CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	4 crisprs	cas2,cas1,csx18,csx1,cmr5gr11,cmr4gr7,cmr3gr5,cas10,WYL,Cas14u_CAS-V,PD-DExK	2	91	1	0
NZ_AP018204	Leptolyngbya boryana NIES-2135 plasmid plasmid1 DNA, complete genome	0 crisprs	RT,PD-DExK,csa3	0	0	0	0
NZ_AP018206	Leptolyngbya boryana NIES-2135 plasmid plasmid3 DNA, complete genome	0 crisprs	NA	0	0	0	0
NZ_AP018203	Leptolyngbya boryana NIES-2135 DNA, complete genome	15 crisprs	c2c5_V-U5,csa3,cas3,PD-DExK,cas4,DEDDh,DinG,Cas9_archaeal,Cas14b_CAS-V-F	1	5	1	0

1. NZ_AP018205

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP018205_1

• CRISPR_ID: NZ_AP018205_1
• CRISPR_location: 51310-51709
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 5 spacers
• Cas_protein_info: cas2,cas1,csx18,csx1,cmr5gr11,cmr4gr7,cmr3gr5,cas10

Consensus repeat of NZ_AP018205_1

Consensus_repeat	Method
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	CRT
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	PILER-CR
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CRISPRCasFinder

spacers of NZ_AP018205_1

>1.1|51346|42|NZ_AP018205|CRT
GATATCGCGGATCCACTGATGGATATCATTGAGGGCACTGCG
>1.2|51424|37|NZ_AP018205|CRT,CRISPRCasFinder
CATTACCGACCCTAATTCGGGAGAAGGAATCAACATC
>1.3|51497|36|NZ_AP018205|CRT,CRISPRCasFinder
TCGAACCTATAACCCTGCTAATGGAAAATGGCGTAT
>1.4|51569|35|NZ_AP018205|CRT,CRISPRCasFinder
AAGTGCATTTGGCTTGCCTATTAAAGGTGCAATGA
>1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder
TTGATGCAATCGCGACCGTGGCGCAACTGGAAG
>1.6|51347|42|NZ_AP018205|PILER-CR
GATATCGCGGATCCACTGATGGATATCATTGAGGGCACTGCG
>1.7|51425|37|NZ_AP018205|PILER-CR
CATTACCGACCCTAATTCGGGAGAAGGAATCAACATC
>1.8|51498|36|NZ_AP018205|PILER-CR
TCGAACCTATAACCCTGCTAATGGAAAATGGCGTAT
>1.9|51570|35|NZ_AP018205|PILER-CR
AAGTGCATTTGGCTTGCCTATTAAAGGTGCAATGA
>1.10|51641|33|NZ_AP018205|PILER-CR
TTGATGCAATCGCGACCGTGGCGCAACTGGAAG

CRISPR arrays and Neighbor proteins around NZ_AP018205_1

CRISPR arrays

The CRISPR arrays of NZ_AP018205_1

>merge|NZ_AP018205|1|51310-51709|CRT,PILER-CR,CRISPRCasFinder
TTTTCCACTCAATTGTGGTTCCCAACGAGTGAGAACGATATCGCGGATCCACTGATGGATATCATTGAGGGCACTGCGGTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACCATTACCGACCCTAATTCGGGAGAAGGAATCAACATCGTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACTCGAACCTATAACCCTGCTAATGGAAAATGGCGTATGTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACAAGTGCATTTGGCTTGCCTATTAAAGGTGCAATGAGTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACTTGATGCAATCGCGACCGTGGCGCAACTGGAAGGTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACG

>NZ_AP018205|1|1|51310-51708|CRT
TTTTCCACTCAATTGTGGTTCCCAACGAGTGAGAAC	GATATCGCGGATCCACTGATGGATATCATTGAGGGCACTGCG
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	CATTACCGACCCTAATTCGGGAGAAGGAATCAACATC
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	TCGAACCTATAACCCTGCTAATGGAAAATGGCGTAT
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	AAGTGCATTTGGCTTGCCTATTAAAGGTGCAATGA
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	TTGATGCAATCGCGACCGTGGCGCAACTGGAAG
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC

>NZ_AP018205|1|1|51311-51708|PILER-CR
TTTCCACTCAATTGTGGTTCCCAACGAGTGAGAACG	ATATCGCGGATCCACTGATGGATATCATTGAGGGCACTGCGG
TTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACC	ATTACCGACCCTAATTCGGGAGAAGGAATCAACATCG
TTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACT	CGAACCTATAACCCTGCTAATGGAAAATGGCGTATG
TTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACA	AGTGCATTTGGCTTGCCTATTAAAGGTGCAATGAG
TTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACT	TGATGCAATCGCGACCGTGGCGCAACTGGAAGG
TTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC

>NZ_AP018205|1|1|51388-51709|CRISPRCasFinder
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	CATTACCGACCCTAATTCGGGAGAAGGAATCAACATC
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	TCGAACCTATAACCCTGCTAATGGAAAATGGCGTAT
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	AAGTGCATTTGGCTTGCCTATTAAAGGTGCAATGA
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAAC	TTGATGCAATCGCGACCGTGGCGCAACTGGAAG
GTTTCCATTCAATTGTGGTTCCCAACGAGTGAGAACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl|CDD|187810
NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	unknown
NZ_AP018205.1|WP_017291543.1|49804_50110_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291540.1|47541_48207_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_071596251.1|42530_43271_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|136670
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NZ_AP018205.1|WP_086371089.1|59020_59212_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NZ_AP018205.1|WP_017291539.1|46554_47403_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_026149057.1|50261_50882_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291534.1|40174_41071_+|lytic-enzyme	unknown	unknown	gnl|CDD|225720
NZ_AP018205.1|WP_017291535.1|41402_42245_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|224255
NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein	unknown	unknown	gnl|CDD|187792
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	gnl|CDD|226481
NZ_AP018205.1|WP_017291542.1|49101_49638_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein	unknown	unknown	gnl|CDD|369567
NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|370625
NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein	unknown	unknown	gnl|CDD|178867

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	4.1e-29	95.1	1.6
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	cas10	cd09679_cas10_CAS-III	7.1e-21	69.2	0.0
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	6.3e-89	292.8	0.1
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	5.9e-27	89.7	0.0
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.4e-30	100.1	0.7
NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	7.3e-99	326.6	6.7
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	3.1e-14	47.8	0.3
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	4.9e-66	215.1	4.5

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	gnl|CDD|370625	pfam09700, Cas_Cmr3, CRISPR-associated protein (Cas_Cmr3). CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	1.11684e-08
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.05506e-24
NZ_AP018205.1|WP_017291534.1|40174_41071_+|lytic-enzyme	gnl|CDD|225720	COG3179, COG3179, Predicted chitinase [General function prediction only].	1.20658e-53
NZ_AP018205.1|WP_071596251.1|42530_43271_-|AAA-family-ATPase	gnl|CDD|136670	PRK08181, PRK08181, transposase; Validated.	8.57628e-86
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	8.84738e-107
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.86841e-31
NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein	gnl|CDD|369567	pfam07878, RHH_5, CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5. This family contains bacterial proteins that form a ribbon-helix-helix fold. This fold occurs in many examples of bacterial antitoxins.	5.91815e-09
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	gnl|CDD|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.40997e-18
NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein	gnl|CDD|178867	PRK00106, PRK00106, ribonuclease Y.	0.000748537
NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein	gnl|CDD|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	0.000752216
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	gnl|CDD|226481	COG3972, COG3972, Superfamily I DNA and RNA helicases [General function prediction only].	0.000941883

Protein sequences

>NZ_AP018205.1|WP_026149057.1|50261_50882_+|hypothetical-protein
MATLGITKAITNLSEAHSRLGVSPSLDALTFFTEWKGTLPALTDTERARLDHLKQRYLYYADSGAITEGTVNLILLSPLLETLNFIDPPYQVRSEKYVRFEIEDGDTQLDGLIDALILQDRLWLILIESKRYGFSVRQALPQTLAYMVSAPTSPVFALITTGEDYLFVKFDRDSSRYALSDKLTLSTVEGNELHVVAQILKRLINS
>NZ_AP018205.1|WP_017291543.1|49804_50110_+|hypothetical-protein
MSSDSGSIEGNKTPRIDDFGVTVEEYLEGLAKGIDILEVRSLERWGIPSELVMELIEINKRVSNGTAKPEEVVRGLQIMSPPIRRQRINEQDAELIESDSP
>NZ_AP018205.1|WP_017291542.1|49101_49638_+|hypothetical-protein
MIEGRIMDEEMLRQQYEQTGNLLDILKNPAVMEEIIRLESEYGEIGAGFPAYSKNPQPVTPNQANAVMRKVRLQSMVLIDLAELIQSVNLGVGTEAAITEGRRRIREHLAHLTDEQQAYFDALVDEDQLQLLDKPLRARLKSVVHLLLSDSDWNAIGQAATNALQNQWNEFIRNSKTA
>NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein
MSKRVFLTLPDGIADDLERWAASEKNKAATLAGFLVEEAVRRAKEQGKIPPDDGSFPHYDTLAELVRHNRNKLAESEKFSSARLKALSSGDKPTEVEILRLALILGRTEEYVLSLKTNPDVSEGSTN
>NZ_AP018205.1|WP_017291540.1|47541_48207_-|hypothetical-protein
MITTKAFKEQHDLSDSAFKRLVRKAKRQYPGGEFTRRINSTQWEVLHPAILESLISTTVAEPEFTDSTMTANKSASHLLQPLNLVPLHSLVPSHSQTVEVIPTSKVSTIADLNGQRDRLMQGQSEIEMALEVVQQTRQLVGYVLSVQRSQTTVDTQQVTQLEDAAFELQVHADCLRREDRRTSIEQGYRDQRRSEAQTQVVQMRDFFARRTEATASSEVQP
>NZ_AP018205.1|WP_017291539.1|46554_47403_-|hypothetical-protein
MLNRNQALQQNHPFYSHEVKSMPIRGKSKTAQDPNSALKSKSKKAKAETPSATEPTKTPKPTTAPTGILPTIALPLPNIPFRTTPPMTLSGGSSTAIHRKDLTQVNHGLDIPEFQPNQWMAKDLFTNSSPLPETSQAEADQAVLSIARKRQTLRIVRENIGLNRDIVGAATEHQQLLGAVIQYSTELVNNQTKFVKYTDAGVKQQIAAVKLSQSQEQFTQETIALDGLRQMTPLIQEEWNERLELRRAKINGLREQTLNANARLASKRQELEAMFNVEFQTI
>NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein
MSFLGGIVSFILFLAAIAQQSRIAQSLSLLGLATSTGGIVACALSDRTNQTREEVEALTQRLSDRDLTLAAKDDRIVNLTAELNRVMAFVDHLKSAPISVDRTSHIVAQYQEKLNTLQARYRAEVERVKTEARSQHQTELDRLRSEMVAADTRIHEFEQRFLDRAQETLSEALTSFHDRISDLVMDNLRKLSHLEPETRDATFAERLQQLSEEVTDLHQTYVAQILNLSHFLDAENILDCSDEALSILYHLMDDYTSIKVKVINALKAKTIRELQTTIQAYQAADLVPKAQLEQLVKNLKLRLQEYELDAVQHQESVVAIANDYEAQTLEDDRIVRGYIDQLAKLEHDNHQLKEQVASLSALKKFDPGAWGWGADIGNQVIDYLMSENIPCDALPLDFSPTDSHLTIALNCRTEAGLRMLAKDGKEFEKGMAAAKGWSHVSLTLTGRVVKVTVQYANRAIAKTKPEAVLDRPISDWDLYLAAEYHWFIAAAC
>NZ_AP018205.1|WP_071596251.1|42530_43271_-|AAA-family-ATPase
MLHHWETLEQQAMQEGWSYAQFLLVLCESEVQHRWSNRIQRALREAQLPSGKTVSNFDFSHCPSFNPAPLMQMADDPTWLGRAENLLLFGASGVGKSHLASAVSRRMVEFGKRVRFFSALALVQQLQQAKLQLQLQAMLKKLDRFDLLVLDDLGYVKKTEAETSVLFELIAHRYERKSLLITANQPFSQWDAIFTDSMMTVAAVDRLVHHALIVEIQTESYRKQSAVSRSEASKTAKKETVQPKRS
>NZ_AP018205.1|WP_017291535.1|41402_42245_-|hypothetical-protein
MEFHAITLKTDGNRDAEKARRFVAPVFKSSSKDYFEAQAGVLEEIESRKQILAVNPNHRYPRSIHQWDEYGEHYRIGGMREVTKMVLISSLQVGAGLSSENGKGIQVTFIAQNPYVSQLGLFRPDLANCCLIIVGEKNIRLFLNSDEDNHGLDKEDLERLKKELSLFKEASRKAVEKAQSEAQKNGADPRIAIAKCPERYYSLIVPSKGGLKPIILYNPAPGQFTNPLTQSSVSQNEPEVACEHDYKIVRSRKSKDGKTRQRDLECRKCGEKTKTAEPSQ
>NZ_AP018205.1|WP_017291534.1|40174_41071_+|lytic-enzyme
MSGIIEDNLNSVGSVAAWQNILNGCGYMPILKITGKMDEATISTTKRFQTDLGLAQTGTVTLETWRAGLRHSKLPGWSNITPPIQQVVIVSVDQILALAPGAKSSYVEAFKNGQAVFDRYDISKSSIRVAHFVAQIMHECGALTIQFENLNYSASRLPEVWPRVFQPTGPLDPSEYARNPEKLANEVYGKRMGNDNPGDGFRYRGRGLLQLTGKESYAEATQILRRTNPLAPDFVAQPDEVIDAAWCLEIAAAEWASKGCNALADKDDIKAITRRINGGQIGISDRIEWVKKTKLVWP
>NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2
MLIYVVTYDIPSDKRRKKIADLLEGYGQRVQYSVFECALSAVKFKELRKRLQQRIKIEEDSVRMYPISQQMLQQVEVWGGVEIVEPPGSTIV
>NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1
MKTLYVSHQGCYLSLRQESVLIKRGETILDQVQLPLLEQILIFGQSQVTTQVIRACLQRNIAIAYLSRMGKCYGRVLSITQGYRQLSRYQQLLSPELQLQTARIIVQAKLKNSRVILMRQQRRRASEQTALAIESLAYLVQQAGEAVSIARLMGLEGAGAASYFSAFGECLSGAGFVFLARSRRPPGNPVNAMLSFGYQVLWNHLLTLIELQGLDPYWGCLHQGHDRHAALASDLIEEFRSSIVDSLVLYLVNRGLVSADDDFEYHDGGCYLNQSGRRKFLQAFVQRMEESVEEQPRWNLLSQQVRAYKQFVYDPSCLYSPYLIR
>NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein
MYLSNRALQVRNASIAGISGALTLVILLIAPLGLAAVIINTLLVTIATFATGTVVDRVVISMQRDRNLPPTADLRRRESSNVDRYR
>NZ_AP018205.1|WP_086371089.1|59020_59212_-|hypothetical-protein
MGISFEMEGVRGWGDLAERVIVSLGASMPYGIRVLPHCLGLKLMKLFVFGLSLANRCWTLSGD
>NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein
MKIWLVTIGSSDVQLRTNDDWGDWYRVIRKDCHNLPFEPAQVIRDSAEPYRIAPRVLGIAYQAYPDEIWNALEFPLLKEFSIKLKDEAIDQIILLTTDQSYIFDENQRDDYKCPYWQDTSELQPILERYFQQHFPAVEVVLKVLAPQKGEFGLDDWNFVLDLVRSTLKELSGEPTAVYISHQAGTPAISSAVQFCSLARFRANVEFVVSNEYCPEQTRMISRSTYLRGLQTQEAKALLERYDYSGVKALLAPYLQAEVANLLEAAIQWNYAKFDRFAEHLQQAADIELAEFAKSRTTLENWWWTAYESAYLGFVRLKQGNTVEAMFHSFRSVEGLLRQWSNVLYGDEIKQTKHPRSEENQRWDRNLNAYGEDLYWFLTVKKSVDVTKNLKQNTTPDIFIFGNLVFKKRNDLFHQLKGLEGQEKVFENWQSPNEPKWKQDPEGHWKLRVLKCLNFICGENFSSLEEASLLVKVHQKIERAISQL
>NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein
MPDSDYVPLMFQAQVQGRSLIHQVKDLKKEAERLAVRKETLRQQAYDWAEQWQESCDVDTVPNFGNDVRKSKEYIFTWRMVTNSGQDEGVIRPVIGERGWAYFPGSSMKGAFLRACRQLHPDRVNRYCGGSAQEGEVHPGILRFHGGYPKDGAWLKNSMVDIVHPQANWQVSGSKLSHETPKVLISLHQPTFVFGISSTEPVLESEWTEIWKIWEKALERGIGSRVSAGYGQVKTHGESKLISVGLSGQGIASRRLDLEGEFRPNGFKAALRGHTHRLFHGITDHKTVNHLIKQLWGGIGKGESATVGLLGVAFSAPELELDEWVAAGNPNNHVPVYETGDAILNVLVMKDGLRQEQRDELKNFVIRLVKFSMLLGGFGRSWRRSDHRLFLPRYKRQMIGCHWTFTKPSRKLYIPVSDDKLVSITRFLDLFYQKAQEFSWLNEIENRKTPDHSCREAWCKDNVQVWGRIADGEEDSIAIKWLHQDYKRGSSIKQSELTGSMKQIGRLWHRMYPRYLKRGEEWIETQEYIELLTIFPNRSGDKDEIQKTANFLKFLQDFTDFKQLW
>NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein
MSWKMYEIDRCAHDLVLKFRDKKDVLNESHKMRVTTAYGLERFWGEHLRLQRENQDKADYWKETWDELCRILRQAGIQIPNDPVSTENSAAIKTMTDKLWNFDQEQRKIALAILIELCDSLIWWTQRYKKPKQGVGGKTDAR
>NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYKKTYGIIETLAPLHVGATAGEESGNLNLIFRDQFTQTGILPGSSIRGRFRSEMRRDQSGDANYWYGSPAETGESDTTSESIVKFEYASLLWLPVFCPGQPIVWVSSPKLLKRYQRIAGNSVDGLKSIKTSAIDRLKYVGSSTLKTLNVEGKKKLFFNFGFLTLDKTEDLSIWFPNGEQLPAVVVGDDEIGMIHDMALYRQSRVRLMDREKRVDKGGFFNTEALPEGTIMVFPIAIRNTATTPWQPFGDGIETSEIYLGGLESIGFGNCQITLKNLNTVAHSQEVAA
>NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein
MFQHLITIAPLGLMYGSAGAFLSPENLVGRSGAKFPPDASTVAGLFFSANHSLKGAIAPHDTLKHNLHIAGPFWAKRDQPEVFYVPVPRHRIIAEEQEDEWRLEKHRWQRDLQKEDIEAFYTWQSIDAWNRETRQIRTNREAAQAPWKYVSFLHPQMKAEERHVLDQDGLFLENAVQMDEDYCLVYLSTHAFPEGWYRFGGEGHMVEINSQSLSPSSIIHQLLQTPIDRACALITPGVWGSHNLSYRYPRHPEFPREGMQMLTDKATPCRYRLGNRTTERGRLSRGRYAVPVGTVYVFKHPLNRCWWDFPDDWFPDKGLMKKLGSGLCLPIQIQGVA
>NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein
MPIYTAISFAPVQGFIEKSRKLRDLFGASLILSYLSQSLANAADQTPELKVISPALIHVQEGMPNRILIQGLFPRNEVEKVLIQAWDKVLQPCREWIETNVPVHDLYHWDAEWLRWKQYTWEIFWGKGDDPSAAMNDLERRKLKRDWVGINWTGESSSLTGTDAIAWHRLGEVRDPKHLLSEAEKRELKEFYRQLAWVLDDPHQRCGKIVDAGVEPEGKFIAANERLSLPELIKRLVTLPKLAKKIGLEDLAEGFKDIYREPGYWTGWFMGDGDQIGNKLKDIVQRYGDEKLEVFSHKMRSWGQTFQDDSTQFPQGKGRVIYAGGDDFLGVIYSEQNQSGEPAPEQVKPIDALNWLMQLPDQWQTLKTELWHDLEIEHTYSVGFVWAGHSVPQRDILQHCREAEKQAKSLGRDRVTIRIVFNNGQFIQWTCPWSYLSILTKYQDREGRTWGDAKLNWTHLYSDWEQLKARHAIRLTETDQYHADSYLALQLFNFYFDDAGKAIQKNPQDKRWKYLVGSNSELAIVQWIDSLIQIGWQLCSNI

Crispr_ID: NZ_AP018205_2

• CRISPR_ID: NZ_AP018205_2
• CRISPR_location: 52114-53637
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 19 spacers
• Cas_protein_info: cas2,cas1,csx18,csx1,cmr5gr11,cmr4gr7,cmr3gr5,cas10

Consensus repeat of NZ_AP018205_2

Consensus_repeat	Method
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CRISPRCasFinder
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CRT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	PILER-CR

spacers of NZ_AP018205_2

>2.1|52150|46|NZ_AP018205|CRISPRCasFinder,CRT
CTGAGTCAAGAGGCTAGGAAAGTTGCTTCAAGAATTATGGTCGAGT
>2.2|52232|39|NZ_AP018205|CRISPRCasFinder,CRT
AATTTCGTAATCATCCGACGATTCGACGCACGATCGATG
>2.3|52307|41|NZ_AP018205|CRISPRCasFinder,CRT
AACAGAAATCTTGGCGGACTTGATGACTTGTTTGGGTAGGG
>2.4|52384|52|NZ_AP018205|CRISPRCasFinder,CRT
TTGCAATTGGACAGCTCATCAAAAATCTCAGTTTATTCAGCAAATTATTCAA
>2.5|52472|39|NZ_AP018205|CRISPRCasFinder,CRT
TTGAGCAACGATTAGAAGCCACCCGGATGTTGATTGAAG
>2.6|52547|43|NZ_AP018205|CRISPRCasFinder,CRT
CGGAAGACATCCAACATCTTACGCTCATGCGTAACCAGTTAAA
>2.7|52626|46|NZ_AP018205|CRISPRCasFinder,CRT
CCACTGCGATCACTACGGGATTGTCCCCGGAGGTAAGTGTCTGTGC
>2.8|52708|40|NZ_AP018205|CRISPRCasFinder,CRT
GTACCACAAGAAAAACGCTAGAGATCCATGTATACAGCAA
>2.9|52784|46|NZ_AP018205|CRISPRCasFinder,CRT
TCAGAAATCGAAGCTTTGATTGGCTCCTCTCGTAAAGAGGTGGAAA
>2.10|52866|41|NZ_AP018205|CRISPRCasFinder,CRT
GCGTATTATGAGGGATTGACAGAGAAGAGGGGCGATCGTGT
>2.11|52943|49|NZ_AP018205|CRISPRCasFinder,CRT
CTCACATTTTGAGCAGCTTCCTTATATTTCTCAACAGGAATACAAGTGA
>2.12|53028|41|NZ_AP018205|CRISPRCasFinder,CRT
CACCGTATGTTGCTGCTGGCGCAGCTTACCCCCCAAATTAT
>2.13|53105|40|NZ_AP018205|CRISPRCasFinder,CRT
GTGGAGAGAATATCTTGGTGCGTATGGTATCAACCCTGAC
>2.14|53181|41|NZ_AP018205|CRISPRCasFinder,CRT
AGCCAGTGAAATTGGAGTTGTTTGGCTGGGATTAATCCCGG
>2.15|53258|41|NZ_AP018205|CRISPRCasFinder,CRT
TTAGGTAATAAATATCAGCTTTCTTTTGTGGGTGATCTTAT
>2.16|53335|38|NZ_AP018205|CRISPRCasFinder,CRT
AACCCTTCGAACCTGTTCCTTCTACTTTAGAAGAAATG
>2.17|53409|41|NZ_AP018205|CRISPRCasFinder,CRT
AAGCTAATAAGCATTATCACGATAATGCAAATCCAAACCTT
>2.18|53486|38|NZ_AP018205|CRISPRCasFinder,CRT
ACTGTAGAAGGAATTCAATGGGCTGGTAAAGTATGCTC
>2.19|53560|42|NZ_AP018205|CRISPRCasFinder,CRT
GAAGCTGAGCTTAATGCTTTCTTTACTAAAGAAGCGACTCTT
>2.20|52152|46|NZ_AP018205|PILER-CR
CTGAGTCAAGAGGCTAGGAAAGTTGCTTCAAGAATTATGGTCGAGT
>2.21|52234|39|NZ_AP018205|PILER-CR
AATTTCGTAATCATCCGACGATTCGACGCACGATCGATG
>2.22|52309|41|NZ_AP018205|PILER-CR
AACAGAAATCTTGGCGGACTTGATGACTTGTTTGGGTAGGG
>2.23|52386|52|NZ_AP018205|PILER-CR
TTGCAATTGGACAGCTCATCAAAAATCTCAGTTTATTCAGCAAATTATTCAA
>2.24|52474|39|NZ_AP018205|PILER-CR
TTGAGCAACGATTAGAAGCCACCCGGATGTTGATTGAAG
>2.25|52549|43|NZ_AP018205|PILER-CR
CGGAAGACATCCAACATCTTACGCTCATGCGTAACCAGTTAAA
>2.26|52628|46|NZ_AP018205|PILER-CR
CCACTGCGATCACTACGGGATTGTCCCCGGAGGTAAGTGTCTGTGC
>2.27|52710|40|NZ_AP018205|PILER-CR
GTACCACAAGAAAAACGCTAGAGATCCATGTATACAGCAA
>2.28|52786|46|NZ_AP018205|PILER-CR
TCAGAAATCGAAGCTTTGATTGGCTCCTCTCGTAAAGAGGTGGAAA
>2.29|52868|41|NZ_AP018205|PILER-CR
GCGTATTATGAGGGATTGACAGAGAAGAGGGGCGATCGTGT
>2.30|52945|49|NZ_AP018205|PILER-CR
CTCACATTTTGAGCAGCTTCCTTATATTTCTCAACAGGAATACAAGTGA
>2.31|53030|41|NZ_AP018205|PILER-CR
CACCGTATGTTGCTGCTGGCGCAGCTTACCCCCCAAATTAT
>2.32|53107|40|NZ_AP018205|PILER-CR
GTGGAGAGAATATCTTGGTGCGTATGGTATCAACCCTGAC
>2.33|53183|41|NZ_AP018205|PILER-CR
AGCCAGTGAAATTGGAGTTGTTTGGCTGGGATTAATCCCGG
>2.34|53260|41|NZ_AP018205|PILER-CR
TTAGGTAATAAATATCAGCTTTCTTTTGTGGGTGATCTTAT
>2.35|53337|38|NZ_AP018205|PILER-CR
AACCCTTCGAACCTGTTCCTTCTACTTTAGAAGAAATG
>2.36|53411|41|NZ_AP018205|PILER-CR
AAGCTAATAAGCATTATCACGATAATGCAAATCCAAACCTT
>2.37|53488|38|NZ_AP018205|PILER-CR
ACTGTAGAAGGAATTCAATGGGCTGGTAAAGTATGCTC
>2.38|53562|42|NZ_AP018205|PILER-CR
GAAGCTGAGCTTAATGCTTTCTTTACTAAAGAAGCGACTCTT

CRISPR arrays and Neighbor proteins around NZ_AP018205_2

CRISPR arrays

The CRISPR arrays of NZ_AP018205_2

>merge|NZ_AP018205|2|52114-53637|CRISPRCasFinder,CRT,PILER-CR
GCTTTCATTCAATTGTTTGCCCCCATCAATGGAGACCTGAGTCAAGAGGCTAGGAAAGTTGCTTCAAGAATTATGGTCGAGTGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACAATTTCGTAATCATCCGACGATTCGACGCACGATCGATGGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACAACAGAAATCTTGGCGGACTTGATGACTTGTTTGGGTAGGGGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACTTGCAATTGGACAGCTCATCAAAAATCTCAGTTTATTCAGCAAATTATTCAAGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACTTGAGCAACGATTAGAAGCCACCCGGATGTTGATTGAAGGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACCGGAAGACATCCAACATCTTACGCTCATGCGTAACCAGTTAAAGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACCCACTGCGATCACTACGGGATTGTCCCCGGAGGTAAGTGTCTGTGCGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACGTACCACAAGAAAAACGCTAGAGATCCATGTATACAGCAAGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACTCAGAAATCGAAGCTTTGATTGGCTCCTCTCGTAAAGAGGTGGAAAGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACGCGTATTATGAGGGATTGACAGAGAAGAGGGGCGATCGTGTGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACCTCACATTTTGAGCAGCTTCCTTATATTTCTCAACAGGAATACAAGTGAGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACCACCGTATGTTGCTGCTGGCGCAGCTTACCCCCCAAATTATGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACGTGGAGAGAATATCTTGGTGCGTATGGTATCAACCCTGACGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACAGCCAGTGAAATTGGAGTTGTTTGGCTGGGATTAATCCCGGGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACTTAGGTAATAAATATCAGCTTTCTTTTGTGGGTGATCTTATGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACAACCCTTCGAACCTGTTCCTTCTACTTTAGAAGAAATGGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACAAGCTAATAAGCATTATCACGATAATGCAAATCCAAACCTTGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACACTGTAGAAGGAATTCAATGGGCTGGTAAAGTATGCTCGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGACGAAGCTGAGCTTAATGCTTTCTTTACTAAAGAAGCGACTCTTGTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC

>NZ_AP018205|2|2|52114-53637|CRISPRCasFinder
GCTTTCATTCAATTGTTTGCCCCCATCAATGGAGAC	CTGAGTCAAGAGGCTAGGAAAGTTGCTTCAAGAATTATGGTCGAGT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AATTTCGTAATCATCCGACGATTCGACGCACGATCGATG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AACAGAAATCTTGGCGGACTTGATGACTTGTTTGGGTAGGG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TTGCAATTGGACAGCTCATCAAAAATCTCAGTTTATTCAGCAAATTATTCAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TTGAGCAACGATTAGAAGCCACCCGGATGTTGATTGAAG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CGGAAGACATCCAACATCTTACGCTCATGCGTAACCAGTTAAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CCACTGCGATCACTACGGGATTGTCCCCGGAGGTAAGTGTCTGTGC
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GTACCACAAGAAAAACGCTAGAGATCCATGTATACAGCAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TCAGAAATCGAAGCTTTGATTGGCTCCTCTCGTAAAGAGGTGGAAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GCGTATTATGAGGGATTGACAGAGAAGAGGGGCGATCGTGT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CTCACATTTTGAGCAGCTTCCTTATATTTCTCAACAGGAATACAAGTGA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CACCGTATGTTGCTGCTGGCGCAGCTTACCCCCCAAATTAT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GTGGAGAGAATATCTTGGTGCGTATGGTATCAACCCTGAC
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AGCCAGTGAAATTGGAGTTGTTTGGCTGGGATTAATCCCGG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TTAGGTAATAAATATCAGCTTTCTTTTGTGGGTGATCTTAT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AACCCTTCGAACCTGTTCCTTCTACTTTAGAAGAAATG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AAGCTAATAAGCATTATCACGATAATGCAAATCCAAACCTT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	ACTGTAGAAGGAATTCAATGGGCTGGTAAAGTATGCTC
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GAAGCTGAGCTTAATGCTTTCTTTACTAAAGAAGCGACTCTT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC

>NZ_AP018205|2|2|52114-53637|CRT
GCTTTCATTCAATTGTTTGCCCCCATCAATGGAGAC	CTGAGTCAAGAGGCTAGGAAAGTTGCTTCAAGAATTATGGTCGAGT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AATTTCGTAATCATCCGACGATTCGACGCACGATCGATG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AACAGAAATCTTGGCGGACTTGATGACTTGTTTGGGTAGGG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TTGCAATTGGACAGCTCATCAAAAATCTCAGTTTATTCAGCAAATTATTCAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TTGAGCAACGATTAGAAGCCACCCGGATGTTGATTGAAG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CGGAAGACATCCAACATCTTACGCTCATGCGTAACCAGTTAAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CCACTGCGATCACTACGGGATTGTCCCCGGAGGTAAGTGTCTGTGC
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GTACCACAAGAAAAACGCTAGAGATCCATGTATACAGCAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TCAGAAATCGAAGCTTTGATTGGCTCCTCTCGTAAAGAGGTGGAAA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GCGTATTATGAGGGATTGACAGAGAAGAGGGGCGATCGTGT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CTCACATTTTGAGCAGCTTCCTTATATTTCTCAACAGGAATACAAGTGA
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	CACCGTATGTTGCTGCTGGCGCAGCTTACCCCCCAAATTAT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GTGGAGAGAATATCTTGGTGCGTATGGTATCAACCCTGAC
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AGCCAGTGAAATTGGAGTTGTTTGGCTGGGATTAATCCCGG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	TTAGGTAATAAATATCAGCTTTCTTTTGTGGGTGATCTTAT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AACCCTTCGAACCTGTTCCTTCTACTTTAGAAGAAATG
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	AAGCTAATAAGCATTATCACGATAATGCAAATCCAAACCTT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	ACTGTAGAAGGAATTCAATGGGCTGGTAAAGTATGCTC
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC	GAAGCTGAGCTTAATGCTTTCTTTACTAAAGAAGCGACTCTT
GTTTCCATTCAATTGTTTGCCCCCATCAATGGAGAC

>NZ_AP018205|2|2|52116-53637|PILER-CR
TTTCATTCAATTGTTTGCCCCCATCAATGGAGACCT	GAGTCAAGAGGCTAGGAAAGTTGCTTCAAGAATTATGGTCGAGTGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACAA	TTTCGTAATCATCCGACGATTCGACGCACGATCGATGGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACAA	CAGAAATCTTGGCGGACTTGATGACTTGTTTGGGTAGGGGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACTT	GCAATTGGACAGCTCATCAAAAATCTCAGTTTATTCAGCAAATTATTCAAGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACTT	GAGCAACGATTAGAAGCCACCCGGATGTTGATTGAAGGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACCG	GAAGACATCCAACATCTTACGCTCATGCGTAACCAGTTAAAGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACCC	ACTGCGATCACTACGGGATTGTCCCCGGAGGTAAGTGTCTGTGCGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACGT	ACCACAAGAAAAACGCTAGAGATCCATGTATACAGCAAGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACTC	AGAAATCGAAGCTTTGATTGGCTCCTCTCGTAAAGAGGTGGAAAGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACGC	GTATTATGAGGGATTGACAGAGAAGAGGGGCGATCGTGTGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACCT	CACATTTTGAGCAGCTTCCTTATATTTCTCAACAGGAATACAAGTGAGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACCA	CCGTATGTTGCTGCTGGCGCAGCTTACCCCCCAAATTATGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACGT	GGAGAGAATATCTTGGTGCGTATGGTATCAACCCTGACGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACAG	CCAGTGAAATTGGAGTTGTTTGGCTGGGATTAATCCCGGGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACTT	AGGTAATAAATATCAGCTTTCTTTTGTGGGTGATCTTATGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACAA	CCCTTCGAACCTGTTCCTTCTACTTTAGAAGAAATGGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACAA	GCTAATAAGCATTATCACGATAATGCAAATCCAAACCTTGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACAC	TGTAGAAGGAATTCAATGGGCTGGTAAAGTATGCTCGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGACGA	AGCTGAGCTTAATGCTTTCTTTACTAAAGAAGCGACTCTTGT
TTCCATTCAATTGTTTGCCCCCATCAATGGAGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl|CDD|187810
NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	unknown
NZ_AP018205.1|WP_017291543.1|49804_50110_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291540.1|47541_48207_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_071596251.1|42530_43271_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|136670
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NZ_AP018205.1|WP_086371089.1|59020_59212_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NZ_AP018205.1|WP_017291539.1|46554_47403_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_026149057.1|50261_50882_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291534.1|40174_41071_+|lytic-enzyme	unknown	unknown	gnl|CDD|225720
NZ_AP018205.1|WP_017291535.1|41402_42245_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|224255
NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein	unknown	unknown	gnl|CDD|187792
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	gnl|CDD|226481
NZ_AP018205.1|WP_017291542.1|49101_49638_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein	unknown	unknown	gnl|CDD|369567
NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|370625
NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein	unknown	unknown	gnl|CDD|178867

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	4.1e-29	95.1	1.6
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	cas10	cd09679_cas10_CAS-III	7.1e-21	69.2	0.0
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	6.3e-89	292.8	0.1
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	5.9e-27	89.7	0.0
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.4e-30	100.1	0.7
NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	7.3e-99	326.6	6.7
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	3.1e-14	47.8	0.3
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	4.9e-66	215.1	4.5

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	gnl|CDD|370625	pfam09700, Cas_Cmr3, CRISPR-associated protein (Cas_Cmr3). CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	1.11684e-08
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.05506e-24
NZ_AP018205.1|WP_017291534.1|40174_41071_+|lytic-enzyme	gnl|CDD|225720	COG3179, COG3179, Predicted chitinase [General function prediction only].	1.20658e-53
NZ_AP018205.1|WP_071596251.1|42530_43271_-|AAA-family-ATPase	gnl|CDD|136670	PRK08181, PRK08181, transposase; Validated.	8.57628e-86
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	8.84738e-107
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.86841e-31
NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein	gnl|CDD|369567	pfam07878, RHH_5, CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5. This family contains bacterial proteins that form a ribbon-helix-helix fold. This fold occurs in many examples of bacterial antitoxins.	5.91815e-09
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	gnl|CDD|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.40997e-18
NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein	gnl|CDD|178867	PRK00106, PRK00106, ribonuclease Y.	0.000748537
NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein	gnl|CDD|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	0.000752216
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	gnl|CDD|226481	COG3972, COG3972, Superfamily I DNA and RNA helicases [General function prediction only].	0.000941883

Protein sequences

>NZ_AP018205.1|WP_026149057.1|50261_50882_+|hypothetical-protein
MATLGITKAITNLSEAHSRLGVSPSLDALTFFTEWKGTLPALTDTERARLDHLKQRYLYYADSGAITEGTVNLILLSPLLETLNFIDPPYQVRSEKYVRFEIEDGDTQLDGLIDALILQDRLWLILIESKRYGFSVRQALPQTLAYMVSAPTSPVFALITTGEDYLFVKFDRDSSRYALSDKLTLSTVEGNELHVVAQILKRLINS
>NZ_AP018205.1|WP_017291543.1|49804_50110_+|hypothetical-protein
MSSDSGSIEGNKTPRIDDFGVTVEEYLEGLAKGIDILEVRSLERWGIPSELVMELIEINKRVSNGTAKPEEVVRGLQIMSPPIRRQRINEQDAELIESDSP
>NZ_AP018205.1|WP_017291542.1|49101_49638_+|hypothetical-protein
MIEGRIMDEEMLRQQYEQTGNLLDILKNPAVMEEIIRLESEYGEIGAGFPAYSKNPQPVTPNQANAVMRKVRLQSMVLIDLAELIQSVNLGVGTEAAITEGRRRIREHLAHLTDEQQAYFDALVDEDQLQLLDKPLRARLKSVVHLLLSDSDWNAIGQAATNALQNQWNEFIRNSKTA
>NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein
MSKRVFLTLPDGIADDLERWAASEKNKAATLAGFLVEEAVRRAKEQGKIPPDDGSFPHYDTLAELVRHNRNKLAESEKFSSARLKALSSGDKPTEVEILRLALILGRTEEYVLSLKTNPDVSEGSTN
>NZ_AP018205.1|WP_017291540.1|47541_48207_-|hypothetical-protein
MITTKAFKEQHDLSDSAFKRLVRKAKRQYPGGEFTRRINSTQWEVLHPAILESLISTTVAEPEFTDSTMTANKSASHLLQPLNLVPLHSLVPSHSQTVEVIPTSKVSTIADLNGQRDRLMQGQSEIEMALEVVQQTRQLVGYVLSVQRSQTTVDTQQVTQLEDAAFELQVHADCLRREDRRTSIEQGYRDQRRSEAQTQVVQMRDFFARRTEATASSEVQP
>NZ_AP018205.1|WP_017291539.1|46554_47403_-|hypothetical-protein
MLNRNQALQQNHPFYSHEVKSMPIRGKSKTAQDPNSALKSKSKKAKAETPSATEPTKTPKPTTAPTGILPTIALPLPNIPFRTTPPMTLSGGSSTAIHRKDLTQVNHGLDIPEFQPNQWMAKDLFTNSSPLPETSQAEADQAVLSIARKRQTLRIVRENIGLNRDIVGAATEHQQLLGAVIQYSTELVNNQTKFVKYTDAGVKQQIAAVKLSQSQEQFTQETIALDGLRQMTPLIQEEWNERLELRRAKINGLREQTLNANARLASKRQELEAMFNVEFQTI
>NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein
MSFLGGIVSFILFLAAIAQQSRIAQSLSLLGLATSTGGIVACALSDRTNQTREEVEALTQRLSDRDLTLAAKDDRIVNLTAELNRVMAFVDHLKSAPISVDRTSHIVAQYQEKLNTLQARYRAEVERVKTEARSQHQTELDRLRSEMVAADTRIHEFEQRFLDRAQETLSEALTSFHDRISDLVMDNLRKLSHLEPETRDATFAERLQQLSEEVTDLHQTYVAQILNLSHFLDAENILDCSDEALSILYHLMDDYTSIKVKVINALKAKTIRELQTTIQAYQAADLVPKAQLEQLVKNLKLRLQEYELDAVQHQESVVAIANDYEAQTLEDDRIVRGYIDQLAKLEHDNHQLKEQVASLSALKKFDPGAWGWGADIGNQVIDYLMSENIPCDALPLDFSPTDSHLTIALNCRTEAGLRMLAKDGKEFEKGMAAAKGWSHVSLTLTGRVVKVTVQYANRAIAKTKPEAVLDRPISDWDLYLAAEYHWFIAAAC
>NZ_AP018205.1|WP_071596251.1|42530_43271_-|AAA-family-ATPase
MLHHWETLEQQAMQEGWSYAQFLLVLCESEVQHRWSNRIQRALREAQLPSGKTVSNFDFSHCPSFNPAPLMQMADDPTWLGRAENLLLFGASGVGKSHLASAVSRRMVEFGKRVRFFSALALVQQLQQAKLQLQLQAMLKKLDRFDLLVLDDLGYVKKTEAETSVLFELIAHRYERKSLLITANQPFSQWDAIFTDSMMTVAAVDRLVHHALIVEIQTESYRKQSAVSRSEASKTAKKETVQPKRS
>NZ_AP018205.1|WP_017291535.1|41402_42245_-|hypothetical-protein
MEFHAITLKTDGNRDAEKARRFVAPVFKSSSKDYFEAQAGVLEEIESRKQILAVNPNHRYPRSIHQWDEYGEHYRIGGMREVTKMVLISSLQVGAGLSSENGKGIQVTFIAQNPYVSQLGLFRPDLANCCLIIVGEKNIRLFLNSDEDNHGLDKEDLERLKKELSLFKEASRKAVEKAQSEAQKNGADPRIAIAKCPERYYSLIVPSKGGLKPIILYNPAPGQFTNPLTQSSVSQNEPEVACEHDYKIVRSRKSKDGKTRQRDLECRKCGEKTKTAEPSQ
>NZ_AP018205.1|WP_017291534.1|40174_41071_+|lytic-enzyme
MSGIIEDNLNSVGSVAAWQNILNGCGYMPILKITGKMDEATISTTKRFQTDLGLAQTGTVTLETWRAGLRHSKLPGWSNITPPIQQVVIVSVDQILALAPGAKSSYVEAFKNGQAVFDRYDISKSSIRVAHFVAQIMHECGALTIQFENLNYSASRLPEVWPRVFQPTGPLDPSEYARNPEKLANEVYGKRMGNDNPGDGFRYRGRGLLQLTGKESYAEATQILRRTNPLAPDFVAQPDEVIDAAWCLEIAAAEWASKGCNALADKDDIKAITRRINGGQIGISDRIEWVKKTKLVWP
>NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2
MLIYVVTYDIPSDKRRKKIADLLEGYGQRVQYSVFECALSAVKFKELRKRLQQRIKIEEDSVRMYPISQQMLQQVEVWGGVEIVEPPGSTIV
>NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1
MKTLYVSHQGCYLSLRQESVLIKRGETILDQVQLPLLEQILIFGQSQVTTQVIRACLQRNIAIAYLSRMGKCYGRVLSITQGYRQLSRYQQLLSPELQLQTARIIVQAKLKNSRVILMRQQRRRASEQTALAIESLAYLVQQAGEAVSIARLMGLEGAGAASYFSAFGECLSGAGFVFLARSRRPPGNPVNAMLSFGYQVLWNHLLTLIELQGLDPYWGCLHQGHDRHAALASDLIEEFRSSIVDSLVLYLVNRGLVSADDDFEYHDGGCYLNQSGRRKFLQAFVQRMEESVEEQPRWNLLSQQVRAYKQFVYDPSCLYSPYLIR
>NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein
MYLSNRALQVRNASIAGISGALTLVILLIAPLGLAAVIINTLLVTIATFATGTVVDRVVISMQRDRNLPPTADLRRRESSNVDRYR
>NZ_AP018205.1|WP_086371089.1|59020_59212_-|hypothetical-protein
MGISFEMEGVRGWGDLAERVIVSLGASMPYGIRVLPHCLGLKLMKLFVFGLSLANRCWTLSGD
>NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein
MKIWLVTIGSSDVQLRTNDDWGDWYRVIRKDCHNLPFEPAQVIRDSAEPYRIAPRVLGIAYQAYPDEIWNALEFPLLKEFSIKLKDEAIDQIILLTTDQSYIFDENQRDDYKCPYWQDTSELQPILERYFQQHFPAVEVVLKVLAPQKGEFGLDDWNFVLDLVRSTLKELSGEPTAVYISHQAGTPAISSAVQFCSLARFRANVEFVVSNEYCPEQTRMISRSTYLRGLQTQEAKALLERYDYSGVKALLAPYLQAEVANLLEAAIQWNYAKFDRFAEHLQQAADIELAEFAKSRTTLENWWWTAYESAYLGFVRLKQGNTVEAMFHSFRSVEGLLRQWSNVLYGDEIKQTKHPRSEENQRWDRNLNAYGEDLYWFLTVKKSVDVTKNLKQNTTPDIFIFGNLVFKKRNDLFHQLKGLEGQEKVFENWQSPNEPKWKQDPEGHWKLRVLKCLNFICGENFSSLEEASLLVKVHQKIERAISQL
>NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein
MPDSDYVPLMFQAQVQGRSLIHQVKDLKKEAERLAVRKETLRQQAYDWAEQWQESCDVDTVPNFGNDVRKSKEYIFTWRMVTNSGQDEGVIRPVIGERGWAYFPGSSMKGAFLRACRQLHPDRVNRYCGGSAQEGEVHPGILRFHGGYPKDGAWLKNSMVDIVHPQANWQVSGSKLSHETPKVLISLHQPTFVFGISSTEPVLESEWTEIWKIWEKALERGIGSRVSAGYGQVKTHGESKLISVGLSGQGIASRRLDLEGEFRPNGFKAALRGHTHRLFHGITDHKTVNHLIKQLWGGIGKGESATVGLLGVAFSAPELELDEWVAAGNPNNHVPVYETGDAILNVLVMKDGLRQEQRDELKNFVIRLVKFSMLLGGFGRSWRRSDHRLFLPRYKRQMIGCHWTFTKPSRKLYIPVSDDKLVSITRFLDLFYQKAQEFSWLNEIENRKTPDHSCREAWCKDNVQVWGRIADGEEDSIAIKWLHQDYKRGSSIKQSELTGSMKQIGRLWHRMYPRYLKRGEEWIETQEYIELLTIFPNRSGDKDEIQKTANFLKFLQDFTDFKQLW
>NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein
MSWKMYEIDRCAHDLVLKFRDKKDVLNESHKMRVTTAYGLERFWGEHLRLQRENQDKADYWKETWDELCRILRQAGIQIPNDPVSTENSAAIKTMTDKLWNFDQEQRKIALAILIELCDSLIWWTQRYKKPKQGVGGKTDAR
>NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYKKTYGIIETLAPLHVGATAGEESGNLNLIFRDQFTQTGILPGSSIRGRFRSEMRRDQSGDANYWYGSPAETGESDTTSESIVKFEYASLLWLPVFCPGQPIVWVSSPKLLKRYQRIAGNSVDGLKSIKTSAIDRLKYVGSSTLKTLNVEGKKKLFFNFGFLTLDKTEDLSIWFPNGEQLPAVVVGDDEIGMIHDMALYRQSRVRLMDREKRVDKGGFFNTEALPEGTIMVFPIAIRNTATTPWQPFGDGIETSEIYLGGLESIGFGNCQITLKNLNTVAHSQEVAA
>NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein
MFQHLITIAPLGLMYGSAGAFLSPENLVGRSGAKFPPDASTVAGLFFSANHSLKGAIAPHDTLKHNLHIAGPFWAKRDQPEVFYVPVPRHRIIAEEQEDEWRLEKHRWQRDLQKEDIEAFYTWQSIDAWNRETRQIRTNREAAQAPWKYVSFLHPQMKAEERHVLDQDGLFLENAVQMDEDYCLVYLSTHAFPEGWYRFGGEGHMVEINSQSLSPSSIIHQLLQTPIDRACALITPGVWGSHNLSYRYPRHPEFPREGMQMLTDKATPCRYRLGNRTTERGRLSRGRYAVPVGTVYVFKHPLNRCWWDFPDDWFPDKGLMKKLGSGLCLPIQIQGVA
>NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein
MPIYTAISFAPVQGFIEKSRKLRDLFGASLILSYLSQSLANAADQTPELKVISPALIHVQEGMPNRILIQGLFPRNEVEKVLIQAWDKVLQPCREWIETNVPVHDLYHWDAEWLRWKQYTWEIFWGKGDDPSAAMNDLERRKLKRDWVGINWTGESSSLTGTDAIAWHRLGEVRDPKHLLSEAEKRELKEFYRQLAWVLDDPHQRCGKIVDAGVEPEGKFIAANERLSLPELIKRLVTLPKLAKKIGLEDLAEGFKDIYREPGYWTGWFMGDGDQIGNKLKDIVQRYGDEKLEVFSHKMRSWGQTFQDDSTQFPQGKGRVIYAGGDDFLGVIYSEQNQSGEPAPEQVKPIDALNWLMQLPDQWQTLKTELWHDLEIEHTYSVGFVWAGHSVPQRDILQHCREAEKQAKSLGRDRVTIRIVFNNGQFIQWTCPWSYLSILTKYQDREGRTWGDAKLNWTHLYSDWEQLKARHAIRLTETDQYHADSYLALQLFNFYFDDAGKAIQKNPQDKRWKYLVGSNSELAIVQWIDSLIQIGWQLCSNI

Crispr_ID: NZ_AP018205_3

• CRISPR_ID: NZ_AP018205_3
• CRISPR_location: 55759-59005
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 42 spacers
• Cas_protein_info: csx18,cas1,cas2,csx1,cmr5gr11,cmr4gr7,cmr3gr5,cas10,WYL

Consensus repeat of NZ_AP018205_3

Consensus_repeat	Method
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	PILER-CR
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CRISPRCasFinder
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CRT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	PILER-CR

spacers of NZ_AP018205_3

>3.1|55795|41|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
TCTTATGACCATCGAAAGGCAGAATTACATCAATTCGATTC
>3.2|55872|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CAACATTGAACAGGATGCAGACACAATCCTGTTTATCTA
>3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
ATCAAAGAAATTAGATCAAGCTAGAAAAGATACAG
>3.4|56018|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
GCATCAATTTTATTGGCTCTGGTAATAGCAATGATCGTG
>3.5|56093|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
TGTAGCTTTACTTTCAGAGCATCCATTATTTAATATTTCA
>3.6|56169|48|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
TGGAGGTAGATATTAAATGCCAGTAATTAACAATAATGTACTTCTAGA
>3.7|56253|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CTCGTATGGTGGAGCGTTTGACTACTACCTTCTTAG
>3.8|56325|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CTCAGATCTTAATTCAGATTCTTGATCTTAGATTCAGATCTA
>3.9|56403|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
ACTCACGGCACCGAAGATCAACTTCGAGCAATACAAGTA
>3.10|56478|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
ATTCGCTCTGCGTTTGTGTCCAGTGAGCAATTTGCGCGG
>3.11|56553|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
TTGTGATGCAATCTTGGCACTCATAATCTGCACATCTTTCAT
>3.12|56631|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
ACTAAAACAATTAGATTTTGCGTTCTGTTCTTGGA
>3.13|56702|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CTCCCCACGTTTGAGGCTAAGACATGTGTGCTGTGCTGGC
>3.14|56778|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
TGAAAGACTAATTAGTATTGCTGCTGATACAAATTTG
>3.15|56851|45|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CAGATAAGCCTTTATCACCCAATCTATTCGATAAAAACCCATAAA
>3.16|56932|34|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CGGGTACACCTTCTATTGGATACAAGCTTGTGAT
>3.17|57002|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
GTCGCAATTCGCCGCAAGCTTCGTTGCCTGAACTGT
>3.18|57074|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
AAAACACTCGAACAAGTTGGACTCGCTTTGAACTTCA
>3.19|57147|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT
CCAGGAATTAGCCGAAATCAAAGCGGCTGCAAGTGA
>3.20|57219|36|NZ_AP018205|CRISPRCasFinder,CRT
ACCGCCGCAAGTAAGAAGTCTTTCGCTGATTAATGA
>3.21|57291|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
CTAGAGATGGGACATGCAGGGGATGAGGTATTTGACGAGCAGTTTGAA
>3.22|57375|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
ATGCCTATTTGGAAAATCTTTGGTAAGCAGAACGCTAACCGT
>3.23|57453|45|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TTGATCCTATCTATTTGGATGCAAATGGCAACTTTGATCCATTCC
>3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TACATATAGGTGGAGCGCCCGTCCCCCCGTGTGGGTGG
>3.25|57608|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TACAGTCGATTCAAACGCCCGATCAGCTCCCTTTACCCAA
>3.26|57684|52|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TCACGCTCGAAGTGATCACCACTTACTGAACTGCGACCTACGAATGCATCAA
>3.27|57772|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TTGCTAGCGGATTAGAAACAACGGTCACGAACATAGACAGAACT
>3.28|57852|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
AACAATGGTTATGGTTTAGAATCTGACACCGCAGTTGATG
>3.29|57928|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TTTCCAGCTAGGCTTCTAATTCCAGGTCGAGAAAAACAGC
>3.30|58004|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
GCAAATCCCCTGACACCTTGTCTGTCAGTTATGGCAAG
>3.31|58078|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
ATCGAGAGCGATGTATCAATTGCCAAATCGCTACAAACCAAC
>3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TCCATGACCACCGGAATGCCCTCAAAGACGGGGAACATCCGCG
>3.33|58235|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
AAGTTATTGAGTCAAAAATGATTCTTTCTGAAGGGCGTAAAAT
>3.34|58314|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
CATTCTTGAAGTTTCAAAGCAAAGGCACTAAGCGCTTCAT
>3.35|58390|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
CCGACCTTCAGTAAAGGATTTGAAGCTATGAAAGAGCTTTACA
>3.36|58469|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TAGAATATGGGGGGTGCACTAATGCAGATGGCATTCTCTGGTGA
>3.37|58549|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
ATCGAGACGTTGCAGCGGAACGGAAGACAGGGAAGAG
>3.38|58622|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
CTTAAAATAAGAATTAAAAAGTAGCTGAGTAAGTTACAAATGGTTCAG
>3.39|58706|41|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
CCCGATCACGCCACAATCACGCCACAATCGTAAACTGAGAA
>3.40|58783|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TTGCTGCGCGTTGGGGTTAGTAGTCAGCCGGATCGTAG
>3.41|58857|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
CTGGCTCTATGTCCGTTGCTTCTCGTTACGTTCTCGA
>3.42|58930|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR
TGGCATGAGAGCGTTACACCATTCCAGCAAGTAAGAGTTG

CRISPR arrays and Neighbor proteins around NZ_AP018205_3

CRISPR arrays

The CRISPR arrays of NZ_AP018205_3

>merge|NZ_AP018205|3|55759-59005|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTCTTATGACCATCGAAAGGCAGAATTACATCAATTCGATTCGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCAACATTGAACAGGATGCAGACACAATCCTGTTTATCTAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACATCAAAGAAATTAGATCAAGCTAGAAAAGATACAGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACGCATCAATTTTATTGGCTCTGGTAATAGCAATGATCGTGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTGTAGCTTTACTTTCAGAGCATCCATTATTTAATATTTCAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTGGAGGTAGATATTAAATGCCAGTAATTAACAATAATGTACTTCTAGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCTCGTATGGTGGAGCGTTTGACTACTACCTTCTTAGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCTCAGATCTTAATTCAGATTCTTGATCTTAGATTCAGATCTAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACACTCACGGCACCGAAGATCAACTTCGAGCAATACAAGTAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACATTCGCTCTGCGTTTGTGTCCAGTGAGCAATTTGCGCGGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTTGTGATGCAATCTTGGCACTCATAATCTGCACATCTTTCATGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACACTAAAACAATTAGATTTTGCGTTCTGTTCTTGGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCTCCCCACGTTTGAGGCTAAGACATGTGTGCTGTGCTGGCGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTGAAAGACTAATTAGTATTGCTGCTGATACAAATTTGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCAGATAAGCCTTTATCACCCAATCTATTCGATAAAAACCCATAAAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCGGGTACACCTTCTATTGGATACAAGCTTGTGATGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACGTCGCAATTCGCCGCAAGCTTCGTTGCCTGAACTGTGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACAAAACACTCGAACAAGTTGGACTCGCTTTGAACTTCAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCCAGGAATTAGCCGAAATCAAAGCGGCTGCAAGTGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACACCGCCGCAAGTAAGAAGTCTTTCGCTGATTAATGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCTAGAGATGGGACATGCAGGGGATGAGGTATTTGACGAGCAGTTTGAAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACATGCCTATTTGGAAAATCTTTGGTAAGCAGAACGCTAACCGTGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTTGATCCTATCTATTTGGATGCAAATGGCAACTTTGATCCATTCCGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTACATATAGGTGGAGCGCCCGTCCCCCCGTGTGGGTGGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTACAGTCGATTCAAACGCCCGATCAGCTCCCTTTACCCAAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTCACGCTCGAAGTGATCACCACTTACTGAACTGCGACCTACGAATGCATCAAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTTGCTAGCGGATTAGAAACAACGGTCACGAACATAGACAGAACTGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACAACAATGGTTATGGTTTAGAATCTGACACCGCAGTTGATGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTTTCCAGCTAGGCTTCTAATTCCAGGTCGAGAAAAACAGCGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACGCAAATCCCCTGACACCTTGTCTGTCAGTTATGGCAAGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACATCGAGAGCGATGTATCAATTGCCAAATCGCTACAAACCAACGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTCCATGACCACCGGAATGCCCTCAAAGACGGGGAACATCCGCGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACAAGTTATTGAGTCAAAAATGATTCTTTCTGAAGGGCGTAAAATGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCATTCTTGAAGTTTCAAAGCAAAGGCACTAAGCGCTTCATGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCCGACCTTCAGTAAAGGATTTGAAGCTATGAAAGAGCTTTACAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTAGAATATGGGGGGTGCACTAATGCAGATGGCATTCTCTGGTGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACATCGAGACGTTGCAGCGGAACGGAAGACAGGGAAGAGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCTTAAAATAAGAATTAAAAAGTAGCTGAGTAAGTTACAAATGGTTCAGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCCCGATCACGCCACAATCACGCCACAATCGTAAACTGAGAAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTTGCTGCGCGTTGGGGTTAGTAGTCAGCCGGATCGTAGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACCTGGCTCTATGTCCGTTGCTTCTCGTTACGTTCTCGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACTGGCATGAGAGCGTTACACCATTCCAGCAAGTAAGAGTTGGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC

>NZ_AP018205|3|3|55759-57218|PILER-CR
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCTTATGACCATCGAAAGGCAGAATTACATCAATTCGATTC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAACATTGAACAGGATGCAGACACAATCCTGTTTATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCAAAGAAATTAGATCAAGCTAGAAAAGATACAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCATCAATTTTATTGGCTCTGGTAATAGCAATGATCGTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGTAGCTTTACTTTCAGAGCATCCATTATTTAATATTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGAGGTAGATATTAAATGCCAGTAATTAACAATAATGTACTTCTAGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCGTATGGTGGAGCGTTTGACTACTACCTTCTTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCAGATCTTAATTCAGATTCTTGATCTTAGATTCAGATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTCACGGCACCGAAGATCAACTTCGAGCAATACAAGTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATTCGCTCTGCGTTTGTGTCCAGTGAGCAATTTGCGCGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGTGATGCAATCTTGGCACTCATAATCTGCACATCTTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTAAAACAATTAGATTTTGCGTTCTGTTCTTGGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCCCCACGTTTGAGGCTAAGACATGTGTGCTGTGCTGGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGAAAGACTAATTAGTATTGCTGCTGATACAAATTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAGATAAGCCTTTATCACCCAATCTATTCGATAAAAACCCATAAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CGGGTACACCTTCTATTGGATACAAGCTTGTGAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GTCGCAATTCGCCGCAAGCTTCGTTGCCTGAACTGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAAACACTCGAACAAGTTGGACTCGCTTTGAACTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCAGGAATTAGCCGAAATCAAAGCGGCTGCAAGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACACCGCCGCAAGTAAGAAGTCTTTCGCTGATTAATGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTAGAGATGGGACATGCAGGGGATGAGGTATTTGACGAGCAGTTTGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATGCCTATTTGGAAAATCTTTGGTAAGCAGAACGCTAACCGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGATCCTATCTATTTGGATGCAAATGGCAACTTTGATCCATTCC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACATATAGGTGGAGCGCCCGTCCCCCCGTGTGGGTGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACAGTCGATTCAAACGCCCGATCAGCTCCCTTTACCCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCACGCTCGAAGTGATCACCACTTACTGAACTGCGACCTACGAATGCATCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTAGCGGATTAGAAACAACGGTCACGAACATAGACAGAACT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AACAATGGTTATGGTTTAGAATCTGACACCGCAGTTGATG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTTCCAGCTAGGCTTCTAATTCCAGGTCGAGAAAAACAGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCAAATCCCCTGACACCTTGTCTGTCAGTTATGGCAAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGAGCGATGTATCAATTGCCAAATCGCTACAAACCAAC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCCATGACCACCGGAATGCCCTCAAAGACGGGGAACATCCGCG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAGTTATTGAGTCAAAAATGATTCTTTCTGAAGGGCGTAAAAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CATTCTTGAAGTTTCAAAGCAAAGGCACTAAGCGCTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCGACCTTCAGTAAAGGATTTGAAGCTATGAAAGAGCTTTACA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TAGAATATGGGGGGTGCACTAATGCAGATGGCATTCTCTGGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGACGTTGCAGCGGAACGGAAGACAGGGAAGAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTTAAAATAAGAATTAAAAAGTAGCTGAGTAAGTTACAAATGGTTCAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCCGATCACGCCACAATCACGCCACAATCGTAAACTGAGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTGCGCGTTGGGGTTAGTAGTCAGCCGGATCGTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTGGCTCTATGTCCGTTGCTTCTCGTTACGTTCTCGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGCATGAGAGCGTTACACCATTCCAGCAAGTAAGAGTTG


>NZ_AP018205|3|3|55759-59005|CRISPRCasFinder
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCTTATGACCATCGAAAGGCAGAATTACATCAATTCGATTC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAACATTGAACAGGATGCAGACACAATCCTGTTTATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCAAAGAAATTAGATCAAGCTAGAAAAGATACAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCATCAATTTTATTGGCTCTGGTAATAGCAATGATCGTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGTAGCTTTACTTTCAGAGCATCCATTATTTAATATTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGAGGTAGATATTAAATGCCAGTAATTAACAATAATGTACTTCTAGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCGTATGGTGGAGCGTTTGACTACTACCTTCTTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCAGATCTTAATTCAGATTCTTGATCTTAGATTCAGATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTCACGGCACCGAAGATCAACTTCGAGCAATACAAGTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATTCGCTCTGCGTTTGTGTCCAGTGAGCAATTTGCGCGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGTGATGCAATCTTGGCACTCATAATCTGCACATCTTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTAAAACAATTAGATTTTGCGTTCTGTTCTTGGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCCCCACGTTTGAGGCTAAGACATGTGTGCTGTGCTGGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGAAAGACTAATTAGTATTGCTGCTGATACAAATTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAGATAAGCCTTTATCACCCAATCTATTCGATAAAAACCCATAAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CGGGTACACCTTCTATTGGATACAAGCTTGTGAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GTCGCAATTCGCCGCAAGCTTCGTTGCCTGAACTGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAAACACTCGAACAAGTTGGACTCGCTTTGAACTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCAGGAATTAGCCGAAATCAAAGCGGCTGCAAGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACCGCCGCAAGTAAGAAGTCTTTCGCTGATTAATGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTAGAGATGGGACATGCAGGGGATGAGGTATTTGACGAGCAGTTTGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATGCCTATTTGGAAAATCTTTGGTAAGCAGAACGCTAACCGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGATCCTATCTATTTGGATGCAAATGGCAACTTTGATCCATTCC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACATATAGGTGGAGCGCCCGTCCCCCCGTGTGGGTGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACAGTCGATTCAAACGCCCGATCAGCTCCCTTTACCCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCACGCTCGAAGTGATCACCACTTACTGAACTGCGACCTACGAATGCATCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTAGCGGATTAGAAACAACGGTCACGAACATAGACAGAACT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AACAATGGTTATGGTTTAGAATCTGACACCGCAGTTGATG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTTCCAGCTAGGCTTCTAATTCCAGGTCGAGAAAAACAGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCAAATCCCCTGACACCTTGTCTGTCAGTTATGGCAAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGAGCGATGTATCAATTGCCAAATCGCTACAAACCAAC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCCATGACCACCGGAATGCCCTCAAAGACGGGGAACATCCGCG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAGTTATTGAGTCAAAAATGATTCTTTCTGAAGGGCGTAAAAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CATTCTTGAAGTTTCAAAGCAAAGGCACTAAGCGCTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCGACCTTCAGTAAAGGATTTGAAGCTATGAAAGAGCTTTACA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TAGAATATGGGGGGTGCACTAATGCAGATGGCATTCTCTGGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGACGTTGCAGCGGAACGGAAGACAGGGAAGAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTTAAAATAAGAATTAAAAAGTAGCTGAGTAAGTTACAAATGGTTCAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCCGATCACGCCACAATCACGCCACAATCGTAAACTGAGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTGCGCGTTGGGGTTAGTAGTCAGCCGGATCGTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTGGCTCTATGTCCGTTGCTTCTCGTTACGTTCTCGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGCATGAGAGCGTTACACCATTCCAGCAAGTAAGAGTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC

>NZ_AP018205|3|3|55759-59005|CRT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCTTATGACCATCGAAAGGCAGAATTACATCAATTCGATTC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAACATTGAACAGGATGCAGACACAATCCTGTTTATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCAAAGAAATTAGATCAAGCTAGAAAAGATACAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCATCAATTTTATTGGCTCTGGTAATAGCAATGATCGTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGTAGCTTTACTTTCAGAGCATCCATTATTTAATATTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGAGGTAGATATTAAATGCCAGTAATTAACAATAATGTACTTCTAGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCGTATGGTGGAGCGTTTGACTACTACCTTCTTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCAGATCTTAATTCAGATTCTTGATCTTAGATTCAGATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTCACGGCACCGAAGATCAACTTCGAGCAATACAAGTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATTCGCTCTGCGTTTGTGTCCAGTGAGCAATTTGCGCGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGTGATGCAATCTTGGCACTCATAATCTGCACATCTTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTAAAACAATTAGATTTTGCGTTCTGTTCTTGGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCCCCACGTTTGAGGCTAAGACATGTGTGCTGTGCTGGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGAAAGACTAATTAGTATTGCTGCTGATACAAATTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAGATAAGCCTTTATCACCCAATCTATTCGATAAAAACCCATAAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CGGGTACACCTTCTATTGGATACAAGCTTGTGAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GTCGCAATTCGCCGCAAGCTTCGTTGCCTGAACTGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAAACACTCGAACAAGTTGGACTCGCTTTGAACTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCAGGAATTAGCCGAAATCAAAGCGGCTGCAAGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACCGCCGCAAGTAAGAAGTCTTTCGCTGATTAATGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTAGAGATGGGACATGCAGGGGATGAGGTATTTGACGAGCAGTTTGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATGCCTATTTGGAAAATCTTTGGTAAGCAGAACGCTAACCGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGATCCTATCTATTTGGATGCAAATGGCAACTTTGATCCATTCC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACATATAGGTGGAGCGCCCGTCCCCCCGTGTGGGTGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACAGTCGATTCAAACGCCCGATCAGCTCCCTTTACCCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCACGCTCGAAGTGATCACCACTTACTGAACTGCGACCTACGAATGCATCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTAGCGGATTAGAAACAACGGTCACGAACATAGACAGAACT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AACAATGGTTATGGTTTAGAATCTGACACCGCAGTTGATG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTTCCAGCTAGGCTTCTAATTCCAGGTCGAGAAAAACAGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCAAATCCCCTGACACCTTGTCTGTCAGTTATGGCAAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGAGCGATGTATCAATTGCCAAATCGCTACAAACCAAC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCCATGACCACCGGAATGCCCTCAAAGACGGGGAACATCCGCG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAGTTATTGAGTCAAAAATGATTCTTTCTGAAGGGCGTAAAAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CATTCTTGAAGTTTCAAAGCAAAGGCACTAAGCGCTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCGACCTTCAGTAAAGGATTTGAAGCTATGAAAGAGCTTTACA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TAGAATATGGGGGGTGCACTAATGCAGATGGCATTCTCTGGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGACGTTGCAGCGGAACGGAAGACAGGGAAGAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTTAAAATAAGAATTAAAAAGTAGCTGAGTAAGTTACAAATGGTTCAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCCGATCACGCCACAATCACGCCACAATCGTAAACTGAGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTGCGCGTTGGGGTTAGTAGTCAGCCGGATCGTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTGGCTCTATGTCCGTTGCTTCTCGTTACGTTCTCGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGCATGAGAGCGTTACACCATTCCAGCAAGTAAGAGTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC

>NZ_AP018205|3|4|57255-59005|PILER-CR
	TCTTATGACCATCGAAAGGCAGAATTACATCAATTCGATTC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAACATTGAACAGGATGCAGACACAATCCTGTTTATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCAAAGAAATTAGATCAAGCTAGAAAAGATACAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCATCAATTTTATTGGCTCTGGTAATAGCAATGATCGTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGTAGCTTTACTTTCAGAGCATCCATTATTTAATATTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGAGGTAGATATTAAATGCCAGTAATTAACAATAATGTACTTCTAGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCGTATGGTGGAGCGTTTGACTACTACCTTCTTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCAGATCTTAATTCAGATTCTTGATCTTAGATTCAGATCTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTCACGGCACCGAAGATCAACTTCGAGCAATACAAGTA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATTCGCTCTGCGTTTGTGTCCAGTGAGCAATTTGCGCGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGTGATGCAATCTTGGCACTCATAATCTGCACATCTTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ACTAAAACAATTAGATTTTGCGTTCTGTTCTTGGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTCCCCACGTTTGAGGCTAAGACATGTGTGCTGTGCTGGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGAAAGACTAATTAGTATTGCTGCTGATACAAATTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CAGATAAGCCTTTATCACCCAATCTATTCGATAAAAACCCATAAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CGGGTACACCTTCTATTGGATACAAGCTTGTGAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GTCGCAATTCGCCGCAAGCTTCGTTGCCTGAACTGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAAACACTCGAACAAGTTGGACTCGCTTTGAACTTCA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCAGGAATTAGCCGAAATCAAAGCGGCTGCAAGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGACACCGCCGCAAGTAAGAAGTCTTTCGCTGATTAATGAGTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTAGAGATGGGACATGCAGGGGATGAGGTATTTGACGAGCAGTTTGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATGCCTATTTGGAAAATCTTTGGTAAGCAGAACGCTAACCGT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGATCCTATCTATTTGGATGCAAATGGCAACTTTGATCCATTCC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACATATAGGTGGAGCGCCCGTCCCCCCGTGTGGGTGG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TACAGTCGATTCAAACGCCCGATCAGCTCCCTTTACCCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCACGCTCGAAGTGATCACCACTTACTGAACTGCGACCTACGAATGCATCAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTAGCGGATTAGAAACAACGGTCACGAACATAGACAGAACT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AACAATGGTTATGGTTTAGAATCTGACACCGCAGTTGATG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTTCCAGCTAGGCTTCTAATTCCAGGTCGAGAAAAACAGC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	GCAAATCCCCTGACACCTTGTCTGTCAGTTATGGCAAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGAGCGATGTATCAATTGCCAAATCGCTACAAACCAAC
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TCCATGACCACCGGAATGCCCTCAAAGACGGGGAACATCCGCG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	AAGTTATTGAGTCAAAAATGATTCTTTCTGAAGGGCGTAAAAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CATTCTTGAAGTTTCAAAGCAAAGGCACTAAGCGCTTCAT
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCGACCTTCAGTAAAGGATTTGAAGCTATGAAAGAGCTTTACA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TAGAATATGGGGGGTGCACTAATGCAGATGGCATTCTCTGGTGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	ATCGAGACGTTGCAGCGGAACGGAAGACAGGGAAGAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTTAAAATAAGAATTAAAAAGTAGCTGAGTAAGTTACAAATGGTTCAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CCCGATCACGCCACAATCACGCCACAATCGTAAACTGAGAA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TTGCTGCGCGTTGGGGTTAGTAGTCAGCCGGATCGTAG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	CTGGCTCTATGTCCGTTGCTTCTCGTTACGTTCTCGA
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC	TGGCATGAGAGCGTTACACCATTCCAGCAAGTAAGAGTTG
GTTTCCATTCAATTAATTGCCTCTATTAAAAGAGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl|CDD|187810
NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	unknown
NZ_AP018205.1|WP_017291543.1|49804_50110_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291540.1|47541_48207_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NZ_AP018205.1|WP_086371089.1|59020_59212_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein	unknown	unknown	gnl|CDD|369567
NZ_AP018205.1|WP_017291539.1|46554_47403_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_026149057.1|50261_50882_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291557.1|68996_69242_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|224255
NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein	unknown	unknown	gnl|CDD|187792
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	gnl|CDD|226481
NZ_AP018205.1|WP_017291542.1|49101_49638_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|370625
NZ_AP018205.1|WP_017291555.1|66575_67715_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379100
NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein	unknown	unknown	gnl|CDD|178867
NZ_AP018205.1|WP_017291556.1|67900_68950_+|DUF91-domain-containing-protein	unknown	unknown	gnl|CDD|224552

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	4.1e-29	95.1	1.6
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	cas10	cd09679_cas10_CAS-III	7.1e-21	69.2	0.0
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	6.3e-89	292.8	0.1
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	5.9e-27	89.7	0.0
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.4e-30	100.1	0.7
NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	7.3e-99	326.6	6.7
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	3.1e-14	47.8	0.3
NZ_AP018205.1|WP_017291555.1|66575_67715_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	1.9e-22	74.8	0.2
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	4.9e-66	215.1	4.5

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.05506e-24
NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein	gnl|CDD|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	0.000752216
NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	8.84738e-107
NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein	gnl|CDD|369567	pfam07878, RHH_5, CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5. This family contains bacterial proteins that form a ribbon-helix-helix fold. This fold occurs in many examples of bacterial antitoxins.	5.91815e-09
NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.86841e-31
NZ_AP018205.1|WP_017291555.1|66575_67715_+|WYL-domain-containing-protein	gnl|CDD|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	7.35761e-12
NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein	gnl|CDD|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.40997e-18
NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein	gnl|CDD|178867	PRK00106, PRK00106, ribonuclease Y.	0.000748537
NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein	gnl|CDD|370625	pfam09700, Cas_Cmr3, CRISPR-associated protein (Cas_Cmr3). CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	1.11684e-08
NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein	gnl|CDD|226481	COG3972, COG3972, Superfamily I DNA and RNA helicases [General function prediction only].	0.000941883
NZ_AP018205.1|WP_017291556.1|67900_68950_+|DUF91-domain-containing-protein	gnl|CDD|224552	COG1637, COG1637, Predicted nuclease of the RecB family [DNA replication, recombination, and repair].	6.48765e-07

Protein sequences

>NZ_AP018205.1|WP_017291548.1|55113_55374_-|hypothetical-protein
MYLSNRALQVRNASIAGISGALTLVILLIAPLGLAAVIINTLLVTIATFATGTVVDRVVISMQRDRNLPPTADLRRRESSNVDRYR
>NZ_AP018205.1|WP_017291547.1|54123_55101_-|CRISPR-associated-endonuclease-Cas1
MKTLYVSHQGCYLSLRQESVLIKRGETILDQVQLPLLEQILIFGQSQVTTQVIRACLQRNIAIAYLSRMGKCYGRVLSITQGYRQLSRYQQLLSPELQLQTARIIVQAKLKNSRVILMRQQRRRASEQTALAIESLAYLVQQAGEAVSIARLMGLEGAGAASYFSAFGECLSGAGFVFLARSRRPPGNPVNAMLSFGYQVLWNHLLTLIELQGLDPYWGCLHQGHDRHAALASDLIEEFRSSIVDSLVLYLVNRGLVSADDDFEYHDGGCYLNQSGRRKFLQAFVQRMEESVEEQPRWNLLSQQVRAYKQFVYDPSCLYSPYLIR
>NZ_AP018205.1|WP_017291546.1|53828_54107_-|CRISPR-associated-endonuclease-Cas2
MLIYVVTYDIPSDKRRKKIADLLEGYGQRVQYSVFECALSAVKFKELRKRLQQRIKIEEDSVRMYPISQQMLQQVEVWGGVEIVEPPGSTIV
>NZ_AP018205.1|WP_026149057.1|50261_50882_+|hypothetical-protein
MATLGITKAITNLSEAHSRLGVSPSLDALTFFTEWKGTLPALTDTERARLDHLKQRYLYYADSGAITEGTVNLILLSPLLETLNFIDPPYQVRSEKYVRFEIEDGDTQLDGLIDALILQDRLWLILIESKRYGFSVRQALPQTLAYMVSAPTSPVFALITTGEDYLFVKFDRDSSRYALSDKLTLSTVEGNELHVVAQILKRLINS
>NZ_AP018205.1|WP_017291543.1|49804_50110_+|hypothetical-protein
MSSDSGSIEGNKTPRIDDFGVTVEEYLEGLAKGIDILEVRSLERWGIPSELVMELIEINKRVSNGTAKPEEVVRGLQIMSPPIRRQRINEQDAELIESDSP
>NZ_AP018205.1|WP_017291542.1|49101_49638_+|hypothetical-protein
MIEGRIMDEEMLRQQYEQTGNLLDILKNPAVMEEIIRLESEYGEIGAGFPAYSKNPQPVTPNQANAVMRKVRLQSMVLIDLAELIQSVNLGVGTEAAITEGRRRIREHLAHLTDEQQAYFDALVDEDQLQLLDKPLRARLKSVVHLLLSDSDWNAIGQAATNALQNQWNEFIRNSKTA
>NZ_AP018205.1|WP_017291541.1|48433_48817_+|hypothetical-protein
MSKRVFLTLPDGIADDLERWAASEKNKAATLAGFLVEEAVRRAKEQGKIPPDDGSFPHYDTLAELVRHNRNKLAESEKFSSARLKALSSGDKPTEVEILRLALILGRTEEYVLSLKTNPDVSEGSTN
>NZ_AP018205.1|WP_017291540.1|47541_48207_-|hypothetical-protein
MITTKAFKEQHDLSDSAFKRLVRKAKRQYPGGEFTRRINSTQWEVLHPAILESLISTTVAEPEFTDSTMTANKSASHLLQPLNLVPLHSLVPSHSQTVEVIPTSKVSTIADLNGQRDRLMQGQSEIEMALEVVQQTRQLVGYVLSVQRSQTTVDTQQVTQLEDAAFELQVHADCLRREDRRTSIEQGYRDQRRSEAQTQVVQMRDFFARRTEATASSEVQP
>NZ_AP018205.1|WP_017291539.1|46554_47403_-|hypothetical-protein
MLNRNQALQQNHPFYSHEVKSMPIRGKSKTAQDPNSALKSKSKKAKAETPSATEPTKTPKPTTAPTGILPTIALPLPNIPFRTTPPMTLSGGSSTAIHRKDLTQVNHGLDIPEFQPNQWMAKDLFTNSSPLPETSQAEADQAVLSIARKRQTLRIVRENIGLNRDIVGAATEHQQLLGAVIQYSTELVNNQTKFVKYTDAGVKQQIAAVKLSQSQEQFTQETIALDGLRQMTPLIQEEWNERLELRRAKINGLREQTLNANARLASKRQELEAMFNVEFQTI
>NZ_AP018205.1|WP_086371100.1|44978_46457_-|hypothetical-protein
MSFLGGIVSFILFLAAIAQQSRIAQSLSLLGLATSTGGIVACALSDRTNQTREEVEALTQRLSDRDLTLAAKDDRIVNLTAELNRVMAFVDHLKSAPISVDRTSHIVAQYQEKLNTLQARYRAEVERVKTEARSQHQTELDRLRSEMVAADTRIHEFEQRFLDRAQETLSEALTSFHDRISDLVMDNLRKLSHLEPETRDATFAERLQQLSEEVTDLHQTYVAQILNLSHFLDAENILDCSDEALSILYHLMDDYTSIKVKVINALKAKTIRELQTTIQAYQAADLVPKAQLEQLVKNLKLRLQEYELDAVQHQESVVAIANDYEAQTLEDDRIVRGYIDQLAKLEHDNHQLKEQVASLSALKKFDPGAWGWGADIGNQVIDYLMSENIPCDALPLDFSPTDSHLTIALNCRTEAGLRMLAKDGKEFEKGMAAAKGWSHVSLTLTGRVVKVTVQYANRAIAKTKPEAVLDRPISDWDLYLAAEYHWFIAAAC
>NZ_AP018205.1|WP_086371089.1|59020_59212_-|hypothetical-protein
MGISFEMEGVRGWGDLAERVIVSLGASMPYGIRVLPHCLGLKLMKLFVFGLSLANRCWTLSGD
>NZ_AP018205.1|WP_017291549.1|59282_60734_-|hypothetical-protein
MKIWLVTIGSSDVQLRTNDDWGDWYRVIRKDCHNLPFEPAQVIRDSAEPYRIAPRVLGIAYQAYPDEIWNALEFPLLKEFSIKLKDEAIDQIILLTTDQSYIFDENQRDDYKCPYWQDTSELQPILERYFQQHFPAVEVVLKVLAPQKGEFGLDDWNFVLDLVRSTLKELSGEPTAVYISHQAGTPAISSAVQFCSLARFRANVEFVVSNEYCPEQTRMISRSTYLRGLQTQEAKALLERYDYSGVKALLAPYLQAEVANLLEAAIQWNYAKFDRFAEHLQQAADIELAEFAKSRTTLENWWWTAYESAYLGFVRLKQGNTVEAMFHSFRSVEGLLRQWSNVLYGDEIKQTKHPRSEENQRWDRNLNAYGEDLYWFLTVKKSVDVTKNLKQNTTPDIFIFGNLVFKKRNDLFHQLKGLEGQEKVFENWQSPNEPKWKQDPEGHWKLRVLKCLNFICGENFSSLEEASLLVKVHQKIERAISQL
>NZ_AP018205.1|WP_017291550.1|60746_62444_-|hypothetical-protein
MPDSDYVPLMFQAQVQGRSLIHQVKDLKKEAERLAVRKETLRQQAYDWAEQWQESCDVDTVPNFGNDVRKSKEYIFTWRMVTNSGQDEGVIRPVIGERGWAYFPGSSMKGAFLRACRQLHPDRVNRYCGGSAQEGEVHPGILRFHGGYPKDGAWLKNSMVDIVHPQANWQVSGSKLSHETPKVLISLHQPTFVFGISSTEPVLESEWTEIWKIWEKALERGIGSRVSAGYGQVKTHGESKLISVGLSGQGIASRRLDLEGEFRPNGFKAALRGHTHRLFHGITDHKTVNHLIKQLWGGIGKGESATVGLLGVAFSAPELELDEWVAAGNPNNHVPVYETGDAILNVLVMKDGLRQEQRDELKNFVIRLVKFSMLLGGFGRSWRRSDHRLFLPRYKRQMIGCHWTFTKPSRKLYIPVSDDKLVSITRFLDLFYQKAQEFSWLNEIENRKTPDHSCREAWCKDNVQVWGRIADGEEDSIAIKWLHQDYKRGSSIKQSELTGSMKQIGRLWHRMYPRYLKRGEEWIETQEYIELLTIFPNRSGDKDEIQKTANFLKFLQDFTDFKQLW
>NZ_AP018205.1|WP_017291551.1|62433_62862_-|hypothetical-protein
MSWKMYEIDRCAHDLVLKFRDKKDVLNESHKMRVTTAYGLERFWGEHLRLQRENQDKADYWKETWDELCRILRQAGIQIPNDPVSTENSAAIKTMTDKLWNFDQEQRKIALAILIELCDSLIWWTQRYKKPKQGVGGKTDAR
>NZ_AP018205.1|WP_017291552.1|62858_63725_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYKKTYGIIETLAPLHVGATAGEESGNLNLIFRDQFTQTGILPGSSIRGRFRSEMRRDQSGDANYWYGSPAETGESDTTSESIVKFEYASLLWLPVFCPGQPIVWVSSPKLLKRYQRIAGNSVDGLKSIKTSAIDRLKYVGSSTLKTLNVEGKKKLFFNFGFLTLDKTEDLSIWFPNGEQLPAVVVGDDEIGMIHDMALYRQSRVRLMDREKRVDKGGFFNTEALPEGTIMVFPIAIRNTATTPWQPFGDGIETSEIYLGGLESIGFGNCQITLKNLNTVAHSQEVAA
>NZ_AP018205.1|WP_017291553.1|63724_64738_-|hypothetical-protein
MFQHLITIAPLGLMYGSAGAFLSPENLVGRSGAKFPPDASTVAGLFFSANHSLKGAIAPHDTLKHNLHIAGPFWAKRDQPEVFYVPVPRHRIIAEEQEDEWRLEKHRWQRDLQKEDIEAFYTWQSIDAWNRETRQIRTNREAAQAPWKYVSFLHPQMKAEERHVLDQDGLFLENAVQMDEDYCLVYLSTHAFPEGWYRFGGEGHMVEINSQSLSPSSIIHQLLQTPIDRACALITPGVWGSHNLSYRYPRHPEFPREGMQMLTDKATPCRYRLGNRTTERGRLSRGRYAVPVGTVYVFKHPLNRCWWDFPDDWFPDKGLMKKLGSGLCLPIQIQGVA
>NZ_AP018205.1|WP_017291554.1|64722_66351_-|hypothetical-protein
MPIYTAISFAPVQGFIEKSRKLRDLFGASLILSYLSQSLANAADQTPELKVISPALIHVQEGMPNRILIQGLFPRNEVEKVLIQAWDKVLQPCREWIETNVPVHDLYHWDAEWLRWKQYTWEIFWGKGDDPSAAMNDLERRKLKRDWVGINWTGESSSLTGTDAIAWHRLGEVRDPKHLLSEAEKRELKEFYRQLAWVLDDPHQRCGKIVDAGVEPEGKFIAANERLSLPELIKRLVTLPKLAKKIGLEDLAEGFKDIYREPGYWTGWFMGDGDQIGNKLKDIVQRYGDEKLEVFSHKMRSWGQTFQDDSTQFPQGKGRVIYAGGDDFLGVIYSEQNQSGEPAPEQVKPIDALNWLMQLPDQWQTLKTELWHDLEIEHTYSVGFVWAGHSVPQRDILQHCREAEKQAKSLGRDRVTIRIVFNNGQFIQWTCPWSYLSILTKYQDREGRTWGDAKLNWTHLYSDWEQLKARHAIRLTETDQYHADSYLALQLFNFYFDDAGKAIQKNPQDKRWKYLVGSNSELAIVQWIDSLIQIGWQLCSNI
>NZ_AP018205.1|WP_017291555.1|66575_67715_+|WYL-domain-containing-protein
MKLHPYSESDTFIRLMLLIATFVHHPGVGATPAIGANGTHDAMQLVLAQMQHVAHTLGFALPDYSVHTLRKDLKTLRQYGILDQRMYRWGYYLGTGALTQSELSIALQALAAQAQGDAALKQTYETLERRLRGLNLELEGQLLYPVRTQLQRSIIYTDPVEMMQQGHYRQTLFDHIERLQSAILQGLPIELCQRSNPYVPEETGQRLRVYGLQLVYADIAWYLLCEHLDNEHLSIVRLDRLSDHFQILNPQGRGLEQQFQSLQIAHQLLTTGWGLYLGSVEAQQQERLAQLEPIAVLVRFFPPVVDFILEGERRHPTQKVRRGKHGSYVDYHVTLPERSLSEFLHWVNRFMGAAEILAPASLQERHYQSAIALVQRYET
>NZ_AP018205.1|WP_017291556.1|67900_68950_+|DUF91-domain-containing-protein
MVSINSNLNPHWRFQSEAHLEDFVWNNLSALFNLKGLARQYSLHHQVCDILAIDQSGQITIIELKNSIDRYIIQQLTRYFNAVVSQRPFLDQIDYQQPVRLIAIAPSFHAHNLVDQAYHQLSFELYTFAISSCNHGKLYFELRDSGAEQLIRLEIPEPFHPLIDRVEQHNTAQLAIAPAPPKSLANLLNALTQEQQAYVLSIREQLLEFDPAMIEVGKTTRTIYGLRKNKKDIYQTKLCAEIIPVALGVMRPRLRLQLPYLKRTLSRVSSDNSQKLVKGLTWVEVRHRREWDKTTAIQLLFYFGKGCSHHSYSLSLDEYSKVYQQLAGQYCSLQSLEDVMIVALEEWKA
>NZ_AP018205.1|WP_017291557.1|68996_69242_+|hypothetical-protein
MKPEQIVKAFGVAKSWDECRGLQIPSFFKKPRLSPYQPHQGTHFIQKYRVLVASIKLAQAYQVEQSQIIHTLDKLDAFILS

Crispr_ID: NZ_AP018205_4

• CRISPR_ID: NZ_AP018205_4
• CRISPR_location: 138837-138958
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018205_4

Consensus_repeat	Method
TGAGGTATGTACCGTAGCACTACAGTACACGAAA	CRISPRCasFinder

spacers of NZ_AP018205_4

>4.1|138871|54|NZ_AP018205|CRISPRCasFinder
TTCAGCTTGTTGAATCAGATTAAGTCCTCCATTTTCAGTTAAGCTCTCTATGAA

CRISPR arrays and Neighbor proteins around NZ_AP018205_4

CRISPR arrays

The CRISPR arrays of NZ_AP018205_4

>merge|NZ_AP018205|4|138837-138958|CRISPRCasFinder
TGAGGTATGTACCGTAGCACTACAGTACACGAAATTCAGCTTGTTGAATCAGATTAAGTCCTCCATTTTCAGTTAAGCTCTCTATGAATGAGGTATGTACCGTAGCACTACAGTACGCGAAA

>NZ_AP018205|4|4|138837-138958|CRISPRCasFinder
TGAGGTATGTACCGTAGCACTACAGTACACGAAA	TTCAGCTTGTTGAATCAGATTAAGTCCTCCATTTTCAGTTAAGCTCTCTATGAA
TGAGGTATGTACCGTAGCACTACAGTACGCGAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018205.1|WP_017291630.1|143993_144593_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291621.1|136287_136509_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_AP018205.1|WP_017291623.1|137991_138819_-|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NZ_AP018205.1|WP_017291627.1|142648_142846_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291625.1|139767_140670_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NZ_AP018205.1|WP_017291624.1|139177_139585_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291620.1|135034_136240_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_096735604.1|145440_146570_-|IS3-family-transposase	unknown	unknown	gnl|CDD|222853
NZ_AP018205.1|WP_017291631.1|144861_145326_-|hypothetical-protein	unknown	unknown	gnl|CDD|227946
NZ_AP018205.1|WP_017291634.1|146587_147412_-|IS701-family-transposase	unknown	unknown	gnl|CDD|379252
NZ_AP018205.1|WP_017291629.1|143350_144001_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291619.1|133482_134337_-|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NZ_AP018205.1|WP_017291618.1|132974_133490_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291615.1|129481_130381_-|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
NZ_AP018205.1|WP_017291622.1|136832_138023_-|hypothetical-protein	unknown	unknown	gnl|CDD|319254
NZ_AP018205.1|WP_017291628.1|142898_143360_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_026148520.1|131974_132886_+|IS982-family-transposase	unknown	unknown	gnl|CDD|372648
NZ_AP018205.1|WP_017291626.1|140666_141365_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018205.1|WP_017291616.1|130475_131297_-|JAB-domain-containing-protein	unknown	unknown	gnl|CDD|178801
NZ_AP018205.1|WP_017291617.1|131322_131811_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018205.1|WP_017291621.1|136287_136509_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.72078e-10
NZ_AP018205.1|WP_017291623.1|137991_138819_-|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	3.27137e-33
NZ_AP018205.1|WP_017291625.1|139767_140670_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	7.61026e-29
NZ_AP018205.1|WP_017291615.1|129481_130381_-|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	3.38142e-13
NZ_AP018205.1|WP_017291631.1|144861_145326_-|hypothetical-protein	gnl|CDD|227946	COG5659, COG5659, FOG: Transposase [DNA replication, recombination, and repair].	1.66898e-13
NZ_AP018205.1|WP_017291616.1|130475_131297_-|JAB-domain-containing-protein	gnl|CDD|178801	PRK00024, PRK00024, DNA repair protein RadC.	1.84881e-94
NZ_AP018205.1|WP_017291622.1|136832_138023_-|hypothetical-protein	gnl|CDD|319254	cd16396, Noc_N, nucleoid occlusion protein, N-terminal domain, and related domains of the ParB partitioning protein family. Nucleoid occlusion protein has been shown in Bacillus subtilis to bind to specific DNA sequences on the chromosome (Noc-binding DNA sequences, NBS), inhibiting cell division near the nucleoid and thereby protecting the chromosome. This N-terminal domain is related to the N-terminal domain of ParB/repB partitioning system proteins.	1.55748e-11
NZ_AP018205.1|WP_096735604.1|145440_146570_-|IS3-family-transposase	gnl|CDD|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.42966e-48
NZ_AP018205.1|WP_026148520.1|131974_132886_+|IS982-family-transposase	gnl|CDD|372648	pfam13612, DDE_Tnp_1_3, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.07919e-92
NZ_AP018205.1|WP_017291619.1|133482_134337_-|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	2.12447e-40
NZ_AP018205.1|WP_017291634.1|146587_147412_-|IS701-family-transposase	gnl|CDD|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.1262e-48

Protein sequences

>NZ_AP018205.1|WP_017291623.1|137991_138819_-|ParA-family-protein
MAKQIRLAIMTGAGGVGKTTLAANLGYEIARLGYKVGLFDLDPQGSLNVACRLNKTPAPKTTCAWIFSGFFDGTYSFVPVWSNHVKTLEVLQGGNALFKVMPNLAQTGGVDLLKDAIEQYPLPHDLIIFDCPATLETIPKAALVAATHLLIPLVPDAKAIDGTRVLLDWYAASIQELKLDSPPKILGFVINNVENGAEHQRLSQELPPYYKARGYEVFPMIRHYTAFTNAWSEGVPLRVHRTSHPAIEPLEAIVNNIVKELGGKQRGKARSTRHR
>NZ_AP018205.1|WP_017291622.1|136832_138023_-|hypothetical-protein
MAKRDRLDIDNFFSEVDQNQELHNLRGKVQSLEEELSQNVEREQQLVSEIEHLRSQMLDPKEQAQLETQIGVLRDHLKGTQGVVKYPVNKVHRNPNQPRQTFDEEVEAMRLSLLKEGQLDPIILFEDGMLFDGECRWRSAEAMGWETIDAVFTARPQDDKTLRRRAYLTSLHRRGLNALDKAETLVAIASDEIPDLPQEDVSRIVNRVLIRLKRKNQSLGDRLHLQPQEEQQRVLEELGLEEIEVQTFLVFLGLQEHPASLNRNIFPTLNLFDDLKAAIRTQRLGCPQALLLNGLSAQKLGITEKQALKLRQKAIKEVTSRNLSTIETRRWVAEQRKQSSKSGEAEDSSGEHRNEQVDQVIHVIRDLSLKDALPVEQRNELKTVLKNVLAQLEKMV
>NZ_AP018205.1|WP_017291621.1|136287_136509_-|helix-turn-helix-transcriptional-regulator
MTFSEWLCFKRKRSQIRQKDLASALGLSKQTISSWETGESFPKLTPLQMQILCEKLDCSLSELASYQAVAEAP
>NZ_AP018205.1|WP_017291620.1|135034_136240_+|hypothetical-protein
MHSTQSSSPIEGGYCLLSQATLTNVLGALIDRAISYRAARVFFACCSMRSIREAAARCQIRKHQKIQFRFDEIRQRVGTQSEKLIRADLKQLERSGLLSFTQDAIEVVTVPINFTQSFDLGRSMRRLIPVPRRILEYLAQCPSPSVLRGIIVYVLRGLTLRQGIVYACGSVKSSWVAQIAHISLRAAKSVRAHLIEIGWLTKDTGSTQRKLNATGAFFRINTQWRRSSSTTKQPRAVDNSTTSDSQSAPLIAKLGSKSAPPIQDLKTSTNSKDQKSSKSLPGVYQQTQKISPPILHNIQANDLYHFHRLELLYWQAIAAKWLIHSEASTLNWICAAVRAREVVKRSGGNAVKVFVTIVRRKLWNTITGTQEDYARKSLVRFRETCPQLFRHRSESDRRISV
>NZ_AP018205.1|WP_017291619.1|133482_134337_-|ParA-family-protein
MKRQHQTLVIGIGNQKGGVGKTTMTIQLAYALAEQGHKVLIIDLDVNAGSTKHLGIDPRAYLGTFEVLLGDEDPLTAIVTHEDEGHSLPESLHLLTGSRKLEELEERLRAKKSKFDDTPLHDVLKPVIKKLRGYYDFIFLDTPPSAPLPIVAAYKAADGFLLVAIPEGLAIQGLQEALHDIEEVRKYGNPDLQLVGLAIGAVDARTRLSRELIAYVDKEFKEYVLKPVIQRSTIIPTAQTQQKSIFQTHPDHAITQCFRDMAQEFKAKIARFFDRQTFDEVDHG
>NZ_AP018205.1|WP_017291618.1|132974_133490_-|hypothetical-protein
MGKRATVLDVNYNPVGSRLQRVISPLSDLDQSLTVPQDSEPLDQSKPTELDEGAGNSQSSLTAMARSQPKAGERREIMSSEIRVRCTNSERKKWQDFAYRLTGEPNTFSHIFRALLVLLEHAEEDFGRMSELVRLLTKPPKNDPLQVALFEHKIAQILWESMRRSGRVERK
>NZ_AP018205.1|WP_026148520.1|131974_132886_+|IS982-family-transposase
MEPIVSRLDLTALFCDVDDFCQTFEWAWAHQPQLPSMPGEKRSRSRLRLSEVMTIVIAFHASGARTFKDFYTLTVLPHWRKAFPNLVSYTRFVELMPWCLMLLCCFLMTRRGEMTGIAFVDSTPIEVCHPARAHSHKVFKHQVGWGKSSTGWKFGFKLHLIINEHGELLAFKLTPANTDDRAPVAEMTEGIFGKLFGDRGYISQKLFEELYERGLKLITKRKRNMKQKLVTLMDKILLRKRSLIESVNDQLKNICQIEHSRHRSYWNFLVNLMAGLIAYTYQPKLPSLDLQPKGLPALPPAIF
>NZ_AP018205.1|WP_017291617.1|131322_131811_-|hypothetical-protein
MSRDQFEAIVIRNFLNAETMSRYLKVDVSVIEAWINDQAAIPDAAIMLLMQLDSLLSQACEHVIQTARSQSTATMPLSTIPIITYLTESDFQIYCEDAQILGSVGIHQGFVMRVISELRHLGFNAYRVPFDQHQYLSWLQSEGYINSSASRLLWAAEQRFDN
>NZ_AP018205.1|WP_017291616.1|130475_131297_-|JAB-domain-containing-protein
MREEIHHSLETDWADFSISPTLKSSYAAAKRSSDPTLTLRHYPQGETPRERLLTEGAGHLSNTELLAILLGSGNASQGESAVALAQKLLAHLQNHLDDATRSLREAKPEILMQVNGIGEAKAATILAAIELGRRLFLQSPPIGTVIDSPELAAQALSKNLMFQPQERFAVLLLNIKHQLLGQQLIAIGSGNQTCVHPPDVFREAIRQNAARLIIAHNHPSGNLTPSSEDIALTKQLLDAGQLLMLPVLDHLILGNGDFLSLRTTTTLWSEISS
>NZ_AP018205.1|WP_017291615.1|129481_130381_-|N-6-DNA-methylase
MSGKKQKVIATFEDAQRSFRSILEEVSAHRAPRDLFRDFLEVASIVVSQMPYNAGAIPKDERFNEREAQYFAIAKRHSEKEMNAFASLLGMTTFAVQTFERDFLGPIYMDFGANERNGEFYTPESLGITMARMTLTRSFLESILNQKKLITISDPACGSGGLLIEAYQVIKEELQIDDASDRVLFHAVDVSRNAFNMCVIQLGLLGVMADIYHGNTLTLETFEHRDTPALALWRHQCRTDPALRMLLFLRQLEQETCANRLIEQPNDGDAIAEEAVAASKLEASEADVTFTPQQLKLFE
>NZ_AP018205.1|WP_017291624.1|139177_139585_+|hypothetical-protein
MDSSRRRIVVPISLQPADRARLEELRSRFATILKSNINTSETVRLAISIGSAASHEQVRQVVLQTTRIPRGRPPIPWTARYLDDQEEEWVREEQERLQRLRLIHELQVLRSYLVRTSDQEKRLEEICRELNMVLA
>NZ_AP018205.1|WP_017291625.1|139767_140670_+|ParB/RepB/Spo0J-family-partition-protein
MKAENDAVAINLVEDVDTKQNVQLIPLNCIQVGKQSRTYFSPHSLNLLAQSFQRYGFQGVINVRYIDRDCYEVVAGERRLRAAKLAGLKAVQCIVGDFTPEEALEFALRENLQREDLSKLEETEALLALLSLKLKLEQSHIIEVINKEGHLDRQKNNQPKSTELQQIESLLGSFGIELQTFRTKNLRTLTLPYEIRQAHLEGGLPYSSALEIGKVKDPTVRANVLQEALAQGYSVRDVQSIVQQVAQPSSRETLKPSDRVHAIARRLKKVEASIRDRVKLDQVIDQFIDVLEEIVKDRAS
>NZ_AP018205.1|WP_017291626.1|140666_141365_-|hypothetical-protein
MEIGKYADGNWIGARFLRIEPRGFTLNQFSFFRRVIAMSYSFVVIELHVLIRRVAIDYVRFGYYRYAMREIPAGKDPLHVDAKLIETYDITQCRMTRTRRKRQGLANVVFVRQGHRFILLATEGKHPAFDRICWRDIRIAPIHFAGYSIGMKGGVPCVQVARRTWKPIERYLFAIAHRPKSEVEAAMNNLRFYSFPGVIRQKLKLVKTMNRMRRKSHRPRVELHLRLERKAD
>NZ_AP018205.1|WP_017291627.1|142648_142846_-|hypothetical-protein
MKQTASITILNAPDSANPPSTIATPIPTPAARRYVKDFARLAFASTQTVAPACHRPCAKSEDFGK
>NZ_AP018205.1|WP_017291628.1|142898_143360_+|hypothetical-protein
MVQGAGAETAIAAKLIPLVQQRWKFKFNQPVPRYGDVNVFAISPNGNLYPIKVKAIKGKVHCEGGRLFVLPNSIRERSFGGRNLLLQCRGQAEAIRVQYRIRNVYLILCFANAVMDLKVSSIDGVEIVTGADVVERLQLLDRQLNMMNSTPYC
>NZ_AP018205.1|WP_017291629.1|143350_144001_-|hypothetical-protein
MDERQRLHAALQEALVAPVKADCRSLCQLLEDAIALQPDAVCLQIGGDAIALIAEVLYLKMMAYQEVNKTDVPDEEDSGFPVLDDDDHAYERHTMSLDLESDEEEWGKPKKVASRRAPNDSVAAPVPPKRVLKMLQDLAGDEDPTGWSVAISAWLKRKKINEPIPIAQIHQSMRKLSIVELWLGLLLGGFLIEEKPNTDETFYHDISDGAVWLIQQ
>NZ_AP018205.1|WP_017291630.1|143993_144593_-|hypothetical-protein
MLWAVSKTWQNARQGNRSMARPINPKCLECSAYSVEWARVEHGPNGDGCWVEEENRCEKLRWQYQNRAEQNAKRRLEYRLRQQAKQTVAQVSFPVAQRPTPIRIIFSEEPDNFKKNVTLVHAIEFQLWVGTECYTKREPIACWGMRGDEVAKLMEEILTEFTAQYSATLNQGKHFKKFVTIHKHIRECKINHPWSLQHG
>NZ_AP018205.1|WP_017291631.1|144861_145326_-|hypothetical-protein
MPPEQWQRLSCGQGSKGEREYEWARVAINCGDSGRFQRWLVFRRSLEQIDPPQHVSYYQVFAPKDTSLATIAKVAGKRWGIEECFKLAKSQLGLADYEVRSWVGWHRHMTLVLAAQAFLTVLRAQVEPLIQCSHSASPPLALVGSPVAFKVFRG
>NZ_AP018205.1|WP_096735604.1|145440_146570_-|IS3-family-transposase
MSNQAKKYSPQFKAKVVLELLRGEKTQTEISRAHGVHRSVLTRWQNEFVERASSVFGEVGQVSEVESRIAELEQMVGKLTMQLEIAKKASSNLSDETKRQIVAELEPHYSVRQICEVLSVNRSSLYYQPVEEELATETELKSAIDKIAGEFPRYGYRRITQQLKRQGIVVNHKRVARMMKEMGIAGKAPKRRCRTTNSNHSFARYPNRVAGLKIERPNQVWVSDITYIRLGEGFVYLAVLMDVFTRCIRGWHLGRGLDHSLTLTALNKALEHYQPEIHHSDQGVQYAATGYVEVLKQRKIEISMAEVGEPTQNGYAERLMRTIKEEEVDLSEYRNFAEVYMQVKVFLEEVYMRKRIHSSIGYLTPIEFESEWRSNQ
>NZ_AP018205.1|WP_017291634.1|146587_147412_-|IS701-family-transposase
MDRLSIDPSQVFLTGQALETVYEWSNTLKSFQQRLSPYFARTEARQAAFNYIQALLSPVERKNGWQIAEQVGNENPYRVQHLLGRAQWDAEKVCQEVRQYGVEGLSESDDIFAVDETGFLKQGHQSVGVQVQYYGTTGHLENCQVGVFLAYITGKSHTLIDRRLYLPKSWADDADKRSKAGVPKTVKFATKAQLAQQMLQAAWDAGLRSAWVVADEVYGNDAGFWWWLEKTGQQPYVLTVNKKQPVVIGWQPNRAEAVKCPPKTRPLQERQETV

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP018205_3	3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58156-58198	43	NZ_AP018203.1	468440-468482	0	1.0
NZ_AP018205_3	3.42|58930|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58930-58969	40	NZ_AP018203.1	2512702-2512741	0	1.0

1. spacer 3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to position: 468440-468482, mismatch: 0, identity: 1.0

tccatgaccaccggaatgccctcaaagacggggaacatccgcg	CRISPR spacer
tccatgaccaccggaatgccctcaaagacggggaacatccgcg	Protospacer
*******************************************

2. spacer 3.42|58930|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to position: 2512702-2512741, mismatch: 0, identity: 1.0

tggcatgagagcgttacaccattccagcaagtaagagttg	CRISPR spacer
tggcatgagagcgttacaccattccagcaagtaagagttg	Protospacer
****************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP018205_1	1.1|51346|42|NZ_AP018205|CRT	51346-51387	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	454039-454080	0	1.0
NZ_AP018205_1	1.1|51346|42|NZ_AP018205|CRT	51346-51387	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51346-51387	0	1.0
NZ_AP018205_1	1.2|51424|37|NZ_AP018205|CRT,CRISPRCasFinder	51424-51460	37	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453966-454002	0	1.0
NZ_AP018205_1	1.2|51424|37|NZ_AP018205|CRT,CRISPRCasFinder	51424-51460	37	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51424-51460	0	1.0
NZ_AP018205_1	1.3|51497|36|NZ_AP018205|CRT,CRISPRCasFinder	51497-51532	36	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453894-453929	0	1.0
NZ_AP018205_1	1.3|51497|36|NZ_AP018205|CRT,CRISPRCasFinder	51497-51532	36	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51497-51532	0	1.0
NZ_AP018205_1	1.4|51569|35|NZ_AP018205|CRT,CRISPRCasFinder	51569-51603	35	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453823-453857	0	1.0
NZ_AP018205_1	1.4|51569|35|NZ_AP018205|CRT,CRISPRCasFinder	51569-51603	35	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51569-51603	0	1.0
NZ_AP018205_1	1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder	51640-51672	33	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453754-453786	0	1.0
NZ_AP018205_1	1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder	51640-51672	33	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51640-51672	0	1.0
NZ_AP018205_1	1.6|51347|42|NZ_AP018205|PILER-CR	51347-51388	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	454039-454080	0	1.0
NZ_AP018205_1	1.6|51347|42|NZ_AP018205|PILER-CR	51347-51388	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51346-51387	0	1.0
NZ_AP018205_1	1.7|51425|37|NZ_AP018205|PILER-CR	51425-51461	37	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453966-454002	0	1.0
NZ_AP018205_1	1.7|51425|37|NZ_AP018205|PILER-CR	51425-51461	37	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51424-51460	0	1.0
NZ_AP018205_1	1.8|51498|36|NZ_AP018205|PILER-CR	51498-51533	36	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453894-453929	0	1.0
NZ_AP018205_1	1.8|51498|36|NZ_AP018205|PILER-CR	51498-51533	36	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51497-51532	0	1.0
NZ_AP018205_1	1.9|51570|35|NZ_AP018205|PILER-CR	51570-51604	35	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453823-453857	0	1.0
NZ_AP018205_1	1.9|51570|35|NZ_AP018205|PILER-CR	51570-51604	35	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51569-51603	0	1.0
NZ_AP018205_1	1.10|51641|33|NZ_AP018205|PILER-CR	51641-51673	33	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453754-453786	0	1.0
NZ_AP018205_1	1.10|51641|33|NZ_AP018205|PILER-CR	51641-51673	33	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	51640-51672	0	1.0
NZ_AP018205_2	2.1|52150|46|NZ_AP018205|CRISPRCasFinder,CRT	52150-52195	46	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453231-453276	0	1.0
NZ_AP018205_2	2.1|52150|46|NZ_AP018205|CRISPRCasFinder,CRT	52150-52195	46	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52150-52195	0	1.0
NZ_AP018205_2	2.2|52232|39|NZ_AP018205|CRISPRCasFinder,CRT	52232-52270	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52232-52270	0	1.0
NZ_AP018205_2	2.2|52232|39|NZ_AP018205|CRISPRCasFinder,CRT	52232-52270	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453156-453194	0	1.0
NZ_AP018205_2	2.3|52307|41|NZ_AP018205|CRISPRCasFinder,CRT	52307-52347	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453079-453119	0	1.0
NZ_AP018205_2	2.3|52307|41|NZ_AP018205|CRISPRCasFinder,CRT	52307-52347	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52307-52347	0	1.0
NZ_AP018205_2	2.4|52384|52|NZ_AP018205|CRISPRCasFinder,CRT	52384-52435	52	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52384-52435	0	1.0
NZ_AP018205_2	2.4|52384|52|NZ_AP018205|CRISPRCasFinder,CRT	52384-52435	52	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452991-453042	0	1.0
NZ_AP018205_2	2.5|52472|39|NZ_AP018205|CRISPRCasFinder,CRT	52472-52510	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52472-52510	0	1.0
NZ_AP018205_2	2.5|52472|39|NZ_AP018205|CRISPRCasFinder,CRT	52472-52510	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452916-452954	0	1.0
NZ_AP018205_2	2.6|52547|43|NZ_AP018205|CRISPRCasFinder,CRT	52547-52589	43	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452837-452879	0	1.0
NZ_AP018205_2	2.6|52547|43|NZ_AP018205|CRISPRCasFinder,CRT	52547-52589	43	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52547-52589	0	1.0
NZ_AP018205_2	2.7|52626|46|NZ_AP018205|CRISPRCasFinder,CRT	52626-52671	46	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52626-52671	0	1.0
NZ_AP018205_2	2.7|52626|46|NZ_AP018205|CRISPRCasFinder,CRT	52626-52671	46	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452755-452800	0	1.0
NZ_AP018205_2	2.8|52708|40|NZ_AP018205|CRISPRCasFinder,CRT	52708-52747	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452679-452718	0	1.0
NZ_AP018205_2	2.8|52708|40|NZ_AP018205|CRISPRCasFinder,CRT	52708-52747	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52708-52747	0	1.0
NZ_AP018205_2	2.9|52784|46|NZ_AP018205|CRISPRCasFinder,CRT	52784-52829	46	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452597-452642	0	1.0
NZ_AP018205_2	2.9|52784|46|NZ_AP018205|CRISPRCasFinder,CRT	52784-52829	46	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52784-52829	0	1.0
NZ_AP018205_2	2.10|52866|41|NZ_AP018205|CRISPRCasFinder,CRT	52866-52906	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452520-452560	0	1.0
NZ_AP018205_2	2.10|52866|41|NZ_AP018205|CRISPRCasFinder,CRT	52866-52906	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52866-52906	0	1.0
NZ_AP018205_2	2.11|52943|49|NZ_AP018205|CRISPRCasFinder,CRT	52943-52991	49	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452435-452483	0	1.0
NZ_AP018205_2	2.11|52943|49|NZ_AP018205|CRISPRCasFinder,CRT	52943-52991	49	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52943-52991	0	1.0
NZ_AP018205_2	2.12|53028|41|NZ_AP018205|CRISPRCasFinder,CRT	53028-53068	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53028-53068	0	1.0
NZ_AP018205_2	2.12|53028|41|NZ_AP018205|CRISPRCasFinder,CRT	53028-53068	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452358-452398	0	1.0
NZ_AP018205_2	2.13|53105|40|NZ_AP018205|CRISPRCasFinder,CRT	53105-53144	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452282-452321	0	1.0
NZ_AP018205_2	2.13|53105|40|NZ_AP018205|CRISPRCasFinder,CRT	53105-53144	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53105-53144	0	1.0
NZ_AP018205_2	2.14|53181|41|NZ_AP018205|CRISPRCasFinder,CRT	53181-53221	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452205-452245	0	1.0
NZ_AP018205_2	2.14|53181|41|NZ_AP018205|CRISPRCasFinder,CRT	53181-53221	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53181-53221	0	1.0
NZ_AP018205_2	2.15|53258|41|NZ_AP018205|CRISPRCasFinder,CRT	53258-53298	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452128-452168	0	1.0
NZ_AP018205_2	2.15|53258|41|NZ_AP018205|CRISPRCasFinder,CRT	53258-53298	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53258-53298	0	1.0
NZ_AP018205_2	2.16|53335|38|NZ_AP018205|CRISPRCasFinder,CRT	53335-53372	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53335-53372	0	1.0
NZ_AP018205_2	2.16|53335|38|NZ_AP018205|CRISPRCasFinder,CRT	53335-53372	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452054-452091	0	1.0
NZ_AP018205_2	2.17|53409|41|NZ_AP018205|CRISPRCasFinder,CRT	53409-53449	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53409-53449	0	1.0
NZ_AP018205_2	2.17|53409|41|NZ_AP018205|CRISPRCasFinder,CRT	53409-53449	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	451977-452017	0	1.0
NZ_AP018205_2	2.18|53486|38|NZ_AP018205|CRISPRCasFinder,CRT	53486-53523	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	451903-451940	0	1.0
NZ_AP018205_2	2.18|53486|38|NZ_AP018205|CRISPRCasFinder,CRT	53486-53523	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53486-53523	0	1.0
NZ_AP018205_2	2.19|53560|42|NZ_AP018205|CRISPRCasFinder,CRT	53560-53601	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	451825-451866	0	1.0
NZ_AP018205_2	2.19|53560|42|NZ_AP018205|CRISPRCasFinder,CRT	53560-53601	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53560-53601	0	1.0
NZ_AP018205_2	2.20|52152|46|NZ_AP018205|PILER-CR	52152-52197	46	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453231-453276	0	1.0
NZ_AP018205_2	2.20|52152|46|NZ_AP018205|PILER-CR	52152-52197	46	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52150-52195	0	1.0
NZ_AP018205_2	2.21|52234|39|NZ_AP018205|PILER-CR	52234-52272	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52232-52270	0	1.0
NZ_AP018205_2	2.21|52234|39|NZ_AP018205|PILER-CR	52234-52272	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453156-453194	0	1.0
NZ_AP018205_2	2.22|52309|41|NZ_AP018205|PILER-CR	52309-52349	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	453079-453119	0	1.0
NZ_AP018205_2	2.22|52309|41|NZ_AP018205|PILER-CR	52309-52349	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52307-52347	0	1.0
NZ_AP018205_2	2.23|52386|52|NZ_AP018205|PILER-CR	52386-52437	52	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52384-52435	0	1.0
NZ_AP018205_2	2.23|52386|52|NZ_AP018205|PILER-CR	52386-52437	52	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452991-453042	0	1.0
NZ_AP018205_2	2.24|52474|39|NZ_AP018205|PILER-CR	52474-52512	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52472-52510	0	1.0
NZ_AP018205_2	2.24|52474|39|NZ_AP018205|PILER-CR	52474-52512	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452916-452954	0	1.0
NZ_AP018205_2	2.25|52549|43|NZ_AP018205|PILER-CR	52549-52591	43	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452837-452879	0	1.0
NZ_AP018205_2	2.25|52549|43|NZ_AP018205|PILER-CR	52549-52591	43	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52547-52589	0	1.0
NZ_AP018205_2	2.26|52628|46|NZ_AP018205|PILER-CR	52628-52673	46	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52626-52671	0	1.0
NZ_AP018205_2	2.26|52628|46|NZ_AP018205|PILER-CR	52628-52673	46	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452755-452800	0	1.0
NZ_AP018205_2	2.27|52710|40|NZ_AP018205|PILER-CR	52710-52749	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452679-452718	0	1.0
NZ_AP018205_2	2.27|52710|40|NZ_AP018205|PILER-CR	52710-52749	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52708-52747	0	1.0
NZ_AP018205_2	2.28|52786|46|NZ_AP018205|PILER-CR	52786-52831	46	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452597-452642	0	1.0
NZ_AP018205_2	2.28|52786|46|NZ_AP018205|PILER-CR	52786-52831	46	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52784-52829	0	1.0
NZ_AP018205_2	2.29|52868|41|NZ_AP018205|PILER-CR	52868-52908	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452520-452560	0	1.0
NZ_AP018205_2	2.29|52868|41|NZ_AP018205|PILER-CR	52868-52908	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52866-52906	0	1.0
NZ_AP018205_2	2.30|52945|49|NZ_AP018205|PILER-CR	52945-52993	49	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452435-452483	0	1.0
NZ_AP018205_2	2.30|52945|49|NZ_AP018205|PILER-CR	52945-52993	49	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	52943-52991	0	1.0
NZ_AP018205_2	2.31|53030|41|NZ_AP018205|PILER-CR	53030-53070	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53028-53068	0	1.0
NZ_AP018205_2	2.31|53030|41|NZ_AP018205|PILER-CR	53030-53070	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452358-452398	0	1.0
NZ_AP018205_2	2.32|53107|40|NZ_AP018205|PILER-CR	53107-53146	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452282-452321	0	1.0
NZ_AP018205_2	2.32|53107|40|NZ_AP018205|PILER-CR	53107-53146	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53105-53144	0	1.0
NZ_AP018205_2	2.33|53183|41|NZ_AP018205|PILER-CR	53183-53223	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452205-452245	0	1.0
NZ_AP018205_2	2.33|53183|41|NZ_AP018205|PILER-CR	53183-53223	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53181-53221	0	1.0
NZ_AP018205_2	2.34|53260|41|NZ_AP018205|PILER-CR	53260-53300	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452128-452168	0	1.0
NZ_AP018205_2	2.34|53260|41|NZ_AP018205|PILER-CR	53260-53300	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53258-53298	0	1.0
NZ_AP018205_2	2.35|53337|38|NZ_AP018205|PILER-CR	53337-53374	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53335-53372	0	1.0
NZ_AP018205_2	2.35|53337|38|NZ_AP018205|PILER-CR	53337-53374	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	452054-452091	0	1.0
NZ_AP018205_2	2.36|53411|41|NZ_AP018205|PILER-CR	53411-53451	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53409-53449	0	1.0
NZ_AP018205_2	2.36|53411|41|NZ_AP018205|PILER-CR	53411-53451	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	451977-452017	0	1.0
NZ_AP018205_2	2.37|53488|38|NZ_AP018205|PILER-CR	53488-53525	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	451903-451940	0	1.0
NZ_AP018205_2	2.37|53488|38|NZ_AP018205|PILER-CR	53488-53525	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53486-53523	0	1.0
NZ_AP018205_2	2.38|53562|42|NZ_AP018205|PILER-CR	53562-53603	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	451825-451866	0	1.0
NZ_AP018205_2	2.38|53562|42|NZ_AP018205|PILER-CR	53562-53603	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	53560-53601	0	1.0
NZ_AP018205_3	3.1|55795|41|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55795-55835	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449591-449631	0	1.0
NZ_AP018205_3	3.1|55795|41|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55795-55835	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	55795-55835	0	1.0
NZ_AP018205_3	3.2|55872|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55872-55910	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449516-449554	0	1.0
NZ_AP018205_3	3.2|55872|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55872-55910	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	55872-55910	0	1.0
NZ_AP018205_3	3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55947-55981	35	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449445-449479	0	1.0
NZ_AP018205_3	3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55947-55981	35	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	55947-55981	0	1.0
NZ_AP018205_3	3.4|56018|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56018-56056	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56018-56056	0	1.0
NZ_AP018205_3	3.4|56018|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56018-56056	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449370-449408	0	1.0
NZ_AP018205_3	3.5|56093|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56093-56132	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56093-56132	0	1.0
NZ_AP018205_3	3.5|56093|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56093-56132	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449294-449333	0	1.0
NZ_AP018205_3	3.6|56169|48|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56169-56216	48	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449210-449257	0	1.0
NZ_AP018205_3	3.6|56169|48|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56169-56216	48	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56169-56216	0	1.0
NZ_AP018205_3	3.7|56253|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56253-56288	36	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56253-56288	0	1.0
NZ_AP018205_3	3.7|56253|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56253-56288	36	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449138-449173	0	1.0
NZ_AP018205_3	3.8|56325|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56325-56366	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	449060-449101	0	1.0
NZ_AP018205_3	3.8|56325|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56325-56366	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56325-56366	0	1.0
NZ_AP018205_3	3.9|56403|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56403-56441	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448985-449023	0	1.0
NZ_AP018205_3	3.9|56403|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56403-56441	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56403-56441	0	1.0
NZ_AP018205_3	3.10|56478|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56478-56516	39	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56478-56516	0	1.0
NZ_AP018205_3	3.10|56478|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56478-56516	39	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448910-448948	0	1.0
NZ_AP018205_3	3.11|56553|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56553-56594	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448832-448873	0	1.0
NZ_AP018205_3	3.11|56553|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56553-56594	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56553-56594	0	1.0
NZ_AP018205_3	3.12|56631|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56631-56665	35	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448761-448795	0	1.0
NZ_AP018205_3	3.12|56631|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56631-56665	35	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56631-56665	0	1.0
NZ_AP018205_3	3.13|56702|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56702-56741	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448685-448724	0	1.0
NZ_AP018205_3	3.13|56702|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56702-56741	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56702-56741	0	1.0
NZ_AP018205_3	3.14|56778|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56778-56814	37	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448612-448648	0	1.0
NZ_AP018205_3	3.14|56778|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56778-56814	37	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56778-56814	0	1.0
NZ_AP018205_3	3.15|56851|45|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56851-56895	45	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56851-56895	0	1.0
NZ_AP018205_3	3.15|56851|45|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56851-56895	45	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448531-448575	0	1.0
NZ_AP018205_3	3.16|56932|34|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56932-56965	34	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448461-448494	0	1.0
NZ_AP018205_3	3.16|56932|34|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	56932-56965	34	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	56932-56965	0	1.0
NZ_AP018205_3	3.17|57002|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	57002-57037	36	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57002-57037	0	1.0
NZ_AP018205_3	3.17|57002|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	57002-57037	36	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448389-448424	0	1.0
NZ_AP018205_3	3.18|57074|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	57074-57110	37	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57074-57110	0	1.0
NZ_AP018205_3	3.18|57074|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	57074-57110	37	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448316-448352	0	1.0
NZ_AP018205_3	3.19|57147|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	57147-57182	36	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448244-448279	0	1.0
NZ_AP018205_3	3.19|57147|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	57147-57182	36	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57147-57182	0	1.0
NZ_AP018205_3	3.20|57219|36|NZ_AP018205|CRISPRCasFinder,CRT	57219-57254	36	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57219-57254	0	1.0
NZ_AP018205_3	3.20|57219|36|NZ_AP018205|CRISPRCasFinder,CRT	57219-57254	36	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448172-448207	0	1.0
NZ_AP018205_3	3.21|57291|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57291-57338	48	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448088-448135	0	1.0
NZ_AP018205_3	3.21|57291|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57291-57338	48	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57291-57338	0	1.0
NZ_AP018205_3	3.22|57375|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57375-57416	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	448010-448051	0	1.0
NZ_AP018205_3	3.22|57375|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57375-57416	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57375-57416	0	1.0
NZ_AP018205_3	3.23|57453|45|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57453-57497	45	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447929-447973	0	1.0
NZ_AP018205_3	3.23|57453|45|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57453-57497	45	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57453-57497	0	1.0
NZ_AP018205_3	3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57534-57571	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447855-447892	0	1.0
NZ_AP018205_3	3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57534-57571	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57534-57571	0	1.0
NZ_AP018205_3	3.25|57608|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57608-57647	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57608-57647	0	1.0
NZ_AP018205_3	3.25|57608|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57608-57647	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447779-447818	0	1.0
NZ_AP018205_3	3.26|57684|52|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57684-57735	52	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447691-447742	0	1.0
NZ_AP018205_3	3.26|57684|52|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57684-57735	52	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57684-57735	0	1.0
NZ_AP018205_3	3.27|57772|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57772-57815	44	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447611-447654	0	1.0
NZ_AP018205_3	3.27|57772|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57772-57815	44	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57772-57815	0	1.0
NZ_AP018205_3	3.28|57852|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57852-57891	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447535-447574	0	1.0
NZ_AP018205_3	3.28|57852|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57852-57891	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57852-57891	0	1.0
NZ_AP018205_3	3.29|57928|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57928-57967	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	57928-57967	0	1.0
NZ_AP018205_3	3.29|57928|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57928-57967	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447459-447498	0	1.0
NZ_AP018205_3	3.30|58004|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58004-58041	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447385-447422	0	1.0
NZ_AP018205_3	3.30|58004|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58004-58041	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58004-58041	0	1.0
NZ_AP018205_3	3.31|58078|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58078-58119	42	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58078-58119	0	1.0
NZ_AP018205_3	3.31|58078|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58078-58119	42	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447307-447348	0	1.0
NZ_AP018205_3	3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58156-58198	43	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58156-58198	0	1.0
NZ_AP018205_3	3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58156-58198	43	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447228-447270	0	1.0
NZ_AP018205_3	3.33|58235|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58235-58277	43	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58235-58277	0	1.0
NZ_AP018205_3	3.33|58235|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58235-58277	43	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447149-447191	0	1.0
NZ_AP018205_3	3.34|58314|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58314-58353	40	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	447073-447112	0	1.0
NZ_AP018205_3	3.34|58314|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58314-58353	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58314-58353	0	1.0
NZ_AP018205_3	3.35|58390|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58390-58432	43	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446994-447036	0	1.0
NZ_AP018205_3	3.35|58390|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58390-58432	43	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58390-58432	0	1.0
NZ_AP018205_3	3.36|58469|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58469-58512	44	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446914-446957	0	1.0
NZ_AP018205_3	3.36|58469|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58469-58512	44	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58469-58512	0	1.0
NZ_AP018205_3	3.37|58549|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58549-58585	37	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446841-446877	0	1.0
NZ_AP018205_3	3.37|58549|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58549-58585	37	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58549-58585	0	1.0
NZ_AP018205_3	3.38|58622|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58622-58669	48	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58622-58669	0	1.0
NZ_AP018205_3	3.38|58622|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58622-58669	48	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446757-446804	0	1.0
NZ_AP018205_3	3.39|58706|41|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58706-58746	41	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58706-58746	0	1.0
NZ_AP018205_3	3.39|58706|41|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58706-58746	41	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446680-446720	0	1.0
NZ_AP018205_3	3.40|58783|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58783-58820	38	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58783-58820	0	1.0
NZ_AP018205_3	3.40|58783|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58783-58820	38	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446606-446643	0	1.0
NZ_AP018205_3	3.41|58857|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58857-58893	37	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	446533-446569	0	1.0
NZ_AP018205_3	3.41|58857|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58857-58893	37	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58857-58893	0	1.0
NZ_AP018205_3	3.42|58930|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	58930-58969	40	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	58930-58969	0	1.0
NZ_AP018205_4	4.1|138871|54|NZ_AP018205|CRISPRCasFinder	138871-138924	54	NZ_AP018205	Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome	138871-138924	0	1.0
NZ_AP018205_4	4.1|138871|54|NZ_AP018205|CRISPRCasFinder	138871-138924	54	NZ_AP014640	Leptolyngbya boryana IAM M-101 plasmid pLBX	366578-366631	0	1.0
NZ_AP018205_3	3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57534-57571	38	NC_008367	Phormidium phage Pf-WMP4, complete genome	40829-40866	1	0.974
NZ_AP018205_3	3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57534-57571	38	DQ875742	Cyanophage Pf-WMP4, complete genome	40829-40866	1	0.974
NZ_AP018205_3	3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57534-57571	38	NC_008367	Phormidium phage Pf-WMP4, complete genome	1-35	4	0.895
NZ_AP018205_3	3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR	57534-57571	38	DQ875742	Cyanophage Pf-WMP4, complete genome	1-35	4	0.895
NZ_AP018205_1	1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder	51640-51672	33	MF141539	Mycobacterium phage MyraDee, complete genome	4486-4518	8	0.758
NZ_AP018205_1	1.10|51641|33|NZ_AP018205|PILER-CR	51641-51673	33	MF141539	Mycobacterium phage MyraDee, complete genome	4486-4518	8	0.758
NZ_AP018205_3	3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55947-55981	35	MN692960	Marine virus AFVG_117M7, complete genome	34102-34136	8	0.771
NZ_AP018205_3	3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55947-55981	35	MN692988	Marine virus AFVG_117M76, complete genome	4825-4859	8	0.771
NZ_AP018205_3	3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT	55947-55981	35	MN692984	Marine virus AFVG_117M10, complete genome	3359-3393	8	0.771

1. spacer 1.1|51346|42|NZ_AP018205|CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gatatcgcggatccactgatggatatcattgagggcactgcg	CRISPR spacer
gatatcgcggatccactgatggatatcattgagggcactgcg	Protospacer
******************************************

2. spacer 1.1|51346|42|NZ_AP018205|CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gatatcgcggatccactgatggatatcattgagggcactgcg	CRISPR spacer
gatatcgcggatccactgatggatatcattgagggcactgcg	Protospacer
******************************************

3. spacer 1.2|51424|37|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cattaccgaccctaattcgggagaaggaatcaacatc	CRISPR spacer
cattaccgaccctaattcgggagaaggaatcaacatc	Protospacer
*************************************

4. spacer 1.2|51424|37|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cattaccgaccctaattcgggagaaggaatcaacatc	CRISPR spacer
cattaccgaccctaattcgggagaaggaatcaacatc	Protospacer
*************************************

5. spacer 1.3|51497|36|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tcgaacctataaccctgctaatggaaaatggcgtat	CRISPR spacer
tcgaacctataaccctgctaatggaaaatggcgtat	Protospacer
************************************

6. spacer 1.3|51497|36|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tcgaacctataaccctgctaatggaaaatggcgtat	CRISPR spacer
tcgaacctataaccctgctaatggaaaatggcgtat	Protospacer
************************************

7. spacer 1.4|51569|35|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aagtgcatttggcttgcctattaaaggtgcaatga	CRISPR spacer
aagtgcatttggcttgcctattaaaggtgcaatga	Protospacer
***********************************

8. spacer 1.4|51569|35|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aagtgcatttggcttgcctattaaaggtgcaatga	CRISPR spacer
aagtgcatttggcttgcctattaaaggtgcaatga	Protospacer
***********************************

9. spacer 1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgatgcaatcgcgaccgtggcgcaactggaag	CRISPR spacer
ttgatgcaatcgcgaccgtggcgcaactggaag	Protospacer
*********************************

10. spacer 1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgatgcaatcgcgaccgtggcgcaactggaag	CRISPR spacer
ttgatgcaatcgcgaccgtggcgcaactggaag	Protospacer
*********************************

11. spacer 1.6|51347|42|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gatatcgcggatccactgatggatatcattgagggcactgcg	CRISPR spacer
gatatcgcggatccactgatggatatcattgagggcactgcg	Protospacer
******************************************

12. spacer 1.6|51347|42|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gatatcgcggatccactgatggatatcattgagggcactgcg	CRISPR spacer
gatatcgcggatccactgatggatatcattgagggcactgcg	Protospacer
******************************************

13. spacer 1.7|51425|37|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cattaccgaccctaattcgggagaaggaatcaacatc	CRISPR spacer
cattaccgaccctaattcgggagaaggaatcaacatc	Protospacer
*************************************

14. spacer 1.7|51425|37|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cattaccgaccctaattcgggagaaggaatcaacatc	CRISPR spacer
cattaccgaccctaattcgggagaaggaatcaacatc	Protospacer
*************************************

15. spacer 1.8|51498|36|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tcgaacctataaccctgctaatggaaaatggcgtat	CRISPR spacer
tcgaacctataaccctgctaatggaaaatggcgtat	Protospacer
************************************

16. spacer 1.8|51498|36|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tcgaacctataaccctgctaatggaaaatggcgtat	CRISPR spacer
tcgaacctataaccctgctaatggaaaatggcgtat	Protospacer
************************************

17. spacer 1.9|51570|35|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aagtgcatttggcttgcctattaaaggtgcaatga	CRISPR spacer
aagtgcatttggcttgcctattaaaggtgcaatga	Protospacer
***********************************

18. spacer 1.9|51570|35|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aagtgcatttggcttgcctattaaaggtgcaatga	CRISPR spacer
aagtgcatttggcttgcctattaaaggtgcaatga	Protospacer
***********************************

19. spacer 1.10|51641|33|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgatgcaatcgcgaccgtggcgcaactggaag	CRISPR spacer
ttgatgcaatcgcgaccgtggcgcaactggaag	Protospacer
*********************************

20. spacer 1.10|51641|33|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgatgcaatcgcgaccgtggcgcaactggaag	CRISPR spacer
ttgatgcaatcgcgaccgtggcgcaactggaag	Protospacer
*********************************

21. spacer 2.1|52150|46|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	CRISPR spacer
ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	Protospacer
**********************************************

22. spacer 2.1|52150|46|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	CRISPR spacer
ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	Protospacer
**********************************************

23. spacer 2.2|52232|39|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aatttcgtaatcatccgacgattcgacgcacgatcgatg	CRISPR spacer
aatttcgtaatcatccgacgattcgacgcacgatcgatg	Protospacer
***************************************

24. spacer 2.2|52232|39|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aatttcgtaatcatccgacgattcgacgcacgatcgatg	CRISPR spacer
aatttcgtaatcatccgacgattcgacgcacgatcgatg	Protospacer
***************************************

25. spacer 2.3|52307|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aacagaaatcttggcggacttgatgacttgtttgggtaggg	CRISPR spacer
aacagaaatcttggcggacttgatgacttgtttgggtaggg	Protospacer
*****************************************

26. spacer 2.3|52307|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aacagaaatcttggcggacttgatgacttgtttgggtaggg	CRISPR spacer
aacagaaatcttggcggacttgatgacttgtttgggtaggg	Protospacer
*****************************************

27. spacer 2.4|52384|52|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	CRISPR spacer
ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	Protospacer
****************************************************

28. spacer 2.4|52384|52|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	CRISPR spacer
ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	Protospacer
****************************************************

29. spacer 2.5|52472|39|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgagcaacgattagaagccacccggatgttgattgaag	CRISPR spacer
ttgagcaacgattagaagccacccggatgttgattgaag	Protospacer
***************************************

30. spacer 2.5|52472|39|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgagcaacgattagaagccacccggatgttgattgaag	CRISPR spacer
ttgagcaacgattagaagccacccggatgttgattgaag	Protospacer
***************************************

31. spacer 2.6|52547|43|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	CRISPR spacer
cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	Protospacer
*******************************************

32. spacer 2.6|52547|43|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	CRISPR spacer
cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	Protospacer
*******************************************

33. spacer 2.7|52626|46|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	CRISPR spacer
ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	Protospacer
**********************************************

34. spacer 2.7|52626|46|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	CRISPR spacer
ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	Protospacer
**********************************************

35. spacer 2.8|52708|40|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gtaccacaagaaaaacgctagagatccatgtatacagcaa	CRISPR spacer
gtaccacaagaaaaacgctagagatccatgtatacagcaa	Protospacer
****************************************

36. spacer 2.8|52708|40|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gtaccacaagaaaaacgctagagatccatgtatacagcaa	CRISPR spacer
gtaccacaagaaaaacgctagagatccatgtatacagcaa	Protospacer
****************************************

37. spacer 2.9|52784|46|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	CRISPR spacer
tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	Protospacer
**********************************************

38. spacer 2.9|52784|46|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	CRISPR spacer
tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	Protospacer
**********************************************

39. spacer 2.10|52866|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gcgtattatgagggattgacagagaagaggggcgatcgtgt	CRISPR spacer
gcgtattatgagggattgacagagaagaggggcgatcgtgt	Protospacer
*****************************************

40. spacer 2.10|52866|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gcgtattatgagggattgacagagaagaggggcgatcgtgt	CRISPR spacer
gcgtattatgagggattgacagagaagaggggcgatcgtgt	Protospacer
*****************************************

41. spacer 2.11|52943|49|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	CRISPR spacer
ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	Protospacer
*************************************************

42. spacer 2.11|52943|49|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	CRISPR spacer
ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	Protospacer
*************************************************

43. spacer 2.12|53028|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

caccgtatgttgctgctggcgcagcttaccccccaaattat	CRISPR spacer
caccgtatgttgctgctggcgcagcttaccccccaaattat	Protospacer
*****************************************

44. spacer 2.12|53028|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

caccgtatgttgctgctggcgcagcttaccccccaaattat	CRISPR spacer
caccgtatgttgctgctggcgcagcttaccccccaaattat	Protospacer
*****************************************

45. spacer 2.13|53105|40|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gtggagagaatatcttggtgcgtatggtatcaaccctgac	CRISPR spacer
gtggagagaatatcttggtgcgtatggtatcaaccctgac	Protospacer
****************************************

46. spacer 2.13|53105|40|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gtggagagaatatcttggtgcgtatggtatcaaccctgac	CRISPR spacer
gtggagagaatatcttggtgcgtatggtatcaaccctgac	Protospacer
****************************************

47. spacer 2.14|53181|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

agccagtgaaattggagttgtttggctgggattaatcccgg	CRISPR spacer
agccagtgaaattggagttgtttggctgggattaatcccgg	Protospacer
*****************************************

48. spacer 2.14|53181|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

agccagtgaaattggagttgtttggctgggattaatcccgg	CRISPR spacer
agccagtgaaattggagttgtttggctgggattaatcccgg	Protospacer
*****************************************

49. spacer 2.15|53258|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttaggtaataaatatcagctttcttttgtgggtgatcttat	CRISPR spacer
ttaggtaataaatatcagctttcttttgtgggtgatcttat	Protospacer
*****************************************

50. spacer 2.15|53258|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttaggtaataaatatcagctttcttttgtgggtgatcttat	CRISPR spacer
ttaggtaataaatatcagctttcttttgtgggtgatcttat	Protospacer
*****************************************

51. spacer 2.16|53335|38|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aacccttcgaacctgttccttctactttagaagaaatg	CRISPR spacer
aacccttcgaacctgttccttctactttagaagaaatg	Protospacer
**************************************

52. spacer 2.16|53335|38|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aacccttcgaacctgttccttctactttagaagaaatg	CRISPR spacer
aacccttcgaacctgttccttctactttagaagaaatg	Protospacer
**************************************

53. spacer 2.17|53409|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aagctaataagcattatcacgataatgcaaatccaaacctt	CRISPR spacer
aagctaataagcattatcacgataatgcaaatccaaacctt	Protospacer
*****************************************

54. spacer 2.17|53409|41|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aagctaataagcattatcacgataatgcaaatccaaacctt	CRISPR spacer
aagctaataagcattatcacgataatgcaaatccaaacctt	Protospacer
*****************************************

55. spacer 2.18|53486|38|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

actgtagaaggaattcaatgggctggtaaagtatgctc	CRISPR spacer
actgtagaaggaattcaatgggctggtaaagtatgctc	Protospacer
**************************************

56. spacer 2.18|53486|38|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

actgtagaaggaattcaatgggctggtaaagtatgctc	CRISPR spacer
actgtagaaggaattcaatgggctggtaaagtatgctc	Protospacer
**************************************

57. spacer 2.19|53560|42|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gaagctgagcttaatgctttctttactaaagaagcgactctt	CRISPR spacer
gaagctgagcttaatgctttctttactaaagaagcgactctt	Protospacer
******************************************

58. spacer 2.19|53560|42|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gaagctgagcttaatgctttctttactaaagaagcgactctt	CRISPR spacer
gaagctgagcttaatgctttctttactaaagaagcgactctt	Protospacer
******************************************

59. spacer 2.20|52152|46|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	CRISPR spacer
ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	Protospacer
**********************************************

60. spacer 2.20|52152|46|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	CRISPR spacer
ctgagtcaagaggctaggaaagttgcttcaagaattatggtcgagt	Protospacer
**********************************************

61. spacer 2.21|52234|39|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aatttcgtaatcatccgacgattcgacgcacgatcgatg	CRISPR spacer
aatttcgtaatcatccgacgattcgacgcacgatcgatg	Protospacer
***************************************

62. spacer 2.21|52234|39|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aatttcgtaatcatccgacgattcgacgcacgatcgatg	CRISPR spacer
aatttcgtaatcatccgacgattcgacgcacgatcgatg	Protospacer
***************************************

63. spacer 2.22|52309|41|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aacagaaatcttggcggacttgatgacttgtttgggtaggg	CRISPR spacer
aacagaaatcttggcggacttgatgacttgtttgggtaggg	Protospacer
*****************************************

64. spacer 2.22|52309|41|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aacagaaatcttggcggacttgatgacttgtttgggtaggg	CRISPR spacer
aacagaaatcttggcggacttgatgacttgtttgggtaggg	Protospacer
*****************************************

65. spacer 2.23|52386|52|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	CRISPR spacer
ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	Protospacer
****************************************************

66. spacer 2.23|52386|52|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	CRISPR spacer
ttgcaattggacagctcatcaaaaatctcagtttattcagcaaattattcaa	Protospacer
****************************************************

67. spacer 2.24|52474|39|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgagcaacgattagaagccacccggatgttgattgaag	CRISPR spacer
ttgagcaacgattagaagccacccggatgttgattgaag	Protospacer
***************************************

68. spacer 2.24|52474|39|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgagcaacgattagaagccacccggatgttgattgaag	CRISPR spacer
ttgagcaacgattagaagccacccggatgttgattgaag	Protospacer
***************************************

69. spacer 2.25|52549|43|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	CRISPR spacer
cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	Protospacer
*******************************************

70. spacer 2.25|52549|43|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	CRISPR spacer
cggaagacatccaacatcttacgctcatgcgtaaccagttaaa	Protospacer
*******************************************

71. spacer 2.26|52628|46|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	CRISPR spacer
ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	Protospacer
**********************************************

72. spacer 2.26|52628|46|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	CRISPR spacer
ccactgcgatcactacgggattgtccccggaggtaagtgtctgtgc	Protospacer
**********************************************

73. spacer 2.27|52710|40|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gtaccacaagaaaaacgctagagatccatgtatacagcaa	CRISPR spacer
gtaccacaagaaaaacgctagagatccatgtatacagcaa	Protospacer
****************************************

74. spacer 2.27|52710|40|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gtaccacaagaaaaacgctagagatccatgtatacagcaa	CRISPR spacer
gtaccacaagaaaaacgctagagatccatgtatacagcaa	Protospacer
****************************************

75. spacer 2.28|52786|46|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	CRISPR spacer
tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	Protospacer
**********************************************

76. spacer 2.28|52786|46|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	CRISPR spacer
tcagaaatcgaagctttgattggctcctctcgtaaagaggtggaaa	Protospacer
**********************************************

77. spacer 2.29|52868|41|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gcgtattatgagggattgacagagaagaggggcgatcgtgt	CRISPR spacer
gcgtattatgagggattgacagagaagaggggcgatcgtgt	Protospacer
*****************************************

78. spacer 2.29|52868|41|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gcgtattatgagggattgacagagaagaggggcgatcgtgt	CRISPR spacer
gcgtattatgagggattgacagagaagaggggcgatcgtgt	Protospacer
*****************************************

79. spacer 2.30|52945|49|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	CRISPR spacer
ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	Protospacer
*************************************************

80. spacer 2.30|52945|49|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	CRISPR spacer
ctcacattttgagcagcttccttatatttctcaacaggaatacaagtga	Protospacer
*************************************************

81. spacer 2.31|53030|41|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

caccgtatgttgctgctggcgcagcttaccccccaaattat	CRISPR spacer
caccgtatgttgctgctggcgcagcttaccccccaaattat	Protospacer
*****************************************

82. spacer 2.31|53030|41|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

caccgtatgttgctgctggcgcagcttaccccccaaattat	CRISPR spacer
caccgtatgttgctgctggcgcagcttaccccccaaattat	Protospacer
*****************************************

83. spacer 2.32|53107|40|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gtggagagaatatcttggtgcgtatggtatcaaccctgac	CRISPR spacer
gtggagagaatatcttggtgcgtatggtatcaaccctgac	Protospacer
****************************************

84. spacer 2.32|53107|40|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gtggagagaatatcttggtgcgtatggtatcaaccctgac	CRISPR spacer
gtggagagaatatcttggtgcgtatggtatcaaccctgac	Protospacer
****************************************

85. spacer 2.33|53183|41|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

agccagtgaaattggagttgtttggctgggattaatcccgg	CRISPR spacer
agccagtgaaattggagttgtttggctgggattaatcccgg	Protospacer
*****************************************

86. spacer 2.33|53183|41|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

agccagtgaaattggagttgtttggctgggattaatcccgg	CRISPR spacer
agccagtgaaattggagttgtttggctgggattaatcccgg	Protospacer
*****************************************

87. spacer 2.34|53260|41|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttaggtaataaatatcagctttcttttgtgggtgatcttat	CRISPR spacer
ttaggtaataaatatcagctttcttttgtgggtgatcttat	Protospacer
*****************************************

88. spacer 2.34|53260|41|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttaggtaataaatatcagctttcttttgtgggtgatcttat	CRISPR spacer
ttaggtaataaatatcagctttcttttgtgggtgatcttat	Protospacer
*****************************************

89. spacer 2.35|53337|38|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aacccttcgaacctgttccttctactttagaagaaatg	CRISPR spacer
aacccttcgaacctgttccttctactttagaagaaatg	Protospacer
**************************************

90. spacer 2.35|53337|38|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aacccttcgaacctgttccttctactttagaagaaatg	CRISPR spacer
aacccttcgaacctgttccttctactttagaagaaatg	Protospacer
**************************************

91. spacer 2.36|53411|41|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aagctaataagcattatcacgataatgcaaatccaaacctt	CRISPR spacer
aagctaataagcattatcacgataatgcaaatccaaacctt	Protospacer
*****************************************

92. spacer 2.36|53411|41|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aagctaataagcattatcacgataatgcaaatccaaacctt	CRISPR spacer
aagctaataagcattatcacgataatgcaaatccaaacctt	Protospacer
*****************************************

93. spacer 2.37|53488|38|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

actgtagaaggaattcaatgggctggtaaagtatgctc	CRISPR spacer
actgtagaaggaattcaatgggctggtaaagtatgctc	Protospacer
**************************************

94. spacer 2.37|53488|38|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

actgtagaaggaattcaatgggctggtaaagtatgctc	CRISPR spacer
actgtagaaggaattcaatgggctggtaaagtatgctc	Protospacer
**************************************

95. spacer 2.38|53562|42|NZ_AP018205|PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gaagctgagcttaatgctttctttactaaagaagcgactctt	CRISPR spacer
gaagctgagcttaatgctttctttactaaagaagcgactctt	Protospacer
******************************************

96. spacer 2.38|53562|42|NZ_AP018205|PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gaagctgagcttaatgctttctttactaaagaagcgactctt	CRISPR spacer
gaagctgagcttaatgctttctttactaaagaagcgactctt	Protospacer
******************************************

97. spacer 3.1|55795|41|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tcttatgaccatcgaaaggcagaattacatcaattcgattc	CRISPR spacer
tcttatgaccatcgaaaggcagaattacatcaattcgattc	Protospacer
*****************************************

98. spacer 3.1|55795|41|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tcttatgaccatcgaaaggcagaattacatcaattcgattc	CRISPR spacer
tcttatgaccatcgaaaggcagaattacatcaattcgattc	Protospacer
*****************************************

99. spacer 3.2|55872|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

caacattgaacaggatgcagacacaatcctgtttatcta	CRISPR spacer
caacattgaacaggatgcagacacaatcctgtttatcta	Protospacer
***************************************

100. spacer 3.2|55872|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

caacattgaacaggatgcagacacaatcctgtttatcta	CRISPR spacer
caacattgaacaggatgcagacacaatcctgtttatcta	Protospacer
***************************************

101. spacer 3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

atcaaagaaattagatcaagctagaaaagatacag	CRISPR spacer
atcaaagaaattagatcaagctagaaaagatacag	Protospacer
***********************************

102. spacer 3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

atcaaagaaattagatcaagctagaaaagatacag	CRISPR spacer
atcaaagaaattagatcaagctagaaaagatacag	Protospacer
***********************************

103. spacer 3.4|56018|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gcatcaattttattggctctggtaatagcaatgatcgtg	CRISPR spacer
gcatcaattttattggctctggtaatagcaatgatcgtg	Protospacer
***************************************

104. spacer 3.4|56018|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gcatcaattttattggctctggtaatagcaatgatcgtg	CRISPR spacer
gcatcaattttattggctctggtaatagcaatgatcgtg	Protospacer
***************************************

105. spacer 3.5|56093|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tgtagctttactttcagagcatccattatttaatatttca	CRISPR spacer
tgtagctttactttcagagcatccattatttaatatttca	Protospacer
****************************************

106. spacer 3.5|56093|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tgtagctttactttcagagcatccattatttaatatttca	CRISPR spacer
tgtagctttactttcagagcatccattatttaatatttca	Protospacer
****************************************

107. spacer 3.6|56169|48|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tggaggtagatattaaatgccagtaattaacaataatgtacttctaga	CRISPR spacer
tggaggtagatattaaatgccagtaattaacaataatgtacttctaga	Protospacer
************************************************

108. spacer 3.6|56169|48|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tggaggtagatattaaatgccagtaattaacaataatgtacttctaga	CRISPR spacer
tggaggtagatattaaatgccagtaattaacaataatgtacttctaga	Protospacer
************************************************

109. spacer 3.7|56253|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctcgtatggtggagcgtttgactactaccttcttag	CRISPR spacer
ctcgtatggtggagcgtttgactactaccttcttag	Protospacer
************************************

110. spacer 3.7|56253|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctcgtatggtggagcgtttgactactaccttcttag	CRISPR spacer
ctcgtatggtggagcgtttgactactaccttcttag	Protospacer
************************************

111. spacer 3.8|56325|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctcagatcttaattcagattcttgatcttagattcagatcta	CRISPR spacer
ctcagatcttaattcagattcttgatcttagattcagatcta	Protospacer
******************************************

112. spacer 3.8|56325|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctcagatcttaattcagattcttgatcttagattcagatcta	CRISPR spacer
ctcagatcttaattcagattcttgatcttagattcagatcta	Protospacer
******************************************

113. spacer 3.9|56403|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

actcacggcaccgaagatcaacttcgagcaatacaagta	CRISPR spacer
actcacggcaccgaagatcaacttcgagcaatacaagta	Protospacer
***************************************

114. spacer 3.9|56403|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

actcacggcaccgaagatcaacttcgagcaatacaagta	CRISPR spacer
actcacggcaccgaagatcaacttcgagcaatacaagta	Protospacer
***************************************

115. spacer 3.10|56478|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

attcgctctgcgtttgtgtccagtgagcaatttgcgcgg	CRISPR spacer
attcgctctgcgtttgtgtccagtgagcaatttgcgcgg	Protospacer
***************************************

116. spacer 3.10|56478|39|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

attcgctctgcgtttgtgtccagtgagcaatttgcgcgg	CRISPR spacer
attcgctctgcgtttgtgtccagtgagcaatttgcgcgg	Protospacer
***************************************

117. spacer 3.11|56553|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgtgatgcaatcttggcactcataatctgcacatctttcat	CRISPR spacer
ttgtgatgcaatcttggcactcataatctgcacatctttcat	Protospacer
******************************************

118. spacer 3.11|56553|42|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgtgatgcaatcttggcactcataatctgcacatctttcat	CRISPR spacer
ttgtgatgcaatcttggcactcataatctgcacatctttcat	Protospacer
******************************************

119. spacer 3.12|56631|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

actaaaacaattagattttgcgttctgttcttgga	CRISPR spacer
actaaaacaattagattttgcgttctgttcttgga	Protospacer
***********************************

120. spacer 3.12|56631|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

actaaaacaattagattttgcgttctgttcttgga	CRISPR spacer
actaaaacaattagattttgcgttctgttcttgga	Protospacer
***********************************

121. spacer 3.13|56702|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctccccacgtttgaggctaagacatgtgtgctgtgctggc	CRISPR spacer
ctccccacgtttgaggctaagacatgtgtgctgtgctggc	Protospacer
****************************************

122. spacer 3.13|56702|40|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctccccacgtttgaggctaagacatgtgtgctgtgctggc	CRISPR spacer
ctccccacgtttgaggctaagacatgtgtgctgtgctggc	Protospacer
****************************************

123. spacer 3.14|56778|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tgaaagactaattagtattgctgctgatacaaatttg	CRISPR spacer
tgaaagactaattagtattgctgctgatacaaatttg	Protospacer
*************************************

124. spacer 3.14|56778|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tgaaagactaattagtattgctgctgatacaaatttg	CRISPR spacer
tgaaagactaattagtattgctgctgatacaaatttg	Protospacer
*************************************

125. spacer 3.15|56851|45|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cagataagcctttatcacccaatctattcgataaaaacccataaa	CRISPR spacer
cagataagcctttatcacccaatctattcgataaaaacccataaa	Protospacer
*********************************************

126. spacer 3.15|56851|45|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cagataagcctttatcacccaatctattcgataaaaacccataaa	CRISPR spacer
cagataagcctttatcacccaatctattcgataaaaacccataaa	Protospacer
*********************************************

127. spacer 3.16|56932|34|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cgggtacaccttctattggatacaagcttgtgat	CRISPR spacer
cgggtacaccttctattggatacaagcttgtgat	Protospacer
**********************************

128. spacer 3.16|56932|34|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cgggtacaccttctattggatacaagcttgtgat	CRISPR spacer
cgggtacaccttctattggatacaagcttgtgat	Protospacer
**********************************

129. spacer 3.17|57002|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gtcgcaattcgccgcaagcttcgttgcctgaactgt	CRISPR spacer
gtcgcaattcgccgcaagcttcgttgcctgaactgt	Protospacer
************************************

130. spacer 3.17|57002|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gtcgcaattcgccgcaagcttcgttgcctgaactgt	CRISPR spacer
gtcgcaattcgccgcaagcttcgttgcctgaactgt	Protospacer
************************************

131. spacer 3.18|57074|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aaaacactcgaacaagttggactcgctttgaacttca	CRISPR spacer
aaaacactcgaacaagttggactcgctttgaacttca	Protospacer
*************************************

132. spacer 3.18|57074|37|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aaaacactcgaacaagttggactcgctttgaacttca	CRISPR spacer
aaaacactcgaacaagttggactcgctttgaacttca	Protospacer
*************************************

133. spacer 3.19|57147|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ccaggaattagccgaaatcaaagcggctgcaagtga	CRISPR spacer
ccaggaattagccgaaatcaaagcggctgcaagtga	Protospacer
************************************

134. spacer 3.19|57147|36|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ccaggaattagccgaaatcaaagcggctgcaagtga	CRISPR spacer
ccaggaattagccgaaatcaaagcggctgcaagtga	Protospacer
************************************

135. spacer 3.20|57219|36|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

accgccgcaagtaagaagtctttcgctgattaatga	CRISPR spacer
accgccgcaagtaagaagtctttcgctgattaatga	Protospacer
************************************

136. spacer 3.20|57219|36|NZ_AP018205|CRISPRCasFinder,CRT matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

accgccgcaagtaagaagtctttcgctgattaatga	CRISPR spacer
accgccgcaagtaagaagtctttcgctgattaatga	Protospacer
************************************

137. spacer 3.21|57291|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctagagatgggacatgcaggggatgaggtatttgacgagcagtttgaa	CRISPR spacer
ctagagatgggacatgcaggggatgaggtatttgacgagcagtttgaa	Protospacer
************************************************

138. spacer 3.21|57291|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctagagatgggacatgcaggggatgaggtatttgacgagcagtttgaa	CRISPR spacer
ctagagatgggacatgcaggggatgaggtatttgacgagcagtttgaa	Protospacer
************************************************

139. spacer 3.22|57375|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

atgcctatttggaaaatctttggtaagcagaacgctaaccgt	CRISPR spacer
atgcctatttggaaaatctttggtaagcagaacgctaaccgt	Protospacer
******************************************

140. spacer 3.22|57375|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

atgcctatttggaaaatctttggtaagcagaacgctaaccgt	CRISPR spacer
atgcctatttggaaaatctttggtaagcagaacgctaaccgt	Protospacer
******************************************

141. spacer 3.23|57453|45|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgatcctatctatttggatgcaaatggcaactttgatccattcc	CRISPR spacer
ttgatcctatctatttggatgcaaatggcaactttgatccattcc	Protospacer
*********************************************

142. spacer 3.23|57453|45|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgatcctatctatttggatgcaaatggcaactttgatccattcc	CRISPR spacer
ttgatcctatctatttggatgcaaatggcaactttgatccattcc	Protospacer
*********************************************

143. spacer 3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tacatataggtggagcgcccgtccccccgtgtgggtgg	CRISPR spacer
tacatataggtggagcgcccgtccccccgtgtgggtgg	Protospacer
**************************************

144. spacer 3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tacatataggtggagcgcccgtccccccgtgtgggtgg	CRISPR spacer
tacatataggtggagcgcccgtccccccgtgtgggtgg	Protospacer
**************************************

145. spacer 3.25|57608|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tacagtcgattcaaacgcccgatcagctccctttacccaa	CRISPR spacer
tacagtcgattcaaacgcccgatcagctccctttacccaa	Protospacer
****************************************

146. spacer 3.25|57608|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tacagtcgattcaaacgcccgatcagctccctttacccaa	CRISPR spacer
tacagtcgattcaaacgcccgatcagctccctttacccaa	Protospacer
****************************************

147. spacer 3.26|57684|52|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tcacgctcgaagtgatcaccacttactgaactgcgacctacgaatgcatcaa	CRISPR spacer
tcacgctcgaagtgatcaccacttactgaactgcgacctacgaatgcatcaa	Protospacer
****************************************************

148. spacer 3.26|57684|52|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tcacgctcgaagtgatcaccacttactgaactgcgacctacgaatgcatcaa	CRISPR spacer
tcacgctcgaagtgatcaccacttactgaactgcgacctacgaatgcatcaa	Protospacer
****************************************************

149. spacer 3.27|57772|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgctagcggattagaaacaacggtcacgaacatagacagaact	CRISPR spacer
ttgctagcggattagaaacaacggtcacgaacatagacagaact	Protospacer
********************************************

150. spacer 3.27|57772|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgctagcggattagaaacaacggtcacgaacatagacagaact	CRISPR spacer
ttgctagcggattagaaacaacggtcacgaacatagacagaact	Protospacer
********************************************

151. spacer 3.28|57852|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aacaatggttatggtttagaatctgacaccgcagttgatg	CRISPR spacer
aacaatggttatggtttagaatctgacaccgcagttgatg	Protospacer
****************************************

152. spacer 3.28|57852|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aacaatggttatggtttagaatctgacaccgcagttgatg	CRISPR spacer
aacaatggttatggtttagaatctgacaccgcagttgatg	Protospacer
****************************************

153. spacer 3.29|57928|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tttccagctaggcttctaattccaggtcgagaaaaacagc	CRISPR spacer
tttccagctaggcttctaattccaggtcgagaaaaacagc	Protospacer
****************************************

154. spacer 3.29|57928|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tttccagctaggcttctaattccaggtcgagaaaaacagc	CRISPR spacer
tttccagctaggcttctaattccaggtcgagaaaaacagc	Protospacer
****************************************

155. spacer 3.30|58004|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

gcaaatcccctgacaccttgtctgtcagttatggcaag	CRISPR spacer
gcaaatcccctgacaccttgtctgtcagttatggcaag	Protospacer
**************************************

156. spacer 3.30|58004|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

gcaaatcccctgacaccttgtctgtcagttatggcaag	CRISPR spacer
gcaaatcccctgacaccttgtctgtcagttatggcaag	Protospacer
**************************************

157. spacer 3.31|58078|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

atcgagagcgatgtatcaattgccaaatcgctacaaaccaac	CRISPR spacer
atcgagagcgatgtatcaattgccaaatcgctacaaaccaac	Protospacer
******************************************

158. spacer 3.31|58078|42|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

atcgagagcgatgtatcaattgccaaatcgctacaaaccaac	CRISPR spacer
atcgagagcgatgtatcaattgccaaatcgctacaaaccaac	Protospacer
******************************************

159. spacer 3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tccatgaccaccggaatgccctcaaagacggggaacatccgcg	CRISPR spacer
tccatgaccaccggaatgccctcaaagacggggaacatccgcg	Protospacer
*******************************************

160. spacer 3.32|58156|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tccatgaccaccggaatgccctcaaagacggggaacatccgcg	CRISPR spacer
tccatgaccaccggaatgccctcaaagacggggaacatccgcg	Protospacer
*******************************************

161. spacer 3.33|58235|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

aagttattgagtcaaaaatgattctttctgaagggcgtaaaat	CRISPR spacer
aagttattgagtcaaaaatgattctttctgaagggcgtaaaat	Protospacer
*******************************************

162. spacer 3.33|58235|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

aagttattgagtcaaaaatgattctttctgaagggcgtaaaat	CRISPR spacer
aagttattgagtcaaaaatgattctttctgaagggcgtaaaat	Protospacer
*******************************************

163. spacer 3.34|58314|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cattcttgaagtttcaaagcaaaggcactaagcgcttcat	CRISPR spacer
cattcttgaagtttcaaagcaaaggcactaagcgcttcat	Protospacer
****************************************

164. spacer 3.34|58314|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cattcttgaagtttcaaagcaaaggcactaagcgcttcat	CRISPR spacer
cattcttgaagtttcaaagcaaaggcactaagcgcttcat	Protospacer
****************************************

165. spacer 3.35|58390|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ccgaccttcagtaaaggatttgaagctatgaaagagctttaca	CRISPR spacer
ccgaccttcagtaaaggatttgaagctatgaaagagctttaca	Protospacer
*******************************************

166. spacer 3.35|58390|43|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ccgaccttcagtaaaggatttgaagctatgaaagagctttaca	CRISPR spacer
ccgaccttcagtaaaggatttgaagctatgaaagagctttaca	Protospacer
*******************************************

167. spacer 3.36|58469|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

tagaatatggggggtgcactaatgcagatggcattctctggtga	CRISPR spacer
tagaatatggggggtgcactaatgcagatggcattctctggtga	Protospacer
********************************************

168. spacer 3.36|58469|44|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tagaatatggggggtgcactaatgcagatggcattctctggtga	CRISPR spacer
tagaatatggggggtgcactaatgcagatggcattctctggtga	Protospacer
********************************************

169. spacer 3.37|58549|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

atcgagacgttgcagcggaacggaagacagggaagag	CRISPR spacer
atcgagacgttgcagcggaacggaagacagggaagag	Protospacer
*************************************

170. spacer 3.37|58549|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

atcgagacgttgcagcggaacggaagacagggaagag	CRISPR spacer
atcgagacgttgcagcggaacggaagacagggaagag	Protospacer
*************************************

171. spacer 3.38|58622|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cttaaaataagaattaaaaagtagctgagtaagttacaaatggttcag	CRISPR spacer
cttaaaataagaattaaaaagtagctgagtaagttacaaatggttcag	Protospacer
************************************************

172. spacer 3.38|58622|48|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cttaaaataagaattaaaaagtagctgagtaagttacaaatggttcag	CRISPR spacer
cttaaaataagaattaaaaagtagctgagtaagttacaaatggttcag	Protospacer
************************************************

173. spacer 3.39|58706|41|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

cccgatcacgccacaatcacgccacaatcgtaaactgagaa	CRISPR spacer
cccgatcacgccacaatcacgccacaatcgtaaactgagaa	Protospacer
*****************************************

174. spacer 3.39|58706|41|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

cccgatcacgccacaatcacgccacaatcgtaaactgagaa	CRISPR spacer
cccgatcacgccacaatcacgccacaatcgtaaactgagaa	Protospacer
*****************************************

175. spacer 3.40|58783|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttgctgcgcgttggggttagtagtcagccggatcgtag	CRISPR spacer
ttgctgcgcgttggggttagtagtcagccggatcgtag	Protospacer
**************************************

176. spacer 3.40|58783|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttgctgcgcgttggggttagtagtcagccggatcgtag	CRISPR spacer
ttgctgcgcgttggggttagtagtcagccggatcgtag	Protospacer
**************************************

177. spacer 3.41|58857|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ctggctctatgtccgttgcttctcgttacgttctcga	CRISPR spacer
ctggctctatgtccgttgcttctcgttacgttctcga	Protospacer
*************************************

178. spacer 3.41|58857|37|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ctggctctatgtccgttgcttctcgttacgttctcga	CRISPR spacer
ctggctctatgtccgttgcttctcgttacgttctcga	Protospacer
*************************************

179. spacer 3.42|58930|40|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tggcatgagagcgttacaccattccagcaagtaagagttg	CRISPR spacer
tggcatgagagcgttacaccattccagcaagtaagagttg	Protospacer
****************************************

180. spacer 4.1|138871|54|NZ_AP018205|CRISPRCasFinder matches to NZ_AP018205 (Leptolyngbya boryana NIES-2135 plasmid plasmid2 DNA, complete genome) position: , mismatch: 0, identity: 1.0

ttcagcttgttgaatcagattaagtcctccattttcagttaagctctctatgaa	CRISPR spacer
ttcagcttgttgaatcagattaagtcctccattttcagttaagctctctatgaa	Protospacer
******************************************************

181. spacer 4.1|138871|54|NZ_AP018205|CRISPRCasFinder matches to NZ_AP014640 (Leptolyngbya boryana IAM M-101 plasmid pLBX) position: , mismatch: 0, identity: 1.0

ttcagcttgttgaatcagattaagtcctccattttcagttaagctctctatgaa	CRISPR spacer
ttcagcttgttgaatcagattaagtcctccattttcagttaagctctctatgaa	Protospacer
******************************************************

182. spacer 3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NC_008367 (Phormidium phage Pf-WMP4, complete genome) position: , mismatch: 1, identity: 0.974

tacatataggtggagcgcccgtccccccgtgtgggtgg	CRISPR spacer
tacatataggtggcgcgcccgtccccccgtgtgggtgg	Protospacer
************* ************************

183. spacer 3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to DQ875742 (Cyanophage Pf-WMP4, complete genome) position: , mismatch: 1, identity: 0.974

tacatataggtggagcgcccgtccccccgtgtgggtgg	CRISPR spacer
tacatataggtggcgcgcccgtccccccgtgtgggtgg	Protospacer
************* ************************

184. spacer 3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to NC_008367 (Phormidium phage Pf-WMP4, complete genome) position: , mismatch: 4, identity: 0.895

tacatataggtggagcgcccgtccccccgtgtgggtgg	CRISPR spacer
---atataggtggcgcgcccgtccccccgtgtgggtgg	Protospacer
   ********** ************************

185. spacer 3.24|57534|38|NZ_AP018205|CRISPRCasFinder,CRT,PILER-CR matches to DQ875742 (Cyanophage Pf-WMP4, complete genome) position: , mismatch: 4, identity: 0.895

tacatataggtggagcgcccgtccccccgtgtgggtgg	CRISPR spacer
---atataggtggcgcgcccgtccccccgtgtgggtgg	Protospacer
   ********** ************************

186. spacer 1.5|51640|33|NZ_AP018205|CRT,CRISPRCasFinder matches to MF141539 (Mycobacterium phage MyraDee, complete genome) position: , mismatch: 8, identity: 0.758

ttgatgcaatcgcgaccgtggcgcaactggaag	CRISPR spacer
cggctgcaatcgccatcgtggcgcaactggctc	Protospacer
. * ********* *.**************   

187. spacer 1.10|51641|33|NZ_AP018205|PILER-CR matches to MF141539 (Mycobacterium phage MyraDee, complete genome) position: , mismatch: 8, identity: 0.758

ttgatgcaatcgcgaccgtggcgcaactggaag	CRISPR spacer
cggctgcaatcgccatcgtggcgcaactggctc	Protospacer
. * ********* *.**************   

188. spacer 3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to MN692960 (Marine virus AFVG_117M7, complete genome) position: , mismatch: 8, identity: 0.771

atcaaagaaattagatcaagctagaaaagatacag	CRISPR spacer
acaagaattattagatcaagctagaaaagaaatag	Protospacer
*. *.*.  ********************* *.**

189. spacer 3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to MN692988 (Marine virus AFVG_117M76, complete genome) position: , mismatch: 8, identity: 0.771

atcaaagaaattagatcaagctagaaaagatacag	CRISPR spacer
acaagaattattagatcaagctagaaaagaaatag	Protospacer
*. *.*.  ********************* *.**

190. spacer 3.3|55947|35|NZ_AP018205|PILER-CR,CRISPRCasFinder,CRT matches to MN692984 (Marine virus AFVG_117M10, complete genome) position: , mismatch: 8, identity: 0.771

atcaaagaaattagatcaagctagaaaagatacag	CRISPR spacer
acaagaattattagatcaagctagaaaagaaatag	Protospacer
*. *.*.  ********************* *.**

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	131974 : 291391	89	Tupanvirus(25.81%)	transposase,integrase	attL 286431:286456|attR 293433:293458

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_AP018205|131974:291391|DBSCAN-SWA
TATGGAACCTATCGTATCGCGCCTCGACCTGACAGCTTTGTTCTGCGACGTAGACGACTTCTGCCAGACCTTTGAATGGGCATGGGCACACCAGCCCCAACTGCCGTCGATGCCTGGAGAGAAACGCAGTCGTTCCCGGTTGCGCTTGAGTGAAGTGATGACCATCGTGATTGCCTTTCATGCTTCTGGTGCAAGGACATTCAAGGATTTCTATACCCTGACCGTTCTACCGCATTGGCGCAAAGCGTTTCCGAATTTGGTGAGCTACACCCGATTTGTGGAACTGATGCCTTGGTGCTTGATGCTGTTGTGTTGCTTCCTGATGACCCGACGCGGCGAGATGACGGGGATTGCCTTTGTCGATTCCACTCCAATTGAGGTGTGCCATCCCGCCCGTGCCCACAGTCACAAGGTGTTCAAACATCAAGTGGGTTGGGGCAAAAGCTCAACGGGCTGGAAGTTCGGCTTCAAGTTGCATCTGATCATCAACGAACACGGAGAACTCCTGGCGTTCAAGCTGACTCCTGCCAATACTGACGACCGTGCTCCTGTGGCTGAAATGACCGAAGGCATCTTCGGCAAGCTGTTTGGAGACCGGGGCTATATCTCACAGAAGTTGTTTGAGGAACTGTACGAGCGCGGCTTGAAACTGATCACCAAACGCAAGCGCAATATGAAACAGAAGCTCGTCACGCTGATGGATAAGATTCTGCTGCGAAAGCGTTCCCTCATTGAGTCAGTGAATGACCAATTGAAGAACATTTGTCAGATTGAGCATTCTCGTCATCGCAGTTATTGGAATTTTCTGGTCAACCTGATGGCCGGGTTGATTGCTTACACCTATCAGCCCAAGTTACCGTCGCTCGATTTGCAACCGAAAGGGTTGCCTGCTTTGCCTCCTGCCATCTTTTAGCGTGTCGAACTCACGTCAATCTGACGCTCGAAACCTAGCAAAAACTGCGATCGCGGTTGACTAGGGCCGTACTTTTTCTTGCCAGCGCTTATTTTCGCTCTACTCGTCCTGAACGGCGCATCGATTCCCAAAGGATCTGAGCTATCTTATGCTCGAAAAGAGCGACCTGAAGTGGATCATTTTTAGGTGGTTTTGTGAGAAGGCGAACCAGCTCACTCATTCTTCCAAAGTCTTCCTCTGCATGTTCAAGCAGAACTAATAAGGCTCGAAAAATGTGACTAAAAGTATTGGGTTCACCTGTGAGGCGGTATGCAAAGTCCTGCCATTTTTTCCGCTCTGAATTTGTGCAGCGAACCCGGATTTCACTCGACATGATTTCTCGGCGTTCTCCGGCTTTGGGCTGAGATCTTGCCATCGCAGTGAGTGAACTTTGTGAATTCCCTGCCCCTTCATCAAGTTCAGTTGGCTTGCTCTGATCAAGGGGCTCAGAATCTTGAGGAACGGTTAAGGATTGATCTAAATCGCTGAGTGGGGAGATGACCCGCTGCAAGCGTGAGCCAACAGGATTGTAGTTAACATCGAGGACTGTTGCTCGCTTACCCATGATCAACCTCATCAAAAGTTTGACGATCGAAAAAACGAGCAATCTTTGCCTTAAACTCTTGCGCCATATCACGGAAGCACTGAGTAATGGCATGATCAGGATGCGTTTGGAAGATCGACTTCTGTTGGGTCTGGGCGGTGGGGATAATGGTAGAGCGCTGAATGACAGGTTTGAGGACGTATTCTTTGAATTCCTTATCCACATAGGCAATGAGTTCCCGACTTAGCCGAGTGCGGGCATCGACTGCTCCGATCGCTAACCCTACGAGCTGTAAATCTGGATTGCCGTATTTTCTCACTTCTTCAATGTCATGCAGCGCTTCTTGCAGACCTTGAATTGCCAGCCCTTCTGGAATGGCAACGAGCAAGAAACCATCCGCTGCTTTATAGGCCGCCACGATGGGTAGTGGAGCGCTAGGAGGCGTATCAAGAAAGATAAAGTCGTAGTAACCCCGTAGTTTCTTGATCACAGGCTTGAGGACATCATGAAGAGGCGTATCGTCAAACTTTGACTTCTTGGCTCGAAGCCGCTCCTCTAGCTCTTCTAGCTTGCGTGAGCCCGTCAGAAGATGAAGAGACTCTGGTAGGGAATGACCTTCATCTTCATGCGTCACGATCGCGGTTAGTGGATCTTCATCTCCAAGCAATACTTCAAACGTTCCCAGATAAGCACGAGGGTCGATGCCTAGATGCTTTGTTGAGCCCGCATTTACATCCAGGTCAATGATCAGCACCTTATGTCCCTGCTCTGCGAGCGCATAGGCAAGCTGAATGGTCATGGTGGTCTTGCCGACTCCTCCTTTTTGGTTGCCGATGCCAATTACAAGGGTTTGATGTTGGCGTTTCATACGGTGTTATGCAAAAAAAGTAGATAAAATCTTGCAGCGATAACTGACGTTGTTCCTACGTCGCGATGTAGGAACGTAGGAATGTTGTTACCGGAACTCTCTCAAACGGCTTCAGTTTAGACAAGCTCAAAAGCCCATTAAAACAGTGAAAAATCTAATCCTCTTGCTATCGCGCTCGCGTGGTGATGCTCCGCAATGTCCCTACGTAGGCATGTAGGCATGTAGGAACGTTCCTACGTCGCGACGATGTAGGACGCTCTTCGGGGATCGATTGAGCTAATACTGCGATATTGCAAACTCTTCTAAGCTATTGTCGAATGATGATAGGGCACGCTCAGGTCTAAGATGACGCTTTGATGACAAAGCATCCGCCGGTTTCACCTTTCTTGAGATCAGGAGAAACGAGCAGTGCAGGGGTGAGCTTGTGATGAAAAAAGAAGGCTCCCGCACTCAAAGATGATTCGATGAAAATGAGAGAGCCAAAAAGATCAGTCAGGTCTAACGATCGAAAATCAATTCCAAAGAAGAAAGCAAATGCCTAGCCCGCATCTGCTTCTTTCGTTCTCTGAAGGTTCAGAATGAATTTCTCCGGTTAGCTTCTAGGTAGACTAGAACGACACATTTGGTTCGTCAAGAGATTAACTCTGAGTGGGTTTGTGCGGTTTGATTTTCGATCTCCACGTTTGGAGGTATCGAAATGCATTCTACTCAATCTTCTTCGCCCATTGAAGGGGGATACTGCCTGCTTTCCCAAGCGACCCTTACGAATGTCTTGGGCGCACTCATCGATCGCGCCATTTCCTATCGAGCGGCACGAGTCTTTTTTGCCTGCTGTTCGATGCGATCGATTCGAGAAGCAGCGGCTCGTTGTCAGATCCGAAAGCACCAGAAGATTCAGTTTCGATTCGACGAGATTCGCCAACGTGTCGGCACTCAATCTGAGAAACTGATTCGAGCGGATTTAAAGCAGCTTGAGCGATCGGGCCTTCTCTCTTTTACTCAAGATGCGATCGAGGTTGTGACCGTTCCAATCAACTTCACGCAATCGTTCGATCTAGGTCGCTCGATGCGACGACTCATTCCAGTTCCCCGGCGCATTCTAGAATATCTCGCCCAATGTCCCAGTCCTTCCGTACTGCGTGGCATCATCGTTTATGTGCTCAGAGGTCTCACGCTTCGTCAAGGGATTGTTTATGCCTGCGGCTCAGTTAAATCCTCTTGGGTCGCTCAGATTGCTCATATCAGCCTTCGCGCAGCGAAATCAGTTCGTGCTCATTTGATTGAGATTGGGTGGCTAACCAAAGATACTGGCTCCACTCAGCGAAAGCTCAATGCTACAGGTGCTTTTTTCCGCATCAATACTCAATGGAGGCGATCGTCTTCTACAACGAAGCAACCTCGGGCTGTGGATAACTCGACAACTTCAGATTCTCAATCTGCACCCCTGATCGCAAAATTGGGGAGTAAATCTGCACCCCCAATACAAGACTTAAAAACTTCTACGAACTCTAAAGACCAGAAATCTTCCAAATCACTTCCTGGTGTTTATCAACAAACTCAAAAAATTTCGCCACCGATACTCCACAACATCCAGGCAAACGACCTGTATCATTTTCACCGCTTGGAGCTTCTGTATTGGCAAGCGATTGCGGCGAAATGGCTGATCCACTCTGAAGCGAGTACACTCAATTGGATCTGTGCAGCAGTCAGGGCGCGAGAAGTTGTCAAGCGTTCAGGCGGCAATGCCGTCAAAGTTTTTGTCACGATTGTCCGCCGCAAACTCTGGAATACAATTACAGGAACGCAGGAAGACTACGCTCGCAAAAGCCTGGTTCGATTTCGAGAGACCTGTCCACAACTTTTTCGTCACAGGAGCGAGAGCGATCGCAGGATTTCTGTTTGAGCTTTTCTGACTCAATTTTAGGAGATTTACATTTCGTTGCTACATCGCTACGGAGCTTCCGCAACTGCCTGATAACTTGCAAGCTCACTGAGCGAACAGTCCAGCTTCTCACAAAGAATCTGCATCTGGAGTGGAGTCAGTTTGGGAAAGCTTTCCCCTGTTTCCCAGGAACTAATGGTCTGCTTGCTTAAACCCAAGGCTGATGCCAAATCCTTTTGTCGAATTTGACTCCGTTTTCGTTTGAAACAGAGCCACTCACTAAAAGTCATCGTAGATCCAGGAAGGGTCATAGCTGGAGTCACTGAGCGAAAGACGTGGAATAAGAATACCTCAAATTTCAGATGAGTAGGTCAACTTCTTGACCGTTTTCAAGATGAGCTGTCTGATCCACTGGACAAGTCCAGAAAATCATTCTTTGTCTGGCTGTGTGGATCAAAACAGGGATTTATGGATTTGTCCGCTTTAGGATTACTTTCGTAACCCGTGATCGCAGCAGCTCAAAGGATTAAAATAGAAGCTGCCAATAGATACCGATGCTGCAATTGCAGCATCGGGTTTGCCTGAAGAGATATCAAAACTCCTTCAGAGCATATCAGACCATTTTTTCTAATTGCGCTAAAACATTTTTCAACACTGTTTTAAGCTCGTTCCGCTGCTCTACAGGAAGTGCATCTTTAAGGCTTAAATCGCGGATAACGTGAATCACTTGGTCAACCTGTTCATTGCGATGTTCGCCGGATGAATCTTCTGCTTCCCCACTTTTAGAGGATTGTTTTCTTTGTTCAGCTACCCATCGTCTTGTTTCGATCGTCGATAAGTTCCGAGAGGTCACTTCTTTGATTGCTTTCTGTCGCAACTTTAAAGCTTGTTTTTCTGTGATTCCAAGCTTTTGAGCAGACAGCCCATTGAGAAGTAATGCTTGAGGACAGCCTAGCCGTTGAGTTCGGATTGCTGCTTTTAAGTCATCAAACAGGTTGAGTGTAGGAAAAATGTTGCGATTGAGAGAAGCTGGGTGTTCCTGTAGACCAAGAAAGACCAAAAACGTTTGAACTTCGATTTCCTCAAGCCCAAGCTCTTCCAGTACTCTCTGTTGTTCTTCCTGGGGTTGAAGATGTAAACGATCTCCAAGGGATTGATTTTTACGCTTCAGCCGAATCAATACTCGATTTACGATGCGGGATACATCTTCTTGGGGTAAATCTGGAATTTCATCACTCGCGATCGCAACCAGCGTTTCTGCCTTGTCAAGTGCGTTTAATCCTCGACGGTGCAAACTGGTCAGATAAGCTCTGCGTCGAAGTGTTTTATCATCTTGAGGTCGGGCTGTGAAGACAGCATCAATGGTTTCCCACCCCATCGCTTCAGCCGAGCGCCAGCGACACTCTCCATCAAATAACATTCCATCTTCAAACAAGATGATTGGATCGAGTTGCCCTTCTTTTAATAGAGATAGCCGCATTGCTTCGACCTCTTCATCAAAGGTCTGACGGGGCTGGTTCGGGTTTCGATGAACTTTGTTGACTGGGTATTTAACGACTCCCTGAGTGCCTTTGAGATGATCTCGCAATACCCCGATCTGCGTTTCAAGTTGCGCTTGCTCTTTTGGATCCAGCATTTGTGATCTGAGATGTTCAATCTCACTAACAAGCTGTTGTTCCCGCTCTACGTTCTGGCTCAACTCTTCTTCTAGACTTTGAACTTTGCCTCGCAGATTGTGAAGTTCTTGGTTCTGATCGACTTCACTAAAAAAGTTATCTATGTCGAGTCGATCTCGCTTTGCCACGTTGCTTTCCTCCCAATTCTTTCACAATATTATTAACGATCGCCTCAAGCGGCTCGATAGCTGGGTGGCTCGTTCGATGTACCCTTAATGGCACCCCCTCTGACCACGCATTTGTGAATGCGGTGTAATGTCGGATCATCGGAAAAACTTCATAGCCTCGCGCTTTGTAGTAGGGCGGTAGCTCTTGGGACAATCGCTGATGTTCCGCCCCATTTTCAACATTATTGATGACAAAACCTAGAATTTTAGGTGGCGAATCAAGTTTGAGTTCTTGAATACTCGCAGCATACCAGTCTAATAGTACTCTTGTTCCGTCAATCGCCTTTGCATCAGGCACTAACGGGATGAGCAGATGAGTTGCAGCAACCAGAGCTGCTTTGGGAATTGTTTCTAGCGTTGCAGGGCAGTCAAAAATAATAAGATCATGTGGCAAGGGATATTGCTCGATCGCATCCTTGAGCAGGTCAACTCCCCCAGTTTGCGCCAAATTTGGCATCACTTTGAAAAGGGCATTTCCTCCTTGCAATACCTCAAGGGTCTTAACATGATTGCTCCAAACGGGGACAAATGAATACGTTCCATCAAAGAAGCCTGAGAAGATCCAGGCGCAAGTTGTTTTCGGTGCAGGGGTCTTATTTAGGCGACAGGCAACATTAAGCGAACCTTGAGGGTCGAGATCAAACAGCCCGACTTTGTATCCTAATCGAGCAATTTCGTACCCCAGGTTTGCTGCCAACGTGGTCTTACCCACGCCCCCAGCCCCCGTCATAATTGCCAATCTGATTTGCTTTGCCATGGGCCTCATTATAATTGTGAGGTATGTACCGTAGCACTACAGTACACGAAATTCAGCTTGTTGAATCAGATTAAGTCCTCCATTTTCAGTTAAGCTCTCTATGAATGAGGTATGTACCGTAGCACTACAGTACGCGAAACCTGGCTTGAATTTATCAGATGTTTGTGGACTGAGGTTTCCTCAACCAACAATGCTCGATTACGCAGTTTGCCGAAAATAGGTCGAGAAAACAGCGACTTACGACTTTGGAGCATAGGTTCACTGTATCGACGGATTAATGGTATTACCGTTAATAAGTGGCTTGCTCGCCTAATTTCTTGCTCTAGCATCAGAGACGGAATAATGGTAATACCATTCGATGGATTCTTCTCGGCGACGCATCGTTGTTCCAATCTCTCTTCAACCTGCTGATCGAGCAAGACTTGAAGAGTTGCGATCACGCTTTGCCACTATTTTAAAGTCGAACATCAATACAAGCGAAACGGTTCGACTTGCGATCTCAATTGGCTCTGCTGCTTCTCATGAGCAAGTACGACAAGTTGTTCTACAAACAACGCGAATCCCACGCGGTCGCCCTCCTATACCTTGGACTGCTCGCTATTTAGATGATCAGGAGGAAGAGTGGGTTAGAGAAGAGCAGGAGCGACTTCAGCGCCTCAGATTGATACATGAACTTCAAGTTCTGCGATCTTATTTGGTAAGAACGTCAGATCAAGAGAAGCGATTAGAAGAAATTTGTCGTGAACTCAATATGGTGCTGGCTTAGCAGGTTATCTCTTAGAGCCGATAGAGAATGACTCAGACTCTGTGTATTGCCCTCAAAATTCTGTTGCAACGTCGCAACGGAAAGATTTCTCTTTAATTTAAAGTTGAAATTTGCGATTGTATTCCAACGTGATTTCCGTAGCCGAACAGTTCTGAGCATGTTGCTAAACCTAATATTTGAGTATGAAGGCGGAAAACGACGCTGTCGCAATCAATTTGGTCGAGGATGTCGATACAAAACAAAACGTTCAGCTAATTCCTCTCAACTGCATTCAAGTTGGCAAGCAATCCCGAACCTATTTTTCGCCACATAGCTTAAATCTACTTGCGCAATCCTTTCAAAGGTATGGATTTCAAGGTGTGATTAATGTCCGTTATATTGATCGAGATTGCTATGAAGTCGTAGCAGGCGAGCGCCGCTTACGAGCCGCTAAGCTTGCGGGCTTAAAGGCTGTTCAGTGCATTGTCGGAGACTTTACGCCTGAAGAGGCATTAGAATTTGCACTTCGAGAAAACCTTCAGCGCGAGGATCTCAGTAAACTTGAAGAAACCGAAGCTCTGCTAGCACTATTGTCTTTGAAGCTCAAGCTAGAGCAGTCGCACATTATCGAGGTGATTAATAAAGAAGGGCATCTCGACCGACAGAAAAATAATCAACCTAAAAGTACAGAGTTGCAGCAGATTGAATCGTTGCTCGGCTCGTTTGGAATTGAGCTTCAGACATTTCGGACTAAGAATTTGCGAACGCTCACTCTCCCCTATGAGATTCGCCAAGCTCATTTAGAGGGAGGATTACCATATTCCTCAGCGTTAGAGATTGGCAAAGTGAAAGATCCGACAGTCCGTGCCAATGTTCTTCAAGAAGCATTAGCTCAAGGATATTCAGTCCGAGATGTGCAAAGCATCGTTCAACAGGTCGCTCAACCTTCTTCTCGTGAGACATTAAAACCGAGCGATCGGGTTCATGCGATCGCGCGTCGGTTAAAAAAAGTAGAAGCCTCTATTCGAGATCGAGTGAAGCTGGATCAAGTGATTGATCAATTCATTGATGTGCTCGAGGAGATTGTCAAGGATCGCGCTTCCTAATCCGCTTTTCGTTCGAGTCTTAGATGCAATTCGACGCGGGGGCGATGAGATTTACGACGCATTCGATTCATCGTTTTGACGAGCTTCAGCTTTTGCCGAATCACCCCTGGGAACGAATAGAACCGAAGATTGTTCATGGCAGCTTCGACTTCTGATTTGGGACGATGTGCGATCGCGAAAAGATAGCGCTCGATCGGTTTCCAGGTACGACGCGCAACTTGTACGCAGGGCACTCCACCTTTCATCCCGATCGAGTATCCTGCAAAATGGATCGGAGCAATGCGGATGTCTCGCCAGCAGATTCGATCAAACGCGGGATGTTTCCCTTCAGTTGCGAGCAAGATAAAGCGATGCCCTTGCCGCACAAAAACAACGTTTGCCAGTCCTTGACGTTTCCGCCTTGTACGAGTCATGCGACATTGTGTAATGTCATAGGTTTCGATGAGCTTGGCATCGACGTGTAATGGATCTTTGCCAGCTGGAATCTCTCTCATTGCATATCGGTAATATCCGAATCTCACATAGTCGATCGCGACGCGACGAATTAGCACATGGAGTTCAATGACGACAAACGAGTAAGACATAGCGATTACTCGACGGAAAAAAGAGAATTGATTCAGGGTAAAACCCCTCGGTTCAATTCTCAAAAACCGAGCACCAATCCAGTTGCCATCTGCATACTTTCCAATTTCCATTTAGACGGAACATGGAAGGATTTTTCAGCATTGGGCAACCGTTTCGACGCAGCAAAAACGACTTTAATTTGACGTTTTCAACTTTTCGACTTTTAGGTTTGTGTTGACCCGTGGGATACGGAAATCGATGAACGGTCGAAAAATCGTATTTCAGATTCCTCGAATCGCTCCACGTCTTATCGTTGAGAAAGCTTACACCAGCTTTGAATTTGACAATGTGAAACTGAGATGTCGTCGGTCCTTTTGTTTTCGATTGAGCCATTCACGGTGACTCTCGAGCGATCTTAAGACTGGCAGCCCTTTGATCTCCTATCAGACCCCGCTCATCGATCTACAGAGTTTGAAGTCCGTTGTGCTTTGCAACGAGCCGAATTGATGATCCGGTATCTGTAGATGTTGCCCGTTTAGCACTAAAAGTCGAAATTTCCGTAGGTGTTGCTAGTGAATTACTACTCACAAGAATCGTCGCTAAAGGCTTAGCCTTTCCCGTTGCAGGTTTGGGGAGGTAGAAACCAGAAAACCCTCCTTACTCGCTCCGACCCGATTCGCGCTTTGCCCTGGCACCCTAGAACTTCTCACCTGTAAGCAGTTTCCAGAACTAAACCGCCGATCATCGTTGAGCTATTCATCGACTCTGTATTGCAGACTCGCCGGAGAGAAAGCGACTCTCCGATTCCAGATGTCGCCATCTTGGAAACTCCCGACACAGGCTGAGGTTATGTGTCTGAATGCGTTCATTCTGGCAGACTTCATCCCCTCAGTAGGATTTACACCCCCATTCTCTTAGTACGGCTCTAGCAATTCTTTGCTAAAGTCTGTCACGGTCGCCCTGTTTCATTGAGATTGAATAGAAATGTAGGAATTGTTCCATTGCTAGAATTTTGCGCCTACATGCCTTCATCGCACCGGACGAGCACCTTTCAATGCATCCGGCGCTACGACCTACATGGTCTCTTAGGCTTGGACGTGACTCCAAGCTTTACCGAGGATGTAGCTCAGCTCCTTGTCTCATCAACAATTATCCGTGTTCGATCATGAATTGCCTGTGCAATTCAATCGGAAGTTTAAGGCGAGTGTGGAAAAGATCAAGAAAAAACCTCCTACGGACGGTCAACAATGCCCGTGGAGGTAAAAAAAAGTCCCACGGGCGTTGTGACCGTCCGTGATCAACCTTAGCGGCACTAGATGTGCTCGGTAACATTTAGAAATCTGCTCCTCTCAGCGAGTTAGAAGAAGCGCGATTTGGGATTCAGTATTTGAGAGATGAGAATGAAAAGGAAGAACTATTTTCCGAAATCTTCTGATTTAGCACAGGGTCGATGACAAGCAGGTGCAACAGTTTGGGTGCTGGCAAAGGCAAGACGCGCAAAGTCTTTGACATATCTCCGTGCTGCTGGGGTTGGGATTGGAGTAGCTATCGTGCTTGGAGGATTTGCGCTGTCTGGGGCGTTCAGAATTGTGATGCTTGCCGTCTGCTTCATCGTGGTACTTGTTGCTGGACGTGCTCATTACTGGAAAGTGAGATCGTAGCAAGTGGTGCAAGGAGCCGGAGCCGAAACAGCGATCGCAGCAAAGCTCATTCCTTTAGTGCAGCAAAGGTGGAAATTTAAGTTTAATCAGCCTGTGCCTCGATACGGCGATGTGAATGTCTTTGCGATTTCGCCGAATGGCAACCTTTATCCGATCAAGGTCAAAGCAATAAAGGGAAAAGTTCACTGTGAGGGAGGGCGATTGTTTGTTTTACCGAATTCAATCAGAGAGCGTTCCTTTGGAGGTCGGAACTTGCTGCTTCAATGTCGGGGACAAGCTGAAGCAATCCGGGTTCAATATCGTATCAGAAATGTATATCTAATTCTCTGCTTTGCGAATGCTGTAATGGATCTCAAAGTTTCATCGATCGACGGTGTAGAGATTGTGACAGGAGCTGATGTTGTAGAACGTCTCCAACTGCTCGATCGACAACTCAACATGATGAACTCAACGCCCTATTGCTGAATTAACCAGACTGCTCCATCCGAGATATCGTGATAGAACGTCTCATCTGTATTAGGTTTCTCCTCGATTAGAAATCCGCCGAGTAAAAGTCCTAGCCAAAGCTCGACGATCGAAAGTTTTCTCATCGACTGATGAATCTGCGCAATTGGGATGGGCTCGTTAATCTTCTTACGCTTGAGCCAAGCTGAGATCGCAACGCTCCATCCAGTTGGGTCTTCATCCCCTGCAAGATCCTGTAGCATTTTCAGGACGCGCTTCGGCGGAACAGGTGCGGCAACTGAATCGTTTGGTGCTCTGCGAGAAGCAACTTTTTTAGGTTTTCCCCATTCCTCCTCATCGCTTTCGAGATCCAGGCTCATCGTGTGTCGTTCATAGGCATGATCATCGTCATCGAGGACTGGGAATCCGGAGTCTTCCTCGTCAGGCACATCCGTTTTATTCACCTCCTGATAAGCCATCATCTTCAGGTAGAGAACTTCGGCAATTAGTGCGATCGCATCTCCTCCGATTTGGAGACAAACTGCATCCGGCTGCAAAGCGATCGCATCTTCTAGCAACTGACAGAGCGAACGGCAGTCAGCCTTAACAGGTGCTACAAGAGCCTCTTGAAGTGCGGCATGAAGTCTTTGCCGCTCATCCATGTTGAAGACTCCAGGGATGATTAATCTTGCACTCCCGAATATGCTTGTGAATCGTCACAAATTTCTTAAAGTGCTTTCCTTGATTGAGCGTGGCACTATATTGAGCCGTAAATTCAGTCAGAATCTCTTCCATGAGTTTTGCTACTTCATCTCCCCGCATTCCCCAACAGGCAATGGGTTCACGTTTTGTATAGCATTCTGTTCCCACCCAAAGCTGGAACTCGATCGCATGAACCAAAGTAACGTTCTTCTTAAAGTTATCAGGCTCTTCAGAAAAAATGATCCGAATCGGCGTTGGGCGTTGAGCAACCGGAAAGCTGACCTGAGCAACAGTTTGTTTTGCCTGCTGTCGGAGGCGATACTCTAATCGACGTTTAGCATTCTGTTCTGCTCGATTTTGATATTGCCATCGCAGTTTTTCACAACGATTCTCTTCCTCAACCCAACAGCCATCGCCGTTAGGTCCATGTTCCACACGCGCCCATTCAACGGAATAGGCTGAGCATTCTAAGCATTTTGGATTAATGGGTCGAGCCATAGAACGATTGCCCTGTCTGGCATTTTGCCACGTTTTGCTGACTGCCCACAGCATAACATCAATTTTAGTAAGAATTTTAGTAAGAATTCTTTTAACTTACAAACAGACAAAAATAGGCATCGTTGGAATTGTAATCATCAATTCTTAGTATTACAGTTGTAGATCTAGGATTGAGAACGTTTGCGGTAGTGATGGTATCGAGCGACTGCTTGATGCACTCTGCGCCAGTAAGACCAATGCAAAATGGATTCAAGTGACCAAACCTTTGGAAATAGGAGTCTCCATATCCAACGCTGCATCTCCCACGAACTCAATCTGATGATTACCCTCTGAACACTTTGAACGCAACCGGAGAGCCAACTAGAGCCAAAGGGGGGGAGGCACTATGAGAGCATTGTATCAGCGGTTCTACTTGAGCGCGCAGTACAGTCAGGAATGCTTGTGCGGCTAATACTAACGTCATGTGCCGATGCCAACCCACCCAAGAACGAACCTCGTAATCTGCCAAGCCCAACTGACTCTTTGCCAACTTGAAGCACTCCTCGATACCCCACCGTTTTCCTGCTACTTTCGCGATCGTTGCTAATGATGTGTCCTTAGGCGCAAAGACTTGGTAATAGCTAACGTGTTGCGGTGGGTCGATTTGTTCCAGAGAACGACGAAACACTAACCACCGCTGAAACCTTCCGGAATCGCCACAATTGATTGCGACCCTAGCCCATTCATACTCTCGTTCTCCTTTACTGCCTTGACCACAACTCAGGCGTTGCCATTGCTCCGGTGGCACAGACAGACAGACTGTGAAATGACCCCTTGAAACTAGACCACTTCCTTTGTCGATAAAAGCAGCATTAGCTACGAGCTAGTATACTGCTATTGCTTATTCTTTTTCGTGTTTGTTTTATTGATTGCTTCTCCATTCACTTTCAAACTCAATCGGTGTTAGATATCCAATTGATGAATGTATCCTCTTCCTCATGTACACTTCCTCCAAAAACACTTTGACCTGCATGTAGACTTCCGCAAAGTTGCGATACTCTGATAAATCTACTTCCTCCTCTTTGATGGTTCGCATCAATCTCTCCGCATAGCCATTCTGCGTTGGCTCTCCCACTTCTGCCATGCTGATTTCAATCTTGCGTTGCTTGAGCACCTCGACATAGCCTGTCGCTGCATATTGCACTCCTTGGTCGGAGTGATGAATCTCAGGTTGGTAATGTTCGAGCGCTTTGTTCAATGCAGTTAAGGTCAAGCTGTGATCTAAGCCTCGCCCTAAATGCCAACCCCGAATACACCGAGTAAATACATCCATCAACACAGCGAGATAAACAAAGCCTTCTCCCAATCGAATATAGGTGATATCACTCACCCAAACTTGGTTAGGGCGTTCAATCTTCAGTCCTGCAACGCGATTCGGATATCGTGCAAAGCTATGATTGCTATTCGTGGTTCGGCATCGCCGTTTTGGGGCTTTGCCTGCAATTCCCATCTCTTTCATCATTCGCGCCACCCGCTTGTGGTTCACGACGATGCCTTGCCGTTTCAGTTGCTGAGTGATCCGTCGATATCCATACCTTGGAAACTCCCCTGCAATTTTGTCGATTGCGCTTTTCAATTCTGTTTCGGTTGCAAGTTCTTCTTCAACGGGCTGATAGTACAAGCTACTCCGATTCACTGATAGTACTTCACAAATCTGCCGCACTGAATAGTGCGGTTCAAGTTCAGCTACGATTTGCCGCTTTGTTTCATCACTGAGATGCTCGATGCTTTTTTTGCGATCTCTAACTGCATCGTCAATTTTCCCACCATCTGTTCGAGTTCGGCTATCCGCGACTCGACTTCCGAAACTTGTCCAACTTCGCCAAATACAGACGACGCTCGTTCGACAAATTCGTTTTGCCACCGCGTTAATACACTGCGATGCACCCCGTGCGCTCGACTGATCTCGGTTTGCGTCTTTTCTCCACGCAGCAGTTCGAGGACGACTTTGGCTTTGAATTGCGGGCTGTATTTCTTGGCTTGATTTGACATGCACTTGATCCTACTCCTTAAACGGTTTCTTGTCGCTCTTGGAGTGGTCTAGTTTTTGGGGGGCATTTCACTGCTTCGGCTCGATTAGGTTGCCAACCTATCACCACTGGTTGTTTTTTGTTCACGGTGAGTACGTAAGGCTGTTGTCCAGTCTTCTCTAACCACCACCAGAAACCAGCATCGTTGCCATACACTTCATCGGCAACTACCCAAGCAGAACGAAGCCCAGCGTCCCATGCCGCTTGCAACATCTGTTGAGCGAGTTGCGCTTTGGTCGCAAACTTCACTGTTTTTGGTACTCCTGCTTTAGATCGCTTGTCTGCATCATCCGCCCAGGATTTCGGCAAATAGAGGCGACGGTCAATCAGGGTATGACTTTTGCCAGTAATGTAGGCTAAAAAGACACCCACCTGACAGTTTTCCAGATGTCCGGTTGTGCCGTAATACTGAACCTGCACCCCGACTGACTGGTGTCCCTGTTTGAGAAATCCTGTTTCATCCACTGCGAAGATGTCGTCCGATTCGCTCAAACCTTCAACCCCATACTGCCGCACTTCCTGACAGACTTTTTCCGCATCCCACTGGGCACGCCCTAACAGATGTTGAACTCGGTAAGGATTCTCATTCCCGACCTGTTCAGCAATTTGCCAACCATTTTTCCGCTCGACGGGACTGAGCAAGGCTTGAATGTAATTGAAAGCTGCTTGACGCGCTTCAGTTCGAGCAAAGTAAGGACTCAGTCGTTGCTGAAACGATTTCAGCGTGTTACTCCACTCGTAGACTGTTTCTAATGCCTGTCCAGTTAGAAAGACTTGGGAAGGGTCAATCGAGAGCCTATCCATACAACGGTATATTCCAGATAGTTCTCTTCAGTCTAAGCTATCTACAACTGTAATACTTAGAGGGTTTCTGTATCGACATTTCTAGTGACGGAGAGGGTAACGAATTTCAAGCCTCTCCTGACGATCAATTCACCTGGCTTGTCGAGTAAAATCGCGAACATTGCCTGGGTGAAAGATGATGAGACGTTTTCGAGTATCGGCTCTAACCATGAAAGAATGGATGGCGCGGTTATTATTGGTAGGCTTTTTGATGGGTGTTCTGCGTCACCATCAAATTTCCAATCGTCTTCAGCAAACGTATCAGAATATGACTCGCTGGCTGAGCCTGACACTCGAACGCATTCCAACGGCTTGGTTTGTTACAGGTGCAGTCGTCATTCTGGCGTTGATTGCTCTGTGGGTTGAGAAAGAAACCTCGATCTCATCGATTCGGGATGTTGTGCAAGTCATATTCAAGAATGCGGAATCGATCGCGGTCGTTGCCGCAGTGATTTTGTATTTCAAAGAAATTCCTGAGCGTAGAGCGCAGAAGCACTACGAAGCGTGGCAGGTTGTTGATGCAGCTGCAAATGTGTCTGTAAGTTATGCGCGAATTCGAGCATTAGAAGATCTCAATCGAGATGGAGTATCGCTCGAAGGCATTGCAGCAATGAATGCTAATTTAGAAGGCATTGCGCTGAGAGGAGCGCTCTTAACTGAAGCGAACCTAGCTGGAGCGAATCTCTCCGCTGCCGATTTCACGGATACGGTCTCGATGAAGATTCGTTTGGGGCAAGCAACATTAAAGCAAGCCAAATTAAATGGATCTGATCTCACAGCAGCAGAGTTGGAAGGAGCGATTCTGACGCAGGCAAAATTGATGAACGCTAATCTGACCGGTGCGAAATTTACATCCGCTCAATTGGCATATGCTGATTTGTCGGGATCAACGTTCACGGGCGCAACGTTGACCGGAGTAAAGGCAGTCGGTAGCAATTTCTACTATGCAAAATTGTATGAGGCGAATCTGAGTCAAGGCAATTTCGCAGAAGCCAATTTTACCGAAGCTGATTTGACAGGGGCAAATCTAACAGGAGCGAATTTCAAGGGAGTGAAGGGTCTCACTGCAAAGGCAGTAAGAATGGCAAATCACTGGGAAAGCGCCGTGTTTGATCCTGAGTTGGCAGCTCAGTTGGGAATGGCATCAGATTCTTGATTCTGAGGCTCAGTCTCGATCTGAATGAAATCAGTAATTTTATGCTTTCCTCTATGGAAGAAATTGTGTTTTTTCGGGTCAATTTGGTGTTGTTCATGGTGCGCTCTGATCTCCGCTTCACGTTGTTCTAATCCTCTTTGAATTGCGGGTTGAGAAGACACAAATTCCTTGAGGATATTGATGCTAATTGCCCATTTATCTTGATGCAAACGCTCTGCCATATCGTTGTAAGCCATCATCGCATCGATCGCCCGATCGACAATCTCTCCTGATGCTCCTCTAGGTCCACGGGGACGAGCGGGTTGAGGATTCTCTGTTGATGCTGTTGACGATTGAGTTGAATGAAGTGTTTGGGTCGAGGATGGGGTTGAACGTTGCCTTTGAGGGGAGGTGCGTTCTAATTGTCCTGCGCTGATTGCATCGGTCAATTTAGCGACAGACTGCATAACCTGAGCCATTTGCTCGACTAAAAGCTGCACGGTGGGATCAAGTTTGGGCGGTGTGTCTTCGATCGGCTGGATCTCTAAAGACGGAGGTTCAATTTCGACTATAGGCGATGGCTCTTGCGGTTGACTTGACGCAGGTTCAACGGGTGTTTGCTGAAATTGGGCTTCGATCCACTCCAGTAGTTTGGCAGTCCGTTCAGATTGATTCTTTGCATCAGGTGCGATCAACTGCAGAATCGAGATCCAGCGATCGTGGTCTTGAGTGTAGTAGCTCAACGTACTTCTTTTTCTGCTTGTCCGTTTTGGTTGTTCTAACTGTTCGACGGATGCTTCCTGCTTGAAGGCTGCAATTGGTTCAATACCTCCATGCCCTAATTTGATACCTTTGCGCTTCCCATGATGCTGCGCGATCACCGAGTCAGCAATATCAAAATCGGCATAATGTCGAGATGCCGCTAGCGATCGCTTCAGCGTTGGACTTTTCTTGTCCAGAATTTGATAGTGTCCCTGAATTGCTGCCCGAAACTCAACTGTATCGATATTGGCAGGACAATACCAAAATGTGGCGATGGTCGCATACACCGCACGAAAAAGATGAGTATATAGATTGCCTCCAGCTCTAGATGGAACCAGATTCTCGAAATGTCGATCGCAAGCGACGGCAACTCTTTGACTAAATTTTTGATTGATCTTGTTTGCGCTCATCGATTGAGCTTCTGGAAGCTGTTGGCGAATCTTGGTGAGCGCTTTGCAAACTTTATCAGCAGTGGTCAGCGTCGGAATCTCAAAACTCAGCGTTTGCGTCTCTTGGCGTCGTTTTAATGCGCCTGTAAAGGTGACACTCCACTTTGTTTTTGGCTCAAACCTTGCGGTTGCCAGAAGTTCTGTCACTCTGCGTCCAGTGAGTACGGCTAGACCTGCGGCAACATCAGCCCAATCTGGGCGTTCCAGGAGTCGAACGGCTTGAGCGACAATTCTGTCCGGATCATGAATGTATTTCACATCTTCATTGCGTTCAGCGACACTACGCTGCTTCTCATCATTAAGCGCCGTATATTCTTCGGTAGAGAACGCGATGAAGTCGAGAGAGAAGTGATCTTCGCCCAGCCCATCCTTGATCGCTCTGCGGATTTGATCCATGCAACCTTGTTGCTGTTTTAGAGATATTAGCCCCCGCTCTGCCCAACTTTGACGGAGTTCTTCGGTAAATTTTTCTAGCTTCTTATGACCAGCCGCCGTATTCTTCACGGATTGGATGAAGGGGATGTATTGAGATTGAATCAGCTCGGCAAGCCACTTTCTACTAGCCATGATATCTGTCCAAGAAGTCGTGTATCAATATCATAGCTGATATGCATAACAATGCAATCTTTATTTATGTATATCAGCCATGCATTGCTTCAATCTTTTCTGATCCAAAAAGAATCGCAGGTCGGTGGTCAGATGGTTCTTTCATTGCCGATCCCTTCTTGATGAGAATTTCGGCGTGGATTGCTTTTTGTATTGATTTTGCAGTGTATTTGCATGGCGCTTGATCGCACCCGTCCCACCGATTTCAAAACGCTACGATTGCGATCGCTCAAAGTTGGACTTCTCCACAGCGCGATCGCGACTGGAGTGATTGTTGGACTTCTTGCTTTATTTCCTCAGATTGCTCGTTCTCCGTTGCTTTGCTACTTGCTTGGATGTCCTGTCTTTGTCTTTTATTTACGAGTTCTTGGAGTGGGGTGCGATATCTTCTTCGTCGAGCGAGCTCGTCAACAAGAGCAGGCTTTACGTAAAGGGAGGAAAGTACTGGGCGCTCCTCCCCAACGAGATTGCTTTGCAAAGGCGCTCTTTGAATCGCGACAAGCTGGGAAGAAGATATTAGACCGTTACCTGATTGGATTTGAGCTAGAAACAGGAGCACCGCTTTGGGTATCGGACGATGATCTCTGCACTCATGCCGCTGTGTTTGCTAAAACTGGGGTTGGGAAAACATTGTGGCTCGAATCATTGCTGTTTCAACAAATGCTGCGCGGTCGTGCCAGTGGTTGTACTTTTATCGATGCGAAACGAGATTCTGGAACGTTAGCGCATATCATTTACATGGCACACATTACGGGACGCATCGAGGATTTGATCGTCATTGATCCACTCAGTCCCATTCATTCCTATAACTTCGTTGCGACCACTCAGCGAGCGGATGTGAAAGCACGTAAAGTGTTGCGAGCAGGGTTACCCCCCATTGCGGATGCGAGTACGGCGAAACACTATGATCGCTTAGCGGCTGACTCTGTGTTCCGCATTGTTCGTGCGCTGGATAGCATCGGCTTATCTTGGTCGATCAAAGATGTTGCGGTTGCGCTGAGTTCTTTTGCGATCGCCTATCCCTATCTTCATAACGTGCTGCAATCCGTGAATGCTCAAGAGGCACTGCTAGAACTGAGTCATTTTGCGACGACATACCGTACCGCAAAAGGGACATTGGATATTCAGAAACTCACCGATAATTTGCGAGGGATTGCTTCTGAACTGCACTCGATTGCAGCCGGAGATGCGGGAGATGTATTCTGTTCCACTCACTCGGATCTACGTTTGACCGAAGCAATCATGCAGGGAAAGATTGTGTATTTTATGCTGCCACGACTGGAGGAATCTGAAGGAGCATCACGGATGTTGAAGGTATTCCGCGAGGATCTTGAAGTGTCGATCGGTGAAATTACTTCAAATCAGGACTTTCGGTTGGATGACCCACATCTTGTGATTGTGGATGAAGGGGCATCTACCTTCTCTCCCACTTGGGCAAATCTGTTTGAATTAGCCAGAAAAGGAAGGTTTGCGTTGCTTTTTGGAGCGCAGTCCGCAGCAGGATTGAGTGATCAATCATTGGGACTAAGCCAAGCATTTTATGAACGGGTGATGGCGAATGTGAATCTGAAAGTTGCCATGCGATTGGGAGATAATAAAACGGCAATGGATCTCTCACATTGGTTGGGAAAGACAACCGTGATCAAAAAGTCTGTCAGTCGATCGAAGTCGAAAGGGAGTGCGAGCTCCGCACTGTTGTTCGATGCGAATGCGAAGCGGCAGACTGGGCGTTCTTCAACTGAGAGCTTCTACGAAGAAGAAGTGGATTCTGTTTCGGCTGATGAATTGAAGTATGGCTTACTCGCAGAGAAGGGACTGGCATGGGTCGATTTAGGCGGAAAGCTGACGAAGATGCGGGCTTTATGGATTGATTTTGACCTTCCCAAAGATTGGAAGGGGCGCAGTACAGTTCCTCAATTGGAAATCACTGAAACAGATCCGCTGGCTCTGGGCAAGATCGTCGATCGTGCCGTACTTGAATCTGAAATCATCAATCAACAACGGCAAACGAATGTTGCAAGTACAAGCATTGTGAGTTCGGTCTCCACTCCGACAAGAATTGAAGCATCGCGATCTAAACATCAAGAGACGTTTAAGTTATTGCATAACGATCAGCATCGGAGTTCTCGCTACGAGAGTAGTGTCGTTGTGCCAACGCACCTTCAGAGGCAAACGATGGTCGGTTCAGAGTCTCGTCCATCATTCTTTCGTCTGTCTTCAAAGAAAAGCCCTCGCAAGCGGTGATCTCTGGAAGTACAATTGTCTGCCGAGTTGCTGATTGAAGAGATGAATTTTACTGGATGGCAACTGAGCAAGATCTATCAGAGTTCCAAAATCTGATCTTGCCTGCAAGCGAGGTGCTTCCAGATCAAATATCAAATCAAAGGAGAATTTGTTCTTCAAGGTCTTGGGGCGATTGGCGGATGAACTGGATTAATCGATCGGCTTTAGAAAGACTCCGCATCTGTGCTAGAGGCTTCACTTCTAATCCCAGAGTTTGAATGATTTCATGTGCATAATGATTCGCGAATTTTTGAAAGATGTAACGTTTGGCGAGCGGAATTTTCTTTCCTTGTTGGTCTATTCGGTAGAGATGCTCATCTTTTTGCACATACGCTTCAAATCTTTGAGCAATATCGCCTTTCTTAAAGGTGGGCTTTTGCTCAAACTGCAAAACATTGTCCAGGGTGATTCCCTTAGATTTCAACTTTTTGATGAACAATGAGTAGAAATCATTTGGGGTTGTTTGTATTTGACGAGTTCTTTGACTTTCCATAGTTGCCCTGATTGCTTAGTCGATAAAGAGCGCCAAAAGTAACACAAAGTCATGATGGATTGCAATCGAAGCGTTTGAATTTGAATGCAGTTTGCTAAGACTGCCGAGCTTTCATATAAATCTTGCTACTCGGTTGTGGTTGAGGACACGACCTTGCCGTTTGAGTCCACCTCGCTCAAAGACGCTACTTTGCCCACTGCACAAACCCTTTGAGCTAACGATTCAGCGCATGTACGGGTGAATTGGACGAATGTACAGCTCTCTAATATCTGGCGATTCAATCTTTGGCAGAAGCAATCTCTTGGCTGCAGGTTCTTCAGGACTACAACGCATCGGGGCGGAAGATTGAATCGACGAGCTCCTCAATCGATTCTAGGTCTGAAGAATTCTGTAGCTCACCCTCAAACCATTTCACCTCTTCCGGCTCTGTCCCTGGCAGTTGATAGACCAGCAATACACCCGTCACTCGTGCTACTGTCAATGGGTCAGGAGCAAGATGGCTGAGCAGCCTTTGCGCTTTCTGATAGAGCTGTTGAATCGCTTCTGCATCTTGTGGGTGTTCAAGCTCAATTGACATCTGCTGTAGACTTTCCTGAACAGCTTGGACGAGTTCTGCATCTTCGGTAGGGTCGAGTGAATGAGACATCAGGCTTGGCAAGAATAACAGCGGGTTTCATCCATTTTAATGCTTTGCTAGCGTTCATGGGCTCGGCTTGGCACTACAATCAGAGCAATCCAGTTCGTGAGCCAGCCCCTATGTCCTCTGCAATGTTAAGCGATGAAACGAAACAACAACTCGAACAAGAGCGATCCCGCTTAGTGAACGATCGCCGCAAGATTGTGTCCGAAATCGAGTCCTCAGTCAGTGCTCAAGTCGATCGCACCCTTCAAGCTCTCAATGCGCTGCTTGATGTACTCGCGAAAGTCGAAGTGCCTGCTGTAGATGACATCGTTGAATCTGTGCCTGACATCCTAGAGCACGCGACGACTGAAGTCCCAACTCAATCTGTTCCTCGTCCTCGCAAAATAGGCACGAAGAGCACCGCAAAGCCGAAAGGGAAAGGAAAAACGAGTCAATCGCAAGCGTTTGATGCTAAGCACCTCAAGGGCAGCTTCAACGGCAAGAGTCTTCGTGATGCCATTCTCGAAGTGATGCAGCAAGATGCAGCACGAGTTTACGCAACTGATGAACTCATTGTAGCTCTGTACGACCCGTTCGAGGAAGCTGACCTGCCGATAGCCAGAAGAACGCTGGGAGCGACATTCATGCACCTGATTCGAGCGGGCAAAGCCGAGAAGGTTCAAGACAAGCCACCGCACTATAAACTCAGCCGTTAGGGGGCTGATGGAGGTGTATTAATGCTTTCAATTTCAGGGGTACTCGGTCCCTTGACCATCAAGATCACGCAACTGCCAAACGTGACGGTTGTGGAGAATGACTGGCGCAGTTTTACCATCGATATTGGGAGTGCAATTGTGAGTGTCACAGTCCGACCGAGGATCTGGAACAACTGGGTCGAAGGAACGAAACAGTACCAGAACTGGAGTGCGATTATCACGGGGAGAATGGGGGAATTGACGGACGTGGGGTTTGTGCTGGAGCAGCCTGGGATTCAAATCTTTGAGGCACCATCTGAACCTGTGGATTGAGCAATTGCTCGATCACACAGACTCACCTTGTAAGAAGGCAACGTTCTTCTAGAGTCACGATCGTCAGCAGTAAAATTCAGGTGTGCAAACGCTAAGGCACTGTCGCAGGGTTCTGTCGCAAAGATAATTAATAAAGTAACAAACGAGTTGGTCTAGTTCGTATTGTTTTAAGCAATCACTCCGAAGTTTTCTGCTCTCACGACAAATTCAACATCTGATAACGACCTGTTAAATTATCCACTTGATCTGTTCCAATCGCCGAGGGTTGCGTACTTAAACGGCTTACCTCCTTGACATACCCGCATCCTACAGTCATTGGCGGTAGATCATGTTGTTTCAAGACGCTTTCAATTCTTCTGAAAGCTTCAGGCAGTTGATCGAAGGGAATACTTGGAAAGGCATGATGAACAGAATGATAGTTCAATCCGCCCACAAGCCAACCGACGATCGGATGTACAGTCAGATTACGACTGCTGTAAAGCTGTGTCAGTTGATGTCCGGGTGCTTGGCTCCACATTCCGTAATGTTCAAGATGATCTCGTGCTTGAACGACCACGCCAATCACTCGCTCCAGAATGCACCAAAAGATAATGTATTGCCATAGATGCTGTGTAAACAGTGCCACGGTTAAAAAGCTTGCTTGAACCAGAACAATGCCGATCGCATCAAATAAAAGTGCTCGGCGAACTGCCGGAATCGTTTTACCAAACTGCCATCCATGGCGAATTGTTTTAGCAATCATGCCCAGTCCACCCAGCACGAACAGGTCAACTTGCCATTGATGCCGCACATACCACTTCATCCAAACACTCGCATTCTCATACTCTTCGAGTGTCCACTGGACTCGTTCTGGATCTTGCAAATTGGTACCATTCCAGCCATGATGCAGGCGGTGTATTTGTGCATAAACACTATGCATCCAAAGCATTGGGTAAGACATCAAGCGCGGCAGTGCCTCATCAAACCAGACCCAACCCGTGAGCGTATGATGAGTCGCATCGTGAGTGCAGATAAACCAGATTGCATACACAAATCCAGCGATCGCGCTATAACCGACAAAGCCCCACGAGGTTTGGGACAACCAAGCTAAAACTATCAAGCTCAAGCAAACAAATCCCAAAGTACAAAACCGCAGTAAACCTATCCAAGGATTGACTGTGTTTAGATCAGCAACGCTTGATCGTAGGTCATGCGTCACTTGCTTCAATTGCAAATTCTTCAACGGCAAATCATCGGTGCTCATAAATCACCTCCATCCCTCGGAGATGAATGGTACAAACAGTGGAACTTTTGGGGAGACGCTCTTTACACACCTTATCGCGATCGTTGGAGCGAGCTATAAAATCTTAAAATTTATTATTTCGATGTGCTGCACCATTTGTATCTTGGTTGTGTCGCAAAGATGATAAGGTAGGGAAGCTCAATTTTTCTTTAGCCTTGCCCTAAATGACGACCGACTCGCTGTTCAAATGGCATCACTTTCTGCCTGAAATTATCTTGCTGAACGTGCGCTGGTATTGTCGCTATTCTTTGAGCTACCGGAATTTAGAGGAAATGATGGCGGAAAGGGGTGTTGCAGTTGATCATTCCACCCTTAATCGCGCTCGTTTTGAAATTCGCCTCCAAACTCGACAAGCGCATTCGTCCGTTTCTGAATCCAACCAATGACTCATGACGGGTGGACGAAACTTACATCGAAATTCGAGGTGCGTGGAAATATCTATATCGAGCAGTGGATTCAGAGGGCAATACGCTGGACTTCATGCTGAGCGCGAAACGGTATGGTAAGGCAGCAGCGCGATTTTTCCGTAAAGTGTTGGCAGCCAAGCATACTCAAACTCCCCGAGTGATTACCGTGGATAAAAATGCCGCGTATCTAGTTGCGATGGATGAATTGAAGCAGGAGAAAACATTGAAAGCCGAGACCGAATTACGACAGAGCAAGTACTTGAACAACAGGATTGAGCGGGACCATCGGAATGTGAAACGGATTGTCAAACCGATGATGGGATTTCAATCATTCAACACGGTGAGAAGAACTCTTCGTGGGATTGAGGCAATGGCGATGATCCGCAAAGGACAGGTAAAGGGAATTAGTCGAGGGGATAGTGTATCTCAAGCAGCATTCATCAATGAGACCTTTGGAGTTACTGCTTAAGAAATACGAACGAGACCAGTTTGTTTGTCACTTTAAAAGCTTTGCGACAGAACCACGTGCTGGATGTCTTGCTGCAACGGCAACGAGACACAAAGGCAGCAGAGCGATTCTTCCGCAAATTGCTAAAGAAACAGGGCTTTGTGCTACGGGTGATGGTCACCGACACATTAAAGAGCTACGAAGCGGCAAAGAGACGAGTGATGCCGAGTGTAGAACATCGACAGCACAAGGGGTTAAATAATCGAGCGGAGAATTCGCATCAACCAACCAGAGTGCGAGAGCGACGAATGCGGCGATTCAAATCCCTAGGGCAAGCCCAACGATTTCTTTCTACGTTTGACCTAATTCGAGGACACTTTCATCCCAAGCAACATGAACTAAGTGCGAAACAATATCGAGAACAACTCTGCCACCGCTTTGAAGATTGGCGAGAAATCACTTGTCTGAAAGATGCTGCGTAAATTGAGCGAGACTAACAATTGGGGGATTATCGCGCTTAATTTTGAATATTCTCGATTAAGTTGACAGTGCCGTTTTTTCAAACATCCTCTAAAACAATACGAACGAGACCAATTCGTTTGTCACTTTAAGACCTTTGCAACAGTGCCACAAGGCGAATATGTTCTTCATGATAATGCCAAAGATAAAAACAGCAGAGAACAAATTTTGCAGTTCTACCACTAGATAGATAGTTACATACCCCTGAAGTAGGATAATCGGTTACAGCGCATTTTACGCTCCCAAATCTACTGATGTAAGACCCGTATCTATGTTAGAAGCATCTGGTCTAAAATTCGCCCAAATCAATTCTTCAATATCAGCCTGGAGTTAGAAGGACGATGGGCAAGAAAAATTCAAGATGGTTAAGGAATGCTCAAACGCGGCAGAATGGTTCACCATCTTACATTGCACAATATGGTGTGGCGATCGTTTCTGTTACTTTGGCGTTAGGAATCATCCTTGCACTTAATGCTTATCTCGCATCAACACCGTCTCCTCTCTTTTTTGCTGCTGTCATGCTGAGTGCATGGTATGGTGGGTTAGATTCAGGAATCCCTGCAACAGTCTTTCCTACGCTTGTCATCAACTTTTTCCTGGTTGAGCCGATTTACGAGCTTGGTATGCCTGATTTGGGGACTTTTGCGCGCCTCGGTCCTTTCGTGATGACAGCGCTTTTCATTAATTCATTAACCGAAGCCCAGCGAGCTGCTCGTCATAAAGCAGAAATAAAGTTCAAGTCTCTACAGGAAAGTGAAGCCCAATTTGGCTGTTTAGCAGGATCTAACATCATTAGAACGTTAGTCGCCAGAATAGATGGCGTAATCCTTGACGCGAACCAAAACTTTCTACAGCTTGTGGGCTCCAGCCAAGAGGAATTGCATACTGGTCGATTAGATTGGCGCATGATCACACCTCCTGAATCTGTGGGGGGCAGTGAAAGAGCAGTCGCTCAACTACTGTTAACGGGAGGCTGTACCCCGCTTGAGAAGGAGTACCCCCGTAAAGATGGGTTTCGTGTTCCTGTCCTGCATGGTGCAGTGATGACTGGAGACGTAACGGTTACAGATTTTGTGCTGGATTTGAGCGAACACAAACGAGTGACCGCGATTCAACAAGAAGCCATGCGCCGAGAGCATTTGCTGCTTGCACCTCAGCGAGCAGCAAATGCTCAGCTTGAAACGGTGCTAGCCAGTATTAACGATCAATTTCTGGTTCTAGTACTACAGTTGTAGATCTATCGTGATAAGTCTTGGGAATATATAGCCTGACGGCGTTTGTAGTGATGGAACTGTGCCACTGTTTGATGCTGTTGTCGCCACATCGACCAATGCAATCGAAACAACATCGACTGTTTGAGTTCCCAACCTAAATGCCAGATCAAGCGGCGAATCTCAGCAATTGAGTTTGGAATTACAGACCACGCTTGCGCTTGAATGCGGAGAACTGACGCGATAGATGCCCCCCTTTTTCTAATTCAGATGCATGTGAGCGGACTATCGTCAAAAACGCATGAGCGAGGCAAGATAAGGTGATATGACGATACCAGCCTTGCCAAGTTCTGACCTCATACTGGTCGAAGCCGACTTCCCCTTTGGCAGTTTGAAAGCACATTTCGATTGTCCAGCGCGTGCCTGCGATCTTGACGACGGCTTCGAGGGGAGTTTCCGTCGGAACAAATGCTAAGAAGTAGGCAACTTCATTGGGTTGGTCAACAGAACGGCGTGCCACCACCCAACGCTGCCAGTTTGGTCGCTCAGGATGCGGGATAGCAATCGCTGTCCAATCGAACCAGCGTTGTCCTTTTGCACCGCTGCCTGCACTCAGGCGTGACCAATCACTGGAGTCAAGTTCAGCAATAACTTGGTCAATCCGCTGTTTTTCCCACTTGAAACTGACCGAGTGATCACACGCGACCTCCAGCACATAGCGCACCTGATGTTGTTCCAACAAATCGCGCAAGTGGTAGTCACTGCCATACACACTATCCCCTGTCACCCAGCCCACGGGCACTTGTGCTTCAAACGTTCGCTCCAGCATCATACGTGCCAGTTTTGGCTTGGTAGCAAACTTGCGCTCCACGGGGATATGCGCCGCTCGACAACGTGCCGCGTCGTCTGTCCAACTTTTCGGCAAGTACAATTCTCGGTCAAGAAATGTATGTCCTTGACGAGTTGCATAGACTAGGAACACGCCAATCTGACAGTTCTCGACTCGTCCTGCGGTTCCAGAGTACTGCCGCTGTACCCCAACGGAATGCTTGCCTTTTTTGAGAAATCCGGTTTCATCAATCACAAGCACAGCTTCACGATCTCCCATCTGTTCCACCACATAGCTGCGAACATCATCCCGCAACTCATCTGCACTCCATTTTGACCGATTCAACAGATGTTGGATGCCATAAGGTGTCTCATCGCCACATTGCTCTGACAACTGCCAACCGTTCTTGCGCTCAATTGGACTCAGCAACCCTTGAACGTACTCCTGCATCCGTTGTCTGGCTTCGACTCGTCCGAACTGATACCCGACTCGCGCAATCAGTGCATCGAATTCACGCAGCCATGTCTGCACCTCAGTCCTCATTTGTAGCAATGCACCTGGATGACTCAGCATCGACCACCAGCCCCAAAATGTTCACGACATTTCTAGGGTTCCCAATATCTACAACTGTAGTACTAGATCAGCAGTCGCGTTATGTTTACGTCAACGATCGAGTGATAAAAGTTGTGGGCCGATCTAAAGAAGAACTCATAGGTCAATGTATTTGGGATCTCTTTCCAGATCTCGTTGATAGCCAGTTTTATACTAAGGTGCATCGAGCCGCAGCAGAGCAGCGAAATCTTCAATTTGAATACTTTTATGCCCCCTGGCATCGGTGGTTTGAGAACCATATTTATCCGTCTACCACCGGAGTTCCAATTCTTGTCACTGATATTACAGAACGCAAACGAGCAGAAGAAGAACTGCAATGCACAAATCAAACGCTACAAACCCTACTCGATTTCTGTCCCGTTGCGATCGCATTTTTTGATTCAGAGAGAACTATTAAATTGTGGAATCGTGCAGCAGAGCAAATTTTTGGCTGGAGTGCCGAGGAGACTGTTGGCATAAATTGGCCAACAGTCCCTCATCGACAAGCGGAGTTTCTTGCCAGTCTTCAAACCGTGTTGAGTGGGCAATCCCTCAATGGATATGAAGCTCAGCATAAGCGGAAAAATGGACAGAGGGTGGATTTGGAAATCTGGGCGAATTTAACCCATGATGCAGAGGGAAGCCCCGGTTGCCTGGGAATTGCGTTAGACATTACCGAACGCAAGCAAGCAGAAGCAGCGCTCCGTCACAGTGAAGACCGATTTCAGGTACTGGTCAGCAATATGCCGGGCATGGTTTATCGTTATGCTCCCTGTGCAAATGGCAATGCTGCTTCTACCAAAGCTAAGTTTACTTATGTCAGCTCAGGTTCACGTGCATTGGTTGAACTAGAGCCTGAAGCAATTCTTCAGGATGCAAACGACTTCCTGCAATTGATTCATCCCGACGATAAATCGTCTTTTCAAAATTCTGCTGACGTAGCTGTTCAAAACTCTGCACCTTGGCGTTGGGAAGGACGGCTAATTACACCCTCTGGGCAGCACAAATGGGTGCAGGGACGTTCGCGTCCTCAGTATACCGAGCAGAGAGAAGTTTGGGATAGGCTGTTTTTTGATATTACCGATCATAAGCGAGCCGAAGCGGAACGGTTACAACTTCTAGAACAAGAACGCGAAGCGAGAGAACAAGCAGAAGCTGCAAACCAGATTAAAGATGAGTTTTTGGCAGTCTTGTCTCATGAACTCCGAACACCCCTCAATCCAATTTTGGGCTGGTCGCGTTTGCTTCGGCAAGGAATACTCGACAACAGTAGGACAACCACAGCCTTGGAAACCATTGAACGGAACGCCAAACTGCAAATTCAACTGATTGATGACCTGCTTGATATTTCTCGCATTTTGCAAGGCAAGCTTAGCCTGAAATCTGTCCCGGTGGAGTTGAACGCAACGATCGCAACTGCGATCGAAACGGTTCGACTTGCTGCTGAAGCAAAAGCGATTAGCATTCAAATCCAGTTTGAGTGCAAAGCTATGACGGTTCTAGGAGATAGTGGTCGGTTACAGCAAGTGACTTGGAACCTACTGACCAATTCAGTGAAATTTACGCCTGCAACCGGACAAATTCAAATTCGGCTGTCAACAACGCAGTTTCAGGCTCAGATTCAAGTCACGGATACTGGCAAGGGCATCCATCCAGACTTCCTCCCTCATGTCTTTGAATACTTTCGGCAGGCAGACAGCACCACAACTCGAACTTTTGGTGGGTTAGGATTGGGACTCGCAATTGTGCGGCATCTTGTAGAGTTACATGGCGGTCAGATTAGAGCAGAAAGTTCTGGAGAAGGGCAAGGCGCAACTTTTACGGTAACGCTTCCCCGGATGCCCTCATCCCCTTCAATTTTAGAGGAGGCACTACCGATGAGTGATCTGAATCTACAAGGCGCTAATGTTTTGGTGGTTGATGATGAAGTTGATAATCTTGAACTCGTTCAATTTATCTTAGAGCAAGCAGGCGCAACGATAATAGCTGCATCTTTGGCAACCGAAGCACTAGATCAAGTCCGTCAGTTAAAACCACACTTGATTGTTGCAGATATTGGGATGCCGGAGGTAGATGGTTATACGCTGATACAGCAAGTCCGAAAACTTCTTCCCGAGGAGGGTGAACAAATTCCAGCCATTGCACTAGCGGCTTATGCTAGCGAGGTGAATCAACAACAAGCTTTAGCCGTTGGGTTTCAGCGGCATCTTGCCAAGCCTGTCGATCCAGACGCGTTAGTGCAAGCGATCTCTGAATTACTCCATCAGACCTAGTGCATCCAAAGATTTTTGACGCTTTTCTGCTTTATTACTCAACCTCCTGAATTTCTTAGTGACAATGAATGACCCTAGCATCCGTACAAATCCCCATCTTGACGAAGTCAATGCACTTCGCCAACGCCTGCGAGATTTGGAGCAGTCTCACAACCAGTGTCAGCAGCAACTTCAGCAACTCCAGCAACAGTTGAGCCGAGAAAGAACAGAGCGAAAGCAAACTGAAGCGGCACTGCGGGGAAGTGAAGAGCGGTTAAGTGTGGCGAATGAACGCTTTCAACTCGCAGCAAAAGCCGTCAATTGCTTGATCTATGATTGGGATCTAGAACGGGATCGAGTCGAACGAACCGATGGATTAACCCGGATTTTGGGGTATTCGCTGGAAGAAGCTGAACCCACGGGTCAATGGTGGCGAGATCGCGTTCACCCCAGTGATTTATCACGTATTCAAGAACAAGCCCTGGTGACGTTGACTACGCACGATTATTTTGCTGCTGAATATCGAGTTCTCAACAAGTCGAATCAGTACATTGATGTCTTGGATCAGGGTTTAGTCGTAGTGCGAGACTCGGATGGTAATCCCACACGAATCGTAGGAAGTACCACGAATATTAGCGATCGAAAACAGGCTGAACGGCAACTTCAGGAAAGCCAACGATTCATTCAGCAGATCGCCGATGCAACACCGGGAACCCTTTATGTTTATGACATGCTCGAGCAGTGCAATGTCTATGTCAATCGCCAGATTGGTGAACTGTTGGGCTATACTCCCGAGGACATCCAGAGGTTAGGGGATCAGCTATTTCCGCAACTGATGCATCCTGAAGATTTTGCGAATCTTGGTCTTCAGATTCAACGATTGGATCAAGCGCAAGATGACGAGATTGTCGATCACGAGTATCGGATGCGCCATGCTAATGGGGAGTGGCGTTGGCTATGGAGCCGGAATACTGTTTCGACCCGATTGTCCGATGGACGAGCGCATCAAGTCGTCGGTACCGTGTATGACATTACTGCCCGTAAGCAAGCAGAAGCAGAATTGCTCAACCGAGAACAGGAGTTTCGGACGCTCGTTGAAAATACGCCAGATATCGTCATTCGCTACGATCGTGACCTCCGCCATCTCTACATTAACCCTAGTGTTGAGCGGGCATTGGGGATTCCACCAGAACAATTCATTGGTAAAACAGGTTTTGAACTGGGCTTTACAGATGAGAGATCGCAACGCTGGTACGCCATCTTACAGCAGGTCTTTGAAACAGGGCAGCGTCAGTCGATCGAATATGAGTTTCCCAATTCATGCAACGAGTTGCGTTCGTACCGAGTTCGTTTTGTCCCTGAATTAATTCAGGGAGGGCAAGTCACAACCGTTCTCGCAGTTGCTACGGATGTAACAGAATACAAACGGGCAGAGCTATCCCTGCGCCAGAGCGAAGAACGGGTGCGATTAGCCATGGAAGGTGCTCAAATGGGCACCTGGGACGTAGACTTGAACACTGGAAAAGCCATCTGGTCAGTCCAACATTTCACGATGCTGGGTTATGAACCTGTAGCAACGGGGGAAGCCAGTGAGGACATGTGGAGTAGCCATATTTACCCGGACGATCGAGAACGAGTGTTAGCAGAATGGCAACGAGCACGTGAGGAACAACGGCTCTACCGTGCTGAATATCGCATCATCCGAGCAGATAATCAGCAGATCAGGTGGTTAGCCGCACTAGGAAGTTTTACTTACGATACGAATGGCTTGCCCATTCGTTCTATTGGCGTTTTGTTTGATATTAGCGATCGCAAACAGGTAGAAGCTGACCGAGAGCAACTATTGCACGAACTGTCAACCGAACGCGCTCAATTTGAAGCAGTGCTACGGCAAATGCCTGCGGGTGTCATCATTGCCCATGCTCCTTCCGGTAAATTGATCTTGGGAAATCAGCAAGTTGAACAGATCTGGCGGCAACCGTTTCTCTCTGCCAATAATATTAATGAATACGGTGTATATCAGGGCTTCCACCCCGATGGAAAATTGTATCAACCCGAAGAATGGCCCTTAGCACGTTCTCTGATGACTGGTGAGATTGTTGATCAAGAGGAGATTCGCTTTGTTCGGGGAGATGGACTTAAAGGTGTGATCAATGTGAGTTCAACGCCTGTCTACAACTCCCACAGAGAGATTATTGCTGGGGTTGTGATTTTTCAAGATGTGACCAGCCGTAAGCAAGCAGAAGAATCTTTACGGCAGAGTGAAGAACGGTTGCGTCTCGCATTATTAGTGGGTCAATCAGGGATTTGGGATTGGGATATTGCCCATAATCACATCACATGGTCTGAGCAAATCTATCAGTTTCACGGCTTAACATCCGAAACCTTTAGCGGCAAAGTCGAGGATTTTGCCGAGTTGATTCATCCCGAGGATCAGGCAAAAGTGTCAAAAGCGATCGATCAGGCTCTAAGGGAGCGATCAGGCTATGAAATGGAATTTCGGGCTGTCCATCCCACTGGTGAAATTCGCTGGCTCTCGACCAGAGGCGGCGTGATTTTTGATCAACAAGGCAGCCCAGCGCGAATGTTGGGTGCAACAATTGATATCACAGAGCGCAAAGCCATCGAGGTAGAACGTGAACAACTCCTGAGGCGAGAACAGATTGCCCGTGAGCAGGCAGAAGTCGCGAACCGCATTAAAGATGAATTTCTCGCAGTGCTGTCCCATGAATTAAGAACGCCACTCAATCCGATTTTAGGCTGGACAAGACTGTTACGGACTCACAATTTTGATCCCCAAGCAACCGATCGCGCTCTAGAAACAATCGAGCGCAATGCCAAACTTCAGGCTCAACTCATCGAAGACTTGCTCGATGTCTCTCGGATTTTGCAAGGCAAACTGAGATTGAATTCTTTTCCTGTGAACTTAGTGACGACGATCGAAGCCGCCCTCGAAACCGTACGATTATCCGCTGAAGCAAAAAGTATTCAAATCCAAACAATCTTGCACTTAGAGGTTGGGCAAGTCAACGGGGATGCGAATCGTCTCCAACAAGTGGTGTGGAATTTGCTCTCGAATGCGATCAAGTTCACACCGTCTGGTGGTCGTATCGAGGTTCGACTCACGCAGAGCGAAGCCTACGCTCAGATTCAGGTCAGCGACAACGGGCAGGGGATTCGTCCGGATTTCCTACCTCATGTGTTTGAGTATTTTTGTCAGGCGGATAGTAGTACGACTCGACAGTTTGGTGGATTGGGATTAGGACTTGCGATCGTCCGTCATCTTGTGGAACTGCATGGCGGCAGGGTGAAAGCCGAAAGCCCAGGGTGCGAGATGGGAGCGACTTTCACCGTTGAACTGCCGCTGATGGTATCGGCATTAACGCCTGATTTAGCAGTTGCGCCGAGTCAAGAAACCAAGAATCTGAAAAGTGTTCGCATCCTGATTGTGGATGACGAAGCAGATATGCGGGATTTGATTCGTTTCATTCTAGAAGATCAAGGAGCAACGGTTCGGGTGGCAGCATCCGCAGCGGAGGCATTACAACAGTTCACCGAATCAATGCCAGATGTGTTAATTAGCGATATCGGCATGCCCAACATGGATGGTTATGCGTTAATAGCGCAGATCCGAACAGTTTTATCAAAGCAAGGGAAAACTGTTCCGGCAATTGCACTGACTGCCTATGCTGGAGAGGTCAATCAGCGCCAAGCTCTAGCGGCTGGATTTCAACTTCACCTTGCTAAACCCGTCGATCCAGAGCAGTTAGTAAAGTGCGTCTCGCAGGCTATAGGTTCATCCTTTAAACCTTCTTCTTAGTAAAGGCTAAGAAGAATTCACAAGGGTTTTATTATTCACAATCGCGATGGCAAGGGAGCAATTAGAGTGGCACTTTCATTATCCGGATTCACAATTACTGATTTACTCCAAGAAGGAACAAAATCGCTGATCTACCGGGGCGTGAGAGATGCGGATGGTTGCTCTGTCGTGATTAAAGGGTTGCGTCCAGAAGTCTGTACTGCTCGCAATGTTGAACAACTCAAGCATGAATATACAATTGCACAACAGCTTAATTTACCGGGAACTGTGCAGGCGTTGGACTTAGAGTTCGATCGAGGATTGCCCTATCTAATTTTGGAAGACTTTGGAGGTCGATCTCTCGATCAACTTTTGGGTCAATTTCGTGAACCTGCTGCCTTTCTCAACATTGCACTTCAAATTGTGGATGCACTGGCACAAATTCACCAGCGTCACATTGTTCACAAAGACATCAAACCGCAAAATATCATCGTTAACTTAGACTGCAATCAGATTAAAATTGGCGATTTTGGCTTAGCAGCCTTTCTCCCCTACGAAAGTCAGATTGTGAGCCATTCCAATCGGATCGAAGGCAGTCTGCCCTACTTGTCACCAGAACAAACCGGACGGATGAATCGCGGCATTGACCAGCGCAGCGATTTGTATGCTTTGGGCGTAACCTTCTACGAAATGCTAACTGGGCAATTGCCGTTTCAAGGTGCTGATCCCTTGGAGTGGATTCACTGCCATATTGCCAAAACGTCAATTTCTCCGACTGTCGTTAATCCAGCTATTCCTCAAATACTCTCTGAGATTATCTTGAAGTTGCTAGCAAAGGTAGCAGAAGAGCGATACCAAAGTGCAATTGGCTTACAGGCAGATCTAGAGCGTTGCTTGCAGTTATGGGAAACAGCGAGGCAGCTTTCATCATTTACGATCGCCGAACACGATATCTCTGATCGCCTCCAGATTCCCCAAAAACTATATGGACGCGAGCCAGAAATCACCCAACTGCTAACCGTGTTTGAGCAAGTTGTGACTACAGGAAAGCCAGAACTGATTCTAGTATCTGGTTATTCTGGAGTCGGCAAATCTTCATTGGTGAATGAATTGCATAAGCCGATCGTACAAACGCAAGGCATCTTTATCTCTGGCAAGTTTGATCAATATAAACGCAATATTCCTTACAGTACGATTGTCCAGGCATTTCAAGGATTAGTGCGCCAACTTCTGACAGAGCCAGAAGAAAAGTTAGTGATTTGGCGCGATCGTATTCAATCAGCCGTTGGTAAAAATGGCAAGCTGATTACTGATGTCATTCCAGAAGTAGAGTTAATTATCGGAGAGCAGCCTCCTATTCCAGTGTTAGGCGCAGCAGAAACGCAGAACCGTTTTAACCTAGTCTTTCAAAACTTTATCGGAGCCTTCGCGCAATCTGATCATCCGCTAGCCATCTTTCTGGATGATATGCAATGGGCAGACAGCGCTACCCTCAATCTCATTCAAACGCTCATAACAGGTGCGACTCTGCGATTCCTTTGCTTTTTGCTTGCCTATCGAGACAATGAAGTTGATATCTCTCATCCCTTTAGTTTGATGGTAGAGAAACTACGTCAACAGGAAATTCCATTGACAGAAATTGTATTGGCACCCCTGGATCTGAGTTGTGTTAGCCAACTGATTGCAGAAACGTTACGATGTTCACTAGAACAATCGGAACCACTAGCGCAATTGGTATTGCACAAGACAAATGGTAATCCTTTTTTTGTGAATGAATTTCTCAAAACCTTATGTCAGGAAAACCTACTAACCTTCAATGCGGTTGAAAAAGTTTGGCAATGGGACATTAAACAGATTGAGGCAAAAGGGTTTACCGATAATGTGGTCAATCTCATGATCGAGAAGATGCAGAAACTGCGACCAAAGACTCAACAGCTTCTAAAACTTGCCTCTTGTATCGGGAATCGATTTGATTTAGAAATTTTAGCGATCGTTGCCCAGCAAGCTACTCATACCGTCGCAGATGCCATGCGAGAAGCTGTTTTACGGGGTTTAATCCTTGGAGAGGAGCAAACCGAAGCGGCTGAAGAGTATTACTCTTTTGCTCACGATCGCATTCAGCAGGCAGCTTATGCACTGATTCCCGATGCTGAAAAACAATTAGTTCATCTTCAGATCGGACGATTACTTCTGAAGCACTTGAAATCAGAGCAACTGGAAGACCAGCTATTCGATGTTGTGAATCATCTCAATTTGGGTCAAGAACTCATCATTGAGCAGGCTGAAAAACATCAACTGATGCAATTCAACGTTCTGGCTGGTAAACGAGCAAAGGCCTCTACTGCCTATGTTCCAGCACTGAGATTTTTTGACACTGCTAGCCGTTTATTGCCGTCCGATGCTTGGAAGTCCGACTATGATCAAGTGTTCAATCTCTTTACTGAACTTGCAGAATGTGAGTATTTAACCGGAAATTTAGAGCGAGCAGAATCCTTGTTCCAGTTGCTTCTCGACAAAGCTCAAACCGCTTTAGATCAGACAACGATTTATATGCTGCAAATTAGGCTTTACCAAGTTGCAGGGCGGTTTGATGAAGCTTTTAATCTTGGATTGGCTGCTCTTCGACTGTTTGGAGTGGTGTTTCCCGAAACGGATGAGCAGGTAGAGGCAGCCGTGAGTTGGGAAAGACAGCAAGCGGTTGAAAACCTTGGCGATCGTCAAATTGCCGATCTGATTCATGCTCCCATTCTTGAAGATCCGACCCTAAAAACGATCATCAGTCTTCTCACCTCAATGGGTCCTCCTGCATACCTCAGCAAGCCCAATCTCTTTCCCCTAGTTGTTCTCAAAGCCCTTAACTACTCATTAAAGTTTGGCAATACAGAAGAATCTTGTTTTGCTTACAGTATGTATTCGATGCTGTTAGTGTCGATGTTTCGCGATATTCCATCGGGTTATGCTTTTTCCGAAATGACAATCCGGTTGAATCAGAAGTTAAATGATCCAAAGTACAAAGGCACGGTTCTTCACATTCATGGCAGCCACATCAATGTTTGGTGCCACCCCATGACAACAGATTTGCCATTTTTAGAACAAGGATTCCTTGGCTGTGTGGAAGCAGGTGATATCACAATGGCAAATTACAATGGCTTCCAAGGTTCCTGGCAGATGCTCGAAGCCATTACGCCACTAGCAGATGCCGATCGCGCCATTCAAAAATATCTTGCCTTTGCCCAACAGTCGAAGCATGAAGCAGCTTACCAAACCATCCGCTTGCAGCAGCAATTTATCCTCAATTTGCAGGGACAAACGCGCCATTGTCAGACACTCAATGATGATGAATTCAATGAAGCGAAAGCGTTGGCGATTCTGCAACAAACAGAATTTGCGAGTGGTATTGTTTTCTATCACGTCATCAAGCTGATTGTCCTTTTTACTTATGAGCAATATCCAGAAGCACTCCAATCCGCTCAAAAAGCATTCGGGATTTTAGGAGCGGTACGGTCTCTACCTATTGAAGCCAATTATCTATTGCATCATGCGCTGGTTTTAGCTGCACTTTACCCTCATGAATCTAGGGAAATCCAAGCTAAGTTTTTGGAAACCTTGCACCAGCATCAGCAGCAACTTCGATATTGGGCAGACCACTGTTCTGCTAACTTTTTACACAAAGCAGTGTTAGTTGCGGCTGAAATTGCTCGGATTGAAGGACGTGATTTAGAAGCAATGCGTCTGTATGAGCAATCGATTAAATCTGCCTATGAGTATGAGTTCGTGCAATATGAAGCATTGGCATATGAACTAGCAGCAAAGTTTTACCTGAATCGAGAATTTGAAGCAATTGCCAAAACCTATTTACAAGAAGCGAGAAACGCTTATCTGCGCTGGGGAGCCTTGGGTAAAGTGCAGCATCTTGAAATCCACTATCCAGCTTTGCTTCCCCAACTCCAACCTGTTTCTCCCAAAAATCCTGCTGCTTCCTCTAGCACAACGTTTGTAAGCAGCAAGGAACAGCTTGACATCCTATCAGTAATAAAGGCATCACAAACGATTTCCAGCGAAATTGTACTGGCTGACCTGTTGAAAACCTTGATGCAAATCGCGATTGAACAAGCAGGAGCCGAGGTTGGGTATATCCTGCTGTCTCGACACGATCGATTAGTGATTGAAGTTGAAGCTAAAGCAAATCAAACCCAGGAGCAACTTAAAATTCAGCAATTGATTGCAGATGCTGAAACCTCCCTGTCGGTTCCTCAATCAATTCTCAACTATGTGCAACGAACCCAAGAAGTCGTCATCTTAGACAATGCTGTAGCCTCTGATTTATTTTCGGAAGATCGATATATTATTCAGAATCAACCTAAATCGATCCTCTGCTTGCCTATTGTTCACAAGACCAAACTGATTGCGATTCTATATTTGGAAAATAATTTAGCAACTGGAGCCTTTACACAGACCCAACTTTCCGCTTTGGAGATTCTGTCTGCCCAAATTGCAATTTCCTTAGAGAATGCTCAACTGTACAAAGACATTGCTGAAAGCCAAGAACAACTGAATCTAGCATTGCAGTCAGGACAAATCGGGGTTTGGAGTTGGGACATTGTCAACGACCAGGTAGAATGGGATGACCAGATGTATCAAGCGTTTGGAGTCAGCCCTCAAACATTTGACCATACGTTAGAATCTGTGATCAATTGTATTCACCCTGACGATCGCGACAATTTTACTCAAGCTCTAAGTCAAACTCTCGGTGAGGGCGTAGAACATAATCTAGAATATCGGGTTGTTTTTCCAGATGGCACAATTCACGATATTGCAGCGAGAGGTCGTCCCTTTTTCAACAAAATGGGTGAGCCGATTCTTTTGAGAGGAATTGTTCTCGATATTACTGATCGCAAACGATTAGAAGAACAACGGTTACAGCTATTGCGAGAACAAACGGCACGGGCTGAGGCAGAATCTGCAAATCGAATTAAAGATGAGTTTTTAGCGGTGCTGTCCCATGAATTGCGATCGCCGCTCAACCCTATTCTAGGCTGGGCAAAGTTGTTACGAACTCAAAAACTGAGTGAATCAAAAACTGCCCAGGCTTTGGAGACGATCGAGCGCAATGCTAAACTGCAATCGGAACTAATCGAAGACCTGCTAGATGTCTCGCGAATTCTACAAGGAAAACTTAGCCTCAATACAGTGCCGGTGAATCTATCCACTATGATTCAAGCCGCGATTGAGACCGTGCAATTAGCAGCAGAGGCTAAATCTATTGCCATTGAGGTGACTCTCGAACCTCAGATTAGTCAGGTACTGGGTGACTCCAATCGCTTACAGCAGGTGGTATGGAACCTCCTTTCCAATGCTGTGAAATTTACGCCCGCTGGTGGAAAGGTTGAAGTCCGACTAGAAAGCAATGAGGGTGATCACACAGAAGATTCGTCCTCTTTCACTCGTTACGCTCAAATCACGGTGACGGATACTGGCAGGGGCATCCATCCAGACTTCCTACCCCATGTGTTTGAATGCTTTCGTCAGGCAGATAGTGCAACAACTCGAAAATTTAGCGGATTAGGATTGGGACTGGCGATCGTCCGTCATCTTGTGGAACTGCATGGGGGCATAGTCCAAGCAGACAGCCCGGGAGAAGGGCTAGGTGCAACCTTTACAGTGAGGCTTCCACTGATGGCTACTCCATTGATACCGAAGGGGGAGACTCAACCTTCGATCGCTGCTAACCTGAATGGGCTTCAGATTCTGGTAGTAGATGATGACACAGACACGCGGGAGTTTGTTGCCTTTGTTTTAGAGCAAGCAGGTGCAAGCATTCTAACTGCTGCCTCAGCATCTGAAGCTTTCACAACACTCATGCAATCCCAGCCACATCTCTTACTCAGTGATATAGGAATGCCGGACATCGATGGCTATATGCTGATTCGTCAGATTCGCGCCTTGCCACCAGAGCAGGGCAGTACTATCCCAGCGATCGCGCTTACGGCTTTTGCTGGAGAAATGAATCAACAACAAGCGCTAGCAGCTGGATTTCAAAAGCATCTCTCGAAACCGATTGAACCGGATCGCCTGATCTCCACGATCGCGAGCCTAGTCGTTCGTTAAATGATTGCTTAGATTGAATTGATAGAAGTATACTCCTATGGAACTTAACTCGGCTAACCTCAAAGGCGATCTCTCCCAGCCTCCAGAACTAAGCGACCGCAAGGAAGAAGCGACCTTGCGAAAAAAACAAATTGAAGAAGCTCTGTGGGAAAGGGAAGCGCAATTAACGAGCATTTTTCAGACAATTCCCAATGGAATTGTTATTCTTGACCAGACAGGACAGATTGTTAGCGCCAATCCTGCCGCAGAACAGATTTTAAGGCTCACTCGTAGTAACCTGACTGAACGGGTGTACAATGACCCCGCTTGGTCTATTACAACGGTAGATGGACAACTCTTTCCCGAAGAAGATTTGCCGTTTGTGCAGGTGATGCGAACCGGAAAGCCAATTTATCAAGTCGAGCATGCGATTGCTCATTCCGATGGCACCATCATTATCTTGTCGATCAACGCTTCTCCATTGTTCAATGCCGAAGGAAGGATCACCAATGTGATTGCTGCGATCACCGACATTACAGAGCGTAAGCAAGCAGATGCAATTCTACGAGAATCAGAAGAACGCTATCGTTCGGTGATTGAAACAGCAGCCGAAGGTATTGTGTTTCAGCATAGGGATAGTCGGATCACGACCTGTAATGCCAGCGCTGAGAGAATCTTAGGTCTAACCGCCGATCAGATGATGGGGCGTTCTTCCCTTGATCCGCGCTGGTGTGCGATCTACGAGGATGGTTCTCCGTTCCCCGGCAAACTACATCCAGCCATGATCACGCTGCAAACGGGAGAGCCTCAGTCGAACGTCATCATGGGGATTTGCAAGCCCGATGATACCTTGACCTGGATCTCAATCAATGCACGACCCCTATTTCAAGCCAACGACACAGAGCCCTATGCCGTAGTGTGTTCCTTTTTTGATATCACCGATCGCAAAGCAGCCGAAGCAGAGCGTTTCATTTCGGAAATTGCTCTACAACAAATGCCTGATGCCATTCTATTAAGTGACTTAGAAGGCAGGATTCAACGCTGGCTCGGTAATGCTGAGCAGATTTTTGGCTACAGCGCAACAGAAGCAATGGGTCAGCCGATCAATTTTATTTATCACCCTGATGTTCGAGCAGCGATGACCACTGAAATAATGCAGTCTGTTCAAGAGACGGATGAATTTAGTCGTGAAATTTTATGTATGCGAAAAGATGGCTCAGAAGTGCCGATCGAAACCACCATCAAAACCGTGTGTGACAAAGCCGGGAAGCCGCTGTTTCTGATTGGAATTAATAAGGACATTACAGAACGCAAGCGGGCAGAAATCGAACGAATTCAACTGTTGCGGCAACAAATTCAAGAACAAACTGCCCGTTTAGAAGTAGAGGCAGGTTTACGACGATCGACCTTCCTTGTAGAAGCGGGTACCTTACTCGCATCATCCCTGGATTACGAACAAACACTCCAGAGTGTTGCTAGTTTAGCGGTTCCCTACTTCGCAGATTGGTGCGGGGTTGATTTACTAAATCATGACGGGTCTATTAGCCGTGTTGCCGTTGCCCATGCAGATCCGAACAAGGTGAAGTTTGCGTGGGAGGTCGCACAACGCTTTCCCAGACACTTAGAGGATGGCTATGGGATCTCTCAAGTGATGAAAACGGGGCACAGTGAAATTGCGATCAAGATTACGGATGAGCAACTCACAGCCACTGTCCCAATTCCGGAGTATTTGGAAATCATCCAAGAGTTGGGCTTGAAGTCCTGCATCATCACTCCATTGCAAGCACGTGGACGAGTGGTAGGCACGCTTTCCCTTGTGTTTGCTGAATCAAATCGCCAGTACAGTATGGCAGATCTAGATCTGGCTGAAGATTTAGCGCGTCGTGCCGCGATCGCCATTGATAATGCTCGTCTTTATCACAGGACTCAACAGGCAAAGCAAGACGCACTTTCAGCTGCCAATCGTATTACCCGTCTGCAAAGAGTGACAGCCGCACTTTCAGAATCCCTCACACCTGAACAAGTGATAGAGGTTGTCGTCGAACAGAGTGTAGCAGTTCTAAAGGCAGCGGCAGTACTGGTGGTTTTAGTCAGTAAAGATAGAACAGAACTTGAGATTGTAAAATCGATCGGCTATGAAGCAGACTTAGTACAAAGTTGGTGCAAGTTTCCGATCAACACAGATGTTCCCCTAGCAGAAGCTGTCAGAACCGGACAGCCCGTTTGGGTGGAAACGCTGTTAGAGCGAATTGCTCGCTATCCCCATCTCGCTGAGATTTACAGTCGGTATGATTTTCAATCCTGGATTGCACTTCCCTTAGTGGTTGAAGGCAAGTCAATTGGTGGAATGTTACTGAGCTTTAAGGAGTTCAAGAACCTGAGCCAGGAAGATCGTGAGTTTATTCTCGCCCTTAGTCGTCAATGTGCTCAAGCCATTTCCCGTGCTCAGTTATATGAGGCAGAACGCAGTTCAAGAGCCGAAGCAGAACAGGCAAACCGAGTGAAAGATGAATTTTTAGCTGTGCTCTCTCATGAACTCCGATCGCCCCTCAACCCAATTTTGGGCTGGACAAAAATTCTACGAGCTGGACAGTTAAAGCCTGATAAGGTCGATCAAGCATTAGCAACCATTGAGCGGAACGCCAAGCTTCAGGCACAGCTTATTGAAGACTTACTCGATATCTCCCGGATGTTGCGGGGAAAACTCAGTCTCAATATTGTGCCAGTTGACTTAATTACTGTCATTCACAGTGCGATCGAAACCGTGCAACTCGCAGCTTCTGCCAAATCGATTCAGATTCAAACCAGGTTACAACAGCACTCAAAATCTGTATTGGGAGATGCCAATCGATTGCAACAAGTGCTGTGGAATCTCCTCTCCAATGCAATCAAGTTCACACCGAACGAAGGACAAGTCATCATTGGGATGGAAGAGTCGGAACAGCACATTCACATTCAGGTGATTGACACAGGCAAAGGCATCCATCCAGGGTTCCTCCCCCATGTGTTTGAATACTTCCGCCAAGCGGATAGCAGCACAACTCGTCAGTTTGGGGGATTGGGATTAGGACTGGCGATCGCACGTCAAATTGTGGAACTGCATGGCGGAACGATTCAGGCAGAAAGTTTAGGGGAAGGATTGGGAGCAACGTTCACGGTTCGCTTACCGATTACCACGGTTGTAGCAGAAAGTCCTACAGCCGGAGAATCATCAATCCAAATCGAGGATTTAACCGGGCTGCATATTCTCGTTGTGGACGATGAAGCGGATATGCGCGATTTAGCAGAATTCATCCTTGTGCAGCATGGTGCCCAGGTGACAGTTGCCAGTTCTGCAGCAGACGCATTGTTAACGCTGGCTCACTCTGTTCCTGATGTTTTACTCTCGGATATTGGGATGCCAGAAATGGATGGCTATGTACTGATACGACAGATTCGAGAACGATCTCCGGAAGCAGGGGGAAGAATGCCAGCAATTGCTCTGACTGCCTATGCTGGAGAAATTGATCAGCACCGAGCTTTAGCTGTTGGGTTTCAGCGGCATATTCCGAAACCTGTAGATCCAGAAACGTTAATCCGGGCAATTACTGAACTCTTAAAGAATCGGTTAGGCGAAGTAGAGCAGCAATGAGATCAGAAGGTTCAACACGAGCAAGGCAGTGAAGCGGTGAGGGTCTGTATGGCAATCTTCGAGGTGATAACCGCCGGATTTGAAGTCTCTAAATCCCGGTTCAATGCAAAACCTGGAGTCGTAGTGAAACAGCGCTTGGTTGACATCGGTAAGATTGGTGAGCAAGTACCACACTTCTGGAGTCGTCGATTGAGCGTAAGCGCGTTTCTGATAAATCACGAGATTATGCCTGCCAAACCCGTGTTTTTGAGTGACTTGAATGTGCAAATATTGTTCGCGGATACCAGGGGGTTGCGGCAGGTCGTTAAGGCGCGAAAAGGCTTCATCTGCATGGGGTTGAACGATTGTGCTTTTCGGCAAGCGAAACACAAACATCACATTTTTCTGAACGCACCAAGCAGCGAGTTCGATACTGTGAAACTCACGGTCGCCCAGCAAGACAAAGCGACGTGTTTTTAGTAGTCGAAACACAGGACGCAACACCTTCTGTTGATCTCTCAGTGAACTCCGCCCTTGTTTATCGAGCCACGTCCAGTACAGCGGAATTGCTCGGTTTTGGTACACGAAACTGACCATCATCAGGTTATGTCAGTTCCACTGCGTTCGGTCAAGCACGATTTGTAAGATTTGCCCACGCGGAATGTGTTGTTTGATCTACTGTTTGGCGATGAGAAACCATGACGCTTCAGGTGTCATCTGCGGCAGGCTTAAAAAGCGTTGTAGATTCCGTCGTCTACTCTCAAACAGAATCGGTTGTGGAAATAGCGTGGCTAACCGTTCGATGGTAATTCGGCGCTCTTGCTGTAATAGGTTGAATAGGATTTCCAACGTGATGAATTGAGCATCCGAGAGTTGTGATCTCAAACAAGATTGGTAGAATGAAGGCAACATTTTTGATATCAGAGGAGTGAATCAATTGGTGTCACTCCTTTTTTTCTGAGCCTATCGCTGCTATCCGGCATTGCTTCTAACTTTTAAGCTCGTTGTCACCCCCTGAACACTTTCATCCCAAGCAACATGAACTAAGTGCAAAACAATATCGAGAACAACTCTGCCACCGCTTTGAAGATTGGCGAGAAATCACTTGTCTGAAAGATGCTGCGTAAATTGAGCGAGACTAACAATTGGGGGATTATCGCGCTTAATTTTGAATATTCTCGATTAAGTTGACAGTGCCAACCAGACACAATAACTAATAATTTCAGATGGGAAACAATGACGAGAATACATGGGCGGTAACGATCCGAATCGAAGCAGTACAATTATTCTGCCTCACGGTTAAGCTGACAATACCTATTTCCACTGCAGTTCAAAGCTTGTGCAGAAGTCATCGACGGAACAGAACAGTTCTTCTAGACTAAACATGAGGGCAAACTGGGCGCGATTTTTTGTATTTTCAGCCTATTGAGTTTGCCCCTTTCTTGTCTTATTCCTTATCCCGAACTCAGGTTAATTAACACCTAGACAGGCATAGTCTAATCGCTTTCAACTAGAGTTGAAGCACAAATCAAGTTTTGTCGCTCACCACAAGCTTTACAAACGCTGATTCACAGGGAATAATAAATCAGCCTTTCGGCAAAATCATTTGACTTCAGCCCCTGCTTCCAATGTTTATGACTTCAAAGCAATCTCTCCAAGTCATTCAGCAATCCCTTGTGCTGCTGCTGACCGTTCCATTTCTGTCGCTGTCTGGCTGTAATTCTGCGTCCACAACCTCTCAATCGCCCAGTACAACTGTCAGCCCAGCTTCAACTGCTTCTAATGAAGGGAAAGCAGGTCGATTTGCACTGATTATGAATGGTCCGCCTACAGATAAATCTTGGAATCAAAAAGCTTACGAAGCTGCCCAAGCGCTTAAAGCTAAGGGGGTCGATATCGTGGTGTCGGAGTCTATCTCTCCCGCCGATGTTGAACGGGTGCTGCGGCAGTATGCAGAAGCGGGTTATAGTCCGATCGTGGCACATTCGTTTAACTATGGTGATGCTGTCTTTAAAGTGGCAAAAGAATTTCCGAACATTAATTTTGCTTGGGCAGGCGGAATTAACAAGACTGGAGTAAATGTCGCGGACTATGATCAGCCATTCTATCAGGGTGCTTATTTGGTCGGATTAATCGGCGGCAAGCTCTCGAAAACTGGAAAGCTCGGAGCCTTATATGGCTTTGATATTCCCGTCTGTCACTCGATGGGAGAGGCAATGCTGGCAGGTGCAAAGACAGTGCGCCCTGATGCGACCTTGACCGATGCGGCAGTGGGCAATTGGGATGATGTGGCGAAAGCAAAAGAAGCAGCATTGTCTCAAGCAGAAACCGGAGTTGATTTCTGGATTGGCTGTGGACAGGGACCCACTTTAGGTCAAATTGAGGCGGCAAAAACGAAGGGTGGATTTGTCACGGGCTACGTTGGAGATATGTCGTCGATCGATCCTAAAGTCGTCGCCTCAAATCTGGTTTGGAATATGGAACCGTTATTTACCAAGATGATTGAGGATACTAGATCCAAACAGTTCACGAATCAGTTTTACAAAATGGGCGTTGCAGAAGGGGTCGTTGGTGTAGAGATTCCATCGGCATTCAAAGATAAGCTCACACCGGAGCAGCTTAAATCGATCGAAGACACTCGCACCAAAATTGCTTCTGGAGAACTGAAAGTTCCGTTTGTTCCGAAGTAGACTGAGGATCAATTTAGATGAACGGTCGTCTGTTCCGAATTGATTTTTTGCGAATGAATTGTATTGGGATGTGATGATGCGTTCTAGCTCGGATTCACACGATAGTCTAGCGATCGACATGATTGGCATCACGAAACGATTTGGGGGCGTGATTGCCAACGATGCGATCGATTTTCGGGTGAGAACGGGAGAGATTCATGCATTGCTGGGTGAAAATGGGGCTGGAAAAACGACTTTAATGAATATTCTCTGTGGACTGTTCGAGCCGGATCAGGGAGAAATTCGAGTGCAGGGAAAGCCTGTAAAATTTCACTCCGCTAGAGATGCGATCGCTTGTGGAATCGGCATGGTTCACCAACATTTTAAGCTGGTTGAATCGTTTACTGTGGCGGAAAACATTGTGCTGGGGCAATCTTCTAGCGTTCTTCAAGCGTCCGCCAAGCAACTCTATCCTCGATTGCAACGACTCGCAGATGACTACGGATTGAAGGTGAATCCCCCTGCTCAGATTTGGCAGCTCTCCGTTGGAGAACAACAACGAGTTGAGATTTTGAAAGCCCTTTACCGGGAGGCGAACATTCTCATTTTCGATGAACCAACAGCGGTTTTAACTCCCCAAGAAGCCCAAGATTTGATGGTGATCCTGCGGAATCTGGCGGCTCAAGGAACTTCTATTGTTTTTATTTCGCATAAGTTGAATGAAGTGATGGCAGTGTGCGATCGCGTGACTGTTTTGCGAGACGGACAAGCGGTGGCAACGATAGCAACTCAAGACTGTACTGAACATCAACTCGCGCAGCTGATGGTCGGTCGAGACATTAATTCAACGCAAAAACTTCCGAGATCAACCAGTTCTACGCCCGGACTTGCTCTAAAGAACCTTTGGGTGATGAGCGATCGCGGTTTTCCGGCACTGAAGGGAATTGATCTTGCGATTGAGCAAGGTGAAATCGTGGGAATAGTTGGCGTTGATGGGAATGGTCAGCGCGAACTTGAAGAAGCGATCATCGGACTGCGATTGCTCAAACAAGGAGAAATTTGGATGAGCGGCAATCTTGCGCATATTCCTAGCGATCGCTATTCGATGGGATTGTTAACCGATTTCTCGATCGCAGAAAATTTAGTGCTGAAAGATGTTCAATCTCCCTCCTTTCAACAGAAAGGATTGTTGCATTGGAGACTCATTTTCAACTATGCCACTGATCTGGTTCAGCGTTTTTTGATTCGAGCGTCTTCGGTCAAGATGCAGGTTGGAAAGCTCTCAGGGGGCAATGCTCAGAAAGTTGTGTTTGCGCGTGAACTGAGTCGCGATCATCAAGTGCTACTCGCTGCCCAACCGACACGAGGACTGGATATCGGAGCGACTGAGTTTGTTCATGCACAGCTTCTTGCACGACGAGAGGCAGGCGTTGCGGTATTACTGATTTCAACCGAACTCGATGAGATTTTGAAACTCAGCGATCGCATTGCTGTTTTGTACGAAGGAGAAATCATTGCTGTAATCGATGACAAGAATGTTAACTTACACGATTTAGGTTTATTAATGGCAGGAAAGAAAGGAGGGAACTTTGCTGAATCCTAGTTCTGCGCTTTCACAGTCCTCGATTTGGCTACGACTGAAGTTTCTCGCTCCGATCCTGGGTGCAGTGCTGGCTCTGTTGCTGGGTGGAGTTCTGCTGCAATTGAGTGGAGCAAATCCAGTGCAGGCTTGTCAAGTGATGTTCATGGGTGCATTTGGAGGAACGCGGCAGTGGACTGAGACACTTTTGAAAGCTACGCCACTCCTCATCATCGGATTGGGAATGACGATCACATTTCGCTGTCGAGTTTGGAACATTGGAGCCGAAGGACAATACTATATCGGTGCTTTGTGTGGCAGTCTTGTAGCGCTGACTTTTCCCAATCTGTCTACGGGATTGTTGATTCCATTGATGTTAATCGCTGGTGTTTTTGGTGGCGCATTGTGGAGTGCGATCGCTGGATTGCTTCATCTTCTGCGCGGCATGAATTTGATCATTTGCACCTTGATGCTGAACTATATCAGCATTCTCATGGTTCAGTATGCAGCGCGAGTTCCGCTAAGACAGCCCGATGGATTTTTACCGGAATCCGCACAATTTAGCAGTAATGCTCAGATTCCCGTTTTGTTCGGAACTCGATTGCATTGGGGTATGGCGCTCGCACTGTTGCTCGTTGTTGGAGTCTATCTTTTGCTGTGGCATACATCGATCGGCTTTCATCTTCGGGTTGTTGGATCGCGGCTGAGTGTGGCTCGAAGTGTGGGTATCAATACGAGTCGGAGTATTTTGCTGGCATTAATGATGAGCGGTGGATTGGCTGGACTGGCTGGCATCATCGAAGTGAGTTATACCTATACCCGGTTGAAAGGTGAGATCTCAGATAGCTATGGATTTAGTGGCATCTTAGTTGCGCTGCTCGGTCAACTTCATCCGATCGGGGTTTTGATTGCCGCGATTTTATTTTCAGCTTTGATGGTTGGGGCACAGTCGCTAAATGTGATGTTACAGATTCCCGCTTCTGCTGCTCAAGTGATTCAAGCGCTGGTGGTGCTATTTGTACTAGCGGGTTCTGCATTGGCAAATCGTCGATCGTAAGTGAGGTAGTCATGCCCTGGGAACAAGTTCTAACCTGGAGTTTTGTGATCGCATTGCTAACGGCAGGAATTCGATTAGCCATTCCAGTGCTGCTAGCCGTATTAGGAGAGATCATCGCAGAGCGATCGGGCGTGATGAATCTAGGGTTAGAAGGCGTGATGCTGATCGGTGGACTAGCGGGTTTTGCCGTCGCTGCCAGCCTTGAACAAGCGACAGGAAATGCGAGTCTTGCGGCATGGAGTGGGCTTGCTGCCGGATTGTTCGGTGGGGCGCTGATGGGTTTGCTGATGGCAGTGTTAACCGTAAGCTTAAAGACTGACCAGGTTGTGACAGGAGTGACGCTGGTTTTATTTGGGCAAGGATTGACGGCTTATCTATTTCGATCGCGGATTGGACTCTCTGGAACACGAGTACAAGGACTAGAAACTTGGGCAATTCCAAGACTCTCGAACTTCCCGATCATCGGTGAGATTTTGTTTAATCAAACCGCGATCGTTTACCTCACAGCACTCTTAGTGTATGTTTGCTGGTTCTTCTTGTTTCGCACCAATGCAGGGCTTTCTCTGAGAGCAGTAGGCGAGAATCCAGCGGCAGCCGAAACTTCAGGATTGAATGTCGATCGCATTCGTTACCTTGCCGTGATTGCGGGTTCTGCCTTAGCAGGTTTGGGGGGTGCAGTCTTGACCGTTGTTCAACTCAGACTATTCACTGAGGGAATCATGGCGGGTCGGGGTTGGATTGCGATCGCACTTGTATTTTTCTCGCGTTGGCAACCTGTCTGGGCACTTTTCGGCGCCTTGTTGTTTGGAGTTGCTGATGCGTTGCAATATCGGATTCAAGCCTTGGGATCAAAAGATTTCCCCTATGAATTCCTGCTCATGCTTCCCTATGTGTTGACGCTTATGGCACTATTACGGGGAACAGGTCGGAGTGAAACGCCTGCATCGTTAGGCATTCCTTACGTTAAAGAAGACCGCTGATAGACGCTTCTGGAGTGAAACCGATGATTGATCCAATTCTTTGGAACGACTGGCATCCGATCGCACGATCGAGTGATCTCAAACCTGGAACTATTCTACGATCACGGTTGTTAGACACCGATATAGTACTTTGGCAAGGAGAAAATACTAATGTAATTGCATGGGAAGATCGCTGTCCTCATCGCAGTGTAAAACTTTCGGGAGGGAAAATCTTTGAAAATACCTTAGTTTGTCCTTACCACGGGTTAGCTTACAATCCAGAGGGGCAATGTGTGAAAGTCCCCGCTCATCCTAATTACACCCCACCAAAGCAAGCCTGTGTAAAATCGTTTGCTGTTGAAGAACGATATGGTGTTGTGTTTGTGTCGCTCGGCAGTCCATCGCAACCGATCCCACCTTTTCCAGAATGGGATGATCCGAGCTATCGAACCTATCTGAGTGGTGGTCATTACTGCCGCTGTAGTGGATTACGTGCGATCGAGAATTTTTTAGATGTCGCACATCTGCCTTTTGTTCATGCTGGAATTTTAGGAGAACCTGACAAAGCGGTGATCGAAGACTATGAAGTGACTTCGATCGACACAGGCATCTACATGAAAGATATCAAGATCTGGCAGCCTGACCCCGATGGAACGGGACGAGGTGGCGTTGCCGCTTATGATTATTGGACAATTCGACCTTTAACGGTGGCACTTCGCAAGCAAAGAGCAAGCGGACAAAAGATGGTGTTACTTTACTGTGTTACTCCGGTTTCTGAGGAGGAGTGTATCGGCTGGATGTGGGGAACCCTGAACTATGCCCATGACATTCCTGAAGAGGTCATGGTGGCATTTCAGGATAAAGTGATTCTTCAAGATGTGGATAATTTAGAATCTCATCATCCAAAGCGATTGCCGCTCGATCTACAAGCAGAATTTCATCTGCCTAGCGATCGTGCTTCTTTGGGTTATCGCAAGTGGTTGAAGCAATTAGGAGTCACTTACGGAGCCATTCCATAAACACTGTTGCTTATTTTTCTGAACAGTTTCGGATTTTTACTTGCTTTGGGGCAGCAATTGTTGTTCATAACAGGTTACAGGGAAACTTAAGAGAAGTAACAAAAGCTCTGCAAGTCCTATGGTTATGCTTCCTGGGTATGAAATTGTTGAGAAAATCTACGAAAGCTCCAAAACGATGGTTTACCGGGGAGTTCGATCGAATGATCAAAAACCAGTAGTGATTAAGGCACTCAAAAATCAGTACCCAACGCCAAGAGAGATTGCTGTGTTTCGGAAGCAATACAGTTTGGCGAATCATCTTGGCATTCTGGGAATTGTTCGTCCGTATAGTTTGGAGAACTATGAAAATCAATGGGCATTAGTTTTAGAAGATTTTGGGGCGATTTCTCTGAGGGATTATTGCAAAACGCATTCTCTTAGCTTGAAAGATTTTTTGTCGATCGCAATTCAAACGACTCAAATTCTCGGAGAACTGCACCGAAATCGCATTATTCACAAAGATCTCAAACCTGCAAATCTGCTGATCAATTCAACGACTGGACAGATTAAAATTACTGACTTTAGTATCGCGTCTATTCTACCGAAGGAAAATCAAGCGCTCATTAGTCCCAATGGATTAGAGGGAACCTTGCCTTATCTATCGCCAGAGCAAACCGGGCGAATGAATCGAGGCATTGACTATCGCAGCGATTTCTACTCGCTCGGAGTCACCTTCTATCAACTGCTAACCCAGCAACTTCCTTTTATTAGTAATGATCCGTTAGAGCTTGTTCATTGTCATCTCGCAAAGCAACCGATCTCGCCAGCAGAACTTAATTCAGCGATTCCAGTACCTTTATCAAATATCGTGATGAAGTTGATGGCGAAAATGGCAGAAGATCGCTATCAAAGTGCAACGGGATTACTGCATGATCTTGAGGTTTGCCAGCAACAATTCCAACTTCACAATACAATTGAGGCATTTCTTTTAGGTCAACAAGACTTCTGCGATCGCTTATCTATTCCCGAAAAATTGTATGGACGAGAAACGGAAGTCGCTCAACTGCTGACTGCTTTCGATCGAGTTGCTCAATCGGGATTCAGCGAGTTTTTGCTAGTGAGTGGCTATTCAGGAATTGGCAAATCGTCTTTGGTGCAAGAGGTTTATAAGCCAATTGTGCAGCGACGAGGATATTTTATTGCTGGAAAGTTCGATCAACTTCAGCGCAATGTTCCTTACTCCGCGATCGCGAGTGCATTTGGATCACTGGTACAGCAACTTCTGACGGAAAGCGAATTGCAACTTCGTCAATGGCAAGAAGAACTAGCGATCGCGCTCGGTTCAAACGGGCAGGTCATTGTTGATGTCATTCCGGAACTAGAACAAATTATCGGCAAACAACCTGAAATTGCCGCATTAAATCCTACTGAAGCACAAAATCGATTTAATCGCGTGTTTCAAAACTTCATTCGTGTATTTTGTCAACCAGAGCATCCTCTAGTCATTTTCCTGGATGATTTGCAGTGGGCGGATTCTGCTACTCTTCGTCTCATTAAGCTATTGCTAACAGACTCACAAACTCATCATTTGTTTCTAATCGGAGCTTTTCGAGATAACGAAGTCAATGCAACACATCCCTTAACTCTTCTTCTAGAAGGCTTGCAATTTCAAGCATTTCCAATTTACCAAGTAACGCTGAAACCGCTCTCATCGGCTCATGTCACTCAATTGATTTCGGATACTCTGAGAACGCATGAAGTAAGTCCGTTCGTTGATCTGCTCATGCGAAAAACGAACGGGAATCCCTTTTTTATCAATGAATTTCTCAAAACGCTGTATCAGGATGAGCTACTGCGGTTCGACTTTTACAAAAATTCCTGGCAATGGAACCTAAAAGAAATTGAAACGCTCAACAGTACGGATAATGTTGTTGAATTGCTGGTGGATCGTTTAAGAAAGCTACCTGATGCAACACAGCAAGTGATTCAATTTGCTGCCTGCATCGGGAATCGCTTTGACCTGAAAACGTTGTCGATCGTATTGCAACCTTCAACACTGGAGACAACCGCACAAGCTTTATCGATCGCAGTTCAACAAGGCTTAATTGTTCCACTTTCTGCGTTAGAAATTGTTCAGAGCGATACGACAGAGCCAATTTTAGTCAGCGATCGCTATAAGTTTCTCCACGACCGTGTACAACAAGCCGCTTATGCCCTGATTGACGATCGCGAAAAACAATCTGTGCATCTCCAAATTGGTAAACTCCTCTACGCTAATTACAGCGAATCGAGTGAGCAACTTTTTGAACTGGTAGGACATTTCAACCTGGGACAGGCACTCATCACCCAGGCTGATGAAAAAACTCAATTAGCGCACTTGAACATACAAGCTGCAATCAAAGCAAAACAAGCAGCAGCCTACTCATTCGCTCAAGCGTGTTTAATTCATGCTCAAAACCATCTCACAGAAACAGCTTGGTCAGAACACTATGAATTGATGTTTACCCTACATCGAGAGCAAGCAGAAATTGAATATCTATTGGGTAATTTCGAGCAGTCTGAACGCTTGATTGAAATGACCTTGAAACAAGCAAAATCTGCCCTTGAGAAAGCAGAAATTTACCAACTGCTGATTGTTCTCTACACCATGCAGGGGAAGTATCAACCCGCGATCGAGACTGGACGAGTAGCACTTTCATCCTTCGAGATTGATATTCCTGAATCAGAGTTATACAAAGCCTTTGAAGATGAGCTTGCGATCGCGAAAACACAACTCGCCCAGCAAAAGATTCCGGCATTATTAGATCAGCCAGAAATGATGATTCCAGAGAAAAGAGCCGCTGCAAGATTGCTCACAACCTTAGGAGCGCCGACTTACTTTTCAAATCATGATCTCTGGCTGATTTGTGTGATGAAGTTAGTCAATCTTTCTCTGAAACATGGGGTGATTTCAGAATCTACCTATGGCTATTCTGAGTATGGATTGATTCTAGGATCAATGCTCGGTGACTATCGAGCAGGCTATCAGTTCGGACAACTCAGCCTGAAGGTTAGCGAAAGATTTAACAATCAAGCGGAAAAGTGTAAAGGCTGCGTGGTTGTTGGTGGTTCGGTGAATCATTGGATTAGACCCCTCAAAGAAGATGCTGAAATTTTCATGGAAGGGTATCAGGCTGGCTTAGAGTCTGGCGAACTTCAATTTGCGGGCTACAATATTGCCCATCAAGTGATTAATTTATTCTACCAAGGAGCCGACCTAGATTCCCTGCAAGACAAGCTTCTCAACTATCTAGCGTTTACAGAGCAAACACAAAATCAGCTTGCAAAAGATATGCTGCTTGCCTGTCAGCTAATCTTTCACAGTTTACAAGAATGTGATGTTAGACAATGCAAGTTTGTAACGAAAGAACTGAGCGAGACTGAATATTTAGCAGCGTGTGAGGCACGATCGAGTTTTGCTGCGATCGGCTTTTTCAAGATTCTCAAAGCTCAAGTTTTGTATCTCTATGGTTGTTTTGAGGATGCTCATCACGTGATCGGGCAAGCAAGGCACCTGCTTAACTATCTCCCAGGCTGTATCTCGCTTGCTGAATTCATTTTTTACGACTCGCTGATTTTAACTTCCCTGTATCTAACTGCGAGTGAGCTGCAGAAGAGTGAATACTGGCAGCAGATCATAACGAACCAACAGCAGATGGAAATTTGGTCAGCGACCTGCCCAGAGAACTTTCGGCATCAATATCTATTAGTCGAAGCAGAGATCGCCCGATTGCAAAATGATTCAATGACCGCGATCGACCTCTACGATGAGGCGATCGCACTTGCAAAAACGAATGGATTTGTGCAAGATTCGGCATTAGCAAATGAGCTATCTGCGAAGTTTTGGATCACTACAGGAAAAGAGAAGCTTGCCCAAATTTACTGGATTGAGGCATATCATCTCTATCAATCTTGGGGAGCCTCTACTAAAGTTGCAGATTTAGAACAGCACTACCCACATCTTCTAGTTTTAGGAAACTCGAGCGTTGAGCTATCGCACATTGCAGATGAAACCTTATCGATCACTCATATTTCTTCAACTAGCACTAGCAGCACCCAGATTCTCGACCTCAGCACTATTCTGAAAGCATCTCAAGCTATTTCCCAGGAAATTCAACTCGATAGACTGCTTGAAAGCTTGCTTAAAGTAATCCTGGAGAGTGCTGGAGCAGAGCGGGGAGCGATCCTTTTGCCCGAAGAAGATCATTGGAACATCGCGGTTCAAGGAAATAGCGATCATACAGATGTTATACTTCAGCCGCTCACTGAGGAAATGCTGTCTCTATCAATTGTCCAGTATGCGGCTCGCACTCAACAGAGGCTAGTGATTCATGATGCTACCAAAGAGCCAATCTGTGCAGCTGATCCCTATGTATTGACACATCAACCGAAATCAATTCTCTGTTTTCCAATTGCTCACAAAAGCAAGCTATCAGGGATTATTTACCTAGAAAATGAGCAAACAACAGAAGCGTTTAGCCGCGATCGCTTAAAAGTTCTATCTCTGCTCTCTACACAGATTGCTATCTCTCTCGAAAATGCGACGCTCTACCAAACTTTACAAGCTTCCGAAGCTCGCGAACGCGAACGCGCCCAACAGCTAGAAAAATCTCTTCAAGATCTTCAAAACACGCAAGCGCAACTGATTCAAACTGAGAAAATTTCGAGCTTGGGCCAACTTGTCGCAGGTGTCGCCCATGAAGTCAACAATCCGGTCGGCTTTATTGCAGGAAATCTCAACCATACAAAGCAGGCAGTTGAAGATTTAATTGGGTTAGTCCAACTATACCGTGAAGCTCTTCCTCAACCTGGCAAAGAGATTGAGAACGAAATTGACGCGATCGATTTAGATTTTCTGATCGCAGATCTACCCCAAATGATTAGCTCAATGAAACTGGGAACGGATCGAATTAGAGAGATCATGCAATCGTTGAGAAACTATTCCCGTATGGATGGCAGCGAGAAACAACTTGCAGATCTGCACAAAGGGATTGATTCGACCCTCATGATTCTCTCGCATCGCTTGAAAGCAACTCCCGAACATCCAGCCATTCAAGTGATCAAAGACTATGGTGATCTACCCGAAGTGCCTTGCTTTGCAGGTCAACTGAATCAGGTTTTTATGAATTTAATTGCGAATGCGATCGATGCTCTAGAAGAAGCAAATCGAGGCAAGAGCTATTCAGAGTTAGAAGTAAACCCCAATTGCATTACTATCCAAACCAGCATTGAAAACAACGATGCAGTAATTCGGATCAAGGATAATGGTGCTGGAATGCCGTATGAAGTACAACAGCGAATCTTTGAAGCCTTTTTCACCACAAAACCGGAAGGCAAAGGGACAGGATTGGGGCTTCCCATTTGCTATCAGATCGTCCGTGAGAAGCATGGAGGACAATTGAGCGCGGTATCAGCGATCGGTGAAGGCACAGAATTTGTGATTCAAATTCCTATACATTCTTGATGCTTGCTATCGTTCAATGGTATCCATCAATTTAACTAGCACTACTCCGTTAAGTAGTTTGAGAACTATTAAATGACAAGCATGATCGGCGGAACGACAGCCAGAAATCCTGTTCTAAAAGTACGATCGAGAGACAATACTCCTAAATGACAACAGCCTGAATTCAGCGCTGTGTCTGGCTCTTAGCTTCGATCATAGTTGTCGCGACACGTATGATCGGATAGTGAGGCAGGATTCCTGGCTGTCGTCACCCGCCAATGTCGCTGGGCACTTGTCCAATTTTGGTGAATCCGAGAATTCAAACAGTCCGAAACCCAGAAAGCACGTTATGCTGGTTCGCGATCGCAACTTCGCTTCACCAAAAGTGGACAAGTACCGGTAATCGTCGCACAATACCCCCACGCGATGCGCAAGGAGTGCATGAAGAAACGCTAAGAGCGAGATGTAGAAGCGGTTTCAAGGATGAATGTATGCGATAGAAAAAGATATCAACTGCACGGCTTGGAGGCAGGCAACGATGTCTGAAAAGAATGTTAGTCTTACTGTAGCAGGTTTAGAAGTTACTACCACTGAGCAAGCCAATCCTGCCATTCCAACTTGGTTCGCAGAAGCTTTACTGCTAGGACAATACTGGCAACACTGTGGATTACTAGAGCGCTTGCAGCAACAGGTGCATGTGAATCGAGGACGGGTGGGCAAGTATGAAGTGTGCGACTTTGTGCTATTACTACTAGCTTATGCGGTGAGCGGTTTGACGAGTTTAGAAGCATTTTTTGAACAATTGAGTAGTGTTGCATCTGTGCTGATGTCAGTCTGGGGTCGGCAGCATTGTCCGGTTGCTTCTACCTTGAGTCGATTCCTCGCTGATGTCGATAATGATGCCGTTGAAGCTTTACGCGAACTTTTTGAGAGTGCCCTACTTGAACACTCACCCATCGACCCAGAATTGGGCGTGACAGACCGCAGTGGCAAGCGATGGATGGTCTTTGATGTCGATGGCACGACGAAGGCTGTTCGGCATCGAGTGTTACTGACTCAAAATACTCATCCTGTGCTGAAGCGTCGAAGTCGAAATGCCTGTAAGCCAGGATATGCCGGACGCAAACGCGGGGAAGCCGTTCGGACTCGGACCACGATTGAGCAGGCACATACTCGTGAATGGTTGGGGAACTTTGCAGAAGCTGGGAACTGTAACTCGAAAGAAGACCTCAAGCGATCTTGCACCGTAATTCAGCGCTACTGTGCGCGATCTACTTCACCCGTGACAGCGCTGTTGCGCTTAGAGGATGTTTTAAAAGACAATTGAGGCTGTAAAAAAGCTCTCCGGTCATAAGCTGTAAATACGTAAAAGCACAGCACCGAGAGAGCTACATGAGTAAATCGTATCCCAGTAACCTCACTCCTGCCCAATATGAATTGTTGAGCGACCTGCTACCTGATGCAAAACCTGGCGGACGACCGCGAGAAGTAGACTTATGGGACATTCTCAATGCAATTTTTTATGTTTTGGTCGAAGGAGTGCGGTGGCGAGCGTTACCTGGAGATTTTCCAGCATGGCAAACGGTCTACACTTACTTTCGTAATTGGCGCAAGGATGGAACCTGGTTGAGCATTCACGACCGTCTCTATCGCTGCATCCGCATCGAAGTCGGGCGCTCTCCGAGCCCATCTGAAGCAATTGTCGATAGCCAAAGCGTGAAAAGTGCGGCAGGAGTGCATGCAGCAATCGGATTTGATGCAGGTAAGGTGATCAAAGGGCGCAAGCGATTCATCACGGTCGATACGCTAGGATTGATCTTACGGGTCTTTGTCACTGCTGCCAGCACCCCAGAACGCGCCGGCGGCAAAACTGTCCTCCAGCGGGTGCGACAACGCGGCAAAGCTGTGTCTCGCCTACACACGATTTGGGTGGATGGCGGCTTCGATGGCTTTCCCTTTATGCACTGGGTGGTCACCGTCTGTCATTGGATTGTCCAGGTCGTATTACGCCCGGAACAAACCAAGGGCTTTGTTCTACTCAAAAAGCGGTGGGTGGTGGAGATGACCCAGCCAGACTGCCGCTGTAAACCTCAACTTTTTCAGCCGAATGTTTCGAGTCTGTTGATTTAGATTGTTGTTTCATTATTTGCTTCTCCAAGCTAAACCTATCGCATTGCAACTTTTGTTGCTAAGTTCGTTCATCGTCACTCTCGTTGGATTGGGCAAGCACTGATGTTTCTCCTTGCCACTGTTGGCGCATTCGGTCACTAAAAGACATTTGACGGCACTTGTTGAGCCGCTCAATTTCAGCTTCGTCTGCTCGAATAATCCAGCGATAGGGCGGTTTTTCCTGCTTGCGTCCCTCAATCCAGCCTCGCTTTACCCACTGATACAGTGTGCCATCGGGAATGCCAATCTGACGTGCCAGACCCGGAATCCACCACTCTCCATCGGCAAGCGGCTCTTTGTTATATCCTTTCGGACGGCGCTGATGCAAGCCTAACCGTCGTAATAGCTCCAATGTACTTTGATGACTAAAGCCCCCTTGTAATCGAGGCGGACGGAAGCCTGATTGGTTTAATTGCGCAGCAATTGCTGCGGCATCAAGTCCCTGTACGACAAATGCTTGAACTTGTTGACACAATTGCGGATAGTAACTTAACTGCTCAAAGCTGGCGACCGGACGAACGACAATTTGCTCACTCTGAAATCCGCCTAACCATTCAATGACCAGTTTTACCTGTTCACTTTGTCCTTGTGCTTCGACGACAATCCGATTGATCAATTGCCTCATGATTTCTTTGCGATGAGCGTTCGTTGTTGTATTTGCATTCCATAAGGTCGGAATATCTTGTGCAAGTTGTCGAATAGCACTGCGTTCGACCTCGGATAGCGTCAGCGGCTCTTGAGCTAAAAAACGCTGATAATCTTCCTGTACTTGTTCTACTGTAGCAAGCTTTGCTTCCCACTCTTTTCCAAGTTGACGGGCGACTAATCGATTTTCAGGTTCAACCTGTCGGTAATGCCGTCCAGATCGCTCAGCTTCGATATTTGCGCGCTCCAATTTTTGCTGCCACAGCTTATCAAGTTCAGTCCGCTCTTGCTCAATAGATTGAGCCGCTTGCAGGGATAGTTCTAGTGCCGCAGGCTCTAATGCTTGCAGCACTTGTTGAGTGATAGCAACATCGAGCGAACGACCTGCGATGTGCTGGCAGCCTCTGTCGGCATAGTCCTTCAACCGCCGATTGCATAGGTATTCGTGTGTTTTTCCCTGACCACTGTAATGCACAGTCATGCGGCAACCACAGTACTGACAGACCAGCAAGCCAGAGAGTAAAGCTGCTCCATGACGAGCCGCTCCAATAGTTTCAGCACGGGACTGGTTGGCTGCGAGGCGTGCTAGATTCTGTTGATACTGCTCCCAGCTAATATAGGCTGGAAATTGGTCAAACACTAGAGCGTGCCAATCTTCCGGTGCATTCACAACCCGTCCCGTTTTCGGTCGCCCAGGTTGTTGTTTGCGCGGGTCTTGCTGCCGACGACCATAGGCATACGCACCCGTATAAGCTGGATTCTTCAATAGATTTTGTAAGGTCATTCGATTCGGTTTGCGCCACTCTAAATCGCCACGATTGATCCCTTCACGAATTCGCACTGGAATTTGAATGTCCGCTCGCACCAGGTACCGTAGCACTCCGTTCAGCGTCCCAATTTCCTCAAATTTTCGGAAAATCAAATGCACCACCTGTTGAGCTTGCTCATCGGGGTCAAAAATCACTTCTCCAGACGGGCGACGGAGATACCCGATGGGTGGGTCGAATGGCAATTCTCCACGTCGAGCTTTATTGAGCTTGCCTTCGAGCAAACGGGTTTTGAGGACATGAAGTTCAGCTTCACTCATTGTACCTTTGAGTCCGAGTAACAATCGGTCATTGTACTGACTCGGATCATAAATCCCATCGAGGTCGCCAATCAATGTTCTAAACAACGCGCAGACTTCCAGCAATTGATGCCAGTCTTTCGAACAGCGTGCGAGGCGCGACATTTCAATGCCCAGAATTAGTCCCACATGGTTCAGGCTGACCTCTGCCACTAGGCGCTGAAACCCGCTGCGCCCCACGGCAGTTGTTCCTGACTTGCCTAAGTCTTCATCAATCACCAGCACACGTTCGCGCTGCCAACCTAACGCTTCTGCGCGATCTACCAAGCCATACTGAAGTCGGGTTGATTCTTGATGCTCTAGGACTTGTTGGAGGGTTGATTGTCGCACATAGACAACTGCTAATCGGTCGAGATGCAGATCGTCAATCTTCTCAGAGCGGCGGTTGTGAGCTTCACGTTTAGGATTCATGATGTTCCTCCTGCTCCAGAGCAGTGATCTGAGCGCTCATCATCTCGGTGAGAACGGCTACTAATCGTTGGCGTTGGGCAAGGGATAACTGAAACCACAGTTGATGGACTGCTGGCGGTTGAGACGGGGGGGAATGGGCTGTCCTGGCATACGACACCTGCTTGTGCGTCTAAGTCCTGAGTTGCCCGGTGCTGTGCCACGAAAATCACTAACCGCAACAACCCTTCAATACTTACAATAGGGCAAACTGAGTCCTTCGGGTTTAGGGCGGTATTCTGACTGGGTGATTGAACGAACTCTGGGCTGGCTGATGCACTGTCGTCGCTTAGTTCGAGACTATGAGTTACTTCCAGAAACTTCAGAAACTTGGATTTACTTAGCAATGATTCGGATCATGGTCAGGCGATTGGCATAAAATTTGACCGACTCCGGCTTTTCAAACACCCTCTTAGATGGGCTGTATGGTGGTGCGAACTATGTTACCCTTCTGCAACAGCGCCAGATGACGTATATTACTCGCTGTCGCGACTATCATCTGCTCAAAGAGCCAACCGTCAAAGCGATTCTCGCGACCGCTCCTCAACAACAATACCTTCACCCTGATAGTCCTGAGATCACCCGCGATTTGTTTGATATTGAATGTTTGGATGCCACTCGTCGCGGCTACCTTGAACCGATGCGATTGATCATTGTGCGATTGATTCGATTCTCCAAGCAGAAGCCCAGTGTCGGCAAGTGTGAGGGTAAGTACCTCTACGAACTATTCCTGACCTCATTACCGCCCTCTTGCTTTAGTGCAGCAGATGTCCTCAGTCTCTACAATGGGCGAGGTGGATTTGAGCAAACGCTATCTGAAGAGGATAGAGAGCAAGACTGCGACCGTTGGTGTAGCTGGCAGCCAGAAGGACAAAGCTTCTGGCAAATCTTAAGCCAATGGGTGTGGAACTGGCGCATTCAAGCAGGATGGCAGTCCCAAGCCCAACGTCAAATCCGACAAACGCTTTGGTCGCCTGCTCTAGACCAGCTAGAAACTCAAGAGTGCTCAGCCCCGACCATTGCTCCCCAATCTTTGCTATCCACACCGACCGTTAACCCACAACTTGCACCTTCTCCCAAGTATGGAGCAATGGTTGCCGTTCCAGGCTGGGGACAGAGCCGTCATAAGTACTCTGGTAAAGATTTTAAGATCATTGATGATGAAGCAATTGAGTGCCCTGCTGGACATCAGATGGATCGTCAAGAGGTGCGCTACAACCGAGTAGGCGATATGCAATTGGTCTTTGGAATTAAAGCCACCATTTGCCGAATCTGTCCAGTCATTCAGCATTGTCATGCAGATCGCTCAGCCAACACACGCGGTCGTCGGATCTGGGTGACTCGTGCAAAACTGCCAACGCCACCACTCCTTGCAGAAGTGCCAGAAATTATTGTGAAACAAAGCCTTTCCGCACTGAACGTTGGCACACAAGCGATCATCTGGACAGACATTCCAGCCACTCAGTTTCGACGAAAGCTAAAATGCAATCTAGAACGCAATCAGATTCAGATTGAAGCAGTTTCTGCTCATCGCCAAGCTATCGATTCAGCTCAACCCTTGCTCACTCGCCAGCAACGCGCCCATCGCCGCTTGAGTTGGGAGCAACGCTTGAAACGGAATCAATTGCAGGGGAAAGCGGTGAATTGGAAAGTCCAATTTTTTGGCATCTCTTCGAGTCTTGCTGAGTTTCTCAAATGCCCACATATTCCCGGTTTTCAGCGCTCATGATGCACTCCTTGCGCATCGCGTGGGAACAGCAGTTGTTCCTCGGTAGCAATAAATCTGGCAAGCTGCTGCCGAATTCGATCCGAGCTTTGTTTTCGACGGTCTAGAGCACTGAAGGGTTCCGATTCACCCCGTTGTTTGCGATCGAGCGCGGTCAAAACTTGTTGTTTCCATTGCTGAGAGTCAACAACGAGTTGATCCACCCGTTGGACTTGGCTGGGATTGTCTGAAACCAGGTTCCTCAACTGACTCAAGTTGGCATCGATCTCAGCATTTGCTTGCTCGTAAGGTTCCAGAAAATCCTGCCTTCCTGTCAGCAAATATCCTCGCAGCCCCGTTTCCATGTCCAGTAGCAACTTCTGAGTCGTGTTCGCTTGGGAAATCACTTGATTGGTATGATCGACCCAACGCAGCGCAGACAACAACCGAGTGATTTGCCAAATAGACATCCCAGAAAGCAGCAACAATAGCACGATCGGCAGAGCGATCGCACGAGTCAATCTCCGGCGGAATAGGGACTGGGAGAGTGCAAGCAGCATAGCCTTATCATAAGGGTCAATTTAACGCAGCGCAGTCACTAGAAATCGTCTTACACACTTTGAAGTAATACTTTTGGGAAAAATTAATTAGCCAACCTTTCTCCTCGTCAGTAAACTTGCAATTGTTTTGACTAACTCCTCTGGTTCTAAGGGTTTAGCAAGATGCTGTTGAAATCCGGCAGCTAGGGCTTGCTGATGATTTAGTTCTCCTGCATAGGCAGTGAGCGCGATTGCCGGACTTTGCTGTGCAGGTCGCAGTTCTCTAATTTTTTGCAGCAGCATATACCCATCCATTTCCGGCATCCCAATATCACTGACAATCACATCGGGTTTGCTGTGGAAAAAGACTGCCAGTGCCTCGATCGCACTGCTAGCAACAGTCACGTTCGCGCCTGCTTGTTCCAGAATAAAGACGGCTAACTCTCGTGCATCCGGTTCATCATCCACGACTAAAACGCAAATATCTTCTAAGGGATGAGGCAACAGGGAAAGTGAATCTAGGTCAGCCCCCGTCTTGATACTTTTGCCTGCGTCCTGGATGAGTGGCAGTCTTACGGTGAAGGTTGCGCCCTGATCTTCTCCAGGACTCTCTACGCCGAGGGTTCCGCCGTGTAGTTCGACGAGGTGACGCACGATTGCAAGTCCGAGTCCCAAGCCACCAAACTGACGGGTGATCGATGAATCTGCCTGCCGAAAATATTCAAACACATGGGGCAGAAAATTTGGGTCAATACCTCGACCAGTATCGGTCACTTGAATTTGGGCATAGCGTTGTCGGCTTTGGCTTCTAGAGGAGGGTTGAGTTGAATTTTCTACTGGGGATCTAGAAAGTTCAACGACTTCTAACCGGACAGCTACCGTTCCACCGCTCGGTGTGAATTTTACAGCATTGGTGAGTAGGTTCCAGACAATTTGCTGAAGCCGCGCCGCATCGCCTAAAACTTGCCCAAGTTCTGGAGCAAAACTCGTCTGAAGCTGAATCGATTTCGCCTCTGCCGCTAACCGCACCGTTTCCAGGGCGGCTTCAATCGTCGATCGCAGATCAACCGGAGTCATGTTCAAGCTGAGTTTGCCTTGCAGAACTCGGGAAACATCGAGTAAATCTTCAATCAGTTGGGTTTGCAGTTTGGCATTGCGTTCGATCGTTTCTAGCGCATGAGCCGTTTTTGCTGCATCTAACTTGCCGCTAAGAAGTATCTTCGTCCACCCCAGAATCGGATTGAGCGGGGTTCGCAACTCGTGGGACAACACGGCAAGAAATTCATCCTTGACTCGATTGGCGGCTTCTGCTGCACTTCTAGCCGTGCGTTCTGCTTCATAGAGATGAGCATTTTCAATCGCGATCGCAATTCGATGGCTAATGTCTTCTGCTAACGCCAGATCCGCTTCCCCATAACGGCGCTCGGATTCTGCGGTGACAAAAGCAATTGCGCCTAGAATTTGTCCTCGTGCCACCAGTGGCGAGAGAATGCAGGACTTGAGACCCAGTTCGTGCAGGAGTTGCAAATGTTGCTCATTCTGCACGGCAGCAGCGAGGGCTGCATCGGAAATTTCAGCCACGAGTTCTGACATTCCTGTTCGCAGTACCTTGGGCACTCCTTGGGCTGCATCCATTGCCACGGGAAACTGTCGATGAATTTGCCACCCCAATTCCACTTTTGCCGGATTACGATGAGCCACAGCGATGCGGTGAATAGATTGATTTTGCACGAGGTCGATTGAACACCAATCAGCAAAAAATGGCACGACAAGGTTCGCCACCTGGGTTAGTGTGTGCTCGCAATCTAAAGAAGACGCTAGAACCGTGCTGACTTCCGAGAGAAACGCGGCTCTTCGCTGGTCTGCTTCGGCTTCAAGTCGTGCCGTTTGCTCTTGAACCTGCTGCCGTAACAATTCAGCGCGTTCGGCTTCGTTCTGTTTGCGCTCGGTAATATCCTTGTTAATGCCAATAAAGAAAAGAGGATTTCCGGCTTTGTTGTACACCGTTCTAGCAGTAGTTTCGATCGCCACCTCTGAACCATCTTTGCGCTGACAGGGAACTTCCCCGAAAAATCCTCCCGTTTCGTCCATGATCCGAATCATTTCTGCCAACTTTGTCGGTTGGATATTCGGGTGATGCAGGAAATTGACGGGTCGCCCGATCGCTTCTGCTGCCGTATAGCCAAAAATTTGCTCCGCATTCCCCAACCACCGTTGAATTTTGCCTTCTAAATCAGTCATCAGAATGGCATCTGGCATTTGTTGTAATGCAACATCCGAGATCAGTAGCTCCGCTTCGGCTTGTTTACGCTCGGTGATGTCATGCATGACTACGACCGCTCCCTGGCTCTGTCCCTGGCGATCGACAATTGCCTGTCCACTGGCTAGCAGAGTTCGCGGAGTGCCCTGTTTCGGGGCAATCACCATTTCAACATTCTGTACGGTTTCTCCCTGCAACGCCCGAAACAATGGAATCTCGTCTTGTGTCAGTAACGTTTTACCATCGGGCTGATATAAGTCGTAGCATTCTGCCCACTGACCCGGTGGCAACGGTTGTTCTGGCAACCCATGAAATTCTCGTGCTGCCTGATTAAACAGGGTCAAAATTCCTTCGGCATTGCACGCAACAATCCCTGCCTGCACAGTGTCTAGTAGTATGCTGAGTACTTCTTGCTCTTTTTCCAGCAGAGTTTGGGCTTGCTGTCGTTCTGTAATTTCTAATTGAAGTTGATCATTGGCTTGAGATAGCTCGATCGTTCGCTGTGCAATCAGATTTTCTAAATCTTGCTGTGTCTGTTGCCGCGCTGCTTCGGTCTGCTGCCGCTCTAGTTCGGTCGTAATTCGGAGGACAAAGATAGCTAGGAGCGATTCCGCAAGCTGGACATCCGCTAGAGGTTTCGTATCCATCACGCCGAGTAATCCGAGCGGTGTCCCTGTGGCATCAAAAAATGGAATCGCAACATAGCTTTCTATACTCAAAGGCTCCAAAAGTGGCGCATTGGGAAACCGCTCTTGAACACGATTTGGATAGCAACACAGTTCTCGTTTTTGCAGGACTTCACGGCAGGGAGTGTCTCGCAGCCAATAGTCAAAGTTATCAATGATTTGCCCTTTAGCACAGACCGCGATCGTCTGAATGCTCTCTTGTTCCTTGCCGCTGACTAACCCAATGTAGGTATAGTCAACCCCTAGCGTTTTTGTGAGATGTTGCACCAGCGCTGTAAAAAAATCACTGCCGACTCTTGCAGACACGCCTTGGGTAACTTCCAGTAATGCAGCATCAATTTGCTTCACTTTGCGGGCGGCTAACCGAAGCTCTAGTTCATCGATCACCATTGCGGCAAGATCAATCAGTGTTGTTTCCTGTTGATCGGTGAGTGCCTCACGAGGTTGGGAATCGAGCAAGCAAAGTGTTCCCAAATTAAAGCCGTCATGGGTGATTAACGGCGCACCCGCATAGAATCGTACACCCGATTCACTTTGGACAAAGGGATTGCAGCCGAGGCGATCGTCTTGCCGCGTGTCAGGAATGACCAGAATTTTGTCAGACAACAGCGCTAAACTGCAAATCGTTGAATCGCGATCGACTTGCTGGAGGTGGAATCCATAGGCAGACTTAAACCAGCCTCGCGATTCATCAATCAACGACACCAGCGCGATCGGGACATCGAATAACCGGGCTGCTAGTGAGGTGATGCGATCGAAGGCAGTTTCGGGGGGGGTGTCCAGAATATCGTAGCGCCGCAGTGCTTCTAAACGTTCTGCTTCATTCAGGGAAACCGCAGGGGTAAGGTCAGTTGCTGTCGCGGCAGGAGTAAGAGCTTCAGTCATGGGAATCGATCCAGGGAAAAATTTGAAAGTGAGCGGAGAAGATACGTTGCCTGACTAAGTTGGCTTGAGGGGGTCAGGCTGTTTACCCACAAGGGATGCGATCGCATTCACTAATTGCTCTGGCTCGATCGGTTTGGTAAGATGCTGCTGAAATCCGGCAGCCAGGGCTTGCTGATGATCCAGTTCCCCCGCATAGGCAGTGAGCGCGATCGCTGGAAGCTGTTTCTCGCTGATCCGAAGGTGATAACGAATCTGCTGCATTAACTCATAGCCATCTATTTGAGGCATCCCAATATCACTGAGTAGGATATCTGGTTGGGACTGGGACAAGATCCTTAACGCTGCGGCTGCGGAATCTACGGCGGTCACGATCGCCTGCTCCAGCTCCAGCAAAAATGCTACATAATTCCGTGAATCGGGATCATCATCCACTACTAAAATCTGTAAACCCGTGAGCGATTGAGCAGGCGAGAGCGTTGTGGAATGATGGTCTATCCATTTTCTCATGGCTCTATCGCCCCATTCCCTCCGTAGCGGCAACTGAATCGTGAAGGTGGCTCCTTGTCCCATTCCGGCGTTCTCTGCCCAGATTGTCCCTCCATGCAGTTCAACAATCCGTTTGACGATCGCGAGTCCCAATCCCAGACCGCCAAACCGTCGGGTCGTAGCTCCATCTTCCTGACGGAAATACTCAAACACCTGCGGCAGAAAGTCTGGCGAAATCCCAATGCCAGTGTCACGGACGACAATTTGGGCATATTGGGTCATGGGTGCTGGGTCATGGGTGCTGGGTGAATCATCGCTGACCCACAACGGTTGTGTCGCGTTTTCGTTAGCGTTATCCGCATCAACCCATGACAATCCGACCTCCACGCGCCCTCCTGTGGGTGTGAATTTAATCGCATTGGAGAGCAGATTCCACATCACCTGTTGCAATCGAGCCGCATCGCCTGAAATCGGTTGCACATCTGGGTCAAGAGAGGTTTGGATCGCGATCGCTTTAGCGTCAGCCGCGAGTTGTACAGTCTCTATTGCAGCAGCAATGATAGATTGCAGTGGCACGGGAGTTACATTCAGCGACAACTTGCCTTGCATGATTCGAGAGATATCCAGCAAGTCTTCAATCAGTTGCACCTGCAATCTAGCATTGTGTTCGATCGTCGCCAGGGCTTGGCTGACTTTCTCTGGTGTAAACTGATGCGTTTGCAACATCTTTGTCCAACCCAAAATCGGATTGAGGGGAGTACGGAGTTCGTGGGAAATGGCAGCGAGGAATTCATCTTTCATGCGGCTGACGAGTTCTGCTTGTTCCCGTGCGGCTTGTTCGCGGCGCAAAAGCTGTTCTCGTTGCTGTTCAATCTGTTTACGAGCCGTAATGTCGGTCGTAGAGCCAACGACCCGAACGACTTGACCTTGGCGATCGCGGATGAGATAGCCCCGATCCCAGACATTGACCCAATGCCCCGCTCGATGACGAATCCGATACTCCACATCATAGTGATTGCTCTGCCCGGATACGATCGCTGCCCAGTGCTGCTCGACTTGGTGGTAATCCTCTGGATGCATTTTCTCTCCCCACCAAGCCGAGTTCTGGGGAACCGCTTCAGGAGGGAAACCGATCAACTCATACACGCCTTCAGAACGATAAACTTCCCCAGTTTGCACATTCCAGTCATACACCATGCCCGCAACCGCACGTGCCGCCAGTCGAAATCGCTCTTCGCTTTGACGCAGCAACTCTTCTGCCTGTACCTGCTCAGTGATATCCATCACCAAGGAGAGAACCGAGGCCACTTGCCCAGTCGCATCCGTGAGCGTGGAGTTATACCAGACGCAGTGAAGGATGGAGCCGTCTTTGGTGTAGTTGCGGTTCTGGGAAATAATTTGAGGTTCAGTGCCAGATAGGATGCGTTGGGAAACTTCCGTGATGATTGGAGTATCGTCCTCATACACCAGGTTCAGATCACTGATATAGGTGCCCAACACTTCCTCTGCCTTCCAACCAAACATTTGAGACACAGCACCCGACCACCGTCGAACAATCAGATTCGCATCCCATTCGATCACCGCCATTGGGGTGTTCTCCACATGGGAGTTCAGTCGTTTTAGCGCTTCCTGCAAAGAATTTTCTGTTTGCTTGAGTTCGCTCAAATCTAGATAGAAACAAACGATCAGTTCCTGTTCGGTATGCGGTTCATCGATCAGCGCTCCACCGATCAAAATTGGGACGCGATGTCCATCTTTGTGGAAGTATTCCTTTTCAAACGGGGTACTCACTCTGTGCTGGCGGAGTTCCTCCCCTGCTTGCAAATCAAGGTGTAAGTATTCTGGTGGTGTGAGATTAATCCAGAGAATTTGACCTGCTTCCAGTTCTTCTCGGCTGTATCCAATCAGGTTGAGCAGGGCATCGTTGGCATACAGCATTTTGCCGCTGAAGTCCCCGATCGCTACGCCAAACATGCTGATTTCTACCAATCGTCGGAATATGGCTTCGCGACGCTGGAGGTCTTCCTGAGAACACTTGAAGTCATGAATATCCACAGCAACGCCGAACCAGTGATGAATTCTGCCACTGCTGTCCTGAACTGGCGAACTGCGGCTCAGGAACCAACGGTACTCTCCATCGGCTCTGCGGAGGCGATACTCCATCTCGAACGGTTGTCCCTGCTGGGTCGATCGCTGCCAGCCCTGGTGAACGAGGTCTCGATCGTCCGGGTGAAGCGCAACTGTCCAACCCCATCCTTCTGCACTGCCAAGCGGTAGTCCGGTGTAGTCATAGAACCACTGATTGGCAGAACTGCACTCGCCCTTTGGCAAATTGATCCACAGTATCGCTGGGACTCCCTGACTGAGAAAACGATCGCACATTTCAATCTCGGACAGAGGCGCGAAGGTTGTGACCACCGCCCAAGGAACTGTGTTGTTTTGCTGAAAGAGCGGTTGGGCGTTGATCTTCAGCCAGACCAAATCCCCATTCGGTTGATAAACTCCCATGACTTCGCCAGTCACGGGTTGTCCCGTTCGGAGTGCCACCATTGGGGGATGACTATCTCCCGGAAAAGGAGAGCCATCGGTACGGATCGTCTGCCAAGGGCAATCGATGTAGTGGCAACCCTGCATTTGAGCCAGGGTAAATCCCAAAAATTTTTCCGCTACTGTGTTACAGGCTTGAATGCTTCCGTCTGCAAGTTGTAACACCATCCCAACCCGATCATCTCCAGAAACGAGCGCTGATGATCCAGTTTCAGTCGCTTGCCCATTGTGCTGCTCGGAGAAATCGTGACCGGATGTCTGGTTGTTAAGCATTTTTAGAACTCAATGTTAGGGAATGAACTAGGGAAGATTTAGCGACAAGAGCTGTTATCGCAGGCGATCGAGTAAGTTGACAATCGCTTCGATTAATTTGTCTGGCTCAATCGGTTTGGCAAGGTGTTGTTGGAATCCAGCACTCAACGCCTGTTGCTGGTCAAGTTCTCCGGCATAGGCAGTGAGTGCGATCGCTACGCAGTTGCGCTTTGCGCTAATCGCTGGAATCCTTCCTCCAGGTTGGGCGGACGGCAATTCCCGTTGTGAAGCCTCGAAAAGTCGTACTTGGCGCATCAGCATATAGCCATCGATCTCCGGCATCCCAATATCGCTGATTAACACATCTGGTTGCCATTGCGCCAGAATCGTTAGGGCTTCCGTTGCTGAGGCTACCACCTTGACCTGTGCCCCTTGTGCTTCTAGAATCGTCAGCATCAAGTCGCGCGTATCGGCTTCGTCATCGACCACCAGAATGTTCACGTTGTGTAAGTCAGCCGTTGAAGTTGTCGGGAACCGTTCTAGGTCAGTTGCTGAGGGGAAAGATTGTAATGGCAAGCGAACTGTAAATGTTGCTCCTTGTCCTTCCCCGGCACTTTCCGCGCGAACTGTTCCACCGTGCTGTTCGGTCAAATGCTGCACGAGCGCGAGTCCTAATCCCAGTCCGCCAAATTTGCGGGTCGTGGCTCCATCTTCCTGACGGAAATAGTCAAACACATAGGGTAAAAAGTCAGGGCTGATGCCTTTGCCTGTGTCCTGAACCTGGATCTGAGCAAACCTGTCACAGTGATCGAGGCGCACTTCGACCCGTCCGCCTTGTGGCGTAAACTTGACGGCATTGGTGAGCAAATTCCAAACAATTTGTTGGAGCCGAGCCGCATCTCCTGAAACCACGCTCTCATTATCGTTTAGGGCTGTATGAATCTCAATGTTTTTCGCTTCTGCGGCTAGATGAACGGTTTCGATCGCTGCCTCGATCGTCGTTGCCAAATTCACGGAACTGATGTTCAGCACCATCTTGCCCTGCAAAATCCGCGAGACATCGAGCAAATCTTCAATCAATTGGGCTTGCAGTTTGGCATTCCGTTCGATCGTGGCGAGTGCCTGAGCCGCTCTTTCTGGGCTAAATTTCTGGCTTTGCATCAGTTTCGTCCACCCTAGAATCGGATTGAGCGGCGATCGCAGTTCGTGGGACAACACCGCTAAAAATTCATCTTTGATGCGGTTCGCTCGTTCGGCTTCTTCACGAGCCGTTTGTTCTGCCACCAAACTACGAGCCAATTCAGCTTGGGCGTGTCGTTGCTGAGTCACATCGCGCAGGGTGACGATCGCGAGGATCACCTGCCCTTGCTTATCCCGAACCGGCGTGCCGCCATAGTTGCCAATAAAGGTTCTACCAATGTCGCGACGATGAGCTTGGATCTCACAATTGGAGAACGTTTCACCCTGCAAAGCTCTGGCGATGGGCCATTGCTCCATCGGGACGAAACTCCCCTGCAAATCATGCACCTCAATCGTCTCAGGGAACTTGTGTAAGTGTCGCTGGACTTGCTCAAGCGAATCGTATCCATGTATCGCCAGCGCGGCTGGATTAAATGTGAGAATGTTGCCCTGCGGGTCAGCAACCACTAAGCCCTCCGCCATGTGGTTAATCACCGCTTCGAGTTGCCCTAAGCTCGTCTCCAATCGGTGCAGCAATTGTTCACGTTCGGCTTCAGCTTGCTTACGATCGCTGATGTCCCCGATAACCCCAATCAAACGAAGGGGCGTACCGTCGGGTGCTAAATCGAATTGTCCACTAAACTCAGCCCAGCACCACTGACCCTTATCGTGCCGACGAATGCGGCAAACTCCCTGAAAGGAGCTGTTCTGCATCATGCTTTCTGCTAACTTCAGTTCAAACGCCTCTCGGTCTTCGGGATGAATGACGTTGTTGATAAACTCGACTTTGTTCAGTGTGCCTTCCGCCAAAGTGCGCCCGAAAATTTCGTACATCCGGGCGTTTTCCCAAACGGCATAATCGGTCTGGATGTTCCATTCAAATACGCCTAGGTTCGCCGCGCTTGTTGCCAAGTCGAGGCGTTGTTCTCGTTCGCGTAATGCGGCTTCTGCTTGCTGACGTTCTGCTTCGTTGCGCTTGAATTCACCTCGATCCAGCACGAAGCCAATCACGGTCTGCTCGTCCCGCGTCACCGAACCCAGAAGCATGGGCACTCGCGCACCATCTTTACGAATGTATTCTGTTTCAAACGGAGTGCAAACGTCAGTCGTGCAGCGTTCTTGCTGGGCATGGCTACATTGGTTCCACTCGGATCGCTGAGTTGCTTCCTGATACTCTGGGGGGACTATCTCGTTCCAACGAATTCGCCCAGACAGCAAATCCTCCCGTGTGTAACCTAACATTTGCAGAAAAGTATCGTTTGCTTCGGTAATCGAGCCGTTCCGATCTGCCTGAAAAATGCCGATGATATTAGCCTCTGACAGATGAGCAAATTGGGCTTCGCTGTCACGCCAAGCCTTCAGGTTTGCATCGGCGCGTTTCTTGGCACTCCGTTGAGCTTCATTCAAAGAACTGATCAAGATTGCCGCGATCGCAAACACACTCAACTGGAACACGGCTCTTAGGTTAGCTAAATCGAGCGAATAGAGTGGTTCAAGGAAAAAATAGTTTAGAGCGACCGTAGACAACAGCGTTGCGAACAAGCCCGCCCCGAATCCTCCTAACCAAGAACTGATCATCACTGCAACAAAAAACAAGGCAGCCGGAGTGCCTCGCAGCAGGGGATCGAGTAGCAGCGTGATACTCAGGGCAGCAGCGACCGCCAGCAGTGCAATACTGTAGCGCCAGACCGAAGCCTGGATTTCCAGATCGAACTGGGCTGGAAAAAACCGCTGTAGTTTTGCAGTGATTGTCCTAGTGACCATCGTTTTTCTCCTTAGCCCGACTTGATTTCATGCGGTGAGCATTTGCAGCATTTACTGACGCAATCACCCTGACTAGTTCCTCTGGCTCGACTGGTTTTGCCAGATGGTGTTGAAACCCGGCTGCAATTGCCTGTTGCTGATTCATTTCTCCCGCGTAGGCAGTCAACGCGATCGCGGGAATCTTTCCGCCTTGCTCTGCGGGTAAGGCTCTGATCTGCTGGAGCAACATATAGCCATCCATGTCTGGCATTCCAATATCGCTCAACAGAAGATCAGGTTTGGATTGAGTGAAAACTGCCAACCCTTCAAAGCCAGAAGCAACCGCTAACACTTGTGCCCCAGCCTGCTCTAAGAGAAAGGCAATCAATTCGCGAGTATCCGTCTCATCCTCGACTACTAAAACCCTAATCCCATCTAAACCCAGGGTTAGATCAGGCTCTAAACTCTCTGTGTCTGTCTCTGCTTGGGTTGGCATCAGCGGTAGCCGAACGATAAAGGTTGCTCCCCGTCCTTCTCCCTCGCTCTCTGCTCGAATCGTACCGCCGTGCAGTTCCACTAAGTGACGGACGATTGCGAGTCCTAATCCCAGTCCGCCAAACTTGCGAGTTGTTGCACCGTCCTCCTGGCGAAAGTAGTCAAACACATAGGGCAGGAAATCTGGAGCAATGCCCTTGCCCGTGTCTCGGATGATCATCTGAGCTTGATCGCCAAGGTTCTCTAGCCGGATATTGACTCGTCCCTCAGTCGGTGTGAATTTGACCGCGTTGGAGAGCAAATTCCAAACCACTTGCTGAAGGCGGGCGGAACCCCCTAGAATTTTTCTAACTGAAGTATCAAGCTCTGTCTGAATCTGAATTGACTTCGCCTCAGCCGCCAACCGCACCGTTTCCATTGCGGCTCGAATCGTCGCAGCTAAATCGACGGGAACCATGTTCAGGCTCAGTTTACCTTGCAGAATCCGCGAAACATCGAATAGATCTTCAATCAGTTCAGCCTGCAATTTCGCATTGCGTTCGATCGTGGTTAAGGCTTCCAGCGTCCTAGCCTGATTCAGTTTGCCGCTTTGCAGCAGTTTTGACCAGCCCAAAATCGGATTCAGCGGCGTTCGCAACTCGTGAGACAGCACCGCTAAAAATTCATCTTTAATGCGGTTGGCAGCTTGGGCTTCTGCTCGTGCGGCTTGTTCCCGTCGTAGCAGGTGTTCGCGCTCGGCTTCAGCCTGTTTGCGCTCGGTAATATCTAGCGCAATCCCAGTCATCCGGATCGGCTGATGATCTGCATCATAGAAGGTTTGACCGATCGCTGTGATCCAGCGTGCGCCGTGGATGGGGTGGTGAACGCGAAACTCGACATTGAGATCGCTCTGGTGTTCTAGAGACTCACGGGCAATGCGATCGGCGCGATCGCGGTCTTGTTCCACAATCGAGTCCAACCAATTGTCGTAGGAGGGCTGAGTTGTTGCCGGATCAAGTCCATAGAGTTGATAATATTCTGCTGACCAAGTGACCTGATTCGTCACAATATCCCAATTCCATACACCCGCTTTGGCTGCCTGTTGAGCAATCCGCAATCGCTCCTCGCTTTGGTGTAAGGCGGACTCGGCTCGTTTACGATCAGTGATATCCGTCGTAAACCCACACAGGACTTTACCCGGAAAGCCGACATCTTCAGCAGGGAGTTTAATCGAGAGAAAGGTGTGACGACCATCAGGGAGATCCAGCGATTCCTCTAGTTGCACCAGCTTGTTTTCCGCTAATATCCGGCGATCGTTCTCTAAAATCTCCTCCAAGTTTGGGTCGGAAAAAATTTCTCGATCGCGCTTTCCCACAATTTCTTCGACTGAGCGACCTGCCAATTGAGCAAAATGACGGTTGACCATCAAGAGTCGTCCTTCCTGGTCTTTGATATAAATAACCCCTGGTGTATTGTCCAAAACGCTCTGAAGCAACCGTTCGGTGCGATGCTGTTCCGTAATATCCTGTAAACTTGCGATCGCGCCGACTAGTGTTTGATTGTCCACAATCGGTACAGCGTTAATTAAAACAGCAACCTCAGAGCCATCTGCTCGTTGAATGAGAAGTGCCCTGTTCTTCACTGCTTTGCCTGTCCTTAACACTTCAGCGATCGGTGTGTCAGCATAACAAACCGATTGACCATTGAAGTTCAATAAGTTGAAGGCGTGATGAAATGCCTCATCGGTCGCCTTTGCGTTAGGAACTTGCCCCCATACTTCGATGGCAGCCTGATTGAAGGATTGAATTTGCCCCCTACGATCGCAGACGTAGGTTGCCACGGGAACAAGATCGAGCAGACGTAAATCATTGATGACCATCGGGTTAAGGGAAAGCAGTTTATTCATAGAGGGTGACGGACTTCACTCAACTGAAATCATAAATTCCTACTTTCCTTCCAGCCAACTGGCTTAATCTCATTGGATTGGAGGTTATCTCGGTTTCTATTAGTACTGGGGTATATGGGTGAGTTTTCCTCTAGAAAATACGGTTTCAGTAGCGCGATGCCAGGGTGATCGATTTGTCGTACCAATTCTGCGATCAGCTTCAACGCCATCGGTAAAGGTGTAGTGTGCCCATTCTCTCAGTGATTAACGGTTTTGAACGAAACCCCTAGCCGAGCTGCAAAACTCTCCTGAGATAGGTTGAGTCGCTGTCGCAGGTCACGGATTAACGTTGCAGTATTTGATAATTTCGTGATTGGCATTGTCTTTTTCTTCTCCTTTAGGAGGAAGAATAGGGCACAAGGGATACTGAGGAACCCGACTAGAGGCAGATTTTGCAATTCGGGATGATGGCAAACTATTCCTCAGGTGGGAGGTATGAAAATAGACACGAGGGACATACTCTATAGCGGGCTGCCTAAGTTGCGAATCATGCCTCATGTCTTACTGGTTGATGATGAAGCCCCTCTGCGGGATAGCCTGAGTTACGCTTTGCAGAAAGAGGGCTATGAAGTCACAACCGCAGCGGACGTTGCTGCTGCATTGAAACTATTTCACAAGCAAGTGCCGGATGTGATCTTGCTGGATCTGATGCTACCGGAGGTAGGCGGCATGGAGGTGTGTTGGCGCATCCGAGCCTTTTCCGATGTTCCCATTGTGATGCTGACCGCAAAAGATCAAGACATCGACAAAGTGTGGGGACTCGAAGCAGGAGCCGATGACTACATCACGAAGCCATTAGAGTTGTTGGGGAATAAGTTGTAGAGTTGTGAGATTCCTGCTTTTTGCCATCAGATTAAGCAGCCATCAAGTAAAAGTTCCAGAGCCCAGCAGCAGTCAGCATTAAACGGTCATCAAAATCTTTTATACGATTGCGATAGATTGCGCTCACCGCACCATAACGCTTGATGCCTGCAAACGCATTCTCACAGAGAACTCGCGATTGGCTCAAACTGCGATTTTCTTGTTTCTGCTCATCGCTTAACTCACCCCCTCTCGGTTTCTTGTGCGGAATGCGAATGTTCGTGTACTCGGACTGCAAGCCTTGAAACCCCAAATCGACTTCAATGGGAATCTCATCTGGGATATGAAACGCAATCTCTTCTTGGGCTTCAAAGCGCTTGTCGTGGAGCTTTCCTTCGCAGGCTTTGCTCAACACCAACACTCGTTTGGTTTGGTCTACTGCCGCTAGGTGCTTGCGGGTATGACGACGCTTTTTGCCGGAGTAGTTTTGCGTCTGCTGTTCTGCATCTTGAGGGCGTTGAATCGGACGCTCAGTTCCATCAATCATCACCCGTTCCACGCCTGGAAACATCTCCATGAAAGCGTCAATGCTGCGTAACTTGCGTTCGGGTAACACTAACTCATGCCCCAATGCAGTTTCGAGAATCGGTTGCAGTTCATGCATCCATTCATGCGTCTGAGAACGGTCAAGGTCAAACAAAATCCCGGCTAAATCAAAGGTCGGGTAGCATTTAAAGTAGAACAAAATGTAAAACAGCTTCGCTTCTGTGCTGTTCAACCTGGCTTTGCGCCCACCGCCCTTTGCTCGTTTTCGGACTGGCTTTGCCGCACTGCGGCTTGCCTCATACGCTTGCTCAAAACTCGGCAGCAGGGCATCAAAAGCTTTACGATTCAGTCCAGTCAAAGCTCGAAGCAAGCGATCTTGGTTTAGGGCGCGTTCAAGGTTCAACATCAGATGCAATTCACAGGATTTCTGTCTATTATCCTCTATTTCCCAACAACTCTATTTAACACGCGAGAATTGTTGGCACGCATTCGAGCGGTTTTGCGGCGACGCTCGGCGGGAGAAGGATCACCAACTGTGGATTAGGGGCAATGTGGTTGAAACGATGCGGTTCAATCAAGTGGAATTCGTTACACACAAAGCTGTTACTCACTTACTAGCTGCTCACGGTGCTGGGAACGTCGCTGATGGCAGGGTTTCTGTTGCGATCGCTCTCCGCGTACTTTATGCAGATGCGACAAACGGATTTAGAAAATTGGACGACCGCCATTAGTGAAAGTGTTGCAGATGAGTTAGAGCAAGAAAACGTTCAGCGGGTGCAGCAGTTGATGGAACGTCATGGTAAACCCGAAACAGTAACCGTGCGTGTTTTGAGTCCAAAAGGCTAGCTACTGGCATCCTCTGCCTATGAAGACTACCGCATCACAAACTGGCTAGCAGTTCCAGGTGTGCGAGAAGCTTTACAAAATCAGCAGATGGTGCAGGGAACCGCAAAAGGGGTATTAGCGAACGACGATCGCTTGTATGTTGCCCACCCGATTCGGCGAAATGGACAGCTTTTGGGCGTGTTGCGGATGTCGGTGACACTAGAGCAATTTCAGCGGCAATTTTCGTTTTTATGGTGGATGGTCATTGGAACTCTGTTGCTAACGATGCTGCTGTGTGCGGTGATCAGCGATCGTTTAGCGAGGAGTTTTTCCATCCCGATTCAAACGATGCGAAATTTTGCGATTCGCTTGGGTAGCGGTCAGTTTGGTGATAAACTCAGCATTCGTCAAAGTAATGAATTGGATGAACTCGCGATCGAACTCAATCGCATGAGTGAACGGTTAGCCTCACTCGATCAAGAGCGTCGGACGTTTCTCGCCAATGTCTCGCACGAACTGCGTACCCCAATTAAATATCCAAGTGACCGTAGAAGCCCTGCAAAATGGAGCCGTGGAAGAACCGCACTTGCGCGATCGCTTTTTTGAGTCGATTGAAGATGAAACACGACGATTAGCCCGATTGATTCATGATTTACTCGATTTGGGACGATTAGAAGCCGGAGCAACCTTGTTAGAGCAGCAGCAGATTGATCTCCAGCAACTCATCAACCGTGCCGTTCGAGCGCTCGAAACGCGAATGCAAGCTCGTCAAATGTCCCTGCATCTCAATGTTGCAAAGGTTTCACTCGTTGGCGATCCAGAACGACTTTTACAAGCCTTATTAAACATTCTGGACAACGCCATCAAGCATTCCAAAGAAAATTCTCAGGTTTCTATTACTGGCGCACGAGACGGTCAACAAGTCGTGATTACGATTCAGGATCAAGGACCGGGGATTGAGCCAACTGCATTACCTCGAATTTTTGAGCAGTTTTATACGGGTGATCCGTCCCGTAAAGGCAATAGTACGGGCTTGGGACTCGCGATCGCACAGCGCATCATTCAAGCACATGGAGGTACGATCACAGCAAGCAGTTCAATTGGACAGGGTGCGAAATTCACGATTTACTTACCACTGCACCCATTAGAGCGTTCCACCAATTGAGCAATGATCCTGACGAGTTCTTGAGCATTAATCGGCTTTGAGAGGTGCTTATGGAAGCCAGCATTGAGCGCTTGGCGTTGGTCTTCGGGTCGAGCATAGGCAGTCAAGGCAATCGCCGGAATGTCTCGCCCTCTAGAGGCGCGAATGTGCCGAATCGAGTCATAACCGTCCTCTCCAGGCATGGCTATATCGCTCACAATTACATCGGGTTGGGTATGTTCTAGAGCGGCGATCTCTGCTTCAGCAGAGCACATCGCAATAACGATCGCTCCCGCCTCTTCGAGAACTTTCTGAACCATCTCACGGTTGTCTGTATGATCTTCGACCACGAGAATTTGAAGCTGTTCGAGAGAGGGGATTTCCTCCACTGTAGTCGCTGCCATTACGTTGGGTGCCGAATCAGCGATCGTTTCTGGATGCCAATTGGAAATCGGTAGATGCACTCTAAAGGTTGTTCCTTGATTGCATCCTTGGCTGTGCGCCTCGATTTTGCCATTGTGCAGTTCAACTAACTGACGCACGATTGCGAGTCCCAATCCCAGTCCGCCGTGGGCACGAGTTGAAGAACTATCGGCTTGCCGGAAGTGATCAAAAATGTGGGGTAGAAATGTGGGGTCAATGCCAATTCCCGTATCGCGGATTTGTAGTTCAATCCGGCTATTCGCGGGCATCACTTGCAATTCGACCTGTCCGCCTTCTGGAGTGAACTTGATCGAATTCGTGAGCAAATTCCAGATAATCTGGCGCAATCGTACCGGATCTGCTTCAATTTTCCCAATCGTGGGATCAAGGTGCATCGAGAGCTGAATCGATTTAGCATCAGCTTGGGGACGGACGGACTCCACCGTTGCATCAAGGAATGAAGCGAGATCGATCGGATGAATCGAGAGTTCAACTTTGCCGCGCATCAATCTAGAGACATCAAGAATATCTTCGATCAGTTGCGCTTGTGCTTGGGCATTCCGATTGATTGTTTCTAATGCTCGTCGGGTCGTCGCTGGATCAAACTCACGATCGAGCAAGAGTTGGGACCAGCCGAGAATCGAGTTGAGCGGTGTTCGGAGTTCGTGAGAGACGATCGCGAGAAATTCATCTTTCAGACGGTTCGCATTTTCCGCTTGTTGACGAGCCGCTTGAGCGCGGATGATTTCGGCAGTTTTAGCAATTAATTGGGCCGCTTGCTGTTGGACTTCGAGATTTTTCTTAAATAGACCTCTTGCGAAATAAAAGCGAAGTTTGAACAGCATCATAACGAACTGGATAACTTGAGATTTAAGCAGCAATCAAGTAAAAGTTCCACAAACCTGCTGCAGTCAACATTAAACGATCATCAAAATCGGCGACATGATTGCGGTAAACGTGGCTCACGGCATTGTATCGCTTTATTCCCGCAAAAGCGTGTTCACATTTGACCCGATGCTGACTCAACTCCCGATTTTCCTGTTTCTGTTGCTCAGTCAACGCCTGCTTTTTTGGCTTCTTGTGCCCGATTTTGATGTTGTCGTACTGATTCTGTAGCCCTTGAAACCCCAAATCTACAGCAATGGCGACTTCAGTGGGAATGGTATGAAGTGTCAACTACCGGAACTTGTCCACTTTTGGTGAATTAGATGTCAAAATGGAATAACAGCTTTTTCCATTTGAATGTGGAACTTTTCAACGAACTATTACCTAATCGAGAACATCTACAGCTTCAAGACTACCAGGTAGATCGCGACCAGCACGTTATTACTATTTTCGTCTGTTCAACACAATCTAGTAATCCTTGCCCATTATGTGAACAGCGAGCCAAGCAAGTTCATAGTCGCTATCGTCTGATACTGGCTGATCTGGCATGGGCAGACTACCGCATTGGAATTGAAATAACGGTGCGAAAGTTCTTTTGTCGGAATTCTCGCTGTGAGCGGCGAATTTTTACTGAGCGTCTTCCCGATGTTATGGAACCCTGGGCAAGACGAACGCAGCGTTTAGCCGAACAGTTGTATGAGATTGCGCTGGGTTTAGGGGGTGCAGCAGGCACAAAATTGAGTAAAAAGATACATTGTGGTGTGAGCCGAAATACCTTGCTGAGATTGCTGTTCAGACAGCCACTGCCTGCTTACGAAGTTCCCAAAACTTTAGGAGTGGATGATTTTGCTTTTTGTAAGCGCTTGAGTTACGGAACGATTTTAGTGGATTTAGACGCACGAAAGCCGATTGCGCTACTCAAAGGGCGGGATGCGAGCCTGCTTGCAGAATGGCTGAGACAGCAGCCTGGAGTTGAAGTCCTGTCCCGTGACCGTTCCCCGGTGTACAAAAGCGGGATGAGTCAAGGTGCGCCGAATGCGATTCAAGTTGCAGACCGCTTTCACCTGATTCATAACTTGGCTGAGGTGTTAGAGCAAGTTTTTAGGAGCCACAACAGTGACTTGCGACACATTACGTCTACTCATACAGATCATCAGAATCGTGAGGAGCTTGAACGAAGCCGCAATCAAGGAGAATCTATTGAGACTGTCGAACCCTTATCCACAGTGTTAGAGCGCTTGGATGTACCCATGAAGACATACTATCAACGTCGTCGCGCGTTACATCATGTGGTTTGGCAACTTTTTGAGCAAGGATGGTCAACTGAAGCGATTGCTCGATATACCGAGATGAGTATCCGAACCGTACAGCGCGACCTCAATAAACCGAAACACGTTGAGCATCAACATCGGGCTGATTATGGTCAGAACCTAGCAAGTCCTTATCGAGACTATATACTGCAACGCTGTACACTGGGTCATCGATGCGTCGGGCTGTTGGCGGAACTTCAAGCTCAAGGGTACAAAGGCAGTGACCGAACGTTGAGACGGTACTTGAAGTGGTGAGCAAGCGAAGAACCCAGCAAAGAACCAACAGCACTATCTTTACCTGCTTTGCCATTAATGAATGCCCCACCGCCAACTGCTTGGCATCCACCTTTGAGTGCGAATCGAGCCACTTGGTTAGTTTTACGCAAAACTGAGCCTGAAACTCTAAGAGAACAGCAATTGCTTAATGCTTTACAGTCCTCTCCTCAGTTTGCTCTGGCCATTGATTTAGCTCAATCGTTTGCTCGATTAGTTCGAGAGCAACAACCGGAGCACTTTGAGGCATGGCTAGACCAGGCATTACACAGCCAAATTGCTGCTTTTGTCAACTTTGCCAATGGTTTGAAGGAGGACTTTGCTGCAGTTCAAGCCGCAATGAAGCTTAGTGCGAGCAATGGTCAAGTAGAAGGGCAAATCAATCGATTAAAGCTTCTGAAGCGGCAAATGTATGGTCGGGCTGGAATCGAACTGCTGAGGCGACGGTTTCTAGTAGCAAATTGAGCTATCTGGTAAGCCTATCATAAGAAGTTGCTACGAACCTTCAAGTAGACTGACAACAATCAGATACCACAGTGTCTAGCTCGCTTGCTTCACCAAAAGTGGACAAGTTCCGGTAGTTGACGCGGCATAGACGACGGCGCTCGGTGCTTCCATTCCTAAATTAATGCCGATGATGCAACGAGAATGTGTATCCACGATCGTCGTTAGCCACGGTCGTCCTAACACTTCTCCCATTTGATCCACAACCAATAAGTCCGCCCGCGTGTGGTCACATTGCCACACTTGATTACTTTCTTTGACTTCGACTTCTAAGCCTTCACGGGTTTTCAGGAGCAAGGTTTCGCCACTCCAGCCAATGGAACGGGAGCGCGATCGCTCCTCTTGTCGATCCATCTCACTTTGCAGAACGCGATACACACTCGCTCGGCTCGATGGATGACTATCGCCGATTTCTAATGCCCGTGCTGCCACTCGAACGGCAACTTGGGCACGGCTCATTCTGCGTCCACCCCGATTCCCAGCCCGATACGTTTCCAGAATGTAATCGCTCCAATCTTCGTCGAGTCGCCGCTCTCCCCGATCCGATCGCTCTTGTCGCACAACGCCATCGACTCCTTTGGTTTGCCACGCTTTCATCAAAAGCTGCACGTTTCGCACCGTCATGTTCAATTGCTGGGCAACCTCTTGCTGAAGCGCGAGATAAGTTGGGCGATCCGGCGCATTTGCCAACCGCTGCATCGATTTGACGCGCTCTTGCTCAGCGAGCGTCAACGACCGCGATCGCACTTTGACGCCTGCGTTGTCTGGAACGGGTACTGGCTCAGCTTCCTCGATCGTCATGCCCTACTGCTGCGAAATTTAATCTGAGATTCGACGCTGTTACTCTACACCCGTCCAAGGTCGCTTCTGTTCTCGCTTTACACAATTTCTCCGTTCGTAACTTTCCGCAAAAAACGTAATTTAATCTGAGACAACCTATTCCAGAAATTTACGAAAAATAATTAATTCGGTAAACCCCCAGCTCGGCTGGGGGACTCCCAGAGTTTGACAGTTCCAGGAATCTAAGAAAGAGTCTCAAAGACACGAACACAGTGATTCGTGCAAGGAGACTCAAAATGAAAGATATCGGAAGTTTAAGTCATACGAAGTGGGAGTGCAAATATCATGTGGTATTCATCCCCAAGTATCGAAAAAAAGCGTTGTACTACGAGCTACGGCAGCATTTAGGCGAATTGTTCCGAGAGTTGGCAGCGCAGAAGGAATGTCGGATTGAGGAAGGACATTTGATGAGCGATCATGTGCATATGCTGATCTCAATTCCACCGAAGTACTCGGTGTCGCAAGTGATGGGATACATCAAAGGCAAAAGTGCGATTAGCATTGCGAGAACGTATCAGGGGCGGCGGAAGAACTTTACGGGACAACACTTTTGGGCAAGAGGATACTATGTCTCGACGGTGGGACGTGATGAGGCATTAGTGCGCCAGTACATCCGGGATCAAGAAAAAGAAGATCAGCGGGTGGATCAATTGAATTTCTTCAACGAGTAGCCCGAATGCCTCCTTCAGGAGGTGCTGAACTGCCGCTTTGAGCGGCGCACATACGTTAAAGCCTTCGGCTCTGCCGGAGGTTTATTACTCCGGTTTCATCTATCACCACGCTTACCGAGCATTCTTCACCAGATGCAGGTATCTCACAGCAACTATTCACACCGTCTCATCTTCGTGATTTTCAAAAGCCGCTTACGGATGCTCGTTTGCTGCAATCTGAATCGTTGCAGGATCAGATTGAGCGCAACCCTGTAGAAATCGCACAACAGGATTCAGACCCATCATCAGAAGAGGAAGAAATTATTGGAGTCGAAAAGCTTCAGAAGCCAACCTCAACTCCGGTCTATACGATAGACTCCGATGAAATTCGGCGTGAGAGTGCGGATAGTTTAGCCGAAATTTTGCGGAGGTTGCCCGGATTTGCGGTCAATGATGCTGGCTTTGGAGCCGATATTCACACTGGAACTTTCTATCGAGGAGCTTCAATCAATCAGTCTGTATTCCTGCTTAACGGAAGACCGATCGGCACCAATGTGAATATTTATCATGGTGGCACTGATTTAAGCTCAATTCCCACAGGTGCGATCGAGCGAGTCGAACTCACGAGCGGAACGGCTGCCACGCTTTATGGATCTGAAGCGATCGGGGGTGTTGTTAATGTCGTTACCAAGAAAGGAACTGGCATTCCTCAGTTTAATGGCTTTGCTCAGTTGGGATCATTTAGCACCTCGAACTATCGCGGCAGCTACTCAGGGGCACTCGGAGCGGTCAACTATCTATTTAGCTATCAACGATTTAAGGCAGATAACGATTACTTTGTTCCGGTTGGAGCCGCAAATCGAGGTCCGGATGGACGATTGTTTAATGGCGATTCGACTCAAGATAATTACTACGGTAACTTGAGCTTTGACCTCAACGATCGCAACTCACTCAGTTTAGATGTTTCGACTGTGACCAGTCGGCGCGGCTTGTTGTATTTTGGATTTCCCTTACAGCGCGATCGTTTAGATCACGATACCGTGAATGTCGGTTTGACTTGGAAAGCAGCGCTAGGTCGTGGAGACGATTCAACGCTCAATACAACTCTGTCGTTTAATCAAGACTATTTCAGCACTTACGGACCCACACAAACCACATTCTTTCGCCGAGGGATCGTAAATTCTCGCGGCTTCAATGCCAGAGTCGAACATAACTGGCAAACCAGCAAAACGAACAATTTGCGATGGGGCGTTGACTTACAAAATTCGCTGCTCAATGGAGAAGCCTTTAGTACGCTGCCGCAACTAGCCCAATTTAACGGTGGGTTCGACCGCGATCGCTTTCAAACTGCTTTGTTTGCCTTAAATACCTGGCAAATTACCAACAGTTTCCAAGCCGAATTTGGTTTGCGTCAAAACTTTACGAGTGAATTTGGCAGTTATCTCAATCCTAGTGTTGGAACACGATGGGCAGTCTCTCCTAATCTTGCACTGCGAGGTAGTTGGGTATCTGTGCATCGTAATCCGGGCTTGGATCAACTGTATGCGTTTGATACGGTTCACAATTGGTTGCCCAATCCTAATCTCAAGCCTGAAACCGGATCGTCTTGGACGGCTGGGATCGATGTACAACTGTCTCAGAGCTTTGCAGCACAGTTCACTTACTTTGGTAGTCGGTTGAACGATCGCATTGCCGTTCAGTCGGGGCAATGGGCGAATATTGGATTAGTCAACACGAACGGCATTGAGGCAGCATTGCGCTGGCAGATTGCGCCACAGTGGTCTACGTTTGTCAACTACACTTACACCGATGCCAGGATTGGTAGTGGTGTAGAACAAGGATTGCAGTTGAGTACGATTCCGTTTTCAGTGGCACGCTTTGGAATTGGTTATGCCTCAAACGGCTGGGAAGTCAATTTATTTGCCAATTACTTCAGTGGCGCACGACGCGCTTTATTTACGCTTGCGAGCGATAGTTCTCGTGATTTTTCACCCGCCTGGATCAGTTTTGATCTAGGCTTGCGGATTCCCATTGCTCGTGGATTAGGTCTCAGCGTGTTTCTCGAAAATCTTGCCGATCATAGCTATGAAAAAGTGAACCGGATCTATCAACCTGGTTTGACTTATCGAATTGGTCTAGTTTCAGATTTTTAGGCATTGCCGGATTAATTGGTTTTCGTAAGTGTCAAGCTTCTGAATTCCTTTAGCTCTCAACCTTGGAGCTGATTTATAAGGAGAATCTAAACGTAGACGACGATTCGCTTAATGCTGAAACGAATGACCGCTTAACTTCTTGCTTATGAATTCTGTAAGGCTTTTACTTGCTTATAGTGATCGGGAATGTACGATTGCCCAACGTCCATTTCCTCGCTATCGTGGATTGTATGTATCAAGGTTTAGATACTACCCGCTCGATGCGTTTGATGATGGTTTTCCTGATTCAGTTTGCTTCACCAACAGTGGGACTGAGAAAGTTACAGGATTGTCAGTCAAAGTGGGAGAGCGCGTTTTTCAGCTTGAGAACAAAAACGGACTGTTTCTGATCTCTTCGGAAATAGCAAACATCTAAGTACAGGACAAAAATTGTAGAGTATCGTAACTACTCAGGTTAAAAGATCGTAAGGAATTGTAGGCAAGTACGCAAATAACAGTAAGGTTCAAACTATTCAAAGTTGTCGTGAGGGCATCCTCTTGAGCGACCCTACTCCTAAAAATCTGGCAATGAGTCGCGACGAAATCCGAGCGATCTATGCCCAAGGCGAAGATGCAGTCATTGCTCTGGTTGAGGGGTTATTGCAACGGATTGCTGGACTAGAAGAACGGATAGAAGCTTTGGAGAATCAACATGCGAAAAATAGCCGCAATAGTAGTAAACCACCATCGGGAGATGGGTTTGCGCCGAAACCGAGAAGCCAACGGCGCAAAAGTGAGCGCTCCAGTGGGGGGCAAAGCGGGCATCCAGGAGCGACCTTAGAGTGGTCAGAAGAGGTAGATGCTGTGATGGTTCACCCGGTTGAGACTTGTGAAGTTTGTGGCATCTCGTTGAGAGCAGTCGAAGTGGAATCGTGGGAGAGTCGCCAAGTGCAAGACCTAGCCCCGATTCAACTCAGCGTTACTGAGCATCGAGCCGAAGTCAAGTGCTGTCCAGGATGTCAAACCCTGAATCGAGGAGCGTTTCCGGTCGGGGTGAATAGCGTGGTGCAGTATGGCGCCAGCTTAAAAAGCCTGATGGTGTATTTTCTGGACTATCAGTTGTTGGCATCTGCACGGGTGGCAGAACTGTTTGCGGATATCTTCGGCTGTTTGCTGTCCGAAGCGACGCTGTATACCAGTCGAGAACGATGTTTTGAGACATTAGAGCCGATTGAGGATTGGATTTTCGAGCAAGTAGCGCTTGCGGAGGTGATCCATTGTGACGAAACTGGAATGCGAGTCAAGGGTGGATTGTGGTGGCTGCATGTTGCCAGTACCGATGGCTTTACCTTCTACTTTGTTCATACCAAGCGGGGTAGAGCAGCCCTTGAGGCGATGGCACTGCTGCCTAACTTTGAGGGCGTGAGTGTGCATGATGGCTGGAAAAGCTATGCCCAGTATGAGTGTGACCATGCCTTATGCAATGCCCATCATTTGCGAGAACTCGAATTTATCCGAGAACGCTATGCTCAGACTTGGGCAGAAGAGATGAGCATTTTGCTGTGCGATCTCAAACAGCAAGTCGATGACGCAAAAATGCAGGGACACTCCACGCTCAGTCGCGACCTCGTGCAGTGGTTTGAAGAACGCTATGTGCTGCTGATTGAGGCGGGATTGTCTCTCAATCGCATCAATGACCCGCCGCTTGATGACGCAAAATCGCGAGGACGACCCAAAAATCGCCCGCAAAGAACTTACTCGACCGCTTACAGCAGCACCAAGCGCAGGTGTTAGCATTTATGCTGGACTTCCGCGTTCCCTTTGATAACAATCAAGCCGAGCGCGACCTTCGCATGATGAAATTGAAGCAAAAGATATCGGGTGGATTTCGCTCCGTTGAGGGCGCACAGATGTTTGGGCGGATTCGCGGCTATATCTCCACGCTCAAAAAGCAAGGGTTGAATGTCCTCGAAGCACTCAAGCAAGTTTTCTTGGGCAACCCGACAATGCCAACGGTGCTTCAGCCTGAGTAGTTACAGAGTATCTATGAACTCACTCATCTTTTGATCAAGGTTGAACAGGATGCTACGGAGATGATCGAAGCCATAACGAAAGATGCTTTTGGCTCTGCGACCATGCTTTTTCAGCTTCAGGGGATTGAGTTGATGCAACCACTCTCAGACTAAGATCGCCCAGCACAAGGCTAATGAAAGGAGTGCTAATAGCTTGCTCAAGCGCTTGGGGTCAGTCAGGTGAGTCGATTCCAAGCAGAAGCCACGGGTCTTGAAAATGCCGAATAGGGTTTCAATGCCCCATCGCTTGGCGTAATCGGCAATCGCAGACTTCGGAGCGCTTTGGGTAGCGACCACGAGCAATTCGCCATTCTCTAATCGGGTTGCCGCAATGTAAACCCAATGCCCCCATAAACGGCGTTTGTGCCGCAGCACCTTCGTTTGACCGACTTGCAAATCCGCAAAGAGAACCCGAACTTTGCGACTGGTCTGCCCATCGCTCAGTTTGTGATTCTCACGAATCCGAATCCGAAAGGGCGTGAGCGGGTCTTGCAACAGGTAGCCAAACCAAGCTTTGCCGACAAACTCCCGGTCTGCAGTAAGACAAGCAATGTCGCGATCTCCAAAGCGTTCAAGAAACTGGTTGAATAACTCCATCTGTTCTGTACTGTTAGAATTGCCTCGCTTATCGAGTAGACACCACACCAGTGGAAACGCAACCCCATCCTGCACCACACCCAACATCAGGATATTGAACACACAATCGCCAAACTGCCAATCGGTACGGTCAATCGATAGCACCCAAGGTTCAGGAATTGCCATCAGGGTGACAATGGCTTGGGCAATCTCTGCATAATCCATCTCGTAATCTCGGAAAAATCGTTGCAGTCGCTTGTAATGTGAATCGGTTTGAGCTTTGCCATTGAACGCCGTTGCCAGTTCGCTAAAGTTAACGGTCTTCACCCGAAACAAGGCAATCAAGAAAGCAGCAACAAAGCTCAATCTTGCGCCATGCCAAGCGAGATGCGGTCGCAATTTCTCTTGAAGTCGAGTAACCTGATTCATAGGGGTTTTGTGGTTTAAGAATGTGGTAATTCTCATGAAACCCCTTCCTATGAATTATTTGCAAGCTTTTGTCCTGTACTTAGAGCAAACATACTAAAGACTGCACCAGAACAATCTATGCAATTGAGAGCAACAGCGGATAACGGCGAAGTCGTTGACAGCGCGATCGGACAGGGAACTGTGAGAGCTTGGAGAAGCATTTACTAAGCAATTTCATCTCACTCTGTCTGGTTAGAGAATGTGCTGAGTGATTCAACACGCCAAAGTATTTAATACGATTAGCGTAACCGTCTCTTGAATTTTGCGATGCTCTTTCATCTCGCTTTTTCAGCGATTTTCAGTTCAATCATCGCTCTAATCATGACTCGATGCGCTACAGTTTTTGCTTAAATTGCAGTCGATCGAGTCTCAGTTGGTGTTGGATGTTGAACAATGATCGAAAGCCTAGCAATACAATTCCAATCGTCGCTAGTCCAGTTGCGGCTGCGATCGCAAAAATCAGCACGATTTGATAACGGACTGCATCGGTTGGACTTGCTCCCGCGATGATTTGTCCCGTCATCATTCCAGGTAAGCTTACCGTTCCCATGACCATCATTTGATTGATGGTTGGAATCATCCCCGTTCTCACCGCTTCTCGAATGGTTCCCTGTGCAGCTTCCCAACGGGTCGCGCCCAGTGCTAGCAATGATTCGATTTGGTCTCGTCGCACCGTCAAATCTTCGGTAAAGCGATCGAGTGCTAGGGATGTTCCTGTCAGTGCATTGCCTAAAATCATCCCAAGCATCGGAATAATATATTGCGGATTGTACCAAGGCTCAACGCGAATGATTCCGCTCACGATTGCTCCCAGCATCAGTGCAGAAGAAGTAAATATCGAAACAAAGCTATTCCAATACATTCCTTGGTAGCGGCGTTTTGTTCGATCAATCGCGGATTGCCCTGCTAGAAGCGTCATAATCAGCGCTACAGATAGCACCGACCAAGATGATTGTAGTGCAAAAATCCATTTCAATACATAGCCAATCAGTAAAAGTTGAACTGTCATCCGAATGGAGCCAATCCATAATTGTTTCTCCAAGCCAAGTTGTAAGACGATCGAGAGGATGAGGTTGATCAAAATCAGCATTGCTGCTAGTGCAAGCTGTCCATCACTAATCAGAACATAATTTGTCATGGCCGTTTGAGGGTTAATCGTTGATCGGTCATTCGCTCTAATTGTTCTGGATTATGGCTTGTCCAGAAATACGATCGCACTGGGTTTTCCTGCTGCCAGAGGCGCACAAGAGCTTCAAATCGCTGCTCGGTCTGAGCATCGAGTGAGGCAGTTGGCTCATCGAAGAGCATAACAGTTGGAGAACAAAGTAAGGCTCGTAGGAATGCAGCGATTTGACCTTCTCCACCAGAAAGAGCATGAGTTGGATGATCGAGAAAGTCAGGCGATCGTCCCAGAATTGATAGATATTCTAGAATTCGTGGTCTTTGATCGCGGTAACGATCCGGCGAACGACGAACCGCCATTCTGTAGATCGCTTGTAAGTTCTGTTCAACAGTTCCTTCGAGCAGTGCAGGGCGTTGATGTAAGTATAGAACTTGAGTTCGGTAATGGGGAATGAACCAATCAGAAAGGGATTTTCCTTGAAGAGCGATCGTTCCAGATTGAACCGGGTCGAGTGCTGCGATCGCTCTCAATAGTAATGTTTTTCCGGCTCCGGCTTCTCCAGCGATCGCACATCGTTCTCCCGGATACAACTCAAAGTTGATCTGCTTCCAAACCCAACGTCCTTGAATCTGCCGCCCTAGATCCTGAATAACTAACATACTGATTCCTATCGGTACAGCAGAATCAATATACAAAATCTTAAACTCAAAGTGAAAGTTATGTGAGTTTCTTTACTCCAGCGAATATTCTATTCTTCACTAATCTAAATAATAACTCTAACCCAGGGCGAGGTCGTCAATTTGAGGCGGGGTGAAAGCAGATTTCAACGATCGCCCCATGCCTGATCGATTCAAACTGCCCTTGTTTTTTGCACACAAACAGGTACAATTAGGACTAATTTGCGTTAAGAGTCTTCTCTTACGATGACTTCTACTCTCCCTAAAGTTTATAAACCTCTCATTCCTCCTGTGTTGGGACTCGGTTTAGGCACGCTCATCTTGCTAATTATTCTGATTCACAGTGTCACCCTTGGTGCAAGAGATATTCCATTGCCAACAATTCTGGCATCGTTTACGACCTTTGATAACTCGTTTGATCATTTAGTAATTCAAACCGTTAGATTGCCACGATCACTGATTGCTCTCTCCGTCGGTGCTGCTCTTGCAGTCTCAGGTGCATTAATGCAAGGTTTAACTCGCAATCCACTCGCTGAAACCGGAATTTTAGGAATTGAAGCAGGCGGTGCTTTAGCGGTTGTCATTAGCTTATTTCTGTTTGGCAGTTCCTCGTTAACGATTTATGCAGGAGTAGCATTTTTAGGAGCCGCGATCGCAGCAATCCTTGTTTACTTTCTCGGCACATTGGGTCGAGGTGGCGCAACTCCGTTAAATCTGACAGTTGCAGGAGCCGCAATGTCTGCCTTGATTGCTTCAATCACGACTGCCATTCTGATTGTGAGCCAGCGCACGCTTGAGGAAATTCGCTTTTGGTTAGCAGGATCATTAGCAGGACGGGATTTTGATTTATTCTTGCAAGTTCTACCATTTTTGAGTGCTGGATTGGTGCTTGCATTCCTGCTCAGTCGGCAAATCACAACAATTAGTTTAGGTGAGGAAGTTGCAACAAGTTTGGGACAGCAAACCCTTTGGGTGAAGTTTCTAACTGCTACGAGCGTTGTTCTATTAGCAGGAAGTTCGGTCGCGATCGCAGGACCGATCGGCTTTATCGGCTTAGTTGTCCCCCATATGGTCAAATTTTTCATCAAGACCGACTATCGCTGGATTTTGCCCTATTCAGCCATCCTTGGAGCAATTCTATTGTTAGTGTCTGATATTGCGGCACGAGTGTTATTAAAGCCTCAAGAACTTCCCGTTGGCGTAATGACTGCGATCGTCGGTGCGCCGTTCTTTGTCTATCTTGCAAAATCGAAGGTGAAAAAATGAGCGATTGGCGTTCTCCTGTACTTTCTTTTCGGCTTGATCGACGAGTGCCTGCGATCGCGCTTTTGCTACTCGGAATTGGGTTTGCAGCAATTGTTTTCAATGTTGGACGAGGAGAATATCCGATTGCAGTATTCGACATCATCAGAACCTTGTTTGGGATTGATACAGGCAACCCGGATCATGCGTTCGTGATCCAAACGTTACGCTTACCTCGGACTTTAGTTGCATTCATGGTTGGGGCTGCACTCTCCCTATCAGGTACTATCTTTCAAGGCTTAACTCGCAATCCACTCGCTGACCCTAGCATCATTGGGATCAACACTGGAGCAAGTCTTGCAGCGGTCTCGGTGATTGTTTTGTTCCCAAACGCGCCTGTTTATGTAGTTCCGTTTTCTGCGTTTGCAGGTGCAGCATTAATGGCGATGTTAATCTATGGATTAGCCTGGCATGGGGGAAGCTCACCGACTCTGTTGATTTTGATGGGGATTGGACTCTCTGCGATCGCGAGTGCGTTTACCAGTCTGCTGATTACCTTTGGCTCAATTTACGATGTCAGTCAAGCTTTGGTCTGGTTAGCAGGGAGTGTTTACGGTCGCACTTGGGAACAATTTTTTTCATTTCTTCCCTGGTTGATTGTCCTTGTACCTGCTGCATTCGGGTTAGCAAGACATCTCAATGTGCTGAATTTAGGGGAAGACATCGCGAAGGGATTAGGCAGTCGAGTCGAATGGCAGCGAGGATTGCTAGCCATGGTTGCAGTCGGATTAGCGGGGGCATCCGTTGCAACTGCGGGAACGATCGGTTTTGTTGGGCTGATTGCGCCCCATCTGGGACGGCAGATTGTGGGCAATCGTCATGAAGAATTACTGCCGATCTCTGCACTTATTGGAGGGGTGTTAGTGGTAATGGCTGATTTTGTGGGGAGAACAGTTTTTGCACCAATCGAGCTTCCTTGTGGAGTCGTGACAGCGGGGATCGGAGCGCCGTTCTTTCTCTACTTACTGGTTCATCAACGGCAAACTGCGTAGCGATACTTTACTCTGCATCATCTTGATTGGAATTTGCAGCTAAAGTGTATATCTATCGAGTGCTAGACAATCGAATTGTGCGATCGCAGAAGTTACTCCTCATCTTCTTTCTCCGGTGAGAAGGTGAGAATGGAAGGAATACAGGCGAGTATTGTAGATTCTAGCTGCTGCGGTTGATTTTTCCAGCTAAAGCCACCTTTGGGATGATTGCTACACATCTGGATGAGTTGAAGTAACGCATGATCTGTGTCAGGCGACAAATCACCGAGTAAATAAATGCGTTTTTCTGGATTCGCTAAGGCAACACAACCATATATTTTCTCAAGAAGAGATCTCAAATAGGCTCTACAGAATTGGCAATTACTACTGCTCATCAAACCATCTTATTCCTTTAGAGCTGATATTCAAACTCATCTTGATTCAAAACAAAAGATGCCGAACAGTCTAAAGGCGAAGCTTTTCGACTATGCGGCATCCTTGTGATTAAACGCATCTATGATCAAGCGTACCTAAGCTCCCATAAAATTAGTGATAAAGGTTCTCATTAAGCGTATAGTAATAGACGAGTGTTGAGCAAGCCTGTGAAGTGGCTGATCAACGAGGCTCATCTCTTGGCTTAAGAGAATGTTGCCAGATTAGAAAGATAGGGAGGTCAAGAGAAATATGACATAACACCTGACAATGTGTTTGCAGGAAGCAAACTAGTTCAATACTACTAAAGTATCTGGAGCTAGAAAATGCGCCAAGTGGTAAGCCCGTTCCTCCGTTTTGAGCAAGATTGTCTCAAGTAGATGGCGGGTGGCACGATCGCCTAGGCTCTCCGTTTGTGATGCCAATCGACGAAGTAGCGAGATCAACGCTTGTTCGGCTGCCAAATCATTTTCAACCATTTGACGACACCGAAATTCTCCATCCGGTTCAGGTGTGAAGCAGCATAGTTCTGCAAGTTTTGCAAAGCTCGCAACTGGAACGCCACCTAATCCATTCAGTCGTTCTCCAATATCGTGAACATGTCCCTGAACCGCTTCATAACCTTCTTCAAAAAATTGATGCAATGAATAGAATTCAGCACCCTCAACAACAAAGTGATGCTTTTGATATTGCAAATACAACGCTTGAAAACTTGCCAATGCAATATTCAAGCCTTCACATACAGGTTCGGTTGTCGATCGATCTAGTAAAATCACGTTATCGGCAACTTGTCCAAAGGGTCTAACTAGCATTTGCGTCATCGGTTTTCTCCCAAGAAATAGATAGCCTTGAGCATTAACATTTTTTGTCTCTAGACAACTTCTTAAGGTCTGTTAGTAACTCTTGGTATGAACGCGAGTCTAACAATTCTCTTTACAAGTCAACTGTCACCTTCATGGAAATTTAAGGTGACAGAAATACAAGTTTCTTTCATCAATCACCCTGTAGAGTGACCCTGAATATAAAGACCATGATGATGGCGTTGTGCAGCTTTTCCTTTTATTACTTTGCCAGTTAGCCCTCACAGTAGACATTAGATGAAAATAACTCTCATGAATCCGTTAACAAATCAACACATTACAGGTAAGAAATAATATGGATATTAATGATTTATCTCAAGAGTTTGAGGAAATCGAAATTGATGGCATCGATCGCTGGTAAATTTATTTTCGGTTGCAAGAATTAGGCATTCCCTGCCGCTGCACCGGTCATGAACCCTTGAAAATTCTAATAAAAAATGCAAACTCAGCAACTCAAGTCTGGAGCGTAGCTAAACATATTGCAATGCACCGCCACGAACTCGTGCAGTGGCTTGAAAACTGCTGGGTATCACATTAACTCAATCAGATTCAGATTGAAGCAGTCTTTGCTCATCTTTACTAGGACACAATGGAGATGACTGGATGTTCATAGAGTGAAATACCCTAACACTGACACTTCAAGGGAACAAATCTTTTGAATAGCAGCAACACAATAGTATAGAGGAATGACAACTATCTCTCGCCTAGTTCGATCTTTACTACTTTTTGCTTTAACGATTCTGTTGGTTTGGGGATGTAACAGAACTCTTTCCACAACTCCACATCTAACCTCAGAACCGATACAACCAATACAGCCAGCCGCGAACTGTCAGTCCATTGAGCACGCCGCAGGGTCAACTAAGATATGTCGTCAGCCTCAGAAAATTGCTGTACTGAGTCCGTATCTGTTGGATATTCTGCTATCTCTAGGTGAACAGCCTGCTGGCTATGCAGGCACCTCCATAGGTCAGGGTCAATTCGATCATCCTGCTCACCAAATTCCTTACTTAGGAAATAGGATTATCACTCAACCTATGAATCTCGGAGATCGTACTTATCCGTCTTTGGAAGCTCTTGCGTCTCTTAAACCAGATTTGATCTTGGGTGAACTATGGCAGGGTAGCCAAGGCAAGTACGACCTGTTTTCACAAATTGCGCCTACAATCCTGATCGACGATCAACAGGGAGGTTGGCAGAGCAATCTTCAACTCATTGCCAAGGCAATGGGGCGTCTCGATGTTATTCAACCGCTGATGTTTGCACGGGAGCAGCGCATGAGTGCAGCGCGTCAGCAATTGAACGCTATCGTGCAGGCAAATCCCCGCATATTGTTATTGAGTTCTGGCGATCTCGCGAATGGTTTTTATGCGTATGGGCAAGACCGGAGCGTTTACTCGGATTTGTTGGAAGCATTGGGATTCAAGATGACTCGCTTGAATGACTCAATGTTGGAAGCGATAGGAGCCGCGCCGCTTTCCCTAGAAATGCTGCCTCAACTTGATACGGATATGCTGATTGTCTTAGGGTGGGATAGTAATCCTAATCAGAATTCCCTCGCCTGGAAACGCCTACAACAGAAATGGAACCAAACACGCCTGTTAAAGGCATTACCTGTATCACAAGCAGGACGAGTGTATTTTATGGATGGTCATTTAACAATGCTGCGAGGCCCCATCGCTGAAGCGTATATTCTGAATGACTTGCTGAAACAGCTTACCTCGAAAATGTGAGTCGGAGAGAAAAAATAATGGTTCCCTTTTTTTGTGCGGATGCTGCCCGGAGCTCGAATGCAGATCTAATTGGTACGGCTTCACCCTACAAAGCTTTTATTGCAGTTGAGTGTCCTCCACCTTGGACTCCGAATGAGCTAGATTCTAAATCCGTTCCAGCTAATCTCAGCACACTTGGGGAATGGGTGAATGAGGATTACGATCGATTTCAGACTTGCCTGCTATTGATCTACAACGAAACCTTGAATCAATCTGGGTTTACTAGACTGCTTATCTTTGAGCAAGCTTCCAACTTTACAAATACCTATCGCCAGCAAGAGTTTCACATCGCTGATCCCAATGAGATTGCCCCACTGATTCAAGCCTATTTAGCAGGTGAGCCTATCGATGTGACTCCGGTTGACAACTCGTTTCGAGATATTTTCGTTTGTACTCACGGGAGCCACGACAAGTGCTGTGCTAAATATGGGTATCCACTGTACCGCGAAGCTACCACGATCGTGAATCATCTATCGTTACATCAGGTTCGGGTTTGGCAAGTGAGCCATATTGGTGGACATCGGTTTGCTCCAACCGCGATCGACCTTCCAGCGGGACGATACTATGGACATCTTAATGGGTCATCCCTCACCTCCATTTTGACGCGAACAGGTGATATTCAGGTTTTAAGACAGGTGTATCGAGGCTGGAGCTACTTGCCTTGGGCAGTACAAGCATGGGAGCGCGAACTACTGTTGCAACAGGGTTGGGAGTGGATGAACTACAACGTTGCAATTCAAGTTTTGGCACAAAATGAAGATGAAACCTTGACTTCGGTAGAATTGACCTTTGAAACACCGGAGGGCGATCGACAGATTCATCGAGCCGACATTATTGCTGACCCCAACAAAGCTGTTTATCTCAAAGGAGAATGTGATAGCGAACAGGCATTTCCATTTCCCCAGTATGAGGTACAGAACTGGATTCGGATCAAGTAACGCTGATGCCCTTACTTGGAGCTATATGGTTCAACATCATGATCGCAGACGGTCGTTTCCATATCGCGCAACGTTGGAATCCAATATCCAATCGCACCCACCAGGACTAAACCGATCGATGAGATGACATACAGGAGTGCCATTCCTGCACCAGATCCGGTTCCAAAAATGCTACCGAATATTCCTGCAAGCCAACCTTCTGGCATCATGGCGGGTTCAAAGATTCGATCTGCCAGTGGTCCAGCCATTAAAGCCGCGATCGTTGAAACAACCAGGAGTAATAGTGAGCGAGTTGCTACAACTCGTCCCTGTCGCTCAGGGCTGACCTTGGCTAGCCAAATTGCATCATTGGAACTACCCAGAAGGGGAAAATTTAGGGAGGAGCAGAATTGACTAGGGAACCAAAGCAATGGTGATTGTCCCAGACCAAATATCGCTTTACTGATTCCTGCGCCAACCATTCCTAGAAGAAAACCATGGATCTTTCGTTTGGGACCTCCTAAGGTGCTCATGATGATCGCACCTATCACTCCACTGACTCCTGCGATCGCAGACAAGCTTGCTAAGACCGATGCATTGTTATTGCTACGCGCTAAAACCATTGCAGAATACAATGACGCACCAATGTCATGGGCAAACCAAAACAGCAAGGCTGCAACTAGGAGCGCAAATAATCCCGGTTGTGCAAACACATAGCGAAAGCCAACCAGCATTTCCTGCAATAGTGTTGTCTGACTTTGAAGTGAGGGTCGAGAAGCAACAGGTTGGGGAATATGAACTCGAAATACGGTCAAAATCGCAATACAAAACGTCAATAAATCAATGAGTAATATACCCAGTAGCCCAATACTGTAATAAAGAATCCCTGCCAGTGCAGGGGCAAAGATATTAGAACTATAATGCAGAACCGATCCCATGCTACTCGCGCGAGTATAGTCCTGCTTGGAAACCATCATTGGGATCGAAGCTGAGTAGGCAATTTCTTGAAGGTCGCTGAAAACGCCATTGATCGCACTCGTTACATAAAAGTGCCAAACTTGTAAATGCCCAGTCAGATAGAGTGAAAGAATGGCGACAGTCGATAGCGCAGCCACTGCATCACTCAACATCATCAGTTTTTTGCGATCGTAGCGATCGACAATGACCCCTGCGAAAGGAGTCACAACAAGACTTGCAACCTGACTAGAGAAAATAATTAGAGTCAGTGCTGTGGCTTGTCCTGTAAGCTGCCAAGCCCACAAAGTAATGGCAAAGTGCGTCATGTAGCTACCAATGGCAGAGACCAATTGACCACTCCAGACGATGACAAAGGTACGCATGGAAATCAGCGAGTGTTGGGTAGATCCAATACTGAGAGAATTTATCAACTATATAGCTTACTCAGCCTACCATCCTTTTGTGAGATCTAGTTTGTTTAGCTGGTTACCTCTGACAATCTTTTAATCAATTTACTCGGCGATATTAGAGATCTAGATTTCCATAAAGGCTTTATATTGCCTGGAATACAGCGGTTATCCGTTCAGTGGAGAAATCCCCTGAACTGAACCAACTTGATCGGGCAATCTCCTTGTACTTTTCATCTAAGCAACTGACAAGCTGATCAAAAAATTTTCAATAGGGCTTGCCAGAGGTAGCAGCTTTGCCGTATGGTAGCCTAGTAATTAATGCAAATTAGTTGCAATAGAGAATTCCATAGTTGGGGTGCTACAGGCACGTAGAGGATGATGAACCACCCTTCAGACGCTTTTCCAGAAACATTTTGGTGTGAATCGACCCTAGTAGCGTTGCTCCGTTACAGGGCGATGCATCAACCCGATCGCTTAGCGTTTACCTTCCTCTTGGATGGAGAAACCGAAGCGGTGAGTTTCACCTACAAAGAACTCGATCGTCAGAGTCGAGCGATCGCAGCTCGGTTACAAGCGATGGGATTGGGTGGGGAACGCGCACTATTGCTCTACCCACCTGGGCTGGATTATCTGGCAGCATTTTTTGGTTGTCTGTATGCGGGAGTGGTTGCGGTTCCTGCGTATCCACCCCACAATCAGCGAAACACACCGCGAATTGCAGCAATTTTATCGGACGCACAAGCTGCGATCGCGCTGACAACAACAGCCATCCTCGACAGAATGCAATCACTGTTGGCTGAGAAAATGAATGGGGATACAATCCAGTGGCTAACCACGGACAATTTGGAGTACTCCATTGCTGAAACTTGGCAGGAACCGCTGATTGAGAACAATACTCTCGCGTTTTTGCAATATACATCCGGTTCGACTGGCACACCCAAAGGGGTCATGCTCAGTCACAGCAACTTACTGCACAATGCTGCTGCGACCTATCGCTACATGGAGCATTCTCCTAGCAGCACGTTTGTCTCCTGGCTGCCTGCTTATCACGATATGGGCTTAATTGGTGGGATTCTACAACCGTTATATGGTGGGTTTCCTTGTATTCTGATGTCGCCTGCTTCGTTTCTTCAGCGTCCTTACCGCTGGCTGCAAGCTATTTCTCGCTATCAAGGCACTACTAGTGGCGCACCCAATTTTGCCTATGACTTGTGCGTGGAGAAGATTACGGCAGAGCAGCGCCAGACGCTTGATCTGAGTCATTGGAGCGTTGCATTTAACGGAGCAGAACCAATTCGGCACAGCAGTCTAGAACGGTTTGCGGCTACTTTTGCTGAGTGTGGGTTCCGTCGAGAAGCGTTCTACCCATGTTATGGGATGGCAGAGGCAACCCTGATGGTTTCTGGTGGAGTCCAAGCTACTGCACCCGTGATTAAGACAGTCCAGAAAGCAGCACTGGAACGTAGTCAAGTTGTAGAGGCTGATGCAGGAGATGCAGAAGTTTGGACGTTGATTGGATGTGGGAAAACAATTCCAGAGCAACATATTGTCATTGTTCATCCTGAAACCCTCGATCGCTGCCAACCCGGTGAAGTGGGAGAAATTTGGGTATCGGGTTCCAGCGTGGGACAGGGCTACTGGAATCGTCCAGAGGAAAGCGCCCAAACCTTTCAGGCGTATCTTTCAGACACCCATGCAGGACCATTCTTACGAACTGGCGACTTAGGCTTTTTGCACGATGGGGAACTGTTCATCACTGGACGCGCTAAGGATTTGATCATTATTCGAGGGCGCAATCTCTATCCGCAAGACCTTGAATTCACGGCAGAACGGAGCCATCCCACCTTGAGAATTGGTAGCAGTGCTGCCTTTGCGATCGCACTCTACGATGCAGAACGGCTTGTTGTGGTACAAGAGGTCGAGTTTCGTCAAAAGCCGAATGTTCAGGAGGTAACACAGGCAATCCGACAAGCGATCGCAGAAGCCCACGAGGTACAAGCCTATGCTGTTGTCTTGATTAAAGCAGGCACGATTCCGAAAACTTCTAGCGGTAAAATTCAGCGTCGGGCTTGTAAAGCAGCGTTTCTGGCAGGCAATCTAGCAGAGATCGGCAGCAGTATTTTAGAGATGGTTGAGGTTGAAAATCTTGAGACATCTCTAACTCGTGCAGATCTCTTCGCATTTGATTCTGCGGAACGCGAAACACAACTGACTGATTATGTTCGGCAACAAGTTGCACGAGTTTTGAGAATTGCAGCAACCCAAGTTGATGTGCAGCACCCTTTAAGCCGCTTCGGACTTGATTCGTTAATGATCTTTGAGATCAAAAGCCGCATAGAGCTTGATTTTGGAGTTGAGATCGCGATCGCGGATTTATTTGAAGGTGCTAGTATTGCCGAACTGGTCGCACAAATTCTAAATCAGCTTACAACCTCAAATCCTCAGTCAGCTTGTCCAATCGTGAGGGTTAAAAGTGCTACAAATTGCTATTCCCTTTCCTTTGCCCAACAGCGATTGTGGTTCCTTGATCAGTTAGAAGCTGCCAATTCTGCTTATCACATTGCGATCGCAGTGCAACTTCAAGGTGAGTTAAATATCACCGTACTGGAGAAAAGCCTCACCGAAATAATTCGACGGCACGAGATTTTACGAACAACCTTTTGCACGATCGCAGGGCAAGTAATGCAGCAAGTCACAGACGCGCAGATTTTGCCATTGACCGTTGTGGATTTGCGATCGTGGGTCAAATCAGAGCAAGAGGTTGAAGCGCAACGCATCACCAAACAGGCAATCCAGCAACCCTTTGACTTGCAGCAAGAACCGCTCTTCCGTGCCACCTTAATGCAACTTGGGCAGGAAGATCATCAGTTGCTATTAACTATGCATCACATCATCTCCGATCGATGGTCGGCGGAGGTCATGCTACAGGAGTTAGCAACACTTTATGATAGCTACTCCCAGGAATGGGTTTCACCCTTGCCGGAATTGCCCATTCAATACGCCGATTTTGCTCACTGGCAGCGAACCTGGCTTCAGGGTGAAGTGCTAGAAACGCAGCTTGCCTATTGGAAACAGCAACTCAACAGTGCGCCAACGGTTTTACATCTTCCGAGCGATCGTCCACGTCCTGCTGCTCAAACCTTTCGAGGGGCAACAAAATCGTTGCATCTTTCTCGATCGCTCACCAATTCGCTCAAGGCACTGGCGCGGCAAGAAGGGGTGACGCTGTTCATGCTGCTGCTGGCAGTCTTCAAAACCTTAATGTATCGCTATAGCGGGCAAGATCGGATTTCTGTTGGCTCTCCTATTGCGAATCGAAACCGCAATGAAATCACAGGGCTAATTGGATTCTTCGTGAACACCTTAGTGCTGCATACTGACCTTGCAGGAAATCCTAGCTTTCGAGAATTGTTGAATCGGGTTCGTCAGGTTGCCTTAGGAGCCTACACCCATCAGGATTTACCGTTTGAGCAACTCGTAGAAGCAGTCCAACCAGAACGAAACATGAGCTATTCGCCTCTGTTTCAGGTGATGTTCACGCTCCAAAATGCTCCACAGCTTCCAGAAATACCGGATCTGGCTCTGAAACCTATCAAAGTAACCAGTGAAACGGCACAGTTTGATTTAAGCGTGGCAGTTGAAACAGTCGAAAACGGGTTAGTTGCAGACTTTGAGTACAATACTGATTTATTTGATGAAAGTACGATCGCTCGGATGCAGCATCACTTTCAAACCCTACTAGAAAGCATTGTCACGAATCCGAATGCTCGGCTCTCAGACTTACCGCTCCTGACCGCGCAAGAGCAACAACAACTTTGGCAATGGGGAAATCAAGCGGTTTCTCTGAATCCCAATCCAGATCTATGTATTCACCAATTATTTGAAGCGCAGGCAAAGCGAACTCCTGATGCGATCGCGGTCATCTTTGAGCAGCAACAACTTACGTATCAAGACCTGAATAATCAGGCGGATCACCTCGCAAATTTCCTCCGCTCTTTGGGTGTTGCTCCAGAGGGACTCGTTGGAATCTGTGCGACGCGATCGCTAGATCTCATCATTGGATTGCTCGCCATTCTCAAAGCGGGAGGAGCCTATGTTCCGCTTGATCCAAACCTCCCGAAAGAGCGTCTCGCTCTGATGCTGGAAGATACTCAAGTGCCAGTCCTGCTGACTCAAACATCCCTGCTCAATATCCTGCCGGAAACGACGGCTAGAGTGGTCTGCCTCGATTCAGCATGGAATCTGAGCGAGCAACAATCTGCCGAACATTGTGCTCCGGTCGCCTCTAATCTGGCTTATGTCATCTATACGTCTGGGTCTACGGGCAAGCCTAAAGGGGTAATGATCGAACATCGTTCCCTCGTGAGTTATATCGAGACGGCAAGCGTTGAATATGGCATCAAACCGGGCGATCGCGTTTTGCAATTTGCTTCTCTGAGTTTTGATGTCGCAGCCGAAGAGATTTTTGTATCCTTGACGCAAGGAGCAACATTGGTGCTGCGGACTGATGCGATGTTGGATTCGGTATCTACCTTCTTGCAACAGTGCCGCGAACTGGCGTTAACTGTACTCGATCTACCGACTGCATTCTGGCATCAAATCACGGTTGAACTGGCTCAAGGGTTGGAATTACCTGAGTCTTTGCGTTTAGTGATTATTGGGGGCGAACCTGCACTGTCTGAGCGGCTTCTGGCTTGGCAAATGAAGGTTCGCGATCGCGTTCAATTGTTGAATGCTTACGGTCCTACGGAAACCACGATCGGCGCTACAATCTGCGATCTATCAACAGTATCCCCTGCAAATTCAGGACGAATTGCCCCGATTGGATATCCTTTGCACAATACGCAGCTCTATGTCTTGGATCAGAATCAACAGCCCGTGGCGATCGGGGTTCCTGGTGAGCTATATGTTGGCGGAGGTGGTATTGCTCGTGGCTATCTAAATCAACCTGAGCTAACGGCTGAACGGTTTATTCCCAATCCTTTCGATCGCAACTCAACCCTTCTCTATAAAACGGGCGATCGCGTCCGCTACCTGCCAAATGGCATGTTGGAATTCCTCGATCGCATTGATGATCAAGTCAAAATTCGGGGCTTTCGGATTGAGTTAGGAGAAATTGAAGCAACACTCCGGCAACATCCAGACGTTCAAGAAGCGATCGTTTTAGCGTGGGCAGATCATTCAAATAACAAACGTCTCACTGCCTACATTCGTGCTGCTACGCCCCCTACACCTATTGATCTGCGTCATTTTCTAGAGGAAAAACTGCCTCAGTACATGATCCCAGCAACCTTTCTCTTCCTGGATGCATTACCCCTCACACCTAGCGGCAAAATTGACCGCCGTGCCTTACCTGCTCCAGAGACGGCTCAAATTGCGTCAACGAGCACTTATGTTGCTCCCAAAACCGAAGTAGAGCAAGCGATCTCTGAAGTTTGGCAAGCGGTATTGCAGATTGAAAAAGTCGGCATTTACGACAACTTCTTTGATCTGGGCGGGCACTCCTTACTGGTACTTCAGGTACAAAGCAAGCTACAAATAGCGTTGAAGCGATCGATATCAGTCACGGATCTATTTCAGTACCCAAACATCAGTGCTTTAGCCAATTACTTGAATCAGACATCATCCTCTAAAGTTTCGTTGCAGGCAGTTCGCGATCGAGCCGCACAACAAAGAGCCGCATTCAATCGACAAAAGCAACTTCGTCAGTCAGGGAAATAGACTTATGAGTAATGTAATTAATGCGATAGAAGGCATCGCGATTGTTGGAATGTCGGGTCGTTTTCCGGGCGCGAAAACAGTCGATGCATTTTGGCAAAACCTACGATCGGGGATTGAATCCATTGCGTTTTTCACCGATGAGGAACTGATTGCGGCAGGCATTGATCCGGTTGTTGTGCGAGATTCTAATTACGTCAAAGCGTCTGCCCTGCTTGATGGGATAGAGCAGTTTGATGCAGCATTCTTCGGCTTCAATCCTAAAGAAGCGGCAATGATGGACCCACAGCAGCGGATCTTTTTAGAATGCGCTTGGGAAGCTTTGGAGAATGCAGGATACGACTGTCAACGCTGCGGCGATCGGATGGGAGTATACGCCGGAGTCGGTTTGAATCAGTATTGGGTCTTTCAGATCGCGCCCGATCGTCAATTGCTAGAATCTGCTGCTGGCTATCAAACGGTCATTGGGAATGAGAAAGATTTTCTAACAACTCGTGTTTCCTATCAACTCAATCTCAAAGGACCCAGCCTTGACATTCAAACCGCTTGCTCAACCTCACTGGTTGCAACCAGCTTAGCCTGCCAGAGCTTACTCAGTTACCAGTGTGATATGGCGCTAGCGGGCGGCATTACAATCCATGCGTTGCAAAAATCAGGCTATTTCTATCAAGAGGGCGGGATTTTGTCTCCCGATGGGCACTGTCGTGCTTTTGATGCCAAAGCTCAGGGAACTGTTCCTGGTAGTGGTGTGGGCATTGTAGTTTTGAAGCGGTTAGAAGATGCGCTGGCAGACGGTGATTGTATTCTTGCAGTGATCAAAAGTTCAGCGATTAACAATGACGGCTCGATGAAAGTCGGTTACACTGCGCCCAGTGTGGAGGGACAAGCAGAGGTTATTGCTGAGGCGTTGGCGTTAGCAGGAATTGAAGCGGACTCTATTTCCTATGTTGAGGCGCATGGGACAGGAACTGCATTAGGAGATCCGATCGAACTCGCAGCCCTAACTAAGGCATTTCGCGATAGTACCGAGAGGAGAAACTTCTGTGCGATTGGCTCTGTTAAAACAAATATTGGGCATCTCGATGCGGCGGCTGGAGTAACAGGTCTAATTAAAACAGTACTAGCACTCAAGCACCAACAAATTCCCCCCAGTTTGTATTTTGAGCAACCGAATCCTCAAATTGATTTTGCCAATACTCCTTTTTACGTCAACACAACGCTCACCGACTGGCAAACGCATCATCAGCCACGCCGAGCCGCAGTGAGTTCCTTGGGCATTGGTGGGACGAATGCACACATTATCTTGGAAGAAGCACCTGCGATCGCTTCGTCTAGCGCTTCCCGCTCTCATCAACTCTTGCTACTTTCGGCTAAAACTGCTTCTGCCCTAAAAACTGCAACGACGAATCTGGCAAATCACCTTCAGCAAAATTCTGACTGCAATCTCGCAGATGTTGCCTACACGCTACAAACGGGTCGCAAACGGTTTGAACATCGTTGCATGGTGGTGGTACGCGATCGTGAGGATGCCATTGAGAGCCTAAGCTCCCTCGATCCGCAACGGAACTTCATCCAATCGGCAGGAGGAGAACGCCCGATCGCCTTTATGTTCCCCGGACAGGGTTCTCAATACGTCAACATGGGACGGGAACTATACGAAACAGAGGCAATCTTTCGCGAACAAGTTGATCGCTGCTGTGAATTGCTCAAATCTCATTTAGGCTTAGATTTGCGATCGCTGCTCTATCCCGATGTCGAAACCGTTGAAACCGCGCAGCGCCTTCAACAAACCGCGATCGCTCAACCTGCTTTATTTGTTATTGAGTATGCCTTGGCGCAACTGTGGCTCAACTGGGGCATTCGTCCTCAAGCTTTGATTGGTCATAGTATTGGCGAATATGTTGCAGCATGTATTGCAGGTGTATTCTCTCTAAAAGATGCGTTAGCGTTGGTCAGCGCACGCGCACAACTAATGCAGCAACTTCCCACAGGAGCAATGCTTGCTGTTCCTCTTTCTGAGCATGATCTACAACCTCTACTAGGTCGCGATCTTTCCTTAGCTACGATCAATAGTGTTACCCAGTGTGTTGTTTCTGGGTCTGAAGCCGCGATCGTAACTTTACAACACCAATTATCGGAACAAGGCATCGAGTCACGTTTGCTGCATACGTCTCATGCCTTTCACTCTCAAATGATGGAAGCCATCGTTGAACCATTCATTCAACGAGTTAAAACCATTCCTCTGCATTCTCCTCAAATTCCCTACATCTCCAACGTGACGGGCACCTGGATTACGGCAGATCAAGCGACAAATCCGGCATACTGGGGCAACCATCTGCGTCAAACGGTGCGTTTTGCGGATGGTATTGACCAGTTGTGGCAAGACTCGCAGCGAATCTTACTCGAAGTGGGTCCTGGACGAACCTTGAGTACCTTTGCTCAACGCCATTCTGCTAAAACAGCAGCACATATAATTTTGACTTCCTTACGTCACCCGCAAAAGCAGCGATCGGATGTGGCATTACTGTTGCAGACCTTGGGGCAACTCTGGCAATGCGGAGTCTCAGTGGATTGGTCAACCTTTTATGCCCACGAGCGACGCTATCGCCTGCCTTTACCAACCTATCCCTTTGAGCGTCAACGCTATTGGATTGAACCGCGATCGTTCTTACAACCAAGCACGACATCGAATCGTTGGGATGAACTGATTCAGGCAGCACAACAACAGGCAAATCAGGGAATTTCAGCGTTAGCAGTTGACCCTTCGCAGGCTCCAAAAGTATTGTCTGCCCTGATGGAGAACGATCCACCCAAGCCAAATCTCCTCGATCGAATCGGGAAGAAGTTGGAGATGGCAGATTGGTTCTATCTACCCTCCTGGAAACGGTCTCTGCCCCCTGCGCCCGTTCAAACCCTTGCATCGAAGTGCTGGTTAGTATTTGTAGATGAGTGGGGTTTAGGTGAGAAATTAGCGCAGCGGTTGAACCAATCGGGTCAAACGGTTGTGATGGTTCGAGCCGGAACACAATTTCAGAGGTTACACAGCCTCGTAGAGCAAAATTCGGTCAATTGCCACTATACAATCGCGCCTCACCGTCCCGGAGACTACCGCACGTTGCTGGATGATTTGCGAACCCTGGGCAAACAGCCAGAAGCGATCGCGCATTTGTGGAGCGTTACGAACGAGACGAATTCATCTCTAGAATCCCTAGAGCAAACGGAAACTCTGAGCTTTTTCAGCCTGCTATTTCTAGCGCAAGCTCTTAGTGAGCAGTCTTCAGATTGTGCCATTGACATCAACATTATCTCCAACCAAGTACAGGACATCGCGGGTTCCGAGGAACTATGTCCTAGCAAAGCATTGTCTCTTGGACCTTGTAAGGTGATTCCACAGGAGTATCCCAACTTCACTTGTCGCAGCATTGATGTGGTGCTTCCGGTTCACAACCAAGATGAAAAGTTAATTCAACAACTGTTTGTAGAACTGACTACGCCATCCTCTGATCAGACGATCGCCTATCGAGGCAATCATCGTTGGGTGCAGACTTTTGAAGCTGTGCGTTGGGATAACACCCGCTCCTCTCGTTTACGGGATCAAGGCGTTTACTTAATTACAGGTGGATTGGGAGGTCTGGGACTCACGATCGCAGAATATCTCGCTCAAACTGTGCAGGCAAAATTGGTGCTGGTAGGACGATCGCCATTTCCTGCCAGAGAGGAGTGGGCACAATGGTTGGCGACGCACGATCGCCAGGATGAGACGAGTCTCAAAATTGAGAAGCTTCAGGCGTTAGAGAGATTGGGTGCAGAAGTGTTGCCTCTGAGCGCAGATGTATCAAATTCAACGCAAATGCAAGCCGTTTTGACGCGCATCAATGAGCAATTTGGGCAACTTCATGGGGTGATTCATGCGGCTGGGGTCACACCGGGAGGCATGATGCAAACTAAAACTGCCGAAGCTGCCGCTAGGATTCTGACCCCCAAGGTGAAAGGAACGCTGGTGCTAGCAGATCTGCTGAAGAATACGCCACTAGACTTCTTGGTGCTGTGTTCGTCCCTAACTGCAATTCTGGGCGGTTTGGGCATGGTGGATCACTGCGCTGCCAATGCGTTTTTAGATGCTTTCGCCTATCATCATCAGATTCAATATCCCGATCGTCTTACCGTTTCCGTTAACTGGGATAGCTGGCAAGAGGTCGGACAGGCAGCCAATACCATCATTCCAGCAACGCTTAAACAGGTACGCGAAGAAAATTTAAAGCAAGGGATTTTACCGCAAGAAGGGATAGAAGCTTTCTGCCGCATTTTGCAATGCATGGTGCCTCAAGTCCTGGTTTCAACACGCGATTTTCAGATGCAGTTACAGTACGATCATCTGCTGAATAGTGTGGAACATCTCGAACCTGTGAGGCAGGATCTGCACCCTAGACCAGCGTTGAGTAATGCCTATATTGCTCCTAGCAGCGCGATCGAACAAACTGTTGCAGAGATTTGGCAAGAGTCATTGGGAATTGAGTCGATCGGCATTCAGGATAACTTCTTTCACTTAGGCGGAGATTCCTTGTTAGCCGTGCAGATTGTCTCCCGATTACGAGATGCTTTCTCGGTTGAGTTATCACTGCAAACCCTTTTATCAGATGCCCCAACCATTGCTGAATTATCGAAGACGATTCGCACTCTACAAGCAGAAACAAATGAGCTTGACGTAATGAACGAACTGCTATTAGAGATAGAAAGTTTATCGCTGAGTGAAATTCAAGAACAACTGGAAGCAGCACAATTCAGTAATCATTAACCACGACACTCTGTAACATAACAAATCCTATACGGCTGGCAAAGAATGAACACGCTCTCTCAACGTCTCGCTGCTCTCTCACCGGAACAGCAGAGGCTTCTAGAACTACGTCTCAAGCAAAAAGGCTTAACGGCTCCTAAAGCCCAATCCGTTATTCAGCCTAGACAAAATCAGGACTCACTGCCCTTATCTTTTGCTCAAGAGCGGCTGTGGGTGTTGGATCAATTGCAGCCAGAAGTGCCGTTTTATAATGAAGTTCATTTCTTTCACCTGCGGGGGGCGTTGAATGTAGCGGCATTAGAGCAGGGTTTTAATGCTATCTCACAGCGCCATACTGTGTTGCGGAGTAGATTTGCGACTGTTGAGGGACGACCTGTTCAGCAGGTAGAGCCGTTTCAGCCTTTCCCTTTGCCGATCGTCGATCTGAGCCAAGCGGCAGAAACAGAGCGGGAGAGCGTTGCGAGAGCGATCGCGACTCAAGAGGCGCAGCAACCGTTTGATTTAGCCAATGATGTGTTAGTGCGAATTAAGCTTCTGCGGCTCACGCCAACGCATCACATCTTGCTGCTCACCGTCCATCACATTGTCTGTGATGGTTGGTCAGTCGGCGTGTTCATTCAGGAACTGGTCAGGTTCTACACTGCCTTTGCTACGGGGGAACCGCTCTCCCTTGCTAATCTGCCAATTCAATATGCAGATTTTGCGGCTTGGCAGCGAGAATGGCTCCAAGGTGAAGTGCTAGAGACTCAACTTGCTTACTGGAAACAGCAACTCGGTGGCACATTGCCCGTTCTAGAACTTCCCACAACCCGTCCGCGTCCTACCACGGAAACTGGACGAGGTGCGATTCAAACCTCATCTTTATCACCCGCCTTAACCCAAGCGCTCAAGACACTGAGTCAGCAAACAGGGGTGACGCTGTTTATGACTCTGCTAGCAGCTTTCAACACTCTGCTCTATCGCCATACCAGAATAGAAGACATTTTGGTGGGTTCGCCGATCGCAACCCGCAATCGGGTTGAATTAGAAGGCTTGATCGGGTTATTTCTCAACACGCTTGTATTCCGCACTGATGTTTCTGGCAATCCGACGTTTCAGGAGTTGCTCAATCGGGTGCGTGATGTCGCACTCGGAGCCTATGCCCATCAGGATGTACCGTTTGAAAAACTGGTTGAGGAACTGCACCCTGATCGCAACCTCAGCCAATCCCCGTTGTTTCAGGTGATGTTCATTCTGCAAAATACGCCCAAACCCGCCTTAGAGCTACCTGGTTTGACGATCGAACCCTGGGATATCGATAACGGAGCCGCGACCTTTGATCTCACGCTCAGTCTGCAAGAGACCTCTCAAGGTCTTAGCGTGAGTTGGGAATACAACACTGACCTGTTTGATGCAGATGCGATCGCGCGAATGCAAGGGCACTGGCAAACCTTGCTAGAAGGAATTGTGAAAAATCCCCAAGCTCGCCTCTCAGAATTGCCTTTGTTGACAACCCAGGAACTAGAGCAGCTTTGGACATGGGGAACCGGAGAACACGAAAGCCATGCTCTCGTAGGCACCCCGCAACATCTATGTATTCATGAATTATTTGAGGCGCAAGTTGAACAAACTCCCGATGCGATCGCGGTTGTTTTTGAAGATCAACATCTTACTTATACCGAACTCAACCACAAAGCCAATCAACTAGCCCATCAGTTGCGATCGTGGGGTATCCAACCGGAAATGTTGGTAGGGATCTGCATGGAAACCTCACTAGAGATGATGGTGAGCATTTTCGCAATCCTCAAAGCCGGAGGCGCTTACCTGCCGCTTGATCCTGCCTATCCGACAGAACGGTTAGCCTTCATGCTCAATGATGCGAAAGTATCGGTGCTCCTGACGCAAACTCATCTGCTCAACACGCTCCCTCAGCATCCGGCTCAGGTTCTTTGTGTCGATCGCGATCAATCCATTTCTACGGCTGCCTCCCTGTCTCCTGCACCTACTGGCTCAAACCTTGCCTATGTGATCTACACGTCTGGTTCTACGGATACCCCCAAGGGCGTGATGGTCACGCATCGCAGTTTGGTCAATGCCTATTTTGCATGGGAAAGTGCTTACCAGTTGAGAGCGGCTGTCACCTGTCATCTACAAATGGCAAGCTTTTCCTTTGATGTTTTTTCTGGCAATTGGATACGGGCACTGTGTTCTGGGGCAAAGCTCGTGCTCTGTCCTAGAGATTTTTTACTAATGCCTGATCAGCTTTACAGTCTTATGCGTCGGGAGCAGGTAGATTGTGCAGAATTTGTACCAGCCGTGTTGCGGAATTTACTCAGATATCTAGAAACAACGGGTCAATCGCTCGACTTCATGCGGCTCCTGATGGTGGGGTCGGATAGCTGGTATGTACAAGAGCATCAGGCTATCCAGCGATTGTGCGGAACCCAGACTCGGCTGATTAACTCCTATGGTGTGACTGAGGCAACGATCGACACAACTTATTTCGAGAGAACTGAGACAAAACTGTCTGTCGATAACTTAGTTCCGATCGGTCGTCCCTTTCCGAACAGTCAGGTGTACGTTCTGGATATCGATCGACAACCTGTACCAATTGGAGTGCCTGGAGAACTTTACATTGGGGGTGCTGGCGTTGCACGAGGATATCTGAATCGTCCTGAACTGACCGAGGAGCGGTTTATCCCTTACGTTGACCCTTTCACTCCTTCAATTACAACTCGTTTATATCGAGCTGGCGATCTGGTTCGCTATCTGCCTGATGGCAATCTGGAGTTTTTAGGACGGATTGATAACCAGGTAAAGCTGCGCGGGTTTCGTATTGAGCTAGGAGAAATCGAAGCAACCCTTGGGCGATCCCCTACTGTTGCAGAAACAGTTGTCGTGGTGCGAGAAGACGAACCTGGACACAAACGATTAGTTGCCTATGTTGTTCCTGTGCAGTCAACCAGTTTCTCACTTTCTGATCTTCGCAACTTTGTCAAAGACAGATTGCCGGGGCACATGGTGCCGTCTGCGTTTGTGGTGTTGGAGTTCCTACCGCTCACACCTAACGGCAAGATCGATCGACGATCGCTGCCTGTTCCTGAGATAGCAAGACCGAATTTAGAACATACATACATTGCACCTCAAAACCCAGTGGAAACGGCATTGGTCGGTATCTGGGCTGAGATACTTGGGGTGGCGCAAGTGGGCATTGACGACAACTTCTTTGAGTTGGGTGGCGATTCTATTCTGAGTATCCAAGTAGTCGCTAAGGCAAATCAGCAGGGATTGAGAATGACACCCAAGCAGGTGTTTCAGTATCAAACGATCGCAGAGTTAGCCACCGTTGTAGAACTCGTAGACGCGCAGACCATCGCTCCAGCAGAACAGGGAGCGGTGACAGGTGATTTACCACTCACGCCCATTCAACATTGGTTCTTTCAACAGGAATTGTTGGAGCCGCATCACTGGAATCAATCCATCTTGTTAGAAGTCCGACAAGCGATCGATGCCAGGCTTTTAGAAAAGGCAGTCCAGCATTTACTCACTCATCACGATGCATTGCGACTGCGATTTTCTCGGACTGCTGAAGGTTGGCAACAGCAGATGATCAGCCCCGATACGGCTGTTCCATTCTCCCAAGTGAATTTGTCAAACCTGTCTACAGCAGAACAAGCGATCGCGATTGAGCAAGCAGCAACACAACTCCAAGCAAGCCTTAATTTGAGCGATGGTTCGATCGTGCGGGTTGCTTGGTTTGACCTGGGACTCCATCGAGCGAGCCGTTTGTTGATTGTGATTCATCATCTTGCAGTCGATGGGGTGTCTTGGCGAGTGTTGCTAGAAGATCTGCAAACGATTTACCAGCAATTGAGAGATGTTCAACCGATCAAACTGCCGGCTAAGACCACTTCATTTAAACGGTGGGCAGAACAGTTGGTTAACTACGCACAATCGGAAAGTTTGCAACAAGAACAGTCCTTCTGGCTAACCCAATTGCAAAAGCCGATTCCGCCCCTCCCTGTGGATTTTCCAGGCGGAACGAATACCGTTGCCCAAGCTCGTACTGTCACCGTAACGCTGAATTCAGCAGAAACCCAAACATTACTACAAGACGTACCTGCTGCTTATAGCACCCAAATCAACGATGTGTTGTTAACTGCACTCGTACAAGCGTTTGCAGCGTGGACTGGAAAACCATCACTACTGGTGGAGCTAGAGGGACATGGACGCGAGGACATGATTGAAGGGGTAGATGTATCGCGTACGGTCGGCTGGTTTACTGCTGTGTTTCCAGTATTGCTGGAGTTGGATAGCAGGGTTGATAGTGCCCAAGCCCTAAAAGCGGTGAAAGAGCAACTGCGGCAAATCCCGAATCGAGGCGTTGGCTATGGACTGCTGCGCTATCTCAATTCAGGAGAAATCGCTGAATCCTTGCGAAAACTGCCTCAAGCGGAAGTCAGTTTCAACTATCTCGGACAGTTTGATCGGAGCTTTGCAGCGTCCTCTTTGTTTGGGCTGGCTCAAGAGTCGAGCGGCTCTTGTCATGGCTTGCAAGATCGTCGATCGCATCTATTTGAGATTGACGGCATGATTACCGACGGTCAGCTGCAAATGGTCTGGACGTATAGCGAAGCATTGCATCACCCTGCCACCGTTGAAGGACTGGCACAACGGTTTCTCGAAAAGCTGCGATCGCTGATTTGCCACTGCCAATCGCCTGACGCTAAAGGCTATACCCCCTCAGACTTTCCCCTAGCCGAGCTTAGTCAGGATGAACTTGATGCCGTATTCGCGACGGTTGAATTTTCTGTTGAATTTTCAGGGAGATAAGCCACCATGAGCGCCAAAAACATTGAAGACCTCTATCGTTTGTCTCCGATGCAGCAGGGAATGCTGTTCCATAGCCTCTATGCACCAGAATCAGGGGTGTATGTTGAGCAGGTCAGTGCTGAGTTACAGGGAGATCTGAATATTCCAGCCTTTGAGCAGGCATGGCAGCAAGTCCTCGATCGCCATCCGATTCTCCGCAGTGCTTTTGTTTGGGAGAACGTAGAAAAACCGCTGCAAGTAGTGGGACGGCAGGTCCATTTACCTCTGATGGTTCACGACTGGCAAAAGCTCACGGTGGCAGACCAGCAAGCCAAGCTGGAGGCATTGCGCCAAGCTGAGCGGATGCAGGGCTTTGAATTATCAAAGGCTCCACTGATGCGGTTGATCCTGATTCAACAAGCAGCGCAACAGTATCATTTTCTCTGGAGCCATCATCATTTGCTATTGGATGGTTGGTCTACGTCCCTGGTCTTGCAAGAAGTCTTTGTGGTTTATGAGGCAACTTGTCAGGGTCAAACCTTGCGACTGCCCAAGCCCCGACCGTACCGGGATTACATTGGCTGGCTGCAACAACAGTCTTTACCTGAAGCAGAGACATTCTGGCGGCAAACGCTCAAAGGTTTCACGGCACCCACTCCTTTTGGGGTAGATGTCGATCACTCTACCTCTGCCATCCAGGTTGGGGAATATCACACGTCCCTCGCAAGCGAAACAACCACAGCCTTACAATCGCTGGCACGTCAGCATCAATTGACGCTCAACACCCTAGTTCAAGGAGCTTGGGCATTGCTGCTCAGTCGATATAGTGGCGAGTCGGATGTGGTGTTTGGCACGACGGTTTCAGGTCGCCCGACGACCTTACCAGGGGCTGAAGCGATGGTGGGATTGTTCATTAACACCTTGCCGGTACGAGTACAGGTGCAATCGGATCGATCGCTTCTTCCCTGGCTCCAGCAGTTTCAATCGCAACAGGCAGAAGCACGACAGTACGAATACACGCCGCTTTTCCAGATTCAGCAGTGGAGCGAGATTCCACCCAATTCGCCCTTATTTGAGAGCCTTGTCGTTTTTGAAAACTATCCGATCGATCCAAACGTTGAGCAGGGCAATGCTGACTTAATCGTCAGTCGAGTTCAGGTGTTTGAACAAACGAATTATCCGCTGACGGTGATCGTTCGACCGGGTGCTGCGCTAGAAATTAGCTTGGTTTACGATCGTCACCGTTTTGATGCAGACACGATCGCTCGGATGGCGGGACATCTGCAAACCCTTCTGGAAGGAATGGCAGCAACCCTCGATCGTAGTCTCTGGGAATTGCCTTTACTCACCGCAGCAGAGCAGCATCAGCTTTTGGTGGAGTGGAATCATCCTCAAGGTACGGATTTAGTAACGCATTCTCAAACTGCCTGTCTGCATCACTTGTTTGAGGCACAAGTCGAACGAACTCCGAATGCGATCGCACTGGTCTATGAGGATCAGCAGCTCACCTATCGCGAACTGAACGATCGCGCCAATCAACTCGCCCATTACTTGCAATCGTTAGGAGTTACACCTGATGTTTTGGTGGGGATTTGCCTGGAGCGATCGCTTGAAATGGTCGTGGCGTTGCTTGCCGTTCTCAAAGCAGGAGGGGCATATCTACCTTTAGACCCATCCTATCCACCAGAGCGTTTAGCATTCATGATCGAAGATGCTCAGGTGCCTGTGTTGCTGACGATGGCAGGACAACAGAATCAATTTTCCACTCCAGCAGCCAAGGTGGTTGACCTCGATCGCGATGCTGCTATTCTGAGCCAGCAGAGCATCGAGAATCCAGTCGGCGAAGTCACGCCCGATCACCTCGCGTATGTGATTTATACCTCCGGCTCCACTGGAAAACCCAAAGGTGTATTGATTCACCATGCCAATGTTGTGCGGCTCTTTGCCGCCACTCAGCCCTGGTATCACTTCAACGAGCAAGATGTGTGGACACTCTTTCACTCCTATGCATTCGACTTCTCAGTGTGGGAAATTTGGGGGGCTTTGCTGCATGGTGGGCGACTGGTTGTGGTGCCCTACTGGACGAGTCGATCGCCCGAAGCATTCTATGACTTGTTGTGCCAAGAACGAGTGACGGTACTGAACCAAACGCCTTCCGCCTTCCGTCAACTGATTCAGGTCGAAGACTCCCTCCGTCGTCCGTCTACCCTTTGTCTGCGTCTAGTGATCTTCGGTGGAGAAGCGCTGTCCTATCAAAGCTTGCAGCCCTGGTTTGAGCGACATGGTGATCGATCGCCGCAGTTAGTGAATATGTACGGCATCACCGAAACGACGGTGCATGTGACCTATCACCCACTGACCATGGCAACGCTTGGTGAAACCAGGAGTGTGATTGGCAAACCCATTCCCGACCTTCAGGTGTATCTTCTCGATCACCATCACCAACCTGTACCCGTTGGGGTTCCGGGTGAAATGTACATTGGAGGCGCGGGTCTAGCACGGGGCTATCTCAATCGTCCGGAACTCACTGCCGAGCGCTTCATTCCCCATCCGTTTGACGATGCGCCAAACGCACGACTGTATAAATCGGGTGACTTGGCACGCTATCTGCCGAATGGCGAGATCGAATATCTCGGTCGGATCGACCATCAAGTGAAACTGCGCGGTTTTCGCATTGAACTCGGTGAGATTGAAGCGCTGTTGTGCCAATATCCGCAGGTGAATCAGGCTGTGGTGATCGATCGCGAAGATGTGCCCGGAGATCAACGCCTCGTGGCTTACATCGTTCCTGATTCCACCCTAAACGATGCACAACTCATCGACCTCCGCCATTTTCTGCAAACCAAACTTCCAGACTATATGGTGCCCGCTGCTTTTGTGGTGCTGGACGCCCTGCCTCTGACGGTGAATGGCAAACTCGATCGTCGGGCATTACCGGTTCCCAATGATTCTGCCTTGGCATCAGACGATCGCACTACGGCACCGCGCACACCCGTTGAAGAAATGGTGATGGGCATCTGGGCAAAGGTGTTGGGACTGAATCAGGTAGGACTTCACGACAACTTTTTTGAGTTGGGTGGTCACTCGCTGCTAGCAACTCAGGTGACCTCGCAAGTCCGAGCGGTGTTTCAAGTGGAGCTACCCTTGCGGTGTTTGTTTGAAGCGCCTACGCTCTCTGCATTTGCTAGGGAAATTGAGTTCGCAATTGGTACAGATCGTTCCTTACAGGCTCCGACGATCGATCGAGTCTCCCGATCCGAGCCTCTGCCCCTGTCCTTTGCTCAGCAACGGCTGTGGTTTTTGCAACAGCTTGATCCGAATGACACGTCCTACACCCTACCTGCGGCAGTACGGCTGCAAGGACGGCTTAATATTGCCGCGCTAGCGCAAAGCTTGAGTGCGATCGTGCAGCGTCATGAAATTCTGCGATCGCAGTTTGTCACGATCGCAGGACAACCCACTCAGGTGATTCTCCCAGAAGCCACCGTTCCGTTGATCCCGATAGATTTGCAGTCTCTATCGCCATCGGAACAAGATGCGGAAGTCCAGAGACTGGCTCTTCAAGCAACCCAGCAACCCTTTGATTTGTCCCAGGCTCCACTACTGCGATCGACCTTGCTGCAACTCGCAGAAAACGATTTTGTGCTGCTCCTGACGATGCATCACATTGTTTCGGATGGATGGTCGATCGGCGTGTTCATTCAAGAAATGGTTCAACTCTACACTGCTTTTGCTGAAGAACAAGCCTCGCCACTAGCAGCATTGCCGATTCAGTATGCCGATTTTGCCCTGTGGCAGCGGCAGTGGTTACAGGGAGAGGTTCTAGACGCTCAACTGGCTTACTGGAAACAGCAATTAGCCGGTGATCTGCCGATTCTGGAATTGCCGAGCGATCGTCCTCGTCCTGCGGTTCAGAGCTTCCGGGGCGCAACTCGATCGTTCCAGCTTCCCCGCGATCTATCCACAGCTCTGCAAGCCTTCAGCCAGCAACAGGGCGCGACCCTGTTCATGACCTTGCTGGCAGCGTTTAAGACCCTGCTCTACCGCTACACCCAACAAGCAGACATCTTAGTGGGATCGCCGATCGCAAACCGTAATCGGGCAGAACTCGAAGGATTGATGGGTTGCTTTGTGAACACACTGGTTTTTAGAACGAATCTATCCGGCAATCCGAGCTTTCAGACGGTGTTGAAACGAGTTCGGGAAGTCGCTTTGGGCGCGTATACCCATCAGGACGTGCCGTTTGAGAAGCTAGTCGATGAACTGCAACCCGATCGTGATCTCAGCCATCATCCGCTCTTTCAGGTGATGTTCGTGCTGCAAAACGCTCCGATGCCAGCCCTGGAGCTTCCCGATCTCACTCTCAGCACACTAGATATCGACAGTGGGACGGCTAGCTTTGACTTGACCCTGAGTTTGATGGAAACGCCCACAGGACTCAGCGGCAGTTGTGAATACAACACGGATTTGTTTGAGCCAGAGACGATCGCTCGGATGCTGGAACAGTTCCAAACTCTGCTCGAAAGCATGATTGCGAATCCGAAGCAATCGATTTCGGATCTGCAACTGTTACCAGAATCGGAACTGCACCAGCTTCAGGACTGGGGAACCGGAGAAATCGTAAGCAATGCGTCATCGCCTTTATGCCTGCATCAATTGTTTGAAGCTCAGGTTGAGCAAACACCGGATGCTATTGCCCTGCAATGGAATGATCAACACCTAAGTTATCGGGAACTGAATGATCGTGCCAATCAACTCGCAAGCCATTTGCAGTCTCTAGGAGTTGCGCCTGAAGTGCTGGTTGGAATTTGTGTCGATCGCGCTCCAGAAATGGTGATCGGTATTCTCGGAATTCTGAAAGCGGGAGGCGCTTATGTGCCGATCGATCCGGGCTATCCGCAAGATCGCATTGCTTTCATGCTAGAAGATGCCCAAGTCTCAATCTTGCTGACTCAAGCTCATCTGCTCGACACTCTGCCTGCTTGTCCTGCCACAACGATTTGCCTGGATACTCTCGATACGATCGCGGTACCACTTGCACTTTCTAGCCTTGCATCACCCACGAGTCTTGCCTATGTGATCTACACCTCTGGCTCGACAGGCAAACCCAAAGGTGTACTTGTCGAACATCAAGCCATTTGTAACCGTTTACTGTGGGGGCAAACGGTCTATCAGTTGAATGGGCGCGATCGGGTTTTACAAAAAGCCTCCTTCGGTTTCGATGTGTCGATTTGGGAAATCTTTGGGGCGTTAATTGCTGGAGCAACCCTGGTTCTGGCTCCAGCCGATGTTCCTCAAGATAGTGCAGCACTCGTTCAGTTCATCGCTCAACATCAAATTACGGTTGTAGATTTTGTCCCTTCGTTACTGCAAGTGTTTTTGCAGATGGAAGGCTTAGAAACGGCGTGCCGCAGCCTACGCTACATTACCTGTGGGGGTGAGGCAGTCAGTGCCCAACTGCAAGCACAATGTTTTGCCCGGTTGCCTCATGTGGAACTGCACAATCTCTATGGACCTACTGAAGCCGCGATCGATGCTACTTGGGAAGTTTGCCAACCGACAGATCAACAAACCGTCTCGATTGGTCGCCCGATCGCCAATACGCAGATTTATTTGCTCGATGCCAATCTCAAGCCTGTTCCCATCGGGGTTCCGGGTGAACTCTATATTGGTGGGTTCGGACTGGCTCGCGGCTATCTCAATCGACCGGAGTTAACCGCAGAACGATTCATCCCCAATCCTTTCTGGGGAGATCGAGATCAATCCTCAGCCCGCCTTTACAAAACAGGCGACTTAGCCCGTTGGCGATCGGATGGCAAAATCGAATTCTTGGGACGCATTGACCATCAAGTGAAGATTCGAGGATTTCGGGTTGAACTTGGTGAAGTTGAAGCTGCGCTAGAACAACATCCAGAGATTCAGCAAGCGATCGCAGTGATTCGAGAAGATGCCCCCAATCGCAAGCAACTTGTGGCTTACGTCGTTGCCACGCTTCCCGATGCTGCCCTGGGTTCCCTGCGTTCATTTCTTAAAAACAAGCTGCCGGACTACATGCTTCCTGCCGCCTTTGTGCAGTTGGAATCTCTGCCCCTAACGCCCAATGGTAAGGTGGATCGCCGTCATCTACCCGCCCCCGATCGCACTCATCTCGCAACGAAAACGCCACTGGTTACGGCGAGCCACGCGATCGAGCAGCGGTTGACTGAAATTTGGCAACAAGTTTTGGGCGTTGAGTCGATCGGTATTCATGACAATTTCTTTGAGTTGGGGGGCGACTCCATTCTCAGCATTCAAGTTGTGGCTAGAGCGAATCAGGAAGGCTTACGAATGACACCCAAGCAACTGTTTCAGCATCAAACGATCGCTGAACTTGCTCAGGTTGTCGATACCGAGCAGGCAGTGCAAGCAGAACAGGATGCCGTCAGCGGAGAACTACCGTTAACACCGATTCAGCACTGGTTCTTTGAGCAAGCCCTAGTCAATCCACACCACTACAACCAGGCAACGCTGCTCGAAGTCCCCGCTACTCTAGAGGGAAGCCAAGTTCAACAGATTGTGCAACAGTTACTGATCCATCACGATGCCCTGCGGCTGCGGTTTGAGCAAACCGAATTGGGGATTCGGCAAGTCAATGCACTGCCAGAAGAGACGGTGCCATTCGTTCAGGTCGATTTGTCAGCGATTCCTGAATCAGAGCAAGCTGAGGCAATCACTCAACACTGCGAAGAACTACAAGCTAGCCTCGATTTAACATCCGGTTCGCTCGTACGAGTTGCCCTCTTTAAGCTCGGTGCAAACAAACCGGGACGATTACTTATTCTGATTCATCACTTAGCAGTGGATGGGGTGTCCTGGCGAATTTTGCTAGACGACTTCCAAACTGCCTATGCCCAACTTCAGCAGGGGCAAGCAATTCAGCTTCCGGCAAAAACCACATCGTTTCAGCATTGGTCGCAACGCTTAACGGACTACGGACAGTCAGTGGCAGTGCAGCAGGAGTTGGAGTATTGGTTAGCTGCCCATCAACTGCCTAGTTTTTCTTTGCCGATCGACGATCCGAAGGGCATCAATACGATCGCTTCAGCTAACACAATCACCGTTACGCTCACCGCAGCAGAGACTCAAACGCTTCTGAAAACAGTGCCAGCAATCTACCGCACCCAAATTAACGATCTATTGTTATCGGCATTGGGTCAAACATTTACCCAGTGGACAGGTCATCCACTTCGGGTCGATCTAGAAGGTCACGGGCGAGAGCAACTTTTCTCGGATGTAGACCTGTCTCGCACGGTCGGCTGGTTCACGTCCATCTTCCCGGTGTATCTAGATTTAAGCAATGCAGATGGAATGGAGGATGCCCTGAGAACAGTCAAAGAGCAGCTTCGTCGCATTCCCAATCAAGGAATTGGCTGTGGCGTGTTGCGCTATCTCGCGCCAGCGGAAATTGCTGCACAACTCAGGGATTTGCCACAGGCGGAGGTCTGTTTCAATTACCTAGGGCAGTTTGATACAGCACTCGACGCGACGACCACCTTCAAGCTTGCTAAAGAATCGAGTGGTGCGGTTCACTGTCCCGAAGGAATTCGTCCCTATCTATTAGAAATTGATGGCTTCATTGCTGCCCAACAACTGCATCTGGAATGGAGCTATAGCTCTGCGATTCATCATCCAGCCACGATCGCGCAGTTAGCCGAAGGGTTTATAGAGGCATTGCGATCGATTATTGCTCGCTGCCACTCCCCGGAAGCGGGAAGCTATACCCCTTCTGATTTTGAGGCAGCCAAAATCAGCCAAAAGGACTTTGACAAATTGTTGGCAAAACTCAGCCAAACTGGGAGACATTCTTCATGAAAATGGACAATCTAGAAGACATCTACGAACTTTCGCCACTTCAGCAGGGCTTACTGTTTCATACGATCTATGCGCCACAGTCCGGCGTGTATTTTGAGCAGTTTAGCTGGACGCTCAAGGGCAATCTGAATGCAACCGCGCTTCGGCAAGCTTGGCAGCGTGTGGTCGATCGGCACTCAATTTTACGCACTGCCTTTTACTGGCACGACTTGGAAAAGCCTTACCAAGTCGTGTATGGGCAGATCGACCTCCCTTGGCACCAGGAAGATTGGCGACACTTTGATCCAGAGACACAGCGCGATCGCTTAGATGAATTTCTCAGGGTCGATCGCCAAACAGGATTTGAACTCTCCCAAGCTCCCCTGATGCGCTTGGCACTATTGCGTTTAGCTGATGATGCCTATCACCTTGTCTGGAGTAGTCACCATTTGCTGTTAGATGGCTGGTCAGAGTCGCTGATCTTCAAAGAAGTGTATGCCTTCTATGAAGCATTTTGCCAGGGACAAGACCTGCACCTGAGCCAACCGCGCCCCTTCCGTGACTACATTGCCTGGTTGCAGCAGCAAGATCTCGCTCAGGCGGAGGCATTTTGGCGGCAGAGGCTCAAGGGGTTCACTGCACCGACTCGTCTTGCGGTCGATCGCAACGCTCACAATTTACCTAGCCAGGAAGAAGATTATGACTGGCAGCGCATCGATTTGTCGGAAGCGACTAGTATCGCGCTCCAGGATCTAGCACGACAGCATCAACTCACACTCAACACCCTAGTCCAAGGTGCTTGGGCATTACTGCTCAGCCGCTACAGTGGCGAGTCTGATGTGGTCTTTGGCGTTACGTCCTCCGGTCGCCCGACGGACTTAGCCGGAGTCGAGTCAATGGTGGGGATTTTCGTCAACACGCTGCCCCTGCGCGTTCAGGTTCCTCCCGATGCCTCTCTGCTGCCCTGGCTGCAACAGATTCTGGCTCAACAAATGGAGGTGCTTCAGTATGAGTACAGTCCACTGGTACAGGTGCAGGGCTGGAGTGATGTCTCTCGCAACCAACCTCTGTTTGAAACCTGTCAAGTTTTAGAAAACTATCCCGTTGATGCCACGGTGAAAAACGGCGTTGAGGGGTTTGAGATTCAGAATCCACGATCGTTTGAGAAAACCAATGAACCTCTCCGATTGCTAGCGATTCCTGATGCGGCACTGCGGCTTGAGCTTTGGTATGATACGCGCCGCTTCGATCGAGCAACGATCCATCGAATGCTTGGACATTTGCAGACGCTCCTAGAAGGCTTTATCGCCCATCCTGAAGCGTGTCTCTCAGCGTTACCGATGCTGAGCAATGAGGAATTGCAGCAATTGAAAGTATGGGGAGAAGGAGCGGTTCAGCCGGCATCGGGCGAATGTATTCATCACTTATTTGAAGCACAAGTCGATCGCACGCCTGACAATATCGCAGTCATTTGTGCAGACCAGCAATTGACCTACCGAGAACTCAACGATCGGGCAAATCATCTGGCTCATTCTCTGCAAACCCTGGGTGTCAAGCCCGAAACACTCGTGGGGATTTGTGTAGAGCGTTCCTTAGAAATGGTCGTGGGCGTTCTAGCCATTCTCAAAGCAGGAGGGGCTTATGTACCCCTCGACCCAACCTATCCGGCAGAGCGGGTAGCATTCATCTTGCAAGATGCTCAGATATCCGTCTTGCTGACTCAGCAAACGCTTCTTTCCACGCTGCCTGACACCCCTGCCCAAGTGGTTTGCCTCGACGCGAAGACAAATTTTCCAGAAACTTTAGAGATCAATCAAAATCCACAATCTGCAATCACTCCCGCGAATCTCGCCTATGTCATTTACACCTCTGGTTCAACAGGTCAGCCAAAAGGTGTCGCCATTGAACATCGAAATACGATCGCGTTACTCCACTGGGCGCAATCCGTTTTCACTGCCGATCAGTTATCAGGCGTCCTAGCTTCTACGTCGCTCTGCTTTGATTTGTCGGTGTTTGAGTTATTTGCACCGTTGAGTGTTGGGGGAACCGCAATTCTGGCTGAAAATGCCTTGCATCTACCCACGCTAGCCGCAGCAGAGCAAGTGACGCTGATCAATACTGTGCCCTCTGCGATCGCTGCCTTGATCGAGATGAACGGCATTCCCAAGTCGGTGCAAACCGTCAATTTAGCAGGAGAACCGCTGCCGCACAAGTTAGTGCGCCAGTTGTATGAGCGATCGCACATCCAGCAGGTGTTTAACTTGTATGGACCCTCGGAAGACACAACGTATTCTACGTTTGCGCGAATTGATCCGCAGATCGAAGGGACACCTCCGATTGGTCGCCCGATCGCCAATACTCAAGTTTATGTTTTAGATCAGCAGTTGCAGCCTGTCCCCATCGGGGTTCCGGGTGAACTGTACCTGGGTGGAGCGGGGCTAGCACGCGGCTATCTCAATCGCCCCGATTTAACTGCCGAATGGTTTATTCCCAATCCGTTCTCAGCACCGGATTTTGCAGATCGGCTTTACAAAACCGGGGATCTAGTGCGCTACCTTCCCGATGGTCATCTCGAATTTCTCAACCGGATTGATCATCAAGTTAAAATTCGCGGCTTCCGCATTGAGCTAGGCGAGATTGAGGCGGCACTGAGCCAGCATCGGGCTGTTCAAGATGCAGTTGTATTGGCAAGAGAGGATGTTCCCGGAGAGAAACGCTTAGTCGCTTACATCGTCCCCCAATCTCTCGATCGCCATGCTTCTAGCCAAAACCTGGAAGACCAGCAGGTTTTGCAGTGGCAGATGGTATATAACGACGATCGCTTCCGTGACACTCAAACAGAATGGGAACCGACGTTCAACATCAGCGGTTGGATGAGCAGTTATACCAATCAACCCATTCCGGCAGAGGAAATGCGAGAGTGGGTCGATGCAACAGTTGATCGGATTCTCGCCTTACGCCCTCAGCGAGTTCTAGAAATTGGGTGTGGCACCGGTCTGCTGCTGTTCCGCATTGCACCCGATTGCACTGAATATTGGGGCACAGATTTTTCGCACATCGCCTTGAGTTATGTAAAACGAGTTTTGAGTCTGCCGCAATATCAACTGCCCCAGGTTCGGCTATTGCAGCAGCAGGCAGACCAGTTGGAAGGGATTGAGCCACACAGGTTTGATACAGTCATTCTCAACTCGGTCATCCAATACTTCCCTAGCATTGACTACCTTCTCCGCGTTCTGGAACATGCTGTCAATGCCGTTGCACCAGGAGGCACAATCTTTATCGGAGATGTGCGGAGTTTGCCATTACTAGAAGCATTCTACAAGTCTGTTGAACTCTACCAGGCTTCAGAGCTGCTCACGCCAGAGCAACTGCGCGATCGCATTCAACGCCGCCGACTTCAAGAACAGGAACTCGTGATCGATCCTGCCTTCTTCTCTGCCCTGCAACAGCACTTGCCGCAAATCGAGCATGTCCAGATTCAGCCTAAGCAGGGACGCTACGAGAACGAGCTAAATCAGTTCCGCTATGACGTGACCTTGCGGATTGGGGCAAACGTGGAAGCGCAAACCGGAAAAACTGAGGAGCGCTCCTGGCAGACCTATGCCAACAATCCTCTACAGCAACAAACGACCCGTGAATTTGTTGGTCAGTTGCGCGACTATTTGCACCAAAAACTGCCCGACTACATGGTGCCTTCTGCCTTTGTCTTGCTAGAGGCACTGCCACTGACCCCCAACGGTAAACTCGATCGTCGATCGCTGCCTGCTCCCGATCGACAGGAATCAACCGAGACTGCAACCGCCCCTCGCACCCCAATCGAAGAAATGTTGAGCGGCATCTGGGCACAGGTTCTGGGGGTGGCAACCGTGGGAATCAATGATAACTTCTTTGAGTTGGGTGGGCATTCACTGCTGGCAACTCAGGTCATTTCGCGTGTGCGAGAAGTCTTCCAGGTGGAGTTACCTCTGCGCTGCTTGTTCGAGGCTCCCACGATCGCGGCTTTAGCCCAGCAAGTGAAAGTAGCGATTCAGTCGCAGCAAGGCTTAGAAGCCCCTCCGTTATTACCCGTTCCGCGCGATCGAGATCTGCCGCTTTCCTTTGCTCAACAGCGATTGTGGTTTCTGCATCAGCTTGCGTCGGATAGCCCGCTTTACAATGACCCGGTTGCACTGCGGTTAGGTGGTTTGCTCAACGTCACAGCGTTAAAGCAAAGTATTAACGAAATTGTGCGACGACACGAAGTTCTGCGATCGCGCTTTGACACCGTCCAGGGGCAACCTGTGCAGATCATTACTCCTAGTTTGGATGTGCCGATCTCAATGGTTGATTTGGGAGATTTACCAGAGCCAGAGCGTGAAGCGGAAGCCCTGCGACTAGCAATTGAGGAAGCTGCCCGTCCCTTTGATCTAAGTGCCGATCCTCTGCTGCGGGTCACGTTACTGCGGTTGAGTGAAACCGATCATGTTGTCTTGCTAACCCTCCATCACATTGTTTCTGATGCATGGACAATGGGCGTTTTAGTACAGGAGTTATCAGCCCTCTATGCTGCTTTCTCGACCCATCAGCCTTCGCCCTTACCAGAGCTACCGATTCAGTATGCTGACTTTGCCCTATGGCAGCGGCAATGGTTACAGGGAGAAGTCCTACAGGCGCAGTTAAATTACTGGCGACAACAATTAGCAGCGTTACCCACCCTTGAACTCCCAACGGATAAACCACGTCCTCAAATCCAGAGCGATCGCGCAGCAACCCAAACCTTTGTTGTGCCCAAAGAAGTGAGTCGATCTCTGATCCAACTCAGTCAGCAGGAAGGTGTCACGTTGTTTATGACGCTGCTCACCGCCTTTAAAACACTACTTCACTGCTACACTGGACAAACGGATATCGGCGTAGGTTCCCCGATCGCGAACCGCAACCGAGCAGAGATCGAACATTTGATCGGCTTCTTTGTGAACACGCTGGTACTTCGCACCGATCTCTCCAACAATCCCACATTCCGTTCCTTGCTAGCACGAGTGCGAGAAACAACGCTCGGAGCTTATGCTCACCAGGATTTGCCATTTGAGAAGCTAGTCGAAGAACTGCGACCAGAGCGACAGCAGCAACATTCGCCGCTCTTCCGAGTTTGGTTTGTGCTACAAAATGCGCCGATGCCTCCGTTAGAACTACCAGGTCTTACCCTGACACCGTTCGATGTTGATAGTGGAACGACCAAGTTTGATTTAGCGCTGTTCTTCTTTGAAACCAGTGAGGGACTAGAAGGCTGTTTTGAGTACAACGCTGATCTATTCGATACATCGACGATCGCTCAAATGGTGCACCAGTTTGAAGCACTGCTCCAGACGGTTGTGGCGCAGCCGGATATCCAGTTGAGTGTTCTATCGAATCAGGTTGCCAAAGCTGCCAAAGAACAGCAGCTTCTCCAGGCACAAGCAATTTCCGCCACAAATTTACAACGACTTCAGCGCATCACCCGCAAACCGCTCAGTCGCGCTAAATCATGAGGAAGTAATGACACAACAAAACAGGGCAAAGCTAAGCCTAAACACATTGGGAACTACGAGCCGAAAATCTGTCAAGGTTTCGCAGTCCGCGTTAATTCAAACCAGCCATTTACTAGGAACCTCAATTCCGCTCGTGATTCAGCCAACGGTTGAGTCGATGGATCTGATTGCCTGGGCAACCTCGAATCGAGAGACGATCGAAGCGCTATTTCTTCAGCATCGTGCTTTGTTGTTTCGGGGTTTCAAGATCAAAAGTGCCGAGCAGTTTAATCAGTTTGTGCAAGCCACTGCTCAAGGAGAATTGTTGAGTTATCGCGATCGCTCCTCTCCCCGCCATGAAGTGGAAGGCAAGATCTACACCTCCACCGATTATCCGGCTCAAGAAAGAATCTTTCTGCACAACGAAGGAACTTACTGGTTAACCTATCCGCTCAAAATCTATTTCTGTTGTCTCACTGTTGCCGAACAAGGGGGCGAAACCCCGATCGCAGATACACAAAAAGTCTTGCAGCGTCTTGCACCCCAGATTCGCGATCGATTTACAGAAAAGAAAGTTCTGTATGTTCGCAACTATAACGATGGCTTTGGATTAACCTGGCAAACGGTCTTCCAAACCGACGACAAAGCTGTGGTAGAAGACTACTGCCGTCGCAATGCCATTGAGTTTGAGTGGAAACCAGGCGATCGACTCAGAACTCGTCAGGTGCGCGATGCGATCGCAAAACATCCGATCACAGGTGAACTAACCTGGTTCAATCACGCCGCGTTTTTCCATATTTCAACCCTAGAACCCACCATTCGCCATGCGTTGTTAACAGAATTCAAAGAAGAAGAGTTACCGCAGAACACCTATTACGGAGATGGTTCTGAGATCGAGCCGGAAGTCTTAGACGCGATTCGTGAAGCTTATCACCAGGAAACGATCATCTTTCCCTGGCAGGCTGGAGACATTTTGCTATTAAACAATATGCTCGTTGCCCACGGACGACGACCCTACAGCGGAGCCAGAAAAGTATTGGTGGGAATGGCAGAACCTTATTGCCACAGAGAATTCAACGTTGAGGAGTAGAAAGGTCAACATGCAGAGTGCAAGTATAGACAGACAGCAAGACACGATCGAGGGCTATTCCCTTTCTCCGCAGCAGAAACATCTGTGGAAGTTGCAGCAAAGGGATCAGCACCAACCTTATCGCGTCCAGGTTTCGGTGCAGATTGATGGAGCCTTCGATCGCGAGAGACTCAAATTGGCGTTGCAGAACGTAGTCGATCGTCACGAAATTCTCCGAACTACATTCAAATGCTTACCCGGACTTACGCTCCCGCTTCAAGTGATAGGTGAGTGCGATTTTTCTTGGTACAGCGAACTGAATTTGAGCGATCGTACTGCTCAAGTGCAAGTGAGCCAAATCGAAGCTCTCTTTCAAGAATTCGGTCAACTTCCGTTTGACTTCGAGCAAGGATCGCTGTTTCGGGTTGCTTTAGTGATGCTGTCGGCTCAGAAGCACATGCTGTTGATCTGTTTACCTGCCCTCTGCGGAGATGGCGTGGCAGTCAAAAACTTAATTCGTGAGATCAGTCAGGTCTATCGTGCCTGCACCCAGAATCAGGAATTAACCGATGAGCCGTTACAGTATGCCGATATTGCAGCATGGCAAAACGAATTGTTAGACGCTGAAGAAAGCGAAACGGCAAAACGCTATTGGCGCAAGCTAGCGATCGCAGAAGCACTCACAGTCAAGTTGCCCTATGAACGCTCGACTACTAAATCCTCTACTTTTCAGCCCCATGTTTTTAGTGCCACGATCGCTTCGCCATTAGTCGCCGAGATCAATGAATTTGCGAAAACATACGAGTGTTCTACAGAAACTTTCTTACTCACCTGCTGGCAAATTCTGCTGTGGCGCTTAACGGGGCAATCTGAGGTGGTGGTGAACACCGCCTTTAGCGGACGAAAGTACGAAGAACTAGAACCCGCGATCGGCACCTTCGTGAAATATTTGCCGCTATATGGGCAACTAAGCGATCGTGCTCAATTCATAAATGTGTTACGAAAAACCGAGGAGTTGCAGCGTGAAGCCGACACTTGGCAGGAATATTTTGCTTGGGAGGAAGAAGCGCGCGATCCATCCATCTTGCCCTTTGGCTTTGACTTTGAAACGCTGGATCTCACCAGTTGCGGTTCTGAGCTTTCCTGGTCAATTGATCGATTTTCTGTGTGTGTCGATCGCTGCAAACTCAGGCTTTCTTGTATCGATCGCCATGACGGTCTAACCACAGATTTTCATTATGATGCAACTGTCCTTCAAGCTGAGGACATCCAACGCTTGGCAGAACAGTTGCAGACGCTCCTCGAAAGCGTGATTTACAACCCGCAAGCAGAAATTTGTACCTTAAATATTTTGAGCGATCGTGAACGGCATCAACTGCTCGTAGCGTTCAATCACACGCAATTCGATTATCCAAATCAATGCTTTCATCATCTGTTTGAACAACAGGTTGATCATACTCCAAACAACATTGCAGTTGTCTGTGGTGACCAGCATCTGACCTATGCTGAACTCAATGCTCGTGCCAATCAATTAGCCCATTATCTGCGATCGCTCGGTGTCAAATCTGAAACGCTTGTCGGAATCTGTGTTGAACGCTCTCTAGACATGCTGGTTGGGATTCTCGGCATTTTAAAGGCAGGGGGAGCGTATGTGCCCTTTGACCCGGCTTATCCCCAAGCGCGCATCGCCTTTATGTTAGAAGACACCCAGGCTCCTGTCGTGCTGACCCAGGCGCGACTCCTTGATCGCTTGCCTGACACTTCAGCCCAACTCGTTTGTCTCGATTCCGCTTGGGAGACGATCGAACGATCGAGTGCAGAAAACCCGCCATCCTCGCTCACACCAGACCACCTGGCTTATGTGATCTATACTTCCGGCTCGACTGGAAAACCCAAAGGAACCTTAATTCCGCATCGAGGACTCGTCAATTACTTGTGCTGGTGTACGCAAGCGTATGGGGTTGAGCAGGGGGAGGGGGCATTAGTTCATTCGTCGATCGCGTTTGATGCCACGATTACGGGGCTATTTGCGCCCTTACTGGTCGGCTCGAAAGTCGAACTACTGCCCGAAGACTTGGGAATTGAAGCGTTAGCCATTGCGCTCCAAACAAAGTCGAACTATAGCTTGATCAAAATTACCCCTGCACAACTCGAACTACTGGCACAACAGCTTCCTGCTGAAACCGCGTCGCATCGAACCCAGATGTTCGTGATTGGCGGTGAAAATCTGACGGCACAGCACATTGCTTTCTGGCAAACTGCCGCTCCTGAAACGGCTTTGGTGAATGAGTATGGTCCAACAGAAACCGTAGTCGGCTGCTGTGTCTACTGGGTTCCTTCCGATCAACCCTCGACAGGTTCCATTCCAATCGGTCGCCCCATTGCCAACACTCAGCTTTATTTGCTCGATCGCAATCTTCAACCAGTTCCCACCGGGTTTCCCGGTGAGCTATACATCAGTGGCGCAGGAGTCGCGCGGGGCTATCTCAATCGTCCTGAACTCACAGCAGAACGCTTTATTCCTAACCCCTTCTGCTCAGGTTCTCGGTTGTATAAAACCGGTGACCTGGCTCAATTTCTTCCCAACGGCACGATCGAATATTTGGGGCGTATCGATCATCAAGTCAAAATTCGCGGCTTCCGCATTGAGCTAGGCGAAATTGAAACTGTTCTGGCTCAGCATCCAGCCGTGCAGCAAGCAGTTGTCATCGATCGCGAAGATACTCCTGGAGATCAACGCCTGGTTGCCTATCTCGTTCCTGCACCTTCTGCCACGCCCAACGCCTCCATTCTCCGACCGTTTCTTCAGGAAAAACTTCCTGCCTATATGGTGCCGTCTGCGTTTGTGGTGTTAAAGAAGCTGCCGCTCACCTCTAATGGCAAAGTCGATCGCAAAGCCTTACCCGCACCCGAACAAGTCAGACCCGAGCTAGAAGCTGCCTATATTGCGCCTCGCAATTCGATCGAATCAACCCTAGCCGCAATTTGGGCGGAAGTTTTGGGACTCGAACAAATCGGTGTGTATGACGACTTCTTTGACTTGGGCGGACATTCCCTCTTGCTCACGCAAGTCACCTCTCGCATTCACAATGCTTTGGGGATCGACTTACCCATGCGTCAACTGTTTGATGCCCCCACGATCGCTGCTTTAGCCGAGGTGATTGCTGACAAACAACTAGAGCAAGCAGACCATGACCTCCTGGCTCACCTGATAGCAGACTTAGAGCAATTGCCGGAAGCTGACGTTAAAGCTGCCCTGATTGCTGAAACATCTTCCACCGGGAGCATTGACCATGAGTGATCTAAGCCAACGCCTTGCTGCCCTCTCACCAGAAAAGCGGGCATTGCTGCTGCAACGACTGCATCAGACGAGCCAGCACCCAACCCCAACTCAGATTCAACGACAGGCACGATCGACGAACACGTTCCCGCTGTCTTTTGCCCAACAGCGCTTGTGGTTTCTCAATCAGCTAGAACCCGGTAACGCTTTCTACAATATGCCTGCGGCTATTCTGCTGAAGGGACACCTGAATATTGCAGCACTCGAACACAGTTTAGACGCACTAATTCAGCGTCATGAAGCCTTACGGACAAACTTTACCACCGTAGCAGGAGATCCTGTTCAGGTAATTGCAACCGCTCGATCGCACAATTTGTCGATCGTTGATCTGCATCACTGTTCAGAACCTGAACAAACCCAGAGAGTGCAACAACTCGCTCAAGCAGAAGCCCAACTTCCCTTTGATTTAGGGAACGATTCGCTCCTGCGGGTTTGCTTACTCCAACTGAGCGAGACGCAGCACGTCCTTCTGTTCACGCTGCATCACATCATTGCCGATGCCTGGTCATTGGGTGTGTTGATCCAAGAATTTGCCCAAGCCTACAGTGCTTTTTCGACAGGCGAGTCTCTTTCACTGCCAGAACTACCGATTCAGTATGCCGATTTTGCCGTGTGGCAACGGCAGTGGCTTCAAGGCGATGTCCTAGAGACTCAACTCCACTATTGGCAACAGCAACTCCAGCACGCCCCACCTCTGCTCGAACTGCCCACGGATCGTCCCCGTCCTCCGGTGCAGACTTTTCGGGGAGCCTATCAATCTCTCATACTACCCAACGCCTTGATGGAGGAACTGAAAGCCTTCAGCCGTCGTGAGGATACAACTCTCTTTATGACGATGCTGGCAGCCTTTAAGACCTTGCTGTATCGCTATACTGGGCAAACTGATCTTCTAGTGGGTTCCCCGATCGCGAACCGCAATCGCCTGGAAGTGGAGAATATCATTGGGGTGTTCATTAACACTTTGGTTCTTCGCACTGACGTTTCAGGCAATCCCACGTTTCGAGAGCTATTGGCTCAAGTTCGCAAAACCACACTCGACGCATACGCGCATCAAGACTTGCCATTTGAAAGACTGGTTGAGACACTGCACCTCGAACGCAACTTGAGCTATAACCCAGTCTTTCAGGTAATGTTCCAGCTTCAGAACGCACCGATGGCTGACCTGGAACTCCCCGGTTTAACGCTGAGTAACCTAGAAACTGCTGGAGAAACTACTCAGTTCGATCTGAGCCTCAACATGGCAGAAACCGAAGCAGGGTTGCAAGCCCTGATCGAGTACAGCACAGATTTATTTGATGATGAGACGATCGCTCGAATGTTAGGACACTTCCAAACCTTACTAGAAGGAATTGTCGCCCATGAGAACGATCGTCTCTCAAATTTACCTTTACTGACAAAGGCAGAACAGCACCAATTCCAGGAATGGAACCAGACTCAAGTTGAATTTGCCCAAGTCCCCATTCACCAGTTATTTGAGGCACAGGTCAAACGAACCCCGGACGCGATCGCTGCTGTATTCGAGCAGGAACACCTGACTTATCAAGCCCTGAACGATCGAGCCAACCAACTGGCAAGTCATTTGCAAACGTTAGGCGTTCGTCCCAATGGGTTAGTGGGAATTTGTGTCGATCGCTCCCTAGAAATGCTGGTCGGCATTCTCGCAATTCTCAAGGCAGGTGGGGCTTATCTCCCGATCGATCCGGCATATCCGCAAGACCGTATCGCCTTCATGCTAGAGGATGCAGACGTTGAGATTTTGCTGACTCAATCGCATCTCTCCCCTCCGCTTACCCAATCTAATCCAAAAGTTCTCTACCTCGATTCTGATTGGACAACGCTCTCCCCCGGTTCCCCGCTCCCCTGTTCTCCCGACCACCTCGCCTATGTGATCTACACCTCTGGCTCTACGGGCAAGCCCAAGGGAGTGCAAATCGAACACCATTCGCTGTCCAACTTTATCCAATCACTTCAGCAACACCTCAACCTCACCTCCCAAGATTTTTTCTTCTCGGTTACGACCATCACCTTTGACATTGCCGCGCTAGAACTCTTTCTGCCATTGACAGTGGGTGCCCGTGTCGTGATTGCCAGTCGCGCAGTCGCCTGTGATGGGGTGCGGTTATCTGAAGCGTTAGTCCAATCCGGCACCACGATCATGCAAGCAACGCCTGCGACTTGGCGGCTTCTACTGGCATCAGGATGGCAGGGTAACGCACAACTGAAAGTGCTTTGTGGTGGAGAGGCACTGCAAGCGGATCTGGCAAGTCAGTTACGGTCTAAGTGTGCTGCCCTCTGGAATCTGTATGGTCCTACCGAAACCACCATCTGGTCTACGATTCATGCGGTTGAATCTGACAACGAACCCGTTCCCATCGGATGCCCGATCGCCAATACCGAGATTTACGTGTTGGATCGCGATCGACAACTTGTTCCAGTCGGGGTCACGGGTGAACTCTACATCGGAGGTGCAGGGTTAGCCAGAGGCTATCTCAATCGTCCAGAATTAACCGCAGATCGGTTTCTCCAGCTTGAACTGCCAGAGCAGCAGCAAACACGACTCTATCGAACTGGAGATCTCGCCCGCTACCGCTCGGATGGCACGATCGAGTGTTTGGGACGCATCGACCATCAGGTAAAAGTTCGGGGCTTCCGCATCGAACTCGGTGAGATTGAATCCGTATTGTGTCAACATCCCACCGTACAGCAGGCAGCCGTTACCGTCAGAGAAACCGAATTCGGCGATCAACGCATCATTGCTTACGTTGTCCCTGTCTCCGCGTCTCATTCTGAATGGCGCAGCTTTCTCAACACAAAGCTCCCTGACTACATGGTGCCTGCTGCTTTTGTACGGCTAGAAGCATTACCTTTAACCCCAAACGGCAAAGTCGATCGCAAAGCACTTCCTGCACCGAGTGAGATTCCATCTGAGCTAGACCCAACACTTGAAGCCGCACAGACACCCGTTGAAGAAATGCTAGCTTCTCTGTGGTCGCAGATTCTCGGAGCCGAGATAGGCATTCACGATGACTTCTTCGCCTTTGGTGGACACTCCCTCTTAGCCACACAACTCATGTCACGCGTGCGGGATGTGTTCAATGTGGAGTTGCCGTTGCGTGTGCTGTTTGAAACTCCTACGATCGCGCGATTGGCACCGCAGATCGAGAAGGCAATGAAAACCAGACAACAGCTTGCCATTCCGCCTCTGCAACCCGTCGATCGTACTCAAGCATTGCCTCTATCCTTTGCCCAACAACGGCTGTGGTTTCTCAGTCAGCTTGCACCCGATAGCGCACTCTATAACTTTTCTGCTCACGTTCGCTTAGCCGGAACGCTCAATATATCTGCACTAGAGCAAAGTGTGAACGAAGTCGTGCGACGCCATGAAGCCCTGCGAACTGCCTTTGCTGTCGTAGAAGGACAACCCATCCAGATCATTGCTCCGACTTTGACCCTGCCCGTCCCGGTTGTAGACCTGCGATCTCTCTCCCCTGCCGAGCAGCAGACGGCTGTCCAACACCTAGTTGATGAGGAAGACCGTAAGCCCTTTGATCTAACCTGTTGTCCACTACTGCGGGTAACAGTGCTCCGGTTGAATGCAACAGAGCATGTCTTGCTATTGACCATGCACCACATCATTTCGGATGGTTGGTCTATGGGAGTGCTACTGCGTGAATTAATGGCATTGTACGAAGCGTTTTGTACAGGTCAGCCTTCTCCCCTGCCTGCGTTACCGATCCAATACGCTGACTTTGCTGTGTGGCAGCGACAATGGTTGCAGGGAGACGTGCTAGACCAGCAGCTTCACTACTGGAAACAGCAGCTTTTAGGGGGCAATTTGCCGCCGTTGAAGTTACCGACGAAGCCATCCCAACCTAAAAGCCAGAATTACCAGGGCAAAAGCCATACCAGTGAACTCTCGGTCGATCTCTCTAGACAGCTTCAATCCCTCAGTCGTCAAGAGAATGTCACTCTATTCATGACGCTGCTGGCAGCTTTGCAAACGTTGCTGCATCGCTACACCCATCAGGATGACATTGTGGTGGGCACCGACATTGCTAATCGCACCCATAGCGAAACAGAATCGCTCATCGGTTTCTTCGTCAATCTCTTGGTGCTGCGATCAGATATGCGCGGCAATCCTAGCTTTCGGGAACTGCTGCAACAAGTCCGGGAAGTCACACTCAACGCCTATGCTCATCAAGACCTACCTTTTGACAAACTGGTCGAAGAATTGCAACCAGAGCGCAACTTACATCAGACTCCGCTCTTTCAGGTGTTGTTCGTGTTGCAAAATACGCCCGTTCCGACGATCGAGCTAACGGATCTGACGCTGCATCCTCTCGACACCCAAGAGAACGACTTATCGAAATTTGATTTAGCCCTCTTTGTGACAGAGACGGAACCCGCCATTCAAATAGCCTGGAAGTTCAACGTCGATCGCTTTGACCCTGACACGATCGCTCAGATGGCAAATCACTTCACTGCTTTACTTGCCAGTATTGTCGCTGCACCCGAAGCACGACTTAGCACATTGAGTCTGCAAACCGCAGCCGAACCCAAACCACTTCATCAACCCCGCGATCGCAAAAACATGAGTTTCAGTAAATTTAAATCCATTCAACCAAAAGCCATTAGCGTACCCGAAACGGGACTCGTGACCACAAGCTATCTCCAGCCTGGAGAACCCCTACCCCTCGTTGTACAGCCTAATCTAGAAGATATCGATCTAATTGGTTGGGCAAAGAACAACCGGGGCTTGCTTGAAACGGAGTTATTAAAGCATGGTGCAATTCTCTTTCGCGGATTCAATGCGGCTTCAGTCCCAGAGTTTGAGCGGTTTGCCCAAACGATTTGCCCAGCGCTATTTGGGGAATACGGCGACTTGCCCCGCGAAGAGGTTAGCCAAAACGTCTACACCTCTACTCCCTATCCGGCTGATAAAGCCATTTTGTTCCACAACGAAAGTTCGCATCTGCACTGCTACCCAATGAAGATCTGGTTTTTCTGTGTGCAGCCTGCCCAATCGGGGGGTGAAACGCCGATCGTAGATTGCCGAAAAGTTTATCAACTGCTCGATCCCAAGTTACAAGAACACTTTGCCCAAAAGCAACTGATGTACGTGCGGAACTATACCGATGGACTCGATGTTAGTTGGAGCCGATTCTTCCACACCACGGATCGATCCGTTGTAGAATCTTACTGCCACAATCATGGCATCGAGTTTGAGTGGAAAGCTAACAATGGCTTGAGAACTCGCGAAATTCGTCCAGCAGTCGCAACGCATCCCAAAACTGGGGAAACGGTCTTCTTCAATCAAATTCAACTGCATCACTTGTCTTGTCTCGATCTCAGTGTCCAAGAGTCTCTGCTTTCCCTGTTTGGTGAGGAAAACTTGCCGCGTCAGGTCTACTATGGGGACGGAACACCAATTGAAGACTCAGTCGTTGAAGAAGTTTGTGAGGCGTATCGGCAAGCCACCGTTCAATTCCCTTGGCAGAAAGGTGACATCCTGATGCTAGATAACATGCTGAGCGCTCATGGGCGTAATCCTTATGGGGGTGCCCGCAAGATTGTGGTGGCAATGGGAGAACTCGTTAGTCCCGCAGAGACAGCAAGATTGGAGGCAGGCAATGCAGTTGCAAGATAGAGTGATTCAGGGATTTCGACTTTCTCCACAGCAAAAACGGCTTTGGGAAGTGCAACAAGAGAACGGCATCTATCGCGTTCAATGCACTGTGCGGATTGACGGTGATCTGAATTTAGGAGTGCTGAAATCTGCCCTTCAACAAATCATCGATCGCCACGAAATTCTGCGGACTGATTTTGTCCGTCCGGGTGGGCTAAAAACTCCCATTCAGGTCATTGCAGAAAGTGGTCAACTCGTATGGCACAAGATCGATTTGCGAGGCGGATCTGTCCAGCAACAACAGACCCACATCAATGCTTTATTTGAGCAAGATCGATGCCAAGCATTTGATGTGGAGCATGGATCAGGGCTGCGATCTACCTTGTTAACCCTGTCAGCCCAACAACATATTTTGTTGCTCAGTTTGCCTGCTTTGTGCGCTGATGCCAGAACACTGAAAAATCTCGTTCAAGAGGTGGGTCAGTCTTATCAGGCTTGCCTTCGGGGTGAAACACTTGATGACGAAATTGTGCAATATACGCAGTTCTCAGAATGGCAAAATCAATTCCTAGAAGATGAGGATGCCCACATCGGTCACACCTACTGGCAGCAACAAGACTTCTCAAGAATTACCACTCTAAAGTTGCCCTTTAAAGCAAAATCCATTCGTTCCGCTCCCTTTGATGTTCGCGCTTTGGAGCAGCAGATCGCACCGGAAACGATCGCTAAAATCAACGCACTCACCCAACAGCACAACACGACCCCAGCCACATTTTTTCTTGCTTGCTGGATGATTCTGCTCTGGCGCTTCACTCAACAAGGCGAGATCATCGTCGGTACTGCCTGTGAGGGTCGCAATGATGAGGAACTAGAAACTGCGATCGGTCTATTTGCCAAATATCTACCGCTGCGGTGCTGCCTGCAAGAACAGGAGACATTTGATCAACTGCTACGATCGATTGATCAAACAGTTCAGAATCATTTGCAATGGCAGGATTACTTTACTGGGAACCATTTAGAGCAACAATCTGAACGTGGATGGAAAGCACTTCCATTTTGTTTCGATTTTGATGATCAACCTGCGGTATACGCTGCTGACGGATTAGTGTTTACGCTTGAACGGCACTCTCCTTACACAGAACGCTTCAAGCTCAACCTCTCCTGCACTCAAACCGCAGAGGCTTTGTTCACCCGATTTCACTATGACGCGACTCTGTTTAGTGATGAAGACATTCAGCAATTAGGGGAACATTGGCAGGTGTTAATTGAGGGAATTGTTGCAAATCCCCAAAAAACGATCGCTCAACTCCCCATTCTCAGCGATCGACAGCGCCATCAACTGCTTGTTGAATTTAACAATACCCAAACTCCTGTCTCAAAGTTCTGCATGCATAAGCGATTTGAGGCACAAGTCGATCGCACTCCGAATCAGATTGCTGTCATCTTTGAAGACCAACAACTGACCTACGCCGAACTGAATACTCGCGCCGCTCAACTTGCTTGCGATTTACAAGCATTAGGAGTTAAGCCCGAAGTCCGGGTTGGAATTTGCTTGGAGCGATCGTGTGATTTCATCATTGCGATGCTTGCCGTTCTTAAAGCAGGAGGAGCCTATGTGCCCCTCGATCCTGCTTTTCCTCGCGAGCGCTTAGCCTTCATGATGCAAGATGCCCAGATCTCAGTGCTGCTGACTCAAACGCTTCTGCTCAAGTCAATTCCTGACATCACGGCTCCAGTGATCTGCTTAGACAATCGACCCGATTTCTCAGATTCGCCCCTACTCTCCCACCGTCCTACTCCCTCCAACTTGGCTTATGTGATCTATACCTCTGGTTCCACAGGTAAGCCCAAAGGCGTGGCAGTGGAACATCAGCAACTTTGCAATTATGTGCAGGGCATTCTGGAACGCTTGAACCTGCCCGAAGGATCTAGCTTTGCTACGGTGTCTACGATCGCGGCTGATTTGGGAAACACAGCAATTTTCTCGGCTCTTTGCACCGGGGGCTGTCTTCACATCATTTCTGCCGATCGCGCCACAACTCCGCAAGCTTTCGCAGACTATTGCCGCTACCATGCGATCGATTGCCTCAAAATCGTGCCCTCTCACCTGGAGGCGTTGCTCGCTAGTGGAAATGCTGATATTTTGCCTCGTCAACGGTTAATTTTGGGTGGGGAAGCTTGCAACTGGAGTTTAATTGAAACGATCCAGCAGCTAGCTCCTAACTGTGTCATTCTGAATCACTACGGACCCACAGAAACAACGATCGGTGTACTGACCTATCAAGTGGAAGACCTTCCTACTCATGCAAGAACGAACTCTGTTTTGCTGGGTCGCCCGATCGCGAACACACAGGCTTATGTCCTCGATCAACAGTTGCAGCCTGTCCCGATCGGCATTCCTGGTGAACTCTATATCAGTGGTGACAACCTAGCACGAGGTTATCTGAACCAGCCCCAATTAACCGCAGAACGCTTTATCCATCACCCATTTAGTCAGGACGGACGATTGTACAAAACAGGTGATTTAGTACGATACCGAACGGATGGAAACCTTGAGTTTTTAGGGCGAATGGATGATCAGGTTAAAATTCGAGGGTTTCGAGTTGAATTAGGCGAAATCGAGACAGCCTTATGCCAGCATCCCGATATTCAACAAGCGATCGTTCTACTTCGCTCCGATGTGGCAGGCAACCCGCGCCTAATTGCCTATGTCATTTCCCATTCTCAGGCAACCTCTACCACCCATGACTGGCGCAATTTCTTGAAAGCCCAAATGCCCGAATATATGCTGCCCTCAGCCTTTATTCGGTTAAAAACCCTTCCGCTCACGCCGAACGGTAAAATCGATAAGCAAGCCTTACCCATTCCCGATCTGTTCAAATCAGATCAGGAAACGACCTTTGTGCCACCCCGCGAAGCGTTAGAACTGCAACTCACCCAAATTTGGGAAGACCTGCTGAATGTGCGACCCATCAGTGTGACGGATAATTTCTTCGATCTAGGGGGACATTCACTTTTAGCAGTTCGGCTCATTGCTCAAATTGAAAAACAGTTCCAGCACAAATTGCCGTTGTCGAGCTTTCTTCAAGCTGCAACGATCGAGCATCTTGCAGGAATTCTCCGACAACAACCGCAAGCCTGGGAGCGATCGCCTCTGATTAAAATTCAATCGCACGGAACAAACTCGCCCTTGTTTTTCATGCACCCGATCGGAGGCAATGTGATTTGCTATGCCAGTCTGGCAAGCCATCTCGGTTCTGAGCAACCGTTTTATGGGGTTGAAGCGCCTGGTTTATATGGTGAGGAAGTTCCTCTAGAATCCGTTGAAGCGTTAGCAGCCCACTACATTCAAGCGTTAAAAACCATTCAACCTCAAGGACCGTACTATTTGGGGGGCTGGTCAATGGGCGGAATCGTGGCATTTGAAATGGCACAACAATTGCAACAACAAGGTGAAGCGATCGCGCTACTTGCCCTATTAGATAGCACCCCACCGCTCTCAAACACCCCATCTCCAACAGACAATACTAACTCTCTGGAAGATGCGAGACTGTTAGCTGATCTAGCAGAATCCACTGCACACTTTTTTGGTAAACAGTTGTCGATTTCACCCACTGAACTCCAATCGCTAGACCCTGAGCAGCAGTTGAATTATGTTTTAGAGGTGATGAAGGCTGCAAATTTTGTTCCTCCAGATATTCAGCCAAGTCAAATTCAGGCATTTCTTCAGGTGTATAAGAGCAATGCTCGCGCCCTAATGCGATACGTGCCGAAGCGTTATTCCGGTCAAATCACCCTCTTTCGATCCAGTCAGCCACTCCCAGAGCATCAAACCATTTCTGACACGATTTCCAGTTGGGCTTCGCTGTCAACTCAACCGATCGACATTCACACTGTTCCTGGAGACCATACCACGATGCTTGCTGAACCCAACGTTCAGGTTTTAGCAGCACAGATCAAAGATTGCTTGAAACGCACCGCCTAATTTGCACTAACCATTAAAGTGATGCACAGTAACTGGATCATCCGCTCAAAGCCCAATCCTCAAGCTCGACTGCGATTGTTCTGCTTTCCCTATGCCGGGGGTAGCGCGTCCATCTTCCGCTCGTGGTCGGATCAATTACCACAAAACATCGAAGTGTGTGCTGTCGAACTTCCAGGACGGGGCACACTGATGCGCTTAGCACCTTACACCCAGTTAAAACCATTAGTCGAAGCGATCGCACAATCGCTGTTACCCAATTTGAATCAACCTTTTGCGCTATTTGGTCATAGCATGGGCGCATTGATTAGCTTTGAACTGGCGCGTTTCCTGCGTCAAGCGTATGGATTAACTCCCCGTCATCTGTTTGTCTCTGGTCGTGCTGCTCCTTACATTCCCGATCGAGATCCACCCATCTATACCTTGCCTGACGCTGCCTTCATTCAGGAGCTACGTCGGCTGAACGGCACCCCTGAAGCGGTCTTGCAAAACCAGGAACTCATGCAACTGCTCACTCCGATTCTACGGGCAGATTTTGCCGCGATCGACACCTATCGCTATCAGCCTGAACCAGCCTTAGGGTGCCCGATCACAGCGCTCGGTGGCTTACAGGATTTAGAAGTGAGCCGAGACGATCTTGAGGCTTGGCAAACCCAAACGATCGCGCCCTTTCAGATCCAGTTATTTCTGGGGAATCACTTCTTTCTGCACTCGGCTCAATCGCTTCTATTAAAAGCGATCGCCCAACAATTACAAGCGGTTGAGCCAGCGATCGGTTAACAAAGACAACTCTTTATTCTCTAGTATTCATGCAATGAAGCATTTGCGATTGCCCAAACCACATTTTATCCGTCTAGATTCTATCTCTAGACGATTGAATCGCAACGCAGTTCGAGTGTTGCCATTACTGTTCGGTTTCATTCTGACCTTGATGTTGGGAACCTATAGTCTTGCGGCTGAACCCAAGGCGACCGAGATTCTCTGGGATACCATGGGGGTTCCTCATATCTTTGGTAAAGACGTGCCGAGTGCATTTCAAGCTTTTGGGTGGGCACAGATGCAAAGTCACGGGAACTTACTGCTGCGGCTGTATGGTCAGGCACGCGGACGATCCGCTGAGTACTGGGGCAAAGAATATCTCGAATCCGATCGCTGGGTACAAACCATGGGGATTCCCGATCGCGCTCGCCAATGGTATGAAGCCCAGAACCCCACCTTCCGTCGTGCGCTTGATGCCTTTGCGGCTGGTATCAATGCCTATGCGACTCAACACCCTGATTTGATTGGTGATGAGGTTGAGCGGGTGCTACCCATTCATGCCGTAGACGTAATAGCGCATAGTCAACGAGTTCTTCACTTTACATTTGTCGTTGATCCCCAAATGCTAGCTGGTTTGACCGACGAAGAAGTTCCAAGGGGATCAAACGCTTGGGCGATCGCACCTTCCCACTCTGAAAGTGGCAACGCTATGCTCCTTGCCAATCCTCATCTACCGTGGTCGGATCTATTTCTTTGGTACGAAGCCCAAATCACTGCTCCCGGAATTGATGCCTATGGAGCAACACTCGTCGGGATTCCTGTTTTAGCGATCGCATTTAATGATCACTTAGGCTGGACACACACGGTGAACACCCACGACGGTTGGGATACCTACGAACTGACATTAAGTCATGGAGGCTATCGGTTCGATGATAAAGTCCGTCCTTTTGAACGAGAAGAAAAAACTCTGAAAGTTAAGCAGTCAGACGGCAAATTGCGTAAAGAAAAACTGATGGTGCGGAGATCGATTCATGGCCCAGTCATCAAAGAAGAGAAGGGTAAAGCGATCGCACTGAGAGTCGTTGGACTTGATCAACCTGGCTTGCTAGAGCAGTGGTGGAACATGGCACGAGCCACCAACCTATCTCAATTTGAAACTGCTCTACGCCCATTACAACTCCCCATGTTCACCGTGATCTACGCCGATCGCGAGGGACATATCATGCACCTGTTCAATGGACAAGTTCCGGTGCGAAAACAGGGAGACTTCGCCTATTGGGAAGGCATCATTCCTGGGGATACATCTGCGACATTGTGGACAAACTATCATCGCTATGATCAATTACCACGTGTTCTAGATCCTGCTAGCGGTTGGCTGCAAAATGCTAACGATCCACCCTGGACAACGACCTTTCCTCGTGCGATCGATGCCAATGACTATCCCTCTTACATGGCTCCCCGTGGACCCATGAATTTTCGTGCCCAAAGTTCCGCTCGAATGCTCACTGAAGATAGCCGCATCTCATTTGAAGAGATGATTCAGTACAAACATTCAACTCATATGGAGCTTGCCGATCGTGTGCTAGATGACTTACTGCGTGCAGCCACAAATGATAGTAGCGAAATTGTGCGTCAAGCCATTCCAATTCTGAAAGCGTGGGATCGTAATGCCAATGCAGAGAGTCGGGGTGCGGTTCTCTTTGCCGCTTGGGTGGAAGCGATGAACCTTTCCAAAGCATTTGCAACACCCTGGAACGAAAACGCTCCTCGCACAACACCCAATGGATTGAGCAATCCAAAAAGCGCAGTTGCCGCCTTAAAAACCGCAGCTACTAAAGTGAAAACAGCGTATGGAGCACTAGATGTGCCTTGGGGAGACGTGTTCCGCTTACGTTATGGCTCGATCGATTTACCTGCTAATGGAGGTCCCGGAAAGCTCGGAATTTTCCGGGTGCTCAACTTTGTTCCGAACGACCAAGGGCAATTTGAATCGAGCGATGGTGATACCTTTACTGCTGCGATCGAATTTTCTAACCCAGTTCGGGCGATGGCACTCACAAGCTATGGCAATGCAACTCAACCCCATTCTGCTCATGTTGGCGATCAATTGAAAGCGTTCTCCCAAAAGCAACTCCGCCCAGTCTGGCGATCGCGTCAGGAAATTTTGGCTCATCTAGCTGAGCGACAAACATTTTGAAGAAATACCGCTCCCGGCTCAAATTGCTTCACTAATCATCACGTCTAGCAAATCTTGACCCTTGCAATTTGAGTCAGATTGTTTCTGAAGTTGAGCCTTTAGTCTTTGACAGTCATGCAAGCTTTCTGATAAATTCTTGATTGACTTATTTGAAAAATATTCTTAATAAGTCCCTAAAATGTGTTCGAGGGAAAAATGATGAGTGCAAAGGCTTGGTTGTGGGCAGTTGTCCCTTTTTTAGCATTATTACAAGGGGTGAAACCGGCAGATGCTCAGGTTTCGAGGCTCCCTGAAATCGAGTCTATATCAACCGCAGCAGGCACTGTAGTAGCACAGGCTCCGCCAACCGTGGAACGGGTTAATATTACTGATGTCCAAGTGAGATCGACAGAGAATGGTTTAGCCCTACAACTCACTACAGCGCCCAATGCAGCTTTGAAGCCTATCATTCAAACATCGGGGAATCGTTGGATTGCAACCTTTGAAAATGCAGCGCTGGCATTACCAAGTGGGCAATCATTTCAAGCAAACAATCCAACGGCTGAAATCTCGCAAGTACAAGTTCAACAAGTCAGTAATATACAAGTACAAGTAGAAATTATTAGCAAAAGCGAACTTCCTAATGTCGAGATCGCTCCCACTGCTGCCGGGCTGTCGCTCACGGTATTGGCGAATGGGAAAACATCATCCGATACAGCAACACGGTCTGATGCGGAATCAGAAGAAGAAGAAGTCGTCGTGACGGCAACCCGTACTGAGGAACCGTTAAAGAAAGTGCCGCGATCGATTACCATCATCAACCGCCAGCAGATTGAAGAACAATCACGCCTCACGCGAAATTTGGGAGATATTCTCGCGAATACAGTGCCAGGATTTAGCGCTCCAACTCAACGCACCAATACCTTTGGCTCAACTTTGCGAGGACGAGGCATTTCGGTCTTGATCGATGGCGTTCCTCAAAATGGAAACCTACAGTCTTTGCCCACGCAATTGACCTCGATCGATCCGAGTGCGATCGAGCGCATTGAAATCGTTCGGGGGCCAAATTCGATCTACGGAGGGCAAGCAACGGGCGGTACCATCAACATCATCACCCGCAAACCATCAAATCAATTGACCTCTACTCTTGAACTTGGAACCACCACTGCATTAACAGGCTCAGAGGACAAATTTGGGTATAACCTGCAATATCAGTTATCTGCCAAGCAAGGAGCGGTCGATCTAACTACTGGGATAGGGTTAACCACAACAGGCACATTTTATGACGCGGAAGGGGATCGAATTGCCAATAGCGTGAGTCCTGACGATACTCAGATTCTGAATGGCTTGTTGAAAGTTGGCGTAGATCTCGATCCACAACAGCGATTGCAATTTACTGCAACTCACTACAACAATCGTAGAAATAACAATTTAACAGAAGATGCAAGCATCGATGTGATACCTGGAATTCAAAAAGCACGCACATTAGCGATCGATGGGTTGCAAATTTTAGGCACAACTGAAGGCTCATATATTCGCAATACGAATGTAGCGCTCGACTATACGCACCAGAATCTTTTTGGCAGTAAAGTACAGGGGCAGGTTTACTATCGCAACAATGCGTTTCGTGGTAGTGGGATTCCCTTTGATGGTCGAGACTTTCTAGGCGTGATTGGACGAACACCCGGTGAATCCGAGCAATTCGGGACACGGCTCCAGGTCAACACACCCTTTAACCCAGACAAAACCTTACAACTCCTATGGGGAGTTGATTACAACAACGAAAAAAGTTTCCAAAACATTGAGGTTTTTGATCCAGAAGCCTTTGATGCCAGTGGTGGCAGTGTGTTTCGTAAAATTGCAGAACGAACCTTCGTTCCTCGTTATACCGTGAATGACCTGGGCTTATTTGCCCAGTTACAGTGGGATGCCAACGATCGACTCAATCTCAGTGGGGGATTACGCTACGTCAATCTTGGCTTAAAGATCGATGATTACGTCACCATTAATGATCAAGCTGTTCAAGGGGGCGATCGTCAGTTTGACACAGTAGCCTTCAATGCAGGTGCAACCTATCAACTCTCTGATCAATTGAGTGCCTTTGCGAGCTTTTCACAAGGATTTTCCGTTCCAAGCTTTGGATTTATTTTGCGAGAACCTCCAAGTGGGTTCACGCGAGTCACCGATGCAATACGGCTAACAGAACCTCAGAAAGTCAACAACTATGAAGTGGGTCTACGAGGTCGATGGTCAACTGTCCAGGCTAGTATTTCTGGGTTCTACAACACTTCAGATCTAGGGGAAGATTTTCGCTTGGTCAACAATAATCTAGAGATTGTTCGTGCACCTCAGAGAACCTATGGGGTTGAAGCGACCTTAGATTGGCAAGCAACAAAAACACTATCTTTCGGTGGAACACTGACCTGGCAAGAAGGAGAAAATGATGAGGACGAGGATGGAAATTTTCTTGCATTAAATAGCATCACCGTTCCTCCTGTAAAACTGACTGCCTATGTAGAAAATGAAACCCTTCCAGGTTGGCGAAATCGATTGCAACTGCTTTATTCGGGTAATCGCGATCGCGCGTTCCAAGATGGAGTAGATGGTGGCAAAATTAGTAGCTATGTCACGCTGGACTTTATCAGTCGCATTCAACTAGGTCAAGGTGAATTACAGATTGGGATTCAGAATCTCTTGAATACTCAATATTTCCCAGTCTATTCGCAGTACTTTGCACCCTTCTTTGACAGTGCAAATTATGCCGGACAAGGTCGCACCCTAAGCGTGACCTACCGCGTCACATTCTAATAGAACTTTCTGCTATAGCACTTCAATCAATAGTCCGGGCAGTATCGCTGCCTGCCTGCCCGGACTATTGATATACCAGAATTCAAGCATAACCCTTTTCCCAAACTCAGCAATGATAGTTGAATATACCTTTAGCATCAGTATGGAGGGGTCATGAGGAGGGTAGCTGACCACTTGCTCTCAGGATGGCAACTTGAGCGGCATAAATCTCTTTCTTATTTGTATAGCGCTTGAAACTTCTGCGATCGCGGTGTCGAGTCAATTTCATCGCTTCCCCTTCACCCAAGCCATACTTGATTAGCAAATTCGTCGCATAGGTATGCCGCCCCCGGTGCGAGTGCAAATCAATGCCCGTCTGTGTCTCAATCCATCGCATGACTTCCCGAATTCCCCAATAGGTCAATCGCTGTTTCTGACTCTTTGTTCGATTCGAGTGTGCTGCGTATTTTCACAACTTCGGGTTCTCCGCAGGTTTTGGTGAGCTAGATTAAATATGTGAAAATTCAGCATTCATTTCATTGTTCAAGTAGCCAATCTCAGTTCTCTAACCGAAAATGGATTTCTATCTTTCCTGAACCATTGCGTGTAGACAAACAAATTTGTCGTCCTACTATTCTATAAAGTAAGACGATTTCAATGCGTATTAAGATTTGCTTTACTGTTTGATAGCTCTAGCTCGTCAAGATAAATCTCCGATTGAGTAAATCAAAACTTGCCCTGCCATACATCTGCCGCTTTAGTAGTTTCAATCGGTTGATGTTCCCTTCCACAGGTCCATTGCTGATATCAGTCATGAGGCTCGCTTTTACGGCAGCATAGTCCTCTTTTAACCCTTGAGCAAATCCCTGAAACAGCTTCATTGAACTACTCATCGCTTGATCTAACCAGATATCCAATTGCTGAGGTAATCGTTCTCGCACCAGCTTTGTAAACCCTTGCGTCAAATCAATCGCTGCTGCCAATTCGGGATGTTGTGTTTTGAGGTCTGCGATCAAAACTTGCTCTACATCCGTTCGCTGATCCGCTCGACGCATCACCATCCAAGTCGCTCGACGAGCAGTCAACGGGGGGTGTTGTAGATCGCTAATTGGAAGCTGGAGTTGCACACCGAGTTGAGCACGGTGTTGCTTTTGTGTCTGCCGCAATCGATGAGTGTATCGAGCGACCGTTTGATAGCTCCCTCGATACCCTTGCTGTTGGATTTCTTCAAACAACTGTTTCGTATTGCTTTGTCCTTGATTCCATTGGTTCAGCACATAGGGTTTGTAGGCATCGAGTTGACTACGTTGAGAACGACCTCGATGTGGATGTGGTTGCCATTCAGGAAACTTGGAATGGCTCAAGTAGCGATACACCGTGCGTTTTCCCATGCCGAGATGTCGGGCGATCTCCAGGATCTCCCAGCCTTGCTGTCGTAACTGATGCACTTGCTCGTACTTTGCAAATCGGCGTTCTCGCGCCTTGGCAGAGCGCTCCTGTATAGCTAGACGAGGTACTACGGGAGCAATCATGATGGCATCGTTCACAGGAATTTGTGCGGCTTCCACAGCTTTCAATTGCTGGGTGTGCATTGCTAAGATTCGCTCTAGTACTTCTGCTAAATTTTTCAACAAATGGAAGCGATCTGCAACCTGAGTTGCATTCGGTGCGCCTCTCGTCATGCCTTGTCGATAGGTCTTTGATCGATCACGGGAGAGAACTTCCACGCCTGGATGCTCTTTTAACCATTCTGCTAAGGTGTCTGCTTCGCGATCTGGAAGCAGCACAATCGGTCGATTTGTCTCTAAGTCAACCAAAATTGTGCCGTAACGTTGTCCACGCCGGAATGCAAAATCATCTACTCCTAACGCTTTGGGCGTTTTCACCGCAGGTATCGACTGGCGAGAGATCAGCGATAGCAGAGTGTTTTGACTGACCTCACAGTGCAGTGTTTTGCTCAGTTTAGCCCCACCTTCACCGCCTGTATACAATGCGATCTCACTCAGTTGTGCTGCTAATCGCTTCGTTCGTCTTGCCCACGGAGCCATCACGCCCGCGATCCGTTCCGTGAAGATTTTGCGATCGCATCTTTCCTGATCACAGAAAAACTTGCCCACGGTCAGTTGGATTACGATTTGGTAATCTGCCCACGGTAAATCTGCCAATGTTCGTTCGTAGAGACTATGCACTCGATGAGCAACCTGATCACAAACGGGACAACGAACAATCTGCTGTACCGATTCCATCAAAACTCGAATCTGCCTCTGTTCTACATCAAGTTCGTAATTCTGTAATTGCAGGTGTTCTGGGTTAGGAAGCAATTGGGTTAAGAGTTCCACTATCTTTCCGATGCGATTCATCACCATTCTGACAAATCTTCACCAAAACCTGCGGTGAACCGAACTTCGGCAGGTCATTCTCACTCAACTTCGGCAGGTCTAGAGATAGCGTAACTGAACCAAGTCAAGATAGCAAATGTTTTTTACTAGGCAATCAGTTTGAGAAACAGTTACGCAAATATGAGATGTCTGCTAAAAGCAACACAGACATCAACTGAAAAAGGAATGATAGCAAAATTACTCTGCGTCAATGCTATCGGAATTGACATTGACTTTACTGGTGAGTTTTCGCATCGACTCGCCTTTGAGAACTAATCGGATGGAATCATGCACAATGCGGTCAAGCATGGCATCCGCCAAAGTTGGGTCTTGAATTTGCGAATGCCATTGATTGACCGGCAGTTGAGTGGCAAACAAACACGAAGCTGTGCGGTAACGAACATCGAGTAAGTCCAATAGATCGCGAGCTTGGTCAGACGACACGGCATCTCTCAACCAATCATCTAGAATGATCAATTCAAACGCCGCGATCTGTTGCTGAAATCGACGAAATGAGCCATCAGCTTTGGCAAATTTGAGTTCCATCAGCAAATCTGCACACTTGAAGTAGCGCACGGAATGTCCCAAAGTACAGAACTGATCTGCCAGTACCGACGAGAGAAAGGTTTTGCCCACTCCCGTCGCTCCGACAATAATCAGATTGAGATGGTCTTGCACCCATTTACCACCTGCTAGCTCCAAGAATTTCGTCTTCGACAACCCGCGTGGAACCGTAAAATCAATATCACTGAGATGAGCCGTCGTTGAGAGTTGAGCTTGCCTTAATCGGCGTTGGAGGCGCATCTGTGAACGATGCAGTTGTTCACGTTCCAGCAGCAATGTGAATCGGTCTTCAAAACTCAAATCATGATAGGTCGGACTGTTGCGTTGCTCCATCCAAGCATCGAGCATTCCCACCAGTCGCATCGCTTTCAATTGTTCGGTAACAGAAGAGGTCATAGGTCTAGGTTGAGATTAATGATAGTACTGAGCGCCGCGCAGGTTGGGGTGTTCAATCGCAGAAGTCGCAACGGGTTCAGCTTCAACGGTTGCCGTATCAAGGCGCGTGGCTAAAATCGAGCGTAATCGTCGCAAACCCACCATGCCAAAGGCATTCGCTCGCCGACAAGCCGCTTCGAGTCGTTGGGTTCCATGAGTGGTTGCCAGTCGTTGAATGCCTCGAATTGACCGAAAGGCTTGTTCTTCATGCGCTTTGGTGTTGAAGATTGCTTCAACTTGAGCACGAGTGTGACTGCCAATCTGGTCTGCCCAAGCGAGAAAGCGCTCTTTCGATTGACGCTTATATTCCCAATGTTCTGGGGGCATATGCTCAGCGACGGTAGAATGTCGATACTGCACTCGTGAGCGTTCATGCACCGCAATGCGCTGATGGTCGTGAAAGACTTCAATCAAATGCTCAGCGATCTTCACTTGGACTTCGCGTTGCACATACCAGTAAGGTACGGAATAGTAGTGCTTTTCCACTTCCAGGTGATAATCCAAATTCACCTTTGCCGTTCTCCAGCGTGCAAACGTAAAGGGGTGACTGGGCAAGGCTTTGAGGGCTGGCTTGTCTACCTGCTCAAATAACACCTGACGGGAGACTCCATACCCGCTCATGACGCGATCATTTAAATGCTGCAAGGGCACCAGAATCGCTGCGTTCAAGTCAGTAAAATTGGTAAATCGCTCGTGTCGTAAGGGGGCAAGGATTTGTCGCTCGACTTCTTGCACCGCTTTTTCGACTTTCGCTTTGTCTTTTGGTTTGTTGGGACGAGCGGGTAAGATGACCACATTGAAGTGTCGAGCGAACTCTTCGTAACTGCGGTTGATCCCTGGTTCATAGCGACACGGGTCGGTCACCCCGGATTTGAGATTGTCCGGTACAATGCATTCGGGCACACCCCCAAAAAACGGCAAGGCGCGTTGATGCGCGCCAATCCAATGCGGTAATTCTTGACTCGGTGTGGCTTCTGCATAGGTGTAGTTGGAAGCCCCAAAACATGCCACAAAGATTTGTGCTTGGGTGACGGTCTGAGTCTCTGGATGCATCACTTCAACCGTTGGTCCGCAATAGTCTACGAATAGCTTCTCACCTGCCTTGTAGACCTGTCGCATCGTCAGTTGGTGACGCACTTTCCACTTGTTGTAGCGACGACAAAAGGTTCCATAGCTACAGTCCCATTGCTGCTTATCGATACCCTCCTGCCACAATAATGCCAAGGTTACACCTTTACGTTGCAGTTCTATCTCTAGTGTCGTAAAATCGATTGTCTCTAGTTTCTCTTTAACTGCTCTTTTTCCTTTTCCTAATTGTGCCTTCGCTTCACTGTCACTCAGTTGTTGAATCTGTTCATAACTCAATCCTTTTGCAGTCGCTCGACGAATGTAATCTTGTACCGTTGACCGTGCAACCGCACAACTTTGTGCAATCGAGCATTGGCTGTGTCCTAACTCATGCAACCGCATAATTTCTCGAAATTTGTCCATCGACAGTCCCGCTCCTTGTCCGGTTCGTTTGCTCACGTCTTCTACACCCTTCAGTCAATTGCGACCGCAGTGTAGAGCCATGTGCCGAAGTTGGCTGAGAATGACCTGCCGAAGTTGAGTGAGAATCGGGTGCCGAAGTTACATGAGAATCACCTGCCGAAGTTCATGCAATTTTGCATGTGCCCACGAGATACGCAACCAGTGCATTAGGAAGACTCAGAACGCTTGTCAGATAGGCAGTTGAGGAACTCAATCAACTTTGGCGACACGCCAAAAATCTCAACAGAAATCTGGAGTGTATTGGATCGGGCTGCATTTCGTTTCAAACGTTCTGCCCAAGCGAGTCGTCGATGAGCACGTTGGCTGCGAGTCAGGTAAGAGATCGCGGGTTCGATAGTTTGAATTGCTGAATTGCTCTGTTCAATCCGAGATTGGTGTCGCCGCAGGTGTTGCCGAATCTCTCGCCGCAGTTGAGTCGCTGGAATGTCTGTCCAGATCAACGCTTGAGTCCCCTGTACGGTTTTCATCGGAGCTTGAGCAATGATCGTAATCTCAGGCTCTACGGCAACTGTCGGAACCGGAGGCAGCTTTGTTCGGATGACTGAAATTCGTCTGCCATTGGTGTTTTTGGAATCATCGGACAGACAATGTTGCTTTACGGGACAGCTCGCACAAATGCGCGGATTCATACTAAACAGCATTTGCATATCGCCGCGGCGAGTATAGCGAATTTCACGGCGGGACATACGATGACCTGCGGGACATTGCACAGATTCATCATCCATGATTTTGAAGTCTTTGCCTGCATACTTATGACGACTTTTCGCCCAGCCCTCCGCAACCGTCATTGCACCATAGCGAGGGGTAGGGTGACTCGATTGAGGCACAGCTGCAGGTTGAGGGGCTTCGGGTTGAGGAGTCGCAACCTCCTCCGTCATCTCTGGTAAAGCAGACGACCATTCTGTTTGCCGCTCACACAACTGAGGCGTATGCCGCGTCAATTACTTTTGGGCTTCGCGTCAATTAGAACAAATGCTCAAACCTTTACAGATGCAGAGCGATCGCATCTCAGTATAATTGACGCGAACCCGATTTGTAATTGACGCGGCATAATTGGCATTCCCACTGACATCGCCGTTTCAGTTGCTGAACGATTAGCACAACTGGCACCGGGTGCAAAGGTGGTAGAAGCGTTTAACATTACATTTGCCGAGATTCTCGCTTCTGATTCTCGTCAATTTGGAAGTGAACATCCAACCGTTTTTTACTGTGGAGACGATGCCGAAGAAGGCGATCGCGGCTCAACTCATTCAGGACTGTGGCTATGATGCGATCGATGCTGGCGGGTTAATGGTGTCGCGCAGTCTGGAAACCTTAGCCACTGCCTGGGTACAGTTTGCAGTGGTCAGTAACCTGTTCCCAAATGTTGGTCTTAAAGCGTTGCGTCGGTAGGTTCAGTATACGTTCCCCTTTCCCCTCAACCCATGCCCCTCAAACCAAGCTCCCTTCTTGTCAAAGCAACACTGCTTTTGAGTAGTAGTCTCACCGGGCATTGTCAACTTAACCGATGATAATCAAAATTAGACACAATAATTTCTAGATCGCGGTCATCGCTCCAGTTTACGCAGCATCTTTCACGCAGGTGATTTCCCACGAATCCTCAAAGCATTGGCGCATCTGTTCTCGATATCGTTTTGAACTCAGGTCATGTTGCTTCGGGTGAAAGTGGGATCGAATCGGGTCAAAGGCTGAGAGAAATCGTTGCGCTTGCCCTGGAGACTTGAAGCGGCGCATTCGTCGTTCTCGTACCCTGGTCGGTTGATGCGAATTTTCTGCCCGATTATTCAACCCTTTGTGTTGTCGATGTTCTACGCTCGGCATCACCTGTTTCTTTGCCGCTTCATAACTCTTCAGCTTGTCGGTGACCATCACCCGTGGCACAAACCCTTGTTTCTTCAAAAGCTTGCGGAAAAATCGCTTCGCTGCTTCAGTGTCTCGATGGCGTTGCAGTAAGACATTCAGCACGTTCCCTTCACTGTCTACTGCCCGCCACAGGTAGTATTGCTGCTTCTTGATTGTTACTACCATTTCGTCAAGATGCCATTTGTCTGTGATGTAACGACGCTTGCGCTGCAACTGATTCGCGTATTGCTGTCCGAATTTCTGACACCATTCCCGAATCGATTCGTACGTCACCTCAATGCCTCGGTACAACATCATCTTCTCGGTGTCTCGGTAGCTGAGGGGGAAGGTGTAATACCACCACACACAGTAACTGATGATTTCGCCGGGGAAGCGATGACGGGAGTACATGGGCAAGCGGATGCGCTCAACGTTGAACCAGTACGATCATTCTATAGCCCGGTTAACCTGACTGCGAAGATAAAAGAGTCTTTCTGCTGCCGTCTTTTCCACAGTGTCATAATCACTACCTCATTCCACTCTGTAGTCTAGCCTGCTGAGAAGAAAAATTCGGATGAAGAATTGCAGTCTTTTAAGATCCTCTTGATGGAAGAGCTTGGTTTCCATGCAATCTAATCCTGCGAAGTTAGAACGAGTCAACTTTCTCTATACTATGCAGGAACGAGCTTAGGACACCTAAGCATTCCTGATTGATAGGTATTTCTACAGCTTCTGACCTTCTGTACTGCAACGTTGCGGTACAGAAGATTCTTGATATTTCTAGGCTCAAGTTTGAGAGTCATGCAAAATCTTCAGCGTATTGCAGGTCTTGAAGTGTTTGGAATGACAGACCTAGCGATCGCGCAACGATCTCTAATGCAACTCCTTCTCTCAGCAGATTCCTGGCGATTTTTAACTTTTCTGCCTGTGCTTGATCCTCAGTTTTGAGTGGAGCGAAGGGAAGAGCATTATTCAATCCAGCACTTCCTAAGCTTTGCTGACGTTTTTGACAATTTCTAAAGAAAGCATTAATTGCAGCTTCTTGTTCAGCCCGAAGGGTATAACGACGAAATACAGACTCGCTCTCAATTCCACCTAATCGACGGGCATGAGTGGGATCAATATCATCCAGCAGCAATTCTGTCAGATAGGTGTGTCGAAATAGGTGAGGATGCAGATTTTGGATTTCAGCTAATTCTCCAATCTTTTCAATTGCAAAGTAAATTCCATGATACGTTAGTCGCTCCCCGCGCCGGGTCACATGATGTGAGAGTAGCAGTGGACGATCACAGCTTAGTTCCTCTCCCTGACTTCTACGCCAATTCAGATAAGAGTCAATCTCAACCCAAGAAGCGGGGTCAAGTGGAACGATTCGGGGGCGATCGGTCTTAGTATCTGCAATGAAAAGAACTTTTCCGCTGAATCCGTCTGTCGTGTGATTTCCGATCGCGCCCAGATTCAAGTCAACCACTTCACCTGCTCGTAAGCCATGACTAAGAATATGGATGAGTGCGCGATCTCGCAACTGCGTCTCTCCGCGTTGGTCAACGGCACTCCAAACCAATGCTTGTTCTTCCTCAGTTAAGCTCTGCGCTTCCGGCAGAGGAATTGCTTTTCCTTTGAGTCCGATCGCTGGATTTGTGGGTACTAAATCAGGATAGGTCTTGTGCAGCCAAGCAAAAAAGCTCCTCAGTGCCATCACCGCTAGGTTGCGACTGCTTGTGGAAAGTGGTTTCCCCTGGCTGGTTCGCACTTCCTCCGTCAAGTAACGCAAATAATGAGCATTGAGATGATGCGGTTTGATTTCGCTCCACAACAATTCTGACCACAACAAAAAGCGGTAAAGCTCTCGTTCGTAGTTTCTGCGAGTATTTGGCTCAAACCCTCCCGCATTGAGAAACTCCCGCACTTTCACACTACGAATATCTGTTGGTGGCAACCGTAGTGTCGCCACCTTACCTTTTTGTCTCGGAGGCGAGGTGCGATCGTCGAGAGGCAAGGGGATCAAATGCGCTTCAACTTGTGGGAGCGATCGAGCAACCATACTTTCAATCCATTATTAAAAAATCAGCGTTGAGTGTGTCCAACAATCCAGATTTCCCCGTCGTACCAATCCCCTCGTAACTCCAACAAAAATCCTCCTAATAATAATGCCAACCAAACTTCGATCCACGGTTGATTTAGCTGCTGACACAACTCGACAAAGGGAATCGCATGAACCTGAGCCGTTTCCCAGAAGGTAACGATCGCCTCCGTCCACTGAGCCACATCTTCATCATGAGCAGTCTCCATTGCGGCTTTAAATGCTGCGGCTGCTTCTGCATCCGTTAACTTTGCGTCTTGCCGCAACTGCTCACCCATGACCGTGATTAATTGAGCAGAATTAACAGGTCCAGCCGCAGATTCAGTTGGCTCTATTTTAATTGGAGATTTCCGATATTCTGGATAGGGCGCGGGGAGATCATATTCAACCAACCTAGATAAATTAAACTCTTGCGTCTGCATCACTAAATCAACCCGACCGGAAATATCGACAATTGGCTCAACTGGATCATGCTGCTGCTTCCAATCTTCAATCAAGACATCCGAGCGTAGACAAATTAATTCTGCAATTTGTTGCAAAATTTCACCTGCTAACTCTAGCTGCACAGAAGCCGATTGAGATGCGATGATTTCAACCCATTGGTCGTAGGTTTGCCATACGCTCGTCAGTACCTCTTTCTCATCAGGAAACGCAGTCGCTACTTCTAGCGATCGCCGTAAATCGAGTTCGAGTTGCTGACTATCCATCGACTCTCACCTAATAATCAGTTCATCGCATCGGGCGACCCGTACAAAGCGGACAGAGCGCAGGGTGACGTTCATCTCCCTCATCATGCAATCGACCAATGCGATATGTCTGATATTCCGGAAAATTTTCATTTAAGACTTGGTTGAGTGCCCTTACCATACTTGGAATGAGATAATCTGTCACATCCTTCGGCGCAAGTCCTCGACAGTGATAAGGTCCAGAGAACGCGATCGTCTGATCCCCTAAAAGCAGCAAAGCCCCGATCGCGTGCAATCGATCCTTTGGCGTTTCACGATACCACAATAATTGGACATAGACCCGCTCTGGAGGCAGAACTGGAGCGGCTTGAGGTATCCACGCTCTCAGCAAATCTGAAGTTGAGAAATCGTTGCCCTGTGCTCTCAAGTGTTTAATTCCAACCTGCTGTTTGGCAAGTTTTTTGCGTTTATAGTTTTCTCGACGTTGAGCATTAATCGTTTCCTGGTTGGCGTAATAGTAACGAAGCTTATGACAAGGATCTCCTGCCCAACAGCCATCCCCACCTTGAGCCGCATCATGAATCTGTTTTGCCTCGGTATCGCTGAGGGCAGAACAAAGTTTACATTTTGGGTCAGGATTTTTCGGCACGGATTCCTCCTCTATTCATCCTCAGTCATTCAAAGCCACTTTTCATCAAGTTTTATAAGAATTTAATAGTACAAAAATACCTAGAATTGATTAGTAATTCCGTACTTATATCGAACATCGTTAGAGTTTCGCTAGAGTCAAGATAATTGAATATTATCTTATATCAAAAACATTAGTTGATGCGTACTGTAGAGTAAAATAGGGGCAATCGCGCTATCTGACCTCAAATAGGTCGTGGAGTCTATGGAGTTGCCCACTGAGCAAGCCTCAATCCAAGCGGAAGTCCACCAGCCGGACATTCCGATGCCTCCGACCAACTTAACTTTTGACGATGGAGAACCTTTGGAAAGCCCTCGCCATCGCATTGCGATGAATCTCTTGATTCGCTCTGTCCAGTCCGCGTTTCACGATCGTTCCGACTTTTTTGCAGGCGGCAATATGTTTGTGTATTACAGCCGTACTCAAGCGATGAATCAAGACTTTCGCGGACCAGATTTTTTTGTGACGCTGGATGTCGATGGCAGTCGGGAACGGAAAGCGTGGGTGACTTGGGAAGAAGAGGGGCGTTTTCCGGATGTAATTGTGGAATTCCTATCGCCGAGTACCGAAAAAGTGGATCGTGAGGATAAAAAGCGCCTGTACGAACGAATTTTCAAAACTCAAGATTATTTTATTTTTGACCCTTTTGATCCTAACTCCTTACAAGGTTGGCACTTGCAGATTGGGCGGAGAGGTTATCAATCGCTCCGCTTTAATGCACAGGGCTGGCTTTGGTGTGAAGCATTAGAACTATGGTTGGGAACCTGGCAGGGGGTGATCGATCGCGAACCTGCCACTGGAACTTGTGATTGGCTGCGATTCTACGATCCAGATGGAAATCTCATTTTGCTTCCAGAAGAGGCAGAACGAATTGAGAAAGAGGCGGAGAGAGCAGAAAAGGAGGCTGAACGGGCGAGAGCCGATCGAGCAGAACAAGAAAACATAAGGCTGATCGAGCAACTGCGCGTTAGAGGAATCAATCCAGAAGAATTATTGGGAAATTAGCGGTACTGTCAATCGCTACCAAACTGGGTTGATATTCGTAAAACCCTTACACGGAGATAACAGGAGGAGTTAAGTTCAGGGGGTGACAACGGGGCTACAAGGCAGACTGAATCAGGGAAATGGCATGGAGACCTCGCTGGAAAAAGCGACGTTTCTGCGGCTTGAGTGCCATGAGTTGATGTGCCAACGTTGACTATAGATTGAGACTGCCAATCCACAAACTTCCATACAGCCCGATCCAAAATCGACTGTGGCGATAATGAGCGCGTTTCGGTTCTTTGACTCGACCGACATACTGCTGCACCTGTTTTTTGCGAATGCGCTTTCCTTGTACCGAGGCAAGCGAGTAAGCAATCGTCATCAGAACGAGTAAGGCAGTAAAACGATGAAAGTCAGCATGGCAGTCTTCAAGGTGATAGCCACCGGATTTGAAGTCCTTAAACCCCGGCTCAATGCAGAACCTGAAGTCGTAGTGAAACAACACTTGGTTGATATCGGTGAGATTGGTGAGCAAGTACCACACTTCGGGAGTTGTCGATTGAGCGTAAGCGCGTTTCTGATACATCACGAGATTGTGTCTACCAAAGCCGCGTTTCTGAGTGACTTGGATTTGCAAATATTGTTCGGGAATACCCGGAGATTGTGGTAGGTCATCGAGCCGCGAAAAGCCTGCACCTGCTTCTGGTTGAACGGTTGTACTCTTGGGTAAGCGAAATATGAATAACACGTTTTTCGCAACACACCAGGCAGCAAGCTCAATACTGTGAAACTCACGGTCGCCCAGCAAGACAAAGCGCCGTTTTTTCAACAACCGAAACACAGGTTGCAACACACTCTGTTGATCCCTCAGTGAACTCTGTCCTTGTTTGTCGAGCCACGTCCAATACAACGGAATCGCTCGATTGTGATACACGAAACTGACCATCATCAGGTTATGTCGGTTCCACTGCGTTCGGTCAAGCACGATTTGTAAGATTTGCCCACGCGGAATGTGTTGTTTGATCCACTGTTTAGCGATAGGAAACCACAACGCTTCGGGTGTCATCTGCGGCAGGCTTAAAAAGCGTTGTAGATTCCGTCGTCTACTCTCAAATAGAATCGGTTGTGGAAATAGCGTTGCAAGACGTTCAATCGTAATTCTGCGTTCTTGCTGCAATAGATTGACTAAGATTTCCAGCGTGATGAATTGAGCATCCGAGAGTTGTGATTTCAAACAGGATTGGTAGAATGAAGGCAACAT

Protein sequences of DBSCAN-SWA_1

>NZ_AP018205|131974:291391|274011_276153_+|WP_017291705.1|DBSCAN-SWA
MKHLRLPKPHFIRLDSISRRLNRNAVRVLPLLFGFILTLMLGTYSLAAEPKATEILWDTMGVPHIFGKDVPSAFQAFGWAQMQSHGNLLLRLYGQARGRSAEYWGKEYLESDRWVQTMGIPDRARQWYEAQNPTFRRALDAFAAGINAYATQHPDLIGDEVERVLPIHAVDVIAHSQRVLHFTFVVDPQMLAGLTDEEVPRGSNAWAIAPSHSESGNAMLLANPHLPWSDLFLWYEAQITAPGIDAYGATLVGIPVLAIAFNDHLGWTHTVNTHDGWDTYELTLSHGGYRFDDKVRPFEREEKTLKVKQSDGKLRKEKLMVRRSIHGPVIKEEKGKAIALRVVGLDQPGLLEQWWNMARATNLSQFETALRPLQLPMFTVIYADREGHIMHLFNGQVPVRKQGDFAYWEGIIPGDTSATLWTNYHRYDQLPRVLDPASGWLQNANDPPWTTTFPRAIDANDYPSYMAPRGPMNFRAQSSARMLTEDSRISFEEMIQYKHSTHMELADRVLDDLLRAATNDSSEIVRQAIPILKAWDRNANAESRGAVLFAAWVEAMNLSKAFATPWNENAPRTTPNGLSNPKSAVAALKTAATKVKTAYGALDVPWGDVFRLRYGSIDLPANGGPGKLGIFRVLNFVPNDQGQFESSDGDTFTAAIEFSNPVRAMALTSYGNATQPHSAHVGDQLKAFSQKQLRPVWRSRQEILAHLAERQTF
>NZ_AP018205|131974:291391|189095_189935_+|WP_086371080.1|DBSCAN-SWA
MYAIEKDINCTAWRQATMSEKNVSLTVAGLEVTTTEQANPAIPTWFAEALLLGQYWQHCGLLERLQQQVHVNRGRVGKYEVCDFVLLLLAYAVSGLTSLEAFFEQLSSVASVLMSVWGRQHCPVASTLSRFLADVDNDAVEALRELFESALLEHSPIDPELGVTDRSGKRWMVFDVDGTTKAVRHRVLLTQNTHPVLKRRSRNACKPGYAGRKRGEAVRTRTTIEQAHTREWLGNFAEAGNCNSKEDLKRSCTVIQRYCARSTSPVTALLRLEDVLKDN
>NZ_AP018205|131974:291391|133482_134337_-|WP_017291619.1|DBSCAN-SWA
MKRQHQTLVIGIGNQKGGVGKTTMTIQLAYALAEQGHKVLIIDLDVNAGSTKHLGIDPRAYLGTFEVLLGDEDPLTAIVTHEDEGHSLPESLHLLTGSRKLEELEERLRAKKSKFDDTPLHDVLKPVIKKLRGYYDFIFLDTPPSAPLPIVAAYKAADGFLLVAIPEGLAIQGLQEALHDIEEVRKYGNPDLQLVGLAIGAVDARTRLSRELIAYVDKEFKEYVLKPVIQRSTIIPTAQTQQKSIFQTHPDHAITQCFRDMAQEFKAKIARFFDRQTFDEVDHG
>NZ_AP018205|131974:291391|172312_175885_+|WP_017291651.1|DBSCAN-SWA
MELNSANLKGDLSQPPELSDRKEEATLRKKQIEEALWEREAQLTSIFQTIPNGIVILDQTGQIVSANPAAEQILRLTRSNLTERVYNDPAWSITTVDGQLFPEEDLPFVQVMRTGKPIYQVEHAIAHSDGTIIILSINASPLFNAEGRITNVIAAITDITERKQADAILRESEERYRSVIETAAEGIVFQHRDSRITTCNASAERILGLTADQMMGRSSLDPRWCAIYEDGSPFPGKLHPAMITLQTGEPQSNVIMGICKPDDTLTWISINARPLFQANDTEPYAVVCSFFDITDRKAAEAERFISEIALQQMPDAILLSDLEGRIQRWLGNAEQIFGYSATEAMGQPINFIYHPDVRAAMTTEIMQSVQETDEFSREILCMRKDGSEVPIETTIKTVCDKAGKPLFLIGINKDITERKRAEIERIQLLRQQIQEQTARLEVEAGLRRSTFLVEAGTLLASSLDYEQTLQSVASLAVPYFADWCGVDLLNHDGSISRVAVAHADPNKVKFAWEVAQRFPRHLEDGYGISQVMKTGHSEIAIKITDEQLTATVPIPEYLEIIQELGLKSCIITPLQARGRVVGTLSLVFAESNRQYSMADLDLAEDLARRAAIAIDNARLYHRTQQAKQDALSAANRITRLQRVTAALSESLTPEQVIEVVVEQSVAVLKAAAVLVVLVSKDRTELEIVKSIGYEADLVQSWCKFPINTDVPLAEAVRTGQPVWVETLLERIARYPHLAEIYSRYDFQSWIALPLVVEGKSIGGMLLSFKEFKNLSQEDREFILALSRQCAQAISRAQLYEAERSSRAEAEQANRVKDEFLAVLSHELRSPLNPILGWTKILRAGQLKPDKVDQALATIERNAKLQAQLIEDLLDISRMLRGKLSLNIVPVDLITVIHSAIETVQLAASAKSIQIQTRLQQHSKSVLGDANRLQQVLWNLLSNAIKFTPNEGQVIIGMEESEQHIHIQVIDTGKGIHPGFLPHVFEYFRQADSSTTRQFGGLGLGLAIARQIVELHGGTIQAESLGEGLGATFTVRLPITTVVAESPTAGESSIQIEDLTGLHILVVDDEADMRDLAEFILVQHGAQVTVASSAADALLTLAHSVPDVLLSDIGMPEMDGYVLIRQIRERSPEAGGRMPAIALTAYAGEIDQHRALAVGFQRHIPKPVDPETLIRAITELLKNRLGEVEQQ
>NZ_AP018205|131974:291391|162453_166188_+|WP_017291649.1|DBSCAN-SWA
MNDPSIRTNPHLDEVNALRQRLRDLEQSHNQCQQQLQQLQQQLSRERTERKQTEAALRGSEERLSVANERFQLAAKAVNCLIYDWDLERDRVERTDGLTRILGYSLEEAEPTGQWWRDRVHPSDLSRIQEQALVTLTTHDYFAAEYRVLNKSNQYIDVLDQGLVVVRDSDGNPTRIVGSTTNISDRKQAERQLQESQRFIQQIADATPGTLYVYDMLEQCNVYVNRQIGELLGYTPEDIQRLGDQLFPQLMHPEDFANLGLQIQRLDQAQDDEIVDHEYRMRHANGEWRWLWSRNTVSTRLSDGRAHQVVGTVYDITARKQAEAELLNREQEFRTLVENTPDIVIRYDRDLRHLYINPSVERALGIPPEQFIGKTGFELGFTDERSQRWYAILQQVFETGQRQSIEYEFPNSCNELRSYRVRFVPELIQGGQVTTVLAVATDVTEYKRAELSLRQSEERVRLAMEGAQMGTWDVDLNTGKAIWSVQHFTMLGYEPVATGEASEDMWSSHIYPDDRERVLAEWQRAREEQRLYRAEYRIIRADNQQIRWLAALGSFTYDTNGLPIRSIGVLFDISDRKQVEADREQLLHELSTERAQFEAVLRQMPAGVIIAHAPSGKLILGNQQVEQIWRQPFLSANNINEYGVYQGFHPDGKLYQPEEWPLARSLMTGEIVDQEEIRFVRGDGLKGVINVSSTPVYNSHREIIAGVVIFQDVTSRKQAEESLRQSEERLRLALLVGQSGIWDWDIAHNHITWSEQIYQFHGLTSETFSGKVEDFAELIHPEDQAKVSKAIDQALRERSGYEMEFRAVHPTGEIRWLSTRGGVIFDQQGSPARMLGATIDITERKAIEVEREQLLRREQIAREQAEVANRIKDEFLAVLSHELRTPLNPILGWTRLLRTHNFDPQATDRALETIERNAKLQAQLIEDLLDVSRILQGKLRLNSFPVNLVTTIEAALETVRLSAEAKSIQIQTILHLEVGQVNGDANRLQQVVWNLLSNAIKFTPSGGRIEVRLTQSEAYAQIQVSDNGQGIRPDFLPHVFEYFCQADSSTTRQFGGLGLGLAIVRHLVELHGGRVKAESPGCEMGATFTVELPLMVSALTPDLAVAPSQETKNLKSVRILIVDDEADMRDLIRFILEDQGATVRVAASAAEALQQFTESMPDVLISDIGMPNMDGYALIAQIRTVLSKQGKTVPAIALTAYAGEVNQRQALAAGFQLHLAKPVDPEQLVKCVSQAIGSSFKPSS
>NZ_AP018205|131974:291391|205287_207657_-|WP_086371077.1|DBSCAN-SWA
MNKLLSLNPMVINDLRLLDLVPVATYVCDRRGQIQSFNQAAIEVWGQVPNAKATDEAFHHAFNLLNFNGQSVCYADTPIAEVLRTGKAVKNRALLIQRADGSEVAVLINAVPIVDNQTLVGAIASLQDITEQHRTERLLQSVLDNTPGVIYIKDQEGRLLMVNRHFAQLAGRSVEEIVGKRDREIFSDPNLEEILENDRRILAENKLVQLEESLDLPDGRHTFLSIKLPAEDVGFPGKVLCGFTTDITDRKRAESALHQSEERLRIAQQAAKAGVWNWDIVTNQVTWSAEYYQLYGLDPATTQPSYDNWLDSIVEQDRDRADRIARESLEHQSDLNVEFRVHHPIHGARWITAIGQTFYDADHQPIRMTGIALDITERKQAEAEREHLLRREQAARAEAQAANRIKDEFLAVLSHELRTPLNPILGWSKLLQSGKLNQARTLEALTTIERNAKLQAELIEDLFDVSRILQGKLSLNMVPVDLAATIRAAMETVRLAAEAKSIQIQTELDTSVRKILGGSARLQQVVWNLLSNAVKFTPTEGRVNIRLENLGDQAQMIIRDTGKGIAPDFLPYVFDYFRQEDGATTRKFGGLGLGLAIVRHLVELHGGTIRAESEGEGRGATFIVRLPLMPTQAETDTESLEPDLTLGLDGIRVLVVEDETDTRELIAFLLEQAGAQVLAVASGFEGLAVFTQSKPDLLLSDIGMPDMDGYMLLQQIRALPAEQGGKIPAIALTAYAGEMNQQQAIAAGFQHHLAKPVEPEELVRVIASVNAANAHRMKSSRAKEKNDGH
>NZ_AP018205|131974:291391|284993_285239_+|WP_017291713.1|DBSCAN-SWA
MPRFSLLILVNLEVNIQPFFTVETMPKKAIAAQLIQDCGYDAIDAGGLMVSRSLETLATAWVQFAVVSNLFPNVGLKALRR
>NZ_AP018205|131974:291391|140666_141365_-|WP_017291626.1|DBSCAN-SWA
MEIGKYADGNWIGARFLRIEPRGFTLNQFSFFRRVIAMSYSFVVIELHVLIRRVAIDYVRFGYYRYAMREIPAGKDPLHVDAKLIETYDITQCRMTRTRRKRQGLANVVFVRQGHRFILLATEGKHPAFDRICWRDIRIAPIHFAGYSIGMKGGVPCVQVARRTWKPIERYLFAIAHRPKSEVEAAMNNLRFYSFPGVIRQKLKLVKTMNRMRRKSHRPRVELHLRLERKAD
>NZ_AP018205|131974:291391|253714_259201_+|WP_017291699.1|DBSCAN-SWA
MKMDNLEDIYELSPLQQGLLFHTIYAPQSGVYFEQFSWTLKGNLNATALRQAWQRVVDRHSILRTAFYWHDLEKPYQVVYGQIDLPWHQEDWRHFDPETQRDRLDEFLRVDRQTGFELSQAPLMRLALLRLADDAYHLVWSSHHLLLDGWSESLIFKEVYAFYEAFCQGQDLHLSQPRPFRDYIAWLQQQDLAQAEAFWRQRLKGFTAPTRLAVDRNAHNLPSQEEDYDWQRIDLSEATSIALQDLARQHQLTLNTLVQGAWALLLSRYSGESDVVFGVTSSGRPTDLAGVESMVGIFVNTLPLRVQVPPDASLLPWLQQILAQQMEVLQYEYSPLVQVQGWSDVSRNQPLFETCQVLENYPVDATVKNGVEGFEIQNPRSFEKTNEPLRLLAIPDAALRLELWYDTRRFDRATIHRMLGHLQTLLEGFIAHPEACLSALPMLSNEELQQLKVWGEGAVQPASGECIHHLFEAQVDRTPDNIAVICADQQLTYRELNDRANHLAHSLQTLGVKPETLVGICVERSLEMVVGVLAILKAGGAYVPLDPTYPAERVAFILQDAQISVLLTQQTLLSTLPDTPAQVVCLDAKTNFPETLEINQNPQSAITPANLAYVIYTSGSTGQPKGVAIEHRNTIALLHWAQSVFTADQLSGVLASTSLCFDLSVFELFAPLSVGGTAILAENALHLPTLAAAEQVTLINTVPSAIAALIEMNGIPKSVQTVNLAGEPLPHKLVRQLYERSHIQQVFNLYGPSEDTTYSTFARIDPQIEGTPPIGRPIANTQVYVLDQQLQPVPIGVPGELYLGGAGLARGYLNRPDLTAEWFIPNPFSAPDFADRLYKTGDLVRYLPDGHLEFLNRIDHQVKIRGFRIELGEIEAALSQHRAVQDAVVLAREDVPGEKRLVAYIVPQSLDRHASSQNLEDQQVLQWQMVYNDDRFRDTQTEWEPTFNISGWMSSYTNQPIPAEEMREWVDATVDRILALRPQRVLEIGCGTGLLLFRIAPDCTEYWGTDFSHIALSYVKRVLSLPQYQLPQVRLLQQQADQLEGIEPHRFDTVILNSVIQYFPSIDYLLRVLEHAVNAVAPGGTIFIGDVRSLPLLEAFYKSVELYQASELLTPEQLRDRIQRRRLQEQELVIDPAFFSALQQHLPQIEHVQIQPKQGRYENELNQFRYDVTLRIGANVEAQTGKTEERSWQTYANNPLQQQTTREFVGQLRDYLHQKLPDYMVPSAFVLLEALPLTPNGKLDRRSLPAPDRQESTETATAPRTPIEEMLSGIWAQVLGVATVGINDNFFELGGHSLLATQVISRVREVFQVELPLRCLFEAPTIAALAQQVKVAIQSQQGLEAPPLLPVPRDRDLPLSFAQQRLWFLHQLASDSPLYNDPVALRLGGLLNVTALKQSINEIVRRHEVLRSRFDTVQGQPVQIITPSLDVPISMVDLGDLPEPEREAEALRLAIEEAARPFDLSADPLLRVTLLRLSETDHVVLLTLHHIVSDAWTMGVLVQELSALYAAFSTHQPSPLPELPIQYADFALWQRQWLQGEVLQAQLNYWRQQLAALPTLELPTDKPRPQIQSDRAATQTFVVPKEVSRSLIQLSQQEGVTLFMTLLTAFKTLLHCYTGQTDIGVGSPIANRNRAEIEHLIGFFVNTLVLRTDLSNNPTFRSLLARVRETTLGAYAHQDLPFEKLVEELRPERQQQHSPLFRVWFVLQNAPMPPLELPGLTLTPFDVDSGTTKFDLALFFFETSEGLEGCFEYNADLFDTSTIAQMVHQFEALLQTVVAQPDIQLSVLSNQVAKAAKEQQLLQAQAISATNLQRLQRITRKPLSRAKS
>NZ_AP018205|131974:291391|193269_193374_+|WP_086371079.1|transposase|DBSCAN-SWA
MHCRRLVRDYELLPETSETWIYLAMIRIMVRRLA
>NZ_AP018205|131974:291391|286488_287733_-|WP_017291715.1|integrase|DBSCAN-SWA
MVARSLPQVEAHLIPLPLDDRTSPPRQKGKVATLRLPPTDIRSVKVREFLNAGGFEPNTRRNYERELYRFLLWSELLWSEIKPHHLNAHYLRYLTEEVRTSQGKPLSTSSRNLAVMALRSFFAWLHKTYPDLVPTNPAIGLKGKAIPLPEAQSLTEEEQALVWSAVDQRGETQLRDRALIHILSHGLRAGEVVDLNLGAIGNHTTDGFSGKVLFIADTKTDRPRIVPLDPASWVEIDSYLNWRRSQGEELSCDRPLLLSHHVTRRGERLTYHGIYFAIEKIGELAEIQNLHPHLFRHTYLTELLLDDIDPTHARRLGGIESESVFRRYTLRAEQEAAINAFFRNCQKRQQSLGSAGLNNALPFAPLKTEDQAQAEKLKIARNLLREGVALEIVARSLGLSFQTLQDLQYAEDFA
>NZ_AP018205|131974:291391|221479_222283_-|WP_017291687.1|DBSCAN-SWA
MTNYVLISDGQLALAAMLILINLILSIVLQLGLEKQLWIGSIRMTVQLLLIGYVLKWIFALQSSWSVLSVALIMTLLAGQSAIDRTKRRYQGMYWNSFVSIFTSSALMLGAIVSGIIRVEPWYNPQYIIPMLGMILGNALTGTSLALDRFTEDLTVRRDQIESLLALGATRWEAAQGTIREAVRTGMIPTINQMMVMGTVSLPGMMTGQIIAGASPTDAVRYQIVLIFAIAAATGLATIGIVLLGFRSLFNIQHQLRLDRLQFKQKL
>NZ_AP018205|131974:291391|143350_144001_-|WP_017291629.1|DBSCAN-SWA
MDERQRLHAALQEALVAPVKADCRSLCQLLEDAIALQPDAVCLQIGGDAIALIAEVLYLKMMAYQEVNKTDVPDEEDSGFPVLDDDDHAYERHTMSLDLESDEEEWGKPKKVASRRAPNDSVAAPVPPKRVLKMLQDLAGDEDPTGWSVAISAWLKRKKINEPIPIAQIHQSMRKLSIVELWLGLLLGGFLIEEKPNTDETFYHDISDGAVWLIQQ
>NZ_AP018205|131974:291391|143993_144593_-|WP_017291630.1|DBSCAN-SWA
MLWAVSKTWQNARQGNRSMARPINPKCLECSAYSVEWARVEHGPNGDGCWVEEENRCEKLRWQYQNRAEQNAKRRLEYRLRQQAKQTVAQVSFPVAQRPTPIRIIFSEEPDNFKKNVTLVHAIEFQLWVGTECYTKREPIACWGMRGDEVAKLMEEILTEFTAQYSATLNQGKHFKKFVTIHKHIRECKINHPWSLQHG
>NZ_AP018205|131974:291391|227196_228240_+|WP_071596259.1|DBSCAN-SWA
MTTISRLVRSLLLFALTILLVWGCNRTLSTTPHLTSEPIQPIQPAANCQSIEHAAGSTKICRQPQKIAVLSPYLLDILLSLGEQPAGYAGTSIGQGQFDHPAHQIPYLGNRIITQPMNLGDRTYPSLEALASLKPDLILGELWQGSQGKYDLFSQIAPTILIDDQQGGWQSNLQLIAKAMGRLDVIQPLMFAREQRMSAARQQLNAIVQANPRILLLSSGDLANGFYAYGQDRSVYSDLLEALGFKMTRLNDSMLEAIGAAPLSLEMLPQLDTDMLIVLGWDSNPNQNSLAWKRLQQKWNQTRLLKALPVSQAGRVYFMDGHLTMLRGPIAEAYILNDLLKQLTSKM
>NZ_AP018205|131974:291391|285407_286100_-|WP_026149075.1|transposase|DBSCAN-SWA
MYSRHRFPGEIISYCVWWYYTFPLSYRDTEKMMLYRGIEVTYESIREWCQKFGQQYANQLQRKRRYITDKWHLDEMVVTIKKQQYYLWRAVDSEGNVLNVLLQRHRDTEAAKRFFRKLLKKQGFVPRVMVTDKLKSYEAAKKQVMPSVEHRQHKGLNNRAENSHQPTRVRERRMRRFKSPGQAQRFLSAFDPIRSHFHPKQHDLSSKRYREQMRQCFEDSWEITCVKDAA
>NZ_AP018205|131974:291391|289350_290151_+|WP_017291718.1|DBSCAN-SWA
MELPTEQASIQAEVHQPDIPMPPTNLTFDDGEPLESPRHRIAMNLLIRSVQSAFHDRSDFFAGGNMFVYYSRTQAMNQDFRGPDFFVTLDVDGSRERKAWVTWEEEGRFPDVIVEFLSPSTEKVDREDKKRLYERIFKTQDYFIFDPFDPNSLQGWHLQIGRRGYQSLRFNAQGWLWCEALELWLGTWQGVIDREPATGTCDWLRFYDPDGNLILLPEEAERIEKEAERAEKEAERARADRAEQENIRLIEQLRVRGINPEELLGN
>NZ_AP018205|131974:291391|273221_273977_+|WP_017291704.1|DBSCAN-SWA
MHSNWIIRSKPNPQARLRLFCFPYAGGSASIFRSWSDQLPQNIEVCAVELPGRGTLMRLAPYTQLKPLVEAIAQSLLPNLNQPFALFGHSMGALISFELARFLRQAYGLTPRHLFVSGRAAPYIPDRDPPIYTLPDAAFIQELRRLNGTPEAVLQNQELMQLLTPILRADFAAIDTYRYQPEPALGCPITALGGLQDLEVSRDDLEAWQTQTIAPFQIQLFLGNHFFLHSAQSLLLKAIAQQLQAVEPAIG
>NZ_AP018205|131974:291391|155025_156072_-|WP_017291643.1|DBSCAN-SWA
MSTDDLPLKNLQLKQVTHDLRSSVADLNTVNPWIGLLRFCTLGFVCLSLIVLAWLSQTSWGFVGYSAIAGFVYAIWFICTHDATHHTLTGWVWFDEALPRLMSYPMLWMHSVYAQIHRLHHGWNGTNLQDPERVQWTLEEYENASVWMKWYVRHQWQVDLFVLGGLGMIAKTIRHGWQFGKTIPAVRRALLFDAIGIVLVQASFLTVALFTQHLWQYIIFWCILERVIGVVVQARDHLEHYGMWSQAPGHQLTQLYSSRNLTVHPIVGWLVGGLNYHSVHHAFPSIPFDQLPEAFRRIESVLKQHDLPPMTVGCGYVKEVSRLSTQPSAIGTDQVDNLTGRYQMLNLS
>NZ_AP018205|131974:291391|231019_236284_+|WP_017291695.1|DBSCAN-SWA
MHQPDRLAFTFLLDGETEAVSFTYKELDRQSRAIAARLQAMGLGGERALLLYPPGLDYLAAFFGCLYAGVVAVPAYPPHNQRNTPRIAAILSDAQAAIALTTTAILDRMQSLLAEKMNGDTIQWLTTDNLEYSIAETWQEPLIENNTLAFLQYTSGSTGTPKGVMLSHSNLLHNAAATYRYMEHSPSSTFVSWLPAYHDMGLIGGILQPLYGGFPCILMSPASFLQRPYRWLQAISRYQGTTSGAPNFAYDLCVEKITAEQRQTLDLSHWSVAFNGAEPIRHSSLERFAATFAECGFRREAFYPCYGMAEATLMVSGGVQATAPVIKTVQKAALERSQVVEADAGDAEVWTLIGCGKTIPEQHIVIVHPETLDRCQPGEVGEIWVSGSSVGQGYWNRPEESAQTFQAYLSDTHAGPFLRTGDLGFLHDGELFITGRAKDLIIIRGRNLYPQDLEFTAERSHPTLRIGSSAAFAIALYDAERLVVVQEVEFRQKPNVQEVTQAIRQAIAEAHEVQAYAVVLIKAGTIPKTSSGKIQRRACKAAFLAGNLAEIGSSILEMVEVENLETSLTRADLFAFDSAERETQLTDYVRQQVARVLRIAATQVDVQHPLSRFGLDSLMIFEIKSRIELDFGVEIAIADLFEGASIAELVAQILNQLTTSNPQSACPIVRVKSATNCYSLSFAQQRLWFLDQLEAANSAYHIAIAVQLQGELNITVLEKSLTEIIRRHEILRTTFCTIAGQVMQQVTDAQILPLTVVDLRSWVKSEQEVEAQRITKQAIQQPFDLQQEPLFRATLMQLGQEDHQLLLTMHHIISDRWSAEVMLQELATLYDSYSQEWVSPLPELPIQYADFAHWQRTWLQGEVLETQLAYWKQQLNSAPTVLHLPSDRPRPAAQTFRGATKSLHLSRSLTNSLKALARQEGVTLFMLLLAVFKTLMYRYSGQDRISVGSPIANRNRNEITGLIGFFVNTLVLHTDLAGNPSFRELLNRVRQVALGAYTHQDLPFEQLVEAVQPERNMSYSPLFQVMFTLQNAPQLPEIPDLALKPIKVTSETAQFDLSVAVETVENGLVADFEYNTDLFDESTIARMQHHFQTLLESIVTNPNARLSDLPLLTAQEQQQLWQWGNQAVSLNPNPDLCIHQLFEAQAKRTPDAIAVIFEQQQLTYQDLNNQADHLANFLRSLGVAPEGLVGICATRSLDLIIGLLAILKAGGAYVPLDPNLPKERLALMLEDTQVPVLLTQTSLLNILPETTARVVCLDSAWNLSEQQSAEHCAPVASNLAYVIYTSGSTGKPKGVMIEHRSLVSYIETASVEYGIKPGDRVLQFASLSFDVAAEEIFVSLTQGATLVLRTDAMLDSVSTFLQQCRELALTVLDLPTAFWHQITVELAQGLELPESLRLVIIGGEPALSERLLAWQMKVRDRVQLLNAYGPTETTIGATICDLSTVSPANSGRIAPIGYPLHNTQLYVLDQNQQPVAIGVPGELYVGGGGIARGYLNQPELTAERFIPNPFDRNSTLLYKTGDRVRYLPNGMLEFLDRIDDQVKIRGFRIELGEIEATLRQHPDVQEAIVLAWADHSNNKRLTAYIRAATPPTPIDLRHFLEEKLPQYMIPATFLFLDALPLTPSGKIDRRALPAPETAQIASTSTYVAPKTEVEQAISEVWQAVLQIEKVGIYDNFFDLGGHSLLVLQVQSKLQIALKRSISVTDLFQYPNISALANYLNQTSSSKVSLQAVRDRAAQQRAAFNRQKQLRQSGK
>NZ_AP018205|131974:291391|283993_284725_-|WP_017291712.1|DBSCAN-SWA
MTEEVATPQPEAPQPAAVPQSSHPTPRYGAMTVAEGWAKSRHKYAGKDFKIMDDESVQCPAGHRMSRREIRYTRRGDMQMLFSMNPRICASCPVKQHCLSDDSKNTNGRRISVIRTKLPPVPTVAVEPEITIIAQAPMKTVQGTQALIWTDIPATQLRREIRQHLRRHQSRIEQSNSAIQTIEPAISYLTRSQRAHRRLAWAERLKRNAARSNTLQISVEIFGVSPKLIEFLNCLSDKRSESS
>NZ_AP018205|131974:291391|181180_182149_+|WP_086371083.1|DBSCAN-SWA
MPWEQVLTWSFVIALLTAGIRLAIPVLLAVLGEIIAERSGVMNLGLEGVMLIGGLAGFAVAASLEQATGNASLAAWSGLAAGLFGGALMGLLMAVLTVSLKTDQVVTGVTLVLFGQGLTAYLFRSRIGLSGTRVQGLETWAIPRLSNFPIIGEILFNQTAIVYLTALLVYVCWFFLFRTNAGLSLRAVGENPAAAETSGLNVDRIRYLAVIAGSALAGLGGAVLTVVQLRLFTEGIMAGRGWIAIALVFFSRWQPVWALFGALLFGVADALQYRIQALGSKDFPYEFLLMLPYVLTLMALLRGTGRSETPASLGIPYVKEDR
>NZ_AP018205|131974:291391|153501_153825_-|WP_017291640.1|DBSCAN-SWA
MSHSLDPTEDAELVQAVQESLQQMSIELEHPQDAEAIQQLYQKAQRLLSHLAPDPLTVARVTGVLLVYQLPGTEPEEVKWFEGELQNSSDLESIEELVDSIFRPDAL
>NZ_AP018205|131974:291391|214443_215208_-|WP_017291681.1|integrase,transposase|DBSCAN-SWA
MTIEEAEPVPVPDNAGVKVRSRSLTLAEQERVKSMQRLANAPDRPTYLALQQEVAQQLNMTVRNVQLLMKAWQTKGVDGVVRQERSDRGERRLDEDWSDYILETYRAGNRGGRRMSRAQVAVRVAARALEIGDSHPSSRASVYRVLQSEMDRQEERSRSRSIGWSGETLLLKTREGLEVEVKESNQVWQCDHTRADLLVVDQMGEVLGRPWLTTIVDTHSRCIIGINLGMEAPSAVVYAASTTGTCPLLVKQAS
>NZ_AP018205|131974:291391|136287_136509_-|WP_017291621.1|DBSCAN-SWA
MTFSEWLCFKRKRSQIRQKDLASALGLSKQTISSWETGESFPKLTPLQMQILCEKLDCSLSELASYQAVAEAP
>NZ_AP018205|131974:291391|260280_263550_+|WP_017291701.1|DBSCAN-SWA
MQSASIDRQQDTIEGYSLSPQQKHLWKLQQRDQHQPYRVQVSVQIDGAFDRERLKLALQNVVDRHEILRTTFKCLPGLTLPLQVIGECDFSWYSELNLSDRTAQVQVSQIEALFQEFGQLPFDFEQGSLFRVALVMLSAQKHMLLICLPALCGDGVAVKNLIREISQVYRACTQNQELTDEPLQYADIAAWQNELLDAEESETAKRYWRKLAIAEALTVKLPYERSTTKSSTFQPHVFSATIASPLVAEINEFAKTYECSTETFLLTCWQILLWRLTGQSEVVVNTAFSGRKYEELEPAIGTFVKYLPLYGQLSDRAQFINVLRKTEELQREADTWQEYFAWEEEARDPSILPFGFDFETLDLTSCGSELSWSIDRFSVCVDRCKLRLSCIDRHDGLTTDFHYDATVLQAEDIQRLAEQLQTLLESVIYNPQAEICTLNILSDRERHQLLVAFNHTQFDYPNQCFHHLFEQQVDHTPNNIAVVCGDQHLTYAELNARANQLAHYLRSLGVKSETLVGICVERSLDMLVGILGILKAGGAYVPFDPAYPQARIAFMLEDTQAPVVLTQARLLDRLPDTSAQLVCLDSAWETIERSSAENPPSSLTPDHLAYVIYTSGSTGKPKGTLIPHRGLVNYLCWCTQAYGVEQGEGALVHSSIAFDATITGLFAPLLVGSKVELLPEDLGIEALAIALQTKSNYSLIKITPAQLELLAQQLPAETASHRTQMFVIGGENLTAQHIAFWQTAAPETALVNEYGPTETVVGCCVYWVPSDQPSTGSIPIGRPIANTQLYLLDRNLQPVPTGFPGELYISGAGVARGYLNRPELTAERFIPNPFCSGSRLYKTGDLAQFLPNGTIEYLGRIDHQVKIRGFRIELGEIETVLAQHPAVQQAVVIDREDTPGDQRLVAYLVPAPSATPNASILRPFLQEKLPAYMVPSAFVVLKKLPLTSNGKVDRKALPAPEQVRPELEAAYIAPRNSIESTLAAIWAEVLGLEQIGVYDDFFDLGGHSLLLTQVTSRIHNALGIDLPMRQLFDAPTIAALAEVIADKQLEQADHDLLAHLIADLEQLPEADVKAALIAETSSTGSIDHE
>NZ_AP018205|131974:291391|193377_194724_+|WP_086371078.1|DBSCAN-SWA
MTDSGFSNTLLDGLYGGANYVTLLQQRQMTYITRCRDYHLLKEPTVKAILATAPQQQYLHPDSPEITRDLFDIECLDATRRGYLEPMRLIIVRLIRFSKQKPSVGKCEGKYLYELFLTSLPPSCFSAADVLSLYNGRGGFEQTLSEEDREQDCDRWCSWQPEGQSFWQILSQWVWNWRIQAGWQSQAQRQIRQTLWSPALDQLETQECSAPTIAPQSLLSTPTVNPQLAPSPKYGAMVAVPGWGQSRHKYSGKDFKIIDDEAIECPAGHQMDRQEVRYNRVGDMQLVFGIKATICRICPVIQHCHADRSANTRGRRIWVTRAKLPTPPLLAEVPEIIVKQSLSALNVGTQAIIWTDIPATQFRRKLKCNLERNQIQIEAVSAHRQAIDSAQPLLTRQQRAHRRLSWEQRLKRNQLQGKAVNWKVQFFGISSSLAEFLKCPHIPGFQRS
>NZ_AP018205|131974:291391|135034_136240_+|WP_017291620.1|DBSCAN-SWA
MHSTQSSSPIEGGYCLLSQATLTNVLGALIDRAISYRAARVFFACCSMRSIREAAARCQIRKHQKIQFRFDEIRQRVGTQSEKLIRADLKQLERSGLLSFTQDAIEVVTVPINFTQSFDLGRSMRRLIPVPRRILEYLAQCPSPSVLRGIIVYVLRGLTLRQGIVYACGSVKSSWVAQIAHISLRAAKSVRAHLIEIGWLTKDTGSTQRKLNATGAFFRINTQWRRSSSTTKQPRAVDNSTTSDSQSAPLIAKLGSKSAPPIQDLKTSTNSKDQKSSKSLPGVYQQTQKISPPILHNIQANDLYHFHRLELLYWQAIAAKWLIHSEASTLNWICAAVRAREVVKRSGGNAVKVFVTIVRRKLWNTITGTQEDYARKSLVRFRETCPQLFRHRSESDRRISV
>NZ_AP018205|131974:291391|153947_154517_+|WP_017291641.1|DBSCAN-SWA
MLSDETKQQLEQERSRLVNDRRKIVSEIESSVSAQVDRTLQALNALLDVLAKVEVPAVDDIVESVPDILEHATTEVPTQSVPRPRKIGTKSTAKPKGKGKTSQSQAFDAKHLKGSFNGKSLRDAILEVMQQDAARVYATDELIVALYDPFEEADLPIARRTLGATFMHLIRAGKAEKVQDKPPHYKLSR
>NZ_AP018205|131974:291391|144861_145326_-|WP_017291631.1|DBSCAN-SWA
MPPEQWQRLSCGQGSKGEREYEWARVAINCGDSGRFQRWLVFRRSLEQIDPPQHVSYYQVFAPKDTSLATIAKVAGKRWGIEECFKLAKSQLGLADYEVRSWVGWHRHMTLVLAAQAFLTVLRAQVEPLIQCSHSASPPLALVGSPVAFKVFRG
>NZ_AP018205|131974:291391|287756_288479_-|WP_017291716.1|DBSCAN-SWA
MDSQQLELDLRRSLEVATAFPDEKEVLTSVWQTYDQWVEIIASQSASVQLELAGEILQQIAELICLRSDVLIEDWKQQHDPVEPIVDISGRVDLVMQTQEFNLSRLVEYDLPAPYPEYRKSPIKIEPTESAAGPVNSAQLITVMGEQLRQDAKLTDAEAAAAFKAAMETAHDEDVAQWTEAIVTFWETAQVHAIPFVELCQQLNQPWIEVWLALLLGGFLLELRGDWYDGEIWIVGHTQR
>NZ_AP018205|131974:291391|182172_183147_+|WP_086371082.1|DBSCAN-SWA
MIDPILWNDWHPIARSSDLKPGTILRSRLLDTDIVLWQGENTNVIAWEDRCPHRSVKLSGGKIFENTLVCPYHGLAYNPEGQCVKVPAHPNYTPPKQACVKSFAVEERYGVVFVSLGSPSQPIPPFPEWDDPSYRTYLSGGHYCRCSGLRAIENFLDVAHLPFVHAGILGEPDKAVIEDYEVTSIDTGIYMKDIKIWQPDPDGTGRGGVAAYDYWTIRPLTVALRKQRASGQKMVLLYCVTPVSEEECIGWMWGTLNYAHDIPEEVMVAFQDKVILQDVDNLESHHPKRLPLDLQAEFHLPSDRASLGYRKWLKQLGVTYGAIP
>NZ_AP018205|131974:291391|183265_188629_+|WP_096735605.1|DBSCAN-SWA
MVMLPGYEIVEKIYESSKTMVYRGVRSNDQKPVVIKALKNQYPTPREIAVFRKQYSLANHLGILGIVRPYSLENYENQWALVLEDFGAISLRDYCKTHSLSLKDFLSIAIQTTQILGELHRNRIIHKDLKPANLLINSTTGQIKITDFSIASILPKENQALISPNGLEGTLPYLSPEQTGRMNRGIDYRSDFYSLGVTFYQLLTQQLPFISNDPLELVHCHLAKQPISPAELNSAIPVPLSNIVMKLMAKMAEDRYQSATGLLHDLEVCQQQFQLHNTIEAFLLGQQDFCDRLSIPEKLYGRETEVAQLLTAFDRVAQSGFSEFLLVSGYSGIGKSSLVQEVYKPIVQRRGYFIAGKFDQLQRNVPYSAIASAFGSLVQQLLTESELQLRQWQEELAIALGSNGQVIVDVIPELEQIIGKQPEIAALNPTEAQNRFNRVFQNFIRVFCQPEHPLVIFLDDLQWADSATLRLIKLLLTDSQTHHLFLIGAFRDNEVNATHPLTLLLEGLQFQAFPIYQVTLKPLSSAHVTQLISDTLRTHEVSPFVDLLMRKTNGNPFFINEFLKTLYQDELLRFDFYKNSWQWNLKEIETLNSTDNVVELLVDRLRKLPDATQQVIQFAACIGNRFDLKTLSIVLQPSTLETTAQALSIAVQQGLIVPLSALEIVQSDTTEPILVSDRYKFLHDRVQQAAYALIDDREKQSVHLQIGKLLYANYSESSEQLFELVGHFNLGQALITQADEKTQLAHLNIQAAIKAKQAAAYSFAQACLIHAQNHLTETAWSEHYELMFTLHREQAEIEYLLGNFEQSERLIEMTLKQAKSALEKAEIYQLLIVLYTMQGKYQPAIETGRVALSSFEIDIPESELYKAFEDELAIAKTQLAQQKIPALLDQPEMMIPEKRAAARLLTTLGAPTYFSNHDLWLICVMKLVNLSLKHGVISESTYGYSEYGLILGSMLGDYRAGYQFGQLSLKVSERFNNQAEKCKGCVVVGGSVNHWIRPLKEDAEIFMEGYQAGLESGELQFAGYNIAHQVINLFYQGADLDSLQDKLLNYLAFTEQTQNQLAKDMLLACQLIFHSLQECDVRQCKFVTKELSETEYLAACEARSSFAAIGFFKILKAQVLYLYGCFEDAHHVIGQARHLLNYLPGCISLAEFIFYDSLILTSLYLTASELQKSEYWQQIITNQQQMEIWSATCPENFRHQYLLVEAEIARLQNDSMTAIDLYDEAIALAKTNGFVQDSALANELSAKFWITTGKEKLAQIYWIEAYHLYQSWGASTKVADLEQHYPHLLVLGNSSVELSHIADETLSITHISSTSTSSTQILDLSTILKASQAISQEIQLDRLLESLLKVILESAGAERGAILLPEEDHWNIAVQGNSDHTDVILQPLTEEMLSLSIVQYAARTQQRLVIHDATKEPICAADPYVLTHQPKSILCFPIAHKSKLSGIIYLENEQTTEAFSRDRLKVLSLLSTQIAISLENATLYQTLQASEARERERAQQLEKSLQDLQNTQAQLIQTEKISSLGQLVAGVAHEVNNPVGFIAGNLNHTKQAVEDLIGLVQLYREALPQPGKEIENEIDAIDLDFLIADLPQMISSMKLGTDRIREIMQSLRNYSRMDGSEKQLADLHKGIDSTLMILSHRLKATPEHPAIQVIKDYGDLPEVPCFAGQLNQVFMNLIANAIDALEEANRGKSYSELEVNPNCITIQTSIENNDAVIRIKDNGAGMPYEVQQRIFEAFFTTKPEGKGTGLGLPICYQIVREKHGGQLSAVSAIGEGTEFVIQIPIHS
>NZ_AP018205|131974:291391|150577_152647_+|WP_017291638.1|DBSCAN-SWA
MALDRTRPTDFKTLRLRSLKVGLLHSAIATGVIVGLLALFPQIARSPLLCYLLGCPVFVFYLRVLGVGCDIFFVERARQQEQALRKGRKVLGAPPQRDCFAKALFESRQAGKKILDRYLIGFELETGAPLWVSDDDLCTHAAVFAKTGVGKTLWLESLLFQQMLRGRASGCTFIDAKRDSGTLAHIIYMAHITGRIEDLIVIDPLSPIHSYNFVATTQRADVKARKVLRAGLPPIADASTAKHYDRLAADSVFRIVRALDSIGLSWSIKDVAVALSSFAIAYPYLHNVLQSVNAQEALLELSHFATTYRTAKGTLDIQKLTDNLRGIASELHSIAAGDAGDVFCSTHSDLRLTEAIMQGKIVYFMLPRLEESEGASRMLKVFREDLEVSIGEITSNQDFRLDDPHLVIVDEGASTFSPTWANLFELARKGRFALLFGAQSAAGLSDQSLGLSQAFYERVMANVNLKVAMRLGDNKTAMDLSHWLGKTTVIKKSVSRSKSKGSASSALLFDANAKRQTGRSSTESFYEEEVDSVSADELKYGLLAEKGLAWVDLGGKLTKMRALWIDFDLPKDWKGRSTVPQLEITETDPLALGKIVDRAVLESEIINQQRQTNVASTSIVSSVSTPTRIEASRSKHQETFKLLHNDQHRSSRYESSVVVPTHLQRQTMVGSESRPSFFRLSSKKSPRKR
>NZ_AP018205|131974:291391|210993_212283_-|WP_017291677.1|DBSCAN-SWA
MMLFKLRFYFARGLFKKNLEVQQQAAQLIAKTAEIIRAQAARQQAENANRLKDEFLAIVSHELRTPLNSILGWSQLLLDREFDPATTRRALETINRNAQAQAQLIEDILDVSRLMRGKVELSIHPIDLASFLDATVESVRPQADAKSIQLSMHLDPTIGKIEADPVRLRQIIWNLLTNSIKFTPEGGQVELQVMPANSRIELQIRDTGIGIDPTFLPHIFDHFRQADSSSTRAHGGLGLGLAIVRQLVELHNGKIEAHSQGCNQGTTFRVHLPISNWHPETIADSAPNVMAATTVEEIPSLEQLQILVVEDHTDNREMVQKVLEEAGAIVIAMCSAEAEIAALEHTQPDVIVSDIAMPGEDGYDSIRHIRASRGRDIPAIALTAYARPEDQRQALNAGFHKHLSKPINAQELVRIIAQLVERSNGCSGK
>NZ_AP018205|131974:291391|223191_224211_+|WP_017291689.1|DBSCAN-SWA
MTSTLPKVYKPLIPPVLGLGLGTLILLIILIHSVTLGARDIPLPTILASFTTFDNSFDHLVIQTVRLPRSLIALSVGAALAVSGALMQGLTRNPLAETGILGIEAGGALAVVISLFLFGSSSLTIYAGVAFLGAAIAAILVYFLGTLGRGGATPLNLTVAGAAMSALIASITTAILIVSQRTLEEIRFWLAGSLAGRDFDLFLQVLPFLSAGLVLAFLLSRQITTISLGEEVATSLGQQTLWVKFLTATSVVLLAGSSVAIAGPIGFIGLVVPHMVKFFIKTDYRWILPYSAILGAILLLVSDIAARVLLKPQELPVGVMTAIVGAPFFVYLAKSKVKK
>NZ_AP018205|131974:291391|142648_142846_-|WP_017291627.1|DBSCAN-SWA
MKQTASITILNAPDSANPPSTIATPIPTPAARRYVKDFARLAFASTQTVAPACHRPCAKSEDFGK
>NZ_AP018205|131974:291391|224207_225239_+|WP_017291690.1|DBSCAN-SWA
MSDWRSPVLSFRLDRRVPAIALLLLGIGFAAIVFNVGRGEYPIAVFDIIRTLFGIDTGNPDHAFVIQTLRLPRTLVAFMVGAALSLSGTIFQGLTRNPLADPSIIGINTGASLAAVSVIVLFPNAPVYVVPFSAFAGAALMAMLIYGLAWHGGSSPTLLILMGIGLSAIASAFTSLLITFGSIYDVSQALVWLAGSVYGRTWEQFFSFLPWLIVLVPAAFGLARHLNVLNLGEDIAKGLGSRVEWQRGLLAMVAVGLAGASVATAGTIGFVGLIAPHLGRQIVGNRHEELLPISALIGGVLVVMADFVGRTVFAPIELPCGVVTAGIGAPFFLYLLVHQRQTA
>NZ_AP018205|131974:291391|195347_199070_-|WP_017291668.1|DBSCAN-SWA
MTEALTPAATATDLTPAVSLNEAERLEALRRYDILDTPPETAFDRITSLAARLFDVPIALVSLIDESRGWFKSAYGFHLQQVDRDSTICSLALLSDKILVIPDTRQDDRLGCNPFVQSESGVRFYAGAPLITHDGFNLGTLCLLDSQPREALTDQQETTLIDLAAMVIDELELRLAARKVKQIDAALLEVTQGVSARVGSDFFTALVQHLTKTLGVDYTYIGLVSGKEQESIQTIAVCAKGQIIDNFDYWLRDTPCREVLQKRELCCYPNRVQERFPNAPLLEPLSIESYVAIPFFDATGTPLGLLGVMDTKPLADVQLAESLLAIFVLRITTELERQQTEAARQQTQQDLENLIAQRTIELSQANDQLQLEITERQQAQTLLEKEQEVLSILLDTVQAGIVACNAEGILTLFNQAAREFHGLPEQPLPPGQWAECYDLYQPDGKTLLTQDEIPLFRALQGETVQNVEMVIAPKQGTPRTLLASGQAIVDRQGQSQGAVVVMHDITERKQAEAELLISDVALQQMPDAILMTDLEGKIQRWLGNAEQIFGYTAAEAIGRPVNFLHHPNIQPTKLAEMIRIMDETGGFFGEVPCQRKDGSEVAIETTARTVYNKAGNPLFFIGINKDITERKQNEAERAELLRQQVQEQTARLEAEADQRRAAFLSEVSTVLASSLDCEHTLTQVANLVVPFFADWCSIDLVQNQSIHRIAVAHRNPAKVELGWQIHRQFPVAMDAAQGVPKVLRTGMSELVAEISDAALAAAVQNEQHLQLLHELGLKSCILSPLVARGQILGAIAFVTAESERRYGEADLALAEDISHRIAIAIENAHLYEAERTARSAAEAANRVKDEFLAVLSHELRTPLNPILGWTKILLSGKLDAAKTAHALETIERNAKLQTQLIEDLLDVSRVLQGKLSLNMTPVDLRSTIEAALETVRLAAEAKSIQLQTSFAPELGQVLGDAARLQQIVWNLLTNAVKFTPSGGTVAVRLEVVELSRSPVENSTQPSSRSQSRQRYAQIQVTDTGRGIDPNFLPHVFEYFRQADSSITRQFGGLGLGLAIVRHLVELHGGTLGVESPGEDQGATFTVRLPLIQDAGKSIKTGADLDSLSLLPHPLEDICVLVVDDEPDARELAVFILEQAGANVTVASSAIEALAVFFHSKPDVIVSDIGMPEMDGYMLLQKIRELRPAQQSPAIALTAYAGELNHQQALAAGFQQHLAKPLEPEELVKTIASLLTRRKVG
>NZ_AP018205|131974:291391|166254_172275_+|WP_017291650.1|DBSCAN-SWA
MALSLSGFTITDLLQEGTKSLIYRGVRDADGCSVVIKGLRPEVCTARNVEQLKHEYTIAQQLNLPGTVQALDLEFDRGLPYLILEDFGGRSLDQLLGQFREPAAFLNIALQIVDALAQIHQRHIVHKDIKPQNIIVNLDCNQIKIGDFGLAAFLPYESQIVSHSNRIEGSLPYLSPEQTGRMNRGIDQRSDLYALGVTFYEMLTGQLPFQGADPLEWIHCHIAKTSISPTVVNPAIPQILSEIILKLLAKVAEERYQSAIGLQADLERCLQLWETARQLSSFTIAEHDISDRLQIPQKLYGREPEITQLLTVFEQVVTTGKPELILVSGYSGVGKSSLVNELHKPIVQTQGIFISGKFDQYKRNIPYSTIVQAFQGLVRQLLTEPEEKLVIWRDRIQSAVGKNGKLITDVIPEVELIIGEQPPIPVLGAAETQNRFNLVFQNFIGAFAQSDHPLAIFLDDMQWADSATLNLIQTLITGATLRFLCFLLAYRDNEVDISHPFSLMVEKLRQQEIPLTEIVLAPLDLSCVSQLIAETLRCSLEQSEPLAQLVLHKTNGNPFFVNEFLKTLCQENLLTFNAVEKVWQWDIKQIEAKGFTDNVVNLMIEKMQKLRPKTQQLLKLASCIGNRFDLEILAIVAQQATHTVADAMREAVLRGLILGEEQTEAAEEYYSFAHDRIQQAAYALIPDAEKQLVHLQIGRLLLKHLKSEQLEDQLFDVVNHLNLGQELIIEQAEKHQLMQFNVLAGKRAKASTAYVPALRFFDTASRLLPSDAWKSDYDQVFNLFTELAECEYLTGNLERAESLFQLLLDKAQTALDQTTIYMLQIRLYQVAGRFDEAFNLGLAALRLFGVVFPETDEQVEAAVSWERQQAVENLGDRQIADLIHAPILEDPTLKTIISLLTSMGPPAYLSKPNLFPLVVLKALNYSLKFGNTEESCFAYSMYSMLLVSMFRDIPSGYAFSEMTIRLNQKLNDPKYKGTVLHIHGSHINVWCHPMTTDLPFLEQGFLGCVEAGDITMANYNGFQGSWQMLEAITPLADADRAIQKYLAFAQQSKHEAAYQTIRLQQQFILNLQGQTRHCQTLNDDEFNEAKALAILQQTEFASGIVFYHVIKLIVLFTYEQYPEALQSAQKAFGILGAVRSLPIEANYLLHHALVLAALYPHESREIQAKFLETLHQHQQQLRYWADHCSANFLHKAVLVAAEIARIEGRDLEAMRLYEQSIKSAYEYEFVQYEALAYELAAKFYLNREFEAIAKTYLQEARNAYLRWGALGKVQHLEIHYPALLPQLQPVSPKNPAASSSTTFVSSKEQLDILSVIKASQTISSEIVLADLLKTLMQIAIEQAGAEVGYILLSRHDRLVIEVEAKANQTQEQLKIQQLIADAETSLSVPQSILNYVQRTQEVVILDNAVASDLFSEDRYIIQNQPKSILCLPIVHKTKLIAILYLENNLATGAFTQTQLSALEILSAQIAISLENAQLYKDIAESQEQLNLALQSGQIGVWSWDIVNDQVEWDDQMYQAFGVSPQTFDHTLESVINCIHPDDRDNFTQALSQTLGEGVEHNLEYRVVFPDGTIHDIAARGRPFFNKMGEPILLRGIVLDITDRKRLEEQRLQLLREQTARAEAESANRIKDEFLAVLSHELRSPLNPILGWAKLLRTQKLSESKTAQALETIERNAKLQSELIEDLLDVSRILQGKLSLNTVPVNLSTMIQAAIETVQLAAEAKSIAIEVTLEPQISQVLGDSNRLQQVVWNLLSNAVKFTPAGGKVEVRLESNEGDHTEDSSSFTRYAQITVTDTGRGIHPDFLPHVFECFRQADSATTRKFSGLGLGLAIVRHLVELHGGIVQADSPGEGLGATFTVRLPLMATPLIPKGETQPSIAANLNGLQILVVDDDTDTREFVAFVLEQAGASILTAASASEAFTTLMQSQPHLLLSDIGMPDIDGYMLIRQIRALPPEQGSTIPAIALTAFAGEMNQQQALAAGFQKHLSKPIEPDRLISTIASLVVR
>NZ_AP018205|131974:291391|225331_225613_-|WP_051077907.1|DBSCAN-SWA
MSSSNCQFCRAYLRSLLEKIYGCVALANPEKRIYLLGDLSPDTDHALLQLIQMCSNHPKGGFSWKNQPQQLESTILACIPSILTFSPEKEDEE
>NZ_AP018205|131974:291391|290344_291391_-|WP_017291719.1|transposase|DBSCAN-SWA
MLPSFYQSCLKSQLSDAQFITLEILVNLLQQERRITIERLATLFPQPILFESRRRNLQRFLSLPQMTPEALWFPIAKQWIKQHIPRGQILQIVLDRTQWNRHNLMMVSFVYHNRAIPLYWTWLDKQGQSSLRDQQSVLQPVFRLLKKRRFVLLGDREFHSIELAAWCVAKNVLFIFRLPKSTTVQPEAGAGFSRLDDLPQSPGIPEQYLQIQVTQKRGFGRHNLVMYQKRAYAQSTTPEVWYLLTNLTDINQVLFHYDFRFCIEPGFKDFKSGGYHLEDCHADFHRFTALLVLMTIAYSLASVQGKRIRKKQVQQYVGRVKEPKRAHYRHSRFWIGLYGSLWIGSLNL
>NZ_AP018205|131974:291391|208185_208518_+|WP_017291675.1|DBSCAN-SWA
MPHVLLVDDEAPLRDSLSYALQKEGYEVTTAADVAAALKLFHKQVPDVILLDLMLPEVGGMEVCWRIRAFSDVPIVMLTAKDQDIDKVWGLEAGADDYITKPLELLGNKL
>NZ_AP018205|131974:291391|139177_139585_+|WP_017291624.1|DBSCAN-SWA
MDSSRRRIVVPISLQPADRARLEELRSRFATILKSNINTSETVRLAISIGSAASHEQVRQVVLQTTRIPRGRPPIPWTARYLDDQEEEWVREEQERLQRLRLIHELQVLRSYLVRTSDQEKRLEEICRELNMVLA
>NZ_AP018205|131974:291391|199124_202376_-|WP_017291669.1|DBSCAN-SWA
MLNNQTSGHDFSEQHNGQATETGSSALVSGDDRVGMVLQLADGSIQACNTVAEKFLGFTLAQMQGCHYIDCPWQTIRTDGSPFPGDSHPPMVALRTGQPVTGEVMGVYQPNGDLVWLKINAQPLFQQNNTVPWAVVTTFAPLSEIEMCDRFLSQGVPAILWINLPKGECSSANQWFYDYTGLPLGSAEGWGWTVALHPDDRDLVHQGWQRSTQQGQPFEMEYRLRRADGEYRWFLSRSSPVQDSSGRIHHWFGVAVDIHDFKCSQEDLQRREAIFRRLVEISMFGVAIGDFSGKMLYANDALLNLIGYSREELEAGQILWINLTPPEYLHLDLQAGEELRQHRVSTPFEKEYFHKDGHRVPILIGGALIDEPHTEQELIVCFYLDLSELKQTENSLQEALKRLNSHVENTPMAVIEWDANLIVRRWSGAVSQMFGWKAEEVLGTYISDLNLVYEDDTPIITEVSQRILSGTEPQIISQNRNYTKDGSILHCVWYNSTLTDATGQVASVLSLVMDITEQVQAEELLRQSEERFRLAARAVAGMVYDWNVQTGEVYRSEGVYELIGFPPEAVPQNSAWWGEKMHPEDYHQVEQHWAAIVSGQSNHYDVEYRIRHRAGHWVNVWDRGYLIRDRQGQVVRVVGSTTDITARKQIEQQREQLLRREQAAREQAELVSRMKDEFLAAISHELRTPLNPILGWTKMLQTHQFTPEKVSQALATIEHNARLQVQLIEDLLDISRIMQGKLSLNVTPVPLQSIIAAAIETVQLAADAKAIAIQTSLDPDVQPISGDAARLQQVMWNLLSNAIKFTPTGGRVEVGLSWVDADNANENATQPLWVSDDSPSTHDPAPMTQYAQIVVRDTGIGISPDFLPQVFEYFRQEDGATTRRFGGLGLGLAIVKRIVELHGGTIWAENAGMGQGATFTIQLPLRREWGDRAMRKWIDHHSTTLSPAQSLTGLQILVVDDDPDSRNYVAFLLELEQAIVTAVDSAAAALRILSQSQPDILLSDIGMPQIDGYELMQQIRYHLRISEKQLPAIALTAYAGELDHQQALAAGFQQHLTKPIEPEQLVNAIASLVGKQPDPLKPT
>NZ_AP018205|131974:291391|150405_150588_+|WP_017291637.1|DBSCAN-SWA
MHNNAIFIYVYQPCIASIFSDPKRIAGRWSDGSFIADPFLMRISAWIAFCIDFAVYLHGA
>NZ_AP018205|131974:291391|137991_138819_-|WP_017291623.1|DBSCAN-SWA
MAKQIRLAIMTGAGGVGKTTLAANLGYEIARLGYKVGLFDLDPQGSLNVACRLNKTPAPKTTCAWIFSGFFDGTYSFVPVWSNHVKTLEVLQGGNALFKVMPNLAQTGGVDLLKDAIEQYPLPHDLIIFDCPATLETIPKAALVAATHLLIPLVPDAKAIDGTRVLLDWYAASIQELKLDSPPKILGFVINNVENGAEHQRLSQELPPYYKARGYEVFPMIRHYTAFTNAWSEGVPLRVHRTSHPAIEPLEAIVNNIVKELGGKQRGKARSTRHR
>NZ_AP018205|131974:291391|147587_148607_+|WP_081614819.1|DBSCAN-SWA
MMRRFRVSALTMKEWMARLLLVGFLMGVLRHHQISNRLQQTYQNMTRWLSLTLERIPTAWFVTGAVVILALIALWVEKETSISSIRDVVQVIFKNAESIAVVAAVILYFKEIPERRAQKHYEAWQVVDAAANVSVSYARIRALEDLNRDGVSLEGIAAMNANLEGIALRGALLTEANLAGANLSAADFTDTVSMKIRLGQATLKQAKLNGSDLTAAELEGAILTQAKLMNANLTGAKFTSAQLAYADLSGSTFTGATLTGVKAVGSNFYYAKLYEANLSQGNFAEANFTEADLTGANLTGANFKGVKGLTAKAVRMANHWESAVFDPELAAQLGMASDS
>NZ_AP018205|131974:291391|157826_158720_+|WP_017291646.1|DBSCAN-SWA
MGKKNSRWLRNAQTRQNGSPSYIAQYGVAIVSVTLALGIILALNAYLASTPSPLFFAAVMLSAWYGGLDSGIPATVFPTLVINFFLVEPIYELGMPDLGTFARLGPFVMTALFINSLTEAQRAARHKAEIKFKSLQESEAQFGCLAGSNIIRTLVARIDGVILDANQNFLQLVGSSQEELHTGRLDWRMITPPESVGGSERAVAQLLLTGGCTPLEKEYPRKDGFRVPVLHGAVMTGDVTVTDFVLDLSEHKRVTAIQQEAMRREHLLLAPQRAANAQLETVLASINDQFLVLVLQL
>NZ_AP018205|131974:291391|159941_162389_+|WP_081614820.1|DBSCAN-SWA
MDSATLERTPASVVWLRLVRTDTRLAQSVHRIHAAMSAPQSSFVAMHLDDSASTTSPKMFTTFLGFPISTTVVLDQQSRYVYVNDRVIKVVGRSKEELIGQCIWDLFPDLVDSQFYTKVHRAAAEQRNLQFEYFYAPWHRWFENHIYPSTTGVPILVTDITERKRAEEELQCTNQTLQTLLDFCPVAIAFFDSERTIKLWNRAAEQIFGWSAEETVGINWPTVPHRQAEFLASLQTVLSGQSLNGYEAQHKRKNGQRVDLEIWANLTHDAEGSPGCLGIALDITERKQAEAALRHSEDRFQVLVSNMPGMVYRYAPCANGNAASTKAKFTYVSSGSRALVELEPEAILQDANDFLQLIHPDDKSSFQNSADVAVQNSAPWRWEGRLITPSGQHKWVQGRSRPQYTEQREVWDRLFFDITDHKRAEAERLQLLEQEREAREQAEAANQIKDEFLAVLSHELRTPLNPILGWSRLLRQGILDNSRTTTALETIERNAKLQIQLIDDLLDISRILQGKLSLKSVPVELNATIATAIETVRLAAEAKAISIQIQFECKAMTVLGDSGRLQQVTWNLLTNSVKFTPATGQIQIRLSTTQFQAQIQVTDTGKGIHPDFLPHVFEYFRQADSTTTRTFGGLGLGLAIVRHLVELHGGQIRAESSGEGQGATFTVTLPRMPSSPSILEEALPMSDLNLQGANVLVVDDEVDNLELVQFILEQAGATIIAASLATEALDQVRQLKPHLIVADIGMPEVDGYTLIQQVRKLLPEEGEQIPAIALAAYASEVNQQQALAVGFQRHLAKPVDPDALVQAISELLHQT
>NZ_AP018205|131974:291391|281495_282257_-|WP_017291710.1|DBSCAN-SWA
MTSSVTEQLKAMRLVGMLDAWMEQRNSPTYHDLSFEDRFTLLLEREQLHRSQMRLQRRLRQAQLSTTAHLSDIDFTVPRGLSKTKFLELAGGKWVQDHLNLIIVGATGVGKTFLSSVLADQFCTLGHSVRYFKCADLLMELKFAKADGSFRRFQQQIAAFELIILDDWLRDAVSSDQARDLLDLLDVRYRTASCLFATQLPVNQWHSQIQDPTLADAMLDRIVHDSIRLVLKGESMRKLTSKVNVNSDSIDAE
>NZ_AP018205|131974:291391|218195_218465_+|WP_017291684.1|DBSCAN-SWA
MNSVRLLLAYSDRECTIAQRPFPRYRGLYVSRFRYYPLDAFDDGFPDSVCFTNSGTEKVTGLSVKVGERVFQLENKNGLFLISSEIANI
>NZ_AP018205|131974:291391|194711_195260_-|WP_017291667.1|DBSCAN-SWA
MLLALSQSLFRRRLTRAIALPIVLLLLLSGMSIWQITRLLSALRWVDHTNQVISQANTTQKLLLDMETGLRGYLLTGRQDFLEPYEQANAEIDANLSQLRNLVSDNPSQVQRVDQLVVDSQQWKQQVLTALDRKQRGESEPFSALDRRKQSSDRIRQQLARFIATEEQLLFPRDAQGVHHER
>NZ_AP018205|131974:291391|216124_218050_+|WP_017291683.1|DBSCAN-SWA
MLQSESLQDQIERNPVEIAQQDSDPSSEEEEIIGVEKLQKPTSTPVYTIDSDEIRRESADSLAEILRRLPGFAVNDAGFGADIHTGTFYRGASINQSVFLLNGRPIGTNVNIYHGGTDLSSIPTGAIERVELTSGTAATLYGSEAIGGVVNVVTKKGTGIPQFNGFAQLGSFSTSNYRGSYSGALGAVNYLFSYQRFKADNDYFVPVGAANRGPDGRLFNGDSTQDNYYGNLSFDLNDRNSLSLDVSTVTSRRGLLYFGFPLQRDRLDHDTVNVGLTWKAALGRGDDSTLNTTLSFNQDYFSTYGPTQTTFFRRGIVNSRGFNARVEHNWQTSKTNNLRWGVDLQNSLLNGEAFSTLPQLAQFNGGFDRDRFQTALFALNTWQITNSFQAEFGLRQNFTSEFGSYLNPSVGTRWAVSPNLALRGSWVSVHRNPGLDQLYAFDTVHNWLPNPNLKPETGSSWTAGIDVQLSQSFAAQFTYFGSRLNDRIAVQSGQWANIGLVNTNGIEAALRWQIAPQWSTFVNYTYTDARIGSGVEQGLQLSTIPFSVARFGIGYASNGWEVNLFANYFSGARRALFTLASDSSRDFSPAWISFDLGLRIPIARGLGLSVFLENLADHSYEKVNRIYQPGLTYRIGLVSDF
>NZ_AP018205|131974:291391|236288_241076_+|WP_017291696.1|DBSCAN-SWA
MSNVINAIEGIAIVGMSGRFPGAKTVDAFWQNLRSGIESIAFFTDEELIAAGIDPVVVRDSNYVKASALLDGIEQFDAAFFGFNPKEAAMMDPQQRIFLECAWEALENAGYDCQRCGDRMGVYAGVGLNQYWVFQIAPDRQLLESAAGYQTVIGNEKDFLTTRVSYQLNLKGPSLDIQTACSTSLVATSLACQSLLSYQCDMALAGGITIHALQKSGYFYQEGGILSPDGHCRAFDAKAQGTVPGSGVGIVVLKRLEDALADGDCILAVIKSSAINNDGSMKVGYTAPSVEGQAEVIAEALALAGIEADSISYVEAHGTGTALGDPIELAALTKAFRDSTERRNFCAIGSVKTNIGHLDAAAGVTGLIKTVLALKHQQIPPSLYFEQPNPQIDFANTPFYVNTTLTDWQTHHQPRRAAVSSLGIGGTNAHIILEEAPAIASSSASRSHQLLLLSAKTASALKTATTNLANHLQQNSDCNLADVAYTLQTGRKRFEHRCMVVVRDREDAIESLSSLDPQRNFIQSAGGERPIAFMFPGQGSQYVNMGRELYETEAIFREQVDRCCELLKSHLGLDLRSLLYPDVETVETAQRLQQTAIAQPALFVIEYALAQLWLNWGIRPQALIGHSIGEYVAACIAGVFSLKDALALVSARAQLMQQLPTGAMLAVPLSEHDLQPLLGRDLSLATINSVTQCVVSGSEAAIVTLQHQLSEQGIESRLLHTSHAFHSQMMEAIVEPFIQRVKTIPLHSPQIPYISNVTGTWITADQATNPAYWGNHLRQTVRFADGIDQLWQDSQRILLEVGPGRTLSTFAQRHSAKTAAHIILTSLRHPQKQRSDVALLLQTLGQLWQCGVSVDWSTFYAHERRYRLPLPTYPFERQRYWIEPRSFLQPSTTSNRWDELIQAAQQQANQGISALAVDPSQAPKVLSALMENDPPKPNLLDRIGKKLEMADWFYLPSWKRSLPPAPVQTLASKCWLVFVDEWGLGEKLAQRLNQSGQTVVMVRAGTQFQRLHSLVEQNSVNCHYTIAPHRPGDYRTLLDDLRTLGKQPEAIAHLWSVTNETNSSLESLEQTETLSFFSLLFLAQALSEQSSDCAIDINIISNQVQDIAGSEELCPSKALSLGPCKVIPQEYPNFTCRSIDVVLPVHNQDEKLIQQLFVELTTPSSDQTIAYRGNHRWVQTFEAVRWDNTRSSRLRDQGVYLITGGLGGLGLTIAEYLAQTVQAKLVLVGRSPFPAREEWAQWLATHDRQDETSLKIEKLQALERLGAEVLPLSADVSNSTQMQAVLTRINEQFGQLHGVIHAAGVTPGGMMQTKTAEAAARILTPKVKGTLVLADLLKNTPLDFLVLCSSLTAILGGLGMVDHCAANAFLDAFAYHHQIQYPDRLTVSVNWDSWQEVGQAANTIIPATLKQVREENLKQGILPQEGIEAFCRILQCMVPQVLVSTRDFQMQLQYDHLLNSVEHLEPVRQDLHPRPALSNAYIAPSSAIEQTVAEIWQESLGIESIGIQDNFFHLGGDSLLAVQIVSRLRDAFSVELSLQTLLSDAPTIAELSKTIRTLQAETNELDVMNELLLEIESLSLSEIQEQLEAAQFSNH
>NZ_AP018205|131974:291391|158898_160098_-|WP_017286974.1|transposase|DBSCAN-SWA
MLSHPGALLQMRTEVQTWLREFDALIARVGYQFGRVEARQRMQEYVQGLLSPIERKNGWQLSEQCGDETPYGIQHLLNRSKWSADELRDDVRSYVVEQMGDREAVLVIDETGFLKKGKHSVGVQRQYSGTAGRVENCQIGVFLVYATRQGHTFLDRELYLPKSWTDDAARCRAAHIPVERKFATKPKLARMMLERTFEAQVPVGWVTGDSVYGSDYHLRDLLEQHQVRYVLEVACDHSVSFKWEKQRIDQVIAELDSSDWSRLSAGSGAKGQRWFDWTAIAIPHPERPNWQRWVVARRSVDQPNEVAYFLAFVPTETPLEAVVKIAGTRWTIEMCFQTAKGEVGFDQYEVRTWQGWYRHITLSCLAHAFLTIVRSHASELEKGGHLSRQFSAFKRKRGL
>NZ_AP018205|131974:291391|269219_273200_+|WP_017291703.1|DBSCAN-SWA
MQLQDRVIQGFRLSPQQKRLWEVQQENGIYRVQCTVRIDGDLNLGVLKSALQQIIDRHEILRTDFVRPGGLKTPIQVIAESGQLVWHKIDLRGGSVQQQQTHINALFEQDRCQAFDVEHGSGLRSTLLTLSAQQHILLLSLPALCADARTLKNLVQEVGQSYQACLRGETLDDEIVQYTQFSEWQNQFLEDEDAHIGHTYWQQQDFSRITTLKLPFKAKSIRSAPFDVRALEQQIAPETIAKINALTQQHNTTPATFFLACWMILLWRFTQQGEIIVGTACEGRNDEELETAIGLFAKYLPLRCCLQEQETFDQLLRSIDQTVQNHLQWQDYFTGNHLEQQSERGWKALPFCFDFDDQPAVYAADGLVFTLERHSPYTERFKLNLSCTQTAEALFTRFHYDATLFSDEDIQQLGEHWQVLIEGIVANPQKTIAQLPILSDRQRHQLLVEFNNTQTPVSKFCMHKRFEAQVDRTPNQIAVIFEDQQLTYAELNTRAAQLACDLQALGVKPEVRVGICLERSCDFIIAMLAVLKAGGAYVPLDPAFPRERLAFMMQDAQISVLLTQTLLLKSIPDITAPVICLDNRPDFSDSPLLSHRPTPSNLAYVIYTSGSTGKPKGVAVEHQQLCNYVQGILERLNLPEGSSFATVSTIAADLGNTAIFSALCTGGCLHIISADRATTPQAFADYCRYHAIDCLKIVPSHLEALLASGNADILPRQRLILGGEACNWSLIETIQQLAPNCVILNHYGPTETTIGVLTYQVEDLPTHARTNSVLLGRPIANTQAYVLDQQLQPVPIGIPGELYISGDNLARGYLNQPQLTAERFIHHPFSQDGRLYKTGDLVRYRTDGNLEFLGRMDDQVKIRGFRVELGEIETALCQHPDIQQAIVLLRSDVAGNPRLIAYVISHSQATSTTHDWRNFLKAQMPEYMLPSAFIRLKTLPLTPNGKIDKQALPIPDLFKSDQETTFVPPREALELQLTQIWEDLLNVRPISVTDNFFDLGGHSLLAVRLIAQIEKQFQHKLPLSSFLQAATIEHLAGILRQQPQAWERSPLIKIQSHGTNSPLFFMHPIGGNVICYASLASHLGSEQPFYGVEAPGLYGEEVPLESVEALAAHYIQALKTIQPQGPYYLGGWSMGGIVAFEMAQQLQQQGEAIALLALLDSTPPLSNTPSPTDNTNSLEDARLLADLAESTAHFFGKQLSISPTELQSLDPEQQLNYVLEVMKAANFVPPDIQPSQIQAFLQVYKSNARALMRYVPKRYSGQITLFRSSQPLPEHQTISDTISSWASLSTQPIDIHTVPGDHTTMLAEPNVQVLAAQIKDCLKRTA
>NZ_AP018205|131974:291391|279611_281258_-|WP_026149073.1|transposase|DBSCAN-SWA
MELLTQLLPNPEHLQLQNYELDVEQRQIRVLMESVQQIVRCPVCDQVAHRVHSLYERTLADLPWADYQIVIQLTVGKFFCDQERCDRKIFTERIAGVMAPWARRTKRLAAQLSEIALYTGGEGGAKLSKTLHCEVSQNTLLSLISRQSIPAVKTPKALGVDDFAFRRGQRYGTILVDLETNRPIVLLPDREADTLAEWLKEHPGVEVLSRDRSKTYRQGMTRGAPNATQVADRFHLLKNLAEVLERILAMHTQQLKAVEAAQIPVNDAIMIAPVVPRLAIQERSAKARERRFAKYEQVHQLRQQGWEILEIARHLGMGKRTVYRYLSHSKFPEWQPHPHRGRSQRSQLDAYKPYVLNQWNQGQSNTKQLFEEIQQQGYRGSYQTVARYTHRLRQTQKQHRAQLGVQLQLPISDLQHPPLTARRATWMVMRRADQRTDVEQVLIADLKTQHPELAAAIDLTQGFTKLVRERLPQQLDIWLDQAMSSSMKLFQGFAQGLKEDYAAVKASLMTDISNGPVEGNINRLKLLKRQMYGRASFDLLNRRFILTS
>NZ_AP018205|131974:291391|178672_180136_+|WP_086371084.1|DBSCAN-SWA
MIGITKRFGGVIANDAIDFRVRTGEIHALLGENGAGKTTLMNILCGLFEPDQGEIRVQGKPVKFHSARDAIACGIGMVHQHFKLVESFTVAENIVLGQSSSVLQASAKQLYPRLQRLADDYGLKVNPPAQIWQLSVGEQQRVEILKALYREANILIFDEPTAVLTPQEAQDLMVILRNLAAQGTSIVFISHKLNEVMAVCDRVTVLRDGQAVATIATQDCTEHQLAQLMVGRDINSTQKLPRSTSSTPGLALKNLWVMSDRGFPALKGIDLAIEQGEIVGIVGVDGNGQRELEEAIIGLRLLKQGEIWMSGNLAHIPSDRYSMGLLTDFSIAENLVLKDVQSPSFQQKGLLHWRLIFNYATDLVQRFLIRASSVKMQVGKLSGGNAQKVVFARELSRDHQVLLAAQPTRGLDIGATEFVHAQLLARREAGVAVLLISTELDEILKLSDRIAVLYEGEIIAVIDDKNVNLHDLGLLMAGKKGGNFAES
>NZ_AP018205|131974:291391|145440_146570_-|WP_096735604.1|transposase|DBSCAN-SWA
MSNQAKKYSPQFKAKVVLELLRGEKTQTEISRAHGVHRSVLTRWQNEFVERASSVFGEVGQVSEVESRIAELEQMVGKLTMQLEIAKKASSNLSDETKRQIVAELEPHYSVRQICEVLSVNRSSLYYQPVEEELATETELKSAIDKIAGEFPRYGYRRITQQLKRQGIVVNHKRVARMMKEMGIAGKAPKRRCRTTNSNHSFARYPNRVAGLKIERPNQVWVSDITYIRLGEGFVYLAVLMDVFTRCIRGWHLGRGLDHSLTLTALNKALEHYQPEIHHSDQGVQYAATGYVEVLKQRKIEISMAEVGEPTQNGYAERLMRTIKEEEVDLSEYRNFAEVYMQVKVFLEEVYMRKRIHSSIGYLTPIEFESEWRSNQ
>NZ_AP018205|131974:291391|282272_283823_-|WP_017291711.1|transposase|DBSCAN-SWA
MSKRTGQGAGLSMDKFREIMRLHELGHSQCSIAQSCAVARSTVQDYIRRATAKGLSYEQIQQLSDSEAKAQLGKGKRAVKEKLETIDFTTLEIELQRKGVTLALLWQEGIDKQQWDCSYGTFCRRYNKWKVRHQLTMRQVYKAGEKLFVDYCGPTVEVMHPETQTVTQAQIFVACFGASNYTYAEATPSQELPHWIGAHQRALPFFGGVPECIVPDNLKSGVTDPCRYEPGINRSYEEFARHFNVVILPARPNKPKDKAKVEKAVQEVERQILAPLRHERFTNFTDLNAAILVPLQHLNDRVMSGYGVSRQVLFEQVDKPALKALPSHPFTFARWRTAKVNLDYHLEVEKHYYSVPYWYVQREVQVKIAEHLIEVFHDHQRIAVHERSRVQYRHSTVAEHMPPEHWEYKRQSKERFLAWADQIGSHTRAQVEAIFNTKAHEEQAFRSIRGIQRLATTHGTQRLEAACRRANAFGMVGLRRLRSILATRLDTATVEAEPVATSAIEHPNLRGAQYYH
>NZ_AP018205|131974:291391|225940_226471_-|WP_017291691.1|DBSCAN-SWA
MTQMLVRPFGQVADNVILLDRSTTEPVCEGLNIALASFQALYLQYQKHHFVVEGAEFYSLHQFFEEGYEAVQGHVHDIGERLNGLGGVPVASFAKLAELCCFTPEPDGEFRCRQMVENDLAAEQALISLLRRLASQTESLGDRATRHLLETILLKTEERAYHLAHFLAPDTLVVLN
>NZ_AP018205|131974:291391|154538_154829_+|WP_017291642.1|DBSCAN-SWA
MLSISGVLGPLTIKITQLPNVTVVENDWRSFTIDIGSAIVSVTVRPRIWNNWVEGTKQYQNWSAIITGRMGELTDVGFVLEQPGIQIFEAPSEPVD
>NZ_AP018205|131974:291391|202430_205298_-|WP_017291670.1|DBSCAN-SWA
MVTRTITAKLQRFFPAQFDLEIQASVWRYSIALLAVAAALSITLLLDPLLRGTPAALFFVAVMISSWLGGFGAGLFATLLSTVALNYFFLEPLYSLDLANLRAVFQLSVFAIAAILISSLNEAQRSAKKRADANLKAWRDSEAQFAHLSEANIIGIFQADRNGSITEANDTFLQMLGYTREDLLSGRIRWNEIVPPEYQEATQRSEWNQCSHAQQERCTTDVCTPFETEYIRKDGARVPMLLGSVTRDEQTVIGFVLDRGEFKRNEAERQQAEAALREREQRLDLATSAANLGVFEWNIQTDYAVWENARMYEIFGRTLAEGTLNKVEFINNVIHPEDREAFELKLAESMMQNSSFQGVCRIRRHDKGQWCWAEFSGQFDLAPDGTPLRLIGVIGDISDRKQAEAEREQLLHRLETSLGQLEAVINHMAEGLVVADPQGNILTFNPAALAIHGYDSLEQVQRHLHKFPETIEVHDLQGSFVPMEQWPIARALQGETFSNCEIQAHRRDIGRTFIGNYGGTPVRDKQGQVILAIVTLRDVTQQRHAQAELARSLVAEQTAREEAERANRIKDEFLAVLSHELRSPLNPILGWTKLMQSQKFSPERAAQALATIERNAKLQAQLIEDLLDVSRILQGKMVLNISSVNLATTIEAAIETVHLAAEAKNIEIHTALNDNESVVSGDAARLQQIVWNLLTNAVKFTPQGGRVEVRLDHCDRFAQIQVQDTGKGISPDFLPYVFDYFRQEDGATTRKFGGLGLGLALVQHLTEQHGGTVRAESAGEGQGATFTVRLPLQSFPSATDLERFPTTSTADLHNVNILVVDDEADTRDLMLTILEAQGAQVKVVASATEALTILAQWQPDVLISDIGMPEIDGYMLMRQVRLFEASQRELPSAQPGGRIPAISAKRNCVAIALTAYAGELDQQQALSAGFQQHLAKPIEPDKLIEAIVNLLDRLR
>NZ_AP018205|131974:291391|259208_260270_+|WP_017291700.1|DBSCAN-SWA
MTQQNRAKLSLNTLGTTSRKSVKVSQSALIQTSHLLGTSIPLVIQPTVESMDLIAWATSNRETIEALFLQHRALLFRGFKIKSAEQFNQFVQATAQGELLSYRDRSSPRHEVEGKIYTSTDYPAQERIFLHNEGTYWLTYPLKIYFCCLTVAEQGGETPIADTQKVLQRLAPQIRDRFTEKKVLYVRNYNDGFGLTWQTVFQTDDKAVVEDYCRRNAIEFEWKPGDRLRTRQVRDAIAKHPITGELTWFNHAAFFHISTLEPTIRHALLTEFKEEELPQNTYYGDGSEIEPEVLDAIREAYHQETIIFPWQAGDILLLNNMLVAHGRRPYSGARKVLVGMAEPYCHREFNVEE
>NZ_AP018205|131974:291391|142898_143360_+|WP_017291628.1|DBSCAN-SWA
MVQGAGAETAIAAKLIPLVQQRWKFKFNQPVPRYGDVNVFAISPNGNLYPIKVKAIKGKVHCEGGRLFVLPNSIRERSFGGRNLLLQCRGQAEAIRVQYRIRNVYLILCFANAVMDLKVSSIDGVEIVTGADVVERLQLLDRQLNMMNSTPYC
>NZ_AP018205|131974:291391|245894_253718_+|WP_017291698.1|DBSCAN-SWA
MSAKNIEDLYRLSPMQQGMLFHSLYAPESGVYVEQVSAELQGDLNIPAFEQAWQQVLDRHPILRSAFVWENVEKPLQVVGRQVHLPLMVHDWQKLTVADQQAKLEALRQAERMQGFELSKAPLMRLILIQQAAQQYHFLWSHHHLLLDGWSTSLVLQEVFVVYEATCQGQTLRLPKPRPYRDYIGWLQQQSLPEAETFWRQTLKGFTAPTPFGVDVDHSTSAIQVGEYHTSLASETTTALQSLARQHQLTLNTLVQGAWALLLSRYSGESDVVFGTTVSGRPTTLPGAEAMVGLFINTLPVRVQVQSDRSLLPWLQQFQSQQAEARQYEYTPLFQIQQWSEIPPNSPLFESLVVFENYPIDPNVEQGNADLIVSRVQVFEQTNYPLTVIVRPGAALEISLVYDRHRFDADTIARMAGHLQTLLEGMAATLDRSLWELPLLTAAEQHQLLVEWNHPQGTDLVTHSQTACLHHLFEAQVERTPNAIALVYEDQQLTYRELNDRANQLAHYLQSLGVTPDVLVGICLERSLEMVVALLAVLKAGGAYLPLDPSYPPERLAFMIEDAQVPVLLTMAGQQNQFSTPAAKVVDLDRDAAILSQQSIENPVGEVTPDHLAYVIYTSGSTGKPKGVLIHHANVVRLFAATQPWYHFNEQDVWTLFHSYAFDFSVWEIWGALLHGGRLVVVPYWTSRSPEAFYDLLCQERVTVLNQTPSAFRQLIQVEDSLRRPSTLCLRLVIFGGEALSYQSLQPWFERHGDRSPQLVNMYGITETTVHVTYHPLTMATLGETRSVIGKPIPDLQVYLLDHHHQPVPVGVPGEMYIGGAGLARGYLNRPELTAERFIPHPFDDAPNARLYKSGDLARYLPNGEIEYLGRIDHQVKLRGFRIELGEIEALLCQYPQVNQAVVIDREDVPGDQRLVAYIVPDSTLNDAQLIDLRHFLQTKLPDYMVPAAFVVLDALPLTVNGKLDRRALPVPNDSALASDDRTTAPRTPVEEMVMGIWAKVLGLNQVGLHDNFFELGGHSLLATQVTSQVRAVFQVELPLRCLFEAPTLSAFAREIEFAIGTDRSLQAPTIDRVSRSEPLPLSFAQQRLWFLQQLDPNDTSYTLPAAVRLQGRLNIAALAQSLSAIVQRHEILRSQFVTIAGQPTQVILPEATVPLIPIDLQSLSPSEQDAEVQRLALQATQQPFDLSQAPLLRSTLLQLAENDFVLLLTMHHIVSDGWSIGVFIQEMVQLYTAFAEEQASPLAALPIQYADFALWQRQWLQGEVLDAQLAYWKQQLAGDLPILELPSDRPRPAVQSFRGATRSFQLPRDLSTALQAFSQQQGATLFMTLLAAFKTLLYRYTQQADILVGSPIANRNRAELEGLMGCFVNTLVFRTNLSGNPSFQTVLKRVREVALGAYTHQDVPFEKLVDELQPDRDLSHHPLFQVMFVLQNAPMPALELPDLTLSTLDIDSGTASFDLTLSLMETPTGLSGSCEYNTDLFEPETIARMLEQFQTLLESMIANPKQSISDLQLLPESELHQLQDWGTGEIVSNASSPLCLHQLFEAQVEQTPDAIALQWNDQHLSYRELNDRANQLASHLQSLGVAPEVLVGICVDRAPEMVIGILGILKAGGAYVPIDPGYPQDRIAFMLEDAQVSILLTQAHLLDTLPACPATTICLDTLDTIAVPLALSSLASPTSLAYVIYTSGSTGKPKGVLVEHQAICNRLLWGQTVYQLNGRDRVLQKASFGFDVSIWEIFGALIAGATLVLAPADVPQDSAALVQFIAQHQITVVDFVPSLLQVFLQMEGLETACRSLRYITCGGEAVSAQLQAQCFARLPHVELHNLYGPTEAAIDATWEVCQPTDQQTVSIGRPIANTQIYLLDANLKPVPIGVPGELYIGGFGLARGYLNRPELTAERFIPNPFWGDRDQSSARLYKTGDLARWRSDGKIEFLGRIDHQVKIRGFRVELGEVEAALEQHPEIQQAIAVIREDAPNRKQLVAYVVATLPDAALGSLRSFLKNKLPDYMLPAAFVQLESLPLTPNGKVDRRHLPAPDRTHLATKTPLVTASHAIEQRLTEIWQQVLGVESIGIHDNFFELGGDSILSIQVVARANQEGLRMTPKQLFQHQTIAELAQVVDTEQAVQAEQDAVSGELPLTPIQHWFFEQALVNPHHYNQATLLEVPATLEGSQVQQIVQQLLIHHDALRLRFEQTELGIRQVNALPEETVPFVQVDLSAIPESEQAEAITQHCEELQASLDLTSGSLVRVALFKLGANKPGRLLILIHHLAVDGVSWRILLDDFQTAYAQLQQGQAIQLPAKTTSFQHWSQRLTDYGQSVAVQQELEYWLAAHQLPSFSLPIDDPKGINTIASANTITVTLTAAETQTLLKTVPAIYRTQINDLLLSALGQTFTQWTGHPLRVDLEGHGREQLFSDVDLSRTVGWFTSIFPVYLDLSNADGMEDALRTVKEQLRRIPNQGIGCGVLRYLAPAEIAAQLRDLPQAEVCFNYLGQFDTALDATTTFKLAKESSGAVHCPEGIRPYLLEIDGFIAAQQLHLEWSYSSAIHHPATIAQLAEGFIEALRSIIARCHSPEAGSYTPSDFEAAKISQKDFDKLLAKLSQTGRHSS
>NZ_AP018205|131974:291391|241121_245888_+|WP_017291697.1|DBSCAN-SWA
MNTLSQRLAALSPEQQRLLELRLKQKGLTAPKAQSVIQPRQNQDSLPLSFAQERLWVLDQLQPEVPFYNEVHFFHLRGALNVAALEQGFNAISQRHTVLRSRFATVEGRPVQQVEPFQPFPLPIVDLSQAAETERESVARAIATQEAQQPFDLANDVLVRIKLLRLTPTHHILLLTVHHIVCDGWSVGVFIQELVRFYTAFATGEPLSLANLPIQYADFAAWQREWLQGEVLETQLAYWKQQLGGTLPVLELPTTRPRPTTETGRGAIQTSSLSPALTQALKTLSQQTGVTLFMTLLAAFNTLLYRHTRIEDILVGSPIATRNRVELEGLIGLFLNTLVFRTDVSGNPTFQELLNRVRDVALGAYAHQDVPFEKLVEELHPDRNLSQSPLFQVMFILQNTPKPALELPGLTIEPWDIDNGAATFDLTLSLQETSQGLSVSWEYNTDLFDADAIARMQGHWQTLLEGIVKNPQARLSELPLLTTQELEQLWTWGTGEHESHALVGTPQHLCIHELFEAQVEQTPDAIAVVFEDQHLTYTELNHKANQLAHQLRSWGIQPEMLVGICMETSLEMMVSIFAILKAGGAYLPLDPAYPTERLAFMLNDAKVSVLLTQTHLLNTLPQHPAQVLCVDRDQSISTAASLSPAPTGSNLAYVIYTSGSTDTPKGVMVTHRSLVNAYFAWESAYQLRAAVTCHLQMASFSFDVFSGNWIRALCSGAKLVLCPRDFLLMPDQLYSLMRREQVDCAEFVPAVLRNLLRYLETTGQSLDFMRLLMVGSDSWYVQEHQAIQRLCGTQTRLINSYGVTEATIDTTYFERTETKLSVDNLVPIGRPFPNSQVYVLDIDRQPVPIGVPGELYIGGAGVARGYLNRPELTEERFIPYVDPFTPSITTRLYRAGDLVRYLPDGNLEFLGRIDNQVKLRGFRIELGEIEATLGRSPTVAETVVVVREDEPGHKRLVAYVVPVQSTSFSLSDLRNFVKDRLPGHMVPSAFVVLEFLPLTPNGKIDRRSLPVPEIARPNLEHTYIAPQNPVETALVGIWAEILGVAQVGIDDNFFELGGDSILSIQVVAKANQQGLRMTPKQVFQYQTIAELATVVELVDAQTIAPAEQGAVTGDLPLTPIQHWFFQQELLEPHHWNQSILLEVRQAIDARLLEKAVQHLLTHHDALRLRFSRTAEGWQQQMISPDTAVPFSQVNLSNLSTAEQAIAIEQAATQLQASLNLSDGSIVRVAWFDLGLHRASRLLIVIHHLAVDGVSWRVLLEDLQTIYQQLRDVQPIKLPAKTTSFKRWAEQLVNYAQSESLQQEQSFWLTQLQKPIPPLPVDFPGGTNTVAQARTVTVTLNSAETQTLLQDVPAAYSTQINDVLLTALVQAFAAWTGKPSLLVELEGHGREDMIEGVDVSRTVGWFTAVFPVLLELDSRVDSAQALKAVKEQLRQIPNRGVGYGLLRYLNSGEIAESLRKLPQAEVSFNYLGQFDRSFAASSLFGLAQESSGSCHGLQDRRSHLFEIDGMITDGQLQMVWTYSEALHHPATVEGLAQRFLEKLRSLICHCQSPDAKGYTPSDFPLAELSQDELDAVFATVEFSVEFSGR
>NZ_AP018205|131974:291391|136832_138023_-|WP_017291622.1|DBSCAN-SWA
MAKRDRLDIDNFFSEVDQNQELHNLRGKVQSLEEELSQNVEREQQLVSEIEHLRSQMLDPKEQAQLETQIGVLRDHLKGTQGVVKYPVNKVHRNPNQPRQTFDEEVEAMRLSLLKEGQLDPIILFEDGMLFDGECRWRSAEAMGWETIDAVFTARPQDDKTLRRRAYLTSLHRRGLNALDKAETLVAIASDEIPDLPQEDVSRIVNRVLIRLKRKNQSLGDRLHLQPQEEQQRVLEELGLEEIEVQTFLVFLGLQEHPASLNRNIFPTLNLFDDLKAAIRTQRLGCPQALLLNGLSAQKLGITEKQALKLRQKAIKEVTSRNLSTIETRRWVAEQRKQSSKSGEAEDSSGEHRNEQVDQVIHVIRDLSLKDALPVEQRNELKTVLKNVLAQLEKMV
>NZ_AP018205|131974:291391|132974_133490_-|WP_017291618.1|DBSCAN-SWA
MGKRATVLDVNYNPVGSRLQRVISPLSDLDQSLTVPQDSEPLDQSKPTELDEGAGNSQSSLTAMARSQPKAGERREIMSSEIRVRCTNSERKKWQDFAYRLTGEPNTFSHIFRALLVLLEHAEEDFGRMSELVRLLTKPPKNDPLQVALFEHKIAQILWESMRRSGRVERK
>NZ_AP018205|131974:291391|190796_192959_-|WP_017291662.1|DBSCAN-SWA
MNPKREAHNRRSEKIDDLHLDRLAVVYVRQSTLQQVLEHQESTRLQYGLVDRAEALGWQRERVLVIDEDLGKSGTTAVGRSGFQRLVAEVSLNHVGLILGIEMSRLARCSKDWHQLLEVCALFRTLIGDLDGIYDPSQYNDRLLLGLKGTMSEAELHVLKTRLLEGKLNKARRGELPFDPPIGYLRRPSGEVIFDPDEQAQQVVHLIFRKFEEIGTLNGVLRYLVRADIQIPVRIREGINRGDLEWRKPNRMTLQNLLKNPAYTGAYAYGRRQQDPRKQQPGRPKTGRVVNAPEDWHALVFDQFPAYISWEQYQQNLARLAANQSRAETIGAARHGAALLSGLLVCQYCGCRMTVHYSGQGKTHEYLCNRRLKDYADRGCQHIAGRSLDVAITQQVLQALEPAALELSLQAAQSIEQERTELDKLWQQKLERANIEAERSGRHYRQVEPENRLVARQLGKEWEAKLATVEQVQEDYQRFLAQEPLTLSEVERSAIRQLAQDIPTLWNANTTTNAHRKEIMRQLINRIVVEAQGQSEQVKLVIEWLGGFQSEQIVVRPVASFEQLSYYPQLCQQVQAFVVQGLDAAAIAAQLNQSGFRPPRLQGGFSHQSTLELLRRLGLHQRRPKGYNKEPLADGEWWIPGLARQIGIPDGTLYQWVKRGWIEGRKQEKPPYRWIIRADEAEIERLNKCRQMSFSDRMRQQWQGETSVLAQSNESDDERT
>NZ_AP018205|131974:291391|139767_140670_+|WP_017291625.1|DBSCAN-SWA
MKAENDAVAINLVEDVDTKQNVQLIPLNCIQVGKQSRTYFSPHSLNLLAQSFQRYGFQGVINVRYIDRDCYEVVAGERRLRAAKLAGLKAVQCIVGDFTPEEALEFALRENLQREDLSKLEETEALLALLSLKLKLEQSHIIEVINKEGHLDRQKNNQPKSTELQQIESLLGSFGIELQTFRTKNLRTLTLPYEIRQAHLEGGLPYSSALEIGKVKDPTVRANVLQEALAQGYSVRDVQSIVQQVAQPSSRETLKPSDRVHAIARRLKKVEASIRDRVKLDQVIDQFIDVLEEIVKDRAS
>NZ_AP018205|131974:291391|288501_289107_-|WP_017291717.1|DBSCAN-SWA
MPKNPDPKCKLCSALSDTEAKQIHDAAQGGDGCWAGDPCHKLRYYYANQETINAQRRENYKRKKLAKQQVGIKHLRAQGNDFSTSDLLRAWIPQAAPVLPPERVYVQLLWYRETPKDRLHAIGALLLLGDQTIAFSGPYHCRGLAPKDVTDYLIPSMVRALNQVLNENFPEYQTYRIGRLHDEGDERHPALCPLCTGRPMR
>NZ_AP018205|131974:291391|208549_209449_-|WP_017291676.1|transposase|DBSCAN-SWA
MLNLERALNQDRLLRALTGLNRKAFDALLPSFEQAYEASRSAAKPVRKRAKGGGRKARLNSTEAKLFYILFYFKCYPTFDLAGILFDLDRSQTHEWMHELQPILETALGHELVLPERKLRSIDAFMEMFPGVERVMIDGTERPIQRPQDAEQQTQNYSGKKRRHTRKHLAAVDQTKRVLVLSKACEGKLHDKRFEAQEEIAFHIPDEIPIEVDLGFQGLQSEYTNIRIPHKKPRGGELSDEQKQENRSLSQSRVLCENAFAGIKRYGAVSAIYRNRIKDFDDRLMLTAAGLWNFYLMAA
>NZ_AP018205|131974:291391|152783_153179_-|WP_017291639.1|DBSCAN-SWA
MESQRTRQIQTTPNDFYSLFIKKLKSKGITLDNVLQFEQKPTFKKGDIAQRFEAYVQKDEHLYRIDQQGKKIPLAKRYIFQKFANHYAHEIIQTLGLEVKPLAQMRSLSKADRLIQFIRQSPQDLEEQILL
>NZ_AP018205|131974:291391|148579_150364_-|WP_017291636.1|DBSCAN-SWA
MASRKWLAELIQSQYIPFIQSVKNTAAGHKKLEKFTEELRQSWAERGLISLKQQQGCMDQIRRAIKDGLGEDHFSLDFIAFSTEEYTALNDEKQRSVAERNEDVKYIHDPDRIVAQAVRLLERPDWADVAAGLAVLTGRRVTELLATARFEPKTKWSVTFTGALKRRQETQTLSFEIPTLTTADKVCKALTKIRQQLPEAQSMSANKINQKFSQRVAVACDRHFENLVPSRAGGNLYTHLFRAVYATIATFWYCPANIDTVEFRAAIQGHYQILDKKSPTLKRSLAASRHYADFDIADSVIAQHHGKRKGIKLGHGGIEPIAAFKQEASVEQLEQPKRTSRKRSTLSYYTQDHDRWISILQLIAPDAKNQSERTAKLLEWIEAQFQQTPVEPASSQPQEPSPIVEIEPPSLEIQPIEDTPPKLDPTVQLLVEQMAQVMQSVAKLTDAISAGQLERTSPQRQRSTPSSTQTLHSTQSSTASTENPQPARPRGPRGASGEIVDRAIDAMMAYNDMAERLHQDKWAISINILKEFVSSQPAIQRGLEQREAEIRAHHEQHQIDPKKHNFFHRGKHKITDFIQIETEPQNQESDAIPN
>NZ_AP018205|131974:291391|276348_278940_+|WP_017291706.1|DBSCAN-SWA
MMSAKAWLWAVVPFLALLQGVKPADAQVSRLPEIESISTAAGTVVAQAPPTVERVNITDVQVRSTENGLALQLTTAPNAALKPIIQTSGNRWIATFENAALALPSGQSFQANNPTAEISQVQVQQVSNIQVQVEIISKSELPNVEIAPTAAGLSLTVLANGKTSSDTATRSDAESEEEEVVVTATRTEEPLKKVPRSITIINRQQIEEQSRLTRNLGDILANTVPGFSAPTQRTNTFGSTLRGRGISVLIDGVPQNGNLQSLPTQLTSIDPSAIERIEIVRGPNSIYGGQATGGTINIITRKPSNQLTSTLELGTTTALTGSEDKFGYNLQYQLSAKQGAVDLTTGIGLTTTGTFYDAEGDRIANSVSPDDTQILNGLLKVGVDLDPQQRLQFTATHYNNRRNNNLTEDASIDVIPGIQKARTLAIDGLQILGTTEGSYIRNTNVALDYTHQNLFGSKVQGQVYYRNNAFRGSGIPFDGRDFLGVIGRTPGESEQFGTRLQVNTPFNPDKTLQLLWGVDYNNEKSFQNIEVFDPEAFDASGGSVFRKIAERTFVPRYTVNDLGLFAQLQWDANDRLNLSGGLRYVNLGLKIDDYVTINDQAVQGGDRQFDTVAFNAGATYQLSDQLSAFASFSQGFSVPSFGFILREPPSGFTRVTDAIRLTEPQKVNNYEVGLRGRWSTVQASISGFYNTSDLGEDFRLVNNNLEIVRAPQRTYGVEATLDWQATKTLSFGGTLTWQEGENDEDEDGNFLALNSITVPPVKLTAYVENETLPGWRNRLQLLYSGNRDRAFQDGVDGGKISSYVTLDFISRIQLGQGELQIGIQNLLNTQYFPVYSQYFAPFFDSANYAGQGRTLSVTYRVTF
>NZ_AP018205|131974:291391|212305_212611_-|WP_017291678.1|transposase|DBSCAN-SWA
MTLHTIPTEVAIAVDLGFQGLQNQYDNIKIGHKKPKKQALTEQQKQENRELSQHRVKCEHAFAGIKRYNAVSHVYRNHVADFDDRLMLTAAGLWNFYLIAA
>NZ_AP018205|131974:291391|279091_279316_-|WP_017291708.1|integrase|DBSCAN-SWA
MRWIETQTGIDLHSHRGRHTYATNLLIKYGLGEGEAMKLTRHRDRRSFKRYTNKKEIYAAQVAILRASGQLPSS
>NZ_AP018205|131974:291391|177498_178554_+|WP_086371085.1|DBSCAN-SWA
MTSKQSLQVIQQSLVLLLTVPFLSLSGCNSASTTSQSPSTTVSPASTASNEGKAGRFALIMNGPPTDKSWNQKAYEAAQALKAKGVDIVVSESISPADVERVLRQYAEAGYSPIVAHSFNYGDAVFKVAKEFPNINFAWAGGINKTGVNVADYDQPFYQGAYLVGLIGGKLSKTGKLGALYGFDIPVCHSMGEAMLAGAKTVRPDATLTDAAVGNWDDVAKAKEAALSQAETGVDFWIGCGQGPTLGQIEAAKTKGGFVTGYVGDMSSIDPKVVASNLVWNMEPLFTKMIEDTRSKQFTNQFYKMGVAEGVVGVEIPSAFKDKLTPEQLKSIEDTRTKIASGELKVPFVPK
>NZ_AP018205|131974:291391|229228_230536_-|WP_017291694.1|DBSCAN-SWA
MRTFVIVWSGQLVSAIGSYMTHFAITLWAWQLTGQATALTLIIFSSQVASLVVTPFAGVIVDRYDRKKLMMLSDAVAALSTVAILSLYLTGHLQVWHFYVTSAINGVFSDLQEIAYSASIPMMVSKQDYTRASSMGSVLHYSSNIFAPALAGILYYSIGLLGILLIDLLTFCIAILTVFRVHIPQPVASRPSLQSQTTLLQEMLVGFRYVFAQPGLFALLVAALLFWFAHDIGASLYSAMVLARSNNNASVLASLSAIAGVSGVIGAIIMSTLGGPKRKIHGFLLGMVGAGISKAIFGLGQSPLLWFPSQFCSSLNFPLLGSSNDAIWLAKVSPERQGRVVATRSLLLLVVSTIAALMAGPLADRIFEPAMMPEGWLAGIFGSIFGTGSGAGMALLYVISSIGLVLVGAIGYWIPTLRDMETTVCDHDVEPYSSK
>NZ_AP018205|131974:291391|131974_132886_+|WP_026148520.1|transposase|DBSCAN-SWA
MEPIVSRLDLTALFCDVDDFCQTFEWAWAHQPQLPSMPGEKRSRSRLRLSEVMTIVIAFHASGARTFKDFYTLTVLPHWRKAFPNLVSYTRFVELMPWCLMLLCCFLMTRRGEMTGIAFVDSTPIEVCHPARAHSHKVFKHQVGWGKSSTGWKFGFKLHLIINEHGELLAFKLTPANTDDRAPVAEMTEGIFGKLFGDRGYISQKLFEELYERGLKLITKRKRNMKQKLVTLMDKILLRKRSLIESVNDQLKNICQIEHSRHRSYWNFLVNLMAGLIAYTYQPKLPSLDLQPKGLPALPPAIF
>NZ_AP018205|131974:291391|263542_269236_+|WP_017291702.1|DBSCAN-SWA
MSDLSQRLAALSPEKRALLLQRLHQTSQHPTPTQIQRQARSTNTFPLSFAQQRLWFLNQLEPGNAFYNMPAAILLKGHLNIAALEHSLDALIQRHEALRTNFTTVAGDPVQVIATARSHNLSIVDLHHCSEPEQTQRVQQLAQAEAQLPFDLGNDSLLRVCLLQLSETQHVLLFTLHHIIADAWSLGVLIQEFAQAYSAFSTGESLSLPELPIQYADFAVWQRQWLQGDVLETQLHYWQQQLQHAPPLLELPTDRPRPPVQTFRGAYQSLILPNALMEELKAFSRREDTTLFMTMLAAFKTLLYRYTGQTDLLVGSPIANRNRLEVENIIGVFINTLVLRTDVSGNPTFRELLAQVRKTTLDAYAHQDLPFERLVETLHLERNLSYNPVFQVMFQLQNAPMADLELPGLTLSNLETAGETTQFDLSLNMAETEAGLQALIEYSTDLFDDETIARMLGHFQTLLEGIVAHENDRLSNLPLLTKAEQHQFQEWNQTQVEFAQVPIHQLFEAQVKRTPDAIAAVFEQEHLTYQALNDRANQLASHLQTLGVRPNGLVGICVDRSLEMLVGILAILKAGGAYLPIDPAYPQDRIAFMLEDADVEILLTQSHLSPPLTQSNPKVLYLDSDWTTLSPGSPLPCSPDHLAYVIYTSGSTGKPKGVQIEHHSLSNFIQSLQQHLNLTSQDFFFSVTTITFDIAALELFLPLTVGARVVIASRAVACDGVRLSEALVQSGTTIMQATPATWRLLLASGWQGNAQLKVLCGGEALQADLASQLRSKCAALWNLYGPTETTIWSTIHAVESDNEPVPIGCPIANTEIYVLDRDRQLVPVGVTGELYIGGAGLARGYLNRPELTADRFLQLELPEQQQTRLYRTGDLARYRSDGTIECLGRIDHQVKVRGFRIELGEIESVLCQHPTVQQAAVTVRETEFGDQRIIAYVVPVSASHSEWRSFLNTKLPDYMVPAAFVRLEALPLTPNGKVDRKALPAPSEIPSELDPTLEAAQTPVEEMLASLWSQILGAEIGIHDDFFAFGGHSLLATQLMSRVRDVFNVELPLRVLFETPTIARLAPQIEKAMKTRQQLAIPPLQPVDRTQALPLSFAQQRLWFLSQLAPDSALYNFSAHVRLAGTLNISALEQSVNEVVRRHEALRTAFAVVEGQPIQIIAPTLTLPVPVVDLRSLSPAEQQTAVQHLVDEEDRKPFDLTCCPLLRVTVLRLNATEHVLLLTMHHIISDGWSMGVLLRELMALYEAFCTGQPSPLPALPIQYADFAVWQRQWLQGDVLDQQLHYWKQQLLGGNLPPLKLPTKPSQPKSQNYQGKSHTSELSVDLSRQLQSLSRQENVTLFMTLLAALQTLLHRYTHQDDIVVGTDIANRTHSETESLIGFFVNLLVLRSDMRGNPSFRELLQQVREVTLNAYAHQDLPFDKLVEELQPERNLHQTPLFQVLFVLQNTPVPTIELTDLTLHPLDTQENDLSKFDLALFVTETEPAIQIAWKFNVDRFDPDTIAQMANHFTALLASIVAAPEARLSTLSLQTAAEPKPLHQPRDRKNMSFSKFKSIQPKAISVPETGLVTTSYLQPGEPLPLVVQPNLEDIDLIGWAKNNRGLLETELLKHGAILFRGFNAASVPEFERFAQTICPALFGEYGDLPREEVSQNVYTSTPYPADKAILFHNESSHLHCYPMKIWFFCVQPAQSGGETPIVDCRKVYQLLDPKLQEHFAQKQLMYVRNYTDGLDVSWSRFFHTTDRSVVESYCHNHGIEFEWKANNGLRTREIRPAVATHPKTGETVFFNQIQLHHLSCLDLSVQESLLSLFGEENLPRQVYYGDGTPIEDSVVEEVCEAYRQATVQFPWQKGDILMLDNMLSAHGRNPYGGARKIVVAMGELVSPAETARLEAGNAVAR
>NZ_AP018205|131974:291391|215483_215918_+|WP_017291682.1|transposase|DBSCAN-SWA
MKDIGSLSHTKWECKYHVVFIPKYRKKALYYELRQHLGELFRELAAQKECRIEEGHLMSDHVHMLISIPPKYSVSQVMGYIKGKSAISIARTYQGRRKNFTGQHFWARGYYVSTVGRDEALVRQYIRDQEKEDQRVDQLNFFNE
>NZ_AP018205|131974:291391|228257_229217_+|WP_017291693.1|DBSCAN-SWA
MVPFFCADAARSSNADLIGTASPYKAFIAVECPPPWTPNELDSKSVPANLSTLGEWVNEDYDRFQTCLLLIYNETLNQSGFTRLLIFEQASNFTNTYRQQEFHIADPNEIAPLIQAYLAGEPIDVTPVDNSFRDIFVCTHGSHDKCCAKYGYPLYREATTIVNHLSLHQVRVWQVSHIGGHRFAPTAIDLPAGRYYGHLNGSSLTSILTRTGDIQVLRQVYRGWSYLPWAVQAWERELLLQQGWEWMNYNVAIQVLAQNEDETLTSVELTFETPEGDRQIHRADIIADPNKAVYLKGECDSEQAFPFPQYEVQNWIRIK
>NZ_AP018205|131974:291391|222279_222927_-|WP_017291688.1|DBSCAN-SWA
MLVIQDLGRQIQGRWVWKQINFELYPGERCAIAGEAGAGKTLLLRAIAALDPVQSGTIALQGKSLSDWFIPHYRTQVLYLHQRPALLEGTVEQNLQAIYRMAVRRSPDRYRDQRPRILEYLSILGRSPDFLDHPTHALSGGEGQIAAFLRALLCSPTVMLFDEPTASLDAQTEQRFEALVRLWQQENPVRSYFWTSHNPEQLERMTDQRLTLKRP
>NZ_AP018205|131974:291391|146587_147412_-|WP_017291634.1|transposase|DBSCAN-SWA
MDRLSIDPSQVFLTGQALETVYEWSNTLKSFQQRLSPYFARTEARQAAFNYIQALLSPVERKNGWQIAEQVGNENPYRVQHLLGRAQWDAEKVCQEVRQYGVEGLSESDDIFAVDETGFLKQGHQSVGVQVQYYGTTGHLENCQVGVFLAYITGKSHTLIDRRLYLPKSWADDADKRSKAGVPKTVKFATKAQLAQQMLQAAWDAGLRSAWVVADEVYGNDAGFWWWLEKTGQQPYVLTVNKKQPVVIGWQPNRAEAVKCPPKTRPLQERQETV
>NZ_AP018205|131974:291391|180122_181169_+|WP_017291656.1|DBSCAN-SWA
MLNPSSALSQSSIWLRLKFLAPILGAVLALLLGGVLLQLSGANPVQACQVMFMGAFGGTRQWTETLLKATPLLIIGLGMTITFRCRVWNIGAEGQYYIGALCGSLVALTFPNLSTGLLIPLMLIAGVFGGALWSAIAGLLHLLRGMNLIICTLMLNYISILMVQYAARVPLRQPDGFLPESAQFSSNAQIPVLFGTRLHWGMALALLLVVGVYLLLWHTSIGFHLRVVGSRLSVARSVGINTSRSILLALMMSGGLAGLAGIIEVSYTYTRLKGEISDSYGFSGILVALLGQLHPIGVLIAAILFSALMVGAQSLNVMLQIPASAAQVIQALVVLFVLAGSALANRRS
>NZ_AP018205|131974:291391|207686_207866_-|WP_017291674.1|DBSCAN-SWA
MALKLIAELVRQIDHPGIALLKPYFLEENSPIYPSTNRNRDNLQSNEIKPVGWKESRNL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_026148520.1|131974_132886_+|transposase	IS982 family transposase	NA	NA	NA	NA
WP_017291618.1|132974_133490_-	hypothetical protein	NA	NA	NA	NA
WP_017291619.1|133482_134337_-	ParA family protein	F0PIG8	Enterococcus_phage	4.8e-09	24.7
WP_017291620.1|135034_136240_+	hypothetical protein	NA	NA	NA	NA
WP_017291621.1|136287_136509_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_017291622.1|136832_138023_-	hypothetical protein	NA	NA	NA	NA
WP_017291623.1|137991_138819_-	ParA family protein	NA	NA	NA	NA
WP_017291624.1|139177_139585_+	hypothetical protein	NA	NA	NA	NA
WP_017291625.1|139767_140670_+	ParB/RepB/Spo0J family partition protein	S5VSZ7	Leptospira_phage	1.4e-06	39.0
WP_017291626.1|140666_141365_-	hypothetical protein	NA	NA	NA	NA
WP_017291627.1|142648_142846_-	hypothetical protein	NA	NA	NA	NA
WP_017291628.1|142898_143360_+	hypothetical protein	NA	NA	NA	NA
WP_017291629.1|143350_144001_-	hypothetical protein	NA	NA	NA	NA
WP_017291630.1|143993_144593_-	hypothetical protein	NA	NA	NA	NA
WP_017291631.1|144861_145326_-	hypothetical protein	NA	NA	NA	NA
WP_096735604.1|145440_146570_-|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	1.3e-25	32.6
WP_017291634.1|146587_147412_-|transposase	IS701 family transposase	NA	NA	NA	NA
WP_081614819.1|147587_148607_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_017291636.1|148579_150364_-	hypothetical protein	NA	NA	NA	NA
WP_017291637.1|150405_150588_+	hypothetical protein	NA	NA	NA	NA
WP_017291638.1|150577_152647_+	TraM recognition domain-containing protein	NA	NA	NA	NA
WP_017291639.1|152783_153179_-	hypothetical protein	NA	NA	NA	NA
WP_017291640.1|153501_153825_-	hypothetical protein	NA	NA	NA	NA
WP_017291641.1|153947_154517_+	hypothetical protein	NA	NA	NA	NA
WP_017291642.1|154538_154829_+	hypothetical protein	A0A2H4PAR5	Aphanizomenon_phage	6.8e-08	32.2
WP_017291643.1|155025_156072_-	fatty acid desaturase	NA	NA	NA	NA
WP_017291646.1|157826_158720_+	DUF4118 domain-containing protein	NA	NA	NA	NA
WP_017286974.1|158898_160098_-|transposase	IS701 family transposase	NA	NA	NA	NA
WP_081614820.1|159941_162389_+	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	1.2e-28	27.8
WP_017291649.1|162453_166188_+	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	5.6e-30	31.9
WP_017291650.1|166254_172275_+	AAA family ATPase	W8CYF6	Bacillus_phage	1.4e-25	32.6
WP_017291651.1|172312_175885_+	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	3.1e-25	27.9
WP_086371085.1|177498_178554_+	BMP family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_086371084.1|178672_180136_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	6.4e-22	29.0
WP_017291656.1|180122_181169_+	ABC transporter permease	NA	NA	NA	NA
WP_086371083.1|181180_182149_+	ABC transporter permease	NA	NA	NA	NA
WP_086371082.1|182172_183147_+	aromatic ring-hydroxylating dioxygenase subunit alpha	A0A076FFT9	Aureococcus_anophage	6.9e-12	26.4
WP_096735605.1|183265_188629_+	AAA family ATPase	A0A0G2YB36	Acanthamoeba_polyphaga_mimivirus	2.9e-11	26.6
WP_086371080.1|189095_189935_+	hypothetical protein	NA	NA	NA	NA
WP_017291662.1|190796_192959_-	recombinase family protein	D2KRD2	Lactobacillus_phage	3.2e-09	22.4
WP_086371079.1|193269_193374_+|transposase	transposase	NA	NA	NA	NA
WP_086371078.1|193377_194724_+	hypothetical protein	NA	NA	NA	NA
WP_017291667.1|194711_195260_-	hypothetical protein	NA	NA	NA	NA
WP_017291668.1|195347_199070_-	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	4.2e-25	27.5
WP_017291669.1|199124_202376_-	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	3.4e-23	28.3
WP_017291670.1|202430_205298_-	PAS domain S-box protein	A0A2K9L5I4	Tupanvirus	1.8e-20	29.3
WP_086371077.1|205287_207657_-	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	3.3e-28	27.8
WP_017291674.1|207686_207866_-	hypothetical protein	NA	NA	NA	NA
WP_017291675.1|208185_208518_+	response regulator	NA	NA	NA	NA
WP_017291676.1|208549_209449_-|transposase	transposase	NA	NA	NA	NA
WP_017291677.1|210993_212283_-	response regulator	A0A1V0SGX0	Hokovirus	3.2e-33	29.4
WP_017291678.1|212305_212611_-|transposase	transposase	NA	NA	NA	NA
WP_017291681.1|214443_215208_-|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_017291682.1|215483_215918_+|transposase	IS200/IS605 family transposase	D9CGB6	Hyperthermophilic_Archaeal_Virus_2	8.0e-13	31.6
WP_017291683.1|216124_218050_+	TonB-dependent receptor	A0A0P0I887	Acinetobacter_phage	8.2e-09	33.6
WP_017291684.1|218195_218465_+	hypothetical protein	NA	NA	NA	NA
WP_017291687.1|221479_222283_-	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
WP_017291688.1|222279_222927_-	ATP-binding cassette domain-containing protein	F2Y1V6	Organic_Lake_phycodnavirus	3.4e-07	25.8
WP_017291689.1|223191_224211_+	iron ABC transporter permease	NA	NA	NA	NA
WP_017291690.1|224207_225239_+	iron ABC transporter permease	NA	NA	NA	NA
WP_051077907.1|225331_225613_-	DUF1636 domain-containing protein	NA	NA	NA	NA
WP_017291691.1|225940_226471_-	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_071596259.1|227196_228240_+	iron-siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_017291693.1|228257_229217_+	sucrase ferredoxin	NA	NA	NA	NA
WP_017291694.1|229228_230536_-	MFS transporter	NA	NA	NA	NA
WP_017291695.1|231019_236284_+	non-ribosomal peptide synthase	A0A2K9KZV5	Tupanvirus	9.8e-105	24.4
WP_017291696.1|236288_241076_+	type I polyketide synthase	D0R7J2	Paenibacillus_phage	3.7e-58	41.8
WP_017291697.1|241121_245888_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	5.8e-72	26.7
WP_017291698.1|245894_253718_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	6.8e-203	30.1
WP_017291699.1|253714_259201_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	5.9e-76	26.2
WP_017291700.1|259208_260270_+	hypothetical protein	NA	NA	NA	NA
WP_017291701.1|260280_263550_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	3.5e-84	25.3
WP_017291702.1|263542_269236_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	2.4e-117	28.9
WP_017291703.1|269219_273200_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	2.6e-89	26.1
WP_017291704.1|273221_273977_+	thioesterase	NA	NA	NA	NA
WP_017291705.1|274011_276153_+	acylase	NA	NA	NA	NA
WP_017291706.1|276348_278940_+	TonB-dependent receptor	NA	NA	NA	NA
WP_017291708.1|279091_279316_-|integrase	site-specific integrase	NA	NA	NA	NA
WP_026149073.1|279611_281258_-|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_017291710.1|281495_282257_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	2.3e-47	44.6
WP_017291711.1|282272_283823_-|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	3.7e-100	41.3
WP_017291712.1|283993_284725_-	hypothetical protein	NA	NA	NA	NA
WP_017291713.1|284993_285239_+	hypothetical protein	NA	NA	NA	NA
WP_026149075.1|285407_286100_-|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	7.5e-21	33.0
286431:286456	attL	NA	NA	NA	NA
WP_017291715.1|286488_287733_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_017291716.1|287756_288479_-	hypothetical protein	NA	NA	NA	NA
WP_017291717.1|288501_289107_-	hypothetical protein	NA	NA	NA	NA
WP_017291718.1|289350_290151_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_017291719.1|290344_291391_-|transposase	IS4 family transposase	NA	NA	NA	NA
293433:293458	attR	NA	NA	NA	NA

2. NZ_AP018203

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP018203_1

• CRISPR_ID: NZ_AP018203_1
• CRISPR_location: 897-1018
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP018203_1

Consensus_repeat	Method
TCTGCCTTCGCAGCTTCCTTCGC	CRISPRCasFinder

spacers of NZ_AP018203_1

>1.1|920|31|NZ_AP018203|CRISPRCasFinder
CTTTTTCGCCTCTGCCTTCGCAGCTTCCTTC
>1.2|974|22|NZ_AP018203|CRISPRCasFinder
AGCTTCCTTCACTTTCTTCTCT

CRISPR arrays and Neighbor proteins around NZ_AP018203_1

CRISPR arrays

The CRISPR arrays of NZ_AP018203_1

>merge|NZ_AP018203|1|897-1018|CRISPRCasFinder
TCTGCCTTCGCAGCTTCCTTCGCCTTTTTCGCCTCTGCCTTCGCAGCTTCCTTCGCTTTTTTCGCTTCTGCCTTCGCAGCTTCCTTCACTTTCTTCTCTTCAGCCTTCGCTGCAGCTTTTGC

>NZ_AP018203|1|1|897-1018|CRISPRCasFinder
TCTGCCTTCGCAGCTTCCTTCGC	CTTTTTCGCCTCTGCCTTCGCAGCTTCCTTC
GCTTTTTTCGCTTCTGCCTTCGC	AGCTTCCTTCACTTTCTTCTCT
TCAGCCTTCGCTGCAGCTTTTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017290756.1|302_821_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290763.1|10461_12786_-|FUSC-family-protein	unknown	unknown	gnl|CDD|130728
NZ_AP018203.1|WP_017290762.1|8087_10364_-|FdhF/YdeP-family-oxidoreductase	unknown	unknown	gnl|CDD|273765
NZ_AP018203.1|WP_071596190.1|15870_16116_-|ssl1498-family-light-harvesting-like-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290766.1|14554_15001_+|hypothetical-protein	unknown	unknown	gnl|CDD|213748
NZ_AP018203.1|WP_081614811.1|13992_14505_+|DUF2231-domain-containing-protein	unknown	unknown	gnl|CDD|226695
NZ_AP018203.1|WP_017290767.1|15290_15578_-|hypothetical-protein	unknown	unknown	gnl|CDD|369150
NZ_AP018203.1|WP_017290758.1|1850_3179_+|chloride-channel-protein	unknown	unknown	gnl|CDD|238233
NZ_AP018203.1|WP_017290761.1|6728_7907_+|trypsin-like-serine-protease	unknown	unknown	gnl|CDD|273938
NZ_AP018203.1|WP_017290759.1|3175_4789_-|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl|CDD|129794
NZ_AP018203.1|WP_017290764.1|13034_13592_-|HPP-family-protein	unknown	unknown	gnl|CDD|225979

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017290766.1|14554_15001_+|hypothetical-protein	gnl|CDD|213748	TIGR02891, Probable_cytochrome_c_oxidase_subunit_1-beta, cytochrome c oxidase, subunit I. This large family represents subunit I's (CtaD, CoxA, CaaA) of cytochrome c oxidases of bacterial origin. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits I-III form the functional core of the enzyme complex. Subunit I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit II and heme a of subunit I to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. In the bacilli an apparent split (paralogism) has created a sister clade (TIGR02882) encoding subunits (QoxA) of the aa3-type quinone oxidase complex which reacts directly with quinones, bypassing the interaction with soluble cytochrome c. This model attempts to exclude these sequences, placing them between the trusted and noise cutoffs. These families, as well as archaeal and eukaryotic cytochrome c subunit I's are included within the superfamily model, pfam00115. [Energy metabolism, Electron transport].	1.75341e-52
NZ_AP018203.1|WP_017290763.1|10461_12786_-|FUSC-family-protein	gnl|CDD|130728	TIGR01667, Uncharacterized_protein_HI_1680, integral membrane protein, YccS/YhfK family. This model represents two clades of putative transmembrane proteins including the E. coli YccS and YhfK proteins. The YccS hypothetical equivalog (TIGR01666) is found in beta and gamma proteobacteria, while the smaller YhfK group is only found in E. coli, Salmonella and Yersinia. TMHMM on the 19 hits to this model shows a consensus of 11 transmembrane helices separated into two clusters, an N-terminal cluster of 6 and a central cluster of 5. This would indicate two non-membrane domains one on each side of the membrane.	3.02781e-32
NZ_AP018203.1|WP_017290762.1|8087_10364_-|FdhF/YdeP-family-oxidoreductase	gnl|CDD|273765	TIGR01701, Hypothetical_protein_Rv2900c/MT2968/Mb2924c., oxidoreductase alpha (molybdopterin) subunit. This model represents a well-defined clade of oxidoreductase alpha subunits most closely related to a group of formate dehydrogenases including the E. coli FdhH protein (TIGR01591). These alpha subunits contain a molybdopterin cofactor and generally associate with two other subunits which contain iron-sulfur clusters and cytochromes. The particular subunits with which this enzyme interacts and the substrate which is reduced is unknown at this time. In Ralstonia, the gene is associated with the cbb operon, but is not essential for CO2 fixation.	0
NZ_AP018203.1|WP_081614811.1|13992_14505_+|DUF2231-domain-containing-protein	gnl|CDD|226695	COG4244, COG4244, Predicted membrane protein [Function unknown].	2.85543e-22
NZ_AP018203.1|WP_017290767.1|15290_15578_-|hypothetical-protein	gnl|CDD|369150	pfam06967, Mo-nitro_C, Mo-dependent nitrogenase C-terminus. This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria. Note that many family members are hypothetical proteins.	2.34405e-52
NZ_AP018203.1|WP_017290758.1|1850_3179_+|chloride-channel-protein	gnl|CDD|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	7.93825e-81
NZ_AP018203.1|WP_017290761.1|6728_7907_+|trypsin-like-serine-protease	gnl|CDD|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	5.12952e-119
NZ_AP018203.1|WP_017290759.1|3175_4789_-|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.77392e-123
NZ_AP018203.1|WP_017290764.1|13034_13592_-|HPP-family-protein	gnl|CDD|225979	COG3448, COG3448, CBS-domain-containing membrane protein [Signal transduction mechanisms].	9.46835e-73

Protein sequences

>NZ_AP018203.1|WP_017290756.1|302_821_-|hypothetical-protein
MVVRSSVKFLDRRDRFHAVCIGSLQEIDMKRLFVSVFASLVVLLGFAGRVQATPLSVAPPILSVAEAAPVDVIEQLKTQILPQLQSILTPEQQQQLESAIVEGTPNLPKAMQSLMLTPDQKAKLAGVFKTLPKKEIFASMTPEQKKQLFMSKKDLFMPTAEEIAGYKAMKGK
>NZ_AP018203.1|WP_017290758.1|1850_3179_+|chloride-channel-protein
MVFPFRPKQSKGSRQNQNQRGSWLVSLAERNPFTLSRWIICWALIGVGSGLFAGLYWNLLELLTHTLRSFSGTSLLIVMPFAGFIIGLIIHLLGHPGEIGLIVDNIHSRGGRIDVRENPSMILTSLVSISAGGSLGPEAPMVQVTGSFGTWVADRLKLTGENLRSLSLAAMAAGFTALFGAPLGGAFFALEILHHQHVVEYYEAILPAIVSSCASYIVFALITHLGLNPTWQFPQYTINNVDDFALSIAYGIVGAIAAWIFISIFRGCAWLFAKIPQPIYIRTTIAGLVLGIIAMLVPLTRYFGHEELNSVVEQNLGAFTLLGIAIAKMIAIAVTVNGEWRGGFIIPLFFTGACLGKAIALLIPGVNPVLPMIAIMAAMNAAVTRTPISTTLLLTKLTGFTPFAPILFASLVGFFLSPKLPFIRSQSRTQNQSPLSTLETGD
>NZ_AP018203.1|WP_017290759.1|3175_4789_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MATTRDRSKMQNNSNSTKAQSSYVQGPLKWAIAFTASLGAILEVIDTSIVNVALTDIQATLGATVSEVGWVVTGYAIANVVLIPLSAWLGDVFGKKTYFVFSMVGFTLASVMCGFAFNLPMLVISRILQGLFGGGLLAKAQAILFETFPPAEQGLAQAVFGVGVIAGPAIGPTLGGYLTDSLGWRWIFFINLPVGIAAVLMAIFFLPPDRVQGKKNHQKVDWLGIILLIVAVGSLQTFLEEGEQDDWFNSQFITTLAITTVVGLVLFIWRELSTKDPAVDLRVLRHRSLAAGSVYSGILGMGLYGALFAVPLFAQGVLRFTATQTGWLLAPGALASAIVMILLGKISTKVDARILIAIGAVGTALVMFQLSNITPQTGTEDLFYPLLWRGATTVLMFLPLSLATLGSLPKQDISAGSGFYNLTRQLGGSIGIAILTTLLAQREAFHKAMLLTNLSPYNPETTQRLNALAGAFQNRGSDAATAQQQALTSLDQLVNLQAAILSYADIFRFVGVVFLCSLPLLLLLGKGGAGAKAPIDH
>NZ_AP018203.1|WP_017290761.1|6728_7907_+|trypsin-like-serine-protease
MASIIKPPLVSLTLILASLSTGCVRNLSAPQEQTVTPQAQSSNTPVPTPSNPPVANSGGNPNYVAQVVEQVGPAVVRVNSTRTLQQPTNDPYLRRFFGEQSPTQQRVQRGTGSGFIISQDGRILTNAHVVDNADTVSIVLKDGRRFDAKVLGSDRVTDVAVLKIETTGLPTARLGNSDNLQPGQAAIAIGNPLGLDNTVTEGIVSATGRSSSDVGVPAERVRFIQTDAAINPGNSGGPLLNANGEVIGINTAIIQGAQGIGFAIPINTAQQVAEQLITKGQVTHPYLGVLMTDLTPELRDQINRSNVGFQVNQTTGVLIVRVAENSPAARAGLRPGDVLISINGNAVQNTEQVQKTIEGAQLNNPLPMTVQRNDRSVAVNVRPTQLPPPDAS
>NZ_AP018203.1|WP_017290762.1|8087_10364_-|FdhF/YdeP-family-oxidoreductase
MSANPQDIQPVPPFNEKNEEALDIGGGLPVIQFWAEKTLSPEGAKIWQTLFHHSACLSCSWGTGGQKGGFTDEEGEKLQRCMKSVEAISAEIKPGIKPHFFEQHSITELQQLSSMQADRLGRLSYPVILRAGSSHYERISWEEIYSIAEAGFRKAPERVASYSSGRSSNEAAFLLQLMMRAFGSNNLADCSDLCHAPSTFALQQMFGTKTSIVSLESLKKADCVVLAGANSAYNHPRLMNELIKLRDDRGGRVIVINPMMEIGLVKFGSPAFPVKSLIPGSEISSLYLQPIPGSDVAVFLGIQKALIEQGSVDRAFLDAHTENAEAVLEQASATSWETITSTCGVTQEELEAAATIIGTSKSVVFAWAMGLTQHENGVDNILSIANTALISGNIGREGTGVMPVRGHSNVQGFGSMGVTTQKLKEGLQESLEKLLGKPLSSVKGYDTRALIEAADQGKVDTLICLGGNLYGANPDSTQAKRAIAQIETVIYLATKPNIGHFNGLAQHNTIIIPVFNRFETPYRTTVESGNNFVRLNDPGKTHLKDADVILEIDFLTELAHRVHGSYPVEWRNLRDPKYVRQLIAEMVPGFSKMATIDDTREEFTIEGRIITEPKFPTPSGKAKMFSTPLPRLELPDRASFSVDDSIPSVVVAIMTGRSYSQHNTVVYKDGDKYRGMPHRNCILMHPTDAEKAGLKQHQRVTVQGNAGKLEQVELIYGAVRPGAAVMFYPEVNRIFSAKVETRSGTPAYKRVPAIVYAS
>NZ_AP018203.1|WP_017290763.1|10461_12786_-|FUSC-family-protein
MFSTLLALSNGFLQQFQLKPGQPAIAVSFQVLLSVLGPLIVGIVIGQPAQSTIAIMGAWMVAIVNVEGVYRQQATAKFVAIISITAMLLLANLVHGILWLSVLTTFLVMFLLGFAGLWGATASAISLTASIMFIVALAKFATFPNLSTVLQQCLLCFGGGIWSIIVALGIWQLNPYKPVIQSVSSCYQALNQLIDAAKGRVAYPDDRRAQFTRFLQAQDSFTQALTAARDRWSAAWTEGARNLAGNQLLILIEDTPTIANYTVTLVEQVVVVSDHSLFQSLQPAIQQSLEQLAVVLQQMSTAIAKGRSSIHLGDLDRAIEALRHQQQILHTQFHSNLGSTPPDHQTALTSLDKISTILTRLSGQLYTDVELMTALEQETVHRRVRSARTRSRLSFPKPANFAEVFTPLRDHLTVHSIFFRHALRLAIVATIAEVLAAQLQIPQGYWVTLTAVIALKPNYGGTSQMILQRVIGTVIGGVIGIAIVALIHNSWVISVCLLLLIMGAMAVQPLSIILFITLLTPAIILLLNATSQGGWEIGVLRIADSLAGGVLALLGSFLLFPQWERQQLPAQLETTIRANLIYFQQVIAAYLHPDKVGSAQSIALPRRQAALENTNLTASAQRLFSEPRNVQGDVESITTLIFYIRRLFNSVTALADHRQELSGKYQCPEFTQFADMVVQVLENGADSLQQRQTLQSLPDLDRVLDGIHHHLNQLQTAHTSVTPGSRTSTQIFHAVRERAPVSVGLDQIAYEIKNIHHAIAQLSQPVVEQKLNLS
>NZ_AP018203.1|WP_017290764.1|13034_13592_-|HPP-family-protein
MLHYKKARLKWESYWFKTLGRWQSCPLTCPVDRPHHRHVFWSWFGSFVAISVTSYLAVKTNSPLLMAPFGATSVLIFGVPDSPLAQPRNVIGGNLLAAIISLIILHVFGTSPVAMGMAVSTAIGIMQMTGTVHPPSGAVALVVMMTKPDWQFLLTPALEGSLILVLCAVVFNNLAEERTYPKHWF
>NZ_AP018203.1|WP_081614811.1|13992_14505_+|DUF2231-domain-containing-protein
MTLGLFIIAIIFDIAGTLFPLEKPIFKFFGLTALRSSLFTVGWYNLFAATVITFFTVAAGFFELFLATPPPGTSAWGLSAGTTMLIHGVAGVFILTAIVGMTLWRGLQRYRWRRSARREVQWSYLLVGIAMLGILFIHGTLGAQLGDEFDIHNTAANLVRQGQNPNLVLK
>NZ_AP018203.1|WP_017290766.1|14554_15001_+|hypothetical-protein
MAIFAAIYFWFPKITGHMYAEGWGKLHFWLTFLGANLTFLPMHPLGLQGMVRRVAAYPPEYQNWNVIASLGAFLLGLSTLLFIANVVASLFLGSRASDNPWEATGLEWMTSSPPPRENFEEIPQVMFPPYDYGNPRAYGENDPPQEPS
>NZ_AP018203.1|WP_017290767.1|15290_15578_-|hypothetical-protein
MLNFTSHRFITSLLQPIAAKLDAVEIRSPEAAHFFCRLIPSQCPFERDIRFFGRVLLHIPPMCKLNPFYEQLVGLRFKALCYLADVCGEDIAIYC
>NZ_AP018203.1|WP_071596190.1|15870_16116_-|ssl1498-family-light-harvesting-like-protein
MLTVCNNTVTLVYRTKQITFLEAIAMYTTRNEDGILNNYPSEPVMYFAEFPSSEQQQTYVTQGAIAVLLITFTFLMALAAS

Crispr_ID: NZ_AP018203_2

• CRISPR_ID: NZ_AP018203_2
• CRISPR_location: 107018-107123
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_2

Consensus_repeat	Method
CTAAAGCTTCACTAAATCCCAAGTCAAA	CRISPRCasFinder

spacers of NZ_AP018203_2

>2.1|107046|50|NZ_AP018203|CRISPRCasFinder
GTCCGAAATATTTTCTAACTCGACTGCCGGAGATTCATCAGCGAATGCCT

CRISPR arrays and Neighbor proteins around NZ_AP018203_2

CRISPR arrays

The CRISPR arrays of NZ_AP018203_2

>merge|NZ_AP018203|2|107018-107123|CRISPRCasFinder
CTAAAGCTTCACTAAATCCCAAGTCAAAGTCCGAAATATTTTCTAACTCGACTGCCGGAGATTCATCAGCGAATGCCTCTAAATCTTCACTAAATCCCAAGTCAAA

>NZ_AP018203|2|2|107018-107123|CRISPRCasFinder
CTAAAGCTTCACTAAATCCCAAGTCAAA	GTCCGAAATATTTTCTAACTCGACTGCCGGAGATTCATCAGCGAATGCCT
CTAAATCTTCACTAAATCCCAAGTCAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017290858.1|96473_96965_-|phycocyanin-subunit-alpha	unknown	unknown	gnl|CDD|271303
NZ_AP018203.1|WP_017290861.1|99748_100834_+|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270275
NZ_AP018203.1|WP_017290874.1|118816_119137_+|hypothetical-protein	unknown	unknown	gnl|CDD|350852
NZ_AP018203.1|WP_017290867.1|112877_113153_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290864.1|102718_103789_-|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340832
NZ_AP018203.1|WP_017290859.1|97024_97546_-|phycocyanin-subunit-beta	unknown	unknown	gnl|CDD|271301
NZ_AP018203.1|WP_017290855.1|93092_94790_+|iron-uptake-porin	unknown	unknown	gnl|CDD|335962
NZ_AP018203.1|WP_017290871.1|115562_117344_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NZ_AP018203.1|WP_017290863.1|101196_102573_-|glycosyltransferase-family-1-protein	unknown	unknown	gnl|CDD|340830
NZ_AP018203.1|WP_017290860.1|98435_99353_-|taurine-dioxygenase	unknown	unknown	gnl|CDD|181947
NZ_AP018203.1|WP_017290868.1|113149_113680_-|chemotaxis-protein	unknown	unknown	gnl|CDD|238374
NZ_AP018203.1|WP_017290854.1|91963_92320_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290872.1|117460_118432_-|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|274129
NZ_AP018203.1|WP_017290856.1|94799_96086_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
NZ_AP018203.1|WP_017290870.1|114185_115418_-|response-regulator	unknown	unknown	gnl|CDD|381129
NZ_AP018203.1|WP_017290866.1|110254_112894_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|214599
NZ_AP018203.1|WP_017290875.1|119155_119542_-|hypothetical-protein	unknown	unknown	gnl|CDD|370166
NZ_AP018203.1|WP_026148973.1|118596_118815_+|DUF433-domain-containing-protein	unknown	unknown	gnl|CDD|225291
NZ_AP018203.1|WP_017290869.1|113691_114057_-|response-regulator	unknown	unknown	gnl|CDD|381164
NZ_AP018203.1|WP_017290853.1|91709_91895_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017290861.1|99748_100834_+|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	gnl|CDD|270275	cd13557, PBP2_SsuA, Substrate binding domain of sulfonate binding protein, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes the sulfonate binding domains SsuA found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.08686e-123
NZ_AP018203.1|WP_017290874.1|118816_119137_+|hypothetical-protein	gnl|CDD|350852	cd18770, PIN_Mut7-C-like, uncharacterized subgroup of the Mut7-C-like family of the PIN domain superfamily. The Mut7-C-like family of the PIN domain superfamily includes the C-terminal domain of Caenorhabditis elegans Mut-7 (also known as exonuclease 3'-5' domain-containing protein 3 homolog) Mut-7 is involved in RNA interference (RNAi) and transposon silencing in C. elegans. The Mut7-C PIN domain family is recognized as a genuine PIN domain, however it is not included it in the CDD PIN domain superfamily hierarchical model as it is lacks a core strand and helix (H3 and S3). The PIN (PilT N terminus) domain belongs to a large nuclease superfamily, and were originally named for their sequence similarity to the N-terminal domain of an annotated pili biogenesis protein, PilT, a domain fusion between a PIN-domain and a PilT ATPase domain. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Other PIN domain families are: the FEN-like PIN domain family which includes the PIN domains of Flap endonuclease-1 (FEN1), Exonuclease-1 (EXO1), Mkt1, Gap endonuclease 1 (GEN1), and Xeroderma pigmentosum complementation group G (XPG) nuclease, 5'-3' exonucleases of DNA polymerase I and bacteriophage T4- and T5-5' nucleases; the VapC-like PIN domain family which includes toxins of prokaryotic toxin/antitoxin operons FitAB and VapBC, as well as, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and, rRNA-processing protein Fcf1; the LabA-like PIN domain family which includes the PIN domains of Synechococcus elongatus LabA (low-amplitude and bright); the PRORP-Zc3h12a-like PIN domain family which includes the PIN domains of of RNase P (PRORP), ribonuclease Zc3h12a; and Bacillus subtilis YacP/Rae1-like PIN domains. Matelska et al. recently classified PIN-like domains into distinct groups; this subgroup includes some sequences belonging to one of these, PIN_16.	3.67406e-10
NZ_AP018203.1|WP_017290864.1|102718_103789_-|glycosyltransferase-family-4-protein	gnl|CDD|340832	cd03802, GT4_AviGT4-like, UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.	4.96473e-153
NZ_AP018203.1|WP_017290859.1|97024_97546_-|phycocyanin-subunit-beta	gnl|CDD|271301	cd14768, PC_PEC_beta, Beta subunits of phycoerythrin and phycoerythrocyanin; phycobilisome rod components. phycobilisomes (PBSs) are the main light-harvesting complex in cyanobacteria and red algae. In general, they consist of a central core and surrounding rods and function to harvest and channel light energy toward the photosynthetic reaction centers within the membrane. They are comprised of phycobiliproteins/chromophorylated proteins (PBPs) maintained together by linker polypeptides. PBPs have different numbers of chromophores, and the basic monomer component (alpha/beta heterodimers) can further oligomerize to ring-shaped trimers (heterohexamers) and hexamers (heterododecamers). Stacked PBP hexamers form both the core and the rods of the PBS; the core is mainly made up by allophycocyanin (APC) while the rods can be composed of the PBPs phycoerythrin (PE), phycocyanin (PC) and phycoerythrocyanin (PEC).	1.00076e-96
NZ_AP018203.1|WP_017290855.1|93092_94790_+|iron-uptake-porin	gnl|CDD|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	1.48263e-34
NZ_AP018203.1|WP_017290871.1|115562_117344_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.61877e-10
NZ_AP018203.1|WP_017290863.1|101196_102573_-|glycosyltransferase-family-1-protein	gnl|CDD|340830	cd03800, GT4_sucrose_synthase, sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.	1.29579e-162
NZ_AP018203.1|WP_017290860.1|98435_99353_-|taurine-dioxygenase	gnl|CDD|181947	PRK09553, tauD, taurine dioxygenase; Reviewed.	1.00741e-89
NZ_AP018203.1|WP_017290868.1|113149_113680_-|chemotaxis-protein	gnl|CDD|238374	cd00732, CheW, CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.	2.64189e-30
NZ_AP018203.1|WP_017290872.1|117460_118432_-|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	2.07478e-67
NZ_AP018203.1|WP_017290856.1|94799_96086_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.34269e-71
NZ_AP018203.1|WP_017290870.1|114185_115418_-|response-regulator	gnl|CDD|381129	cd17602, REC_PatA-like, phosphoacceptor receiver (REC) domain of PatA and similar domains. Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.	7.86598e-41
NZ_AP018203.1|WP_017290866.1|110254_112894_-|HAMP-domain-containing-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.03934e-67
NZ_AP018203.1|WP_017290875.1|119155_119542_-|hypothetical-protein	gnl|CDD|370166	pfam08872, KGK, KGK domain. This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	2.34452e-08
NZ_AP018203.1|WP_026148973.1|118596_118815_+|DUF433-domain-containing-protein	gnl|CDD|225291	COG2442, COG2442, Uncharacterized conserved protein [Function unknown].	2.67752e-21
NZ_AP018203.1|WP_017290869.1|113691_114057_-|response-regulator	gnl|CDD|381164	cd19937, REC_OmpR_BsPhoP-like, phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators. Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.86272e-40
NZ_AP018203.1|WP_017290858.1|96473_96965_-|phycocyanin-subunit-alpha	gnl|CDD|271303	cd14770, PC-PEC_alpha, Alpha subunits of phycoerythrin and phycoerythrocyanin; phycobilisome rod components. phycobilisomes (PBSs) are the main light-harvesting complex in cyanobacteria and red algae. In general, they consist of a central core and surrounding rods and function to harvest and channel light energy toward the photosynthetic reaction centers within the membrane. They are comprised of phycobiliproteins/chromophorylated proteins (PBPs) maintained together by linker polypeptides. PBPs have different numbers of chromophores, and the basic monomer component (alpha/beta heterodimers) can further oligomerize to ring-shaped trimers (heterohexamers) and hexamers (heterododecamers). Stacked PBP hexamers form both the core and the rods of the PBS; the core is mainly made up by allophycocyanin (APC) while the rods can be composed of the PBPs phycoerythrin (PE), phycocyanin (PC) and phycoerythrocyanin (PEC).	9.50606e-100

Protein sequences

>NZ_AP018203.1|WP_017290864.1|102718_103789_-|glycosyltransferase-family-4-protein
MRIAQVTPLWERVPPPAYGGIELVVSLLTDELVRRGHEVTLFATGDSITLAQLESVHPRAIRNDPTVKEYQIYETMQLGNVYQRAHEFDIIHSHMGCPALPYAQLVKTPTVHTLHGTFTSDTSKAYAYARSQPYVSISDAQREPSLNMNCVATVYNGIDVDSYKFYAEPNDPPYLAFLGRLSPEKGPHHAIEIAKRTGMRLKMAGKVDIVDQEFYEEVLLPQIDGEQIQYLGEANHVQKNILMGEAVATLFPITWREPFGLVMVESMAAGTPVIAMRLGSAPEVIRDGKTGFLCETVDECVAALDRVAEIDRAVCRQHVIENFSVQRMTDGYEAVYRQLLGERLFQVNGKVLSKFK
>NZ_AP018203.1|WP_017290863.1|101196_102573_-|glycosyltransferase-family-1-protein
MVISPEKNVKSSIQKAPRQSIALISEHGDPAAEIGREEAGGQNVYVRQVGEALSRLGWQVDMFTRKANPDDATIVQHNPHCRTIRLKAGAEEFVPRDQLFEFMPEFVESFLKYQAKQNYPLIHTNYWMSAWVGLEVQKTHNVELIHTYHSLGAVKYQSVPNRPTIAETRLAVEKQILEQARCIVATSPQEEMMLRSLVSDAGRIEVIPCGTDLKRFHVIPKLDARKELGLKPTDEVVLYVGRFDPRKGIETLVRAFALIHHSSADPSNLKLVIVGGSAADKLDGDERQRIEQLVADLGIAENVIFAGRVGHDRLPLYYTAADVCAIPSHYEPFGLVAIEAMACGTPVVASDVGGLKFTVVPGETGLLVPPQDTAAFAEAIGRILDDELWARKLRKRASERVQQNFSWTGVSAQLSDLYRRSLAESIMGDGVILAPRKVAYSRVNTIPAKSLTNLTKVS
>NZ_AP018203.1|WP_017290861.1|99748_100834_+|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein
MLNRIFIVLRSVVGRSFSLRDSTLAIPVWLRFALLGFGLSIAIAACSPTTPTVSNSPNASPVATNAPASNVVRFGIQKATILLKTKGDIDKRLASEGVKVEWTEFPAGPPMLEALNAGAIDIGPVGESPPIFAQAAGAALTYAAAIAPNPKGNGVLVLKDSPIQSVADLKGKKVVFAKGSSANFLIVQLLEKAGLKFSDIEPIYLTPADARAAFVKGDADAWVIWDPFFAAAEVGTNSRVLADGTDVNKLGGYYIASRKFAAEQPKILKAILEEVRNLENWSDKNRDEVATVLTDALKLDAEAVKKATQRRVFGLTAVTNDIIAEQQRVADTYYQLKLIPKPVKVQDAILPPDQVAAFALN
>NZ_AP018203.1|WP_017290860.1|98435_99353_-|taurine-dioxygenase
MTTTTSLKVQPIAGRIGAEIGEIDLRDALTNETIGEIRKALVHYKVIFFRNQNLDADGQVAFARRFGEVTTAHPTVPSLEGQPEVLDLDYDRTVARANHWHTDVTFVDRPPLGSVLRAVTIPPVGGDTVWANSVTAYQDLPESLRNLADQLWAVHSNAYDYAAPALDLSEEFRAYREVFTSTVYETVHPVVRVHPESGERGLFIGGFVRRLQGLSQTESNDLIRLLQSYVTRLENTVRWRWQAGDVAFWDNRATQHYAIADYGNQSRRMQRVTISGDLPLSVDGKHSQALKGDSSSYTPQEPVIA
>NZ_AP018203.1|WP_017290859.1|97024_97546_-|phycocyanin-subunit-beta
MVQDAFTKVISQADARGDYLNPGQLDALLGLVRDGNKRIDVVNRISGSASAIVANAARSLFEEQPQLIAPGGNAYTNRRAAACLRDLEIILRYVTYSIFTGDVSILEDRALNGLRETYLALGVPGASVAAGIQKLKEASLAIAGDPNGVTQGDCSSLLAEVATYFDRAAAAVG
>NZ_AP018203.1|WP_017290858.1|96473_96965_-|phycocyanin-subunit-alpha
MSKTPLTEAVSAADSQGRFLSSTEFQVAFGRFRQAASSLEAAKQLSSKAPSLAEAAANAVYQKFPYTTQLQGPNYASDARGKSKCVRDIGYYLRIISYALVAGGTGPIDDYLIGGLSEINRTFELSPSWYIEALKHIKSNHGLTGDPAVELNSYIDYVVNALS
>NZ_AP018203.1|WP_017290856.1|94799_96086_-|MFS-transporter
MANLYQRFSKQVRFKLHLPAFRSRNFRLYFLGQTFSLSGTFMTQVAVPWLIYDLTHSPWLLGLAGFLGFLPTLILLPLAGVLSDRWSRHYILTIVQLLGMVVSGTLTALVFTGMANFQSLLLLSVLLGMVKGLDMPIRHAFVSEMVTEREDLANAIALNSIMLSSSRLFGPALGGILLATVGAGFCFLFDTLSYLAAIWALASMRLNRPAISKSKVSAWKSLKEGFNYVQNFLPVRMIILLLAIQGVFGISYTALLPVFAADILRGGASSLGFLSASGAVGSVLACVYLSQRRGIAGLERTIGLCPAVIGIGLIAFSVSRSFLLSLAILVFVGAAGTLQVACSNTVVQSIVEESKRGRVMSIYAMSLVGMMPFSNLIGGTLAHYLGAPQALMVCAIVCFLGSTWYGQKLPDLTRSIQMVTASRQSVNL
>NZ_AP018203.1|WP_017290855.1|93092_94790_+|iron-uptake-porin
MLKISWNSRFSWSLFLSTGILLASTSHATKAAASEVTPLPLEQTRSNLPTPNVSQIEQSLDSTVQPINRLSNQVTSVSQLSDVRPTDWAFQALQSLVERYGCIAGYPNRTYRGNRALTRYEFAAGLNACLDRVNELIAAATADLVKKEDLATLQKLQEQFATELATLRGRVDKLEARTTTLEKQQFSTTTKLQGDAIFIAADTFGNRANNTAANDTQDDTQAFFAYRVRLSLLTSFTGKDLLFTRLAANNVPNLQTSTGTAETRLTIDRSSFPESSLYLDSLHYRFPLGNQTTVWVGTRQLQPVVFAPNLNPLIGGANGAISRFATHNPTIYRPGFDGAGVGVSHQFSPQLRFGLGYLTDDTQAPNPNAGRGIFSGNNLLYSQLTFTPSRNFDIAFSYGRKYFGSNTGFNLTGGTGSAFARNPFQQNATVSDNFGLQFLWKTSPTLQIGGWFGYTRAFQVKGAENEATILNGAISVAFPDLFKKGNLGGIIVGIPPKATSNNFRPTPTAARRVDSDTSLHLEAFYTFKVNNNVSITPGVFLITNPEQNRNNDSILVGTVRTNFSF
>NZ_AP018203.1|WP_017290854.1|91963_92320_+|hypothetical-protein
MRYKKFAGGITVLSLCFALAPITKVGASEKSVAIVTPNIPSNVAGANAFNLSNLARSGYLEGIPSGSQLSWELATGRITAHDIVKAGVQANQVSSDALNNPAYIRAIELNLAEPRISD
>NZ_AP018203.1|WP_017290853.1|91709_91895_+|hypothetical-protein
MNLQLSYQSDIDLKEAEALGKSDIETTFISISKLTDKCTQLILKTRFAARHRAKNISSLEI
>NZ_AP018203.1|WP_017290866.1|110254_112894_-|HAMP-domain-containing-protein
MARGNEFAQEYQQAERAYMQGKYEEAAGIVDRLVDNYPQDPSARLLRGHIYCYGLQKYDVAQEQYQSVLDLTSDPEFVDYANSGLAYAGQFSDSSADSFADTSLETDYSGFDESAYLSQESANSLDDFAFDDDFKATTEESSSFGNPFGAQHNGDGSKVGASIGLDDPFAVSASSDAPFSMQDESVVSQDFSNALDDFDQVFASDDEPSHGSMSTVSTDPGMSQGDMAVPISRVTSRDTSEETLFMAAPGFYDEQAAAAFEMPTEQNKFAPIYDEPQNGSRNHPVSTPGNQSNVDFLDDFEDFDDLGNLSDFDLSEDSAGFTSPSIGSAFGFNSNMSAASDSAEVDFGQGSDFAPSNRDGSAFQDDELFSMSSTTEQVPSFTTQLDVPSSEPTPTVEQGWLAPLENASFATKQLIAAGAAGIVSAVAVAVVSFVASNQAAQNNNGAVVSQLRTTGIVMALASGVCGGGAAFAVGQMTARHMKRSTDDLKAQFDSVCQGNLQARATVFAEDELGQLSTNFNQMTRVILTTTSEAQRKAEEQEQAKEDLQRQVIRLLDDVEGAARGDLTVQAEVTADVLGAVADSFNLTIQNLREIVQQVKQAARQVSKGSTENEMFARSLSSDALRQAEELAVTLNSVQVMTNSIQRVAESAREAEEVARTASSTALKGGEAVERTVAGILEIRETVAETTRKVKRLAESSQEISKIVALISQIASRTNLLALNASIEAARAGEAGRGFAIVADEVRQLADRAAKASKEIEQIVLQIQGETGSVMTAMEEGTQQVIEGTRLAEQAKRSLEDIIQVSSVIDTLVRSITADTVEQTETSRNVAQVMQSVELTAQETSQEAQRVSGSLQNLVGVARDLLTSVERFRVETVDRK
>NZ_AP018203.1|WP_017290867.1|112877_113153_-|hypothetical-protein
MKQCLIDSSHYSDQFVDSVKEQGNYFAKESSLNGKDLFAEGGGENLKFFSVHFAILGRSMYYSHFTLTAPIFKSRFQSSTYLQEEAYGTRK
>NZ_AP018203.1|WP_017290868.1|113149_113680_-|chemotaxis-protein
MVGSPDFLTGRGQDQAPEFQELESPEGELHLRFYTPSGAEFALPATGIREVLSPSPDRITPVPNVSPLLLGTLNVRGRVVWVADLGQFLGDAASLNTDRPEISVIAIEDQDIMLGLAVDRILGMEWLDIENVQATTAAPDSVAPFLRGEWVLGQDGSQCLRLLDQVAILRSARWAA
>NZ_AP018203.1|WP_017290869.1|113691_114057_-|response-regulator
MSTVLVVEDSVTQREMITDLLKGSGIEVTIATDGVEALEHIQGHCPDLVVLDIVMPRMNGYEVCRRLKADPKTQKVPVVMCSSKGEEFDRYWGMKQGADAYIAKPFQPTELVGTVKQLLRG
>NZ_AP018203.1|WP_017290870.1|114185_115418_-|response-regulator
MQGQLSEIDIRSILQLIELGQRTGELFVEAYSPSGVVHRRSRNHPSWFVFFLNGQIVYAGETESDLSRLRDYLHRYRAETTIDQIPASSIATFNTPEYGCLWALLENHLVTPAQGRSIIQGMVRETLFDLLSLHQGSFIFELGNALTPQLLTMEIAPLARNALKQVQEWKQLHPYLHTPDQCPIIVDREQLSAALPKATYQLLDRYTDGQTSIRQIARYLNRDISAVARAIYPYVQRGWLQLNAVHPSVHSTSRTPLELGLNAKAPKVLCIDDSSTVCKAVELMLDRNGYDISTIENPLTALSLVFQIKPDLILCDIAMPELDGYELCAMLRQSTAFRQTPILMLTGKDGFIDRVRARMVGATDYLTKPFGEHEILMLLEKYVGVGHPEILTTTQQVLDALEAELNLNAS
>NZ_AP018203.1|WP_017290871.1|115562_117344_+|hypothetical-protein
MSWVERKQFGHIKRSIGHRIGELLVVLYLAEVIQKKGGIMGGGKSELKLLACQRGEQNWSTITAEEVIPSEEANKFSPGSLLLVDLTGNKQVQRVQEAGRPIANILQTFSRLQEKIRTKEEEIEQWNESLTYQSQELTRREMEMEARQEELQQLEIECQQMEQQRQEFQAVREEVMRQQEELERNRQEMAGAWEQLQGQRQQLEERKEELLGACVLDEAKAQELCHMLDRFTESATLPETVRQCNELVDYQQNLLSHHWQILEEQRQLTEQMRQEVGQKADYVAEQWHIWNQAQESLENAKIEIKSQQSVLKSQQEIAQSLTAQIQYHSDLHQHLQTAIAGGGGEVQVDIQELENLPIEELKSIVQSLQGEFDQSSQFVHGQEEELRLKEKEIQELKNRIAQASEFDRMSLENELTDEQDAYEFLNQTLVGQRRSLREKELQLRQHKAVLIRRGGAEADQDSGLDLSIVFAQIEAQRQKQSEELQQVEARIREIESAIQQAQDYVNSQSGEQEAKRNELKQLEEALQSQRVSAAELAGRVALYQEMLQPIQDSITTMRQHLEVIAQSGGQHSAIEDMKRAITELTRKPEFAMA
>NZ_AP018203.1|WP_017290872.1|117460_118432_-|tRNA-lysidine(34)-synthetase-TilS
MASSWTPLHAKIHRTLRSRSLLPKHESILIALSGGQDSLCLAQLLIDLRDRWNWHLAIAHCDHRWRADSQANADHIATLAQSWNLPFYLKTADSPPPNEASAREWRYAQLQSIEGFHTIVTGHTASDRAETLLFNLIRGSGADGLSSLNWTRQLTPTVKLVRPLLEIMRSQTAEFCRDRNLPIWQDSTNNDLAYARNRIRQELLPSLKHNFNAQVESHLAQTMELLSAEVEYLETVASEFYETAIDITSQSLDRTILRKIPLAIQRRVIRQFLMRSLNFNPNFEQVEKCVGLITAPNRSRTDPFIEKTIAEVNADQIQLKSLD
>NZ_AP018203.1|WP_026148973.1|118596_118815_+|DUF433-domain-containing-protein
MSKHSSVISSSPEIMGGTPVFVGTRVPVQTLLDYLKAGESIDDFLDGFPTVSREQVIALLEEAEKQIVRMVA
>NZ_AP018203.1|WP_017290874.1|118816_119137_+|hypothetical-protein
MNLLLDECIDRRLAREFSDYDVKPVPQMGWAGIKDGQLLELAALEFDVFLTVDRNLAFQQNLPAFDIAVIVLQASSNRLADLKPLAPAVLAILPTAMKGQATIVSA
>NZ_AP018203.1|WP_017290875.1|119155_119542_-|hypothetical-protein
MDNGFTPMNDDEVLFVDRGRVLMTNPTFKVSEFLDQLAQAVSDREGEWTEDNEAWFEDGLECEALRFNSGTGWQRGRVRIRLEFAPLKPQERLPERSSARQPDVLQPEPLTDRLRPRNIDDIYSNDDY

Crispr_ID: NZ_AP018203_3

• CRISPR_ID: NZ_AP018203_3
• CRISPR_location: 514366-514476
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_3

Consensus_repeat	Method
CAATAGCGCTTAGTGCAGCGGTTAGTGCCGC	CRISPRCasFinder

spacers of NZ_AP018203_3

>3.1|514397|49|NZ_AP018203|CRISPRCasFinder
GCCAGTGCAGCACGCTGAAATCCAATCAGAGCAAGCGTTACTTCGATTT

CRISPR arrays and Neighbor proteins around NZ_AP018203_3

CRISPR arrays

The CRISPR arrays of NZ_AP018203_3

>merge|NZ_AP018203|3|514366-514476|CRISPRCasFinder
CAATAGCGCTTAGTGCAGCGGTTAGTGCCGCGCCAGTGCAGCACGCTGAAATCCAATCAGAGCAAGCGTTACTTCGATTTCAATAGCGCTTAGTGCAGCGGTTAGTGCCGC

>NZ_AP018203|3|3|514366-514476|CRISPRCasFinder
CAATAGCGCTTAGTGCAGCGGTTAGTGCCGC	GCCAGTGCAGCACGCTGAAATCCAATCAGAGCAAGCGTTACTTCGATTT
CAATAGCGCTTAGTGCAGCGGTTAGTGCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017291271.1|520193_520877_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291263.1|512709_512991_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291255.1|509319_509736_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291277.1|523820_524678_+|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl|CDD|379142
NZ_AP018203.1|WP_017291268.1|515406_515586_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291266.1|513785_514310_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291260.1|511061_511337_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291258.1|510096_510426_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291270.1|519997_520207_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291261.1|511398_512433_-|hypothetical-protein	unknown	unknown	gnl|CDD|212669
NZ_AP018203.1|WP_017291272.1|520880_521390_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291269.1|515588_519857_+|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl|CDD|366703
NZ_AP018203.1|WP_017291276.1|522974_523259_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291256.1|509732_509948_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291253.1|506345_508175_-|hypothetical-protein	unknown	unknown	gnl|CDD|379165
NZ_AP018203.1|WP_017291267.1|514729_515407_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291259.1|510575_511025_-|HNH-endonuclease	unknown	unknown	gnl|CDD|372995
NZ_AP018203.1|WP_017291254.1|508244_509231_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017291273.1|521421_521841_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379233
NZ_AP018203.1|WP_017291274.1|521912_522134_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017291277.1|523820_524678_+|trypsin-like-peptidase-domain-containing-protein	gnl|CDD|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	0.00017781
NZ_AP018203.1|WP_017291253.1|506345_508175_-|hypothetical-protein	gnl|CDD|379165	pfam13401, AAA_22, AAA domain.	0.000258814
NZ_AP018203.1|WP_017291259.1|510575_511025_-|HNH-endonuclease	gnl|CDD|372995	pfam14279, HNH_5, HNH endonuclease. This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.	5.14404e-12
NZ_AP018203.1|WP_017291269.1|515588_519857_+|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	3.62299e-35
NZ_AP018203.1|WP_017291273.1|521421_521841_+|helix-turn-helix-domain-containing-protein	gnl|CDD|379233	pfam13518, HTH_28, Helix-turn-helix domain. This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	4.66828e-05
NZ_AP018203.1|WP_017291261.1|511398_512433_-|hypothetical-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	3.71265e-18

Protein sequences

>NZ_AP018203.1|WP_017291266.1|513785_514310_+|hypothetical-protein
MKPTTEQIQNWFESPQIVQWIASRSPDLGKAILENLPELIANYNPQAKSDWTAKFVLSDGIQRAIGVNRQQWLLWTGTGIAVSPCDFSLQDYLNSLPIPTQDDLRKARLLAEQGFSRGQIYEVLDCNLSPEIEDAIALGHEQSHGKSLYRRAVEDHHFPSIVRILKRFGWRTAG
>NZ_AP018203.1|WP_017291263.1|512709_512991_-|hypothetical-protein
MASMFGAYISRRITFHVDDFDQATATLDYKTIWENIVAFFTAISFVCNWAISTGRKTRNYFNNVLSPWLEGFGISIKSPTLQLPALPATVQLD
>NZ_AP018203.1|WP_017291261.1|511398_512433_-|hypothetical-protein
MNYSPDRAALSLRNKVGYSSKLISIEISNSQGKRYGEGDINPLIVHSAWTHTIDRVARGKGTQSSPQIQTKDGETIWFGEMPALGEHQSIATLGRDKSEMAAFLLMPLLLPEDNGGAHGGHLRIVMSHHSYFDPAVKQRIEDQILGRHQFTRNGREVDVIVDSVELVPEGVGAYWLASELNQLKSGYTLSIEIGYRTVEVWLLDDAGEPIKGEPIQFGVFNLASAISSDDEVRTALLGTTDTPKTVKDTQIAIALKQGKIAKIKDQQWEAIKTRHLERWKDDVIGMIFSQHEAILTQAEQILFSGGGAMLLRERLLKANPNFWVDSDAQTASVRGSYYHFLSLA
>NZ_AP018203.1|WP_017291260.1|511061_511337_-|hypothetical-protein
MSDKSDVDVSFFLEYLINRFGSQAVLEMTNGAVTITSEPIEHKAVSTVPIVESKEPYRPISDPKAALNDTKEHYPPSSETKQSLAQSFRNI
>NZ_AP018203.1|WP_017291259.1|510575_511025_-|HNH-endonuclease
MIKTVIFARELAAIWGCECVYCGSEATSRDHLTPQSLGGVHDLSNLAPCCKSCNSKKGAKTIEDFAGLEKAATIRAIAKEKALIHPNAVYGEGWRKPDRKNTVTLTDTAFVRLQALVDLGEYSSIDDAANYVLMSALTLKQFLRENSAC
>NZ_AP018203.1|WP_017291258.1|510096_510426_-|hypothetical-protein
MKPDLSYYSQPLADALAPTFGDRLEQLFYIEKVQLIGAIGMWISFRIDGEIDDASFSDYVEEFTPINPSFDAWDVATIHTNFRTPDDAMPLLKALVAQLDQRIWMEQEP
>NZ_AP018203.1|WP_017291256.1|509732_509948_-|hypothetical-protein
MIRFPIQCFAISISIGAIIQGCQPISHKPQIEPIKGFEVPADRPAITDSDRIRNNTIRPDEVERIEQRRVK
>NZ_AP018203.1|WP_017291255.1|509319_509736_-|hypothetical-protein
MSLHKQLYKGSRNLGIGLLLFSAVIGGSQLLIKAGKQHETDLRTAEIEQRAQISEKQADAQNREATAFQKADQLNIDRLIINDVGREQIKPGLPFWKTQPTQTRLIFDKFERCAGIWKDRKFTPDTTVCNNPDHPLLK
>NZ_AP018203.1|WP_017291254.1|508244_509231_-|hypothetical-protein
MPIEQRSAYRQGFKRGYRHSQQDAQEDGQENSTTQIGATLMALRTTQGNSNQNKTESPTAQPAKTNHDTNPSPDEIFGSMADCIAWFFSRPAALYKWCTAPRGGQRIFLGSIAIYFWLCSAESYWQALAIGNYFSKTGKFDGSYIAETHPSFMPKPFSPNNGNIQNIGVAFADPNFYVTGIISIVILGVQANLQRGKKSVAKAKQDYESVKNLRVGEVPKDSIDVVKIEARAYKQAGTANHKKISGAVRASYAVDVASAVAPLYRFMFLSPSAFVTCAIWTYINVFAAEKFVALWQANEDIVKTENESKRFPKWLNFRKPAANKSESA
>NZ_AP018203.1|WP_017291253.1|506345_508175_-|hypothetical-protein
MALNKFNPQLMNDDQLLPATLLEMGDTLNFIETRKHTLRNEIKTSKIDAGVGKVSGLAGIAGGSALLILSNPLGGLVVAGSAVAYSMAVFAQWLQTGKLQLMPLSSKTQSERDIELSGSTETGNAYDVAAIQGARDSIREDAAYLSDREKIEYELLHFSPEGLLSAMNHVHPTQRWACYQFLIDAFLARTIQSYFANPQALRDVLGNPAIYTSHLPEASKRFPQYGLQSAGAIEGDAARASFQAPQIGSNTRLNAVEVQHAPMVQSVASTAQKQASEDIAKSLAEHLQSTLIVGQPGAGKGLTIAYATRWIKQLHPECEIWAIDPKSDPAEADYWKMCDRLLQCPIRPFTPAEDMEAIQDAIDNFIAEFQNSHAPMKLLIFDEALAVKEKTGKWFKGLMAGFNALCSMGRSSKQYGWLVSQSPNTDDFGISGGTRNVYRRVLLLAKSNQGLIANRSTFFSGEPTQSQLNETGRVYFDSITNSWGITPVYPDLVRDVPVNSESKSEPKSRRVSLESLMQSTEAEHPIEQFYHSENTVSDGNETDNDELEIRAEIKRFLLANSEGSKPRDLSARARKPVKGMSTDDIKLYLDVMVLEDEIYEVDGSFFANS
>NZ_AP018203.1|WP_017291267.1|514729_515407_+|hypothetical-protein
MSEQTEPTVEQQIEQLTQQYARINLERAYQRHGGQPEKFPEFWERAKKSEIVLTEDHQITIGGRLADFYVGRERKSPEVEEHFFNFADRNAANAESTEAPQTQQGSSPAPRAAATLDVLYVSQTQLNDRRFMRAAGTEILTAIRDGRIAVNDSKAVQDVAEVQKFLAPKQAEPAPTAKPGPAPKRTTQITKAQAMNRNFTRKLEAEWSEQGGYLKNVQNGNIRIV
>NZ_AP018203.1|WP_017291268.1|515406_515586_+|hypothetical-protein
MKEQDLDPGILNAIAHASIQIERLDTGSPEEKRIAVMLCVIHFGIFFGSFVQNYKNIIE
>NZ_AP018203.1|WP_017291269.1|515588_519857_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MSDNSLGRLELELTADASKLRQEIEAAERISKQKAESINASLQSAFSGNFQGKGQQIGDSVVRGIDGRLRDSKGRFVKSTEDAFGNPSQYQSHGRKIGDGISSGIQQSLKASSSALSRVFDGIFQGIGQSIFRAVMSPLSGSFNFIGDSVGQANRIEALTTALKYVSGNSQEAVANMKFLRDASDQLGYSLTALIPGFNSLAASTKGTQLEGQETRNIFYSIVEAGRTLGLSNEQIKNSLLAVSQMAGKNIVSMEELRGQLGESLPSAIQIFARAMGVSVQQFTKMVESGQVGADALTKFSRQINKEMGSAVPAALNTAAAASTNLQNQIEKLQENLGKGLQPATTASAKFLAQTLAEIQNSTAFDALNAEATKFADFLKENPQYAKLLGSALDELLTTGMKALVAEAERLLQYLEKNPDAIKQGIAQIADFGKIVADVVRFCGEVAGNLKTWNEWLRKSNEVLYGSGNLLEGVNKFLDYSKSVLTTWQGIVSTMANATGMSSDLKQTGNERPDSKAAALRDAIMGQESSGDHRAVNTKSGALGLYQIMPDNLPSWSKAAVGREVSPDEFLNDPKLQTKIANHQMATMFRTAMNSSGGNEDIAVRKVASEWYSGQQGLYDDPTPQSYGGESYPSIRDYTLSVLQRYKPIAAKLGNLNQSGNAPQSGGAMSDNSSASGGINTSSRSISTETSKGVSGVDFNAAPPQQQQEKIYPVIGSFPITSGYGNRQHPTRGGIRFHDGIDLGTPIGTPVVSPMDGKVIRSGGTQGKDGEFGGYGRLVEVAFKDGTTAFFAHLSQNLVKVGEQVKAGQILAKTGSSGDGTGPHLHLGASKNGQSIDPSFLLGYKRINSPTQGTAAGSNALTDLQAEQEAAKEARELLAKRRAKDKEATDRARLERDRDLALQRQREDAESESAIAKTRNPELKSQLQNQAQIAQKNRAAEDQIQKAKDDLADLIAARTAKVQDGAEGGIDYSKAIENQKKYIASLESLKSSLSEAPKAEWANKVTESLEKLTKATNEGGDAVFEMANQYENGDSPAIQHIKNLNSINAAYESQKQRINETLKSAKELAAVAPSADLSAIIGRNEANLQRLEEGQRRAIERANALEAKADEERAKQQRIDQISAGGERRNTLASGRLGLLQGQISLGNLIGGDTRDLQREEASLKEALRFEDQIDGLKQLHEQGKISFLTLQDLTRQAEQLNEVNLASINQQFNETREIINDNVLPPFKSFVTEMWQGTKSVGDAFKNMISGLLQNLAQLAVNKLFTSLFGKLFGGIGGEFSGVPDIASPILNFSGGGDVPAISGNSFRSGYGEISAALQREGPNAVLSALTPGEKVLDITEAMQYRRMFPNGIGSVANFAMGGDVGGIAPIAMGGGSGTIINIPVTVGSDSNIDPKAMSEAVRATVNDEIMRQKRQGGQFW
>NZ_AP018203.1|WP_017291270.1|519997_520207_+|hypothetical-protein
MAEQKPAQVPPAVLRLNPEREQALQDQIAQAEAQGDVEFAAFLREIIRASQAEYLKAILNWEGGDNGNT
>NZ_AP018203.1|WP_017291271.1|520193_520877_+|hypothetical-protein
MATHDGVIDDQSFPSFRADMNSLFLALITEFSGNSQPPITYPFQRWVDTSTSPATIKRRNSGNTGWVVVGYGDTTNDGMATANNAALTGVSTAPTASAGTNTTQIANCAFVQSAIANNPSWQTAALINGWTSSTGGGFPTIAYRKLPTGAVVLQGVATKTTPANSVIFTLPTGYRPSATRRFVSMDTVPAVIDIASSGDVSIVFTFTGSGSPPATAFVVLDGIRFEV
>NZ_AP018203.1|WP_017291272.1|520880_521390_+|hypothetical-protein
MITKQVYKFDAEGFLAEPLVMEIPENIEEAIVLGLPHDPETGEFSVPPVPYDCTELHPTPGLYRPKFDGMQWQEGATPEEIAELNPAHADWEQLQARLRGTPLFGKAMLTSAVNAWSLLLFALGTSRNVDDLLFALSVVRAGMPEDFSQTETEELNAILADCGFEISLS
>NZ_AP018203.1|WP_017291273.1|521421_521841_+|helix-turn-helix-domain-containing-protein
MAKRKNITDQQLAVVRALIAGRSYSEIEQELGVPKRTVSRWKAQFSGLLAEHDDAISSTLLEARSESAALVVSALDELGRLLRTAEETQDKLAVVDRIFRAHQILNPPTSPGSVTVTPAEESHGQVVVMLPDNSRGSKS
>NZ_AP018203.1|WP_017291274.1|521912_522134_+|hypothetical-protein
MTFRMSRATALILRELAERIMPMDEFLASQRSACPEPQCDPEDGGKNRDVDDASSLDGAELGICRDSNSAELG
>NZ_AP018203.1|WP_017291276.1|522974_523259_+|hypothetical-protein
MKIKEAVTAEQDMEPPLKFTLAPEGGNFSMSDFKAFHQKGNPNTSISLVEVSPTTQVYSSPVAVELVKQGGMLAALAFICVFVYLLTKLIEASK
>NZ_AP018203.1|WP_017291277.1|523820_524678_+|trypsin-like-peptidase-domain-containing-protein
MRKVNVQNLLSYVPVHITLRFGETNLGVGTAFFYTHEGQDYLITNWHNVSGRDPQNYSLLSKEAGIPDNIVLRLPYLEALEDGTLVIKWLPSALNLYNDKDQTLPAWWEHPQHGSDVDVVAIRIRRPSETKSIPANNEVLDLEKLQFEPGMDVFVLGFPLGISGGGRFPIWKRGSIASEPDAHIDNLPKMYIDTATRQGMSGAPVYAQETGVWVPEGKTLHDFEHVAFGKGYRFLGIYSGRILGSDPLHAQLGIVWKEEAILDIIRSEKTGIPSNELTSKSTEAS

Crispr_ID: NZ_AP018203_4

• CRISPR_ID: NZ_AP018203_4
• CRISPR_location: 1072290-1072543
• CRISPR_type: TypeV-U5
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: c2c5_V-U5

Consensus repeat of NZ_AP018203_4

Consensus_repeat	Method
TGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	CRT
GTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	PILER-CR
ATCAGCCTCCCACGAATAGGTGGGCTGAAAG	CRISPRCasFinder

spacers of NZ_AP018203_4

>4.1|1072328|35|NZ_AP018203|CRT
TCGAGAATGAGTTGGGGAAACCCCACCAATGCTCG
>4.2|1072401|33|NZ_AP018203|CRT
TTGGGATGATCAGCAGCTCAATCAGTACGCCGA
>4.3|1072472|34|NZ_AP018203|CRT
AAAAGATGATGCTTGTTGTGCCAGCTGATCGGAT
>4.4|1072328|36|NZ_AP018203|PILER-CR
TCGAGAATGAGTTGGGGAAACCCCACCAATGCTCGT
>4.5|1072401|34|NZ_AP018203|PILER-CR
TTGGGATGATCAGCAGCTCAATCAGTACGCCGAT
>4.6|1072472|35|NZ_AP018203|PILER-CR
AAAAGATGATGCTTGTTGTGCCAGCTGATCGGATT
>4.7|1072328|42|NZ_AP018203|CRISPRCasFinder
TCGAGAATGAGTTGGGGAAACCCCACCAATGCTCGTGTTGCG
>4.8|1072401|40|NZ_AP018203|CRISPRCasFinder
TTGGGATGATCAGCAGCTCAATCAGTACGCCGATGTTGCG
>4.9|1072472|41|NZ_AP018203|CRISPRCasFinder
AAAAGATGATGCTTGTTGTGCCAGCTGATCGGATTATTGCA

CRISPR arrays and Neighbor proteins around NZ_AP018203_4

CRISPR arrays

The CRISPR arrays of NZ_AP018203_4

>merge|NZ_AP018203|4|1072290-1072543|CRT,PILER-CR,CRISPRCasFinder
AGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAGTCGAGAATGAGTTGGGGAAACCCCACCAATGCTCGTGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAGTTGGGATGATCAGCAGCTCAATCAGTACGCCGATGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAGAAAAGATGATGCTTGTTGTGCCAGCTGATCGGATTATTGCAATCAGCCTCCCACGAATGGGTGGGCTGAAAG

>NZ_AP018203|4|1|1072290-1072543|CRT
AGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	TCGAGAATGAGTTGGGGAAACCCCACCAATGCTCG
TGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	TTGGGATGATCAGCAGCTCAATCAGTACGCCGA
TGTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	AAAAGATGATGCTTGTTGTGCCAGCTGATCGGAT
TATTGCAATCAGCCTCCCACGAATGGGTGGGCTGAAAG

>NZ_AP018203|4|1|1072291-1072543|PILER-CR
GTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	TCGAGAATGAGTTGGGGAAACCCCACCAATGCTCGT
GTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	TTGGGATGATCAGCAGCTCAATCAGTACGCCGAT
GTTGCGATCAGCCTCCCACGAATAGGTGGGCTGAAAG	AAAAGATGATGCTTGTTGTGCCAGCTGATCGGATT
ATTGCAATCAGCCTCCCACGAATGGGTGGGCTGAAAG

>NZ_AP018203|4|4|1072297-1072543|CRISPRCasFinder
ATCAGCCTCCCACGAATAGGTGGGCTGAAAG	TCGAGAATGAGTTGGGGAAACCCCACCAATGCTCGTGTTGCG
ATCAGCCTCCCACGAATAGGTGGGCTGAAAG	TTGGGATGATCAGCAGCTCAATCAGTACGCCGATGTTGCG
ATCAGCCTCCCACGAATAGGTGGGCTGAAAG	AAAAGATGATGCTTGTTGTGCCAGCTGATCGGATTATTGCA
ATCAGCCTCCCACGAATGGGTGGGCTGAAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017285726.1|1081174_1082797_+|radical-SAM-protein	unknown	unknown	gnl|CDD|188475
NZ_AP018203.1|WP_017285707.1|1060707_1063236_+|GTPase-domain-containing-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017285709.1|1065975_1066458_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017285717.1|1073111_1073378_+|DUF3493-domain-containing-protein	unknown	unknown	gnl|CDD|371841
NZ_AP018203.1|WP_026148335.1|1058801_1059638_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_026148336.1|1075248_1076391_+|glutamate--cysteine-ligase	unknown	unknown	gnl|CDD|131103
NZ_AP018203.1|WP_017285721.1|1076822_1077722_-|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl|CDD|376459
NZ_AP018203.1|WP_017285704.1|1057933_1058812_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_026148338.1|1082922_1083471_+|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|368559
NZ_AP018203.1|WP_017285725.1|1080581_1081100_+|DUF4330-domain-containing-protein	unknown	unknown	gnl|CDD|379510
NZ_AP018203.1|WP_017285723.1|1078661_1079414_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|277316
NZ_AP018203.1|WP_017285710.1|1066743_1067142_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017285715.1|1070971_1071712_+|hypothetical-protein	c2c5_V-U5	-	gnl|CDD|273793
NZ_AP018203.1|WP_017285706.1|1059662_1060394_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017285712.1|1068674_1068911_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017285722.1|1077795_1078518_+|DUF1995-family-protein	unknown	unknown	gnl|CDD|370448
NZ_AP018203.1|WP_017285724.1|1079571_1080318_-|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320692
NZ_AP018203.1|WP_017285708.1|1063232_1065881_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017285711.1|1067296_1068574_-|IS5-family-transposase	unknown	unknown	gnl|CDD|377531
NZ_AP018203.1|WP_017285718.1|1073391_1074996_-|DUF1565-domain-containing-protein	unknown	unknown	gnl|CDD|284923

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP018203.1|WP_017285715.1|1070971_1071712_+|hypothetical-protein	c2c5_V-U5	-	1.3e-88	292.6	4.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017285726.1|1081174_1082797_+|radical-SAM-protein	gnl|CDD|188475	TIGR03960, radical_SAM_domain_protein, radical SAM family uncharacterized protein. This model describes a radical SAM protein, or protein region, regularly found paired with or fused to a region described by TIGR03936. PSI-BLAST analysis of TIGR03936 suggests a relationship to the tRNA pseudouridine synthase TruA, suggesting that this system may act in RNA modification. [Unknown function, Enzymes of unknown specificity].	5.02547e-88
NZ_AP018203.1|WP_017285717.1|1073111_1073378_+|DUF3493-domain-containing-protein	gnl|CDD|371841	pfam11998, DUF3493, Protein of unknown function (DUF3493). This family of proteins is functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 79 to 331 amino acids in length.	4.43587e-31
NZ_AP018203.1|WP_026148336.1|1075248_1076391_+|glutamate--cysteine-ligase	gnl|CDD|131103	TIGR02048, gshA_cyano, glutamate--cysteine ligase, cyanobacterial, putative. This family consists of proteins believed (see Copley SD, Dhillon JK, 2002) to be the glutamate--cysteine ligases of several cyanobacteria, which are known to make glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NZ_AP018203.1|WP_017285721.1|1076822_1077722_-|class-II-fructose-bisphosphate-aldolase	gnl|CDD|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	1.83425e-125
NZ_AP018203.1|WP_017285718.1|1073391_1074996_-|DUF1565-domain-containing-protein	gnl|CDD|284923	pfam07602, DUF1565, Protein of unknown function (DUF1565). These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterized domains such as pfam00395 and pfam03422.	4.44322e-34
NZ_AP018203.1|WP_026148338.1|1082922_1083471_+|Uma2-family-endonuclease	gnl|CDD|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	4.12911e-31
NZ_AP018203.1|WP_017285715.1|1070971_1071712_+|hypothetical-protein	gnl|CDD|273793	TIGR01766, Putative_transposase_MJ0751, transposase, IS605 OrfB family, central region. This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions].	0.00712227
NZ_AP018203.1|WP_017285722.1|1077795_1078518_+|DUF1995-family-protein	gnl|CDD|370448	pfam09353, DUF1995, Domain of unknown function (DUF1995). This family of proteins are functionally uncharacterized.	3.4496e-81
NZ_AP018203.1|WP_017285724.1|1079571_1080318_-|M48-family-metalloprotease	gnl|CDD|320692	cd07333, M48C_bepA_like, Peptidase M48C Ste24p bepA-like, integral membrane protein. This family contains peptidase M48C Ste24p protease bepA (formerly yfgC)-like proteins considered to be putative metallopeptidases, containing a zinc-binding motif, HEXXH, and a COOH-terminal ER retrieval signal (KKXX). They proteolytically remove the C-terminal three residues of farnesylated proteins. They are integral membrane proteins associated with the endoplasmic reticulum and golgi, binding one zinc ion per subunit. In eukaryotes, Ste24p is required for the first NH2-terminal proteolytic processing event within the a-factor precursor, which takes place after COOH-terminal CAAX modification (C is cysteine; A is usually aliphatic; X is one of several amino acids) is complete. Mutation studies have shown that the HEXXH protease motif, which is extracellular but adjacent to a transmembrane domain and therefore close to the membrane surface, is critical for Ste24p activity. Several members of this family also contain tetratricopeptide (TPR) repeat motifs, which are involved in a variety of functions including protein-protein interactions. BepA has been shown to possess protease activity and is responsible for the degradation of incorrectly folded LptD, an essential outer-membrane protein (OMP) involved in OM transport and assembly of lipopolysaccharide. Overexpression of the bepA protease causes abnormal biofilm architecture.	2.41521e-80
NZ_AP018203.1|WP_017285723.1|1078661_1079414_+|serine/threonine-protein-phosphatase	gnl|CDD|277316	cd00144, MPP_PPP_family, phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain. The PPP (phosphoprotein phosphatase) family is one of two known protein phosphatase families specific for serine and threonine. This family includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.2722e-21
NZ_AP018203.1|WP_017285711.1|1067296_1068574_-|IS5-family-transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	5.78842e-16
NZ_AP018203.1|WP_017285725.1|1080581_1081100_+|DUF4330-domain-containing-protein	gnl|CDD|379510	pfam14221, DUF4330, Domain of unknown function (DUF4330). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 165 and 177 amino acids in length. There is a single completely conserved residue G that may be functionally important.	3.39087e-57

Protein sequences

>NZ_AP018203.1|WP_017285715.1|1070971_1071712_+|hypothetical-protein
MSAEGTLEAQQEKVAKTLKKLTHPNPDPRNHSTLDRLQNLPERPSRTPYVGNPEILVGISIGLADPITVAVVNGRTGEILAYRTPRALLGEQYHLLNRHRKEQQHRLQRHKNQQRGVAYQPSESELGQYVDQLLANSTIDLARTYQAGSIVVPNLKNVRDLLASEIQARAEQKCPGSVAAQKQYAKAYRQAIHQWSYNRLIQAICSQATQRGITVEVGSQPLKGNPQELAKDIAIAAYYARAITAK
>NZ_AP018203.1|WP_017285712.1|1068674_1068911_-|hypothetical-protein
MEVSDAGCRVFHNSFRDFIRAELSPEQLQRLDQSILFSYLDKQRNQLLWFMYAHRYAEAAKAYSYLMTSYEQGYISRP
>NZ_AP018203.1|WP_017285711.1|1067296_1068574_-|IS5-family-transposase
MTGFSKTPSGKSSSEAPKLKAQLNAQHALFKLANLLDWESLEQDFGTTMTTDGGRPPLPVRLMVGLHYLKALYNESDESVVAKWVENPYWQYFCGEETFQHQLPCHPSSLGNWRRRVGVDGLEKLLSQVIKTAMQCEALSPQDVKQVIVDTTVQEKAIAFPTDARLYDKARRTLVRMARKHQVKLRQTYVRVGKQVLLKQSRYAAARQGRRAQKQTRILRTYLGRVIRDLERKLKPMPEAVAVLLKSAKRIYQQQKQDKGKCYSIHAPEVECIAKGKAHKPYEFGCKVVLTTTNASNWIVGIAAQHGNPYDGSTLTPAIEQVERLTDIRPNHATVDQGFRGKDHHPQDVEVLVCDTRKRTGKARRLFKRRSAIEPVIGHSKSDHCLGRNYLKGQLGDSLNALLAGCGFNLRKLFRAVMVLEVEPA
>NZ_AP018203.1|WP_017285710.1|1066743_1067142_+|hypothetical-protein
MYRREIRYTCRGDMQMLFSMNPRICASCPVKQHCLSDDSKNTKGRRISVIRMKLPPIPAVVLEPEITVIAQTPIQTVQGTQALIWTDIPATQLRREIRQHLRRHQTRIEQSHSATQPVESAIVYLTRSQRAY
>NZ_AP018203.1|WP_017285709.1|1065975_1066458_-|hypothetical-protein
MEPLSLLAGAVTTYIIPKALEKVGEKVGEVALTKGSEMVQATRDAVQNKLKSTNTDGVLAIAEADPTEANLEMLETILLSQMKSDPDFATLLRDFVNRIQSQSPMLQVVLDSVRIKNSVEIGNIEQISEGSAAEQVVGRNLGVGGDLKIGDIRQSVHRKL
>NZ_AP018203.1|WP_017285708.1|1063232_1065881_-|hypothetical-protein
MSQPNLEQSIFEDVDVGGDFTVGDITQIGSQTVIQQKPDFFEPALDRYKPSTFKSPNLISQLLTRLTNQRFLVLAGSSDVDKDSLAKHTAACLIESLSAQRMEAISKEWYRSSDPQSIDIELQNTEKTTVFILTQVNPQSFGYDLARIQKAANLCKHYIVMSTDVTFAAWRQPSSTKLFWYELSRGSVADAPQLINTLSQEEALSNWYHHHLKQPRDRLLALGLSFFDGLFDDQFFAALEEIVERVWQRRDASLRALDYRDLENLHTFFNFTETKNQGTKIAIRFPKQRRTLFKIAWHSDRRQILSALPVLVDLIRQSVVGRLANLELYGSDTKCKEIRTVIAETISDIGSISENAIQTTLLQLSADPNTDVQATAAYAMARWRDPEYSLDQQLFKTLHSWLDLMQARHIIAQVEAILRGRNSESSKSSKAEDYIKITVALTISYAALYDAPRGMEGSTGLSQECCDLLEKLATDPSPVVRDVFLSYTLPRALQIHLRQLRQWLQDKIQQQVSPTHSHSAIINFNQAIAASLAGTYRRDSEATIKILEHWEDEGRKRLSEVIDPAKVTSRESLLATVARTYGEIEPQPELGQLTASSIVDRLQQMLQGEKHPFVREAILFALCRQARSHFDEIEFQLQSLVANLQESEWQEIADLLSDIYVEQRVQLSGGDYWSAKPIQIGNYSYRYQIWTKQARPQTQIEEAMYHSWLTSESNPAAQQIALRAANAFADRVDRDEEQEQQRILNNLDREQTAIVPQPKQMPTRSTYNPLVKHFVPWLAVFLKWLQYGLFKRIYCNALTGRWSYYQNTVSNILPEALKQDLSSRFTMAFVIGRLRGLGSRDVQIIVDLLDLSIVIAKNPGSVVIIGLLLVGGLGWLLTLFGR
>NZ_AP018203.1|WP_017285707.1|1060707_1063236_+|GTPase-domain-containing-protein
MSRAEKIEQIIAKRQPLVAIVESNKANLITLSTSLESLQERCSQLLTHRTEVEISKGLRKKLDELRSEIATAIADLDRLMVRFKRPTLNIGVIGRARQGKSRLLRSLTGLSEVEIPDSRGEFCTGARSKILHSDSTESATGQAYFYSEQDFLQEVIHPYYTNLSLGELPATLDALKEIPALPENKQTLSGRALYGHLRKTYVKQLDDYRPLFLKGDIPITAAEIRDYVTQDQTNDQGKPILNYLAVREVVITCRFPQADIGKIALVDLPGIGDINYVDEERLTNTLRQDVDFVLFVRMPGSKGDSLQDFDVQLYEKARESLKELPIQLWSMMVLNWVKGDEKTDNFHLCEKYISRMDEFNIEVSDRVIADCDDSREAQTKVLDPVLDYLAHEIEALDKQYAQSCQAQLDQLQRKVLVELEKASTILVQADLYQIFQENFETFWKRDLPGALEDFIIDKSRKRKDSEAQFKAKVANVIKKCQTETRLPSSVDVKITRDYHESFNTAYNSYLPRLRADLARQFLSLDGQFQDYLETVKSELTDVLVKKAKLKGLSSAKGSQFFQDVLERIRAVPGAEAQFREIQLGFETLSVFNVSYAGIIQRQVRAYLDKLTPDESEVADLKPITSSQIHEQVLEIVKSASPEAVKGLTFDHCLEVIKQAFPEPSPVPSNPSGETIAFTLSHFLKSSDVLVLWQLPVVKMMIEFGLERLKSAIAQSPEVLPSPRVIHSELLEKDPDVDRKLPIEQIEATLKLLRDRTIDGCDAVLQQMLHEPNEVAYVMVREFVDRVLRAESAEREWNRFLHREQIHVWEELRQIETRANQQQEWQKLVDAAKHHASNLKVIA
>NZ_AP018203.1|WP_017285706.1|1059662_1060394_-|hypothetical-protein
MAIVYIGDRKAGKTHLALELINPRGHYVKVSGIDYDSLKANLFGTEDTIRATDSIREHPLEVNVQLPIPKPLLVKWMDTPGEIWRSSWQTDNQEDWLSFLGTVTQSEGVLLILPPYREILKPTIDPQPYMTQRQWCNRFDSWVEFFISHCAKARHIAICLNKADLFCDYEAEAQKLIYNPNGRQMAWLDRHRYVSQRYFHPIQAQIDRINTQRDCAARCFITSIHSRTLLELPWIYLASFLSA
>NZ_AP018203.1|WP_026148335.1|1058801_1059638_-|hypothetical-protein
MSKPGQHNQIITIIGSRRTGKTTFMAGLAYWHRQFKSQRFTIDPVGEDTHKLADKAENMICQGLSLDPTLPTDNIDELPEYSFDIWIKQPFKKERIVLVARDYPGEVFDSINGADSLHSDYIDECFQQRVGGCLILLDRWDDDAYYVPRIQKFVQLLHDYGRADLRVAIAISKCERGEIWPCRLDPKRDLFETHLPRTTEILKKGIAKTKLQFFAISTFGVLDPITNPRPNRRDEIVFHEEFGEQRFCYLRERKVWQPYGLMAPIYWLAKEARMSSGH
>NZ_AP018203.1|WP_017285704.1|1057933_1058812_-|hypothetical-protein
MVTKFGKKESQIQNATLRVIGDRAAGKTTYMAALARSIIPPNSPVQSVTPFGEDSKSLVAMAQNVLEQGLEPEPSPLDSTLDLKDYGLTITLRDQFGWSFQGARTTTLNIACKDYPGEFLRDLIFKPESLRFQDYLEDCVRANGLLLLLDGTAYRKDKDYATSVEQLLLALDQENRGASRQRIAIALSKCEQPELWVHRFQPQKAVHDRFPKLCAKLATWQQDGAIQTECFTLSAYGSLGTYTPEPNMRKTYRDQGGTRAVLKNPRLWQPFGLVAPLYWLCTNKRHPGLDKE
>NZ_AP018203.1|WP_017285717.1|1073111_1073378_+|DUF3493-domain-containing-protein
MSQQSERLRQSDPEKYARLKAEAAAPYRGLRKFIYIAFGGSGAIGAFVFLAQTLAGRDLETALPNLALQLGVIALMVWLFRFENRSSK
>NZ_AP018203.1|WP_017285718.1|1073391_1074996_-|DUF1565-domain-containing-protein
MTRLGTSKILAIAPLGLISLLWLGGQTALKAQVTPPPETLTVPLNTVGTTILYVNPARGTDQTTAGRTEAVPFKTLKFALDQATAGTIVQLAPGTYNLQSGEVFPLIVKAGVTVRGDEATKGQSTIIQGGGDIISRSFAKQNVSMWLAQGSQVRGVTVTNENSRGTGIWVEEGSPTISNNTFANSVREGVFITGNASPTVTDNVFVKNQGNGISITRAASGQVKNNSFTETGFGLAINGTATALIEGNQIVKNRGGFVIGDSAKPVLRGNMIADSSEDGIVVLSSAQPDLGTPESLGNNTIRNSKGRDINNTTQNVLTAIGNQLDQKKIAGLINFAPGGAIAFSDVQGHWAQQYVQALASRGIITGFPDGTFKPNDPVTRAQFAAIVLKAFAPAPKNAAVNFSDVSSRYWGFAAIQSAARGGFMAGFPGGTFRPEQRIPKVQSLVALSNGLEFGAGDPSLLSRFQDAASIPTWARSPIAAATQRQIVVNYPTVGQFNPNRDATRAEVAAFIYQALVSAGKAEAISSPYVVGVAR
>NZ_AP018203.1|WP_026148336.1|1075248_1076391_+|glutamate--cysteine-ligase
MMLSKGFEIEVYTGTPQGDVVGMSDEIVAALDGFVREPDSRNVEYTTPPCFRYERSLCDLVTPRLRLRQFLKSKGDYTLIPGSTLPLAGQGDRFWRSDPANPYHDYIEKTYGTKVVTASVHINIGISDPEVLMRACRLVRMEAPLYLALSAASPWFNGEMTGYHSTRWGLFPKTPAHVPIFESHAHFIRWTEEQIAIGTMQNVRHLWSAVRPNGDRRPYNLNRLELRICDLVSDPIALLAVTALLEARLQQLIADPSLDPLQQSKLNAEDLVEIANENEAAAAKSSLDAELRHWQDGQPILAREWIEQLYAETFAIAKKAGFSCFLLPVKKILREGNEAQRWIKLSEQGLNNREILVQSIQAMQLREKELEGQICQSLVA
>NZ_AP018203.1|WP_017285721.1|1076822_1077722_-|class-II-fructose-bisphosphate-aldolase
MLTSTRELLETARRNIFAIGAFNVYNLEGVKAVINAAEISRSPAMLQLHPSALKYGSSPLVALCLEAAEAATVPISVHLDHSTSVKDIDRVLQDGVRSIMADGSPLPYEQNLEFTRNMTRLAHSYHAIVEAEIGRISGTEDGLTIAEKEAKMTDPQQAVEFVKATNVDALAVTIGNVHGEYKSPPRLDFPRLEQIRMLLDIPLVLHGASGLPAEMIARSIQLGVCKFNVNTEVRQAYMQALKDEICGQQEKDLLEVTGEAIAAMQDVILEKLELFGSVGKAHLHETPYATVLAAAAHRN
>NZ_AP018203.1|WP_017285722.1|1077795_1078518_+|DUF1995-family-protein
MPELPDTLEDAIAQAQIATQAALEAGYTRLQVELVFPELKPMPIAEQFITMFRDRGAGLKLFFTDSGIAALAKRDWGDLPHQIRSLDVAGSRQTTPVTEQVDPEDELYVFVSPSAVEVPPVEQICNAAGERPVILLNPRLEDVATIGIGYAGRQLRQRFLDTIEPCYYLRPLDDQSAIFRCYPSPWQVWYAPDGTYELIAEERDRPDSEKLDEIFAKALGQSAKPSLFAGLQQFIKALGR
>NZ_AP018203.1|WP_017285723.1|1078661_1079414_+|serine/threonine-protein-phosphatase
MSQQPTRRIVIGDVHGHYDGLMNLLDTIAPEASDQVYFLGDLIDRGPQSYQVIEFVKNSPYQSLLGNHEHLLLEAFPNGQVYAPALQAWLQSGGRATVASYTDMDVLVEHVQWIRTLPTYLDLGDVWLVHAGVHPEMPLEQQGYAEFCWIRDEFHRSTQPYFSDKVIITGHTITFTFQGVVPGAIARGQGWLGIDTGAYHPKSGWLTALDIDNAIVHQANMYTNQVRTLGLDEVTTAIEPKPRGRQVLKR
>NZ_AP018203.1|WP_017285724.1|1079571_1080318_-|M48-family-metalloprotease
MLAQAISWTDLLRGGIQIIQANQLSRLSDSQEVDYGRQINNQLTTQEVRLVNDPKLTAYVNEIGQRLAANSDRPNIPYTFQVVDQKSINAFATMGGFVYVHRGLLDAADNEAQVASVIGHEIGHIAGKHALNQMRQTAVQRGLLAAGGLDRSTIANLGVQVALRLPNSRRDEYDADARGVRMMGRAGYAQSEAVTFMRKLLNSASPPTFLANHPATSDRITRMQQLIRQNPGSGTAGLDPASYRARLR
>NZ_AP018203.1|WP_017285725.1|1080581_1081100_+|DUF4330-domain-containing-protein
MAIVDSQGRLFGKISILDVGAALVILLVVVGIFVYPGPTGAGAQGARQPVEVDVVVRGLSASNPKSFIKVGDTTNILVRKQPSGSVKLKELRFLPRTVATPQPDGTLKVFPDPRPELALTNDMLMTLTNEVPIVDGTPVLGGEKVKVGTTIELDGPTYTFGTTVVAIRINKS
>NZ_AP018203.1|WP_017285726.1|1081174_1082797_+|radical-SAM-protein
MTSPFSSERLLFTPATPQADAIPLIFAFPNEYSVDITSLGYQVVWATLAARSDLDVARLFTDIHEPLPANPELLGFSMSWELDYVNILGVLESLEIPIWSRERSHSHPIVFGGGPVLTANPEPYAEFFDVFLLGDGEILLDAFVHAYQEVRHADRDTQLKHLARVPGIYVPSMYQVTYQSPDGAIASITPIDATIPAQVQKQTYRGNTLSASSVVTEKAAWENIFMVEVVRSCPEMCRFCLASYLTLPFRVADVEDSLIPAIEQGLTVTNRLGLLGASVTQHPEFESLLDHLNQHRFDDVRISLSSVRTNTVTEKLTRTLVKHDAKSITIAVESGSDRVRKIVNKKLETDEIVQAAVNAKAGGLNSLKLYGMVGIPGEESADVEQTVAMMRSLKKAAPGLRLTLGCSTFVPKSHTPFQWFGVNPQAEKRLQSLQKQLRSNGIDFRPESYNWSVIQALLSRGDRRLSKLLELTRHYGDSLGSYRRAFKELKGQLPDLNDYVFDRWTVDRVLPWSHLQGALPQSTLEKHMASSFPEPLAVGH
>NZ_AP018203.1|WP_026148338.1|1082922_1083471_+|Uma2-family-endonuclease
MIVLPHLKWTIEEYHRLIEQGFLADKKVELLRGEIIEMAPESPDHADSNSEAHAYLLLLLGDRAKVRNAKPITLPNGSEPEPDISVCERREYRSHHPYPENIFWLIEYSDSTLKKDLEIKSKIYAEAGIQEYWIVSIQTHELIVMRDPEGGEYETEFRVKSGTLNPLAFPEFEIDVLRIINP

Crispr_ID: NZ_AP018203_5

• CRISPR_ID: NZ_AP018203_5
• CRISPR_location: 2090493-2090732
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_AP018203_5

Consensus_repeat	Method
ATTTGCGCCGCGTAAATCCGCCCC	CRISPRCasFinder

spacers of NZ_AP018203_5

>5.1|2090517|21|NZ_AP018203|CRISPRCasFinder
ACTCAGATTTGCGCCGCGTAA
>5.2|2090562|42|NZ_AP018203|CRISPRCasFinder
GCGTAGCGTTGCGCCTTCATAAGCGCGTTTCTCCTCTCTAAA
>5.3|2090628|21|NZ_AP018203|CRISPRCasFinder
GCGCAAGTCGGCTCCGCTAAA
>5.4|2090673|36|NZ_AP018203|CRISPRCasFinder
ACTAAAATTTGCATCTAATGCGATCGCGAGTGAAAG

CRISPR arrays and Neighbor proteins around NZ_AP018203_5

CRISPR arrays

The CRISPR arrays of NZ_AP018203_5

>merge|NZ_AP018203|5|2090493-2090732|CRISPRCasFinder
ATTGGCGCGACTTAAATCCGCTCCACTCAGATTTGCGCCGCGTAAATCCGCCCCACGTAAATCGGCTCCGCGTAGCGTTGCGCCTTCATAAGCGCGTTTCTCCTCTCTAAAATTTGCGCCGCGTAAATCCGCCCCGCGCAAGTCGGCTCCGCTAAAATTTGCATTTCGCAAATCCGCTCCACTAAAATTTGCATCTAATGCGATCGCGAGTGAAAGGTCAGCCCCACGCAAATCCGCTCC

>NZ_AP018203|5|5|2090493-2090732|CRISPRCasFinder
ATTGGCGCGACTTAAATCCGCTCC	ACTCAGATTTGCGCCGCGTAA
ATCCGCCCCACGTAAATCGGCTCC	GCGTAGCGTTGCGCCTTCATAAGCGCGTTTCTCCTCTCTAAA
ATTTGCGCCGCGTAAATCCGCCCC	GCGCAAGTCGGCTCCGCTAAA
ATTTGCATTTCGCAAATCCGCTCC	ACTAAAATTTGCATCTAATGCGATCGCGAGTGAAAG
GTCAGCCCCACGCAAATCCGCTCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017286657.1|2087011_2087665_+|urease-accessory-protein-UreF	unknown	unknown	gnl|CDD|223900
NZ_AP018203.1|WP_017286665.1|2094121_2094706_+|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_AP018203.1|WP_017286649.1|2080671_2082006_-|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl|CDD|236426
NZ_AP018203.1|WP_017286664.1|2092975_2094055_+|DUF3326-domain-containing-protein	unknown	unknown	gnl|CDD|371736
NZ_AP018203.1|WP_017286659.1|2089440_2089851_+|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl|CDD|214351
NZ_AP018203.1|WP_017286662.1|2092501_2092822_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl|CDD|273926
NZ_AP018203.1|WP_017286661.1|2091057_2092053_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_026148451.1|2096453_2096864_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|381090
NZ_AP018203.1|WP_017286655.1|2085542_2086541_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_AP018203.1|WP_017286658.1|2087906_2089358_+|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl|CDD|214349
NZ_AP018203.1|WP_017286654.1|2084798_2085515_+|ribonuclease-III	unknown	unknown	gnl|CDD|223644
NZ_AP018203.1|WP_017286671.1|2099196_2099487_-|TMEM165/GDT1-family-protein	unknown	unknown	gnl|CDD|225030
NZ_AP018203.1|WP_017286652.1|2082692_2083376_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017286669.1|2097558_2098119_-|DUF2808-domain-containing-protein	unknown	unknown	gnl|CDD|371328
NZ_AP018203.1|WP_017286668.1|2096965_2097388_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017286670.1|2098615_2099086_+|DUF4149-domain-containing-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017286666.1|2095268_2096258_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|235640
NZ_AP018203.1|WP_017286653.1|2084130_2084739_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017286656.1|2086596_2087028_+|urease-accessory-protein-UreE	unknown	unknown	gnl|CDD|237322
NZ_AP018203.1|WP_017286650.1|2082171_2082405_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017286657.1|2087011_2087665_+|urease-accessory-protein-UreF	gnl|CDD|223900	COG0830, UreF, Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones].	8.423e-75
NZ_AP018203.1|WP_017286665.1|2094121_2094706_+|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.6583e-14
NZ_AP018203.1|WP_026148451.1|2096453_2096864_+|response-regulator-transcription-factor	gnl|CDD|381090	cd17535, REC_NarL-like, phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators. The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	7.7575e-30
NZ_AP018203.1|WP_017286659.1|2089440_2089851_+|F0F1-ATP-synthase-subunit-epsilon	gnl|CDD|214351	CHL00063, atpE, ATP synthase CF1 epsilon subunit.	4.51155e-64
NZ_AP018203.1|WP_017286662.1|2092501_2092822_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl|CDD|273926	TIGR02008, Ferredoxin_root_R-B1, ferredoxin [2Fe-2S]. This model represents single domain 2Fe-2S (also called plant type) ferredoxins. In general, these occur as a single domain proteins or with a chloroplast transit peptide. Species tend to be photosynthetic, but several forms may occur in one species and individually may not be associated with photocynthesis. Halobacterial forms differ somewhat in architecture; they score between trusted and noise cutoffs. Sequences scoring below the noise cutoff tend to be ferredoxin-related domains of larger proteins.	1.37985e-26
NZ_AP018203.1|WP_017286655.1|2085542_2086541_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	9.97091e-53
NZ_AP018203.1|WP_017286658.1|2087906_2089358_+|F0F1-ATP-synthase-subunit-beta	gnl|CDD|214349	CHL00060, atpB, ATP synthase CF1 beta subunit.	0
NZ_AP018203.1|WP_017286654.1|2084798_2085515_+|ribonuclease-III	gnl|CDD|223644	COG0571, Rnc, dsRNA-specific ribonuclease [Transcription].	4.44687e-63
NZ_AP018203.1|WP_017286669.1|2097558_2098119_-|DUF2808-domain-containing-protein	gnl|CDD|371328	pfam10989, DUF2808, Protein of unknown function (DUF2808). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	7.95997e-59
NZ_AP018203.1|WP_017286671.1|2099196_2099487_-|TMEM165/GDT1-family-protein	gnl|CDD|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	2.68526e-20
NZ_AP018203.1|WP_017286666.1|2095268_2096258_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	9.75358e-128
NZ_AP018203.1|WP_017286649.1|2080671_2082006_-|nicotinate-phosphoribosyltransferase	gnl|CDD|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NZ_AP018203.1|WP_017286656.1|2086596_2087028_+|urease-accessory-protein-UreE	gnl|CDD|237322	PRK13261, ureE, urease accessory protein UreE; Provisional.	3.31953e-49
NZ_AP018203.1|WP_017286664.1|2092975_2094055_+|DUF3326-domain-containing-protein	gnl|CDD|371736	pfam11805, DUF3326, Protein of unknown function (DUF3326). This protein is functionally uncharacterized. It is about 300-500 amino acids in length. This family is found in plants and bacteria.	0

Protein sequences

>NZ_AP018203.1|WP_017286659.1|2089440_2089851_+|F0F1-ATP-synthase-subunit-epsilon
MALTVRVIAPDKTVWDSSAEEVILPSTTGQLGILTGHAPLLTALETGVLRVRAEKNWVPIAVMGGFAEVEKNEVTILVNGAERGEDIDRTAAQTAYADAQTKFAQAEQGGSKEDQLKATQALKRARARLQAAGGQV
>NZ_AP018203.1|WP_017286658.1|2087906_2089358_+|F0F1-ATP-synthase-subunit-beta
MVTTAEKTNIGYITQIIGPVLDVRFPGGKMPRIYNALSISGQTESGQHVSVTCEVQQLLGDNQVRAVAMSSTDGLVRGMEVADLGAPISVPVGTATLGRIFNVLGEPVDNQGPVNNTETSPIHRPAPKLTELETKPSVFETGIKVIDLLTPYRRGGKIGLFGGAGVGKTVIMMELINNIATNHGGVSVFAGVGERTREGNDLYNEMIESGVIKKDNLNESKIALVYGQMNEPPGARMRVGLSGLTMAEYFRDVNKQDVLLFVDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGDLQERITSTTEGSITSIQAVYVPADDLTDPAPATTFAHLDGTTVLSRGLAAKGIYPAVDPLDSTSTMLQPSIVGNDHYDTARAVQSTLQRYKELQDIIAILGLDELSEDDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVTLEKTIAGFKKILAGELDDLPEQAFYLVGDIDEAIAKAEKMKAG
>NZ_AP018203.1|WP_017286657.1|2087011_2087665_+|urease-accessory-protein-UreF
MDTLTKLLQLASPALPVGAYSYSEGLETLVHSGVIHDVDALEHWIIQELNYGAVRLEAAMMLRSYRATLNQEFDRVLEWNQWFTAARETEELRSQSLQMGGSLLRLFRALYPEPIPNFPDGCNFAIAFGLVAALWEIEESSALLAYLHSWATNLVSAGVKLIPLGQTSGQKLLLKLGEEMGKSTIADLSDDELETCGWGFAIASMSHETLYSRLFRS
>NZ_AP018203.1|WP_017286656.1|2086596_2087028_+|urease-accessory-protein-UreE
MTPTFVRRIPPQSSPDYILSLTAEERTRSRFLFQSDDGQEVYLNLPRGTTLKDGDWLESDQGKFAKIQAKPEPVLTITTSQSLDLLQAAYHLGNRHVPLEISSAYLRLSPDPVLQDLLEHRGLQVKSEIVPFQPESGAYGHSH
>NZ_AP018203.1|WP_017286655.1|2085542_2086541_+|Gfo/Idh/MocA-family-oxidoreductase
MSEQTAIALLGVGRWGAHLLRNFLHNPRARVVAVVDPCLEQLEAIAKRFELDVFCTTQWQDVLEMNGLDAVAITTPATTHNSLITAALKQDLHVLAAKPLTLSFAESVQLCRLAEQQQRQLVIDHTYLFHPAVLRGRELVQSGKLGPLRYGYSTRSHLSPVRSDVDAMWDLAIHDIAILNFWLGETPCQVEAKGSTWLQAGLADTVWATLTYPSGFEARLHLSWLNPDKQRRSCLVGENGSLIFDELAQDQLTVQWGKFDEKFRPIAQSREILDLQNQEPLQQVCNHFLDCVQHNRTSAISSGWLGAGLVQTLVALSESMQANGKAIDILKI
>NZ_AP018203.1|WP_017286654.1|2084798_2085515_+|ribonuclease-III
MSLAYPRRQQELHALAQRLGLSKLDAIDWNLMDLALIHITFSAERNYEQLEFVGDAVVKLAAAEFLLKTYPDLKVGEFTAIRSVLVSDRILAKIADSFGFDRYLLVASSAKSDPAGRDSRLADSLEAVLAALYLSTHNLSLIHPWLDEQFHPLAEEILADPARQNYKAALQNWTQGHQKTLPEYRTQEMGNTHNDPNRFVSEVWIQGRCMGQGTGRSRKAAEQAAAQEAFLVLSGQET
>NZ_AP018203.1|WP_017286653.1|2084130_2084739_+|hypothetical-protein
MKSQASTLELPKHSEVCPSSESLLAISEHKKSGLILCKQYHAEFAGPGAAVNCGVEPIYRAVIAIGSPELIPTQTFDERRRAYGRRIQWGRWLQKIVEHPDPMMRAEKLLAGFEEFFGRQVVIGLPSEVLALLAGVFPGTIEQVRVQHWRGSRTGTMSFLPGSDQLKVTTISMNRHETPEVPLLTSATVSEIERTYAVLKSA
>NZ_AP018203.1|WP_017286652.1|2082692_2083376_+|hypothetical-protein
MTELDFVLLTTYFLCVTYVLYQIVNSFNDEVMVWLDDDDLKQQLADQNLTDAIGISFKFNSRYEYHNLEKLQIRINNKTKDRALYVDWDYCALTEQYDKRSRRVTRSVPGEPTDLFQRQVFSVIAPGKTLFEDIFAEDMMARKDGTIKASKTLLDFSEPNKKAPEAKKKLYKNFVNSKEPFQFDLDLVLRFIGFGTSPTGDRIRLVCRFNVRKLDWTAGLPWNPKMP
>NZ_AP018203.1|WP_017286650.1|2082171_2082405_-|hypothetical-protein
MKSPLKFLGQPIQWVNDLLLSQLSGFQEKMTSDRINLLERTGFFRCFLKLCILVSNSNTNGEGEQARSRQFLYKSRG
>NZ_AP018203.1|WP_017286649.1|2080671_2082006_-|nicotinate-phosphoribosyltransferase
MEDLKLTIQPEDYSLLTDLYQLTMSACYVGEGLDQRRASFELSARRLPKGFGYAIAMGLAQALDYLESFRFSLDQISALQATGIFDDAPAEFWTVLETACFEGDVWAVPEGTAIFANEPFLRVEASLWQAQLVETYLLNVINYQTLVATRAARLRDIAGKDATLLEFGTRRAFSPQASVWAARAALAGGLDATSNVLAALKLDRKPAGTMAHSLVMALGAIEGTESQAFQAFHRYFPGAPLLIDTYDTIAAAEMLSKQLQAGEIQLSGVRLDSGDLVDLSKKVRSLLPGVPIFASGDLDEYRIAELKAQGACIEGYGLGTQLVTGSPVNGVYKLVEIDGIPVMKEATGKMTYPGRKQIFRGENGDRLGLITEAANGEIPLLQLVLKQGERVNEPETIAEIRDRATVNVARLPKAVRCLENPVSIPVELSQALSELTDRTRSRHA
>NZ_AP018203.1|WP_017286661.1|2091057_2092053_-|hypothetical-protein
MNDPIAPIVNQFDQDPSAIRIQKLLVYVCRNHWESEMSLFDASQWRSLIEEVRIAYPTLDQLRSRLTHQIGTLNKSKEYAAIGQIILSVLEGLYAEGAVTMVSASRRSTKLEQDINIHRIKKLLIYTCKKYWEANSYIIEQTALPDLIDTLIKQYPTTAELRSGLNKMVKTLNKSVEYALIAEIIIREVEPLYGNDQPADNLALCDPIDLFDVRCAILKSVNPLQTKVLLFSSVYYLFEFCEQDWSNLKLYSLDGLLRTVVIQSATIEELQQLLNSKASQLRDPDTYLEIVPVLIRSLKKDYNDLRQKLQQVSSVSSLADTTIARSTRAFS
>NZ_AP018203.1|WP_017286662.1|2092501_2092822_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MATYTVEISHQGQIYTIEVPDDRTILSVANDDKGLNLPVSCTAGVCTTCAALITEGTVDQTDGMGVSPDLQAQGYALLCVSYPRSNIKLETEKEETVYKKQFGQQG
>NZ_AP018203.1|WP_017286664.1|2092975_2094055_+|DUF3326-domain-containing-protein
MNKPSFTVGLIVPTGIGAAIGGYAGDAMPVARAISEVADCLITHPNVLNGAQLYWNLPNALYVEGYGLDQFAAGHWGLLPTTSNRIGLILDQAIEPDLKLRHLQVADAARATLGLNILDYVVTDQPLNVELRTAKSGATWGTIEHPDSLLRAAEKLIQAGADAIAVVARFPDDTGSEALQNYRHGQGVDPLSGAEAVISHLIVRTFHVPCAHAPALSALPLDPDLSPRSAAEELGHTFLPCVLVGLSRAPRFTEFPKAHAIWADQMNALVIPASACGGSAILHLSQTRTRIIAVQENQTKLNVSAEALGIRATIVKSYLEAIGILICDRAGINPTALSPEIAALKRFDQSIRGSQLTGI
>NZ_AP018203.1|WP_017286665.1|2094121_2094706_+|CPBP-family-intramembrane-metalloprotease
MAQQIPDTPEMQPLTRTQVLIAMGVTAVVLLVVSKIWLHFSQLSMLPVRFSVQALLEGLALGVGISIASAIVYRIWGEYRRSADQYLTMVIKPLLVPDLLWLGLLPGLSEELLFRGVMLPEFGLDELGVLLSSLCFGVLHMSNLKQWSYVVWASLVGIALGLSAVWTGNLLVPIVAHILTNLVSGATWKLSNRD
>NZ_AP018203.1|WP_017286666.1|2095268_2096258_+|sigma-70-family-RNA-polymerase-sigma-factor
MATKLPTDSFPVDSVVTEGDIDLSELESLENEDLSPEALAKSLRGKTSEYLGLSDDSVGMFLREMARYPLLTQAQEIELAREISKGGVIGERAKRKLVRANLRLVVSIAKKYLNRGVPFLDLIQEGAMGLMRAAEKFDYERGYKFSTYAYWWIRQGITRAIASQSRTVRLPVHMVEKLNQVRKVRQMLSQELGRKPTKQELAGALDMEEDKLEQVLDVSQRTLSLHAWVGRDEDTELMQLIEDADNVAPNDNLDHKLLVDRLNSVLDHLSDREREIIKLRFGLTDGQHYTLSEIGQIYDLSRERVRQIQAKAMRKLRHPRRQALLKDWM
>NZ_AP018203.1|WP_026148451.1|2096453_2096864_+|response-regulator-transcription-factor
MLSSECKVLRVLIVDDHELTRFSLKLAMQRQAGIELVGLASNGREAVEMADRHCPDVIVLDLQMPIMDGLSASTQIKSVHPQIKILAYSSLEDPQTEVMLQTAKVDAFCNKETAVQDLIAIVNQLGQEAEHKKSHS
>NZ_AP018203.1|WP_017286668.1|2096965_2097388_-|hypothetical-protein
MQASLRWSIFPTAIMAVFAMSNLAASQQVVSISSNTSPITLNGISGGDKKDSSCAGFIGDRPNHTVQVTADRNLKFTLQGSGEPTLLIIGTQGQNFCVQADRLSNGKVEIPGRWTKDNYSVFVGDRGRARNPYTLSISPQ
>NZ_AP018203.1|WP_017286669.1|2097558_2098119_-|DUF2808-domain-containing-protein
MKSQFAAIVFSLLSLTLPAQAVQVRGTTYFVSPPRLVGASTTQNHVYAWSATYYFTLEIPDNSGEPLQRVTIAQDDGVDRVRFNLKETEAFDGDRRSRTKLGLGEVTLDEKTKAVTVNFNPPIPAGKRVTIALAPERNPAYGGVYLFGVTAFPTGDPAYGQFLGFGRISIYDNRFDSFFFRPRFRH
>NZ_AP018203.1|WP_017286670.1|2098615_2099086_+|DUF4149-domain-containing-protein
MTVASKVSSNFVNWRKILILTLAFWISSSVLLDLVVLPSLFAAGMMSQPDFATAGYGIFWIFNRLELLCAASVLTSVLVQQQSEKTLTSIVLAGVLFAIAITCTYLLSPQMSALGLNLNLFAPAQVPTGMDQLHIGYWMLESCKLLAGGWLLKREF
>NZ_AP018203.1|WP_017286671.1|2099196_2099487_-|TMEM165/GDT1-family-protein
MDWQLMGISFVTVFLAELGDKSQLAAIALSSNSNNSPKAIFLGTVAALVLASFIGVILGEGTAQLLPTKWTKIIAAIGFLILAVRLLWFSNCEEEA

Crispr_ID: NZ_AP018203_6

• CRISPR_ID: NZ_AP018203_6
• CRISPR_location: 2607420-2607493
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_6

Consensus_repeat	Method
TCAACAGGTTTCGGTTCCTCAAC	CRISPRCasFinder

spacers of NZ_AP018203_6

>6.1|2607443|28|NZ_AP018203|CRISPRCasFinder
TGGCGTTTCTTTCACTTCTGGAGCAGTC

CRISPR arrays and Neighbor proteins around NZ_AP018203_6

CRISPR arrays

The CRISPR arrays of NZ_AP018203_6

>merge|NZ_AP018203|6|2607420-2607493|CRISPRCasFinder
TCAACAGGTTTCGGTTCCTCAACTGGCGTTTCTTTCACTTCTGGAGCAGTCTCAACGGGTTTCGGTTCCTCAAC

>NZ_AP018203|6|6|2607420-2607493|CRISPRCasFinder
TCAACAGGTTTCGGTTCCTCAAC	TGGCGTTTCTTTCACTTCTGGAGCAGTC
TCAACGGGTTTCGGTTCCTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017287234.1|2619135_2619978_-|hypothetical-protein	unknown	unknown	gnl|CDD|227078
NZ_AP018203.1|WP_017287225.1|2605546_2607016_-|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|215497
NZ_AP018203.1|WP_017287219.1|2599470_2601033_-|site-2-protease-family-protein	unknown	unknown	gnl|CDD|100081
NZ_AP018203.1|WP_017287232.1|2617383_2617839_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287216.1|2596139_2597780_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|381113
NZ_AP018203.1|WP_017287228.1|2611696_2612707_+|phosphoribulokinase	unknown	unknown	gnl|CDD|180975
NZ_AP018203.1|WP_026148517.1|2609971_2611213_-|ferredoxin--NADP(+)-reductase	unknown	unknown	gnl|CDD|99804
NZ_AP018203.1|WP_017287223.1|2603498_2604575_+|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl|CDD|224014
NZ_AP018203.1|WP_017287233.1|2617874_2619128_-|O-antigen-ligase-family-protein	unknown	unknown	gnl|CDD|225844
NZ_AP018203.1|WP_017287217.1|2597899_2598679_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287221.1|2602361_2603084_+|sugar-transferase	unknown	unknown	gnl|CDD|376775
NZ_AP018203.1|WP_017287230.1|2613093_2613831_+|hypothetical-protein	unknown	unknown	gnl|CDD|237864
NZ_AP018203.1|WP_017287220.1|2601122_2602262_+|glycosyltransferase	unknown	unknown	gnl|CDD|340833
NZ_AP018203.1|WP_017287224.1|2604591_2605542_+|GDP-L-fucose-synthase	unknown	unknown	gnl|CDD|187550
NZ_AP018203.1|WP_017287231.1|2613949_2617066_+|valine--tRNA-ligase	unknown	unknown	gnl|CDD|235582
NZ_AP018203.1|WP_017287237.1|2623214_2624621_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287218.1|2598735_2599449_-|hypothetical-protein	unknown	unknown	gnl|CDD|350277
NZ_AP018203.1|WP_017287236.1|2621416_2623060_-|iron-uptake-porin	unknown	unknown	gnl|CDD|335962
NZ_AP018203.1|WP_017287215.1|2595698_2596136_-|anti-sigma-regulatory-factor	unknown	unknown	gnl|CDD|225083
NZ_AP018203.1|WP_017287235.1|2620059_2621082_+|NAD(P)-binding-protein	unknown	unknown	gnl|CDD|225915

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017287234.1|2619135_2619978_-|hypothetical-protein	gnl|CDD|227078	COG4735, COG4735, Uncharacterized protein conserved in bacteria [Function unknown].	9.93934e-64
NZ_AP018203.1|WP_017287225.1|2605546_2607016_-|redoxin-domain-containing-protein	gnl|CDD|215497	PLN02919, PLN02919, haloacid dehalogenase-like hydrolase family protein.	2.1881e-140
NZ_AP018203.1|WP_017287219.1|2599470_2601033_-|site-2-protease-family-protein	gnl|CDD|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	4.57186e-49
NZ_AP018203.1|WP_017287216.1|2596139_2597780_-|SpoIIE-family-protein-phosphatase	gnl|CDD|381113	cd17569, REC_HupR-like, phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains. This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.1107e-53
NZ_AP018203.1|WP_017287228.1|2611696_2612707_+|phosphoribulokinase	gnl|CDD|180975	PRK07429, PRK07429, phosphoribulokinase; Provisional.	0
NZ_AP018203.1|WP_026148517.1|2609971_2611213_-|ferredoxin--NADP(+)-reductase	gnl|CDD|99804	cd06208, CYPOR_like_FNR, These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins, such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap between the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2, which then transfers two electrons and a proton to NADP+ to form NADPH. CYPOR serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases, sulfite reducatase, and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via FAD and FMN. CYPOR has a C-terminal FNR-like FAD and NAD binding module, an FMN-binding domain, and an additional connecting domain (inserted within the FAD binding region) that orients the FNR and FMN -binding domains. The C-terminal domain contains most of the NADP(H) binding residues, and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule, which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	1.28212e-153
NZ_AP018203.1|WP_017287223.1|2603498_2604575_+|GDP-mannose-4,6-dehydratase	gnl|CDD|224014	COG1089, Gmd, GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane].	0
NZ_AP018203.1|WP_017287233.1|2617874_2619128_-|O-antigen-ligase-family-protein	gnl|CDD|225844	COG3307, RfaL, Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane].	3.82199e-10
NZ_AP018203.1|WP_017287221.1|2602361_2603084_+|sugar-transferase	gnl|CDD|376775	pfam02397, Bac_transf, Bacterial sugar transferase. This Pfam family represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways.	3.69313e-91
NZ_AP018203.1|WP_017287230.1|2613093_2613831_+|hypothetical-protein	gnl|CDD|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	0.00623184
NZ_AP018203.1|WP_017287220.1|2601122_2602262_+|glycosyltransferase	gnl|CDD|340833	cd03804, GT4_WbaZ-like, mannosyltransferase WbaZ and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.	1.15117e-173
NZ_AP018203.1|WP_017287224.1|2604591_2605542_+|GDP-L-fucose-synthase	gnl|CDD|187550	cd05239, GDP_FS_SDR_e, GDP-fucose synthetase, extended (e) SDRs. GDP-fucose synthetase (aka 3, 5-epimerase-4-reductase) acts in the NADP-dependent synthesis of GDP-fucose from GDP-mannose. Two activities have been proposed for the same active site: epimerization and reduction. Proteins in this subgroup are extended SDRs, which have a characteristic active site tetrad and an NADP-binding motif, [AT]GXXGXXG, that is a close match to the archetypical form. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.02616e-157
NZ_AP018203.1|WP_017287231.1|2613949_2617066_+|valine--tRNA-ligase	gnl|CDD|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_AP018203.1|WP_017287218.1|2598735_2599449_-|hypothetical-protein	gnl|CDD|350277	cd18710, PIN_VapC-like, uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Matelska et al. recently classified PIN-like domains into distinct groups; this subgroup includes some sequences belonging to one of these, PIN_4-2.	6.9646e-37
NZ_AP018203.1|WP_017287236.1|2621416_2623060_-|iron-uptake-porin	gnl|CDD|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	3.28849e-41
NZ_AP018203.1|WP_017287215.1|2595698_2596136_-|anti-sigma-regulatory-factor	gnl|CDD|225083	COG2172, RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms].	1.99027e-28
NZ_AP018203.1|WP_017287235.1|2620059_2621082_+|NAD(P)-binding-protein	gnl|CDD|225915	COG3380, COG3380, Predicted NAD/FAD-dependent oxidoreductase [General function prediction only].	7.0368e-91

Protein sequences

>NZ_AP018203.1|WP_017287225.1|2605546_2607016_-|redoxin-domain-containing-protein
MVRAPEFPKNLTWLNVQRPLSLKEFRGRILLLDFWTYGCINCIHSLPDLKYLEDKYHDLLTILSIHSAKFENESSIKNIRQAILRYEITHPVLVDRDFQVWESYAVRAYPTFVLIDANGRIVRTIAGEGRRELLDQLIGELVNGIEPKDIQFELEEMPILPLAFPGKVLASDRLFIADSGHHRIVVTTFEGEVLDIIGTGFSGLKDGSFDEAQFSNPQGMTIHQNILYVADTGNHAIRCIDLEKRIVSTIAGTGNQSKTIYPHGGKALEVDLNSPWDLVWNGDRLFIAMAGAHQIWEMQDDVIQTFAGTGAEASFDGAIQEAAFAQPSGITTNGKELWIADSETSSIRSIDLETSQVKTVCGGGDLYNFGDVDSIGEKARLQHCLDVEFAAELWIADTYNHKIKRINSDGFCQTVFTESFSEPSGISATATHLFIADTNHHAIRKIDLKTLEISSIDFPSLCAPTVCFPHYISALKKGDSKERPHEQGE
>NZ_AP018203.1|WP_017287224.1|2604591_2605542_+|GDP-L-fucose-synthase
MTSTTFDLHNKRILVTGGAGFLGRQVVRQLCESGADPQKITVPRSHDLDLRKMENCQRAVDQQDVVVHLAAHVGGIGLNREKPAELFYDNLMMGTQLIHAAYEAGVQKFVCAGTICAYPKFTPVPFKEDDIWNGYPEETNAPYGVAKKALLVQLQSYRQQYGFDGIYLLPVNLYGPEDNFDPSSSHVIPALIRKVYEAQQAGAATLPVWGDGSPTREFLYVDDAARGITTALQHYSECEPVNLGTGYEISIRDLITLLCDLMEFKGEIVWETDKPNGQPRRCLDTQRAKEKFGFSAQVSFEEGLKKTIDWYRQNPQ
>NZ_AP018203.1|WP_017287223.1|2603498_2604575_+|GDP-mannose-4,6-dehydratase
MTQRKRALVTGITGQDGSYLSELLLEQGYEVHGIIRRTSTFNTDRIDHIYEDPHVEGARLFLHYGDLTDGTTFRRILEEVKPSEVYNLGAQSHVRVSFDAPEYTADAVGMGALRILEAVRDYQQRIGEQVRYYQAGSSEMYGKVQQVPQTEETPFYPRSPYACAKVFAHWQTVNYRESYDMFACNGILFNHESPRRGETFVTRKITRAVAQIVAGRQKKLFMGNLDAKRDWGYAKDYVRAMWLMLQQEQPDDYVVATGETHSVHEFLDIAFGRVNLDWKDYVEFDERYLRPAEVDLLIGDPAKAKKQLGWEPSVTFEELVHLMVDADLQALGISTPGNGHAKVADYATVRQNLAGVSF
>NZ_AP018203.1|WP_017287221.1|2602361_2603084_+|sugar-transferase
MTADSQFVPGKRIRSIFKRGKPIGKPSIFNTRNALETDFAKRLFDIVFSLSVLILFSPVYFILALLIALSSSGPIFYVQERVGKDFKRFGCIKFRTMVRNADEVLMDLISTSPQMREEFETTFKLKSDPRITWIGKFLRITSLDEFPQFWNVLVGDMSVVGPRPLVVEELPKYGAHIDKVLTIRPGITGLWQVSGRNDIPYPQRVRIDVYYASCHNFLLDLWIIVKTIGVVVFPKNNGAY
>NZ_AP018203.1|WP_017287220.1|2601122_2602262_+|glycosyltransferase
MNLKYALVHEWLTPKATGGSELVVQEILKHIDADLYALIDFESVNPNSYLYRRKIGTTFLQHFPFAKNGVQKYLPFLPIAIEQLDLHEYDVILSSYHAVAKGVITSPHQLHICYCHAPMRYVWDMTFEYLRNSRVGHGIAGIFTRYLLHQLRQWDVISSNRVDYFIANSHHTARRIWRCYRRSAEVIYPPVEVDRFSYEPQKQDYYLTVSRLVGYKKIPLIVQAFNQLDLPLVVIGSGAELSTIQKIAKPNIKILGWQPDDVVEQYMKQAKAFVYAAYEDFGIAPVEAQACGTPVIAYGAGGTAETVRDLREYQSQGTGILFPNQTEAAIVEAVQAFEQHQAIFQPEASRSFAMNFHPDIFKQRYLDFIDRAYREFQSR
>NZ_AP018203.1|WP_017287219.1|2599470_2601033_-|site-2-protease-family-protein
MGLANENSLGYEKSYIVDLVVFHAIVRSSLGVEMITALAVLVALGILAVGFNRARPYGKLGILAWFQSVVLMSPWIIFFGLFSAGIYLNLAGMLLLFVISTGIYIWIGRKLRAEGQEFLAQRAAAKVAIESAFPKSDDATEAPVMIPPESLSIPNEDLQAIKSIFGIDTYFLTETISYQDGAIFKGNLRGDPDSTHAKLTENLKAQVGDRYRLFLIENQEEKPVVVVLPSKNDPKPLTLTQTLLSIVLFLATIAASLETGGILLGFDFYGSPERYAEVLPFSIGILAVLLAHEFGHWIVAKRYQIKLNLPFFIPTWQIGSFGAITKFASLLPNRSTLFDISVAGPLAGGAVAFGMLIAGLLMSHEGSGFKVPTQFFEGSILVGTLARVIMGAEIQRSIVEVSPLVVLGWIGLVVTAINVMPAGQLDGGRIVQAIYGRKIAARATVATIIILGLASFVNPLALYWAIVIVVLQRTPERPSLNELTEPDDARAGIALVVLFLMLMILLPLTPSLAGRLGIGG
>NZ_AP018203.1|WP_017287218.1|2598735_2599449_-|hypothetical-protein
MLDAPEIFLLIDLNTLFACKPYEWLEFSPMGRCFVPEAVHQELEAWAGHRSDTAESKIAREYCRLMLEGDWYLARSPIPADTQRPFTRRARLAIDVRNSAESLAQSSPRQLVVVVSNDRALLQQLHALRLDNLTGVPVSTFLTWSRTKRQPPVVIQHVRSMQSHSLQLLSAGNHRHLRPFLTSNYPKFSSQPVYHSTWRDRVLPLLPLILILSGLTLGWCFAQPFIQQLPSTSEQNQ
>NZ_AP018203.1|WP_017287217.1|2597899_2598679_-|hypothetical-protein
MRSPVQIISAIVLMSALSLGSGIPLLQASAAPIRHPTVLLTTAYPKTLSWRVRKDLARRVGIPTTELRVMQAERKTWGDGCLELPKTDEFCTQQLIEGWKVVVAHQNQTWVYHTDLQGRLLRLAESQPSELLPKNVVFRSRMSGGFAGQTYDTILLSDGTMQQAIDMGGDPRRTQSASSSASLRAWKITPQKVEEFRELLKREQFQNFNRKTYSPPQGAADFFIVTLASPVGTVQYADIEQENLPRSLQTIIQAWNALK
>NZ_AP018203.1|WP_017287216.1|2596139_2597780_-|SpoIIE-family-protein-phosphatase
MRREKLKLLIVDDEPDNLDLLYRTFRRDFDVIRAESAIEALKVLDEQGEVAIIISDQRMPEMLGTEFLSRTVDRFPDTIRIVLTGYTDVEDLVDAINSGKVFKYITKPWKSQQLQVVVEQAAETYQVLKQRTADLRRALRRESSLNAITTAIRESLDYQNMLHTIVETIGLTFEASCCMLHPVEGERLKSNSAMYCAVNVPFKSCEDDRTSDLVQIVLHDSTARMKSQNPPHFVLPLRYQKDLLAILSLHRESDQPFWSTEDLELIEVVTEQAALAISQARLYRRTQEQAEQIRAELEVARQIQTNLLRQTLPRLDNLKVQACCHPAREVGGDFFEVYQHPQGDLWLAVGDVSGKGVPAALFMASAISVLRRELSQEVSPEPDEVMRNLNSILSQDLMGTNCFITMVLARYTRSSGQLVYANAGHIYPLVWSKHTIAQAIEPTYLKVRGIPLGILPKWNAIAGKRLLQDGEILLLTSDGITEATVRPEGEVNLASDPARAMLRQTGLWKLLQQAGESLDLKQLLAQIQAHNAIQEDDQTILSLEVL
>NZ_AP018203.1|WP_017287215.1|2595698_2596136_-|anti-sigma-regulatory-factor
MKTELHVPSDLRFLTVVESWLLESLKIEIGDQIDWTRQSSRLRLALVEAYSNVVRHAHRNQPDLPVVVRLELRDRDLAIEIWDHGQGFDISSYLAPSPEMMQEHGYGWLILNRLMDRVEYQLQVNGRNCLKLQANLLEMSAQSSR
>NZ_AP018203.1|WP_026148517.1|2609971_2611213_-|ferredoxin--NADP(+)-reductase
MYYSSASGAANTQSGNRVFRYEVIGLGQSDADGSSGSTVRKSGSTFFNVPYSRMNSFMQRISRMGGTIVSIQPLDANGSGTGNVTVEQKAPAIAQENASASSSTGSKPMTQAKAKKHADVPVNIYKPNSPFIGKCISNDELVGEGGIGTVRHIKFDISAGDLTYVEGQSIGIIPPGLDKNGKPEKLRLYSIASTRHGDDVDDKTVSLCVRQLEYKHPETGETVYGVCSTYLCNLEPGADVKITGPTGKEMLLPEETDTNVIMMATGTGIAPMRAYLWRQFKDNERAANPNYQFNGFSWLIFGIPTSANILYKGELEEMAQKYPNNFRLTTAISREQQNKDGGRMYIQDRVAENAAELYKLMKDEKTHTYICGLKGMEDGIDAALGAEAAKEGVEWKEFRSAMKKAGRWHVETY
>NZ_AP018203.1|WP_017287228.1|2611696_2612707_+|phosphoribulokinase
MTSKPDRVVLIGVAGDSGCGKSTFLRRITDLFGEDFVTVICLDDYHSLDRKQRKETGITALNPKANNFDLMAEQIKALKSGETIDKPIYNHETGEIDPPEKIEPNHIVVIEGLHPLYDKRVRDLIDFSVYLDISDEVKIAWKIQRDMAERGHSYEDVLAQINSRKPDFDAYIDPQKEFADVVIQVLPTQLIKEDKERKVLRVQMIQRDGIEGYDPVYLFDEGSTIDWTPCGRKLTCSYPGIRMHYGPDVYYKHGVSVLEVDGQFDKLEEVIYIEQHLSKTSAKYNGEVTELLLQHREYPGSNNGTGLFQVLTGLKMRATYERLTNQAGATKVPANV
>NZ_AP018203.1|WP_017287230.1|2613093_2613831_+|hypothetical-protein
MATSRRTQTSTRRTSNRRTAAKVTETPESSAPAPAETPEATSESPSPDVGESLEVNEPPIVSEQPEVSEPTDPISETALDSDFQEASTESTPKESIPEEPPMSNADVIEATATPAEGNGSAIEIRSDVPSLSIWNRPVMPSDIEIVGTITSSGERPIEASHLAVFGTILNGRPILASNLKVAEMLPGNRPIFYSDFHSVSALTLAGDRPVMASASGLMHAEKLPGDRPIFTNDVDDPSTLMGFID
>NZ_AP018203.1|WP_017287231.1|2613949_2617066_+|valine--tRNA-ligase
MIASLPTQYNASTTEAKWQKFWEENQVFKADPSQPGEPYCVVIPPPNVTGSLHMGHAFESSLIDVLIRYQRMLGKNTLWLPGTDHASIAVQTILERQLKEEGKTRNDLGREQFLERAWKWKAESGGTIVNQLRRLGVSVDWSRERFTMDEGLSAAVLDAFVKLHDEGLIYRGNYLVNWCPSSQSAVSDLEVENKEVDGNLWYFKYPIVDGDGFLVVATTRPETMLGDTAVAVNPNDDRYKHLIGKTLILPLVYREIPIIGDDHVDPSFGTGCVKVTPAHDPNDFEMGQRHKLPSINVMNKDGTMNENAGEFQGQDRFVARKNVVKRLEEEGCLEKIEPYKHTVPYSDRGKVPVEPLLSTQWFVKIEPLASRALSFLDDQTSPKFVPDRWTKVYRDWLVSLKDWCISRQLWWGHQIPAWYAVSETNGEITDYTPFIVARSQAEAQQKAIEQFGESVQIEQDPDVLDTWFSSGLWPFSTLGWSDTDAEDYKRYYPTATLVTGFDIIFFWVARMTMMAGHFTGQMPFKDVYIHGLVRDENNKKMSKSANNGIDPLILIDKYGTDALRYTLIREVTGAGQDIRIAYDRKTDESETVEASRNFTNKLWNASRFVMLNLDGKTPAQLGAPDQLELSDRWILSRFHQVAQDVRTSLDRYGFGEAAKSLYEFIWGDFCDQYIELVKSRLQGEPTTSRLAAQQTLAYVLEGTLKLLHPFMPHITEEIWHTLTQAPDTESLALQPYPNPDVSAIDANLERQFDLIINSIRTIRNLRAGAEIKPGARITVAMQTEDPQEKQTLIAGQSYIKDLARVETLSITSTADQPARTVSAPKASAIADDAPVLVMALDIVGSFIAKNQNVLLSLLLIGSIIFAIKIAATVTSGIHEIPLLAPFLEVVGIIYTIWFTKARLWNKDDRQVFFKQVQTFTREVIGEPAPIVAVAPAEEPQISEAADNVETDDVQTIVGVTGTVKISIPLAGLVDFEAMKAKIERDLKKVDAEIQSLRGRLSNPKFVDKAPPEVVQSNRDALAEAEKQAEILKSKLDRL
>NZ_AP018203.1|WP_017287232.1|2617383_2617839_+|hypothetical-protein
MLHLAQVQKKGYLGKAGLRLLAAQKSEHVWTRLPEEETVLSAEANTYADGLLVLVEISSSNQILDIREAKDWVLELVQRYLTYGITPAFLQQETERAEQWRQSLTLESQELARRAIELEARREQIQELEEELKNEKKQLEMLMSQVRAQQE
>NZ_AP018203.1|WP_017287233.1|2617874_2619128_-|O-antigen-ligase-family-protein
MKALQPHPDPNFQRHWNVVQIGLFLLPFSAFLGGTSILMVAIAIWVRKFSSLSREPVNRGFAILGLVMIAAAWFADDRANAFLGLFNFLPFFFTFAALADLIRSPKQLTQIAWIWVITSIPVTVIGILQLLNFGGMPSLLWGLISWKVFAGGNPVGRMASVFEYATILANYYAIVFILSLGLWLQERRKLLIGIVLLNAIGLILTNSRNVWAIAVLACLAFALYQGWKTIVAAVGAITGIILGAAFAPDSIALPLRKIVPRFFWARLNDQMYSDRPVNQLRSTQWKFAWNMTEQRPLTGWGLRSFARLYTEQMQLWIGHPHNLFLMLSSESGLPAAVMLYGLVGWIMAQGIWIWKALSPTNRPIYFTFWIAFLACTLFSFLDIALFDARINLMGWVLLAAIWKMEESGEWGVRLRGS
>NZ_AP018203.1|WP_017287234.1|2619135_2619978_-|hypothetical-protein
MDEFRAALELATDDELRELTEILFRPKFNPLDYVNAPDPIDLQSLCREDWLDAIDDRFRFLAADGITVLRRKTGQVSYRQVLIQVCRYLKLPYSASMSTTDLEAEVFLSLLNRAWKQLPASEQTALTNRIQNTLSKTDFVADLPLSLQKNPMSLVVKGGSALAVNTVLQPLLLQHIARQFALHFARYQVAQQAITQGGIAAATQIQTQVSMQLARRGMTMASARYTASRAAFAFVGSALWAWFLADLGWRAIATNYGRVIPTIFALAQIRLTRSECFEPI
>NZ_AP018203.1|WP_017287235.1|2620059_2621082_+|NAD(P)-binding-protein
MLDSQFEIAIVGAGMSGLTCAQMLHQAGYKVVVLDKSRGLGGRMATRRLHGTHADHGVCYLKPKSDEFQNLLDQLVDRQVSRVWTDRIHEWVDGQIRAPESQAACYVSPTGISAIAKFLSAGLTLKLNHRVTEIKPGWQLHCESGETISAQVVVIAIPAPQAAQLYEWDKLNQVEYSPCISAIAVYPAERQSEVEQLPWKALICADSELGWIGLDSTKQIHPVQPAVVVQSNAAFATRYLEDLDLQKVGERLLERASEVGLPWLTSPEVLQVHRWRYAFPIQPLPESFLVADTEQPLMFTGDWCGGNRVENAFQAGMATARELNRRLENRSLGERFWWQI
>NZ_AP018203.1|WP_017287236.1|2621416_2623060_-|iron-uptake-porin
MTKSLFVHSLVVAASLGIATSATAAEVAELTAQEPFNQVTSVSQLSDVRPTDWAFQALQSLVERYGCIAGYPDRTYRGNRALTRYEFAAGLNACLDRVNELIAAATADLVKKEDLATLQKLQEEFAAELATLRGRVDSLEARTSTLEKQQFSTTTKLNAEVVLGITGVAAGRDFIRREFDPVTGTSNEVVDRVSRNTIVGNRVRLNFDTSFTGRDILRTRLQAANLSALPAGINGNTLTNEGALRFAGGENNELGVDALNYTFPLGEKTTVVIEANAGAIDDFTDTLNPYLDGDGGSGALSHFGTRNSIYYLGNGAAGTGVGVRHKFSDALELSLGYLAGEPSSPAPGNGLFNGSYGALAQLTFRPSERLGIGLTYIHAYNVDFSGNGAVGSTRANFRSLAENGFLADEVPTSANAYGISASFQITPQVVFNGSVGYTNAQSLQPGNRGDLDIWNWSAGLAFPDFLKKGSLAGIIVGMEPRVSSSSGTFGQAIGRDRNTSLHIEGFYQYQLTDNIAITPGIIWLTAPNHDNRNDDIVIGTIRTTFTF
>NZ_AP018203.1|WP_017287237.1|2623214_2624621_-|hypothetical-protein
MKKIGAVPWKSVGSFLAIASAAGCVVTSIWLSTEFIMDPKSVAWMNRYLPDDAQIPISAWDDPKSLKEVQADLRKAGLYAGEVVRVETVKQGKPKQIDILMPVFRPQADQDDRLVELRAYRLVKNSTARKPEALQFVNQIEVREMREDFVTEPLVRARAMNPSSDRELPFTNVQRLEDRAPQNGIWLNVNGKLQQGDSSIAYGQVIYYNPITTAMSAMLSWTSPDGELPTWQAVPKGRPAEFVVNQTVGLEPDFQVYQLRSVKRKNIPFQLQPISLSQPAIANGAFTDALFLARSGLWSNASEYLKSVKRRVGSAWTPAAQAQMDLIDRHAKITKTQADQPWANVSQQILANLLDGRWDRAAQVMEKSSIDHPEVLDVLKYDPGRVQKRINAALQFNPSRSEVQMWGALRMATQQGKPNAIAWLKNQPLDSSARRAQTLKMINQLDAMTFGNLMPADEPAKTSQNKKI

Crispr_ID: NZ_AP018203_7

• CRISPR_ID: NZ_AP018203_7
• CRISPR_location: 3114099-3114198
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_7

Consensus_repeat	Method
CTTCTGGTTCACCGACGACAATCGGTTC	CRISPRCasFinder

spacers of NZ_AP018203_7

>7.1|3114127|44|NZ_AP018203|CRISPRCasFinder
ACCGACGACAATCGGTTCACTTACAACGATTGGCTCACCAACTA

CRISPR arrays and Neighbor proteins around NZ_AP018203_7

CRISPR arrays

The CRISPR arrays of NZ_AP018203_7

>merge|NZ_AP018203|7|3114099-3114198|CRISPRCasFinder
CTTCTGGTTCGCTAACCGCTTCTGGTTCACCGACGACAATCGGTTCACTTACAACGATTGGCTCACCAACTACTTCTGGTTCACCGACGACAATCGGTTC

>NZ_AP018203|7|7|3114099-3114198|CRISPRCasFinder
CTTCTGGTTCGCTAACCGCTTCTGGTTC	ACCGACGACAATCGGTTCACTTACAACGATTGGCTCACCAACTA
CTTCTGGTTCACCGACGACAATCGGTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017287754.1|3117252_3117957_-|thiol:disulfide-oxidoreductase	unknown	unknown	gnl|CDD|172475
NZ_AP018203.1|WP_017287757.1|3120308_3122174_+|asparagine-synthase	unknown	unknown	gnl|CDD|238364
NZ_AP018203.1|WP_017287758.1|3122173_3122947_+|hypothetical-protein	unknown	unknown	gnl|CDD|188054
NZ_AP018203.1|WP_017287744.1|3106640_3107063_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287761.1|3124337_3125459_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|100107
NZ_AP018203.1|WP_017287746.1|3108121_3109204_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287741.1|3104722_3105160_-|hypothetical-protein	unknown	unknown	gnl|CDD|380410
NZ_AP018203.1|WP_036045731.1|3116425_3117091_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224059
NZ_AP018203.1|WP_017287745.1|3107059_3107953_+|hypothetical-protein	unknown	unknown	gnl|CDD|275319
NZ_AP018203.1|WP_017287751.1|3114859_3115777_+|hypothetical-protein	unknown	unknown	gnl|CDD|277324
NZ_AP018203.1|WP_017287747.1|3109575_3111264_+|serine-protease	unknown	unknown	gnl|CDD|274350
NZ_AP018203.1|WP_017287742.1|3105386_3106232_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287755.1|3118278_3119919_+|lasso-peptide-biosynthesis-B2-protein	unknown	unknown	gnl|CDD|379721
NZ_AP018203.1|WP_017287739.1|3102493_3103756_+|HD-domain-containing-protein	unknown	unknown	gnl|CDD|224004
NZ_AP018203.1|WP_017287760.1|3123459_3124341_+|hypothetical-protein	unknown	unknown	gnl|CDD|238899
NZ_AP018203.1|WP_017287740.1|3104008_3104656_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_AP018203.1|WP_017287738.1|3101230_3102469_+|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|177681
NZ_AP018203.1|WP_017287756.1|3119987_3120305_+|PqqD-family-protein	unknown	unknown	gnl|CDD|377508
NZ_AP018203.1|WP_017287743.1|3106228_3106624_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287752.1|3115773_3116412_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017287754.1|3117252_3117957_-|thiol:disulfide-oxidoreductase	gnl|CDD|172475	PRK13972, PRK13972, GSH-dependent disulfide bond oxidoreductase; Provisional.	6.2465e-94
NZ_AP018203.1|WP_017287758.1|3122173_3122947_+|hypothetical-protein	gnl|CDD|188054	TIGR00477, Tellurite_methyltransferase, tellurite resistance protein TehB. Part of a tellurite-reducing operon tehA and tehB [Cellular processes, Toxin production and resistance].	0.000149622
NZ_AP018203.1|WP_017287761.1|3124337_3125459_+|methyltransferase-domain-containing-protein	gnl|CDD|100107	cd02440, AdoMet_MTases, S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).	8.65699e-12
NZ_AP018203.1|WP_017287741.1|3104722_3105160_-|hypothetical-protein	gnl|CDD|380410	cd07007, cupin_CapF-like_C, Staphylococcus aureus CapF and related proteins, C-terminal cupin domain. This family contains cupin domains of proteins homologous to Staphylococcus aureus CapF (also known as WbjC in Pseudomonas aeruginosa and FnlB in Escherichia coli). CapF is a bifunctional metalloenzyme produced by certain pathogenic bacteria and is essential in the biosynthetic path of capsular polysaccharide (CP), a mucous layer on the surface of bacterium that facilitates immune evasion and infection. Thus, CapF is an antibacterial/therapeutic target. In S. aureus, enzymes CapE, CapF and CapG catalyze the sequential transformation of UDP-D-GlcNAc in the CP precursor UDP-L-FucNAc via the intermediate compound UDP-N-acetyl-L-talosamine (UDP-L-TalNAc). CapF consists of two domains; the C-terminal cupin domain catalyzes the epimerization of the compound produced by the upstream enzyme CapE, and the N-terminal short-chain dehydrogenase/reductase (SDR) domain catalyzes the reduction of the compound afforded by the cupin domain, requiring one equivalent of NADPH. The cupin domain is crucial for catalyzing the first chemical reaction, and also important for the stability of the enzyme. Similarly, in P. aeruginosa, WbjC, WbjB and WbjD enzymes synthesize UDP-N-acetyl-L-fucosamine, a precursor of the lipopolysacharide component L-fucosamine. The cupin domains contain a conserved "jelly roll-like" beta-barrel fold.	4.94492e-06
NZ_AP018203.1|WP_036045731.1|3116425_3117091_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.17794e-116
NZ_AP018203.1|WP_017287745.1|3107059_3107953_+|hypothetical-protein	gnl|CDD|275319	TIGR04526, predic_Ig_block, putative immunoglobulin-blocking virulence protein. Members of this family are putative virulence proteins of Mycoplasma and Ureaplasma species. Members share a region of sequence similarity (see TIGR04524) with protein M, a Mycoplasma genitalium protein that binds a conserved light chain region of IgG and blocks its protective function of antigen-specific binding. The seed alignment for this model includes an N-terminal signal-anchor domain and a proline-rich linker domain, and a C-terminal extension, in addition to the protein M-like domain recognized by TIGR04524. [Cellular processes, Pathogenesis].	0.00494283
NZ_AP018203.1|WP_017287751.1|3114859_3115777_+|hypothetical-protein	gnl|CDD|277324	cd07378, MPP_ACP5, Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain. Acid phosphatase 5 (ACP5) removes the mannose 6-phosphate recognition marker from lysosomal proteins. The exact site of dephosphorylation is not clear. Evidence suggests dephosphorylation may take place in a prelysosomal compartment as well as in the lysosome. ACP5 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.83805e-39
NZ_AP018203.1|WP_017287747.1|3109575_3111264_+|serine-protease	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.80087e-23
NZ_AP018203.1|WP_017287756.1|3119987_3120305_+|PqqD-family-protein	gnl|CDD|377508	pfam05402, PqqD, Coenzyme PQQ synthesis protein D (PqqD). This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis.	1.07027e-15
NZ_AP018203.1|WP_017287755.1|3118278_3119919_+|lasso-peptide-biosynthesis-B2-protein	gnl|CDD|379721	pfam14907, NTP_transf_5, Uncharacterized nucleotidyltransferase. This family is likely to be an uncharacterized group of nucleotidyltransferases.	3.58056e-50
NZ_AP018203.1|WP_017287739.1|3102493_3103756_+|HD-domain-containing-protein	gnl|CDD|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	1.41587e-94
NZ_AP018203.1|WP_017287760.1|3123459_3124341_+|hypothetical-protein	gnl|CDD|238899	cd01918, HprK_C, HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent phosphorylation of Ser-46 of HPr and its dephosphorylation by phosphorolysis. The latter reaction uses inorganic phosphate as substrate and produces pyrophosphate. Phosphoenolpyruvate carboxykinase (PEPCK) and the C-terminal catalytic domain of HprK/P are structurally similar with conserved active site residues suggesting these two phosphotransferases have related functions. The HprK/P N-terminal domain is structurally similar to the N-terminal domains of the MurE and MurF amino acid ligases.	2.27608e-07
NZ_AP018203.1|WP_017287740.1|3104008_3104656_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.64714e-43
NZ_AP018203.1|WP_017287738.1|3101230_3102469_+|PDZ-domain-containing-protein	gnl|CDD|177681	PLN00049, PLN00049, carboxyl-terminal processing protease; Provisional.	1.31495e-147
NZ_AP018203.1|WP_017287757.1|3120308_3122174_+|asparagine-synthase	gnl|CDD|238364	cd00712, AsnB, Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a synthetase domain. The N-terminal glutaminase domain hydrolyzes glutamine to glutamic acid and ammonia.	3.77618e-30
NZ_AP018203.1|WP_017287752.1|3115773_3116412_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.95544e-16

Protein sequences

>NZ_AP018203.1|WP_017287747.1|3109575_3111264_+|serine-protease
MARIGWIVGLFSGITLAFSQASITLAKAVLSPSEIRQTAQPLTVQILGFSPEGSQTGSGVIIAKQGNTYAVLTNRHVICNLDFAGQCDRNLRLQIRTANGQRYPVANTHTFEQLKGIPDVAVVLFQSPQNYPVATFGDSTQLAKRDLIWINGYPGSPQQSPGTEPVAFHKGFFTSQVNDPHSEGYSLMFTTIAAPGMSGSPIFDASGRVIAIFGQSGDMGVLAGIPSNFVSDLLQKSSKLNQMTLTVDRSALTGTRPQLSTPQTAEDYFLRGVSQIDQPQSALADLTKAIELNPKLMMPYRTRATIRARMGDQQGAMRDFETVLKLNPDRSDALSARAQMRIQWNDLTGAIADYTEALQHAPQTPSLLFNRGMTHSRLGNYQASVDDFTAGIVLQPKDAVAYRERGRSYLGLQQLPSALKDLDRSIALDPSSAVAYDLRCFIQMGMDRYQAALNDCNRAIEINPTYAIAYADRAFAWLGLNNPQNAIQDAKTASRLDPKLSESYTVQAMAYERIGDLQNAIVAYEAVMNLLRENGQINSRAYQGISATIAQLRSKVKSQESR
>NZ_AP018203.1|WP_017287746.1|3108121_3109204_-|hypothetical-protein
MAQPILYLAITNHGFGHATRAAAIAAEIQRLDPEIVLILATTAPRSVLEAYIPGDFIHRPRALDVGIIQQDSLIMDKPATLEKLREIRSRQQATIASEANFILQNKAGLVLGDIPPLAAPIAKAAGVPGWMMSNFGWDFIYRDWGGEFLEMADWISDCFSQCDRLFRMPFHESMQAFPTVTDVGLTGVAPRFEAAEVLAKFNLTDTPKEKIILVTFGGLGLDRVPYENLTHLSDYQFLCFDNNAPDLPNLIKVDDRFYRPIDLMPICGRLLSKPGYSTFSEACRYEIPVMTVTREGFAESPILLEGIQDYAEHQIWSLDEFFNGDWSNIRQPMNPPRKSEKLPKDGNLTIAQAVVDYLRS
>NZ_AP018203.1|WP_017287745.1|3107059_3107953_+|hypothetical-protein
MKKIVSLMISVIVLTLSGVRSTQAQVLEFTPNLPKSEVKKSPKIQESTPSEIQESPSSKTQASSPAILTPLKPSSPPQPQPKPQNIDTSTDDTRLVAVAPDELFAGGSDSLVARAVGSAEGTRTPEGGKTWAYYGHVDPGNGAWNMGSFSYQHGASSPDDADRRQLDRLWRQYQVIQESAIAAGLRLGLEEQLNGIDLANQAPLAALDEGGYVDRLRQAYERGFRGSEAVLQARTYSYLNPRTNRWEAPGLGNTLEGISRDQARRQGAIAEAMSYHQQSQVARSRTSDDERVSAVPK
>NZ_AP018203.1|WP_017287744.1|3106640_3107063_+|hypothetical-protein
MLLLLISGCTSSQQPNHSISEPKLYQSWQLKLGDQIAGSTVIGGLGDISIALNGKSVYAPSTGNVYLGQRGCVYFAGTDTPAYLFRLCGLKSPKLGALKAGDAIATGDILQFATLLKQSDGTWALVEPDKSLLERTLKPR
>NZ_AP018203.1|WP_017287743.1|3106228_3106624_+|hypothetical-protein
MIDKLNSNQFLASIAGVLAIGIFIQAMGLPSFGSKEATLECQGTVRSDSALAKDKIANLIQFKTGDTKDSVRKVLKEPYCVLPKIAIRSGMQTEREAYRVASDALEKSTSQTFIVVSYEGDQYLGYKFWIR
>NZ_AP018203.1|WP_017287742.1|3105386_3106232_+|hypothetical-protein
MTELKTESQSTRIVQTQPTARRQSKKSAIAAGKESPSEAPAESNTEDIAKKTSRTTKTKKTTQTRQAASKSTNQSASTRVKLTWEPSPSIEASLQQFNEQLNATWMAIDELKATVEQMQIQTARPASVQLPLEPPKAQMSDVAPHQPAQSVPVPRTRARVPETAPQSAIPPFRPTSGFPTSVRVRRRKPFDLLMQSVLRLPVQNSGIAIDAALWVMAAAGLRVGLKYVVMAFPVLELPVMILVFVPALLAAYAALFIPNVNRIGVYRLLLLALGLFVGGRL
>NZ_AP018203.1|WP_017287741.1|3104722_3105160_-|hypothetical-protein
MGITTQIEIIQLQSIKGGMAEFYTPQSSHETMLVNVPANTIDDLFVHRTQTDQLLVVRGSFILVVLQNRKYEYIPLSESYPQVVKIPPGVPHGAINLSDSPCVLVNAVLRHRPAIEQDYRPMRRPIPYDIDIAHQLQEFLRPSAA
>NZ_AP018203.1|WP_017287740.1|3104008_3104656_-|response-regulator-transcription-factor
MPLTILVAEDDVGTRLSISDYLECSGYSVVSAENGADAIALLDTHQPHLIVTDVSMPLIDGYELVRHVRRRPALRLLPIVFLTGRTETTERVKGYQLGCDVYLAKPFELSELGAVVRNLLDRTQMIETEWRSRQGFEASGEIGEKPIADIDIALTDREKQVLALLSDGLSNIQIGNHLHLSARTVEKHVSSLLRKTETSNRAELVRFAMEHHLVV
>NZ_AP018203.1|WP_017287739.1|3102493_3103756_+|HD-domain-containing-protein
MVERVYHDPLHGAIALDQSDPTEALLIQLIDTPAFQRLRRIRQLGPASLTFHGAEGSRFTHSLGVLAVARRAFDRIARDYPQLLPHRTIVLCAALLHDIGHAAFSHTAEEIFGSDHELWTRRILRESEPIRQLLDRFSPDLIDQLEAVFLKKYPLPLVWQLVSSQLDCDRLDYLMRDSYFTGASYGHIDLDRILMAMRYDPVTQQLVVAKKGMAAIEHYLIVRYFMYSQVYNHRKNIAATWVLLKTFQQARYQLKLGNLEADQNVRAWLNQDGNQIELDQYLAGDDGAFLYHFQQWRSHSDPVLADLSRRFLDRDLLKSLDISQLEESDRDLLLEKARYWTTQAGFDSSTYCGLRIAVSRGYTLYDRGIHIQTTTGLREIGELSALVQTLTQPIQKVWLIYLREIDDKIKSFVDKAGELL
>NZ_AP018203.1|WP_017287738.1|3101230_3102469_+|PDZ-domain-containing-protein
MEKRFIWVRSLTIVGLSIAAALLFLAAPALALTEEQKLINEVWRIIDRGYVDPTFNHKNWWALREKYLKQSLPNREATYGVISQMLAVLDDPFTRLLKPDQYRSLQTSTSGELTGVGLQIALDMETKRLKVISPISGSPAAKAGILAGDSILEIDGVTTEGLSLDEAAEKMRGTIGSHVMLTVKRETEEREFDLVRARVELNPVVAELRSQPNGLKVGYLRLSQFNANAAMELGHAIASLEKNGADHYILDLRNNPGGLLNAGIEIARLWLDEGAIVYTVNRQGTLGSFEATGKALTHDPLVVLVNQGTASASEILAGALQDNARATIIGEKTFGKGLIQSLFDLSDGSGLAVTVAKYETPNHTDINRLGIQPDRVVPIDQTFTLEQIGTEADRQYQAAIAAFSDSLVAGAK
>NZ_AP018203.1|WP_017287751.1|3114859_3115777_+|hypothetical-protein
MRLSRRQLLVLGGVGAAGLAVAGKSFSRQFEPMPQTVSEPPKPASQELMLRFVAVADSGAGDQNQFDSANAMANYHKKHPYSLVTLAGDNIYNSGEMERIGIAFEQPYAPLLKQNVRFQACLGNHDIRTANGDPQVQYKNFHMTGRYYTYREKDVQFFVLDTNGNADWKDQMAWLNAELGRSNAPWKIVYGHHPIYSSGHYGTDREMIRKFAPLFKKHQVQLYINGHEHHYERSTSIDGTTYLVTGIGGASLRPVGTSKTTEYSVSRFGFSAIEVYPDRLQIEGIGTDGLVFDRGIIARQAQVAV
>NZ_AP018203.1|WP_017287752.1|3115773_3116412_+|class-I-SAM-dependent-methyltransferase
MTDASTRTVQLATDFIGKGDPLGWFEELYATANGDPTTVPWARLTPHPLFVEWLNQHSLVGKTAIVIGCGLGDDAEELAKRGMEVTAFDISETAIAWCKKRFPDSSVNYQVADLFQLALGKFDFVLESYTIQAMPPELRAQAIPKIAELVAESGQLLVICLGREPEQPLATVPFPLTKIELSGFTQAGLHEVKFEDLNEPETVRRWRVQYQG
>NZ_AP018203.1|WP_036045731.1|3116425_3117091_+|ABC-transporter-ATP-binding-protein
MIWMEDITKTYRLGEVDVPVLKGIDLAIEEGEYVAIMGMSGSGKSTLMNIIGCLDRPSDGNYVLEGRNLTTLDNDELAFIRNQRIGFVFQQFNLLSRATALENVMLPMVYAGVARSQRKRRAEEALTRVGLAERLSNRPNQLSGGQQQRVAIARALVNRPALVLADEPTGALDTQTSAEVMALLTELNQQGITIVIVTHEPDIAAQTQRTIHVKDGLVVDG
>NZ_AP018203.1|WP_017287754.1|3117252_3117957_-|thiol:disulfide-oxidoreductase
MLDLYYWTTPNGHKITIFLEEVGLPYNLVPINIGKGDQFQPEFLKVSPNNRIPAIVDHEPADGGEPISLFESGAILLYLAEKTGKLIPSDLRGRADTLQWLFWQMGGLGPMAGQNHHFSQYAPEKISYAINRYVNETGRLYAVMNKQLSDREFLAGEYSIADIACYPWIVPYERQGQKLEDFPNLKRWFETIQSRPATVRAYEKAEAFKADQISPEQARELLFNQSAGTVKPAS
>NZ_AP018203.1|WP_017287755.1|3118278_3119919_+|lasso-peptide-biosynthesis-B2-protein
MSPLSQDTFAPLSSQDDLELALLLCCARTHRDATTVAQIHQLVHQPIRWENLIPLAEWHSVLPLVYQTLNTVCPEKIPPEISKRLRQSFYAISLNNQLLIQTLLILLKQFEDAEIPVLAFKGPLLAISYYGDLNLRQFNDLDLLVARNDFERAQTLLREKNYQPYQVLGWQTAFAHSSSGVGIDLHRALTPPYFKFDLQFEELRSRLQSCSFDNQQIACLSPIDMLLILCVSFCRDRHEQKSRLIQLCDIAQLIQAYPNLDWHQVLNQSRRFGILHMVLVTLALGQQLLQIPLPKMMQTQIQHNSAIESLLHPLATNLLKTNLQPQLLQFDSETFCLDHTFYLALRERWSDKIPYFLNYAALPVDHLQRIQLPKAFDHLYLIRRTIGPKTNLFRLKVLLHRVKLFLRLSPQDSIRFICALALFPCIAIALQHWNIAQIQGVLTRLCRPLSPASPVQVARTVRLVEIAARQYSSRWANCLKRSLVLWYLLRCQGIASELRIGVRREQGEFQAHAWVECQGKILNDIPDVHQSFAAFDSTLMHKLSSD
>NZ_AP018203.1|WP_017287756.1|3119987_3120305_+|PqqD-family-protein
MLKHPQITLTDSLLNQQKYQIADDVLYRQVDTEAILLSISGGAYYSLNETSIYIWDALKNQQPLASAVDRILDEYDVERTQVLTDLQQVLQDLSAYGLISPVNLE
>NZ_AP018203.1|WP_017287757.1|3120308_3122174_+|asparagine-synthase
MSGILGIWNSQQPSPWEAMLSDLTVLGRDGQGSWHDPSIGLSLGRSQLFNTPESCLEAPVVEQDGCVLVWDGRLDDRETLLAGRTQVPDAQLIIESYRRWGVDSLRHLVGEFVFILWDASQDLLFVGCDPVGNRTIAYVWDGNTLLLCSRVLTLLLHPQVSHEFDEGYMAHTICDAWAHPAEITPFQAIKRLRPGYGLILQSGRLQQRQLAKLAPTSYDLRDSPETYFEKFWYLLNQSVRDRLRNYRPVCTTLSGGLDSTTVTVALLNHLSNLEAFSVTTERYAAIDESEPIQAFLDRYSQVKWHSINCDDAWVLSEPWEQLPLPDDPFTSCVVPMHLRMMQEAQKLGFGLIFDGEWGDEFCYIFWRDRIQVGDWQFLWQQLRSPGNRRSFVLQDLILPNCPKPWQTQWMMSRLKLRNLAPQWIQSTYLAQIQQTQVAEQLAMKSFGLDRVKALNQEIEDASFVGTMQVHRLLRSAHQLEYTSPLRDQRVVEFANRLHPSLQLDSNYQKVFLRHANRTTLPDAVRLRPKINYFDPLKYAGLGRGSQALELLEQAKQNSYLQEAIDFKQLENSLLSYRQSYEQDYRPDEPFHDGIANQLISTLGLANWLTQLDKKYLARKVI
>NZ_AP018203.1|WP_017287758.1|3122173_3122947_+|hypothetical-protein
MMIKIHKQSYRYFYQLIDLLTACFVGFWLGVLDRNSMYQIDQQFYDSEAIYRDEEYNQSGFWEWEFKAIQTHFKTCKTILLAGAGGGREILALHALGYEVDAFECNPNFVKFANEFLQEKQINCTVQIAVRDTCPVYEEIYDGLIVGWGAYTLIQGRQTRIDFLKQMRDRVKSGSPILLSFLYAYKPAKYYKMISTIANLIRAIRWQSKTEIGDFILPENFVHYFSKEQISSELKEAGFRLEFYSELNYGHAVGIAE
>NZ_AP018203.1|WP_017287760.1|3123459_3124341_+|hypothetical-protein
MKFQSILQAATDELRHISNTQLTLELVTELPLNSGAGSIYKNSSAQNTSHHYWIPWTEEMGAWIDANGHHAILVVVESAPIENIQGSPVLCFAAHIAATCLGLQGQIALHANVVALDGVAIAFAGCSGKGKSTLTTYCVSRGASFVTDDVLVVNDQGQVRPGSPRIKLFPHTGESFGLDASETTTYKIHYAIEQLGITPQNQSFPLGTIYLLEESDRIYIEQLSPSQALLDLLIHSYHVTEIMPDQPSLFYAYTNLVAQVPVKKLFYPRSFESLPKLYDFLQTETHSFTPQLL
>NZ_AP018203.1|WP_017287761.1|3124337_3125459_+|methyltransferase-domain-containing-protein
MSYLLLQGQQVMTLDARRNAAYLQAMQAVITPDSVVLDLGAGLGIFGLLAAQLGAKRVYMVEPEDIISLTQQIVKANGYSDRIQCLQGKIEEVTIPEPVDVIISVFTGNFLLSEDLLPSLFYARDRYLKPSGVLIPSAAVMETVPASVPAFYEREIAVWSNPHLNLDHSPVRSYVSQAMFFARQDLGQAQYLAEPEKVMALDFYQATDTNCRAEIHHTITQAGICHGWIGWFKMLLGDQWLSTAPHEPPLHWSSAFMPIDPPVAFEVGETVTFKLQRPPYGDWIWQFKSQQTQQQRSTFFSVPNTLKTLQKMAPAYQPNLNTKGKAVHYILAHADGTHSVQELAQQLVSLFPDTFATDQKATKFIQTLVSWLA

Crispr_ID: NZ_AP018203_8

• CRISPR_ID: NZ_AP018203_8
• CRISPR_location: 3160491-3160570
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_8

Consensus_repeat	Method
GCGCGAAAATTCTGGAGCCGCGA	CRISPRCasFinder

spacers of NZ_AP018203_8

>8.1|3160514|34|NZ_AP018203|CRISPRCasFinder
CAGGAGTTGCGATCGCAGGAACGAGTTGAGCGGA

CRISPR arrays and Neighbor proteins around NZ_AP018203_8

CRISPR arrays

The CRISPR arrays of NZ_AP018203_8

>merge|NZ_AP018203|8|3160491-3160570|CRISPRCasFinder
GCGCGAAAATTCTGGAGCCGCGACAGGAGTTGCGATCGCAGGAACGAGTTGAGCGGAGCGCGAAAATTCTGGAGCCGCGA

>NZ_AP018203|8|8|3160491-3160570|CRISPRCasFinder
GCGCGAAAATTCTGGAGCCGCGA	CAGGAGTTGCGATCGCAGGAACGAGTTGAGCGGA
GCGCGAAAATTCTGGAGCCGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_086371027.1|3147246_3149685_-|phosphoenolpyruvate-synthase	unknown	unknown	gnl|CDD|235809
NZ_AP018203.1|WP_017287786.1|3154911_3155571_-|deoxyribonuclease-V	unknown	unknown	gnl|CDD|236937
NZ_AP018203.1|WP_017287781.1|3150904_3151822_+|NAD(+)-kinase	unknown	unknown	gnl|CDD|179455
NZ_AP018203.1|WP_017287799.1|3169586_3170498_-|branched-chain-amino-acid-transaminase	unknown	unknown	gnl|CDD|235841
NZ_AP018203.1|WP_017287795.1|3166223_3167693_+|glycolate-oxidase-subunit-GlcD	unknown	unknown	gnl|CDD|273050
NZ_AP018203.1|WP_017287787.1|3155606_3157871_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380492
NZ_AP018203.1|WP_017287783.1|3153075_3153918_+|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320690
NZ_AP018203.1|WP_017287798.1|3168563_3169454_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|215315
NZ_AP018203.1|WP_017287791.1|3161854_3162877_+|VCBS-repeat-containing-protein	unknown	unknown	gnl|CDD|379232
NZ_AP018203.1|WP_017287784.1|3153951_3154491_+|DUF456-domain-containing-protein	unknown	unknown	gnl|CDD|225395
NZ_AP018203.1|WP_017287782.1|3151818_3152919_-|glycosyltransferase	unknown	unknown	gnl|CDD|340839
NZ_AP018203.1|WP_017287790.1|3160930_3161719_+|isochorismatase-family-protein	unknown	unknown	gnl|CDD|163356
NZ_AP018203.1|WP_017287796.1|3167796_3168039_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287800.1|3170699_3172415_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl|CDD|225387
NZ_AP018203.1|WP_017287793.1|3164536_3165133_+|hypothetical-protein	unknown	unknown	gnl|CDD|380190
NZ_AP018203.1|WP_017287794.1|3165181_3166093_-|hypothetical-protein	unknown	unknown	gnl|CDD|275040
NZ_AP018203.1|WP_017287788.1|3158050_3158398_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017287792.1|3162962_3164432_-|9,9'-di-cis-zeta-carotene-desaturase	unknown	unknown	gnl|CDD|131779
NZ_AP018203.1|WP_017287780.1|3149966_3150644_+|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|380324
NZ_AP018203.1|WP_017287778.1|3146481_3147168_+|manganese-catalase-family-protein	unknown	unknown	gnl|CDD|226076

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_086371027.1|3147246_3149685_-|phosphoenolpyruvate-synthase	gnl|CDD|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	0
NZ_AP018203.1|WP_017287786.1|3154911_3155571_-|deoxyribonuclease-V	gnl|CDD|236937	PRK11617, PRK11617, deoxyribonuclease V.	8.85145e-121
NZ_AP018203.1|WP_017287781.1|3150904_3151822_+|NAD(+)-kinase	gnl|CDD|179455	PRK02645, ppnK, NAD(+) kinase.	0
NZ_AP018203.1|WP_017287799.1|3169586_3170498_-|branched-chain-amino-acid-transaminase	gnl|CDD|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	3.66328e-164
NZ_AP018203.1|WP_017287795.1|3166223_3167693_+|glycolate-oxidase-subunit-GlcD	gnl|CDD|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	0
NZ_AP018203.1|WP_017287787.1|3155606_3157871_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380492	cd06268, PBP1_ABC_transporter_LIVBP-like, periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.	8.16013e-69
NZ_AP018203.1|WP_017287783.1|3153075_3153918_+|M48-family-metalloprotease	gnl|CDD|320690	cd07331, M48C_Oma1_like, Peptidase M48C, integral membrane endopeptidase. This subfamily contains peptidase M48C Oma1 (also called mitochondrial metalloendopeptidase OMA1) protease homologs that are mostly uncharacterized. Oma1 is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins; it cleaves a misfolded polytopic membrane protein at multiple sites. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Oma1 is part of highly conserved mitochondrial metallopeptidases, with homologs present in higher eukaryotes, eubacteria and archaebacteria, all containing the zinc binding motif (HEXXH). It forms a high molecular mass complex in the inner membrane, possibly a homo-hexamer.	1.23899e-53
NZ_AP018203.1|WP_017287798.1|3168563_3169454_+|alpha/beta-fold-hydrolase	gnl|CDD|215315	PLN02578, PLN02578, hydrolase.	3.37057e-78
NZ_AP018203.1|WP_017287791.1|3161854_3162877_+|VCBS-repeat-containing-protein	gnl|CDD|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	1.36171e-06
NZ_AP018203.1|WP_017287784.1|3153951_3154491_+|DUF456-domain-containing-protein	gnl|CDD|225395	COG2839, COG2839, Uncharacterized protein conserved in bacteria [Function unknown].	1.59132e-17
NZ_AP018203.1|WP_017287794.1|3165181_3166093_-|hypothetical-protein	gnl|CDD|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	5.57347e-33
NZ_AP018203.1|WP_017287790.1|3160930_3161719_+|isochorismatase-family-protein	gnl|CDD|163356	TIGR03614, RutB, pyrimidine utilization protein B.	2.61552e-43
NZ_AP018203.1|WP_017287800.1|3170699_3172415_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl|CDD|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	2.98114e-117
NZ_AP018203.1|WP_017287793.1|3164536_3165133_+|hypothetical-protein	gnl|CDD|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	0.00113674
NZ_AP018203.1|WP_017287782.1|3151818_3152919_-|glycosyltransferase	gnl|CDD|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	4.68648e-71
NZ_AP018203.1|WP_017287792.1|3162962_3164432_-|9,9'-di-cis-zeta-carotene-desaturase	gnl|CDD|131779	TIGR02732, Zeta-carotene_desaturase, 9,9'-di-cis-zeta-carotene desaturase. Carotene 7,8-desaturase, also called zeta-carotene desaturase, catalyzes multiple steps in the pathway from geranylgeranyl-PP to all-trans-lycopene in plants and cyanobacteria. A similar enzyme and pathway is found in the green sulfur bacterium Chlorobium tepidum.	0
NZ_AP018203.1|WP_017287780.1|3149966_3150644_+|NAD(P)H-dependent-oxidoreductase	gnl|CDD|380324	cd02149, NfsB-like, nitroreductase similar to Escherichia coli NfsB. NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.	3.2011e-65
NZ_AP018203.1|WP_017287778.1|3146481_3147168_+|manganese-catalase-family-protein	gnl|CDD|226076	COG3546, COG3546, Mn-containing catalase [Inorganic ion transport and metabolism].	5.3618e-93

Protein sequences

>NZ_AP018203.1|WP_017287788.1|3158050_3158398_-|hypothetical-protein
MSKKKFALGLIAGFGIAMIAAPSHAQQAPSSADLLRDPQSQDSLSNLFNNRGDNATSSLMDLIQRVSQGSVDPEAFRQQQRESLDAATAEFLNKRRQMLQTQPQVAPAPVVQPLN
>NZ_AP018203.1|WP_017287787.1|3155606_3157871_+|ABC-transporter-substrate-binding-protein
MPLSLFRAAMLGRILDARYKILQPLGSGGFGQTYIAEDTKRPGNPRCVLKHLSFSSQDEAILRQVRRMFFAEAETLERLGRHDQIPRLLAYFEEDQEFYLVQEFIQGHPLSEEIGGDRRLAEAQVVDLVEDVTQVLGYVHEQGVIHRDLKPENLIRRDRDQKLVLIDFGAVKTILESSIATEPVDLSVPIYTSGYAASEQCLGQPRYNSDFYSLGMIAIQALTGVRPSQLAYDPNTHNLLWRDRVTVSHDFAAVLEKMTQFHFNDRYQTAAEILEALNQVKSSIFTQMPISEAKNRLRSPQPVLNKPLKMSAIAAGLTAIIGASAWTLTRNTPTPTDPPGQRGQFLSVGQTLLSPNTPPQPLKQAAIDKMKSGEFAEAVSLFEQAHKIDQSDPETLIYLNNARIGSEQANTIAVVLPIRTNPTASAEVLRGIAQAQDRINQTKAMKLKIAIASDDANPDLARQIATQLVRDPTVLGVIGHGTSDTTLAAGKIYQEGELVAISPVSSAKNLSGFSRYVFRTMPSDELPAKRLVSYMTKQLKKRKAAVFFNSKNLYSKSLTEAFKDALYYADKGKVVHEVDLSNPAIEVAENVAQAMKKGAEVIFLAPNAELLDRTLLIINANQKRLPILAGDALYNSRILTELGSAASEMVVAIPSAQTQLQNSPFEQQAKSVWGRAPGWRSALGYDATQAMIAALQKAPTRNGIRATLSTPSFTTIGAVQSVSFTPEGDRETEITLVRVTGAKSGKFIFQPIPK
>NZ_AP018203.1|WP_017287786.1|3154911_3155571_-|deoxyribonuclease-V
MKIEQRHEWVLTAEAAIVIQQELSQEVITDDQFGTVNYVAGIDVGFEAEGTITRAAVAILKYPELEFCDHAIARRPTTFPYIPGFLSFREVPAVLDALEQVKTSPDLLLCDGQGLAHPRRFGIACHLGILTNLPAIGVGKSRLVGKHEEPPDQRGAWVPLIYKGNTIGAVLRTRPGTKPLYISSGHRIRLESAIAYVMGCTTKYRLPETTRHAHKLASG
>NZ_AP018203.1|WP_017287784.1|3153951_3154491_+|DUF456-domain-containing-protein
MELTVLYWILVAVMVVGVVGAVVPGIPGPSLILVAILLWCIVTKFAIPLLPLGLIFVALLLSSVVEWLGSYWGAKQIGASRWSQMGMFIGMAIGFFGLLPALPLGGPIAGILVGGLLGGFIGEFLYRSDLPTSERLRTAGRVTLGIGFGALIGNLIELVLAIAAVAVFVWVTLPSVMWT
>NZ_AP018203.1|WP_017287783.1|3153075_3153918_+|M48-family-metalloprotease
MSVLIRLILGLIFAIGGLFSYYGNTSQNPVTGENQRVQLTPRQEIVLGLQSRQQMAARHGGLFPDQGLQTYMDEVGQRIVQRSDASKSPYTYEFHLLRDPKTVNAFALPGGQVFITAALLGQMKSEAQLAAVFGHEIGHVVGRHGAEHLAKQQLGSALVTAVGVAASGGQDGGQGAAAIAQATNQLVNLRYGRNDESESDRLGLKFMLDAGYDPRGILEVMQILAKSAGSGRQPEFLSSHPDPGNRLQALKAAIQKQFPQGLPRDLEDGRDRFAQAVLRR
>NZ_AP018203.1|WP_017287782.1|3151818_3152919_-|glycosyltransferase
MSDRIAILLAGNKMTGDTRVIFNLAEGLIARGFEIDLLLASSAQFVLSDLSKQVNVIDLQTPVTARTSSMIKLLFPLLHYLRRVQPKTLISNLCFANAIVTLSKFLTFPAPKLVLVEHLALSTDEHDGEPHSKLLPLLIRVLYPHADAVISVSQQIGAELRSKYNLTNVLAIANAVVNSRLTEQAQSDLDHPWFASDEIPVFLGAGRFAAQKDFTTLIRAFSILRQEMPARLVILGDGALRSQLEAQIQSLGLQADVELPGFVYNPYQYMSRATAFVLSSRWEALPTVLIEAMACGCQVIATQCRSGVDEILSGGEFGQIVPIADPVAMAAAMKNSIQHPISPRLLKFRADDFSIEQAVDRYLEVI
>NZ_AP018203.1|WP_017287781.1|3150904_3151822_+|NAD(+)-kinase
MQLKQVLIIHKSGDALSQRWAKKCAEALEKRGCNVLMGPSGPKDNPYPVFLASVSLPINLAVVLGGDGTALSAARNLASDGIPILAVNVGGHLGFLTESPDDFDSETIWDRLEADRYAVQTRMMLQATVHEGNRTNLEPVSDRFLALNEMCIKPASADRMITSILEMEIDGEVVDQYQGDGLIISTPTGSTCYTVAANGPIIHPGMAAISVTPICPLSLSSRPILIPSGSVVSIWPLADYDLSTKLWMDGVLATSIWPGQRVDIRMAAEEARFIVLRENYSYYQTLREKLQWAGARIHYHNNHRN
>NZ_AP018203.1|WP_017287780.1|3149966_3150644_+|NAD(P)H-dependent-oxidoreductase
MAGFMSTTSEIASPQFALEHLQWRYATKQFDPAKKIPTETWNVLEQSLVLSPSSFGLQPWKFLVIRNLELRQQLLEHSWGQKQVVDASHLVVFAIQKNIDAAYVDRYIVRMAEVQQVPVESLQGFAKVVKGFLDQRPSPSDVQAWATRQVYIALGQFMTTAAMLEIDTCPMEGFVPAKYDEVLGLSEQGYASVVLCPTGYRSAEDKYAAKPKVRFATQEVVQNLD
>NZ_AP018203.1|WP_086371027.1|3147246_3149685_-|phosphoenolpyruvate-synthase
MLEAQVSNSLINESTKAQALVLPFQQVGIADIPIVGGKNASLGEMIQQLTSKGVNVPNGFATTAFAYRSFIAGAGLETQLRQLFADLNVEDVQNLQERGRKARSLILQTPFPVELEQAIANAYQTLCEEYGTDTDVAVRSSATAEDLPDASFAGQQETYLNIHGLPSLLEACHKCFASIFTDRAISYRQLRGFDHLEIALSVGVQKMVRSDLAASGVMFSIDTETGFRDAALITAAYGLGENVVQGAVNPDEYVVFKPTLKQGYRPILDKRLGSKEIKMVYDLGGTKSTKNRSVSLEQRQQFAIADEEILQLANWACIIEDHYSQVRGVPTPMDIEWAKDGITGELFIVQARPETVQSQKTQQILRTYRLVATPPEPMITGRAVGEMIGQGKARVILDVHQLDQFQTGDVLVTNRTDPDWEPIMKKASAIVTNQGGRTCHAAIIAREMGIPAIVGCGNATTQIYTGQTITVSCAEGETGRVYAGMIPFEINEVELETLPQTKTDILMNVGNPQEAFSLAAIPNDGVGLARLEFIIANQIQTHPLALIYFDELDDRVAQAQIAALTPGYDDKSQFFVDKLAYGIGTIAAAFYPKPVIVRMSDFKSNEYANLLGGRQFEPREENPMIGWRGASRYYDERYQEGFALECQAMKRVRDQMGLTNVILMIPFCRTPEEGKRVLAEMAKYGLTRGENGLQVYVMCELPSNVMLATQFCEVFDGFSIGSNDLTQLTLGLDRDSSLVAHLFDERNEAVKQMVGLAIAKVKRCGRKIGICGQAPSDYPEFAKFLVQQGIDSISLNPDSVLKTRMAIAQAEQ
>NZ_AP018203.1|WP_017287778.1|3146481_3147168_+|manganese-catalase-family-protein
MFFHKKESIHTVNVDDANPKFAQLLLEQFGGATGELTAALQYWVQSFHCENPGIRDMLQDIAIEEFGHLEMVGKLIESHTKNVDQTEAYKSSLFAVRGMGPHFLDSQGSAWTAAYINEGGDVVRDLRANIAAEAGARQTYEALIKLAPDKGTEKTLVHLLTREISHTQMFMKALDSMGKLTDPMFGNIQPDETVDIYYNLSQNGQDQRGPWNSEPTFKYIADPMSQQS
>NZ_AP018203.1|WP_017287790.1|3160930_3161719_+|isochorismatase-family-protein
MNEPMYPLGLPPNAWYVNSTIADLTRSPIPPQIITVETATKKIRLDLNKSALIVIDMQNDFCHPDGWLAHIGVDVTPARSPIVPIQQFLPIARQVGLSIVWVNWGNRPDLLNISPATRYVYNSDGQSVGLGDPLPKNQAPVLQKDSWAAAIVDELQPIEGDIQIDKYRMSGFWDTPLDSILRNLGKTTLFFAGVNADQCVMATLQDANFLGYDCILLEDCTATTSPDFCWQATLYNVKQCFGFVSSSISVLNGIKSGVKDKN
>NZ_AP018203.1|WP_017287791.1|3161854_3162877_+|VCBS-repeat-containing-protein
MTFFDSLNSFKAPDFNGDGRTDLFSFDLTTRIPEINLSANIRTSASSPIFFIPEGWQTPKYGDFNQDGKTDLVWRNPKTGENAIWLMDGTSSLDAQWLDSLQGTWTEVIGDFDGNGTSDLFWYNSTTGEFQIWAMNGAQRVKRSIAQIEPGWEPAAVNFISDHRHELFWRNPLTGQNAVWTIDPQTLSTSGEWIETKSPTWNYEMIDYNGDGRSDLFWRDRLTGQNQIWLWTSDSLQPDPIAIDLPSTSRDFVIKTGDFDGNHKTDFLVRNPSTGENQIWRAGDIEVQISDIPAQSATFFPEIGDYNGDRFSDIRWVSVTGQENVIWFSDGKLPQSIATE
>NZ_AP018203.1|WP_017287792.1|3162962_3164432_-|9,9'-di-cis-zeta-carotene-desaturase
MRVAIVGAGLAGLAAAVELVDAGHEVEIFEARSFVGGKVGSWIDADGNHIEMGLHVFFNNYANLFALMKKVGVYQELLPKEHVHTFVNRGGELGKLDFRFLVGAPFHGLKAFFTTGQLTIQDKLQNAIALGTSPIVPGLINFDAAMKMIRALDGVSFADWFRSHGGSQNSLKKMWDPIALALGFIDTENISARCMLTIFMMFAAKTEASQLNMLSGSPAEYLHKPIVDYLEARGAKIHTRRQTRRILFEGEGTNTTVTGLAIANGETEEIITADAYLAACDVPGIQRLLPQEWRSIKEFDNIYKLEAVPVATVQMRFDGWVTEMNDPAARKQVDHAAGIDNLLYSSDADFSCFADLALTSPKDYYREGQGSLMQVVLTPGDPFVPMSNEDIAQHALKQIHDLFPSSRELNMTWFNVVKLAQSLYREEPGKDPYRPSQKTPIENFFLAGSYTQQDYIDSMEGATISGKQAAQKILEPTGYKVQGVGLFKY
>NZ_AP018203.1|WP_017287793.1|3164536_3165133_+|hypothetical-protein
MVKVLLLVAMLGFLTSCTPLPTKIRAYVESRPVDPTPYEKQGLVAVQPDAPKPSGSEIKLPPTVTVKPGQKLSEEEIKTLLTQADDKAASAANLSRVAQSKDDWRLVIDRWKLAIDILKPAAQIPRIRKQLSEYQTNLTAAQVQASTNPRQIEATERSTSDGIPLTIQAPSPSPSPSASPSPTASPSSTASPSPSPSP
>NZ_AP018203.1|WP_017287794.1|3165181_3166093_-|hypothetical-protein
MTVLILGHAADLHASHLYQTLERLGIVCHYWDVATFPTQAQITWSPVSQEGLLRLADGRHLAVSQIRSVFWRHFAGVRVPRLPHASVQKAAYQDAIALVRSLIQIPSIHWVNPIQAYQLHREKPLQLSKLHQLGVNLPDTIVTNDPTSVREFVYRHSKTTFKPIYGGARTQLISAEHLNPERLKLSLKIAPVTLCEYIAGANIRSYVIGDTVYAAEICSAALDFHEDDDVKVIPIIFPKAMCQQAIAIAQALDAEWLMIDWRLTPSGKYLFLEANPNPSFLAFEQQTGFPITQALIELLLNSD
>NZ_AP018203.1|WP_017287795.1|3166223_3167693_+|glycolate-oxidase-subunit-GlcD
MTAVVTQPNWQAIAREFEAVVGKSGVVQRREELLVYECDGLTSYRERPAIAVLPRTTEEVAEVVKICARASVPFVARGSGTGLSGGALPIENCVLIVTSLMRKILQVDLENQRVIVQPGVINSWVTQTVSGAGFYYAPDPSSQIICSIGGNVAENSGGVHCLKYGVTTNHVLGVKIVTPEGAIVDLGSEIPESPGYDLTGVFVGSEGTLGIATEITLKILKTPESIRVLLADFMSVEAAGATVSDIISAGIIPGGMEMMDNMSINAVEDVVATGCYPRDATAILLVEVDGLEVEADLNSQRVAEICKKNGARNVTVATEADERLTIWKGRKAAFAAMGKMSPDYYVQDGVIPRTKLEYVLREIEALGQKFGYNVANVFHAGDGNLHPLILYNNAIPGALEQVEALGGEILKLCVKVGGSISGEHGIGADKRCYMPEMFSPADLETMQWVRLAFDPQGIANPTKLFPTPRTCGEAAQAHGQKVFEGIERF
>NZ_AP018203.1|WP_017287796.1|3167796_3168039_+|hypothetical-protein
MRAIEVTGSVNEEGCIQIDQPLPAAKSTRFRGILLFPDSESSLNQEWSSSAVQPSVQDWLDDPAEDIYTLEDGEPVSDEA
>NZ_AP018203.1|WP_017287798.1|3168563_3169454_+|alpha/beta-fold-hydrolase
MQVASSIDTVPGQYWNWRNEPVYYVKMGERNNRPPLLLIHGFGASTDHWRKNVIGLSQEFEVWAIDLLGFGRSAKPDWKYSGELWRDQIHEFVTEVIGAPAVVAGNSLGGYVGLCAASQRPESSAGLILINSAGPFTDIQGTTKPDPIRQVMGSFVMSLFHQDWASWLLFQYVRQKSTIRKTLEKVYLDQTAVTDRLIEEIQRPAFDQGADKVFASVFRTPQGEKVDVLLGQLTRPLLMLWGEADPWINARDRGAKFRSYHPQLTEHYLNAGHCPHDEIPDQVNALIRTWVTSAVN
>NZ_AP018203.1|WP_017287799.1|3169586_3170498_-|branched-chain-amino-acid-transaminase
MHNFLPIAYFKNQFLPFENANLSIATHALHYGTGAFGGLRGIPNPENPNQILLFRLDRHCQRLSNSARLLNFELPADKIQSIITDFVKKNQPKTSFYIRPFVYTSDLGIAPRLHNIEHDFFVYGLELGDYLSPDGVSCRISSWYRQEDRSLPLRGKISGAYITSSLAKTEAVSCGFDEAILLNSQGKVSEASGMNIFLVRNGELITPGYDQDILEGITRDSVLTIARDLGIKTIERPVDKSELFIADEVFLSGTAAKVTPVKRIETFEFSKHRPVTDKLREAVTAVTENRNETYRDWVNVIEI
>NZ_AP018203.1|WP_017287800.1|3170699_3172415_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MASHSRFQILLLSLLPLVHPSPALAQRVLPIPPPQDLPRPQPPQPSPPEPTPTPLPPPDQLLPGLTPPTPEPPENVSDTIQIKQIEIVGSTVFRPQDFAEITRKYVDRRISFAELLQIRTEITELYIKQGYVTSAAVLPPQVLTGGTVKIQIIEGAIASIDVIGTRRLNPAYIRSRIGLVAQKPLNVNRLLEGLRLLQLDPLIASISADLQAGTRSGTSVLQITIAESKTLTISPLLDNSRSPSVGSFRRQLEVSQANLLGLGDALRASYTNTNGSNGVDLSYIVPLNPRNGTLRLAYGSTRSRVIEEPFDILEIEARSRYYELTLRQPIVQRPTNELAIGLTFSRQESQTELGIDNIGPFPLSPGADEQGRTRVSALRFFQEYVQRSDRQVLAARSQFSLGLNFLNSTINEQAPDSRFFAWRGQAQWTRLLARDSLFLVRGDMQLADRTLVPLEQIGVGGQETVRGYRQDALLTDNGFLFSTELRLPIFRPRNGLVQLTPFVDLGTGWNRSGDNPEKNTLVGAGLGLLWRQGENFSARIDFGFPLVSIENEKRTLQENGIYFSIRYSPSF

Crispr_ID: NZ_AP018203_9

• CRISPR_ID: NZ_AP018203_9
• CRISPR_location: 3458662-3458746
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_AP018203_9

Consensus_repeat	Method
TCAAGTTAGCATTACTGAGGTTAGC	CRISPRCasFinder

spacers of NZ_AP018203_9

>9.1|3458687|35|NZ_AP018203|CRISPRCasFinder
GCCCGTAAAGGCAACTTCAACCAGGCAACTTTCTG

CRISPR arrays and Neighbor proteins around NZ_AP018203_9

CRISPR arrays

The CRISPR arrays of NZ_AP018203_9

>merge|NZ_AP018203|9|3458662-3458746|CRISPRCasFinder
TCAAGTTAGCATTACTGAGGTTAGCGCCCGTAAAGGCAACTTCAACCAGGCAACTTTCTGTCAAGTTAGCATTACTGAGATTAGC

>NZ_AP018203|9|9|3458662-3458746|CRISPRCasFinder
TCAAGTTAGCATTACTGAGGTTAGC	GCCCGTAAAGGCAACTTCAACCAGGCAACTTTCTG
TCAAGTTAGCATTACTGAGATTAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017288077.1|3462543_3462648_+|cytochrome-b6	unknown	unknown	gnl|CDD|285308
NZ_AP018203.1|WP_017288065.1|3450992_3451472_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl|CDD|376811
NZ_AP018203.1|WP_017288066.1|3451633_3453037_-|TldD/PmbA-family-protein	unknown	unknown	gnl|CDD|223389
NZ_AP018203.1|WP_017288078.1|3462677_3463055_-|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|197713
NZ_AP018203.1|WP_017288064.1|3448832_3450821_-|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|226701
NZ_AP018203.1|WP_017288062.1|3446535_3448062_-|anthranilate-synthase-component-I	unknown	unknown	gnl|CDD|223225
NZ_AP018203.1|WP_017288074.1|3460011_3460851_+|diaminopimelate-epimerase	unknown	unknown	gnl|CDD|234768
NZ_AP018203.1|WP_017288079.1|3463244_3464228_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|177093
NZ_AP018203.1|WP_017287779.1|3444254_3445502_+|IS110-family-transposase	unknown	unknown	gnl|CDD|376564
NZ_AP018203.1|WP_017288069.1|3455963_3458258_+|hypothetical-protein	unknown	unknown	gnl|CDD|223551
NZ_AP018203.1|WP_017288073.1|3459717_3459933_-|hypothetical-protein	unknown	unknown	gnl|CDD|212463
NZ_AP018203.1|WP_017288067.1|3453295_3453571_-|hypothetical-protein	unknown	unknown	gnl|CDD|375532
NZ_AP018203.1|WP_017288080.1|3464264_3465167_+|NAD(+)-kinase	unknown	unknown	gnl|CDD|179456
NZ_AP018203.1|WP_026148621.1|3460908_3461130_-|DUF4327-family-protein	unknown	unknown	gnl|CDD|372966
NZ_AP018203.1|WP_017288063.1|3448199_3448622_-|photosystem-I-reaction-center-subunit-II	unknown	unknown	gnl|CDD|367117
NZ_AP018203.1|WP_017288072.1|3459339_3459609_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288068.1|3454542_3455691_-|histidine-kinase	unknown	unknown	gnl|CDD|236462
NZ_AP018203.1|WP_017288061.1|3445728_3446094_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_051077796.1|3461441_3462461_-|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl|CDD|235066
NZ_AP018203.1|WP_017288071.1|3458884_3459343_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350221

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP018203.1|WP_017288078.1|3462677_3463055_-|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	2.1e-22	74.4	1.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017288077.1|3462543_3462648_+|cytochrome-b6	gnl|CDD|285308	pfam08041, PetM, PetM family of cytochrome b6f complex subunit 7. This family consists of the PetM family of cytochrome b6f complex subunit IV. The cytochrome b6f complex consists of 7 subunits and contains 2 beta hemes and 1 chlorophyll alpha per cytochrome f. It is highly active in transferring electrons from decylplastoquinol to oxidized plastocyanin.	4.42719e-06
NZ_AP018203.1|WP_017288065.1|3450992_3451472_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl|CDD|376811	pfam02542, YgbB, YgbB family. The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis).	4.30273e-95
NZ_AP018203.1|WP_017288066.1|3451633_3453037_-|TldD/PmbA-family-protein	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	1.99071e-132
NZ_AP018203.1|WP_017288078.1|3462677_3463055_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	1.46212e-19
NZ_AP018203.1|WP_017288074.1|3460011_3460851_+|diaminopimelate-epimerase	gnl|CDD|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	1.81464e-153
NZ_AP018203.1|WP_017288062.1|3446535_3448062_-|anthranilate-synthase-component-I	gnl|CDD|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	0
NZ_AP018203.1|WP_017288079.1|3463244_3464228_+|SDR-family-oxidoreductase	gnl|CDD|177093	CHL00194, ycf39, Ycf39; Provisional.	4.94351e-172
NZ_AP018203.1|WP_017287779.1|3444254_3445502_+|IS110-family-transposase	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.61414e-27
NZ_AP018203.1|WP_017288069.1|3455963_3458258_+|hypothetical-protein	gnl|CDD|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	2.21783e-89
NZ_AP018203.1|WP_017288073.1|3459717_3459933_-|hypothetical-protein	gnl|CDD|212463	cd01716, Hfq, bacterial Hfq-like. Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotropic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that modulate the stability or translation efficiency of RNA transcripts. Hfq binds preferentially to unstructured A/U-rich RNA sequences and is similar to the eukaryotic Sm proteins in both sequence and structure. Hfq forms a homo-hexameric ring similar to the heptameric ring of the Sm proteins.	8.24984e-13
NZ_AP018203.1|WP_017288067.1|3453295_3453571_-|hypothetical-protein	gnl|CDD|375532	pfam18068, Npun_R1517, Npun R1517. This domain belongs to NPun R1517 which is found in Nostoc punctiforme. Studies indicate that Npun R1517 is encoded by orphan gene 29. Npun R1517 adopts a sleigh-shaped structure with a two-stranded antiparallel beta-sheet forming the floor of the sleigh, a HTH forming the seat and a HTH forming the front of the sleigh.	7.88161e-27
NZ_AP018203.1|WP_017288080.1|3464264_3465167_+|NAD(+)-kinase	gnl|CDD|179456	PRK02649, ppnK, NAD(+) kinase.	0
NZ_AP018203.1|WP_051077796.1|3461441_3462461_-|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl|CDD|235066	PRK02746, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase PdxA.	0
NZ_AP018203.1|WP_017288063.1|3448199_3448622_-|photosystem-I-reaction-center-subunit-II	gnl|CDD|367117	pfam02531, PsaD, PsaD. This family consists of PsaD from plants and cyanobacteria. PsaD is an extrinsic polypeptide of photosystem I (PSI) and is required for native assembly of PSI reaction clusters and is implicated in the electrostatic binding of ferredoxin within the reaction centre. PsaD forms a dimer in solution which is bound by PsaE however PsaD is monomeric in its native complexed PSI environment.	7.43942e-94
NZ_AP018203.1|WP_026148621.1|3460908_3461130_-|DUF4327-family-protein	gnl|CDD|372966	pfam14217, DUF4327, Domain of unknown function (DUF4327). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	2.34047e-35
NZ_AP018203.1|WP_017288068.1|3454542_3455691_-|histidine-kinase	gnl|CDD|236462	PRK09303, PRK09303, histidine kinase.	0
NZ_AP018203.1|WP_017288064.1|3448832_3450821_-|GAF-domain-containing-protein	gnl|CDD|226701	COG4250, COG4250, Predicted sensor protein/domain [Signal transduction mechanisms].	2.78846e-67
NZ_AP018203.1|WP_017288071.1|3458884_3459343_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350221	cd09873, PIN_Pae0151-like, VapC-like PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Pyrobaculum aerophilum proteins, Pae0151 and Pae2754, and homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.56324e-32

Protein sequences

>NZ_AP018203.1|WP_017288069.1|3455963_3458258_+|hypothetical-protein
MQEDFRLIVDLVSVLAAAAAGGLFAALLKQPVLLGYLAAGVIVGPTGLGLIKEIIQVETLAQFGVAFLLFALGVEFSFSELKKVKVISLGGGGLQIALTILVTTLVSLAMGWVTSPPQGVFLGGILSLSSTAVVLKCLMERNETSTPHGQVMLGILVVQDLALGLMLAVLPALDQPAEEVGLAIGWALLQTGLFALGAVAAGIWVIPRLLRLLAKTESRELFLLGVVALCLGIALLTEHLGLSIEMGAFVAGLMISDAEYADQTLTYVEPLRDIFASLFFASIGMLIDPVFLWNNLELILGLVTLVFIGKFLIVTPLVRIFRYPLKTALIAGLGLAQIGEFSFVLASEGQTLGLVSRRVYLLILGTTAVTLVVTPFVLRLVPKLFAWGESIPWLAKFLEQSDEPLAISEDLPIKDHFIVCGYGRIGRNIVRLLRDRNHPVLVIDQSESQIQKVRDAGIPYIYGNAASSYVLEKAGVAEAKGMAIALPDPMSTRLCVKRSLEISPDLDLVVRANKDKDIELLYQLGAREVVQPEFETSLELSAHLLAGIGIPSPAVQREVQMIRNSHYLEFRPDQASEEISRDLKAVTGEMNSRWYALPEESPLLGMSIEETDIRRLTGVSVMAIRRAGGLTIDYPESLTTLEQGDRLLIVGETDEVAAFDQLARGEAAVPSTNSSCQWLQVPSESPLIGKTLLELELQQRYKITIQTIRRDGKLIRFPEPDAEIQNGDRLLLCGGFHALTQAQEALSPKTEVPLITTSIAEAES
>NZ_AP018203.1|WP_017288068.1|3454542_3455691_-|histidine-kinase
MTMQAHSNPATDPKVTLQILLFVDQRPASREQIRQIRGFLKDRSAECPFELEVVDVGEQPYLAEHFRLIATPALIKLHPEPRQTLTGSDLIVQLKNWWSRWQKSIEETLPSDSTEPSASVGYSAELIKLTDEVFRLQRENENLQAQLQFKDQIISMLAHDLRNPLTAASIAIETLEIAYKQADGQTSRLTPQMTANLLKHGRTQIRTIDRMITDILQAARGTSSELHIQPEKIDLRALCEDVLAGLGDRMQSKNQQIATDMPSDLPIVYADGERIRQVLVNILDNAIKYTPTGGKIQVSILHRTAQKVQVSICDTGPGVPPENRDRVFEDHYRLQRDEAQDGYGIGLSLCQRIVRAHYGQIWVDSIANQGSCFHFTLPIFRS
>NZ_AP018203.1|WP_017288067.1|3453295_3453571_-|hypothetical-protein
MNYDPLECKVTAPAEVGVYECEVRLKFRLIEEKGALSNPEQLLEFLLDAYSCGADEYLEPLDVDVKATEISELAASPQMRRRLMRLRNSKD
>NZ_AP018203.1|WP_017288066.1|3451633_3453037_-|TldD/PmbA-family-protein
MNSALSDAKNLISDLMSRYRHQVDYLAIRLEAAEGTDILLRGHKIETLSEGISIGGQVRACYKGGWGFSSFNQLSSLKERVEDALAAAKLVGMDETILAPVAPIQDDRALRLTGSDPRQISLAQKKSLCQHYGEILRSVDPRIATISVRYGDSAQKIILATSDGSMIEQSWVDLEMRFAATARDGETVQTGRETVGSRKAYEDLLGLDRQVEEAAQRAVNSLALPPVKGGAYTVVIDPILSGLFVHEAFGHLSEADMAYENPDILEVMSLGRRFGSPELQIYDGAAIEGHRGSYFYDDEGVPATTTQLIKDGVLVGRLHSRETAGKLEEAPTGNARCLNYHYPPIVRMTNTWIERGKTPVKDLFQNIQEGVYARNWIGGMTNGEMFTFTAGEAWMIRNGEVAEPVRDVTLSGNAFKTLADIEAIGDDFFWDESGGCGKGGQSGLAVGCGGPSLRIRDVVVGGEAIDD
>NZ_AP018203.1|WP_017288065.1|3450992_3451472_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MKLRIGNGYDIHRLVSGRDLILGGIQIAHETGLLGHSDADVLTHAIMDAMLGALSLGDIGHYFPPTDPKWAGADSIVLLEQVHRLIQDQGWQISNIDSVIVAERPKLKPHIEAMRSRLANALNLAPDQVGVKATTNEKMDAVGNEQAIASHAVVLLIQA
>NZ_AP018203.1|WP_017288064.1|3448832_3450821_-|GAF-domain-containing-protein
MILTDSVLEALLNALPQVRPQIYFKSSLTALSHAMEDQVLAGHDRPLVIASFQRERFYRQEAHRYLRIASRTDQVYVLAAPETDFTNRSEHYETIAFEPEDGLSQEWHLVVMSEQYASCLICRERDLTTENQSAPPLHVDQSRRFEGIWTFDRDIVLKAAEILLHRILQYRPELQTKIAPVLDQMATGMVSKLNQVDPAPFADRLVTYLQAGQYKLAKAYRSIAEKERKERLVNSITSAVRRSLNPTEILNVAAEELGKVLGAERCLIYRCKSTDLSATLSHEYLTESMPSLVGHVWTLQGNPLFEEVAQRQEAVFIEDTQTDPRFSMIKDGDRTLQALTLDWNIRSWLMVPVLHQNQVLGMVELHYWGATPHVLERDEVEMVEAIATQIGVALIQAESFANLEDLNQQLEALDRTRSNLIAITGHELRTPLSTIQVCLESLASEPDMSPDLRQVMLNSALVDGERMRKLIQDFLTLSRLESGRVEWRFEPLPLWECVDLALSSLQTRRMTTNLPQIVTQLSTELPLVQVDGEWLVEVLTKLLDNACKFTDATGRVTIRAQRSGDTMLEVMISDTGRGIEENRLETVFDRFYQEEGALRRTTGGTGLGLAICRQIITNWGGKIWAESSGKDLGSEFHFTIPIVATGETKRTAQRKRTSRSRD
>NZ_AP018203.1|WP_017288063.1|3448199_3448622_-|photosystem-I-reaction-center-subunit-II
MSETLTGQAPLFGGSTGGLLTKALVEEKYAITWSSPKEQVFEMPMCGAAKMRQGDNLLYLARKEHCLALGGQLRTKFKITNYKIYRVFPNGEIQYLHPADGVFPEKVNEGRVAVNSVPRNIGSNPEPAKLKFSGRLPYDP
>NZ_AP018203.1|WP_017288062.1|3446535_3448062_-|anthranilate-synthase-component-I
MISPDFSQFAELAKQGNFVPVYQEWVADLDTPVSAWYRVCAGQPYSFLLESVEGGETIGRYSFLGCDPLWILEAKGDRTTQTHRDGTQQVFEGDPFTTLSECLAPYHPVKVPELPPGIGGLFGFWGYELINWIEPRVPIYQATEDDLPDGLWMQIDQVLIFDQVKRKIWAIAYADLRDPNTDLKAAYQQACDRVSQLVDKLKAPFSEEDRLLSWTPKNDTSVNWTSNTTKEQYCASVETAKNYIKAGDIFQVVISQRLSSEFEGDPFALYRSLRLINPSPYMAYFNFGDWQIIGSSPEVLVKAEQASDPTEPRIATVRPIAGTRKRGKTHAEDVALEQDLLADPKEVAEHVMLVDLGRNDLGRVCINGTVKVDELMVIERYSHVMHIVSNVIGQLSPDKSAWDLLKAGFPAGTVSGAPKIRAMEIIHELEPCRRGVYSGAYGYYDFEGQLNSAIAIRTMVVREQGNGKHTVSVQAGAGLVADSVPESEYQETLNKARGLLEAIRCLQS
>NZ_AP018203.1|WP_017288061.1|3445728_3446094_-|hypothetical-protein
MSITQKEVVEYLLDLTLRHKLVEQAMASCDCWFTNNGGEIDGWIPQDLEKQFFSHTLVFQRSDWDLIYVDTRLKLLASNGREIGHYRLISTLDGQIDDDYLVLELSKDDWENDRVVTVCII
>NZ_AP018203.1|WP_017287779.1|3444254_3445502_+|IS110-family-transposase
MPYVALIGLDWADQKHDVCLYDCAAQTQEHCVIGARPEAIEAWAMQLRVRYGGQPIAVCLEQKRGPLIYALCKYEFLVLYPVNPQTVSKYRQVFTPSRAKDDPTDAALQVELLRKHRDKLTVWQPASPMLRKLQALVEWRRTLIEDIGRTTNRLVDVLKGYFPQAIDCFEHRDTMVFCDFLTQWSTLSAVQQVSDEQLQQFFCEHHSRYKDCNARRIECLRNGIPLTQDSAIVESSQLMVQALVSQLRSLLTSVRQFEAQIDREFNQLPDAAIFAALPHAGTNLAPRLLLAFGEDRTRYQTAQDLLQYAGIAPVTERSGKKCWIHWRWGAPRFLRQTFIEWANESRKASLWAKAFYQAQKQAGKTHQAAIRALAFKWIRILFRCWQDRVPYDEAKYLLALHQKGSPLAQQILSQA
>NZ_AP018203.1|WP_017288071.1|3458884_3459343_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MTVSLRCVIDTNVCIKQFIADPLTPKVNQLFDHLSNPLTEFFISDLFYIECANVLWKYVRANLYTATQVKADLASLKALRLQVASTQNLMEEAVEIGLNYGISAYDGSYVALSRLVSAPFLTLDNRLVNSLSSSGFDVRLFTNFPIPALPDL
>NZ_AP018203.1|WP_017288072.1|3459339_3459609_-|hypothetical-protein
MATFQIENLPDELYSQIQDLAAENNVTLNEAVIHLLEQACQTNETEKDRAHYAKSMSEILQEIRSRPRVNPSDFGLPDSTVLIQEDRNR
>NZ_AP018203.1|WP_017288073.1|3459717_3459933_-|hypothetical-protein
MSIELDTGLPSTRQIQTIIREEKEVEMKLSTGDLLTGKVRWQDPHCICIMDHYDQPTIVWRQSIVFVKPKM
>NZ_AP018203.1|WP_017288074.1|3460011_3460851_+|diaminopimelate-epimerase
MAIEFTKYHGLGNDFILIDNRASTEPKLTPDQAIAWCDRHFGIGADGVIFALPGQDGTDYTMRIFNSDGSEPEMCGNGIRCMARFLADLETAETGKFQEKYRIQTLAGIITPKFESNGQITVDMGEPRLLASEIPTTLTGEKVIDQPLEVAGKSWNVTCVSMGNPHCITFVDDVAAIELEKIGPLFEHHPVFPQRTNTEFIEVVRSDYLKMRVWERGAGITLACGTGACASLVAGVLNEKCDRRATIELPGGCLDIEWAADGRIYMTGDAEKVFSGSRS
>NZ_AP018203.1|WP_026148621.1|3460908_3461130_-|DUF4327-family-protein
MLQTAQYSLCMIQDEVRQLIDRGVVSRHQPIYTLCKHIPAREWVRFETELERFDFLLRDRIGDLMAQECWDND
>NZ_AP018203.1|WP_051077796.1|3461441_3462461_-|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MPRLVISMGDPAGIGTEVILKALADPAISQQAEITIAGNRNILLETYDRLDSAANPENLNLLHIETPGSITLGTGNAASGEAGFRYLETAIDRTLSGEFDVIVTAPIAKSAWKAAGHIYPGQTELLAEKAGVNRFGMMFVARSPHTDWELRALLATTHIPLSQVPEKLTPEVLTLKLDLLIESLQDSFGITQPRIAIAGLNPHSGEQGQLGREEIDWISDWLEAMRDRFPQAQLDGLSPPDTMWVKPGQAWFGLGQVNAHDGYLALYHDQGLIPVKLMAFDRAVNTSIGLPFIRTSPDHGTAFDIAGKGIADATSMKAAIEFAIRLAKRKALSQSMKGI
>NZ_AP018203.1|WP_017288077.1|3462543_3462648_+|cytochrome-b6
MAGEIFNTAFLASTLILVGLSLGFLLLKLQGGEE
>NZ_AP018203.1|WP_017288078.1|3462677_3463055_-|helix-turn-helix-transcriptional-regulator
MANPNPAETEQCAVQHPVNLNNIRFLHRDLLSVEKSQRMAEFFSLLGDANRLRILSALAVQELCVCDLAAAVKMSESAVSHQLRALRSMRLVGYRKQGRNVFYSLKDHHVLNLYREVAEHLDEEE
>NZ_AP018203.1|WP_017288079.1|3463244_3464228_+|SDR-family-oxidoreductase
MSVLIVGATGTLGRQITRRALDEGYKVRCLVRSPRKAAFLKEWGAELVTGNLCYPETLPAALEGVTAIIDAATARATDSLSIKEVDWTGKVNLIQAAKKAGIERYIFFSILDAEKFPKVPLMEIKTCLEKFLAESGLSYTILRPCGFLQGLIGQYAIPILEGQSVWVMGNTAPTAYMDTIDIAKFAVQALKVPESIGKTLPVVGSKAWSADEIIKVCERLSGKQAKVTKTPIAVVRISRRIAQFFQWTWNIADRLAFTEVVATGRPLTASMDETYEVLGLDPQEMTTLESYLQEYFSRILKKLKEVEYAQEQAKKKKERTKKAYPRF
>NZ_AP018203.1|WP_017288080.1|3464264_3465167_+|NAD(+)-kinase
MPKAGIIYNDDKPIACQVATDLEAKLTSLGWDVALATGAGGILGYASPESPICHTPIDRLVPPGFDSEMKFAIVLGGDGTVLSAFRQVAPCNIPLLAVNTGHLGFLTEILLNQLPAALDALLSEDYEIEERTMLHVQIIREEAMLWEALCLNEMVLHREPLTSMCHFEISVGRHNRVDIGADGIIVSTPTGSTAYALSAGGPVIVPGIPVMILVPICPHSLASRSLVFPNRDPVTIYPAIPHRLVLTADGNAGSYVLPDDHVCVKKAPYPARFVRLRPPEFFSVLREKLGWGVAHVAKPT

Crispr_ID: NZ_AP018203_10

• CRISPR_ID: NZ_AP018203_10
• CRISPR_location: 3494815-3495039
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP018203_10

Consensus_repeat	Method
TGCACGAGTTGCGATTCCCCAAATCATTCCGTTGTTGAAAGA	PILER-CR

spacers of NZ_AP018203_10

>10.1|3494861|57|NZ_AP018203|PILER-CR
GTCCAATGTCTTTCCTCGTTCTGCGGCAGTAAATGCTTTAGGAAAGATGGGAGAGTC
>10.2|3494964|48|NZ_AP018203|PILER-CR
AATGATTCGGGAGGATGCTGCTCTTGCTCTAGGAAAGATAGGAGAGCT

CRISPR arrays and Neighbor proteins around NZ_AP018203_10

CRISPR arrays

The CRISPR arrays of NZ_AP018203_10

>merge|NZ_AP018203|10|3494815-3495039|PILER-CR
TGCAATTCCTCATCTCATTCCGCTGTTGAAAGAGTCCAATGTCTTTCCTCGTTCTGCGGCAGTAAATGCTTTAGGAAAGATGGGAGAGTCTGCACGAGTTGCGATTCCCCAAATCATTCCGTTGTTGAAAGACAAAATGATTCGGGAGGATGCTGCTCTTGCTCTAGGAAAGATAGGAGAGCTTGCACGAGTTGCGATTCCCCAAATCATTCCGTTATTGAAAGA

>NZ_AP018203|10|2|3494815-3495039|PILER-CR
TGCAATTCCTCATCTCATTCCGCTGTTGAAAGAGTCCAATGTCTTT	CCTCGTTCTGCGGCAGTAAATGCTTTAGGAAAGATGGGAGAGTCTGCACGAGTTGCG
ATTCCCCAAATCATTCCGTTGTTGAAAGACAAAATGATTCGGGAGG	ATGCTGCTCTTGCTCTAGGAAAGATAGGAGAGCTTGCACGAGTTGCGA
TTCCCCAAATCATTCCGTTATTGAAAGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_081614795.1|3489345_3490104_+|hypothetical-protein	unknown	unknown	gnl|CDD|236892
NZ_AP018203.1|WP_017288126.1|3506001_3506445_+|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl|CDD|235443
NZ_AP018203.1|WP_017288108.1|3487880_3488150_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288113.1|3491993_3492764_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288120.1|3499213_3500569_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl|CDD|184646
NZ_AP018203.1|WP_017288121.1|3500708_3501575_+|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl|CDD|371375
NZ_AP018203.1|WP_017288106.1|3486656_3487526_+|DUF72-domain-containing-protein	unknown	unknown	gnl|CDD|376655
NZ_AP018203.1|WP_017288111.1|3490183_3491044_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133005
NZ_AP018203.1|WP_017288124.1|3504425_3505673_+|competence/damage-inducible-protein-A	unknown	unknown	gnl|CDD|234789
NZ_AP018203.1|WP_017288117.1|3495198_3497037_-|biosynthetic-type-acetolactate-synthase-large-subunit	unknown	unknown	gnl|CDD|236014
NZ_AP018203.1|WP_017288115.1|3493930_3494473_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288109.1|3488175_3488958_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288112.1|3491256_3491964_+|DUF502-domain-containing-protein	unknown	unknown	gnl|CDD|225480
NZ_AP018203.1|WP_017288114.1|3492767_3493655_-|hypothetical-protein	unknown	unknown	gnl|CDD|226983
NZ_AP018203.1|WP_017288127.1|3506460_3506847_+|hypothetical-protein	unknown	unknown	gnl|CDD|236177
NZ_AP018203.1|WP_086371064.1|3498024_3499119_+|ferrochelatase	unknown	unknown	gnl|CDD|223353
NZ_AP018203.1|WP_017288123.1|3503388_3504429_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl|CDD|133463
NZ_AP018203.1|WP_017288107.1|3487551_3487812_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288118.1|3497320_3497836_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288122.1|3501683_3503054_+|serine-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234571

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_081614795.1|3489345_3490104_+|hypothetical-protein	gnl|CDD|236892	PRK11281, PRK11281, mechanosensitive channel MscK.	7.17796e-06
NZ_AP018203.1|WP_017288120.1|3499213_3500569_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl|CDD|184646	PRK14360, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_AP018203.1|WP_017288124.1|3504425_3505673_+|competence/damage-inducible-protein-A	gnl|CDD|234789	PRK00549, PRK00549, competence damage-inducible protein A; Provisional.	0
NZ_AP018203.1|WP_017288106.1|3486656_3487526_+|DUF72-domain-containing-protein	gnl|CDD|376655	pfam01904, DUF72, Protein of unknown function DUF72. The function of this family is unknown.	1.1071e-74
NZ_AP018203.1|WP_017288111.1|3490183_3491044_+|glycosyltransferase-family-2-protein	gnl|CDD|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	5.92055e-73
NZ_AP018203.1|WP_017288126.1|3506001_3506445_+|type-II-3-dehydroquinate-dehydratase	gnl|CDD|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	7.36059e-94
NZ_AP018203.1|WP_017288117.1|3495198_3497037_-|biosynthetic-type-acetolactate-synthase-large-subunit	gnl|CDD|236014	PRK07418, PRK07418, acetolactate synthase large subunit.	0
NZ_AP018203.1|WP_086371064.1|3498024_3499119_+|ferrochelatase	gnl|CDD|223353	COG0276, HemH, Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism].	3.16917e-77
NZ_AP018203.1|WP_017288122.1|3501683_3503054_+|serine-hydroxymethyltransferase	gnl|CDD|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NZ_AP018203.1|WP_017288112.1|3491256_3491964_+|DUF502-domain-containing-protein	gnl|CDD|225480	COG2928, COG2928, Uncharacterized conserved protein [Function unknown].	3.33755e-76
NZ_AP018203.1|WP_017288114.1|3492767_3493655_-|hypothetical-protein	gnl|CDD|226983	COG4636, Uma2, Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only].	3.03273e-13
NZ_AP018203.1|WP_017288127.1|3506460_3506847_+|hypothetical-protein	gnl|CDD|236177	PRK08186, PRK08186, allophanate hydrolase; Provisional.	3.42183e-34
NZ_AP018203.1|WP_017288123.1|3503388_3504429_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl|CDD|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.29393e-89
NZ_AP018203.1|WP_017288121.1|3500708_3501575_+|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl|CDD|371375	pfam11103, DUF2887, Protein of unknown function (DUF2887). This bacterial family of proteins has no known function. These proteins may be distantly related to the PD(D/E)XK superfamily.	7.65006e-96

Protein sequences

>NZ_AP018203.1|WP_017288115.1|3493930_3494473_+|hypothetical-protein
MGSVFLALAIGTTLTVSEGASAQSTPPAGQQIQYTGSFTNATHNLSGEVLINLSFGSDDQVSGYINFTNYPNARALCGAGKLTGRRQGKTLQFRFVSDDPDPGCGFDRGWIFTGSATLSSDRSAIENGTYQVILRGRRVESTGIFRATAQNVDPVATRMRQLSLREQVGYLTQLIKTGSE
>NZ_AP018203.1|WP_017288114.1|3492767_3493655_-|hypothetical-protein
MTSPFPQPDPPLPPWQTLPTMYDLPSENPEEPGLPDEFHDLQPQLLSRTLRLSQSVTDQFFTGAELNLYYDSAHPQWYKRPDWFLSIGVPRLYQGRDLRNSYVIWQERRAPFVVVELLSPGTEKEDLGSYADTPEIELEPLQPVREASETPTAKGQKSEKPPSKWKVYEQILRVPYYIVFSRYDDQVHFFKLVGGKYQAQPLDPENSRIWIPELEIGLGLWQGEFEGICRSWLRWYDDQGNWILTDAEQERQRANQAESQLLQVARNLLQTGMSIEQVSQITGLTETEVQQLQTE
>NZ_AP018203.1|WP_017288113.1|3491993_3492764_+|hypothetical-protein
MPGSPSVLALDFDGVICDGLKEYFQTSWQAYAQIWQTDTTPNEQIAPAFYRLRPVIETGWEMPILIRSLVVGVQEEEILQNWLTIATQTIEKEQLKPLEISAAVDGIRDRKIATDLDNWLAEHEFYPGVIDRLNTILNSSTDFFIISTKEGRFIKQLLKQEGIELADSQVYGKESKRPKPQVLKELQQVYQGAIWFVEDRLKTLQAVEQQESLQEVELFLADWGYNTRSEREEAQNSDRVHLISLQQFGQDFPNWL
>NZ_AP018203.1|WP_017288112.1|3491256_3491964_+|DUF502-domain-containing-protein
MKEISVIHRLKQDLKNDLIAGLLVVIPLATTIWLTYTIANWVINFLTRVPKQLNPFDGLHPLLVNLLNFIVGLAVPLFSILFIGLMARNIAGRWLLDVGEQVLQAIPLAGAIYKTLKQLLETVLRDSSGKFRRVVLVEYPREGVWSLGFVTGAIGAEVQSHFKTDMLSVFIPTTPNPTTGWYAVVPENSVINLSLPIEDAFKVIISGGIVSPDSMNVITTSTTTKPPLVEATADE
>NZ_AP018203.1|WP_017288111.1|3490183_3491044_+|glycosyltransferase-family-2-protein
MFSIFILTHNEEVEIAACIESALLSDDVIVVDSCSDDQTIAIANSYPVRVIQHPFESHGKQRTWMLQSVPVKHEWVYILEADERMTPELFQECLDTIQTAEHIGYYVAERVMFMGKWIRRSTQYPRYQLRLFQKEKVWFTDYGHTEREVVDGTTGFLKETYPHYTSGKGFSRWIDKHNRYSTNEAIETIHQLETGGLNWSALFFGKSEVERRRALKDLSLRLPFRPLIRFFYMYLLLGGMFDGYPGFTWCMLQAFYEYLITLKVWELQHQPVDSPKLVTPILENVK
>NZ_AP018203.1|WP_081614795.1|3489345_3490104_+|hypothetical-protein
MIVSSMVDYISVLIPPNFSDKAWFANVVTQIVDRGIIPLVGFAFLFAGAFLESGSFNLGERVKPVMSFRFWAMLLSLLLGLVFLIAFPLHLNNTRQVSDQALERIDREAKDAENQLNTQVQQRQDQITAALRDPNQSKQLDDQLKQIDAAIASGQLKGDQLTQAQRAQKELQALKANPNSVADRAKEFRNTQLTSIRERRTQAENQARNEFWKTGIRVGISSLLLSLAYFVIGWSGLRELGVIGGKRKPVMR
>NZ_AP018203.1|WP_017288109.1|3488175_3488958_-|hypothetical-protein
MATLSVISQKLNIYTPQNITVRQGDLIVPLLDGQLLRVTPQGESSAIANFMKDELGVPFGMTAQGNDVIATVSGFLPQHYLMRVKPDGKVETIADLSRQSGAYGAPFGVTVFRDEYWVTVSTDVIESTSELVRVSQKGEVKAIANLTEFKNPFGLVVQGDSVVVAQSSGHLVRVSEKGDVKAIVNLQEAGFGLPFNVAIWRDQIVATTNAGLVVAVDQAGKVSTIADVKTAKYQIPSGIVVFEKDLIVTTNGGFLLRISV
>NZ_AP018203.1|WP_017288108.1|3487880_3488150_-|hypothetical-protein
MTDPSEIESGIEIESEQAPTLSTGSVRKQLRIWIAASIWFATVIGYKSQFPTLNPFIDILVIAFTSSILAIFVGASVGDILKRVLQNWY
>NZ_AP018203.1|WP_017288107.1|3487551_3487812_-|hypothetical-protein
MLQTFKAVLKGNSIEWLDEAPELGEQSIPVHITVLEETTGLDAATRGQKMAEVLERLSANRAFSGIDPIAWQHEIREDCSIPGRDE
>NZ_AP018203.1|WP_017288106.1|3486656_3487526_+|DUF72-domain-containing-protein
MIESSFSDRTKFRMGCAIWAYKQWVGDLFPPKSKASDFLNLYSRRFACVEGNTTFYSIPDRATVGRWKSETPLGFKFCPKLPKTLTHSGKLASSISGALKFLELMQGLDDRLGVLFAQLPPSYSPANFADLETFLRGWKGADLALEVRHARWFQEPHRSRLNELLQELKIGRVLLDTRPIYECEDDPQLESERKKPKVPLQPDVTAPFTLIRYISHPTLNQQYLEEWVKIVDRWLQQGTEIYFFVHCPVEEHSPQNARQFQRLLEQQDVNVPPLPWDLIEQPPSQMSLF
>NZ_AP018203.1|WP_017288117.1|3495198_3497037_-|biosynthetic-type-acetolactate-synthase-large-subunit
MQLQQRSAVQRVTGAFALIDSLSRHGVKHIFGYPGGAILPIYDELYRAEKAGILQHILVRHEQGAAHAADGYARATGQVGVCFATSGPGATNLVTGIATAHMDSIPMVIVTGQVPRPAIGSDAFQETDIYGITLPIVKHSYVVRDPRDMARIVAEAFFIASTGRPGPVLIDVPKDVGVEQFEYEPIDPGSVRLTGYRPTTKGNPRQIGQALKLIRQAQKPLLYVGGGAIAAGAHAEVKELAERFKLPVTTTLMGIGAFDEHHPLSVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFASRAKVIHIDIDPAEVGKVRLPDVPIVGDVKQVLTDLLERSADENDPANPNQTEAWLARIDRWREDYPLVVPEYPGVLSPQEVIAEVGRQAPHAFYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGMPAAMGAKVAVPDEEVICISGDASIQMNIQELGTLAQYGINVKTVIVNNGWQGMVRQWQEAFYDERYSNSNMQVGTPDFVKLAEAFGIKGMIVETREELKSAIAEMIAHPGPVLMDVRVKKNENCYPMVPSGKSNAQMIGLPERKLLERAAETVQCASCGTENLPTNKFCPNCGAKI
>NZ_AP018203.1|WP_017288118.1|3497320_3497836_-|hypothetical-protein
MQIFICPGIHSPTLTTQFVTALGLSQQEVLIFPADQPVYSPQHVLDFFEPQAPVVMIAFSAGVVGAIAATRTWYDRNIPISALIAIDGWGVPLFGDFPIYRVSHDQFTHWSSKLLGGGESFYADPAVDHLTMWHSPHLVRGYVDFSNRTPNRVTTAATFILEKAGITQFQS
>NZ_AP018203.1|WP_086371064.1|3498024_3499119_+|ferrochelatase
MGYGEVESYEDFANYNEQALNLLTAKFAPVPTWVYPPLAKLLAVFDLHEWGHQHGNFISPHNAIFERQRAGVEEILQEKWGDRIQVFKAFNFCKPFLPEQVLAEIKAQGFSKILIYPLLVVDSIFTSGIAVEQVNKALANSADEGEHWLKGTRYIPSFFDRPEYLNLMARMVEKQIQSDLAERYLPSQIGIVLMNHGCPHKAKGFTSGITESQALYDKVRDRLIDKYPLISVGWLNHQTPLIEWTQPNADLAAKNLIELGAKAIVFMPIGFATENHETLLDVEHIIEKLHRKYSDVKYVRMPCVNDDADFLKMVADWANPQIDSLLTEEALAVTPVHGEVHHHHHHGHDHDHDHAHDHEHAHHH
>NZ_AP018203.1|WP_017288120.1|3499213_3500569_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MVAVAILAAGRGTRMKSDLPKVLHQLGSRSLVERVLGSTTAIAPSRRLVIVGYQADSVREALADYPDEIEFVDQTEQLGTGHAIQQLIPSLENFDDDLIVLNGDLPLLRPETLSLLLETHRAKGNPATLLAAHVPDPTGYGRVFCDENQILTEIVEDRDCTPEQRLNDRMNAGAYCFRWKDLVQVLPKLNSNNEQKEYYITDAINFFDAVTVVDVPDYQEVLGINDRAQLADAYAILQKRIRDRWMREGVTIIDPNSVTIDDTVELEANVTIEPQTHLRGKTTIKTGSRIGPGSLIEDSQIGENVTVLFSVVAGSVIHDNAQIGPYSHLRAPVEIGQGCRVGNFVELKNTKLGEKTNAAHLSYLGNATIGNRVNIGAGTITVNYDGVKKYPTTIGDRTKIGSNNCLVAPITIGEDVTTAAGSTITEDLPNDCLAIARARQVVKPGWKRKDQ
>NZ_AP018203.1|WP_017288121.1|3500708_3501575_+|Rpn-family-recombination-promoting-nuclease/putative-transposase
MRRDSIFYALFRQSPSLLFELLDSPPLNAEAYRFDSVAVKEPKFEIDGVFLPPDSEAAGIVYFCEVQFQKDELLYERLFSESSFYFYRNRTKFSDWRGVVIYPSRSTEQSDTLPFEDLLGGHRICRIYLSELGEIEQLPLGIALMVLTTIAENRSFESARGLLDRVQQSEFSTQKRRDIIEMVTTILVYKFTDLGRQEIEQMLGTSLQQTRVYQEAKEEGREEGREEGREYECRSLVLLQLNQKLGSLSEETIAQISTLTLDQLESLAIALLNFTTMRDLTAWLEQIC
>NZ_AP018203.1|WP_017288122.1|3501683_3503054_+|serine-hydroxymethyltransferase
MFYPLIRVSFHCSIARLEGRLPNRRIKGISTVTQSDFLAKSDPALAEMLQQELQRQRDHLELIASENFTSPAVMEAQGSVLTNKYAEGLPNKRYYGGCEFVDRVEQLAIDRAKELFGAAHANVQPHSGAQANFAVFLTLLKPGDTIMGMDLSHGGHLTHGSPVNVSGKWFNVQHYGVSQATEQLDYDQIRDLALQHRPKLLICGYSAYPRVIDFEKFRAIADEIGAYLLADIAHIAGLVATGHHPNPIPFCDVVTTTTHKTLRGPRGGLIMTRDAELGKQLDKAVFPGTQGGPLEHVIAGKAAAFGEALKPEFKTYSGQVIENAAAMASQLQNRGFKIVSDGTDNHLMLVDLRSIKMTGKIADQLVSGVNITANKNTVPFDPESPFVTSGLRLGSPAMTTRGMGTAEFTEIANIIADRLLSPEDDTVAQDCRRRVAALCERFPLYPHLAAQVPALV
>NZ_AP018203.1|WP_017288123.1|3503388_3504429_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MPSFFAAFLISFLVVIVTTPIINRYGRRIGLVDQPNHRKVHQRPMVRLGGVAMFIGVVMAMLVAWGMGGFDFLRPGKESEVLGVAIGGIAFFLIGLADDLFNLSPKTRLILQVVVSGLVWQSGVQIDFLTNPLAGLGLSALPEWASLAITVVWLVGMANAINWIDGLDGLAAGVSGIAAFVMFWTCLFMGQPHAALFAAALAGAAFGFLRYNFNPAQIFMGDGGAYFIGFTLAAVSVIGLVKSVTTVAVLLPYVILAVPILDMSAVILDRLRRGKSPFVADKRHLHHRLLKAGLSQRLAVLFIYSLTLWAGSLAMAVSGMPSGVGYAIAATVILSVTSWQVWRTAR
>NZ_AP018203.1|WP_017288124.1|3504425_3505673_+|competence/damage-inducible-protein-A
MNAEIISVGTEILLGDILNSNAQFLAQQFAELGIPHYFQTVVGDNPERLKRAIAIASDRANLIVFTGGLGPTPDDLTTETIADFFQTPLVEKPEIIEDIQQKFAQRGRMMTDNNRKQALIPEGANILCNAIGSAPGMIWQPRANLTILTFPGVPTEMKYMWREVAVPYLKSQGWGKDIIVSRTLRFWGISESALAEKVAPFFDLQNPTVAPYANYGEVKLRISAKAASAEAAQALITPIEQQLSEIAGIDQYGADQDTLASVVGDLLKSRHETLSVAESCTGGGLGQMLTRVSGSSAYFWGGIISYDNSVKEKMLGVDPSAIAEQGAVSAIVAEQMAMGVRTQLNTTWGVSITGVAGPEGGTDAKPVGLVYIGLANAEGATSQPYRFGDRGREWVRQVSACSALDQLRRRLLNKS
>NZ_AP018203.1|WP_017288126.1|3506001_3506445_+|type-II-3-dehydroquinate-dehydratase
MDSILVLHGPNLNLLGKREPGVYGVATLDEINQALEKEAQSLGFEIATAQSNHEGALVDLIHDAMGRHAGILINPGAYTHTSVAIRDAIAGVNLPAVEVHLSNIHKREEFRHHSYIAPVAIGQICGFGAESYRLGLQALVHYLRQNM
>NZ_AP018203.1|WP_017288127.1|3506460_3506847_+|hypothetical-protein
MNSAVRLAVNGTLMRGLELNQNLLAIEAKFLRETQTEPAYRIWSIGDRHPAMLKVKEKGVAVAVEVWEVPASGLGTLLMQEPPGLSIGKVRLIDGEEVLGVLGEPFLCEGQVEITEYGGWRAYTEAKK

Crispr_ID: NZ_AP018203_11

• CRISPR_ID: NZ_AP018203_11
• CRISPR_location: 4238444-4238689
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_AP018203_11

Consensus_repeat	Method
TTTGGTGTCGCTNNTGGT	CRT

spacers of NZ_AP018203_11

>11.1|4238462|42|NZ_AP018203|CRT
GTCGTATTTGGTGTCGCTTTTGGTATCATGGTTGGTGTCGCA
>11.2|4238522|18|NZ_AP018203|CRT
GTCGCGTTTGGTGTCGCG
>11.3|4238558|30|NZ_AP018203|CRT
ATCGTGGTTGGTGTCGCTAGTGGTATCGTG
>11.4|4238606|18|NZ_AP018203|CRT
ATCGTGGTTGGTGTCACG
>11.5|4238642|30|NZ_AP018203|CRT
GTCACGTTCGGTGTCGCTAGTGGTGTCACG

CRISPR arrays and Neighbor proteins around NZ_AP018203_11

CRISPR arrays

The CRISPR arrays of NZ_AP018203_11

>merge|NZ_AP018203|11|4238444-4238689|CRT
TTTGGTGTCGCTTTTGGTGTCGTATTTGGTGTCGCTTTTGGTATCATGGTTGGTGTCGCATTTGGTGTCGCGTTTGGTGTCGCGTTTGGTGTCGCGTTTGGTGTCGCTAGTGGTATCGTGGTTGGTGTCGCTAGTGGTATCGTGGTTGGTGTCGCTAGTGGTATCGTGGTTGGTGTCACGTTTGGTGTCGCTAGTGGTGTCACGTTCGGTGTCGCTAGTGGTGTCACGTTCGGTGTCGCTAGTGGT

>NZ_AP018203|11|2|4238444-4238689|CRT
TTTGGTGTCGCTTTTGGT	GTCGTATTTGGTGTCGCTTTTGGTATCATGGTTGGTGTCGCA
TTTGGTGTCGCGTTTGGT	GTCGCGTTTGGTGTCGCG
TTTGGTGTCGCTAGTGGT	ATCGTGGTTGGTGTCGCTAGTGGTATCGTG
GTTGGTGTCGCTAGTGGT	ATCGTGGTTGGTGTCACG
TTTGGTGTCGCTAGTGGT	GTCACGTTCGGTGTCGCTAGTGGTGTCACG
TTCGGTGTCGCTAGTGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017288835.1|4245783_4246278_+|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl|CDD|234575
NZ_AP018203.1|WP_017288823.1|4232663_4232999_-|cation:proton-antiporter-subunit-C	unknown	unknown	gnl|CDD|236258
NZ_AP018203.1|WP_017288833.1|4244851_4245490_-|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl|CDD|377219
NZ_AP018203.1|WP_017288821.1|4230862_4231243_-|hypothetical-protein	unknown	unknown	gnl|CDD|237159
NZ_AP018203.1|WP_017288829.1|4241734_4242685_-|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NZ_AP018203.1|WP_017288826.1|4236826_4237921_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379062
NZ_AP018203.1|WP_017288830.1|4242764_4242983_-|DUF3148-domain-containing-protein	unknown	unknown	gnl|CDD|371482
NZ_AP018203.1|WP_017288818.1|4229843_4230344_-|DUF4040-domain-containing-protein	unknown	unknown	gnl|CDD|236006
NZ_AP018203.1|WP_017288822.1|4231239_4232667_-|cation:proton-antiporter	unknown	unknown	gnl|CDD|235978
NZ_AP018203.1|WP_017288828.1|4240426_4241731_-|DUF58-domain-containing-protein	unknown	unknown	gnl|CDD|224635
NZ_AP018203.1|WP_081614751.1|4238794_4240384_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379062
NZ_AP018203.1|WP_017288819.1|4230336_4230618_-|monovalent-cation/H(+)-antiporter-subunit-G	unknown	unknown	gnl|CDD|377023
NZ_AP018203.1|WP_017288832.1|4244536_4244821_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288824.1|4233452_4236029_-|DNA-gyrase-subunit-A	unknown	unknown	gnl|CDD|235502
NZ_AP018203.1|WP_017288836.1|4246466_4246913_+|diacylglycerol-kinase-family-protein	unknown	unknown	gnl|CDD|260134
NZ_AP018203.1|WP_017288820.1|4230614_4230866_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288831.1|4243156_4244524_+|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NZ_AP018203.1|WP_026148720.1|4245592_4245784_+|DUF3285-domain-containing-protein	unknown	unknown	gnl|CDD|314535
NZ_AP018203.1|WP_017288817.1|4229190_4229847_-|cation:proton-antiporter	unknown	unknown	gnl|CDD|237140
NZ_AP018203.1|WP_017288825.1|4236187_4236586_+|response-regulator	unknown	unknown	gnl|CDD|381100

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017288835.1|4245783_4246278_+|rRNA-maturation-RNase-YbeY	gnl|CDD|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	4.95648e-50
NZ_AP018203.1|WP_017288823.1|4232663_4232999_-|cation:proton-antiporter-subunit-C	gnl|CDD|236258	PRK08389, PRK08389, putative monovalent cation/H+ antiporter subunit C; Reviewed.	2.00955e-43
NZ_AP018203.1|WP_017288821.1|4230862_4231243_-|hypothetical-protein	gnl|CDD|237159	PRK12651, PRK12651, Na+/H+ antiporter subunit E.	0.000170356
NZ_AP018203.1|WP_017288829.1|4241734_4242685_-|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	9.11721e-103
NZ_AP018203.1|WP_017288826.1|4236826_4237921_+|ATP-binding-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.00102922
NZ_AP018203.1|WP_017288830.1|4242764_4242983_-|DUF3148-domain-containing-protein	gnl|CDD|371482	pfam11347, DUF3148, Protein of unknown function (DUF3148). This family of proteins has no known function.	2.2351e-37
NZ_AP018203.1|WP_017288818.1|4229843_4230344_-|DUF4040-domain-containing-protein	gnl|CDD|236006	PRK07377, PRK07377, hypothetical protein; Provisional.	2.7372e-69
NZ_AP018203.1|WP_017288822.1|4231239_4232667_-|cation:proton-antiporter	gnl|CDD|235978	PRK07234, PRK07234, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NZ_AP018203.1|WP_017288828.1|4240426_4241731_-|DUF58-domain-containing-protein	gnl|CDD|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.21813e-83
NZ_AP018203.1|WP_081614751.1|4238794_4240384_+|ATP-binding-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	2.18166e-05
NZ_AP018203.1|WP_017288819.1|4230336_4230618_-|monovalent-cation/H(+)-antiporter-subunit-G	gnl|CDD|377023	pfam03334, PhaG_MnhG_YufB, Na+/H+ antiporter subunit. This family includes PhaG from Rhizobium meliloti, MnhG from Staphylococcus aureus, YufB from Bacillus subtilis.	1.52032e-09
NZ_AP018203.1|WP_017288833.1|4244851_4245490_-|SMC-Scp-complex-subunit-ScpB	gnl|CDD|377219	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB. This is a family of prokaryotic proteins that form one of the subunits, ScpB, of the segregation and condensation complex, condensin, that plays a key role in the maintenance of the chromosome. In prokaryotes the complex consists of three proteins, SMC, ScpA (kleisin) and ScpB. ScpB dimerizes and binds to ScpA. As originally predicted, ScpB is structurally a winged-helix at both its N- and C-terminal halves. IN Bacillus subtilis,one Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complex ring-shaped assemblies.	9.13542e-42
NZ_AP018203.1|WP_017288824.1|4233452_4236029_-|DNA-gyrase-subunit-A	gnl|CDD|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NZ_AP018203.1|WP_017288836.1|4246466_4246913_+|diacylglycerol-kinase-family-protein	gnl|CDD|260134	cd14265, UDPK_IM_like, Integral membrane undecaprenol kinase and similar enzymes. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of undecaprenol to undecaprenyl phosphate. C55-isoprenyl (undecaprenyl) pyroposphate acts as a scaffold for the assembly of peptidoglycan components; undecaprenol kinase (UDPK) is involved in recycling undecaprenyl units for re-use in the peptidoglycan biosynthesis. UDPK does not participate in the de-novo biosynthesis of undecaprenyl phosphate. Gram-positive bacteria have a large pool of free undecaprenol, in contrast to gram-negative bacteria. UDPK may also play a role in a stress-induced pathway that affects the function of ribosomes. In Streptococcus mutans, UDPK has been shown to be required for biofilm formation, such as in the case of smooth surface dental caries. Members of the UDPK family have low activity as diacylglycerol kinases (DAGK), and many of them are annotated as DAGKs.	6.84116e-43
NZ_AP018203.1|WP_017288831.1|4243156_4244524_+|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	3.77427e-154
NZ_AP018203.1|WP_026148720.1|4245592_4245784_+|DUF3285-domain-containing-protein	gnl|CDD|314535	pfam11688, DUF3285, Protein of unknown function (DUF3285). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	8.40807e-24
NZ_AP018203.1|WP_017288817.1|4229190_4229847_-|cation:proton-antiporter	gnl|CDD|237140	PRK12567, PRK12567, putative monovalent cation/H+ antiporter subunit B; Reviewed.	3.80483e-97
NZ_AP018203.1|WP_017288825.1|4236187_4236586_+|response-regulator	gnl|CDD|381100	cd17548, REC_DivK-like, phosphoacceptor receiver (REC) domain of DivK and similar proteins. Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.49847e-33

Protein sequences

>NZ_AP018203.1|WP_017288826.1|4236826_4237921_+|ATP-binding-protein
MSSQTNCPFLADRMLTERKFFVGRRDQIRFILSRMTNDQPTSVNVVGDRRVGKSSLLYHIYQSYEEQVTAYGRRAEEFVVVYLSLRDGNCRKPEDFYQAVADQLLQRQRVLSNPILAQPLQQSQLNGSKFFRAMDAWKQAKVLPVVCLDNFEELLDPESQFDDGFYDNLRALQGRSEIMLIIASRRKLREYKQKGRTSEFFNVSQTEVLQDLSESEAQDLVRLPDTQNPALSEERQQLALKWADRHPYLLQLAALYLWEARQFDKSNEWAQRRFEEDARGVPRRVNPARMVFMGIGRLGQWGQQLGDTADDWGNFLKGMVTLVLLGLALTGVVKWSNFGSFMQDFAGEILKNMQTQPDQKGEGK
>NZ_AP018203.1|WP_017288825.1|4236187_4236586_+|response-regulator
MQTVLIVEDDLTNARVFSKILTKRGGLAVKHTENVDEVIEIAQSGEADIILMDVSLSRSMYQGKAMNGIQLTQLLKADEKTASLPIILVTAHAMEGDRENFLKQSGADGYISKPVVDHQAFVDQIMELLPGA
>NZ_AP018203.1|WP_017288824.1|4233452_4236029_-|DNA-gyrase-subunit-A
MARTRTQSEQLNILPSGQVIPTALHTEMQQSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRLVQDFSSRYPLLGGHGNFGSVDNDPPAAMRYTETRLSAIGNEALLTEIGESTVDFIGNFDNSQQEPTVLPAQLPILLLNGSSGIAVGMATNIPPHNMGEVVEGLIALIDRPTLSDEELLKLIPGPDFPTGGEIIDTNGIREAYLTGRGSVPIRGIANLEEIQTGRGKHRRSAIVITELPYQVNKAGLIEKIAELVNTGKIEGIGDLRDESDREGIRVVIELRRDANPQKILNFLYRQTPLQNNFGVILLALENGQPKQMSLRQMLQAFLDFRETTLTRQYRHEYDQADSQLHVVEGRLKALANLDDVIDILRNAPDGGTAKIQLQERLDLSDRQADAILSMPLRRLTGMERQSLQTEYDELLAKMDELHKLLSDRKELLKALKKDLRALKKKYGDDRRTKILSSTEVAAMEVKDKDEATTAAKSVNLAFEFEEEEQDTVVEVTQRGYVRRMTPKTYDRLSKTRNDDTVTKDLEDGDDFATQTDFTTTGKTLVVFTRNGKAFTLKVRDIPQANNNKAKGSPLVTLLPPAAQAEPDAIAATFMLPEVLDDQFVLLLTEQGKIKRLPLSEFADITGRGLTALKLKEGDQLLAANPVQVGEQVMLATSSGRVLRFEVNDLQVPVASRTSQGQTGMRVGKKERIVGWAIANEDDTFLMISEQGYAKHMEVSAMRRASTGELGTQSFHFNNKTDLVAGIVAVLPQALVFLLTNENHLARIDVDRLELRAKDERGDRVVKLAKTERITHVSLPVLFGSEEENE
>NZ_AP018203.1|WP_017288823.1|4232663_4232999_-|cation:proton-antiporter-subunit-C
MLEACVFATVLCGFFGIILKKNLVMKIISMDVMSAGVIAYYVVIAARQGTFTPILSGTTERAFADPVPQAVILTGIVIGFSIQALMLVGVMKLAKENPTLESHEIEKQNTP
>NZ_AP018203.1|WP_017288822.1|4231239_4232667_-|cation:proton-antiporter
MNILTLAWITFPFFLGFVIYLVPKLDKQLSLFGTLVSVAYALKLFTEPALNLKLLDSFGVVLTVDSLTAYFILTNAIVTIAVLFYCWQTSKLTFFYAQTLLLHASINAAFVCSDFLSLYIALEVSGIAAFLLIAYPRTDRSIWVGLRYLFTSNVAMLFYLIGTALVYKADHSFSFTGLQNAPPEAVALLFLGLLVKAGVFISGLWLPMTHSEAETPVSALLSGVVVKASLLALVRCALILDDIDTIVRIFGVATTLLGVFYAVFEKDTKRMLAFHTVSQLGFILAAPEAAGFYTLSHGLVKSSLFLLAGNLPSRNFKELQTKTISTPVWIALVIASLSISGSPLWAGFGAKVFTLKNLLPWQVIAMNVCAVGTATSFAKFIFLPHGKTEEKVRPGLIAAIVLLLGGLLFANIAYIQAYSVENIVKAFVTIGGGWLAYWVIFRRATVKLPRMLEEFEHLVGMMGLTLILLFWMALA
>NZ_AP018203.1|WP_017288821.1|4230862_4231243_-|hypothetical-protein
MIGHVLVRLVLWFLLTADFSAANIVIGLCIAFLLPRSYTAPETLREWLRSLKKILMVIPAAYQEAFEIMLHPHRHETIVKERVPAHRSPRMIFLDIFLITFTPKTIVTKHDDRGWYEVHEVRRDAS
>NZ_AP018203.1|WP_017288820.1|4230614_4230866_-|hypothetical-protein
MNILLIAMLIALLIPLYEAWKNEDIWQTMLAFASVSSKTAIIALTIAVFRDDWMIGVVAVIILSVGNAGMMLLAHILKRMNDG
>NZ_AP018203.1|WP_017288819.1|4230336_4230618_-|monovalent-cation/H(+)-antiporter-subunit-G
MINILSDILIGAGIVLWFWGTLALPTQRSVLYKLHSLSVADTLGSMTIIFGLFLRIPNRWALLLLALFCLMIWNTMLGYVLAHCSSSEEPDYD
>NZ_AP018203.1|WP_017288818.1|4229843_4230344_-|DUF4040-domain-containing-protein
MTEVNIIAVLLPIVAAMLVFQTNPYHALIIRGILGAIAALLYAVLGAGDVGLTEALMGSLLATMLYAVAVRSSFVMRLGILTEENLEPMIENVRSIMNKHYMRVELVPFRDRQDLDQALMTKEIHATCVRDSENYNTVVRIPRLYEILQNELAFPLAQLTYKGEKS
>NZ_AP018203.1|WP_017288817.1|4229190_4229847_-|cation:proton-antiporter
MKWIYLAAGLALYVKFLFMPNPAPELPFSIAETVVKESGVINAVSGIIFRNRLYDTIFEVIVFTISILGAKYLLSNEPPSKVHHFTDQASIVLARLGATICALVSIELGIRGHLSPGGGFAAGVAGGTAIGLIAITSSPEWLEAVYHKWKAAMWEKISVLVFIVLAVITLAGYELPHGEPGALISGGVLPLLNVLVAIKVALGSWAVVLLFIRYRGLL
>NZ_AP018203.1|WP_081614751.1|4238794_4240384_+|ATP-binding-protein
MSASTLRFLPPYFDQLIYFPLPFLSELIVEAHRTNPVAAESTIDYLINSTTQQKAAINAMQGIALDTLSRCKYATDITQASLILDWIPRNEEDFGAVLLQLIDLSQSIRTAYDGTTPYRKLELLDQPIAELTKLQKKLATQEFAKDATLYGSIVEQWLTILQDSRIAFAEAASQSPEIPDRYLAGNALDPLSAKGRFKGRQELFREIENISLSAQPPVLLLYGRRRTGKTSTLNYLPEKVSGDLIPLFVDFQGASSFQTFESIAEWIAEEIQKSARLSRNVILPAIDAKEIARDPFAALLQWMAKIERLVPSKRFLLCLDEFERLEEAIAANNNNRAPLNFLRYVMQNRRQWVLLFSGSHRLSELNPYWSDCLISTQTLPLTYLSPTETRELIQQPVPDFPDIYELEAVDAISNLTHGQPYLVQLTCSQVVDRLNQEILADQPHRKATAKDVQLIIPKVLERGEGYFNEFWQTQTPEQQAILKLIVQGEHITQPTHILDKFIQAEILHKQAEQYIFQVPLIHHYINSLG
>NZ_AP018203.1|WP_017288828.1|4240426_4241731_-|DUF58-domain-containing-protein
MLPSRRTYGLLLLGGAIAVIAFFFNPALAILGMLLFDLIVLALTIWDGWRVKPHRVKIERQVASRLSIGRDNLVSLSVEAGKTTAEVRIYDKYPISFGISSMPLAAKLPPNTSQQLSYTVHPSERGEYIWKDIQVRQLSPWRLAWHNWQIPQEQKVAVYPDLMGLRSLSIRLTLESSGSMRRARRMGIGTEFSELREYGIGDDPRFIDWKATARRGQPLVRVLEPEQEQTLIILLDRGRLMTSQVKGLTRFDWGLNATLALALAGLHRGDRVGVGVFDRQVQTWIPPERGQAHLNHLIERLTPIQPEMLEPDYLGAVTTLVNQQTRRALVVVITDIVDNTASSELLAALGRLTPRYLPFCVTLRDPQVDQQAHTVTEDLPATYERAVALDLIAQRQMAFSTLKQRGVLVLDAPANQITNELVDRYLQLKLKNQL
>NZ_AP018203.1|WP_017288829.1|4241734_4242685_-|MoxR-family-ATPase
MSDLQTTFSKLRQSLDQIVVGQSALIQQLLVALLSGGHVILEGVPGTGKTLTVKVMAKLVRSQFRRVQLTPDILPSDILGTNIFDLNTRSFLLKKGPVFTEILLADEINRTPPKTQSALLEAMEEQQVTLDGESLPLPDFFWVIATQNSLEFEGTYPLPEAQLDRFLFKLMAVYPDPVAEKKMLLNHQAGFQGKRLDLDNIQPVASVEQILQARREIRSLKVEESVLDYLLAVVQKTRQHPDLVLGASPRSAVAWLNVSKAQAWLSGRSYVTPDDIKAVASPLLRHRLILRPEAQLDGIGVEAVINAVLNQVAVPR
>NZ_AP018203.1|WP_017288830.1|4242764_4242983_-|DUF3148-domain-containing-protein
MKEFTIGAKVRLISLPPYLKSADPMPMLRPADILQVGDEGTVLDRRPGGYWGVRFEKGAFLLDSQYLEANAE
>NZ_AP018203.1|WP_017288831.1|4243156_4244524_+|thioredoxin-disulfide-reductase
MANPTVENLVIIGSGPAGYTAAIYAGRANLKPLVFEGFQAGGLPGGQLMTTTEVENFPGFPQGITGPQLMTQMKAQAERWGAELVTEDVLSVDFSTRPFKIRAETREVEAHSVVIATGATAKRLGLPSEHEFWSRGISACAICDGATPIFRGVPLVVIGGGDTAAEEAIYLTKYGDHVNLLVRSDVMRASKAMQDRVLSNPRITVHWNSEAIDVVGDEKHMTGVKIRNRQTGEESIIEAKGLFYAIGHTPNTALFKGQIELDEVGYIKTHGSVETNLEGVYAAGDVQDHEFRQAITAAGTGCMAAMLAERWLSANGLVQEFERIEADVPNEENTAHPASEQVIEFSLEHTRHVGGLALRKLYHESDRLILVKYASPSCGPCHTLKPILNKVVDEFDGKIHYVEIDIEEDPEIAEAAGVMGTPTIHLFKNKDKVAEVKGVKQKSQYRELITTHITD
>NZ_AP018203.1|WP_017288832.1|4244536_4244821_-|hypothetical-protein
MFATYRSSRSPALEWNSGLVEQSPLKGLTAKQNQIFSPFSGLSTVSLGIPFQGELERSEKPVDTLQTSSKASFDFTRRKSSEFFEKPGAFEFQH
>NZ_AP018203.1|WP_017288833.1|4244851_4245490_-|SMC-Scp-complex-subunit-ScpB
MTRLTTTLEAILYLKAQPMTIAQLAELAGFDRQTTEEGLMELMSDYAHRDGALEIAETDSGYSLQLRETYQNLINALIPADLGVGALRTLAVIALKGPISQTELVEIRGSGVYQHIPELVELGFVRKRKNSDGRSSLVQVTDKFHQYFQINQDIGQLIQKKPKPEESVAAETVEKVSEDSIIEESVAPETVKKVSENSVLEEPNEVEVSSVG
>NZ_AP018203.1|WP_026148720.1|4245592_4245784_+|DUF3285-domain-containing-protein
MTDLPETPTSETPISETPKEPQPSYVKLAMRNMVRKRGTSIFHFALTTIGLLGTLVVLSYLTR
>NZ_AP018203.1|WP_017288835.1|4245783_4246278_+|rRNA-maturation-RNase-YbeY
MQVELSVQDCCPQNSSIQPETWEIWFRQWLDLLKPELDGAPLHPQENYELSLRLTDDREIQSLNQNYRHKDQPTDVLAFASLEVDCPQIDELETEPLYLGDIVISVETAERQAAPHNLETELAWLAAHGLLHLLGWDHPDDASLLRMLDQQQILLNAVGLDAKR
>NZ_AP018203.1|WP_017288836.1|4246466_4246913_+|diacylglycerol-kinase-family-protein
MSQEVPTQSPKRPKVVPLVKPERDLAWQVAPTLFTSFRYAWMGVSYAFLTQRNFRIHVCLGSIAIGLGLLLHASVVELAVIGLTIGLVLAMELLNTAIESVVDLTVKQTYHELAKIAKDCAAAAVLVSAIAAVLVAGCILLPKLWLVL

Crispr_ID: NZ_AP018203_12

• CRISPR_ID: NZ_AP018203_12
• CRISPR_location: 4244919-4244999
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_12

Consensus_repeat	Method
ACGGTCTCTGGCGCAACAGATTCCTCG	CRISPRCasFinder

spacers of NZ_AP018203_12

>12.1|4244946|27|NZ_AP018203|CRISPRCasFinder
ATGATAGAGTCTTCTGAAACCTTCTCT

CRISPR arrays and Neighbor proteins around NZ_AP018203_12

CRISPR arrays

The CRISPR arrays of NZ_AP018203_12

>merge|NZ_AP018203|12|4244919-4244999|CRISPRCasFinder
ACGGTCTCTGGCGCAACAGATTCCTCGATGATAGAGTCTTCTGAAACCTTCTCTACGGTCTCTGCCGCAACAGATTCCTCG

>NZ_AP018203|12|10|4244919-4244999|CRISPRCasFinder
ACGGTCTCTGGCGCAACAGATTCCTCG	ATGATAGAGTCTTCTGAAACCTTCTCT
ACGGTCTCTGCCGCAACAGATTCCTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017288835.1|4245783_4246278_+|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl|CDD|234575
NZ_AP018203.1|WP_026148721.1|4248670_4248928_+|TIGR03643-family-protein	unknown	unknown	gnl|CDD|378528
NZ_AP018203.1|WP_017288829.1|4241734_4242685_-|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NZ_AP018203.1|WP_017288825.1|4236187_4236586_+|response-regulator	unknown	unknown	gnl|CDD|381100
NZ_AP018203.1|WP_086371005.1|4238444_4238798_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288832.1|4244536_4244821_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288828.1|4240426_4241731_-|DUF58-domain-containing-protein	unknown	unknown	gnl|CDD|224635
NZ_AP018203.1|WP_026148722.1|4251409_4252021_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_081614751.1|4238794_4240384_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379062
NZ_AP018203.1|WP_017288841.1|4250413_4250719_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017288824.1|4233452_4236029_-|DNA-gyrase-subunit-A	unknown	unknown	gnl|CDD|235502
NZ_AP018203.1|WP_017288840.1|4249007_4250318_+|M24-family-metallopeptidase	unknown	unknown	gnl|CDD|182804
NZ_AP018203.1|WP_017288836.1|4246466_4246913_+|diacylglycerol-kinase-family-protein	unknown	unknown	gnl|CDD|260134
NZ_AP018203.1|WP_017288837.1|4246967_4247564_+|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl|CDD|235552
NZ_AP018203.1|WP_017288830.1|4242764_4242983_-|DUF3148-domain-containing-protein	unknown	unknown	gnl|CDD|371482
NZ_AP018203.1|WP_017288831.1|4243156_4244524_+|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NZ_AP018203.1|WP_017288838.1|4247587_4248334_+|hypothetical-protein	unknown	unknown	gnl|CDD|316044
NZ_AP018203.1|WP_026148720.1|4245592_4245784_+|DUF3285-domain-containing-protein	unknown	unknown	gnl|CDD|314535
NZ_AP018203.1|WP_017288842.1|4250776_4251331_+|thioredoxin-family-protein	unknown	unknown	gnl|CDD|379034
NZ_AP018203.1|WP_017288826.1|4236826_4237921_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379062

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017288835.1|4245783_4246278_+|rRNA-maturation-RNase-YbeY	gnl|CDD|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	4.95648e-50
NZ_AP018203.1|WP_026148721.1|4248670_4248928_+|TIGR03643-family-protein	gnl|CDD|378528	pfam10985, DUF2805, Protein of unknown function (DUF2805). This is a bacterial family of proteins with unknown function.	1.2837e-39
NZ_AP018203.1|WP_017288829.1|4241734_4242685_-|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	9.11721e-103
NZ_AP018203.1|WP_017288826.1|4236826_4237921_+|ATP-binding-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.00102922
NZ_AP018203.1|WP_017288830.1|4242764_4242983_-|DUF3148-domain-containing-protein	gnl|CDD|371482	pfam11347, DUF3148, Protein of unknown function (DUF3148). This family of proteins has no known function.	2.2351e-37
NZ_AP018203.1|WP_017288828.1|4240426_4241731_-|DUF58-domain-containing-protein	gnl|CDD|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.21813e-83
NZ_AP018203.1|WP_081614751.1|4238794_4240384_+|ATP-binding-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	2.18166e-05
NZ_AP018203.1|WP_017288842.1|4250776_4251331_+|thioredoxin-family-protein	gnl|CDD|379034	pfam13098, Thioredoxin_2, Thioredoxin-like domain.	3.58968e-06
NZ_AP018203.1|WP_017288824.1|4233452_4236029_-|DNA-gyrase-subunit-A	gnl|CDD|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NZ_AP018203.1|WP_017288840.1|4249007_4250318_+|M24-family-metallopeptidase	gnl|CDD|182804	PRK10879, PRK10879, proline aminopeptidase P II; Provisional.	1.17813e-138
NZ_AP018203.1|WP_017288836.1|4246466_4246913_+|diacylglycerol-kinase-family-protein	gnl|CDD|260134	cd14265, UDPK_IM_like, Integral membrane undecaprenol kinase and similar enzymes. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of undecaprenol to undecaprenyl phosphate. C55-isoprenyl (undecaprenyl) pyroposphate acts as a scaffold for the assembly of peptidoglycan components; undecaprenol kinase (UDPK) is involved in recycling undecaprenyl units for re-use in the peptidoglycan biosynthesis. UDPK does not participate in the de-novo biosynthesis of undecaprenyl phosphate. Gram-positive bacteria have a large pool of free undecaprenol, in contrast to gram-negative bacteria. UDPK may also play a role in a stress-induced pathway that affects the function of ribosomes. In Streptococcus mutans, UDPK has been shown to be required for biofilm formation, such as in the case of smooth surface dental caries. Members of the UDPK family have low activity as diacylglycerol kinases (DAGK), and many of them are annotated as DAGKs.	6.84116e-43
NZ_AP018203.1|WP_017288837.1|4246967_4247564_+|aminodeoxychorismate/anthranilate-synthase-component-II	gnl|CDD|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	8.85389e-126
NZ_AP018203.1|WP_017288838.1|4247587_4248334_+|hypothetical-protein	gnl|CDD|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	3.00261e-66
NZ_AP018203.1|WP_017288831.1|4243156_4244524_+|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	3.77427e-154
NZ_AP018203.1|WP_026148720.1|4245592_4245784_+|DUF3285-domain-containing-protein	gnl|CDD|314535	pfam11688, DUF3285, Protein of unknown function (DUF3285). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	8.40807e-24
NZ_AP018203.1|WP_017288825.1|4236187_4236586_+|response-regulator	gnl|CDD|381100	cd17548, REC_DivK-like, phosphoacceptor receiver (REC) domain of DivK and similar proteins. Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.49847e-33

Protein sequences

>NZ_AP018203.1|WP_017288832.1|4244536_4244821_-|hypothetical-protein
MFATYRSSRSPALEWNSGLVEQSPLKGLTAKQNQIFSPFSGLSTVSLGIPFQGELERSEKPVDTLQTSSKASFDFTRRKSSEFFEKPGAFEFQH
>NZ_AP018203.1|WP_017288831.1|4243156_4244524_+|thioredoxin-disulfide-reductase
MANPTVENLVIIGSGPAGYTAAIYAGRANLKPLVFEGFQAGGLPGGQLMTTTEVENFPGFPQGITGPQLMTQMKAQAERWGAELVTEDVLSVDFSTRPFKIRAETREVEAHSVVIATGATAKRLGLPSEHEFWSRGISACAICDGATPIFRGVPLVVIGGGDTAAEEAIYLTKYGDHVNLLVRSDVMRASKAMQDRVLSNPRITVHWNSEAIDVVGDEKHMTGVKIRNRQTGEESIIEAKGLFYAIGHTPNTALFKGQIELDEVGYIKTHGSVETNLEGVYAAGDVQDHEFRQAITAAGTGCMAAMLAERWLSANGLVQEFERIEADVPNEENTAHPASEQVIEFSLEHTRHVGGLALRKLYHESDRLILVKYASPSCGPCHTLKPILNKVVDEFDGKIHYVEIDIEEDPEIAEAAGVMGTPTIHLFKNKDKVAEVKGVKQKSQYRELITTHITD
>NZ_AP018203.1|WP_017288830.1|4242764_4242983_-|DUF3148-domain-containing-protein
MKEFTIGAKVRLISLPPYLKSADPMPMLRPADILQVGDEGTVLDRRPGGYWGVRFEKGAFLLDSQYLEANAE
>NZ_AP018203.1|WP_017288829.1|4241734_4242685_-|MoxR-family-ATPase
MSDLQTTFSKLRQSLDQIVVGQSALIQQLLVALLSGGHVILEGVPGTGKTLTVKVMAKLVRSQFRRVQLTPDILPSDILGTNIFDLNTRSFLLKKGPVFTEILLADEINRTPPKTQSALLEAMEEQQVTLDGESLPLPDFFWVIATQNSLEFEGTYPLPEAQLDRFLFKLMAVYPDPVAEKKMLLNHQAGFQGKRLDLDNIQPVASVEQILQARREIRSLKVEESVLDYLLAVVQKTRQHPDLVLGASPRSAVAWLNVSKAQAWLSGRSYVTPDDIKAVASPLLRHRLILRPEAQLDGIGVEAVINAVLNQVAVPR
>NZ_AP018203.1|WP_017288828.1|4240426_4241731_-|DUF58-domain-containing-protein
MLPSRRTYGLLLLGGAIAVIAFFFNPALAILGMLLFDLIVLALTIWDGWRVKPHRVKIERQVASRLSIGRDNLVSLSVEAGKTTAEVRIYDKYPISFGISSMPLAAKLPPNTSQQLSYTVHPSERGEYIWKDIQVRQLSPWRLAWHNWQIPQEQKVAVYPDLMGLRSLSIRLTLESSGSMRRARRMGIGTEFSELREYGIGDDPRFIDWKATARRGQPLVRVLEPEQEQTLIILLDRGRLMTSQVKGLTRFDWGLNATLALALAGLHRGDRVGVGVFDRQVQTWIPPERGQAHLNHLIERLTPIQPEMLEPDYLGAVTTLVNQQTRRALVVVITDIVDNTASSELLAALGRLTPRYLPFCVTLRDPQVDQQAHTVTEDLPATYERAVALDLIAQRQMAFSTLKQRGVLVLDAPANQITNELVDRYLQLKLKNQL
>NZ_AP018203.1|WP_081614751.1|4238794_4240384_+|ATP-binding-protein
MSASTLRFLPPYFDQLIYFPLPFLSELIVEAHRTNPVAAESTIDYLINSTTQQKAAINAMQGIALDTLSRCKYATDITQASLILDWIPRNEEDFGAVLLQLIDLSQSIRTAYDGTTPYRKLELLDQPIAELTKLQKKLATQEFAKDATLYGSIVEQWLTILQDSRIAFAEAASQSPEIPDRYLAGNALDPLSAKGRFKGRQELFREIENISLSAQPPVLLLYGRRRTGKTSTLNYLPEKVSGDLIPLFVDFQGASSFQTFESIAEWIAEEIQKSARLSRNVILPAIDAKEIARDPFAALLQWMAKIERLVPSKRFLLCLDEFERLEEAIAANNNNRAPLNFLRYVMQNRRQWVLLFSGSHRLSELNPYWSDCLISTQTLPLTYLSPTETRELIQQPVPDFPDIYELEAVDAISNLTHGQPYLVQLTCSQVVDRLNQEILADQPHRKATAKDVQLIIPKVLERGEGYFNEFWQTQTPEQQAILKLIVQGEHITQPTHILDKFIQAEILHKQAEQYIFQVPLIHHYINSLG
>NZ_AP018203.1|WP_086371005.1|4238444_4238798_+|hypothetical-protein
MVSLLVSYLVSLLVSWLVSHLVSRLVSRLVSRLVSLVVSWLVSLVVSWLVSLVVSWLVSRLVSLVVSRSVSLVVSRSVSLVVSWLVSRGSWVQSEPISGYQNSSGCWDWGFLLVMPM
>NZ_AP018203.1|WP_017288826.1|4236826_4237921_+|ATP-binding-protein
MSSQTNCPFLADRMLTERKFFVGRRDQIRFILSRMTNDQPTSVNVVGDRRVGKSSLLYHIYQSYEEQVTAYGRRAEEFVVVYLSLRDGNCRKPEDFYQAVADQLLQRQRVLSNPILAQPLQQSQLNGSKFFRAMDAWKQAKVLPVVCLDNFEELLDPESQFDDGFYDNLRALQGRSEIMLIIASRRKLREYKQKGRTSEFFNVSQTEVLQDLSESEAQDLVRLPDTQNPALSEERQQLALKWADRHPYLLQLAALYLWEARQFDKSNEWAQRRFEEDARGVPRRVNPARMVFMGIGRLGQWGQQLGDTADDWGNFLKGMVTLVLLGLALTGVVKWSNFGSFMQDFAGEILKNMQTQPDQKGEGK
>NZ_AP018203.1|WP_017288825.1|4236187_4236586_+|response-regulator
MQTVLIVEDDLTNARVFSKILTKRGGLAVKHTENVDEVIEIAQSGEADIILMDVSLSRSMYQGKAMNGIQLTQLLKADEKTASLPIILVTAHAMEGDRENFLKQSGADGYISKPVVDHQAFVDQIMELLPGA
>NZ_AP018203.1|WP_017288824.1|4233452_4236029_-|DNA-gyrase-subunit-A
MARTRTQSEQLNILPSGQVIPTALHTEMQQSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRLVQDFSSRYPLLGGHGNFGSVDNDPPAAMRYTETRLSAIGNEALLTEIGESTVDFIGNFDNSQQEPTVLPAQLPILLLNGSSGIAVGMATNIPPHNMGEVVEGLIALIDRPTLSDEELLKLIPGPDFPTGGEIIDTNGIREAYLTGRGSVPIRGIANLEEIQTGRGKHRRSAIVITELPYQVNKAGLIEKIAELVNTGKIEGIGDLRDESDREGIRVVIELRRDANPQKILNFLYRQTPLQNNFGVILLALENGQPKQMSLRQMLQAFLDFRETTLTRQYRHEYDQADSQLHVVEGRLKALANLDDVIDILRNAPDGGTAKIQLQERLDLSDRQADAILSMPLRRLTGMERQSLQTEYDELLAKMDELHKLLSDRKELLKALKKDLRALKKKYGDDRRTKILSSTEVAAMEVKDKDEATTAAKSVNLAFEFEEEEQDTVVEVTQRGYVRRMTPKTYDRLSKTRNDDTVTKDLEDGDDFATQTDFTTTGKTLVVFTRNGKAFTLKVRDIPQANNNKAKGSPLVTLLPPAAQAEPDAIAATFMLPEVLDDQFVLLLTEQGKIKRLPLSEFADITGRGLTALKLKEGDQLLAANPVQVGEQVMLATSSGRVLRFEVNDLQVPVASRTSQGQTGMRVGKKERIVGWAIANEDDTFLMISEQGYAKHMEVSAMRRASTGELGTQSFHFNNKTDLVAGIVAVLPQALVFLLTNENHLARIDVDRLELRAKDERGDRVVKLAKTERITHVSLPVLFGSEEENE
>NZ_AP018203.1|WP_026148720.1|4245592_4245784_+|DUF3285-domain-containing-protein
MTDLPETPTSETPISETPKEPQPSYVKLAMRNMVRKRGTSIFHFALTTIGLLGTLVVLSYLTR
>NZ_AP018203.1|WP_017288835.1|4245783_4246278_+|rRNA-maturation-RNase-YbeY
MQVELSVQDCCPQNSSIQPETWEIWFRQWLDLLKPELDGAPLHPQENYELSLRLTDDREIQSLNQNYRHKDQPTDVLAFASLEVDCPQIDELETEPLYLGDIVISVETAERQAAPHNLETELAWLAAHGLLHLLGWDHPDDASLLRMLDQQQILLNAVGLDAKR
>NZ_AP018203.1|WP_017288836.1|4246466_4246913_+|diacylglycerol-kinase-family-protein
MSQEVPTQSPKRPKVVPLVKPERDLAWQVAPTLFTSFRYAWMGVSYAFLTQRNFRIHVCLGSIAIGLGLLLHASVVELAVIGLTIGLVLAMELLNTAIESVVDLTVKQTYHELAKIAKDCAAAAVLVSAIAAVLVAGCILLPKLWLVL
>NZ_AP018203.1|WP_017288837.1|4246967_4247564_+|aminodeoxychorismate/anthranilate-synthase-component-II
MILVIDNYDSFTYNLVQYLGELGEEFAIASDIQVYRNDQITLDQVRALQPDAIVISPGPGRPEDAGISMELIRQLGANTPILGVCLGHQSIGQVFGGEIVSAPVLMHGKTSEVKHTDTGVFEGLDNPMTATRYHSLVIDRSSCPAVLEITAWVEDQTIMGVRHREYPHIQGVQFHPESVLTSSGKQLLRNFLRSIQGQ
>NZ_AP018203.1|WP_017288838.1|4247587_4248334_+|hypothetical-protein
MKRRQFIQYAGAGLVAGAVPIAAQAQSGGLTVQYLGHMCFLFTGGGRRILVNPFRSAGCTAGYRAPKVAADLVMISSQILDEGAIDVVPGNPKLLVESGAYDINGFKAQGIAMDHDRVGGKRFGRNIAWRWSQGGLNVVHLGGAAAPITLEQKILIGSPDVVFLPVGGGAKAYDPQEAKQALQVLNAKIIVPMYYRTAAAKEQCDIGGLDAFLSVMSGTPLRKGGSSISLTKANLPKEGSVIQVMTYA
>NZ_AP018203.1|WP_026148721.1|4248670_4248928_+|TIGR03643-family-protein
MKLPDLDSETIDRILEMAWEDRTPFEAIALQFGLDEPQTIALMRREMKRSSFEMWRKRVTGRKTKHLKQRDFVEGRFRSQNQKGS
>NZ_AP018203.1|WP_017288840.1|4249007_4250318_+|M24-family-metallopeptidase
MLHSEFQQRRDRYLAKIGNGTAIFRSAPMAVMHNDVEYNFRQDSDFYYLTGFNEADAVAVFAPWHEEHKFILFVQPKDRDKETWTGYRIGVEAAKELYGADEAYPITELNEKLGQYVTKAEKLYYHFGRDRTFNDLVLRLWQRCVALYERNGVGPTSIEDPSFTLHPMRQVKSEYELSEMRRAVEIAAEAHNLALKIRKPGMYEYEIQAEMEHLFRLRGGQGIAYPSIVASGKNSCILHYTENDRQMQDGELLLIDAGCSYNYYNSDITRTYPVGNQFTEEQRILYELVLKAQLAAIEQVKPGKPWNEFHDASVRVITEGLLELGLLQGDIEEIIKEEKYKAFFMHGTGHWLGLDVHDAGARKVGETWLNFQPGQVVTVEPGIYIREDFQPLEGQPEISDRWRGIGIRIEDDVLVTETSNEILTAAVPKSLEAMER
>NZ_AP018203.1|WP_017288841.1|4250413_4250719_+|hypothetical-protein
MGSTAQFGLICFVIFFIFSQAFEWASEIKLPLPIFILGGAFLAIASNFDRRAGFPFNLLNTVPPPEEPLIPSAPPTIAQSSTPKFPQEVSFTIRKPEKLDQ
>NZ_AP018203.1|WP_017288842.1|4250776_4251331_+|thioredoxin-family-protein
MLNRLVSVFIAVFIVCFTIAQPAWASLTDDRYDGEIFALYAGNGSLVPPKVTLADSFNQKKPALLVFYTDDSSDCKQYTNIVSQTQAFYGRVIDILPIRVDSLPIKAKFDPKEPGYYYKGFVPQTVLFDQNGKVRLNEIGSIPYEKIDDEFRKVFDLLPRSESVILKRRPVNEINSELVPQSKS
>NZ_AP018203.1|WP_026148722.1|4251409_4252021_+|hypothetical-protein
MPQIYSTEELIQILSRERHACMNGQRLNLAAMPSGINPLLDRFVNSDGIQRFTAYRDFRTAIHHYQIEHQVSGIVWSSMTINGRTCTCPKIHEHLISLPSDLAILRAEKLKIVQFWQDITTELDLYLSMNSGKLYQLIAQEDIDRILHRSEWAVLSQQGKDETLELILQLGWGKPEEAVYRRGFPESGSEYIHAVQPGYVPIG

Crispr_ID: NZ_AP018203_13

• CRISPR_ID: NZ_AP018203_13
• CRISPR_location: 4985788-4986344
• CRISPR_type: TypeV-U5
• Repeat_type: NA
• Spacer_info: 7 spacers
• Cas_protein_info: c2c5_V-U5

Consensus repeat of NZ_AP018203_13

Consensus_repeat	Method
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CRISPRCasFinder
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CRT
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	PILER-CR

spacers of NZ_AP018203_13

>13.1|4985825|36|NZ_AP018203|CRISPRCasFinder,CRT
ATGTTGATACTGCTCGTTGACGGCAATAACCTTGCC
>13.2|4985898|36|NZ_AP018203|CRISPRCasFinder,CRT
TTTATCCCCAACGCCTCAGCAATACTTTCGACTGAG
>13.3|4985971|37|NZ_AP018203|CRISPRCasFinder,CRT
GTTCTCTGATATTGCGTCAGAAACTTTCTCATACTTT
>13.4|4986045|43|NZ_AP018203|CRISPRCasFinder,CRT
TTGAGTGAATTGCTTGTGCAGGCTTAAGTCTGTTTGGCTTCTC
>13.5|4986125|36|NZ_AP018203|CRISPRCasFinder,CRT
CGCAGTCGAGGGATATCTTTCAGATAAATTCCTAGC
>13.6|4986198|37|NZ_AP018203|CRISPRCasFinder,CRT
CTAAGCAGCGATCGCATATCATGCCTAGTTAAGGGGA
>13.7|4986272|36|NZ_AP018203|CRISPRCasFinder,CRT
CGGGCATTTGCCGAGTTGTGCAGGGAGTTTCCGAAT
>13.8|4985827|36|NZ_AP018203|PILER-CR
ATGTTGATACTGCTCGTTGACGGCAATAACCTTGCC
>13.9|4985900|36|NZ_AP018203|PILER-CR
TTTATCCCCAACGCCTCAGCAATACTTTCGACTGAG
>13.10|4985973|37|NZ_AP018203|PILER-CR
GTTCTCTGATATTGCGTCAGAAACTTTCTCATACTTT
>13.11|4986047|43|NZ_AP018203|PILER-CR
TTGAGTGAATTGCTTGTGCAGGCTTAAGTCTGTTTGGCTTCTC
>13.12|4986127|36|NZ_AP018203|PILER-CR
CGCAGTCGAGGGATATCTTTCAGATAAATTCCTAGC
>13.13|4986200|37|NZ_AP018203|PILER-CR
CTAAGCAGCGATCGCATATCATGCCTAGTTAAGGGGA
>13.14|4986274|36|NZ_AP018203|PILER-CR
CGGGCATTTGCCGAGTTGTGCAGGGAGTTTCCGAAT

CRISPR arrays and Neighbor proteins around NZ_AP018203_13

CRISPR arrays

The CRISPR arrays of NZ_AP018203_13

>merge|NZ_AP018203|13|4985788-4986344|CRISPRCasFinder,CRT,PILER-CR
TCTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACATGTTGATACTGCTCGTTGACGGCAATAACCTTGCCCTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACTTTATCCCCAACGCCTCAGCAATACTTTCGACTGAGCTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACGTTCTCTGATATTGCGTCAGAAACTTTCTCATACTTTCTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACTTGAGTGAATTGCTTGTGCAGGCTTAAGTCTGTTTGGCTTCTCCTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACCGCAGTCGAGGGATATCTTTCAGATAAATTCCTAGCCTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACCTAAGCAGCGATCGCATATCATGCCTAGTTAAGGGGACTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACCGGGCATTTGCCGAGTTGTGCAGGGAGTTTCCGAATCTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC

>NZ_AP018203|13|11|4985788-4986344|CRISPRCasFinder
TCTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	ATGTTGATACTGCTCGTTGACGGCAATAACCTTGCC
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	TTTATCCCCAACGCCTCAGCAATACTTTCGACTGAG
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	GTTCTCTGATATTGCGTCAGAAACTTTCTCATACTTT
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	TTGAGTGAATTGCTTGTGCAGGCTTAAGTCTGTTTGGCTTCTC
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CGCAGTCGAGGGATATCTTTCAGATAAATTCCTAGC
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CTAAGCAGCGATCGCATATCATGCCTAGTTAAGGGGA
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CGGGCATTTGCCGAGTTGTGCAGGGAGTTTCCGAAT
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC

>NZ_AP018203|13|3|4985788-4986344|CRT
TCTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	ATGTTGATACTGCTCGTTGACGGCAATAACCTTGCC
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	TTTATCCCCAACGCCTCAGCAATACTTTCGACTGAG
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	GTTCTCTGATATTGCGTCAGAAACTTTCTCATACTTT
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	TTGAGTGAATTGCTTGTGCAGGCTTAAGTCTGTTTGGCTTCTC
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CGCAGTCGAGGGATATCTTTCAGATAAATTCCTAGC
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CTAAGCAGCGATCGCATATCATGCCTAGTTAAGGGGA
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC	CGGGCATTTGCCGAGTTGTGCAGGGAGTTTCCGAAT
CTTTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC

>NZ_AP018203|13|3|4985790-4986344|PILER-CR
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACAT	GTTGATACTGCTCGTTGACGGCAATAACCTTGCCCT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACTT	TATCCCCAACGCCTCAGCAATACTTTCGACTGAGCT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACGT	TCTCTGATATTGCGTCAGAAACTTTCTCATACTTTCT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACTT	GAGTGAATTGCTTGTGCAGGCTTAAGTCTGTTTGGCTTCTCCT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACCG	CAGTCGAGGGATATCTTTCAGATAAATTCCTAGCCT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACCT	AAGCAGCGATCGCATATCATGCCTAGTTAAGGGGACT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAACCG	GGCATTTGCCGAGTTGTGCAGGGAGTTTCCGAATCT
TTCAATCGCCCCCTTGCCGCAAACCTGGATGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017289540.1|4995599_4996064_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017289542.1|5000585_5001995_-|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl|CDD|238192
NZ_AP018203.1|WP_017289527.1|4980572_4980968_-|30S-ribosomal-protein-S11	unknown	unknown	gnl|CDD|180007
NZ_AP018203.1|WP_017289528.1|4981046_4981430_-|30S-ribosomal-protein-S13	unknown	unknown	gnl|CDD|235358
NZ_AP018203.1|WP_017289530.1|4982276_4983587_-|cytosine-deaminase	unknown	unknown	gnl|CDD|236062
NZ_AP018203.1|WP_017289532.1|4984309_4985098_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017289525.1|4979186_4979537_-|50S-ribosomal-protein-L17	unknown	unknown	gnl|CDD|235522
NZ_AP018203.1|WP_071596180.1|4981526_4981640_-|50S-ribosomal-protein-L36	unknown	unknown	gnl|CDD|179039
NZ_AP018203.1|WP_086370989.1|4991403_4994370_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|378942
NZ_AP018203.1|WP_017289541.1|4996370_5000591_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|350195
NZ_AP018203.1|WP_036044772.1|4979545_4980517_-|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl|CDD|235359
NZ_AP018203.1|WP_017289531.1|4983689_4984313_+|precorrin-8X-methylmutase	unknown	unknown	gnl|CDD|180325
NZ_AP018203.1|WP_017289533.1|4986352_4986583_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017289537.1|4990040_4991237_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017289524.1|4978342_4979185_-|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl|CDD|234577
NZ_AP018203.1|WP_017289535.1|4988856_4989189_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017289534.1|4986775_4988686_-|hypothetical-protein	c2c5_V-U5	-	unknown
NZ_AP018203.1|WP_017289536.1|4989294_4989984_+|hypothetical-protein	unknown	unknown	gnl|CDD|273040
NZ_AP018203.1|WP_017289539.1|4994384_4995599_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_026148794.1|4981722_4981953_-|translation-initiation-factor-IF-1	unknown	unknown	gnl|CDD|178954

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP018203.1|WP_017289534.1|4986775_4988686_-|hypothetical-protein	c2c5_V-U5	-	2e-278	919.6	22.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017289542.1|5000585_5001995_-|DNA-(cytosine-5-)-methyltransferase	gnl|CDD|238192	cd00315, Cyt_C5_DNA_methylase, Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.	2.44432e-53
NZ_AP018203.1|WP_017289527.1|4980572_4980968_-|30S-ribosomal-protein-S11	gnl|CDD|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	2.8116e-83
NZ_AP018203.1|WP_017289528.1|4981046_4981430_-|30S-ribosomal-protein-S13	gnl|CDD|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	2.13477e-77
NZ_AP018203.1|WP_026148794.1|4981722_4981953_-|translation-initiation-factor-IF-1	gnl|CDD|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	4.77311e-47
NZ_AP018203.1|WP_017289530.1|4982276_4983587_-|cytosine-deaminase	gnl|CDD|236062	PRK07583, PRK07583, cytosine deaminase.	0
NZ_AP018203.1|WP_017289525.1|4979186_4979537_-|50S-ribosomal-protein-L17	gnl|CDD|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	1.1035e-57
NZ_AP018203.1|WP_071596180.1|4981526_4981640_-|50S-ribosomal-protein-L36	gnl|CDD|179039	PRK00465, rpmJ, 50S ribosomal protein L36; Reviewed.	5.60029e-12
NZ_AP018203.1|WP_017289541.1|4996370_5000591_+|AAA-family-ATPase	gnl|CDD|350195	cd18808, SF1_C_Upf1, C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	9.22008e-24
NZ_AP018203.1|WP_036044772.1|4979545_4980517_-|DNA-directed-RNA-polymerase-subunit-alpha	gnl|CDD|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	2.33503e-151
NZ_AP018203.1|WP_017289531.1|4983689_4984313_+|precorrin-8X-methylmutase	gnl|CDD|180325	PRK05953, PRK05953, Precorrin-8X methylmutase.	1.92426e-134
NZ_AP018203.1|WP_086370989.1|4991403_4994370_-|tetratricopeptide-repeat-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.02784e-44
NZ_AP018203.1|WP_017289524.1|4978342_4979185_-|tRNA-pseudouridine(38-40)-synthase-TruA	gnl|CDD|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	1.23118e-118
NZ_AP018203.1|WP_017289536.1|4989294_4989984_+|hypothetical-protein	gnl|CDD|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	3.01104e-05

Protein sequences

>NZ_AP018203.1|WP_017289532.1|4984309_4985098_-|hypothetical-protein
MLVPLSRKKFEDLIPLVGTGAQYKYYWGKLSDVLRRVLISISAVAGALLIRAFFATGELQDVVQAVTFFLIILALVYWLWSPAIQAAVRNAGYRRYKYAGFLRGEVLDVFVTDELVGTEESVNNRGELVVTENRERRINVVVGDETGFETRIQVPLKREHQAIRIGDTAEMLALSDRPDLGRIAKVSDIFVSRVGVWVSDYPYLRRDEFEAVSRQINTIEPEDDYREPPRSKRNERRWDEEYDEPRPRKRIPKSKRRSSDWD
>NZ_AP018203.1|WP_017289531.1|4983689_4984313_+|precorrin-8X-methylmutase
MEWHPTDAQSLALIDREVGDHMLSPAEYEIVRRVIYATADFDYKSLIHFSDLALQSGAAALAARTTIIVDVPMVQVGINTNIQNTFANPIYCSMEAITRPQKEKTRAAWGIETLARRYPEGIFVVGQSQTALITLAALIQKEEIKPTLVIATPSGFLDIEAAKARLSNALVPNICTQGRKGNAVVAAAIVNSLVDLAWQAYGGDNAV
>NZ_AP018203.1|WP_017289530.1|4982276_4983587_-|cytosine-deaminase
MIFDAHHYWIRNAHVPASLVVNGNKWATRKPPTDHLLHVDLEIVEGVISAILAAGTYQNYVYPSIDLQGGMIWACFADLHTHLDKGHIWNRAPNPDGTFESALNTVRVDAQKNWNPDDIYRRMEFGLKCSYAHGTKAIRTHLDSAGKLGEMSFEIFRALRDQWADRIILQAVCLVSLDYFLTPEGEKLADLVAESDGILGGVSFINPDIDQQIDRIFSMAKDRKLNLDFHVDENNDPDSNTLRRIAEAAIRHRYRNKTVCGHCCSLAVQDAAEAETTIALVKKAGIGVVSLPMCNLYLQDRTPNRTPRWRGVTLLHELKQAKVPVAIASDNCRDPFHAYGDHDALEVFSQSVKIAQLDRPFGDWANAITSTPADLMGLPNVGRIGVGLPADLVLFKARNYGELLSRSQHDRIVLRNGKAIDTTLPSYAELDDLAKP
>NZ_AP018203.1|WP_026148794.1|4981722_4981953_-|translation-initiation-factor-IF-1
MSKQDLIEMEGTVVDSLPNAMFRVDLDNGFNVLAHISGKIRRNYIKILPGDRVKVELTPYDLTKGRITYRLKNKGR
>NZ_AP018203.1|WP_071596180.1|4981526_4981640_-|50S-ribosomal-protein-L36
MKVRASVKRICEKCRVIRRKGRVMVICENPKHKQRQG
>NZ_AP018203.1|WP_017289528.1|4981046_4981430_-|30S-ribosomal-protein-S13
MARIAGVDLPRDKRVEIGLRYIYGIGPTRSKEIIAKTGVNPDTRVKDLSEADVAALREAVEGGYQIEGDLRRFESMSIKRLMDIGCYRGRRHRMGLPVRGQRTRTNARTRRGGRRTVAGKKKAPGKK
>NZ_AP018203.1|WP_017289527.1|4980572_4980968_-|30S-ribosomal-protein-S11
MARQPQRKTGPRKAKKNIPSGVAHIQSTFNNTIVTISDTQGEVISWASAGSSGFKGAKKGTPFAAQTAAEAAARRAIDQGMRQLEVMVSGPGAGRETAIRALQGTGLEITLIRDVTPIPHNGCRPPKRRRV
>NZ_AP018203.1|WP_036044772.1|4979545_4980517_-|DNA-directed-RNA-polymerase-subunit-alpha
MSSARKKEGYSVAQFQVECIDTSTEEDQSQYSKFVLEPLERGQGTTVGNALRRVLLSNLEGAAVTAVRIAGVTHEFATIPGVREDVLDILLNMKKLVFRTYSSQPQIGRLLVQGQSTVTAENFDLPSEVELVDPTQYIATLSPNATLEMEFKIEKGKGYRGAGKFTDDTALDFLQIDSVFMPVRKVQYSVEDARQGGTAEKDRLIMEIWTNGSLTPQEALSQAANILVDLFNPLKDITFEPSDDDGMSDERIENQIPIEELQLSVRAYNCLKRAQINSVADLLDYSQEDLLEIKNFGAKSAEEVVEALQQRLGITLPQEKSKS
>NZ_AP018203.1|WP_017289525.1|4979186_4979537_-|50S-ribosomal-protein-L17
MRHGCKVPLLGKPADQRKALLRALTTELIRNGRIKTTKIRAQAVRSEAEKMITLAKDGSLAARRQAMGYIYDKQLVHALFENAPERYADRQGGYTRILRTVRRRGDNAEMAIIELT
>NZ_AP018203.1|WP_017289524.1|4978342_4979185_-|tRNA-pseudouridine(38-40)-synthase-TruA
MAPAQPSLQRIALLIQYLGTRFYGWQRQPNHRSVQEEIETAIASVVGYPVVIHAAGRTDTGVHAAAQVAHFDVMTLIPAHRWADVINARLPDDVLIRASAQVPADWHARFSASWRRYRYTIYTEARPNLFARSLSWHYYHAPLDESKMQQALAPMIGRHHMSAFQRANSSRPHAWVDLQFAECVRQDSFLYIEVQASGFLYGMMRLLVGLLVEVGRGDRSVESFTQLWQNERRHEVRYAAPPQGLCLLRVGYPDMPFPPELWFDAQPKLNLSRMTLEPSL
>NZ_AP018203.1|WP_017289533.1|4986352_4986583_-|hypothetical-protein
MLVSQSHLRARRNPPLTFNLLANRSEVKIPRRFANPYKLIPSAAFHSIKLLLVQQKVSDLEGFAKTMFEKHTMAAP
>NZ_AP018203.1|WP_017289534.1|4986775_4988686_-|hypothetical-protein
MSVITIQCKLVATEETRRALWHLMAEKHTPLINELLKHIAQDSRFEEWSLTGKLPRLVVSEACNQLKQDPQFSGQPGRFYSSAISTVHRIFLSWLALQTRLRNQISGQTRWLAMLQSDNELTIASQTDINTLRLKASELLTHLNEPISESDQPEVKKTRSKKKNQTSNQAGANVSRTLFKLYDETEDPLTRCAIAYLLKNGCKLPDQNENPEKFIKRRRKTEIRLERLMNTFQTTRIPRGRHLSWHSWIEALETATSHIPENEEEAAGWQARLLTKPAILPFPVNYETNEDLRWSLNSQGRICVSFNGLSEHFFEVYCDQRDLHWFNRFLEDQETKKASKNQHSSSLFSLRSGQIAWQEGKGDAEHWVVHRLVLSCSIETDTWTQEGTEEIRQKKASDCAKVIASTKAKENRSQNQDAFIRRRERMLELLENQFPRPSYPLYQGQPSILAGVSYGLDKPATLAIVNIQTGKAITYRSIRQILGKNYKLLNRYRLNQQRNAHKRHNNQRKGGSSQLRESNQGQYLDRLIAHEIVAIAQEYQVSSLALPDLGDIREIVQSEVQARAEQKILGSIEQQRKYARQYRASVHRWRYAQLTQFIQSQAAQVGISIEITKQPLSGTPQEKARNLAIAAYQSRK
>NZ_AP018203.1|WP_017289535.1|4988856_4989189_+|hypothetical-protein
MPLAPRLPTHRHWNTLNAYLRPLGDKQMEIDEFLNNWDVSREELAFICDCSLTTVNHWFSQGEHRRIPTDKHKQRLALAHHIWITIESEPEYLQTLRQMYHKQRRREEKE
>NZ_AP018203.1|WP_017289536.1|4989294_4989984_+|hypothetical-protein
MRGKLFGLEAVNICEQKAIPSIWVTWLSRLMADESQCVWSVWFRTHFKYEKLNTNFDSAKWNANHRVLVNDRINILETEGYTVYVEGENRFEVLGRAHLVKVAGKPDIIAIKDDYAWVEDCKTGQRKNSDFYQILIYLLLLPVSLAPCQGLSLKGRLIYSDEVVEIQAEQVNENFREQFRAAIAILSSSIPARKVPSFQECRFCDISTAYCPERSENHLEQNSSEHGLF
>NZ_AP018203.1|WP_017289537.1|4990040_4991237_-|hypothetical-protein
MGLITGQYKAYGGVIRWAAGTGHGGQIVRHILPASSQVLNLIPGLNFIPGIVNSMQMSDLKDTVQQNTVLLTQLSSQVGSLSQTTQQVLQIATGTAVLSGLGLVVSSVGFIAINNKLSKIDDRLKSIQKDIQDIQHFLASNERAKLFASLDALTKLDKTPIDHRYTILHDSRRTLSEINMRYRELLLSATTIETAMAYEEYFTLTALAQARCSAELGMLDVAQHEIQETNQIWQTQGRRIAKEILVGEYPERFLASDFVDAVSVAELVEWLDFANEETKRYSWIDDLRRKVDETWYSTGWIPVLHGGSGLNKNIGIGLEKERTMIIPSLRKLAARSNVLEGYVAQYDLLVSHDLTPTEFEHKVAALPESSAVDGYFILEPTEKATPKRLPFQIPMKTR
>NZ_AP018203.1|WP_086370989.1|4991403_4994370_-|tetratricopeptide-repeat-protein
MTELSAPEPMDNFNELLEQGIKALEHDNYERALWFLDKAILLNPHNHKAWNSLGNSLYYLKRYQKALISFEQSIKIKPDSYNPWNGRGNALRELGRCKEAIDSYDQSIRLNPDDREPWNGRGNALYDLGHYKEAIDSYNQSIKLSSDYYNPWNGRGNALRELGHYKEAIDSYNQSIAFKPDYYNPWNGRGNALYDLGHYKEAIDSYNQSIAFKPDYYNPWNGRGNALYDLGHYKEAIDSYNQSIAFKPDYCDPWNGLGNALRELGRYKEAIDSYNQSIKLEPNYCQPWTGRGNVLYDLGQYRESISSYERSIALKPDYCNPWNGRGNALRELGLYQEAMRSYKQAIALKSDYYYSWNGRGNVFYSLKDYGEAITCYDQAIAYSQGQFWQAWDNRGLAILELQGDDKLALTVWDEGIQAILPDSSAYPYGIAMLHRRKAKTLYNSSQNQPSPFQNWLRARENYQKAIDLLPLLDYPKLHLELWQDFLKICQQLGDQRTIQAALQEASAKLQRLLDDPDRSLGEKISLERRFESFKQIQIDSLAQQDPIAAIELAETCKNRCLWRLREDWKASTPNTSYTEIQSLLNETTAAIYWHRSPAAITTFILHHNQPPKILPLTSPKTSSLKPGQQPYPAAAHQLAQFEAWLQQWTALYQNYNYENGKTDPWRQNMELLLFNKLRKILEINSLCKELQPIQTLILIPHRDLHLLPLQSLFPGKFRCTMLPSARLALDHLPTSPLPHSPTLTSIEDPPTHYTKRQSKTPKKMLYAELESTLISTFFSTHSLTSDQATRTALQIHLTQPADFFHFTGHAYHNFDDPLDSALALAGTELLTLRDIFQLNLNPYRLVCLSACETGLTRQRDLTDEYVGLVAGFLKAGVNFVISTLWIVDEISSALFMIRLYENLRRSLSPIDAFREAQTWLKSDYATLIPWYNALSDRLPNHSGHAETLKDAAHLALKDAAIKGMSHRPFEHPYHWAGFMLTGYEVTSP
>NZ_AP018203.1|WP_017289539.1|4994384_4995599_-|hypothetical-protein
MAHLIYPHLCLFSYVLRDETQDSDERESFQKDLIAGTVYRYGRGDTEQYLITSAIEKQESQSLDNLKLLKEIVLAKTGSCDRELGRSWLVFGVLPEGEDPQNIVRSSCEILGIENLSDSADQWQGAKIFECGLENQHGIVALYSSLDEMKAIAGEALQEWLYLLQFRHKVNWAYGNTRQIKPLLSQHLFPKPSSIMSLTMQDVEVSELDLQNLTQDLKQNLTLLSQYTECLSFLEFQLETVKTNLENYRSRLSSMSAKGSHSFQKLSQFEQIGSRDVRQIERDIATLTIGLRVREKTTDTIRGLVELEQAERDRRLEAQSQKFQDSIAVLGVGVGSVAITASFAAAKLEDASIVQSVVKVVPAPMRVSPWTEGAIGVLMCSAIGILFAVLIRVWLFFGKGRKSR
>NZ_AP018203.1|WP_017289540.1|4995599_4996064_-|hypothetical-protein
MLDIYSKLFPMQETDARSLRAALAAIAESPNALDPEMIQTLNQVAIELKDQPASAIAKLRQVMKASALKSLYEEARQELLAGYQSQPRGKEIQIPPNQSPKPGENEIENLSVPLDRIAAAQEILAAKNPSERAQEERAKIANNGKFWEWVIYLI
>NZ_AP018203.1|WP_017289541.1|4996370_5000591_+|AAA-family-ATPase
MYSASPLSIRVTEVGEYIRYRSCERRFKLEYNDRDLASELPFADRLFNTIDPVLQAAGRQREDAWEVSLQSGGLTDLTNFSTQSGSETTTRSGNDTNWHDFATILSGISIGSNSYGREISIHARLGAFEIKGQLDFLVVLWDGSRPRLKIVECKASRRDRTYHRIQVTLYRMMLSALLESHPLFIGGYRITSEDIECVVARIQEDNNLSQDILALAPLNLETEEADIRRLIAPGGSLERIVNSDLADLDYQIESKCDDCVFSVHCLTESARERRLELLGLEPSVIRSLRNAGINSIDDLAELDLAGGQAITLRQDPSYSGNLELMRLHAQARRKTLPGGDTHPDEYEVISLPNTGQGQLPQHETSDGRRLIRIYLSIDYDYVENRIGALAAHVTNSNWQLHTGWLDGDPDPETGLVRRVPNHVIQEQNRQNEIGRDGNNRPIYEERPLLSRDVIHFKNDPWTGDYVTDTSAERTLIQSFLSELVDAIADVAELDEAPIHYYIWSRSDMAQLVEGCSRASSRLLASLRELLGCRDHLEQLIYSCLQEEVDQRFALGWTSRGLSVAASLKWFGNTYHWQRRVSGRPISLHQEFTQDIFDFKTDLWIDPSVPAWTEEGDGIRHKFEIRSRFHDSLTAPYWRAFWRSLPNPSAIRDARVRRAINSYNNAQRPNNLREYLRARVHALRWIEERIRFKNPEISKPNVIIANLPDFNLGVNDTARAALDFLKLDQHINLTSWIAEHLVPPLYRISTGKTIPLRNIVSLGQVDDSCQLTANLDLTDFDINLEAFRNNCNLGPGAFVRLSPFSEARRGQTFRQLMIGGITCTLQNLDWDSGEVSLSVVRFRGSDLYRLGSRVPERGPLFDRATLDESPSDFVAPRVDNRLQTVINSHVYQWFHPELSQIPAQIDIAPAMIEQYQEILRTLRLRRGRQLAQEQREAATEGLRTRIQLLQGPPGTGKTETTAASTLLRILARRTVRTEGKNQYGEIVVIAAHTHTAVNNLLQRIHSVLPHFIDAASESGLRMPPVRLAKVVSRDEDEVPGGDIPNIPSEPSLKVFQPFRENSVLIIGGTTGAILKLAKKLEGFSSFKGFPISTLIVDEASMMVFPHFLALTTLVGTDGEIMLTGDHRQLSPIVAHDWENEDRPPVVAYQPYVSAYQAVLNIKQNLGVPDSQILCSALSFTFRLPPLIRELVARLYVRDGIHLTGPERNSSPGIVPVTAWEKLWSASTGLYLVLHSERRSRKNNETEVAIVEQILEANYAAIPENSVAIVTPHRAQKALLNSGLTNYRNIVDVVDTVERLQGGERPTVIVSATASDPSAISKNVEFILDLNRSNVAFSRAQERLIVVCSSSLLDHIPADLEHYESAMLWKSLREICSQEVACETVNGHTVQIFTPPDALPEAIVEEEL
>NZ_AP018203.1|WP_017289542.1|5000585_5001995_-|DNA-(cytosine-5-)-methyltransferase
MRLSFVDICAGLGGFHKALSSFGFECVFASEINEELRENYKKNFPSVAHLTYGDIREAKNLVPKHDILCAGFPCQPFSKSGHQRGFNDPTEGTIFHEILEILEKCRPKYLFLENVGNFERHDSGRTWSIVKTRLERIGYSVRGTTHVGSGGPGLFSPHHLGFPHCRERFFIVGVLNEELPENPFPAKNIQPLIPLEKYIKLNKNLSQQERKETSLSDQQRECINHWNQLIKNLPEKTVSLPSFPIWGDEFEATYPFESYTPYAATIRELRACLNAYSLKKRMSKDELLALLPSYAQTPESHFPNWKVRFIRQNREWFHKYSRFFTREWLDDLSQFPPSLRKLEWNCQGEERNLWQHILQFRPSGLRVKRYSSIPSLVAMTETQIPILGPKKRFLSRSEGLLLLGLPEEHILPETRERAFKALGNGVHVEVVKAIVESVLSYTAFSINRGKQSKNLILNLGGDQDIEIAS

Crispr_ID: NZ_AP018203_14

• CRISPR_ID: NZ_AP018203_14
• CRISPR_location: 6058967-6059067
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_14

Consensus_repeat	Method
ATTCAACATCAATTCGGCAAGTTCTCTCGCTTC	CRISPRCasFinder

spacers of NZ_AP018203_14

>14.1|6059000|35|NZ_AP018203|CRISPRCasFinder
TGGGGAAGTTCTGCCGTGGCATGTAGATGGGTGTA

CRISPR arrays and Neighbor proteins around NZ_AP018203_14

CRISPR arrays

The CRISPR arrays of NZ_AP018203_14

>merge|NZ_AP018203|14|6058967-6059067|CRISPRCasFinder
ATTCAACATCAATTCGGCAAGTTCTCTCGCTTCTGGGGAAGTTCTGCCGTGGCATGTAGATGGGTGTAATTCAACATCAATTCGGCAAGTTCTCTCGCTTC

>NZ_AP018203|14|12|6058967-6059067|CRISPRCasFinder
ATTCAACATCAATTCGGCAAGTTCTCTCGCTTC	TGGGGAAGTTCTGCCGTGGCATGTAGATGGGTGTA
ATTCAACATCAATTCGGCAAGTTCTCTCGCTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017290587.1|6052785_6053025_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290595.1|6062652_6065544_-|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl|CDD|223716
NZ_AP018203.1|WP_017290591.1|6056187_6057246_-|hypothetical-protein	unknown	unknown	gnl|CDD|235316
NZ_AP018203.1|WP_017290586.1|6051673_6052723_-|radical-SAM-protein	unknown	unknown	gnl|CDD|213890
NZ_AP018203.1|WP_017290597.1|6068408_6068918_-|chemotaxis-protein-CheW	unknown	unknown	gnl|CDD|366716
NZ_AP018203.1|WP_017290594.1|6059493_6062487_+|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143442
NZ_AP018203.1|WP_017290603.1|6076751_6077108_+|HetP-family-heterocyst-commitment-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290590.1|6055305_6056088_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213228
NZ_AP018203.1|WP_017290602.1|6075179_6076712_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|130902
NZ_AP018203.1|WP_017290589.1|6054143_6055298_-|MCE-family-protein	unknown	unknown	gnl|CDD|178642
NZ_AP018203.1|WP_017290592.1|6057577_6058048_-|DUF4385-domain-containing-protein	unknown	unknown	gnl|CDD|373016
NZ_AP018203.1|WP_017290585.1|6051102_6051630_-|LapA-family-protein	unknown	unknown	gnl|CDD|377648
NZ_AP018203.1|WP_017290593.1|6058290_6058956_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187586
NZ_AP018203.1|WP_017290599.1|6069333_6070404_-|response-regulator	unknown	unknown	gnl|CDD|381129
NZ_AP018203.1|WP_017290596.1|6065543_6068336_-|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|214599
NZ_AP018203.1|WP_017290601.1|6071861_6074816_+|peptidase-domain-containing-ABC-transporter	unknown	unknown	gnl|CDD|225183
NZ_AP018203.1|WP_017290588.1|6053766_6054147_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|367559
NZ_AP018203.1|WP_017290598.1|6068923_6069301_-|response-regulator	unknown	unknown	gnl|CDD|381093
NZ_AP018203.1|WP_017290600.1|6071347_6071593_+|photosystem-I-reaction-center-subunit-PsaK	unknown	unknown	gnl|CDD|183899
NZ_AP018203.1|WP_017290584.1|6050511_6051102_-|shikimate-kinase	unknown	unknown	gnl|CDD|234654

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017290600.1|6071347_6071593_+|photosystem-I-reaction-center-subunit-PsaK	gnl|CDD|183899	PRK13214, PRK13214, photosystem I reaction center subunit X; Reviewed.	1.91294e-31
NZ_AP018203.1|WP_017290595.1|6062652_6065544_-|hybrid-sensor-histidine-kinase/response-regulator	gnl|CDD|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	3.13286e-159
NZ_AP018203.1|WP_017290591.1|6056187_6057246_-|hypothetical-protein	gnl|CDD|235316	PRK04863, mukB, chromosome partition protein MukB.	0.00167459
NZ_AP018203.1|WP_017290586.1|6051673_6052723_-|radical-SAM-protein	gnl|CDD|213890	TIGR04070, photo_TT_lyase, spore photoproduct lyase. DNA damage to bacterial spores from ultraviolet light accumulates in the form of 5-thyminyl-5,6-dihydrothymine, spore photoproduct. The damage is repaired by spore photoproduct lyase, a member of the radical SAM family of enzymes. The score of this model is set to restrict itself to spore-forming members of the Firmicutes, but additional homologs scoring below the trusted cutoff tend to occur in radioresistant organisms (e.g. Kineococcus radiotolerans) and may be functionally equivalent. A related family in the Mycobacterium lineage is described by family TIGR03886, and may or may not be equivalent in function. [DNA metabolism, DNA replication, recombination, and repair, Cellular processes, Sporulation and germination].	1.16559e-118
NZ_AP018203.1|WP_017290597.1|6068408_6068918_-|chemotaxis-protein-CheW	gnl|CDD|366716	pfam01584, CheW, CheW-like domain. CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA binds to CheW, suggesting that these domains can interact with each other.	3.77351e-20
NZ_AP018203.1|WP_017290594.1|6059493_6062487_+|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl|CDD|143442	cd07124, ALDH_PutA-P5CDH-RocA, Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), RocA: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. The proline catabolic enzymes, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). In this CD, monofunctional enzyme sequences such as seen in the Bacillus subtilis RocA P5CDH are also present. These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis.	0
NZ_AP018203.1|WP_017290590.1|6055305_6056088_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	3.25866e-119
NZ_AP018203.1|WP_017290602.1|6075179_6076712_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl|CDD|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	8.05904e-52
NZ_AP018203.1|WP_017290589.1|6054143_6055298_-|MCE-family-protein	gnl|CDD|178642	PLN03094, PLN03094, Substrate binding subunit of ER-derived-lipid transporter; Provisional.	2.2936e-41
NZ_AP018203.1|WP_017290592.1|6057577_6058048_-|DUF4385-domain-containing-protein	gnl|CDD|373016	pfam14328, DUF4385, Domain of unknown function (DUF4385). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 149 and 163 amino acids in length.	4.33063e-90
NZ_AP018203.1|WP_017290585.1|6051102_6051630_-|LapA-family-protein	gnl|CDD|377648	pfam06305, LapA_dom, Lipopolysaccharide assembly protein A domain. This family includes a domain found in lipopolysaccharide assembly protein A (LapA). LapA functions along with LapB in the assembly of lipopolysaccharide (LPS). Domains in this family are also found in some uncharacterized bacterial proteins.	0.000105553
NZ_AP018203.1|WP_017290593.1|6058290_6058956_+|SDR-family-oxidoreductase	gnl|CDD|187586	cd05325, carb_red_sniffer_like_SDR_c, carbonyl reductase sniffer-like, classical (c) SDRs. Sniffer is an NADPH-dependent carbonyl reductase of the classical SDR family. Studies in Drosophila melanogaster implicate Sniffer in the prevention of neurodegeneration due to aging and oxidative-stress. This subgroup also includes Rhodococcus sp. AD45 IsoH, which is an NAD-dependent 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase involved in isoprene metabolism, Aspergillus nidulans StcE encoded by a gene which is part of a proposed sterigmatocystin biosynthesis gene cluster, Bacillus circulans SANK 72073 BtrF encoded by a gene found in the butirosin biosynthesis gene cluster, and Aspergillus parasiticus nor-1 involved in the biosynthesis of aflatoxins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.58796e-81
NZ_AP018203.1|WP_017290599.1|6069333_6070404_-|response-regulator	gnl|CDD|381129	cd17602, REC_PatA-like, phosphoacceptor receiver (REC) domain of PatA and similar domains. Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.	2.93635e-40
NZ_AP018203.1|WP_017290596.1|6065543_6068336_-|GAF-domain-containing-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.11864e-61
NZ_AP018203.1|WP_017290588.1|6053766_6054147_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	3.13576e-13
NZ_AP018203.1|WP_017290598.1|6068923_6069301_-|response-regulator	gnl|CDD|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.6865e-36
NZ_AP018203.1|WP_017290601.1|6071861_6074816_+|peptidase-domain-containing-ABC-transporter	gnl|CDD|225183	COG2274, SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms].	0
NZ_AP018203.1|WP_017290584.1|6050511_6051102_-|shikimate-kinase	gnl|CDD|234654	PRK00131, aroK, shikimate kinase; Reviewed.	1.27585e-70

Protein sequences

>NZ_AP018203.1|WP_017290593.1|6058290_6058956_+|SDR-family-oxidoreductase
MATYLVTGANRGIGYEYCRQLQAQGHEVIAVCRTASEELRQLGIRVEEGIELTSESAIAELRSRLGEMTIDVLINNAAIAKRIDLSHLDVASIREQFEVNAIAPLRLTHALLPLLKSGSKIALMTSRMGSISDNTSGGSYGYRMSKVALSMAGKSLAHDLKPQGIAVAILHPGLVQTRMTNFTVNGITPETSVKGLLQRIEQLSLDNTGTFWHSNGEVLPW
>NZ_AP018203.1|WP_017290592.1|6057577_6058048_-|DUF4385-domain-containing-protein
MQEFDYSLDFKAIDFRQHPELYRMGRGEQGVLLVEPYKSEILPHWRFKTPEIARQSADAIYQLFLNYKAQQDFVGMDMARKFLQMGYTRARRYANHKSGRKYDKDAQVVLPRVEDPVKAESAQIFYEKWQLAKTDSLYIELRDRHRKQSAEAQVLD
>NZ_AP018203.1|WP_017290591.1|6056187_6057246_-|hypothetical-protein
MQSFLSIDDLEAASQETLVLMDTRREIQQRLEQYCNRLEDLKRGFDEKGILEGDTQARNTYEQLVIAIRHYRSQIQNDLPELSRRLIEARQSLEENGENTTDIDFIKQVIEERREEQAQREYEAQMSRHQAEKLTQERHETAEQLLDRIREQTSYYDASYLAMDVYHYREDLKGVDRLDEVVEFLFNRVQELSDKPITLQGTAIQKLKIMDAHARKLWAQAQSEPKAILEKKPKPETDIEEKEQKESYTHLRGKVVVFGGHTTTRTYVKEKLPKVYFVWSTVEDGLLIVDQAVQQIQTADAVLLLTDDTSHAVTRKAMTELRRLKKQPIELHHEGVNTIVEKIAWKLMFKSC
>NZ_AP018203.1|WP_017290590.1|6055305_6056088_-|ABC-transporter-ATP-binding-protein
MADPLIELKGVSKRFGDNAVLDQVDLTVYRGEALAIIGPSGTGKSTVLRIMAGLLAPDSGEVYIGGKRRKGLIEDAADPLHISMVFQQAALFDSLNVEENVGFLLYQHSRLPRQRIRQLVEERLEMVGLSGISQRFPAELSGGMRKRVSFARAIMANPDNPNDTPDVLLYDEPTAGLDPIASTVIEDLVRSLQCPKRGCQSYVMVTHQESTIRRTADRVLFLHRGQVQWEGKVHEIDTTDEPLIRQFFSGSVEGPIQVLG
>NZ_AP018203.1|WP_017290589.1|6054143_6055298_-|MCE-family-protein
MRSRTVREGSVGLMILAGVGLFGGLVLWLKGLNPANRSFTVVAEFETINGVQVGSPVRYRGVNVGRISNIAAGANGVEVKLEIAPADLVIPRDSTLSVNQTGLLGETVLDISPLKDLVATAEPGKPLDRDCNRDLILCENSRIQGVMGISTDELIRATIKFADVYSNPQFTGNINALTKNSSVAAAEIAQLSREVTGLVKSARQEVGTFSATARSISNTADRATLTITQINDLIAANRSTLVSTLDNLSATSSELRTSVVRLSPILNRVESSQLINNLETLSANAVQTSANLRDISVTLNNPANITMLQQTLDSARATFENTQKITSDLDELTGDPQLRDNLKRLINGLSGLVSSTQQLQQQADIAQILAAPKPIAYPTPTPSP
>NZ_AP018203.1|WP_017290588.1|6053766_6054147_+|helix-turn-helix-transcriptional-regulator
MDAQRPFTLQDIYRFFQTPQVIFLNQQLTVCYLLSILVESDSYGTEFVQSLKQNYPGYRLSDTILQSSLRFLEKEGLVSSYWKKPEKRGRPRRMYQLSSSARPQAEELSTLWREYVLNHPIETGDS
>NZ_AP018203.1|WP_017290587.1|6052785_6053025_-|hypothetical-protein
MSIVVDLEMSDTEYLELLTQGRNPVCEQIYTQQLSSYGFSLIEAKQLAPLFEKADCSIAEKIAVNCALKQVWNHLIKLA
>NZ_AP018203.1|WP_017290586.1|6051673_6052723_-|radical-SAM-protein
MVASPVLARESKLWMPDRVLFTPAALDEPWGQQILERVQSLDLPIEELPKNRLTGLRGEDDRETYSIAKRTLAIVTAPQSQLKLSPIPPSADWQFHLAEGCPAHCQYCYLAGSLSGPPVIRVYANLPQILDNLARYEHPNRETSYEVSCYTDPLGIEHLTGSLAECIRYFGTRQDGYLRWVSKFSHVEGLLDLPHNGHTRCRVSVNAAPVSQRLEGGTASVEERLQALRRLGLEGGYPLGIVIAPIMPIDDWQAHYTQLLDRMSELIDFDCDLTFELISHRFTPGSKQVLLSWYPNTKLDLDESARVVKRNKFGGMKYVYDAKTMRELRQFFERELARRFPHGKILYWT
>NZ_AP018203.1|WP_017290585.1|6051102_6051630_-|LapA-family-protein
MALLRFVFILAVAGILVIFTLSNSTVPMSIVFLGVRSPTMPLSLWILGAIALGIATTIIINFLFGLTRFAARRSERKTVRQSTKPAGVYTYGQQSPPSKSEDADDWFSDGSDDWGETPRNRPRQEFEKRQEPTTETRSGSSYSYTYREPTTPPDVVDADYKVIKPPTRNLDEEEF
>NZ_AP018203.1|WP_017290584.1|6050511_6051102_-|shikimate-kinase
MLNGVSVFLIGMMGVGKTTIGQLLAQRLNYEFLDTDMFIEQATGQSVSTIFAESGESIFRQLETATLSQVSSRLRKVVATGGGIVVAPDNWSYLKHGVIVWLDLPVEQIQKRLSDDTTRPLLQQQDLGSRLNQLLSERRSRYAQADIHILIQPDETPDQITERVLRAIAQECDRKRQMDEAIQQLNKEMPFQTNAD
>NZ_AP018203.1|WP_017290594.1|6059493_6062487_+|L-glutamate-gamma-semialdehyde-dehydrogenase
MVSQAFGDALGTGSREHYESQTQAIARQLLRATRESRSWFAQVRDQMQWDDKLLGWAMSNPGLRVQLFRLIDCLPALRSKPEIARHLQEYMSDQTVELPAALKGLLNFANADSMPGQLAATTLSTAVETLAHKYISGENLKQVLKTIERLRKEKMAFTVDLLGEAVITEAEAQSYLDRYLELLEQLTEASKSWSKVEQIDFADGQPLPKVQVSVKLTAFYSQFDPLDEAGSQVRVADRARTLLRRAKELGAAVHFDMEQYAYKDLTLETLKALLLEEEFRSRSDVGMTIQGYLRDSQADLQGLIDWAKERGTPITVRLVKGAYWDQETIKAVQKDWQQPVFNDKAETDANYERLTELLLENHEVLNAAIGSHNVRSQAHALAIATALEIPKSRIEFQTLYGMGDKLAKAIVEQGYRVRVYCPYGELIPGMSYLIRRLLENTANSSFLRQNLEERPIEDLIAAPQVGEPSQLKALDKFENAADTDYADRAKRDRIQSALKSVRQQFGQTYLPLINGEFVETAEKLKSENPSRFSETVGTIGLISVDQAEDAIASAKAAFPAWKRTSAQERAHILRKAANLFEQRREELIAWMTYEVGKPVKEGDGEVSEAIDFCNYYADEMERLDRGVDYDFPGETNHYRYHARGIVLVISPWNFPLAIPVGMTVAALVTGNCALLKPAETSSVIAAKIAEILVEAGIPAGVFQFIPGKGHTVGAHLVKHPDVHMIVFTGSQAVGCQIYKDAAVLQPGQKHLKRVVAEMGGKNAVIIDESADLDQAVQGVVQSAFGYSGQKCSACSKAIVLEPVYETFLSRLVEATRSLNIGEAELPGTKVGPVIDKEAQNRIQKFIEWGERAGTLVLKMPVPEGGYFVGPTIITDVSADAKIVQEEIFGPVLAVMRASSFQEALDLANGTPYALTGGLYSRTPSHIEQAQADFEVGNLYINRGITGAIVARQPFGGFKLSGVGSKAGGVDYLLQFLEPRVVTENVQRQGFAPIEGAE
>NZ_AP018203.1|WP_017290595.1|6062652_6065544_-|hybrid-sensor-histidine-kinase/response-regulator
MAQDKELEIRRQFLDEAQEYLDVLDATILDLANHPIDVAKANAALRAAHSIKGGAGMMGFQVLSELAHRLEDSWKVLKIDKSIVVSPRLENLLLASVGCLRQVVEFDRESMQRHQDSFVDANWLSVEAYPVFDALHAELGDPQEENAASILSPEEGQDIVPLLFETEVEGCLERLETVLNTPDQPCLREEVAILAQELGGLGEMLQLSQFVQLCQSIAYAIEQDSQNTSAIAESALTAWRTAQKLAIAGQYDQIPTAIAESTLPPDLADFADVPSVLEPNVGETDWFTEALAAEALAVDDFQPIPMPTRIPVGEPKGTDFKILDPEPDISTATEAQDTTVRVPVRQLNQLNDSFGELTIDRNGLDLYLKRLRGLARTLHDRVQVLDQVNAKLRTAYDRVTLDGSRSLQDNRRSGFDALELDRYGDLHLLSQQVMETIVQLQEVSEDIDLSLDDADQSARNLTKTAKQLQSGLTQLRMRPISDVINRFPRAIREWSLQYGKEVQLSVVGGSTLIDRNLLEALNDPLMHLIRNAFDHGIEEPTLRALRGKPPQGTIEIQAANQGNRTIITVRDDGEGIPIDKIRDRAEQMGLDPVLLDAARDEELLSLIFEPGFSTSTQVTALSGRGVGMDVVRNNLKQIRGEISVNTQAGQGTTFTLSIPFALSTIKVLLIECHGMLLALPTDVVSELFLLQPNQIIETAGSEVLNWQDKVVQLVRLQKWMRFNCPQIPHGFETPPTIAMTSVVIIDQAPQWFGIQIDRCWGEQEATMRKVEGNLALPTGFSGCTILGDGRVVPLVNVTELLRWITSCERSDIQPDQAFSKQLRASLVASQPSMARSTTPTILVVDDSINVRRFLALTLERSGYRVEQAKDGQDAIERLEAGLSVQAVICDIEMPRLDGYGFLAKLRSDEQLAQIPVMMLTSRSGEKHRKVAENLGAAAYFSKPYNEQVLLRTLEGMVKSTALV
>NZ_AP018203.1|WP_017290596.1|6065543_6068336_-|GAF-domain-containing-protein
MVDQLNAAQRDQLAQSNTLKPSSIDMPPTPVKRRSLSIPGLARFRRLSLKNKATLIAITIGTLPVLVIGTIAYSFANQSITRQIVDTEETLATTLSQRIASYMSERTADLQILASLPMLTTPGLQDGTSTEEKRILFERAIENGNYESITLFDNDGNALIQTDREPIPRQDDQDYFRAALQSSRVSISRPMRLSPNTAYTIYITAPVQESGSGKRIGILRAVVPIKSLASELQNYNKVGATFSVLDASNQIFLSSQDAKIGQAASSIYSSFSQLQSRREINSSVVTQKLNNESKPVLASFIPWTGRDRLPDLGWDVVLSIPTEIAFAPQRQLLLTFLLGTAVAVFLTGLLAAWLASRATRPIVAATNAVLELGNGRLNTRLAVKGVDEISILGRNINLMAGQLQSLVSQQTENAERSQLLNQITVKIRRSLSVDDILATSVEEIRAAFKTDRVVVYRFAPDYLSGTITAESVGSNWIKALGKVVSDPMEASLVDRYREGRVWSMEDLKQAKLSHCHCEILERLEVQANMVAPIVQNQELIGLLCAHQCSAPRSWKPEEIDFFGQLAVQIGYALDQASLLEQTEDARKSAEQLSEERQQQKEALQMQLINLLADVEGAVEGDLTVRADVTAGEIGTVADFFNSIVESLRQIVTQVKDAASQVNASLSSDEQAVRQLSDEATRQADETSRTLDSVQNMLRSIQTVSNSAQQAASVAREASSTAEAGGIAMELTVQNILGLRDTIGETAKKVKRLGESTQQISKVVSLINQIAMQTNLLAINAGIEAARADEGSQGFAVVAEEVGDLATRSATATREIEQIVATIQRETTEVVEAMEQGTTQVVEGTRLVDNAKQSLEQILEVSRRIDDLVQSISEATVTQVQTSDAVSHLMQEIVAAAGRTSASSMEVSRSLRQTVEVAQELQESVGTFKVG
>NZ_AP018203.1|WP_017290597.1|6068408_6068918_-|chemotaxis-protein-CheW
MDDSVLTLATTQKNAIAPKNLGESYLKFEVGQGTQVGLPMRHVQEVLVLQPRYLTPIPNLMPGILGLMHRRSRALWVFDLAMLLDIGRLDYSPQQYDLVILRTGSTAVAAAVNRVDGIAWAKPDDLQPVPSHVTKGLIPYSKACILQSQDVIFLLDGEAILQAPLLQSH
>NZ_AP018203.1|WP_017290598.1|6068923_6069301_-|response-regulator
MSLTLMRTVLVVEDTPSEMELLSHYLREGGYSVVGAVTAKDALTKAIELKPNVIVTDVVMPGMSGFELCRSLKKNPETQKVPIIICTSKGQDIDRLWGMRQGADVYITKPFTREELIRAVQSVGG
>NZ_AP018203.1|WP_017290599.1|6069333_6070404_-|response-regulator
MVSHRPFQRLQPLSLLAQLISRRVDGCLQIVSGSVSWLLYLDEGTLAFATNSIQPFERLDRVLDQLSDRVPSLIQFDRGQLRQFETVAGTYPAISADYQAIEWLLGQRLIDRSQAAALIELLAIDVIKPFLSVTEGIYEVIAKPNFLHYPNLCQLDLRPIVERCHSELKSHSPAIPKATSPDASIPLPSPVSSAPSARPLSFTTSQPAISQPTQTPVTAVPTGSAPTSSVAATAQVQYKIACIDDSPTVLQAISTFLNDSSVSVIMINDPVKALMQIVRSKPDIILLDVGMPNLDGYELCSLLRRHPSFKLTPIIMVTGHTGFIDRAKAKIAGASGYLTKPFTQSELVKTVFRYLE
>NZ_AP018203.1|WP_017290600.1|6071347_6071593_+|photosystem-I-reaction-center-subunit-PsaK
MLAVAPRAVDWSPSVGAVMIICNILAIAFAKYTMKNPSAPPEMPSSNMFGGFGLPAVIGATCFGHVLGAGAILGLSNIGVL
>NZ_AP018203.1|WP_017290601.1|6071861_6074816_+|peptidase-domain-containing-ABC-transporter
MKKNSEIGRDAPPVNLDSAYELLSEILMTRFSVDPAFSRSFNFRAFQLGDVLNVSHVMILCQGRVRLIRSGVPAAVLDVGDSWGSDGQFCDPVLSYQAIAASAGFVAEIDSIPSELESDLQKMAHDRQRLLFLKSETDLRSHSSHVLKKLLPHLCEIRIAAGSSVADQSGRFWLRQGQVQGTQPPTIGQGWGYPQPVPSDWVAATELQLYQMSANHWDTVFQSEASPEVKPIVQPLARVQPVEAQPVRPIPAPTKPAAIEFAKPRRSRIRIGRAPFIPQQSSSDCGAACLAMIAQYWGKRLSINMLRNLAGVGRSGASLKGLALAAESLGFQARPVRSSFNRMTEQSLPWIAHWQGEHYIVVYRMKRNRVLVADPALGRRSISYEEFQASWTGYALLLSPTQLLKALPKSKPSLGRFLGAFTPYRSIVWSILLASVLLQIFGVVTPLFTQIILDQVVVHKSLPTLQIFIFGLLLFGSWKIGLTCTRQYLLDFFSNQVDLTLISGFIAHALNLPLQFFATRHVGDIVTRVQENHKIQLFLTRQAITAWLDAVMAIVYVGLMLHYNWQLTLLVLGLIPPIIIMTVIASPFLRQMSRQIFHESAKQNSSLVEMLTGISTVKATASERELRWQWEDELTSMFNAQFRGQKLANALQGASTLINLFGSTLLLWYGARLVIADQLTIGQLVAFNMMIGSVITPILSLVGLWDEFQEVLVSIERLDDIFSAQPEESPDQPLLVLPRIRGEVTFENVTFRYHADDSRNILQNISFTARAGDTIALVGRSGSGKTTLANLLQGLYQPTSGRILIDNTDLHHVSPQSLRSQLGIVPQECFLFSGTILDNITLYRPQYRLEDVLKAAKLAEAHAFIQSLPLGYQTKVGERGTMLSGGQRQRIAIARALLNLPRILILDEATSSLDTESERRFQKNLQQISRDRTTFIIAHRLSTVRNADCILVLDKGIIAEQGTHEQLIKQGGLYTQLAQQQLDL
>NZ_AP018203.1|WP_017290602.1|6075179_6076712_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MSIRIDSLSLEDAPPPTLSSNLETDELSEFAYLYGGTLASTPVMPSAFPDPPASSADSSDPTPPERWSTALQNVLDRPPATFPSRLVAGGVIFCAACVGWATTSQMEEIGRAQGRLVPQGEAYKVHPVVSGKIAQVYVQEGQTVKAGQTIAELDHEIALNRVGALQQEERNYEKELLQIDALIDKTRLEAQTRSTIATAEIRAQEATIAQAQAKLQGQDTTILQTEERATTSQALLAQLQADADSQKERLERLKFLVDQGALAREHLYQAEQHFGDRQRSITQQTGDIQQALAESQKMRSDLQQVVAESRRLRAQLTQKYAEGQTAQIQAQQTIQNLFVQRTQLMAKKQQTEKLIQQANAEMKQLKLQAPVDGIVSALNVSKPGEVVQAGQTVSEIAPQTAPLVLVAALPTREAGFVKPGDKVQVKFDAYPYQDYGIVGGKVVKLSPDIKQDERLGAVYRVEIQLDRHMIQSTPLKAGQTASAEIIVRRRTIAEMLLDPIRQLQKGGISL
>NZ_AP018203.1|WP_017290603.1|6076751_6077108_+|HetP-family-heterocyst-commitment-protein
MTFQRGSVAQSRNKVMSPEQFKQVVDAITEGRYSWACVLILRFAGYNPVHFIPHRTYSRLLKENRVQTPSRLTQIKDLAYSETVEQPEEVLHGGKLPIWFVNSPPCEQLKAQPVYSIW

Crispr_ID: NZ_AP018203_15

• CRISPR_ID: NZ_AP018203_15
• CRISPR_location: 6234878-6234972
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP018203_15

Consensus_repeat	Method
ATGCTGCCACGAGAAGCTCCGCCTGTCGCTTG	CRISPRCasFinder

spacers of NZ_AP018203_15

>15.1|6234910|31|NZ_AP018203|CRISPRCasFinder
ACGGACAGTGCGGTTTTGCCGATTCGTAAAT

CRISPR arrays and Neighbor proteins around NZ_AP018203_15

CRISPR arrays

The CRISPR arrays of NZ_AP018203_15

>merge|NZ_AP018203|15|6234878-6234972|CRISPRCasFinder
ATGCTGCCACGAGAAGCTCCGCCTGTCGCTTGACGGACAGTGCGGTTTTGCCGATTCGTAAATATGCTGCCACGAGAAGCTCCGCCTGTCGCTTG

>NZ_AP018203|15|13|6234878-6234972|CRISPRCasFinder
ATGCTGCCACGAGAAGCTCCGCCTGTCGCTTG	ACGGACAGTGCGGTTTTGCCGATTCGTAAAT
ATGCTGCCACGAGAAGCTCCGCCTGTCGCTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018203.1|WP_017290734.1|6229502_6229931_-|hypothetical-protein	unknown	unknown	gnl|CDD|182473
NZ_AP018203.1|WP_017290741.1|6240237_6240447_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP018203.1|WP_017290730.1|6225284_6226151_+|polyphosphate-kinase-2-family-protein	unknown	unknown	gnl|CDD|274737
NZ_AP018203.1|WP_017290743.1|6240709_6241903_+|MFS-transporter	unknown	unknown	gnl|CDD|341031
NZ_AP018203.1|WP_017290728.1|6223789_6224266_+|DUF1499-domain-containing-protein	unknown	unknown	gnl|CDD|377828
NZ_AP018203.1|WP_017290735.1|6230039_6231395_-|response-regulator	unknown	unknown	gnl|CDD|381147
NZ_AP018203.1|WP_017290738.1|6235239_6237774_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|227328
NZ_AP018203.1|WP_017290732.1|6227654_6228056_-|hypothetical-protein	unknown	unknown	gnl|CDD|375088
NZ_AP018203.1|WP_017290739.1|6237914_6239438_-|AMIN-domain-containing-protein	unknown	unknown	gnl|CDD|378705
NZ_AP018203.1|WP_086370973.1|6224342_6225254_+|phosphorylase	unknown	unknown	gnl|CDD|226803
NZ_AP018203.1|WP_017290733.1|6228143_6229004_-|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-iron-sulfur-ATP-binding-protein	unknown	unknown	gnl|CDD|177011
NZ_AP018203.1|WP_017290746.1|6243907_6245233_-|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|366010
NZ_AP018203.1|WP_017290748.1|6246007_6246379_-|VOC-family-protein	unknown	unknown	gnl|CDD|225861
NZ_AP018203.1|WP_017290740.1|6239653_6240088_-|hypothetical-protein	unknown	unknown	gnl|CDD|173412
NZ_AP018203.1|WP_017290745.1|6242564_6243794_-|dihydroorotase	unknown	unknown	gnl|CDD|236002
NZ_AP018203.1|WP_017290727.1|6222837_6223749_+|homoserine-kinase	unknown	unknown	gnl|CDD|234920
NZ_AP018203.1|WP_017290744.1|6241996_6242587_+|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NZ_AP018203.1|WP_017290747.1|6245360_6245759_+|DUF3110-domain-containing-protein	unknown	unknown	gnl|CDD|371489
NZ_AP018203.1|WP_017290731.1|6226224_6227628_-|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-subunit-N	unknown	unknown	gnl|CDD|214353
NZ_AP018203.1|WP_017290736.1|6231395_6234122_-|CHASE2-domain-containing-protein	unknown	unknown	gnl|CDD|226703

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP018203.1|WP_017290734.1|6229502_6229931_-|hypothetical-protein	gnl|CDD|182473	PRK10455, PRK10455, periplasmic protein; Reviewed.	0.00319717
NZ_AP018203.1|WP_017290747.1|6245360_6245759_+|DUF3110-domain-containing-protein	gnl|CDD|371489	pfam11360, DUF3110, Protein of unknown function (DUF3110). This family of proteins has no known function.	9.15577e-41
NZ_AP018203.1|WP_017290730.1|6225284_6226151_+|polyphosphate-kinase-2-family-protein	gnl|CDD|274737	TIGR03709, PPK2_rel_1, polyphosphate:nucleotide phosphotransferase, PPK2 family. Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which. [Central intermediary metabolism, Phosphorus compounds].	2.2981e-165
NZ_AP018203.1|WP_017290743.1|6240709_6241903_+|MFS-transporter	gnl|CDD|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.000259469
NZ_AP018203.1|WP_017290728.1|6223789_6224266_+|DUF1499-domain-containing-protein	gnl|CDD|377828	pfam07386, DUF1499, Protein of unknown function (DUF1499). This family consists of several hypothetical bacterial and plant proteins of around 125 residues in length. The function of this family is unknown.	2.66404e-52
NZ_AP018203.1|WP_017290735.1|6230039_6231395_-|response-regulator	gnl|CDD|381147	cd19920, REC_PA4781-like, phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains. Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.23115e-58
NZ_AP018203.1|WP_017290738.1|6235239_6237774_-|CHAT-domain-containing-protein	gnl|CDD|227328	COG4995, COG4995, Uncharacterized protein conserved in bacteria [Function unknown].	6.35767e-143
NZ_AP018203.1|WP_017290732.1|6227654_6228056_-|hypothetical-protein	gnl|CDD|375088	pfam17265, DUF5331, Family of unknown function (DUF5331). This bacterial family of unknown function can be found in Cyanobacteria.	3.82044e-25
NZ_AP018203.1|WP_017290739.1|6237914_6239438_-|AMIN-domain-containing-protein	gnl|CDD|378705	pfam11741, AMIN, AMIN domain. This N-terminal domain of various bacterial protein families is crucial for the targetting of periplasmic or extracellular proteins to specific regions of the bacterial envelope. AMIN is derived from the N-terminal domain of AmiC, an N-acetylmuramoyl-l-alanine amidase of Escherichia coli which localizes to the septal ring during division and plays a key role in the separation of daughter cells. The AMIN domain is present in several protein families besides amidases suggesting that AMIN may represent a general targetting determinant involved in the localization of periplasmic protein complexes.	1.22538e-13
NZ_AP018203.1|WP_086370973.1|6224342_6225254_+|phosphorylase	gnl|CDD|226803	COG4360, APA2, ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism].	2.18606e-92
NZ_AP018203.1|WP_017290733.1|6228143_6229004_-|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-iron-sulfur-ATP-binding-protein	gnl|CDD|177011	CHL00072, chlL, photochlorophyllide reductase subunit L.	0
NZ_AP018203.1|WP_017290746.1|6243907_6245233_-|histidine-phosphatase-family-protein	gnl|CDD|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	6.90593e-69
NZ_AP018203.1|WP_017290748.1|6246007_6246379_-|VOC-family-protein	gnl|CDD|225861	COG3324, COG3324, Predicted enzyme related to lactoylglutathione lyase [General function prediction only].	3.46216e-36
NZ_AP018203.1|WP_017290740.1|6239653_6240088_-|hypothetical-protein	gnl|CDD|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	4.88909e-08
NZ_AP018203.1|WP_017290745.1|6242564_6243794_-|dihydroorotase	gnl|CDD|236002	PRK07369, PRK07369, dihydroorotase; Provisional.	0
NZ_AP018203.1|WP_017290727.1|6222837_6223749_+|homoserine-kinase	gnl|CDD|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	1.83202e-129
NZ_AP018203.1|WP_017290744.1|6241996_6242587_+|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	8.16752e-55
NZ_AP018203.1|WP_017290731.1|6226224_6227628_-|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-subunit-N	gnl|CDD|214353	CHL00073, chlN, photochlorophyllide reductase subunit N.	0
NZ_AP018203.1|WP_017290736.1|6231395_6234122_-|CHASE2-domain-containing-protein	gnl|CDD|226703	COG4252, COG4252, Predicted transmembrane sensor domain [Signal transduction mechanisms].	7.7066e-111

Protein sequences

>NZ_AP018203.1|WP_017290736.1|6231395_6234122_-|CHASE2-domain-containing-protein
MRQKIQAFFRRNRSVLIIAPSVAATVTAGQMLGVFNLLEWQVRDQFFRQRSTGEMAKSIVVVTIDEEDIQSVKKWPIPDWSLAQLIEKIRAQKPRAIGLDLYRDLPEGEGHKQLVNVFESTPNLIGVEKITGDRVAPPPALKKKDQVAIADLVLDGDRQVRRALLTSEDSKDQTVKPGLATRVALKYLEAEGTTLDSSDKNPLQYKLGQTVYLPLKDQEAGYSDADVGGYQILLNWHGSEKAFHTVSMRDVLAGRVPADLMRDRMVFIGSIAASTNDFFGTPFSSSWFSAQDPTPGVVVHANIAYQLVNSVKQNNMLHGLTIKKFIAWIFACSLFGTIGSWTLASLPSRQRLPGGKILWATVGTSGAIVSGAYFIFLGGMLIPVTPALASFIASVVATVNSHKHQKLEEANRELESANNQLIDYSKTLETKVEERTRELLEAKQAADSANQAKSEFLANMSHELRTPLNGILGYAQILERSVAPKEQEGIKIIHQCGSHLLTLINDILDLSKIEARKLELDSSSIHLASFLNGVAEICRIRAEQKGIGFQVEIDDCLPIGIVADEKRLRQILINLLGNAIKFTDQGQVTFRALSAQESRIRFEIEDTGVGMSTEQVDKIFLPFEQVGAVERKSEGTGLGLAISQRIANLMGSGIQVQSRLGEGSIFSLEVEFAIASEWNQSTQNLAQTQTVIGIQGQPPVILVVDDDRTQCSMVATLLQEIGFEVKVAYTGSDGWLAIDEDHPDLVITDLAMPLLDGMGLIEQLRSTAETSAIPIIVSSANVFGSNRQRSLDAGANAFLPKPFEVGELLNTLQALLNLTWIYQTQPTESPAQAAPAQGKLVLPAQNVLDDIYHLAMMGDITAIEGILSTLIEEDPCYTTFVAELKKLTATFQAGKIRQFIKSYTKAAH
>NZ_AP018203.1|WP_017290735.1|6230039_6231395_-|response-regulator
MIPISLVPVRILLVDDTPTNLKVLSEALQGQGWKTLMATDGESAIEQAEYALPDLILLDVMMPGIDGFETCQRLKANAKVQHIPIIFMTALSDSINKVRGLELGAVDYITKPFQQEEVIARVKLHLSISHLNQSLQTKIAEQAETEAQLQQLAQELEQRVRDRTAELEISLHQLKTTQLQLVQSEKMSTLGQLVAGVGHEINNPINFVSGNLKHIDDYTRDLFALIQMYQRKDSAEDIAEFIEDIDLEYVAEDLPKLIKSIHEGVHRLKDISLSLRSFARSDISSKTEFQLREGIESTIMLLKHRLKANEKHPEIQIIRQYAELPPISCYPGQLNQVFMNLIANAIDAFEEKNETRSYAEIVESPNMIWISTEIDRSNQTVLIRVKDNGLGMLPEIQSQIFEPSFTTKPVGKGTGLGLPISRQIVNEKHGGQLECRSIVGEGTEFTISLPI
>NZ_AP018203.1|WP_017290734.1|6229502_6229931_-|hypothetical-protein
MKKVAILLPGAIALMMAVSPMLAAHARPINRLAQAPKQEYANKLGLTDAQKQSMKSIREAVQKDIYTNVLNDGQRAQYDAAVQRGEKPGKMMRSLNLSDAQKTQIRDKMKAARQKINQEVLTQAQRDQIQQMRQQRRNRRGA
>NZ_AP018203.1|WP_017290733.1|6228143_6229004_-|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-iron-sulfur-ATP-binding-protein
MKLAVYGKGGIGKSTTSCNISVALAKRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQEKDYHYEDVWAEDVIYKGYGGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFDEYDVILFDVLGDVVCGGFAAPLNYADYCMIVTDNGFDALFAANRIAASVREKARTHPLRLAGLIGNRTAKRDLIEKYVDAVPMPILEVLPLIEDIRVSRVKGKTLFEMAESDPSLNYVCDYYLNIADQILANPEGVVPKDAADRDLFSLLSDFYLNPQQPKTAEEELDLMMV
>NZ_AP018203.1|WP_017290732.1|6227654_6228056_-|hypothetical-protein
MNIDQLRRSLKDRWLDYYEANRSWISRLSIWVSCEGKRRPSSSFILGVLSTEEPRLTEMLPLIVDLSNHPDRIVVALGLNFDPEQELNHKQLKAETPKYLPASSATEAPQKPRRPAEVDEACEGRNRTTPSPQ
>NZ_AP018203.1|WP_017290731.1|6226224_6227628_-|ferredoxin:protochlorophyllide-reductase-(ATP-dependent)-subunit-N
MTLADAQPQALNFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNAMGVMIFAEPRYAMAELEEGDISAQLNDYNELKRLCEQIKRDRNPSVIVFIGTCTTEIIKMDLEGLAPKLESEIGIPIVVARANGLDYAFTQGEDTVLAAMAQRCPTQAPTAEADKEERNAIQKLMNFGRKQEDVKREESEYVDHPPLVMFGSVPDPIVTQLSLELKHQGIKVSGWLPAKRYTELPVIEEGYYVSGVNPFLSRTATTLMRRRKAKLIGSPFPIGPDGTRAWVEKICSVFNIEPKGLEEREAKIWQSVEDYLQLIRGKSVFFMGDNLLEISLARFLIRCGMTCHEIGIPYMDKRYQAAELDFLVKTCQEMGVPVPTIVEKPDNYNQLQRIHELKPDLVITGMAHANPLEARGISTKWSVEFTFAQIHGFGNTRDILELVTRPLRRNGALKDLGWEKLVEEARV
>NZ_AP018203.1|WP_017290730.1|6225284_6226151_+|polyphosphate-kinase-2-family-protein
MKHDRFIVPANTKINLKDYDPAYTDGLTDKAAAQAELQQGVQRLAKYQDILYAQDSYALLILFQAMDAAGKDSTIKHVMSGVNPQGCQVYSFKSPSSEELDHDYLWRSNRALPERGRIGIFNRSYYEETLVVRVHPELLVHQKLPPEANGKEIWDKRFKQINHFEQYLVENGIVVLKFFLNVSKEQQKKRFLARINEPEKNWKFSVSDAKERQHWDQYMEAFEDVFNNTSTSYAPWYIIPADHKWFTRLAVSDIIVSTLKSLHLSYPTVSEVRRAELLEAKKVLESEE
>NZ_AP018203.1|WP_086370973.1|6224342_6225254_+|phosphorylase
MNELLHLPLLEHPGTLWQRTIEQTQHALSCGALLSIPTSHEFVEQAGVQFLVRIVSNLIRKEAADLKQKQEEKSGHPINPFLPYERDLFVMDISETHVCLLNKFNVVDNHLLIVTRAFEEQEALLTLHDFTAMWACLSEVDGLAFYNAGKAAGASQRHKHLQLVPFPMEKEIDRVPIDPLIKKVRSRDRITQIPEFSFLHAFARFEPETTPEDILQHYYELLETVGIRSNRVMQSAPYNLLATREWMLIVPRSQPGFGGIGVNSLAFAGALLVQTPEQLETLKQLRPLNFLKNVAVMSSIKTG
>NZ_AP018203.1|WP_017290728.1|6223789_6224266_+|DUF1499-domain-containing-protein
MRRTFTLILLLSFCWLTSISPAQASLFSFSGSRPTNLGLHNDRLTECPSTPNCVNSFSSDSTHAIAPLKSSNIEKAFADLKQVIESQPRTKIIESTENYLYAEFTSKLMGFVDDVEFYLDKTSKAIQVRSASRLGESDLGVNRQRIESIRTQLSENVT
>NZ_AP018203.1|WP_017290727.1|6222837_6223749_+|homoserine-kinase
MSITVRVPATTANLGAGFDCLGAALTLYNEFQFSPIDSGLKITATGAEADRVALDSSNMVYQTVVKFFDRVQQSVPAIAIDIKMDVPLARGLGSSATAIVGGLVGANAIAGSPMSQSEIAAFATEIEGHPDNVVPALIGGCRLAASGIDRAWEICDIPWDASIVPIVAIPNFELSTAEARGVLPTEYSRADAIFNTAHLGLFVRGVETGNADWLKAALQDRIHQPYREKLIKGYDAVREAAIAAGAYGVVISGAGSTVLALAHQQCSDSVRFAMEKAWTGLGVGVDAKCLAIDTQGTRIINTL
>NZ_AP018203.1|WP_017290738.1|6235239_6237774_-|CHAT-domain-containing-protein
MSRSKHRRLLHLCLGVLSLSLAIAITPAQATLQPTPAPIVAAQPATLLDQGRTLYQSGRFAEAVSVWQTAAQQSQAKGDRSNAALSLSYLSLAQQELGQWAEATQSIEQSLSHLKATKPQADAILWAQVLNTQASLLLHTGKAEAALETWKQAQTYYTQAGDTIGSLGSQINQSQALQSLGYYRRAKQQLNEINQQLAKLPDSQVKVSGLRTLGATLQMIGDSTESRKVLEQSLAIAKAKNLKSEISAILAGLGKAATDLNDPDAALAYLEQSEQAAVSPIEKLQARLDRFKLLIDYGLLDQAAPIAPQLLSQLEQLPPNRTSMYGAINFAASLNQLENSEKLLSLNTLSSLLEKTVQSAKSLQDSQAEAYALNQWGKLYGRTEQWAEAETVTQQSLEIARQLQADEIIAQSAWQMGRLKIEQGKTKQAISPYTEAVKSLRAIRGDLAAINPDVQFSFRESVEPVYREFVALLLEGQPGQAELTQARELIESLQVAELDNFFREACLDKTQQIDQVDTTATVVYPIILPDRLAVISSTAGKPLQYHITPISQAEVEETLDQLLAALNPVSNLQARDRVSQQVYDWLIRPIESELKQTKTLVFVLDGKLRNIPMSALYDGKQYLIEKYAVTLSPGLQLMAARSLQQTNIGAIVAGISESRSGFSALPAVETEVKKIAQTVPSSKLLNAQFTGNALSTQLKDSKANVVHLATHGQFSSRLEDTFLLTWDGVVNIKELSELLQSRDASKAIDLLVLSACDTASGDDRAVLGLAGLAVKSGARSTLATLWPVKDKAAATLMTQFYQELGQSRSTKAEALRQAQLHLIRKTDFKDPFFWSGFVMVGNWQ
>NZ_AP018203.1|WP_017290739.1|6237914_6239438_-|AMIN-domain-containing-protein
MLKKALTFSELISAIVLLTSVSAIAAPLENLRFDPDINQLEVTLAAGIKPTYSLLSKPDRIVLDLPNTQVGQISPQQTFMGAVRQVRVFQFQPDTTRIVLELAPNQTLATQQVQLQQAPSSDKIWILRPTLAARTPSPQTQAVFNSLRPIQTAPLPKTTPIQPAEPKVAQTSATPANDFGLPPAPPAINPDLPPVTPPPATNSAPPAATVPDLPPAQSTPLPPAAGSGNAPTGSSLLFPDAPITPRAVPQSPGLQLPEVNPSLAIPDSFPPINAPTNLPSTPPTVTVPQLDRRSPDPSSIVEPRSTSAPVEDTPVPVRQRTIQFGQPLPTLINQQPPSTPQQISRFANGSSESLLPVGTKLSLFYPGNEPLKLQGNQSRQDVLILQNEIRDRAGRLLVAPGSAVMGKFETDRNGSRFVTIQGQNLAFIGKSDTISGNPQVQDHRLIQNSGLGAIAGAVLGGFSGGNVIGGAALGAGVTYLTASRPATIQPRQLIQIQLTQDFNLFSR
>NZ_AP018203.1|WP_017290740.1|6239653_6240088_-|hypothetical-protein
MMMRLKAISVFAGLALMMGLTACAETEQAAPPAAPTAPAAKPAGTVNKAGESVKKTGDAAKKAGESVKAKAGEAATKAGEAATKAGEAATKAGEAAKTMTGEGVKQAGEAAKQAGEAAKQAGVAAKQAGDAAKEKITQPAEKKQ
>NZ_AP018203.1|WP_017290741.1|6240237_6240447_-|hypothetical-protein
MQTHFRLICSISTVPGWSVENDAVLISEGLFAIALPLGVCVAIFVQKKRKRRALKQQIEMLEKLWRNKV
>NZ_AP018203.1|WP_017290743.1|6240709_6241903_+|MFS-transporter
MGEDAKSGLVPNPQPSRFQAWQQVIGLAILLAAVMFTWMIYGVFQPRILSSLGFTALASQLGIYQGLLGAIVEPVVGWKSDQIFRRLNTRFPMVTFGVTLAGLICVSVSVLWQEKAVMLAIRNFVPILTTVWVIAMIIFRGPAIALLRQFTPADFPLANAILTLVFALMGAMSPLVGRLITQWGASATFLLGALSLVVGGLLFKWSQPPLQLAEVTNDPPIPLKKAIAIFWVGLAAGIQSTLLFGYSPQLLHQQIQWLEPAYLTSAILVISAVSALPLEQFALTWGVHRSMLMSFSVIALLLGVLNAPANWLFLVLFGLAFGLLFISQIPYALGAVPSNQAGFGTGLYFGGIGGGSAIVSWALGSQPVSSSIILWGFLATVIGGIGLIGTRRDRNLL
>NZ_AP018203.1|WP_017290744.1|6241996_6242587_+|signal-peptidase-I
MNRVDNPAPNNKVRQKDENPWLEGLKTIGLSAVLAIGIRQFVAEARYIPSGSMLPTLQINDRLIIDKISYRFNNPQRGDIVVFAPTPALEKQNFHDAFIKRVIGLPGDKVQVKGNRVYVNDQPLRENYIGKDEAPQYEWGPQVIPPDSYLVLGDNRNNSYDSHYWGFVPRDKIIGRAVVRFWPPNRAGEITPEPQY
>NZ_AP018203.1|WP_017290745.1|6242564_6243794_-|dihydroorotase
MFVLLQQVRSLDPVANVDRITDVLIEDGIIRAFAPSEIPPDTQIQPCAGKILAPGLIDLYSHSGEPGFEERETLTSIEQAAIAGGFTQLNLLPDTHPAIDNPASVTQIRTKFPKVNCWGALTLGTEGQQLTELAELAAAGIIGFTDGKALPNLTLIRRALEYLHPIQKPVALWACDPGLAGKGVIRQGANSMRFGLPGVPTMAESAPLSALLECVAEIGTPVHLMRISTARGVELIRDAKSRGVPVTASTTWLHLLLDTDAVGTYDPNLRLDPPLGNKHDRDALIQAVQDGIIDAIAVDHSPYTYEEKTVAFGEAPPGVIGLELALPLLWSNLVESGRWSALTLWQSLTTRSAQCLNQSFQSKDLILFAPNEKWTVDHSNLRSLSTNTSWLNHSITGRVLEIFNTEALA
>NZ_AP018203.1|WP_017290746.1|6243907_6245233_-|histidine-phosphatase-family-protein
MTTRVILVRHGESSYNVEKRAQGHCDLSTLTEKGEIMATQVAKALKDLQFDAIYTSPLQRAKRTAEVIFEGLDNPPALQVTDYLKEINVFLWEGMLFSEVQEKYPEMYDYWHTEPHKVRMTLPDGSELAPVQDLYEQAERFWRSTIPHHANQTLLIVAHSGINRALINTAIGLEPADYQRFHISNCGITVLNFSGDFGQTVQIESLNVTSHLGETIPKLRPKHKGARLLLVRHGETEWNRQGRFQGQIDVPLNDNGRVQASQAGEFLKSVSIDSAVSSSMARPKETAELILKHHPDIDLKLRDDLREISHGLWEGKFESEIEADYPGLLEQWQSRPETVQMPEGENLQQVWDRAIAGWNEIVKNAQPGETVLVVAHDAINKAILCYISGLTTASFWNFKQGNGAVSVIDYPKGNDATPLLMAMNITTHLGGVLDKTAAGAL
>NZ_AP018203.1|WP_017290747.1|6245360_6245759_+|DUF3110-domain-containing-protein
MQVFVLLFNADTDNPGIHTISVGTQNLVLMFAQQDDAERYAMMLEAQDFAVPTVEKIDQEEIEEFCQDAGYEAYLIPENFMPQNEFERLLLAPPEANREETDWSSEDKPEREESELSNGELDRIRRQLEGLL
>NZ_AP018203.1|WP_017290748.1|6246007_6246379_-|VOC-family-protein
MNSNPVIWFEIYVQDMDRAKAFYESVFQRKLESLNNPDLEMWSFPMQMGSEGAAGALVKMPGVSSGGNSTLIYFSCDDCAVEESRVKEFGGRIQKTKMSIGEYGFISLVADTEGNLFGLHSMQ

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP018203_11	11.4|4238606|18|NZ_AP018203|CRT	4238606-4238623	18	NZ_AP018203.1	4238690-4238707	1	0.944

1. spacer 11.4|4238606|18|NZ_AP018203|CRT matches to position: 4238690-4238707, mismatch: 1, identity: 0.944

atcgtggttggtgtcacg	CRISPR spacer
atcgtggttggtgtcgcg	Protospacer
***************.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP018203_6	6.1|2607443|28|NZ_AP018203|CRISPRCasFinder	2607443-2607470	28	NZ_CP040831	Paenibacillus polymyxa strain ZF129 plasmid pAP2, complete sequence	25256-25283	6	0.786
NZ_AP018203_6	6.1|2607443|28|NZ_AP018203|CRISPRCasFinder	2607443-2607470	28	CP036360	Agrobacterium sp. 33MFTa1.1 plasmid p_JBx_073812, complete sequence	409922-409949	6	0.786
NZ_AP018203_6	6.1|2607443|28|NZ_AP018203|CRISPRCasFinder	2607443-2607470	28	NC_027331	Citrobacter phage Moon, complete genome	10532-10559	7	0.75
NZ_AP018203_6	6.1|2607443|28|NZ_AP018203|CRISPRCasFinder	2607443-2607470	28	MG250484	Citrobacter phage CF1 ERZ-2017, complete genome	10690-10717	7	0.75
NZ_AP018203_6	6.1|2607443|28|NZ_AP018203|CRISPRCasFinder	2607443-2607470	28	KT001915	Citrobacter phage Merlin, complete genome	10545-10572	7	0.75
NZ_AP018203_1	1.1|920|31|NZ_AP018203|CRISPRCasFinder	920-950	31	MH513984	Mycobacterium phage Steamy, complete genome	12235-12265	8	0.742
NZ_AP018203_15	15.1|6234910|31|NZ_AP018203|CRISPRCasFinder	6234910-6234940	31	NZ_CP035392	Bacillus subtilis strain SRCM103689 plasmid unnamed1	20281-20311	8	0.742
NZ_AP018203_11	11.3|4238558|30|NZ_AP018203|CRT	4238558-4238587	30	MN693491	Marine virus AFVG_25M150, complete genome	18633-18662	9	0.7
NZ_AP018203_15	15.1|6234910|31|NZ_AP018203|CRISPRCasFinder	6234910-6234940	31	MH447526	Sulfolobus filamentous virus 1 isolate S48, complete genome	7120-7150	9	0.71
NZ_AP018203_15	15.1|6234910|31|NZ_AP018203|CRISPRCasFinder	6234910-6234940	31	MK064562	Sulfolobales Beppu filamentous virus 1 clone A, partial genome	7931-7961	9	0.71
NZ_AP018203_4	4.3|1072472|34|NZ_AP018203|CRT	1072472-1072505	34	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	1148949-1148982	10	0.706

1. spacer 6.1|2607443|28|NZ_AP018203|CRISPRCasFinder matches to NZ_CP040831 (Paenibacillus polymyxa strain ZF129 plasmid pAP2, complete sequence) position: , mismatch: 6, identity: 0.786

tggcgtttctttcacttctggagcagtc	CRISPR spacer
gagcttttctttcacttccggagcaaac	Protospacer
 .** *************.******. *

2. spacer 6.1|2607443|28|NZ_AP018203|CRISPRCasFinder matches to CP036360 (Agrobacterium sp. 33MFTa1.1 plasmid p_JBx_073812, complete sequence) position: , mismatch: 6, identity: 0.786

tggcgtttctttcacttctggagcagtc	CRISPR spacer
atgcgtttctttcatatctggagcattg	Protospacer
  ************. ********* * 

3. spacer 6.1|2607443|28|NZ_AP018203|CRISPRCasFinder matches to NC_027331 (Citrobacter phage Moon, complete genome) position: , mismatch: 7, identity: 0.75

tggcgtttctttcacttctggagcagtc	CRISPR spacer
aggcttttctttcactactggagcgaca	Protospacer
 *** *********** *******... 

4. spacer 6.1|2607443|28|NZ_AP018203|CRISPRCasFinder matches to MG250484 (Citrobacter phage CF1 ERZ-2017, complete genome) position: , mismatch: 7, identity: 0.75

tggcgtttctttcacttctggagcagtc	CRISPR spacer
aggcttttctttcactactggagcgaca	Protospacer
 *** *********** *******... 

5. spacer 6.1|2607443|28|NZ_AP018203|CRISPRCasFinder matches to KT001915 (Citrobacter phage Merlin, complete genome) position: , mismatch: 7, identity: 0.75

tggcgtttctttcacttctggagcagtc	CRISPR spacer
aggcttttctttcactactggagcgaca	Protospacer
 *** *********** *******... 

6. spacer 1.1|920|31|NZ_AP018203|CRISPRCasFinder matches to MH513984 (Mycobacterium phage Steamy, complete genome) position: , mismatch: 8, identity: 0.742

ctttttcgcctctgccttcgcagcttccttc	CRISPR spacer
cctcttcgcctcggccttcgcagcgtcgaca	Protospacer
*.*.******** *********** **  . 

7. spacer 15.1|6234910|31|NZ_AP018203|CRISPRCasFinder matches to NZ_CP035392 (Bacillus subtilis strain SRCM103689 plasmid unnamed1) position: , mismatch: 8, identity: 0.742

acggacagtgcggttttgccgattcgtaaat	CRISPR spacer
tcggacggtgcggttttggcgattccttttg	Protospacer
 *****.*********** ****** *    

8. spacer 11.3|4238558|30|NZ_AP018203|CRT matches to MN693491 (Marine virus AFVG_25M150, complete genome) position: , mismatch: 9, identity: 0.7

atcgtggttggtgtcgctagtggtatcgtg	CRISPR spacer
caagtggttggtattgctagtggtataaaa	Protospacer
   *********.*.*********** . .

9. spacer 15.1|6234910|31|NZ_AP018203|CRISPRCasFinder matches to MH447526 (Sulfolobus filamentous virus 1 isolate S48, complete genome) position: , mismatch: 9, identity: 0.71

acggacagtgcggttttgccgattcgtaaat	CRISPR spacer
aacacgagtgcggtttttccgattagtaaca	Protospacer
*  .  *********** ****** ****  

10. spacer 15.1|6234910|31|NZ_AP018203|CRISPRCasFinder matches to MK064562 (Sulfolobales Beppu filamentous virus 1 clone A, partial genome) position: , mismatch: 9, identity: 0.71

acggacagtgcggttttgccgattcgtaaat	CRISPR spacer
aacacgagtgcggtttttccgattagtaaca	Protospacer
*  .  *********** ****** ****  

11. spacer 4.3|1072472|34|NZ_AP018203|CRT matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 10, identity: 0.706

aaaagatgatgcttgttgtgccagctgatcggat--	CRISPR spacer
aaacgctgatgcttgttgtgccag--agtccagcga	Protospacer
*** * ******************  ..** ...  

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2161778 : 2170265	10	Bacillus_virus(16.67%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_AP018203|2161778:2170265|DBSCAN-SWA
TCTACAGTAACCGCAACTGCGTCTCTTCAACGCCTGCTTCTGTTTCGATGTAAAACTCTTCTTGAGCGAGCAAAGCTTTTGCTGCTTCTAGAATCGGTTCTGCTAAAAGCTTCAGGTCTTCTCGATTGGCTAAATAGGCCTGCAATGCATCTAAAGGCGCGATCGCGCTGCCAACGCCCAATTCTGGTAAGCGCGATCGCGACATTTGACTGATTAAGCCTGCCTGAATCGTGTAAGTATGAGCAACTTCTAGCGTTTCATGCAAAATTGCATCATCGATTAAGTCAATTTGCTCTGGGCGAACTTGATAAATGACGCGCACGACTGCATCGGTGATGTCTCTTTTTGCGATCGCGTTGAGTAAATCGGCTTGAGGCGTGTCGGATTCGGTTAAATCTACTTCAATTGTGCAGAACGATCGCACTGGCAAAGGACAAAACTCGATCGCTGTAGAGCCACGTTCTAGATCGACTAAAACAAAGCCTTTCTCTTCGTGTTCTTCACTAAAATCAACTCGTTCAATACTTCCTGGATACACGACGAACGGATCTTCTGACAAAATTTGATGTCGATGCACATGTCCCAATGCCACATAATCGAACGCGTCGCGAGTTAGAAACTCCAATGGAATTGTGAATCCTTTTCCAACCGCAAGAAACCGCTCTGCGCCATAGTGAGCAGCATCGACCATTAAATGTGCGAGGAGAACCGTTGGGATTTCTGGATCAAGCTTGCGAATTTCGCCTTCCATTGCAACTCTTAATCGATCGAGTAATAAATGCCCGACATCCGACATGGATAATCCTTCGGTTTCGGGTCGCGTTAATAACGTCGATCGCGTTAACCACGGCAAGGTAATGATTTGCACGTCTCCGCTGCGGGTTTGAAGGCGATACGTTTCTAAGCGATCGCCTACAATCACATTCGGAACGCACAAGGTTCGATAAATGCACAAACTTGCGCCTCCAACTCCTTGAGAATGTTGGTCATGATTGCCAACGAGTAGAACGGCTGGAATATCTGCATCCACTAAGCGACGAAATTGACGGGCAAAGGCTTGCTGAATGTAAGGTGGCGGAGTGGCATCTGGGAAGGCATCGCCACCAAATAACACTAGGTCAACTGATTCAGAAATCGCACGATCGATACAGCGCGCCAAGGTAGCGACAAAATCCTCCAGTCGAGTATTCAACCCAGTTTCAGGGTTAATCTTGCCGTGAGCAAACCCGCTTCCAAGATGAATGTCCGACAGGTGGAGAATTTTGACCATACCGATCAGTGAAAGTTACTGCGAATAATTGTACTAAAGATATGGCTGGGCAGGAGCTTTCTTAAGATCACCGCAGTCCATGCGCCCGGATCAGCCGGATATCGCAGCCTTCGAGACGGATCGGTTGCAGCTTTGTAAATCGTTTTGGCAACGACTTCGGGTGCAGGTGCTTTTTCTCCAGCTTGGTTCATCTTCGGAATGATCTTGTTGACGTACTCGTCGTAAACCTTGAGATCTGAAGTCGCAATCTCAGGAGAGCGATCGTAGAAATCCGTTTTAATCGGGCCAGGTTCGATCAGTTTGACGCGAATATTGAATTGCTCTAATTCGTACTGCAATCCTTCTGAAAAGCCTTCTACTGCCCATTTTGTCGAGTTATAGAGCGAGTAAGTTGGAAAAGACATTTTTCCACCGATCGAGGCAACGTTGATAATCACGCCCGATCGGGACTCCCGAAAATGCGGCAATAAGGCGCGTGTGACTTCCATTAAGCCGAATACATTCGTGTCAAACTGCCGTTGGATTTGAGCCGGGGAGCAATTCTCGAATGCGCCCATAAGACCATAGCCTGCATTGTTGACGAGAACATCAATTTTGCCGAATTCAAGAGATTTTGCGATCGCAGTATGAATCGAATCTGAATTTGTCACATCTAGCGGCAGAACGTGTATCTTGTCGGATGAGAAATTTGCCTTTTCTGGATTTCGCATGGTTGCAATTACGTTCCAGCCTTTTTCAGCAAACAAAATCGCAGTCGATCGACCAATTCCCGTCGATGCACCCGTAATGAGAACTGTTTTAGACATAAGATTTCAGTGAGTTGCGACGAGAATACAAATGAAACTAATTCTGTACAGTAAGCCAGGATGCCATCTCTGTGAAGGATTGCAAGAAAAACTTGAGCAGATTCACTCGCTCGCTTTTGATCTTGAGGTTCGAGATATCACCACTCGTGAGGATTGGTTTGCGGCTTATCAGTACGAAATTCCGGTTTTGTATCTCGACGATCGTGCTCTGCCCCGTCCTTCGCCAAGGTCGTCGATCTCACAATTGGAATCTATGTTACAGAATTACATGTCAGCAAACGATTAGAAACTGAAAAACTCAGGCAAGGAGAGAGCGATGCAACTCAGAAAACTTTTGGGAGAACTTTTGGCAACGTCGGGAGAACTCCCGAATCATCCTGCATTAGAAGCCGAAGTGAAGGGACTCACGACGAATTCCTTAGCAGTTCAGCCTGGAGATGTGTTTATCGGAATGCCGGGGACGCGGGTGGATGGTGGCGATTTTTGGCAAAGTGCGATCGCTGCTGGAGCGATCGCTGCCGTTGTTTCACCTCAAGCTGCTGAAAAAGCGAAAAGCGATCCTGCCTTTCAATCTGAGAATCCGCCTTTGGTGATTCCGTCTAGCGATATGGCTCAAACTTGCGCCCAACTGGCAACGACGTTCTATCACTCTCCTGCCCAAAAGCTCAAAATGATCGGAGTCACTGGCACCAATGGTAAAACGACGACGACGCATTTAATCGAATATCTGCTAGAGCGATCGGGCAAATCTTCTGCTTTATTAGGAACGCTGTACACGCGTTGGAAAGGCTTTCAACAAACGGCACTGCATACCACTCCCTTTCCAGTTGAATTACAACATCAATTGAAAAGCGCGATCGATGTGGGATGTGATTTTGCAGTCATGGAAGTGAGTTCTCATGCATTGGCACAGGGCAGAACCTTAGGTTGTGAATTCGAGGTGGCAGTCTTTACAAATTTGACGCAAGATCACCTCGATTTTCATCGCGATATGGATGACTACTTTGCGGCAAAAGCATTGTTGTTTGATTCGGGCTATTTGAAAGGAAAAGCGATCGTCAATCTGGATGATGCCTATGGTAAGAAATTGGTAGAAAAGCTAAATCCGAAATCAGTGTGGACATACAGCACTCAAGAGAAAGCCGACCTTTGCACCAGCAATTTGCAATATGAGTCCGATGGTGTGAGTGGAACCTTGCATACGCCAATGGGAGATGCAGCCTTCAAATCGCCTTTAATTGGGCAATTTAACCTGGCAAATTTACTCGCTGCAGTTGGAGCCGCATTGCATTCTGGATTGGAATTAAGTGCGATCGTCGAAGCGCTGCCTGGTTTCTCTGGTGTTCCAGGACGCATGGAGCAAGTGCAGATTAAACCAGATCAAGACATTAGCGTAATTGTGGATTATGCCCATACGCCTGATAGTTTGGAAAACATGCTGAAAGCCTCCCGTCCGTTTATTTCAGGACAGATGATTTGTGTGTTTGGCTGCGGGGGAGATCGCGATCGTACTAAACGTCCGAAGATGGGAAATATCGCTGCAACTTTGGCAGATCAAGTCATCGTAACTTCTGATAATCCGCGAACTGAAGATCCAGAGCAGATTTTGAAGGATGTCGTGGCAGGCATTCCAGATACAGTCAATCCGACAGTAATTGCAGATCGCGCAGTTGCCATCAAAACCGCAATCATGCAGGCAAAACCGGGAGATGGAGTTTTGATTGCAGGCAAGGGGCATGAAGATTATCAAATTTTAGGAACGGAGAAGATTCATTTTGACGATCGAGAACAGGCGCGGGCGGCGTTAAGCGATCGGTATTAATTTGAGTGATAGCTGTAGGGAGTGGGGAGTGGGGGAATGAGAAATTGCCTGACTCTCCTACTCGTTTACCACAATCAATCTGATAGAGGGATTAGAAAAAACCGGACTCAGAGTGCTCTCTAGTTCCCCACTCTGCAAAATTCATGCGGTTGACTACTCCCTACTCCCCACTCCCCACCATTTTCCCCTCCCACCCATGCCTCGATCCTCAATCTCCCTGATAGGATGGAAAAGCCGAAAACGAAGGGCTTAGATTATGACTCGCGCAATCATGGAAACCGACAAGGGCACAATCAATCTCGAATTGTTTGACAAAGATGCCCCAAACACCGTCAAGAATTTTGTCGATTTAGCAAACAAAGGCTTTTACGATGGGCTTGCATTCCATCGCGTCATTCCCAACTTTATGATCCAAGGTGGATGTCCGAACTCGCGGGAAGGCGCACCTGGAATGCCAGGAACCGGAGGCCCCGGCTACAAAATCAACTGCGAAATCAACCCGAACAAGCACGAAGCAGGCAGCCTATCGATGGCTCATGCTGGACGCAACACGGGCGGCAGCCAATTCTTCATCTGCCATTCTGCACAGCCTCACCTCGATGGCGTGCATACCGTCTTTGGCAAAACCGAAGATATGGATGTTGTGAATGCAATTCGTGGAAACGATCGCATTCTTTCCGTCAAGATCGAAGGCTAAACTCTGCCATATTTCGCGATCGCATTGGCTGATGAATCTGCTTGATTTGTCAGCCATGCCCAAATCTGATCTCCGTAAGAAAAGTGCCACCATTCGTTCCAGTGTTGCTTAAATCCGGCAGCGGTCATTGCGTTTGATAGAATTTTGCGATGCTGACCGTATTCTGAATCTGGTGGGAAATGATTTGGAAACGATCGCTCAGAAATCTCATCAATTTCTGATCCCATATCGATGACATTGCCATTGTCATCAATTAAAGTAATGTCGATCGCGGCTCCCGTACTATGAGGTGGAGGTGTCGCAGGATCTAGATTCGGCATTGCCCAAAATTGATAGACTTGTTGCTGAAATTCTTCTCTCTGCGTTTCTGAAAGTGTTTCTAATTGCAATCCATTTGCATTGACTAATTCTGTAAACGTGTAATCGACCATAAATTGCTGAACTGCAACTGGGCGATAGGCATCAAAGATTTGGATTTTCCAGCCGGGTCGAATTTTCTGCAATTCTGCATCGGCTTGAATTAAGCGATCGAGAATTCCTGCTCTGACAAAAAATGGCGACTTCTCTCCATAAGGTGCGCCTAATTTTGCATAAGGATGTGGGGTGACTCGATCGAACTGCTCTGAAATTTCGACCAGAGGTTCATGGCATTCGGCGATCGCAACTTTCTGATAAGGTTTCATCTTTTTTCGGTGGAACAGGATCATAACCGCCCGGATTGAGCGGATGACAGCGACAAATTCGACGCACCGAGAGCCAACTGCCCTTGAGTACGCCATGTGTTTCTAAAGCCTCGATCGCATATTGTGAACAGGTTGGATAAAACCGACAAGTCGGCGGAAACAACGGTGAAATTGCGATACGATAGCCTCTTACCAATCCGATCAGCAGAATTTTCATGTCTTCGATCGTAGTTCAAAACTCTATCCTATGTCTTACTTTCGCCCAAGTGTGGATGCAATGGCGGGCTATGTGCCAGGAGAACAGCCGAAACCTGGAACGCCCATCATTAAGCTAAATACGAATGAGAATCCCTATTTGCCTTCGCCGAATGCGATCGCAGTTCTGAAAAGTCTCGATCCCGAATGGCTTCGCCGCTACCCTGATCCCTATGCAAATGATTTCAGACAAGCGACAAGCGAAGCATTGAACATTCCCAAAGATTGGATCATGGTAGGAAATGGCAGCGATGACATGTTGAATGTTGTCGTGAGAGCCTGTGCAGAGCCGGGGCGTAAAGTCGTGTATCCGATGCCGACTTATGTCCTGTATCGGACTTTGACGGAAATTCAAGATGCCGATCGCTTAGAAATTCCTTATGGTGAAAACAATCAATTACCACTAAATGAACTGATTGCAGCTCAAGGGGCTGTAACTTTTATTGCTTCTCCGAATAGTCCTTCAGGGCATGTAGTTGCAATGTCCGATCTGCGTCAACTTGCCGCAAACTTGAACGGCGTACTTGTGATTGATGAGGCATATGTCGATTTTGCTGAAGAGACCGCTTTGCCTTTAGTAGAACAGTTTCAGAATGTGATCATTTTGAGAACGCTTTCAAAAGGCTACAGTTTAGCAGGATTGCGGCTTGGATTTGCGATCGCGCAACCTCACCTCATTCGAGGCTTATTCAAAGTTCGTGATAGCTATAGTGTCGATGCGATCGCAACTTTAGTTGGTGCTGCCGCAATGCGTGACCAGGACTATAAAAATGAATGTGCGGAAAAAGTGAAGAGATCGCGAGAAAAATTAGCGATCGAACTTAGACAGTTAGGCTTTGAGGTCTGGAATTCTCAAACAAATTTCCTCCTCACTCAACCTCCAGGCAATGCTGCAAAAATCTATGAGGCGCTTAAGCAGCAAAACATCCTAGTACGCTACTTCAACCAACCAAACCTTGATGACAAACTTCGGATCAGCGTTGGTACAGATGAACAGAATCGAATTCTTATCACCACTCTTTCATCTCAACTCTAGTCGGTCATAGATTAGCGTTCTCATTTATCATCCCCGAAGATAACAGCCATCACGTCAGCCGCTGTTCCTCGTTCTGCTGTGCCATTCCTGACAGCTTCCAGTGTCTTTTCTGCATTTTGAGCAATTTTCTGCCTCCGCTTCATCACCCGCCGTTTCTGAATCAAATCAAACAACTCATTCTGTTCATCCTCAGAGAGTGCTTCGACGTATTCAATAACCGTTTGAAAAGGCATCGCTTGAGTCATAGGGCATGTATTCACGAGTACTTCTCAAGTATATTCAGCCAAATTCTGGTCAGAATAACAAACTATTCAGCAGAGTAGCTAACTCAACTGGACAACTGCTTGATCTTCAACCAATGTTCGAGCCGTCAGTAAATCTTCCACCGTAATCCGCAAAAAACGATCGCGATCGACCATGAACTGCACCTTAATGCGATCGCTTCCCGGACTTCCCGGCGGATCGAGTTCAGCAATGCTCCGTGATCCATCTTTATCATTCAACGCCTGCACCTGCGTTTGTGAGCTTGAAACATTGCGAGTTACTAAGCGATCGCCATCAAAGTAAACCTCGGTCTGAACTGTTTCGGCTCCTAACTCACCTACAATCAGTTCAATACTTGGCTGGCTCTCTAACGACGCTCCTAGCACCAATTCGACAGGATTCTCCATCGGGTAAGGCTGTCCTGCTTTAATTAAAGGATGCCAATTATGGCGATTCTGCCGCCGATCCCAATAGCGAATTCCATAGCCGTGATAGAGAAAATCTTTTAGCTCAATGCCTTGGCTCAGTTGCAATGCCCCTTGAGCGATCGCTTCAAACGGCTTTTCACACCGAATCAAACGTTCATCAAAATATTGCTTCACCCAGTTCTGCACCGCTGGAATCTGAACCGTTCCACCGACCAGTAAAACCGCATCAATATCGCTCACGGCTAAGCCTTGTCTTCGGGCTTGTTGCAGCACTTGCTCCATCGATTCATCGAGCTTCGTAAAGAAACCGCGATCGCTCAAAATCTGCTCAAACTGCGATCGCGTTAAAGACAAGTCATAGCTTTCAAAACGCTCATCATCAAAGAAAACTTCCTGCGCTTCAGTGAAGAGCGAAAGCTGAATTTTCAATCGTTCTGCCAATCTCGAAATTAATGGCGTTGCTGTGAATCCTTGTGTATTCACAAAATGATCGACAAGCCAATTATCCAGATCCGATCCGCCTAAATTTTGTCCAGCTTTTGCAATCACTCTCGCTGTCTTTGCTTGTTGTCCTGACTGTTCCTTAAATGATTTCTGTCCCCATTTCAAAATAAATCCTGTCGGCTTTGCCGATTGATTCACATTCGTTTGAACAATCGACAAATCCAGTGTTCCCCCGCCAAAGTCAACCACGAGTAAAGTTTGTCGATCGACAAATCCATATCCCAATGCCGCTGCTGTTGGCTCATCAATCATCCGCACCTGATTAATATCCAAAGACTCACAAATCTGCCCGAGCCAAAGCCGATACGCTTCAAAACTATCCACTGGGACAGTAAAGACAATTGACTCTGCAATCTCTGGATCGGTCGTTTTCAACTGATTGATAATTTGGGTGAGATACCACTCGCCCACCTGCTCAAATCGAATCACCTGACCATCTAATTCGGGCAGAAATCCTTGCACCTCTGTTCCGATCCCGCGCTTGAAGTTGCGGAAAAATCGGGAGTCCTGACTGATATCTAAACCACGATCGCGTACCTCCTGCCCGATCGTAACTTTGCCCTGTGCTGCATTTTCGGCATACAACAAACTGGGGATCAGCGATGGATTCTGGGCGAGACGTTGAGAAATTCCTGGAATTGCTAAAGTTTCTGGCTGCTGAGTCACAGCATTCCAGCGCGTAATGACGGTGTTACTGGTTCCGAAATCGATCGCGTAGGGCAT

Protein sequences of DBSCAN-SWA_1

>NZ_AP018203|2161778:2170265|2164169_2165675_+|WP_017286738.1|DBSCAN-SWA
MQLRKLLGELLATSGELPNHPALEAEVKGLTTNSLAVQPGDVFIGMPGTRVDGGDFWQSAIAAGAIAAVVSPQAAEKAKSDPAFQSENPPLVIPSSDMAQTCAQLATTFYHSPAQKLKMIGVTGTNGKTTTTHLIEYLLERSGKSSALLGTLYTRWKGFQQTALHTTPFPVELQHQLKSAIDVGCDFAVMEVSSHALAQGRTLGCEFEVAVFTNLTQDHLDFHRDMDDYFAAKALLFDSGYLKGKAIVNLDDAYGKKLVEKLNPKSVWTYSTQEKADLCTSNLQYESDGVSGTLHTPMGDAAFKSPLIGQFNLANLLAAVGAALHSGLELSAIVEALPGFSGVPGRMEQVQIKPDQDISVIVDYAHTPDSLENMLKASRPFISGQMICVFGCGGDRDRTKRPKMGNIAATLADQVIVTSDNPRTEDPEQILKDVVAGIPDTVNPTVIADRAVAIKTAIMQAKPGDGVLIAGKGHEDYQILGTEKIHFDDREQARAALSDRY
>NZ_AP018203|2161778:2170265|2168669_2170265_-|WP_017286744.1|DBSCAN-SWA
MPYAIDFGTSNTVITRWNAVTQQPETLAIPGISQRLAQNPSLIPSLLYAENAAQGKVTIGQEVRDRGLDISQDSRFFRNFKRGIGTEVQGFLPELDGQVIRFEQVGEWYLTQIINQLKTTDPEIAESIVFTVPVDSFEAYRLWLGQICESLDINQVRMIDEPTAAALGYGFVDRQTLLVVDFGGGTLDLSIVQTNVNQSAKPTGFILKWGQKSFKEQSGQQAKTARVIAKAGQNLGGSDLDNWLVDHFVNTQGFTATPLISRLAERLKIQLSLFTEAQEVFFDDERFESYDLSLTRSQFEQILSDRGFFTKLDESMEQVLQQARRQGLAVSDIDAVLLVGGTVQIPAVQNWVKQYFDERLIRCEKPFEAIAQGALQLSQGIELKDFLYHGYGIRYWDRRQNRHNWHPLIKAGQPYPMENPVELVLGASLESQPSIELIVGELGAETVQTEVYFDGDRLVTRNVSSSQTQVQALNDKDGSRSIAELDPPGSPGSDRIKVQFMVDRDRFLRITVEDLLTARTLVEDQAVVQLS
>NZ_AP018203|2161778:2170265|2167014_2167272_-|WP_017286741.1|DBSCAN-SWA
MKILLIGLVRGYRIAISPLFPPTCRFYPTCSQYAIEALETHGVLKGSWLSVRRICRCHPLNPGGYDPVPPKKDETLSESCDRRMP
>NZ_AP018203|2161778:2170265|2163884_2164139_+|WP_017286737.1|DBSCAN-SWA
MKLILYSKPGCHLCEGLQEKLEQIHSLAFDLEVRDITTREDWFAAYQYEIPVLYLDDRALPRPSPRSSISQLESMLQNYMSAND
>NZ_AP018203|2161778:2170265|2165931_2166372_+|WP_017286739.1|DBSCAN-SWA
MTRAIMETDKGTINLELFDKDAPNTVKNFVDLANKGFYDGLAFHRVIPNFMIQGGCPNSREGAPGMPGTGGPGYKINCEINPNKHEAGSLSMAHAGRNTGGSQFFICHSAQPHLDGVHTVFGKTEDMDVVNAIRGNDRILSVKIEG
>NZ_AP018203|2161778:2170265|2161778_2163047_-|WP_017286735.1|DBSCAN-SWA
MVKILHLSDIHLGSGFAHGKINPETGLNTRLEDFVATLARCIDRAISESVDLVLFGGDAFPDATPPPYIQQAFARQFRRLVDADIPAVLLVGNHDQHSQGVGGASLCIYRTLCVPNVIVGDRLETYRLQTRSGDVQIITLPWLTRSTLLTRPETEGLSMSDVGHLLLDRLRVAMEGEIRKLDPEIPTVLLAHLMVDAAHYGAERFLAVGKGFTIPLEFLTRDAFDYVALGHVHRHQILSEDPFVVYPGSIERVDFSEEHEEKGFVLVDLERGSTAIEFCPLPVRSFCTIEVDLTESDTPQADLLNAIAKRDITDAVVRVIYQVRPEQIDLIDDAILHETLEVAHTYTIQAGLISQMSRSRLPELGVGSAIAPLDALQAYLANREDLKLLAEPILEAAKALLAQEEFYIETEAGVEETQLRLL
>NZ_AP018203|2161778:2170265|2168366_2168591_-|WP_017286743.1|DBSCAN-SWA
MTQAMPFQTVIEYVEALSEDEQNELFDLIQKRRVMKRRQKIAQNAEKTLEAVRNGTAERGTAADVMAVIFGDDK
>NZ_AP018203|2161778:2170265|2163052_2163853_-|WP_017286736.1|DBSCAN-SWA
MSKTVLITGASTGIGRSTAILFAEKGWNVIATMRNPEKANFSSDKIHVLPLDVTNSDSIHTAIAKSLEFGKIDVLVNNAGYGLMGAFENCSPAQIQRQFDTNVFGLMEVTRALLPHFRESRSGVIINVASIGGKMSFPTYSLYNSTKWAVEGFSEGLQYELEQFNIRVKLIEPGPIKTDFYDRSPEIATSDLKVYDEYVNKIIPKMNQAGEKAPAPEVVAKTIYKAATDPSRRLRYPADPGAWTAVILRKLLPSHIFSTIIRSNFH
>NZ_AP018203|2161778:2170265|2166368_2167055_-|WP_017286740.1|DBSCAN-SWA
MKPYQKVAIAECHEPLVEISEQFDRVTPHPYAKLGAPYGEKSPFFVRAGILDRLIQADAELQKIRPGWKIQIFDAYRPVAVQQFMVDYTFTELVNANGLQLETLSETQREEFQQQVYQFWAMPNLDPATPPPHSTGAAIDITLIDDNGNVIDMGSEIDEISERSFPNHFPPDSEYGQHRKILSNAMTAAGFKQHWNEWWHFSYGDQIWAWLTNQADSSANAIAKYGRV
>NZ_AP018203|2161778:2170265|2167302_2168346_+|WP_017286742.1|DBSCAN-SWA
MSYFRPSVDAMAGYVPGEQPKPGTPIIKLNTNENPYLPSPNAIAVLKSLDPEWLRRYPDPYANDFRQATSEALNIPKDWIMVGNGSDDMLNVVVRACAEPGRKVVYPMPTYVLYRTLTEIQDADRLEIPYGENNQLPLNELIAAQGAVTFIASPNSPSGHVVAMSDLRQLAANLNGVLVIDEAYVDFAEETALPLVEQFQNVIILRTLSKGYSLAGLRLGFAIAQPHLIRGLFKVRDSYSVDAIATLVGAAAMRDQDYKNECAEKVKRSREKLAIELRQLGFEVWNSQTNFLLTQPPGNAAKIYEALKQQNILVRYFNQPNLDDKLRISVGTDEQNRILITTLSSQL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017286735.1|2161778_2163047_-	exonuclease subunit SbcD	G3MA97	Bacillus_virus	7.8e-32	28.0
WP_017286736.1|2163052_2163853_-	SDR family oxidoreductase	A0A0N9R355	Chrysochromulina_ericina_virus	3.4e-09	25.5
WP_017286737.1|2163884_2164139_+	glutaredoxin family protein	NA	NA	NA	NA
WP_017286738.1|2164169_2165675_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase	NA	NA	NA	NA
WP_017286739.1|2165931_2166372_+	peptidylprolyl isomerase	A0A1V0S9I2	Catovirus	1.6e-16	43.8
WP_017286740.1|2166368_2167055_-	hypothetical protein	NA	NA	NA	NA
WP_017286741.1|2167014_2167272_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	2.8e-21	55.1
WP_017286742.1|2167302_2168346_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	3.2e-23	25.5
WP_017286743.1|2168366_2168591_-	hypothetical protein	NA	NA	NA	NA
WP_017286744.1|2168669_2170265_-	Hsp70 family protein	F2Y2E1	Organic_Lake_phycodnavirus	1.0e-17	25.2