CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	2 crisprs	RT	1	15	2	0
NZ_AP018172	Calothrix sp. NIES-2098 DNA, complete genome	21 crisprs	csx21,csm3gr7,csx19,PD-DExK,csm2gr11,csx10gr5,cas10,Cas9_archaeal,RT,csa3,cas3,DinG,cmr5gr11,cmr4gr7,cmr3gr5,cas2,cas1,csx18,WYL,cas6,DEDDh	1	12	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP018173_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018173_1

8830-9451

Orphan

Consensus_repeat	Method
CTTGCCGATCACATTGCCCCGCAAGGGG-------ATGGAAAC	PILER-CR
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CRISPRCasFinder
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CRT

8 spacers

The CRISPR arrays of NZ_AP018173_1

>merge|NZ_AP018173|1|8830-9451|PILER-CR,CRISPRCasFinder,CRT
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAACTTTGAAGATCAAAACCTTTAGGAAACCGCGTTTTCCTTGCCGATCACATTGCCCCGCAAGGGGATGGAAACCAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTGCTTGCCGATCACATTGCCCCGCAAGGGGATGGAAACCAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTGCTTGCCGATCACATTGCCCCGCAAGGGGATGGAAACGCTGGGGACACACCTTGTGCAGCTGCTCCGGCACTTCTTGCCGATCACATTGCCCCGCAAGGGGATGGAAACCAGCTATGCTTTGTCCTATCAAAACAAAAACAAAAACAAAACTTGCCGATCACATTGCCCCGCAAGGGGATGGAAACTTCTTCTATTGTTCCCTTGGCATTAATCACATTAACTTGCCGATCACATCGCCCCGTAAGGGGATGGAAACAGGAGAATCTCAGCCACAAGCTTATCGACCTCCCAAGCTTTCCGACCACATCACCCCGCAAGGGGATGGAAACCCGAAACCGTCTCGCTTGGCTTGGATCATCGCAAGACTTTCCAATCGCATTACCCCGCAAGGGGATGAGAAC

>NZ_AP018173|1|1|8830-9306|PILER-CR
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	TTTGAAGATCAAAACCTTTAGGAAACCGCGTTTTC
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTG
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTG
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	GCTGGGGACACACCTTGTGCAGCTGCTCCGGCACTT
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGCTATGCTTTGTCCTATCAAAACAAAAACAAAAACAAAA
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	TTCTTCTATTGTTCCCTTGGCATTAATCACATTAA
CTTGCCGATCACATCGCCCCGTAAGGGGATGGAAAC

>NZ_AP018173|1|1|8830-9451|CRISPRCasFinder
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	TTTGAAGATCAAAACCTTTAGGAAACCGCGTTTTC
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTG
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTG
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	GCTGGGGACACACCTTGTGCAGCTGCTCCGGCACTT
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGCTATGCTTTGTCCTATCAAAACAAAAACAAAAACAAAA
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	TTCTTCTATTGTTCCCTTGGCATTAATCACATTAA
CTTGCCGATCACATCGCCCCGTAAGGGGATGGAAAC	AGGAGAATCTCAGCCACAAGCTTATCGACCTCCCAAG
CTTTCCGACCACATCACCCCGCAAGGGGATGGAAAC	CCGAAACCGTCTCGCTTGGCTTGGATCATCGCAAGA
CTTTCCAATCGCATTACCCCGCAAGGGGATGAGAAC

>NZ_AP018173|1|1|8830-9451|CRT
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	TTTGAAGATCAAAACCTTTAGGAAACCGCGTTTTC
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTG
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGAGACTCGTGCTTCACTCCAAACACCTTGAATATTTG
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	GCTGGGGACACACCTTGTGCAGCTGCTCCGGCACTT
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	CAGCTATGCTTTGTCCTATCAAAACAAAAACAAAAACAAAA
CTTGCCGATCACATTGCCCCGCAAGGGGATGGAAAC	TTCTTCTATTGTTCCCTTGGCATTAATCACATTAA
CTTGCCGATCACATCGCCCCGTAAGGGGATGGAAAC	AGGAGAATCTCAGCCACAAGCTTATCGACCTCCCAAG
CTTTCCGACCACATCACCCCGCAAGGGGATGGAAAC	CCGAAACCGTCTCGCTTGGCTTGGATCATCGCAAGA
CTTTCCAATCGCATTACCCCGCAAGGGGATGAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018173.1\|WP_096595534.1\|16990_17392_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|377579
NZ_AP018173.1\|WP_096595521.1\|3829_4429_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595517.1\|525_963_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595532.1\|15414_16377_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595533.1\|16466_16682_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595523.1\|6604_6826_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595531.1\|12473_13163_-\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|224442
NZ_AP018173.1\|WP_096595518.1\|1882_2458_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595525.1\|7088_7274_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595526.1\|7928_8195_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595535.1\|17375_17687_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_AP018173.1\|WP_096595529.1\|10899_11838_+\|ribonuclease-HI-family-protein	unknown	unknown	gnl\|CDD\|260011
NZ_AP018173.1\|WP_096595522.1\|4640_6494_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374724
NZ_AP018173.1\|WP_096595536.1\|17717_18641_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NZ_AP018173.1\|WP_096595524.1\|6895_7087_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369839
NZ_AP018173.1\|WP_096595519.1\|2734_2998_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225222
NZ_AP018173.1\|WP_096595528.1\|10448_10703_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595530.1\|11914_12466_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595527.1\|9815_10448_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|222854
NZ_AP018173.1\|WP_096595520.1\|3059_3335_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197713

Protein	Function_ID	Function_description	E-value
NZ_AP018173.1\|WP_096595535.1\|17375_17687_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.19682e-07
NZ_AP018173.1\|WP_096595522.1\|4640_6494_-\|hypothetical-protein	gnl\|CDD\|374724	pfam16684, Telomere_res, Telomere resolvase. Telomere resolvase (protelomerase) catalyzes the conversion of linear double-stranded DNA into hairpin telomeres.	5.5035e-12
NZ_AP018173.1\|WP_096595536.1\|17717_18641_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	4.08098e-36
NZ_AP018173.1\|WP_096595524.1\|6895_7087_+\|hypothetical-protein	gnl\|CDD\|369839	pfam08374, Protocadherin, Protocadherin. The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.	0.00115303
NZ_AP018173.1\|WP_096595519.1\|2734_2998_+\|hypothetical-protein	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	0.00210534
NZ_AP018173.1\|WP_096595529.1\|10899_11838_+\|ribonuclease-HI-family-protein	gnl\|CDD\|260011	cd09279, RNase_HI_like, RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII); however, a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif, they lack other common features important for catalytic function, such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.	1.20639e-48
NZ_AP018173.1\|WP_096595531.1\|12473_13163_-\|thermonuclease-family-protein	gnl\|CDD\|224442	COG1525, COG1525, Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair].	2.86898e-40
NZ_AP018173.1\|WP_096595520.1\|3059_3335_-\|hypothetical-protein	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	0.00373609
NZ_AP018173.1\|WP_096595527.1\|9815_10448_+\|AAA-family-ATPase	gnl\|CDD\|222854	PHA02518, PHA02518, ParA-like protein; Provisional.	2.87387e-63
NZ_AP018173.1\|WP_096595534.1\|16990_17392_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|377579	pfam05973, Gp49, Phage derived protein Gp49-like (DUF891). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	2.77694e-13

>NZ_AP018173.1|WP_096595526.1|7928_8195_+|hypothetical-protein
MISEISLLFPTFYRLLNTLAIANSFRLQSKTKNDLEINKSENQGKKIVHNADQEIIDDPGSEAIFFGWTDDFFLVNFDYKLIPINKND
>NZ_AP018173.1|WP_096595525.1|7088_7274_-|hypothetical-protein
MEAKSQIRWKKIALPIVLGVIASCAVATAFRYWQAKTEGWCIRYYPDGKKEVLYGNECQSK
>NZ_AP018173.1|WP_096595524.1|6895_7087_+|hypothetical-protein
MKSESFVIALLVAILILVNALTILIAPIVRHCWAKYQHYRFIQKRRRQFYQELKILMSDRAIA
>NZ_AP018173.1|WP_096595523.1|6604_6826_+|hypothetical-protein
MNKPQKKRATNPRLKNKDVCMLLTIAKPQQSQLSNDYYDGQFDAAIGLSPKTYEGDYFKGYLDKVNESGVTPF
>NZ_AP018173.1|WP_096595522.1|4640_6494_-|hypothetical-protein
MSKAVQEQVNQLFEAVKDLKSLDEIKPYCESFNEWLNTSTNYSKASLGTVLSRAGFYKKFKSLPLEQGKNAESVSKHDAQGNVTGYELKHYALLLCGLDKKDWEERNETTRVSDRLMTADEDGNTGIEINPEEYLEVTGSLLASDNPHELAVGLIASTGRRPHEILARGKFTAVEEESYQLMFEGQGKKRGEKPVFKISTLFPASYVIERFYHLRKDASIKELLKQVSNEFPRDVAAQNKAIEDRRGNSLRRVVQEYYGGKDSKEPLLNFRHGQDQNDCKALRAACACLVTERDRPGSVGSKMFFYATFLGHITPGEKLSDRELSHIVTSLGYADYYVTKPVGFPDAPEKERDCNIKATLPDWEFVKQLQEDLELPNQKAVTAKLVERYKNSESIAQQLKEAQQEVAQLKAKVKQLEEFNNQLQATNNQLQQENAAMETTTQEPKTVTLNITELEAWLEKKVVEVVGKVAGSVAIPAITATPVKVAPPKEEIDWQTKTDAEVWGSKAPGASLEKIRRSYQAICLYNDTVATGDGDRLAITNQALRDLSGCNGLLVRDWIDQHKDEVISHNTKYGMENKKDPSNPASYANKGKDTDKILSLVNEEFLSGEGYRKAKSE
>NZ_AP018173.1|WP_096595521.1|3829_4429_+|hypothetical-protein
MTIKILINKQMHFIGNYIVNVIEPRYGLSTSAKLELAKQNDMPESGLWEFEWQELWHKTDFEYQNIIKITCDNLLQGLIRYAVYTDEDSDQPYLLEILHLEAIPEDERLVSPLGRWLIWYAVQVAFRYCTPSETGELIYLDSTEDAISYYRDIVEMESLGWVSIAPGEDGHAFRFTVAGAKDFCERQTRDYGKPKLCTV
>NZ_AP018173.1|WP_096595520.1|3059_3335_-|hypothetical-protein
MNSISQATVIIHRELENANSWLTSADLEETTGYSRATVVRRLNILMQEGIVVCQIVRPHWFYKLADEPSNIQLLNQLKSIQTTEELLARTT
>NZ_AP018173.1|WP_096595519.1|2734_2998_+|hypothetical-protein
MTKLVTPRLLKTYLAIKESPNWLTADSIAEISGNKPDTVRKHVRYLSREKVLEVFEMRPAYYYQLSQNISDIWVVQQLEVLLTTVGS
>NZ_AP018173.1|WP_096595518.1|1882_2458_+|hypothetical-protein
MEQKAHQEENTKEINDLYCAIGEFVIEFEQVCFAISMNISITLLANGLENANIGHIFLAGMTASPLGEIFSSLIPEVKNLDQQEKTIVKQIFSRFQALFQKRNDIIHATWFLPLNANSMEFETANGIKFHKSKKGFEIKNLKYTVKTFKELTAEAKTLRAIFYRLGVCIYDDYDIKDNFFIDADGNVSEQF
>NZ_AP018173.1|WP_096595517.1|525_963_-|hypothetical-protein
MTVMTNIQELIEKLQQLEKEREQLLKTPMSPPGVWIHEYTITRRYPGSGNIEHYVYAKWQADKPIFKRHPKPRLEGIVKKGKDREFTCHQHIGRVGSSTGLGMDDKVEDAYEEWNNRKRLEAIDQALKEIEIALTKVMPQETNEA
>NZ_AP018173.1|WP_096595527.1|9815_10448_+|AAA-family-ATPase
MIISVQNQKGGVGKTTLAIHISHGLVLKGHSVLLVDADPQGSSRDWAAARGEKPPFPVVGLDRPTIHRDLPALAKDYDDVVIDGPPRVSDLARSAIIAADVVVIPIQPSPYDIWAADEVIKLIKEASVFKENIKAVFVINRKIVNTAIGRDVVEALEQYPFSVLKSAISQRVVFAESAATGNTVLEVDKNGSAAKEVKALVNELLKLGVE
>NZ_AP018173.1|WP_096595528.1|10448_10703_+|hypothetical-protein
MSAKKVNFGKKPEARESVDLEQWVSDRESLVSQPEQAQPEKMKRLTLDIPESLHKAIKRQAVDAGVTMADLLRDLLEQHYGTKQ
>NZ_AP018173.1|WP_096595529.1|10899_11838_+|ribonuclease-HI-family-protein
MNKRKKHVDDEHFCRIYFDGATQLTNPGEAACGAVLESPDGESINISKALGWQTNNYAEYSGLIIGCEKALELGYKGVSIKGDSQLVVNQINGYYQVRSESLQLLHKQALSLLHQFDFYVVKWIPRHENEQADAVAGSALLPIQHQTLVLRDNFPAELPIVSPRKGLEEQIQKLLTKGENAQLYDYLNIKSGRDEFSSKRLTALVKLLPEEVKEALASQLKEGEDEEFLGICYRWYLRGLPVQFALRKARVDLEARNSFNSSPASIPSSREQQTETVSYFCLNCGREWSELVKRDSFIGRVTCLDCDSGNVI
>NZ_AP018173.1|WP_096595530.1|11914_12466_-|hypothetical-protein
MGRQCWYFTKGGNMSYIYLIECETESSEIVTKIGVSTAPERRIIQWLDLIQISYLKFQNITYNDIYTNPSNQHIEKYNISDIKQHIVKQVDENFKIFQLDSCGSAEYLERHLHEYLLTNKKRPILYFGNIKECPISISKEFYQLKIDEVVRVMKNKNRLLPVKFKKNTECYTKYLSRKAKREL
>NZ_AP018173.1|WP_096595531.1|12473_13163_-|thermonuclease-family-protein
MNKTAVLAIAAMLISGLPSVAQTNLPAMTVVSVGDGDTLRARNQQGQAVTIRLACIDAPELKQQPWGQQSAARLKQLLPAGQSIKVRQVDRDKYKRVVAEVYVGDRSINLNMVQEGQAVVYRQYLKGCASTKDQFLKAEATAKQQNLGFWNQTKPVMPWIFRQGKGTTTQPVVSQPQQQQQCDPSYPDFCLSPNSPDLDCKDIPYRRFRVNQPDPHKFDRDKDGIGCER
>NZ_AP018173.1|WP_096595532.1|15414_16377_-|hypothetical-protein
MVQSYCKDTAIQLIHGFSTGNIRDFIKMSTEQAEIEQPTETKQETPTGIFQAVGIVTGDVTFIKDDERNKYIANITIGQYQYNLLPLGSSRSKLASFNGLRKEIESTGISRQKLIVYPKVTHYPGREQQHRIAFQLVAFEPINVENSISKELNEFEFKLSGLWQFIPVCRTPCITVMKNFSDERLEYIKQAELASKVNFMKASHIPLIWKDTPVKPFRFNPKLEKEQQGKAMFVSIKARFIPGKDMFGFDSLLGMPQDEPPKYLKAGKKDKAEVLKSKLARKRQNTGNVTIKPKVIEKNQNQTGISSAAVVEKPKLKPKS
>NZ_AP018173.1|WP_096595533.1|16466_16682_+|hypothetical-protein
MDLLRHGIEHFGYANLYDCDGENGSYAYLLKDPKLFRQRFTIKGKQPIFWKPQDASEQRIFAAAWQLINKG
>NZ_AP018173.1|WP_096595534.1|16990_17392_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MPKTRVVFYQEEEGKVPVLEWLTRLLKEDRKGYANCVARIKQLAASGYELRRPVADYLSDGIYELRAKHIHVQYRILYFFHGQNVAILAHAITKEEAAVPPIDIERASARKLLFEKNPEAHTYVEEEDNGFDQ
>NZ_AP018173.1|WP_096595535.1|17375_17687_+|helix-turn-helix-transcriptional-regulator
MASTNDAIKIIDKLTSRDPELEAMVAEASINAEVAQLIYEARTSSGLTQKQLAELIGTKQPVIARLEDADYEGHSLSMLQKIAQALNQRVVIHLTPLSHEQSA
>NZ_AP018173.1|WP_096595536.1|17717_18641_-|ParB/RepB/Spo0J-family-partition-protein
MPPRKSNRVAPKLNTVDAFLSSSSNSSSTTAPIEKIRLPLKQPRRYFDPEKLAQLVQSVREHGILEPLLVRPLHDGEYELVAGERRLRAAREVGLGEIPIVSHELDDKQALQVALMENLQREDLNPVEETEAVLEILSLSLEIQPSEVVSILHQSFNAKQRGIELNQNVLIQLEQIETVLSQIGRFNAGTFRSSRIPLLNLPDDILSVLRQGEIEYTKAQAIARVKSEQLRSDLLKIAIAENLSLSEIKTKIKELTPETETTPDRVLAQRLAEISKRLQKNKGVSVQKNRTRILKLLDELEKLTSEN

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Crispr_ID: NZ_AP018173_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018173_2

14870-15260

Orphan

Consensus_repeat	Method
CTTTCCTAAACAACTACCCCTTACGGGGATGGAAAC	CRISPRCasFinder
ACTTTCCTAAACAACTACCCCTTACGGGGATGGAAACCA	PILER-CR

5 spacers

The CRISPR arrays of NZ_AP018173_2

>merge|NZ_AP018173|2|14870-15260|CRISPRCasFinder,PILER-CR
CTTTCCGATCACATTGCCCCGCAAGGGGATGGAAACAAGGTGAAGAAGTCGAATCCGAATTCTCCTCGGAAGCTTTCCATAACCACTTCCCCTAACGGGGATGGAAACATATTATTCTGGGGGTTAACCAGCAAGTTATAGTCACTTTCCTAAACAACTACCCCTTACGGGGATGGAAACAAAAAATAATCATAGGGAATGTATCATTTATACTTCTTTCCTAAACAACTACCCCTTACGGGGATGGAAACCAGTAGATCCAGCTTGTTTGCTTGTGGAATAGGTTGACTTTCCTAAACAACTACCCCTAACGGGGATGGAAACCCTATGGTTATAAACATAGCTTCTGGTTTTCCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC

>NZ_AP018173|2|2|14870-15260|CRISPRCasFinder
CTTTCCGATCACATTGCCCCGCAAGGGGATGGAAAC	AAGGTGAAGAAGTCGAATCCGAATTCTCCTCGGAAG
CTTTCCATAACCACTTCCCCTAACGGGGATGGAAAC	ATATTATTCTGGGGGTTAACCAGCAAGTTATAGTCA
CTTTCCTAAACAACTACCCCTTACGGGGATGGAAAC	AAAAAATAATCATAGGGAATGTATCATTTATACTT
CTTTCCTAAACAACTACCCCTTACGGGGATGGAAAC	CAGTAGATCCAGCTTGTTTGCTTGTGGAATAGGTTGA
CTTTCCTAAACAACTACCCCTAACGGGGATGGAAAC	CCTATGGTTATAAACATAGCTTCTGGTTTTC
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC

>NZ_AP018173|2|2|15013-15195|PILER-CR
ACTTTCCTAAACAACTACCCCTTACGGGGATGGAAACAA	AAAATAATCATAGGGAATGTATCATTTATACT
TCTTTCCTAAACAACTACCCCTTACGGGGATGGAAACCA	GTAGATCCAGCTTGTTTGCTTGTGGAATAGGTTG
ACTTTCCTAAACAACTACCCCTAACGGGGATGGAAACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018173.1\|WP_096595540.1\|20571_25485_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018173.1\|WP_096595534.1\|16990_17392_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|377579
NZ_AP018173.1\|WP_096595537.1\|18640_19405_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_AP018173.1\|WP_096595533.1\|16466_16682_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595523.1\|6604_6826_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595531.1\|12473_13163_-\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|224442
NZ_AP018173.1\|WP_096595524.1\|6895_7087_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369839
NZ_AP018173.1\|WP_096595525.1\|7088_7274_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595539.1\|20175_20364_+\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NZ_AP018173.1\|WP_096595526.1\|7928_8195_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595535.1\|17375_17687_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_AP018173.1\|WP_096595529.1\|10899_11838_+\|ribonuclease-HI-family-protein	unknown	unknown	gnl\|CDD\|260011
NZ_AP018173.1\|WP_096595522.1\|4640_6494_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374724
NZ_AP018173.1\|WP_096595541.1\|25481_26777_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|284995
NZ_AP018173.1\|WP_096595538.1\|19751_20060_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|240845
NZ_AP018173.1\|WP_096595532.1\|15414_16377_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595536.1\|17717_18641_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NZ_AP018173.1\|WP_096595528.1\|10448_10703_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595530.1\|11914_12466_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018173.1\|WP_096595527.1\|9815_10448_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|222854

Protein	Function_ID	Function_description	E-value
NZ_AP018173.1\|WP_096595540.1\|20571_25485_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	8.30494e-84
NZ_AP018173.1\|WP_096595537.1\|18640_19405_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	2.08177e-64
NZ_AP018173.1\|WP_096595524.1\|6895_7087_+\|hypothetical-protein	gnl\|CDD\|369839	pfam08374, Protocadherin, Protocadherin. The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.	0.00115303
NZ_AP018173.1\|WP_096595531.1\|12473_13163_-\|thermonuclease-family-protein	gnl\|CDD\|224442	COG1525, COG1525, Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair].	2.86898e-40
NZ_AP018173.1\|WP_096595541.1\|25481_26777_-\|AAA-family-ATPase	gnl\|CDD\|284995	pfam07693, KAP_NTPase, KAP family P-loop domain. The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.	0.000850273
NZ_AP018173.1\|WP_096595539.1\|20175_20364_+\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	5.01594e-15
NZ_AP018173.1\|WP_096595538.1\|19751_20060_+\|RNA-binding-protein	gnl\|CDD\|240845	cd12399, RRM_HP0827_like, RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins. This subfamily corresponds to the RRM of H. pylori HP0827, a putative ssDNA-binding protein 12rnp2 precursor, containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The ssDNA binding may be important in activation of HP0827. .	4.42746e-33
NZ_AP018173.1\|WP_096595535.1\|17375_17687_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.19682e-07
NZ_AP018173.1\|WP_096595522.1\|4640_6494_-\|hypothetical-protein	gnl\|CDD\|374724	pfam16684, Telomere_res, Telomere resolvase. Telomere resolvase (protelomerase) catalyzes the conversion of linear double-stranded DNA into hairpin telomeres.	5.5035e-12
NZ_AP018173.1\|WP_096595536.1\|17717_18641_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	4.08098e-36
NZ_AP018173.1\|WP_096595529.1\|10899_11838_+\|ribonuclease-HI-family-protein	gnl\|CDD\|260011	cd09279, RNase_HI_like, RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII); however, a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif, they lack other common features important for catalytic function, such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.	1.20639e-48
NZ_AP018173.1\|WP_096595534.1\|16990_17392_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|377579	pfam05973, Gp49, Phage derived protein Gp49-like (DUF891). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	2.77694e-13
NZ_AP018173.1\|WP_096595527.1\|9815_10448_+\|AAA-family-ATPase	gnl\|CDD\|222854	PHA02518, PHA02518, ParA-like protein; Provisional.	2.87387e-63

>NZ_AP018173.1|WP_096595531.1|12473_13163_-|thermonuclease-family-protein
MNKTAVLAIAAMLISGLPSVAQTNLPAMTVVSVGDGDTLRARNQQGQAVTIRLACIDAPELKQQPWGQQSAARLKQLLPAGQSIKVRQVDRDKYKRVVAEVYVGDRSINLNMVQEGQAVVYRQYLKGCASTKDQFLKAEATAKQQNLGFWNQTKPVMPWIFRQGKGTTTQPVVSQPQQQQQCDPSYPDFCLSPNSPDLDCKDIPYRRFRVNQPDPHKFDRDKDGIGCER
>NZ_AP018173.1|WP_096595530.1|11914_12466_-|hypothetical-protein
MGRQCWYFTKGGNMSYIYLIECETESSEIVTKIGVSTAPERRIIQWLDLIQISYLKFQNITYNDIYTNPSNQHIEKYNISDIKQHIVKQVDENFKIFQLDSCGSAEYLERHLHEYLLTNKKRPILYFGNIKECPISISKEFYQLKIDEVVRVMKNKNRLLPVKFKKNTECYTKYLSRKAKREL
>NZ_AP018173.1|WP_096595529.1|10899_11838_+|ribonuclease-HI-family-protein
MNKRKKHVDDEHFCRIYFDGATQLTNPGEAACGAVLESPDGESINISKALGWQTNNYAEYSGLIIGCEKALELGYKGVSIKGDSQLVVNQINGYYQVRSESLQLLHKQALSLLHQFDFYVVKWIPRHENEQADAVAGSALLPIQHQTLVLRDNFPAELPIVSPRKGLEEQIQKLLTKGENAQLYDYLNIKSGRDEFSSKRLTALVKLLPEEVKEALASQLKEGEDEEFLGICYRWYLRGLPVQFALRKARVDLEARNSFNSSPASIPSSREQQTETVSYFCLNCGREWSELVKRDSFIGRVTCLDCDSGNVI
>NZ_AP018173.1|WP_096595528.1|10448_10703_+|hypothetical-protein
MSAKKVNFGKKPEARESVDLEQWVSDRESLVSQPEQAQPEKMKRLTLDIPESLHKAIKRQAVDAGVTMADLLRDLLEQHYGTKQ
>NZ_AP018173.1|WP_096595527.1|9815_10448_+|AAA-family-ATPase
MIISVQNQKGGVGKTTLAIHISHGLVLKGHSVLLVDADPQGSSRDWAAARGEKPPFPVVGLDRPTIHRDLPALAKDYDDVVIDGPPRVSDLARSAIIAADVVVIPIQPSPYDIWAADEVIKLIKEASVFKENIKAVFVINRKIVNTAIGRDVVEALEQYPFSVLKSAISQRVVFAESAATGNTVLEVDKNGSAAKEVKALVNELLKLGVE
>NZ_AP018173.1|WP_096595526.1|7928_8195_+|hypothetical-protein
MISEISLLFPTFYRLLNTLAIANSFRLQSKTKNDLEINKSENQGKKIVHNADQEIIDDPGSEAIFFGWTDDFFLVNFDYKLIPINKND
>NZ_AP018173.1|WP_096595525.1|7088_7274_-|hypothetical-protein
MEAKSQIRWKKIALPIVLGVIASCAVATAFRYWQAKTEGWCIRYYPDGKKEVLYGNECQSK
>NZ_AP018173.1|WP_096595524.1|6895_7087_+|hypothetical-protein
MKSESFVIALLVAILILVNALTILIAPIVRHCWAKYQHYRFIQKRRRQFYQELKILMSDRAIA
>NZ_AP018173.1|WP_096595523.1|6604_6826_+|hypothetical-protein
MNKPQKKRATNPRLKNKDVCMLLTIAKPQQSQLSNDYYDGQFDAAIGLSPKTYEGDYFKGYLDKVNESGVTPF
>NZ_AP018173.1|WP_096595522.1|4640_6494_-|hypothetical-protein
MSKAVQEQVNQLFEAVKDLKSLDEIKPYCESFNEWLNTSTNYSKASLGTVLSRAGFYKKFKSLPLEQGKNAESVSKHDAQGNVTGYELKHYALLLCGLDKKDWEERNETTRVSDRLMTADEDGNTGIEINPEEYLEVTGSLLASDNPHELAVGLIASTGRRPHEILARGKFTAVEEESYQLMFEGQGKKRGEKPVFKISTLFPASYVIERFYHLRKDASIKELLKQVSNEFPRDVAAQNKAIEDRRGNSLRRVVQEYYGGKDSKEPLLNFRHGQDQNDCKALRAACACLVTERDRPGSVGSKMFFYATFLGHITPGEKLSDRELSHIVTSLGYADYYVTKPVGFPDAPEKERDCNIKATLPDWEFVKQLQEDLELPNQKAVTAKLVERYKNSESIAQQLKEAQQEVAQLKAKVKQLEEFNNQLQATNNQLQQENAAMETTTQEPKTVTLNITELEAWLEKKVVEVVGKVAGSVAIPAITATPVKVAPPKEEIDWQTKTDAEVWGSKAPGASLEKIRRSYQAICLYNDTVATGDGDRLAITNQALRDLSGCNGLLVRDWIDQHKDEVISHNTKYGMENKKDPSNPASYANKGKDTDKILSLVNEEFLSGEGYRKAKSE
>NZ_AP018173.1|WP_096595532.1|15414_16377_-|hypothetical-protein
MVQSYCKDTAIQLIHGFSTGNIRDFIKMSTEQAEIEQPTETKQETPTGIFQAVGIVTGDVTFIKDDERNKYIANITIGQYQYNLLPLGSSRSKLASFNGLRKEIESTGISRQKLIVYPKVTHYPGREQQHRIAFQLVAFEPINVENSISKELNEFEFKLSGLWQFIPVCRTPCITVMKNFSDERLEYIKQAELASKVNFMKASHIPLIWKDTPVKPFRFNPKLEKEQQGKAMFVSIKARFIPGKDMFGFDSLLGMPQDEPPKYLKAGKKDKAEVLKSKLARKRQNTGNVTIKPKVIEKNQNQTGISSAAVVEKPKLKPKS
>NZ_AP018173.1|WP_096595533.1|16466_16682_+|hypothetical-protein
MDLLRHGIEHFGYANLYDCDGENGSYAYLLKDPKLFRQRFTIKGKQPIFWKPQDASEQRIFAAAWQLINKG
>NZ_AP018173.1|WP_096595534.1|16990_17392_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MPKTRVVFYQEEEGKVPVLEWLTRLLKEDRKGYANCVARIKQLAASGYELRRPVADYLSDGIYELRAKHIHVQYRILYFFHGQNVAILAHAITKEEAAVPPIDIERASARKLLFEKNPEAHTYVEEEDNGFDQ
>NZ_AP018173.1|WP_096595535.1|17375_17687_+|helix-turn-helix-transcriptional-regulator
MASTNDAIKIIDKLTSRDPELEAMVAEASINAEVAQLIYEARTSSGLTQKQLAELIGTKQPVIARLEDADYEGHSLSMLQKIAQALNQRVVIHLTPLSHEQSA
>NZ_AP018173.1|WP_096595536.1|17717_18641_-|ParB/RepB/Spo0J-family-partition-protein
MPPRKSNRVAPKLNTVDAFLSSSSNSSSTTAPIEKIRLPLKQPRRYFDPEKLAQLVQSVREHGILEPLLVRPLHDGEYELVAGERRLRAAREVGLGEIPIVSHELDDKQALQVALMENLQREDLNPVEETEAVLEILSLSLEIQPSEVVSILHQSFNAKQRGIELNQNVLIQLEQIETVLSQIGRFNAGTFRSSRIPLLNLPDDILSVLRQGEIEYTKAQAIARVKSEQLRSDLLKIAIAENLSLSEIKTKIKELTPETETTPDRVLAQRLAEISKRLQKNKGVSVQKNRTRILKLLDELEKLTSEN
>NZ_AP018173.1|WP_096595537.1|18640_19405_-|ParA-family-protein
MNAVSLKIISFFNQAGGTGKTTLTQNLGYQLAQQRHRVLLVDIDPQASLTAFMGLEPFELKQTIADSLLKDAPLPLHQNIHDVDLIPSNILLSAIEVQLHSVIAREWRLKQTLLTVQDSYDFVLIDCPPTLGIFSILSLVASTHVLIPIQTHFKAFLGVELLLDSIRQVRERINPGLAIAGVVPMMHESRTSQGKVILDGINEQLSPIAPIFPPIPRTISFADASMARQPLAVYDPKHPSVQILEAIAQKLEEV
>NZ_AP018173.1|WP_096595538.1|19751_20060_+|RNA-binding-protein
MSIYVGNLSYEVTENDLKGVFAEYGTVKRVQLPTDRETGRPRGFAFVEMGTDAEEEAAIEALDGADWMGRGLKVNKAKPREDRGSSGGNRGGYGGGGGRGRY
>NZ_AP018173.1|WP_096595539.1|20175_20364_+|30S-ribosomal-protein-S21
MTQIVVGDNEHIESALRRFKREVSKAGIFQDMRKHRHFETPIEKSKRKKLALHKQSKRRFRT
>NZ_AP018173.1|WP_096595540.1|20571_25485_-|tetratricopeptide-repeat-protein
MSNQHELENLAAENELSLQTLVRAITLSQGEFSLILLRCNYAAFRQDIVQRLHQLSPVKIREITLPVSVKTLYTSIYEKLGDEQPSALIVFGLESVKDIDTILTSANRVREEFRKNFPFPVLLLINDQVLQKLIRLATDFENWATIIHFAIATPDLVQFIKQTSEEVFAKVLDAGAGKFLDNSALNLEIGSPQRVELELAQAELQKRGVELDAELEASLEFVLGRDAVSMEQSRQHYERSLALARQSFNLEQEGCVLHNLGLWWRTYAIQHLAEQEAACLHAKDYYHKCLELFERANRPDLVAKFINTLGEVLQTLQQWDELEKVAQKALSLYQIYPDWFREARAYGFLAEVALADSAWNKAKQAAEKALSIVAINQSTQPNANLELVRYYHQGWYLFALARALQQLNKVQDALATLKAARRETKPQYDPELYIRILERLHNIYYQQGQYLAAFHIKQEKIQIEHQYGFRAFIGAAYLIPQHEVINPALFQAEKLVKVAQEIAVSGRQQDVNRLMNRMSRNDHKLTVFHGQSGVGKSSILNGGLVPALQLKSIDARDVLPIVIRVYTDWMGILAKCLVDNDTSSNSIEFICETLQNNTERNLLTVLIFDQFEEFFFVYTDQSKRQPFYKFLRLVLDIPFVKVILCLREDYLHYLLECDRLLNFTTINNNILDKNVRYYLGNFSSVDAKAVVQSLIEQTHFHLEPALIDKLVEDLADELGEVRPIELQIVGAQLQTDKITTLDQYLQLGTKEKLVERFLEEVIKDCGSENELCARVVLYLLTDDKGTRPFKTADNLAEDLKTADIVPEKEQLNLVLEILVGSGLVLKIPEDPADLYQLVHDYLVSFIRQSQQVRELEERKKEKEIRQQVEAELNHVLERQRNNAKRQRNWAIAGSAMMTFLAIVSVIFAFQAEYQRKQSEKNRIIAISKTSEALFTSQQTFDAFFEGIHAGILLKKLPSAQSDSQLRTQVVAALQQSFYWIVERDRLEGHQALIWGVTFSHDGKLIASTSYDHTIKLWNLDGSLYKTLEGHKDKVLGVSFSPDDRIIVSGDFKGIIRFWRRDGTFLKEINTHSKGVDDDKGVYSIDFSPDGQTIATGSRDGTLKLWKQDGTPLKTLKAHEYGVNSLAFSPDGKMIATGGRDSTLKLWTYNGNLLHTIKGYEDFVWDVAWSTDSQTIAAAAGSDHKIKLWNRDGTLLKDFKAHKDGINSVAFSPDGKMIATASDDKTIKLWKPDGTLLTTLSGHTNGVYSVRFSPDCKTLVSASADSTMKLWQVGSMICSRNAKIPTAGADSKMKIQIGSGVVSTLNAHSDQVNKVHFLLGEKIIVSASNDKTVKLSKLDGTLNKTFEGNNVSFSPNGQTIVTANDDNTVNLWKHGGKFLRTLFQNSDQIFDLNFSPNGKFIALGSRDNKVIILQPDSKKYQVLNKHHDWVKAVAWSPDSQMLASASDDNTVILWKQDNKGEFYRYETLTGDKGHNSWVLSVSFSPDGKMIATGSNDKTVILWRRDDKGKFSWDKKLIGHTGQVNGVSFSPKGDQIATASDDKTVKLWTHDGNLIKTLTGHSDRLLSAAFSDDGKTLALSSADGAIILWNLDELNHLNNLDSLLVRGCDWLHDYLKNNSTVNESDRHLCDDIKQKPSSQ
>NZ_AP018173.1|WP_096595541.1|25481_26777_-|AAA-family-ATPase
MKLDLLSFFQACNPSKTLVISKPEDKQYYIDFSKVRGAKIIEELGRTITRLAPEQATCQLFTGHIGCGKSTELLRLKAELEHQGFHVVYFESSQSLDMADVDVTDILLAVAREVSQSLEAIKINLKPGYFQTLFTELAEFLQMPIELGGELSVGIAKITAKTKDSPKLRVQLRQYLEPRTNGILESINKELLKPAREKLAQQGKKGLVVIVDNLDRVDNSFKSSGYYQPEYLFVERGEQLKQLNCHVVYTIPLVLIFSNALGRLTNRFGVDPKVLPMVPVKLNGSEFPQGMTLLKQMIMSRAFPGVSWEQSQHLITEVFDSPDTLERLCLVSGGHLRNLLMLLFRCLQQEDPPLSRECVNRVIKQRCNELTLAITADEWEVLREVAQQKSLRGHERYELLLRSMFVFEYRDEDGSWFDINPILAEAKEFWL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP018173_2	2.1\|14906\|36\|NZ_AP018173\|CRISPRCasFinder	14906-14941	36	NZ_AP018173.1	213661-213696	0	1.0

1. spacer 2.1|14906|36|NZ_AP018173|CRISPRCasFinder matches to position: 213661-213696, mismatch: 0, identity: 1.0

aaggtgaagaagtcgaatccgaattctcctcggaag	CRISPR spacer
aaggtgaagaagtcgaatccgaattctcctcggaag	Protospacer
************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP018173_1	1.1\|8866\|35\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	8866-8900	35	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	8866-8900	0	1.0
NZ_AP018173_1	1.2\|8937\|39\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	8937-8975	39	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	8937-8975	0	1.0
NZ_AP018173_1	1.2\|8937\|39\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	8937-8975	39	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9012-9050	0	1.0
NZ_AP018173_1	1.3\|9012\|39\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	9012-9050	39	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	8937-8975	0	1.0
NZ_AP018173_1	1.3\|9012\|39\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	9012-9050	39	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9012-9050	0	1.0
NZ_AP018173_1	1.4\|9087\|36\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	9087-9122	36	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9087-9122	0	1.0
NZ_AP018173_1	1.5\|9159\|41\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	9159-9199	41	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9159-9199	0	1.0
NZ_AP018173_1	1.6\|9236\|35\|NZ_AP018173\|PILER-CR,CRISPRCasFinder,CRT	9236-9270	35	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9236-9270	0	1.0
NZ_AP018173_1	1.7\|9307\|37\|NZ_AP018173\|CRISPRCasFinder,CRT	9307-9343	37	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9307-9343	0	1.0
NZ_AP018173_1	1.8\|9380\|36\|NZ_AP018173\|CRISPRCasFinder,CRT	9380-9415	36	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	9380-9415	0	1.0
NZ_AP018173_2	2.1\|14906\|36\|NZ_AP018173\|CRISPRCasFinder	14906-14941	36	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	14906-14941	0	1.0
NZ_AP018173_2	2.1\|14906\|36\|NZ_AP018173\|CRISPRCasFinder	14906-14941	36	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	213661-213696	0	1.0
NZ_AP018173_2	2.2\|14978\|36\|NZ_AP018173\|CRISPRCasFinder	14978-15013	36	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	14978-15013	0	1.0
NZ_AP018173_2	2.3\|15050\|35\|NZ_AP018173\|CRISPRCasFinder	15050-15084	35	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	15050-15084	0	1.0
NZ_AP018173_2	2.4\|15121\|37\|NZ_AP018173\|CRISPRCasFinder	15121-15157	37	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	15121-15157	0	1.0
NZ_AP018173_2	2.5\|15194\|31\|NZ_AP018173\|CRISPRCasFinder	15194-15224	31	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	15194-15224	0	1.0
NZ_AP018173_2	2.6\|15052\|32\|NZ_AP018173\|PILER-CR	15052-15083	32	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	15052-15083	0	1.0
NZ_AP018173_2	2.7\|15123\|34\|NZ_AP018173\|PILER-CR	15123-15156	34	NZ_AP018173	Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome	15123-15156	0	1.0
NZ_AP018173_2	2.5\|15194\|31\|NZ_AP018173\|CRISPRCasFinder	15194-15224	31	NZ_CP009067	Borreliella afzelii K78 plasmid lp38, complete sequence	16139-16169	7	0.774
NZ_AP018173_2	2.5\|15194\|31\|NZ_AP018173\|CRISPRCasFinder	15194-15224	31	NC_017237	Borreliella afzelii PKo plasmid lp38, complete sequence	14904-14934	7	0.774
NZ_AP018173_2	2.5\|15194\|31\|NZ_AP018173\|CRISPRCasFinder	15194-15224	31	NC_025153	Arcobacter butzleri strain AC1119 plasmid AB-1119-LD, complete sequence	10691-10721	7	0.774
NZ_AP018173_2	2.5\|15194\|31\|NZ_AP018173\|CRISPRCasFinder	15194-15224	31	MT774392	CrAssphage cr128_1, complete genome	67213-67243	8	0.742
NZ_AP018173_2	2.5\|15194\|31\|NZ_AP018173\|CRISPRCasFinder	15194-15224	31	MT375521	Pelagibacter phage Eistla EXVC0, complete genome	27242-27272	9	0.71
NZ_AP018173_1	1.7\|9307\|37\|NZ_AP018173\|CRISPRCasFinder,CRT	9307-9343	37	CP027480	Pseudomonas koreensis strain P19E3 plasmid p3, complete sequence	166690-166726	11	0.703

1. spacer 1.1|8866|35|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tttgaagatcaaaacctttaggaaaccgcgttttc	CRISPR spacer
tttgaagatcaaaacctttaggaaaccgcgttttc	Protospacer
***********************************

2. spacer 1.2|8937|39|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagagactcgtgcttcactccaaacaccttgaatatttg	CRISPR spacer
cagagactcgtgcttcactccaaacaccttgaatatttg	Protospacer
***************************************

3. spacer 1.2|8937|39|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagagactcgtgcttcactccaaacaccttgaatatttg	CRISPR spacer
cagagactcgtgcttcactccaaacaccttgaatatttg	Protospacer
***************************************

4. spacer 1.3|9012|39|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagagactcgtgcttcactccaaacaccttgaatatttg	CRISPR spacer
cagagactcgtgcttcactccaaacaccttgaatatttg	Protospacer
***************************************

5. spacer 1.3|9012|39|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagagactcgtgcttcactccaaacaccttgaatatttg	CRISPR spacer
cagagactcgtgcttcactccaaacaccttgaatatttg	Protospacer
***************************************

6. spacer 1.4|9087|36|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gctggggacacaccttgtgcagctgctccggcactt	CRISPR spacer
gctggggacacaccttgtgcagctgctccggcactt	Protospacer
************************************

7. spacer 1.5|9159|41|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagctatgctttgtcctatcaaaacaaaaacaaaaacaaaa	CRISPR spacer
cagctatgctttgtcctatcaaaacaaaaacaaaaacaaaa	Protospacer
*****************************************

8. spacer 1.6|9236|35|NZ_AP018173|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttcttctattgttcccttggcattaatcacattaa	CRISPR spacer
ttcttctattgttcccttggcattaatcacattaa	Protospacer
***********************************

9. spacer 1.7|9307|37|NZ_AP018173|CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aggagaatctcagccacaagcttatcgacctcccaag	CRISPR spacer
aggagaatctcagccacaagcttatcgacctcccaag	Protospacer
*************************************

10. spacer 1.8|9380|36|NZ_AP018173|CRISPRCasFinder,CRT matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ccgaaaccgtctcgcttggcttggatcatcgcaaga	CRISPR spacer
ccgaaaccgtctcgcttggcttggatcatcgcaaga	Protospacer
************************************

11. spacer 2.1|14906|36|NZ_AP018173|CRISPRCasFinder matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aaggtgaagaagtcgaatccgaattctcctcggaag	CRISPR spacer
aaggtgaagaagtcgaatccgaattctcctcggaag	Protospacer
************************************

12. spacer 2.1|14906|36|NZ_AP018173|CRISPRCasFinder matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aaggtgaagaagtcgaatccgaattctcctcggaag	CRISPR spacer
aaggtgaagaagtcgaatccgaattctcctcggaag	Protospacer
************************************

13. spacer 2.2|14978|36|NZ_AP018173|CRISPRCasFinder matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

atattattctgggggttaaccagcaagttatagtca	CRISPR spacer
atattattctgggggttaaccagcaagttatagtca	Protospacer
************************************

14. spacer 2.3|15050|35|NZ_AP018173|CRISPRCasFinder matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aaaaaataatcatagggaatgtatcatttatactt	CRISPR spacer
aaaaaataatcatagggaatgtatcatttatactt	Protospacer
***********************************

15. spacer 2.4|15121|37|NZ_AP018173|CRISPRCasFinder matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagtagatccagcttgtttgcttgtggaataggttga	CRISPR spacer
cagtagatccagcttgtttgcttgtggaataggttga	Protospacer
*************************************

16. spacer 2.5|15194|31|NZ_AP018173|CRISPRCasFinder matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cctatggttataaacatagcttctggttttc	CRISPR spacer
cctatggttataaacatagcttctggttttc	Protospacer
*******************************

17. spacer 2.6|15052|32|NZ_AP018173|PILER-CR matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aaaataatcatagggaatgtatcatttatact	CRISPR spacer
aaaataatcatagggaatgtatcatttatact	Protospacer
********************************

18. spacer 2.7|15123|34|NZ_AP018173|PILER-CR matches to NZ_AP018173 (Calothrix sp. NIES-2098 plasmid plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gtagatccagcttgtttgcttgtggaataggttg	CRISPR spacer
gtagatccagcttgtttgcttgtggaataggttg	Protospacer
**********************************

19. spacer 2.5|15194|31|NZ_AP018173|CRISPRCasFinder matches to NZ_CP009067 (Borreliella afzelii K78 plasmid lp38, complete sequence) position: , mismatch: 7, identity: 0.774

cctatggttataaacatagcttctggttttc	CRISPR spacer
tcaaagattataaaaatagcttcttgtttta	Protospacer
.* * *.******* ********* *****

20. spacer 2.5|15194|31|NZ_AP018173|CRISPRCasFinder matches to NC_017237 (Borreliella afzelii PKo plasmid lp38, complete sequence) position: , mismatch: 7, identity: 0.774

cctatggttataaacatagcttctggttttc	CRISPR spacer
tcaaagattataaaaatagcttcttgtttta	Protospacer
.* * *.******* ********* *****

21. spacer 2.5|15194|31|NZ_AP018173|CRISPRCasFinder matches to NC_025153 (Arcobacter butzleri strain AC1119 plasmid AB-1119-LD, complete sequence) position: , mismatch: 7, identity: 0.774

cctatggttataaacatagcttctggttttc	CRISPR spacer
cctatggttaaaaacatatcttcacttggtc	Protospacer
********** ******* ****   *  **

22. spacer 2.5|15194|31|NZ_AP018173|CRISPRCasFinder matches to MT774392 (CrAssphage cr128_1, complete genome) position: , mismatch: 8, identity: 0.742

cctatggttataaacatagcttctggttttc	CRISPR spacer
cctagggttataaacatagcctctgaaacag	Protospacer
**** ***************.****.  .

23. spacer 2.5|15194|31|NZ_AP018173|CRISPRCasFinder matches to MT375521 (Pelagibacter phage Eistla EXVC0, complete genome) position: , mismatch: 9, identity: 0.71

cctatggttataaacatagcttctggttttc	CRISPR spacer
gaaatggttagaagcatagcttctggtaaat	Protospacer
   ******* **.*************   .

24. spacer 1.7|9307|37|NZ_AP018173|CRISPRCasFinder,CRT matches to CP027480 (Pseudomonas koreensis strain P19E3 plasmid p3, complete sequence) position: , mismatch: 11, identity: 0.703

aggagaatctcagccacaagcttatcgacctcccaag	CRISPR spacer
tggaaaatctcagccacaagctaatcgaagagttcat	Protospacer
 ***.***************** *****    .. *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

43123 : 58003

uncultured_virus(33.33%)

transposase,integrase

attL 42597:42624|attR 58161:58188

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
42597:42624	attL	NA	NA	NA	NA
WP_096595839.1\|43123_43636_+\|transposase	transposase	NA	NA	NA	NA
WP_096595551.1\|44194_44374_+	hypothetical protein	NA	NA	NA	NA
WP_096595553.1\|44469_44787_-	DUF1192 family protein	NA	NA	NA	NA
WP_096595555.1\|45129_46026_+	SDR family oxidoreductase	A0A2N9QUX2	Trichoplusia_ni_ascovirus	9.3e-64	47.0
WP_096595557.1\|46561_47017_-\|transposase	transposase	A0A218MNH3	uncultured_virus	4.9e-21	35.3
WP_096595559.1\|47221_48361_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096595561.1\|48585_49317_-	hypothetical protein	A0A218MNH3	uncultured_virus	3.9e-28	37.9
WP_096595563.1\|49815_50010_-	hypothetical protein	NA	NA	NA	NA
WP_096595565.1\|50041_51070_+	dihydroorotase	NA	NA	NA	NA
WP_096595567.1\|51109_51376_-	hypothetical protein	NA	NA	NA	NA
WP_096595569.1\|52533_53466_-\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	3.0e-09	28.6
WP_096595571.1\|53378_53672_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_096595840.1\|54140_57218_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	6.8e-74	24.3
WP_096595573.1\|57233_57422_+	hypothetical protein	NA	NA	NA	NA
WP_096595575.1\|57418_58003_+\|integrase	tyrosine-type recombinase/integrase	A0A2L1IV36	Escherichia_phage	4.1e-36	42.7
58161:58188	attR	NA	NA	NA	NA

DBSCAN-SWA_2

96620 : 195661

Bacillus_phage(20.0%)

plate,tail,integrase,transposase,tRNA

attL 106841:106860|attR 178393:178409

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096595623.1\|96620_97760_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_096595625.1\|97779_98361_-	hypothetical protein	NA	NA	NA	NA
WP_096595627.1\|99119_99299_+	hypothetical protein	NA	NA	NA	NA
WP_096595629.1\|99347_99767_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_096595631.1\|100224_100482_-	WGR domain-containing protein	NA	NA	NA	NA
WP_096595633.1\|100644_101184_-	hypothetical protein	NA	NA	NA	NA
WP_096595635.1\|101180_101744_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_096595637.1\|101771_102293_-	hypothetical protein	NA	NA	NA	NA
WP_096595639.1\|102731_103397_-	hypothetical protein	NA	NA	NA	NA
WP_096595641.1\|103399_103864_-	hypothetical protein	NA	NA	NA	NA
WP_096595643.1\|103867_104893_-\|integrase	site-specific integrase	A0A1B1P7C7	Bacillus_phage	1.2e-11	26.4
WP_096595645.1\|105017_105353_-	XisI protein	NA	NA	NA	NA
WP_096595647.1\|105340_105757_-	fatty-acid oxidation protein subunit alpha	NA	NA	NA	NA
WP_096595649.1\|105795_106131_-	XisI protein	NA	NA	NA	NA
WP_096595651.1\|106118_106535_-	fatty-acid oxidation protein subunit alpha	NA	NA	NA	NA
106841:106860	attL	NA	NA	NA	NA
WP_096595653.1\|106915_107734_-	hypothetical protein	NA	NA	NA	NA
106841:106860	attL	NA	NA	NA	NA
WP_096595655.1\|107723_108851_-	AAA family ATPase	NA	NA	NA	NA
WP_096595657.1\|108841_110890_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_096595659.1\|112041_112533_-	hypothetical protein	NA	NA	NA	NA
WP_096595661.1\|112913_113726_-	TniQ family protein	NA	NA	NA	NA
112713:112732	attR	NA	NA	NA	NA
WP_096595663.1\|113715_114024_-	hypothetical protein	NA	NA	NA	NA
112713:112732	attR	NA	NA	NA	NA
WP_096595846.1\|114214_116014_-	maturase	A0A0U4J920	Pseudomonas_phage	1.0e-24	28.8
WP_096595665.1\|117954_119739_-	maturase	A0A0U4J920	Pseudomonas_phage	1.6e-27	29.9
WP_096595847.1\|120269_120863_-	retron-type reverse transcriptase	A0A0U4J920	Pseudomonas_phage	1.3e-29	46.9
WP_096595848.1\|121548_121914_-	AAA family ATPase	NA	NA	NA	NA
WP_096595667.1\|122327_122906_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_096595669.1\|122918_123584_+	hypothetical protein	NA	NA	NA	NA
WP_096595671.1\|123715_124972_+\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	2.6e-40	36.6
WP_096595673.1\|125033_126254_+\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.4e-30	33.7
WP_096595675.1\|126274_126709_+\|tail	phage tail protein	T2KSM5	uncultured_phage	1.7e-10	34.7
WP_096595676.1\|126731_127094_+	hypothetical protein	NA	NA	NA	NA
WP_096595677.1\|127353_127794_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096595679.1\|127821_131445_+	hypothetical protein	NA	NA	NA	NA
WP_096595681.1\|131435_132095_+	peptidoglycan-binding protein	NA	NA	NA	NA
WP_096595683.1\|132098_133178_+	phage late control D family protein	NA	NA	NA	NA
WP_096595685.1\|133174_133789_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096595849.1\|133884_134238_+	hypothetical protein	NA	NA	NA	NA
WP_096595687.1\|134252_134651_+	GPW/gp25 family protein	A0A1D8KR06	Synechococcus_phage	4.6e-07	30.5
WP_096595689.1\|134655_137991_+\|plate	putative baseplate assembly protein	A0A1D7SFA7	Cyanophage	5.6e-05	34.1
WP_096595691.1\|137993_138977_+\|plate	baseplate protein J	NA	NA	NA	NA
WP_096595693.1\|138991_139822_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096595695.1\|139848_142065_+	hypothetical protein	R4TVM2	Phaeocystis_globosa_virus	1.3e-05	26.3
WP_096595697.1\|142310_144485_+	ATP-binding protein	A0A0R6PCP6	Moraxella_phage	1.3e-34	38.1
WP_096589255.1\|146113_147499_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.9e-146	58.2
WP_096595699.1\|148044_148833_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_096595559.1\|149057_150197_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096595701.1\|150566_151148_+	hypothetical protein	NA	NA	NA	NA
WP_096595703.1\|152153_153734_+	B12-binding domain-containing radical SAM protein	A0A0M4R1U9	Streptomyces_phage	4.0e-09	24.2
WP_096595705.1\|153973_154300_-	hypothetical protein	NA	NA	NA	NA
WP_096595707.1\|154683_154884_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_096595708.1\|154950_155130_-	hypothetical protein	NA	NA	NA	NA
WP_096595709.1\|155129_155456_-	hypothetical protein	NA	NA	NA	NA
WP_096595711.1\|156054_156375_+	hypothetical protein	NA	NA	NA	NA
WP_096595713.1\|156438_156624_+	hypothetical protein	NA	NA	NA	NA
WP_096595715.1\|156666_157071_+	hypothetical protein	NA	NA	NA	NA
WP_096595717.1\|158439_159357_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096595719.1\|159381_160722_-	AAA domain-containing protein	NA	NA	NA	NA
WP_096595721.1\|161011_161197_+	hypothetical protein	NA	NA	NA	NA
WP_096595723.1\|161516_161930_-\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_096595850.1\|162042_163128_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_096595725.1\|163300_163822_-	DUF3122 domain-containing protein	NA	NA	NA	NA
WP_096595727.1\|163833_164058_-	hypothetical protein	NA	NA	NA	NA
WP_096595559.1\|164752_165892_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096595729.1\|166897_167389_+	hypothetical protein	NA	NA	NA	NA
WP_096595731.1\|167577_168666_+\|integrase	tyrosine-type recombinase/integrase	S5MBZ0	Brevibacillus_phage	1.2e-12	30.5
WP_096595733.1\|168666_169089_+	hypothetical protein	NA	NA	NA	NA
WP_096595735.1\|169019_170591_+\|integrase	tyrosine-type recombinase/integrase	A0A2I7SCV1	Paenibacillus_phage	2.0e-05	23.5
WP_096595737.1\|170580_171492_+	hypothetical protein	NA	NA	NA	NA
WP_096595851.1\|172290_172524_+	hypothetical protein	NA	NA	NA	NA
WP_096595738.1\|172647_173907_+	hypothetical protein	NA	NA	NA	NA
WP_096595739.1\|173909_175025_+	DUF3800 domain-containing protein	NA	NA	NA	NA
WP_096595741.1\|175173_175533_-	hypothetical protein	NA	NA	NA	NA
WP_096595743.1\|175694_176048_-	hypothetical protein	NA	NA	NA	NA
WP_096595745.1\|176238_176883_-	glutathione S-transferase	NA	NA	NA	NA
WP_096595747.1\|176885_177374_-	DUF4174 domain-containing protein	NA	NA	NA	NA
WP_096595749.1\|177631_178366_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	NA	NA	NA	NA
WP_096595751.1\|178507_179005_+	hypothetical protein	NA	NA	NA	NA
WP_096595753.1\|179162_179672_-	HAD family hydrolase	NA	NA	NA	NA
WP_096595755.1\|179717_181187_-	DNA-protecting protein DprA	NA	NA	NA	NA
WP_096595757.1\|181192_181468_-	phosphoribosyltransferase	NA	NA	NA	NA
WP_096595852.1\|181663_182681_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_096595759.1\|182678_183074_+	hypothetical protein	NA	NA	NA	NA
WP_096595761.1\|183144_183393_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_096595763.1\|183455_185468_+	ATP-binding protein	NA	NA	NA	NA
WP_096595765.1\|185482_186817_+	NurA domain-containing protein	NA	NA	NA	NA
WP_096595767.1\|186843_187299_+	hypothetical protein	NA	NA	NA	NA
WP_096595768.1\|187509_187749_+	hypothetical protein	NA	NA	NA	NA
WP_096595770.1\|187785_188136_+\|transposase	transposase	NA	NA	NA	NA
WP_096595772.1\|189130_189352_-	aldo/keto reductase	NA	NA	NA	NA
WP_096595774.1\|189418_190312_+\|transposase	transposase	NA	NA	NA	NA
WP_096595776.1\|190417_191269_-	aldo/keto reductase	NA	NA	NA	NA
WP_096595778.1\|191461_192427_-	aldo/keto reductase	NA	NA	NA	NA
WP_096595853.1\|192878_193730_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_096595780.1\|193969_194182_+	hypothetical protein	NA	NA	NA	NA
WP_096595782.1\|194325_194847_+	hypothetical protein	NA	NA	NA	NA
WP_096595784.1\|194940_195132_+	hypothetical protein	NA	NA	NA	NA
WP_096588143.1\|195094_195661_-\|transposase	IS630 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_AP018172

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP018172_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_1

744885-746239

TypeIII

Consensus_repeat	Method
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	PILER-CR
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CRISPRCasFinder
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CRT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	PILER-CR

18 spacers

cas10,csm3gr7,csx10gr5,csm2gr11,PD-DExK,csx19,csx21

The CRISPR arrays of NZ_AP018172_1

>merge|NZ_AP018172|1|744885-746239|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACAAGGTTTTTGCCCTATCGGTCGCGCGTCGCTCCGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACACTTGTCAAATGTCCATTCCTGAACTTCATCAGAAAAAGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACCAAATCTCGCGTTGGCGGGTACGATCACACTAATATGGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACCTACTGCTGAAGCGATTGGAGCTAATGCACTAAAAGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTGTATTGAATGCCCATTGCCAGTTGACCGATATATTAACGCCAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTTACTTGCTACTTTGTTTTAGATATGACTCATAATCGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACATAGAAGAGTAGTATGCTTCCAATTGATTACGATAGCTAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTTTTCTGTAAAAGAACAAACTAAAGATAAAGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTAGGACAAGCGTTAGATGATCTTAATAAGGCAGCTAAAGGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACGTTTAAAGGTGAGGCTTGTTCTCAGGCATTTTGGGAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTTATTTCCTGAATCAAAACTTGATTACCTTTGTATGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACGCTCAGGATGGGAGCGTAGCTAACCACTTAGCCCAGTTACGCTTACACTTACCCCGCAAGGGGATGGAAACTTCATCAGTAGGTGCAGATGCACTATTAATCCAAAGTAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTTCACAATACTGCTACGTTTAAAACCATCGTTACCTTGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACATTAATTGAGAACACTGGTATTGATTCGATGCTAACTGTTACGCTTACACTTCCCCCGTAAGGGGATGGAAACAATATTTTCTCTATCACTCTAGAGTTGAATCGGATACCAGAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACGTTTGAAAGTTAAAACTTCCTGTTGGATGTTGTTCAAAACGTTACGCTTACACTTCCCCCGTAAGGGGATGGAAACTCCGCTGGCTAATCCATTTCACCCAAGGGGTCAAGAAGTTACGCTTACACTTTCCCCGCAAGGGGATGGAAAC

>NZ_AP018172|1|1|744885-745361|PILER-CR
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	AAGGTTTTTGCCCTATCGGTCGCGCGTCGCTCC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ACTTGTCAAATGTCCATTCCTGAACTTCATCAGAAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CAAATCTCGCGTTGGCGGGTACGATCACACTAATATGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CTACTGCTGAAGCGATTGGAGCTAATGCACTAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TGTATTGAATGCCCATTGCCAGTTGACCGATATATTAACGCCA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTACTTGCTACTTTGTTTTAGATATGACTCATAATC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACATAGAAGAGTAGTATGCTTCCAATTGATTACGATAGCTAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTTTTCTGTAAAAGAACAAACTAAAGATAAAGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TAGGACAAGCGTTAGATGATCTTAATAAGGCAGCTAAAGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTAAAGGTGAGGCTTGTTCTCAGGCATTTTGGGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTATTTCCTGAATCAAAACTTGATTACCTTTGTAT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GCTCAGGATGGGAGCGTAGCTAACCACTTAGCCCA
GTTACGCTTACACTTACCCCGCAAGGGGATGGAAAC	TTCATCAGTAGGTGCAGATGCACTATTAATCCAAAGTA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTCACAATACTGCTACGTTTAAAACCATCGTTACCTT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ATTAATTGAGAACACTGGTATTGATTCGATGCTAACT
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC	AATATTTTCTCTATCACTCTAGAGTTGAATCGGATACCAGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTGAAAGTTAAAACTTCCTGTTGGATGTTGTTCAAAAC


>NZ_AP018172|1|1|744885-746239|CRISPRCasFinder
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	AAGGTTTTTGCCCTATCGGTCGCGCGTCGCTCC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ACTTGTCAAATGTCCATTCCTGAACTTCATCAGAAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CAAATCTCGCGTTGGCGGGTACGATCACACTAATATGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CTACTGCTGAAGCGATTGGAGCTAATGCACTAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TGTATTGAATGCCCATTGCCAGTTGACCGATATATTAACGCCA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTACTTGCTACTTTGTTTTAGATATGACTCATAATC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ATAGAAGAGTAGTATGCTTCCAATTGATTACGATAGCTA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTTTCTGTAAAAGAACAAACTAAAGATAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TAGGACAAGCGTTAGATGATCTTAATAAGGCAGCTAAAGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTAAAGGTGAGGCTTGTTCTCAGGCATTTTGGGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTATTTCCTGAATCAAAACTTGATTACCTTTGTAT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GCTCAGGATGGGAGCGTAGCTAACCACTTAGCCCA
GTTACGCTTACACTTACCCCGCAAGGGGATGGAAAC	TTCATCAGTAGGTGCAGATGCACTATTAATCCAAAGTA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTCACAATACTGCTACGTTTAAAACCATCGTTACCTT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ATTAATTGAGAACACTGGTATTGATTCGATGCTAACT
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC	AATATTTTCTCTATCACTCTAGAGTTGAATCGGATACCAGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTGAAAGTTAAAACTTCCTGTTGGATGTTGTTCAAAAC
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC	TCCGCTGGCTAATCCATTTCACCCAAGGGGTCAAGAA
GTTACGCTTACACTTTCCCCGCAAGGGGATGGAAAC

>NZ_AP018172|1|1|744885-746239|CRT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	AAGGTTTTTGCCCTATCGGTCGCGCGTCGCTCC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ACTTGTCAAATGTCCATTCCTGAACTTCATCAGAAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CAAATCTCGCGTTGGCGGGTACGATCACACTAATATGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CTACTGCTGAAGCGATTGGAGCTAATGCACTAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TGTATTGAATGCCCATTGCCAGTTGACCGATATATTAACGCCA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTACTTGCTACTTTGTTTTAGATATGACTCATAATC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ATAGAAGAGTAGTATGCTTCCAATTGATTACGATAGCTA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTTTCTGTAAAAGAACAAACTAAAGATAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TAGGACAAGCGTTAGATGATCTTAATAAGGCAGCTAAAGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTAAAGGTGAGGCTTGTTCTCAGGCATTTTGGGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTATTTCCTGAATCAAAACTTGATTACCTTTGTAT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GCTCAGGATGGGAGCGTAGCTAACCACTTAGCCCA
GTTACGCTTACACTTACCCCGCAAGGGGATGGAAAC	TTCATCAGTAGGTGCAGATGCACTATTAATCCAAAGTA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTCACAATACTGCTACGTTTAAAACCATCGTTACCTT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ATTAATTGAGAACACTGGTATTGATTCGATGCTAACT
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC	AATATTTTCTCTATCACTCTAGAGTTGAATCGGATACCAGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTGAAAGTTAAAACTTCCTGTTGGATGTTGTTCAAAAC
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC	TCCGCTGGCTAATCCATTTCACCCAAGGGGTCAAGAA
GTTACGCTTACACTTTCCCCGCAAGGGGATGGAAAC

>NZ_AP018172|1|2|745468-746166|PILER-CR
	AAGGTTTTTGCCCTATCGGTCGCGCGTCGCTCC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ACTTGTCAAATGTCCATTCCTGAACTTCATCAGAAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CAAATCTCGCGTTGGCGGGTACGATCACACTAATATGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	CTACTGCTGAAGCGATTGGAGCTAATGCACTAAAAG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TGTATTGAATGCCCATTGCCAGTTGACCGATATATTAACGCCA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTACTTGCTACTTTGTTTTAGATATGACTCATAATC
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACATAGAAGAGTAGTATGCTTCCAATTGATTACGATAGCTAGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAACTTTTCTGTAAAAGAACAAACTAAAGATAAAGGTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TAGGACAAGCGTTAGATGATCTTAATAAGGCAGCTAAAGG
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTAAAGGTGAGGCTTGTTCTCAGGCATTTTGGGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTATTTCCTGAATCAAAACTTGATTACCTTTGTAT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GCTCAGGATGGGAGCGTAGCTAACCACTTAGCCCA
GTTACGCTTACACTTACCCCGCAAGGGGATGGAAAC	TTCATCAGTAGGTGCAGATGCACTATTAATCCAAAGTA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	TTCACAATACTGCTACGTTTAAAACCATCGTTACCTT
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	ATTAATTGAGAACACTGGTATTGATTCGATGCTAACT
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC	AATATTTTCTCTATCACTCTAGAGTTGAATCGGATACCAGA
GTTACGCTTACACTTCCCCCGCAAGGGGATGGAAAC	GTTTGAAAGTTAAAACTTCCTGTTGGATGTTGTTCAAAAC
GTTACGCTTACACTTCCCCCGTAAGGGGATGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096595108.1\|753949_755302_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224001
NZ_AP018172.1\|WP_096586999.1\|747417_747654_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096586998.1\|746839_747151_+\|transcriptional-regulator	unknown	unknown	unknown
NZ_AP018172.1\|WP_096586992.1\|737983_738604_-\|hypothetical-protein	PD-DExK	mkCas0061_PD-DExK_CAS-I:CAS-III	unknown
NZ_AP018172.1\|WP_096586994.1\|739507_739921_-\|hypothetical-protein	csm2gr11	mkCas0063_csm2gr11_CAS-III-D	unknown
NZ_AP018172.1\|WP_017653080.1\|751648_751867_+\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NZ_AP018172.1\|WP_096595107.1\|749805_751005_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_AP018172.1\|WP_096587003.1\|752294_753095_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224637
NZ_AP018172.1\|WP_096586993.1\|738614_739502_-\|CRISPR-associated-RAMP-protein	csm3gr7	cd09683_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187814
NZ_AP018172.1\|WP_096586995.1\|739917_741204_-\|CRISPR-associated-RAMP-protein-Csx10	csx10gr5	cd09700_csx10gr5_CAS-III-D	gnl\|CDD\|131722
NZ_AP018172.1\|WP_096587001.1\|749290_749605_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096586988.1\|734943_735384_-\|hypothetical-protein	csx21	mkCas0116_csx21_CAS-III-A:CAS-III-D	unknown
NZ_AP018172.1\|WP_096586991.1\|736984_737953_-\|CRISPR-associated-protein	csm3gr7	COG1337_csm3gr7_CAS-III-D	gnl\|CDD\|224256
NZ_AP018172.1\|WP_096586997.1\|741919_744307_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl\|CDD\|274208
NZ_AP018172.1\|WP_096587004.1\|753224_753809_-\|DUF3455-domain-containing-protein	unknown	unknown	gnl\|CDD\|314761
NZ_AP018172.1\|WP_096586996.1\|741200_741923_-\|CRISPR-associated-protein-Csm3	csm3gr7	COG1337_csm3gr7_CAS-III-D	gnl\|CDD\|224256
NZ_AP018172.1\|WP_096587002.1\|751428_751656_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_AP018172.1\|WP_096586990.1\|736517_736997_-\|hypothetical-protein	csx19	cls000059_csx19_CAS-III-D	unknown
NZ_AP018172.1\|WP_096587000.1\|747979_749296_+\|FADH(2)-oxidizing-methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))--methyltransferase-TrmFO	unknown	unknown	gnl\|CDD\|235416
NZ_AP018172.1\|WP_096586989.1\|735383_736466_-\|CRISPR-associated-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096595108.1\|753949_755302_-\|hypothetical-protein	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	6.21409e-05
NZ_AP018172.1\|WP_017653080.1\|751648_751867_+\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	3.83979e-10
NZ_AP018172.1\|WP_096595107.1\|749805_751005_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.41968e-51
NZ_AP018172.1\|WP_096587003.1\|752294_753095_-\|hypothetical-protein	gnl\|CDD\|224637	COG1723, COG1723, Uncharacterized conserved protein [Function unknown].	6.94455e-99
NZ_AP018172.1\|WP_096586993.1\|738614_739502_-\|CRISPR-associated-RAMP-protein	gnl\|CDD\|187814	cd09683, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.16712e-87
NZ_AP018172.1\|WP_096586995.1\|739917_741204_-\|CRISPR-associated-RAMP-protein-Csx10	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	1.04569e-147
NZ_AP018172.1\|WP_096587002.1\|751428_751656_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	2.09537e-07
NZ_AP018172.1\|WP_096586991.1\|736984_737953_-\|CRISPR-associated-protein	gnl\|CDD\|224256	COG1337, COG1337, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	7.05227e-47
NZ_AP018172.1\|WP_096586997.1\|741919_744307_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	1.55639e-63
NZ_AP018172.1\|WP_096587004.1\|753224_753809_-\|DUF3455-domain-containing-protein	gnl\|CDD\|314761	pfam11937, DUF3455, Protein of unknown function (DUF3455). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.	2.95002e-42
NZ_AP018172.1\|WP_096586996.1\|741200_741923_-\|CRISPR-associated-protein-Csm3	gnl\|CDD\|224256	COG1337, COG1337, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.45058e-40
NZ_AP018172.1\|WP_096587000.1\|747979_749296_+\|FADH(2)-oxidizing-methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))--methyltransferase-TrmFO	gnl\|CDD\|235416	PRK05335, PRK05335, tRNA (uracil-5-)-methyltransferase Gid; Reviewed.	0
NZ_AP018172.1\|WP_096586989.1\|735383_736466_-\|CRISPR-associated-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.84675e-19

>NZ_AP018172.1|WP_096586997.1|741919_744307_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MNDSRKRIITAIAWCLAWGDKEQLDADELSQLQQMRQAISMGKEEPAQLKSFVDQARRLYEIPEKYFPETLQKLQQDYSDLWEQQTPIGLVYGGATKIKQYVFEAAKLPDIRGASALLDRINLVDLPAFFGGEVAKSVTVERWLDDNQFADLRKALIPELIIYSTGGSILAFCPAAFVDKLANAIEKRYTHETLTANSCAVGDTFRLLELRFGLLKNPIEKTLWLEEYLEKQDKAIIKAYFDLPDVTDPKEKFRDRKNFSELVGKLANLFNQRRNGNDLPGDKRPSRCYPPMFETHPYIQRDESDRRSLIARVTELPNNPRFSEALARKRIVGDIGKLGRFKDNSQWFTNLNLGWQPIGIRIPSWCNEFEEFLQKPENKLLADSYIAEYQKFLTQQQNGQIIDNNKTIYSKPEEARSLREIGNASSPAGFVAYIYADGNNMGGYIRKQIKTPQQYREFSNDILDATQQSVYKALAKHLQAHRLNHLTDPDNENRNERWIHPFEIITIGGDDVLLIVPADKALAVAKTIGDEFENLLLEKGDRYQLETLGEKPYNPKLVHRYQKQLPETQQCKLSMSTGLLITAEDTPIYYAEKLTSQLLKSAKKRAKDLKRDYNYYGGTVDFLVMKAVTMISSNIEEFRQQGLTKAKTGLPKLKLYASPYTLHELGGLLETVKALKKVEFPRSQLYQVRSLLERGKNTAILNYRYFRVRLKQGQDELKTVFEDAWCQPKNPQNTGNLAPWMSLKEHTEDSENQDKMTYETIWRELVDLYPFIAEEKDENQGNQGTGKKDERRVGA
>NZ_AP018172.1|WP_096586996.1|741200_741923_-|CRISPR-associated-protein-Csm3
MIHLDRLSQVQPETISLTAVIDTALCVGAGGSSGSLADKPIVRNAQKQLIIPASQLKGRLRHECEKLARGLGWQIFESPAAETLSPLEVNEDRSHLRQDYTVEGYRGYHCLVSQIFGDPFLPSRVIVDDLICKVPEEELPEVLRPGVTINRKRRTAEERKLYLLETSPANAQLEFEGEIHLLKPNCPEYAKPLILAALHHIHALGGSKSAGLGWLTWKDLPQMSATDAAWLGLKAKKANL
>NZ_AP018172.1|WP_096586995.1|739917_741204_-|CRISPR-associated-RAMP-protein-Csx10
MKRIELNIKVRSPLALGTQKPGGSVNEVEEYIPGVVIRGAIASQILQKSHQQFANLEQNGGEFQTLFLGDRSAIFQNAYPAIAKDGDDYKFVTNEIQVLPATAVSSKTNPGFKPKHGVFDTLIDWFWSEQYHQPYDPSSVGALDEKTDARVETYSGFYSQENGKYYSHSASSRFLTRVGINRRRATSAEDILYSIAVLNESFPKNRKSSVVEWEDFVYRSYVVVEDDTLADKLATFINNNSQIFRLGGSISRGLGKVEIQAKPVKYIDDISTRINKFNQAIKNRLQDWQEAFGKLENNPLENKTYFTLDLQSDAILTEDWRRTTVISANMLKEIAGIDAEVDDNLKLHVAYSSYDYRSGWNAAWGLMKDVELVTNQGAVYLFSTTQPQPWLEALAKLEQRGIGDRTCEGYGQVQVCHEFHQVFWENAV
>NZ_AP018172.1|WP_096586994.1|739507_739921_-|hypothetical-protein
MSDWSEQKKELKIQQGIRQAEDDLVIAIQKALDNSKYGELEESQFRNLVRVSDTTESTEVIKNFIRYQVGRDEKWGKGKESLAEQIIQDIDNLINNLSKKIAQEAKSENLNHILLELTRRYLGYGSRYLVYKRKGQS
>NZ_AP018172.1|WP_096586993.1|738614_739502_-|CRISPR-associated-RAMP-protein
MFDVFRNRLEITGTLTTVTALRISAGRSTEPIGADLPVIKDALGRPLIPGASFKGALRSRLESFLRGIDPKFAANPALESEWSIPPDRMSEFKNSINNLANQAKEEQLHQFILDRTDLVSFLFGSPWLASKFQVRDLTVLPDSWFGQYQERDGVAIERDTETAGDGKLYDFQVVPAGTPFEFRAVVENAEPHELGLLMIGLHQFETEQIPLGGGRSRGLGVVKLDINKMWWFEYPDNNPEQLLIYLQRLVNGEKDHYKCNQEQLESHKQNWTKALIDYLRANINHSSPTATEQIT
>NZ_AP018172.1|WP_096586992.1|737983_738604_-|hypothetical-protein
MAFSNYKTIGEVLKAFQVIYTEANFIGEVAFNIADYFREDLETMMRDGVVDNSEFAICENLIYPVLKEVWKLYRTKFILWSHQSLNYDEKLSGFPEYILAKKSPLGKVVFDKPYFILVEAKQDNFETGWSQCLAEMIAAQRLNGELQIVIFGIVSNGVTWQFGKLESDTFTRNILPYSIYELEKLFAAVNYVFQQCELQLNTLIAA
>NZ_AP018172.1|WP_096586991.1|736984_737953_-|CRISPR-associated-protein
MHKRLVNHCIIELSLIPDGPILIKSGKEGADPTKPQMEFVETYHTGGRSIYLPGSSLKGAIRAHAERIVRTVGSDSRNDAKLWASNPLKQNEYEYLKNQNLTPPQIYQQSSFTDQIFGSTEIASRLRIEDAYPDKSQPLKIEERNGVAIDRVFGSVAVGPFDYQVCTSGEFRTKIHLKNFCLAQLGLIGLVLRDLNDGWFAIGFAKSRGLGSVKVQYHSATIQYPGCELQDKRIHQFGTQQSWPHTSLLGAGEFLRTENANPYGFPIPDEQQTPIAAEEMAFGFGVQLSWVGDSETGVKDLFMRAVRAWSELVRQGGTACAS
>NZ_AP018172.1|WP_096586990.1|736517_736997_-|hypothetical-protein
MCFVGVHQKSATELIKLLEKLSTPDSCYFLRWTNRVSGFWRRRSEIESLKEDICDRLLNHPSQQFPSPEGQLFNHHLELRWKKQGELYKVLLLTTLKLEPGFEPVGENWEVLDRNAHQYSATDSRFPQGFTSDDVKIAQRYFRDSTTATVHFVALTIPK
>NZ_AP018172.1|WP_096586989.1|735383_736466_-|CRISPR-associated-protein
MTRTPSNPSQQAISPKPYKLVALPSQPPNRQRPAGQERFRQDRLSGKISLRLTVQTNTVVASGAIALGIDILGLNKNSPDLIKTAVRRDRRLIIPGSSFKGVVRSAYEAITQSCLCKVTPETKRQNWVPDKYQECQINQAKNRIEICPACQVFGAMNWQGLIRFTDAICETTKFRVKFIPSLYQPQPEPYNKITKQKHLNSEYFGNHGKVRGRKFYYHALQAIEGGNRGIETQQAGNQYTFTTDLYFMNLSAAELGTLLIVLGQDTPKHPIALKVGSGKPIGMGTMTVDVTAIEQPTNMCDRYLSFQPETNQLTGEKLENFKRNAIKKAHETKLVQPEQLQQLTEILKYPTNRQAPEGMY
>NZ_AP018172.1|WP_096586988.1|734943_735384_-|hypothetical-protein
MAIPNNLQDEHWKVAHEIAQSLVLDKTDVNELDKAIAYLRANSEQPKAGAKFFKYLSILVKNGEYISHSNKTVEYYESIAAACQQLQPYKHDALLMIQILGWTKRLMRYYRKVGVPDLQGDRSIDVKSVQALARPKNTERPQPHRK
>NZ_AP018172.1|WP_096586998.1|746839_747151_+|transcriptional-regulator
MKTKPFSELRKRMTPEQRAESDTRAKLALLHITLMELQESLGLSQDDLEKDLNAISSSMSELENQEDIQVATLSRYIKALGGTLKLVAQFPDEEKEIVLAQFE
>NZ_AP018172.1|WP_096586999.1|747417_747654_+|hypothetical-protein
MAIEYSETANVVCGIAIVVSKMAIEYSETAIDDSKIAIVVCGIANVVSKTANVVYEIATEYSKMAIVAPEIVIAAAIH
>NZ_AP018172.1|WP_096587000.1|747979_749296_+|FADH(2)-oxidizing-methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))--methyltransferase-TrmFO
MTQQPIHVIGGGLAGTEAAWQIAQAGVPVILHEMRPNRFSPAHHTEHLAELVCSNSFGAMASDRATGLLHEELRQLNSIIIAKADEHAVPAGGALAVDRGQFSQELTETLSHHPLIEFRRGEVPAIPEGIVVLATGPLTSPDLAEDIRRLTGMEYLSFFDAASPIVVGESINRDIAFMASRYDKGEAAYLNCPMNKEQYLHFWEELKKAEQTELKDFERETAKFFEACLPIEEQALRGEDTMRYGPLKPVGLSDSRTGERPYAVVQLRQEDKAGQLWNMVGFQTNLRWGEQKRVFRLIPGLENAEFVRLGVMHRNTFINAPQLMHPTLQFKQRPNLLAAGQLIGTEGYTAAAAGGCLAGINAARLALGKEALTLPPTTMMGALFEFISSASPKHFQPMPPNFGIFPELGVKIKNKQERYGRYRDRSLADLANWKANQL
>NZ_AP018172.1|WP_096587001.1|749290_749605_-|hypothetical-protein
MNIRKAILLITLVIPGLAVVGISLYWFILDYDALGKAENYIEKLAKDEKVNDRQLDYAYHRTLAHRINVFADGTWGLIGGVITGLGIHGLATIPEQHKSKSDKS
>NZ_AP018172.1|WP_096595107.1|749805_751005_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MRAPFFAKQRFGWWNLVISWFLCIIFLLIIPALPVQAATTPSIDTLKQQQQQVKQQRQSVVKERDRLNNLQNAAQNRLTGIKQNLKTTDSHIQHSELQLKLAAERLQKLEADLAVAERSYEERQVATVARLRFLQRSPTSQGWGVLLQSENISDFISRRHQLKLVYQADQQILVKLNQQANSIVQQKTAVEQQKNEVALIREQLLAQKADYQAQAQLQSEVIQRLNSDRLALEAAQNQLEQDSKNLEALIQQKIAEAQAKTNSSSKNIIIRGTGMLALPSDAPTSSPFGWRVHPILGYRRFHAGLDFAASYGSTIRAADSGTVIFAGWYGGYGKAVIIDHGSGITTLYGHTSELYVSEGQGVQRGQAIAAVGSTGLSTGPHLHFEVRRDGTPIDPANYL
>NZ_AP018172.1|WP_096587002.1|751428_751656_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MPKKIRELKQWLRQVGFTELSGKGSHTNWIHPLYAGKLTVSGKDSSDAKPYQEKEVQQAIKEVEEKQQQEKQEDE
>NZ_AP018172.1|WP_017653080.1|751648_751867_+|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MSKFKYQMLIQWSVEDNCFLVGFPDFPGQRWRTHGDTYEEAVANGIEALESLIMAYEATNEPLPQPTVYQVA
>NZ_AP018172.1|WP_096587003.1|752294_753095_-|hypothetical-protein
MQKLLFNHRDSFKAQALFLGKKINLQTLENYVCLATMPLMVKVGEQGCAVLLGYGAVVLFNLEPVEKAAFLTEISSQVSGSFANPEMEEVEVHLNMAESERVKEGKIFLHEFSIERLQIVADILAKSAVLSHYETSLATVFDQIEPFAASLQSEHRSKRKSRELLSQLGTTLLVQHKIVGRVEIIDKPELLWESPQLETLYLRLEDEYEIRERHNALERKLELISQTAQTVLEFMQHSSSQRVEWYVVILIVVEILLSLYDIIFKG
>NZ_AP018172.1|WP_096587004.1|753224_753809_-|DUF3455-domain-containing-protein
MNKTYFLNISLLLVLLGLSAGNTHAQTTSSTATDVPKTLQVPTDQSLLFKASAKGSQIYVCKLKPENLDAFEWTLKAPDAVLFNEQGQSLGKHYAGPTWESNDGSKVIGQVKAKADAPQTSTIPWLLLQGRSHQGNGIFSQVNWIQRLHTVGGKAPNQGCDRAHANREVKVSYQADYYFWGVPSNKSVNRQTNP
>NZ_AP018172.1|WP_096595108.1|753949_755302_-|hypothetical-protein
MVSDSKRNPIVLIHGYSASGESFKVWEQRLEARGYDVSTIHICSYVTLTNEVTIKDIAEGFDRALSIDGGLAPDEEFDAIVHSTGMLVIRSWLTTYSSKRRNRLKHLIGLAPATFGSPLAHKGRSWLGAMFKGNKEFGPDFLEAGDRVLDGLELGSRFTWDLAHKDLLSSEVFYGTKTDTPYVFTFCGTNPYSGIAKFISDPGTDGTVRWAGCALNTRKIVLDLTKQPEQGQRIDFDGSSNDGIAPTVLVKGLNHNTIMSNPSNELVDAVCEALEFSPEQNIQDWYYKNSDRLTPKDINPWQQFIVRAVDERDDPIPDYYIQIFTQGNEEFQGLENFGINVHTYSGDKSLRCFYVNLNGILNPQNLLLPTTLPNLVMRVIASSGSQLIDYLGIKNSGEWDAQLDISYLLRESKVKLFWPFTTTLIELKLNREPRKEVAQFLQRIKATKIY

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Crispr_ID: NZ_AP018172_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_2

1028596-1029237

Orphan

III-A:NA

Consensus_repeat	Method
GTTTCCACGAATTATTACCCCGCAAGGGG-------ATTGAAAC	PILER-CR
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATT	CRISPRCasFinder
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	CRT

8 spacers

The CRISPR arrays of NZ_AP018172_2

>merge|NZ_AP018172|2|1028596-1029237|PILER-CR,CRISPRCasFinder,CRT
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATTTAACTTTTGATATTTCAACAGCGATCGCTTTGGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATTCCTCTGGTTTTGAGTTGGGCGATCGCCTGGTGGTAGCGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATTGAACTGATTCAAGTATCATTTTATTTTGCAACTTTGGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACTTGATAATTCGTTCAGCAACACCACCAGGTTTAGTAAGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACTAATACGTCTGACGTTTAAAAGTCACTTTTATTTGGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACGTGTTGTCAACGGCGGTCTGGACGTCCGCAGGGACTGTCCCGTTAGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACGCGATCGCCTAAAAGTTACCTATTTTTTCGGTAGAAGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACCTAAACATCCCCTCGGAGACATCTTTCATTACCTGGAGGGTTTCCACGAATTATTACCCCGCAAGGGGATTGAAATACA

>NZ_AP018172|2|3|1028596-1029234|PILER-CR
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	ATTTAACTTTTGATATTTCAACAGCGATCGCTTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	ATTCCTCTGGTTTTGAGTTGGGCGATCGCCTGGTGGTAGC
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	ATTGAACTGATTCAAGTATCATTTTATTTTGCAACTTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	TTGATAATTCGTTCAGCAACACCACCAGGTTTAGTAA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	TAATACGTCTGACGTTTAAAAGTCACTTTTATTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	GTGTTGTCAACGGCGGTCTGGACGTCCGCAGGGACTGTCCCGTTA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	GCGATCGCCTAAAAGTTACCTATTTTTTCGGTAGAA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	CTAAACATCCCCTCGGAGACATCTTTCATTACCTGGAGG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAT

>NZ_AP018172|2|2|1028596-1029237|CRISPRCasFinder
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATT	TAACTTTTGATATTTCAACAGCGATCGCTTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATT	CCTCTGGTTTTGAGTTGGGCGATCGCCTGGTGGTAGC
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACATT	GAACTGATTCAAGTATCATTTTATTTTGCAACTTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACTTG	ATAATTCGTTCAGCAACACCACCAGGTTTAGTAA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACTAA	TACGTCTGACGTTTAAAAGTCACTTTTATTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACGTG	TTGTCAACGGCGGTCTGGACGTCCGCAGGGACTGTCCCGTTA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACGCG	ATCGCCTAAAAGTTACCTATTTTTTCGGTAGAA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAACCTA	AACATCCCCTCGGAGACATCTTTCATTACCTGGAGG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAATACA

>NZ_AP018172|2|2|1028596-1029234|CRT
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	ATTTAACTTTTGATATTTCAACAGCGATCGCTTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	ATTCCTCTGGTTTTGAGTTGGGCGATCGCCTGGTGGTAGC
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	ATTGAACTGATTCAAGTATCATTTTATTTTGCAACTTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	TTGATAATTCGTTCAGCAACACCACCAGGTTTAGTAA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	TAATACGTCTGACGTTTAAAAGTCACTTTTATTTG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	GTGTTGTCAACGGCGGTCTGGACGTCCGCAGGGACTGTCCCGTTA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	GCGATCGCCTAAAAGTTACCTATTTTTTCGGTAGAA
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAC	CTAAACATCCCCTCGGAGACATCTTTCATTACCTGGAGG
GTTTCCACGAATTATTACCCCGCAAGGGGATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096595128.1\|1031316_1031796_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_AP018172.1\|WP_096587188.1\|1017948_1018737_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587195.1\|1027593_1028139_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP018172.1\|WP_096587193.1\|1024888_1025407_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|178534
NZ_AP018172.1\|WP_096595129.1\|1034256_1036053_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NZ_AP018172.1\|WP_096587200.1\|1032355_1033039_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_AP018172.1\|WP_096587199.1\|1031888_1032353_-\|DUF1772-domain-containing-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587187.1\|1017693_1017933_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587190.1\|1020191_1021610_-\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_AP018172.1\|WP_096587197.1\|1030023_1030965_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|132002
NZ_AP018172.1\|WP_096587198.1\|1030961_1031252_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587192.1\|1022504_1024103_-\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_AP018172.1\|WP_096587202.1\|1033514_1034138_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153234
NZ_AP018172.1\|WP_096587203.1\|1036152_1036938_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225461
NZ_AP018172.1\|WP_096595127.1\|1025486_1026662_+\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NZ_AP018172.1\|WP_096587194.1\|1027112_1027325_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587201.1\|1033154_1033499_-\|DUF3703-domain-containing-protein	unknown	unknown	gnl\|CDD\|372144
NZ_AP018172.1\|WP_096587196.1\|1029318_1030002_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NZ_AP018172.1\|WP_096587189.1\|1018832_1019762_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_AP018172.1\|WP_096587191.1\|1022045_1022369_-\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|235016

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096587195.1\|1027593_1028139_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.00252e-09
NZ_AP018172.1\|WP_096595129.1\|1034256_1036053_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	2.04041e-59
NZ_AP018172.1\|WP_096587200.1\|1032355_1033039_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.47422e-27
NZ_AP018172.1\|WP_096587201.1\|1033154_1033499_-\|DUF3703-domain-containing-protein	gnl\|CDD\|372144	pfam12487, DUF3703, Protein of unknown function (DUF3703). This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length.	3.23536e-36
NZ_AP018172.1\|WP_096587190.1\|1020191_1021610_-\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	7.34627e-172
NZ_AP018172.1\|WP_096587197.1\|1030023_1030965_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	5.62644e-134
NZ_AP018172.1\|WP_096587192.1\|1022504_1024103_-\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	5.42348e-140
NZ_AP018172.1\|WP_096587202.1\|1033514_1034138_-\|glutamine-amidotransferase	gnl\|CDD\|153234	cd03140, GATase1_PfpI_3, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	3.14696e-65
NZ_AP018172.1\|WP_096587191.1\|1022045_1022369_-\|YnfA-family-protein	gnl\|CDD\|235016	PRK02237, PRK02237, YnfA family protein.	1.89464e-44
NZ_AP018172.1\|WP_096587203.1\|1036152_1036938_-\|hypothetical-protein	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	8.72624e-72
NZ_AP018172.1\|WP_096595127.1\|1025486_1026662_+\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	4.63365e-145
NZ_AP018172.1\|WP_096587193.1\|1024888_1025407_-\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|178534	PLN02948, PLN02948, phosphoribosylaminoimidazole carboxylase.	7.30616e-96
NZ_AP018172.1\|WP_096587196.1\|1029318_1030002_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	4.01267e-17
NZ_AP018172.1\|WP_096587189.1\|1018832_1019762_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.63484e-87
NZ_AP018172.1\|WP_096595128.1\|1031316_1031796_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.64956e-31

>NZ_AP018172.1|WP_096587195.1|1027593_1028139_+|GNAT-family-N-acetyltransferase
MLVEVKTWYLEMLDPKYLHPSDPGNYELRIEQAKIPSPEFSRFLYSSVGGNYFWSDRLSWNYERWQNYLNRKEVETWVAYISGTPAGYIELEKQPEDNVEVAYFGILPQFTGQRLGGHLLSVGVKRAWEMRAKRVWVHTCSLDSPHALANYQARGFQIYQQKVHSQELPDKPIGPWLGADS
>NZ_AP018172.1|WP_096587194.1|1027112_1027325_+|hypothetical-protein
MLISNWNVPLPLEQYLNHRVVIYYFSDGQWIPIKYCRLSKAIEIYQRTKHEVAGETLVFPVDLNPNAFKN
>NZ_AP018172.1|WP_096595127.1|1025486_1026662_+|N-acetylglucosamine-6-phosphate-deacetylase
MTKATPSATATNVDIINARIPGYKGLQMLLINQQGTIEQILPMGTVFKRVPDPDLQVLDVAGDWISLGGVDLQINGALGLAFPELQADNSHLLPKISQFLWDVGVDGFLPTLVTTSIENIQRSLAAIADFIQSQKAGAQILGVHLEGPFLNAQKRGAHPAEYLLPLTIERVKQVLGDYAQIVKVITIAPELDPTDEVIPYLRSLGITVSLGHSQATANQAQRAFELGATMVTHAFNAMPPLHHREPGLLGAAITHPRVMCGFIADGQHVAPTMLQILLRASEGLFLVSDALAPLGLPDGVYPWDSRQIEVKNGTARLLDGTLSGTTLPLLVGVQNLVKWGICDVERAIALATDAPRKAIALPGISPNQPANLLRWHWDEVTKELTWQRLFS
>NZ_AP018172.1|WP_096587193.1|1024888_1025407_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MAPLVGIIMGSDSDLPTMKDAIAVCDEFGIEHEVAIVSAHRTPERMVQYAQQAHQRGIKVIIAGAGGAAHLPGMVASLTPLPVIGVPVATRNLQGVDSLYSIVQMPGGIPVATVAIGNAKNAGLLAVQILATHQPELLEKVQQYRKSLSESVMAKQAKLEQLGYEEYLKLEL
>NZ_AP018172.1|WP_096587192.1|1022504_1024103_-|ammonium-transporter
MHKQKLRTKNRRRSVKAYSKTPQSKSKIQLLSVAIKRLSPNWQASLALATLIVFGWGYAAFAQAPAAGPTTAELKVAIDTLWVAIAAFLVFFMNAGFCMLETGFCRQKNAVNVLAKNLIVFALSTLAFWAIGFAFMFGDGNDFIGLNGFFLGGADNSPATGDAYKGIFSALNWTGVPLAAKFLFQLVFAGTAATIVSGAVAERIKFIDFLIFSLLLVGIAYPITGHWIWGAGWLADMGFWDFAGSTVVHSVGGWAALMGAAFLGPRIGKYQDKQVVALPGHNMSIATLGCLILWLGWFGFNPGSVMAADPNAIAHIALTTNMAGAVGGIAATIAAWLYLGKPDLSMIINGILAGLVGVTASCAYINIGSSVIIGLVAGILVVFSVPFFDKLGIDDPVGATSVHLVCGVWGTLAVGLFAVGPGGYPWLVDLAGKPIGPHGLFFGGGFGTLIPQIVGILSVGGITVLLSSIFWLVLKATLGIRVSSQEELEGLDIGEHGMEAYSGFITETSSDGFSQGYSSGDIPQARDLPNTL
>NZ_AP018172.1|WP_096587191.1|1022045_1022369_-|YnfA-family-protein
MMKSLFYFFWAGLFEIGGGYLIWLWLRENKSIWWGIGGGIALAIYGMIATLQPANFGRVYAAYGGVFIIMAMLWGWKIDGVAPDKYDLIGVGLSLVSVLVIMYARRM
>NZ_AP018172.1|WP_096587190.1|1020191_1021610_-|ammonium-transporter
MLKKVVMIGAMTLLLLGGPLMGNALAQAAATPPPTADTGDTAFMLISAALVLLMTPGLAFFYGGFVRSRNVLNTLMMSFVLMAIVGVTWILWGYSLSFSPGTPFIGGLQWLGLNGVGLEVTDYLKGSNPPEVVSYAGTIPHQAFMIYQAMFAIITPALISGAIVERISFRAYALFVLLWSTFIYTPLAHMVWAKGGFLGLYGGLGALDFAGGTVVHISSGVSALVAAIVLGPRKNHPDRLSPPHNVPFILLGAGLLWFGWFGFNAGSALSVSGGTSGNIVTNIATTAFVATNTAAAAAALMWLILEAVLRGKPTAVGAATGAVAGLVGITPAAGFVTPLSAILIGFITAFVCFYAVSFKHKLQVDDALDTYPVHGVGGTVGAILTAIFATTQVNSGGKDGVLRGNLGELGVELAAIVIAYIIAAVGTWIILKIIDATVGLRVKEETEYQGLDINEHGEEGYNSEFSDRINVP
>NZ_AP018172.1|WP_096587189.1|1018832_1019762_-|sugar-ABC-transporter-permease
MNQLSSKNWMLIRHQLTPYLFLLPALIILCLTVFWPALQAFYLSFTSYEDLAQPPQWIGITNFLKLWQDAVFWQTLTNTFLYLVGVVPILVIAPLALAILVNQKLGGMNWFRAAYYTPVVISMVVAGIAWKWLYAENGLLNQLFKAVGIFPEGIPWLTSPSKILGIVPISLASVMAVTVWKGLGYYMVIYLAGLQSIPADVYEAAAIDGSDGIRKHWDITIPLMRPYLALVAVISAISATKVFEEVYIMTQGGPLNSSKTIVYYLYEQAFSNVEFSYACTIGLVLFLIILGLSVVRLVIDRQGNDNITI
>NZ_AP018172.1|WP_096587188.1|1017948_1018737_+|hypothetical-protein
MNRPLLGMFWDLLSTLFLTIVSAFVISAPTIKLVSSSVESISEISASYSRRLDSLFANNSSVGVLAICVAEGNCEINGKKTQNYFQNIDPGNGLINRGWCSDQGRGGSNLANADAGCLKRTQSRIPRLIQRMKHVGLNPEHYLEAFVNATDLWNQASPRVSDAFPAAYRAALNRGLQGHEAILWARVEAFRDESGELSAGNIDMNRGVYRGLFGICANPNNTYYQSRLQTYPLMSESWRWSCIALDQRRRVKAIQSVFSVIN
>NZ_AP018172.1|WP_096587187.1|1017693_1017933_+|hypothetical-protein
MWISQVIISALATELTVEFGLFSRLRTTKIFLLNFTFFSSLPLLFQQIFLFISSVFVTLNLSSQIEVDAKKLIFYLLFR
>NZ_AP018172.1|WP_096587196.1|1029318_1030002_-|isoprenylcysteine-carboxylmethyltransferase-family-protein
MFIFKILSALMWNIIIFGGLLFLPAWTLNWWRAWVLLGVVVIGTLATMIGVFREDDELLKERLKPPIQEEQPLADKILANLLILTFLGLIAFIPLDVFRLHLFAEPSAFASVLGLLMFIIGWLIISLSFKVNTFAATAVKHQADRQQRVIDTGVYSVVRHPMYAGAVLTMVGMSLWLESYAAALLAIVPIMTLVIRIQFEEQFLKQELKGYDTYTEKVRYKLLPYIW
>NZ_AP018172.1|WP_096587197.1|1030023_1030965_-|RNA-polymerase-sigma-70-factor
MSDLETFNQHRSLLFAIAYRMLGTVTDAEDMVQETFLRWHQTAQTTVKSAKTYLATITTRLCIDRLRSAHVQREKYVGTWLPEPIVTQQTADPVDQLELADSLSMAFLVVLERLSPIERAVFLLREVFDYDYDEIAQIVGKSQANCRQIFKRSRQHISDRRPRFPVSDRQQEEITAQFVKASTQGNLQGLLALLAKDVTYWSDGGGKVVAALKPLQGAMKVGKFLLALRSKWLSTSISQIAGINGQPGIILFVNDRIHSVTTFEIFDGYIQSVYTIRNPDKLKRIAEKLNCQSEMNPKPMSSNAQNNFTDLAT
>NZ_AP018172.1|WP_096587198.1|1030961_1031252_-|hypothetical-protein
MRGNYAIAPIAALILFWTQFQQAGSWLLLISMASAMLFGLYHHFIAIGSDRIFEIPFAAWGVLFHITAIFLLLTEGIGCAIGAWALSTLRRREQFL
>NZ_AP018172.1|WP_096595128.1|1031316_1031796_-|carboxymuconolactone-decarboxylase-family-protein
MELKVESAAYRAMVQLERYVRSSGINPTLLELIKIRASQINGCAYCIDMHTKDARLNGETEQRIYALNAWRETPFFTDEERAVLAFTEAVTSIATHQVTDEIYNEVSRYFTPDEVANLLMAIVTINSWNRIAITTRMLPGSYEPGALQHKKGVAEKLSV
>NZ_AP018172.1|WP_096587199.1|1031888_1032353_-|DUF1772-domain-containing-protein
MFLKIWRLLTLILVALFMGLEFAHTLELPAKMQYDGALYVTIQNSLYRYFGAPGPGAFITVGAVLWAIALTVLVRKHKSAFWWTLAGTLCLAIAFPLIYFLRIEPVNVAIEQANAGSLPTDWQQLRNQWEYAHATNFGLSLAGFSAIAMSILDG
>NZ_AP018172.1|WP_096587200.1|1032355_1033039_-|methyltransferase-domain-containing-protein
MEWTIGWWQISVQRIYPTNAQLSQTYNQAASWWHQHLQFLGYSHAYRELWRSLKNSNILPLGQDKLTICDCGIGTAAFSLAFAQIINPKTQITGVDISSQMLQKADQKLSVANVPHRICQSDVNTLPFADRSFDGVICAHTLEHLPDPIQGLQEMVRVLRPGAPLILVVTQSGLLGWLIQWYWGNRCFNREELSKLIHEVGLTQLQFVPFPVGLARFTSIACIGFKR
>NZ_AP018172.1|WP_096587201.1|1033154_1033499_-|DUF3703-domain-containing-protein
MKAILYEHFHAELDKAKKFIAEQDFESAWIALQRAHILGQTDAIAHVIAHWNMLKLAWKQRDFKEIAGQLLPTFLAIPLTLLYGKKRYLRGGKANVNNSEKMTIPEDIQQILSQ
>NZ_AP018172.1|WP_096587202.1|1033514_1034138_-|glutamine-amidotransferase
MEKQIVHLFIFNTLADWEIGFAVAGINNPAFQKHPGRYRIQTVGLDAEPVTTIGGVTILPDITLDELNSSAMLILPGGEVWNAGKNAEILETVKALLVSGIPIAAICGATAGLARAGILDDKPHTSNASEYLQATNYRGAAFYQNQPAVTAGDVITANSTAPLEFAYHIFKKLDIYDTPILEAWYALFKTGDASYYFTLQKLRSPST
>NZ_AP018172.1|WP_096595129.1|1034256_1036053_-|helix-turn-helix-transcriptional-regulator
MNGAEILEQLERQNLFVITLDANHTWYRYHHLFAESLRHILHRIEPDGGGKYHYRAAQWYEQQGYITEAIQHAISAKAFEYAASLIEQEVQTKENPRIDALFLRNVLNELPAQLTDSRPWLLVAKAWAAFTSSQFPDAIAIVQTLERLLNQGIDPTENSDRLWGLVVALKGMQARQQGNTAESVAFMEKALHLLPSDNSWLRSLILLNLGVTYFVGDNYQGAKQLLKEVSYIGKVRGTADPAIAGLYLQAQFLALRGKLDDATSLCQQGLELATERRWLATYAGVLVQVALADLLREQNQLADAAQHLTQSIERAIQNQQPGLMMGYITLARVRQAQGDFPAAWAAIHGAEHCQLWVWPTILAVEACKVRLYLAAGNLDAAIAWVEKSNLSVEGKLRYSITEQYPTVSELNYLTYARLLLAYGQLQDALGLLKRLYKFAQAGGRTIRMMETLLLQALVLQAQGDREESVNYLNQALNIPHQGNYIRLFLDEGKPMAELLQQAVSKNIHSSEVNRLLAAFGSLAPKKSTLIPALIEQLTDRELEVLNYLATGMSNQAIADQLFVSLAAVKWHARNIYGKLEVKNRTQAVTKARELRLLS
>NZ_AP018172.1|WP_096587203.1|1036152_1036938_-|hypothetical-protein
MVSPLLVTKLHLPSSRSPLVQRKRLWEKLDWGLTSRLILISAAAGFGKTTVLSEWAHQTQAFVSWLSLDEQDNDPTRFWTYIIAALQQNIQDIGEATLAMLRSSEPFPFEVFLTPLINELAQLETALILVLDDYHLITTPEIHDSLTFFLEHLPTQIHLAIATRVDPPLPLARLRVRSQLTELRAEDLRFTDEEAVTFWHQSVSQPLTDAQIATLQTQTEGWVAGLQLAMLSLRDSISHDVFINSFGGNKRYILDYLVEEV

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Crispr_ID: NZ_AP018172_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_3

1362234-1362623

Orphan

Consensus_repeat	Method
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	PILER-CR
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	CRISPRCasFinder
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	CRT

5 spacers

The CRISPR arrays of NZ_AP018172_3

>merge|NZ_AP018172|3|1362234-1362623|PILER-CR,CRISPRCasFinder,CRT
GTTTTCAATTAATTACCCCTCACGGGGATGGAAACAATCAGTGTAAGACAAAGCTTGAAGCACTATTAAAACGTTTTCAATTAATTACCCCTCACGGGGATGGAAACGCGATTGCAAAGAGGTTGCTGGTGTACGCAATGTAGTTTTCAATTAATTACCCCTCACGGGGATGGAAACTTGAATGTTAAAATGAAAGCGAAAACTATCAAAATCAGTTTTCAATTAATTACCCCTCACGGGGATGGAAACTTTAGTAAAAATGAAAACCCCACGATTTTCATCTAGTTTTCAATTAATTACCCCTCACAGGAATGGAAACTGTGCAGGCCATGAGACGATATGCACCCAACCCATAGTTTTCAATTAATTACCCCTCACGGGGATGACAAC

>NZ_AP018172|3|4|1362234-1362552|PILER-CR
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	AATCAGTGTAAGACAAAGCTTGAAGCACTATTAAAAC
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	GCGATTGCAAAGAGGTTGCTGGTGTACGCAATGTA
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	TTGAATGTTAAAATGAAAGCGAAAACTATCAAAATCA
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	TTTAGTAAAAATGAAAACCCCACGATTTTCATCTA
GTTTTCAATTAATTACCCCTCACAGGAATGGAAAC

>NZ_AP018172|3|3|1362234-1362623|CRISPRCasFinder
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	AATCAGTGTAAGACAAAGCTTGAAGCACTATTAAAAC
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	GCGATTGCAAAGAGGTTGCTGGTGTACGCAATGTA
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	TTGAATGTTAAAATGAAAGCGAAAACTATCAAAATCA
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	TTTAGTAAAAATGAAAACCCCACGATTTTCATCTA
GTTTTCAATTAATTACCCCTCACAGGAATGGAAAC	TGTGCAGGCCATGAGACGATATGCACCCAACCCATA
GTTTTCAATTAATTACCCCTCACGGGGATGACAAC

>NZ_AP018172|3|3|1362234-1362623|CRT
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	AATCAGTGTAAGACAAAGCTTGAAGCACTATTAAAAC
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	GCGATTGCAAAGAGGTTGCTGGTGTACGCAATGTA
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	TTGAATGTTAAAATGAAAGCGAAAACTATCAAAATCA
GTTTTCAATTAATTACCCCTCACGGGGATGGAAAC	TTTAGTAAAAATGAAAACCCCACGATTTTCATCTA
GTTTTCAATTAATTACCCCTCACAGGAATGGAAAC	TGTGCAGGCCATGAGACGATATGCACCCAACCCATA
GTTTTCAATTAATTACCCCTCACGGGGATGACAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096587436.1\|1357756_1358836_-\|ATP-binding-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587443.1\|1369971_1370847_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_AP018172.1\|WP_096587433.1\|1351192_1353211_+\|transglutaminase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376628
NZ_AP018172.1\|WP_096587442.1\|1368385_1369882_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|130902
NZ_AP018172.1\|WP_096587440.1\|1364276_1366370_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274311
NZ_AP018172.1\|WP_096587439.1\|1363178_1363574_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587430.1\|1348077_1348773_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP018172.1\|WP_096587435.1\|1354284_1357002_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_AP018172.1\|WP_096587437.1\|1359115_1360645_-\|GMC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|225186
NZ_AP018172.1\|WP_096587447.1\|1377227_1377413_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587446.1\|1376103_1377171_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340832
NZ_AP018172.1\|WP_096587438.1\|1360673_1361495_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|212493
NZ_AP018172.1\|WP_096587445.1\|1374869_1375652_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NZ_AP018172.1\|WP_096587429.1\|1347371_1347764_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587448.1\|1377552_1378581_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176197
NZ_AP018172.1\|WP_096587432.1\|1349846_1351196_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|376643
NZ_AP018172.1\|WP_096587441.1\|1366676_1368140_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NZ_AP018172.1\|WP_096587434.1\|1353243_1354185_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_AP018172.1\|WP_096587431.1\|1348868_1349831_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_AP018172.1\|WP_096587444.1\|1371016_1374844_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226434

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096587443.1\|1369971_1370847_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.26286e-63
NZ_AP018172.1\|WP_096587433.1\|1351192_1353211_+\|transglutaminase-domain-containing-protein	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	1.13886e-19
NZ_AP018172.1\|WP_096587442.1\|1368385_1369882_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	1.58047e-66
NZ_AP018172.1\|WP_096587440.1\|1364276_1366370_-\|hypothetical-protein	gnl\|CDD\|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	4.686e-08
NZ_AP018172.1\|WP_096587434.1\|1353243_1354185_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.74551e-09
NZ_AP018172.1\|WP_096587430.1\|1348077_1348773_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	7.38025e-20
NZ_AP018172.1\|WP_096587435.1\|1354284_1357002_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	2.32678e-60
NZ_AP018172.1\|WP_096587446.1\|1376103_1377171_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340832	cd03802, GT4_AviGT4-like, UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.	2.31354e-158
NZ_AP018172.1\|WP_096587438.1\|1360673_1361495_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|212493	cd08932, HetN_like_SDR_c, HetN oxidoreductase-like, classical (c) SDR. This subgroup includes Anabaena sp. strain PCC 7120 HetN, a putative oxidoreductase involved in heterocyst differentiation, and related proteins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.57022e-63
NZ_AP018172.1\|WP_096587445.1\|1374869_1375652_-\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	2.53298e-136
NZ_AP018172.1\|WP_096587448.1\|1377552_1378581_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176197	cd08235, iditol_2_DH_like, L-iditol 2-dehydrogenase. Putative L-iditol 2-dehydrogenase based on annotation of some members in this subgroup. L-iditol 2-dehydrogenase catalyzes the NAD+-dependent conversion of L-iditol to L-sorbose in fructose and mannose metabolism. This enzyme is related to sorbitol dehydrogenase, alcohol dehydrogenase, and other medium chain dehydrogenase/reductases. The zinc-dependent alcohol dehydrogenase (ADH-Zn)-like family of proteins is a diverse group of proteins related to the first identified member, class I mammalian ADH. This group is also called the medium chain dehydrogenases/reductase family (MDR) to highlight its broad range of activities and to distinguish from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal GroES-like catalytic domain. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	2.70854e-113
NZ_AP018172.1\|WP_096587432.1\|1349846_1351196_+\|DUF58-domain-containing-protein	gnl\|CDD\|376643	pfam01882, DUF58, Protein of unknown function DUF58. This family of prokaryotic proteins have no known function. Caldicellulosiruptor saccharolyticus PepX, a protein of unknown function in the family, has been misannotated as alpha-dextrin 6-glucanohydrolase.	4.70831e-19
NZ_AP018172.1\|WP_096587441.1\|1366676_1368140_+\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	6.69346e-102
NZ_AP018172.1\|WP_096587437.1\|1359115_1360645_-\|GMC-family-oxidoreductase	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	4.57568e-86
NZ_AP018172.1\|WP_096587431.1\|1348868_1349831_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.12303e-98
NZ_AP018172.1\|WP_096587444.1\|1371016_1374844_+\|PAS-domain-containing-protein	gnl\|CDD\|226434	COG3920, COG3920, Signal transduction histidine kinase [Signal transduction mechanisms].	7.4438e-67

>NZ_AP018172.1|WP_096587438.1|1360673_1361495_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTSIAGKTVLLTGASGGIGAFIARALAKEQATVVSVSRSPEKLEAISNEVQALGGRGISIPFDISKVEELPVLVQQINQIAGQIDIVINNAAIEKYRAFQNYALADIQSMLTTNLIAGMELTRLILPTMIARDSGHVVNIASGSGKKGAPYNSIYSATKAGMIMWTDALRQELADTNVGVTVICPGYTKAGMFLAFGLPSPKLAQVSHPSEVAIAVLQAIKQNQPEVVIDGFLTKLLFSNIQLFPKFGDVIYRWIGLTQLNKTCAENQMRRDS
>NZ_AP018172.1|WP_096587437.1|1359115_1360645_-|GMC-family-oxidoreductase
MADAHYDAIVIGTGAGGGTLAYKLASNGKKVLVLERGNFLPRKKTNWDSQQVLRKDFYRTTEQWYDKDNKVINPLTHYYVGGNTKFYGGALFRLREQDFEKVIHQGGISPEWPLKYRDFAPYYDEAEKLYEVHGQRGLDPTEPPIDRDYPFPAISHEPYIQQIHDALKGQGLHPFYLPLAIKLNEINRHLSTCIRCDTCDGFPCLINAKADADVNCIRPAMADANLTLITEAKVVRLQASASGREVTGVEAEIAGKSHIFTGDIVVVACGAINSAALLLKSANDQHPNGLANSSNLVGRNYMAHNFGVVMTLSTKLNPTVFQKTLAVNDFYWGDKDFTYPMGNVQMLGNVNKDRIAAHGPPLMPGFIAEAIANHSIAWLAMNEDLPDINNCVRVQGDRIIIDYTPNNQQAFNRLIQCWIEVLKSIEPFACHIPQKMTVKEVGHQCGTCRFGEDPKTSVLDINCRTHDIDNLYVVDGSFFPSSTAVNPSLTIIANALRVGEHLLERMIKY
>NZ_AP018172.1|WP_096587436.1|1357756_1358836_-|ATP-binding-protein
MLDLSTPLQLIGRSAEFQHIVEVLARDGDLLITGVPGSGRRTLVRGAAQEVGAIVLEIDCIRAIDGQRFVQLLAETISQNWQPAKIQDWVAQNASEFFVLNLEGKLKLLHSLNQKQLWQAFEILLQLPQIIAVDLHQRVVLILQSFPHIRSWDRNGLWETTLRREIKVQTDVSYVLIATIAESSQQTDETNYPLETVQLPPLAKDVLAVWAREILHTQGLKFDSRSQALQLFLDAVQGHIGDAMTLIRRLQTLCRPEALITEKEVQQAIAELLKDLSITFESLLMLLPANQVHLLECLALDSTDKPQSKEYIQKHGLSRGGSLQGALTGLQHKGLIYNAEQGYRLALPLLALWLQQRLS
>NZ_AP018172.1|WP_096587435.1|1354284_1357002_-|response-regulator
MTDSHPIAPMRRRLVITLLGLLALILAHKMALIYRIQPGVSLWFPPSGVAIALTFWLGPYGIVLTAIASFLMAPFWGLNGWEQLVGLLDGIEPLIAWLLYRRFSQGSLRLNSLRDAAIFTLSVPLAASATLAVVGSLAWVALGKMPADTLAQSIPHWWLGNAMGVMAITPTALLVLTPYLQSWGWFPKSETADPTLNALIFQKPRRFAGEISIIILLCVAIAALTVAETNNKTFRFQQLSFLSFVPVLWAASRFGVTSGMLISSLCVFVTLFFYLVAYPNAILLPEIPVPPEVLHVHKLSLLVQCAVALLVGTAITQRAKIQVALAVERVRLGEYQARAELSEQLIQLNNSLVETNARLEESNRDKDEWLYREQALRQRLVNILEGMSDAFIAVNRDWQITYVNRQAAKITDLEPQKLIGKNFWQQWPNSKGTQFEREYLRAFTEAIPVHFEAFCESGNQWFEVHAYPAEDGLGIFFRNITERKQAEVEREQILEREQAARTEAETANRIKDEFLAVLSHELRTPLNPILGWATLLKTEKFQRGEKLLRAVETIERNAKLQIQLIEDLLDISRIQQGKMVLNIQPLNIVHIIEAALETMHLALEAKNIQIKTSFNRPICLVCGDAARLQQIVWNLLSNAVKFTPSGGQVEVRLEQVDTYAVIQVQDNGKGISSEFLPHVFEYFRQADGKSNRQFGGLGLGLAIVRHLAELHGGCVQAQSQGEGEGATFTVKLPLMVEPPQINQDNRDCNNSLNLAGLRLLVVDDDIDTDELLTVMLEDLGASVTAVTSAGEALEIIAKSPPDLLLSDIGMPGIDGYMFIRLIRAMPPEKGGDIPAIALTAYAGEINQKKALAAGFQMHLAKPVALEELLKVTAQILASRNREQKIKEVEMYLAAQKSNRSSSVKI
>NZ_AP018172.1|WP_096587434.1|1353243_1354185_-|GNAT-family-N-acetyltransferase
MSISIRLLQANELATADRIFRLAFGTFVGLPEPSQFAGDAAYIQHRWQTDPNAAFVAEVDGKIIGSNLVVNWGSFGYFGPLSVHPDFWQQKVGQKLVEPAIACFTEWQTQLAGLFTFATSPKHHALYQKFGFNLRFLTPILGKSVQPSQVIPPGMRYSQLTEDKRAEFLKASYQLTDAIYEGLDLTREIQTVNQQALGDTVLFWDDIGLAGFAVCHYGAGTEAGSDTCFVKFGAVQSGTGAGERFEQLLDLCEHLAVTQGMSKLLAGINTSRDEAYRRAIARGYRSEVIGVAMHRPNEPGYNRPDVFAIDDWR
>NZ_AP018172.1|WP_096587433.1|1351192_1353211_+|transglutaminase-domain-containing-protein
MKPPVLLLSAALIFWGWQTGMWIFAIPMALILAGYRLINSRWDFSYEDFRRIANLCLIILIIVFVSLITTNRSIYLIYNLLQWFPLVFFPLLAAQTYSVNENIDIRTLFISQKNVIKSESRRYIINLSYPYFALCMLSAGAANTRDISFYIGMFLLTSIALWFIRSPRFSPIIWLSLILLAGSMGFVGQIGVYQLQQKLEDTVVSWLSKSNNIGQLTDSTIKQTSIGEIGTLKQSNEIIFRVASDNQNVAPGLLREATYDKYKSTFWVASNSNFTTVQPEMNGKTWRLGNAPADSSKLTISATLNQGKGLLRLADGTFEIDELPVSQMEKNKYGTVKVEGKDNAIAYRILFNKSLSLDSPPTEEDLQIAQPETEAINQIISQLDITGKSPRAILERVDSFFIKNFRYSLKFIENNHRATPLSTFLLKTRAGHCEYFATATTLLLRAAGIPARYAVGYSVREFSQLENQYIVRSRHAHAWTLAYINGKWQAFDTTPADWASIENANASKLAFISDLWSFFSFKLSSWLRSGLMSNLFKYGWWLILPLILLRLWKFNSHNKVRRLSTKQISAKQVAKVDINRKEYEFYLIEKTLNELGFSRQPSESLKNWIERLEKELPNSDLINDLTSLVELHYRDRFDPQGIKETERARLKSAVQAWLVMLQTQFPKNSARN
>NZ_AP018172.1|WP_096587432.1|1349846_1351196_+|DUF58-domain-containing-protein
MKLFIYRLFYFSYGIQRKLTRRVTVSGMVVSVLAIAAALTGSSNASMNYQIVTFLVSILIISVVSSLLFRYRFGANRHLPRFATVGVNLKYKIVIHNKSNKIQKGLKLFENFADPRPNFKDFLETSETRKVKKHSLVQAFGYDRWLWLISRKQCAKALPIDLPTLAPNSKTEVVGEIIPTQRGVIRLTGMTVARPDPFGLFKACKSISLAQSLLILPKLYQLPPVQLPGVKKHQSGGVALASSVGDSEEFRSLRDYRPGDSLRKIHWKSWAKVGKPIVKEEQDEFFVRHALILDTFQSVNYSEILEEAISIAASLACEVQTQESLLDLMFVGNEAYCFTFGRGLSHTDKMLEILASVVACRDKSFDSLIPVVLEKLSLLSGCICIFLCWDEDRKILVNYLRSVGIHTLVLIVTDKEGKLDNFDLDSLNDRLTRSHILKLGKIQEELMHI
>NZ_AP018172.1|WP_096587431.1|1348868_1349831_+|MoxR-family-ATPase
MENSYPKAHDLPSKEIYQRIFNNIQKVIKGQSAAIRKLLSAFASGGHVLLEDYPGTGKTTLAKALAYSVDVSFKRIQFTPDLLPSDILGISMLDPNERTFHFHEGPIFAHIVLADEINRASPRTQSALLEAMAEFQVSIDGNLRKLRDPFFVIATQNPVESRGTYPLPEAQMDRFALQFSLGYISPEDEVNLLSDQIQQHPIDSIQPCIDLQDIIILKQQVKQVRISQELKTYLVDIVNATRSAQGVQLGASPRASIALMKIAQALALFDGYEFVTPEHIQELAVSVIAHRLVMEPQARFSGKTATSVVEDILKSVPVPV
>NZ_AP018172.1|WP_096587430.1|1348077_1348773_+|pentapeptide-repeat-containing-protein
MKNNILISLISSLNQKKQSVLLFDSIAAANEIALMLNGQWDGCNGVILDQCDEVAVNTATKLTEATWCYQGAARTVLARLTTDELLRRYAIGERNFINANLRCAVLTSMKLNQINFSHAKLSWAVLNQVDLSQANLTAADLSEAHLIGADLTRAEIVRANLTQTNLQQANLRGANLTRANLSEVNLTDADLTGANLALADLRGAKFHSCNLSRANLTGAKFIESDLAFANR
>NZ_AP018172.1|WP_096587429.1|1347371_1347764_+|hypothetical-protein
MKLLGLILPTFLLLSTPAIAVEFNGKNIDGQKLPAKAYYYGTGGIYNVQVSFHKRRATIYFTDGNQSTIQLNQQVITDSKNIVGFGKLGQFPINRNFSVGLVYDNDGVGSSSSQLQQSNPLEGFWRISLD
>NZ_AP018172.1|WP_096587439.1|1363178_1363574_-|hypothetical-protein
MTRQKRISRVLDTAKFRVANFQAIDPNMTFDDDCNLQNLTQTIDEFRNVLDTYNAALALVDSSKTKVDAMERTLRSLSDKMLRGVGFRYGRDSDEYELAGGVRDSERTRKSRLTRLKNLAEEAAKANSETA
>NZ_AP018172.1|WP_096587440.1|1364276_1366370_-|hypothetical-protein
MSAKHIPLPAHVALLEKYRQKTQNNLWHTLPHDGYIHQHLVWHLEKAGRFEEIHSLLREESPTGNNGWFEVREKLAQTGGYIADISRAWELAEANWQESTPQVVGLQCRYALMMASINSLATNIPAQLLVALVKNHVWTAEQGLAYAQQHLKPEEKAKALAELVNYLPPNLTQLAVSQGVSVTSDSLSRLEQTPPEVLSAALAAVRAIASEFDCTEELRDLVPQLPAELLPEALAIARMIGDEYYLTPVLSALTEKLPTELLSAALATASTIQKEYYRAKALMVLAQKLPEVLPAALTAARVIEDGMTRAEVLIALVEKLPPELLPEALAAARETQDDYYRAEVLIALAQRLPELLPEAIAAAREIQDESCRSHRLSELAEKLPPELLPEVLAIARKIQDRYERAHPLIALVEKLPEVLPEALAAAEAIHDEYYRAEVLIDLAQRLPEVVPEAIAATEAIQKESSRDYQLRELAEKLSPELSPEVLTVARKIQNDCYRADALIVLAQKLPHILPEALATARTIEDEYYRADALIALVEKLPEILPEALATAKAIEDEYHRADSLSTLVPKLPPELLPEALAAIRAIQDESLRVNALSALVDKVPQVLPEALACAARVVPPTYLDPKALTALACGLSQLPAAEIFPLWQDTLHKLSLGDRPRLLRYIAVFSPVIWALGGQAATVEVIRAIYDVTRWWK
>NZ_AP018172.1|WP_096587441.1|1366676_1368140_+|S8-family-serine-peptidase
MPLDYTNNKSSADNGLNVTPVSSVDAFHAKDDYTLNPSGRSSFDSAIANDNQDTVSAQSYDSTTGYGKVNAAAAVAKAIGQNTFADVPDIGGNSWGADAVKAPEVWARGYTGQDVVVAVIDTGVDYNHADLRNNIWTNTREIAGNGVDDDGNGYIDDARGWNFVDNNSDPLDGNGHGTHVSGTIAGENNGFGVTGIAYNSKIMPVKVLNDSGSGSISSITKGIYYAVNNGANVINLSLGSDFPNSSLASAIEYASKKGVVVVMAAGNNGLPILSYPASYANQWGLAVGAVDRDNNIADFSNRPGITQLSYVTAPGVGIYSSVPGDQYANYSGTSMAAPHVAGVVALMLSANHSLTDAQVRQIITQTASNGAPDPDTGFSAGSAVSQLIADIAGNTSRYSWASFESSAIASDYTVDFTSKNSSQPEINDSFANANISSQFRYYEDNLNDNIYNSLAKEQPNEQPSDLEKMLQQFQKQMDELRKWFANM
>NZ_AP018172.1|WP_096587442.1|1368385_1369882_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MKYSLVANATQARQTKQRFAKPDEQLSYELGKAVQELPPLYTRLLAGTIGVIVFGAIAWAHFSEIDEVAIASGELIASTQVRPVTSLGGGTIINIKVKEGDRVSKNQVLIQRDPDLKQSDVNRLAQASKLIQQDLQRLDAERVGVKTTGTKLQDELLNSRLADYQARQTAAEAEANRQQAIRDQAKVRLTRLKENLTSAKSTLGNAKINLVNAETISVKIETNLAIAQKREQSLRTLIKPGAVPRVDYLEAQERLNRATTEITRARDEVINAHNRIIEAQDRVTSLERDIAAQAQEIRQAEQAYQAARSQAQRLASERQSEILTQINKRQEELTNVNGQLEQAQKQEDEETIKAPFSGTIYKIKATKGPVQTGEELLSILPEGEEMLLEVKVLNRDIGFIRQGMKAKVKMATFPFQEFGVIEGDVVQVSPNAITDKDLGLVFPTRIKLNKHSINVRGQEVALTPGMAANGEIVTRKKSILTFIMEPVTRRFSEAFSVR
>NZ_AP018172.1|WP_096587443.1|1369971_1370847_-|SDR-family-oxidoreductase
MILVTGATGGIGRRVVRLLRQQEKPVRAFVRLTSHYGELEHRGAEIFIGDLRREKDIQQACRGVEYIISTHGSDSDALSLDYRANIELIDQAKANGVKHFVFISVLGADRGYEDAPVFKAKRAVEKYLQASGVNYTILRPAGLASNLLILAERFRETGLYLLIGDPKNRTSIVSTDDLAKMVVDSLTVEGARNQTLAVGGPEILLRGDIPQIFGRIFNKEPTVINPPLFAIDGLRSALGLFIPQKSQALGTYRTLLANEFFCTKEEISNLENIYNFKLETLENFVRRYLAV
>NZ_AP018172.1|WP_096587444.1|1371016_1374844_+|PAS-domain-containing-protein
MTVEKESAFMDWLIGGGEMGKLIRSKDWSNTPLGAIASWPQSLRTTVSLCLASNFPISITWGSQHIQIYNDGYWPICGAKHPHAMGQDFRECWASAWPAIEEAFNRACAGETSYLENQRMFLDRHGYLEETFFTFSFSPIRDETGGVGGLFHPVTELTQQTLAERRLKVLRNLSHNTTDAKTVAEAIALVAQTLTQQALDLPFVLIYVVDADCKQAQLIESVGLAKGTVASPILIDLESSSTWPLTEVLQSQQSLLVDDLAGRFGSFSCGPYSEPPQTAIILPINLPGMEHLFGLLVAGISARRALDRPYQLFYDMLGDAVTNALAKAHAYEVERKRAEALAEIDRAKTVFFSNVSHEFRTPLTLMLAPLEDALADIEAALPPTQRDRLELVRRNGLRLLKLVNTLLDFSRIEAGRIQAVYEPTDLATFTADLASTFRSLIERAGMCLVVDCPPLPVEIYIDREMWEKIVLNLLSNAFKFTFTGTISVRLQNLSDRVELAIADTGTGIPPEEIPHLFERFHRVKGVDGRSFEGSGIGLSLVQELVKLHGGTVKVTSKLSEGSCFIVSIPTGFTHLPPDKIGGSRTLASTAIGTSPYVEEALRWLPEAETENSSLSAHTLPHFPHSLPSPAYILIVDDNADMRNYIQRLLGQRYEVEAVEDGIAALNAIYKRLPDLVLTDVMMPRLDGFELLRQLRANPRTQELAIILLSARAGEESRIEGLETGADDYLVKPFSTRELLARVEANLKMAQMRKDTAVREYALRLSAEKAQREAEATFEQLTHVLDSMSDAFVRLDKDWRIVDLNAAAEKINKKPRTAVIGKTQWEEWPASVGTNIEFQYRRAITKHIPVHFEHHYYVPPNYDVWVEIHAYPLTEGLGVFFRDITERKQAEAKLKQSHEELEIRVAERTAELSQINADLQQSESILRSFFNSGAMLMGIVELHGDDILHISDNQATAQFFGTTPEAMQNRFATELGIPQPTIQKWLSYYRQAQQIQAPVQFEYPHDTPTEQRWLSATVCPIAFSHKGYPRFSYIVEDITARKQSEARIEASLREKEVLLKEIHHRVKNNLGIVSSLLQMQSRRTQDIQANAILRDSQNRIASIALVHEKLYGSQDLSNIDFAQYLRDLTAHLFASTNINSRQIKLNVQVENVALDIETAVPCGLIVNELISNALKYAFPDDSPAQTLREGEIHIGLSQASLVIEGQPQNILTLIVRDNGIGLPENFDIKKAKTLGITLVQGLVRQIQGKLEINCQQGTEFKITFLANQPVPKIELW
>NZ_AP018172.1|WP_096587445.1|1374869_1375652_-|exodeoxyribonuclease-III
MKIATWNVNSIRTRLEQAIDWLNQNPVDVLCLQETKVVDADFPRSPFEKLGYQVYISGQKAYNGVALISRQPLLDVSTGFTSIVPNLQPEWDEQKRVITGMIDDVRIVNLYVPNGSSVGSEKYEYKLRWLTVLREYLQILLKSQSAICVCGDFNIALEAKDIHEQVKADNHIMASEPERQALRDILTLGFADAFRKFTSEGGHYSWWDYRTAAFRRNLGWRIDHHYLTPVLYESAKSCIIDVAPRKLPQPSDHTPVIVEF
>NZ_AP018172.1|WP_096587446.1|1376103_1377171_+|glycosyltransferase-family-4-protein
MKIAQVAPLWERVPPPTYGGIELVVSHLTDELVRRGHEVTLFASGDSQTLANLEAVYPRALRLDPNVKEYAVYEMLELSQVYQRSQEFDIIHSHVGISALSLASLVSTPTVHTLHGSFTKDNRKAFSHHQKQPYISISNAQRQIDLNYFGTVYNGIKPEDYPFKEKPQEPGYLAFLGRFSPEKGPHHAIAIAKQSGWRLKMAGKIDVVDSKFFEQEIAPHIDGQQIEYLGEVNHTQKAELLGNAAITLFPITWQEPFGLVMIESMATGTPVIAMNLGSVPEVIAHGETGFICQSYDQMAEMIPQALKLNRLNCRKHVESKFSVAQMVNGYEAVYQQIIKDRIDLNGHIHAAKIHF
>NZ_AP018172.1|WP_096587447.1|1377227_1377413_+|hypothetical-protein
MSMRTNTCPCCGGSLLRHIRHSEVYWFCLSCRQEVPLLTLSRLSNGETRNTGVLPQPTVNT
>NZ_AP018172.1|WP_096587448.1|1377552_1378581_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MLAALLYGQEDLRLKDVADPTPAAGEVVIQVGAATTCGTDLKVWRRGGHARMLTPPTLFGHEAAGQIVALGEGVTGWQIGDRVVANNSAPCMNCFFCQRREYSLCPNLTWNNGTFAQYLKIPAPIVQHNLWRIPDELPYELAAMTEPLACVLHGVGRTQIKAEDRVVVLGDGAIGLMFVAALADRAAEVWLWGGNDQRLEIGQKLGAAKTFNYHQTPDIPGVVKELTQGWGADVVIEATGVPSVWETAIACARPGATVNLFGGCPRDTSITVNTEQLHYSELTLKGVFHNTPEYVQAALAAIASRKHPLELLISEHRPLKDLAQVFNDMKARKVIKVALTPE

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Crispr_ID: NZ_AP018172_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_4

2019125-2019202

Orphan

Consensus_repeat	Method
TTTGATTGACTGGTACTCAACCAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018172_4

>merge|NZ_AP018172|4|2019125-2019202|CRISPRCasFinder
TTTGATTGACTGGTACTCAACCAAAGGCTATCAACAAAGTCGATTGATCAATTTTGGTTGACTGGTACTCAACCAAAG

>NZ_AP018172|4|4|2019125-2019202|CRISPRCasFinder
TTTGATTGACTGGTACTCAACCAAAG	GCTATCAACAAAGTCGATTGATCAAT
TTTGGTTGACTGGTACTCAACCAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096588078.1\|2017166_2017907_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227364
NZ_AP018172.1\|WP_096588087.1\|2023324_2028022_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|274362
NZ_AP018172.1\|WP_096588089.1\|2028709_2028946_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588082.1\|2019600_2019993_-\|response-regulator	unknown	unknown	gnl\|CDD\|381104
NZ_AP018172.1\|WP_096588072.1\|2011323_2011827_-\|lipocalin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|372819
NZ_AP018172.1\|WP_096588076.1\|2014408_2015377_-\|acyl-CoA-desaturase	unknown	unknown	gnl\|CDD\|224316
NZ_AP018172.1\|WP_096588081.1\|2019237_2019426_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588086.1\|2023065_2023284_-\|DUF4351-domain-containing-protein	unknown	unknown	gnl\|CDD\|316753
NZ_AP018172.1\|WP_096588071.1\|2010353_2011229_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP018172.1\|WP_096588073.1\|2011870_2012755_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225139
NZ_AP018172.1\|WP_096588088.1\|2028221_2028479_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588084.1\|2021820_2022363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588075.1\|2013334_2014168_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239583
NZ_AP018172.1\|WP_096588083.1\|2020098_2021628_-\|response-regulator	unknown	unknown	gnl\|CDD\|380161
NZ_AP018172.1\|WP_096588085.1\|2022443_2022926_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588077.1\|2015403_2017170_-\|fatty-acyl-AMP-ligase	unknown	unknown	gnl\|CDD\|341254
NZ_AP018172.1\|WP_096588079.1\|2018158_2018512_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NZ_AP018172.1\|WP_096588090.1\|2029250_2029715_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588074.1\|2012794_2013106_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|214834
NZ_AP018172.1\|WP_096588080.1\|2018516_2019110_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369506

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096588078.1\|2017166_2017907_-\|hypothetical-protein	gnl\|CDD\|227364	COG5031, COQ4, Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism].	1.37932e-67
NZ_AP018172.1\|WP_096588087.1\|2023324_2028022_-\|PAS-domain-S-box-protein	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.00411e-86
NZ_AP018172.1\|WP_096588082.1\|2019600_2019993_-\|response-regulator	gnl\|CDD\|381104	cd17552, REC_RR468-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains. Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.10586e-61
NZ_AP018172.1\|WP_096588072.1\|2011323_2011827_-\|lipocalin-like-domain-containing-protein	gnl\|CDD\|372819	pfam13924, Lipocalin_5, Lipocalin-like domain. This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5, which is involved in biosynthesis of alnumycin. The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein. The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyze a final cyclisation reaction.	2.19639e-48
NZ_AP018172.1\|WP_096588076.1\|2014408_2015377_-\|acyl-CoA-desaturase	gnl\|CDD\|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	1.00852e-64
NZ_AP018172.1\|WP_096588086.1\|2023065_2023284_-\|DUF4351-domain-containing-protein	gnl\|CDD\|316753	pfam14261, DUF4351, Domain of unknown function (DUF4351). This domain is found in bacteria, and is approximately 60 amino acids in length.	6.8678e-23
NZ_AP018172.1\|WP_096588071.1\|2010353_2011229_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.37892e-23
NZ_AP018172.1\|WP_096588073.1\|2011870_2012755_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225139	COG2230, Cfa, Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane].	9.3787e-67
NZ_AP018172.1\|WP_096588075.1\|2013334_2014168_-\|hypothetical-protein	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	5.03589e-14
NZ_AP018172.1\|WP_096588083.1\|2020098_2021628_-\|response-regulator	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	3.18676e-58
NZ_AP018172.1\|WP_096588077.1\|2015403_2017170_-\|fatty-acyl-AMP-ligase	gnl\|CDD\|341254	cd05931, FAAL, Fatty acyl-AMP ligase (FAAL). FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.	0
NZ_AP018172.1\|WP_096588079.1\|2018158_2018512_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	8.49074e-13
NZ_AP018172.1\|WP_096588074.1\|2012794_2013106_-\|acyl-carrier-protein	gnl\|CDD\|214834	smart00823, PKS_PP, Phosphopantetheine attachment site. Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.	1.33854e-12
NZ_AP018172.1\|WP_096588080.1\|2018516_2019110_+\|hypothetical-protein	gnl\|CDD\|369506	pfam07767, Nop53, Nop53 (60S ribosomal biogenesis). This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumor suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.	0.000279663

>NZ_AP018172.1|WP_096588080.1|2018516_2019110_+|hypothetical-protein
MQNNLSELQEQEQLRARLEQAQLWEMERARERVQLERARERVQLEQAQQERERERARQAQMDRERMQQVRLKRQARQAREREQARQAREREQVRQAQEREQVRQAQEREQAQQAQEREQVQQAQERERQKSHIKGLLSKILLEEWRGELEALRYGWLKEGKPELWIKIMTGFCLLGLLKAYLQIKVENRWLPKKRQS
>NZ_AP018172.1|WP_096588079.1|2018158_2018512_+|helix-turn-helix-transcriptional-regulator
MSKIRDETDGIRLSALEEDILTLMGTQTMYGLEILDGLNQGRPIPIGFGSLYPTLNRLEKKGLVSWQWGSDQDETGGARRKYYIVTGSGQRVLQEVQDYRYQLRMRSMTGQPGLAGA
>NZ_AP018172.1|WP_096588078.1|2017166_2017907_-|hypothetical-protein
MQILQNLKKELKKLIFAYRFMRIVQLPYGSFGAGGNLSDAAIDPKSLNQIVQFLSRTERGRIALTEKKSLGKIDLQQLHQLPTNTLGYIYADHMLRNGLTPPPVREHTSDTYRYLFNYVMETHDIWHVVTGSNTDKAGEIQVETFSLTQFYPARFWVVLLAKNFLKTAIEDMDLCSQHMEAFVRGWIMGQQAQPLFGVPWNTLWEKPLEEIRAELNIRPYLGSELEAAIKWRGEEITVKSELVGVK
>NZ_AP018172.1|WP_096588077.1|2015403_2017170_-|fatty-acyl-AMP-ligase
MRHIPIDASVTTLVDLLEYRASHQPQQTAYTFLADGITADSSFTYRELHQKAQAIAAYLQSQKAFQERVLLLYPPGLDFAAAFFGCLYAGAVAVPAYPPRPNQSISRLQAIAANAQAKIALTTQAVLALVQPQLQEFADLRSLQWQATDNLNQNWAQDWRRVEVSSDSLAFLQYTSGSTSTPKGVTISHANLLHNSSLIYQSFQHSPESRGVIWLPAYHDMGLIGGILQPLYGGFPVFLMPPMIFLQKPFYWLQAISRYQATTSGGPNFAYDLCVRKITPEQRATLDLSSWEVAFNGAEPVRAETMEQFATLFAPCGFRREAFYPCYGMAETTLIIAGGDKTALPIVEKVEENALKQHQVIPSDNHLDSQNLVSCGQSLANLQVVIVNPETLTPCSPNEVGEIWVSGASVAQGYWDNPEATKDYFHAYLADSQQGPFLRTGDLGFLHQGELFVTGRLKDLIIIRGRNYYPHDIELTVAQAHPSLRVGGGAAFTIERENLVRLVIVQEVERQYLRHLNVAEVVGKIRQAVLQQHELQIHTVALIKTATLPKTSSGKVQRYACREQFLAQKLEILPNLEQSQRVNHLLSA
>NZ_AP018172.1|WP_096588076.1|2014408_2015377_-|acyl-CoA-desaturase
METTVSVESASINRATDLLKKRTMSNSYIKLLQKRHFLLCDVLPFVGFILAIACLWGKPIGVVDIAVFLGMWFLTSVGITVGYHRYFTHRAFQAHPIVRILLVILGSTGAEGPVLSWVANHRHHHRYSDEVGDTHSPHLHGTGWRNQLYGFWHAHLWWKVEYDYPNPLYYAPELLRDKTICKLNQLYFVWVILGLVFPAVVAFILTGNWIGTWYGFLWGGVIRLYLGQQTTWCINSICHLFGTRAFDTKEKSTNNLWLALPTFGESWHNNHHAFQNSAKFGLQWWQIDIGYWVIVALQSLGLAWDVNQPTPEMMQSKSVRSL
>NZ_AP018172.1|WP_096588075.1|2013334_2014168_-|hypothetical-protein
MFVLASLIVGNILPCFVFFAHDLSHGSVITKSWQRHFLEVLIWGINFIPLTMWIHIHHRTHHLNAATFKDPDRRWLASEKTLIKSIYTWIFYPQKNKLLIRFINPFAYIHFVFYILRNFIAVFISPKSKLYIVPYQVPYTFKEKFSIIIETSIIILIQTIIFVAVQCNWLKYLFVGILPILMASMIEVIYVATNHFLNPVKAQNNSVQGTTSVIVPPFFNLIHNNFSYHTEHHLFPAMHPSYYPLVSDLLKKHFPQDYNQLTITEAWRRLWNSQAFD
>NZ_AP018172.1|WP_096588074.1|2012794_2013106_-|acyl-carrier-protein
MELTSTIANNSLESQQNTLSAEVIQESIVAYIAELLEVEPHQVNVKARFNEYGLDSLSSVSLISHLESLTGQDLSPTLLYDLPSVEVLSQRLASGITKLEIAL
>NZ_AP018172.1|WP_096588073.1|2011870_2012755_-|class-I-SAM-dependent-methyltransferase
MTTAKTLTPGASHEAIQHHYDVGNDFYQLWLDSTMTYSCAIWDEGEPEEALELAQIRKVDFHINQAKAKNAKRVLDIGCGWGTVLKRLVDVHGVEQAVGLTLSEAQKNWISANKHPQIEVNLESWLNYSPKEPFDAIISIGAFEHFVKPELSSQEKIDVYRTFFSRCHEWLNPGGSISIQTIAYGKRKPEEVQKSLGAQFANQEIFPESDSPRLTEITAAAEGIFEVVSVRNDRMDYVRTLQAWLTNFRSKRTEIINLVGKTVFERYERYLYLALLGFLTGDLLLLRLTFRRID
>NZ_AP018172.1|WP_096588072.1|2011323_2011827_-|lipocalin-like-domain-containing-protein
MFNKVTNNLVGTWKLLSCETRTANGQVFYPLGDNPSGYIIYTDNGYVSVAMMKANRPLFQAGDIAAGTVEEKVTAADSYVSYCGTYEIQDNRVVHHVEVSFFPNWVGANQVRFLQLNDDLLTLSTHPILVNGIEIVGSLIWQRVSDIKPEKELVTSYPVKELSLRTK
>NZ_AP018172.1|WP_096588071.1|2010353_2011229_-|alpha/beta-hydrolase
MSQYIEVGEHRLTALGANQNQPGIPIIFLHGITLSANFWIANLPAIIRDNLPWYSLSLPGHYPDFYQPELLTADMLADILMSAIHKLVGKQPVALVGYSTGGFAALNLAANFPEQIKGVFCISGFSQAQWQGFLGWLQRLTHNGAMGKLVCKILCKALMLNQTSYKLGCSMNAGDRAAYWNAPTLQTTVDAVYPDVIKHNLNNIVDLFEWFANMDISSLLPKIQAPTLILSGDRDPIIPLAHAKFLASQIPDAELIVLQGMGHLFFAERSLAYQNLLTSWIIEKKLCISEQ
>NZ_AP018172.1|WP_096588081.1|2019237_2019426_+|hypothetical-protein
MLNSILNGLVCSSTEPENPKEDSAKKKTPWDWRKLIELVKDVGSVVSVVISLLKILQDLGLL
>NZ_AP018172.1|WP_096588082.1|2019600_2019993_-|response-regulator
MSRNILIVDDEEDVQAIAKLGLELGAGWNVLTACSGREALNVAANSQVDVILLDMMMPDMDGRATLQKLKANPVTQQIPVILLTAKVQESEQDCFTGLDVAAIFAKPFRPLKLAGQISEVLGWAYSEIES
>NZ_AP018172.1|WP_096588083.1|2020098_2021628_-|response-regulator
MSKQLSNSPKADILVIDDTPENLNLLSAMLTEQGYKVRSVTKGSTGLRGANAVPPDLILLDVNMPEMNGYEVCQQLKTSDRTRDIPVIFISALGDVLDKVKAFAVGGVDYITKPFQLEEVLARIENHLTIRQLQKQLQAQNQQLQQEIRNRTKAEEKFAKVFRSSPNPIAIATISEARVLDVNPSFLKMSGYCLEEVIAHTIEELDLGKNTVAIAQTIQNLPDSGSLYNLEFEFSTKSAEIKTILLSIELIDLAGVPCALLIANDITERKRLENEFISLVSHELRTPLTSTMGALDLLSSGQLGTLSAQGQKVLSIASNNTERLIRLVNDILDLERMKSGKIFMRMARCNATELLITATEAMQAMADKLQVKLIVNPLTVELWADADRLMQTFTNLLSNAIKFSEPGDTVWVSATLSENHGVESQQDTPSYLLITIRDEGRGIPEDKLQIIFERFQQVDASDSRNKGGTGLGLAICRNIVQQHNGKIWVQSVLGEGSTFYVLLPLAVSN
>NZ_AP018172.1|WP_096588084.1|2021820_2022363_+|hypothetical-protein
MTNQQISSLPKTARLFAALGLTLSTSLFVYPSASQAGKGGAIPAELQGEWLYGRISSIQYQDQITGQSAAPNGSSDRFIVAANGNYQRRRLIQINTYNCASNLFIQEKGTVSVDDRQLTFQPTESSSKGQICNSGRTYTGNNTAKPETYKWSIAKNDSGQDVLLLETADGQGQAHYGRPQ
>NZ_AP018172.1|WP_096588085.1|2022443_2022926_+|hypothetical-protein
MIHHISFAVNNPYHVAQVLAEILKAEAVPFPPHPGSYMVIPFDEHGTAIELYPSGTQLEPGEGDGQCAFVQNAISPKFVDIHAAISVPASQEEIEKIGDREGWRTLRCTRETFFDVIEFWVENRLMIELLTPEMATQYVKFTTHPETRRIFTAEPALVTA
>NZ_AP018172.1|WP_096588086.1|2023065_2023284_-|DUF4351-domain-containing-protein
MEIVTSWQLPGRQEGKQELIMRLLNRKVGTLTPKLEEQIRQLPTTQLEDLAEALLDFTNAEDLVAWLNGVAG
>NZ_AP018172.1|WP_096588087.1|2023324_2028022_-|PAS-domain-S-box-protein
MSAEQLEQVKLLQATLTKMEVTLGAIADAVVWVGKDGCVQWCNSSFECLLNRPQSAIANWQLSEVLPLLQLGKPVALNSYPDVLIHNGEYETTEYEFHQGKRSLVLQISGSRAGLNEDDCAVLVIQDITLAQEAQKSLQESEERLRTLINATPDIICLKDSEGKWLESNQANLEFLEIQGVDFKGKTDSELAQFSDFYHDTLLNCHQTDEQAWQQGSVHRVEEVVPRPDGTLSIVDMIKVPVFHQDGRRKALVVLGRDVSDRQKTQIALENSLSLLSAILESIQDGILAIDSLGNITSYNQKFLEMWSIPPELLTEPDRSKRLAYLANQLKDPEGFLQRVRELYAQPELDSYDFLELQDGRVFERYSCPQRIKDQIIGRVWSFRDVTQRQKAEAALRQSELQYRSIFEAINDGLFITEIETETVAEVNPAACQMHGYSYEEFIALHPSAYIHPSSHQVFHEFVEITRAGGQFYGQAVDVCKDGSLIDVEVKGTTCIYNGKRHILAIVRDISDRKRTEAALRQSEVQYRDLVQTANCIILRWDSHGDIIYLNDYGQKLFGFDAQEIIGRNVVGTIVPETETSGRDLQALMVDICQYPENYLFNENENSCKNGDRVWIVWANKPILDEQGNLIEILSVGTDATERKRAQAALQESELKFRTIVENANDLIFTISPEGIFTYHSPNVTPIMGYSLPEIEGHSVAEFTYPEDLAISAAGIQKAIAGEKQTGIEVRLRHKNNSWRWFSFNTSTINTPDGGIAIAGVGRDITERKQAEEALRRSEMKYRNIFENSQVGIFRTRQQDGLIVDANQRGADILGFAAANELIGKYFTTELYVNPDDRTRMLAELKASGEVRNFEVALRRCDGSVVWVLLSIRLNAEESCLDSVFTDISDRKQAEQALQHRAQLESILSSISRQFIDQDVDTAINFTLKAIARFINAEHSCIFECSEDQSEFYLIHEWCSQGVPPLINIAKGSPVETFPYFYEPIIRGKHRQISSVADLPPHLPERQLFESMSFQSLIAVPMLHAGTVVGFVGLAMIHFSKTWSQDDINLLKLVGEIIAIGRARHQAEAALRVAKEAAETANRAKSAFLANMSHELRTPLNAILGFSQLMERDTSLNSNQRESLATINRSGEHLLNLINDVLEMSKIEAGHIVFNPEDFDFYLMLQTLQEMFQVRAQTKQLYLKFEIAPDLPRYVQTDEGKLRQVLINLLGNAIKFTQTGGVTLRARLGDEGDEGDKENNYKSMPHAQSLIFEVEDTGRGIAAAEMNNLFQPFVQTTSGIQTKEGTGLGLTISRQFVRLLGGDIHLKSTLGQGSTFSFDIQVNLATPIKVTPKLSRGRVLKLAADQPTYRILVVDDRKENRDLMMQLLGGVGFEVEPASNGQEAIAMWQKWQPHLIWMDMRMPVMNGYDATKEIRARERSLDNRSRTVIIALTASAFEEQQASILAAGCDDLIRKPFREQIIFEKIAEYLHLSYIFSEENSEIKTDNKLDNVQYSVLDIRTAITIMPAEWIAELNQAAIAVDADRILQLIEQIPLTHSGLAEKLANLVRSFCFDEILELTSNLFK
>NZ_AP018172.1|WP_096588088.1|2028221_2028479_+|hypothetical-protein
MDINIQIDRLILEDINISPSQRRHLQSTVESELSSLFTANGLPSHLHNGAAFPSLPLGKVEVTNTTDTTVMGQQIAQQIYSQLIQ
>NZ_AP018172.1|WP_096588089.1|2028709_2028946_+|hypothetical-protein
MMTFIYLLFVLPFIITFIIGFFSYKPEPGTIPGQSAETNGTIIPAELLQQLQKAGYIDADGKLKLLNFVLDFMTHGNS
>NZ_AP018172.1|WP_096588090.1|2029250_2029715_-|hypothetical-protein
MSALEYIEDIASELKQTLSAPDTGKIYLRAIVKTWQLIKQLARLIFLLVLLFIAFTIWVWNLGFKSGYKLRQQLETEQTSPQNLLQQTINLLVSLLKGIVDWAECQISQLPSEKTKIQVIPPAPANHSANLITPAKNQTTTIDLTNIQQKKLSE

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Crispr_ID: NZ_AP018172_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_5

2447850-2448152

Orphan

Consensus_repeat	Method
TGCACTCCCACTGCGGCGTGCAGTGGGCGATAGACGTGGCGAAGCTACTACATTGACTAATAT	PILER-CR

2 spacers

The CRISPR arrays of NZ_AP018172_5

>merge|NZ_AP018172|5|2447850-2448152|PILER-CR
TGCACTTTTACTGCGACGTGCAGTGGGCGATAGACGTGGCGAAGCTTCTACGTTGAGTAATATTGGGCTAGTTTACTCAGATTTAGGGGAAAAACAGAAAGCTTTGGAATATTACAACTCTGCACTCCCACTAAGGCGTGCAGTGGGCGATAGACGTGGCGAAGCTATTACCCTAAATAACATCGGGGGAGTTTATGACACTTTAGGGGAAAAGCAGAAAGCTTTGGAATATTACAACTCTGCACTCCCATTGCAGCGCGCAGTGGGCGATAGACGTGGCGAAGCTACTACATTGACTGGTAT

>NZ_AP018172|5|5|2447850-2448152|PILER-CR
TGCACTTTTACTGCGACGTGCAGTGGGCGATAGACGTGGCGAAGCTTCTACGTTGAGTAATAT	TGGGCTAGTTTACTCAGATTTAGGGGAAAAACAGAAAGCTTTGGAATATTACAACTC
TGCACTCCCACTAAGGCGTGCAGTGGGCGATAGACGTGGCGAAGCTATTACCCTAAATAACAT	CGGGGGAGTTTATGACACTTTAGGGGAAAAGCAGAAAGCTTTGGAATATTACAACTCTGCACTCCCATT
GCAGCGCGCAGTGGGCGATAGACGTGGCGAAGCTACTACATTGACTGGTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096588407.1\|2435605_2436958_+\|cell-wall-hydrolase	unknown	unknown	gnl\|CDD\|223929
NZ_AP018172.1\|WP_096588417.1\|2452560_2454858_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|100081
NZ_AP018172.1\|WP_096588418.1\|2455073_2455565_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588422.1\|2459434_2461279_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_AP018172.1\|WP_096588423.1\|2461470_2463291_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_AP018172.1\|WP_096588408.1\|2438437_2440027_+\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|236507
NZ_AP018172.1\|WP_096588412.1\|2442766_2445967_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|206741
NZ_AP018172.1\|WP_096588410.1\|2441683_2441899_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588414.1\|2450306_2450936_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_AP018172.1\|WP_096588404.1\|2431683_2432949_+\|plasmid-pRiA4b-ORF-3-family-protein	unknown	unknown	gnl\|CDD\|377943
NZ_AP018172.1\|WP_096588420.1\|2456611_2457697_-\|spermidine/putrescine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270308
NZ_AP018172.1\|WP_096588403.1\|2430982_2431534_-\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226104
NZ_AP018172.1\|WP_096588411.1\|2441891_2442308_+\|retroviral-like-aspartic-protease	unknown	unknown	gnl\|CDD\|133136
NZ_AP018172.1\|WP_096588405.1\|2432986_2433442_-\|DUF3592-domain-containing-protein	unknown	unknown	gnl\|CDD\|378822
NZ_AP018172.1\|WP_096588419.1\|2455657_2456575_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097
NZ_AP018172.1\|WP_096588409.1\|2440036_2441485_+\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|376743
NZ_AP018172.1\|WP_096588421.1\|2458094_2459222_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_AP018172.1\|WP_096588416.1\|2451967_2452501_+\|phosphohydrolase	unknown	unknown	gnl\|CDD\|237176
NZ_AP018172.1\|WP_096588415.1\|2451235_2451829_-\|transposase	unknown	unknown	gnl\|CDD\|224854
NZ_AP018172.1\|WP_096588406.1\|2433486_2435427_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096588407.1\|2435605_2436958_+\|cell-wall-hydrolase	gnl\|CDD\|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	6.04207e-32
NZ_AP018172.1\|WP_096588417.1\|2452560_2454858_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	2.4958e-33
NZ_AP018172.1\|WP_096588422.1\|2459434_2461279_+\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_AP018172.1\|WP_096588423.1\|2461470_2463291_+\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_AP018172.1\|WP_096588408.1\|2438437_2440027_+\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	gnl\|CDD\|236507	PRK09424, pntA, Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha.	0
NZ_AP018172.1\|WP_096588412.1\|2442766_2445967_+\|GTP-binding-protein	gnl\|CDD\|206741	cd09914, RocCOR, Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family. RocCOR (or Roco) protein family is characterized by a superdomain containing a Ras-like GTPase domain, called Roc (Ras of complex proteins), and a characteristic second domain called COR (C-terminal of Roc). A kinase domain and diverse regulatory domains are also often found in Roco proteins. Their functions are diverse; in Dictyostelium discoideum, which encodes 11 Roco proteins, they are involved in cell division, chemotaxis and development, while in human, where 4 Roco proteins (LRRK1, LRRK2, DAPK1, and MFHAS1) are encoded, these proteins are involved in epilepsy and cancer. Mutations in LRRK2 (leucine-rich repeat kinase 2) are known to cause familial Parkinson's disease.	2.77299e-75
NZ_AP018172.1\|WP_096588414.1\|2450306_2450936_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	4.96472e-118
NZ_AP018172.1\|WP_096588404.1\|2431683_2432949_+\|plasmid-pRiA4b-ORF-3-family-protein	gnl\|CDD\|377943	pfam07929, PRiA4_ORF3, Plasmid pRiA4b ORF-3-like protein. Members of this family are similar to the protein product of ORF-3 found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process. Other proteins found in this family are annotated as being putative TnpR resolvases, but no further evidence was found to back this. Moreover, another member of this family is described as a probable lexA repressor and in fact carries a LexA DNA binding domain (pfam01726), but no references were found to expand on this.	6.21978e-25
NZ_AP018172.1\|WP_096588420.1\|2456611_2457697_-\|spermidine/putrescine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270308	cd13590, PBP2_PotD_PotF_like, The periplasmic-binding component of ABC transporters involved in uptake of polyamines; possess the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain that functions as the primary high-affinity receptors of ABC-type polyamine transport systems. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.77401e-125
NZ_AP018172.1\|WP_096588403.1\|2430982_2431534_-\|nucleotidyltransferase-family-protein	gnl\|CDD\|226104	COG3575, COG3575, Uncharacterized protein conserved in bacteria [Function unknown].	1.45524e-66
NZ_AP018172.1\|WP_096588411.1\|2441891_2442308_+\|retroviral-like-aspartic-protease	gnl\|CDD\|133136	cd00303, retropepsin_like, Retropepsins; pepsin-like aspartate proteases. The family includes pepsin-like aspartate proteases from retroviruses, retrotransposons and retroelements, as well as eukaryotic dna-damage-inducible proteins (DDIs), and bacterial aspartate peptidases. While fungal and mammalian pepsins are bilobal proteins with structurally related N and C-terminals, retropepsins are half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Retroviral aspartyl protease is synthesized as part of the POL polyprotein that contains an aspartyl protease, a reverse transcriptase, RNase H, and an integrase. The POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.	9.16837e-06
NZ_AP018172.1\|WP_096588405.1\|2432986_2433442_-\|DUF3592-domain-containing-protein	gnl\|CDD\|378822	pfam12158, DUF3592, Protein of unknown function (DUF3592). This family of proteins is functionally uncharacterized.This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.	2.19909e-25
NZ_AP018172.1\|WP_096588419.1\|2455657_2456575_-\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	2.95356e-85
NZ_AP018172.1\|WP_096588409.1\|2440036_2441485_+\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-beta	gnl\|CDD\|376743	pfam02233, PNTB, NAD(P) transhydrogenase beta subunit. This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.	0
NZ_AP018172.1\|WP_096588421.1\|2458094_2459222_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	3.52741e-162
NZ_AP018172.1\|WP_096588416.1\|2451967_2452501_+\|phosphohydrolase	gnl\|CDD\|237176	PRK12703, PRK12703, tRNA 2'-O-methylase; Reviewed.	2.95566e-05
NZ_AP018172.1\|WP_096588415.1\|2451235_2451829_-\|transposase	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.84064e-09
NZ_AP018172.1\|WP_096588406.1\|2433486_2435427_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0

>NZ_AP018172.1|WP_096588412.1|2442766_2445967_+|GTP-binding-protein
MTQDELLLLIDRAVAEGWRELDLSGQKLTKLPGEIGKLQQLESLILGKKVEGYEKVGTHYFEKVSGNNLKTLPFELLGLPNLRKLDISGNPLKNIPNVVTQILNLEELILIRVELTEIPEAIAKLTNLTQLDLSSNQITKIPEVFANLNNLTQLFLTDNKITQIREALAKLTNLTKLSLHNNQISQIPETLANLTNLTQLFLGCNQISEIPETLTNLTNLKELYLFQNQISEIPETLAKLTNLTKLILSNNQISEIPEALAKLTNLKQLDFSDNQISEIPETLAKLTNLSRLDFSGNPITQIPEVLAKLTNLKGLDLSGNQITEIPEALAKLTNLSRLDLSGNQITEIPEALANLNNLRELDLSGNQITEIPEALANLTNLRELELRGNRITQIPLEILNSTDAKEIFNYLRQIRISETRPLHEAKLLLVGQGSVGKTSLIKRLIHNKYDQNQPQTDGLNVQTWNVQVNSKNIRLNVWDFGGQEIYHATHQFFLTKRSLYLLVCNCRTSEEENRIEYWLKLIESFGGQSPVIIVGNKKDEQPLDINRKALREKYPNIQAIIETSCQDNIGIDELRAAIFQQIANLKEVYDFLPLSWFEVKQQLESMPQDFITYNRYIGICHENKIPEEQNQEQLIDLLHRLGLVLNFREHPILKDTNVLKPNWVTEGIYTLLSDEILKTKTKGIFTHADLTRILNPKRYPTQRHGYLTGLMKEFELCFALECQQPQFLIAGLLPKDQPDETELEGETLEFQYHYKVLPESIISRFIVITHEKIHNQIYWRSGVMLRYQEHNEIYNIARIKADPEDKKIFITISGRKETRRLFLGILRDVFNKIHKSLPNLEITEWVPVPGYPNHPPLDYQELLGLEAMGESTVPIGKLKLKLDLRQLLDGYESLEARRKSQKAEPESGFTIVNQIYNNNHGEFKPMTQNTNNFQNPNIANFANEVKDNASQQASNFNQTSGANINEILQLISNLRQTAAQFPPEIRDDITIDNKITNIDRVINDIEVEIQKPEKERNTPELRKRLTALLTAATVAAAPIAGMTDFANNVMEIGSKLNIELKLPPVK
>NZ_AP018172.1|WP_096588411.1|2441891_2442308_+|retroviral-like-aspartic-protease
MVNAQRFAFIEGRDAFGDIDAVPQLPLTLAYRSSIVEVRGLLDTGASINVLPYSLGIQLGAVWEELNTSVQLAGNLAPVEARGLVLSAQIGTFAPVRLVFAWSLTDNVPLLLGRMNFFLEFDVCFYRSQMAFELRPKS
>NZ_AP018172.1|WP_096588410.1|2441683_2441899_+|hypothetical-protein
MNITELFPTLRNLSRAEKLQVMQFLVQELADEEALSLQPGATYHVWSPFNSHDAAVKLAALLQEDRQASDG
>NZ_AP018172.1|WP_096588409.1|2440036_2441485_+|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-beta
MSNNLLTVAYIVASALFILSLGGLSDQETARKGNVYGIVGMVIAFVATALSLDMNAYGILGTVVIPGAVIGAIVASRVAMTSMPELVAILHSFVGAAAVLVGIANYLQETRSLTPVESTIHQIEIFVGVFIGAITFTGSIIAFGKLRGIITSKPVLLPARHFLNLSILVASIWLGSQFIGAEATTGLQPLLIMSAIASVLGIHLVMAIGGADMPVVISMLNSYSGWAAAAAGFMLSNDLLIITGALVGSSGAILSYIMCKAMNRSFISVILGGFGAQTTTTTDSAQPEGKVNSTTVEDTVEILSRAKSVIIVPGYGMAVAQAQHGVSEIVKRLRDRKIKVRFGIHPVAGRMPGHMNVLLAEAKVPYDIVLEMDEINEDFPETDVVLVIGANDTVNPSALENPNSPIAGMPVLEVWKAGTVIVMKRSMASGYAGVENPLFYKPNTLMLFGDAKKNIDATVGKLTELSEESVNLNLAVKPAFST
>NZ_AP018172.1|WP_096588408.1|2438437_2440027_+|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha
MKVGIPKEVYPDEHRVAATPETAKRLQKLGFDVLVERNAGRGANFADDAYTQANCQIVPDAPSLWAEADIVLKVRPPQMHPDECKHEADLLHPGSTLISFIWPAQNPDLLQKLVARQSTVLAMDAIPRISRAQKLDALSSMANLAGYRAVIEAANHFGRFFNGQITAAGKVPPAKVMIIGVGVAGLAAIGTAKGLGAIVRAFDTRLVVKEQVESLGAEFLELNFAEDGSGEGGYAKVMSDEFIKAEMELFAEQAKEVDIIITTALIPGKKAPVLITQEMVESMKEGSVIVDLASEQGGNCACTHPGEIYRYKGVTIVGLTDFPSRMAQQASQLYGTNLYHLLEDMGGAKNFQVNLADEVIRGALVVHGGEITYPPPKVEKKVEVTENKTSKSEDKVKEQVPVLATAPASPVPSTAKSGSNLIWLLLVGIALFGIGISAPPEFLSHFIVFVLACFIGWQVIWNVKPALHTPLMSVTNAISGIIIIGGMLQISGGSSSYTTILGAIAILVGTINISGGFLVTQRMLKMFQK
>NZ_AP018172.1|WP_096588407.1|2435605_2436958_+|cell-wall-hydrolase
MGRIFISAAHGGKEAGGIDPGTIAGGTTEAREMILLRDLIVTELRARNFEVLSVPDDLSAADTIAWINSRGRSTDVALEIHADAASNPSVRGASVFYIANNNQRKSNAELLLVGLLRRVPQIPNRGVKPDTDSGLGRLIFCRQTAIASLLMQVGFLSSPEDRALLQNRRRDFALGIADGLASWSRAIDPNQGTPSEPTYPPINININGQKYSEQGILINGNAYIPIDLVDRLRVDLSKIPEVRRITYHKVVYVKAIELRDFNVSVGWDAATRTVSLRSILVVCSGQFDRIVSNGNTSEVELQVFLRNNNENALVKFPDIPKLYREEASTEGINYDIAFCQMCVETGFLRFGSDIKPEQNNFAGLGTIGGSSQAASFESARIGVRAHIQHLKAYASLEPLVNEVVDPRFRFVTRGIAPLIDQLSGRWSADLDYGAKITAMLKRLYESAKLL
>NZ_AP018172.1|WP_096588406.1|2433486_2435427_-|DNA-primase
MQIPRLHPDTIEEVKQRADIVDVISEYVVLRKRGKDFVGLCPFHDEKSPSFTVSQTKQMYYCFGCQAGGNAIKFLMDLGKRSFAEVTLDLARRYQVPVQTLEPEQRQELQRQISLREQLYEVLASTAHFYQHALRQSQGQKALQYLKSDRLLQEETIQQFGLGYAPAGWETLYRYLVDSKHYPVQLVEKAGLIKPRKEGGGYYDVFRDRLMIPIRDVQGRVIGFGGRTLSDEQPKYLNSPETELFSKGKTLFALDLAKAGISQLDRAVVVEGYFDAIALHAAGINNVVASLGTALSLDQVRLVLRYTDSKQLVLNFDADAAGTNAAERAIGEIAELAYMGEVQLKILNIPDGKDADEYLHSHTPEDYRQLLTNAPLWLNWQIDRIIKGRDLKQPTDFQQATQQIVKLLKNIVNNDTRNYYISYCAEILSLGDSRLIPLRVENLLTQIAPANSYSQPVPIKRKWESGGSSQTSVAKSQSTVVASDRGLLERAEGLLLRIYLHCPEQRQVILDTLEERDLQFSLSHHRFLWLQIVEVPGGMEVDLVSTLQDKYLEFTDEMRLISHLFHLNEKSQKEILRTPQVVQAAIACMERVLREKRYRHFLELWQETDPEAEPEQWQSYYQAFYNEKLRLQELDRQRQFSITDLL
>NZ_AP018172.1|WP_096588405.1|2432986_2433442_-|DUF3592-domain-containing-protein
MDDSKFFLLFGSIFAGIGSIFAVTGIIFVINTNSFVRTAESIQGTVIDLKLRSSTDSKGRHSSAYYPIVRFTPSSGEPIIFESHTGSKPPSFTKGQQVEVLYHPQKPDSTTINSWFELWFLPTMFTGLGSIFVLVGGSVLVIPFRRWVSLK
>NZ_AP018172.1|WP_096588404.1|2431683_2432949_+|plasmid-pRiA4b-ORF-3-family-protein
MEDLFARLERTLTPELPSLTESQQQLLKELSIDENQPGTILRDFQTLIDFLQPKGVEVSSVNNLLPLKVLSELNLRLSHPIETKLKRPVQKSYPYINGLYLLLRSSGIAQLKSQGKKQILVLDEAVLAAWSSLNLTERYFTLLETWLIWGNNETIGERQDVWNNLFKCIQFWARVSDKGLKFAKYEDQNDVSYYPGLHNIALLELFGLLTIKQGKPQEGKGWRINSVQRLPLGDAVFRLLFSIGMLGKFEDEVDINFGKLQPNFQPYFPEWERNLTLPKQGFNDGIYIFKVSVSKSWRRIAIPAKRQLSSLASIILDAFDFDYDHLYEFIYKDRFGRICKIGHPYLETPPFADRVRIGDLPLEPGASMTYLYDFGDNWEFNVQLEAIEPPDNKIKKAKILEIHGDAPQQYWSEDDDWDEEE
>NZ_AP018172.1|WP_096588403.1|2430982_2431534_-|nucleotidyltransferase-family-protein
MNSNTRLQKILADTPVGMILPAIAQLNLPDWWLAGGAVRNTVWRSIFGNDCELVIKDFDIAFFDIQGNRSQELAAKAILTEQFPNDMFDVKNQASFARWRPGRRTYNSTEDGIKEWLHTATAVGVRLDAQGQWQFFTPYGLDDLFSGIIRTTPVHTYNPNAHQKASGFLQKCPYLQLVQSNSI
>NZ_AP018172.1|WP_096588414.1|2450306_2450936_-|recombination-protein-RecR
MVKVKHSGDKATVYARPLARLIEQLQRLPGVGPKSAQRLALHILKRPETEVEALAQALIDAKKQVGLCSVCFHLSAEPVCEICRNPSRDINTICVVADSRDVIALEKTREFKGKYHVLGGVISPMDGIGPEQLTVQALVRRVSQQKPQEVILAISPSVEGETTTLYIGQLLKPFTKVTRIAFGLPVGGDLEYADEVTLARALEGRRELD
>NZ_AP018172.1|WP_096588415.1|2451235_2451829_-|transposase
MYQYRQLTQEQKIALVQERLAKGYPPHSPPHPIENSQFYLITATCYEHKHRINSKERRQQLLNQLFEKFTYQDIEILAWAVLTNHYHLLLENINFKLLSKILRSIHGSIARQWNLEDNLTGKLWCSYSDRAIRSKRHYYTTLNYIHYNPVKHSCAKSPYDWDESSVHWYLENYGRDWLRSCWIEYPLRDYGKEWDDL
>NZ_AP018172.1|WP_096588416.1|2451967_2452501_+|phosphohydrolase
MSSQIRNFSTVHDAHKFLQQLGASSKLIRHVKLVGEAAELLIAKLHQLPVSFNAGFVRLGVAFHDAGKILHPEELTAKGNNHELAGEQLLIAHGVEPSLARCCRSHGQWESMECSLEELLVALADTLWKGKRISQLETMVIERLSALCKRDYWELFVEMDSCFEAIASEGDLRLSRS
>NZ_AP018172.1|WP_096588417.1|2452560_2454858_-|tetratricopeptide-repeat-protein
MQYLLYPIAIYVFLLFIRYFITFLQLCKSQFQYPKYQVTQAETVPSYLRDLFQSPIQELEQLGFQPLSYLAYQPMVKVYQSTSWEILLYNKAFKSYASVAVRRLVEPVNLYDIEYYTFFKEQTLLLTVNGKAHGLIGEIPNTIVQDVYTDLVSVQWQTHQERLNQLTASKTPLGLLPEAFAKALQIYMGNYVNYLVKTKYISPIKGTELFQLNWLPALKIVNSIIRSGNKVANIIKQRKQKAKTDASLSKEIPIELEVEGFQQMQYLQQGLVGKKFRTWLLLGSLALFIASYTHYLNAQSVGIFICVLLFHEGGHLLAMKLFGYRDTSVLFIPFLGALATARKDDATLTQKFWISLAGPLPGLILGIGLAILAPANSGYPGWVREASWTLIFLNLFNLLPVYPLDGGQIADLLLFSRFPYIGVLFKVIGVIILGSLGKDRPEMLLFVFLVALSIPYSFRSAKINTKLHKELQQNPPRNADNLLHAIFKYLQKFGYGNLPFNTKYTLVKELIQKHHESSGKRTTRVFLVIVYCMSLFGGIAGSFQAILPNWVSVLPYYFENSQQRRERYIKNREKAVEEATAVIRSNPNDVNAYIKRSRAYLALSDRQGALADYDQVIRLQPHNIEYRLTRANLRRWLKNYQGAIQDYNEVLRLQPKKAYVYQLRAQVRDEMQDYKGAIADYNEMIKSNAQDTWAYISRGYARQKLQDYKGAIADADYVIKLNPKNPEAYVLRSQVRHRMGDTQGAIADKQTAHNLYKTMYEEDPT
>NZ_AP018172.1|WP_096588418.1|2455073_2455565_-|hypothetical-protein
MRLPIFISAGLLLTLSLNAPVVSQTPIPAPQTRPIANSQLNQLNINRQLWKKQNIRNYRYKFSRSCFCAPKASGPVVVKVRQGRTTSMTDAAGKPIERELFQQYDTIPKLFNVIEDAIAKKASSLTVQYDPKFGYPTQINIDYNSQMADEELYLTIEGLQKIR
>NZ_AP018172.1|WP_096588419.1|2455657_2456575_-|ABC-transporter-permease
MNQQTSETQFNSESDIAKIQKLHSSNFSWLQPLILLAPAGIWLLLLLVLPTLIIFELSLVPDIRPGDLVNPSGLQNYLRIFDPLYLQVILRSISLASVTTIICLILSFPVAYWIALIAPKRWRNLLLLGFILPLWTSSLLRSYAWITILRPTGLLNTLLKGLHLQPLELLNRTPSVLIAMSYSLLPYMVLILYASLEKLDTRLLEAAADLGANPRQAFWKVTVPQILPGLTAGSILVFITGLGDFINPELLGGASSMTAARLVYNQFLGATQNWGFGSALSMTLILLVSIAIALVIKFGEATPKR
>NZ_AP018172.1|WP_096588420.1|2456611_2457697_-|spermidine/putrescine-ABC-transporter-substrate-binding-protein
MTKRRKFLQGITALSSLSLAGCGWRLADVRANAKTSGQRDQLYIYTWTQYTDNQLLKTFSTQTGMKILADVYDSNDVMLAKLQAGGGSNYSIIYPSDYMVQKMVEKDLLIEINHDRLIGLENLFPRFQNPTYDIKNRYSIPFNWGTTGIVYNSEILQDAPEDWDYLWQNQEKLKKRMTLLNDVREVMGAVLRMLGYSYNSQDETQIKQAYEKLKELKPGITAFDTEAWQNQILAGDLVLAMCYSADAIRVSKENPKLKYVIPRSGSSLWTDTIVIPKTAPNVDGSYAWINFILQPEVAAQISQRLNIATPNLSGFEQLPIRLQQNTSLFPPDSILEKCERISPLGKFDEVYDRYWTQLTSS
>NZ_AP018172.1|WP_096588421.1|2458094_2459222_-|ABC-transporter-ATP-binding-protein
MAQTVTQNQGEMMALQPLDVELRNVFKFFNQEPAVNGVDLDVRQGEFFSILGPSGCGKTTILRLIAGFEQADAGKVLIQGQPMTNVPPYRRPVNTVFQSYALFNHLNVWDNIAFGLRLKKFRKPEIDRRVKEALKLVKMESLRSRFPNQLSGGQQQRVALARALVNRPSVVLLDEPLGALDLKLRKEMQVELINLHKELGLTFIMVTHDQEEALSLSDRIAVINQGKIEQVGTPSQIYEFPRTAFVADFIGDTNLFSGEIVAVEASTVQIETKTGLKIIVNRNEETPTEISQSVVVSVRPEKIQLSLYPPNLPNNCFEGRLVNIMYLGTHVNYVVELINGISINVLQPNTFGSLPDANTPIYAWWAGSDCLAISQ
>NZ_AP018172.1|WP_096588422.1|2459434_2461279_+|penicillin-binding-protein-2
MAFLPSSLPGSKKDTRTVGRGFQSIFLIAFTLVMTAGIDARLAYLQIVEGPKLRQRAESNRIRMIAKQPERGNIFDRNGKLLASTRYPHSVYLWPMAHTKPSWSVVAPRLEKILNITQDEMEKKLKQAGANSSSLIRIARDISEAQITALKEYANELPEVEINTEAVRYYPHGAALAHVLGYTRELTAEQLKDKKEEGYRLGDVIGQMGVEKAYEKTLRGEWGGQQVEVDGAGRPIRVLGEKQAKAGNDLHLTIDLNLQKAADQALGKYQGAVVAIDPNNGAVLAMASHPTFDPNIFSKQKLSQKDWESVQGKDHPLVNRSLSAFPPASTFKIITASAGLETGKFSPDTVLQTFGSLTVGGVTFGEWNHAGFGPLGFAGALAMSSDTFFYQVGRKVGGPDLIAWSRKYGFGQKTGIEFANEESKGLVPDENWKQKAWKMPWTVGDTINMSIGQGALQVTPLQSAIMFSVPANGGYRVKPHLLKDHEEAKSWRVSLNMKPSTIKVLREGLRKVVSDGTGKRLNVPTIAPASGKSGTAEAGVGRPNHTWFGAYAPSDKPEIVVVAFGENSGDHGGTVCGPMALQVLEAYFQHKYPGKYQKSESEGKNQNGGGSTGD
>NZ_AP018172.1|WP_096588423.1|2461470_2463291_+|penicillin-binding-protein-2
MALLQPSPFGNQKNTRTVGRSFQPIFLIIFTLLMTSAIGARLAYLQIVEGSNHRKRAESNRIRMIPKQPERGNIFDRNGKLLASTRYPRSVYLWPMAHTKPSWPVVGARLSKILDIPQAEIEKKLEEAGRNSSSLIRIARDLDEAEITALKEYQSELTDVEIHLDAVRYYPHGKAVAHVLGYTRELTAEQLKDKKQDGYRLGDVIGQMGVEKAYEKSLRGEWGGQQVEVDGAGRPLRVLGEKQAKAGNDLHLTIDLEMQKTAEKALGDRNGAIVAIDPKNGAVLAMVSHPTFDPNIFSKQKLTQKDWESVQGAEHPLVNRALSAFPPASTFKIVTTTAGLESGKFSPNTVLQTYGSLNIGGTTFGEWNHAGFGPLGFVGALQWSSDTFFYQIGRAVGGPTLIEWTRKYGFGEKTGFEFASEETKGLVPDETWKQKVWKMPWTVGDSINMSIGQGALQTTPLQVAIMFAVPANGGYRVQPHLLKDNEEAKNWRSSLDMKPTTIKVLQEGLRKVVAEGTGKALNQPTVPPVAGKSGTAEAWKRGVKQNHAWFGAYAPADKPELLIVAFAEHSGGGGGSVAAPIILEIMEEYFQRKYPGKYQKAAKAKT

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Crispr_ID: NZ_AP018172_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_6

2591266-2591387

Orphan

Consensus_repeat	Method
GGTGACATTACTATCACTTCAGGCTCTCTCTCCCTCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018172_6

>merge|NZ_AP018172|6|2591266-2591387|CRISPRCasFinder
GGTGACATTACTATCACTTCAGGCTCTCTCTCCCTCACTAATGGAGCACGGGTGAGTACAGATATGCGTGGACAAGGAGATGGAGGTGACATTAGTATCACTTCAGGCTCTCTCTCCCTCAC

>NZ_AP018172|6|5|2591266-2591387|CRISPRCasFinder
GGTGACATTACTATCACTTCAGGCTCTCTCTCCCTCAC	TAATGGAGCACGGGTGAGTACAGATATGCGTGGACAAGGAGATGGA
GGTGACATTAGTATCACTTCAGGCTCTCTCTCCCTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096588516.1\|2580459_2583063_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|238504
NZ_AP018172.1\|WP_096588525.1\|2598686_2602373_-\|magnesium-chelatase-subunit-H	unknown	unknown	gnl\|CDD\|215643
NZ_AP018172.1\|WP_096588526.1\|2602610_2604638_-\|DUF3137-domain-containing-protein	unknown	unknown	gnl\|CDD\|378641
NZ_AP018172.1\|WP_096595217.1\|2586385_2587042_+\|DUF928-domain-containing-protein	unknown	unknown	gnl\|CDD\|368720
NZ_AP018172.1\|WP_096588523.1\|2596068_2596530_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588529.1\|2605990_2606176_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588518.1\|2584028_2585915_+\|CHASE2-domain-containing-protein	unknown	unknown	gnl\|CDD\|226703
NZ_AP018172.1\|WP_096588517.1\|2583286_2584000_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP018172.1\|WP_096588527.1\|2604647_2605190_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NZ_AP018172.1\|WP_096588524.1\|2596859_2598581_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NZ_AP018172.1\|WP_096588530.1\|2606276_2607056_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369367
NZ_AP018172.1\|WP_096588528.1\|2605638_2605872_+\|DUF4288-domain-containing-protein	unknown	unknown	gnl\|CDD\|379479
NZ_AP018172.1\|WP_096588513.1\|2575721_2576399_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP018172.1\|WP_096588514.1\|2576894_2577638_-\|rhodopsin	unknown	unknown	gnl\|CDD\|320372
NZ_AP018172.1\|WP_096588515.1\|2578584_2579913_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP018172.1\|WP_096588521.1\|2592112_2594506_+\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|225751
NZ_AP018172.1\|WP_096579665.1\|2577834_2578572_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP018172.1\|WP_096588522.1\|2595131_2595950_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349401
NZ_AP018172.1\|WP_096588512.1\|2573754_2575680_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_AP018172.1\|WP_096588519.1\|2587097_2589950_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|227328

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096588516.1\|2580459_2583063_+\|CBS-domain-containing-protein	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	7.2504e-161
NZ_AP018172.1\|WP_096588525.1\|2598686_2602373_-\|magnesium-chelatase-subunit-H	gnl\|CDD\|215643	PLN03241, PLN03241, magnesium chelatase subunit H; Provisional.	0
NZ_AP018172.1\|WP_096588526.1\|2602610_2604638_-\|DUF3137-domain-containing-protein	gnl\|CDD\|378641	pfam11335, DUF3137, Protein of unknown function (DUF3137). This bacterial family of proteins has no known function.	1.26695e-38
NZ_AP018172.1\|WP_096595217.1\|2586385_2587042_+\|DUF928-domain-containing-protein	gnl\|CDD\|368720	pfam06051, DUF928, Domain of Unknown Function (DUF928). Family of uncharacterized bacterial protein.	1.08864e-23
NZ_AP018172.1\|WP_096588518.1\|2584028_2585915_+\|CHASE2-domain-containing-protein	gnl\|CDD\|226703	COG4252, COG4252, Predicted transmembrane sensor domain [Signal transduction mechanisms].	3.71891e-109
NZ_AP018172.1\|WP_096588517.1\|2583286_2584000_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.79606e-24
NZ_AP018172.1\|WP_096588527.1\|2604647_2605190_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	7.61748e-49
NZ_AP018172.1\|WP_096588524.1\|2596859_2598581_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	6.47391e-115
NZ_AP018172.1\|WP_096588530.1\|2606276_2607056_-\|hypothetical-protein	gnl\|CDD\|369367	pfam07444, Ycf66_N, Ycf66 protein N-terminus. This family represents the N-terminus (approximately 80 residues) of Ycf66, a protein that seems to be restricted to eukaryotes that contain chloroplasts and to cyanobacteria.	1.09429e-41
NZ_AP018172.1\|WP_096588528.1\|2605638_2605872_+\|DUF4288-domain-containing-protein	gnl\|CDD\|379479	pfam14119, DUF4288, Domain of unknown function (DUF4288). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	2.16351e-07
NZ_AP018172.1\|WP_096588513.1\|2575721_2576399_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.41511e-87
NZ_AP018172.1\|WP_096588514.1\|2576894_2577638_-\|rhodopsin	gnl\|CDD\|320372	cd15244, 7tm_bacteriorhodopsin, light-driven outward proton pump bacteriorhodopsin, member of the seven-transmembrane GPCR superfamily. Bacteriorhosopsin (BR) serves as a light-driven retinal-binding outward proton pump, generating an outside positive membrane potential and thus creating an inwardly directed proton motive force (PMF) necessary for ATP synthesis. BR belongs to the microbial rhodopsin family, also known as type I rhodopsins, comprising light-driven inward chloride pump halorhodopsin (HR), light-gated cation channel channelrhodopsin (ChR), light-sensor activating transmembrane transducer protein sensory rhodopsin II (SRII), light-sensor activating soluble transducer protein Anabaena sensory rhodopsin (ASR), and other light-driven proton pumps such as blue-light absorbing and green-light absorbing proteorhodopsins, among others. They have been found in various single-celled microorganisms from all three domains of life, including halophile archaea, gamma-proteobacteria, cyanobacteria, fungi, and green algae. While microbial (type 1) and animal (type 2) rhodopsins have no sequence similarity with each other, they share a common architecture consisting of seven-transmembrane alpha-helices (TM) connected by extracellular loops and intracellular loops. Both types of rhodopsins consist of opsin and a covalently attached retinal (the aldehyde of vitamin A), a photoreactive chromophore, via a protonated Schiff base linkage to an amino group of lysine in the middle of the seventh transmembrane helix (TM7). Upon the absorption of light, microbial rhodopsins undergo light-induced photoisomerization of all-trans retinal into the 13-cis isomer, whereas the photoisomerization of 11-cis retinal to all-trans isomer occurs in the animal rhodopsins. While animal visual rhodopsins are activated by light to catalyze GDP/GTP exchange in the alpha subunit of the retinal G protein transducin (Gt), microbial rhodopsins do not activate G proteins, but instead can function as light-dependent ion pumps, cation channels, and sensors.	7.09686e-66
NZ_AP018172.1\|WP_096588515.1\|2578584_2579913_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.98864e-51
NZ_AP018172.1\|WP_096588521.1\|2592112_2594506_+\|S-layer-family-protein	gnl\|CDD\|225751	COG3210, FhaB, Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion].	0.00174088
NZ_AP018172.1\|WP_096579665.1\|2577834_2578572_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.32422e-81
NZ_AP018172.1\|WP_096588522.1\|2595131_2595950_+\|hypothetical-protein	gnl\|CDD\|349401	cd05382, CAP_GAPR1-like, CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins. Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.	5.3735e-39
NZ_AP018172.1\|WP_096588512.1\|2573754_2575680_+\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	0
NZ_AP018172.1\|WP_096588519.1\|2587097_2589950_-\|CHAT-domain-containing-protein	gnl\|CDD\|227328	COG4995, COG4995, Uncharacterized protein conserved in bacteria [Function unknown].	2.05992e-99

>NZ_AP018172.1|WP_096588519.1|2587097_2589950_-|CHAT-domain-containing-protein
MNKNNCCDRIFNIQIKNKYCKLLLSAPQQTHILLKLGNLCQRIIYCFTQQYQKLNFHRFTKLFFLLTLIICLLFGQVVSAQSPNTNVVIKQGIKEYNSGNFFNAIQNWQEALNQYKNNPSATAVVNENLARAYQQIGENKDAIASLEAAIRDYGVVENIQQVGRMKSELAQVYSDLGQPRKAIALLCGQLVDKSKYPVNQNIECTSDSAAQIAIKYNDKRGQVAALGILGEAYRLVGSYDQAIKYLDAAQQVTPEYQFLVFNSLGNAYKSRGQLRELQADSAKKAGISSKEQELTQKSLDDYKRAYQYFQDSIKFARNQKQAVAEMRGLLNLIQLASQTNKNKFINDEEFNKTLQDALKVLESLPDSATKVYGEIDLAYLQRNNKGTSLFTDCPTHLILSSENEALNLLENSILTSKKIQDNRLISYSNGALGHFWECRRDNNKALKYTQAAIIAADSKLSAKDSLYLWEWQAGRILDAQNQKQEAIASYQRAFDTLEDIRQDILTAERDVQFDFRDVVRPLYRTLAQSRLELLGVGAITDEGRAKELSKVVNTIDALKLAELQNYFGNDCILSGLNPKLVGELLEENSVAFKNSAFLSSIILNNKTGILLQLPDRATKFKWIEDPNQQGTTKIVSSDTLEKKIAEFRKGLISKEEINYDTTIAAQLYDWIIRPFADDIKSQKIKTLVFIQDGFLRSVPMAALYDSQQKKYLVETYAVATTPSLRLTKPTLRDRSIQKALILGLTQKATIDSKTFNPLFAVPNEVSAVESIFPNCTPLIDDNFTSKNFQQQLEKTPYSIIHIASHAQFGIIPEDTFIVTGKNQKLTISQLETSLRNLKTKSDNIELLTLTACETAVGDDRATLGLAGVALQVGVKSAIASLWSVTDESTSELVKTFYTKYRNTSVSIAQALQTAQIRMINAKKLPSSENLNPLYDHPAYWAPMIAIGNWL
>NZ_AP018172.1|WP_096595217.1|2586385_2587042_+|DUF928-domain-containing-protein
MTAFPVSAQFQPRDRKPASGNSRAGGSRGCSSNGISMTQLAPVTFIGKTASTRPILVWYMSSSQNVRFRLFELDGAKSVKQIGKFQEIPTIVGINQLKLPLNYPELTVGKTYLWQIAIDCNNDTIINHAEFTVINPQSLPQKRFATIPDSVNYYAQNELWYEALGEALKATDTGKLGQIGATLINELAQSEIPTGSDIDIKKIQQRIDDLQKIASEKI
>NZ_AP018172.1|WP_096588518.1|2584028_2585915_+|CHASE2-domain-containing-protein
MQRRIWNLIRQELGLWSQAAPPGIMVLVVVILIRIAGGMQSLEWIFLDTMLCLRPVEKLDERVVIVGIDEKDIQSVGQYPVPDEKIAQLLTKLETYQPLAIGLDIFKNVPVEPGGEQLTQVLQKNQNIIGIEKILPPGEIAPPRSLLPQKVGFVDLPNDEDSKNRRYLLYTPNPQNVNEDKYSLALRLINNYLQNQAINISTGKNDPNTIMFDRVELPRITKNFGGYVNVDDGGLSILMNFRNNSQPFYVVSLLDIINDKVDGKLLRDRIVLVGNRNMSVGDFFYTSALPSLKLSGQIYGIDYHAHVISQVLSTVIDGRPMLYSWGDMGEYAWIFICGLLPIAIGRLTQSVWKNLLSVAVAGFCLFSCGYVMLWLWGIWIPVAPNLLILAVNGLGLSAFAFYRHDRFLRSQIKERQNTIQHTFTIIHNGPLQTLAYGLQHLRAQDIPYEQLVEQFEKLDREIREIGDFLKLEALTKEESLRLGSGLILELKRPLHDLLYEVYSTTLERPNFENFKTLKVKVRNFEPIDEKYLSWEDKREICLFLEEALCNVGKHAKGVKRVQASGIYSENQYKLSVKDNGLGIKSKLENKGTKNSKTLAKQLGGEFRRESLFPRGTICELSWTPMKKF
>NZ_AP018172.1|WP_096588517.1|2583286_2584000_+|response-regulator-transcription-factor
MTVLSLETYQIYGHLPVDKKLNILIVDDHELILTGTFDVLSRNYPEANIQKVQTAQQLLTLLPCPHQFDLIVMDLSIPNQQGETAEIDTGIKLLQTLLKEYPVCNFVVQTSYVKALIRIKHEIDNHQAGFAIADKGLPEAEMLIRVNLALQGGTHTKDIKTGIELKPEWLEVLRLAFEESLTDKAIAERMYKSERAIRAYWTKIQDVLGVYPEDCKQSGKNMRIQTEIRSREEGLID
>NZ_AP018172.1|WP_096588516.1|2580459_2583063_+|CBS-domain-containing-protein
MFVRGKILWLRLYRQMLQPRRLAFFEACAIGLVSGLAAVVLGQAVDWAGAWRVHISYLWPAYLVLPAIGLVGGVLAGWLVERFAPEASGSGMSEVKAVLARVPMPLNLRIALVKLVSATLVLGSGMPLGREGPTVQIGAALANQLSNWVPTSPEHRRQLIAAGAGAGLAAAFNAPIAGVLFVVEELLQDVSGITLGTAILASFIASVISRLYGSHSLDLNVNLAVTHTTFFAQEIPFYLILGVLAGLLGILFNKSVIASLAVNRRLLRLSLPWRIGIVGLITGIVIALLPVAFRNHAGLRDMLLTGSSDSLLAAIAFIVQFSLIILTYGSGAPGGLLVPTLVLGAALGYLVGAMQESLLAMSAATTYAHVGMAAFFSAVSKVPITAVVIVFEMTTDFNLVLPLMIVSVVAYLVAEKIDYRSLYDLLLEWKGIHIKKEPVAEGLLAQLTAADVMQRRVETLSSKMSIDEAVQAFSHSHHRNFPVVENGKLVGLVTQKDVVNTNSQQLARDTPIDRIMTPEPVTVSPTATLAYVLHLLNRYNLSCLPVTEGRKLVGIITRTDIIRVEAERLNGNVDKMEPTKTLEPSYVIYQTRAPAIRKGRLLVPLSHPQTAETLLEMAAAIAKQKNYEIECLQVIIVPRDRTPSETPVNTHKSHRLLQQAVQLGEDWRIPVHTQIRVAHDVAGAILETVKERHIDLVLMGWKGNTSTPGRVFSRVVDTVIRQAACDVVLVKLNDHKGFERWLLPMAGGPNSSQAIQLLPALTSLSSSPAIKLYQVFKPTESQPDTTLLDNCVRFLQPRVNGQITATPVCASSVPEAVIDCAQQDHSDVIILGASRESLLKQAINGNIPENISRRSNCTVILVRSATA
>NZ_AP018172.1|WP_096588515.1|2578584_2579913_+|HAMP-domain-containing-histidine-kinase
MEHNPIFHQTRLRLAAWYTIVMGSILGLSGLGVYSVVAHAYQETIDRGLESVAKAIHKSIEPAWQQPRHLEELAKEVSLKLCLTPTNCLPKTTIIKQPIAEEANQVNYYIRLLDRSEKLFAIAGMSFNNLPMAAPVKQWQILTDSSGARYRQITLPLYTQNQLSGYLQVVRSLSDLDQHLNYLRFTLILGLPISMIFVGLSSWWLAGRAMQPVYHSYQQMQQFTADAAHEFRTPLAAMYSTIEAAIKLQQEPKSNSGILDVLKRQNRRLSQLVGDLLLLTRIDQKQLTGEYKSCCLNDLISDLIEELAFLAVEAQVNLSQQVIVGKKIYVMGNEEQLYRLFSNLIMNAIQATPSGGKVTVFLEASEHYAIIKIQDTGIGIAVEHQARIFDRFYRVDRDRSRTSGGSGLGLAIAIAIAIAHKGSIHLQSQPGLGSKFTVRLPL
>NZ_AP018172.1|WP_096579665.1|2577834_2578572_+|response-regulator-transcription-factor
MRLILVEDEADLGAAIKEVLSHEAYVVDWFLDGTQAWQYLETGWTEYTLGIFDWMLPGISGIELCRWLRSRQLILPVLMLTAKDRMEEKIIGLDSGADDYLVKPFDMAELLARLRALQRRASYVGTTFTPQIQPRRLQVGCLTLNYITHELTRHYPNGEKQLLSLTAKEFQLLEYFMRHPHQIISRDQIINQLWEIGAEPCSNVVAAQIRLLRRKLGEEDSESLIETIYGVGYRLNIHTEKQAAL
>NZ_AP018172.1|WP_096588514.1|2576894_2577638_-|rhodopsin
MTQFWLWVGFIGMVIGCIYFGMKASAMRRREGMEFPLESFFITLWAAALYLTMILGETVTPINGQTVFWGRYIDWVVTTPLLLMELGVIAGLRPKLIAGVMGADIFMIVTGFIGAVEAPPYNYLWWLISTGSFLAILGSLLTEYSASAKRRNGRINSLFQTLRNILIVLWICYPIVWILGAEGFHVISVGWETLCYSVLDVCAKVGFGFVVVSAGNETLAQASNSDRIMETVHSYMQSEEREQSPYR
>NZ_AP018172.1|WP_096588513.1|2575721_2576399_+|response-regulator-transcription-factor
MRILVVEDDVQLAEMLVEALTDRQYVVDVAQDGEEAWDFIKGLEYDLVVLDITLPKLDGVSFCQRLRSHHHSLPVLMLTARDTLADKVTGLDAGADDYMVKPFEMPELMARIRALLRRNQSATSFSGLSWGDLHLNSSTYEVTYAEQPLHLTPKEFALLELMVSSGRRVLSRTGIIERIWSLNDPPSEETVKSHIKSLRNKLREIGAPDDFIETVHGLGYRLKQI
>NZ_AP018172.1|WP_096588512.1|2573754_2575680_+|penicillin-binding-protein
MSSSKILDKNPSQIQTLPSVEFWKEVGQVTGGTLLSIMLLSTAAISGGLVGLAISFRDLPDVRQLRNFFPTETTYIYDIQGKLLARIHGEANRQVVPLDAISPNLKRAVLASEDSNFFEHHGINPVGIGRAAITNFVAGGVREGGSTITMQLVKNLFLSQKRAVTRKIAEAVLAIRLEQVINKDQILEMYLNQVYWGHNNYGVQTAARTYFNKSAANLTLAESAMMAGLIPAPEEYSPFVNMKLAKQKQKEVLGRMLELNWISQQEYNDALNQKIKLGKIKSFQGSALPYVTNTVAQEIIKKFGREALLKAGMRVQTTVDTNFQLMAEDTIKKWHRTLESEGIYKNQMALVAIDPRTHFVKALVGGIDAKTSEFNRATQAQRQPGSSFKPFVYYTAFASGKFTPNSTILDTPVSYRDGSGWYYPRNYDNSFMGAISIRTAVALSRNIPAIKIGKAVGMDKVIETCRTLGIMSPMVPVSSLPLGAIGVTPLEMASAYATFANYGWQSPATIIARVTDSSGNVLLDNTPKPQLVLDPWASAATLDVMQSVVNEGTGRGAAIGRPVAGKTGTTSSEKDIWFIGTVPQLTTAIWVGRDDNRQLAHSATGGGTVAPVWRDFMQKALKDVPVERFQPPSKFPRPKSN
>NZ_AP018172.1|WP_096588521.1|2592112_2594506_+|S-layer-family-protein
MSTDMRGQGDGGDLFIKATELVEVLGTEEPGTYSSMGADVSFGGIGNPGNLTIETKKLVIISSQVGTATNGKGNAGNVTVKASESVEIYGKISSTNSDPTKPLIINPAGLFAQVNTQGEGNGGNLKVETPSLSIGDGGKIQVAVFGKGDAGNLKIRAADIDIYDTPGKADFFQGGIFAGFQVDNDESTKPPQGDFGGIITIETDRLRVRNGGAVTVLTEGEGNAGRLQINAKDYIEVYGKVTTATTNSIFTSKISGEATKDSTGNGGTVILNTDKLIVRDSGNISASTSSIGKAGDILLNTNTLTVASGGEILAFTEGSGNGGTITVNAAKEINLGIGVQDFVPVLSVETSGAGKAGDIFVTTPILTLSDTARITATATATATNSSGGGSISLNASKMNLAGIVGVFAETQGESPAGTLRLQSDNNKSTLDLTLAPGSKISASTSGSANGGDLLVSAPQAINISGQGKLAVETTDTGNAGNIEISTQKLTLSDGVQISASTSSSGKAGNINLNVGENITITGSGTGLFASTSENSTGKGGSIIIDPRIMKIRDGATISTNSQGEGIGGDIKLTAGSLTLDNGKISAETRSSKGGNITLNVQDLLLLRNGSQISTTAGTAFAGGDGGNINFDGKFIVAIPNENSDISADAFAGNGGNIQINAQGIFGIESRAKPTDKSDITASSEQGISGAINLNQPDNSSLQNSFSQLSPNVIDTNALIANSCIARGSKKQENSFTITGSGALRNSPGDVLISTYSTGDVRNVEPTSQTWKKGDPIIEPQGLYRLSDGQLLLSRTCS
>NZ_AP018172.1|WP_096588522.1|2595131_2595950_+|hypothetical-protein
MTTLFPGQSLYPGQSLQSNNSLHTFIMQSDGNVVLYDRNSQPLWATNTWGIQPRELIMQTDGNLVLYDTSGSPRWASNTWNNPGAFFNIQDDGNLVVYRAGSQTETADNALWASGSNDIWESGGQGGQGGQNAQIQEMLAAHNRYRAEVGIPPLQWSDNLAASAQQWANHLAGTGTFEHSHNGSGENLAQGSTGFFSVTKLVDMWGDEKQYFSNGTFPNVSSTGNWMDVGHYTQVIWRNTTEVGCGLASGNGNDVLVCHYNPGGNVTGQGVF
>NZ_AP018172.1|WP_096588523.1|2596068_2596530_+|hypothetical-protein
MLLFFTMPLDETSQLNRGRLFLVDDTKGIVGRWVATSSTADKQGVKDWNIRGGVIPATHELNPPLPFYSVAVKPVDLRNVKGVEGNAYPISPFEVKTIDGGTRSDLLIHKDANVPGSMGCIVLPESEFTDFEKAFQKYCAGEDSVKLLVGYTY
>NZ_AP018172.1|WP_096588524.1|2596859_2598581_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MGFYLRIQTLSLILLAFISITSMATFAQSRPPSGVTIPPDTPGKVEETLPQASPKPPPTTSPPTVPILPSSPQENLPDTIFPSGESFFVKEIQVKGYSVLKDEIFKLKQPLENKKITFEQLLQLRSQITELYVRKGYITSGAFIPNNQNVANGVVQIQVVEGELEDIYIEGLQRLQSAYVRSRIQRFAGTPLNKNSLEEALQLLQIDPVIERVNAELIAGSTSGSNILRVKITESPAFHAGVIFANDQSPSVGSEQGSVFVAHDNLLGLGDEFSAEYGITEGLDMYNLSYSVPFNALDGTIGVRYSNSSSRIIESEFRELNIKSEAETLSFNVRQPLIYTPNKEFALSLAFDLRRSQTFILNDIPFSFTEGPEDGKSRVTVIRFSQDWLQRNANTVLAARSQFSFGIDAIDATINDSGTDGRFFSWVGQFQWVQRLSPRILMLAKINTQLTPDSLLTLEKISIGGVETVRGYRQNQLVADNGVVGGVEVRIPLTSNVETLQLLPFFDIGTVWNNRDRNPDTQTLASLGLGLQWQPISGLVLRADYGLPLIGTSDRGSSLQDNGFNFSVRYQPF
>NZ_AP018172.1|WP_096588525.1|2598686_2602373_-|magnesium-chelatase-subunit-H
MKRIVLIAGFESFNADLYRKAAFVANSRCPELDICVFSDRDITTKRQEVEAALQDADVFFGSLLFDYDQILWLRDRISQIPIRLAFESALELMSLTKLGDFAIGDKPKGMPKPVKFILDKFSNGREEDKLAGYISFLKVGPKLLKYIPVQKVQDLRNWLIIYGYWNAGGPENVASLFWTLAEKYLGLKVGDIPAPVETPNMGLLHPNYQGYFESPKAYLEWYQQKFNLQNPVVGILLYRKHVITKQQYIPQLIRRFEAAELIPLPIFINGVEGHVAVRDWMTTDYELQQRQVGNIETPSLSQEAVKVDAVVSTIGFPLVGGPAGSMEAGRQVEVAKRILTAKNVPYFVAAPLLIQDIYSWTRQGIGGLQSVVLYALPELDGAIDTVPLGGLVGEDIYLVPERVQRLIGRVKSWINLRQKPASERKIAIILYGFPPGYGAVGTAALLNVPRSLLKLLQALKEQGYNVGDLPEDGEELIRWVKEADEEIKTADERGLTQMDIGVHRRSSAVNTVNVRELEKWLGYLRTSRIEKQWKSLTGTGIKTYGDEFQIGGVQLGNIWIGVQPPLGLQGDPMRLMFERDLTPHPQYAAFYKWVQNELAADAVVHFGMHGTVEWLPGSPLGNTGYSWSDILLGDLPNLYIYAANNPSESILAKRRGYGVLISHNVPPYGRAGLYKELLALRDLISEYREDPQKNYALKEAICRKIVDTGLDADCPLADAKKLGIPFSYENVRMFSAHVFDDYLVKLYEYLQVLESRLFSSGLHTLGEEPNEEKMAGYLEAYFGDEPRRREGREGEEIRDLLMQSTEELTNLLRGLNGEYILPAPGGDLLRDGPGVLPTGRNIHALDPYRMPSPAAYERGREIAQKIIAQHLQEHRKYPETVAVMLWGLDAIKTKGESLGILLELVGAEPVKEGTGRIVRYELKPLAEVGHPRIDVLGNLSGIFRDSFVNIIELLDDLFQRAADAEEPEEENFIRKHALALKAQGVENTSARLFSNPAGDFGSLVNDQVVDGNWESGDELGNTWQSRNVFSYGRQDKGQARPEVLNTLLKTSDRIVQEIDSVEYGITDIQEYYANTGGLKKAAEKQRGKKITTSFVESFSKDTTPRNLDDLLRMEYRTKLVNPKWAQAMANQGSGGAFEISQRMTALIGWGGTADFTDDWVYDQAADTYALDAEMAEKLRKANPEAFRNIVGRMLEAHGRGFWQADKDKLDKLRQLYDLTDEELEGVTV
>NZ_AP018172.1|WP_096588526.1|2602610_2604638_-|DUF3137-domain-containing-protein
MPKLTNEKIKEILSAIINLLNYQNYNLALKLLENLLQNVEPNTKEYLYAQVLLLDAYHCTGMSQQAMNLCQELSNSEYHITRVLAQYYLGQISPETNLTEEESSVNLSKDLLTTAQAAELITAGYQALTQKQYTEAIAKLEKFCQGADPNTKQYLQAHKWLVKAYQENGQIDRAIALCQPLLIHQYEAIRKWARHLLYTKLFIHNFTPPVLTLNTEEAIFPAKLEVSDLPEASEIDTFTPKTLKEFKTFCQTTLVDELKTLESLRKQVLYSVIVSQIIALFLGFALIKAFPIILTDLKFTPDSHLGFWFFNIGSLHIVIPFLFIIVLAHYLLIFLFIFWLWILFYNSAFETFSHGLKSKINEKIFTFFNENKNLKYINTLSSENISKSFNYFQHSQLFQGLLKPNKIIQDDYIEGEVNGVNIWFSNIHAELQLKHYWTHPLDITFFMSNNDATIIDVNSFRNFLFSILRILYFFTFLLPFTFYIGFLLFRFFKLSPYLFNNILQGKNIDYKKFESEILRNEVTRTNVVFKGIFFKAKFNKNVKTATIVQPKSISLNIHALNHGTKQLIKLEDPEFARLFTVYADDQVEARYVLSTSLMEKIIKFRQKTNRNIYLSFVDDMIYIAIEQLVDNEIFEPNLYKSTLRFAPLQEYFENMNLVLGIVEDLNLHTRIWHPR
>NZ_AP018172.1|WP_096588527.1|2604647_2605190_-|LemA-family-protein
MFVYLISALFLLLIIFISLYNKLIYKKNQVDNAFATIDVLLQKRCDLIPSLVAVAQIYVQFEQRVLTEISRLRTIANSQKLSGNSRVIVEEQITQVLNKILIAVEAYPELKANQHFLQLQYSLNEVEEQISAARRFYNTAVTEYNTAVEMFPTNLIAWGMKYKLKVHFQATLETKSNFKI
>NZ_AP018172.1|WP_096588528.1|2605638_2605872_+|DUF4288-domain-containing-protein
MGVVAAVVALGSSEEAKVKAVDYGKNESVSYTNENGETITWSLQQVIDVNSVLYDDIDSSEDVVDLYTRHFRNYDAY
>NZ_AP018172.1|WP_096588529.1|2605990_2606176_-|hypothetical-protein
MTNPDYQAMSDDELRDWVRYHPQDTEAFHILMDRLDQWPKVIARTDEEFEIELQRRISQAS
>NZ_AP018172.1|WP_096588530.1|2606276_2607056_-|hypothetical-protein
MLAYVLALAVGLGSLAIYLAAFFFPEIHRKNDFIWSGVGLFYALMLWVFAQRINGGLLLGHVASVALLGWFGWQTFSLRRQVTPKAQQTPVPSSDAVKTSIQQQVTKLSLPERLAQLQQGIGNTFSGVKGKFQKTPKQAPATSKTKASSLVEIIDNTAATTETAVEEAVTIADTESPTVISEQPTDEVVTTTDTEATTESIPEVIPPNPPSPELVEAAQAHSETENKEPIPVEEIAPDAVLAPPAEAPPEQIPPNNQPS

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Crispr_ID: NZ_AP018172_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_7

2730193-2730466

Orphan

Consensus_repeat	Method
TGTTTCAGTCCCCTTGCGGGGAAAT	CRISPRCasFinder
TGTTTCAGTCCCCTTGCGGGGAAATTAGTTATGGAAAC	CRT

3 spacers

The CRISPR arrays of NZ_AP018172_7

>merge|NZ_AP018172|7|2730193-2730466|CRISPRCasFinder,CRT
TGTTGCAGTCCCCTTGCAGGGAAATTAGTTATGGAAACACCTGGAGGAAACAGCCACTACACAACTGTGGGGCGGCTTGTGCCAATGTTTCAGTCCCCTTGCGGGGAAATGGTTGATGGAAACCCAAAAGGCCCTGCAATAATATAAAGTTCTTTGCCTTGACTGTTTCAGTCCCCTTACGGGGAAATTAGTTATGGAAACTTCGGCAATTATGCCCCGCACCGAGGCATATGAAATGTTTCAGTCCCCTTGCGAGGAAATTAGTTGTGGAAAT

>NZ_AP018172|7|6|2730193-2730453|CRISPRCasFinder
TGTTGCAGTCCCCTTGCAGGGAAAT	TAGTTATGGAAACACCTGGAGGAAACAGCCACTACACAACTGTGGGGCGGCTTGTGCCAA
TGTTTCAGTCCCCTTGCGGGGAAAT	GGTTGATGGAAACCCAAAAGGCCCTGCAATAATATAAAGTTCTTTGCCTTGAC
TGTTTCAGTCCCCTTACGGGGAAAT	TAGTTATGGAAACTTCGGCAATTATGCCCCGCACCGAGGCATATGAAA
TGTTTCAGTCCCCTTGCGAGGAAAT

>NZ_AP018172|7|4|2730193-2730466|CRT
TGTTGCAGTCCCCTTGCAGGGAAATTAGTTATGGAAAC	ACCTGGAGGAAACAGCCACTACACAACTGTGGGGCGGCTTGTGCCAA
TGTTTCAGTCCCCTTGCGGGGAAATGGTTGATGGAAAC	CCAAAAGGCCCTGCAATAATATAAAGTTCTTTGCCTTGAC
TGTTTCAGTCCCCTTACGGGGAAATTAGTTATGGAAAC	TTCGGCAATTATGCCCCGCACCGAGGCATATGAAA
TGTTTCAGTCCCCTTGCGAGGAAATTAGTTGTGGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096588631.1\|2749610_2749832_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588633.1\|2751327_2757327_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NZ_AP018172.1\|WP_096588616.1\|2720252_2721764_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NZ_AP018172.1\|WP_096588615.1\|2719124_2720105_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NZ_AP018172.1\|WP_096588618.1\|2722789_2724424_+\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|235391
NZ_AP018172.1\|WP_096588627.1\|2735917_2736373_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588622.1\|2728680_2729541_-\|cyanoexosortase-A	unknown	unknown	gnl\|CDD\|163475
NZ_AP018172.1\|WP_096588617.1\|2721938_2722655_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_AP018172.1\|WP_096588623.1\|2729539_2729749_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588621.1\|2726637_2728350_-\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_AP018172.1\|WP_096588629.1\|2737136_2737988_+\|S-formylglutathione-hydrolase	unknown	unknown	gnl\|CDD\|131868
NZ_AP018172.1\|WP_096588625.1\|2733015_2734326_+\|proton-extrusion-protein-PcxA	unknown	unknown	gnl\|CDD\|235046
NZ_AP018172.1\|WP_096588614.1\|2714156_2718977_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NZ_AP018172.1\|WP_096588619.1\|2724481_2725702_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|379138
NZ_AP018172.1\|WP_096588624.1\|2730750_2732928_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588626.1\|2734377_2735685_+\|murein-transglycosylase-A	unknown	unknown	gnl\|CDD\|225377
NZ_AP018172.1\|WP_096588632.1\|2750377_2751022_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|133025
NZ_AP018172.1\|WP_096588620.1\|2726168_2726507_+\|XisI-protein	unknown	unknown	gnl\|CDD\|341357
NZ_AP018172.1\|WP_096588628.1\|2736470_2737058_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|372434
NZ_AP018172.1\|WP_096588630.1\|2738159_2748440_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096588633.1\|2751327_2757327_+\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	0
NZ_AP018172.1\|WP_096588616.1\|2720252_2721764_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NZ_AP018172.1\|WP_096588615.1\|2719124_2720105_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	0
NZ_AP018172.1\|WP_096588618.1\|2722789_2724424_+\|hydroxylamine-reductase	gnl\|CDD\|235391	PRK05290, PRK05290, hybrid cluster protein; Provisional.	0
NZ_AP018172.1\|WP_096588622.1\|2728680_2729541_-\|cyanoexosortase-A	gnl\|CDD\|163475	TIGR03763, conserved_hypothetical_protein, cyanoexosortase A. The predicted protein-sorting transpeptidase that we call exosortase (see TIGR02602) has distinct subclasses that associated with different types of exopolysaccharide production loci and/or different taxonomic lineages. We designate this relatively divergent cyanobacterial type to be type 3. We propose the gene symbol xrtC. This type coexists with a TIGR02602-recognized form in Nostoc sp. PCC 7120. [Protein fate, Protein and peptide secretion and trafficking].	1.96156e-77
NZ_AP018172.1\|WP_096588617.1\|2721938_2722655_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.57548e-51
NZ_AP018172.1\|WP_096588632.1\|2750377_2751022_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.25415e-72
NZ_AP018172.1\|WP_096588621.1\|2726637_2728350_-\|HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	5.94656e-34
NZ_AP018172.1\|WP_096588625.1\|2733015_2734326_+\|proton-extrusion-protein-PcxA	gnl\|CDD\|235046	PRK02507, PRK02507, proton extrusion protein PcxA; Provisional.	0
NZ_AP018172.1\|WP_096588614.1\|2714156_2718977_-\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.40462e-54
NZ_AP018172.1\|WP_096588619.1\|2724481_2725702_-\|serine-hydrolase	gnl\|CDD\|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.9244e-16
NZ_AP018172.1\|WP_096588629.1\|2737136_2737988_+\|S-formylglutathione-hydrolase	gnl\|CDD\|131868	TIGR02821, S-formylglutathione_hydrolase, S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. [Cellular processes, Detoxification].	1.16987e-178
NZ_AP018172.1\|WP_096588626.1\|2734377_2735685_+\|murein-transglycosylase-A	gnl\|CDD\|225377	COG2821, MltA, Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane].	1.24108e-124
NZ_AP018172.1\|WP_096588620.1\|2726168_2726507_+\|XisI-protein	gnl\|CDD\|341357	cd16382, XisI-like, XisI is FdxN element excision controlling factor protein. This family contains XisI proteins, also known as FdxN element excision controlling factors, and similar proteins. FdxN element is excised from the chromosome during heterocyst differentiation in cyanobacteria. This is accomplished by the large serine recombinase XisF (fdxN element site-specific recombinase). The xisH as well as the xisF and xisI genes are required. XisI may function as recombination directionality factor (RDF), and needs XisH which may function as an endonuclease.	3.21464e-53
NZ_AP018172.1\|WP_096588628.1\|2736470_2737058_+\|HD-domain-containing-protein	gnl\|CDD\|372434	pfam13023, HD_3, HD domain. HD domains are metal dependent phosphohydrolases.	1.58951e-70
NZ_AP018172.1\|WP_096588630.1\|2738159_2748440_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0

>NZ_AP018172.1|WP_096588623.1|2729539_2729749_+|hypothetical-protein
MATVGLLIAKIRFLVSFGILVKLAPGYFLNKMTFINVESLNILDDTFKLAHQASYCIEKMQILTYKISF
>NZ_AP018172.1|WP_096588622.1|2728680_2729541_-|cyanoexosortase-A
MKITDLVSPKLFKTEPFWLLSIAAGLEAICLTLVWKAPDIGHLGMSILFLFATGSILWDKRHTLRFESDVFSSIVGLLLIIWVLWQSTTQNLEHTLRLLSFTSALGVGLLASGFKGLKQYWEELTILFFLGIPSVLADLFLDISPLSAKFASLLLWYLGFEVTNIGVNIYLPTGSIKVVHNCSGIDTINYILGISVIALVMFPIAKSKRFFVAIFAILLGFVINGGRIAMLAIMEGTNKAAFDSWHGGQASYSYGVLGILIFGIVYMFLLKQEEKQVENIENSSNS
>NZ_AP018172.1|WP_096588621.1|2726637_2728350_-|HAD-IIB-family-hydrolase
MRYFVLATDYDGTLATDGHVNEKTLEALERLRASGRKLILVTGRQLDDLQQVFERIDLFDYVVAENGALLYSPASRQEKLLGSQPPQEFIQALRDRHVNPLAVGRVIVATWHPHETTVLQTIRDLGLELQVIFNKGAVMVLPSGINKAAGLLAALNEMKLSPHNVVGVGDAENDHAFLKLSELSVAVANALPMLKEQVDFVTQGKRGDGVVELIDKIIANDVSDLNEQLQRHKILLGNQTDGAEVYIKPYGSSILLAGTSGGGKSTLATAVLERIAEHNYQICIIDPEGDYDNFEPGIILGNTEGAPRIAEVLDLLEQPNQNVVVNLLGIALQDRPAFFAELLSALLELRSRTGRPHWIVVDEAHHLIPASWHPASLTLPQQLKGMMLITVHPDRVATAGLSLIDTILTVGNSPEENIKAFCETLGDFPPQLQPQTLETGEALAWFREQNSEPFRFQITPGRTERRRHVRKYAEGELGEDKSFYFRGPEAKLNLRAQNLILFTQIAEGVDDETWLFHLQRGDYSRWFKEAIKDESLAEEIAEIEKSDGKSANETRDAIKAAIDKRYTLPA
>NZ_AP018172.1|WP_096588620.1|2726168_2726507_+|XisI-protein
MAVEQYRQYIKYLLSERQKRASRSRNYEEYEVQTIFDEQQDHYQLLYVGWRGNKRDFGCILHLDIKDEKIWIQHDGTEEGIANRLVEMGVPKQYIILAFHEPYVRQFTEFGS
>NZ_AP018172.1|WP_096588619.1|2724481_2725702_-|serine-hydrolase
MLLANLLLTANLVLPNKFFIEPKQQKFLQVAQVQLPKKSNMSKAALERLLTTEPVQADWFTSEFLAHVPISQIQQIISSLKQGLGDYQKVQEQGKNYIVVFARGYVPTQIAVDANGKITMLFFRPPVAQGKTLEEAIAEFKTLPGKVSFLVLEGKSERAALNANTPLAVGSAFKLAVLQILKSQITTGKRSWRDVVELQPIWKSLPSGTLQTWPAGSLLTLQTLSALMISQSDNTATDSLINIIGRQALESISPRNIPFLTTREFFILKSAKNQELLQRYRNSNLEEKRAILQSLTQQPLPDPSEFGGKPVALDIEWFFTAQELCSVMEQVADLPLMSINPGVANAEDWERVAFKGGSESGVLNLTTWLKAKNGKQYCVAATWNHDAPLEESRFFNLYASAIAGLK
>NZ_AP018172.1|WP_096588618.1|2722789_2724424_+|hydroxylamine-reductase
MFCNQCEQTTRGDVCYQWGACGKSPEVDALQDLLVHCLRGLSQVALQAKSLGITSRDSDEFTCEMLFSTLTNVNFAADDFVTFINRAIALRDSLKLKIQATGNAVVDSAIANFQPAGNFQQQIQQGKDLEFEFISQSAKNVDIFSLKLTVLYGIKGLAAYAFHALELGQHDEGLYRFVHEVLAHLDDQDKSLQYWLDLALQVGQMNLKAMELLDAGNTETFGHPTPTFVPLGHTVGKAILVSGHDLLALKAILEQTVGTDIKVYTHGELLPAHGYPKLKQIYPHLYGHYGTAWQNQTHEFERFPGAIAMTTNCLMPPHESYKDKVFTLGPVGYPGLQNVNIGDVSPIIQKALALPGFVDEKDGGTVTTGFARNAVLSVADTVIEGVKQGQIRHFFLVGGCDGAKPGRNYYSELVEQIPDDCIVLTLGCGKFRFFDKNLGNIGGIPRLLDVGQCNDAYSAIKIAVALADAFGVGVNQLPLSLVLSWYEQKAISVLLTLLHLGIQNIRIGPTLPAFLTPNVVKLLSETYNLKLITTPEQDLAACLG
>NZ_AP018172.1|WP_096588617.1|2721938_2722655_-|Crp/Fnr-family-transcriptional-regulator
MLVSERILEVKQFLQKTPIFQGVLDEQLQALANIAIPQTYQKGETLFWEGDESTGFFIVKSGRIKVFKLANAGKEQILHIFGAEEYFAEVPTFDGGKFPASAAALENSEVVFIPRAAFLMVLQQHPSLALAMLSTFARHLRRLTHLVDTLSFQEVPERLTNYLLMLSDRNGNTDVVELDLPKGQLAALLGTIPETLSRAFYKLSQEGIIEMNGTKIRLCRHRRGRGEEGGEQGSKAFP
>NZ_AP018172.1|WP_096588616.1|2720252_2721764_-|aldehyde-dehydrogenase-family-protein
MTATTPSRTNNSTANAPAPYTGFDRLFIDGRWVAGRSEHKLRPIDPYRQQVILEIPAADRRDLEDAYQAAQHAQKAWAQTLPSERSLIMRRAAEIMDTRREEIISWSIKEAGSPRKKAMLEWKAARDVMEQAVSAPYGAEGRILPSDIPGKESRVYRRPVGVVGVVSPWDFALNLANRSVAPALALGNAVVLKPPSNTPISGGLIFGKIFEEAGLPAGVLNIVAGPAREIGDAFVSHPIPRVITFTGSTKAGRHIGELAMTSPIMKRVSLELGGNSPLVVLDDADLELAVNAAVFGKFLNEGQICMSINRIIVDELVHDEFVDRFVDRVRNLKLGDPNDPDTEIGPIVDEAQLNSLLKHIQQARQEGARQLLGGDPQGLMLPPHVFVDVNNQMSVAREEMFGPLASIIKVRDEAEALQVANDTEYGLSSAVFTRDEGRGLRFALGMEAGMTHINDQTVNDLPNAPFGGEKNSGIGRFGGNWAIEEFTTDHWITVQHTPRKYPF
>NZ_AP018172.1|WP_096588615.1|2719124_2720105_-|aldo/keto-reductase
MKTRKLGKQGLEVSELGLGCMGMSEFYSGRDEQEAIATIHRALELGLNFLDTADMYGPFTNEQLVGRAIKDRRDRVVLATKFGNVRTEDGGWKGISGKPEYVRQACDASLKRLGVDVIDLYYQHRVDPTVPIEDTVGAMAELVQQGKVRYLGMSEAAPATIRRANAVHPITALQTEYSLWSRDPEDEILPTVRELGIGFVPYSPLGRGFLSGAIASLDDLAPDDYRRNSPRFQGENFSKNLQLVEKVKAMANDKGVTPTQLALAWLLAQGEDIVPIPGTKRRTYLEENIAATEITLTPEDLKQLEAIAPKGVVAGDRYPDMSTVNR
>NZ_AP018172.1|WP_096588614.1|2714156_2718977_-|PAS-domain-S-box-protein
MKRDATGKFVSNWDSETKQRVSLSLTSTAWRLLDVEAHKRGISRSEVIEQIARSLESESENTALQERIIEQQQAIATLQHQKQELETLLENAPDAIARFDAHIRYLYVNRIVEQALGFPRDALLGKSMSEFMSDPIYLFWEEHLRQVFATAQPQEIEFEFQTSWGLRFYQARLVPELDAEGTPISVVVISRDITEARKAQQQHSQLLAAQETERQVTTILESITDAFVAFDREWRYVYVNHAAAAILHQTPAKLIGKHVWNEVFPELVGGFGYQQLHRAVKEQVPVSWEEFGEPVQCWLEVKAYPSAQGLAVYFRDITERKQVEAEKERLWQELEIERTRFEAVLRQLPVGVLIADATSGKLILANEQAKQIVRYDYEQSLELEEYLPVTPFAAFDRDGRLYEAYEYPLARSLFTGEAIANEEMGLHQTDGSHIFINVNSAPILDRQNQIVAAVAVFQDVTARKQIEENLRQTEERLQLALSSAQMVAWDMDLITNYVVCSPNAPSVWGMQAGTTEEFFAVIHPDDRQRIVQAAQTAIAGESSYEQEYRVIAPDGVVRWLNSQGQVYLDETGRGIRITGVTVDITERKQIAAERDRFLAQEQATLQKLQRKEKQQQFLIELNDAIRAIQDSKEIMWRVVSSTGEHLNVTRCTYGEIDSTQEYVIVDRDYCNGVMSVAGTHHMNSFGPELIAELKQGKTIVVDDVDLDPRTMGAGAAAFAAIQTKSLLCVPLVKAGRFVALFVLHHIDPRHWTEDNVELMERIAQKTWLAVERSRAEEELRESEAHLQVALKVGRMGTWNWDMQTRTLVWSEGHFTILGLQSHRCKPSYKAWANQVHPDDLAETRAKFQQAMSEKKEYHHEYRLRWADGSIHWVEARGKFTYDSQGNPKHSIGAVLDITERKQAEQEKEQLLERERIARTQAEAAQNQLATIFETSPVGLALLDAEQRFIAINEALAEINGLTRDQHLGRSIPELFGQSDPKVVAVFHEIYTTGHPFISPNFAVKVPGRRDRCPGYFNVYYLPTTNSHHQVEEVLVYVVDVTERVQLERGQRFLAEASAVLASSLDYQTTLELVAQLAVPELADWCTVHVVAENGAIEQIAVAHADRAKLEWAHKIRQKYPLNPNASHGAALTLRTGQPQLFSDIPDDLLVQTAQDLEHLEILRQVGFKSAMTVPLKSQERIFGVISFISAESGQSYDQKNLQLAEELAHRASLAIDNAQLYQLAQRDRAKAEAANRVKDEFLAVLSHELRSPLNPILGWTKMLRSKHLDATKTDQALETIERNAKLQAQLIEDLLDVSRILQGKMTLNVAPVNLAAIIEAALETVRLSAEAKNIQIQTKFNSISGNVVGDANRLQQVVWNLLSNSVKFTPLAGRVEVHLEQVGIYAQIQVKDTGIGIKSEFLPHVFEYFRQEDSTRTRKFGGLGLGLAIVRHLTELHGGTVQADSPGQNLGATFTVRLPLNVVEQELSSNHTHLETVADLKGIQILVVDDDADMRELAEFILTESGAQVTTAASAVQALTLLNQSLPDLLLCDVGMPEMDGYSLIRQIRKWAPQQGGNISAIALTAYAGEINQQQALAAGFQMHIAKPVDPEELVQAIVQLLHPIG
>NZ_AP018172.1|WP_096588624.1|2730750_2732928_-|hypothetical-protein
MVAHSVWIVGSSRSGKTTRLVNQFCSWVQGNHQANGSFYTNQKEQKKGKQLVKGLELRQAEPGVLLLAANDDNRREFGDRIVTATLGKYPVRAKTPLGFFQDEVILFWPLLIQSLNLNAQFPVRLRPETEQELATKLWRSQLDEETLRQAGMNEYRLVRRILDLLQLAAYSGENCDRIAEILATGLGDNPIDLDPEFLASLLLDWRDWCLNRGFLTYGIITELYNRHLLTNENYQQHLAKRYQAVLADDVDEYPGVARHLFDFLLDGGAVGAFSYNPEGAVRLGLGADPQYLEGLARRCQVETLIGPPVESLAIELATQMVELATEPTVILSLPETVQSIQTTSRAQLLRQTAEVIVDAIASGEVEPEEVAVIAPGLDAIARYTLIEILNKQNIQVEPLNDQRPLISSPAIRALLTMLALVYPGLGRLVDRDAVAEMLVVLSRKSKAADSASELSTNIDPVRAGLIADYCFEPHPERPNLLPVTAFERWDRIGYAATTAYTEILQWIEKQRSQQEQRLIPSPISLIYLAIQDFLCKDTNPPYDRLAALRELLETAQHYWEINTRLQQTNSKLPPSIPSESTIAEFIQLLRRGTITANPYPLRPIGPARKAVTLATIFQYRSSRRFHRWHFWLDASSPLWAKGGAATLFGAPLFLQHRLGSPWTAEDEKLAEEQRLQRILADLLSRVSEKVYLCHSDLAVNGQEQLGPLLHLVNACVPINSEAVVN
>NZ_AP018172.1|WP_096588625.1|2733015_2734326_+|proton-extrusion-protein-PcxA
MKNSVFSQKIYPFLLSLYRWYLRTPERSLDEAYNAALKIKELEDKHFNGNKVDPDLAMYSSNVMDYFQADLKKQLKIARMRLTEFKGSRWFLNEGNQEAANKAGVEYPDLALILEKLRFIDGVLSKYTNVENEVNSLVVVDQTPKIPTNSVIAQTSTPKLPNNNRRKPQGKADTTGILPRSILSTITRLQVELDPNSEQDVVQNFRQTQRRTIISIRFLLLLIIVPLLTHQVAKALVVGPLVERFRGSEAIQIFLNVEMEEEALAELERFEERIKFENLISKAPPLSSEELETHMKEKAGEIAEEFREESSNAIKNVFSDIFSVGAFIWLLLVSKPSIAIIKEFFDNIVYGLSDSAKAFIIILFTDVFVGFHSPHGWEVILEGVSRHWGLPANRDFIFLFIATFPVILDTIFKYWIFRYLNRISPSAVATYHNMNE
>NZ_AP018172.1|WP_096588626.1|2734377_2735685_+|murein-transglycosylase-A
MFDFIFKRKGTQRFTQRNAKVLLQLFACLPLVLGILLVRMPSLEYRGLSVPECQVKKWHLPEALSSNSQEKAPVLIQRLPVTCCQNDRSCVDEALYGAQNDKKALLTSIDRSLRYLQSARGDDAYKSYPIPRITRDRVYKSLLRFRQLLLNTNSAAALQTAIAKEFVLYQSIGKDSKGSVLFTAYYEPLYTASRVPTAEYRYPVYKAPPDLDSWSLPHPTRLELEGADGLQGEKGKLRGLELFWFRDRLEPYMVQIQGSAKLQLTDGTQTSIGYAGNIAYNYKSIGRELANDGKLPLEGMTMPVILDYFQKHPQELNVYIPRDPSFVFFQETKGAPAQGSISQPLTAERSIATDKSLMPPGALALIRAAFPFPDNSGKLEHRIVSRYVLDQDTGGAIKGPGRVDYFLGTGKLAGDRAGVTVSNGQLFYLLLKAKN
>NZ_AP018172.1|WP_096588627.1|2735917_2736373_+|hypothetical-protein
MLKILVDADLILEALMNRNNFVEDVGKLLDIIHPVMQIYITDVGWQKIYNYLRCLQNTQIAELVVNWLQEKIQICPIDNSILQQARSSPVKDFESAVELVCVSQRQLHAIVTHKPENFAEAPHKFGIWSIADLWLRANLELRYIHTDKIIH
>NZ_AP018172.1|WP_096588628.1|2736470_2737058_+|HD-domain-containing-protein
MTINRLTQQIQFIIEIDRLKQVLRQTLLVDGSRQENSAEHSWHLAVMAMTLAEYAPVEVDIFHAIKMLLIHDLVEIDAGDTFCYDVQANSSKAEKELQAASRLFGILPPDISSELRLLWDEFEVGETPTAKFAAALDRIQPLLHNQQTKGGTWRIHGIKRDQVMKRVAPVETGAPQLWPFVLQLIDDCAAAGYLG
>NZ_AP018172.1|WP_096588629.1|2737136_2737988_+|S-formylglutathione-hydrolase
MTDLKLTSEYQCFGGKVGFYSHFSSSCNGEMRFSVYQPPQATQEPVPILYFLSGLTCTEENFMVKAGAQRYAAEYGLMLVAPDTSPRNTGIPGEDDDWDFGTGAGFYVDATVQPWRSHYQMYSYVVQELPSLITANFPTQAEKQAIFGHSMGGHGALVCAMRNPQLYKSVSAFAPITAPMRCPWGQKAFSGYLGTDRETWRSYDASELVKQLGYHSPILIDQGTTDKFLAEQLQPELFAQACAEVKQPLNLRYQAGYDHSYYFIASLIADHIRHHAIALNSTQ
>NZ_AP018172.1|WP_096588630.1|2738159_2748440_-|non-ribosomal-peptide-synthetase
MVLNFVSDNNIQELNNSGSNIYWAVRLSGYLKVDILQQALNAIASHHPPLRSHFNEEDTQSVELKAIDLQKYLATESELQVKRFLQQESQRSFDSASNLMLRACLLQLNEQEQILLLVTHPKASLPMNMLWEELAHVYQALLEGKLHPLSQLPNQYTDNNVGQDHLNYWKKQLAGAVPVLELPSDRPRPPIQAYQGARKSMVLPQELTKSLKHLCGQQKVNLFMTLLAAYQTLLYRYSSQEDILVGSATRGYYSESIDTLIFRTHLSDHLTFIELLDRVRSVVLDAHTHENLPFEQLLKELKIESSPSYHPLFQVMFNFQEQHQQISQLPGVTATPIGLEIGLTKLDLIITVREENETLLGIWEYNTDLFDDATISRMVRHFQNLLAGIVAHPSQQISLLPLLSADEQQQLLNQWQHTQVDYPYDSCIHKLFEAQVELVPDAVAVVYENQQLTYRELNIKANQVAHYLQNLGVGSDVLVGICVERSLEMIIGLLGILKAGGAYVPLDPNYPVERLAFILEDAQVSVLLTQERLLEHLPQNQAQVLCLDREILATYSSENPTISVTSANLAYIIYTSGSTGKPKGVLINHSNVVRLFNATEHWYHFNQEDVWTLFHSFAFDFSVWEIWGALIYGGRLVLVPYLVSRSPEAFYELLCQEKVTVLNQTPSAFQQLIRTEQTIANSGELALRWVIFGGEALELQSLKPWFDRHGDESPRLVNMYGITETTVHVTYRPITTADLIEGAGSVIGCPIPDLQVYVLDRHRQLQPIGVPGEMYVGGAGLARGYLNRPDLTAKAFISNPFSNDPQARLYKTGDLARYLPNGDLEYLGRIDHQVKIRGFRIELGEIEAILNQHPTVQQTVAIAREDVPGDKRLVAYIVPKTSTIQIPELRRFLKEKLPEHMIPAAFVMLDVLPLTSNGKVDRRALPVPDASSVSSSADYVAPRNPTEEILATIWAQILGLERVGINDNFFELGGHSLLATQVISRLRQALKVEIALRSLFAHPTIAELAQVVDEYQSKDSNFQLQRITALTNSDSLPLSFAQQRMWFWEQLQPGSSIYHLPEVRELKGDLNITALQQSLDAIVARHEALRTNYIVQDGNPVQAIQLPRAVELLRFNLQDIPESDRSTQIEQILQQQTQRPFDFASDLMLRGCLLQVNEQEHILLLVMHHIASDGWSMNILWQELADLYLAFVSGQPNPLVELPIQYADYAVWQRQWLEGEVLETQLNYWQQQLAGAPPVLELPTDRPRPPIQTYQGAGQSFTLSGELSQALQKLSRQEGVTLFMTLLAAFQTLLYRYSRQEDILVGSAIAGRNHPEIEGLIGFFVNTLVMRTDMSGNPSFRELLRRVRQVASSAYAHQDLPFEKLVEQLQIERSLSYHPLFQVMFILQNTPNQDLQLPGLSAVPLEIDSDKAAFDLILEMFETPTGIKGKIQYNTELFDAAAIARTIEHLQTLLAGIVAHPEQNIATLPLLTASEQHQLLRQWNDTQVDYPQQCIHLLIEQQVERTPDAVAVVFHHQQLTYQELNQRANQLAHHLQNLGVGPEVLVGICVERSLEMVVGMLAVLKAGAAYVPLDPAYPQERLAFMMSDAQVQVLLTQEQLLTILPKHQATVICLDTGWKEISQYPQSQPVSNVQLSNLAYIIYTSGSTGKPKGVLVTHKGLCTLALAQIKKFSVQPSSRILQFASFSFDASIADVLMALCAGARLCLAKKEALLPGADLMQTINEYQISHVALPPSALAAMSNQSLKSLQAIIVAGEACKTELAAEWSSRVRFFNAYGPTESTVCATMAEYTDANQKLTIGRPIANSQIYILDTHLQPVPIGVAGEVHIGGIGLARGYLNRPELTKEKFIPNPFSKKIGSRLYKTGDLARYLPDGNIEFLGRIDDQVKIRGFRIELGEIEATLAQHPLVQQAVVTVREDIPGDKRLVAYIVAQSQPAPTTSEWRSFLKQSLPDYTIPNAFVVLETLPLTPNGKVNRRALPEPDTESVNLATDYVAPSTPTQEAIAAIWKQVLGVEKIGINDNFFDLGGHSLLATQAISYIRQAFQLEIALQSLFAQPTIAQLAQFIDQQAQNTQQLQQIPKANRESIPLSFAQQRVWFLEQLEPNSSAYIIIDAQRLQGKLNIEILQQSLDAVVAQHEALRTTFIPGDDGSPIQVINPPRPVELKIIDLRSHSQPIEQVLNQEALQPFNLASDLMVRATLVQIDTEEQILLLTMHHIASDGWSIDIFWQQLTAVYAALLQGRPSPLEPLPIQYADFAVWQREYLSGEVLQTELDFWKNQLAGAPTVLELPADRPRSPIQTYRGASQALSLSSTLSAALTTLSRQQGVTLFMTLLAAFGSLLHRYTGQSDILIGSPIAGRNRAEIEQLIGFFINTVVLRTKFADDPSFTELLAQVRDVALAAYDHQDLPFEKLVEELHVERDTSRNPIFQVWFNMLNLGDRQIELPGLNVESVSSVEAPSKFDLTLYVLEQQQGIQLQLVYNADLFNAERMQEMLRQFQHLLTQIVAIPQQSISSYSLVTPTSQALLPQPRVILPQPDYELVTTAFTAWVNRSPEHTALRQSDRHWSYQELGDRATNIAQTLVAIGVKPGDAIAIFGTKSFGLIASTIGILLSGGVLLTIDPQLPSYRQELMLQAAQAKYLIYIDGEYPEASELWQSLTLIYVDSHLGKVINPSLDDNREVELPQIQPDDAAYIFFTSGTTGVPKGVLGCHKGLAHFLTWQRQTFNIGQQDRVAQLTGLSFDVVLRDIFLPLTSGATLCLPEPGDNLDPTKILHYLEQEEISVMHTVPSLAESWLVNVPADVSLQNLRWLFFAGEPLKQILIEQWRKAFPTSGEIVNLYGPTETTLAKCYYRIPEEATSGVQPIGLPLPQTQALVLTSHHQLCGIGELGEIVIRTPFRTKGYINATAENLARFVKNPLSDDEQDWLYYTGDRGRYRPDGLLEILGRQDHQIKIRGIRIEPGEIESVLTQHPEVLQAVVIAREDIPGDKRLVAYITAKDAAPSISDLRRFLSSKLPQYMIPSAFVLLDTLPLTPNGKVDRRALPAPELSRQEPEATFVAPRNQVENQLVEIWQQVLAVESIGVRDSFFELGGHSLLAVKLFWQIEQTFGQRLPLASLFQSATIETLAEIISPQAEQKQETSPTTWSSLVPIQPHGSKPPLFCVHGLGGEVLCFRELAMYLGTDQPFYGLQPQGLDGEQPPLNKIEDMAAHYIREIQTLQPQGPYYLAGYSFGGNVAFEMAQQLHRQGEKVGMLVLLDTSRPGSENRLPLIQRIGEHLQNLVQIGPSYLWHRMGVWRDWILSNLNESKSRLNKKYKNYLDVEPDYVSKLTQNMSEADHYLEIIDANAEAISQYSFRVYPGRAVLLRTDDRSRVDAIGIQYDPQFGWGELVAGGLDMEYIPGSHFDFLNEPHVRFVAQKLRHFLSKAMEV
>NZ_AP018172.1|WP_096588631.1|2749610_2749832_-|hypothetical-protein
MYSSKVEKMAGRSEQRTLIRENTILAAKNFLAKMDNDATPEELDMIANSVGEIALFWHLIGNPEEISAMELQV
>NZ_AP018172.1|WP_096588632.1|2750377_2751022_+|nucleotidyltransferase-family-protein
MDFTTEQIETENSTIAVMILAAGASTRMGTPKQLLPYQGRSLVQYITEIAIASVCHPVVVVLGAYAEQIRPEIARLPISIVENLDWARGMSTSINRGMQFLQNQPQNIEAVVILVCDQPFISTQIINRLVEAYHSTKKALVSCEYAGTLGVPALFNKMFFSELAALSGNRGAKQIINNHLDRVFSIPFTLGNIDIDTPKDYEQLLTIISNENIY
>NZ_AP018172.1|WP_096588633.1|2751327_2757327_+|AAA-family-ATPase
MSITIAGYNIVQVLYEDNTTYVYRGVRKLDTSSAIIKTLKSEYPTIEQLARLRYEYQILQSLDIEGIAKPLGLENYQNGLALILSDFDSETLKNFIDSRKIELINFLQIAINLASTVARLHKNNIIHKDIKPQNILVNPKTYQVKIIDFSISSRLSRESHNIINLNQIEGTLAYMSPEQTGRMNRSIDYRTDFYSLGIAFYEMLTGQLPFSTTDPLELVHCHIAKTPITPQEINLNIPQAVSDIVMKLLAKTAEERYQSALGLKADLEECLRQIQAIGKIENLTIGQLDLYSQFLIPQKLYGRETEVAILMNAFERVSLGAAEFMLVSGYSGIGKSSLVNEIHKPIVSQQGYFISGKFDQLKRNIPYAALIQAFQDLMRQLLTESTDKIAIWQTKLLAALGSSGQVIIDVIPEVEEIIGSQPDIPQLGLTESQHRFNRIFQQFIHVFCKLEHPLVIFLDDLQWADSASLKLINLLLTNGNSQYLLVIGAYRDNEVNVTHPLILTVEEIQKSGAVVNNIILQRLQIANVNQLVSETFHTQQENSKQLANLVYNKTQGNPFFLTQFLKTLYQEKLLKFNFSKGYWDWDIELLKDIDITDNVVDLMVDRIQKLSTITVNILSLAACIGDKFTLDILSIVNQKSLSETATDLWEALQAGLIIPLSQSYKIPLVVTVEQNELLTADKDQLTIAYKFLHDRVQQAAYSLIADSQKQATHLRIGQLLLQNTPIDARKENIFALVNQLNYGIDLLTLDSEKYELAELNLIAGQKAKAATAYDSAVRYFKVGLRLLPVNSWYQRYELALALHQEAAEAAFLSGDFEQMEQLIKVVLQQATTQLDTVKVHELQIKSCEVQRKLLEAVKLGLQVLEMLGVKLAESPNALDIQKAIAETTANLTEKSIENIINLPPMTDAEKLAAFRLIVSLVPAAYQSAPSLFILMACQQVNLSVLHGITSFSVSGFADYGIIFSGLLQDIEAAYKFGQVALNLLEKLDTHEVRSQTLFKVATFLLHWKYHVRETLPLLEDSYHSGLEYGDLIHSGYAASNKCQYSYWTGSELQSLAQEMARYSKAIAQINQETALKWHQIFHQAVLNLIGESENPCVLVGEAYNEEEFLPLHIQFNERTVIHYVFLNKLILCYLFGEFSQAVESAIKAEQYLDGVIGWLIVPLFHFYDSLAQLAIYPSLPQSQQEQLLNRVVSNQEKMRKWADHAPMNFQHKYELVEAEKARVLGEYWQATECYERAIAGAKEQGYLQEEALANELAAKFYFERGKEKIAQIYLTDAYYRYMRWGATAKVKALELKYPQILSQISNAKDAILEVNQTISYTTANDRGVFDFAAVMKASQALSGEMVLDKLIAKLMQIVIEIAGAEIGFLILEESEKLFIKASGNIQEDEITVQQPIPVESSEQLPVSIINYVHRTQQYIVLNNATSQGVFTTDSYIINRKPKSILSTPIVNQGKLIGILYLENNLTVGAFTPQRLEVLQLLSSQAAISIENARLYNDLEEYNRTLAVKVEERTLELQDKNLQLQQEIGDRQRAEEVAEAANRAKSEFLASMSHELRTPLNGILGYTQIFQKDKTLSAQQKNGINIIHQCGEHLLTLINDILDISKIEARKMELYPKEFDFPEFLESIVQICRICAAQKGVVLNFKALSSLPKAIRADEKRLRQILMNLLSNGVKFTEEGTINFAVGYQNGKLRFQVQDTGIGIAQKQLEEIFLPFKQVGEYTRKTEGTGLGLAISSQLVQMMGGELKVQSTLGKGSVFWLDLDLPQVCEETEIKSINENNIISFVGTKNKILVVDDKWQNRSVLISLLQPLGFEVIEAIDGQDGLNKAQVFQPDLIFMDLVMNVMDGFEATRRLRMSADFKEVVVIALSASTFDFDKEQSQEVGFNDFILKPFKLSELLEKIGLHLQLEWVYEEVSSGKQEQEDKNIKAKIPNREFIIPPATEVAILLDLAKKGDIRGVIQQAEKLKELNEQWLDFASHVIQLAKGFKGKQLREFLKKY

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Crispr_ID: NZ_AP018172_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_8

3086392-3086944

Orphan

Consensus_repeat	Method
GTTTCTACCAACCATTTCCCCGCAAGGGG-------ACTGAAAC	PILER-CR
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	CRISPRCasFinder
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	CRT

7 spacers

The CRISPR arrays of NZ_AP018172_8

>merge|NZ_AP018172|8|3086392-3086944|PILER-CR,CRISPRCasFinder,CRT
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAACTTGAGGCATACGGGAGTAATGGCGGGTTGATGTTCCGTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAACTCTCGCAGCTGCTACAACAGAAAATTGGCACAATAGTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAACAATCATTCGCTGCTTGGCAATTTCCTTCTTGAATACCACAGCAGTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAACTTAGCTCTATGCACTTCACGATCGCCTATCCAAACAGTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAACCGGCATTCTTGCGAGGGCGACCTCGTTTTTTAGTTGGTTTCTACCAACCATTTCCCCGCAAGGGAACTGAAACTTCACTTCGTGCTGTTTTTTGCCTTTCGCACCTTTGTTTCCATTAACTATTTCCCCGCAAGGGGACTGAAACATACCGTTAAGCCCAGTGCTGGGTTTATCTAAAACTGTTTCCATCAACCATTTCCCCGCAAGGGGGCTTAAAC

>NZ_AP018172|8|6|3086392-3086799|PILER-CR
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TTGAGGCATACGGGAGTAATGGCGGGTTGATGTTCC
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TCTCGCAGCTGCTACAACAGAAAATTGGCACAATA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	AATCATTCGCTGCTTGGCAATTTCCTTCTTGAATACCACAGCA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TTAGCTCTATGCACTTCACGATCGCCTATCCAAACA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	CGGCATTCTTGCGAGGGCGACCTCGTTTTTTAGTTG
GTTTCTACCAACCATTTCCCCGCAAGGGAACTGAAAC

>NZ_AP018172|8|7|3086392-3086944|CRISPRCasFinder
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TTGAGGCATACGGGAGTAATGGCGGGTTGATGTTCC
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TCTCGCAGCTGCTACAACAGAAAATTGGCACAATA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	AATCATTCGCTGCTTGGCAATTTCCTTCTTGAATACCACAGCA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TTAGCTCTATGCACTTCACGATCGCCTATCCAAACA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	CGGCATTCTTGCGAGGGCGACCTCGTTTTTTAGTTG
GTTTCTACCAACCATTTCCCCGCAAGGGAACTGAAAC	TTCACTTCGTGCTGTTTTTTGCCTTTCGCACCTTT
GTTTCCATTAACTATTTCCCCGCAAGGGGACTGAAAC	ATACCGTTAAGCCCAGTGCTGGGTTTATCTAAAACT
GTTTCCATCAACCATTTCCCCGCAAGGGGGCTTAAAC

>NZ_AP018172|8|5|3086392-3086944|CRT
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TTGAGGCATACGGGAGTAATGGCGGGTTGATGTTCC
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TCTCGCAGCTGCTACAACAGAAAATTGGCACAATA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	AATCATTCGCTGCTTGGCAATTTCCTTCTTGAATACCACAGCA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	TTAGCTCTATGCACTTCACGATCGCCTATCCAAACA
GTTTCTACCAACCATTTCCCCGCAAGGGGACTGAAAC	CGGCATTCTTGCGAGGGCGACCTCGTTTTTTAGTTG
GTTTCTACCAACCATTTCCCCGCAAGGGAACTGAAAC	TTCACTTCGTGCTGTTTTTTGCCTTTCGCACCTTT
GTTTCCATTAACTATTTCCCCGCAAGGGGACTGAAAC	ATACCGTTAAGCCCAGTGCTGGGTTTATCTAAAACT
GTTTCCATCAACCATTTCCCCGCAAGGGGGCTTAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096589001.1\|3095116_3095500_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_AP018172.1\|WP_096588981.1\|3078979_3080098_-\|sensor-histidine-kinase-KdpD	unknown	unknown	gnl\|CDD\|225115
NZ_AP018172.1\|WP_096588989.1\|3087248_3088751_+\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|215283
NZ_AP018172.1\|WP_096595240.1\|3085248_3085995_+\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237827
NZ_AP018172.1\|WP_096588977.1\|3076556_3078500_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225885
NZ_AP018172.1\|WP_096588993.1\|3090273_3090696_-\|DUF3011-domain-containing-protein	unknown	unknown	gnl\|CDD\|371422
NZ_AP018172.1\|WP_096588987.1\|3084089_3085007_+\|ferritin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|153097
NZ_AP018172.1\|WP_096588976.1\|3075591_3076194_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP018172.1\|WP_096588983.1\|3080400_3082776_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP018172.1\|WP_096589006.1\|3098580_3099996_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP018172.1\|WP_096588999.1\|3092883_3094773_-\|lipoxygenase	unknown	unknown	gnl\|CDD\|366014
NZ_AP018172.1\|WP_096588997.1\|3091440_3092790_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_AP018172.1\|WP_096588979.1\|3078552_3078873_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_AP018172.1\|WP_096589003.1\|3095649_3096552_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_AP018172.1\|WP_096589005.1\|3096864_3098373_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225885
NZ_AP018172.1\|WP_096588985.1\|3082897_3083803_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376282
NZ_AP018172.1\|WP_096588972.1\|3073898_3074792_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP018172.1\|WP_096588991.1\|3088942_3089839_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_AP018172.1\|WP_096588995.1\|3090850_3091417_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096588974.1\|3074806_3075580_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096589001.1\|3095116_3095500_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	5.31429e-24
NZ_AP018172.1\|WP_096588981.1\|3078979_3080098_-\|sensor-histidine-kinase-KdpD	gnl\|CDD\|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	3.56187e-178
NZ_AP018172.1\|WP_096588989.1\|3087248_3088751_+\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|215283	PLN02518, PLN02518, pheophorbide a oxygenase.	4.4641e-76
NZ_AP018172.1\|WP_096595240.1\|3085248_3085995_+\|isoprenyl-transferase	gnl\|CDD\|237827	PRK14832, PRK14832, undecaprenyl pyrophosphate synthase; Provisional.	1.69648e-175
NZ_AP018172.1\|WP_096588977.1\|3076556_3078500_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|225885	COG3349, COG3349, Uncharacterized conserved protein [Function unknown].	8.85139e-65
NZ_AP018172.1\|WP_096588993.1\|3090273_3090696_-\|DUF3011-domain-containing-protein	gnl\|CDD\|371422	pfam11218, DUF3011, Protein of unknown function (DUF3011). This bacterial family of proteins has no known function. Most members belong to Proteobacteria.	3.05502e-10
NZ_AP018172.1\|WP_096588987.1\|3084089_3085007_+\|ferritin-like-domain-containing-protein	gnl\|CDD\|153097	cd00657, Ferritin_like, Ferritin-like superfamily of diiron-containing four-helix-bundle proteins. Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).	0.000934244
NZ_AP018172.1\|WP_096588976.1\|3075591_3076194_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.97964e-18
NZ_AP018172.1\|WP_096588983.1\|3080400_3082776_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	9.56252e-09
NZ_AP018172.1\|WP_096589006.1\|3098580_3099996_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.32441e-18
NZ_AP018172.1\|WP_096588999.1\|3092883_3094773_-\|lipoxygenase	gnl\|CDD\|366014	pfam00305, Lipoxygenase, Lipoxygenase.	7.09762e-54
NZ_AP018172.1\|WP_096588997.1\|3091440_3092790_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.35162e-14
NZ_AP018172.1\|WP_096588979.1\|3078552_3078873_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	1.25561e-28
NZ_AP018172.1\|WP_096589003.1\|3095649_3096552_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.24778e-25
NZ_AP018172.1\|WP_096589005.1\|3096864_3098373_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|225885	COG3349, COG3349, Uncharacterized conserved protein [Function unknown].	4.28287e-161
NZ_AP018172.1\|WP_096588985.1\|3082897_3083803_-\|hypothetical-protein	gnl\|CDD\|376282	pfam18863, AbiJ_NTD4, AbiJ N-terminal domain 4. Alpha + beta. Found fused to AbiJ-like HEPN and heat repeats.	7.22077e-18
NZ_AP018172.1\|WP_096588972.1\|3073898_3074792_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.34262e-97
NZ_AP018172.1\|WP_096588991.1\|3088942_3089839_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.1335e-33
NZ_AP018172.1\|WP_096588974.1\|3074806_3075580_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.54477e-13

>NZ_AP018172.1|WP_096595240.1|3085248_3085995_+|isoprenyl-transferase
MNPLPPDLNPEKIPQHIAVIMDGNGRWATSRGLPRIAGHRQGASTLKQLLRCCKDWGIKALTAYAFSTENWQRPIEEVDFLMHLFERLLRRELAQMHQEGVRISFIGDLSALPPSLQTEVERSMIETLNNQAIHFTVAVNYGSRNEITKACRQLAQLVQQGQLSAEAIDESLVEKHLYTADTPAPDLLIRTSGEMRLSNFLLWQMAYTEMYFTDILWPDFDREAFHQALLSYQKRDRRFGQVKPLLSA
>NZ_AP018172.1|WP_096588987.1|3084089_3085007_+|ferritin-like-domain-containing-protein
MLNTASPQIETSGAQSWQIQRRIHSLIDNYLADEKLRDRLQDLPLQFSNPQPRPWKPIDWQAINRNQIIGINPEVFLSILIGAMDTEAPIRAYTQTSRQYLEKLHPHMARFVGGTVSEGGELQEIGLWEKEERQHTPALMKVYTQLTGEKITPKHRIVRGYIPTDDPQEDLYRHGLHRVATEYGATCLYLWLMAHTTDALQDVLEELAKDEINHMTKFWGFGVWAFPDTGLIRVGKTLIKTRSQTYQRNNLIRTLRRMMATLNWNAWTFTNKATLLYTFTHTMHRLWTWHNSLTPEYLNNLLETR
>NZ_AP018172.1|WP_096588985.1|3082897_3083803_-|hypothetical-protein
MKVYDIFSKRQKRLRGEFPDVYQYVDIPQPLRVQIFYILNDVIAAPIDLHFMKGFSEIYSRLYREYGKLQQAIVGKDIINLFLFNTQVTEHILDFIELSFQLIDTTYRRSITVNENFSKITADEAIAELNFRFREHGVGYQYESGKMIRVDSQIIHTEAVKPVLHLLSDTRFQGANEEFLKAHEHYRHGRYKECLVECLKAFESTMKTIFDSQGWSYQSTDTAKKLIDICFQNNLIPAYLQTQFTSLRSNLESGIPTIRNKNAGHGQGSQLITIPQHFAAYQLHMTASTILFLLEAERTLP
>NZ_AP018172.1|WP_096588983.1|3080400_3082776_-|tetratricopeptide-repeat-protein
MDAEAALAWLDTIIPAQTGERLSDLQKVILQQVWLGRKYLDIAHAYGCTEGHVKDVGSQLWKLLSQVLREKVTKSNCRATLERILRKAAAISSQIDRSQPPQVSIIKPEDSNFLGREDAIAHLTSLVNQGSKVIVIQGEGGLGKTTLAQQYLQTQGFELVLELLMAKETHNITSAQRVVEEWLKQDFGEEPGVEFGVTLGRLKRLLHQRRIGVLIDNLEPALDGKGKLIPPHRNYLELLRILADVRVQSVTLITSRDRLCEPELNVHHYRLPGLDGSAWLKFFRNQGLTVNLPSLQQIHHTYGGNAKAMGILCGAMQADFGGDMALYWQQNHSDPLAATDLKNLAVSQINRLQALDPQAYHLLCRLGCYRYQDIPTIPIQGIFCLLWDVPPAEHLQIIASLRNRSLVECDRGEYWLHPVIQAEAIARLRLSDEWQITNHKAAEFWTASVTQIATFKDALQALESYYHYIEINEFELAGKVLLKSRHNQWQQFLPLGSTLYRMGLIQPILTAINHILTHIEAEQNIIELYNILGDLYWITGDIDRALNCQENTINLAKQALKSLVPQSENKHKVYYLRMLEVDSLLSIGLYKIDLWELEAAFELFQQVIYLAQNTAHHRWAEKASVCLALVNSYLGLYDAAHELANAAYEHLKNEQSIETGSFAYFMQILGQTYVNLGDLSKANQIFHQVLNFAEASHYMQVKAKTLNGLAEIYRQQADYQLALAHHTEAIELLDKIGAKCDLAEAYFQLGLTYQKLDKAGESQMYFHQAMQLFAEIKAPKQVAKISILTRV
>NZ_AP018172.1|WP_096588981.1|3078979_3080098_-|sensor-histidine-kinase-KdpD
MLNNSTSSPDNSYIRPYRRGKHKIFIGMAPGVGKTYKMLEEAHQLKQDGIDVVIGILETHGRKETAQKATGLEVIPRKTSSRENVTLEEMDTDAILLRSPQLVLVDELAHTNVPGSPREKRYQDVEAILAAGIDVYSTVNIQHLESLNDLVARITGVVVRERIPDRLLDEADAVVVIDVTPETLEERLLEGKIYAPEKISQSLDNFFQRRNLIALRELALREVADTVEEANTSTLEGQNCNIHERVLVCVSTYPNSVQLLRRGARIANYMNARLYAIFVADPERFLTKQESLHIHTCEKLCKEFSGEFLHVKSHNVAQEIAQVAAKYHITQIVIGESQQPRWKRWFKLSFTQRLMELIRYQNIDLHIIATDK
>NZ_AP018172.1|WP_096588979.1|3078552_3078873_-|multidrug-efflux-SMR-transporter
MLISWIYLVAAVLFEVIGTTCMKLSQGFTKVTPSILVFTSYGLCLTFLTLSLKKIEVSVAYSFWAGLGTTLIALIGIFWFRESMSSVKFISIILIVIGVIGLNSGK
>NZ_AP018172.1|WP_096588977.1|3076556_3078500_+|FAD-dependent-oxidoreductase
MSQLSNSPESSTISRRTLLKWFGIGSIAGVTGYSRFSKPKPTVFQRDTLQLPRMLNQGKSVVVIGAGLAGLACAYELSQRGFAVTLLEKSPQLGGKIASWQVEAVGETFMMEHGFHGFFPQYYNLNGLVTELGINEHFQSLNFYSVVYRDRKYQPEVFRPSRSAFPWNIIDLAIASPNRFQWGINLINLKHLQVFQAITGFQRERNYRRFDNISVADWVATEFPQGLYDLYFLPFAKSSLNAPDLMSVGELMQFFHFYFFGNPEGLAFNGTKDDMGTSLVQPIAQTILSNGGKIITDATVSEISAVQGKINSLKYFDGNNNNNVVPFSVKRNSVVADEKIEYFGAADEVFAAPKGSKEAISLTCTHQGCTVKKAEDGKFHCPCHGAVFTADGKVLKGPAQRDLTKFKIVARQDEELQLVAANPESSSPQAIAADYYVFATDVPGVQQLFKRINGDVDKKVRSQVEKLSIADPFAVCRFWFNRDFQWEQSNFTSLSGYQLTDSITLYHRIQEQFIDWANRTGGSVVELHAYCYKEKEFPNQEALLNTFEQELYEIVPELKQAKVLHRELVNQHNFSGYPPNSYAERPETSTSIANVIFAGDWVKMPFPCGLMERAVSSGLLAANEILSREGLQRRSLLSVNPEGLLQI
>NZ_AP018172.1|WP_096588976.1|3075591_3076194_-|TetR/AcrR-family-transcriptional-regulator
MPDDRNSPKQVPSSGRERILDEAEQLFRARGYNSVAMRDIAQAVGIRQASLYYHFPSKEQLFVAVTERMFERHRLGIQQAIGEHEDNLRSQLSAIGAWFISQPTIHFLSMVHTDMPLLDEENTARLSACSTKCIFEPICQIFAQAQQRGEIRTVRPQLLAGFFLSVMESLPLAATLADAVPKQTIVNEMISVLLDGLKLQ
>NZ_AP018172.1|WP_096588974.1|3074806_3075580_-|ABC-transporter-permease
MKYLREIIAVSQRILIELLRRRRSLIFWSIFPISVLIISGFILAERAQLPLTSAFAYAAPSSLVGAAMFFSCLGGSVATVVAEREQQTLKRLFLSPLSGTSYFLGIFLAHSCIGLGQTLLIYTVAAFWGATFKGSILLGLIIILMTIIAYVGLGFILGTQLARRIEDVNALVAAFGVPLLILGGAFLPATLFPPTLINIAKFNPIYHMNESLVAVSAKGEGIADISSHFWFLLIFSIAMFGCGWFAYRRMLIVERRL
>NZ_AP018172.1|WP_096588972.1|3073898_3074792_-|ABC-transporter-ATP-binding-protein
MLTIKNLNKSYRKRQVLQNLNLHIASGEIYGLIGANGAGKTTTINIICNLLKADSGDIQINHQPVSESTKKLIGVAPQENILYKTLSCEENLKFFADIYGLNRKERQRMIAETLVAVNLIDRAKHPVETLSGGMQRRLNIAVALVHQPQLVILDEPTTGLDIEARYEIWELIRQLKNQGITVLLTTHLLDEAERLCQRIGILKNGHILAEGSLAELRRLIPAQEVILVQTEFEEQAIARAKEYGFAHRRYGSDLAFWLPEPLELKEIIARFEGIAINSIARQPVRLEHIYVELMHHH
>NZ_AP018172.1|WP_096588989.1|3087248_3088751_+|Rieske-2Fe-2S-domain-containing-protein
MTTKNNLQGDIDNAIGQFHQQDEEIFQWTKQWYPVAVVDFLDPSRPHAVQLLGKDLVVWRDNLGKWSCFEDFCPHRLAPLSEGRVESDGTLLCAYHAWRFDAQGNCVSIPQSKDEQTASANCSNPKSCAVSYPTQERQGLLWVWAESGQTAQLESQLRTPRIIPELEDESLQVKHLFWNIRDLAYGWDFFMENVADPAHVPVSHHGIVGDRYKDAKYYDMPCIKQISTQEGFAFEITPTAPTIKQAIHDFQPPCHMKIVSTSVDGGKLILALYATPTRPGWCRHIGCQVLVKNESGKIPKGLGIFGLPMPTWLGHVLSSLFLHQDLVFLHYQQKILAKRQNNRWLDAVYTPNPQDKMVITFRQWLEKKAGGSIPWAGGESSNLSAAELDKQKLFDVWTTHTQHCSVCQDALKNIKRLYVLAYGLAAIFLCVGVIIDARAIAVKAALASVNHLPIPLLTVLPPIGFWWAFAGATLFAVVGYLLKKLSRLFYVYEFEHAHND
>NZ_AP018172.1|WP_096588991.1|3088942_3089839_+|alpha/beta-hydrolase
MFSSFLPSQVNQIKDLEAIAVVASIETIALVTPLSQQPILTTYIHKGRGGTPILLLHGFDSSILEFRLLLPLLAAENETWAVDLLGFGFTQRQKEIQYSPDTIKIHLYEFWANLIKEPIVLVGASMGGATAIDFTLTYPEIVKSLVLINSLGYTGAPTFSKYLFPPFDFFAVEYLRQRHILAFNIGSTLANLDPKILSAIQCAMLHQEMPGWYDAMISYVKTGGYTNLANRIAQVDKPTLILWGENDDMLASGDAEKFQKDIANSQLIKLKNCGHAPQIEQPQITSQHILQFLQYGDF
>NZ_AP018172.1|WP_096588993.1|3090273_3090696_-|DUF3011-domain-containing-protein
MITRFPAIAATLASLSLGTLLSIASPASAQQQVITCESHDGQPHSCSISTRGRVRGVRLIKQLSDTSCRNNWGYNRNRIWVRNGCRAQFVVRDRRNNRNDRYDRNDRYDDRYDRNDRYNDRYDRNDRYDDRYDRNDRYDR
>NZ_AP018172.1|WP_096588995.1|3090850_3091417_-|hypothetical-protein
MNQSIEKKQLDNIATWMLQIAETKLPTPLKGVFFMDGNPLPDTCITMYNLEWDTQNLSLVLPVYGPVQWTFHDSLPGFLLLVGAQLSRFTYKIQFEDATLKRSQIIPFAFGLQIPQWLANFTMTQDENSQNGETWQRQNVWLGFITGFGDYTLRKVVDEDGRYTPAFNDMLAKAPNECLVIVSNSKDK
>NZ_AP018172.1|WP_096588997.1|3091440_3092790_-|cytochrome-P450
MELKNKVLKAHRRQIRFSRILAKVGYNTAIGKLLRLGLYYMDGLTMLRAWRDFLYIRKDNIGDKFFAVDQAIMHSSHAQVRELMQVEPQVRGNDLGIIRILAPSYMLNNPLSLGMNGNEHTGIRAVFLQALPNPTEQAEFLGQLVNKSLSKAAIQGQLHIGNDLPRMMVAILHELVFQISLSEEEITASAAYIKGLALASLPNFISKYLLSFKTSPNIRHRQRLIERYKQSPRWSLYLATGAQYQLNAHQIANSLFDMIHIAGTAGTSALLGSVIGVLCLDNALRNDVISEVNAVWDGKDTPSGYALAQSTLLNKVILETARLYPPVRFVSQLSTERGEVEIGTQRCPFQRGTRLLGSIFTANRDANRYKNPDNFDLTRDFSDILSWNGEGHERVCPGRALSIGLIQMFCLYLFKNYQWNSFTEVKWDFEKVTAVTPNNLVLQGFASKR
>NZ_AP018172.1|WP_096588999.1|3092883_3094773_-|lipoxygenase
MTASPQNNSIIPVIASLEVARQEYQYNYTHIPPIAMVDELPTRERFSTNWYFLLAQQLRNLFVNTLITNRGNRGSKSIRDDVKMFILEAILKGAIPFNVSIVARVLQIIPQFLVKGISKDFHELDDLLFSILKENGLVILRDALNRVIELLYEGHPTGHVASLNDYERLFPVIEVPKIGKTFQEDRVFAYMRVAGYNPVMIQRVTSLSDRFPVTDEHYQAVMGTDDSLQAAGEEGRLYLTDYGIFEGALNGTYPQKQKYVYAPLALFALPKGSDPSRLLRPVAIQCGQTPGPDYPIITPKSGKYAWLFAKTIVQIADANFHEPVTHLARTHLFVGAFVMATQRQLPANHPLGILLRAHFEGTLAINDAAQRILIARGGGVDRLLSSTIDNSRVLAVRGLQSYGFNSAMLRKQFQQRGVDDPKLLPVYPYRDDALLVWDAIHGWVADYLNLYYATDNDIQNDAALQKWATEVQAYDGGRISDFGEDGRIQTREYLIDAATLIIFTASAQHAAVNFPQKDLMGYAAALPLAGYLPASTLKGDVTEQDYLNLLSPLDQAQRQYNLLGLLGAVYYNRLGEYPEGYFSDRRVQPLLQTFQTNLQQVEHTINQRNLNRPAYEYLLPSKIPQSINI
>NZ_AP018172.1|WP_096589001.1|3095116_3095500_+|Crp/Fnr-family-transcriptional-regulator
MLNPVQTLAIFQKQPDPKVFSAGQVIFQAGEPGDCMYGVIEGEVDILVDGKVVETIASGEVFAIGALVGVKNRTYTAIAKTDCQLAFLDEQRFLFAVQETPMFALQVMKNYSERLTRVEQQLSSLTV
>NZ_AP018172.1|WP_096589003.1|3095649_3096552_-|class-I-SAM-dependent-methyltransferase
MTQLAKSGSSLSEFQLRDGIYFPKNYEQLNSTEHKQKWDAIGKTYYGSQKIEQVPETSPIKQDYTLLGGRPGGTWNKFPMNKSVDSILEIGCGYGRAPLHLSIEKNLRCQKYFAIDISESLLRRLIRVKQEYDFFPGAQFNIICNSAEILPLEDNSVDLVISNCVFMHIPDLQLRNLLSEIFRVLKPGGSFVFNHSFHNKACPSHIIHNFIRSINIFSKNPIYLKQYSAVEIQEMLNAAGIKTKCPQYIVEPTTEYAILPETIKGIPLPFAKAINRSLKPADAWKETLAYGFSAYSDPLE
>NZ_AP018172.1|WP_096589005.1|3096864_3098373_+|FAD-dependent-oxidoreductase
MNEGSQQRVVVVGAGWAGLGATYHLAKQGYDVTLLEAGPYPGGLVAGWKTSAGRSVEAGIHGFWYPYRNIFALIHELGINPFTSWTRSAQYSPAGLEVESPIFQELPRLPSPLGTFLYTQFQRLPLIDRLSALPLLYSVVDFDNSHDAWRRYDFVTARELFKDFGVSARLYKEAFEPMLLVGLFAPGEQCSAAATLGMLYFFILAHQSDFDVVWCRGTVGEKIFRPWVERIEKAGAKVLSKRRVTDLIVDDNNRATGVVCDNEVFDADAVIFAVGVTGMKKIVANSPSLQSREEFRNINNLGAIDVLATRLWFDRKINIPRPSNACFGFDATTGWTFFDLNTLHDEYNNEPGTVIEADFYHANQFLNLSDEDIVAIVQRYLATCVPEFRDAKVIDSSVIRLPNAVTHFAPGSYRHMLPAKTSLANVFMSGDWIINRHGSWSQEKAYVTGLEAANLVVSYLGKGQRSQILPVEADEAHIQVARSLNQTVRQLTKSILPEFWLP
>NZ_AP018172.1|WP_096589006.1|3098580_3099996_+|HAMP-domain-containing-histidine-kinase
MYEWILPSLREILAESQPTAAESSPAKAEWQWRISLAATEQLLISTLANAASDANQGLVLAAPAPLFGQPTLTQNLQTVTFTAKPFNPLALMPFEMPIPLEMAEEIAPHESVLPLLPADPLGTEQFCLVFTDKFSLVLVLAEQNSGQKTFLFSFEPEIVQQAWRALGARVMLTNPDFFADLDASVQKFAPVAPDYRTVMQFSQLLLQEFAPEPDKENVPASPPVAVATSASSRPDVELLQAFAHEVRTPLTTIRTMTRLLLKRRDLPANVISRLEVIDHECTEQIDRMELLFKAAELETSNSAKPAHTQLTPMSLDRVLQQSIPRWQQAANRRNLTLDVVLPQQLPTVVSNPTMLDRVLTNLIENFTRSLPAGSHIQVQVIPAGDQLKLQLSPQPQCTDTSKATPATTPPIRKALGQLLMFQPETGTISLNISATKHLFQAIGGKLIVRQRPQHGEVMTIFLPLEVSTKQW

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Crispr_ID: NZ_AP018172_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_9

3739789-3739891

Orphan

Consensus_repeat	Method
CAGTTTTAAAGAATTATTGTCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018172_9

>merge|NZ_AP018172|9|3739789-3739891|CRISPRCasFinder
CAGTTTTAAAGAATTATTGTCCAATTTGATGTAGTTAGAGGACATAAGTTACGTAATCTCCTGCCTTTCAGCCATCAATCCAGTTTTAAAGAATTATTGTCCA

>NZ_AP018172|9|8|3739789-3739891|CRISPRCasFinder
CAGTTTTAAAGAATTATTGTCCA	ATTTGATGTAGTTAGAGGACATAAGTTACGTAATCTCCTGCCTTTCAGCCATCAATC
CAGTTTTAAAGAATTATTGTCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096589553.1\|3735580_3736462_-\|DUF4343-domain-containing-protein	unknown	unknown	gnl\|CDD\|372976
NZ_AP018172.1\|WP_096589560.1\|3744685_3746422_-\|mycodextranase	unknown	unknown	gnl\|CDD\|271156
NZ_AP018172.1\|WP_096589554.1\|3736562_3737744_-\|RtcB-family-protein	unknown	unknown	gnl\|CDD\|376465
NZ_AP018172.1\|WP_096589556.1\|3738932_3739658_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NZ_AP018172.1\|WP_096589550.1\|3731485_3731674_-\|DUF4089-domain-containing-protein	unknown	unknown	gnl\|CDD\|372560
NZ_AP018172.1\|WP_096589563.1\|3751502_3751886_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587106.1\|3734044_3735421_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP018172.1\|WP_096589561.1\|3746472_3747945_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371693
NZ_AP018172.1\|WP_096589557.1\|3742522_3742855_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|225408
NZ_AP018172.1\|WP_096589564.1\|3752000_3752396_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096586464.1\|3741238_3742252_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP018172.1\|WP_096589555.1\|3738045_3738936_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_AP018172.1\|WP_096589552.1\|3732316_3733834_-\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|215497
NZ_AP018172.1\|WP_096589549.1\|3730115_3731489_-\|AtzE-family-amidohydrolase	unknown	unknown	gnl\|CDD\|236409
NZ_AP018172.1\|WP_096589559.1\|3743990_3744539_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270620
NZ_AP018172.1\|WP_096589565.1\|3752520_3753558_-\|DUF1838-domain-containing-protein	unknown	unknown	gnl\|CDD\|378086
NZ_AP018172.1\|WP_096589558.1\|3743137_3743968_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|381595
NZ_AP018172.1\|WP_096589562.1\|3750109_3751060_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|133428
NZ_AP018172.1\|WP_096589551.1\|3731711_3732062_-\|DUF952-domain-containing-protein	unknown	unknown	gnl\|CDD\|226033
NZ_AP018172.1\|WP_096589548.1\|3729788_3730091_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096589553.1\|3735580_3736462_-\|DUF4343-domain-containing-protein	gnl\|CDD\|372976	pfam14243, DUF4343, Domain of unknown function (DUF4343). This domain family is found in bacteria, eukaryotes and viruses, and is typically between 127 and 142 amino acids in length.	2.93662e-17
NZ_AP018172.1\|WP_096589560.1\|3744685_3746422_-\|mycodextranase	gnl\|CDD\|271156	cd14490, CBM6-CBM35-CBM36_like_1, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	1.0583e-64
NZ_AP018172.1\|WP_096589554.1\|3736562_3737744_-\|RtcB-family-protein	gnl\|CDD\|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	0
NZ_AP018172.1\|WP_096589556.1\|3738932_3739658_+\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	1.24884e-49
NZ_AP018172.1\|WP_096589550.1\|3731485_3731674_-\|DUF4089-domain-containing-protein	gnl\|CDD\|372560	pfam13318, DUF4089, Protein of unknown function (DUF4089). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	3.72235e-20
NZ_AP018172.1\|WP_096587106.1\|3734044_3735421_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	3.92974e-08
NZ_AP018172.1\|WP_096589561.1\|3746472_3747945_-\|hypothetical-protein	gnl\|CDD\|371693	pfam11721, Malectin, Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.	5.92284e-21
NZ_AP018172.1\|WP_096589557.1\|3742522_3742855_+\|DUF559-domain-containing-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.000361437
NZ_AP018172.1\|WP_096586464.1\|3741238_3742252_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.09045e-05
NZ_AP018172.1\|WP_096589555.1\|3738045_3738936_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.31199e-29
NZ_AP018172.1\|WP_096589552.1\|3732316_3733834_-\|redoxin-domain-containing-protein	gnl\|CDD\|215497	PLN02919, PLN02919, haloacid dehalogenase-like hydrolase family protein.	2.18583e-172
NZ_AP018172.1\|WP_096589549.1\|3730115_3731489_-\|AtzE-family-amidohydrolase	gnl\|CDD\|236409	PRK09201, PRK09201, AtzE family amidohydrolase.	0
NZ_AP018172.1\|WP_096589559.1\|3743990_3744539_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	5.4803e-14
NZ_AP018172.1\|WP_096589565.1\|3752520_3753558_-\|DUF1838-domain-containing-protein	gnl\|CDD\|378086	pfam08894, DUF1838, Protein of unknown function (DUF1838). This family of proteins are functionally uncharacterized.	8.40173e-105
NZ_AP018172.1\|WP_096589558.1\|3743137_3743968_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|381595	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Glycoside hydrolase family 19 chitinases are found primarily in plants (classes I, III, and IV), but some are found in bacteria. Class I and II chitinases are similar in their catalytic domains. Class I chitinases have an N-terminal cysteine-rich, chitin-binding domain which is separated from the catalytic domain by a proline and glycine-rich hinge region. Class II chitinases lack both the chitin-binding domain and the hinge region. Class IV chitinases are similar to class I chitinases, but they are smaller in size due to certain deletions. Despite lacking any significant sequence homology with lysozymes, structural analysis reveals that family 19 chitinases, together with family 46 chitosanases, are similar to several lysozymes including those from T4-phage and from goose. The structures reveal that the different enzyme groups arose from a common ancestor glycohydrolase antecedent to the prokaryotic/eukaryotic divergence.	5.80408e-89
NZ_AP018172.1\|WP_096589562.1\|3750109_3751060_-\|L-lactate-dehydrogenase	gnl\|CDD\|133428	cd05292, LDH_2, A subgroup of L-lactate dehydrogenases. L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed predominantly of bacterial LDHs and a few fungal LDHs. Bacterial LDHs may be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	2.63351e-106
NZ_AP018172.1\|WP_096589551.1\|3731711_3732062_-\|DUF952-domain-containing-protein	gnl\|CDD\|226033	COG3502, COG3502, Uncharacterized protein conserved in bacteria [Function unknown].	1.48377e-44

>NZ_AP018172.1|WP_096589556.1|3738932_3739658_+|HAD-family-phosphatase
MSLKAVLFDFNGVIINDEQIHLRLIDEILIEENLQPQREKERQASLGRSDRACFQELLHNRGRVVSEEYLTQLLNRKAQAYVLELEKLEKLPLYSGLDDLIFQVRSRNLTIGLVSGAIRKEIDLVLERANLAEHFSVIVAGDDITTSKPKPDGYLLAVERLNQKYPDLNLQPQECLAIEDTPAGIQAAKRAQMQVVGVANTYPFHMLQRCCNWTVDYLTDLELERVQEVYTQKELKSATNE
>NZ_AP018172.1|WP_096589555.1|3738045_3738936_+|methyltransferase-domain-containing-protein
MAIPLNPFWERFLSPVVRFLIDEEGLERYALSIDWNKQSDRFQRADVAIPSYYSSYKFRGMEGGYLNPKVVVSYDPIIQYLLPPNESLVRQAVIDAIKVQPRRILDLGCGTGSNTLMLKQAFPQAEVIGLDLSAYMLVMAEQKATTAGLDIAWRHGNAEKTAFPDASFDLVTATLLFREIPTAVSQAILQECFRLLVVGGQVLILDINQKALRQLEWLKDVIEEPYLREYAALNLNESISKAGFEALPTQDVWWMHQLSSGVKPLSNRQQVRQYVSKSIDSSDLEELGSPVFGIRA
>NZ_AP018172.1|WP_096589554.1|3736562_3737744_-|RtcB-family-protein
MPYEKLEITTPTPVLSWANHELGPEETKMAKNVASLPFVFKHVALMPDVHLGKGALVGSVLATKEAIIPAAVGVDVGCGMCAIKMPFTGEQLEGKLKKIRLDIEAAIPTGFNENKEVEKSVSNWQRWNDFKDLHRGVQNLESKAMKQMGSLGGGNHFIEICLDTENQVWLMLHSGSRNIGNNLAQCHINTAKELAKMAGNNLPDPDLAHFVAGTPEFEAYWNDLQWAQDYARFNRDVMMARFKHIVEKHLAGGKSTKPLLQVNCHHNYAEKEVHFGEDVYVTRKGAVRAQTEDYGIIPGSMGAKSFIVKGKGNAHSFCSCSHGAGRLLSRNKAKNVYTLDDLIEQTKGVECRKDEGVLDEIPGAYKPIDRVMENQADLVEVVATLKQVLCVKG
>NZ_AP018172.1|WP_096589553.1|3735580_3736462_-|DUF4343-domain-containing-protein
MIVLSEATEQIEASASASENKLMTEAAQILGFKVYHIPRDFQRCGTAENALWHIPEYPEETAGIWIGYIPELERYQAIYQAALAKGVKLLNTPLEHQTALEFDLFYPHLQGLTPDSVIITSTQECIKAGELLGFPVFIKGAVQSRKQQGWESCVANNQEELIKLTEWLLKLKYGSRGRVIVRKLVKLRHQRLAPNGFPMGREFRCFIYNHQILKYRYYWDSKDDLSKLSPQEEKQVLNLALIASKCLKVPYVAIDIGQLESGEWIVIETADAQFAGICQIPPLELWNKLKDIS
>NZ_AP018172.1|WP_096587106.1|3734044_3735421_-|transposase
MLSAIFEQFVQESPISVMARGLMERVFAPEIMDKLFETHAKVQYQQDLLFSSQVDLMSLVVCGIQKSVHAAYKARAANLIVSSTALYKKLSGVELGVSQALVRQTASQLQLLIQKMAGEQPNPLPGYQHRIVDGTCLGATDHRLDAIRLFAAKALPGKAIVVSDPLSKLVIDIFPCVDAHAQERSLFDDVLLSVKANEVWNGDRNFCTAKFLFRIANQQAFFVVRQHGSLGYQQLSQLKAVGHTDTGNLFEQEIEINYDGNLLKSRRILLKLFKPTRDKEWEIAILTNLPSHDADAAKIAELYRNRWSLETLFQTVTENFHGEIQTLAYPKAALFSFSMALTTYNILATLKAALGSVHGVGKIDASLSDFYLVDEITGTYRGMMIAIPAVHWQAFETFSLEQMVLVLQDLAARVELKCFLKAIRGVKKKREPLIVDSKHRHVSTARLLDTHQNTQNKS
>NZ_AP018172.1|WP_096589552.1|3732316_3733834_-|redoxin-domain-containing-protein
MIPRVRAPELPQNSPWFNTDKPLSIKQLKGRVIILDFWTYCCINCLHIIPDLKYLEQKYQDSLTVIGVHSAKFDNEKETENIRQAILRYDIEHPVVVDSGFRVWQEYAVRAWPTLMIIDPEGYVIGYVAGEGHRDTLDELIEKLIQEHREKGTINFQELSLNLEKQRQPLITPLAFPGKVLATPAGLFIADSGHHRLVMSSFAREVMHVIGTGKSGLVDGNFNEAQFSAPQGMAFDADKQILYVADTENHALRRVDLQRQVVETITGTGEQSRNIRPHGGAGLETALNSPWDLVKVGNTLFIAMAGSHQIWEMDLETGVIKTYAGMGAEACIDGSLSESAFAQPSGISSNGEELYIADSEVSSIRGVGIVEPRLVRTVCGSGDLFGFGDVDGQSENVRLQHCLGVEYSQNYLWVADTYNHKIKLVSPSTGNCQTILGDGVMGLQDGQGKNTRFFEPSGLSVMGSNLYIADTNNHVIRCVDLNSFEVTTLKFKGLCAPDVCVPSNL
>NZ_AP018172.1|WP_096589551.1|3731711_3732062_-|DUF952-domain-containing-protein
MKNILHITQAEQWEQAKINGNYRADSLDTEGFIHCSELSQIVKVANSFFRNQKGLVLLFINADKIKAEIRYEEAEIGELFPHIYGELNIDAVFQVIDFKSGEDGLFELPLEVVNLD
>NZ_AP018172.1|WP_096589550.1|3731485_3731674_-|DUF4089-domain-containing-protein
MESQGFDVGEYVDRMALLVDLQLRDEYRDGVVANFERIKAIALLVNEFPIPEDIEVAPIFEP
>NZ_AP018172.1|WP_096589549.1|3730115_3731489_-|AtzE-family-amidohydrolase
MNDAVSIAAAVREGKVSAVEVTQAALAKIAARDNELNSFTAVIAETALADAARIDKEIAQGNHPGVLAGVPFAAKNLYDIAGLTTLAGAKINAENPPATQDATAVAKLKQAGAVLVGALNMDEYAYGFVTENAHYGATHNPHDLKRVAGGSSGGSAAAVAAGLVPLTLGSDTNGSIRVPAAFCGIFGLKPTYGRLSRAGVALFSSSFDHVGPFARSVRDIATAFDILQGEDDRDPVCTKRPPELCVPQLNRDISGIRIAIADDYFMKGAEPEALAAVERVARALDVNEYVTIPEAHRARAAAFVITASEGANLHLDKLRSRPQDFDPATRDRFLAGALIPSQWYLQAQRFRRWYRDRVREIFQNVDIILAPTTPIPAPLIGQQTTIVDGEEIIIRPHLGLFTQPLSFIGLPVLSVPIQLPKALPLGVQLIAAPYNEALILKVASVLEAQGIVSAPIA
>NZ_AP018172.1|WP_096589548.1|3729788_3730091_+|hypothetical-protein
MKVKFSQSGGYAGLIRGCELDTDSLPADEAAKLKSLVEQSGILHAQSKSTPQARDLLNYKITIETNEGAPTVSFDDLSLPENAQPLLKYLQGCAKPMPLR
>NZ_AP018172.1|WP_096586464.1|3741238_3742252_-|transposase
MRFTKLNYCQYLLSSQINYTITNLAEHLESISHDAINYYLKTEKLTPRLLWDNVKEVVESDENGYIIFDDSVLDKKYSEEIEIVRRQYSGNEHGVLKGIGVVSCVYVNPTLQRFWVIDYRIFNPDVDGKTKIDHVKDMLQNLVYHKLLPFDTVLMDTWYAVHSLMLYIDSLDKIYYCPLKNNRLVDDTFGQEKYKRIELLEWNQEELDCGKIIKIKGFPANKKVKLFRVTVSTNRTDYVATNDLSQSSTDVVQQVCKIRWKIEEFHREIKQLTGIESCQCRKARLQRNHIACAMLVWVRLKNLAYRTGKTIYQIKHNLLSNYLIQQLKRPSIFMCLV
>NZ_AP018172.1|WP_096589557.1|3742522_3742855_+|DUF559-domain-containing-protein
MRFRSRTEIKVAQVLEKRGLMYLPNSLMRLGRYHKSFEPDFLVCCPTAKGFKWAILEIDGYWHLPQKRAKEHERERLFEHSGVRVHRFDAELCENEPEAVVSELIELMTQ
>NZ_AP018172.1|WP_096589558.1|3743137_3743968_-|LysM-peptidoglycan-binding-domain-containing-protein
MSCTLGNSYTIKSGDTLSIIAQQQLGDSNRWREILKPDGTPFTDADASNLQVGQEICIPNGSVTPPAPPPTPPDNSFAGIVSRQTFEALFPNRNGFYSYDGLVAATQKYPSFCNEGSNEQCRREAAAFLANVTQETGFLQYIEELNTAVWGNYCDPTTYPCVQGKTYHGRGPIQLSWNYNYAVCGAALGIDLLNNPDLVSTDSAISFMTALWFWMTSCHDAIRNSGFGMTISIINGGIECGPNASPEGRQQAQNRINFYLDFCQKLGVSPGENLSC
>NZ_AP018172.1|WP_096589559.1|3743990_3744539_-|LysM-peptidoglycan-binding-domain-containing-protein
MSCTLGNSYIIKSGDTLFTIAQQQLGDGERWREILKPDGIAFTDVDAANLQVGQEICIPGSTPFPPPPSGNQIALEARFYSMEETNCHLPASGIHGITLQAALAGQLQSQCQGQSVRRLQCAVDPNVIPLLTNFTLVLWDGKQVPAAALDIGTAIIGNKIDIFVDTVQEAINLGVQSVTAIL
>NZ_AP018172.1|WP_096589560.1|3744685_3746422_-|mycodextranase
MKFSSIDNVALATAGVITIPYDEIQAENADHNGTVIDGRNDRTYPGLANEAIERRAVKLDTVGQYVEFTVPRDANSIVVRYAIPDSADGAGLTTPIGLYINGEKRPDLILTSKYSWIYGTYPFNNNPGDIRPHHFYDEVNRLTPQMSAGDKVRLMVESNSTAPWYIIDLVDFEQVAPAYAMPEGYLSLTADFGADPSGVQDSTTAFQNALDASSSQRRGLWIAPGEYKISTWLQVRDNVTLKGAGIWHSKIHFVAQTGNNAGLMGPWNTGTSAQNVNFSDFAIWGEVTQRVDNDQLNGIGGAYSNSTFTNLWIEHNKCGMWLDGPFDKLTIKNVRIRNQQADGINFHRQVTNSTVTQSFFRNTGDDSLAMWNEGGGGFNTFSFNRVEIPVLANGIAIYGGESNAVTDNYVADQQAEGGGIHIGNRFPGIRPISGTTVIARNVIVRAGSQDYYNSWNFGTGALWFYALDTDMAGAILVEDNQIIDSNYEAIHFIGSSVTNVTFNRNQIIGAGTYAMEIRCAGGVTISNTTATGLGHGGILNCRTDFAIADGGGNGDWIAQTPVCPDPYPKPIYTPVATS
>NZ_AP018172.1|WP_096589561.1|3746472_3747945_-|hypothetical-protein
MVDSIRINAGGGAIGIYGADAYYSGGQSASSNVPVDSKGVYYPANQEVYQTERYGTFTYTFTGLVPNAIHTVKLHFNEHFWDSVGKRKFNAAINGSQVLWDYDIFSQAGGINKAIAEEFVVTSDARGQIVVNFTPGAADQPTVSGFEINQGTPPRNNMLLGCFPGYANINDIESWLGKKHAVQVMFTSWDSNNKEQAFTTMNQIWDSGSVPLVTWEAFTDDKNRYAPANIDALIANGSYDSYLNDWADSMKSFLAGSGGVYGDADDRRVYLRFAHEMNGDWYPWSASYKNSQNTPTDYINMWQHVWTVFKNKGIDSNHLQWLWTPMNTDVGSPLNKAESYWPGDAYVDWVGIDAYNWGTGPSWSNWTPPVALLDDMINRLTGYGKPIAIPEWGTTSDNYGSNNVGAKGQWIVEMFDYLSVKPQIKMLCYFNIDKETDWAIFGGARGDSTYTIGSTVQQVYSNYKARVGKDYIIPGNNSPQRITDDHFKGL
>NZ_AP018172.1|WP_096589562.1|3750109_3751060_-|L-lactate-dehydrogenase
MISKTSKIGIIGAGNVGADVANALVLLGKCVRVVLFDRTLSKAEGQAWDIEDSIPLLKEMEIIPTNQYEDLADSDIIIVTAGVQPKQGQTRLDTLSDNAEIIRLTIKELDRVAPNSIIIIVSNPVDVLTRIAIATSTRAENLILGSGTVLDTARLRYQLGKRLNVAKQDIHAYVIGEHGDSQFVVWSSAFIGGILLTEFPIPQEATLEQIQQEYAQLTRKRGHNIFERKGNTSYGISIVICQLVDTILRDEKQIFPVSVRANSNYGFGSEVVLGLPCIIGSTGIERQLLLSRNAHEQRLLEESANKLNEAYNFLFN
>NZ_AP018172.1|WP_096589563.1|3751502_3751886_-|hypothetical-protein
MKFTTLMKTSALLLALPISILANFSLRASADSTAGIILSTKCQGGYNINIWQNYTSRELLYRATSANGNLSLGKGTSRATEGVRVYKFRNGIYEYWVWDGTLDNPQSGTLEVYKNNRILMKQDCRKS
>NZ_AP018172.1|WP_096589564.1|3752000_3752396_-|hypothetical-protein
MNSHTPSTRDIIGPSPLIAIENEAPPKLIVDPPLPEPLAQGRVFIQYRTENLRVLPVFGKGALEVSPRIGHIHITVDDLPWHFVDSSGETVILVGLEPGAHKVLIELADPMHKVITSETVKFTLPDPKKSS
>NZ_AP018172.1|WP_096589565.1|3752520_3753558_-|DUF1838-domain-containing-protein
MRGLPPQASFPVMPKPRRFKSVNETFTFLQMNKNLTRIQGMRRKTKFLYFWATVVVTVLALKQTPGEAQTRSDTQTVDIQELVRTRCATDPRNTYLEWSGSVYAFVPQEQQRKLFSIIGMNVARCFQNQQGQWLLTSRELQYYLDPKTNQVLNRWQNPWTGEVVPVVHVANNPVQSNLGQGRFPVLAAGRNLILTLDVPLTYPNVLASDPKFQDYSPEPLYQAGEFFKFVVPEARVEQPNVPTVLNVSGTWNRIGPWLPWMKMKGKPGQLVYSASIRKLQRFEELSPLLQQEITSRVPVYRTAPTCYLAASSKTSWTYFREYFNNYLAGDQFPISETQSNQTCQQ

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Crispr_ID: NZ_AP018172_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_10

3740250-3740506

Orphan

Consensus_repeat	Method
CTTTCAACCCACCACCGAGCGNNNGGAGGGTTATTGAAA	CRT

3 spacers

The CRISPR arrays of NZ_AP018172_10

>merge|NZ_AP018172|10|3740250-3740506|CRT
CTTTCAACCCACGACTTACTGACTGGGGAGTTATTGAAACGCGTCATGCCTCCAAGGCGTATAAACACAAGAAAACTTTCAACCCACCACCGAGCAGGAGGGTTATTGAAATTTGACTTCAGCATGGGCACGAAGAAGATAAGAGTATGCTTTCAACCCACCACCGAGCGGGAGGGTTATTGAAACCTGGTCGGTTGCCAGCGCGGAGCATTTTTAGCAATCTTTCAACCCACCACCGAGCGGGAGGGTTATTGAAA

>NZ_AP018172|10|6|3740250-3740506|CRT
CTTTCAACCCACGACTTACTGACTGGGGAGTTATTG	AAACGCGTCATGCCTCCAAGGCGTATAAACACAAGAAAA
CTTTCAACCCACCACCGAGCAGGAGGGTTATTGAAA	TTTGACTTCAGCATGGGCACGAAGAAGATAAGAGTATG
CTTTCAACCCACCACCGAGCGGGAGGGTTATTGAAA	CCTGGTCGGTTGCCAGCGCGGAGCATTTTTAGCAAT
CTTTCAACCCACCACCGAGCGGGAGGGTTATTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096589553.1\|3735580_3736462_-\|DUF4343-domain-containing-protein	unknown	unknown	gnl\|CDD\|372976
NZ_AP018172.1\|WP_096589560.1\|3744685_3746422_-\|mycodextranase	unknown	unknown	gnl\|CDD\|271156
NZ_AP018172.1\|WP_096589554.1\|3736562_3737744_-\|RtcB-family-protein	unknown	unknown	gnl\|CDD\|376465
NZ_AP018172.1\|WP_096589556.1\|3738932_3739658_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NZ_AP018172.1\|WP_096589550.1\|3731485_3731674_-\|DUF4089-domain-containing-protein	unknown	unknown	gnl\|CDD\|372560
NZ_AP018172.1\|WP_096589563.1\|3751502_3751886_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096587106.1\|3734044_3735421_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP018172.1\|WP_096589561.1\|3746472_3747945_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371693
NZ_AP018172.1\|WP_096589557.1\|3742522_3742855_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|225408
NZ_AP018172.1\|WP_096589564.1\|3752000_3752396_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096586464.1\|3741238_3742252_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP018172.1\|WP_096589555.1\|3738045_3738936_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_AP018172.1\|WP_096589552.1\|3732316_3733834_-\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|215497
NZ_AP018172.1\|WP_096589549.1\|3730115_3731489_-\|AtzE-family-amidohydrolase	unknown	unknown	gnl\|CDD\|236409
NZ_AP018172.1\|WP_096589559.1\|3743990_3744539_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270620
NZ_AP018172.1\|WP_096589565.1\|3752520_3753558_-\|DUF1838-domain-containing-protein	unknown	unknown	gnl\|CDD\|378086
NZ_AP018172.1\|WP_096589558.1\|3743137_3743968_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|381595
NZ_AP018172.1\|WP_096589562.1\|3750109_3751060_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|133428
NZ_AP018172.1\|WP_096589551.1\|3731711_3732062_-\|DUF952-domain-containing-protein	unknown	unknown	gnl\|CDD\|226033
NZ_AP018172.1\|WP_096589548.1\|3729788_3730091_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096589553.1\|3735580_3736462_-\|DUF4343-domain-containing-protein	gnl\|CDD\|372976	pfam14243, DUF4343, Domain of unknown function (DUF4343). This domain family is found in bacteria, eukaryotes and viruses, and is typically between 127 and 142 amino acids in length.	2.93662e-17
NZ_AP018172.1\|WP_096589560.1\|3744685_3746422_-\|mycodextranase	gnl\|CDD\|271156	cd14490, CBM6-CBM35-CBM36_like_1, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	1.0583e-64
NZ_AP018172.1\|WP_096589554.1\|3736562_3737744_-\|RtcB-family-protein	gnl\|CDD\|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	0
NZ_AP018172.1\|WP_096589556.1\|3738932_3739658_+\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	1.24884e-49
NZ_AP018172.1\|WP_096589550.1\|3731485_3731674_-\|DUF4089-domain-containing-protein	gnl\|CDD\|372560	pfam13318, DUF4089, Protein of unknown function (DUF4089). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	3.72235e-20
NZ_AP018172.1\|WP_096587106.1\|3734044_3735421_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	3.92974e-08
NZ_AP018172.1\|WP_096589561.1\|3746472_3747945_-\|hypothetical-protein	gnl\|CDD\|371693	pfam11721, Malectin, Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.	5.92284e-21
NZ_AP018172.1\|WP_096589557.1\|3742522_3742855_+\|DUF559-domain-containing-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.000361437
NZ_AP018172.1\|WP_096586464.1\|3741238_3742252_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.09045e-05
NZ_AP018172.1\|WP_096589555.1\|3738045_3738936_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.31199e-29
NZ_AP018172.1\|WP_096589552.1\|3732316_3733834_-\|redoxin-domain-containing-protein	gnl\|CDD\|215497	PLN02919, PLN02919, haloacid dehalogenase-like hydrolase family protein.	2.18583e-172
NZ_AP018172.1\|WP_096589549.1\|3730115_3731489_-\|AtzE-family-amidohydrolase	gnl\|CDD\|236409	PRK09201, PRK09201, AtzE family amidohydrolase.	0
NZ_AP018172.1\|WP_096589559.1\|3743990_3744539_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	5.4803e-14
NZ_AP018172.1\|WP_096589565.1\|3752520_3753558_-\|DUF1838-domain-containing-protein	gnl\|CDD\|378086	pfam08894, DUF1838, Protein of unknown function (DUF1838). This family of proteins are functionally uncharacterized.	8.40173e-105
NZ_AP018172.1\|WP_096589558.1\|3743137_3743968_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|381595	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Glycoside hydrolase family 19 chitinases are found primarily in plants (classes I, III, and IV), but some are found in bacteria. Class I and II chitinases are similar in their catalytic domains. Class I chitinases have an N-terminal cysteine-rich, chitin-binding domain which is separated from the catalytic domain by a proline and glycine-rich hinge region. Class II chitinases lack both the chitin-binding domain and the hinge region. Class IV chitinases are similar to class I chitinases, but they are smaller in size due to certain deletions. Despite lacking any significant sequence homology with lysozymes, structural analysis reveals that family 19 chitinases, together with family 46 chitosanases, are similar to several lysozymes including those from T4-phage and from goose. The structures reveal that the different enzyme groups arose from a common ancestor glycohydrolase antecedent to the prokaryotic/eukaryotic divergence.	5.80408e-89
NZ_AP018172.1\|WP_096589562.1\|3750109_3751060_-\|L-lactate-dehydrogenase	gnl\|CDD\|133428	cd05292, LDH_2, A subgroup of L-lactate dehydrogenases. L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed predominantly of bacterial LDHs and a few fungal LDHs. Bacterial LDHs may be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	2.63351e-106
NZ_AP018172.1\|WP_096589551.1\|3731711_3732062_-\|DUF952-domain-containing-protein	gnl\|CDD\|226033	COG3502, COG3502, Uncharacterized protein conserved in bacteria [Function unknown].	1.48377e-44

>NZ_AP018172.1|WP_096589556.1|3738932_3739658_+|HAD-family-phosphatase
MSLKAVLFDFNGVIINDEQIHLRLIDEILIEENLQPQREKERQASLGRSDRACFQELLHNRGRVVSEEYLTQLLNRKAQAYVLELEKLEKLPLYSGLDDLIFQVRSRNLTIGLVSGAIRKEIDLVLERANLAEHFSVIVAGDDITTSKPKPDGYLLAVERLNQKYPDLNLQPQECLAIEDTPAGIQAAKRAQMQVVGVANTYPFHMLQRCCNWTVDYLTDLELERVQEVYTQKELKSATNE
>NZ_AP018172.1|WP_096589555.1|3738045_3738936_+|methyltransferase-domain-containing-protein
MAIPLNPFWERFLSPVVRFLIDEEGLERYALSIDWNKQSDRFQRADVAIPSYYSSYKFRGMEGGYLNPKVVVSYDPIIQYLLPPNESLVRQAVIDAIKVQPRRILDLGCGTGSNTLMLKQAFPQAEVIGLDLSAYMLVMAEQKATTAGLDIAWRHGNAEKTAFPDASFDLVTATLLFREIPTAVSQAILQECFRLLVVGGQVLILDINQKALRQLEWLKDVIEEPYLREYAALNLNESISKAGFEALPTQDVWWMHQLSSGVKPLSNRQQVRQYVSKSIDSSDLEELGSPVFGIRA
>NZ_AP018172.1|WP_096589554.1|3736562_3737744_-|RtcB-family-protein
MPYEKLEITTPTPVLSWANHELGPEETKMAKNVASLPFVFKHVALMPDVHLGKGALVGSVLATKEAIIPAAVGVDVGCGMCAIKMPFTGEQLEGKLKKIRLDIEAAIPTGFNENKEVEKSVSNWQRWNDFKDLHRGVQNLESKAMKQMGSLGGGNHFIEICLDTENQVWLMLHSGSRNIGNNLAQCHINTAKELAKMAGNNLPDPDLAHFVAGTPEFEAYWNDLQWAQDYARFNRDVMMARFKHIVEKHLAGGKSTKPLLQVNCHHNYAEKEVHFGEDVYVTRKGAVRAQTEDYGIIPGSMGAKSFIVKGKGNAHSFCSCSHGAGRLLSRNKAKNVYTLDDLIEQTKGVECRKDEGVLDEIPGAYKPIDRVMENQADLVEVVATLKQVLCVKG
>NZ_AP018172.1|WP_096589553.1|3735580_3736462_-|DUF4343-domain-containing-protein
MIVLSEATEQIEASASASENKLMTEAAQILGFKVYHIPRDFQRCGTAENALWHIPEYPEETAGIWIGYIPELERYQAIYQAALAKGVKLLNTPLEHQTALEFDLFYPHLQGLTPDSVIITSTQECIKAGELLGFPVFIKGAVQSRKQQGWESCVANNQEELIKLTEWLLKLKYGSRGRVIVRKLVKLRHQRLAPNGFPMGREFRCFIYNHQILKYRYYWDSKDDLSKLSPQEEKQVLNLALIASKCLKVPYVAIDIGQLESGEWIVIETADAQFAGICQIPPLELWNKLKDIS
>NZ_AP018172.1|WP_096587106.1|3734044_3735421_-|transposase
MLSAIFEQFVQESPISVMARGLMERVFAPEIMDKLFETHAKVQYQQDLLFSSQVDLMSLVVCGIQKSVHAAYKARAANLIVSSTALYKKLSGVELGVSQALVRQTASQLQLLIQKMAGEQPNPLPGYQHRIVDGTCLGATDHRLDAIRLFAAKALPGKAIVVSDPLSKLVIDIFPCVDAHAQERSLFDDVLLSVKANEVWNGDRNFCTAKFLFRIANQQAFFVVRQHGSLGYQQLSQLKAVGHTDTGNLFEQEIEINYDGNLLKSRRILLKLFKPTRDKEWEIAILTNLPSHDADAAKIAELYRNRWSLETLFQTVTENFHGEIQTLAYPKAALFSFSMALTTYNILATLKAALGSVHGVGKIDASLSDFYLVDEITGTYRGMMIAIPAVHWQAFETFSLEQMVLVLQDLAARVELKCFLKAIRGVKKKREPLIVDSKHRHVSTARLLDTHQNTQNKS
>NZ_AP018172.1|WP_096589552.1|3732316_3733834_-|redoxin-domain-containing-protein
MIPRVRAPELPQNSPWFNTDKPLSIKQLKGRVIILDFWTYCCINCLHIIPDLKYLEQKYQDSLTVIGVHSAKFDNEKETENIRQAILRYDIEHPVVVDSGFRVWQEYAVRAWPTLMIIDPEGYVIGYVAGEGHRDTLDELIEKLIQEHREKGTINFQELSLNLEKQRQPLITPLAFPGKVLATPAGLFIADSGHHRLVMSSFAREVMHVIGTGKSGLVDGNFNEAQFSAPQGMAFDADKQILYVADTENHALRRVDLQRQVVETITGTGEQSRNIRPHGGAGLETALNSPWDLVKVGNTLFIAMAGSHQIWEMDLETGVIKTYAGMGAEACIDGSLSESAFAQPSGISSNGEELYIADSEVSSIRGVGIVEPRLVRTVCGSGDLFGFGDVDGQSENVRLQHCLGVEYSQNYLWVADTYNHKIKLVSPSTGNCQTILGDGVMGLQDGQGKNTRFFEPSGLSVMGSNLYIADTNNHVIRCVDLNSFEVTTLKFKGLCAPDVCVPSNL
>NZ_AP018172.1|WP_096589551.1|3731711_3732062_-|DUF952-domain-containing-protein
MKNILHITQAEQWEQAKINGNYRADSLDTEGFIHCSELSQIVKVANSFFRNQKGLVLLFINADKIKAEIRYEEAEIGELFPHIYGELNIDAVFQVIDFKSGEDGLFELPLEVVNLD
>NZ_AP018172.1|WP_096589550.1|3731485_3731674_-|DUF4089-domain-containing-protein
MESQGFDVGEYVDRMALLVDLQLRDEYRDGVVANFERIKAIALLVNEFPIPEDIEVAPIFEP
>NZ_AP018172.1|WP_096589549.1|3730115_3731489_-|AtzE-family-amidohydrolase
MNDAVSIAAAVREGKVSAVEVTQAALAKIAARDNELNSFTAVIAETALADAARIDKEIAQGNHPGVLAGVPFAAKNLYDIAGLTTLAGAKINAENPPATQDATAVAKLKQAGAVLVGALNMDEYAYGFVTENAHYGATHNPHDLKRVAGGSSGGSAAAVAAGLVPLTLGSDTNGSIRVPAAFCGIFGLKPTYGRLSRAGVALFSSSFDHVGPFARSVRDIATAFDILQGEDDRDPVCTKRPPELCVPQLNRDISGIRIAIADDYFMKGAEPEALAAVERVARALDVNEYVTIPEAHRARAAAFVITASEGANLHLDKLRSRPQDFDPATRDRFLAGALIPSQWYLQAQRFRRWYRDRVREIFQNVDIILAPTTPIPAPLIGQQTTIVDGEEIIIRPHLGLFTQPLSFIGLPVLSVPIQLPKALPLGVQLIAAPYNEALILKVASVLEAQGIVSAPIA
>NZ_AP018172.1|WP_096589548.1|3729788_3730091_+|hypothetical-protein
MKVKFSQSGGYAGLIRGCELDTDSLPADEAAKLKSLVEQSGILHAQSKSTPQARDLLNYKITIETNEGAPTVSFDDLSLPENAQPLLKYLQGCAKPMPLR
>NZ_AP018172.1|WP_096586464.1|3741238_3742252_-|transposase
MRFTKLNYCQYLLSSQINYTITNLAEHLESISHDAINYYLKTEKLTPRLLWDNVKEVVESDENGYIIFDDSVLDKKYSEEIEIVRRQYSGNEHGVLKGIGVVSCVYVNPTLQRFWVIDYRIFNPDVDGKTKIDHVKDMLQNLVYHKLLPFDTVLMDTWYAVHSLMLYIDSLDKIYYCPLKNNRLVDDTFGQEKYKRIELLEWNQEELDCGKIIKIKGFPANKKVKLFRVTVSTNRTDYVATNDLSQSSTDVVQQVCKIRWKIEEFHREIKQLTGIESCQCRKARLQRNHIACAMLVWVRLKNLAYRTGKTIYQIKHNLLSNYLIQQLKRPSIFMCLV
>NZ_AP018172.1|WP_096589557.1|3742522_3742855_+|DUF559-domain-containing-protein
MRFRSRTEIKVAQVLEKRGLMYLPNSLMRLGRYHKSFEPDFLVCCPTAKGFKWAILEIDGYWHLPQKRAKEHERERLFEHSGVRVHRFDAELCENEPEAVVSELIELMTQ
>NZ_AP018172.1|WP_096589558.1|3743137_3743968_-|LysM-peptidoglycan-binding-domain-containing-protein
MSCTLGNSYTIKSGDTLSIIAQQQLGDSNRWREILKPDGTPFTDADASNLQVGQEICIPNGSVTPPAPPPTPPDNSFAGIVSRQTFEALFPNRNGFYSYDGLVAATQKYPSFCNEGSNEQCRREAAAFLANVTQETGFLQYIEELNTAVWGNYCDPTTYPCVQGKTYHGRGPIQLSWNYNYAVCGAALGIDLLNNPDLVSTDSAISFMTALWFWMTSCHDAIRNSGFGMTISIINGGIECGPNASPEGRQQAQNRINFYLDFCQKLGVSPGENLSC
>NZ_AP018172.1|WP_096589559.1|3743990_3744539_-|LysM-peptidoglycan-binding-domain-containing-protein
MSCTLGNSYIIKSGDTLFTIAQQQLGDGERWREILKPDGIAFTDVDAANLQVGQEICIPGSTPFPPPPSGNQIALEARFYSMEETNCHLPASGIHGITLQAALAGQLQSQCQGQSVRRLQCAVDPNVIPLLTNFTLVLWDGKQVPAAALDIGTAIIGNKIDIFVDTVQEAINLGVQSVTAIL
>NZ_AP018172.1|WP_096589560.1|3744685_3746422_-|mycodextranase
MKFSSIDNVALATAGVITIPYDEIQAENADHNGTVIDGRNDRTYPGLANEAIERRAVKLDTVGQYVEFTVPRDANSIVVRYAIPDSADGAGLTTPIGLYINGEKRPDLILTSKYSWIYGTYPFNNNPGDIRPHHFYDEVNRLTPQMSAGDKVRLMVESNSTAPWYIIDLVDFEQVAPAYAMPEGYLSLTADFGADPSGVQDSTTAFQNALDASSSQRRGLWIAPGEYKISTWLQVRDNVTLKGAGIWHSKIHFVAQTGNNAGLMGPWNTGTSAQNVNFSDFAIWGEVTQRVDNDQLNGIGGAYSNSTFTNLWIEHNKCGMWLDGPFDKLTIKNVRIRNQQADGINFHRQVTNSTVTQSFFRNTGDDSLAMWNEGGGGFNTFSFNRVEIPVLANGIAIYGGESNAVTDNYVADQQAEGGGIHIGNRFPGIRPISGTTVIARNVIVRAGSQDYYNSWNFGTGALWFYALDTDMAGAILVEDNQIIDSNYEAIHFIGSSVTNVTFNRNQIIGAGTYAMEIRCAGGVTISNTTATGLGHGGILNCRTDFAIADGGGNGDWIAQTPVCPDPYPKPIYTPVATS
>NZ_AP018172.1|WP_096589561.1|3746472_3747945_-|hypothetical-protein
MVDSIRINAGGGAIGIYGADAYYSGGQSASSNVPVDSKGVYYPANQEVYQTERYGTFTYTFTGLVPNAIHTVKLHFNEHFWDSVGKRKFNAAINGSQVLWDYDIFSQAGGINKAIAEEFVVTSDARGQIVVNFTPGAADQPTVSGFEINQGTPPRNNMLLGCFPGYANINDIESWLGKKHAVQVMFTSWDSNNKEQAFTTMNQIWDSGSVPLVTWEAFTDDKNRYAPANIDALIANGSYDSYLNDWADSMKSFLAGSGGVYGDADDRRVYLRFAHEMNGDWYPWSASYKNSQNTPTDYINMWQHVWTVFKNKGIDSNHLQWLWTPMNTDVGSPLNKAESYWPGDAYVDWVGIDAYNWGTGPSWSNWTPPVALLDDMINRLTGYGKPIAIPEWGTTSDNYGSNNVGAKGQWIVEMFDYLSVKPQIKMLCYFNIDKETDWAIFGGARGDSTYTIGSTVQQVYSNYKARVGKDYIIPGNNSPQRITDDHFKGL
>NZ_AP018172.1|WP_096589562.1|3750109_3751060_-|L-lactate-dehydrogenase
MISKTSKIGIIGAGNVGADVANALVLLGKCVRVVLFDRTLSKAEGQAWDIEDSIPLLKEMEIIPTNQYEDLADSDIIIVTAGVQPKQGQTRLDTLSDNAEIIRLTIKELDRVAPNSIIIIVSNPVDVLTRIAIATSTRAENLILGSGTVLDTARLRYQLGKRLNVAKQDIHAYVIGEHGDSQFVVWSSAFIGGILLTEFPIPQEATLEQIQQEYAQLTRKRGHNIFERKGNTSYGISIVICQLVDTILRDEKQIFPVSVRANSNYGFGSEVVLGLPCIIGSTGIERQLLLSRNAHEQRLLEESANKLNEAYNFLFN
>NZ_AP018172.1|WP_096589563.1|3751502_3751886_-|hypothetical-protein
MKFTTLMKTSALLLALPISILANFSLRASADSTAGIILSTKCQGGYNINIWQNYTSRELLYRATSANGNLSLGKGTSRATEGVRVYKFRNGIYEYWVWDGTLDNPQSGTLEVYKNNRILMKQDCRKS
>NZ_AP018172.1|WP_096589564.1|3752000_3752396_-|hypothetical-protein
MNSHTPSTRDIIGPSPLIAIENEAPPKLIVDPPLPEPLAQGRVFIQYRTENLRVLPVFGKGALEVSPRIGHIHITVDDLPWHFVDSSGETVILVGLEPGAHKVLIELADPMHKVITSETVKFTLPDPKKSS
>NZ_AP018172.1|WP_096589565.1|3752520_3753558_-|DUF1838-domain-containing-protein
MRGLPPQASFPVMPKPRRFKSVNETFTFLQMNKNLTRIQGMRRKTKFLYFWATVVVTVLALKQTPGEAQTRSDTQTVDIQELVRTRCATDPRNTYLEWSGSVYAFVPQEQQRKLFSIIGMNVARCFQNQQGQWLLTSRELQYYLDPKTNQVLNRWQNPWTGEVVPVVHVANNPVQSNLGQGRFPVLAAGRNLILTLDVPLTYPNVLASDPKFQDYSPEPLYQAGEFFKFVVPEARVEQPNVPTVLNVSGTWNRIGPWLPWMKMKGKPGQLVYSASIRKLQRFEELSPLLQQEITSRVPVYRTAPTCYLAASSKTSWTYFREYFNNYLAGDQFPISETQSNQTCQQ

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Crispr_ID: NZ_AP018172_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_11

3854048-3854449

Orphan

Consensus_repeat	Method
GTTTCCA---------TCCCCGTGAGGGGTAATGATTTGAAAAC	PILER-CR
GTTTTCAAANCATTACCCCTCACGGGGATGGAAAC	CRT

5 spacers

The CRISPR arrays of NZ_AP018172_11

>merge|NZ_AP018172|11|3854048-3854449|PILER-CR,CRT
GTTTTCAAATCATTACCCCTCACGGGGATGGAAACGTAAGTACTCGTAGTGTTGCCACCCCGAACATCAATAGTTTTCAAATCATTACCCCTCACGGGGATGGAAACTGATTTCAAACTTTCAATCAGATTTTCAAAAACATTTAGTTTTCAAATCATTACCCCTCACGGGGATGGAAACTTAAAACAAATCCAGATACAACTCCAACGACTTTAGAAGTTTTCAAATCATTACCCCTCACGGGGATGGAAACCTAAAGATGTTACTTGCTCTTTGAACAGCATAAGCAAGATTAGTTTTCAAAACATTACCCCTCACGGGGATGGAAACTTGAGTCATGTAATCAACAATTTCTGAGGTAGCAGAGGTTTTCAAAACATTACCCCTCACGGGGATGGAAAC

>NZ_AP018172|11|7|3854048-3854449|PILER-CR
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	GTAAGTACTCGTAGTGTTGCCACCCCGAACATCAATA
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	TGATTTCAAACTTTCAATCAGATTTTCAAAAACATTTA
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	TTAAAACAAATCCAGATACAACTCCAACGACTTTAGAA
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	CTAAAGATGTTACTTGCTCTTTGAACAGCATAAGCAAGATTA
GTTTTCAAAACATTACCCCTCACGGGGATGGAAAC	TTGAGTCATGTAATCAACAATTTCTGAGGTAGCAGAG
GTTTTCAAAACATTACCCCTCACGGGGATGGAAAC

>NZ_AP018172|11|7|3854048-3854449|CRT
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	GTAAGTACTCGTAGTGTTGCCACCCCGAACATCAATA
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	TGATTTCAAACTTTCAATCAGATTTTCAAAAACATTTA
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	TTAAAACAAATCCAGATACAACTCCAACGACTTTAGAA
GTTTTCAAATCATTACCCCTCACGGGGATGGAAAC	CTAAAGATGTTACTTGCTCTTTGAACAGCATAAGCAAGATTA
GTTTTCAAAACATTACCCCTCACGGGGATGGAAAC	TTGAGTCATGTAATCAACAATTTCTGAGGTAGCAGAG
GTTTTCAAAACATTACCCCTCACGGGGATGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096589652.1\|3853239_3853623_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096589659.1\|3860914_3861538_+\|chorismate-binding-protein	unknown	unknown	gnl\|CDD\|368789
NZ_AP018172.1\|WP_096589660.1\|3861515_3861878_+\|CpeR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_AP018172.1\|WP_096595276.1\|3859334_3860093_+\|photosystem-I-reaction-center-subunit-XII	unknown	unknown	gnl\|CDD\|366093
NZ_AP018172.1\|WP_096595275.1\|3856022_3856469_+\|DUF2656-domain-containing-protein	unknown	unknown	gnl\|CDD\|371268
NZ_AP018172.1\|WP_096589650.1\|3851627_3852809_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096589655.1\|3856501_3857206_+\|ankryin	unknown	unknown	gnl\|CDD\|222984
NZ_AP018172.1\|WP_096589648.1\|3847980_3850098_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|380161
NZ_AP018172.1\|WP_096589657.1\|3858484_3859234_+\|photosystem-I-reaction-center-subunit-XII	unknown	unknown	gnl\|CDD\|366093
NZ_AP018172.1\|WP_096589653.1\|3854672_3855032_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096589644.1\|3844060_3844801_-\|phycocyanobilin:ferredoxin-oxidoreductase	unknown	unknown	gnl\|CDD\|179478
NZ_AP018172.1\|WP_096589647.1\|3847596_3847971_-\|response-regulator	unknown	unknown	gnl\|CDD\|381104
NZ_AP018172.1\|WP_096589658.1\|3860190_3860721_+\|phycobiliprotein-lyase	unknown	unknown	gnl\|CDD\|381208
NZ_AP018172.1\|WP_096589656.1\|3857584_3858445_+\|photosystem-I-reaction-center-subunit-XII	unknown	unknown	gnl\|CDD\|366093
NZ_AP018172.1\|WP_096589654.1\|3855300_3855768_-\|Orange-carotenoid-protein	unknown	unknown	gnl\|CDD\|370323
NZ_AP018172.1\|WP_096589643.1\|3843300_3843882_+\|phycobilisome-protein	unknown	unknown	gnl\|CDD\|381268
NZ_AP018172.1\|WP_096589651.1\|3852958_3853216_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096589646.1\|3845644_3847588_-\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_AP018172.1\|WP_096589645.1\|3844889_3845534_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_AP018172.1\|WP_096589649.1\|3850562_3851600_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096589659.1\|3860914_3861538_+\|chorismate-binding-protein	gnl\|CDD\|368789	pfam06206, CpeT, CpeT/CpcT family (DUF1001). This family consists of proteins of proteins belonging to the CpeT/CpcT family. These proteins are around 200 amino acids in length. The proteins contain a conserved motif PYR in the amino terminal half of the protein that may be functionally important. The species distribution of the family is interesting. So far it is restricted to cyanobacteria, cryptomonads and plants. It has been shown that CpcT encodes a bilin lyase responsible for attachment of phycocyanobilin to the beta subunit of phycocyanin.	3.15431e-98
NZ_AP018172.1\|WP_096595275.1\|3856022_3856469_+\|DUF2656-domain-containing-protein	gnl\|CDD\|371268	pfam10847, DUF2656, Protein of unknown function (DUF2656). This bacterial family of proteins has no known function.	1.22139e-75
NZ_AP018172.1\|WP_096589658.1\|3860190_3860721_+\|phycobiliprotein-lyase	gnl\|CDD\|381208	cd19433, lipocalin_CpcS-CpeS, CpcS/CpeS phycobiliprotein lyase family. Phycobilin lyases covalently attach a chromophore to the Cys residue(s) of cyanobacterial phycobiliproteins. They include Synechococcus sp. PCC 7002 phycocyanobilin lyase CpcS which attaches a phycocyanobilin chromophore to C-phycocyanain beta subunit and to allophycocyanin alpha and beta subunits, Synechococcus sp. PCC 7002 phycocyanobilin lyase subunit CpcU which forms a heterodimer with CpcS-I to attach phycocyanobilin to beta-phycocyanin and to allophycocyanin subunits, and Prochlorococcus marinus phycoerythrobilin lyase CpeS which attaches 3Z-phycoerythrobilin to phycoerythrin. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.	1.85291e-88
NZ_AP018172.1\|WP_096589655.1\|3856501_3857206_+\|ankryin	gnl\|CDD\|222984	PHA03100, PHA03100, ankyrin repeat protein; Provisional.	6.821e-27
NZ_AP018172.1\|WP_096589648.1\|3847980_3850098_-\|PAS-domain-containing-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	5.89925e-56
NZ_AP018172.1\|WP_096589657.1\|3858484_3859234_+\|photosystem-I-reaction-center-subunit-XII	gnl\|CDD\|366093	pfam00427, PBS_linker_poly, Phycobilisome Linker polypeptide.	3.44261e-72
NZ_AP018172.1\|WP_096589644.1\|3844060_3844801_-\|phycocyanobilin:ferredoxin-oxidoreductase	gnl\|CDD\|179478	PRK02816, PRK02816, phycocyanobilin:ferredoxin oxidoreductase; Validated.	7.65478e-152
NZ_AP018172.1\|WP_096589647.1\|3847596_3847971_-\|response-regulator	gnl\|CDD\|381104	cd17552, REC_RR468-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains. Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.91372e-72
NZ_AP018172.1\|WP_096589656.1\|3857584_3858445_+\|photosystem-I-reaction-center-subunit-XII	gnl\|CDD\|366093	pfam00427, PBS_linker_poly, Phycobilisome Linker polypeptide.	4.08102e-77
NZ_AP018172.1\|WP_096589654.1\|3855300_3855768_-\|Orange-carotenoid-protein	gnl\|CDD\|370323	pfam09150, Carot_N, Orange carotenoid protein, N-terminal. Members of this family adopt an alpha-helical structure consisting of two four-helix bundles. They are predominantly found in prokaryotic orange carotenoid protein, and carotenoid binding proteins.	1.61608e-45
NZ_AP018172.1\|WP_096589643.1\|3843300_3843882_+\|phycobilisome-protein	gnl\|CDD\|381268	cd12130, Apl, Allophycocyanin-like globins. phycobilisomes (PBSs) are the main light-harvesting complex in cyanobacteria and red algae. In general, they consist of a central core and surrounding rods and function to harvest and channel light energy toward the photosynthetic reaction centers within the membrane. They are comprised of phycobiliproteins/chromophorylated proteins (PBPs) maintained together by linker polypeptides. PBPs have different numbers of chromophores, and the basic monomer component (alpha/beta heterodimers) can further oligomerize to ring-shaped trimers (heterohexamers) and hexamers (heterododecamers). Stacked PBP hexamers form both the core and the rods of the PBS; the core is mainly made up by allophycocyanin (APC) while the rods can be composed of the PBPs phycoerythrin (PE), phycocyanin (PC) and phycoerythrocyanin (PEC). This subfamily contains allophycocyanin-like proteins (Apls), which have conserved the residues critical for chromophore interactions, but may not maintain the proper alpha-beta subunit interactions and tertiary structure of phycobiliproteins. Indeed AplA isolated from Fremyella diplosiphon was not detected in phycobilisomes. As the genes encoding Apls cluster with light-responsive regulatory components, Apls may have photoresponsive regulatory role(s).	7.04234e-85
NZ_AP018172.1\|WP_096589646.1\|3845644_3847588_-\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.76507e-76
NZ_AP018172.1\|WP_096589645.1\|3844889_3845534_-\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.84033e-17
NZ_AP018172.1\|WP_096595276.1\|3859334_3860093_+\|photosystem-I-reaction-center-subunit-XII	gnl\|CDD\|366093	pfam00427, PBS_linker_poly, Phycobilisome Linker polypeptide.	8.29052e-76

>NZ_AP018172.1|WP_096589652.1|3853239_3853623_-|hypothetical-protein
MRLLFNKLSTLLNKAKTFFNKVNTLFNKPSTFFNKVSTLFNKPKTFFNKVNTFFNKVNTFFNKVNTFFNKVNTFFNKVNTFFNKVNTLLNKPSTLFNKINYFTVITELIIQFFWKKYLILVIFTDGR
>NZ_AP018172.1|WP_096589651.1|3852958_3853216_+|hypothetical-protein
MVRCSDESSNFDAMSDAELKRYFLSNRQDQAAFQAYLDRFSQRPKSLIASPSDPDFDAKIQAAIRQKLEASRSSQPANNTVEPTE
>NZ_AP018172.1|WP_096589650.1|3851627_3852809_+|hypothetical-protein
MEIIKNILITALDLATMIIAIVCTVAMLQTALMVLKKSLKVNGGKASVGITRCEITLLSASELKFINNSISLLMHEFREFSAKVNYDRIPETIHDRKAKEKFRQVCDQISEQMKRPRIPLNSSLYENLGELIAFLKRSADSKEPVAEVFLEYKLHLPVREPLSRKLWEGKVIDKEEYWKEKYRFFSLKEGTHSWLGIELTYNKKLLEAPITSKKFKEFLQCKIKALQQEIEKAIAIVDNQQRDLQVEIESYKRESANMIINIDVEAKAMAENQAKSVTYNQQGSKWGGGFAAEGGIQSGGQLFDLSSKQNLDEAAKEIQQLLEQLSTTYPTTTSTDQIIVAAKAVEEIENNPALKQRVIGALKAGGTEALKELIDHPAVNILLATIEGWQSPI
>NZ_AP018172.1|WP_096589649.1|3850562_3851600_+|hypothetical-protein
MQNSLEGAREPEKPAPGIIDRALQHYEQGKELADTHYKRRLEKAIAEFEELFAIVAFYHDPAKPLFFHRENILPDAYKYCGLAHLKLSYERLVDHPESHLKKSIENFLYASYYRSKTSRKDKQPTTKWEEIQSSCNDYIEKYKQGEARQESKAFFSLLISDGFNQLIEVNNTSTGKIKDAIMGFEIIDIESELGNFSQAILTFYARLYEYRGYSYKQVENFYAAKFDLERVCNIYRLIQRNTSETDDVISAIKKTIQELEQKIDDLKQKSERKLEDAKRRNAQIEVAQRFRSGFFRDFVKFFLYWMAVLCSFLKTIILFTVKILPMLATWIKELESQSQRANKEK
>NZ_AP018172.1|WP_096589648.1|3847980_3850098_-|PAS-domain-containing-protein
MSKNSSKQLKQSGAKKIKHQRRIHKRLIKTLFQNAHDAIALIDDRLCFVDMNTAACDLLGLPRKQLKGQAISTFITAEFARQPKSGNFPPAQSLMGELLVSSSAQIQKEVEYTLTPNVFPHCHLLQLRDISQRRESMQAELRQQKQRVELFSEVTLKIRQSLQLKEILHTTVTEVQRILKADRVLIYHVLPDGTGKTISEAVLPDYPALMDLEFPQEVFPQEYQQLYAQGRVRAIANVHDPAAGLADCLVEFVDQFQIKAKLIVPIVQNLNANSQNQLWGLLIAHQCDSVRHWVDFELELMQQLADQISIALSQAQLLERLEDVVAARTAELQEEINVRKQAEAALRESEEQLRLITNALPVLIAYVDDRQQYRFNNQAYQDWLGQSPQEIYGCHLHQVWGEDCYQRMQVHVKTALSGQAVNYENDIVLKDGSWRSVDVTYIPHLDDEKMVKGFFALSSDISDRKAIERMKDEFISIVSHELRTPLTSLHSALKILATGRLGSLSSEGQQMLGIADDSTERLVRLVNNVLDLQRIEFGKAILECQACSAANLTIQAAEAMQAMAQQQEVTLVKQPQDISVWADADYILQALTNLLSNAIKFSSPGGTVWLTVEQAPASTNLPPEVVFRVRDEGPGIPADQLERIFERFQQVDSSDSRKKGGTGLGLTICRKIIEQHNGRIWAESTPGCGSTFSFTLPTLDSANIS
>NZ_AP018172.1|WP_096589647.1|3847596_3847971_-|response-regulator
MDTKRILIIDDEETIQTVVQFGIRMAAGWEVFTASSGFEGIQTAQTQKPDAILLDVMMPDMDGIATFKELQSHSETEQIPVILLTAKAQTAEKRQFNDLGVSGVITKPFNSLDLPEQITRILHW
>NZ_AP018172.1|WP_096589646.1|3845644_3847588_-|response-regulator
MKILLVEDDDILIKVLTKNLTTHHYIVDVVKDGEMGWTYGSSFEYDLIVLDIMLPKLDGISLCKRFRTQGYTHPIMLLTAQDSITAKVQGLDAGADDYLVKPVDPIELIARIRALLRRGSNNPFPLLSWGDLLLNPSTCEVTYNGRPLNLTTMEYDLLELLLRDCQHVFSTEELLDRLWSSEEFPSEATVRSHIRRVRHKLVAAGAPHDFIATMHGRGYYLKAPSTEESTGLSTTSPENKSQSSANIAKSTETQSDFPQHLTPTDSQQQYLAFLNETWTTTKPKSLDQMSILLQTVTDLQTNQLTSQKQAQAHQVAHKLAGTLGIFGLTKTMHIARQLEYWLGGREPLQPKHAPLMKTLVTALQQDIDRTTLIQMSQIPNAQAPLLLIVSSDTEFNSSLVTVAASRGIRLEIVPEPDVAQALLTNESVLDDLGQDPDVILLRLPAIASELPSPQLSNFWETLQTFAQRYPDLPIVVMGDRGDLSDRLEAMRRGGKLFLAGPTPPEQAIDAVVNLLRGPEIPNKVMILDDDRDWLRTLPTLLKPWGFKVTTLADPQQFWTVLQAVTPDALVLDVNMPQINGFELCQILRSDPHWQRLPVLFLSVLTDSESTNQAFNVGADDYLCKPVKGVELANRILRRLQRVKAWAS
>NZ_AP018172.1|WP_096589645.1|3844889_3845534_-|Uma2-family-endonuclease
MVATALYAETRTLLKNISWQTFKIMLAEMGSERQSRLAYNNQIVEIMTPLMPHENSNRIIEGFIVVLLEECDREFKRSGSLTLTRDDLETGGEPDSSYYIDNELLVRDKENIDLAIDPPPDLVLEVEYSRPAIDKLRLYAALGIPEFWRYNGSVLRIYTLRDGQYLEVQTSPTFALVPVQEIPRFIQEARKNGENKTTRAFRAWVRQHLSAKQQ
>NZ_AP018172.1|WP_096589644.1|3844060_3844801_-|phycocyanobilin:ferredoxin-oxidoreductase
MLNSMQASLRNRQHPLIHRLADSIEEIWQQHLDLSPYSVPEGLGYVEGHLEGERLIIENHCYQTPQFRKLHLELAQVGNGLDILHCVMFPNPEYAIPIFGTDLVGGRGGISAAIADLSPISSDRTLPSSYYQKLSVLSRLEFSQPRALPEWGDIFSEFCLFVRPGDSQEEDKFLNRVREFLTIHCQIASQQQPLTSNLDISKVLAGQRNYCTKQQQNDKTRRVLEKSFGTEWADRYMTTMLFDYVA
>NZ_AP018172.1|WP_096589643.1|3843300_3843882_+|phycobilisome-protein
MTQPQLSEKVRELIQKSRIVSFATWQNTHPAEAIQLFQAADDGGRYLSDEDLQQIQQLVPANTALISVSQALRDRVPEIVDEARTQVLARFPNITQPGGGLYPPMRADACWRDFWHFLRCITYGIAGQHTDYTSTEGLHYMQLLYQELQVPLDAMVVGLEGIKTASLKRVEPEQQAIVAPYFDRLIEQLKQFR
>NZ_AP018172.1|WP_096589653.1|3854672_3855032_+|hypothetical-protein
MRYLRLTITDTLSFWDDYLSGYIFDPENSKTFTNWYRIPDKWLENGTLVPERREQLLEHLYGSNWRLGNEDGSKYVVLKIDEHELSDTETAQRLWVGTQNTCYAVSDDDTIESVNEEVM
>NZ_AP018172.1|WP_096589654.1|3855300_3855768_-|Orange-carotenoid-protein
MTAYTSQAAKHAETFKRLSVDDQLAVLWYAYRFICSESGMKQPNGTAPDNSDELFNKAKSLSQNEQLQLMRDLLKRTNTDIAREYNSLTNNTKLAFWYQLAQGMERSEIIQAPSDYQPSSEVKGLVSVLKPIGFEQQFVFLRDALLSDGGKPSVM
>NZ_AP018172.1|WP_096595275.1|3856022_3856469_+|DUF2656-domain-containing-protein
MLLSHNFDVSPETIPALSREEFAEVFRSGLSAYENLQCRLVNHPHWILEILFPANEFLPQQVGEICAKALAEKRRSQQLSAETIPEILVLGGIKTTPPTSDSPDALQPGNWGVDVVETHSGETFLQAIAWDATIAQKPADSVFKVELK
>NZ_AP018172.1|WP_096589655.1|3856501_3857206_+|ankryin
MPSLNEDLIRVIVKGDTSAVNSLLAQGADANTTGGVTAVGASNTALMWAATEGYLEIVELLLAHNADVNVKNPAGYTALMFAAEGDRRNIVSLLLDRGADIGDRNHYGETVLMTMARRGQTDIVQRLVQMGAEVNATNKIGDTALYLAADNGHTYTVKALIELGAQVNTANIGGWTPLMMAAARGDLETMTILLEHGADFRPKNRWGATALSEARNSFRSAQAVDLLIRAGATE
>NZ_AP018172.1|WP_096589656.1|3857584_3858445_+|photosystem-I-reaction-center-subunit-XII
MPFGPASRLGVSLFEETPPVEWVPGRSQEEAETIIRAVYRQVLGNAYVMESERLTVPESQFKRGELSVREFVRAVAKSELYRSRFFTSCARYRAIELNFRHLLGRPPLDLEEMRSHSTILDTQGFEAEIDSYLDSDEYQSTFGENIVPYIRGYKTEALQSMVQFTHTFQLVRGASSSSLKGDLSGKAPKLNSLVIQSTPTAVISPASAGATFSTPPTGARTRLGVDASAGGKVYRIEVTGYRAKTFNSISKFRRSNQVFLVPYDKLSQEYQRIHQQGGVIASITAV
>NZ_AP018172.1|WP_096589657.1|3858484_3859234_+|photosystem-I-reaction-center-subunit-XII
MASQTILELWPSSSLEEVQTIIRAVYKQVLGNPHVMESERLVTAESQLCDRSITVREFVRTVAKSDFYRTRYFSSCAPYRFVELNFLHLLGRAPQDQREVSEHIVRTVAEGYDAEIDSYIDSSEYQTAFGENVVPYYRGKSSNANPKQVGYNRIFALDRGPAQVDSAVKSAQLVYAVATNSANAIKASSANVIGSGTEKRFKIVVTGSKFDSPRRISTTEYIVPASKMTPQIQRINRTSGKIISITEIA
>NZ_AP018172.1|WP_096595276.1|3859334_3860093_+|photosystem-I-reaction-center-subunit-XII
MALWIEAESVELRPNATEDDLQAAIAAVYRQVLGNAHIFESQRLTSAESQLRHGDITVAGFVRAVAQSDLYRSLFFETSSPYRFIELNFKHLLGRAPQDQAEIAAHVQIYNTQGYAAEINSYIDSDEYIRSFGDHIVPYARGNRTQVGVKNVTFNRTFSLMRGFAANDLGKSAKLISDIGANLATKIVTPSGGSGAASNTGKRFRISVSRANFGVRVTKSVATFEVGYNQLAQKIQSIQKTGGKIISIAEIA
>NZ_AP018172.1|WP_096589658.1|3860190_3860721_+|phycobiliprotein-lyase
MDITKFVANSIGHWRSQRSAHHLAFGHFEAVQSEIDIIALPDDDPEVIELCKTYNIDPQTAVSPFRMSWEGQSDWDDNEIKGTCVLVPIPDPTHPNRGKLLRDRGYAETMAAAGDYHLTEDGTFVLVTAYDRAAAEEKIWFANPNVRCRVSLIKTSAGSGVVTASFSSEIRQSVRS
>NZ_AP018172.1|WP_096589659.1|3860914_3861538_+|chorismate-binding-protein
MTSSLPNICQTGSHNLITLARWMAGDFSNYQQAFKNPKEYAHIHVFFRPLPFEFFSGIGLYSEQVYDYDLWRPYRQGVHRLVDRGDEIYIENYSLKNALLYAGAARELSILRTITPDCIERRYHCSMIFKREGDRFIGGVEPGNLCLIEKNGCQTYLHSYVEITQNTWVSLDRGLDVNTHEQVWGSAFGPLQFEKRESFAHEVPNIL
>NZ_AP018172.1|WP_096589660.1|3861515_3861878_+|CpeR-family-transcriptional-regulator
MKSQTSYDLSLPNLAVKANMLPPEAQKKMQCWIRSRHLICSGNFFVFETVDYSAIERFSQCVGALGGTVISVDPIDKIWMGAHRQVILYQARASLHTPCHNLKQYWLKYGGFRSRFDEQV

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Crispr_ID: NZ_AP018172_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_12

4587718-4587919

Orphan

Consensus_repeat	Method
GATTTACTGAAAGGAGAAAGTATTCAGGCATTTGAAGAAAGTGATATGCCTTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018172_12

>merge|NZ_AP018172|12|4587718-4587919|CRISPRCasFinder
GATTTACTGAAACGAGAAAGTATTCAGGCATTTGAAGAAAGCAAGATACCTTTTTGCTTGCCTAAAAGACCATAATAAGTGCGTGATTTACTAAAATGAGAAAGTCATCTGCCTTTTTGCTTGCCTAAAATACCATAATGAGTGCGTGATTTACTGAAAGGAGAAAGTATTCAGGCATTTGAAGAAAGTGATATGCCTTTTT

>NZ_AP018172|12|9|4587718-4587919|CRISPRCasFinder
GATTTACTGAAACGAGAAAGTATTCAGGCATTTGAAGAAAGCAAGATACCTTTTT	GCTTGCCTAAAAGACCATAATAAGTGCGTGATTTACTAAAATGAGAAAGTCATCTGCCTTTTTGCTTGCCTAAAATACCATAATGAGTGCGT
GATTTACTGAAAGGAGAAAGTATTCAGGCATTTGAAGAAAGTGATATGCCTTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096590163.1\|4603409_4604126_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|380375
NZ_AP018172.1\|WP_096590150.1\|4577819_4579607_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173865
NZ_AP018172.1\|WP_096590154.1\|4588115_4590875_-\|TIR-domain-containing-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018172.1\|WP_096590149.1\|4577107_4577806_+\|urea-ABC-transporter-ATP-binding-subunit-UrtE	unknown	unknown	gnl\|CDD\|274567
NZ_AP018172.1\|WP_096590152.1\|4581489_4584282_-\|malto-oligosyltrehalose-synthase	unknown	unknown	gnl\|CDD\|225819
NZ_AP018172.1\|WP_096595303.1\|4586519_4587434_+\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|225921
NZ_AP018172.1\|WP_096590161.1\|4601210_4602263_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381306
NZ_AP018172.1\|WP_096590151.1\|4579828_4581349_-\|alpha,alpha-trehalase	unknown	unknown	gnl\|CDD\|224541
NZ_AP018172.1\|WP_096590156.1\|4593188_4593599_-\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|225556
NZ_AP018172.1\|WP_096590159.1\|4599162_4599729_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590160.1\|4599770_4600835_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NZ_AP018172.1\|WP_096590153.1\|4584397_4586245_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NZ_AP018172.1\|WP_096590147.1\|4575183_4576305_+\|urea-ABC-transporter-permease-subunit-UrtC	unknown	unknown	gnl\|CDD\|132449
NZ_AP018172.1\|WP_096590157.1\|4593757_4594669_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_AP018172.1\|WP_096590158.1\|4594828_4599055_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_AP018172.1\|WP_096590155.1\|4590933_4593174_-\|DUF4071-domain-containing-protein	unknown	unknown	gnl\|CDD\|366883
NZ_AP018172.1\|WP_096590162.1\|4602393_4602963_+\|DNA-starvation/stationary-phase-protection-protein-Dps	unknown	unknown	gnl\|CDD\|236521
NZ_AP018172.1\|WP_096590146.1\|4574001_4575162_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|200272
NZ_AP018172.1\|WP_096590148.1\|4576279_4577026_+\|urea-ABC-transporter-ATP-binding-protein-UrtD	unknown	unknown	gnl\|CDD\|274568
NZ_AP018172.1\|WP_096590145.1\|4572593_4573898_+\|urea-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|372603

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096590163.1\|4603409_4604126_+\|pirin-family-protein	gnl\|CDD\|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	2.85988e-78
NZ_AP018172.1\|WP_096590150.1\|4577819_4579607_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173865	cd08500, PBP2_NikA_DppA_OppA_like_4, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_AP018172.1\|WP_096590154.1\|4588115_4590875_-\|TIR-domain-containing-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.43775e-85
NZ_AP018172.1\|WP_096590149.1\|4577107_4577806_+\|urea-ABC-transporter-ATP-binding-subunit-UrtE	gnl\|CDD\|274567	TIGR03410, urea_trans_UrtE, urea ABC transporter, ATP-binding protein UrtE. Members of this protein family are ABC transporter ATP-binding subunits associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	1.01896e-132
NZ_AP018172.1\|WP_096590152.1\|4581489_4584282_-\|malto-oligosyltrehalose-synthase	gnl\|CDD\|225819	COG3280, TreY, Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism].	0
NZ_AP018172.1\|WP_096595303.1\|4586519_4587434_+\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|225921	COG3386, COG3386, Gluconolactonase [Carbohydrate transport and metabolism].	2.31491e-68
NZ_AP018172.1\|WP_096590161.1\|4601210_4602263_+\|aldo/keto-reductase	gnl\|CDD\|381306	cd19080, AKR_AKR9A_9B, AKR9A and AKR9B families of aldo-keto reductase (AKR). The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.	0
NZ_AP018172.1\|WP_096590151.1\|4579828_4581349_-\|alpha,alpha-trehalase	gnl\|CDD\|224541	COG1626, TreA, Neutral trehalase [Carbohydrate transport and metabolism].	9.65065e-163
NZ_AP018172.1\|WP_096590156.1\|4593188_4593599_-\|DUF393-domain-containing-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	1.3313e-36
NZ_AP018172.1\|WP_096590160.1\|4599770_4600835_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	2.0512e-21
NZ_AP018172.1\|WP_096590153.1\|4584397_4586245_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_AP018172.1\|WP_096590147.1\|4575183_4576305_+\|urea-ABC-transporter-permease-subunit-UrtC	gnl\|CDD\|132449	TIGR03408, urea_trans_UrtC, urea ABC transporter, permease protein UrtC. Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	5.6417e-165
NZ_AP018172.1\|WP_096590157.1\|4593757_4594669_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.30661e-32
NZ_AP018172.1\|WP_096590158.1\|4594828_4599055_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.91982e-15
NZ_AP018172.1\|WP_096590155.1\|4590933_4593174_-\|DUF4071-domain-containing-protein	gnl\|CDD\|366883	pfam02026, RyR, RyR domain. This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.	4.99378e-40
NZ_AP018172.1\|WP_096590162.1\|4602393_4602963_+\|DNA-starvation/stationary-phase-protection-protein-Dps	gnl\|CDD\|236521	PRK09448, PRK09448, DNA starvation/stationary phase protection protein Dps; Provisional.	1.38735e-88
NZ_AP018172.1\|WP_096590146.1\|4574001_4575162_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|200272	TIGR03409, urea_trans_UrtB, urea ABC transporter, permease protein UrtB. Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	3.14466e-67
NZ_AP018172.1\|WP_096590148.1\|4576279_4577026_+\|urea-ABC-transporter-ATP-binding-protein-UrtD	gnl\|CDD\|274568	TIGR03411, urea_trans_UrtD, urea ABC transporter, ATP-binding protein UrtD. Members of this protein family are ABC transporter ATP-binding subunits associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines].	1.33368e-154
NZ_AP018172.1\|WP_096590145.1\|4572593_4573898_+\|urea-ABC-transporter-substrate-binding-protein	gnl\|CDD\|372603	pfam13433, Peripla_BP_5, Periplasmic binding protein domain. This domain is found in a variety of bacterial periplasmic binding proteins.	0

>NZ_AP018172.1|WP_096595303.1|4586519_4587434_+|SMP-30/gluconolactonase/LRE-family-protein
MVQHSSGNTSSTIQAIMNANTKLEKLVGGLKFTEGPVWHPRGFLLFSDIPADTIYKLTTNGKVSVFRRPAGHPNGNTFDTQGRLITAEHNRRLVRTEKNGEIKVLAQRYQGKLLNSPNDVVVKSDGSIYFTDPPYGISKEKEELGFYGIYRWQPNGTLNLLDRQMLRPNGIAFSPDDKKLYVSDSEQGYIRIFDVKLDGTLTNSRVFADLKEPKDKGVPDGLKIDIQGNIYCSGPEGVWIFSPTGQLLGKIIVPETVTNLAWGDNDYKTLYITAGQSVYRIRLKVRGQQPGRILDNRVSLNPKK
>NZ_AP018172.1|WP_096590153.1|4584397_4586245_-|malto-oligosyltrehalose-trehalohydrolase
MRTGANYLGNGECEFTVWSPTLNSVAVQILTPQEQVIPLKPQAEGYWQAKVNDVYPGTLYRYVLDKENAFADPASQYQPEGVHGPSQVIDPQFEWTDNNWTGVPLESMIFYELHVGTFTPEGTFTAIIPRLADLKELGINAIELMPIAQFPGDTHIEPSLAYRNWGYDGVYPFAIQNSYGTPADLKQLVNACHQHGIAVVLDVVYNHFGPEGNYMGQFAPYFTKTYKTPWGNAMNFDDAHSQGVRHYFIQNALYWLEDFHIDALRLDAIQAIYDLGAKHFLWELAEAVHSLSQNGGRKRYLIAESDLNNPQIIRPPELGGYGLDAQWSDDFHHALHALLTGDRQGYYQDFGQCAQLAKAYQDTFVYDWQYAPHRKRFHGISCRDRPPAQFSVCIQNHDQIGNQMKGDRLWNRISFEGLKLAAGAVLLSPYLPLLFMGEEYGETAPFMYFVSHSDPDLIQAVRAGRKQEFEAFHYDEDPPDPESAETFLRCKLNWQLRNQGQHKVLLNWYRELIDWRKAHPALLKQDRNCIEATSDEDKQLVIVRRWSESSQVIFALNFNQSPVTATLPIQRQAYKRLDSADTSWAGPGSQAPEDLSVGQELQLQPTSLVLYELEP
>NZ_AP018172.1|WP_096590152.1|4581489_4584282_-|malto-oligosyltrehalose-synthase
MRIPKATYRIQFTSQFNFDNAKAIASYLADLGISDLYASPIFKARSGSTHGYDVVDAAQLNPELGTTESFEALVSELQTLGMGWLQDIVPNHMAYSSENPYLMDVLEHGPDSSYTDYFDLSWNVPFGDRQERILAPLLGDFYGVSLEKGDIQLQYEQNGLTVNYYSLKLPLRLESYTKFLTYNLGKLTRTLGRNHPDFIKLLGILYILKNVPSEVAGKQRQDQIAFIKGLVWELYNSNDAIRDFIEENLKTFNGEAGNSESFNLLDDLLKDQFYRLAFWKVGAEEMNYRRFFTVNELISVKVEELRVFNNTHSLIQKLVEEGKFTGLRIDHIDGLYNPTQYLERLQEKMGDVYITVEKILELTEDLPENWRIQGTSGYDFLNYINGLFCQSENESQFDKIYHSFIGNKLDYASLVNKNKHLILEKNLAGDVDNLAILLKNISSKYRYGNDFTVNGLKRAIAEILTLFPIYRTYITPDGIHDSDRVYIEEVIRQAKEHAPLLQHEMDFIEKLMLLEFDESLTPTERDQWLYFVMRMQQYTGPLMAKGVEDTTLYAYNRLLSLNEVGGNPSHFGISLTDFHTFNQKHQANWPHTMNATATHDTKRGEDVRARLNVLSEIPNEWEEKVNSWSNLNQGLKSKHHRSSMPDRNDEYFLYQTLVGAFPFAEQEQSSFVERVKEYIIKSIREAKVHTAWLRPDNEYEEACTSFVEKVLDPSISKEFLADFRNFQQQIAEYGIFNSLSQTLLKIVAPGVPDFYQGTELWELSLVDPDNRRPVDFEQRRSYLSTIKQQIQTNILSLIQELLNQRNDGRIKLFLTVQALKARTDYLQLFQDGEYLPLEIQGTHANHIIAFARQQGNQTAIAIAPRFFTRLIQPREYPLGESVWQDTQLQLPKGTSSTWNNVLTQQSLEATGTLSIGAALAHFPVALLVSE
>NZ_AP018172.1|WP_096590151.1|4579828_4581349_-|alpha,alpha-trehalase
MTPQTSTQSPFTSTQINNLRTYIKKTWKTLTRSHSHLLQSAKDTKLEHKPGTPWIIYISPREDNPNIQSVLERSLSKEDMRQIEIRTLPPEAEAIKEHGLLYLPGPYVVPGGRFNEMYGWDSYFILLGLLRDEEWDLAQSQVDQLLYQVQHYGTILNSNRTYMLSRSQPPVLSLMVLALFQHTKDEEWLKSAVPLLEQFYYYWVVPPHLNPATGLSRYYALGEGPAPEVLFSERDEEGKSHYDRVKEYYQRFEIEDYDISLYYDKENDELSNLFYKGDRTMRESGFDISNRFGPFSIDIIHYAPVCLNSLLYQMEQDLAQINDILGNEELAQQWRDRADVRRDRIDRCLWDEKQGLYLDYHFQTETRRQYEFATTFYPLWVGVASDTQAKRVAENLSIFEAPGGIFTSTRVTGNQWDTPFGWAPLTLIAVQGLHRYGYHQEGDRIAHKFLAMVIKEFERRGILVEKYDVERCSANVSDEICFGYSSNEIGFGWTNGVVLELLATLA
>NZ_AP018172.1|WP_096590150.1|4577819_4579607_-|ABC-transporter-substrate-binding-protein
MIVPVFRHPQRLIALVLAVFFIIVGCQPTKFQTRVAQVSQLVLVSLSEPATFNYAINESPYSVFPFIYRGLLDENVITNKLEPALAESWSISPDRKRITFTLRKGLKWSDGEPLTADDVVFSYRDIYLNKKIPNTYRDLLRIGDTGAFPSVKKLDERQIEFTLPAPFAPFLRYTERLAILPAHALRSAVFSNDANGNPQFLSMWGTNTDPQKIICNGSYTIESYTPAQRVTFRRNPYYWRKDTEGNSQPYIKRIIWQIISSTDNQLLRFRSGELDSLNVTPSDFGLLKREEKRGKYTIYNGGPSSGFSFVGFNLNQARNAQGKPFVDPIKSQWFNNLAFRQAVAYAIDRNKIKTNIYRGLGEIQHSPIAVQSPYYLSPQAGLKVYNYNPNKARQMLLSAGFQYNSQKQLLDRDGNRVEFEMLVKSEDQSRIDAAVQIQQDLSQIGIKANLQVVSFNVVLRRLLSRRDWDCYVGAFGATGADVEPHLLNLFWSSRGSFHQFNQGPQPGAPPIQGWVVSDWEKEIDSLFNAGVKELDEKKRQAIYGRFQQIVAQQLPVFFLVNPISLQAVRDRVANIKYSGLGSVLWNLDEWQIINN
>NZ_AP018172.1|WP_096590149.1|4577107_4577806_+|urea-ABC-transporter-ATP-binding-subunit-UrtE
MLTISNLNVYYGESHILRNVDLSVPNGQMICLIGRNGVGKTTLLKTIMGLLKPRSGTINLAGNLINSRSPDQRAKMGIGYVPQGREIIPRLTVKENLLLGLEARRKPVKKAEIPEEIFSLFPVLKTMLSRMGGDLSGGQQQQLAIARALMGQPQLLVLDEPTEGIQPSIILEIEAAVRRIVETTGISVLLVEQHLHFVRQADHYYAMQKGAIVASGSTDELSQDVIQRFLAV
>NZ_AP018172.1|WP_096590148.1|4576279_4577026_+|urea-ABC-transporter-ATP-binding-protein-UrtD
MNAKILETENVTVSFDGFKALNQLNFSMDVGELRVVIGPNGAGKTTFLDVITGKVQPTIGRVLFKGKNLRSLPEHEIARRGIGRKFQTPRVYLNLTPRENLEITSNRNKNVFSTLFNRSHTIEQKSVQGLLETIGLTYKADIPAALLSHGEKQRLEIGMLVGQSPDLLLVDEPVAGLTDEETYNIGELLLTLAQSHSILVIEHDMEFVRQIAKKVTVLHEGSVLCEGNFEEVQNDPRVIEVYLGQQQE
>NZ_AP018172.1|WP_096590147.1|4575183_4576305_+|urea-ABC-transporter-permease-subunit-UrtC
MKQKQRRLILIEVGVVVAIALILIVIVPMVLSEFRLNLLGRFLSLAIVALGIDLIWGYTGLLSLGHGIFFGLGGYAIAMYLKLQVPQGELPDFMGLYGVTELPWFWRPFYSFPIAVAAVVLIPGLLAGLLGYLVFRNRIKGVYFSILTQAAIIVFFNFFNGQQQFFNGTNGLIDFTTLFGATVSDPKTKFIFYTLTVLFLTVTYGVCRWLTSGRFGKLLIAIRDDESRVRFSGYDPTDFKTLVFAVSGAIAGIAGAFYTLQSGSVSPRAMDIAFSIEMVIWVAVGGRATLIGAIIGTLLVNYARAFLSEQFSEIWLFFQGALFLIVVTVLPDGIVGWFRNQNIPLLKRPQEISTYPSLEIDPEVQHERQNLGN
>NZ_AP018172.1|WP_096590146.1|4574001_4575162_+|branched-chain-amino-acid-ABC-transporter-permease
MLTGFLDAVFNGISIGSVLLIAALGLAIIFGLMGVINMAHGELMMFGAYTTFLVQNGCKQLGGFWFEIYIFLALIFAFVFTACIGLILERGVIRYLYGRPLETLLATWGVSLIFQQFVRSVNWILVSGLILFCLLFFGGLWFLNSRTNLERIRNWVVGVIFLLSLGVTITTSNILSQTYQLAVTKPWFGAQNVDVTAPGWLQTGISLAGVQLPFARLFIIALTAICVGGIYLFLQRSSWGLKIRAVTQNRSMSACLGIPTQKVDAIAFALGSGLAGVAGCAISLLGSVGPNTGQNYIIDTFMVVVVGGVGNLAGTIVAALGIGTANFLIGSGTIASLLSPVKPLADFLTFFATTSMAKAMVFLLIIVFLQWKPAGMFPQKGRTVDV
>NZ_AP018172.1|WP_096590145.1|4572593_4573898_+|urea-ABC-transporter-substrate-binding-protein
MSRLNRRKFLIYSSATIGSSIFLKACVNNSPSTTNSPTASPVAAAGGGDKIKIGILHSLSGTMAISEKSVVDAEKLAIKEINANGGVLGKQIEAIVEDGASNWDTFREKATKLIDQDKVAVVFGCWTSASRKNVKPVFESKDHMLWYPVQYEGQECSKNIFYTGAAPNQQIEPSVDWLLKNKGKEFFLVGSDYVFPRTANTIIKAQLEALGGKTVGEDYLPLGNTEVTPIITKIKQTLPNGGVIYNTLNGDSNVAFFKQLKGAGLTPDKYPSMSVSIAEEEVKAIGVEYLKGHYAAWNYFQTVDTPANKKFVEAFKKEYGPDRVTNDPMEAAYIAVYLWKQAVEKAGSPDIAKVRTAAYGQTIDAPEGKVTVNANHHISKIVRIGEVRDDGLFNIVYATPAPVEPVPWNQFVKETKGFACDWSDPAKGGKYKKA
>NZ_AP018172.1|WP_096590154.1|4588115_4590875_-|TIR-domain-containing-protein
MANIFISYSRKDRVFVEKLHAALEEANCDAWVDWQDIPLTADWWHEIQRGIEGAHTFIFIISPDSVASKVCRQELEHSVKNSKRLIPILWREGFASEQVHEAVARHNWIFFREQDNFDRAFQSLLKAINTDLDYVYAHARLLVHALEWEAKARNDSFLLRGSDLQEAEQWLQQGASKEPKPTAQQVNYISKSREAEDAYQRLIRAGQKSRRMVQIGSAVLGLTICAAVVVSTMTMRALQELQAAKTATQLEREGATTLEQFNSDQLGALLAAVQSGKALQALVKDSQISQYPTTSPLFSLRTLLENIHEQNRIRADRSNASCARFSPDGSKIVTVDDRGTVRLWTATGQQLAEFRGHRGQVLDASFSPDGKTIATAGSDRTARLWNLSGKQLVEFKGHQGLIWSVSFSPDGQRLATASVDGTARLWSLTGQELVEFKGHQGQVAYVRFSPDGRQLVTVGSDRTARLWSLTGQQIREFTGHESSISEVSFSPDGKTIVTACDDGTARLWNLAGKTLAEFKGHLGAVLGVSFSPDGRRIATSGRDSTIRVWNLSGHQLAQFKATLWINSVSFSPDGQQLITAGGDGIARLWNISKRQITAFKASHGWIWSLNFSPDGKKIAVAGVDGVVRLWNLTGKQLAEFKGHQKSVWSLSFSPDGTKILTAGDDFARLWEITGKQIAEFGGHRQAIYRASLSPDGKRIVTSGENGIIRLWNISGQQTRSFQTNDGQIWSVKFSPDGKTIVTTGDRGTFHLWNLSGKPIAEFTGHQDIVFQANFSPDGKLIVTAGKDGTSRVWNLAGQQLALLRGHEGQVFDARFSPDDGQQIGTAGEDGTVRLWTITGQQIAKIRDYQGEVWNVAFNPQGHQIAIAGESGIVKLMPFDNADLEQLLARGCQWLHDYLQYNTDLSAGDRQICQGVGSRK
>NZ_AP018172.1|WP_096590155.1|4590933_4593174_-|DUF4071-domain-containing-protein
MNYKPEPIDTSKVIINTEHLKLTELLAKNTHEIWAQQRIAEGWKYGLQRDDLRKEHPGLIPYEELSESEKQYDRNTALGVIKMLLALGYRIEGETTSLPDEQQEQQLAVMLKNLQESSELNLSSLLAIGRETIKIKLHSPDIYIALGETILQLGEPLMAYDVITEGLKNWQNNLRLKQLLALALARSGATLRANSLLLELVEAGESDRETISILARTHKDLYLQATTPQEKQRHLELAAQRYQQAYQLTDDYYPGINAATMNLLRGDEATAREIAAQVREQCLQQSEKDYWQLATLGEAALILRGWSEAETWYKRAIEVGKGRLGDISSTRRNAKILLEYLEGDTQRLQEWFKLPRAVVFSGHIIDRPGRSIPRFPPELEAQVYRAIRDRLLALDAKIGYASVACGADILFLEAILELNGDIHIVLPYDREEFIKYSVDIIPHSNWKQRCEKLLARANEVITCSNRKLENSQVLYEYANCVVHGLGKMRAEVLDTELIHLAVWDGKPGDGSGGTAWAINTWQAWGYEVEIIDLESMLKASATNNNLSPDWQTEINIEPESSNNGESREVMALLFADVVKYSNLTESQIPQYVEYFLGSVAELEAQSSYKPLVKNTWGDALYYVFPSVTDAGNFALDLCELIQQIDWLEKGLPENLNLRISLHAGPVYQYVNPVTKDISYIGTHVNYAARIEPITPPGKVYTSQAFAALACALGVEDFTCDYVGQIPFAKGYGTFPTYHLRRQIKAF
>NZ_AP018172.1|WP_096590156.1|4593188_4593599_-|DUF393-domain-containing-protein
MNYYVIYDGNCNLCVSLVQLLESLDQGKLFRYSPMQNEQTLAQFGITPQDCEQGMILINANAPERRWQGSNAAEEIGRLLPLGSVFVDAYRALPGVKWVGDRFYEQIRDNRYTIFGKRDSTYQSSFCVDGNCQVGS
>NZ_AP018172.1|WP_096590157.1|4593757_4594669_+|AraC-family-transcriptional-regulator
MAEEKILTVDFTQRDACSEILPRSPLFSSYDANWNGVRLDHHQQPGYETPEHYCQQHIVTISLDQSVHKTERVFNGRLQSERIHYGDVVILPANTNHLSRWQLEAEFLVISLEPALFTRAAFEAGDLQRFEIVPRFASPDPLIQQIGLALQSELKSDGMGSRIYVESLTTTLCIHLLKHHSVSNNAITTYSQEQGLSQLKLRKAISYIQENLEQDLTLAEISAVVGMSMYHFSRLFKQSTGFAPHQYVMNCRIEKAKKLLTRTEQTIDQICQQVGFQNQSHFTNVFRKLMGTTPRVYREKVKI
>NZ_AP018172.1|WP_096590158.1|4594828_4599055_-|tetratricopeptide-repeat-protein
MLSQSDTRYFTGREEQLQQLEALLLNSQCSKVCSIVGVSGGGGIGKSALACHFATIHQDKFPDGVIGLRVDGKDVDTIAREFVRRCGEELDSEDDRDAATLMQEVFAHRQMLLIFDNAEEASIKKLRPGGNRCAVIVTTRRRHLPFSLDIEEQAIIDLPPLPEADALKLLKKILGSERVENAVAATQRLVKLVGNLPLALQVLGAALRGQREPLDDYTKALEQEKDELFEELKIEGDRDLNVEFSLNLSLKSLSEDEVDFFACLSVCAAEGFTKQTAMAAAGCQRNLQAQRCLKKLYDLSLLNYVDTGENRFVLHPLVREYAEALARKRELLAIAQERHAKFFVEWLQSDELTDETTIAEVAANLDDVILAAQWLQTREADTEQSKMETYQFALKLQPLFEQYGYWQKAITLMGQFQLWAEQLEDWYTVVRCKMHEARYWSFAEEFERAEEILKSSQAILQKIEDIDTRKRREAKVLNVLGGIFQKQGKTEQAIQTFRFQILIEEEIGDERSLAIVCNRLGKILQSQGKLEEAQQAFERGIAISEALNEQFSLAIGLNCLGGVLQQQGKLEEAQQDFERGIAIAQALNDQSSLAIGLNRLGGLLQQQGKLDQAQQAFERQIALAQALNDQSSLAIGLNRLGGLLQQQGKLDQAQQAFERQIALAQALNDQSQLAIGLNCLGGLLQQQGKLDQAQQTFERGIAIAQALNDQSQLAIGLNRLGGLLRQLGKLDQAQQTFERGIAIAEALNDQSQLAIGLNCLGGLLRQLGKLDQAQQTFERGIAIAEALNDQSSVAIGLSSLGGLLQQQGKLYQAQQVFEREIVIDEALNDQSSVAIGLNRLGGLLQQQGKLEEAQQAFERGIAIAEVLNDQSQIAIGLNCLGGLLQQQGKLEEAQQAFERGIAIAEVLNDQSQLAIGLNCLGRLLQQQGKLEEAQQAFERQIAIAEVLNDQSQLAIGLNRLGGLLQQQGKLEEAQQAFERQIAIAQALNNQSQLVIGLNCLGGLLQQQNKLQDALVTARLCVAIETELGVSRGLTMALTQVSQLLKATGQFQEAMTTLERIAQIEEELGNQRGLAMTLTSLASLQREHGYFDDAYNILLRIFAIENDLNNHERILWTLTNLAYIALQQEKFDLAIEYYERAVELSKNYGNEEVSASILNGMGIALHQYGTALLEQRTFGGKTVEVLEKSQEIFTHLNAPIQVAWVLHSLGRAWKLKGKFEKAEILLKDCQEIFEDKKDLPSLAKVLNTLGGVLERQQKWDEAEKILRQSYDLAVKLQDKRGQAIIANSLGQVLAHQEGVKAFELSQMYFRQSIKLGEELDEQKHLAKVHTAMGKAFLVRKGFDRAVEELSKGFEIDEMLSNVRGLIIVTPNLTYALSKLGRREEALQYCDRALKIAPNDPGFLQLRNKI
>NZ_AP018172.1|WP_096590159.1|4599162_4599729_-|hypothetical-protein
MPLKSELLKFLSRVPNTQTIPQRKALLAAVGFDWLVHQITWEGTNLVFFNELLELLRSEGQINLVNFLRSLADRDLNWVGLENGQKLITFAENISALTPEEWEREFWGDNRSQIKTSLNRMELIKTLGQLTTSDFDILVFSLKVPTNIIPPSTAPPGNRAFALLQWAESPMGCGLSDVEANLRSLLPQ
>NZ_AP018172.1|WP_096590160.1|4599770_4600835_-|trypsin-like-peptidase-domain-containing-protein
MINLDVEDRKQLITLLKDIPELATERSRLQILELAGLKQLAPMIDLSGTPFVAISEIVSYLSKYGRLTYDHEALGLFLNSLKSFVGIQQQAFLDGLLTKYDMMTPIAALPPIDLDQWKGGETTADVLEKIIGENTLRPIAFLQRGLEVARSVAYIGVQSGYERWSGTGFLVAEDLLLTNNHVLPSSDLLLNSIFRFNYEDDFWGRSQPSQEYHAKPSGLFHTNQELDYTLLQVDGEPGQKWGWLPLLSRNIKHRERVNIIQHPAGRPKEISFQNNFVEYVGGNVVQYITSTLNGSSGSPVLNDGWEVVALHHAGGNLPEPTTQRRYFRNEGILVEKILADLPLEIRELVNVAAN
>NZ_AP018172.1|WP_096590161.1|4601210_4602263_+|aldo/keto-reductase
MRYKLLGKSGLRVSELCLGTMTFGEDWGWGASQDESRRIFDTFVEAGGNFIDTANGYTDGTSEKIVGELIAQDRERFVVATKYSFPLRMNDNKNDPNGSGNHRKNLVQSLEGSLKRLNTDYIDLFWLHAWDFTTPVEEVMRSLDDMVRQGKILYVGISDAPAWIISQANTIAQYQGWTPFVALQVEYSLIQRTPERDLIPMAKALDLAVTPWSPLGGGVLTGKYNKPPQAGDEQGRLTNPTTGSISERSLAIADVVSQVAAEIGRTPSQVAIAWLRAQSGVIIPIIGARKLTQFQDNLAALDVNLSPEHLQRLHEVSQIELGFPHDFLQNDTIRDRLFGGTFSAIDNHRA
>NZ_AP018172.1|WP_096590162.1|4602393_4602963_+|DNA-starvation/stationary-phase-protection-protein-Dps
MSDNKIASRLYPTRIDIPAEARSQIVVLLNQTLAATLDLKTQVKQAHWNVKGTDFYQLHELFDEIAGELEEYIDMFAERVTALGGYALGTARAAASNSILPEYPFDVLDGIDHVTALADRFAPYAKHLRDAIAKTDDLGDLDTADLYTEVSRTIDKRLWFLEAHLQIAEIKAENGASAGKATKQPVAVK
>NZ_AP018172.1|WP_096590163.1|4603409_4604126_+|pirin-family-protein
MSQSTKNLVIHDGKLRGHTKISWLNSYHTFSFGSFYDPNYMGFRALRVINDDTVVPGAGFGTHGHRDMEILTYVLSGALEHKDSLGTGSVIRPGDAQIMSAGTGITHSEYNHSQTEPVHFLQIWMLPNKVGLTPRYDQKNFPVEEKRGKLRLIAAKDGRDGAVVVHQDLDLYASVLEKGDVVNYHLKSDRYAWLHVAQGAATLNGEELKAGDGVQISGEEKLEISTNASAEILLFDLA

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Crispr_ID: NZ_AP018172_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_13

4959962-4960072

Orphan

Consensus_repeat	Method
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018172_13

>merge|NZ_AP018172|13|4959962-4960072|CRISPRCasFinder
TCTTTCCAATCACACCGCCCCGAAAGGGGATGGAAACGAGAACTTGTCTGTAATTAAGTTTCATGTTTTTGTTTCTTTCCAATCACACCGCCCCGAAAGGGGATGGAAAAA

>NZ_AP018172|13|10|4959962-4960072|CRISPRCasFinder
TCTTTCCAATCACACCGCCCCGAAAGGGGATGGAAAC	GAGAACTTGTCTGTAATTAAGTTTCATGTTTTTGTT
TCTTTCCAATCACACCGCCCCGAAAGGGGATGGAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096590447.1\|4950602_4954643_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|380161
NZ_AP018172.1\|WP_096590442.1\|4947834_4948131_-\|nitrogenase	unknown	unknown	gnl\|CDD\|369150
NZ_AP018172.1\|WP_096590443.1\|4948127_4948565_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096595327.1\|4963441_4964179_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590449.1\|4957435_4958710_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224057
NZ_AP018172.1\|WP_096590453.1\|4962178_4962805_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NZ_AP018172.1\|WP_096590457.1\|4967798_4968446_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_AP018172.1\|WP_096590452.1\|4960530_4960821_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NZ_AP018172.1\|WP_096590458.1\|4968429_4969323_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP018172.1\|WP_096590448.1\|4954667_4957091_-\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_AP018172.1\|WP_096590455.1\|4966731_4967193_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|226357
NZ_AP018172.1\|WP_096590454.1\|4964297_4966397_-\|DUF1565-domain-containing-protein	unknown	unknown	gnl\|CDD\|284923
NZ_AP018172.1\|WP_096590446.1\|4949747_4950575_-\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|370378
NZ_AP018172.1\|WP_096595328.1\|4969536_4969773_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370236
NZ_AP018172.1\|WP_096590456.1\|4967182_4967620_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_AP018172.1\|WP_096590445.1\|4949188_4949692_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590450.1\|4958862_4959255_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590459.1\|4969781_4970450_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|198303
NZ_AP018172.1\|WP_096590451.1\|4959366_4959702_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590444.1\|4948757_4949132_-\|response-regulator	unknown	unknown	gnl\|CDD\|381104

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096590447.1\|4950602_4954643_-\|PAS-domain-S-box-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	1.38578e-62
NZ_AP018172.1\|WP_096590442.1\|4947834_4948131_-\|nitrogenase	gnl\|CDD\|369150	pfam06967, Mo-nitro_C, Mo-dependent nitrogenase C-terminus. This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria. Note that many family members are hypothetical proteins.	3.49806e-50
NZ_AP018172.1\|WP_096590449.1\|4957435_4958710_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224057	COG1134, TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	2.4016e-106
NZ_AP018172.1\|WP_096590457.1\|4967798_4968446_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.25714e-30
NZ_AP018172.1\|WP_096590452.1\|4960530_4960821_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.67463e-10
NZ_AP018172.1\|WP_096590458.1\|4968429_4969323_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.51533e-45
NZ_AP018172.1\|WP_096590453.1\|4962178_4962805_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	5.11375e-39
NZ_AP018172.1\|WP_096590455.1\|4966731_4967193_-\|cupin-domain-containing-protein	gnl\|CDD\|226357	COG3837, COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown].	5.09034e-57
NZ_AP018172.1\|WP_096590454.1\|4964297_4966397_-\|DUF1565-domain-containing-protein	gnl\|CDD\|284923	pfam07602, DUF1565, Protein of unknown function (DUF1565). These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterized domains such as pfam00395 and pfam03422.	1.29634e-48
NZ_AP018172.1\|WP_096590446.1\|4949747_4950575_-\|DUF1963-domain-containing-protein	gnl\|CDD\|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	3.56537e-33
NZ_AP018172.1\|WP_096595328.1\|4969536_4969773_+\|hypothetical-protein	gnl\|CDD\|370236	pfam09003, Arm-DNA-bind_1, Bacteriophage lambda integrase, Arm DNA-binding domain. The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage.	0.00444445
NZ_AP018172.1\|WP_096590456.1\|4967182_4967620_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.69807e-09
NZ_AP018172.1\|WP_096590459.1\|4969781_4970450_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|198303	cd03194, GST_C_3, C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	7.33982e-67
NZ_AP018172.1\|WP_096590448.1\|4954667_4957091_-\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.11663e-80
NZ_AP018172.1\|WP_096590444.1\|4948757_4949132_-\|response-regulator	gnl\|CDD\|381104	cd17552, REC_RR468-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains. Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.20629e-65

>NZ_AP018172.1|WP_096590451.1|4959366_4959702_+|hypothetical-protein
MSSVITEKFFILLNKVVSLLKKVFVLLNKVVSLLKKVFALLNKVVGLLKKVFVLLNKVVGLLKKVFALLNKVVGLLKKAFALLNKVLGLLTSVRRRRWRSHRISCLLAQNP
>NZ_AP018172.1|WP_096590450.1|4958862_4959255_-|hypothetical-protein
MPRVKKTSSILEKIEQQTIGFQSIDPSLDFGDSVSVKHLTDLTSELRDELKQYNKLLNTLDTAKEKIEILEKSIRETSERLVSGVASKYGKDSREYELAGAVRKSDRVRKATITRLKSSADAKAATTETA
>NZ_AP018172.1|WP_096590449.1|4957435_4958710_+|ABC-transporter-ATP-binding-protein
MHLFLMMMNFRDDSELLISVDKVSKKFCRNLKQSLFYGVQDIFQELIGGNRKSENLRPQEFWALKDVSFQLRRGEALGLVGANGAGKSTLLRIISGLINPDTGCVKVRGKLAPLIALGAGFNPILTGRENIYANMSILGLSTQEIDKKFQDVIDFAGIADAIDAPVQTYSSGMAARLGFACAVHIEPDVLLIDEVLAVGDINFRVKCYQKLAKLREAGTAFILVSHNPHVVLNVCENSLYLAKGELIKYGETETVIRQYEEDLSLGGTETSLGMMLLPEKPPSESLGIDIVSLSFKDEQGNILAAPLCGELAYLCVECKVDKQVDNANLGVSITALSGQNERILYITSASDNEALKILPGKVEIQMQMPYFCLLPGLYSAKIYIKEGVCSFDIVESFRFTVKASKITSRSLFYQPRKWKVINNS
>NZ_AP018172.1|WP_096590448.1|4954667_4957091_-|response-regulator
MRILLVEDDELIAKSLAKSLIDQHYAVDVAKDGQAGWDLAELFTYDLILLDVLLPKLNGIQFCQRLRANGNLTPVLLLTAQDTSTNKVMGLDAGADDYVAKPFDFQELLARVRALLRRGGSALPPLLEWKNLRLDPSTCEVTCNGKLLHLTPKEYGLLELFLRNNHRIFSCSALIDHLWSFEEPPTDDTVRSHMKGLRQKLKAAGVADDPIETVYGIGYKLKPADREGVGKGKSKSSIAGNDGRRGRQQQPQSPQPNWLQNHAPNNNGKKPPANVQNQVATGVSKVWEEVAQKLEERVATIEQASTMLRQGKVSQEMQLKAKLEAHKLVGSLGMFGSDEGSHLAQELESLWDMGTQLQPETTQQISQLVVALRQELQLLNSEYKQDLLCENQLVDERPLLLIVNQDRELAEALAKETNSWAMRSQIANDAIAAREAIAKNSPDVILLDLCASNSTENTLALLAELNARQSPIPAIVLTDKDSLLDRVKVARLGGSGVLQKPVSPNQILETVTQILQRTRSAEAKVMVVDDDPHILAALQNLLMPWGLKVYTLENPLRFLEAIAVAQPDLIILDVEMPEVSGIELCQVIRNDPQWSGLPILFLTAHSDTKTRQQVFLAGADDYISKPIVEPELITRILNRLERSRWLRNLAELDGLTLVANRRKSTEDLNRYLQSSERHQQPFCFAIVELDNLKEINHQYGHAVGDRVLSRLGELLRQTFHTQDVVGRWGGSEFVIGMAGMTKSDGVRRLLELLQSLRQIEFTAANNQKFHTTFTTAVVEYPQDGANLQALYQAADAVLEQAKRSVGV
>NZ_AP018172.1|WP_096590447.1|4950602_4954643_-|PAS-domain-S-box-protein
MSELLQTFLTSSPFIPHGHCYLWNPGLVFLHVLSDALIVLAYYFIPLTLLYFVYKGNTFPFKTIFLLFSAFIIACGTTHLMSIWTLWYPNYWVSGAVKAVTAITSVYAALVLVKLLPKALEILNTVQLEVTNQKLQQQIIERQKIEAALRDSERRFRAIFDQTFQFIGLLQPDGTLLEVNRTALNFGGLTHADVINRPLWETRWWTISPQIQNRLKTAIAQAACGQFVRYEVDLRGAEDTQAMVDFSLKPIFDEAGKVVILIAEGRDISAVYYELLLRKHAEAALRRAHDELEIRVQERTTEVLAANEALQAEITERQRIESELRDTTRLQRAILNSANYTIISTTAEGIILTFNAAAERSLGYTAQEVVGKTTPAIIHDWDEIVQVAQELSQELGVTIEPGFEVFVAKARRGQVEEREWTYIRKDGSRFPLLLSVTALRDAENNITGFLGIGSDISNSKLTQEALSQSEATLRSFFDSAPMLMGVVEVLDDDVLHISDNAAAAKFYGLTPAAMQNRLASEMGAPQNYINQWIEYYRAAERNHAPVRFEYAHETPTDKKWLSATVSAINSDRADRPRFSYIVEDISERKHSEEELRQQAFLLDLTHDTIIVRDASARITFWNRGAEEMYGWTKAEAIGQISHEFLQTQFPQPLTEIEAQLLETGRWEGELVHSKRNGTPVVVSSRWALQRDEQGKVERILEINNDITERQQAEEEFRHLSLALESAVEGISQLDTQGRYIKVNPAYANTVGYQAEEIIGMEWVSTVHPEDLETLNAAYQLMLTNGKVDVEARGLRKDKSVFDKQVVMVKAYDRQQRFIGHYCFMKDISDRREIERLKDEFVSVVSHELRTPLTSVAGALDLLAGGVLLAEPEEAQRMLKIAASNTDRLVRLINDILDIERIESGKVQMTPEICDAGELITESVETVEEMAEQAGVTISVSPLSAPIWADPDRIIQVFTNLLSNAIKFSPPGSTIWLSGEILAGKQIRFQVKDQGRGIPSEKLESVFERFGQVDASDSRQKGGTGLGLAICRSILQHHQGQIWVESTLGAGSNFFFTLPLLSEEETRQRNRENQENLSPSVLIPITAASASPLVLECDDDPSVRVVVQTMLERQGYRVMVAASGQEAVEQAKLYHPDAIILNLMMPGMDGWETLAILKQQPHTQNIPVIILSGLLPDANKDLAQSVSDWIVKPPNPKLLCQALEKATATQNPCIKVLIIEDDLDLAQVLIALFNRHGITTFYAQTGREAIQISQNILPDLLVLDLGLPENDGFAVVDWLRQHQRLCQVPLVVYTARDLDESDRDRLKLGQTLFFTKGRITPQEFEQRVINLLNRMIGDRSEVSQDSI
>NZ_AP018172.1|WP_096590446.1|4949747_4950575_-|DUF1963-domain-containing-protein
MIDNILHDLPPEFEPLRSLLEANLSPYIKIIAAEAGHLNSAGYPNFDWGGDPLELWQSKIGGHPYLPKGTSYPVDGETGEMMMFLMQVNCADLPIIDGFALPRQGILQFYSGLDVPMSELSPEKHHILYFPEISQDKNNLVTDFSFLANASKEFEWYDDIYALKFALQYDVFWQARSVYNPLNIPEDLRKLSREFDEWIRDYELDNNIVEQRGNKLGGYVELHSYVEETIEEPQGRLLLELNHPFEVDDNFYFFIEESDLVNLDFSKAQSYFLRE
>NZ_AP018172.1|WP_096590445.1|4949188_4949692_-|hypothetical-protein
MLDYLLPLLLVTPFIAVGAIAFNYNHSLLSLVVVLLGAIAGAISIALSGIYWLQIFHHRWMESQAAGFIFVPITLPICAYTGAVAGGSLAAILYRYQVSDLPSPIFQIIAIGFTIVLAGLIPSAIATISFSEVNKFIIAPIVIICGSVVSSWFATKLAYLFVTNLFQ
>NZ_AP018172.1|WP_096590444.1|4948757_4949132_-|response-regulator
MIAKHILIIDDEYDIRAVAELALKAVGAWQVSTAASGSEGVAKAIAEQPDAILLDVMMPDMDGIATFQALQANPATQSIPVILLTAKAQATEKRRFAELAVKAIITKPFKAMKLPAQIAAALNW
>NZ_AP018172.1|WP_096590443.1|4948127_4948565_-|hypothetical-protein
MEDLELFHFHLERAIYILNFKDKKLAECWVTQLHSSMGFAYTDSFLTAAVLELSITDIDTFHWVLDNLSAWKPYTQLLAQVTKFVLKKLINKGFIPSIDFSFDAQGKILLHENTKNVILADTSDSDRLLIEKVVLTPKQVHSLIT
>NZ_AP018172.1|WP_096590442.1|4947834_4948131_-|nitrogenase
MMFTSKFTANYLAKVLLQPLRQKLESLKIENCRLARLLCKIIPASCPFEREIKLCDRTLISIPPLCKLNPFYEQLIELRFKALSYLADECGEDITVYC
>NZ_AP018172.1|WP_096590452.1|4960530_4960821_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MSFDLRNIHPLSEFQRSAKTFLTTLKDTQAPIVLTVNGKAAVVVQDAESYQRLLERLELLESLAGIRKSLDEFEQGQGIPLDEAFQQLRQKHDIPD
>NZ_AP018172.1|WP_096590453.1|4962178_4962805_+|glutathione-S-transferase-family-protein
MKLYYIPTTRAVRPRWLLEEIGVPYELIQVDMSMTQEPEYKKLHPHGKVPILIDGEVTIFESAAICAYLADKYQTMGFAPAIDSPERGYYYQWLFYATATLEPPVEHFMFDVLPNLPEKILPIKARSAVSTQEALQWFDKVSLPLTELLSDKNYLVADKFSAADIVTGGVLLWAFKLGMLKDDSPLNRYIKRLMERPALMRADEDFVS
>NZ_AP018172.1|WP_096595327.1|4963441_4964179_-|hypothetical-protein
MLKPVKDPSTELATALLTHYSFDLSGYSASELIRRWKNQYPIEWLHIAVIEALYQGRYKAVSVQQILNFWHRRGQATYHFNMEFERLICSKFPESLTSIPTPVLYPAKKIATPVEKTNYHLASSSANPEPSPPKATRDYSQRALPPLKVVREAETQLASEDTQEIATSATHNAANTEPTQAESELQPSFQPESQLQANSPVYPASNRPQRLLPVGVNHRAIGQFTPEKSDRTESFASKLKAMSGG
>NZ_AP018172.1|WP_096590454.1|4964297_4966397_-|DUF1565-domain-containing-protein
MVNSTLVTTLYINSVQGNDANAGSRLSPFKSLTRALKASTKSTIIQLGPGTYSAATGEVFPLIIPAGVIVVGNEASKGAGIVIIGNGTYQSPSFGTQNITLMLQEDASLRGVTVTNTTSKGTGVWIESTAPTVSSNTFINCAREGVFTTGAAKPAILDNVFLQNAASGLTMARNSKGEVLRNVFQKNTLGIAISDSAAPLVANNKLSENQTAIALSRDARPVLRQNIITSNIQGGLLVNGNAIPDLGSTQDAAGNVFRDNKEYDLQNVTSQQLVSVGNQLNPILVKGAVDFLSATVESAGQVSVGTSFYDLGGHWAVAFVEALVSKNYLSGFPDGSFSPNSPITRAQYAAIIAKTFPPPNGSKVSNFTDVNPDYWAASAILRAANMGFISGFPDGTFRPGQNLTRIQAIVSIVNGLKWSGGNSNVLTVYRDRAQIPSYATNAVAIATQKLLVVNYPKTEQLEPLRDISRAEVAAIIYQALVAIGQEKAIPSPYIVNPDPDIASFSDLKGHWAETFIRALVSMGLTTGFADGSYQPDKPMTRAQYAALVAGAFNPTPQRPAIDFTDVAKDFWAAKAIQTAAMGGFVSGFSDRTFRPDQNVQRLQVIVSLVNGLALPAADNDNLLVYSDRNAIPEYARKAVATATQQQIAVNYPDPKQLVPVREATRAEVAAMVYQALVAIQRANAIKSPYIVSQITQLTK
>NZ_AP018172.1|WP_096590455.1|4966731_4967193_-|cupin-domain-containing-protein
MIINPENVPDRTTTLYPQEFKPLVMGRVKKAVGNAAGLKNFGVNLVTMAPGSRSSLRHWHTRQDEFIYIIEGEVTLVTNEGEQILQPGMMAGFPAGEANGHHLVNHSPETVIYLEIGDRTADDQAHYPDDDLMAQASANGWMFTRKDGTLYES
>NZ_AP018172.1|WP_096590456.1|4967182_4967620_-|GNAT-family-N-acetyltransferase
MTYQTVDQLTDNQIVELVDLYKNEFWSKKRTYQDVVKMLAASDIIIALVDDNKQLIGFTRILTDFVYRATVYDVIIKPTHRKMGLGAKLIDAAIHHPQLSEVEQIALYCLPEMIPFYQRWGFTNELSGMQLMYRYNLRSPKTNDY
>NZ_AP018172.1|WP_096590457.1|4967798_4968446_+|Uma2-family-endonuclease
MFALVSLEKIQLPSGSVVRLPATWQEYQILCQQRGDGSIPRIKYRDGEVLLMSPLPVHGRDANLLADIVKALLDDDRREYDAFTPVTMELPEESGIEPDYCFYIDDWQAISGKKRIDWQQDPPPDLVIEIDVTSYSDVQDYLPYRVPEVWLFKKQRLLIYQLQGDDYQLQTQSHYFPEFDLQNLIASCVKIAYERNTSAAIRHLKQQIFQVNKSI
>NZ_AP018172.1|WP_096590458.1|4968429_4969323_-|LysR-family-transcriptional-regulator
MKLSQLRAVVAVADCGNFSEAALELQLSQPAISHAIATLEEELGVPLFARGRHGAVLTPAGERILYHARQSLQHLEMMHKEANLHKGLHGGHVRIAAFRSVATHLLPKAIAQFHDQFPEVAVTIIESLSYIEVEQCLREGRADIGITYLPTSDEFEVWEIVRDEYVALLPPKAKVSSPTITWEDIAVYSPVLLSCLPCGRSLHNHLKNVASFMNTISDIQEDSTIVSLVNQGLRAAIIPRLAAVPIPQNVQVYSLPIPLERVMAVALLSNGLHIPAVFTFLEMLKKFDFYTLAKSTY
>NZ_AP018172.1|WP_096595328.1|4969536_4969773_+|hypothetical-protein
MKISSRTGNIFTSVCQALHSFWQNTMQTLLAPDELQVIQKVDRYGNIYWQAYDPVTGKSFSSGSEVDVSMWIEQLYRH
>NZ_AP018172.1|WP_096590459.1|4969781_4970450_+|glutathione-S-transferase-family-protein
MTQLTLVIGNKNYSSWSLRPWLALKQFGVQFDEIRIPLYTPETASKLQQYSPSGKVPALLHNNQTIWDSLAICEYLAEEFPHLHWWPEDKIARALARSISAEMHSGFQNLRQNMPMNCRAKLPGKGLTSEVQKDIDRITSIWQEFRQKFAADGDFLLGKFTIADAMFAPVVLRFVTYDVQLDSISQKYAETILELPAMQQWLEAAKNETEVLAQYEFYSNQN

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Crispr_ID: NZ_AP018172_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_14

4961296-4962048

Orphan

Consensus_repeat	Method
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CRISPRCasFinder
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	PILER-CR
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CRT

10 spacers

The CRISPR arrays of NZ_AP018172_14

>merge|NZ_AP018172|14|4961296-4962048|CRISPRCasFinder,PILER-CR,CRT
TCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACTTTGGACTGTGTGACCCACTTATCTTTTCCATTACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACCAGAAGTCGTTGCTTGTGCAGCAATCACGACTTGTCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACGTTTGCATCGAATTATCCGGCATAATGAATAAATTATACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACGTCTCGATTATCAATTTAAGTGTTTGGTACAAACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACCTTAGTCACCTCACCGTGTCTACTAAACGGTGACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACTCGCTGCTGATACCAGAAGATAAGGTAATGCAAACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACGAGTCATTGTTGGCAACCGGTAATTTAAATGTTACTCCACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACACCCATGAGTAGTCTGCACATTCTGCGGCGGTGGTGCCGACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACGCCTGGCTGGAACTTTACAGCGTTATTGCTGCTGCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAACTCATCTGCGTATACGTCAAGCAGCAGATGTACTCGACTTTGCGATCGCATCACCCCGAAAGGGGATGGAAAC

>NZ_AP018172|14|11|4961296-4962048|CRISPRCasFinder
TCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TTTGGACTGTGTGACCCACTTATCTTTTCCATT
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CAGAAGTCGTTGCTTGTGCAGCAATCACGACTTG
TCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GTTTGCATCGAATTATCCGGCATAATGAATAAATTAT
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GTCTCGATTATCAATTTAAGTGTTTGGTACAA
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CTTAGTCACCTCACCGTGTCTACTAAACGGTG
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TCGCTGCTGATACCAGAAGATAAGGTAATGCAA
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GAGTCATTGTTGGCAACCGGTAATTTAAATGTTACTCC
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	ACCCATGAGTAGTCTGCACATTCTGCGGCGGTGGTGCCG
ACTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GCCTGGCTGGAACTTTACAGCGTTATTGCTGCT
GCTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TCATCTGCGTATACGTCAAGCAGCAGATGTACTCG
ACTTTGCGATCGCATCACCCCGAAAGGGGATGGAAAC

>NZ_AP018172|14|8|4961297-4961976|PILER-CR
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TTTGGACTGTGTGACCCACTTATCTTTTCCATTA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CAGAAGTCGTTGCTTGTGCAGCAATCACGACTTGT
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GTTTGCATCGAATTATCCGGCATAATGAATAAATTATA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GTCTCGATTATCAATTTAAGTGTTTGGTACAAA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CTTAGTCACCTCACCGTGTCTACTAAACGGTGA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TCGCTGCTGATACCAGAAGATAAGGTAATGCAAA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GAGTCATTGTTGGCAACCGGTAATTTAAATGTTACTCCA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	ACCCATGAGTAGTCTGCACATTCTGCGGCGGTGGTGCCGA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GCCTGGCTGGAACTTTACAGCGTTATTGCTGCTG
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC

>NZ_AP018172|14|8|4961297-4962048|CRT
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TTTGGACTGTGTGACCCACTTATCTTTTCCATTA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CAGAAGTCGTTGCTTGTGCAGCAATCACGACTTGT
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GTTTGCATCGAATTATCCGGCATAATGAATAAATTATA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GTCTCGATTATCAATTTAAGTGTTTGGTACAAA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	CTTAGTCACCTCACCGTGTCTACTAAACGGTGA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TCGCTGCTGATACCAGAAGATAAGGTAATGCAAA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GAGTCATTGTTGGCAACCGGTAATTTAAATGTTACTCCA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	ACCCATGAGTAGTCTGCACATTCTGCGGCGGTGGTGCCGA
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	GCCTGGCTGGAACTTTACAGCGTTATTGCTGCTG
CTTTCCGATCACATCGCCCCGAAAGGGGATGGAAAC	TCATCTGCGTATACGTCAAGCAGCAGATGTACTCGA
CTTTGCGATCGCATCACCCCGAAAGGGGATGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096590447.1\|4950602_4954643_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|380161
NZ_AP018172.1\|WP_096590455.1\|4966731_4967193_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|226357
NZ_AP018172.1\|WP_096590443.1\|4948127_4948565_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096595327.1\|4963441_4964179_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590449.1\|4957435_4958710_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224057
NZ_AP018172.1\|WP_096590457.1\|4967798_4968446_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_AP018172.1\|WP_096590451.1\|4959366_4959702_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590453.1\|4962178_4962805_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NZ_AP018172.1\|WP_096590458.1\|4968429_4969323_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP018172.1\|WP_096590454.1\|4964297_4966397_-\|DUF1565-domain-containing-protein	unknown	unknown	gnl\|CDD\|284923
NZ_AP018172.1\|WP_096590446.1\|4949747_4950575_-\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|370378
NZ_AP018172.1\|WP_096595328.1\|4969536_4969773_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370236
NZ_AP018172.1\|WP_096590456.1\|4967182_4967620_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_AP018172.1\|WP_096590445.1\|4949188_4949692_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590450.1\|4958862_4959255_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590459.1\|4969781_4970450_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|198303
NZ_AP018172.1\|WP_096590452.1\|4960530_4960821_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NZ_AP018172.1\|WP_096590444.1\|4948757_4949132_-\|response-regulator	unknown	unknown	gnl\|CDD\|381104
NZ_AP018172.1\|WP_096590460.1\|4970596_4971007_-\|response-regulator	unknown	unknown	gnl\|CDD\|381118
NZ_AP018172.1\|WP_096590448.1\|4954667_4957091_-\|response-regulator	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096590447.1\|4950602_4954643_-\|PAS-domain-S-box-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	1.38578e-62
NZ_AP018172.1\|WP_096590455.1\|4966731_4967193_-\|cupin-domain-containing-protein	gnl\|CDD\|226357	COG3837, COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown].	5.09034e-57
NZ_AP018172.1\|WP_096590449.1\|4957435_4958710_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224057	COG1134, TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	2.4016e-106
NZ_AP018172.1\|WP_096590457.1\|4967798_4968446_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.25714e-30
NZ_AP018172.1\|WP_096590452.1\|4960530_4960821_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.67463e-10
NZ_AP018172.1\|WP_096590453.1\|4962178_4962805_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	5.11375e-39
NZ_AP018172.1\|WP_096590458.1\|4968429_4969323_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.51533e-45
NZ_AP018172.1\|WP_096590454.1\|4964297_4966397_-\|DUF1565-domain-containing-protein	gnl\|CDD\|284923	pfam07602, DUF1565, Protein of unknown function (DUF1565). These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterized domains such as pfam00395 and pfam03422.	1.29634e-48
NZ_AP018172.1\|WP_096590446.1\|4949747_4950575_-\|DUF1963-domain-containing-protein	gnl\|CDD\|370378	pfam09234, DUF1963, Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	3.56537e-33
NZ_AP018172.1\|WP_096595328.1\|4969536_4969773_+\|hypothetical-protein	gnl\|CDD\|370236	pfam09003, Arm-DNA-bind_1, Bacteriophage lambda integrase, Arm DNA-binding domain. The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage.	0.00444445
NZ_AP018172.1\|WP_096590456.1\|4967182_4967620_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.69807e-09
NZ_AP018172.1\|WP_096590459.1\|4969781_4970450_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|198303	cd03194, GST_C_3, C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	7.33982e-67
NZ_AP018172.1\|WP_096590448.1\|4954667_4957091_-\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.11663e-80
NZ_AP018172.1\|WP_096590444.1\|4948757_4949132_-\|response-regulator	gnl\|CDD\|381104	cd17552, REC_RR468-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains. Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.20629e-65
NZ_AP018172.1\|WP_096590460.1\|4970596_4971007_-\|response-regulator	gnl\|CDD\|381118	cd17580, REC_2_DhkD-like, second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains. Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	6.89153e-39

>NZ_AP018172.1|WP_096590452.1|4960530_4960821_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MSFDLRNIHPLSEFQRSAKTFLTTLKDTQAPIVLTVNGKAAVVVQDAESYQRLLERLELLESLAGIRKSLDEFEQGQGIPLDEAFQQLRQKHDIPD
>NZ_AP018172.1|WP_096590451.1|4959366_4959702_+|hypothetical-protein
MSSVITEKFFILLNKVVSLLKKVFVLLNKVVSLLKKVFALLNKVVGLLKKVFVLLNKVVGLLKKVFALLNKVVGLLKKAFALLNKVLGLLTSVRRRRWRSHRISCLLAQNP
>NZ_AP018172.1|WP_096590450.1|4958862_4959255_-|hypothetical-protein
MPRVKKTSSILEKIEQQTIGFQSIDPSLDFGDSVSVKHLTDLTSELRDELKQYNKLLNTLDTAKEKIEILEKSIRETSERLVSGVASKYGKDSREYELAGAVRKSDRVRKATITRLKSSADAKAATTETA
>NZ_AP018172.1|WP_096590449.1|4957435_4958710_+|ABC-transporter-ATP-binding-protein
MHLFLMMMNFRDDSELLISVDKVSKKFCRNLKQSLFYGVQDIFQELIGGNRKSENLRPQEFWALKDVSFQLRRGEALGLVGANGAGKSTLLRIISGLINPDTGCVKVRGKLAPLIALGAGFNPILTGRENIYANMSILGLSTQEIDKKFQDVIDFAGIADAIDAPVQTYSSGMAARLGFACAVHIEPDVLLIDEVLAVGDINFRVKCYQKLAKLREAGTAFILVSHNPHVVLNVCENSLYLAKGELIKYGETETVIRQYEEDLSLGGTETSLGMMLLPEKPPSESLGIDIVSLSFKDEQGNILAAPLCGELAYLCVECKVDKQVDNANLGVSITALSGQNERILYITSASDNEALKILPGKVEIQMQMPYFCLLPGLYSAKIYIKEGVCSFDIVESFRFTVKASKITSRSLFYQPRKWKVINNS
>NZ_AP018172.1|WP_096590448.1|4954667_4957091_-|response-regulator
MRILLVEDDELIAKSLAKSLIDQHYAVDVAKDGQAGWDLAELFTYDLILLDVLLPKLNGIQFCQRLRANGNLTPVLLLTAQDTSTNKVMGLDAGADDYVAKPFDFQELLARVRALLRRGGSALPPLLEWKNLRLDPSTCEVTCNGKLLHLTPKEYGLLELFLRNNHRIFSCSALIDHLWSFEEPPTDDTVRSHMKGLRQKLKAAGVADDPIETVYGIGYKLKPADREGVGKGKSKSSIAGNDGRRGRQQQPQSPQPNWLQNHAPNNNGKKPPANVQNQVATGVSKVWEEVAQKLEERVATIEQASTMLRQGKVSQEMQLKAKLEAHKLVGSLGMFGSDEGSHLAQELESLWDMGTQLQPETTQQISQLVVALRQELQLLNSEYKQDLLCENQLVDERPLLLIVNQDRELAEALAKETNSWAMRSQIANDAIAAREAIAKNSPDVILLDLCASNSTENTLALLAELNARQSPIPAIVLTDKDSLLDRVKVARLGGSGVLQKPVSPNQILETVTQILQRTRSAEAKVMVVDDDPHILAALQNLLMPWGLKVYTLENPLRFLEAIAVAQPDLIILDVEMPEVSGIELCQVIRNDPQWSGLPILFLTAHSDTKTRQQVFLAGADDYISKPIVEPELITRILNRLERSRWLRNLAELDGLTLVANRRKSTEDLNRYLQSSERHQQPFCFAIVELDNLKEINHQYGHAVGDRVLSRLGELLRQTFHTQDVVGRWGGSEFVIGMAGMTKSDGVRRLLELLQSLRQIEFTAANNQKFHTTFTTAVVEYPQDGANLQALYQAADAVLEQAKRSVGV
>NZ_AP018172.1|WP_096590447.1|4950602_4954643_-|PAS-domain-S-box-protein
MSELLQTFLTSSPFIPHGHCYLWNPGLVFLHVLSDALIVLAYYFIPLTLLYFVYKGNTFPFKTIFLLFSAFIIACGTTHLMSIWTLWYPNYWVSGAVKAVTAITSVYAALVLVKLLPKALEILNTVQLEVTNQKLQQQIIERQKIEAALRDSERRFRAIFDQTFQFIGLLQPDGTLLEVNRTALNFGGLTHADVINRPLWETRWWTISPQIQNRLKTAIAQAACGQFVRYEVDLRGAEDTQAMVDFSLKPIFDEAGKVVILIAEGRDISAVYYELLLRKHAEAALRRAHDELEIRVQERTTEVLAANEALQAEITERQRIESELRDTTRLQRAILNSANYTIISTTAEGIILTFNAAAERSLGYTAQEVVGKTTPAIIHDWDEIVQVAQELSQELGVTIEPGFEVFVAKARRGQVEEREWTYIRKDGSRFPLLLSVTALRDAENNITGFLGIGSDISNSKLTQEALSQSEATLRSFFDSAPMLMGVVEVLDDDVLHISDNAAAAKFYGLTPAAMQNRLASEMGAPQNYINQWIEYYRAAERNHAPVRFEYAHETPTDKKWLSATVSAINSDRADRPRFSYIVEDISERKHSEEELRQQAFLLDLTHDTIIVRDASARITFWNRGAEEMYGWTKAEAIGQISHEFLQTQFPQPLTEIEAQLLETGRWEGELVHSKRNGTPVVVSSRWALQRDEQGKVERILEINNDITERQQAEEEFRHLSLALESAVEGISQLDTQGRYIKVNPAYANTVGYQAEEIIGMEWVSTVHPEDLETLNAAYQLMLTNGKVDVEARGLRKDKSVFDKQVVMVKAYDRQQRFIGHYCFMKDISDRREIERLKDEFVSVVSHELRTPLTSVAGALDLLAGGVLLAEPEEAQRMLKIAASNTDRLVRLINDILDIERIESGKVQMTPEICDAGELITESVETVEEMAEQAGVTISVSPLSAPIWADPDRIIQVFTNLLSNAIKFSPPGSTIWLSGEILAGKQIRFQVKDQGRGIPSEKLESVFERFGQVDASDSRQKGGTGLGLAICRSILQHHQGQIWVESTLGAGSNFFFTLPLLSEEETRQRNRENQENLSPSVLIPITAASASPLVLECDDDPSVRVVVQTMLERQGYRVMVAASGQEAVEQAKLYHPDAIILNLMMPGMDGWETLAILKQQPHTQNIPVIILSGLLPDANKDLAQSVSDWIVKPPNPKLLCQALEKATATQNPCIKVLIIEDDLDLAQVLIALFNRHGITTFYAQTGREAIQISQNILPDLLVLDLGLPENDGFAVVDWLRQHQRLCQVPLVVYTARDLDESDRDRLKLGQTLFFTKGRITPQEFEQRVINLLNRMIGDRSEVSQDSI
>NZ_AP018172.1|WP_096590446.1|4949747_4950575_-|DUF1963-domain-containing-protein
MIDNILHDLPPEFEPLRSLLEANLSPYIKIIAAEAGHLNSAGYPNFDWGGDPLELWQSKIGGHPYLPKGTSYPVDGETGEMMMFLMQVNCADLPIIDGFALPRQGILQFYSGLDVPMSELSPEKHHILYFPEISQDKNNLVTDFSFLANASKEFEWYDDIYALKFALQYDVFWQARSVYNPLNIPEDLRKLSREFDEWIRDYELDNNIVEQRGNKLGGYVELHSYVEETIEEPQGRLLLELNHPFEVDDNFYFFIEESDLVNLDFSKAQSYFLRE
>NZ_AP018172.1|WP_096590445.1|4949188_4949692_-|hypothetical-protein
MLDYLLPLLLVTPFIAVGAIAFNYNHSLLSLVVVLLGAIAGAISIALSGIYWLQIFHHRWMESQAAGFIFVPITLPICAYTGAVAGGSLAAILYRYQVSDLPSPIFQIIAIGFTIVLAGLIPSAIATISFSEVNKFIIAPIVIICGSVVSSWFATKLAYLFVTNLFQ
>NZ_AP018172.1|WP_096590444.1|4948757_4949132_-|response-regulator
MIAKHILIIDDEYDIRAVAELALKAVGAWQVSTAASGSEGVAKAIAEQPDAILLDVMMPDMDGIATFQALQANPATQSIPVILLTAKAQATEKRRFAELAVKAIITKPFKAMKLPAQIAAALNW
>NZ_AP018172.1|WP_096590443.1|4948127_4948565_-|hypothetical-protein
MEDLELFHFHLERAIYILNFKDKKLAECWVTQLHSSMGFAYTDSFLTAAVLELSITDIDTFHWVLDNLSAWKPYTQLLAQVTKFVLKKLINKGFIPSIDFSFDAQGKILLHENTKNVILADTSDSDRLLIEKVVLTPKQVHSLIT
>NZ_AP018172.1|WP_096590453.1|4962178_4962805_+|glutathione-S-transferase-family-protein
MKLYYIPTTRAVRPRWLLEEIGVPYELIQVDMSMTQEPEYKKLHPHGKVPILIDGEVTIFESAAICAYLADKYQTMGFAPAIDSPERGYYYQWLFYATATLEPPVEHFMFDVLPNLPEKILPIKARSAVSTQEALQWFDKVSLPLTELLSDKNYLVADKFSAADIVTGGVLLWAFKLGMLKDDSPLNRYIKRLMERPALMRADEDFVS
>NZ_AP018172.1|WP_096595327.1|4963441_4964179_-|hypothetical-protein
MLKPVKDPSTELATALLTHYSFDLSGYSASELIRRWKNQYPIEWLHIAVIEALYQGRYKAVSVQQILNFWHRRGQATYHFNMEFERLICSKFPESLTSIPTPVLYPAKKIATPVEKTNYHLASSSANPEPSPPKATRDYSQRALPPLKVVREAETQLASEDTQEIATSATHNAANTEPTQAESELQPSFQPESQLQANSPVYPASNRPQRLLPVGVNHRAIGQFTPEKSDRTESFASKLKAMSGG
>NZ_AP018172.1|WP_096590454.1|4964297_4966397_-|DUF1565-domain-containing-protein
MVNSTLVTTLYINSVQGNDANAGSRLSPFKSLTRALKASTKSTIIQLGPGTYSAATGEVFPLIIPAGVIVVGNEASKGAGIVIIGNGTYQSPSFGTQNITLMLQEDASLRGVTVTNTTSKGTGVWIESTAPTVSSNTFINCAREGVFTTGAAKPAILDNVFLQNAASGLTMARNSKGEVLRNVFQKNTLGIAISDSAAPLVANNKLSENQTAIALSRDARPVLRQNIITSNIQGGLLVNGNAIPDLGSTQDAAGNVFRDNKEYDLQNVTSQQLVSVGNQLNPILVKGAVDFLSATVESAGQVSVGTSFYDLGGHWAVAFVEALVSKNYLSGFPDGSFSPNSPITRAQYAAIIAKTFPPPNGSKVSNFTDVNPDYWAASAILRAANMGFISGFPDGTFRPGQNLTRIQAIVSIVNGLKWSGGNSNVLTVYRDRAQIPSYATNAVAIATQKLLVVNYPKTEQLEPLRDISRAEVAAIIYQALVAIGQEKAIPSPYIVNPDPDIASFSDLKGHWAETFIRALVSMGLTTGFADGSYQPDKPMTRAQYAALVAGAFNPTPQRPAIDFTDVAKDFWAAKAIQTAAMGGFVSGFSDRTFRPDQNVQRLQVIVSLVNGLALPAADNDNLLVYSDRNAIPEYARKAVATATQQQIAVNYPDPKQLVPVREATRAEVAAMVYQALVAIQRANAIKSPYIVSQITQLTK
>NZ_AP018172.1|WP_096590455.1|4966731_4967193_-|cupin-domain-containing-protein
MIINPENVPDRTTTLYPQEFKPLVMGRVKKAVGNAAGLKNFGVNLVTMAPGSRSSLRHWHTRQDEFIYIIEGEVTLVTNEGEQILQPGMMAGFPAGEANGHHLVNHSPETVIYLEIGDRTADDQAHYPDDDLMAQASANGWMFTRKDGTLYES
>NZ_AP018172.1|WP_096590456.1|4967182_4967620_-|GNAT-family-N-acetyltransferase
MTYQTVDQLTDNQIVELVDLYKNEFWSKKRTYQDVVKMLAASDIIIALVDDNKQLIGFTRILTDFVYRATVYDVIIKPTHRKMGLGAKLIDAAIHHPQLSEVEQIALYCLPEMIPFYQRWGFTNELSGMQLMYRYNLRSPKTNDY
>NZ_AP018172.1|WP_096590457.1|4967798_4968446_+|Uma2-family-endonuclease
MFALVSLEKIQLPSGSVVRLPATWQEYQILCQQRGDGSIPRIKYRDGEVLLMSPLPVHGRDANLLADIVKALLDDDRREYDAFTPVTMELPEESGIEPDYCFYIDDWQAISGKKRIDWQQDPPPDLVIEIDVTSYSDVQDYLPYRVPEVWLFKKQRLLIYQLQGDDYQLQTQSHYFPEFDLQNLIASCVKIAYERNTSAAIRHLKQQIFQVNKSI
>NZ_AP018172.1|WP_096590458.1|4968429_4969323_-|LysR-family-transcriptional-regulator
MKLSQLRAVVAVADCGNFSEAALELQLSQPAISHAIATLEEELGVPLFARGRHGAVLTPAGERILYHARQSLQHLEMMHKEANLHKGLHGGHVRIAAFRSVATHLLPKAIAQFHDQFPEVAVTIIESLSYIEVEQCLREGRADIGITYLPTSDEFEVWEIVRDEYVALLPPKAKVSSPTITWEDIAVYSPVLLSCLPCGRSLHNHLKNVASFMNTISDIQEDSTIVSLVNQGLRAAIIPRLAAVPIPQNVQVYSLPIPLERVMAVALLSNGLHIPAVFTFLEMLKKFDFYTLAKSTY
>NZ_AP018172.1|WP_096595328.1|4969536_4969773_+|hypothetical-protein
MKISSRTGNIFTSVCQALHSFWQNTMQTLLAPDELQVIQKVDRYGNIYWQAYDPVTGKSFSSGSEVDVSMWIEQLYRH
>NZ_AP018172.1|WP_096590459.1|4969781_4970450_+|glutathione-S-transferase-family-protein
MTQLTLVIGNKNYSSWSLRPWLALKQFGVQFDEIRIPLYTPETASKLQQYSPSGKVPALLHNNQTIWDSLAICEYLAEEFPHLHWWPEDKIARALARSISAEMHSGFQNLRQNMPMNCRAKLPGKGLTSEVQKDIDRITSIWQEFRQKFAADGDFLLGKFTIADAMFAPVVLRFVTYDVQLDSISQKYAETILELPAMQQWLEAAKNETEVLAQYEFYSNQN
>NZ_AP018172.1|WP_096590460.1|4970596_4971007_-|response-regulator
MPNKPISFKGLRLLVVDDDLDTRKLLTILFELDGAEVMAANSASEALEIISCFQPDVLISDICLPDEDGYSLLRKVKKIDLERGRKTPAIALSAYIMDEDRKYAYLAGYEKYLQKPINLDELAKAVIDLVKLRQCV

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Crispr_ID: NZ_AP018172_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_15

5282895-5283220

Orphan

Consensus_repeat	Method
GTTTCANTCCCCTTGCGGGGTAATAGNTAGTGGAAAC	CRT
AGTCCCCTTGCGGGGTAATAGTT	CRISPRCasFinder
GTTTCCACTAGCTATTACCCCGCAAGGGG-------ATTGAAAC	PILER-CR

4 spacers

The CRISPR arrays of NZ_AP018172_15

>merge|NZ_AP018172|15|5282895-5283220|CRT,CRISPRCasFinder,PILER-CR
TATTTAGTCCCCTTGCGGGGTAATAGTTAATGGTAACGGGAAAGGCGACAAGGAACGCGACGTGCTACTTCCGTTTCAGTCCCCTTGCGGGGTAATAGTTTGCGGAAACGATAAATACTTGGCTGCTAGTCAAAGAGTAGTGACGTTTCAATTCCCTTGCGGGGTAATAGCTAGTGGAAACTATGATCATTGGCAGTTAACAGTGGTTAATCATAAGTTTCAATCCCCTTGCGGGGTAATAGCTAGTGGAAACGAAAACTTAATCGGTTATAGTAGGCATCGCTAGCCAGTTTCAATCCCCTTGCGGGGTAATAGCTAGTGGAAAC

>NZ_AP018172|15|9|5282895-5283220|CRT
TATTTAGTCCCCTTGCGGGGTAATAGTTAATGGTAAC	GGGAAAGGCGACAAGGAACGCGACGTGCTACTTCC
GTTTCAGTCCCCTTGCGGGGTAATAGTTTGCGGAAAC	GATAAATACTTGGCTGCTAGTCAAAGAGTAGTGAC
GTTTCAATTCCCTTGCGGGGTAATAGCTAGTGGAAAC	TATGATCATTGGCAGTTAACAGTGGTTAATCATAA
GTTTCAATCCCCTTGCGGGGTAATAGCTAGTGGAAAC	GAAAACTTAATCGGTTATAGTAGGCATCGCTAGCCA
GTTTCAATCCCCTTGCGGGGTAATAGCTAGTGGAAAC

>NZ_AP018172|15|12|5282900-5283211|CRISPRCasFinder
AGTCCCCTTGCGGGGTAATAGTT	AATGGTAACGGGAAAGGCGACAAGGAACGCGACGTGCTACTTCCGTTTC
AGTCCCCTTGCGGGGTAATAGTT	TGCGGAAACGATAAATACTTGGCTGCTAGTCAAAGAGTAGTGACGTTTC
AATTCCCTTGCGGGGTAATAGCT	AGTGGAAACTATGATCATTGGCAGTTAACAGTGGTTAATCATAAGTTTC
AATCCCCTTGCGGGGTAATAGCT	AGTGGAAACGAAAACTTAATCGGTTATAGTAGGCATCGCTAGCCAGTTTC
AATCCCCTTGCGGGGTAATAGCT

>NZ_AP018172|15|9|5282967-5283220|PILER-CR
GTTTCAGTCCCCTTGCGGGGTAATAGTTTGCGGAAAC	GATAAATACTTGGCTGCTAGTCAAAGAGTAGTGAC
GTTTCAATTCCCTTGCGGGGTAATAGCTAGTGGAAAC	TATGATCATTGGCAGTTAACAGTGGTTAATCATAA
GTTTCAATCCCCTTGCGGGGTAATAGCTAGTGGAAAC	GAAAACTTAATCGGTTATAGTAGGCATCGCTAGCCA
GTTTCAATCCCCTTGCGGGGTAATAGCTAGTGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096590717.1\|5295426_5296152_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NZ_AP018172.1\|WP_096590707.1\|5282190_5282397_+\|antitoxin-family-protein	unknown	unknown	gnl\|CDD\|376681
NZ_AP018172.1\|WP_096590712.1\|5289259_5290546_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_AP018172.1\|WP_096590709.1\|5283676_5285038_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_AP018172.1\|WP_096590711.1\|5286237_5288466_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|106506
NZ_AP018172.1\|WP_096590701.1\|5271660_5275629_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|380161
NZ_AP018172.1\|WP_096590718.1\|5296710_5297796_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340832
NZ_AP018172.1\|WP_096590703.1\|5278296_5279433_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|225070
NZ_AP018172.1\|WP_096590702.1\|5276254_5278045_-\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NZ_AP018172.1\|WP_096590705.1\|5279917_5281267_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_AP018172.1\|WP_096590704.1\|5279538_5279850_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590708.1\|5282413_5282842_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|225266
NZ_AP018172.1\|WP_096590713.1\|5290593_5291949_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|236890
NZ_AP018172.1\|WP_096590714.1\|5292159_5292660_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP018172.1\|WP_096590706.1\|5281430_5282081_+\|transaldolase	unknown	unknown	gnl\|CDD\|188643
NZ_AP018172.1\|WP_096590710.1\|5285099_5286224_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|381089
NZ_AP018172.1\|WP_096590715.1\|5292830_5293034_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590700.1\|5270566_5271217_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NZ_AP018172.1\|WP_096590699.1\|5270141_5270546_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590716.1\|5293228_5295073_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|224182

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096590717.1\|5295426_5296152_-\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	8.88858e-83
NZ_AP018172.1\|WP_096590707.1\|5282190_5282397_+\|antitoxin-family-protein	gnl\|CDD\|376681	pfam01954, DUF104, Protein of unknown function DUF104. This family includes short archaebacterial proteins of unknown function. Archaeoglobus fulgidus has twelve copies of this protein, with several being clustered together in the genome.	0.0091271
NZ_AP018172.1\|WP_096590702.1\|5276254_5278045_-\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NZ_AP018172.1\|WP_096590712.1\|5289259_5290546_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.20174e-71
NZ_AP018172.1\|WP_096590709.1\|5283676_5285038_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	0
NZ_AP018172.1\|WP_096590711.1\|5286237_5288466_-\|PAS-domain-containing-protein	gnl\|CDD\|106506	PRK13560, PRK13560, hypothetical protein; Provisional.	7.68232e-70
NZ_AP018172.1\|WP_096590718.1\|5296710_5297796_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340832	cd03802, GT4_AviGT4-like, UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.	6.04125e-155
NZ_AP018172.1\|WP_096590703.1\|5278296_5279433_-\|amidohydrolase-family-protein	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	1.34558e-11
NZ_AP018172.1\|WP_096590710.1\|5285099_5286224_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|381089	cd17534, REC_DC-like, phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains. This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.01513e-57
NZ_AP018172.1\|WP_096590705.1\|5279917_5281267_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	6.16551e-119
NZ_AP018172.1\|WP_096590701.1\|5271660_5275629_+\|PAS-domain-S-box-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	1.10801e-64
NZ_AP018172.1\|WP_096590708.1\|5282413_5282842_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|225266	COG2402, COG2402, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	4.18343e-19
NZ_AP018172.1\|WP_096590713.1\|5290593_5291949_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|236890	PRK11274, glcF, glycolate oxidase subunit GlcF.	7.67354e-101
NZ_AP018172.1\|WP_096590714.1\|5292159_5292660_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.55966e-13
NZ_AP018172.1\|WP_096590706.1\|5281430_5282081_+\|transaldolase	gnl\|CDD\|188643	cd00956, Transaldolase_FSA, Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea. Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea, which are member of the MipB/TalC subfamily of class I aldolases. FSA catalyze an aldol cleavage of fructose 6-phosphate and do not utilize fructose, fructose 1-phosphate, fructose 1,6-phosphate, or dihydroxyacetone phosphate. The enzymes belong to the transaldolase family that serves in transfer reactions in the pentose phosphate cycle, and are more distantly related to fructose 1,6-bisphosphate aldolase.	1.50061e-65
NZ_AP018172.1\|WP_096590700.1\|5270566_5271217_-\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	7.43356e-71
NZ_AP018172.1\|WP_096590716.1\|5293228_5295073_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	5.72812e-85

>NZ_AP018172.1|WP_096590708.1|5282413_5282842_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MRSEVFLDTTFAIALAAPQDNLHRRAVHLAELLETAGTRLVTTQAVMLEIGNILAKQPLRHGAVTLLNALAADSKVEIVPLSQELYDRAFQLYCDRSEKEWRFIDCVSFIVMQYSGISEALTANEHFQQAGFRALLREELSY
>NZ_AP018172.1|WP_096590707.1|5282190_5282397_+|antitoxin-family-protein
MAEKITAVFDGRVFYPIESIALPANTRVRLSIEVLPPEKQESVSFLMTARSLNLSGPADWSTKIDKYL
>NZ_AP018172.1|WP_096590706.1|5281430_5282081_+|transaldolase
MSIYLDSAIIAEAQAAKEMGWVKGITTNPTLLAKSDLPVETTLKRLAQLTTGPVFYQLMSSDFDEMLAEGRAAFEIIGNQTVLKIPASLVGFQVVAALAGEISCAVTGIYYASQAAVAKEAGAKYAIAYVNRATRLLGDGVALIQQMASVVAGSSTEIMAASIKSPEEAVASLQAGAHHLTLPLPMLHAMATHELSLQTIDEFAKHGRGIWVSCKL
>NZ_AP018172.1|WP_096590705.1|5279917_5281267_-|glutamine-synthetase
MAEHYTYKKVKKSLHEAGVKFVRILWCDNANIIRGKAVHLDMLSHYFEHGVGISAGEQGIPVMYDAIVPNSGLAPVGEIRLVPDWSSLTPIPYAPGHARVLGNMVLDGKPWAFCPRNFLIQMIAAAKREGLEIQAAFENEFYLLRQTSEGIVPTDSTVFASTQSMDINREVIDAIADALIAQGIPVEQYYPESGPGQQEISMRYTDALQAANWQIGFRETVRAIARHHHLTASFLPKIFPDAASSGCHIHLSLWRDGQNLLPDPQGVCGLSQIARAFIAGILDHLPALMALTTPSPNSYRRIRPHTWSAAFRCWGLDNREAAVRVPSDPGLQSSSHFEVKTVDASANPFLALGAIIAAGLDGVQRGLEPPNPVAEDPGHLSIEQRKANSIDALPTNLGEALGYFQQNKVLLNALNPQLSQAFLAVRQAEWEAMKDWELDAEVKLLLERY
>NZ_AP018172.1|WP_096590704.1|5279538_5279850_+|hypothetical-protein
MEFEPLSLEVEPLNLEVAPLSLEAAPFCLEVEPLSLKVAPLSLEVAPLSLNVEPFCLEVAPLSLNVEPFCLKVAFLSLEVAPLNLEVAPLNLKATTLSLKVAP
>NZ_AP018172.1|WP_096590703.1|5278296_5279433_-|amidohydrolase-family-protein
MRLDLADIPLIDQHAHNILRPEVAARYPYAAAFTEGYDEEIVNNHARHTLFYRRSLREIAALLECDAQENAIAARRQELGLENLTQLYFRTANLEAIYLDDGLEVESILPLSWHEKLIPVQRILRLEVIAEQLIPQIADFKTFLARFTSEIDPPPPGVVGFKSIVCYRTGLDVQPVTFEVAASRFYEIKQQLTNQPLRLVDKSLIDFLLQQALLIAAKHQLPLQLHTGFGDPDLDLRLANPLHLRSLLELPQYRHAPIVLLHAAYPYMREAGYLASVYPQVYLDYGLAVPSLSVSGMREAIRQLLELAPTSKLMYSSDAHSIPELYYLGAKWGRQLLAEVLDQAIEDTDLTVKEAEAIATAILRENAISLYLKKEHRA
>NZ_AP018172.1|WP_096590702.1|5276254_5278045_-|translational-GTPase-TypA
MTLPIRNVAIIAHVDHGKTTLVDALLKQSGIFREGEDVPDCVMDSNALERERGITILSKNTAVRYKETLINIVDTPGHADFGGEVERVLGMVDGCILIVDANEGPMPQTRFVLKKALEKGLRPIVVVNKIDRPQADPYGAIDKVLDLFLELGADEDQCDFPYLFASGLAGYAKDDLDAEAVDMQPLFEAILRHVPPPVGDINKPLQLQVTTLDYSEYLGRIVIGRIHNGVIRAGQQAALVTENGSIVKAKITKLMGFEGLKRVDMEEASAGYIVAVAGFADANIGETITDPNEPQALPLIKVDEPTLQMTFWVNDSPFAGQEGKLVTSRQVRDRLLRELETNVALRVEETDSPDKFLVSGRGELHLGILIETMRREGYEFQVSQPQVIYREVNGQPCEPYELLVLDVPADAVGSCIERLGQRKGEMQDMQPGGNDRTQLEFVIPARGLIGFRGEFMRMTRGEGIMNHSFLDYRQLSGDIEARNKGVLISFEEGVSTFYAMRNAEDRGVFFITPGTKVYRGMIVGEHNRPQDLELNICKTKQLTNHRAAGGDELVQLQAPVDMSLERALEYIGPDELVEVTPQSIRLRKMAKKLAKR
>NZ_AP018172.1|WP_096590701.1|5271660_5275629_+|PAS-domain-S-box-protein
MRLYSRLLPYGVAIGSTAIALLLKLSLERLLPEIFGGFFYIAILISTWYGGSLPGIVTVVLSALAIEYFFLYPRYQFWLFQPQNVLQLSVFLLIALVINRLTSNFLNSKQKILQLNQKLAQENAEQLRMALGAAQMGMWDWDMVTGEIKWSPEHEQLFGMAVGTFDGKYETFAAYLHPDDRESVDRAIQRALKTHSSYQHEYRIIWVDGSIHWLEGRGQAFYDAADRPVRMTGTIAAIDQHKQTQAALQQQFEQQRLVMEITQRIRRSLNLPEILQTTVDEVRQFLNCDRVIIFQFSADWSGTVVVESVGANWTAILSTNIYDPCFSESYIQPFKEGLVTAKSDIYRAEINPCHLELLANFQVKANLAVPILNKDELWGLLIAHHCTDPYEWQSSEIELLRQLGAQVSIAIQQADLFAQVQTELKERQQAQEALQQSEHRYRALVHASAQIVWRTDADGMTIVAPEVWEQLSGQSTAESLGLGWLNFVHPEDRDRALQCWQESYTNLTLFETEYRLRMKDGNYRDFAVRGLPIPDADGISEWIGTCTDITERKQAEKELKQAKEELEIRVAERTLELTEVNDRLLAVLMQQHQARQVLEEQAQLLDLAHDTIITRDFNGAISFWNKGAEQMYGWKKSEALGQILHTLLKTQYPQPLAEIEAELLEKGYWEGELIHFCRDAQPINLASRWVLQKDCAGRPIKILEINNDITERKLAEAALQQYVHEVEDLYNNAPCGYHSLNAEGNLIRINDTELKWLGYTRDEILHKNFSDFVTSEAKQIFQENFPKLKQQGWLNNLEFEIVNKDGRTRWVSLNATAIKDEAGNFVMSRSMLFDISHRKQAEKMLELQAVITRNMAEGICLVRTDNAVIVYANPKFEQMFGYDSGELNGQHVSILNYAHESVTAEDVNQAIRSAVLQQGEATYEVHNVKKDGTPFWCSATTSVFSHPDYGDVLVAVHQDITERKRIEDALRQSEEKFRQLAENIQAVFWMTDIHTRQVLYVSKAYETIWQRSCQSVYQNFSDWLDAIHPDDRSRVDLAFSQQLKTGQSDTKYRIIRPDGSMRWIRDRAFPIENERGEIIRVGGIAEDITELQKVEQIKSEFISIVSHELRTPLTAIRAALGLLNSGIYDQKPEKSKQMIEVAAVESERLVRLVNDILDLERLESGRSVLKKTTCEAADLIQQAVAGVKAIAKQQNISFDIHPTNAQVWAAADAIIQTLTNLLSNALKFSPPNSTITISVEQQTDRVQFQIRDRGRGIPADKLELIFGRFQQVDASDSRDKGGTGLGLAICRSIINQHSGKIWAESTLGAGSTFFFTLPLVEK
>NZ_AP018172.1|WP_096590700.1|5270566_5271217_-|hypothetical-protein
MSSTKIMTNILLFRWRNILQPFGIEPRLIDRAFKQVIDAYSTPNRYYHTLKHIEHILATIDSLQTYTQDLISVQLAAWLHDIVYDTRAQDNEEKSAEYADDLLSNLGLPINNIATVKRLILNTKQHQTTADDWDGKVLLDADLAILAVNSIQYQEYAQAIRQEYAWVPEAEYIKGRRQILERFLQRQRLYFTPLMLEVAEASARANLQAEIKILNV
>NZ_AP018172.1|WP_096590699.1|5270141_5270546_+|hypothetical-protein
MTKVVMFLITAYSFIDNIKAFINNMLMFFITAYSFIDNIKAFINNMLMFFITAYSFIDNIKAFINNMLMFSINLNSFIYNIKVLATKVLTFLITVNLFIDIIKGASHFFNQYPFSRVGIAHYIQVLVGQYLPYT
>NZ_AP018172.1|WP_096590709.1|5283676_5285038_+|NAD(P)/FAD-dependent-oxidoreductase
MVNLLDNNPHHQVVIVGGGFGGLYAAKALAKAPVNVTLIDKRNFHLFQPLLYQVATGTLSPADISSPLRSVLSKSKNTKVLLGSVNDIDPEAQTVQVEGEAIPYDTLIVATGAKHSYFGKDNWEEFAPGLKTVEDAIEMRRRIFTAFEAAEREKDPVKRRAWLTFVIVGGGPTGVELAGAIAELAYQTLTEDFRNIDTSEARILLLEGMDRILPPFDPELSQAAEKSLKELGVIVQTKTLVTNIEDDIVTLKQGDGLREIASKTILWAAGVKASPMGKVLAERTGVELDRAGRVIVESDLSIKGYDNIFVVGDLANFSHQDGKPLPGVAPVAKQEGEYVAKLIEQRIQGNILPPFNYINRGSLAMIGQNLAVVDLGFIKLRGFFAWLFWLLVHIYFLIEFDNKLIVMVQWVWNYITRNRGARLITGGESLALTGLDDSHSYYSSEETRQAVNV
>NZ_AP018172.1|WP_096590710.1|5285099_5286224_-|hybrid-sensor-histidine-kinase/response-regulator
MKEKILVVENEIIIAYDIKTCLEKAGYIVPAIAAYGEQAIAKAAELSPDLVLMDVMLKGEMSGIEAAAEIGTRFNIPVVYLTAYSDQSNLQKAKTTQPFGYILKPFEETQLITTIEIALNKHQTEVVMRKALEKEKEDQKIKNQFFSMISHEFRNPLSNIFTCTELLTDRSHQLTEAKKDEYLNHIQNSVQHLEHLLGDVLLIGKAETGKIQFNPEPLDIEKFCQNLIADVKLTASENHNIIFTVQGSSASKENTITKQTSQAIGLDEKMLRHILINLLTNAVKYSPQGGTINLELFYVPGEVIFRLQDEGIGIPEADQENLFNSFHRCSNVGNIPGNGLGLAIVKHYVELHGGEISFASKPGIGTTFIVNLPI
>NZ_AP018172.1|WP_096590711.1|5286237_5288466_-|PAS-domain-containing-protein
MPVLNYVTQDYILTFAPHTPLKEILIYLGQAGENIDIDNGSFVDAHTLHTYRSQVQVIAGKSPPSFNHLGASKRTSPINQIAQPIDCIYVVDKLQLLGIVTLTDAIRLINSGINLSVVKLADVMKEPVITLERDFDVNKTLSLIHEYGIRHLPIVNDRGQLLGIVTPESLALGLQKELTKIKENLQLEIAQRCSLEMSLKKAEDESERLIAQATNELIITNNELQREIRDRQHIEEALRYRVEFEKLITAISTHFINLAPDEIENGINQALQLIGEVTNVDCAYVFVFDEDSKIDNTYKWYAEGIEKQINNLQDIRDIVFLWGKEKLSNFETIHIPNVDDLLLPVSTKNLRSLIIVPIICSGLLIGYLEFDSIKTPKNWTEDSITMLKMVGEILGNALERKRVEQALRISEERYIRAISAGKVGIWELNTKTNEIYIDPNLLAMLGYTEEETPQYYDDWLKFVHPDDVDYVKNALNQYLAGITPKYEIEHRMLNKDGSCIWFLSRATLLCKSQNNECFLAGSNTDITARTQVENKLKVSLKEKEILLKEIHHRVKNNLQIISSLLRLQTRYINDGETLEIFQDSHNRVRAMAIIHENLYQSHDLTKIEFCDYARSLTNNLLRSYGVKSNIKIDLNINNISLKIDTAISCGLIINELVTNSIKHAFVNKNSGDIHIELIETAKNQYSLVVSDNGVGLSKDIEIYKNQSLGLKLVWSLVEQLEGMITFNTSLGTSFTITFKEQN
>NZ_AP018172.1|WP_096590712.1|5289259_5290546_+|FAD-binding-oxidoreductase
MNAIASSLASIVNEENAVYLWENLEPTRKESIQKAMAAGKYPSCIVYPRTQEQLAAIIAEAHRQNWRVLPCGSTSKLSWGGLACDIDVVVSTERINQLIEHAVGDLTITVEAGMKFADIQGILAKYRQFLALDPTAPELATIGGIVATANTGSLRQRYGSVRDQLLGITFVRADGQIAKAGGRVVKNVAGYDLMKLFTGSYGSLGIITQVTFRVYPQQEASATVVLTGTAEAMSDAAATLRGSALTPTQADLLSNKLVSSLGLGTGLGLIARFQSISESVNEQANRLLEVGKQLDLAGTIYVAQDETNLWQRLPEQIQSSATDFPITCKIGVLPSAAVEVLNQVEIGFIHISSGLGALSLNSQKQTLKMREICQTHSGFLSILEAPATVKEKFDVWGYTGNALDLMRRIKAQFDSKNILSPGRFVGGI
>NZ_AP018172.1|WP_096590713.1|5290593_5291949_+|4Fe-4S-dicluster-domain-containing-protein
MQVSENSVNNTASLKNLKGFDENHPPDPKLIDSCVHCGFCLSTCPSYRVLGKEMDSPRGRVYLMDAINEGEIALNTATVEHFDSCLGCLACVTTCPSGVQYDKLISATRHQVERNYTRSLPDQLVRKLIFSLFPNPDILRMLLVPLMAYQKLGFSKFVRATGLLKNISPRLAAMESILPEITLKTFQNNLPTVIPAKGEKRYRVGMILGCVQRLFFSPVNEATVRVLTANGCEVVIPRSQGCCAALPEHQGQTEQAKALARQMIDSFAKTDVDFVIINAAGCGHTLKEYGHILENDPEYREKAKEFAAKVKDAQEFLATVGLTAKLLPITDKPLNLVYQDACHLLHGQKISVQPRQLLRQIPGVKLKEPLDAALCCGSAGVYNMLQPEVAEELGQQKVQNLLNTGADLIASANPGCTLQITKHLHLQGKNISVIHPMELLDYSIRGVKLAV
>NZ_AP018172.1|WP_096590714.1|5292159_5292660_-|GNAT-family-N-acetyltransferase
MQNAENPAKNSLEIIQTTDLIDFIPVLKELEFGDTFKLAMLKWCGMGDRDRSIGFWQVYLAKLEAETIGVMGLYQLVDSPSEVVWVGWFGIRPKFRRQGWGRIIINQLKEYAREFEFQQLWVYTDNPNLAAISFYENCEFVKLGVAKDICPGKTHSLSDIIMMFNL
>NZ_AP018172.1|WP_096590715.1|5292830_5293034_-|hypothetical-protein
MTVVVAVVAVLIALATLILVFVAVSLAVVNVVVAVVNFSLAFATLKAAIVNNFSKFTGFIIELVRVL
>NZ_AP018172.1|WP_096590716.1|5293228_5295073_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MQICQNPNCSNPFNHDGNRFCVSCGHSNFGKLLRNRYRVLRLLGEGGFSRTYAAEDVDRLDAPCVIKQFFPQVQGTGQRQKAAEFFKEEAFRLYELGENHTQIPRLLAYFEQGSSLYLVQEFIQGKTLLQEVQGQCFTEQEIRQLLADLLPVLDFIHSHNVIHRDIKPENIIRRDSDGKPVLIDFGGAKQVTQTSLARQATVIYTIGYAPTEQMAGFACHASDLYALGVTCVRLLTQCLPLQNSDGQIEDHLYDAMSAKWLWPERLQKNGIKISDGLAKILDKLLQHLPKDRYQSAAEVLDDLKSTTTSELEAEILAISQQILLPVSTPTRPQKDIKPLPSLQSFEFDVVTVDTAGREVNRDRRYGKYFIEELNKAIALEMVSIPGGTFLMGSPEFEGDADERPQHKVRVAPFFMGKYPVTQAQWKAVAALPKVKQALNPNPSKNKGPVRPVENVSWHEAVEFCLRLAEITGRDYRLPSEAEWEYACRAGTKTSFHFGETITSDFVSCSNSDTKTRKETTNVGSFEVANAFGLYDMHGLVWEWCADPWHNNYHGAPTDGSIWEEGGDIHRRVLRGGSWSFGAELCRSASRSWNESDGGLRICGFRVVFSAEGML
>NZ_AP018172.1|WP_096590717.1|5295426_5296152_-|ABC-transporter-permease
MYLPILVLAFYSFNKSPYSASWQGFTLDWYRQLFSDERIVSALWNSLIVAFSAVAISAVLGTLMAVGLARYQFPLKKLYRGVSYLPLIIPDIAIAVATLVFLAAFAIPLSLWTIIAAHVVFCLAYVALVVSSRLSHLNPHLEEAALDLGATPVQAFIKVLLPQLMPGIIAGCLLAFVLSLDDFLIASFTAGSGSNTLPMEIFSRIRTGVKPDINALSVILILVSGIVAFVAELIRAYGDEI
>NZ_AP018172.1|WP_096590718.1|5296710_5297796_+|glycosyltransferase-family-4-protein
MRIAQIAPLWERVPPPGYGGIELVVGLLTDELVRRGHEVTLFASGDSISLAELESVHPRALRLDPNVKEYGIYEMLQLGSVYGRAEEFDIIHSHMGCAALPYANLVKTPTVHTLHGIFTPDNEKMFKFAKHQPYISISDAQREARLGLNYVATAYNGIDVSSYQFHPKPTDPPYLAFLGRISPEKGTHLAIAIAKKAGWHLKIAGKVDVVDVEYYEKEVKPLIDGKQIEYLGEANHEQKNALMGGAVATLFPITWREPFGLVMVESMASGTPVIAMKLGSTVEVIDHGKTGFLCENIQEFVTAINKVTELDRHACRKYVENRFSFQKMTDSYEEAYRQILQKRFAQNGRSHSVAGLSKSLI

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Crispr_ID: NZ_AP018172_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_16

5529936-5530075

Orphan

Consensus_repeat	Method
GCTATGGGAGTTGGTGGTGCTATTGGTGGTGTAGCATTTGGTGTAGCAGATGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018172_16

>merge|NZ_AP018172|16|5529936-5530075|CRISPRCasFinder
GCTATGGGAGTTGGTGGTGCTATTGGTGGTGTAGCATTTGGTGTAGCAGATGGTGCTGTCCAAACTGGGCAAGCTGTTGCTGGGGCTGCTATGGGAGTTGGTGGTGCTATTGGTGGTGTAGCATTCGGTGTAGCAGATGG

>NZ_AP018172|16|13|5529936-5530075|CRISPRCasFinder
GCTATGGGAGTTGGTGGTGCTATTGGTGGTGTAGCATTTGGTGTAGCAGATGG	TGCTGTCCAAACTGGGCAAGCTGTTGCTGGGGCT
GCTATGGGAGTTGGTGGTGCTATTGGTGGTGTAGCATTCGGTGTAGCAGATGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096590978.1\|5539054_5539450_-\|DUF1830-domain-containing-protein	unknown	unknown	gnl\|CDD\|370162
NZ_AP018172.1\|WP_096590968.1\|5535281_5535536_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590982.1\|5542014_5543406_+\|metal-dependent-phosphohydrolase	unknown	unknown	gnl\|CDD\|226701
NZ_AP018172.1\|WP_096590954.1\|5525286_5525850_+\|DUF4126-domain-containing-protein	unknown	unknown	gnl\|CDD\|379253
NZ_AP018172.1\|WP_096590976.1\|5538450_5538912_-\|DUF4079-domain-containing-protein	unknown	unknown	gnl\|CDD\|372553
NZ_AP018172.1\|WP_096590964.1\|5531613_5533140_+\|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-subunit-B	unknown	unknown	gnl\|CDD\|214355
NZ_AP018172.1\|WP_096590942.1\|5517132_5518011_+\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NZ_AP018172.1\|WP_096590970.1\|5536089_5536860_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP018172.1\|WP_096590972.1\|5536933_5537716_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224058
NZ_AP018172.1\|WP_096590974.1\|5537771_5538305_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096590966.1\|5533280_5534615_-\|NACHT-domain-containing-protein	unknown	unknown	gnl\|CDD\|366375
NZ_AP018172.1\|WP_096590958.1\|5527054_5528218_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|178068
NZ_AP018172.1\|WP_096590952.1\|5523757_5525053_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|180954
NZ_AP018172.1\|WP_096590956.1\|5525918_5526968_-\|WD40-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018172.1\|WP_096590946.1\|5519119_5521291_-\|polyphosphate-kinase-1	unknown	unknown	gnl\|CDD\|235469
NZ_AP018172.1\|WP_096590980.1\|5540026_5541616_+\|B12-binding-domain-containing-radical-SAM-protein	unknown	unknown	gnl\|CDD\|223963
NZ_AP018172.1\|WP_096590944.1\|5518135_5519116_+\|magnesium-transporter-CorA	unknown	unknown	gnl\|CDD\|213362
NZ_AP018172.1\|WP_096590950.1\|5523165_5523717_+\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NZ_AP018172.1\|WP_096590960.1\|5528311_5528935_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_AP018172.1\|WP_096590948.1\|5521572_5522616_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096590978.1\|5539054_5539450_-\|DUF1830-domain-containing-protein	gnl\|CDD\|370162	pfam08865, DUF1830, Domain of unknown function (DUF1830). This family of short proteins is functionally uncharacterized.	6.10221e-45
NZ_AP018172.1\|WP_096590982.1\|5542014_5543406_+\|metal-dependent-phosphohydrolase	gnl\|CDD\|226701	COG4250, COG4250, Predicted sensor protein/domain [Signal transduction mechanisms].	5.05374e-76
NZ_AP018172.1\|WP_096590954.1\|5525286_5525850_+\|DUF4126-domain-containing-protein	gnl\|CDD\|379253	pfam13548, DUF4126, Domain of unknown function (DUF4126).	2.61569e-30
NZ_AP018172.1\|WP_096590976.1\|5538450_5538912_-\|DUF4079-domain-containing-protein	gnl\|CDD\|372553	pfam13301, DUF4079, Protein of unknown function (DUF4079). This is an uncharacterized family of proteins.	2.39911e-35
NZ_AP018172.1\|WP_096590964.1\|5531613_5533140_+\|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-subunit-B	gnl\|CDD\|214355	CHL00076, chlB, photochlorophyllide reductase subunit B.	0
NZ_AP018172.1\|WP_096590942.1\|5517132_5518011_+\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	2.58247e-107
NZ_AP018172.1\|WP_096590970.1\|5536089_5536860_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.44374e-74
NZ_AP018172.1\|WP_096590972.1\|5536933_5537716_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	9.23912e-75
NZ_AP018172.1\|WP_096590980.1\|5540026_5541616_+\|B12-binding-domain-containing-radical-SAM-protein	gnl\|CDD\|223963	COG1032, COG1032, Fe-S oxidoreductase [Energy production and conversion].	2.80824e-60
NZ_AP018172.1\|WP_096590966.1\|5533280_5534615_-\|NACHT-domain-containing-protein	gnl\|CDD\|366375	pfam00931, NB-ARC, NB-ARC domain.	3.55978e-07
NZ_AP018172.1\|WP_096590958.1\|5527054_5528218_-\|ferrochelatase	gnl\|CDD\|178068	PLN02449, PLN02449, ferrochelatase.	0
NZ_AP018172.1\|WP_096590952.1\|5523757_5525053_+\|adenylosuccinate-lyase	gnl\|CDD\|180954	PRK07380, PRK07380, adenylosuccinate lyase; Provisional.	0
NZ_AP018172.1\|WP_096590956.1\|5525918_5526968_-\|WD40-repeat-domain-containing-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.23495e-69
NZ_AP018172.1\|WP_096590946.1\|5519119_5521291_-\|polyphosphate-kinase-1	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NZ_AP018172.1\|WP_096590944.1\|5518135_5519116_+\|magnesium-transporter-CorA	gnl\|CDD\|213362	cd12828, TmCorA-like_1, Thermotoga maritima CorA_like subfamily. This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	4.62944e-55
NZ_AP018172.1\|WP_096590950.1\|5523165_5523717_+\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	4.17456e-46
NZ_AP018172.1\|WP_096590960.1\|5528311_5528935_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.80085e-28
NZ_AP018172.1\|WP_096590948.1\|5521572_5522616_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.64832e-63

>NZ_AP018172.1|WP_096590960.1|5528311_5528935_+|class-I-SAM-dependent-methyltransferase
MATILRDWSYRYQWLYDGISGLAALSVGGETRFRQLALQGLTINSDTKILDLCCGSGQATQFLVKYSQNVTGLDASPLSLKRAKQNVPSATYVEAFAENMPFTDSEFDVVHTSVALHEMEPEQLRQIINEVYRVLKPGGVFALVDFHAPTNPIFWPGVSLFLLLFETETAWQLLKTDLPAVLAETGFEVSEPKLYAGGSLQVIQAKK
>NZ_AP018172.1|WP_096590958.1|5527054_5528218_-|ferrochelatase
MGRVGVLLLNLGGPDKLEDVGPFLFNLFSDPEIIRLPFRSLQRPLAWFIASRRTKTSQENYKQIGGGSPLRRITEAQGEALKQQLQDLGQEANIYVGMRYWHPYTEEAIALVAQDNIERLVILPLYPQFSISTSGSSFRLLEKLWQENPKLQPLEYTVIPSWYKQPSYLQAMAELIAQELDRFPNPDEVHIFFSAHGVPKSYVEEAGDPYQQEIEECTVLIMRTLNRPNAHTLAYQSRVGPVEWLQPYTEDALKELGAKGVKDIVVVPISFVSEHIETLQEIDIEYREIAEEAGIHNFRRVPAPNTHPVFIRALADLVIDALTKPNFKLSQAAQMKKKVKMYPQERWEWGITTSAEVWNGRIAMLGFIALIIELVTGRGLLHMIGLL
>NZ_AP018172.1|WP_096590956.1|5525918_5526968_-|WD40-repeat-domain-containing-protein
MTLNHIPWKAITVLTLTVVTTAVCGCNTFTSKTQDLITQSSQNSQLLRKLSTDSDSGYSVAYSPEVSRANNPVGSTLASAGAKTVKLWNPSTGKVIRTFTGQAWAVNFSPDGQILASGSQNGTLSLWNVSTGELIRTLKHSEPVIDVVFSPDGQTLASGLDGGANIRLWNWRTGEIIRIPDDFNASRRGFDNFKSVPIAFSPDGQTFFARSGSGQASQLWNVSTGKVLSSFDAKSLINDIAITPDGKTLAAGIRDNAIKLWNVNSGKLIHTLTGHTGEVRTVAFSLDGKTLASGSQDGTIKLWNVKTGKIISTFKAQTEKVWSVAFNPDGKTFASGSQDGTIKIWQIPQ
>NZ_AP018172.1|WP_096590954.1|5525286_5525850_+|DUF4126-domain-containing-protein
MIDILATLSASAAAGIRIGIPLLIIGFLHGGYLWSKVPILSHISSPVLLAFFSIWSVVELVASKKRLGQRVLQIFELLLSPIVGAIMGLTVASTTIGPNWLIAVIGGLLALVFQLVQVGWFYRLRGLPLWAVFLQDFLCVVLVLFAFKAPWPGGLITLILLWFAIRSAKEWYDWYWQYRRRQSKAKS
>NZ_AP018172.1|WP_096590952.1|5523757_5525053_+|adenylosuccinate-lyase
MIERYTLPEMGNLWSEAYKLKTWLQVEIAVCEAQAELGYIPSDAVEEIKAKANFDPKRVLEIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLDVLLQRLEDLIQAIRQKAKEHRYTVMIGRSHGIHAEPITFGFKLAGWLAEVLRHQERLQTLRKTIAVGKISGAVGTYANIEPRVEAIACQKLGLKPDTASTQVISRDIHADYVQQLALVAASIERFAVEIRNLQKTDVLEVEEFFAKGQKGSSAMPHKRNPIRSERLTGMARLVRSHAGAALEDIALWHERDISHSSVERVILPDACILTHFMLVEIADLVTNLLVYPENMQRNLNCYGGVVFSQKVLLALVEKGISREEAYAIVQTNAHAAWNKPDGNFHDLITKDPRVTEKLTPAEIELCFDPQQHLRHLEQVYQRLGI
>NZ_AP018172.1|WP_096590950.1|5523165_5523717_+|DUF421-domain-containing-protein
MDKWFYINWRAIFVPSISVLELVIRGSLVYLALFSVLRLLPSRQMGTLGITDLLVVVLFAEAAQNAMASNYTSITEGAILVGTVIFWSYLLNWLGYKLPQFQRFLNPPPLLLVKNGRIIHRHLERELITEDELMSKLRQQSIEYLEDVKLAFMEADGSISVITSESKTSSIAKQETKSKSDLP
>NZ_AP018172.1|WP_096590948.1|5521572_5522616_-|serine/threonine-protein-kinase
MNRFSPQIRHLHECIQQTQLGRMCGSSERFRDRYEILRILGRGGFGITFLAKNAVLPGKPLCVIKQLCPKVTSLNSWQRACQRFEKEAKALGALGNHPQIPMLLDYFEVKGEFYLVQEYVRGSTLAREVRKSGPKNEAAVKQFLQELLPVLQYLHQHHVIHRDIKPHNLLRCEDHQRFVLIDFGAVKEELADACEHSISDRATTNFVGTMGFAPPEQFSLRPVYASDIYALGVTCLYLLTGKGPLEFDYDPDTGEILWQKEVTVSDNFAQILGKMVKIPLKERFKTAKDVMTALDLESYVPSLTNCLTTQPRRVKTPIKEEIPQTYIPSIKRTAIAIREWKAKLQGK
>NZ_AP018172.1|WP_096590946.1|5519119_5521291_-|polyphosphate-kinase-1
MSKTKKANKDINLNDSQYYLNRELSWLEFNRRVLHEALDRRTPLLERLKFTAIFSSNLDEFFMVRVAILKEQVEAQLSQQTIDGLTPQQQLEAIYQCLHPMVIEQHRYFEQVLRPEMASHGIHLLNYIDLSPEQRSYLQQIFQKKIFPVLTPLAVDPSHPFPLMANLSLNLAVVVKAPNTGEEKFARVKVPNILPRFIALPQELQLQNGKLNHWTGVAIEQIIAHNLEALFPGMIIKEYHLFRLTRDADLEVAEDEADDLLLAIQQELRKRHFGGSVVRLEIQPSMPFSVRQMLITEMDLAESDIYEIDGLLNLKDLISFIKLPLPELKDPTWKPVIPPRLRHFHQPSKIANIDGQENNIFSVIQQKDLLVHHPYESFSCSVELFIAQAARDPHVLAIKMTLYRTTGDSELIGSLITAAESGKQVAVIVELKARFDEENNITWANKLEKSGVHVIYGLVGLKTHTKIVLVVRQEGENMRRYVHIGTGNYNAKTANLYTDVGLLSCREDLGADLTDLFNYLTGYSCQESYRKLFVSPVNMRDRIIALIHREIAHCKNGNRGHIIAKMNSLVDAQIIAALYEASQAGVKIDLIVRGICCLRPGIPEVSENIRVISIIGRFLEHSRIFYFNNNEQNEVYIGSADWMPRNLDRRVEAVTPIEDAEIVQNLQNILAIMLEDNQQAWELQSDGSYIQRRPHQDEPELSSQNILMDKTQQLSNNQLFSKL
>NZ_AP018172.1|WP_096590944.1|5518135_5519116_+|magnesium-transporter-CorA
MLILLTFSQNHLEVFTSWDVNAVLERIGSSDNIWLRCIQFRDRTAIGKIIKHFGLKPSRVDMIFNHCQMGIDDDIEDCLFDNYEILTHQKQNREFEVARGTIIVGNNFIITFEITEVKILSTLSINIQKRNINIQHLGIDYLFYLIFKDILNNYYTVFDHISRQLDDLEDEVLANSGDESTYQKIAAMRQSTRFGRRNFQSIKSLLAMMNYEDFQWLSPPVKELFNQDLVHDADKLWQEYQSLRVWMSELMEIQRDNVASKTSERINRLTILSTVFLPITFIAGVYGMNFKYMPELDQPWAYPTVMGVMVLIVIGSIIYAKQQRWL
>NZ_AP018172.1|WP_096590942.1|5517132_5518011_+|SMP-30/gluconolactonase/LRE-family-protein
MNLAQSSPKNILELRARLGEGPCWHQDEQLLYWVDIYNHRVHQFNPTTTAHKIFDVGEVVGCIAPAGTNRLIMAQRRRLAFLDTSNGKVTPILTLEDIEPDIRLNDGKCDAVGRFWFGSMSTSGTNGCLYRYDPNGSLHVLETGLTISNGLGWSPDNRTFYLTDSPLKTIYAFDFDAESGSISNRRVFIDLSAESFYPDGLAIDREGCIWSAMWDGWCIIRFDPAGKEMMRVMMPVQRPTACTFGNADLMTLYITTASVGLSEAEIQNSFYSGDLFSLTTPISGLPTHPFKG
>NZ_AP018172.1|WP_096590964.1|5531613_5533140_+|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-subunit-B
MKLAYWMYAGPAHIGTLRIASSFKNVHAIMHAPLGDDYFNVMRSMLSRERDFTPVTASVVDRNVLARGSQEKVVDNITRKDAEERPDLIVLTPTCTSSILQEDLHNFVERAQLEAKGDVMLADVNHYRYNELQAADRTLHQIVQFYIEKARKKGELPEGKTAKPSVNIIGISTLGFHHQHDCTELKKLMADLGIEVNTVIPEGASVNELKKMPQAWFNLVPYRELGLQAARYLEAEFGTPYVDITPMGVVETARCIRKIQQVINAQGAHVDYEEFINEQTLYVSQAAWFSRSIDCQNLTGKKAVVFGDNTHAAAITKILSREMGIHVVWAGTYCKYDADWFREQVSEYCDEVLITDDHGEIGDAIARVEPSAIFGTQMERHVGKRLDIPCGVIAAPIHVQNFPIGYKPFLGYEGTNQITDLIYNSFTLGMEDHLLEIFGGHDTKEVITKGISAESDLNWTKDGLAELNKIPGFVRGKVKRNTEKFARDRGIKDINSEVLYAAKEAVGA
>NZ_AP018172.1|WP_096590966.1|5533280_5534615_-|NACHT-domain-containing-protein
MLVLDRVLQKKHLSNIQELVLRLCWQGYTYAEIAESSGYDDDYIRDVGFRLWQTLSKALGENIAKSNVKTVLRRYYSNLLQAESQLSTTPGFAIPDTPQKKQDWGEAIDVSMFYGRTEEQALLREWIVEEKCRLVMLLGIGGIGKTALSVKVAEQLQSQFDLVIWRSLRNSPPIFELMRELISFCSQQTEVNLSDTIESQISCLIKYLRSQRCLILLDNLESILQSGKISGHYCAGYEGYGQLLRRIGDEVHQSCLLFTSRETPSGFTAREGETLPVRSLQLNGLSQLESQQILAAKGLVDSTVECDKLIQRYRGNPLALKIVATAIQYLFDGNISQFLQHSPVVFGELWEILEQQFHRLSANEKQVMYSLAVKQDWVTLKELQQCIISQISERELLEALLSLQKRSLIEQQSGNYTQQPVVMEYITDKLIGQVCCDIPTEDID
>NZ_AP018172.1|WP_096590968.1|5535281_5535536_-|hypothetical-protein
MLQDAQTIRYYQRITDAFVELWNRGYRMDDMRMYLDGYLAALRHGNAIEPYLIHRLEEEASRYLYDASNFAMTQPEPEPQHDYY
>NZ_AP018172.1|WP_096590970.1|5536089_5536860_+|response-regulator-transcription-factor
MGSVCIEIVEGNPHLRSLLGWHLQQLEYRVHQAASIYQAREVFLSQQPTLVILDADLPDGDGIEFCRWLNRQQQPLILMLSARTNEADIVAGLKAGADDYLSKPFGMQEFLARVEALIRRNRTPVAPAYLDYGALQIDLVQRRVRFQGEFIDLTPQEFSLLYVLAQAGGVPLSRSELLRRAWPDAIDNPRTIDTHVLSLRKKVELDPRQPSLIQTIRNVGYRFNMEILNSNIPQSPPKLPKERFSNQRSTLSTQRV
>NZ_AP018172.1|WP_096590972.1|5536933_5537716_-|ATP-binding-cassette-domain-containing-protein
MDNVTPKAILRLEQVNLFTKLKSQISANHQGYPILQDIDFELFPEERIAIVGSSGAGKTALFKLINRLIEPTRGKIFLENQEYRQIPIIQLRQVVTLVLQESKLLGMTVEQALTYPLVLRGLPKQTIQQRVSHWIEKLRIPSDWLGKTEVQLSIGQRQLIAIARALVIQPKILLLDEPTSALDIGTASHLMEVLTQMVPTHHTTILMVNHQLELAQSFCTRLLHLQQGRLLADCTASEIDWPKLRTSLMHADAQASEEWI
>NZ_AP018172.1|WP_096590974.1|5537771_5538305_-|hypothetical-protein
MTVSVFRLSPLIRITLLSLYLALTVPLPFLAQTTAAPIPPALLWLGICIGLVALYAVLTERVILDDQGIQVTYPVWVPRFFRKGWSLAWSEVKELKPRTTGQGGIVYYFLSQEGKAYLLPMRVVGFAQLVRQVQAKTGIDTTDVRPLAQPWMYVTLLGFTLLLLLIDAWTISTALNQ
>NZ_AP018172.1|WP_096590976.1|5538450_5538912_-|DUF4079-domain-containing-protein
MNLPSFLWLWKIAAWSMGLSLLAYLMLATTGFWMFQARTSQHPPSFPLLNRGLGGMRSLHYTIGISMVSLVLLLLAIGIIGTLGHFGSLGQSSHLIAGILVVVLVLLSAVSATQISTEKPWFRTLHVGINIILFIGFAWVSLTGWSVVQKYLP
>NZ_AP018172.1|WP_096590978.1|5539054_5539450_-|DUF1830-domain-containing-protein
MAQILDPLPPEQSGKILCCYMNATSKIQVARITNIPNWYFERVVFPGQRLVFEAPPEAQMEIHTGMMASAILSDTIPCTRLAINEPGTNELSNNSEVAIDSINTKPMVQPINTKTENTTKPLTIAGLASVD
>NZ_AP018172.1|WP_096590980.1|5540026_5541616_+|B12-binding-domain-containing-radical-SAM-protein
MAVKASTMENRILYVRLPCNPIFPIGVVYLSDHVHKQFPNIEQRIFDLGCVPPLDYVPALERCIDEFQPTLLVFSWRDIQIYAPVGGRGGNPLQNAFEFYYAKNPLVKLRGALGGLRIFIAYYVELWRNLGLIKRGLKRAQKYKKAARAIVGGGAVSVFYEQLGKSLPQGTIISVGEGETLLGKFLSGKEFRDERCYVVGETQPRQRLIHEQPTPLEKTACNYDYIESIWPEFNYYLQGQDFYIGVQTKRGCPHNCCYCVYTVVEGKQVRINPADEVVAEMRQLYDRGIRNFWFTDAQFIPARKFIDDAVELLQKIVDSGMTDIHWAAYIRADNLTPQLCDLMAKTGMNYFEIGITSGSQELVRKMRMGYNLRNVLQNCRDLKAAGFNDLVSVNYSFNVIDERPETIRQTIAYHRELERIFGADKVEPAIFFIGLQPHTHLEEYAFKQGILKPGYNPMSLMPWTAKKLLWNPEPLGSFFGEVCLQAWQQNPNDFGREVMKILEERLGCADLESALSAPMEKNEKQLVGV
>NZ_AP018172.1|WP_096590982.1|5542014_5543406_+|metal-dependent-phosphohydrolase
MLEGSILQQLESIHRRSSRPIRFGVYYKNTLVALCHALEDHILQDDGKPLVITAFQQGKWYLQEAERYADIAKYSDEIVIMAAPDAGFAEHPTSLLSNVDLVALDPADPVAQEWHLIILSPKYTAMVICQELSEADYGSAGLPASDVERKFYGLWTFEPELVRETAELAIAHIRPYNPQLADKLTAHKDSIQPSLVTPEDLSAVVSRVVDYLQTGQENLSLPTAPRQQVLDRNLVSNEIQAFLRMAQLMDLADINNPMAAAEVVALSETIGQLLNLPAWQIKRLRLAALLHRIDPLQKAESVLVPSSTRYHEETPSIPLSCPLVPGAQVLRTMPRLRAVAQIITHQTEWWDGTGEPAGLAGDEIPLESRILALVADFQWRVNQKKSSQISREEIFTQALDECKQQSTRFDPKLLDTLSLLVMGLQQGLDLPLIETKVTAGMWLIDSRWDSQSKTSEEIGTYPQ

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Crispr_ID: NZ_AP018172_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_17

5916777-5916866

Unclear

Consensus_repeat	Method
ACCTTTTTACTCGAAGTTTCCTGTTCT	CRISPRCasFinder

1 spacers

Cas9_archaeal

The CRISPR arrays of NZ_AP018172_17

>merge|NZ_AP018172|17|5916777-5916866|CRISPRCasFinder
ACCTTTTTACTCGAAGTTTCCTGTTCTAAAGTGGAACGATCGTGTTCTGAAGGCGATCGCTTCACCTTTTTACTCGAAGTTTCCTGTTCT

>NZ_AP018172|17|14|5916777-5916866|CRISPRCasFinder
ACCTTTTTACTCGAAGTTTCCTGTTCT	AAAGTGGAACGATCGTGTTCTGAAGGCGATCGCTTC
ACCTTTTTACTCGAAGTTTCCTGTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096591539.1\|5905983_5907106_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_AP018172.1\|WP_096591555.1\|5912261_5913569_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|182804
NZ_AP018172.1\|WP_096591569.1\|5919192_5919441_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096591577.1\|5922662_5923250_+\|cyclase	unknown	unknown	gnl\|CDD\|176875
NZ_AP018172.1\|WP_096591545.1\|5907485_5908013_+\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_AP018172.1\|WP_096591574.1\|5920636_5922670_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_AP018172.1\|WP_096591559.1\|5913962_5916602_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_AP018172.1\|WP_096591538.1\|5905574_5905841_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096591562.1\|5917249_5918125_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213022
NZ_AP018172.1\|WP_096595374.1\|5908133_5908595_+\|diacylglycerol-kinase-family-protein	unknown	unknown	gnl\|CDD\|260134
NZ_AP018172.1\|WP_096591572.1\|5919512_5919848_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096591547.1\|5908691_5909291_+\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|235552
NZ_AP018172.1\|WP_096591564.1\|5918187_5918577_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096591579.1\|5923819_5925739_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_AP018172.1\|WP_096591550.1\|5909294_5910062_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|316044
NZ_AP018172.1\|WP_096591582.1\|5925705_5926335_-\|cytochrome-bc-complex-cytochrome-b-subunit	unknown	unknown	gnl\|CDD\|224209
NZ_AP018172.1\|WP_096591542.1\|5907287_5907443_+\|DUF3285-domain-containing-protein	unknown	unknown	gnl\|CDD\|314535
NZ_AP018172.1\|WP_096591552.1\|5910307_5911618_-\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_AP018172.1\|WP_096591567.1\|5918593_5919112_-\|HNH-endonuclease	Cas9_archaeal	cas9_archaeal	gnl\|CDD\|224321
NZ_AP018172.1\|WP_096591584.1\|5926424_5927120_-\|lipase	unknown	unknown	gnl\|CDD\|224001

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096591539.1\|5905983_5907106_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_AP018172.1\|WP_096591555.1\|5912261_5913569_+\|M24-family-metallopeptidase	gnl\|CDD\|182804	PRK10879, PRK10879, proline aminopeptidase P II; Provisional.	3.05549e-154
NZ_AP018172.1\|WP_096591577.1\|5922662_5923250_+\|cyclase	gnl\|CDD\|176875	cd08866, SRPBCC_11, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	5.16281e-61
NZ_AP018172.1\|WP_096591545.1\|5907485_5908013_+\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	5.8669e-54
NZ_AP018172.1\|WP_096591574.1\|5920636_5922670_+\|GAF-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.03871e-35
NZ_AP018172.1\|WP_096591559.1\|5913962_5916602_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	3.21854e-16
NZ_AP018172.1\|WP_096591562.1\|5917249_5918125_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	9.01965e-74
NZ_AP018172.1\|WP_096595374.1\|5908133_5908595_+\|diacylglycerol-kinase-family-protein	gnl\|CDD\|260134	cd14265, UDPK_IM_like, Integral membrane undecaprenol kinase and similar enzymes. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of undecaprenol to undecaprenyl phosphate. C55-isoprenyl (undecaprenyl) pyroposphate acts as a scaffold for the assembly of peptidoglycan components; undecaprenol kinase (UDPK) is involved in recycling undecaprenyl units for re-use in the peptidoglycan biosynthesis. UDPK does not participate in the de-novo biosynthesis of undecaprenyl phosphate. Gram-positive bacteria have a large pool of free undecaprenol, in contrast to gram-negative bacteria. UDPK may also play a role in a stress-induced pathway that affects the function of ribosomes. In Streptococcus mutans, UDPK has been shown to be required for biofilm formation, such as in the case of smooth surface dental caries. Members of the UDPK family have low activity as diacylglycerol kinases (DAGK), and many of them are annotated as DAGKs.	3.32089e-40
NZ_AP018172.1\|WP_096591547.1\|5908691_5909291_+\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	6.26569e-125
NZ_AP018172.1\|WP_096591579.1\|5923819_5925739_+\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	3.52492e-75
NZ_AP018172.1\|WP_096591550.1\|5909294_5910062_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	3.59972e-71
NZ_AP018172.1\|WP_096591582.1\|5925705_5926335_-\|cytochrome-bc-complex-cytochrome-b-subunit	gnl\|CDD\|224209	COG1290, QcrB, Cytochrome b subunit of the bc complex [Energy production and conversion].	1.69704e-41
NZ_AP018172.1\|WP_096591567.1\|5918593_5919112_-\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	1.30412e-28
NZ_AP018172.1\|WP_096591552.1\|5910307_5911618_-\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	2.27694e-07
NZ_AP018172.1\|WP_096591542.1\|5907287_5907443_+\|DUF3285-domain-containing-protein	gnl\|CDD\|314535	pfam11688, DUF3285, Protein of unknown function (DUF3285). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	1.18859e-22
NZ_AP018172.1\|WP_096591584.1\|5926424_5927120_-\|lipase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	5.53875e-28

>NZ_AP018172.1|WP_096591559.1|5913962_5916602_+|tetratricopeptide-repeat-protein
MARVSYGDYVIARVRTLLERFLAYVNDELEDGELYKIALNWETPQQVIVRTQLRVLAELSGLSKEQVRDSLNALKDFVEILEDLREHKRGSENWHFRLTLWHDKSDKHGNLQKFDAEWQSRREKLPGVQRAEGRKAKLSPTRYENIPLSGVVEFVGRETELQNLHQLLQSNQQVAIAAIAGMGGVGKTELALQYANLHRVTYQGGICWLSALQDVGVQLVQFARNQLQLNIPDDLDLVGRVQFCLTKWHEGEVLLVIDNVTNYREEVRSYLESVPFRFKQLITTREKLQPQIVRLDLDVLTPLAAMQLLKSIVGRERLRREALVARKLCKWLGYLPLGLELVGRYLLVDEELTLAEMLQDLENERLKHEALEQVPQEMAVKLGVAAAFELSWRRLRENAQRLGCLLSLFALAPIPWELVEGITINNAAQDWKKARRDLLQLHLLQPKGEGIYQLHPLLREFFQDKLTGLEQAEDFKRSVCGVMVAVAKNIPDTPTLQQIKTFSPAIPHLAEVASNLIQYINDEDLIWPLIANARFYNGRGLYVQAEPWYKKCLEITKKRFGQEHPNVASSLNSLALLYHSQGRYSEAEPLYLQALELAQNLLGKNHSDVASSLHNLAALYHSQSRYSEAEPLYLKALALKRHLLGEEHLDVASSLNSLAEFYRSQGRYSDAEPLYIQTLVLRRKLLKEEHPDIALSLNNLALLYYSQKKYSEAEPLYLHALKIWRHLLGKEHPNVASSLNNLATLYYSQGRYIEAEPLYLQALALRQHLLGEKHPDVALSLNNLAGLYRSQGRYIEAEPLYLHALALRQHLLGEKHPDVALSLNNLAELYRSQGRYSEAEPLYLHALDIFEQRLGMNHPYTVTVRKNLAYLRDRLNSQQ
>NZ_AP018172.1|WP_096591555.1|5912261_5913569_+|M24-family-metallopeptidase
MQAEYQKRRQQLMSKLGNGTAIFRSAPMAVMHNDVEYTYRQDSDFFYLTGFNEPQAVAVLAPNHPEHQFVLFVQPKDREKEVWTGYLCGVDAAKELYGADEAYPIHELDEKLPQYLEKADRIYYHLGRDRTFNDTVLKHYQSLLRTYPKRGTGPIAIEDTGAILSSMRLVKSEAELELMRQAAAIAIEAHNHALKFTAPGRYEYEVQAEIEHIFRLRGAMGPAYPSIVASGVNACVLHYIENQRQMQDGELLLIDAGCAYGYYNSDITRTFPVGGKFTPEQKILYEIVLEAQKKAIAQVQPGNPFNLVHDTAVRVLTEGLVEVGILKGEVDKLIEEEKYKPYYMHRTSHWLGLDVHDVGVYQHGENPQILQPGQILTVEPGLYIVPDTKLAEDQPQTDPRWVGIGIRIEDDVLVTSTGHEVLTAGVPKEVDEVER
>NZ_AP018172.1|WP_096591552.1|5910307_5911618_-|VCBS-repeat-containing-protein
MSDKSLDTNSLSSAPLAITASPFDGASNSGYINRSSASELTSEVPNTVSAQSLFGGANNNPNPYLSSAAIVPDFNGDGKTDKIWVDAQTGDTQVWLMDGTTVAAKGSLGQIDLASTVYKIGDFNGDNKTDFLLRNQVTGQNTIVLMDGTNVARLVPLDTLDSSWTPLIGDFDGDRKTDIFWRNTQTGENALWLVDATNPGQAVKSGTKLDALDPSWTPTMVDFDGNGITDIFWRSATGENSAWFINGTQVNQSSLQSQDPSWNFTVGDFNGDMRSDFLWRNTTTGENKVWLTNSLIPNNVFFTESSLTTLDANWTSSIADFNGDGKTDIFWHNQSTGENTSWLMDGGTIVTQTFLAPSSTTAQATFGDFNNDGRTDIYWRDYGTGADEIWTTNPDGTTVTRTPVADTDKLPAVQVGEDGNPLVGPDGLPLKKWMTF
>NZ_AP018172.1|WP_096591550.1|5909294_5910062_+|MBL-fold-metallo-hydrolase
MKRRQLMGYAGAGLATAFLTTLGSEFQADAQSSGLSVQWLGHTCFLLTGGGVKILVNPFRPVGCTAGYRPPKVAADLVMISSQLLDEGAVDGLPGKPKLIYEPGVYEFQGIKFQGIAIDHDRKGGKQFGVNTAWSWKQGGINILHLGGAAAPISAEQKILMGRPDVAFVPVGGSAKAYNAQEAKQAVEILNPKLIIPTHYRTKAADASKCEISPVDDFLNLMQGITVRRSDSDSISISPSNLPEKSVIQTLSYKF
>NZ_AP018172.1|WP_096591547.1|5908691_5909291_+|aminodeoxychorismate/anthranilate-synthase-component-II
MIIVIDNYDSFTYNLVQYLGELAAEFPVAADIKVFRNDKISVDEIRALNPELVVISPGPGRPEDAGISLDLIEQLGSNLPILGVCLGHQSIGQVFGGKIVSAPELMHGKTSQVTHTGVGVFRGLENPLTATRYHSLVIDRETCPDVLEITAWVEDGTIMGVRHRNYPHIQGVQFHPESVLTSSGKQLLRNFLEELQSRE
>NZ_AP018172.1|WP_096595374.1|5908133_5908595_+|diacylglycerol-kinase-family-protein
MSQQVSPPPTSNRLPTLVTKEREFSWQVATNLLISFKYAWAGISYSFKTQRNFRIHVGVCAVAIASSIVLHLSAVEIAVIGITSGLVLALELLNTALESLVDLTVKQTYHELAKIAKDCAAGAVLVSALVAVLVASMLILPPLATLIMSAISV
>NZ_AP018172.1|WP_096591545.1|5907485_5908013_+|rRNA-maturation-RNase-YbeY
MQVELDVQDCFYESSPEKTEDLGTNDNRIAEETWERWFKCWLEILHSDLPTAPGYEIGLRLTDDAEIQSLNAQYRQQDKPTDVLAFAALEVDCPQNEEMFASMPLYLGDIVVSVDTAKRQAQQQQHSLQTELAWLVAHGLLHLLGWDHPDEESLERMLKQQVILLREIGIALDIE
>NZ_AP018172.1|WP_096591542.1|5907287_5907443_+|DUF3285-domain-containing-protein
MSNSPSTETQPSYVKLAMRNMVRKGGTSIKHFVLTTIGLLAVFVGLAYLTR
>NZ_AP018172.1|WP_096591539.1|5905983_5907106_+|peptide-chain-release-factor-2
MEVLELKREIETLSYRLGKTQDYLDIPALTAKIQDLEQISAQPEFWNDQTQAQQTLQELNDLKAHLQQYHQWQANLEDTKAVVELLELETDEGLLEEAESTITKLNHELDQWELQQLLSGPYDDKGAVLTINAGAGGTDAQDWAFMLMRMYTRWAEAHGYKVTLAEESEGDEAGIKSATLEITGRYAYGYLRSETGTHRLVRISPFNANGKRQTSFAGVEVMPQIDSSVQLEIPEKDLEITTSRSGGKGGQNVNKVETAVRIVHIPTGLAVRCTEERSQLQNKEKALTRLKAKLLVIAQEQRAQEIAQIRGDMVEASWGNQIRNYVFHPYQMVKDLRTNVETTAITDVMNGDLDAFIQAYLRQENQLVESTPA
>NZ_AP018172.1|WP_096591538.1|5905574_5905841_-|hypothetical-protein
MHPKEDSSFFYVRVPARVLGCLRSGEITIILFPGHGLVLIEPIPTDFIPENLRMPNSEFDVLFKHPGREMVRVLRHNELCPEIDASKE
>NZ_AP018172.1|WP_096591562.1|5917249_5918125_+|polysaccharide-deacetylase-family-protein
MSFWHPDVTHNQYQRQKIISGVAIAFSVTACSINPIGINSPLKTQQISSKLHAVAVPQPKIISQDNPQSQPSTKVENLSFRLPEKFQGQTVYHVQPNNNEKVIALSIDDGPWPKTTLQMLDILKQNDVKATFFWVGQALQANPEIAKQVVAEGHAIGNHTWHHWYRRMDEATAKNEIERTNELIYKTTGVKTTLFRPPGGVLNNGLAAYAKSQKDAVIMWSQTSADTDPHAKYQVFIKNVLRDAKPGSIVLMHDGGGDRQRTVQALPEIISRLKQQGYRFVTVPELLEMQK
>NZ_AP018172.1|WP_096591564.1|5918187_5918577_-|hypothetical-protein
MLKLTYTERSFYLECLNLSLEEWVSQRVILALRVGQSICVEPSTASFLLPVDLPGVEKLKAEVIRNDSEIMALSTCDTEYLEVTLRGSWLSNGSEEAVGVFVTKMSDRTEFFLHKIWQEAQACARAMSE
>NZ_AP018172.1|WP_096591567.1|5918593_5919112_-|HNH-endonuclease
MTIAMQVLEQSVVVFSQNYLPLCRVNIKRAIVLLVTNKAEPLSLSTDAGWKIHSPSLILDVPKHIRLKIASGERTWKVPPVNRREVLRRDHHSCQYCGSKKSLTLDHVIPRSQGGPHTWNNVVIACERCNSYKGNRTPSEAGMQLRTKPKAPVHPAISFAEQFWNNVQANLE
>NZ_AP018172.1|WP_096591569.1|5919192_5919441_-|hypothetical-protein
MKFSVKSIYSISTSLGATNCRASRELASLGVEYFFMGNGGQKHGQITEGNYDFRYLSIDGLNAKPQLDARSGRYRRSHTVPT
>NZ_AP018172.1|WP_096591572.1|5919512_5919848_+|hypothetical-protein
MHTIARTSTTDMEVTSIRLERELKEKLKDIAGNQGYQALIRDILWNYVQQKSGEWKPRFSRTDIRASIAATAQQEERCVLTGQVIQPQQPMLLGLTRNGDMVPLSVESLAG
>NZ_AP018172.1|WP_096591574.1|5920636_5922670_+|GAF-domain-containing-protein
MKKRLSSPPQCPDDVDRLQSYPVKLMQHPEEPAHKLLQQINQIVANRQATVLMLQDLAKLLGETFGVDCCLVTVMSEPSTEATTASWCTEQYLGLPQSDEIFSMEQLLMELHVVPCAAEPLNIEDISTIQKSLEIGCQSLPLPIKAVLAIPTRFRGKNNGVISLIKFQPHNWTQSEQQLLKSVESSCAIAVAQVAQSQLIVLQQQHLQKSDQYQSLIRQLTILSRSNLELKQMLQLAISSTAESLQADRGLFIMVKYTDPLFRTRSKKQIPNAKATVIGQWTRDAQSYPSSTSDILKDQSFVVSECGLCQRIFTESGKPVVINDYTEQKDIVTAAPLFAVDQFRAVLLMPLESQGKVLGFLVLQQASARSWQAAELNLVEMVCAQVSNSIIQSQTLRQVQNLVDERTAKLQSSLELQAKLHERTRQYVEQLRELNELKDEFLSNMSDRLRYPLTNMLMSIRNLRLPGITPERQNRYFDILEQECTKEINLINDLLTLQKLESQQATPQFETIDLNTRIQDLAASFDRKLAEKGLSITLDLPEESLKLQTEVESFDRILQELLTNACKYSEHETIVDLHATHQVNQLVDQVIIKVTNIGRGISSEEATYIFDKFRRGKGRWTPGTGLGLALAKSLVQHLNGTIAVESMQISDSDLSKICFTLTLPQFSDESKLYSDSD
>NZ_AP018172.1|WP_096591577.1|5922662_5923250_+|cyclase
MTEQPNTSADIDFNAASDKTNPELNLAVDTDSSPSVEIQIEKIAERQRQITAKIQIPHPVEQIWKVLTDYEGLVDFIPNLAKSRLLDHPNGGIRLEQVGSQRLLNFNFCARVVLDLQEYFPKEIKFCMVEGDFKGFSGSWCLEPYYFGEIIGTNLCYTIQVWPKLTMPVGIIENRLSKDLRLNLLAVYQRVTQLV
>NZ_AP018172.1|WP_096591579.1|5923819_5925739_+|sodium:proton-antiporter
MEASFEITLQMVAAVVAGISAQVLAAYLRVPSIVLLLLLGILLGSDGIGLLHPHLLGTGLEVIVALATAIILFEGGLNLDVRELGRVSVSLQLLVTLGTLITLLGGSMAAHWLGEFPWNIAFLYASIIVVTGPTVINPLLKQINVDRQVATLLEGEGVLIDPVGAILAFVVLDTILNGDADPLNAIIGLLMRLGIGGAIGAAGGYLMSLIFKRATFLSFELKNLVVLAILWGLFTLAQTIRSESGVMTTVIAGAVFANSSVPEERLLRHFKGQLTILSVSVLFILLAADLSIASVFALGWGSLFTVLVLMFVIRPINILLCTWNSDLNWRQKLFLSWVAPRGIVAASVASLFAISLTQRGINGGDAIKALVFLTIIMTVVCQGLTAGQIAKWLQITSKEATGAVIVGCNPLSLLIARFFQERGENVVIIDTDPDCFAQAEAQNLRVIASSALDTAVLEEAGLASIGTFLAMTSNGEVNFVLAQRAAEEFNPPRVLAVFPRDPQANSSATSKVNQAFVSDLAIKTWNEYLNDGRVKLGTTTLNELEFASQQDRIQEKIRTGVLIPLLLEREQRLQVMPVNQEWEVGDRIIYLLHDPRPNLLKRLSGANQSTRLSLEKLPEVEEVPLAKLGQLSTSEASGS
>NZ_AP018172.1|WP_096591582.1|5925705_5926335_-|cytochrome-bc-complex-cytochrome-b-subunit
MQSTQFDRILRRLATILSVVILTLCLIDLTTGVLLSFYYEPTAGGAYRSLKMINTAVPYGWLFHKAHDFSGNAVIAIALIQIVVMFLGRQFRKSWLTAWISGILFTLSAIALDWTAMLLDWTQEGYWRFSIELGTIEAIPLIGGQLRDILIGGGAINTITVQHLYALNSYIISPVALLLAVVHLSALLWQEREMYSNFTQLPEASLVES
>NZ_AP018172.1|WP_096591584.1|5926424_5927120_-|lipase
MSLPTVILPGYLESASAYRQLEKSLQQLGFPTVTVPLRRRDWIALLGGRPVTPILWQLDRTVKQILQQYNSSQINLIGHSAGGWISRIYLGDRPYSGRGQVISSLWQAHPCVATLITLGTPHVSQERWTRWNLDFVSNNYPGAFYKNVRYVCVAGKTIFGERRPGRWLAYSSYQLTCGQGNTWGDGITPIVAAHLDGAENIVIEGVRHSPRSPGIWYGSPQTLQTWIKYLA

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Crispr_ID: NZ_AP018172_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_18

6744087-6744174

Orphan

Consensus_repeat	Method
GCGATCTCAGAAACTGTAACTTCAGTGG	CRISPRCasFinder

1 spacers

PD-DExK

The CRISPR arrays of NZ_AP018172_18

>merge|NZ_AP018172|18|6744087-6744174|CRISPRCasFinder
GCGATCTCAGAAACTGTAACTTCAGTGGTTGTGATTTAAGGGGTTACGATTTTCAAAATCGCGATCTCAGAAACTGTAACTTCAGTGG

>NZ_AP018172|18|15|6744087-6744174|CRISPRCasFinder
GCGATCTCAGAAACTGTAACTTCAGTGG	TTGTGATTTAAGGGGTTACGATTTTCAAAATC
GCGATCTCAGAAACTGTAACTTCAGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096595419.1\|6734919_6735615_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096593077.1\|6754083_6756591_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_AP018172.1\|WP_096593082.1\|6757276_6758797_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|226702
NZ_AP018172.1\|WP_096593068.1\|6750564_6751383_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096593052.1\|6740882_6743744_+\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319781
NZ_AP018172.1\|WP_096593044.1\|6736455_6737883_-\|phosphoglucomutase/phosphomannomutase-family-protein	unknown	unknown	gnl\|CDD\|100093
NZ_AP018172.1\|WP_096593031.1\|6731600_6733175_+\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235050
NZ_AP018172.1\|WP_096593036.1\|6734073_6734793_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|226983
NZ_AP018172.1\|WP_096593039.1\|6735824_6736052_+\|CopG-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226420
NZ_AP018172.1\|WP_096593057.1\|6744860_6745994_+\|DNA-replication/repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NZ_AP018172.1\|WP_096593071.1\|6751434_6752607_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376267
NZ_AP018172.1\|WP_096593059.1\|6746423_6746837_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096593079.1\|6756821_6757274_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_AP018172.1\|WP_096593046.1\|6737988_6738846_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378929
NZ_AP018172.1\|WP_096593041.1\|6736095_6736374_-\|DUF1049-domain-containing-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096593034.1\|6733345_6733939_-\|hypothetical-protein	PD-DExK	mkCas0061_PD-DExK_CAS-I:CAS-III	unknown
NZ_AP018172.1\|WP_096593074.1\|6752971_6753628_-\|DUF1361-domain-containing-protein	unknown	unknown	gnl\|CDD\|226780
NZ_AP018172.1\|WP_096593062.1\|6746885_6747323_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_AP018172.1\|WP_096593066.1\|6748086_6750489_+\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|223647
NZ_AP018172.1\|WP_096593049.1\|6738921_6740592_-\|transglutaminase	unknown	unknown	gnl\|CDD\|224224

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096593077.1\|6754083_6756591_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.21339e-57
NZ_AP018172.1\|WP_096593082.1\|6757276_6758797_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	1.05443e-53
NZ_AP018172.1\|WP_096593071.1\|6751434_6752607_-\|hypothetical-protein	gnl\|CDD\|376267	pfam18848, baeRF_family6, Bacterial archaeo-eukaryotic release factor family 6. Bacterial family of the archaeo-eukaryotic release factor superfamily. Likely to play roles in biological conflicts or regulation under stress conditions at the ribosome.	9.21274e-59
NZ_AP018172.1\|WP_096593052.1\|6740882_6743744_+\|cation-translocating-P-type-ATPase	gnl\|CDD\|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_AP018172.1\|WP_096593044.1\|6736455_6737883_-\|phosphoglucomutase/phosphomannomutase-family-protein	gnl\|CDD\|100093	cd05800, PGM_like2, This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.	0
NZ_AP018172.1\|WP_096593031.1\|6731600_6733175_+\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235050	PRK02546, PRK02546, NAD(P)H-quinone oxidoreductase subunit 4; Provisional.	0
NZ_AP018172.1\|WP_096593036.1\|6734073_6734793_+\|Uma2-family-endonuclease	gnl\|CDD\|226983	COG4636, Uma2, Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only].	8.08272e-15
NZ_AP018172.1\|WP_096593039.1\|6735824_6736052_+\|CopG-family-transcriptional-regulator	gnl\|CDD\|226420	COG3905, COG3905, Predicted transcriptional regulator [Transcription].	7.47464e-11
NZ_AP018172.1\|WP_096593057.1\|6744860_6745994_+\|DNA-replication/repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	3.57476e-151
NZ_AP018172.1\|WP_096593079.1\|6756821_6757274_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.79931e-57
NZ_AP018172.1\|WP_096593046.1\|6737988_6738846_+\|hypothetical-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	1.55106e-12
NZ_AP018172.1\|WP_096593074.1\|6752971_6753628_-\|DUF1361-domain-containing-protein	gnl\|CDD\|226780	COG4330, COG4330, Predicted membrane protein [Function unknown].	7.10486e-61
NZ_AP018172.1\|WP_096593062.1\|6746885_6747323_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	4.13219e-47
NZ_AP018172.1\|WP_096593066.1\|6748086_6750489_+\|phosphoenolpyruvate-synthase	gnl\|CDD\|223647	COG0574, PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism].	4.79778e-123
NZ_AP018172.1\|WP_096593049.1\|6738921_6740592_-\|transglutaminase	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	1.50086e-24

>NZ_AP018172.1|WP_096593052.1|6740882_6743744_+|cation-translocating-P-type-ATPase
MSANSLPEGAAVWHNLEVDKALDLLDSNADSGLTPQEVEQRLQKYGPNELEEHGGRSAWEILLDQFKNIMLLMLIAVAIISGVLDLLAWRGGNLKPGEVPFKDTIAIMAIVILNGILGYVQESRAEKALAALKKLSSPLVRVIRDRKLVDVAAKDLVPGDVMLLEAGVHIAADGRLIEQSNLQVRESALTGEAEAVNKQATLQLPEDTGLGDRLNVVFQGTEVVQGRGKVLVTNTGMQTELGKIAAMLQAVESEPTPLQQRMTQLGNVLVTGSLILVAIVVIGGIIQARGFSNLQELLEVSLSMAVAVVPEGLPAVITVTLALGTQRMVRRNALIRKLPAVETLGSVTTICSDKTGTLTQNKMVVQSVFTNNSTFRVTGEGYAPTGDFQLNEQKIAVDERPEIAALLVACAICNDSVLQKEKGEWAILGDPTEGALLTLAGKAGIEKDQWNSKLPRVAEFPFSSERKRMSVISQVEEIATGESSLRGIDPAIAGFLQSENYLMFTKGSPELILARCSQIYLGTHAVPLTEEQRQKILAENDQMASKGLRVLGFAYKPLREIPPEGSDETSEQELVWLGLVGMLDAPRPEVRAAVQECRQAGIRPVMITGDHQLTARAIATDLGIAEEGARVLTGQELQRMSDEELEQNVDLVSIYARVSPEHKLRIVKALQRRGRFVAMTGDGVNDAPALKQADIGIAMGITGTDVSKEASDMVLLDDNFATIVAATKEGRVVYTNIRRFIKYILGSNIGEVLTIAAAPLLGLGGVPLTPLQILWMNLVTDGLPALALAVEPPEPDVMKRPPFSPRESIFARGLGSYMVRIGIIFAIITIILMEWAYFHSKAVTGPGLDPERWKTMVFTSLCIAQMGHAIAIRSNNQLTIEMNPFSNLFVLGAVVVTTLLQLMLVYVPPLRDFFGTHWLPPGELAVCIGFSALMFVWVELEKIFFRLMGKKTV
>NZ_AP018172.1|WP_096593049.1|6738921_6740592_-|transglutaminase
MSFALPTMTVSQMFGQRTIRPLSAAALGGIAFIKDTLIAIDTVKGHLLEIDPISDNSKILNPHQVQEFTEVTGLAVWEDALWVTRGKSVYRCKLNALGLEHFVTLPYPADGVAVWESTVYVSCQKLGYILIYEADSRKEITRFYAPGVGVENLAVSNDTLWVSDRTEQTVYSLDRATGEIQFSVLTPFDSPTGIAVHKDAETGKESLYVAYASEEPYIRDNPNADPNHELTYRDRTFIHPLHYHYEPEKRYALSNGYLIEMSYAEEIAPLEEVYLTDLEWRIALPSETERQKVKHVEPIGLPFTEEVIDGQRVAVFKFDTLTPGERHIFGWKAILEVRGIKYRITPKDVEDIPELSPEFETRYLVDDDDLAMDTTIVRRSARDAVGSETNLLRKMYNIRNYVYDELSYGIKPYIDTPDIVLERGVGSCGEYVGVLLALCRLNGIPCRTVGRYKCPPHGELQGVPLQPDFNHVWLEFYIPNIGWLPMESNPDDVGNAGPYPTRFFMGLCWYHIEIGKGIPFETISSQGVRLTKEDIPIGDLAINHIRFTILKELPPF
>NZ_AP018172.1|WP_096593046.1|6737988_6738846_+|hypothetical-protein
MSIPDRPFASYHLWSLVAPATGQERWHCQMRRGFVKARQHEPQVKALLAKATAPQRIGILAQKGVYEFHHHRHLLKQSDGVEKVAQLLQLSHASEEVQQRVLQILQKYHNAPLLLNKNILQLTPGDEGFPKPILIDQDDYCFRLYAAMDCVFIDSDRTLHILDFKTGKAAFDQRQALVYLLAARYLYPGHEAVASFYNLELGKKSELIRIDRSELASLEFELAHIAQKHQRDLQKYHQETEDFSQIFPPNPGSHCRFCPFRSICDFADVKQPQAFAMPILKVNGA
>NZ_AP018172.1|WP_096593044.1|6736455_6737883_-|phosphoglucomutase/phosphomannomutase-family-protein
MSASSKSSKIKFGTDGWRGIIADDFTFPNVRKVTRAIASYLETAYSKDRPVLVAYDTRFLADQFAQTAAQVLADLGWTVKVTDRDCPTPVIAYNARHLNSAGALMFTASHNPAPYCGIKYIPDYAGPATPEITDTIVANIESASDEPPSGSPSGSISIFDPKPDYLQFIYTLIDVEKIKSAQLKVKYDALYSTSRGYLDEVLQQSGVQLESFHTWRDVLFGGGMPEPKGEQLVELVEAVRTDKADLGLATDGDSDRFGIVDEQGNVLTPNTVLLLLARHLIKNKGKSGAIVRTVATTHLLDNFAAKYGLPIYETAVGFKYIGEKMRETTVLIGGEESGGLSVIGHIPEKDGVLADMLVAEAIAYEGKPLSQLVKEAIAEADGPLYNNRLDLHLTEAHKTAVIDSFTKNPPTEVAGIKVKEVGRKDGIKLYLEEGSWILLRPSGTEPLVRVYLETNSPEKLTTIAQEMESAIAKLE
>NZ_AP018172.1|WP_096593041.1|6736095_6736374_-|DUF1049-domain-containing-protein
MKTIANLLISVIVAVWVMAIALLSVQNATPVRLKFLSLQSIQIPVGLLLAFCVCLGLVGIAVLQPLWGLADSRRGNSRLDEDAEFFVDDEDF
>NZ_AP018172.1|WP_096593039.1|6735824_6736052_+|CopG-family-transcriptional-regulator
MTFQIDSDKKIALDAIASGINRDRSYVLNEAIDAYLEMHHWQIEEIQRGITEAETADFASDEEVKATFAKLTNTN
>NZ_AP018172.1|WP_096595419.1|6734919_6735615_+|hypothetical-protein
MNVKLGFGSIPKPQYVFVNRENDYCWYMLAEDKKHIPIYEKALTGVITAIEVNKKIETSFGESEKTDLYILADKPYIVRSGSDSYFSKSLLLSLDALTLEQLRHPLTIAVSPGDKKVVFCNIYDPVSYRSIGVSWDGYKELNWQALEQKVSVKINGHQNIKPEQIQTSSNTSQSELHAVLIAQTDTYLAQLNWSPEQGREYLQQKYGRRSRHHLSDTELLDFIDFLKLQLT
>NZ_AP018172.1|WP_096593036.1|6734073_6734793_+|Uma2-family-endonuclease
MLLMLNYNPLHCSPSSEELPNSDDTPVDNQLQHLIPALLESTLALSWSDRWDWFFGVNMGIYYDANQPAIVPDGFLSLGVKRFVDEYLRLSYVLWEENESPILALEVISQIHRGEYSTKKEFYAKNLGILYYVIYNPLRRKKSSLEVYRLVDGEYLLLSGSPVWLPEIGLGIGRERGIYQGIVREWLYWYDEEGQRILAPEERIQEAEERFTFEEQQRVAVEKRARMLEERLKDLDIEP
>NZ_AP018172.1|WP_096593034.1|6733345_6733939_-|hypothetical-protein
MPYSQFSIENIEANFDITITESVGIFADISSVEYSSFLEQTLKKYVPLALAIGTEKSRSELILTPILVELKERFQNKISLFSGREFNVSPEKGLTGFCDFLISKSPEQIIIKAPVVALVEAKNDNIQSGLGQCIAEMIAAQLFNQQKGNEIEAVYGSVTTGTNWKFLRLTGKIIEIDLNEYFLSDVGKIIGILSSFI
>NZ_AP018172.1|WP_096593031.1|6731600_6733175_+|NADH-quinone-oxidoreductase-subunit-M
MNTANFPWLTTIILLPIVASLLIPIIPDKDGKTVRWYALVVGLIDFALIVYAFYTGYDFSNPDLQLVESYPWVPQLDLKWSVGADGLSMPLIILTGFITTLAALAAWPVTLKPRLFYFLLLAMYGGQIAVFAVQDMLLFFLVWELELIPVYLLLAIWGGKKRQYAATKFILYTAGGSLFILLGALTMAFYGDTVTFDMRSLGLKDYALNFQLLLYGGFLIAYAVKLPIIPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALIRMNAQMLPDAHAYFAPVLVILGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVTIGIASFTDLGLSGAVLQMVSHGLIGASLFFLVGATYDRTHTLMLDEMGGVGKKMQKIFAMFTACSMASLALPGMSGFVAELMVFVGFATSDAYSSTFKVIVVFLMAVGVILTPIYLLSMLREIFYGQENEELVSHQALIDAEPREVFIIACLLVPIIGIGFYPKLLTQMYDSTTVQLTARLRDSVPTLAQQKEAPKVSLVAPEIGN
>NZ_AP018172.1|WP_096593057.1|6744860_6745994_+|DNA-replication/repair-protein-RecF
MFLKSIHLRQFRNYTDQKVEFSAAKTILVGNNAQGKSNLLEAVELLATLRSHRMARDRDLVQEGEAIAQVNASLERQTGISDLSLTLRRNGRRTVALNGESVRRQMDFLGVLNAVEFSSLDLDLVRGGPEGRRSWLDTLLIQLEPVYAHILHQYNQVLRQRNAFLKHTQDSALSTQHAEQLAVWDAQLATTGTRVIRRRERAIQRLAPIATKWHSSISGSTETLQIEYAPSVPLGDNYPQEVQQAFLDKIQQRAVAELRQGTTLVGPHRDEVELIINQTPARQYGSQGQQRTLVLALKLAELQLIEEVVGEPPLLLLDDVLAELDLYRQNQLLDAIQDRFQTLITTTHLGSFDSQWLNSSQILLVKAGEISLPNDIY
>NZ_AP018172.1|WP_096593059.1|6746423_6746837_+|hypothetical-protein
MSQQNHILNKDEIVALGTSLRGIEQKLLKQSQQSGIKRIWFQGEEPYFDVFFELKNDEIIWFQFTLRGKALSWDSRKAKLQTGTTNELHYNDVSFYAASKTIENDIETNWEFVNLVKSILETRATETIFAKALKLFN
>NZ_AP018172.1|WP_096593062.1|6746885_6747323_-|MgtC/SapB-family-protein
MSNDLLSIVFRLFIALLSGAIIGLERERRHKPAGLRTHMLVSLGSAIFTVIPLYTVELKPSADALSRVIQGIAAGVGFLGAGEILRESSQESQRSEVHGLTSAAAVWVSAALGIAAGCGLWQLGLIGALLTFLVLYVFKRFEKRN
>NZ_AP018172.1|WP_096593066.1|6748086_6750489_+|phosphoenolpyruvate-synthase
MDKLYWLDQIKLQDRAKVGDKAFYLSRIMQRGYPVVPGFVIGAEVLQEFLETLNSSESLVADLPHSSLHLDVANWRQLQQVAGRLRQEIITANVPESWVSKILTAARKWESEHLILRPTVMVANTTQPVGNISGLLESVFCPCNPEAIALGLKRAWSQLFRARSLLYWQRSSTNLQQVNLAVLVQPIRDAIASGLLNANTSGWEITATCGLEVAIANGEVLPDVYYIQPETGQLIEQQLGNKILAYRLDNIAAKDDLRSLPPSVLSLENTSLVAYLLEENQQKDYALSTDYLHKIIGLGNQLLTELGNNFDIKWTISQETPTPKLYLTQVSTPQSAIPHLQIIKGLGAARGRVTGTAFVITNSSSKPEQLPQGAILVARTIQPDWLPLLQRVTGIITEQGGLTSHAAILARELGIPAVVSATDVTALIQSGERLHVDGDRGEVSRARENTAAERTPPRWSSGENLELNYSPSSMPSLPADSNSRETFTPRSAFSAPQPIIATQLLLNLSQSSLIAQVQSLPVDGVGLLRSELMMLTILEGQHPNSWLVDGRQAELLELWTDQIMRFARGFAPRPVLYRSLDWRSHELPSFPHQYQSSSQAVLGERGIFSYLLNPTIFELELAALAAVQKAGYSNINLLLPFVRSVEEFSLCRQKVEQAGLTQIPQFQLWIMAEVPSVLFLLPEYVKAGVAGISIGTNDLTQLLLGVDREQEQLAKKFNELHPAVMGAIAQLIEMSKDAGIPCAICGQAPAIYPEIIDRLVQWGITAISVEPEAVERTYQAIARAEQRLILEAARRQLKGG
>NZ_AP018172.1|WP_096593068.1|6750564_6751383_-|hypothetical-protein
MSSIRYFFRHSLVSLAILSSAVLAQVATAETITGKSGDVQAQISYEKPQEYQYKNVRLKITRSGQTILDQKLPQDSEYDRPIGDLLEAPDNKLPVLDLDGNKEPEVIADFFTGGAHCCTYSLIYRYNSKSNQYQKIRHEWGNGGYRLRDLDKDGLPEFDSRDDRFAYAFSSYAASGYPLQIWQYRQGKMVDVTRRYPKLISSHATELWQTYTEARRQGDDGKGFLSAYLADKYMLGQSQDGWQRVQQAYKKSDRSQFFADLRKFLRETGYIK
>NZ_AP018172.1|WP_096593071.1|6751434_6752607_-|hypothetical-protein
MQIISREEIRPLLEQPKGNCISIYMPTHPAGPEVRQDPIRFKNLIKEAEARLVDAGLEPQEATALLQKAIDLDTQEFWEQLGELGLAIFISKDFFRYYTLPLNFQELVVVTDRFHIKPLLPILNGNGRFYILALSQQDVRFFEGTHYTINEVEVENLPKSLEEALNQDETAKEGQFRIASSKGGTANTFVQPGEFHGQGSPDRDQHQEEIRQFFYIIDRALHEKLRDDTAPLVLAGVEYLLPLYRQANTYQHLMAEGIAGNPEILSAQELHDRAWPIVEAEFQKSQQDFMERFQQLFGGDTGKATNDLKQIIPAAYYQRVDSLLVAVGQQQWGLFDPSSENVYIHEEKETGDEDLLDLVATHTLLNGGTVYAVPPEQIPFSTPVAAIFRY
>NZ_AP018172.1|WP_096593074.1|6752971_6753628_-|DUF1361-domain-containing-protein
MKAELIELITKLFQVLQINMRWMTWNLFLAFIPLALSVWLFRRNRGRSWVWWLGFLGFYAFLPNAPYLLTDVIHLIDDIRTIQSVWVITLVLIPLYILVIFAGFEAYVISLINLGYYLHRIGKSQWILWVELITHALSAVGIYWGRFLRFNSWDFITQPDAVLTKGLEELLGKQPLVIIAITFIILIGLYAIMKRVTLGWVRQPKTEIPINSQQTKNG
>NZ_AP018172.1|WP_096593077.1|6754083_6756591_-|response-regulator
MLRILLIDDNPNDRHLAIYALQQEFSHLQIQEIGQAQDFEQALTAGEFDLVITDYQLRWSDGLTVLKAIKSRYPDCPVVMFTNSGTQEIAVEALKSGLDDYVIKSNRQSLRLPKAVRRAWENTEAQRKVAGLETRLQTLLNNLNVGVYRLQADGTLLEGNPAFFRLVGLDRINTIPENQTLESYFQREEYAELLSQLKHNSPGRDRQVPENEVREIPLRRADGTTVWVRLSKTFTTVNGITIIDGLMEDITERKQSEQKLRDSLAREQILRTKAEALEHRSSFLAEASRLLVSSLDYRTTLALVARLAVPTLADLCLVDVVGENNFIAYSEPIVAASNSELEALALELRSSNPPRANANYGSPKVLRTQQPELVIEIPDPVTGSNTKDPTHINFIQKLHITSYAIVPLTARERKLGTITFAVVQSERRYGRAELEIFQELAQRVALAIDNVRLYLDAQKANRVKDEFLAIVSHELRTPLNAMLGWTNLLRTRQMDAATQAKALETMERNAKLQRKLINDILDISRITQKSLHLNLQPIYLPLVVKSAIEDLQIVAQTKSIVVESNLDSHVKPVLGDTERLQQVMWNLLSNALKFTPQGGRVSVELKQINSCVQLTVSDTGQGISADFLPYLFDAFRQADATTTRTHAGLGLGLAIVQHLVEMHNGMVFATSDGEGKGATFTVQLPIYQPQVTQPNRVEQTRQQDFPSLPGLRILVVDDDEDTRQMLAFILEQCEVQVTTAASATEALNIFSQSKPDILLCDVGMPHEDGYSLISKIRSQEDDRQRIPAVALTAFARDEDRQQAIAAGFNQHLAKPVNLYELVAVVVSLAQQTAIA
>NZ_AP018172.1|WP_096593079.1|6756821_6757274_-|response-regulator
MNPHRDDILLVEDNPKDVLLIQRALRKANISNSLQIVNDGDAAVLYLSGEEPYSDRTLYPLPVLILLDLKLPRRSGSEVLRWLRQQPLLKRIPVVVLTSSKEYADINLVYDMGVNAYIVKPVAFNDLVEIVKTLNLHWIVFNEKPQVETA
>NZ_AP018172.1|WP_096593082.1|6757276_6758797_-|hybrid-sensor-histidine-kinase/response-regulator
MPQPTQALKVLVIDDNPGDRALVIRQLRRELTQLQAQEIRDATELSNAIAIDNFDLVITDYQLLWSNGIEVLRAIKQRYPSCPVIMFTNTGSEEIAVEAMKSGLDDYVLKQPNRYTRLATTVRVVLERLEIQRRATLLEVRLQGLLNQLKLGVFRATATGDLLECNRAFLELLSVNSLAQAQAMQPFNLQENYTQLLNLPSPQQQEIEVELRRADGRLMWTLLTTTLRKIEGESVIDGLIEDITVRKQAEIEKSQLNEILEQRVRERTRELEETNRQLAVANQDLEEFAYTISHDLREPLRAISGFSSILLRNQDAQSQANQDYLRRIIDSTQQADRLIEDLLAYSRLSRTDIPVQPINLSILISEILRQLQPELQQRQAQVQIAQPLAEVMGNRTILIQVITNLLTNAIKFVSPGVTPQIRVWSEQRENRIRLWVEDNGIGIAQQYQQQIFQVFNRLHSNEVYPGTGIGLAIVRKGVERLGGNAGVESQPQQGSRFWIELLKAVD

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Crispr_ID: NZ_AP018172_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_19

7416249-7417846

TypeIII

Consensus_repeat	Method
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	PILER-CR
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CRISPRCasFinder
GTTTCCATTCAATTANTTTCTCTAGCGAGTAGAGAC	CRT

21 spacers

cas10,cmr3gr5,cmr4gr7,cmr5gr11,cas2,cas1,csx18,WYL

The CRISPR arrays of NZ_AP018172_19

>merge|NZ_AP018172|19|7416249-7417846|PILER-CR,CRISPRCasFinder,CRT
GTTTCCAACCGATTAATTTCTCTAGCGAGTAGAGACCAGATTACAGTTAGTTGATGGAACCTATCACTTCCAATTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGACTCATGAATAATCTCGGTGAATTGATAACCGCACAAGTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGACTGTTGAAACCAGTTTTCAAAGGATTCCATAATAATGAAGTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGACGCCATTCCCTTTGGATTTTTGATCCAGCAAATTATGGGGAGTTTCCATTCAATTAGTTTCTCTAGCGGGTAGAGACTTGTTGGAATAACTGGTCACTAACTGAAATAACTAGTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGACTTAATTACAGAGTATGCCGTTGTAACTTTTAGCGATAAGTTTCCATTCAATTAGTTTTTCTAGCGAGTAGAGACTCAATGGACAATCTATGAGTTGCGATCGCCGTACATGGTAACGTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGACTTCGATATCATCCCACTTGAGGATAAAAGCAGTATTTACTAGGTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGACACGACTAGGAGCGCATTATGACATTATCCTGGCTAACTGGTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGACCCGACCTGTGGCTCGGGCCAGATCTCGCTGAAGCTCGGCAAGTTGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACTTGTTATTCGCGCGTTTAATCTCGTTCCAAATGTGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACGTTACAGAGTAGACCCGATCGCCCTACAAAACGCGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACCTGGGGAATAACTTGCGCCAAGGTTCGGCTACTTTTGGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACATCGCTTCCACACTGAGCACGATCGCACTGTGGGCAGGAGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACTTCTCTGTTTATTTTCCATGCCAAAATGCATATTCCTATTGAAGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACTTTAGTCAATACGGCGCACAAAGGTTTTTCGACATTGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACCTTTCTAGGTGTCAATCAAACTTAGCAGAAGTTGAAAAAGGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACCCTCAAAGAGAAGGGAGTAAGTCTATCAAAGATTGCAGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACAAGTTAGTCAAAGTTAAGACTAACGTTTCAATTCCGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACAGCATAGAGCTAGTTGTCATGTCTTATCAGATGATGTGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGACCCACATGGCAATCCGAACTTGCTTGATGGTTTCGCTGCGGCTCTTGTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC

>NZ_AP018172|19|10|7416249-7417846|PILER-CR
GTTTCCAACCGATTAATTTCTCTAGCGAGTAGAGAC	CAGATTACAGTTAGTTGATGGAACCTATCACTTCCA
ATTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TCATGAATAATCTCGGTGAATTGATAACCGCACAA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TGTTGAAACCAGTTTTCAAAGGATTCCATAATAATGAA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	GCCATTCCCTTTGGATTTTTGATCCAGCAAATTATGGGGA
GTTTCCATTCAATTAGTTTCTCTAGCGGGTAGAGAC	TTGTTGGAATAACTGGTCACTAACTGAAATAACTA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TTAATTACAGAGTATGCCGTTGTAACTTTTAGCGATAA
GTTTCCATTCAATTAGTTTTTCTAGCGAGTAGAGAC	TCAATGGACAATCTATGAGTTGCGATCGCCGTACATGGTAAC
GTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGAC	TTCGATATCATCCCACTTGAGGATAAAAGCAGTATTTACTAG
GTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGAC	ACGACTAGGAGCGCATTATGACATTATCCTGGCTAACTG
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	CCGACCTGTGGCTCGGGCCAGATCTCGCTGAAGCTCGGCAAGTT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTGTTATTCGCGCGTTTAATCTCGTTCCAAATGT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	GTTACAGAGTAGACCCGATCGCCCTACAAAACGC
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CTGGGGAATAACTTGCGCCAAGGTTCGGCTACTTTTG
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	ATCGCTTCCACACTGAGCACGATCGCACTGTGGGCAGGA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTCTCTGTTTATTTTCCATGCCAAAATGCATATTCCTATTGAA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTTAGTCAATACGGCGCACAAAGGTTTTTCGACATT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CTTTCTAGGTGTCAATCAAACTTAGCAGAAGTTGAAAAAG
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CCTCAAAGAGAAGGGAGTAAGTCTATCAAAGATTGCA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	AAGTTAGTCAAAGTTAAGACTAACGTTTCAATTCC
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	AGCATAGAGCTAGTTGTCATGTCTTATCAGATGATGT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CCACATGGCAATCCGAACTTGCTTGATGGTTTCGCTGCGGCTCTT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC

>NZ_AP018172|19|16|7416249-7417846|CRISPRCasFinder
GTTTCCAACCGATTAATTTCTCTAGCGAGTAGAGAC	CAGATTACAGTTAGTTGATGGAACCTATCACTTCCA
ATTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TCATGAATAATCTCGGTGAATTGATAACCGCACAA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TGTTGAAACCAGTTTTCAAAGGATTCCATAATAATGAA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	GCCATTCCCTTTGGATTTTTGATCCAGCAAATTATGGGGA
GTTTCCATTCAATTAGTTTCTCTAGCGGGTAGAGAC	TTGTTGGAATAACTGGTCACTAACTGAAATAACTA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TTAATTACAGAGTATGCCGTTGTAACTTTTAGCGATAA
GTTTCCATTCAATTAGTTTTTCTAGCGAGTAGAGAC	TCAATGGACAATCTATGAGTTGCGATCGCCGTACATGGTAAC
GTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGAC	TTCGATATCATCCCACTTGAGGATAAAAGCAGTATTTACTAG
GTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGAC	ACGACTAGGAGCGCATTATGACATTATCCTGGCTAACTG
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	CCGACCTGTGGCTCGGGCCAGATCTCGCTGAAGCTCGGCAAGTT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTGTTATTCGCGCGTTTAATCTCGTTCCAAATGT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	GTTACAGAGTAGACCCGATCGCCCTACAAAACGC
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CTGGGGAATAACTTGCGCCAAGGTTCGGCTACTTTTG
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	ATCGCTTCCACACTGAGCACGATCGCACTGTGGGCAGGA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTCTCTGTTTATTTTCCATGCCAAAATGCATATTCCTATTGAA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTTAGTCAATACGGCGCACAAAGGTTTTTCGACATT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CTTTCTAGGTGTCAATCAAACTTAGCAGAAGTTGAAAAAG
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CCTCAAAGAGAAGGGAGTAAGTCTATCAAAGATTGCA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	AAGTTAGTCAAAGTTAAGACTAACGTTTCAATTCC
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	AGCATAGAGCTAGTTGTCATGTCTTATCAGATGATGT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CCACATGGCAATCCGAACTTGCTTGATGGTTTCGCTGCGGCTCTT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC

>NZ_AP018172|19|10|7416249-7417846|CRT
GTTTCCAACCGATTAATTTCTCTAGCGAGTAGAGAC	CAGATTACAGTTAGTTGATGGAACCTATCACTTCCA
ATTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TCATGAATAATCTCGGTGAATTGATAACCGCACAA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TGTTGAAACCAGTTTTCAAAGGATTCCATAATAATGAA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	GCCATTCCCTTTGGATTTTTGATCCAGCAAATTATGGGGA
GTTTCCATTCAATTAGTTTCTCTAGCGGGTAGAGAC	TTGTTGGAATAACTGGTCACTAACTGAAATAACTA
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	TTAATTACAGAGTATGCCGTTGTAACTTTTAGCGATAA
GTTTCCATTCAATTAGTTTTTCTAGCGAGTAGAGAC	TCAATGGACAATCTATGAGTTGCGATCGCCGTACATGGTAAC
GTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGAC	TTCGATATCATCCCACTTGAGGATAAAAGCAGTATTTACTAG
GTTTCCATTCAATAAGTTTCTCTAGCGAGTAGAGAC	ACGACTAGGAGCGCATTATGACATTATCCTGGCTAACTG
GTTTCCATTCAATTAGTTTCTCTAGCGAGTAGAGAC	CCGACCTGTGGCTCGGGCCAGATCTCGCTGAAGCTCGGCAAGTT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTGTTATTCGCGCGTTTAATCTCGTTCCAAATGT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	GTTACAGAGTAGACCCGATCGCCCTACAAAACGC
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CTGGGGAATAACTTGCGCCAAGGTTCGGCTACTTTTG
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	ATCGCTTCCACACTGAGCACGATCGCACTGTGGGCAGGA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTCTCTGTTTATTTTCCATGCCAAAATGCATATTCCTATTGAA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	TTTAGTCAATACGGCGCACAAAGGTTTTTCGACATT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CTTTCTAGGTGTCAATCAAACTTAGCAGAAGTTGAAAAAG
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CCTCAAAGAGAAGGGAGTAAGTCTATCAAAGATTGCA
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	AAGTTAGTCAAAGTTAAGACTAACGTTTCAATTCC
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	AGCATAGAGCTAGTTGTCATGTCTTATCAGATGATGT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC	CCACATGGCAATCCGAACTTGCTTGATGGTTTCGCTGCGGCTCTT
GTTTCCATTCAATTAATTTCTCTAGCGAGTAGAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096594161.1\|7412973_7415946_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|378863
NZ_AP018172.1\|WP_096594159.1\|7410883_7411765_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NZ_AP018172.1\|WP_096594165.1\|7419817_7421014_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NZ_AP018172.1\|WP_096594168.1\|7425738_7426521_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594154.1\|7395042_7401363_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350681
NZ_AP018172.1\|WP_096594167.1\|7422662_7425173_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|316042
NZ_AP018172.1\|WP_096594155.1\|7401359_7402286_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594163.1\|7418315_7419308_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NZ_AP018172.1\|WP_096594166.1\|7421134_7422214_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096595446.1\|7402285_7402600_-\|chromosome-segregation-ATPase	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594158.1\|7410374_7410872_-\|hypothetical-protein	cmr5gr11	mkCas0205_cmr5gr11_CAS-III-B	unknown
NZ_AP018172.1\|WP_096594156.1\|7407036_7408590_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594153.1\|7394606_7395023_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_AP018172.1\|WP_096594162.1\|7418031_7418310_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_AP018172.1\|WP_096594160.1\|7411820_7412960_-\|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NZ_AP018172.1\|WP_096594164.1\|7419313_7419598_-\|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	unknown
NZ_AP018172.1\|WP_096595447.1\|7425259_7425526_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369087
NZ_AP018172.1\|WP_096595448.1\|7426690_7427881_-\|DUF3596-domain-containing-protein	unknown	unknown	gnl\|CDD\|271177
NZ_AP018172.1\|WP_096594157.1\|7408665_7410375_-\|RAMP-superfamily-protein	unknown	unknown	gnl\|CDD\|213662
NZ_AP018172.1\|WP_096594169.1\|7428188_7429226_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368554

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096594161.1\|7412973_7415946_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|378863	pfam12469, DUF3692, CRISPR-associated protein. This domain family is found in bacteria and archaea, and is typically between 101 and 138 amino acids in length. The proteins in this family are frequently annotated as CRISPR-associated proteins however there is little accompanying literature to confirm this.	1.25679e-42
NZ_AP018172.1\|WP_096594159.1\|7410883_7411765_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	1.49869e-27
NZ_AP018172.1\|WP_096594165.1\|7419817_7421014_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.80809e-13
NZ_AP018172.1\|WP_096594154.1\|7395042_7401363_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|350681	cd17923, DEXHc_Hrq1-like, DEAH-box helicase domain of Hrq1 and similar proteins. Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.13784e-50
NZ_AP018172.1\|WP_096594167.1\|7422662_7425173_-\|AAA-family-ATPase	gnl\|CDD\|316042	pfam13481, AAA_25, AAA domain. This AAA domain is found in a wide variety of presumed DNA repair proteins.	6.25062e-22
NZ_AP018172.1\|WP_096594163.1\|7418315_7419308_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	4.08511e-107
NZ_AP018172.1\|WP_096594153.1\|7394606_7395023_+\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	1.13704e-07
NZ_AP018172.1\|WP_096594162.1\|7418031_7418310_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.86126e-29
NZ_AP018172.1\|WP_096594160.1\|7411820_7412960_-\|CRISPR-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.18891e-67
NZ_AP018172.1\|WP_096595447.1\|7425259_7425526_-\|hypothetical-protein	gnl\|CDD\|369087	pfam06806, DUF1233, Putative excisionase (DUF1233). This family consists of several putative phage excisionase proteins of around 80 residues in length.	0.00372755
NZ_AP018172.1\|WP_096595448.1\|7426690_7427881_-\|DUF3596-domain-containing-protein	gnl\|CDD\|271177	cd00796, INT_Rci_Hp1_C, Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain. Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.98228e-17
NZ_AP018172.1\|WP_096594157.1\|7408665_7410375_-\|RAMP-superfamily-protein	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	4.16306e-10
NZ_AP018172.1\|WP_096594169.1\|7428188_7429226_-\|hypothetical-protein	gnl\|CDD\|368554	pfam05672, MAP7, MAP7 (E-MAP-115) family. The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.	4.80422e-08

>NZ_AP018172.1|WP_096594161.1|7412973_7415946_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MSEAYWQAKIWGLLHDPVLKALHNNTGRGCNSFWQELEVMQNWVSNGWNPEESHRKILEHIKLADYISSASDRGAIGSVSASIDYAHGNSEQGLEISHLLSGAKRNFKIKQHSQMLTANRKNYLDSQEQKLREAIPVEVRTDIKGVFWWLWRCLPAATCQEFADESLILMPAETRLPDSSIWSHASITAALAGALAGYDLTAPEIQHWPANKTLSHPYLATFTFTPVQELIKASRKMRDFWAGSWLLHYLSAKICWELAQKYGPDCFLYPSLYQQPLIDHWLLQEFPKFDQWIKKPDANQLLTAGFPNVLVLVLPKDKVKAAMQMAKQKLLQEWTRIGNLVFEELHNKRYWMPDLGEDSKTWQGWLESQWQFYWTALPIGKEGKKLKNAAIPKERETEFLEWLDIQNQAYVINQKYNLFQNEEIDFLREAYQQRWEKQKRKFSVNVGSWWASIFDTNRYALAAVKNARNWELPTAFGLRSTISGIGPVVHPGGDWIKEGETKKYWEHHAGLFDGREQLNATETVKRVLEKVLDKLLDIKNEDVVAASYPDLTAGVAGYLKVNEKDINHESRFEDTCQAIIAKNPWAKGVIQEMKNKWGIPWIDKDNLPQRFHPRLLNAGWLVEDAETPELRVLQEKIKTANEQDQEVIRREISDLKKNYRQEIQKIIDSFYPGNNPADWYVLAAGDGDDMSEWLQGKKLEKYGDYIPSQLSVSLASFQKFLAVKKRMGPSTHNALSRALLDFSNQLVPYLTQQRYAGRLIYAGGDDVLAYTNLWEWDNWLWDIRQCFRGDEDPQGEFDSGDDYWTAKAMLSQQVATRPLFTMGRNATISFGMIIAHHSVPLAIALENLWDAEKKAKEHKTPDGTKKDAVQVRVLYSNGNILQATTKFPTFDGWRKLICANVGDTAIFEQAASLWSQHPAPNLEAILPWTKAFCDRRDQFPGDETAKTQFQRNLANFLEGLVLTTKEKDLDNEIQNWLKLAAFIKRNRDIK
>NZ_AP018172.1|WP_096594160.1|7411820_7412960_-|CRISPR-associated-protein-Cmr3
MYWYKLTPLDILMLRDAKPFSPQERAWAGSTFPPNGYTIVGALRELLGEKKDFNIIGPFLCFENKGNSLYFPRPLGFVKSTPLVPLVWETKSPLHNVIFRDETQPFPLVKPVNSPTEDEEEDSIKCEGSEAKFRQYLPYSVVKTYLETGKIEKDDWQVTSGSYEDQPWTIETRSHNSIEPGTRQVKDAEGYFVENAIRLNTGWSLAISVDTNIDTPTTLRLGGEGHRAIFQRCDELGEQWANLQQISQANFKSQSKSIAYLITPGVFERNHKTTINNSRCRAYPWEWKLAHTVNKNQTPGDLVSVATEKPIPISCRFRDKDEIHKSISAPQVFAAPPGSLYYLNQPRSLFQDNKQTKLNNWRKLGYSELLWINYELEIV
>NZ_AP018172.1|WP_096594159.1|7410883_7411765_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MPDFRVGYIYSLAPIHCGGEGDLGNILEIAREVHTNFPYVPGSSLRGTLREEVNLQDETAVDILFGKELDKQGQMGVHQVWFGDARLLWVPMRTMSMNGGRDVFSWVSCHSLIRAHAIITQQNSVIFPDQAVGTSAGTYLVADAQIEVSQMSNEQKQATTLAGNWPNSLKNAVQQTWEKNRIVLPDADFQVLMEHSLWTQVRNKIQDETTGANQAGSAEVFWTDVCIPRDTIFYFSWGYSLLKNKPVKPEEHDILMSVLQGLFQVGGQANVGRGWVQGWTNNATSPSQVKVGV
>NZ_AP018172.1|WP_096594158.1|7410374_7410872_-|hypothetical-protein
MPDQLKRPQPPQTAKANSMTPPTKLVNVDSGFSSTQVLPEQMSLVAHEHIQTYLKNQRKSNLDKNDLTAVLRLSQHLRVFGLLSAVGYVNQSNAQGGEVRERTVPVWESLLGQMMNQANPPQREQMMEQVVEMTKKQPQQYMATWRRSLMLANHWNFWARAYQED
>NZ_AP018172.1|WP_096594157.1|7408665_7410375_-|RAMP-superfamily-protein
MYTGSRLIELLELQHQRRSQSGLFKKDTFTIQWRAKVGSFPHPDIETIVSAGEPCGAWRPTQGRPEDKRNVNENWERLRILPLNGYIPGASIRGLVRAWAKQRPDILPRMYELLGYQNNDTITAGKIEFLDAWPDEPTKLTLDIVNPQQEFQVYHQGQGTPLSLYTLGDGKDYIPVTVAIRGIPGRATDAEVSEVWGWVQQALSLYGVGNRTASGYGTLKFSDSLKPTPDPDCTVKQFDFSLYSQGSAGPNMQTMELRPSHWRGWLRSWILRFLLGVMSQQDAQKTVGELLGTLEPQTRKGCVRLQMLKSLTWGDSSSGQPRFYAWKGKLQISAPKDILNTIILPIIRFAVMVGGVGRGWRRPLHIFHMNTGKAAARGTLLTLTHKLRNRTTQEWETKPYGLPLDAATWAKAYSDWLAAVQSQWPDRVTADNHNINAEVFSPNTCAIYAVPGSDTEAIQRQEPCWKQADDAEATRGDGMYLIYQPTAPRNYKRNPEIGGNAGAGNASCSWASIKRVNIPNKEQETDCQEIVCLFMGGQTPNSNHVRSRFLRDLGRMSGAVHLFGVQASN
>NZ_AP018172.1|WP_096594156.1|7407036_7408590_-|hypothetical-protein
MTTISTEANHVDTLIITVGTRQVGWRCQDGVIRSFGADGNIGYPCHVQELYHELGIERNFHQENDINSPWSARDLGKRYYEYCIEWLGGDFSQVELLLDQKIIEIAIKKGLKHIILWGTDQPETVSWTFRRLDTLWLAQLMAGKIKSIFPDVRVDVHAPEINAIDSYAIRQELELLVLQEALNYFCPASNEEFVLWIENKGCAPAVASSVEICAAALVRQCQVFNASPDEPEEFFPRMPNGSRTAAHSQTFKLIPMGEYFWSLERLRVISAWERGDFSEAQLWLKVHQSRHKILYKLAGILVRYTNWETDQFIKSIGSWLNDDVTEVVTKEQIQSWQEQLNSIKVDKITKAWEFTLLIELAIYRKNYTTAFIQFVHTLERLLYIQFQEKNWLSQGFVSIPPEKAYLGTSYQPGMAGLIEGWRKSQNLDKNNKWYRLLDSLREKRNQVIHSGKSVTLGQLCSFWNADSLFPEKIVEDPTVVNDLMIELLKQVSTAPELDKLLVRSLYKWALKVLQESS
>NZ_AP018172.1|WP_096595446.1|7402285_7402600_-|chromosome-segregation-ATPase
MSPLPPIKQKLPAPVSSRWYLLNVRSHKRGLFLKHLQFAIAKNNLQEVILEIKIPQDSVYGDIVLVNLSNFKIANSHLQKIDYFQSIERQPLPLEQVSRMIGNQ
>NZ_AP018172.1|WP_096594155.1|7401359_7402286_-|hypothetical-protein
MCFDEIILLLSNHRHPINQAIPTTLTKHQLITLIRSSLSPNESQEQLQSQVEEALSELQAQGEIYAGVRNRYCIAPPTSLALDKDNLTGLRFRGDRTYLPLAHQVLKTEQSHDNLSIRPNIRGFYQIKNRLNQAGIRLLTVADSIEHLPYPSQPSKAVLRSRWSENPFLANNGQGQGSIQQYLPSCDTPQKNRWIPLNYHQLQDKSLLQLPTGEYLWFQDQAFYELEPDTAMLAMFYQDQETGYPLKIHWDKPQGRLNLQGTSLPSAYAQLLWRLSEPDSERYRTRLIQPLHHPLVETIFQRLGSLLV
>NZ_AP018172.1|WP_096594154.1|7395042_7401363_-|DEAD/DEAH-box-helicase
MTKNSNYLDPIAAVEQPRQDFIRYLLTAYPLRDPHLRYGLKQQLEVPGTVWQHPYLEGSQPYRPANSVSALINQDLLHPEMAGLFTPNQRPLYEHQETAVKAVIQQQENIVVATGTGSGKTECFLIPMLDMLLREEENLSIAGVRALILYPMNALVNDQVKRLRKLLCRQETIKIRFGFYTSRTETEEHKAEESLAQELQAYDSQELQDLFTETEQASLNLSTRERLIDQAIAKIQKIQAISRREIWEKPPHILVTNYSMLEHMLIRPMERNKVFASSASTFKMLVVDEAHTYNGSTGSEVSMLIERLKVAVKQEKPGQIRCIATSASLGDVSVTQQILEFTTKFFGESFNQVIRGERVTAIERLGEAYELPPEFTNEEILEYLSIIELPKIDDNLSFWIDRLSGFIPTEQLKVAESKSQGDVHKLLWYALKQHPLVHRFIELLRRKPQPWEQITQLPEVWGVNLPFNPDGTINDTETKLALAHLLQLGALARENSDDLPLLPVRIHLLFRSLEGLYACINPECPGGVCDPDYLNKPLRYGRLYLNDKSTCDDCNSPVLELGSCYQCGQAYAFTQLNGASKLQPLPRSNQGLRENEKIYTLTSGLLDSITEEEETGEQEQEQELSSPTTLIIRQRDGWIGLPTLEQVPNKSSHPNEFSLVWHRPKDAKDLNGCYLPKCAACGTRPIRSQAINRFVAYTDEPLEAMIDSLFELLPESPENQGSASKRKLLTFSDGRQDAAFFASDYQRNHTETLYRQVIWQAFQEFKSDDNIVSINQLINRVKQYFLETSIPHPDRDSRKNYLSYYPEDEESLENFRDCQDSAEARAKELLLREFALPFNRRSTLEAYALFACHLELRDERLIEWVAREFEISNAEAEIFLIVLADIIRRTGIVSVEGASRYFPETGGVEGVRPEMVDVQGKSKNYLFLKKSGDEIKKFQDSPSFLPKLKEKTGEVSQVQNRLGWYYLQLFGKNLPTNDKFVALFRQLQDLRLLVPAKNGHQLNWAKLNIIQTQHDWYQCDCCQQIIHVPGLSDIQKSQTKLNIFGCPAFKCSGKLQPYNADKIEQVTNDHYQRYIIKNRLPLPLRSQEHTAQLGVGELEKRENRFRRGQINLLSCSTTLEMGVDIGELQAVVLRNFPPHVSNYQQRAGRAGRRTDGVAITLMYGQRRPHDRFYFEQPEQLIAGNNQIPKLDADNFQIQQRHIRAELLAEFLKAKDKGAEKVTIAEFFSLPLHNFSSTLNFSPPPTSIFCELQEWLHSDDAHSVAQVWINKLKISYSATDILNDFFAALLIFQQQELADWNDLVPLLKDIQKSIATEADRTKRKGLEKRRDSIEAELEKIGKRRLHDELVQASVLPIYGFPIDVVRLLTGDSNEFKSSQGKHRLERDRRLALGEYAPSQDIVVDDRVYQSVGILRPSDLEKKYYWVCKNCNHFEVSITENIIEECSVCGWEATPASAAKMKLYKVPKAFTTDWSVTPKVTPYTKPQRQPTSQVFLAKPGENQEQLESQFYKLTVSKGGTLFLANQGSLGHGKGFSKEGFAICQSCGRDLSELVQKQREANNTKGGSKKQAASFKASSTAHKHPNTARDCSGSGYPLIHLGHEFRSDLLKIEFQAAKNLIPLFGEVVHYGDGGTVSSVTEQTNQSTDGMGFWRSLTYALIAAAAEVIDVPRAELDGLFRPLQNQLAEIIIYDNVPGGAGYSRRIADHFFEVLEKALEIVASCSCDTSCYDCLRTYSNQAFHAEINRKIVADFIKYLVMKPDPELQDFAPNANRAKLSQMAVRLPGLCRMAGKVSMIYLPSLIDGFNLNNGSLLSWIKLIKDVVSSMERSEIPLELILNQLPQPNTAASDSVRRNLQLLQKHLQQWVDKGALKLYQTSVNDVPILCLSTQQQHRIALQLHTKSEDGMLEWFETRSSEGVETVFQRLEKWRSQARLVEAKELEDVNTTVIFPDRSWSNLTISQLRQRLGIDRVLSGSGGVNIVYSDRYLNEKGAKIIADLLKADGLNANSSISIRVLEEFQGDSVSQRKANLEAALAEIKSMGVSIKVSVQPWQQQQRSHFPHARMMEVQTVNGQRYKIIFDKGIDFLELKTTGVYSVTEPTYIVINKQV
>NZ_AP018172.1|WP_096594153.1|7394606_7395023_+|HNH-endonuclease
MSSITLYLQIKQRRQHPNLPVYWWRRQPLEQWELTRQRIYQRDRGICQSPTDTPPKIQGLCMGEVKLRVAHIDHIRPLSSGGSNHASNLRTLCPVCHALRLDRKHDGMRNGLVKKGLIPVNWKQFVWDEIVGDRQPDS
>NZ_AP018172.1|WP_096594162.1|7418031_7418310_-|CRISPR-associated-endonuclease-Cas2
MLLYVVAYDIPCDKRRKKVSDLLEGYGIRVQYSVFECVLTTSQYNELHQRLRKKVKLSEDKIRFYPLSGHTLNQIQVWGGPPVTEIPGSTII
>NZ_AP018172.1|WP_096594163.1|7418315_7419308_-|CRISPR-associated-endonuclease-Cas1
MRTLYVSQQNCYVSLQKETLIVKQGEIVQGQVQLPLLEQILIFGKSQVSTQAIRACLWREIPIVYLSRMGYCYGRILPIGRGYRQLCRYQQQLTQVERLITARAIVQAKLKNSRVLLRRQRRRQESELLEKVLQNLDRLVSQAATADNWDRLMGFEGAGAAQYFSVFGECLTNPEFVFMGRSRRPPGNAVNAILSFGYQVLWNHLLALIELQGLDPYYACLHEGSERHAALASDLIEEFRAPIVDSLVLWLVNKNVMDAQNDFEYRDGGCYLNDLGRKKYLKAFLQRMEEEVQIDDGEKQPRWHLLTTQVKAYKQFVYNPAQIYQPYLIR
>NZ_AP018172.1|WP_096594164.1|7419313_7419598_-|hypothetical-protein
MYISPRASRVRNILVSVSTGSITLVILLIAPLGLAAVLINTLLVTFATYIVSSVADRVIAWLEPAADADLISDSGGQKQNLARQQRQSTFQRWR
>NZ_AP018172.1|WP_096594165.1|7419817_7421014_+|WYL-domain-containing-protein
MPKKPTSHAYGDAKAFERLMLLIATLLKHPGVGSPDFIESSDKEQHNSLKQVQLCLQKLAASYGVELPKGYPSIPTLRKDIETLRRYGILEDRMYRWGYYLGTGAMSQEELKVAFNALASQAKYQGDGILRRIYQTLSKRLRGLDLELKGEFSYPVRQHLNRAIVYTDPEEMAALGQNRDTLFHQLAVVEKAISQGQTIEISRGSDPYGNSRIGPQRIIPLQLIYQDIAWYLLHEHCENGHLVIGRLNRFKNYCQVLHESGRGLEAQRNSLAKAHQLLENGWGLSLGEPPEQQLELQGKLELVTAKVRFFPPVATFIQEGERRHPKQKIVLGPKNATTGKPSYVDYVVSLPPRSLDEFSFWVCRYMDKARVISPTQLVKKHYQAAQALLSHYNSVEIE
>NZ_AP018172.1|WP_096594166.1|7421134_7422214_-|hypothetical-protein
MYLMVCSPEISRANGRKSNGPKTLKGKQVARLNASQHGLLATKVPIIGEDAFKFQQFMEELIGEFQPESPTEITLLEQVAIARMRLYRLWMTESALASHALTPAPPLEPPTVAKYPYYEKDDYELKNKTLFHPDNRALERELTLALVEILKIYRDLDKDVRKKYFNSIWSEWLGDAEKGITKFLYQHPYKSITVNPLCYSNAVEYANACQEFVTEQKKKQTLYGEVSQLQVLIRIAQQDLTDNQYPKTKNQLRCSIVKFQIDKVEKKCRERLNELEKIEKEIIQVEREHQKAIADYQELTRRSQLIPPQIELLSRYERHIVRMMNDALDRLQSMRQQRQQANSMGSFRNCEVQATIPAL
>NZ_AP018172.1|WP_096594167.1|7422662_7425173_-|AAA-family-ATPase
MLMETTSIHNNFLSDRNTAIEWLSQHGYPALPVAPKQDPFKYPKRDKNGNIEYEEDGKTPKPKFTGKNPSYLDENNEPHLVFHSNYQNSLPTQSERDKWFANTLNGVGTLGGWNKTVWIDFDVKNFDSQQECDRLVSDWLNRYSVLKETFIELTHSGGWRIGIRVRKMPEFTNFTLSPGGKHVGECLGKGRFTVLSPTIGPSGNQYQSINRAKLVEVEDLESIGLYSTKKQASTKLQSSLIQLDLAPHAIPLEEFFSEKPKDILNGTNPNGDRSEALTTLAKEAFGWQNWCFDNGISTSGDAENIVELAGKKLRIDSDRIQRILKTIDSSSCQPSAQYLGGEESCWLKIRRLDKGTFEAKCPAAIKLEIENNLTTDVINTSKSSNNNKNVQHKISRDEAIKRARKVINAGLDELEENLQLEEIREQAGLSSYFWERKVITNLRRESLPTRLTLEIEAFLCETNPQKQIIERSRILSRYQISAKEFEQQCQAIQYAEKQTQKKPRLLALSEVFASEGKAFQWQVEGIIPKGVSGMLSGLPGASKTLLTVDLAYCIVTGTPFLGEKVKPGKVLIINSDQPLNVTANYLSSRGFDDNDANIKVIGELHEMAAWTINDLVLLESYLQEFQPDLVIIDSIRATIINPLGIEEKSELIGYWLKKVERLVIKYSATLLWVHHDNKQKDYTGVSRASGSTAIAGSVSFHYRIEKVSKDQSDPHRILSMAKTRGYEPVTLKLMYDSTTGIFQNMGHEGESPETARERQSLRQRIMEFLERNPGQKYELEEIQAAVGGENVGVELSKMSRRGMIANEKSLKNPRKKVYFVESTQPPPSQVTPTSGS
>NZ_AP018172.1|WP_096595447.1|7425259_7425526_-|hypothetical-protein
MNNFVTKKQLSNQIGLSSETFKRYRLQGIWQESIHWQKINSRTTLYNLPLILDWIANRDNPQAHQRAIEAYLHSLPSNQPLKRGRKVS
>NZ_AP018172.1|WP_096594168.1|7425738_7426521_-|hypothetical-protein
MSENLLFVPNPYVLVPSPYLIAPSAFQINNPLVILVAVFEEITSEEQNQDLIQTVTGRQLLQYHKAVVGEFYRQNIDAKFPHWKLKRNERAIIKPEVEIWKAVLTMLEQIHLLKPLTRYPALMLRDLILERNLMVLNFACLDGQVPVKNYLARLQQQNRKLRGSENPFAREESPYAWEIITQAITFAKRDHQFRLKFYTPVVRARETFVALMKSEKYRIFNQGKIQRQGRKEDEDSQDGKRQRRDRRKKKQVTFMNETTD
>NZ_AP018172.1|WP_096595448.1|7426690_7427881_-|DUF3596-domain-containing-protein
MYDKPSQGKTPKGSVAIVVSHGRLQLRFRHAGKRHNLSIGLPDTKVNRKAAEGKKAQIELDIASGNFDPTLKKYKPESALTLLTPEITPQIGPPKITEIWQGYIAYKSSSLKETTKGYHNSFTKLFELLGDIQLLDAVKVKASLEKITTVHQTKRALIQLNAACKWGVKHGLIGTNPYVGMANEMPKYRYQLEPKPNAFTEEEREQIIEAFKNHRGNWNGRGYTGISYAHYASFVEFLFLTGCRPSEAIGLQWKHISEDCGFIRFEGSVTTSGNGIPTRVEGSKNNKKRQFSCSERLRKLLVSIKPENPNPESLVFPSPQGKVITYNNFCNNAWDRIVDPIKPDTTPYSCRDTFITLQIIKGIPESVIAGWCDTSVEMIEKHYADSLKMLSLRPID
>NZ_AP018172.1|WP_096594169.1|7428188_7429226_-|hypothetical-protein
MTQSVADKTSIPVKDWRRHTDPPSFWIAVVIGSVTLHLLVFWLLRSYQSSLLWRQQSKSSIPIEVVEISSPTKSRKPDASKPKSVSSKPLSTKLESKNLSKPVVPADQSITKPNPTIQDNNAVAFAEQRQRQLAAQQQRQLAEYRQRQLAVQQQRELAEQRQRQLAEQQQRQLTEYRQRQLAAQQQRELAEQRQRELAEQQQRENAAQTNNQESPSQPSDASGGSLIASLVGQPQQGDRDRHTHSAKIKPSNQPFSKGLEYVKYIEKDSGQPVEFTVVLTISEKGKLEHLAVVDENISEKEKSYYEDFVANQVFNSWEFEPAYDNDPNDPKPSNLIVRIRIQPLP

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Crispr_ID: NZ_AP018172_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_20

8383640-8383879

Orphan

Consensus_repeat	Method
AGATTTTAATTTAAAATTACTTGA	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_AP018172_20

>merge|NZ_AP018172|20|8383640-8383879|CRISPRCasFinder
AACGTTTAATTTAAAATTAATTGACACAACTTTAATGCAGAATAATGCAGCACGAGATTTTAATTTAAAATTACTTGAAAAACTTCCATTAGCAGAGGCGACAGAGCCAAATTTTAATTTAAAATTACTTGAGACTCTTCCTCTGGCAGAGACAACAGCAGAAGATTCTAGTTTAAATGTACTCGATTCAAGTCCAGTTGCAGAGACGAAAGCAGAAGATTCTAATTTAGATTTACTCGA

>NZ_AP018172|20|17|8383640-8383879|CRISPRCasFinder
AACGTTTAATTTAAAATTAATTGA	CACAACTTTAATGCAGAATAATGCAGCACG
AGATTTTAATTTAAAATTACTTGA	AAAACTTCCATTAGCAGAGGCGACAGAGCC
AAATTTTAATTTAAAATTACTTGA	GACTCTTCCTCTGGCAGAGACAACAGCAGA
AGATTCTAGTTTAAATGTACTCGA	TTCAAGTCCAGTTGCAGAGACGAAAGCAGA
AGATTCTAATTTAGATTTACTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096594887.1\|8379685_8380060_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594895.1\|8388984_8390892_+\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470
NZ_AP018172.1\|WP_096594898.1\|8397653_8398844_-\|iron-containing-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|341480
NZ_AP018172.1\|WP_096595499.1\|8386818_8387529_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_AP018172.1\|WP_096595500.1\|8391070_8394718_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018172.1\|WP_096594884.1\|8375776_8375986_-\|transporter	unknown	unknown	gnl\|CDD\|226113
NZ_AP018172.1\|WP_096594892.1\|8384872_8385103_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594894.1\|8387798_8388479_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NZ_AP018172.1\|WP_096594897.1\|8396472_8397657_-\|aspartate-aminotransferase	unknown	unknown	gnl\|CDD\|180317
NZ_AP018172.1\|WP_096595498.1\|8376889_8377468_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341393
NZ_AP018172.1\|WP_096594885.1\|8377930_8378395_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_AP018172.1\|WP_096594890.1\|8381232_8381655_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594888.1\|8380080_8380551_-\|hydrogenase-maturation-protease	unknown	unknown	gnl\|CDD\|99874
NZ_AP018172.1\|WP_096594889.1\|8380566_8381040_-\|NC-domain-containing-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594893.1\|8385125_8386751_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP018172.1\|WP_096594882.1\|8373503_8375099_+\|nickel-dependent-hydrogenase-large-subunit	unknown	unknown	gnl\|CDD\|223451
NZ_AP018172.1\|WP_096594899.1\|8399500_8400022_-\|DUF2518-family-protein	unknown	unknown	gnl\|CDD\|371212
NZ_AP018172.1\|WP_096594883.1\|8375176_8375647_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096594886.1\|8378381_8379668_+\|SagB/ThcOx-family-dehydrogenase	unknown	unknown	gnl\|CDD\|380318
NZ_AP018172.1\|WP_096594896.1\|8394919_8396407_+\|YARHG-domain-containing-protein	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096594895.1\|8388984_8390892_+\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NZ_AP018172.1\|WP_096594898.1\|8397653_8398844_-\|iron-containing-alcohol-dehydrogenase-family-protein	gnl\|CDD\|341480	cd08550, GlyDH-like, Glycerol_dehydrogenase-like. This family contains glycerol dehydrogenase (GlyDH)-like proteins. Glycerol dehydrogenases (GlyDH) is a key enzyme in the glycerol dissimilation pathway. In anaerobic conditions, many microorganisms utilize glycerol as a source of carbon through coupled oxidative and reductive pathways. One of the pathways involves the oxidation of glycerol to dihydroxyacetone with the reduction of NAD+ to NADH catalyzed by glycerol dehydrogenases. Dihydroxyacetone is then phosphorylated by dihydroxyacetone kinase and enters the glycolytic pathway for further degradation. The activity of GlyDH is zinc-dependent; the zinc ion plays a role in stabilizing an alkoxide intermediate at the active site. Some subfamilies have yet to be characterized.	7.25279e-136
NZ_AP018172.1\|WP_096595499.1\|8386818_8387529_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	8.22486e-120
NZ_AP018172.1\|WP_096594884.1\|8375776_8375986_-\|transporter	gnl\|CDD\|226113	COG3585, MopI, Molybdopterin-binding protein [Coenzyme metabolism].	1.00732e-19
NZ_AP018172.1\|WP_096595500.1\|8391070_8394718_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	7.49447e-25
NZ_AP018172.1\|WP_096595498.1\|8376889_8377468_+\|CBS-domain-containing-protein	gnl\|CDD\|341393	cd04630, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.29904e-53
NZ_AP018172.1\|WP_096594894.1\|8387798_8388479_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	3.97674e-07
NZ_AP018172.1\|WP_096594897.1\|8396472_8397657_-\|aspartate-aminotransferase	gnl\|CDD\|180317	PRK05942, PRK05942, aspartate aminotransferase; Provisional.	0
NZ_AP018172.1\|WP_096594886.1\|8378381_8379668_+\|SagB/ThcOx-family-dehydrogenase	gnl\|CDD\|380318	cd02142, McbC_SagB-like_oxidoreductase, oxidase similar to the microcin B17 processing protein McbC. This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.	9.31423e-31
NZ_AP018172.1\|WP_096594888.1\|8380080_8380551_-\|hydrogenase-maturation-protease	gnl\|CDD\|99874	cd06063, H2MP_Cyano-H2up, This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found exclusively in the N2-fixing strains and are encoded by hup (hydrogen uptake) genes. These uptake hydrogenases are heterodimers with a large (hupL) and small subunit (hupS) and catalyze the consumption of the H2 produced during N2 fixation. Sequence similarity shows that the putative metal-binding resides are well conserved in this group of hydrogen maturation proteases. This group also includes such proteins as the hydrogenase III from Aquifex aeolicus.	1.58602e-88
NZ_AP018172.1\|WP_096594893.1\|8385125_8386751_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.000717706
NZ_AP018172.1\|WP_096594882.1\|8373503_8375099_+\|nickel-dependent-hydrogenase-large-subunit	gnl\|CDD\|223451	COG0374, HyaB, Ni,Fe-hydrogenase I large subunit [Energy production and conversion].	0
NZ_AP018172.1\|WP_096594899.1\|8399500_8400022_-\|DUF2518-family-protein	gnl\|CDD\|371212	pfam10726, DUF2518, Protein of function (DUF2518). This family is conserved in Cyanobacteria. Several members are annotated as the protein Ycf51. The function is not known.	3.65778e-88
NZ_AP018172.1\|WP_096594885.1\|8377930_8378395_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.9471e-25
NZ_AP018172.1\|WP_096594896.1\|8394919_8396407_+\|YARHG-domain-containing-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.19664e-69

>NZ_AP018172.1|WP_096594890.1|8381232_8381655_-|hypothetical-protein
MSDIALYRYLPRLPETALQEFTEWCVLEQAKTAGIDFAPDTSKLNNLPPQDYIPKLIDQFMKVKPDPIKAGLVAAIAGKEADKHALSGVAALVDFVSLYVKYLIPKDGSTSEKADALLLEAAQKQCEKLIQIAKKHGVEF
>NZ_AP018172.1|WP_096594889.1|8380566_8381040_-|NC-domain-containing-protein
MVSIYSIPIDCTLGVARHYYLSQDGDFNNSVGWGPSGVEWKGTIKLTEEELKRVHEYTNVFGEYNIHSNNCEMFAWYIKIGKQYSGQTEEIIVTKFGAALVSLVQPVHTVRSIKYLEIEKAIVDNFQANLDKVKQAKLLEEQAARDDFWSRRDAGLL
>NZ_AP018172.1|WP_096594888.1|8380080_8380551_-|hydrogenase-maturation-protease
MLTIIGCGNLNRSDDAVGVIVAQRLQQYLAQNPHPNVRVYDCGTAGMEVMFQARGSKQLIIIDASSTGSEPGAVFKVPGKELEALPEPSYNLHDFRWDNALAAGRKIFQNDFPEEVTVYLIEAANLDLGLELSPAVKHSADLVFEEVAATIRQNNE
>NZ_AP018172.1|WP_096594887.1|8379685_8380060_+|hypothetical-protein
MAKEIYSPEDDSHPMQLTSADIILRQQLEYSISRYFYEACDRTIQSLLSSCRWYFTTHSSVMVLVIECPDPVTNWRVLQKIVPMATILNPIVSSAKIRVCPPESQGIPFEMRVDELAVYRDLAG
>NZ_AP018172.1|WP_096594886.1|8378381_8379668_+|SagB/ThcOx-family-dehydrogenase
MPPSKLSELDYHQATKHSYLSVQIDPNYVDASTQPSVFKVYPKFYRRVKLNLNNPVHSFISLTSTITLEKMYKDGLQKLRVNPSAGALYPTEVYVQIRDIEGIVNGIYHLEVENNCLTLIYELIDDGLESYIIPGKSINGFIFLISCVYYRSSWKYKDRSLRYCWLDSGHHLGAIAASAYIHDQEIQLIFDFDKLALNAALGFENKEFITACAISGEVQEKKIRHLRLQVPFVCGTDYFEANEFVESGYQKTSLQKSRQQKLLHPQFNFDKDKFFQTVWMRRSSRRFYKQSISQENYWRILQHLAQPIPTENFEEIEIYSVIHQVRGITPGLYKGKHLIKAGNFSEKTGYLCINQAIAKDSAVTLFFVSDYINYQTAMQIAGFLGQRVYLVSNFWGIHCSAIGAFYDDETQEFLQTNKDVLYAMAIGV
>NZ_AP018172.1|WP_096594885.1|8377930_8378395_+|ankyrin-repeat-domain-containing-protein
MSSRNQQNLSKTTSQWLRDKGYNLDDLNQPGENGDTALMKATREGIYAVVKELIALGADINIRNNDGNNALWFACFGNYFDLMNLLLAANINIDNQNDNGATVLMYAASAGKTEVVKLLLQHHPNINLKNLDDFKAIDFASNIEVLRILKNASK
>NZ_AP018172.1|WP_096595498.1|8376889_8377468_+|CBS-domain-containing-protein
MTQDVATIRGSASVAEAVKLMRLKELRALIVEPRHSGDAYGIVTETDIVSKVVAYGKDPERMHVYEIMSKPCVVVNPDLDVEYVARLFANTGVWRAPVIQGELLGIISVTDIITKGDFVEKPKLKFVQKELHKAISNARSITANYGADSKRADEAWDLVDELEAEAGYYGAPKPEKTARQLFSEGREYVSVG
>NZ_AP018172.1|WP_096594884.1|8375776_8375986_-|transporter
MEISARNSLKATVKKVVAGSVNSEVTLEIAPGVEVVAIITKSSADKLGLSEGKQAYAVIKASDVLVAVD
>NZ_AP018172.1|WP_096594883.1|8375176_8375647_-|hypothetical-protein
MKSESAILQAEYDIYTAICQERNLFLFHRPDTVFSDYTADDPFHKYHSDRPRFSGAFKYECLRCKGMIEDYEAKNTHEWRLEKRFQVENGYRFVSELEPHESQKARGIFTLSRVGFSESCDYGLVHIAYSACGYYLLFHFNGSVWQRLAYFMSYVV
>NZ_AP018172.1|WP_096594882.1|8373503_8375099_+|nickel-dependent-hydrogenase-large-subunit
MTIKTLDISPVGRVEGDLDVRVEIEDGYVVNAWTHAELFRGFEIILRGKDPQAGLIATPRICGICGGSHLTCASWALDTAWGTEVPRNAILARNLGQIVETIQSIPRYFYALFAIDLTHRKYRNSRFYEEATRRFAAFTGTSYELGVTIAAKPVEIYALLGGQWPHSSYMVPGGVMCAPTLTDITRAWSLLEYFRTNWLEPVWLGCSLERYEQIQTYDDFMDWLDEDRKHRESDLGLYWRMGLDIGLDRYGAGTGKYGTWGYLPHEDKYQNPTIEGRNAATIMKSGVYDSFTDTHTLLDHTFARENTTHSWYDEGTADVHPFDRVTNPIQKNTKDFDNAYSWATSVRHQDFGRLEVGALARQLVAGGKHGESWQHQDGFILDVFKQMGGPSIHVRQLARVHELVKLYRQAEHCLREFKLNDPWYIKPKEKDGRGWGATEAARGSLCHWVEIEGGKIKNYQVIAPTTWNVGPRDGEGVRGPIEEALIGTPIYDSSDPVEVGHVARSFDSCLVCTVHAHDAKTGKELARFRTA
>NZ_AP018172.1|WP_096594892.1|8384872_8385103_+|hypothetical-protein
MPENYHNYLINDSVHLAQSTKDSVYINTFIWFDIIIIHLLLFVAFNAYKKYRATVLRHKVATLEKLWHLEADKKKA
>NZ_AP018172.1|WP_096594893.1|8385125_8386751_+|hypothetical-protein
MKYLFVIWLLIFSLVFPGNALAQIQQPYTLISGLGTHHHPVSTQNPQAQKFFDQGLNLIYAFNHDEAARSFKYAAELDPQLAMAYWGIALALGPNINLDVDSDREQAAYAAIQQAVALSKHASQQEQDYINALAKRYSNNSHAYLYKLAVDYKNAMADLVKRYPQDLDAKTLYAESLMDLHPWQLWTKDGKPGEDTEEILAVLESVLKSEPNHPGANHYYIHAVEASLTPERALESAKRLETLVPAAGHLVHMPSHIYFRVGDYTGAMRSNALAIAQDEAYIQKNHVQGFYPLMYYSHNVHFLAVAAAMAGKYQEAIQAADKLVTNATPFASEVPMIEGYLGTKLLIQTRFSDWDNILKSTVPDDKLVTTKALWYFAHGMANAAKGNIEDAASDRAALLNAQNTIPANATIGMSPASSILDIASNLLDGKIAKAKQDYDSAIKLLETAVAKEDALNYMEPPDWYIPTREALGGVLLAKGDYAAAEKVFRADLQKYPLNGRSLFGLQASLQALGKDNDAKLVQAQFVKAWKNNGTQLLVENF
>NZ_AP018172.1|WP_096595499.1|8386818_8387529_-|ribose-5-phosphate-isomerase-RpiA
MTVAADPVKLMKQEVGKAAAALVKSGSIVGLGTGSTTAYTIQFLGERLQSGELKDIVGVPTSFQSEVLAKQYGVPLTTLDAIDHIDIAIDGADEVDPQKNLIKGGGAAHTREKVVDYLANQFIVVVDSGKLVDRLGSSFAVPVEVIPMAITPVTDAIKKLGGKPELRMGVKKAGPVITDQGNFVLDVRFDSIDDPVNLEKTLNNIPGVLENGIFVNCVDLVLVGEVKDGQPVVRQF
>NZ_AP018172.1|WP_096594894.1|8387798_8388479_+|S-layer-homology-domain-containing-protein
MRQFIGTLSLVVLLQNLPAIHLLQVAEAASSQQSEAIQQVVNAKWMTNSTDGNFYPERLINRAELAAIMVKVFRLDKRQAVSKENLAIPDVPSSHWAFNDIQIALKTDIMKGYRGNLFFPNQKVTKAEALAIFAQAYGVFQFPEETVKEILASHPDATSIPSWARQAIATVISEGFINTDAQGNIFPLRPMTRGDMADVLSKYLQRQQKQPDTPEVPKVPDSPQSP
>NZ_AP018172.1|WP_096594895.1|8388984_8390892_+|1-deoxy-D-xylulose-5-phosphate-synthase
MHLSEITHPNQLHGLSIRQLQQIARQIRDKHLQTVAATGGHLGPGLGVVELTLGLYQTLDLDRDKVIWDVGHQAYPHKLITGRYSNFHTLRQKDGIAGYLKRCESKFDHFGAGHASTSISAALGMALARDMKGEKFKAVAVIGDGALTGGMALEAINHAGHLPKTNLLVVLNDNEMSISPNVGAIPRYLNKMRLSPPVQFIKDNFEEQFKHIPFVGESLSPELGRIKEGMKRLAVPKVGAVFEELGFTYIGPVDGHNLEELIATFQQAHQIPGPVLVHVATVKGKGYELAEQDQVGYHAQNPFNLTTGKAIPSSKPKPPAYAKVFAHTLVKLAEQNPKIIGITAAMATGTGLDKLQAKLPNQYIDVGIAEQHAVTLAAGLASEGMRPVAAIYSTFLQRAYDQIVHDVCIQNLPVFFCLDRAGIVGADGPTHQGMYDIAYLRCIPNMVLMAPKDEAELQRMIVTGVNYTKGAIAMRFPRGNGHGVPLMEEGWEPLEIGKGEILRTGDDVLIVGYGTMVYPSMQAAEILSEHGIQATVINARFAKPLDTELILPLAKKIGRVVTLEEGCVMGGFGSAVAEALLDADVVVPVKRIGVPDILVDHATPDESKAALGLTSRQIAERVLEAFFQKQLSAVS
>NZ_AP018172.1|WP_096595500.1|8391070_8394718_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MPKIDSLFQKFFIPSLLLLANTPVEAQITPDQTLGVEASKITPNILINGANADLINGGAQRGGNLFHSFTEFNINNRQRVYFDNPSGIQNILTRVTGGNSSNILGTLGVNGNANLFLINPNGIVFGQNASLDVRGSFVGTTANGVQFGNQGVFSATNPQAPPLLTVNPSALLFNRVSQNAAIQSNSVAPAGIDPVGFDAFGLRVADGKSLLLVGGNVTIDAGELNAFGGRVELGGLAEPGNVNLLFDGDNLSLQFPENVARADVSLTNQSLVFVQAAGGGDIAINARNLEILGSSGFSAGIGINLGTPETVAGDITLNATGEIKIADAGSGIFNLVRRGAQGSGGNITINSASFSLSDRAQLTTLTLGQGNAGNITIDSGDILLSDFAQMAAVTLGQGNAGNVTLRAKNAISLAGANVFSTVEAGGVGKGGNIDVNAATLSLTNGSQLLTITRGATATRPAGIGDAGNVNVKVTGNVDIAGRVGGFGSGIFSDADVGTVGNGGNITIDAGSFSLRDGAFLQATTSGQGNAGNVRLRVKDGIFLADSNILSTVEAGGVGNGGNIDINAASLSITDSTQVLTITRKPSDTLPAAQGNAGNVNVKVTGAVEIAGEKDGSASGIFSALETGTVGKGGNIFIDAASLLMRDGGQLEASTYGEGIAGNVIVNVKDAVSLTGSADILSTVEAGGVGKGGTIDINAASLSIAEGSQILTIINQAYRGQPPGRGEAGNVNVKVTGGVDIAGQKDDIVSGIVSYINTGTVGKGGNIFIDAASLTLSDRGQLSASTLGQGNAGNVTLQIKDAVSLTGGAYILSTVDAGGVGNGGNIDINAASLSVTDAAQILTVTLSALGDLPAGRGDAGNVNVKVSGAVDIAGARNTFASGIFSTVDKGTVGNGGDIIIDSGSLSLRDGGQLAASTLGQGNAGKIAVNAADFVTISGKSSNFNSGLYVNSESTTGTAGDMIVNSPKITLDNQGTLKAESVSGNGGSINVNSDLLLLRRGAQISTNAGTEQKGGDGGNININSTFIVAAPNENSDITANAFSGVGGNINIRTQSIFGIEARPKPSEQTNDITASSELGVQGQIAITQPEVQPTQGLIELPTELIDASQQIAQICPRSPNAKPLGKFIVTGRGSLPPSPLEFMMGTSIHLPLATLEEQTATLIDYVVPVSNDATPEMIEAQGMVKTANGEIALVANAPQATPTSRLAASVCPVSSQN
>NZ_AP018172.1|WP_096594896.1|8394919_8396407_+|YARHG-domain-containing-protein
MNLLNDRYQVIRTLGAGGFGETFLAEDSYMPSKRRCVVKQLRPIQNNPQIYQLVKDRFEREAAILETLGGGSDQIPALYAYFEADGQFYLVQEWVEGDTLTVKLQQGLFSEIAVQELLVNLLPVLEYVHGKYIVHRDIKPDNIILRHRDGKPVLIDFGAVRESMGTVMNSQGNPTSSIVIGTPGFMPSEQAAGRPVYSSDLYSLGMTAIYLLTGRQPQQIETDPQTAEIMWRQYASHISPMMADILDSAIAYHPRDRYPTARAMLDALQSIANLVNPIPPTQPFVNQSPVVSIPSPPTIPVTPPPINQNTNRNGFVIGSLIAGGLIGASVIISQVLKPSQPIAQTTPTPTETSSPTTSQIPETPVSSPSPIQQETSIPQASVTPTFSNSTNTYTTPSENPTANNYSWLSQRLVTDEDLAGKDGYELDIMRNWIFAIHGRQFDTPGLQDYFNNQPWYQPIYSPKKFPNKLLTSLEQRNVDYIAQYQDRYNLRYFKK
>NZ_AP018172.1|WP_096594897.1|8396472_8397657_-|aspartate-aminotransferase
MSLDWIVPAERIQKLPPYVFARLDELKAKAREQGLDLIDLGMGNPDGATPQPVVEAAIQALQNPANHGYPPFEGTASFRRAITNWYNRRYGVTLDPDSEALPLMGSKEGLAHLAIAYINPGDLVLIPSPAYPVHFRGPVIAGGQVYSLILKPENDWLIDLAAIPDEVAEKAKILYFNYPSNPTAATAPREFFEEIVAFARKYEILLVHDLCYAELAFDGYQPTSLLEIPGAKEIGVEFHTLSKTYNMAGWRVGFVVGNRHVIQGLRTLKTNLDYGIFAALQTAAETALQLPDVYLHEVQQRYRTRRDFLIEGLGKLGWDIPKTKATMYLWVKCPTGVGSTDFALDVLQQTGVVVTPGNAFGVAGEGYVRISLIADCDRLSEVLHRFKQAGIHYS
>NZ_AP018172.1|WP_096594898.1|8397653_8398844_-|iron-containing-alcohol-dehydrogenase-family-protein
MPNQSSTQTLSTQTSNSFLTLTIAPAKVIRGSSILQSAAAEIASLGSRPLIVAGDRTLAITQESLQPFLEQQHLHIAQASYGADCCEASLKSLRKAAKEHKADLIIGVGGGKALDTAKLVAHQLQLPVVTIPTSAATCAAWSALSNVYSEAGAFLYDVALSRCPDLLILDYDLIQTAPQHTLVAGIGDAIAKWYEASVSSGHSQQTLIIGAVQQARVLRDILLQKSATALNEPGSEIWREVVDATVLMAGVVGGIGGAQCRTVAAHAVHNGLTHIAGHGSIHGEKVAYGILVQLRLEEMVQGNQLAAAARQQLLKFYAEIGLPQKLTDLGLGKITLAELQTAAEVALVPTSDIHRLPFKVALEQLMAAMVSTTAPVDSRDTVNRVSVMGVSDEVEE
>NZ_AP018172.1|WP_096594899.1|8399500_8400022_-|DUF2518-family-protein
MLTTADFLQYTQWSGIATLVFAALTVLAFFLKWGIRFRLVGTTGFMLVLTGGLFALSIVPLSRTVIPGAVRYTLVYDNGSTQTVIATSPQITPSELEATLRQAASNLYSYGRLGSRNDNDLTIRARTLIHPEPGTSVPLYLGQIKRTLTQREDPEMAVEIYPEKFAQLPKPTA

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Crispr_ID: NZ_AP018172_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018172_21

8592827-8593165

Orphan

Consensus_repeat	Method
GTTTCCATCAATCATTTCCCCGCAAGGGG-------ATTGAAAC	PILER-CR
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	CRISPRCasFinder
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	CRT

4 spacers

The CRISPR arrays of NZ_AP018172_21

>merge|NZ_AP018172|21|8592827-8593165|PILER-CR,CRISPRCasFinder,CRT
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAACACTGATATTTCGCCTTACGAATCTGGCTTAGGCGCAGTACAAAGTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAACATGTCAGTGACAGCACCAGTAACACTAGTAGGAACGTCGTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAACTTTGCGCATATTAGGTGATCATGTACTCCATTAATTGTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAACACTTGCACGACGGTTGTTATCCCGTCTTTACCCGGCAGTTTCCATCAATCATTTCCCCGCAAGGGGACTAAAAC

>NZ_AP018172|21|11|8592827-8593165|PILER-CR
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ACTGATATTTCGCCTTACGAATCTGGCTTAGGCGCAGTACAAA
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ATGTCAGTGACAGCACCAGTAACACTAGTAGGAACGTC
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	TTTGCGCATATTAGGTGATCATGTACTCCATTAATT
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ACTTGCACGACGGTTGTTATCCCGTCTTTACCCGGCA
GTTTCCATCAATCATTTCCCCGCAAGGGGACTAAAAC

>NZ_AP018172|21|18|8592827-8593165|CRISPRCasFinder
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ACTGATATTTCGCCTTACGAATCTGGCTTAGGCGCAGTACAAA
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ATGTCAGTGACAGCACCAGTAACACTAGTAGGAACGTC
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	TTTGCGCATATTAGGTGATCATGTACTCCATTAATT
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ACTTGCACGACGGTTGTTATCCCGTCTTTACCCGGCA
GTTTCCATCAATCATTTCCCCGCAAGGGGACTAAAAC

>NZ_AP018172|21|11|8592827-8593165|CRT
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ACTGATATTTCGCCTTACGAATCTGGCTTAGGCGCAGTACAAA
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ATGTCAGTGACAGCACCAGTAACACTAGTAGGAACGTC
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	TTTGCGCATATTAGGTGATCATGTACTCCATTAATT
GTTTCCATCAATCATTTCCCCGCAAGGGGATTGAAAC	ACTTGCACGACGGTTGTTATCCCGTCTTTACCCGGCA
GTTTCCATCAATCATTTCCCCGCAAGGGGACTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018172.1\|WP_096595030.1\|8585694_8588016_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_AP018172.1\|WP_096595024.1\|8580557_8581235_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP018172.1\|WP_096595025.1\|8581231_8581519_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096595023.1\|8578855_8580382_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP018172.1\|WP_096595027.1\|8583072_8584593_-\|phenylacetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|224458
NZ_AP018172.1\|WP_096595035.1\|8596328_8596961_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP018172.1\|WP_096595039.1\|8606992_8607511_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372967
NZ_AP018172.1\|WP_096595510.1\|8600318_8603258_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NZ_AP018172.1\|WP_096595041.1\|8611374_8613114_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NZ_AP018172.1\|WP_096595031.1\|8588551_8590231_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP018172.1\|WP_096595038.1\|8604006_8606973_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP018172.1\|WP_096595040.1\|8607653_8611325_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018172.1\|WP_096595033.1\|8593447_8595052_+\|murein-biosynthesis-integral-membrane-protein-MurJ	unknown	unknown	gnl\|CDD\|223800
NZ_AP018172.1\|WP_096595037.1\|8597842_8598841_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_AP018172.1\|WP_096595028.1\|8584705_8585104_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|227786
NZ_AP018172.1\|WP_096595029.1\|8585259_8585634_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018172.1\|WP_096595034.1\|8595487_8596246_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|168293
NZ_AP018172.1\|WP_096595032.1\|8590363_8592517_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP018172.1\|WP_096595036.1\|8596957_8597800_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_AP018172.1\|WP_096595026.1\|8582359_8583052_+\|sugar-transferase	unknown	unknown	gnl\|CDD\|376775

Protein	Function_ID	Function_description	E-value
NZ_AP018172.1\|WP_096595030.1\|8585694_8588016_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	1.71737e-18
NZ_AP018172.1\|WP_096595024.1\|8580557_8581235_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	9.83742e-76
NZ_AP018172.1\|WP_096595023.1\|8578855_8580382_+\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.8176e-44
NZ_AP018172.1\|WP_096595027.1\|8583072_8584593_-\|phenylacetate--CoA-ligase-family-protein	gnl\|CDD\|224458	COG1541, PaaK, Coenzyme F390 synthetase [Coenzyme metabolism].	3.44534e-93
NZ_AP018172.1\|WP_096595032.1\|8590363_8592517_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.92145e-62
NZ_AP018172.1\|WP_096595039.1\|8606992_8607511_-\|hypothetical-protein	gnl\|CDD\|372967	pfam14218, COP23, Circadian oscillating protein COP23. This family includes the circadian oscillating protein COP23 from Cyanothece sp. (strain PCC 8801). The levels of this peripheral membrane protein display a circadian oscillation.	2.36993e-14
NZ_AP018172.1\|WP_096595510.1\|8600318_8603258_+\|GAF-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.78473e-52
NZ_AP018172.1\|WP_096595041.1\|8611374_8613114_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	2.10881e-119
NZ_AP018172.1\|WP_096595031.1\|8588551_8590231_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.77229e-63
NZ_AP018172.1\|WP_096595038.1\|8604006_8606973_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	8.7406e-17
NZ_AP018172.1\|WP_096595040.1\|8607653_8611325_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	2.34271e-23
NZ_AP018172.1\|WP_096595033.1\|8593447_8595052_+\|murein-biosynthesis-integral-membrane-protein-MurJ	gnl\|CDD\|223800	COG0728, MviN, Uncharacterized membrane protein, putative virulence factor [General function prediction only].	4.63675e-114
NZ_AP018172.1\|WP_096595037.1\|8597842_8598841_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	4.16617e-47
NZ_AP018172.1\|WP_096595028.1\|8584705_8585104_+\|transcriptional-regulator	gnl\|CDD\|227786	COG5499, COG5499, Predicted transcription regulator containing HTH domain [Transcription].	9.13273e-11
NZ_AP018172.1\|WP_096595036.1\|8596957_8597800_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	2.39954e-50
NZ_AP018172.1\|WP_096595034.1\|8595487_8596246_+\|hypothetical-protein	gnl\|CDD\|168293	PRK05910, PRK05910, type III secretion system protein; Validated.	0.00513558
NZ_AP018172.1\|WP_096595035.1\|8596328_8596961_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.35482e-43
NZ_AP018172.1\|WP_096595026.1\|8582359_8583052_+\|sugar-transferase	gnl\|CDD\|376775	pfam02397, Bac_transf, Bacterial sugar transferase. This Pfam family represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways.	3.55702e-93

>NZ_AP018172.1|WP_096595032.1|8590363_8592517_+|protein-kinase
MHPVYCSKGHENPAGSRFCLNCGEKLLDTPVNYSIQPGQVLGDRYLIVRQIGQGGFGRTYLAEDVNRFRELCVLKEFSPQVQTAYVLQKAEELFQREASVLYKLQHPQIPRFRENFRINLDGKEYLFLVQDYVEGQTYNSLLNTRRSQGLRFTEAEIRQLLQQILPVLEYIHSLGVIHRDISPDNLILRKLDQLPVLIDFGGVKQVVATVASEYYQPGVVGSPAGATLLGKVGFAPPEQMQTGLVSPHSDLYALAATMLVLLTGKQPQELIDTYTLNWQWDREVSLSPALGQILNKMLSPRPGDRYQSARQVLEALNPQQAISYVPTQPPTQAPTPPTTSETVAIASPRYPSPPVPISSPPPQPTNSWTPTKTFLIVLVTAGIAGVGLWGVNNLLRSDLNGGDPTISPTPTPTATTTPPQYSPAEQQRKDKLRDRRQQLGIDNNFYVNLVNQLFWEQNPSLKGRTLSDRPEDENLRAQWDRLAGEVLDKLAQLSTKARQQLGTYTSAERDRWKVEVNQVNVGSRSLYDLGDAAFFAAFPTQRNKDFVNQPIGQVWYGFVSDKLSAILAGSAFQKIVFDQGATSKTVSGNLSPSNGKVFIAGLAKEQSLEVNLKANSKVLLSIYSPSGKIKFLEDSTQRSLSIKLPEDGFYEFVVVNTGSQATDYQLTITAQTPTPPTPTPTVTDTPTPTPTVTTTPTPTPTVTDTPTPTPTPTSNSQ
>NZ_AP018172.1|WP_096595031.1|8588551_8590231_+|serine/threonine-protein-kinase
MQVYCTKQHVNNGSNRFCTHCGEPLPLPVGQLVDKRYKIIRQLGEGGFGRTYLAEDRNQSNQQCVLKEFAPQVQEQQDLQKAKELFEREANVLKKLQHPQIPKFHASLQEKLGGRDFFFLVQDYIDGDNYRQLLEQRQSQGQTFSEEEVLTLLEKILPVLSYLHSKDVVHRDISPENLIWRRSDNLPILIDFGGVKQLPASQGFWFTQLAVNHTLLGKKGYAPEEQLRQGKVFFSSDLYSLAVTALVLLTGKEPQMLYDSYQGIWLWGKEIKVSPKLEAVLKKMLAYQPNARYQNASQVLKDLPSKVATKQPNPYITKIKTMVVAPGRKQTNQIISKIHSKTQLIANKMPLPAWLRPFAVSLGGTAVVVLVGVGSFAVVNGIIRSISSISLPKIPSISLPASKPVSDKGTSRISQILSRRQQLEIPEGFFIRMVDNLFYSQKPELQGRSLTSKPEDAALRDEWYGIAENLLQKLEQANLSSAARRKLGSYSQRDYDTWRQQARNGQFGNYTINQLTKDTYEQFDRLFPGQPRGKLNQQTYGQIWYAIAADRVSKVQSGN
>NZ_AP018172.1|WP_096595030.1|8585694_8588016_+|tetratricopeptide-repeat-protein
MPLSGVVEFVGRGEELQNLHKLLQQNQQVAIAAIAGMGGVGKTELALQYAIKYRDNYQGGICWLLPKSGDIGVQIVQFARTQLDLNPPTDVDLPAQVQFCWWRWREGEVLLVLDDVADYQEVKPYFVSLSSRFKILITTRQHWGRIAELSLDVLQPEAALELLKSIIGVDRFERENQRNPQVALQLCEWLGYLPLGLELVGRYLEQDPDLTLERMLSRLQHDGLRDKSIYAAEATMTAKLGVEAAFNLSWQQLDAATQELGCLLSLFATAPITWELVGKVLEAYRALTRNSNSVFKGFQKLFTFFSKQNHQQSDKSFHLNTDISLEEAKINLLRWHLLQRQGEGIYQLHPLLREFFQSQLKSLEPAEEFKRSFCKVMIAVAKTIPQTPTLEQINYVTPAIPHITEVADNLIKDVNDDDLIWPFIGNARFYNGQGLYDKAAPWYQQSLEVTKNRLGESHPLVATSLNNLAELYRSQGRYSEAEPLYVQALELWRRSLGESHPLVATSLNNLAILYLSQGRYSEAEPLYVQALELRRRSLGESHPLVATSLNNLAELYRSQGRYSEAESLYVQALELRQRSLGKSHPLVATSLNNLAELHHSQGRYSEAELLSVQALELLQRSLGESHPLVATSLNNLAALYRSQGRYSEAEPLYVQALELRRRILGESHPDFATSLNNLAGLYKSQGRYSEAEPLYVQALELRRRILGESHPDFATSLNNLAGLYDSQGRYSEAEPLYVQALNIFERQLGVNHRHSVTVRGNLAYFRAQFSSEQ
>NZ_AP018172.1|WP_096595029.1|8585259_8585634_+|hypothetical-protein
MEPVTLTAAAIATLVITKAFEKTGEILGEKALEEGGKLFSLLKDKAPNTAAAIELAQTQPLDYGQAYLIGQQVEEAAKKDDEIAEAVAALAKEAQPQLTQTIENYQGINIKGGTNTISGNTFNF
>NZ_AP018172.1|WP_096595028.1|8584705_8585104_+|transcriptional-regulator
MTRTFNPESYGKLLAEYQPKTIITEEENEAAIRLALTLEHRPNRTPEEDMLLELLLTLIEKFEETHYPIPQGAPNSMLIHLMDAKDVTTEALANVIGSLEVVREIINGDRTISKTQAEALANHFNVDASLFI
>NZ_AP018172.1|WP_096595027.1|8583072_8584593_-|phenylacetate--CoA-ligase-family-protein
MNSTSQQQRAITAFGDFLSTPLDTLLQQHLETPKESAILALFRDVAAHVPAYKAFLAERGIDPATIQSLEDFQNLPAIAKENYISRYPLADLCRNGKLSECDMIAASSGSTGKPTFWPRFFADELQIATRFEQIFHDSFYADTRRTLAVICFTLGTWVGGMFTTNCCRYLASKGYPVTVITPGNNKEEILRAVQELALGFDQVVLLGYPPFLKDVIDTGIARNVQWQQYHIKLVMAGEVFSEEWRSLVGERIGSQNPCYDFASLYGTADAGVLGNETPLSICIRRFLAQHPDAAKALFGESRLPTLVQYDPISRFFEVQDGTLLFSGNNGIPLVRYNILDTGGVINYDAMLKFLAQWGFDPLQDEHLCVDNQATRGIRALPFVYVFGRSNFTVSYFGANIYPENVTVGLERSPIPDWVTGKFVLQVKEDADKNRFLSIVVELAPGVEASEDKRVAIASSILSQLLRLNSEFANYVPKEYQMPQVALAPTGDAEYFPIGVKHRYTRK
>NZ_AP018172.1|WP_096595026.1|8582359_8583052_+|sugar-transferase
MPKRSHNHSIHGSLIDEAYKSHLASLPVHPSVTSKVKRIIDILGAAIGLGITGLVIIPVTIAIQLDNPGPIFYSQIRCGLNGKSFRIWKFRSMVVGADRHKHLVKNEAKDHHIFKNQNDPRITRVGRFLRRTSIDELPQFWNVLRGEMSLVGTRPPTPDEVMHYSNHHWQRLNVKPGMTGEWQANGRSSIKSFEEIVRMDLDYQYKWSITYDVSLILKTLKVVFNRNGAF
>NZ_AP018172.1|WP_096595025.1|8581231_8581519_-|hypothetical-protein
MIVGSNITTVQRVSSYCLKKSPHVLPYYGIPTNEEMNLFAPDILVLCLPIPESFQHQIRQPYILWSDNLTFADLRLPFVNNPKDLYELLCEVVPV
>NZ_AP018172.1|WP_096595024.1|8580557_8581235_+|response-regulator-transcription-factor
MADSVEFKTIKVLVVDDHPLIRRGMKGQFSLETGFTVVGEAEDGAQAIKLAAQLQPDVILMDIDLPDIDGITATQKIKSDQTAIRILALSAFDDDTQVVGMLAAGADGYCLKSIKWEQLVAVIQLVLQGGAYLDPSIAQKVARMLKPSFVSQDTRASEGNQRPILSSREREVLKLIAQGYSNQEIADELYLSLGTVKSYVRMLLNKLSVDDRVQAAAIAVREGLI
>NZ_AP018172.1|WP_096595023.1|8578855_8580382_+|sensor-histidine-kinase
MILAISLLSLKAKSNQSNIRLLTRVYLSFGLLVCFLVLQQGWNFWLLFLNQNAANCITNTLQVERETQHLLNELRDEERATQQPYYSPMRTTFSNNLDRLSHLLQDMPTLKTQQIHKIKYLYNNWHSQVRQRRILEPIHSLTTEEQVSLISIINNIQLLSEQYEQLLQERRHDLLQLYRIYTVVNIASTILILLVISGNIYFLYQRVELPLRNLMRIGELWQAGQLEARLGYASADEIGRLTEILNSMANKASQRQQNLKAKNQKLEDLISALSHDLRTPLLATRNTLDCMLKGAFGYVSHSFKEVLEEYRQANEDLLQLVETLLDISRYENTNKTHNKLICNSLNWENILAKVITLIESTSDKKIIFTCKISPSLPAVYANSSEIQRVLQNLLDNAVRVSQPNTEIVLEVVTLGDTQIKVSVQDRGPGITAIEKEKLFHRFIQGRGRRGKSGLGLYLCRQIIQNHGGLIGVDSVLGEGSTFWFTLPVAKEKAEIQNKEQQILDKHVL
>NZ_AP018172.1|WP_096595033.1|8593447_8595052_+|murein-biosynthesis-integral-membrane-protein-MurJ
MTKQDQKPTRSFAGIAGIVAIATLISKIFGLVRQQAIAAAFGVGAAATAYSYAYIIPGFLLILLGGVNGPLHSAIVSVLAKRKQEEAAPLVETVTTLVAGILLIVTLAQVVFADTIVDFVGHGLKETTRAIAIQQIRIMAPMALFSGLIGIGFGTLNAAHQYWLLSISPLLSSITVVVGIGILALQYGKNIILPEYAYIGGMVLAWGTLAGAVLQWLVQLIVQWRLGLGTLRLRFDFKSPAVREVINIMTPATISSGMMPINVATDLYFASPIPGAAAGFNYANLLVQTPLGIISNIILLPLLPMFARLAAPENWHDLKLRIRQGLLLTAFTMLPLGALMVALSVPIVQVVYERGAFKQEATQLVSSLLIAYGIGMFAYLGRDVLVRVFYALGDGQTPFRISAFNIFLNIVLDWFFVKPFGAPGLVLATVGVNCSSMLMLLWLLDRKLNGLPWREWSLPIIGLTAGSIVSGVASYGALVGCRQVLGKENLLILLIELSVAGLVGLGVFAIFASWLKIPEINSFVSRMRQRFLKQ
>NZ_AP018172.1|WP_096595034.1|8595487_8596246_+|hypothetical-protein
MASQQESKNKQSETASKKEGATATKTNENNNLELDSLFEALEGDLTSLDSEAAVDLIDQWYSSLHKAKEPEIKEIANSLKNLKQLVKSGKATGHEIGEVLIEIGDQTSDFGSDANKELKTPLQRLGKQLSKIGVSLGKQEDREQIEQIDSLVETLEGDLTEIEPEVAQGAIDTWYTLLHKSEDENLQEIANGLKELKQLLKRKTAKGADFAPVLTKLGEQTEQAGAEAARGFKGPLKRLGKLLSKAGQSLAE
>NZ_AP018172.1|WP_096595035.1|8596328_8596961_-|response-regulator-transcription-factor
MIRVLVVATSPVVRAGLSAVVSSNSQLNVVGSASNLDTAIAEVGQLQPDVILLDLSSNAQASMWEKLLLFQEEQYPVGFLTIAEEIESIDIEAAFRSGVRGILPNDSRESEIIAAVIAIADGLVVLHPDFLDLLPMREKVATTPVQTLTPREIEVLEMLGSGLGNKAIAKHLQISEHTVKFHISSIFQKLAVSTRTEAVTVGVRLGLIML
>NZ_AP018172.1|WP_096595036.1|8596957_8597800_-|PDZ-domain-containing-protein
MITTKITNLTDELATLAAKLRHSTVKVQSNSQGVGSGVIWQSDGLIITNAHVATSNQAKVELADGRVFDAVRTHFDPQQDLAALKITATDLHTATIGDSDALRVGELVLAVGNPLADSGAVTLGIIHAYHQKAVMADIRLYPGNSGGPLADCLGRVVGINTMVVNGLAVAIPSLAVNRFLQAPNRPRLGVTLQPVWVGRRNLGLLVLSVLPESTAAIAGVEIGDVLIGISGQLFTNSDDLGKYLQQHQNQESIPLQLWRSGQQLVVYVRLQSDKTAVEAT
>NZ_AP018172.1|WP_096595037.1|8597842_8598841_-|PDZ-domain-containing-protein
MSSLLELSNSLADTVEQAGNAVVAVNAGTRISSSGIHWRQGIIVTSDESLQRYDEITVTLFDGRSVAATHLGHDSSTDIAVFQLQDGETPVAKIGDATTLKIGHLVLGIARSNAGELRAALGTVSVISGAWRSMSGGNIDQFIRPDMTLYPGFAGGALVDAAGYVVGMNTSGRRGTALTIPAATVNRVVDQLLAKGHIARGYLGVGMQPVRLPNNLIAALSLTSATGVIVVNVEPAGPADHAGVLLGDVLVAFDGTTVSDTGDVMALLNSSDRVGKTVPLQVIRGGVLVELAITVGERPFEQYSNQEDSEKSSDRSHHRRGRHGRRGSSHSR
>NZ_AP018172.1|WP_096595510.1|8600318_8603258_+|GAF-domain-containing-protein
MKSTYHPPALNSPFTLDIARGSAAENIANTQNNKSTSHTEKKSLLQRFYNLSLSRKQLIALIVSEVITILGLSVVSRWLISHNFQNTLLEQAKSELAVTDINYNIQIDEMGLVSLSQSDNPTIIKSAILHSSGQAVSQRLQAEVKQILENEIKAGKIDYATLVGKDFKIIANANANREAEIFNPDNLVSEVFNNLQQMKATRIISASELSQELPLLANALNNQDALIRYTVTPVKNPTTQAVVGALVTGDIVNGKDQIVRDTLKATNGGYSAVYLRQPTGEFTLATALEQSKSQNLDRAQANIKLPQAAKSFLEAAATAKGNVVTTKLNLGNKTYAMAAKAVPNTIVETDEQSIANFDEKSVAILVRGTPETALSQLLQNNFWLELIAIILALTLILFWTFVLKRGVVQPIQQLGQTAKKFNQGDRAARTEIFANDEIGQLANTFNQIADRMTQQLIRQENEAKLAQVVNEITARFRGSLNTTHILNVAVTSIREAIAVDRAIVYRFDDNWQGKIIAESVGRDWPKALGKEIADPCFASDYVHKYQQGRVQALENIYAAGLTECHLHQLEQFAVKANIVAPILLDNKLYGLLIAHQCSSTRNWQQLEIELLKQVAIPVGYALEQSYLLEQIETARSRAETAAIEQRQQNEALQEQILTLLRDIEGASQGDLTVRSEVTSGELGTVADFFNSIVESLRAIVTKVKTSAIQVNTAIGENEVAIRQLAAKALQQADDISLSLVSVDQMKSSIESVAENARKAALVAHQASCTAEENGQAMDLAVQNILKLRSTIGDTAKKVKRLGESSQQISHVVALINQIATQTNFLAINAGLEATRSGVEGEGFAIIAEEVASLAARCSDATQEIAQIVAKIQRETSEVVTAMELGTNQVVEGTNIVEQAKSSLSQILDVSKQIDDLVQSISWATSSQVETSQAVSKLMQEISQVSTLTSNYSRLASQSLKQTFEISQELQAAVETFKVN
>NZ_AP018172.1|WP_096595038.1|8604006_8606973_+|tetratricopeptide-repeat-protein
MKPLGKILQQADLISSEQIEIALKEQSQFNGSRLGEILASHGWLKQETADFFSQQWPAVLEQKPKQSLGKYLQDAGLLNEQQIATILAEQPDKKLRFGELAVLKGWLKPTTIKFFLENLALEEQMQHDEISTPNSLTQTEQLQELILQQKNNIRAANSIEQSSFDSQLGEQESSMLRLFSRSTIRLFKLDEKASRPDVVMTEVLSWTNGQPILTQKLCRMLADSPGFIPAGAEATTLQHLVQTRLIYHWETQLAAEHLQRIRESILQNQQCDPLSLLELYQQILQQGEIPTNNSSEQIELLQIGLVKQRQKQLRVSNRIYQSVFDANWVQQEAAKLRLLSHNTIKLFKLEEKASCPEILMSAVLFWTEGQPILTQKLCRLLAESQEFIPAGAEAATVQQLVKTCLIDSWETQLAAEHLQGIRESIINNQQCDPLYLLELYQQILQQGEVPTNNSPEQAELLRLRLVVQQQDQIRVANRIYKLVFDTNWINRESARLRLLSRGTIQLFKLDEKAISPETVLSEILFWTDGQPILTQKVCQLLAESQEFIPAGAEAATVQQLVKMRLINNWETQIASEHLQEIHLGIIHNRQCDPLLVLEIYQKIWQQGEVPINASREQGELLRFGLAVQHQDKLKLGNRIYQLVFDRAWVERELEKILLPSLAKTAIYEPTPSANTLNVSNTYTPPEPGAAKRFWVLLLIAGLMVCGSGLMVLGFSLFRWLQVETIFKRGNELLHQGEYQKAIAKYNKLLELDSNYYQSWTNRGYALAGLKDYNQMLESCTTATIINPEAVYAWNCRGEALYNLKQYNEAIAAFDKAIMLNAKDPVFWINKTEALLALKQPDTALITVNQAIELLKEVWEAERKEANAKELAIGFTYQAKVLSQKQEYEASLKAYEQALKYNPQYFAALRGKGLALQALKRDDRAIAQFYFLLERHQLTNPQKAEIWYYLGLSLCEFRQYEKAIAAFDRSLKLKPDYAAAKQGKQACYQ
>NZ_AP018172.1|WP_096595039.1|8606992_8607511_-|hypothetical-protein
MNKWQSWATRGTVPILVLGTIAALSQPSTASNVQVTCKTNASTPTVIVTLNREGKTQEHAILKFLPKYFSAADALQNCQNTAGSLQAVYDTGNYKYLTTDKLNDRPVVCAVERRGIGCNHYSAQVLFSFKPIENPSQAFYEMLGKDFKQAQRPDVRTISRTYTDTKPFWWPF
>NZ_AP018172.1|WP_096595040.1|8607653_8611325_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MKQVPRQIFCLSSAYICCLIAASPGLAQISSDNTLPGNISQSGNIFEITGGAQVGNNLFHSFREFSVPTGGEAFFNNATNLTNITNIISRVTGGSISNIDGLIRENYGANFILINPSGINFGANAQLNIGGSFLASTANSVKFADGAEFSATDTSVSPRLTISVPVGLQFGQNPQAIRLQGQGHNLSLERPIFSPFTRGSTTGLKVQPGNTLALVGGGIISEGGTLTAEGGRIDLGSVAGGLVSLNPSSQGWNLSYQGVTNFQDIALSQKALADTSGAGSGSIQLQGRNISLRDGSVALIQTQGAQAAGGINVNASESLALIGTTATGQISSNLFTETLGAGKSGDINVVTPRLLLQDGAAISAATYTPAPGGNIDIKAADSVQVIGFSSINPSRFSNITAATFGAGNAGTLTVTTQQLTALSGGNIASVTGGKDGIGSGGNVTVNASKLVELIGVTPFVFTPSQITAGTGGPGKAGSVTVNTERLVVKDGGRVDASTLASGPAGSVTINAKDAVEVSGTVPGSVNPSLIVSSANIVDPSLQQLLELPAVPSGNSGDVTINTGKLTVADGAELTVRNDGKGNAGTLQVNAGSVLLNSGGKITADNLGSGSGGNLRIETGKLTISDRAFLSASTFGNGTGGDINLRAADSVEMLGTGFEEMQGIFQVGALAGTLKPTDRGTGIFIETVGTGASGKLTIETPFLLMRNGAIVSNLTFSNGVGGNLNIRASELVEATGSAIQTGNTIGSTGTAGNIKIDTKQLRLQDGGNIVSATLGNGLGGNVEIKATDAVQIQRTPPTAAILTGIYTNTTFGTGKGGDITIDTGKLFIENGVIGSNTGASLPTLVIPFGGPGGNVIVNASDSVEIAGILPDPRFPSGLGTTGFSPSRSGDLTISTKKLILRDGADASTATLGAGQGGTLTVNASESIELSGTQIGNLTLGGLSAAAGRVNSPELKVTGASGDINLFTDKLIVRNGAKIGVESLGQGNAGNLKVVANSIRLDNQGSISAATTSGEGGNISLQTHSLLMRHNSQISATAGGNANGGNINITGFSPTNFVALLEGSKITADAFQGAGGNISINTRGFFVCPTCQITASSQLGVAGQISINTPEAENNFEVIDLPQEVAKPEQVVAQACRASRRENESEFTITGRGGLPPRPSEQLSSGALISFEPAGASAATEVQNSSQLPLPARGWYVNAQGVVVLASQAPTPSPYGSGLSSANCQ
>NZ_AP018172.1|WP_096595041.1|8611374_8613114_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MQECSLKSGVRLSVLYPYLLFLLVLSSTNSAYAQPNPVTPKPPEQLPPNPLPPTNAPIEIPPSAPPTPEEVQDIPGTITVQKFEFVGNTAFSQRELESAIANFTGKPITFAELLKAANQITELYVKKGYITSGAYIPAQEFRSGIVKIQVVEGSLEDIQVNVIKGRLHPNYVRSRIAIATGKPLNINRLQEALQLLQLNPLIESLDAELTAGTRPGVNSLTVAVKGARTFTTQLNLNNNRNPSVGSFERGITISEASLLGLGDRFTFAYKNTDGSNSFEGGYILPINARNGSIGFNYRITDNRIIEPPFNNLDIEVNSREFELSFRQPVLQKATPEVSQELTLSLTAARRESNSSIQGVDFPLFPGADNQGETRISELSFAQEWLQRSRQEVLAARSEFNLGVGAFNATINNNEPDSRYFLWRGQLIYLRLLSQAKGQTAIAPTLLLRSNMQLASDSLLSIEQFSLGGQGTVRGYRQDALLTDNGIFASAELRLPIARFPEVQGTLQVAPFIDIGTVWNTGRENPKPNTIAGTGFGLLWQMGDRFTARLDWGIPLVSIDSSKRTWQENGVYFQLEYKAF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP018172_6	6.1\|2591304\|46\|NZ_AP018172\|CRISPRCasFinder	2591304-2591349	46	NZ_AP018172.1	2592100-2592145	2	0.957

1. spacer 6.1|2591304|46|NZ_AP018172|CRISPRCasFinder matches to position: 2592100-2592145, mismatch: 2, identity: 0.957

taatggagcacgggtgagtacagatatgcgtggacaaggagatgga	CRISPR spacer
taatggagcatggatgagtacagatatgcgtggacaaggagatgga	Protospacer
**********.**.********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	KR131710	Fusobacterium phage Funu1, complete genome	1140-1170	6	0.806
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP023246	Bacillus cereus strain HBL-AI plasmid unnamed1, complete sequence	71221-71251	6	0.806
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP042875	Bacillus cereus strain 09 plasmid unnamed1, complete sequence	165074-165104	6	0.806
NZ_AP018172_4	4.1\|2019151\|26\|NZ_AP018172\|CRISPRCasFinder	2019151-2019176	26	NZ_AP019800	Vibrio rotiferianus strain AM7 plasmid pAM7, complete sequence	39820-39845	6	0.769
NZ_AP018172_20	20.4\|8383826\|30\|NZ_AP018172\|CRISPRCasFinder	8383826-8383855	30	NZ_CP045339	Vibrio sp. THAF190c plasmid pTHAF190c_a, complete sequence	548200-548229	6	0.8
NZ_AP018172_1	1.4\|745139\|36\|NZ_AP018172\|PILER-CR,CRISPRCasFinder,CRT	745139-745174	36	NZ_CP037443	Klebsiella sp. PO552 plasmid p2, complete sequence	26799-26834	7	0.806
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP008811	Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence	16548-16578	7	0.774
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	MT773556	Myoviridae sp. isolate BML_4 genomic sequence	195366-195396	7	0.774
NZ_AP018172_14	14.4\|4961548\|32\|NZ_AP018172\|CRISPRCasFinder	4961548-4961579	32	NZ_CP045959	Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532 plasmid pAUSMDU00010532_01, complete sequence	53862-53893	7	0.781
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP024404	Borrelia miyamotoi strain Izh-4 plasmid pIzh4-lp13, complete sequence	1668-1698	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP024220	Borrelia miyamotoi strain Izh-5 plasmid pIzh5-12	11559-11589	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP024343	Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-8	11558-11588	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NC_018952	Staphylococcus aureus plasmid pWBG747, complete sequence	33542-33572	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP014063	Staphylococcus aureus strain FDAARGOS_159 plasmid unnamed, complete sequence	13450-13480	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP024365	Borrelia miyamotoi strain Izh-16 plasmid pIzh16-10	1685-1715	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NC_013326	Staphylococcus aureus plasmid pWBG746, complete sequence	14687-14717	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP024386	Borrelia miyamotoi strain Izh-14 plasmid pIzh14-11	11598-11628	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	MN693193	Marine virus AFVG_25M440, complete genome	50708-50738	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NC_024215	Lactococcus phage P078, complete genome	2085-2115	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NC_024208	Lactococcus phage P118, complete genome	2085-2115	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NC_024214	Lactococcus phage P162, complete genome	2085-2115	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NC_024203	Lactococcus phage P092, complete genome	2085-2115	8	0.742
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	LR215720	Staphylococcus phage Stab23 genome assembly, chromosome: I	32187-32217	8	0.742
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024574	Klebsiella pneumoniae strain INF274 plasmid unnamed4, complete sequence	7422-7453	8	0.75
NZ_AP018172_16	16.1\|5529989\|34\|NZ_AP018172\|CRISPRCasFinder	5529989-5530022	34	NC_029065	Pseudomonas phage VCM genome assembly VCM, chromosome : 1	33712-33745	8	0.765
NZ_AP018172_18	18.1\|6744115\|32\|NZ_AP018172\|CRISPRCasFinder	6744115-6744146	32	NC_020157	Anabaena cylindrica PCC 7122 plasmid pANACY.02, complete sequence	39557-39588	8	0.75
NZ_AP018172_18	18.1\|6744115\|32\|NZ_AP018172\|CRISPRCasFinder	6744115-6744146	32	GU943040	Uncultured phage MedDCM-OCT-S09-C28 genomic sequence	14263-14294	8	0.75
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP009059	Borreliella afzelii K78 plasmid lp54, complete sequence	18868-18898	9	0.71
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_LR214999	Mycoplasma conjunctivae strain NCTC10147 plasmid 3	28802-28832	9	0.71
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	LR214965	Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 11	18393-18423	9	0.71
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	NZ_CP046807	Vibrio alginolyticus strain 2439-01 plasmid unnamed1, complete sequence	43917-43947	9	0.71
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	MT840189	Bacteriophage sp. Joined_contig_348 genomic sequence	5338-5368	9	0.71
NZ_AP018172_1	1.8\|745437\|31\|NZ_AP018172\|CRISPRCasFinder,CRT	745437-745467	31	KY794643	Staphylococcus phage vB_Sau_S24, complete genome	131399-131429	9	0.71
NZ_AP018172_2	2.1\|1028633\|35\|NZ_AP018172\|PILER-CR,CRT	1028633-1028667	35	NZ_CP043555	Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence	41820-41854	9	0.743
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP043555	Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence	41820-41851	9	0.719
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP042875	Bacillus cereus strain 09 plasmid unnamed1, complete sequence	475499-475530	9	0.719
NZ_AP018172_7	7.5\|2730316\|40\|NZ_AP018172\|CRT	2730316-2730355	40	NC_014533	Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence	418075-418114	9	0.775
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024195	Klebsiella pneumoniae isolate KSB1_5D plasmid unnamed4, complete sequence	1539-1570	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP023842	Klebsiella pneumoniae strain 4/1-2 plasmid p4_1_2.3, complete sequence	6628-6659	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP029585	Klebsiella pneumoniae strain DA33140 plasmid pDA33140-9, complete sequence	4542-4573	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024044	Klebsiella pneumoniae strain QS17-0029 plasmid pMRSN479404_4.7, complete sequence	873-904	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024560	Klebsiella pneumoniae strain INF164 plasmid unnamed4, complete sequence	1150-1181	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024532	Klebsiella pneumoniae strain INF157 plasmid unnamed4, complete sequence	4034-4065	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024525	Klebsiella pneumoniae strain INF158 plasmid unnamed4, complete sequence	3291-3322	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024553	Klebsiella pneumoniae strain INF163 plasmid unnamed4, complete sequence	3480-3511	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024574	Klebsiella pneumoniae strain INF274 plasmid unnamed4, complete sequence	2752-2783	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP021700	Klebsiella pneumoniae strain AR_0158 plasmid tig00003569alt, complete sequence	7346-7377	10	0.688
NZ_AP018172_2	2.9\|1028636\|32\|NZ_AP018172\|CRISPRCasFinder	1028636-1028667	32	NZ_CP024567	Klebsiella pneumoniae strain INF278 plasmid unnamed4, complete sequence	2669-2700	10	0.688
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448960	Streptococcus phage Javan492, complete genome	30812-30845	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448973	Streptococcus phage Javan522, complete genome	32224-32257	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	NC_004585	Streptococcus prophage 315.2, complete genome	31530-31563	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448966	Streptococcus phage Javan508, complete genome	31385-31418	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448772	Streptococcus phage Javan483, complete genome	31397-31430	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448778	Streptococcus phage Javan493, complete genome	31864-31897	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448962	Streptococcus phage Javan496, complete genome	21856-21889	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448793	Streptococcus phage Javan523, complete genome	32033-32066	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448954	Streptococcus phage Javan476, complete genome	30420-30453	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448975	Streptococcus phage Javan526, complete genome	32646-32679	10	0.706
NZ_AP018172_2	2.12\|1028861\|34\|NZ_AP018172\|CRISPRCasFinder	1028861-1028894	34	MK448782	Streptococcus phage Javan501, complete genome	35004-35037	10	0.706
NZ_AP018172_2	2.15\|1029089\|33\|NZ_AP018172\|CRISPRCasFinder	1029089-1029121	33	KT070867	Bacillus phage PBC2, complete genome	157247-157279	10	0.697

1. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to KR131710 (Fusobacterium phage Funu1, complete genome) position: , mismatch: 6, identity: 0.806

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gtatcaaaaaaagaacaaactagagataaag	Protospacer
 * ** . **************.********

2. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP023246 (Bacillus cereus strain HBL-AI plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
ttttctgtaaaataacaaactataaaaatac	Protospacer
************ ********* *.* * *

3. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP042875 (Bacillus cereus strain 09 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
ttttctgtaaaataacaaactataaaaatac	Protospacer
************ ********* *.* * *

4. spacer 4.1|2019151|26|NZ_AP018172|CRISPRCasFinder matches to NZ_AP019800 (Vibrio rotiferianus strain AM7 plasmid pAM7, complete sequence) position: , mismatch: 6, identity: 0.769

gctatcaacaaagtcgattgatcaat	CRISPR spacer
gctatcaacatagtcgattgaaagcc	Protospacer
********** **********  . .

5. spacer 20.4|8383826|30|NZ_AP018172|CRISPRCasFinder matches to NZ_CP045339 (Vibrio sp. THAF190c plasmid pTHAF190c_a, complete sequence) position: , mismatch: 6, identity: 0.8

ttcaagt---ccagttgcagagacgaaagcaga	CRISPR spacer
---aggtctaccagttgcggagaagaaagcaga	Protospacer
   *.**   ********.**** *********

6. spacer 1.4|745139|36|NZ_AP018172|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037443 (Klebsiella sp. PO552 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.806

ctactgctgaagcgattggagctaatgcactaaaag-	CRISPR spacer
ttactgctgaagccattgcagctaatg-attacaacc	Protospacer
.************ **** ******** *.** **

7. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP008811 (Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence) position: , mismatch: 7, identity: 0.774

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
aaatttttaaaagaaaaaactatagataaag	Protospacer
   *.* ******** ****** ********

8. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to MT773556 (Myoviridae sp. isolate BML_4 genomic sequence) position: , mismatch: 7, identity: 0.774

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
ccttcaacaaaagaagaaactacagataaag	Protospacer
..*** ..******* ****** ********

9. spacer 14.4|4961548|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP045959 (Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532 plasmid pAUSMDU00010532_01, complete sequence) position: , mismatch: 7, identity: 0.781

gtctcgattatcaatttaagtgtttggtacaa--	CRISPR spacer
ttctccatgatcaatttaagtgtt--gtactttt	Protospacer
 **** ** ***************  ****

10. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP024404 (Borrelia miyamotoi strain Izh-4 plasmid pIzh4-lp13, complete sequence) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gattctctaaaagaacaaattaaagaagata	Protospacer
  **** ************.****** .* .

11. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP024220 (Borrelia miyamotoi strain Izh-5 plasmid pIzh5-12) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gattctctaaaagaacaaattaaagaagata	Protospacer
  **** ************.****** .* .

12. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP024343 (Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-8) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gattctctaaaagaacaaattaaagaagata	Protospacer
  **** ************.****** .* .

13. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NC_018952 (Staphylococcus aureus plasmid pWBG747, complete sequence) position: , mismatch: 8, identity: 0.742

ttttctg------taaaagaacaaactaaagataaag	CRISPR spacer
------ggagaactagaagaacaaagtaaagataaag	Protospacer
      *      **.********* ***********

14. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP014063 (Staphylococcus aureus strain FDAARGOS_159 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

ttttctg------taaaagaacaaactaaagataaag	CRISPR spacer
------ggagaactagaagaacaaagtaaagataaag	Protospacer
      *      **.********* ***********

15. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP024365 (Borrelia miyamotoi strain Izh-16 plasmid pIzh16-10) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gattctctaaaagaacaaattaaagaagata	Protospacer
  **** ************.****** .* .

16. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NC_013326 (Staphylococcus aureus plasmid pWBG746, complete sequence) position: , mismatch: 8, identity: 0.742

ttttctg------taaaagaacaaactaaagataaag	CRISPR spacer
------ggagaactagaagaacaaagtaaagataaag	Protospacer
      *      **.********* ***********

17. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP024386 (Borrelia miyamotoi strain Izh-14 plasmid pIzh14-11) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gattctctaaaagaacaaattaaagaagata	Protospacer
  **** ************.****** .* .

18. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to MN693193 (Marine virus AFVG_25M440, complete genome) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gtttctgttaaagaaaaaactaaaggtggta	Protospacer
 ******* ****** *********.*.. .

19. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NC_024215 (Lactococcus phage P078, complete genome) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
atggctgaaaaagaacaatctaaagatacca	Protospacer
 *  *** ********** *********  .

20. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NC_024208 (Lactococcus phage P118, complete genome) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
atggctgaaaaagaacaatctaaagatacca	Protospacer
 *  *** ********** *********  .

21. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NC_024214 (Lactococcus phage P162, complete genome) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
atggctgaaaaagaacaatctaaagatacca	Protospacer
 *  *** ********** *********  .

22. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NC_024203 (Lactococcus phage P092, complete genome) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
atggctgaaaaagaacaatctaaagatacca	Protospacer
 *  *** ********** *********  .

23. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to LR215720 (Staphylococcus phage Stab23 genome assembly, chromosome: I) position: , mismatch: 8, identity: 0.742

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
ggttctgtagcagaacaaactaaaggtgcaa	Protospacer
  *******. **************.*. *.

24. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024574 (Klebsiella pneumoniae strain INF274 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.75

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaaatatg	Protospacer
.******** ****.*********. . * **

25. spacer 16.1|5529989|34|NZ_AP018172|CRISPRCasFinder matches to NC_029065 (Pseudomonas phage VCM genome assembly VCM, chromosome : 1) position: , mismatch: 8, identity: 0.765

-tgctgtccaaactgggcaagctgttgctggggct	CRISPR spacer
atgacg-ccaaactggtcaagatgttgctggctcc	Protospacer
 ** .* ********* **** *********  *.

26. spacer 18.1|6744115|32|NZ_AP018172|CRISPRCasFinder matches to NC_020157 (Anabaena cylindrica PCC 7122 plasmid pANACY.02, complete sequence) position: , mismatch: 8, identity: 0.75

ttgtgatttaaggggttacgattttcaaaatc	CRISPR spacer
agttaattaaaggggtaacgattttcaaattt	Protospacer
   *.*** ******* ************ *.

27. spacer 18.1|6744115|32|NZ_AP018172|CRISPRCasFinder matches to GU943040 (Uncultured phage MedDCM-OCT-S09-C28 genomic sequence) position: , mismatch: 8, identity: 0.75

ttgtgatttaaggggttacgattttcaaaatc-----	CRISPR spacer
ttgtgatttaagggttgacgatt-----aacccgctg	Protospacer
************** * ******     **.*

28. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP009059 (Borreliella afzelii K78 plasmid lp54, complete sequence) position: , mismatch: 9, identity: 0.71

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
aacattagaaaaaaacaaactaaagataaat	Protospacer
  . .*. ****.*****************

29. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_LR214999 (Mycoplasma conjunctivae strain NCTC10147 plasmid 3) position: , mismatch: 9, identity: 0.71

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gaaggtgaaaaagaacaaaataaagataata	Protospacer
     ** *********** ********* .

30. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to LR214965 (Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 11) position: , mismatch: 9, identity: 0.71

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gaaggtgaaaaagaacaaaataaagataata	Protospacer
     ** *********** ********* .

31. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to NZ_CP046807 (Vibrio alginolyticus strain 2439-01 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.71

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gcgtgtgcataagaacaaactaaagatagta	Protospacer
 . * **.* ******************. .

32. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to MT840189 (Bacteriophage sp. Joined_contig_348 genomic sequence) position: , mismatch: 9, identity: 0.71

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
gcttctttaaaagaagaaactaaagggggtg	Protospacer
 .**** ******** *********. .. *

33. spacer 1.8|745437|31|NZ_AP018172|CRISPRCasFinder,CRT matches to KY794643 (Staphylococcus phage vB_Sau_S24, complete genome) position: , mismatch: 9, identity: 0.71

ttttctgtaaaagaacaaactaaagataaag	CRISPR spacer
ggttctgtagcagaacaaactaaaggtgcta	Protospacer
  *******. **************.*.  .

34. spacer 2.1|1028633|35|NZ_AP018172|PILER-CR,CRT matches to NZ_CP043555 (Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.743

--atttaacttttgatatttcaacagcgatcgctttg	CRISPR spacer
cgagttg--ttttgatatttcatcagcgaccgctaac	Protospacer
  * **.  ************* ******.****

35. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP043555 (Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.719

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
gttgttttgatatttcatcagcgaccgctaac	Protospacer
    ************* ******.****

36. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP042875 (Bacillus cereus strain 09 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
aaacttttgatattttaaaagcgagttctaac	Protospacer
 **************.** ***** . **

37. spacer 7.5|2730316|40|NZ_AP018172|CRT matches to NC_014533 (Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence) position: , mismatch: 9, identity: 0.775

ccaaaaggccctgcaataatataaagttctttgccttgac	CRISPR spacer
tgagaaccgccagcaataatataaagttcttttccttgag	Protospacer
. *.**   ** ******************** ******

38. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024195 (Klebsiella pneumoniae isolate KSB1_5D plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

39. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP023842 (Klebsiella pneumoniae strain 4/1-2 plasmid p4_1_2.3, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

40. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP029585 (Klebsiella pneumoniae strain DA33140 plasmid pDA33140-9, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

41. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024044 (Klebsiella pneumoniae strain QS17-0029 plasmid pMRSN479404_4.7, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

42. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024560 (Klebsiella pneumoniae strain INF164 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

43. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024532 (Klebsiella pneumoniae strain INF157 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

44. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024525 (Klebsiella pneumoniae strain INF158 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

45. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024553 (Klebsiella pneumoniae strain INF163 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

46. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024574 (Klebsiella pneumoniae strain INF274 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

47. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP021700 (Klebsiella pneumoniae strain AR_0158 plasmid tig00003569alt, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

48. spacer 2.9|1028636|32|NZ_AP018172|CRISPRCasFinder matches to NZ_CP024567 (Klebsiella pneumoniae strain INF278 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

taacttttgatatttcaacagcgatcgctttg	CRISPR spacer
caacttttgttattccaacagcgacaatatgt	Protospacer
.******** ****.*********. .. *

49. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448960 (Streptococcus phage Javan492, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

50. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448973 (Streptococcus phage Javan522, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

51. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to NC_004585 (Streptococcus prophage 315.2, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

52. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448966 (Streptococcus phage Javan508, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

53. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448772 (Streptococcus phage Javan483, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

54. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448778 (Streptococcus phage Javan493, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

55. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448962 (Streptococcus phage Javan496, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

56. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448793 (Streptococcus phage Javan523, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

57. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448954 (Streptococcus phage Javan476, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

58. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448975 (Streptococcus phage Javan526, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

59. spacer 2.12|1028861|34|NZ_AP018172|CRISPRCasFinder matches to MK448782 (Streptococcus phage Javan501, complete genome) position: , mismatch: 10, identity: 0.706

ataattcgttcagcaacaccaccaggtttagtaa	CRISPR spacer
ttaatacgttcagaaacaccaccagtcaaacttt	Protospacer
 **** ******* *********** .  * *

60. spacer 2.15|1029089|33|NZ_AP018172|CRISPRCasFinder matches to KT070867 (Bacillus phage PBC2, complete genome) position: , mismatch: 10, identity: 0.697

atcgcctaaaagttacctattttttcggtagaa	CRISPR spacer
tccgcctaaatgttacctattttttcttctttt	Protospacer
 .******** ***************  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3002322 : 3050808

Bacillus_phage(28.57%)

transposase,protease,tail,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096595234.1\|3002322_3003489_+\|transposase	transposase	A0A218MNH3	uncultured_virus	6.9e-59	35.9
WP_096588878.1\|3003533_3004073_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_096588880.1\|3005208_3005634_+	hypothetical protein	NA	NA	NA	NA
WP_096588882.1\|3005671_3006160_-	DUF1499 domain-containing protein	NA	NA	NA	NA
WP_096588884.1\|3006289_3007030_-	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_096588886.1\|3007231_3007597_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_096588888.1\|3007598_3012746_-	hypothetical protein	NA	NA	NA	NA
WP_096588890.1\|3012955_3014329_+	hypothetical protein	NA	NA	NA	NA
WP_096588892.1\|3014394_3015573_-	phosphoserine transaminase	NA	NA	NA	NA
WP_096588894.1\|3015709_3016177_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_096588896.1\|3016234_3016921_-	response regulator transcription factor	W8CYM9	Bacillus_phage	8.2e-28	33.6
WP_096595235.1\|3017022_3017787_-	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_096588898.1\|3017867_3018305_-	hypothetical protein	NA	NA	NA	NA
WP_096588900.1\|3018706_3019645_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096586464.1\|3019884_3020898_+\|transposase	transposase	NA	NA	NA	NA
WP_096588902.1\|3020855_3022895_-	hypothetical protein	NA	NA	NA	NA
WP_096588904.1\|3023162_3024545_+	3' terminal RNA ribose 2'-O-methyltransferase Hen1	NA	NA	NA	NA
WP_096588906.1\|3024557_3025007_+	ATP-binding protein	NA	NA	NA	NA
WP_096588907.1\|3024996_3025731_+	guanylyltransferase	B3FJH9	Pseudomonas_phage	2.5e-14	28.1
WP_096588909.1\|3025776_3028398_+	polynucleotide kinase-phosphatase	A0A1V0SJW2	Klosneuvirus	2.2e-20	20.7
WP_096588911.1\|3028949_3030272_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_096588913.1\|3030828_3031146_-	hypothetical protein	NA	NA	NA	NA
WP_096588915.1\|3031950_3032286_+	XisI protein	NA	NA	NA	NA
WP_096595236.1\|3033050_3034805_-	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_096588917.1\|3035068_3037036_-	ATP-binding protein	K9MCS8	Sulfolobus_virus	1.2e-07	32.9
WP_096588919.1\|3037032_3038322_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_096588921.1\|3038318_3040385_-	hypothetical protein	NA	NA	NA	NA
WP_096588923.1\|3040377_3041118_-\|plate	phage baseplate protein	NA	NA	NA	NA
WP_096588925.1\|3041131_3041671_-\|tail	phage tail protein	NA	NA	NA	NA
WP_096588927.1\|3041770_3043687_-\|tail	phage tail protein	J9PVC2	Bacillus_phage	2.1e-44	35.6
WP_096588929.1\|3044516_3044864_-	hypothetical protein	NA	NA	NA	NA
WP_096588931.1\|3045383_3045854_+	hypothetical protein	NA	NA	NA	NA
WP_096588933.1\|3046445_3048821_+	response regulator	A0A1V0SGX0	Hokovirus	2.1e-46	34.0
WP_096588935.1\|3048908_3050231_+	hybrid sensor histidine kinase/response regulator	NA	NA	NA	NA
WP_096588937.1\|3050304_3050808_-\|protease	protease inhibitor I42 family protein	NA	NA	NA	NA

DBSCAN-SWA_2

4109810 : 4183586

Bacillus_phage(22.22%)

transposase,protease,bacteriocin,integrase

attL 4100866:4100880|attR 4185787:4185801

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4100866:4100880	attL	NA	NA	NA	NA
WP_096595234.1\|4109810_4110977_-\|transposase	transposase	A0A218MNH3	uncultured_virus	6.9e-59	35.9
WP_096589822.1\|4111393_4111975_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_096589823.1\|4112530_4112911_-	hypothetical protein	NA	NA	NA	NA
WP_096589824.1\|4112932_4114474_-	resolvase	M1T2R9	Escherichia_phage	8.6e-17	39.4
WP_096589825.1\|4114789_4115656_-	hypothetical protein	NA	NA	NA	NA
WP_096589826.1\|4116432_4122807_+	AAA family ATPase	Q8QKV7	Ectocarpus_siliculosus_virus	2.6e-43	33.5
WP_096589827.1\|4122841_4124008_-	response regulator	W8CYM9	Bacillus_phage	3.7e-12	35.8
WP_096589828.1\|4124717_4125725_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_096589829.1\|4126062_4127163_+	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_096589830.1\|4127563_4127911_-	XisI protein	NA	NA	NA	NA
WP_096589831.1\|4128193_4128574_-\|protease	clan AA aspartic protease	NA	NA	NA	NA
WP_096595283.1\|4128570_4128843_-	hypothetical protein	NA	NA	NA	NA
WP_096589832.1\|4130424_4131462_-	fatty acid desaturase family protein	NA	NA	NA	NA
WP_096589833.1\|4131616_4132747_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_096595284.1\|4132753_4133875_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_096589834.1\|4134013_4135492_-	SET domain-containing protein-lysine N-methyltransferase	NA	NA	NA	NA
WP_096589835.1\|4135842_4138152_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_096595285.1\|4138214_4139384_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_096589836.1\|4140091_4142833_-\|bacteriocin	NHLP bacteriocin export ABC transporter permease/ATPase subunit	W8CYL7	Bacillus_phage	6.2e-26	25.1
WP_096589837.1\|4142822_4145039_-\|bacteriocin	NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit	F2Y165	Organic_Lake_phycodnavirus	8.0e-16	28.8
WP_096589838.1\|4145081_4146527_-\|bacteriocin	NHLP bacteriocin system secretion protein	NA	NA	NA	NA
WP_096589839.1\|4146523_4147552_-	cyclic nucleotide-binding domain-containing protein	NA	NA	NA	NA
WP_096589840.1\|4148454_4149981_-	response regulator	A0A1B1IWY2	uncultured_Mediterranean_phage	1.1e-13	28.3
WP_096589841.1\|4150057_4151083_-	chemotaxis response regulator protein-glutamate methylesterase	NA	NA	NA	NA
WP_096589842.1\|4151186_4154153_-	response regulator	Q56AR1	Bacillus_thuringiensis_phage	1.5e-09	23.5
WP_096589843.1\|4154212_4154950_-	purine-binding chemotaxis protein CheW	NA	NA	NA	NA
WP_096589844.1\|4154970_4156827_-	methyl-accepting chemotaxis protein	NA	NA	NA	NA
WP_096589845.1\|4157007_4158279_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_096589846.1\|4158283_4158742_-	chemotaxis protein CheW	NA	NA	NA	NA
WP_096589847.1\|4158765_4159743_-	hypothetical protein	NA	NA	NA	NA
WP_096589848.1\|4160020_4161430_+	MFS transporter	NA	NA	NA	NA
WP_096589849.1\|4161468_4162533_-	hypothetical protein	NA	NA	NA	NA
WP_096589850.1\|4162781_4163453_-	hypothetical protein	NA	NA	NA	NA
WP_096589851.1\|4163667_4163997_+	helix-turn-helix transcriptional regulator	A0A2K9V490	Faecalibacterium_phage	1.2e-05	35.2
WP_096589852.1\|4164368_4164686_-	ferredoxin	NA	NA	NA	NA
WP_096589853.1\|4164817_4166266_-	nitrogenase cofactor biosynthesis protein NifB	NA	NA	NA	NA
WP_096589854.1\|4167441_4168410_+	NAD(P)-dependent alcohol dehydrogenase	NA	NA	NA	NA
WP_096589855.1\|4168437_4169154_-	Uma2 family endonuclease	NA	NA	NA	NA
WP_096589856.1\|4169581_4170223_-	fimbrial protein	NA	NA	NA	NA
WP_096589857.1\|4170563_4171778_+	DUF4336 domain-containing protein	NA	NA	NA	NA
WP_096589858.1\|4171801_4172185_-	hypothetical protein	NA	NA	NA	NA
WP_096589859.1\|4172368_4173385_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_096589860.1\|4173534_4174326_-	DUF3891 family protein	NA	NA	NA	NA
WP_096589861.1\|4174374_4174608_-	hypothetical protein	NA	NA	NA	NA
WP_096589862.1\|4176436_4176664_-	hypothetical protein	NA	NA	NA	NA
WP_096589863.1\|4176695_4176881_-	hypothetical protein	NA	NA	NA	NA
WP_096589864.1\|4176883_4177195_-	hypothetical protein	NA	NA	NA	NA
WP_096589865.1\|4177243_4177447_-	hypothetical protein	NA	NA	NA	NA
WP_096589866.1\|4177540_4177741_-	hypothetical protein	NA	NA	NA	NA
WP_096589867.1\|4177727_4178273_-	hypothetical protein	NA	NA	NA	NA
WP_096589868.1\|4178254_4178527_-	hypothetical protein	NA	NA	NA	NA
WP_096589869.1\|4178526_4179033_-	hypothetical protein	NA	NA	NA	NA
WP_096589870.1\|4179038_4179284_-	hypothetical protein	NA	NA	NA	NA
WP_096589871.1\|4179273_4179723_-	hypothetical protein	NA	NA	NA	NA
WP_096589872.1\|4179763_4179967_-	hypothetical protein	NA	NA	NA	NA
WP_096589873.1\|4180240_4180669_+	hypothetical protein	NA	NA	NA	NA
WP_096589874.1\|4180814_4181792_+	hypothetical protein	NA	NA	NA	NA
WP_096589875.1\|4181880_4182627_+	hypothetical protein	NA	NA	NA	NA
WP_096589876.1\|4183004_4183586_-\|integrase	site-specific integrase	NA	NA	NA	NA
4185787:4185801	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage