CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP017369	Corynebacterium suranareeae strain N24	12 crisprs	DEDDh,csa3,cas3,WYL,PrimPol,DinG	3	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP017369_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_1

37053-37148

Orphan

Consensus_repeat	Method
AAGACCAAACACAGAGACCCAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_1

>merge|NZ_AP017369|1|37053-37148|CRISPRCasFinder
AAGACCAAACACAGAGACCCAGAAATCACATTTTCGACGTTTGTGGGTCTCCTAGTTTGGTGTATCGCTCTCAATACCAAACACAGAGACCCAGAA

>NZ_AP017369|1|1|37053-37148|CRISPRCasFinder
AAGACCAAACACAGAGACCCAGAA	ATCACATTTTCGACGTTTGTGGGTCTCCTAGTTTGGTGTATCGCTCTC
AATACCAAACACAGAGACCCAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096453271.1\|27659_28469_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235640
NZ_AP017369.1\|WP_096453307.1\|48804_49866_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378942
NZ_AP017369.1\|WP_096453293.1\|40030_41443_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP017369.1\|WP_096453277.1\|30409_31408_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197666
NZ_AP017369.1\|WP_167381975.1\|46022_46919_-\|DUF3662-and-FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|378850
NZ_AP017369.1\|WP_096453289.1\|37737_38010_-\|cell-division-protein-CrgA	unknown	unknown	gnl\|CDD\|178907
NZ_AP017369.1\|WP_096453301.1\|45544_46006_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_AP017369.1\|WP_096453297.1\|42867_44193_-\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NZ_AP017369.1\|WP_096453299.1\|44189_45545_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_AP017369.1\|WP_096453291.1\|38102_40034_-\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP017369.1\|WP_096453295.1\|41446_42871_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NZ_AP017369.1\|WP_096453281.1\|32876_33857_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182464
NZ_AP017369.1\|WP_096453275.1\|29182_29839_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_AP017369.1\|WP_096453279.1\|31887_32865_+\|Fe2+-enterobactin-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|236806
NZ_AP017369.1\|WP_167381974.1\|28572_29094_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_AP017369.1\|WP_096459499.1\|33913_34870_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_AP017369.1\|WP_167381969.1\|36716_36878_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096453305.1\|47792_48533_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096453283.1\|34870_35650_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_AP017369.1\|WP_096453285.1\|35646_36471_+\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|225250

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096453271.1\|27659_28469_-\|hypothetical-protein	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	0.00111947
NZ_AP017369.1\|WP_096453307.1\|48804_49866_+\|hypothetical-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	0.0037871
NZ_AP017369.1\|WP_096453293.1\|40030_41443_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.44558e-113
NZ_AP017369.1\|WP_096453277.1\|30409_31408_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	6.38569e-19
NZ_AP017369.1\|WP_167381975.1\|46022_46919_-\|DUF3662-and-FHA-domain-containing-protein	gnl\|CDD\|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	8.61502e-41
NZ_AP017369.1\|WP_096453289.1\|37737_38010_-\|cell-division-protein-CrgA	gnl\|CDD\|178907	PRK00159, PRK00159, putative septation inhibitor protein; Reviewed.	8.2798e-46
NZ_AP017369.1\|WP_096453301.1\|45544_46006_-\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	2.60141e-24
NZ_AP017369.1\|WP_096453297.1\|42867_44193_-\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	3.597e-85
NZ_AP017369.1\|WP_096453299.1\|44189_45545_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	7.35708e-74
NZ_AP017369.1\|WP_096453291.1\|38102_40034_-\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.81101e-121
NZ_AP017369.1\|WP_096453295.1\|41446_42871_-\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	2.80405e-91
NZ_AP017369.1\|WP_096453281.1\|32876_33857_+\|iron-ABC-transporter-permease	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	1.8877e-79
NZ_AP017369.1\|WP_096453275.1\|29182_29839_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	4.26007e-21
NZ_AP017369.1\|WP_096453279.1\|31887_32865_+\|Fe2+-enterobactin-ABC-transporter-substrate-binding-protein	gnl\|CDD\|236806	PRK10957, PRK10957, iron-enterobactin transporter periplasmic binding protein; Provisional.	4.93118e-118
NZ_AP017369.1\|WP_167381974.1\|28572_29094_+\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	1.02499e-64
NZ_AP017369.1\|WP_096459499.1\|33913_34870_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.20535e-113
NZ_AP017369.1\|WP_096453283.1\|34870_35650_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.94988e-127
NZ_AP017369.1\|WP_096453285.1\|35646_36471_+\|siderophore-interacting-protein	gnl\|CDD\|225250	COG2375, ViuB, Siderophore-interacting protein [Inorganic ion transport and metabolism].	4.29251e-69

>NZ_AP017369.1|WP_167381969.1|36716_36878_-|hypothetical-protein
MKSFQSLAQQAKQSWSDDAVMVYDAATASYSADINARVRLGLEPTETRTQQND
>NZ_AP017369.1|WP_096453285.1|35646_36471_+|siderophore-interacting-protein
MRNTDNGLSESAHDRDISEITATITALDRPSPSLLRFTALIPGSANNPVWGQPNVAIRLYLTEEFDNATRIYTVRTFDPSTESIVVDVVQHHHDSPMMRWSDTIKINDTVVLTGPRPHFIIPKGEQVALFLDDTAIPALAAIMDQWPTGLRGKGWVVTDDPAAFHELPIIDGLQLELLAPGENAQDQPLARQAYNLENPETYVVWAAGERDEMKSIRRHFRNQVGLEKDAVAVFGYWKYNTTNTQIDAARKENYMKMLSEGQQLENFDDLSLEI
>NZ_AP017369.1|WP_096453283.1|34870_35650_+|ABC-transporter-ATP-binding-protein
MLQAHDLTLGYGGRHIVEGLSLDIPEGGLSIIIGPNGCGKSTVLKALGRLLKPQSGQVTLHGRDISSMGTKQVAKHIGLLPQSPHAPDGVSVTELVSRGRYPHQHLLSQWSKDDEKIVERCLAEVAMHAHADHLVSELSGGQRQRAWIAMALAQETSILLLDEPTTFLDIAHQIAVLDLCSELHQRGQTLAIVLHDLNMAARYATHIIAMRDGTIIDQGKPDDILTEALLKEVFDLDALVLKDPNNGRPLIVPKDRRNQ
>NZ_AP017369.1|WP_096459499.1|33913_34870_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MVALMGFCVVVILIHFSLSAGSITALKAWSAAVGIGDPSDIRSVQSRRLPRVLTAVGVGAALGLSGAVFQSVSRNALGSPDIIGFTTGAATAAAINIIFFGGGVVFTGVAAIIGGLVTALFVYVMARHNSSTGGMRLVLVGIGTGAFLGAVRDFLMVRADITDATTVQLWSAGSLSGRGWNHALLVLGSCAVVIPLLSIIARRLRLMEMGDEAAGALGIAVEKTRLIAILLAVLLVGIATAAAGPIAFIALAAPQIAKALAREDGVLVAASISIGAALLVVADYLAQHVDIGLRTPVGLVTSLLGGVYLMWLLSRKEA
>NZ_AP017369.1|WP_096453281.1|32876_33857_+|iron-ABC-transporter-permease
MVIFGSLALMIVSIFVGLWFGSASVSPGEVFKAFVQFDPTNNDHLIIRHSRVPRILLGVIVGIALGLAGAIMQSLTRNPLADPGILGINAGASAAVVIAIAYFGMTDVSSYLWWAFIGAALAAVVVYMLGGVSKNGASPARLALAGAALAMAIGALTSMVLVSNESAFNQFRYWTVGSLQGRDLDVITAVVPFIVVGVVVSLLLIRSLNAIALGEDSARGLGANIPLIRVGSFLAVVLLAGAATAAAGPIAFIGLAAPHIVRLIVGPDNRKLIPGVLFLSPALLIMADSIGKTAAAPGELQTGIAAAVLGAPVFIALVRSKKVTAL
>NZ_AP017369.1|WP_096453279.1|31887_32865_+|Fe2+-enterobactin-ABC-transporter-substrate-binding-protein
MSRTLKLLAIGMIALLATGCSQSVSEEAESTTTTDGQWPRTITHEAGETTIPEQPLRIVSTSPSITGTLLAVDAPVVGTASALVTSLADDKGFFTQWADVADERGVEVVYSNLEIDLDAIDSFEPDLIIGAISGGDSVAAEYDQLSDIAPTVLLNYAEPSWQELTETVAEITGHEDDAQQILAEYDEFVSEQASLISLPEQPVTVLSYMGADGGWVLDADSQQGLLLDSIGFDYVGVAPEFASQSNNGVSQVSPENLPAALEQSQTLFLMPTGGPTPIEEFTGNALLANLPAVKNQRVFDLGDQSFRLDYYSARSTVEHVVSLFK
>NZ_AP017369.1|WP_096453277.1|30409_31408_-|helix-turn-helix-domain-containing-protein
MTTLPIAEIARRVGLSERTLQRRFLEETGLNVGTWRTRTRLSLAVAYLSDGHTAEWAAHHVGFSGASSLAKAFRTHMGISPSQIHKLQTAHNTVPPVLGLRTGEIPENETWTRINGSHIMVWAFQGSSVVHVADRKFTVNQGEGIILPAGVRLDLHTPAGGLILPLGYQVPRAQTLGAQHVDVIQFQCSTNKLLECTISTYTPFHPHHKNPDQCFSLPFSKISTDQPPLSNDDDTLIALATDLAASRQTNVSDIRGGIAEGFAHITGIAVQRWGLVRRMTLARIQLSRGLTPGVVARNLGYAHLSAFNRAFTATHGCTPAQYQVDCVRIPTP
>NZ_AP017369.1|WP_096453275.1|29182_29839_+|rhomboid-family-intramembrane-serine-protease
MNVERLYRQAPASTVISAVIIVVYALTAIQSRSLTNNLGASSIGDAWILYAPAMDHGFGPLRAIGGMFLHIGPGHMLLNLLLLWLFGREIERDFGSALFIAMYFVGGIGASAAVIWMDPFSPTAGASGAIYAMMSILVGLFILRGADIRAPLILIAINIAYTLSASGVSLWGHLGGLITGALITWPMIKAKTYKTQWLIVTIGLVLSIVAVFLGIARI
>NZ_AP017369.1|WP_167381974.1|28572_29094_+|peptidylprolyl-isomerase
MTSKTATAILHTNRGDISIDLFGNHAPETVANFVGLAQGTKEYKSANAQGGSEGPFYDGAVFHRVIDGFMIQGGDPTGTGRGGPGYMFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRSDRPTDAVVIESVEIV
>NZ_AP017369.1|WP_096453271.1|27659_28469_-|hypothetical-protein
MSTIGNLKLVVDGARKAYGTYADYRDRKVSETYDALSHAAGEYAPKAEQAVESARESAKEFYAESRDKAGNVTKAARARLEKALAEAEKQGSSALKDARKSGKKLNRKARRKADKAAKAARKAAGKKESHWVRNLSLAALATSGVVAVAYALLNKSKKEAPGTQPPRVEVQLKKAVEQEEPKMEPEKQPEEAAEPNLVFTTESSENAEASTPIDADLEAEIDAELNGEAAETADATDDVTDEVEAEAEAIQAEFDKKNAPQRDQSDKKK
>NZ_AP017369.1|WP_096453289.1|37737_38010_-|cell-division-protein-CrgA
MPKARITKNETAPVSSNPSANRTPVKINSAGTPMWYKVIMFAFMIIGLVWLIANYLAGPQIPFMADLDAWNYGIGFGLMIIGLLMTMGWR
>NZ_AP017369.1|WP_096453291.1|38102_40034_-|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTFVIADRYELGAVIGSGGMSEVFAATDTLIGREVAVKMLRIDLAKDPNFRERFRREAQNSGKLSHPSIVAVFDTGEVDRDGTSVPYIVMERVHGRNLREVVTEDGVFTPVDAASILIPVCEALQASHEAGIIHRDVKPANIMITNTGGVKVMDFGIARAVNDSTSAMTQTSAVIGTAQYLSPEQARGKPADARSDIYATGCVMYELVTGKPPFEGESPFAVAYQHVQEDPTPPSDFIANLTPTSALNVDAVVLTSMAKHPADRYQTAAEMAADLGRLSRNAVSHAARAHVETEEEPEPRLSTRTSTRIAPASGEAGASRSAGSSKRGSKGLIALATVLALGVVGVAGAFTYDYVTNSSSSATQAIPNVEGLPQQEAVTELEAEGFNVNIVEEPSADVSTGLVIRTNPSVGSEIRRGATVTLTVSTGREMINIPDVSGMTLEEAARTLEDAGLELNQNVREENSDDVEEGRVIDQNPEAGQEVVVGSSVSLTMSSGAESIRVPNLTGMNWSQAEQNLISMGFTPTASYVDSEQPEGEVLSVSGQSTEQPKGSTITVEVSNGMLIKAPDLARLNTQQAIDALRAAGWTAPDQSLIVGDPIRTAALVDQNKIGHQSPSPNDLFRKDAQVTVRLFEFDISALIQDQ
>NZ_AP017369.1|WP_096453293.1|40030_41443_-|serine/threonine-protein-kinase
MSQEDITGKDRLQELIGADYRLQWIIGHGGMSTVWLADDVVNDREVAIKVLRPEFSDNREFLSRFRNEAQAAENIDSEHVVATYDYREVPDPAGHTFCFIVMEFVRGESLADLLEREGSLPEDLALDVLEQAAHGLSVIHRMNMVHRDIKPGNMLITANGIVKITDFGIAKAAAAVPLTRTGMVVGTAQYVSPEQAQGKEVTAASDIYSLGVVGYEMMSGRRPFSGDSSVSVAIAHINQAPPQMPTSITAQTRELIGIALRKDPGRRFPDGNEMALAVSAVRLGKRPPQPRTSAMMAQAEAPSPSESTAMLGKVARPATITQQAAPKSGSGIGIGLFIAALLAVIIGAVIYAGTTGMLFNNTPEETTTPETITETYTPTVEETTSEWVPPTLPPMPTYSEPETSTHQTTTSEESTTEEPSTETSTTTSRTSTPFPTSTPRTSASVPDETTAPADDLIDAVNGLLDVGGAQ
>NZ_AP017369.1|WP_096453295.1|41446_42871_-|penicillin-binding-protein-2
MNRSIRITSIFSLILILVLIANLTWIQAFRDDELAQNPLNARGFLEAKSTPRGQISAGGQVLAESSQDDQGYYQRSYITNPSAYAPVVGYLSDIYGAAGLELGYNSVLNGSDPSLFTSQWLDVISGSPSHGANIELTLDTNAQQTAYEQLSQSGYEGAVVALRPSTGEVLAMASSPSYDPNQIVDPATAEQAWEEYTSSEGAPLLNHATQESLPPGSIFKIITTAAALENGYSADSTVTAEAAVTLPGTNTTLTNYGGQTCAGGGTTTLLTAFQLSCNTAFVETGIDVGVDALRAAAEDFGVGQTYDLGLSNVPGGLGEIPDDAALGQSSIGQRDVEMNVLQAAVMAGTVSNGGVRMEPYLVSKVTGQDLSELSTHKPKSVGGVEPEIAEQLKTLMEASERNTSGYAGIQIASKTGTAEHGDENTPPHTWYVAFNNDVAVAVLVKNGGGFGTGATGGQVAAPIGRAVLQAAGGF
>NZ_AP017369.1|WP_096453297.1|42867_44193_-|FtsW/RodA/SpoVE-family-cell-cycle-protein
MNTLERLKLRRKEMWLLILATLVVSIMFISLELAMGNELGAHILMLIGGYIGVFIVAHLAMAWVAPYADQIMLPVVAVLNGIGLVMIYRLDNATGYNTVNSQLMWTFVGVVLMVAVLLLLRDHKSLSRYSYILGVVGIVLLALPLVWPQPGGVEARIWIWLGPFSIQPGEFSKILLLLFFAQLLATKRALFTVAGYRFLGMDFPRLRDLAPILVVWALAILIMAGANDFGPALLLFTTVLAMVYLATGRGSWLLIGAVLVAVGAFAVYQVSAKIQERVQNFVDPVAHYDTTGYQLSQSLFGMSWGGITGTGIGQGYPNMIPVVHSDFILAAIGEELGLVGLAAIIVLFGVFVTRGMRTATLARDSYGKLVASGLSMTIMIQIFVVVAGISSLMPMTGLTTPFMSQGGSSLMANYILLAIILRISDSARRPLMSKPAAEVSA
>NZ_AP017369.1|WP_096453299.1|44189_45545_-|serine/threonine-protein-phosphatase
MLKLKYAVASDRGLVRGNNEDSAYAGPHLLALADGMGGHAAGEIASQTMINHLRALDVDPGDNDMLALVGMVADEANAAIADGIAEDPARDGMGTTLTAFMFNGRDLAMCHVGDSRGYVLRDDKLVQVTVDDTFVQSLVAEGKLDPEDVSTHPQRSLILKAYTGHPVVPTLEQFPALPGDRLLLCSDGLSDPVTHSTIEETLRIGTPQDAATKLVELALRSGGPDNVTVIVSDVVEVSEEEAAEEASAPLTAGALNGEQPEDPRPDTAAGRAAAITRRPQVIDPAPKISDAGTEDVPTIEEPPEKSSSKLAVLIVALVILIGVVAAGWWGYSRIDSTFYVAVNDEEAITVEQGVDYRIFGKDLHSEFQVACLNEAGTLSLKESCENGTSFKLDDLPASVRGNVAGLPSGSYDEVQAQMQRLAAQALPVCVNKEVTTGGDRNEPGVNCREVS
>NZ_AP017369.1|WP_096453301.1|45544_46006_-|FHA-domain-containing-protein
MDSLVLLGLRVALLVVLWFFVLMALRAMRADLKVTGQASTSNSVAAPQGLARAFNRSSPPRLLTVVEGPLAGSSIEVSEDMTMGRSPECTFVVGDDYASGMHARVFKRGSEWFVEDLDSRNGTFVGGTRIDQPEQIAVGTDIRIGRTTVRLVP
>NZ_AP017369.1|WP_167381975.1|46022_46919_-|DUF3662-and-FHA-domain-containing-protein
MATSSRIANAMNSLAKLDSSMQRGLDNALAFVFRGRVVPAELEELLKQEAEDNVVHTEYGYVEAPNVFKVSVSPNDFSNLVDRFPDQPPRFGDQMMRFCRNSGWTLVGPVVVLIEEDSSLHTGQLKSVSEKDPDPELSSGYLPLEGDGILPVAESESKNVSDSSPYTGTEFLPAQSAERPLVQGVSQSQVDAHRQGGLKPAGPTVTLLLQDGSSRTYVVQEGSNIIGRSNDADLRLPDTGVSRQHVEITWDGRDAILVDLKSTNGTTVNDTPVDNWLLADGDVITVGHSNIEVRIVSP
>NZ_AP017369.1|WP_096453305.1|47792_48533_+|hypothetical-protein
MTDWRTGQYPGNGSDSVEYLRHKFTNSLLSVCSLIVFEQDKTINAIEKNYGNESEEFKKAKQAYALLFDSNFGYRFLSKLRNVMHHDTMDVLSIDIHAGVNGPIRQGVADVRLARTPLINSRHCNRQLKAQLRELDQDPMYLEMMLQAISGLKVVTRYLRPLVEPALEDHCAILRSFELLYGGEAGQRMLGRGTIEIIEGVPRLPRYERVDAEILDFVHGNVQPIPVFDYETIAPFDSEIFASELT
>NZ_AP017369.1|WP_096453307.1|48804_49866_+|hypothetical-protein
MSARLYQGQLDSKRKQRVDAEKKTGEFRIKESTKRADAAKARLSASRSKNQSTIQSKLREADRRESEAETAGKEANRWQAKASGYAKEELNLEIKLARAKQMEADAVERKRKREQLARERREIAERTELQSRISHSELTIDRALRQLPAPKSEKLRVLILGASSSGDLRVGREQKRIRAAVESALHRDQIDLDVRPAATTDDLLDGITKFRPHIVHFSGHSNDELIVFERELDEPHEGAIISAHAFARALSATDDPPLLILLNSCNSATQIGDLVEQVAPFAIGMANVISDGDAINYAAQFYAAVANGQSINSAHMAGQARLELDGLDSADLPTLAFAPDVDPGLTVLVSPPA

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Crispr_ID: NZ_AP017369_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_2

348325-348431

Orphan

Consensus_repeat	Method
GGCGCGGAAGTCTGCCCTGTTTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_2

>merge|NZ_AP017369|2|348325-348431|CRISPRCasFinder
GGCGCGGAAGTCTGCCCTGTTTTGCGCGGGGCGGGTTGGGGTGGTGCGAAACAGGGCGAGTTTCGGCCGCGGACGGTCGCTTTGGCGCGGAAGTCTGCCCTGTTGTG

>NZ_AP017369|2|2|348325-348431|CRISPRCasFinder
GGCGCGGAAGTCTGCCCTGTTTTG	CGCGGGGCGGGTTGGGGTGGTGCGAAACAGGGCGAGTTTCGGCCGCGGACGGTCGCTTT
GGCGCGGAAGTCTGCCCTGTTGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096453758.1\|346214_346496_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|223706
NZ_AP017369.1\|WP_096453756.1\|345455_345983_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096453744.1\|338523_339159_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_AP017369.1\|WP_167381987.1\|343289_344465_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223594
NZ_AP017369.1\|WP_096453768.1\|351033_351495_-\|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein	unknown	unknown	gnl\|CDD\|238451
NZ_AP017369.1\|WP_096453776.1\|354001_354829_-\|molybdate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270256
NZ_AP017369.1\|WP_096453772.1\|351978_353163_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_AP017369.1\|WP_096453774.1\|353166_354021_-\|molybdenum-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226629
NZ_AP017369.1\|WP_096453760.1\|346492_347980_-\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NZ_AP017369.1\|WP_096453762.1\|348639_349533_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NZ_AP017369.1\|WP_096453746.1\|340109_340706_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NZ_AP017369.1\|WP_096459574.1\|339155_340088_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NZ_AP017369.1\|WP_096453766.1\|350585_351044_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NZ_AP017369.1\|WP_096453778.1\|354898_355156_+\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340560
NZ_AP017369.1\|WP_096453770.1\|351491_351962_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_AP017369.1\|WP_167381986.1\|342250_343147_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596
NZ_AP017369.1\|WP_096453780.1\|355164_356079_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226359
NZ_AP017369.1\|WP_167382156.1\|344472_345435_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176180
NZ_AP017369.1\|WP_096453748.1\|341433_342234_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224057
NZ_AP017369.1\|WP_096453764.1\|349524_350589_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|235526

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096453758.1\|346214_346496_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|223706	COG0633, Fdx, Ferredoxin [Energy production and conversion].	5.57516e-15
NZ_AP017369.1\|WP_096453766.1\|350585_351044_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	4.23597e-43
NZ_AP017369.1\|WP_096453744.1\|338523_339159_+\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	5.23323e-69
NZ_AP017369.1\|WP_167381987.1\|343289_344465_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	3.2098e-61
NZ_AP017369.1\|WP_096453768.1\|351033_351495_-\|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein	gnl\|CDD\|238451	cd00886, MogA_MoaB, MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.	6.9084e-53
NZ_AP017369.1\|WP_096453776.1\|354001_354829_-\|molybdate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270256	cd13538, PBP2_ModA_like_1, Substrate binding domain of putative molybdate-binding protein;the type 2 periplasmic binding protein fold. This subfamily contains domains found in ModA proteins of putative ABC-type transporter. Molybdate transport system is comprised of a periplasmic binding protein, an integral membrane protein, and an energizer protein. These three proteins are coded by modA, modB, and modC genes, respectively. ModA proteins serve as initial receptors in the ABC transport of molybdate mostly in eubacteria and archaea. After binding molybdate with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ModA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.33545e-79
NZ_AP017369.1\|WP_096453772.1\|351978_353163_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	3.11861e-117
NZ_AP017369.1\|WP_096453774.1\|353166_354021_-\|molybdenum-ABC-transporter-permease	gnl\|CDD\|226629	COG4149, ModC, ABC-type molybdate transport system, permease component [Inorganic ion transport and metabolism].	9.14653e-74
NZ_AP017369.1\|WP_096453748.1\|341433_342234_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224057	COG1134, TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	2.8854e-120
NZ_AP017369.1\|WP_096453760.1\|346492_347980_-\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	0
NZ_AP017369.1\|WP_096453762.1\|348639_349533_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	0.000472132
NZ_AP017369.1\|WP_096453746.1\|340109_340706_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.61695e-35
NZ_AP017369.1\|WP_096459574.1\|339155_340088_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.82634e-60
NZ_AP017369.1\|WP_096453770.1\|351491_351962_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	1.29442e-90
NZ_AP017369.1\|WP_167381986.1\|342250_343147_-\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.20147e-70
NZ_AP017369.1\|WP_096453780.1\|355164_356079_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	1.268e-99
NZ_AP017369.1\|WP_167382156.1\|344472_345435_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.244e-159
NZ_AP017369.1\|WP_096453764.1\|349524_350589_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|235526	PRK05597, PRK05597, molybdopterin biosynthesis protein MoeB; Validated.	0
NZ_AP017369.1\|WP_096453778.1\|354898_355156_+\|MoaD/ThiS-family-protein	gnl\|CDD\|340560	cd17040, Ubl_MoaD_like, ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins. Ubiquitin-like (Ubl) domain found in a group of small sulfide carrier proteins This family includes ThiS, MoaD, CysO, QbsE, and their homologs, which are structurally homologous to ubiquitin (Ub) and may function as the sulfide donor for the biosynthesis of thiamin, molybdopterin, cysteine, thioquinolobactin, and other sulfur-containing natural products. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of Ub and the epsilon-amino group of a substrate lysine. Like Ub, small sulfide carrier proteins in this family are adenylated at a diglycyl C-terminus by specific activating proteins. The adenylated C-terminus is subsequently converted to a thiocarboxylate, serving as the sulfide source. Those activating proteins are diverse and show little sequence similarity. This family also includes the small archaeal modifier protein (SAMP), including SAMP1, SAMP2 and SAMP3, which are Ub-like proteins that function as protein modifiers and are required for the production of sulfur-containing biomolecules in the archaeon Haloferax volcanii. SAMP1 and SAMP2 are involved in sulfur transfer during molybdenum cofactor biosynthesis and tRNA thiolation much like MoaD and Urm1, respectively. They can form covalent conjugates with their protein targets through an isopeptide linkage via their C-terminal diglycine motif in a streamlined archaeal E1-dependent pathway. SAMP2 also forms homo-conjugates through the intermolecular isopeptide bond between the C-terminal Gly and the Lys58 side chain, a feature that likely resembles polyubiquitination. SAMP3 conjugates are dependent on the Ub-activating E1 enzyme homolog of archaea (UbaA) for synthesis and are cleaved by the JAMM/MPN+ domain metalloprotease HvJAMM1.	1.57824e-12

>NZ_AP017369.1|WP_096453760.1|346492_347980_-|sodium:alanine-symporter-family-protein
MDLLETFFTDVINDNLWMILPFLLVAAGLYFGGRTLLVQIRMIPEMFKAVVEKPAKEGEFADKQDISAFKAFTISAASRVGTANVAGVALAITLGGPGAVFWMWIIALVGGATSFIESTLAQLWKVKDGDSYRGGPAYYMTLGLNARWLAVIFGVAITLTFGFVYNALQSNAVVEAITVSLGTPSTTAKALVGLGMAGLSALVIFGGVQRIANVTQWMVPFMAGAYIIVGVLVIVINIQQVPTMINDIIAGAFGFRPVATASVWGAFWLAFMNGMRRGLFSNEAGEGSVPNAAATATVSHPVKQGLVQTLGVYFDTLLVCSITAFIILLSGVDYATGDIQSSSLTQSALANVVGAWGTHFITAVMFFLAFSSVLGNYYLAQANIQYFTDSKTVLTIFRVFVLLSVFSGAVASVPLIWALGDTFAGIMVLINLSAIIPLGGVAVKLLKNYTKQKKAGLDPVFHRDMLPEVRNIACWNGKDAATANYQEAMDVIKKN
>NZ_AP017369.1|WP_096453758.1|346214_346496_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MALHTHKIDGETYAFSWSPTQTLLDALLQADLPARYSCMEGHCGSCQCTLTGGPSHMLNNEVLSTYEIVTEHQVLACQTIRDADGPYHCSFDD
>NZ_AP017369.1|WP_096453756.1|345455_345983_-|hypothetical-protein
MDVFKVAFIAAIMIGVPVLVVFLFVFAVHRLAKEMPRSERRPGAVLGLLLGFAAGVIVWLVWLSWGGYYEDDFGQMQGPYRPWQVVACGVTMVAVTVLLGLWTRWTASGPFYAALGGTSGFSFAWAMDALPQDETGLSAFGLLMVIVGVGMGLNVVAAITSICATMWHNRLPSNT
>NZ_AP017369.1|WP_167382156.1|344472_345435_-|zinc-binding-dehydrogenase
MKAIVQTEEKVTASLELQEIPVPTLKPGEVLVEVKAAGVNRADLLQTQGNYPVPPGASEILGLECAGVIVDAGDTGQTVGREVACLLTGGGYAEYVAVPEGQLMPIPAGYSFVEAASIVEVACTVWSNIGMLANLGSRQNPTFLIHGGAGGIGTFAIQMGKALGATVAVTAGSAEKLATCKELGADILINYKEEDFAEVLKNKADVILDIIGAKYLSQNVKAMAKDAHMVVIGMQGGVKGELNLGHLLAKRGTISATALRGRDEADKARIVSSTIENIWPLLESKKISHHIDHTLPLAEAADALQKIQDGTVTGKLVLTV
>NZ_AP017369.1|WP_167381987.1|343289_344465_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MGFDVARVRGLYTSLGDGWTYLNSHQIPQVPERVASGVAAAFRTHAQISEATLQPIAVDQLEAAREAVAGMVGADPACVVLGPTRQFLAHAVARGLGGFVRRKAGVVLSRADAGWLTAPFRALDGSFSWAEPDLGTGQLPDWQYKELVDGSTRLVVLSAAHPLLGTVAPVGKIVDTVRARSRAWVLIDATTYATYRPLDLDEWQADIVMLDLGEMGGPQISALIFRDTSMFPRMDQTMPLELPASSLPHGLLGGVPNLVRHLGNLDEEAESVAEAMGSMADFHKGLFEHLVESLEGLHAVHIVGISGDAAGQDAAFLDRVPRLTFTVEGVPAEMVYRRLVDNRLVTTVSPADPLLDAMGVTEAGGSITIGLSPFSTHYEVDQLTRVLASLA
>NZ_AP017369.1|WP_167381986.1|342250_343147_-|ABC-transporter-permease
MQEQSKQKDLQADIARITAVTSDTAPDSQSMTIKAAWNDIVRGFKQHELWLQLGWQDIKQRYRRSVLGPLWITIATGVMALALGLLYSVLFKIPLAEFLPHVTVGLILWNFISGCIKEGADIFIDNEGLIKQLPSALSVHVYRLVWKQALFLAHNLVIWLLLMLIFPRPLGWDVLLIIPGMFLLVINGVWVVMFFGIVATRYRDVSPLLEAGTQLLFYVTPIVWMTSTLQDHSAEMGSRARLAELNPLYHYLEIVRAPMIGADLPAYHWWVVIAFTFVGLGLALLAMKQWRFRVSYWV
>NZ_AP017369.1|WP_096453748.1|341433_342234_-|ABC-transporter-ATP-binding-protein
MVSIDTYNACVDFPIFDAKSRSMKKAFLGAAGGAIGRNQDNVVVVEALKDINLHLREGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGSADIRGRVAPVFDLGVGMDPEISGYENIIIRGLFLGQTRKQMKAKMEEIADFTELGEYLSMPLRTYSTGMRIRLALGVVTSIEPEILLLDEGIGAVDAAFMAKARNRLQALVERSGILVFASHSNDFLAQLCNTALWVDHGQIRDAGLVPDIVEAYEGKGAGDHVRRLLTRMEEEETEA
>NZ_AP017369.1|WP_096453746.1|340109_340706_-|VOC-family-protein
MGTHIDHIVIAAPNLEDLVSRFEKLTGVKAVAGGRHDTGTANALVPLAGTKSYLELIGPDPEATAVTRDNFAIATTTSTEPRVAAWCVRPDDLEALAKQRGTQSHPMSRHTPEGTTLSWRLILPEPGVDFAPVPFAIDWLDSPHPSKVTELQVSIHSFTVYGPTKPDELPEPAKFQQGEPYLELVLESPKGRVNLSDL
>NZ_AP017369.1|WP_096459574.1|339155_340088_-|glycosyltransferase-family-2-protein
MAKTGTHLQHGIDVAAVIVTHNRVELLRHSLEVVVSQSYPVKHIVVVDNGADPDVEKLVLEVAGDRAVYTPSRTNLGGGGGFAFGFLTALALGADAVWCADDDGRPEGPEVLKTLIDAASRHNLEEVSPVVCNADDPERLAFPLRRGLEWRRMRSELIDPAKPEDDLLPGIASLFNGALISAYAMERIGVPDYRLFIRGDEVEYHRRLVRSGLPFGTCLTTAYLHPDGSDEFKPILGGRMHTQYPDNDFKRFFTYRNRGYLMSQPGMRKLLPQEYARFAWFFLVQKRDVKGFREWLRLHKLGRDEKFNRP
>NZ_AP017369.1|WP_096453744.1|338523_339159_+|MOSC-domain-containing-protein
MSGLVLSTNIAQIQQDPGGDDRISGINKLPVDTGIDVFIPGPNYGDGSGVVGDVIGDTLHHGGAHKAVYAFSREELDFWNPTYRNGYFGENLTTSGIVLEDLLINQQVRIGTTVLEVSIPRRPCRTFAQWLEIKGWLKTFTQRGLPGSYFRVIEEGHINPGDRIDILDAPDHDITMSMAFRAKMGNKDLARRVVAAHCLPSRYHEELLKLI
>NZ_AP017369.1|WP_096453762.1|348639_349533_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MRTAKELIRMKYSRRKINSLVKEGKLYRVLRGVYSMDPPSGEVVWSAIRLVRPGALLDGKSAVEVYQGVPLSLPLRVRVSTSNVLRGSANVVARRSQRITGVVHRGFRVVSLVDAIATCLEEKSSDLGDLRRLVEQRYQSGSGVNQMKHDLKALKTRRKKQLREFLEECIYGTDSGLEKKLVYELRDAGFKTRQNVMVEGYRWDIQVVGVALIDVDSRKYHQANGRNFIIDRWKSNEALVQGHVPLRFTDDCVNYAPGEIIKLVKQIAEFKRKHPRKRVKTQGVGPVFKWHNALVLP
>NZ_AP017369.1|WP_096453764.1|349524_350589_-|molybdopterin-biosynthesis-protein-MoeB
MKNLDIARYRRQIMLGEIGQQKQQSLFDATVSVVGAGGLGSPALLYLAGAGVGHIHIIDDDLVDLSNLHRQVIHTTAGVGTPKAESARDAMLALNPDIKVTVSVTRLTWENALSELSGSDVILDGSDNFDTRHLASWAAAKLGIPHVWASILGFDAQLSVFHAGHGPIYEDLFPTPPPPGSVPSCSQAGVLGPVVGVLGSAMAMEALKIITGVGTPLIGKLGYYSSLDGTWEYIPVVGSPEVLERVLGSSGVSPASSEELDVPRVSSLVDGVELIDVREPSEFSAYSIPGAHNVPLSAIREGTVPDAVSAGKEVIVYCAAGVRSAQAIAILESAGYTNMSSLDGGIEGWLDSLR
>NZ_AP017369.1|WP_096453766.1|350585_351044_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MNTDPAYVAAQTGKLIDAFITSDPLEPLLSDAKTAVLTDAMGALVTFEGIVRDHDGGARVSSLDYTAHPTADQVIKDVAAAVVAKHPRTRLWTAHRTGALKIGDAAFLVLAASAHRGDAFAACSELADIVKAQVPIWKEQTRLDGSTDWVGL
>NZ_AP017369.1|WP_096453768.1|351033_351495_-|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein
MTALVIVASTRAAAGVYEDRSGPILVNWLRSKGFDTPDAVIVADADLPAYLDTLEFPQVVLISGGTGLTPDDITVDTLLPRLDKEIPGIAHAFWAHSMNAVPTAVLSRTVAGTIGRSFIMALPGSTGAARDATAVLDPLINHITQTLQGHHEH
>NZ_AP017369.1|WP_096453770.1|351491_351962_-|cyclic-pyranopterin-monophosphate-synthase-MoaC
MSELTHVRADGSAHMVDVTGKNETSRTAVAEGFVRMRGDVVKQLFSAGLPKGDALPVARIAGIMGAKKTPDIIPLCHPLPLGKITVDFFELKDGVRIEASVKTRGVTGVEMEALTAVSTAALTVYDMIKAVDKMAVIDGIRVLSKSGGKSGDWSVQ
>NZ_AP017369.1|WP_096453772.1|351978_353163_-|molybdopterin-molybdotransferase-MoeA
MSRSPEEHLAEIKALLPTPEPELVNLEQAHGRRTFSAITAAWDSPRFDNSQMDGFALAPSHLSGGTFSVGPTIPAGHDPDTLYPRGLGKDIAPIMTGARLPKNTAAVIAVEKTKPGHFDAQQVEIPATPQKQFMRLQGSDIAAGEEIIPAGTVLNSVHLGVLASQSKKSVEVYKKPRVLIVTGGSEISEKLGAATIPDANGPLLRALCRRNNIDVITGLKTNDDPQRLRFDLEQAIDQYQPDAIITSGGISHGKFEVFRQILENTPEAWFGHVDQQPGGPQGISVFQDVPVISLPGNPISTLVSFTLFVAPALNHQPLCSSHAHITETVHGLKDNREQFLRGILSHQSGKLIVTPLLGTSSHLLVQAATANCLIRIPARTTVEENSLVQIYPFD
>NZ_AP017369.1|WP_096453774.1|353166_354021_-|molybdenum-ABC-transporter-permease
MALAQTKDRHTQRARRAENHILPGWLLIPATFAMLLIIGPIFALLLQIPWARSWELLTSPESLQTARLSIATALFSTVVCALVGFPLALALHLYERSFPKMTSVLTVLVYAPLVLSPVVSGLALTFLWGRRGILGSWLDQIGLPIAFTTTAVVFTQVFVALPFFISTVTTAVRGIPKQFEEIAATEGATKWEIMHKMIIPLAMPGIFTGMILGFARALGEYGATLTFAGNIAGVTRTIPLHIELGLSSNDMDKALGAVIMLLAVYVLIIGAIGALRMYSKVRKV
>NZ_AP017369.1|WP_096453776.1|354001_354829_-|molybdate-ABC-transporter-substrate-binding-protein
MNQGIRRAFYSFATISAGISLAACSSSDTASNSTSSTAEAPGSTSSSDATGVSGTASVFAAASLTNVAEDLAAAFNEENPDAQLEFNFAGSSALVRQISEGAPSDLFISADIANMDDALALPEFSGATSQVIATNKLVLVTADGNPGEISELSDVSDSLVAICAPEVPCGTITHEALDYANIELSTSSEEANVADVATKISTGAVDAGFVYQTDAQSLAKTQDNTVIELEGIDANEYPMALTTSGEDNEVAKAFAEFLTSDRAKEILASYGFGTN
>NZ_AP017369.1|WP_096453778.1|354898_355156_+|MoaD/ThiS-family-protein
MDIHYFAAARAARGVAQETVASSDKTLHDLLKDLGEKHTETTAAGMTLAQVFDRCTFLIDGRSADSSASLSGASRVDVLPPFAGG
>NZ_AP017369.1|WP_096453780.1|355164_356079_-|ABC-transporter-ATP-binding-protein
MADLHIDHVSRFFGDAAALNDVCLTVPSGSITAIIGPSGSGKTTLLRLLAGLDSPDEGTVRIGNKVARLGDTALCFQDSPLYPHLNVWDNVAFPLKLKATNTADDVLKKRVGEVLEMLEIDHLAQRKITELSGGQKQRVGIARALVRDVEVYLFDEPMAHLDQALARDIVIDLRKIQQSLGLTFVYVTHSKAEAFALADQIVVLVDGQVAQVGEAEELVEKPKTLTIAEFLSPTELNVRQRGDAVEAWRPEDTQLTRGGSAIVESVTYLGREWLVRTTEGQAVSEEKFEVGEAVTLTQKKVFSF

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Crispr_ID: NZ_AP017369_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_3

395525-395619

Orphan

Consensus_repeat	Method
GTTTTTGGGTCTCCTGGTTTGGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_AP017369_3

>merge|NZ_AP017369|3|395525-395619|CRISPRCasFinder
GTTTTTGGGTCTCCTGGTTTGGTGTATCGCGCTGAATACCAAACGTGGAGACCCAACTTTCGGATTTTTGAGGATTTTGGGTCTCCTGGTTTGGT

>NZ_AP017369|3|3|395525-395619|CRISPRCasFinder
GTTTTTGGGTCTCCTGGTTTGGT	GTATCGCGCTGAATACCAAACGTGGAGACCCAACTTTCGGATTTTTGAG
GATTTTGGGTCTCCTGGTTTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096453845.1\|403228_403810_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237130
NZ_AP017369.1\|WP_096453825.1\|387715_390043_+\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090
NZ_AP017369.1\|WP_167381990.1\|387064_387697_+\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_AP017369.1\|WP_096453833.1\|392919_394191_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_AP017369.1\|WP_096453835.1\|394220_395351_-\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235529
NZ_AP017369.1\|WP_096453849.1\|405644_405938_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_167381992.1\|405989_406445_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_AP017369.1\|WP_096453819.1\|382855_383737_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	unknown	unknown	gnl\|CDD\|235573
NZ_AP017369.1\|WP_096453831.1\|392167_392920_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_AP017369.1\|WP_096453827.1\|390168_390480_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_AP017369.1\|WP_096453853.1\|406519_407275_+\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NZ_AP017369.1\|WP_096453847.1\|404014_405565_+\|catalase	unknown	unknown	gnl\|CDD\|163712
NZ_AP017369.1\|WP_167381991.1\|395849_397700_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_AP017369.1\|WP_096453837.1\|397958_398828_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|283340
NZ_AP017369.1\|WP_096453843.1\|401463_402918_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379904
NZ_AP017369.1\|WP_096453839.1\|399087_400353_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_AP017369.1\|WP_096453823.1\|385781_387062_+\|aminotransferase	unknown	unknown	gnl\|CDD\|372371
NZ_AP017369.1\|WP_096453821.1\|383730_384711_-\|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl\|CDD\|239540
NZ_AP017369.1\|WP_096453841.1\|400376_401411_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_AP017369.1\|WP_096453829.1\|390582_391239_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096453845.1\|403228_403810_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|237130	PRK12535, PRK12535, RNA polymerase sigma factor; Provisional.	6.09591e-110
NZ_AP017369.1\|WP_096453825.1\|387715_390043_+\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_AP017369.1\|WP_167381990.1\|387064_387697_+\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	4.92159e-05
NZ_AP017369.1\|WP_096453833.1\|392919_394191_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	2.21299e-78
NZ_AP017369.1\|WP_096453835.1\|394220_395351_-\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|235529	PRK05601, PRK05601, DNA polymerase III subunit epsilon; Validated.	0
NZ_AP017369.1\|WP_167381992.1\|405989_406445_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	6.84947e-41
NZ_AP017369.1\|WP_096453819.1\|382855_383737_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	gnl\|CDD\|235573	PRK05710, PRK05710, tRNA glutamyl-Q(34) synthetase GluQRS.	2.54089e-124
NZ_AP017369.1\|WP_096453831.1\|392167_392920_-\|glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.05286e-104
NZ_AP017369.1\|WP_096453827.1\|390168_390480_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	5.59989e-37
NZ_AP017369.1\|WP_096453853.1\|406519_407275_+\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	1.2831e-53
NZ_AP017369.1\|WP_096453847.1\|404014_405565_+\|catalase	gnl\|CDD\|163712	cd08156, catalase_clade_3, Clade 3 of the heme-binding enzyme catalase. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 3 catalases are the most abundant subfamily and are found in all three kingdoms of life; they have a relatively small subunit size of 43 to 75 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. Clade 3 catalases also bind NADPH as a second redox-active cofactor. They form tetramers, and in eukaryotic cells, catalases are located in peroxisomes.	0
NZ_AP017369.1\|WP_167381991.1\|395849_397700_-\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_AP017369.1\|WP_096453837.1\|397958_398828_-\|DMT-family-transporter	gnl\|CDD\|283340	pfam05653, Mg_trans_NIPA, Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.	0.00259684
NZ_AP017369.1\|WP_096453843.1\|401463_402918_+\|hypothetical-protein	gnl\|CDD\|379904	pfam16933, PelG, Putative exopolysaccharide Exporter (EPS-E). PelG is a family of putative exopolysaccharide transporters like PelG. Most members carry twelve transmembrane regions. The family also contains fusion proteins with glycosyl transferase group 1, which are putative flippase transporters.	0.0066035
NZ_AP017369.1\|WP_096453839.1\|399087_400353_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_AP017369.1\|WP_096453823.1\|385781_387062_+\|aminotransferase	gnl\|CDD\|372371	pfam12897, Aminotran_MocR, Alanine-glyoxylate amino-transferase. These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration.	1.8069e-180
NZ_AP017369.1\|WP_096453821.1\|383730_384711_-\|intradiol-ring-cleavage-dioxygenase	gnl\|CDD\|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	9.04264e-69
NZ_AP017369.1\|WP_096453841.1\|400376_401411_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_AP017369.1\|WP_096453829.1\|390582_391239_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	4.40902e-108

>NZ_AP017369.1|WP_096453835.1|394220_395351_-|DNA-polymerase-III-subunit-epsilon
MPRNAVKTHQTTRVIKMSTTQESQDHAAKIEAERQQAIEAAPYVSVTIQSSGIHPSTSRMITIDLVTLSPRLEPVETFHAVLDSKTDPGPFHLHGVTEEEFAGAKRFGQILKSLDRLIDGRTLLIHNAARSWGFIVSEAKRAMNDAARANRNNNRGNRRGGRGRRRQRVGHIPKPLVIVDTLASARRQAIVLDDVRTRGVAATLGIEAPAAQASVARAQVPHRELCREETLLVARLYGALKETGPLAEIDPQSLRADKFGLQRSIIRVQAQEATPTLVNPGPYEPGKTLIAGMEVVVAPEIEMDPDIIIQACVDADLSYSEKLTRQTSVVVCNQTRDIDGKAMHAQRKGIPLLSDVAFLAAVKRVKEGKKVDVEKR
>NZ_AP017369.1|WP_096453833.1|392919_394191_-|Mur-ligase-family-protein
MKLSLPAPLRRLRSAAAIVSAKVATSASKATGRGSGGMIGGLVASKVDPDIMSNLINNRPTVLVTGTNGKSTTTRMLAAAMRSTYTVATNEGGDNMDAGIISALLAGRNASHVVLEVDELHVPAAIERLKPDALVLLNLSRDQLDRVGEINKIERVLRDAVRSRPEMTVIANCDDVLVTSVAFDAENVIWVGAGTGWQGESVTCPRTESRILHDGRHWSAQKTLLDGRTFARPTPSWEVDGDTIHSPSGDLALDLNLPGQANRGNAAQAIAAATVFNVPVSSALPAVNSVNNVAGRYSTINIGDHKVHLLLAKNPAGWQEALSMVDRTADGLVIAVNGQVADGEDLSWLWDVRFEDFEHLSVKASGERGTDLAVRLTYAEIDHELISNPVDAIAACPSGRIEVLANYTAFRDLKKALEKGTEN
>NZ_AP017369.1|WP_096453831.1|392167_392920_-|glutamine-amidotransferase
MTTLNIGLVLPDVLGTYGDDGNALVLRQRARMRGISAEIERITLDDAVPSNLDIYCLGGGEDTAQILATEHLTKHNGLQTAAAAGRPIFAVCAGLQVLGDSFRAAGRIVDGLGLLDATTVSLQKRAIGEVETTPTRAGFTSELTERLTGFENHMGATLLGPDAEPLGRVVRGEGNTDIWAASENSDDERQQFAEGAVQGSLIATYMHGPALARNPQLADLLLAKAMGMALKELAPLDIDVIDRLRAERLA
>NZ_AP017369.1|WP_096453829.1|390582_391239_+|recombination-protein-RecR
MFEGPLQDLIDELSRLPGVGPKSAQRIAFHLLNVDPMDITRLQEALGSVRDGVQFCRICCNISREEVCRICSDSGRDGGTICVVEEPKDIQVIERTGEFSGRYHVLGGALDPLANIGPRELNISTLLQRIGGVLPDRELADSTPENKLFDATPNVHEVILATDPNTEGEATASYLARLLKDFPNLVVSRLASGMPLGGDLEFVDELTLSRALSGRLQI
>NZ_AP017369.1|WP_096453827.1|390168_390480_+|YbaB/EbfC-family-nucleoid-associated-protein
MSQPDMSQILAQAQQMQAQLQAAQQEILATTVVGNAGNGLVTVTMAGNGEVSAVTVDPKVVDPDDVETLQDLLLGAFKDAHTKVANVAEEKMGPLSQGMGGLF
>NZ_AP017369.1|WP_096453825.1|387715_390043_+|DNA-polymerase-III-subunit-gamma-and-tau
MALYSKYRPASFGELVGQSQVTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALAPGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYRVFIIDEAHMISNQGFNALLKIVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPGDMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLLGVTSFTLIDDSIHALAAKDNASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEAINLGLVDAPTDRAEALLQQSTLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARLLLAGNTVVVPQQSEAAPAAAGGLTGAAAARAKARGYGQKKPAPEPAPEPAPEPAPEPVVETPPTPAPEPAPTPAPTPEPVAEVREESVEKQPESGDVLETIRNRWSQLRSAVGKQSVRTEIMLTEARVLGLRGDTLVLGHSTGALAARLNAADHNGILVKVLAEETGQQLKVECIVGTNPTDAGFTAQPPVQKNTWNPNHTSKPASTAPAAPASPAPAQQQKPESAPVEPEEPESPTESARGWGQPVKIGGPAPEPVAPVAPVAPAAPVVPPTPTEKPSWKERAQQAAANAAQQRQARQGSSEPFERGVPLPPEPDLPPDPYGYAPDEGIPENQGYQQPPEPSSVQSEPAPAPVVESAPVQPVAQPVVQQPEPEPLSEEEQLIREADEEPGQMDRRDAKTIAMELLAQELGAKPL
>NZ_AP017369.1|WP_167381990.1|387064_387697_+|suppressor-of-fused-domain-protein
MNTAETAHWINRLLPGTPEFHQVGAFKVAGYTLEDESIACSVDFGRVNTGLVTEGGAETVDVRSEILCLARAEVSVPGRAVGAAATMLLDASLSFKSAPDSSVTPMHAQPGQILPGVGIMANLPQQGYSVVHGILADPRIWGPEIPYVREEAGQVNVEAPDEAGDLARLTLPLQLILLTEEEFAYAMSNGSDVLFQHMAEQNVDLLDLKR
>NZ_AP017369.1|WP_096453823.1|385781_387062_+|aminotransferase
MSSVSLQDFDAERIGLFHEDIKRKFDELKSKNLKLDLTRGKPSSEQLDFADELLALPGKDDFKAADGTDVRNYGGLDGIVDIRQIWADLLGVPVDQVLAGDASSLNIMFDVISWSYIFGNNDSVQPWLKEETVKWICPVPGYDRHFSITERFGFEMISVPMNEDGPDMDAVEELVKDPQVKGMWVVPVFSNPTGFTVTEDVAKRLSAMETAAPDFRVVWDNAYAVHTLTEEFPEVIDIVGLGEAAGNPNRFWAFTSTSKITFAGAGVSFFLTSAENRKWYTGHAGIRGIGPNKVNQLAHARYFGDAEGVRAVMRKHAASLAPKFNKVLEILDTRLSEFGVAQWTVPAGGYFISLDVVPGTASRVAELAKEAGIALTGAGSSFPLRQDPENKNLRLAPSLPPVEELEVAMDGVATCVLLAAAEHYAN
>NZ_AP017369.1|WP_096453821.1|383730_384711_-|intradiol-ring-cleavage-dioxygenase
MAEQLRQFEGRVLPNQSEDLEDQGLGFDLGTVFSRRKVLGFIGVGGAGVALAACAPSGSSSASSTSSATSATSAAAETLTEMNSETAGPYPGDGSNGPDVLEISGVERQDITKSIDSDTVAEGVPLTLTMTLLDMSNNNQPMEGAAVYVWHCDAPGRYSMYDSELEDETYLRGVQIADKYGQVTFDTIFPGCYAGRWVHIHFEVFPDRDSITDSTNNILTSQIALDEASAASVYALDVYGNSLTNLNDISLDTDNVFSDGWDQQMANLTGDATSGFIASIDVPIDPTTEQNQSMNMPSGGQGGPGGQGGPGGMTPPDGMAPPQNAQ
>NZ_AP017369.1|WP_096453819.1|382855_383737_+|tRNA-glutamyl-Q(34)-synthetase-GluQRS
MAGRYAPSPSGDLHFGNLRTALLAWLFARSEGKKFLMRVEDIDEQRSSRESAESQLADLSALGLEWDGEVLYQSTRYDAYRAALEKLDTYECYCSRRDIQEASRAPHVAPGVYPGTCRDFGEEERVEKRASLAAQNRHPAIRLRAQVSSFDFYDRLRGPQTGPVDDFILLRGGQEPGWAYNLAVVVDDAFQGVDQVVRGDDLLDSAARQAYLGSLLGVAAPEYIHVPLVLNAHGQRLAKRDGAVTLKEMLIDAPLHTIFSRLASSLGYEGVNSAPQLLEIFDPTTLSREPFIY
>NZ_AP017369.1|WP_167381991.1|395849_397700_-|2-isopropylmalate-synthase
MSPNDAFISAPAKIETPVGPRNEGQPAWNKQRGSSMPVKRYMPFEVEVEDISLPDRTWPDKKITVAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKDMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATDAAELIKTIAQDYPDTNWRWQYSPESYTGTEVAYAKEVVDAVVDVMDPTPENPIIINLPSTVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYGGDLVFTAFSGSHQDAVNKGLDAMAAKVQPGANSTDVSWEQLRDTEWEVPYLPIDPKDVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSAVVQNVTDAEGGEVNSKAMWDIFATEYLDRTAPVEQIALRVENAQTENEDASITAELIHNGQDITVDGHGNGPLAAYANALEKLNIDVEIQEYSQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVNRALDVNHETVLAGGV
>NZ_AP017369.1|WP_096453837.1|397958_398828_-|DMT-family-transporter
MQSNLLAVLFALASALTIAWGTVVRHRIALRTPKDGSLRSSPLLNALMTPMWWAGMSTAMLAYFLQTVALGFGTLLVVQPVLVLSLMFTLPLSARFNGYRLRKTEISWATLLTIAVGIMIVLGRPLPGNPHPPLDRWIPALLTGVAVMGGMWLVAQYILKKDRALILGLITGALFGYVAVMSKAAVDIFVHQGISGLIFNWEGYGLILTALLGTIVQQYSFNAGELQKSLPAMTIAEPIVAFSLGYLVLGEKFQVVDWEWIAMGIALLVMIISTIALSRTRTMPATAKK
>NZ_AP017369.1|WP_096453839.1|399087_400353_+|aspartate-kinase
MALVVQKYGGSSLESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLDLAAAVNPVPPAREMDMLLTAGERISNALVAMAIESLGAEAQSFTGSQAGVLTTERHGNARIVDVTPGRVREALDEGKICIVAGFQGVNKETRDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELAAVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPVEEAVLTGVATDKSEAKVTVLGISDKPGEAAKVFRALADAEINIDMVLQNVSSVEDGTTDITFTCPRSDGRHAMEILKKLQVQGNWSNVLYDDQVGKVSLVGAGMKSHPGVTAEFMEALRDVNVNIELISTSEIRISVLIREDDLDAAARALHEKFQLGGEEEAVVYAGTGR
>NZ_AP017369.1|WP_096453841.1|400376_401411_+|aspartate-semialdehyde-dehydrogenase
MTTIAVVGATGQVGQVMRNLLEERDFPADAVRFFASPRSAGRTIEFRGAEIEVEDVTQATEESLKGIDVALFSAGGTASKQYAPLFAAAGATVVDNSSAWRKDDEVPLIVSEVNPSEKDSLAKGIIANPNCTTMAAMPVLKPLHDVAGLVKLHVSSYQAVSGSGLAGVETLAKQVSAVGDHNVEFVHDGQAADTGDFGPYVSPIAYNVLPFAGNLVDDGTFETDEEQKLRNESRKILGLPDLKVSGTCVRVPVFTGHTLTIHAEFEQPITVEQAQEILGAASGVKLVDVPTPLAAAGIDESLVGRIRQDSTVDDNRGLVLVVSGDNLRKGAALNTIQIAELLVK
>NZ_AP017369.1|WP_096453843.1|401463_402918_+|hypothetical-protein
MCEGRRGGGELVKWNFPEFFSFSSRENTADSTSDKEHENATELAAEALADVIFQWKNWVYRRVDSVHPSEGARGRLRHSMDCEAPPDPRLAYNEVERRYNDINDVKGQLTVPLAFIEKGPMRHLDVWRNDGTSIPILGSEETSELMVAVLMLFLKKNGIERTSELEDAMRALVASREKGNLAKATNLIESGMWEGKTLWDSNDPAVRFDVGTKDLLLNLSTDFLLMGLLPTETSGVRQVLKFSYHWVVELPDRGLLRSLWGSVCVAFRAAPMEIELPTHMPTEAKSYHLEFHTPPELDIQELSLPVEPINQGHQVGYPTDSNRTPIAHVHSNFSEIMTANAKVKLEVPKRGIWVTALLSNTLTAGIFILALLLPNATDALRSVGGNAAALMLAAPAVFVSFLIFPKEHIFVSSMLNPLRIVVGVCALLLFTMAGSLVGGLERPLLILLWSFGAGFSVLVVSALALGPLLGKLFERLHLRPSTKN
>NZ_AP017369.1|WP_096453845.1|403228_403810_-|RNA-polymerase-sigma-factor
MKSKERNDAHVTELALAAGRGDRAALTDFIRETQDDVWRLLAHLGGHEIADDLTQETYLRVMGALPRFAARSSARTWLLSLARRVWVDNIRHDMARPRKSIVEYENTGATDASNAGIWSEWIDVRTLIDALPPERREALILTQVLGYTYEEAAKIADVRVGTIRSRVARARADLISATAAGDSSEEDGKSAQG
>NZ_AP017369.1|WP_096453847.1|404014_405565_+|catalase
MSEQSAVDQIVDRGMRPKLSGNTTRHNGAPVPSENISTTAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSQYTKADLFQPGKVTPLAIRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRTPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAEVAGQNADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARVFAYADQQRYRIGPNYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGQDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEETEPRVYDYWNKVDENLGARVKELYLQKKA
>NZ_AP017369.1|WP_096453849.1|405644_405938_-|hypothetical-protein
MRMKSIAAIAITTAALAGGTGVASAQEAGSTTGSSNLSSGIQLPQEVTDLLSFLPAAQAAQVEGAIQSTAGFFAVGLGSTAIGSTAVTLGIADLLSS
>NZ_AP017369.1|WP_167381992.1|405989_406445_-|Lrp/AsnC-family-transcriptional-regulator
MKLDSIDRAIIAELSANARISNLALADKVRLTPGPCLRRVQRLEAEGIILGYSADIHPAVMNRGFEVTVDVTLSNFDRSTVDNFESSVAQHDEVLELHRLFGSPDYFVRIGVADLEAYEQFLSNHIQTVPGIAKISSRFAMKVVKPARPQV
>NZ_AP017369.1|WP_096453853.1|406519_407275_+|AzlC-family-ABC-transporter-permease
MQKTQEIHSSLEVSASKAALEPGDKGYRRYEIAQGLKTSLAAGLGMYPIGIAFGLLVIQYGYEWWAAPLFSGLIFAGSTEMLVIALVVGAAPLGAIALTTLLVNFRHVFYAFSFPLHVVKNPIARFYSVFALIDEAYAVTAARPAGWSAWRLISMQIAFHSYWVFGGLTGVAIAELIPFEIKGLEFALCALFVTLTLDSCRTKKQIPSLLLAALSFTIALVVIPGQALFAALLIFLGLLTIRYFFLGKAAK

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Crispr_ID: NZ_AP017369_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_4

490666-490815

Orphan

Consensus_repeat	Method
GGACCATCCCCACGTGTGCGGGGAGAAT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP017369_4

>merge|NZ_AP017369|4|490666-490815|CRISPRCasFinder
GAACTATCCCCGCGTGTGCGGGGAAAACGCCCGCAACTTTGCGGTCGGCGCCGTCCCAGAGGGACCATCCCCACGTGTGCGGGGAGAATGACTGGCACAGACGAATCTACGACCCCAACGACGGACCATCCCCGCGTGTGCGGGGAGAAT

>NZ_AP017369|4|4|490666-490815|CRISPRCasFinder
GAACTATCCCCGCGTGTGCGGGGAAAAC	GCCCGCAACTTTGCGGTCGGCGCCGTCCCAGAG
GGACCATCCCCACGTGTGCGGGGAGAAT	GACTGGCACAGACGAATCTACGACCCCAACGAC
GGACCATCCCCGCGTGTGCGGGGAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096454015.1\|499142_499601_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096453983.1\|481699_482065_-\|DUF2304-domain-containing-protein	unknown	unknown	gnl\|CDD\|378376
NZ_AP017369.1\|WP_096453997.1\|490281_490506_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_167381999.1\|498724_499165_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_AP017369.1\|WP_096454005.1\|494384_495404_-\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224013
NZ_AP017369.1\|WP_096454011.1\|498086_498578_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454001.1\|492168_493026_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NZ_AP017369.1\|WP_096453999.1\|491037_492099_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176186
NZ_AP017369.1\|WP_096453985.1\|482851_483874_+\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|223405
NZ_AP017369.1\|WP_096459609.1\|482061_482772_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NZ_AP017369.1\|WP_096454003.1\|493022_494381_-\|sugar-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|224016
NZ_AP017369.1\|WP_096459612.1\|487362_487626_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|377579
NZ_AP017369.1\|WP_096453991.1\|487710_488019_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227893
NZ_AP017369.1\|WP_096459615.1\|499628_500882_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454009.1\|496775_497723_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_AP017369.1\|WP_096453989.1\|485107_487159_+\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|223808
NZ_AP017369.1\|WP_096453993.1\|488867_489176_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454007.1\|495441_496023_-\|dehydrogenase	unknown	unknown	gnl\|CDD\|380327
NZ_AP017369.1\|WP_096453987.1\|483911_484949_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NZ_AP017369.1\|WP_096453995.1\|489184_490057_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096453983.1\|481699_482065_-\|DUF2304-domain-containing-protein	gnl\|CDD\|378376	pfam10066, DUF2304, Uncharacterized conserved protein (DUF2304). Members of this family of hypothetical archaeal proteins have no known function.	2.91981e-26
NZ_AP017369.1\|WP_096453985.1\|482851_483874_+\|ribonuclease-HI	gnl\|CDD\|223405	COG0328, RnhA, Ribonuclease HI [DNA replication, recombination, and repair].	8.22075e-24
NZ_AP017369.1\|WP_096454001.1\|492168_493026_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	1.43237e-161
NZ_AP017369.1\|WP_096453999.1\|491037_492099_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.25885e-180
NZ_AP017369.1\|WP_096459609.1\|482061_482772_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	3.32854e-43
NZ_AP017369.1\|WP_096454003.1\|493022_494381_-\|sugar-nucleotide-binding-protein	gnl\|CDD\|224016	COG1091, RfbD, dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane].	9.30571e-97
NZ_AP017369.1\|WP_096459612.1\|487362_487626_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|377579	pfam05973, Gp49, Phage derived protein Gp49-like (DUF891). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	2.20296e-17
NZ_AP017369.1\|WP_096453991.1\|487710_488019_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|227893	COG5606, COG5606, Uncharacterized conserved small protein [Function unknown].	2.34531e-19
NZ_AP017369.1\|WP_096454009.1\|496775_497723_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	7.09887e-75
NZ_AP017369.1\|WP_096453989.1\|485107_487159_+\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|223808	COG0737, UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism].	1.85829e-96
NZ_AP017369.1\|WP_096454005.1\|494384_495404_-\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|224013	COG1088, RfbB, dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane].	0
NZ_AP017369.1\|WP_096454007.1\|495441_496023_-\|dehydrogenase	gnl\|CDD\|380327	cd03370, nitroreductase, uncharacterized nitroreductase family proteins. Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	2.07541e-33
NZ_AP017369.1\|WP_096453987.1\|483911_484949_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	7.94794e-52
NZ_AP017369.1\|WP_167381999.1\|498724_499165_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.00381e-11

>NZ_AP017369.1|WP_096453997.1|490281_490506_-|hypothetical-protein
MDEKEVLSRLSKDTGWSFKQATLLDNGVWVGWPNNDMTGSAPALLHLDGTVEALSSSPLDWPDYLLEHVENLED
>NZ_AP017369.1|WP_096453995.1|489184_490057_+|hypothetical-protein
MNKGPKTLEEKAEPIKQGSIKLLDFWPHILLGSIPIISLFVTIFPDANFKFFNWDISIPYALTGLTFVFAICGGVGMYFRTQSLHAAQQRCKELEKDLHQARSLAKSYQSDVQSALKFALQQLAFDIGLSRDVGSSRSLHFELRITLYCHHPKRNTFIPIARIAGDPTLEKFGRSEYPDSQGAISRGWKTGGVVLTSLPEDRAIWELELVENYGFLPDEASSIVMQSLSMLATRLNAESGPIGVIVVESTKKRGVSARTMDALQDSTWYAPIASLMVSVQESLVPHISEN
>NZ_AP017369.1|WP_096453993.1|488867_489176_+|hypothetical-protein
MKESNSSRFEARCFFYVSPATHRDSFIESIREWLLINEAPNAMSVSPMPAGQDQVILNIGVEAKNYSDAESMIDRFIDSLIAGTGYNSGGSVHRGSELLASA
>NZ_AP017369.1|WP_096453991.1|487710_488019_+|XRE-family-transcriptional-regulator
MNDRAGNVWDFLSDTPGEAENLRLRSQLLSRINERLDEFGWSQKVSGENLDLTQPRVSDLMNGKISKFSLDALVNIGIKVGVHMRVDDSESNVVPTHKVGSR
>NZ_AP017369.1|WP_096459612.1|487362_487626_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MPLLFASDGVLRELRSLPKEAQQDTGYQLQRVQWGHGPTNWKPMSDVGPGCREIRLTTSDGIARSIYVYVGKNPKYVVCLCAFVKKT
>NZ_AP017369.1|WP_096453989.1|485107_487159_+|bifunctional-metallophosphatase/5'-nucleotidase
MKRLSRAALAVVATTAVSFSALAVPASAVEANNVELNILGVTDFHGHIQQNLGDGEMGASGVACYVDAERKANPNTSFITVGDNIGGSPFVSSILKDEPTLQALNAIGVDASALGNHEFDQGYSDLVNRVSLDGSGSAKFPYLGANVEGGTPAPAKSEIIEMDGVKIAYVGAVTEETATLVSPAGIEGITFTGDIDAINAEADRVINEGEADIVIALLHAEAAPTDPFSNNVDVVFSGHTHFDYVAEGEARSDKQPLVVIQGHEYGKVISDVEISYDLEARKINNIEARNVPAAEVVENCTTPNAEVDGIVAAAVGAAEVEGAKVVTTIENGFYRGANAGQATGSNRGVESSLSNLIAEAGLWAVNDATSLNADIGIMNAGGVRADLEAGEVTFADAYATQNFSNTYGARDLTGAQFKKALEQQWKETGDRPRLALGLSNNVQYSYDPERAYGDRITHITINGEPIDLDATYRITGSSFLIAGGDSFTAFAEGGPIAESGMVDIDLFNRYIAAHPDVEVRANQSSLGITLSGPGVAEDGTLVAGEELTVDLSSLSYTGPEEKPSTVEVAVGSEKQTAEVDNTIIDQLDLTGTASVTLTVPAGATSIKLATDNGTTFELPVSVNGEGNNDDDNEPQPSGSSDAGSLVAVLGVLGALGGLLAFFLNSAQGAPFLTQLQAMLAQFM
>NZ_AP017369.1|WP_096453987.1|483911_484949_+|glycosyltransferase-family-2-protein
MSNKRIGVVIVSYGHEQDVANLVDTFADQLKTGDRVVVVDNRKPWVLKEAVGERLEKHGVEIIDHDNGGFAAGCNVGAARIVDDVDLLFFLNPDTVIDDPTLFNTLRSVDEQWAAFMPYLLLPDGTINSAGNALHISGLSWVTGMDEKPAEGSSEVTDISIASGACLAVRVDWWKRLGGMEEMYFMYHEDTDFSARLLLAGGRIGLVHSAYVTHHYDYAKGDYKWIYIERNRHVLLLSVLPLPLLLALTPQILGVNLGLWAIAARENRLGLKVKSLRLLIRDLPAIFKLRSRTQKLAELTPSQYLAKMEWRLDNPYLGSIGKNKVVATVYKTYYKLCLSVLKLVA
>NZ_AP017369.1|WP_096453985.1|482851_483874_+|ribonuclease-HI
MKSIDLEQLAGTQSRTYQSRKITEEMVARPVHVAIALWEVPWESANSGKIEGWVIAVDSSRGRFVRSGQTKNGDAIKKTISMLKSALRGVRGKAWIVTGRRQAALRAALVRENYLVTGSFAEQNRAGAKASAISRRAEQSALYKAKKIGEFAERAPRVKERQEAHWWPRLSRTEGHAGVLRLATDASTDGVFRGAMCFVASNGDYLLETSDTTASSDELELESITHALIYLKTIGATHAKIESDSKAALEAIDFILNTRPRRGRWRGITARARNRFKDAWDSLIDECVVELSRVLGHAGDPLNQAADQIAYMGMRAVIFEQKSAHPTLLKGIEKALRKAE
>NZ_AP017369.1|WP_096459609.1|482061_482772_-|glycosyltransferase-family-2-protein
MDASKNSDFSDTWLVVPCYNEGTVIREVLENARKTFPNIVAVNDGSPDNSAEEIHAAGAHLVNHPVNLGQGAAIQTGIEYARAQPGAKYFVTFDADGQHQVKDVVKMIERLRAEDVDIIVGTRFGRPRQADDQVPLIKRIVLRTVVMLSPQTRKLGLTDAHNGLRVFNQKVAQEINIRMNGMSHASEIVDQIAELGWRISEEPVDILYTEYSMSKGQSLLNGVNILADGFLARRLP
>NZ_AP017369.1|WP_096453983.1|481699_482065_-|DUF2304-domain-containing-protein
MTQTTTQIIIQVLLLLATAALALYFLKNRRKARAKAWVKIGFVVFIFAAVWAVIRPDDLTQLANFVGVDRGTDLMLYALVVAFMFTTLSSYVRFREQELRYSKLARAVALQNAVLPEESAD
>NZ_AP017369.1|WP_096453999.1|491037_492099_-|NAD(P)-dependent-alcohol-dehydrogenase
MSISVKALQKSGPEAPFEVKTIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGSDVTKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSTDVDGTITQGGYAEKVVVNERFLCSIPEELDFDVAAPLLCAGITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGAEVTVLSRSLRKAELAKELGAARTLATSDEDFFKEHAGEFDFILNTISASIPVDKYLGLLKPQGVMAVVGLPPEKQDLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIETVGVDEVDAAYDRVVAGDVQFRVVIDTASFAGAEAV
>NZ_AP017369.1|WP_096454001.1|492168_493026_-|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGINDVLIITTPEDSDSFKRLLGDGSSWGISLSYAVQPSPDGLAQAFIIGEEFIGDDDVALVLGDNIFDGAQLGRALKQCANPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKPTAPKSNFAVVGLYFYDNRVVEIAKNIEPSERGELEITSINDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQKRTGNIIGSPEVAAYREGFITSSELAALGEELKKSGYGNYLLRAL
>NZ_AP017369.1|WP_096454003.1|493022_494381_-|sugar-nucleotide-binding-protein
MFNKELTMRETDIDGLLIFDFPVHGDNRGWFKENWQRTKMTTIGLPDFGPVQNNMSFNATAGTTRGMHAEPWDKFVSVAVGAVFGAWVDLREGSETYGNVVKQKITPDVGVYVPRGVANGFQALEDGTLYTYLVNDHWSPDAEYANVNLNMIDWPLPITEISDKDKKHPTLIDATPLPARKVLVVGAGGQLGTALRAQFPDAEFVTRAELDITADLTDARAWKQYSTIINAAAYTAVDQSEEDRATAWSINATAVGNLAAIARENNLTLVHVSSDYVFDGTAESYDETAPLSPLGVYGQTKAAGDIAAATAPRHYIVRTSWVIGDGNNFVRTMKSLDERGIAPSVVDDQIGRLSFTQDIAAGIAHLLKSGAEYGTYNLTNSGQPASWADIARAVFTDPSRVTGVSTAEYFADKNAAPRPLNSVLELNKIEATGFSAPTWQTRLNDYLKELSK
>NZ_AP017369.1|WP_096454005.1|494384_495404_-|dTDP-glucose-4,6-dehydratase
MTSLLVTGGAGFIGANFVRQTVEQHPEYTHITVLDKLTYAGNADNLKGLPDSKVTLVQGDICDAELVDTLVKDHDITVHFAAESHNDNSLNDPSPFVHTNLIGTYTLLEAVRKHNKRFHHISTDEVFGDLELDDPNRFTETTAYKPSSPYSATKAGSDHLVHAWIRSFGIQATMSNCSNNYGPYQHIEKFIPRQITNILAGLTPKLYGTGEQVRDWIHVDDHNDAVHLILKKGKIGETYIIGADNDHVNNKQVIELICELMGLGKDAYEHVADRPGHDMRYAMDSTKLRTELGWEPKYTDVNSGMRQGLEQTINWYRENEAWWRSAKDTVEATYAKQGQ
>NZ_AP017369.1|WP_096454007.1|495441_496023_-|dehydrogenase
MSLSVVEAITNRRATRKYTDEAPTPELIDKIVNLALEAPSAFNAQQREIVVITDPAQKQKLYEASHQKQFLTAPVTFIAVARVENEPEDLEEILGAERAERVAGFINGRSIQQAREATLRDASLAAAFLILAAQAEGLSTSPTTGWDEEKVKEAIGIGGREDRAIALVIAAGFPNEQPEHPGRLQNRRIDNSY
>NZ_AP017369.1|WP_096454009.1|496775_497723_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MHFCLLPLARPAKVVVPLLGAALLLSSCSSTSSDESIQPEVASTGYSVEHAMGTAEIPETPTRVVVIDSPHLDALLALGITPVGATESGSENGFPAYLADELKDTESVGLTSEPNLEKIAALDPDLIIGAKVRHEAIYDQLSDIAPTVMSEGSGTNWNEQAEITAAAVNKSDEMDKLIADLDTRAKDLGEEIGAEGQTASMVRFRPDNFRLYGPETFSGSVLEQVGFELGERDWNEYSMMELSPENFGQIDGDLIFYTIPGSPEATTYPQVSELWVDSPAVQQGKTYEFEDETWMVGIGVLGANEILDDLEETLS
>NZ_AP017369.1|WP_096454011.1|498086_498578_+|hypothetical-protein
MANWKKSVAHLDGDQCEIRWGWMTVLEEQRFLELEEADEDAFIEFSVLIESACLGILNPDQTRINFPLNKNYSRKWSFDEVPWIGEWKVDSFKRRGGCYRIYFTDVLDGHDGVFFPMIGLLFREYPQKNLKFEAQSADIDRAITLAMKHQREHHCVLRTMWLR
>NZ_AP017369.1|WP_167381999.1|498724_499165_+|helix-turn-helix-domain-containing-protein
MWISQLVCLRKQKGLSQADVAKKIDVDQSTISRLENQNSGERNVQTRLLEKYARAIGAYVGHVVIDAEAGDSYQRLQQELEEHTRALITQSTKRSDAKTVYQVTDIMSHNSAVYSNSLVATRDTRIRWIETSNTEKQGNNGFTLSR
>NZ_AP017369.1|WP_096454015.1|499142_499601_+|hypothetical-protein
MGLHSPDELQKEAKEFVCQWDKVSFKRFVKDDEALKKNSQVEIDAVYSVSETVFLFKLDVNITRPTSLEEFTLLVGYEYEKEISPSHQESIDLVVEKLGPIAFEILNQEVVRLGAYSMESPARISIRDQANFWEYFCNQPEEEISMRSRALN
>NZ_AP017369.1|WP_096459615.1|499628_500882_-|hypothetical-protein
MRYLTLATIIAGLSGFVVIIIAAWALGDSSQLSEEFTAYWGLFFAGTGVLTGLTQETTRAVTAGQARAGASGVAGVSVGFRPFLFSFVVAAIVLVVLGASAPLWIGQLLSSLQGVGVGLLAVGLASYAIQATISGILSGCQLWKEYALLISLDTGVRMVLAVAAWLLGYQLLAFLIITVVGSISWLVIVLCFGSVRSVLGSVADVSRGIFIRQALLAMAASGATAVLITGFPTLLKFTSPSAVAGGVSMAAVSYAVILTRAPLLVPLQQFQSAIIVRFVKGASGPLKTLAGPLAIVWAVGIVGAGLAWLVGPWILDVVLQKELFAVPGWLLAMLTLGATTTASLMVSGCAAIAFERHGIYLAGWVIATIVAVGFLLGPFDLGVAAGLALIVGPLCGLLVHMGAFVGGDRKKRVLAAG

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Click the colored protein region to show detailed information

Crispr_ID: NZ_AP017369_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_5

603499-603597

Orphan

Consensus_repeat	Method
CCAAACCAGGAGACCCAGGATCAGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_5

>merge|NZ_AP017369|5|603499-603597|CRISPRCasFinder
CCAAACCAGGAGACCCAGGATCAGGATATTTGAAGATTTCGGGTCTCCTGGTTTGGTGGATCACGCTGAATGCCAAACCAGGAGACCCAGAATCAGGAT

>NZ_AP017369|5|5|603499-603597|CRISPRCasFinder
CCAAACCAGGAGACCCAGGATCAGGAT	ATTTGAAGATTTCGGGTCTCCTGGTTTGGTGGATCACGCTGAATG
CCAAACCAGGAGACCCAGAATCAGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096454172.1\|604022_604907_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP017369.1\|WP_096454180.1\|608970_609822_+\|quinate/shikimate-dehydrogenase-(NAD+)	unknown	unknown	gnl\|CDD\|172521
NZ_AP017369.1\|WP_096454164.1\|598981_600049_-\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|273654
NZ_AP017369.1\|WP_096454168.1\|600539_601934_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NZ_AP017369.1\|WP_167382007.1\|611569_613177_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_AP017369.1\|WP_167382005.1\|595149_595962_+\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|237008
NZ_AP017369.1\|WP_096454158.1\|594260_595088_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766
NZ_AP017369.1\|WP_096459636.1\|603060_603333_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_003855509.1\|596211_596403_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_AP017369.1\|WP_096454178.1\|608518_608950_+\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|376496
NZ_AP017369.1\|WP_096454182.1\|609826_610102_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223300
NZ_AP017369.1\|WP_003855542.1\|596725_596827_+\|AURKAIP1/COX24-domain-containing-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454184.1\|610528_611569_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_AP017369.1\|WP_096454188.1\|614958_616743_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|224503
NZ_AP017369.1\|WP_096454162.1\|597052_598852_-\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_AP017369.1\|WP_096454186.1\|613184_614261_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270265
NZ_AP017369.1\|WP_096454176.1\|606601_608458_+\|dehydroshikimate-dehydratase-QsuB	unknown	unknown	gnl\|CDD\|225726
NZ_AP017369.1\|WP_167382006.1\|600217_600454_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NZ_AP017369.1\|WP_096454170.1\|601935_602844_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_AP017369.1\|WP_096454174.1\|605180_606602_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096454172.1\|604022_604907_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.15754e-32
NZ_AP017369.1\|WP_096454180.1\|608970_609822_+\|quinate/shikimate-dehydrogenase-(NAD+)	gnl\|CDD\|172521	PRK14027, PRK14027, quinate/shikimate dehydrogenase (NAD+).	0
NZ_AP017369.1\|WP_096454164.1\|598981_600049_-\|HAD-IB-family-hydrolase	gnl\|CDD\|273654	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490. This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI\|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI\|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity].	5.23181e-82
NZ_AP017369.1\|WP_096454168.1\|600539_601934_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.2616e-156
NZ_AP017369.1\|WP_167382007.1\|611569_613177_-\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.39143e-98
NZ_AP017369.1\|WP_167382005.1\|595149_595962_+\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	2.27411e-119
NZ_AP017369.1\|WP_096454158.1\|594260_595088_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	4.00504e-06
NZ_AP017369.1\|WP_003855509.1\|596211_596403_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.38499e-16
NZ_AP017369.1\|WP_096454178.1\|608518_608950_+\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|376496	pfam01220, DHquinase_II, Dehydroquinase class II.	3.48912e-82
NZ_AP017369.1\|WP_096454182.1\|609826_610102_-\|hypothetical-protein	gnl\|CDD\|223300	COG0222, RplL, Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis].	8.16897e-14
NZ_AP017369.1\|WP_096454184.1\|610528_611569_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.57307e-122
NZ_AP017369.1\|WP_096454188.1\|614958_616743_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	gnl\|CDD\|224503	COG1587, HemD, Uroporphyrinogen-III synthase [Coenzyme metabolism].	3.6953e-64
NZ_AP017369.1\|WP_096454162.1\|597052_598852_-\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.63024e-74
NZ_AP017369.1\|WP_096454186.1\|613184_614261_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270265	cd13547, PBP2_Fbp_like_2, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.09348e-97
NZ_AP017369.1\|WP_096454174.1\|605180_606602_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.62774e-157
NZ_AP017369.1\|WP_167382006.1\|600217_600454_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	1.01102e-13
NZ_AP017369.1\|WP_096454170.1\|601935_602844_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	1.42576e-132
NZ_AP017369.1\|WP_096454176.1\|606601_608458_+\|dehydroshikimate-dehydratase-QsuB	gnl\|CDD\|225726	COG3185, COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only].	4.7201e-129

>NZ_AP017369.1|WP_096459636.1|603060_603333_+|hypothetical-protein
MRIPRKAIRKIEVVDNIIDSVDHPIKRAGRLRIPGVFVAGTHAHVNETEFSMCRKNAPGLVIELENISINRIVISTPHAHRYADELMVVA
>NZ_AP017369.1|WP_096454170.1|601935_602844_+|hydroxymethylbilane-synthase
MTLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDVLHAGECDVAVHSMKDLPTAADPRFHLVVPTRADSREALIARDGLTLAQLPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDADVIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAHATLGGYSGDTMTLTAGVFALDGSDQLVFTAEGDGARPEELGELVAQQLIDAGAPDLLGERS
>NZ_AP017369.1|WP_096454168.1|600539_601934_+|glutamyl-tRNA-reductase
MVSVLIVGMSHRSAPVALLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEVSGVDIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQVANECGSVGPALHSLTQTALHTGKRVHTETAIDDAGASMVSFAVDRALVQMGLDPEAEAPLAGKTALVLGAGAMSSLAATHLGRAGISSLIMANRTLERAERLAQHSMEAGVPAHVVDYDQRASVYGDVDVIISATGAGEFTVKPADIPAGSELMLIDLSMPRDIDDACADLPGVDLVNIERLHKVSREGGAGVTPSEQEALKIVREELDSFTSEQRIRDIVPAVSALRKQAASVGSDELDRLRMRTPGISDTEWVEVEKTVRRVVDKLLHEPTVRVKELAARSGSISYESALQELFGLDAPASTAAPATTAVNASELPDAGIVAVVNAPSATQTRE
>NZ_AP017369.1|WP_167382006.1|600217_600454_+|glutaredoxin-family-protein
MGHSVEIIVRDNCGSCTRVKAQILPVVEAAGIKLTERNVDQDASLKLEFGDRVPVILVDDEEFACWEVDNDELANALL
>NZ_AP017369.1|WP_096454164.1|598981_600049_-|HAD-IB-family-hydrolase
MSPQGKNPDWDYAAIGTPEDFLASWSASRGNLRRFFEDHAAAPINDAAQRQAGEAAATQAVAAIYGMELNEFNAGIDAVTGAIESAGAIHVSTPDPDVPQDIGAAAFFDVDNTLIQGSSLIVFAQGLFRKKFFTIKEILPVAWKQLKFKLTGSENADDVSRGREQALEFIKGRPVQELIDLCEEIVDQRMVDKMWPGTKQLADMHIAAGHQVWLVSATPVQLAQILAQRLGFTGAIGTVAEAKDGVFTGRLVGDILHGPGKRHAVAALASIEKLDLTRCTAYSDSINDLPMLSMVGTAVAVNPDSKLRKEAETRGWDVRDFRSIRKATRAYGIPALVTAAFSVTGWRLRRRWRKH
>NZ_AP017369.1|WP_096454162.1|597052_598852_-|IS30-family-transposase
MTSREQPTTQEAVRRIADGQRVKDVALDLGIHPSTIYLALKRHGLPVDKTAPHRVLNPQTNRHIPKNTEHPTTTEAVARVKRGERVKNVAKELGIHPSTIYLALKRHNLPVGKNAPHRVLNPQTNRHIPNTTERPATTEAVTRVNRGERVVTVAKELGLHPSTIYTAIKRREEATDTPTPPGKKGEGNHRCSDTPAPTTTTTQSRCTTTEVPDLSCCSNDSVSSRTADHVVADFSLVPDTRVKTGRGVRLSSTDRLVIAQGIKERLSTRQIGTKLGRHHSVIAREINRGSTTYLDPDTQEIKQLVYNPQTAHYHAQQQARRPKERKLDRPGRLRDVVVEYLLRYFSPKRVEQRLLLDYPDDKSMHISHEAIYQSLYVQGRGSLREIIEEELRQREMNTNKVLIRGGKTRRPRSKIAGLRNRRGWVVGAEITTRPPEADDRRVPGHWEGDLVIGAGGQSALLTLVERSSRFTLLKHLPDDHASSTVVGALQEMIASMPGKFSTITWDQGSEMASARKVIDPAECGIYFCDPHSPWQRPTNENTNGEIRRRFYPKGTDFREVTPEHVAWVQDELNDTPRLVLGAMTPYEKMNEVLTVATTQ
>NZ_AP017369.1|WP_003855542.1|596725_596827_+|AURKAIP1/COX24-domain-containing-protein
MGSVIKKRRKRMSKKKHRKMLRRTRVQRRKLGK
>NZ_AP017369.1|WP_003855509.1|596211_596403_+|helix-turn-helix-domain-containing-protein
MAREDNGTFLTVAEVAEIMRVSKMTVYRLVHSGELPAVRVGRSFRVHEKAVNEYLDSSFYEAG
>NZ_AP017369.1|WP_167382005.1|595149_595962_+|pyrroline-5-carboxylate-reductase
MTTIAVIGGGQIGEALVSGLVAADMNPQNIRVTNRTEERGQELRERYGIVNLTDNAQAVDEADVVFLCVKPKFIVEVLSEITGTLDNNSAHSVVVSMAAGISITTMEESASAGLPVVRVMPNTPMLVGKGMSTVTGGRHVDDEQLKLVKELLGTVGDVLEVAESDIDAVTAMSGSSPAYLFLVTEALIDAGVNLGLPRATAKQLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAAIRELEESGIRGAFYRAAQACADRSKELGKH
>NZ_AP017369.1|WP_096454158.1|594260_595088_+|hypothetical-protein
MSEEKLTVAELMARAAKEGRSTDAPRRRRRRSIEDGGVSVAELTGSIPAVKEKPAESRHSSVPIDAPAQPVEPEEEPQEVAEVVEAPETPETPETPEAEEGVEKQEEAPARPAPSNDETMVLSIVDEKDPITLTTGAFPVVPAVAAKPAPVVRADKDADAETAAQADFADDEPEENTETTTFEAEVEDESENKMSVFSIIVMAIVGIVLGVVVFLGFEMLWERLNKWLVAVLAVGVTLGMVGIIHALRTSRDGFSMVLAGIVGLVMTFGPLAIVM
>NZ_AP017369.1|WP_096454172.1|604022_604907_-|LysR-family-transcriptional-regulator
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKAGEILHEEALRTLSRMQSVVDEIQSGEHLITSIKIGVPPGIPIDWLRTQLIDLGPEIRISLIESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHKQELGIVIRCDSELHQQLVGRDNATLFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVKADVALTTEESARTNFPSWRWVPLEAEDASGNDLIVRTWITWNPQPSPAVRDLIQKFIDAI
>NZ_AP017369.1|WP_096454174.1|605180_606602_+|MHS-family-MFS-transporter
MSEQLQGVTHSETTPGKTPKRAALSSWIGSALEYYDFAVYGTAAALVLNHLFFPADTSPGIAILAAMGTVGVAYVVRPLGALIMGPLGDRYGRKFVLMLCLFLIGASTFAVGSLPTFEQAGYLAPALLVLCRVIQGLSASGEQSSAISVSLEHADEHRRALTASWTLHGTQFGTLLATAVFIPFTLFLSEDALMSWGWRVPFWLSAVVVLVAFLIRRGLQEPPAFRENKEAVAGGPSPLAMTLRYHKAAVARVAVAAMINSVNVVFTVWALSFATNIVGLDRSTVLLVPVVANLVALIAIPLSGMLADRIGRRPVFIIGAVGAGLAMNGYLGAIYAGNWTMIFFMGVLMSGLLYSMGNAVWPSFYAEMFPTSVRVTGLALGTQIGFAVSGGFVPVIASALAGEQGDQWVKVAIFVGVTCVISALVAMTAKETKSLTLDEIDALHTARSEAADLAAGAAATTAQTVQKEKEALH
>NZ_AP017369.1|WP_096454176.1|606601_608458_+|dehydroshikimate-dehydratase-QsuB
MRTSVATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLFQPFRDFEGVEEEEFQKNLHRLEAKFQLMNRLGIEMILLCSNVGTATINDDDLFVEQLRRAGDLAAKYNVKIAYEALAWGKFVNDFEHAHAIVEKVNHDCVGTCLDTFHILSRGWATDAVENIPAEKIFFVQLADAPKLAMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEIFNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNPEDRPSALELQALPEVAEPAGVDFLEIATGRLGETIRVLHQLGFRLGGHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDTPDPEAAHARAELLRAKTIDRPHIDGEVDLKGVYAPDGVELFFAGPSPDGFPEWLPEFGVDKQETGLINGIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPNDAVRLLLSVAPEDGEQGDFLNAAYPEHIALATDDIVAVAQRARKRGLDFLPVPENYYDDVQARFDLPEEFLDTLKENNLLYDRDEHGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPVRLAAQYREVRDLERGIPS
>NZ_AP017369.1|WP_096454178.1|608518_608950_+|type-II-3-dehydroquinate-dehydratase
MSGKILLLNGPNLNMLGKREPEIYGHDTLEDVVALVTAEAAKHGLEVEALQSNHEGELIDALHKARGTHIGCVLNPAGLTHTSVALLDAVKASELPTVEVHISNPHAREEFRHHSFISLAAVSVIAGAGIQGYRYAVDILANL
>NZ_AP017369.1|WP_096454180.1|608970_609822_+|quinate/shikimate-dehydrogenase-(NAD+)
MHNTILLGLIGEGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGVRASGRDLKTLLDAAISLGFNGLNITHPYKQAVLPLLDEVSEQATQLGAVNTVVIDAEGRTTGHNTDVSGFGRGMEEGLSNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLDTSRAQALADVINDAVGREAVVGVDARGIEDVIAAADGVVNATPMGMTAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKAARALGCETLDGTRMAIHQAVDAFRLFTGLEPNVERMRETFLSL
>NZ_AP017369.1|WP_096454182.1|609826_610102_-|hypothetical-protein
MFGRKDVNLSALEARVAALERRLAEQDQIIAQLGGDSSTPLSLQRPQSGLHPEVVALLQQGKKIAAIKRHRELTGAGLKEAKETVEASKYY
>NZ_AP017369.1|WP_096454184.1|610528_611569_-|ABC-transporter-ATP-binding-protein
MSSINLRDLSVRFRDGSFGLRDINLEINPEEFVVLIGPSGSGKTTMLRTLAGFVQPSSGNVYIGGQNMTHVPPERRGMGMVFQQHAVWPHMSVAKNVGYPLARKGEKGASISKRVERTLALVGLEGFGRRKPASLSGGQRQRVALARAIIADPTVLLLDEALSALDEPLRDALRRELVSLTRREGLTTVHVTHDRAEAISIADRIVMLGDGRIHQVATPAELLSAPATADVARFIADATVLSGTIKGGKVVCAELDLSWDLSAVQAIDEVAEGDGVDIAIPPQSLSIGGSSVHAEITSVLFQVTSYSVTATTQSGHNFRLSISGQVPKIGETIQLMVRNPLVYRAF
>NZ_AP017369.1|WP_167382007.1|611569_613177_-|iron-ABC-transporter-permease
MQLTQPALSLMRLGVWLIVAGVFITPLALVVGLALGGNQLPTLLDSGLGQALWNSTYTTFLSALGATVVGTLMALTLDRTNVFGRTALRLFLLSPLLIPPFIGAIAWLQLFGRNQGINRFFGTDVWDIYGADGVTFLLIVHSYPTVYIIVSAALRQLPGDLEQAARISGAHTFTVLRTITVPLLKPALLSAFTLTAVANLADFGIPALLGSPARFETLATMIYRFMESGTVSNPLQVVSTIGIVLLFLGIAAVTADYVVSLYASSKLQDAGQSYRFELKQSRIPVSALTWIIALVITAAPLLGLAYRALLPAPGVPFTLNTITLNNFAAALNNPRVIEGFSNSLMLSLGAALICGVLGWLIGVLITRTTHFANVPLTLLVLLPTALPGMIIGVGWLILGRYTDLYNTPWVILGAYVCAFTALVVQAVRGPLSQAPEAIEEAARISGAGRLKSIMDTTAAMAIPAAFAGAVLVAVTAVRELTVSILLIAPGTTTLGVQVFNLQQAGNYNQASALSLMFAILGIVALTLTVRSQKEF
>NZ_AP017369.1|WP_096454186.1|613184_614261_-|ABC-transporter-substrate-binding-protein
MSLKQTLKRTATTVLALGASAALLVACSEPSADTSADATGNASADSTGDATGDAITITAYTSEPEEKVDEINRAFMMANPDIKVEVYRAGTGDLTARIEAEKASGSVEADVLWAADAATFESYAAQGDLAELSDVDTSSVIDEALDAENFYVGTRIIPTVIAYNTEAIDQAELPTSWADLTDPKYAGQLVMPDPAVSGAAAFNASVWKNDPALGEDWITALGENQPMIAQSNGPASQEIAGGGHPVGIVVDYLVRDLAAAGSPIDTIYASEGSPYITEPAGVFADSDKKEAAQRYINFLLSAEGQEIAIEQAYLPVREDVGTPEGTPELADIELMTPDLEVVTADKAAAVEFFQNAMN
>NZ_AP017369.1|WP_096454188.1|614958_616743_+|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase
MTIAHKPETAETTGIETNQVSETIGVESLTHGNLRSVSSTEGQTEELLPGKVIFVGAGPGNPDLLTVRAREVLGNTVRTITDEQVLEGVRAFVATEIPVPEDKLQAAEDEYERICIEAKENGARRKPARPAPPTAAEITEVADATPAQIVELVQEALAHGGDVIRLVTGNPLSSDTTLAEISAVSEAGMEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQDLDWDQLASAPQPLVLQARMQDLSRIAEELKARNMPADTPVSVTANGTTRLQRTYDTTLGLLHKLDAELNGPLVVTLGKGVDDRSKYSWWENRALYGWRVLVPRAKEQAASMSERLSSHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTNLGWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHQRTIVACIGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS

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Crispr_ID: NZ_AP017369_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_6

610282-610375

Orphan

Consensus_repeat	Method
TTTTGGGTCGCCTGGTTTGGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_6

>merge|NZ_AP017369|6|610282-610375|CRISPRCasFinder
TTTTGGGTCGCCTGGTTTGGTTGTCGCGCTAAATACCAAACCAGGAGACCCAACTTTCAGGTTTTTGAGAATTTTGGGTCGCCTGGTTTGGTCG

>NZ_AP017369|6|6|610282-610375|CRISPRCasFinder
TTTTGGGTCGCCTGGTTTGGTTG	TCGCGCTAAATACCAAACCAGGAGACCCAACTTTCAGGTTTTTGAGAA
TTTTGGGTCGCCTGGTTTGGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096454184.1\|610528_611569_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_AP017369.1\|WP_096454180.1\|608970_609822_+\|quinate/shikimate-dehydrogenase-(NAD+)	unknown	unknown	gnl\|CDD\|172521
NZ_AP017369.1\|WP_096454198.1\|619527_622164_+\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_AP017369.1\|WP_096454168.1\|600539_601934_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NZ_AP017369.1\|WP_167382007.1\|611569_613177_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_AP017369.1\|WP_096454192.1\|617272_618292_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NZ_AP017369.1\|WP_096459636.1\|603060_603333_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454196.1\|618942_619455_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454178.1\|608518_608950_+\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|376496
NZ_AP017369.1\|WP_167382008.1\|616768_617194_+\|DUF3806-domain-containing-protein	unknown	unknown	gnl\|CDD\|372263
NZ_AP017369.1\|WP_167382009.1\|622286_623363_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_AP017369.1\|WP_096454172.1\|604022_604907_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP017369.1\|WP_096454194.1\|618322_618907_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454188.1\|614958_616743_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|224503
NZ_AP017369.1\|WP_096454174.1\|605180_606602_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_AP017369.1\|WP_096454176.1\|606601_608458_+\|dehydroshikimate-dehydratase-QsuB	unknown	unknown	gnl\|CDD\|225726
NZ_AP017369.1\|WP_167382006.1\|600217_600454_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|368604
NZ_AP017369.1\|WP_096454186.1\|613184_614261_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270265
NZ_AP017369.1\|WP_096454170.1\|601935_602844_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_AP017369.1\|WP_096454182.1\|609826_610102_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223300

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096454184.1\|610528_611569_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.57307e-122
NZ_AP017369.1\|WP_096454180.1\|608970_609822_+\|quinate/shikimate-dehydrogenase-(NAD+)	gnl\|CDD\|172521	PRK14027, PRK14027, quinate/shikimate dehydrogenase (NAD+).	0
NZ_AP017369.1\|WP_096454198.1\|619527_622164_+\|cation-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	2.67159e-162
NZ_AP017369.1\|WP_096454168.1\|600539_601934_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.2616e-156
NZ_AP017369.1\|WP_096454192.1\|617272_618292_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NZ_AP017369.1\|WP_096454178.1\|608518_608950_+\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|376496	pfam01220, DHquinase_II, Dehydroquinase class II.	3.48912e-82
NZ_AP017369.1\|WP_167382008.1\|616768_617194_+\|DUF3806-domain-containing-protein	gnl\|CDD\|372263	pfam12713, DUF3806, Domain of unknown function (DUF3806). This family represent the C-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1ma7 whose C-terminal domain is a phage integrase, pfam00589.	1.11163e-20
NZ_AP017369.1\|WP_167382009.1\|622286_623363_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	6.39239e-178
NZ_AP017369.1\|WP_096454176.1\|606601_608458_+\|dehydroshikimate-dehydratase-QsuB	gnl\|CDD\|225726	COG3185, COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only].	4.7201e-129
NZ_AP017369.1\|WP_096454172.1\|604022_604907_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.15754e-32
NZ_AP017369.1\|WP_096454188.1\|614958_616743_+\|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase	gnl\|CDD\|224503	COG1587, HemD, Uroporphyrinogen-III synthase [Coenzyme metabolism].	3.6953e-64
NZ_AP017369.1\|WP_096454174.1\|605180_606602_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.62774e-157
NZ_AP017369.1\|WP_167382007.1\|611569_613177_-\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.39143e-98
NZ_AP017369.1\|WP_167382006.1\|600217_600454_+\|glutaredoxin-family-protein	gnl\|CDD\|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	1.01102e-13
NZ_AP017369.1\|WP_096454186.1\|613184_614261_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270265	cd13547, PBP2_Fbp_like_2, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.09348e-97
NZ_AP017369.1\|WP_096454170.1\|601935_602844_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	1.42576e-132
NZ_AP017369.1\|WP_096454182.1\|609826_610102_-\|hypothetical-protein	gnl\|CDD\|223300	COG0222, RplL, Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis].	8.16897e-14

>NZ_AP017369.1|WP_096454182.1|609826_610102_-|hypothetical-protein
MFGRKDVNLSALEARVAALERRLAEQDQIIAQLGGDSSTPLSLQRPQSGLHPEVVALLQQGKKIAAIKRHRELTGAGLKEAKETVEASKYY
>NZ_AP017369.1|WP_096454180.1|608970_609822_+|quinate/shikimate-dehydrogenase-(NAD+)
MHNTILLGLIGEGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGVRASGRDLKTLLDAAISLGFNGLNITHPYKQAVLPLLDEVSEQATQLGAVNTVVIDAEGRTTGHNTDVSGFGRGMEEGLSNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLDTSRAQALADVINDAVGREAVVGVDARGIEDVIAAADGVVNATPMGMTAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKAARALGCETLDGTRMAIHQAVDAFRLFTGLEPNVERMRETFLSL
>NZ_AP017369.1|WP_096454178.1|608518_608950_+|type-II-3-dehydroquinate-dehydratase
MSGKILLLNGPNLNMLGKREPEIYGHDTLEDVVALVTAEAAKHGLEVEALQSNHEGELIDALHKARGTHIGCVLNPAGLTHTSVALLDAVKASELPTVEVHISNPHAREEFRHHSFISLAAVSVIAGAGIQGYRYAVDILANL
>NZ_AP017369.1|WP_096454176.1|606601_608458_+|dehydroshikimate-dehydratase-QsuB
MRTSVATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLFQPFRDFEGVEEEEFQKNLHRLEAKFQLMNRLGIEMILLCSNVGTATINDDDLFVEQLRRAGDLAAKYNVKIAYEALAWGKFVNDFEHAHAIVEKVNHDCVGTCLDTFHILSRGWATDAVENIPAEKIFFVQLADAPKLAMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEIFNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNPEDRPSALELQALPEVAEPAGVDFLEIATGRLGETIRVLHQLGFRLGGHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDTPDPEAAHARAELLRAKTIDRPHIDGEVDLKGVYAPDGVELFFAGPSPDGFPEWLPEFGVDKQETGLINGIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPNDAVRLLLSVAPEDGEQGDFLNAAYPEHIALATDDIVAVAQRARKRGLDFLPVPENYYDDVQARFDLPEEFLDTLKENNLLYDRDEHGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPVRLAAQYREVRDLERGIPS
>NZ_AP017369.1|WP_096454174.1|605180_606602_+|MHS-family-MFS-transporter
MSEQLQGVTHSETTPGKTPKRAALSSWIGSALEYYDFAVYGTAAALVLNHLFFPADTSPGIAILAAMGTVGVAYVVRPLGALIMGPLGDRYGRKFVLMLCLFLIGASTFAVGSLPTFEQAGYLAPALLVLCRVIQGLSASGEQSSAISVSLEHADEHRRALTASWTLHGTQFGTLLATAVFIPFTLFLSEDALMSWGWRVPFWLSAVVVLVAFLIRRGLQEPPAFRENKEAVAGGPSPLAMTLRYHKAAVARVAVAAMINSVNVVFTVWALSFATNIVGLDRSTVLLVPVVANLVALIAIPLSGMLADRIGRRPVFIIGAVGAGLAMNGYLGAIYAGNWTMIFFMGVLMSGLLYSMGNAVWPSFYAEMFPTSVRVTGLALGTQIGFAVSGGFVPVIASALAGEQGDQWVKVAIFVGVTCVISALVAMTAKETKSLTLDEIDALHTARSEAADLAAGAAATTAQTVQKEKEALH
>NZ_AP017369.1|WP_096454172.1|604022_604907_-|LysR-family-transcriptional-regulator
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKAGEILHEEALRTLSRMQSVVDEIQSGEHLITSIKIGVPPGIPIDWLRTQLIDLGPEIRISLIESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHKQELGIVIRCDSELHQQLVGRDNATLFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVKADVALTTEESARTNFPSWRWVPLEAEDASGNDLIVRTWITWNPQPSPAVRDLIQKFIDAI
>NZ_AP017369.1|WP_096459636.1|603060_603333_+|hypothetical-protein
MRIPRKAIRKIEVVDNIIDSVDHPIKRAGRLRIPGVFVAGTHAHVNETEFSMCRKNAPGLVIELENISINRIVISTPHAHRYADELMVVA
>NZ_AP017369.1|WP_096454170.1|601935_602844_+|hydroxymethylbilane-synthase
MTLKIGTRGSKLATTQAGTIRDQLKYFGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDVLHAGECDVAVHSMKDLPTAADPRFHLVVPTRADSREALIARDGLTLAQLPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDADVIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAHATLGGYSGDTMTLTAGVFALDGSDQLVFTAEGDGARPEELGELVAQQLIDAGAPDLLGERS
>NZ_AP017369.1|WP_096454168.1|600539_601934_+|glutamyl-tRNA-reductase
MVSVLIVGMSHRSAPVALLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEVSGVDIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQVANECGSVGPALHSLTQTALHTGKRVHTETAIDDAGASMVSFAVDRALVQMGLDPEAEAPLAGKTALVLGAGAMSSLAATHLGRAGISSLIMANRTLERAERLAQHSMEAGVPAHVVDYDQRASVYGDVDVIISATGAGEFTVKPADIPAGSELMLIDLSMPRDIDDACADLPGVDLVNIERLHKVSREGGAGVTPSEQEALKIVREELDSFTSEQRIRDIVPAVSALRKQAASVGSDELDRLRMRTPGISDTEWVEVEKTVRRVVDKLLHEPTVRVKELAARSGSISYESALQELFGLDAPASTAAPATTAVNASELPDAGIVAVVNAPSATQTRE
>NZ_AP017369.1|WP_167382006.1|600217_600454_+|glutaredoxin-family-protein
MGHSVEIIVRDNCGSCTRVKAQILPVVEAAGIKLTERNVDQDASLKLEFGDRVPVILVDDEEFACWEVDNDELANALL
>NZ_AP017369.1|WP_096454184.1|610528_611569_-|ABC-transporter-ATP-binding-protein
MSSINLRDLSVRFRDGSFGLRDINLEINPEEFVVLIGPSGSGKTTMLRTLAGFVQPSSGNVYIGGQNMTHVPPERRGMGMVFQQHAVWPHMSVAKNVGYPLARKGEKGASISKRVERTLALVGLEGFGRRKPASLSGGQRQRVALARAIIADPTVLLLDEALSALDEPLRDALRRELVSLTRREGLTTVHVTHDRAEAISIADRIVMLGDGRIHQVATPAELLSAPATADVARFIADATVLSGTIKGGKVVCAELDLSWDLSAVQAIDEVAEGDGVDIAIPPQSLSIGGSSVHAEITSVLFQVTSYSVTATTQSGHNFRLSISGQVPKIGETIQLMVRNPLVYRAF
>NZ_AP017369.1|WP_167382007.1|611569_613177_-|iron-ABC-transporter-permease
MQLTQPALSLMRLGVWLIVAGVFITPLALVVGLALGGNQLPTLLDSGLGQALWNSTYTTFLSALGATVVGTLMALTLDRTNVFGRTALRLFLLSPLLIPPFIGAIAWLQLFGRNQGINRFFGTDVWDIYGADGVTFLLIVHSYPTVYIIVSAALRQLPGDLEQAARISGAHTFTVLRTITVPLLKPALLSAFTLTAVANLADFGIPALLGSPARFETLATMIYRFMESGTVSNPLQVVSTIGIVLLFLGIAAVTADYVVSLYASSKLQDAGQSYRFELKQSRIPVSALTWIIALVITAAPLLGLAYRALLPAPGVPFTLNTITLNNFAAALNNPRVIEGFSNSLMLSLGAALICGVLGWLIGVLITRTTHFANVPLTLLVLLPTALPGMIIGVGWLILGRYTDLYNTPWVILGAYVCAFTALVVQAVRGPLSQAPEAIEEAARISGAGRLKSIMDTTAAMAIPAAFAGAVLVAVTAVRELTVSILLIAPGTTTLGVQVFNLQQAGNYNQASALSLMFAILGIVALTLTVRSQKEF
>NZ_AP017369.1|WP_096454186.1|613184_614261_-|ABC-transporter-substrate-binding-protein
MSLKQTLKRTATTVLALGASAALLVACSEPSADTSADATGNASADSTGDATGDAITITAYTSEPEEKVDEINRAFMMANPDIKVEVYRAGTGDLTARIEAEKASGSVEADVLWAADAATFESYAAQGDLAELSDVDTSSVIDEALDAENFYVGTRIIPTVIAYNTEAIDQAELPTSWADLTDPKYAGQLVMPDPAVSGAAAFNASVWKNDPALGEDWITALGENQPMIAQSNGPASQEIAGGGHPVGIVVDYLVRDLAAAGSPIDTIYASEGSPYITEPAGVFADSDKKEAAQRYINFLLSAEGQEIAIEQAYLPVREDVGTPEGTPELADIELMTPDLEVVTADKAAAVEFFQNAMN
>NZ_AP017369.1|WP_096454188.1|614958_616743_+|bifunctional-uroporphyrinogen-III-C-methyltransferase/uroporphyrinogen-III-synthase
MTIAHKPETAETTGIETNQVSETIGVESLTHGNLRSVSSTEGQTEELLPGKVIFVGAGPGNPDLLTVRAREVLGNTVRTITDEQVLEGVRAFVATEIPVPEDKLQAAEDEYERICIEAKENGARRKPARPAPPTAAEITEVADATPAQIVELVQEALAHGGDVIRLVTGNPLSSDTTLAEISAVSEAGMEFQVVPGMSLPATVPAFAGIALGSTYTETDVNGQDLDWDQLASAPQPLVLQARMQDLSRIAEELKARNMPADTPVSVTANGTTRLQRTYDTTLGLLHKLDAELNGPLVVTLGKGVDDRSKYSWWENRALYGWRVLVPRAKEQAASMSERLSSHGAIPQEVPTISVEPPRNPAQMERAIKGIVEGRYQWVVLTSVNAVKAVWEKITEFGLDSRSFAGVRIAAVGEKTAAEIRALGITPELLPARTRQNAQGLVDVFPEYFEELDPVGRVLLPRADIATDVLVDGLTNLGWEVEDVVAYRTVRAAPPSADIRDMIKTGGFDAVAFTSSSTVKNLVGIAGKPHQRTIVACIGPMTAATAEELGLRVDVMPEIAEVPELIDALAEHVADLRAKGELPPPRKKRRRRKAS
>NZ_AP017369.1|WP_167382008.1|616768_617194_+|DUF3806-domain-containing-protein
MDIQQLDAETTAWKDSLLRTAQEAGFHFEPPKLYEDFETMVEQYKQAAAEDPNIDVTDIQQMWGIVVGEYLREKMGMDWVIITDDYGTDLAILATAPNGNHVYSCPIIVVGKRFSPEYEPGQLEFFCNQFMATSLAQLQGK
>NZ_AP017369.1|WP_096454192.1|617272_618292_+|porphobilinogen-synthase
MSTSSEYSHALIRRPRRLRSNPAMRELVAETALRPADLILPMFFADGITEAREISSMPGVYQHTQDSLLRAAHEALDAGVRCIDLFGVPVDADKDFNGSQAWSETGVLNRALALLRKEFGDDLLIMADTCLDEFTDHGHCGVVTKDRRGNAVVDNDATLPLYQQMAVAQARAGAHIVSPSGMMDGQIAAIRAALDEEGFQDVAIMAYSAKYASAFFGPFREAVGSSLQGDRRTYQQDPANLRESLLEAELDIAEGADFIMVKPALPYLDVLTRIADTSPVPVAAYQVSGEYAMIQAAGRNGWVDLDAVMMESLTSIKRAGADQILTYFAVDAARALRNA
>NZ_AP017369.1|WP_096454194.1|618322_618907_+|hypothetical-protein
MSMLPNLSPKKSSPAPSASSQGGNANKKEDTVKLLLQMWALMIGLELVHQILNVVMSFLDPTSLRAVAKEQAESQGLSDSIVNATVVVAILVMGFFNLIVVAILSWMIVMVKNRSKRLPTAFLLLTIFSIFFILRVLMLFFSSPGGTDVPMALFAIDGCVQILVGVSAGVAYALSRTEQPVKMLSEYAPDDAKR
>NZ_AP017369.1|WP_096454196.1|618942_619455_+|hypothetical-protein
MPSMFPSPATGGDDINRRPLNEPQADEHTIPTVLKVVFWMLFATAAFMIFSGLVMYTAGYTGPEDVEESYKDVVVNNQKFIGGINAFAGIVIAALTSQLPRGGKNPRRILLGIVLLVVLTDLLSFATRAGGFALAVIAVLLALEALLMFRPSINAHIERNHMARVMGRKS
>NZ_AP017369.1|WP_096454198.1|619527_622164_+|cation-translocating-P-type-ATPase
MSTPDSSSVDKAVDTAITDAKTAALKAGVGLNRPETSEEEEDFDSGIKISLAFELEGLSNAPSLMAVEKALEHIPGVSADLIYPSQTAWITATDRVHPDTLVDVFAQFGIKAHLSNSSLLRRHQQLSAEVNREARIDRYRSRMASKRTSPRVRRHNREEMMHAVRARESGWFNRKRHMPSQPEDPLSGDVLFTARALITPMRLWVSLPFALIVVTLSLNPTWQFDYWQWLSAVLSIPVVVWGAWPFHRAAAGGIRRGISALDATSSVAIVSAYLWSIAMLLFETPGHKEWRSHPAWFAFDHGTLTKNEIYFDVACGITVLLLAGRLLTRRRSESSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPASTTIPVDGTVIGGGTRIAASIIMGQDQRDVKVNDKVYAGSFNIESEIKVRVIRTGHRTRIAALHRWVKEATLRENRHNRAAIRSAGNLVPITFTLAVVDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRLGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEEGAFLATIELPIFKPSGEKVMRSVEAMLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLNDHVRADASDAIVAIEEQGIETMMLSRDTYPVARRYADSLGITHVLAGIAPGKKPQVVRAVHTRGSTVAMIGDGSVLDSLKVADVGVLMGVDRPSELRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGIAMVFAVSGLLHPMAATVAMLASSLLIEWRSGRARRF
>NZ_AP017369.1|WP_167382009.1|622286_623363_+|uroporphyrinogen-decarboxylase
MSALTVPAARRTLINAPILDATLGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAAILFSDIVVPLRAAGVGVEIVAGRGPVLEAPVRSREDVANLPILEGGIPEVEQGIGIILEELSDSQALIGFAGAPFTLASYLVEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTAILNEIAQYQLPRIHFGVGTGEILGAMSKAGSEVMGVDWRVPLDKAAQRIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEAQTAIDAGHATGHIFNLGHGVLPNTVAEDITEAVAIIHS

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Crispr_ID: NZ_AP017369_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_7

631528-631635

Orphan

Consensus_repeat	Method
AAATCTTGGCACACCTGTTTGGTTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_AP017369_7

>merge|NZ_AP017369|7|631528-631635|CRISPRCasFinder
AAATCTTGGCACACCTGTTTGGTTTGTTCTTGGTTTGTTCTGAGCTAAACCAAACTCAGATGACAAAATTTGCGAAAAATTGAAAATCTTGGCACACCAGTTTGGTTT

>NZ_AP017369|7|7|631528-631635|CRISPRCasFinder
AAATCTTGGCACACCTGTTTGGTTT	GTTCTTGGTTTGTTCTGAGCTAAACCAAACTCAGATGACAAAATTTGCGAAAAATTGA
AAATCTTGGCACACCAGTTTGGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096454222.1\|636725_637079_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_AP017369.1\|WP_096454198.1\|619527_622164_+\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_AP017369.1\|WP_167382009.1\|622286_623363_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_AP017369.1\|WP_096454224.1\|637168_637474_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_167382159.1\|629934_630933_+\|c-type-cytochrome-biogenesis-protein-CcsB	unknown	unknown	gnl\|CDD\|274447
NZ_AP017369.1\|WP_096454212.1\|628248_629874_+\|cytochrome-c-biogenesis-protein	unknown	unknown	gnl\|CDD\|224252
NZ_AP017369.1\|WP_096454228.1\|639014_639881_+\|glycosyltransferase	unknown	unknown	unknown
NZ_AP017369.1\|WP_096454208.1\|626784_627408_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_AP017369.1\|WP_096454202.1\|623378_624761_+\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NZ_AP017369.1\|WP_167382012.1\|634602_636249_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238514
NZ_AP017369.1\|WP_096454226.1\|637939_638836_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695
NZ_AP017369.1\|WP_096454220.1\|636258_636717_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100006
NZ_AP017369.1\|WP_096454206.1\|626169_626778_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_AP017369.1\|WP_167382011.1\|633789_634569_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NZ_AP017369.1\|WP_096459647.1\|637658_637904_+\|DUF4229-domain-containing-protein	unknown	unknown	gnl\|CDD\|379415
NZ_AP017369.1\|WP_096454218.1\|632744_633782_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NZ_AP017369.1\|WP_096454216.1\|631906_632710_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_AP017369.1\|WP_096454210.1\|627408_628215_+\|cytochrome-c-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|223856
NZ_AP017369.1\|WP_096454196.1\|618942_619455_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_167382010.1\|624859_626173_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096454222.1\|636725_637079_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	7.42317e-15
NZ_AP017369.1\|WP_167382009.1\|622286_623363_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	6.39239e-178
NZ_AP017369.1\|WP_167382159.1\|629934_630933_+\|c-type-cytochrome-biogenesis-protein-CcsB	gnl\|CDD\|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	3.7297e-89
NZ_AP017369.1\|WP_096454212.1\|628248_629874_+\|cytochrome-c-biogenesis-protein	gnl\|CDD\|224252	COG1333, ResB, ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP017369.1\|WP_096454218.1\|632744_633782_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	2.21971e-35
NZ_AP017369.1\|WP_096454202.1\|623378_624761_+\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	8.6334e-179
NZ_AP017369.1\|WP_167382012.1\|634602_636249_+\|M24-family-metallopeptidase	gnl\|CDD\|238514	cd01066, APP_MetAP, A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.	1.12933e-09
NZ_AP017369.1\|WP_096454226.1\|637939_638836_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	3.51245e-123
NZ_AP017369.1\|WP_096454220.1\|636258_636717_+\|RidA-family-protein	gnl\|CDD\|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	7.56826e-63
NZ_AP017369.1\|WP_096454206.1\|626169_626778_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	5.50601e-38
NZ_AP017369.1\|WP_167382011.1\|633789_634569_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	9.91007e-112
NZ_AP017369.1\|WP_096459647.1\|637658_637904_+\|DUF4229-domain-containing-protein	gnl\|CDD\|379415	pfam14012, DUF4229, Protein of unknown function (DUF4229). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	4.47401e-15
NZ_AP017369.1\|WP_096454208.1\|626784_627408_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.30114e-28
NZ_AP017369.1\|WP_096454216.1\|631906_632710_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.5057e-58
NZ_AP017369.1\|WP_096454210.1\|627408_628215_+\|cytochrome-c-biogenesis-protein-CcdA	gnl\|CDD\|223856	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones].	6.39265e-39
NZ_AP017369.1\|WP_096454198.1\|619527_622164_+\|cation-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	2.67159e-162
NZ_AP017369.1\|WP_167382010.1\|624859_626173_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0

>NZ_AP017369.1|WP_167382159.1|629934_630933_+|c-type-cytochrome-biogenesis-protein-CcsB
MPVNQTYAQFSDTAFVSAYIIYVLALILSLVYYVKQQGIIDAHREQKRVSELVGTGGSADLPDDIADGVLADDDLTQREESARKLANMTQSLMWLGVMVHLVSVVMRALSASRFPFGNLYEYILVVTLFAMIGAVLILQRPQFRVIWPWILTPMLALLFYGGTQLYSDAAPVVPALQSFWFPIHVSSVSIGASIGIVSGIASLLYLLRMWQPKGKEHGFFGAVAKPLPSGKTLDNLAYKTAIWTVPIFGLGIILGAIWAEAAWGRFWGWDPKETVSFITWVLYAGYLHARATAGWRNTNAAWINILALATMIFNLFFINMVVSGLHSYAGLN
>NZ_AP017369.1|WP_096454212.1|628248_629874_+|cytochrome-c-biogenesis-protein
MLKTVKLYARKAWNWLTSMRTALALLFLLAIAAIPGALLPQRSLNESNVIEYIENNGKLAEFYDKIQLFDVFSSTWFTAIYMLLLISLVGCILPRSWEHYKAMRAPVVRAPRNLARLAHSGEGVVEKREEDVEKDVRKLLKGWKITEYSAEEDRAGVRSISAEKGYIREFFNLVFHLGIVGMIVTAGLGRLFYYEGHVIVVTDGDQNQQNSVFCNTATANYDSFRAGANFDGTGLTTFCFEAHDFSADYLANGQAEMFRSNISYAVGDDIQNDPETWEDYELRVNHPLRIEGDRVYLQGHGFAPTFTVTWPNGETRTQTVQWRPDDPTYFLSSGVVRFDPPAGMYPDLYERRQNQLAIQGLFAPTAQWEGENNELLTSSYPAMRDPAVAIDIYRGDNGLDTGIGQSLFSLDSSLMHSGVLQKIERVNLQVGDTVTLDDGTTVSFDGASEFANYQISRDPTQNWVLVTTVISLVSLVGSLMVRRRRIWVRLYPQENGTTRVETGGLARTDRAGWGSEYDKFHRDLLGLKEDDEDEEYFDHSD
>NZ_AP017369.1|WP_096454210.1|627408_628215_+|cytochrome-c-biogenesis-protein-CcdA
MSEIVVAQSIGQQFADVAASGPLLLGILAAALAGLVSFASPCVVPLVPGYISYLAGVVGGEVEYSAQGTKVKTKRFAVGGAALMFILGFTVVFVLATVSVFGAISVLTLNADTLMRIGGVVTIIMGIVFMGFIPGLQKDTRMAPKRWTTWLGAPLLGGVFALGWTPCLGPTLAAIISISAGTEGMTAARGVILIVGYCLGLGLPFLLIALGSSKALTGVNWLRKHSRTLQIIGGVLLILVGVALLSGSWAIFINWVRQWTVEYGATLL
>NZ_AP017369.1|WP_096454208.1|626784_627408_+|TlpA-family-protein-disulfide-reductase
MRLTKLAATIGCVTLSGLALVACSSDNTAGTDAVAVGGTFQFHSPDGKMEIFYDEADRQQLPDIGGDSLMDEGTEINLSDFENQVVVLNAWGQWCAPCRSESDDLQIIHEELQAAGNGDTPGGTVLGINVRDYSREIAQDFVNDNGLDYPSIYDPPFMTAAQLGGVPASVIPTTIVLDKQHRPAAVFLREVTSQDILDVALPLVDEA
>NZ_AP017369.1|WP_096454206.1|626169_626778_+|histidine-phosphatase-family-protein
MTQTIVHLVRHGEVYNPEKILYGRMPGYHLSSRGRSQAARTAASFEGHDVTYLAASPLQRVQETSEPFVKVTGLELITDDDLLEAGNRFEGLRTKGWRSQLWNPVRWPLMINPTLPSWGEHYTDILERMMAAVERARVAAKGHEAILVTHQLPIVCVQRHARGQSLSHNPATRQCDLASVTSLVFQDDQIAQVHYNEPAQEI
>NZ_AP017369.1|WP_167382010.1|624859_626173_+|glutamate-1-semialdehyde-2,1-aminomutase
MTHMTSSNTAQSAKWFEKALKLTPGGVNSPVRAFGSVGGQTRFIDKAHGSTLIDVDGNSYVDLVCSWGPMLMGHAHPEVVEAVQKAVVDGLSFGAPTIGEVELAEEIVKRTSVEEVRLVNSGTEATMSAVRLARGYTQRSKILKFEGCYHGHVDALLASAGSGVATFALPDSPGITGAQTADTIVVPYNDIEAVRNAFAEYPGQIACIIAEAAGGNMGTVAPQDNFNDKLLAIAHADGALLILDEVMTGFRTSYRGWFGVDKVAADLVTFGKVVSGGLPAAAFGGKAEIMNMLAPQGPVYQAGTLSGNPVAVAAGRASLKLADESLYSTINANADRLHGLISDALSKEGVAHHIQRASNMLSIRFAEGEGHNFTDMKAADTFRFAPFFHTLLDNGVYAPPSVFETWFVSSALSDDDFSKIEQALKPAARAAAEAKAS
>NZ_AP017369.1|WP_096454202.1|623378_624761_+|protoporphyrinogen-oxidase
MRFAIIGAGLAGLTAAYEIHKADPSAVIDVLEAGERIGGKLFTVPFASGPTDIGAEAFLAARSDAVEFFTELGLADSLVSPSEAKSQYYAGGKLHEFPAGGVMGIPAEAPTEAPEAPADTDHPFDWTPGQDISVGELVRRQYGDEIVDTVVSSLLGGVYSSTADDLGVRASVPALAAALDQLAEAGEQVTLSAAVKTVQAQREATKGTSETSGTSETRPVFQTFKGGYAELYEALAEQCGADIHLDSFVSAITKNAEGFTIKGGGEGTYDKVILAVPAPTAAVLLRDVAPDAAPHLRAIKLASSAIVGMRFDSSDGLPDNSGVLVAVNEPGITAKAFTFSSKKWPHLESRGGALVRASFGRLGDEASARMDEDLLVDAALDDLLTITGFDGRAAGLSEIFVQRWFGGLPAYGVDHIATVAAARAEIAHVPGIEAIGAWAGGVGVPAVIADAQAAVHRLIK
>NZ_AP017369.1|WP_167382009.1|622286_623363_+|uroporphyrinogen-decarboxylase
MSALTVPAARRTLINAPILDATLGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAAILFSDIVVPLRAAGVGVEIVAGRGPVLEAPVRSREDVANLPILEGGIPEVEQGIGIILEELSDSQALIGFAGAPFTLASYLVEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAMQLFDSWAGFLTERDYTEFVLPYSTAILNEIAQYQLPRIHFGVGTGEILGAMSKAGSEVMGVDWRVPLDKAAQRIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEAQTAIDAGHATGHIFNLGHGVLPNTVAEDITEAVAIIHS
>NZ_AP017369.1|WP_096454198.1|619527_622164_+|cation-translocating-P-type-ATPase
MSTPDSSSVDKAVDTAITDAKTAALKAGVGLNRPETSEEEEDFDSGIKISLAFELEGLSNAPSLMAVEKALEHIPGVSADLIYPSQTAWITATDRVHPDTLVDVFAQFGIKAHLSNSSLLRRHQQLSAEVNREARIDRYRSRMASKRTSPRVRRHNREEMMHAVRARESGWFNRKRHMPSQPEDPLSGDVLFTARALITPMRLWVSLPFALIVVTLSLNPTWQFDYWQWLSAVLSIPVVVWGAWPFHRAAAGGIRRGISALDATSSVAIVSAYLWSIAMLLFETPGHKEWRSHPAWFAFDHGTLTKNEIYFDVACGITVLLLAGRLLTRRRSESSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPASTTIPVDGTVIGGGTRIAASIIMGQDQRDVKVNDKVYAGSFNIESEIKVRVIRTGHRTRIAALHRWVKEATLRENRHNRAAIRSAGNLVPITFTLAVVDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRLGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEEGAFLATIELPIFKPSGEKVMRSVEAMLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLNDHVRADASDAIVAIEEQGIETMMLSRDTYPVARRYADSLGITHVLAGIAPGKKPQVVRAVHTRGSTVAMIGDGSVLDSLKVADVGVLMGVDRPSELRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGIAMVFAVSGLLHPMAATVAMLASSLLIEWRSGRARRF
>NZ_AP017369.1|WP_096454196.1|618942_619455_+|hypothetical-protein
MPSMFPSPATGGDDINRRPLNEPQADEHTIPTVLKVVFWMLFATAAFMIFSGLVMYTAGYTGPEDVEESYKDVVVNNQKFIGGINAFAGIVIAALTSQLPRGGKNPRRILLGIVLLVVLTDLLSFATRAGGFALAVIAVLLALEALLMFRPSINAHIERNHMARVMGRKS
>NZ_AP017369.1|WP_096454216.1|631906_632710_+|ABC-transporter-permease
MTSAATEAVVKKPLIPRSSLVIAIKAIIGITGLFVAWELIVLITNPPRFLLVGPSAAFAELFNRPGYFASNAWVTLQEALAGFVLGTALGVLCGAALHYFPAVRTFLYPALVAIDTIPKVALAPLFIVWFGFGFESKVFVAMAIAFFPLVINTFDGLSSVPHELKELARINKATTWQRLTKIEFIYAVPSIFSGMKISISLAVGGAVVGEFISGSKGLGYVILLANSQVDLASMFAAFIVLAAISLTLFYVVDLAAKRLVPWKTYAK
>NZ_AP017369.1|WP_096454218.1|632744_633782_+|ABC-transporter-substrate-binding-protein
MNKKKIAAFTAALAVTIPLVSSCSSGSSGDSVDIMMDVGYLPKHAPFFAAVAQGFFDEEDLDVSLMPGSGSNNTVTSVETGRVFAGFADFGVTVMNQGRGAEVRQVNLLQARSAYAAVADKASGIESWEDLKGKTVATEGAGAMVSMWPYALNQLGYSESDINVVHASSESKIPGLLAHQWDANLALAVSDAPALAALGIEPVVLNWADIGISLYGNGMVVSNETIENEPEKLERFNRALQKGFLWACENPEQTYKDFNAEVQGYEESTILLALEEQCALNWQSETTTEPFGAMSDEGVQQMIDIAQEYLGMDPSVSITPDQVYTNDFITPITQGTVIAAPTQEK
>NZ_AP017369.1|WP_167382011.1|633789_634569_+|ABC-transporter-ATP-binding-protein
MSTTSAISVKNVGVTFHSRDGAENKVLEGVDFDVAPGEFVSIVGQSGSGKTTLLKTISGLQQATAGEVLVNGKPIAEQVEDIAMVFQAPVLLPWRNNLNNVLLPLEFRGSRTKESMDRAYQLLEMAGLKGKETRYSYELSGGMQQRVAICRALVSNPKLLLMDEPFGALDAMTRDSMNFELQKIWMREKCSVLFVTHSISEAVWLGDRVIIVGDRPGHIVADIKIDIPRPRAKEHRFSDVFSDYVAEIESFIGVTAGIS
>NZ_AP017369.1|WP_167382012.1|634602_636249_+|M24-family-metallopeptidase
MHLSSNPAQLKELFGLDAQKSLLFSAIRLDSHPLVAPIIATIKDQDPILLVRQQEQGNIFSSGVPRDKIRFYAPWVTIDDAPLEGIEAASSLPELIKELADATPVCFSPDIAYAHYLAAQDHVQIAVESLAPKAIDVVEVEKGSVEKRFESWRRAGVEEAKKLIRGIAHLEGLEAELDQVGADSRFELLQEIATQHGLDAIYVASPPNFSEITGLAAADGASVLWSADTQSVFLFLPQGTTAPEGSQPVGSFGSVSEAVAVLIGEDKAVGVEEEFIGTALALSLTEGEIVPIQQELGHWRDVRDHEDLPFQIIAARTSVTTMENTLTWTNKRLERGEEFTELDIYAHYLEELEDYALQFTFDVEPYFTNLHSSNRMLFPGPPVDFPINAETRCIQLDAGVAVKKDGVVLGTSDMARSLPRTAAGQEAYDYFFKVVREGIIGQLRPGVICADVHEATLDYLAPQLPRMIDIGMLGADTDFNTIYRKRNVGHLMGKQESFANELRPGYKHILHHGSYGAAEIPWRYNGVAIGTEDLWYIGKDKTYILSQR
>NZ_AP017369.1|WP_096454220.1|636258_636717_+|RidA-family-protein
MTDFATHLHSLGIELPDLPAPAYSYVPFSRHGDTLYLSGQISRNAAGDILEGRVGEDASIEDGIYAAEVATINLLARIQQAIGLDNVAQILKLNVWVNSTDEFIQQPLVADGASQLLEKVFGEAGKHARTALPTHTLPQGALVELDAVVAIK
>NZ_AP017369.1|WP_096454222.1|636725_637079_-|winged-helix-turn-helix-transcriptional-regulator
MTSVIPSRADSVSEPRFAPLKSVPRRITDIAENASDFYKALGDTTRLEILYLIYTTKNARVSANALARTLKISAPTVTHHMKKLISANLVTREQCGKWAYFSIHAAHVDTVAEIFAR
>NZ_AP017369.1|WP_096454224.1|637168_637474_-|hypothetical-protein
MGRLLLIILVIVAIVLLWKAFKPSTWRRNAGVNQGQAPRQVKGPDDDEEFLWNIEKNRFKRRRAEEAALQEEEERLKRARERYATPEEPKEGPDEKPTEDS
>NZ_AP017369.1|WP_096459647.1|637658_637904_+|DUF4229-domain-containing-protein
MYGLARLLLFGVLTLIIHGLALLISAPVPLVMSAMLALIVAFPLSMLIFSKQRSNATLAVSQWDAQRKAHKEWVRNELADR
>NZ_AP017369.1|WP_096454226.1|637939_638836_-|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MSHTEPQPTSATFSDWIQGARPHTWANAFAPVIAGSGVAAFHGGFVWWKALLALIVAWALIIGVNYANDYSDGIRGTDEDRTGPLRLTGSGLAAPKKVKAAAFISFGVAGIAGTALSLLSAWWLIIIGIICVLGAWFYTGGKNPYGYRGLGEVAVFVFFGLVAVLGTQFTQAGFVSWVGVAAAVGVGSMSAGVNLANNIRDIPTDRESGKITLAVRLGDAGARRLFLALISTPFIMSICLAFVAWPALIAIIVFPLALKAAKPIRAHATGKDLIPVIGATGRSMALWAVLTGLALALS
>NZ_AP017369.1|WP_096454228.1|639014_639881_+|glycosyltransferase
MWVGYAVRQIASVFLTLLRMLPLAVRNRVSRGQIPKTGDVVISLTTHGKRINHVHFTIESIARGHIKAPIVLWLDKQDFDSTWPATMNRLVDRGLQVRCSDGSYGPHTKYWNQFREVHGTGVRVATVDDDMIYPEWFLQRLLFIGDLRMDAVVAYRAHRIELRDEHLLPYVKWSPADTSKASFLHFATGVSGVLYPVTFIDYVVSQGDVFLQTCKRADDVWLHACALRSDHPIRQVYAQPRHFAVVPTTQVGALVVGNTLMGGNDEQIAKVYTDEDVAKLVEASKRED

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Crispr_ID: NZ_AP017369_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_8

2407378-2407472

Orphan

Consensus_repeat	Method
GATCCTGGGTCTCCTGGTTTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_8

>merge|NZ_AP017369|8|2407378-2407472|CRISPRCasFinder
GATCCTGGGTCTCCTGGTTTGGTTTATCGCGCTCGACACCAGACACAGGGACCCAGCATTCGGTTTTTTGACGATTCTGGGTCTCCTGGTTTGGT

>NZ_AP017369|8|8|2407378-2407472|CRISPRCasFinder
GATCCTGGGTCTCCTGGTTTGGT	TTATCGCGCTCGACACCAGACACAGGGACCCAGCATTCGGTTTTTTGAC
GATTCTGGGTCTCCTGGTTTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096460106.1\|2409085_2409895_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|227339
NZ_AP017369.1\|WP_096456964.1\|2399095_2400049_-\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|274872
NZ_AP017369.1\|WP_096460103.1\|2395416_2396304_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187613
NZ_AP017369.1\|WP_167381970.1\|2415226_2415397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096456968.1\|2400739_2401666_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_AP017369.1\|WP_096456982.1\|2407619_2409020_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235118
NZ_AP017369.1\|WP_096456966.1\|2400154_2400736_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096456974.1\|2403591_2405244_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_AP017369.1\|WP_096456979.1\|2406138_2407116_+\|asparaginase	unknown	unknown	gnl\|CDD\|199208
NZ_AP017369.1\|WP_096456994.1\|2417071_2417359_-\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_AP017369.1\|WP_096456962.1\|2396453_2399126_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143509
NZ_AP017369.1\|WP_096456977.1\|2405247_2405838_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096460109.1\|2411040_2411655_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096456997.1\|2417599_2418058_-\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|224712
NZ_AP017369.1\|WP_096456970.1\|2401665_2402247_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|237810
NZ_AP017369.1\|WP_096456991.1\|2415515_2416604_-\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274639
NZ_AP017369.1\|WP_167382183.1\|2402566_2403436_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096456988.1\|2411760_2414925_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NZ_AP017369.1\|WP_096456985.1\|2410030_2411047_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223860
NZ_AP017369.1\|WP_096457000.1\|2418134_2418839_-\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096460106.1\|2409085_2409895_-\|EamA-family-transporter	gnl\|CDD\|227339	COG5006, rhtA, Threonine/homoserine efflux transporter [Amino acid transport and metabolism].	6.99373e-73
NZ_AP017369.1\|WP_096456964.1\|2399095_2400049_-\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|274872	TIGR03945, cysteine_synthase, 2,3-diaminopropionate biosynthesis protein SbnA. Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products].	8.20408e-123
NZ_AP017369.1\|WP_096460103.1\|2395416_2396304_-\|SDR-family-oxidoreductase	gnl\|CDD\|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.6343e-142
NZ_AP017369.1\|WP_096456968.1\|2400739_2401666_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.9692e-110
NZ_AP017369.1\|WP_096456982.1\|2407619_2409020_-\|DNA-polymerase-IV	gnl\|CDD\|235118	PRK03348, PRK03348, DNA polymerase IV; Provisional.	0
NZ_AP017369.1\|WP_096456974.1\|2403591_2405244_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	3.81137e-134
NZ_AP017369.1\|WP_096456979.1\|2406138_2407116_+\|asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	2.34482e-109
NZ_AP017369.1\|WP_096456994.1\|2417071_2417359_-\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	1.74359e-07
NZ_AP017369.1\|WP_096456962.1\|2396453_2399126_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143509	cd06842, PLPDE_III_Y4yA_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA. This subfamily is composed of the hypothetical Rhizobium sp. protein Y4yA and similar uncharacterized bacterial proteins. These proteins are homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. Proteins in this subfamily may function as PLP-dependent decarboxylases.	0
NZ_AP017369.1\|WP_096456997.1\|2417599_2418058_-\|cell-division-protein-SepF	gnl\|CDD\|224712	COG1799, COG1799, Uncharacterized protein conserved in bacteria [Function unknown].	1.35259e-44
NZ_AP017369.1\|WP_096456970.1\|2401665_2402247_-\|signal-peptidase-II	gnl\|CDD\|237810	PRK14764, PRK14764, lipoprotein signal peptidase; Provisional.	3.65499e-45
NZ_AP017369.1\|WP_096456991.1\|2415515_2416604_-\|DivIVA-domain-containing-protein	gnl\|CDD\|274639	TIGR03544, cell_division_initiation_protein_DivIVA, DivIVA domain. This model describes a domain found in Bacillus subtilis cell division initiation protein DivIVA, and homologs, toward the N-terminus. It is also found as a repeated domain in certain other proteins, including family TIGR03543.	1.33449e-10
NZ_AP017369.1\|WP_096456988.1\|2411760_2414925_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_AP017369.1\|WP_096456985.1\|2410030_2411047_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|223860	COG0789, SoxR, Predicted transcriptional regulators [Transcription].	1.69535e-25
NZ_AP017369.1\|WP_096457000.1\|2418134_2418839_-\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	5.6864e-89

>NZ_AP017369.1|WP_096456979.1|2406138_2407116_+|asparaginase
MSKQHSTPSNNDEEHTSPTQKVAVITTGGTIACTSDANGHLLPTVSGAELLAPIAPRFNGAQIAFEIYEINRLDSSSMTFEDLDTIIATVHKVLEDPNVVGVVVTHGTDSMEESAIAVDTFLNDPRPVIFTGAQKPFDHPESDGPNNLFEACLIASDPSARGIGALIVFGHAVIPARGCVKWHTSDELAFASNGPEEPERPDALPVAKLADVSVEIIPAYPGATGTMVEAALAAGAQGLVVEAMGSGNVGSRMGDALGKALDAGIPVVMSTRVPRGEVSGVYGGAGGGATLAAKGVVGSRYFRAGQARILLAAAIATGVHPATLF
>NZ_AP017369.1|WP_096456977.1|2405247_2405838_-|hypothetical-protein
MKLFKATAVTFTVAAALTLSACSSSDDSSSDSSTTASSSASASSDVASQYPTAEELNAILAVATDPEAPIEEKIKTVQGSENAPELFETMTQAKVESGAEFQVVGSVLPGYDPTSEVLTTVMFQLPDRAEQEAEGVEFVNTDGNWQLSQDWACILITNTVAPEQVPPMCVGTDASSAGIEDVPAEEGAVVEEAPVQ
>NZ_AP017369.1|WP_096456974.1|2403591_2405244_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MRTFANYIAIDGLSFSYPNTHVLTDISLTVSKGEIAGLIGENGVGKSTLLSLIAGVIEPDQGTIYLPENTGFIAQETDLPFDQPVQSLIDAAVAPVRAVDAAIAELSTQLSDESLSAEQQAKVATDFDAALGAAEELGLWELDARIETVVAGLGLADVERSTAIGELSGGQRRRFALAALLMEPHEALIFDEPTNHLDDSAVDFLISEISRFKGPILIASHDRFFLDAVCTELIDLDPALGPEGGAGEEVKQAVSFGGGFSEYIKERELRRTRWSQLYLAQETERAKLEDATGMEESDIFHRSTSKSESKITEKFYADRAAKTQGNRVRSAKNRLKELERYEIPAPPKPLEFQGIPDFTRHGHGETLEVRGVAVENRLQPLTFRIDPGDHILVEGPNGVGKSTLLSVLAGTLEPTEGELIIPEGLKIARLKQDDQWTDKQLDTPVDELFATLSKGPVELSLVEMGLLRKASQSSPLRALSLGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELEAAMEKFPGRVILASHDRWIRKRWTGKKISLSF
>NZ_AP017369.1|WP_167382183.1|2402566_2403436_+|hypothetical-protein
MGLAVDAPRVVVLDPGSGNLQRLEYQDISSEGAAASQEQTINIAQGFAQSIGDAASVDTQAPAGGDVTTFHLPVTASTTEAEFSDQETVSASRDISLTVGKPTFTDLTQVEDVNSTEGFTLGVRATDSGQHTTLSFAAPVDATDNGRMLMEQYLLTYTSLPIVFPAEDLGVGARWSVDSRVTGESTLLQTVTYTLNSIEGSTVNLDVEVSQRPSMGALEITDDETSDSAEQLTVLNSNTTSVGNLVVDLKQPLPTAGQVSWTTRVIYGGSNEQVRVVQDTTSSISFGDE
>NZ_AP017369.1|WP_096456970.1|2401665_2402247_-|signal-peptidase-II
MVNVTSKDAGANLTPMRKKEKRTTVKQVVALMAAIVVVIASLDQIVKQIMLNWLEPGVPVPIIGNWFRFYLLFNPGAAFSMGGENSTWIFTCIQLSFVVGIAIYAPRIKHKWVAAGLALVAGGALGNLLDRLFRDPSFFFGHVVDYISVGDFAVFNIADASITCGVVVFLIGMVLEDREAARVAKAAEEKEVA
>NZ_AP017369.1|WP_096456968.1|2400739_2401666_-|RluA-family-pseudouridine-synthase
MNRQSRTLPVPEGLAGMRVDAALSKLLGISRTVAAELATAGDVSVDGAVVGKSDRLVADTMLDVLLPEPAAPLMPKEEIVPGLDILYSDDDVIAVNKPVGVAAHPTVGWEGPTVVGGLAAAGFRISTSGPPERKGIVQRLDVGTSGVMVVAASERGYTVLKRAFRDRTVDKTYHALVQGHPDPLTGTIEAPIGRHPSAGWRFAVTTEGKHAVTHYETLEAFQEATLVKIHLETGRTHQIRVHFSALHHPCCGDPMYGSDPALSKRLGLNRQWLHAVSLGFNHPADGRWMEIESPYPQDLQHALDVLRA
>NZ_AP017369.1|WP_096456966.1|2400154_2400736_-|hypothetical-protein
MDGFDKGRRIVALFAILALIIVVAVLSFSDRTAKPMQLNGDMLGQDSSETSAEYLQRASDSLDRAEDGEKAYSLVTFAQSLPTAEASDLLEGIGRVNAMIMLSAPAMDLPEPIAGETRKDVFDRQIMLVDAQLSGIGNVRAPRELNGVVVWDTPEKVRPLAESPLVYSIETLPPDAAWGSFGIRPVDTSGTSF
>NZ_AP017369.1|WP_096456964.1|2399095_2400049_-|pyridoxal-phosphate-dependent-enzyme
MNSGPFQSTDELIGKTPLVRLGRFNANTTINLWAKMESYNPGGSAKDRTAHAMVLASDLRPGDTVVESSSGNLGIALSREAVLGGWTFHCVVDPRANRNTIAHMKALGTIVHEITEPDYETGDWLVARRKRVAQLCAQMSEAICLDQYSNTAAFQAHEQGTMTEIVEQLGGAPDYLLVAVSTTGTVGGCLGYVAAHGLSTQVIAVDAVGSVLFDGNAGPRHLPGFGAGMVPELSKHLSPHRVFRIDDKTSVEAARKMAKTEAILPGASGGAVLAAMEILCPDIPAGSNVVVILHDDGNKYLDTIYNDEWVEENLCSR
>NZ_AP017369.1|WP_096456962.1|2396453_2399126_-|diaminopimelate-decarboxylase
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTITTQFSDFSQWLQKHNVDSSFPPRRLVGEFLEESWDALLEYVPHGCSLTMHTKHVDTIKPCGKTSERWLVQEQAFDEILLATGHAHDWPGSLSQEDFPESVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEEIRSAKDLSELSTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLKGFDHLAREMERLAFGPPPESFEYLQELVKSGVVDITHLHRGQEPLADLVRELEITVVIDAVIPPPGVVPGTLVHNLVKEGYARIRPGTRGLDVGADGTVKGQQHLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVVRDASTYPNKVHGIPPLPARLEPWAEKLTSDPATCRHLIEEFGSPVNVLHSGSMPRNINELVDAGIEMGVDTRIFFARKANKGLTFVDAVKDAGHGVDVASERELSQVLNRGVPGERIILSAAIKPDRLLTLAIENGVIISVDSRDELDRIAALVGDRVARVAPRVAPDPGVLPPTRFGERATDWGNRLTEVTPGVDIVGLHVHLHGYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAKSFTWKDDPLSNTYPFYQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLIDPLHITSGDAGEEIEAYLVGAYCIEDELILRRRIRFPRGVKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDIDADLDITIR
>NZ_AP017369.1|WP_096460103.1|2395416_2396304_-|SDR-family-oxidoreductase
MISLLNDPRTLFPKVDPPKQRQPEPGLDIKLSPEADIGLSSYQGNGRLKGRKALITGGDSGIGAAVAIAYAREGADVAIAYLPEEQADADRVLQAIEETGQKAFSFPGDLRDPEYCRSLVQETVNALGGLDILVNNASRQVWAPGLTDITDENFDQTLQVNLYGSFRVTKAAIPHLKPGSSIIFTSSIQAYQPSETLLDYAMTKAALNNLSKGLASSLIGDGIRVNSVAPGPFWTPLQPSHGQPQEKIEGFGKQAPIGRAGHPVELAGAYVFLASDEASYVVGETLGVTGGTPTP
>NZ_AP017369.1|WP_096456982.1|2407619_2409020_-|DNA-polymerase-IV
MQRWVLHIDMDAFFASCEQLTRPTLRGRPVLVGGVSGRGVVAGASYEARKFGAKSAMPMHQAKARVGFGAVVVSPRHVVYSAASRRVFQIIEKRAGIVERLSIDEGFMEPEALIGATPEEVRQWAEELRAEIKEATGLPSSVGAGSGKQIAKIGSGRAKPDGVFVVPVDQQHDLLDPLPVGALWGVGPVTGAKLATMGVETIGDLAALTQKEVEISLGTTIGISLWNLARGIDDRPVEPRAEAKQISQEHTYEKDLTTRQQVDAAIIRSAEGAHRRLLKDGRGARTVSVKLRMADFRIESRSYTLSYATDDYETLEATAFRLARYPGEVGPIRLVGVSFSGLEESRQDILFPELDRQIISPPAPDTDYEAGVQSSAVNNSTIEVHSEEVSTIWRATQDVYHPDFGHGWVQGAGHGVVSVRFETRSTTRGRTKSFAMDDPELQPADPLDSLDWADWFAENGEAEQDD
>NZ_AP017369.1|WP_096460106.1|2409085_2409895_-|EamA-family-transporter
MVVNGVSLYAGAALAVGLFESFPPALVAWMRVAAAAAILLVLYRPAVRSFIGQTGFYAAVYGVSTLAMNITFYEAIARIPMGTAVAIEFLGPIAVAALGSKTVRDWAALLLAGIGVLVISGAQWSDNSIGVMFALAAALLWAMYIIAGNRIAGDASSSKTGMAVGFTWAAVLSLPLAIWWWPGLGATELSLIEVIGLALGLGVLSAVIPYGLDQIVLRMAGRSYFALLLAILPISATLMGALALGQMLSVAELVGIVLVVIAVALRRPS
>NZ_AP017369.1|WP_096456985.1|2410030_2411047_-|MerR-family-transcriptional-regulator
MLIGEVSKLSGVSARMLRHYEKLGLVTPEQTASGYREYAESDVRRILHIEGLRSLGLSLKQVGEALDDPEFDPQAVVSEMIAKTSARISMERELLARLKAVRDAQVSDWESALDAVQILHRLRSGDPTQRQAVAFDSVSGREDVAPETLVESALGEADLNAEGALSWAVVQRGEEAVALAARGLRSKDVAVRLRAVRIVSRVIASAPSTGATGQWLRQALHDVDPSVRAEAALALGKARDELAVEQLVSMVLTGVRDVDAAELLAGFDQSVQVEVMGKFERALEDEETMSPVRGRIAQALAEFDIAPARKLIVQLVDDENPTVAYTVAAILKARRWKS
>NZ_AP017369.1|WP_096460109.1|2411040_2411655_-|hypothetical-protein
MNNFEHSNASIRLQAALSAGTTADTSAIDILVQRSGVEQDFFVRDMITWALTRMPAREILDRVVADLDTNPNDRPFGASQALHTLSKLKVADSWQELKARPGLLHRDDTAQTAWRTFVGLVPEEDTAWLAGHLFQELDKGTLEIQRSLSRAMAELEGREASISELLGALTSPHAVATAKLIADPDSDFMADLEEARRVDNMGAC
>NZ_AP017369.1|WP_096456988.1|2411760_2414925_-|isoleucine--tRNA-ligase
MSEAVGGVYPQVDLSGGSSKFPEMEENVLNYWKQDDTFQASIDQREGAEDYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYQTMRGYRVPRVFGWDTHGLPAELEAEKQLGIKDKGEIEAMGLAKFNEYCATSVLQYTKEWEEYVTRQARWVDFENGYKTMDLSYMESVIWAFKELYDKGLIYQGFRVLPYSWAEHTPLSNQETRLDDSYKLRQDPTLTVTFPVTGTVEGTDANPDLVGALALAWTTTPWTLPSNLALAVNPSVTYALVEVAEDGEAEFVGKRVLLAKDLIGAYSKELGAEAVVVSEHPGSGLVGLTYEPIFGYFRDHANAFQILGAEYVTTEDGTGIVHQAPAFGEDDMNTCNAAGIEPVIPVDMDGKFTSLVPEYQGQLVFDANKDIIKDLKAAGRVVRHQTIEHSYPHSWRSGEPLIYMALPSWFVNVTEIRDRMVEVNQDIEWMPAHIRDGQFGKWLEGARDWNISRSRYWGSPIPAWVSDNDEYPRVDVYGSLDELEADFGVRPKSLHRPDIDELTRPNPDDPTGKSTMRRVTDVLDVWFDSGSMPFAQVHYPFENKEWFDTHAPADFIVEYIGQTRGWFYLLHVLSTALFDRPAFKKVVAHGIVLGDDGLKMSKSKGNYPNVNEVFDRDGSDAMRWFLVSSPILRGGNLIVTEKGIREGVRQAQLPMWNAYSFLQLYTSKKATWSVDSTDVLDRYILAKLHDLVADTQAALDSTDIAKACDLVRNFCDALTNWYVRRSRERFWAGDEAHPEAFNTLYTVLETLTRVAAPLLPMTTEVIWRGLTGERSVHLTDFPSADSFPADAELVRTMDEIRGVCSAASSVRKSHKLRNRLPLPGLTVALPDADRLADFASIIRDEVNVKNVELTSDVDAVGTFEVVVNAKVAGPRLGKDVQRVIKAVKSGNYTREGDVVVADGIQLNDGEFTERLVAANPDSTAQIDGVDGLVVLDMNVTEELEAEGWAADAIRGLQDARKNSGFEVSDRISVVISVPEDKKEWITTHADHIAAEVLATSFEITTDALDGETHDIVAGVTAKVTKN
>NZ_AP017369.1|WP_167381970.1|2415226_2415397_-|hypothetical-protein
MTLVFFAALILSFIGFILLVITVIEPSHTWTVLLIVVVVAGLICFGIDMWNKHKAR
>NZ_AP017369.1|WP_096456991.1|2415515_2416604_-|DivIVA-domain-containing-protein
MPLTPADVHNVAFNKPPIGKRGYNEDEVDQFLDLVEDTLVQFQEENDDLKQQVEELEAQIADGSSAAGSSTAGAAVATKSVDEAALRKEIEQKLRSEYASKLDEASKATQKAQNDAKSAQDQLQRAQADAKAARDEAEKAKAEAKNAASSNNTKAAAVGAAGAGAGAAVATGAANVDTHMQAAKVLGLAQEMADRLTSEARSESKSMLDEAREAAEKQIEEANSTSNRTLEEARANAEKQIADAEARANTLVSEADTKAKNLVSEAEKKSAATLAASTSRAEAQIRQAEDKANALQADAERKHTETMAAVKEQQNALETRIAELQTFEREYRTRLKSLLEGQLEELNARGSSAPSSNKPSGE
>NZ_AP017369.1|WP_096456994.1|2417071_2417359_-|YggT-family-protein
MGNIALLIAWIIGIYTWVLVARIVIEMIQSFSRSFAPPKWFYFIAEPIFMVTDPPVKLLRRIIPPLPLGNVRLDLSVLVLFFILSILQQVIRAFA
>NZ_AP017369.1|WP_096456997.1|2417599_2418058_-|cell-division-protein-SepF
MSMLKKTKEFFGLAPYEAEHEDAYYADEPRYEGTAAYAPEYRERDYGYAPEAPAPVAPTPAPRSYQSTIVPVELHSFEDAQVIGAAFRDGDAVVFDMSLLSREEARRIVDFAAGLCFALRGKMQKIDSLTFAVVPELSNISTSELERAARIR
>NZ_AP017369.1|WP_096457000.1|2418134_2418839_-|YggS-family-pyridoxal-phosphate-dependent-enzyme
MERREELQARLQQVQTRIDATLNEFNRAAGSVRLLPVTKFHPVEDIKILHDLGVTAVGENREQEARAKALELPEMDFHMIGQIQSKKANSIARWAAAVHSVDSEKIAEALNRGVGLALERGDRTSKVLPCFIQLSLDGDPSRGGTPLDQVNQLAETISNSLHLRFEGLMCVPPLGWDAENAFSQARDVLSGLEEHFDRSLEFSAGMSGDLVAAIKHGSTIVRVGTEILGNRPLA

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Crispr_ID: NZ_AP017369_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_9

3128210-3128304

Orphan

Consensus_repeat	Method
GACCAAACACAGAGACCCAGCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_9

>merge|NZ_AP017369|9|3128210-3128304|CRISPRCasFinder
GACCAAACACAGAGACCCAGCATTTAAGTTTTTCGGAATCCTGGGTCTCCTGGTTTGGTTTATCGCACTCGATACCAAACACAGAGACCCAGCAT

>NZ_AP017369|9|9|3128210-3128304|CRISPRCasFinder
GACCAAACACAGAGACCCAGCAT	TTAAGTTTTTCGGAATCCTGGGTCTCCTGGTTTGGTTTATCGCACTCGA
TACCAAACACAGAGACCCAGCAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096458588.1\|3121908_3123039_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|237408
NZ_AP017369.1\|WP_096458585.1\|3120307_3120529_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096458629.1\|3139951_3141145_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_AP017369.1\|WP_096458608.1\|3128596_3129793_-\|multidrug-effflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NZ_AP017369.1\|WP_096458614.1\|3132157_3132916_-\|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_AP017369.1\|WP_096458626.1\|3136986_3139452_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|319004
NZ_AP017369.1\|WP_096458623.1\|3135962_3137000_+\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NZ_AP017369.1\|WP_096458597.1\|3124530_3125538_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP017369.1\|WP_167382198.1\|3134486_3135962_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_167382133.1\|3130031_3131342_+\|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl\|CDD\|224202
NZ_AP017369.1\|WP_096460260.1\|3121296_3121851_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|184875
NZ_AP017369.1\|WP_096458602.1\|3126362_3127865_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NZ_AP017369.1\|WP_003853699.1\|3123731_3123944_-\|DUF3263-domain-containing-protein	unknown	unknown	gnl\|CDD\|378688
NZ_AP017369.1\|WP_096458611.1\|3131338_3132157_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_AP017369.1\|WP_167382134.1\|3133872_3134367_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_AP017369.1\|WP_096458600.1\|3125564_3126356_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NZ_AP017369.1\|WP_096458617.1\|3132912_3133842_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_AP017369.1\|WP_096458582.1\|3119720_3120101_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|183613
NZ_AP017369.1\|WP_096458594.1\|3123959_3124541_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|237227
NZ_AP017369.1\|WP_096458591.1\|3123099_3123726_-\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096458582.1\|3119720_3120101_+\|cation:proton-antiporter	gnl\|CDD\|183613	PRK12592, PRK12592, putative monovalent cation/H+ antiporter subunit G; Reviewed.	2.65746e-72
NZ_AP017369.1\|WP_167382133.1\|3130031_3131342_+\|Na/Pi-cotransporter-family-protein	gnl\|CDD\|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	1.08973e-77
NZ_AP017369.1\|WP_096458629.1\|3139951_3141145_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_AP017369.1\|WP_096458608.1\|3128596_3129793_-\|multidrug-effflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.44327e-99
NZ_AP017369.1\|WP_096458626.1\|3136986_3139452_+\|serine/threonine-protein-kinase	gnl\|CDD\|319004	pfam16918, PknG_TPR, Protein kinase G tetratricopeptide repeat. This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).	1.76171e-93
NZ_AP017369.1\|WP_096458597.1\|3124530_3125538_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.30664e-11
NZ_AP017369.1\|WP_096458611.1\|3131338_3132157_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	2.07267e-91
NZ_AP017369.1\|WP_096460260.1\|3121296_3121851_-\|alpha/beta-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	1.15701e-06
NZ_AP017369.1\|WP_096458602.1\|3126362_3127865_+\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	7.37113e-120
NZ_AP017369.1\|WP_003853699.1\|3123731_3123944_-\|DUF3263-domain-containing-protein	gnl\|CDD\|378688	pfam11662, DUF3263, Protein of unknown function (DUF3263). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.49121e-25
NZ_AP017369.1\|WP_096458588.1\|3121908_3123039_-\|glutamate--cysteine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	0
NZ_AP017369.1\|WP_167382134.1\|3133872_3134367_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	5.56203e-15
NZ_AP017369.1\|WP_096458600.1\|3125564_3126356_+\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.17898e-105
NZ_AP017369.1\|WP_096458617.1\|3132912_3133842_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.00819e-93
NZ_AP017369.1\|WP_096458623.1\|3135962_3137000_+\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.26142e-76
NZ_AP017369.1\|WP_096458594.1\|3123959_3124541_+\|peptide-deformylase	gnl\|CDD\|237227	PRK12846, PRK12846, peptide deformylase; Reviewed.	5.53213e-77
NZ_AP017369.1\|WP_096458591.1\|3123099_3123726_-\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	3.16804e-05

>NZ_AP017369.1|WP_096458602.1|3126362_3127865_+|cardiolipin-synthase
MNLQINLESWQTVGLIIDYTIKIIAIGYVPEGRRPSSSTAWLLAILLLPYVGLPLFLLMGSPYINRRRHRIQQEVNDLIEDVHDDVPDVPDGMEVSPEVESVIKLNRRLTRMPAVTGGNCGFYSDYRESLKRMTAAIDEAEEYIHVEIYIMAWDKYTQPFFTALENAHNRGVKVRLLFDHVGSWKYPGYRRLKKELNRMGFAWYLMLPLQPWRLRFRRPDLRNHRKMLIIDGHTGFMGSQNLIAPSYLQRKNIKLGREWKDLMVELSGPIVSSMEMIFAGDWYVESNEALDIRDHAEAHGYIGNTQKDSATNLVQLIPSGPGYTTEPNLRMFNSIVHHAKERLILCSPYFIPDESLLEAVTSACYRGVTVELFVSEQADQFAIDHAQSSYYQALLEAGVRIYQFPKPDVLHTKYMIADPHDTDGNEALAVLGSSNLDIRSFGLNYEISLMIAKGNLIQELNTLTDRYRDASKELTLERWNQRSWRRRYVDNVMRLTSALQ
>NZ_AP017369.1|WP_096458600.1|3125564_3126356_+|exodeoxyribonuclease-III
MRIVNWNVNSARTRVDRMVDFLLRHDVDVLAVQETKCKDEQFPTERFTEIGYEVAHFGLNQWNGVAIISRVGIENVETHFPSQPGFNKDITKEQSIEARAIGARCGGVQVWSLYVPNGREIADPHYDYKLRWLFALRNYVIDTLEYRPDEKLVLLGDFNIAPTDIDVWDIAAFEGKTHVTEPERAAFDGLIEAGLTETTPGPGTYTYWDYKGARFLKGEGMRIDFQLASPALAKTAGDTFVDVEERSGTGASDHAPVIVDYKV
>NZ_AP017369.1|WP_096458597.1|3124530_3125538_+|GNAT-family-N-acetyltransferase
MTPSLPRFRSHKPAIGDRVVARRRIPGASVHWTDVIGHVIGLDPLVVRPQSVGGMPSDAKEIVIPADQLEVIKILSPRTIRNSDIRAVEVATAKAFPGLVNEWHDGWLLRAGDGIAERSNSASPLGPGVGFEPVPMEEISRFYSQHDLPVKVHIPERIGRPAQKMVDADPKQWVMGPEILVMTKSLEHIEAREMVGELEFSVDKQPDQDWLDMYHFRGQALPAHALELLRTQIDGRMGFGRLTTPAGQTVAITRATITAAEERIFLGYSAVEVAPAYRRQGLGTALGSRIQAWGAEQGAEEAYLQVVAHNEAGIGLYEKLGFSEHHRHRYAERKF
>NZ_AP017369.1|WP_096458594.1|3123959_3124541_+|peptide-deformylase
MTVRPIVIHGDPVLHNPTELVTEDVSELQELIADMYETMDVANGVGLAANQIGVSKRIFVYDCPDDEGVMHKGCFINPVLETSEIPETMPADDGSDEEGCLSVPGEGFPTGRAHWAKVTGLNEKGEEVSVEAEGFLARCFQHEVGHLDGFLYTDVLIGRWKRMAKKAIKANGWTEPGLTWMPGEDEDPFGHDA
>NZ_AP017369.1|WP_003853699.1|3123731_3123944_-|DUF3263-domain-containing-protein
MLSADDLTLLEFEAHAPHAIGAKEEAIRATFGISPVRYYQRLNVIIDTPEAMKVNPTLVSRLRRRAGKID
>NZ_AP017369.1|WP_096458591.1|3123099_3123726_-|LytR-C-terminal-domain-containing-protein
MTSDMQNSPQHSATPEEEKQGGLPMRGLAMILIAVAVLLAAWALWSMQGKDDSTSTASSTEQTQSTQTNPGTTGSVAASEPEAGAESSEEAAENASEETAADPQPAGNASTPVNTLYVLNNSTVPQLAARVADTLSGDYQNVESGNLPDTIIPQNTVYFTAGNAEAEKAARELADRVGGVAMERSEVLPTETEGRDAIVLVLVQDVAL
>NZ_AP017369.1|WP_096458588.1|3121908_3123039_-|glutamate--cysteine-ligase
MGIEFKRSPRPTLGVEWEIALVDPTTRDLAPRAAEILEIVGKNHPEVHLEREFLQNTVELVTGVCDTVPQAVAELSHDLDVLKEAADELGLRLWTSGSHPFSDFRENPVSEKGSYDEIIARTQYWGNQMLIWGIHVHVGISHEDRVWPIINALLTNYPHILALSASSPAWDGLDTGYASNRTMLYQQLPTAGLPYQFQSWDEWCSYMADQDKSGVINHTGSMHFDIRPASKWGTIEVRIADSTSNLRELSAIVALTHCLVVHYDRMIDAGEKLPTLQQWHVAENKWRAARYGLDAEIIISTDTDEAMVQDELRRLVSRLTPLARELGCVRELELVLEILERGGGYERQRNVFKKTGDWKAAVDLACDELNDLKALD
>NZ_AP017369.1|WP_096460260.1|3121296_3121851_-|alpha/beta-hydrolase
MPDVFTDVVNELPSGLGLKPRIVPWSGSVSQGVKAVESILDREEIRRVILVGAGTGAGVALTIAQNQPRRVERLVLDSPLVSFDDKQLKSMSTALKIMPGFLFRKKNKKDLLQQVEEARATTPPQFSDVTAPTLIIKGSSKKATIGEDLAIPGAQTSVINGAGWLTFTTHGRQTGAAIAEFLSQ
>NZ_AP017369.1|WP_096458585.1|3120307_3120529_+|hypothetical-protein
MLKIGTIVAILGAIIFIASVVASGVHYRISETAGEVTNTPAWILTWQGVGLVIATIGVIVFLAAIIRENRSQN
>NZ_AP017369.1|WP_096458582.1|3119720_3120101_+|cation:proton-antiporter
MDLQLFTDIVSLVLILSGAFLSFSASIGLVRFKDTMSRVHSMTKPQTTGLILTVVGAIIRILGHEHFDQSQRSDLGVLVLLVLFALLTSPVTAQRVGRVSRREGLYGAKDDMSDNQAPAELKPKKP
>NZ_AP017369.1|WP_096458608.1|3128596_3129793_-|multidrug-effflux-MFS-transporter
MQKKQQLTTALIMGLALLSASSALSTDMYLPAMPGIAEDLNTTAPMVQLTLSSYMAGMAVGQLIIGPLSDQLGRKSLLVAGAVAALVASFVCALAPSISVLIIARLVQGLGGGACVVIARAIVPDLERGQKAAQAFALLMIIQGVAPVVAPLIGGMLVGPFGWRGIFWALALINLAQLLVASFQIKESKPVEERTAAGLMGMLSNYTFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVLQNQMGIPVLLYSVIFGVNACGLIIGGMINRRLLRSVHPHRIMQFVLASFTVLCAVLLIEVLVIHWTPLFLVLLFLLVSHIPMVMANATALGTEVVRSRAGSGSAILGFVQFAMGALVSSLVGLGSDKAVSMAFSMTVCAILACGCAYLAGRKGVPEMK
>NZ_AP017369.1|WP_167382133.1|3130031_3131342_+|Na/Pi-cotransporter-family-protein
MSSGFEYVQHPRRALPPPIPERKGPAAAFLPGTFHPINPKNIAASHDQVLLSGWGKLVRSLLVILSILVIIIGINLILDGVYGFGTFSTTQMYQVAKDPLIGVLIGILATALVQSSTTTTTLTVTAVGTGIVSVPVAIPIILGANIGTTITAMLVAFSYMGERREFKQAFTVAAMHVWFNVLVVMFLFIVEQLFHPFRTISGAIATQITEQTGGSLPTSDVMTKVFEPLIEILGMNGLIGLIDNQSIAAVVCLIVGTLFILFAVRAMSSQIRTITAATVTSIMDKVINPENSPKARILSNFWSFILGILFTLMVTASSVTVASMQPVAVSGVVKQKPLLGVILGANVGTTVTAMFATFAIVNDQGEFAIQAALIHVIVNLTGALMVLCIPQLANAIVHLSEKTARFAARSYSVTVATIGSLYILIPSLALLVYVLL
>NZ_AP017369.1|WP_096458611.1|3131338_3132157_-|PhzF-family-phenazine-biosynthesis-protein
MSRPFYQVDVFSAEPFMGNPLAVIADADDLSDAQMARIARWTNLSETTFLLSATQREADYRVRIFTPTGELPFAGHPTLGTAHVFQELHGSTHSQLIQECAAGLIPVRTGDQLAFQAPPTIKDGPLDDTYIHHACEALGIGAQLVQGHQWVDNGPGWAVIELPSAQHVLDIEPQFNAEVPLKLGVIGAYPKGSPHAFEVRAFAPGIGEDPVTGSLNASIAQWLNRTGRAGDGYIASQGSVLGRAGEIHISVEEETIWVGGAVATVFKGEALF
>NZ_AP017369.1|WP_096458614.1|3132157_3132916_-|ABC-transporter-permease-subunit
MIKTIRSEWTKLTSTKSFWWTTALVLFFSLGYAALTGSLATGDSFASLFLFAGSTVTGLYLLGFVIIMIQATMMFTTEFRFGYQTQTFLATPKRWVVAVAKWLLYLIIAVILTFITVLLCFYLAKALASDAASSTLQVWNDEQALRIMWQYPLAAALLVTFCSGIALLLRQTAGAVALVLMWHFAIENLLSFLPRVGEYVAKYGPFTNFYAFVTNYQTIDPGWSTTSGALYFGAWAVALFVLGIVVLEKKDA
>NZ_AP017369.1|WP_096458617.1|3132912_3133842_-|ABC-transporter-ATP-binding-protein
MINVEGLTKQYGQVRAVNDLSFEVKPGVVTGFLGPNGAGKSTTMRLILGLDNPTAGHATIEGKHYRSLKNPLTKVGALLDAKATHPNRSAANHLKWIAQANGLPTKRVDEVLALVGLTDVAKKNAGGFSLGMGQRLGLAAALLGDPEYLILDEPVNGLDPEGIHWVRTLLQNLAKQGRTVLVSSHLLSEMAQTAEHLIVIGRGQLVADMPMQEFVRAHSASTVVVRAVDAAALVTALNSAGISYTMGLDALGREAFTINDTSSDDIGRLAFDQGIGLLELSETRASLEEAFLETTGEAVQYQAGGFSKE
>NZ_AP017369.1|WP_167382134.1|3133872_3134367_-|NUDIX-hydrolase
MKGDGDGWAAAPNGSAVWGRNGAAGLLLVAGQQMLMQHRAAWTNNGDTWALPGGARDSHESASESALREAYEETGILPDSVEVLDAIVTAGPFPADPTRPELAGQWTYTTVIARTKTGETLPTTANEESLELRWVNIAEVESLPLMPAFAKAWPELKKRLTAES
>NZ_AP017369.1|WP_167382198.1|3134486_3135962_+|hypothetical-protein
MPDPLDNSAVQKSDIAGSTTARLESLEADQLQEDSHDHWLDPLTEKDTSRRSLVNSIVQETFGQPIFVARRIWAFVSTSPGRMTLMTVVISIAIFAAGYAMSMSSDTRQANLDELITNAEPVSYNAHVLYTSLSVADTTASTGFVQAGVEGPVNRVKYHTAIDRAVVAATHTAASADTTDEHMMDLVLEIQRQLPVYTGLVETARTNNRAGNPVSVAYMSEASAMMRNEILPMASELYNLTSRTVSDQQRAATRPQWIPLSGLLAALAMLLVAQWWLMRITRRRINKGFALATVMMMTATLWVSAANWATWQAGTKGFEEAAGPLNSMTTARIYAQQTRTTETLSLVRRQSIQGSSTGFTATINQIKRALDEYETTSQSETEEHQQLITTIRNAIASWTADHDEFTVLLSTGDYNGAVSAVLSSDDEGQTSFDELDTALAELIADSRSSMRSYIQSGLQATQLVSVMVMLLSIASVLALWIGIRPRLQEYL
>NZ_AP017369.1|WP_096458623.1|3135962_3137000_+|glutamate-ABC-transporter-substrate-binding-protein
MLAFRRPLLRITHLGAALLAATLLVSCTPAPVEQADTLTALDPDAGPPLPPDSSLEAPGEKDPVVETKENWPGSLRPDDKTPEERVPSIVNRGRIIVGVDQSQNLLSFRDPVTGELRGFEIELAREISRDIFGDPNRVDFRFVGSADRLRSLDQGDVDIVIRSVAITDERAKLVEFSTPYLQTQTRMLTMESSGISSIADLPGHTICVTEGSTSLQRARTIAPESSILRTRNWSDCLMALQQHQAQVILGDDVILSGIAAQDPYTEILDTALDSQFYGVAATSTTAGTDSSGLIRQVNSTIERIREDRTWWTMFNDWFGPYLWSYGPPQLQYMPEEEGADNNEGQ
>NZ_AP017369.1|WP_096458626.1|3136986_3139452_+|serine/threonine-protein-kinase
MKDNEDFDPDSPATEAVAFNPFDDDEDDSPATSAVAFNPFEDDDDDEDFHGDGLEFLLRDLDNLRATQGQKVAEPPAEEETTGAVAAHTETTAASIRPRPEVDPSERSRRQAISLFRERRRIRRQSRPVADGMVELPFITPKPEDELLIDPDEKRKPGVQPPQLVAGDIVAEQYEVLGVIAHGGMGWIYLANDRNVSGRIVVLKGMMAQSSIQDQGTAEAEREFLADITHPGIVKAYNFIDDPRVPGGFIVMEYVNGPSLKDRCKAQPDGVLRVDLAIGYILELLPAMDYLHQRGVVYNDLKPENVIATEDQVKLIDLGAVTGIGAFGYIYGTKGFQAPEVATHGPSIASDIFTIGRTLAALTMPLSVEDGILAPGIPSPKHSPLLRRHLSFYRLLQRATAEDPTQRFRNVSELRTQLYGVLREILAVRDGKQYPHQHSLFSPQRSTFGTKHLVFRTDRIIDGIERQARITAPEIVSALPVPLIDRTDPGARMLSGSSYAEPSETLETLRNAMEDEQYSASIEIPLGVVRALLDLGFTTEARQWLETLEERIGDDWRHKWFSGITYLLLDDYATAQVFFNTVLTILPGEAAPKLALAAVDELILQQMGAESTPFLTPEIVSATATLSKDFEELDASAFAALSDTWSHISNDPQVVRFHSLRLYALVWATNPTTVSSAFGLARQLMAENQIELAVQSLDKLSQSSTHYRMATLTTILLLVSSNLSESRIRRAARRLSEIPTNEPRFNQIKIAIMSAGLTWLRERHLQASASANPLFEFPFSQKGLRTGISEALRIQARSAPFAHHRYALVDMANAVRPLTWF
>NZ_AP017369.1|WP_096458629.1|3139951_3141145_-|acetate-kinase
MSLALVLNSGSSSIKFQLVNPENSAIDEPFVSGLVEQIGEPNGRIVLKVEGEKYTLETPIADHSEGLNLAFDLMDQHNCGPSQLEITAVGHRVVHGGILFSAPELITDEIVEMIRDLIPLAPLHNPANVDGIEVARKILPDVPHVAVFDTGFFHSLPPAAALYAINKDVAAEHGIRRYGFHGTSHEFVSKRVVEILEKPAEEVNTITFHLGNGASMAAVQGGRAVDTSMGMTPLAGLVMGTRSGDIDPGIVFHLSRTAGMSIDEIDNLLNKKSGVKGLSGVNDFRELREMIENNDQDAWSAYNIYIHQLRRYLGSYMVALGRVDTIVFTAGVGENAQFVREDALAGLEMYGIEIDPERNALPNDGPRLISTDESKVKVFVIPTNEELAIARYAVKFA

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Crispr_ID: NZ_AP017369_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_10

3263815-3263910

Orphan

Consensus_repeat	Method
AAGACCAAACACAGAGACCCAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_10

>merge|NZ_AP017369|10|3263815-3263910|CRISPRCasFinder
AAGACCAAACACAGAGACCCAGAAATCACATTTTCGACGTTTGTGGGTCTCCTAGTTTGGTGTATCGCTCTCAATACCAAACACAGAGACCCAGAA

>NZ_AP017369|10|10|3263815-3263910|CRISPRCasFinder
AAGACCAAACACAGAGACCCAGAA	ATCACATTTTCGACGTTTGTGGGTCTCCTAGTTTGGTGTATCGCTCTC
AATACCAAACACAGAGACCCAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_167382140.1\|3265324_3265894_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096458924.1\|3270582_3271350_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|223298
NZ_AP017369.1\|WP_096458891.1\|3255061_3258187_+\|DUF3367-domain-containing-protein	unknown	unknown	gnl\|CDD\|378735
NZ_AP017369.1\|WP_096458933.1\|3274366_3275452_+\|UPF0104-family-protein	unknown	unknown	gnl\|CDD\|223469
NZ_AP017369.1\|WP_096458915.1\|3265894_3266704_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_AP017369.1\|WP_096458887.1\|3254880_3255084_+\|DUF2613-domain-containing-protein	unknown	unknown	gnl\|CDD\|378543
NZ_AP017369.1\|WP_096458921.1\|3269509_3270583_+\|TDT-family-transporter	unknown	unknown	gnl\|CDD\|187760
NZ_AP017369.1\|WP_096458936.1\|3275448_3275814_+\|DUF3054-domain-containing-protein	unknown	unknown	gnl\|CDD\|378616
NZ_AP017369.1\|WP_096458903.1\|3261537_3262356_+\|DUF3068-domain-containing-protein	unknown	unknown	gnl\|CDD\|371444
NZ_AP017369.1\|WP_096458894.1\|3258547_3259687_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_AP017369.1\|WP_096458927.1\|3271349_3272036_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|376672
NZ_AP017369.1\|WP_096458909.1\|3264174_3265278_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_AP017369.1\|WP_096458930.1\|3272043_3274362_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_AP017369.1\|WP_096458881.1\|3253125_3254292_-\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NZ_AP017369.1\|WP_096458884.1\|3254383_3254857_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_AP017369.1\|WP_096458906.1\|3262361_3263786_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096458878.1\|3251370_3253062_-\|VanW-family-protein	unknown	unknown	gnl\|CDD\|225341
NZ_AP017369.1\|WP_096458918.1\|3266832_3268665_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NZ_AP017369.1\|WP_096458900.1\|3260436_3261495_-\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_AP017369.1\|WP_167382139.1\|3259713_3260181_+\|DUF4411-family-protein	unknown	unknown	gnl\|CDD\|373028

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096458930.1\|3272043_3274362_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.99048e-139
NZ_AP017369.1\|WP_096458924.1\|3270582_3271350_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|223298	COG0220, COG0220, Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only].	2.63412e-86
NZ_AP017369.1\|WP_096458891.1\|3255061_3258187_+\|DUF3367-domain-containing-protein	gnl\|CDD\|378735	pfam11847, DUF3367, Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	0
NZ_AP017369.1\|WP_096458933.1\|3274366_3275452_+\|UPF0104-family-protein	gnl\|CDD\|223469	COG0392, COG0392, Predicted integral membrane protein [Function unknown].	7.65192e-33
NZ_AP017369.1\|WP_096458915.1\|3265894_3266704_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.54388e-16
NZ_AP017369.1\|WP_096458887.1\|3254880_3255084_+\|DUF2613-domain-containing-protein	gnl\|CDD\|378543	pfam11021, DUF2613, Protein of unknown function (DUF2613). This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	9.19733e-13
NZ_AP017369.1\|WP_096458921.1\|3269509_3270583_+\|TDT-family-transporter	gnl\|CDD\|187760	cd09320, TDT_like_2, The Tellurite-resistance/Dicarboxylate Transporter (TDT) family. The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).	2.59421e-92
NZ_AP017369.1\|WP_096458936.1\|3275448_3275814_+\|DUF3054-domain-containing-protein	gnl\|CDD\|378616	pfam11255, DUF3054, Protein of unknown function (DUF3054). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	3.42929e-19
NZ_AP017369.1\|WP_096458903.1\|3261537_3262356_+\|DUF3068-domain-containing-protein	gnl\|CDD\|371444	pfam11271, DUF3068, Protein of unknown function (DUF3068). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	6.59172e-27
NZ_AP017369.1\|WP_096458894.1\|3258547_3259687_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	1.44674e-16
NZ_AP017369.1\|WP_096458927.1\|3271349_3272036_+\|NYN-domain-containing-protein	gnl\|CDD\|376672	pfam01936, NYN, NYN domain. These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion, unlike the FLAP/5' --> 3' exonuclease superfamily, which binds two metal ions. Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.	0.00023146
NZ_AP017369.1\|WP_096458909.1\|3264174_3265278_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.69988e-52
NZ_AP017369.1\|WP_096458881.1\|3253125_3254292_-\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	4.35021e-73
NZ_AP017369.1\|WP_096458884.1\|3254383_3254857_+\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	3.53241e-22
NZ_AP017369.1\|WP_096458878.1\|3251370_3253062_-\|VanW-family-protein	gnl\|CDD\|225341	COG2720, COG2720, Uncharacterized vancomycin resistance protein [Defense mechanisms].	6.55056e-129
NZ_AP017369.1\|WP_096458918.1\|3266832_3268665_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_AP017369.1\|WP_096458900.1\|3260436_3261495_-\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.7184e-41
NZ_AP017369.1\|WP_167382139.1\|3259713_3260181_+\|DUF4411-family-protein	gnl\|CDD\|373028	pfam14367, DUF4411, Domain of unknown function (DUF4411). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 153 and 170 amino acids in length. There is a single completely conserved residue D that may be functionally important.	5.32734e-29

>NZ_AP017369.1|WP_096458906.1|3262361_3263786_+|hypothetical-protein
MTPTRQIALWAWTTVLLGSLLWPLASAGELLLRDMSVVDHPALSLNALGFGDLPSRNAPQDGVLALLNFLPVSWLVRGMLLGAGFAGAWGAMQLGPSKFLAVTVAIYNPLVVERLLQGHWSLVMAVWLLPLVVALRKHPRWQVVAIWAASLTPTGAVVAGVTGVASSKRKCFTTLFSFLSWLPWLIPALLATPTSGGALTFAIRAETFAGTLGTALGLGGIWNAGAVPASRDAGFAVVGILLFVILLAGFKNCPWVLGLLAVVGMVGAVGPWLLPNLFTWTIAYVPGAALFRDSQKLLMFAVPAYVCLAAGVKHPLSWVATGLALLQIPDAPREVAVMRPSSAHVESVKALAELADDRDTLIIGSTSLATREDGIPVVDPRTKALSVVESGELRVDGIITDAPSQRWTDAMQAWSAGDLERLEQLGIGVVINGDDVIETNAPPQRGWKFYLGVGLTILWMALPLGLLFRRKAKQ
>NZ_AP017369.1|WP_096458903.1|3261537_3262356_+|DUF3068-domain-containing-protein
MKRSAAVLIIVGVLFLIFAFTVPPYVTGQARTIPKDLDLTLVSESPQGFTRSEHIVTSPTDKIDEIATHVESTFTDAQGRTVANITDDVVLIGHSRYPVIKPTASISGSPADSSNAVRTGLHYFFPANTLRNSYPFYDIVLGEDYPLDFVSREDNTYTFYQHLRYLPLDETHKYSVERTLQVDRFSGIIVSKDEALTFHGPDGDDTVEFTYTAETSELLQKNAHDIDQRLSWAKGLDFFSKFFGLLLLAIGVFSTGIFRKGQLMSAVNKLRS
>NZ_AP017369.1|WP_096458900.1|3260436_3261495_-|acyltransferase
MSTQSYAPIRHRGFISSLEGLRAIASLGVLATHVAFQTSVDPATHIGAILARFDFFVAVFFALSAFVLWRRRAGQPVGLYYLKRLARIMPAYWATVIAVLLFIPSGPWLANLTMTQIYWPEGLMTGLTHLWSLCVEVAFYLVIPLLAWILDRFGKPVRLALITGGAALSLVWPWIPLVEHALDEGWANMQIWPPAYMCWFAIGMIAAEIEGIRFPRVPNVVWVVLALVVAWIAGQEWYGPLGLVHPSPWEFNLRILAGTLFAGFLVVPFALGAPSRLLDSAWMKTLGTWSYSIFLWHLPVLTIVFPLLGIPLFSGHFLLVFIVTVALTIPVAAISYTFIEEPIMRWVRRFSS
>NZ_AP017369.1|WP_167382139.1|3259713_3260181_+|DUF4411-family-protein
MTAADSHYPHDVVPGFWTQILDSLATGESKIPESVHKELIAYRAKWVSTWTKTNAAPEFILNEDSAQIQELALITNWVINIRQPPFKISDRNRFLSGADPRIIAVAAVTKSTIVTYEKPAVDPTSRKVKIPDVAAQFGVSCVTPIEMLRGCNRVI
>NZ_AP017369.1|WP_096458894.1|3258547_3259687_+|ImmA/IrrE-family-metallo-endopeptidase
MSVRVPIKPNVLEWAIRKTGAPVEELAQSSDFKNIIEWLTEDKAPTVRQAEKLAAKAGIPYPFLLLNEPVQDEILLPDFRTRGNISITNPSPELEQVINDCTARLDWYVEFARDEDLLPVALIESAHISQSPEQTAIEVRDALGWVPGRYSLGETAVSKLSAAIENTGILVMRSAMVKNNTKRPLDQGEFSGFTLINNGFALIFVNAKDTKSAQLFSLAHELGHVVTGQPGISAEHSPKSELEVERWCNKFAAEFLIPATYFGEIWSEEHSPTDAVSRIAQRVGASPEAVVWRGVELGFIPSGNAQSLIKECSYDGPRKTPDGGNGLNNIRPRIGQRFLAAVSSVIGTDLLSITDAMYYLGTKNRETVRDLMSPREKSA
>NZ_AP017369.1|WP_096458891.1|3255061_3258187_+|DUF3367-domain-containing-protein
MVHAKQTKTPLPRFLHSAHFYVWIALGLLVFAQGPGLVAADTKLDLLLNPAGFLSGALHAWTDTFTLGQLQNQAYGYLFPQGFFFLITDFLPDWIAQRLWWWLVLGVGFSGFYTMLSRLGVSGITGVSGVSGIGTPAFRLIAALLFALSPRTLTTLTAISSETWPIMLAPWVCVPLLSKNINARAIALSLLPAACMGAVNATATMAALIPAALILLYRGLFGRLIVWGIGVLAVNAWWIGPLLVLGKYAPPFTEFIESASVTTSWLNPVEILRGTTSWTPFVDTERQAGYLLVNDALFVFLSVVVAALGLIGLSLMKHRGLWAFMLAVGLLILGSAHLPPVQEFLDGPGAALRNIHKFDLLVRMPLMVGIAALGSHIALPSANTKAANTKAATTKAGLPKRQAAGLLVVLIAAGALAPAWSARLLPQGTWEEVPDYWYEATEFLNENAAGTRTLIWPSAPFARQDWGWTRDEPAQPLLDVPWAVRDAIPLVPPEAIRGLDGVSDLGSRLNDEALKRLGIGAVLVRHDLEADPDIEVDLPGEKYTFGPQGEVDVYLIDPDRDMWITSDTEGPLPTVAGGGEILSLLDTLNGYSPRTLVDGNAQIVTDTPQLVGTNYGDGTSSAALASVAETEVKNRIVDYPSAGPMTQVVQEGSITASSSGSDATSFGGADPDRSLNSLLDHRYNTAWYPTPGDTSPWLEISGTGTTLSISPRETVTATITSGDSVMVREFEKGRTTTVTLAQPHARIEFDSFVGISELSLEGLSRTITVPETSPDVQQFVFQRLTVPTSFLDRTFTVPRPMSVNVDAQSCITLELDGERINCGPLELTPGTHELRTQSEWVTLTESVPHASVQPATTNIEAAPTDRILITTRAFNSGTSMLIDATPLSPIQLDASSQGFIIPAGVSGQLSFTFDGEKPYKLSLFGGATIAVLVVLGCVVVGRRREAMVSWQDTRNAPWAVVALIPVLGWWFIPAVAAWLIVRFTLIPKWVLAGLPLMICGLWLAQAPWPAASYPGDSPALVLLAGVSVAALFAGDLRPPKS
>NZ_AP017369.1|WP_096458887.1|3254880_3255084_+|DUF2613-domain-containing-protein
MAYETDSLNRRTLGPAIASAVVGIAVGAVAVAGVSMISGQDTVPTGNAVTADNALLGGPEYGSREAD
>NZ_AP017369.1|WP_096458884.1|3254383_3254857_+|universal-stress-protein
MTDKTMLVAFDGSPESRRALEYAAQLLQPRKVEILTAWEPLHRQAARAMELSTLGVDPEDPAQSAALETCREGVELAQSLGLEARAHMVESATAIWSAIVDAADELRPDVIVTGTRGIAGWKSLWQSSTADSVLHHADVPVFVVPPLNETEEDETKE
>NZ_AP017369.1|WP_096458881.1|3253125_3254292_-|glycoside-hydrolase-family-3-protein
MWKRLKSVAATVAVAGVLLTGCSEKDSSSLSTPTSTPPAPSQSATPAPSARDLARAQIPDQQREQVASLMMVGVANYDQALDALNQGVGGIFIGSWTDENLLTEPGRNIEALREVVGRDFSVSIDFEGGRVQRATNILGDFPSPRVMAQTMTPEQVEDLAEILGTGLAAHGVTVNFAPVVDVDAWGLPVVGDRSFSNDPAVAATYATAFAKGLSQVGITPVFKHFPGHGRASGDSHTQDVVTPSLDELKTYDLIPYGQALSETDGAVMVGHMIVPGLGTDGVPSSLDPATYQLLRSGDYPGGVPFDGVIYTDDLSGMSSISATHSPAEAVLAALKAGADQALWIDYASLSSAIDLVDAAVTSGEYPQEQMLESALRIQLLYLTRLEQK
>NZ_AP017369.1|WP_096458878.1|3251370_3253062_-|VanW-family-protein
MKNSGKNSAKKRTKGILIGVLVGLFAIFAGVYAVDVFLNKDNIPRGTSVGGVSISNLSATEARTKLETELADDVVQPVTVTAGEQNTSFDPIASGIGIDWDATIEGTGKQSWNPITRFVALFKESEAPIVSTVDPAIFGPTLDRMVGELYRDPVSGSLLIDAGNLVVNDTIDGQAVDRTVLEQAITENWLNPDGVEVEPDVVPAAISQDTIDDLANGAGETAVSGPFTVRGDNDVEGVIPVERMGEVVTFPEENGTIRVDVNAEVATDILSEGLAETETEPTNAQISFSSGSKVVTPEVSGHEINWEQTLADLPNNLTGDGPRTIDAIYEDTPATFTATDAQNATFNEVMGEFTTGGFSAASGINIRLTAQMVNGAVVSPGDTFSLNNYTGPRGSAQGFVDSGIILNGRSDTAVGGGISQFATTLYNAYYFAGLEDITHTPHSYYISRYPAGREATIFDGAIDLQFRNNSPYPVMISTFADDSNVTVRIMGVDTTSVESINNGRWATTQPNTVRVSGSDCVPSTGAPGFTTSDTRIISDLYGNEITRETITTVYDPSPNVVCS
>NZ_AP017369.1|WP_096458909.1|3264174_3265278_-|glycosyltransferase-family-4-protein
MKILLLCWRDTTHPQGGGSERYLERVGEFLAKQGHEVVFRTAGHTDAPRRSFRDGVRYSRSGGKFSVYPKAWVAMMLGSVGIGTFSKVDVVVDTQNGIPFFGKLFSGKPTILLTHHCHKEQWPVVGPVLAQVGWLIESRIAPRAYKKAPYVTVSEPSAQELIALGVNPQQIHIVRNGVDPVPPHIPRLDRDGQHVVTLSRLVPHKQIEHAMDVVAALDGVVLDVVGSGWWQEELVDYAQTLGVSDRVIFHGQVAEDHKHALLERATVHLMPSRKEGWGLAVTEAAQHSVPTIGYRNSGGLRDSIVDGETGLLVDSKAELISATKKLLFDAPLRTHLGTRAKERAENYSWDTAGTQFEELLLGLASKK
>NZ_AP017369.1|WP_167382140.1|3265324_3265894_+|hypothetical-protein
MSTTITVFSPTHSPAQIREIILSAAKEDDVDFLGVPFTHPRNVTIEIDDDLINDCLGWLDDVALASGLGIQYDDEILRYGDEDIAFTTQTKGDDDARIGASRLGLEHLLNSIADDDDYLKIAQFDIENPADESTYISARSLSEVDGWTLEFGVAGVRNTTIVASTDDAITTMLRWMNGEDIRDLNWTRV
>NZ_AP017369.1|WP_096458915.1|3265894_3266704_+|class-I-SAM-dependent-methyltransferase
MVRLSRFPGFLGLPGFLGFPALRRLATLRRSWGLLTDFKFEQTRPDIFYGNLAKDTSNLVEALCEDCVGKGLDGLKVLDVGGGPGYFATAFEQRGSTYFSVEPDVGEMSAAGIDVHGSVRGSGLDLPFQSETFDVVYSSNVAEHVAQPWRMGEEMLRVTNSGGLAILSYTVWLGPFGGHETGLWEHYIGGAFARDRYTKKHGHPPKNVFGESLFNVSCREGLEWGASVADAQLVAAFPRYHPSWAWWMVKVPVLREFAVSNLVLVFRKD
>NZ_AP017369.1|WP_096458918.1|3266832_3268665_-|phosphoenolpyruvate-carboxykinase-(GTP)
MTTAAIKGLQGEAPTKNKELLNWIADAVELFQPESVVFVDGSQAEWDRMAEDLVQAGTLIKLNEEKRPNSYLARSNPSDVARVESRTFICSEKEEDAGPTNNWAPPQAMKDEMSKHYAGSMKGRTMYVVPFCMGPISDPDPKLGVQLTDSAYVVMSMRIMTRMGAEALDKIGENGSFVKCLHSVGAPLEPGQEDVAWPCNDTKYITQFPETKEIWSYGSGYGGNAILAKKCYALRIASVMAREEGWMAEHMLILKLINPEGKAYHIAAAFPSACGKTNLAMITPTIPGWTAQVVGDDIAWLKLREDGLYAVNPENGFFGVAPGTNYASNPIAMKTMEPGNTLFTNVALTDDGDIWWEGMDGDAPAHLIDWKGNDWTPESDEAAAHPNSRYCVAIDQSPAAAPEFNDWKGVKIDAILFGGRRADTVPLVTQTFDWEHGTMVGALLASGQTAASAEAKVGALRHDPMAMLPFIGYNAGEYLQNWIDMGNKGGDKLPSIFLVNWFRRGEDGRFLWPGFGDNSRVLKWVIDRIEGRVGAEETVVGHTAKAEDLDLEGLDTPIEDVKEALSAPAELWANDVEDNAEYLTFLGPRVPAEVHSQFDALKARITAAQA
>NZ_AP017369.1|WP_096458921.1|3269509_3270583_+|TDT-family-transporter
MPKTPSTKNYAAVLPLPGPAWAGSLMGISLLSSLLKTHGFPFAADAFFTLACIVAVVIIGGWLIYRSPRFKTEVMPAWAMLSMGLIALGSASTSVLGDNYWEFMFFCWASGTIIGLVAYSLYTSALLRGTAGTPSFTWGLPLVTPMVASTSAAQLHDHYGSTPLLWISFALFLSTLAVAPLVFARVYFYYFSPHGPRIPLMATPTSWIPLGMVGQSTAAAQLIGDAFTSTTTTRIAIIYGFVMGIISIPLGAIAHFLFYKAVVKGATYSPTWWASTFPVGTLSLGAHFLAQSTELALFDYFSLYLLALMLFHVIVSTIAGTIAVTKRIVEKLNLQSSNDSSKFMHIEVSQLNRKNNK
>NZ_AP017369.1|WP_096458924.1|3270582_3271350_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSISDNSRDQLGELPAGRPLQSDFDNDLDYPRLGSVTFRRGTLTENQQTMWDEKWPELGRILEDELIDLDSWFGRTGAKTIVEIGSGTGTSTAAMAPLEADTNIVAVELYKPGLAKLMGSVVRGDINNVRMVRGDGIEVLNRMFADESLDGIRVYFPDPWPKARHNKRRIIQSGPLNLFAKKLKPGGVLHVATDHADYAEWINELVEVEPLLEYKGWPWAECPQLTDRQVITKFEGKGLEKDHVINEYLWQKVQN
>NZ_AP017369.1|WP_096458927.1|3271349_3272036_+|NYN-domain-containing-protein
MSDVHEVIHSYNPTDKEGPESVLLVWDAPNLDMGLGAILGGRPTAAYRPRFDAIGRWLLARAGRRAHELGRHIEPEATVFANITPGGSDVVRPWVEALRNVGFAVFAKPKVGEDSDVDPDMINHIQRRYEEGVLRGVIVASADGQNFRETLEKLVAEGIPATVIGFHEHASWAVAHETIEFVDLEEIPGVFREPLPRVSLDNLPEGGAWLQPFRPLTALLSNRHNSQE
>NZ_AP017369.1|WP_096458930.1|3272043_3274362_+|MMPL-family-transporter
MFSKWGHFAYRYRRIVPLVVIVAILALFVLFGSKLGERMSQEGWDDPGSSSTAAASIELETFGRDNDGDVVLLFTAPEGTSFDDPEVFDSVSSFLDGLVSNNPDEISQVNSYFDTRNQNLLSADKTQTFAALGLKGDGEQTLKDFRAIEDQLTPDNLAGGVTTEVAGATAVADALDEGMASDIARAEVFALPFVAVLLLIVFGSVVAAAMPLIVGILSILGSLGILAILAGFFQVNVFAQSVVTLLGLGLAIDYGLFMVSRFREEMDKGTPIEQAVATTTATAGKTVVFSAAMVAVALSGLFVFPQAFLKSVAFGAISAVGLAALMSVTVLPSLFGMLGKNIDKWSLRRTARTARRLEDTIWFRVPAWAMRHAKAVTVGVVLLLLALTVPLTGVKFGGINETYLPPANDTRVAQERFDEAFPSFRTEPIKLVVTGADNNQLIDIYVQANEVEGLTDRFTAGATTDDGTTVLSAGIQDRSLNEQVVQQLRDISVPEGVEVHIGGTPAMEIESIEALFEKLPWMAIYIVLATFILMSLVFGSIILPAKAIIMTILGMGATLGILTLMFVDGVGASALNFSPGPLMSPVLVLIMAIIYGLSTDYEVFLVSRMVEARDKGESTDDAIRYGTAHTGSIITAAALIMIVVCGAFGFSEIVMMKYIAFGMIAALILDATIIRMLLVPAVMHLLRDDNWWAPGFVKKAYTVMGHGSDVEEPARPTTRRLNDDEEVTVHEAVVAGDSIASRGGMSTQENRDLVSFVELKARLEKRRLEDLD
>NZ_AP017369.1|WP_096458933.1|3274366_3275452_+|UPF0104-family-protein
MRAIFSNPWIRWALSLAILGVILFFLRDQLEFLKMGIKQIRHISPLGLALTMVALVLSFVAMAKVMQIMLKAGGTTTTLKSTTALTFASNSWSATLPGGPAFSAILTYKVQRSWGASAVLCSWFFLLSSALSTVWLVALGVIAVFFMGASLNLWSLIATLLAMVALSGAVYWAANNPDTLARWVRKIAKNREGGIVEKLLGSIEQLRSVALTGPQFAASAAWSLGNRLFDAFSLWICIWAVTGTAPMFDAEPNNTTIAGVLLAYTTAKIAGSIQATPGGIGPIEAAYIAALVATGMTAIEAAGAVIIYRLCSFIIMAIVGWVIYFIYFTPKGLKANETSEVEQDTINTDSNPQSAIERPET
>NZ_AP017369.1|WP_096458936.1|3275448_3275814_+|DUF3054-domain-containing-protein
MNRWMSLLCDSIAIGLFALFARIAHQSPDMPLNVQGWFFTWLPFLAGVFIAYLAVILPAKLPSEMIRPAGLMVWILAVVVGLVIWGFNNGEVPHWSFMIVATTASAILVLGWRALFKVTMR

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Crispr_ID: NZ_AP017369_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_11

3356312-3356407

Orphan

Consensus_repeat	Method
GCGGAAAATGGTGAATTGACACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_11

>merge|NZ_AP017369|11|3356312-3356407|CRISPRCasFinder
GCGGAAAATGGTGAATTGACACACTTTCAGAGCCAAAAAGCGTGAGGATCCACCATTTTTTAGCAGCAGGTTGCAGAAAATGGTGAATTGACACAC

>NZ_AP017369|11|11|3356312-3356407|CRISPRCasFinder
GCGGAAAATGGTGAATTGACACAC	TTTCAGAGCCAAAAAGCGTGAGGATCCACCATTTTTTAGCAGCAGGTT
GCAGAAAATGGTGAATTGACACAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096459131.1\|3366582_3367422_-\|sortase	unknown	unknown	gnl\|CDD\|226287
NZ_AP017369.1\|WP_096459116.1\|3362870_3363506_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096459104.1\|3355564_3356167_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_AP017369.1\|WP_096459098.1\|3353402_3354626_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349914
NZ_AP017369.1\|WP_096459107.1\|3356919_3357840_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_AP017369.1\|WP_096459125.1\|3365598_3366156_+\|DUF2020-domain-containing-protein	unknown	unknown	gnl\|CDD\|370500
NZ_AP017369.1\|WP_096459095.1\|3352844_3353393_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227231
NZ_AP017369.1\|WP_096459110.1\|3357914_3359147_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_AP017369.1\|WP_096459092.1\|3351717_3352818_+\|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|225635
NZ_AP017369.1\|WP_096459128.1\|3366429_3366582_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096459080.1\|3346945_3347641_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_AP017369.1\|WP_096459122.1\|3364289_3365600_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_AP017369.1\|WP_167382144.1\|3361263_3362775_-\|TM0106-family-RecB-like-putative-nuclease	unknown	unknown	gnl\|CDD\|225160
NZ_AP017369.1\|WP_096459084.1\|3347641_3348430_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|224327
NZ_AP017369.1\|WP_096459087.1\|3349924_3351187_+\|quinone-dependent-L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|376451
NZ_AP017369.1\|WP_096459089.1\|3351394_3351703_+\|plasmid-maintenance-system-killer-protein	unknown	unknown	gnl\|CDD\|226079
NZ_AP017369.1\|WP_096459101.1\|3354677_3355331_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|234604
NZ_AP017369.1\|WP_096459119.1\|3363530_3364169_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP017369.1\|WP_096460326.1\|3348588_3349890_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_AP017369.1\|WP_096460329.1\|3359261_3360809_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379208

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096459131.1\|3366582_3367422_-\|sortase	gnl\|CDD\|226287	COG3764, SrtA, Sortase (surface protein transpeptidase) [Cell envelope biogenesis, outer membrane].	7.06324e-58
NZ_AP017369.1\|WP_096459104.1\|3355564_3356167_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	1.86016e-94
NZ_AP017369.1\|WP_096459098.1\|3353402_3354626_-\|amidohydrolase	gnl\|CDD\|349914	cd05664, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, Uncharacterized subfamily of proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
NZ_AP017369.1\|WP_096459107.1\|3356919_3357840_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.35425e-79
NZ_AP017369.1\|WP_096459125.1\|3365598_3366156_+\|DUF2020-domain-containing-protein	gnl\|CDD\|370500	pfam09449, DUF2020, Domain of unknown function (DUF2020). Protein of unknown function found in bacteria.	3.98396e-87
NZ_AP017369.1\|WP_096459095.1\|3352844_3353393_-\|hypothetical-protein	gnl\|CDD\|227231	COG4894, COG4894, Uncharacterized conserved protein [Function unknown].	9.59465e-60
NZ_AP017369.1\|WP_096459110.1\|3357914_3359147_+\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.54461e-68
NZ_AP017369.1\|WP_096459092.1\|3351717_3352818_+\|HigA-family-addiction-module-antidote-protein	gnl\|CDD\|225635	COG3093, VapI, Plasmid maintenance system antidote protein [General function prediction only].	1.18505e-19
NZ_AP017369.1\|WP_096459080.1\|3346945_3347641_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	7.6801e-44
NZ_AP017369.1\|WP_096459122.1\|3364289_3365600_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.94359e-72
NZ_AP017369.1\|WP_167382144.1\|3361263_3362775_-\|TM0106-family-RecB-like-putative-nuclease	gnl\|CDD\|225160	COG2251, COG2251, Predicted nuclease (RecB family) [General function prediction only].	2.6773e-146
NZ_AP017369.1\|WP_096459084.1\|3347641_3348430_+\|metallophosphoesterase	gnl\|CDD\|224327	COG1409, Icc, Predicted phosphohydrolases [General function prediction only].	9.79294e-21
NZ_AP017369.1\|WP_096459087.1\|3349924_3351187_+\|quinone-dependent-L-lactate-dehydrogenase	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	2.15538e-155
NZ_AP017369.1\|WP_096459089.1\|3351394_3351703_+\|plasmid-maintenance-system-killer-protein	gnl\|CDD\|226079	COG3549, HigB, Plasmid maintenance system killer protein [General function prediction only].	2.43028e-21
NZ_AP017369.1\|WP_096459101.1\|3354677_3355331_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	2.85804e-129
NZ_AP017369.1\|WP_096459119.1\|3363530_3364169_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.74795e-65
NZ_AP017369.1\|WP_096460326.1\|3348588_3349890_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0
NZ_AP017369.1\|WP_096460329.1\|3359261_3360809_+\|hypothetical-protein	gnl\|CDD\|379208	pfam13473, Cupredoxin_1, Cupredoxin-like domain. The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.	1.75373e-07

>NZ_AP017369.1|WP_096459104.1|3355564_3356167_+|superoxide-dismutase
MAVYELPELDYAYDALEPHIAAEIMELHHSKHHATYVAGANAALEALEKAREEGTNPDQIRALSKNLAFNLGGHTNHSVFWKNLSPNGGGEPTGDLAEAINRDFGSFAKFQDHFNSAALGLQGSGWAVLGYDHIAGRLVIEQLTDQQGNISIDITPLLMLDMWEHAFYLQYKNVKADYVKAVWNVFNWDDVAQRYAAASK
>NZ_AP017369.1|WP_096459101.1|3354677_3355331_-|peptide-methionine-(S)-S-oxide-reductase-MsrA
MAWFFTPEPVMVTPDEALKGGKHPVLENPAPHTVLGTPITGPWKDGQKRIWIGLGCFWGVEQMYWKMDGVEGTSVGYAGGFTPNPTYREVCSGRTGHTEIVEVVYDPSKISLEKLVASGLEAHDPTQGFRQGNDVGTQYRSAFYTETEEDAARVKAVVDAYGKTLKQHGFGEITTEIGVISPDQYFLAEDYHQQYLDKNPDGYCPHHSTGIPCGVDA
>NZ_AP017369.1|WP_096459098.1|3353402_3354626_-|amidohydrolase
MTIKALLADLDHTRDYREELYKYFHQHPELSLQEFKTSERIVAELESYGVDSITRIGETGVVAVIENGEGPVVALRGDIDALPMAEESGKEYAATGVTQVDKNTGKETPVAHSCGHDVHISSLLGAVEAFNSHKDAWSGTLMAVFQPAEETAAGARMMVEEGIVDKLPTPDVYLGQHVLGSLPGGAVGTREGAVMSEAASIEITLHGKGSHGSMPNLGVDPIVLGSAIVTRLQSVISREIAASETAVLTVGSFHSGTKSNIIPDSAVLQLNTRAFSKDVSKHLHEAIERIVRHECEAARCPKPPEFKYYDQYPLTNNDESVTERVRAAFDKFFGDNSVDLAQVPASEDFSIIPDAFGVPYSYWGLGGFADWKNAPGNHSPAFAPDIQPTLDRGVEALVVASSAWLIK
>NZ_AP017369.1|WP_096459095.1|3352844_3353393_-|hypothetical-protein
MNPFLNDTLIVQQITSFLSNDFEIYNPEGDVVIRIKTEGSLGSRLVKGDRRFTLEDAFGTPLMQVRDPMNFVRDTYEIDDANGTPIAHVRKRFTFFNKRMDIELPGGSVIEMHGNFLGFDFEFRMGDRIPAHVSRKWSGAAKGFLGRSTYAVNFDAEAPEDIRKVIIGAMIALDLIRAKEQN
>NZ_AP017369.1|WP_096459092.1|3351717_3352818_+|HigA-family-addiction-module-antidote-protein
MNTPIAAELFPVGELLAEELDARGWTQSDFAEVLGRPAQFVSEILSGKKEITRESASQIGAALGTSTELWLNLQDSYFLWKQSQDLKMQENLDAVKTRAQLQDLAPVSLLAKRGFITSTDLEVQKRQVLSLFGKSSFDDPSAIGFAARRSNGDEDFTALQHSWAACVKAVAKELDAAAFSRDLLHDLAKTLSKRMREPKAFAEFQSLFATVGVKLVYIESFPGGKLDGCAMMVDGHPVIGLSGRGKRLDKVLFTLLHEVAHILLGHLRDNGEVILDDLSADHGGKEAEADRLASKLAIPEPLPEIPARLNSTWIEQQANELDIAPIILIGRLQKEGFLSWKTTLVRNAPTAIQYLEHWKAPLPVNP
>NZ_AP017369.1|WP_096459089.1|3351394_3351703_+|plasmid-maintenance-system-killer-protein
MDLVRVLFENEELQRAAEDPSYKPKRWSSDILKAYRRKIQFLRSAADERDLRALRSLNLEQLKGDRFGTSSIRLNKQYRLILKFLTEEDGRVVVVIELVDYH
>NZ_AP017369.1|WP_096459087.1|3349924_3351187_+|quinone-dependent-L-lactate-dehydrogenase
MVKRQLPNPAELLELMKFKKPELNGKKRRLDSALTIYDLRKIAKRRTPAAAFDYTDGAAEAELSIKRAREAFENIEFHPDILKPAEHVDTTTQILGGSSSMPFGIAPTGFTRLMQTEGEIAGAGAAGAAGIPFTLSTLGTTSIEDVKAANPNGRNWFQLYVMRDREISYGLVERAAKAGFDTLMFTVDTPIAGYRIRDSRNGFSIPPQLTPSTVLNAIPRPWWWIDFLTTPTLEFASLSSTGGTVGDLLNSAMDPTISYEDLKVIRELWPGKLVVKGVQNVADSVKLIDEGVDGLILSNHGGRQLDRAPVPFHLLPQVRKEVGNDPTIMIDTGIMNGADIVASVAMGADFTLIGRAYLYGLMAGGREGVDRTIAILRSEINRTMALLGVSSLEELEPRHVTQLAKMVPVSEATRTAAAEI
>NZ_AP017369.1|WP_096460326.1|3348588_3349890_+|MHS-family-MFS-transporter
MTTAVDQNSPPKQQLNRRVLLGSLSGSVIEWFDFLVYGTVAALVFNKMYFPSDNEFLSTILAYASFSLTFFFRPVGGVIFAHIGDRIGRKKTLFITLMLMGGGTVAIGLLPDYNSIGIWAPILLMFLRILQGIGIGGEWGGALLLAYEYAPKNQRGLYGAVPQMGISLGMLLAAGVISLLTLMPDEQFLTWGWRVPFVGSIILVFIGLFIRNGLDETPEFKRIRDSGQQVKMPLKEVLTKYWPAVLVSIGAKAAETGPFYIFGTYIVAYATNFLNIRDNMVLLAVACAALVATIWMPLFGSFSDKVNRAALYRICASATIVLIVPYYLILNTGEIWALFITTVIGFGILWGSVNAILGTVIAENFAPEVRYTGATLGYQVGAALFGGTAPIIAAWMFEVSGGQWWPIALYVAACCLISVIASFFIQRVAHQEN
>NZ_AP017369.1|WP_096459084.1|3347641_3348430_+|metallophosphoesterase
MSRTLWAVSDLHVTFAQNQKTVDALQPHNPGDWLIVAGDVAEKIPDVVRVLSGLAARFDTVIWVPGNHELFNRKTDRINGKARYRALVGQLRALGVITPEDPYPVFGGVTICPLFTLYDYSFRPLGFTAKQAVAQAKVKLDDELAIAPYVDIPQWCAERLSYTEDRLKATKGPKVLVNHWPLVIEPTHRLFEKDIALWCGTTATRDWAVRFNAVMAIHGHLHIPAETRVDGISHVEVSLGYPFEKHPPHLKRPWPFPVMQIN
>NZ_AP017369.1|WP_096459080.1|3346945_3347641_+|FadR-family-transcriptional-regulator
MSVKAHESVMDWVTEELRSGRLKLGDHLPSERSLSETLGVSRSSLREALRVLEALGTISTATGSGPRSGTIITAAPGQALSLSVTLQLITDQVGHHDIYETRQLLEGWSALHSNPERGDWAAAEALLEKMDDPSLPLEDFLLFDAEFHVVLSKGAENPLITTLMEALRLSVSDHTVARARALPNWSETSARLQKEHRAILKALRAGESVHAAELIKKHIEGYYEETAAAKA
>NZ_AP017369.1|WP_096459107.1|3356919_3357840_-|LysR-family-transcriptional-regulator
MNNDGGEMRIDDVRSFISVANSGHLTETADRLGIPQPTLSRRIGRVEKHAGTPLFDRAGRKLVLNQRGRAFLAHASAIVAEFDSAATEIKRLMDPEKGTIRLDFMHSLGTWMVPELIRTFRTEHPHVEFQLHQAAAMLLVDRVLADETDLALVGPKPAEVGTSLGWAPLLRQRLALAVPADHRLASGSGEIPLSEVAGEPFVAMRAGFGTRLLMDALAEKAGFVPNVVFESMELTTVAGLVSAGLGVGVVPMDDPYLPTVGIVQRPLNPPAYRELGLVWRLNAGPAPAVDNFREFVAGSRYALERS
>NZ_AP017369.1|WP_096459110.1|3357914_3359147_+|MFS-transporter
MMVPMSQAIDTKVTEYQGIERGTRNYKRAVFAMLAAGLAAFNGLYCTQALLPTMTAELGITPTQSALTVSATTGMLAVCIVPASILSEKFGRGRVLITSLSLAIIVGLILPLVPNITALILLRGLQGVLLAGTPAVAMTWLSEEIHPKDIGHAMGIYIAGNTVGGLTGRMIPAGLLEVTHWQNALLGSSVAALIFGAIMVMLLPKQRKFQPKNINVRHEFSAMTAHWRNPRLALLFLTAFLGMGTFVSLYNYLGFRMMDQFGLSEVLVGAVFIMYLAGTWSSTQAGALREKIGNGPTVIFLSLTMIASMAMMGINNLWITLVALFVFTAAFFALHSSASGWIGIIATHDRAEASSMYLFCYYVGSSVVGWGSGFVFTHLPWIAFIGWLVLLLCGVLGISITLAKLAHKVN
>NZ_AP017369.1|WP_096460329.1|3359261_3360809_+|hypothetical-protein
MVLVVAGLIHPLLPEYRWVLIHLFTLGAITNSIVVWSQHFTEKFLHLKLDDSKRPAQLMKIRLLNVGIIVTIIGQMVDQWIVTSVGATFVGLALAWHAGSLAAQFRSAKHGQPFASAVVAYVASACCLPFGAFAGALLSKELSGNLQERVLLTHSVINFLGFVGFAALGSLSVLFAAIWRTKIRRNFTPWSVGIMAIALPIIVAGILLDNGYVTAAGLAAYAAAWLLCMAGWGKASISNLSFSTSTSSTAPLWLVGTLAWLAVQAVIHNGELYHVEVPTIALVIGFGAQLLIGVMSYLLPSTMGGGASAVRTGTHILNTAGLFRWTLLNGGLAIWLLTDNSWLRVIVSLLSIGALAIFVILLPKAVRAQRGVITKTREPITPPEGPRLNQITAGISVLALILAAFGGLNPGVAPVASTNSDVYPVTITAGDMVFIPDVIEVPAGKSLEVTMINEDDMVHDLKFANGVQTGRVAPGDEITVTVGDISEDMEGWCTIAGHHAQGMDLEVKVPAPTQP
>NZ_AP017369.1|WP_167382144.1|3361263_3362775_-|TM0106-family-RecB-like-putative-nuclease
MQSERITPSDLVGCRYRQVQRIRFPEIAPLPATMQRRARREVGLMEVLDRLPQQPKKRGRNNFTRVDLDNEAELAEFDTLEAIAAGETLITGAVFSGTLDGVPWEVIADILVRNPDGTYMPVMVSNHRVARPDPHKTMKGIAVSRLGVGQPLEVKATLRHHTIDGYRLTLAMMGLEEAGVAPVSSFGAVVGQDRDWAYLVDVTRYAPAAHRALLTPTPSAPRRVKECSTCRFWPKCEPELKAADDISLFLSGDRADTYREKGIHTTTALIEANLGEISHIAAAWRDDIPVLRRTEHTTAPRFDVEIDVDVEAYLDLGAYLWGAWDGKTYIPFVIWSDLGSEAEGENFAQFWSWLKARRDKARQQGQTFGVYCYASNGENHWMLSTARRFYGKVKGVPSEQEIRGFISSDQWNDMFAVARSQLVGPGGLGLKQLAPAAGFHWEEEDFAGEDSLHAYLIASTAPEPEAEAARAQLLSYNGDDCRATAAVRHWLRKGARSAPVLGA
>NZ_AP017369.1|WP_096459116.1|3362870_3363506_+|hypothetical-protein
MGIFEAIRSARAKTKAEIKAAEAKVKTEAKNKAKLDLKREKLLVQQEKNLLKAEDKGLKKRNKHELKMAKNILEQKRQGRLNKDKVKRWAGTARVLTPLLLPIIYRLSTEARDQVVKSRARRAGVTAEQLSQFAGHAAALKARIQGVRDTAKNSGLPSGFVRDVEERLDELEAAANNSEFMSPQQRHRAHQSIDRDLNQVSDQIQDRLLDK
>NZ_AP017369.1|WP_096459119.1|3363530_3364169_-|response-regulator-transcription-factor
MIRVLLADDHEIVRLGLRAVLESAEDIEVVGEVSTAEGAVQAAQAGGIDVILMDLRFGPGVQGTQVSTGADATAAIKRTIENPPKVLVVTNYDTDADILGAIEAGALGYLLKDAPPSELLAAVRSAAEGDSTLSPMVANRLMTRVRTPKTSLTPRELEVLKLVAGGSSNRDIGRILFLSEATVKSHLVHIYDKLGVRSRTSAVAAAREQGLL
>NZ_AP017369.1|WP_096459122.1|3364289_3365600_-|sensor-histidine-kinase
MQSSLDRVSESGRNELDVETLVKRGNQPGAMSYRNSIHILTATLLVVGLGASARLTLPMFALSCVLLFVWGFFYFYGSTKRVDFSHGVQLAWLFALSLVWIVMVPIVPVSIYLLFPLFFLYLQVMPDVRGIIAVVGATAVAVASQYSVGLTFGGVMGPLVSAIVTVAIDYAFRTLWRVNNEKQQLIDQLIETRSQLAVTERNAGIAEERQRIAHEIHDTVAQGLSSIQMLLHVSEQEILAAEMEEKSKDAIVKKMRLARQTASDNLSEARAMIAALQPAALSKTSLEGALHRVTEPLLGINFVISVDGEVRQLPMKTEATLLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVVDDGVGFEPSEISSTPAGLGHIGLSALHQRAVELHGEVIVESAYGQGTAVSAALPVEPPTDPEVGSPTSGHGEFSAELDN
>NZ_AP017369.1|WP_096459125.1|3365598_3366156_+|DUF2020-domain-containing-protein
MRRTLPIFLAASIMLTACAAEKPAEEVPVEVAPSVAPEVITDGLPIDAMPAVARTEQTACPYLDTDWVADTNGQRVTGYGIDERFSTPSCVYYSFPEEPQLTVIVRDMATTDEAIAVVDWAAPIDSTEPAEEPTGWSGGRRGGNNNSGALYAVQKGPTAVIVFTNQDQSLKAQLIAEEVIQNLNL
>NZ_AP017369.1|WP_096459128.1|3366429_3366582_-|hypothetical-protein
MYSLLWHYLPGPWFVKLLIVIALIAVVFFVLMEVVFPLVSTLMPYNDVAF
>NZ_AP017369.1|WP_096459131.1|3366582_3367422_-|sortase
MTATLNTESPHPDKGAGKPRPQISVSQIIGELLLTIGILALLFAFYEAYWTNVESGKLQESASQKLDEDWEQERDRVNPRQKLTPELGEAFARMYVPSFGSDFNFAIIEGTDEADLLAGPGRYVDSQMPGEAGNFAVAGHRVGKGAPFNDLGNLEVCDAIVVETFNSWDVYRVMPLSTNGSDRAAEAVDCFDETQVNRMAEGDYASVLGRSITTPDRIDATYPIPGVFDTTVAEGAEALLTLTTCHPQFSNAERMIVHAMLAEEIDKSSGERPAALEEN

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Crispr_ID: NZ_AP017369_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP017369_12

3486137-3486219

Orphan

Consensus_repeat	Method
ATGTTTCACGTGAAACATTGGGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP017369_12

>merge|NZ_AP017369|12|3486137-3486219|CRISPRCasFinder
ATGTTTCACGTGAAACATTGGGGAGGTGCCGGACATATTTTCAGAATCTATTTTCCGGATGTTTCACGTGAAACATTGGGAGT

>NZ_AP017369|12|12|3486137-3486219|CRISPRCasFinder
ATGTTTCACGTGAAACATTGGGGAG	GTGCCGGACATATTTTCAGAATCTATTTTCCGG
ATGTTTCACGTGAAACATTGGGAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP017369.1\|WP_096459348.1\|3470913_3471819_-\|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl\|CDD\|239544
NZ_AP017369.1\|WP_096459370.1\|3479659_3480745_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|275173
NZ_AP017369.1\|WP_096459394.1\|3498376_3499414_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|225722
NZ_AP017369.1\|WP_096459376.1\|3487544_3488306_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|183775
NZ_AP017369.1\|WP_096459382.1\|3491989_3492754_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_AP017369.1\|WP_096460362.1\|3494439_3497055_-\|aconitate-hydratase-AcnA	unknown	unknown	gnl\|CDD\|237246
NZ_AP017369.1\|WP_096459388.1\|3493937_3494426_-\|ribonuclease-E-activity-regulator-RraA	unknown	unknown	gnl\|CDD\|236487
NZ_AP017369.1\|WP_096459379.1\|3488312_3490340_-\|acetoacetate--CoA-ligase	unknown	unknown	gnl\|CDD\|235134
NZ_AP017369.1\|WP_096459358.1\|3474948_3476439_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NZ_AP017369.1\|WP_096459364.1\|3477733_3478615_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_AP017369.1\|WP_096459361.1\|3476627_3477707_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_AP017369.1\|WP_096459373.1\|3481703_3486092_+\|phosphoesterase	unknown	unknown	gnl\|CDD\|277344
NZ_AP017369.1\|WP_096459385.1\|3492756_3493641_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|225070
NZ_AP017369.1\|WP_096459367.1\|3478639_3479647_+\|inositol-2-dehydrogenase	unknown	unknown	gnl\|CDD\|275173
NZ_AP017369.1\|WP_096460356.1\|3486401_3487424_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP017369.1\|WP_096459345.1\|3470180_3470741_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182632
NZ_AP017369.1\|WP_096460359.1\|3490374_3491736_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|273327
NZ_AP017369.1\|WP_096459391.1\|3497411_3498098_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_AP017369.1\|WP_096459355.1\|3473013_3474516_-\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|365860
NZ_AP017369.1\|WP_096459352.1\|3471828_3472923_-\|maleylacetate-reductase	unknown	unknown	gnl\|CDD\|341456

Protein	Function_ID	Function_description	E-value
NZ_AP017369.1\|WP_096459348.1\|3470913_3471819_-\|intradiol-ring-cleavage-dioxygenase	gnl\|CDD\|239544	cd03461, 1,2-HQD, Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form 3-hydroxy-cis,cis-muconates. 1,2-HQD blongs to the aromatic dioxygenase family, a family of mononuclear non-heme intradiol-cleaving enzymes.	1.19838e-142
NZ_AP017369.1\|WP_096459370.1\|3479659_3480745_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|275173	TIGR04380, hypothetical_protein_HOLDEFILI_04020, inositol 2-dehydrogenase. All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars].	1.57488e-96
NZ_AP017369.1\|WP_096459394.1\|3498376_3499414_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	4.80102e-72
NZ_AP017369.1\|WP_096459376.1\|3487544_3488306_-\|SDR-family-oxidoreductase	gnl\|CDD\|183775	PRK12826, PRK12826, SDR family oxidoreductase.	1.43871e-90
NZ_AP017369.1\|WP_096459382.1\|3491989_3492754_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.30984e-49
NZ_AP017369.1\|WP_096459388.1\|3493937_3494426_-\|ribonuclease-E-activity-regulator-RraA	gnl\|CDD\|236487	PRK09372, PRK09372, ribonuclease E inhibitor RraA.	1.40812e-67
NZ_AP017369.1\|WP_096459379.1\|3488312_3490340_-\|acetoacetate--CoA-ligase	gnl\|CDD\|235134	PRK03584, PRK03584, acetoacetate--CoA ligase.	0
NZ_AP017369.1\|WP_096459358.1\|3474948_3476439_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.27165e-66
NZ_AP017369.1\|WP_096459364.1\|3477733_3478615_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	7.1278e-28
NZ_AP017369.1\|WP_096459361.1\|3476627_3477707_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.53542e-57
NZ_AP017369.1\|WP_096459373.1\|3481703_3486092_+\|phosphoesterase	gnl\|CDD\|277344	cd07399, MPP_YvnB, Bacillus subtilis YvnB and related proteins, metallophosphatase domain. YvnB (BSU35040) is an uncharacterized Bacillus subtilis protein with a metallophosphatase domain. This family includes bacterial and eukaryotic proteins similar to YvnB. YvnB belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.76637e-93
NZ_AP017369.1\|WP_096459385.1\|3492756_3493641_-\|amidohydrolase	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	2.42198e-69
NZ_AP017369.1\|WP_096459367.1\|3478639_3479647_+\|inositol-2-dehydrogenase	gnl\|CDD\|275173	TIGR04380, hypothetical_protein_HOLDEFILI_04020, inositol 2-dehydrogenase. All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars].	1.86489e-132
NZ_AP017369.1\|WP_096460362.1\|3494439_3497055_-\|aconitate-hydratase-AcnA	gnl\|CDD\|237246	PRK12881, acnA, aconitate hydratase AcnA.	0
NZ_AP017369.1\|WP_096459345.1\|3470180_3470741_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|182632	PRK10668, PRK10668, DNA-binding transcriptional repressor AcrR; Provisional.	1.41052e-10
NZ_AP017369.1\|WP_096460359.1\|3490374_3491736_-\|MFS-transporter	gnl\|CDD\|273327	TIGR00895, transport_protein, benzoate transport. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.28225e-100
NZ_AP017369.1\|WP_096459391.1\|3497411_3498098_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.31309e-45
NZ_AP017369.1\|WP_096459355.1\|3473013_3474516_-\|sugar-porter-family-MFS-transporter	gnl\|CDD\|365860	pfam00083, Sugar_tr, Sugar (and other) transporter.	1.59314e-91
NZ_AP017369.1\|WP_096459352.1\|3471828_3472923_-\|maleylacetate-reductase	gnl\|CDD\|341456	cd08177, MAR, Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes. Maleylacetate reductase (MAR) plays an important role in the degradation of aromatic compounds in aerobic microbes. In fungi and yeasts, the enzyme is involved in the catabolism of compounds such as phenol, tyrosine, benzoate, 4-hydroxybenzoate and resorcinol. In bacteria, the enzyme contributes to the degradation of resorcinol, 2,4-dihydroxybenzoate ([beta]-resorcylate) and 2,6-dihydroxybenzoate ([gamma]-resorcylate) via hydroxyquinol and maleylacetate. Maleylacetate reductase catalyzes NADH- or NADPH-dependent reduction, at the carbon-carbon double bond, of maleylacetate or 2-chloromaleylacetate to 3-oxoadipate. In the case of 2-chloromaleylacetate, MAR initially catalyzes the NAD(P)H-dependent dechlorination to maleylacetate, which is then reduced to 3-oxoadipate. This enzyme is a homodimer and is inhibited by thiol-blocking reagents such as p-chloromercuribenzoate and Hg++, indicating that the cysteine residue is probably necessary for the catalytic activity of maleylacetate reductase.	2.61886e-172

>NZ_AP017369.1|WP_096459373.1|3481703_3486092_+|phosphoesterase
MKISKLGLRIAVTATATTTALTLGSSHMVVAQETDLLGNVAEALMAVPSDLVVTEILPDNTGYDNFEFFEVHNTGTSPVTIGEGEYTFSYSYDDAADTSRDKALDLGETITVDAGETIVVWIEYSTSTVDTAAFSEQEFRDFYGMDSSARIFRATGQSGLANGGDRGIRVLYNGEISGWSHYPSDSAAAQKGIDFALPQVGEQASVPVRTKTDPTPGMITADQLIPGGPTAPDEPEDPAGSLFEGLTSPSTAAPLILTELMVNSTNIGSSDGFEYVEITNTTAEPIDFSDYTLNYLYPQDEFTNTNAAVWAAEPGDVIIEPGKSLVFWIKNGPNDDATVADFNAEYGTNLEAGKDLVEISSGGMANGSARGMQIQTNTGHMVNRGFYNMAGASDVKTNQGLHYVVDESDLQKQSLLGSGAPTPGRVHKTQLPNPLSPVVADSSAPNITDNTAGSINPAEPFTFSFNIADDIQVRTATLNVTSSAGEAATTINLTEDNGTFSWTLPAADLTGKSWFEYTVSATDGFNHVTTEPVRVNVDGANTDPLRINLEENQWVSGTTDVIGASNVFGDKLELLIDDAPAVTNSSLSAAPTFAMEVTQTDTFFRNGILAGGEELHIFDQGTYANIETISTPVPLYHINEDGTLTVSVYAGTKAAPEIDLDENNDDFQIRNLRLILPDGRTLTPAGITDSNAWLNMGDSAGKLDFFDATFTLPEDAFTGVAHAWDTTESTDGEHYITISREDGESISRTVRVDNTAPELAVSGVEEGQELRGAVEINAQASDAGAGVKSIETLLDGERVQLPLTTGSIALDKGEHTLVIRAEDEVGNRTEKTITFSTPDENPISGDYAPSNGATVDVGDVKLSARASDPSGDALKMTFLEADAPKLDSGRIRMSSGTVEDAGSVKRNEAKLLERGDVEKLSSLDGLGVEVASDAALPYQLFEVDAADALAADTDVRLNWAGSADGRAQVIMYVFYGEAWVEVDRYLTGDELEEFTLQGTVNAEKFAIDGTVTVLIQHSEGFAGADHSTRISDVTAAHPDDVARSEYNFTLAWESDTQYYNQEFHEHQTKIHDYLLAERENKNIQFLFHTGDVVDDWDQPAQWDAANPEYQRLDEAGLPYSVLAGNHDVGHTSNDYTEFSRHFGEHRYADNPWYGESYKDNRGHYDLFSAGGIDFINVAMGWGPGDEEIAWMNDVLAKHPERVAIINLHEFMLTTGGLGPIPQRILDEVAATNPNVRMIMSGHYHDAFQRTDSFDDDGDGVDDRTVTSMLFDYQGLPEGGQGYLRLLHFDNQGQKMMVRTYSPSLEDYNSDDPSLMGPADDPNMYQEFDISYEQLGIKPEGRTLISDSFSADFLTSNEIGAVENTPSGEVASVVWKDVAEGRHSWFVRSEDQYGGIEISPVQSFIAGEEANGNEPGVGSSSGSSSHDLWGAIAGFFAGAAALAGAAFAFVPGIWDYVVGAFKR
>NZ_AP017369.1|WP_096459370.1|3479659_3480745_+|Gfo/Idh/MocA-family-oxidoreductase
MKNITIGMVGVGRIGRMHISNMLAVAEVLKERDINVDLVLADAMPGFAEQVGADLGVKAAESVDKLIEDGVDALFIATSTAGHVDVLRKGIEAKLPMFCEKPIASDVPESLDIIREIEAAGATVQVGHQRRFDLGYQEAKRRLEAGELGWLHSLKAVSGDAFPPPVSYCATSGGLFRDMSLHDFDIIRWLTSQDIVEVFAKGSNNGDPEIGAVGDIDTGAAMLTLADGTLATAIATRYNGAGHDVRLDVMGSKDSAIVGLDEKAAFASAEEGITFPSGESHPTFAERFADAYKNECIAFVELILGERENPCTPLDAVAAAIVADAAQLSLATGQPVKIPTVRDILDGSAEPVEVRALVPSA
>NZ_AP017369.1|WP_096459367.1|3478639_3479647_+|inositol-2-dehydrogenase
MTLRIALFGAGRIGHVHAANIVANPDLELVVIADPFIDGAKRLADATGAEAVATPDEVFARDDIDGIIIGSPTATHVDLITRAVEHGIPALCEKPIDLDIEMVRACKEKIGQGASKVMLGFNRRFDPSFAAINARVAEKEIGNLEQLVIISRDPAPAPKDYIAGSGGIFRDMTIHDLDMARFFVPNIVEVTATGSNVFSQDIAEFNDYDQVIVTLRGAEGELVNIVNSRHCSYGYDQRLEAFGSEGMLAADNITPTTVRKHNAEGTKQAEPIMNFFLERYSAAYQAELAAFAKGIRDGQGFSPSFEDGVIALELANACLESAQTGRTVSLTPINA
>NZ_AP017369.1|WP_096459364.1|3477733_3478615_+|sugar-phosphate-isomerase/epimerase
MKPQLIASCWTSAGDAAPDREDLSSPVSLDERIALVAETGWAGIGLVHADLIKARDTIGYEELRRRIHAAGIDIIEVEFLNGWWATGAERQESDATRADLFAAAKALGAPHIKVGAGEGTNGFVPIAQLSSAFTDLAAEAEDNGVKLALEATPFSHLKTIYDALEVVSHSDSPSAGLMVDIWHTAKIGIPNDELWRNIPLSKVNAVEVDDGFIDTPIDLFDDSTNRRAYCGEGEFDPASFIRGAIDAGWTGAYGVEIISAQHRSLPVKEGLQRAFDTTIAAFEQAARLAPSTN
>NZ_AP017369.1|WP_096459361.1|3476627_3477707_+|Gfo/Idh/MocA-family-oxidoreductase
MSDQKIVVGLLGITHPHASARVRALREIDGVEVIAAADTDPRLNYFTDKYDVEPREIDEVLNDDRINAIMVHSKSKDMVPHAKRALAAGKSVVVEKPGGGTVADLEELLELKNAADPSQIVQVGYNVRLSESIQRLKELVDAGLIGEVVSVQARGAAKVGEHITEHLNQPADMGGVLWILGCHMLDALVEVFGAPESVNARVHKTSKLSDESSREDSASALLYYPDFSVSFSFDGHDDLEWFESSRLTVYGTKGMIEAGILPQSLRVYLNESRQGWPQGWTEWTQSYFTPPFARTESNKFSELPELENISNFRTEMQGWVNSIRSGSKNVAPVEDALTVARIVQACYESDNNQGIAVKI
>NZ_AP017369.1|WP_096459358.1|3474948_3476439_+|helix-turn-helix-domain-containing-protein
MRTIQLLNKAGLLVNALAKGPKTHSELAKQLGEPRSSIYRITSSLEEVGLIQTNNEGQLGLGVRILHLGESAVDALVNRTLLRQNLGWLRDQLGMTAFFCTVQQDQIICLDRQEGADIDLIYLAPGRVLPSKKGAVAHVLQREGPPKSWSWDDGELASGVASVAVAVKDSSGNILGAVAVAGLSASIGNNTETIRDALRKTAVSIADMPPATTEEFDSSRINEPNSPSVIVKAATLLEVLRHEGQANSARLAEVLGEPISSVYRMLHTLTSIGWVEQDGKRGSYRIGLIMLSLAEAQLRHMDLRKIADQTMRNIHALTGETTFLCVRHGIRAVCIDRVDGDRVNSRVLQLGTSLPLHVGAAPRALLAFEGRRAWETYATNLGFEGHNWSKGPSRAELFQNLDEDRSKGFCLVDNEITPGIAAVGAPIYNHRGEVVASLSMSGLREGILQDNNDGQSAVELILQGSAEISKALGATILKDNGGNKTLPLPTPVSSVV
>NZ_AP017369.1|WP_096459355.1|3473013_3474516_-|sugar-porter-family-MFS-transporter
MTDIKASSSQPTTAAPIAGRPAKRLGQISLVACLGGLLFGYDTGVANGAEGHMAQELGLNVFQLGVVISSLVFAAAVGALFAGRISDAIGRRKAIISLAVLFFIGSILVVFSPAGEMGQFYGPGFAVLVAGRIMLGLAVGGASTVVPVYLAELAPLEIRGSLTGRNELAIVSGQLAAFVINAIIAVTLHGVIDGIWRIMFAVCALPAVALFLGMLRMPESPRWLVNQGRYDDARRVMETVRTPERAKTEMDEIIAVHSENSAAFAKTKKADEKHTHMSIKEVLINKWLVRLLIAGIGVAVAQQLTGINAIMYYGTRVLEESGMSAEMAVVANIAFGVVAVIGGLIALRNMDRLDRRTTFIIGLSLTTSFHILIAIAGTLLPEGNAARPIAIMVLVVGFVLSMQTFLNVAVWVWLAEIFPVRMKGIGTGISVFFGWGVNGVLALFFPALVSGVGITFSFLIFAVVGVIALTFVAKFVPETRGRSLEELDHAIFSGQIFKKA
>NZ_AP017369.1|WP_096459352.1|3471828_3472923_-|maleylacetate-reductase
MNNSLAFIHDTLPQKVMFGYGQSSTFLKQEVELRGSKKVMVIAGERELEIAQKVTSDIEVALWYDEVVMHVPIEVAERARQSAADNGIDLLVCVGGGSTTGLAKAIAMTTALPIVAVPTTYAGSEATNVWGLTEAQRKTTGVDLKVLPQTVIYDSELTMSLPVDMSVASGLNGLAHCIDSLWGPHADPINAALAAEGIRALNEGLPKIVADPHSIDGRDQALYGAYLAAVSFASAGSGLHHKICHTLGGTFNLPHAQTHATVLPYVLAFNAGDAPEAERRAAAAFGSDTALEGLQRLREAVDAPQRLSDYGFSADGIEEAVEVTLEKVPANNPRPVTKENLSKLLEAALNGEDPAVLSASHTLI
>NZ_AP017369.1|WP_096459348.1|3470913_3471819_-|intradiol-ring-cleavage-dioxygenase
MTSATTHHTISAQQHAVEEDLVDRVLQSFANCEDPRLKQVMESLVTHLHDFIRDVRLTEEEWNYAIEFLTQVGHITDDKRQEFVLLSDTLGASMQTIAVNNEAYENATEATVFGPFFVDDAPEVELGGDIAGGAQGQPAWVEGTVKDTDGNPIPNARIEVWECDEDGLYDVQYADQRMAGRAYLHTDANGEYRFWGLTPVPYPIPHDGPVGNMLQAVGRSPVRCAHLHFMVTAPGLRTLVTHIFVEGDPQLEAGDSVFGVKDSLIKKFEEQEPGTPTPDGRDLGDQTWARTRFDIVLAPGA
>NZ_AP017369.1|WP_096459345.1|3470180_3470741_-|TetR/AcrR-family-transcriptional-regulator
MNLKDLKAAETRRRFIDVAHELFLAQGYGPTSMNQIAQAAGGSRANLYLHFRNKPDLMMAKMRDIEPAVRAPVLKIFDLPEHTLDSILGWLNSMAEMWKEHAKEFGAMEQAMAEDAAVADEWLAMMQRLSHSVPELAEDEQRRFQFLASLMSMDRNFYFLYVRNQDTNEDLVKLAVARQWLAVFES
>NZ_AP017369.1|WP_096460356.1|3486401_3487424_+|hypothetical-protein
MALVGCSNTSGIAAFDGQSPSNTTSQVSPTAQITSAEPTPEEVLTTNAIAAYMGILSNPSTYPVSEAAQYVPNGTYSYAVVEATSDSIPELLLRVNSAEYSPVLVFTYDENTKTAVQAEGVFIDGASGAGGARSRIRASNSGVGIYQVDWNSLREIAQNTLYGIQDNTLTKVSGPEEFIFANSMPDHHEISWISASDKSGLFTIQRGDTSITPTLPTSTQAPAANLHHFSGMVTMQTANELMKGDPTPNGEPATDLYLVLVLDSPIEITAQKEGSAAQTSTISEVSLGQYIPTNGDNEWLNFLNTHVEITASADQVRFPTDTGLPLGMLRLGDYVSLRVL
>NZ_AP017369.1|WP_096459376.1|3487544_3488306_-|SDR-family-oxidoreductase
MSQQRVLITAGAGGIGWAIAQAFLNTNSLVHIVDVSAEAVDKVAGSHENLSTSIGDVTSVEDIAALASDLENRWGGLDVLVSNAGIAGPTAPVEEYDAGAWKAVMDINLTGSFNVVQHFVPLLKTSGGSILIMSSLAGRFGYPNRIAYSTSKWGLIGFTKTLSLELGPFGITVNSIHPGAVNGPRLEQVFAGRAEVSGRSVEAEMEAGLANQSIKKFTDPEDIAALAVFLAGPHARTISGQQFPIDGDSKAAQ
>NZ_AP017369.1|WP_096459379.1|3488312_3490340_-|acetoacetate--CoA-ligase
MSTAFAPESPEATITWNPTPEQVRSSRMADFARYSEVPAGRSLPDFHSLLDWSVTEVEAFWRSIQSYFDVIGEGFDTSEVLKEHVMPFASWFPGARVNFAENVLRHAHNPLLANEPAIYQVEEDGSHTVLSWVQLESQVASLAAIFKELGVERGDRIAAVLPNVPEAIIGLLAAASIGAVWTINSPDLSAEASIRRVKQLEPKVLVASDGYVFGGKEIDRREHTAEVEAGLPSLSATVLVRILDTQREPGVVSGKDVKRLAFDECVNKPHAPAYERVGFNDPLWILFSSGTTGEPKGIVHGHGGMVLDGLKNISLHQDIGPGDVYYVAANTSWMVWNTLVQNLLAGASVVTYAGSPKVTGKDHHFQIISDFGVTMFATGAAYLTMVEKAGIDPRAGRDFSALRSILSTGSPLPPSTWRWVHDAVKSDVHLGSDSGGTDICGGFLGSNPMEPVHLGYLQGPLLGVAVEAHDADGQPQIDQVGAMAVTKPLPSMPVMLWGDTDGSRYKSSYFTEGEGIWMHGDWITRTSSGEFIVHGRADATLNRQGVRIGPSDIYDALTDIEELSDYLVLGIEEDNGGYWMPLFVVLEDGVELDDALQQRICTTLRARTSARHVPDEIIVAPDIPVTHTMKRLEVPLKKFFSPQSAGREVNPDSVKNPDALAWFKEYAQQRSEAKE
>NZ_AP017369.1|WP_096460359.1|3490374_3491736_-|MFS-transporter
MTATINQSVRGPEQILAEVRSNKMSKFQIVTVTIALLMVVLDGFEVGIMAFAAPQIQEQLGISPDILGYVLSGSLFGMAIGSIFLTPLADRFGRRPLTLAMLTLIVVGMALTLTAPTALWLIVWRIVTGLGIGGMMANLNALVAEYSSDKRRTTAIAIYAAGYPIGATVAGFIARPLIPQFGWHSMFIAGTILAVVALIGAFALLPESLDYLLGRRPNRALERVNKILGKMNVAPLDALPERTITEEDRVSTKNIIREVLSPPTLRLTMALWLGYALLVAAYYFANTWIPTILTNVSGDPQLGTTMGIGANLGGVLGCFVFAALAIRFSGRHLLFITLFAAAAAYIIFGMVFSIIPVAIMVGFVLGVLTTGAIAGFYAVAPTIYSSKARATGIGWMIGIGRLVSVAAPIIVGYILAAGAEPEKVFLYFAIPLMIAGVAALTLLLGRTKATLAG
>NZ_AP017369.1|WP_096459382.1|3491989_3492754_-|IclR-family-transcriptional-regulator
MTSPNPDAAPVESVDRALRLLLYLRDHDSISVKEAAEYLDIAASTAHRLLSTLARRGFAIQDFSRRYRLGGIIMGSQQPKISHDVLRAAAMDPMTQLNASVRETVQVMVLSGGNIRFLDGVESDAILRVSRRVGDEMPAFVSSGGKVILGRLSNQEVEEIYRRGLIEWPTRKVTSLKMLKRMLTQVRRDGYAVSMEETEQGVVGVGVVILGSDARPVGAMTLAIPVSRYDKNRLPEYVDGLRKATAQVEEILFS
>NZ_AP017369.1|WP_096459385.1|3492756_3493641_-|amidohydrolase
MRYESAVDFDAIKAIDVHVHYETDTCGHHSMPQEFMDASAAYFKGGERVPSIDTIADLYRSLNMAAVVFTVDARTQLGHLPNSIDDLVAGTQKHNDVLIPFGSVDPRTGDDAIKEAIRQVEDLGVWGMKFHPSLQGFDPSDPQYRPLWKTLSDLGVTALFHTGQNGIGAGMAGGGGIKLRYSNPLLLDDIAAEFPNLRIIMAHPSVPWQDEANSIAIHKSNVFIDLSGWRPKYFPKSLVGYMSNMLSDKVLFATDYPLLAPEKWLADFEELPIKDEVRPKIFKDNALRALGVKK
>NZ_AP017369.1|WP_096459388.1|3493937_3494426_-|ribonuclease-E-activity-regulator-RraA
MTTTENLQRTSDLYDVHGDAFNSLAIDFHNFGGIEFFSGPAYTVDLFEDNGLLKTIMQQKGEGRVLVVNGHGSLACTLLGGNMAKILLDNGWSGTIINGTIRDRDELAALPFGCLALGSNPKRSLKDGAGREDITINFGGVDIHPGAMIYADSDGVLVEVQK
>NZ_AP017369.1|WP_096460362.1|3494439_3497055_-|aconitate-hydratase-AcnA
MDKTPITPTRTLNFRGTEYSYVHAADTLGPDFERWPVVLRLLAENVARCAAEEDRVQMLHGLRSWIDTQTSEREIHYLPGRLLMHDTTSTPALVDMAAMRDVVAAEGKDPELLNPLLPVEVSVDHSLAVESYATPNAARENIQHEIRRNRERYRFLKWAAASMDNIHINPPGTGIMHTINLEQLATVVTTEQRDGKNLIAPDMMLGTDSHTPMINGLGVLGWGVGGLEAETVMFGMPTTLKIPDVVGVYLHGTLPPAVLATDLALVITQELRKIGVTGEFVEFYGPGVSSLSVGDRAVIANMAPEYGATTGYFPIDSAVLTYLKSTGRSGEQQELVETYAQASGLWFNPEANPLFSRTISIDLSSLTPSVAGPRRPQDRIDLGSIPSALNNEGPAPHRDADTEWALPEYPVALASITSCTNTTDPRLLITAGLLARKARLRGLTPAPWVKTSLAPGSPAAQSYLKRSHLDEDLSAVGFDIVGFGCATCIGNSGALPEVIEQVRREGSSRPVAMLSGNRNFPGRVHPDLEFGFLMSPPLVVAYALAGDANKDISTEPIAIDATGQEVFLADLWPTPEEVDHVLEQAIDPEDFHRDFQHASNSRLWQSIDAPTSPLFPWDEGSTILRPPPFASRLNAAPEKLLEAYPLAVLGDDVTTDHISPASAIPQDSFIADFLVERGEKRDDLNVFASRRGNWEVMVRGAYYAKSLVNNLAVDAGTAMTTHGPTGQLMPICDAAQQYKKDNQAVVIIAGDRYGMGSSRDWAAKVQQLLGVRAVLASSFERIHRSNLIGMGILPLVVPAEIQQKLRTIEASTRILIDNDLDVLVPRGGVTVTVEQPDTTWSFVATAGVETGMDVDLLRSGGVIPKILDSIL
>NZ_AP017369.1|WP_096459391.1|3497411_3498098_+|GntR-family-transcriptional-regulator
MTRSFPQSLTKNDFAYVQLRELILTGALEPGSQLQQGRLAEEMGVSTTPLREAIRRLSSEGLITLAAHRDARVTNVTQREAEDLFTVRKQLDPLASELAAKERTEKELSAIQEAEQDLRPLTNDGNVEALLAHREFHRRIYLASHNDILIDMLERLWDKADRYRVIGLRLRGDSPEETERVAAEHHELVEAISAQDPARARKAMEDHINSSLGRRAIEVFEKANTSTT
>NZ_AP017369.1|WP_096459394.1|3498376_3499414_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MPDSPSPGNPRNPEKPPRTPLKTAISAIAALVGIGLVIAGVADASQSTSGANARSSLTLIAPAGAGGGWDGAARESQQTLRSEGIVNNPQVVNIPGAGGTIGLSQLSSMSGESTTVMVMGITMLGAININGSGVSIDDVTPIARLTDDYDVVVVAADSPINSVDDLVAEWKKDPSHFPFGGGSLGSLDQMIIAQLAQEAGIEPSSTNYMAHSGGAELATALLSGTIKASVSGFADFKDQIEAGRLKIIGVSAEQPIADINAPTLIEQGYDVSLTNWRGIVAPPGITDEERMELEEIFREMIATDTWRSTLERNQWTDTSLIGDDFAQNLQQETETVDNIWSNLGY

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP017369_1	1.1\|37077\|48\|NZ_AP017369\|CRISPRCasFinder	37077-37124	48	NZ_AP017369.1	3139583-3139630	0	1.0
NZ_AP017369_10	10.1\|3263839\|48\|NZ_AP017369\|CRISPRCasFinder	3263839-3263886	48	NZ_AP017369.1	3139583-3139630	0	1.0
NZ_AP017369_1	1.1\|37077\|48\|NZ_AP017369\|CRISPRCasFinder	37077-37124	48	NZ_AP017369.1	325514-325561	2	0.958
NZ_AP017369_1	1.1\|37077\|48\|NZ_AP017369\|CRISPRCasFinder	37077-37124	48	NZ_AP017369.1	1823979-1824026	2	0.958
NZ_AP017369_1	1.1\|37077\|48\|NZ_AP017369\|CRISPRCasFinder	37077-37124	48	NZ_AP017369.1	3186638-3186685	2	0.958
NZ_AP017369_3	3.1\|395548\|49\|NZ_AP017369\|CRISPRCasFinder	395548-395596	49	NZ_AP017369.1	588259-588307	2	0.959
NZ_AP017369_10	10.1\|3263839\|48\|NZ_AP017369\|CRISPRCasFinder	3263839-3263886	48	NZ_AP017369.1	325514-325561	2	0.958
NZ_AP017369_10	10.1\|3263839\|48\|NZ_AP017369\|CRISPRCasFinder	3263839-3263886	48	NZ_AP017369.1	1823979-1824026	2	0.958
NZ_AP017369_10	10.1\|3263839\|48\|NZ_AP017369\|CRISPRCasFinder	3263839-3263886	48	NZ_AP017369.1	3186638-3186685	2	0.958

1. spacer 1.1|37077|48|NZ_AP017369|CRISPRCasFinder matches to position: 3139583-3139630, mismatch: 0, identity: 1.0

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	Protospacer
************************************************

2. spacer 10.1|3263839|48|NZ_AP017369|CRISPRCasFinder matches to position: 3139583-3139630, mismatch: 0, identity: 1.0

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	Protospacer
************************************************

3. spacer 1.1|37077|48|NZ_AP017369|CRISPRCasFinder matches to position: 325514-325561, mismatch: 2, identity: 0.958

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcactttttcgacgtttgtgggtctcctggtttggtgtatcgctctc	Protospacer
***** ***********************.******************

4. spacer 1.1|37077|48|NZ_AP017369|CRISPRCasFinder matches to position: 1823979-1824026, mismatch: 2, identity: 0.958

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcacgttttcgacgtttgtgggtctcctggtttggtgtatcgctctc	Protospacer
*****.***********************.******************

5. spacer 1.1|37077|48|NZ_AP017369|CRISPRCasFinder matches to position: 3186638-3186685, mismatch: 2, identity: 0.958

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcacgttttcgacgtttgtgggtctcctagtttggtgtatcgcgctc	Protospacer
*****.************************************** ***

6. spacer 3.1|395548|49|NZ_AP017369|CRISPRCasFinder matches to position: 588259-588307, mismatch: 2, identity: 0.959

gtatcgcgctgaataccaaacgtggagacccaactttcggatttttgag	CRISPR spacer
gtatcgcgctgaataccaaacgtggagacccaactttcgggttttggag	Protospacer
****************************************.**** ***

7. spacer 10.1|3263839|48|NZ_AP017369|CRISPRCasFinder matches to position: 325514-325561, mismatch: 2, identity: 0.958

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcactttttcgacgtttgtgggtctcctggtttggtgtatcgctctc	Protospacer
***** ***********************.******************

8. spacer 10.1|3263839|48|NZ_AP017369|CRISPRCasFinder matches to position: 1823979-1824026, mismatch: 2, identity: 0.958

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcacgttttcgacgtttgtgggtctcctggtttggtgtatcgctctc	Protospacer
*****.***********************.******************

9. spacer 10.1|3263839|48|NZ_AP017369|CRISPRCasFinder matches to position: 3186638-3186685, mismatch: 2, identity: 0.958

atcacattttcgacgtttgtgggtctcctagtttggtgtatcgctctc	CRISPR spacer
atcacgttttcgacgtttgtgggtctcctagtttggtgtatcgcgctc	Protospacer
*****.************************************** ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	NZ_CP051472	Rhodobacter sphaeroides strain CH10 plasmid pRspCH10C, complete sequence	11503-11535	9	0.727
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	NZ_CP012965	Rhodobacter sphaeroides strain MBTLJ-8 plasmid unnamed, complete sequence	10932-10964	9	0.727
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	CP047035	Rhodobacter sphaeroides strain DSM 158 plasmid pC, complete sequence	11043-11075	9	0.727
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	NZ_CP047041	Rhodobacter sphaeroides strain 2.4.1 substr. H2 plasmid pC, complete sequence	11031-11063	9	0.727
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	NZ_CP015214	Rhodobacter sphaeroides strain MBTLJ-13 plasmid c, complete sequence	26264-26296	9	0.727
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	NZ_CP030275	Rhodobacter sphaeroides 2.4.1 plasmid pC, complete sequence	68985-69017	9	0.727
NZ_AP017369_4	4.1\|490694\|33\|NZ_AP017369\|CRISPRCasFinder	490694-490726	33	NZ_CP015292	Rhodobacter sphaeroides strain MBTLJ-20 plasmid d, complete sequence	15134-15166	9	0.727

1. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to NZ_CP051472 (Rhodobacter sphaeroides strain CH10 plasmid pRspCH10C, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

2. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to NZ_CP012965 (Rhodobacter sphaeroides strain MBTLJ-8 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

3. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to CP047035 (Rhodobacter sphaeroides strain DSM 158 plasmid pC, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

4. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to NZ_CP047041 (Rhodobacter sphaeroides strain 2.4.1 substr. H2 plasmid pC, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

5. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to NZ_CP015214 (Rhodobacter sphaeroides strain MBTLJ-13 plasmid c, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

6. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to NZ_CP030275 (Rhodobacter sphaeroides 2.4.1 plasmid pC, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

7. spacer 4.1|490694|33|NZ_AP017369|CRISPRCasFinder matches to NZ_CP015292 (Rhodobacter sphaeroides strain MBTLJ-20 plasmid d, complete sequence) position: , mismatch: 9, identity: 0.727

gcccgcaactttgcggtcggcgccgtcccagag	CRISPR spacer
gaaagctactttgcgggcggcgccgtcctgaac	Protospacer
*   ** ********* ***********...*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1770087 : 1780638

Paramecium_bursaria_Chlorella_virus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096459979.1\|1770087_1772754_+	cation-transporting P-type ATPase	M1HX51	Paramecium_bursaria_Chlorella_virus	1.6e-74	28.6
WP_096459982.1\|1772750_1773227_-	DUF1990 family protein	NA	NA	NA	NA
WP_096459985.1\|1773905_1774541_-	hypothetical protein	A0A1W6JQA2	Corynebacterium_phage	3.8e-19	39.5
WP_096455989.1\|1775305_1776937_-	ABC-F family ATP-binding cassette domain-containing protein	A0A1V0SKJ1	Klosneuvirus	5.1e-36	26.3
WP_096455991.1\|1777032_1777638_+	anti-sigma factor	NA	NA	NA	NA
WP_096455993.1\|1777725_1778139_-	metal-sulfur cluster assembly factor	NA	NA	NA	NA
WP_096455995.1\|1778163_1778613_-	SUF system NifU family Fe-S cluster assembly protein	A0A2P1CJL8	Mycobacterium_phage	1.2e-22	44.2
WP_096455997.1\|1778612_1779878_-	cysteine desulfurase	Q2XUY6	environmental_halophage	3.1e-89	41.5
WP_096455999.1\|1779879_1780638_-	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	7.2e-09	29.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP017369

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection