRRRNTLALDLAEPFKPLLAERLLRRAAAQRTLTAADFVSDVRSASLSTAGRKKVSIMVREELATTVHHRQLKRKVSYEELIHLEALKLVRLCLEGTPYKPFRPWW
>NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2
MFVVLVYDTAVERNPNALRTCRQYLHWVQRSVFEGELSTAQHRSLMTALRQQLDLGHDSVRVYRIGSPHLVQVDALGTELGNSDSVL
>NZ_CP022961.1|WP_095565660.1|3921600_3921831_+|hypothetical-protein
MDYDQQRRDLVAQGRSNCGRIAISVRGMQSWLVRIAPGTVRQLDEEQFAARLREAAGELIRDQFAGIRVLKSRIYG
>NZ_CP022961.1|WP_095565661.1|3922068_3922695_+|hypothetical-protein
MSLGAIVRNTASQIAYRTTVTLRVSDPQGRTAIDPLNAAQLILEIPIIMPGQQVAVASSAGLRTDLSPAGRPDKVASFDVTLGPTLWLPPENTTLFPTVTTTYLGVDRFDGDPTSGRVRYSVTSTSCRPLVARGSFAVFLDQTGAVVGGAFDPDTTSPHCDAMDHEESLSTIHSIPTGIDEAKTVVSVYCDIATVGGGRVKPSGAPFN
>NZ_CP022961.1|WP_095565663.1|3923940_3924252_+|hypothetical-protein
MKRPPLPIAVASGLILVEAIVFIVFGTPILAALGVLTSAIFIFYTLRGNRQIARLTIISLAIKLLMLIPYWNPLRLFPVVLWTAVTLLFWLPEQSREWFRQND

Crispr_ID: NZ_CP022961_18

• CRISPR_ID: NZ_CP022961_18
• CRISPR_location: 3921054-3921557
• CRISPR_type: Unclear
• Repeat_type: NA:?
• Spacer_info: 7 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7,cas6,csx19,csm3gr7

Consensus repeat of NZ_CP022961_18

Consensus_repeat	Method
GTTGCGATCCC------TCCAGGGGTGATGCGGCGAC	PILER-CR
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CRT
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CRISPRCasFinder

spacers of NZ_CP022961_18

>18.1|3921085|36|NZ_CP022961|PILER-CR,CRT
ATCAGCAACACCCGCCGCCACCCATCCGGGTCGCAG
>18.2|3921152|36|NZ_CP022961|PILER-CR,CRT
CGGTAGGGGTGGCGTTGCTCTGGCGTCCATCCGGGC
>18.3|3921219|34|NZ_CP022961|PILER-CR,CRT
GGTCGGCCGGATGGTTGGGGGTTGATGGCTTGGG
>18.4|3921284|41|NZ_CP022961|PILER-CR,CRT
TGGCCGCCGTAGACCACCCTTCTGACCCCGACCTGGTCCCA
>18.5|3921356|36|NZ_CP022961|PILER-CR,CRT
CTGCGGAGCGCGGCCGGTCTGGCCGCGCTCCGGCTG
>18.6|3921423|36|NZ_CP022961|PILER-CR,CRT
CGTACTTCCTTCAGTGGATGATTTGCGATCATCCAC
>18.7|3921490|36|NZ_CP022961|CRT
CGGTTTGCTGCGGGTCCGACACCGCGGCGAGCTGGG
>18.8|3921085|37|NZ_CP022961|CRISPRCasFinder
ATCAGCAACACCCGCCGCCACCCATCCGGGTCGCAGG
>18.9|3921152|37|NZ_CP022961|CRISPRCasFinder
CGGTAGGGGTGGCGTTGCTCTGGCGTCCATCCGGGCG
>18.10|3921219|35|NZ_CP022961|CRISPRCasFinder
GGTCGGCCGGATGGTTGGGGGTTGATGGCTTGGGG
>18.11|3921284|42|NZ_CP022961|CRISPRCasFinder
TGGCCGCCGTAGACCACCCTTCTGACCCCGACCTGGTCCCAG
>18.12|3921356|37|NZ_CP022961|CRISPRCasFinder
CTGCGGAGCGCGGCCGGTCTGGCCGCGCTCCGGCTGG
>18.13|3921423|37|NZ_CP022961|CRISPRCasFinder
CGTACTTCCTTCAGTGGATGATTTGCGATCATCCACG
>18.14|3921490|37|NZ_CP022961|CRISPRCasFinder
CGGTTTGCTGCGGGTCCGACACCGCGGCGAGCTGGGG

CRISPR arrays and Neighbor proteins around NZ_CP022961_18

CRISPR arrays

The CRISPR arrays of NZ_CP022961_18

>merge|NZ_CP022961|18|3921054-3921557|PILER-CR,CRT,CRISPRCasFinder
GTCGCCGCATCACCCCTGGAGGGATCGCAACATCAGCAACACCCGCCGCCACCCATCCGGGTCGCAGGTCGCCGCATCACCCCTGGAGGGATCGCAACCGGTAGGGGTGGCGTTGCTCTGGCGTCCATCCGGGCGTCGCCGCATCACCCCTGGAGGGATCGCAACGGTCGGCCGGATGGTTGGGGGTTGATGGCTTGGGGTCGCCGCATCACCCCTGGAGGGATCGCAACTGGCCGCCGTAGACCACCCTTCTGACCCCGACCTGGTCCCAGTCGCCGCATCACCCCTGGAGGGATCGCAACCTGCGGAGCGCGGCCGGTCTGGCCGCGCTCCGGCTGGTCGCCGCATCACCCCTGGAGGGATCGCAACCGTACTTCCTTCAGTGGATGATTTGCGATCATCCACGTCGCCGCATCACCCCTGGAGGGATCGCAACCGGTTTGCTGCGGGTCCGACACCGCGGCGAGCTGGGGTCGCCGCATCACCCCTGGAGGGATCGCGAGG

>NZ_CP022961|18|4|3921054-3921489|PILER-CR
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	ATCAGCAACACCCGCCGCCACCCATCCGGGTCGCAG
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CGGTAGGGGTGGCGTTGCTCTGGCGTCCATCCGGGC
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	GGTCGGCCGGATGGTTGGGGGTTGATGGCTTGGG
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	TGGCCGCCGTAGACCACCCTTCTGACCCCGACCTGGTCCCA
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CTGCGGAGCGCGGCCGGTCTGGCCGCGCTCCGGCTG
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CGTACTTCCTTCAGTGGATGATTTGCGATCATCCAC
GTCGCCGCATCACCCCTGGAGGGATCGCAAC

>NZ_CP022961|18|4|3921054-3921556|CRT
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	ATCAGCAACACCCGCCGCCACCCATCCGGGTCGCAG
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CGGTAGGGGTGGCGTTGCTCTGGCGTCCATCCGGGC
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	GGTCGGCCGGATGGTTGGGGGTTGATGGCTTGGG
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	TGGCCGCCGTAGACCACCCTTCTGACCCCGACCTGGTCCCA
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CTGCGGAGCGCGGCCGGTCTGGCCGCGCTCCGGCTG
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CGTACTTCCTTCAGTGGATGATTTGCGATCATCCAC
GTCGCCGCATCACCCCTGGAGGGATCGCAAC	CGGTTTGCTGCGGGTCCGACACCGCGGCGAGCTGGG
GTCGCCGCATCACCCCTGGAGGGATCGCGAG

>NZ_CP022961|18|19|3921055-3921557|CRISPRCasFinder
TCGCCGCATCACCCCTGGAGGGATCGCAAC	ATCAGCAACACCCGCCGCCACCCATCCGGGTCGCAGG
TCGCCGCATCACCCCTGGAGGGATCGCAAC	CGGTAGGGGTGGCGTTGCTCTGGCGTCCATCCGGGCG
TCGCCGCATCACCCCTGGAGGGATCGCAAC	GGTCGGCCGGATGGTTGGGGGTTGATGGCTTGGGG
TCGCCGCATCACCCCTGGAGGGATCGCAAC	TGGCCGCCGTAGACCACCCTTCTGACCCCGACCTGGTCCCAG
TCGCCGCATCACCCCTGGAGGGATCGCAAC	CTGCGGAGCGCGGCCGGTCTGGCCGCGCTCCGGCTGG
TCGCCGCATCACCCCTGGAGGGATCGCAAC	CGTACTTCCTTCAGTGGATGATTTGCGATCATCCACG
TCGCCGCATCACCCCTGGAGGGATCGCAAC	CGGTTTGCTGCGGGTCCGACACCGCGGCGAGCTGGGG
TCGCCGCATCACCCCTGGAGGGATCGCGAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	cas5	cd09693_cas5_CAS-I	gnl|CDD|187824
NZ_CP022961.1|WP_095565667.1|3927437_3928502_-|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl|CDD|335469
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NZ_CP022961.1|WP_095565663.1|3923940_3924252_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565656.1|3913457_3914861_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	gnl|CDD|274900
NZ_CP022961.1|WP_095565664.1|3924541_3925189_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NZ_CP022961.1|WP_157756810.1|3931663_3933115_-|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl|CDD|293758
NZ_CP022961.1|WP_095565665.1|3925367_3926366_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|381302
NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein	csm3gr7	COG1337_csm3gr7_CAS-III-D	gnl|CDD|187857
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl|CDD|187818
NZ_CP022961.1|WP_095565666.1|3926494_3927364_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|375319
NZ_CP022961.1|WP_095565669.1|3929991_3931638_-|hypothetical-protein	unknown	unknown	gnl|CDD|227721
NZ_CP022961.1|WP_095565660.1|3921600_3921831_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565661.1|3922068_3922695_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565668.1|3928498_3929995_-|arylsulfatase	unknown	unknown	gnl|CDD|293762
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	1.7e-13	45.2	0.0
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	3.2e-21	70.1	0.0
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	5.1e-61	201.2	0.0
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	cas5	cd09693_cas5_CAS-I	1e-19	65.8	1.6
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	2.7e-96	317.2	0.0
NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein	csm3gr7	COG1337_csm3gr7_CAS-III-D	1.8e-23	78.0	0.0
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	6e-57	188.1	0.0
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	5e-14	47.8	0.0
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	7.6e-42	137.9	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.97781e-24
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	gnl|CDD|187824	cd09693, Cas5_I, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.81302e-17
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.57729e-134
NZ_CP022961.1|WP_095565668.1|3928498_3929995_-|arylsulfatase	gnl|CDD|293762	cd16143, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	2.28269e-169
NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein	gnl|CDD|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	7.01402e-09
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.06943e-52
NZ_CP022961.1|WP_157756810.1|3931663_3933115_-|sulfatase-like-hydrolase/transferase	gnl|CDD|293758	cd16034, sulfatase_like, uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	2.34378e-159
NZ_CP022961.1|WP_095565667.1|3927437_3928502_-|formylglycine-generating-enzyme-family-protein	gnl|CDD|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.00591e-79
NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein	gnl|CDD|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	5.87657e-18
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl|CDD|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	2.70279e-63
NZ_CP022961.1|WP_095565666.1|3926494_3927364_+|helix-turn-helix-domain-containing-protein	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	4.00165e-45
NZ_CP022961.1|WP_095565669.1|3929991_3931638_-|hypothetical-protein	gnl|CDD|227721	COG5434, PGU1, Endopygalactorunase [Cell envelope biogenesis, outer membrane].	0.00121054
NZ_CP022961.1|WP_095565665.1|3925367_3926366_-|aldo/keto-reductase	gnl|CDD|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	2.12758e-127
NZ_CP022961.1|WP_095565664.1|3924541_3925189_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.37619e-20
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.62384e-18
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	2.80672e-62

Protein sequences

>NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2
MFVVLVYDTAVERNPNALRTCRQYLHWVQRSVFEGELSTAQHRSLMTALRQQLDLGHDSVRVYRIGSPHLVQVDALGTELGNSDSVL
>NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MSASGQSYWLTEPCRIRREDNSIRIERADRTPVRIPITDIRDLVVFDNADINTAAVSLLSRHRITVHLLDHYGNYAGALTPAEDMSSAHVVRAQVTLTADPVARLAVARALVGATAANVAWALDTDLLAGPLERLPAQVRACADAEELMGIEGNFRRTAWGVLDTLLPPWLRLGGRSRRPPSNAGNAFISYLNAITYARVLTAIRCTPLHPAIGFLHADSDRRRNTLALDLAEPFKPLLAERLLRRAAAQRTLTAADFVSDVRSASLSTAGRKKVSIMVREELATTVHHRQLKRKVSYEELIHLEALKLVRLCLEGTPYKPFRPWW
>NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein
MGGVHIKYLLHCPRQLWLYSHGYRPEARNEAVAFGEVVDDTTYRRHHDIDLGAAKIDWVTRGAVVHETKSSRQPSPQHEAQVRHYCLLLARRGVNVRGGVVHYPLIRRTTRVAWDDTARRAAETAEAQARQVSAAATPPPRLPRASCRGCSYRDYCWGDS
>NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3
MAAGPAQNPAQDRILDEVWAKSVDRSGRTGRVGRAERLTEHSRATWVAAGTIADRIGSAGVLAGWSSFWPLVTLAALLHDAGKVAEGFQRQVKLRGHRWGERHEVLSLAYVELLAGGLPPADLALLLAGVGLHHRCLRSESGSGALRDLYPESAAWERIFGYHPDPPPGQPNGQVPAPRHRALLAWYAGQLGLAVPQDGQRRLWQRARDQFARLRVAWDAPVDPERGLVAVLFQGAVTLADHSASAHVPLQTHLPLRPDYLAGFGRRPYPHQERAAATDGHLVLVAPTGSGKTEAGLGWAARQLPAMPGRPRVVWVLPYRASIDAAATRFAQDLRPAPGQAGAPGGASAEAEAEAGADIGVLHGSAALSVLADATEDDCVPTAADARGAGARAGAMRLFAQRFRVATVYQLLIGAVAGPRYASVLLEQANSLIVLDELHAYDPQTFGRICAAMRLWEELGSRVAVVSATLAPPMVELIRETLRHPVSVHRAAAGTAPDRHRLVLDERPLTDPSSLAVIREWLADGYSVLLVANTVATAQELYRVLAPEVDPADPDATLLLHSRFRARDRAAIERRLLARHGERRPGQSARRGGLVVATQAVEVSLRLDFDRGATELAPIEAVAQRAGRVNRLGHHPEGAVPYRVHRGERPHPYPPDALDAAWSALNDAPGPVMSEQTVDHWLTLAYRTDWGRRWAEQARHSRDAFGETFLTFTEPFTDRTEFLDGLRESFDTVEVLLEADRQEYARLTAGPDGHALLGAGLLIPISYRQWHTLDRTGTIGRGIPVVDAPYSPEHGLDPDGTHRTTTPLPSAEDTVL
>NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5
MPSGTTTTGPPGGGGPVEATRIELFAPVASFRDPMFPGLTRCLPVPPSSALRGMLAAATGAAAEPVPLGYSARAAGTGVDAETYHPIAADGANPAVAGRVRAVKGGTTVKDRPFLAHLSVTLWIPEPDGTRIAAALRRPVWGLRLGRSQDLVYVRSVSPVLLRPADVAVVGHALAPPGGHDAGAAVTVRLAEWIAADRLTTRYGDYLWCAEPAGRLPVRHALRDGDRAVWLRPAPAGPGQR
>NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MAYLAGKLVLAVTAGAPNNGRGEATTGRVKQTRIRQHIYPYVSAQAARRWLRDTMTEQGAVPSPTERVGRKQSKAQKATTEADPLRYVDDDLFGFMKATAKSEDADTTLRDSPFMIGTLLSVEPARPTEDFGVMARGIDDPVLHAHEFYTADLAAPFLIDLPRIGTFTTPNERGAGKANYLTREAALAVAEAVNAGAETVLFRGQPAVRLPLQTRRERAALLLEALSELSGGAKKGLHYGDRTPTLLMLLAMEGGVNPLEFAVGGADDGSGLQVRGDVLRAELEAWDGRWQPPVRVGWRPGFRDVERKQFEADVAGEIDAGTVTVQHPRTMLRTLAAELRAGVHDAWFDDPAR
>NZ_CP022961.1|WP_095565656.1|3913457_3914861_+|hypothetical-protein
MGLSTTVAPPALALTAHPLQRCGAWAVAVLAGRDEPGELTPDDLDTVAGRLVDDVVTASTKPKKPEPDWWKVLFALYPNAKPTHAKRSRDPDTLRPAVVALFAADQPGPTALPCAFCSAPATVLWAKSHLPMFDTPHAVNNLPPGTAGWPVCRGCRIALWALPYGAWLTAGSATVLMCANPAVERRFVDRNVTRARRIQQVGFTGVPVDAGAEAVALAALRAHAADAPADAVLWSFKNDNKSPWLKVSATRQAIARLLVRIESDRATRRGWRRLRRALAGRNRDRRGHAAIARTLFAGEPGPVDRLLRALQHEFTDPPNDPATTDGWRRLARAYQEEMYGMDVERLAPARRLVAAWIMAERNPRGRFNEYAKVAGKGYDLHRLLMEAGARLLRDGGQPPDISGVAPALLSGGPDSWRWRAQLFFEVVADLVEARAAIGRKPDEPDGDEDEDDATIRFDPNEMEEEYA
>NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6
MRFYVDVAGPDAALPWKHVHGVAHAVVYGLLGDQAPDLATDLHDHGWNGTGLRPIGITPPAFTGARRKPGAFMMSTNGRIWFGSPVPELAALLLTGVTSRRELRWGPVTLTVKGAQLEPVGGAETPAVLETRTPILIKAEGDRYLLPEDDGYTERLLANIRRKAKALGVPGDADLEVLDAGKRRRYDVCGGIRIGATAKIRLHADPRLVDALREWGLGLATIEGFGWVR
>NZ_CP022961.1|WP_157756809.1|3908074_3908740_+|hypothetical-protein
MTTGRDGAVLHAVRAAHPLRAAESLAWFTPGTPPGKEIVGYTLSARAAVWLRVGPDGTVQAVDGDPLAEAYEMLLFDGDRELRWLRTPDGLGRAVAVGEDPASLPPGDDVTVDQRPGRDLAAATPRRGDTQRRLLAGEAREHERTGWTALAGRRMATVALPMPFPGTGRWIAVETVEYLVEDGHGNLDVADSRTCRLLPLDEAQTLVRTAPASTHAERTTA
>NZ_CP022961.1|WP_095565653.1|3906398_3908078_+|hypothetical-protein
MGQSTGERIEILGTLVCVGPVHVGGWDTTAEASLTVARDGTGRVCLPGTSIAGSLRAYLGGIHRFGGTAPNDPANALFGTVVPDSRDGSPSWLRVDDAHLIGNDVVPVVRDGVGIDRRSGSAAANFLYTRQLLPAGTRFALRIVADTPTGADAPNYPGGWPRLIDDAVATLVAGLRQGRVPIGAGRGRGLGRVELRDVTVRRADLSDPAGLVGWLAGRTPATGPAPEADPPPDGRLRITVRWKPLGPLLVRDSVAGTVVDTLPLTEMAVDDTVRLLLPGSSIRGTVRAHTERIVRTLRREDAPETFDEALRRPPPGVDVLFGSAPTGRRTDPDGAGTDGAGVDTGGSDSGWRGVLAFADCHSVERVPAEQWNRILAVVPDRVPDGSKAEPREQRQERNTERDRARSALRTTLDKIRLAIPLDVSDHVAIDRWTGGAADHRLFSVLDPAGTVAWDPIQIEVDTARLAASTDSAGATSAPLALPLLLLALRDLRDGWLSLGHGGTRGRGQIQVTEVTFAGDGLVEPWRSLAGNTLDAILADPPPQVEAAMTTWQSTFEEAA
>NZ_CP022961.1|WP_095565660.1|3921600_3921831_+|hypothetical-protein
MDYDQQRRDLVAQGRSNCGRIAISVRGMQSWLVRIAPGTVRQLDEEQFAARLREAAGELIRDQFAGIRVLKSRIYG
>NZ_CP022961.1|WP_095565661.1|3922068_3922695_+|hypothetical-protein
MSLGAIVRNTASQIAYRTTVTLRVSDPQGRTAIDPLNAAQLILEIPIIMPGQQVAVASSAGLRTDLSPAGRPDKVASFDVTLGPTLWLPPENTTLFPTVTTTYLGVDRFDGDPTSGRVRYSVTSTSCRPLVARGSFAVFLDQTGAVVGGAFDPDTTSPHCDAMDHEESLSTIHSIPTGIDEAKTVVSVYCDIATVGGGRVKPSGAPFN
>NZ_CP022961.1|WP_095565663.1|3923940_3924252_+|hypothetical-protein
MKRPPLPIAVASGLILVEAIVFIVFGTPILAALGVLTSAIFIFYTLRGNRQIARLTIISLAIKLLMLIPYWNPLRLFPVVLWTAVTLLFWLPEQSREWFRQND
>NZ_CP022961.1|WP_095565664.1|3924541_3925189_-|class-I-SAM-dependent-methyltransferase
MLDDEVHRATRTAYDAVASTYAQMFRDTLRDSPLDRAVLGAFADLVRAGGNGQVADLGCGPGHITDHLDHLGLAAFGVDASTEMIRLARQAYPKLRFDEGSMTALDIADGALGGVLSRWSVIHTPPAEVPAILAEFHRVLAPGGHLLIGFSATDGPSHPTQVFDHTVAPAHRWWPDHLADLLRRSGLDEVARMVCEPQPTDRRQFQSVHLLARKA
>NZ_CP022961.1|WP_095565665.1|3925367_3926366_-|aldo/keto-reductase
MQTTTLGRTGPAVSTLGLGAMGMSGGYGPADRAESIATVHAALDAGITLIDTGDFYGMGHNELLLAEALRGRDRDSYLLSVKFGGLGGPGGRIGGGYDCRPEAVKNFLAYSLTRLGVDHIDVYRPARLDPAVPIEETVGAIKEAVDAGYVRHVGLSEVDAATVRRAHAVHPVADLQIEYSLLSRAVEADILPTLRELGIGLTAYGVLGRGLISGRWRADQAIRPGDYRGVSPRFAAGNVEHNLALVEALRQVASAKGCTVAQLAIAWVAAQGPQIVPLVGARTRERLAEALPAADLTLSADDLAEIEKAVPRGAARGDRYPSAFMSNLGVGN
>NZ_CP022961.1|WP_095565666.1|3926494_3927364_+|helix-turn-helix-domain-containing-protein
MQRDQLADFLRRRRAAIRPADVGIAEGPRRRTVGLRREEVARLAGMSVDYVVRLEQGRSSQPSTQLLGALARALRLSDDERDHLFHLAGQQPPPSVGTARLARAGLLRLLDLIDDTPAVVLSDLGEVLAQNRASVLLTGDHSGFAGDRRYVAYRWFTEPAARAVHPPAEHERHARQLVADLRAVAGRRPDDPTVNGLVGRLRAASGEFRRLWAEHEVAVRRMDRKTLVHPRVGPLVMDCETLVTPDQGQLLLVLTPADVEARERLDLLRVLGVQEFATRAPRSADARPR
>NZ_CP022961.1|WP_095565667.1|3927437_3928502_-|formylglycine-generating-enzyme-family-protein
MTACCAPGQPGAGTAAAAAAAAAAAAAGGGAAAGGGAAGAGPRTAERAEGDPAARWGFTPPDRDPAQVRRGMVAIPAGTFRMGGDDPDAFPDDGEGPVREVTVSAYHIDPRAVTNAQFAAFVKATGYVTEAERFGWSFVFHQFVRGPARQRVLNAGVPQAPWWLAVQEAQWRHPAGPGSGITDIQNHPVVHVSWQDATAYAAWAGKRLPTEAEWERAARGGLDGARFPWGDEFTPRRQHRCNTWQGEFPHRDTGADGHVGTAPVGAYRPNAFGLYNTSGNVWEWCADWFSPDWHAADRPETRHDPVGPPEGVGRVMRGGSYLCHESYCNRYRVAARTMSGPDSATGHLGFRCAT
>NZ_CP022961.1|WP_095565668.1|3928498_3929995_-|arylsulfatase
MTARPNVVVVLADDMGWGDLGSYGSAIPTPEIDRLAAEGVRATDCHSASAVCTPSRYALMTGRYAWRGPLKNFVLMGHGPALIEPARPTLAAVLHAAGYATGAFGKWHLGLGWRHTDGSVRDAFAPGARLHDDIETDFGRDIDYTAPVTGGPTALGFDRFFGIAGSLDMPPYAFIDQDRTLGVPDREKRTYLTEQRPGRQTEDFDETEVDVRFVAEAVRWIEAQQEPFLCYLAPSAPHRPNVPPAFLRGRSGLGDRADGVCLVDWAVGQLRAALAAKGVLDDTLFIVTSDNGAPTIFTDDGDVTRHRPNGDWRGQKGDLWDGGHREPFLARWPGRLPAGTVVDAPICLTDLLPTVSAATGADVPPGAAEDGRNVLGVLAGTQDGDPDRPIVHHSLGGRFALRRGRWKAIFSAGAGGGFSEPSIGDLFATGSGKAHPAPPWDAGHPDGQLYDVRADPAETDNRWRSEPAVVAEMYDHLRVICGDPSSGLPFDVELGSPA
>NZ_CP022961.1|WP_095565669.1|3929991_3931638_-|hypothetical-protein
MRIRSHTTGRRRLAAIVGTAVLTLVAALLTAAPATANGAPYVGKQYDYGGTVTDINGGLSTVDSIAASITASTAATESAIAAQRATLPYGDITPGAGPALSLYPGPSGVAASNRYAVTVNGQSSFTYQALARKTDTNREEDTSWTSFSFSGSVTVQVTALNQSGLTGCMVRPYAAAIATSYANNVCTFTMSQPRNVSVEFNPNIHNPIAHPMLVFANPPENDVPPATGDPNVRYFGPGVHYLGAGQVLQDNQTIYLAGGAYLQAAFIAPGAVHNLTIKGRGIIDGLFLDTGDQDLNKNQPGIIDIADQSSTNVLIEGITIVNAPRFNVRALAQYTTIENVKTMSWWYSTDGMVGGNKSLLENNFVKSNDDSIKLFWGDTIARKNTIWQLENGASFMISWNLEVDSQNFHVYDNDVIHVEHYFLAKPAVFRALHAGSGTPHRYLFENIRVENANWRLFYLAVENNKWYDPSKGYGELDQLIFRNIHSYSQYSQPNVVRGIDGTHKARNINFVNVYDGANCIWNAGTFDIDPASTNAIRIAKSQDGSCWT
>NZ_CP022961.1|WP_157756810.1|3931663_3933115_-|sulfatase-like-hydrolase/transferase
MTRPNIILIISDQLRRQALGCYGDPNVSTPNIDALAASGTRFTAASSTYPVCVPFRFSLMTGEYAHTRFIPSIEWRMSPAERTLADEFNEADYRTALFGKWHLYGNFGHYPGHNVVKASRTPVPRPFQGRFQHFAGFDICNDPYDTWYSTHDDPTMRKIEGYQTDGLFDLAIDYATGGPAGATGAGSATGDGTAGQREPFAAVLSVEPPHPLFTAPPEYLDRWRDRELVLRDNVEVDKEYRKRGPHGRDLLDDLRVYYAMIENLDDNVGRLVAALRASGQLDNTIIALTADHGELLGCHGVLAKQRPWEESIGIPLIIGNVGGGGRTVADPVCTEDLFPTLLGLAGITPRDPKPGLNLAPVARGQAEGLDRDAVLLEFVAEMRPEVPFHEETWRGIRTRRHKYTVLGDAHGGKPWQFFDLESDPYELTNLVDDPDHADLVKQHHELLRARLAESYDHYVLAPAFGCPGLNTWDPKAEHQKRFG

Crispr_ID: NZ_CP022961_19

• CRISPR_ID: NZ_CP022961_19
• CRISPR_location: 3922852-3923556
• CRISPR_type: Unclear
• Repeat_type: NA:?
• Spacer_info: 10 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7,cas6

Consensus repeat of NZ_CP022961_19

Consensus_repeat	Method
GTTGCGATCCC------TCCAGGGGTGAT-GGGCGAC	PILER-CR
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CRISPRCasFinder
CCCATCACCCCTGGAGGGATCGCAAC	CRT

spacers of NZ_CP022961_19

>19.1|3922882|35|NZ_CP022961|PILER-CR,CRISPRCasFinder
TCCAACGTCTCAACCGCGTCAACAGACGCAGCAAG
>19.2|3922947|38|NZ_CP022961|PILER-CR,CRISPRCasFinder
GCACCCTGGTCTACGACGATCCGGCCACCCACCGGCTG
>19.3|3923015|35|NZ_CP022961|PILER-CR,CRISPRCasFinder
CCCAACCCAACATGGCCGGCATGCTCGCCACGCTG
>19.4|3923080|38|NZ_CP022961|PILER-CR,CRISPRCasFinder
CGGACCGGTTCGCCGTGGTGGAAGTCGTGGAGGAGGAG
>19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder
CCCATCGCCTCGGCGACGTCACCGCCGAGAGTGA
>19.6|3923212|39|NZ_CP022961|PILER-CR,CRISPRCasFinder
ATGTGCACCAGCTCCTGCGCCACCCCCACCAGGGGGAAC
>19.7|3923281|39|NZ_CP022961|PILER-CR,CRISPRCasFinder
GGGCTCAGGAGGCGTTGGGCAGGGCGACGCAGCAGGCCG
>19.8|3923350|39|NZ_CP022961|PILER-CR,CRISPRCasFinder
GCGGTGGTGTTGGAGGCGGATGTGTTGGATCAGGCGGCG
>19.9|3923419|39|NZ_CP022961|PILER-CR,CRISPRCasFinder
GCCCTCCGCCCATTCGTCGTTCCAGTTCCGCGACGTCCA
>19.10|3923488|39|NZ_CP022961|CRISPRCasFinder
GCGGTGTACGCGATGAAGTAGCGCATCTGCGCCTCCTCC
>19.11|3922882|39|NZ_CP022961|CRT
TCCAACGTCTCAACCGCGTCAACAGACGCAGCAAGGTCG
>19.12|3922947|42|NZ_CP022961|CRT
GCACCCTGGTCTACGACGATCCGGCCACCCACCGGCTGGTCG
>19.13|3923015|39|NZ_CP022961|CRT
CCCAACCCAACATGGCCGGCATGCTCGCCACGCTGGTCG
>19.14|3923080|42|NZ_CP022961|CRT
CGGACCGGTTCGCCGTGGTGGAAGTCGTGGAGGAGGAGGTCG
>19.15|3923148|38|NZ_CP022961|CRT
CCCATCGCCTCGGCGACGTCACCGCCGAGAGTGAGTCG
>19.16|3923212|43|NZ_CP022961|CRT
ATGTGCACCAGCTCCTGCGCCACCCCCACCAGGGGGAACGTCA
>19.17|3923281|43|NZ_CP022961|CRT
GGGCTCAGGAGGCGTTGGGCAGGGCGACGCAGCAGGCCGGTCA
>19.18|3923350|43|NZ_CP022961|CRT
GCGGTGGTGTTGGAGGCGGATGTGTTGGATCAGGCGGCGGTCA
>19.19|3923419|43|NZ_CP022961|CRT
GCCCTCCGCCCATTCGTCGTTCCAGTTCCGCGACGTCCAGTCG
>19.20|3923488|43|NZ_CP022961|CRT
GCGGTGTACGCGATGAAGTAGCGCATCTGCGCCTCCTCCGTCG

CRISPR arrays and Neighbor proteins around NZ_CP022961_19

CRISPR arrays

The CRISPR arrays of NZ_CP022961_19

>merge|NZ_CP022961|19|3922852-3923556|PILER-CR,CRISPRCasFinder,CRT
GTCACCCATCACCCCTGGAGGGATCGCAACTCCAACGTCTCAACCGCGTCAACAGACGCAGCAAGGTCGCCCATCGCCCCTGGAGGGATCGCAACGCACCCTGGTCTACGACGATCCGGCCACCCACCGGCTGGTCGCCCATCGCCCCTGGAGGGATCGCAACCCCAACCCAACATGGCCGGCATGCTCGCCACGCTGGTCGCCCATCACCCCTGGAGGGATCGCAACCGGACCGGTTCGCCGTGGTGGAAGTCGTGGAGGAGGAGGTCGCCCATCACCCCTGGAGGGATCGCAACCCCATCGCCTCGGCGACGTCACCGCCGAGAGTGAGTCGCCCATCACCCCTGGAGGGATCGCAACATGTGCACCAGCTCCTGCGCCACCCCCACCAGGGGGAACGTCACCCATCACCCCTGGAGGGATCGCAACGGGCTCAGGAGGCGTTGGGCAGGGCGACGCAGCAGGCCGGTCACCCATCACCCCTGGAGGGATCGCAACGCGGTGGTGTTGGAGGCGGATGTGTTGGATCAGGCGGCGGTCACCCATCACCCCTGGAGGGATCGCAACGCCCTCCGCCCATTCGTCGTTCCAGTTCCGCGACGTCCAGTCGCCCATCACCCCTGGAGGGATCGCAACGCGGTGTACGCGATGAAGTAGCGCATCTGCGCCTCCTCCGTCGCCCATCACCCCTGGAGGGATCGCCGC

>NZ_CP022961|19|5|3922852-3923487|PILER-CR
GTCACCCATCACCCCTGGAGGGATCGCAAC	TCCAACGTCTCAACCGCGTCAACAGACGCAGCAAG
GTCGCCCATCGCCCCTGGAGGGATCGCAAC	GCACCCTGGTCTACGACGATCCGGCCACCCACCGGCTG
GTCGCCCATCGCCCCTGGAGGGATCGCAAC	CCCAACCCAACATGGCCGGCATGCTCGCCACGCTG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CGGACCGGTTCGCCGTGGTGGAAGTCGTGGAGGAGGAG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCCATCGCCTCGGCGACGTCACCGCCGAGAGTGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGTGCACCAGCTCCTGCGCCACCCCCACCAGGGGGAAC
GTCACCCATCACCCCTGGAGGGATCGCAAC	GGGCTCAGGAGGCGTTGGGCAGGGCGACGCAGCAGGCCG
GTCACCCATCACCCCTGGAGGGATCGCAAC	GCGGTGGTGTTGGAGGCGGATGTGTTGGATCAGGCGGCG
GTCACCCATCACCCCTGGAGGGATCGCAAC	GCCCTCCGCCCATTCGTCGTTCCAGTTCCGCGACGTCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC

>NZ_CP022961|19|20|3922852-3923556|CRISPRCasFinder
GTCACCCATCACCCCTGGAGGGATCGCAAC	TCCAACGTCTCAACCGCGTCAACAGACGCAGCAAG
GTCGCCCATCGCCCCTGGAGGGATCGCAAC	GCACCCTGGTCTACGACGATCCGGCCACCCACCGGCTG
GTCGCCCATCGCCCCTGGAGGGATCGCAAC	CCCAACCCAACATGGCCGGCATGCTCGCCACGCTG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CGGACCGGTTCGCCGTGGTGGAAGTCGTGGAGGAGGAG
GTCGCCCATCACCCCTGGAGGGATCGCAAC	CCCATCGCCTCGGCGACGTCACCGCCGAGAGTGA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	ATGTGCACCAGCTCCTGCGCCACCCCCACCAGGGGGAAC
GTCACCCATCACCCCTGGAGGGATCGCAAC	GGGCTCAGGAGGCGTTGGGCAGGGCGACGCAGCAGGCCG
GTCACCCATCACCCCTGGAGGGATCGCAAC	GCGGTGGTGTTGGAGGCGGATGTGTTGGATCAGGCGGCG
GTCACCCATCACCCCTGGAGGGATCGCAAC	GCCCTCCGCCCATTCGTCGTTCCAGTTCCGCGACGTCCA
GTCGCCCATCACCCCTGGAGGGATCGCAAC	GCGGTGTACGCGATGAAGTAGCGCATCTGCGCCTCCTCC
GTCGCCCATCACCCCTGGAGGGATCGCCGC

>NZ_CP022961|19|5|3922856-3923556|CRT
CCCATCACCCCTGGAGGGATCGCAAC	TCCAACGTCTCAACCGCGTCAACAGACGCAGCAAGGTCG
CCCATCGCCCCTGGAGGGATCGCAAC	GCACCCTGGTCTACGACGATCCGGCCACCCACCGGCTGGTCG
CCCATCGCCCCTGGAGGGATCGCAAC	CCCAACCCAACATGGCCGGCATGCTCGCCACGCTGGTCG
CCCATCACCCCTGGAGGGATCGCAAC	CGGACCGGTTCGCCGTGGTGGAAGTCGTGGAGGAGGAGGTCG
CCCATCACCCCTGGAGGGATCGCAAC	CCCATCGCCTCGGCGACGTCACCGCCGAGAGTGAGTCG
CCCATCACCCCTGGAGGGATCGCAAC	ATGTGCACCAGCTCCTGCGCCACCCCCACCAGGGGGAACGTCA
CCCATCACCCCTGGAGGGATCGCAAC	GGGCTCAGGAGGCGTTGGGCAGGGCGACGCAGCAGGCCGGTCA
CCCATCACCCCTGGAGGGATCGCAAC	GCGGTGGTGTTGGAGGCGGATGTGTTGGATCAGGCGGCGGTCA
CCCATCACCCCTGGAGGGATCGCAAC	GCCCTCCGCCCATTCGTCGTTCCAGTTCCGCGACGTCCAGTCG
CCCATCACCCCTGGAGGGATCGCAAC	GCGGTGTACGCGATGAAGTAGCGCATCTGCGCCTCCTCCGTCG
CCCATCACCCCTGGAGGGATCGCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	cas5	cd09693_cas5_CAS-I	gnl|CDD|187824
NZ_CP022961.1|WP_095565667.1|3927437_3928502_-|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl|CDD|335469
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NZ_CP022961.1|WP_095565663.1|3923940_3924252_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565656.1|3913457_3914861_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_157756810.1|3931663_3933115_-|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl|CDD|293758
NZ_CP022961.1|WP_095565664.1|3924541_3925189_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NZ_CP022961.1|WP_095567918.1|3934004_3934820_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP022961.1|WP_095565665.1|3925367_3926366_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|381302
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl|CDD|187818
NZ_CP022961.1|WP_095565666.1|3926494_3927364_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|375319
NZ_CP022961.1|WP_095565669.1|3929991_3931638_-|hypothetical-protein	unknown	unknown	gnl|CDD|227721
NZ_CP022961.1|WP_095565660.1|3921600_3921831_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565661.1|3922068_3922695_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565668.1|3928498_3929995_-|arylsulfatase	unknown	unknown	gnl|CDD|293762
NZ_CP022961.1|WP_095567917.1|3933111_3933993_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|224124
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	3.2e-21	70.1	0.0
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	5.1e-61	201.2	0.0
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	cas5	cd09693_cas5_CAS-I	1e-19	65.8	1.6
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	2.7e-96	317.2	0.0
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	6e-57	188.1	0.0
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	5e-14	47.8	0.0
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	7.6e-42	137.9	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.97781e-24
NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5	gnl|CDD|187824	cd09693, Cas5_I, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	6.81302e-17
NZ_CP022961.1|WP_095567918.1|3934004_3934820_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.93945e-72
NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.57729e-134
NZ_CP022961.1|WP_095565668.1|3928498_3929995_-|arylsulfatase	gnl|CDD|293762	cd16143, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	2.28269e-169
NZ_CP022961.1|WP_157756810.1|3931663_3933115_-|sulfatase-like-hydrolase/transferase	gnl|CDD|293758	cd16034, sulfatase_like, uncharacterized sulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	2.34378e-159
NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.06943e-52
NZ_CP022961.1|WP_095565667.1|3927437_3928502_-|formylglycine-generating-enzyme-family-protein	gnl|CDD|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.00591e-79
NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl|CDD|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	2.70279e-63
NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.62384e-18
NZ_CP022961.1|WP_095565669.1|3929991_3931638_-|hypothetical-protein	gnl|CDD|227721	COG5434, PGU1, Endopygalactorunase [Cell envelope biogenesis, outer membrane].	0.00121054
NZ_CP022961.1|WP_095565665.1|3925367_3926366_-|aldo/keto-reductase	gnl|CDD|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	2.12758e-127
NZ_CP022961.1|WP_095567917.1|3933111_3933993_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.81324e-72
NZ_CP022961.1|WP_095565664.1|3924541_3925189_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.37619e-20
NZ_CP022961.1|WP_095565666.1|3926494_3927364_+|helix-turn-helix-domain-containing-protein	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	4.00165e-45
NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	2.80672e-62

Protein sequences

>NZ_CP022961.1|WP_095565661.1|3922068_3922695_+|hypothetical-protein
MSLGAIVRNTASQIAYRTTVTLRVSDPQGRTAIDPLNAAQLILEIPIIMPGQQVAVASSAGLRTDLSPAGRPDKVASFDVTLGPTLWLPPENTTLFPTVTTTYLGVDRFDGDPTSGRVRYSVTSTSCRPLVARGSFAVFLDQTGAVVGGAFDPDTTSPHCDAMDHEESLSTIHSIPTGIDEAKTVVSVYCDIATVGGGRVKPSGAPFN
>NZ_CP022961.1|WP_095565660.1|3921600_3921831_+|hypothetical-protein
MDYDQQRRDLVAQGRSNCGRIAISVRGMQSWLVRIAPGTVRQLDEEQFAARLREAAGELIRDQFAGIRVLKSRIYG
>NZ_CP022961.1|WP_095565659.1|3920700_3920964_+|CRISPR-associated-endonuclease-Cas2
MFVVLVYDTAVERNPNALRTCRQYLHWVQRSVFEGELSTAQHRSLMTALRQQLDLGHDSVRVYRIGSPHLVQVDALGTELGNSDSVL
>NZ_CP022961.1|WP_095565658.1|3919716_3920697_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MSASGQSYWLTEPCRIRREDNSIRIERADRTPVRIPITDIRDLVVFDNADINTAAVSLLSRHRITVHLLDHYGNYAGALTPAEDMSSAHVVRAQVTLTADPVARLAVARALVGATAANVAWALDTDLLAGPLERLPAQVRACADAEELMGIEGNFRRTAWGVLDTLLPPWLRLGGRSRRPPSNAGNAFISYLNAITYARVLTAIRCTPLHPAIGFLHADSDRRRNTLALDLAEPFKPLLAERLLRRAAAQRTLTAADFVSDVRSASLSTAGRKKVSIMVREELATTVHHRQLKRKVSYEELIHLEALKLVRLCLEGTPYKPFRPWW
>NZ_CP022961.1|WP_095567915.1|3919237_3919720_+|Dna2/Cas4-domain-containing-protein
MGGVHIKYLLHCPRQLWLYSHGYRPEARNEAVAFGEVVDDTTYRRHHDIDLGAAKIDWVTRGAVVHETKSSRQPSPQHEAQVRHYCLLLARRGVNVRGGVVHYPLIRRTTRVAWDDTARRAAETAEAQARQVSAAATPPPRLPRASCRGCSYRDYCWGDS
>NZ_CP022961.1|WP_095567913.1|3916724_3919175_+|CRISPR-associated-helicase/endonuclease-Cas3
MAAGPAQNPAQDRILDEVWAKSVDRSGRTGRVGRAERLTEHSRATWVAAGTIADRIGSAGVLAGWSSFWPLVTLAALLHDAGKVAEGFQRQVKLRGHRWGERHEVLSLAYVELLAGGLPPADLALLLAGVGLHHRCLRSESGSGALRDLYPESAAWERIFGYHPDPPPGQPNGQVPAPRHRALLAWYAGQLGLAVPQDGQRRLWQRARDQFARLRVAWDAPVDPERGLVAVLFQGAVTLADHSASAHVPLQTHLPLRPDYLAGFGRRPYPHQERAAATDGHLVLVAPTGSGKTEAGLGWAARQLPAMPGRPRVVWVLPYRASIDAAATRFAQDLRPAPGQAGAPGGASAEAEAEAGADIGVLHGSAALSVLADATEDDCVPTAADARGAGARAGAMRLFAQRFRVATVYQLLIGAVAGPRYASVLLEQANSLIVLDELHAYDPQTFGRICAAMRLWEELGSRVAVVSATLAPPMVELIRETLRHPVSVHRAAAGTAPDRHRLVLDERPLTDPSSLAVIREWLADGYSVLLVANTVATAQELYRVLAPEVDPADPDATLLLHSRFRARDRAAIERRLLARHGERRPGQSARRGGLVVATQAVEVSLRLDFDRGATELAPIEAVAQRAGRVNRLGHHPEGAVPYRVHRGERPHPYPPDALDAAWSALNDAPGPVMSEQTVDHWLTLAYRTDWGRRWAEQARHSRDAFGETFLTFTEPFTDRTEFLDGLRESFDTVEVLLEADRQEYARLTAGPDGHALLGAGLLIPISYRQWHTLDRTGTIGRGIPVVDAPYSPEHGLDPDGTHRTTTPLPSAEDTVL
>NZ_CP022961.1|WP_095567914.1|3915972_3916698_+|CRISPR-associated-protein-Cas5
MPSGTTTTGPPGGGGPVEATRIELFAPVASFRDPMFPGLTRCLPVPPSSALRGMLAAATGAAAEPVPLGYSARAAGTGVDAETYHPIAADGANPAVAGRVRAVKGGTTVKDRPFLAHLSVTLWIPEPDGTRIAAALRRPVWGLRLGRSQDLVYVRSVSPVLLRPADVAVVGHALAPPGGHDAGAAVTVRLAEWIAADRLTTRYGDYLWCAEPAGRLPVRHALRDGDRAVWLRPAPAGPGQR
>NZ_CP022961.1|WP_095565657.1|3914860_3915922_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MAYLAGKLVLAVTAGAPNNGRGEATTGRVKQTRIRQHIYPYVSAQAARRWLRDTMTEQGAVPSPTERVGRKQSKAQKATTEADPLRYVDDDLFGFMKATAKSEDADTTLRDSPFMIGTLLSVEPARPTEDFGVMARGIDDPVLHAHEFYTADLAAPFLIDLPRIGTFTTPNERGAGKANYLTREAALAVAEAVNAGAETVLFRGQPAVRLPLQTRRERAALLLEALSELSGGAKKGLHYGDRTPTLLMLLAMEGGVNPLEFAVGGADDGSGLQVRGDVLRAELEAWDGRWQPPVRVGWRPGFRDVERKQFEADVAGEIDAGTVTVQHPRTMLRTLAAELRAGVHDAWFDDPAR
>NZ_CP022961.1|WP_095565656.1|3913457_3914861_+|hypothetical-protein
MGLSTTVAPPALALTAHPLQRCGAWAVAVLAGRDEPGELTPDDLDTVAGRLVDDVVTASTKPKKPEPDWWKVLFALYPNAKPTHAKRSRDPDTLRPAVVALFAADQPGPTALPCAFCSAPATVLWAKSHLPMFDTPHAVNNLPPGTAGWPVCRGCRIALWALPYGAWLTAGSATVLMCANPAVERRFVDRNVTRARRIQQVGFTGVPVDAGAEAVALAALRAHAADAPADAVLWSFKNDNKSPWLKVSATRQAIARLLVRIESDRATRRGWRRLRRALAGRNRDRRGHAAIARTLFAGEPGPVDRLLRALQHEFTDPPNDPATTDGWRRLARAYQEEMYGMDVERLAPARRLVAAWIMAERNPRGRFNEYAKVAGKGYDLHRLLMEAGARLLRDGGQPPDISGVAPALLSGGPDSWRWRAQLFFEVVADLVEARAAIGRKPDEPDGDEDEDDATIRFDPNEMEEEYA
>NZ_CP022961.1|WP_095565655.1|3911451_3912141_+|CRISPR-associated-endoribonuclease-Cas6
MRFYVDVAGPDAALPWKHVHGVAHAVVYGLLGDQAPDLATDLHDHGWNGTGLRPIGITPPAFTGARRKPGAFMMSTNGRIWFGSPVPELAALLLTGVTSRRELRWGPVTLTVKGAQLEPVGGAETPAVLETRTPILIKAEGDRYLLPEDDGYTERLLANIRRKAKALGVPGDADLEVLDAGKRRRYDVCGGIRIGATAKIRLHADPRLVDALREWGLGLATIEGFGWVR
>NZ_CP022961.1|WP_095565663.1|3923940_3924252_+|hypothetical-protein
MKRPPLPIAVASGLILVEAIVFIVFGTPILAALGVLTSAIFIFYTLRGNRQIARLTIISLAIKLLMLIPYWNPLRLFPVVLWTAVTLLFWLPEQSREWFRQND
>NZ_CP022961.1|WP_095565664.1|3924541_3925189_-|class-I-SAM-dependent-methyltransferase
MLDDEVHRATRTAYDAVASTYAQMFRDTLRDSPLDRAVLGAFADLVRAGGNGQVADLGCGPGHITDHLDHLGLAAFGVDASTEMIRLARQAYPKLRFDEGSMTALDIADGALGGVLSRWSVIHTPPAEVPAILAEFHRVLAPGGHLLIGFSATDGPSHPTQVFDHTVAPAHRWWPDHLADLLRRSGLDEVARMVCEPQPTDRRQFQSVHLLARKA
>NZ_CP022961.1|WP_095565665.1|3925367_3926366_-|aldo/keto-reductase
MQTTTLGRTGPAVSTLGLGAMGMSGGYGPADRAESIATVHAALDAGITLIDTGDFYGMGHNELLLAEALRGRDRDSYLLSVKFGGLGGPGGRIGGGYDCRPEAVKNFLAYSLTRLGVDHIDVYRPARLDPAVPIEETVGAIKEAVDAGYVRHVGLSEVDAATVRRAHAVHPVADLQIEYSLLSRAVEADILPTLRELGIGLTAYGVLGRGLISGRWRADQAIRPGDYRGVSPRFAAGNVEHNLALVEALRQVASAKGCTVAQLAIAWVAAQGPQIVPLVGARTRERLAEALPAADLTLSADDLAEIEKAVPRGAARGDRYPSAFMSNLGVGN
>NZ_CP022961.1|WP_095565666.1|3926494_3927364_+|helix-turn-helix-domain-containing-protein
MQRDQLADFLRRRRAAIRPADVGIAEGPRRRTVGLRREEVARLAGMSVDYVVRLEQGRSSQPSTQLLGALARALRLSDDERDHLFHLAGQQPPPSVGTARLARAGLLRLLDLIDDTPAVVLSDLGEVLAQNRASVLLTGDHSGFAGDRRYVAYRWFTEPAARAVHPPAEHERHARQLVADLRAVAGRRPDDPTVNGLVGRLRAASGEFRRLWAEHEVAVRRMDRKTLVHPRVGPLVMDCETLVTPDQGQLLLVLTPADVEARERLDLLRVLGVQEFATRAPRSADARPR
>NZ_CP022961.1|WP_095565667.1|3927437_3928502_-|formylglycine-generating-enzyme-family-protein
MTACCAPGQPGAGTAAAAAAAAAAAAAGGGAAAGGGAAGAGPRTAERAEGDPAARWGFTPPDRDPAQVRRGMVAIPAGTFRMGGDDPDAFPDDGEGPVREVTVSAYHIDPRAVTNAQFAAFVKATGYVTEAERFGWSFVFHQFVRGPARQRVLNAGVPQAPWWLAVQEAQWRHPAGPGSGITDIQNHPVVHVSWQDATAYAAWAGKRLPTEAEWERAARGGLDGARFPWGDEFTPRRQHRCNTWQGEFPHRDTGADGHVGTAPVGAYRPNAFGLYNTSGNVWEWCADWFSPDWHAADRPETRHDPVGPPEGVGRVMRGGSYLCHESYCNRYRVAARTMSGPDSATGHLGFRCAT
>NZ_CP022961.1|WP_095565668.1|3928498_3929995_-|arylsulfatase
MTARPNVVVVLADDMGWGDLGSYGSAIPTPEIDRLAAEGVRATDCHSASAVCTPSRYALMTGRYAWRGPLKNFVLMGHGPALIEPARPTLAAVLHAAGYATGAFGKWHLGLGWRHTDGSVRDAFAPGARLHDDIETDFGRDIDYTAPVTGGPTALGFDRFFGIAGSLDMPPYAFIDQDRTLGVPDREKRTYLTEQRPGRQTEDFDETEVDVRFVAEAVRWIEAQQEPFLCYLAPSAPHRPNVPPAFLRGRSGLGDRADGVCLVDWAVGQLRAALAAKGVLDDTLFIVTSDNGAPTIFTDDGDVTRHRPNGDWRGQKGDLWDGGHREPFLARWPGRLPAGTVVDAPICLTDLLPTVSAATGADVPPGAAEDGRNVLGVLAGTQDGDPDRPIVHHSLGGRFALRRGRWKAIFSAGAGGGFSEPSIGDLFATGSGKAHPAPPWDAGHPDGQLYDVRADPAETDNRWRSEPAVVAEMYDHLRVICGDPSSGLPFDVELGSPA
>NZ_CP022961.1|WP_095565669.1|3929991_3931638_-|hypothetical-protein
MRIRSHTTGRRRLAAIVGTAVLTLVAALLTAAPATANGAPYVGKQYDYGGTVTDINGGLSTVDSIAASITASTAATESAIAAQRATLPYGDITPGAGPALSLYPGPSGVAASNRYAVTVNGQSSFTYQALARKTDTNREEDTSWTSFSFSGSVTVQVTALNQSGLTGCMVRPYAAAIATSYANNVCTFTMSQPRNVSVEFNPNIHNPIAHPMLVFANPPENDVPPATGDPNVRYFGPGVHYLGAGQVLQDNQTIYLAGGAYLQAAFIAPGAVHNLTIKGRGIIDGLFLDTGDQDLNKNQPGIIDIADQSSTNVLIEGITIVNAPRFNVRALAQYTTIENVKTMSWWYSTDGMVGGNKSLLENNFVKSNDDSIKLFWGDTIARKNTIWQLENGASFMISWNLEVDSQNFHVYDNDVIHVEHYFLAKPAVFRALHAGSGTPHRYLFENIRVENANWRLFYLAVENNKWYDPSKGYGELDQLIFRNIHSYSQYSQPNVVRGIDGTHKARNINFVNVYDGANCIWNAGTFDIDPASTNAIRIAKSQDGSCWT
>NZ_CP022961.1|WP_157756810.1|3931663_3933115_-|sulfatase-like-hydrolase/transferase
MTRPNIILIISDQLRRQALGCYGDPNVSTPNIDALAASGTRFTAASSTYPVCVPFRFSLMTGEYAHTRFIPSIEWRMSPAERTLADEFNEADYRTALFGKWHLYGNFGHYPGHNVVKASRTPVPRPFQGRFQHFAGFDICNDPYDTWYSTHDDPTMRKIEGYQTDGLFDLAIDYATGGPAGATGAGSATGDGTAGQREPFAAVLSVEPPHPLFTAPPEYLDRWRDRELVLRDNVEVDKEYRKRGPHGRDLLDDLRVYYAMIENLDDNVGRLVAALRASGQLDNTIIALTADHGELLGCHGVLAKQRPWEESIGIPLIIGNVGGGGRTVADPVCTEDLFPTLLGLAGITPRDPKPGLNLAPVARGQAEGLDRDAVLLEFVAEMRPEVPFHEETWRGIRTRRHKYTVLGDAHGGKPWQFFDLESDPYELTNLVDDPDHADLVKQHHELLRARLAESYDHYVLAPAFGCPGLNTWDPKAEHQKRFG
>NZ_CP022961.1|WP_095567917.1|3933111_3933993_-|carbohydrate-ABC-transporter-permease
MRPPASASAPAPDTAPPARRPRRGRGLFPAYLVLVVLALFAIGPLVALLFNAFKNNAQIGASPLTPPSSLSLTNFTEAWTRGDFAVTMKNSAILCVGTVAGTCVIAGMAAYALSHLRVPGGNGVLAYLFLGSSLPVQLFVVPLFFLWTELRLTDSLFGLMIIYWAVDAPFATLLLRSFLVKVPTDFVEAARLDGASDAQIARRVVLPLAWPGFLTVGLIAGLMAWNEFFWAITFIHDPSKRPISTSFLAFQDQHSTDWGLTSAAALFMLLPVVILFLALQRRFVAGLTSGGLK
>NZ_CP022961.1|WP_095567918.1|3934004_3934820_-|sugar-ABC-transporter-permease
MAPLLLLNGLVVIGPSVATVYYSLTDWSGLGPATFIGLDNYVRAFGDDKVHAALWHNTVWFVLFLSVPMAMGLLGAHLLSQVRRFQMLFRALYFIPYVVASVVNAAVWKMLLSPTSGLGHVLGIDQAWLGDPATSLLSVNFVVNWHWWGFLAVIFFAAMQGVDPQLYDAAKVDGANGWQRFRSVTLPGIRPTVVFILLMTVIWTLKAFDYIFIMTEGGPAGSSEVMATLMYKQAFNEYSAGYAAALGLSMTVVTAMVLAVYQILRKRGWET

Crispr_ID: NZ_CP022961_20

• CRISPR_ID: NZ_CP022961_20
• CRISPR_location: 3958922-3958990
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas8e,cse2gr11,cas7,cas5,cas6e

Consensus repeat of NZ_CP022961_20

Consensus_repeat	Method
GCGGGCGGCGACCCGGAGGCCGCCGG	CRISPRCasFinder

spacers of NZ_CP022961_20

>20.1|3958948|16|NZ_CP022961|CRISPRCasFinder
CCGTCAGCGCGGCGGT

CRISPR arrays and Neighbor proteins around NZ_CP022961_20

CRISPR arrays

The CRISPR arrays of NZ_CP022961_20

>merge|NZ_CP022961|20|3958922-3958990|CRISPRCasFinder
GACGTCGGCGATCCGGGTGGCGGCGGCCGTCAGCGCGGCGGTGTTGGCGGCGTCGTCGAGACGGCCGGC

>NZ_CP022961|20|21|3958922-3958990|CRISPRCasFinder
GACGTCGGCGATCCGGGTGGCGGCGG	CCGTCAGCGCGGCGGT
GTTGGCGGCGTCGTCGAGACGGCCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl|CDD|187886
NZ_CP022961.1|WP_095565675.1|3942476_3943142_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl|CDD|378050
NZ_CP022961.1|WP_095565687.1|3965058_3967659_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NZ_CP022961.1|WP_157756811.1|3954658_3954826_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_157756812.1|3967675_3968077_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565680.1|3950280_3952386_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223288
NZ_CP022961.1|WP_095565691.1|3969278_3969740_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
NZ_CP022961.1|WP_095565689.1|3967986_3968487_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173812
NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl|CDD|378191
NZ_CP022961.1|WP_095565686.1|3962643_3964896_-|mycodextranase	unknown	unknown	gnl|CDD|271156
NZ_CP022961.1|WP_095565684.1|3959244_3960180_-|DUF2993-domain-containing-protein	unknown	unknown	gnl|CDD|378597
NZ_CP022961.1|WP_095565682.1|3954920_3957005_+|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
NZ_CP022961.1|WP_095567921.1|3953811_3954384_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565681.1|3952604_3953864_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP022961.1|WP_095567922.1|3960370_3961819_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NZ_CP022961.1|WP_095565692.1|3969736_3970345_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NZ_CP022961.1|WP_095565690.1|3968590_3969244_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565685.1|3961861_3962554_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|378189

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	3.7e-29	96.5	1.1
NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	4.4e-48	158.2	1.6
NZ_CP022961.1|WP_095565675.1|3942476_3943142_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	1.6e-62	206.1	0.1
NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	9.3e-116	382.0	0.9
NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	2.4e-115	380.9	0.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	3.37987e-45
NZ_CP022961.1|WP_095565675.1|3942476_3943142_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	6.65083e-76
NZ_CP022961.1|WP_095565687.1|3965058_3967659_-|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.11223e-20
NZ_CP022961.1|WP_095565682.1|3954920_3957005_+|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.55197e-31
NZ_CP022961.1|WP_095565680.1|3950280_3952386_-|DEAD/DEAH-box-helicase	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.56157e-16
NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	1.51673e-163
NZ_CP022961.1|WP_095565689.1|3967986_3968487_-|S8-family-serine-peptidase	gnl|CDD|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.45783e-13
NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	1.08913e-33
NZ_CP022961.1|WP_095565686.1|3962643_3964896_-|mycodextranase	gnl|CDD|271156	cd14490, CBM6-CBM35-CBM36_like_1, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	5.10127e-62
NZ_CP022961.1|WP_095565684.1|3959244_3960180_-|DUF2993-domain-containing-protein	gnl|CDD|378597	pfam11209, DUF2993, Protein of unknown function (DUF2993). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	3.86057e-18
NZ_CP022961.1|WP_095567922.1|3960370_3961819_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	7.06523e-54
NZ_CP022961.1|WP_095565681.1|3952604_3953864_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.64836e-88
NZ_CP022961.1|WP_095565692.1|3969736_3970345_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.55345e-21
NZ_CP022961.1|WP_095565685.1|3961861_3962554_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.53651e-84
NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	1.99541e-124

Protein sequences

>NZ_CP022961.1|WP_095565682.1|3954920_3957005_+|N-6-DNA-methylase
MTTDADAPSGAATLTASGIARLANVGRAAVSNWRRRYADFPAPVGGTPNSPSFDAREVEQWLRRHGRLHHADARHLAWQHIESYQPAAQLTDALTIAGCHLLVRAQKPTGDATPTPKQLLARLRGIDAGIADLVRGALPDRWTPQLTGLLSAVDRLAAEHDPETAFEYLHGRYVTSANPLSGLAGTPDTVAEVMLTLAGSGPDILDFTSGTGSILRMAADQALRRGTDTRCHAQEIKPQYALITLIRLWFVHLRARRNGQPAQPPAVHVGDSLLADAVPGLRADVVVANFPFGIHDWGYDQLAYDPRWAYGLPPRTEPELAWVQHALAHLSPGGTAVVLMPPAAALRPAGRRIRAELVRRGALRAIIALPAGLMPPTGLGLHVWALAQPDPRQPPADRLLVVDTTAATGRQLPDIVGEAWRAHLAGNHVERPGVHRAVPAIEMLDDQVDLTPQRYLPQAGEPSTSPDEIIGRIDELAARLDNVRRGLPALRPTETTALRAVPRADIADLIRSGTIAVHRTTARRQSTPGIGVRPVLTTTDVITGGPPTGTADRAGDDAPEPRVLPGDILMPLTGRRIHARVATPAQVGAEPGPGVQLVRVDPARFDPWFVAGVVSRTGNLRLAGRSTNGTLRIDIRRLSIPVLPLSQQQTYGRIFAGLVEFRSTLDEVASTGAALARDIADALTDGTLEPSTAD
>NZ_CP022961.1|WP_157756811.1|3954658_3954826_-|hypothetical-protein
MPRRGRSTTVGKFAKRHQDQRVSEIRVLGDLLRRERTDGAHPDVPVAPVARPLPA
>NZ_CP022961.1|WP_095567921.1|3953811_3954384_-|hypothetical-protein
MRLDPRVGRLIADAYEAAPASDPRAYRAYAAFCRETVRQYHFLVGRVEFGGLGLTVRIVDEDPYRDADEMVADVRERRLKVWSSAATGNAHPYLSDGENDMFRAVHDAFGHAASGRGFDGDGEEAAWLKHSTMYPPLARRAMTTETRGQNCALIFRYGGGRFPSQKAVLLPGAVSDPGRLIAALTGAGPR
>NZ_CP022961.1|WP_095565681.1|3952604_3953864_+|serine/threonine-protein-kinase
MGEVWPAHDTLLDRPVIVKTVGGLGVDQARRFRREALLTARFDHPGVPAVYDFGEHDGRLYAVIQRIDGVTLADLVNEQGPLPVGWVAAIGAQVGSVLLSARQIGLVHRDIKPSNVMLERSGAVKVLDFGLAVAPADGRYSRITESGQVLGTLGYMAPEQLNGADTDHRTDLYCLGATLFDLLTNQEPFDADSTRTLLERQLTGPPPRPTQLRPDLPAELDDLIHALLAVDPQDRPGSAAEVYDVLAPLACDLRPLPGVLDPASTVRAYAAIVGQVPQPGGVPPAATPLAAAPAPRPGNADAEADGEADGERAVAEAERLEAVGEFRAAARQWRRLASSHASRHGADQPAVFDFRLRAARVHVRLGEHDRAIRQLEALLRDRTELDGPEHPAVRAVRAEIARLTAGRPRSAPRSAGPDH
>NZ_CP022961.1|WP_095565680.1|3950280_3952386_-|DEAD/DEAH-box-helicase
MAELAIERGFLPAYARLERRVQRAVDAAIAKFAEHTHAGIHLEKLTKSRDPHIRTIRVDRFYRGVVLSLGQEKYALLNVLPHEDAIAFAMSRRFTVNQALGVLEMRDQQSIDDFARHTPVEPSGTGLFTGVSTADLVRLGIDEDLVPLLRLIRTEQQFESLAGRLPEVQSDVLSGLASGLPVEEVWAELADRIVSGVDTDDLVTAARRTPERIAFVSGPIELAAILAHPFDVWRTFLHPTQRDVAYRDSYSGPALVTGSAGTGKTVTGLHRAVFLAGRLPDDGTKVLLTTFTRALAEALDRQLYRLADNPAARDRIAVISVDKLAYDIVRRSGQKVGIADDEVLDQLWSAAAKAGPTYVDRAGRVTPFSAAFLRREWEQVILAQQLTTMAAYRDAPRRGRGEALRGAQREQVWAAIEGVVRELAKRRQRTHTQLADEAARIAAGAPSPYRHIVVDEGQDLHPAQWRLLRALVPPGPDDLFLLADPYQRIYDSHVSLGQLGIQVRGRTRRLTVNYRTTHEILDLSVKVLGGDAAVGLDDEGDSLRGYRSVTRGGVPTIVAHPDRHSESEALIEQVGTWLDQGVEPHAIGVAVRTGQLVATLSRTLAEAHIPVADDKCGTDGVKIATMHRMKGLEFQCLAVAGLDAEALPSPYALTPASEDPHAHRQDLQRERCLLFVALTRARDVLYLSHSGTPSSLLPEQR
>NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MPVTGTPLTGTPSQPPGFSLVDEAWIPVLDAAGHRRDVSLPELFALAGDLRMIACELPTQTFAILRLALAILHRSTGGPAGEAAWRALWRDPRLPAGEIADYLGEFRDRFDLLHPQRPFYQVADLRAAKEDRYDLKRLIADVPNGMPFLTTRAGPGMASIPPAEAARWLVHCQAYDPSGIKTGALGDPRVKGGKGYPIGTGSVGALGGVYLEGATLRETLLLNLVPAAPRWQRSDERDLPVWEREPQTATEEPEATRGPYGPLSLYTWQSRRIRLFGTAGGITGAMISNGDRLDWQDRHLTEPMSVWGRSGPREREQKKTPIYLPRPHDHGRALWRGLQTLLPAPPQSGAEPAQRLSPMVVQWLARLTVDGVVGADFRVRPRAVSITYGTQMAVVDEVFSDALTMNVLLLVEDSGLRATAVDAAADADIAVVLLRRLAENLARAAGSRDDAVGDADRAGERGYALLDRAYRDWLARLGPGSDPAAERADWQRLVGRAIRRLGGELVAAAGPAAWIGRTRTDRNGRDVHYSSSQAEAWFHRGLTRALPMATGSEQQGPEQQGPEQQRQEEPV
>NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MTVTETDRPKARGRRRRDLGEHVAGVVGALQARALANPPVPEAVGALARLRRGLGRAPGFDFGLERYLQVPEDLLGYRPADDTQATDSEHAVHDAVTLYALHQQSRRERMHVAGRGLGQALADLVRRSAGPDGVRRRFAALGTASTYPESIYHLRSLTTMLREQQIPLDYGLLADDLRLLRGLDGPAKVQAIWGREFFRSHPGADAGTPGAQASGAGTPDRNPRGTAATSTEEN
>NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MNRTIIDLYALQTVPPSNLNRDDTGSPKTAIYGGVRRARVSSQAWKRAIRLAFADLLDPSQLGERTKRVGESLARRIRALEPELSDEEASALAANVFVTGGLAKLDKKKGELKDVESGYLLFLSHRQLDNLARAALEAERGGAPLDKARFKTLVDTEHSIDIAMFGRMVADMADINVDAACQVAHAISVHGVDNEFDYFTAVDDRKADAAETGAGMIGTIEFNSSTLYRYATVDVDALHETLGDPAATRAAVEAFLTAFARSMPTGKQNTFAHRTLPDAVLVRLRDTQPINLVGAFETPIRETQAAGRIELAAAALARHTAAVENAYGERPVASWVTQVGEQTAVLADLGKSVSFAELVAGVSEQVDVALGQSALGESGFGQPALGQPA
>NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSVLLLRLGGPLQSWGSSSRFARRGTEVAPSKSGVLGLLAAARGMRRTEPLTDLLGLEFGVRLDQPGQVLRDFQTARTLDGRQSAPLTYRFYLSDAVFLAAVGGAPDLLHGLAEALRRPKFPLYLGRRSCPPDGPVSLGVHDLTLDDALTQWPWLATERYRRRAARTERLEIIRDARPGEPVTETVPDTPVSFDPAHRQHTWRSVLRRHVDVSNELVERAGVTEHDPLSLLGG
>NZ_CP022961.1|WP_095565675.1|3942476_3943142_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MFLTRFQINPARRGARRLLSSPQVLHAAVRAGFAAPEDHERDGARTLWRLDSPTPTTVHLYIVSPGRPDLTHLVEQAGWPTTETWVTRDYGPLLDGLRPGQEWAFRLTANPSHSGRKTADAKETQRFGYLREEEQVGWLTGRATRLGFTVATQQDGRPNVRLHRRQTYSFKRGLGTVTLTTATYDGVLRVGDADAFRRSLTGGIGHAKAYGCGLLTLAPAG
>NZ_CP022961.1|WP_095565684.1|3959244_3960180_-|DUF2993-domain-containing-protein
MRWCSGRVPVPLPRRLLPTRRRWTVLIATLSAAALLGGADRVLAAVAAGRLAERLQCAVGTDRRPDVTVHGFPFLAQALTGRYRGLDVTVRDLRHGRLHLASVHASLRDAALTGSTMSVGAARIEAVVPFTALPARIGDRTVSYGASDGLLAITTAVTLVGQSLPVTLLGQPEITDGTLRIEPREVEVLGVRRPAEQLLDRIGLRERPSQALPELPAGLRYASVGVRPDGMMITVTGAGLSVPLRAPGTPAASGSPAASGSPAASGSPAASGSPPASPAASSSFSGTPSVALPVPPAGRPVPSPEPCGAQR
>NZ_CP022961.1|WP_095567922.1|3960370_3961819_-|HAMP-domain-containing-histidine-kinase
MLAVTAVVLLVTGAGTAFALRGYLLARTDDQLDIAARFAQQRLGQLDGVPARGSLQAVIAPSDYLLELRRPDGSLTRMGSLQSVPGRPLLDRAPPAPPDGNLSPATNLADGRYRAVVGRTADGGSVLVALPLEPVRATIRQVLLTEIAVGLAMLLLLAVGGRLLVARGLRPLDRITATATAIADGELDRRVPPGPPERTEVGRLTLAVNGMLARIETALRARAASEDRMRRFVADASHELRTPLTSIRGYLQLLRQGIVGDPDRPEVLRRAEDEARRMGALVDGLLFLARLDAEPALRHEPFDLVAPLRDSVSDLLAVQPGRPARLELPPACRVRGDEDALRQVMANLLANVRVHTPPDVPVTVALRPADGYAEVEVGDRGPGVPAELAGRAFDRFTRGTGTGGGPGGAGGGPGGAGGGPGGAGAGGGGGFGAGGAGSGLGLAIVAEIVAAHGGTIGLDSSQRGTTVRFTLPLADPDPGAAG
>NZ_CP022961.1|WP_095565685.1|3961861_3962554_-|response-regulator-transcription-factor
MREAARVLVVDDQPNIVDMLATVLRFHGFQVSTAGSAAEAVRCAAEHRPDVVVLDVMLPDGDGFDVCRELRAGGHEIGIVFLTARDAPGDKINGLTYGGDDYVTKPFSVDELVARVRAVLRRIRPAAGQPQPGVLRFADVELDEEAIQVRRAGRLVELSPTEFKLLRYFMRHPNRVLSRAQILGEVWSYDFGGTSNVVDTYVGYLRRKLDQHGPTLIATRRGFGYTLTEG
>NZ_CP022961.1|WP_095565686.1|3962643_3964896_-|mycodextranase
MCVVRWHHGRQFSARSGSRPHTRGNATWPGRAAHPGTFHGWAHRTEVVPSPTERKNEASDGPRHRRGTAGPAPRGDHHRHRADHRRGRPGRRTGRRPTPERAGGPGATAATRTGAAGAAPAVTRAALDPALVAGRGARVGFVEQEAENAATDGEVIGPDRAAYTLPAEASGRMAVRLLPGQHVEFTLPAAANAITVRYSIPDAPTGGGSTAPLAVAANGRHLRTMTLTSRYGWLYNQYPFSNDPGAGLLHPDWWITECSCVPADTTPYPSIDTPFRPQHFYDEQRLLLGRTYRAGDRIRLTAPAGSSAAWTVIDLLDSELVAPPRIRLRAVNVLALGADPTGHRDAAPAIERAITLARLAKLPVYLPPGVYQVNRHIVVDDVTIEGAGSWYTLIKGHEVTLSEPAPDGSVHTGVGFYGRDAAEGGSHDVHLSGFAIEGDVRERIDTDQVNGIGGAFSDSTFDGLHIRHTKVGIWLDGPMRNVRITNTMIVDQIADGLNLHTGVTDSLVADTVIRNTGDDGLAMWSEGTGNARNTFAHNTVQSPVLANGIAIYGGTDNTVSDNLVADPVREGSALHVGSRFGAEPFTGTLSITDNTTVRAGTYELNWNIGLGAIWVYALDRDIDARIEVTGDAYLDSTYNAIMLVTEWSVKDLYSISDIHFRDVQVDGTGTSVLSARSAGAASFQNVDARNVGAVGVNNCGSFNFTPAGSEFGLTDLGGNDGGWLADWLLPNTITCDDRPPVVPPPPPAAW
>NZ_CP022961.1|WP_095565687.1|3965058_3967659_-|CHAT-domain-containing-protein
MELQRAAELHERAIAENARGRHALARRLLHQALRNDPDPQRRAHILISLAYHEAERRNLAAGLDLLRAAEAVPRLPRRLRGLAASQRGLLYMRAGQVDEAVEGFSAALRLLDGSAPHDVCRALLNRGILAMQHGGYAAAKADFARCAGLARRNGLDLLGAKAAHNLGYLALLSGDLPRALREMDAVAPSLTGQSPVYAAVYHIDRAQALLAAGLSREADEDLARAVELFRAARVRQDQAEAELARAQVAMLEQRWADARALAARARRRFTDRGAASWALLAAHVSVAARVEQGLRPGSAATEAAGLADQLQAAGLDEDARRARLTAALAALAGPHRGSDRARPDRGSDRAGPERGSDRAGPERGSDRVERAAELAGTALLLRRDDPIGTRLSARLARAALAEARGATAAANRERRAGLADLHRYQASFGSHDLRTAASGHGRRLAADGLGWALSTGRPAEVFQWAERARALSARLAPVLPPADEEAAALLEQLRHARVELRAQALAGRVDPSLRARCRRLEQRIRQRSWYASGAGETTEPAPLHRLCGQLGAADATFVAHLLSGDRLHALVATGRRQTVRDLGPAAAAIETHRQLRHDLDALAVSGLPEQIRATVRSASRAAVRRLDALLWEPVRPLLAGGPLLLAPSADLATVPWTMLPTLRGCPVAVVASVTAWLDRRDCGGLPASPRVALATGPGLARGADEIRLVAKTWSLNPPEEEASTADVRHAARVADVLHIAAHGVHEPDNPLFSHLGLADGPLFGHDLQALGRLPEHVVLSACELGLASTRPGDETLGMTASFLHGGAGSVVAGVARIADAAAYQVAPAHHAALSRGLSPAAALAAATAAVDADADPVPLVCFGAGW
>NZ_CP022961.1|WP_157756812.1|3967675_3968077_-|hypothetical-protein
MGALNPDGRTVALFSNSGPWVTAWQRGAALISTAPVTFQNGLNPLALTADPSGRQRATIDPDSFRSGFAVGTGTSFSAPVFAGCLAARLLSLADAGTLSLDDTSPAAVTRRSMAVDEVAAQDPWPFLSPEPAG
>NZ_CP022961.1|WP_095565689.1|3967986_3968487_-|S8-family-serine-peptidase
MDGVRDALAGHGTFICGLVHQTCPDAQILAIRIIRSDGRIDESDLIRALDQVYELARRHAAGEPNGRPVDIVSLSLGYYHELPEDLEYDSVLLEVLDRLAGLGIVVVASAGNDATTRLMFPAAFSTRSDPARAPLAGWGRSTRTAGPWRCSATAVRGSPPGSVAPL
>NZ_CP022961.1|WP_095565690.1|3968590_3969244_-|hypothetical-protein
MSAAYKPSDDERSLGDADPLLPPPGVLSRYGARVLDPASAVQLPGQRLRPTAYLADRLLVRSDAVGEVRELLDEAAKRLNLTVEFEQRDGKGYPVSGLLARLAPGERPAVVDAWQVLQEARAAARERGTTLRGVGLDHLMFGTTAVSGNPYHEANPYHEANPYHEANPYGAPATQYADPAFGGTRPVAVMLPRPRGAGSTGRRWWRSWTPVAASIRG
>NZ_CP022961.1|WP_095565691.1|3969278_3969740_-|hypothetical-protein
MNSDDRALLAELRSMWETADPVPADLATRALFLLELDDLDVELMSPSQELATAGARGAESISTITFASDQLTVMVTISHSGPQRHRLDGWLAPGVALRVDLRAGSEVRENVADANGRFVFTDVPSGFFQLVIHPTDHPAVRLTRPLVTPATQL
>NZ_CP022961.1|WP_095565692.1|3969736_3970345_-|sigma-70-family-RNA-polymerase-sigma-factor
MTRGMLEGATVDGLTDAWDTAARDFAAWRTGDRAGLDRLVRQMTPVLWHIARAYGLDPQTAEDAVQTTWLALVRNADSVRDPQAVWRWATTTVRREAWRLARAQRQEDAADPARLNEIGPVVPGPEEQVLSDDAARSLWQQVARLPERCRRLLRVIAFDDRPDYATLSNQLAIPIGSIGPTRGRCLDKLRRALAGDPRRRAR

Crispr_ID: NZ_CP022961_21

• CRISPR_ID: NZ_CP022961_21
• CRISPR_location: 3959354-3959433
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas8e,cse2gr11,cas7,cas5

Consensus repeat of NZ_CP022961_21

Consensus_repeat	Method
GCGGGCGGCGACCCGGAGGCCGCCGG	CRISPRCasFinder

spacers of NZ_CP022961_21

>21.1|3959380|28|NZ_CP022961|CRISPRCasFinder
CGACCCGGAGGCGGCCGGCGACCCGGAG

CRISPR arrays and Neighbor proteins around NZ_CP022961_21

CRISPR arrays

The CRISPR arrays of NZ_CP022961_21

>merge|NZ_CP022961|21|3959354-3959433|CRISPRCasFinder
GCGGGCGGCGACCCGGAGGCCGCCGGCGACCCGGAGGCGGCCGGCGACCCGGAGGCGGCCGGCGACCCGGAGGCCGCCGG

>NZ_CP022961|21|22|3959354-3959433|CRISPRCasFinder
GCGGGCGGCGACCCGGAGGCCGCCGG	CGACCCGGAGGCGGCCGGCGACCCGGAG
GCGGCCGGCGACCCGGAGGCCGCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl|CDD|187886
NZ_CP022961.1|WP_095565691.1|3969278_3969740_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565683.1|3957031_3959248_-|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NZ_CP022961.1|WP_095565682.1|3954920_3957005_+|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
NZ_CP022961.1|WP_157756812.1|3967675_3968077_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565680.1|3950280_3952386_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223288
NZ_CP022961.1|WP_095565687.1|3965058_3967659_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
NZ_CP022961.1|WP_095565689.1|3967986_3968487_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173812
NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl|CDD|378191
NZ_CP022961.1|WP_095565686.1|3962643_3964896_-|mycodextranase	unknown	unknown	gnl|CDD|271156
NZ_CP022961.1|WP_095567922.1|3960370_3961819_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NZ_CP022961.1|WP_095567921.1|3953811_3954384_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565681.1|3952604_3953864_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP022961.1|WP_095565692.1|3969736_3970345_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NZ_CP022961.1|WP_157756811.1|3954658_3954826_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565690.1|3968590_3969244_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565693.1|3970772_3972383_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565685.1|3961861_3962554_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|378189

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	3.7e-29	96.5	1.1
NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	4.4e-48	158.2	1.6
NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	9.3e-116	382.0	0.9
NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	2.4e-115	380.9	0.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	3.37987e-45
NZ_CP022961.1|WP_095565683.1|3957031_3959248_-|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	5.31997e-84
NZ_CP022961.1|WP_095565682.1|3954920_3957005_+|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.55197e-31
NZ_CP022961.1|WP_095565680.1|3950280_3952386_-|DEAD/DEAH-box-helicase	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.56157e-16
NZ_CP022961.1|WP_095565687.1|3965058_3967659_-|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.11223e-20
NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	1.51673e-163
NZ_CP022961.1|WP_095565689.1|3967986_3968487_-|S8-family-serine-peptidase	gnl|CDD|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.45783e-13
NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	1.08913e-33
NZ_CP022961.1|WP_095565686.1|3962643_3964896_-|mycodextranase	gnl|CDD|271156	cd14490, CBM6-CBM35-CBM36_like_1, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	5.10127e-62
NZ_CP022961.1|WP_095567922.1|3960370_3961819_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	7.06523e-54
NZ_CP022961.1|WP_095565681.1|3952604_3953864_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.64836e-88
NZ_CP022961.1|WP_095565692.1|3969736_3970345_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.55345e-21
NZ_CP022961.1|WP_095565685.1|3961861_3962554_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.53651e-84
NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	1.99541e-124

Protein sequences

>NZ_CP022961.1|WP_095565683.1|3957031_3959248_-|MMPL-family-transporter
MSTIEDGVLYRLLGRIGRACAGHPLRALAVWALLIAGLVTAVAMAGRPTDNDVDLPGSDAQAARDLIERGDPDAANANAQLVVHIDAGRLDDAANTAALTAAATRIADVEHVVRVVPPSAERGTLSTDGQTGYLTLGFDVQPRNLDQPLADAVVAAAAPARDAGIETVPGGPLAAAADRTNARTSELLGIGAAVVVLLFAFGGLVAAALPIVTALFTLAGALSVIGLAGHLTGIPTVAATLATMVGLGVGIDYALFLVTRHRQQLTLGTPVPEAIAHSVATSGSAVLFAGGTVIIALGGLAVAGVPLLATLAWTTGIAVLFAVAGAVTLLPALLALLGTRVDALRVLPRRAGAGRGGWARLADAVSRRPWRYALAAAILLGTLAAPALDLSLGQIDAGSNPAGSASRRSFDLLGEGFGPGINGPLTVALPLDPPATGPADPRLAALTGAVRAVPGVTQAAPAALTGTSAATVRVTPGTAPGDPGTADLVRDLRAVRVDGVAPHVGGAVATRVDLAQRLGARTPAVIGVVVALSALLLLLAFRAPVVALKAAVMNLVSIGAAYGALTAVFSWGWGLRLLGLDGPVPIESYVPTMLFALLFGLSMDYEVFLLTAIREAWQRTADNTAAVREGLAGTGRVITSAAFIMVVVFASFTLHSDPVIKMFGLGMAVAVAVDATVVRGLLVPATMALLGPVNWWRPARRRAAHSAGPESAGPEPAGPETVSHTPGTAKHPSEVPGV
>NZ_CP022961.1|WP_095565682.1|3954920_3957005_+|N-6-DNA-methylase
MTTDADAPSGAATLTASGIARLANVGRAAVSNWRRRYADFPAPVGGTPNSPSFDAREVEQWLRRHGRLHHADARHLAWQHIESYQPAAQLTDALTIAGCHLLVRAQKPTGDATPTPKQLLARLRGIDAGIADLVRGALPDRWTPQLTGLLSAVDRLAAEHDPETAFEYLHGRYVTSANPLSGLAGTPDTVAEVMLTLAGSGPDILDFTSGTGSILRMAADQALRRGTDTRCHAQEIKPQYALITLIRLWFVHLRARRNGQPAQPPAVHVGDSLLADAVPGLRADVVVANFPFGIHDWGYDQLAYDPRWAYGLPPRTEPELAWVQHALAHLSPGGTAVVLMPPAAALRPAGRRIRAELVRRGALRAIIALPAGLMPPTGLGLHVWALAQPDPRQPPADRLLVVDTTAATGRQLPDIVGEAWRAHLAGNHVERPGVHRAVPAIEMLDDQVDLTPQRYLPQAGEPSTSPDEIIGRIDELAARLDNVRRGLPALRPTETTALRAVPRADIADLIRSGTIAVHRTTARRQSTPGIGVRPVLTTTDVITGGPPTGTADRAGDDAPEPRVLPGDILMPLTGRRIHARVATPAQVGAEPGPGVQLVRVDPARFDPWFVAGVVSRTGNLRLAGRSTNGTLRIDIRRLSIPVLPLSQQQTYGRIFAGLVEFRSTLDEVASTGAALARDIADALTDGTLEPSTAD
>NZ_CP022961.1|WP_157756811.1|3954658_3954826_-|hypothetical-protein
MPRRGRSTTVGKFAKRHQDQRVSEIRVLGDLLRRERTDGAHPDVPVAPVARPLPA
>NZ_CP022961.1|WP_095567921.1|3953811_3954384_-|hypothetical-protein
MRLDPRVGRLIADAYEAAPASDPRAYRAYAAFCRETVRQYHFLVGRVEFGGLGLTVRIVDEDPYRDADEMVADVRERRLKVWSSAATGNAHPYLSDGENDMFRAVHDAFGHAASGRGFDGDGEEAAWLKHSTMYPPLARRAMTTETRGQNCALIFRYGGGRFPSQKAVLLPGAVSDPGRLIAALTGAGPR
>NZ_CP022961.1|WP_095565681.1|3952604_3953864_+|serine/threonine-protein-kinase
MGEVWPAHDTLLDRPVIVKTVGGLGVDQARRFRREALLTARFDHPGVPAVYDFGEHDGRLYAVIQRIDGVTLADLVNEQGPLPVGWVAAIGAQVGSVLLSARQIGLVHRDIKPSNVMLERSGAVKVLDFGLAVAPADGRYSRITESGQVLGTLGYMAPEQLNGADTDHRTDLYCLGATLFDLLTNQEPFDADSTRTLLERQLTGPPPRPTQLRPDLPAELDDLIHALLAVDPQDRPGSAAEVYDVLAPLACDLRPLPGVLDPASTVRAYAAIVGQVPQPGGVPPAATPLAAAPAPRPGNADAEADGEADGERAVAEAERLEAVGEFRAAARQWRRLASSHASRHGADQPAVFDFRLRAARVHVRLGEHDRAIRQLEALLRDRTELDGPEHPAVRAVRAEIARLTAGRPRSAPRSAGPDH
>NZ_CP022961.1|WP_095565680.1|3950280_3952386_-|DEAD/DEAH-box-helicase
MAELAIERGFLPAYARLERRVQRAVDAAIAKFAEHTHAGIHLEKLTKSRDPHIRTIRVDRFYRGVVLSLGQEKYALLNVLPHEDAIAFAMSRRFTVNQALGVLEMRDQQSIDDFARHTPVEPSGTGLFTGVSTADLVRLGIDEDLVPLLRLIRTEQQFESLAGRLPEVQSDVLSGLASGLPVEEVWAELADRIVSGVDTDDLVTAARRTPERIAFVSGPIELAAILAHPFDVWRTFLHPTQRDVAYRDSYSGPALVTGSAGTGKTVTGLHRAVFLAGRLPDDGTKVLLTTFTRALAEALDRQLYRLADNPAARDRIAVISVDKLAYDIVRRSGQKVGIADDEVLDQLWSAAAKAGPTYVDRAGRVTPFSAAFLRREWEQVILAQQLTTMAAYRDAPRRGRGEALRGAQREQVWAAIEGVVRELAKRRQRTHTQLADEAARIAAGAPSPYRHIVVDEGQDLHPAQWRLLRALVPPGPDDLFLLADPYQRIYDSHVSLGQLGIQVRGRTRRLTVNYRTTHEILDLSVKVLGGDAAVGLDDEGDSLRGYRSVTRGGVPTIVAHPDRHSESEALIEQVGTWLDQGVEPHAIGVAVRTGQLVATLSRTLAEAHIPVADDKCGTDGVKIATMHRMKGLEFQCLAVAGLDAEALPSPYALTPASEDPHAHRQDLQRERCLLFVALTRARDVLYLSHSGTPSSLLPEQR
>NZ_CP022961.1|WP_095565679.1|3945715_3947431_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MPVTGTPLTGTPSQPPGFSLVDEAWIPVLDAAGHRRDVSLPELFALAGDLRMIACELPTQTFAILRLALAILHRSTGGPAGEAAWRALWRDPRLPAGEIADYLGEFRDRFDLLHPQRPFYQVADLRAAKEDRYDLKRLIADVPNGMPFLTTRAGPGMASIPPAEAARWLVHCQAYDPSGIKTGALGDPRVKGGKGYPIGTGSVGALGGVYLEGATLRETLLLNLVPAAPRWQRSDERDLPVWEREPQTATEEPEATRGPYGPLSLYTWQSRRIRLFGTAGGITGAMISNGDRLDWQDRHLTEPMSVWGRSGPREREQKKTPIYLPRPHDHGRALWRGLQTLLPAPPQSGAEPAQRLSPMVVQWLARLTVDGVVGADFRVRPRAVSITYGTQMAVVDEVFSDALTMNVLLLVEDSGLRATAVDAAADADIAVVLLRRLAENLARAAGSRDDAVGDADRAGERGYALLDRAYRDWLARLGPGSDPAAERADWQRLVGRAIRRLGGELVAAAGPAAWIGRTRTDRNGRDVHYSSSQAEAWFHRGLTRALPMATGSEQQGPEQQGPEQQRQEEPV
>NZ_CP022961.1|WP_095565678.1|3945014_3945719_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MTVTETDRPKARGRRRRDLGEHVAGVVGALQARALANPPVPEAVGALARLRRGLGRAPGFDFGLERYLQVPEDLLGYRPADDTQATDSEHAVHDAVTLYALHQQSRRERMHVAGRGLGQALADLVRRSAGPDGVRRRFAALGTASTYPESIYHLRSLTTMLREQQIPLDYGLLADDLRLLRGLDGPAKVQAIWGREFFRSHPGADAGTPGAQASGAGTPDRNPRGTAATSTEEN
>NZ_CP022961.1|WP_095565677.1|3943842_3945012_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MNRTIIDLYALQTVPPSNLNRDDTGSPKTAIYGGVRRARVSSQAWKRAIRLAFADLLDPSQLGERTKRVGESLARRIRALEPELSDEEASALAANVFVTGGLAKLDKKKGELKDVESGYLLFLSHRQLDNLARAALEAERGGAPLDKARFKTLVDTEHSIDIAMFGRMVADMADINVDAACQVAHAISVHGVDNEFDYFTAVDDRKADAAETGAGMIGTIEFNSSTLYRYATVDVDALHETLGDPAATRAAVEAFLTAFARSMPTGKQNTFAHRTLPDAVLVRLRDTQPINLVGAFETPIRETQAAGRIELAAAALARHTAAVENAYGERPVASWVTQVGEQTAVLADLGKSVSFAELVAGVSEQVDVALGQSALGESGFGQPALGQPA
>NZ_CP022961.1|WP_095565676.1|3943144_3943846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSVLLLRLGGPLQSWGSSSRFARRGTEVAPSKSGVLGLLAAARGMRRTEPLTDLLGLEFGVRLDQPGQVLRDFQTARTLDGRQSAPLTYRFYLSDAVFLAAVGGAPDLLHGLAEALRRPKFPLYLGRRSCPPDGPVSLGVHDLTLDDALTQWPWLATERYRRRAARTERLEIIRDARPGEPVTETVPDTPVSFDPAHRQHTWRSVLRRHVDVSNELVERAGVTEHDPLSLLGG
>NZ_CP022961.1|WP_095567922.1|3960370_3961819_-|HAMP-domain-containing-histidine-kinase
MLAVTAVVLLVTGAGTAFALRGYLLARTDDQLDIAARFAQQRLGQLDGVPARGSLQAVIAPSDYLLELRRPDGSLTRMGSLQSVPGRPLLDRAPPAPPDGNLSPATNLADGRYRAVVGRTADGGSVLVALPLEPVRATIRQVLLTEIAVGLAMLLLLAVGGRLLVARGLRPLDRITATATAIADGELDRRVPPGPPERTEVGRLTLAVNGMLARIETALRARAASEDRMRRFVADASHELRTPLTSIRGYLQLLRQGIVGDPDRPEVLRRAEDEARRMGALVDGLLFLARLDAEPALRHEPFDLVAPLRDSVSDLLAVQPGRPARLELPPACRVRGDEDALRQVMANLLANVRVHTPPDVPVTVALRPADGYAEVEVGDRGPGVPAELAGRAFDRFTRGTGTGGGPGGAGGGPGGAGGGPGGAGAGGGGGFGAGGAGSGLGLAIVAEIVAAHGGTIGLDSSQRGTTVRFTLPLADPDPGAAG
>NZ_CP022961.1|WP_095565685.1|3961861_3962554_-|response-regulator-transcription-factor
MREAARVLVVDDQPNIVDMLATVLRFHGFQVSTAGSAAEAVRCAAEHRPDVVVLDVMLPDGDGFDVCRELRAGGHEIGIVFLTARDAPGDKINGLTYGGDDYVTKPFSVDELVARVRAVLRRIRPAAGQPQPGVLRFADVELDEEAIQVRRAGRLVELSPTEFKLLRYFMRHPNRVLSRAQILGEVWSYDFGGTSNVVDTYVGYLRRKLDQHGPTLIATRRGFGYTLTEG
>NZ_CP022961.1|WP_095565686.1|3962643_3964896_-|mycodextranase
MCVVRWHHGRQFSARSGSRPHTRGNATWPGRAAHPGTFHGWAHRTEVVPSPTERKNEASDGPRHRRGTAGPAPRGDHHRHRADHRRGRPGRRTGRRPTPERAGGPGATAATRTGAAGAAPAVTRAALDPALVAGRGARVGFVEQEAENAATDGEVIGPDRAAYTLPAEASGRMAVRLLPGQHVEFTLPAAANAITVRYSIPDAPTGGGSTAPLAVAANGRHLRTMTLTSRYGWLYNQYPFSNDPGAGLLHPDWWITECSCVPADTTPYPSIDTPFRPQHFYDEQRLLLGRTYRAGDRIRLTAPAGSSAAWTVIDLLDSELVAPPRIRLRAVNVLALGADPTGHRDAAPAIERAITLARLAKLPVYLPPGVYQVNRHIVVDDVTIEGAGSWYTLIKGHEVTLSEPAPDGSVHTGVGFYGRDAAEGGSHDVHLSGFAIEGDVRERIDTDQVNGIGGAFSDSTFDGLHIRHTKVGIWLDGPMRNVRITNTMIVDQIADGLNLHTGVTDSLVADTVIRNTGDDGLAMWSEGTGNARNTFAHNTVQSPVLANGIAIYGGTDNTVSDNLVADPVREGSALHVGSRFGAEPFTGTLSITDNTTVRAGTYELNWNIGLGAIWVYALDRDIDARIEVTGDAYLDSTYNAIMLVTEWSVKDLYSISDIHFRDVQVDGTGTSVLSARSAGAASFQNVDARNVGAVGVNNCGSFNFTPAGSEFGLTDLGGNDGGWLADWLLPNTITCDDRPPVVPPPPPAAW
>NZ_CP022961.1|WP_095565687.1|3965058_3967659_-|CHAT-domain-containing-protein
MELQRAAELHERAIAENARGRHALARRLLHQALRNDPDPQRRAHILISLAYHEAERRNLAAGLDLLRAAEAVPRLPRRLRGLAASQRGLLYMRAGQVDEAVEGFSAALRLLDGSAPHDVCRALLNRGILAMQHGGYAAAKADFARCAGLARRNGLDLLGAKAAHNLGYLALLSGDLPRALREMDAVAPSLTGQSPVYAAVYHIDRAQALLAAGLSREADEDLARAVELFRAARVRQDQAEAELARAQVAMLEQRWADARALAARARRRFTDRGAASWALLAAHVSVAARVEQGLRPGSAATEAAGLADQLQAAGLDEDARRARLTAALAALAGPHRGSDRARPDRGSDRAGPERGSDRAGPERGSDRVERAAELAGTALLLRRDDPIGTRLSARLARAALAEARGATAAANRERRAGLADLHRYQASFGSHDLRTAASGHGRRLAADGLGWALSTGRPAEVFQWAERARALSARLAPVLPPADEEAAALLEQLRHARVELRAQALAGRVDPSLRARCRRLEQRIRQRSWYASGAGETTEPAPLHRLCGQLGAADATFVAHLLSGDRLHALVATGRRQTVRDLGPAAAAIETHRQLRHDLDALAVSGLPEQIRATVRSASRAAVRRLDALLWEPVRPLLAGGPLLLAPSADLATVPWTMLPTLRGCPVAVVASVTAWLDRRDCGGLPASPRVALATGPGLARGADEIRLVAKTWSLNPPEEEASTADVRHAARVADVLHIAAHGVHEPDNPLFSHLGLADGPLFGHDLQALGRLPEHVVLSACELGLASTRPGDETLGMTASFLHGGAGSVVAGVARIADAAAYQVAPAHHAALSRGLSPAAALAAATAAVDADADPVPLVCFGAGW
>NZ_CP022961.1|WP_157756812.1|3967675_3968077_-|hypothetical-protein
MGALNPDGRTVALFSNSGPWVTAWQRGAALISTAPVTFQNGLNPLALTADPSGRQRATIDPDSFRSGFAVGTGTSFSAPVFAGCLAARLLSLADAGTLSLDDTSPAAVTRRSMAVDEVAAQDPWPFLSPEPAG
>NZ_CP022961.1|WP_095565689.1|3967986_3968487_-|S8-family-serine-peptidase
MDGVRDALAGHGTFICGLVHQTCPDAQILAIRIIRSDGRIDESDLIRALDQVYELARRHAAGEPNGRPVDIVSLSLGYYHELPEDLEYDSVLLEVLDRLAGLGIVVVASAGNDATTRLMFPAAFSTRSDPARAPLAGWGRSTRTAGPWRCSATAVRGSPPGSVAPL
>NZ_CP022961.1|WP_095565690.1|3968590_3969244_-|hypothetical-protein
MSAAYKPSDDERSLGDADPLLPPPGVLSRYGARVLDPASAVQLPGQRLRPTAYLADRLLVRSDAVGEVRELLDEAAKRLNLTVEFEQRDGKGYPVSGLLARLAPGERPAVVDAWQVLQEARAAARERGTTLRGVGLDHLMFGTTAVSGNPYHEANPYHEANPYHEANPYGAPATQYADPAFGGTRPVAVMLPRPRGAGSTGRRWWRSWTPVAASIRG
>NZ_CP022961.1|WP_095565691.1|3969278_3969740_-|hypothetical-protein
MNSDDRALLAELRSMWETADPVPADLATRALFLLELDDLDVELMSPSQELATAGARGAESISTITFASDQLTVMVTISHSGPQRHRLDGWLAPGVALRVDLRAGSEVRENVADANGRFVFTDVPSGFFQLVIHPTDHPAVRLTRPLVTPATQL
>NZ_CP022961.1|WP_095565692.1|3969736_3970345_-|sigma-70-family-RNA-polymerase-sigma-factor
MTRGMLEGATVDGLTDAWDTAARDFAAWRTGDRAGLDRLVRQMTPVLWHIARAYGLDPQTAEDAVQTTWLALVRNADSVRDPQAVWRWATTTVRREAWRLARAQRQEDAADPARLNEIGPVVPGPEEQVLSDDAARSLWQQVARLPERCRRLLRVIAFDDRPDYATLSNQLAIPIGSIGPTRGRCLDKLRRALAGDPRRRAR
>NZ_CP022961.1|WP_095565693.1|3970772_3972383_+|hypothetical-protein
MVGALGLTATDGSALAAETELPVYAVRAAGLDEGQAAELGKAFGIDVAREKDGSVRFADEKAFLAVPTVDGGQGREDEDGNPTTASLLDVAALRKIKPIDRETALRSASEALARAGLYPEGATATVGNTTFESVDGNGKSIVSAALDTTVAFSFALDKLPYEGPGAKVRVAFDGSGAVSQLSYSTRTLVADGTVPVLDLAAGRERCEKAMGGAVTVREPAYAYYAPALAERLDRVEPSFRCAGVNGDGTPAQVLFVPAAVDASLPELPPPPPPRDNSLRDNGLRANSLGATGLQASIQAYGVADVGSEGTGPCSGLPHTGSNLASFNNRMSSAGYPVEFSWLDQNAWEDDFKDPAYSGHDSNWTDHVDMTYWQGHGSPTGFSFSGCSSTDDTFLSNTEARWGNGDVEWMSLFTCLVLAHDSGGKAWWQRWGNAFDGLHQINSFDTVSYHSASHGGTFANYMVRTPFLWWNKPMSVRAAWAQASIDDQPSSVRWATMGPIGPGGLVNLNDYFWGKGSVGPDVPATQRTGWWYVSGLS

Crispr_ID: NZ_CP022961_23

• CRISPR_ID: NZ_CP022961_23
• CRISPR_location: 4498665-4498901
• CRISPR_type: Orphan
• Repeat_type: NA:?
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP022961_23

Consensus_repeat	Method
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CRISPRCasFinder
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC	CRT
GTTGCGATCCC------TCTAGGGGTGATGGGGCGAC	PILER-CR

spacers of NZ_CP022961_23

>23.1|4498696|39|NZ_CP022961|CRISPRCasFinder,CRT
CTGGGGAGACGGCCGCTGGCACCTGCCGTCCGGCCACGG
>23.2|4498766|37|NZ_CP022961|CRISPRCasFinder,CRT
ATCAACGGCGAAACGGTCTCCGAACTGTGGATCTTCC
>23.3|4498834|37|NZ_CP022961|CRISPRCasFinder,CRT
TCGGCCGGCTACCCCGAGATGGACGCGACCTCGATGC
>23.4|4498699|39|NZ_CP022961|PILER-CR
CTGGGGAGACGGCCGCTGGCACCTGCCGTCCGGCCACGG
>23.5|4498769|37|NZ_CP022961|PILER-CR
ATCAACGGCGAAACGGTCTCCGAACTGTGGATCTTCC
>23.6|4498837|37|NZ_CP022961|PILER-CR
TCGGCCGGCTACCCCGAGATGGACGCGACCTCGATGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_23

CRISPR arrays

The CRISPR arrays of NZ_CP022961_23

>merge|NZ_CP022961|23|4498665-4498901|CRISPRCasFinder,CRT,PILER-CR
ATCGCGATCCCTCTAGGGGTGATGGGGCGACCTGGGGAGACGGCCGCTGGCACCTGCCGTCCGGCCACGGGTTGCGATCCCTCTAGGGGTGATGGGGCGACATCAACGGCGAAACGGTCTCCGAACTGTGGATCTTCCGTTGCGATCCCTCTAGGGGTGATGGGGCGACTCGGCCGGCTACCCCGAGATGGACGCGACCTCGATGCGTTGCGATCCCTCTAGGGGTGATGGGGCGAC

>NZ_CP022961|23|24|4498665-4498901|CRISPRCasFinder
ATCGCGATCCCTCTAGGGGTGATGGGGCGAC	CTGGGGAGACGGCCGCTGGCACCTGCCGTCCGGCCACGG
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC	ATCAACGGCGAAACGGTCTCCGAACTGTGGATCTTCC
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC	TCGGCCGGCTACCCCGAGATGGACGCGACCTCGATGC
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC

>NZ_CP022961|23|7|4498665-4498901|CRT
ATCGCGATCCCTCTAGGGGTGATGGGGCGAC	CTGGGGAGACGGCCGCTGGCACCTGCCGTCCGGCCACGG
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC	ATCAACGGCGAAACGGTCTCCGAACTGTGGATCTTCC
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC	TCGGCCGGCTACCCCGAGATGGACGCGACCTCGATGC
GTTGCGATCCCTCTAGGGGTGATGGGGCGAC

>NZ_CP022961|23|7|4498668-4498901|PILER-CR
GCGATCCCTCTAGGGGTGATGGGGCGACCTG	GGGAGACGGCCGCTGGCACCTGCCGTCCGGCCACGGGTT
GCGATCCCTCTAGGGGTGATGGGGCGACATC	AACGGCGAAACGGTCTCCGAACTGTGGATCTTCCGTT
GCGATCCCTCTAGGGGTGATGGGGCGACTCG	GCCGGCTACCCCGAGATGGACGCGACCTCGATGCGTT
GCGATCCCTCTAGGGGTGATGGGGCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565992.1|4493668_4495030_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565986.1|4485284_4486193_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP022961.1|WP_095565996.1|4499255_4500005_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NZ_CP022961.1|WP_095565987.1|4486208_4487660_-|carbohydrate-ABC-transporter,-N-acetylglucosamine/diacetylchitobiose-binding-protein	unknown	unknown	gnl|CDD|274816
NZ_CP022961.1|WP_095565991.1|4492270_4493617_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl|CDD|179872
NZ_CP022961.1|WP_095566004.1|4508360_4509152_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566002.1|4505028_4507404_+|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl|CDD|236645
NZ_CP022961.1|WP_095567961.1|4490711_4492274_+|acyltransferase	unknown	unknown	gnl|CDD|376607
NZ_CP022961.1|WP_095565999.1|4501891_4503016_-|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl|CDD|223407
NZ_CP022961.1|WP_095565995.1|4499068_4499269_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP022961.1|WP_095566003.1|4507416_4508232_-|DUF3097-domain-containing-protein	unknown	unknown	gnl|CDD|378628
NZ_CP022961.1|WP_095565994.1|4496949_4497759_-|RNA-methyltransferase	unknown	unknown	gnl|CDD|223640
NZ_CP022961.1|WP_095565997.1|4500329_4500632_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566000.1|4503027_4503495_-|NfeD-family-protein	unknown	unknown	gnl|CDD|224501
NZ_CP022961.1|WP_095566001.1|4503578_4504895_+|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NZ_CP022961.1|WP_095565993.1|4495183_4496842_-|PucR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377939
NZ_CP022961.1|WP_095565985.1|4484343_4485285_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP022961.1|WP_095565998.1|4500797_4501628_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565988.1|4487862_4488816_-|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224651
NZ_CP022961.1|WP_095565989.1|4489063_4490089_+|ATPase	unknown	unknown	gnl|CDD|225518

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565986.1|4485284_4486193_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.25895e-66
NZ_CP022961.1|WP_095566000.1|4503027_4503495_-|NfeD-family-protein	gnl|CDD|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.85284e-27
NZ_CP022961.1|WP_095565996.1|4499255_4500005_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	0.000120856
NZ_CP022961.1|WP_095565987.1|4486208_4487660_-|carbohydrate-ABC-transporter,-N-acetylglucosamine/diacetylchitobiose-binding-protein	gnl|CDD|274816	TIGR03851, chitin_NgcE, carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein. Members of this protein family are the substrate-binding protein, a lipid-anchored protein of Gram-positive bacteria in all examples found so far, that include NgcE of the chitin-degrader, Streptomyces olivaceoviridis, and close homologs from other species likely to share the same function. NgcE binds both N-acetylglucosamine and the chitin dimer, N,N'-diacetylchitobiose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP022961.1|WP_095565991.1|4492270_4493617_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl|CDD|179872	PRK04690, murD, UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.	1.03818e-178
NZ_CP022961.1|WP_095566002.1|4505028_4507404_+|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	7.18378e-100
NZ_CP022961.1|WP_095567961.1|4490711_4492274_+|acyltransferase	gnl|CDD|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	5.07236e-18
NZ_CP022961.1|WP_095565999.1|4501891_4503016_-|SPFH/Band-7/PHB-domain-protein	gnl|CDD|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	3.33398e-64
NZ_CP022961.1|WP_095565995.1|4499068_4499269_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.13827e-21
NZ_CP022961.1|WP_095566003.1|4507416_4508232_-|DUF3097-domain-containing-protein	gnl|CDD|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	8.3047e-153
NZ_CP022961.1|WP_095565994.1|4496949_4497759_-|RNA-methyltransferase	gnl|CDD|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.30102e-55
NZ_CP022961.1|WP_095566001.1|4503578_4504895_+|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.75896e-53
NZ_CP022961.1|WP_095565993.1|4495183_4496842_-|PucR-family-transcriptional-regulator	gnl|CDD|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	6.41481e-39
NZ_CP022961.1|WP_095565985.1|4484343_4485285_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.38113e-82
NZ_CP022961.1|WP_095565988.1|4487862_4488816_-|MurR/RpiR-family-transcriptional-regulator	gnl|CDD|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.46558e-67
NZ_CP022961.1|WP_095565989.1|4489063_4490089_+|ATPase	gnl|CDD|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	9.52951e-24

Protein sequences

>NZ_CP022961.1|WP_095565994.1|4496949_4497759_-|RNA-methyltransferase
MAVHEITDADDQRIADYRALTDVELRTRWEPPHGLFIAEGELVLRRALRAGYPPRSFLLDAKRLDQLGDLDTGDAPVYAARPEVLERATGFHVHRGILASFHRRPLPEPAALLDTARRVLVLEDVNNHTNLGAIFRGAAALGIDAVLLSPSCADPLYRRSVRVSMGEVFAVPYARLEPWPDGLGAVRAAGFTVLAMTPAPDAVPIQRLTAAQRDRTALLLGAEGPGLTAGAQRASDVRVVIPMRRGVDSLNVAAAAAVACWELGRDDPA
>NZ_CP022961.1|WP_095565993.1|4495183_4496842_-|PucR-family-transcriptional-regulator
MTAVFPTVREVLDLGPLRRGAPRVLAGESSLGRRVRWVHVAEVPDIASLLDGGELVLTTGIGLPAEDAGLRAFVDDLAEVGASGLVVELGRRYPESVPRAMVLAAGRRGLPLIELRRATPFVPITEAVHALIVDAQLTELRATEEIHQRFTELSVEGAEPAEVVRQAAELAGCPVVLENPARQVLAYDPAGEDPGSVLDGWERHSRRVRPTGRTGYDPDAGWLATTVGARGQDWGRLLLRWPGTDMPPSRLTILLERAASTLALGRLIRRDAEGLERQIHRNLLTALLDHARPVDEVALRARALGVALDRRRLVGVMVRHRGDPAGEPGAEAAQARLHDLAEAVGRAIRDAGLTGLASAVDEQAVGALLALAPGQADDAALSAFAAALERVRLTGSGWPGGEPSVVVAAGSTVPTLREARRTLVEARQVADAARRGRRDLPVFRLSQVGIAGLLHLLRDEPRVQTFVERELGALLAYDAEHPREHLLDTLRAYLDHGRNKSAAAAAAHLSRPAFYERLIRIGRILDADLDSVPACLSLHVALLALDAIHDDA
>NZ_CP022961.1|WP_095565992.1|4493668_4495030_+|hypothetical-protein
MPTEQLRQMDAFSFPAYSLDPATGAVALEYALRGPGGELRFTERITLPAPARPPSPAAAAALDRVVQLLHLVAGVSYYKTAAPRRLVLPGPLGPAATGYVTAVYTQGLAEYAYRNDLPYVLELVPEVEAGAETGSGGGAPELDSSGGRPLSAVGGGKDSIVTLEALRRAGLDPVPFSVNPNPVIVSVNEASGLTALAARRAIDPELFALNKAGARNGHIPVTAINSLIAVATAVLHGLGPVVMSNERSASDPNLIWHGHEINHQWSKGLAAEGLLRAALTEHAGLVEPYFSLLRPLSELHIARLFAQFDAYDGVVTSCNAAFRLHDPSARWCGDCPKCRFVFLALAPFMPRDRLVRIFGKDMLADPGQVPGYLELLGIDAHKPFECVGEVEESTVALSLLAEQEQWRTAPVVQALVAAVPAEGWAAAADSDVFSPAGTSFAPASYAKALTALA
>NZ_CP022961.1|WP_095565991.1|4492270_4493617_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MRLSDLRGRAVVVWGTGREGRAAVKAVAAQEPASLIVVEDSESFLSTSWEGPLAQAAPLVSGPEAFDRLAAADVVIRSPGVPQTHPWVIELRAKGVPITGGTALWMAQHADRTVGVTGSKGKSTTSSLISHLLTAMGRPNAYGGNIGVPLLDLPESELYVLELSSYQCSDLTDSPRVAVVTSLFPEHLDAHGGEQEYYRDKLNLLAHGPETIVLNGTDERLAAQVGDRPALRVGRPDSVHVAPGPVDEPYLYVRTVPLFPRSVFPLVGRHNEGNLCLALAVLAALGVDLEARREELEEAVGTFAGLPHRLAEIADPSGLTFVDDTLATSPYSTVHAIDAYVGRPLTVIVGGTDRGLDYAPLRDCLAAHPATVIGIPDSGARIVEALHGLAGVRTAVVDDLAAAVRAARELTPAGGVVLLSPGAPSYGRYRNFEHRSEAFAAAIRDTAP
>NZ_CP022961.1|WP_095567961.1|4490711_4492274_+|acyltransferase
MHRLRWLARNTPAGRERYVDLLRAVAIVAVVSGHWLMTVIGHDASGQLAGHNALQELTNERVATWLFQVLPIFFLVGGYANAASLTSRTARGGGAGDWLVERSGRLLRPTSTFLAVLVVVAVVARWIGADPREIRTVIWFVTVPLWFLAPYLLVVVLTPVMFALHRRAGAAVPAVLVGLVALGDIGRLAGPAWLSFGNYLFGWLLPHQIGFAWRTGGLRIRPRAAAALAVGGLVALILLTEVGPYPTSMINLSGQRIQNMSPPSLALLSLAAAQLGVILLLRGPAERMLHRTRPWMLVVAINAVVLTIFLWHLTALLLLAGALEGLGLLPTPAAGSAGWWLLRPPWLVLGAIALAPLVAVFGPVEARAGRRRGARSSAGAGVPLPLPGPLNRTGPLRRTRPLNGIRPLNRIRPRAPAAARRLRAGLAAAGFLAVIVGLLANSRFPRAEPTPLGIPVWALAAYLGGAAALRLLRVTDPAGNATHSSAAHSSAADRPGAGSPATDNSGTDNSGTNRPAAGGS
>NZ_CP022961.1|WP_095565989.1|4489063_4490089_+|ATPase
MAQELVLGMDIGGSTTRAEVVTTDGERRGTGRAGGGNPTSHGAPAAAAELGSALRHALRDVDPGTVRAGLIGLAGVGRLLADAQGRAAFDRAWRDAGLRCGYELHGDALVAYASGTADPDGTVLIAGTGAIAAQFRDLRQGHTADGHGWLLGDAGSGFWLGREAVRHTLAALDAETEPSALGRAVLTELLGDAVVETPPRRTVSRLVQAVTRRSPVDLARLAPLVLGHAEGAAEVGEGAAPIVTVDEGAARIVAAAAARLTATVARIRPAGQVHPVVLAGGLLGVDNPLTRAVRAALAERWPAAPLLPARDGALAAAWLAARGLDPDRDRAAALHARLLGG
>NZ_CP022961.1|WP_095565988.1|4487862_4488816_-|MurR/RpiR-family-transcriptional-regulator
MVEPDAAATVVDGATVDRRGTGNRTVADSVLAHVRSRLPEFTGALRRVADEVLADPDRAARATIVELAERSGTSPATVTRFCRALGFEGYAGLRLGIAAETGRARSAGWAVDIGREIQPGDPLDRVLGQIMAADTRAMHDTAALLDLAEVGRAADAIARAPRVNIFGASGSALVGEEMRSCLHRIGIPAWAWRDVHDGLAAASLLGTGDVALGVSHSGQTRETIELLAEAGSHGATTVALTSFPSAALAELADIVLLTATQATTFRPDALSARHPQLVVLDLLYIAVAQRTHSRAHAAFQRTAQAVDGHKAARDGSA
>NZ_CP022961.1|WP_095565987.1|4486208_4487660_-|carbohydrate-ABC-transporter,-N-acetylglucosamine/diacetylchitobiose-binding-protein
MSVTPDRPSDLTRRTLLGRTAAAGLLVTPAAGLLSACATSGSDDTGKKDGAEGTKSDQNPLGVKEDAALEVIIFNGGYGEKYATDVHEPLYKKEFPKAEIKHQSTQAISTVLQPRFAAGNPPEFVNNSGEKLMDFGALVKDGQLQDLTELWDAPSVDDPSKKVRDTVVPGTVEQGMYDTGDGAKPYVLYYVSTVYGLWYSGKLFQSNGWQPAKTWDEFMGLLDKIKGKGITPYGYAGANAAYYQWNVILTHAAKIGGADVLKNIDNLTPGAWTADPVLKAATAWAEVGAKYLDKSFEGLKHTDVQLQQDQYKVGFYPSGDWLENEQKQNTPPDFQYQLTTMPDLTSADAMPFGALRAAAGEGYFVSARSNNPRGGMEYMRQMLSTAGAKGFTETVKAATVVPAGSEGYAFPPGVASSQAALKAAGANVVNLMFDNWYKELDTECRTATNELMFGRVKAEQFCERMQKRADALTKDDSVAKFQR
>NZ_CP022961.1|WP_095565986.1|4485284_4486193_-|sugar-ABC-transporter-permease
MRHGKYPFVVGFLAAPVTLYAVFVIAPYAQAFQISMTDWRGFSAPNYIGFENFRRLFHDHRFWQAIEHHGILLLALPLITIAIALFFAFLLNVGGRSRGGQRRGVWGSNFYRVVFFFPQVLAVAIVAVLFQTVYRPNSSGLINGVLMKLGLDPVLFLVRPSLALWSIIAVLVWQAVGFYVVLFSAGMSAIPPDIYEAAEMDGATRVTLFFRVTLPLLWDTLQVAWVYLGIAAFDAFAIVSVLSVDNGGPDGATTVLALEIYRNAFVYSKYGYASAMGVALFFLTLTFAALTLRLSRRESVEY
>NZ_CP022961.1|WP_095565985.1|4484343_4485285_-|carbohydrate-ABC-transporter-permease
MNPHTTTQVTAPAPSAGAAGGLAAGALPDGRRRRRGRSEVSVLTGLGQAALIIWAILVIAPILWTFLASFKNTTEIFSSPWTMPDHLRWENWSRAWTKAHVGRYFLNSVLVVSLSTFGTMLLGSMAAYVLARYRFWGNRFIYYMFVSGLAFPVFLALVPLFFVVRNLHLLDSYTGLVLVYIAYSLPFTIFFLAAFFKTLPSSVAEAGLIDGASHTRLFFQVMLPMAKPGLVSVAIFNVIGQWAQYQLPLVLLSNAKDKWVLTQGIADISVNAGYEADWSGLFAALTIAILPMIVVYAIFQRQIQSGLTSGAVK
>NZ_CP022961.1|WP_095565995.1|4499068_4499269_-|DUF397-domain-containing-protein
MDLGNAIWKKSTRSGTSGGDCVEVAGNLPGIVGVRDSKDPAGPALVFRPGAWQGFVDLAKRIGPVG
>NZ_CP022961.1|WP_095565996.1|4499255_4500005_-|helix-turn-helix-domain-containing-protein
MRIAAELNQEEFGRRINYSSSTVSAIETGARPLDRMFLRRADDILGTDGLLASLLKMADRDREPSWFRPWLEAERSASQLRYFNPTLVPGLLQTANYARAVLRFDPTRPEEEVERQVAARLERQEILGRDQPPLVVAVIDESALRRRDAIMAEQLAHLLRLAELPHLQLHVIPADAGMYVGLSGPLALARSAEGGWVGHLENQLAALVVDAEDGIATLLARWEGVRGVALPHALSIALVKEVQSQHGPR
>NZ_CP022961.1|WP_095565997.1|4500329_4500632_+|hypothetical-protein
MLRRRNGTTVHRAYHVPLRPTWLCRICAAPWPCGSAKLALLAGHGRDQISLMMTLAHYLHEALYDLAEVCGPHAPAPQRLHARFLGWVTRPHRQPRGRAP
>NZ_CP022961.1|WP_095565998.1|4500797_4501628_-|hypothetical-protein
MDEQPERRTGAEDPRAVLAERFDPPPGLLPPRPTRVPDDPRRMSPLQASLVRPVRVVGRVGLNLLPFFDEPDPVRPASNTSWVWSLRRFARSAVWLLPGYAVLLAISTAGADGLRRSATFSAGAGLRVLGLALATWVGLLALTALTGLLATARTRGTATAGLLLAMFGALLLPLAPLGGPGFVRVLALLGGGVLTLGWVLAGLAVARSGVFGAFDGTLLVIAAPMIGLGGLLLGILQTVGALLVLAAGIGIAAKTGRLLPKPGSTLAPEPSGGAPA
>NZ_CP022961.1|WP_095565999.1|4501891_4503016_-|SPFH/Band-7/PHB-domain-protein
MGTAIAVLVGAVALIVVITLIRAVRIVPQQRMDVVERLGRYKRTLSPGLNLLVPFIDAVRTKVDMREQVVSFPPQPVITSDNLVVSIDTVLYFKVVDPVRATYEISNFLQAIEQLTVTTLRNVIGSLDLERALTSREEINRHLSVVLDETTGRWGVKVTRVEIKAIEPPPSIRDSMEKQMRAERDRRAAILNAEGLKQSQILTAEGEKQAAVLRADGDRQSRILQAEGQAKAIRTVFDAIHTANPSQKVLAYQYLQALPQIAAGQANKVWIVPAELTKALEGLGGALGGLSGTAGDTPSAEVDSGAVEREAREAAAAAAAAAAEVNHEVRAAEAQVSSGDKTQQLTAGQPVAPGSLVGESQPEQEPDSERTQRL
>NZ_CP022961.1|WP_095566000.1|4503027_4503495_-|NfeD-family-protein
MEPLLWIVLGAALAIAELFTTTLFLIMFSVGAFAAAGAAALGAPVSVQALVFAVVSVLTVLLGRPGLQRRRLAQEDGEGRPFGAAAIEGQRALVLERVDTDSGQVKIDGELWSARSFDATQVFEPGERVQVIEVRGVTALVWRDDFSASGELPES
>NZ_CP022961.1|WP_095566001.1|4503578_4504895_+|serine-hydrolase
MTLLPETTHRIDTIVTEAQAAGAIPSLIVGVVRDGRLAHVSTAGSQPAADPDMQYRIGSISKTMTAVLLLSQRDAGRLALDDPLERHLPGTPVGTVTLRQLLGHASGLQREPDGSWWERTEGADLATLVAGLTAGKLTHPPQTVYHYSNLAYGLLGGVLERLTGQPWWELVRTRLLDPLGMARTTYQATEPFARGYVVHPWNGTMREEPRTDTGAMAAAGQLWSTPADLARWAAFLADPDPAVLRPETLAEMCLPVIMSEPDSWGHGHGLGIELTRSGDRVYVGHGGSMPGYLAALGVHRPSRTGLVAFANCYNPRTLHLGANAVELLDLVLDADPPAPAQPWSAAGDPPRDAADLLGRWWWMGKEFTASWDADNDELVFAPQGRLPWRLTRAGTDRWRCHSGMNNGEFLTVRRDPAGRPDTVDIATFVFSRDPDRVG
>NZ_CP022961.1|WP_095566002.1|4505028_4507404_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MSGIAGPAALASRFGRISLWLALGLGTAVLLTETAWLVLRLPDAATASDAAATLVAGIAAGCCLAVSRRHPANLRRFWLLMALTMALAATGRIIWTVTRLTTGGGLPNNLAVALVFVAGIVSGTAALLSCVSAPPTAAGRLRTLLDGVIVGLALVPVSWVVVLRDVAAAPLAETPRTLGLFYPMFDVMQLTILVAISGPLRPVWRPLSTIGAGLAIRAVADTVYVAQIARGTYEAGHPIDVCWPLSYLLVAVATRYPAPGGIDPAGGAETEPDADPPIVPWWRLALPYLPVCGAAVAMVLARQPGQPLPPPVFLAGTGLLVALAIRQSLTAYETTNLADRLRRLAYVDQLTGLPNRLQFTRRLRRCIRERRPVAVLLLDLDGFKQVNDRFGHASGDTLLTNVASRMRAVVGGSGMIARIGGDEFAVLLETGDDPGPARPAGPDRETDPGPGRTAERDPDRLARRLLAALGPGGPKADWLLHSSASIGIAEYGPQHQGHTDLLRDADIAMYAAKAAGKSAYRTCTPRLREAAVGRAELIADLRRAVLEAEQLELEFQPIVELGTGTVRGAEALVRWRHPRHGLLAPDRFLPLAEETGLILTVDRWVIRAACRAAAGWQLLSPGTTVAVNVAAGHLRRADLTETVAEATAAAGLPPESLTLELTETALIEGTEAVLDRLGQLRDLGVRIALDDFGTGYSALNYLHRIPATELKIDRSFVRRLDGSDQRAYATVEMIRRLAGAFGLGVVAEGVETDAQHAAVAEIGCPHGQGYRYGRPRPLPDLHRLLVAQRPG
>NZ_CP022961.1|WP_095566003.1|4507416_4508232_-|DUF3097-domain-containing-protein
MGRRYGEDVLAGDWRRRRVTPEVDAEPDLVVEDADSGFCGAVVGFEQGAVVLEDRHGRRRNFPLLPAAFLLDGEAVTLRRPAARPAPAPRRRTASGSVAVAGVRARVAQASRIWVEGVHDAALVERIWGDDLRIEGIVVEPLDGIDALADRVREFEPGPRRRLGVLVDHLVSGSKESRIVAAVTSPDVLVTGHPYVDVWQAVRPRALGIPAWPVVPPGRPWKEGVCAALGVAEPAAMWRHILSRVDSFADVETPLINAMERLIDFVTVPPG
>NZ_CP022961.1|WP_095566004.1|4508360_4509152_+|hypothetical-protein
MSAPTDAVTLAPRRSSRFVAWVRAWRTGLVPFDEVADEIADGEEHLVADAPGTWTDVPLTEALPVLSRTPPDRVRLVLPVPGDPRGLPGPGPFAGAALLAGEAVVAGDLGVIPEVRSHTSGSGMTFETVLWRVYPLPAGAAAAARHEPGAAEAEAELAAALAEATAALTRLDVAAWRPELAGALAALRRPDSCKDLPPGFDPRARRLFARASVLDRVLALAEHAAPGGAVNGYEAQQRDAALRPLTAACRRALVAACNAPLRP

Crispr_ID: NZ_CP022961_22

• CRISPR_ID: NZ_CP022961_22
• CRISPR_location: 4497861-4498295
• CRISPR_type: Orphan
• Repeat_type: NA:?
• Spacer_info: 6 spacers

Consensus repeat of NZ_CP022961_22

Consensus_repeat	Method
GTTGCGATCCC------TCCAGGGGTGATGGGGCGAC	PILER-CR
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CRISPRCasFinder
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CRT

spacers of NZ_CP022961_22

>22.1|4497892|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CCGTCGTCCTGACGGACATGGGCCAGTCGCTGAA
>22.2|4497957|35|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
AACCCCCGCGCGGGCTCGGGCGGGCCGCTGTTTTT
>22.3|4498023|40|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CTGCGGCGGTTGACACCAAGATGGCGGCCCTCTCCGTGTA
>22.4|4498094|36|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
GGCTCGTCACTGGGGCCGGACCCAGGCCCAGGCAAT
>22.5|4498161|36|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT
CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT
>22.6|4498228|36|NZ_CP022961|CRISPRCasFinder,CRT
CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT

CRISPR arrays and Neighbor proteins around NZ_CP022961_22

CRISPR arrays

The CRISPR arrays of NZ_CP022961_22

>merge|NZ_CP022961|22|4497861-4498295|PILER-CR,CRISPRCasFinder,CRT
GTTGCGATCCCTCCAGGGGTGATGGGGCGACCCGTCGTCCTGACGGACATGGGCCAGTCGCTGAAGTTGCGATCCCTCCAGGGGTGATGGGGCGACAACCCCCGCGCGGGCTCGGGCGGGCCGCTGTTTTTGTTGCGATCCCTCCAGGGGTGATGGGGCGACCTGCGGCGGTTGACACCAAGATGGCGGCCCTCTCCGTGTAGTTGCGATCCCTCCAGGGGTGATGGGGCGACGGCTCGTCACTGGGGCCGGACCCAGGCCCAGGCAATGTTGCGATCCCTCCAGGGGTGATGGGGCGACCGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCTGTTGCGATCCCTCCAGGGGTGATGGGGCGACCGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCTGTTGCGATCCCTCCAGGGGTGATGGGGCGACC

>NZ_CP022961|22|6|4497861-4498227|PILER-CR
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CCGTCGTCCTGACGGACATGGGCCAGTCGCTGAA
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	AACCCCCGCGCGGGCTCGGGCGGGCCGCTGTTTTT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CTGCGGCGGTTGACACCAAGATGGCGGCCCTCTCCGTGTA
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	GGCTCGTCACTGGGGCCGGACCCAGGCCCAGGCAAT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC

>NZ_CP022961|22|23|4497861-4498295|CRISPRCasFinder
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CCGTCGTCCTGACGGACATGGGCCAGTCGCTGAA
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	AACCCCCGCGCGGGCTCGGGCGGGCCGCTGTTTTT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CTGCGGCGGTTGACACCAAGATGGCGGCCCTCTCCGTGTA
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	GGCTCGTCACTGGGGCCGGACCCAGGCCCAGGCAAT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT
GTTGCGATCCCTCCAGGGGTGATGGGGCGACC

>NZ_CP022961|22|6|4497861-4498294|CRT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CCGTCGTCCTGACGGACATGGGCCAGTCGCTGAA
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	AACCCCCGCGCGGGCTCGGGCGGGCCGCTGTTTTT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CTGCGGCGGTTGACACCAAGATGGCGGCCCTCTCCGTGTA
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	GGCTCGTCACTGGGGCCGGACCCAGGCCCAGGCAAT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC	CGAACCGGGCCAGCTCCCCAGGATGCTTGAGATCCT
GTTGCGATCCCTCCAGGGGTGATGGGGCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095565992.1|4493668_4495030_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565986.1|4485284_4486193_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP022961.1|WP_095565996.1|4499255_4500005_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NZ_CP022961.1|WP_095565987.1|4486208_4487660_-|carbohydrate-ABC-transporter,-N-acetylglucosamine/diacetylchitobiose-binding-protein	unknown	unknown	gnl|CDD|274816
NZ_CP022961.1|WP_095565991.1|4492270_4493617_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl|CDD|179872
NZ_CP022961.1|WP_095566004.1|4508360_4509152_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566002.1|4505028_4507404_+|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl|CDD|236645
NZ_CP022961.1|WP_095567961.1|4490711_4492274_+|acyltransferase	unknown	unknown	gnl|CDD|376607
NZ_CP022961.1|WP_095565999.1|4501891_4503016_-|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl|CDD|223407
NZ_CP022961.1|WP_095565995.1|4499068_4499269_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP022961.1|WP_095566003.1|4507416_4508232_-|DUF3097-domain-containing-protein	unknown	unknown	gnl|CDD|378628
NZ_CP022961.1|WP_095565994.1|4496949_4497759_-|RNA-methyltransferase	unknown	unknown	gnl|CDD|223640
NZ_CP022961.1|WP_095565997.1|4500329_4500632_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566000.1|4503027_4503495_-|NfeD-family-protein	unknown	unknown	gnl|CDD|224501
NZ_CP022961.1|WP_095566001.1|4503578_4504895_+|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NZ_CP022961.1|WP_095565993.1|4495183_4496842_-|PucR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377939
NZ_CP022961.1|WP_095565985.1|4484343_4485285_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP022961.1|WP_095565998.1|4500797_4501628_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095565988.1|4487862_4488816_-|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224651
NZ_CP022961.1|WP_095565989.1|4489063_4490089_+|ATPase	unknown	unknown	gnl|CDD|225518

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095565986.1|4485284_4486193_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.25895e-66
NZ_CP022961.1|WP_095566000.1|4503027_4503495_-|NfeD-family-protein	gnl|CDD|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.85284e-27
NZ_CP022961.1|WP_095565996.1|4499255_4500005_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	0.000120856
NZ_CP022961.1|WP_095565987.1|4486208_4487660_-|carbohydrate-ABC-transporter,-N-acetylglucosamine/diacetylchitobiose-binding-protein	gnl|CDD|274816	TIGR03851, chitin_NgcE, carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein. Members of this protein family are the substrate-binding protein, a lipid-anchored protein of Gram-positive bacteria in all examples found so far, that include NgcE of the chitin-degrader, Streptomyces olivaceoviridis, and close homologs from other species likely to share the same function. NgcE binds both N-acetylglucosamine and the chitin dimer, N,N'-diacetylchitobiose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP022961.1|WP_095565991.1|4492270_4493617_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl|CDD|179872	PRK04690, murD, UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.	1.03818e-178
NZ_CP022961.1|WP_095566002.1|4505028_4507404_+|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	7.18378e-100
NZ_CP022961.1|WP_095567961.1|4490711_4492274_+|acyltransferase	gnl|CDD|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	5.07236e-18
NZ_CP022961.1|WP_095565999.1|4501891_4503016_-|SPFH/Band-7/PHB-domain-protein	gnl|CDD|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	3.33398e-64
NZ_CP022961.1|WP_095565995.1|4499068_4499269_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.13827e-21
NZ_CP022961.1|WP_095566003.1|4507416_4508232_-|DUF3097-domain-containing-protein	gnl|CDD|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	8.3047e-153
NZ_CP022961.1|WP_095565994.1|4496949_4497759_-|RNA-methyltransferase	gnl|CDD|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.30102e-55
NZ_CP022961.1|WP_095566001.1|4503578_4504895_+|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.75896e-53
NZ_CP022961.1|WP_095565993.1|4495183_4496842_-|PucR-family-transcriptional-regulator	gnl|CDD|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	6.41481e-39
NZ_CP022961.1|WP_095565985.1|4484343_4485285_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.38113e-82
NZ_CP022961.1|WP_095565988.1|4487862_4488816_-|MurR/RpiR-family-transcriptional-regulator	gnl|CDD|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.46558e-67
NZ_CP022961.1|WP_095565989.1|4489063_4490089_+|ATPase	gnl|CDD|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	9.52951e-24

Protein sequences

>NZ_CP022961.1|WP_095565994.1|4496949_4497759_-|RNA-methyltransferase
MAVHEITDADDQRIADYRALTDVELRTRWEPPHGLFIAEGELVLRRALRAGYPPRSFLLDAKRLDQLGDLDTGDAPVYAARPEVLERATGFHVHRGILASFHRRPLPEPAALLDTARRVLVLEDVNNHTNLGAIFRGAAALGIDAVLLSPSCADPLYRRSVRVSMGEVFAVPYARLEPWPDGLGAVRAAGFTVLAMTPAPDAVPIQRLTAAQRDRTALLLGAEGPGLTAGAQRASDVRVVIPMRRGVDSLNVAAAAAVACWELGRDDPA
>NZ_CP022961.1|WP_095565993.1|4495183_4496842_-|PucR-family-transcriptional-regulator
MTAVFPTVREVLDLGPLRRGAPRVLAGESSLGRRVRWVHVAEVPDIASLLDGGELVLTTGIGLPAEDAGLRAFVDDLAEVGASGLVVELGRRYPESVPRAMVLAAGRRGLPLIELRRATPFVPITEAVHALIVDAQLTELRATEEIHQRFTELSVEGAEPAEVVRQAAELAGCPVVLENPARQVLAYDPAGEDPGSVLDGWERHSRRVRPTGRTGYDPDAGWLATTVGARGQDWGRLLLRWPGTDMPPSRLTILLERAASTLALGRLIRRDAEGLERQIHRNLLTALLDHARPVDEVALRARALGVALDRRRLVGVMVRHRGDPAGEPGAEAAQARLHDLAEAVGRAIRDAGLTGLASAVDEQAVGALLALAPGQADDAALSAFAAALERVRLTGSGWPGGEPSVVVAAGSTVPTLREARRTLVEARQVADAARRGRRDLPVFRLSQVGIAGLLHLLRDEPRVQTFVERELGALLAYDAEHPREHLLDTLRAYLDHGRNKSAAAAAAHLSRPAFYERLIRIGRILDADLDSVPACLSLHVALLALDAIHDDA
>NZ_CP022961.1|WP_095565992.1|4493668_4495030_+|hypothetical-protein
MPTEQLRQMDAFSFPAYSLDPATGAVALEYALRGPGGELRFTERITLPAPARPPSPAAAAALDRVVQLLHLVAGVSYYKTAAPRRLVLPGPLGPAATGYVTAVYTQGLAEYAYRNDLPYVLELVPEVEAGAETGSGGGAPELDSSGGRPLSAVGGGKDSIVTLEALRRAGLDPVPFSVNPNPVIVSVNEASGLTALAARRAIDPELFALNKAGARNGHIPVTAINSLIAVATAVLHGLGPVVMSNERSASDPNLIWHGHEINHQWSKGLAAEGLLRAALTEHAGLVEPYFSLLRPLSELHIARLFAQFDAYDGVVTSCNAAFRLHDPSARWCGDCPKCRFVFLALAPFMPRDRLVRIFGKDMLADPGQVPGYLELLGIDAHKPFECVGEVEESTVALSLLAEQEQWRTAPVVQALVAAVPAEGWAAAADSDVFSPAGTSFAPASYAKALTALA
>NZ_CP022961.1|WP_095565991.1|4492270_4493617_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MRLSDLRGRAVVVWGTGREGRAAVKAVAAQEPASLIVVEDSESFLSTSWEGPLAQAAPLVSGPEAFDRLAAADVVIRSPGVPQTHPWVIELRAKGVPITGGTALWMAQHADRTVGVTGSKGKSTTSSLISHLLTAMGRPNAYGGNIGVPLLDLPESELYVLELSSYQCSDLTDSPRVAVVTSLFPEHLDAHGGEQEYYRDKLNLLAHGPETIVLNGTDERLAAQVGDRPALRVGRPDSVHVAPGPVDEPYLYVRTVPLFPRSVFPLVGRHNEGNLCLALAVLAALGVDLEARREELEEAVGTFAGLPHRLAEIADPSGLTFVDDTLATSPYSTVHAIDAYVGRPLTVIVGGTDRGLDYAPLRDCLAAHPATVIGIPDSGARIVEALHGLAGVRTAVVDDLAAAVRAARELTPAGGVVLLSPGAPSYGRYRNFEHRSEAFAAAIRDTAP
>NZ_CP022961.1|WP_095567961.1|4490711_4492274_+|acyltransferase
MHRLRWLARNTPAGRERYVDLLRAVAIVAVVSGHWLMTVIGHDASGQLAGHNALQELTNERVATWLFQVLPIFFLVGGYANAASLTSRTARGGGAGDWLVERSGRLLRPTSTFLAVLVVVAVVARWIGADPREIRTVIWFVTVPLWFLAPYLLVVVLTPVMFALHRRAGAAVPAVLVGLVALGDIGRLAGPAWLSFGNYLFGWLLPHQIGFAWRTGGLRIRPRAAAALAVGGLVALILLTEVGPYPTSMINLSGQRIQNMSPPSLALLSLAAAQLGVILLLRGPAERMLHRTRPWMLVVAINAVVLTIFLWHLTALLLLAGALEGLGLLPTPAAGSAGWWLLRPPWLVLGAIALAPLVAVFGPVEARAGRRRGARSSAGAGVPLPLPGPLNRTGPLRRTRPLNGIRPLNRIRPRAPAAARRLRAGLAAAGFLAVIVGLLANSRFPRAEPTPLGIPVWALAAYLGGAAALRLLRVTDPAGNATHSSAAHSSAADRPGAGSPATDNSGTDNSGTNRPAAGGS
>NZ_CP022961.1|WP_095565989.1|4489063_4490089_+|ATPase
MAQELVLGMDIGGSTTRAEVVTTDGERRGTGRAGGGNPTSHGAPAAAAELGSALRHALRDVDPGTVRAGLIGLAGVGRLLADAQGRAAFDRAWRDAGLRCGYELHGDALVAYASGTADPDGTVLIAGTGAIAAQFRDLRQGHTADGHGWLLGDAGSGFWLGREAVRHTLAALDAETEPSALGRAVLTELLGDAVVETPPRRTVSRLVQAVTRRSPVDLARLAPLVLGHAEGAAEVGEGAAPIVTVDEGAARIVAAAAARLTATVARIRPAGQVHPVVLAGGLLGVDNPLTRAVRAALAERWPAAPLLPARDGALAAAWLAARGLDPDRDRAAALHARLLGG
>NZ_CP022961.1|WP_095565988.1|4487862_4488816_-|MurR/RpiR-family-transcriptional-regulator
MVEPDAAATVVDGATVDRRGTGNRTVADSVLAHVRSRLPEFTGALRRVADEVLADPDRAARATIVELAERSGTSPATVTRFCRALGFEGYAGLRLGIAAETGRARSAGWAVDIGREIQPGDPLDRVLGQIMAADTRAMHDTAALLDLAEVGRAADAIARAPRVNIFGASGSALVGEEMRSCLHRIGIPAWAWRDVHDGLAAASLLGTGDVALGVSHSGQTRETIELLAEAGSHGATTVALTSFPSAALAELADIVLLTATQATTFRPDALSARHPQLVVLDLLYIAVAQRTHSRAHAAFQRTAQAVDGHKAARDGSA
>NZ_CP022961.1|WP_095565987.1|4486208_4487660_-|carbohydrate-ABC-transporter,-N-acetylglucosamine/diacetylchitobiose-binding-protein
MSVTPDRPSDLTRRTLLGRTAAAGLLVTPAAGLLSACATSGSDDTGKKDGAEGTKSDQNPLGVKEDAALEVIIFNGGYGEKYATDVHEPLYKKEFPKAEIKHQSTQAISTVLQPRFAAGNPPEFVNNSGEKLMDFGALVKDGQLQDLTELWDAPSVDDPSKKVRDTVVPGTVEQGMYDTGDGAKPYVLYYVSTVYGLWYSGKLFQSNGWQPAKTWDEFMGLLDKIKGKGITPYGYAGANAAYYQWNVILTHAAKIGGADVLKNIDNLTPGAWTADPVLKAATAWAEVGAKYLDKSFEGLKHTDVQLQQDQYKVGFYPSGDWLENEQKQNTPPDFQYQLTTMPDLTSADAMPFGALRAAAGEGYFVSARSNNPRGGMEYMRQMLSTAGAKGFTETVKAATVVPAGSEGYAFPPGVASSQAALKAAGANVVNLMFDNWYKELDTECRTATNELMFGRVKAEQFCERMQKRADALTKDDSVAKFQR
>NZ_CP022961.1|WP_095565986.1|4485284_4486193_-|sugar-ABC-transporter-permease
MRHGKYPFVVGFLAAPVTLYAVFVIAPYAQAFQISMTDWRGFSAPNYIGFENFRRLFHDHRFWQAIEHHGILLLALPLITIAIALFFAFLLNVGGRSRGGQRRGVWGSNFYRVVFFFPQVLAVAIVAVLFQTVYRPNSSGLINGVLMKLGLDPVLFLVRPSLALWSIIAVLVWQAVGFYVVLFSAGMSAIPPDIYEAAEMDGATRVTLFFRVTLPLLWDTLQVAWVYLGIAAFDAFAIVSVLSVDNGGPDGATTVLALEIYRNAFVYSKYGYASAMGVALFFLTLTFAALTLRLSRRESVEY
>NZ_CP022961.1|WP_095565985.1|4484343_4485285_-|carbohydrate-ABC-transporter-permease
MNPHTTTQVTAPAPSAGAAGGLAAGALPDGRRRRRGRSEVSVLTGLGQAALIIWAILVIAPILWTFLASFKNTTEIFSSPWTMPDHLRWENWSRAWTKAHVGRYFLNSVLVVSLSTFGTMLLGSMAAYVLARYRFWGNRFIYYMFVSGLAFPVFLALVPLFFVVRNLHLLDSYTGLVLVYIAYSLPFTIFFLAAFFKTLPSSVAEAGLIDGASHTRLFFQVMLPMAKPGLVSVAIFNVIGQWAQYQLPLVLLSNAKDKWVLTQGIADISVNAGYEADWSGLFAALTIAILPMIVVYAIFQRQIQSGLTSGAVK
>NZ_CP022961.1|WP_095565995.1|4499068_4499269_-|DUF397-domain-containing-protein
MDLGNAIWKKSTRSGTSGGDCVEVAGNLPGIVGVRDSKDPAGPALVFRPGAWQGFVDLAKRIGPVG
>NZ_CP022961.1|WP_095565996.1|4499255_4500005_-|helix-turn-helix-domain-containing-protein
MRIAAELNQEEFGRRINYSSSTVSAIETGARPLDRMFLRRADDILGTDGLLASLLKMADRDREPSWFRPWLEAERSASQLRYFNPTLVPGLLQTANYARAVLRFDPTRPEEEVERQVAARLERQEILGRDQPPLVVAVIDESALRRRDAIMAEQLAHLLRLAELPHLQLHVIPADAGMYVGLSGPLALARSAEGGWVGHLENQLAALVVDAEDGIATLLARWEGVRGVALPHALSIALVKEVQSQHGPR
>NZ_CP022961.1|WP_095565997.1|4500329_4500632_+|hypothetical-protein
MLRRRNGTTVHRAYHVPLRPTWLCRICAAPWPCGSAKLALLAGHGRDQISLMMTLAHYLHEALYDLAEVCGPHAPAPQRLHARFLGWVTRPHRQPRGRAP
>NZ_CP022961.1|WP_095565998.1|4500797_4501628_-|hypothetical-protein
MDEQPERRTGAEDPRAVLAERFDPPPGLLPPRPTRVPDDPRRMSPLQASLVRPVRVVGRVGLNLLPFFDEPDPVRPASNTSWVWSLRRFARSAVWLLPGYAVLLAISTAGADGLRRSATFSAGAGLRVLGLALATWVGLLALTALTGLLATARTRGTATAGLLLAMFGALLLPLAPLGGPGFVRVLALLGGGVLTLGWVLAGLAVARSGVFGAFDGTLLVIAAPMIGLGGLLLGILQTVGALLVLAAGIGIAAKTGRLLPKPGSTLAPEPSGGAPA
>NZ_CP022961.1|WP_095565999.1|4501891_4503016_-|SPFH/Band-7/PHB-domain-protein
MGTAIAVLVGAVALIVVITLIRAVRIVPQQRMDVVERLGRYKRTLSPGLNLLVPFIDAVRTKVDMREQVVSFPPQPVITSDNLVVSIDTVLYFKVVDPVRATYEISNFLQAIEQLTVTTLRNVIGSLDLERALTSREEINRHLSVVLDETTGRWGVKVTRVEIKAIEPPPSIRDSMEKQMRAERDRRAAILNAEGLKQSQILTAEGEKQAAVLRADGDRQSRILQAEGQAKAIRTVFDAIHTANPSQKVLAYQYLQALPQIAAGQANKVWIVPAELTKALEGLGGALGGLSGTAGDTPSAEVDSGAVEREAREAAAAAAAAAAEVNHEVRAAEAQVSSGDKTQQLTAGQPVAPGSLVGESQPEQEPDSERTQRL
>NZ_CP022961.1|WP_095566000.1|4503027_4503495_-|NfeD-family-protein
MEPLLWIVLGAALAIAELFTTTLFLIMFSVGAFAAAGAAALGAPVSVQALVFAVVSVLTVLLGRPGLQRRRLAQEDGEGRPFGAAAIEGQRALVLERVDTDSGQVKIDGELWSARSFDATQVFEPGERVQVIEVRGVTALVWRDDFSASGELPES
>NZ_CP022961.1|WP_095566001.1|4503578_4504895_+|serine-hydrolase
MTLLPETTHRIDTIVTEAQAAGAIPSLIVGVVRDGRLAHVSTAGSQPAADPDMQYRIGSISKTMTAVLLLSQRDAGRLALDDPLERHLPGTPVGTVTLRQLLGHASGLQREPDGSWWERTEGADLATLVAGLTAGKLTHPPQTVYHYSNLAYGLLGGVLERLTGQPWWELVRTRLLDPLGMARTTYQATEPFARGYVVHPWNGTMREEPRTDTGAMAAAGQLWSTPADLARWAAFLADPDPAVLRPETLAEMCLPVIMSEPDSWGHGHGLGIELTRSGDRVYVGHGGSMPGYLAALGVHRPSRTGLVAFANCYNPRTLHLGANAVELLDLVLDADPPAPAQPWSAAGDPPRDAADLLGRWWWMGKEFTASWDADNDELVFAPQGRLPWRLTRAGTDRWRCHSGMNNGEFLTVRRDPAGRPDTVDIATFVFSRDPDRVG
>NZ_CP022961.1|WP_095566002.1|4505028_4507404_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MSGIAGPAALASRFGRISLWLALGLGTAVLLTETAWLVLRLPDAATASDAAATLVAGIAAGCCLAVSRRHPANLRRFWLLMALTMALAATGRIIWTVTRLTTGGGLPNNLAVALVFVAGIVSGTAALLSCVSAPPTAAGRLRTLLDGVIVGLALVPVSWVVVLRDVAAAPLAETPRTLGLFYPMFDVMQLTILVAISGPLRPVWRPLSTIGAGLAIRAVADTVYVAQIARGTYEAGHPIDVCWPLSYLLVAVATRYPAPGGIDPAGGAETEPDADPPIVPWWRLALPYLPVCGAAVAMVLARQPGQPLPPPVFLAGTGLLVALAIRQSLTAYETTNLADRLRRLAYVDQLTGLPNRLQFTRRLRRCIRERRPVAVLLLDLDGFKQVNDRFGHASGDTLLTNVASRMRAVVGGSGMIARIGGDEFAVLLETGDDPGPARPAGPDRETDPGPGRTAERDPDRLARRLLAALGPGGPKADWLLHSSASIGIAEYGPQHQGHTDLLRDADIAMYAAKAAGKSAYRTCTPRLREAAVGRAELIADLRRAVLEAEQLELEFQPIVELGTGTVRGAEALVRWRHPRHGLLAPDRFLPLAEETGLILTVDRWVIRAACRAAAGWQLLSPGTTVAVNVAAGHLRRADLTETVAEATAAAGLPPESLTLELTETALIEGTEAVLDRLGQLRDLGVRIALDDFGTGYSALNYLHRIPATELKIDRSFVRRLDGSDQRAYATVEMIRRLAGAFGLGVVAEGVETDAQHAAVAEIGCPHGQGYRYGRPRPLPDLHRLLVAQRPG
>NZ_CP022961.1|WP_095566003.1|4507416_4508232_-|DUF3097-domain-containing-protein
MGRRYGEDVLAGDWRRRRVTPEVDAEPDLVVEDADSGFCGAVVGFEQGAVVLEDRHGRRRNFPLLPAAFLLDGEAVTLRRPAARPAPAPRRRTASGSVAVAGVRARVAQASRIWVEGVHDAALVERIWGDDLRIEGIVVEPLDGIDALADRVREFEPGPRRRLGVLVDHLVSGSKESRIVAAVTSPDVLVTGHPYVDVWQAVRPRALGIPAWPVVPPGRPWKEGVCAALGVAEPAAMWRHILSRVDSFADVETPLINAMERLIDFVTVPPG
>NZ_CP022961.1|WP_095566004.1|4508360_4509152_+|hypothetical-protein
MSAPTDAVTLAPRRSSRFVAWVRAWRTGLVPFDEVADEIADGEEHLVADAPGTWTDVPLTEALPVLSRTPPDRVRLVLPVPGDPRGLPGPGPFAGAALLAGEAVVAGDLGVIPEVRSHTSGSGMTFETVLWRVYPLPAGAAAAARHEPGAAEAEAELAAALAEATAALTRLDVAAWRPELAGALAALRRPDSCKDLPPGFDPRARRLFARASVLDRVLALAEHAAPGGAVNGYEAQQRDAALRPLTAACRRALVAACNAPLRP

Crispr_ID: NZ_CP022961_25

• CRISPR_ID: NZ_CP022961_25
• CRISPR_location: 4922027-4922108
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_25

Consensus_repeat	Method
CTTGCGGGCCGGCGCCTTCTTGGC	CRISPRCasFinder

spacers of NZ_CP022961_25

>25.1|4922051|33|NZ_CP022961|CRISPRCasFinder
CGCCGCGCTCGTGCCGGTCCGGGTGGACGTGGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_25

CRISPR arrays

The CRISPR arrays of NZ_CP022961_25

>merge|NZ_CP022961|25|4922027-4922108|CRISPRCasFinder
CGTGCGGGCGGGCGCCTTCTTCGCCGCCGCGCTCGTGCCGGTCCGGGTGGACGTGGCCTTCCTCGCCGGCGCCTTCTTGGCG

>NZ_CP022961|25|26|4922027-4922108|CRISPRCasFinder
CGTGCGGGCGGGCGCCTTCTTCGC	CGCCGCGCTCGTGCCGGTCCGGGTGGACGTGGC
CTTCCTCGCCGGCGCCTTCTTGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|273198
NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter	unknown	unknown	gnl|CDD|223664
NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240032
NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP022961.1|WP_095566271.1|4922665_4922896_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase	unknown	unknown	gnl|CDD|132882
NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein	unknown	unknown	gnl|CDD|227922
NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase	unknown	unknown	gnl|CDD|273873
NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320687
NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234723
NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238564
NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|223252
NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein	unknown	unknown	gnl|CDD|371707
NZ_CP022961.1|WP_095566274.1|4925057_4925270_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein	unknown	unknown	gnl|CDD|379389
NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|227253
NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase	unknown	unknown	gnl|CDD|237577
NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein	unknown	unknown	gnl|CDD|377640
NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase	unknown	unknown	gnl|CDD|180903

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase	gnl|CDD|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter	gnl|CDD|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	1.64396e-57
NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein	gnl|CDD|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.40671e-49
NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.71949e-36
NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase	gnl|CDD|273873	TIGR01915, F420-dependent_NADP_reductase, NADPH-dependent F420 reductase. This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport].	7.26063e-71
NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase	gnl|CDD|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	3.50851e-114
NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	9.46981e-09
NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein	gnl|CDD|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	3.86619e-08
NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease	gnl|CDD|320687	cd07328, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase. This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.	7.09683e-27
NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl|CDD|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	2.62054e-156
NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.37919e-19
NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein	gnl|CDD|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.71203e-49
NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase	gnl|CDD|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein	gnl|CDD|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	9.63843e-92
NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein	gnl|CDD|227253	COG4916, COG4916, Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown].	1.21667e-11
NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase	gnl|CDD|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein	gnl|CDD|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	2.93825e-10
NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase	gnl|CDD|180903	PRK07238, PRK07238, bifunctional RNase H/acid phosphatase; Provisional.	1.42359e-167

Protein sequences

>NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase
MAYDASSFPDVTGLTLAIIGGTGDQGRGLAYRFVRAGQRVLIGSRSAERAGQAAAEIAALPGLPAGTEVAGMANADAAAGADVVIIAVPWDGHGDTVAQLREPLAGKIVIDCVNPLGFDKHGPYPLPVPEGSAVQQAAALLPESRVCAAFNHVSAPLLADPEVDRIDLDVLICTEDREVAGVVAALAARIEGMRGIYAGRLRNAHQIEAFTANLIAINRRYKTHAGIRVTDL
>NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein
MPAPPRRVVSLVPSLTEAIAVTAPELLAGATDYCTHPAGLDVPRVGGTKYPDLERILAADPDLVVANAEENRREDVEALRAAGVPVWVTFPRTLDAALVSLDRLLAALGRTTGPPWLAAARAAWAAPPVPAGRRRAVVPVWRRPWVVLGSGTFAGDLLARLGVRNCYADAAQRYPRPALSELLDQRPELVVLPDEPYPFSDRDGPEAFAGIPAALLSGRHLTWYGPSLAEAPALLAAQLAAANPR
>NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MVESTPAEVTALYGGPATRRVRTRDLLAAKERGERWPMLTAYDQYTAAIFDQAGIPVLLVGDSAANNVFGYETTVPVTAEELLPLVRAVVRSTRHTLVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEGGRRCAAQIAAISGAGIPVMAHVGFTPQREHAIGGYRVQGRGDAAEEVIADARAVAEAGAFAVVLEMVPGEVAKRITAQLPIPTVGIGAGPDTDAQVLVWQDMAGLRSGRMPRFVKRYADLAGALTEATRQFASEVRDGQFPAAEHTF
>NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase
MPTLRLALAQVNPTVGDLAGNADIVRRSARDAADAGAHLVAFPELMLTGYPVEDLVFRSSFVRASQHALRELAAGLATDGLGELPVLVGYLDADGPPATRADAIPDHGARNAMALLHGGQIRATYFKHHLPNYGVFDEDRYFVPGQTLTVVRVGGVDVALTICEDMWQAGGPFAVARRADVGLVVTINGSPYELNKDDVRLPLVRRRAAEAGATIAYVNMVGAQDELVYDGDSMIVAADGTLLARAPQFVEHLLVHDVQLPAAGTGDTPPGSPPGSPAGGPAEMDVRRITLSDAVPAPAGPSASGEISEPVPDEAEVWNALVLGLRDYVDKNRFPSVILALSGGIDSALVATLAVDALGPDRVVAVSMPSRHSSEHSKTDAADLAKRTGLDFRTEPIQPMVDTFLANVSLSGLAVENLQARVRGVLLMALSNQEGHLVLTTGNKSELAVGYSTLYGDSVGGFNPIKDVWKTLVWKLARWRNEEAVRRGETPPIPENSIVKPPSAELSPGQLDTDTLPDYSMLDGILTGYVDGDAGRDDLIAAGHDADLVDRVLRMVDIAEYKRRQSAPGTKISIKAFGRDRRLPITNRWREHGV
>NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase
MDRQQEFVLRTLEERDIRFVRLWFTDVLGTLKSVSVAPAELEAAFDEGIGFDGSAIEGFARVFESDMIAMPDPTTFQVFPFEGGVSGESARMFCDILLPDGSPSWADPRHVLRRALSRAAEKGFTFYTHPEIEFFLLEDGIADGSVPVPVDTGGYFEHTTHAVARDFRRQAVLALERIGISVEFSHHEVAPGQQEIDLRYADALATADNIMTFRHVVKEVALSTGVHASFMPKPFTDQPGNGMHTHLSLFEGERNAFHDAGDPMKLSKVARAFIAGLLRHAREYTAVTNQWVNSYKRLFPLTLPDRITESPAYVCWGHLNRSALVRVPAYGKPTSARVEVRSIDSATNPYLAFAVLLGAGLKGIEEGYDLPPGAEDDVWSLSNAERKAMGYEALPENLAEAIDVMAGSELVAEVLGEHVFDYFLRNKRAEWEEYRREVTPYERRRYLSL
>NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein
MSDTLSYADAVRLLGGGENRWVDLIDRMAGGAVLSAAIPVPGLADANVGLVGLGRELLRAVAERRSGLSRYDRTRRLEAAHAVIAVTAYFEALAEVGPPDLLSELDVVRSEQLALAGARPTDPRSTLEAMFALPVPVPGPALPYPRLRGELRTFYTELAGRLTLFTADLREGTAPPWHAIDPLNRAIELGLDRHRELLTRLAGDFPEVGFWIGLHEQEATRAEVRALGTGLAELRAELDRISTGAGPDARRAALATAYTAELDRPIAASGDVPAGLRLPTLGGAYVPPLFRVAELGVAARPAEEEWWADRPLRGDLAEFLVGQLTSPGAVRAPLLVLGQPGSGKSVLTKILAARLPAADFLAVRVVLRDVPAAADLQEQLEHAIRDATGDRPDWPALASAAGDALPVVLLDGFDELLQATGVSQTDYLTRVAEFQRRESVQGRPVAVLVTSRTSVADRARPPAGALALRLEPFDPARVQRWLDTWNETNAGLPGFTPLPAEVALRHRELAEQPLLLLMLALYDAGGGDLRAAGDLRHAELYERLLDNFARREVVKQRELTGRELDRAVEDELRRLSVVAFAMFNRRAQWSTEDALEADLAALPFDGAAVVARDDRRTPLRAAEIVLGRFFFVHRSQASRDADRPIAYEFLHATFGEYLVARLTWQVVENLVAVDRAASLAPGGPRVDDDLLYALLSHAVLTSRAPVVGFLAERLSILDDELRAGWADLLVRLFRTVNHRTGPRALDGYRPLPLPVPARYAAYAANLLVLAVCAAGEITGSRLYPEADDPVPDWHAQALLWRSQLHPEEWSSLVAALELGRRADGQVRDVALRLDSGAAAPPIDLTWTYSWPGDGELLELASSKASGQPAAVLRRKTYFECGINGDVLQHALDPLVEAAPWALTRYVSTIGRGAETAHSVAWILLAAMLGPVTGQPLVELRSVRQYLDLGLDDAADDPSGSEAPEQSRLRLLGLLLDRLSADASGPVAVAVDLLDQAVPLLNPVHDLAEPVLRCCLAFLGRGDRNEDRAIADVVARAIGQAGQSRLWTGELALEARVRLHELGVRTLPIAPQHVEALTALHQRRRPDLLVRMRPLIQPAD
>NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase
MLVSPSGPTRPERVARGVELLTGWGLRPLLAPHAYARHGYLAGTDELRAADLNTAFADPEIRGVLCTRGGYGAQRVVDAIDMAAVRRDPKVVAGFSDITALQFALWRGARLASVHGPGAAWLDERTPLTSAESLHAALMSTEPVSVVRSAEEETARLVVPGVATGPLLGGNLCLITASLGTPDMPDLTGAILLIEEVEEQPYKVDRMLTHLRRAGALDGVAGVAVGQFTRCADDWPVTVVDVLAERLGDLGVPVLGGLPVGHGVGQLTVPVGTPATLDAVTGTLTVTAAVR
>NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase
MFANPEELLRYLKNEDVKFVDVRFCDLPGVMQHFNLPVESFDESIFETGLAFDGSSIRGFQAIHESDMLLLPDVATAFVDPFRTQKTVALNFFIHDPFTREAYSRDPRNVAKKAEAYLAASGIADTAYFGPEAEFYIFDSIRHETSAHQAYYYIDSVEGAWTSGREEEGGNRGYKTAYKGGYFPVPPVDHYADLRDQIVRKLVDTGFTVERSHHEVGTAGQAEINYKFSTLLHAGDQLQLFKYIVKNTAWAAGKTATFMPKPLFGDNGSGMHTHQSLWMNGEPLFYDETGYGGLSDTARWYIGGLLHHAPSLLAFTNPTVNSYRRLVPGFEAPVNLVYSQRNRSACTRIPVTGSNAKAKRVEFRVPDPSANVYLAFSAMMMAGLDGIRSKIEPPQPIDKDLYDLPPEEWGSVKQVPGSLPEVLDALEADHDYLLDGGVFTPDLISTWVDYKRANEVDPVRLRPTPHEFEMYYNV
>NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein
MAGRLPGRITYVSVVLRPRSTIPPACGYGVDAGLCAVRLPWLAVTRQQDGEPVTHGTDPAGTDRADPAPGIEPASLGRRFGALIIDWVLCLLVGSMIADPVRAGWPPVLVLILEYGFFLGLFAQTPGMFLTRIACVSHRDGGRIGIPRALLRGLLLALLVPALIMDDQRRGLHDRWSGSIVIPVTPRSAG
>NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein
MATPQEKVSFGQRLKQIGMVFSFTAKQDRLFIPLVVVAVLVPLALTVVVAIVWGWMWVPVGVLLALLAVLIVLNLRSNRAMMSAAEGQRGAAAQIVENMRGDWRVTPAVSATTQMDMVHLVIGKPGVVLLAEGNPQRVRGLLGQEKRRLSKVIGSAPLYDYLIGSGENELPIRKLRTTLMRLPRNLSGKDVNALDKRLKALSARPQMPKGAIPKNMRPPRGAFRQTRGR
>NZ_CP022961.1|WP_095566271.1|4922665_4922896_-|hypothetical-protein
MRDAVHSIPMSDSGRGAQYFWCTRHHRVETEADVCPARYVLGPYASAADAANALEQVRERNEAWDAEDVRWAGEER
>NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease
MVGKTSAAAASTPAACARCARPTVSLGSATPWCGHCEWNLDRYDEASTDPEFGWVWVDRRLRGIAYRLSRRQYAELAAAAGGRSRYGAARIVLVVASVLLLGAFAALVAASCWLLWRYPLLSLYTVLAALGLATAVLMRPRLGRLHPLARVVDADRAPELHRLIREVADVVGVPPPHVVAVDESFSAYTSAVGPRRRRVLCLGLPLWAALAPQERVALLGHELGHFANGDIRRGLLTQPAFTMLGHAAQILSPVSTHNPGGGLIGLLTDLVSRVVLWTLSRLVLAGHLLLLWVGLRDGQRAEYRADELASVAAGSTAAVGLMDTLVGMDVVQMMVCREARAGLGPADWRAVVANTRVESAAQLPLRRQLSIRRDVSLFASHPPSGLRARLVEARPHRDPRIVLTEDRAARIDAELAAEFAAVRRELAVVG
>NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein
MAIPDYIVRMRKHVGTDLLWLPSVSAVVLNEHGELLLGRRADDGRWSVISGFVEPHEQPAQAVVREVEEETGVLVAPERVSSVWAHPHRYPNGDHCQYLNIGYRCRKLGGEARVNDDESTDVRWVPLDRLPDLDEHARLTIEHALADQPAAWFADN
>NZ_CP022961.1|WP_095566274.1|4925057_4925270_+|hypothetical-protein
MSGVSTLFIGGPADGVRQDLPADPDGRPPARWVLRGHDAPGDHLYERAGPDPRGGWTMHHVRTDPAGMSE
>NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase
MARAEVFTDEQRLRRIEAVTDATLSRLDVADLFDELLDRVRDLLRVDTAVILLLDARAQQLVATAARGLEEEVRQGFRLSVGRGFAGRVALTRRPLIIPNVTASDVVNPILLEAGIRSLLGVPIIARGDLIGVLHVGTLRPRRFTPDDVRLLELVADRISLASRARASSLDQAAALALQRSLIPTELPDVPGLELAARYVPGHACGVGGDWYDVFTLPSGWHGVVVGDVSGHGLQSAVVMGRVRSALRAYALVCDDPAEALTLLDRKVVHFEAGSLTTALYAMISPDGATLRISLAGHPRPVLALPGRPNGLLAGHIDPPLGIGRQHPCRHTTTVDFPPGAVLVSYTDGLVERRGEVFDDGVDRLLAAIPLAPAETVTATVMATLDTEHPADDIALLAIRRLPERHGTA
>NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein
MAIPYLEDVFKISGVPSYTFVRPSEFNRLKVALRTPGRGVVVEGPSGIGKSTAATKVLEELGLDGSVVKLSARVPADIEYIEMLPELGDFGTVIVDDFHRLTDSTKARIADLLKVTADMEHTRRKLVVIGINDAGRALIKSAPDLSNRIDIIRFEVEPASKIEELVSAGETALNVQLDARDLIIEKARGSFYLAQLLCWDACVQAEVTEKAQNRQSISTSYAAIQRRVVERQKERFGPAVRSFARGTKFRPSGRAPYLHILKWLSESESWSISIQDEMRKHPNEKASVGVVLEQGYLAKLTEKSDIAEILHFDPDSKVLAVENPLLIFYLRNISWPQFVRDVGFTKIDYKENYDFALSFAGEDRAYAENLRNRLEDNGHSVFYDFAEQHRFLGQDIETYMGPIYASDSRCVVAVLGEMYGKKRWTLFESSQFENRIEPGEVVPIWSTKVPPTSFDTTRQRGGLEFDPEGDLIQQAAAHAEILSRMIAERT
>NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein
MDLSQAALLVVAGLAAGVMNAVAGGGSLITFPALIAIGLHPVAANVTNSISVSPGYLSSVAGSRQDLPERRRLLPLIPTAVLGALAGSALLLVTPARAFELVVPFLVLGASAALAFQSRLRRLVGHPAELSPRRRAVTVQLMVAAGSVYGGYFGAALGVMLVAGLALVLDETLVRVTAVKNLLSALVGLSTVVVFGLFGPVNWVAVAVLVPATIVGGYAGARLARRLAPAVLKAVIVIFGTGIGLLLLYRALR
>NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter
MWKDHLTEIIVFSLLFLLVSAMGFVAARWRAPNDMAHLDEWGLGGRSFGGWITWFLVGGDLYTAYTFVAVPALMFGAGAAGFFAVPYTIIIYPLVFLVLVRLWSVSHRHGFVTPADFVRTRFGSPTLALLVAITGIVATMPYIALQLVGIEAVLKTMGVTGDNAIARHLPIILAFAILAAYTYQSGLRAPALIAFVKDSLIYIVILVAILWLPHKLGGWSSIFDAADAKFKATPSPADGIVLNANNQVQYITLAFGSALALFLYPHSLTGVLASKNRDVIKRNMSALPAYSLLLGLIALLGFMAIAAGVKPLPGAKPGTADSNTVVPLLFDMQFPDWFAGVAYAAIGIGALVPAAIMSIAAANLFTRNIYKEYLKRDATAAQEATVAKIASLVVKVGAVACIVFLDPQFSIDLQLIGGIIILQTLPAVALGIYTRWFHRGGLIAGWVAGMGMGMWMLYQIGNPTTGKKHFAGSAFPLSEFGFDTKKTIYVGIVAVLVNLLVAVLVTLALRAGRVADGPDGTTHDDYFADEGDPRVTPGGREDAEAAPEPVA
>NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein
MGESVAGEPPRPADPDTAGSGPLGGDPAQTALSEAKDRSPWNWLLFVPIVVPLITPLFNRDAPRLLGFPTFYWLQLAFIVLGVATTTVVYQMTKKRR
>NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase
MAVDRVVVEADGGARGNPGPAGYGAVVRDDRDGQVLIERSDAIGVATNNVAEYRGLIAGLEAAAELGASRVAVRMDSKLVVEQMCGRWQIRNQGLRPLAARAAALVSRFAAVDFEWVPRDRNRHADALANAAMDQAASGSAGSAGSAGSRTNGSAANGSAAEADPGPRAGAPVSWEPRPSSTATRLLLVRHGETEFTARRRYSGRGDVPLTDLGRRQAAAVAGRVAGLCAQVAAVVSSPLGRCTATARSIAAATGDPPLVIRDDLIECDFGEWEGRTFAEVHERWPAEQADWLGSPAVAPPGGESFVEVATRVRRAVADLVAAYPKATIAVVSHVSPIKLILRDALAAGDSFLHRLYLDAAGLSVVDYWPDGGVAVRSVNEVAHLAD

Crispr_ID: NZ_CP022961_24

• CRISPR_ID: NZ_CP022961_24
• CRISPR_location: 4921727-4921925
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP022961_24

Consensus_repeat	Method
CTTGCGGGCCGGCGCCTTCTTGGC	CRISPRCasFinder

spacers of NZ_CP022961_24

>24.1|4921751|57|NZ_CP022961|CRISPRCasFinder
CACCGCGGCCTTGCGCATGCTCGGCCGGGTGGATCCGGCGTTCGCGGCGGCGCTGGT
>24.2|4921832|24|NZ_CP022961|CRISPRCasFinder
CGGCGCCCGCTTGGCCGCCGTCGT
>24.3|4921880|21|NZ_CP022961|CRISPRCasFinder
GGCGGACTTGGTCGCCGCGCT

CRISPR arrays and Neighbor proteins around NZ_CP022961_24

CRISPR arrays

The CRISPR arrays of NZ_CP022961_24

>merge|NZ_CP022961|24|4921727-4921925|CRISPRCasFinder
CCGTTTGGCCGGCGCCTTCTTGCCCACCGCGGCCTTGCGCATGCTCGGCCGGGTGGATCCGGCGTTCGCGGCGGCGCTGGTCCTCTTGGCGGGCGCCTTCTTCGCCGGCGCCCGCTTGGCCGCCGTCGTCTTCTTCGCCGGCGCCCGCTTGGTGGCGGACTTGGTCGCCGCGCTCTTGCGGGCGGTGGCCGTCTTGGCG

>NZ_CP022961|24|25|4921727-4921925|CRISPRCasFinder
CCGTTTGGCCGGCGCCTTCTTGCC	CACCGCGGCCTTGCGCATGCTCGGCCGGGTGGATCCGGCGTTCGCGGCGGCGCTGGT
CCTCTTGGCGGGCGCCTTCTTCGC	CGGCGCCCGCTTGGCCGCCGTCGT
CTTCTTCGCCGGCGCCCGCTTGGT	GGCGGACTTGGTCGCCGCGCT
CTTGCGGGCGGTGGCCGTCTTGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|273198
NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter	unknown	unknown	gnl|CDD|223664
NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240032
NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP022961.1|WP_095566271.1|4922665_4922896_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase	unknown	unknown	gnl|CDD|132882
NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein	unknown	unknown	gnl|CDD|227922
NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase	unknown	unknown	gnl|CDD|273873
NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320687
NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234723
NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238564
NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|223252
NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein	unknown	unknown	gnl|CDD|371707
NZ_CP022961.1|WP_095566274.1|4925057_4925270_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein	unknown	unknown	gnl|CDD|379389
NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|227253
NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase	unknown	unknown	gnl|CDD|237577
NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein	unknown	unknown	gnl|CDD|377640
NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase	unknown	unknown	gnl|CDD|180903

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase	gnl|CDD|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter	gnl|CDD|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	1.64396e-57
NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein	gnl|CDD|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.40671e-49
NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.71949e-36
NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase	gnl|CDD|273873	TIGR01915, F420-dependent_NADP_reductase, NADPH-dependent F420 reductase. This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport].	7.26063e-71
NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase	gnl|CDD|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	3.50851e-114
NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	9.46981e-09
NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein	gnl|CDD|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	3.86619e-08
NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease	gnl|CDD|320687	cd07328, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase. This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.	7.09683e-27
NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl|CDD|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	2.62054e-156
NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.37919e-19
NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein	gnl|CDD|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.71203e-49
NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase	gnl|CDD|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein	gnl|CDD|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	9.63843e-92
NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein	gnl|CDD|227253	COG4916, COG4916, Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown].	1.21667e-11
NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase	gnl|CDD|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein	gnl|CDD|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	2.93825e-10
NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase	gnl|CDD|180903	PRK07238, PRK07238, bifunctional RNase H/acid phosphatase; Provisional.	1.42359e-167

Protein sequences

>NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase
MAYDASSFPDVTGLTLAIIGGTGDQGRGLAYRFVRAGQRVLIGSRSAERAGQAAAEIAALPGLPAGTEVAGMANADAAAGADVVIIAVPWDGHGDTVAQLREPLAGKIVIDCVNPLGFDKHGPYPLPVPEGSAVQQAAALLPESRVCAAFNHVSAPLLADPEVDRIDLDVLICTEDREVAGVVAALAARIEGMRGIYAGRLRNAHQIEAFTANLIAINRRYKTHAGIRVTDL
>NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein
MPAPPRRVVSLVPSLTEAIAVTAPELLAGATDYCTHPAGLDVPRVGGTKYPDLERILAADPDLVVANAEENRREDVEALRAAGVPVWVTFPRTLDAALVSLDRLLAALGRTTGPPWLAAARAAWAAPPVPAGRRRAVVPVWRRPWVVLGSGTFAGDLLARLGVRNCYADAAQRYPRPALSELLDQRPELVVLPDEPYPFSDRDGPEAFAGIPAALLSGRHLTWYGPSLAEAPALLAAQLAAANPR
>NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MVESTPAEVTALYGGPATRRVRTRDLLAAKERGERWPMLTAYDQYTAAIFDQAGIPVLLVGDSAANNVFGYETTVPVTAEELLPLVRAVVRSTRHTLVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEGGRRCAAQIAAISGAGIPVMAHVGFTPQREHAIGGYRVQGRGDAAEEVIADARAVAEAGAFAVVLEMVPGEVAKRITAQLPIPTVGIGAGPDTDAQVLVWQDMAGLRSGRMPRFVKRYADLAGALTEATRQFASEVRDGQFPAAEHTF
>NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase
MPTLRLALAQVNPTVGDLAGNADIVRRSARDAADAGAHLVAFPELMLTGYPVEDLVFRSSFVRASQHALRELAAGLATDGLGELPVLVGYLDADGPPATRADAIPDHGARNAMALLHGGQIRATYFKHHLPNYGVFDEDRYFVPGQTLTVVRVGGVDVALTICEDMWQAGGPFAVARRADVGLVVTINGSPYELNKDDVRLPLVRRRAAEAGATIAYVNMVGAQDELVYDGDSMIVAADGTLLARAPQFVEHLLVHDVQLPAAGTGDTPPGSPPGSPAGGPAEMDVRRITLSDAVPAPAGPSASGEISEPVPDEAEVWNALVLGLRDYVDKNRFPSVILALSGGIDSALVATLAVDALGPDRVVAVSMPSRHSSEHSKTDAADLAKRTGLDFRTEPIQPMVDTFLANVSLSGLAVENLQARVRGVLLMALSNQEGHLVLTTGNKSELAVGYSTLYGDSVGGFNPIKDVWKTLVWKLARWRNEEAVRRGETPPIPENSIVKPPSAELSPGQLDTDTLPDYSMLDGILTGYVDGDAGRDDLIAAGHDADLVDRVLRMVDIAEYKRRQSAPGTKISIKAFGRDRRLPITNRWREHGV
>NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase
MDRQQEFVLRTLEERDIRFVRLWFTDVLGTLKSVSVAPAELEAAFDEGIGFDGSAIEGFARVFESDMIAMPDPTTFQVFPFEGGVSGESARMFCDILLPDGSPSWADPRHVLRRALSRAAEKGFTFYTHPEIEFFLLEDGIADGSVPVPVDTGGYFEHTTHAVARDFRRQAVLALERIGISVEFSHHEVAPGQQEIDLRYADALATADNIMTFRHVVKEVALSTGVHASFMPKPFTDQPGNGMHTHLSLFEGERNAFHDAGDPMKLSKVARAFIAGLLRHAREYTAVTNQWVNSYKRLFPLTLPDRITESPAYVCWGHLNRSALVRVPAYGKPTSARVEVRSIDSATNPYLAFAVLLGAGLKGIEEGYDLPPGAEDDVWSLSNAERKAMGYEALPENLAEAIDVMAGSELVAEVLGEHVFDYFLRNKRAEWEEYRREVTPYERRRYLSL
>NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein
MSDTLSYADAVRLLGGGENRWVDLIDRMAGGAVLSAAIPVPGLADANVGLVGLGRELLRAVAERRSGLSRYDRTRRLEAAHAVIAVTAYFEALAEVGPPDLLSELDVVRSEQLALAGARPTDPRSTLEAMFALPVPVPGPALPYPRLRGELRTFYTELAGRLTLFTADLREGTAPPWHAIDPLNRAIELGLDRHRELLTRLAGDFPEVGFWIGLHEQEATRAEVRALGTGLAELRAELDRISTGAGPDARRAALATAYTAELDRPIAASGDVPAGLRLPTLGGAYVPPLFRVAELGVAARPAEEEWWADRPLRGDLAEFLVGQLTSPGAVRAPLLVLGQPGSGKSVLTKILAARLPAADFLAVRVVLRDVPAAADLQEQLEHAIRDATGDRPDWPALASAAGDALPVVLLDGFDELLQATGVSQTDYLTRVAEFQRRESVQGRPVAVLVTSRTSVADRARPPAGALALRLEPFDPARVQRWLDTWNETNAGLPGFTPLPAEVALRHRELAEQPLLLLMLALYDAGGGDLRAAGDLRHAELYERLLDNFARREVVKQRELTGRELDRAVEDELRRLSVVAFAMFNRRAQWSTEDALEADLAALPFDGAAVVARDDRRTPLRAAEIVLGRFFFVHRSQASRDADRPIAYEFLHATFGEYLVARLTWQVVENLVAVDRAASLAPGGPRVDDDLLYALLSHAVLTSRAPVVGFLAERLSILDDELRAGWADLLVRLFRTVNHRTGPRALDGYRPLPLPVPARYAAYAANLLVLAVCAAGEITGSRLYPEADDPVPDWHAQALLWRSQLHPEEWSSLVAALELGRRADGQVRDVALRLDSGAAAPPIDLTWTYSWPGDGELLELASSKASGQPAAVLRRKTYFECGINGDVLQHALDPLVEAAPWALTRYVSTIGRGAETAHSVAWILLAAMLGPVTGQPLVELRSVRQYLDLGLDDAADDPSGSEAPEQSRLRLLGLLLDRLSADASGPVAVAVDLLDQAVPLLNPVHDLAEPVLRCCLAFLGRGDRNEDRAIADVVARAIGQAGQSRLWTGELALEARVRLHELGVRTLPIAPQHVEALTALHQRRRPDLLVRMRPLIQPAD
>NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase
MLVSPSGPTRPERVARGVELLTGWGLRPLLAPHAYARHGYLAGTDELRAADLNTAFADPEIRGVLCTRGGYGAQRVVDAIDMAAVRRDPKVVAGFSDITALQFALWRGARLASVHGPGAAWLDERTPLTSAESLHAALMSTEPVSVVRSAEEETARLVVPGVATGPLLGGNLCLITASLGTPDMPDLTGAILLIEEVEEQPYKVDRMLTHLRRAGALDGVAGVAVGQFTRCADDWPVTVVDVLAERLGDLGVPVLGGLPVGHGVGQLTVPVGTPATLDAVTGTLTVTAAVR
>NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase
MFANPEELLRYLKNEDVKFVDVRFCDLPGVMQHFNLPVESFDESIFETGLAFDGSSIRGFQAIHESDMLLLPDVATAFVDPFRTQKTVALNFFIHDPFTREAYSRDPRNVAKKAEAYLAASGIADTAYFGPEAEFYIFDSIRHETSAHQAYYYIDSVEGAWTSGREEEGGNRGYKTAYKGGYFPVPPVDHYADLRDQIVRKLVDTGFTVERSHHEVGTAGQAEINYKFSTLLHAGDQLQLFKYIVKNTAWAAGKTATFMPKPLFGDNGSGMHTHQSLWMNGEPLFYDETGYGGLSDTARWYIGGLLHHAPSLLAFTNPTVNSYRRLVPGFEAPVNLVYSQRNRSACTRIPVTGSNAKAKRVEFRVPDPSANVYLAFSAMMMAGLDGIRSKIEPPQPIDKDLYDLPPEEWGSVKQVPGSLPEVLDALEADHDYLLDGGVFTPDLISTWVDYKRANEVDPVRLRPTPHEFEMYYNV
>NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein
MAGRLPGRITYVSVVLRPRSTIPPACGYGVDAGLCAVRLPWLAVTRQQDGEPVTHGTDPAGTDRADPAPGIEPASLGRRFGALIIDWVLCLLVGSMIADPVRAGWPPVLVLILEYGFFLGLFAQTPGMFLTRIACVSHRDGGRIGIPRALLRGLLLALLVPALIMDDQRRGLHDRWSGSIVIPVTPRSAG
>NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein
MATPQEKVSFGQRLKQIGMVFSFTAKQDRLFIPLVVVAVLVPLALTVVVAIVWGWMWVPVGVLLALLAVLIVLNLRSNRAMMSAAEGQRGAAAQIVENMRGDWRVTPAVSATTQMDMVHLVIGKPGVVLLAEGNPQRVRGLLGQEKRRLSKVIGSAPLYDYLIGSGENELPIRKLRTTLMRLPRNLSGKDVNALDKRLKALSARPQMPKGAIPKNMRPPRGAFRQTRGR
>NZ_CP022961.1|WP_095566271.1|4922665_4922896_-|hypothetical-protein
MRDAVHSIPMSDSGRGAQYFWCTRHHRVETEADVCPARYVLGPYASAADAANALEQVRERNEAWDAEDVRWAGEER
>NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease
MVGKTSAAAASTPAACARCARPTVSLGSATPWCGHCEWNLDRYDEASTDPEFGWVWVDRRLRGIAYRLSRRQYAELAAAAGGRSRYGAARIVLVVASVLLLGAFAALVAASCWLLWRYPLLSLYTVLAALGLATAVLMRPRLGRLHPLARVVDADRAPELHRLIREVADVVGVPPPHVVAVDESFSAYTSAVGPRRRRVLCLGLPLWAALAPQERVALLGHELGHFANGDIRRGLLTQPAFTMLGHAAQILSPVSTHNPGGGLIGLLTDLVSRVVLWTLSRLVLAGHLLLLWVGLRDGQRAEYRADELASVAAGSTAAVGLMDTLVGMDVVQMMVCREARAGLGPADWRAVVANTRVESAAQLPLRRQLSIRRDVSLFASHPPSGLRARLVEARPHRDPRIVLTEDRAARIDAELAAEFAAVRRELAVVG
>NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein
MAIPDYIVRMRKHVGTDLLWLPSVSAVVLNEHGELLLGRRADDGRWSVISGFVEPHEQPAQAVVREVEEETGVLVAPERVSSVWAHPHRYPNGDHCQYLNIGYRCRKLGGEARVNDDESTDVRWVPLDRLPDLDEHARLTIEHALADQPAAWFADN
>NZ_CP022961.1|WP_095566274.1|4925057_4925270_+|hypothetical-protein
MSGVSTLFIGGPADGVRQDLPADPDGRPPARWVLRGHDAPGDHLYERAGPDPRGGWTMHHVRTDPAGMSE
>NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase
MARAEVFTDEQRLRRIEAVTDATLSRLDVADLFDELLDRVRDLLRVDTAVILLLDARAQQLVATAARGLEEEVRQGFRLSVGRGFAGRVALTRRPLIIPNVTASDVVNPILLEAGIRSLLGVPIIARGDLIGVLHVGTLRPRRFTPDDVRLLELVADRISLASRARASSLDQAAALALQRSLIPTELPDVPGLELAARYVPGHACGVGGDWYDVFTLPSGWHGVVVGDVSGHGLQSAVVMGRVRSALRAYALVCDDPAEALTLLDRKVVHFEAGSLTTALYAMISPDGATLRISLAGHPRPVLALPGRPNGLLAGHIDPPLGIGRQHPCRHTTTVDFPPGAVLVSYTDGLVERRGEVFDDGVDRLLAAIPLAPAETVTATVMATLDTEHPADDIALLAIRRLPERHGTA
>NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein
MAIPYLEDVFKISGVPSYTFVRPSEFNRLKVALRTPGRGVVVEGPSGIGKSTAATKVLEELGLDGSVVKLSARVPADIEYIEMLPELGDFGTVIVDDFHRLTDSTKARIADLLKVTADMEHTRRKLVVIGINDAGRALIKSAPDLSNRIDIIRFEVEPASKIEELVSAGETALNVQLDARDLIIEKARGSFYLAQLLCWDACVQAEVTEKAQNRQSISTSYAAIQRRVVERQKERFGPAVRSFARGTKFRPSGRAPYLHILKWLSESESWSISIQDEMRKHPNEKASVGVVLEQGYLAKLTEKSDIAEILHFDPDSKVLAVENPLLIFYLRNISWPQFVRDVGFTKIDYKENYDFALSFAGEDRAYAENLRNRLEDNGHSVFYDFAEQHRFLGQDIETYMGPIYASDSRCVVAVLGEMYGKKRWTLFESSQFENRIEPGEVVPIWSTKVPPTSFDTTRQRGGLEFDPEGDLIQQAAAHAEILSRMIAERT
>NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein
MDLSQAALLVVAGLAAGVMNAVAGGGSLITFPALIAIGLHPVAANVTNSISVSPGYLSSVAGSRQDLPERRRLLPLIPTAVLGALAGSALLLVTPARAFELVVPFLVLGASAALAFQSRLRRLVGHPAELSPRRRAVTVQLMVAAGSVYGGYFGAALGVMLVAGLALVLDETLVRVTAVKNLLSALVGLSTVVVFGLFGPVNWVAVAVLVPATIVGGYAGARLARRLAPAVLKAVIVIFGTGIGLLLLYRALR
>NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter
MWKDHLTEIIVFSLLFLLVSAMGFVAARWRAPNDMAHLDEWGLGGRSFGGWITWFLVGGDLYTAYTFVAVPALMFGAGAAGFFAVPYTIIIYPLVFLVLVRLWSVSHRHGFVTPADFVRTRFGSPTLALLVAITGIVATMPYIALQLVGIEAVLKTMGVTGDNAIARHLPIILAFAILAAYTYQSGLRAPALIAFVKDSLIYIVILVAILWLPHKLGGWSSIFDAADAKFKATPSPADGIVLNANNQVQYITLAFGSALALFLYPHSLTGVLASKNRDVIKRNMSALPAYSLLLGLIALLGFMAIAAGVKPLPGAKPGTADSNTVVPLLFDMQFPDWFAGVAYAAIGIGALVPAAIMSIAAANLFTRNIYKEYLKRDATAAQEATVAKIASLVVKVGAVACIVFLDPQFSIDLQLIGGIIILQTLPAVALGIYTRWFHRGGLIAGWVAGMGMGMWMLYQIGNPTTGKKHFAGSAFPLSEFGFDTKKTIYVGIVAVLVNLLVAVLVTLALRAGRVADGPDGTTHDDYFADEGDPRVTPGGREDAEAAPEPVA
>NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein
MGESVAGEPPRPADPDTAGSGPLGGDPAQTALSEAKDRSPWNWLLFVPIVVPLITPLFNRDAPRLLGFPTFYWLQLAFIVLGVATTTVVYQMTKKRR
>NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase
MAVDRVVVEADGGARGNPGPAGYGAVVRDDRDGQVLIERSDAIGVATNNVAEYRGLIAGLEAAAELGASRVAVRMDSKLVVEQMCGRWQIRNQGLRPLAARAAALVSRFAAVDFEWVPRDRNRHADALANAAMDQAASGSAGSAGSAGSRTNGSAANGSAAEADPGPRAGAPVSWEPRPSSTATRLLLVRHGETEFTARRRYSGRGDVPLTDLGRRQAAAVAGRVAGLCAQVAAVVSSPLGRCTATARSIAAATGDPPLVIRDDLIECDFGEWEGRTFAEVHERWPAEQADWLGSPAVAPPGGESFVEVATRVRRAVADLVAAYPKATIAVVSHVSPIKLILRDALAAGDSFLHRLYLDAAGLSVVDYWPDGGVAVRSVNEVAHLAD

Crispr_ID: NZ_CP022961_26

• CRISPR_ID: NZ_CP022961_26
• CRISPR_location: 4922174-4922431
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP022961_26

Consensus_repeat	Method
CTTGCGGGCCGGCGCCTTCTTGGC	CRISPRCasFinder

spacers of NZ_CP022961_26

>26.1|4922198|24|NZ_CP022961|CRISPRCasFinder
GGTCGCCGCCTTGCGGGCCGGCGC
>26.2|4922246|39|NZ_CP022961|CRISPRCasFinder
GGTCGCCGTCTTGCGGGCCGGCGCCTTCTTCGCCGCCGT
>26.3|4922309|21|NZ_CP022961|CRISPRCasFinder
CGTCGTCCGCGTGGTCGTGGT
>26.4|4922354|54|NZ_CP022961|CRISPRCasFinder
CGCCGCCGTCTTCTTCGCGGTCGTCTTCCTGGCTGTCGCCCGCGTGGTCGTCGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_26

CRISPR arrays

The CRISPR arrays of NZ_CP022961_26

>merge|NZ_CP022961|26|4922174-4922431|CRISPRCasFinder
CTTCCTCGCCGGCGCCTTCTTGGCGGTCGCCGCCTTGCGGGCCGGCGCCTTGCGGGCCGGCGCCTTCTTGGCGGTCGCCGTCTTGCGGGCCGGCGCCTTCTTCGCCGCCGTCTTGCGGGCCGGTGCCTTCTTGGCCGTCGTCCGCGTGGTCGTGGTCTTGCGGGCCGGTGCCTTCTTGGCCGCCGCCGTCTTCTTCGCGGTCGTCTTCCTGGCTGTCGCCCGCGTGGTCGTCGCCTTCTTCGCCGGCGCCTTCTTGGC

>NZ_CP022961|26|27|4922174-4922431|CRISPRCasFinder
CTTCCTCGCCGGCGCCTTCTTGGC	GGTCGCCGCCTTGCGGGCCGGCGC
CTTGCGGGCCGGCGCCTTCTTGGC	GGTCGCCGTCTTGCGGGCCGGCGCCTTCTTCGCCGCCGT
CTTGCGGGCCGGTGCCTTCTTGGC	CGTCGTCCGCGTGGTCGTGGT
CTTGCGGGCCGGTGCCTTCTTGGC	CGCCGCCGTCTTCTTCGCGGTCGTCTTCCTGGCTGTCGCCCGCGTGGTCGTCGC
CTTCTTCGCCGGCGCCTTCTTGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|273198
NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter	unknown	unknown	gnl|CDD|223664
NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240032
NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP022961.1|WP_095566271.1|4922665_4922896_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase	unknown	unknown	gnl|CDD|132882
NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein	unknown	unknown	gnl|CDD|227922
NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase	unknown	unknown	gnl|CDD|273873
NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320687
NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234723
NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238564
NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|223252
NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein	unknown	unknown	gnl|CDD|371707
NZ_CP022961.1|WP_095566274.1|4925057_4925270_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein	unknown	unknown	gnl|CDD|379389
NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|227253
NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase	unknown	unknown	gnl|CDD|237577
NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein	unknown	unknown	gnl|CDD|377640
NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase	unknown	unknown	gnl|CDD|180903

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase	gnl|CDD|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter	gnl|CDD|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	1.64396e-57
NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein	gnl|CDD|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.40671e-49
NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.71949e-36
NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase	gnl|CDD|273873	TIGR01915, F420-dependent_NADP_reductase, NADPH-dependent F420 reductase. This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport].	7.26063e-71
NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase	gnl|CDD|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	3.50851e-114
NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	9.46981e-09
NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein	gnl|CDD|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	3.86619e-08
NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease	gnl|CDD|320687	cd07328, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase. This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.	7.09683e-27
NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl|CDD|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	2.62054e-156
NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.37919e-19
NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein	gnl|CDD|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.71203e-49
NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase	gnl|CDD|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein	gnl|CDD|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	9.63843e-92
NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein	gnl|CDD|227253	COG4916, COG4916, Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown].	1.21667e-11
NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase	gnl|CDD|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein	gnl|CDD|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	2.93825e-10
NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase	gnl|CDD|180903	PRK07238, PRK07238, bifunctional RNase H/acid phosphatase; Provisional.	1.42359e-167

Protein sequences

>NZ_CP022961.1|WP_095568010.1|4919281_4919980_-|NADPH-dependent-F420-reductase
MAYDASSFPDVTGLTLAIIGGTGDQGRGLAYRFVRAGQRVLIGSRSAERAGQAAAEIAALPGLPAGTEVAGMANADAAAGADVVIIAVPWDGHGDTVAQLREPLAGKIVIDCVNPLGFDKHGPYPLPVPEGSAVQQAAALLPESRVCAAFNHVSAPLLADPEVDRIDLDVLICTEDREVAGVVAALAARIEGMRGIYAGRLRNAHQIEAFTANLIAINRRYKTHAGIRVTDL
>NZ_CP022961.1|WP_095568009.1|4918506_4919244_-|ABC-transporter-substrate-binding-protein
MPAPPRRVVSLVPSLTEAIAVTAPELLAGATDYCTHPAGLDVPRVGGTKYPDLERILAADPDLVVANAEENRREDVEALRAAGVPVWVTFPRTLDAALVSLDRLLAALGRTTGPPWLAAARAAWAAPPVPAGRRRAVVPVWRRPWVVLGSGTFAGDLLARLGVRNCYADAAQRYPRPALSELLDQRPELVVLPDEPYPFSDRDGPEAFAGIPAALLSGRHLTWYGPSLAEAPALLAAQLAAANPR
>NZ_CP022961.1|WP_095566268.1|4917596_4918442_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MVESTPAEVTALYGGPATRRVRTRDLLAAKERGERWPMLTAYDQYTAAIFDQAGIPVLLVGDSAANNVFGYETTVPVTAEELLPLVRAVVRSTRHTLVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEGGRRCAAQIAAISGAGIPVMAHVGFTPQREHAIGGYRVQGRGDAAEEVIADARAVAEAGAFAVVLEMVPGEVAKRITAQLPIPTVGIGAGPDTDAQVLVWQDMAGLRSGRMPRFVKRYADLAGALTEATRQFASEVRDGQFPAAEHTF
>NZ_CP022961.1|WP_095566267.1|4915631_4917416_+|NAD+-synthase
MPTLRLALAQVNPTVGDLAGNADIVRRSARDAADAGAHLVAFPELMLTGYPVEDLVFRSSFVRASQHALRELAAGLATDGLGELPVLVGYLDADGPPATRADAIPDHGARNAMALLHGGQIRATYFKHHLPNYGVFDEDRYFVPGQTLTVVRVGGVDVALTICEDMWQAGGPFAVARRADVGLVVTINGSPYELNKDDVRLPLVRRRAAEAGATIAYVNMVGAQDELVYDGDSMIVAADGTLLARAPQFVEHLLVHDVQLPAAGTGDTPPGSPPGSPAGGPAEMDVRRITLSDAVPAPAGPSASGEISEPVPDEAEVWNALVLGLRDYVDKNRFPSVILALSGGIDSALVATLAVDALGPDRVVAVSMPSRHSSEHSKTDAADLAKRTGLDFRTEPIQPMVDTFLANVSLSGLAVENLQARVRGVLLMALSNQEGHLVLTTGNKSELAVGYSTLYGDSVGGFNPIKDVWKTLVWKLARWRNEEAVRRGETPPIPENSIVKPPSAELSPGQLDTDTLPDYSMLDGILTGYVDGDAGRDDLIAAGHDADLVDRVLRMVDIAEYKRRQSAPGTKISIKAFGRDRRLPITNRWREHGV
>NZ_CP022961.1|WP_095568008.1|4914042_4915392_-|type-I-glutamate--ammonia-ligase
MDRQQEFVLRTLEERDIRFVRLWFTDVLGTLKSVSVAPAELEAAFDEGIGFDGSAIEGFARVFESDMIAMPDPTTFQVFPFEGGVSGESARMFCDILLPDGSPSWADPRHVLRRALSRAAEKGFTFYTHPEIEFFLLEDGIADGSVPVPVDTGGYFEHTTHAVARDFRRQAVLALERIGISVEFSHHEVAPGQQEIDLRYADALATADNIMTFRHVVKEVALSTGVHASFMPKPFTDQPGNGMHTHLSLFEGERNAFHDAGDPMKLSKVARAFIAGLLRHAREYTAVTNQWVNSYKRLFPLTLPDRITESPAYVCWGHLNRSALVRVPAYGKPTSARVEVRSIDSATNPYLAFAVLLGAGLKGIEEGYDLPPGAEDDVWSLSNAERKAMGYEALPENLAEAIDVMAGSELVAEVLGEHVFDYFLRNKRAEWEEYRREVTPYERRRYLSL
>NZ_CP022961.1|WP_095566266.1|4910664_4913964_-|hypothetical-protein
MSDTLSYADAVRLLGGGENRWVDLIDRMAGGAVLSAAIPVPGLADANVGLVGLGRELLRAVAERRSGLSRYDRTRRLEAAHAVIAVTAYFEALAEVGPPDLLSELDVVRSEQLALAGARPTDPRSTLEAMFALPVPVPGPALPYPRLRGELRTFYTELAGRLTLFTADLREGTAPPWHAIDPLNRAIELGLDRHRELLTRLAGDFPEVGFWIGLHEQEATRAEVRALGTGLAELRAELDRISTGAGPDARRAALATAYTAELDRPIAASGDVPAGLRLPTLGGAYVPPLFRVAELGVAARPAEEEWWADRPLRGDLAEFLVGQLTSPGAVRAPLLVLGQPGSGKSVLTKILAARLPAADFLAVRVVLRDVPAAADLQEQLEHAIRDATGDRPDWPALASAAGDALPVVLLDGFDELLQATGVSQTDYLTRVAEFQRRESVQGRPVAVLVTSRTSVADRARPPAGALALRLEPFDPARVQRWLDTWNETNAGLPGFTPLPAEVALRHRELAEQPLLLLMLALYDAGGGDLRAAGDLRHAELYERLLDNFARREVVKQRELTGRELDRAVEDELRRLSVVAFAMFNRRAQWSTEDALEADLAALPFDGAAVVARDDRRTPLRAAEIVLGRFFFVHRSQASRDADRPIAYEFLHATFGEYLVARLTWQVVENLVAVDRAASLAPGGPRVDDDLLYALLSHAVLTSRAPVVGFLAERLSILDDELRAGWADLLVRLFRTVNHRTGPRALDGYRPLPLPVPARYAAYAANLLVLAVCAAGEITGSRLYPEADDPVPDWHAQALLWRSQLHPEEWSSLVAALELGRRADGQVRDVALRLDSGAAAPPIDLTWTYSWPGDGELLELASSKASGQPAAVLRRKTYFECGINGDVLQHALDPLVEAAPWALTRYVSTIGRGAETAHSVAWILLAAMLGPVTGQPLVELRSVRQYLDLGLDDAADDPSGSEAPEQSRLRLLGLLLDRLSADASGPVAVAVDLLDQAVPLLNPVHDLAEPVLRCCLAFLGRGDRNEDRAIADVVARAIGQAGQSRLWTGELALEARVRLHELGVRTLPIAPQHVEALTALHQRRRPDLLVRMRPLIQPAD
>NZ_CP022961.1|WP_095568007.1|4908820_4909696_+|LD-carboxypeptidase
MLVSPSGPTRPERVARGVELLTGWGLRPLLAPHAYARHGYLAGTDELRAADLNTAFADPEIRGVLCTRGGYGAQRVVDAIDMAAVRRDPKVVAGFSDITALQFALWRGARLASVHGPGAAWLDERTPLTSAESLHAALMSTEPVSVVRSAEEETARLVVPGVATGPLLGGNLCLITASLGTPDMPDLTGAILLIEEVEEQPYKVDRMLTHLRRAGALDGVAGVAVGQFTRCADDWPVTVVDVLAERLGDLGVPVLGGLPVGHGVGQLTVPVGTPATLDAVTGTLTVTAAVR
>NZ_CP022961.1|WP_095566265.1|4903227_4904652_+|type-I-glutamate--ammonia-ligase
MFANPEELLRYLKNEDVKFVDVRFCDLPGVMQHFNLPVESFDESIFETGLAFDGSSIRGFQAIHESDMLLLPDVATAFVDPFRTQKTVALNFFIHDPFTREAYSRDPRNVAKKAEAYLAASGIADTAYFGPEAEFYIFDSIRHETSAHQAYYYIDSVEGAWTSGREEEGGNRGYKTAYKGGYFPVPPVDHYADLRDQIVRKLVDTGFTVERSHHEVGTAGQAEINYKFSTLLHAGDQLQLFKYIVKNTAWAAGKTATFMPKPLFGDNGSGMHTHQSLWMNGEPLFYDETGYGGLSDTARWYIGGLLHHAPSLLAFTNPTVNSYRRLVPGFEAPVNLVYSQRNRSACTRIPVTGSNAKAKRVEFRVPDPSANVYLAFSAMMMAGLDGIRSKIEPPQPIDKDLYDLPPEEWGSVKQVPGSLPEVLDALEADHDYLLDGGVFTPDLISTWVDYKRANEVDPVRLRPTPHEFEMYYNV
>NZ_CP022961.1|WP_095566264.1|4902596_4903169_-|hypothetical-protein
MAGRLPGRITYVSVVLRPRSTIPPACGYGVDAGLCAVRLPWLAVTRQQDGEPVTHGTDPAGTDRADPAPGIEPASLGRRFGALIIDWVLCLLVGSMIADPVRAGWPPVLVLILEYGFFLGLFAQTPGMFLTRIACVSHRDGGRIGIPRALLRGLLLALLVPALIMDDQRRGLHDRWSGSIVIPVTPRSAG
>NZ_CP022961.1|WP_095566263.1|4901872_4902562_+|DUF4191-family-protein
MATPQEKVSFGQRLKQIGMVFSFTAKQDRLFIPLVVVAVLVPLALTVVVAIVWGWMWVPVGVLLALLAVLIVLNLRSNRAMMSAAEGQRGAAAQIVENMRGDWRVTPAVSATTQMDMVHLVIGKPGVVLLAEGNPQRVRGLLGQEKRRLSKVIGSAPLYDYLIGSGENELPIRKLRTTLMRLPRNLSGKDVNALDKRLKALSARPQMPKGAIPKNMRPPRGAFRQTRGR
>NZ_CP022961.1|WP_095566271.1|4922665_4922896_-|hypothetical-protein
MRDAVHSIPMSDSGRGAQYFWCTRHHRVETEADVCPARYVLGPYASAADAANALEQVRERNEAWDAEDVRWAGEER
>NZ_CP022961.1|WP_095566272.1|4923095_4924388_+|M48-family-metalloprotease
MVGKTSAAAASTPAACARCARPTVSLGSATPWCGHCEWNLDRYDEASTDPEFGWVWVDRRLRGIAYRLSRRQYAELAAAAGGRSRYGAARIVLVVASVLLLGAFAALVAASCWLLWRYPLLSLYTVLAALGLATAVLMRPRLGRLHPLARVVDADRAPELHRLIREVADVVGVPPPHVVAVDESFSAYTSAVGPRRRRVLCLGLPLWAALAPQERVALLGHELGHFANGDIRRGLLTQPAFTMLGHAAQILSPVSTHNPGGGLIGLLTDLVSRVVLWTLSRLVLAGHLLLLWVGLRDGQRAEYRADELASVAAGSTAAVGLMDTLVGMDVVQMMVCREARAGLGPADWRAVVANTRVESAAQLPLRRQLSIRRDVSLFASHPPSGLRARLVEARPHRDPRIVLTEDRAARIDAELAAEFAAVRRELAVVG
>NZ_CP022961.1|WP_095566273.1|4924547_4925018_+|NUDIX-domain-containing-protein
MAIPDYIVRMRKHVGTDLLWLPSVSAVVLNEHGELLLGRRADDGRWSVISGFVEPHEQPAQAVVREVEEETGVLVAPERVSSVWAHPHRYPNGDHCQYLNIGYRCRKLGGEARVNDDESTDVRWVPLDRLPDLDEHARLTIEHALADQPAAWFADN
>NZ_CP022961.1|WP_095566274.1|4925057_4925270_+|hypothetical-protein
MSGVSTLFIGGPADGVRQDLPADPDGRPPARWVLRGHDAPGDHLYERAGPDPRGGWTMHHVRTDPAGMSE
>NZ_CP022961.1|WP_095566275.1|4925345_4926575_-|SpoIIE-family-protein-phosphatase
MARAEVFTDEQRLRRIEAVTDATLSRLDVADLFDELLDRVRDLLRVDTAVILLLDARAQQLVATAARGLEEEVRQGFRLSVGRGFAGRVALTRRPLIIPNVTASDVVNPILLEAGIRSLLGVPIIARGDLIGVLHVGTLRPRRFTPDDVRLLELVADRISLASRARASSLDQAAALALQRSLIPTELPDVPGLELAARYVPGHACGVGGDWYDVFTLPSGWHGVVVGDVSGHGLQSAVVMGRVRSALRAYALVCDDPAEALTLLDRKVVHFEAGSLTTALYAMISPDGATLRISLAGHPRPVLALPGRPNGLLAGHIDPPLGIGRQHPCRHTTTVDFPPGAVLVSYTDGLVERRGEVFDDGVDRLLAAIPLAPAETVTATVMATLDTEHPADDIALLAIRRLPERHGTA
>NZ_CP022961.1|WP_157756879.1|4928663_4930136_+|TIR-domain-containing-protein
MAIPYLEDVFKISGVPSYTFVRPSEFNRLKVALRTPGRGVVVEGPSGIGKSTAATKVLEELGLDGSVVKLSARVPADIEYIEMLPELGDFGTVIVDDFHRLTDSTKARIADLLKVTADMEHTRRKLVVIGINDAGRALIKSAPDLSNRIDIIRFEVEPASKIEELVSAGETALNVQLDARDLIIEKARGSFYLAQLLCWDACVQAEVTEKAQNRQSISTSYAAIQRRVVERQKERFGPAVRSFARGTKFRPSGRAPYLHILKWLSESESWSISIQDEMRKHPNEKASVGVVLEQGYLAKLTEKSDIAEILHFDPDSKVLAVENPLLIFYLRNISWPQFVRDVGFTKIDYKENYDFALSFAGEDRAYAENLRNRLEDNGHSVFYDFAEQHRFLGQDIETYMGPIYASDSRCVVAVLGEMYGKKRWTLFESSQFENRIEPGEVVPIWSTKVPPTSFDTTRQRGGLEFDPEGDLIQQAAAHAEILSRMIAERT
>NZ_CP022961.1|WP_095566277.1|4932693_4933455_+|sulfite-exporter-TauE/SafE-family-protein
MDLSQAALLVVAGLAAGVMNAVAGGGSLITFPALIAIGLHPVAANVTNSISVSPGYLSSVAGSRQDLPERRRLLPLIPTAVLGALAGSALLLVTPARAFELVVPFLVLGASAALAFQSRLRRLVGHPAELSPRRRAVTVQLMVAAGSVYGGYFGAALGVMLVAGLALVLDETLVRVTAVKNLLSALVGLSTVVVFGLFGPVNWVAVAVLVPATIVGGYAGARLARRLAPAVLKAVIVIFGTGIGLLLLYRALR
>NZ_CP022961.1|WP_095568011.1|4933647_4935303_-|sodium:solute-symporter
MWKDHLTEIIVFSLLFLLVSAMGFVAARWRAPNDMAHLDEWGLGGRSFGGWITWFLVGGDLYTAYTFVAVPALMFGAGAAGFFAVPYTIIIYPLVFLVLVRLWSVSHRHGFVTPADFVRTRFGSPTLALLVAITGIVATMPYIALQLVGIEAVLKTMGVTGDNAIARHLPIILAFAILAAYTYQSGLRAPALIAFVKDSLIYIVILVAILWLPHKLGGWSSIFDAADAKFKATPSPADGIVLNANNQVQYITLAFGSALALFLYPHSLTGVLASKNRDVIKRNMSALPAYSLLLGLIALLGFMAIAAGVKPLPGAKPGTADSNTVVPLLFDMQFPDWFAGVAYAAIGIGALVPAAIMSIAAANLFTRNIYKEYLKRDATAAQEATVAKIASLVVKVGAVACIVFLDPQFSIDLQLIGGIIILQTLPAVALGIYTRWFHRGGLIAGWVAGMGMGMWMLYQIGNPTTGKKHFAGSAFPLSEFGFDTKKTIYVGIVAVLVNLLVAVLVTLALRAGRVADGPDGTTHDDYFADEGDPRVTPGGREDAEAAPEPVA
>NZ_CP022961.1|WP_095566278.1|4935308_4935602_-|DUF3311-domain-containing-protein
MGESVAGEPPRPADPDTAGSGPLGGDPAQTALSEAKDRSPWNWLLFVPIVVPLITPLFNRDAPRLLGFPTFYWLQLAFIVLGVATTTVVYQMTKKRR
>NZ_CP022961.1|WP_095566279.1|4935755_4936919_-|bifunctional-RNase-H/acid-phosphatase
MAVDRVVVEADGGARGNPGPAGYGAVVRDDRDGQVLIERSDAIGVATNNVAEYRGLIAGLEAAAELGASRVAVRMDSKLVVEQMCGRWQIRNQGLRPLAARAAALVSRFAAVDFEWVPRDRNRHADALANAAMDQAASGSAGSAGSAGSRTNGSAANGSAAEADPGPRAGAPVSWEPRPSSTATRLLLVRHGETEFTARRRYSGRGDVPLTDLGRRQAAAVAGRVAGLCAQVAAVVSSPLGRCTATARSIAAATGDPPLVIRDDLIECDFGEWEGRTFAEVHERWPAEQADWLGSPAVAPPGGESFVEVATRVRRAVADLVAAYPKATIAVVSHVSPIKLILRDALAAGDSFLHRLYLDAAGLSVVDYWPDGGVAVRSVNEVAHLAD

Crispr_ID: NZ_CP022961_27

• CRISPR_ID: NZ_CP022961_27
• CRISPR_location: 5008540-5008625
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_27

Consensus_repeat	Method
GGTCCGGGGCGGGCACGGGGGTCCGGGG	CRISPRCasFinder

spacers of NZ_CP022961_27

>27.1|5008568|30|NZ_CP022961|CRISPRCasFinder
ACCGGCACGGCGGTCCGGGGCGGGCACGGC

CRISPR arrays and Neighbor proteins around NZ_CP022961_27

CRISPR arrays

The CRISPR arrays of NZ_CP022961_27

>merge|NZ_CP022961|27|5008540-5008625|CRISPRCasFinder
GGTCCGGGGCGGGCACGGGGGTCCGGGGACCGGCACGGCGGTCCGGGGCGGGCACGGCGGTCCGGGGCGGGCACGGCGGTCCGGGG

>NZ_CP022961|27|28|5008540-5008625|CRISPRCasFinder
GGTCCGGGGCGGGCACGGGGGTCCGGGG	ACCGGCACGGCGGTCCGGGGCGGGCACGGC
GGTCCGGGGCGGGCACGGCGGTCCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095566328.1|5019385_5021596_-|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815
NZ_CP022961.1|WP_095566316.1|4996936_4997851_+|cation-transporter	unknown	unknown	gnl|CDD|224151
NZ_CP022961.1|WP_095566315.1|4994740_4996858_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226482
NZ_CP022961.1|WP_095566329.1|5021781_5022357_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP022961.1|WP_095568020.1|5003203_5005978_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|225461
NZ_CP022961.1|WP_095568021.1|5010114_5010765_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380054
NZ_CP022961.1|WP_157756883.1|5000695_5001253_-|hypothetical-protein	unknown	unknown	gnl|CDD|237057
NZ_CP022961.1|WP_095568023.1|5012772_5014176_-|NADH-quinone-oxidoreductase-subunit-I	unknown	unknown	gnl|CDD|131014
NZ_CP022961.1|WP_095566324.1|5008741_5010208_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|236199
NZ_CP022961.1|WP_095566318.1|4999299_4999680_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP022961.1|WP_157756886.1|5017328_5017748_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566323.1|5007388_5008516_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133382
NZ_CP022961.1|WP_095566325.1|5012045_5012714_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP022961.1|WP_095566319.1|5000189_5000615_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_157757020.1|5018355_5018946_+|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|238038
NZ_CP022961.1|WP_095566322.1|5002534_5003089_+|thioredoxin-domain-containing-protein	unknown	unknown	gnl|CDD|372611
NZ_CP022961.1|WP_095566317.1|4998129_4999176_+|hypothetical-protein	unknown	unknown	gnl|CDD|227278
NZ_CP022961.1|WP_157756884.1|5010873_5011869_+|L-glyceraldehyde-3-phosphate-reductase	unknown	unknown	gnl|CDD|381377
NZ_CP022961.1|WP_157756885.1|5014153_5015953_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP022961.1|WP_095566321.1|5001782_5002457_+|BON-domain-containing-protein	unknown	unknown	gnl|CDD|225379

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095566328.1|5019385_5021596_-|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	2.52154e-124
NZ_CP022961.1|WP_095566316.1|4996936_4997851_+|cation-transporter	gnl|CDD|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	2.20144e-94
NZ_CP022961.1|WP_095566315.1|4994740_4996858_+|AAA-family-ATPase	gnl|CDD|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	3.677e-62
NZ_CP022961.1|WP_095568020.1|5003203_5005978_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	5.6977e-81
NZ_CP022961.1|WP_095568021.1|5010114_5010765_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	1.79825e-27
NZ_CP022961.1|WP_157756883.1|5000695_5001253_-|hypothetical-protein	gnl|CDD|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	8.40626e-06
NZ_CP022961.1|WP_095568023.1|5012772_5014176_-|NADH-quinone-oxidoreductase-subunit-I	gnl|CDD|131014	TIGR01959, NADH-quinone_oxidoreductase_subunit_F, NADH-quinone oxidoreductase, F subunit. This model describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, where the quinone may be plastoquinone and NADH may be replaced by NADPH, nor in Methanosarcina, where NADH is replaced by F420H2. [Energy metabolism, Electron transport].	3.49344e-39
NZ_CP022961.1|WP_095566324.1|5008741_5010208_+|FAD-dependent-oxidoreductase	gnl|CDD|236199	PRK08244, PRK08244, monooxygenase.	3.99988e-124
NZ_CP022961.1|WP_095566318.1|4999299_4999680_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.93933e-17
NZ_CP022961.1|WP_095566329.1|5021781_5022357_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.19364e-11
NZ_CP022961.1|WP_095566323.1|5007388_5008516_+|MerR-family-transcriptional-regulator	gnl|CDD|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	2.49239e-31
NZ_CP022961.1|WP_095566325.1|5012045_5012714_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.85393e-51
NZ_CP022961.1|WP_157756885.1|5014153_5015953_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	2.11706e-08
NZ_CP022961.1|WP_157757020.1|5018355_5018946_+|DUF222-domain-containing-protein	gnl|CDD|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	2.62652e-10
NZ_CP022961.1|WP_095566322.1|5002534_5003089_+|thioredoxin-domain-containing-protein	gnl|CDD|372611	pfam13462, Thioredoxin_4, Thioredoxin.	4.3203e-23
NZ_CP022961.1|WP_095566317.1|4998129_4999176_+|hypothetical-protein	gnl|CDD|227278	COG4942, COG4942, Membrane-bound metallopeptidase [Cell division and chromosome partitioning].	1.36289e-06
NZ_CP022961.1|WP_157756884.1|5010873_5011869_+|L-glyceraldehyde-3-phosphate-reductase	gnl|CDD|381377	cd19151, AKR_AKR14A2, Salmonella enterica aldo-keto reductase (AKR) and similar protein. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).	0
NZ_CP022961.1|WP_095566321.1|5001782_5002457_+|BON-domain-containing-protein	gnl|CDD|225379	COG2823, OsmY, Predicted periplasmic or secreted lipoprotein [General function prediction only].	2.82558e-22

Protein sequences

>NZ_CP022961.1|WP_095566323.1|5007388_5008516_+|MerR-family-transcriptional-regulator
MHSIGELSRASGLSVSALRFYDGAGVLVPAVVDPHTGYRWYARRQLGPARLLAGLRRVGMPLPEIRTVLARWPDPDAVVPLLDAHLRRLQDGLADARLELSRVHALLIREENPMSTRCTVRASTLAAALDAVRFAVGTDPELPALSGVRLEETDDGLRLLATDRYRLAIATAPVLGRSGPPIRVTLPAALVDEVRDRLGGRTDGRLGGRTGDRTGGRSPAPEDETDDEVVVEVADAELSVTVAGHRATGGAVAGEWPDLTRVLRDASPGPHRRLAVDGTALRAAVRSGRALVREHDGVPREIVVLAPDPAGGVAVSDPHAPGPGETIALDREFLLQALDAGGPGQLVLELDNPVRPLAIRSATGPGYSVLMPVRL
>NZ_CP022961.1|WP_095568020.1|5003203_5005978_-|helix-turn-helix-transcriptional-regulator
MSQDLPTVTAPPPLPAGRLDPAPVPDTLVERPRLHQLLDTGAARPVTLVRAPAGWGKTVLLSAWYRAGRWPGRPVWLTLEPADSADRVCAYLATALEAGPAGAGDPLDRLAGAVARHGEPVVLVLDDADHAGPDLWDGLDRLARHCAGRLRLVLAARTDPALGLHRWRLSGELTELGVAELAFTPQEADRLLAAHGLRLPADRVADLVERAEGWPAGLRLAALALRDRVDPDGYAAGFDGDDPGVADYLRSEVLAGLPAADRDALRRAAVAACLSADLLVALDGPDAEDLLDRAERTGFVLPLGTRPPTWRCHRLLAGLLRSELARLPGSEVRELHRRAADWAAGHDRPADALRHALTADAPALARRILRDHWPDLIPAVATGDPGVPAPPPPEDLGVEPELALAYAADRLRERDPAAVVATLGLIAGRAGAAVRPGAAGRDGAHELPVPVVLAALRLGAAQLAGDPAGVAEEARALLDAAGIAPAGPAGVLPAGSAVPAGPVGPAVLDAAAHGGAHGGPDPAASARALGGTALGAVRFGEGDLAGAEADLAAARTDARRAGLDRAELVATARLALVRAVRGPLRAAEQDARTAVGSTACRDRRTAADCGPAYLAQAVVAAERDRPAEAAAHLALADGARQPGDEPVLAALAELVRARLRAVDGDPVGAFQALQRGREHLAGRPAPLVEPALLAAEADLRSANGDLDTARSLLVGAIEVAGEPAPPLAVALARVHLLAGDPGAAARTLPDWEAPAAAGWPMPVRLAAGLLAALAARAGDGHTGGGRPASGGRAGRIVERVLDLAEPDGYRLVFTHSNPPVRELLAEQRDAGTAHWPMLDELLRGDGHAPAAGPPAAPAALGEPLTERELTVLRYLQSILSNVEIASEMSLSVNTVKTHVRNIYRKLDANRRREAVRRARELHLL
>NZ_CP022961.1|WP_095566322.1|5002534_5003089_+|thioredoxin-domain-containing-protein
MSSTPLQVTTGRLRTPVHENDHARGPVDAAVTVVQYADFQCPHSGAAARNLRDVLRQRADTVRLVYRHFPVVNVHPYAEMAAETAEAAGSRDRFWEVHDWLFDHQEQLDPVHLSLGAQQAGVPVDAVSDEVNAHRWLDRVRADFVGGIRAGVNATPTFFVNGARHEGGYALADLLTAVDAAAGP
>NZ_CP022961.1|WP_095566321.1|5001782_5002457_+|BON-domain-containing-protein
MVTTMARNDEAIQRNILAELDWDPQVRPNEIGVTVSDGVVALTGWVDSYARKWAAERAAHRLSGVRAVANDIAVRLSTATGRTDAEIATSVTRALEWDAFIPADGLSVTVANGWVVLRGEVEWEYQRRAAERSVRRLTGVQGLTNGIQVRPRVRPSAEELRHRLVTALVRTVSADAQQLGIEVDDGTVTLRGTVRSALERQEAERVAWSGPGVEEVRNELVVQG
>NZ_CP022961.1|WP_157756883.1|5000695_5001253_-|hypothetical-protein
MDRQATGLFAGIVVVGLGPALWVGAQLSRPLGPEPNRPRVTVTRPVTYPPTVPAAGFPSPTPPSGPDDQGVSGADPPGQGGGRPVPDQPEVLAGTSAPSGTAASTPGPIGASSARASPSGTAATTQPAGASDPSTDPAQSGSAEPVPTRTAPTQDPDGGESSPPVSPSVHSDEPADPSSGAERPG
>NZ_CP022961.1|WP_095566319.1|5000189_5000615_+|hypothetical-protein
MFGSNLLDRRSRTERIADQAWDHLVAAVNSAGETIRDTALDTARSARSATAGLTDDARDRAGSVADEAWQRASLAFDALSGRRSRLPWTYLIAAGLIGAAVGWAAGTAARAAMARDNATLGAGDEVEFVDVDRPGSPASNN
>NZ_CP022961.1|WP_095566318.1|4999299_4999680_-|STAS-domain-containing-protein
MSLSISTSILPGGIVEISPVGEIDVDTAFEVREAVAGVLAKGRPSRIELNMRRVGFIDSVGISAMVGGFQMAEVSGVKLAVTEPSRFVHRQLWVTGLLGLFGAPEPHFSGAPEARACTAADQGQRG
>NZ_CP022961.1|WP_095566317.1|4998129_4999176_+|hypothetical-protein
MAPARRTAAVLAAFLGAALSFAAPTSPAAAGTGPVAGLLAEPSGTDDEGGSDTLRQQLDAASRGYLDAKTKLANSTKRQKDLAGHLDSLGDEVRMRTQTVGNLADAAYRTGRLGPMAALLNAGSPDGFIDAAARLQAVASNEDRQLRALLDTRDQESLAKEAIDKEVAEQRTQVAVMAKRKQQAERALAASGGGGSTSGTGGTSSATAKPAPRNADGSWPAESCSVNDPTTSGCITPRTLHAMNEAKAAGFTHYISCFRSGGSGEHPKGRACDFAAAKNGFEGVASGADKTYGNNLAAYFIKNADRLGVLYVIWFKQIWLPSSGWKAYSGGNGDPASDHTNHVHLSEY
>NZ_CP022961.1|WP_095566316.1|4996936_4997851_+|cation-transporter
MGAGHDHGGQLQRAADRHRGRLWAALGVLVTLMVVEAGAALFTGSLALLSDAGHMFTDVLGIGMALAAITAARRSDDDPQRTFGLYRLEVLAALANAVLLSGVALYVLAESARRFTDPSPVLAGPMLAVATLGLVANLVAFALLRSAARESINMRGAYVEVLGDLLGSLGVIVAAGTIEVTGWWWADPVVAVGIGLFILPRTWRLGRAALRILVQAAPEHLDVPAVRARLCRVPGVADVHDLHVWTLTSGMEVASAHLAVRPGTEVGDVLTAARSALHEEFRIDHATLQVEPDARPDGCGSTDW
>NZ_CP022961.1|WP_095566315.1|4994740_4996858_+|AAA-family-ATPase
MTDRTILEQEIAAEQRHLDLVYARLEQLRRSAVRAERDGYRLARVGNFGALVERDAMVFHAARRRHLLDAEHEGLVFGRLDLRDSSVLHVGRLGVRGERAEPLVVDWRAPAAAAFYRATAADPQGVVRRRMISSAGERVTRIEDDLLDPEAAPPDLRVVGDGALLANLSRTTGTGMRDIVATIQREQDEAIRSPASGVTLVSGGPGTGKTAVALHRAAYLLYSDRSRFAGGGVLVVGPSGVFVNYISAVLPSLGEDAATLHSLGSLVVGLTATRTEPVPVATVKGSLRMRRVLERAARDAVPGGPRELRLLYRGQLLRLGPAELDRIRERALPRGARRNEVRRAGIDGLFEALWAQALELRIGNLPEQREFEDELAERTDFRDFIRAWWPRLHPRHVLAWLADPLRLRGYAAGVLSAAEIELLIESYRPLRDEGPSIPDVALLDELDELMGRPPRPARRRRDPFLVAGGVREVSTYADRERAARAEAVRRDEDYREYAHVVVDEAQDVSPMQWRMLGRRGRLASWTVVGDPAQTAWTGDPAELARARDRALGRLPRHEFTLSTNYRNSAEIFAVAAGVIRELDPDLPLPRAVRSTGVPPTERTARPAELPAVTAEAAGKLLAEVEGTVGVITPVPRRDEVRGWLGDLVGPRLQVVDALQAKGMEYDGVVLVAPGQIRADSPAGIRTLYVALSRATQRLTVIDTAS
>NZ_CP022961.1|WP_095566324.1|5008741_5010208_+|FAD-dependent-oxidoreductase
MNVDAEVIVAGAGPTGLLLAGDLAAAGVSCTVLERWAHESNLTRAFAVHARTLELFDARGLAEELLGTGQRLRRLRLFGRAQLDLGRLPSRFPFVLVTPQYHTEAVLSRWATKQGARIETGVEVTGVDQDQDAVRVTVGSPAGPRTLRARYLVGADGVRSTVRTALGIDFPGNAAVRSLMLADVRLAEQPPEVLSVGADGRAFAFLAPFGDGWYRVIAWDRTHQLPDSAPVELAEIAALTREALGTDFGMHDARWLSRFHSDERQATTYRSGRVMLAGDAAHVHSPAGGQGMNTGLQDAANLSWKLAAVLHDTAPAALLDTYESERYPVGTQVLRTSGALLRAVTAGPGPRLLLRNLVVRLAAGIPALNDRLAARVSGIATRYPAPPGAHPSVGTRVPDLPLSGPDGTPQRLYEALRGGRSVLVTAAPVTPPPGWAGRLTPAVRADGLPATLLVRPDGYLGWAADGPATPPPASLSAALPGSSSGSLR
>NZ_CP022961.1|WP_095568021.1|5010114_5010765_-|TetR/AcrR-family-transcriptional-regulator
MRAEGSRPVRKSDRTRLAILAAARRQFTDLGYDKASVRSIAGAAGIDPSMVIRYFGSKDGLFDAALAADLALPDLVGVPPADRGRTLAEHFVRRWEGDLHDDALALLLRSAATNPAAADRVREIFRRQLVGMIAAVVPPAEAPRRAGLVATQVLGLALCRYLLRLPPVVGMTPAAIGRMIGPTLQRYLSEPLEEPGSAAERLAGGGVAGPSAAQPR
>NZ_CP022961.1|WP_157756884.1|5010873_5011869_+|L-glyceraldehyde-3-phosphate-reductase
MTYLAAPGRYETMTYRRAGRSGLCLPALSLGLWHNFGHGRSQDQQREILLRAFDLGITHFDLANNYGPPAGSAEERFGRVLATDLGRYRDELVVSTKAGYRMWPGPYGEWGSRKYLLSSLDASLRRLKLDYVDIFYHHRPDPDTPLEETMSALDAAVRSGRAMYAGISNYSAEQTARAAAILRDLGTPLLINQPSYSMLNRWTERDGLLDTLAEVGAGCIAFSPLAQGVLTDRYLDGIPADSRVRTSEFLSERDLDAPTMTVVRELTELAAGQGRTLAQLALVWALRDTRMTSLVIGASSIEQLTANVDALADPKLSPDEIGEIDRILLGG
>NZ_CP022961.1|WP_095566325.1|5012045_5012714_+|response-regulator-transcription-factor
MGRVLVTEDDDRIGQLVGRALRADALTPGSRADGSTGADPALGSEFDLTVLDLTRPGTDGRPVLRRLLAERPGQRVLVLSAAPELGTRIAVLAAGAADFLARPFAVAELVARVRAWMRSAAPGAANRWFQIGPVRLDLLDCLATVNGIDVELALREFLLLQHLMTRAGQPCSRDELLADVWGLTFDPGSNVVDGYVRRLRGKLDRPERIETVRHVGYAYALD
>NZ_CP022961.1|WP_095568023.1|5012772_5014176_-|NADH-quinone-oxidoreductase-subunit-I
MDEFGSLDLAAHEEVHGPIGPLSISSLLRLAEDIQLTGRGGAGFPFARKLRAVLESARSQQSPPVVVVNATEGEPASWKDKVLLTRAPHLILDGAALAAYALDADEIVIGVADDGVGESSLAAALRERQMPVDTGIVTVPHRFISGEGGALVRGINGEAHIPPGRKQRASDSGVGGLPTLLSNAETYAQIAVAARLGPYEYAAVGLEKEPGTVLLTVGGAARRPAVVECPTGTPLAEVLALCDVPPGPGVLVGGYHGKWISAESAAHAEVSRAGLSAVGGTLGAGIILPLGEDTCPLGEVAQVVRYLAGESAGQCGPCRLGLPDLARATDLVVSGANPADTVRTAAGVIKGRGACSHPDGTGRFATSAMEVFAADVVAHTTRDGCGKRVKGVLGLPEAPNVVKRRLAVDWSRCDGHGLCAVVAPEFIRLDDNGFPSFPPTPVPTWLEGGATKAVQMCPALALRLTEE
>NZ_CP022961.1|WP_157756885.1|5014153_5015953_-|hypothetical-protein
MMMLTSAGQVVYAYLFVFTEFYGGVATLVLLSITVMIGLVATDRIVLMIRHRVLMQSAHRALGTLAVGALGLHILTKIAEGHAGLLDPVLPFVSGRGFFVGLGTLAGWAMVAVLWTGLIRMKFAGAGKPWMWRALHSTAYVSWPIALVHGLNAGRTPKSWVTLSYLLCVLLVIAALLVRLSVNLGRKRREAERNPAATRSKGESAGEIEGSRSVRWPVSRGVSDVRVGRDTIGRDTIGRDSVGRDTMVQPERPAASLDSWAPDAGYRAVGSPRRRPGRFTVPQVPAQPGDRPAWQDEPAVATAGGRDRDRDRDRESMADLAEADFEPAGRRYAGAAGARRYEAPEERDIDGRRDIDGRRDADGRRDADGRRGAGERRSSRYAPADMPEEPWDSPRRWAGADATLDAEDLAGSGAARVAPASARPTATTGRRRAATARRPRNASRPPAADPGTAGTTRTRTSARTGTSARTGTTGTAGTSGRIATSATTGTSGRTATSRGRAGTPRWAGRPGTSRRSRTTTRRPWWTSPRGGPCGRPRRAPGAAAGSPPTAGAPPRRRPTAPTGRNCEVRPSDRYGGGRSAGRLFRRTAPDGRAGRVRLA
>NZ_CP022961.1|WP_157756886.1|5017328_5017748_-|hypothetical-protein
MPERVVPEGGVPGRAGPERVVPGRAGGFGSDDAAAAGSQHRGGQLAVARGHHDLRWFAAVLGQLTGTQCEAGQLGQRIVPALARGAIVAGPVRPGQRIEGGQQRRTALGVENTTQPHPAVVAAREGEVTAPLCMFLGAT
>NZ_CP022961.1|WP_157757020.1|5018355_5018946_+|DUF222-domain-containing-protein
MAQAPQAAQAPQAPQAAQAARERLGPRLGTRISAPRATAAVVVAQRPPTPLASRLGPGRLDNGLRLTPETVRRLACDAAILPAVLGGQGQVLDVGRQRRLFTGPLRRALVLRDGGCTFPGCDRPPRWTDGHHIVHWADGGETALANACLLCRYHHRVIHIGEWQVRLAADGHPEFLPPAWIDPDQRPRRNRYHLRR
>NZ_CP022961.1|WP_095566328.1|5019385_5021596_-|penicillin-binding-protein
MPPRSTLSRAATVLLAGVLAGVVLAAVALPANALLGVALKVASDSFSDLPANLRTPPTAQRSYVYANDGKTLITSFYDVNRRDVSLDEIAPVMRQAIVAAEDTRFYQHNGVDPRGLLRAFVANGKGGEVRQGGSTLTMQYVRNVLKTDPSLSAAERAAATEDTVGRKLQEIRYAVALEKKLSKNEILDRYLNIAYFGSGAYGIAAASERYFSKPPAELTLDEAALLAGLVQSPDAYSPISGDRDEALDRRAYVLDAMVGMGNITAAQAAQAEAEPLALEPSDQPNGCTGTPAGHDDWGFFCDYLRAWWLDQPAFGATRAEREAALNRGGYTVVTTLDPEIQATAQHEALSVYGYDNPRAVPMAVVQPGTGRVLAMAVNRHYSLAENPSGQENYPNTVNQLIAGGGTIDGYQAGSTFKLFTMLAALEAGQPLETGFDAPSRLPTGYPDSGPDNCDGSWCPANANPSWMDGYRTMWTGFGRSVNTYFVWLEQRVGADKAVELAQRLGITFRADADADRARNEAAGWGAFTLGVAATTPLDLAGAYATVAAEGTYCTPLPVTSVTGPDGAKLDVGQPDCKRVLDADVARAATDAARCPVGQQSAYGRCDGGTAAQVDGIMDGRPVGGKTGSSEENATETFVAFTPQIAAAGIAANPDDPADHVGSAVQQKVIEAVARTMAAALEGQPVEDFTAPSREMAFGADGPDRLPRSGGPGSGPGPATDPVPGTGADRWSTGRRG
>NZ_CP022961.1|WP_095566329.1|5021781_5022357_+|TetR/AcrR-family-transcriptional-regulator
MAETAATRGQRTRDALCAAAVGLVAEVGWGRVTTRLVAERAGVPVGAVHYHFRSLTDLLIEACAPVLRRVVDEVAAGLGTANDLSSGLDWLVGSLTGYAGDPAALRLPSEIFLAATRDERLGERIDLTIEEFRAVVAGWLERCGHGPDAPAAATVLAAAMDGLLLYRAVGVAIDPTALAGILRRIVTPLPG

Crispr_ID: NZ_CP022961_28

• CRISPR_ID: NZ_CP022961_28
• CRISPR_location: 5238908-5239056
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP022961_28

Consensus_repeat	Method
GGGTCCGGCACGGCAGGGTCCGGCGCGGC	CRISPRCasFinder

spacers of NZ_CP022961_28

>28.1|5238937|31|NZ_CP022961|CRISPRCasFinder
CGGATCGGCCAGAGACGGACCTGGCGCGACC
>28.2|5238997|31|NZ_CP022961|CRISPRCasFinder
AGGGTCCGGCGCGGCAGGGTCCGGCGCGGCA

CRISPR arrays and Neighbor proteins around NZ_CP022961_28

CRISPR arrays

The CRISPR arrays of NZ_CP022961_28

>merge|NZ_CP022961|28|5238908-5239056|CRISPRCasFinder
CGGGCCGGCACGAAGCGGGCCGGCGCGACCGGATCGGCCAGAGACGGACCTGGCGCGACCGGATCGGCCACGATCGGGTCCGGCACGGCAGGGTCCGGCGCGGCAGGGTCCGGCGCGGCAGGGTCCGGCGCGGCAGGGTCCGGCACGGC

>NZ_CP022961|28|29|5238908-5239056|CRISPRCasFinder
CGGGCCGGCACGAAGCGGGCCGGCGCGAC	CGGATCGGCCAGAGACGGACCTGGCGCGACC
GGATCGGCCACGATCGGGTCCGGCACGGC	AGGGTCCGGCGCGGCAGGGTCCGGCGCGGCA
GGGTCCGGCGCGGCAGGGTCCGGCACGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095566485.1|5251315_5252056_-|hypothetical-protein	unknown	unknown	gnl|CDD|235825
NZ_CP022961.1|WP_095566477.1|5236846_5238247_-|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl|CDD|381169
NZ_CP022961.1|WP_095568051.1|5228711_5229368_-|YbjN-domain-containing-protein	unknown	unknown	gnl|CDD|371210
NZ_CP022961.1|WP_095566479.1|5239509_5240574_-|threonine-phosphate-decarboxylase	unknown	unknown	gnl|CDD|236128
NZ_CP022961.1|WP_095566480.1|5240697_5242863_+|glycosyl-transferase	unknown	unknown	gnl|CDD|273955
NZ_CP022961.1|WP_095566486.1|5252189_5252603_+|sulfurtransferase	unknown	unknown	gnl|CDD|236337
NZ_CP022961.1|WP_095566481.1|5243037_5243604_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NZ_CP022961.1|WP_095566476.1|5230799_5232476_-|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl|CDD|236992
NZ_CP022961.1|WP_095566474.1|5229513_5230275_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566475.1|5230267_5230795_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|223894
NZ_CP022961.1|WP_095566473.1|5228282_5228699_+|globin	unknown	unknown	gnl|CDD|381280
NZ_CP022961.1|WP_095566472.1|5226795_5228184_+|MFS-transporter	unknown	unknown	gnl|CDD|340863
NZ_CP022961.1|WP_095566470.1|5224524_5225058_-|HNH-endonuclease	unknown	unknown	gnl|CDD|224321
NZ_CP022961.1|WP_095568052.1|5232795_5234196_+|trehalose-6-phosphate-synthase	unknown	unknown	gnl|CDD|340820
NZ_CP022961.1|WP_095568053.1|5245949_5246690_+|SURF1-family-protein	unknown	unknown	gnl|CDD|119401
NZ_CP022961.1|WP_095566484.1|5248759_5250121_-|dipeptidase	unknown	unknown	gnl|CDD|236127
NZ_CP022961.1|WP_095566487.1|5252621_5253593_-|cobalamin-biosynthesis-protein	unknown	unknown	gnl|CDD|234919
NZ_CP022961.1|WP_095566483.1|5248461_5248668_-|hypothetical-protein	unknown	unknown	gnl|CDD|184470
NZ_CP022961.1|WP_095566471.1|5225318_5226557_+|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|366370
NZ_CP022961.1|WP_095566482.1|5246820_5248404_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|235108

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095566485.1|5251315_5252056_-|hypothetical-protein	gnl|CDD|235825	PRK06547, PRK06547, hypothetical protein; Provisional.	1.41668e-16
NZ_CP022961.1|WP_095566477.1|5236846_5238247_-|uroporphyrinogen-III-C-methyltransferase	gnl|CDD|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	1.36652e-101
NZ_CP022961.1|WP_095568051.1|5228711_5229368_-|YbjN-domain-containing-protein	gnl|CDD|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	6.57107e-15
NZ_CP022961.1|WP_095566479.1|5239509_5240574_-|threonine-phosphate-decarboxylase	gnl|CDD|236128	PRK07908, PRK07908, threonine-phosphate decarboxylase.	3.96311e-146
NZ_CP022961.1|WP_095566480.1|5240697_5242863_+|glycosyl-transferase	gnl|CDD|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	4.65182e-126
NZ_CP022961.1|WP_095566486.1|5252189_5252603_+|sulfurtransferase	gnl|CDD|236337	PRK08762, PRK08762, molybdopterin-synthase adenylyltransferase MoeB.	5.32822e-18
NZ_CP022961.1|WP_095566481.1|5243037_5243604_-|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	4.88299e-18
NZ_CP022961.1|WP_095566476.1|5230799_5232476_-|energy-dependent-translational-throttle-protein-EttA	gnl|CDD|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP022961.1|WP_095566475.1|5230267_5230795_-|acyl-CoA-thioesterase	gnl|CDD|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	4.75561e-23
NZ_CP022961.1|WP_095566473.1|5228282_5228699_+|globin	gnl|CDD|381280	cd14771, TrHb2_Mt-trHbO-like_O, Truncated hemoglobins, group 2 (O); Mycobacterium tuberculosis hemoglobin O like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). This group includes a Mycobacterium tuberculosis TrHb2, Mt-trHbO, encoded by the Mycobacterium tuberculosis glbO gene, which is expressed throughout the Mycobacterium growth phase. It also includes a TrHb2 from the thermophilic Thermobifida fusca ( Tf-trHb) which has a high thermostability and at the optimal growth temperature for Thermobifida fusca (between 55 and 60 degrees C ), it is capable of efficient O2 binding and release. Tf-trHb shares a relatively slow rate of oxygen binding with Mt-trHbO.	2.66348e-67
NZ_CP022961.1|WP_095566472.1|5226795_5228184_+|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.02214e-47
NZ_CP022961.1|WP_095566470.1|5224524_5225058_-|HNH-endonuclease	gnl|CDD|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	4.61678e-22
NZ_CP022961.1|WP_095568052.1|5232795_5234196_+|trehalose-6-phosphate-synthase	gnl|CDD|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	0
NZ_CP022961.1|WP_095568053.1|5245949_5246690_+|SURF1-family-protein	gnl|CDD|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	2.89108e-46
NZ_CP022961.1|WP_095566484.1|5248759_5250121_-|dipeptidase	gnl|CDD|236127	PRK07907, PRK07907, hypothetical protein; Provisional.	0
NZ_CP022961.1|WP_095566487.1|5252621_5253593_-|cobalamin-biosynthesis-protein	gnl|CDD|234919	PRK01209, cobD, cobalamin biosynthesis protein.	4.85203e-119
NZ_CP022961.1|WP_095566483.1|5248461_5248668_-|hypothetical-protein	gnl|CDD|184470	PRK14037, PRK14037, citrate synthase; Provisional.	0.00690168
NZ_CP022961.1|WP_095566471.1|5225318_5226557_+|mechanosensitive-ion-channel	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	7.94326e-38
NZ_CP022961.1|WP_095566482.1|5246820_5248404_-|ATP-dependent-DNA-ligase	gnl|CDD|235108	PRK03180, ligB, ATP-dependent DNA ligase; Reviewed.	0

Protein sequences

>NZ_CP022961.1|WP_095566477.1|5236846_5238247_-|uroporphyrinogen-III-C-methyltransferase
MSPDGEQVYPLALRLAGRRVLVVGGGSVATRRVPALLASGARVEVVAPELTPALRAHADAGRLSWTARRFVPADVDGAWLVQTAVDDPAAAAEVSAAAAERRVFCVRADDRTAATAWTPAVTRQGPVTVAVLGGHPRRAVAVRDAVAALLERDGTLLADPVPQGRPAGTRSGGHPGRVALVGAGPGDPELITVRGRRLLAEADVVVADRLVPGLLLDELRPEVELVDASKIPYGPARTQEEINRILVDRARSGAAVVRLKGGDPYVFGRGGEELLACTAAGVPVTVVPGVTSALAGPAAAGIPVTHRAVAHEFTVVSGHLAPEHPASLVDWPALARLRGTLVVLMGLRNLAAITATLQAHGRAPQTPAALVQEATTGGQRALRSTLAAVAADALRAGIRPPAVVVFGDVVEALAPAAGDPAAGDPSAGDAAAADDAAADDAAVDDPAVDDPAVDDPAVDDPAGPAA
>NZ_CP022961.1|WP_095568052.1|5232795_5234196_+|trehalose-6-phosphate-synthase
MAERSSFVVVANRLPVDEVTTPEGKQWRRSPGGLVTALHPVLVEHQGTWVGWAGGVGAAPEPFQLDGIGLHPVPLSAEELERYYEGQSNATIWPLYHDAVETPAYKRRWREAYRLVNARFAEAAAEVAADGATVWIQDYQLQLVPAMLRELRPDLRIGFFLHIPFPPIELFMQMPLRAEVLRGLLGADLVGFQQRLAAQNFVRLARHLLGLRYEGQMIQVDGRQVKAGAFPISIDVKEMERMAADPAVQARAKQIRAELGDPKTLILGVDRLDYTKGIELRLKAFRELLADGKVTVPETVMVQVATPSRERVEHYQALRVKVEREVGRINGEFGKVGVPAVHYLHQSYSRSELAALYCAADVMMVTPLRDGMNLVAKEYVACRADTGGALVLSEFAGAATELRQAFLCNPHDPDGVKDALLRAVHVDSVEARRRMRLMQRHLRSHDVGHWAQSFLRELGVLETEAA
>NZ_CP022961.1|WP_095566476.1|5230799_5232476_-|energy-dependent-translational-throttle-protein-EttA
MAQFIYVLDKARKAHGDKVVLDNVTLNFLPGVKIGVVGPNGAGKSSLLKIMAGIDQPSNGEARLMPGFTVGLLAQEPPLNDAKTVLGNVEEAVAETKARLERFNKIAEQMATDYSDELMEEMGRLQEELDHADAWDIDSKLELAMDALRCPPPDADVTQLSGGERRRVALCKLLLEAPDLLLLDEPTNHLDAESVQWLEQHLAKYAGTVIAITHDRYFLDNVANWILELDRGRAYPYEGNYSTYLEKKAARLAVEGRRDAKLKRRLGEELEWVRSNAKARQTKSKARLDRYDEMAAEAEKTRKLDFEEIQIPPGPRLGSLVIEAQELRKAFGDRVLIDDLSFSLPRNGIVGVIGPNGVGKTTLFKTIVGLEEPTSGAVRVGETVSLSYVDQNRQGLAGDKTVWEVVSDGLDYLMVGKVEMPSRAYIAAFGFKGPDQQKPTKVLSGGERNRLNLALTLKMGGNVILLDEPTNDLDVDTLSSLENALLEFPGCAVVISHDRMFLDRVATHMLAWEGDEENPARWFWFEGNFEAYEKNKIERLGDEAARPHRVTYRKLTRD
>NZ_CP022961.1|WP_095566475.1|5230267_5230795_-|acyl-CoA-thioesterase
MAGSDRRYVHDCVLRWSDLDAYGHVNNARFLTLYEEARVAMLFAGGRAAGLDSFAAGMVIRRHEVDYLRPVDYPMSWPDPDRAPTVRIELWVEDLRAARLTIGYELFAPAPPTGAAGAAGSAGSAGSADPGLVLAGRARSVLVPYDLVRQAPRRLSAEERDFLSRYVVEPVRVDG
>NZ_CP022961.1|WP_095566474.1|5229513_5230275_-|hypothetical-protein
MAEHGIAGTADAGALLSRLVRLDAAALVRLRPAAAGRIELWCRVPWGVLVGRTVAGRQVEVAGDEPTTGAGPAGSSAAGSAPAGSAGGSDATVLAAELLARLEAGAPQLPVRRDADWRWALPPSGARTVEELPVGELRRVSAAAQEALRAAAAHGVRGRAVGQRALRDALLDHVPIVVAPAAAGAAPVQVPQRLVQAVTRMGFLGADRPGADDRVLVRVAGGWTGLLAPYGVAWLAPVGPFTLRPRTGAEESR
>NZ_CP022961.1|WP_095568051.1|5228711_5229368_-|YbjN-domain-containing-protein
MPWWAWRPGQPGGDEPETRSMTSVDSVLRTGPPAPREPDHDGGAGGRAGAGMTDCPPTARSDRARSDLVIRPQLREAPSGVAPITLARVGMALDRLDMCYLADGGDSLLATWERHALLFSLEGPEDEILVIRARPHSTVPPDWADRAYRAVNEWNHTGRFCKAYVGDPTDRGNLPIYVELQVPFAAGAHDALLVEVVECGARSATEFVDWLHDEGALL
>NZ_CP022961.1|WP_095566473.1|5228282_5228699_+|globin
MNPYGESAQPAPTENFYEAVGGEPTFRKLVDEFYAGVARDPLLRPMYPEEDLAPAADRLALFLIQYWGGPGTYSSQRGHPRLRMRHAPFQVDAAARDAWLHHMRRAVDSLGLPPEQDRTLWDYLERAAYFMVNVAPEV
>NZ_CP022961.1|WP_095566472.1|5226795_5228184_+|MFS-transporter
MEALLPDKTHGRERPATFREVFAGSEYRALFAASALSWIGDYITKAAVMVLVYQQTSSVALSAAAFAVSYLPWLVGGPLLAAIAERYPYRNVMIICDLLRMVLVALVAIPGMPVWSLLALLFTTTLLTAPAQAARSATMPQILPGDRLVVGLSLNTSTGQAAQVLGYVLGAAIASVQPHYALLLDAATFAASATLIRFGIRFRLPATTGRARRHLLHETGDGFRLVFGRPVLRAIAILVFATTLFAIVPEGLAAGWADERTTTEAGRGLAQALIMASNPLGFIVGSLFVGRLLRPEVRQALVRPLAILAPVALVPALLDPSPIVVAGLSAVCGFAVAGLTPVANGLFVRALPDGYRARAFGVMATGLQITQGGAVLVTGLLADHFRIPMVVGVWSLAGVLLVGLAALYWPSPERFDQAIAAAQREAPGPEAPVLPGQPNGTDQGRPGRQTRPPGSPADAPAH
>NZ_CP022961.1|WP_095566471.1|5225318_5226557_+|mechanosensitive-ion-channel
MSPLFLRGPFVLAPVPSGSPSPDPSHDCLGDAFCKQVWDLTGSAWFADGSYWIIVKPLRIILILLGAMLIRFLLNRSISRLVRTTSRKAVPGILRPLRERPPAGAAEPGPVLPERRRQRAEAIGSVLRSGVTAVVFAIAALTVLSELSIDLGPLLTTAGIAGVAIGFGAQSLVKDLIAGLFMLIEDQYGVGDTVDLGEATGVVESVGLRVTTVRDGRGVLWYIRNGEIVRVGNKSQGWAMVVVDLPVGFGNTEEALTVLHDAAAQVAADPALAPSIVEPPEVLGVEQVTVDGPVIRTVAKTTASGQIAVGRRLRRQLAEALDEAGITARMAGGRGRPRPAVPGGSAGAAPESPPVAARGSAVGDEPGNDEYPGDTPGVTPSGSSDEFLSGPSADSPDEPLAEEDEDGSGRAS
>NZ_CP022961.1|WP_095566470.1|5224524_5225058_-|HNH-endonuclease
MPDIRPVAGSGALVLNATYEPLCVVSVRRAAILVLSAKAVCVCDGEGILHSARNALPVPSVVRLTRFVRVPYRTHVGLSRRAIFARDGWRCAYCRGAAETIDHVFPRSRGGRHAWENVVAACARCNHTKGDRTPAELGWRLHTVPAAPKGAAWRVLGHRTPDPRWADWLDLREPEAA
>NZ_CP022961.1|WP_095566479.1|5239509_5240574_-|threonine-phosphate-decarboxylase
MPDPDLGHHGDAEATPGLVDLAVNVRRAPPPEWLAGPVAAALGELARYPDPAPARAAVAARHRRPPDQVLLTAGAAEAFVLLARALAGVRRPVVVHPQFTEPEAALRAAGHRVDRVLLPAGTGFRLDPALVPADADLVLLGNPTNPTSVLHPAADIAALARPGRVLVVDEAFQDSTTAPGLPGEPESLAHRTDLPGLVVIRSLTKTWGLAGLRVGYLLAPADLVDRLAAVQPLWAVSTPALAAARACASPVAVAAEREIAAALAADRRHLVDRLAGLPGVRVEGVPAASFVLVHLAGADRVRLALRERGWAVRRGDTFPGLGADWFRVAVRDTATTDAFVTVLADLIGPGRATH
>NZ_CP022961.1|WP_095566480.1|5240697_5242863_+|glycosyl-transferase
MTQPDPSSSSRLAPVLRAGLIAGVALAAIAFPLVGAGGLGAKAFSNAVSDHPQDLRQVHPAQTTYVYAADGRTLLTMFYEEHRKYVPINQISPYMQQAIVAAEDSRFYQHHGVDAKGVVRAFVANQQAGGVSQGASTLTMQYVRMALRDGAQTPKEALEATQQTSVRKVREMEMAVEVEKEMTKSEILERYLNSAYFGHRAYGIYAAAEIFFSKRPADLTPLEAATLAGLVKAPSEYDPASSDQKEATDRRNYVVERMRVMGYVSAQDAAAYKTQPITLRLTTPPNDCVSIDKQYNSWGFFCDYLKAWWGQQPAFGDNYYEREDKLRRGGYNIVTSIDPRVQKIAEEQVASRESTGSPFAHGVVVVEPGTGRVKAMAVNRIYSLDQSQNSPNSNAALRGKVPGNYPNTVVPLLGGGDLPGYQAGSTFKMFTMLAALNAGIPLSASFNAPYKITSIYPDGSGGPTDCGGLWCPSNASGAMTGNQTMWSGFGKSVNTYFVWLEQKVGVDKVVEMAEKLGLKWRTDIDKTLASPMKRRLWGSFTLGVSDVTPLEMAGAYAAVAADGRYCEPLPVLSVSNPDGTPATYQTADGTTVPVAKGRCQQVFSPDVARAATDAARCPTGDKPARGGCGGWSTADSVRGTVGRPVAGKTGTTDSTRSAWFVGYTPELAAASFISDPDNPNNAVGDGQSNKPVDTVANTLKGALKDQPVRQFSAPSDAMVGS
>NZ_CP022961.1|WP_095566481.1|5243037_5243604_-|GNAT-family-N-acetyltransferase
MTGDVAVRRFPRLTVSTPRAHVRPLTGHDADAVAEVFGDKLTLRWLPLPQPGTVDAVRWCTEAAQERRDSGSGDHYGVVRREDDRLVGCLWTKRTDWACRVTEVSYAIAPEARGFGLAAEAVDAAAIALILEHGFHRVEVRVAPGNTPARRVVEKAGFSYEGLLRNAGYVQGGRVDLEVWSFVAADLG
>NZ_CP022961.1|WP_095568053.1|5245949_5246690_+|SURF1-family-protein
MVLLGDWQLHRYQQRAAINGRIDASATAAPVPVDRVLPPAGTAAGSAGAEPPADAEWTRVTVTGEYDPANLILIRGRTVDGQVGFEVLTPLRTAGGHAVLVDRGWIPPAPGAATVLPQVPATPSGAVTVLARVRRSESRPDTVQHRGGRLESRRISVPRLAAELPYPVYGGYLLLDEQTPAADPAFVAIPVEHQNDWQNAGYVVQWWLFAGMALFGYGWAARREARGGPTAAGPDADRVPAVAAGP
>NZ_CP022961.1|WP_095566482.1|5246820_5248404_-|ATP-dependent-DNA-ligase
MRFLDLAATSAAVTAISGRRAKVDLLAAALRDLRIDEISIGAAYLAGELRQRQTGVGYASLRDLPPPAAEPELSVTEVDAAIEELSAVAGSGSQQRRRALLAALFARSTTDEQRMLVGLFSGELRQGAQAGLLADAVARAAQVPLPLVRRALLMAGDLRAVAVAALTGGAAALGEFSLRVGRPLAPMLAQSASSVDEALGATGSPAVVDVKLDGIRIQVHRSGNDISVFTRSLDDITVRLPEVVAAVRALPARELVLDGEAIALDATGRPRPFQETASRAATRGARRRLAAGAASAAPAPSAPGSGTTTLTPYFFDLLHLDGTDLLDAPGRDRWAALAATVAPALVVGRLEVHSAEEAASAFATAIDAGQEGVVIKAPDAPYDAGRRGAAWVKVKPRHTLDLVVLAVEWGSGRRRGWLSNLHLGARDPDTGGFVMLGKTFKGLTDELLRWQTERFLDLAVERGEWVVRVRPEQVVEIAFDGVQSSSRYPGGMALRFARVVRYRDDKTAAEADTIDAVRAIHGGRPPG
>NZ_CP022961.1|WP_095566483.1|5248461_5248668_-|hypothetical-protein
MSTKDAIARLDAAVSALGDVDVSTWSDDMLKDQLAELSTALVALDAALSRVADGIRARGLRVEEPVAA
>NZ_CP022961.1|WP_095566484.1|5248759_5250121_-|dipeptidase
MISPMPTESDLRAAIEREFPGVRADLERLVRIPGIAFDGFDHSHVERSAEAVAELLRGCSLDVRIVRSGGQPAVIGTRPAPPGAPTVLLYAHHDVQPVGDLSLWQSEPFEPVERDGRIFGRGAADDKAGIMAHVAALRAYGDRLPVGVVLFIEGEEEFGSESLERLIAEHQADLAADVMVIADSGNWDIGRPALTTSLRGMVNCFVEVRTGTHPVHSGMFGGAVPDAVTALARLLATLHDDAGDVAVDGLVARTGATVDYPHDRLRAEAGMVDGVQFIGTGALTDRIWTKPALSVLGVDAPPTTGAPNAIVPVAKAKLSLRLAPGDDPKRAYAALVGHLEKHAPWGAQVTVTFEHDGDACEIDSSGPMYDAARAAFTAAWDGTQPVDMGVGGSIPFIATFQQMFPNAAILVTGVEDPDSRAHGPNESLHLGEFARVCLAEALLLAKVAEAGRG
>NZ_CP022961.1|WP_095566485.1|5251315_5252056_-|hypothetical-protein
MSRGQTYPQLARRIRSAPARLGAVRLVAVDGPSGAGKTYFTERLAAALRRADNRTGTAEPVTVLHTDDLLDGWSDQFTFWRRLDERVLRPLRSGRPGGYHRYDWDSGRFTEALVPVPAAGVLLLEGVSAARAAIRPELTLAVFVTAPDRLRLDRVLARDGARIRPQLLRWRAAEAEHFAADRTAAAVDLVIDGVAGEGRSWGISTRDCAEAWSPGMDATARLGHDRDGPAGDPIRGGPAGDGGSGP
>NZ_CP022961.1|WP_095566486.1|5252189_5252603_+|sulfurtransferase
MRQSSDRGVDALLARARAGIRRLSPRETLVARERGALVIDTRTETQRAEQGELPGALVIDRTVLEWRVDPDSPWRIPEATDHDVEIIVVCHQGYSSSLAAATLRALGLHRATDMVGGFAAWRDCGLPVSPGPADVRR
>NZ_CP022961.1|WP_095566487.1|5252621_5253593_-|cobalamin-biosynthesis-protein
MADAVGLAAGYALDAALGDPRRWHPVAGFGTAASALERRLYRDSRTAGAAHTAVAVGAAVLAGAAGAALTRRRPVARAALVAAGTWAVLGGRTLGVEGRAMADALSRDDLPAARGRLGHLCGRDPSALDEAELARATVESVAENTSDAVVAPLFWGAVAGLPGLLAYRAANTLDAMVGHRSARYARFGTPAARLDDLLNLAPARVTGLLTILLGPVAHGDRHRAWQVWRRDRADHPSPNAGQCEAAMAGVLGVRLGGRNVYAGRVEVRPYLGDGPRPEFRHIRRAVRISRAVGLAAALGAVVVATSRSAARAGSAAAGSAAAV

Crispr_ID: NZ_CP022961_29

• CRISPR_ID: NZ_CP022961_29
• CRISPR_location: 5330640-5330746
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_29

Consensus_repeat	Method
GTGCCGGTCGCTCTCGCCGTGCCGGTGCCGGTCGC	CRISPRCasFinder

spacers of NZ_CP022961_29

>29.1|5330675|37|NZ_CP022961|CRISPRCasFinder
TCTCGCGGTGCCGGTGCCGGTGCCGGTCGCTCTCGCC

CRISPR arrays and Neighbor proteins around NZ_CP022961_29

CRISPR arrays

The CRISPR arrays of NZ_CP022961_29

>merge|NZ_CP022961|29|5330640-5330746|CRISPRCasFinder
GTCCCGCCCGCTCCCGCCGTGCCGGTGCCGGTCGCTCTCGCGGTGCCGGTGCCGGTGCCGGTCGCTCTCGCCGTGCCGGTGCCGGTCGCTCTCGCCGTGCCGGTGCC

>NZ_CP022961|29|30|5330640-5330746|CRISPRCasFinder
GTCCCGCCCGCTCCCGCCGTGCCGGTGCCGGTCGC	TCTCGCGGTGCCGGTGCCGGTGCCGGTCGCTCTCGCC
GTGCCGGTGCCGGTCGCTCTCGCCGTGCCGGTGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095566550.1|5325744_5326476_+|class-F-sortase	unknown	unknown	gnl|CDD|320678
NZ_CP022961.1|WP_095566552.1|5334294_5335023_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NZ_CP022961.1|WP_095566558.1|5344209_5345181_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl|CDD|224617
NZ_CP022961.1|WP_095566551.1|5332061_5334119_+|penicillin-binding-protein	unknown	unknown	gnl|CDD|223839
NZ_CP022961.1|WP_095566557.1|5342486_5343401_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|224137
NZ_CP022961.1|WP_095566554.1|5335378_5337082_-|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|367155
NZ_CP022961.1|WP_157756896.1|5335032_5335179_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566545.1|5318853_5320512_+|sodium:solute-symporter-family-protein	unknown	unknown	gnl|CDD|271372
NZ_CP022961.1|WP_095566548.1|5321465_5323286_-|cellulose-1,4-beta-cellobiosidase	unknown	unknown	gnl|CDD|376532
NZ_CP022961.1|WP_095566555.1|5339362_5340310_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|225660
NZ_CP022961.1|WP_095566544.1|5317438_5318701_+|hypothetical-protein	unknown	unknown	gnl|CDD|227596
NZ_CP022961.1|WP_095568061.1|5343592_5344024_-|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl|CDD|377129
NZ_CP022961.1|WP_095566559.1|5345177_5346419_-|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261
NZ_CP022961.1|WP_095568060.1|5323706_5324615_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP022961.1|WP_095566546.1|5320525_5320864_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566543.1|5316830_5317424_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566549.1|5325011_5325761_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022961.1|WP_095566547.1|5320926_5321286_+|hypothetical-protein	unknown	unknown	gnl|CDD|237940
NZ_CP022961.1|WP_095566556.1|5340503_5342192_-|hypothetical-protein	unknown	unknown	gnl|CDD|239652
NZ_CP022961.1|WP_095566542.1|5315996_5316599_-|ATP-binding-protein	unknown	unknown	gnl|CDD|225138

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095566552.1|5334294_5335023_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.37097e-20
NZ_CP022961.1|WP_095566551.1|5332061_5334119_+|penicillin-binding-protein	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	4.80374e-63
NZ_CP022961.1|WP_095566557.1|5342486_5343401_-|glycosyltransferase-family-2-protein	gnl|CDD|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.33304e-36
NZ_CP022961.1|WP_095566547.1|5320926_5321286_+|hypothetical-protein	gnl|CDD|237940	PRK15313, PRK15313, intestinal colonization autotransporter adhesin MisL.	0.00284821
NZ_CP022961.1|WP_095566554.1|5335378_5337082_-|DUF222-domain-containing-protein	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.59294e-36
NZ_CP022961.1|WP_095566558.1|5344209_5345181_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl|CDD|224617	COG1703, ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism].	1.20589e-117
NZ_CP022961.1|WP_095566545.1|5318853_5320512_+|sodium:solute-symporter-family-protein	gnl|CDD|271372	cd11478, SLC5sbd_u2, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP022961.1|WP_095566548.1|5321465_5323286_-|cellulose-1,4-beta-cellobiosidase	gnl|CDD|376532	pfam01341, Glyco_hydro_6, Glycosyl hydrolases family 6.	3.01862e-108
NZ_CP022961.1|WP_095566544.1|5317438_5318701_+|hypothetical-protein	gnl|CDD|227596	COG5271, MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only].	5.26816e-06
NZ_CP022961.1|WP_095568061.1|5343592_5344024_-|Asp23/Gls24-family-envelope-stress-response-protein	gnl|CDD|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	2.21851e-15
NZ_CP022961.1|WP_095568060.1|5323706_5324615_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	6.27801e-07
NZ_CP022961.1|WP_095566559.1|5345177_5346419_-|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP022961.1|WP_095566550.1|5325744_5326476_+|class-F-sortase	gnl|CDD|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	5.78887e-58
NZ_CP022961.1|WP_095566555.1|5339362_5340310_-|tetratricopeptide-repeat-protein	gnl|CDD|225660	COG3118, COG3118, Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones].	2.48616e-65
NZ_CP022961.1|WP_095566556.1|5340503_5342192_-|hypothetical-protein	gnl|CDD|239652	cd03680, MM_CoA_mutase_ICM_like, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM from S. cinnamonensis is comprised of a large and a small subunit. The holoenzyme appears to be an alpha2beta2 heterotetramer with up to 2 molecules of coenzyme B12 bound. The small subunit binds coenzyme B12. ICM catalyzes the reversible rearrangement of n-butyryl-CoA to isobutyryl-CoA, intermediates in fatty acid and valine catabolism, which in S. cinnamonensis can be converted to methylmalonyl-CoA and used in polyketide synthesis.	0
NZ_CP022961.1|WP_095566542.1|5315996_5316599_-|ATP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	2.77978e-41

Protein sequences

>NZ_CP022961.1|WP_095566550.1|5325744_5326476_+|class-F-sortase
MVRSPERASRFAGGRRGVPRRAAGIALLSLLVLMLIAGAGMVTAAFTVDSAAPPQPAAEFAPAPTAASTAQPSATAGRAATPAPPAVSLGRSTPTRLVIPKIKVDTKLLSLGVNKDDTIQVPDVRKQPKLAGWYKLGPSPGEIGNAVIVGHVDSKAVGPAVFFRLGSLKPGDQIKVTRADKKVVTFRVDAVGSYPKTAFPTDLVYSPSDQAGLRLVTCGGTFDRKKHSYQNNIVVLATAVSAK
>NZ_CP022961.1|WP_095566549.1|5325011_5325761_+|hypothetical-protein
MAKKFLGKVVAGAALGGAALLLGAPGIALADAAPTHDPDAHDKSGTVWVNPRVVRPGETVDIGEVCTEAQASPRAWSKLTGQLTLHEVPYDPERAAEHARLGAQYAGTGDSDEAGPDAGPPVTASPAASPSASASGGTGGGVLADDGHGKGPRPPMEDGAAQEMSSDADPHVYVVEHELSEDARPGHYTVYAACGEAELIVSPDGPVNGGDGGAAVNKGLATGGAGALAAAAITGVALLRRRRTHGSIA
>NZ_CP022961.1|WP_095568060.1|5323706_5324615_-|hypothetical-protein
MKPPFSRWLPAIAHTRTTLRRSAPGLFRVPALARSGRVARYASAATRTVPAMARYPVPRGAILAATGLTAAAALAGQPLAGAQSAAPEAARPAALTDAATAAPGGADAGNPGDRGAAAGVPVQPPADPAQPADGAAADDGAAAAGEDAAQPEAAPSLQALIPYGTQGPQSRVNLTSEQTDNARTIVRTARRMNLPDRAAVIGVATSLQESKLDNLGHLGAANDHDSLGLFQQRPSAGWGSPDQVTDPQYAAMAFFNGLRNVPDWQNLPLTDAAQRVQVSAFPFAYAQWEQQAADIVRDVWDR
>NZ_CP022961.1|WP_095566548.1|5321465_5323286_-|cellulose-1,4-beta-cellobiosidase
MNAWNNLTGRRKGAVLASVGALVAGGMVALPATMAQAATGCDVQYTTNDWSGGFTANISIKNLGDPMSSWTLRWTFPNSSQRVDQGWSATYTQSGQQVTAASLSYNGSLGTGASTSIGFNGSWSGSNPKPTSFTLNGVTCTGGTTNPTTGGPTSSPTSSPTSSPTGGPTSSPTSSPTGGPTTPPPTGGKVDNPYVGARGYVNPEWKAKAESVSGGSRVSNNPTAVWLDRIAAIEGTSGSSSNGAMGVRDHLDAALAQGAGYIQFVIYNLPGRDCAALASNGELGPDELPRYKSEYIDPIAAIQADSKYAGLRIINIIEIDSLPNLITNTSGQAGGTAMCDTVKANGAYVNGVGYALAKLGAINNVYNYIDSAHHGWIGWDSNFGPTADILHQAATASGSTVNNVAGFITNTANYSALQEPYVKITDTVNGTSVRQSKWVDWNQYVDELSFAQAFRQKLVSVGFNSNIGMLIDTSRNGWGGSARPTGAGPTTSVDAYVDGGRIDRRIHAGNWCNQSGAGLGERPTAAPASGIDAYVWIKPPGESDGSSTEIPNDEGKGFDRMCDPTYTGNARNGNSATGALPNAPISGAWFPAQFQQLMQNAYPPLS
>NZ_CP022961.1|WP_095566547.1|5320926_5321286_+|hypothetical-protein
MTDREPIRPVEDDPAFADAVDDDTTVPQLAERGPADPDTPTFTEPGAGSGDFPPTDDLLGDPYGAGSNNAADYRTGAEQPWEAEDLARAEGRDPTPENVSRAQRELDEDGPAAVERTVP
>NZ_CP022961.1|WP_095566546.1|5320525_5320864_+|hypothetical-protein
MDDNTGRAPEVEEGAEDTLVEETEQEQRRSAAARLFDIRRVIGGLFAAYGLIVTLMGVFDSKTEIDKAQGLRINLWAGLAMLAFGLFMLGWAVLRPAEAPEPRDGEDATAGD
>NZ_CP022961.1|WP_095566545.1|5318853_5320512_+|sodium:solute-symporter-family-protein
MDGGGLRLDMNVLDYVLLALYFATVLGVGFAARRAIRTSVDFFLSGRSLPAWVTGLAFVSANLGALEIIGMAANGAQYGMMTVHYYWIGAVPAMVFLGIVMMPFYYGSKVRSVPEYLRLRFNRPTHLLNAISFALAQVLIAGVNLYALALIMQALLGWPLWVAIVVGAAIVLAYILLGGLSGAIYNEVLQFFVILAGLIPITVIGLVKVGGVNGLLDAVRGSKLGEAGLHAWADTAGTDNPLGAQWWGIVFGLGFVLSFGYWTTNFAEVQRALSARNMSAARRTPIIAAYPKLLIPAVTVIPGLIALVTVKGLGADTGDLQYNNAIPLLMRDLLPNGVLGVAVTGLIASFMAGMAANVSGFNTVVSYDIWQAYIQRDRTDDHYLRVGRVATVVGVLIGIGTAFIAAGFSNIMNYIQALFSLFNAPLFGTFIVGMFWKRMTAWAGFWSLLVGTLGALATYLLYQGGVIDFNSDLEESFWGAGIAFLLVLVVAAVVTPMTSPKPERELRGLVSGLGGVDLHGDTLVGDRVWYRNPVLLGVVAVVLAILFYIPVF
>NZ_CP022961.1|WP_095566544.1|5317438_5318701_+|hypothetical-protein
MRHHDQINDEHPDVVKSDPVPVPPPARDGMDDPNDLDDRDTDLADRDTDLDAEAAERPEHGPEHGDSFDDPVLAEPVDGPDAGTERLDDGDADGHDPDGADASLDDRLDEARNNDLIDDEPAPGDRTAETAVDAPLYGEPADERDADGFAEPAPQPTAFGAGSPGGAVAASAMAGDGRPTEHDVDETDLDRTEDGALDDDVDADATVAEAGDNADADALDNDAVDNEALDDDAVDVEPVAAAEDDPDARTMPDETAAGTDSPEDGTDSPEEAADVLAPADIVESDTDTVAHPDTVESDTVVPTDTVDTGTVDTGTASPTGDGALPPGAVPTEPVTALIGDRAGDFRDRWRDVQLRFVDDPQAAVGEAQGLVDEAIEALAAALSRQKDELGTWRQDGTNDTEQLRVLVRRYRDFLDRVLGL
>NZ_CP022961.1|WP_095566543.1|5316830_5317424_+|hypothetical-protein
MSSIAIVVIVIVIVILAAVVAAAVVATRRRALRSRFGPEYDRVLAEQDSRSAAERELRGRERRHAELTLTPLTDESRERYASAWEEIQARFVDEPTEAVGAADELVTRLVAERGYPTEDYEDQLAHLSVEHARTLTHYRDAHEINLANARGEASTEQLRQAVVHYRTLFAELLGEDPVPHTRPDEPRPDTPQDAPSR
>NZ_CP022961.1|WP_095566542.1|5315996_5316599_-|ATP-binding-protein
MNALDPADGAGVRRLPVALKILIAGGFGVGKTTLVGAVSEIRPLHTEEVLTSLGAGTDDLTGVEAKTTTTVAMDFGRITINEQLQIYLFGTPGQARFWFLWDELAYGALGAVVLADTRRLADCFPSIDYFEERNIPFVVGVNSFDGVPRFGVAAVREALDLGPEVPVLRCDARDRQSGRDLLVALVEHVAQRRGELVSVT
>NZ_CP022961.1|WP_095566551.1|5332061_5334119_+|penicillin-binding-protein
MRAAYLVRAESPLRRGRLRAKPAGAGHRVRPARRPPAWVRPTRRLPAALAGLSLLAAGLSGCSSPGPESALDAFLAGWRDGTLDKLAFIDPSGRKLPATDVADELKHLTGDLAGAVPGLRVDGKVTGNGGLATATVAVDWPLPGDGHWTYPTTVRLKQGQDDAWQIIWEPKLVQNDLTSGDQLSVTRLPAKRGDVLDAAGKPLVTSRPVVLVGVDPGQVTDAKDLTRKLDEAFRAIRPPLTPPIDLGDLPERIAAGTPGSRVEVVTLRKDAYDQIRSRIRPLPGTVFLTAERELSPSREFGRAVLGTVDDVQKQDIDADPATYGYGDRVGHGGIAGAYDKQLRGVPGASVQIMRQDPEGALKPISEVFRREPQPGAALRTRLDTGTQTAADAAVATQPGHRTALVALRISDGSILAAANGPGAAEENLAFTAQVPPGSTFKMVTALGLLDAGAVQAETPVDCPKTFLVEGRTFKNSDFFELGTVPFRTDFAKSCNTAFAALAPKLGADGLAAAGRTLGLEGSWQVGLDAFTGKVSTGGPGVERAAAAIGQGTTLVSPLAMACATAAVARGQWSQPTLVAPDTPDVPAAAGPGPQLKAGSVEPLRAMMREVVTAGTATSLAKVPGDPVYGKTGTAEYDNDPAHAHAWFVGWQGDIAFAVFVEQGGSSTASAVPIAEKFLRALPARR
>NZ_CP022961.1|WP_095566552.1|5334294_5335023_-|class-I-SAM-dependent-methyltransferase
MPDPIFAERRLAAIYDPLDPDRSDLDAYLAMADEFGARSVLDVGCGTGTFACLLAERGLAVIGMDPAAASLEVARAKPGADRVRWIHGYVTDLPALQVDLVTMTANVAQVFLTDEDWTAVLRAAYAALRPGGRLVFETRDPAARAWLEWNHDRSHQRTVVPGVGAVESWVDLLGVHGDLVSFRGSYVFAADGARLTSESTLRFRHRDEVSTGLTATGFAVRDVRQAPDRPGREMVFVAQRPD
>NZ_CP022961.1|WP_157756896.1|5335032_5335179_-|hypothetical-protein
MTSTPVMNPTALMTSIAVMNPTTLMNTTALMRQAGHSADGPLLLGRGA
>NZ_CP022961.1|WP_095566554.1|5335378_5337082_-|DUF222-domain-containing-protein
MRGALVRAGKAVDDCLDLPLWSLTEPELVAALDAAVLVQRRAMALVLGLVREVDRVGVARQQGATSTTAWLRHRLRLSPRVARTLVGDAEALDSGPVLVRDAVRSGAVDAEQARVVATAVATVRAQAGAMAADKAVGVLLEWAGQFDPEGLRKLSQRILDHVAPQVAEQADAEAVARAEQRARRDRHLNLSPTGDGRLRLSGLLDTETGALLRAALDPLSRPHGRDDDRTPAQRRHDALADVCRLVLRCGEVPDGGGEPAQVVVTTGFDPLAGQLGTGTLDSGERLSAESVRRLACDAAILPAVLDGPGQVLDLGRQRRLFTGPVRRALLLRDGGCAFPGCDRPPSWTQAHHIVHWSAGGATAADNGVLLCGRHHRVVHHDGWVVRMAGDRLPEFVPPPWLDPRQQPVRNTHHRRSPAPTGKSPSAAHRHQSAPPGAAAPQAYPRQSAPPGTAARPVPPMDRRRPASPGTVVPPVPPVDRGQPASVGTAARPASPADRRRPGSSGAVVPPATPAHRRHSDRPAVVEPGVEPGGHRTAAPRAGRSVSEPVGRGAGESGRPGPTRRLVA
>NZ_CP022961.1|WP_095566555.1|5339362_5340310_-|tetratricopeptide-repeat-protein
MSDPRTSPSIFTRGAVDLSALRGPSTNAPAARPAAGAATPPGGAAGGVPGGAGTGPRAGGVAVVDVTEATFQSEVLERSMTTPVVIDFWAAWCEPCKQLSPVLERLAAEGGGAWVLAKIDVDANPRIAQMFRVQGIPMVYAVVGGQPLDAFSGVVPEAQLRQWIGAVLKAGGVATEEPEDPRLTEADDALMSGDLEAAERAYRKILAEAPADAAAEAGLAQVGLARRVAGVDPGQVLAAAAANPDDVPAQLLAADVEVLSGQAEQAYARLVGVVRRTAGDEREQVRQHLVSLFTVAGPDDPAVAAARRALASALF
>NZ_CP022961.1|WP_095566556.1|5340503_5342192_-|hypothetical-protein
MNADEIAAGRARWQARYDAARKRDADFTTLSGLRLDPVYGPPEGTGHPGFERIGWPGEYPYTRGLYPTGYRGRTWTIRQFAGFGNARQTNERYKMILGAGGGGLSVAFDMPTLMGRDSDDQQSLGEVGHCGVAIDSAADMQALFDGIDLAAVTTSMTISGPAVPVFCMYLIAAERQGADPSTLDGTLQTDIFKEYIAQKEWLFEPDPHLRLIGDLMEYCAREIPRYKPLSVSGYHIREAGSTAAQELAYTLADGFGYVELGLSRGLDVNRFAPGLSFFFDSHVDFFEEIAKFRAARRIWARWLRDVYGATDERALWLRFHTQTAGVSLTAQQPVNNVVRTAVEALAAVLGGTNSLHTNALDETLALPTDESAEIALRTQQVLMEETGVTNVADPLGGSWYVEALTDKIEAEAEEIFARIRQLGGEGPHRIGPMTSGILRGIEDGWFTAQIAEAAFVYQQALEKGDKKIVGVNCHTGTVAKELEILRISHEVEVEQRRALADRRSGRDTAAVEAALKRMVEVARTAENMIPAMLDAVRAEATLGEICDALRAEWGVYREPARF
>NZ_CP022961.1|WP_095566557.1|5342486_5343401_-|glycosyltransferase-family-2-protein
MNGDQETIAVVVVTYHSEAVLPELLDSLGPGLAGLSWHLTIADNSADPAALATLRRLAPTARIVDLGRNAGYAAGINAAVAAAAAYTAILVLNPDVRLAPRCGPELLSVLRRTGAGIAVPRLERADGSALASLRREPTLLRALGDAVLGGHRAGRLSLGELVLGERHYRTESTADWATGAAMLIAAECWRRCGPWDESFFLYSEETDFALRARDAGLATVLAPGARAVHLEGDSKRSPWLWTLLTLNRIRLYRRRHRLGPVLAYWAVLLLREVSRAATGNPASRAAAAALLRPSRLRATPGPRG
>NZ_CP022961.1|WP_095568061.1|5343592_5344024_-|Asp23/Gls24-family-envelope-stress-response-protein
MGRVEPLRPVIDEADPARGATRISGEVVEKIAAAAAKEVPGVVELGGDVARFVNSVLDRVGLTELGDARRGVSATVNGGDAAVDIVIVIDGGHVVHEVTEAVRARVADAIRRFGLRVTAVNVEVDDVALDGVPGNPSAQGGQA
>NZ_CP022961.1|WP_095566558.1|5344209_5345181_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MSPSLRRSRDVPALVDAARAGDPRAVARLITLVESGDELLPEIAVALTPHTGTAQVVGLTGSPGVGKSTTTNELVRALRRGGHRVGVLAVDPSSPFTGGAILGDRVRMQDHATDPGVYIRSMSSRGHLGGLAAAAPQAVRVLEGAGCDVVLVETVGVGQAEVEIASLADTTVVLLAPGMGDAIQAVKAGILEIADVFVVNKADRDGVDATIRDIQGMIALGERAPGQWRPQVVRSVASRGEGIDDIAAAIDKHRRWLDDHGELRRRREARAAAEVEAIVLGVLRTRMAALRDGTALGTLATKVADGSMDPYAAARQLLGEIEH
>NZ_CP022961.1|WP_095566559.1|5345177_5346419_-|acetyl-CoA-C-acetyltransferase
MDTVSAGSERGESRGTRRAAGSVIVAGARTPMGRLSGNLKDLSATRLGGVAIKAALERAGVAPEQVEYVIMGQVLQAGAGQIPARQAAVEAGIPMTVPALTVNKVCLSGLDAIALADQLIRAGEFDIVVAGGMESMTNAPHLLIGQRQGYKFGDVTMKDHAALDGLTDPWDCCSMGESTERHGTTRNITRQEQDEFAVASHQRAAAAQKNGVFAEEIVPVQIPQRRGEPVVISEDEGIRPETTVETLAKLRPAFTPDGTITAGSSSPITDGAAAVVVMSRAKATELGLTWLAEIGAHGNVAGPDNSLHSQPSNAIRHALGKAGRTVADLDLIEINEAFAQVGIQSTRDLGVRPEIVNVNGGAIALGHPIGMSGARLVLTLALELRRRGGGTGAAALCGGGGQGDALIIDVPAV

Crispr_ID: NZ_CP022961_30

• CRISPR_ID: NZ_CP022961_30
• CRISPR_location: 5792688-5792782
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022961_30

Consensus_repeat	Method
CGCGCCGGAGAACGCCCCGGCCG	CRISPRCasFinder

spacers of NZ_CP022961_30

>30.1|5792711|49|NZ_CP022961|CRISPRCasFinder
GACCGCACACCACCACGGGGCCGCACACCACCACCGGGCCGCACCCAGT

CRISPR arrays and Neighbor proteins around NZ_CP022961_30

CRISPR arrays

The CRISPR arrays of NZ_CP022961_30

>merge|NZ_CP022961|30|5792688-5792782|CRISPRCasFinder
CGCGCCGGAGAACGCCCCGGCCGGACCGCACACCACCACGGGGCCGCACACCACCACCGGGCCGCACCCAGTCGCGCCGGAGAACGCCCCGGCCG

>NZ_CP022961|30|31|5792688-5792782|CRISPRCasFinder
CGCGCCGGAGAACGCCCCGGCCG	GACCGCACACCACCACGGGGCCGCACACCACCACCGGGCCGCACCCAGT
CGCGCCGGAGAACGCCCCGGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022961.1|WP_095568114.1|5802683_5803670_+|deoxyribose-phosphate-aldolase	unknown	unknown	gnl|CDD|188646
NZ_CP022961.1|WP_095566861.1|5798678_5800388_+|phosphomannomutase	unknown	unknown	gnl|CDD|100092
NZ_CP022961.1|WP_095566858.1|5792928_5794188_-|amidohydrolase	unknown	unknown	gnl|CDD|349936
NZ_CP022961.1|WP_095566860.1|5796619_5798602_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP022961.1|WP_095566854.1|5788459_5788915_+|gamma-glutamylcyclotransferase	unknown	unknown	gnl|CDD|372719
NZ_CP022961.1|WP_095566863.1|5801920_5802553_-|uracil-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234653
NZ_CP022961.1|WP_095566849.1|5780261_5780759_+|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NZ_CP022961.1|WP_095566850.1|5780752_5782486_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP022961.1|WP_095566851.1|5782514_5784596_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP022961.1|WP_095566848.1|5778702_5780142_+|GuaB1-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl|CDD|181127
NZ_CP022961.1|WP_095566856.1|5790947_5791580_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|316044
NZ_CP022961.1|WP_095566847.1|5776937_5778692_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|227111
NZ_CP022961.1|WP_095568113.1|5800468_5801149_-|GPP34-family-phosphoprotein	unknown	unknown	gnl|CDD|377552
NZ_CP022961.1|WP_095566853.1|5786949_5788353_-|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl|CDD|236112
NZ_CP022961.1|WP_095566864.1|5803675_5805139_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143429
NZ_CP022961.1|WP_095566859.1|5794831_5796415_-|hypothetical-protein	unknown	unknown	gnl|CDD|376584
NZ_CP022961.1|WP_095566865.1|5805131_5805974_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143410
NZ_CP022961.1|WP_095566852.1|5786271_5786943_+|DedA-family-protein	unknown	unknown	gnl|CDD|223659
NZ_CP022961.1|WP_095566855.1|5788987_5789953_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP022961.1|WP_095566862.1|5801325_5801817_+|8-oxo-dGTP-diphosphatase	unknown	unknown	gnl|CDD|239519

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022961.1|WP_095568114.1|5802683_5803670_+|deoxyribose-phosphate-aldolase	gnl|CDD|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	1.75583e-77
NZ_CP022961.1|WP_095566861.1|5798678_5800388_+|phosphomannomutase	gnl|CDD|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP022961.1|WP_095566858.1|5792928_5794188_-|amidohydrolase	gnl|CDD|349936	cd08014, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of uncharacterized bacterial proteins predicted as putative amidohydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	1.32134e-168
NZ_CP022961.1|WP_095566860.1|5796619_5798602_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.09396e-98
NZ_CP022961.1|WP_095566854.1|5788459_5788915_+|gamma-glutamylcyclotransferase	gnl|CDD|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	3.72804e-21
NZ_CP022961.1|WP_095566863.1|5801920_5802553_-|uracil-phosphoribosyltransferase	gnl|CDD|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	3.4924e-96
NZ_CP022961.1|WP_095566849.1|5780261_5780759_+|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.39438e-18
NZ_CP022961.1|WP_095566850.1|5780752_5782486_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.68848e-161
NZ_CP022961.1|WP_095566851.1|5782514_5784596_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP022961.1|WP_095566848.1|5778702_5780142_+|GuaB1-family-IMP-dehydrogenase-related-protein	gnl|CDD|181127	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein.	0
NZ_CP022961.1|WP_095566856.1|5790947_5791580_-|MBL-fold-metallo-hydrolase	gnl|CDD|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	4.74248e-21
NZ_CP022961.1|WP_095566847.1|5776937_5778692_+|ATP-grasp-domain-containing-protein	gnl|CDD|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP022961.1|WP_095568113.1|5800468_5801149_-|GPP34-family-phosphoprotein	gnl|CDD|377552	pfam05719, GPP34, Golgi phosphoprotein 3 (GPP34). This family consists of several eukaryotic GPP34 like proteins. GPP34 localizes to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking.	1.04526e-37
NZ_CP022961.1|WP_095566853.1|5786949_5788353_-|NAD(P)H-quinone-dehydrogenase	gnl|CDD|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NZ_CP022961.1|WP_095566864.1|5803675_5805139_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP022961.1|WP_095566859.1|5794831_5796415_-|hypothetical-protein	gnl|CDD|376584	pfam01642, MM_CoA_mutase, Methylmalonyl-CoA mutase. The enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA.	0
NZ_CP022961.1|WP_095566865.1|5805131_5805974_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143410	cd07091, ALDH_F1-2_Ald2-like, ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins. ALDH subfamily which includes the NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36), also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1), in humans, a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism. 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1), in humans, a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Also included in this subfamily is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial, homotetramers that oxidize acetaldehyde and glycolaldehyde, as well as, the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde. Also included is the AldA aldehyde dehydrogenase of Aspergillus nidulans (locus AN0554), the aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) of Saccharomyces cerevisiae, and other similar sequences.	3.08819e-37
NZ_CP022961.1|WP_095566852.1|5786271_5786943_+|DedA-family-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	8.46088e-21
NZ_CP022961.1|WP_095566855.1|5788987_5789953_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.15028e-11
NZ_CP022961.1|WP_095566862.1|5801325_5801817_+|8-oxo-dGTP-diphosphatase	gnl|CDD|239519	cd03427, MTH1, MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the incorporation of such oxygen radicals during replication. This is an important step in the repair mechanism in genomic and mitochondrial DNA. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for activity, and contain the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as a metal binding and catalytic site. MTH1 is predominantly localized in the cytoplasm and mitochondria. Structurally, this enzyme adopts a similar fold to MutT despite low sequence similarity outside the conserved nudix motif. The most distinctive structural difference between MutT and MTH1 is the presence of a beta-hairpin, which is absent in MutT. This results in a much deeper and narrower substrate binding pocket. Mechanistically, MTH1 contains dual specificity for nucleotides that contain 2-OH-adenine bases and those that contain 8-oxo-guanine bases.	6.63455e-41

Protein sequences

>NZ_CP022961.1|WP_095566856.1|5790947_5791580_-|MBL-fold-metallo-hydrolase
MRLTKYAHACVRIEHDGGVLVVDPGMFAEPAALDGADAVLVTHEHPDHLDVDAIRAAAKRRPGLAAYGHAAVLEKLADAGVAATPVAVGDSFTAAGVPVRAYGGQHAVIHPDIPRLVNLGYLIDDRVYHPGDSFAVPADSPVDTLFAPIHAPWLKLSEAVDFVRAVAPRRAFALHDGLLNEAGLNFTNANMARLAGCEYARLEPGTVVPD
>NZ_CP022961.1|WP_095566855.1|5788987_5789953_-|GNAT-family-N-acetyltransferase
MELPAGWSTRRPRLDDVPEILDMVQASCLAATGQPEFTSFDVQEALTAPGADPERNSWLALDPAGAIAGWTYLEASDGGPEDFVEVYASPGTGEPALAPLLHRSLHRIGERAVEFGHDRMSVRAGAVPSERPWIAVLENAGFAFVQRHARMRRSLADVPAEPPAPPAGVSIRAVDPADEDDLRLVHSILETAFRDAPDHQPATYQRWRAEIAALPSVAWDEWFVAEVDGVPAGALQSADQAVEQGEGWVKRLAVLREHRRRGVGAALLRRAFAAYAGKGRTYAGLGVDLSNPTEAARLYRSVGMTAEMEADIYARTVEPAR
>NZ_CP022961.1|WP_095566854.1|5788459_5788915_+|gamma-glutamylcyclotransferase
MRLYAAYGSNLDPARMLAYCPHSPMVGTGWLEGWRLTFAGDGVLGWEGAVTTVVESPGDRVFVALYDVHPGDASQLDDIEGVTAGTYRKLHVRAVTLDGEVTAWIYVFDGYEGGLPTSWYLSEIAKAAEKAGAPDDYVAALRERPTGTATA
>NZ_CP022961.1|WP_095566853.1|5786949_5788353_-|NAD(P)H-quinone-dehydrogenase
MSQIVIIGGGPAGYEAALVAAQLDADVTVVEAEGAGGACVLSDCVPSKTFIASSEVVTGYRDTEEFGVHSDGLEAVTVDATAVYQRVKRLALAQSGDIHAKLLKAGVTYVSGTARLGEDTLGHTHRVLVTPAGGGETYPIDAGTVLVATGATPRVLPSAVPDGERILTWRQVYDLPELPERLIVVGSGVTGAEFASAYLAMGVDVTLVSSRDRVMPHEDADAAMAIEQVFRSRGMTILNNCRANAVRRVGDRVEAELSDGQLITGSHALITVGSVPNTGNLGLTEYGVQVARGGYVTVDRVSRTNVPGIYAAGDCTGVLALASVAAMQGRIAMWHAMGEAVRPLRLRTVAANAFTDPELATVGVSQNEVDSGRTPARQVMLPLAGNPRAKMADLSDGFVKLFCRPASGHVIGGVVVAPRASELILPITMAVENNLTVDQLAQTITIYPSLSGSIAEAARQLMLHGLE
>NZ_CP022961.1|WP_095566852.1|5786271_5786943_+|DedA-family-protein
MTELLTTVTAPVYAYLCLLALLAADAFVPIVPTQAVMITAGALTVYGQLSLPVTIGVGALGVLTGDLSCYLLGRLRPRGAVRHVPRHARRGRIARLAGNLRRPGPLALLLCRFLPGGRMTACFHAGRLRYPYRRFLAYEGLAALGWSGYGGLVGHLGGSALAGSGWWLALIAALAASAFGLLGWVLSRLGAARLARLAEEAAAADPLGGGDPEVGAVASGPTS
>NZ_CP022961.1|WP_095566851.1|5782514_5784596_+|ABC-transporter-ATP-binding-protein
MTETTKPAGPPPARTPAAGGPAAGGPARRGAGGGPPWMSAGMPAEKSMNFGPSARRLLGRLRPHRGQLVAVITLAVLSITASVMGPKILGRATDLIFAGVLGKLFPAGMTHEQAVAAVRASGNGNMADMLDRMAVVPGQGIDFAALRTVLLVVLALYVVASLLMWLQGYLLNGLVQATILRLRADVEDKLNRLPLPYFDRQPRGELLSRVTNDIDNISQTLSQTLSQLLTSLLTVVGVLAMMVVISPLLAVVALVAIPLSVLVTRQIAKRSQRQFVAQWTHTGALNAQIEEAYTGHELVKVFGRQREVKATFAEKNEELYRASFGAQFVSGIIMPSMMFIGNLSYVAIAVVGGLRVASGTMSLGDVQAFIQYSRQFTQPLTQVASMANLLQSGVASAERVFEVLDAPEQSPDPASPARVDQRRGRVEFEHVSFRYEPDNPLIDDLSLTAEPGHTVAIVGPTGAGKTTLVNLIMRFYELDAGRITLDGVDITTMRRDELRGGIGMVLQDAWLFGGTIRDNIAYGNPDASQEQLLDAARATFVDRFVRSLPDGYDTVIDEEGSNVSAGERQLITIARAFLSDPSLLILDEATSSVDTRTEVLLQRAMAALRAERTSFVIAHRLSTIRDADLILVMEHGQIVEQGTHDQLLAAEGAYARLYQAQFSAAAVDLDAGPEAGAAPVPVGAGPRPRTPAP
>NZ_CP022961.1|WP_095566850.1|5780752_5782486_+|ABC-transporter-ATP-binding-protein
MLIRILREHLRPYTAALTGVVLLQLVGTMASLYLPRLNADIIDRGVARGDTGYILTTGGWMLLVSSLQIACSITAVYLGARTAMGFGRDVRAALFDRVGTFSAREVAQFGAPSLITRNTNDVQQVQMLVLMSCTMMVVAPIMCVGGVVMALREDVGLSWLMLVSVPVLVVAIGLIIRRMVPQFRLMQTRIDTINRVLREQISGIRVVRAFVREPYETRRFAVANEDLTQTALRTGRLMAMIFPVVMLVLNLSSVAVLWVGASRVDAGKIQIGALTAFLTYLMMILMSVMMATFMFMMVPRATVCADRIAEVLDVESSVRPPARPVTEVSTHGELELRDVSFQYPGAAAPVLRNVSFRATAGRTTAIIGSTGAGKTTLVSLVPRLFDATGGTVLVDGVDVQDLDPDLLWSRIGLVPQRPYLFSGTVASNLRYGRPDATDEQLWTALEIAQARDFVTEMPGGLEAPIAQGGTNVSGGQRQRIAIARALVRDPEIYLFDDSFSALDLGTDARLRAALRPITRDAAVVIVAQRVSTIINADQIVVLDDGAVVGLGRHDELLENCPTYAEIVASQQTTAALA
>NZ_CP022961.1|WP_095566849.1|5780261_5780759_+|winged-helix-turn-helix-transcriptional-regulator
MDPVRLDDIPLGRLVHVAGRLVGQRWSAHLAERHGLTPAGMQVLFALARHGEAGHREIAERCFVRPATLTGIVDTLERGGLVTRRRDPADRRTVRLALTESGDRQVRELFEMVHRRDPLTSVDADPANAAVIRRFLLELIATMSDGEDNGLSQADHQRAPGGGRC
>NZ_CP022961.1|WP_095566848.1|5778702_5780142_+|GuaB1-family-IMP-dehydrogenase-related-protein
MRFLSGAAPAHDLTYSDVFMAPTRSDVGSRLDVDLSTADGTGTTIPLVVANMTAVAGRRMAETTARRGGLTVLPQDIPLEVVTGVIAWVKNRHLVHDTAITLGPADTVGDAIHLLPKRSHGAVVVVDAQERPLGVVTEADTEGEDRFTQLHHVMSTELHTVPAEADPRTGFDLLSAGRRRLAPVVDREGRLVGVLTRQGALRATLYRPALDAHRRLRVAAAIGINGDVAGKAAALFAAGVDTLVVDTAHGHQERMLAALRAVRKLDPPVPVAAGNVVTAAGVRDLVEAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAQAGRLGRHVWADGGVRHPRDVALALAAGAANVMIGSWFAGTYESPGDLYVDPDGRRYKESFGMASARAVSARTGEDSPFDRARKAVFEEGISSARMHLDPVRPGVEDLIDEIVAGVRSACTYAGASSLPEFRERALIGVQSAAGYTEGMPIPTSW
>NZ_CP022961.1|WP_095566847.1|5776937_5778692_+|ATP-grasp-domain-containing-protein
MRKVLIANRGEIAVRVIRACRDAGLASVAVYADSDRDALHATLADEAYALGGDSAADTYLRIDKLVEVAARAGADAVHPGYGFLSENADFAQAVLDAGLTWIGPTPQAIRDLGDKVTARHIAQRAGAPLVPGTSEPVGGPDEVLAFAVDHGLPVAIKAAFGGGGRGLKVARTMDEIPALFESATREAVAAFGRGECFVERYLDRPRHVEAQVLADRHGNVVVVGTRDCSLQRRHQKLVEEAPAPFLTDAQRTQIHASAKAICREAGYHGAGTVEYLVGADGTISFLEVNTRLQVEHPVTEETAGIDLVREQFRIADGEKLRLTADPAPRGHSIEFRINGEDPGRGFLPAPGTVTALRLPTGPGVRVDAGIRAGDVIGGNFDSLLAKVVITGETRAEAIERARRALDEMVVDGMATALPFHRLVVRDPAFTAEPFTVHTRWIETGFDNTVPPFDAAAAAAAPAAAERETVVVEVGGKRLEVTLPAGLGAGTAAPAPAARRPARRGGGSAAGTAAGGDALTSPMQGTIVKIAVADGDTVAEGDLVVVLEAMKMEQPLHAHKGGVVTGLAAEVGAVISAGATICTLV
>NZ_CP022961.1|WP_095566858.1|5792928_5794188_-|amidohydrolase
MTSALTLPSSSPLVSSWPELPAGAQPLPLDLDQLLALRVPDLVATRRFIHAHPELSGQEFETAALIARELAQAGLSPRLLPKGNGVICDIDGRPDGPVVALRADIDALPLSDAKDVPYRSTVEGVCHACGHDVHTTVLLGVGLLLARLAERGELPGRVRLIFQPAEEILPCGSLEVIEAGGLQDVSQIFAVHCDPSLPVGRVGLRVGPITAAADNVTVKLSGPGGHTARPHLTVDLVDALGRLVTAVPALVGRRVPANSGLLLVFGQATAGTRYNVIPTEAVASGTLRVLDRDTWDQAPKIVAQVVRDVIAPTGATVDIEYLRGRPPVINDARAIQVLTAATAAALGEGGIAETPQSMGGEDFSWYLEYVPGALARLGVGRTTANADLHRATFDVDEQAIPAGVRLLVYTALKAMAAPI
>NZ_CP022961.1|WP_095566859.1|5794831_5796415_-|hypothetical-protein
MSERPLSESGFPVEPVYDADDVSPGLPERLGRPGEFPYTRGVYPTMYTSRPWTMRQYAGFGTAAESNARYHQLLRAGTMGLSVAFDLPTQMGYDSDDPIAHGEVGKVGVAIDSIEDMRRLFDGIPLDQVSTSMTINAPGSVLLLLYQLVAEESGAPGGALKGTIQNDILKEYIARGTYIFPPKPSLRLVADTFAYCRKEVPKWNTISISGYHMAEAGATPVQEIAFTLANGVEYVRAALAAGLAVDDFAPRLSFFFVARTTLLEEVAKFRAARRIWAHLMRDEFGATDPKSWMLRFHTQTAGVQLTAQQPEVNLVRVAVQGLGAVFGGTQSLHTNSFDEAIALPTEKAARLALRTQQVLAYETGLTATVDPFAGSYVVEAMTDEIEAGVRELMGRVAGYGSAVDAIEAGFQKREIETSAYRIAQEIDSGSRVVVGLNRFAVDEEEPYEPLRVDPTIEAAQADRLARLRAERDAEAVGRALAELRAAAGGTDNVLYPMREALRARATVGEVCGALRETWGTYRPSDRF
>NZ_CP022961.1|WP_095566860.1|5796619_5798602_+|protein-kinase
MTQIPTWNSPSVNPLSGRTAPGTMIGGRYTLRAAVGHGGMGTVWRAADTLLRRDVAVKEVVLPPGLAPSDRDAMYERTLREARAAAALQHPAVVQVYDVVHESGRPWIVMELLDARSLADMVIEDGPLAPRAVAKIGIALLGALEVAHAIGVLHRDVKPANVLICSDGRCVLTDFGVARMPTDVQLTTPGMVLGSPHFISPERAMGLKFGPPSDLFSLGVTLYTAVEGRPPFDKGDPIETMHAVVEEPPAPPVRCGPLSRVLFGLLEKAPERRLDVKAARGMLRDLLSGPLASKAAGQSVTDPYAVVPSTVAAAQPPATQPQPSGQIGGRAMLAPGESLTDRLAALRQESATRAGQPAWDQPTGLAGGPPPMNSGWSAGAGPADHTAPIATPVGWGPAGGAADRTAVGGQPPGGPVWVSGGNQAGPDGHWGTGAGTPGGKPGGPLNQAGAALRRSGAQLAGTVRGWPRRIQLAAAGGVAVVLLVGIVALWPDGDKATRTPQASGTTPAAQPAVPTQQYQDRGLSVNVPEGWTRTAAGVWVDYTDPEDKGRKVRILVEDFKNVTAMRWAEVAENNLKNPKSKSCPKPYTRVDLSEVELAGQTAAQLEYTCGEGDGERHGVWRGMAINDKIYSFYLTTTDANFAESKPIFDEMVRSFELDNG
>NZ_CP022961.1|WP_095566861.1|5798678_5800388_+|phosphomannomutase
MTAETHELDELREQATAWLAEDPDPAGRAELRRLVAALPGSRAELADRFAGPLTFGTAGLRGPLRAGPNGMNLTVVTRAAAGLVGWLAGHGAGGPLVIGYDARHGSREFAERTARVATGAGRAALLLPRPLPTPVLAYAVRALHGSAGVMVTASHNPPRDNGYKVYLGAELGGSRGAGAQIVPPVDAEIEAAIRAVGPLAEVPLGGPGEVLDERVVTNYVELAAAVVAPGGPRELAVAYTPLHGVGGPVLAAAFRAAGFGAPAVVAEQAEPDPEFPTVAFPNPEEPGATDLLVALAGATGADIAIANDPDADRCAVAIPVPDGPADAPAGDAPAPRRWRMLRGDEVGALLADHLMRRGNRGLYATTIVSSALLRAICTGRDLPYDETLTGFKWIVRAGGAAAAPLVYGYEEALGYCVAPDLVRDKDGITAALLVAELAAGLRAEGRGLADRLDELAAEFGVHQTDQLSIRVDDLREIADMMARLRAATPAGLLGEPITAVEDLLPGADVLIMRTPTARVVVRPSGTEPKLKAYLEVVAPVVDGDVPAARSRAVAALGRLRADVAAALRR
>NZ_CP022961.1|WP_095568113.1|5800468_5801149_-|GPP34-family-phosphoprotein
MTTTALAEELLLLAYDDKSGKALGSRIGLDLGMAAAVLVDLALANRIAFDDGSIVVTDPTPTGEPIADQVLARVAADTPHTPASWVQRLRHGLRDRALADLCGRGVMRDVDETAMGGFVHVHRYPAVDPSVEAGIRGRLADALTGSATPDERTAALATLVAAIRMEPRLGLAGREAAEVRQRLAEIGAGAGFGGGGSLDDSNVRPSVALVVEALTRAIDAALGTRA
>NZ_CP022961.1|WP_095566862.1|5801325_5801817_+|8-oxo-dGTP-diphosphatase
MRAIIATLGYVLSGDRRQVLLLRRDRRPDDLHWGYHNGLGGKLEPGEDVVAGMRREIREESGLEARTVELAGTISWPGFGRDGENWFGFLFRIPDWSGEPYRECPEGTLVWTDLADVLAGRVSMWPSDRHFLPLVFAERPAVFHGVMPFADRVALDWRYSLTD
>NZ_CP022961.1|WP_095566863.1|5801920_5802553_-|uracil-phosphoribosyltransferase
MDVLVVDHPLAQSRLTAMRDARTDSAAFRAALHELTTMLVYEAARSFPLERYPVSTPVAPTDGFRLANPPLLVPVLRAGLGMADAALGLLPESSMGFVGLARDEETFEPRAYMESLPVELAGIPVLVLDPMVATGGSLEHCCRLLAERGCTEITVLCVLAAPAGIERLERSGLPLRMVTAAVDERLNDRRFIVPGLGDAGDRQFGGMPRF
>NZ_CP022961.1|WP_095568114.1|5802683_5803670_+|deoxyribose-phosphate-aldolase
MTATTISGRADLSELGRSEVTLRTFLHGLPGVDQVGAEARAAMLGTRSIKTSAKAWAIDLAIRMVDLTTLEGADTPGKVRALSAKALRPDPADPTCPHVGAVCVYPAMVRYAAEVLRGGGTPAPGGEPGVHLASVATAFPSGQAPLAVKIADTEAAVAAGADEIDMVINRGAFLAGRYGEVYEEIVATRQACGDAHLKVILETGELATYDNVRRASWLAMLAGGDFIKTSTGKVPVAATPPVTLIMLEAVRDFRAATGRQVGVKPAGGIRTTKDAIKYLVMVNETAGADWLHPDWFRFGASSLLNDLLMQRTKLTTGVYAGPDYFTLD
>NZ_CP022961.1|WP_095566864.1|5803675_5805139_+|aldehyde-dehydrogenase-family-protein
MGPFEYAPAPESRAIVDLKPSYGLFVDGEFVDPGDGGGFKSINPASEEVLAEVAEAGPRDVDRAVAAARTAYERVWGPMPGRDRAKYLYRIARIIQERSRELAVLESLDNGKPIRESRDVDLPLVAAHFFYYAGWADKLRYAGFGRGPAGRDGDADPRPLGVAGQVIPWNFPLLMLAWKIAPALAAGNTVVLKPAETTPLSALLFAEICQQADLPPGVVNIVTGAGDTGRALVEHAGIDKVAFTGSTEVGRQIARSVAGTGRKLTLELGGKAANIVFDDAPVDQAVEGIVNGIFFNQGHVCCAGSRLLVQESVYDEVLGALKRRMTRLRVGDPLDKNTDIGAINSAAQLDRIRELSQVGAAEGAQRWSPPCELPDRGFWFAPTVFTGVTQAHRIAREEIFGPVLSVLTFRTPAEAIEKANNTPYGLSAGIWTDKGSRILWLADRLRAGVVWANTFNKFDPTSPFGGYKESGYGREGGRHGLEAYLDV
>NZ_CP022961.1|WP_095566865.1|5805131_5805974_+|aldehyde-dehydrogenase-family-protein
MSKGSPSPARVAVRKTYKLFIGGKFPRSESGRSYLVADTNVALASRKDVRDAVLAARAAVKGWSGATAYNRGQILYRVAEMLEGRRDQFVGLGVPADEVDAAIDRWVWYAGWSDKLAQVYGGANPVAGPYFNLSAPEPSGVVGVVAPAEPSLLGLVSVIAPAIVAGNTVVVLVGESAPLPAVTLAEVLATSDLPGGVVNLLTGRPAETAPWLAGHMDVNALDLAGAVDPDLAADLEIRAAENLKRVLRPVPAGHDWYADPGITRMTALLETKTVWHPKGQ

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022961_20	20.1|3958948|16|NZ_CP022961|CRISPRCasFinder	3958948-3958963	16	NZ_CP022961.1	1181138-1181153	0	1.0
NZ_CP022961_20	20.1|3958948|16|NZ_CP022961|CRISPRCasFinder	3958948-3958963	16	NZ_CP022961.1	1933825-1933840	0	1.0
NZ_CP022961_25	25.1|4922051|33|NZ_CP022961|CRISPRCasFinder	4922051-4922083	33	NZ_CP022961.1	4922141-4922173	0	1.0
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP022961.1	4922108-4922131	1	0.958
NZ_CP022961_15	15.2|3714985|26|NZ_CP022961|CRISPRCasFinder	3714985-3715010	26	NZ_CP022961.1	3417691-3417716	2	0.923

1. spacer 20.1|3958948|16|NZ_CP022961|CRISPRCasFinder matches to position: 1181138-1181153, mismatch: 0, identity: 1.0

ccgtcagcgcggcggt	CRISPR spacer
ccgtcagcgcggcggt	Protospacer
****************

2. spacer 20.1|3958948|16|NZ_CP022961|CRISPRCasFinder matches to position: 1933825-1933840, mismatch: 0, identity: 1.0

ccgtcagcgcggcggt	CRISPR spacer
ccgtcagcgcggcggt	Protospacer
****************

3. spacer 25.1|4922051|33|NZ_CP022961|CRISPRCasFinder matches to position: 4922141-4922173, mismatch: 0, identity: 1.0

cgccgcgctcgtgccggtccgggtggacgtggc	CRISPR spacer
cgccgcgctcgtgccggtccgggtggacgtggc	Protospacer
*********************************

4. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to position: 4922108-4922131, mismatch: 1, identity: 0.958

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcgtcgccttgcgggccggcgc	Protospacer
*****.******************

5. spacer 15.2|3714985|26|NZ_CP022961|CRISPRCasFinder matches to position: 3417691-3417716, mismatch: 2, identity: 0.923

gtagcgggccggccccggtagcgggc	CRISPR spacer
gtagcgggccgggccgggtagcgggc	Protospacer
************ ** **********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022961_24	24.3|4921880|21|NZ_CP022961|CRISPRCasFinder	4921880-4921900	21	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	1287978-1287998	1	0.952
NZ_CP022961_24	24.3|4921880|21|NZ_CP022961|CRISPRCasFinder	4921880-4921900	21	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	1123153-1123173	1	0.952
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP015091	Pelagibaca abyssi strain JLT2014 plasmid pPABY1, complete sequence	102525-102548	2	0.917
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP045345	Labrenzia sp. THAF187b plasmid pTHAF187b_a, complete sequence	359278-359301	2	0.917
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP045329	Labrenzia sp. THAF191b plasmid pTHAF191b_a, complete sequence	46320-46343	2	0.917
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP045335	Labrenzia sp. THAF191a plasmid pTHAF191a_b, complete sequence	336962-336985	2	0.917
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP025548	Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence	42954-42977	2	0.917
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NC_010408	Clavibacter michiganensis subsp. sepedonicus plasmid pCSL1, complete sequence	56995-57018	3	0.875
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_LR134459	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence	4715-4738	3	0.875
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP015811	Microbacterium chocolatum strain SIT 101 plasmid 1, complete sequence	6700-6723	3	0.875
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP015812	Microbacterium chocolatum strain SIT 101 plasmid 2, complete sequence	1623-1646	3	0.875
NZ_CP022961_24	24.2|4921832|24|NZ_CP022961|CRISPRCasFinder	4921832-4921855	24	NZ_CP015041	Rhodovulum sp. P5 plasmid pRGUI02, complete sequence	10991-11014	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1269266-1269289	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1271303-1271326	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	1468259-1468282	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	165614-165637	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	1423493-1423516	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	189859-189882	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	1423467-1423490	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	1423500-1423523	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	261350-261373	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP021765	Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence	1380053-1380076	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	1342116-1342139	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	1287735-1287758	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NC_009621	Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence	223229-223252	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	1025289-1025312	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	49321-49344	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	857369-857392	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP015065	Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence	148475-148498	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NC_011143	Phenylobacterium zucineum HLK1 plasmid, complete sequence	237933-237956	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP015063	Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence	171437-171460	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	1025397-1025420	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	103246-103269	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP018865	Arthrobacter crystallopoietes strain DSM 20117 plasmid pLDW-10, complete sequence	187746-187769	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	466856-466879	3	0.875
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1901215-1901238	3	0.875
NZ_CP022961_15	15.1|3714933|27|NZ_CP022961|CRISPRCasFinder	3714933-3714959	27	NC_048003	Pseudomonas phage phCDa, complete genome	53133-53159	4	0.852
NZ_CP022961_15	15.2|3714985|26|NZ_CP022961|CRISPRCasFinder	3714985-3715010	26	NZ_CP012383	Streptomyces ambofaciens ATCC 23877 plasmid pSAM1, complete sequence	1974-1999	4	0.846
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	CP047034	Rhodobacter sphaeroides strain DSM 158 plasmid pB, complete sequence	27630-27657	4	0.857
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP015291	Rhodobacter sphaeroides strain MBTLJ-20 plasmid c, complete sequence	41972-41999	4	0.857
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP047040	Rhodobacter sphaeroides strain 2.4.1 substr. H2 plasmid pB, complete sequence	27603-27630	4	0.857
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP051471	Rhodobacter sphaeroides strain CH10 plasmid pRspCH10B, complete sequence	64102-64129	4	0.857
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP030274	Rhodobacter sphaeroides 2.4.1 plasmid pB, complete sequence	85570-85597	4	0.857
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP015215	Rhodobacter sphaeroides strain MBTLJ-13 plasmid d, complete sequence	49383-49410	4	0.857
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	AY950802	Haloarcula phage SH1, complete genome	10245-10272	4	0.857
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1263154-1263177	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1263834-1263857	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1264512-1264535	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1265870-1265893	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1266552-1266575	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1267230-1267253	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1267911-1267934	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1268591-1268614	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1269945-1269968	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1270623-1270646	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1271984-1272007	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1272665-1272688	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	617488-617511	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	230056-230079	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	29336-29359	4	0.833
NZ_CP022961_26	26.1|4922198|24|NZ_CP022961|CRISPRCasFinder	4922198-4922221	24	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	498151-498174	4	0.833
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1413906-1413935	4	0.867
NZ_CP022961_3	3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400084-400116	33	NZ_CP039426	Citricoccus sp. SGAir0253 plasmid unnamed2, complete sequence	44008-44040	5	0.848
NZ_CP022961_3	3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400084-400116	33	NZ_CP039431	Citricoccus sp. SGAir0453 plasmid unnamed2, complete sequence	44008-44040	5	0.848
NZ_CP022961_7	7.12|1074827|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074827-1074859	33	NZ_CP021367	Acidovorax carolinensis strain P4 plasmid pACP4.1, complete sequence	119521-119553	5	0.848
NZ_CP022961_7	7.12|1074827|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074827-1074859	33	NZ_CP021363	Acidovorax carolinensis strain P3 plasmid pACP3.1, complete sequence	104413-104445	5	0.848
NZ_CP022961_17	17.16|3912565|31|NZ_CP022961|CRT	3912565-3912595	31	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	8596-8626	5	0.839
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1784621-1784648	5	0.821
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1842686-1842713	5	0.821
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NC_024970	Streptomyces aureofaciens strain CCM3239 plasmid pSA3239, complete sequence	118975-119002	5	0.821
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_KJ396772	Streptomyces lavendulae subsp. lavendulae strain CCM3239 plasmid pSA3239, complete sequence	118975-119002	5	0.821
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP013345	Sphingopyxis macrogoltabida strain 203N plasmid unnamed1, complete sequence	221054-221081	5	0.821
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP024986	Streptomyces lavendulae subsp. lavendulae strain CCM 3239 plasmid pSA3239, complete sequence	122075-122102	5	0.821
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP040763	Paracoccus sp. 2251 plasmid unnamed4, complete sequence	247137-247169	6	0.818
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NC_012520	Rhodococcus opacus B4 plasmid pROB01, complete sequence	244394-244426	6	0.818
NZ_CP022961_6	6.1|960055|32|NZ_CP022961|CRISPRCasFinder	960055-960086	32	NC_013858	Azospirillum sp. B510 plasmid pAB510d, complete sequence	45661-45692	6	0.812
NZ_CP022961_7	7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074949-1074981	33	MN304824	Catenulispora phage 69_17, complete genome	20459-20491	6	0.818
NZ_CP022961_7	7.17|1075132|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1075132-1075164	33	NZ_CP049908	Hymenobacter sp. HDW8 plasmid p_unnamed1, complete sequence	288826-288858	6	0.818
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_LR134459	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence	69484-69515	6	0.812
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	KX397365	Erwinia phage vB_EamM_Caitlin, complete genome	229855-229886	6	0.812
NZ_CP022961_15	15.2|3714985|26|NZ_CP022961|CRISPRCasFinder	3714985-3715010	26	NZ_CP020568	Kitasatospora aureofaciens strain DM-1 plasmid unnamed1, complete sequence	245419-245444	6	0.769
NZ_CP022961_15	15.2|3714985|26|NZ_CP022961|CRISPRCasFinder	3714985-3715010	26	NZ_CP020952	Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence	277829-277854	6	0.769
NZ_CP022961_17	17.5|3912565|32|NZ_CP022961|PILER-CR	3912565-3912596	32	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	8596-8627	6	0.812
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	1238126-1238153	6	0.786
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	31823-31850	6	0.786
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1731924-1731953	6	0.8
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	81339-81368	6	0.8
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	617212-617241	6	0.8
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NC_010627	Paraburkholderia phymatum STM815 plasmid pBPHY02, complete sequence	411944-411973	6	0.8
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP039902	Agrobacterium tumefaciens strain CFBP5877 plasmid pTiCFBP5877, complete sequence	72309-72339	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	131248-131278	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP039893	Agrobacterium tumefaciens strain CFBP5499 plasmid pTiCFBP5499, complete sequence	37108-37138	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_KY000025	Agrobacterium genomosp. 6 strain AR125 plasmid pTi_AR125, complete sequence	168733-168763	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_KY000029	Agrobacterium genomosp. 6 strain CFBP5499 plasmid pTi_CFBP5499, complete sequence	168733-168763	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP016905	Ralstonia solanacearum strain KACC 10709 plasmid unnamed1	2082684-2082714	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	1011541-1011571	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP009803	Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence	127901-127931	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP022194	Yangia pacifica strain YSBP01 plasmid unnamed4, complete sequence	20426-20456	6	0.806
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	KU963251	Gordonia phage UmaThurman, complete genome	33480-33510	6	0.806
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	946502-946534	7	0.788
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP040763	Paracoccus sp. 2251 plasmid unnamed4, complete sequence	248106-248138	7	0.788
NZ_CP022961_5	5.1|472740|28|NZ_CP022961|CRISPRCasFinder	472740-472767	28	NZ_CP021649	Acidovorax sp. T1 plasmid p1-T1, complete sequence	18705-18732	7	0.75
NZ_CP022961_6	6.1|960055|32|NZ_CP022961|CRISPRCasFinder	960055-960086	32	NZ_CP045288	Curtobacterium flaccumfaciens pv. flaccumfaciens strain P990 plasmid pCff1, complete sequence	75106-75137	7	0.781
NZ_CP022961_6	6.1|960055|32|NZ_CP022961|CRISPRCasFinder	960055-960086	32	CP041260	Curtobacterium flaccumfaciens pv. flaccumfaciens strain Cff1037 plasmid pCFF113, complete sequence	69517-69548	7	0.781
NZ_CP022961_7	7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074583-1074615	33	NC_019018	Mycobacterium marinum DL240490 plasmid pMUM003, complete sequence	87604-87636	7	0.788
NZ_CP022961_7	7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074583-1074615	33	NC_011355	Mycobacterium liflandii 128FXT plasmid pMUM002, complete sequence	34379-34411	7	0.788
NZ_CP022961_7	7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074583-1074615	33	NZ_AP017625	Mycobacterium ulcerans subsp. shinshuense strain ATCC 33728 plasmid pShTP, complete sequence	29282-29314	7	0.788
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	899754-899785	7	0.781
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	501523-501554	7	0.781
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	158779-158810	7	0.781
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_CP019037	Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence	270255-270286	7	0.781
NZ_CP022961_19	19.3|3923015|35|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923015-3923049	35	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	227862-227896	7	0.8
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NC_047816	Ralstonia phage RS-PI-1, complete genome	21073-21106	7	0.794
NZ_CP022961_21	21.1|3959380|28|NZ_CP022961|CRISPRCasFinder	3959380-3959407	28	NZ_CP045548	Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence	309455-309482	7	0.75
NZ_CP022961_22	22.1|4497892|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	4497892-4497925	34	NZ_CP004394	Celeribacter indicus strain P73 plasmid pP73A, complete sequence	57723-57756	7	0.794
NZ_CP022961_25	25.1|4922051|33|NZ_CP022961|CRISPRCasFinder	4922051-4922083	33	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	921875-921907	7	0.788
NZ_CP022961_25	25.1|4922051|33|NZ_CP022961|CRISPRCasFinder	4922051-4922083	33	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	891247-891279	7	0.788
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	4261-4290	7	0.767
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NC_015583	Novosphingobium sp. PP1Y plasmid Mpl, complete sequence	586395-586424	7	0.767
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	NZ_CP036516	Lichenihabitans psoromatis strain PAMC 29148 plasmid p_unnamed1, complete sequence	110495-110524	7	0.767
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP022991	Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence	166539-166569	7	0.774
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP035424	Leisingera sp. NJS204 plasmid unnamed7, complete sequence	17317-17347	7	0.774
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NC_018696	Paraburkholderia phenoliruptrix BR3459a plasmid pSYMBR3459, complete sequence	60112-60142	7	0.774
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	539944-539980	7	0.811
NZ_CP022961_3	3.4|399596|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399596-399628	33	JX006077	Saccharomonospora phage PIS 136, complete genome	56877-56909	8	0.758
NZ_CP022961_3	3.5|399657|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399657-399689	33	NZ_CP020716	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence	214479-214511	8	0.758
NZ_CP022961_3	3.5|399657|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399657-399689	33	NC_017791	Deinococcus gobiensis I-0 plasmid P2, complete sequence	413113-413145	8	0.758
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NC_017957	Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence	665580-665612	8	0.758
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP054621	Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence	1011157-1011189	8	0.758
NZ_CP022961_3	3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400084-400116	33	NZ_CP010408	Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence	30543-30575	8	0.758
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	MN582066	Siphoviridae sp. ctpQM7, complete genome	35404-35436	8	0.758
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	LR743523	Xylella phage Usme genome assembly, chromosome: 1	21650-21682	8	0.758
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	LR743529	Xanthomonas phage Sopo genome assembly, chromosome: 1	22081-22113	8	0.758
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	LR743528	Xanthomonas phage Tabio genome assembly, chromosome: 1	21889-21921	8	0.758
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	LR743531	Xanthomonas phage Tenjo genome assembly, chromosome: 1	21423-21455	8	0.758
NZ_CP022961_3	3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400816-400848	33	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	1237824-1237856	8	0.758
NZ_CP022961_3	3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400816-400848	33	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	1140556-1140588	8	0.758
NZ_CP022961_3	3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400816-400848	33	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	1140544-1140576	8	0.758
NZ_CP022961_6	6.1|960055|32|NZ_CP022961|CRISPRCasFinder	960055-960086	32	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	1508826-1508857	8	0.75
NZ_CP022961_7	7.10|1074705|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074705-1074737	33	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	229113-229145	8	0.758
NZ_CP022961_7	7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074949-1074981	33	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3921731-3921763	8	0.758
NZ_CP022961_7	7.19|1075254|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1075254-1075286	33	NZ_CP040722	Rhodococcus pyridinivorans strain YF3 plasmid unnamed3, complete sequence	22794-22826	8	0.758
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1291338-1291371	8	0.765
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	330109-330142	8	0.765
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP023549	Rhodobacter sp. CZR27 plasmid unnamed1, complete sequence	503499-503529	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP033321	Azospirillum brasilense strain Cd plasmid p3, complete sequence	387435-387465	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP033315	Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence	280766-280796	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP019083	Paludisphaera borealis strain PX4 plasmid PALBO1, complete sequence	1468-1498	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NC_017805	Deinococcus gobiensis I-0 plasmid P1, complete sequence	8782-8812	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP032342	Azospirillum brasilense strain MTCC4038 plasmid p3, complete sequence	431612-431642	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP015867	Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence	370486-370516	8	0.742
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	287247-287277	8	0.742
NZ_CP022961_3	3.2|399474|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399474-399506	33	NC_021321	Halovirus HRTV-8, complete genome	29549-29581	9	0.727
NZ_CP022961_3	3.7|399779|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399779-399811	33	KM378617	Vibrio phage VpKK5, complete genome	21179-21211	9	0.727
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP049908	Hymenobacter sp. HDW8 plasmid p_unnamed1, complete sequence	25448-25480	9	0.727
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP037921	Hymenobacter sp. 17J36-26 plasmid unnamed1, complete sequence	125665-125697	9	0.727
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	MH576962	Streptomyces phage Satis, complete genome	98709-98741	9	0.727
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	MK620894	Streptomyces phage Kradal, complete genome	98713-98745	9	0.727
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NZ_CP034153	Rhodococcus sp. NJ-530 plasmid unnamed1, complete sequence	50326-50358	9	0.727
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NZ_LR134451	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence	272738-272770	9	0.727
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	983184-983216	9	0.727
NZ_CP022961_3	3.25|400877|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400877-400909	33	NZ_CP018468	Xanthomonas vesicatoria strain LM159 plasmid pLM159.1, complete sequence	199548-199580	9	0.727
NZ_CP022961_6	6.1|960055|32|NZ_CP022961|CRISPRCasFinder	960055-960086	32	NC_048790	Corynebacterium phage Lederberg, complete genome	14029-14060	9	0.719
NZ_CP022961_7	7.3|1074278|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074278-1074310	33	KY798216	Mycobacterium phage Journey13, complete genome	22031-22063	9	0.727
NZ_CP022961_7	7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074583-1074615	33	NZ_CP044989	Deinococcus sp. AJ005 plasmid p380k, complete sequence	216236-216268	9	0.727
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_CP047175	Rathayibacter sp. VKM Ac-2760 plasmid unnamed2, complete sequence	65128-65159	9	0.719
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_LR134460	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 18, complete sequence	178083-178114	9	0.719
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	MT310875	Microbacterium phage Ashton, complete genome	18844-18875	9	0.719
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NC_048761	Microbacterium phage Akoni, complete genome	18628-18659	9	0.719
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_CP033583	Streptomyces sp. ADI95-16 plasmid pADI95-16b, complete sequence	128625-128658	9	0.735
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_CP011667	Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence	113721-113754	9	0.735
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_CP015368	Methylobacterium phyllosphaerae strain CBMB27 plasmid CBMB27-p1, complete sequence	125493-125526	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1113425-1113458	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	113237-113270	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1351418-1351451	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	953547-953580	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	610404-610437	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP024940	Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence	193408-193441	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	MH779501	Gordonia phage Emianna, complete genome	25585-25618	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	MH727547	Gordonia phage Foxboro, complete genome	26091-26124	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	MH779510	Gordonia phage Kurt, complete genome	25600-25633	9	0.735
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	MH779508	Gordonia phage Jifall16, complete genome	25239-25272	9	0.735
NZ_CP022961_27	27.1|5008568|30|NZ_CP022961|CRISPRCasFinder	5008568-5008597	30	LR606148	Rhizobium sp. Q54 genome assembly, plasmid: 5	181026-181055	9	0.7
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	418033-418063	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	470291-470321	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP013632	Rhizobium sp. N324 plasmid pRspN324b, complete sequence	360767-360797	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	MT740729	Ralstonia phage Bakoly, complete genome	5799-5829	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP029358	Azospirillum sp. CFH 70021 plasmid unnamed3	172042-172072	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP014797	Salipiger profundus strain JLT2016 plasmid pTPRO1, complete sequence	157723-157753	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	MT740747	Ralstonia phage Simangalove, complete genome	38966-38996	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	MT740744	Ralstonia phage Jenny, complete genome	38093-38123	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	MT740735	Ralstonia phage Elie, complete genome	38949-38979	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	MT740746	Ralstonia phage Sarlave, complete genome	4559-4589	9	0.71
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	MT740725	Ralstonia phage Adzire, complete genome	38816-38846	9	0.71
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	JN699011	Mycobacterium phage Stinger, complete genome	31538-31574	9	0.757
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	NC_011044	Mycobacterium phage Nigel, complete genome	31850-31886	9	0.757
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	995095-995131	9	0.757
NZ_CP022961_3	3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	399962-399994	33	NZ_CP027299	Streptomyces sp. SGAir0924 plasmid unnamed_5	190608-190640	10	0.697
NZ_CP022961_3	3.16|400328|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400328-400360	33	NZ_CP027299	Streptomyces sp. SGAir0924 plasmid unnamed_5	179657-179689	10	0.697
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NZ_CP044329	Methylocystis rosea strain BRCS1 plasmid unnamed1, complete sequence	99624-99656	10	0.697
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NZ_CP015231	Epibacterium mobile F1926 plasmid unnamed1, complete sequence	370526-370558	10	0.697
NZ_CP022961_3	3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	400572-400604	33	NZ_CP041975	Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP 16207 plasmid unnamed2, complete sequence	15642-15674	10	0.697
NZ_CP022961_7	7.3|1074278|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074278-1074310	33	NZ_LN890657	Candidatus Promineofilum breve strain Cfx-K plasmid III, complete sequence	28180-28212	10	0.697
NZ_CP022961_7	7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR	1074949-1074981	33	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	988763-988795	10	0.697
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NC_015728	Roseobacter litoralis Och 149 plasmid pRLO149_83, complete sequence	35488-35519	10	0.688
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NZ_CP048426	Rhizobium daejeonense strain KACC 13094 plasmid unnamed3, complete sequence	143276-143307	10	0.688
NZ_CP022961_8	8.1|1402159|32|NZ_CP022961|CRISPRCasFinder	1402159-1402190	32	NC_019959	Mycobacterium sp. JS623 plasmid pMYCSM03, complete sequence	105350-105381	10	0.688
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_CP022541	Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence	216769-216802	10	0.706
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_CP003988	Streptomyces sp. 769 plasmid pSGZL, complete sequence	160872-160905	10	0.706
NZ_CP022961_17	17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT	3912436-3912469	34	NZ_LR134460	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 18, complete sequence	349619-349652	10	0.706
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP044544	Bradyrhizobium betae strain PL7HG1 plasmid pBbPL7HG1, complete sequence	43699-43732	10	0.706
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NZ_CP013586	Rhizobium phaseoli strain N161 plasmid pRphaN161a, complete sequence	120831-120861	10	0.677
NZ_CP022961_28	28.2|5238997|31|NZ_CP022961|CRISPRCasFinder	5238997-5239027	31	NC_031059	Rhodovulum phage vB_RhkS_P1, complete genome	6591-6621	10	0.677
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	NC_006571	Streptomyces albulus plasmid pNO33 DNA, complete sequence	6518-6554	10	0.73
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP047181	Rathayibacter festucae strain VKM Ac-2802 plasmid unnamed1, complete sequence	4611-4644	11	0.676
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP047184	Rathayibacter sp. VKM Ac-2801 plasmid unnamed, complete sequence	11220-11253	11	0.676
NZ_CP022961_19	19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder	3923148-3923181	34	NZ_CP047177	Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence	115634-115667	11	0.676
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	MN234171	Mycobacterium phage Magpie, complete genome	32804-32840	11	0.703
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	NC_042034	Mycobacterium phage ChrisnMich, complete sequence	31926-31962	11	0.703
NZ_CP022961_29	29.1|5330675|37|NZ_CP022961|CRISPRCasFinder	5330675-5330711	37	KF493881	Mycobacterium phage JAMaL, complete genome	33145-33181	11	0.703

1. spacer 24.3|4921880|21|NZ_CP022961|CRISPRCasFinder matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 1, identity: 0.952

ggcggacttggtcgccgcgct	CRISPR spacer
ggcggacgtggtcgccgcgct	Protospacer
******* *************

2. spacer 24.3|4921880|21|NZ_CP022961|CRISPRCasFinder matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 1, identity: 0.952

ggcggacttggtcgccgcgct	CRISPR spacer
ggcggacgtggtcgccgcgct	Protospacer
******* *************

3. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015091 (Pelagibaca abyssi strain JLT2014 plasmid pPABY1, complete sequence) position: , mismatch: 2, identity: 0.917

cggcgcccgcttggccgccgtcgt	CRISPR spacer
cggcgcccggctggccgccgtcgt	Protospacer
********* .*************

4. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP045345 (Labrenzia sp. THAF187b plasmid pTHAF187b_a, complete sequence) position: , mismatch: 2, identity: 0.917

cggcgcccgcttggccgcc-gtcgt	CRISPR spacer
cggcgcccgcttggccgccaatcg-	Protospacer
******************* .*** 

5. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP045329 (Labrenzia sp. THAF191b plasmid pTHAF191b_a, complete sequence) position: , mismatch: 2, identity: 0.917

cggcgcccgcttggccgcc-gtcgt	CRISPR spacer
cggcgcccgcttggccgccaatcg-	Protospacer
******************* .*** 

6. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP045335 (Labrenzia sp. THAF191a plasmid pTHAF191a_b, complete sequence) position: , mismatch: 2, identity: 0.917

cggcgcccgcttggccgcc-gtcgt	CRISPR spacer
cggcgcccgcttggccgccaatcg-	Protospacer
******************* .*** 

7. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP025548 (Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.917

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcgccgccgtgctggccggcgc	Protospacer
********** *** *********

8. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NC_010408 (Clavibacter michiganensis subsp. sepedonicus plasmid pCSL1, complete sequence) position: , mismatch: 3, identity: 0.875

cggcgcccgcttggccgccgtcgt	CRISPR spacer
cggcgcccgcttcgccggcgtcgg	Protospacer
************ **** ***** 

9. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_LR134459 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence) position: , mismatch: 3, identity: 0.875

cggcgcccgcttggccgccgtcgt	CRISPR spacer
cggcgcccgctgggccgcggtcgg	Protospacer
*********** ****** **** 

10. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015811 (Microbacterium chocolatum strain SIT 101 plasmid 1, complete sequence) position: , mismatch: 3, identity: 0.875

cggcgcccgcttggccgccgtcgt	CRISPR spacer
cggcacccgctgggccgccgtcgg	Protospacer
****.****** *********** 

11. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015812 (Microbacterium chocolatum strain SIT 101 plasmid 2, complete sequence) position: , mismatch: 3, identity: 0.875

cggcgcccgcttggccgccgtcgt	CRISPR spacer
cggcacccgctgggccgccgtcgg	Protospacer
****.****** *********** 

12. spacer 24.2|4921832|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015041 (Rhodovulum sp. P5 plasmid pRGUI02, complete sequence) position: , mismatch: 3, identity: 0.875

cggcgcccgcttggccgccgtcgt	CRISPR spacer
cggcgcccgcatggccgcggtcga	Protospacer
********** ******* **** 

13. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggcca	Protospacer
***** ****************  

14. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggcca	Protospacer
***** ****************  

15. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

16. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
gatcgccgccttgagggccggcgt	Protospacer
*.*********** *********.

17. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

18. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
gctcgccgccttgcgtgccggcgt	Protospacer
* ************* *******.

19. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

20. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

21. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgtcgccgccttcctggccggcgc	Protospacer
 *********** * *********

22. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP021765 (Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

23. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

24. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

25. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NC_009621 (Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
gctcgccgccttccgggccggcga	Protospacer
* ********** ********** 

26. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

27. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccctgcgggccggcgc	Protospacer
 *.*******.*************

28. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
gctcgccgccttgcgtgccggcgt	Protospacer
* ************* *******.

29. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015065 (Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttccgggccggcgc	Protospacer
 *.********* ***********

30. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NC_011143 (Phenylobacterium zucineum HLK1 plasmid, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cggcgccgccttgcgagccggcgc	Protospacer
 * ************.********

31. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015063 (Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttccgggccggcgc	Protospacer
 *.********* ***********

32. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgccgccgccttgcgggcccgcgc	Protospacer
 *.**************** ****

33. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
gcccgccgccttgccggccggcgc	Protospacer
* .*********** *********

34. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP018865 (Arthrobacter crystallopoietes strain DSM 20117 plasmid pLDW-10, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcgccgctttgcaggccggcgt	Protospacer
*********.****.********.

35. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
cgtcgccgccttcctggccggcgc	Protospacer
 *********** * *********

36. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 3, identity: 0.875

ggtcgccgccttgcgggccggcgc	CRISPR spacer
gatcgccgccttgagggccggcgt	Protospacer
*.*********** *********.

37. spacer 15.1|3714933|27|NZ_CP022961|CRISPRCasFinder matches to NC_048003 (Pseudomonas phage phCDa, complete genome) position: , mismatch: 4, identity: 0.852

gcgctgtccgtgcccccgcgtccgcat	CRISPR spacer
tcgatgtcagtgcccccgcgtccgcgt	Protospacer
 ** **** ****************.*

38. spacer 15.2|3714985|26|NZ_CP022961|CRISPRCasFinder matches to NZ_CP012383 (Streptomyces ambofaciens ATCC 23877 plasmid pSAM1, complete sequence) position: , mismatch: 4, identity: 0.846

gtagcgggccggccccggtagcgggc	CRISPR spacer
ggggcgggcagggcccggtagcgggc	Protospacer
* .****** ** *************

39. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to CP047034 (Rhodobacter sphaeroides strain DSM 158 plasmid pB, complete sequence) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgcgccggagggggccggcgacccggcg	Protospacer
**  ******* ************** *

40. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015291 (Rhodobacter sphaeroides strain MBTLJ-20 plasmid c, complete sequence) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgcgccggagggggccggcgacccggcg	Protospacer
**  ******* ************** *

41. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP047040 (Rhodobacter sphaeroides strain 2.4.1 substr. H2 plasmid pB, complete sequence) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgcgccggagggggccggcgacccggcg	Protospacer
**  ******* ************** *

42. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP051471 (Rhodobacter sphaeroides strain CH10 plasmid pRspCH10B, complete sequence) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgcgccggagggggccggcgacccggcg	Protospacer
**  ******* ************** *

43. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP030274 (Rhodobacter sphaeroides 2.4.1 plasmid pB, complete sequence) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgcgccggagggggccggcgacccggcg	Protospacer
**  ******* ************** *

44. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015215 (Rhodobacter sphaeroides strain MBTLJ-13 plasmid d, complete sequence) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgcgccggagggggccggcgacccggcg	Protospacer
**  ******* ************** *

45. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to AY950802 (Haloarcula phage SH1, complete genome) position: , mismatch: 4, identity: 0.857

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgacccggagccggacggcgacccccag	Protospacer
********** *** *********  **

46. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

47. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

48. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

49. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

50. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

51. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

52. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

53. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

54. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

55. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

56. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

57. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ggtcggcgccttgcgggccggtca	Protospacer
***** ***************.  

58. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ccacgacgccttgcgggccggcgc	Protospacer
   ** ******************

59. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
caccgccgccctgcgggccggcgc	Protospacer
 ..*******.*************

60. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
ccacgacgccttgcgggccggcgc	Protospacer
   ** ******************

61. spacer 26.1|4922198|24|NZ_CP022961|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 4, identity: 0.833

ggtcgccgccttgcgggccggcgc	CRISPR spacer
caccgccgccctgcgggccggcgc	Protospacer
 ..*******.*************

62. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 4, identity: 0.867

accggcacggcgg---tccggggcgggcacggc	CRISPR spacer
---ggcacggcggcgctccggggcgggcagggc	Protospacer
   **********   ************* ***

63. spacer 3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039426 (Citricoccus sp. SGAir0253 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.848

gcgggccatcaccccggtcgccggcttgcggcg-	CRISPR spacer
ccgggccatcgccccggtcgccggc-tacgacgc	Protospacer
 *********.************** *.**.** 

64. spacer 3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039431 (Citricoccus sp. SGAir0453 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.848

gcgggccatcaccccggtcgccggcttgcggcg-	CRISPR spacer
ccgggccatcgccccggtcgccggc-tacgacgc	Protospacer
 *********.************** *.**.** 

65. spacer 7.12|1074827|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021367 (Acidovorax carolinensis strain P4 plasmid pACP4.1, complete sequence) position: , mismatch: 5, identity: 0.848

tccgtgatggtccgctcggggatgccgcgcggg	CRISPR spacer
tcttcgatggtccgctcgccgatgccgcgcggg	Protospacer
**. .*************  *************

66. spacer 7.12|1074827|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021363 (Acidovorax carolinensis strain P3 plasmid pACP3.1, complete sequence) position: , mismatch: 5, identity: 0.848

tccgtgatggtccgctcggggatgccgcgcggg	CRISPR spacer
tcttcgatggtccgctcgccgatgccgcgcggg	Protospacer
**. .*************  *************

67. spacer 17.16|3912565|31|NZ_CP022961|CRT matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.839

ccaggctgggcgcccagcctggggcgacggg	CRISPR spacer
ccgtgctgggcgaccagccgggggcgacgga	Protospacer
**. ******** ****** **********.

68. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 5, identity: 0.821

cgacccggaggcggccggcgacccggag	CRISPR spacer
ggacccggaggcggccggcgatggcgag	Protospacer
 ********************.   ***

69. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.821

cgacccggaggcggccggcgacccggag	CRISPR spacer
ggacccggaggcggccggcgatggcgag	Protospacer
 ********************.   ***

70. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NC_024970 (Streptomyces aureofaciens strain CCM3239 plasmid pSA3239, complete sequence) position: , mismatch: 5, identity: 0.821

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgaccgggaggcggccggggacctgcgg	Protospacer
***** ************ ****.* .*

71. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_KJ396772 (Streptomyces lavendulae subsp. lavendulae strain CCM3239 plasmid pSA3239, complete sequence) position: , mismatch: 5, identity: 0.821

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgaccgggaggcggccggggacctgcgg	Protospacer
***** ************ ****.* .*

72. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP013345 (Sphingopyxis macrogoltabida strain 203N plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

cgacccggaggcggccggcgacccggag	CRISPR spacer
tgtcgcgcaggcggcgggcgacccggag	Protospacer
.* * ** ******* ************

73. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP024986 (Streptomyces lavendulae subsp. lavendulae strain CCM 3239 plasmid pSA3239, complete sequence) position: , mismatch: 5, identity: 0.821

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgaccgggaggcggccggggacctgcgg	Protospacer
***** ************ ****.* .*

74. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040763 (Paracoccus sp. 2251 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.818

ctcctccgcccggtaggcggcggcccgc-cggtc	CRISPR spacer
gttctccgcccggtaggcggtggcgcgtgcggt-	Protospacer
 *.*****************.*** **. **** 

75. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NC_012520 (Rhodococcus opacus B4 plasmid pROB01, complete sequence) position: , mismatch: 6, identity: 0.818

cgcgccgccgccggggatcgccccga-gtgctgt	CRISPR spacer
ggcgccgccgccgttgatcgccccggcgtgcag-	Protospacer
 ************  **********. **** * 

76. spacer 6.1|960055|32|NZ_CP022961|CRISPRCasFinder matches to NC_013858 (Azospirillum sp. B510 plasmid pAB510d, complete sequence) position: , mismatch: 6, identity: 0.812

cggctgcg-taccggggccggctgcgcggcgga	CRISPR spacer
-agcggcgctaccgcgaccggctgcgcggcggg	Protospacer
 .** *** ***** *.***************.

77. spacer 7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to MN304824 (Catenulispora phage 69_17, complete genome) position: , mismatch: 6, identity: 0.818

agacgtcgtcggcggtcaccgtccggcctcgct	CRISPR spacer
tctcctcgatggcggtcaccgtccggcctcgct	Protospacer
   * *** .***********************

78. spacer 7.17|1075132|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP049908 (Hymenobacter sp. HDW8 plasmid p_unnamed1, complete sequence) position: , mismatch: 6, identity: 0.818

gttcgacgcgcagcgtggagggaatctccgccc	CRISPR spacer
ggtagaagcgcagcgtggcgggaatctccccgc	Protospacer
* * ** *********** ********** * *

79. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_LR134459 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 17, complete sequence) position: , mismatch: 6, identity: 0.812

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
tgacctccgggtcgtcgggggtgccgggcggg	Protospacer
**.. .************ ********.****

80. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to KX397365 (Erwinia phage vB_EamM_Caitlin, complete genome) position: , mismatch: 6, identity: 0.812

---tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
acacggtg---gggacgtcggttgtgccggacggg	Protospacer
   .****   *** ******* ************

81. spacer 15.2|3714985|26|NZ_CP022961|CRISPRCasFinder matches to NZ_CP020568 (Kitasatospora aureofaciens strain DM-1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.769

gtagcgggccggccccggtagcgggc	CRISPR spacer
accccggggcggccccggtagcgggg	Protospacer
..  **** **************** 

82. spacer 15.2|3714985|26|NZ_CP022961|CRISPRCasFinder matches to NZ_CP020952 (Rhizobium sp. CIAT894 plasmid pRheCIAT894e, complete sequence) position: , mismatch: 6, identity: 0.769

gtagcgggccggccccggtagcgggc	CRISPR spacer
tgctctggccggccccggtagcggga	Protospacer
    * ******************* 

83. spacer 17.5|3912565|32|NZ_CP022961|PILER-CR matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.812

accaggctgggcgcccagcctggggcgacggg	CRISPR spacer
gccgtgctgggcgaccagccgggggcgacgga	Protospacer
.**. ******** ****** **********.

84. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 6, identity: 0.786

cgacccggaggcggccggcgacccggag	CRISPR spacer
cggcccggtggcggccggcgaccagcgt	Protospacer
**.***** ************** * . 

85. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 6, identity: 0.786

cgacccggaggcggccggcgacccggag	CRISPR spacer
atatccggaatcggccggcgacccggac	Protospacer
  *.*****. **************** 

86. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 6, identity: 0.8

accggcacggcggtccggggcgggcacggc	CRISPR spacer
accggcacggcgggcccgggcggtggccgc	Protospacer
************* ** ******  .* **

87. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 6, identity: 0.8

accggcacggcggtccggggcgggcacggc	CRISPR spacer
accggcacggcgggcccgggcggtggccgc	Protospacer
************* ** ******  .* **

88. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

--accggcacggcggtccggggcgggcacggc	CRISPR spacer
ggacc--cctggcggtccgcggcgggcacggg	Protospacer
  ***  * .********* *********** 

89. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NC_010627 (Paraburkholderia phymatum STM815 plasmid pBPHY02, complete sequence) position: , mismatch: 6, identity: 0.8

accggcacggcggtccggggcgggcacggc	CRISPR spacer
acacggacgacgctccggggcgggcacgga	Protospacer
**  * ***.** **************** 

90. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP039902 (Agrobacterium tumefaciens strain CFBP5877 plasmid pTiCFBP5877, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
tgtagccggcgcggccgcgtccggcgcggca	Protospacer
 * . ********** * *************

91. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
atggtccggcgcggcacggtccagcgcgtgc	Protospacer
* ************** *****.*****   

92. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP039893 (Agrobacterium tumefaciens strain CFBP5499 plasmid pTiCFBP5499, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
tgtagccggcgcggccgcgtccggcgcggca	Protospacer
 * . ********** * *************

93. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_KY000025 (Agrobacterium genomosp. 6 strain AR125 plasmid pTi_AR125, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
tgtagccggcgcggccgcgtccggcgcggca	Protospacer
 * . ********** * *************

94. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_KY000029 (Agrobacterium genomosp. 6 strain CFBP5499 plasmid pTi_CFBP5499, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
tgtagccggcgcggccgcgtccggcgcggca	Protospacer
 * . ********** * *************

95. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP016905 (Ralstonia solanacearum strain KACC 10709 plasmid unnamed1) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
agtgccgaccgcggccgggtccggcgcggca	Protospacer
** *.* . ****** ***************

96. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
agtgccgaccgcggccgggtccggcgcggca	Protospacer
** *.* . ****** ***************

97. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP009803 (Streptomyces sp. FR-008 plasmid pSSFR1, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccg---gcgcggcagggtccggcgcggca	CRISPR spacer
---gcccgtgcgcgcggcggcgtccggcgcggca	Protospacer
   *.***   *******.* *************

98. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP022194 (Yangia pacifica strain YSBP01 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
atgatccggcgcggctggttccggcgcttca	Protospacer
* *.*********** ** ********  **

99. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to KU963251 (Gordonia phage UmaThurman, complete genome) position: , mismatch: 6, identity: 0.806

agggtccggcgcggcagggtccggcgcggca-	CRISPR spacer
ccggtacggcgcggcacggtccggca-ggcat	Protospacer
  *** ********** ********. **** 

100. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.788

ctcctccgcccggtaggcggcggccc--gccggtc	CRISPR spacer
ccgctccgcccggtcggcggcggcacgtgccga--	Protospacer
*. *********** ********* *  ****.  

101. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040763 (Paracoccus sp. 2251 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.788

ctcctccgcccggtaggcggcggcccgccggtc	CRISPR spacer
cgcatccacccggtcggcggcggcccgcatggc	Protospacer
* * ***.****** *************  * *

102. spacer 5.1|472740|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP021649 (Acidovorax sp. T1 plasmid p1-T1, complete sequence) position: , mismatch: 7, identity: 0.75

cggtcacgcgttgccggcctggtcacgc	CRISPR spacer
tcgtcgcgcgttgccggcctcgtcagtt	Protospacer
. ***.************** ****  .

103. spacer 6.1|960055|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP045288 (Curtobacterium flaccumfaciens pv. flaccumfaciens strain P990 plasmid pCff1, complete sequence) position: , mismatch: 7, identity: 0.781

-cggctgcgtaccggggccggctgcgcggcgga	CRISPR spacer
atcaccgcg-accggggccgcccgcgcggcgga	Protospacer
 . .*.*** ********** *.**********

104. spacer 6.1|960055|32|NZ_CP022961|CRISPRCasFinder matches to CP041260 (Curtobacterium flaccumfaciens pv. flaccumfaciens strain Cff1037 plasmid pCFF113, complete sequence) position: , mismatch: 7, identity: 0.781

-cggctgcgtaccggggccggctgcgcggcgga	CRISPR spacer
atcaccgcg-accggggccgcccgcgcggcgga	Protospacer
 . .*.*** ********** *.**********

105. spacer 7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NC_019018 (Mycobacterium marinum DL240490 plasmid pMUM003, complete sequence) position: , mismatch: 7, identity: 0.788

ccgctgtgaccaaggacggcaagacggtcttgg	CRISPR spacer
ccgctgtgaccaaggacatcaagaccctcgatg	Protospacer
*****************. ******  **   *

106. spacer 7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NC_011355 (Mycobacterium liflandii 128FXT plasmid pMUM002, complete sequence) position: , mismatch: 7, identity: 0.788

ccgctgtgaccaaggacggcaagacggtcttgg	CRISPR spacer
ccgctgtgaccaaggacatcaagaccctcgatg	Protospacer
*****************. ******  **   *

107. spacer 7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP017625 (Mycobacterium ulcerans subsp. shinshuense strain ATCC 33728 plasmid pShTP, complete sequence) position: , mismatch: 7, identity: 0.788

ccgctgtgaccaaggacggcaagacggtcttgg	CRISPR spacer
ccgctgtgaccaaggacatcaagaccctcgatg	Protospacer
*****************. ******  **   *

108. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.781

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
gcatgcgcgggtcgtcggtggtgccgatgggg	Protospacer
  .*** *******************.  ***

109. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 7, identity: 0.781

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
gcatgcgcgggtcgtcggtggtgccgatgggg	Protospacer
  .*** *******************.  ***

110. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 7, identity: 0.781

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
gcatgcgcgggtcgtcggtggtgccgatgggg	Protospacer
  .*** *******************.  ***

111. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP019037 (Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.781

-tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
gcggcg-tcgggtcgcccgtggtgccggacgtg	Protospacer
 .**.* .*******.* ************* *

112. spacer 19.3|3923015|35|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 7, identity: 0.8

---cccaacccaacatggccggcatgctcgccacgctg	CRISPR spacer
gcacccga---atcatggccgggctgctcgccacgctg	Protospacer
   ***.*   * *********  **************

113. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NC_047816 (Ralstonia phage RS-PI-1, complete genome) position: , mismatch: 7, identity: 0.794

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
gccatcgcctcggcgacgacaccgccgctcgcca	Protospacer
 ***************** ********   *. *

114. spacer 21.1|3959380|28|NZ_CP022961|CRISPRCasFinder matches to NZ_CP045548 (Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.75

cgacccggaggcggccggcgacccggag	CRISPR spacer
cgacgcggaggcggccgacgacctcacc	Protospacer
**** ************.*****. .  

115. spacer 22.1|4497892|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP004394 (Celeribacter indicus strain P73 plasmid pP73A, complete sequence) position: , mismatch: 7, identity: 0.794

ccgtcgtcctgacggacatgggccagt---cgctgaa	CRISPR spacer
ccgtcgtgcttacggacatgggccggcgcgcgct---	Protospacer
******* ** *************.*.   ****   

116. spacer 25.1|4922051|33|NZ_CP022961|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 7, identity: 0.788

cgccgcgctcgtgccggtccgggtggacgtggc---	CRISPR spacer
cgccgcgctcgagccggaccgggtg---gcgaccca	Protospacer
*********** ***** *******   *.*.*   

117. spacer 25.1|4922051|33|NZ_CP022961|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 7, identity: 0.788

cgccgcgctcgtgccggtccgggtggacgtggc---	CRISPR spacer
cgccgcgctcgagccggaccgggtg---gcgaccca	Protospacer
*********** ***** *******   *.*.*   

118. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 7, identity: 0.767

accggcacggcggtccggggcgggcacggc	CRISPR spacer
gaaggcacggcggtccggggcgcgcgcaac	Protospacer
.  ******************* **.*..*

119. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NC_015583 (Novosphingobium sp. PP1Y plasmid Mpl, complete sequence) position: , mismatch: 7, identity: 0.767

accggcacggcggtccggggcgggcacggc	CRISPR spacer
cccggcacggcgatccggggcggaaatacc	Protospacer
 ***********.**********. *.. *

120. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to NZ_CP036516 (Lichenihabitans psoromatis strain PAMC 29148 plasmid p_unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

accggcacggcggtccggggcgggcacggc-	CRISPR spacer
cacggcacggcggtccgcggcggat-cgacg	Protospacer
  *************** *****.. **.* 

121. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP022991 (Paraburkholderia aromaticivorans strain BN5 plasmid pBN1, complete sequence) position: , mismatch: 7, identity: 0.774

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
tattttcggcgcggccgggtccggcgcgtca	Protospacer
 .  *.********* ************ **

122. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP035424 (Leisingera sp. NJS204 plasmid unnamed7, complete sequence) position: , mismatch: 7, identity: 0.774

agggtccg----gcgcggcagggtccggcgcggca	CRISPR spacer
----tccagcttgcgccgcagggtccggcgcgaca	Protospacer
    ***.    **** ***************.**

123. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NC_018696 (Paraburkholderia phenoliruptrix BR3459a plasmid pSYMBR3459, complete sequence) position: , mismatch: 7, identity: 0.774

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
atggtccggcgcggccgtgtccggcatgcct	Protospacer
* ************* * *******..* * 

124. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.811

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
cgtacccgtgccggtgccggtgccggtggcgctcgcc	Protospacer
. *  * ******************** ** ******

125. spacer 3.4|399596|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to JX006077 (Saccharomonospora phage PIS 136, complete genome) position: , mismatch: 8, identity: 0.758

ctgccggagaaacatctccggccgcaaccgtaa	CRISPR spacer
gtgccggaacaacatctccggccgcaacaccct	Protospacer
 *******. ******************  .  

126. spacer 3.5|399657|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020716 (Cnuibacter physcomitrellae strain XA(T) plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.758

cccggaggcgacccgcgcggatatgtaacagcc-	CRISPR spacer
accggaggcgcccagcgcggatatg-gtcggctc	Protospacer
 ********* ** *********** . *.**. 

127. spacer 3.5|399657|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NC_017791 (Deinococcus gobiensis I-0 plasmid P2, complete sequence) position: , mismatch: 8, identity: 0.758

cccggaggcgacccgcgcggatat-----gtaacagcc	CRISPR spacer
cccggaggcgacccgtgcggagatcgcgcgcaa-----	Protospacer
***************.***** **     *.**     

128. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NC_017957 (Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence) position: , mismatch: 8, identity: 0.758

ctcctccgcccggtaggcggcggcccgccggtc	CRISPR spacer
cgccatgtgccggaaggcggcggcgcgccggtc	Protospacer
* ** .   **** ********** ********

129. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054621 (Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence) position: , mismatch: 8, identity: 0.758

ctcctccgcccggtaggcggcggcccgccggtc	CRISPR spacer
aatctccgcccggaaggcggcggcccgctccgc	Protospacer
  .********** **************.   *

130. spacer 3.12|400084|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010408 (Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence) position: , mismatch: 8, identity: 0.758

gcgggccatcaccccggtcgccggcttgcggcg	CRISPR spacer
gtccgccaccaccccggtcgccgacttggtccg	Protospacer
*.  ****.**************.****   **

131. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to MN582066 (Siphoviridae sp. ctpQM7, complete genome) position: , mismatch: 8, identity: 0.758

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
cgcgccgccgccgcggatcgctccgacggaaaa	Protospacer
************* *******.****  *  . 

132. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to LR743523 (Xylella phage Usme genome assembly, chromosome: 1) position: , mismatch: 8, identity: 0.758

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
cacgccgccgccggggatcacgccgaagaacgt	Protospacer
*.*****************.* ****. . .**

133. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to LR743529 (Xanthomonas phage Sopo genome assembly, chromosome: 1) position: , mismatch: 8, identity: 0.758

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
cacgccgccgccggggatcacgccgaagaacgt	Protospacer
*.*****************.* ****. . .**

134. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to LR743528 (Xanthomonas phage Tabio genome assembly, chromosome: 1) position: , mismatch: 8, identity: 0.758

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
cacgccgccgccggggatcacgccgaagaacgt	Protospacer
*.*****************.* ****. . .**

135. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to LR743531 (Xanthomonas phage Tenjo genome assembly, chromosome: 1) position: , mismatch: 8, identity: 0.758

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
cacgccgccgccggggatcacgccgaagaacgt	Protospacer
*.*****************.* ****. . .**

136. spacer 3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 8, identity: 0.758

gggcggcaggcccttcagccacaggcaggtcgt	CRISPR spacer
cggcggcaggcccgccagccacaggacgctggc	Protospacer
 ************ .**********  * * *.

137. spacer 3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.758

gggcggcaggcccttcagccacaggcaggtcgt	CRISPR spacer
cggcggcaggcccgccagccacaggacgctggc	Protospacer
 ************ .**********  * * *.

138. spacer 3.24|400816|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.758

gggcggcaggcccttcagccacaggcaggtcgt	CRISPR spacer
cggcggcaggcccgccagccacaggacgctggc	Protospacer
 ************ .**********  * * *.

139. spacer 6.1|960055|32|NZ_CP022961|CRISPRCasFinder matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 8, identity: 0.75

cggctgcgtaccggggccggctgcgcggcgga	CRISPR spacer
tgaggccgtactggggccggctgcacggcggc	Protospacer
.*.   *****.************.****** 

140. spacer 7.10|1074705|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.758

gcggtg-gccggccgccaccacacacgcgccgag	CRISPR spacer
-cgtcgaaccggcctccaccacacccgcgccggc	Protospacer
 ** .* .****** ********* *******. 

141. spacer 7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.758

agacgtcgtcggcggtcaccgtccggcctcgct	CRISPR spacer
ggatctgcccggcgctcaccgtccggccccgct	Protospacer
.**. *  .***** *************.****

142. spacer 7.19|1075254|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040722 (Rhodococcus pyridinivorans strain YF3 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.758

gcatggcgctcggtccggtgagtcagcgcctgc	CRISPR spacer
ccgcggcggtcggtcgggtgagtcagcgcggcc	Protospacer
 *..**** ****** *************   *

143. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.765

atgccgtcccgccggcggcccggccgctcgggag---	CRISPR spacer
atgccgtcgcgccggtggcccg---gctcgaggtcgc	Protospacer
******** ******.******   *****.*.    

144. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 8, identity: 0.765

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
atcatcgcctcggcgacgtcctcgccgaaggggc	Protospacer
 .****************** .******..* * 

145. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP023549 (Rhodobacter sp. CZR27 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
catgagcggcgcggcagcttccggcgcggcg	Protospacer
 . *  ***********  ***********.

146. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP033321 (Azospirillum brasilense strain Cd plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
cgctcgcggcgcggcagggtccggaacggcg	Protospacer
 *  . ****************** .****.

147. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP033315 (Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
cgctcgcggcgcggcagggtccggaacggcg	Protospacer
 *  . ****************** .****.

148. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP019083 (Paludisphaera borealis strain PX4 plasmid PALBO1, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
ctggtccggcgcggcgggggccggcggcgtc	Protospacer
  *************.*** ******  *. 

149. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NC_017805 (Deinococcus gobiensis I-0 plasmid P1, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
gcggcgcggcgcggcggggtccggcgcgtgg	Protospacer
. **. *********.************  .

150. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032342 (Azospirillum brasilense strain MTCC4038 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
cgctcgcggcgcggcagggtccggaacggcg	Protospacer
 *  . ****************** .****.

151. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP015867 (Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
tccggccggcgcggcggggtccggctcgcct	Protospacer
   * **********.********* ** * 

152. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 8, identity: 0.742

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
cagtgccggcgccgcaggatccggcgcgcga	Protospacer
 .*  ******* *****.*********  *

153. spacer 3.2|399474|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NC_021321 (Halovirus HRTV-8, complete genome) position: , mismatch: 9, identity: 0.727

ctgcaacctcggtcacgtcaatctcggcgcctt	CRISPR spacer
gtgcaacctcggtcacatcaacctcagtctgat	Protospacer
 ***************.****.***.*. .  *

154. spacer 3.7|399779|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to KM378617 (Vibrio phage VpKK5, complete genome) position: , mismatch: 9, identity: 0.727

gtcgaccaagaccgtcttgccatccttggtcac	CRISPR spacer
gtcgacaaagaccttcttgccatcggctctgat	Protospacer
****** ****** **********  .  * *.

155. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049908 (Hymenobacter sp. HDW8 plasmid p_unnamed1, complete sequence) position: , mismatch: 9, identity: 0.727

ctcctccgcccggtaggcggcggcccgccggtc	CRISPR spacer
cccgagtgcccggtacgcggtggcccgccggca	Protospacer
*.*   .******** ****.**********. 

156. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037921 (Hymenobacter sp. 17J36-26 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.727

ctcctccgcccggtaggcggcggcccgccggtc	CRISPR spacer
cccgagtgcccggtacgcggtggcccgccggca	Protospacer
*.*   .******** ****.**********. 

157. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to MH576962 (Streptomyces phage Satis, complete genome) position: , mismatch: 9, identity: 0.727

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
ggcgccgccgccggggctcgccccgaacttgcc	Protospacer
 *************** *********.. .  .

158. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to MK620894 (Streptomyces phage Kradal, complete genome) position: , mismatch: 9, identity: 0.727

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
ggcgccgccgccggggctcgccccgaacttgcc	Protospacer
 *************** *********.. .  .

159. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034153 (Rhodococcus sp. NJ-530 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.727

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
gccgccgcccccggggatcaccccgagtttgac	Protospacer
  ******* *********.******** . ..

160. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134451 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence) position: , mismatch: 9, identity: 0.727

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
gccgccgccgccggggatcacgccgagcaggat	Protospacer
  *****************.* *****..  .*

161. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.727

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
ctggccgccgccggcgagcgccccgaggcgcgc	Protospacer
*  *********** ** *********   .*.

162. spacer 3.25|400877|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018468 (Xanthomonas vesicatoria strain LM159 plasmid pLM159.1, complete sequence) position: , mismatch: 9, identity: 0.727

gccgtagagcgcgctcgatcggttgcgcgggtt	CRISPR spacer
ctggtagagcgcgcacgatcgcttgcggcaatt	Protospacer
 . *********** ****** *****  ..**

163. spacer 6.1|960055|32|NZ_CP022961|CRISPRCasFinder matches to NC_048790 (Corynebacterium phage Lederberg, complete genome) position: , mismatch: 9, identity: 0.719

cggctgcgtaccggggccggctgcgcggcgga	CRISPR spacer
ggccccggttccggggccggctgggcggcgtc	Protospacer
 * *.  ** ************* ******  

164. spacer 7.3|1074278|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to KY798216 (Mycobacterium phage Journey13, complete genome) position: , mismatch: 9, identity: 0.727

aggacggtgacgatggacaacccgatcgccgtg	CRISPR spacer
ccagcggtgacgatggacaacgcgctcgacctt	Protospacer
  ..***************** ** *** * * 

165. spacer 7.8|1074583|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP044989 (Deinococcus sp. AJ005 plasmid p380k, complete sequence) position: , mismatch: 9, identity: 0.727

ccgctgtgaccaaggacggcaagacggtcttgg	CRISPR spacer
acagcctgtccaaggacggcaagaccgtctcgc	Protospacer
 *. . ** **************** ****.* 

166. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP047175 (Rathayibacter sp. VKM Ac-2760 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
cggtgaccgggtggtcggtggtgccctcgtga	Protospacer
.**** ****** ************     *.

167. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_LR134460 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 18, complete sequence) position: , mismatch: 9, identity: 0.719

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
cgcggcccgggccgtcggtcgtgccggcgctg	Protospacer
.*  *******.******* *******    *

168. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to MT310875 (Microbacterium phage Ashton, complete genome) position: , mismatch: 9, identity: 0.719

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
cgctgccggtgtcgtcggtggtgccgttgctg	Protospacer
.* **** * ****************     *

169. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NC_048761 (Microbacterium phage Akoni, complete genome) position: , mismatch: 9, identity: 0.719

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
cgctgccggtgtcgtcggtggtgccgttgctg	Protospacer
.* **** * ****************     *

170. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033583 (Streptomyces sp. ADI95-16 plasmid pADI95-16b, complete sequence) position: , mismatch: 9, identity: 0.735

atgccgtcccgccggcggcccggccgctcgggag	CRISPR spacer
aggacgacgcgccggcggcccggccgctccccgc	Protospacer
* * ** * ********************   . 

171. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011667 (Streptomyces sp. Mg1 plasmid pSMg1-3, complete sequence) position: , mismatch: 9, identity: 0.735

atgccgtcccgccggcggcccggccgctcgggag	CRISPR spacer
aggacgacgcgccggcggcccggccgctccccgc	Protospacer
* * ** * ********************   . 

172. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015368 (Methylobacterium phyllosphaerae strain CBMB27 plasmid CBMB27-p1, complete sequence) position: , mismatch: 9, identity: 0.735

atgccgtcccgccggcggcccggccgctcgggag	CRISPR spacer
gttcgcgcgcggcggcggcccggccgcccgggat	Protospacer
.* *   * ** ***************.***** 

173. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
tcccgggcctcggcgacgtagccgccgagatcgc	Protospacer
.**   ************* .********* .* 

174. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
tcccgggcctcggcgacgtagccgccgagatcgc	Protospacer
.**   ************* .********* .* 

175. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
tcggacgcctcggcgacgtcaccttcgagggcgc	Protospacer
.* . ****************** .****.*.* 

176. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
tcggacgcctcggcgacgtcaccttcgagggcgc	Protospacer
.* . ****************** .****.*.* 

177. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
tcggacgcctcggcgacgtcaccttcgagggcgc	Protospacer
.* . ****************** .****.*.* 

178. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP024940 (Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga--	CRISPR spacer
cccatcgcttcggcgacgacaccg--aagcccggtc	Protospacer
********.********* *****  .**  .*.  

179. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to MH779501 (Gordonia phage Emianna, complete genome) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
cggttggcctcggcgacgtcactggcgagatcgt	Protospacer
*   * ****************.* ***** .* 

180. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to MH727547 (Gordonia phage Foxboro, complete genome) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
cggttggcctcggcgacgtcactggcgagatcgt	Protospacer
*   * ****************.* ***** .* 

181. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to MH779510 (Gordonia phage Kurt, complete genome) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
cggttggcctcggcgacgtcactggcgagatcgt	Protospacer
*   * ****************.* ***** .* 

182. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to MH779508 (Gordonia phage Jifall16, complete genome) position: , mismatch: 9, identity: 0.735

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
cggttggcctcggcgacgtcactggcgagatcgt	Protospacer
*   * ****************.* ***** .* 

183. spacer 27.1|5008568|30|NZ_CP022961|CRISPRCasFinder matches to LR606148 (Rhizobium sp. Q54 genome assembly, plasmid: 5) position: , mismatch: 9, identity: 0.7

accggcacggcggtccggggcgggcacggc	CRISPR spacer
tgaagaggtgcggtccggggcgggcacagc	Protospacer
   .* .  ******************.**

184. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
gtccgccggcgcgtcagggtcccgcgcgtcc	Protospacer
.    ******** ******** ***** * 

185. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
cctggtgggcgcggcagattccggcgcggcg	Protospacer
   * . **********. ***********.

186. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP013632 (Rhizobium sp. N324 plasmid pRspN324b, complete sequence) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
ttcgatcggcgcggcgggggccggcgcggtt	Protospacer
   * .*********.*** *********. 

187. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to MT740729 (Ralstonia phage Bakoly, complete genome) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
aggggccggcgcggcggggtccgcttctttc	Protospacer
**** **********.******* . *  . 

188. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP029358 (Azospirillum sp. CFH 70021 plasmid unnamed3) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
cctggtgggcgcggcagattccggcgcggcg	Protospacer
   * . **********. ***********.

189. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP014797 (Salipiger profundus strain JLT2016 plasmid pTPRO1, complete sequence) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
gcgcgccggcgcggtcgggtccggcgcgaag	Protospacer
. *  *********. ************. .

190. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to MT740747 (Ralstonia phage Simangalove, complete genome) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
aggggccggcgcggcggggtccgcttctttc	Protospacer
**** **********.******* . *  . 

191. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to MT740744 (Ralstonia phage Jenny, complete genome) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
aggggccggcgcggcggggtccgcttctttc	Protospacer
**** **********.******* . *  . 

192. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to MT740735 (Ralstonia phage Elie, complete genome) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
aggggccggcgcggcggggtccgcttctttc	Protospacer
**** **********.******* . *  . 

193. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to MT740746 (Ralstonia phage Sarlave, complete genome) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
aggggccggcgcggcggggtccgcttctttc	Protospacer
**** **********.******* . *  . 

194. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to MT740725 (Ralstonia phage Adzire, complete genome) position: , mismatch: 9, identity: 0.71

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
aggggccggcgcggcggggtccgcttctttc	Protospacer
**** **********.******* . *  . 

195. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to JN699011 (Mycobacterium phage Stinger, complete genome) position: , mismatch: 9, identity: 0.757

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
catcgcggtgccgatgccggtggcggtcggccacacg	Protospacer
. ***********.******** ****** .* *.* 

196. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to NC_011044 (Mycobacterium phage Nigel, complete genome) position: , mismatch: 9, identity: 0.757

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
catcgcggtgccgatgccggtggcggtcggccacacg	Protospacer
. ***********.******** ****** .* *.* 

197. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 9, identity: 0.757

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
tcttccggtgccggtgccggtgccggagaccacggcc	Protospacer
***. *********************  .*. . ***

198. spacer 3.10|399962|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027299 (Streptomyces sp. SGAir0924 plasmid unnamed_5) position: , mismatch: 10, identity: 0.697

ctcctccgcccggtaggcggcggcccgccggtc	CRISPR spacer
gaacaccgcccggtaggcggcctcccgccacag	Protospacer
   * ****************  ******.   

199. spacer 3.16|400328|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027299 (Streptomyces sp. SGAir0924 plasmid unnamed_5) position: , mismatch: 10, identity: 0.697

tgtcctggtagctcttgccggacgcggcgggtt	CRISPR spacer
ggagctgatagctcttgccgtacgcggcttccc	Protospacer
 *  ***.************ *******   ..

200. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044329 (Methylocystis rosea strain BRCS1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.697

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
ggcgccgccgccggcgagcgccccggcgatttc	Protospacer
 ************* ** *******.  ..* .

201. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015231 (Epibacterium mobile F1926 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.697

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
cgggccgacgccggggatcgccccaatcagcac	Protospacer
** **** ****************.* .. ...

202. spacer 3.20|400572|33|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041975 (Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP 16207 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.697

cgcgccgccgccggggatcgccccgagtgctgt	CRISPR spacer
tggttcgccgtcggggattgccccgagtggcag	Protospacer
.*  .*****.*******.********** .. 

203. spacer 7.3|1074278|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LN890657 (Candidatus Promineofilum breve strain Cfx-K plasmid III, complete sequence) position: , mismatch: 10, identity: 0.697

aggacggtgacgatggacaacccgatcgccgtg	CRISPR spacer
gccgagttgacgatggacatcctgatcgccggc	Protospacer
.  . * ************ **.********  

204. spacer 7.14|1074949|33|NZ_CP022961|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 10, identity: 0.697

agacgtcgtcggcggtcaccgtccggcctcgct	CRISPR spacer
ggacgtcgtcggtggtcaccgtgcggatggtgg	Protospacer
.***********.********* *** .     

205. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NC_015728 (Roseobacter litoralis Och 149 plasmid pRLO149_83, complete sequence) position: , mismatch: 10, identity: 0.688

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
tcagatccaggtcgtcgatggtgccggacacc	Protospacer
* . ..**.********.***********.  

206. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NZ_CP048426 (Rhizobium daejeonense strain KACC 13094 plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.688

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
gattgcccgggtcctcggtggcgccgcggccg	Protospacer
 . ********** *******.**** .   *

207. spacer 8.1|1402159|32|NZ_CP022961|CRISPRCasFinder matches to NC_019959 (Mycobacterium sp. JS623 plasmid pMYCSM03, complete sequence) position: , mismatch: 10, identity: 0.688

tggtgcccgggtcgtcggtggtgccggacggg	CRISPR spacer
gctcgcccgcgtcgtcggtggcgccgggcaac	Protospacer
   .***** ***********.*****.*.. 

208. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022541 (Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence) position: , mismatch: 10, identity: 0.706

atgccgtcccgccggcggcccggccgctcgggag	CRISPR spacer
atgccgtcgcgccggcggccctgccattacctga	Protospacer
******** ************ ***..*    ..

209. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP003988 (Streptomyces sp. 769 plasmid pSGZL, complete sequence) position: , mismatch: 10, identity: 0.706

atgccgtcccgccggcggcccggccgctcgggag	CRISPR spacer
ggcccgtcccgccagcggcccgggcgcttgtcca	Protospacer
.  **********.********* ****.*   .

210. spacer 17.3|3912436|34|NZ_CP022961|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134460 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 18, complete sequence) position: , mismatch: 10, identity: 0.706

atgccgtcccgccggcggcccggccgctcgggag	CRISPR spacer
ggtcgcccccgccggcgccccggccgctccggct	Protospacer
.  *  .********** *********** **  

211. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP044544 (Bradyrhizobium betae strain PL7HG1 plasmid pBbPL7HG1, complete sequence) position: , mismatch: 10, identity: 0.706

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
ttctgcgcgtcggcgacgtaaccgccgagatcac	Protospacer
..*  *** ********** ********** .. 

212. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NZ_CP013586 (Rhizobium phaseoli strain N161 plasmid pRphaN161a, complete sequence) position: , mismatch: 10, identity: 0.677

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
gactgatggagcggcaggggccggcgcggcc	Protospacer
..    .** ********* ********** 

213. spacer 28.2|5238997|31|NZ_CP022961|CRISPRCasFinder matches to NC_031059 (Rhodovulum phage vB_RhkS_P1, complete genome) position: , mismatch: 10, identity: 0.677

agggtccggcgcggcagggtccggcgcggca	CRISPR spacer
ttccaccggcgcggccggggccggcgcgctg	Protospacer
     ********** *** ******** ..

214. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to NC_006571 (Streptomyces albulus plasmid pNO33 DNA, complete sequence) position: , mismatch: 10, identity: 0.73

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
ggtggcggtgccggtcgcggtgccggtcgcggcccct	Protospacer
  * ***********  *************  .* *.

215. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP047181 (Rathayibacter festucae strain VKM Ac-2802 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.676

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
gcaccagccgcggcgacggcaccgccgagatcct	Protospacer
 *  . *** ******** *********** .  

216. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP047184 (Rathayibacter sp. VKM Ac-2801 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.676

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
gcaccagccgcggcgacggcaccgccgagatcct	Protospacer
 *  . *** ******** *********** .  

217. spacer 19.5|3923148|34|NZ_CP022961|PILER-CR,CRISPRCasFinder matches to NZ_CP047177 (Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.676

cccatcgcctcggcgacgtcaccgccgagagtga	CRISPR spacer
gcaccagccgcggcgacggcaccgccgagatcct	Protospacer
 *  . *** ******** *********** .  

218. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to MN234171 (Mycobacterium phage Magpie, complete genome) position: , mismatch: 11, identity: 0.703

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
catcgcggtgccgatgccggtggcggtcagccatacg	Protospacer
. ***********.******** *****. .* ..* 

219. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to NC_042034 (Mycobacterium phage ChrisnMich, complete sequence) position: , mismatch: 11, identity: 0.703

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
catcgcggtgccgatgccggtggcggtcagccatacg	Protospacer
. ***********.******** *****. .* ..* 

220. spacer 29.1|5330675|37|NZ_CP022961|CRISPRCasFinder matches to KF493881 (Mycobacterium phage JAMaL, complete genome) position: , mismatch: 11, identity: 0.703

tctcgcggtgccggtgccggtgccggtcgctctcgcc	CRISPR spacer
catcgcggtgccgatgccggtggcggtcagccatacg	Protospacer
. ***********.******** *****. .* ..* 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2689769 : 2698477	8	uncultured_Mediterranean_phage(33.33%)	NA	NA
DBSCAN-SWA_2	4314164 : 4380006	37	uncultured_Mediterranean_phage(33.33%)	integrase,transposase	attL 4361617:4361633|attR 4368096:4368112
DBSCAN-SWA_3	5424797 : 5494945	47	Tupanvirus(33.33%)	integrase,tRNA,transposase	attL 5433497:5433556|attR 5494898:5496346
DBSCAN-SWA_4	5919606 : 5970478	48	Anomala_cuprea_entomopoxvirus(25.0%)	tRNA,transposase	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP022961|2689769:2698477|DBSCAN-SWA
GTTGGCTTCAGCACGGACGATCCGGCACATCTTCGTCACCGGGGGCGTCGCCTCCTCCCTGGGCAAGGGCCTGACCGCCTCGAGCCTGGGCAACCTGCTGTCGGCGCGCGGGCTGCGGGTCGTCATGCAGAAGCTCGACCCCTACCTCAACGTCGATCCGGGCACGATGAACCCGTTCCAGCACGGCGAGGTGTTCGTCACCGACGACGGCGCCGAGACCGACCTCGACGTGGGACATTACGAGCGATTCCTGGATCGGGACCTTTCCGGCAAGGCGAACGTCACCACCGGGCAGATCTACTCGGACGTCATCGCCAAGGAGCGCCGCGGCGAGTACCTGGGCGACACCGTCCAGGTCATCCCGCACATCACCAACGAGATCAAGTCCCGGATCCTGGCCCTGGGCGATCCGGACGAGGACGGCCGGACACCGGACGTGGTGATCACCGAGGTCGGCGGCACCGTCGGCGACATCGAGTCGCTGCCGTTCCTGGAGGCGATCCGCCAGATCCGGCACGACCTCGGCCGGGACAACTGCTTCTACCTGCACGTCTCGCTGGTGCCCTACCTCGCCCCCTCGGGCGAGCTGAAGACCAAGCCCACCCAGCACTCGGTGGCGCAGCTGCGGAACATCGGCATCCAGCCCGACGCCATCGTCTGCCGGTCGGACCGGGAGATCCCGGACAAGCTCAAGCACAAGCTGTCGCTGTACTGCGACGTGGACGCCGAGGCCGTGATCGCCTGCCCGGACGCGCCGAGCATCTACGACATCCCCAAGGTGCTGCACGCCGAGGGCCTGGACGCGTACGCGGTGCGCCGGCTCGGCCTGTCCTTCCGGGACGTCGACTGGACCAGCTGGGACGACCTGCTGGAGCGGGTGCACCGGCCCCGGCACACCGTGCGGGTCGCGCTGGTCGGCAAGTACGTCGACCTGCCCGACGCGTACCTGTCGGTGAGCGAGGCGATCCGGGCCGCCGGCTTCGGCCACCGGGCCCGGGTGGAGCTGCGCTGGGTGCCGAGCGACGACTGCGTCAGCCCGACCCGGGCGGCGGCCGCGCTGGCCGGGGTGGACGGCATCGTGATCCCCGGCGGGTTCGGGGTCCGCGGGATCGAGGGCAAGATCGGCGCCGCCCGGTACGCGCGGGAGAACGGCATCCCGATCCTCGGCCTCTGCCTCGGGTTGCAGTGCATGACCATCGAGGTGGCGCGGCACCTGGCCGGCCTGGACGGCGCCGACTCGCTGGAGTTCGACGAGCAGGCCGTGCACCCGGTGATCGCCACCATGGCCGACCAGGAGGACATCGTGGCCGGCCGCGGCGACCTGGGCGGCACGATGCGGCTGGGGGCGTACCCGGCGGTGCTGACCGAGGGGACGATCGTGGCCGACGCGTACGGGCGGACCGAGGTCAGCGAGCGGCACCGGCACCGCTACGAGGTCAACAACGCCTACCGGGACGTGCTGACGAAGGCGGGCCTGCGGGTCAGCGGTACGTCGCCGGACGGCCGGCTGGTCGAGTTCGTCGAGCTGGAGCGCGACCTGCACCCGTTCTTCGTGGCCACCCAGGCGCATCCGGAGCTGAAGAGCCGCCCCACCCGGCCGCATCCGCTGTTCGCGGCCTTCGTCCGCGCCGTCGTGGCGTACTCCGAGGCCGACCAGCTTCCGGTGGAGCTGGACCCGGCCGGTTCGCCGTCGTGACCGCGCACCGGTACGAGGTCCGGTCCCGGCGGGACCGGTTCCGGGGCCGGGTCTTCTCGGTGGTCACCGACGAGGTGACGATGCCCGGCGGCGGCGTCGCCGACCGGGACTACGTCCGGCACGTCGGGTCGGTCGGCGTGGTGGCGCTGGACGAGCGGGGGCAGGTGGTGCTGATCCGGCAGTACCGGCACCCGGTCGGCCGGATCATGTGGGAGCTGCCCGCCGGCCTGGTCGACGTGGCCGGTGAGGACCTGGCCGCCGCGGCCGGCCGGGAACTGGCCGAGGAGGCGGACCTGCTGGCCGGCCGGCTGGACACGCTTGTCGACCTGCACACCTCGCCGGGCTTCAGCGACGAGGCCATCCGGATCTTCCTGGCCCGCGAGCTGTCCGAGGTGCCGCCGGACCGCCGGCACGACCGCCGGGACGAGGAGGCGGAACTGTCGGTGGTCCGGCTGCCGCTGGAGCGCGCGGTGGCCATGGTGCTGAGCGGTGAGATCACCAACGCGGCCTGCGTGGCCGGAGTGCTGGCCGCGGCGCGGGCCCGGGACGCCGACTGGGCGCCGCTGCGCCCGAGCGATGCGCCGCGCTGATTGGCGGACGTGCCGCGACCGATCGGCGGCGGACGTGGTGCCGGTCCGGGCCCCGTTTCGTCGCGATCGTCACCGGCGGTGACCTCGCCGACCGCGACAAGCCCTTGAACGGCCATGCCGGAGAGTCATGGGGATGACTCTCCGGCATGGTCGCGAAAGGGTGCGGTCGATCCCGGCCCGGTGTCCGCGGATCGCCGTCGGCGCCCGGTCCGTCCGGTTCCGGCCCGGCTAGTCGGCCAGCGGTCGTCCCTGGCCGTCGACGCCGCCGTTGACGAGGATCAGGATCCCGTCGATGAATCCCCAGAGGTAGCCGAGTCCGCAGGTGCAAAAGCTCACCACGAGCTGAAGGACACCGGTCTTGGTGTCGCCCATGTAGAACCGGCCAGCACCGAAGCCGCCGAGCAGGATGCCGAGGATGCCGGCGACGACCTTGCTCTTGTCCGAGACACCCATCGGGTGCTGGTAGCCCGCCTGCTGCGGATAGCCCGCCTGCTGCGGGTAGCCGGGCTGTTGCGGATAGCCGGGCTGTTGTTGGTACGGATCTGTCATGAGGGCAGAGAGTAGATGATCTAACGCACGGTGACGTCCCCCAGGGGGCGCCGACAATGAACCCTTCCGTCGCACAATTCCGCCGGGAAGGCGCCGCGCCGGGCACCTGACACATCGTCAGGGCAGGCGATCACTCCCTGTCACAATGCAGGCTGCCGCGCCCGGCGCCCGGTCCTAGACTGACCGCCTGCGGGTGTGGCGGATGGTGGCGGCAACGGAGCCGTCGCGCGCCGAGCGGCCGGAGCGGGTGTCCGGCAGGAGGGTGTCAGCATCGTGAAGGTCGGAGTCCCGCGCGAGGTCAAGAACCACGAGTACCGCGTGGCGATCACCCCTGCGGGCGTCAACGAGTTCGTCCGCGCCGGACACCAGGTCTGCCTCGAAACCGGCGCCGGTGCCGGATCCTCCATCACCGACGCCGAGTTCGCGGCCGCCGGTGCGACCATCCTGGACACCGCCGACGAGGTGTGGGCGACCGCCGACCTGGTGCTGAAGGTCAAGGAGCCGGTGGCGCAGGAGTACCACCGGATGCGTCCCGGGCAGGTGCTCTTCACCTACCTGCACCTGGCCGCCTCCAAGGAGTGCACCGACGCGCTGCTGGACCGCGGCGTCACCGGCATCGCGTACGAGACCGTGGAACTGCCGGACCGCTCGCTGCCGCTGCTGGCCCCGATGTCCGAGGTCGCCGGCCGGCTCGCGCCGCAGGTCGGCGCGTACCACCTGCAACGGCCCGGCGGCGGCCGGGGCGTGCTGATGGGCGGCGTCTCCGGGGTGTACGCCGCCAAGACCGTGGTCATCGGCGCCGGGGTGTCCGGGATGAACGCCGCGGCCATCGCGCTCGGCCTCCAGGCCGAGGTGCTGCTGCTGGACAAGAACGTGGCCCGGCTGCGCCAGGCCGACGCGATCTACCGCGGCCACCTGCAGACCGTCGCGTCCAACGCGTACGAGATCGAGCGGGCCGTGCTGGACGCGGACCTGGTGATCGGCGCGGTGCTGGTGCCCGGAGCCAAGGCCCCGACGCTGATCTCCAACGAACTGGTGTCCCGGATGAAGCCGGGCAGCGTGCTGGTGGACATCTCCATCGACCAGGGCGGCTGCTTCGAGGACTCCCGGCCGACCACGCACGCCGAGCCTGTGTACCCGGTGCACCGGTCGCTGTTCTACTGCGTGGCGAACATGCCCGGCGCGGTCCCGCACACCAGCACCTACGCGCTGACCAACGTCACCCTGCCGTACGCGCTGGAACTGGCCAACCACGGCTGGCGGGAGGCGCTGCGCCGGGACCCGGCGCTGGCCCTCGGCCTGAACACGCACGACGGCCAGGTCACCTACGGCCCGGTCGCCGAGGCGCACGGCATGACCTCCGCCGCCCTGGCCGACGTGCTCGGCTGAGGCGTGCCGACCGGAGTGCCGGACGGACCGGATCCGGCGGCCGGAACGGCACCGGAGCCGTCGCCCGCGCTGCGCCGGGCCGTGCGCGGCTACCTCGACCACCTCACGGTCGAGCGCGGCCTGTCGGCCAACACGCTCTCGTCGTACCGCCGGGACCTGGCGCGCTACCTCGCCGGCCTCGCGGCCGACGGCATCGGCGACCTCGCCGCGGTCGGCCCCGCGGACGTCGCCGCGCACGTGGCGCGGCTGCGGGCCGGGGCGCCCGGTCAGCCGCCGCTCTCCGCGGCCTCGGCCGCCCGCGCGGCCAGCGCGGTCCGCGGCCTGCACCGGTTCGCCGCCCGGGAGGGGCTGGCCGGCGCCGACCCCAGCCGGGAGGTACGCCCACCCGTGCCGCCCCGGCGGCTGCCCCGGGCGCTGGACGTGACCGAGGTGCTGCGGCTGCTGGAGGCCGCCGGTCCCGCCGCCGAGCCGTCCGTCGAGCCAGCCGCCAACCCCGGTCCCGCCGGATCGGCGGCGCCGGCCGGACCGGCGGCGTCGGCCGGACCGGCGGCCGGGCTCGCTTCCACCGGCGGGCCGTCAGCCGCGGCCGGGCTCGCCTCCGCCGCCGGGCCGCTGGAACTGCGGGACCGGGCGCTGCTGGAATTCCTCTACGGCACGGGCGCCCGGATCTCCGAGGCGGTCGACGCGGTCGTCGACGACCTGGACCTGGCCGCCGGCACCGCGCTGCTGCACGGCAAGGGCGGCCGGACCCGGCTGGTGCCGGTCGGCGGGTACGCCTGCGCGGCGCTGACGGCGTACCTGGTCCGGGCCCGTCCGGCGCTGGCGGCCGCCGGTCGGGGCGTACCGGCGGTGTTCCTGAACGCCCGCGGCGGTGCGTTGTCGCGGCAGAGCGCCTGGACGATCCTGCGCCGCGCGGCGGTGCGGGCCGGACTGCCGGTCAGCGGCGGCCGGGCCGTCTCGCCGCACACCCTGCGCCACTCCTACGCCACGCACCTGCTGGACGGCGGTGCCGACGTGCGGGTGGTGCAGGAACTGCTCGGGCACGCCTCGGTGACCACCACCCAGGTCTACACGCTGGTCACGGTGGAGCGGCTGCGCGAGGTGTACGCCACCGCGCACCCGCGCGCCCGCGGCTGACCGGTCCACCCCGGACACCCGGCCTGACCGGGCCTCCCCCAGGGGGTCGGGTGTCCGACACGCCGGTACGGTGTCTCCGTGGCCCCGTGGGGTTGGCGTACAGTCGGGATCTGCGCGGGCCTGTGCCGGATGACCGGGGGGTCCGTGGCGGCACCGGACGGGCCGTCCGGTGAAACCGGCGTCCGAGCAAGCGTCGGGAGGGGGCGGGGACATGGCTGGCAACGATGATCGTGCCGAGGCGTGGACCTCGACACTCCGGGAGCAGCAGTCCGCACTCGACCTGGGCGCCGAGTTGGGACCCGCGGACCCGGCCGCCTACACGGTCCGCAAGCCGATCCCGGAGCCGATGCCCACCGACCGGCACGGACCGGCCCGGATCATCGCGATGGCCAACCAGAAGGGTGGCGTCGGCAAGACCACCACCACCATCAACCTCGGCGCCGCGCTGGCCGAGTACGGCCGCAAGGTGCTGCTTGTCGACTTCGACCCGCAGGGCGCGCTCTCGGTCGGCCTCGGGGTGAACCCGCACAACCTCGACCTGTCGGTCTACAACCTGCTGATGCAGGACGACGTCACCGCCGAGGACGTGCTGATCAAGACCGACGTGGCCGGCCTGCACCTGCTGCCGGCCAACATCGACCTGTCGGCCGCCGAGATCCAGCTGGTGAACGAGGTCGCCCGCGAGATGGCCCTCGCCCGGGTGCTCAAGTCGATCCGCAAGGAGTACGACTACGTACTCATCGACTGCCAGCCCTCCCTGGGTCTGCTCGCGATCAACGCGTTGACCGTCGCGCACGGCGTGCTGATCCCGCTGGAGTGCGAGTTCTTCAGCCTGCGCGGCGTGGCGCTGCTGCTGGACACCATCGACAAGGTGCGGGAACGGCTCAACTTCGACCTCGAACTCGAGGGCATCCTGGCCACCATGTACGACAGTCGGACCACGCACTGCCGGCAGGTGCTGCAACGGGTGGTCGAGGCGTTCGGCGACAAGGTCTACCAGACCGTGATCACCAAGACGGTCAAGTTCCCCGAGTCGACGGTCGCCGGTGCGCCCATCACCACCCTCGACCCGGCCTCCTCCGGCGCCCGTAACTACCGGCAACTGGCCCGCGAGGTGATCGCCGCGCAGGCCGAGCGGTAGCCGCCGGTGCGCGGAGCCCTGGAGCCCGTCGACTACGGTCGTCGGGTGACCACGTCCGCCGAAGCCGCGGTCCCGCCCGGTGAGCAGGCCGCCGAGGCGGGCTTCACGGTACGGCTGGAAAACTTCACCGGCCCGTTCGACCTGCTGCTCCAGCTGATCGGCAAGCACAAGCTGGACGTGACCGAGGTCGCCCTGCACCGGGTCACCGACGAGTTCATCGCGTACATCCGGGCCATGGGCGACGCCTGGGACCTGGACGAGGCCAGCGAGTTCCTGCTGGTGGCCGCGACCCTGCTGGACCTCAAGGCCGCCCGGCTGCTACCGGCCGCCGACGTGGAGGACGAGGAGGACCTCGCCCTGCTGGAGGCGCGGGACCTGCTGTTCGCCCGGCTGTTGCAGTACAAGGCTTTCAAGGAGGCGGCCGCGCACCTGGCCGGCCTGGAACGCGCCCGGCGCTACCCGCGGGCGGTCACCCTCGAACCCCGGTACGCCGAGGCGCTGCCCGAACTGGTTCTCGGGATCGGCCCGGAACGGCTGTTGAAGCTGGCCGTCCGGGCGATGACCCCCAAGCCGGTGCCGACCGTCTCGATCGACCACGTCCACCTGGTCCGGGTCAGCGTCCGGGAACACGCGGCGCTGCTGCGGGACCGGCTGCGCGGCCTCGGCAGCGCCGGCTTCCAGGTACTCTGCGCCGACTGCGAATCGACGCTTGAGGTGGTGGCGCGGTTCCTGGCGCTGCTGGAGCTGTACCGGGAGGGGCTGGTCGGCTTCTCCCAGGAGCAGGCGCTGGGCGAGCTGACCGTGTTGTGGACCGGCCCGGCCGACGGCGGGGTCGAGCTGGACATCGACGAGTACGCGGGCGCCCCGCCGGCAGCCGACGGTGCCCGGGAGGTGACGTCCCCGGACGGTCCGGCCGGCCTGTCCGGTCCGGCCGATTCGGCCGGTTCGGCCGGGGACGCGCCGGCGGGCGGGGGAGAGGGGACCGAGTGAGCCAGGAGAACCGGCCGGACTCGCTGGCCGAACAGGCGGCGGCCTGGATCCCGCCCTGGGCCCGGCCCGAGAGCGCCCCCGACGAGCCGGCGACGGCCGCCGGCGAACCCGACAACTCCGCCGGCGAGCCGGACACCGTCTCCGACGACCCGGACACCGTCTCCGACGAGCCCGAGACCTCCGCCGGCGGCCCGTTCGTCGGTCTCGACGCTCCCGACACCTCCGCCGGCGACCCGGTGGCCGACGTCGACGGCGGCGAACCGTTCGTCGGTCTCGGCGATCCGACCCTCGTGCCCGACGTGCCCCCGGCGTTGGGTGGTCTCGACGATCCGACCCTCCCGTCCGGCGTGCCGCCGGACGCCGCGGAGGAGCCCGTGGCCGGCGCCGCGGAGCCGGCCGACGCGCCGGCGGTCGACGCCGGGCCGGCGACCGGCATCGCCGATCCGACCCTCGACCCCGGTCCGCCGGTGGTGGCCGAGCCGGCTCCGGACCCGGCCGAGCTGGCCCCGGACCCGGCCGAGCTGGCCCCGGCCCCGGCCGAGCTGGCCCCGGCCCCGGCCGAGCTGGCCCCGGCCCCGGCCGAGCTGGCCCCGGCCCCGGCCGAGCTGGCCCCGGCCCCGGCCGAGCCGGCCCCGGACCCCGCCGGGCCGGTGGCGGACGAGCCGGCGATGGACGACGCCGAGCTGCGCTCGGCGCTGGAGGCCATCCTGCTGGTGGTGGACGAGCCGGTCGCCGACACCGTGCTGGCCCAGGTACTCGACCAGCCGACCGCGCGGGTGGCGGCGATGCTGGGTACGATCTCGGCGGGCTACACCACGGCCGGGCACGGCTTCGACCTGCGCCGCGCGGCCGGGGGATGGCGGCTGTACACCCGGCCGGAATACGCCCGGTACGTCGAACGGTTCATCCTCGACGGGCAGTCCGTCCGGCTCACCCAGGCCGCGCTGGAAACCCTGGCCGTGGTTGCCTACAAGCAGCCGGTGACCCGCTCGCGGATCTCGGCGATCCGCGGCGTGAACGTCGACGGCACCATCCGTACGCTGGTGTCCCGGGGGTTGGTCGAGGAGTGCGGCGTGGAACCGGACAGCGGGGCGTTCCTGTACCGGACCACGACGATGTTTCTGGAGAAGCTTGGCCTGGACTCGGCCGACCAGCTGCCCCCGCTGGCGCCGTTCCTGCCCGACGATGTGGAAGAGATCGACGATGTCCCTCGATGA

Protein sequences of DBSCAN-SWA_1

>NZ_CP022961|2689769:2698477|2694007_2695129_+|WP_095564888.1|DBSCAN-SWA
MPDGPDPAAGTAPEPSPALRRAVRGYLDHLTVERGLSANTLSSYRRDLARYLAGLAADGIGDLAAVGPADVAAHVARLRAGAPGQPPLSAASAARAASAVRGLHRFAAREGLAGADPSREVRPPVPPRRLPRALDVTEVLRLLEAAGPAAEPSVEPAANPGPAGSAAPAGPAASAGPAAGLASTGGPSAAAGLASAAGPLELRDRALLEFLYGTGARISEAVDAVVDDLDLAAGTALLHGKGGRTRLVPVGGYACAALTAYLVRARPALAAAGRGVPAVFLNARGGALSRQSAWTILRRAAVRAGLPVSGGRAVSPHTLRHSYATHLLDGGADVRVVQELLGHASVTTTQVYTLVTVERLREVYATAHPRARG
>NZ_CP022961|2689769:2698477|2697694_2698477_+|WP_095567755.1|DBSCAN-SWA
MADPTLDPGPPVVAEPAPDPAELAPDPAELAPAPAELAPAPAELAPAPAELAPAPAELAPAPAEPAPDPAGPVADEPAMDDAELRSALEAILLVVDEPVADTVLAQVLDQPTARVAAMLGTISAGYTTAGHGFDLRRAAGGWRLYTRPEYARYVERFILDGQSVRLTQAALETLAVVAYKQPVTRSRISAIRGVNVDGTIRTLVSRGLVEECGVEPDSGAFLYRTTTMFLEKLGLDSADQLPPLAPFLPDDVEEIDDVPR
>NZ_CP022961|2689769:2698477|2689769_2691464_+|WP_095564886.1|DBSCAN-SWA
MASARTIRHIFVTGGVASSLGKGLTASSLGNLLSARGLRVVMQKLDPYLNVDPGTMNPFQHGEVFVTDDGAETDLDVGHYERFLDRDLSGKANVTTGQIYSDVIAKERRGEYLGDTVQVIPHITNEIKSRILALGDPDEDGRTPDVVITEVGGTVGDIESLPFLEAIRQIRHDLGRDNCFYLHVSLVPYLAPSGELKTKPTQHSVAQLRNIGIQPDAIVCRSDREIPDKLKHKLSLYCDVDAEAVIACPDAPSIYDIPKVLHAEGLDAYAVRRLGLSFRDVDWTSWDDLLERVHRPRHTVRVALVGKYVDLPDAYLSVSEAIRAAGFGHRARVELRWVPSDDCVSPTRAAAALAGVDGIVIPGGFGVRGIEGKIGAARYARENGIPILGLCLGLQCMTIEVARHLAGLDGADSLEFDEQAVHPVIATMADQEDIVAGRGDLGGTMRLGAYPAVLTEGTIVADAYGRTEVSERHRHRYEVNNAYRDVLTKAGLRVSGTSPDGRLVEFVELERDLHPFFVATQAHPELKSRPTRPHPLFAAFVRAVVAYSEADQLPVELDPAGSPS
>NZ_CP022961|2689769:2698477|2692876_2693992_+|WP_095567754.1|DBSCAN-SWA
MKVGVPREVKNHEYRVAITPAGVNEFVRAGHQVCLETGAGAGSSITDAEFAAAGATILDTADEVWATADLVLKVKEPVAQEYHRMRPGQVLFTYLHLAASKECTDALLDRGVTGIAYETVELPDRSLPLLAPMSEVAGRLAPQVGAYHLQRPGGGRGVLMGGVSGVYAAKTVVIGAGVSGMNAAAIALGLQAEVLLLDKNVARLRQADAIYRGHLQTVASNAYEIERAVLDADLVIGAVLVPGAKAPTLISNELVSRMKPGSVLVDISIDQGGCFEDSRPTTHAEPVYPVHRSLFYCVANMPGAVPHTSTYALTNVTLPYALELANHGWREALRRDPALALGLNTHDGQVTYGPVAEAHGMTSAALADVLG
>NZ_CP022961|2689769:2698477|2691544_2692054_+|WP_095567753.1|DBSCAN-SWA
MPGGGVADRDYVRHVGSVGVVALDERGQVVLIRQYRHPVGRIMWELPAGLVDVAGEDLAAAAGRELAEEADLLAGRLDTLVDLHTSPGFSDEAIRIFLARELSEVPPDRRHDRRDEEAELSVVRLPLERAVAMVLSGEITNAACVAGVLAAARARDADWAPLRPSDAPR
>NZ_CP022961|2689769:2698477|2696276_2697260_+|WP_095564890.1|DBSCAN-SWA
MRGALEPVDYGRRVTTSAEAAVPPGEQAAEAGFTVRLENFTGPFDLLLQLIGKHKLDVTEVALHRVTDEFIAYIRAMGDAWDLDEASEFLLVAATLLDLKAARLLPAADVEDEEDLALLEARDLLFARLLQYKAFKEAAAHLAGLERARRYPRAVTLEPRYAEALPELVLGIGPERLLKLAVRAMTPKPVPTVSIDHVHLVRVSVREHAALLRDRLRGLGSAGFQVLCADCESTLEVVARFLALLELYREGLVGFSQEQALGELTVLWTGPADGGVELDIDEYAGAPPAADGAREVTSPDGPAGLSGPADSAGSAGDAPAGGGEGTE
>NZ_CP022961|2689769:2698477|2695340_2696270_+|WP_095564889.1|DBSCAN-SWA
MAGNDDRAEAWTSTLREQQSALDLGAELGPADPAAYTVRKPIPEPMPTDRHGPARIIAMANQKGGVGKTTTTINLGAALAEYGRKVLLVDFDPQGALSVGLGVNPHNLDLSVYNLLMQDDVTAEDVLIKTDVAGLHLLPANIDLSAAEIQLVNEVAREMALARVLKSIRKEYDYVLIDCQPSLGLLAINALTVAHGVLIPLECEFFSLRGVALLLDTIDKVRERLNFDLELEGILATMYDSRTTHCRQVLQRVVEAFGDKVYQTVITKTVKFPESTVAGAPITTLDPASSGARNYRQLAREVIAAQAER
>NZ_CP022961|2689769:2698477|2692282_2692603_-|WP_095564887.1|DBSCAN-SWA
MTDPYQQQPGYPQQPGYPQQAGYPQQAGYQHPMGVSDKSKVVAGILGILLGGFGAGRFYMGDTKTGVLQLVVSFCTCGLGYLWGFIDGILILVNGGVDGQGRPLAD

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095564886.1|2689769_2691464_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.3e-138	47.8
WP_095567753.1|2691544_2692054_+	NUDIX hydrolase	NA	NA	NA	NA
WP_095564887.1|2692282_2692603_-	TM2 domain-containing protein	Q854V8	Mycobacterium_virus	2.7e-05	40.0
WP_095567754.1|2692876_2693992_+	alanine dehydrogenase	NA	NA	NA	NA
WP_095564888.1|2694007_2695129_+	site-specific tyrosine recombinase XerD	A0A0K2CP59	Brevibacillus_phage	1.0e-19	34.1
WP_095564889.1|2695340_2696270_+	ParA family protein	Q8JL10	Natrialba_phage	3.2e-19	35.1
WP_095564890.1|2696276_2697260_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.6e-08	27.3
WP_095567755.1|2697694_2698477_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	6.3e-08	30.1

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP022961|4314164:4380006|DBSCAN-SWA
GATGAGTGTCACATACACCGCTGTCCTGCCGGTACGCGAACACACCGTGGGCGTACTCGCCGGTCTGCTCACCACGGAACGCGCCCGCCGCGGTACCCGTGCCGGAACCCGCGCTCTGCCATGCCGTGACCAGGCGGTCCTGATCCTGCGCTGGTTCCTCGACAGCACGCGGATGCGGCAACTCGCCCGGGACAACGCGATCAGCCTCTCCACCAGCTACGACTACCTCCACGAAGGCATCGATGTTCTCGCCGCCCGGTCACCGACCCTGCACGGCGCCCTACTCGCGGCGAAGGCCGCCGGCCATGACTACGTGAACATCGACGGGATTCTGGTCGAGACCGACCGGTGCCGCACCCCGGGCCCTACGGAGGGCGTCGACCTGTGGTGGTCCGGTAAACACGACAACCACGGCGGCAACGTCCAGGTCGTCACCGTGCCCGACGGCTGGCCGATCTGGACCTCCGGTGTGCGGCCCGGCCGCGAACACGACACCACCGCCGTCCGCACCCACGCCGAGATCCTGCCCGCCCTCACCGCCGCCGGCTCCGACCTGCGCACCCTCGGCGATCTGGGCTACGAGGGCGAGTCCGGCACCATCACCGTCGCGTTCAAGAAGCCGAAGAACGCCAAGCTCAGCCTCGTCCAGCAGCAGCTCAACAAGGCCCACAACAGCCTGCGAGCGATCGCCGAACGCGGCAACTCGCTGCTCAAGATGACCTTCAAGGCGCTGCGCAACGTCAGCCTCAACCCATGGCGGATCGGCAAGATCGTCGCCGCCGCGTTGGCCGTTCTCCACATCGAGCACGACCGCACTACATGACAACCCTCAGTAGTCAGAACCTTGCACGGAATGGCTCAGTGGAACAGGCCCCAGTGCCGTTCCCGCCTGAACCAGGGACCTTCGATGTCCAGCAGCCCGAAGGCGACGGCAGTCGGCCGGCCAGGCGCGTGGGAGTACCGTGCGACGACATCGGCGTCCAGCTCGGTCGGGTCGCCCATCGGGACCGCGAACTCGAACAGTTCGTCGTGGTCGCCGACCCTTCGACGATCGAGCCGGTAGTAGCCCGCGTTGGCAGGGTCGACGGAATACTCGAACTCTTCGTTGCGCCAGCCAGCCGGCCCGTCGAACGCGAAGTAGTCGTCCGTTGAGCCCGGCGCGACGAGCGTCGGCAGCGTGTCCAGGAGCATCACCTGGTAGTCACCACGCGGCAGCCGGGCTGCGAAAGCATCGATGACTTCCTGGTCGAGCCCGTCCAGCCCGGCGTTGAGACGATCTCGTACGGCGGTCGCCGACAATGGTCCGCGCGGAGCGCCGGGCTGGCGGCGCAGGACGAGCCCGCAGGTGCCGCACGAGTAGCCGATCTGGTAGGCGGCAACGCCGTCGATAGTCAGGTAGCGACTCGGCATCCTGCATCCATCGACTCCGATCTGAGGACTGGCGGTACCGAGCGTCATCAGTTCGTGAGCGATGAGCTTCGTCATACGCCGCCGAACACGCACAGCGACAGCTCCCACGGGTGGCCGAACGTACCGAACCGGAAGCCCTCGGCGAGGTAGATGGAGTAGTCGCCGTCGGGGTACGGAGACAACGGCCAGCCGGGCCGGCCCGGCGGATCGATGTTCTCCGGTCCGACGAGGCTGGGCCAAGCCCGGGCCGGCTCGGTGATCGCCGGAACACGGTGCATGCTGGGCCGGAAGTCGAACACCGCGTTGACGCGGTCCCAGACCGCCTTTTCGTCGCCGGTCAACTCGCGGTACGCCCTCGTCGCCATCCGTTGCTCACACTCCAATCAGGCGTGGTAGTAGTCGGCGTACGAGGACACCTGTCTCTCCACCGAGAAATCAGCGAAGCCCCCTGCCGCCTCACTACGACCGAGGTGATCCAGCGCCTGCACGGCGTCTTCGGAACCCACCGTGAGCAGGTATCCCTTGGTTTCGGCCAGCCCGCCGCCGCACAGCAACTGGACGTCGACCGAGCAGAACGCGTCCCAGCTTGACGACTTCGCCCGCCAGATCGTCAGGACGTCGCTCATCACGCCGGCGTTGAACAGCTGGACGCAGCAGAGCTTCATCACCTCCGTGTCGCCGTAACCCTGACTCTGCCGCTCACGCTCGGTCTGGGCCGTGAGCAGGTCGCGGATCTGATCGAGGTGTTCCGCGGCTGGTTGCAGGCCGTAGCGGTGCAGGAGCTCATCCTCGTTCACTTTGACCACGTTCGTTCAGCTGCCGGGCCGGAACTCGTGGACCACCTCGATCAGCCCAACGATGTGCCGGTTGAACTCGTCGAGTTCCTCGGCGGGCACCCACAGCTCGAGGATGTCGCGCCCGCCGGCCTGCCGGACCGGGTAGCGGGAAGCGAACTCGCGGTCGACCTCGAACCGGGTCACGTAGCCGATGCCCGAGGCGGGGACGTTCCAGTCCCGGGCGATCATGATCGCGTACTGCTCGTTAAGGACCGGGTAGAAGATCGGCTGGTCGGGCAGCCGGGGCGGCCACGCCTTCCAACCGGAGGCCCGCACGAGTTCCAACTCCTCGGGGCCGGTCGGCCGCCACAGAATCGTCGTCTCGGCCATCGCGGCACTCCTTTCCGGCCGGCGAACAGTACCGGCCGACCCACGTGCTGGACCAGCCGATTTCCGTCCTCAATGCCGTACCGGCCAGTCGAAGCCGGACGATCTGGACCTGGGCGAGCACGATTCCGGTGCCGGTGTCGTGGGCCGAGAGCAGATGGACCCGCCGCCCGTCGGACAGCCGGGCGCCAGGGGCGACCTTCCCGTCGACGGCGATGACCCGACGCCGCCAATGGTCGACAGCCGGGACCGGTACTGTCCGGCCCCGTAGCCAACCGCGATGCGACGCATCCGGACGCTGGCCTACGTGATCCTGGACGGCACGCTGATCCCGATCGACCGGGTCGCCGACCAGCGACCGTACTATTGCGGCAAGCACAAACGTCACGGCGTGAACGTGCAGGTCATCGCGGATGCCGCCGGCCGGCTCGTCTGGGCATCACCGGCCCTGCCCGGTTCGACACACGACCTGAGCGCCGCCCGAACCCACGGCATCATCGACGCCCTGACCAGCGCGGACGTGCTGACCTTCGCCGACAAGGGCTACCATGCAGCCAGCGGAAGTGTGCGCATGCCGTTCAAACGGCACCGCTTCCGGCCGAAGCTGTCACACCGACAGAAGGCCGTGAACCGGGCCCACGCGAAGATCCGCGCCCGCGGAGAACGCGCGATCGCCACCCTCAAGACCTGGAAGATCCTGGTCAAGCTGCGTTGCTGCCCACGCCGTGCCACCGCGATCGTGCAGGCCATCCTCGTCCTGCACCACGTCGAAACCAACCGCTTCCCACGATGAAAATGGCTCAGTGTTGATGACATCAGCGGGTGCGGTCCTGTTCTCGATCACAGTTGTCTTCGCAAACGCCATGATCATCGACGGGCCGCACCCGTCCTTCATGGACCCAGCCCTACAGCAGAACCATCCAAAATCCCAGCTCACATAGCCCTCAACCGACTACGCAACGGCCCTGCGCAACAGTCCTACGCGAACTGCAATACCTACTCGCGACCTGGCTCGGATTCTGCCCTCTCTGCCACCAACTCGTCCCAACCCAACAAAGCACTACTAGTAGGCTGATCGATCGTTGGCTGTTTAGGAGGAGAAGTGTGGTCGGAGGGTAGCCGAAAGGTCCGACTGTCTAGTGTCGGACTCTGGGTGGCCGTTGCTCTCGTCGCAGCAGCGCAGGTGGCGGGGACACTAAACCATCCCGCTCGGGACCGCTTGGCGGATCTACACGTCTACTGGGGCTCGGTGCAGATGCTCTTGGACGGGGGCAGCCTCTACGACTTCGCCGCGTGGAACGATGCTCCCTTCACCTATCCACCGTTCGCCGGGCTGTTGCTCGCACCGCTGGGTCTGCTCGCTGAAGACCCAGTGCGCATCCTGTGGACGGCGGCAACCCTCGGCGTAGTAATCGGCCTGGCGGTGCTCGCCCGACACGGGGAAGGGCTGCGTATGGTCAAGCCGACGCTGTGCGTGCCGGTCGCGGCACTTCTCATGTTCTCCTCAGCACCAGTGTCGAGCAACCTTCGCTTCGGACAGGTCAGCGTAGCGTTAGTGGTTCTAGTCCTGGTCGACTGCCTCAACATCACGCCCGTCCGGTACCGCGGCCTAGCGACTGGCATCGCGTCGGCGATCAAACTTACCCCTATGATCTTCGTGGTGTATTGGTGGATCTCGGGCCAGCGGCGTACTGCAGCCAACGCCATCGCAACGTTCAGCGCTTGCACGGCCCTAGCCTGGCTTGTCCTGCCACATGAGTCGCTCCGCTTCTGGTTCACCGAAATCTGGAACGTCGATCGCGTTGGCAACATCGCAACCGGCGGCAATCAGTCCCTGAACGCGGCCCTTCTTCGCCTTGGAATTTCGGATAGCTGGCGGATCGTGCTGGCGGGCGTGATCGGCCTAGCGATCGTGGCAATTGCCATGGTGCGGGCCTCACGCGCCTACCGTAACCGGGAGCCGTTTGCCGCAACGGTGATCGTCGGCGCCGCCGGACTGGTCTTCTCTCCAGTGTCCTGGACCCATCACCAAGTTTGGCTGGTGCTGGCTGGTCTGCTCGCGGTTGGAAACCGGCGCGGCACGATGATCTGGTTCGGACTGGTGACGGCTTTGATGGTCCTGCCCATCACGTCACTCGGCGCAGGGCTGCCCACAGAGGTCCTTACCAGTAACGCCCGGCTACTGCTCGCCGTCGCCGTGGCATGCGCGGTGCCGTTCGCCGCTCTGACCGTGCGACGGGCGGACGACGTCGCGACCCCCGCAGGGCTGTCCGTCAACCAGGCTGCGGACTGTGCGGACGCAAGATGCAAAGCCACCAGGCACACGAGACCGCCTACTACCGTTGCCGCTATCCCAACGAGTACGCCCTCGCCAACCACGTCCAGCACCCCGGCAACGTCTACGTCGCGGAACGAGACATCGTTCCCGCCCTCGACAACTGGCTCCTCAAAGCCTTCGCCCCGCACCGGCTGACCGATACGATCCGCCGGCTCCACGCCGCCCAACCCGCCGCCGGACCAGCACCGTCGCGCCAGAGATCACCGCTGCGAGCCACGCCTATCCCGGCATGTGCGGCCACCAGCAGTCAACGAGCCGGCGGAGGCGGCATGGCGGCCAATCGACCTCGCCATCGACAGCTTCGAACCGCTCGGTGCCCAGCAGACGCCCTGGCCGCAAGACCGGTCGACCCTCTACTGGTGGCGGCCAACCTTCTGGCGCGCACCCAGCCGTCAGGGTCGACGGATGGCTCAGCACGTCGCGGAGTTCACAGGTGGGCGCTCCGGGCAGCATCACGACGACCTGCCCCTCTCGTACCGCGGACTGACGCCCCTGCCTACTGGTCGCCGCAACACGCCCACGACCCTGGCAGCGATCTCACCTCCGACCTGTGCGTCATCGGAGGCGAGCACTTCTTCATCCAGGGCAACGTCGAGGTTCCCATCCTCGGCTCCGACCGCGTCTTCACCTGGGGCGTCTGGGTTTCGCTGAGCAGCAGCAACTTCTCCCGCGCCGTCGACCTGTGGGAGCAGCCCGGTCGGGAACACGAGCCGGCGTACTTCGGCTGGCTGGCCACCGAGCTGCCCCTCTACCAGCCCGAGCACGGTCGAGCTGAAGACGAACGTGCACACCCGACCGGTGGGTGAGAAGCCGTTCGTCGAAGTCGAACCCACCGATAATCCCCTCGCCGTGGAACAACGCACCGGGATCACCATGGACCGCGAACGGCAGATCGCCCCGAACACGCTGTCCACCGCGCGGCCGGCCGAGATGCTGGGCCGGGCCGGGCCGGGCCGGGCCGAGTCTAGGCTCGGCGGTCGTAGCAGCGTTCGACCCCGACGCGGACCCGAGCTCCGACCTCGCGCTCCGCCTGATGATCAACGCTCCGGTGACGCTCTACTGGCGCCCGACGTTGCTGGACCAGACCATCGCCTGGCTCGACCAGCACGGCTACCAGATCGTCCAACTCGACGCCGCACGCTGGGAGACCGAGGACGACCTGCACCGCGACGTCGCGGACGCGTTCGACTTCCCCGACTACTACGGGCACAACCTGGACGCCCTCCGCGACTGCATGAGCGACGTCACCGACGGCGAGTACGGCTGGAACACCGACCGGACGGGGTTGGTGGTCGTGTTCCGCGGCTACGACCGGTTCGCTCGCTCCTGCCCGAGGGCGGCGCAGCTGGTGCTTGACATTATCGCCGAACAGTCCAGGACGGCCTTGCTGTTCGGCCGCCGCGTCATGTGTCTGGTCCAATCCGACGACCCCGACATCCGGCTCACCCCAGTCGGAGCGACACCCGCGGCGTGGAACGACGCCGAGTGGCTCGACAGCGCCCGTCACCCCGACCGCTGACCAACCTTCGCCGGCCTCAGCCGGGCCGCTCAGTGTCCAGCCTCGCGATGCCGCGAAGCAGCCCGGCCAGATGCGTCAGGTCGTGCCACAGGACCACCGGCTCATCCACTGCCTGGCCAACGATCTCACGGATGGAAGCGACGTCGTCAACCAGTGACGCGACATCCACCGACGCCACAGACTCCGAAACAAGATCAAAACTCTCCGTAAGGCCGACCGACCAGTAGAAGTCACCCGTAAACCGGATTTCCTCACCGAACCGGACCTCGATCGCGGCCAGGAGCCGCTCGATCGCGTCCCGCAGCTCGGCCACCCTCATCGTCGGTACATCAGCCACCACCAGATCATCCAGCACCCCAACGGGCTCGGCATGGCAGTTTCCGCGGGGGCGATATGACGCTGCCGGCCACCATATTGCGTGGATAGGGTAGCGGCGTGACAGCAGCGCTGGAGCCGACGGGTCCGTTCCGCTGGGACCTCGTCTCCCCGGACCAACTCGGTAGCCTCCTCGACACCACTCCCGAACCGAACCTGTGGTTTTTGCCCGACCTGATCGAATGCGCCGGTCGGGTCCTCGCGCGCAGCGCCAACGCCGACCTCTACTTCGTCGGCCGCTCCCCCGACAGCATCTTCGACCTCCTCACCGGCGCCCTCGCCGGCACCACATGGCGCAACCGCTGCCAACGGCTCCCGCTGTCGCTGTGGAGCGACCCCGATGCCCTGACCTCGGCACAGGTCACCCAGTTCCGCACCAACCTGGGCCATCTCGGGATCACCCCGCACCACCTCGCCCACCGCCAGAAGCCCGTCGCGTTCGTCGACCTCGTCCACGGCGGCCGCACCTACCAGAACCTCTTCCACCTACTCCGGGGCTGGATCAGCGAGGAGCGGGCCGCGTGGTCGGTGATCCGCACCAAACTGCGGTTCATCGGCATCACCGCCCGGACCAAAACCAGCCCCAACACCTGGCGCTGGTACCAAGCCGCCCCCTGGGCCGCCTACCTCCCCCGCAACGCCCTGGTCAGCGTGTCCCTGGGCCAGCGGGTATGGGGCTACCTCGCCGACCACCAGCACAAGATCACCCGCTCGTTCCCCGTCAACCGCTGGCTCGACCAGGACACACGCCTGCCGGCACGCGACCCCACAGCACTGGCCGCACTCGCCGAGGCCGTCTCCCTCGTCGCCCACGGCCGCTCCCCCGAAGGTCGCACCGCTCTGACCGCCGCGATCACCGACGAACCGACCATGCACCAGCCATGGCTACGCTTCTTGGTCACCGAGCTTCGCCGACCAACGACCAGCCGCCAGGGCTAACCAGCCAGGCCGACCGCCCCAGCGGCGAGGAAACCCGGCTGCAGCCCGGTGCCCGTTAGGGAAGACTGGCGGCCGTTCAACCCCGTACCCTCGCCGAACTGACCGACCTCGTCGCCACCGGCAAACGAGCGAAATACCTCTACTTCTGGGGACACCAGGCACCCCGCGGCGGAGGAATCGGCGCCGCCTGTCTGAGCCAATGGTGGTCAGCCCGGTTCACCATCGACGGGCGCACGTTCGCCACCGCCGAGCACTACATGATGTGGGCCAAAGCCACACTGTTCGGCGACACCACCACCGCCGACCAGATCCTCACCGCACCCCACCCACACAAGGCAAAGACGCTGGGACGCCAGGTCCGGCGCTTCGGCCAACCCAGCTGGGAAACCCACCGGTACGCCATCGTCGTTGACGCCAACCTCGCCGAGTTCAGCCAACACCCCGACCTACGCGCCTACCTGCTCGGCACCGGCACCCGAATCCTCGTCGAAGCCAGCCCCGTCGACCGGATCTGGGGTATCGGACTCGCAGCCACTCGTCGTGCTGGATACCGAGGAACCAGTCGGCGTAGTCCGTGGGGGCTGAGGGATGCCAGCGGGCGCCTTCGGTGTCGGTCGCCCAAATGCCGTTCGGATCAGCGTCTGCATTGGGTATGGCGGGCAGAACGTCCATATGAAACGGCAACAGGTCGTGGACGAAGGTCCATCGTCAAGGGTGAGCTTCAGGTCCGGGCGCTCCTTGACGAATTCTTCCAGCGCGTCGCCGACATCGGCCTTGAGGCCCTCCGGATCGATCTGCGACCTATCGAGGTCGTGTCGGCACACCATGTCCAGGTCGTACTCGTCCCGCCGGTGGATTAACGCTGTCACGGTGCCGAGTCGCATTGATCCCTGCGGATATGGTGCCTCGCCAGTCCCGCTTGCCGACCAGTAGGTGCTCAAGAAGTCACAGGCAGCCTTGTAGGCGGTCTTGGCGACCCTGAATTGATCTTCCGGGATGTCGAAAGACTCGATTCCCGCGCCCAGCACCCGGGTCAATTGATCGTCGCGATTCATGATTATCGTGGTTCCTCTCCGGTACGGAACAAGGGCCTCTGTTCGATGCGGACAGGATGCTGCCCGTCCTTGTTGAGGGCGAGACCGTACCGGGCGCCTACGACAGAAAAGTCGTGAGAAAGATCGTTTTCGGGCGTGGGACTGCTTCGGTGATTACGGTGCACGGCAAAGGATCTTCGTTCGCCCTCGCCAGGCTCGACTTGTGCCCCCGGATCAGACACCGGCCAACGCCATCGGCAAAGGGGAGTCGGGAAGAAACCAGTAGTGTCTATCCGGAATCGCGCCAAGATTCCCGCGGCCACCGCCGCCCGCCTTCGCGAGGCATAGACGATCGAGAACGTCACTGGAAACCGCCGCGGCCGGATGGCCGATCAGAGATCCCCAACAGGTGGAATCCGTCCAGAAGCTGGCAGGCGCCCGATGGTCTCTACAAGTGCGGCGCTGTGCAGCCGTGGTAGCGAGTCGGTCATCGGGCCGAAACGGTCGAGGATCGACTGCGACGCGCGTGCGCGCAGAGTGGTCAGCCTGACAAGTAATTTGTCGCTTATATCAACAACCATCTCCGTATACAGCTTTTTGCCTTACCGGCCAGATTTGTAGCAATCGCAGTGGTATATCCGACGCAGGCTGTAGTGGATATCAGACCCTGGATGGGAGGGGCGGCGGAGACCAGGGGATCGACGGCGGCTGGATGGATATCGTTAGTGGTGCGGACACCATGCTGGTTGGGCGAGCTTCGCCCAAGAGTCTCGATACAGTGAGCCATTCCGTGCAAGGTTCTGACTACTGAGGGTTGTCATGTAGTGCGGTCGTGCTCGATGTGGAGAACGGCCAACGCGGCGGCGACGATCTTGCCGATCCGCCATGGGTTGAGGCTGACGTTGCGCAGCGCCTTGAAGGTCATCTTGAGCAGCGAGTTGCCGCGTTCGGCGATCGCTCGCAGGCTGTTGTGGGCCTTGTTGAGCTGCTGCTGGACGAGGCTGAGCTTGGCGTTCTTCGGCTTCTTGAACGCGACGGTGATGGTGCCGGACTCGCCCTCGTAGCCCAGATCGCCGAGGGTGCGCAGGTCGGAGCCGGCGGCGGTGAGGGCGGGCAGGATCTCGGCGTGGGTGCGGACGGCGGTGGTGTCGTGTTCGCGGCCGGGCCGCACACCGGAGGTCCAGATCGGCCAGCCGTCGGGCACGGTGACGACCTGGACGTTGCCGCCGTGGTTGTCGTGTTTACCGGACCACCACAGGTCGACGCCCTCCGTAGGGCCCGGGGTGCGGCACCGGTCGGTCTCGACCAGAATCCCGTCGATGTTCACGTAGTCATGGCCGGCGGCCTTCGCCGCGAGTAGGGCGCCGTGCAGGGTCGGTGACCGGGCGGCGAGAACATCGATGCCTTCGTGGAGGTAGTCGTAGCTGGTGGAGAGGCTGATCGCGTTGTCCCGGGCGAGTTGCCGCATCCGCGTGCTGTCGAGGAACCAGCGCAGGATCAGGACCGCCTGGTCACGGCATGGCAGAGCGCGGGTTCCGGCACGGGTACCGCGGCGGGCGCGTTCCGTGGTGAGCAGACCGGCGAGTACGCCCACGGTGTGTTCGCGTACCGGCAGGACAGCGGTGTATGTGACACTCATCGTCGGCGCAGGACCTCTATGAAGTTGAGCTGTAGGAGGCCACCTTCTTATCGAGGTTCTGCGCCGTTCCTACGTAGCCGCGATCATCCGGCGCGTCTCCGACTTTCCACGCATCTCGTCGGCTACAGACAGCAACCGCAACGTTGCGCGGAATGGCTCAGTGAGCCTTTTTCATCCTGCGTGGCGGGCGGCTTCGACGTGGTGCAGGACGAGGATGGCCTGCACGATCGCGGTGGCGCGGTGTGGGCAGCAGCGCAGCTTGACCAGGATCTTCCAGGTCTTGAGCGTGGCGATCGCGCGCTCACCGCGGGCGCGGATCTTCGCGTGCGCCCGGTTGACCGCCTTCTGCCGGCGTGACAGCTTCGGCCGGAAGCGGCGCCGCTTGAACGGGGTGCGCAGGCTGCCGCGGGCGCCCTGGTAGCCCTTGTCCGCGAAGGTCATCACGTCGGCGCTGGTCAAGGCTTCGATGATGTCGTGGGTGCGGGCGGCGGTCAGGTCATGCGTTGAACCGGGCAGCGCGGCCGATGCCCAGACGAGACGCCCTGCCGCATCCGCGATGACCTGCACGTTCACGCCGTGACGTTTGTGCTTGATGCCCCTATGTATGTCAAGCCGTAGAGGGCTGTGGCGGTGTTGTCGGGGTCATTGAGGCGATGATGATCCGGTAGATGGCGCGGGCGAGGTACCGCTTAAGGCAGCGGATGATCTCGCGTTTGGACAGACCCTCGGCGGTCCGTCGCTGCATGTAGTCCCGCGTTCTCGGGTTCCAGCGCAGTCCGATGAGCACGGCTCGGTACAGCGCCGCGTTGGCTTGGCGGTGGCCTCCGCGGTTGAGTCGTCGACGTTGGGTCTTGCCCGAGGACGCCTCGACTGGACTGACTCCGCAAAGGGCGGCGAAGGACGCCTCGCTGGCAAGCCGACCTGGGTTGTCGCCGGCGGCGATCAGTAGCGTGGCGGCTGTGTCGGGGCCGACGCCGCTGATCCGCAGCAGTTCTGGTGCTGTGGATTGCACCGCGCCCGCGATGCGGTGCTGCAGATCGCGGATTTCGGTCTCGAGGTGCTGGATGCGGCGGGCGAGCTGTCGTAGCGTGTACAAGCTTGCCGCAGTGACGGCGTCCTGGGCATCGACGTCGAGCTGGCAGCATCGCGCGACCAGCCGGGAAGTATTCAGCAAGGCGAGGGCTTCACGCAGTGCGGGCTCGGCAGTGACCACGATGGCCTTGAGCTGGTTGATGGCCTGGACACGGGCTTTGACCGCCGAATCTTTCGCGGTCTTGAAGATCCGCATCGCCTCGACCAGCCCGTCGGCGGTCTTCGGCAGCGCGGTCGCATCTCCGGCGAGGACGGCCCGGGCGGCGGCCTCGGCATCCACCGCATCGCTCTTGCCGCGCCGGCGCCGCACGGACCGGTCCGGCCGATTGACCTCGATGACATGCACGCCCGCTGCACGTAGCAGCCGGGTCAGCCCTGCCCCGTACGATCCCGTGCCCTCAACCCCGGCCAGACGCAGCGGGCCATAAGAGCGTGCCCACATCACCATGTCGCGGTAGCCCGACTTCGTCGTCGGGAAGTCTCGACCGGCCAGCAGCACACCCAACGTGGTCAGCACGACCGCGACGTGCACATCCTTGTGGGTATCGACGCCCAACACCACCTCGTGGTCGCCGGTCTCAGTCTGGCCTTCCTGCGGCATGATGGTCACGGCTGCTCTCTCATCGAGGAACGGAAACGGTGGCCGTCGCCGGGCCGGCGCCCGCGGTCAGGACTGTGACGGTGCCTTGTAACGGCAAGGCCCCTATCGGGACACGCCACGCCGGCTCGGCGGCAGCAAGCACCGCCACAGAACCCGGTCGACAGATCAAGCACAGGGCACCGACAGGGCCAACCAGAGTACGGGTCAGACCGAACCCCGAGGCGGCATACAGAGATTCTCACAGCCGGAGTAGTACGGCTTCTGGTCGGCGACCCGGTCGATCGGGATCAGCGTGCCGTCCAGGATCGCGTAGGCCAGTTGCCGGATGCGCCGCATGGCGGTGTCCAGGTCCTCGGCGGCAGCGCTGAGCAGGGCGATTGCTTCTTGAACATAGCGCCAGGCGGTCGCGACGCCGATCTCGAAGCCGGCGGCGAGGCGGGTGTAGGTGTCGCCGTTGCGCAGGTGGGCCAGGGCGAGTAGTGCCTGGCGGCCCGGGGTCAGCCGCCTCCACCGGGATCTGCGCTGCTGGCGGTGGCCGCGGATGCGTTCGGCGAGGTGGTTCAGGGCCTGGCTGGACAACGGGATCGTGGCAGGGTAGGACAGCATGGCGAGGCTCCCGGTCGGGGCATCGGGTCTTGGTCGATTTGCTGTCCTACCTGGAGCCTCGCCCTCATCGATCAGCACCCCCTGCCGACCCGGACTGACCTGCAAGATCAGATTGGAAAAGGCTCATCGAGGACCTCGAGAGCGCGTACAAGGCTCTGCGCGACGGGCGGCCGGTCCGGTTGCCCGCTCGGACGACCTCTTTCCGGCGGTGGTCGCAGGCGCTGCGCCGGCACGCGCTGAGCCGGCCGGTCTGCGACCAGCTGCCGTACTGGCAGGCGGTGCCCAACGGGGATGCGACCGCCGTGCCGGGCCGCTCTGGCGGCGCCAACCTGGTCGCCCAGCGCGCCACTGTGACTGCGGTCCTCGATGCGGCGGACACCGCCCGCCTCACATACGACGTGCCCCGTGCGGCCGGGGTGTCGGTGCACCAGCTGCTGCTGACCGCGCTCCTTGTGGCCTGGCACGGCGAGTTTGGCTGTACGGCGCTGCAGGTCGACGTCGAGGGCCACGGCCGCGAGCCGATCGACGCAGGCCCCGACGTTAGCCGCACCGTCGGCTGGTTTACCAGCGTCTATCCGGTCACGTTCGACATCGTGGCCGGTGGCGACCCCCTCGCCGTGCTGGCGGTCGTGCGCTCGCGGCTCGACGCGGTTCCCGACCGCGGCCTCGGCTACGGCTTGCTGCGCTACTGCGCCGACCCGGAGATTGGCGAGCGGCTCAGTGCACTGCCGCAGTCCCAGCTCAGCTTCAACTACCTCGGCCGCTTCGAGGGCCCGTCTGACGAAGGCGCGGTGTTCGGTGTACCGCTGGAGATCCCTACGGTGCTGCAGCGCCCCGAGGCGCCGCGGCGCTATCAGCTTGAGGTCGCCGCGACCGTGGCCGCCGGGCAGCTCACCCTCGAATGGGTCTACGGCACCGAGAGCCTCGACCAGGCCACGGTCCGGTCGGTGCTCGACCGGCAGGTCGCGGCGGTCCGCACGCTCGCCGAGCGGCTGCTGGCTGATCCCCGCGCGGCCGGCCGGTCCGGCACGCCGTTCCCGCTTGCCTCGCTCAGCCACGACCAACTGGCGGCCATCTCACGGCGGACGGTGGGACGGTGATCCTGATTGCGCGTAACCGCGCGTTCGGGCTGCTTTGGTCGTCCCAGGTGTTGTCCAATGTGGGCAACTGGTTGCTCGTCGTGGCTGTGCCCGTGTTCGTCTTCCAGCTCACCGGCTCGGCGCTGAGCACCGGACTCGCGTTCGTCGCCGAGACCGCGCCGGCGCTGGTTCTCGGCCCGATCGCAGGCGTGTACGTGGACCGCTGGGACCGCCGCACCGCAATGATTGTCGTGGACCTCTTCCGGGCTGCGGCGCTGCTGGCGCTGTTCCTCGTTCGCCAGCCGGACCAGCTGTGGCTGCTGTACCTCATCGTGTTCGCCGAGAACGCCGCCGGCCAGTTCTTCGGCCCGGCGCACCGGGCGCTCGTTCCGGCACTCGTTGGCCGTGGTCCCGACCTCGACCGTGCCAACGCCTGGTACTCGATCGCCAACGGGATCGTCCGCCTCGCCGGAGCCCCCTGGGTGGGGCGCTGCTGGTACTCACCTCGTTCCACACGGTCGTCGTGGCCGACGCCGCCACGTACCTGATCTCCGCGCTGCTCGTGCTGGCGGTCCGCCGCGTCAGCGTCCCGGCCGTGCGGGCCGAGGCTGATGAGACACCGGCCACTGGCGCGCTGGCCGAGTTCCGCGCGGGGGCGGCGTACCTGTTCCGCCACCTTCTTCTACGGGCGCTGCTGCTCACCTCCTCGTCGTTCCTGCTGGTCAACGCCGCATTTACGGTGCTGCTGGTGCCTTACCTGGTCGGCCGCCTCGGTGCCGACGGCGAGCAGGTCGGCCTGCTGCTGTCCGCGCTCGGCATCGGTTTTCTGATTAGCGCCTACGTCGGTCGCGCGATTTCCCGTAGCGGCCGGCTTCGCTACGGCGCCGCCGGCTGCCTCGCCGCCGTCACGGTCACCTTCGGTGGTCTATTCGGCTGGCACGACCTCGTCGCGGCAGCCGTCTTCCTGGCGCTGGCCGGCGTGCCCGGCGGCGCCTTCCTGCTCCTCATCGAGGTGCAGGTGCAGCGGCAGACCCCGGACCATGTGCTCGGCCGGGTAAGCGCAGCGTTCTCCAGCACAGAGATGGCCGCGACCCTGCTCGGCGGCCTCCTCGGCGGTGCCCTCGCCGCCGCCGTCGGGCTCATGCCGACGGTCGCCGTCCTGCTGATCCTCCTGGCCCTCGTCGCAGCCGCCGCCCTGGTCGTGCTGCCGGACAAGGTGGTGGCCCCAGATGCCGCACCGATCGAGCCCGAGAGGACATCCGTTGAGTGAAATCACCACTGGTCCGCTCACCTACGGCCAGCTGTCGCTGCTGCGCGGCCTGCAATACCTGGGGACCGACATGCGGCCGGAACTCAATGTCGGGCTGCTGTGGCCCAAACCGCCCACTATGGACAACGACGCCCTCGGCACCGGGCCGGTCGGTGCCCCCGGTGACGGCGAGCGCCGGCCCCACCGCCGCGAAGCGACGAGATCGCCACTGCGCTGCGCGCCCACGCCGAGGAGTCCTCCGGCCACCAACACCGCACAGCCGGGCGCTGCCGCCCACGAGACCACGCCACGCGCCATCGGTAAGAAGAACACCAGCCCGATGATCCCGAACGCGATCGACAGCCCTTCAGCGTTGAACCGGAACAGCCGTACCGGAGCGCTCTCCGACTCCCGGGCAACCTGCTGGCGAACAGCGTCGCGGAACGTACGGCGAAATGACACAGCAACCTCCCACCGTCAGAAACCTCGCTCGCGCCGACAGCCCAGACGCCGGGCACCAGCCGGACTGTCCAGTATCAGCACGGCAGCCATCTATGGAACGGATCGTCTACCGGCGAGGTGCCGGGTCGTACAGTGACCGGGTGCTTCTCACCTTCGACGTCGGCGTTACCGAGCGCCACCACGTGACGTTCTCCTTCAACAAGTTCTGGGGCAACCTGTCGATCAAGGTCGACGATGTCAGCGTCGTCCGGACAGTCCGGCTCGCCTCGATCGACCTCGTCAAACGCTACGAGTTCACGGTCGGCACGGAGGAACAGCACCACGTCCGCATCGAGAAGCACCGCGAGCGACTCTTCGCCGGATTCCGCCCACAACCGGTCTACGCCTACGTCGACGACCAGCTCATAGCCCAAGGCGTCGCATGACCAGCAGATTTTCAGGACGACGGCCCGTTCCATGGCGAGATAGCCACCGCCGAAGCACAGGCCCTCGGCGCGGACCATGGCCTGTCCAAGTGAACCGATACCTACTGAACAATTATGAAGGCAGGTTCATAACGGCACGGATGCCGTTGTCTGGCCTACCCCCGAAATTCCGCGCCGTTTGAGAGCTACTACTGGGTGGGATCCGCCGGGCGGTCGCGGAGTTGGATCTCGGCAGCGTTCTGGAGGTAGCTCTGGTGGGACACGGGCACGAGTACGGCGTTGTCGTGGAAGCCGCGTAGTGTGGTGGATCCGCAACTGATCATGGTTGCTTTGAGTTTGGCGATGGTGAGGGCGATGTTGTCGTAGAGGCTGCCGGCGTAGGGGACGTAGCCGTCGACGCCTTCTTCGAAGACAAGTTGGTTGCCGCCCTGGTCGTAGCGGGCCCAGTTGCGGGCGCGGCGTGACCCTTCGCCCCAGTATTCCTTGAAGAGTTGGCCGCCGACGCGAACGAGCCGGGAGGGGCTTTCGTCGAAGCGGGCGAAGTAGCGGCCGAGCATGATGAAGTCGGTGCCGAGGGCGAAGGCGATGGCCATGTGGTAGTCGTTGAGGAGGCCACCGTCGCAGCAGAGGGGGATGTAGGTGCCGGTGTCGGCGGCGTAGGCGTCGCGGGCGGCGACGACGTCGATGAGGGCGGAGGCTTGTCCGCGGCCGATGCCTTTCTGGTCGCGGGTGATGCAGATGGAGCCGCCGCCGATGCCGACCTTGATGAAGTCGGCGCCAGCGTCGGCGAGGTAGCGGAAGGCGCGTCCGTCTACGACGTTGCCGGCGCCGACGGGGACGCTGCTGCCGAGGTCTTTCTTGATGTGGTTCAGGGCGTGGGCCTGCCAGACGGAGTAGCCGTCGGAGGAGTCGAGGCAGAGCAGGTCGGCGCCGGCGTCGAGGAGTGCGGGGACCCGGTCGGCGTAGTCGTGAGTGTTGATGCCGGCGCCGACGCGGAACCGTTTGCTGTCGTCGATGGTCTCGGTCTGGAAGGTCTTGTGGAGTTCGTAGTCGCGGCGCAGGACGATCGCGTGAAGGCGCCCATCGTCGCCGATGATGGGTAGGACGTCGAGGCGGTGGTCCCAGATCATGCTGTTGGCCTCGGACAGGCCGATGGTCGGTGGGGCGGTGACGAGGCTGTCCGTGGCGCGCATGCGGGTGCTGACGGGCTCGGCGAGGTTGTGGCGCTTGGGGTGGAAGTCGTGGGTGGAGATCAGGCCGAGGAAGGTGCCGGTGCCGGTGCCGTCGTCGGTGACGACGGCGACGTCGCGTTCGGCCGCTTCGAGGAGGTTGGTGACCTCGCCGAGGGTGGCTGACGGGGTGGTGTTGATGTCGCTGTGGCGGAAGCCGGCCTTGTGGCGCTTGACGCCGCTGACCATCTCGGCCTGTTGAGCGATCGGCTGATTGTGGTGGATGAAGCCGAGCCCGCCGCACTGGGCGAGGGAGATGGCCATGCGCGGGGAGGAGACCGCGCCCATGATCGCGCTGACCAGCGGTGTCGCGATGCGGATGGCGGGTTCCTCGCCGATGCGGTGGCGGGAGAGTGGCGCGCTGAGGTCGACGTTGCCGGGCACGCAGTCCTCGGTGGTGAGGTTGGGTACGAGGAGGTATTCGTTGAGCGTGCGAGAGGTTTCGTCGAGAATCTTCACGCGTTCTCCTTGCTTGCTTCACACCGGTCTGTGAGGAAAGGAGCCGAGGCTACCAGTCAGGTGGGTGCGGGCACTGGTGGCCTCGGCGCCGTGTTTCCGCTGGTCACGTCGGCTTTTGTGGTGTCGGTGGGCTGGTGGCGGGTCGGGTGTCTCGTTAGTCGGTGAACGGGGCGAGGGGGTGTCCGGCAACGGCTTGGGAGACGAAGCCGTCGGGGCCGACAGGTCGGTCGCCGAGGATGGTCACGCGGTGCATGGTGCGGCGGACGTTGAGGTGGTTGAGGTCGGTCGCGGCGAGGTGAGCGGTGGCACGGTTGTCTCAGATCGCGACGGATCCGGCCTGCCAGCGGAAGCGGACGGTGTACTCGGGGCGGATGATCTGGGCGAAGAACACGTTGAGAAGGCGGCGGCTCTCCGCCGGGGTGAGTCCGACGATCCGGCTGACCGAGGCGGGGTGGACGTAGAGGGCGTGTTCGCCGGTTTCGGGATGAACCCGGACGACGGGGTGGATGGAGACCTGGGCGTCGGCACGGGCGCGAGCGCAGATGGCGATGTCCTCGGGGTCGGCTGGTTGTAGTTGGCAGCCGGCGAAGAAGGTGTGTTCGGCTTGGAGCCGGTCGGCGAGGGCACGCAGCGGCGTGGACAGACTTTGGTAGGCGGCGACGAGGTTGGTCCAGTGGGTGTCGCCTCCGAAGTCCGGGACGCGTTCGGCGCGCAGGATGGAGATCGCGGGTGGGTTGATCGCGGGGGTGAGGTCGGTGTGCCAGCCGGCGGTGTAGGTGGTCCACTTCTGCCGGTAGCGTTCCTCGAAGTCGCGTCCGTAGCGCTCGTCTTCGGCGTGCGGGTCGATGGTGAGGATCTGTGGGAAGCTCTTCTCGCACTACGGCGTCGACCTCTGGGTGCCCGAGGTCGGCGGCGCGATCGACCCCGAGTCCGAAGCCCACGACCTGATCATGAGCGTGATCGGCGGCATGTCCAAGGGCGAACGCACCCGCGTGAAGGTCCGCGTCCGCACCGCGATGACCTCGCAGGCGAAGATCGAGGGCCGCTTCCTCGGCGGGCGCCCGCCCTACGGATACCGCCTCGCCGACGCCGGACCGCACCCGAACCCGGGCAAGGCCGCCGACGGCCGCCGCCTGCACAAGCTGGAACCCGATCCAGCCACCGCGCCCGTTGTCCGACGGATCTTCGCCATGTACCTCGCCAACAACGGCTACTTCGCCATCGCCGAAGCGCTGACCCGCGACGGCATCCCTTCCCCGTCAGCCGCCGACCCCGCCCGCAACCCCCACCGCACCGGCCAAGGCTGGGCCAAGAGCGCCGTCAAGAACATCCTGTCCAACCCCCGCTACACCGCCGCCAGGTGTGGAACAAACAACGTAAGGACGAGGTACTCCTTGACGTCAACGACGTCGCCCTCGGCTACGAGACCCGGATGCGCTGGAACGACAAGGACTCCTGGGTGTGGTCCGACATGATCGCGCATCCGCCGCTTGTCACCGTCAACGACTTCGAGCTAGTTCAGAAAATCATGGCGGCCAGCGGCCGGGGCCGCACCGGCACGCGACAGCGGAAGGTGCGTCGCCACTACCTGCTACGCGGTCTCATGCTCTGCGGACTGTGCGGACGCAAGATGCAGAGCCACCAGGCGCACGAGACCGCCTACTACCGGTGCCGCTACCCCAACGAGTACGCCCTCGCCAACCACGTCCAGCACCCCCGCAACGTCTACGTCGCGGAACGAGACATCGTCCCCGCCCTCGACAACTGGCTCCTCAAAGCCTTCGCCCCGCACCGGCTCACCGATACGATCCGTCGACTCCACGCCGCCCAACCCGACACCGGCTCCAGCACCGTCGCGCCGGAGATCGCCGCCGCGAACAAGATCATCGTTATGTGCGACGCCAAACTCGTTCAGTACCGCGCCATCGCAGACGCCGGAGGCGACCCCGCCACCGTCGCCGCCTGGATGGCCGAGGTCAACGCGCAACGCGCAGCCGCCCTCGCCCGACGCAACGAAGCCGCACGAGAACCATCTCCCCGCCGTCTCACCGAGAACGACATCCGACGCCTCGTCGGCAGCTTCGACGACATCCGCAACATCGTGCGCGATGCCAGGAGTGAGGACAAGAGCAACGTCTACCGCGAGCTACGGCTCGCCCTCACCTACGAACCCGGTGCAAACAAAATCAGCGTCGAGGCTAAGCCTGACGCTGATTACTGTGGGGTAACTGTACGTGTCCGAGGGGGATTCGGCCACGTGAACCCGGCACATCCGCTGGAAAACGGTGTGCATGCGTTGGAGAGTAGGCGGCGGCAGCCGGTCGGTCAACGACGGCACACGACGAGTCCTCTGGCTGTCCCCCGTCTGCACCCGGGCCCGGGCCGCTGCCGAGGTCGTGGATCTACGGAGCGTTTGGGCCGTGAACGGTGGGTTAACCGGAGGCGAGGGTTACCAGGCGCTTCCAACCGCTACCGATCTCCATCCCCGCAAACGTCACACCTCACCGCTCGCCGCTCACCGGCGTTGGCTCACGGTAGGGAACGAACACCGAGGTCTGCTTGTTCACTGCCCCTGAATATGGCACGCGCGGAACGAACAGCTAGGACTGCGGCTGTTCCCTCGCACTTGGCGGCGACTACCAGGGAACACGAGCCGAGAACAAGTGCCGGACTCCAAGCCTCGCGGCCGTTGTCAGCAGCAGACGCGCGAATGGCTCCTGATCGAGCACCGCAGGCAGTCGGAGGAACCGCCCGAGCCTGTGGGGTATGCGCTCCACAGCCGACCCCCGCCATGCTCGGCACAGACGGCTTCGCCCTCCGGCAGGGCCACCGCCGTCCGGCATCACCGGCATCTGGATTGGACGTCTTCGTCGGGATACTGGTTGCAATTCAGAGGTAGGTGCGACTGATCCTGCGGGGGTCCGCCGGCGTCCGAATCGCCGTATGCGCCGTAGCTTCAGTGGCGATCGAAGCACTCGGCTACGTCGCGTCACTGTCGGTCCGTTGGTCCTGCTGCCGGATTGCGGCGGAAGGTTTGGTCAGCGACACGGTGGGCGAAGAGCAGGGCCTGGCGATCGATCCCGATGTTGACTATGACTCGCCCGCCCGGCGCGACGGGACGGATCACGGGGCGGCCCCGGGGGATAAGTCTTTGACCGTCGCCGATCGACGGCCGTCAGTGAACAGGCTCGCCGGGCCCGGCGAGCTCTTCGGGCAAGGTCCGGAGAACTTCGAGGCTCTCGGTCGCCTGCTCCAGAGATCGGGAGCTTCTGCTGCTGGCTTGCTTGAGCTGCATCAAGCGCTTGTCCAGCTCCTTCTCGGCGCTATATTGAAGCCAGGCGTTGGCGCTTACAACAACGGTCGGAAGCGCACTAGCAACAGCGGCGATTGCAGTCGGAGGGACCGGAATCGGGAGTCCAGCAATACGGATCACCTTCGCTCCTGCCAGCTTGCGTGCGGCGTAAGCGATTGCTGGGGCTGCTGCTGCCGCAGAAGGTAGCCTGTTCCAGCGCTCGGGCTGAAACAGGGCGCGGATACTCTCATCAAGATGGTCAACCCGGCTGAGTACGTCTTCGATCTCAGTACGGACGCGGCCTGCAGAGCTGGTGGTCAATTTGGCTCGGGTCCTGGCCACGTCGACCTTGCCCTCATGGTAGTAGAGGGCGATCTGGGCGAGTTCCAATTGGGCAGTAGCCGCATAGAGCTGTCCCAGCAGGTCGAGGTACAGCATCACGTCCTCCACAGCTTCCTTGCTCAGGCTCTTCGCGGCCTGTCGTGGGGACCCGTGCTCCTTGGTGTGCTCCAATGTCGTGAGGGCCGTGTGGAGGTGCTCCATGCACGTCTTCACCGCTTTGCGCAGTTCGTTTTGGAGGGTCGGGATAGCGCCCGGCTCGACTCCGTCCCTGCCGTGATGCCGAAGTATCACGACCAGCTCTTCGACCTGCTCCACAGCACTGTTGACGTCACCGATCTGCCCGTCCCGCAGATGTTTGGAGATGTCGTCCACCCGCTGCCGGATGGCTTTGACCTCGATCCGTCAGACGGTTTTGCTCCCTGCTTGACCGTTTCGGCTTGACCGTTTTGTCCACTCGGGTGGGGTGCGGGATCGCCACATGTCGCTGTGGACGCGCCGAGGTCTCCGGACTCGGGAAACGGCCCTTTCTGCTGGTAGGTGCGGGGAACCAGGTCAGGTGGCCGGTGGTAGCAGGGTGAGGCGTCGCCAGCAGAGGGTGAACGCGTCGGCCCAGGGCCAGGTCCCGGGGATCGACAGCACGCGGCGGCGGGCGTGGGTGGCTAGTCTCGCGGGCAGGTGCAGCAGCCGGTAGCGCAGCGTGTCGGGTTCGGCGTGCGCGAGGTCCGGCTGGTCGTACAGGCCGAGGAGCCGTGTCCAGGCGGCGAGGTCGGCGGCGATGTTGCAGGTCAGGGTCCAGCCCTGGTTGACGGTCCAGTCCTTGGAGGGCAGGTTCCGCAGACCCGTCGCCTTGCCGTGGCGGACGTGATCTTCCACTCCGGCGTGGGCCCGGTGGAGGGCGTCGAGCCATTGCGGCTGGTGCGAGCCGGGCACGCCTGCGATCCGGGTGATGTTGGTGGCCACGATCTGGTAGCGCCAGCCGGTGCGTTTCTCCAGGGCGGTGAGGTTACGGGCGTGCCGGGCCGACGGCCTCGTGCGTCGTACGAGTAGCCGTAGCGTGCCGGTCCAGCCCGCGAGTCGGGGGTTGAGACCGGTCAGTTCCGCGACGTGCGCGGTGCCGGTGGCGGTGCCGTCCTGGTGCAGGCTGTCGGTCCAGGCGTCGGCGGGGACCTGTTCGATCGCGGTCTCGTCGGCGGCGGTGATCGTCCAGCCGACGGTGAAACGCACGCTGCGCCACACCCGGTTCATCCGCTCCAGATGCTCCAGTAACTCATGGGTGGCGCCGGCCCCGTCGACGCGGATCAGGAGTTTGCGCCGGTAGCCGGCCGGGAGCTGCGCGATGGCGTCACCCAGGACCCGGATGTGGTCGGCGACCGTGTTCGACCCGGCGTTACCGGGCCGCAGCAGCATCGCCAGGCACTCCGCCGTGTTCGCGCACCACGCGCCGAGCGGGTGGAAGCCGTAGCCCTTCTTGAAGGTGGCCGCTGCGCCCTGCTTGTCGCTGTGGGCGGTGATCAGCGTGGCGTCCATGTCGATGACCACCCAGCCGGTCAGCAGCTTCCCGGCCACGGTCAGCCACGGGAACCCCTGCGGGCGTCGGGCGAGCAGCGCCCACACGTGGGCGCGGACCTTCGCCCGGGCCTTGCCGACCCGTTTCAGTACCTTCTCGTTGAGACCGGCCAACGCGCGCCGGACGGTCGACTCCGACGGCCGGTCACCGAAGACCAGCCTCTGATGGGCGAGCAGGCCGATGTCGGACATGCTTGTGGCGCCGAGCGTGATCACCACGGCCAGACAGACCAGGACCGTGCCGCGATCCCACCAGCCGGGGCCCTTGCCGCGCGGCAGCACCTTGTTCAGAGCACTGGTCAGACCGGTCCGATCGGCGCATTTACGCAGCAGGACCGCACCCGCGTGACCGACCAGGCCCTTCCCGTCCGAGCCGACGACCAGCCGCTGATCCCACCCACTACTCTTACTCACCAGAAAGGTGCACCTTGCTCTGCTATGGACATGGCGTAGACACCCACATCCTCGCAGGCCAGGCGCACCTTTCGTTTACCGCCCTCGATCAGTCAAATCCCCCCTGACCAGGGGAGGTTGATGTGGCGGGCCATCTCGGCGGCCTGAGCTTGAGTCGCAATGCCGCCTAGGATGGCTGCCCCACCTGTCGCGGCGGCGACACCCGTGGCGGGACGGATCCGCATCAGCCGTGCGACCTGGCCTCGGCTGCGAAGAGTGGCCTGGATCCAGCCCCCTTCCTCGGTGATTAGCTCGGCGGTCGACCACATCGCGCGAGAGATGTGGTCGAGTTCGACCAGACCGCCGGTCAGGCGCCGAGACTCAATGAAGGACTTCATCGCAGGGTCCAGTGTTCGCAGGAGAGACGCTAGTTCCTCGGTAGTGAAGTCAGCGACCCTTCGTCCCCAGCGCGAGCGCGTAGTCCCGGAAGGGGCATCGATCATGATTGCTCGATCGTCAGTCAGGCTGAGGATGATCACTTCGGGTTCATCGCTCGGCGCCACTGAGCGCTCAGCGCCCTCGGCTGGACTCGACATGCGGTTGAGTGTAGGGCGATGCCCTGTCCCCGGACGTTCAAAGTGAGCAGCCGCCGGCAATGGCGACCCGATTCGAGCTGAGCTCACCTCGCGCTCGGCCGCCACTACGCAGTGAACACGAGCAGGGGAACAAGTGCCTGGAGTGTGCAACCACAGCAGCATCGGGCTCAATTGCCGTTGCCAGCGGACCGGGTCCGGCCGGAGACGTGCCAGGCGCGACACCCAGCGGTGGCTGCACCTGTGCGTCACGGCCTGGCCTCGGTCCTCGCCAAGGTGTCGGCGACGCGTTCGGTGAGGATCGGTACCCACCCGAGGTTTCACGGTCGCCGGGCCGAAATGGCGTGCCACACTTGGTCCGTCGGCCGCGTGGCTACTCCGGCCGGGGCCCGAGGCGGCCACCGCGTCGTACGCCTTGGTCACATGGGTTCGCAGGGTGGCGCGATGTCGTCCGCGTGCTCGGCGGCGTTGTCGAGACGGGCCAGCAGCGTGAGTGCCGCATGCCGGATCCGGAGTGACTCGGCGTATTCCGATTCGGCACAGCCGGTCCCGAGTGGCTCGGGGCAGCTCTTCCGAGATGTTTGGCGGCCAGACTGGCGATCCGCCAGGCTCCGCTGCGGCATTGGCTGTCAGCCGGCGACCCACGCGAGCGACGGTTGCTGGCCGGTATGGAGGTACTCGCGGGCGGCCTCGCGGGCGCGTTCCGGGCTGATGCGGGTGCGTTCGGGCGGCATTTCGGTCCAGTCTCCGTAGAAGTCGAACGCGATCGCTTCGGACACTGGGGGCAGGTCGGGGTCGGTGGCGTAGCGGTTGCCGCTGCCGTGGGGCTGGCTGCGGTCGAGCCAGTCGACGAAGGACCGTTCGGGGTGCCCTATCCCGATCATGATGGCGCCATGCCGGCCGGGTTGATGGATCTGCACCGCGTAGGGCAGGTTCTCGGCCGCGGCCTGGGCGTTGACACGATCGAGGACGAGATCCAGTTCCTGGGCCGTTGACACCGGGACCTCGTTGCCGCGGTCTGGCTCCTCTGCAGACGGGCCGTCCCAGGACACGATGTAACTCATGATGCGATGCCCTCTCCGGTGCCGGTGTAGACCTTCAGGAGCCTGGTGGCGGCCCCGTCGGACACGTATATCGCCAGGCGGCTGCCCCTGGGCAACATACCGGGTAGTACTTCGTCGCAGCCGACGTACTCGCCTTTGCTGACGCAGGTGGGCTTGTTGACCACCAGTACCGCCTCGCGGGGCGCGCCGGGTCTGCGCAGCAGTGCTGCGGCGTGTGCCTCCACATGCTCCCGGGTGACTTGCGCCAGCGGGTGCCAGTCCGGCCGGAGCCCGTCGCGTGCTCCGGGCGCCCCGCCGCTGCGCAGATACCCTTCCGACTGCGTCAGCGGTGGGCCGGTGAGTGGGGTGCCGCTGGTGTCGAAGAGCAGCCCGTGGGTCGGGCCCTTCCCGCCGGGCCGGCGGGGCAACCGGCCGACAGCGTCCTCAACCCAGCCCTGTCCCTGCGTTGGGGGCACGCCACCTGCTGACCGTTGCGCCGAAGTGCCGGTCTGCCCAACGTTGTCGGCGGACTGGCTGGATGATGCGGGAATGTCGATCCCGATCGCGTGGGCGTACGCCCTGACCGCTTCCGCGCTTTGGGCGGCGAGGTGGTCGGCTTCTCGGAGCCGTTCGATCGCCGCCGCGAAACCGGCCAGTGCCCGTCCGACGAGTGGGTGGCCGCTTCCCCGCAGCGTCACACCGAGGCGACTGCGGCTGTCCTGGAGATCGCGCACGACACCGGCGGTACGCCCGCGTTCACGACTGATGCTGTCGAGGATCGCCCGTAGTGCCGCGCCCACTTCGGCTACGCTCACCGATCTCACTCCTTGCTGCGGAGAGAGTGCAGCGTATCGATCGATTGGCTCTCGGGATACGGCCGGTCAGAACATCACCGCCAGACCGAAGAAGCGGCCCTCGTCCTTCAGCGGCCCGAGACGCTGCCGGTCGCTGTCGCGCACGGTTCGGATGAGGTCGCCCAGCCGGGTGCCTTGTATCCACGCGCACTGCGGACCGGTCAGCTCGGCCGGTCGAGCCAGCAATGTCTGCCAGAATTCGTCGTCGAGCGGCGGGGTATCTCCCATCCGCTCGGGCGAGTAGAGGACCTCGGCCGCGCGGTTGTCGGCTATCGCAGCGCGCAGCAGGTCCACGGCCCGGGACCACCAGGGGTTGGGGAACCAGGCAGAGGCGTAGATGATCCCCGACAGGCCCGTATACCAGAGGGCACGACGGGCGCCGATGAGATCAGTGACCTTGACGTGTGTCGTGACCTTGCGCATCACGTCGTCGGCGTACTCGTCCCACGTCTCGCCGAGAACCTCGCTGGCGGTCACCGTCGAGCCGCCCACGGTCAGTTCACGGTCCGGGTCCTGCATAAGCTCGACCAACGCCGCGATGTGGTCGGGCACCGAGCGTCGGTCGTAGACGATTTCGGTACCCGGCTGGGTGATCGAGTTGGGTAGGATGTCGTCGAGCATGTCGCGGACATCCAGGGCGGTGCTGATGTTCAGCCGCATCATGATGTCGTCGGGGATCCCGAAGCCCTGCTCGCGGCCGTCGAGGAACACGTCGATTCGAGCGGACTCGTCGGGGTCGACGTCGGCCAGCACCTTCCAGTTGGCGTCCAGCAGCTCGTAGTGTTCGCGCCGGGCGCGGCGCTCTTCAGCCTGCACCTCAGGATCGTCCGGATCTTTGCCCAGCTGTTCGAGGCGCTGGTGGCGTTCGACTCCGGCGTGGACATCCTCAAGTGCGGTGTTGCGCCAGCAGAGCACGGTCAGGCCAACCGCCGCAGCGTCCAACAGTTGGTCGCGGTCGCGCAGGTCGAGGCCGTAGTCCCCGGCCCACTCCAGCCACCTGTCGTCGCTGAGCCATCCATCCGGCGGGGCGATCTTCGGCCGGCGCGTGTGCTGCGTGGCACCTCGACGTCGTGCCGCTTGCTGCTTTCGACTAGCCATCGCGCCTTCCGTTGTCAGATCACCCGCAACCACCGGTCGGTCATCGCATCGATGGTATGCACATGTTCGGGGTGCAAGAGCAGAGCCTCGGCCTGAAGGCCCGCTTCCTGTGACAGGGAACGGAGTTGTCGGTGGCCCCGCCTACGCTGAGTCGAGTCGGGTTCGGCTTCAGAGTAAGGATCAACGCATGGCGTGGGACTGTGCCGCTCAGCGGCCTCGGCTCGGCGGATTCGACCCTGGTGCGGCGCGGCCATTTGACCGGATTACGGAGCTGTGACCGGATGCCGAAGCGCAGCGTTCAACAGCGCGCGGGGTTCCGGGGTGAGGCGTTCGTGGACAAGGCCGTCTCCGATGCTGGCCACGTATGGAACGACACCCGGCGTGACTTCGCCATTGACGGACAGATCGAGTTCGTGGATACCGATCGGGAGGTCACCGGGGTCGCTGTCCTAGCCCAGGTGAAAGCCACCGAAGTCGGGTTCTCCGGCGACTCGGCGACCGGGTTCGCCTTCCGCTGCGAGGCCGACCACATCGCCTACTGGACGCGGCTGGGCCGGCCAGTCGTGCTGATCTGCGTCGACCTGCGCGTCGACCAGGCGTGGTGGAAGCGCGTCGACACCTGGTTCGCCGATCCGGAACGTCGGGCGCGGCGTGTTGTGCGGTTTGACAAAATAGCCGACCGCTTCGACCCCGACTCGTTCAGCAAGCTTTCGGCTCTCGGCGTGCCGATCGGAGAACCGCTGCCGCGGTTGGAGGGCAGCGAGCGCCTCGTGTCCAACCTGCTTGTGATCGACCGCTTCGCGTCGAAGATCTACGAGGCGTCAACGCCATGCCGCGACCGCGGCGATGCCTGGGAGCGGATGCGCGCCAACGGCAACCAGTTCGAGGGCGGCTTCTTGCTGTCCGGCGGGAAAATCTACTCGATGTGCCCGCTCGACCACGGCCCGCTCGCCGTGCTGTGCGACGGTCCAGTGAGCGCCATCCCGACCGAGGCATGGTCGGGCACCGACGACCCCGCCCTGCAGCGCCGCTTCGTGTCCCTGCTCAACTTCACGCTGCGCTCGGCCTACCATCCCGACCTGGTTTGGCACCCCAGGAAGAGCGTCGTCTACATGCAGGCCCCACCGGACCGCTCCAACCGAAAGATCAAGGGGCGCTACCGGGGAGCGAAGGGGCGTAGCTTCTTCACCCCATACCGTGGCAAGGACGACGACACCAAGACCATGTTCTGCCGCCATTACGCCGCCGGGCTGTACTTCCGACGCTGGGGCGGGACGTGGTATCTGGAGATCAACCCCACCTACCACTTCACGATCGACGGGCGGCGCGAGTCGCTGTTCGACGCCGAGTACGTCAAGAAGATCAAGCGCCTGGAGCACAACAACGCGGTCTACCAACTGGTGCGTGCCTGGGCCGACTACCTGCAAGGCGAGGACACCCTGTTTAGAACCCGGGACGAGCGCATCCGCTTCGGCAGGCTGCTGGAGCTGGACTGCGACGCGGCAATCGACGAGACCGTCTGGATCCCGCAGGAACCGGCCCCTACATCCGGCACGGCCGGCCTCGCCCAAGGGCTATGGGAGCTGCCGTCATGAGAGCCCACGTGCTGCACGAGCCGCAACTGGAGTTCCGCGCCGGCAACCGGCATATCGACCCTCGCTACGGCATCAGCGCCTACGGACCCGCCGACGCCGAGTCTCCCTCCGCGCCGCGCCAGATCCCGATCGCCTTCATCGGCCCCTCCCACGCGGTCGACGGCATCCGTCGCTGGCTGCAGCGCTGCCGAGAACAGATCGAGGCCAAGAACGCCAAACCAGGACAAGAGAACCTGCACCAGCCCTTTCCTGGATTCAGCCCCGACAGCGAGTTCGGGTCCGAACTCGTCTTCGACGACGCACTGGTCCGGGAGATCCCCGAGCGGCAGCTACGCCGCCTGGCGCGTGCCGACACCGCCTCCGCCACCGCCGAAGCGGTGCAGACCTACGCAGACGCCGCCCGGTCGCTGGCTGAGACCGGACGCTGCCGGGTCATCGTCTGCGCCCGCCCAGAGGAGCTGCTGGACCGCGAGTCCCGCCCGCCGGCAGCCGAGGACGATGGCGCCGACCACGACCGTGATCCCGACGAGCGCGAGAGCAGCGGCGACTTCCACGACCTACTCAAAGCCGCCGCCCTCTCACTGCCGGCACCGCTGCAGCTAATGCGCAAGGAAACCTGGACCGGGCAGCCGACCAAAAACAGCGGACAGGCGGCCCGGCCGTTGCAGGACGAGGCCACGAGGGCGTGGAACCTGCACACCGCCTTGTACTACAAGGCCGGTGGGACGCCCTGGCGGATGCAGCGACACACCTCGGACCTGGCGACCTGCTACGTCGGTATCAGCTTCTATCGAACCACCAGCGGCCAGGAGCTGCACACCGCCGTTGCGCAGGTGTTCAACGAGCGCGGTGACGGCGTCGTCGTGCGTGGCGGCACCGCGCAAATCTCCAAGACCGACCGCCAGCCCCACTTGGCGCAGGCCGACGCCCGGCGCCTGTTGGTCGACGCCTTGGCCGAGTACCGCGGAACTCATGGCCACCAGCCCGCGCGTATTGTGATCCACAAGTCCTCCAGCTTTACCGATACGGAGGTGGAGGGCTTCCACGCCGCCGCCGACGAGCGCGACATCGACCATCTGGAGATGCTGTGGATCCAGCGGAGAGGCGCCCCACACCTGTTCCGCACCGGACAGCTCCCGCCGCTGCGCGGTACCTCGGTCCAGTTGGACCAGCGCTCGCTGCTGCTGTACACCCGCGGATCGGTGCCGTACTTCCGCACCTACCCCGGCATGTATGTACCGCAACCACTGCTCATCCGGCCCGAGTCGGCTAACACCGACCTGCTGGCCGCCGGCACCGACGTACTCGCGTTATCAAAGATGAACTGGAACAACGCCCAGCTCGACGAACGCGACCCGCTCACGCTGCGGACCGCGTACCGGGTGGGTGCCATCCTCAAGCACGTACCTGATGGCGCTCGCATCGCCACCCGCTACGCCTACTACATGTAGATCAGGCGTCGCTGTCCGGAGTCAGTGTCAGCCGCGGGCCCCTCTCTCGGGGCGCTTTCGCGCTCAACGCTGACGGGTCCTGCGTCGTGACGGTGCCCTCGGGGCACGTTTTGCAGGACTGCGCGGCGGCTCTTCCAGCCCTGCTTCGGTCTGGGGTCGACAGCTCGTAGCGATGGGCGGTAAGACAATCGCGGGGCCGTCCGCTGGCGGTCTTTCCTTCGATGCCCTCGCCGGAGGCTCCAATCTCTGCGGACCGCTACATCACAGAGGTCACCCGACGCCGCCTGCTCGACGGCTTGGGTTGGCTGCGCGACACCGTGCCGAATGGCATTCGGGAGTTCCTGACGCCGGCGCACACCTTCTGGAGCGGCGCCCTGCCCGAGACCGACTTCCTCGCCCGGCTCTACGACCTCGATCAGCTGCCCAGCCACGACTCCCGGTACACCACAGCGTTTCAGGACATCGTCCAGCACCGCGTCATGAACGAGGATTGGGAGGACGACTGGATATTCAGCGACCCGCGGTTCGGCCTGGCCGACAACGACGAGGCGCTGCTGCGGCTCCTCGCCGAAATGCTGCACCCAGCCGTGCGCACCGACCCGGCCGAGGTCGATCGGCTGCGCGAATTCCTCAACGACGTGCTGGTTCATGATGGCTATGAGCTGGTCCAAGTCGATGACATCAGCGGCGCCCCACTTTTCGCCCCACGCCGCATCGGTGGCGGCGTCCGCGGCACCATGAAGAACCTGATCTTCGCCGCGATAGGGCCCAAGCCCGACATCATGCTGGTCGATGCGATCAACAACGATCTACGCATCACCGGTAACGTGCAGGGTTGCCTTATGTACGACCGGCCGCTGGCCGCGCACGGGCTGACCTGGGCCGAGCTGACCGCTTGGTGGGCCGACCGGGAAGGCATGACCGGGGCGGATGCGCGGGAAGTCTCCTCAAGCCTTTACCGGCGGCTGGACCGCTCACTGGGCGACAACGACGCCGAACGGCGGGTCCTGCGCACCTACGCCGACCGATACCTGCGGCTGGGCCCGGACATTCCGGCGTTGGTCCCGCAGGTCTACCTGCACTACGACCCGCACGTACGCAGCCACTACCGGCCCGGCGCAGCGCCGTTGCCGCGCCAGCGGATGGACTTCCTGATGCTCCTGCCACACTGGGCCCGCGTGGTGATCGAGTGCGATGGCCGTCAGCACTACGCCGACGACAACGGCCGCGCCAGCCCACGGAGGTACGCCGAGATGGTGGCCGAAGACCGCGAGCTGCGGCTGACTGGCTACGAGGTATACCGTTTCGGTGGCGCCGAGCTCATCGATGGCCCGGACACAGCACGTCGGCTCAACACTTTCTTCGACCGGCTCGCCGACCGGCACCCTGCCTGATCGCCGCTCAGGCATCACCTTGCGGAAACCGAAGCAGCGGACCCCGGCAACACCGGCGAGCATCGCCTTCCTGCCGTCAGGGCTGTCGTGCTGCTGCGGTTCGCACCGCCCCGGACATTGGCGGTTTGCCATGATGGACCGCATGCCGCCGAAGACCCTTCACCCACCATGGCCGCCGGCCATCATCGAGAGCATCGCCGACGTTCTGGCCAGCACAGACTGGCCGGGCTTGACCAGAAGCGAGATCACCAAACTGCTGGCGATGCTGCGCATCGCCGATGTCGAGGCGCCCAACAAGCGGACCCGGCTGTGGGGGCGCTGCACAACCAACAGCTACGCGACGGTGCCAGCAACTGCGTTATCCGGTTCATCACCGAGGCGATGGCGCCAGGCCGCCACCTGCAAGACCAGCCGCGATTCGACGCGCTGCGCGACGCCCTCGCCGAACCGCTGTCGCTGGTCGGGCTGCGAGTGAACGACGAGGGTAAAATGGCTCGCGCGGCCGGCACCGCCACCACCCTCGACGAGGTCGCGCGCTTGGCCGGACGGCTGCGAACCGAGTTGCACCGCCGCGGCGTGCACGAGCAAGTGGTGCGCTACTGCGAGGAGGAGCTGGTGCGCCGCTCGCTGTTCCACGCAGTGTTCGAGGCGACCAAGGGCGTCAGCGACAGGCTGCGGCAAATGACCGGGCTCACCGCCGACGGCGCCGAGCTGATCGACCAGTGCTTCGGGGCCCGGACGGGAACACCTCTGGTGCGGATCAACGCCTACAGCACCGATTCCGAGACTAGCGAACATCGTGGCTTCGTCAACCTGCTCAAGGGCACCTTCGGCATGTTTCGCAACCCGCCGGCGCACACACCTCGGGCCACTGCTGGCTGGGCACTGACCGAGCCAGACGCGCTGGATCTGTTCTCGCTGCTGTCGCTGGTCCACCGGCGCCTCGACGGCGCCCAGATCACGCCCCGGCCCTGACAGCTTCCCTCTCTTAACGGGGTCAGCCGGACAGGTACGCCTGTGCCGCATCCCCGCACCCCTGGCAGCCCGCGAGATTACCAGTAGGCGCCGTGCCTGAAGTTGGAACAGGGTCCCTGCCGTGACATGGAATTCACTAGATCCTAGTGTCGGACGCGCCCACAATCACTCCATGGATCCTTGGGCGGAGGCCGTGAACGACTATGAAGTCACCGTCGAACCTGGAGCTGCCGGTGAGGCGGATCTTCTCGACAGCGACAACGACTGGTGGCTTGTGGCCTGCATGGATTGGCCGCGCGACCGGTGGATCGGCTACGTCCAGGGCTACTGGAAGGCAGCGACGGTCATCGTCGAACGCGTCGCGAGCACGGGGCGTGACCAGGACTACCTCGTCTACCCATTTCTGATGTGCTGGCGACACTACGTCGAACTGCAGCTTAAAACCTTGATCCTGTTAGCGGCCACATACCTACACAAGCCGTGCGACTTGCCCAAAACCCACAAGATTGACCATCTTTGGCGAGTAGCGCGCCCGCTGATCGAGCATTCATATCCGGGCGAGCCGACGACGGACTTGGACAACATCGAGCGTATCCTTCTGCAGTTGCACAGTTTCGACCCGACATCGGAGCACTTCCGCTATCCGATCTTGAAAAATGGCTCCGCGACGTTGACCTCGCTCGGTCGGGTTCACATGCGCCGATTTCACCTGGCGATGGAAAGTGTCGCCGGCCTACTCGATGGAGCGGAGACCGGGATCCGTGTGTTGATCGACCAGCGCAACGAGTACGAGGCGGCCATGTACGACCTGTACGGCAGCCCGGATGGGTCTCACTAAGGGCCTGACCGGAAGCCTTGTCGCCTGCTTGGCCATCTGACACGTACACGCGCTGGGCCTCCCAGGACCCCCAGCCCTGACCAGGGGTGCTCGAATGATTAGCGCCAGTTTTGTGGTGCTATGTCGTGCTTGAAGCCGCAGCGTTGGGATCGCTACTGCTACGTCCTGTCGGTCTGGCCGAGACCTGCCAGCTCACTCCTTGCGCATCACTCGCTATCTTTGGCGACTGGTGTGGGCGCTGTTTGATCCAATGGGCCTCTCGGCATCGGTCGGATGGAAGGTGAGCGTTGGACGCATTCGAGGTGCATCGGCGGCTGATCGATGACTACCGCACCTTCACCGAGGGGTTCGTTGACGTTCACGACGATCGGATCCGGGCTCGGGTAGAGGCGGAGAGCGCTCGGGGGGCGCAGTGGCCGGCGCCGTGGTCGTCGTTGAACCCGTCGTTCGAGCCCGGCGGGCGGGTTGATGATCTGGTTCGTGAGGGCCTGTTGCAGCAGGAGTGCGCGCGGATCTTTCGGGTGAAGAAGGCTCCGGATGATGCCGGCACGACGCCGATCACGCTGCACCGGCACCAGAGCGACGCGGTGCGGGTTGCCCGTACCGGAGCGTCGTACGTGCTGACCACGGGAACGGGCTCCGGTAAGTCGCTGGCGTACATGGTGCCGATCGTCGACCGGGTGCTGCGGGAGGGATCCGGACAGGGCGTCCGGGCGATCGTCGTGTACCCGATGAACGCGTTGGCGAACAGCCAGCAGGAGGAGATGCGGAAGTTCCTGGAGTTCGGCTACAGCGGTCAGCCTCCGGTGACGTTCGCCCGGTACACGGGTCAGGAGAGCGAGGAGGAGCGGCGGGCGATCCTGAAGCGTCCGCCGGACATCCTGCTGACGAACTACGTGATGCTGGAGTTGGTGTTGACCCGCCCGGATGAGCGGCGTCCGTTGGTGGAGGCGGCGCAAGGGCTGCGGTTCCTGGTGCTGGACGAGCTGCACACCTACCGGGGCAGGCAGGGCGCGGATGTGGCGATGCTGGTGCGTCGGGTCCGGGACGCGTGCGGCGCCGGGGAGACGTTGCAGTGTGTGGGGACGTCGGCGACGATGGCCAACGCGGGCACCGTGGCGCAGCAGCAGGTCGAGGTTGCCGATGTCGCGACGCGGATTTTCGGCGTGGACGTGATGCCGGAGCACGTCATCACCGAGACCCTGGTGCGCGCGACGACTGCTCGGGACGTAAAGCCGGCACGGTTGGCGGCGGTTGTCGCCGCGCGTGGTGATGCGGAGGCGGACGACCCGGCGCTGCGTGCGGGCTACGCCCAGCTCAGCGCGGATCCGCTGGCGTCGTGGATCGAGGACACGTTTGGGGTCGTGGCGGAGCCTGATAGCGGCCGGCTGGTACGGCAGCAGCCGACGAAGGTCAATGACGCGGCGGTGACGCTGGCCGCGGTGACGGGGCGCTCGGCGGACGAGTGTGCGACGGCGATCCGGGCGACGCTGTTGGCGGGTTCCCGTGCCCGTGACGAGGCGACCGGGCGTCCGTTGTTCGCGTTTCGGCTGCATCAGTTCTTGTCCAAGGGCGGCACGGTCTACAGCACCTTGGAGCCCGTGGCTTCTCGGGCAATCGAGACGACCTTCCAGCTCGTGCTGCCTGGTCAGCCGGAGCGGCGACTGTACCCGCTGGCGTTCTGCCGGGAGTGCGGCCAGGAGTATCTGATCGCCCGTCGGGAAAATCACGCGCAGACGGCGGTGTTCCGGGCGCGTCACGGGCTGCGGATCACCGACAGCGATGACGGTTACCTGTTCGTCTCGGCGGACCGGGAGTGGCCGGCTGACCCGGTTGCCGAGGGCCGCCTGCCAGGCTCATGGTTGTCGGCCGACAGCGCCGGTCACCAGGTGGTGCCGGCCAGACGTCGCGATGTCCCGATCCGCTATCGCGCAGCGCCGGACGGCACCGCCACCGTGATGGGCGCGGCGGGTGAGCCTGTCGACGGTGGCGTGGTCGCGGCGTGGATCCCGGGCACGTTCCGGTTCTGCCTGCGGTGCGGGGTGTCCTACGAGCAGGTCCGCAGCAACGAGTTCAGCAAGCTGGTCACGCTGGATCGCGAGGGCCGCAGCAGCGCCATGACGGTGGTGGCGTCCAGCATTGTGCGGGCGTTGCGGAGCCAGCCGGAGGTGGCGCTGGGCGCGGACGCCCGCAAGCTGTTGACGTTCGTCGACAACCGGCAGGATGCCAGCTTGCAGGCGGGGCACTTCAACGACTTCGCCTTGGTGGTGCAACTGCGCGCGGCGTTGTATCGGGCCACCCTGGACGCGCAGGCGGACGGCGCCGACGGGTTGGATCCCCTCGACATCGGCCAGGCCGTGAGCCGCCGGCTCGGTTTGCAGCTCCGCGACTTCGCGCAGGCGCCGAAGGCGCTAGATCTGCGGGCGGCGGAGCGTGCACTGCGGGGTGTGGTCGAGTTCCGAGTGCTGCGGGACCTGCAACGCGGCTGGCGAGTCACGCTGCCCAACCTCGAACAGTCCGGGCTGATGGTGGTCGACTACCCCTTCTGGTGACGCTGTCCCAGCGCGATGAGGAGTGGAGCGGTACTCACAAGCTGCTGGTCGATGCAGAGCCGGGCCAGCGGTACGAGATCACTCGGGTGCTGTTGGACGAGATGCGGCGTGTCCTGGCGGTCGACGCGGAGGCGCTGACGCCGGAGTTCGTGGACCGGCTACGCCGGCTGAGCCGGGAGCACCTGACCGGGCTGTGGACCGTTCCGGAGACCGAGCCCGATCCGGTGATCGGATTGGCCATCGCGGGTCGTGGTGGTCAGTACCGGCCTCGGCATGCGCTGTACCTGTCCGGGCTGGGCAGTTTCGGGCGGTGGCTGCGGCACCGGGACCGGTTTGGGCGGTCGTTGTCGCCCGCCGAGGCGGACGACGTCATCGGCGTCCTGGTGAAGCTGCTGGAAACGCACGGCGTGCTGGCGAAGATGGTGGAGAAGGGCGAGACGGGCTATCGGGTGAAGTCGTCAGCGATGCTGCTACGGGCTGGCGATGGTACGGCGGGCGCACCGGATCCGGTACGTCGCCGGTTCGAAGCCGATCAGCGCCCACGGGTGGTGCCGTTCTTCCGCGACCTGTACTTGGACGTCGGGTCGCAGCTGGCGGGGCTGCGGGCCGCCGAGCACACCGCTCAGGTGCGCGCGGAGGAGCGGGAGGAGCGCGAGCAGGCGTTCCGGGAGGGGACCCAGCTGCCGCTGCTGTTCTGCTCGCCCACCATGGAGTTGGGGGTGGACATCTCCTCGCTGAACGCGGTGGGGATGCGTAACGTGCCGCCGACCCCGGCGAATTACGCGCAACGCAGCGGACGTGCGGGCCGCTCCGGGCAGCCGGCGTTGGTCGTGACCTATTGCGCCAGCGGTAACAGCCACGACTCGTACTACTTCGAGCGGTCGCAGCTGATGGTGTCCGGCCAGGTGCAGGCGCCCCGGCTCGACCTGGCCAACGAGGACCTGGTTCGGTCGCACATCCACGCCGTGTGGCTGGCGGAGACGGGCGTCCGGTTGGAGCGCTCGATGGCCGACGTGTTGGCGTTGAACCTGCCCGGCCAGCCGGTGCAGCCAGAGCTGGCCGAGAAGTTGCGACGCCCGGAGGCAGCCGCGGCGGCGACCCGGGCGGCGCAGGCGCTGCTTCGGCCGCTGCACCCGGTGCTGGAAGGCTCGGCCTGGTGGACGCCGCAATGGGTGACCGGCGTGGTAGACACGGCCTTCGAGACCTTTGACCTCGCGTGTGGCCGCTGGCGCGACCTGTACACCACCGCCGACGCCGAGCGGCAGGCGGCGGCGGATCTGGCGGCCGACGCAACGGTCGGGCGGCAGAACCGGGAGGACGCCGACCAGCGGTACCGTGAGGCGCGGCAGCGCATCGAGTTGCTGCTCAACCAGTCCGACGACGCCGGGCAGAGCGATTTCTACACTTACCGATACCTGGCATCTGAGGGGTTCCTGCCGGGCTATTCGTTCCCTCGGCTGCCGCTGGCCGCGTACGTGCCGGGCAGTAGGGGGCGGGGTAACACCTGGTTGCAGCGGCCCCGGTTTCTGGCCATTTCCGAGTTCGGCCCGGGGGCGCTGATCTATCACGAGGGCGCCCGATACCAGGTGACCCGGATCAGTCTGCCGCGCAGCAGCGACGAGCAGGCCAGCGGCGAGGTGGTCCGCACCTCGGCGCGGGTGTGTGAGGCGTGCGGGTACCACCACCCTCGGCAGGTCGGTGTCGATGTCTGTGAGAACTGTGGGCAGCGGCTCGACACTACCTGGAAGAACCTGTTGCAGATGCAGACGGTGATCACCAGGCGGCGGGAGCGGATCAGCGCCGACGAGGAGGAGCGCAACCGGATCGGTTTCGAGTTGCGCACCACGTACCGGTTCGTGCCTCGCGGTGGGCGGCGGGGCCGGTTCGTCGCCGAGGTGCTCGCCGCCGACGGGGTGCCGCTGGTCGGGATCGCGTACGGCGACGCCGCCGAGATTCGCGTAACGAACCTTGGTCGCCGCACACGCAAAAATAAGGACACACACGGCTTCTGGCTTGACCTGGTGAAGGGCCGCTGGCTGTCGGAGAAAGAAGGCAAGGAAGGCGCCGCCACCGACGGGGCAGACGAGGATCTTGAGGCCAGGTTCGAGGACGTGAACCGCAAGGACCTGGTCACGCCATATGTGGAGGATCGCCGCAACATCCTGGTCCTGCGCTGGGCCGAGCCAGTCAGCGTCGAGGAGGCGACCACTTTGCAGTACGCCATCGAGCGGGGCATCGAGGCCGTGTTCCAGCTGGAGGACTCCGAACTTTCCAGCGAGTTGCTGCCAGACGGCGACGACCGCGGCCGGGTGCTGCTGGTGGAGGCTGCCGAGGGCGGGGCGGGTGTGCTGCGCCGCTTGCAGTCCGAGCCAGACGCACTGGCGAGGGTCGCCGCCGAGGCGCTACGGATTATCCACATCGATCCGGACACCGGCGAGGAGGATGACACCGCCTGCGTGCGCGGCTGTTACCGATGCCTGCTGTCATACGGCAACCAGCTCGTGCACGAGCTAATCGACCGCCGGCTGGTCGCGCCGACTCTTCAGGAACTAGCCACGGCAACCACCCACTCCGTGAACGACTCGGCACCGCAGGTTGGCCAGGACGAACACCTGGAAGCGTCCGGCCCCGCCGCCACGCTGCTGAGGCTGCTGCGCGAGCACGGCCACCGGCTGCCCAACCGGATCGGCGTTGAGGTCGAGGGCATCCGCATCGACCTGGTCTACGACAATGCCGATGTGCCCACGGTCGTCCTCGTCGACCACGACGGCGGCCACAAGCAGGACACCACACCACTGATCTTCGGAGGCTGGAACGTGATTCAGATCGGCGCCACCGAGGACATGCTTACCGCAGTGGCCGCACACCCCGGCGTCTTCGGCGAGGCGACCCGATGACCGCCGCGACACAGCAGACTCGACCGGTCTTCCCGGTGGGCTCCCTTGTCACCGCCCGAGGACGGGAATGGGTCGTCCTACCCGGCAGCGACACTGACTTCCTGGTACTGCGACCGCTGGCCGGCGGCGATGACGACGTGGCCGGGGTGTTCATCGACGAAGGTGTCACACACGCCACCTTCACCACGCCCAACCCGGACGACCTCGGCGACGACCGCAGCGCCCGCCTGCTACGCGACGCGCTCCGGATCGGGTTTCGGGCCAGCGGTGGCCCGTTCCGCAGCCTCGCTGGCCTGGCCGTTGACCCGCGTCCCTACCAGCTCGTGCCGCTGCTGCTTGCGTTGCGCCAGGAGACCACGCGGCTGTTGATCGCCGACGACGTTGGCATCGGCAAGACCGTCGAAGCCAGCCTGGTCGCCGCCGAACTGCTCGCACAGGGCAGCGCCCAGCGGCTGACCGTGCTGTGCCCGCCGAGCCTCGCCGAACAGTGGCAGACGGAGCTACAGGCGAAGTTCGGTATCCAAGCCGAACCGGTGCTCCCCGGCACCGTCCGCCGCCTGGAACGTGGCCTGGAGTACGGCCAGTCGATCTTCGAACGGTACCCGTTCACGATCGTGTCGACCGACTACATCAAGTCCGACATGCGCCGCGACGACTTCCTGCGGGCCGCACCAGAACTGGTCATCGTCGACGAGGCACACGCATGCGTCAGCGACGAGACCGGCGCCGGCGGCCGAGGCCGCACTCAGCGTCACCGCCTGCTCAAAGACCTCGCCGCCGACACCGAACGGCATCTGATCCTCGTCACCGCGACCCCACACAGCGGAAAAGAGGAAACGTTCCGCAACCTGATCGGTCTGCTCAACACGAGCCTGCGCGACACGAACCTCGCCACCGAAGCCGGCCGCCGACGATTGGCCACCCACCTGGTGCAACGCCGCCGCGCCGACATCCGCGACTACCTGGGCGCCGACACGAAGTTCCCGTCCGACCGGGCCACCGACGAACGGACCTACCAATTGTCCCCGGCCTACCGTGGCCTACTCGACGATGTCCTCGCCTACGTCCAGGGCCAGATCACCGACCGCAGCGGCAGCCGCGTCCAGCAACGCGTCCGGTGGTGGTCGGCGCTGTCGCTGCTACGCTCACTCGCCTCCTCGCCCGCCGCCGCCGCGGCGACCCTCGCCACCCGAGCCGCATCGGCGGGCGCCGCATCGGAGCAGGCCGCCGACACCGCCGGCGCCGCCGGAGTCCTCGACCTCGTTGACGACGACGCCTTGGACACCGCGGACGCGGTGCCAGGAGCGCTGTTCGAGGACGAGTGCGCGATGAGCGGCAGTGACGCGGCAAGGCTGCACGAGCTACGCCGACGCGCCCTGGCGATCGCTCAGGAACCGGACGCCAAACAGCGCACCGCACACGACACCAAACTGGCCCTGGTCACGACCACCGTGCAGCGGCTGCTGAAGGACGGCTTCCACCCGATCGTTTTCTGCCGCTTCATCCCGACCGCGCACTACCTCGCCGACCACCTCGCCGCCGCCTTTCCCAAGGCGGTCGTGGAAGTGGTCACCGGCGAACTACCGCCGGAAGACCGGGCCGCCCGGGTCCGCGACCTCGCCGAACGCGCCGGCACCACCAACAAGATCCTGGTCGCCACCGACTGCCTCTCCGAAGGCGTCAACCTTCAGCACGACTTCCAGGCGGTGGTCCACTACGACCTGGCCTGGAACCCGACCCGACACGAACAGCGCGAAGGCCGCGTCGACCGCTTCGGCCAGCCCCGCGACGTCGTCCGCGCGGTCACCCTCTACGGCTCCGACAACGTCATCGACCGCATCGTCATGGACGTCCTGATCCGCAAGCACGAAGCGATCCGACGCGACCTCGGCATCAGCGTCCCCGTGCCGGCCACCAGCGACCAAGTCCTCACCGCTCTCATGGACGGGGTCATGAAACGGGGCAGCACCTACGTGCAGGAAACCCTCGACATCGGGCTTCCCGAACAGGCTCAGCAACTGGAATTCGACTGGCAGAGCACCGCCGAAGCCGAACGACGCAGCCGCAGCCGCTACGCCCACCACACCATCCGCCCCGACGAGGTACGCCGCGAGGTCGAGGCCATGCGGACCGCGCTCGGCAGCCCCGACGACGTCGCCGGATTCGTCGCCACCGCCCTGCAGGAATGCGGCGGCATCCTGACCAACGAACCGTACGGCTTTACCGTCGAAGCCGTCGGCCTACCCGTCGGGCTCCGCGACGCCATCGGCAACCCGACCAAACCGCTCGCCTTCCACCGAGACCTTCCCGCGCCACGCGGCGCGGCGGTCCTGGCCCGCACCGACGCCACCTCAGCCTCGGTCGCCCGCTACGTCCTCGACGCCGCACTCGACCCAGCCCTGCCCACCGCCGCCCGGCCAGCCCGGCGATGCGGGGTCATCGTCACCAACGCCGTGACCACAGCGACCGTGCTGCTGCTGACCCGAGTCCGCGCCAACCTCACCCTCCCCGGGCGGTACGGCCCCCACGCCCAGGTCGCCGAAGAAGCCCGACCTCTCGCATTCACCGGCACCCCAGCGAACCCGCAGTGGCTGGAAACCGACGCCGTCGAAGCTCTCCTGGCAGCACAACCCGACCGCAACCTCAGCGCGGACATCGCCCGCAACATCATGAAGGGAGTCCTCGGCGCGATGCCCGCCATCACTAGCCACCTCGACCGCTTCGCCCACGAACTCGCCGAGTCACTACGCGACGCCCATGTCCGCGTCCGCACTGCCGCGCGAGGCGACCGCGCAGGCGCACTCGGCATCCGCGGGCTCACCGTCGAACCACAGCTACCTGTCGACGTACTCGGCGTCTACCTCTACCGACCGGCGGCCCAGGCATGAGCGGCCCTGGGCTCCAAGGCATCCACGCCGTCGGCGGCGTCGTACCACCCGGCCTGCTCGCCCGCATCCAAGCCGGCGAACTCAAGGACCCTGCCGGGCTCGCACCAGCCTCCTACCACCTCGTCGGCCGCGAAACCGTCCGCGACGCGGCCAGCCGAGCCTGGTCCTATCTGCGCGGCGCCTGGACCGCCTGGCGCGAGCACACCGCCACCCAACCACCCGGCACGCACGGGATCGCCGCAGCCCGGGAACGGTGGCTGCTGGTCCTGCTCCGCGAACTCGGCTACGGACAGGTCCCAGCACTACCCGCTGGCTACACCATCGACGAGCGGCACTACCCCGTCTCCCACGCCTGGCAACACGTACCGATCCATCTGCTCGGCCCTGGCGTCGACCTCAACCACCGCAACGCTGACGTCCCCGGCGCCGCCCGCGCCCCGCAGGCCATGCTGCAAGAGCTGCTCAACCGTAGCGACGCCCACCTGTGGGGCATCCTGTCCAACGGGCTACGCTTACGGCTTCTCCGCGACTCCACCGCCCTCGCCGGCTCCGCCTACCTCGAATTCGACCTCGAAACGATCTTCGACGGCGAGCTCTACCCCGAGTTCCTCCTCATGTGGCAGCTCTGCCACGTCTCCCGACTGGAACAGCGACCGACCGATGTCGACACGGCGGCGAGCCCCGCAGGCTGTTGGCTGGAGGTCTGGCGCGGCGAAGCCGCCGAAGCCGGAACCCGGATGCTCGACCGACTGCGTGACGGTGTCGCCGATGCCATCGCCGCGCTCGGCACCGGATTCATCCGGCACCCCGCGAACCGGCCCCTCGTCGAGGCGCTTCGCAGCGGCACCCTCAGCACCGCCCAGTACCACCGGGCGCTGCTGCGCCTGGTCTACCGACTGCTGTTCTGCTTCGTCGCCGAAGACCGCGACGCGCTGCTCCACCCGAACGCCACCGCCCAGGCACGGGACCGATACAGCCGCTACTTCTCCACCGCGAGGCTGCGCAAACTGTCCCGCAGCCGCGCCGGCAGCCCACACCCGGACCTCTGGCAAGCACAGACTCTCGTCCTACGCGCCCTCGGCGGCCACGGCCACCCCGGCCTCGGACTACCGCCGCTGGCCGGACTCTTCGACCCCGACCCACACCTACCGACCATCGACCGGCTCCCCGCAGATCCACTGCTCGGCTGCGAGCTGACCAACGAAGACCTGCTCACCGCCGTCCGCAAACTCGCCTGGGTAGCTCTGCCGGGGCAGCGCGTACAGCCCGTCGACTACCGCAACCTCGGCGCCGAAGAACTCGGCAGCGTTTACGAGTCGCTCCTCGAACTCGTACCCCGCGTCGACCTGACCGACCGCACCTTCCAGCTCGTCACCGTCTCCGGCAACGACCGCAAGACCAGCGGCTCCTACTACACCCCACCCAGCCTCGTATCAGCACTCCTCGACACCGCACTCGACCCGCTCCTCGACGAAGCCACCGCCGACGCATCCAGCCCAACCGATGCCGAAACCCGCCTGCTCGCCCTGACCGTCTGCGACCCCGCCTGCGGCTCGGGCCACTTCCTCGTCGCCGCCGCCCGCCGCATCGCCCGCCGCCTGGCGCAAGTCCGCTCCGGCGACGATGAACCCACCCCCGCGCAGATCCAACACGCCCTGCGCGACGTCGTCGGGCACTGCATCTACGGCGTTGACCTCAACGATCTCGCCGCCGAACTGGCCAAAGTGTCGCTCTGGCTGGAGGCCCTGGAACCGGGTAAACCACTGGGCTTCCTCGACGCCCGCATCCGCATTGGCAACTCCCTGCTCGGCGTGACCCCCGCACTGTTGCACGGCCCCGTGCCCGACGAGGCATTCAAAGACCTGGAAGGCGACGACAAGAAGACCGCCGCGGCAGTCCGCAAGCGCAACAAGGCCCAAGCTGTCGGCAAGGACGGATACGCGCAGGACCTCCTCTTCGTCGGCGGCCCAGCGATCTCCAACGCCGACCTCGCCGCACAGCGAACCGCACTGCTCGATCTGCCCGAAGACGTCGATTCGGTCCGCGCCCAAGCAGATCGGTGGGAAAAGCACGAACAGTCCCCCGAATACCGCGCACAGCGCCTTCACGCTGACACCTGGTGCGCCGCGTTCGTCTGGCCGATGCCCGAGCCAGGGACCGGTTCCGTACCGGAGCCACCCACCAACGCGATCATGCGCGCCATCGCCGACAACCCACTGAGCCAGGTGCACGCCCACCTGACCGAGTACGCTGCGCAAATCGCAGCGCAGTACAGATTCTTCCATTGGCACCTCGAATTCCCCGAGATCTTTCACGTCGATCACGCGACGGTCGACGCAACGCTGCGGGGCTGGAACGGCGGCTTCTCATGCGTCCTCGGAAACCCGCCCTGGGAACGGGTCAAGCTCCAGGAGAAGGAGTTCTTCGCCGTCCGCCACCCTGAAATCGCAAACGCCGCCACGGCCGCCGCCAGGAAGAAACTTATCGCAGGTCTCCAAAATTCTGAGAGTGCCGCCGATCGCGCACTGCACGAAGAATGGACGGCAGCTCTGCGTGTGTCTGACGGGACAAGCGCGTTAATTCGTAGATCGGCACGCTTCCCGCTGACCGCCACAGGCGATATCAACACCTACGCAATCTTCGCCGAAGCTGCGCTCTCCATCATGAGCCCGACCGGACGGCTTGGCATAATACTGCCGACCGGCATCGCTACCGATGCAACTACCCAGCGATTCTTCCGCGAATTGATCACAAGACACTCGCTGGTATCCCTCTACGACTTCGAGAATGAGGAAAAGATTTTCGCCGACGTCAATAATCGACCCAGGTTTTGCTTACTATGCTTGACCGGAAAGCAAGCGGGGCGGATCTCGCTGGCGTTTCGACTCCGGCAACCGAGTCAGATTAGCGACCATGCATACGAAATCACACCGGACGAGATTCTACTTCTCAACCCGAACACGGGCACCTGCCCTGCATGCTCATCCCGCCGTGATGCCGAAATCGCCATCGACATCTACCGCCGCATTCCGGTGCTGTGGCTGGAAGGGGAGGTAGACGGCAATCCGTGGGGATTGTCGTTCATGCGTATGCTCGATATGTCTACCGACTCGGGACACTTTGTTGCGGCAGCGAAAGCCGATTCAGATGGCTGGTCGCGTAAGGGCGGCTACTATCGGCGCGGCCATGAAAGTCTCCTGCCATTGTATGAAGCGAAGATGCTGCACCACTATGATCATCGATTCTCTACCTATGAGGGTGCAACGCAGGCGCAAATTAACAAAGGCACGTTACCGAGGCTGGACGACACCGCCCACGCGGATCCGTTGGCCCACACACTGCCGCAACACTGGGTGCCAGAATCTGTAGTTGAAGAGAGGCTGGCGAGCGACCCGAAGCGAGCGCGGCCGGGTTGGTCGCATGACTGGCTGCTCGGATGGCGTGACGTTGCACGTGTCACCGAAGAACGCACCTTCATTACGACGGTAATCCCTCGTGTGGCGGTAGGTCATAAATACCTCTTGGCGCTTCCACGCGAGGGTTCCATTGCATGCTTACATGCAAACCTTAGTACCTTTATCTTTGACTACGTTGCCCGCCAAAAGTTGTCGGGCGCAAGTATGAGTTACTTCATCACCAAGCAACTCCCTGCATTGCCCCCGAGCGCCTACCGACGTGGCGTGCCGTGGTGCGATAGCAACGGGAACCTTGAATCATGGATCAAGGTTCGCGTGTTGGAGTTGAGCTTCAATTCCTACGATATGCGAGGGTATGCGCGCGAACTAGACGATGAGGGTCAACCTTTTGTGTGGGCGAGTGGTCGGCGGGAACTTTTGCGGGCCGAGTTGGACGCGGCGTATTTCCACCTCTACGGGGTTGGTCGTAGCGATGTCGACTACGTCATGGACAGTTTCAACCTCGTTCGCAAGGATGACGAGAGAATCTACGGTGATTACCGCACCAAACGGATGATCCTGGAGATCTACGACGCCATGCAGCACGCGATCAACACGGGTAAGCCGTACACCACCATCGTGGATCCACCGCCCGGCCATGGTGCGCGTCACCCGGCACGAGATGAGGCACTTGCATGAGTGACAGCCAGGTGATCCTCCCGACGCGTAATGACGGGCTGGTCCGGCAGGTCGGTCGGGAACTCATTGAGCAGGGCTTTCAGCACGGTCGCTCACTGTTCACACCCGAGCGGTCGGTATGGAACCCGGACACAGCGGGCGAACTGCACCGTCGCTACAACGAGCAGCCGGACCTTGGCGTGGACCCATTCCTGGTCAAGCTGCGTCGTCAGCTTGGCTCTGCCTCTGATGATGCGATCCAGCTTGCGGCGGAGTTGTTGACGCTGCAAGGGCTTCCGCTGGTCAACCTGACGACCGCAACGCTCCATGCTCGTGTCACCGCAGTGTTGGGCTGGATGCGCGAGCCGGTCACCGTTCCCGACCATGTCCTCGCCGCCTTCACTCAGGGAACGTGGAACGGCGGGATCGGCGCGCACACGATGCTGTGGAAGTGGCTGGCCGACGCGGTCGAGCTTGTCTGCGGCTGGTGGTCGCTCCCGCAGGACCAGCGGGAGCGTGCGTTCGCCGATCCGTGGGCGTGGCAGGACGCCGTCTACCAGTACAAGCTCATGCCGTCGCTGCGTGAAGAGCTGCTGTACCTAAGATTCCCGTCGTACTTCCTGCCGATCCTTAACATGGCCCACAAGAAGGCGATCCGCGACGCGTTCGCCGATCCGACTACGCCGTCGACCGGTGACCTTAACCGGGATCTCTTTGCCACAACAGTCAGGATTCAAGGTCAGCTCGGGCAGCCAGTCGACTTCTACCAGCAGCCATTCGTGGCGCAGTGGCGTAAGCAGGCCGAGAGACCACCGGGCGAGCGTCGGGCCTGGCTCGTCCGACCCCGGCAAGGTGGACATGATCTGGTGGAGCGCTGGAGCGCGGAGTCGTTCGTCTCCCTTGCCGCCTCTCATCTGGGCGAGGTGTCGCCTGGCGCGTCCAGGGCTGAGGTCCGGGCCGCGGTCGAGGCGGGCTACCAGCATCTGGACTATGCCCAGCGGGTAAGCCTGGCCAACGAGTACCACGCGTTCCTGTCTCAGATGGACAGTGATGACGTCGTCGTGACCCTGGTCGACGACCAGCTGTATGTCGGTGTTCTCGACGGCGATCCGGAATACAGTCCGACCGATGGCGGCGCGCGCTTGCGCCGGGCCGCTGGATGGCTGGCGAGCGCCCCGATCGCGGTGGACGCGTTGCCGGCGCCGTTGCCGGCCGAGCTGGATCAGCAGGGCACGGTGGTTGACCTGACCGGCGCGTTGGACGTGTTGGCCGGGCTCGTCGAGGTTGATGCGGAGACCCTGGAGGCGCCAAGCCCGCCGGACCGGATGCAGCCGACCGTCCGCGTTGTCCCGAAGCTGCCGGCGGTGACGGATGCCCTGGCCACGCGGCTGTACATCGACCGGGCATGGTTGCATGACCTTCTGGGGTTGTGGCAGGAACGTTCACAAATCGTCCTCTACGGGCCGCCGGGCACCGGCAAGACCTACCTCGCGCGGGCGCTCGCCGCGCATGTGGCCGAGCGGGACGCGGTCCGTCTGGTGCAATTTCACCCCTCGTATGCCTACGAGGACTTTTTTGAGGGATTCCGCCCCATCGAAGGCGCCGACGGCGGACCGGTGAGCTTCGCCAAGACACCCGGTCCGCTGCGCGAGATCGCCGCCGAGGCCAGGAACAATCCGGAGAAGCCGTACGTCCTGATCGTCGACGAGATCAACCGGGCGAACCTGGCCAAGGTCTTCGGCGAGCTGTACTTCCTGCTGGAGTACCGCGAGGCGACCATTCGCCTGCAATACTCCCCGTCCGAGGCGTTCAACCTGCCGCCCAACGTGTTCATCATCGGCACGATGAACACAGCCGACCGTTCGATCGCGTTGGTGGACGCCGCGATCCGGCGCCGGTTCGCGTTCATCGAGCTGCATCCCGACGATCCGCCCGTGCGTGACGTGCTGGGCAACTGGTTGACGGCGAACGGCAAGGACGGCGATGAACGGGCCGTGCTGCTGGCGGCGCTCAACGAGTCGATCGGTGAGGAGGACCACGACTTCAAGATCGGCCCGTCGTACCTGATGAAACCGAACCTCGACAGCGAGGCCGCGCTCGACCGGGTGTGGCGGTACGACCTGATGCCGCTGCTGGAGGAGCACTACTACGGCCGGCTCACACGGACCCAGATCCGCAATCGGTTCGGGCTCGCGGCCATCCGCGCCCGGATTATCCCAGCGAATAGCGGCGCCTCACCGAGTACCGCCGACGAAGCGCCGCCGTCGGAATGAGCTGGCTGCCGGTCAACCTCGCCGAGCTCGACAAGACCGGCGTTCGTCGGCAGCTCGACGACGATACCGCGAGCGCGTTGAGCAGCACCGGGCTCGTCGAGGTGCGTCCCGAGGGCGGTGGTTGGTGGCACCTGCTACCGGCCGGGAAGGTCGGCGCGGTCCGGATCGGCGGACTCGACGTCCAGGTGCAGCCGAAGGTGGGGATCGCCCGACTGCTGTTCCTGCTCGGCTACGCCCTGGATCCGGGGTTCAGGCCGGAAGACGTCACCGCGATACCCGAACCGGACCTGTGGCCGGCGTTGGCCGAGTCGTTGATCCGGCAGGCCGGACGCGCGCTCGCTCCCGGAGTTCTACAGGGGTACGTGTCGGTCGATGAGTCACTGCCATTGGTTCGCGGCCGGATCCGGTTCGCCGACCAGTTCGCCCGCCGTCCCGGCATACCGCTGCCGATCGAGGTCCGCTTCGACGAGTACGCCGCGGATATCGCCGAGAACCAGATCCTTCGTACTGCCTTGCGGCGCATGATGGCGGTTCCTCGGTTGCCAGCCGGCGCGCGGGCTCGCCTCGCCCACCTTGACGGCCGGCTCGACGGCGTACGGGTGCTACCACATGGAGCGCCCCTGCCGGCCTGGCGCACGAGTCGGCTGAACGCCCGGTACGCCCCGGCGCTCAGGTTGGCCCAGCTGGTCCTCCGCTACCAGTCCGCAGAGCCTGGGCCTGGCGACGTTACCGTGGCCGCGTTCGTCGTGAACATGGCCAAGGTCTTCGAGGACTTCGTCACCACCGCTCTGCGCGTGGCGCTGGCCCCGTATCCTGGGCACACCGATGGCCAGTACCCGGCTCACCTCGACGTTGACCGGACCATCCCCATCCGGCCCGATGTGGTCCACGTCGTCAACGGCCAGCCGGTCGCGGTCTTCGACGCGAAGTACAAGCTTGAAGGCGCCAGCTCGGGTTTCCCGAACGCTGACGCGTACCAGATGCTCGCGTACTGCACGGCGCTGAAGCTGCGCCTCGGGTGGCTCATCTACGCTCAGGGCACGTCGGCGCCTGGCCGCCGCAGGATCCGCAACACCGAAATTGACGTCGTGCACTACCCGCTCGACTTGGCCGCGCCGCCGCGCCAAATTCTCGTAGAAATCGACGTCCTGGCGCACAAGGCCATGCAGAAGCACGCGGTGACGGAGGACCGTTGAGTGGGTCACGGCTCAGGCTCCGAACGCTCCGCCGTCCGGTCCTGCAGGCGGCAACGGTTCGGGGTGATGGCGAGCGGGTGTGGTTGGCCGGTCATGGCGGCCAGTGCGGTGGCGACGGCTTGTAGGTCGGCTTTGATGTAGGTGGTGGTGGCTGGGCCGGTGGAGTCGGTGTGTCCGGCGTAGGCGCGGGCGATGCCGTAGCCGTAGTGGCGTTCGACCCAGGTCAGGGTGGTGTGGCGTAGCCAGTGGGTGGAGATGGCCTGGGCGGCCACCCACGGCAGTTGTGCGCCGATGCGTTTCCATAGGTGGTCGTAGCGGCGGCTGGTGATTGGCCGACCGTTGCGGTAGCGCAACAGGCGGTCGGTGGGCAGGACCGCCCCACGGGCGCGGGCGTGTTCGTTGAGGTGGGTGGCCAGGTCGAGGGTTATGGGTTGCCAGCGCAGGGTGGCGCCCTTCTCGGTCAGTCGCACCAGCCCGCGGCTGGTGTCCAGGTCGGTCAGTCGTAGCCCGAGTGCGCCGCCACGGCGGCAGGCGGTCTCGGTGTGCAGACGCAGTACCAGAGAGTCGAGGATGAGGTCGTTGCCGCTGGTCCGAGCAGCGAGGTTGATCTCTTCGAGTTCGTCGGGGGTCAGGGCGCGGCGGGTGCTCGGTAGTCGGCGGGGCTTGAGCACCCGGTGGGCGGGGCTGGCGGTGGCGTCGATGAGTCTGTCGGCGATAGCCCGGTTGTAGATGGCGCGTGCGGCGGCGATGACGTGCTCGCCTGCGTGACGGCCGTTGCGGCTGTTGCGCCGTGACCGGGCGGTCGCGGCGATCTCTCGCTGCATGGCCTCGATGTCGCTGGCGGCGACAGCGTCCAACGGACGGTCGCCCCAGGCAGCGGCCATCCGCCGCCAGTAGGTGCCATACGTGCGGTGGGCGCCCGGCCCGGCTGCGGCGATGACCTGGGGCAGGTACTCGGCCAGTGTCGGCAGACCCGGACCAGGCTCGGCCTGCAGATCGGCGAGGGTGACGCCCAAATGTGCCAGCATCTGCCGGGCAGCAGCGACACGGGCGGGATCAGCAGACACGACGACCACCGATCGCCTGGGCGTGGAGGTCGGTCAGCAGCCGTGTGACGGTACTGGCCGGATGAATTACCAGCAGGTCGTGGACGACCAGAGCGGCGAGCAGCAGCGGCTGCCCCGGCAGGATCGCGCTCATTTGCCGGACGTTCGCTGGTAACGGCAGTTCTCCTCGGCTGCCCACCACGTGTTGTCCGGCTGGCGCTGACGCGACCACGAGCATTCCGCCTTGTGGGTGGATGTCGATGCGGTGGCCCGCCGGCCAGCACAACGCCCCCAGCAGGCCGCGCTCGGTCACTCGACCGGATCGGTCCGGACGCGCCATACCGATCAACACCTCGTTCGATGAGGCGGTCGCTGGCGGATGTGGTGCGGGCAGCGCCGGCATCGGCGCCGGACCGGGGCGCTGTCTGTCGGGAAGCGGGGCCGGAATGAGCACGCCGATGAGTCGCTCGCGGTCGCGGCGGCGGGTTGGTGTCATGACCGGCCCAACCGCGAAAGCGTCACTACGCGTCGACGGTGATGCGTAGCCCACCGACGCCCGCGATCATGGTTTACCGCAAGTATGCGGGGCAGACACCAACACGGAATCGAATCCGGTTCATGTCTGGTGAAGCTCCACCAGAACTGGTGTCCGAGGGGGGATCGGCCACACGCACCCTGCACACCTGCCGGAAACAGGTGTTCATGCATCGGACGATAGAGTCCCGACGCCCAACGGTCAATCAGAGGCCTCCTGTGCCTTCCGCTCCGCGTAGCGGCGCGGAAGGCACAGGGGTTCAGATCAGTGGCCAGCCGACCCGCGTACAACCGCGATAAGCTGTATGCACGCTCGAGGAACCGGACATCACCTACGCGATCGGGTCGACGCTCCCTGTTGCTGCATAGCACCTGGGACAATTCTTGTCCGACCGGACATTCGCGCACGTGGCGCACCAGGGGCAGATGAAGACACGGCTGCGGGTCATGCACCGCGCAACGAGCAGGTCGGTGCCATACCACTGGTCGATGCAGTCCCCGTCGGGAGTCTTTGGCGATTCACCGGCGGTATCGAGGACCGGGTAACTGCGCGTGCAGGTTCGACAGCGACGGCTTTCCCAAGCCGCGCCGCAGCTCGTACAGGAGACGTGGAAACAGTTTTCCGCACGCGGACGCAACGCCCGTTCGGGCTGCTCGGGACGGGCGTTGCAGCGCGGGCAACGGGTCAGTTCCACGGTCCGCTCGACGGCCTGTTCGATGCCGTCCCACAGGTTCTCCAATTCGCTCTCGTTACTGCCGAGGCGGCGGAACCGGGCGGTTCCCCGCTGGATCGCCATCAGGTGCATCCGGGCGCTGACCAATTCGTGCGGTCCGGGCACTCGGGTCACGGCGATGCCGTCGGCTGCGGCAGCCAGCCAAGGGATGTCCGACACGACGTCGCCGGCCGTCGTCGCGCCGCACGGCACCGCGTACGGGTAGCCGGCGAAGCGCGGTTGCTCCACCAGCCACCGGACCGCACGGGCGAGGCGGACGACGCTGTCGACCTCCAGCGGCGACACCGGTATCGGCCACAACATGGCACCCGAATGATCCGGCGCCGGAGTCGCCGGCGACTCGTACACGCGCAGCCGGACTTGAACCGGCAGTTCCTGCCGCTCCTCGCGACTGCCGGGGTAGAGGACCACGGTGGGCACGTTCGGCACCACCGTGGTCAACCGCTTCATTTCCGCCGCTACGGCGTCCCCGGTGCGGGAGGCGGTCAGGGCGTGTGGCAGCGCGACGACCCGCAGGACCGGGGCACCGTCGCGTTCGATGAGGAAGACGCCGCCGCGATCTACCCGTAGGCTCATCGCCGTCGCACGGAGCTGGTACCGCATCGGGCCGGTGGCCGCTGCAGGCTCAACGGGTGTCGCCCCCAACTCGTCGAACGCGCGGACGGCCAGTACCCAGGCGTAGCGCACGAAACCCTCGCACCAACGCCGGGTGTGTCGTGCCGCCTCGTCGGCGGACTCGCTGTCGGCGCGGGTGGCGACCAGCCGCCGCCACAGCTCCGCGACATGCCGGTAACGTTCCTCCCCGCCGAACAGGTTGGTGGAACGCAGTGTGGTGCCGAGCGCCGCCTGCCGGTTGACGCCGCGCCAGAGCGGCGAACCGCGCAGCGCCGAGACGGCGCTGCTGAGCTGCTCCAGCTCCGCCAGTCGCAGTTGGGCTTGGGTCTTCCAGTCGGCCTGGTCGACCAGTGCGGCGACGAGTTCCCACAGGCGGAGGCTGGTCTGCCAGGGGCGTCCGCTGATGTCGTCGATGTACCGCTGGATGTCGCTGAACATGCTGCCGAGGCTGCGGATCTGCGCCATCCGGAGGCTGAGGTACCGGGAGAGCTCGGCCACGAGGCGGGCGACGACCCGGTTCTCGTACAGGTCGAGGTCGGTTTCCCGCTCGGGACTGAGCACCCGGTCCGGGCGTACCCCGTCGGGCCGTCGTGCCGCCCAGTCCTCACTGTGTGCGGCGAGCCGGACGATCGAGCGCGTGGTGACGGTCCGCGCCCGGGCCACGGGCACCTGGCGGTCGACCGACCGGAGGCGGGCGGCCGGTCGGAAGCAGACCGCTCGCAGGTACGGCAGGTGTTCGTCGATGGCCGCCTCCAGGGACTGCCGGCTCAGCATCCGCTGGGCGTACCCGCCGTCCACCATCGGCGAGACCTCGACCAGTGCGCCGAGCGGCGCGCCGCGTCGGACGAGCCCGGCGACCCGCTCCCCGATGGCGAGCACCGCTGCCACGGTGACCGCGTCGGGCAGGGCCGCCCGCCGGCGTGACGGCGAACCGATGTCGAAGTCGACCGAGAAGACATCGGGCGCCGCGGTGTGCCGGGCGTATCGCCCGAGGGTGGCGGCCGAGGGTGGTGGGTACGCCGGGACGACCCGCCCGGTCAGCCGGTCGTAGAGCCGCTCGGTCCGCGTCATCACTGGTGGCCGAGGTCGCGGACGAGGTCGTCCAGAGCCGCCAGGGACCGGCGCGGCTGGCCGTCGCACGCCTCGTCCCCCAGCTTCGGCCAGCTCGCGGCGAGCTCGTCGCGCAGCCGTCGGAGTTGGTCGACCCGGATTTCGTACCGCCCCCGGAGCTTCCGCAGGATCTTCGTGGCGACCAGGTGGTCCGTCGCCTCGGTGAGCGACCCACCCGCAGCCAGGACCACCGGCACGTACCGGTCGACGTGCTGGTAGAGCCGGCTGCCCCAGGAGACGCGGAAGTCGGTCGCCATCCGCTCGGCCAGCACGGTGGCGAGGAACTGCCGCGTCCGGTCGGCGGAGGCTCGACGGGCGGCCGCCGCCGCGTCGAACGCCTGCGACAGCGCCGCGAAACTCAACCGCGGCAACGGGTCCTGCGGATCGACGTCGAACGGCTGCGGGCTCGCCGGCAGCTCGACGACGTGGGCCCGGTCGTACGTCTTGTCCGCGAACGAGACGGTGGTCTCGTCGTGGTTGGCCGTCCCGACGAAGAACACCGAGCGCGGCACCGGCAGCAGCCGGCCCTCCCGCAACAGGCGGGGAGCCGGGGTCACCCCTGCGCTCATCAGCACCAGGTCCGGCGTGGCGTCCCGGCTGGCCCTGCGTTCCAGCGCGGAGAGCACGTCGTTGAAGTACTGCTCCGGGTGGGACAGGTTCATCTCGTCGAGCACGATGAAGAACGGCTGGGCGGCGAACTGCGGGCACTGCGCCTGGTAGAGCGCCTTGGTGAACTCCGACTCGTAGAAGCGGCGCTCAAACGCGTTGTAGTAGCCCATCAGGTCCTGCGGGGTACGCCAGTCGGCGCCCACCGAGACGACCGCCGAGGTGGCCCCGATCGCCTCGGCGAAACGCTGCGGCAGCTGCGTCTTGCCGATGCCGCTGATGCCCTGCAACAGGTGGAGCTGCGAGGTGGCGAGGCCGCCGAGGAACGACCGCAGGTCGGCCTCCTCGTAGAAGAGGCCGTGCTGCTGGCGGATCAACGCCCGCACCCGCCGCACCAGATCGGGCAGCGCCGGGACGGCGTCGCCGAGGTCGGCGGGTGCCACCGGGTATCGGCTGTCCATGTCCGTGCACGTGGGCAGCGGGGAGGCGCCCTCCCGACGCTCCACCAGCTCGTGCCAGTCGCGCTTCTGGTCCTCCACAATGTCGCGGTAGGCCCGGTTCTCCGCCTCCAGCGCCTCCTTGACGACGGCGAGGCGCTCCAGTGACGTCGCGGTGATCTCGTGTGCGGAGAGCTGGCGTTGGAGCCGTTCGTTCTCCGCGGCGTACGTGGCGCAGCGCTCTCGCAGCCGCCGCGCCTCCTCCTCGACGGCGGCGAGCCGCAGATCGGTCTCGGCCGGGGCGGCAGTCAGGCGCAGCCGACGCAGCTCCTCGCTCTCCGCTCGCAGTCGGTCCAGCTCCTCCCGCACCTCCTGCGGGTCGCGGTCCTCCAACGCCCGCCGCAACCGCTCGTACTCGGCGAGCCGTTCGCTCTGCCGGTCGGCGTCGGAGCGGGCGGCGCCGTAGAGCCGGCGCAGATGGTCGGACTGCAACCGCACCTCCTCGGTGGCCGCAGCGACGGAGAGCGTCGTCCGCTCCTCGTACATCTCCTTGGCGTCCTGCAGGTCCTCCTCCCGGATTCGCAGCTCGTTGTCCCAGCGGCGCAGGCGGTGCCGTTCCTCGGCGAGGGTCGCCCGGTCAGTGTCAAGGGAGTCGCGTTCGGCGGCCAGCTCCTCGCGGATCCGCACCCGCTGGCGGGCCAGTTCCTCGTCGAACTCGTGGCGGGTGGCCTCGAACCGGTCCCGCGCCGCGCTCAGTTCGGCGCGGGCCGACGCGACGATCTCCTCCTTCTCGCGGTCCTGCCTCGCGGCGAACGCCATCTCGCGGTCGAGCAGGTCCCGGTCGCGCGCGTCGATCGCGGAGGCCCGGGCAGCGAGTTCTTCCCGCGCGCTGGCCAGGCGGGCCTCCTCCGCATCGAGGTCGCCGCGCCCCACGGCGAGCGCCGCGGCGCCGCGCTCGATCTCCGCCGCCCGCGCGTCCAGCTCCCGGGTACGCCGCTCGATCCCGGCCAGGGCGTCCTGGTACGCCTGCCGTACCCGGGTGGCCTGCTGCCACAGGTCCACCAGGTCGCCGGGGCCGGGCGTCGCCGCGACCGGCTGCGGGGCGGGCAGGCTGTCGGCGCCCAGCTCGGCCTCGGCCGTCGCCGCCCCCGCCGTGATCGTCTCCGACAGCGGCGGCTGCGGGTGGGCCGTGGGCGCCGGCCGGGGCGCCGGCGGCCGCTTCATTGCCCTCTTGTTCCTGGCTGCCCCTCTTGCCATCAGAGGTGGGTCCTTTCGGTACGGGGTTCGGGCAGGGTCAGCAGCGCCCGGGTGGCGGCTGCGGCGCTCGCCCGGCACCACTGGGCGTCCTGCGGATTGGCGGCGTCCCGCCCGGCGTGCGCGGCGCGGTTGCGCAGAGCGTTCAGCGTGGTCAGGGTGACCGGCAGGTCGGGCTGCTCGGCGGCCATGGCGCGCAGCGGATGGTCGGCGTGCTCCTGCGCCGCCAGCAGCGACAGGGCGCACAACGCCTTGAGGTAGCTGTGGCCCTGACCCTGGTACGTCTTCGTCAACTCGTTCTCGGTGACCCCGGAGTAGAGCCCGGTCACCTGGTGGAAGCCGATCCGCTGGGCGGCCTCCTCCAGCATCGCCCGACGCAACGACCTGTTGCGGCGGAAGGACTCGAACGTCTCCGGGCTCACCGGGTACGCCACGAGCATCCGGCGGAACAGCACCTCGTACATCCGCAGGGTGGTGTGCGCGACCCGTTCGAGGTCCTCGTCGCGGTCCCCCGACTGGGCGGCCAGTTCGAGTTCGAGCATCAGGTCGAAGGCGTCCCGGTCACCGCGTACCGCCGGCCCGAACTCGTGGGCCAGGCGGCGCTCCAGCAGGTCCCGCAACTCCGCGCCCGCCTGCCGGTACTGGTCGCGGGCGACCACCAGCTCGGCCGCGGCCCGGCGGTCTATCTCCGTGTCGAGCAGGCCGTCGTCGCGACCGAAGCGGTAGATCAGCGACTGGAAGAAGTCGCTCGGACCCAGCCCGAACGGGTCCAGGGCGGTCCACGCCTCGGCGGTCTCGGCGCCGCCGTCCGACGGCACCACCAGGAACCCGGCGAGGAACACCGGCTCCGGATCGGCGAGGAAGGCGATGCGGTCGAGCTGGGGGGCCAGGTCCGCCCGGGCTGCGGCGCCCTGCGGACCGGCGATGTCACCGGGGGCGGCAGCCGGGGCAAGGCCCTGGTCCCGCTCGAACTGGCGTACCTGGAACACCCGCCGTGCGGCCCGGTCGGCGCTGGCGGCCTCCACCACCCGGGCCGCGCCCGGACGCTGAGGCCCCCGGGTGGGCGGCGCTGTCCGGTGTGCCACCGTCCGGTCGGACCGGCCGGCGGTGCCCAGCTCCAGTTCGGCGCCCACCGGGGTGAACCGCAGCACGTACGCCTCGCGGAGCTGATCGGCGGTGCGCGGCCACAGCTCGCCGGTGAACGGGTCCTCGAAGACGTGGCAGACCTGCCATTCGGTCAGCTGCGCCGAGGTGCCGGTCCGCAGCGCCTCCCGCCCCCGGTCGGTCAGCTCGTGCCGGCCGTCGAGGTGTCCGCTGCGCACCGACCGGTCGAGGATGTGGCCGCACAGCCGGGCGTCGAGTTCGACGATTTCGCCGATCCGGTCGAGCTGGCGAATGCCGGCCTGGCAGAGCGCCAGCGTCACCCGTTCGAAGAGGTCCAGGTTGCGCCGCTCGAGAACCGGTGCGGTGACCCGGTAGGCCCACGCCGGCCAGAGCAGGCAGATCCGCCCGTCCCCGGCCGGCGGCCTGCGGTCGTACATCAGGATCCGGGCCCGTGACCAGTCAAGCGACGAGGTGACCATGTGGCGCACCTTTCCGGCACAGTTCGAGGAAGTCGGTCAGCGGTGCGACGCCGGGCGGCGCGTGACCTGCCCGGAACATCGCGGTGGCGCCGACCGTGACGAGCAACCGCTTCTGCCGGCTCATCGCCACGCACAACCGGTTGCGCAGGGTGATGTGACCGTAGTGACGGGCGACCCAGCGGCCGTAGTCCTGGCCGGTGGGCGGCGGCGGGGTGTCGCGCGGGGGCGCGCACCGGGTGGTCGACAGCAGGACGACATCGAACTCCTTGCCCTGGAAGGCGTCCACAGTGCCGACCATGAGTCGGTCCAACCGCCGCCCGGCGCTGTCGAAGCGCAGCCGGTCGATCATCTCGTAGGACCCGCCGTTGCGGGTCAACAACTTGCGCGCGACGAGTTGCCGGCAGATCTCCTCCACCTGTGCGCGGTAGAACGTGATCACCCCGATGGTGAGGTCCGGCGCCTCGTCGAGCAGCCGGGCGACCTCGTCGGCCAGGACCGCCGCCTCGGCCGGCCGGGACCTGCTCCGATCGCCATACTCGGGGCCGGCCTGCGGCGGCACGTCCAGCCAGGCGGCGACCGCGCTCCCGTACCGGGTGAGCCCGTGCGCGAACGCGTCATCCGGTCGGATCGAACCCAGCGTCCCGTCGTAGAAGTTGCGGCTGACGAACTCACCGAGCACCCGGTGCATCCGGAACTGGGTGTCCAGGGTCACCACCCGCGGCACCGGCACTCCCGGCCGGTCCAGGCTCTCGAACAGCCGCTGGAACAGGCTCTCCGACAGCAGCTTGCGCATGTCCGGCTCGAACTCGCGTTCCACGTCCGGTTCGAGCATCTGGGGAAGCTGGTTGTGGTCGCCGACGAGCACGATACGACGACTGGCGTGAATCAGCGGGATCATCAGGTCGAGCGGGTTGGCCCGGGCCGCCTCGTCGACGATCACAGTGTCGAACACCACCTCGTCCACGCGGGACTGCCCCTTGGCGTCGGCCATGCTGGGCGAGGCCACCTGCTGGCAGGTCGCCGCGTACGAGGCGGTGTACTCGCGCAACGTCCACTGCACGGCGGCCGGGTCACCGTCGAGCGCCTCCCGGTACTCGAGGAGGGCCAGCGCCACCCCGTCGCCGGGTGACTCGGCCACCCGGTCGGCCAGGCTGTCCACCACGTCCTCGAGCAGCCGGCGCAGGTCGGGGTCGACGGCGGGATCCGGGTTCGGGCCGACCGGCCGGGCCAGCAGCTCCAGCAGGGCGGCGCGCGCCGGCGTCAGTTCGGCGAGGAACGGCGGCGGCTCGTCTCCGCGCCACTGCGCCGCCCTGGTTAGCAGGTCCAGCACCTCGGCCGGCACGTCCGCGCCGTCGAGCGCGCTGATCCGTCGTAGCGCCTTCGCGGCCGCCGCCGGCCCGTCGTCACCGAACGACTCACCGGTCATCCGGATCCCGCGAACCGCGCGAACCGCCAGTTCCTCGGCGTCCGAGGCGAACACGACGATCGGGCGCGGCGGCGCGCCCAGCCGATCCCGGATCCGATCGGCGAGCCGGCCGGGCACCAGATCGCCGGTGGTCTCCAGCAGCTCATGCAACATGACGGCCGTTCCGGCCGGGTCGGTGGGCGCCAGCAGGTAACCGGCGGCGAGCGCCGCGGCACGCCGTAGGGCGACCACGCCTCGGCCCTGAGCGCTCTGCCGGAGGCGTTCGTCCAGCGCGGCCACCGTCTCGGCCTGCCACCTGTCGACCTGGACGGTGGTGCCGCGTCCGGTCCGGTCGACCTTGTTGGCCGGCAGACCGAACACCGTCGACCGCTCCACCAGTTCGTCCACCGCGGCATGCTGGTAGCTGGTCAGCAACATCGACCCACGCAACCGGGCGTACCCATGGCCGGCCTCGGCGAGCCGCGTCTGCAGGGCCGCGATCACCTGCGTCTTACCGGTGCCGGGCGGGCCCTGGATGATCGCGATGTCCGGCGTGTTCAGCGCGACGTCGAGCGCCCGACGTTGTGCCCGGGTGGGCTCGCCGCCCCGGAAGACCTGCCACGCGGCCACGGACTCCGGCGCAATCCGCCGCTCCGGCAGGGGCGACGACACCGGGTCGCCCTCCAGCAGCGCGAGGAGGTTGGGGATGCGGGTTTGCGCCTTGAGCACCCGACCGAACGCCTCCCTGCGGCGCAGCAGCCGACGCCGGTCGCCACGGAAGGACAGGTACAGGAATCCGGCGGGGGGCGGCTGGGGCCCGGCCTGTCCGACCGGACCGGGGCGCGGGGTGGGACGCACATCGATCGTGGCCGCCGCGGCGTTGACCGCGACCACCTCGCCCGCGAACGCCTCGCTCGCCAGTTCGTCGTCGAGCAGCCCCCACGCCTGGTCGTCCGCGGCCGGATCGCGCAGGAGCGCCGGCGGCAACGCGCTGGCCGCCTCCAGTTCGAGCGGCGTGTCGTGCTGCTCGTCCGCCCGGTCGAGCAGGGAGAAACGGCTGGCATCCGATCCGGTCGGGACCGTGACGAGAAACCGCAGGACGCCGTCGTTCTGCCGGCGGACGGTGTCGTACTTCAGGTAGCCGGCGTCCCGCACGCTGCGGTGCGTCCACCATGCCTCCTTGCGGTTGTACGAGTTCCACATGGCCAGGAAGCCCTCGCCGGAGGCGAGCTTGCCCAGCTGGCGCTTCATCTCCTCCCGCAGGCGGGTGGCCTGGGACTCGTCGGTGAAGGTGACGGTGCGGTGGATCAGCGCCAGCGGCCCCTGGGTCCCGTCGTGGCCACGTAGCACCACCCGACTCAGCAACGCCTTATCGCCGACCGTCCGTACGTCGACCGCCACCCCGCGACCGTGGATGCGGAACGCGACCGGTTCGTCGGTGCTGTGTCGCGGGCCTGCGGAGATGACCAACCGGCCCGGCGCGTCGGGCGCGGAGCCGGGCAGCGGCGGCAGCACGAGCCGTTCGGTCAGCCAGTTCAGCGCCCACTCCGGGGGGCGGCGTTCGGCCCGGTCACCGGCCGCGCGGTGGATCCGGGTGAACTCCTTGTCCGCGACGCCAATCGCCAGCGGGGTCCCGGCCGGCCCCTTCTCGTAGAGATGGATGTTGAGGTCGAGGCGGGGCCAGGGGGAGCCAACCTGGGCTGGATCGAGGTAGAGAACCATCGCCACCCGGGCCTGCCCGTGGGTGAGCAACCGTTGCAGCGTACGGTCGTCGTCCGGGGTGGCGCCGGTGGCCATCGCCCGCTTGCCGGCGATTTCCACGACCACACTGCCGGACGGGCTGCGGCCCAAGACCGCCTCGGTCTCGTCGACCGTCACCTCGGGTAGGTCGCTCGACATTTGCCAGCGCAGCGAGACCAGGGTCGCCGCGCCGGGCAACGGAGCGAGCCGTCCCTGCCGGGGCCGATAGTTCTGACCGCTGGCCTGGTCGCCACCGCCGCCGCGGCCGCTGGCACCGGGCCGGCCCGCGCCGGACCGACGCGGCTGAGGGCGGCCCCGACCGCCGTCGAGCGTTGGTGAACTCATGCGCTCCGCTCCCGGACCAGATGATCGAATCTGAGCAACCGGTGGGCCTCGTGGGCGGGCCCGAAGTGCAGCTCCCAGGCCGCGTGCGAGGCCATCCCCGGAATGGCCGAGTCGTGGCCGGGCTCCACCGGCAGGCAGGGTCCGCCGCCCGGCCCGACGACCCAGATCGGACGGTCCCCACGATTGGCCACCGTAAGCCGGCCGGACCGGTCGAACCACAGGGTCGCCACGCCGCGCTCCGCGTCGCCGTCCGACGCCATCGCGATCCGGGCCGACACTGCCGTCTGGATCTGCTGCTGCACCAGCAACGCCTGCGTGGGCGGCCCGGTGACGGGTGCTCCCCCGCCCTGCGCCGGCACCTGGGTGAACACACGCGCCACGAGGGCGGGCGGGGCCGGGTCGGAGCACCAGGGGCAGGCCGGCTGATTTCCCAGGTACGAGCCGGAGCAGCCGGCGCAGGTGAGAGTCATATCGGCTGCCTCGTACAGCTTGGTGCGCCACTCGCCCACGGTCGGACGGGCAGCCGGGTCGGCCAGCCCCGCCTCGAACGTGCGCGCCGCGAGCGCCCGCAGACCGGGCGTCAGAACCAGGTCGCGGGCATGGCCGAAGCTCGCGCGGTTGGCGGGATCGGTTGGATGGTCCACCCACGGCAGCTCGCCGGCGAACGCCCGTTCCTCCAGCTCCGGTTCGCCGTCGTAGACGAGGTCACCGATGAACGGGTGCAGCACCGCAAGCGTTTCGAAGGCCATGACCCCGAACGCGAAGGCGTCGCTGAGGCTGGAGACGCCGAGCCTGCCGGTGAGAACCTCCGGCGCGGCATACCCGGGCGTGACGTAGGCGGACCCGCGGACCTCGGACATGACCGCGATGTTGTCCAGGTCGATGAGGTAGACGTGCTCGCGATCGAGGTGCGCGGAGACCATCACGTTGACCGGCGAGGGGTCGCCGTAGCACAGGCCCCTGGCGTGCAGCCCGGACAGCCCGGCCGCGGCCCGGCCGAGGAGACGCAACCGGCGTCGCAGCCCGCCCGTCCGGGTGTACCACCGGAGCACCTCGGTCGCGCCGCTGGGCGCGACCAACTGCCGCAGGGCCACCATGTCGGCGAGCATCGCCATGGTGTATCCAAGGTGCGGCGGCTTCAACAGGGTCAGCGGGCGAGCCAGCGGCAGGTGGTCCAGATCGAGTTGGCGTACCACGCGGAGTCGAGCGGCAAGCCGCTCGGCGGCCTGCTGGTCGCGACTGTGCAGCACCTTGACGGCGATCCGGCCGCCGGCCGCCTCCCACACCTCACCCTGCCCGCCGGCCCCGAGCCGGCGTGTCAATTCGATGGGCTGGTCGTCCTCCGTCCGCACGACGATCTGAAGTCCGTTGGTGTTCCAGTTCGGGTCGTTCGTCCGCACCGTACGCAGCTCCCCCGCAGACATCGTCAGTTCATGAAGCCCATCAGGTCATCGTTGGTGATCCGGCCGCTGCGTACCTGGGTCGTCACGGTGGCGGTGACCCAGTCGAAGTACCGCGTCAGCTCATGCACCTCGTCCGCCCGGCCCACCTTGATCAGCGGGTTGTCGATGAAGGCGTCCAGCACCGCGAACGCTTCGCCGTCCATCTCCTGACCGACGCCGACCGCCAGGCGGAGCGCCTTGGCGCCCCGCTCGGAGGCGAGCAAGCGCACCAATGGCTGCTGCCACTGATCGGTGGGAATTCCGTCGGAGACGAGGACGAGCGTCGGCCGGAACGCCCGGCGGGGCACGAAGGCGTCGTCGGCGAGGAGGTCGGTCACCACGTCGAGCGCCGCGCCGAGAGGAGTCCGCCCGGCCGCCGACATGTCCTGCCAGCGCACCTCACTCGCCGGTGCCAGCGGATGGTGCAGGGTCGCGCCGCGACCGCCGAAGGTGACCACACCCGCCCAGAGCTCCCCCCGCAGGGAATCTTCGGCGGCGAAGGCCCGGATCATCGTCGCGACGGCCTGGTTGAGGACGCCGATCTTCCCGTCATCCGCCATGCTGCCGCTGACATCGGCCAGAATCAGTACGGGCAGCGGGCGGGGGCGTTGGGCCATTACCCGGGCGGGCGGTGCGTCGACCACGAATACTCCTACGTCACTCTCTGGCGTCCATCCACATGGAACATCGCAGGATGCGCCTCGCATTCGATTCGGTCAAGGCATCCGAACCGAGAGTTGCTCAATGCTGGTCCATCGAGCGCAGCGATCGCCTCCCTCACCAGCTCAGGTTCATGGGCTACCAGCACGTGCGAAACCCGGCGTGCACACGCCCATCTGCCAGGGATTACACCGGGAATCGGCCAGTGCCAGCCTCCCGCCTTGGCCGGCCCTGATGAACCCTCCGCCCATCGCGGCGAACAGGATGTCAAATATCCGTCACATTGACTCGCGTCGCCCGAACGTCAGCTCGTCGTCGATGCCGGCGCCGGGCTGCTGCCCATACACGCGACCTGCTGGCCGCCTCGGCCGGCTACCGATCTACCGATCTACCGATCCAGGTTCTCAGGTCAGGGGCAGGAAGATCCTTCCACCGGTTCCGGCAATGCCGCGGCTACTGCCATGACCACGAACGTTGACGGTGTTGGGTGACACGGCGTCCGGGCTGTCGGCCGAGCGGGTCGCCGTCAGGAAGTCCGGTTCGGGACGTATTTTGCGCGGCCTACGATTCGGTGGTGGGTTCCTCGCTGACTGTTCGCTTGGCCCGGGTCGAGGACATCGCCCAGATGGCGTGTCGGAACGTGTCAAGGGATTGAGGCCAGCGGGAGTTAAGCGGCGTGTGGTTGCGGCTCGGGTTTGTTGATCCAGACCTGTTCGGGCAGGTCGAGGATCTTGGGTAGTAGCCGGGTGGCGCCGAACCGTTCCGGGTGCGTCGTGCGGGCTGCGGTGAGGGTGTCCTCGCGGTTGGCGCGGACGGTGTGGTGACGGCCGTGGTGGACGTCGGCGGGGGTGTGCATGCCGATCCCGGAGTGCCGGTGGGCGTGGTTGTACCAGGTCACGAACTCGGCCATGAACGCCCGCGCCTGGGCCAGGGACGCGAACCGGTCCGGGAAGACCGGCGCGTACTTCAACGTCTTGAACCATGCCTCGCTGTACGGGTTGTCGTTGGAGGTCTTCGGCCGGGAGTGCGAGCGGGTGACCTGAAGGTCTTCGAGTAGGTCAGCGACCGATTTCGAGGTCATCGAGGTGCCCCGGTCGGCGTGCACGACGTGCGGGACACCATGGGTGCCGAACACCTCGCGCATCATCGACTCCGCCAGGGGTCCGGACTCGCGGGCGTGCACGCGGACACCGATGATGTACCGGGAGTAGATGTCGATCATTACGTAGGCGTCGTAGTAGACACCCTTGACCGGTCCGGCAAGCTTCGTGATGTCCCAGGTGTAGACCTGCCCCGGCCGGTCGGCGATCAACTCGGGACGCCGCCTGGCGGGGTGCCGGGCCTGCCGGCGACGCTCGCGGACCTGCTCGTGTTCGCGTAGGAGCCGATACATGGTGGCGATCGAGCCCACGTAGACGCCCTGGTCCAGCAACGCCGCGTAGATCTGCGCCGGGGCGGCGTCGACGAACTCCGGGCTGTTCAACAGCCGCAGCACCTGCCCGCGCTCACTCGGGGTGAGCGCGTTCGCCGGCGTCCGCCGGGCCGGTCGCGACGGTGTCGGCCGGCGCCGGTCCCGGTCCGCGCTGGACCGGGCGATCCCGGTCATCGCCGCCGCCTGCCGAGTCGTGGTACCGGTGCTGGTCAACTCCCGGTAGGCGGCCATCAGCGCTTGCCGAGCCCGAACACGTCCGGACCGTCCGGCTCGCTCCTGGAGATGTCCTCCAAGAGCTCTCGCGCTTTTCCCATGATCGTCAACGCCGTCTCGGTCCGCGCCAGCCTCGCCTGCGCCTGCGCCAGTTCCCGCCGCAGCCGGGCGATCTCCGCCTGCTCCGCCGACGGCCGCCCGACCGTCTCCCCGGCCGGTTTGCCCTGCAACAGGCCGGCGTCACGGGCCCGGCGCCACTCCGACATCAACGACGAGTACAAGCCCTCCCGCCGCAGGAACGCCCCGCCCTCACCGGCCGCGACGGCCTGCTCATACCCGGCCAGCAACTCCAGCTTCTGCCCCGGCGTGAACGACCGACGTGCCCGCGGCCCACCCGAACGCGGACCCTTCCCACGACTCATGACCCCATCCTGAGCCACAACCATCTCAACAGCAGTAGTCAACGAATCTCGATCCTGAACTCGCCCTGTCCAGCGGACTTGCTATGAACCGCTGGCCTCAACTCACCCTGACAGACAGGGTGTGTGCATGTTCGGTGCTGGCAGGAGACGTATCGGGGACTCATGTCGGATGCGGTGCTGGATGATCCGGGTTTCCCGGCTGCTCGGGAGCGGTTCTGGACTGCCGCTTTGACCGATGAGCGCTATCGCGAGAACCGGGTGGCTGTGGCCGAGCGGGCGGGCGAGTTGATTGGGATCGCGATGTCGGGGCCGCCGCTGGACGCTGTGGGGGCGTGGGCGTGGCAGCTGTATGTGCTCTACGTGTATGCGGCCAGGCACGGCACGGGTGCTGGGGGTGCGTTGTTGCAGGCCGTCATCGAGCCGGCGGAGTCGGCGGGGCTGTGGGTCGCCGATCCGAACCCTCGCGCGCAGGCGTTCTACCGCAAGCATGGTTTCTCTGGCGACGGGACGGCCCGGGTCGAGGACGGCGTGCGGGAGATTCGCATGGTCCGCGACGTGCAGCGCCGTCGCTGATGCTGTGAACGATGACGTTTGGAGTCTTGGGTCAGGCTGCCCGGGTGGCGGGTTGGCCCCAGCGTTGTTGGCGTTCGCTGCGGATGCGGGCGCGTTCGCGGCGTTGGGCGGCCAGGATGTCGGGGTGGCGGGCGTTGGCGTTGCGCCAGTGTAGGTATCGGTGCAGGTGGCGGGTCAGCGTTGGGTGGTTCGGGTGGTTCGAGCCGGCGATCACAAAGGCGCGTAGGGGCCCGAACTGGGCCTGGATCGGGTTGGCCCAGGAGGCGTAGGTCGGAGTGAAGCAGAGTTCGACCTTGTGCCGGGCCGCCCACGACCGGATCTTTCGGCCTTTGTGCGCGGACAGGTTGTCCAGGATCACGTAGATCGGCGCGCCGTCCGGCCGGGCGGCGCGGATCGACTTGAGCGCCGCGAGGGTGTTCGCGGCGCTCTTACGCCGCCGCATGACGCCCCAGAGTTGGTCGTTGCCGACGGAGTAGCAGCCGTGGAACTGCCGGACCCCGTGCAGCTTGTGGTAGTTCGCGGGCAGTCGGTGCGGCTGCCCGGCCGGCGCCCACCCGACCCCTGCCTGCGGCCGGATCACCAGGGGACCGAACTCGTCGAACGCGAACACCCGCTGCGGGAGACGTCTGCTGATGTACTCGATTCGGGCGAGTTTGGCGTCACGATGCGGGTCGGTGGACTCCTTCCACGTCTTGGTCCGTTGGAAGGTGATCCGATGCCGGTGCAGGATCTGCTGCAGTCGTTCCCGCCCGATCCGGAT

Protein sequences of DBSCAN-SWA_2

>NZ_CP022961|4314164:4380006|4314164_4314986_+|WP_095565896.1|transposase|DBSCAN-SWA
MSVTYTAVLPVREHTVGVLAGLLTTERARRGTRAGTRALPCRDQAVLILRWFLDSTRMRQLARDNAISLSTSYDYLHEGIDVLAARSPTLHGALLAAKAAGHDYVNIDGILVETDRCRTPGPTEGVDLWWSGKHDNHGGNVQVVTVPDGWPIWTSGVRPGREHDTTAVRTHAEILPALTAAGSDLRTLGDLGYEGESGTITVAFKKPKNAKLSLVQQQLNKAHNSLRAIAERGNSLLKMTFKALRNVSLNPWRIGKIVAAALAVLHIEHDRTT
>NZ_CP022961|4314164:4380006|4369433_4371014_-|WP_095565922.1|DBSCAN-SWA
MVTSSLDWSRARILMYDRRPPAGDGRICLLWPAWAYRVTAPVLERRNLDLFERVTLALCQAGIRQLDRIGEIVELDARLCGHILDRSVRSGHLDGRHELTDRGREALRTGTSAQLTEWQVCHVFEDPFTGELWPRTADQLREAYVLRFTPVGAELELGTAGRSDRTVAHRTAPPTRGPQRPGAARVVEAASADRAARRVFQVRQFERDQGLAPAAAPGDIAGPQGAAARADLAPQLDRIAFLADPEPVFLAGFLVVPSDGGAETAEAWTALDPFGLGPSDFFQSLIYRFGRDDGLLDTEIDRRAAAELVVARDQYRQAGAELRDLLERRLAHEFGPAVRGDRDAFDLMLELELAAQSGDRDEDLERVAHTTLRMYEVLFRRMLVAYPVSPETFESFRRNRSLRRAMLEEAAQRIGFHQVTGLYSGVTENELTKTYQGQGHSYLKALCALSLLAAQEHADHPLRAMAAEQPDLPVTLTTLNALRNRAAHAGRDAANPQDAQWCRASAAAATRALLTLPEPRTERTHL
>NZ_CP022961|4314164:4380006|4339892_4340963_-|WP_157756850.1|DBSCAN-SWA
MASRKQQAARRRGATQHTRRPKIAPPDGWLSDDRWLEWAGDYGLDLRDRDQLLDAAAVGLTVLCWRNTALEDVHAGVERHQRLEQLGKDPDDPEVQAEERRARREHYELLDANWKVLADVDPDESARIDVFLDGREQGFGIPDDIMMRLNISTALDVRDMLDDILPNSITQPGTEIVYDRRSVPDHIAALVELMQDPDRELTVGGSTVTASEVLGETWDEYADDVMRKVTTHVKVTDLIGARRALWYTGLSGIIYASAWFPNPWWSRAVDLLRAAIADNRAAEVLYSPERMGDTPPLDDEFWQTLLARPAELTGPQCAWIQGTRLGDLIRTVRDSDRQRLGPLKDEGRFFGLAVMF
>NZ_CP022961|4314164:4380006|4328271_4329228_+|WP_095565903.1|DBSCAN-SWA
MAAVPHRVRRERRRPVLRPGAPGARSGTRWPWSRPRPCQRLVLDRQRDRPPRRSPLGGALLVLTSFHTVVVADAATYLISALLVLAVRRVSVPAVRAEADETPATGALAEFRAGAAYLFRHLLLRALLLTSSSFLLVNAAFTVLLVPYLVGRLGADGEQVGLLLSALGIGFLISAYVGRAISRSGRLRYGAAGCLAAVTVTFGGLFGWHDLVAAAVFLALAGVPGGAFLLLIEVQVQRQTPDHVLGRVSAAFSSTEMAATLLGGLLGGALAAAVGLMPTVAVLLILLALVAAAALVVLPDKVVAPDAAPIEPERTSVE
>NZ_CP022961|4314164:4380006|4365007_4367095_-|WP_095565920.1|DBSCAN-SWA
MTRTERLYDRLTGRVVPAYPPPSAATLGRYARHTAAPDVFSVDFDIGSPSRRRAALPDAVTVAAVLAIGERVAGLVRRGAPLGALVEVSPMVDGGYAQRMLSRQSLEAAIDEHLPYLRAVCFRPAARLRSVDRQVPVARARTVTTRSIVRLAAHSEDWAARRPDGVRPDRVLSPERETDLDLYENRVVARLVAELSRYLSLRMAQIRSLGSMFSDIQRYIDDISGRPWQTSLRLWELVAALVDQADWKTQAQLRLAELEQLSSAVSALRGSPLWRGVNRQAALGTTLRSTNLFGGEERYRHVAELWRRLVATRADSESADEAARHTRRWCEGFVRYAWVLAVRAFDELGATPVEPAAATGPMRYQLRATAMSLRVDRGGVFLIERDGAPVLRVVALPHALTASRTGDAVAAEMKRLTTVVPNVPTVVLYPGSREERQELPVQVRLRVYESPATPAPDHSGAMLWPIPVSPLEVDSVVRLARAVRWLVEQPRFAGYPYAVPCGATTAGDVVSDIPWLAAAADGIAVTRVPGPHELVSARMHLMAIQRGTARFRRLGSNESELENLWDGIEQAVERTVELTRCPRCNARPEQPERALRPRAENCFHVSCTSCGAAWESRRCRTCTRSYPVLDTAGESPKTPDGDCIDQWYGTDLLVARCMTRSRVFICPWCATCANVRSDKNCPRCYAATGSVDPIA
>NZ_CP022961|4314164:4380006|4361895_4363095_+|WP_095565918.1|DBSCAN-SWA
MSWLPVNLAELDKTGVRRQLDDDTASALSSTGLVEVRPEGGGWWHLLPAGKVGAVRIGGLDVQVQPKVGIARLLFLLGYALDPGFRPEDVTAIPEPDLWPALAESLIRQAGRALAPGVLQGYVSVDESLPLVRGRIRFADQFARRPGIPLPIEVRFDEYAADIAENQILRTALRRMMAVPRLPAGARARLAHLDGRLDGVRVLPHGAPLPAWRTSRLNARYAPALRLAQLVLRYQSAEPGPGDVTVAAFVVNMAKVFEDFVTTALRVALAPYPGHTDGQYPAHLDVDRTIPIRPDVVHVVNGQPVAVFDAKYKLEGASSGFPNADAYQMLAYCTALKLRLGWLIYAQGTSAPGRRRIRNTEIDVVHYPLDLAAPPRQILVEIDVLAHKAMQKHAVTEDR
>NZ_CP022961|4314164:4380006|4379277_4380006_-|WP_157757014.1|transposase|DBSCAN-SWA
MRIGRERLQQILHRHRITFQRTKTWKESTDPHRDAKLARIEYISRRLPQRVFAFDEFGPLVIRPQAGVGWAPAGQPHRLPANYHKLHGVRQFHGCYSVGNDQLWGVMRRRKSAANTLAALKSIRAARPDGAPIYVILDNLSAHKGRKIRSWAARHKVELCFTPTYASWANPIQAQFGPLRAFVIAGSNHPNHPTLTRHLHRYLHWRNANARHPDILAAQRRERARIRSERQQRWGQPATRAA
>NZ_CP022961|4314164:4380006|4337488_4337971_-|WP_157756848.1|DBSCAN-SWA
MSSPAEGAERSVAPSDEPEVIILSLTDDRAIMIDAPSGTTRSRWGRRVADFTTEELASLLRTLDPAMKSFIESRRLTGGLVELDHISRAMWSTAELITEEGGWIQATLRSRGQVARLMRIRPATGVAAATGGAAILGGIATQAQAAEMARHINLPWSGGI
>NZ_CP022961|4314164:4380006|4330282_4331782_-|WP_095565904.1|DBSCAN-SWA
MKILDETSRTLNEYLLVPNLTTEDCVPGNVDLSAPLSRHRIGEEPAIRIATPLVSAIMGAVSSPRMAISLAQCGGLGFIHHNQPIAQQAEMVSGVKRHKAGFRHSDINTTPSATLGEVTNLLEAAERDVAVVTDDGTGTGTFLGLISTHDFHPKRHNLAEPVSTRMRATDSLVTAPPTIGLSEANSMIWDHRLDVLPIIGDDGRLHAIVLRRDYELHKTFQTETIDDSKRFRVGAGINTHDYADRVPALLDAGADLLCLDSSDGYSVWQAHALNHIKKDLGSSVPVGAGNVVDGRAFRYLADAGADFIKVGIGGGSICITRDQKGIGRGQASALIDVVAARDAYAADTGTYIPLCCDGGLLNDYHMAIAFALGTDFIMLGRYFARFDESPSRLVRVGGQLFKEYWGEGSRRARNWARYDQGGNQLVFEEGVDGYVPYAGSLYDNIALTIAKLKATMISCGSTTLRGFHDNAVLVPVSHQSYLQNAAEIQLRDRPADPTQ
>NZ_CP022961|4314164:4380006|4321349_4321907_+|WP_095567947.1|DBSCAN-SWA
MGHLGITPHHLAHRQKPVAFVDLVHGGRTYQNLFHLLRGWISEERAAWSVIRTKLRFIGITARTKTSPNTWRWYQAAPWAAYLPRNALVSVSLGQRVWGYLADHQHKITRSFPVNRWLDQDTRLPARDPTALAALAEAVSLVAHGRSPEGRTALTAAITDEPTMHQPWLRFLVTELRRPTTSRQG
>NZ_CP022961|4314164:4380006|4378835_4379246_+|WP_095565926.1|DBSCAN-SWA
MSDAVLDDPGFPAARERFWTAALTDERYRENRVAVAERAGELIGIAMSGPPLDAVGAWAWQLYVLYVYAARHGTGAGGALLQAVIEPAESAGLWVADPNPRAQAFYRKHGFSGDGTARVEDGVREIRMVRDVQRRR
>NZ_CP022961|4314164:4380006|4325187_4326273_-|WP_095567532.1|transposase|DBSCAN-SWA
MPQEGQTETGDHEVVLGVDTHKDVHVAVVLTTLGVLLAGRDFPTTKSGYRDMVMWARSYGPLRLAGVEGTGSYGAGLTRLLRAAGVHVIEVNRPDRSVRRRRGKSDAVDAEAAARAVLAGDATALPKTADGLVEAMRIFKTAKDSAVKARVQAINQLKAIVVTAEPALREALALLNTSRLVARCCQLDVDAQDAVTAASLYTLRQLARRIQHLETEIRDLQHRIAGAVQSTAPELLRISGVGPDTAATLLIAAGDNPGRLASEASFAALCGVSPVEASSGKTQRRRLNRGGHRQANAALYRAVLIGLRWNPRTRDYMQRRTAEGLSKREIIRCLKRYLARAIYRIIIASMTPTTPPQPSTA
>NZ_CP022961|4314164:4380006|4339028_4339826_-|WP_157756849.1|DBSCAN-SWA
MSVAEVGAALRAILDSISRERGRTAGVVRDLQDSRSRLGVTLRGSGHPLVGRALAGFAAAIERLREADHLAAQSAEAVRAYAHAIGIDIPASSSQSADNVGQTGTSAQRSAGGVPPTQGQGWVEDAVGRLPRRPGGKGPTHGLLFDTSGTPLTGPPLTQSEGYLRSGGAPGARDGLRPDWHPLAQVTREHVEAHAAALLRRPGAPREAVLVVNKPTCVSKGEYVGCDEVLPGMLPRGSRLAIYVSDGAATRLLKVYTGTGEGIAS
>NZ_CP022961|4314164:4380006|4315956_4316370_-|WP_157756846.1|DBSCAN-SWA
MNEDELLHRYGLQPAAEHLDQIRDLLTAQTERERQSQGYGDTEVMKLCCVQLFNAGVMSDVLTIWRAKSSSWDAFCSVDVQLLCGGGLAETKGYLLTVGSEDAVQALDHLGRSEAAGGFADFSVERQVSSYADYYHA
>NZ_CP022961|4314164:4380006|4342554_4344009_+|WP_157756852.1|DBSCAN-SWA
MRAHVLHEPQLEFRAGNRHIDPRYGISAYGPADAESPSAPRQIPIAFIGPSHAVDGIRRWLQRCREQIEAKNAKPGQENLHQPFPGFSPDSEFGSELVFDDALVREIPERQLRRLARADTASATAEAVQTYADAARSLAETGRCRVIVCARPEELLDRESRPPAAEDDGADHDRDPDERESSGDFHDLLKAAALSLPAPLQLMRKETWTGQPTKNSGQAARPLQDEATRAWNLHTALYYKAGGTPWRMQRHTSDLATCYVGISFYRTTSGQELHTAVAQVFNERGDGVVVRGGTAQISKTDRQPHLAQADARRLLVDALAEYRGTHGHQPARIVIHKSSSFTDTEVEGFHAAADERDIDHLEMLWIQRRGAPHLFRTGQLPPLRGTSVQLDQRSLLLYTRGSVPYFRTYPGMYVPQPLLIRPESANTDLLAAGTDVLALSKMNWNNAQLDERDPLTLRTAYRVGAILKHVPDGARIATRYAYYM
>NZ_CP022961|4314164:4380006|4370994_4374504_-|WP_095565923.1|DBSCAN-SWA
MSSPTLDGGRGRPQPRRSGAGRPGASGRGGGGDQASGQNYRPRQGRLAPLPGAATLVSLRWQMSSDLPEVTVDETEAVLGRSPSGSVVVEIAGKRAMATGATPDDDRTLQRLLTHGQARVAMVLYLDPAQVGSPWPRLDLNIHLYEKGPAGTPLAIGVADKEFTRIHRAAGDRAERRPPEWALNWLTERLVLPPLPGSAPDAPGRLVISAGPRHSTDEPVAFRIHGRGVAVDVRTVGDKALLSRVVLRGHDGTQGPLALIHRTVTFTDESQATRLREEMKRQLGKLASGEGFLAMWNSYNRKEAWWTHRSVRDAGYLKYDTVRRQNDGVLRFLVTVPTGSDASRFSLLDRADEQHDTPLELEAASALPPALLRDPAADDQAWGLLDDELASEAFAGEVVAVNAAAATIDVRPTPRPGPVGQAGPQPPPAGFLYLSFRGDRRRLLRRREAFGRVLKAQTRIPNLLALLEGDPVSSPLPERRIAPESVAAWQVFRGGEPTRAQRRALDVALNTPDIAIIQGPPGTGKTQVIAALQTRLAEAGHGYARLRGSMLLTSYQHAAVDELVERSTVFGLPANKVDRTGRGTTVQVDRWQAETVAALDERLRQSAQGRGVVALRRAAALAAGYLLAPTDPAGTAVMLHELLETTGDLVPGRLADRIRDRLGAPPRPIVVFASDAEELAVRAVRGIRMTGESFGDDGPAAAAKALRRISALDGADVPAEVLDLLTRAAQWRGDEPPPFLAELTPARAALLELLARPVGPNPDPAVDPDLRRLLEDVVDSLADRVAESPGDGVALALLEYREALDGDPAAVQWTLREYTASYAATCQQVASPSMADAKGQSRVDEVVFDTVIVDEAARANPLDLMIPLIHASRRIVLVGDHNQLPQMLEPDVEREFEPDMRKLLSESLFQRLFESLDRPGVPVPRVVTLDTQFRMHRVLGEFVSRNFYDGTLGSIRPDDAFAHGLTRYGSAVAAWLDVPPQAGPEYGDRSRSRPAEAAVLADEVARLLDEAPDLTIGVITFYRAQVEEICRQLVARKLLTRNGGSYEMIDRLRFDSAGRRLDRLMVGTVDAFQGKEFDVVLLSTTRCAPPRDTPPPPTGQDYGRWVARHYGHITLRNRLCVAMSRQKRLLVTVGATAMFRAGHAPPGVAPLTDFLELCRKGAPHGHLVA
>NZ_CP022961|4314164:4380006|4327004_4327979_+|WP_095565901.1|DBSCAN-SWA
MEDLESAYKALRDGRPVRLPARTTSFRRWSQALRRHALSRPVCDQLPYWQAVPNGDATAVPGRSGGANLVAQRATVTAVLDAADTARLTYDVPRAAGVSVHQLLLTALLVAWHGEFGCTALQVDVEGHGREPIDAGPDVSRTVGWFTSVYPVTFDIVAGGDPLAVLAVVRSRLDAVPDRGLGYGLLRYCADPEIGERLSALPQSQLSFNYLGRFEGPSDEGAVFGVPLEIPTVLQRPEAPRRYQLEVAATVAAGQLTLEWVYGTESLDQATVRSVLDRQVAAVRTLAERLLADPRAAGRSGTPFPLASLSHDQLAAISRRTVGR
>NZ_CP022961|4314164:4380006|4367094_4369401_-|WP_095565921.1|DBSCAN-SWA
MKRPPAPRPAPTAHPQPPLSETITAGAATAEAELGADSLPAPQPVAATPGPGDLVDLWQQATRVRQAYQDALAGIERRTRELDARAAEIERGAAALAVGRGDLDAEEARLASAREELAARASAIDARDRDLLDREMAFAARQDREKEEIVASARAELSAARDRFEATRHEFDEELARQRVRIREELAAERDSLDTDRATLAEERHRLRRWDNELRIREEDLQDAKEMYEERTTLSVAAATEEVRLQSDHLRRLYGAARSDADRQSERLAEYERLRRALEDRDPQEVREELDRLRAESEELRRLRLTAAPAETDLRLAAVEEEARRLRERCATYAAENERLQRQLSAHEITATSLERLAVVKEALEAENRAYRDIVEDQKRDWHELVERREGASPLPTCTDMDSRYPVAPADLGDAVPALPDLVRRVRALIRQQHGLFYEEADLRSFLGGLATSQLHLLQGISGIGKTQLPQRFAEAIGATSAVVSVGADWRTPQDLMGYYNAFERRFYESEFTKALYQAQCPQFAAQPFFIVLDEMNLSHPEQYFNDVLSALERRASRDATPDLVLMSAGVTPAPRLLREGRLLPVPRSVFFVGTANHDETTVSFADKTYDRAHVVELPASPQPFDVDPQDPLPRLSFAALSQAFDAAAAARRASADRTRQFLATVLAERMATDFRVSWGSRLYQHVDRYVPVVLAAGGSLTEATDHLVATKILRKLRGRYEIRVDQLRRLRDELAASWPKLGDEACDGQPRRSLAALDDLVRDLGHQ
>NZ_CP022961|4314164:4380006|4344230_4345403_+|WP_095565913.1|DBSCAN-SWA
MPSPEAPISADRYITEVTRRRLLDGLGWLRDTVPNGIREFLTPAHTFWSGALPETDFLARLYDLDQLPSHDSRYTTAFQDIVQHRVMNEDWEDDWIFSDPRFGLADNDEALLRLLAEMLHPAVRTDPAEVDRLREFLNDVLVHDGYELVQVDDISGAPLFAPRRIGGGVRGTMKNLIFAAIGPKPDIMLVDAINNDLRITGNVQGCLMYDRPLAAHGLTWAELTAWWADREGMTGADAREVSSSLYRRLDRSLGDNDAERRVLRTYADRYLRLGPDIPALVPQVYLHYDPHVRSHYRPGAAPLPRQRMDFLMLLPHWARVVIECDGRQHYADDNGRASPRRYAEMVAEDRELRLTGYEVYRFGGAELIDGPDTARRLNTFFDRLADRHPA
>NZ_CP022961|4314164:4380006|4320107_4320593_+|WP_095565898.1|DBSCAN-SWA
MINAPVTLYWRPTLLDQTIAWLDQHGYQIVQLDAARWETEDDLHRDVADAFDFPDYYGHNLDALRDCMSDVTDGEYGWNTDRTGLVVVFRGYDRFARSCPRAAQLVLDIIAEQSRTALLFGRRVMCLVQSDDPDIRLTPVGATPAAWNDAEWLDSARHPDR
>NZ_CP022961|4314164:4380006|4316385_4316739_-|WP_095565897.1|DBSCAN-SWA
MAETTILWRPTGPEELELVRASGWKAWPPRLPDQPIFYPVLNEQYAIMIARDWNVPASGIGYVTRFEVDREFASRYPVRQAGGRDILELWVPAEELDEFNRHIVGLIEVVHEFRPGS
>NZ_CP022961|4314164:4380006|4323758_4324580_-|WP_095565896.1|transposase|DBSCAN-SWA
MSVTYTAVLPVREHTVGVLAGLLTTERARRGTRAGTRALPCRDQAVLILRWFLDSTRMRQLARDNAISLSTSYDYLHEGIDVLAARSPTLHGALLAAKAAGHDYVNIDGILVETDRCRTPGPTEGVDLWWSGKHDNHGGNVQVVTVPDGWPIWTSGVRPGREHDTTAVRTHAEILPALTAAGSDLRTLGDLGYEGESGTITVAFKKPKNAKLSLVQQQLNKAHNSLRAIAERGNSLLKMTFKALRNVSLNPWRIGKIVAAALAVLHIEHDRTT
>NZ_CP022961|4314164:4380006|4364151_4364295_-|WP_157756853.1|DBSCAN-SWA
MSAILPGQPLLLAALVVHDLLVIHPASTVTRLLTDLHAQAIGGRRVC
>NZ_CP022961|4314164:4380006|4355549_4359647_+|WP_095565916.1|DBSCAN-SWA
MSGPGLQGIHAVGGVVPPGLLARIQAGELKDPAGLAPASYHLVGRETVRDAASRAWSYLRGAWTAWREHTATQPPGTHGIAAARERWLLVLLRELGYGQVPALPAGYTIDERHYPVSHAWQHVPIHLLGPGVDLNHRNADVPGAARAPQAMLQELLNRSDAHLWGILSNGLRLRLLRDSTALAGSAYLEFDLETIFDGELYPEFLLMWQLCHVSRLEQRPTDVDTAASPAGCWLEVWRGEAAEAGTRMLDRLRDGVADAIAALGTGFIRHPANRPLVEALRSGTLSTAQYHRALLRLVYRLLFCFVAEDRDALLHPNATAQARDRYSRYFSTARLRKLSRSRAGSPHPDLWQAQTLVLRALGGHGHPGLGLPPLAGLFDPDPHLPTIDRLPADPLLGCELTNEDLLTAVRKLAWVALPGQRVQPVDYRNLGAEELGSVYESLLELVPRVDLTDRTFQLVTVSGNDRKTSGSYYTPPSLVSALLDTALDPLLDEATADASSPTDAETRLLALTVCDPACGSGHFLVAAARRIARRLAQVRSGDDEPTPAQIQHALRDVVGHCIYGVDLNDLAAELAKVSLWLEALEPGKPLGFLDARIRIGNSLLGVTPALLHGPVPDEAFKDLEGDDKKTAAAVRKRNKAQAVGKDGYAQDLLFVGGPAISNADLAAQRTALLDLPEDVDSVRAQADRWEKHEQSPEYRAQRLHADTWCAAFVWPMPEPGTGSVPEPPTNAIMRAIADNPLSQVHAHLTEYAAQIAAQYRFFHWHLEFPEIFHVDHATVDATLRGWNGGFSCVLGNPPWERVKLQEKEFFAVRHPEIANAATAAARKKLIAGLQNSESAADRALHEEWTAALRVSDGTSALIRRSARFPLTATGDINTYAIFAEAALSIMSPTGRLGIILPTGIATDATTQRFFRELITRHSLVSLYDFENEEKIFADVNNRPRFCLLCLTGKQAGRISLAFRLRQPSQISDHAYEITPDEILLLNPNTGTCPACSSRRDAEIAIDIYRRIPVLWLEGEVDGNPWGLSFMRMLDMSTDSGHFVAAAKADSDGWSRKGGYYRRGHESLLPLYEAKMLHHYDHRFSTYEGATQAQINKGTLPRLDDTAHADPLAHTLPQHWVPESVVEERLASDPKRARPGWSHDWLLGWRDVARVTEERTFITTVIPRVAVGHKYLLALPREGSIACLHANLSTFIFDYVARQKLSGASMSYFITKQLPALPPSAYRRGVPWCDSNGNLESWIKVRVLELSFNSYDMRGYARELDDEGQPFVWASGRRELLRAELDAAYFHLYGVGRSDVDYVMDSFNLVRKDDERIYGDYRTKRMILEIYDAMQHAINTGKPYTTIVDPPPGHGARHPARDEALA
>NZ_CP022961|4314164:4380006|4359643_4361899_+|WP_095565917.1|DBSCAN-SWA
MSDSQVILPTRNDGLVRQVGRELIEQGFQHGRSLFTPERSVWNPDTAGELHRRYNEQPDLGVDPFLVKLRRQLGSASDDAIQLAAELLTLQGLPLVNLTTATLHARVTAVLGWMREPVTVPDHVLAAFTQGTWNGGIGAHTMLWKWLADAVELVCGWWSLPQDQRERAFADPWAWQDAVYQYKLMPSLREELLYLRFPSYFLPILNMAHKKAIRDAFADPTTPSTGDLNRDLFATTVRIQGQLGQPVDFYQQPFVAQWRKQAERPPGERRAWLVRPRQGGHDLVERWSAESFVSLAASHLGEVSPGASRAEVRAAVEAGYQHLDYAQRVSLANEYHAFLSQMDSDDVVVTLVDDQLYVGVLDGDPEYSPTDGGARLRRAAGWLASAPIAVDALPAPLPAELDQQGTVVDLTGALDVLAGLVEVDAETLEAPSPPDRMQPTVRVVPKLPAVTDALATRLYIDRAWLHDLLGLWQERSQIVLYGPPGTGKTYLARALAAHVAERDAVRLVQFHPSYAYEDFFEGFRPIEGADGGPVSFAKTPGPLREIAAEARNNPEKPYVLIVDEINRANLAKVFGELYFLLEYREATIRLQYSPSEAFNLPPNVFIIGTMNTADRSIALVDAAIRRRFAFIELHPDDPPVRDVLGNWLTANGKDGDERAVLLAALNESIGEEDHDFKIGPSYLMKPNLDSEAALDRVWRYDLMPLLEEHYYGRLTRTQIRNRFGLAAIRARIIPANSGASPSTADEAPPSE
>NZ_CP022961|4314164:4380006|4375930_4376563_-|WP_095565925.1|DBSCAN-SWA
MAQRPRPLPVLILADVSGSMADDGKIGVLNQAVATMIRAFAAEDSLRGELWAGVVTFGGRGATLHHPLAPASEVRWQDMSAAGRTPLGAALDVVTDLLADDAFVPRRAFRPTLVLVSDGIPTDQWQQPLVRLLASERGAKALRLAVGVGQEMDGEAFAVLDAFIDNPLIKVGRADEVHELTRYFDWVTATVTTQVRSGRITNDDLMGFMN
>NZ_CP022961|4314164:4380006|4335968_4337366_-|WP_095567477.1|transposase|DBSCAN-SWA
MVVGSDGKGLVGHAGAVLLRKCADRTGLTSALNKVLPRGKGPGWWDRGTVLVCLAVVITLGATSMSDIGLLAHQRLVFGDRPSESTVRRALAGLNEKVLKRVGKARAKVRAHVWALLARRPQGFPWLTVAGKLLTGWVVIDMDATLITAHSDKQGAAATFKKGYGFHPLGAWCANTAECLAMLLRPGNAGSNTVADHIRVLGDAIAQLPAGYRRKLLIRVDGAGATHELLEHLERMNRVWRSVRFTVGWTITAADETAIEQVPADAWTDSLHQDGTATGTAHVAELTGLNPRLAGWTGTLRLLVRRTRPSARHARNLTALEKRTGWRYQIVATNITRIAGVPGSHQPQWLDALHRAHAGVEDHVRHGKATGLRNLPSKDWTVNQGWTLTCNIAADLAAWTRLLGLYDQPDLAHAEPDTLRYRLLHLPARLATHARRRVLSIPGTWPWADAFTLCWRRLTLLPPAT
>NZ_CP022961|4314164:4380006|4338597_4339032_-|WP_095565907.1|DBSCAN-SWA
MSYIVSWDGPSAEEPDRGNEVPVSTAQELDLVLDRVNAQAAAENLPYAVQIHQPGRHGAIMIGIGHPERSFVDWLDRSQPHGSGNRYATDPDLPPVSEAIAFDFYGDWTEMPPERTRISPERAREAAREYLHTGQQPSLAWVAG
>NZ_CP022961|4314164:4380006|4341163_4342558_+|WP_157756851.1|DBSCAN-SWA
MPLSGLGSADSTLVRRGHLTGLRSCDRMPKRSVQQRAGFRGEAFVDKAVSDAGHVWNDTRRDFAIDGQIEFVDTDREVTGVAVLAQVKATEVGFSGDSATGFAFRCEADHIAYWTRLGRPVVLICVDLRVDQAWWKRVDTWFADPERRARRVVRFDKIADRFDPDSFSKLSALGVPIGEPLPRLEGSERLVSNLLVIDRFASKIYEASTPCRDRGDAWERMRANGNQFEGGFLLSGGKIYSMCPLDHGPLAVLCDGPVSAIPTEAWSGTDDPALQRRFVSLLNFTLRSAYHPDLVWHPRKSVVYMQAPPDRSNRKIKGRYRGAKGRSFFTPYRGKDDDTKTMFCRHYAAGLYFRRWGGTWYLEINPTYHFTIDGRRESLFDAEYVKKIKRLEHNNAVYQLVRAWADYLQGEDTLFRTRDERIRFGRLLELDCDAAIDETVWIPQEPAPTSGTAGLAQGLWELPS
>NZ_CP022961|4314164:4380006|4320609_4320948_-|WP_157756847.1|DBSCAN-SWA
MLDDLVVADVPTMRVAELRDAIERLLAAIEVRFGEEIRFTGDFYWSVGLTESFDLVSESVASVDVASLVDDVASIREIVGQAVDEPVVLWHDLTHLAGLLRGIARLDTERPG
>NZ_CP022961|4314164:4380006|4334957_4335788_-|WP_095565905.1|DBSCAN-SWA
MDDISKHLRDGQIGDVNSAVEQVEELVVILRHHGRDGVEPGAIPTLQNELRKAVKTCMEHLHTALTTLEHTKEHGSPRQAAKSLSKEAVEDVMLYLDLLGQLYAATAQLELAQIALYYHEGKVDVARTRAKLTTSSAGRVRTEIEDVLSRVDHLDESIRALFQPERWNRLPSAAAAAPAIAYAARKLAGAKVIRIAGLPIPVPPTAIAAVASALPTVVVSANAWLQYSAEKELDKRLMQLKQASSRSSRSLEQATESLEVLRTLPEELAGPGEPVH
>NZ_CP022961|4314164:4380006|4329809_4330094_+|WP_095567948.1|DBSCAN-SWA
MLLTFDVGVTERHHVTFSFNKFWGNLSIKVDDVSVVRTVRLASIDLVKRYEFTVGTEEQHHVRIEKHRERLFAGFRPQPVYAYVDDQLIAQGVA
>NZ_CP022961|4314164:4380006|4374500_4375928_-|WP_095565924.1|DBSCAN-SWA
MSAGELRTVRTNDPNWNTNGLQIVVRTEDDQPIELTRRLGAGGQGEVWEAAGGRIAVKVLHSRDQQAAERLAARLRVVRQLDLDHLPLARPLTLLKPPHLGYTMAMLADMVALRQLVAPSGATEVLRWYTRTGGLRRRLRLLGRAAAGLSGLHARGLCYGDPSPVNVMVSAHLDREHVYLIDLDNIAVMSEVRGSAYVTPGYAAPEVLTGRLGVSSLSDAFAFGVMAFETLAVLHPFIGDLVYDGEPELEERAFAGELPWVDHPTDPANRASFGHARDLVLTPGLRALAARTFEAGLADPAARPTVGEWRTKLYEAADMTLTCAGCSGSYLGNQPACPWCSDPAPPALVARVFTQVPAQGGGAPVTGPPTQALLVQQQIQTAVSARIAMASDGDAERGVATLWFDRSGRLTVANRGDRPIWVVGPGGGPCLPVEPGHDSAIPGMASHAAWELHFGPAHEAHRLLRFDHLVRERSA
>NZ_CP022961|4314164:4380006|4321972_4322767_+|WP_095565900.1|DBSCAN-SWA
MAAVQPRTLAELTDLVATGKRAKYLYFWGHQAPRGGGIGAACLSQWWSARFTIDGRTFATAEHYMMWAKATLFGDTTTADQILTAPHPHKAKTLGRQVRRFGQPSWETHRYAIVVDANLAEFSQHPDLRAYLLGTGTRILVEASPVDRIWGIGLAATRRAGYRGTSRRSPWGLRDASGRLRCRSPKCRSDQRLHWVWRAERPYETATGRGRRSIVKGELQVRALLDEFFQRVADIGLEALRIDLRPIEVVSAHHVQVVLVPPVD
>NZ_CP022961|4314164:4380006|4363100_4364123_-|WP_095565919.1|integrase|DBSCAN-SWA
MLAHLGVTLADLQAEPGPGLPTLAEYLPQVIAAAGPGAHRTYGTYWRRMAAAWGDRPLDAVAASDIEAMQREIAATARSRRNSRNGRHAGEHVIAAARAIYNRAIADRLIDATASPAHRVLKPRRLPSTRRALTPDELEEINLAARTSGNDLILDSLVLRLHTETACRRGGALGLRLTDLDTSRGLVRLTEKGATLRWQPITLDLATHLNEHARARGAVLPTDRLLRYRNGRPITSRRYDHLWKRIGAQLPWVAAQAISTHWLRHTTLTWVERHYGYGIARAYAGHTDSTGPATTTYIKADLQAVATALAAMTGQPHPLAITPNRCRLQDRTAERSEPEP
>NZ_CP022961|4314164:4380006|4352661_4355553_+|WP_095565915.1|DBSCAN-SWA
MTAATQQTRPVFPVGSLVTARGREWVVLPGSDTDFLVLRPLAGGDDDVAGVFIDEGVTHATFTTPNPDDLGDDRSARLLRDALRIGFRASGGPFRSLAGLAVDPRPYQLVPLLLALRQETTRLLIADDVGIGKTVEASLVAAELLAQGSAQRLTVLCPPSLAEQWQTELQAKFGIQAEPVLPGTVRRLERGLEYGQSIFERYPFTIVSTDYIKSDMRRDDFLRAAPELVIVDEAHACVSDETGAGGRGRTQRHRLLKDLAADTERHLILVTATPHSGKEETFRNLIGLLNTSLRDTNLATEAGRRRLATHLVQRRRADIRDYLGADTKFPSDRATDERTYQLSPAYRGLLDDVLAYVQGQITDRSGSRVQQRVRWWSALSLLRSLASSPAAAAATLATRAASAGAASEQAADTAGAAGVLDLVDDDALDTADAVPGALFEDECAMSGSDAARLHELRRRALAIAQEPDAKQRTAHDTKLALVTTTVQRLLKDGFHPIVFCRFIPTAHYLADHLAAAFPKAVVEVVTGELPPEDRAARVRDLAERAGTTNKILVATDCLSEGVNLQHDFQAVVHYDLAWNPTRHEQREGRVDRFGQPRDVVRAVTLYGSDNVIDRIVMDVLIRKHEAIRRDLGISVPVPATSDQVLTALMDGVMKRGSTYVQETLDIGLPEQAQQLEFDWQSTAEAERRSRSRYAHHTIRPDEVRREVEAMRTALGSPDDVAGFVATALQECGGILTNEPYGFTVEAVGLPVGLRDAIGNPTKPLAFHRDLPAPRGAAVLARTDATSASVARYVLDAALDPALPTAARPARRCGVIVTNAVTTATVLLLTRVRANLTLPGRYGPHAQVAEEARPLAFTGTPANPQWLETDAVEALLAAQPDRNLSADIARNIMKGVLGAMPAITSHLDRFAHELAESLRDAHVRVRTAARGDRAGALGIRGLTVEPQLPVDVLGVYLYRPAAQA
>NZ_CP022961|4314164:4380006|4346550_4347216_+|WP_095565914.1|DBSCAN-SWA
MDPWAEAVNDYEVTVEPGAAGEADLLDSDNDWWLVACMDWPRDRWIGYVQGYWKAATVIVERVASTGRDQDYLVYPFLMCWRHYVELQLKTLILLAATYLHKPCDLPKTHKIDHLWRVARPLIEHSYPGEPTTDLDNIERILLQLHSFDPTSEHFRYPILKNGSATLTSLGRVHMRRFHLAMESVAGLLDGAETGIRVLIDQRNEYEAAMYDLYGSPDGSH

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095565896.1|4314164_4314986_+|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_157756846.1|4315956_4316370_-	hypothetical protein	NA	NA	NA	NA
WP_095565897.1|4316385_4316739_-	ADP-ribosylation/crystallin J1	NA	NA	NA	NA
WP_095565898.1|4320107_4320593_+	barstar family protein	NA	NA	NA	NA
WP_157756847.1|4320609_4320948_-	hypothetical protein	NA	NA	NA	NA
WP_095567947.1|4321349_4321907_+	hypothetical protein	NA	NA	NA	NA
WP_095565900.1|4321972_4322767_+	NADAR family protein	A0A1S6UAJ7	Serratia_phage	3.2e-23	44.3
WP_095565896.1|4323758_4324580_-|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_095567532.1|4325187_4326273_-|transposase	IS110 family transposase	NA	NA	NA	NA
WP_095565901.1|4327004_4327979_+	hypothetical protein	NA	NA	NA	NA
WP_095565903.1|4328271_4329228_+	MFS transporter	NA	NA	NA	NA
WP_095567948.1|4329809_4330094_+	hypothetical protein	NA	NA	NA	NA
WP_095565904.1|4330282_4331782_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	1.1e-45	29.8
WP_095565905.1|4334957_4335788_-	hypothetical protein	NA	NA	NA	NA
WP_095567477.1|4335968_4337366_-|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	3.7e-67	37.9
WP_157756848.1|4337488_4337971_-	hypothetical protein	NA	NA	NA	NA
WP_095565907.1|4338597_4339032_-	hypothetical protein	NA	NA	NA	NA
WP_157756849.1|4339028_4339826_-	hypothetical protein	NA	NA	NA	NA
WP_157756850.1|4339892_4340963_-	hypothetical protein	NA	NA	NA	NA
WP_157756851.1|4341163_4342558_+	DUF4365 domain-containing protein	NA	NA	NA	NA
WP_157756852.1|4342554_4344009_+	hypothetical protein	NA	NA	NA	NA
WP_095565913.1|4344230_4345403_+	hypothetical protein	NA	NA	NA	NA
WP_095565914.1|4346550_4347216_+	hypothetical protein	NA	NA	NA	NA
WP_095565915.1|4352661_4355553_+	DEAD/DEAH box helicase	A0A1B1IUI1	uncultured_Mediterranean_phage	1.1e-25	24.0
WP_095565916.1|4355549_4359647_+	N-6 DNA methylase	A0A1B1IUC6	uncultured_Mediterranean_phage	2.1e-46	27.6
WP_095565917.1|4359643_4361899_+	AAA domain-containing protein	K4I1H4	Acidithiobacillus_phage	1.6e-24	31.0
4361617:4361633	attL	NA	NA	NA	NA
WP_095565918.1|4361895_4363095_+	restriction endonuclease	NA	NA	NA	NA
WP_095565919.1|4363100_4364123_-|integrase	site-specific integrase	NA	NA	NA	NA
WP_157756853.1|4364151_4364295_-	hypothetical protein	NA	NA	NA	NA
WP_095565920.1|4365007_4367095_-	hypothetical protein	NA	NA	NA	NA
WP_095565921.1|4367094_4369401_-	AAA domain-containing protein	NA	NA	NA	NA
4368096:4368112	attR	NA	NA	NA	NA
WP_095565922.1|4369433_4371014_-	hypothetical protein	NA	NA	NA	NA
WP_095565923.1|4370994_4374504_-	AAA family ATPase	NA	NA	NA	NA
WP_095565924.1|4374500_4375928_-	protein kinase	NA	NA	NA	NA
WP_095565925.1|4375930_4376563_-	VWA domain-containing protein	NA	NA	NA	NA
WP_095565926.1|4378835_4379246_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_157757014.1|4379277_4380006_-|transposase	IS630 family transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_CP022961|5424797:5494945|DBSCAN-SWA
GTCACATCCGCTCGGGGGCCGAAACCCCGAGCAGGTCCAGTCCGTTGGCCAGTACCACCCGGGTCGCCTCGACCAGCCAGAGCCGGGCGCGGGTGAGGTCGGTCGCCGGTTCGTCGCCCTGGGGCAGCACCCGGCAGGCATCGTAGAACCGGTGGTAGTCGCCGGCGAGCTGTTCGAGATACCGGGCCACCCGGTGCGGCTCGCGCAGCTCGGCGGCGGTCGCCACCACCGCGGGGAACTCGCCCAGCTTCTTCAGCAGGGTGTTCTCCTTCTCATGCCGCAGCAGCCCCGGGTCGAACTCCGACCCCCGGTCGATGCGCAGCTCACCGGCGTTCCGCAGCAGCGAGGAGATCCGGGCGTGCGCGTACTGCACGTAGAAGACCGGATTGTCGTTCGAGCGCCGGGTGATCTCCTCGATGTCGAGGGTGAGCGGCGAGTCGGTGGAGGACCGGGCCAGGGAGTACCGGGCCGCGTCGACGCCCACCGCCTCGACGATCTCGTCCAGCGTGATGATGTTGCCCGCCCGCTTGGACAGCCGGACCGGCACCCCGGCCCGGACGAGGTTGACCAACTGCCCGATCAGGATCTCGATGTTGTAGTCCGGGTCGTCGCCGGCGCAGGCGGCGATCGCCCTCAGCCGGTTGACGTAGCCGTGGTGGTCGGCACCGAGCAGGTAGACGCACTTGTCGAAGCCGCGCTCCCGCTTGTTGATGTAGTACGCCGCGTCGGCCGCGAAGTAGGTCTTCTCGCCGTTGGACCGGATCAGCACCCGGTCCTTGTCGTCGGTGAAGTCCGTCGTGCGCAGCCAGATCGCGCCGTCCCGCTCGTACACGTGGCCCTGCGCGCGCAGCTCGTCCAGGGCGTGCTCCACGGCGCCGCTCTCGTGCAGGGTGCGCTCGGAGAACCAGACGTCGAAGTGCACGCCGAAGCGTTCCAGGCTGGCCCGCATCTCGTCGAGCATCAGCCGGTAGCCCTCGTCCCGGAAGACCGTCTGCGCCTGCTCCGGCGCAAGGTCGAGGACGTCCGGGCGGGCCTCGACGAGCCGCCGGGCGATCTGCGCGACGTACTCGCCGACGTACCCGTCCTCGGGAACCGGCTCGCCGTGGGCCGCCGCGTAGAGCGACCGGCCGAACCGGTCGACCTGCGCGCCGGCGTCGTTGACGTAGTGCTCGCTGGTCACCTCGGCGCCCGCGGCGGCCAGGATGCGCCGCTGCGAGTCGCCGACCGCGGCCCAGCGGGTGTGCCCCAGGTGCACCGGCCCGGTCGGGTTGGCCGAGACGAACTCCAGGTTGACCCGCTGGCCGGCCAGCCGCGTGCTGCGCCCGTACCCGGAACCGGCCTCGACGATCTCCCGGGCGAGCTGCCCGGCGGCGCTGGCCTCGATCCGGATGTTCAGGAAGCCCGGTCCGGCGATCTCCACGGACTTGATCCCCGGCGCCCGGCCCAGCTCCTCGGCCAGCGCCCCGGCCAGCTCGCGCGGCGCCACCCCGGCCCGTTTGCCGAGCTGAAGGGCCAGCGTGGAGGCGTAGTCGCCGTGCTCGGGGTTGCGCGGTCGCTCGACGGTGGCGGTGGCGGGCAGCAGCGAGTGATCGAGGCCACGCGTGGTGAACACCGCACGTGCGGCGTCGAGGACGACCTGGGCGAGCTTGGCGGGAGTCACTGAAACATGCTAGCCGGGGTAGACTCGGCGCCCCGGCGGCGACCCTGAGCTAGACGTGGACCCGGTAACCGCCTCCCCCGCGATCCACCGACCTGACGAGGCACGATGAGCATCAGCACCCCCGGTGGCGATCCACGCCGGCCGATCGTGGTCACCCGCAAGAAGGCGGTGGCCGGCGGCAAGCCCGCGACCGACGACGAGCCGGCCACCCCGGTCGAGGACGGTGAGAGCGGCCCGGACGCCGCCGCCGACGAGGCCGGTTCGGGCGCCGCGACCAGCGCGGACGCCAAGTCCGCGAAGCCGTCGAAGCCGGTCCCCGGCGCCCGCCCGGCGCCCGGGGCCAAGAGCGCGGCCAACCGCGCCGGCCAGTCCCGGCCCGGCGGCAAGCGGCCCACCGACGGCAAGCGGCCGACCGGTGGTTCCCGGCCGGCCGGCGGCGGCAAGGGCCGCAAGCCGATCGCGCCGGTCAAGGTCAGCCAGGGCCGGGCGTGGGGTCCGATCGCGCTGGGCACGGCCGTCGGGGTGCTCGCGGTCGCCATCGTCGGGTACGGCGCCTGGGCGGTCTACCAGGGTGGCCGGTCGTGGCAGGACAAGGCCGACTCGATCTCCGGCATCCTCGACGTGCGCAAGACCGACCCGGAGAGCCTGAAGTACGAGAAGCACCAGGCCGGCCCGATCAACTACACGAAGTACCAGCCGCCGGTCGGCGGGGTGCACAACGACGTCTGGCAGAACTGCATGGGCGACGTCTACGACGCGCCGATCGCCAGCGAGCACGCGGTGCACAGCCTGGAACACGGCGCGGTGTGGATCACGTACCGGCCGGACCTGCCACAGGACCAGGTCGACAAGCTCGCCGAGAAGGTGCGCGGCCAGTCGTACATGCTGATGAGCCCGTACGAGGGCCTGGACAAGCCGATCTCGCTCCAGGCGTGGGGCTTCCAGCTCAAGGTCGACAAGGCCGGCGACGGCCGGATCGACGACTTCATCAAGGCGCTGCGGGTGAACGCCGCGGCCGAGCCCGGCGCCTCCTGCTCGCAGGGCATCACCGCGACCGGCACCACCCCGCACGACCTGCCCGGCGGCGGCGACGCCAACGCCGGCGGGATGGGCGGGTAGGCACCGCAGCGGGGAGCCGAGCGATGACGATCTCCACCGATCCCGTGCTGCGGGACGACCTGGGCGGGCCGCCGGCGCCGCCGGCCGGAGCGCCGGCGGACCGCCGCTACGGCCTCCTGGCCCTGACGCTCGCCGTCGTGGTCGGGCTGCTCATCGGGTACGTCGGCGGCTGGCTGACGCCGCAGCTGGGCGCGCCCGGGGACAACTCGCCGGAGGCCGGCTTCGCCCGGGACATGTCCGTGCACCACGCGCAGGCCGTGGAGATGGGCATGATCGCGTTCCAGAGCGCGGCCACCCCGGGAGTACGGATCATGGGTGGGGACATCGCCACCGGCCAGCAGGCACAGATCGGGATCATGCAGACCTGGCTGAAGGAATGGCGGCTGGAGCCCACCGGCTCCGAGCCGGCGATGGCCTGGATGCCCGAAGGCGTCGCCGCGCTGCGGGACGGCCTGATGCCCGGGATGGCCACCCCGGAGCAGATGGCGCAACTGCGCGCCGCCCGGGGCACGCAGGTGGACGTCCTGTTCTGCGAGCTGATGATCACCCACCACCTCGGCGGGATCCACATGGTCGACGGCATCCTCGACCAGACCCACGACCGCCGGGTGGTGGAGATCGCCGAGGCGATGAAGGCCACCCAGCAGACGGACATCAACAACCTGACGGACCTGCTGGCCAAGGCGAAGGCCGGCTGACGGCACGGGGTTCACCGACCCTGCCCCTCTGGGCGGTCAGGCTTGATCCCGTCGTGGGCAAGGGCCGGCGAACCCTTCCCGTCAATGATCGAAATGTGTCCGGTTTGGTGGTTACTGACCGCATCTGCGGAGTGACAGCGTTTTTCTCCACAGATGGCGTACCGGCCCCGATCTGGGCTCGTTGTCCAGAGCATGACGGTTGTAGCGGTACGTGACGCGCGACGGTCGGTGGCCAGCTGGTGCCGGCGACACACGCTGGGCGGCGAGGGGGCCATCGCCGCGGCCCGACGCGGCAGCGAGCAGGTGGGCGAGTCCACCGTGCTCACCCGACGCCAGGAACTCGACCTGATCGCGCTCGTCCGCGACCGCTACCCCGAGGAGTTCGGGCTCGACGAGTCCGGGCCGGACGACGAGCTGTGGAGCCGGCACAGCCTCACCGAGGTGATCAACCGCCGGTTCCAGGTCTCCCTCGACCCGACCGACGTGGCCGGGTACCTGCTGGCCTGGGGGCTCGGCCCGCGCGAGGCCACCGACCGCGCCTGCGGCCTCTGCGTGGCCGAGGTGACCGACTGGATGGACCGGGAGTACCCGGCGATCGTGCGGACCGCCCGGGAACACCAGGCCGAGCTGTACTGGGTGGGGCGCACCCGGATCCACGGCGCCTCCCCCTCCGCCGACGTGCTGTCGGCGATCTCCACCCGCGGACGCACCCGGTTCCTGCTCACCGCGCCGTCGGTGGACCCGTCGCTGCCGCGCGAGTTCCTGCTCCGGCTCAGCGGCCGGGACGGCCGCACCGTGCACGCCGTGGTCGACGGCTCGTGGACCCGGGTGGAATGGCCCCGCCGGATTCCCGCCCGGATCGTGCTGCACCCGCTGCCGAGCTGCGGCCGCACGACATGACCGCGGCCCGCGGGTCCCGGACCGCCGCGCGGACCCGACGCCCGTACCCGGCCGCGCGGACCCGACGCCCGTACCCGGCCGCGCGGACCAGCCCCGGTGGACCCTGACCCGACCGGCCGGTCCATGCGCGAGCGGATGCTCGCCGGCGACCCGTACCGGGCCGACGACCCGGACCTGGTCGAACGCATGCTGCGCGCGGCCGAACTGACCGCGGCGTTCGGCGCGGTCCCGGCCCGCGACCTGCGGCAACGCCGGGCGCTGCTGGCCGACCTGCTCGGCGCGATCGGCGCCGACACACAGATCCGGCCACCGCTGCGGGTGGACTACGGCGACCAGATCCGGATCGGCGCCCGGGTCTTCGTCAACTTCGGCCTGGTCGCGTTGGACGCCGCGCCGATCACCATCGGCGACAGCGTGCAGATCGGACCCAACGTCCAACTCCTCACCGCGACGCACCCGGTGGATCCGCCGTCGCGCCGGGACGGCTGGGAGGCGGCACGGCCCATCGCCATCGGCGACAACGCCTGGCTCGGCGGCGGCGCGATCGTCCTCGCCGGGGTCACCATCGGCCACGACACCGTCGTCGGCGCGGGGGCCGTGGTCACCCGGGACCTTCCCGCCGGGGTCGTCGCGGTCGGCAACCCCGCCCGGATCATCCGGACCGGGCTGCCGGCACCGCAACGCCCGCCGGAGCGGTGACGGCGCCTCCTCCCCCGGACCGGCACGATCCCGACCGGCGCGATCCCGACCGGCACGATCCCGGACCCGTCGATGCCGGCCGCCGGCGGCGCCGTACCCGGGCACAATCCGCATGCGGCGGCGGCGCCGGCGCCGTACCGTCACCGCCCGTGCCCCGACTCGAGATCCGCCCCTTCACCGCCGACGACATCGACGCCGCCGGCACCCTGCTGGCCCGCCGGCACGCCCGGCACCTTGACCGGTCTCCGCTGCTACCGGCCCACTTCACCGAGCCGGCCGCCGCGACCGCGGCGGTCCACCGGGCGTGCGCCGGCCAGGACGCCTCCGGCTCGATCGCCACCCGCGGCGGCGAGGCCGTCGGCTACCTGCTCGGCGCGCCGAAGTCGACCGAGGTGTGGGGGCCGAACATCTGGGTGGAATCCGCAGGCCAGGCCACCATCGAGGCCGAGACCATCCGCGACCTGTACGCCGTGGCCGCGACCCGCTGGGTCGACGAGGGCCGCACCGCGCACTACGCCCTGGCACCGGCCACCGACCCGGAACTGATCGGGGCGTGGTTCCGGCTCGGCTTCGGCCACCAGCACACCCACGCGATCCGGCCGGTACCGGCGTCGCGGACGGACCCGCCCGCGACGTCGACCGCGACCGCGACCGCGACCGCGACCGCGACGACCGTACGCCGGGCCACCCGGGACGACATCGAAACGCTGGCCCGGCTCGACCTGGAACTGCCGCGCCACCAGGCGCTGGCACCGGTCTTCTCCGCCGGCCCGGTCCCCACGCTGGAAGAATGTCTCGACGACTGGGCCACCGACATCGACAATCCGGAGTACGCCGCCTTCGTGGCCGTCCGCGACGGCGAGGTCATCGGCTCGGCGATCGGGTGCCCGCTGGAAAAATCGTCGTCGCACACCGGACTGGCCCGACCCGAACGCGCCGGGTTCCTCGGCTTCGCGGCCGTCTTCCCGCAGGCCCGGGGAGCCGGCGCGGGCCGGGCACTGGGTGAGGCCGTCCTCGACTGGACCCGTACCGCCGGGTTCTCCTGCGCCGTCACCGACTGGCGCGCGACCAACCTGCTGTCGTCCCGGGCATGGCCGGCGCTCGGCTTCACCGACTCGTTCCTGCGCCTGCACCGCGTCGTCGGCTACTGATCCACTCCGCCCCCGGTGACCCGGACATCCCAGGTCACCGGGCCGGTCCGCCGACCCCACCGCGAAGCCGGGCCCGCTCGCCCGACCGGTACAGCGACCCGCCGGATACCGATTGGGCTCCCCGCGACAGGGCCTGCTACTCTTCTCGGGTCGCTGAGCCCCCGTAGCTCAGGGGATAGAGCACCGCCCTCCGGAGGCGGGGGCGCAGGTTCGAATCCTGCCGGGGGCACGTCGAACATGGGAACGACTTACAGGGGCGGACGCGCTGGCGTCCGCCCCTACTGGTTCATGTGTGGGCTGTCGTTGTCTCGGCACCGAACGGGTCGAGGCCGCTACCTCTGCTGCGGCCTGGCTGATGACGTCGACCATCTCTGAACGTACGGCTACCCGCAGCGTGATCCGCTGAAGGTGCCGGTCGTACCGGATCTCGAGCTGAAAGGCATCGAACAACTGCCGCTGCTTGTCGTCGGGTAGATCGAGCACGTTGAGATCGACATGGGGCAGCTGGTCCACCAGCTCGCGTGCTCCGGCTCCCCTGGGTCGGGTGGCCTTGGCCAGCTCCTGAAGCTCAGCGGCTAGGGTCTGCTTTCGCTTTGCGTTGTCGGCGAACTGCCGCTGAATCTCGGTTCGCCACTGTGCGTCGATCTCGGGGTCACCCGAACTTGCCATCTGCTGGAGCGACATGATCAAGTTCTTGTTGGCCGCATCCAATTCATCGATCTTGCGGGCGTAACTCGCGGCGGTCGCCTCCGCGTCGGAGCGGATCGGCTGCTCAGCCGGCCCCTCAAGGTAGTCGAGCCGGTGCAGCCCGAAGACCCGCTCGTTGAAGAACCGTGCGACGAAGGTGTCGATGACATCCTCGTTCACGGTCAGCGCCGGGGGATGGATTTCATACCACATCTCCTCTTTGTGGTGCTCGCGCTTGGTGACGCAGGCGTAGTAGGTGTCGTCGGCACGCGTCTTGCGTTTGCGGGTCTTACCGAACATACGTCGTGCACAGATGTCGCACTTGATATAGGAGCGGTACCGGTAGCTGCGCTTGGTTTCCGGGTGCGCATTGTTGGTGGCCTTCGACCGCGATCCCCGCCGGTATCGTCCCACGGGGCTGCCCGCATCGAAGTAGGCGCGAGTCGTGAGCGGCTCGTGCGTCACGCTCGGGGACCAGACCCATTCACTGGGCGGGTTGACCCGCCCCTTTACTCCTCGCTCGGGCCGCGACCGCTTACGCCGGTTCCAGACCATGTGCCCCACATACTTGGGGTTGTTGAGAATGTCGCGCACTGCCGTTGGGGTCCACGCTCCGATGGCGGTGTTGTAGGACTCCCGCTTGACCGGCACCGGCGGTGGGTAGCGGTCAAGGTCGGTGTTGAGCCGGTCGGCAATGTGCTGATACGACAGGCGCTCCAGCGCTCGCCAGACAAATATCTGGGTGACGACCGGTCCACGAGCCGGGTCTCTGACGAGCCGGTGTTTCGTGATGCCCTCCTCACGCTTGGCCTTCACCGGATGCGGATGCCGCTCCGCGAGGTAGCCGTAGGGCGGCTTCCCGATGTTCCAGCCCTGCGCGGTGTGCTGCATGAACCCCTTCCACGACAACTCCAGCATTTGAAGGACGTACCACTCTGAGATCGCCTGCTTGACCCGCCGGGTCAGGACAGAGGTGGCATTCTTCGGGCCGCCTGTTCCGCTGGGGCGGACCGCATCGCGATCGATGCCTTCGTCGGCAGCGAGGAGCACAACGCCGGCCTGTTCAAGTTCATGCTCGATCTTTGTTCCGTAATAGGTGGTCCGCGCGATGCGCTCTACGGACTCGCAGACGACAGCGACGAAGCGTCGATCGGGGCGCTGGGCCTCGGCAAGCAGGTCGGCGACGCTGCCGTCGCGGGGTACCGGGATGTCGAAGGCTTGGTACGCCTCGCTCTGGCCGCGTAGGTCCATTTGTGTGCGGAAGCGGTGCTGACCTATCTCCCGCTCGACCCCGCCAAGGTGGTCGAGCCGGCGATGCCAGCGCACCACCTCGCACACGCGTACAGCGCGTACGCGACGAGCCCATTCGCGAGCACCGACGTGCTCGTCGTTGACGAGCAGGGTTCTCGGTTGCCGGAGGGCCGTTATGAGCGATCCACCTGGTGCACCGGTGACAGCGGACCGCTCTGGGTTCGTCAGCGGTTCTTCGGCTCCGGTTCGTCGTTGAGCCTCGGCATGTTCTTCGACGTCGTCGCGGCGCTGGTCGGACTCTCCGAGGCTGGACTTCCGGCCGCTGGCAAGCTGATGGCACTTGCGGCGTATGGCCGGGATCGGCCCTGGCCCGATTTGGTTCAACGCCACCCCGACGGCGACACCGAGGTATCGCTAGCCGAGCTCGACCATTTCCTTGGCGAGGTGGCCAAGGTCCCGGTCAACCACGGCTACGATGACTGGCCGCCCAGCTCTATAGAGGACCTTCGGCTGAAGTACCGGGCGATCCGATGGTGGCTCTTCGAAGTTAAGCGGGGTTGAGGTGTCTGCGGTGGCGGCGGGTGGTGGCGGCGCGGGTGCGTAGCCGCTGGTTTTCGGGGTTACGGAATCCGTAGGCGTCGCGGGCGACGGTCTTGATGACCCGGTTGGTTCCTTCGGAGCCGGCGTTGGTGATGCCGGTGTGCAGGAACGCGAGGATTTCCGGCCACCAGGTCTCGATCGTGGTGGCGAGCCGGTGGAGTTCGGGCAGGTCAGAGTCGGCGCAGCGGGTGTAGAAGCGGTGCAGCAGCCGGGCGGTGGTTTCCCGGTTCGGGTGGGTGCGGGCGAGTGCGAGTAGGTCGAGCAGGTCTTCCTTGGCGTTCCAGGCCGTCAGGATCGGTGCGCCGATCTTCGCCGGCAGGTTGCTGAGGGTGTCGGTCAGCCGGTCGACGTGCTCGGCGCGCATGCGGGCTGCTGACCTGGTCAGCCGGTTGCGTTGCTGCCACTCCGGGTCGGTGGCCCGGCCGCGCCGGCCGCGGTGTGTGACTGTCATGCGGCGGCGGACCTCGGTGACGGCCCGGTTGGCCAGCTGGACGACGTGGAAGTGGTCCACGACCAGCGTCGCGTGCGGCAGCGCCTCGCGGACGGCGGTCTTGAACACGGTACACATGTCGATCGCGACGGCCTGGACGTGTTGACGCCAGGCGGCGGGGCGTTGGGTGAGCCAGTCGGTCACCGCCTTGCTGGTCCGGCCTTCGACCTGGGCGAGTAGACCCTGCCCGCCGACGAGATCGCAGAAGCCGACGTGCCAGCGGTCGACGATGGTGGTCCACGACGCGGTGACCTCGTCGAAGATCCAGCGAGGTTTGCCTCGGCGGACCTCGTCGATGCCCAGCACGCTCACCGGTTCGGGCTCGGCCGGCAGCACCGCTGCGGTGTGCGCGGTGAACGCGGCCGCGACGACTGGCCAGGACATGCCCAGATCACGGGCGGCCTGCACGATCGTTCGGTTGCCGTCGGCGACCGCCGCGCCGGCCGCCTGCCGCAACCGGACGGTGATCCGTGCCCGTGCCGGGATCTGTGGCACGTGTTCGGTGAACGACGTGCGCGGGCATCCGGGCTGATCGCAGTACCAGCGGCGTTTACGCCACCGCAACCGCGTGGTGCGTCCGGCCACCGGCAGATCCCGGGGCCAGGTGAACACCCAGCCCTTGACCCGGGCGGCCCGGACACCGCACTGAGGGCAGCATTGTGCCTGCTCGCTACCGGTGGACAGGTGGACGATGGGGGAACCATTCGGGTGCAGCTCGACCCGATCCACCACCAGGCCGTCCAGGCCCAGCAGCCGGGTCGTATCGTTGACCATGCTCGCAGCTCTTTACTTGTGATCATCCGAACTCGACACTCAGATGATCACCCAAGGGCTGCGAGCCCTCATCTCCGGGCCGGATCGATCAGCGCACCCCGCTCAACTTCGAAGAGCCCCGATGGTCCAGCGAGCTGGCCGCCGACCTGGCGCGCAAGGCACAGGGCGAGCTGGAACGGGCGATCCTGCACCAGGCCACAGCGCTGCGAGCTACGACCGGCGGAACCCATCTGAGCTATGCCGGCGGTGTCGCGCTAAACTGCACCGCCAACAGCCGTCTCCTCGAGACCGGCTACTCGGATGTCTTCATTCACCCAGCCGCCACCGATGACGGCTGCGCAGTCGGCCTCGCCGCGTACGGCCGGATTGAGGTGCTCGGTCATCCGCGTAGGCCTGTGCCGCGATTTTCGCCACGCCTTGGCCGCTCGTATGGCACAGGCGAGCGGCGAGCGGCGTTGAATCGCTACGGCCTCGGTCAGGTGAGCCGGCAGGTAACCCCAGCCGACATCGCCAACCTTATCGCCGGTGGATCGATCGTGTGCTGGTTCGACGGCGCGAGCGAATGGGGACCGCGAGCGCTCGGTGGGCGCAGCATCCTCGCCGACCCGTTGCGGGACGGCGTCGTCGTCGAGCTGAACCGGCGTGTGAAGTTCCGAGAACCGTTCCGCCCGTTCGGCTTGAGCGTCGCCGAGGACGCGCTGGCCGAGCTGATCGACATCGCCCAAGCGCCGGCGACGCTCGCGCCTTACATGCTGGCGGTCGGCCGAATCCGGGACGACCGCCTCAGCGCGATCGTGCACCGCGACGGCACCGTGCGGTACCAGTCGGTCACGTGCGACTACGGCCCTTACCACCAACTGCTCATGGCCTTGCGGAACCGGATTGGGCTGGCGGCCGTGCTCAACACGTCGTTCAACACCATGGGCGAACCTCTCGTCGAGACGCCGGACGACGCCGTACGCCAGTTCTTGCTGTGCGGCGCCGACGCGCTCTATCTCGACGGCGCGCTGGTCGAAGCCGATGACCTTCCGCTAGATACGCTTGCCGCCGCGCGCGAGCAAGCCTGGTCCGGCCGCGGCGTCGATCTCCTCCGCCTCGCATTGCAGCAGGAGGCGGCCGGGTATCCCGATGCAGCCCAAGAGACGGCGACGCGTTTGACGCCGTGCCGGTCCGACGGGCCGGGCCGGATCCGCGAGTCGGCCGCACTCATGATGCGCCTGGCCGAGCTAGCGGGCGCCGACGAAACTGCGGTGGAACGAGCCGAAGAAGTGCTGCAGTGGTCCGGGCTGCCGCCCGCCGCCGGCGACGCAGCGCGGCTGCTGACCGAAGTCTCCGCACAGGGGAGGGCCATCGGCCCGGACGCAGCCCGTTTCCTGGCCGCAATCGCGCCGCCGGGGCGAGCGTCCGCTATCGTCGCGCGGATGCTCTCATGACCTCGCTACCAGCGGATGTCTTGCTCGTGACCGGTCCGGACGAGGCCCGGCAAGTCCTTGATGACGACCGGACCTTCCGCGCCGCCCGAATGGAAGAGTACGTCCCTGGCGTCTCGCGCAGCTTCTTCCTGGCTACCGACGTCAGCGACCCCGAGAGCGGGGCACGCTGTCGCGAGGCACTAGCCGCGTTCCTCGCGCCCGATCGTCTGCGCGCGTTGCATCGCGACCTGATCGCCCCGGCAGCCGCTGGTCGAGTCGCGAAACTCGCCGCTGAGTTCCGAGCGACGCCGGACTATTTGCGGTCGTACGGACGGCAGGTGTCGTACGCGCTGGCTGGCATCGACGCTGCCGATGGACCGGCGATGGTCGCCAAGGTACGGCTGGCCGGTACACTGTTGGCCGAAGATCGGAGGAGCGCCGACGGGCGAGCTCTGATCAACGACGTCAAGCGGCAGTTGCGGTCGATGGCCTTACACTCGGGTTTCGCACCGGACGGGCTCCCGGGGCTCGCGCTGGCTCGGCGCCTGGCGACGGTGGACGAAGCGGTTCTGCTCGCCCTGCCGCTACTTGAGATGGCCGCCTTCGACATGAACACCTCCCTCGCCGCGGCCGCGCTGCGGCGGACCGCACAGCTGTCGCCGGCCGAGCAGCGGGAACTGCTCGATCCCGCTCAGCTGCGCCGGCTGGTGTGGGAGGCGGCCGCCGATCTGACCGACCTGCTGGCGACCCGGGTCGCCACTTGTCCCATGACAGTCGGCGCCACGCCAGTGGCGCCTGGCGACCGGGTAGTCGTGGACCTGCACGCTGCCAACCAGACCGGCCTCGACCACCTGTCCTTCGGACGCGGCCGCCACGCGTGTATGGGCCGCGAGTTGGCGATGACCATCGGCATCGCTCCGGTGAAGGCGATTCTGCGCCGGGGCTGGATCGCCGCCCAAACAGGAGGGGACCTAGTTGTGCGGATCCACCCCTGGGCTGCCTAGTCATGCCATCCGTTCCTGCCTTCCATGAGGATCGGCTCGACCGATCGGCGACGCTGACCTGGCGCTGGAACGGCACCGACTTCGGCACGCCGCAGCAATGGGGCCGCCAGTCCCGGCATCGGCGCGAATGGCGGCCCGGACAGGGCTGGTCGCTAAGCGCCGAGGAGGAAGCAGCGGGCCCGGCCGAACCGGAGTCGCAGGACATCACCGCAGCGCTATCGTCAGCCGTCCGACACCTCCATAAAGATGTATGCCTCGGGCTTCGGTCCACCACACGTCGATACCGGAACTCCGAGGGATCGAGTTCGACCATCGCACCGCTCGATGGGAACTGAGCTGGCGAAATGATCTAGGGCAGACGACGACGCGGGCGGCCGACTCCCTGCCCGACCTCGTCGCCTCCATCGACCGGAATCCGATCGTCGCCGCATCGAGCGAGCCGATGGACACCGTACGGGCGGGCGAACCAATTTTGCTCGCTCCCGGTGTGGCCGGCATTCTGCTTCATGAGCTGATCGGGCACGCGGCCGAGCAGGGCGATCTGTCCGTGGGGACACGGGTTCTTCCACCAGGAACGGATTTGCGCAGCCTGCCCGCTCGGCCGGATCTGGACGATGAAGGCGTGCCAGTGCAGGCCCACGATCTCGTCGTCGACGGCGAATATGCGATCCCCGTCCACGATCGCGCCTCCGGTGGGCCGCCGTCGGGGGACGCGTGGTGCGCCGCGCACGGTGTCGCACCCAAGGCACGCCTGATCCGTCTGACCGTGACCTCGTACATCCCGGGCCGGTCAACCTCGGACGGTCTCGTACATGTTCTGCGATCGACCGGCGGTGCGTATTTCCATGGGTTCGCCATGGTGAATGTGGCCCTCGCCCGGCGTGGTACGCGGCCGATCGCGGCTGTTCGTCTCGGGGTCAGCATCGCCGACCTGGCCCGTGGGCAATGGGGTCCTGCGGGCCAGGTGCAAATTGCCGACGGCGTCTGCGTGAAGGACGGCGAAGCGCTGCCGTCGATCATCGCCAGCCCGCCCCTGATTCTTGAGGGGGCATCTCTGTGGCCGGCGTGACGGACCACTACTGGCAACTGCTGAGCATTCGGTCGCAGACCTCATCTCGCGACCGCGGCCGGATCGGCCTATGCGCGGATCGGCTCACCGTCATTGCCGGCGGCCGACTCGGTTCCGCTGTCCGGCCGTGGCACGGCGAGCGTCGGCCGAGTATCGACGAGCTGTCCGAGGCGGCCATCCGCGCGGCGACCACCGGGCCGGCCGAGCAAGCCTTCGCTGCAGTAGCCGCCGACATGTCAGCTCTGCCCGAACGGTCCCGCCTGATGGCGTTCCCCTGGTTCGAGTACGCCGGTGACGACTATGAGAAAGTGGATTTTTCCGTACGCGACAGTCTCGGTGTGCGTGCGCACGAACACCGACACGAGCAGTGGGCTGAGTACTGCTTCGCCGGCCGACCGGTCGCCCGAGTCCCGAGTGGCGCCCCGGCGACCGCCGATCGTCCGCCGACCTGGGTGGCGGACAGCTGGCTGTGGTCTCCCTGGGCCCTGTCACAGGTTCTGCTGACACCACTGCTGGAGGCGGTTACCGGGCGGACGACCCTACGCAGGTGGCCGCAGTGCTCGCTTGCCGACCCCGCGTGGGGCGGGGGCGTTGACATGGAGGGACTCGCGCGTGCGCCGATATGCTTCGCCAGGGCCGGGCGGCCGGCAGCCATGGCCACCGACCGTACGTCCGCGTGGAGTCGTCGCGAGCCGCGAAGCGGGCACGCCGGACTGAGCGGGCCGGTTATACGTGACCTGGTCGTCGGTTCCGACGCGCCAGACTTGCCGCTGGCCCTAGAGGGTTCGATCGTGGTCGAAGCGAGATGCCTGGCCGCCGGGGCCCAAGGTGACCGTGCGGTGGTCGGGTTTCGCTCAACCGGACGTGACGGACTGCCCGGACCACCCCAGGCAGTCTCACTGGACTATCTGTCCGACCTGTTGGACGCCGGAACATGGTGCGGACCGTGGCAACGCGGCCTCGGACCGTGGACGTCGAGATGGCTTCACACCGTTGGAGGCACTTCATTATGGAATCGCCCGAGGCCACTGTAAGTGTGGCGGCCGGACCTGGGACGAGCCGACGGCGTCATTCTCCGATCCTGGCGGCGTTCGCAACGTCGGCGATCGGCGACGGCCTGCGGCTAGCGGCCCTTCCGCTACTGGCCGTCACGATCACCACCAACCCGGTGGCGATCGCCGGCCTAGCGGTCGCCGGTCGCCTTCCTTGGCTGCTCGTCGCGCTGCTGAGCGGAGTCGCGGCCGACCGCTACAACCGCATGAACCTCATGATCCTGGTGGACATCATGCGCGGCCTTGTCGTCTGCGGACTCGTCGTCTTCATCGTCACCGACGCTACCAGCATCGTCACGCTCTACGTGGTGGCACTCGCGCTCGGCGTCGGTGAAACGATCTTCGAGAGCGCCACTCAGGGACTCCTTCCGGAGGTGATCGACGGCAATCGGCTCCCCGCGGCCAACGGGCAGCTTTACATGGCCAATCTCTTCGGTACGACCTTCGCCGGACCGCCGCTCGGCAGCTGGCTGTTCGGGATCGGCCGTGCCATCCCATTCCTGACCGATGCGGCCACATTCCTCTTGTCCGCCGCTCTCCTTGGCGCCTACCGCCTCAAGCATGGATACAATCGGCGAGTCCAGGAACAGCCCGCCGACCGCGGATCGGTCCTGGTCGAGGTCGGCGAAGGGTTCCGGTGGATTCGCCGGCATCCTCTCATTCGTACATTTCTCGCGGTCTCGACCGTCGCCAACTTCACCCAGAGCCTGGTGCAGTCGTTGCTGGTCCTGCTGGCCACCCGGCACCTGGGGTTGTCGGAGTCTGCCTTCGGTCTGCTGCTTACCGCGAGCGGCGTTGGCGCTTTCCTCGGCGGCTCGCTTTCCGCTTGGGTTGGCATCCGACTCGGCGTCCATCGGGTCCTACTGCCCGCGGTGGCCCTATGTTTGCCCCTGTTTCTGGTGATGGCATGGACCGACAACTCGGTCGTGCTCGGGGCGGCGCTGGCCGTCAACGCGTTCCTCGGTGTCCTGGTCGGTGTTCAGATGTCGGCGCTACGGCAGCGGATCGTGCCAAACCAGGTCCTCGGCCGGGTCAGCTCGGTTAGCCAGTTCTTTTCGTTCGGCGTGGCGATCCCGGTGGGTGCCTTCCTGGCCGGCCTGATCGCCGATTGGTTCGGCATCGCCGCCGTCTACCTTTTCGCTGCCGCGGTCATCGTGGTACTGCTCGCCGCAGTCACCAACCAGCTCATGCCGGGCCGAGTCCGGCACGCGGTCGAAGCCTTGCAAGGAGCATGATTATGCACGGATTGGTAGCGCACGACGAGGGACACGTGCCAGTTGTGGACCTTGGAATCGCCGGCAGCCGGTCCCGTGCCCTTCTGGCGCAAACGGTCGCCGAGATCTGTGCGACGGCCGGTTTCTTCGTGGCGCTCGGGCACGGTGTGCTCACCGACGTTGTGGCGGCGATGGACGATGCGACGGCGGCGTTCTTTCACCAGCCGACCCGAGATAAGCTTGCGTTGCTGGCCGAGCCGGGTGACCCGCTGGCCCGCGGCCTCGGCCGGGACGGCAGTCTCGCTGGCCCCAACGTCAGCGCCTCGGCCATCGATCGGGCGGCCGACGACGTCCTCGAGACGTACACGATGAACCGGCTGGGCGAGCCGGAACACGCGGAGGACCTTCCAGCCCGCGTCGATCCGGTGATGCGGACCCCCAACAAATGGCCTGATCTGCCTGGCTTCCGGAGCGCCTATACCGCCTACTACGCGGCGATGGAACAGCTACAGATCTTGAATGGTCAGGTTCGTCCGATGTGGTCTGTGTGACGGCTTGGGGTTCGGGTAGATCGATGGGATGAGGTATCCCGATGGAGGTGGGTTGTCCGCGCGGGGGCGGGCGAAGCGTGAGGCGGTGCGGCGGGAGGCGGCCGGGTGGTTCGCCGAGGACGTGTCGGTGCCGGAGATCGCGCGCCGGTTGCGGGTGTCGCAGACGGCGGTGTACGGGTGGCGTAAGCGGTGGCGGGCCGGTGGTGAGCAGGCCCTCGCGTCGAGGGGCCTGGTGGGTCTCGGTGTCGGCTGGATGAGGGTCGGCTGCGGCGGCTGGCCGAAGCCCTGGAGCAGGGGCCGGCGGCGCACGGGTTCGGTAGTGATCAGCGGTGGACCCTGGCCCGGGTGTCGGACCTGATCGCCCGGATGTTCCGCACCCGGTACACGCTGCGCGGCACGGCGAACATCATGTACCGGTTGGGTTGGTCGGTGCAGGTACCGAAGCACCGCGCGGTCGAGCGGGATGAGGCCGCGATCATCACGTGGCGGCGGGAGACGTGGCCGGCGGGAAAACGGTAGCGGCGCAGCGGCAGGCGTGGCTGGTCTTCGAAGACGAGGCCGGTCAGACGCTGCGCCCACCGAAGGCACGCACCTGGGGACGACGCGGGCACACCCCTGTGGTTCCGGTGTCGGGCAAGGGCTCCGGTCGCGTCTCGATCGCCGGGCTGACCTGTTACCGGCCCGGCGAACGGTCCCGGCTGATCTACCGCACGATCACCCACCGCGGCCGCAAGAACGAACGACGCAGCTTCAGCGAACGCGACTACATCGCCCTCCTCGACGCCGCCCACCAGCAACTCGACGGGCCGATCGTGCTGATCTGGGACAACCTGAACACCCACATCAGCGCCGCCATGCGGCAGATGATCGACGCCCGGGACTGGCTTCACGTCATCCGGCTACCCGCCTACGCCCCGGACCTCAACCCCACCGAAGCCGTGTGGTCCCACCTCAAACGCAGCATCGGCAACCTCGCCGTCAACGGCGTCGACCACCTCCAAGCGATCATCAAACACCGACTCAAGAGCATCCAGTACCGCACCGACCTACTCGACGGCTTCCTCGCTCACACCGGCCTGACCCTCGAACCCGACACAACCTGACCATTCAAGATCTGTAGCGACCGCTTCGCGGCATGTTGGTATTCTCGATCTTGACGATCCGTCGAGGTCGCAGGAGCGGGCGGCTACTACCGGTCCGCCAACCGTTCTGCGCGAAATCGATCCGCCGCCGAGCAATAGTTCGCCTCCGACCAACGCGTCACCGCCGCTCTGCGCGCACGCCCGTGACCACCGGGGGCGGCGGCAGTTCTAGTCTCGCCGATGTGTCGGTGGACTATGCCAACATGACCACCATGGACATCTCAGTACAGCGCAGTGACGTTCAGGACGCCCCTTTCGATCCGAGCCTCTGGGCGCACGGCTTCCAACTTGGCTCGTCGGGTGGGATGGCCCGTGACCTCTGCGCGCGTCTCGTGCGGCAGGATCTTGGAAGCGCGAGGCACCACCTGGCGTGGCACGAACGAATTGAACGGACTGCTCTGTGACGGACGATCGGCCGTGAACAATCGCGAACTCGCGACCTTCATTCTTTTGGGAGCGGCAGCCGCCGCTTTCCTATGGAGTCGATCCGGCAGAGAAGCGTCGCCCTCGCTGGCGAGGCAGCTCTTCGCCTCAAGAATCACGCCTTTTCTTGTAGTGTTTGCAGGCATCGTGGTCGGTGTGACATGGCTTGCCGAGCGCCTATCGTTGTGGACAACTGACTTGTTGGGCTCTGTCGTCCTTTGGTTTTTGCTCGTCGGCTTCGTGTGGTTCATTAATCTTGGCGACGCCAACAAAGATCCAGATTTCTTCAAGCGTCGGTTTTTCGAGACTCTGGGCCTTACTGCGCTGCTTGAGTTCTTCATAAACGCGCAGGTGATGCCTCTGCCCCTCGAATTGGTTGCGCAGGTCATCTTACTGATCGTGGTCATCCTGAACGTTATTGCCGCAAGTGACGAAAAATACAAGCCGGCGGCAAAGCTCACGTCGGGCATCCTTTTCTTCGCAACCATGGGTCTACTGACCTACTCGGTGGCTCATCTAGTTTCCGGCTGGGATTCTCTTGACAAACGTGGTCTGCTTAACGAGTTGCTGATGCCCATCTGGTTGACGGCAGCTACCATCCCGGTCCTGTATCTTTTTGCGTTCTACATGGCATATGAGTCACTGTTCGTCCGGTTGTCGTTCTTCAACAACAGGCGGAAGCCTTCTCTGCGCGCGCGGCTCGGGATTGTTACAGGAATCCGAGGGGCGCTCGTCGACATCCAACAGTTCCGAGGAGGCCCGGCACACGACGCCGCCCAAGCCCGTACCACAAGTGATGCCCGTGCGGCAGTTCGTCGATTCAAGGAAGAACGTGCACTTGACCGAGCAGCGCGTGCTGCGGCCCGCCAAGCCTTGGTCGACAACGCTGGTCGAAAGGGGACCGACGGGGACGGTCTGCTCCTCGATCGCCGAGAGTTCGCTGAGACGAAGGATGCCCTGCGTTGGCTCGCGACTTGTCATATGGGTTGGTACCGCAACGCAGACCGGCCAGATGAGTATCGTGCTGATCTCCTGGATGTGCTGAGCGGGTCCCGGCAGTTCGAGTTCGAATCAGGCGAGCCCGTCGTTGCGAAGGTCCGCAAGGACCGGCAAGCTTGGTACGCCTACCGCCGAACGCCCTCTGGGCATGTATTCGGGATCGGCGCCTCCGGCCCACCACCTTCACAGTGGTTCTACGACGCCCCAACGCTCCCGAGCGGGTACCCGAGCACGACATCGATTGGCTGGACCGACTTTATGTCCCCGGATCGCCCCGAGTGGAGACTGGAGCCCGAGAGGTGACTGTTTTAAGGGTCGAGTCCGATGGCGAGCAATCCCGAAATGCGTCCTAGCAATGTGATGTCGTGCGTCGCCTGATGCGAGGCTTGGCCAAGCCGCAAGCCTGCCACGTCGCCCGATCCCGGCGCAACTCTTCTTGCTGAAGATCGGAGACGCCTAACATAGCCATGAGGAGATCTCGCAAGAGCTGGCGGGACATCGGCTCGTTGCTTTGCTTGGCACCGCTCCTCCACACGCACAACGGAGTCGGCCTTCCCGCGAGTCTTGGGGTTGTTCGGATAGGTTCGCAGCAAATCGATTGTCTCGGCGCTCGTACTGAGAGTGCCAGCCTGGATGGCGCTCCATATGTACAGGCACTTCATGACGGCCTCGCGATGCCCATCATTGAGAACGCCGAGTACGACCCGCGCAAGCAGATCGATCTCTTCTCGGCCCGGAGGTGCCACTTCACGATCTACAAGCCACTCCGCTGGGCGAAGCGGATAGGCTGGCCTCCCAGACCGAGCTGCCGCTCGGTACGTACGGCCCCGCGTCACCGGTAACGGCCAGGATCCCATCCAGACCTGGCCTCACGACACCTTCGTCCGCAGGAAAGACGATCCGCGTCGGCTGAACCGTGGCCATGATGAGTTGCCGAACGACCGCGGGCAACTCACCCTGCGCCGACCTACGCGCCGACCACTGATCCAAGTCAGTGCCGGTGAGCCTGAGACTCATTGGGCTCCCTGGCAGCCTCACGAACTACAGCGACATCATCCAATCTACCTGCAGCATGGCCCCCACATGCTTGAGCCTCGCTGTCGGACCCGCCGCCGAACCGGCCCGTCAGCCCACACCGCAGCGCGGGGAAGCTGAGGTCCGCGCAACCCGCCGGTTCGTGCGGTTGAGGACGCTGGCTTCGACGCGGCCGGCCCCATCACCTGGTGACCTGCCTGAGGCGAGTACAAGTCACCAGGTGACCATGAAGCACGCAGCAACGTTGACTGCCAGGCCTCCGGCCTCTACTTCGAAGGCAGGCTGTACCGGCAGGCGATCTCTACTGGATCGTCTTCGCAGCTCACCAATTGTCGCGGATGCTCGGGCCCCCTGCCCGGGGCACACAGAGCATCCGCGACAAACACCAGAATGAGCGCGTCTGGTTCTGTCCAGGGATCCGATGAACTCGGATGACGAGTTCGTGACGCCAGGCCACACTACACATCATGGGTGATCTGCTCAGCGCACTTCCCGGCGAGGGCTGGGACGACACCGCATGGATCGAGTACTACGACGGCGACCGCGGCCTAGCGGAAGGGTTTGCCAAGGCAGGGGACGCCATCCTCGTGGCTTGGCAGCGGGGTCCTCACCCGAACGACACGGTGCTCCTGCCTCTGATCTACAACTACCGCCATGGCATAGAACTCGCCCTAAAGCAGGCCATCCGCCAAGCGGCGGCTTGTATCTGCGTCGGCGGGAACGGCGAACCCGAACTGTGGGCCGATAATCTTGAAACTCATCTGAAGCGGAAGCATGGCCACAGGCTCGCGCCGTTGGCTACCCAGCTCCAGGGTCTGCTCACGAGGCTGAATCTTGGCGACCTTGGGGGCGAGAGTATGAAGGTGCTTTCGCGTATCCACCAGCTTGACCCGACGGGAGAAGCCTTCCGCTACTCGGGCCACTTGAACTCGACGGCTTACGCGGTCGATGTGAGCCGCCTCGCGGCGAGGTTCCGCGAGGCATTCGACATAATCCATGGTGGCGTGTTGACCATGCTGGACGTACACCAGGACTTCCTCTACGAGCGCTGGGAGTACGACAGAATGTGGGGGTGAACTAAGCGTCCTCATTCGAGCACGCCTACCAGCCATCCGGCCGCGGGGGGCGCGCCTTTGGGTGGTCCGCGCGCAGGGTTGCAGGTCTGGGACGGTTGCGGTTGGGAACAAGGGTCGTGGGTTCGAACCCCGCCGTCCCGGCATAAGCAAAGCCCTGACCAGCGTGATCGCTGGCCAGGGCTTCTGCGTTGGTCTACGTGTCCAGCTACTTCCGGTATCCGTCGCGGCGGACTTTCGCGTGGGTCGCGGTAACCGCCAGTTCCGGCCCCGCAATCACAGGTTGAGGGTTCGTATGCTGACAGGTTGGGTGCACAATCCAAACCTGCTCCCTTTGATCATCTGTTGTCCGTCCGGTGTGGCGGGAATCACTCGATCTGATGACTCGGTGTAATCCGCGGACCTGATTTGCTGCCCGCGGGTTGCCTCCGCCAGACGAGCCAGTTGTGCCAGCTCGGTGGTTGTCTTGGCGCTGATTTCGGCCTTGAAGGTCGCCCGGCCGGTCCGGCCGTCGTAGTGGATTTCGACGCGAAACGCCTCCAGGAACCGCCGAAGTCGCTCCGGCGGCAGCCGGTTGAGATCCACTCCGAGCTGTGGCAGGTGCTCGAGCAGGCCGGCGTCCTGCTCCTCCTCCGGTGGTGTCGCGGCCACGTGCTGTCGGAGCCGGGCCTCGGCCTGAGCGAACTCCTGTTCCAGCTCGGCCATCCTCCGTTGAGTTCGCTGGTACAGCTGGCCGTTAGGGTCGCTGGTGCGCTCCAGGACACGCATGATGGTTGGTCATGCTGCTGTCAAGGCCGGCGAGCTTCCGGCGGAGGACGGCCTCGGTTTCAAGGTGTTCGTCGCGGACGAGGTGGTTCGCCGCGGGCAGGCTGGCTTGCGCGAGCGCGAGCCGATCGGCCCGAGGACATGACGGTTGAAGAACAGCGTGACACCGTCGATCAGTCGGTCTTCCCTGACCCGGATGGCCGCGCGGTGATTTTCCGGCACGCGCACGGGCTCACCACGCGAGATGAGCGCCGTGTTGCCGGGGTCCTCGTTCAGCTTGCCGATGATCTGGCGAACGTAGTGTTCGGGATGTGGCACGGTGCGCCTCCAATACCGATGCCTGACCGTCTAGTCAGGAACGTATCGGCGGGGAGCTCCGCGCCCTATCCCTCGGGTTGACAGTCGTTCGGGCGGCGGCCGATCGCGACCGTGCAGTACCACTCGTCGGACGTCGAAGTGTGCGCCAGCAGCCCGTGGGCCGACATCGCCGCGGCCGTCAGTGCGGCCTGGCTCTCGCCGGTCTCGATGAGCAGGTGCCCGCCGGGTGCGAGCCATTGCCCGGCGTGCTCGGCGACGCGGCGGTGCACCTCGACGCCGTCGAAGCCGCCGTCCAGTGCCACCAGCGGTTCGTAGTCGCGGGCCTCCGGCGGCATCATCGCGATCTCGTCGGTGGGCACGTAGGGGGCGTTGACGATCAGGACGCCGACGGTGCCGCGCAGTTCGGCCGGGAGCGCGGCGAAGAGGTCGCCCTCGTAGACCCGGCCGCCGATCGGCTCGACGTTGCTGCGCGCGCACCGCACGGCGGCGGGCTCGATGTCGGCGGCGTAAAGCCCGATGCCGGGAACCCGGGACGCGACGGCCGCGCCGATCGCACCCGTGCCGCAGCACAGGTCGACGACGACCGCGCCCTCGGCGGTGACGGCGACCGCCTCCTCGACCAGGTAGGCGGTGCGCCGGCGGGGGACGAACACACCGGGGTCGACGGCGATGCGCAGGCCGCAGAACTCGGCCCAGCCGAGGATGACCTCCAGCGGTTCGCCGTCCACCCGGCGCTGGGTCATCACGTCAAGGTCGTCGGCCGTACGCGCGGCGTCGACGAGCAGCCGCGCCTCATCCTCGGCGAACACGCAGCCGGCGGCGCGCAGCCGCAGGACGACGGCCTCGGTGGGGTCGGTGGTGGTCATCGCGGGGCTCCCGTCGTCGTGCCGGTGGTGGCCAGGGCGGCGCGGACGGCCGGCACGACGTCGCTTCCGAGCAGTTCGACCGTACGCGCGACGTCGGCGAAGGGCAGGCTACCCGAGTCGACCTGCAGCAGCAGCCGGTCCCGGCCCAGCACCCGGTGTTGTTCCACGATCTTGGCGGCGACCTGTGCGGGGTCGCCGGCCAGCAGCGCCTCGGCGCCGGCGGCGTGCCGTTCGAAGCCGTCCCGGTCGAGCACTCGGGTGCGGGTCCCCGGCCGAGGCGGCTCCGGCGGCGGCGCAGTCGTCAACCAGCGACTGCGTCTCCAGATGGACGGCGCCGACCGAGTGCACCGGCCCGGTGCGTAGTCGTGACCGGTCGCCGTTCAGCGTGCCGAGGGCCGTGATCAGGCGCTCCGAGGCGGGCACCAGATCCTGCCCTGGCTGGTAGAGGGCGGAGACGCCGTCGCCGGTCACCGCGGAGGTCGCGGCCACCACGTCCCCGCTGCGCAACGTGGGATGGGTACCCCCGCAGTAGCCGACGCCGAGCACCGTGCGTACGCCCCGGCGGCTGGCCGCGTCGACCAGCATGGCGCACCCGGCCGCGCCGAGCACCGGCTTGGCGACACCGACCCGGGTGCCCTGGTATTCGTGGACCGCTACCACGCCGCTGCTGGCGCGGACCGGCCCCAGTGCGGCCCAGCCGCCCGCGTCGAACAGGTGCGGATTCTCCAAGGGTACGAGTAACACCTCGGGGAGCTCGATCTTTTCGTCGAAGAGCCAGCCGTCGACGATGTCGGCGATCCGGGTCTCCCAAGGGGTGGTCATCCGCGTGGCCCGGCCGGGCCAGTGTCGACGGCGGAGAGCTGACGCTCCACGTACCGCTCGAACCAGTACTGGCGGGACTCGCAGAAGAGGTCCCGGTGGTTGACGTCGCCATACTCGGCGTGGGTGTGTCCGGGTGAGCCGGAGCCGCAGAGGGCCACCCAGTCGCAGGACCGGCACTCGGGATAGCCTCCGGGCGGGCCCGGAAGGAGGCTACGCAGCGCCAACGTCGGACTGCGGGCTGGTGGCCAGGCGGTCGCCGCTCCGTCGGAGAAGGTGTTCTCGCAGCCGCCGGCGCAGGTGACCGACCGGTCCGGTGGCGCCGAGGCGGCGCAGGAAGTCCGGCACGCTCCAGGTTACGAGGGCGCCCTGGCGGGACAGGTACAGGCCGACCCGGTCAATGCTGTACCGGTCGTCGTAGTCCAGCAGCAGGTAGCTGGCGAGCTGGTAGATCTCGTCGCGACCCAGCCGGCGGGGTTGGATGGCCGCCTTGCAATCCAGCAGCAGGCCATCGAGGATGAAGTCGGCGTCCGCTCCGCCGATGTCCTGGCTGCCGACGAACGTCGGACCGCAGACCCGGGCGGTGGCGGGCAGTTCGAGGAAGGGCCCGAACGACTCCTCGGCGATCGCCAACTGCCGGTTGACGTCCTCGATGGCGTAGTCGGGGACCGCCGTCAGGAGATCGTCGAGAGTGGTGGCCGGGGTGGCGCCGGTCAGCATGCTGTACCGCCGGACCTCACCGGTCCGGTAGATGTCCTCGTAGTAGGCGGCCACGAAGCACAGGCGGCCCAGGATCTCCCCGTCGAGGTCGTCGTCGCCGTGCAGGTACGCATCGGCCATGGAAATCAGGTCGCGTCCGGCCCGGTGCAGGGCGTCCCGTACGGGTGGCGCGGGTGCACCCCGAAGGGGCAGGCCGCTGCCGACGGCGTCGACGCCGATGTCGACCGGCGCGCCGAACGGACTACCCAGGCAGAGTCTGAGCCGGAAGTCGATCGCGTGGCCGAGCGCCGACCAGTCGGGGTATTTCACGTCGAGTGGCTGCACCGGGCGGGGCAGCTCGCAGATCCGCCGGAGGTAGTCCTGCACGACAGCCGCGCTGTTCGGCAGGTGCTGGGCCACGAACTGCGACATCGGGGAGTTCGGATACCTCAGCTGGCGGGTCAGGCTCAGCTCGATCATCGGCCGCCCGGCCACCGTGCCGTCGCCGGCCGCCTCCGTGGCCTTCTCGTAGTCGTCGATCCAGTTGATCCCCGCCGGGTCGAGGTGGTGGCGGGCCCGGGTGACCGCCACATAGATCAGGCGGGCCTCACCGGCCCGTAGCGGGCGCGGCATCCCGTCGTCGTCGACCGACGGTGCCGCGAAGCCGTCGCCGATCCGTACCCGCGACCACTCCCGGCCCTTGGCCTTGTGCGCGGTGGACACGGTGACCTCCGCAGTGCGCTCCTCGGAGAGACGGTCGACCGCGTCGATGATCACGTCCGGCCCGTACGTGTCGACCAGCGTCACGATCGCCTTGAGGTCCTGACCGGCGGTGTCGTTCTCGGCGTACTCCTGCACGTCGGCCCACGAGGTGAACAGGAACAGCTCCGGATGACTGGTACGCCGACCGGACTTCAGAGCCTGGGCAGCCTGCGCGATGTTCCGCAACGCGCCACCGCCGCCCGTGAGCGCGACCGGTACACCCCGCTCCAGGAAGCCGAGGACCTCCTGCATCGCATCAGCGTTGCCCCGGCACAGCACGGCATCGATCTCCGCCGCCGACCCGACGCGGGAGTCGGTGGCACTGTTCCCGGTCAGTTGCAGATCCGACTCGGCGTGCCGGAGCCACCGGTTGGCCGTCCGGGCGATACGTGGGCCGAACCGAAACGACTTCGTCAGGTACAGGTGATCCGCCGGGAAGCCGGTCATCACGTCCCGGGCGTTGCGCCAGGCGTAGATCTGCTGGGCCGGGTCGCCGACACACACCCGCTGCGCGTTCTGGGCGAGGAAGACCTCCTCCAGGACCGGGTTGGTGTCCTGCGCCTCGTCGAGCAGGACGAAGTCCGCCGCCAGCGTGGGCTCGGTCAGCGCCCACATCTTCAGGTAGTGGTCGTGTTCGAAGCGCAGTTTGCCATCCGGTGAGCAGATATCGTCCCAGGCCCGGCACGCGTACGGCAGGAGCACGCGGGCGACGTGGTCCTGGGCCGCCGGATCCAGCCCGTTGACCGGTTCCAGATGCCGGGCCATCAGCTGGCGGTCGGTGCTGTAGCAGAACCGGCGGATCATGCCCATCACCAGGCGTGCCTGGTGTCCGCAGGTGATCGGACGGGAGCTGACCCACAGATTCTGGTGGATGCTCAGCAGCCGCGCGGTCTCCTTCGAAGGTATGCGGGCCGACCGGTTCAGACGCTCCTGGTAGTTCCGCCCGACGGCGCGGTGTGCCAGCGAGTGCGCGGTACGGCAGTCGACGTTCGCCCCGAAGCGCTGCCTGGCCTCGTCGGCGATTGCCTTGTTGAACGCCACGTAGAGACCGCGCTTTCTGGTGACCCCGGCCATCAGTACCAGCGTGGAGGTCTTACCGGTGCCGGCCCCGGCCACTAGGGCCAGTTCCCTGCCCGCGAGGAACGTGTCCCGGGCGGCGAGTTGTTCCTCGGTCGGCTTGACGTCCATACGCCCCTTCCAGGACCGATTCCCGTGCTCACACCGTCGTGATCCTTTGTAAACCTTCGGATTGCTCCGCCCCGGCCCGGAAGCTGCTCGCGGAACCAGTGGAGCCTACTTCGAAAGCGAGCACGGTGTGATCACTCCACTACCGCCATCCGAGCGATCCGCAGGCTCACCAGGCACTCGGTGGGCCAAGAATCTCGACGGCGATGCCGAGACACGTGCCCCACCCCGTCCTCGTGGTCAGCAGGGGCAGCTTCGACGCCTACAGGCCGCGCAGGATTCCCAGGTCAGCCAAACTCCCACACGTCTCACCCAGTCCAGGCAGTCCCGCAGTTAAGAGCCGGCGTCAAACACTGCTCTACTGCCCCGATAGTCCCACCAGTCCATATTCGGGTCAGTTTCGCCTGGTTGCACTGCACGAACATGCCCTATGGACCATGGAGAGCGAACCCTATCCACCCACGGTCGAGCACCCGCCGAGCACCCCGATGTCGCCCGCTCTGGAACTTCCAGCGATGAGGACCGACGCCGTTACATGCCAGTGACTGTCTTCTTGCTGCCCGAAGTCGCACAACGGCGGCGTGTGGAAAGTCCATCTATCCGGTGGCGCGACACCCCGTCCCGCCCATGCCAGCCCGGTCCAACGGCTCCCGAGCACCAAACGAGCAACCGACCACCGGCACGAAACCGAGAAAGGCCCTGACCCAGGATGAAACCCCAGGTCAGAGCCTTGCTGCTGGTGCGCCGCCACGGACTCAAACCCCGAACCCGCGGATTAAGAGCCAGCGTTGATCAATGCTCTCCCGTCCCTTCAGGTCTCACCAGTCCCACGCTCTGCCTAGCTTTGCCCGTTCATGCGACACCGATGTATCCCGCGGTCTACCCTGAGCGGAGCCTGTCCATGGCGACCGAGCACCCGGGGAGCACCAACATGACGGCGTCGAGCTCGATGATGCCTACTGCCGTGTTGGGGAGGAATCATCGGCGAGGCTCAGGCCCGACGTGACCCCGAGGGGTCAGGCCTCGGGGTAGCTGGGCACGACCGATGCAGCCGAGCTTTACCGCAGCACTCCGCGCAAGCCTCCGACCGGACGTCACGGCCTCGGCTCGCTGGTACCAGGCTTCGGGATGAACACCCGACGCGTCGGCAACGGTCGTTACCGCCCGTCCTTCGACTCGGCGGCCAACTCGTCGAGCAGCCGGGTGACCCCGTACTCCTCAACCTGGGCCAAGGTGGTCTTGTCGAGGCCCGGCGCGCCGTTGTTACGGCGCACCGCGACCCACGCCCGCCACAATACTCTGCGGAAGACCGCTGCGAGACAAGGAGTAGACCGCATGCTGCATGGCACGGACCGGATCCAGGATCGATCCACCAGCGGCGGGACTATTGTAGCCGATCGAGGACCCGGCGAGGCGGCCACTGTGCCGTTCAGCGATCGCGGAAAGGGCTCACCCGTACAGTAAACGTCATGGCTGACGGTGTGCGCCCTGTGATCGACAGTCTTGTGCAGCCTGAACACTTGATAGAAGGAGTTCAGGAGGCGAGCCACGATTTGCTCCAGCGCCTCGCCATCGCGACCGAAGTGTCCGGCGAACTCCAAGCCTACGCCCGCGAACTGGTCCAACATTTCGTTGAGCAAGCGCGCGAATCCGGCGCCTCATGGGCGCGGATCGGGCTCACCATGGGTATCAGCAAACAGGCGGCTCAGAAGCGGTTCTCATCAAACCGTCAACATTAGGTCGTCGAACAACACCCGCCACCGCTGGGCGTCTACCCTGTATCCGGCAGCCACCGCTGCGTCATGGTCAGTCCACACAACCGTCCATGATCGACGGTGGCTGCCCTCGTACCCCCACCGCAGGAACCGCAGCACAGCCGAGGTCAACATCCCCGGCTAAAGTACTAGGCTGCACCGGCCGTGTAGCTGCGCGTGTCGGAGCTATTCGGGCGAGGGATCAGGTGATCGCACTGTCTGTCTGTTGTTGTCGGTCGTGGTGCACGGCCCCGCCCGCGACAGCGCCCGCCCCCTGGCACTGCTCGGCATAACCTGACGACTTTGCCAGGCCCTGCCGGCGGCCGTCCACCGCCGCTAGGTCACAGCCAGCCTGCTCGTCCCGTCCCCCTCAACGCCTCGCCCGGTCTCCTTCGCAGGGCTTCCCGTGCGGAAGCCTCTTCCAGCGAACGTTCAGCGGACTGGCGCGGGCGCCGGTCTCATCGGGAATCGTCCCAGTCGCCGGTCCGCATGAAACGCTCCAAGCGCAGCGTGGGCTCGGTGAGGTCCCAGCGCTTTCCGGCGACCCACTCGTCGTCGTAGTAGGAGCGACGGTACGGCTCGGCACCATCGGCCGCCACGATGACCACCGCACCCGACTCGCCCGCCTGACTCATACGGTTCACCAGGTGACACGCGCCCCACAGACAGGCGCCGGTGGACGGTCCGGCCGCCACGCCGCCTGCCGTGGCGAGAAATCGCATGGCGGCCACGCTCGACACGTCCGGCACCGGGATGACCAGGTCGACGACGTCGGGATCGAAGGCCGGCTCCATCCGCGGCCGCCCGATGCCCTCGATGCGCGACGGCATTCCGGTCGCGTAGTCCCGGCACTCGGTGGCCCAGCCGGGGAAATACGCCGAGTTCTCCGCGTCGACGACCGCCAGCCGGGTGGCGTGCCCGTGCCGCCGCAGGTAGCGGCCGATCGCCCGGGAGGTGGCCCCGGTGCCGGCGCCGGTCACGATCCACGCGGGCTCCGGCCGGCCCTGGGCCGCGAAGTCGCGCAGGATCTCGTCGGGCAGGCCGGGCACGCCATCGTCGAGGTCTGCGTCGATGGCCGGCCCGAGCGTGGACAGGCAGTCCAGGTAGTACCCGTTCGACCGGCCGGCCAGCCGCTCGGCGTTCTCGTACACGGCCAGCGGCGGATCGACCCGATAGGCGGTCCCGCCCTGCGCGACGATCCGGGCGATGCGGTCCGGCGACGACTTGCCGGGCACGACCGCAGTGAACGGCAGCCCCAGCACCCGGGCGAAATGCGCCTCCGCGACCGCCATGTTCCCGCTGGTCGCCTCCACCAGCTGCACTCCCCGACGGATGACGCCGCGTGAGAGCGCGTGACGAAAGAGGCTGCGCGCGAAGCGGTATTTGACACTGCCGGTGGGGCGCGCCGACTCATCTTTCACAAACATCGCCGCCAAAGATTCACCGGGGAAGGATAAGCGAATCAGGGGCGTCGCTTTCTCAACGATACGGTCGGCTTCAAGAACAGCCGCAGCTCGGCGACTCCAATCATCTTCCGAGAACTCTGGAAGAAGTCCCGTCAACGCCATCTGAATCCCATCAGCGCTCGTGGCCAAAGGCTTCCGACAATTGCGCAAGGCGATCCCGGACCGAACTCACCAAAACGCCGCCGCTCGCTTTGTCCCGCCGCAGCTTGCCGCGCCTGACAAGATCATGGACGCCCTGCCGGGTGATGCCGAGCATCGCGCTCGCCACCGTCAGCGAGACCGCCTCGGCGGCCGGATGGCCGAACCGGCGCGCCACGAGCGCCCCGAACGGCGTGCGCCACCACTCGAACGGCGGCGCAAAGACATCGCCGGACTGGTAGATCTCGGCGACTAGGCGCCGGACGGTCTCGGCGGCGAGCCGCTCGTCCGGACCGAGCACCTGGGCCGCCCAGACCTCGGCGGCGATCTCCAACCGCCTGCGGAGCACCGAGGACACGGGCATGTCGTGGCGGTCCGTGCCCAGAAGCCGGTCCAGCGGATCGAGCAGGCGCGCCCCTACGTCGCACGCGAGCTGACGGACGATGGCCACGTGAACCGCGGTCGGCGCTGCGCCCCAAGCGGGCCCGCCGTCCACGAGACCGTTGCTACCTGCCGGTTCGCCGCCCATCCGTGCACCTCCGCCCCTCGCACCCATTCTAGCAGGCACTTGACACCAGCAGTAAAGCTGATAGACGTTTCAGACGCTAATTATCAACAACCGTTGCACCCCCACCCCACCCAAGGACTTGACAGACATCGTTAAGTGGGCGAGCATATTCGTCGGTGCCGATTTGCTACGGGGTAGCTCAATGGGTGTGGACGTTCGCCAAGACTTGTCGGCCAATCCCCACCACTCAAGCAGCGTTGAAACAATGCTCGCCGATGCTACGCTCCTCATCCAAAAAGCACTTGCCGTTCACGAAGGAACACGCCAGCCCTACTCATCGACAGCTGAGGCTGTGTATTCCGAGTCCGAAACCGCGGCCATCATGCACCACTACCTGGTGCGGCAGGCCGGCCGGTCACCCCACATCCGCTACATTGCCGGGTTCACCGCTGCCGGGCACGAGGTGTCCGCCGGTGCGCTGGAGCAGTCGCTGCTGCAGGAGTCCGCGTCCATGCAGGCGCTGATCGACGCCGACATGACCGCCCGACTGTCCGGCACCGACGAGTACTTCGAGCAGATGCTGGGCCACCACGTGCGGGCCCGCACCGTGAATCGGCGGCTGCCCCGGTTCGCCGTGCTGGACGGCGCGATGCTGCTCCTCCGCACCGACCACGCCAGCGTGCCTCGCTTCCTGATCGTCCGCGAGTCGCACCTGGTGCGCTCCATGGCGACGATCTTCGACGCGATGTTCGAGCGCGCGGTCGACCTGTCCGTCGCCGCCCGCTTCACCGGCCAGCCCGGTGAGGCGGACGACACCGAGAACCGGCTCATCCGCGTCCTGACCATGCTCGACGCCGGATACACCGACGAGACCGCCGCCCGTAAGCTCGGCGTCTCCGTCCGCACCTACCGCCGGTACGTCGCGGAGACCATGGCCCAGCTCGACGTCTCGTCCCGCTTCCAGGCCGGCGTTCGTGCCGCGACTCTCAACCTCATCCCGGCTCCCCGGTCCGTCCGGTACCACTGAGCGGTGCCGGTGCGGCCACCCGTGGACGGCGTGCCCGCAGCCGCACCGGCATCGACTCGTACCCCCTGATTAGGTTCGAGTGCAGCCGCACGGCCGGGCCGGCCGGCTCCGGTAGACACACTCGGTTGCAAAGCTCCTCGAACATCACGGTCAGCTCCATCTCGGCCAGCGCGGCGCCGAGGCAGTAGTGCTCGCCGGGTGCGAGCGCCAGGTGCCGGTTCGGTGACCGGCCGGCGTCGAACACGTCCGGCCGGTCGAAGGCTCCCGGGTCCCGGTTCGCCGCGGCCAGCCACACCGCGACGCGTTGGCCGGCCTCGATCCGCACCCCCTCGAGGTCCAGGTCCGCGGTGGCGACCCGGGCGACGTGCATGGCCGGGCTGGTGAATCGGAGGATCTCCCGCACCGCCGTGTCCATCGGCACCTTCCCGCCGGCCATCCGGGCCCACTCGTCCGGATGGGCCATCAGTGCCCGGACGCCGCCGACCGTGGCGTGCCGGCTGGTCTCGTTGCCGCCGGACACCAGGCCGTCGCAGTTCAGGTAGATCTCCTCGTCGGTGAGTGGCTCGCCGTCGACGCGACCGTTGACGAGAGCGGTTATCACGTCCTCGCCCGGCTCCCGGCGCCGCCGCTCGACCAGCTCGGCGTAATAGCACAGAATGTCCGTGTGGGCCTGTGCCATCGCGGCCGGGTCCGCGCCCCGGTTGCCGTGTCCGAACGCGGTCATGGTGCGGTCCAGCATGAAGTCCCAGTCCTTCGGCGGCACGCCCAGCAGGTCGCAGATCACCGACACCGGGAGCCGGGCCGCCACCCGGACGAGGTCGCAGGTCTCCCGCTCCAGCGCCTCGTCGAGCACGAACCGCACGGTCGCGCGCATCGTGTCGCGCAGCCGGGCGACCATGCGGGGCGTGAACGCGGCGTTCATCACGCGCCGCAGCTGGGCGTGCCGCGGCGGGTCCGTGACGATCAGCATGCGGTTCGCCGAGGACCGGACCGCGGCCGGGTTGTCGTCCAACCGCATGCCACCGGCGGAGGAGAACCGGGCGGCGTCACGGAGCACGGCCAGGGCGGCGGCGTGACCGAGGACCGCCCAGAACGGCTCCCCGTCCCGCCGGTCGATCCACTGCACCGGCCCGGCGGCCCGCATCCGGTCCCAGAGGCGCTCGGGCTCGCCGTCGCGGTAGAGGCCCGGATCGGCCAGGTCCCGCAGCCCGTACGTCACCGTGGTTCCGGGCTCTGCATGGACTCGGCCAGGCTCCGGGGCCGCATGTCGGTCCAGGACTGCTCGACGAAGTCCAGACACTCCTGGTGGGTTCCGGCCGCCCTGGCCACCGTCCAGCCCGCAGGCACCGCCGCGAATGACGGCCACAGGGAGTGCTGGTTCTCCTCGTTCACCAACACCAGGTACTCGCCGTCCGGGTCCTCGAACGGATTGGTCATCAGTTCCCCTCTCATAAGCGGTCACGCGGTCCCGGGCAGCCGGGGCCGCAACACGGCGCTGATCCGCGCCAGCTCGGCCGGGCGGGTCATCCGCCCGTGCGTCGTGTCCACCTCGTGGATCTCGATCCCACCGCTCACGTACGGCTGCCAGGCACGCGGATCCGGCGGTGGACCGGACCACCCGCGAGTCGCGCGGAAGAACAGCAGGTCCCCGTCGAAGACCGGCGGCCGGTACGCGCGCGCGGCCGTCGACGCGGCCGGCAGGATGCGGGCGACCGCCTCGACGTGCGCCTCGCTGAGGTCCGCGACACCGGCGGCACGCAGCAGCGCGGTGGCCGCCGCCGTGTCGAGCACCGCGCCGGTCGGCGGTTCCACGCCGAAGTACTCGCGTAGCACCAGGCGCAGGATCTCCGGCCGGTCGAGCGCCGGGGTCTCCGGAAGGGTTTCCGGCGGATAGGAGTCCAGCATGACGAGCAGGCCGGGCCTTGCCCCCTCGGCCTGGAGGCGGGCCGCGGCCGCGTGCGCCAGCTGGCCGCCGAGCGACCATCCGAGCAGCGAGTACGGTCCGGGCGCGCCCATCGCCCGGATTCGGCGAACGTACTCGGTGACCATCTCGTCGGCGCTGTCGGCGACCCGCGCCGGATCGGTCAGCCCGCGCGCCTGCAATCCGAAGAGCGGCTGGTCCGCCGGCAGCTGTCGCAGCAGGCCGGTGTAGCACCAGCTGAACCCACCAGCCGGGTGGAAGCAGAACAACGGCGGACGGCCGGAGACGTCCCGCAACGGCAGGAGAACGTCGAGCGGGTCGCGGCCGGTGTCGCCCAGGCGGGCGGCGAGCCCCGCCGGGGTCGGCGTCTCGAACAGGCTGCGCAGCGTTACCTCGGTGCCCAGCGCGGACCGGATGCGCGCGATCAGCCGGGTGGCCAGCAGCGAGTGGCCGCCCAGGCCGAAGAAGTCGTCGGCCGGTCCCACCGCCGGGAGGCCGAGGACCTCCTCGAACAGCTCGCAGAGGACTTGTTCGCGCGGTCCGGCCGGCGCGGAGACCCCGGTCGTCCCCGGGCCCGGGTCCGGCAGCCCGCGCCGGTCGACCTTGCCGTTCGGCGTGCGGGGCAGCCGGTCGAGCACGACCAGCACGCTCGGCACCAGCGCCGGGGGCAACAGCGTGGCGACGTACCGCCGAAGATCAGCCGGGTCCGGCACTGCGCCGGGGGCCGGCGTCACGTAGCCGACCAGCACCGGGTCACCGCCGGGTGGCCGCCGGACCGCGACGGCGGCGGCCGCGGTCGTCGGATGCCGGGCGAGCGCAGCCTCCACCTCGCCCGGTTCGATACGCACGCCGCGTACTTTGAGCTGGCCGTCCGACCGTCCGAGATGGATGAGCTTGCCGTCCTGTCGACAGGCCACCCGGTCGCCGGTCCGGAACATCCGGGCTCCCGGCGGGCCGAAAGGGTCCGCGACGAACCGTTCCGCGGTCGCGCCCGGCCGCCGCACGTAACCGCGCCCGACCCCCGCACCGCCGTAGTAGAGGTCCCCCGCCACCCCGGTGCGGACCGGGCGCAGCGCGCCGTCCAGCACGTACGCGCGGTTGTTCCACAGCGGGGTACCGATGGCCCGGTCGTGCACGTCGCAGAGTGCGAACACGCTCTCGCTGCTCACCTCCGTGCACCCGCAGAAGTTGACCAGGCGGGCGTCCGGGCTCTCCACCAGCAGCCGCGCGGGCAGCTCGGCCGGCATCGGCTCACCGCTGCTGAGCACCAGGCGCAGCGACGACAGCCGGCCGGGCGGGCCGGCGGCTGCTTCGTCGAGCAGGGCCAGCAGCAGGCTGGGTACGGCCGTCAGCACCCGAACGTCGTGCCGGGCGACGAGATCGGCCAGCGCGGTCATGTCGGCGGCAGCGGCGTCGTCGGCCATCACCACCCGGCCGCCGTGCGCCAGGGTCTGGAGGAGCTCGACCGTACCGTCGATGAAGCTGATCGAGCTCTTGGCGAGGAGCGCCTCGTTGCCGGTGAACGGCTGCAGCTCGGCGAACCAGGCGAGCCGGTTGAGCAACCCGGCCCGCGTGCCGGCCACGCCCTTCGGCGCGCCGGTCGACCCGGAGGTGAAGATGATCGACGCGAGGGAGGCCGGATCGTCGGTGGGCGCTGGTGCCCGGCGGGCGGCCGGAACGTCCGCGAGGTGCAGCGCCGGCGCGCCACCGGGCGGCTCGCCGTCGGTCAGCACCAGGGCCGGGCGGGCCTCGTCGATCATGTATCGGAGCCGTCCGACCGGGTACTGCGGGTCGAGCGGCAGGTACGCCGCACCTGACCGGACGATAGCGAGCAGCGCCACCACCAGGCCCGCCGACCGCGACACGTGCAGGCCGACCGTACGCTCCGGTCCGGCACCGCGCCGCGCCAGCTCGGCCGCCAGCGCCGCCGACCGCCGGTCCAGCTCGGCGTAGGTGAGCCGCCTGTCACCATCGATCACGGCCACGTCCGTGCCGAAGCGGAGGAGGGCCTGCTCCAGATAACCGGCCAGACCGGTCGGTGGTGCCGGGTGCGCGGTGTCGTTGCGCTCCTCCAGCTGCCGGCGGCCCTGCTCGCCAAACGGGTCGACGTGGCCCAGTCGCCGGTCCGGCTCCGCGGTCATCGTGGCCAGCACGGAGACCAGCGCGGCGAGCACCGCCCCGGCGGGCTGTCCCGGCGCGTGGTCGAGCCGCAGCCGCAGCCGGTCGCCGGGCACGACCGCGAGCATCAGCGGATAGTGCGTCGCGTCCGTTCCGTGCACGCCGGTCAGCCGCAGGTCGCCCGCGTGCACGCCGAGGTCGCCGGAGGGGTAGTTCTCGAAGACGACGACCGTGTCGAAGAGCTCACCGACGCCGACCGCGGCCTGGATCTCGGCCAGCGACAGGAACTCGTGCGGCTCCAGGTCGAGGCGCTGGCCGCGCAGCCGCACCGGCACCTCGTTCAGCGTGGTCCGCGGAGACAGGCGCACCCGGACCGGCACCGTGTTGATGAACAGCCCTGGCAGCTCCTCGATGCCGGCGATCTCGGCCGGGCGCCCCGCGGTGACCACGCCGAAGACCACGTCGTCCCGGCCGGTGAGCGCGCCGAGTACCACCGCCCAGGCGCTCTGCACCACGTCGCTGAGCGTCACACCGAGTGATCGAGCCAGCCGTACCAGCGCGTCCGTGTGTTCGGCGCCGAGCAGCGTGCCGGTCTGCCGGGGAGTCGTCGGTGGCGTACCGTCCGCGGCCACCAGCGTCGGCTCGTCGACGCCGGCCAGCGCGGCGCGCCAGGCCGTGGCCGCGGCCTCGGTGTCCCGCCCGGCAAGCCAGGCGAGGTAGGCCCGGTACGGCACCGGCGGCGGGAGCGCCGCCGGTGCACCGCCTGCCGCGTAGAGCGTCAGGAGCTCGCGTACCAGGATCGGTACCGACCAGCCGTCCATCAGGATGTGGTGGCTGGTGATCGCCAGCCGGTGCCGGGCAGGGCCGGTGCGGGCCAGCAGCACGCGGATCAGCGGCGGCTCGGCCGGGACGAAGCGCCGGGTCCGGTCCGCGTCCAGCTCCCGTGTCATGGCCGCGTCCGGGTCCTCGCCAGCGCCGGTCAGGTCCGTCTCCCGCCACGGCGTGAGCACGCCGCGCGAGAGGATCTGCACCGGACGGTCGAGTCCCTCGTGGACGAAGGCCGCGCCGAGATGCGGGTGTCGGGTCAGGACCGCGTCCCAGGAGCGACGCAGCACCGCGCGGTCCAGGTCGCCGGACAGGTCGAGGACGAGCTGCGTGACGTAGACGTCCGGGCCCTCCCGGTGATAGAGGTGCTGGAACAGGAGTCCCTCCTGCAACGGAGAGAGCGGAAGGACGTCGATCATCCCGGACCTGCTCACCGTGGTGACCTCCACATCGACTCAAGGTGATCGATCTGCGCCTGGTCGAGCCCGGCGAGGTGCAGATCGGACGGTGTAAACCCGCCGTCGTCCGCTCCCAGCTCCGCCAGGCTGCGGGCCCGGTCCTGCCACGCGCCGGCCAGCGACCGGACCGCGTCCTCGGTCAGCAGCGCGGCCGGCCACGTCCAGGTCGCCCGCAGGATTCGGCCGCCCGGCCGGTCCTCGGCCACCACGTTCAGCGCGAGCGTGTGCGCGACCGGCAACTCCGGGTCGGCCGCGCCGCCGAGCGCGTCGAGCCCCCAGTCGACAGGCTCACCGATCCGGAAGACCCCCAGGTAGTTGACCGCGATCCGGGGCGCAGGCAGCGCGGCGAGCCGGGCGGACGTGCCGGCGTTCAGGTAGCGGAGCAGCCCAAAGCCGAGACCGTCGCCGGGTGTGGCCCGCACCTGCTCCTTGATCCGCTTGACCGCGTCGGCGGGGTCCCGGCCGGGCCCGGCGTCCAGCCGCACCGGGTACGTGCTGGTGAACCAGCCCACGGTCCGGCTGACGTCGGTGCCCGCGATCGTGCCGCGCCCGTGGTTCTCCAGCTCCACGACCAGGCCCGCGTCCGCCGCCGCGCCGAACGCCGTACGGCTCCGGACGGCCAGCGCCAACGCGGTCAGCACCAGGTCCTCCGTACCGCAGCGGAAGGCGTCGGGAACCGTGCCGAGCAGCGGTTCTGCGACGTCCGGGCCCAGCTCGACGGTGAGGTGCCGCAGTGTGCCGGTCGTGTCCCGGTCCGGCACCGGCGTCAACTCCGGCGGCAGCGCCGCCCCGTCGAGCACGCCGGCCCAGTACGGCAGCTCGGCCACCCGCTCCGGGCGCCGCGCCTCCTCGGTCAGCAGGTGAGCCCACCGGCGGAACGACGTGGCCACCGGAGGTACAGCGGCCGTGGAACCAGCCAGGTCCTCCAGGAGGATCCGCCAGGAGACGCCGTCAATCGCGAGGTGGTGGACGGCCAGGAAAAGCCGGCCAGGCTCGTCCGGGCCCGCATCGAACCAGACCGCAACCGCGGTGCGGCCCTCGTCCGGATCCATCCCGCCGACGACACGGCCGGTCTCCTCGGCGAGCACCTCGGCGCGCCGCGCGTCCGGCAGCCCGTGCACGTCGACCCGCTCCACCGCGATCGGCGCCGCGCCGGCCGGTCGTACCTCCAGCGTCCAGTTCCGGCGGCGCAGACGCAGCGCGTCGTGGCGGTCGGTGAGAGCGCACAGCATGCGGTCGAGCTGTTCCTGCCCGGTGTCGGCCGGCACGCTGATCAGCGCGGACTGGTGGAAGTGCGCGGTCGGGCCGCCCAGCTCGCGCAACCAGTGCATGACCGGGGTGAGTGGCAACGACCCCGTGCCGTCGTCGTGGGCCACGGCCGGGAGCGCGGGGGCGGGCGTGGCCACGGCCGCGAGCCCGGCCACGGTACGGTGCCGGAACACGTCGCCGGGCGTGAGCACCAGCCCGGCCCGGCGGGCCCGGCCGCTGAGCCGGATCGCGCCGACGCTGTCGCCGCCGAGCGCGAAGAAGTCGTCATCGATACCGACGCCGGCCACACCGAGCAGCTCGGCGAACGCCTCGCGCAGCGCGGTCTCGGCGGGCGTACGCGGTGTCCGGCCGGGACCGGCCGGAGCGAACTCCGGCTTCGGTAGCGCGGCCCGGTCGAGCTTGCCGTTCGGCGATCTGGGCAACTCCTCGAGGAACATGATCAGGTCCGGGACCATGTGGCCGGGCAGCGACCGCGCGGCGATCGCGCGCAGCTCCGCCGGGTCGGGGGGGCCGTCCACGGCCACGACGTACCCCACGATGTGCTGGGCGGTGCCGCGGTGGACCGTCACGGCGGCCTGCCCGACCGCGGGATGCTCCTGCAGTACGCCCTCGATCTCGGCCGGCTCGATGCGGTAACCGCGCACCTTGACCTGCTCGTCGGCCCGTCCGACGAAATCGAGCTGCCCGTCGGCCCGTAGCCGAACCAGGTCCCCGGTCCGGTACATCCGGGAACCGGGCGGGCCGAACGGGTCGGCCACGAACCGCTCCGCGGTGGCGCGCGGCTGGTGGCGGTACCCGCGCGCCACACCGGGCCCGGCCAGGTACAACTCGGCCGGCACGCCGACCGGCACCGGACACAGTCGCTCGTCGAGCAGCCGCAGCCGGACCCCGCGCAGCGGCGTGCCGATCGGAGCGCCACCTTCGGGGGTCAGCGGACCACCGACGGTGGCGGCGATCGTGGTCTCGGTCGGCCCGTACGCGTTCAGCACCCGGCACCGCCCGGCCCACCGCTGCAGCAGGTACGGCGGGCACGGCTCGCCGCCGATGACGATTGTGGTGCCGTCCGGCAGCGCGTCGTCGGGGAACGCGGCCAGCACCGACGGCGGCACCGCCAGGTGGCTCACCGCGTGCGCGGCCACCAGCGGCGCGAGGTCCTCCGCGACGTTCCATGCGTCGGTCCGGGGCAGCACGACCCGGCCGCCCGCCAGCAGCGTCACGCACATCTCCCAGTACGCGGTGTCGAAGCTAGGCGAGGCCGACTGCAGCATGCGGGTGTCCTCGCCCAGCCGGCCGAGCCGTTCCCGGGAGCCGGCCACCAGATTGACGACGCCTCGGTGCGGCACCTCCACGCCCTTCGGCCGGCCGGTCGAGCCGGAGGTGTAGATGACGTAGGCGGGGTGGTCCGGATGCGACCGTACGCGCGGGTCAGTGTCGTCCGCGGCCCGCAGTTCGGCGCATACCCCGGGGTCGTCCAGGTCCAGCACGGGATGCGTATCCGCCGCCGCCGCGCGCGCCAGCACCAGCACCGGCGCGGCGTCCTCGATCATGTATGCGATCCGCGCGGCCGGGTAGCCGGGATCGATCGGCAGATACGCCGCGCCCGCCTTCGCGATCGCGAGCAGCGCCTCGACCAGCGCGATCCCGCGCGGCAGTCGCACGGCCACCACGGTCTCCGGTCCGGCGCCGCGCGCCATCAGAAGCCGCGCGAGCCGGTTCGCGGCCCTGTTCAGCTCGGCGGCGGTGCGGGTGACCGACCCGGCCACGGCCACGATCGCGTCCGGATCGGCCGCCACCCGCGCCTCGAACAACGACGCGACGGTGTGCGGCGAGCCCGGGTCCGGCGCGGCACCCCCGCCGGTGGCCGTCCAGACCTGCTCGTCCGGGGTGAGGATCTCCAACGCGCTCACGGCCACGTCGGGCTTCACGACGATCTGGCGCAGAATCATCAGGAGCCGGACCGCCAGCGCTTCCACGGTCGCCGGCCGGAACAGCTCGGTGCGGTACTCGAGGCTGCACTCGACGCCGTCCGTGCCGAAGTCGCCGAGCACCCGCTCGCTCAGGCCGAGGGTGAGGTCGAAGCGGGCGATGCCGCTCGGCAGCGGCTCCGGACTGGTCCGCAGGCCGGGCAGGCGCAGGTCGAGGCCCGCGTTGTTGTCCAGCGCGAGCATCACGTTGAACAGCGGATTGTTCCCGGCGGCCCGGTCGGCGCCGACCGCGTCGACCAGGCGCTCGAACGGCAGGTCCTGGTGTGCGAACGCCGCCAGGTCCGTCCCGCGCACCCGGCCGACCAGCTCCCGGAAGCTCGGATCGCCGCTCACGTCCGTCCGCAGCACCAGCGTGTTCACGAAGAAGCCGACTAGATCGTCCAGCTTCTCGTCGGACCGTCCGGCGACCGCCGTGCCGATCGGGATGTCCGTGCCCGCGCCGAGCCGCGAGAGCAGCACCGCGAACGCGGCCTGTACCACCATGAACAGCGTCGACCGGGTCTCCCCCGCCAGCTCCAGCAGGCGCGCGTGCAGGTCGGGGCCGATGACGAACCGGTGGGTGGCGCCCGCGTAGCCGAGTTCCAGCGGCCGAGGATGGTCGGTGGGCAGCGCGAGCCGCTGCGGCATGCCGGCCAGCGTCTCCCGCCAGTACGACAGCTGCGCGCCGGCCGTGCTGTCCGGATCTCCCGTGTCGCCGAGCAGGTCCCGCTGCCATGCCGCGTAGTCCGTGTACTCGACCGGTAGCGGCGGCTGTACCGGTGCCCGACCGGCCCGACGCGCCTCATAGGCCAGCGCCAGGTCGGCCAGCAGCGGGCGCAGCGACCACCCGTCCGCCGCGATGTGGTGGATCAGCAGGAGGAGCACGTGCTCGGTCGCCGACCGCCGCGACAACCAGGCCCGGATCGGGAACTCCGTCGCCAGGTCGAACGCGTGACCGGGATCCCCCTCGCCGACGGCCAGCCGGACCAGTCCGGGACCCGGCGGCGTCACCACCATAAAGGGCTCGCCGTCCCGCTCGACCACCGTGGACCGCAGCGGCTCGTGCCGGCACACCACGTCGTTGACCGCCGTGCCAAGTGCCTCCGCGTCGACCTCGCCCGACAGCCGCAGCAGCAGCGGCACGTTGTAGGTCGCGCTCGCGCCCTCTAGCCGGTGCACGAACCACAGCCGCCGCTGGGCGAAGGACAACGGCACCATTCCCTCGCGGGTACGCCGCCCCAGCGCCACCCGATCGGCGGTACCCAGCCGGCCCGTCAGTCCGGCGGGCGTCCGCGCATCGAACAGGTCTTGAAGGGACACCGTCAGGCCCAGCAGCCCCCGGATCCGGCTCACCACCTGGGTCGCCAGCAGCGAGTGGCCGCCCAGCTCGAAGAAGTCGTCGTCGATGCCGACCCGCGGCACGCCCAGCACGTCCGCGAAGACGCCGCAGACCAGTTCCTCGCGCACCGACCGCGGACCGCGGTTCCCGGCCGGCGCCGCGACCCGCGCGGCCGGCAGCCGGGACCGGTCCACCTTCCCGTTTACCGACAGCGGCAGCTCGTCGAGCACCATGAGCAGGCCCGGCACCATGAACTCCGGCAGTCGGGCGCGCAGGTACTCCCGCACCTCCGCCTGGAGGGTGGCGTGCCGGGACGCGCGGGCCGGCACGTTGGTCCACGGCCCGTCGCCGTCGCCCGGCCGGTAGGCGCCCGTCACCGGCGTGCCGTCCGCGGCGCCGGCGACCAGGACCGCCTCGCAGACGTCCCGGTCCTCCGCCCAGGTGACGACGGTCAAGTACCCGTGCCGGCGGCCGGCCGCGACCACGTGCTCGCGCCGGTCGCCCGGTACCCCGGTGATCCTCAGGCGGTCCGGCGCGTCGGCCAGGCCGTCGACCACCTTGTCACGGTCCCAGGACAGCCCCGGTACGTCTCCGAGGTCGATCGGCACGGTCGGCGCGGTGTACAGCACCGCCTCGTACCGGTAGCGGGTCAGCTCGTTGTCCCGCCGCCCCCGCTTGACGCGGATGTCGACGCCGGACGTCCCGGCGAGCCCGATCAGGAACTCCGGCGCCACCAGCAGTTCCCGCTCCTCCGCGGCGAGCCGCTCGGCCAGCACCGCGGCCTCCCCGGGATCCGCGTCCTGGCCGAGCCGGACGGCCGCGACCGCCGCGTAGAGCGCACGGGCCGCGCGCGGGTCCCGGAGGTCGCCCAGGTAGATCGCGCCGCCCGGCGCGAGCAGCCGGACCGCCTTCTCCAGCACATCGGTGAGGTACTCGGCACTCGGGAAGTACTGCACCACCGAGTTCAGGATGATCGTGTCGAAGCCGGCACCGGGCAGCGTGTCGATCGCGTCCGCCGGAACCGGGTGCAGCCGCACCCGGTCCCGGAGGCCGGGCCGCGCCACCACGTGCCGCCGCAACCCTTCGATCGCCTCCCCGGAGAGGTCCGTCCCCCAGTACGTCTCGCAGTCCGGCGCGAGCGGCGCGAGCAGCAGGCCGCTGCCGACGCCGATCTCCAGCACCCGCCGCGGGCGCAGCCGCCGGATCGCGGCCACCGTCTCGGCGCGCCACTCCCGCATGTCGGGCAGCGGGATCGGCGCCCCGTCCAGTGCGCTGTGCCAGCCGGAGAAGTCCTCGCCGAAGCCGGCGTCGGCACCGGTCTCCTCGTACTGGCTGCGGAACACGTCCCGCCACGCGTCCACCTGGGCCGCCTCACCGCCGGACGGCGCGTCCGGGGCGGGCACCAGGTAGCCGATCAGGCCCTGATCCCGTACGGTGACGGCCGCTGCCCGCACCCGCGGGTGCGCGGACAGCATCGCCTCCACCTCGCCGGGCTCGATCCGGTAGCCGCGCACCTTGACCTGGTCGTCCGCCCGCCCGGCGAAGCCCAGCGTGCCGTCCGCCGACCAGCGGGCCAGGTCGCCGGTGCGGTACATCCGGTCGCCGGGCGCGCCGAAGGGGCAGGCGACGAAGCGCTCGGCGGTGAGGCCAGGCCGGTGCAGGTACGCGTCGGCGAGGCCCGGACCGGCGACGTACAGCTCCCCGGTGACGCCGGGCGGCACCGGGCGCAGCCGCGCGTCCAGCACATACACCCGCATGCCGTGCACCGGCCGGCCGATCGGCGGCACCCCGTCCCCGGTCAACGGTGAGCTGATCGTGGCACACACCGTGGTCTCCGTCGGGCCGTACGCGTTGAACATCGTCCGGCCCCGGGACCAGCGGCGCACTAGATCCGGTGGGCAGGCCTCGCCGGCCACCACCAGTGTCGTGACCGAGGGCAGGTCACGGTCGCCGAGCGCGACCAGTGCGGAAGGCGGCAGCGTCAGGTGGGTGACCCCGAACTCGGCAGCCGTCGCGGACAGCGGGTCTCCGGGCAGCAGCCGGGCGGCCGGCACGGTGACCAGCGTCGCGCCGGTCAGCAGCGCCATCACCAGCTCCCAGAACGCCGCGTCGAAACTCGGCGACGCGAACTGCAGGACCCGGCTGCCCGGTCCGGCGCCGAACCACGCGCGCTGCGCCTCGGCGAGCGGAGCCGCCCCACGGTGGCTGACCACCACGCCCTTCGGTCGTCCGGTGGACCCCGAGGTGTAGAGCACGTAGGCGGGCGCGTCCGGGGGAACCGCGACGCCGCCCGGTCCGGCGGGCGCGGCGGCCAGCTCCGCCACGATCTCCGGATCGTCCAGGAACAGGTCGGCCGGGCGCCCGAGCTCCGAGGCACGCGTGGTCACCAGCAGCGTGGGCCGGGCGTCGTCCAGCAGGTAGGCGATCCGGGCCTGCGGGTACGCCGGGTCGACCGGCAGGTACGCGGCGCCGGTCTTGCCTACTGCCAGCATCGCGGTCACCAGGTCCGGCCCGCGGTGCAGCGCGAGCGCGACGATCCGCCCCGGCCCGACGCCCCGGCCGCGCAGCAGGTACGCCAGGCGGTCGGAGCGCTCGTCCAGCTCGCGATAGGTGAGCCGGCCGGCGTGGGACAGTATCGCCGGCGCGTCCGGCCGGAGCCGGGCCTGCCGGGTGAAGAGCTCCGGCACGGACGCCGCCTCGGGCACCGCGCGTCCGGTGGCGTTCCAGGTCTCCAGCATGAGCCGGCGCTCGGAGTCGTCGATCAGGCTGAGCGCGCCGATGCGCCGGTCGGGGTCGGTGGCGAACCCGCGCAGCAGCCGGTCGAGCCGGGTGGCGAGGCGGTCGACGGTGTCCGCGTCGAACATCGCGGTCGAGTACTCCAGGTATCCGTCGAGACCCCGCGGCCGGCCGTCCGGGGCGTACGCCTCGTTGAGGCTCAGCGACAGGTCGAACTTGGAGACGCCGGGCGTGGTGTCGACCGGCTCGACCCGCAGGCCGGGCAGCGAGTAGTCCGCGGCCGGAGCGTTCTGCAGCACCACCAGAACCTGGAAGAGCGCCTGGTGGGACAGCGACCGCTCCGGGTTCAGGTGCTCGACCAGGAGGTCGAAGGGCAGATCCTGGTGCGCGTACGCGTCGAGCGCGGTAGCCCGGACCCGGTGCAGCAGCTCCCGGAAGGTCGGGTCGCCGCTGGTGTCCGTGCGCAGCACCAGCGTGTTGACGAAAAACCCGACCAGGCCCTCCAGCTTCTCGTCGGTACGACCGGCGATCGGCGCCCCGATGGGCAGGTCGGTGCCCGCGCCGGAGTGGGTCAGCAGCACCGCGAACGCCGCCTGCACCACCATGAACAGCGTGGTGTGTGTCCGCCGGGCGAGGTCCAGCAGCTCCGCGTGCAGCCCGGCGTCGAGGTGCACGGGGAGTACGTCGCCGACGAACGTGTTGATCGCCGGGCGCGGCCGATCGGCCGGCAGCGTGAGCTGTTCGGGCATGCCGGCCAGCGTGTCCCGCCAGTGGGCCAGTTGCGCCCTGGCCACGCTCGCCGGGTCGTCCGGGTCGCCGAGTAGGTCCCGCTGCCAGGACGTGTAGTCGGCGTACTCCACCGGCAGCGGCGCCCACGCCGGAGCCCGGCCCGCGCGACGCGCCTCGTAGGCCGTGGCCAGGTCGGTCAGCAGCGGGCGCAGGGACCAGCCGTCCGCCGCGATGTGGTGCACCAGCAGCAGGAACACGTGCTCGGTCGCCGAGACGGAGAACAATGACGCCCGAACCGGGAACATCGCGCTCAGGTCGAACGGGTAGCGCACCGCCTCGTGCAGCACGCCGGGCAGGTCGTCCTCGTCGACCTCGCGGACGTCCAGGCGCACCAGGCCGGCGGCGGGCGGGGAGACCACCATGGCCGGCCCATCCTCGCGACCTTCCACCGTGGACCGCAACGGCTCGTGCCGGCACACCAGGTCGTTGACGGCCGCGCTCAGCGCCTGCACGTCGACCGCACCGGACAGGCGCAGCGCCAGGGGCACGTTGTAGGTCGCGCCCTCGCCCTCCAGGCGGTGCACGAACCAGAGCCGGCGCTGGGCGAAGGACAAGGGCACCGTCCCCTCCCGGGCGTGCCGGCCGAGCGCCGGACGATCCGCGGTGTTCAGCCGGTCCGCCAGGCCGGCGGGCGTCCGTACCGCGAACAGGTCCTGGATCCGCAGCTCCAGCCCGAGCAGGCTCCGGATCCGGCTGACCACCTGGGTCGCCAGCAGCGAGTGGCCGCCCAACTCGAAGAAGTCGTCGTCGATGCCGACGCGTGGCACGCCCAGCACGTCCGCGAAGACGCCGCAGATCAGCTCCTCGCGTACCGACCGGGGGCCGCGGCCGCCCACCGCTGCCTCGCCCGTCACCTCGGGCAGCCGGGACCGGTCCACCTTCCCGTTCACCGACAGTGGCAGTTCGGGCAGCACCGCCCACAGCCCAGGGACCATGAACTCCGGCAGCCGGGCGCGCGCCGCCGCCCGTACCCGTCCGGTGTCGATCGGGTTGCCGGCCGCGGGCACGAGGTAGGCCACGAGCCGGCGGCCGACGGCCGGGTCCCGCACCACGGTCACGAACGCCTCCGCGACCGCGGGGTCCTCGGCGAGCACCGACTGAATCTCGCCGAGCTCGATCCGATGGCCACGGATCTTGACCTGGTCGTCGTCCCGGCCGACGAACTCCAGCTCACCGTCGGTCCGCAACCGCACCAGATCCCCGGTGCGGTACATCCGCCCGCCCGGCGCACCGAACGGGCATGCCAAGAACCGCGACGCGGTCAGGCCCGGCCGTCCGAGGTATCCGCGCGCCACGCCGTGGCCCGCGAGGTACAGCTCGCCGGTCACGTTCGGCGGCACCGGGCGCAGCCGTGCGTCCAGCACGTAGCCGCAGTCGCCGTCGAGGGTCCGCCCGATCGGCACGGTCTCGGCGTCGTCCGGGACGTCGGTCACCACGCCGGCGTACGCGAAGGTGGTCGTCTCCGTAGGGCCGTAGACGTGCACGACCCGCGTCCGCGGGCAGCTCCGCACTGCGCGCCGAACCGTGCTCGGCGACACCAGCTCTCCGCCGAACCAGATCTGGCGCACGCCGGCCAGCGCGGCGGGCCGCTCCTCGATCAGGTGGTTGAACAGCGCGGTGGTGAGGAAGACCGCCGTCACCGCCCGGGACTCGAGCAGGCCGGCGAGGCGCAACGAATCCGTTGTGCCGGACGGCGCGAGCACGCACTGCCCACCGCGCAGCAGCGGCACCCACATCTCGTAGGTCGAGGCGTCGAACGCGTACGGCGAGTGGACCAGGACCCGCTCGTGGCCGTCGTCCCAGTGCCGGTCACCGGCCAGGCTCAGCACGTTCGCGTGGGTGACCCCGATACCCTTCGGCTCGCCGGTGCTGCCGGAGGTGAACATCACATACGCCAGGTCGTCCGGGCGGCCGGTGTGCAGCCTCACCGGCTGTGGTATCGACGACGCCGGGTCGCCGATCCGGACCACGGGTCTGCCGCCCGCCTCCTGGTGCGCGGTGTCCACCAGAAGCGCGGTAACGCCGGCCCGGTCGAGGACGAACTCGCGGCGCCGCGGCGGGTCGCCCGGATTCAGCGGCACGTAGGCGGCGCCCAGCCGCAACACCGCGAGGGTGGCCGCGATCAGCGCCGGCGAGCGCTCGACCAGCACCGCGACCCGGTCGCCGGGACGGACCCCGGCGTCGCGCAGCCGCGCAGCGAGCACGGCCGCCGCCTCATCCAGCCGTCGGTACGTCCAGGTGTCGCCGTCCGCGGCCCGGATCGCGACCGCGTCTGGCGTCCGCGCGGCCGTCTCCGCGAACCGTTGCTGCACGGTGGTGCCGGGAGCGGTGCCGAGCGGGCCGCCGTTCCACTCGTCCAGAATCCGGGCCCGTTCCGCCGGGGAGAGCAGCGTGATGTCGCCGACGCGGACCTCGGGATCCCGCACGGCCGTGTCCAGCACGCGCACCAGCCGCTCGCCGAGCAGCGCCACCGAGGCCGGGTCGAACAGGTCGGCGGCGTACTCGATGACGCCGCGGAGCCCGGCGTCCGGCTCCTCGTCGAGGCTCACCGTGAGGTCGAAGCGGGAGGTACCGGTACGGATCACCTCGGCGCGCGCGCCGAGGCCGGCCGGCACGGTGGGGCGGGCGTGTTGTTCAGCACCAGCATCACCTGGAACAGCGGCTGGTGGGACAGCGACCGCTCCGGGTTGAGGTCCTCCACCAAGCGCTCGAACGGCAGGTCCTGGTGCGCGAACGCCGCCAGGTCCGCCGCGCGCACCCGGCCGATCAGCTCCCGGAACGTCGGGTCGCCGCCCAGGTCTGTCCGCAGCACCACGGTGTTGACGAAGAACCCGACGAGGTCGTCCAGCTTCTCGTCGGTCCGGCCCGCCACCGCGGTGCCGATCGGCACGTCCGTGCCCGCGCCCGACCGACAGAGCAGCACCGCCAGCGCGGCCTGTACCACCATGAACGGCGTCGACCTGGTCGCCCGCGCCAGCTCGACCAGCCGCGCGTGCAGTTCAGCGCCGATGACGAACCCGTGGTTGCCGCCGGCCTGGTCGCGCACGGCCGGGCGCGACCGGTCGGCCGGCAGCGCGATAGCCGGTGGCAGCCCGTCCAGCGCGGCACGCCAGTGGTCCAGGTCCGCAGCCCACGCCCCGTCCTCCTCGCCGGCCAGGTCCCGTTGCCAGAGCGCGTAGTCCGCGTACTCGACCGGCAGCGGCTCCCACACCGGGGCCCGGCCCGCCCGACGCGCCGCATAGGCGATCGCCAGGTCGCGCAACAGCGGCCCCACCGACCAGCCGTCCGTCGCGATGTGATGCATCAGCAGCAGAAGGACGCGCCCGTCGAAGAACAGCGCGCGGATCGGCAGCTCCGAGGCCAGGTCGAAGGCGTACCCGACCGCGTCCTCCGGCGCGCCCCGGCCGGCGACGATCTCGACCAGGCCCGGCCCGGGCGGGGTCACCACCAGGTACGGCTCACCGTCCCGCTCCGCCACGGTCGAGCGCAGCGGCTCGTGCCGGCACACCACGTCGTTGACCGCCGCGCCCAGCGCCCCGGCGTCGACGTCACCGTCGAAGCGCAGCGCCAGCGGTACGTTGTAGGTGGCCCCGGCACCGGCCAGCCGGTCGACGAACCACAACCGTCGCTGCGCGAAGGAGAGTGGCACGCCGCCGTCCCGGTCGCGCCGCCGCAGGCCGCCCCGGTCGATGGCGTCCAGCCGCTCGGCCAGTCCGCCCGGCGTCCGCAGGTCGAAGAGTTCCTGGATGGACACCTCGACGCCGAGTTCCGCGCGCAGGCGGATGATCAGGCGGGTGGCCAGCAGCGAGTGGCCGCCGAGGTCGAAGAAGCTGTCGTCCGGCCCGACCTGCGGAACCCGCAGGACATCGGCGAAGAGCCGGCAGAGGTTGCGCTCGAGATCGGTCTGGTGCCGATCCTGCGGTGCTGCTGGTGCCACTCGGTCGGTCCCCGGGGCGGGCAGCGCGGCCCGGTCGACCTTGCCGTTCGGCAGCAGCGGCAGCTCGCCGAGCACTACGAACGCGTCCGGTACCAGGTATTCCGGCAGCCGGGCCGCCGCGAACGCCTTGAGGCTGGTGGTGTCCCGGCCCGCGGCCGAGGCCGGCACCACGTAGGCGACCAGCGCGTCGTACCGGGCCACGGCCACGATCTGTGCCACGTCGGGGTGGCGGCCGAGCACGGCCTGCACCTCGCCGGGTTCGACCCGGTGGCCACGGATCTTGACCTGGTCGTCGTCCCGGCCGACGAACTCCAGCTCACCGTCGGTCCGCAACCGCACCAGATCCCCGGTGCGGTACATCCGCCCGCCAGGCGCACCGAACGGGCACGCCAAGAACCGCGACGCGGTCAGGCCCGGCCGTCCGGCGTACCCGCGGGCGAGGCTGTTGCCGGAGACGTAGAGCTCGCCGACGGCACCGGGACGGACCGGGCGTAGCGCATCGTCGAGCACGTGCACGGCCGTGCCACGCACCGGGGTACCGAGCGGCGGCGGCCCGTCGCCGGCCAACGGCGTGCTGATGGTGGCGCACACCGTGGTCTCGGTCGGGCCGTAAGCGTTCATCATCCGGCGTCCCGGCGCCCATCGGCCGGCGATCGCCTCGCCGATCGCCTCGCCGGCGACCAGGAGCGTACTGACGCCCGGCAGCGTGGCTTCGCCCATCGCGGACAGCGCGGAGGGTGGCACCGTCAGGTGCGTCACGCCGTGCGCCCCAGCCAGCGCGGCCAGCTCGTCGCCGGGGCGCAGCCGGTCCTGCGCGGCCACCACCAGGGTGGCGCCGGCAAGTAGCCCCATCGCGGTCTCCCAGAAGGATGCGTCGAAGCTGGGCGAGGCGAACTGCAGCACCCGGGCGCCGGGGCCAGCGCCGAGCCGGTCCCGCTGCGTGGCGACCAGGTCGCCGACGCCGGCGTGCGTGACCACCACTCCCTTCGGCCGGCCGGTCGAGCCGGAGGTGTAGATGACGTAGGCGGGATTGCCAGAAGCACAGGTCCGGGCCGCCGTCACGGCTTCAGCCTCGAGGTCGAGCTCGTCGAGCCGGATGACCGGCGGGCCGGCCGACTCGTACGCCTGGTCGGTCAGCACCAGCAGCGGGTGCGCGTCGGCGAGCATGAACTCGATCCGGTCGGCCGGGTAGGACGGATCCACCGGCAGGAAGGCCGCGCCCGCGTGCCACGTCGCGAGCATCGCCGTCACCAACGCCCGCCCGCGCGGCAGCATCAGGGCGATCACCGTCTCGGCGCCGGCACCGCGGCGGGCGAGCACCGTGCCCAGCCGCTCGGCGTCCGCGCGCAGGTCCCGGTAGGTGACCACGTCGCCGCCGGCCGCGTCGTCGACGAGCGCCAGCAGATCCGGCCGGGCGTCCGCCGCCGCGGCGAAGTGCGCCCACGCGGTCCCGGTCGGACCCGGCGACTCCGGGCCCGGGCCCGACAGCCGCGCACCCGCCGCCGCGTCGGCCAGCCGTTGCGCCACGTCCGCCGCGTGCCGGGCCACGCTGGCCTCGTCGTACACGCCGCCGTTCGCCCACAGTTTGAGCTGCAGCCCGCCGGTCGCGGACTCCTGCAGCATCACCTCCAGATCGTCCACCGGACCGATGGCGATCCAGTGTCGGACCGCGGCCCGGCCGCCGAACGCCGGCTCGGCCGCGAAGGAGAGCACGTTCACGATCGGCCCGAACAGCTTCGGCCGGTCGGCACCGCCGCGCAGCTCACGGCTCAGCCGCTCGTACGGGTAGCGCTGATGGGCCGCTGCGCCGCGGATCCACCGGTCGACCTGCCCGGCGAGGTCGTCCAGGCCGGCCCCCTCCGCGATCCGCAGCCGCATGGGCTGCATGTTCGCCAGCATGCCCGGCACTGCACGCGCCACCGGCGTGGTCCGGCCGGTGACGGGCAGCGTCAGCACCAGGTCCGTCCGGCCAGTCAGCGCCCCGACCCAACTCGCGACGGTCGCCACAGCCAGCCGTGACCAGCGGATCGACAGCCGGTCGGCCCGCGCCCGGAGACCGTCCAGCACCGGCACACCGAGATCCGTCCGGTGCAGCACAAACTCCGGTTGCGCCGGGGCGGACCGGCCACCGAGGAGGATCGGCGCGGGCACCGGACTGAGCAGCCCGGTCCAGTGTCGCCGGTCGTCCTCCGGCGCCGCGGAGTTGAGGTAGGACGCGTCCTCGGCCAGCAGGTCGCGCAGCGAGCCGAGTGCCGGGCCGACGTCGCGGCCTGCCAGTAGCGCGTCGTAGACCTCCGCCGCGCGCCGGGTCAGCAGCCATACGCCGTACCCGTCCAGGACGGCGTGGTGGTAGCGCTGGTACCAGAGGTACCGCTCGTCGCCGACGCGCAGCAGGGCCTGGGCGTGTGTCGGCCCGGTCGAGAGATCGACCGGCCGCGACAGCTCGGCCCGCATCCAGGTCTCCGCTTCCGCGATCGGCACGGCCGCGGACCGCAGGTCGACGACCGGCACCGGCGTCTCGGCCGACGCCGTGAGGTATTGCGCGGGTCCGTCCGCGTCGGCGCGGAAGCGGGTGTGCAACGCCTCCGTCTCGCGCACCGCCGTGCGCACCGCCGCGATGAACTCGGTGACCCGGATCGGCCCGTGGATCTCGAGGTACGAGGCCTGGTTGTACCCCCAGCCGGTCGGATCGAGCTCATGCCCGTAGTAGGAACCCAGCTGCGCGGCCGTCAACGGCCACCGCTCCCCCGTGTCGAACATCGATCTCACCTTCGCTCGGGTCAGTCCGTCAGCCGAGCCAGCCCGTCGGCCAGCTGTCGCAGGGCGTCCTTGGCGGCGGGCAGGCCCATCGGGTCGTCCGCCTCCATCGCTTCCCGGTACGCCTCCGGTTCGTCGCCGAAGAGCAGGCTCGTGGCCGCGCGGAAGCGCAGCGCGGCCGGGTCGTCGCCGAAATGGTGGCCGCCGAGGACTGCGATCCCGCACCTGCGCAGCAGCTCCCGCTCCAGCGAGGCGGAGTCGTGCACGCCCTGCCGGGCTAGGTCACCGGCGAGCTGACGGAAGTCGGGGTAGATGTAGAAGCCCCGGACGGCGCCCGGCAGTTGGCACCGGCAGCCACCACCACCTGGTGCACGGCCTGGGTGGCGGCCGCGTGCATCCGCGCGCCGGCCCGGACGTAGTCGGCCAGGTCGGGCGGCTCGCCGAACGCGTACTCGACCACCGACTGCACCGGCCCGGCCAGCGACGACCACACCTCGCTCGCGGTCGCCAGCACGCGCGAGCGCAACAGTTCTCCCCGCGCACCGGCCGGGAACCGGGCCGCGCCGGCCCGCCAGCCACCGAGCGCGTGCGTCTTGCTCAGCCCGGTCGTGATCACGGTACGGTCACCGGCCACCTCGGCCGGACTCAGGTAGTCGCGGTCCGGATCGTGTGCCAGGTCCCGGTAGATCTCGTCCGCCACCAGCACCAGGTCGTACGCGTCCGCGACGTCGCAGATCCGTCGCACCACGCCGGGCGGCGCGGTGGTGCCGGTCGGGTTGTCCGGCAGCGCCATGATCAGCAGCCGCGGGTGGCCGCCCTCGGCGCGCGCCCGGTGCACGGCGCTCGCCAGCAGGTCCGGGTCTGGGACGCCGCCGCACTCGGCGGGGACGTCGACCCAGAAGACCCGCCGGCCGAGCAGGCGGGCCTGTGGCGCGTACGTCAGCCAGCACGGCCGGGGCAACAACACGTCACCGTCCACGGCCGCGATCAGCGCGAACAGCAGCGGCTTGCTCCCCGGTGCGAGGACGACCTGGTCGGACTCGGTCGGCAGCCGGCGCCGTCCGAAGTAGCCGGCGACCGCGGCCCGCGCGGCCTCGTCGCCGGCGACCGGCCCGTAGGCACGCCGGTGCGCGCCGGCCAACAGTGCTTCGACCAGGCCGGAGTGCAGGGGCAGCCGCGCCTCACCGAAGCCCAGGTGCAGCAGCCGCTCCCCACGGGCACGCCGGCGGTTGATCTCCTGGTCGAGCGCGAGGTTGGCCGACACGGCCCGGGTGATCATGCGGTCACCTCGGTCTGCGGGTGCGCCAGCGCGTGCCTGAGATCCGCCGGGGTGTCCGGGCGCGGGGTCAGCTCCGTGATCCAGGCCGCGTCCGGCGACCCGTCGGCACGGAACGGGCAGCCGACCAGGTCCGGGTTACGGGCCTGTAGGAACCTCAGCTGAAAGACCCCTCCGTCGGCGCCGTCGACCACGACCTTTCCCGCCTCGGTGGACATCACCGGACCGCGGACCGTGCGGGCCAGGCCCGGCAGCCGGCGGTACGCCTCGGCGAAGATCTCGGCGGCCCGCTGCAGCGGCACCCGGAAATAGTCGTGCGGGCCGGTGTCCCGCGCGACGAAGAGGTAATAGGGAACGCAGCCCGCAGCAATCTGGGCCCGCCACAGCGACGTCCACACGTCCGGGTCATCATTGACATGGGCGATCAACGGTGCCTGGCAATAGATGACGGCACCGGTCGACCGAATACGGGAAATTGCTTTCTCGGCCATCGGCGACGCAATTTCGCGGTCATGGCTGAAATGGGCCATGACCGCCATCGTCCGGCCCGATTCCACGACCTCGGCGAATAGCCGCAGCAGGTCGTCCGCGTCCGGGTCCGTGACGAATCGCTGCGGCCAGTACGCCGGCGCCTTCGTTCCCATCCTGATCACCCGCAGCGTCGGCACCGCCAGCAGCGGCCGCAGATGACCGCGCAGCCGGTCCGCGGACATCACGGCTGGATCGCCGCCGGTGACCAGGACGTCGTTGACCTCGGGGTGTTCCCGCAGATATCGCACCAGAGCGTCCGGGCCGGGCGCGGCGAACCGCAGGTCGGCGTCGCCCACGAACTGCGCCCAGCGGAAGCAGTACGTGCAGTACGCGTGGCACGTCTGCCCCTGGCTAGGGAAGTAGAGCACGGTCTCCCGGTATTTGTGCTGGAGACCGGGGATAGCGACGCCGTCGCGGCGGGGCACGTTGAGGTCGAGCTGCCCGCCCGGGTGCGGGTTCAGCTCCGCACGGATGCGGCGCACGACGGCCGTCACGCCGGGGTCCGCGTCGGCGCGGCCGTCCAGCGCGCGCAGCGCGGCGGCGTGCTCGTCGCTGAGCATGCCCGGTTGCGGGAAGACGAGCTGGAACATCGGGTCCGCCGGGACCCGGGACCAGTCGATGAGTTCATCGAGCACGTACTCGTTGATCCGGAAAGGCAGCACGCGGGAGAACATCCGCACCGTGTCGCGCACCTCGGCCGCCATCGGATAGCGGCGCACTATCTCGTCCAATTGACGTGGCCCGAATGCACGGAAACGGGACCCGCTCTCGATCGTCCGGTACACGTGTGGCGTCCCCCGTAAGAGCTCGACTGCCGATGCAGCGGTTCCGATCGTACGGAGACGGGAAGCGTACCCGTCCGGTTTGGCAATTTACGGACGTCAAGGTGGCAGCTTGTGGTCACTCCACTGCTCAGAGCGCTGTCGCGCCGTTTCGCGCCGCTAGCCTCGAGATCACCGGCTGGGAGCACCGCCGGTCATCTCCGTCCCTCTTCCGTGAGGAGCTGCGCTGCGATGACCCACTCCGTGGGGCCCGATGCGGGACCCGACCTCGCCATCGCCTCCGACGATCCACCCCGCCCCCCGACCGGGGTCGGCGACGGCCGCGCGTTGGGTGCCTGGCTCGACGTCATGCGCGCCTCCCACCCGGTGTGGCGCGATCCGCTGACCGGTTCCGCCCACGTGTTCCGGTACCACGACCTGCTGCACGTGCTGTCCACTCCGGAGGTCTACGGCTCGGACTTCACCGGCGTCATGCCGCCGTCCGACCCCAGCGCGCCCAACTTCGCGGAGGGCGTGCTGACCATGATCGACCCGCCGCGGCACGGCAAGCTCCGGCGCCTGGTGTCGCAGGCGTTCACCCCGCGGGTGATCACCGCGCTGGAGCCGCGCATCATTCAGCTGACCAAGGAACTGCTGGACACGGTGGCCGACCAGGACGAGTTCGACCTGGTCGCGGTCATGGCGCACCCGCTGCCGGTCATCGTGATCGCGGAGATGCTCGGCATCCCGGCCGAGGACCGGGAGCTGTTCCGGGCCTGGGGCGAGGCGCTGCTCTCCACCAACTACGAGTTGGAGACCGGGGAGGTACCGGACAACTCCGCGCTGCCACCGGACGTGGTCGCGCAGCTCACCGAGATGCGGGACTACCTGCTCCGGCACGTCGACCTGCACCGCCGTGACCCGCGGGACAACCTCACCAGCCGCCTGGCCTTCGCCGAGGTGGACGGCGACCGGCTCACCGACCAGGAGATCGTCAGCTTCCTCAACTTCCTGCTGCTGGCCGGCCACCTCACCACCTCACTGCTGATGGGCAACTCGCTGCTGTGCTTCGCCGAGGCGCCCGAGGCGGAGGCCGCCGCCCGGGCGAACCGCGCCCTGATCCCCGGGGCGATCGAGGAGGTGCTGCGGTTCAAGCCGCCGGTGGTGATGCAGGCACGGCTCACCGTGGTGGATACCGTGCTGGCCGGCGTCGAGCTGCCCGCCCGCACGCCAGTGATGGGCTGGCCGATGTCCGGCAACCGGGACGAGCGGCAGTACCGTTCGCCGTCCACGTTCGACATCACCCGCAACCCGAACCCGCACCTGACGTTCGGGCACGGCATCCACTTCTGCATCGGCGCGCCCCTGGGCCGGATGGAGGCGCGCAGCGTCCTCAACGAACTGTTCGACCGCTACCGGTCGATCGAGATCGGCGAACCCCGCTACTACGACCGCAGCCCGGACGTGTTCGGCGTCAAGGCCCTTCCCGTCACCGTCAAGCACTCCTGAGGACGACATGACTTCCGCATCGCACGACGAGGCACTCCAGGCCGGTCCGCCACCCGTGGTCGGCGATGGCCGCGCGCTCTACGACTGGCTGCGGCGCGCGCGCGACGCCGGCCCGGTCTGGCACGACACCGCCAACGACGCGTACCACGTGCTGCGGCACGACGAGGTGGTCGGTGTGCTCTCCGAGCCCTTGATCTTCTCGTCCGACTTCAGCTCCCTCGCGCCGCCACCGGAGCCGGGCATGCCGAACTTCACCGAGGCGTCGCTCAGCGTCACCGACCCGCCCATGCACACCCAGCTCCGGAAGATCATCAGCCAGGCGTTCACGCCACGCATGATCGCCGGGCTGGAGCCACGGATCACCGCGCTCGCGACCGATCTGCTCGACGCGATCGAGGGCCGCGACACCATAGAGATGGTCCAGGACCTGGCCGCGCCGCTGCCCGTCGTGGTCATCGCGGAGATGCTCGGCATCCCCAGCGACGACTGGGCCACGTTCCGCCGCTGGGCGGAGTACCTGCTCCCGGACGCCGCGGACGTCACGGCCGGACAGTTCGAGGAGGGCGGATACGCCAAGACCCGGGCCGCCGAACTGAACGAGATGGCCGACTACTTGCTGGCGCACGTGCACGACCGGCGCAGGAGCCCCAAGGACGACCTGTTCACGCGTCTGGTCGAGGCCACCGCGGACGGGGATCGCCTCACCGACAAGCAGGTAGTCAACTTCTCGGTCTTCCTGCTGTTGGCCGGGCACCTCACCACCACGCTGACGCTCACCAACGCCGTGCTCGCCTTCAACGACAGCCCCGGCACGCTGGAGAGGGTGCGCGCGGACCGGTCGCTGGTGCCCGGCGCGCTCGAGGAGGTGCTCCGCTTCCGTCCGCCAGTCTCTTTCCTCTACCGCTTCACCACGCAGGATGCCGTGATCGCCGGCACGCCGGTGCCGCCCGGGAAGATCGTCGTCAATTGGATCCACTCGGTCAACCGGGATCCGCGGCGGTTCGTCGAGCCGGACCGGTTCGACCCGGGCCGCTCGCCGAACCCGCACCTGACGTTCTCCCACGGGATCCACTACTGCCTCGGGGTACCGTTGGCGCGGTTGGAGTTCTCCGTGGTGTTCGGCGCGATCCTAAACCGCTACCGCGCCTTGGAGTGCGGCACGCCCGAGTTCCACCAGCGGCCGGACATCTTCGGCGTCACCCGGCTGCCCGTCACCCTCCACGCGGCCTGACGACCGGTGGAGACGACGACCGCGCACGGTCAGCGACTACGCCGGATGATCCAGGGACACCTGCTCTCTCGGGCCGTCTGCGTCCTCGCTGACCTGCGCGTACCGGACCTGATCGGCGAGGGGGCGCGCGACGGCCCCGAGTTGGCCCGGCTCACCGGGACCGACCCGGACGCGCTGATCCGGCTGCTGCGCGCCCTCGTCGCGTTCGAGGTGCTCGACGAGCGGGACGACGGATTCCGGCTGACCCCGCTCGGCGCCGGCCTACGCACCGACGCTCCCGCGTCCGCGCTGCCCTCGGCGCTGCTGGCGCACGGGGAGATCGGAGAGGCGTGGCAGCACCTCGGCACCGCCGTACGCACCGGCAACCCCTCCTTCCCGGACCTATACGGCACGGACTTCTTCCGCTACGTCGACCGGAATCCGGCATTCCGGGAGACCTTCGACCGCTCGCAGGCGGACGGCCTGGCGCTGGACGACCTCGCCGACGCGGTCGACCTCACCTGCGTCCGGCGGATCGTCGACGTCGGCGGCGGCGACGGCACGCTGCTCGCCGCGCTGCTGACCGGCCACCCGCACCTGCACGGCACGCTCCTCGACCTGGCCGCGCCGGCCCACCGGGCCCGGGAGCAGATGCGCGCGGCCGGTCTGGACGGCCGGTGCACCGTGGTGACCGGTGACTTCTTCACCTCGGTCCCGGCCGGCGGCGACCTCTACCTGCTGCGTCAGATCATGCACGACTGGGACGACGCACGATGCGTGACGCTGCTGCGCAGCTGCCGCCGGGCAATGTCGCCCGGCGCCCGAATCGTCGTGTCGGACCTCGTGCTGGACACCGGCCCGTCCGCCGTGCCCGACGAGTCGGCGGCGCTGATGGACCTGTACATGCTGACCGTCGTCGGCGGCCGGGAACGCACGCTCGCACAGTTCCATGACCTGTTCGCCCGCGCCGGCCTCACGGTCCGACGGGTGACCCGCCTCGCGGGTCGCACCGCCGCGATCGAGGCGGTCGCCGCCCGATCGGCGCACGAGGAGTAGACATGTTGCTAGGGCTCAGCGGCCTGGCGCTGTGGTCGCCGGCCGAGGTCGCCGATGGAAGGCTCATCGGTCCGGAGCAGCTACCCGCGCTGCGCGAAATCGCCACGTGGGCGGAACGGTTCCTCACCTATGGACACCCGGACCTGGGCCGGCAGGGGCCGGTCTGCCCGTACACCCGGCCCTCGCTCAATCGGCGGCTGTTCCACCTGACCTGCCTGGACCGCGACCTCCACGACGACAGCGTGCCCGAGACGCTGCTCGGCTACCGCGACCTGCACCGGGAGCTCGCCGCCGAGCTGCGGGAGGAGGACCGGCAGTTCCTCACCATCCTGATCGTCTTGCCGCGCGTGGACAGATCGGACCCGGAGCCGCTCAACCGGCTGCAGGCCCGACTGAAAACCGACTTCGTGCAGGAGGGACTGATGATCGGACAGTTCCACCCGGAGTGCGCGGAGCCGGGCCTGTGGAACCGCGACTTCCGCCCGCTCCACTCGCCGGTCCCGCTGCTGGCCATCCGGCACATGGTGGCGTTCGACCTGCCGTTCCTGCAGGCCTCGCAGCAGCACCTCGAGGCATACCTGGCCACTTTCGCACCGGCCATCCCGACCGCCGTCCGGTCCCGACTGGCGGAGTTTGCCACCCGGGAGATCCCCGCACGGTCGCCGGGCAGCACCGTGCAGGCCACCGCCTGACGGCACTGCCCACACGCGTCGTCGCGGGCGGCCCACCGGCCGCCCGCGACGACCCGTCAGCGAGGTCAGCGCGCGGCGTGCGCCTCCAGCTCGTCCGCGGCACGCGGCACGCCACCGGCCGCCTCGATCTCGCCCCGCATCCAGGCCAGCCGCTCCGCGACGGCCCGGTCGCCGATCAGATCGAGCACGGCGTCGCGAAGCCCGTCCGGCGCGGCCAGGCGGCCGAGACCCAGCTTCGCCAGCTGGAAACCGGTGATCCGGGCGGGGAGAGCGGGCGGCACGACCACCACCGGACGGCCTGCGGCGAGCGCCTCGGTCACGTTGCCCACGTCACCCTGGCTCACCACGACGGCCGCGTGCCGCAGCACACCCTGCGGGAGCGAGGCGTGCACCTCGACGTTCGGCGGCAACTCACTCAGGGACGCAGGATCGGCGCCCGGGCCGGGTGTCAGGACGACGTGCACCGGTGCTCCCACGAAGGCGCGGGCCAGGTCGGCGCCCTGCGGTGCGGACGGCACGAGCACGACGGGAAGGCCGTCGGCGGGCGGCTGCCAATCGTCGCGCGCCGGCTGCTCGCCCACGCACGGCCCGACGAACCGGAAGCGGTCGTCGAAACTGTCGGCCGCGGGCTGCAACGCCTTCGGCACGTACACCAGGTTGAACTCCTGCACGACCTCGAGCAGCTCGGCAAAGGTGACGTCCGTCAGCCCGTGCGCGGTGAGCAGCCGCTCGGTACGGTCCACCCAGGGCTTCAGCTCCGAGCGGGCCGCCCACCCGGCCGGGCTCAGCGGCTCGCCGAGCGCGACGCCGTCGTCGTCGAAGGGCTGCGTGTACGCGAACTCGTCGTTCTGCGCGAAGTCCGCGTACAGCTGGGCGGCCGGGAGTCCCCATTTGCGCGCCAGCACCCTGCCGGCCGTGCCACTGGCCACGTCGTACGCGATCAGGTCGGGCCGCTCGTCGCCGTAGGCCGCCTCCACCGCGTCGATCATGGCGGCGGAGTCGTCGACGCTGAGCGCGAGCATTGCGGCCTCCGCGCTCATCTCCTTCTCCTCGTGGACGGGGATCGACCCGTACGCCGACCCGTAGACCAGCGGCTCGACCCCGTACGACCCGACGAGTGCGGCCATCGGCTCGACGGTCACGAATTTTACGCTGTGCCCGCGCCGCACCAACTCCTTTCCGATCGCGAGATGCGGAGAGAGGCGACCGGGGTCGGGAATGCTGATGAACAGGAAGTGACTCGGCACGACAGTGACCCCCAGGCAGATCTTCGGCGGATTCGGCGCGAGACGCCGGAAATTGGCGTGATGCCGAGGTCACGGCCTCACGGCATCGATCGCAACCCGCATCCAACTCTACTTGACAGCTGCTGTCAAGTAGTGTGAGAATCGGCGCCGAAACGGGACCAGCCAATCCGGAGGAGTGCATCGTGAGCCAGCCAGCCGTGCGCCAGCCTGCTAAACCGATCGACCGCAAACGATGGTCGATTCTGGCCGCGATCTGCTTCGCACTGGTCATGGTGGTCATCGACAACACCGTCCTGAACATCGCGATCCCGACGCTCATGACCGAGCTGTCGACCACCGCCGCGGAGGCACAGTGGGCCTTCACCTCCTATCTGCTGGTGCTCTCGGGGTTCGTGCTGGTGGGCGGCGTCGCCTCGGACCGCTACGGCCGGAAGCGGATCGTCCTGGTCGGCATCGCGCTGTTCGGCACCGCCTCGCTGGCCGCCGCGCTCGCCACGGAGCCGTGGCAACTCATCGCCGCGCGCGCGGCGATGGGCTTCGGCGCCGCACTGCTCATGCCGGGCACGCTCGCGATCCTGATGCACACCTTCTCCGACGCGGAGCGGCCGAAGGCGATCGGCGCGTGGATGGCGGTCGCGGCGGTCGGCAGCTCGGGCGGGCCGATTCTCGGCGGCTTCCTGATCTCACACTTCTGGTGGGGCGCGGTCTTCCTCATCAATGTCCCGATCAGCATTCTCTGCCTGGTGGCGCTGGTGATTCTCGTGCCGGACGTGCCCGCCACCCGCAACGACCGCATCGACTGGATCGGCGCGGTGCTGTCCGTGATCGCCACCGTCTCCCTCGTCTGGGCGATCACCTCGGTGCCGGAGCACGGTTGGGCCTCGGCCGCCGTAGAGGTGCCGGCCATGATCGGCGTACTCGCGCTCGCCGCCTTTATCGCGTGCGAGCTGCGGGTCGAGTCGCCCATGCTCGACCTCGGGCTCTTTCGCAATCTACGATTCAGCGCCGCAGTGCTGGGCGGGCTGCTCGCCAGCTTCGGCATGGCTGGTTCGCTGTTCCTACTCACGCTGCACTTCCAGCTGCTGAACGGTTACACCCCGATCGAGGCGAGCATCCGGCTGCTGCCACTCGCGATCTGCACGCTGATCGGCAGCACCGCGATCAGCGTGATCGTCCTGAAGCGCCTGGGCGCGCCGCTGGCGCTCCTGGCCAGCATGGCGGTGGCCGCGATCGGCCTGCTGCTCATCGGCCTACTGCCGGCGGAGGACTATCTCAGCAGCCTCGCCGGGCTGATCCTGGTGGGCCTTGGCACGGGTTCCGCCGGTCCGGTGGCGGGCACGGTCCTGATGAGCTCCATCCCCTTGGAAAAGGCGGGCGCCGGCTCCGGCGTCAGCAGCACCATCCAGGAGCTGGGTAACGGGCTCGGCGTCGCCGTCCTGGGCACCGTACTCACGGCCTTCTTCGTCAACCGCCTGCCCGGGTCACTGCGCGCCGAGGGCGAGTCCTCGTTCACGGATGCGATCGGCCGGGCGTCCGGCGCGGCGGCGGACCAGGTCCGGGACGCGTTCGCGACCGGGCTCTCGTTCAGCCAGATCATCGGCGCACTGACCGTGCTCGGCGGTGGCTTGGCCGCCTCGGCCCTGCTCTGGATGACCCGTTCCGCGGCCACCCCGCAGATGCCGCCCGCCGACCAGCTGAGCACGCCGGCCGCGAAGCTCTGATCCCGGCCATCGGAAGATATGTATTCCCGCCCCCCTATGCGTAGCAGATTCGCGCTGTTCCGTCCTCGCCGATGGTAGTGAATCACTGGCCATCCATCACGGTCGCGATCGCGACGGTACGTCAGCGTCCAGTTGGATCTCGGCTGACGCGGGTTGGTTGCCGCCGAGCAGGGCACCGAAGACACCGAGCTGGTCCGGGTCGATCGGGGCGGCCGGTCTTTACCGTGGGCCTCGACCGCCCGTCGGTAGCGGGCGTCGAATGGCTCGATCGCGTTGGTCCTCAGATGACCTTGCAAATCTCGACGTCTCCGCGAGGAGGCCCAGCAGTTGCCGCGGAGGGCCCGACCGGAGATCAGGGCCCTGGGATCACCAGCTAGGCCATCTCGTGCCGGCGAGCGACTCCGCAGGCAACTGTCAGTAGGCGATGCGGCCAGCGCGGTTGTGGAACTCGCCCGTCGGCCCAGCCCTGCCGACGGTCGCCAGCGCGACGGTGACATACGTACCCTCGGTGACCGTCTGGTGGCCGATATGGTGGTGCGGCGTGCAACACGGTGTCAAGGGTCGAACCCCACCGCGGCGAGTTGTCGCGGGGCTGGAGGCGGTACGACCTGCCACGCGGCACCGCCGGTCGCGTACGGTGCTTTGGGCCGTACATAGTTGATCGTCCATGTGGAGGCGGGGCCTCAGCGCATGGAGTCCCGGGGAACGCCATCCGCTGCTGTGGGTTCAGCGCCAACGGATGGAACGCCGGCCTGCACGATTACGCCGGCTTTGTCGCGCCGCGCTTCCGCGAGACGACGGATGCGGTTGCTTCGGCGGCGGCGTGGGAGAGCTCGGGGAGGACGTCGCCGTAGAACTTGGCGGTGAAGTGGGGGCTGGAGTGGCGGAGCCGGTTGGAGATGACTTTCATCTGGACGCCGGCTGCGAGTCCCATGGTCGCGGCGCCGTGTCGGAGGTCGTGGAGTCGGATGGGTGGTAGCCCTGCTTGGGTGGCGAGGTGGTGGAAGTGGTCGGTGACGTCGGCCGGGTGGAGCCGACCGCCTGTTGGGGTGGTGAACACCAGGCCAGTCTTGGACCAAGCGGCACCGGCGGCGAGGCGTTCGCGGTGTTGCCGGGCGCGGTGGGCGCGCAGCACCGCCACGGTCTCAGCGTCGAGAGCGACGGTGGCTTCGCTGTCGGTGGTTTTGGGGGTGTCGATGGCGGTGGTCCAGCCGTGTTGGACGAGTTGCCAGCGGACCGTGAGGGTGTGGGCGTCGAGGTCGAGATCGTCCCAGTGCAGGCCGCAGGCTTCGCCTCGGCGCAGGCCCGTGAAGGTGATGAGGTGGTAGAGGGCGTAGAGCCGGTCTGCGGCGTCGTGGGTGTGGTCGAGGAATCTGCCGGTGTGTTCGGGAGTCCAGATCATGACGGGGCTGGGGGTTTTGCCGGTGTCGCGCCACGTTTTGATGCGTTGGTCGGTCCAGATGGTGGGCTTGGGTGGTCGGGCGGTGGGGAGTTCGATCATGAGGGCGGGGTTGGTGTCGATGTAGCGGTGGCGGCGCATCGCGTCGTTGAGGGCTTTGCGCAGGGTGGCGTGGATGACGTGCAGGGTCCGGTTGCCGACGATCCGCTGGTTCTTCACCTGGTCGCGTCTGGCTTGGTTGCGGCTGGCGCGCAGGGTGGCGATGGTGGTGTTGCGTTCGGCGATGGCGTCGTACATGGCGTCGATGTGGCCGGGGCGGAGCCGGTCGATGCGCAGGTGCCCGAGGTGTGGGATCAGGTACAGCCGGATGTGCCCTTCGTAGGAGCGCAGGGTGCCGGCCTTGATGTTCCGGCGTCCGGCGAGCCAGTCGGTCAGGTACACCTCCATGGTGGGCAGTTCGGTGGGGGTGATGTCGAGGTGCAGCGCCCGGCGGACCTGCTCCGGGCTGGGGACGGGCGCGCCGGCCTTCACTGCGGTCTCGATCAGGTCACCGGTCTTGACGGTGGCGTGGGGGTCGGTGGGGTCGGGGACGGCGATCGCCGCCCGGATGCGGTCCAGGACGGTGTCGGCGTCGGCTTGGGTGGGGTAGGGGCCGTGGCGGAGGGTGCGGCGGGTGCCGTCGGCGCGGGCGGGCACTTCGATCTGCCAGTGCCAGTGGCCGTGGGTGCGGGACCAGCCGCCGCCGGGCCGGCGGAGCTGGGAACAGGTGCGTCCCAGTCGCCGGCCCGTTTCGCTGTCGCGGCAGCTGCAGCGTTTGAAGGTGGATCCCTTCACTCATCGTCTCCTGGATGATTCGTATGGTGCCGCCAGCGGTGTCGGGTGGAATCCGCTGGTGGCGGGGTCGTCGCATCCACGCTCACCTTCCCGTCGGTATCAAGTCGCCCGCCCTCGTCGGTCTCGATGGGGTCGGGTTGGAGAAGGTGCAGTAGGGGGGCGACGGGGACGATGATGCGGCTGCCGGCCCGGATCAGCGGGAGCGGGAACTGGTCGGTGGCGGCGAGCCGGTATGCCTGGGATCGGCTGATCCCGAGCACCGACGCGGTGGTGGCGAGGGTGGTGGTGACGCCGAGCGCGCGGACACGCTCGACGGTCCACACCTCCCCCACGGTGGGCACAGGCGCGGTGGTGTTGTCGGTCGTGGCGTGGGTGGTCTGGTCAATGGGGTTCGAGTGGCTGTTCATGATCAGGTTTCTCCTGGCTGTGTGAAGGGTGGTCGTGCGGTACGAGCGGGGTGGTCCCGCCGACGGTGGCCGGCGTGGGGGTGCTGGCCGTGCCGCCGCCCCGCCCGTCCGGTGACAAAGGTGACAGCGGCTGGTCGGTAGGCGTGACCGGGTCGGCGAGCGGCCCGGATGGTGCCAGCGGCTCGGTCTTGAGGGTTTTGAGGAGTTCCGACAGGCGGGTGTTGGACACGGTGTGGCCGGCGGTGCGGAGGGCTTCGGCGAGCGCCGCGCGGGTCAGTGGTTGCCCGTCCGCGGCGAGCCGGTCCCGGACGCGCCGTGCCGCCGGCAGCAGCTCGGCCATGTCGCCGGACGGCTGCGCGGACCGTCCCCGGTCCGCCCGTCCGTGCTGGTCCCGTCCGCCGCGCCGACGACGAGCTTCCGGCGGGCGGACCGTCCGAGAGGTGGCCCGCTCCCCCACCGGGTCGGCGGACCGAGCGGTCTCCTCCGGTCCGCCGTCCAGGACACTCCGCGAGGTGCCGACCGGCGGACCGGCTGTCGTGGATGCGGCGTCCGTTGGCGCTGCGTCCCTGGTGTTGGTCCGGGCGAGTGCGACTTTGACCATGACGAGGAACCCGAGCGCCGGTACGGCGGCGGCGACCCAGCCGATGACAGAAGATTCGGCCTCGGCGACCTGCGCCGCCAGAGACAGCGTGACGGCGCAGGCCAGCACGGCGGCCGGGAACGCGGTTGGGGTATGGGCGCGTTTACGGCGGCGCAGTTCCAGGCCGGAGGCAATCGACATCAGCTCCAAGACGATCGCGTCGGCCCACGCCAGCCAGCCGGGCTGGCCGTGCGCTGCGGCCACGTTGTGCACGTGGGTGAAGCTGGCCGCCCCGGCCGCGCCGCCGATGGCCAGCATGATGACCACCTGGACGCCACCCTCGACGCGTCCACCGCGCAGGCCCGCGTCTCGGTCAGGAGTTGGTGTCATCGTGACCGACCACCTCCCGGACCCGGACCGCGGCGACGGCCGGTCCGCCAGCCGCGGACGAACGGCCCAGGCGGCGGACCGGTCCGGCGACCCCCACCACCCGCAACGGGGACCGAACGCGGACGGCGGACCGGGAACCGACGCCGGTCCAACCACGCGGGACGCCGGACCACGACGCCGCCCCGACGCGCCGGGACCCCACCTGCGGTGTCCCGTCTCAGTGAAGTTGCTCCGATGGGTCGGTGCTGATCTGGGTCGGAGCAGGTTGAGTGAGACGTGCAGTCCGGAACTGTCTCATCGGACTTGCCCCGCGGTCTCGTTTGCCTTGAGGTGTCTCAATGAAGGTGCCCCGGATGGCGGTTTACTTTGGCCAGCGTGGTTGGACGTCGTGGCCTTAAGCCGGGATGCGTCAGGTTGGTCGGGAGAAACGTTGAGTTGTTCTGTCGATACTTTGAGCAAGTAGGATCCATGCCGTCGTCGTGGCATGAGCCGTGCAGGAGCAGCTGATGATTTCTGATGAGACGCTCACCCGCATTAACCAGGGGGTGCAGCTGCATCATCAACAAGGCCAGCGTGAGGCTGCTCGTGACTTGTTCGCGCAGATTTGGGATGAGATCGGCGGCGAGCGAGGCGATCCCTTGCATGTTTGCGTCCTGGCGCACTCGATGGCTGATGTGCAGGACGACGTCCATCAGGAGTTGGTCTGGGACGAGCGAGCACTGGCGGCGGCCGACTTGCTCACCGATGACCGGGTTGCGCAGGCCGGGGTGCCGATGTCGGTGGCCGGTCTGTATCCGTCGTTGCATCTCAATCTGGCTGAGTGTTATCGCAAGCTCGGTGATCTCGACCGTGCCCGCGAGTGTCTCCAGCGTGCGCAGGCAGGTATCGGCGCGCTTGGCGATGACGAGTACGGAAAGTTGATCAAGGGTGGTTTGGATCGGCTGGTGGAGCAGTTGGCGGCCTCTGAGAGGGCGGTTCGAAGTTTTAGGTCCGTTTCTGGTTGAGGGCGAATACTCCGGGTTCGTCTTCAGTGAGGACGTGGCGGTTGACCATGCGTTTCAGCTTCGCGCGGGTGCCTTCGACGTTCTTGGGTGAGGGCTCGACGCCGAGTGCGAGGCAGATGCCCTTGGCGCGCATGCCGGCGGGCGCGGTGCCGAGGACATGCAGGATCTGCTGGTAGGGGCCGCTGGCGATGGTGGGGTCGTCGGCGGTGAACTCGGCGGCGGCGAGGGTGCGCAGAGTGGTGCGGGTCGTCGCCAGGTCGGCCAGTTCACCGTCGAGGCGGGCGAGTTCGCTGGTCAGGGCGGTGATCTGCTCGCGGAGCCGGTCGGCGTGCTGGCGTGTGGTGGTCTCCCGGTCGGTGATCAGGTCGAGGACGGTGGGGAGGTTCACCGGTGCCGCCAGGAGGGTGTGCTGGTTCCGGTCAGCCGCCGCACGATGTTCGCCGTCGATGCCCACAGCGTTCGGGACACCGAGGATTCTGGTCGGCTCTCGTACTCGCGCACGAGGCGGCGGTGCAGCATCAGGGTGCCGTTGACCTGCTCGACGATCCACCGCTTGCGGATCGGTACGAACCCGGGTTTGGTGTCGGATCGTTTGACGACCTCGACGTCGATGCCCAGCACGGCGCCGTGCAGGGCGAGGTCCTGCTTGAACCCGGCGTCGACCCAGGCACGGCTCACCGTCGGGGTGTGTTCGACGACCTTGTCGAGCAGCCGGATACCGATGGCGTTGTCGGTGACCGACGCCGCAGCCACCACGACCGCGATGACCAACCCCAACGCGTCCACGGCCAGGCCCCGCTTACGCCCCGACACCTTCTTCGCCGCGTCCTTGCCGGTCGTCGCGGCCGGGACGTGGTTCGCCGCCCGGATCGACTGGGTGTCCAACACCACCGCGCTCGGATCCTCCCGACGACCGACCTTCTCCCTTGCCTGGCAGCGCAGCAGATCGTGGATCACCTGGTCAGTGCCGTCGTCACGCCACAACGCGAAGTAGTAGTAGGTGGCCGACTTCGGCGGCAGGTCGTGCGGCAGGTACGCCCACTGACAGCCCGTCCGGTTCTGGTAGAAGATCGGGTTCACGATCTCCCGCAGGTCATAGTCACCCTCACGGCCCGACACCGACACCGCGACCCGCTTGGTCTTCCACGCCTGCAGGAACGGTCCAATCAGCTCCCACTGCTCGTCAGTGACATCGCTGGGATACCGCTTTCGATCACCCATGACCGGGCTAACGCCCGACCCACCCGGGCGGTCACGACCAGAACTCACATTCGGCCCATCGACCAGCCGCTATCCATAGCGAACCCGCCGGAAGACCACCAACCAGACGCAACGCATAGATCAGATCAACCTGCTGCGGACCGCCCTCTGAGCACGTAGCTCAGGCCGCTCTTGATGTCCTGAAGCACCCCACGCTGCCCCGACACCCGCGACGCGAGCAGCTCCGGCGATCGCAAGGACATCAGGAAGCCGCCGGAGAACAGATAGGAGATCGCGTCCAGCCCGACCGCGGCGGACGCCCCGACGAGCTGGACGAAACCGCCGCCGAAGCCGTTGCCCGCGATCCAGGCGGTGGAGGTGTTGAGCGAGATCGCGCTGTTGCCGGCGGTCATCTGGGGCGCCGGCAGCAGTTTCGGCACCGCCGAGGTGGAAGCCAGATCGTTGAGCACCGTCTGGATCGCCACCAGGAAGACGACGCAATACAGAATCGGCATCGAGAGCAGATCGAGCACACCCAGGATCGGGACCACGCCCAGACAGATGCCCCGGCCGAAGTCCGTGCCGACCAGGATGGCCCGTTGCGGCACCCGGTCCACCAGTGCGCCGGCCAGCAGGCTGAACAGCACGTGCGGGACGACCGTGAGCGCGGTCAGGATGCCGACCTGCGCCGCGGACGCATGCAACATCAGCGCCGCGACCATCGGAATCGCGATCGAGGTGACGCCCGTGCCGAGCGAGGAGACCAGATGCGCCGCCCACAGACGCCGGAAGTCCACCGACTCGCGCAGCACCTAGTACCAGCGAGGTCCCGTCACTTCGCTGCCCGGGTCGGCTGGGGACGAAAGGTCGGGGACTGCCACTGATTCCTCCAGGTATTGGTCCGCGGGCGGGTCGGACGGGCGTTGTTTCTCGGCGTTTGAGGGCAAGGCGCCGTCGATCGCGATCGGGGCGACCGGTGGGACGTCTACGGGATGGGCCGGACCCCGGGCCGGTACCGGGTGAGCCGGGTGAGCCGGGTGAGCCGGGTGGAATTTTCCTCGCCGTGCCCGTCCGCAACCGCATGTCGCAGGCACTCGGACACCATGGCGGTGATCGGGAGATCCGGCGCCATCCGCAGGGCGTTGCTGATGTCCTTGTGCGCCAGCTTCGCGCTGAACTGGCGAGGACGGTCGTCTTCCAAGATCTGCTGACCGAATCGCTCCAGCATGCCCAACCGCATCCGTATCGGATGCGGCAGACGGCGGTTGAGCGCCGGCGCATGTAGCAGCCAGTGGTTCTCCGAGGCGAGGATCTCCTCGATCGTGTCGGCGGTCAGGTCGGCGCGCATGGCCTTGCGGCCGAGGCCAAGCCGGTGGTGCACAAGCCGGCGGGCCGGCTCTGCCGGTAACGCGGGGTTCTCGGCGAGACCAGGCGCGGCCTGACCGTGCCGGCAGCGATCGGCCGTCGATATAGGGGCTCTTCGAAGTTGAGCGGGGTGCGCTGATCGATCCGGCCCGGAGATGAGGGCTCGCAGCCCTTGGGTGATCATCTGAGTGTCGAGTTCGGATGATCACAAGTAAAGAGCTGCGAGCATGGTCAACGATACGACCCGGCTGCTGGGCCTGGACGGCCTGGTGGTGGATCGGGTCGAGCTGCACCCGAATGGTTCCCCCATCGTCCACCTGTCCACCGGTAGCGAGCAGGCACAATGCTGCCCTCAGTGCGGTGTCCGGGCCGCCCGGGTCAAGGGCTGGGTGTTCACCTGGCCCCGGGATCTGCCGGTGGCCGGACGCACCACGCGGTTGCGGTGGCGTAAACGCCGCTGGTACTGCGATCAGCCCGGATGCCCGCGCACGTCGTTCACCGAACACGTGCCACAGATCCCGGCACGGGCACGGATCACCGTCCGGTTGCGGCAGGCGGCCGGCGCGGCGGTCGCCGACGGCAACCGAACGATCGTGCAGGCCGCCCGTGATCTGGGCATGTCCTGGCCAGTCGTCGCGGCCGCGTTCACCGCGCACACCGCAGCGGTGCTGCCGGCCGAGCCCGAACCGGTGAGCGTGCTGGGCATCGACGAGGTCCGCCGAGGCAAACCTCGCTGGATCTTCGACGAGGTCACCGCGTCGTGGACCACCATCGTCGACCGCTGGCACGTCGGCTTCTGCGATCTCGTCGGCGGGCAGGGTCTACTCGCCCAGGTCGAAGGCCGGACCAGCAAGGCGGTGACCGACTGGCTCACCCAACGCCCCGCCGCCTGGCGTCAACACGTCCAGGCCGTCGCGATCGACATGTGTACCGTGTTCAAGACCGCCGTCCGCGAGGCGCTGCCGCACGCGACGCTGGTCGTGGACCACTTCCACGTCGTCCAGCTGGCCAACCGGGCCGTCACCGAGGTCCGCCGCCGCATGACAGTCACACACCGCGGCCGGCGCGGCCGGGCCACCGACCCGGAGTGGCAGCAACGCAACCGGCTGACCAGGTCAGCAGCCCGCATGCGCGCCGAGCACGTCGACCGGCTGACCGACACCCTCAGCAACCTGCCGGCGAAGATCGGCGCACCGATCCTGACGGCCTGGAACGCCAAGGAAGACCTGCTCGACCTACTCGCACTCGCCCGCACCCACCCGAACCGGGAAACCACCGCCCGGCTGCTGCACCGCTTCTACACCCGCTGCGCCGACTCTGACCTGCCCGAACTCCACCGGCTCGCCACCACGATCGAGACCTGGTGGCCGGAAATCCTCGCGTTCCTGCACACCGGCATCACCAACGCCGGCTCCGAAGGAACCAACCGGGTCATCAAGACCGTCGCCCGCGACGCCTACGGATTCCGTAACCCCGAAAACCAGCGGCTACGCACCCGCGCCGCCACCACCCGCCGCCACCGCAGACACCTCAACCCCGCTTAA

Protein sequences of DBSCAN-SWA_3

>NZ_CP022961|5424797:5494945|5490338_5490836_+|WP_095568076.1|DBSCAN-SWA
MISDETLTRINQGVQLHHQQGQREAARDLFAQIWDEIGGERGDPLHVCVLAHSMADVQDDVHQELVWDERALAAADLLTDDRVAQAGVPMSVAGLYPSLHLNLAECYRKLGDLDRARECLQRAQAGIGALGDDEYGKLIKGGLDRLVEQLAASERAVRSFRSVSG
>NZ_CP022961|5424797:5494945|5456071_5457250_-|WP_095568074.1|DBSCAN-SWA
MRAAGPVQWIDRRDGEPFWAVLGHAAALAVLRDAARFSSAGGMRLDDNPAAVRSSANRMLIVTDPPRHAQLRRVMNAAFTPRMVARLRDTMRATVRFVLDEALERETCDLVRVAARLPVSVICDLLGVPPKDWDFMLDRTMTAFGHGNRGADPAAMAQAHTDILCYYAELVERRRREPGEDVITALVNGRVDGEPLTDEEIYLNCDGLVSGGNETSRHATVGGVRALMAHPDEWARMAGGKVPMDTAVREILRFTSPAMHVARVATADLDLEGVRIEAGQRVAVWLAAANRDPGAFDRPDVFDAGRSPNRHLALAPGEHYCLGAALAEMELTVMFEELCNRVCLPEPAGPAVRLHSNLIRGYESMPVRLRARRPRVAAPAPLSGTGRTGEPG
>NZ_CP022961|5424797:5494945|5481533_5482562_+|WP_157756914.1|DBSCAN-SWA
METTTAHGQRLRRMIQGHLLSRAVCVLADLRVPDLIGEGARDGPELARLTGTDPDALIRLLRALVAFEVLDERDDGFRLTPLGAGLRTDAPASALPSALLAHGEIGEAWQHLGTAVRTGNPSFPDLYGTDFFRYVDRNPAFRETFDRSQADGLALDDLADAVDLTCVRRIVDVGGGDGTLLAALLTGHPHLHGTLLDLAAPAHRAREQMRAAGLDGRCTVVTGDFFTSVPAGGDLYLLRQIMHDWDDARCVTLLRSCRRAMSPGARIVVSDLVLDTGPSAVPDESAALMDLYMLTVVGGRERTLAQFHDLFARAGLTVRRVTRLAGRTAAIEAVAARSAHEE
>NZ_CP022961|5424797:5494945|5493021_5493384_-|WP_157756917.1|DBSCAN-SWA
MRADLTADTIEEILASENHWLLHAPALNRRLPHPIRMRLGMLERFGQQILEDDRPRQFSAKLAHKDISNALRMAPDLPITAMVSECLRHAVADGHGEENSTRLTRLTRLTRYRPGVRPIP
>NZ_CP022961|5424797:5494945|5432976_5433522_+|WP_095566619.1|DBSCAN-SWA
MLTYLPLDPAKVVEPAMPAHHLAHAYSAYATSPFASTDVLVVDEQGSRLPEGRYERSTWCTGDSGPLWVRQRFFGSGSSLSLGMFFDVVAALVGLSEAGLPAAGKLMALAAYGRDRPWPDLVQRHPDGDTEVSLAELDHFLGEVAKVPVNHGYDDWPPSSIEDLRLKYRAIRWWLFEVKRG
>NZ_CP022961|5424797:5494945|5493628_5494945_+|WP_095566620.1|transposase|DBSCAN-SWA
MVNDTTRLLGLDGLVVDRVELHPNGSPIVHLSTGSEQAQCCPQCGVRAARVKGWVFTWPRDLPVAGRTTRLRWRKRRWYCDQPGCPRTSFTEHVPQIPARARITVRLRQAAGAAVADGNRTIVQAARDLGMSWPVVAAAFTAHTAAVLPAEPEPVSVLGIDEVRRGKPRWIFDEVTASWTTIVDRWHVGFCDLVGGQGLLAQVEGRTSKAVTDWLTQRPAAWRQHVQAVAIDMCTVFKTAVREALPHATLVVDHFHVVQLANRAVTEVRRRMTVTHRGRRGRATDPEWQQRNRLTRSAARMRAEHVDRLTDTLSNLPAKIGAPILTAWNAKEDLLDLLALARTHPNRETTARLLHRFYTRCADSDLPELHRLATTIETWWPEILAFLHTGITNAGSEGTNRVIKTVARDAYGFRNPENQRLRTRAATTRRHRRHLNPA
>NZ_CP022961|5424797:5494945|5452934_5453087_-|WP_157756912.1|DBSCAN-SWA
MLRFLRWGYEGSHRRSWTVVWTDHDAAVAAGYRVDAQRWRVLFDDLMLTV
>NZ_CP022961|5424797:5494945|5428465_5429173_+|WP_095566618.1|transposase|DBSCAN-SWA
MTVVAVRDARRSVASWCRRHTLGGEGAIAAARRGSEQVGESTVLTRRQELDLIALVRDRYPEEFGLDESGPDDELWSRHSLTEVINRRFQVSLDPTDVAGYLLAWGLGPREATDRACGLCVAEVTDWMDREYPAIVRTAREHQAELYWVGRTRIHGASPSADVLSAISTRGRTRFLLTAPSVDPSLPREFLLRLSGRDGRTVHAVVDGSWTRVEWPRRIPARIVLHPLPSCGRTT
>NZ_CP022961|5424797:5494945|5441624_5442230_+|WP_157757004.1|transposase|DBSCAN-SWA
MAGGKTVAAQRQAWLVFEDEAGQTLRPPKARTWGRRGHTPVVPVSGKGSGRVSIAGLTCYRPGERSRLIYRTITHRGRKNERRSFSERDYIALLDAAHQQLDGPIVLIWDNLNTHISAAMRQMIDARDWLHVIRLPAYAPDLNPTEAVWSHLKRSIGNLAVNGVDHLQAIIKHRLKSIQYRTDLLDGFLAHTGLTLEPDTT
>NZ_CP022961|5424797:5494945|5492182_5492848_-|WP_095566651.1|DBSCAN-SWA
MLRESVDFRRLWAAHLVSSLGTGVTSIAIPMVAALMLHASAAQVGILTALTVVPHVLFSLLAGALVDRVPQRAILVGTDFGRGICLGVVPILGVLDLLSMPILYCVVFLVAIQTVLNDLASTSAVPKLLPAPQMTAGNSAISLNTSTAWIAGNGFGGGFVQLVGASAAVGLDAISYLFSGGFLMSLRSPELLASRVSGQRGVLQDIKSGLSYVLRGRSAAG
>NZ_CP022961|5424797:5494945|5445193_5445802_+|WP_095566629.1|DBSCAN-SWA
MGDLLSALPGEGWDDTAWIEYYDGDRGLAEGFAKAGDAILVAWQRGPHPNDTVLLPLIYNYRHGIELALKQAIRQAAACICVGGNGEPELWADNLETHLKRKHGHRLAPLATQLQGLLTRLNLGDLGGESMKVLSRIHQLDPTGEAFRYSGHLNSTAYAVDVSRLAARFREAFDIIHGGVLTMLDVHQDFLYERWEYDRMWG
>NZ_CP022961|5424797:5494945|5452682_5452952_+|WP_157756911.1|DBSCAN-SWA
MADGVRPVIDSLVQPEHLIEGVQEASHDLLQRLAIATEVSGELQAYARELVQHFVEQARESGASWARIGLTMGISKQAAQKRFSSNRQH
>NZ_CP022961|5424797:5494945|5433508_5434825_-|WP_095566620.1|transposase|DBSCAN-SWA
MVNDTTRLLGLDGLVVDRVELHPNGSPIVHLSTGSEQAQCCPQCGVRAARVKGWVFTWPRDLPVAGRTTRLRWRKRRWYCDQPGCPRTSFTEHVPQIPARARITVRLRQAAGAAVADGNRTIVQAARDLGMSWPVVAAAFTAHTAAVLPAEPEPVSVLGIDEVRRGKPRWIFDEVTASWTTIVDRWHVGFCDLVGGQGLLAQVEGRTSKAVTDWLTQRPAAWRQHVQAVAIDMCTVFKTAVREALPHATLVVDHFHVVQLANRAVTEVRRRMTVTHRGRRGRATDPEWQQRNRLTRSAARMRAEHVDRLTDTLSNLPAKIGAPILTAWNAKEDLLDLLALARTHPNRETTARLLHRFYTRCADSDLPELHRLATTIETWWPEILAFLHTGITNAGSEGTNRVIKTVARDAYGFRNPENQRLRTRAATTRRHRRHLNPA
>NZ_CP022961|5424797:5494945|5448566_5448794_-|WP_157756910.1|DBSCAN-SWA
MALRSLLPGPPGGYPECRSCDWVALCGSGSPGHTHAEYGDVNHRDLFCESRQYWFERYVERQLSAVDTGPAGPRG
>NZ_CP022961|5424797:5494945|5457321_5457543_-|WP_095566637.1|DBSCAN-SWA
MTNPFEDPDGEYLVLVNEENQHSLWPSFAAVPAGWTVARAAGTHQECLDFVEQSWTDMRPRSLAESMQSPEPR
>NZ_CP022961|5424797:5494945|5446947_5447748_-|WP_095566631.1|DBSCAN-SWA
MTTTDPTEAVVLRLRAAGCVFAEDEARLLVDAARTADDLDVMTQRRVDGEPLEVILGWAEFCGLRIAVDPGVFVPRRRTAYLVEEAVAVTAEGAVVVDLCCGTGAIGAAVASRVPGIGLYAADIEPAAVRCARSNVEPIGGRVYEGDLFAALPAELRGTVGVLIVNAPYVPTDEIAMMPPEARDYEPLVALDGGFDGVEVHRRVAEHAGQWLAPGGHLLIETGESQAALTAAAMSAHGLLAHTSTSDEWYCTVAIGRRPNDCQPEG
>NZ_CP022961|5424797:5494945|5455344_5456106_+|WP_095566636.1|DBSCAN-SWA
MLADATLLIQKALAVHEGTRQPYSSTAEAVYSESETAAIMHHYLVRQAGRSPHIRYIAGFTAAGHEVSAGALEQSLLQESASMQALIDADMTARLSGTDEYFEQMLGHHVRARTVNRRLPRFAVLDGAMLLLRTDHASVPRFLIVRESHLVRSMATIFDAMFERAVDLSVAARFTGQPGEADDTENRLIRVLTMLDAGYTDETAARKLGVSVRTYRRYVAETMAQLDVSSRFQAGVRAATLNLIPAPRSVRYH
>NZ_CP022961|5424797:5494945|5486982_5488455_-|WP_095566647.1|integrase|DBSCAN-SWA
MKGSTFKRCSCRDSETGRRLGRTCSQLRRPGGGWSRTHGHWHWQIEVPARADGTRRTLRHGPYPTQADADTVLDRIRAAIAVPDPTDPHATVKTGDLIETAVKAGAPVPSPEQVRRALHLDITPTELPTMEVYLTDWLAGRRNIKAGTLRSYEGHIRLYLIPHLGHLRIDRLRPGHIDAMYDAIAERNTTIATLRASRNQARRDQVKNQRIVGNRTLHVIHATLRKALNDAMRRHRYIDTNPALMIELPTARPPKPTIWTDQRIKTWRDTGKTPSPVMIWTPEHTGRFLDHTHDAADRLYALYHLITFTGLRRGEACGLHWDDLDLDAHTLTVRWQLVQHGWTTAIDTPKTTDSEATVALDAETVAVLRAHRARQHRERLAAGAAWSKTGLVFTTPTGGRLHPADVTDHFHHLATQAGLPPIRLHDLRHGAATMGLAAGVQMKVISNRLRHSSPHFTAKFYGDVLPELSHAAAEATASVVSRKRGATKPA
>NZ_CP022961|5424797:5494945|5457564_5461389_-|WP_157756913.1|DBSCAN-SWA
MIDVLPLSPLQEGLLFQHLYHREGPDVYVTQLVLDLSGDLDRAVLRRSWDAVLTRHPHLGAAFVHEGLDRPVQILSRGVLTPWRETDLTGAGEDPDAAMTRELDADRTRRFVPAEPPLIRVLLARTGPARHRLAITSHHILMDGWSVPILVRELLTLYAAGGAPAALPPPVPYRAYLAWLAGRDTEAAATAWRAALAGVDEPTLVAADGTPPTTPRQTGTLLGAEHTDALVRLARSLGVTLSDVVQSAWAVVLGALTGRDDVVFGVVTAGRPAEIAGIEELPGLFINTVPVRVRLSPRTTLNEVPVRLRGQRLDLEPHEFLSLAEIQAAVGVGELFDTVVVFENYPSGDLGVHAGDLRLTGVHGTDATHYPLMLAVVPGDRLRLRLDHAPGQPAGAVLAALVSVLATMTAEPDRRLGHVDPFGEQGRRQLEERNDTAHPAPPTGLAGYLEQALLRFGTDVAVIDGDRRLTYAELDRRSAALAAELARRGAGPERTVGLHVSRSAGLVVALLAIVRSGAAYLPLDPQYPVGRLRYMIDEARPALVLTDGEPPGGAPALHLADVPAARRAPAPTDDPASLASIIFTSGSTGAPKGVAGTRAGLLNRLAWFAELQPFTGNEALLAKSSISFIDGTVELLQTLAHGGRVVMADDAAAADMTALADLVARHDVRVLTAVPSLLLALLDEAAAGPPGRLSSLRLVLSSGEPMPAELPARLLVESPDARLVNFCGCTEVSSESVFALCDVHDRAIGTPLWNNRAYVLDGALRPVRTGVAGDLYYGGAGVGRGYVRRPGATAERFVADPFGPPGARMFRTGDRVACRQDGKLIHLGRSDGQLKVRGVRIEPGEVEAALARHPTTAAAAVAVRRPPGGDPVLVGYVTPAPGAVPDPADLRRYVATLLPPALVPSVLVVLDRLPRTPNGKVDRRGLPDPGPGTTGVSAPAGPREQVLCELFEEVLGLPAVGPADDFFGLGGHSLLATRLIARIRSALGTEVTLRSLFETPTPAGLAARLGDTGRDPLDVLLPLRDVSGRPPLFCFHPAGGFSWCYTGLLRQLPADQPLFGLQARGLTDPARVADSADEMVTEYVRRIRAMGAPGPYSLLGWSLGGQLAHAAAARLQAEGARPGLLVMLDSYPPETLPETPALDRPEILRLVLREYFGVEPPTGAVLDTAAATALLRAAGVADLSEAHVEAVARILPAASTAARAYRPPVFDGDLLFFRATRGWSGPPPDPRAWQPYVSGGIEIHEVDTTHGRMTRPAELARISAVLRPRLPGTA
>NZ_CP022961|5424797:5494945|5488451_5488862_-|WP_095566648.1|DBSCAN-SWA
MNSHSNPIDQTTHATTDNTTAPVPTVGEVWTVERVRALGVTTTLATTASVLGISRSQAYRLAATDQFPLPLIRAGSRIIVPVAPLLHLLQPDPIETDEGGRLDTDGKVSVDATTPPPADSTRHRWRHHTNHPGDDE
>NZ_CP022961|5424797:5494945|5479039_5480296_+|WP_095566642.1|DBSCAN-SWA
MTHSVGPDAGPDLAIASDDPPRPPTGVGDGRALGAWLDVMRASHPVWRDPLTGSAHVFRYHDLLHVLSTPEVYGSDFTGVMPPSDPSAPNFAEGVLTMIDPPRHGKLRRLVSQAFTPRVITALEPRIIQLTKELLDTVADQDEFDLVAVMAHPLPVIVIAEMLGIPAEDRELFRAWGEALLSTNYELETGEVPDNSALPPDVVAQLTEMRDYLLRHVDLHRRDPRDNLTSRLAFAEVDGDRLTDQEIVSFLNFLLLAGHLTTSLLMGNSLLCFAEAPEAEAAARANRALIPGAIEEVLRFKPPVVMQARLTVVDTVLAGVELPARTPVMGWPMSGNRDERQYRSPSTFDITRNPNPHLTFGHGIHFCIGAPLGRMEARSVLNELFDRYRSIEIGEPRYYDRSPDVFGVKALPVTVKHS
>NZ_CP022961|5424797:5494945|5429308_5429872_+|WP_095568071.1|DBSCAN-SWA
MLAGDPYRADDPDLVERMLRAAELTAAFGAVPARDLRQRRALLADLLGAIGADTQIRPPLRVDYGDQIRIGARVFVNFGLVALDAAPITIGDSVQIGPNVQLLTATHPVDPPSRRDGWEAARPIAIGDNAWLGGGAIVLAGVTIGHDTVVGAGAVVTRDLPAGVVAVGNPARIIRTGLPAPQRPPER
>NZ_CP022961|5424797:5494945|5477494_5478811_-|WP_095566641.1|DBSCAN-SWA
MYRTIESGSRFRAFGPRQLDEIVRRYPMAAEVRDTVRMFSRVLPFRINEYVLDELIDWSRVPADPMFQLVFPQPGMLSDEHAAALRALDGRADADPGVTAVVRRIRAELNPHPGGQLDLNVPRRDGVAIPGLQHKYRETVLYFPSQGQTCHAYCTYCFRWAQFVGDADLRFAAPGPDALVRYLREHPEVNDVLVTGGDPAVMSADRLRGHLRPLLAVPTLRVIRMGTKAPAYWPQRFVTDPDADDLLRLFAEVVESGRTMAVMAHFSHDREIASPMAEKAISRIRSTGAVIYCQAPLIAHVNDDPDVWTSLWRAQIAAGCVPYYLFVARDTGPHDYFRVPLQRAAEIFAEAYRRLPGLARTVRGPVMSTEAGKVVVDGADGGVFQLRFLQARNPDLVGCPFRADGSPDAAWITELTPRPDTPADLRHALAHPQTEVTA
>NZ_CP022961|5424797:5494945|5483319_5484501_-|WP_157756915.1|DBSCAN-SWA
MPSHFLFISIPDPGRLSPHLAIGKELVRRGHSVKFVTVEPMAALVGSYGVEPLVYGSAYGSIPVHEEKEMSAEAAMLALSVDDSAAMIDAVEAAYGDERPDLIAYDVASGTAGRVLARKWGLPAAQLYADFAQNDEFAYTQPFDDDGVALGEPLSPAGWAARSELKPWVDRTERLLTAHGLTDVTFAELLEVVQEFNLVYVPKALQPAADSFDDRFRFVGPCVGEQPARDDWQPPADGLPVVLVPSAPQGADLARAFVGAPVHVVLTPGPGADPASLSELPPNVEVHASLPQGVLRHAAVVVSQGDVGNVTEALAAGRPVVVVPPALPARITGFQLAKLGLGRLAAPDGLRDAVLDLIGDRAVAERLAWMRGEIEAAGGVPRAADELEAHAAR
>NZ_CP022961|5424797:5494945|5491220_5492057_-|WP_095566650.1|transposase|DBSCAN-SWA
MGDRKRYPSDVTDEQWELIGPFLQAWKTKRVAVSVSGREGDYDLREIVNPIFYQNRTGCQWAYLPHDLPPKSATYYYFALWRDDGTDQVIHDLLRCQAREKVGRREDPSAVVLDTQSIRAANHVPAATTGKDAAKKVSGRKRGLAVDALGLVIAVVVAAASVTDNAIGIRLLDKVVEHTPTVSRAWVDAGFKQDLALHGAVLGIDVEVVKRSDTKPGFVPIRKRWIVEQVNGTLMLHRRLVREYESRPESSVSRTLWASTANIVRRLTGTSTPSWRHR
>NZ_CP022961|5424797:5494945|5435280_5436258_+|WP_157756903.1|DBSCAN-SWA
MNRYGLGQVSRQVTPADIANLIAGGSIVCWFDGASEWGPRALGGRSILADPLRDGVVVELNRRVKFREPFRPFGLSVAEDALAELIDIAQAPATLAPYMLAVGRIRDDRLSAIVHRDGTVRYQSVTCDYGPYHQLLMALRNRIGLAAVLNTSFNTMGEPLVETPDDAVRQFLLCGADALYLDGALVEADDLPLDTLAAAREQAWSGRGVDLLRLALQQEAAGYPDAAQETATRLTPCRSDGPGRIRESAALMMRLAELAGADETAVERAEEVLQWSGLPPAAGDAARLLTEVSAQGRAIGPDAARFLAAIAPPGRASAIVARMLS
>NZ_CP022961|5424797:5494945|5446576_5446882_-|WP_157756909.1|DBSCAN-SWA
MPHPEHYVRQIIGKLNEDPGNTALISRGEPVRVPENHRAAIRVREDRLIDGVTLFFNRHVLGPIGSRSRKPACPRRTTSSATNTLKPRPSSAGSSPALTAA
>NZ_CP022961|5424797:5494945|5437491_5438310_+|WP_157756904.1|DBSCAN-SWA
MPRASVHHTSIPELRGIEFDHRTARWELSWRNDLGQTTTRAADSLPDLVASIDRNPIVAASSEPMDTVRAGEPILLAPGVAGILLHELIGHAAEQGDLSVGTRVLPPGTDLRSLPARPDLDDEGVPVQAHDLVVDGEYAIPVHDRASGGPPSGDAWCAAHGVAPKARLIRLTVTSYIPGRSTSDGLVHVLRSTGGAYFHGFAMVNVALARRGTRPIAAVRLGVSIADLARGQWGPAGQVQIADGVCVKDGEALPSIIASPPLILEGASLWPA
>NZ_CP022961|5424797:5494945|5424797_5426456_-|WP_095566614.1|tRNA|DBSCAN-SWA
MTPAKLAQVVLDAARAVFTTRGLDHSLLPATATVERPRNPEHGDYASTLALQLGKRAGVAPRELAGALAEELGRAPGIKSVEIAGPGFLNIRIEASAAGQLAREIVEAGSGYGRSTRLAGQRVNLEFVSANPTGPVHLGHTRWAAVGDSQRRILAAAGAEVTSEHYVNDAGAQVDRFGRSLYAAAHGEPVPEDGYVGEYVAQIARRLVEARPDVLDLAPEQAQTVFRDEGYRLMLDEMRASLERFGVHFDVWFSERTLHESGAVEHALDELRAQGHVYERDGAIWLRTTDFTDDKDRVLIRSNGEKTYFAADAAYYINKRERGFDKCVYLLGADHHGYVNRLRAIAACAGDDPDYNIEILIGQLVNLVRAGVPVRLSKRAGNIITLDEIVEAVGVDAARYSLARSSTDSPLTLDIEEITRRSNDNPVFYVQYAHARISSLLRNAGELRIDRGSEFDPGLLRHEKENTLLKKLGEFPAVVATAAELREPHRVARYLEQLAGDYHRFYDACRVLPQGDEPATDLTRARLWLVEATRVVLANGLDLLGVSAPERM
>NZ_CP022961|5424797:5494945|5440599_5441127_+|WP_157756906.1|DBSCAN-SWA
MHGLVAHDEGHVPVVDLGIAGSRSRALLAQTVAEICATAGFFVALGHGVLTDVVAAMDDATAAFFHQPTRDKLALLAEPGDPLARGLGRDGSLAGPNVSASAIDRAADDVLETYTMNRLGEPEHAEDLPARVDPVMRTPNKWPDLPGFRSAYTAYYAAMEQLQILNGQVRPMWSV
>NZ_CP022961|5424797:5494945|5454545_5455067_-|WP_095566635.1|DBSCAN-SWA
MDGGPAWGAAPTAVHVAIVRQLACDVGARLLDPLDRLLGTDRHDMPVSSVLRRRLEIAAEVWAAQVLGPDERLAAETVRRLVAEIYQSGDVFAPPFEWWRTPFGALVARRFGHPAAEAVSLTVASAMLGITRQGVHDLVRRGKLRRDKASGGVLVSSVRDRLAQLSEAFGHER
>NZ_CP022961|5424797:5494945|5484683_5486222_+|WP_157756916.1|DBSCAN-SWA
MSQPAVRQPAKPIDRKRWSILAAICFALVMVVIDNTVLNIAIPTLMTELSTTAAEAQWAFTSYLLVLSGFVLVGGVASDRYGRKRIVLVGIALFGTASLAAALATEPWQLIAARAAMGFGAALLMPGTLAILMHTFSDAERPKAIGAWMAVAAVGSSGGPILGGFLISHFWWGAVFLINVPISILCLVALVILVPDVPATRNDRIDWIGAVLSVIATVSLVWAITSVPEHGWASAAVEVPAMIGVLALAAFIACELRVESPMLDLGLFRNLRFSAAVLGGLLASFGMAGSLFLLTLHFQLLNGYTPIEASIRLLPLAICTLIGSTAISVIVLKRLGAPLALLASMAVAAIGLLLIGLLPAEDYLSSLAGLILVGLGTGSAGPVAGTVLMSSIPLEKAGAGSGVSSTIQELGNGLGVAVLGTVLTAFFVNRLPGSLRAEGESSFTDAIGRASGAAADQVRDAFATGLSFSQIIGALTVLGGGLAASALLWMTRSAATPQMPPADQLSTPAAKL
>NZ_CP022961|5424797:5494945|5427598_5428273_+|WP_095566617.1|DBSCAN-SWA
MTISTDPVLRDDLGGPPAPPAGAPADRRYGLLALTLAVVVGLLIGYVGGWLTPQLGAPGDNSPEAGFARDMSVHHAQAVEMGMIAFQSAATPGVRIMGGDIATGQQAQIGIMQTWLKEWRLEPTGSEPAMAWMPEGVAALRDGLMPGMATPEQMAQLRAARGTQVDVLFCELMITHHLGGIHMVDGILDQTHDRRVVEIAEAMKATQQTDINNLTDLLAKAKAG
>NZ_CP022961|5424797:5494945|5446075_5446504_-|WP_157756908.1|DBSCAN-SWA
MAELEQEFAQAEARLRQHVAATPPEEEQDAGLLEHLPQLGVDLNRLPPERLRRFLEAFRVEIHYDGRTGRATFKAEISAKTTTELAQLARLAEATRGQQIRSADYTESSDRVIPATPDGQQMIKGSRFGLCTQPVSIRTLNL
>NZ_CP022961|5424797:5494945|5448780_5451216_-|WP_095566633.1|DBSCAN-SWA
MDVKPTEEQLAARDTFLAGRELALVAGAGTGKTSTLVLMAGVTRKRGLYVAFNKAIADEARQRFGANVDCRTAHSLAHRAVGRNYQERLNRSARIPSKETARLLSIHQNLWVSSRPITCGHQARLVMGMIRRFCYSTDRQLMARHLEPVNGLDPAAQDHVARVLLPYACRAWDDICSPDGKLRFEHDHYLKMWALTEPTLAADFVLLDEAQDTNPVLEEVFLAQNAQRVCVGDPAQQIYAWRNARDVMTGFPADHLYLTKSFRFGPRIARTANRWLRHAESDLQLTGNSATDSRVGSAAEIDAVLCRGNADAMQEVLGFLERGVPVALTGGGGALRNIAQAAQALKSGRRTSHPELFLFTSWADVQEYAENDTAGQDLKAIVTLVDTYGPDVIIDAVDRLSEERTAEVTVSTAHKAKGREWSRVRIGDGFAAPSVDDDGMPRPLRAGEARLIYVAVTRARHHLDPAGINWIDDYEKATEAAGDGTVAGRPMIELSLTRQLRYPNSPMSQFVAQHLPNSAAVVQDYLRRICELPRPVQPLDVKYPDWSALGHAIDFRLRLCLGSPFGAPVDIGVDAVGSGLPLRGAPAPPVRDALHRAGRDLISMADAYLHGDDDLDGEILGRLCFVAAYYEDIYRTGEVRRYSMLTGATPATTLDDLLTAVPDYAIEDVNRQLAIAEESFGPFLELPATARVCGPTFVGSQDIGGADADFILDGLLLDCKAAIQPRRLGRDEIYQLASYLLLDYDDRYSIDRVGLYLSRQGALVTWSVPDFLRRLGATGPVGHLRRRLREHLLRRSGDRLATSPQSDVGAA
>NZ_CP022961|5424797:5494945|5488836_5489760_-|WP_095568075.1|DBSCAN-SWA
MLAIGGAAGAASFTHVHNVAAAHGQPGWLAWADAIVLELMSIASGLELRRRKRAHTPTAFPAAVLACAVTLSLAAQVAEAESSVIGWVAAAVPALGFLVMVKVALARTNTRDAAPTDAASTTAGPPVGTSRSVLDGGPEETARSADPVGERATSRTVRPPEARRRRGGRDQHGRADRGRSAQPSGDMAELLPAARRVRDRLAADGQPLTRAALAEALRTAGHTVSNTRLSELLKTLKTEPLAPSGPLADPVTPTDQPLSPLSPDGRGGGTASTPTPATVGGTTPLVPHDHPSHSQEKPDHEQPLEPH
>NZ_CP022961|5424797:5494945|5480303_5481527_+|WP_095566643.1|DBSCAN-SWA
MTSASHDEALQAGPPPVVGDGRALYDWLRRARDAGPVWHDTANDAYHVLRHDEVVGVLSEPLIFSSDFSSLAPPPEPGMPNFTEASLSVTDPPMHTQLRKIISQAFTPRMIAGLEPRITALATDLLDAIEGRDTIEMVQDLAAPLPVVVIAEMLGIPSDDWATFRRWAEYLLPDAADVTAGQFEEGGYAKTRAAELNEMADYLLAHVHDRRRSPKDDLFTRLVEATADGDRLTDKQVVNFSVFLLLAGHLTTTLTLTNAVLAFNDSPGTLERVRADRSLVPGALEEVLRFRPPVSFLYRFTTQDAVIAGTPVPPGKIVVNWIHSVNRDPRRFVEPDRFDPGRSPNPHLTFSHGIHYCLGVPLARLEFSVVFGAILNRYRALECGTPEFHQRPDIFGVTRLPVTLHAA
>NZ_CP022961|5424797:5494945|5430060_5431023_+|WP_095568072.1|DBSCAN-SWA
MDAAGTLLARRHARHLDRSPLLPAHFTEPAAATAAVHRACAGQDASGSIATRGGEAVGYLLGAPKSTEVWGPNIWVESAGQATIEAETIRDLYAVAATRWVDEGRTAHYALAPATDPELIGAWFRLGFGHQHTHAIRPVPASRTDPPATSTATATATATATTVRRATRDDIETLARLDLELPRHQALAPVFSAGPVPTLEECLDDWATDIDNPEYAAFVAVRDGEVIGSAIGCPLEKSSSHTGLARPERAGFLGFAAVFPQARGAGAGRALGEAVLDWTRTAGFSCAVTDWRATNLLSSRAWPALGFTDSFLRLHRVVGY
>NZ_CP022961|5424797:5494945|5426561_5427575_+|WP_095566616.1|DBSCAN-SWA
MSISTPGGDPRRPIVVTRKKAVAGGKPATDDEPATPVEDGESGPDAAADEAGSGAATSADAKSAKPSKPVPGARPAPGAKSAANRAGQSRPGGKRPTDGKRPTGGSRPAGGGKGRKPIAPVKVSQGRAWGPIALGTAVGVLAVAIVGYGAWAVYQGGRSWQDKADSISGILDVRKTDPESLKYEKHQAGPINYTKYQPPVGGVHNDVWQNCMGDVYDAPIASEHAVHSLEHGAVWITYRPDLPQDQVDKLAEKVRGQSYMLMSPYEGLDKPISLQAWGFQLKVDKAGDGRIDDFIKALRVNAAAEPGASCSQGITATGTTPHDLPGGGDANAGGMGG
>NZ_CP022961|5424797:5494945|5436254_5437241_+|WP_095566622.1|DBSCAN-SWA
MTSLPADVLLVTGPDEARQVLDDDRTFRAARMEEYVPGVSRSFFLATDVSDPESGARCREALAAFLAPDRLRALHRDLIAPAAAGRVAKLAAEFRATPDYLRSYGRQVSYALAGIDAADGPAMVAKVRLAGTLLAEDRRSADGRALINDVKRQLRSMALHSGFAPDGLPGLALARRLATVDEAVLLALPLLEMAAFDMNTSLAAAALRRTAQLSPAEQRELLDPAQLRRLVWEAAADLTDLLATRVATCPMTVGATPVAPGDRVVVDLHAANQTGLDHLSFGRGRHACMGRELAMTIGIAPVKAILRRGWIAAQTGGDLVVRIHPWAA
>NZ_CP022961|5424797:5494945|5453425_5454535_-|WP_095568073.1|DBSCAN-SWA
MALTGLLPEFSEDDWSRRAAAVLEADRIVEKATPLIRLSFPGESLAAMFVKDESARPTGSVKYRFARSLFRHALSRGVIRRGVQLVEATSGNMAVAEAHFARVLGLPFTAVVPGKSSPDRIARIVAQGGTAYRVDPPLAVYENAERLAGRSNGYYLDCLSTLGPAIDADLDDGVPGLPDEILRDFAAQGRPEPAWIVTGAGTGATSRAIGRYLRRHGHATRLAVVDAENSAYFPGWATECRDYATGMPSRIEGIGRPRMEPAFDPDVVDLVIPVPDVSSVAAMRFLATAGGVAAGPSTGACLWGACHLVNRMSQAGESGAVVIVAADGAEPYRRSYYDDEWVAGKRWDLTEPTLRLERFMRTGDWDDSR
>NZ_CP022961|5424797:5494945|5447856_5448570_-|WP_095566632.1|DBSCAN-SWA
MTTPWETRIADIVDGWLFDEKIELPEVLLVPLENPHLFDAGGWAALGPVRASSGVVAVHEYQGTRVGVAKPVLGAAGCAMLVDAASRRGVRTVLGVGYCGGTHPTLRSGDVVAATSAVTGDGVSALYQPGQDLVPASERLITALGTLNGDRSRLRTGPVHSVGAVHLETQSLVDDCAAAGAASAGDPHPSARPGRLRTARRRRRGAAGRRPRTGRRQDRGTTPGAGPGPAAAAGRLG
>NZ_CP022961|5424797:5494945|5439277_5440597_+|WP_157756905.1|DBSCAN-SWA
MDVEMASHRWRHFIMESPEATVSVAAGPGTSRRRHSPILAAFATSAIGDGLRLAALPLLAVTITTNPVAIAGLAVAGRLPWLLVALLSGVAADRYNRMNLMILVDIMRGLVVCGLVVFIVTDATSIVTLYVVALALGVGETIFESATQGLLPEVIDGNRLPAANGQLYMANLFGTTFAGPPLGSWLFGIGRAIPFLTDAATFLLSAALLGAYRLKHGYNRRVQEQPADRGSVLVEVGEGFRWIRRHPLIRTFLAVSTVANFTQSLVQSLLVLLATRHLGLSESAFGLLLTASGVGAFLGGSLSAWVGIRLGVHRVLLPAVALCLPLFLVMAWTDNSVVLGAALAVNAFLGVLVGVQMSALRQRIVPNQVLGRVSSVSQFFSFGVAIPVGAFLAGLIADWFGIAAVYLFAAAVIVVLLAAVTNQLMPGRVRHAVEALQGA
>NZ_CP022961|5424797:5494945|5442686_5443994_+|WP_157756907.1|DBSCAN-SWA
MNNRELATFILLGAAAAAFLWSRSGREASPSLARQLFASRITPFLVVFAGIVVGVTWLAERLSLWTTDLLGSVVLWFLLVGFVWFINLGDANKDPDFFKRRFFETLGLTALLEFFINAQVMPLPLELVAQVILLIVVILNVIAASDEKYKPAAKLTSGILFFATMGLLTYSVAHLVSGWDSLDKRGLLNELLMPIWLTAATIPVLYLFAFYMAYESLFVRLSFFNNRRKPSLRARLGIVTGIRGALVDIQQFRGGPAHDAAQARTTSDARAAVRRFKEERALDRAARAAARQALVDNAGRKGTDGDGLLLDRREFAETKDALRWLATCHMGWYRNADRPDEYRADLLDVLSGSRQFEFESGEPVVAKVRKDRQAWYAYRRTPSGHVFGIGASGPPPSQWFYDAPTLPSGYPSTTSIGWTDFMSPDRPEWRLEPER
>NZ_CP022961|5424797:5494945|5490816_5491224_-|WP_095566649.1|DBSCAN-SWA
MNLPTVLDLITDRETTTRQHADRLREQITALTSELARLDGELADLATTRTTLRTLAAAEFTADDPTIASGPYQQILHVLGTAPAGMRAKGICLALGVEPSPKNVEGTRAKLKRMVNRHVLTEDEPGVFALNQKRT
>NZ_CP022961|5424797:5494945|5461400_5472140_-|WP_095566639.1|DBSCAN-SWA
MPAGLGARAEVIRTGTSRFDLTVSLDEEPDAGLRGVIEYAADLFDPASVALLGERLVRVLDTAVRDPEVRVGDITLLSPAERARILDEWNGGPLGTAPGTTVQQRFAETAARTPDAVAIRAADGDTWTYRRLDEAAAVLAARLRDAGVRPGDRVAVLVERSPALIAATLAVLRLGAAYVPLNPGDPPRRREFVLDRAGVTALLVDTAHQEAGGRPVVRIGDPASSIPQPVRLHTGRPDDLAYVMFTSGSTGEPKGIGVTHANVLSLAGDRHWDDGHERVLVHSPYAFDASTYEMWVPLLRGGQCVLAPSGTTDSLRLAGLLESRAVTAVFLTTALFNHLIEERPAALAGVRQIWFGGELVSPSTVRRAVRSCPRTRVVHVYGPTETTTFAYAGVVTDVPDDAETVPIGRTLDGDCGYVLDARLRPVPPNVTGELYLAGHGVARGYLGRPGLTASRFLACPFGAPGGRMYRTGDLVRLRTDGELEFVGRDDDQVKIRGHRIELGEIQSVLAEDPAVAEAFVTVVRDPAVGRRLVAYLVPAAGNPIDTGRVRAAARARLPEFMVPGLWAVLPELPLSVNGKVDRSRLPEVTGEAAVGGRGPRSVREELICGVFADVLGVPRVGIDDDFFELGGHSLLATQVVSRIRSLLGLELRIQDLFAVRTPAGLADRLNTADRPALGRHAREGTVPLSFAQRRLWFVHRLEGEGATYNVPLALRLSGAVDVQALSAAVNDLVCRHEPLRSTVEGREDGPAMVVSPPAAGLVRLDVREVDEDDLPGVLHEAVRYPFDLSAMFPVRASLFSVSATEHVFLLLVHHIAADGWSLRPLLTDLATAYEARRAGRAPAWAPLPVEYADYTSWQRDLLGDPDDPASVARAQLAHWRDTLAGMPEQLTLPADRPRPAINTFVGDVLPVHLDAGLHAELLDLARRTHTTLFMVVQAAFAVLLTHSGAGTDLPIGAPIAGRTDEKLEGLVGFFVNTLVLRTDTSGDPTFRELLHRVRATALDAYAHQDLPFDLLVEHLNPERSLSHQALFQVLVVLQNAPAADYSLPGLRVEPVDTTPGVSKFDLSLSLNEAYAPDGRPRGLDGYLEYSTAMFDADTVDRLATRLDRLLRGFATDPDRRIGALSLIDDSERRLMLETWNATGRAVPEAASVPELFTRQARLRPDAPAILSHAGRLTYRELDERSDRLAYLLRGRGVGPGRIVALALHRGPDLVTAMLAVGKTGAAYLPVDPAYPQARIAYLLDDARPTLLVTTRASELGRPADLFLDDPEIVAELAAAPAGPGGVAVPPDAPAYVLYTSGSTGRPKGVVVSHRGAAPLAEAQRAWFGAGPGSRVLQFASPSFDAAFWELVMALLTGATLVTVPAARLLPGDPLSATAAEFGVTHLTLPPSALVALGDRDLPSVTTLVVAGEACPPDLVRRWSRGRTMFNAYGPTETTVCATISSPLTGDGVPPIGRPVHGMRVYVLDARLRPVPPGVTGELYVAGPGLADAYLHRPGLTAERFVACPFGAPGDRMYRTGDLARWSADGTLGFAGRADDQVKVRGYRIEPGEVEAMLSAHPRVRAAAVTVRDQGLIGYLVPAPDAPSGGEAAQVDAWRDVFRSQYEETGADAGFGEDFSGWHSALDGAPIPLPDMREWRAETVAAIRRLRPRRVLEIGVGSGLLLAPLAPDCETYWGTDLSGEAIEGLRRHVVARPGLRDRVRLHPVPADAIDTLPGAGFDTIILNSVVQYFPSAEYLTDVLEKAVRLLAPGGAIYLGDLRDPRAARALYAAVAAVRLGQDADPGEAAVLAERLAAEERELLVAPEFLIGLAGTSGVDIRVKRGRRDNELTRYRYEAVLYTAPTVPIDLGDVPGLSWDRDKVVDGLADAPDRLRITGVPGDRREHVVAAGRRHGYLTVVTWAEDRDVCEAVLVAGAADGTPVTGAYRPGDGDGPWTNVPARASRHATLQAEVREYLRARLPEFMVPGLLMVLDELPLSVNGKVDRSRLPAARVAAPAGNRGPRSVREELVCGVFADVLGVPRVGIDDDFFELGGHSLLATQVVSRIRGLLGLTVSLQDLFDARTPAGLTGRLGTADRVALGRRTREGMVPLSFAQRRLWFVHRLEGASATYNVPLLLRLSGEVDAEALGTAVNDVVCRHEPLRSTVVERDGEPFMVVTPPGPGLVRLAVGEGDPGHAFDLATEFPIRAWLSRRSATEHVLLLLIHHIAADGWSLRPLLADLALAYEARRAGRAPVQPPLPVEYTDYAAWQRDLLGDTGDPDSTAGAQLSYWRETLAGMPQRLALPTDHPRPLELGYAGATHRFVIGPDLHARLLELAGETRSTLFMVVQAAFAVLLSRLGAGTDIPIGTAVAGRSDEKLDDLVGFFVNTLVLRTDVSGDPSFRELVGRVRGTDLAAFAHQDLPFERLVDAVGADRAAGNNPLFNVMLALDNNAGLDLRLPGLRTSPEPLPSGIARFDLTLGLSERVLGDFGTDGVECSLEYRTELFRPATVEALAVRLLMILRQIVVKPDVAVSALEILTPDEQVWTATGGGAAPDPGSPHTVASLFEARVAADPDAIVAVAGSVTRTAAELNRAANRLARLLMARGAGPETVVAVRLPRGIALVEALLAIAKAGAAYLPIDPGYPAARIAYMIEDAAPVLVLARAAAADTHPVLDLDDPGVCAELRAADDTDPRVRSHPDHPAYVIYTSGSTGRPKGVEVPHRGVVNLVAGSRERLGRLGEDTRMLQSASPSFDTAYWEMCVTLLAGGRVVLPRTDAWNVAEDLAPLVAAHAVSHLAVPPSVLAAFPDDALPDGTTIVIGGEPCPPYLLQRWAGRCRVLNAYGPTETTIAATVGGPLTPEGGAPIGTPLRGVRLRLLDERLCPVPVGVPAELYLAGPGVARGYRHQPRATAERFVADPFGPPGSRMYRTGDLVRLRADGQLDFVGRADEQVKVRGYRIEPAEIEGVLQEHPAVGQAAVTVHRGTAQHIVGYVVAVDGPPDPAELRAIAARSLPGHMVPDLIMFLEELPRSPNGKLDRAALPKPEFAPAGPGRTPRTPAETALREAFAELLGVAGVGIDDDFFALGGDSVGAIRLSGRARRAGLVLTPGDVFRHRTVAGLAAVATPAPALPAVAHDDGTGSLPLTPVMHWLRELGGPTAHFHQSALISVPADTGQEQLDRMLCALTDRHDALRLRRRNWTLEVRPAGAAPIAVERVDVHGLPDARRAEVLAEETGRVVGGMDPDEGRTAVAVWFDAGPDEPGRLFLAVHHLAIDGVSWRILLEDLAGSTAAVPPVATSFRRWAHLLTEEARRPERVAELPYWAGVLDGAALPPELTPVPDRDTTGTLRHLTVELGPDVAEPLLGTVPDAFRCGTEDLVLTALALAVRSRTAFGAAADAGLVVELENHGRGTIAGTDVSRTVGWFTSTYPVRLDAGPGRDPADAVKRIKEQVRATPGDGLGFGLLRYLNAGTSARLAALPAPRIAVNYLGVFRIGEPVDWGLDALGGAADPELPVAHTLALNVVAEDRPGGRILRATWTWPAALLTEDAVRSLAGAWQDRARSLAELGADDGGFTPSDLHLAGLDQAQIDHLESMWRSPR
>NZ_CP022961|5424797:5494945|5472106_5476222_-|WP_095566640.1|DBSCAN-SWA
MFDTGERWPLTAAQLGSYYGHELDPTGWGYNQASYLEIHGPIRVTEFIAAVRTAVRETEALHTRFRADADGPAQYLTASAETPVPVVDLRSAAVPIAEAETWMRAELSRPVDLSTGPTHAQALLRVGDERYLWYQRYHHAVLDGYGVWLLTRRAAEVYDALLAGRDVGPALGSLRDLLAEDASYLNSAAPEDDRRHWTGLLSPVPAPILLGGRSAPAQPEFVLHRTDLGVPVLDGLRARADRLSIRWSRLAVATVASWVGALTGRTDLVLTLPVTGRTTPVARAVPGMLANMQPMRLRIAEGAGLDDLAGQVDRWIRGAAAHQRYPYERLSRELRGGADRPKLFGPIVNVLSFAAEPAFGGRAAVRHWIAIGPVDDLEVMLQESATGGLQLKLWANGGVYDEASVARHAADVAQRLADAAAGARLSGPGPESPGPTGTAWAHFAAAADARPDLLALVDDAAGGDVVTYRDLRADAERLGTVLARRGAGAETVIALMLPRGRALVTAMLATWHAGAAFLPVDPSYPADRIEFMLADAHPLLVLTDQAYESAGPPVIRLDELDLEAEAVTAARTCASGNPAYVIYTSGSTGRPKGVVVTHAGVGDLVATQRDRLGAGPGARVLQFASPSFDASFWETAMGLLAGATLVVAAQDRLRPGDELAALAGAHGVTHLTVPPSALSAMGEATLPGVSTLLVAGEAIGEAIAGRWAPGRRMMNAYGPTETTVCATISTPLAGDGPPPLGTPVRGTAVHVLDDALRPVRPGAVGELYVSGNSLARGYAGRPGLTASRFLACPFGAPGGRMYRTGDLVRLRTDGELEFVGRDDDQVKIRGHRVEPGEVQAVLGRHPDVAQIVAVARYDALVAYVVPASAAGRDTTSLKAFAAARLPEYLVPDAFVVLGELPLLPNGKVDRAALPAPGTDRVAPAAPQDRHQTDLERNLCRLFADVLRVPQVGPDDSFFDLGGHSLLATRLIIRLRAELGVEVSIQELFDLRTPGGLAERLDAIDRGGLRRRDRDGGVPLSFAQRRLWFVDRLAGAGATYNVPLALRFDGDVDAGALGAAVNDVVCRHEPLRSTVAERDGEPYLVVTPPGPGLVEIVAGRGAPEDAVGYAFDLASELPIRALFFDGRVLLLLMHHIATDGWSVGPLLRDLAIAYAARRAGRAPVWEPLPVEYADYALWQRDLAGEEDGAWAADLDHWRAALDGLPPAIALPADRSRPAVRDQAGGNHGFVIGAELHARLVELARATRSTPFMVVQAALAVLLCRSGAGTDVPIGTAVAGRTDEKLDDLVGFFVNTVVLRTDLGGDPTFRELIGRVRAADLAAFAHQDLPFERLVEDLNPERSLSHQPLFQVMLVLNNTPAPPCRPASARAPR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095566614.1|5424797_5426456_-|tRNA	arginine--tRNA ligase	NA	NA	NA	NA
WP_095566616.1|5426561_5427575_+	DUF3105 domain-containing protein	NA	NA	NA	NA
WP_095566617.1|5427598_5428273_+	DUF305 domain-containing protein	NA	NA	NA	NA
WP_095566618.1|5428465_5429173_+|transposase	transposase	NA	NA	NA	NA
WP_095568071.1|5429308_5429872_+	sugar O-acetyltransferase	NA	NA	NA	NA
WP_095568072.1|5430060_5431023_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_095566619.1|5432976_5433522_+	hypothetical protein	NA	NA	NA	NA
5433497:5433556	attL	NA	NA	NA	NA
WP_095566620.1|5433508_5434825_-|transposase	ISL3 family transposase	Q6V7R1	Burkholderia_virus	2.8e-08	25.9
WP_157756903.1|5435280_5436258_+	hypothetical protein	E3SL71	Synechococcus_phage	3.0e-23	37.1
WP_095566622.1|5436254_5437241_+	hypothetical protein	NA	NA	NA	NA
WP_157756904.1|5437491_5438310_+	hypothetical protein	NA	NA	NA	NA
WP_157756905.1|5439277_5440597_+	MFS transporter	NA	NA	NA	NA
WP_157756906.1|5440599_5441127_+	hypothetical protein	NA	NA	NA	NA
WP_157757004.1|5441624_5442230_+|transposase	IS630 family transposase	NA	NA	NA	NA
WP_157756907.1|5442686_5443994_+	hypothetical protein	NA	NA	NA	NA
WP_095566629.1|5445193_5445802_+	hypothetical protein	NA	NA	NA	NA
WP_157756908.1|5446075_5446504_-	hypothetical protein	NA	NA	NA	NA
WP_157756909.1|5446576_5446882_-	hypothetical protein	NA	NA	NA	NA
WP_095566631.1|5446947_5447748_-	putative protein N(5)-glutamine methyltransferase	NA	NA	NA	NA
WP_095566632.1|5447856_5448570_-	hypothetical protein	NA	NA	NA	NA
WP_157756910.1|5448566_5448794_-	hypothetical protein	NA	NA	NA	NA
WP_095566633.1|5448780_5451216_-	ATP-dependent helicase	V5JX97	Pseudomonas_phage	3.1e-37	28.4
WP_157756911.1|5452682_5452952_+	hypothetical protein	NA	NA	NA	NA
WP_157756912.1|5452934_5453087_-	hypothetical protein	NA	NA	NA	NA
WP_095568073.1|5453425_5454535_-	pyridoxal-phosphate dependent enzyme	NA	NA	NA	NA
WP_095566635.1|5454545_5455067_-	hypothetical protein	NA	NA	NA	NA
WP_095566636.1|5455344_5456106_+	hypothetical protein	NA	NA	NA	NA
WP_095568074.1|5456071_5457250_-	cytochrome P450	NA	NA	NA	NA
WP_095566637.1|5457321_5457543_-	MbtH family protein	NA	NA	NA	NA
WP_157756913.1|5457564_5461389_-	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	9.2e-52	23.7
WP_095566639.1|5461400_5472140_-	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	1.6e-109	23.6
WP_095566640.1|5472106_5476222_-	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	8.9e-53	27.7
WP_095566641.1|5477494_5478811_-	lysine 2,3-aminomutase	NA	NA	NA	NA
WP_095566642.1|5479039_5480296_+	cytochrome P450	NA	NA	NA	NA
WP_095566643.1|5480303_5481527_+	cytochrome P450	NA	NA	NA	NA
WP_157756914.1|5481533_5482562_+	methyltransferase	NA	NA	NA	NA
WP_157756915.1|5483319_5484501_-	glycosyl transferase	NA	NA	NA	NA
WP_157756916.1|5484683_5486222_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_095566647.1|5486982_5488455_-|integrase	site-specific integrase	S5MBZ0	Brevibacillus_phage	3.7e-25	28.7
WP_095566648.1|5488451_5488862_-	hypothetical protein	A0A142K9K9	Gordonia_phage	3.6e-07	54.2
WP_095568075.1|5488836_5489760_-	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_095568076.1|5490338_5490836_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_095566649.1|5490816_5491224_-	hypothetical protein	NA	NA	NA	NA
WP_095566650.1|5491220_5492057_-|transposase	IS5 family transposase	NA	NA	NA	NA
WP_095566651.1|5492182_5492848_-	MFS transporter	NA	NA	NA	NA
WP_157756917.1|5493021_5493384_-	hypothetical protein	NA	NA	NA	NA
WP_095566620.1|5493628_5494945_+|transposase	ISL3 family transposase	Q6V7R1	Burkholderia_virus	2.8e-08	25.9
5494898:5496346	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NZ_CP022961|5919606:5970478|DBSCAN-SWA
GTCATGCGGCCTTGAAGGGGTAATCCGGGTGGCGGATCTTGGACTTGGTCGCGTATCCCGTTTTCGGGCGGGCCTGCTGGTTGTGCCAGCGGATGTAGTCACCGATCGCGGCGTCCTGCTCGGCGTGGGTGCGGTGGTCGGTGCCGTTGAGGGTGAAGTAGCGCAAAGCGGCGAACTCGGCTTCGATCCAGTTCAGCCAGGAGCTGTAGGTCGGCAGGAAGACCAGCTCAACGTCGTTGGCCTGGCACCAGGCCCGCACGGTGGGGTGCTTGTGTGGGGAGAAGTTGTCCAGGATCAGGTGCAGCGTCTGCCCTGGCCAGCGGCGCCGCAGGCTCTTGAGGAAGTCGAGGAACTCGCTCGATCGTTTCCGGTCCCGGATCCGGTAGTGGATTCGTCCGGTGGCCAGGTCGAGGCTGGCGATCATGTGCCGGACACCGTGGTCACGGTGGTACGTCGCCCGGAGTCGGACCGGTTTGCCCTGCGGTTTCCAGGCTTTGCCCGGCCGGGGCTGCAGGTTCAGCGGCCCGAACTCGTCGACGCAGATGACCCGGCCGCCGGCCGGTGGATGGTCGTAGAGGTCGAGGACCCGGCGCATCTTGGCGGTGAAGTCCGGGTCGTTGCTGGCCTTCCACGTCTTCGACGTCTGCCAGGTGACGCCGCGTTCGTGCAGGATCCGCCGGACGGTCTCGATGCTGATCGTGTCCACCTGGCCGGTGGCGATCAGGTAGTCACGCAGCTTGGACAGCGACCAGGTCGTAAACGGCTGGCCGAGGAAGCGGGGGTCACACCGGGCGATCACGCAGATCCAGTCGCGGGTCTGCTCATTGATCTTGTTCGGTGTGCCCCCTGTCCATTTTGGGTCCAGCGCGTCGAACCCCCGCTCGTTGAACGCGTGGACCACGTCGCGGACGTAGTCCTCGGTGGCCTTGAGCAGGTACGCGATGTCGGGCACCGGCTGGCCCTGGCCAGACATCAGAACCACGATCGCCCGGCGCAGCTTGACCGGGTTCTTCGCGGTCCGCGTGATCTTCTGCAGCCGCTGGCCCTCGGCCATCGACAGCGCCCGCACGAACACTTCCGGGCGTCGTCCCACCCGGCATCACCTCCCACACCAACAGCGAGAGGGACAGCCTGCCCGAAACGGCCCCCGAACCAACGGATTACACGGCCAACGTCCAAAGACGAGGCACTAGACGGTTGCGTTCTGTTAGCGTGACGTGCATCGTTGTCGCTACGGGAGGGGCGTCGTGATCGATCCGACGTCAGAGATGCAACGCCTCGCGGGAAAGTTCGCCCTGCTCCTCGCTGGCATCTACGTGCTGTTCCCGTTCGGAATGGCCGTGTCCACCGCCGCCGGCGAACCCATCCCCCTGTGGGGGTGGCCGCTGCTCTTGCTACCGGCGTTCCTGTTCGCCCCTGCCGTGATCGCCGCGATACGGCTGCATCGCACCTCCGACCGGGACATCGGCAAGCGCCTCTGGTGGCGCAGCCTGCTGCTGGCTTGTACCGGTTTTGTGCTGGTTATCGCGGTCGCGCTCATCCTCGGCGAGGCAAACTCGTGACCTTCACCGTCCACCCCGAGGCACTGCGGACCTACGCCGCCCAGCTCGACGAGGCCCGACAAGCCGCCGAAGAGGCCAAGCGATACATCACCCATCATGGCTCCTTCAGCCTGCACGACAGCGGCCTGTTCGGTAAGGCGGCTCCCGGACACCGGCACGTCATGGCCGCGCTGGACCTGCTGCTTGACCGCCTCGCCCGGCTTACCGATACCTCCAGCTTGGCCCTGCTTCAAGTCGCAGCCGGCTACGAACGCACCGACGACCAGGCTGCGGCGAGGATCGACGCCAGCTACCCGGCCGTACCCCGGCCCGCCCCCAACCGCGACTAGTGCCTCGTCTTTGGACGTTGGCGGTGTAATCCGTTGGTTCGGGGGCCGTTTCGGGCAGGCTGTCCCTCTCGCTGTTGGTGTGGGAGGTGATGCCGGGTGGGACGACGCCCGGAAGTGTTCGTGCGGGCGCTGTCGATGGCCGAGGGCCAGCGGCTGCAGAAGATCACGCGGACCGCGAAGAACCCGGTCAAGCTGCGCCGGGCGATCGTGGTTCTGATGTCTGGCCAGGGCCAGCCGGTGCCCGACATCGCGTACCTGCTCAAGGCCACCGAGGACTACGTCCGCGACGTGGTCCACGCGTTCAACGAGCGGGGGTTCGACGCGCTGGACCCAAAATGGACAGGGGGCACACCGAACAAGATCAATGAGCAGACCCGCGACTGGATCTGCGTGATCGCCCGGTGTGACCCCCGCTTCCTCGGCCAGCCGTTTACGACCTGGTCGCTGTCCAAGCTGCGTGACTACCTGATCGCCACCGGCCAGGTGGACACGATCAGCATCGAGACCGTCCGGCGGATCCTGCACGAACGCGGCGTCACCTGGCAGACGTCGAAGACGTGGAAGGCCAGCAACGACCCGGACTTCACCGCCAAGATGCGCCGGGTCCTCGACCTCTACGACCATCCACCGGCCGGCGGCCGGGTCATCTGCGTCGACGAGTTCGGGCCGCTGAACCTGCAGCCCCGGCCGGGCAAAGCCTGGAAACCGCAGGGCAAACCGGTCCGACTCCGGGCGACGTACCACCGTGACCACGGTGTCCGGCACATGATCGCCAGCCTCGACCTGGCCACCGGACGAATCCACTACCGGATCCGGGACCGGAAACGATCGAGCGAGTTCCTCGACTTCCTCAAGAGCCTGCGGCGCCGCTGGCCAGGGCAGACGCTGCACCTGATCCTGGACAACTTCTCCCCACACAAGCACCCCACCGTGCGGGCCTGGTGCCAGGCCAACGACGTTGAGCTGGTCTTCCTGCCGACCTACAGCTCCTGGCTGAACTGGATCGAAGCCGAGTTCGCCGCTTTGCGCTACTTCACCCTCAACGGCACCGACCACCGCACCCACGCCGAGCAGGACGCCGCGATCGGTGACTACATCCGCTGGCACAACCAGCAGGCCCGCCCGAAAACGGGATACGCGACCAAGTCCAAGATCCGCCACCCGGATTACCCCTTCAAGGCCGCATGACGAGGCACTAGGTCACCCGGCCGGAGGTTGCTTCCATGAACGACGCGACCATTTTTCTGGTCGAGCCCGGCGAACCCGAAGCCAGCATCAGCCAGGGATTCGCCAACCCGCTGGACCTTTTCAACTACCTCAGCCCGTCAGCGTGGATCAACTCTGCCATCGCTGACCTCACCGGCACCGACGTCTTCGGCTGGATGACCGACTGGATCGGCGGCGACTGGGCCGCGATGTGGAAGTTCGGCGACGCCCTCGGCCACCTTGCCGAATGCCTGCAGCAGATCGGCATCAACATCCAGGCCGGCGTCATTGCCCTTGACGCCTCCTGGGACGGCAATGCCAACGACGCCGCCTACCGATACTTCTCCCACCTGGCCAGCAGCGTCAGCGGCCAGCAGTACGCCCTGACCGACCTGCGCGATCGGTACCACAAAGCCGCCACGGGCGCCTGGCAGATGTCCAACCAACTCGGCAACATCCTGCAAGCCCTGGCCGACAAAGCCATCCTCGCCGGCATCGCCGCCGCGGCCGGCACCATCACCGCCGAGACCGGCATCGGCGCCCTCGCCGGCTACGGCACGGCAGCGCTGATCGTGACCGACATGCTCAAACTCATCAACCAGGCATCCATCATCATCAACACCGCCGGAACAGCCATCCTCAGCTTCTTCGGCATCGCCATCGATCTCATCTACCAAGGAGGCGGAGGCCTTGGATCCATCCCCCTACCCGCCGTCTCATACACCCCACCCGCAGCCTGACATGCCCCGAGACCGCCTCGACCACGACCTGGAGGAGATGACCGGAGACCCAGCAATCGCCCGCGACATCAAAAAGACCCTCCGCCAGCTCGCCGACGGAACCGGCGGACCCACGCTCGCCGAACTCGCCCGCAACGTCCTGGACGGCCGCACGACCCTCCGCTCCGCCGCGTCCAGCGACGCCTACGCCACCCCGCTCACCGACGCCATCAACCAGTTCCGCCAGTGGCACGAGCAGTTGCCCCCCGAGCAGCGCCGGCAGATTCTCGATGACACCCGCCGACGCCTACACCAGGCAACCGACAACACCGCCTAACCGACGCGACCACCGACAGCACCGATTAGGAGCCACATGGCCTCACCCAAACGGCAACGTCACCGCGAACGACGAGCGGTCGGCGAACCCGCGCCCGACCTTCCACCGGCCACCGTCCGTCCGACGCGAAGGCGAGCGTGCAAGCGATGCGGCGAAGGCGGCCGAACCGAGAAACCCCCTACGGCTGGGTATGCGCCGACTGCCCTTCCCCTCGTAGCGTGGAGGCCAGAGCTTGAGGGATAGAGGTTCATGGCTGAGACGAGACGCCAGTTCGATCCGGAGTTCCGGGCGGGCGTTTCTCCTGCGTATCGAGGTGCCCCCGGCAGGATTCGAACCTGCGACACACGGTTTAGGAAACCGATGCTCTATCCCCTGAGCTACGAGGGCGCGAGGGCCCAGTCTAGCGACCTGGGGGTTCACCTGGGGTGGCAGGGAGTGGCCCACGTTCACCCACGTTCCCCGGACCCCTGTTCGCCCAGCCCAGGACCACAGCCGGAGTCTCCATGTGACTCCGGTTGATCTTGGTGGGCAGGGTGGATCGACCGGCGCATGGGGTTGCGTCGGCGGGGAGCGGTTTGGTTCAGGCTGCCGCGCGGATCACCGGTGCCGGTCGAGTGAATGAGCCATTCCGTGCAAGGTTCTGACTACTGAGGGTTGTCATGTAGTGCGGTCGTGCTCGATGTGGAGAACGGCCAACGCGGCGGCGACGATCTTGCCGATCCGCCATGGGTTGAGGCTGACGTTGCGCAGCGCCTTGAAGGTCATCTTGAGCAGCGAGTTGCCGCGTTCGGCGATCGCTCGCAGGCTGTTGTGGGCCTTGTTGAGCTGCTGCTGGACGAGGCTGAGCTTGGCGTTCTTCGGCTTCTTGAACGCGACGGTGATGGTGCCGGACTCGCCCTCGTAGCCCAGATCGCCGAGGGTGCGCAGGTCGGAGCCGGCGGCGGTGAGGGCGGGCAGGATCTCGGCGTGGGTGCGGACGGCGGTGGTGTCGTGTTCGCGGCCGGGCCGCACACCGGAGGTCCAGATCGGCCAGCCGTCGGGCACGGTGACGACCTGGACGTTGCCGCCGTGGTTGTCGTGTTTACCGGACCACCACAGGTCGACGCCCTCCGTAGGGCCCGGGGTGCGGCACCGGTCGGTCTCGACCAGAATCCCGTCGATGTTCACGTAGTCATGGCCGGCGGCCTTCGCCGCGAGTAGGGCGCCGTGCAGGGTCGGTGACCGGGCGGCGAGAACATCGATGCCTTCGTGGAGGTAGTCGTAGCTGGTGGAGAGGCTGATCGCGTTGTCCCGGGCGAGTTGCCGCATCCGCGTGCTGTCGAGGAACCAGCGCAGGATCAGGACCGCCTGGTCACGGCATGGCAGAGCGCGGGTTCCGGCACGGGTACCGCGGCGGGCGCGTTCCGTGGTGAGCAGACCGGCGAGTACGTCCACGGTGTGTTCGCGTACCGGCAGGACAGCGGTGTATGTGACACTCATCGTCGGCGCAGGACCTCTATGAAGTTGAGCTGTAGGAGGCCACCTTCTTATCGAGGTTCTGCGCCGTTCCTACGTAGCCGCGATCATCCGGCGCGTCTCCGACTTTCCACGCATCTCGTCGGCTACAGACAGCAACCGCAACGTTGCACGGAATGGCTCACTGGCCTGGCTGCTGCACAATCTCGTCGAGAAGCCAGCCATGCGCCGGTGGTCGCGGCCCCGGCCCAAGGTGGTGGCACCCGCCGCCCCGGCCGACCGAATATCTGCAGAACGACAGATTTCCTCGACGACTTCAAATGTTACCGATGCCAGCCGATGATCGCCTCACATAGGCTGTCCGCATGGGAAGCGGATCGCTCGCAGCATGGCGCGACAGGCACTCATGGGCCGCCGTTCTGGCCCTCCTGGTTCTCGCTCCGGCGATCATCGCGCCCCCCGTTGGATTGATCGTTGCCATTCCTGCCGCGACCGCGGTGGCCGTGGTGTTCATCAGATGGCCGCAGCGCGGAATCTCGATGATCACCGCGGCCACCGCGGTATCGGCGATATCGCTCACGGTCGACATCGCCTACCCCGGGCCGCCCGGGCTCGCACTGTTCTGGCTGCCATTCGAGATGCTGGCTCTGTTGCTTCTGACCGGCATGACGATCCGGCTTGCCGGCGAGCGCAAGGCTCTCGTGAGTGGTGCGCCGTGCGTGCTCACGACGATCCTGCTGCCCCTACGGTTCACGCTGCGGATGGACCAGTCCGTGCTCAGCGGATCGATCATCATGATCGCACTGACCGTCTTTCCCACGGCCATAGCGATCGGCATCGGGTTCTATCTGCGCGGCCAGGACCACAAGCGTCGCCAGGCCGTTAGTACCGCCCGCCGCGACCAGCGGCTGCGGGTCGCCGGTGACCTGCACGACTTCGTGGCCCACGAGGTCACCGGCATCGTGCTCGAGGCACAGGCGGCCCAGCTCGAGCCGCTCGACGCCGAGCGGGCTCGGGCGATCTTCTCGCACATCGAGGTCGCGGGGCTGCGGGCGCTGGAGTCCATGGACCAGACCGTGCGGACCCTGCGTGACCCGAACGGCGACAGCAGCGAGGACGCCCCTCCGGTGCGGGTGTACCGCCTGGCCGACCTGCCCGCGCTGGTCGACCGGTTCTCCTCCGGCACGGCCATGACGGCGACCCTCGACCTGCCGGCCGAGCTGATCCACGCCCTCGACCCGGAGCGGGAGGCCGCGGCGTACGCGGTGGTGCTGGAAGCCCTGACCAACGTGCGGCGACACGCACCCCGCGCCGCCGAGGTACGCGTCGTGCTGCGCCCGCTCCCCGGCCCCGAACTCGAGGTCCTGGTCGACAACGATGGCCGGTCCGGAAGCGGCCTGGTCGGCAGTCGCACCGGCGGAGGCACCGGGCTGATCGGCATCGAGGAGCGGGTCCGCGCCCTGGGCGGGCACCTGAGCGCGGGCCACACGGACAGCGGCTGGCAGGTGCGCTGCGCCTTCCCGGCGCCGATCTTGGCCGTGACCGCGCCGGAGCCGCCGACGTTGGCTCTGCCGCCAGGGCAGCCGGGGCCATACACCGCCTGGAAGTGACGACGCACGAGGGGTTCCCCGGCCCGGCCGCCGCCTGACTGATTCCGGGGCCTGAGCCGGATCTTCGACCGGACCCCCTCGACCCGCCCAGTGGCGTCCTCCCGCCGCTACGGCCGGGCATTCGGGCCGTTCGCCGCCGGCTCGTTCCTTGTTTCCGCTGGCCACAGATCTGCCGAACGGCAGATGTCTCTCCTCTTCCGGATCGCCATGATGAAGCAGTCAGCAGATATTGCGATCGGAGGACTTGATCATGCCCCCCAAGGGAAAGGGACTCCTCGTTGCCACCCTTGTTGCCGCCATTACTTCCGGCGCCGCCGGATGCGGCAACAGCGAGGCGACGAAAACCGAATCTCAGAGCTTTCCCCTTCCCGGAGAGGTTCTCCGCATCGACGCGTCCGAGGCCGCGGTGAAGGTGATCAGCGGCACCGGCGAATCAGTCGACGTGCAGCGCGAACTGAAGGGCAAGGCGACTGACGACGGCAACGCCACGTGGACGATGTCGGGCGACACGCTCAAGCTCGGGCTGCGCTGCTCGGGCATCGTGGTCAGCTGCGAGGGCAGGTACACGGTCGCCGTGCCGCAGGGAACGGCCCTGCGGGTCAACGCCTCCGGCAGTGCCGTGACCCTGGACTCTCTCACCGGCGACATCGACGCCTCGGTCACCGACGACGGAACGCTGCGCGTGGCGGGGCCGACCGGGAAACTGAGCCTGGCCACCCGGGGCGGCTCCATCACCGTCACGAGCGCGCGATCCACCGAGGTGACCGCACAGACCAAGGGCGACGGCAACATCGACCTCGGCTTCCTCATGGCGCCCGAGCGGGTGAAGGCGACCGCCAGCGGTTCGGTCCAGGTGACTCTCCCGAACGACTCCGGGACGTACCGGATTGTCGGCGCCGACTCCGCGAGTCTCGCCTCCGACGACAAGAGCTCCCGTTCCATCACCGTCTCCGCCGCAGACGGTACCGCCAGCGTCCAACGAGCCGGCTAGGAGACCGTGCCATGCTCGAACTGATCGACATCACCAAGATCTACGCCGGGGACAAGCGGGCCGTCGACAGCATGACGCTCCGGATGGACGCCGGCATGCTCGGCATGCTCGGCCCGAACGGCGCCGGGAAGTCCTCGCTCATGCGGATCGCGGCCACCGTCACCAAGCCCACGTCCGGGCGGGTGCTCTTCAACGGCGACGACGTCGTGGCCCGGCCCGACCTGCTGCGCCGGACACTCGGGTACCTACCGCAGGACTTCGGCGTCTACCCCAACCTCACCTCGCGCGAGTTCCTGGGCTACCTGGCCGCCGCCAAGGGCCTCTCGGCCCGGTCGGCCAAGGCCCGCATCGACGAGCTGCTCGCGATGGTCAACCTCACCGAGGCACTGAAGCGACCGCTGGGCAAGTACTCCGGCGGCATGCTCCGGCGGGTCGGCATCGCGCAGGCGCTGCTCGCCGACCCTCAGGTGATCATCGTGGACGAGCCGACCGCGGGCCTCGACCCCGAGGAGCGGGTCCGCTTCCGCAACCTGCTCAGCGACCTCGCGGCCGATCGGGTCGTCATGCTTTCGACCCATATCGTGTCCGATGTGGAGTCGGTCGCGTCCGACATCGCGATCGTCGCGCAGGGGCGGCTGCTGCGCCGGGACAGCCCGGAGGAGTTGCTGCGCCAGGTCGACGGGCAGGTCTGGGAGGTCGTAGTGCCCTCCGATCGGGTGTCGGTTCTACAGCACCAGTACGTCATCAGCCGCCTGGTCCGCACCACCGCAGGCGTCCGGGTCCGGCTGCTCTCCCCCGTGCAGCCGGGCCCGGACTCGACCCGTGTCGCGCCCGACCTCGAGGACGCCTACCTGGCCGTCATCAACTTCGCGGCCGGGCGGTCCGTCGACCCGGCGCGGGCGGTACGGCGATGATCGCCCGGGACATCACCGCCCTGGCGGTTGCCGACTTCCGTGACCGGATACGCCGGCCCGCGTACGTGGTGATCCTGGTGGCTGCCGTGGCCCTGGGTTACTTCGCGGCACCGGATTCCGACGCCCGCTGGGTCGTCATGTACATCGGCACCCACCGCGGCGTCTACAACTCGGCCTACATGGGTACCCTGATCGCCCTGGCCAGCGCCCTCTGGCTGACCCTGGGTGGGTTCTACGTCGTGCGCAACGGTGTCAGCCGGGACGAGAGCACCGGCGTCGGCCAGCTCTTCGCCGCCACGCCGATGCGCACGGTCAGTTATCTGACCGGGAAATTCCTCAGCAACTGCCTGGTGCTCAGCTCAATGGTCGGCGTGCTCGCGGTTACCGCGCTGATCCTGCAGCTGGCCCGCGGCGAGGAGATGTCGATCGACCCGGTCGACCTGCTCCTGCCCTTCCTGATCATCGCCCTTCCGCTGGTAGCGTTCACCGCCGGCATGGCCCTGCTGTTCGAGACCGTCCCGCTGCTCAAGGGCGGTCTGGGCAACATCTTGTGGTTCGTGGTCTGGCTCGCGGTCGCGATCGGCGGCCAGTCACCGGACGCCCCACTCGGTGGTATCGGGGTGCACGCGGTCGCGGCCTCCATGGCGCAGAGCATGTCCGCTCAGGGCGTCGACATCTCCGAGGGTGGCTTCAGCCTCGGCCTAGTCTATCTGGACAACCCGCTGCGCACGTTCGTCTGGGACGGCCTCGACGTCACCGCCGGATACCTGTTCGGCCGGCTCGCCATGGTGCTGATCTCGCTGCTGCTCGCGCTCGTGCCGGTGTGGTGGTTCGCGCGCTTCGACCCGTCGCGTCGGCACGGTACGGCGTCGGCGCCGGCCGGTGGCCCGGCCGCCCCGGGGACCGGGATGCCGGACGGCACGCCGGCCGGACCGGGGGAACTCGCCGTCGGCGGCGTCGCGGTGCTCGCCCGCCCCCAGGCCGTCGCGCCGGCAGCCGGGCTACCTCGCTCGGTGCCGAAACAGGGCGGCGCGTACGGCCGGCTGTTGGCCGGCGAGTTCCGGATCCTGATCCAGGGCGTCTCCCGCTGGTGGTGGCTGGGCATGGCGCTCATCATCATCGCCGGCCTGGCGCTGCCGATCGGTGCCGTGACGCTGTTCGCCCTGCCCATCGCGTGGATCTGGCCGGTCCTGATCTGGTCCCGGCTCGGCACTCAGCGCTACGAGTACGGTGTGGACGGCATCCTGGGCGCCTACCCGTGGGTGCGGCGGCGCCTCGTCGCCGAGTGGGGCGCGGGCGTCCTGCTCACTGCGGTCACCGGCGGCGCGCCCCTGATCCGGATGGTGGCCGCGGCCGACAACGCCGGGGTGGCCGCCTGGTGCGCCGGCGCGCTCTTCATTCCCTCCCTGGCGCTGGCCCTGGGCGTGCTGAGCCGCACGCAACGCCTCTTCCAGGCCGTCTACCTGCTCTGGTGGTACGTCATTATCAACGGCATCGCATTCCTGGACTTCATGGGCACCGTGCGCAGCGACGGCGAGCCGGCCGGGCCGAGCCCGTTCCTCATCGCCGCGGTCGCGCTGGTCCTGGTGGCCGTGACCTTCGCGGCGGGCACGCTGCGCCGCAACGCACGATCATGAGGACCGTCCCGGTGACCGGAGGACGGGTGACACACATCGGTGAGGCACTGGCGGGAGGAGCGTTCGAGTTGCCGGCTGGAGACGAGGAGCGGGGAGACGAGCCGTCGCGCTCCGAGCGGCGCGCAGTACCCTCCGACGACCAGGACGCGCTCGAGGAGCACCGCATCGCGCGGCTCGAGCGCGAGGTCGAGGAGCTTCGCAACGCCAACGAGATCTTGCTCCGGGTCGCCGGGTTCCTGATCCGGCCGCGGGACCGGCCGCAGACCGGCGAGGACCACGACTGAGGTCTCCCGACAGGGCTTCGCGGCCGCCGGCCGGTCAGCTTCGGGCTGGCTCCGGCGGCCGCCGCGTCGTGTCCGGGATATGCCATGATGAGCGGGATGGGAATCCGAGTTCTGATCGCCGACGACCAAGCGATGGTTCGCCAGGGCATGCGGCGCATCCTGGAAAGTCAGTCCGACATCTCGGTGGTCGGTGAGGCGGCTGACGGTGTGGCAGCCGTGGAGCTGGTGCAGAGCCTGCGACCCGACGTGCTCCTAGTCGACATCCGGATGCCGCGGATGGACGGCCTGGAAGTGACCCGCCTGGTGGCTGGCTCCGCGGCGACCAGGTCCGTCAAGGTCGTCGTGGTGACCACGTTCGACCTCGACGAGTACGTTTACCCGGCATTGCGCTACGGCGCCTCGGGCTTCCTGCTCAAACGGTCCGGAGCGGTTCTCATCATCGAGGCGGTACGGGCAGCGGTGGCCGGCGACAGCATGATCAGTCCGTCGATCACGGTGCGCCTGCTGAAGCACGTCACCCAGCCGTCACCGGCGCTGCCCGCGCCGACCGAGTCGCTGACCGCCCGCGAGGTGGAGATTGCCGGACAGGTCGCGCAGGGCAAGACGAACGCCGACATCGCCGCCGAGCTGTTCATCTCGCCCGGCACGGTGAAGACCCACGTCGCGGCCATCCAGCGCAAACTCAACGTGCGCAACCGCGTCGGCGTGGCCGTGTACGCGTGGGAAGCCGGTTACGCCAGCCAGCCTTCCACCGATTGATCTTGGCAATATCTGCCGATCGGTAGATGCCCCTTCGCCGACCGCGGTCGATGCTCGAGGAACGAGCTTCGATGCGTCGGGAGGACCCGTGAGACCGCGCAAGACGATGGCGCTCATTCTGGCCGCTGCGGCCGCCGTGCCAACCATGGCCGGCTGCGAGGAGAAGGCGAAGTCCGGACCAGAACAGTCCGAGTCACGATCGTTCAACCTGTCCGGCACCACACTCAAGGTCGTCGCGACCGAAGCCGCGGTGCAGATCAAGGCGGGTGCCGGCGGCGGCATCGACGTCAAGCGCTCGGTGCGCGGCGAGATCGCCGACGGCGACTCGGCCATGTCGCTCGACGACGGGACGCTTCACCTCAGGGCCACCTGCGGCGGAGTGGTTAAGGACTGCTCGGCGAAGTACACGGTAACCGTCCCGAAAGGCGTCTCGCTGAACCTGGACGGCGTCGGCAGCGACGTCACGGTCACCGGTCTGCGCAACGGGCTGACCGCGCGGCTGAGCGCGGACGCGTCGCTCAGCGCCAACGACATCGCCGGCACGATGCAACTCCGCAGCGACGGCGGTGACATCACGGTGAAGCGGGCGCGGGCCGACACCGTCAAGGCGGTGGCGTCCAACGACGGCAACGTGCGGCTCTCCTTCGCCGAACCACCCAGATCCGTCGAGGCCAAGTCCTACGGCGGAGCGGTGACCGTGGTCGTCCCGACCGGCTCGGCCACGTATCGGGTGGTCACCGCCGGAAACAGTGTCGGCAAGCAACTGGAGTCCGATCCGCGCAGCAGCCGGACCATCTCCGCCGTGGCCACCGACGGCCCGGTCTCCGTTCGGAAGGGTTGAGCCGCCGCATTTGTCAACTCGTTTCCGCAGCGGCTTTCGATTAGGTCGGCGGTTGACACGCCCACCGGGCCCGGCAGACTGACAGCGATCACTACTTTACGGGGAGTAGCGTGATTTCGATACCTCCTGCCGCGCGTCGGGGTAAGCCCTTTTCACGATGCCGAGGTGTTTCCTTTGGCCGTTAGTCCGAGTCTTACTGGCCTGCGCTGGCAATTCGGGATACCCATCCGCGCACAACGGGGCGCGGAGCCGGCTTTACCAATGGGGGGCGTCGATGCGGATTCACCTCGAACTGGAGGACCTCACGCGAGTGCGCATGGTCGAGAGCGCCTCGCCGGTGCTGGAGAGCATCTTCGCGCTGCAGATGCTGAGCGGTCCCACCAACCCGGTCTTCCGCGACTGGCGGCGGCAGGCCGAGGTGGCCGTCGGTCGCCGACTGAACGACGTGACCGAGTTGCTGCGCCGCCACCAGCCGGTGCCCGACCTGCTCTGGCTGGCCGACCGGGAGACCAAAATCCCTGCTCACGGCTACTTTGCGCACCAGGGGGCACGGCAGCGGGCGGTTCCGGTCGTGTTCGACTTCTGCCGGCTCGCGGTCCTGCCGTACTGGAGTTCGCTGCGTCGATACCTCCAGTCCTACCGCGAGGCCCGCGGACAGCACGTCATTCAGCGGGGCGTCGACAGCCTCCTGCGCACGCTGCATCCGCTGTTGAGCTGGGAGCCACCCGTGCTCACCATTCCCGACGGCCGCGATCGTGACGTCTATTTGTCCGGGCGAGGACTTTCCTTCAAGATGTCGTTGTTCCTGGGAACTACTCCGGGCTTAGTCATGGATCCGGATGCCGGCGGCAGCGTCCAATTGGTGGTGCCCGTGCCGGTGACCGGGGAGACAGCGTCGGTTCTGCGCGCCCCGTCGGAGGACGAAGAAGGCGCACTCGGTGCGCTTGTCGGGCATACCCGGGCGGCCGCTCTGCAGGTGATGGCCGACGGTTGCACGACCGGCGAACTGTCCGACCGTCTGGGCATTTCGCTGGCCGGCGCCAGCAAACACGCGAAGGTTCTCCGGAAAGCGGGCCTCATCGTGACGGCCCGCAATGGGAACAGCAGTTTGCATTCACTTAGCTCACTCGGACTTGCATTGCTGAAAGCCGTCACGACGCGAGCGTCTAAGCCTCGATCCACCGATGAAGGTCGACTCGACGGGGCCCTGGATATAGGAAGTGCCCTGTCGGGTGGCCGGAGGGAGTCTCACCCTCCGGCTCCCACAGATCCCGGCGTGAACCTCTCGGCTCACCGGGCTCTTGTCATCCTGATCACCAGACGGTGGAGAGCGAGGTGACCCATCTCCAGTGGGCGAACAGGCTCCGTCGCTTCTCGACGGTTCGTCGCCAGTGCTGGAGGGCCTTCTTCTTGCTCCGCAGCCGTTTGAGCTTCCGACGGAGGAAGCGCATCAGGTAGGCGTTGATGCGTTCCAGGAGCGGGTGCAGTTTGGAGCGGTAGAACGCTCCGTAGTACTGCATCCAACCCCGCACGATCGGGTTGATCCAGCGCGCGAGATCGGCAAGGGTCAAGTTCGTCTTGTAGTGCAGCTTCCACGAGCGCACCGTCGCGTTCATCTTCATCTGGGCCGCGTCGCTGCGCGCCGGTAGGAACCCGTTGAAGGTCTGGCCCCGCCGGTTACGTGCTCCACGCTGCCGAAATGTGAAACCGAGGAACGTGAACGATGTGTGCTCATACGAGCCTCGCCGGTTGCTGTCCTGGCAGTAGACGATCCGGGTCTTGTCCGGATGCAGTTGCAGGCCCACCTGCCGCATCCGCTCGGCGATCGCGTCCCGCACCTGGACGGCACGGGCCTCGGTGCGACAGTGCACCACCGCGTCGTCGACGTAGCGGGCGAACTCGACGTCCGGGAACGTCCGTGCCAGCCACGCATCCAGCGCGTAGTGCAGAAACAGGTTCGCCAGCGCGGGTGATACCGCAGAACCCTGCGGGGTTCCCCGCTCCCGACGGATCACGGTCCCGTCCGCGGTGACCATCGGCGCGGCCAGCCACCGCTTCACATACAAGATGATCCACGGCTGGTCGGTGTTGGCCTCCACGGCTTTGACCACGAGATCCCACGGGACGCTGTCGAAGAACTTAGCGATGTCCATGTCCACCACCCAGTTCATCCGCCAGCAGCGTTCCTTGGTCCGCTCGACTGCTTGCAGCGCCGACCTGCCAGGACGATAGCCGTAGGAGTCGCGGTGGAAGATCTGCTCCATCCGCGCTTCCAGCCTCGCCGCGACCACGGTCTGCGCTACCCGGTCCCCCACCGACGGCACCCCCAACGTCCTGGTGCCCCCGGCCTTGGGGATCTCCACCGCTTTGACCGGCGGGGGAAAGTAGCTCCCCGACGACATCCGATTCCAGATCTTGTACAGGTTGTTCTGCACATCCTGCTCAAAATCGGCGATCGACTGTCCGTCGATCCCAGCGGCACCCTTGTTGTCCCTGACCTTCTCCCACGCCCACCAGACCTCCATCTTGGAGATCTCGAACGGCTTGCCTGGTGACTGCTGCTCGGCCACCCGACTCCTCCCCGACCCGAACCGGGCCCGGTTGATCGAATCTCCGAACCACGAATGACCTGGCCCTTCGCTCCACCCCCACCGCGTCAAGCAGGAGCTTCACCACTACTACGGGCCAGTCCGCCAGCGTCGCCGCATCGGTACTCAGCCCCTCCCGGAGCTACCGGTCGGAACGCTCCCTCTCGCCGCCCGATCACCCGGACAGCCGTATCGGCTCCGCCTTCCCACGTTCCACGTGAAAGCCGCAGATCGAGCTCGCGCCGCCTATATGCCGGACACCACCTGGCCAGTAAGTGGGTAGCCGCCAGACTCATCCCAGAGCAGATCAGATGCCCCGGTTTCGATGTCGACCATTCTCCCTTTCGACACTTCACAGGCTGTGACACAACGCCTTCTCGATCCCCACCTGACACTTGAACAGCGCCTTTTCCACCTCGCTCACCACGACGGTCTTCAGCCAACGCAGCAGGTGGCGGTTTGAAGTTGTAGCCACCGACCTTGGCGTGACCGAACCCGATGCCCTGCTTACGCTTGCCGTAGACCCGCCGCAGCATCGAACCGATGTCCACAAAGGTCAGCACATCGGCGCCGGCCAGCAACGGCACCCGGGCGGCCAGGCCGATCAACGTCTGCCGGGCCGCGGCCTGCAACTGCCGCACATGCCCATGGGTGAACGTGCGCAGGAACGAACCCAACGTCGAGGGCGCGTACACGCTGGTGAACAGTGACCGCATGCCACCATGCCGAGCCACGTCGAGGTCGTCGATGCTGTCCGCGCCGGCGCACATCCCGGCCACGATCGTGGCGACCTTACCGGCCGGGTTCGCGCCCCTGTCCGTCGGCACCCTCACCCGAGCGGCGACCGCATCGTGCAGACCGGCCTGCTCGGCAAGCCGCATCACCGGCACCAGCCCGGCACACGACACCAGATTCGGATCATCGAACGTCGCGGCCGTCACCGGCGCGTCATAGCGTAATCTCACCTGCGAGGTGCCCTCTCGAACCGGACGGTAGAAGCTTCGCAACTCCTATCCTTCCAGCTCAGAGGGCACCTAAGAGCGTGTCCCAGGTGGTGGTCGGCTGATCTTCGTGGTAGATCGTTTCTACTGTGGACGAGCGGTTGATCCAGCAGTGGGTGCCTGAGGAGTTGTGGAACCTGGCCGGCCCGTTGATCCCGCCGCCGCCTCGGCGTCGGCAGGGCGGAGGGACACCGCCGATCGATGCGCGCGCGGTGTTCGCGGCGATCGTGTACGTGCTGACCACCGGCTGCGCCTGGCGGCATCTGCCGCCCGGGTTCGGGTGTCCAGGGCCACGGCGCATCGCCGGTTCCAGGCGTGGACGGCCGCTGGACTGTGGCGCCGGTTGCACGTCGCCGCGTTGGACCAGCCCGGCGCGCAGGGGCTGATCGAGTGGTCCCGGGCCACCGCCGACGCCGACTACGTGCGGGCGAAAAGGGGGGCGCTCTGACCGGTCCGAGTCCGGTCGACCGAGGCAAGCCCGGCAGCAAGATCCACGCCTTGTCCGAGCGCGGCGGGCTGCCGCTGTCGGTGGGCGTGTCGGCGGCGAACACCCACGACAGCCGCTGCCTGGAATCGCTCGTCCAGGCCATCCCCGCCGTCCGCTACCGCCGTGGTCCCCGGCGCCGACGCCCGGACAAGTTGCACGCCGACAAGGGCTACGACTACCCCATCTGCGCCGCATGCTCCGCCAGCGCGGCATCCGCCCCCGCATCGCTCGACGCGGCGTCGAATCGGCCAACCGGCTCGGCCGGCACCGGTGGGTCATCGAGCGGACATTCGCCTGGTTCACGGGCTACCGCCGGCTGACCATCCGCTACGAACGCGACCCCAGCCTGTACTGCGCATTCGTCACCCTCGCCGCCGCCCTGACCTGCCACAAGCGCTACCTCAAACTCACCACCTGAGAGGGCGGTCCGCAGTAACTTGATCTGATCTATGCGTTGGGTCCGGTTGGTGGCCTTCCGGCAGGTTCATCACGGATAGCGGCCGGTCGATGGGTTGAATGTGAGTTCTGGTCGTGACCGCCCGGGCGGATGAGGCGTTAGCCCGGTCATGGGTGATCGAAAGCGGTATCCCAGTGATGTCACCGACGAGCAGTGGGAGCTGATCGGACCGTTTCTGCAGGCATGGAAGGCCAAGCGGGTCGCGGTGTCGGTGTCGGGCCGGCCAGGCGACTACGACCTGCGGGAGATCGTGAACGCGATCTTCTACCAGAACCGGACGGGCTGCCAGTGGGCGTACCTGCCGCACGACCTGCCGCCGAAGTCGGCCACCTACTACTACTTCGCGTTGTGGCGTGACGACGGCACTGACCAGGTGATCCACGATCTGCTGCGCTGCCAGGCAAGGGAGAAGGTCGGCCGTGCCGAGGATCCGAGCGCGGTGGTGTTGGACACCCAGTCGATCCGGGCGGCGAACCACGTCCCGGCCGCCACGACCGGCAAGGACGCGGCCAAAAAGGTGTCGGGGCGCAAGCGGGGCCTGGCCGTGGACGCGTTGGGACTGGTCATCGCGGTCGTGATCACCGCGGCGTCGGTCACCGACAACACCATCGGCATCCGGCTGCTCGACAAGGTCGTCGAACACACCCCGACGGTGAGCCGTGCCTGGGTCGACGCCGGGTTCAAGCAGGACCTCGCCCTGCACGGCGCCGTGCTGGGCATCGACGTCGAGGTCGTCAAACGATCCGACACCAAACCCGGGTTCGTACCGATCCGCAAGCGGTGGATCGTCGAGCAGGTCAACGGCACCCTGATGCTGCACCGCCGCCTCGTGCGCGAGTACGAGAGCCGACCAGAATCCTCGGTGTCCCGAACGCTGTGGGCATCGACGGCGAACATCGTGCGGCGGCTGACCGGAACCAGCACACCCTCCTGGCGGCACCGGTGAACCTCCCCACCGTCCTCGACCTGATCACCGACCGGGAGACCACCACACGCCAGCACGCCGACCGGCTCCGCGAGCAGATCACCGCCCTGACCAGCGAACTCGCCCGCCTCGACGGTGAACTGGCCGACCTGGCGACGACCCGCACCACTCTGCGCACCCTCGCCGCCGCCGAGTTCACCGCCGACGACCCCACCATCGCCAGCGGCCCCTACCAGCAGATCCTGCATGTCCTCGGCACCGCGCCCGCCGGCATGCGCGCCAAAGGCATCTGCCTCGCACTCGGCGTCGAGCCCTCACCCAAGAACGTCGAAGGCACCCGCGCGAAGCCGAAACGCATGGTCAACCGCCACGTCCTCACCGAAGACGAACCCGGAGTATTCACCCTCAACCAGAAACGGACCTAACACTCCGAACCGCCCTCTCATGACCCACGGAAAAGTCGACGCGTGGGAGACTGGCACGGTGGTGAGCGTCCTGGAGCGTGAGGTCTTCTCGGAGGCGGAGGCTGCCCGGCTTCTGCGGGTGGCGCAGTCGACGCTGCACTACTGGCTGGAGGGCGACGAGCGTAAGGGGCGCCGACACAAGCCGGTGCTACGCACGGAACCGCGCGGCGGCCGTTCGGTCACGTGGGCCGAGTTCGTCGAGGCCGGGCTGTTGCGGGAATACCGACGCACCCACCGGGTGCCGATGGTCGAGTTGCGGGCATTTATCGGCCTGCTCCGCGAGCAATTCGGGGTGCCCTACCCACTCGCCGACCGCCGGCCCTACGTCGCCGGCAAAAAACTAGTGCTGGAAGCCCAGGCCGAGGCCGGCCTCGACCCGGAATACTGCCTCGTGGCCGCGGTCGGGAACCAGTTGCTGCTCACTCCTCCGTCGGCGGCGTTCGTCGAGCGGGTCACCTGGGACGGCGACGTCGCCGCCGGCTGGCGACCGGACCCCAACCCCCAGTCACCGGTGCGGATCCTCCCGGATGTCCGGTTCGGTCGGCCGTCGATCAAGGGGATCAGCACCGAGGTGCTCTGGGAGCAGGACGAGGCAGGGCTGGACGTCGAGGAAATCGCCGAGACATACCAGCTCGACGTGCCCGACGTGCGGTGGGCGCTGGCCTACGAGAACTCCCAACGCGCGGCGTGAGCAGGATCAAGCCTGCCGAGGTCCGGTTCTACATCGATGCCGACCTCCTCGGCCTCGCGCGCGTCCTCGCCGGCCTCCGTTCCGACGTCACCTATCCCGGCGACCCCGGCACGGTCATCCACAAACGCCAACGCCCCCCGTGCCCCATCGCCTCGCCCGCAGTGAAGGACTCGGAGTGGATCCCTGAGGTCGCGGGTCGCGGCTGGCTGATCATCACCCGGGACCGCCACATCCAGGAACACCGCCTGGAGATCGCCGCCGTGCGAGAGCACCAGGCCAAGATGGTCGCCCTGACAGCCGCCGACGCGGGCAGCGTCTTCGGCCAGTTGGAGGTCGTGATGAGCCGCTGGCGCGATATCGAGCGCTGCCTCGCCGAGCCGCCACCCTTCATCTACGCGGCCACCCGAACCATAATGCGGCAGATCCCGCTGACCTGACATGGTCGTGAACACCGACCTGAGGCGCCGGTCCGATGACGAGCCTGCCCATGCATGTCCCACGCGAGCGGGCTTCGTTCGTGGAGCCAGTCATGTTGACGAGATGACCACGAGTGCGAGGCGGCGTGTCGATCTTCCTGAAGAACCTCCCCCGGCCGATCGGGACCAAGACCTCCGGGTCTTCATGCAGTTCGAAGCGATCGCGAACCTGCGGTGGCCCGACGACGTGGTGCGGCAGTGGCTCTACGACCACGGCGGACACCTTGAGTTCCTCAGGGACTACGAAGACCTCGACCTCGAACGGATCCGCTGGAGCCTCGAGGACGTTCCCGTCGCAGAACTCGAATCGATTCCCACCGGCGCCAGTGACCAGGGATTCCTCGAGGAGGTCGCGGCGAACCACGAGTACTGGCTGAGCAAGCGCCCGCAACGAATTCAGGACGCATGGAAGATCCAGGGAACGTGGCTCATACCGCCGATCATGATCTCCCGCAACCTTCTTCATCCATCGAACCGCGGGCTGCAGGTCATCGAAGGGCGGATGCGCACCATCTTGCAGGGGCGACGCTCCGGTGGCCTGCATGTCGCCGACAAGCATTCGGCATGGGTTGGAAGACCAGGCTGATCCGCCCCGTACAAGACCACGCCGGAGAGGTGGCGGCCATCGAGCACGGGACCGGTCGTTGGGATCGCATTGTGTTCCTAACACCCCACCCCAGCAGCCCTCGCCCCACGCCCTCACCAGCACCACCGGCGGCGGAACGACCACCAGCTGCACCTACGACAACGGCGGCTACCCCAAAACCCGCACCAGCGGTTGCGCGGGCGTCGCTCCCTGGCTGCTCGGTGGCTGCTCGAACGTCGGCGAACTGGCACGGACTCATCGGGACTGAGCCGGATTTCACCCTTGCAGAAACGGCGTCAACAAGTCCACCGGCCGATATGCGGTCGGACCTTCGGGGATGTCGCCAGATTGGCTTCGGACGCGACCGGACGTCGTCGCACTCTCGCCACTCCCTGCAAGATCATCTGACTACGGATCAGATGCTCAGAGGCGCTCGACCGCTAGCCATTACTGATGCGGCGTAGCAACTTCGATAAGCCCCAGCAAGGACACACCAGACCGAACGCAGCGCGGCCTGAGCAGGACTTACGTCCGCCCTGATGGTCTTACACAAGCGCAGTCTCTACGCGAGTTCGCACAGCGCCACCTCTGCCGATCTTGGCTGTTTGGGCTGGTAAGGGGTCTTGTCGCGGATGCAGACCCAGAGGACGTTGAGGCGTTGTCTGGAAAGGGCGGCGGTGGCTTGGCGGTGGGTTTTTCCTTCGGCTCTCTTCTTGTCGTAGTAGGCGCGTGATCGTGGGCAGTGGGTCAGGGCGGTGAAGCTGGGCATGCTGAACACCCGGCGTAGACCACGGTGGTAGCGGTACGGCCGGATCTGGTGACCTTGGCGGCGTCCGGAGTCGCGGGAGATCGGCGCGAGCCCGGCGTGGGCGGCGAGTGCGGCGGCGCTTGGGTAGGTGGTGGGGGTGCCGGCGTGGGCGAGGAACTCGGCGGCGAGGGTGGTGCCGATGCCGGGCAGGCTGATGACGATCTCTCCCAGCTCGTGCTCGGCGACCATCGCGGCGAAGGTCTCCTACACAGATGACCTTGACCCGCTAGCCGACATGCCCGGCAACCCATACGATCCACCGCCATCGGCGGCCGTGCCCGCATCGAGACAGCAGCACGCCGAGAGGATGCCTTTACGCCGCCGCCCCGCCAGCCGTGGCATCCGAACCGCCGCTGGTACCACGGCTAGTAACAGTGCCCGGCCGGCAGGTACGGCCGCAGGTCGTCCCGCTCGGATTTCGGCGCCGTCGGCATGCCCTCCCGGCTGAGCCGGGGATCCACGCGGTCGGCGTGATGCAGGATCCACGTCGACCAGGCCCGCACCTCCTGCGCACGGTAGGGCTCCAAGTCGTCAGCGACCGCCGATAGCGCTGGGCCTGATGGGCGAGCTGGTCGGCTTCACGCTGAAGGAGCCGGCACACCAACCTCTCCGGCCCGGGCAGGTGGCCGACGCGACGCGCCGGATGGTGGACCAGTCCGGGCCGCCGGACCTCTCGTGTCCTGCGCCGCGAGGCGCTTCGCCGGGCTCCTTCCCCCGGAAGCGTGCAAACGCACGGCGGCACCGACGCGTAGGCTCTAACCGCGGGGCGGAAAGCGGGTCGGTGACAGCGAGGAGCCCTTTGATGCACCGGATCGGAATCATCGGGACGGGCGACATCGCTCGTAAGGTCTACCTGCCGCTGTTGACCGGGAATCCGGATGTCGAGATCGTCGCTCTCACCAGCCGGACTCGCGAGAAGGCCGTCGCGCTCGCACGCCGACATCGCCTCGACGTGGTGGTCGACGACGTCGGAGAGGTGTTGCAGCTCAAGCCGGACATCGTCTTTATCCACGCGTCGACCAGCGCGCACGCCGAGCTCGTTCGAACCTGTCTGGACGCCGGGTCCCACGTCTATGTGGACAAGCCGCTGTCCGAGAGCCTCGACGAAACCCATCGCCTGGAGCAGCAGGCGACAGCCCAGGGGCTGCTCTTGGCCGTGGGGTTCAACCGGCGATTCGCGCCGATGGTCCGCGCGGCGGTGGAGGCCGTACCGAATCCAACCATGATCATTTCCGAAAAGCATCGACGGTCGATCCGACCAGACCGGCCTTTCGGTACGGTCTACAACGATTTGATTCACGCGATAGACCTGGCCTGCTGGGCCGGCGCGATTCCGGTCGATGCGGTGGTTCAAGGGGCCGGAATCGTCGACGGCGACCACCTGCGTGCCGCGACAGCCGTGCTGTTGGCGTCACGATGTCACGCGCACGTGGCCATGAACCGCGACGCCGGCGACGACGCGGAACGGCTCTTCATCGCCGGTGACGCCGTGTCGGCAACTGTCGTCAACCTCGACATGGTGATGGTCCAGGAGAGCGGCACCACCACGACACGGACGTTCGGCAGTTGGGACGGCATCCTGCTGCGTCGCGGATTCGTCGGACTCGTCGACCACGTGCTGAACTCACTGGGCGCCCCGGAGCAATGTCTGGTGTCGGCGACGGCGGTTCTTCGAACTCACCGCGTGGCGGACCAGATCGCCCGTAGCCTCACCGGGTGTTAGACGGCGCTCATGGCGAGTCGAATCGGATGAAGGGCTTCAGCAGTTCGCCGCGATAGAACCGGGCGAACACCTCGGGCAGCTCGTCGAGAGTCGCTCGACTACTGAGAACCGACACGAGTCCGGGGCCAACCCGCGCGAGCGCGGCCCAGTTCGCCTCGACCTCGGAGAGCGGAAAGTAGAACGTGCGAAGGTTGAACAGGTTGGTCCGTCTCGTGCGGGGGTTCGCCGGTATGACGAAGGGCTCGTCGGACTCACCGAGTGCGAGCAGCACCGCGCCTGGCCGTACGAGCCGTTGTGCCACCTCGCGTCCCGTGCGGGAACCGCTCGCTTCGACGACCAGGTCGTACTGATTCTCGGCGTCCAGGTCACGGAGCCTCCGCGCACCCATGCCAACGGCTGCTGCGAGCCGACCGGGGACGGGGTCAAACACCTCCGGCACGGGGAGCCCCATCTCCAGGGACATGACCGCGACGCCGAGCCCGAGCGGGCCACAACCGATGACGGCGACGCGCTCGACAGCCCTCACCTGCGTCCGAATCGCCCACCGCAGTCCGTGGGCCGCGGTCCCCACGGTGTCCAGGCCCAGCACCGCGACGTCGAGCGACATCGCATCGGGTACGCGAATGAAGCACTGGGCCGGCACGTCCACGTGCGTCGCATAGCCGCCATCCCGTTGCCAACCGACCAGCTCCGCCAGCTTGAGGCAGCCGTTAGTGAAACCGACCCCGCAAGACGCGCACGCCCCACAGAAGACAGGCGCGTAAACGACCCCGCGTTCCCCGACCCGATGCGTGGGAACACCGCCCCCGACTGCCACGATGCGCCCCGCGATCTCGTGACCAGGGACGACAGCGCTACCCTCGCGGTACGGCCGCTTGTCCGAGCCGCACAGAGCCGAGACTTCCACCGCCACCCTGACGTCACCGGCAGCGATGTCCGGCAGCATCTCCTGCGCCAACTCGACGACGCCGTCACCGAGAAATCGAGCCCGCCTAGCTTTAGTCACCGTCGTGGCTCCTTCCCGGTCCGGAGATACCGTCATCGATGATCGGTTGCAACCACTCGCCGAACCGCTCCTGGCGCTGGAGGTCAGCCGGCCAGAACTCCTCCGGTAGTGGCTTCGTCCGGCCGGCCACGCCCGCTAGGGGGACCGGGTCCACGGCGAGGGCGAGCGGAGCGCTCTTGAGTCGCCGGGTTCCGGCCATCACACCACGGCGCCCTTCCAGCACGTACCGCCCGGCCCACTCGCCCGTCAGGCGGGCACACTCCAGGTCGGCCGCGCTGGCGAATGAGTAAGCGCTGCGTTGCTGGGTGCCGAGAACCTCTCCCCGGGCAGGACGACCCAACTGCGCCTCGAGCATCCGCGCCAGGCGCCGGGAAACCCCACCGAGCAGGAGCGTGCTGTGGTTGCCGGCGCGGTAGTCGTCACGCGAGCCCGAGAATGGAAACCCTTCACTGCAGACGAGGAAGGCCCTCGACTGCGCCGCCAACGCGTTTTCCACGGCATCGAGGATCTGCGGGATGGTGGTGTCGGAACGCTCGGGTATCAGGCACAGATCAGCGGCCAGGTTCGCATTCTCCAGAACGAGCGCGGCCGCGGCGGCGGCCGCCAACCAGCCGGTCCCGCGCCCCATGGTCTCGACGACGCGGATCGGCTCTATCGACGACATGGTGGAGTGATCGCGAGCGATGCCGGGTACCGTCAGGCGGAGGTAGCGCGAGGCGGACCCGAACCCCGGGCTGAAGTCGACGCCGAGCAGGTCGTTGTCGATGGTCTTGGGAATCCCGACGGTCTGAAGCGAGAGATCGCGGCTGCGCGACTCCGCATCTACGGCATCCAGCAGAGCCATGGTCCCGTTTCCCCCGGCGAGCACCAGCGCATCGATACGGGCAGCCTCCAACCGGTCGACTATCGCCGCGATGCCCTGGGAAGTCAGCGCACGGCGGCCGCTTCCCAGCACACAGCCGGCGACGGGAGCCGAGGAGAGCCGGGCGGCGTCCAAAGAAGCGAATGCTCCCTCCACTAGGCCGTTCGGTCCGCCCGTGATCCCCCGGACATCGCAGACCCGTGCCAGCACGTCACGGCAGGCCCGCAGGCTGGCCTCGACGACGACCGTCGGAGCACCGGCCAGGCCGAGGGCGACGCTACGCGGCATGGCGTGGGCACGGCATCGCGACAACGGGACCGGTCATCACGGGACCTCCCCCTTGCCAACGTGCACCGCTCATGACTCGTTCCGTGGTCCATCCCGAACTCGGCACCGGTCACCGCCCCATCCGGAGCGGCACGACGGGCGGCGGGACCGCCTGCGCGCCGGCTCCTCGGGAGTGGCCGCCGCTCTCGAAACCGGGCGACTCAGCCTAGCAAGTCGCTGGAAGTCGATCGAGTGCTGCCGATCGGTGGTGCGCGAATCGCGTTGGTAGATCAAGCCCGGCCGGTAGCCGCCCCGGGGCCGGCCACACCCCGCCGCCTGCCGCTTCGACGCCCATCACCGCTTCCGCCCGGGCCGGCCGGACCACGGCTTCGACGATTGGTCGGACGCGGGGATTGCCCCGGCCAAGTACGCTCGGCGTAGCCGGCAAGGTCGACTTCGGTACGGCGGGTCGGAGGGTCCCCGGTGGGTGACCCTTCCCACTCAGCAACACTGCAATCTCGGGTGATCTCGTATGACTCAGAGAGGGCCGGGCAACTGAGCACACTCGCGTGGGAATCAGGTGATGGCCGGACCATGGAGCACTCCTGGCTGCGCTTGGCCGTCAGTCATCCGATGTGGTCCCTGACATTTGGCGAGGCAGACGGCCAGGACTTCCTCGCCGGTGGTTGCGCGGACAGCACTATCCGACTGTGGAAGGCGAGCACCGGGGCTCCGGTCCGCCGACTGCGCGGCCACACCGGCGCCGTCCTGTCGGTGGCGGTCGGCGTCGTCAGCCGCCGCCCGGTGTTGGCGTCCGCCGGCATCGACGGCACGGTTCGGCTCTGGGATCCGAGCGAGGACGACGCTGGCCACCGGACCCTTCAGGGTCATGTCGGGGGAGTCCGGGCCGTGGCATTCGGCCAGACCGATGGCCGCACGTTCCTCGCGTCCGCAGGCGCGGACGGCACCGTCCGGCTCTGGGACGCCGAGGCCGGTGTTCCTGCCGCCGAACCGTTGACCGGCCACTCCGGCACCGCCCTGTCCGTTGCCTTCGGGCTTGTCGGAGACCGGTACGTGCTCGCGTCTGCAGGCGACGACGCAACGGTGCGGTTGTGGGACGCCGAGACGGGCGCGTCTCTGATGGATCCCCTTCGACGGCACAGGGGCGGCGTGCGATCGGTGGCCTTCGGTCAGGTCGACGGGGTTCCATTCCTCGCGTCGGCCAGTGACGACGGCACCGTGCAGCTGTGGGATCCGCAGGCCGGTGTTCCCCTCTTCGGGCGTCTCACTGGTCACTCCGGCATCGTGCGAGCTGTCGGCTTCACCCAGGTCGCCGACGTTGGTCTCGTCATGTCGGCAGGCATCGACGGCACGATCCGGATGTGGAACCCGAACACCGGCGTCGGGTACCCCGATCACATCACCGCCCCCGCCGACGACCTACGGGCCATCGCGTTCGGAAAAGTCCGAGGAGAGGACGTCCTCGCCATCGGCTCCGGCCAGGGCGTCTCGATGTCCCTCCTTGCAGATCAGATAGACACCACCAAGCTGCTTGCGCCCGACATCGTCCGTTCAGCGATCGTCACCGCGGACGCGATCGACGCCGCGGACTACTTCGGCCGGGTGATCCTGGCTCGTCATCTCCATGGTGTGATCGGCCAGTTGATCGCCCCGGGCGGCGCGAATTCGCATCGCAGCGTCGTCGTCAGCATCGACGGACGGTGGGGAGCCGGAAAGACCACGCTCGCTCGCCTCCTGGTCGAGGAAATGCGGAACCACACACCGAGCGCGACACCTTCCCCCAGCCCGACTGAGACCCCGGGGAGAAACGGCCGAGGCATCGCCGCGCTGCCACGCGACCCGGTCGTGGTCAACTTCGACGCCTGGCGCGAATCCGAGATCGCTCCGCACTGGTGGGCCGTGGCCGCAGCGATCAACCGGGGCATCCGGAGTGAACGCAGTCTCGTTGCTCGGATCGGAATGACCGTGACCGGGGTCGGACGCCGGATCGCGCGGTCACCGGCATCCCTTGCGGCAATGCTCATCGTCTCGGTGGTGGTCTTCGGATCCATGGCCATCAGAAGCGCGGCGCCTGCCCAGCTCAACCAGACGCTGACCATTCTGCAGACGTTCCTGACGGCAGCCACCGCCCTCTTCGCGGTCGCCGCCGTCATCACCCGTTCGCTGTTCTGGGCCTCTCCCGCCCTCGGCCGACTTCATCTGCGGGCCGATGACAACCCGCTCGGCGAGGTCGCCGACATGGTTACCAACCTTCGCCGCTGGAGTCCACGCACCGGCAGCAGCCCGCTCGTGGAAACCGCCGCCGTCGTAATGTGGATCATTATCGGTACCGTCGCTGGACGCCTGATCTACTCTCGCCCCGAGACGGTTCTCTCGAACGCGGACTGGTCGGCCTGGGTGCAGCGCCATCTGATCGCCATTTCGGTCGCCCTCGCGACCGCGCTCGTGGTCGGACTGGCCACCCCCGTGACGGTCCGATCGGCCTCACGGTCGATCTGGCAGGGCTCCCCTAGCAGTGTCGACTGGTCCGCGGACCCTCCTCGTTCCCGCTGGTACACACGGCCGAACTGGCGAGCCCGAGCCGTCTGGGCGGTCATCGCCGGCTCGATCGTCGGCGTCGCGGGGTCGGTGGCACTACCCGAGATGGCCGGTCCGGCATGGCTGCCGCTCATCGTGCTGGGTGGGCTGGGCATCGCCGGTCTCGTCGCTCAGCTCGTGTACGTCCGATCACCGCGCCGCCGAAACCGACGTCCGATCGTCCTGGTCATGGACGAACTAGACCGTTGTTCGGTGCCGACGGTGGTTGCCTACCTCGAGACGGTTCACACTCTCCTGAAGGAACGCTCGCCAGGCGCACCACCCTCGCTGCGGAACGGGTGGCGGGATCCGGCCCCGCTGGTCGTGCTGGTGCTTGCCGACGGGCGTTGGGTACGAACGGCGTTCACCACAGAGTACGACGCGTTCAAGGATCTGGGGTCACCCGTACGCACGTTGGGTGGAGACTTCCTGCAGAAGCTCTTCGACCACACAGTCCTGGTGCCCGACCTCACGGCAGACCACGTCGGGCATCTCCTCGAACGCATCACGATGCCTGCCGTGTCGGCCGAGACCCGCACCGGCAGGTGGCCGCCAGCCGAATCGCGTCCCGCCGCCGACGCGCAGTCGACGGGTGGGCCGCCACCCGACACCGACGCGCGGCCGGCCCAGGACGACCCCACGGCGCTGGCCGCCGAGCGGGAGCGCGTCGCCGATGACGCGCGGGCAGCCGCCACCCCGAAAGCCATCGAACGTCGAGAAGCTCATCTGCTCGCGTCGTACACCATGCTGCTGCCCTCCAATCCGCGGCTCATCCGTCGGGTGGCCAACACGTGGGCGATGCTGGAAGCGCTGAAGCATCACGTTGGACATGACGAACTGGACGACGTCGTTGTTCGCGCTGCGGTGATGTACGTCACTTTTCCGTCACTCGTTGACACTCTCTTGGACGACGTACGCGCGCCCGCCCTGCCCGACCGGCTCGACGATTCCGCAACCGAAACCGACCGTGAGAGCCTGTGGCTCCGCCCCGATGTGCTGGCCATCATCACGCGCGAGGACGGATCAATTGTGTCACCGGCATCGATCGCTCGCTGTTACGGAAAGGCCTATGCGCCGAGGCGCTCGGAGACGTCGGGCATTCCGGAGCAGCGTAACGCCGCGAAAGGAAGCTAAGTGATTGGTTACGCCATCTGCAGCGTCGAACGGACAGGCAGTACGCTCTACTCCGCGCTTCTCGAACAGACCGGCATAGCGGGCAGGCCTGTCGTGGAGCCGTTCAATGCGAAGATCCAGTCCACCGCCTTCCGCCACCACCGCTTCAGCACCTACCACGAATACCTTAAATTTGCGCGTCGACAGGCCCGCACGCCGAACGGGATATTCGGCATCAACATCATGTGGCGTCACCTCGCCCGTGTCGTCGGAGAGTTGGAACGGGCGCGATCTTGGAATGGGGAGACGTCGGTTCAGATGCTCCAGCACTACCTGCCGGAGCTGACACACTTCGTATTCACCCGGCGTCGCGACACGCTTGCGCAAGCTGTATCCTGGGCCATCGCATACCAGACCGACCGCTGGAAGAGCACTGATCCCGACCTCGGCCGCACCCCTATGTACGACTTCCCACTCGTTGACACGCTGCATCAGAACGTCGTCGCCGACAACTTCGGCTGGGAAAGCTGGTTCAAGCTGAACGGCATCGAACCACTCAGGTTGACCTACGAAGATCTCGTTGATGATCCACGACGGGAGATATTCCGGACGCTGGAATTCCTCGGGCTGGACACTCCTGCGGAACTGGCGCTCGCCACCCACATCGAGAAGCAGGCAACCGACCTGAACCATACTTGGCGCGACCGCTACCTTGAGGACAAGGCACGCAACAACGTCATTCAGCTGCCGACACCGTGGTTATCCGACGGCGGAGCTTAAGAGCGGCCGTCGGAGCACCGCGCGCGACATGTCGACGACCGGGTTGGGAGTGTGTCGATTTCTACGCAGTCCCTATTCGGGTGGGTCATCACCACCCGGTGGGTCATCACCACCCGGCACGCGCAGCCAAGCGCGCCACGCTGCTGGCCCAAGCTCTTGCGGCACCGTAGACTAAAGCGAAGCGGCAACTTCGCCGAATCTCGGCAAGGGCGCGTCGAACTGACCGAAGCAAGTCCTGAGCAGGGATTACGCCTATTCTGTTGATCTTCAACAAGCGATCACAGCAACGCGCTTGTGCGACCCACTAACGTCGAAACACAATAGGAGTCTCCATGTGACTCCGGATGATCTTGGCGGGCAGGGTGGATCGGCCGGCCGGACCTGGTCGAGTCGGCGGAGAGCGGTCTGGTTCAGGCTGCGGCGCGGATGGTTGATGCCGGTCGGGTGAAGGTCTTGCGGTCGCGGATGAGTGCCCACAGGACGTCGACGCGTCGTCGGGCGAGGGCGAGTATGGCCTGGCGGTGGTTCTTTCCTTCGGCGCGTTTCCTCTCGTAGTAGGCACGCGAGGTGGGGCATTCCCTGGCGGCGGTGAAAGCGGCCATCCACAGAATGTGCCGCAGCCTGCGGTGGTAGCGGCGGGGCGGCCGATGGTTGCCGGCAACCGTTCCGGAGTCGCGGGAAACGGGTGCCAGGCCGGCGTGGGCGGCGAGTTTGGTGGGGCTGTCGTACTCGGTCATGCCGGCGGTGTGCACGAGCAGTTCGGCGGTGAGTAGGGGTCCCATGCCGGGCATGCTCTCGATGATCGGCGCCAGCGGGTGCTGGTCGAGCTGGTCGGCGATGAGGTCGTCGACGGCGGCGATGCGCTGCTCCAAGGCGAGGATCTCGGTGGCCATCTGCCCGACGACCACCGCGGCGGCCCGTTGGCCGGGCAGGTTCACGGTCTGCTGCCGGGCGGCGGCGACCATCGCCTCGGCGACCTGGACGGCGTTCTTGACGTGGCCGCGGCGCAGCAGGGCGGTGATCCGGTCGACGCCGGCGTGCCGGATCGCGGCCGGAGTCTGCCAACAGGCGAGGACCATCATCGGGGCCTTCCGGTTCAGGTCCACGGCCCGTTCGAGGGCGGGGCTGATCCCGGTGAGGAGTTCCTGCAACCGGAACAGGGTGGCGACGCGCTGCCCGACGAGGTCGGCGCGGTAGCCGGTGAGCACGGTGAGTTCGGCGAGGAGCCGGTCAGACGGTTCCAGGATCGGGATGTCGGGGCGCATGCGGATGGTCTGGGCGATGACCACGGCGTCGCGGGCGTCGGTCTTGTTCTCCCCGGCGAACGCGGCGGCCATGTGAAAGGCGACGGGCCCGGAGACGTAGCGGACCTGGACCTGACGCCGCCACAGCAGGGTCAGCAGCAGCGCGGACAGGCCGGTGGTGACGTCGACCGCCCAGCACACCGGCCGGCCGTGCGTCGACACCTCGGCCATGACCGTGAGCAGGGCGGTCTCGTCGTTGGCGACCCGACGGGAGTAGACCAACCGGCCGTCGCCGTCAACGGCGGCTACGTGGTGGTGGGTCTTGCCGATGTCCACGCCGATCCACAGCTTCGCCACCCTCGTGCTCCCCTTCATCGGTCAGTCTTGGCGAATGGCCCTGGTCTGCGGGTTCGGACTTGCCGGCACCTTCTCACGATGCGAACGCAGGTCGCGGATCTCCATCAGCGGTCTACCGAATCTCACAGACGACGAAGCGGCGGGTGGCATCTCCTACCGTGAGCCAAGCGATCTCGACGAAACACACGCAGCCATACCCACCGCTCCCGGGCATCAGGGTCTACGGCTGTCGGTGCCGCGCCCGTTCCACCCGGCCCGCCCGCGAGCCGGGAAAGTGGGTGGCACCTCGAGGCTCAGCCACGATCACGGCGGAACACACACAGCCATCCCCACTCCCGGCTCTGCGGGCGCGGCAACCCTGAGCCTGCCGCCGCTGCCGGCCGGCACCCCGGACACGATGTGCGGGACCTTCGCAGCATCAGGGCATCACCGAGCGTAGGGCGGGCGTACGGCATGGTGCCCAGGCCGGCTGGTCGCCGGCCGCCGTTTCGCGACCGGGCCTGATTTCCACGCGTACCGGGCTCGCGGCGACCGATCAGTACGGCTTCGCGTGGCATCACCGGGGCCGGCAAGGCGACCACGATATGGGGCCCTGGTCTGGGGCTGTGGCCGCGCGTGTCAGGTGCACCGTCCTTCTGTGGCGTGGGGGCCAGGTTGGCCGACCAGCGTTCCTCGACCCGGCCGAGCCGCCAGACCGCGATGGCGACGAGCCAGGCGACGGCGAACAAGCCCGCGATGGGTCAGCCGGTCGGGCGGGGCGCATACATGATGACCGCGACGCCGGCCAGGCAGATCAGCGCACCGATGACGTCCCACCGGTCCGGACGGAACTTGTCCACGACCATGCCCCACGCGAGGGACCCGGCGACGAACACGCCGCCGTAGGCGGCCAGGATGCGCCCGAAGTTCGGGTCGGGCTGGAACGTGGCGACGAACCCGTAGGCGCCGAGCGCGATGACGCCGGCGGCGATCCACCACAGGCCGCGGTGCTCGCGCCAGCCCTGCCAGACCAGCCACGCCCCGCCGATCTCGAACAGCGCGGCGACGACGAACAGCAGTATGGAACGGGCGACGGTCACGTCCGGACCGTACCCGGCGCACCGCCGCCCGCGATCATGCCGGTGACCCGGTGGAGCAGCCGCAGCTCGTCCCACCGGCGCAGCCGCCGCGGTGGCGGCGCCGACTCGCCCACCACCACGCGGCGCCGGCCAGCGCGGCCAGGGCGACGGCGATGCCGGGCATCCACGCCCCCGCGGCGGCCCACCCGGCGCCGGACAGCACCCCGGCGGCCAGCAGCAACGGGAGGGCGCAGCACGCCGCGCAGGCCACACCGGCGAGCCCGGTCAGGCCGGAGGGCAGCACCCGGCGTGCCCGGCCAGCAACCCGATCAACGGTCTTCGGCATCCGAGGCTCCTTCGGCAATGGTGGCGAACGGGATGGGGCAGCACGGCGCTCCGGCGCACGCGACGAGGTCGTCGCAGCCGGCGTCCACGGCGGCGCGCAGCGTGCCCGCGATGACCTGCAGGTCGGCGATCTTCGCCTCCACCTCGGCCAGCTTCGCTCGGGCGCGTGACTGCAGCCCGGCGTCCGGGCGCCGCCCGTGCCGGTGCTGGCCCGCTTCGAGCAGGCCGGCGACTTCGTCGAGGGCGAAACCGAGCCGCTGCGCCGCCTTGATCACCTTCAGGACGGTGACCGCCTGCTCCGGGTACAGGCGGTGCCCGCCCAGGCTGCGCTCCGGCTCAGCGAGCAGGCCGCGGCGCTCGTAGTAGCGCAGCGTCTGCAGGTTCACCCCGGCCGCGGCCGCGATCTGACTGCTGCGCAGCCCGCTCACGCCGCCATCCCGGCAGCCGCCCGAGCGGCGAGCGCGTCCAGGACGTCAACGTGCCCGGCCGGAACCTGCACCTCCAACTCCACGCCGTTGCCGCCAGCGGGGGCCAAGGTGAAGGTGAAGAAGGAGCAGCACACGCTCTCCCGCCCGATCAGGTCCCGTGCGGTGGCCTCGGCTGCCGGGGCGAGCTGCCACCGCAGCCGCGTCGGCGCCGGCCGCTGCTGCCCGACAAGCGCGGTGGCGAACAGGTCATCGAACTCGGCCAGCCGCAGCGGCCGCTGCGCGGTGGGCAGGGTGCATGCCTCGGGCACCCACGACGGACCGGTTACCTCGTCGTTCGTGGTCATGCCACGACGGTAAGCCTGTACCCAGGTACAGGATGCAAGCCCTTCGGGCCGACTTCGACGCCGCGCCTTCCACCGCCGGTGAACCGTGGACCGGGCCACCACACAGCTCGGCCAGGTCCGGCACCCATCCGGGACGAGCCAAGCAGACCACCTCTGGGCCGCCAGCGTTGGTCGTGGCGGCCCCGACGCGGGTCAGGTCCCCGCTGGGCGGGTCGGACAGAGCGCGGCGTCGAGCACCTCGACTGGTACGCCGACCGACGCGCCGGAGGCATGTGGGCGGTGGTCACCCCGGCGGTGGTGCGGATCATCGCGTGCCGGGGGGATCGCCTGCGAGGTGCGCCCGCTCGCGGGCATCACCTGTGGCCATACTGCGGCAATTGCCAACTATTTGCAACAAGGCTGTAGCGGTGGAGCGGGGTTGCGGTCATGGGGTGACCGGGGGACTCCCCGCCGTCGTGGCCACGAGCAGGGACAGCTCGCGGACCAGGTCGTCCATGCTCTGGCCGCTCTGGGCCCGGACCAGGCCCAGCGCGAGGTCGGCGAGCAGGTAGAAGCCGAGGGTGCGGGCCTGCTCGCTGGGGAACGCGGCGAGCAGTTCCTCGGCGCCGGCGGGGTCACCGCGGTGTTTGGCGGCGATGACCCCGGCGGCGCGTTGGAGCAGCTCCGCCGCGGCGGGAGTGGCTGCGCTCACCAGGTCAGATCTTCGGGCTCGTGGCGCGGGCGGCGTCGAAGCGGGCGATCACGTCGGACCAGTTGACGAGGTTCCACAGCCGGTCGACGTAGTCGGGGCGGACGTTCTTGTACTGCAGGTAGTAGGCGTGCTCCCAGGCGTCGAAGACCAGCAGCGGCGTGGAGCCCTGCCCGACGTTGCCGTGGTGGTCGTAGACCTGCTCCACGATCAGCCGCTGCCCGAGCGGCTCCCAGGCCAGGACACCCCAGCCGGAGCCCTGCACGCCCTTCGTGGCCGCCGACAGCTGCCCGGCGAAGGCGTCGAAGGAGCCGAAGTGCTCGTCGATCGCGGCGGCGAGGTCGCCGTCGGGGCGGTCGCCGCCGTCCGGGGACAGGTTGTTCCAGAAGATGGTGTGCAGCACGTGTCCGGAGAGGTTGAACGCGTACGTCTTCTCCAGGCCGACGAGCTTGCTGAAGTCGCCCTTGTCGCGGGCCTCGGCGAGCTGCTCCAGGCCGTCGTTGGCGCCCTTGACGTACGCGGCGTGGTGCTTGTCGTGGTGCAGCTCGAGGATCTGCCCCGACATCGCCGGCTCCAGCGCGCCGTAGTCGTAGGTCAGGTCGGGCAGGGTGTAGACCGCCATCAGGATCCCTCTTTCGGTGATGCTGCCGTAGTTTTGTTGTTGCCAGTATCTTGCAACAAGACGGCGGGTGGTGGGAGGAGCGGGGATTGATCACATCGCGGGCCGATCGGGTGGACGCGGCGCTGGATCGGCTGCGCCGGGCCGGCCTGCGCACGACCCTGGCCCGGCGTGCGGTGCTGGACGCGCTCGGCGACGCCGCGGTCGAGCGGCGACACCTCAACGCCGGCGAGGTGCACCGGCGGCTCACCGGCCGGGGGCTGGCGGTGGAGCTGTCGACGGTGCACCGCGTCCTGGGGCAGCTGGTCGACCTCGGCGTGGCGCATGCCGTGCCGGTGGGCGGGGCGGCCACGTTCGGGTTGGCCGACCACCCGCACCATCACGCGGTGTGCGAGGGCTGCGGCGGCATGCGTCAGCTGCCGGTGCCGGCGGTGGCGGCCAGTGTCGCGGCGGCGCGGGAGGTCGGCGTCGAGATGGACGGCGGCAGCGGCGGGGTCGTCGTGTACGGGCGGTGCCCGGCGTGCCGCGCCACGACCACCTGAGCGCGCCGGCCGCACGTGCCCGACCGGCGGCCGATCCGAACGCTGAGCCGGCGCCGGTCCCGCGTGCGGCGGTCCGGCGCCCGCAGGCCTTCACCGACAGCCGCGAGATGGTGGCGCTGGCGGTGCAGCTGGCCAACGCGCCGCCGGGGAACACCCCCGCGGAGGCAGCTGTCACGGTCGGGTGGCCGGGCCTGCGCGAGGTCGCGACGCCGGCTGATCTGCCGCTGCTGCACCAGGCGGGCCGGCAGCTCCGCGAGGTCTTCGCCCACGCCGGCGCACGCCGTGACCGCGAGGCCGTACACGTGCTCAACCGGCTCCTGGCCCGGCACCGGCTCCGGCCCGCCATCGCCGGCACCGGCCCGGCGGACCGGCACCTACACGTCGCCGCGCCCGGCGCCACACCGGCGGCCGAGCACGTGGCCGCCGCGGTGTGGGCACTCGCGGTGTTCCTGTGCGAGCAGGGCATCGACCGGTTCAAGACCTGCACGGAGCCGGGTTGCGGCATCGTGTTCCTGGACGAGACCACCAACCGCCGCCGCCGGTTCTGCTCCCCGCGCTGCGCCACCCGCGCCCACGTGCGGGCACACCGCAGCCGGCGACGGACGGTCACCCGCTGATCAGCCGGCCCGGATCAGGCCGGCGACGGTGGCCAGCGCGGCATCGGCGGTCAGACCCGGGGCGCCGCCCTGCGCGAGGCGGGCGGTGCCGCCGCCACGTCCGCCGAGCGCGGACCTCACCAGCTGTACGGCGCTGAGCGCGTCGGGCGTCGTCGCGGTGGTGGCGACGACCAGGCGGGTGCCGCGCTCGGCCGGCGCGGCGACGGCGACCACGCCCGGCCGGTCCTGCGCAAGGGCGGCCCGGACCAGTTCGGCGAGCTGCCGAGGGTCCTCGTCGGCGGCGGCGACGACACTGACGACGAGCGTGCCGTCGATCTGCACCGCATCGGCGGCAAGGCGTCGCGCCCGCTGCGCGGTGAGCTCACGGGCGAGCTGGTCGGCGCGGCGCTCGGCGGCCTTGGCGCGGCCGAGCAGCACGGTGATCCGCTCGGGCAGGTCCTCGCGCGGGGCCTGCAGCTGCGCGGCGAGTTGAGTGACGAGGTCACGTTCGCGGGCGAGGTAGCGCAGCCCGTCGAGTCCGACGACGGCCTCGACGCGGCGGTGCCCGGCGCCGACGGACGATTCGCCGGTCAGCGCGAGCAGGCCGATCTGGCTGGAGTGGGCGACGTGGGTGCCGCCGCACAGTTCCCGGGACCACGCGCCGCCGATCTCGACCACCCGGACCTGCTCGTCGTAGGTCTCCCCGAACAGCGCCAGGGCACCCAGTTCCCGGGCCCGGGTCAGCGGCATGACCTGCGCCGTGACCGGCAGGTCGTCACGCAGCGCCTGGTTGGCGACGTCCTCGACCTCGCTGCGGGTGGCCAGGGGGAGGCCGCCGGGCCAGGCGAAGTCCAGCCGCAGGTAGCCGGGCCGGTTGTAGGAGCCGGACTGCAACGCGGTCGGGCCGAGGACCTGCCGCAGCGCGGCGTGCAGCACGTGGGTGCCGGAGTGCGCCTGCCGGGCGCCGCGCCGCCAGGTCGCGTCGACGTTCGCGGTGAGGCGGGCGCCGACCGTCAGGTGCCCGGCGGTGACGCGGACCTGGTGGGCGACGAGGCCCTTGACCGGCCGTTGCACGTCGATCACCTCGCCCGCGCCGTCGGTGCCGGTGAGGTGTCCGGCGTCGGCGGCCTGCCCGCCGGACTCGGCGTAGAACGGGGTGACGTCGAGCACCACGGTGACGATCTGCCCCTCGGTCGCCGCGGGCACCGGTTCGCCGTCGGTCAGGATCGCCACGATCGTCGACTCGGTCGTCAGGTCGGTGTAGGCGCGCCAGTCCGTCAGGCCCGCCGTGTCGACGATCCGCCGGTAGGCCGACACGTCGGTGTGCCCGGTCTTGCGGGCCTGCGCGTCGGCCTTGGCCCGGTTGCGCTGGTCGGCCATCAGCCGGCGGAAGCCGTCCGCGTCGACCTGCAGGCCCTGCTCGGCCGCGATCTCCAGGGTCAGGTCGATCGGGAAGCCGTACGTGTCGTGCAGCTGGAACGCCTTGTCACCCGACAGCGCCGACCGGCCGGCCGACTTCGTCTCCGCGATCGCGGTGTCCAGGATCGTGGTGCCGGCCCGCAGCGTGGCCAGGAACGCGTCCTCCTCGGCGTACGCGTACTGCGAGATGCGGCCGAACTCCTCGGCCACCTCCGGGTACGACGGCGCCATGCAGTCGCGGGCCACCGGCAGCAGCTCCGGCAGCGCCCGGTCCTGGTAGCCGAGCAGCCGCATCGCCCGGATCGCCCGGCGCATGATCCGACGCAGCACGTAGCCGCGCCCCTCGTTCGACGGCGTCACCCCGTCGCCGATCAGCATCAGCGCGGTACGCACGTGGTCGGCGACCACCCGCAGCCGCACGTCGTCCGGGTGCGACTGGTTGGCCGCGTGCCCGGAGTGCGCGCCGTAACGCTTGCCGGTCAGCTCGGCCGCCCGGTCCAGGATCGGCTTGACCTCGTCGATCTCGTAGAGGTTGTCCACACCCTGCAGCAGCGAGGCCATCCGCTCCAGGCCCATGCCGGTGTCGATGTTCTTCGCCGGCAGGTCGCCGAGGATCGGGAAGTCCTCCTTGCCGACGCCCGGTCCGCGCTCGAACTGCATGAAGACGAGGTTCCAGAACTCCAGGTAGCGGTCCTCGTCGACCTCCGGGCCACCCTCGCGGCCGTACTCCGGGCCGCGGTCGTAGTAGAGCTCCGAGCACGGGCCGCACGGGCCGGGGATGCCCATCGACCAGAAGTTGTCGGCCTTGCCCCGACGCACGATCCGCTCCGCCGGCACGCCGGTGGCGCGCCAGATGTCGTACGCCTCGTCGTCGTCGAGGTAGACCGTCGCCCAGATTCGCTCCGGGTCCAGCCCGAAGCCGCCCGCCTCGACCGACTTGGTGACCAGGTCCCAGGCCAGCGGGATCGCCCCGGACTTGAAGTAGTCACCGAAGGAGAAGTTGCCGTTCATCTGGAAGAACGTGCCGTGCCGGCTGGTCTTGCCCACCTCGTCGATGTCCGGCGTACGGATGCACTTCTGCACGCTCGCCGCCCGCTGGTACGGCGGGGTCTGCTGGCCCAGGAAGTAGGGCACGAACTGCACCATGCCCGCGTTGATGAACAACAGGTTCGGATCACTGATGGCGGGCAGCGGAGCGGACGGCACCACGGCGTGCCCGTTCGCCTCGAAGTAGGCGAGGAACCGCCGCTTGATCTCCGCCGTGCGCATACCGCCCCATCTCTACTGCAAGTCTTTGGCAATTGCATAGTATGGGCGACTGTGCAGACACCGACCGGCACCCCACGACCCATCACCCGATACGGCACCCCGGTGCTGCACCGCCGCTGCGCCGAGGTCACCGTCTTCGACGACGCCCTCACCCAGCTGGTCGCGGACATGTTCGCCAGCATGTACGCCGCGCACGGTGTCGGCCTGGCCGCCAACCAGATCGGCGTCGACGCCCGGATCTTCGTCCTCGACTGCCCCGACGCCACCGGCGCCCACACGACCGCCCACGTGATCAACCCGGTCCTGCACCTATCGGAGCAGCGTGACCTCGCCACGGACTCCGAGGGCTGCCTGTCCGTGCCCGGCCAGTACGCCGAGGTGACCCGTCCGGCCACCGCCACCGTCATCGGCGTCGACCTGCACGGCCGGCCCGTCCGCATCGACGGCACCGGCACGCTCGCCCGCTGCCTGCAGCACGAGGTCGACCACCTCGACGGCCTCGCCTACGTCGACCGGCTCCCCGCCCGCACCCGCAAGCGACTCCTGGCCGCCGCCGCAGAGCACCCCGGGGTGGGCGTCGGCACCGGACAGGACTGACCGGTGCCGATCGTCCTGGGCATCGAGACGTCCTGCGACGAGACCGGCGTCGGCATCGTCGCCGACGGCGTCCTGCTCGGCGACGCCCTCGCCACGAGCATGGACGAGCACGCCCGCTTCGGCGGCGTCGTCCCTGAGATCGCCGCCCGCGCCCACCTGCACGCCATCACCCCGATGGTGCGCCACGCCCTCGACAAGGCCGGGATCGGCTTCGGCGACATCGACGCCGTCGCCGCCACCGCCGGGCCCGGCCTCGCCACGGCGGTGCAGGTAGGCCTTGCCGCCGGCAAGGCCTACGCGCTGACCCTCGGTGTCCCTCTCTACGGCGTGCACCACCTCGCCGGCCACGCCGCCGTGGACATCCTCGACCACGGCCCGCTCCCCGAGCGCAGCATCGCCCTGATCGTCTCCGGCGGCCACACCTCGCTCCTACTCCTGGGTGACCTCGCCCGTGATCCCGTCATCCACCTCGGCGACACCGCCGACGACGCCGCCGGCGAAGCCTTCGACAAGGTCGCCCGCCTGCTCGGCCTGCCCTACCCCGGCGGCCCCGCCATCGACCGGGTCGCCCGTGAAGGTGACCCCACGGCAATCGCCTTTCCCCGCCCGATGACCGGACCGCATGACCCGCCGTACCGATTCTCGTTCTCCGGCCTGAAGACCGCCGTTGCCCGGCATGTCGAGCGGCATCCGGGCCCGCTGCCCATCGCCGACATCGCCGCCTCCTTTCAGGAAGCCGTCGCCGACACCCTCACCCGAAAGGCCGTCACCGCCTGCCGTGACCACAGCGTCGACACCCTGCTGCTCGTCGGCGGGGTCGCCGCCAACAGCCGTGTCCGCGCCCACGCCGAACACCGCTGCGCCGCCGCCGGCATCACCCTGCGCGTCCCCGCACCACGACTGTGCACCGACAACGGCGCCATGATCGCCGCCATCGGCGACCTCCTCGTGCGCGCCGGCATCGCACCGTCACCGCCGACCCTGGGCGCCGACCCCAACGCCCGGCTGACCCATGCCCTGATTCACCAGGATCCGAACTGAACCGCCCGGACGGGAGGCGCCCGTCGACCGGCGGGAACGCCGTAGACCAGTGTGGACCGGCCGGTCGCAGCCCCACCACGCGGACCTCACCGGCCACCCCGACTTTGCCCAATACCTCATCCGACGAGTCCTCGGGGTCTATCACTGCCACCCGGCACGGCCAGCCGAACTCACCACGCTGCTGGCCCACACTCTCGCGGCATCGTAGACTGACGCGGCGAGGTGACTTCGCCGGATCTCGGCAAGGACCTGCCAGACCGGCGAAGCAAGCCCTGAGCAGGACTTACGCCTGGCTGCTGATCTTCGGCAAGCGAGCACAGCAACGCGGGGTGTGCGACCTGGAGAAATGGAAATAGGACAGGAACCTGCAGGCAGTTCGCCGCCAGGTACAGATAGAGCGTCGTCTTAGGAAACCGATGCTCTATCCCCTGAGCTACGAGGGCGCGAGGGCCTAGTCTAGCGACCTGGGGCTTCACCTGGGGTGGCAGGGAGTGGCCCACGTTCCCCGGACCGCCGTTCTCCCAGCCCAGGACCACAGCCCGAGCACACGAACGCCGGTTTGCGACCGGCGGTCGGCCGCGGTGACCCGTGTTGGCACCGGTTCACCCGGGTTGGCATCCGCAGGAGAGCACACACCGCGCACATCATCGAAGATCAACGACGTTCCGTCCGCACGCCAACAGTCGGCGCCGCCACCGTAGACCAGGGAGCGCTCAGCCCGAGGTCGCTCGGACCCGCCGCGAATCTGACCATGATGATCCCCCCAGACGTCCGCACATGCCGAGGAGCCGTACCATCTGCTCGGCTGGTCGTTCGGCGGCATCATGGCCCACGCCTTCGCGACCCGGCTGCGGGCCGCCGGAGAGCCGGTGGATCTGCTCACGATCGTGGACGCGTACCCCGCACCGCCGAATCCCACGCCGCTCGATCCGCGGCACGCGGTTGCTGCCCTGCTGATCTCGCTCGGCATCACCACCGACGCCCTGGAGCTCGACGCGGGCCAGGCCCTCGACCTCGCCACCGCGCAGGGCCACCCCGTCGCCGCACTCGGCCGCGACCGCCTGGCAGCCATGGCGATCACCTTCGCCGCCAACGTGGCATTGCAGGAGCGCTACGCCGTCACCCGATTCACCGGAGACGCCCTGCTCATCGAGAGCGACCTCCGCCACCGGCTCGACTCGGAGGCGCCGGGCTCATGGTCGCCGTTCATCACCGGGTCCGTCGACGTCGTCCGCATCAACGTCCCGCACGGCGCACTGCTGAACCCCGACCCCGCCGCCACCATTGCCGCCGCGGTCACCAACCGCCTGACCCCACTTGGGTAGTCGGCGGTACGCAGCGCGATCGAGCGGTCCAGGCGAGCGGCGTTGAAGTACAACTCGTCCTGCTCGATCAACCACGGGTCGGCGAGGACCTCGAGCGCGCCGGCGCGTAACGCGAACGGCACGATACTGCCCCGTACACATCCGGTCAGCTCTTCCGCGGTCTCAGCCGGTGCCAGCTGACCTCGGCGGCCTCCGGTGGCCCGGGCGACCGCCGCCAGGTCCACGCGGTGCTCCCCGGGGATGACGGTGAGCGCGTACCGGTGTCCCTCGCTGGCACCGTCCACGGAGATGACCATGCATTTGGCCGCCTTGCGTAGCGGGTGGCCACGTAGCCGGCTGGCGGCCACGGTCCGCCCCTCCGGGGCGTGCTCGATCAAGCGATAGCGAACGCGGTGGCGGTCGAGCAGTTCGATCAGTGCGTCGAAGGCGCCGGTGCTGGTCATGCCATTTGTTCCATTTCGCGACGCAGGCTGGCCGGGCGCATGTCGGTTCACACCTGGTCGATGTGCTCAACGCACTCGGTCTGCGTGCCGACGGTGCCGTCCGCGCGCCAGCCGGCCGGCGGCTGCTGCTCGGCGGGCCAGATCGAGTACTGCTCCTCGTCGTTGATGACGACCTGGTAGCGCTTTTCGTCTGACATTGTCGCTCCTTTGAGGTGTGATGGGACCACTGGCTGATGGTGACGTCTTCGGTTGCACGGCGCGGGCTGCTGTCCGTCGCCGGTGGCTGCTCCTGCGGCTCGGTCACGCCGTAGTCCGCCGCGCGAGGAGTGATGCGGCCCAGCAGCAGTGCGCCCGCGCCGATCAACAGGCACGCCACGGCAAGGCCGAACAGGTAGGGCTTGGCGTAGCCGTACCCCAGCGCCGCCCCGGCGATTGCCGGGGCCGCAACCGGGCCGATCTGGTTGGAGAGGCTGAAGATGGCGTTGTAGCGGCCACGAAGACGGTCCGGGGCCAGGTCGTTGATGATGGCCGACAGGGTGGGCGAGAGTAGCGCCTCGCCGATGGCGAACACGCCGAGGGAGAGCACGAGGAGCCCGTCGCGGCCCCAGCCGGTCAGGTGCAGGGTGGCCGGTGCCACGACCAGCACCCAGGTCAGTGCGAAGAACACGGCGGCCAGGCCGGCGACCCGGGTACGCCGCCGACCGCGGGCGAACTTGATGCCGAACAACTGGATCGCGACCAGCACGGTGATGTTGAGGGCGAACGCGAGACCCACCACCCTGGTGGAGGACCCGGCTCCCCCGGTGACCCAGGCCGGGAAGGCCGAGTTGGTGGGCGACAGGGCGAACACCATGAGCAGGCTGTTGAGTAGCAGCGCACCGAGCAGCGCCCGGTCACGGATCACCTGCCGGTACCCGATCCGCTGCCCGGGCTCGGCGACGTCGGGCGCCGCCGACTGCGGAACGGCTAGCACGGTACGCGACAGCACCAGGATCGCCACGGCGAACAGCACGTACGACGCTGCGTCCACCGCCAGGATGGTGATGAACGGACCTTCGGTCTCAGAGACCGTGATCAGACCGCTCAGCAACGCGCCCGCGCCGTAGGCGACATTGGCCGTCATGTATCGCAGCGCGAAGACAGAGCCCCGCTCCGACGCCGGCACGAGCTCCACCAGGAGCGACATGAAGCCGTTCCACATCAGTCCGCTGGCGCATCCGTAGACGATCGCGGAGGCGATCGCCGTGGCCGGCGACGTGGCGACGATGAAACTCGCGATGCCCACACCGCCGATGAGCAGCCCGAGGACGAAGCCCCGCAACGGGCCGACCCGATCGATCAGCGGCCCGCTCAGCGGTGTCGTGACGATGCCCGCCACACCGATGACCCCGAGGATCGCTCCCGCGGCCGGCAACGACAGGCCACGGACCTGATGCAGGTAGATGATGAGGAACGGCATGGTGAGCCCGCTACCGAGGCAAGAAAGCGCGTTCACTCCCAGTGCTACCCACGCCCGCCGCCCGATGGGCGGAATCAGGCCGACGCGTTCAGCGGTCATTGCGCCTTGCCATCCTTAGTTCGTCGTTCCGGTGCCTGCGAGGGACCGCTCCGCCGCTCGGCCGGCGGGGCGGTCGACCCGTCGTGGTCCCGCCTGTCACAGAGATACGATCCGACGCCAAGCATGCTGGGCCTAGCGCAGTAGGCCGAGGGGCATGGGTCGGTTCTGTGAGGATGAGTTGCAGGCGGTTGTCTCCCGGTACGAGGCGACGCGGGCGGCTGCGTTGACCGAGCGGGACGAGCAGCTACGGGCGTTCCGCGCGGCCGGTTGGCGGCCGGTGGATCTGCAGCGGGTCACCGGGTACAGCCGAGAGACCATCCGTCAGGCACTCCGACCGGAAGTCCGACGGGCGACCAACATCAGCCGACGAAGGACCTTACCCCAGCCGCCGGCCGACTACGGGCCCTATGGTGACCGCAAGCCCTACCTGGTGGCCGAAACCCTCGCCCAACTGCAGGGCCCGACCGAAGGCATGGTTACACTCCCGCGTCACCTCGACTGGTCCGGGCACCCCGAGTACGACCTGAACCGGACCGCGCGCCTGGCCAGCATGTACAAGGTGGTGCTCACCGAAGCCAGCACCGTCGAGGATCTGCACACCTGGCTCGCCGCCGACCTCCTCCGGCGACTCTGGCCCACCCTCTGGCTGCCGCCCCAGCTCCGCCAGCGCTGGGAGGACGCCTTCCCCGAACTCGCCGCGACCGTCAACAACGCGACGTAGCCGTGGACCCCTTCCACGAACCGGCTCACCCGCGTGGCCCCGCAGATCGAACACCAAATGACCGCGTACCGAACGCACCTCCTGCCGCATATCGAAAGCCTAGGTCCTCGCAGATCGAAAGTGCGGCCGTTATGATGGTGCCGTGCCCACACCGCACCTGATCCCCCGCCGCGCCGCCGCGCAGGTCGATGCCGCTCTGGCGGACACCCGCGTCGTCTTGATCAGCGGAGCACGCCAAGCAGGCAAGAGCACCCTGGTCCGCCTCGTTGCCGGCGATCGTCTGGCCGAGCGCCGCGATCTTGATCGGGCTCAGGACCGGGCAGCGGCGATCGCCGATCCCGTCGGGTTCGTGGACTCCTCCGAACTCCTTGTCATCGACGAGATCCAACGCGCTCCGGAACTCCTGTTGGCCATCAAGGCTGCCGTCGACGAGGATCCCCGTCCTGGCCGGTACCTGCTCACCGGATCATCACGGCTGTTCGGCATGGTGGCTGCCCCGGACGCGTTGCCCGGCCGGATGGAGACCGTGGAGCTCTGGCCGTTCTCCCAAGGCGAACTCGACGCAGCGCCGGACGGATTCGTCGACGCCGTCTTCGCGCTCGGCCCTGACCTACGACACGAATCGGACGTGACCCGCGCCGACTACGCGGCCCGAATCGTGCGCGGCGGCCTACCCGAGGCCACCACCCGCACCGACCCACGCCGCCGCCAACGGTTCCTCGACGCCTACGTCCAGGCGCTCATCGACCGCGACGTCCGGCAACTGTCCGACATCCAGCACAAGGGCGAGCTACGCAAACTGGTACGCCTGCTCGCGGCCAGATCCGCGACCATCATCGCCGCAAACTCCCTCGAATCCGCCCTCGGACTCAGTCGACCGACGATCGCCCGCTACCTCCAAGCCCTGGAAGAGATCTTCCTGATCAAACGGATCCCCGGCTGGTCCCGCAACCTGGGCACCCGCGCCACCGCCGCGCCAAAACTGATCTTCGTCGACTCGGGCATCGCCGCCAACGAGATCGCGACCGACGCCCGGGCACTGCTCCGGCCGGGCGCACCGTTCGGTCCGCTGCTCGAGTCATTTGTCCTGTCCGAGCTGTCCCGGCAGCTCACCTGGTCCGAGCAGTTCGTCGACCTGTCCCACTACCGGGACCAGAGCAGGTACGAAGTCGACGCGGTGCTGGAGAACCGAACCGGCCAGGTGGTCGGAATCGAAGTCAAAGCTGCCACCACCGTCGGACCCGACGACTTCCGCGGTCTACGCCGACTCGCCGACCGCCTCGGCGACGACTTCATCGCCGGCATCGTCCTCTATACCGGAACCTCCACGCTGCCGTTCGGCGACAGACTCCGCGCCATGCCGGTCAGTACCCTGTGGCAGGCTCCTGCCCCGACAGCGGACTGACCTCGCCCGCTGGTCGCTCCTCAGCCGGCCAGGGCCACCGAGGACCGAAAGGCGTGGTCTGCTGATCTTCAGCAAGCGATCGCAACTGGACCGCGCAGCGACCGGCACACGAGACCAAGAAGCGAAGAGCCGCAGGTCATCGGCCTGCGGACACCGACGGAGCGTCGGGTTAGGAGCACACGGACCCCGGTTTGCGACCGGGGTTAGTTTAGGCCGCGGTGACCCGCGTTGGCACCGGTTCACCCGGGTGGCATCCGCTGGAGAGCACACTCGGCGCACATTGCCGAAGATCAACACTGCTCCGTCCACATCCCACCTTCGGGTTCACCTGCGGAGGACCACGGAGGGCTCACACCGGATCCCTCTGGCACCGCCGCGATACTGACGCTCGCCGATTACCTGCGCGTGCACGCGACTCGGCGGGTTCGGATCGGTCGGGTACGGCTGCGTGTTCGCGTCCGACGCGTTCGGGCCGCTGGTGATCCGGCCGCAGGCACGGGCGGGTTGAGCGCCGGGCAGGCGCCCGCACCGGACGCCGAACGGATCGCCCGGCAGGCGAAGCAAGCAGTCACCGGTACCGATGTCGCCACGATGAGCCGGTCCGCCGCGACCCAGGTCCATCCACCGCTACCTCTGTGCCGGGGCGCGTGGAGCGCCGACGCCTTAAAGGCCGAGGTCCGTGACTATGTGGTGGAGCATCTCGGCGGCCCGGACGCCGTGCTGATCATCGACGACACCCAGATGATCAAGAAGGGTGACAAGTCCGTCGGCGTTGCCCCGCAGCACTGCGGTGCGACGAATCAGGTGGAGAACTGCCAGGTCGCGGTCATGCTCACCTATGCCGGCGGCCGGGCACGCGTTCATCGGTCACCGCCCGTATCTGCCGAAACGGTGGACCGACGATCCGGCCCGCTGCCGCGAGGCGGGAATCCCGACCGAGGTCGCGGTCGGCACGAAACTCGACCTGGCGCAAGAGTTGCTCGCCGAGGCGCTCGCCGCGAAGGTGCCGTTCGGCTGGTTCACCATGGACGGCGGTTACGGCCAGTACCCGCAGGTCCGTAACTGGCTGGCCACCGGTCGCCTGCCGTATGTGGTGGCGACCTCGGCAGCGCTGCCGATGACCCAGATCAGCGTGCTGCCCGGAGCGACAGCGATCACCCGCGCCGACGACCTGCTGTCGCGACTGTCCGATGGTGACTGGCAGCGCCGTTCCTGCGGTGCCGACAGCACGGGGCAGCGCTTCTATGACTGGGCCCTGGTCCAACTCGGCGGCAACCTACGCGTCAGCGACGAGACACCCACCGACGGGTACGCCCATACCCTGCTGCTGCGGCGCTCGATCACCGACCCGGACGAGGTCACCAATTTCCTTGCCCACGCTCCGGATCCGAGCCCGGCCGACACGCTCATCCGCGTCGCCGGGACCAGGTGGAAGATCGGGGAGAACAACGAGCAAGGAAAGGATCTCATCGGCATCGCTCAGCATCAGGTGAGGACCTGGAACGCGTGGCACCACACCATCACCGTGTGCATGTTCGCCCACGCCTTCGTCGCCGTCCAGCACGCCGGCCTGCACCACGACACCACGACCAGCACCGCGGATCAGGCCATCGGCCAGGGAAAAGCAGCAGCCCAACGCCAACCCGCCCGGCGGGCCCCGACTGGCTGAGCCCGGACCTGCTCGCCCACGCCACCGTCGCCGACGTCCGCAACCTGCTCGCCCAGACCATGCTGCACGCCCGCCGCGACCGACGCCACAGCCTGCGCAGGCTCGCCTGGCGCCTGAAACACAAGATCCGCGCCCAGATCAGCCACCACCAACGCCGCGGCGACCCACTCCCCACAACCCTCTGAAAATGGGTGAAACGGCCAGCGATCACCCCACCCTGAAAGGTCCGCAGCTGTAGTACATGCTGGTGAACACCCCTGCTGGCCGAGTGGCGTCATCGAGGGCCTCGGTTGGCGCCATGGGGCGAACCACAGAAAGGCCGGCGTCCTAGGTAGACAACACCGATCGCCATGCATCTATGATGGCAACCAGCGCAAAGACTGTGAGACTGTCGCATCAACGGTAGCTAACGGCGCGGAGGTGGGATGGCCCCTGAGGGTGTCGAGCGGACATTGGCGGAGAGGCTAGAGCACCCTGATGATCGGCAGGAACACAGCGCGCAATCGGCGTATCCTCTGGGCCTGCACCTGCCTCACAGCCTTGGCGATGATCGTCCTCTTCAGCCTCGGAACGGACAAGGCTTGCGTCCAGTTCCTTCCCAAGGGGCCCGATTCTCCGCTCTCTTCGGGTATTGGTCTGTCCATCTCACGTACACGGGCAGCGTCAGTGCCGCAGCGTTCGTTCTATTCTGGCGCTCGAAGCACAGGGCGGACCCGAGACTACTTCGCGCGGGTCTCCGGTTCCTAGCGGTCGGATTCGTGGCGGGCCTGGGCTATTCCGTGTTGCGAATAGTCCTTCTCGTTGCTCCCAGAGCGTCGGCCATCACTCTATCGAGACACCAGGGAATCCTGCACGAACTGTCGTTCAGTGCGCTCGATCTCCGTGTCTATCGACGAGTGATCGAGATTCGCGACGGATTGATGGCGCTTCGTAGATACACACCCGTGCACCTGCCGGATGAAGCGATGCGGTTTGTCTCCCTGAGGGAAGTCCCTGCAGATGTATTGGACGTGACGGTGACCGCCTGCATCGTAGAGGTGGCGCGCCGAGCCAAGGTGCACGGTGGTCCGGCACCAGAGTCGGTCGCAGACAGCTCCCATCTCATGAGTGAACTGGCTCAATCAGATGTGCTCGAAGAAGTCGAATCCCTGTGCCGGCTCGCCGAGGTTAATAGCGACCCACTCGTGAAAGAGTTTGCGGATTCTGTACCCATGGACCCGATCAATCAGACGAATCATGGTGCTCCGGAGGTGGCACGCGTGGCAGACGGACGGCCCATGGCGTGATCACCTCAGAACGCCACGAGTTCTGATTCATGGGCGAAATCAATCAAGAGAACGGAATGCGATGACCGCTGACCTGTATGCAGAGTATGCTTTCAACAACGATGTTGTCGAAGCTAAGAACCAGCTACAGTACCTCAGCGACACTGTCGATCCACACACATTCGCCACGTTGGATTCAATCGGCGTGGCACCTGGCTGGGAATGTTGGGACGTCGGTGCCGGCGCGGGCACCGTGTCACATTGGCTGGCCGAACGCGTCGGAGTTGAAGGCCGGGTGTTGGCAACCGATATCAAACCGCAACACATTCCGGCTCGCGAGGGCTTGAACATTGCGCGACATGATGTGCGAACAGACCCCTTCCCGACCGAAACCTTCGACCTGATCCACGCGAGACTCCTGTTGATGCACTTGCCCACCCGCGAGCAAGTCGTATCCCAGCTGGTCCAGGCTTTGAAGCCAGGAGGAGTTCTGGTGATCTCTGACTGGGAGACCAACTATCTCGACCTGATCCTGGACAGTCCTGACGAGACCGGATCGCGAGTGTTCATGAGGTTCCTCGAAATCTGCCGAGCGGGAAGCCCCCTGGTTGGTATCGACCTTCGTTGGGCGGCTCGGGCACATAGTGTCATGCGAAGTGCGGGACTATCTGATGTCACAACCACCACGCATGCAAGCTCCTGGGCTGGTGGAACCGGGGCTTGCGTTCTTCATCGAAGCAACACCTTCCAGCTCGAGTCCAGACTGCTCGAGGACGACTTCACCGAAGAGGAGTTGAGAACTCTGCGGGGTGTGCTTCTAGACCCCCGCTTCGTCATCTCCTCATACCTGATGTTCACCACGCTGGGAAGGAGAGCGCAATAGCCTTCTCCAGGGGTGTCTTCCTGAGCGGTCGAGGCCGTCGACCTACCCGTCTCCCTCTCGGTCAGGATGGTGTGAGACACCCCGTGTGAGTGGGGTGCTGACCTGAGGACGGGGATCGGAGATCCTTGTGTACGTGTCCACTTCATCTGGCAAGCAGCCGGCCACCGGCAGCGGGGCCGACCCGGCGCCGAAGCCGTCGCGGCGGGTCTTCAGCCCGGAGTACAAGCTCGCGATGGTCGCCGAGTACGAGAACGCCCCGAACGGCGAGAAAGGCGCGATCCTGCGCCGGGAAGGCCTGTACTCGTCACACATCATCGAATGGACACGGGCCCGCAACGCCGGGCACCTCGGCCACGTCGACAGCGGCGGGAAAACGGATACCGCCGCCCCCTCTGCGCCACGGGTGAAAAAGTCCGCGGACCAGATCGAGTTGGAGAAGCTGCGCCAGCAGAACGAGAAACTGCGGGCGGACCTGACAAAGACCCGGATGGCGTTGGACATCATGGGAAAAGCGCACGCGCTCTTGGAAGAACTCTCCGGGAGCGCGGACAACGACAACCCGCCGAGGAGATCCTGACCGCCGCGTTCGCCGAGCTGCGCGACGCGGATGTCCCGGTCCAGCGGGCGTGCGCGTTGGCGGGGACCTCGCGGGCGACCCACTACCGGCGGGCGCGGCCGGTCGGACCGCGACACGGGCCGTGGCTGCCCCGGACCCCGCCACCATGGACGCTCAGCACGGCCGAACGTGACCGGGTCCTCGCGGTGTTGAACTCGCCCGGCTACGCCGATCTGGCGATTCCTCAGGTGTGGGCGCGGGAACTCGACGCGGGCCGCTACCACTGCTCCATGTCCACGATGTACCGGATCGCGCGTGCGGCCGGTCAGAGTCGGGAACGACGCCGGCTGGCGACCCACCCACCCCGGGTACGGCCGGAGCTGGTCGCGACCGGGCCCGGTCAGGTGTGGTCCTGGGACATCACCGCGTTGAAGGGGCACGTGAAGGGCGTCTGGTACCGATGCTACGTGATCATCGACATCTACTCCCGCTACGTCGTGGGTTGGCTGGTCGCGGCCGCCGAGGACGCGGTCGTGGCCCGTGACTTCCTCGCCGCCGCGATCGGCCGTAACGGGATCGAGCCGCACACGATCCACGCCGACCGTGGTGGCGCGATGGTGTCGAAGCCGGTGTCGGAGATGCTCGTCAACCTCGGTGTCCTCCGGTCGCATTCCCGACCCCGGACGTCGAATGACAACCCGTACTCGGAGGCGCAGTTCAAGACGATGAAGTATGTGCCGGACTTCCCGGCCAGGTTCGGGTCCCTCGCCGACGCGAGAGCGTTCTGCGACGGGTTCTTCACCGCCTACAATCATGAGCATCGGCATTCCGGGATCGGCTGGCACACCCCGGCGTCGGTGCACTACGGCACCGCGGAGCAGGTTCGTGAGCACCGCCAACGCGCCCTCGACGCCGCCCACGCCGCTCACCCGGACCGGTTCACCCGTCGGCCACGCGCCCCGAAGCTGCCCGAGCAGGCCTGGATCAACCAGCCAACCCAGCAGGCACAAACCGTCTCAACTTGA

Protein sequences of DBSCAN-SWA_4

>NZ_CP022961|5919606:5970478|5952069_5952513_-|WP_095566966.1|DBSCAN-SWA
MSGLRSSQIAAAAGVNLQTLRYYERRGLLAEPERSLGGHRLYPEQAVTVLKVIKAAQRLGFALDEVAGLLEAGQHRHGRRPDAGLQSRARAKLAEVEAKIADLQVIAGTLRAAVDAGCDDLVACAGAPCCPIPFATIAEGASDAEDR
>NZ_CP022961|5919606:5970478|5963108_5963675_+|WP_095566976.1|DBSCAN-SWA
MGRFCEDELQAVVSRYEATRAAALTERDEQLRAFRAAGWRPVDLQRVTGYSRETIRQALRPEVRRATNISRRRTLPQPPADYGPYGDRKPYLVAETLAQLQGPTEGMVTLPRHLDWSGHPEYDLNRTARLASMYKVVLTEASTVEDLHTWLAADLLRRLWPTLWLPPQLRQRWEDAFPELAATVNNAT
>NZ_CP022961|5919606:5970478|5921610_5922684_+|WP_095566942.1|transposase|DBSCAN-SWA
MFVRALSMAEGQRLQKITRTAKNPVKLRRAIVVLMSGQGQPVPDIAYLLKATEDYVRDVVHAFNERGFDALDPKWTGGTPNKINEQTRDWICVIARCDPRFLGQPFTTWSLSKLRDYLIATGQVDTISIETVRRILHERGVTWQTSKTWKASNDPDFTAKMRRVLDLYDHPPAGGRVICVDEFGPLNLQPRPGKAWKPQGKPVRLRATYHRDHGVRHMIASLDLATGRIHYRIRDRKRSSEFLDFLKSLRRRWPGQTLHLILDNFSPHKHPTVRAWCQANDVELVFLPTYSSWLNWIEAEFAALRYFTLNGTDHRTHAEQDAAIGDYIRWHNQQARPKTGYATKSKIRHPDYPFKAA
>NZ_CP022961|5919606:5970478|5943453_5944611_-|WP_095566961.1|DBSCAN-SWA
MPRSVALGLAGAPTVVVEASLRACRDVLARVCDVRGITGGPNGLVEGAFASLDAARLSSAPVAGCVLGSGRRALTSQGIAAIVDRLEAARIDALVLAGGNGTMALLDAVDAESRSRDLSLQTVGIPKTIDNDLLGVDFSPGFGSASRYLRLTVPGIARDHSTMSSIEPIRVVETMGRGTGWLAAAAAAALVLENANLAADLCLIPERSDTTIPQILDAVENALAAQSRAFLVCSEGFPFSGSRDDYRAGNHSTLLLGGVSRRLARMLEAQLGRPARGEVLGTQQRSAYSFASAADLECARLTGEWAGRYVLEGRRGVMAGTRRLKSAPLALAVDPVPLAGVAGRTKPLPEEFWPADLQRQERFGEWLQPIIDDGISGPGRSHDGD
>NZ_CP022961|5919606:5970478|5937724_5938132_+|WP_095566955.1|DBSCAN-SWA
MNLPTVLDLITDRETTTRQHADRLREQITALTSELARLDGELADLATTRTTLRTLAAAEFTADDPTIASGPYQQILHVLGTAPAGMRAKGICLALGVEPSPKNVEGTRAKPKRMVNRHVLTEDEPGVFTLNQKRT
>NZ_CP022961|5919606:5970478|5925578_5926823_+|WP_095566948.1|DBSCAN-SWA
MGSGSLAAWRDRHSWAAVLALLVLAPAIIAPPVGLIVAIPAATAVAVVFIRWPQRGISMITAATAVSAISLTVDIAYPGPPGLALFWLPFEMLALLLLTGMTIRLAGERKALVSGAPCVLTTILLPLRFTLRMDQSVLSGSIIMIALTVFPTAIAIGIGFYLRGQDHKRRQAVSTARRDQRLRVAGDLHDFVAHEVTGIVLEAQAAQLEPLDAERARAIFSHIEVAGLRALESMDQTVRTLRDPNGDSSEDAPPVRVYRLADLPALVDRFSSGTAMTATLDLPAELIHALDPEREAAAYAVVLEALTNVRRHAPRAAEVRVVLRPLPGPELEVLVDNDGRSGSGLVGSRTGGGTGLIGIEERVRALGGHLSAGHTDSGWQVRCAFPAPILAVTAPEPPTLALPPGQPGPYTAWK
>NZ_CP022961|5919606:5970478|5968096_5968897_+|WP_157756951.1|DBSCAN-SWA
MTADLYAEYAFNNDVVEAKNQLQYLSDTVDPHTFATLDSIGVAPGWECWDVGAGAGTVSHWLAERVGVEGRVLATDIKPQHIPAREGLNIARHDVRTDPFPTETFDLIHARLLLMHLPTREQVVSQLVQALKPGGVLVISDWETNYLDLILDSPDETGSRVFMRFLEICRAGSPLVGIDLRWAARAHSVMRSAGLSDVTTTTHASSWAGGTGACVLHRSNTFQLESRLLEDDFTEEELRTLRGVLLDPRFVISSYLMFTTLGRRAQ
>NZ_CP022961|5919606:5970478|5930376_5930649_+|WP_157756940.1|DBSCAN-SWA
MTGGRVTHIGEALAGGAFELPAGDEERGDEPSRSERRAVPSDDQDALEEHRIARLEREVEELRNANEILLRVAGFLIRPRDRPQTGEDHD
>NZ_CP022961|5919606:5970478|5941534_5942455_+|WP_157756944.1|DBSCAN-SWA
MHRIGIIGTGDIARKVYLPLLTGNPDVEIVALTSRTREKAVALARRHRLDVVVDDVGEVLQLKPDIVFIHASTSAHAELVRTCLDAGSHVYVDKPLSESLDETHRLEQQATAQGLLLAVGFNRRFAPMVRAAVEAVPNPTMIISEKHRRSIRPDRPFGTVYNDLIHAIDLACWAGAIPVDAVVQGAGIVDGDHLRAATAVLLASRCHAHVAMNRDAGDDAERLFIAGDAVSATVVNLDMVMVQESGTTTTRTFGSWDGILLRRGFVGLVDHVLNSLGAPEQCLVSATAVLRTHRVADQIARSLTGC
>NZ_CP022961|5919606:5970478|5955323_5957990_-|WP_095566972.1|tRNA|DBSCAN-SWA
MRTAEIKRRFLAYFEANGHAVVPSAPLPAISDPNLLFINAGMVQFVPYFLGQQTPPYQRAASVQKCIRTPDIDEVGKTSRHGTFFQMNGNFSFGDYFKSGAIPLAWDLVTKSVEAGGFGLDPERIWATVYLDDDEAYDIWRATGVPAERIVRRGKADNFWSMGIPGPCGPCSELYYDRGPEYGREGGPEVDEDRYLEFWNLVFMQFERGPGVGKEDFPILGDLPAKNIDTGMGLERMASLLQGVDNLYEIDEVKPILDRAAELTGKRYGAHSGHAANQSHPDDVRLRVVADHVRTALMLIGDGVTPSNEGRGYVLRRIMRRAIRAMRLLGYQDRALPELLPVARDCMAPSYPEVAEEFGRISQYAYAEEDAFLATLRAGTTILDTAIAETKSAGRSALSGDKAFQLHDTYGFPIDLTLEIAAEQGLQVDADGFRRLMADQRNRAKADAQARKTGHTDVSAYRRIVDTAGLTDWRAYTDLTTESTIVAILTDGEPVPAATEGQIVTVVLDVTPFYAESGGQAADAGHLTGTDGAGEVIDVQRPVKGLVAHQVRVTAGHLTVGARLTANVDATWRRGARQAHSGTHVLHAALRQVLGPTALQSGSYNRPGYLRLDFAWPGGLPLATRSEVEDVANQALRDDLPVTAQVMPLTRARELGALALFGETYDEQVRVVEIGGAWSRELCGGTHVAHSSQIGLLALTGESSVGAGHRRVEAVVGLDGLRYLARERDLVTQLAAQLQAPREDLPERITVLLGRAKAAERRADQLARELTAQRARRLAADAVQIDGTLVVSVVAAADEDPRQLAELVRAALAQDRPGVVAVAAPAERGTRLVVATTATTPDALSAVQLVRSALGGRGGGTARLAQGGAPGLTADAALATVAGLIRAG
>NZ_CP022961|5919606:5970478|5938858_5939299_+|WP_095566957.1|DBSCAN-SWA
MSRIKPAEVRFYIDADLLGLARVLAGLRSDVTYPGDPGTVIHKRQRPPCPIASPAVKDSEWIPEVAGRGWLIITRDRHIQEHRLEIAAVREHQAKMVALTAADAGSVFGQLEVVMSRWRDIERCLAEPPPFIYAATRTIMRQIPLT
>NZ_CP022961|5919606:5970478|5954684_5955323_+|WP_157756948.1|DBSCAN-SWA
MPRHDHLSAPAARARPAADPNAEPAPVPRAAVRRPQAFTDSREMVALAVQLANAPPGNTPAEAAVTVGWPGLREVATPADLPLLHQAGRQLREVFAHAGARRDREAVHVLNRLLARHRLRPAIAGTGPADRHLHVAAPGATPAAEHVAAAVWALAVFLCEQGIDRFKTCTEPGCGIVFLDETTNRRRRFCSPRCATRAHVRAHRSRRRTVTR
>NZ_CP022961|5919606:5970478|5922719_5923442_+|WP_095566945.1|DBSCAN-SWA
MNDATIFLVEPGEPEASISQGFANPLDLFNYLSPSAWINSAIADLTGTDVFGWMTDWIGGDWAAMWKFGDALGHLAECLQQIGINIQAGVIALDASWDGNANDAAYRYFSHLASSVSGQQYALTDLRDRYHKAATGAWQMSNQLGNILQALADKAILAGIAAAAGTITAETGIGALAGYGTAALIVTDMLKLINQASIIINTAGTAILSFFGIAIDLIYQGGGGLGSIPLPAVSYTPPAA
>NZ_CP022961|5919606:5970478|5933562_5934774_-|WP_095567668.1|DBSCAN-SWA
MEVWWAWEKVRDNKGAAGIDGQSIADFEQDVQNNLYKIWNRMSSGSYFPPPVKAVEIPKAGGTRTLGVPSVGDRVAQTVVAARLEARMEQIFHRDSYGYRPGRSALQAVERTKERCWRMNWVVDMDIAKFFDSVPWDLVVKAVEANTDQPWIILYVKRWLAAPMVTADGTVIRRERGTPQGSAVSPALANLFLHYALDAWLARTFPDVEFARYVDDAVVHCRTEARAVQVRDAIAERMRQVGLQLHPDKTRIVYCQDSNRRGSYEHTSFTFLGFTFRQRGARNRRGQTFNGFLPARSDAAQMKMNATVRSWKLHYKTNLTLADLARWINPIVRGWMQYYGAFYRSKLHPLLERINAYLMRFLRRKLKRLRSKKKALQHWRRTVEKRRSLFAHWRWVTSLSTVW
>NZ_CP022961|5919606:5970478|5967507_5968035_+|WP_157756950.1|DBSCAN-SWA
MAGLGYSVLRIVLLVAPRASAITLSRHQGILHELSFSALDLRVYRRVIEIRDGLMALRRYTPVHLPDEAMRFVSLREVPADVLDVTVTACIVEVARRAKVHGGPAPESVADSSHLMSELAQSDVLEEVESLCRLAEVNSDPLVKEFADSVPMDPINQTNHGAPEVARVADGRPMA
>NZ_CP022961|5919606:5970478|5919606_5920680_-|WP_095566942.1|transposase|DBSCAN-SWA
MFVRALSMAEGQRLQKITRTAKNPVKLRRAIVVLMSGQGQPVPDIAYLLKATEDYVRDVVHAFNERGFDALDPKWTGGTPNKINEQTRDWICVIARCDPRFLGQPFTTWSLSKLRDYLIATGQVDTISIETVRRILHERGVTWQTSKTWKASNDPDFTAKMRRVLDLYDHPPAGGRVICVDEFGPLNLQPRPGKAWKPQGKPVRLRATYHRDHGVRHMIASLDLATGRIHYRIRDRKRSSEFLDFLKSLRRRWPGQTLHLILDNFSPHKHPTVRAWCQANDVELVFLPTYSSWLNWIEAEFAALRYFTLNGTDHRTHAEQDAAIGDYIRWHNQQARPKTGYATKSKIRHPDYPFKAA
>NZ_CP022961|5919606:5970478|5927073_5927814_+|WP_157756939.1|DBSCAN-SWA
MPPKGKGLLVATLVAAITSGAAGCGNSEATKTESQSFPLPGEVLRIDASEAAVKVISGTGESVDVQRELKGKATDDGNATWTMSGDTLKLGLRCSGIVVSCEGRYTVAVPQGTALRVNASGSAVTLDSLTGDIDASVTDDGTLRVAGPTGKLSLATRGGSITVTSARSTEVTAQTKGDGNIDLGFLMAPERVKATASGSVQVTLPNDSGTYRIVGADSASLASDDKSSRSITVSAADGTASVQRAG
>NZ_CP022961|5919606:5970478|5949491_5950682_-|WP_095566964.1|transposase|DBSCAN-SWA
MAKLWIGVDIGKTHHHVAAVDGDGRLVYSRRVANDETALLTVMAEVSTHGRPVCWAVDVTTGLSALLLTLLWRRQVQVRYVSGPVAFHMAAAFAGENKTDARDAVVIAQTIRMRPDIPILEPSDRLLAELTVLTGYRADLVGQRVATLFRLQELLTGISPALERAVDLNRKAPMMVLACWQTPAAIRHAGVDRITALLRRGHVKNAVQVAEAMVAAARQQTVNLPGQRAAAVVVGQMATEILALEQRIAAVDDLIADQLDQHPLAPIIESMPGMGPLLTAELLVHTAGMTEYDSPTKLAAHAGLAPVSRDSGTVAGNHRPPRRYHRRLRHILWMAAFTAARECPTSRAYYERKRAEGKNHRQAILALARRRVDVLWALIRDRKTFTRPASTIRAAA
>NZ_CP022961|5919606:5970478|5930745_5931408_+|WP_095568136.1|DBSCAN-SWA
MGIRVLIADDQAMVRQGMRRILESQSDISVVGEAADGVAAVELVQSLRPDVLLVDIRMPRMDGLEVTRLVAGSAATRSVKVVVVTTFDLDEYVYPALRYGASGFLLKRSGAVLIIEAVRAAVAGDSMISPSITVRLLKHVTQPSPALPAPTESLTAREVEIAGQVAQGKTNADIAAELFISPGTVKTHVAAIQRKLNVRNRVGVAVYAWEAGYASQPSTD
>NZ_CP022961|5919606:5970478|5939402_5939924_+|WP_095566958.1|DBSCAN-SWA
MTTSARRRVDLPEEPPPADRDQDLRVFMQFEAIANLRWPDDVVRQWLYDHGGHLEFLRDYEDLDLERIRWSLEDVPVAELESIPTGASDQGFLEEVAANHEYWLSKRPQRIQDAWKIQGTWLIPPIMISRNLLHPSNRGLQVIEGRMRTILQGRRSGGLHVADKHSAWVGRPG
>NZ_CP022961|5919606:5970478|5961115_5962954_-|WP_157756949.1|DBSCAN-SWA
MTAERVGLIPPIGRRAWVALGVNALSCLGSGLTMPFLIIYLHQVRGLSLPAAGAILGVIGVAGIVTTPLSGPLIDRVGPLRGFVLGLLIGGVGIASFIVATSPATAIASAIVYGCASGLMWNGFMSLLVELVPASERGSVFALRYMTANVAYGAGALLSGLITVSETEGPFITILAVDAASYVLFAVAILVLSRTVLAVPQSAAPDVAEPGQRIGYRQVIRDRALLGALLLNSLLMVFALSPTNSAFPAWVTGGAGSSTRVVGLAFALNITVLVAIQLFGIKFARGRRRTRVAGLAAVFFALTWVLVVAPATLHLTGWGRDGLLVLSLGVFAIGEALLSPTLSAIINDLAPDRLRGRYNAIFSLSNQIGPVAAPAIAGAALGYGYAKPYLFGLAVACLLIGAGALLLGRITPRAADYGVTEPQEQPPATDSSPRRATEDVTISQWSHHTSKERQCQTKSATRSSSTTRSSTRSGPPSSSRRPAGARTAPSARRPSALSTSTRCEPTCARPACVAKWNKWHDQHRRLRRTDRTARPPPRSLSLDRARPGGADRGRQPATWPPATQGGQMHGHLRGRCQRGTPVRAHRHPRGAPRGPGGGRPGHRRPPRSAGTG
>NZ_CP022961|5919606:5970478|5920852_5921167_+|WP_157756938.1|DBSCAN-SWA
MIDPTSEMQRLAGKFALLLAGIYVLFPFGMAVSTAAGEPIPLWGWPLLLLPAFLFAPAVIAAIRLHRTSDRDIGKRLWWRSLLLACTGFVLVIAVALILGEANS
>NZ_CP022961|5919606:5970478|5969467_5970478_+|WP_095567671.1|transposase|DBSCAN-SWA
MLTAAFAELRDADVPVQRACALAGTSRATHYRRARPVGPRHGPWLPRTPPPWTLSTAERDRVLAVLNSPGYADLAIPQVWARELDAGRYHCSMSTMYRIARAAGQSRERRRLATHPPRVRPELVATGPGQVWSWDITALKGHVKGVWYRCYVIIDIYSRYVVGWLVAAAEDAVVARDFLAAAIGRNGIEPHTIHADRGGAMVSKPVSEMLVNLGVLRSHSRPRTSNDNPYSEAQFKTMKYVPDFPARFGSLADARAFCDGFFTAYNHEHRHSGIGWHTPASVHYGTAEQVREHRQRALDAAHAAHPDRFTRRPRAPKLPEQAWINQPTQQAQTVST
>NZ_CP022961|5919606:5970478|5953552_5954167_-|WP_095566969.1|DBSCAN-SWA
MAVYTLPDLTYDYGALEPAMSGQILELHHDKHHAAYVKGANDGLEQLAEARDKGDFSKLVGLEKTYAFNLSGHVLHTIFWNNLSPDGGDRPDGDLAAAIDEHFGSFDAFAGQLSAATKGVQGSGWGVLAWEPLGQRLIVEQVYDHHGNVGQGSTPLLVFDAWEHAYYLQYKNVRPDYVDRLWNLVNWSDVIARFDAARATSPKI
>NZ_CP022961|5919606:5970478|5951795_5952086_-|WP_157756946.1|DBSCAN-SWA
MPKTVDRVAGRARRVLPSGLTGLAGVACAACCALPLLLAAGVLSGAGWAAAGAWMPGIAVALAALAGAAWWWASRRRHRGGCAGGTSCGCSTGSPA
>NZ_CP022961|5919606:5970478|5927825_5928728_+|WP_095566950.1|DBSCAN-SWA
MLELIDITKIYAGDKRAVDSMTLRMDAGMLGMLGPNGAGKSSLMRIAATVTKPTSGRVLFNGDDVVARPDLLRRTLGYLPQDFGVYPNLTSREFLGYLAAAKGLSARSAKARIDELLAMVNLTEALKRPLGKYSGGMLRRVGIAQALLADPQVIIVDEPTAGLDPEERVRFRNLLSDLAADRVVMLSTHIVSDVESVASDIAIVAQGRLLRRDSPEELLRQVDGQVWEVVVPSDRVSVLQHQYVISRLVRTTAGVRVRLLSPVQPGPDSTRVAPDLEDAYLAVINFAAGRSVDPARAVRR
>NZ_CP022961|5919606:5970478|5932523_5933588_+|WP_157756942.1|DBSCAN-SWA
MRIHLELEDLTRVRMVESASPVLESIFALQMLSGPTNPVFRDWRRQAEVAVGRRLNDVTELLRRHQPVPDLLWLADRETKIPAHGYFAHQGARQRAVPVVFDFCRLAVLPYWSSLRRYLQSYREARGQHVIQRGVDSLLRTLHPLLSWEPPVLTIPDGRDRDVYLSGRGLSFKMSLFLGTTPGLVMDPDAGGSVQLVVPVPVTGETASVLRAPSEDEEGALGALVGHTRAAALQVMADGCTTGELSDRLGISLAGASKHAKVLRKAGLIVTARNGNSSLHSLSSLGLALLKAVTTRASKPRSTDEGRLDGALDIGSALSGGRRESHPPAPTDPGVNLSAHRALVILITRRWRAR
>NZ_CP022961|5919606:5970478|5923443_5923758_+|WP_095566946.1|DBSCAN-SWA
MPRDRLDHDLEEMTGDPAIARDIKKTLRQLADGTGGPTLAELARNVLDGRTTLRSAASSDAYATPLTDAINQFRQWHEQLPPEQRRQILDDTRRRLHQATDNTA
>NZ_CP022961|5919606:5970478|5953281_5953551_-|WP_095566968.1|DBSCAN-SWA
MVSAATPAAAELLQRAAGVIAAKHRGDPAGAEELLAAFPSEQARTLGFYLLADLALGLVRAQSGQSMDDLVRELSLLVATTAGSPPVTP
>NZ_CP022961|5919606:5970478|5928724_5930365_+|WP_095566951.1|DBSCAN-SWA
MIARDITALAVADFRDRIRRPAYVVILVAAVALGYFAAPDSDARWVVMYIGTHRGVYNSAYMGTLIALASALWLTLGGFYVVRNGVSRDESTGVGQLFAATPMRTVSYLTGKFLSNCLVLSSMVGVLAVTALILQLARGEEMSIDPVDLLLPFLIIALPLVAFTAGMALLFETVPLLKGGLGNILWFVVWLAVAIGGQSPDAPLGGIGVHAVAASMAQSMSAQGVDISEGGFSLGLVYLDNPLRTFVWDGLDVTAGYLFGRLAMVLISLLLALVPVWWFARFDPSRRHGTASAPAGGPAAPGTGMPDGTPAGPGELAVGGVAVLARPQAVAPAAGLPRSVPKQGGAYGRLLAGEFRILIQGVSRWWWLGMALIIIAGLALPIGAVTLFALPIAWIWPVLIWSRLGTQRYEYGVDGILGAYPWVRRRLVAEWGAGVLLTAVTGGAPLIRMVAAADNAGVAAWCAGALFIPSLALALGVLSRTQRLFQAVYLLWWYVIINGIAFLDFMGTVRSDGEPAGPSPFLIAAVALVLVAVTFAAGTLRRNARS
>NZ_CP022961|5919606:5970478|5958596_5959628_+|WP_095568137.1|tRNA|DBSCAN-SWA
MVLGIETSCDETGVGIVADGVLLGDALATSMDEHARFGGVVPEIAARAHLHAITPMVRHALDKAGIGFGDIDAVAATAGPGLATAVQVGLAAGKAYALTLGVPLYGVHHLAGHAAVDILDHGPLPERSIALIVSGGHTSLLLLGDLARDPVIHLGDTADDAAGEAFDKVARLLGLPYPGGPAIDRVAREGDPTAIAFPRPMTGPHDPPYRFSFSGLKTAVARHVERHPGPLPIADIAASFQEAVADTLTRKAVTACRDHSVDTLLLVGGVAANSRVRAHAEHRCAAAGITLRVPAPRLCTDNGAMIAAIGDLLVRAGIAPSPPTLGADPNARLTHALIHQDPN
>NZ_CP022961|5919606:5970478|5936891_5937728_+|WP_095565938.1|transposase|DBSCAN-SWA
MGDRKRYPSDVTDEQWELIGPFLQAWKAKRVAVSVSGRPGDYDLREIVNAIFYQNRTGCQWAYLPHDLPPKSATYYYFALWRDDGTDQVIHDLLRCQAREKVGRAEDPSAVVLDTQSIRAANHVPAATTGKDAAKKVSGRKRGLAVDALGLVIAVVITAASVTDNTIGIRLLDKVVEHTPTVSRAWVDAGFKQDLALHGAVLGIDVEVVKRSDTKPGFVPIRKRWIVEQVNGTLMLHRRLVREYESRPESSVSRTLWASTANIVRRLTGTSTPSWRHR
>NZ_CP022961|5919606:5970478|5945184_5948322_+|WP_095566962.1|DBSCAN-SWA
MEHSWLRLAVSHPMWSLTFGEADGQDFLAGGCADSTIRLWKASTGAPVRRLRGHTGAVLSVAVGVVSRRPVLASAGIDGTVRLWDPSEDDAGHRTLQGHVGGVRAVAFGQTDGRTFLASAGADGTVRLWDAEAGVPAAEPLTGHSGTALSVAFGLVGDRYVLASAGDDATVRLWDAETGASLMDPLRRHRGGVRSVAFGQVDGVPFLASASDDGTVQLWDPQAGVPLFGRLTGHSGIVRAVGFTQVADVGLVMSAGIDGTIRMWNPNTGVGYPDHITAPADDLRAIAFGKVRGEDVLAIGSGQGVSMSLLADQIDTTKLLAPDIVRSAIVTADAIDAADYFGRVILARHLHGVIGQLIAPGGANSHRSVVVSIDGRWGAGKTTLARLLVEEMRNHTPSATPSPSPTETPGRNGRGIAALPRDPVVVNFDAWRESEIAPHWWAVAAAINRGIRSERSLVARIGMTVTGVGRRIARSPASLAAMLIVSVVVFGSMAIRSAAPAQLNQTLTILQTFLTAATALFAVAAVITRSLFWASPALGRLHLRADDNPLGEVADMVTNLRRWSPRTGSSPLVETAAVVMWIIIGTVAGRLIYSRPETVLSNADWSAWVQRHLIAISVALATALVVGLATPVTVRSASRSIWQGSPSSVDWSADPPRSRWYTRPNWRARAVWAVIAGSIVGVAGSVALPEMAGPAWLPLIVLGGLGIAGLVAQLVYVRSPRRRNRRPIVLVMDELDRCSVPTVVAYLETVHTLLKERSPGAPPSLRNGWRDPAPLVVLVLADGRWVRTAFTTEYDAFKDLGSPVRTLGGDFLQKLFDHTVLVPDLTADHVGHLLERITMPAVSAETRTGRWPPAESRPAADAQSTGGPPPDTDARPAQDDPTALAAERERVADDARAAATPKAIERREAHLLASYTMLLPSNPRLIRRVANTWAMLEALKHHVGHDELDDVVVRAAVMYVTFPSLVDTLLDDVRAPALPDRLDDSATETDRESLWLRPDVLAIITREDGSIVSPASIARCYGKAYAPRRSETSGIPEQRNAAKGS
>NZ_CP022961|5919606:5970478|5941097_5941259_-|WP_157756943.1|DBSCAN-SWA
MEPYRAQEVRAWSTWILHHADRVDPRLSREGMPTAPKSERDDLRPYLPAGHCY
>NZ_CP022961|5919606:5970478|5954253_5954706_+|WP_157756947.1|DBSCAN-SWA
MITSRADRVDAALDRLRRAGLRTTLARRAVLDALGDAAVERRHLNAGEVHRRLTGRGLAVELSTVHRVLGQLVDLGVAHAVPVGGAATFGLADHPHHHAVCEGCGGMRQLPVPAVAASVAAAREVGVEMDGGSGGVVVYGRCPACRATTT
>NZ_CP022961|5919606:5970478|5952509_5952857_-|WP_095566967.1|DBSCAN-SWA
MTTNDEVTGPSWVPEACTLPTAQRPLRLAEFDDLFATALVGQQRPAPTRLRWQLAPAAEATARDLIGRESVCCSFFTFTLAPAGGNGVELEVQVPAGHVDVLDALAARAAAGMAA
>NZ_CP022961|5919606:5970478|5966056_5966749_+|WP_095566979.1|DBSCAN-SWA
MLAEALAAKVPFGWFTMDGGYGQYPQVRNWLATGRLPYVVATSAALPMTQISVLPGATAITRADDLLSRLSDGDWQRRSCGADSTGQRFYDWALVQLGGNLRVSDETPTDGYAHTLLLRRSITDPDEVTNFLAHAPDPSPADTLIRVAGTRWKIGENNEQGKDLIGIAQHQVRTWNAWHHTITVCMFAHAFVAVQHAGLHHDTTTSTADQAIGQGKAAAQRQPARRAPTG
>NZ_CP022961|5919606:5970478|5963817_5965080_+|WP_095566977.1|DBSCAN-SWA
MPTPHLIPRRAAAQVDAALADTRVVLISGARQAGKSTLVRLVAGDRLAERRDLDRAQDRAAAIADPVGFVDSSELLVIDEIQRAPELLLAIKAAVDEDPRPGRYLLTGSSRLFGMVAAPDALPGRMETVELWPFSQGELDAAPDGFVDAVFALGPDLRHESDVTRADYAARIVRGGLPEATTRTDPRRRQRFLDAYVQALIDRDVRQLSDIQHKGELRKLVRLLAARSATIIAANSLESALGLSRPTIARYLQALEEIFLIKRIPGWSRNLGTRATAAPKLIFVDSGIAANEIATDARALLRPGAPFGPLLESFVLSELSRQLTWSEQFVDLSHYRDQSRYEVDAVLENRTGQVVGIEVKAATTVGPDDFRGLRRLADRLGDDFIAGIVLYTGTSTLPFGDRLRAMPVSTLWQAPAPTAD
>NZ_CP022961|5919606:5970478|5951422_5951761_-|WP_091434208.1|DBSCAN-SWA
MTVARSILLFVVAALFEIGGAWLVWQGWREHRGLWWIAAGVIALGAYGFVATFQPDPNFGRILAAYGGVFVAGSLAWGMVVDKFRPDRWDVIGALICLAGVAVIMYAPRPTG
>NZ_CP022961|5919606:5970478|5960425_5960953_+|WP_095566974.1|DBSCAN-SWA
MLGWSFGGIMAHAFATRLRAAGEPVDLLTIVDAYPAPPNPTPLDPRHAVAALLISLGITTDALELDAGQALDLATAQGHPVAALGRDRLAAMAITFAANVALQERYAVTRFTGDALLIESDLRHRLDSEAPGSWSPFITGSVDVVRINVPHGALLNPDPAATIAAAVTNRLTPLG
>NZ_CP022961|5919606:5970478|5958041_5958587_+|WP_095566973.1|DBSCAN-SWA
MQTPTGTPRPITRYGTPVLHRRCAEVTVFDDALTQLVADMFASMYAAHGVGLAANQIGVDARIFVLDCPDATGAHTTAHVINPVLHLSEQRDLATDSEGCLSVPGQYAEVTRPATATVIGVDLHGRPVRIDGTGTLARCLQHEVDHLDGLAYVDRLPARTRKRLLAAAAEHPGVGVGTGQD
>NZ_CP022961|5919606:5970478|5942462_5943461_-|WP_157756945.1|DBSCAN-SWA
MTKARRARFLGDGVVELAQEMLPDIAAGDVRVAVEVSALCGSDKRPYREGSAVVPGHEIAGRIVAVGGGVPTHRVGERGVVYAPVFCGACASCGVGFTNGCLKLAELVGWQRDGGYATHVDVPAQCFIRVPDAMSLDVAVLGLDTVGTAAHGLRWAIRTQVRAVERVAVIGCGPLGLGVAVMSLEMGLPVPEVFDPVPGRLAAAVGMGARRLRDLDAENQYDLVVEASGSRTGREVAQRLVRPGAVLLALGESDEPFVIPANPRTRRTNLFNLRTFYFPLSEVEANWAALARVGPGLVSVLSSRATLDELPEVFARFYRGELLKPFIRFDSP
>NZ_CP022961|5919606:5970478|5965584_5966142_+|WP_095566978.1|DBSCAN-SWA
MSAGQAPAPDAERIARQAKQAVTGTDVATMSRSAATQVHPPLPLCRGAWSADALKAEVRDYVVEHLGGPDAVLIIDDTQMIKKGDKSVGVAPQHCGATNQVENCQVAVMLTYAGGRARVHRSPPVSAETVDRRSGPLPRGGNPDRGRGRHETRPGARVARRGARREGAVRLVHHGRRLRPVPAGP
>NZ_CP022961|5919606:5970478|5948322_5949081_+|WP_095566963.1|DBSCAN-SWA
MIGYAICSVERTGSTLYSALLEQTGIAGRPVVEPFNAKIQSTAFRHHRFSTYHEYLKFARRQARTPNGIFGINIMWRHLARVVGELERARSWNGETSVQMLQHYLPELTHFVFTRRRDTLAQAVSWAIAYQTDRWKSTDPDLGRTPMYDFPLVDTLHQNVVADNFGWESWFKLNGIEPLRLTYEDLVDDPRREIFRTLEFLGLDTPAELALATHIEKQATDLNHTWRDRYLEDKARNNVIQLPTPWLSDGGA
>NZ_CP022961|5919606:5970478|5931496_5932249_+|WP_157756941.1|DBSCAN-SWA
MRPRKTMALILAAAAAVPTMAGCEEKAKSGPEQSESRSFNLSGTTLKVVATEAAVQIKAGAGGGIDVKRSVRGEIADGDSAMSLDDGTLHLRATCGGVVKDCSAKYTVTVPKGVSLNLDGVGSDVTVTGLRNGLTARLSADASLSANDIAGTMQLRSDGGDITVKRARADTVKAVASNDGNVRLSFAEPPRSVEAKSYGGAVTVVVPTGSATYRVVTAGNSVGKQLESDPRSSRTISAVATDGPVSVRKG
>NZ_CP022961|5919606:5970478|5938151_5938862_+|WP_095566956.1|DBSCAN-SWA
MTHGKVDAWETGTVVSVLEREVFSEAEAARLLRVAQSTLHYWLEGDERKGRRHKPVLRTEPRGGRSVTWAEFVEAGLLREYRRTHRVPMVELRAFIGLLREQFGVPYPLADRRPYVAGKKLVLEAQAEAGLDPEYCLVAAVGNQLLLTPPSAAFVERVTWDGDVAAGWRPDPNPQSPVRILPDVRFGRPSIKGISTEVLWEQDEAGLDVEEIAETYQLDVPDVRWALAYENSQRAA
>NZ_CP022961|5919606:5970478|5921163_5921496_+|WP_095566944.1|DBSCAN-SWA
MTFTVHPEALRTYAAQLDEARQAAEEAKRYITHHGSFSLHDSGLFGKAAPGHRHVMAALDLLLDRLARLTDTSSLALLQVAAGYERTDDQAAARIDASYPAVPRPAPNRD
>NZ_CP022961|5919606:5970478|5924415_5925237_-|WP_095566947.1|transposase|DBSCAN-SWA
MSVTYTAVLPVREHTVDVLAGLLTTERARRGTRAGTRALPCRDQAVLILRWFLDSTRMRQLARDNAISLSTSYDYLHEGIDVLAARSPTLHGALLAAKAAGHDYVNIDGILVETDRCRTPGPTEGVDLWWSGKHDNHGGNVQVVTVPDGWPIWTSGVRPGREHDTTAVRTHAEILPALTAAGSDLRTLGDLGYEGESGTITVAFKKPKNAKLSLVQQQLNKAHNSLRAIAERGNSLLKMTFKALRNVSLNPWRIGKIVAAALAVLHIEHDRTT

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095566942.1|5919606_5920680_-|transposase	IS630 family transposase	NA	NA	NA	NA
WP_157756938.1|5920852_5921167_+	hypothetical protein	NA	NA	NA	NA
WP_095566944.1|5921163_5921496_+	hypothetical protein	NA	NA	NA	NA
WP_095566942.1|5921610_5922684_+|transposase	IS630 family transposase	NA	NA	NA	NA
WP_095566945.1|5922719_5923442_+	hypothetical protein	NA	NA	NA	NA
WP_095566946.1|5923443_5923758_+	hypothetical protein	NA	NA	NA	NA
WP_095566947.1|5924415_5925237_-|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_095566948.1|5925578_5926823_+	two-component sensor histidine kinase	NA	NA	NA	NA
WP_157756939.1|5927073_5927814_+	hypothetical protein	NA	NA	NA	NA
WP_095566950.1|5927825_5928728_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.4e-19	30.7
WP_095566951.1|5928724_5930365_+	hypothetical protein	NA	NA	NA	NA
WP_157756940.1|5930376_5930649_+	hypothetical protein	NA	NA	NA	NA
WP_095568136.1|5930745_5931408_+	response regulator transcription factor	NA	NA	NA	NA
WP_157756941.1|5931496_5932249_+	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_157756942.1|5932523_5933588_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_095567668.1|5933562_5934774_-	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_095565938.1|5936891_5937728_+|transposase	IS5 family transposase	NA	NA	NA	NA
WP_095566955.1|5937724_5938132_+	hypothetical protein	NA	NA	NA	NA
WP_095566956.1|5938151_5938862_+	DUF433 domain-containing protein	NA	NA	NA	NA
WP_095566957.1|5938858_5939299_+	hypothetical protein	NA	NA	NA	NA
WP_095566958.1|5939402_5939924_+	hypothetical protein	NA	NA	NA	NA
WP_157756943.1|5941097_5941259_-	hypothetical protein	NA	NA	NA	NA
WP_157756944.1|5941534_5942455_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_157756945.1|5942462_5943461_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_095566961.1|5943453_5944611_-	hypothetical protein	NA	NA	NA	NA
WP_095566962.1|5945184_5948322_+	hypothetical protein	NA	NA	NA	NA
WP_095566963.1|5948322_5949081_+	hypothetical protein	NA	NA	NA	NA
WP_095566964.1|5949491_5950682_-|transposase	IS110 family transposase	NA	NA	NA	NA
WP_091434208.1|5951422_5951761_-	YnfA family protein	NA	NA	NA	NA
WP_157756946.1|5951795_5952086_-	hypothetical protein	NA	NA	NA	NA
WP_095566966.1|5952069_5952513_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_095566967.1|5952509_5952857_-	hypothetical protein	NA	NA	NA	NA
WP_095566968.1|5953281_5953551_-	superoxide dismutase	NA	NA	NA	NA
WP_095566969.1|5953552_5954167_-	superoxide dismutase	NA	NA	NA	NA
WP_157756947.1|5954253_5954706_+	transcriptional repressor	NA	NA	NA	NA
WP_157756948.1|5954684_5955323_+	CGNR zinc finger domain-containing protein	NA	NA	NA	NA
WP_095566972.1|5955323_5957990_-|tRNA	alanine--tRNA ligase	A0A2K9L1X7	Tupanvirus	3.7e-60	34.9
WP_095566973.1|5958041_5958587_+	peptide deformylase	Q6VT21	Vibrio_phage	2.7e-18	42.1
WP_095568137.1|5958596_5959628_+|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	3.3e-57	42.5
WP_095566974.1|5960425_5960953_+	hypothetical protein	NA	NA	NA	NA
WP_157756949.1|5961115_5962954_-	MFS transporter	NA	NA	NA	NA
WP_095566976.1|5963108_5963675_+	hypothetical protein	NA	NA	NA	NA
WP_095566977.1|5963817_5965080_+	ATP-binding protein	NA	NA	NA	NA
WP_095566978.1|5965584_5966142_+	hypothetical protein	NA	NA	NA	NA
WP_095566979.1|5966056_5966749_+	hypothetical protein	NA	NA	NA	NA
WP_157756950.1|5967507_5968035_+	hypothetical protein	NA	NA	NA	NA
WP_157756951.1|5968096_5968897_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_095567671.1|5969467_5970478_+|transposase	IS3 family transposase	NA	NA	NA	NA