CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022379	Capnocytophaga sputigena strain D1179 chromosome, complete genome	2 crisprs	DEDDh,cas3,cas9,WYL,PD-DExK	0	7	1	0

1. NZ_CP022379

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022379_1

• CRISPR_ID: NZ_CP022379_1
• CRISPR_location: 1354222-1355104
• CRISPR_type: TypeII
• Repeat_type: NA
• Spacer_info: 11 spacers
• Cas_protein_info: cas9

Consensus repeat of NZ_CP022379_1

Consensus_repeat	Method
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CRISPRCasFinder
GTTGTGAATTGCTTNTCAAATTTTGTAGTTTTG	CRT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	PILER-CR

spacers of NZ_CP022379_1

>1.1|1354268|31|NZ_CP022379|CRISPRCasFinder
TTTTGAGGTAGGTTACTCCGATAACCAACAG
>1.2|1354345|30|NZ_CP022379|CRISPRCasFinder
CCTGAACCCTGATGACGATGCAAAATTATT
>1.3|1354421|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
CGCCTCTGCCTAATAAGCAACTATGGGTTA
>1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
TAGGTAGAAAAAACAATAAAAAGAATATGA
>1.5|1354573|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
AAGGCGATATGATAGGTGTGATAATGGATG
>1.6|1354649|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
CTCTCCGAGATATGAGTTTCCTTGAAATTA
>1.7|1354725|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
TAAGAGAGTTTTCCAAAGCAGTCCAACGCT
>1.8|1354801|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
TAGCCGAGTTCGGTTTTAGAGTATTGCAAT
>1.9|1354877|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
ATAATACAGTCGTATCTTACAGCAGACTAC
>1.10|1354953|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
CACTGTAGTTCTAAGGTGTTGGGGTCGTAG
>1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR
GAAAAGGCAAAATTATTAACGGAAAATTTA
>1.12|1354254|45|NZ_CP022379|CRT
CGATTGATAACAACTTTTGAGGTAGGTTACTCCGATAACCAACAG
>1.13|1354331|44|NZ_CP022379|CRT
CGATTGATAACAACCCTGAACCCTGATGACGATGCAAAATTATT
>1.14|1354407|44|NZ_CP022379|CRT
TGATTGATAACAACCGCCTCTGCCTAATAAGCAACTATGGGTTA
>1.15|1354483|44|NZ_CP022379|CRT
TGATTGATAACAACTAGGTAGAAAAAACAATAAAAAGAATATGA
>1.16|1354559|44|NZ_CP022379|CRT
TGATTGATAACAACAAGGCGATATGATAGGTGTGATAATGGATG
>1.17|1354635|44|NZ_CP022379|CRT
TGATTGATAACAACCTCTCCGAGATATGAGTTTCCTTGAAATTA
>1.18|1354711|44|NZ_CP022379|CRT
TGATTGATAACAACTAAGAGAGTTTTCCAAAGCAGTCCAACGCT
>1.19|1354787|44|NZ_CP022379|CRT
TGATTGATAACAACTAGCCGAGTTCGGTTTTAGAGTATTGCAAT
>1.20|1354863|44|NZ_CP022379|CRT
TGATTGATAACAACATAATACAGTCGTATCTTACAGCAGACTAC
>1.21|1354939|44|NZ_CP022379|CRT
TGATTGATAACAACCACTGTAGTTCTAAGGTGTTGGGGTCGTAG
>1.22|1355015|44|NZ_CP022379|CRT
TGATTGATAACAACGAAAAGGCAAAATTATTAACGGAAAATTTA

CRISPR arrays and Neighbor proteins around NZ_CP022379_1

CRISPR arrays

The CRISPR arrays of NZ_CP022379_1

>merge|NZ_CP022379|1|1354222-1355104|CRISPRCasFinder,CRT,PILER-CR
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGCGATTGATAACAACTTTTGAGGTAGGTTACTCCGATAACCAACAGTTGTGAATTGCTTTTCAAATTTTGTAGTTTTGCGATTGATAACAACCCTGAACCCTGATGACGATGCAAAATTATTGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACCGCCTCTGCCTAATAAGCAACTATGGGTTAGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACTAGGTAGAAAAAACAATAAAAAGAATATGAGTTGTGAATTGCTTTCAAATCTTGTAGTTTTGTGATTGATAACAACAAGGCGATATGATAGGTGTGATAATGGATGGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACCTCTCCGAGATATGAGTTTCCTTGAAATTAGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACTAAGAGAGTTTTCCAAAGCAGTCCAACGCTGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACTAGCCGAGTTCGGTTTTAGAGTATTGCAATGTTGTGAATTGCTTTCAAATTTCGTAGTTTTGTGATTGATAACAACATAATACAGTCGTATCTTACAGCAGACTACGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACCACTGTAGTTCTAAGGTGTTGGGGTCGTAGGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAACGAAAAGGCAAAATTATTAACGGAAAATTTAGTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC

>NZ_CP022379|1|1|1354222-1355104|CRISPRCasFinder
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGCGATTGATAACAAC	TTTTGAGGTAGGTTACTCCGATAACCAACAG
TTGTGAATTGCTTTTCAAATTTTGTAGTTTTGCGATTGATAACAAC	CCTGAACCCTGATGACGATGCAAAATTATT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CGCCTCTGCCTAATAAGCAACTATGGGTTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	TAGGTAGAAAAAACAATAAAAAGAATATGA
GTTGTGAATTGCTTTCAAATCTTGTAGTTTTGTGATTGATAACAAC	AAGGCGATATGATAGGTGTGATAATGGATG
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CTCTCCGAGATATGAGTTTCCTTGAAATTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	TAAGAGAGTTTTCCAAAGCAGTCCAACGCT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	TAGCCGAGTTCGGTTTTAGAGTATTGCAAT
GTTGTGAATTGCTTTCAAATTTCGTAGTTTTGTGATTGATAACAAC	ATAATACAGTCGTATCTTACAGCAGACTAC
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CACTGTAGTTCTAAGGTGTTGGGGTCGTAG
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	GAAAAGGCAAAATTATTAACGGAAAATTTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC

>NZ_CP022379|1|1|1354222-1355090|CRT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	CGATTGATAACAACTTTTGAGGTAGGTTACTCCGATAACCAACAG
TTGTGAATTGCTTTTCAAATTTTGTAGTTTTG	CGATTGATAACAACCCTGAACCCTGATGACGATGCAAAATTATT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACCGCCTCTGCCTAATAAGCAACTATGGGTTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACTAGGTAGAAAAAACAATAAAAAGAATATGA
GTTGTGAATTGCTTTCAAATCTTGTAGTTTTG	TGATTGATAACAACAAGGCGATATGATAGGTGTGATAATGGATG
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACCTCTCCGAGATATGAGTTTCCTTGAAATTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACTAAGAGAGTTTTCCAAAGCAGTCCAACGCT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACTAGCCGAGTTCGGTTTTAGAGTATTGCAAT
GTTGTGAATTGCTTTCAAATTTCGTAGTTTTG	TGATTGATAACAACATAATACAGTCGTATCTTACAGCAGACTAC
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACCACTGTAGTTCTAAGGTGTTGGGGTCGTAG
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG	TGATTGATAACAACGAAAAGGCAAAATTATTAACGGAAAATTTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTG

>NZ_CP022379|1|1|1354375-1355104|PILER-CR
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CGCCTCTGCCTAATAAGCAACTATGGGTTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	TAGGTAGAAAAAACAATAAAAAGAATATGA
GTTGTGAATTGCTTTCAAATCTTGTAGTTTTGTGATTGATAACAAC	AAGGCGATATGATAGGTGTGATAATGGATG
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CTCTCCGAGATATGAGTTTCCTTGAAATTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	TAAGAGAGTTTTCCAAAGCAGTCCAACGCT
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	TAGCCGAGTTCGGTTTTAGAGTATTGCAAT
GTTGTGAATTGCTTTCAAATTTCGTAGTTTTGTGATTGATAACAAC	ATAATACAGTCGTATCTTACAGCAGACTAC
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	CACTGTAGTTCTAAGGTGTTGGGGTCGTAG
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC	GAAAAGGCAAAATTATTAACGGAAAATTTA
GTTGTGAATTGCTTTCAAATTTTGTAGTTTTGTGATTGATAACAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022379.1|WP_002682272.1|1367541_1368228_-|hypothetical-protein	unknown	unknown	gnl|CDD|380191
NZ_CP022379.1|WP_095898361.1|1349496_1350135_-|leucyl/phenylalanyl-tRNA--protein-transferase	unknown	unknown	gnl|CDD|234720
NZ_CP022379.1|WP_095898364.1|1352141_1352519_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898365.1|1352592_1352844_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl|CDD|225170
NZ_CP022379.1|WP_095898363.1|1351065_1351392_+|YtxH-domain-containing-protein	unknown	unknown	gnl|CDD|378938
NZ_CP022379.1|WP_095898362.1|1350137_1350689_-|DUF3127-domain-containing-protein	unknown	unknown	gnl|CDD|378639
NZ_CP022379.1|WP_095898371.1|1368279_1370997_-|TonB-dependent-receptor	unknown	unknown	gnl|CDD|366183
NZ_CP022379.1|WP_095898360.1|1348879_1349368_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_002678554.1|1351763_1352012_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898368.1|1353652_1354090_+|hypothetical-protein	unknown	unknown	gnl|CDD|234827
NZ_CP022379.1|WP_157909307.1|1352948_1353491_+|hypothetical-protein	unknown	unknown	gnl|CDD|339723
NZ_CP022379.1|WP_095898376.1|1376751_1377702_-|PhoH-family-protein	unknown	unknown	gnl|CDD|376820
NZ_CP022379.1|WP_002681865.1|1375611_1375998_-|30S-ribosomal-protein-S9	unknown	unknown	gnl|CDD|178888
NZ_CP022379.1|WP_095898374.1|1374689_1375415_-|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_CP022379.1|WP_002678524.1|1351396_1351774_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898370.1|1365675_1367490_-|DNA-binding-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898373.1|1373603_1374566_-|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_CP022379.1|WP_095898369.1|1355234_1359608_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|375967
NZ_CP022379.1|WP_095898372.1|1371313_1373485_-|reprolysin-family-zinc-metalloprotease	unknown	unknown	gnl|CDD|316139
NZ_CP022379.1|WP_095898375.1|1375997_1376453_-|50S-ribosomal-protein-L13	unknown	unknown	gnl|CDD|181703

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022379.1|WP_095898369.1|1355234_1359608_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	2.2e-69	229.4	56.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022379.1|WP_095898374.1|1374689_1375415_-|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	1.05616e-135
NZ_CP022379.1|WP_095898361.1|1349496_1350135_-|leucyl/phenylalanyl-tRNA--protein-transferase	gnl|CDD|234720	PRK00301, aat, leucyl/phenylalanyl-tRNA--protein transferase; Reviewed.	4.61865e-120
NZ_CP022379.1|WP_095898363.1|1351065_1351392_+|YtxH-domain-containing-protein	gnl|CDD|378938	pfam12732, YtxH, YtxH-like protein. This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterized.	2.17727e-13
NZ_CP022379.1|WP_095898362.1|1350137_1350689_-|DUF3127-domain-containing-protein	gnl|CDD|378639	pfam11325, DUF3127, Domain of unknown function (DUF3127). This bacterial family of proteins has no known function. However, it does show distant similarity to pfam00436, with proteins such as Prevotella buccalis HMPREF0650_0099 being similar to both families. This suggests that this family may have a DNA-binding function.	3.91298e-37
NZ_CP022379.1|WP_095898365.1|1352592_1352844_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl|CDD|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.39631e-05
NZ_CP022379.1|WP_095898368.1|1353652_1354090_+|hypothetical-protein	gnl|CDD|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0.00115513
NZ_CP022379.1|WP_157909307.1|1352948_1353491_+|hypothetical-protein	gnl|CDD|339723	pfam16385, DUF4994, Domain of unknown function. This family around 100 residues locates in the C-terminal of some uncharacterized proteins in various Bacteroides and Prevotella species. The function of this family remains unknown.	5.8044e-26
NZ_CP022379.1|WP_095898376.1|1376751_1377702_-|PhoH-family-protein	gnl|CDD|376820	pfam02562, PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.	8.74709e-130
NZ_CP022379.1|WP_002681865.1|1375611_1375998_-|30S-ribosomal-protein-S9	gnl|CDD|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	6.36941e-74
NZ_CP022379.1|WP_095898369.1|1355234_1359608_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl|CDD|375967	pfam18541, RuvC_III, RuvC endonuclease subdomain 3. Cas9 proteins are abundant across the bacterial kingdom, but vary widely in both sequence and size. All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand), and a RuvC nuclease domain required for cleaving the noncomplementary strand (non-target strand), yielding double-strand DNA breaks (DSBs). The crystal structures of type II-A and II-C Cas9 proteins highlight the features in Cas9 enzymes that support their function as RNA-guided endonucleases. Cas9 enzymes adopt a bilobed architecture composed of a nuclease lobe containing juxtaposed RuvC and HNH nuclease domains and a variable alpha-helical lobe likely to be involved in nucleic acid binding. The RuvC domain forms the structural core of the nuclease lobe, a six-stranded beta sheet surrounded by four alpha helices, with all three conserved subdomains (I, II, III) contributing catalytic residues to the active site.	1.01128e-54
NZ_CP022379.1|WP_002682272.1|1367541_1368228_-|hypothetical-protein	gnl|CDD|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	2.80085e-06
NZ_CP022379.1|WP_095898373.1|1373603_1374566_-|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.08644e-103
NZ_CP022379.1|WP_095898371.1|1368279_1370997_-|TonB-dependent-receptor	gnl|CDD|366183	pfam00593, TonB_dep_Rec, TonB dependent receptor. This model now only covers the conserved part of the barrel structure.	3.17869e-11
NZ_CP022379.1|WP_095898372.1|1371313_1373485_-|reprolysin-family-zinc-metalloprotease	gnl|CDD|316139	pfam13583, Reprolysin_4, Metallo-peptidase family M12B Reprolysin-like. This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	6.14328e-21
NZ_CP022379.1|WP_095898375.1|1375997_1376453_-|50S-ribosomal-protein-L13	gnl|CDD|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	3.03295e-92

Protein sequences

>NZ_CP022379.1|WP_095898368.1|1353652_1354090_+|hypothetical-protein
MKKSVQIFLELISAITLYLFINSIAYGDHLVTLPLYLTGVVIMSYLFVRERPQECLQSALRIVLPFTGLMLIAGSLPDAHFSLALIYIVSTGAAFLLGMLIATVSKTYQKIGLSALTFLLVVAIRLSFSAEFQYLIGVHWYTLGS
>NZ_CP022379.1|WP_157909307.1|1352948_1353491_+|hypothetical-protein
MIDNNDAFALIPARYQTVATIFKKAGCAMAAIGKWHLGLGDRSGIDWNKPIPHTPNDIGFDESFIMPATSDRVPYEVAPARDTQPHWTSWVGKDKKGRTYAVQEGLRNVLAVLKGKYKYIEPTAQTMKRAWETGIETGFEGAPQLYDLSVDPAKRHNIAGRQPALVKEFEAVIRGERGRH
>NZ_CP022379.1|WP_095898365.1|1352592_1352844_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGIIATLIIGAIAGWLGGTIYKGSGLGLIGNIIIGILGSGVGYWLLGSVFHISLGEGWIGAILTGAIGAIVILFLINLVFKKK
>NZ_CP022379.1|WP_095898364.1|1352141_1352519_+|hypothetical-protein
MKKIIALVSVICLSLVAFSCSKNDDPADNDLFVGTYKGSISYLNGQEKKAVDNGSVTVVKTGNDYYFRFSDGIEDLKGVSFKKEGDNTLINVDLQDGLKVIRINASSLYILYTTDGKTWTANAKR
>NZ_CP022379.1|WP_002678554.1|1351763_1352012_+|hypothetical-protein
MNNKTYSSFEEIDNEIRLLRLEKEIDRLSLTQQVSASAESLSPKNLLANTWVSLLFNNKRWINIALEYGMQLLAKRYLNKNR
>NZ_CP022379.1|WP_002678524.1|1351396_1351774_+|hypothetical-protein
MAIYSIKETFVEVPTKANSAFNSQFAYYKLVVFRFIAKSSYGLITFFVYAFASLLILFFLSLAGAYAIGEALGSNGLGFAIVGAFYILLSLVVLLFRKKLIERSLLRKLSEIYFKTDPEEEENEQ
>NZ_CP022379.1|WP_095898363.1|1351065_1351392_+|YtxH-domain-containing-protein
MSKTANAVLGLAVGTAIGVGLGILFAPDEGKNTRKKIKDTLRDKSDDLKEQLDNLTESVREKSLELKGSLEEKVDRLFSKASNKSEDIISLLEKKLASLKEEAAKVKK
>NZ_CP022379.1|WP_095898362.1|1350137_1350689_-|DUF3127-domain-containing-protein
MEIQGRIIKINPTQTVGQNGFQRRDVVIMTEEQYPQYIPFDFVQEKCVLLDNFQEGQTVRISFNIRGREWVNPQGETKYIVNLQGWRIENAEIAQNYPPQGQPYPQGYGQPAYPPQGYAQPQYQQAPPQYQQAAPQYQQQVPPQYPPQMPQQQFQSTPQQAFGTPPVQNTPVAPAEPEDDLPF
>NZ_CP022379.1|WP_095898361.1|1349496_1350135_-|leucyl/phenylalanyl-tRNA--protein-transferase
MIYLINDETPFPSPETASEEGIVAFGGNLNPARLVEAYSQGIFPWYNEGDPVLWWCPDPRFVLFPEKLHISKNMRKLLSKAPYRVTYNRCFTEVMQQCATVSRKDQHGTWIHPELIEAYTTLHQQGIAHSVEVWQDETLVGGLYGLQMGKIFCGESMFSKQPNASQYGFITFLQAHPHIALVDCQIHSEYLESLGAEEIPRATFLKLLTINR
>NZ_CP022379.1|WP_095898360.1|1348879_1349368_-|hypothetical-protein
MAILRLNKNAKRIIIVIMVITAIIIARIIISNYYENQKVELSKKCFNDSNIGFYHKEFSFYFPEELELQGAQILQIHNQDTIVIDYRILGHNIVINSPKNLKSEDIIKIILKDAVFTLRDFRNGPRFGGGRVFLGCFLQECVINNRKKICDDAGIFMFFSTL
>NZ_CP022379.1|WP_095898369.1|1355234_1359608_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKHILGLDLGSNSIGWAFVQQDFENKQGKIIATGSRIIPMDQGILGDFEKGNTVSQTAERTTYRSMRRLRERHLLRRERLHRVLHILGFLPPHYDAQIDFTKRFGKFIDNAEPKIAYNNGNFIFMNSFNEMIEDFKKYKPQLFYKKSNGEESKIPYDWTIYYLRKKALSQKITQQELAWLILHFNQKRGYYQLRGEEETENPNKEVAFHSLKVVEVEAEAPNKKGEIWYTIRLENGWIYRRTSKIPLDDWKGKTRDFIVTTDLNDDGTIKVDKEGKEKRSFRAPEENDWNLLKKKTEHDIDFSGKTVGAYIYDHLLQDPNQKIKGKLVRTIERKYYKNELKGILTKQIALQPELFTETLLADCIRELYRKNETQQQNLLSKDFLHLFVEDIIFYQRPLRSKKSTIANCTLEKRSYIDKETNERKDAPIKVCAKSNPYYQEFRALQWLQNLRIYEIETDREVTAEFIETPQDYEALFNFLMSQKEIDNESLLKYFLHAKNPQIKDKAAKSELKKWLTTYRWNYVYDVADNSSKKYPMNETGYDLQRYLQKVEGLPANFLTFDTTYRLWHLLYSVKDKVEFEKALKRFAKKKQLNETSFVESFKNFKPYPNEYGSFSEKAIKKLLPLMRFGNHWDFNRIDVSTQKRIDDLINGVANEDIRTIIREKAEKYQLNSESCFQGLPLWLAQYIVYNRHAEATDIEKWTSVSDLETYLEDFKQHSLRNPIVEQVVTETLRVVRDIWQQYGGGQANFFDEIHIELGRELKKTAEERKQLSNRNQENENTNLRIKKLLAELKEDASIQNVLPYSPVQQELLKIYEEGVFSSTDEIEEDIQKIRKKTEPSKADLQRYKLWLEQKYKSPYTGEVISLTKLFTEEYEIEHIIPQSRYYDDSFSNKVICESAVNKLKTNLLGLEFIQKHHGEKVRVAGNKEVTIFTEEQYKDFVKKHYANNLAKQQKLLLNEIPEKMVARQLNDTRYISKYISEILSKIVRSDEKDEGVNSKNVIPCTGKITTALKQDWGLNDVWNELILPRFERMNQLTQTQLFTSYNDRLQKNLPTVPIEYSQGFQKKRIDHRHHAMDALVIACATREHINYMNNQHALDKNKDKKEKQQSRIDLRTILCEKKNNNWQFKKPWATFTQEAKESLEHIVVSFKQNLRVINKATNYYEKWEEKNGVLVKKKVKQEGTNWAIRKPLHKETVSGKIILDRKISKDKILTATRKTVDITFTEKIISSITDTGIQKILLNYLKYKGSPEVAFSAEGLEELNKNIAQYNEGKKHQPIYKVRIFEEGSKFPLGETGAKATKFVEAAKGTNLFFGVYQGKEKRSYTTIPFNKVIERQKQGLPSVPEHNEKGEPLLFILSPNDLVYVPMEGEIAETIDFNNLSKEQKERIYKTVSFTGNECHFVKSTIASLIKSYDAKSKIGELGSLNKLEVTISGDSRIKEVCIKLKVDRLGNITKA
>NZ_CP022379.1|WP_095898370.1|1365675_1367490_-|DNA-binding-protein
MKLNLLKPTAIALLSLFAITSCVKDDDYEIPNPNGEKPLPPFSGKVVTFDVATAQATNTVVTYGADEAIEGYVISSDEGGNFYQKIYIQNEDKTKGVTVAINKTGLYTDFPLGAKVQLRLKGLTSQINNGGVDFGSGIFQANNGRTSVGRMSEAIAKNHLFDKGGVRKTLAELAKADASINTLKVEANVNQLITLKGVHFKTADVGKEMHQKTNDARQGTDYTLTDAQGNTIPFRTSRYAKFKDEKVPAGTLDITGVLTKFGQNWQFMISNYADIVVVNGGTSTGTQTNTTVETIEASTATAASFVEGKKVKLHGNLTVEGTKAYILFSDGTKIQLYTRNFKNISNENKTNLKENGKEVTVTGTFGKFNNTLQISYEQDSDLVWGASNNNPNPPATVETVEASTATAANFVEGKKVKLHGNLTVEGTKSYIVFSDGTKIQLYIKNFKNLSKESKDNLKINGKEVTVTGTFSKHNTTLQIAYEQDSDLVWGASNNNPNPQPPATVTELDASTATAADFQLNKVVKLTGTIKMINNRSTIVFTTDNTEIQLTTKGYGSLPDDFKTKISTEGKKVIVKGTFIEFKDKKKGTVTKQLKYDSIDDVQFP
>NZ_CP022379.1|WP_002682272.1|1367541_1368228_-|hypothetical-protein
MNKLSIFRKGALALLLATTALVGCSKSNESNSDTEFQGVPYMLLTTNKPVGSNISLTIVAKEADKKDVWIDLNNNGVFDTGSDVRLTAATTTYKLQGNTVRVYGKVTTFKCDRNEVTSLDVTRNAVLERLDMSHNKIKEVNLHNNTQLTYLKVSNLPLVGLDLTNNKKLTELRFNLTFSGEKLKKCASTMHENGGGTVYMNPRITDDPAEKQTMQTLTNKKWKIGNCQ
>NZ_CP022379.1|WP_095898371.1|1368279_1370997_-|TonB-dependent-receptor
MFKKFYLFILLLMSASAFAQWRVEGTVVDELSKKPLEGVKVHVNASAWQVTTNGKGKYALSLPEGEYLIIYSLNGYTRQEQLVSVGGEKITQELPVVSLTADVVQESEQMAVINESELEDDESTADAMSGLLQSSQDVFMRRAAFDFSSAFFKPRGYDSKDVTVLINGIPMNRFENGRAQWNNWGGLNDVTRNQEYSNGLSKSDYTFGGLMGSTYINIRPSLNRAGLRITSSASNRSYTGRLMATYNSGVLRNGLSFMVSASRRFAPQGSWVDGTLYNAYAFSAAVEYQLDDHSSFNLLGMFSPVKRGKSSPLTREALDLFGYQYNPYWGRQMGDKRNSRNRIISEPIFVFSYNYLKNDTRLNIDLGYQFGEIGNTRIAYANAQNPEPNYYKNMPSYYLNQNAGPDFAAAENQKNYILENPQLNWEKLYYANYNNTDKHSTFIVSNDINRERTFSANVNFAMPIHDFIKWTSGLVYRNISSDNFAEIDDLLGGQYFVNYDYFENKPYDANEADMKKQKGDKWNYFYSLKSNVGEAFSQLEFTFKKAELFIAGRYHYTDVQREGKYNYPLYSDSYGKGAMQVQNGVSTKAGITYALTGRHLLQLNVGYFNTPQSLRNIYANIRNSNRLLPNLKNELAYSADASYIFRMPYLKGRLTGFFTEIENTAETNFFYTETAITDEIDKDFVAQTVDGIQKRHFGLEFGAEAQLHPTVKITAAAAIGQYTYINNPSLYISAGDVNKAIDEVKMKNYHVPSGPQQAYSLGLEYRNPKYWWVGATANFLAQNYVSLSALSRTSQFFIDPATKATYSNIDFDKARQLLKQERLDDVFLVNLVGGKSWRVKKTYINLMASVNNLFNTKFLSGGFEQSRTANYGRMLQDNAQGVPSFGNRYFVGYGRTYMLNLAVSL
>NZ_CP022379.1|WP_095898372.1|1371313_1373485_-|reprolysin-family-zinc-metalloprotease
MKHIIYLFLYLSFTTAQAQWNISLPNGETLNLEWQERENSQQNKGIHTFVGYSQNQFVATLVVHPNKEASGSLQWGGITYQLTGSQRAKLSAKELRHHNPNARCGTDTEQHTSHFPSPQNSPTARPITTTTSLMPNDPEGILYLYRLAVLVDYHDFAHTFGSDITQVKNFLLNLETFLNEVYVRDIGLKFSIVDDNRLIIQEAAKQLYNQKSRRDIIENSTEKINELIGDKQYDIGIVIAPGTDATLSGLAFFSGGFRLVRKGGASAIAENATIAHEIGHLFGADHTFKNAYSGNSLYTEPRYGQSLMGYSNNFPDGAFFSLPTAYQIRNGIVNRSYFKDSQRTQLVDRNGNDVSNFNYVYGIKTESSFPTIDRTKLQETYTIPKDTYFQFRIKATSPNNLPIYYTAQLTSRAGVNDPKFLTRKGKTEGNPIIFQTQYSDLGGFIEYTRPNVKGEHLFWVATSNPAPQHFVNYDMVAVKVNIADGKTFAITNGMNDEYQGGDKITLHWQVDPNFFDSNSKVRILLSDDFGKTFKYTLVENTENDGTCEITLPNIEIGTVEWGKQPKIQLPAGVIKVEVIDHIAFAITNVAPYKISNGKSVPNGGFKIKKKTETPSPAEDSKPQQEPEKNIVIYNGVSTENTNNYFMVEGADDNSPIHLLIFDEMGLKVYENEHYGKNGDYFRGNANAKGFIGNNKALHGTYFYIVRYSKRGKEEQQKGFLYVR
>NZ_CP022379.1|WP_095898373.1|1373603_1374566_-|elongation-factor-Ts
MANITAADVNKLRQATGAGMMDCKAALIEAEGDFDKAIEVLRKKGQKVAAKRADRDSKEGAAIAQVNANHTVGAIISLNCETDFVAKNADFVALAKDLADLALTVNSKDELLTLNYKGITVAEKLIEQTGVIGEKIELGAFEKVEAPFVGSYIHHGNKIAAIVGLSAAIADAAEVGKNLAMQIAAMGAETLSYKDFSPEYIAKETEARIAIIEKENEELHRLGKPLKHVPQYVSQAQLTPEVLAKAEADAKAELKAEGKPEQIWDKILPGKIQRFISDNTTLDQEKALLDQVYIYDESKKVSEFVKSKNIEITAFKRVAL
>NZ_CP022379.1|WP_095898374.1|1374689_1375415_-|30S-ribosomal-protein-S2
MANNIEIKDLLDAGVHFGHLTRKWNPNMAPYIYMERNGIHVINLYKTAAKIEEAAEALKKIVASGKKVLFVATKKQAKDVVAEKATSVKMPYITERWPGGMLTNFVTIRKAVKKMSSIDKMKKDGTFDTLSKREKLHVERMREKLEKNLGSIADMSRLPGALFVVDTLREHIAVKEAQKLNIPIFAMVDTNSDPREVDFAIPANDDASKAIEKVLSYITEAVNEGLSSRTADANKEAEATE
>NZ_CP022379.1|WP_002681865.1|1375611_1375998_-|30S-ribosomal-protein-S9
MEVIHTIGRRKTAVARIYLKAGNGTITVNKRELNNYFTTPTLQYKVKQALSLVGAEDAYDVKVNVYGGGITGQAEAVRLAIARALCELNAENRAVLKPEGLLTRDPRMVERKKFGQKKARKRFQFSKR
>NZ_CP022379.1|WP_095898375.1|1375997_1376453_-|50S-ribosomal-protein-L13
MDTLSYKTISANKTTANKKWVLVDADGQTLGRLASKVAKLLRGKYKPDFTPHVDCGDNVIVINAEKINLTGNKWEDKTYLRHTGYPGGQRTTGVKQLLEKHPERIIEKAVKGMLPKTKLGAAVLRNLKVYAGTEHKQEAQQPVTINLNDLK
>NZ_CP022379.1|WP_095898376.1|1376751_1377702_-|PhoH-family-protein
MNELTLELTEVSPQVFCGEDESNIKYIKTLFPKLKIVARGSKLIVFGEEHLLKDFQEQMEKLISYTSKYNRLDERTIDNILSASSPETTEKVREEDVIVHGVNGKVIRPQTQNQVKLVEMMRKNDMVFAVGPAGTGKTYVGVALAVKALKEKQVRRIILTRPAVEAGENLGFLPGDLKEKLDPYMQPLYDALRDMIPHEKLNAFIEAGIIEIAPLAFMRGRTLDNAFVILDEAQNTTHAQMKMFLTRMGRNAKFMITGDPGQIDLPRKVSSGLKEAMLILQNVQGIAFLHLDDKDVVRHPLVRSIIEAYKTIENNE

Crispr_ID: NZ_CP022379_2

• CRISPR_ID: NZ_CP022379_2
• CRISPR_location: 2004753-2004858
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DEDDh

Consensus repeat of NZ_CP022379_2

Consensus_repeat	Method
GAGAAGCTCAGGGCTTTCAGGGAAT	CRISPRCasFinder

spacers of NZ_CP022379_2

>2.1|2004778|56|NZ_CP022379|CRISPRCasFinder
CTCCGATTGTTAATTGTTCATTATTTAATTATGATTCCTGAGTTATGAGAAACTCT

CRISPR arrays and Neighbor proteins around NZ_CP022379_2

CRISPR arrays

The CRISPR arrays of NZ_CP022379_2

>merge|NZ_CP022379|2|2004753-2004858|CRISPRCasFinder
GAGAAGCTCAGGGCTTTCAGGGAATCTCCGATTGTTAATTGTTCATTATTTAATTATGATTCCTGAGTTATGAGAAACTCTGAGAAGATCAGGGCTTTCAGGGAAT

>NZ_CP022379|2|2|2004753-2004858|CRISPRCasFinder
GAGAAGCTCAGGGCTTTCAGGGAAT	CTCCGATTGTTAATTGTTCATTATTTAATTATGATTCCTGAGTTATGAGAAACTCT
GAGAAGATCAGGGCTTTCAGGGAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022379.1|WP_002679268.1|2001498_2002134_-|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NZ_CP022379.1|WP_095898851.1|2006931_2008503_+|Na+/H+-antiporter	unknown	unknown	gnl|CDD|129911
NZ_CP022379.1|WP_095898844.1|1999028_1999721_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225818
NZ_CP022379.1|WP_002679409.1|2000817_2001405_-|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NZ_CP022379.1|WP_095898846.1|2002394_2002985_-|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NZ_CP022379.1|WP_095898843.1|1998523_1998973_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898850.1|2006193_2006832_-|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|187560
NZ_CP022379.1|WP_095898841.1|1990145_1990640_-|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl|CDD|99834
NZ_CP022379.1|WP_095898854.1|2010921_2011974_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898855.1|2011995_2012670_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_CP022379.1|WP_095898847.1|2003352_2003943_-|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NZ_CP022379.1|WP_095898845.1|1999717_2000797_-|histidine-kinase	unknown	unknown	gnl|CDD|225814
NZ_CP022379.1|WP_095899491.1|2009185_2009722_-|DUF4303-domain-containing-protein	unknown	unknown	gnl|CDD|372922
NZ_CP022379.1|WP_095898842.1|1990796_1998251_-|hypothetical-protein	unknown	unknown	gnl|CDD|372639
NZ_CP022379.1|WP_095898853.1|2009747_2010788_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898852.1|2008529_2009093_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898849.1|2004894_2005830_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898857.1|2014284_2014761_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022379.1|WP_095898848.1|2004128_2004719_-|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NZ_CP022379.1|WP_095898856.1|2013337_2014276_-|SIMPL-domain-containing-protein	unknown	unknown	gnl|CDD|377344

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022379.1|WP_095898841.1|1990145_1990640_-|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	1.3e-34	114.4	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022379.1|WP_002679268.1|2001498_2002134_-|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	1.51907e-18
NZ_CP022379.1|WP_095898851.1|2006931_2008503_+|Na+/H+-antiporter	gnl|CDD|129911	TIGR00831, Putative_Na+/H+_exchanger_Rv2287/MT2345/Mb2309., Na+/H+ antiporter, bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds].	3.5339e-84
NZ_CP022379.1|WP_095898844.1|1999028_1999721_-|response-regulator-transcription-factor	gnl|CDD|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	7.44899e-47
NZ_CP022379.1|WP_002679409.1|2000817_2001405_-|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	4.60149e-08
NZ_CP022379.1|WP_095899491.1|2009185_2009722_-|DUF4303-domain-containing-protein	gnl|CDD|372922	pfam14136, DUF4303, Domain of unknown function (DUF4303). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 169 and 192 amino acids in length.	5.83489e-39
NZ_CP022379.1|WP_095898846.1|2002394_2002985_-|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	1.5725e-11
NZ_CP022379.1|WP_095898850.1|2006193_2006832_-|NAD(P)H-binding-protein	gnl|CDD|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.45937e-62
NZ_CP022379.1|WP_095898841.1|1990145_1990640_-|3'-5'-exonuclease	gnl|CDD|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	2.20429e-76
NZ_CP022379.1|WP_095898855.1|2011995_2012670_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.24562e-05
NZ_CP022379.1|WP_095898847.1|2003352_2003943_-|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	6.02876e-11
NZ_CP022379.1|WP_095898845.1|1999717_2000797_-|histidine-kinase	gnl|CDD|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	3.07648e-34
NZ_CP022379.1|WP_095898842.1|1990796_1998251_-|hypothetical-protein	gnl|CDD|372639	pfam13585, CHU_C, C-terminal domain of CHU protein family. The function of this C-terminal domain is not known; there are several conserved tryptophan and asparagine residues.	9.57357e-31
NZ_CP022379.1|WP_095898848.1|2004128_2004719_-|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	2.35994e-11
NZ_CP022379.1|WP_095898856.1|2013337_2014276_-|SIMPL-domain-containing-protein	gnl|CDD|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	1.38293e-07

Protein sequences

>NZ_CP022379.1|WP_095898848.1|2004128_2004719_-|PorT-family-protein
MKKIIILTALIAFTATATAQVKFGVRGGYTLSPVSKSIHTDRYENQAHSESASSCGSAYAGLTAEIPASEKLLFDIGLIYINQVTIGEGSTMLHNINLPIAVKYDISGFRPKVGLYASYIPGVTSFEDEHRSLTKNDLKKFDYGATFGLEYNFFDRFFIEANFNLGLANLLTKDPRHSSDYLRTRSILVGVGYRFN
>NZ_CP022379.1|WP_095898847.1|2003352_2003943_-|PorT-family-protein
MKKIIILTALIAFTATATAQVKFGVRGGYTLSPVSKSIHTDRYENQAHSESASSCGSAYAGLTAEIPASEKLLFDVGLIYINQVTIGEGSTMLHNINLPIAVKYDISGFRPKVGIYASYIPGVTSFEDEHRSLTKNDLKKFDYGATFGLEYNFTEKFFIEANFNLGLANLLKEDPRHSSDYLRNRTLFLGVGYRFN
>NZ_CP022379.1|WP_095898846.1|2002394_2002985_-|PorT-family-protein
MKKIIILTALIAFTATATAQVKFGVRGGYTLSPVSKSIHTDRYENQAHSESASSCGSAYAGLTAEVSASEKWFLDIGLIYINQITIGEGSTMLHNINLPIAVKYDISGFRPKVGIYASYIPGVTSFEDEHRSLTKNDLKKFDYGATFGLEYNFFDRFFIEANFNLGLANLLKEDPRHSSDYLRTRSILVGVGYRFN
>NZ_CP022379.1|WP_002679268.1|2001498_2002134_-|PorT-family-protein
MKKIITFVALIALTATATAQNESMGFGIRGGGSITGYNGKTEANYTNVKYKAGYYVGIFSDSQLLPFLDLRTELLFSSYGAKWEFTQGNEKYSNTLHTQYINLPILARLKIGNLGILAGVQGGILVNKPSLENTFNGRTVKLDRSDFAKFDFGAVVGAEFNVTDHFLIDIRFNQGLVNALNSSNSSVRNLNISSNNNFLNVSYTLGVGYRF
>NZ_CP022379.1|WP_002679409.1|2000817_2001405_-|PorT-family-protein
MKKIITIIALIALTATATAQVKFGVHAGAGIGLMSKDVHDDRYEGQNKTDKEPFSTSSYGGFFVEIPASEKLLLDLGAMYTNYSTIGKGKTMLHRIDVPLAIKYDISGLRPKVGGYVSYIPGVTSFENKYRSLTRKDIEKFDYGALFGLEYNFNEKLFIETNFYLGLANLLTKDPRHSSDYLRTRSILIGVGYRF
>NZ_CP022379.1|WP_095898845.1|1999717_2000797_-|histidine-kinase
MNENPYIFLKNNLFLQFLIADRFRIYRHIVACSSLLLFFILGRQWGDYEGMIDYWDWIEKWLGITATFYLNMYVLIPRFFFKGKLATYIILLTLWVLFMLGSTYYLNFVLWKDYMIGKEIKIASEIPVSVAIFSSMVYIVPFIMTSTLIKIFQVWVKDSERMQELERQATESELQALRSQIQPHFLFNMLNSINTLLYIDPEKASYTITKLSDFLRHLLYQTHEEQVFLSSELRFLNDYLSLEAMRRDDFTYELTYSEKNVQGIQIPPNILLILAENAVKHSVDTLSPTYIYMKCEEKEGLLHFSVRNSVPLEPHRKHKCSGIGLPNLNRRLELLYGERFSLSQERLPQEYIVTLTLPL
>NZ_CP022379.1|WP_095898844.1|1999028_1999721_-|response-regulator-transcription-factor
MNCLIIDDEPLARIGMERLIRQYSNLKVVGTFKNAVGVTDFLKKNEVHLLFLDIEMPGINGLELAKILPEQTLVIFTTAYSQYALESYEVDALDYLVKPITPERFKKAIAKAESYHQLLSEQKTDLEATDAQYISIRANRRNYRIAHSDILYIEALKDYVIIHTFTDRYITWINLKNIHSQLPESVFVRVNKSYVVNTQHITSYTHQFVYIGDTEIPIGRTYEVIDKFGN
>NZ_CP022379.1|WP_095898843.1|1998523_1998973_-|hypothetical-protein
MKKFFLFCLALVGFVATAQTYEFKVVTAVESVVPSGMGRSRLISANDERNYKDFTTTRSEEGDERNKSDRDEIRVKGFDETKLLNFFNLGGIRFQNIAANDALITSKLNAMSEEGWELAFVSSGVESNSGKDDSTGLFITRFVFKRLKK
>NZ_CP022379.1|WP_095898842.1|1990796_1998251_-|hypothetical-protein
MQSLKEQWVKCCTLFLLLFTGMVKGQVVSVLTESPVHIANTADFSAGVVTITFNMPAGKTSGELEVTLPAGIEYAQGLTATGGTVTWKAGSAANKPIFTISGAGTVVTVSFKRKVTKAVLSNPNLGDGLHDSAILKIDGKSSPAKQNETAYQLVRPTLAVQFAGGVTSEDVGTHTRTFDIRNTGNGIVKDVYFSVDYPADVAGNGFWHNNTKLTPMTINGKTVYKVPDVHLANNQYVTITENYTISKCGNAMQNVYYAHWGTNSEIFDTTSKARNIQVKTGTPSIELDEDKNSTYFTWEDGLMGNTLGTFTLKYKNNGKGENPTAYDIVLDLLERWNGQTFVSFKPTNIRLVAADGTELTIPQTAISRPNGTNGKLAIDFSKITALKTNDATYSSKDFGFTDENGDGFRAELKKDAAFTLRFDYIRNQPINCLMSSANKDLSISPFTYLHTKNVCGTTITPKEAPVHSYTFTRLLSSVGDGSKFPIQLFHNVATAGYVIAAYNTTGFAATERIKGNNNKNNDNRFKYQIKLPAGVALKNIKFYKANAYGTSSKAPIDLGNATAGSTFNYTTADTEFGYITFDIVLETCLGNNVNFEYYAWFLDKSEKTNTYSEVPLVCVTNKSIMTICSSPCGLNGPEMLSTKVERADNSYGWTDHNMTTRTQRSQVSELQRQRALYLDDIEVISTGKQLNVTTKNLYYHASFAKGAGVTPKSIIFNTATHSITLQASNSIVTKTTVGERDYFLWNLTSALPSAGIPANGTFTTVATYQLTNGEEKYSNSKDIESGGDSFYYRLNDPTTDTAINAQGFHTAEIHCGAKLYATFYFAGLYSTVATNDYNLSGCEIKDIGGWQVHTARRFNTGGTYFTDEFRPARLVKKVTFTVPSSVNYVDKVTYMYRTKYPNATQIDIPISNFILESDNGTYKVYSYTNPPKGQPGHLPVGEISVDNYYDSYFRPWMQATCKTKVVKNLNEAKAANMLVTSKLEYEDFYYHYAARGGQKITSGEIPEHKTPLYFKEVPSIDITAQTALSVKASKREQILEFKLSNNSFSDAPYSWVSIPNIAGVDILSLTEISSTKAHVYTYTAQSNISGEQMFFLSDKGGNGTIAKGENRYFRVIYRITNCEAPLHTLKLYAGWNCNSNPTSGYQSTCSDKSLTFNITVAKSRKEIEPDANNPGQNKPDKVGTIPMCTATPYSYIINSASEGDIYDAKLVVTQGAGISFSDIEVEYPLNSGIKYNETTGAKRLVHTTVGNVHTFDISSILPGGSLPGSISEPTNAENRKFKLTFKVTPDCDFTAGSSFDIDIEGNNLCGKPAAGDKTRAIIAGITGVTINNYDIKLDDLTYVNGNGSACDTGVTYRTRVTVNASNPAFEIGDNARLRFRIPKGYEFVSGAIQSRSSGTSWADPARKTAEDKDVRNEREISVTVPKGMKNGHSFEYNVTIKQKDNATIDCATPKELSAFTTDTVTGVTCATAQGGKCGTFTVNSSPRRSIVIKNERPSLSFSNVAVSSKAENNKEKITVTYKITNGATASATLTARPVVASLYYDTNNNGEVDANDTKLTTYTSTETLAKGATSAERSFSHLVDANKVCRLLLALKNEDNVCLCGDVVSALPAPTTIEGLTQSFTTCATSSITLAPPAAAATYTGYTWSAVSPADALGYLSANNVATPTFLYNGANITSPLVVTYKLTLKRYHGCEAVQTVTVQVSPQGINLTTPAPLVVNCKNATASITQWLNSASAVDTCGNAASVTHNYDTVKPADLCNNSGIVTVTFVGKDALGNTATQTRTITLVNIDAVDDDFTFTDGSVSTTSTRTVLVNDKVGNQTATIGTVSLTVTTPAVGAAGSATPTLNANGTVTVPAGTKSGTYYIGYRICSTVASISVCDTATATVVVGNPTITADPDTFTITTGTSTKSVLDNDKIGTATATTNTVSISVVTGATPKQAGTNTPTLDSDGKVTVPNNTPAGTYTIVYQICDKLNSGNCATTTATVVVGNPTITADPDTFTITTGTSTKSVLDNDKIGTATATTNTVSISVVTGATPKQPGTNTPTLDSDGKVTVPNNTPAGTYTIVYQICDKLNSGNCATTTATVVVGNPTITADPDTFTITTGTSTKSVLDNDKIGTATATTNTVSISVVTGATPKQAGTNTPTLDSNGKVTVPNNTPAGTYTIVYQICDKLNSGNCATTTATVVVGNPAITADPDTFTITTGTSTKSVLDNDKIGTATATTNTVSISVVTGATPKQPGTNTPTLDSDGKVTVPNNTPAGTYTIVYQICDKLNSGNCATTTATVVVGTTTPTAPVPVAVDDRATTPLNTPVTINVLGNDTPEGATPNVTTNPANGSVSANSDGSIEYRPHTDFAGTDTFVYELCNASGCATATVTVEVIKSIVVYNAISLSSDKNDHFHIAGIESYPNNVVRIYNRWGVKVWEAEHYDNIRNVFKGISNGRVTVEAPNKLPQGTYYYVIEYTDERNQQQSKTGWLYIKK
>NZ_CP022379.1|WP_095898841.1|1990145_1990640_-|3'-5'-exonuclease
MNSFVALDFETANQYRSSVCSIGLVFVENNEIVDTYYQLIKPAPNYYSPFCTQVHGLSQYDTEKAPLFPEVWTEILPKIKDLPLVAHNSMFDEGCLREVLAYYALPQHTNPFFCTLRAARKSLPQLVNHKLDTVSAYFGFDLKQHHHALADAEACAHIALELFK
>NZ_CP022379.1|WP_095898849.1|2004894_2005830_-|hypothetical-protein
MKEIFTFIILFLGVNSFAQISVKTEYISNSKFYDAVSDSNTGDGSAMIYSVGALVPLSMKAPEEDDPYQRPTLWGVGLNGSFVQMYNHHFPVGKELPSQVMNLGATFLHLRPLKERWSMLMALGAGSYTPENRLSSIHIGENVVANGAFVLVWHWRPNIEIGGGVALNNTFGYPMVFPAFYFKYNGAFSDKFTIEVGSIDGLKVALGYNYRENLDFKLIANMGGYSAYLRRNGEKEIFSQQTFVVGLQPEFKIGKHVSIPLTVGGSFIRSGRYRERKLSAMFASEAKNEDGSARSSVFLPALYFAAGVTIK
>NZ_CP022379.1|WP_095898850.1|2006193_2006832_-|NAD(P)H-binding-protein
MKGLIIGATGATGKDLVTQLLADDTYSEVHCFVRKPLALTHPKLHAHVVNFDTPKAWADLLHGDVAFSCLGTTLAVAGSKDAQWCVDYDYQYAFAQQCKANGVPTFVLISAAGATAQSKLFYNRMKGQLEDAVKALDFSCLLIFQPSILIRSNSDRSGENFTVKVFKFLNKLGILKRYRPMPTQILAEKMLSAVYNSPKGTFTFTLDKIFEI
>NZ_CP022379.1|WP_095898851.1|2006931_2008503_+|Na+/H+-antiporter
MVQYFPYLLLLMVAIMLLIMFANRLKVAYPILLVLGGLAISFIPNVPTITLNPDLVLIIFLPPLLYADVFSLSLKEMWKWRRIIFSFAFIVVFITAAAVAWVANMVFPGFSLALGFLLGGVIGSTDAVSASTIMKFVKVPKRISTIIESESLLNDASSLIVFRFAALVVTTGQLVWTDIALNFLWVAIGGTLIGLAVAWVMRKLHKYLPTDANMDVILTFIVPYIMYIVANEVGASGVLAVVAGGMYMSFHLTSILAASTSNKGWAVWDILGFVLNGLAFMLIGLALPEVLIGIEAEGMSLATATNYGLLITGVVVGVRLLSSYGALLITQVMKHFITVADRRNPGFRLPLVLGWAGMRGVLSLAVALSIPLTLENGEPFPHRSLILYITFIVILATLLVQGLSLPALIRWAKFPDYEDHIPEAEAESLIRKSLAQAALDYMQKHYKEGITDSFLLQNQKDIWQYQLDMPKCNTTPEVRKKYLAILRHQRRILQQLNKNPHIDEEQIRNFHRQLNLEEEKWEE
>NZ_CP022379.1|WP_095898852.1|2008529_2009093_-|hypothetical-protein
MLSSNKLNYIEGVQKHAKRVATTTIVLSVIVLTILIVIHTIINHRKLADIIYNPFFLVIVLILSFFFFILYRGRQRALKLQKLIEQMSEEEFLFLLQIQSSLSFHYKHAPTFVLCCEQLYLFTPFKIKNIDPKKVEKVHWHYARGGSLLIEIQSPETTKFEVYNSVYPYFASLIGWYNPNADIENYE
>NZ_CP022379.1|WP_095899491.1|2009185_2009722_-|DUF4303-domain-containing-protein
MTPELQPLGDAIFEAAQKAFLKLFENGEHYYYCVLLTTGEALPPCIAAWSVEALERFVNENAIPQEEIPYYKYSFADSPYYAFGYEEYFQQVKQLFEQRDSLIDYNNEEQWNEEYDLRLAAMVYAMKKLDETGIFAFNQPREQVYINVELMPPDDTDIERALSFNNPDNIEEWLSIFG
>NZ_CP022379.1|WP_095898853.1|2009747_2010788_-|hypothetical-protein
MNEQVRKLYDQAQANYPALKAQIEAQVVRWFWAAGGVGYFSLEPFYFEQNRFPKSKILKEAPKDTDNKYQYGVNGKDEIIVAHSYIGCEGDYYEEFYFREKNQIISYHFDFASKKKCINTKIFIYKDGLLQSIYSAFNNNTWSERTMYYEGNKLIRQEKKGIDYIDNTLLYTYDMSGKLNSITNETGYVYYQKKDKKISYKALSEKAAERYYALLVPTIKAYPVKEPLYCINLSFDYQNILPTRIGFGTESERQEYQKYGKEAKHYLWNTAEYAHTIDIEPNEEDATLFDLFNQETEMQEKSSAATKLLVACAKRLKEECASLGIPSTNDFVIVVGDEEEFFFKKV
>NZ_CP022379.1|WP_095898854.1|2010921_2011974_-|hypothetical-protein
MNEQARKLYDQAQANYPALKAQIEAQVVRWFWASGGVGYFSLEPFYFEQNRFSKSKILKDAPEDSDNKYQYGVNANDEIIVERSYTEFKGQCYETFYFREDSQIISYRFEYSEEKECDNVKIFIYKDGLLQYIYSAFEEHYLEETMYYEGNKLIRRKTKGLDYYSNPIDNTLLYTYDMLGKLNSITNETGYVYYQKKDKKVSYKKLSERVAERFYALLIPAIKAYPIPEPLYCLNIAFDYQYIMPPTIGFGTENKRIEWKESYGKRADSLLWNTADYAHTVEIETDNEDTALFELFNQETEMQERESAATKLLVACAKRLKEEWASLGIPSTDDFVVVVSDIEDSFLKKV
>NZ_CP022379.1|WP_095898855.1|2011995_2012670_-|tetratricopeptide-repeat-protein
MNPIIKQWDTAKSLKRCQYKEALAIYETLCPKVETDLSDTFDRAMFFGDYFGVLADVAQYDKAEAMAAKALKYITENEYTTLNYIFYNYGNMYLHQAKWEEAIPWLEKALNRNSDGWINEKQRAYYGTALGGALFHLGRIEEAEEELLKAVEAGKATVANKDWEPFFYLKELYKQKGDEKLMAKYENMYLTRLKKLKEEELIYPLSEHRANKQALEDWKKLNNP
>NZ_CP022379.1|WP_095898856.1|2013337_2014276_-|SIMPL-domain-containing-protein
MKHLFFSVALVSTMLGFGQASGNLNYQNRGRNSLNNNDYSLDFPTNYEMVVSAKGLANIKADAFVAIFSVVQVGKSAEEATSLMSQRLSPVLSALKAKNMEAFVDMISFVPMYEYETEKKVFSKRTYNEVPMGFELKQNLHIKINEASRLNELITLLANNEIYDLVRMDYYSSQLETIKKELKDKVKSAFAEKQKLYETTLGESFASTEKKIIDGFFHISPTEQYSSYEAYSSASLQGKRAGNVVQANKSTTQYYQPIANRDFDVVLNPIIVEPMIQVVYEMKMSVNHPDKNKAKEALLLTPAGELKKINLP
>NZ_CP022379.1|WP_095898857.1|2014284_2014761_-|hypothetical-protein
MKKLFLLLCVWATLPAVAQTSKDKTLIIDASYLKQGSSYGQLGVHFNYYDSNKLALFAGLAGNFRSENGLVAIPEAQLSAWIRADNERGGFVDIPVLLLRPQLNFSPYYFAPEAGIQIFIFYVKAGYAFPWGKMSDNYPFDTGKFRLSVGAIIPLNIK

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022379_1	1.9|1354877|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354877-1354906	30	NZ_CP027230	Capnocytophaga sp. oral taxon 878 strain F0545 plasmid unnamed1, complete sequence	9473-9502	2	0.933
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	2477749-2477778	5	0.833
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NZ_CP020744	Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence	372839-372868	5	0.833
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NZ_CP028164	Staphylococcus aureus strain CFSAN064038 plasmid pGMI17-006, complete sequence	9512-9541	6	0.8
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NZ_KU521355	Staphylococcus aureus subsp. aureus strain M12/0145 plasmid pSAM12-0145 clone ST22, complete sequence	21881-21910	6	0.8
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_021076	Staphylococcus aureus strain 004-737X plasmid pSA737, complete sequence	19577-19606	6	0.8
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_014023	Bacillus megaterium QM B1551 plasmid pBM700, complete sequence	151881-151910	6	0.8
NZ_CP022379_1	1.2|1354345|30|NZ_CP022379|CRISPRCasFinder	1354345-1354374	30	NZ_CP010024	Paraburkholderia fungorum strain ATCC BAA-463 plasmid pBIL, complete sequence	390217-390246	7	0.767
NZ_CP022379_1	1.2|1354345|30|NZ_CP022379|CRISPRCasFinder	1354345-1354374	30	NC_013793	Bacillus pseudofirmus OF4 plasmid pBpOF4-02, complete sequence	92077-92106	7	0.767
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	MF448557	Lactococcus phage 37201, complete genome	27995-28024	7	0.767
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_048010	Salmonella phage S132, complete genome	59232-59261	7	0.767
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_041832	Campylobacter phage vB_CcoM-IBB_35 clone Contig4, complete sequence	9630-9659	7	0.767
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	MK408758	Campylobacter phage CP20, complete genome	131997-132026	7	0.767
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	FN667789	Campylobacter phage CPt10, complete genome	132191-132220	7	0.767
NZ_CP022379_1	1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1355029-1355058	30	AP018320	Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome	40465-40494	7	0.767
NZ_CP022379_1	1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1355029-1355058	30	NZ_CP035229	Bacillus licheniformis strain SRCM103529 plasmid unnamed1, complete sequence	20250-20279	7	0.767
NZ_CP022379_1	1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1355029-1355058	30	NZ_CP022288	Bacillus subtilis strain SX01705 plasmid pSX01705-1, complete sequence	65075-65104	7	0.767
NZ_CP022379_1	1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1355029-1355058	30	MT773555	Myoviridae sp. isolate BML_3 genomic sequence	138253-138282	7	0.767
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	MN694566	Marine virus AFVG_250M779, complete genome	30167-30196	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	469225-469254	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NZ_AP018408	Lactobacillus plantarum strain SN35N plasmid pSN35N-3, complete sequence	12366-12395	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_002111	Riemerella anatipestifer 10 plasmid pCFC1, complete sequence	2625-2654	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NZ_CP009317	Bacillus cereus 03BB102 plasmid unnamed, complete sequence	61030-61059	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	KY806579	Riemerella anatipestifer strain RA-JX plasmid JX, complete sequence	5375-5404	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	KF669663	Bacillus phage Staley, complete genome	79889-79918	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	MK504443	Lactobacillus phage 521B, complete genome	9655-9684	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	MK504446	Lactobacillus phage SAC12B, complete genome	7838-7867	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	MN693940	Marine virus AFVG_250M588, complete genome	37227-37256	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_012473	Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequence	75864-75893	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	KC465899	Pelagibacter phage HTVC008M, complete genome	54887-54916	8	0.733
NZ_CP022379_1	1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1355029-1355058	30	KU878088	Bacillus phage AR9, complete genome	20357-20386	8	0.733
NZ_CP022379_1	1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1355029-1355058	30	MF360957	Bacillus virus PBS1, complete genome	180905-180934	8	0.733
NZ_CP022379_1	1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354497-1354526	30	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	672247-672276	9	0.7
NZ_CP022379_1	1.6|1354649|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354649-1354678	30	NZ_CP019362	Borrelia turicatae 91E135 isolate Oz1 plasmid cp31, complete sequence	1177-1206	9	0.7
NZ_CP022379_1	1.6|1354649|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354649-1354678	30	NZ_CP019369	Borrelia turicatae 91E135 isolate Oz1 plasmid lpU43, complete sequence	35293-35322	9	0.7
NZ_CP022379_1	1.7|1354725|30|NZ_CP022379|CRISPRCasFinder,PILER-CR	1354725-1354754	30	NZ_LN614828	Legionella fallonii LLAP-10 plasmid II, complete sequence	153638-153667	9	0.7
NZ_CP022379_1	1.20|1354863|44|NZ_CP022379|CRT	1354863-1354906	44	NZ_CP027230	Capnocytophaga sp. oral taxon 878 strain F0545 plasmid unnamed1, complete sequence	9459-9502	10	0.773

1. spacer 1.9|1354877|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP027230 (Capnocytophaga sp. oral taxon 878 strain F0545 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.933

ataatacagtcgtatcttacagcagactac	CRISPR spacer
ataatacagtcgtatcttacggctgactac	Protospacer
********************.** ******

2. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.833

taggtagaaaaaacaataaaaaga-atatga	CRISPR spacer
taggtagaaaacacagtaaaaagatgtacg-	Protospacer
*********** ***.******** .**.* 

3. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP020744 (Bacillus mycoides strain Gnyt1 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.833

taggtagaaaaaacaataaa--aagaatatga	CRISPR spacer
taggtacaaaaaacaataaaacaggagtat--	Protospacer
****** *************  *.**.***  

4. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP028164 (Staphylococcus aureus strain CFSAN064038 plasmid pGMI17-006, complete sequence) position: , mismatch: 6, identity: 0.8

taggtag-aaaaaacaataaaaagaatatga	CRISPR spacer
-acataataaaagacaataaaaagaatatgt	Protospacer
 * .**. ****.***************** 

5. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_KU521355 (Staphylococcus aureus subsp. aureus strain M12/0145 plasmid pSAM12-0145 clone ST22, complete sequence) position: , mismatch: 6, identity: 0.8

taggtag-aaaaaacaataaaaagaatatga	CRISPR spacer
-acataataaaagacaataaaaagaatatgt	Protospacer
 * .**. ****.***************** 

6. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_021076 (Staphylococcus aureus strain 004-737X plasmid pSA737, complete sequence) position: , mismatch: 6, identity: 0.8

taggtag-aaaaaacaataaaaagaatatga	CRISPR spacer
-acataataaaagacaataaaaagaatatgt	Protospacer
 * .**. ****.***************** 

7. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_014023 (Bacillus megaterium QM B1551 plasmid pBM700, complete sequence) position: , mismatch: 6, identity: 0.8

-taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
gtagatgaagaaaa-aataaaaagaatatgc	Protospacer
 ***.*..*.**** *************** 

8. spacer 1.2|1354345|30|NZ_CP022379|CRISPRCasFinder matches to NZ_CP010024 (Paraburkholderia fungorum strain ATCC BAA-463 plasmid pBIL, complete sequence) position: , mismatch: 7, identity: 0.767

cctgaaccctgatgacgatgcaaaattatt	CRISPR spacer
cctgaaccttgatgacgatgcagcagatgt	Protospacer
********.*************. *    *

9. spacer 1.2|1354345|30|NZ_CP022379|CRISPRCasFinder matches to NC_013793 (Bacillus pseudofirmus OF4 plasmid pBpOF4-02, complete sequence) position: , mismatch: 7, identity: 0.767

cctgaaccctgatgacgatgcaaaattatt	CRISPR spacer
attgaaccctgatgacgatgaaagtgaatt	Protospacer
 .****************** **.   ***

10. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MF448557 (Lactococcus phage 37201, complete genome) position: , mismatch: 7, identity: 0.767

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
atgaaagaaaaaaaaataaaaagaataaaa	Protospacer
  *. ******** ************* .*

11. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_048010 (Salmonella phage S132, complete genome) position: , mismatch: 7, identity: 0.767

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aaaatagaaaaaccaataaaaacaatatat	Protospacer
 *..******** ********* *****. 

12. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_041832 (Campylobacter phage vB_CcoM-IBB_35 clone Contig4, complete sequence) position: , mismatch: 7, identity: 0.767

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aagtcaattaaaacaattaaaagaatatga	Protospacer
 ** .*.  ******** ************

13. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MK408758 (Campylobacter phage CP20, complete genome) position: , mismatch: 7, identity: 0.767

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aagtcaattaaaacaattaaaagaatatga	Protospacer
 ** .*.  ******** ************

14. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to FN667789 (Campylobacter phage CPt10, complete genome) position: , mismatch: 7, identity: 0.767

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aagtcaattaaaacaattaaaagaatatga	Protospacer
 ** .*.  ******** ************

15. spacer 1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to AP018320 (Nostoc sp. HK-01 plasmid plasmid2 DNA, complete genome) position: , mismatch: 7, identity: 0.767

gaaaaggcaaaattattaacggaaaattta	CRISPR spacer
acaaaggcaaaattattaactgaaaaaggt	Protospacer
. ****************** *****    

16. spacer 1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP035229 (Bacillus licheniformis strain SRCM103529 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

gaaaaggcaaaattattaacggaaaattta	CRISPR spacer
ttagaggcaaaattattaaaggaaaagaaa	Protospacer
  *.*************** ******   *

17. spacer 1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP022288 (Bacillus subtilis strain SX01705 plasmid pSX01705-1, complete sequence) position: , mismatch: 7, identity: 0.767

gaaaaggcaaaattattaacggaaaattta	CRISPR spacer
ttagaggcaaaattattaaaggaaaagaaa	Protospacer
  *.*************** ******   *

18. spacer 1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MT773555 (Myoviridae sp. isolate BML_3 genomic sequence) position: , mismatch: 7, identity: 0.767

gaaaaggcaaaattattaacggaaaattta	CRISPR spacer
gtaaaggaaaagttattaacggaaaaggag	Protospacer
* ***** ***.**************   .

19. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MN694566 (Marine virus AFVG_250M779, complete genome) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
ataataaaaaaaaaaataaaaagaatatat	Protospacer
  ..**.****** **************. 

20. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
gaggtagaaaaaagaataaaaagttcagat	Protospacer
 ************ *********  .* . 

21. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_AP018408 (Lactobacillus plantarum strain SN35N plasmid pSN35N-3, complete sequence) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
actttagaaaaagcaataaaaagaattcca	Protospacer
    ********.************* . *

22. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_002111 (Riemerella anatipestifer 10 plasmid pCFC1, complete sequence) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aatccagaaagaaccataaaaagaatatct	Protospacer
 *  .*****.*** *************  

23. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP009317 (Bacillus cereus 03BB102 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aaaacggaaagaaaaataaaaagaatatgc	Protospacer
 *....****.** *************** 

24. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to KY806579 (Riemerella anatipestifer strain RA-JX plasmid JX, complete sequence) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aatccagaaagaaccataaaaagaatatct	Protospacer
 *  .*****.*** *************  

25. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to KF669663 (Bacillus phage Staley, complete genome) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
tagttagaaaaaaccataaaaagggagttt	Protospacer
*** ********** ********.. .*  

26. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MK504443 (Lactobacillus phage 521B, complete genome) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
ttattagaaaaaataataaaaataatagtg	Protospacer
* . *********.******** ****  .

27. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MK504446 (Lactobacillus phage SAC12B, complete genome) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
ttattagaaaaaataataaaaataatagtg	Protospacer
* . *********.******** ****  .

28. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MN693940 (Marine virus AFVG_250M588, complete genome) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
tttcaagaaaaaacaataaaataaatatat	Protospacer
*    **************** .*****. 

29. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_012473 (Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequence) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aaaacggaaagaaaaataaaaagaatatgc	Protospacer
 *....****.** *************** 

30. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to KC465899 (Pelagibacter phage HTVC008M, complete genome) position: , mismatch: 8, identity: 0.733

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
attaaagaaaaaacaataaggagaatataa	Protospacer
   . **************..*******.*

31. spacer 1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to KU878088 (Bacillus phage AR9, complete genome) position: , mismatch: 8, identity: 0.733

gaaaaggcaaaattattaacggaaaattta	CRISPR spacer
agtacagcaaaattattaaaggaaaattat	Protospacer
.. * .************* ********  

32. spacer 1.11|1355029|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to MF360957 (Bacillus virus PBS1, complete genome) position: , mismatch: 8, identity: 0.733

gaaaaggcaaaattattaacggaaaattta	CRISPR spacer
agtacagcaaaattattaaaggaaaattat	Protospacer
.. * .************* ********  

33. spacer 1.4|1354497|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 9, identity: 0.7

taggtagaaaaaacaataaaaagaatatga	CRISPR spacer
aaaaatatgaaaataataaaaagaatatga	Protospacer
 *..  . .****.****************

34. spacer 1.6|1354649|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP019362 (Borrelia turicatae 91E135 isolate Oz1 plasmid cp31, complete sequence) position: , mismatch: 9, identity: 0.7

ctctccgagatatgagtttccttgaaatta	CRISPR spacer
tagagcgagatatgagattacttgaaatgt	Protospacer
.    *********** ** ********  

35. spacer 1.6|1354649|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_CP019369 (Borrelia turicatae 91E135 isolate Oz1 plasmid lpU43, complete sequence) position: , mismatch: 9, identity: 0.7

ctctccgagatatgagtttccttgaaatta	CRISPR spacer
tagagcgagatatgagattacttgaaatgt	Protospacer
.    *********** ** ********  

36. spacer 1.7|1354725|30|NZ_CP022379|CRISPRCasFinder,PILER-CR matches to NZ_LN614828 (Legionella fallonii LLAP-10 plasmid II, complete sequence) position: , mismatch: 9, identity: 0.7

taagagagttttccaaagcagtccaacgct	CRISPR spacer
ccccttggtttaccaaagcagtccaaggct	Protospacer
.     .**** ************** ***

37. spacer 1.20|1354863|44|NZ_CP022379|CRT matches to NZ_CP027230 (Capnocytophaga sp. oral taxon 878 strain F0545 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.773

tgattgataacaacataatacagtcgtatcttacagcagactac	CRISPR spacer
gtatgaaaagatacataatacagtcgtatcttacggctgactac	Protospacer
  ** .* *.  **********************.** ******

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1301758 : 1309227	7	Yellowstone_lake_phycodnavirus(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP022379|1301758:1309227|DBSCAN-SWA
TATGAAGATAGCAGTTATAGGCACAGGTTATGTAGGCTTAGTATCAGGCACTTGTTTTGCCGAAATGGGCAATAAAGTAACCTGCGTAGATGTCAATACTGAGAAAATAGCAAAGCTCAAACAAGGGATTATCCCCATCTACGAACCCGGATTGGAAGAAATGGTGCTTAGCAATGTAGCTCATCATACCTTGTTTTTTACAACTGATATAGCCGAAGCTATCAAAGATGCCGAGGTTGCTTTCATTGCTGTGGGAACGCCTATGGGCGATGATGGGTCTGCCGATTTGCAATATGTACTTTCAGTAGCCCAAGCAATAGGCGAAACGATGCAAGGAGAACTCATAGTAGTCGATAAATCTACCGTTCCTGTAGGTACAGCCGACAAAGTGCGTGCTACTGTACAAGCTGCCTTAGATAAACGCGGAGTAAATTACAAATTTCACATAGTTTCCAATCCCGAGTTCTTAAAAGAAGGTAAAGCCATTGAAGACTTTATGAAGCCCGATCGCGTGGTTATAGGAGCGGATAACGAATACGCTTTCAAGAAGATGAAAGAACTCTACAATCCGTTTTATATGCAAAATGAACGGATGATCACAATGGATATCCGCTCAGCTGAAATGACCAAATATGCCGCCAATACAATGCTTGCTACCAAAATATCGTTTATGAACGAGATTGCCAATATCTGTGAACGTGTAGGAGCCGATGTGAACAAAGTGCGTATCGGGATAGGTTCTGATAGCCGTATAGGCTACAGTTTTATTTACCCTGGTTGTGGTTATGGAGGTTCTTGTTTCCCCAAAGATGTATTAGCTTTAAAAAAACTAGCTGAAGAGGTAAACTACAAAGCAGAACTTATTGAGTCTGTCGATAAGGTAAACAACCGACAAAAATATGTGATTGCCCAAAAAGTGATTGCCAAATATGGGGAAGACCTCAGCGGTAAAACCTTTGCTGTATGGGGGCTTTCGTTCAAACCTGAAACCGATGATATGCGTGAAGCACCTGCAATTTATATCATTAAAGAATTGGTGAAACGTGGTGCCAAAGTGCAAGCCTATGACCCCAAAGCAGTACACGAAGCCAAAGTATGTTATTTAAAGGATGTAGAAGTTACTTATGTAGAGAGTAAATATGAAGCCCTAAAAGGAGCTGACGCCCTCATTTTACTTACCGAATGGAAAGAATTCCGCGTCCCTGATTTCGATGAAATAGCTAAATTGCTAAACGAAAAAGTAATCTTTGACGGTCGTAACCAATACAACGCCTTTGAATTACCCCAAAAAGGTTGGGAATATATACAAATAGGAGTTTAAAAAGAGAGTGATGAAAATATTAGTAACAGGAGGAGCTGGCTTTGTAGGCTCAAACCTTTGTGAAGCCCTAGCCAAAGCCCCTCAAAACGATGTCTATTCGTTAGACAATTACTTTACCGGAAGTCGGGACAACCACGTGGAGGGTGTAACCTATATAGAAGGTAGCACCGAACACATTTTTGAGTTGATCAATTTTACACCCGATTTGATATATCATCTAGGGGAATACTCACGAGTAGAGCAAAGTTTTGAGGATATAGACAAAGTCCTTTTGTTCAACAAAATAGGCACCTTAAAAGTGTTAGAGTTCTGTCGTAAACACAGGTGCAAACTGGTCTATGCAGGCAGTAGCACTAAGTTTGGCGATGGCGGAATGGGCAAAGACCAAAGCCCTTATGCTTGGAGCAAATCCTCTAACACCGAACTGATTATCAACTATGGCAATTGGTACAATTTAAATTATGCCATTGTATATTTCTACAATGTCTATGGCAAACGAGAAATACACACCGGTAAATACGCTACTCTCATAGCCCTTTTTACTGAGAAAATGAAAAAGGGCGAACCACTAACAGTAGTGAGTCCTGGTACCCAACAGCGCAATTTCACCCATATAGACGATATCGTCGATGGACTGCTATTAGTAGGACAAAAAGGCAAAGGCGATGGCTACGGCATTGGCAGTCCTGAGACTTATACTGTTTTGGAGATTGCTAAACTATTTGGAGGCGAGATACAAATGCTACCAGAACGCAAAGGCAACCGAATGACTGCCGAAGTGGTTACCCAAAAAACAGAAGAACTTGGCTGGAAAGCTAAGAAACATATAAAAGAGTTTATAAAGAATTTAGCAGATTAACAAGTGAAAATATTAGTAACAGGAGCTGCAGGATTTATTGGTGCCTTTGTTTGCAAAGCTTTATTAGAAAAAGGACATCAAGTGGTTGGGATTGATAATCTCAATAATTACTATGATGTAAATTTAAAATATGGTCGATTAGATTTTTTAGGTATTAAAAAAGAAAAATGTATTGATCATACACTTATTAATAGCGAATTATATTCTACTTTTCAATTTGCAAAAGTAGATATTACAGATAAACAACAATTAGTATCGTTATTTGACAAAGAAAAGTTTGAAGTAGTATGTAATTTGGCCGCTCAAGCAGGAGTGAGATATTCTATTGAAAATCCTGATACTTATATACAATCTAATATAGTAGGCTTCGCTAATCTGTTAGAATGTTGCCGCCATTTTTTGGTAAAACATTTAGTATATGCGAGTAGTTCAAGCGTATATGGAATGAATGCTAAAATACCTTTCTCTGAAACCGACAAAGTAGATGCTCCTGTAAGCTTGTATGCAGCTACTAAAAAGAGTAATGAATTGATGGCATACACCTATACTCATCTATATAAGTTTGCCTCTACAGGATTGCGCTTTTTTACTGTTTATGGACCTTGGGGGCGCCCTGATATGTCGCCTATCTTGTTTGCTAACGCTATTGCACAAGATCAACCTATAAAGGTGTTTAATAGTGGTAATATGGAGCGAGACTTTACCTATATTGATGATATAGTAGTAGGGGTAGTAACTATTATAGAAAAACCTATTACAGAATTTAGACCTATGTACAAAATATATAATATAGGGAATAATAATTCTGTAAAGTTAATGGACTTTATAGCTACTATTGAAAAATATATGGGCAAGGAAGCTAAAAAAGAGATGTATCCTATGCAAATGGGAGATGTACAACGTACTTGGGCTGATGTAAGTGACCTAATGAAAGACTATAACTATAAGCCTTCTACAAGTATAGAAGAAGGTATAAAACAGTTTATAAATTGGTATAAAGAATATTATAAGTAATGAAATATACCATACATCTAAAAAACAACAAAACCTACACTTGTGAAGAGAACACCTCTTTGTTACAAGCCGCTTTGGATAGTGGTATTGCTTTGGAATACTCTTGTCTCAACGCCCGTTGCAGCAGTTGCCGTGTGAAAATACTTGAGGGTGAGGTAGAGAATTTGCAAGATGAACAAGTCCTTACCGCAGAAGAAAAAGCAGCAGGCTATGTACTCTCGTGTAATGTAGTACCTAGATCAGAAGTAGTTTTAGATGTAGAAGACTTGGGAGTAACGTTGCCTAAACCACAAGTAACACCTTGCAAAATCAATAGCATTACAGCCGTAGCCACACATATAGCAGAAGTAGTCTTACGCTTGCCCCCTAAAGTTGATTTTCAGTTTTTAGCAGGGCAATATATAGATATCATCAGAAACGGACAAAAACGCAGTTATTCTATCAGTCATAACCAATGTGAAAATAATGAGTTAACACTATTCATTCGCAATTATGAGGGAGGTTTGTTTAGTCAGTATTGGTTTAGCGAAGCCAAAGCCAACGACCTTTTGCGAATGGAAGGTCCTTTAGGTACCTTTTTCTACCGCAGCAATCCCGCTTGTGAAGAGATTGTATTGTTAGCAACAGGTACGGGGATTGCACCTATCAAAGCAATACTCGATCAATGGCAACAACAACCCGAGCAAGTAAAAGGTAAAAAAATATGGTTACTTTGGGGAGGAAGAAAAAAAGAAGACCTCTTTTGGCAACCCGAAACAACACTATCTAATTTCACCTATATACCCGTGCTCACTCGCGAAGACGAGTGGCAAGGAGCTAAAGGTTATGTACAAGAAATAGCGCTACAGCAACCTATCCATTGGCAAAAAGCACAAGTATATGCTTGTGGTAGTGAAGTGATGATACAAAGCGCCCAAAAGCTCCTCACCCAACAAGGATTAAAAGAAGAAAACTTCTTCTCCGATGCCTTTGTTTAACCCATCAGCGCAAGCTGAAAACATTTGTGGTCAAAAAAATAATTCGATATAAAACACTATGAAAGCAGTAATATTAGCAGGCGGTCTTGGTACACGCCTCAGTGAAGAAACCGCCATACGTCCCAAACCAATGGTAGAAATAGGAGGAATGCCCATCTTGTGGCATATCCTCAAAATCTATTCACACTATGGTATCAACGAGTTCATCATCTGTTGTGGCTACAAAGGATATATCATCAAAGAGTATTTCGCCAATTACTTTATGCACCAATCGGATATCACTTTCGATATGGCAAACAACGAGATGCACGTACACCAAAAACGCGCCGAACCTTGGAAAGTTACCCTTATTGACACAGGGGAACATTCAATGACGGGAGGTCGCCTCAAACGTGTTTTGCAATACATTGAAAACGATGAAGCTTTCTGTTTTACTTATGGCGACGGAGTATCTGATATAGATATCGCTAAATTAGTGGCATTCCATAAAGCACATGGCAAGCAAGCCACCCTCACAGCTGTCTATCCCCCAGGTCGCTTTGGAGCTTTAGATATAATAGACAATCAGATTATGAAGTTTCAAGAAAAACCCAAAGGCGATGGTGCTCTCGTAAACGGAGGTTTCTTTGTGCTTTCTCCTAAAGTGATAGAGCGCATCAAAGACGATAATACAATTTGGGAACAAGAACCTCTCAAAGGATTAGCTGCCGACGGACAGCTGATGAGCTACAAACACGAAGGATTTTGGCAACCAATGGATACCCTTCGCGACAAAATGCTCTTAGAAGAATTATGGCAAAACGATAAAGCTCCTTGGAAAGTATGGCAATAGGAAAAGTAAACCCACAATTTTGGAAAGGCAAACGCGTATTTGTTACAGGGCACACGGGCTTCAAAGGTTCGTGGCTATCACTATGGCTACAACTGATGGGAGCCGAAGTAAAAGGATTTTCATTAGCTCCTCCTACCCAGCCCGCCCTCTTTGAAGTAGCTAAAGTAGGTGACAATATGCAAACTGAAATAGGCGACATTCGCAACCTCCAGCAGCTATCACAAAGCATACGTGCTTTCAATCCCGATGTGCTGTTACACTTAGCTGCCCAACCTTTAGTCCGACTTTCCTACAAAGAACCTGTAGATACGTATAGTACCAATGTAATGGGTACGGTAAACGTTTTAGAAGCAGCTCGTTATGCCTCTAACCTGAAATCAGTAGTAATCATCACTACCGATAAGTGTTATGAGAACCGCGAATGGGAATGGGGCTATCGTGAAAACGAACCTATGGGCGGACACGACCCTTATAGCAATAGCAAAGGCTGTGCTGAGTTAGTAGTCTCTGCCTATCGCCGTTCGTTTTTTTATACTAACGATACCGCAGCAGTAGCCTCAGCCCGTGCAGGTAATGTGATAGGAGGAGGCGATTGGGCTGACGACCGGTTGATACCCGATATCTTGCGTGCTTTCGAAAAACAACAACCTGTAATCATCCGTAACCCACTATCCACGCGTCCGTGGCAACACGTATTAGAACCCCTTTCAGGCTATCTTGTATTAGCCGAACGCTTGTATAATGAAGGCAACGCCTTTGCCGAAGGTTGGAACTTTGGACCTAAGGACGACGATTGCCAGCCTGTACAATGGATATTAGAGAAAATGGTACAATTTTGGGGTGAAGGAGCTCATTATGAATGGGACAAGAGCGAACAGCCTCACGAAGCTAATTTCTTAAAACTCGACTGTTCCAAAGCTGCTACCCGACTCAAATGGCATCCTCAATGGCGACTTGCCGATACTTTAGAGAAAATCGTCCACTGGCATCGCTCTTGGTTACAAGGAGCAGATATGCAAACCCACTGCCTTTACGAAATCAAAGGATATATGGAATCCTAACCCCATCAGCGCAAGCTGAAAACATTCGTGCAATCCGTGGGCAAAAAAAATATCAGCGCAAGCTGAAAACTTTTATAATCAAAAAAGAAAATATGTCATTAGAAACAATTAGAGAAGAAATAGCAAAATTAGTAACCCAATATGCCCAAGAGGCTTACAAACCCAAACCCTTTGAAGCAGGAAAAACAGTAATCCCTCCTTCAGGAAAAGTAATCGGCGAACAAGAACTCCAAAATATGGTAGCTGCCTCTTTAGATGCTTGGCTCACCACAGGACGATTTAACGCCGCTTTTGAACAGAAATTAGCCGCCTTCCTAGGGGTGAAATATTGCATTACTGTAAATTCAGGTTCATCAGCCAACTTAGTAGCTTTCAATACCCTCACTTCTCCTAAATTAGGCGACCGCGCAATCAAAAAAGGTGATGAAGTAATAGGCGTAGCAGCAGGATTCCCTACTACAGTGAACCCTATTATACAGTTTGGAGCTATACCCGTATTTGTAGATGTCGACCTACACACACATAATGTAAACGCCGACCTTATAGAACAAGCTATCACCCCTAAAACCAAGGCGATTATGCTCGCCCATACTTTAGGGAATCCTTTCAACTTAGAGAAAATAAAAGCCCTTTGTGAGAAATATAACCTTTGGCTCGTAGAAGATTGCTGTGATGCCTTAGGTGCTACCTACAACGGACAAAAAGTAGGAACTTTTGGTGATATTGCAACACTTAGCTTCTACCCTGCGCATCATATCACTATGGGCGAGGGAGGGGCAGTATTTACTAACAATGCCGAACTAAAAACCATAGCTGAGTCTTTCCGCGATTGGGGTCGTGATTGCTATTGCGCACCTGGGAAAGATAACACTTGCAACTGTCGCTTCTCACAACAGCACGGCGATTTGCCTTTTGGTTACGACCATAAATATGTGTATTCACATATAGGTTACAACCTAAAAATTAGCGATATGCAAGCCGCTTGTGGCTTAGCACAGTTAGACCGCGTAGAGGAGTTTATAGAAAAACGCCGTAAAAATTTCACCTACCTCAAAGAGCGACTCCAAACGCTTACTGATTTTCTATACCTACCAGAAGCAACCCCAAATAGTGACCCTTCTTGGTTTGGCTTTCCTATTACCCTTAAAGAAAAATCAGGCACTACACGTGTAGACTTGCTCCGCTTCTTAGACCAACAAAGAATAGGCACACGCCTGCTCTTTGCTGGTAACCTCATCAAGCAACCTTATTTCCAAGGAGTAGAATACCGCATCGTAGGCGACCTTACTAATACCGATATCACAATGAACCAAACCTTTTGGGTAGGTATCTATCCCGCCTTAGGTGAGGAAGAATTAGATTACATAGCGGAACAATTAGAGGAATATTTCGGAGTAAATTTCTAA

Protein sequences of DBSCAN-SWA_1

>NZ_CP022379|1301758:1309227|1303940_1304951_+|WP_095898323.1|DBSCAN-SWA
MKILVTGAAGFIGAFVCKALLEKGHQVVGIDNLNNYYDVNLKYGRLDFLGIKKEKCIDHTLINSELYSTFQFAKVDITDKQQLVSLFDKEKFEVVCNLAAQAGVRYSIENPDTYIQSNIVGFANLLECCRHFLVKHLVYASSSSVYGMNAKIPFSETDKVDAPVSLYAATKKSNELMAYTYTHLYKFASTGLRFFTVYGPWGRPDMSPILFANAIAQDQPIKVFNSGNMERDFTYIDDIVVGVVTIIEKPITEFRPMYKIYNIGNNNSVKLMDFIATIEKYMGKEAKKEMYPMQMGDVQRTWADVSDLMKDYNYKPSTSIEEGIKQFINWYKEYYK
>NZ_CP022379|1301758:1309227|1301758_1303078_+|WP_095898321.1|DBSCAN-SWA
MKIAVIGTGYVGLVSGTCFAEMGNKVTCVDVNTEKIAKLKQGIIPIYEPGLEEMVLSNVAHHTLFFTTDIAEAIKDAEVAFIAVGTPMGDDGSADLQYVLSVAQAIGETMQGELIVVDKSTVPVGTADKVRATVQAALDKRGVNYKFHIVSNPEFLKEGKAIEDFMKPDRVVIGADNEYAFKKMKELYNPFYMQNERMITMDIRSAEMTKYAANTMLATKISFMNEIANICERVGADVNKVRIGIGSDSRIGYSFIYPGCGYGGSCFPKDVLALKKLAEEVNYKAELIESVDKVNNRQKYVIAQKVIAKYGEDLSGKTFAVWGLSFKPETDDMREAPAIYIIKELVKRGAKVQAYDPKAVHEAKVCYLKDVEVTYVESKYEALKGADALILLTEWKEFRVPDFDEIAKLLNEKVIFDGRNQYNAFELPQKGWEYIQIGV
>NZ_CP022379|1301758:1309227|1304950_1305928_+|WP_095898324.1|DBSCAN-SWA
MKYTIHLKNNKTYTCEENTSLLQAALDSGIALEYSCLNARCSSCRVKILEGEVENLQDEQVLTAEEKAAGYVLSCNVVPRSEVVLDVEDLGVTLPKPQVTPCKINSITAVATHIAEVVLRLPPKVDFQFLAGQYIDIIRNGQKRSYSISHNQCENNELTLFIRNYEGGLFSQYWFSEAKANDLLRMEGPLGTFFYRSNPACEEIVLLATGTGIAPIKAILDQWQQQPEQVKGKKIWLLWGGRKKEDLFWQPETTLSNFTYIPVLTREDEWQGAKGYVQEIALQQPIHWQKAQVYACGSEVMIQSAQKLLTQQGLKEENFFSDAFV
>NZ_CP022379|1301758:1309227|1305986_1306760_+|WP_095898325.1|DBSCAN-SWA
MKAVILAGGLGTRLSEETAIRPKPMVEIGGMPILWHILKIYSHYGINEFIICCGYKGYIIKEYFANYFMHQSDITFDMANNEMHVHQKRAEPWKVTLIDTGEHSMTGGRLKRVLQYIENDEAFCFTYGDGVSDIDIAKLVAFHKAHGKQATLTAVYPPGRFGALDIIDNQIMKFQEKPKGDGALVNGGFFVLSPKVIERIKDDNTIWEQEPLKGLAADGQLMSYKHEGFWQPMDTLRDKMLLEELWQNDKAPWKVWQ
>NZ_CP022379|1301758:1309227|1306750_1307821_+|WP_095898326.1|DBSCAN-SWA
MAIGKVNPQFWKGKRVFVTGHTGFKGSWLSLWLQLMGAEVKGFSLAPPTQPALFEVAKVGDNMQTEIGDIRNLQQLSQSIRAFNPDVLLHLAAQPLVRLSYKEPVDTYSTNVMGTVNVLEAARYASNLKSVVIITTDKCYENREWEWGYRENEPMGGHDPYSNSKGCAELVVSAYRRSFFYTNDTAAVASARAGNVIGGGDWADDRLIPDILRAFEKQQPVIIRNPLSTRPWQHVLEPLSGYLVLAERLYNEGNAFAEGWNFGPKDDDCQPVQWILEKMVQFWGEGAHYEWDKSEQPHEANFLKLDCSKAATRLKWHPQWRLADTLEKIVHWHRSWLQGADMQTHCLYEIKGYMES
>NZ_CP022379|1301758:1309227|1303088_1303937_+|WP_095898322.1|DBSCAN-SWA
MKILVTGGAGFVGSNLCEALAKAPQNDVYSLDNYFTGSRDNHVEGVTYIEGSTEHIFELINFTPDLIYHLGEYSRVEQSFEDIDKVLLFNKIGTLKVLEFCRKHRCKLVYAGSSTKFGDGGMGKDQSPYAWSKSSNTELIINYGNWYNLNYAIVYFYNVYGKREIHTGKYATLIALFTEKMKKGEPLTVVSPGTQQRNFTHIDDIVDGLLLVGQKGKGDGYGIGSPETYTVLEIAKLFGGEIQMLPERKGNRMTAEVVTQKTEELGWKAKKHIKEFIKNLAD
>NZ_CP022379|1301758:1309227|1307913_1309227_+|WP_095898327.1|DBSCAN-SWA
MSLETIREEIAKLVTQYAQEAYKPKPFEAGKTVIPPSGKVIGEQELQNMVAASLDAWLTTGRFNAAFEQKLAAFLGVKYCITVNSGSSANLVAFNTLTSPKLGDRAIKKGDEVIGVAAGFPTTVNPIIQFGAIPVFVDVDLHTHNVNADLIEQAITPKTKAIMLAHTLGNPFNLEKIKALCEKYNLWLVEDCCDALGATYNGQKVGTFGDIATLSFYPAHHITMGEGGAVFTNNAELKTIAESFRDWGRDCYCAPGKDNTCNCRFSQQHGDLPFGYDHKYVYSHIGYNLKISDMQAACGLAQLDRVEEFIEKRRKNFTYLKERLQTLTDFLYLPEATPNSDPSWFGFPITLKEKSGTTRVDLLRFLDQQRIGTRLLFAGNLIKQPYFQGVEYRIVGDLTNTDITMNQTFWVGIYPALGEEELDYIAEQLEEYFGVNF

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_095898321.1|1301758_1303078_+	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	1.3e-77	38.4
WP_095898322.1|1303088_1303937_+	NAD-dependent epimerase/dehydratase family protein	A0A0P0YMS6	Yellowstone_lake_phycodnavirus	2.4e-21	28.9
WP_095898323.1|1303940_1304951_+	NAD-dependent epimerase	M1HVB5	Paramecium_bursaria_Chlorella_virus	3.8e-05	21.7
WP_095898324.1|1304950_1305928_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	A0A1D8KP97	Synechococcus_phage	6.0e-08	40.3
WP_095898325.1|1305986_1306760_+	glucose-1-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_095898326.1|1306750_1307821_+	CDP-glucose 4,6-dehydratase	K7QJG5	Escherichia_phage	3.7e-11	23.8
WP_095898327.1|1307913_1309227_+	lipopolysaccharide biosynthesis protein RfbH	A0A0P0YLZ6	Yellowstone_lake_phycodnavirus	1.0e-50	33.3