CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_AP018279	Calothrix sp. NIES-4101 plasmid plasmid6 DNA, complete genome	0 crisprs	NA	0	0	0
NZ_AP018280	Calothrix sp. NIES-4101 DNA, complete genome	14 crisprs	RT,c2c5_V-U5,csa3,Cas9_archaeal,WYL,cas3,cas10d,csc2gr7,csc1gr5,cas6,cas4,cas1,cas2,c2c9_V-U4,DinG	1	8	7
NZ_AP018278	Calothrix sp. NIES-4101 plasmid plasmid5 DNA, complete genome	0 crisprs	RT,PD-DExK	0	0	0
NZ_AP018275	Calothrix sp. NIES-4101 plasmid plasmid2 DNA, complete genome	0 crisprs	Cas9_archaeal	0	0	0
NZ_AP018274	Calothrix sp. NIES-4101 plasmid plasmid1 DNA, complete genome	6 crisprs	cas3,DinG,cas6,RT	0	3	2
NZ_AP018277	Calothrix sp. NIES-4101 plasmid plasmid4 DNA, complete genome	0 crisprs	RT	0	0	1
NZ_AP018276	Calothrix sp. NIES-4101 plasmid plasmid3 DNA, complete genome	0 crisprs	NA	0	0	3

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP018280_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_1

615672-615783

Orphan

Consensus_repeat	Method
CCTGGACACTTATCCCACAACTGCGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_1

>merge|NZ_AP018280|1|615672-615783|CRISPRCasFinder
CCTGGACACTTATCCCACAACTGCGATCGCACAAACATATTCCCAGGGGTGACAACCCAAATAAACCAATAACTATATTTATTCAGCCTGGACACTATCCCACAACTGCGAT

>NZ_AP018280|1|1|615672-615783|CRISPRCasFinder
CCTGGACACTTATCCCACAACTGCGAT	CGCACAAACATATTCCCAGGGGTGACAACCCAAATAAACCAATAACTATATTTATTCA
GCCTGGACACTATCCCACAACTGCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096614705.1\|622176_623187_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614696.1\|608023_608344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614707.1\|624147_627015_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274279
NZ_AP018280.1\|WP_096614708.1\|626965_627817_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614699.1\|611340_613524_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380205
NZ_AP018280.1\|WP_096614695.1\|605866_607702_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614691.1\|603857_604136_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614700.1\|616108_616456_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614702.1\|617379_617835_+\|phosphatase	unknown	unknown	gnl\|CDD\|350353
NZ_AP018280.1\|WP_096614694.1\|605162_605813_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614701.1\|616585_617392_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033
NZ_AP018280.1\|WP_096609659.1\|628780_629032_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614693.1\|604750_605176_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614692.1\|604226_604748_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614703.1\|617895_618270_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NZ_AP018280.1\|WP_096614706.1\|623812_624148_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614698.1\|611071_611338_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614704.1\|621528_621807_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614690.1\|603482_603716_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614697.1\|609648_610812_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096614702.1\|617379_617835_+\|phosphatase	gnl\|CDD\|350353	cd14503, PTP-bact, bacterial tyrosine-protein phosphataseS similar to Neisseria NMA1982. This subfamily is composed of bacterial tyrosine-protein phosphatases similar to Neisseria meningitidis NMA1982, which displays phosphatase activity but whose biological function is still unknown.	4.31363e-50
NZ_AP018280.1\|WP_096614697.1\|609648_610812_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.75491e-24
NZ_AP018280.1\|WP_096614699.1\|611340_613524_-\|hypothetical-protein	gnl\|CDD\|380205	NF033203, entero_EhxA, enterohemolysin EhxA. Members of this family are the RTX toxin called enterohemolysin or EhxA, because it is found in enterohemorrhagic Escherichia coli (EHEC) strains such as O157:H7.	9.43862e-22
NZ_AP018280.1\|WP_096614707.1\|624147_627015_+\|hypothetical-protein	gnl\|CDD\|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	1.44393e-07
NZ_AP018280.1\|WP_096614703.1\|617895_618270_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	2.26553e-25
NZ_AP018280.1\|WP_096614701.1\|616585_617392_+\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	2.05429e-35

>NZ_AP018280.1|WP_096614699.1|611340_613524_-|hypothetical-protein
MTVLWNESVNGDFSNDARNPTALGPLSLGSNLITAALPESPQDNLDVFSFVVPDGFIVSAINVAKLDITGFSSGFTLFLDNSQGTSVGSLNASGSGLKTGDNLFTINGFFDNGFGGPLTAGVYVFDLRAFGPTFGANAYEFDLVLSPPNTAPTAVNFTPPTTALDENTNTANRIKVADITITDDGQGTNNLSLTGTDAGVFELDGTTLYLKAGTVLDYESGKTSYSVAVNVDDPTVGTTPDLSKTFTLQVNDLVENTAPTDLALSSTTVNERVEANTSVGTFSTTDAEGGNFTYELVSGDGSTDNTSFTIDGNQLKINASPNFEAQSSYSIRVKTTDAGGLSYEEALTITVNDVNEVPIFTSGATASFAENNTGTVYTASATDPEKTTLVYSLAGTDGALFDINTNTGAVIFKATPNFEAPTDSNGDNVYDLQVTASDGTLSTSQAVAITVTDVNEAPTVTGETVSTSQNTGAPITSVTVKLGDNLSDPDANGLANAILNVTGTTNGTVSSIDQDARLVSFTPTAGFSGTASFNYTLTDAGSLVSNTATVTVEVGSVISTGNRNQDIEGNNGDDIISAGNGSDRIQGLGGNDWLSGNNGNDTLDGGDGNDSLFGGNGNDSLFGGNGTDTLLGGNGNDLLDGGNGPDILTGGAGSDQFVLNQTAGGDTITDFNVTEDRFALSGGLTFGRLSFVNIGSNTLINTGTETLATVNNVSANLLNNSSLFGSV
>NZ_AP018280.1|WP_096614698.1|611071_611338_+|hypothetical-protein
MYKTTALQSALNTRSPIHFWKSDLDLGSDRIQAQTRLLTLCLIWDFVHTKNVTIHEGCKAYLTGLLMDNLTSRTKLLETAQILTKYTA
>NZ_AP018280.1|WP_096614697.1|609648_610812_+|site-specific-integrase
MASNASQRKASKGTVQIKISNDRLQLVFSFGGKRHYLSTGYTDSKANRKLAEMKARQIELDILCNNFDVTLERYKPQSQQVEFTTTSENKTHASLADLWDSYTEYKRSSLSPSTLAKDYHKIYRCINVHLPVRTLDKAIAIRDWLVANKSPLSAKKILTQFSACCDWAVRSGLIGENPFEGMASDIKVPKGDREETDINPFSLEERDRIIAAFQENRYYKHYATLIEFLFITGCRPSEAVALQWKHVAIDFTVLRFEQAVVISSSGLTCKPGLKTQKKRVFPINQRLAGLLRSIKPVGVSDDGKVFPSPDGKWIDVHNLSRRAWKTVLASLDGVKYRKLYQTRHTFITMALKNGVDVKDVATMVGNSPEIIYRHYAGQSRELVLPEF
>NZ_AP018280.1|WP_096614696.1|608023_608344_-|hypothetical-protein
MIKETWIGTFEGNKICYKKSFNAQNVVLSHYDYDFVIIMVIDNKTKITMVTVIDYKKEKETAIYFIDKDEYPGMMERENKDTDWEIITEYEDEIKSMFVALSKIGA
>NZ_AP018280.1|WP_096614695.1|605866_607702_+|hypothetical-protein
MVVIFNHCMENNKPVRLETPQTAYLISQFPEVEYLEAGHIAEWLSTRKDQLLILAKEERIGSSLAKTISIATAAIGAVCYATSPLAPLGAVLGVAGYVWAQITDSSNTHTFNPIPFIRGGALDVIGSLGHSEARKEFIAGYDEFDQLKDYLAPVERHEYQMLRGHMALVTEYLSQIDSGKRFYAYRWICDQFILMRGSFPSIQQTMQHTSSMQFASPLVDCDRIKSIQQASNKPESRPLIQDAPTARIQDAPLPIIQNCPTQPNEPMKTELVSFNKNIPNLVESITKKLTNTLIVGVPGVGKGIFVSNALESLKGQNITIFYLDPKDDQKENGYFDGRVNKLYRLNVAIAEPEETYQWVKDCLKEYDAFDAGSGIKLLVFDELAAVNTMLSNVKGAVNWLKSKMVSYASSGSSRGIIIWGISQNAHVSGIGFDGGARSIFTPIILISGDNITASEQILNAQIIPSDKRLNSSQITALCNKSEVNRAIFHGALNSWFPLPEFDNYSGFNRDKREFINGVNPVVSSLERMLELSKQPTQIQETKQAIINSQLLDCIIDKIASSNDVVSFEAIRSHIKRTLPDMAKKEMIENAIFNLIQSDIIQGNIEQGYTSI
>NZ_AP018280.1|WP_096614694.1|605162_605813_+|hypothetical-protein
MALGNKPHSGIPQSIPTGAGSIPQKSSPDFMQTAVSWLFKVITFPLWIVTAIFHQMLTPGASGATFLGKVIFIFLVVLSADSYWQVLFQNLSLFPWYETQWTGLGWLPELRLFPIGLSLGLFGNPIFYICITISFVIQMFQSAFVTGEKFITGNPKLLGLIAVALYSFDIIMTFTSRNPWRYESPGQVLQCILFNLFTISCAELGRWGEKVLAGKK
>NZ_AP018280.1|WP_096614693.1|604750_605176_+|hypothetical-protein
MTSRTDKYIAPFCVAGVGLLCLASPLFLNLGTQMPDYLASQQLASQQEQQRKELIERKKTSDRVKQTGLPIVGNTHTLTDYLDSPDKLPNIPKTVLNRYATTQAWVFDASDQCIGRIIKGNFISKHNSPSTCKALPNNGTR
>NZ_AP018280.1|WP_096614692.1|604226_604748_+|hypothetical-protein
MSKPIGYWGCNYDHQLIRDIAETYGDHLQHMRLTDKYWLQCHISEAIRLEIWEVEETQAAEEAGNSLHEMDQAQLQALSLALINKSHGKPITYWGCDHLNPIINGLIQVYGQYLEAMSNEDCYWLLMKIGHYLWLNHSDNAPTEEAQEVYTRITELELPFPQWDALLTAIVNS
>NZ_AP018280.1|WP_096614691.1|603857_604136_+|hypothetical-protein
MQQLDPVYDASQLSKLKIYQYKGVLYRYLCKCPYARNTYPQWIFEPLAGQRSKVNIKLNSNKIRSGSIAECTGMLATAKSQVTQSGIQQTLF
>NZ_AP018280.1|WP_096614690.1|603482_603716_+|hypothetical-protein
MDEQVFTFSDIANLLEITEDDAITGMYDCDAFFQAKFGLPTAEYSPDSVLTADKSELLTVWLTGKSPLELWVLKQNE
>NZ_AP018280.1|WP_096614700.1|616108_616456_+|hypothetical-protein
MEEQKIVRNRGDLASLNGKKVKLVGYYTSQSSKPTVTGNPDFQGVYIKSQIVLEDGTVVHIFPSWNKQSLRSPSEVQKYKGKIVQGIGVVEFEVASKINSQTRESFINLEEFKDN
>NZ_AP018280.1|WP_096614701.1|616585_617392_+|DNA-alkylation-repair-protein
MTQYLITQLQEQLAQAGDSKTKEWWEAYLKHSLPFRGLKLPQVRAILHSWAKTANFSSQPVTQQFNIAIALIQESWGEDKLAGILLLQEFLIKHRLINWESDLPKFAILFDKADIKEWNTCDWFCVKVLNPLIKQQGKPCAEAIMQWCEAENLWRKRASVVSFVNIAKHGESNFPGFSQMLLHTCGAVVQSSERFAQTGTGWVLRELSLSNRDLVIDFIKTNSIYFSSEGLRYGIEKFPPDLQQQLKQYRQEKLKSKNKPKSNIPCLP
>NZ_AP018280.1|WP_096614702.1|617379_617835_+|phosphatase
MSSLAQIEAFLPVSFTITTSGQPTPEQFADIASAGYSLVINLATRASTDWNPEENSIVENLGMEYIGIPIDWDNPTLSDFDELAAKLNENPEQKVWVHCAKNMRVSAMMYLYHRLHKGYTEVSARRYLEQIWQPNQIWQNFIDAVMELHGE
>NZ_AP018280.1|WP_096614703.1|617895_618270_+|nuclear-transport-factor-2-family-protein
MDTSNKTQVIANEKKLLEAMKSNNFELLDQLLHDDLLFNGPDGKTVTKAIDMANYRSGNINLHTVESSDLILNAINDNIVVAVTVEIQGNYLGQEINGKFRYLRVWQRFENNWQVIAGSVVSLQ
>NZ_AP018280.1|WP_096614704.1|621528_621807_-|hypothetical-protein
MFHLVTKQQASEKLNMSFSTLKKYRLDGTWIEGSHWVKLNNRCIRYNLELIQDWLHNRQDPITHHRAIDLFHASLASNQKFRPENSQVVILN
>NZ_AP018280.1|WP_096614705.1|622176_623187_+|hypothetical-protein
MNNLITNPDDLEYISDIANQVLENRQKLTDIKDLQAALKEVSLEHGREIQINLVFTENLLTGFNFSFVHDPEKTTPTIPFKPQEINIDSNHSDIIPYSQATTKIEIATTNRQGNLTIPSSSPSGIIINPGLQVEDQRIINPNDSETNQIIETPTPRLKKRNPGLINAVSQLANQHEINGLMLTGLGLKTGISVTDTLQTEEKPDIQNTGLAIIKRFQQVLPEEFMTLKAGDYPQSFKWKDPESNKQYHFYFEAAPRNEIGETITTASLKGFEIISGSDIKPVFIANLIDAKYNRWSIEQCDFNQRQIQSLNLACKSTVPHQPKTTVNNITESYLEI
>NZ_AP018280.1|WP_096614706.1|623812_624148_+|hypothetical-protein
MQEREVIKVNRILGKQAGFGPVPANQIMPWLAIITISYFIFDGLLGWGIPKVAVISFWLIISWWFVTGKDPDKYVNRFRKPKGKNWIIGGAIYVSPLISRKVRNKFKNERR
>NZ_AP018280.1|WP_096614707.1|624147_627015_+|hypothetical-protein
MKTQIQTINASKLNQKLQYIPFENELDLCCMVRIERDNRCIGGFLLNKGDISEENQFQVVFAFQIKGIHDQLYPEEVTAISTGISEAMKFILPGEKCTFLLGRYSDNSIRQQQLDRLAQNSSLPLPTILIRNEQARIQELTRKGTRSTWQQIVFCTWTADAFGENRSDLLSKLIYQVAKSGRFLLDNFTGRISQRQEQLLSQVLMKAYTEGFLQWEMLFNTKAGLEIQSLNDIELWSWLWSRFNQYSPPQIPQLLVLKEDNNSGLQLIEIQNSFKHSTTILIAGGRGKSSCPEHRQCTNRIYIKDKVCGVLTMADTVPAWISAKEQIAWMWKVMSENHVRDTEAWVEISSANRYLTEDNLHRQAKQTKVARERAFLKGSGRDVGAEIKQEESFDAQKKLYKGAVPLNCAVVFLVYRENAESLDLACDLLCNSFGTAKVVREKHIASQIWLETLPITWRRILHSSSILSERRLVLESETVAGVLPLTLPKELDSQGVEFLTNRGGKPACIDLFTHTQHALITGKTGSGKSVLLWRFMLDALSQGIPVVGMDIPAADGESSFKTAIALLGDAGAYFDLSRASNNLMEPPDLRSFDPEERASRMKSWRSFIRNALGVIVMGRLDAPHLAQRVDAILLRSLEIFLSDPDIIERYNLSFSKGWKSPEWQDTPTLKDFSRFCSTARLNISKPEAIDHQAINQITSQIAALLVSPLGNAIAKPSSFSPEPMVKFYALTGLSNDQDSYTMAVAAKAACLRVALSYPKSLFIGDELSVLFRKDGFSAMVGELCATARKDGLSIVLSSQDPDTICQSSAAAMIMQNISYRITGCITSNAVASFQNYLSYPVEIITQNASESFFPRRSDLYSCWLIEKGGRFWQTRFYPGEMSLAAVATNQEERITRREILSQYPNTLKGKLKGLANFTKVYVEAIRSNKELINTHIGASYVLEEKQSEEITNGQI
>NZ_AP018280.1|WP_096614708.1|626965_627817_+|hypothetical-protein
MSWKKNRVKKLRTVRYKGKIKSISIIGIAVISISFTAIAPPIFAATSDTKETRDISQTATDTFNKNSSGEIQAFINDVRSFVRGDFFGNISQMIKNAIGSVEVPDLGQVVSDIMKGSLPQDGATANKLENKIPNSYAIRQDLANQSERVGAIEFAQIKTLSKNAQQESKLTLDKSANSELESNQMSEDSQNSDTSQQILQNISRQLKSNSTIADLQLQEASQARQDRALGLTLTAQVAQELNAVNTRERQSAIATGNSAISQSSLFVMPGDSVFNENFPNSNN
>NZ_AP018280.1|WP_096609659.1|628780_629032_+|hypothetical-protein
MQEFKSPVSRLARLFQKGRDNWKEKALLKQKKIRALEIKVRDLLDSREEWKNRALMAESKLKELNIEGDLDEKKRKFKSKQKS

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Crispr_ID: NZ_AP018280_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_2

2568468-2569103

Orphan

NA:I-D,II-B

Consensus_repeat	Method
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	CRT
CTGATAGGGATTAGTTTGAATTGCAAT	CRISPRCasFinder
GTTTC----------AATCCCTGATAGGGATTAGTTTGAATTGCAAT	PILER-CR

8 spacers

The CRISPR arrays of NZ_AP018280_2

>merge|NZ_AP018280|2|2568468-2569103|CRT,CRISPRCasFinder,PILER-CR
ATTGTCTTATCTGATAGGGATTAGTTTGAATTGCAATCTAAAACCTAACGATATTATTGCAATCGATATCGGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATGTTTCTGTTCAAGTAAAGCTACTCTACTCGCATTTGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATTTTAAAAACCACGGTTAAGCGTAACCCTGGTGGTGCTGCCGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATTGAAAATGGCGTTGTTAATATTGGGAGATAAACATGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATTGTTAATTGTCAATGACGAATCATTAAAAGAATTAGAGATAAACATGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATGCGATCGTATTTCCGATTGCGCGTTTGGAATTATTGATGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATTTTTCTTACACTGCGGATTTTAATAAAGCCAAAGAGTTTGAGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAATTTTAGTTCTTCTCCCGCTACTGGAAGAGTCACTAGTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT

>NZ_AP018280|2|1|2568468-2569103|CRT
ATTGTCTTATCTGATAGGGATTAGTTTGAATTGCAAT	CTAAAACCTAACGATATTATTGCAATCGATATCG
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	GTTTCTGTTCAAGTAAAGCTACTCTACTCGCATTT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TTTAAAAACCACGGTTAAGCGTAACCCTGGTGGTGCTGCC
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TGAAAATGGCGTTGTTAATATTGGGAGATAAACAT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TGTTAATTGTCAATGACGAATCATTAAAAGAATTAGAGATAAACAT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	GCGATCGTATTTCCGATTGCGCGTTTGGAATTATTGAT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TTTTCTTACACTGCGGATTTTAATAAAGCCAAAGAGTTTGA
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TTTAGTTCTTCTCCCGCTACTGGAAGAGTCACTA
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT

>NZ_AP018280|2|2|2568478-2569103|CRISPRCasFinder
CTGATAGGGATTAGTTTGAATTGCAAT	CTAAAACCTAACGATATTATTGCAATCGATATCGGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	GTTTCTGTTCAAGTAAAGCTACTCTACTCGCATTTGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	TTTAAAAACCACGGTTAAGCGTAACCCTGGTGGTGCTGCCGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	TGAAAATGGCGTTGTTAATATTGGGAGATAAACATGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	TGTTAATTGTCAATGACGAATCATTAAAAGAATTAGAGATAAACATGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	GCGATCGTATTTCCGATTGCGCGTTTGGAATTATTGATGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	TTTTCTTACACTGCGGATTTTAATAAAGCCAAAGAGTTTGAGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT	TTTAGTTCTTCTCCCGCTACTGGAAGAGTCACTAGTTTCAATCC
CTGATAGGGATTAGTTTGAATTGCAAT

>NZ_AP018280|2|1|2568539-2569103|PILER-CR
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	GTTTCTGTTCAAGTAAAGCTACTCTACTCGCATTT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TTTAAAAACCACGGTTAAGCGTAACCCTGGTGGTGCTGCC
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TGAAAATGGCGTTGTTAATATTGGGAGATAAACAT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TGTTAATTGTCAATGACGAATCATTAAAAGAATTAGAGATAAACAT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	GCGATCGTATTTCCGATTGCGCGTTTGGAATTATTGAT
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TTTTCTTACACTGCGGATTTTAATAAAGCCAAAGAGTTTGA
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT	TTTAGTTCTTCTCCCGCTACTGGAAGAGTCACTA
GTTTCAATCCCTGATAGGGATTAGTTTGAATTGCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096616090.1\|2555393_2555996_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP018280.1\|WP_096616122.1\|2580802_2581438_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NZ_AP018280.1\|WP_096616110.1\|2574252_2574882_+\|ribonuclease-D	unknown	unknown	gnl\|CDD\|223426
NZ_AP018280.1\|WP_096616094.1\|2557703_2558135_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096616118.1\|2579360_2579675_-\|DUF1232-domain-containing-protein	unknown	unknown	gnl\|CDD\|225876
NZ_AP018280.1\|WP_096616120.1\|2579891_2580740_+\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|223881
NZ_AP018280.1\|WP_096616102.1\|2563962_2565360_+\|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	unknown	unknown	gnl\|CDD\|274962
NZ_AP018280.1\|WP_096616116.1\|2578258_2579053_-\|dTDP-glucose-pyrophosphorylase	unknown	unknown	gnl\|CDD\|133032
NZ_AP018280.1\|WP_096618479.1\|2573645_2574086_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP018280.1\|WP_096616098.1\|2560405_2561644_+\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_AP018280.1\|WP_096616112.1\|2575090_2575546_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_AP018280.1\|WP_096616114.1\|2575837_2577295_-\|alkaline-invertase	unknown	unknown	gnl\|CDD\|372373
NZ_AP018280.1\|WP_096616124.1\|2581966_2583697_-\|DUF814-domain-containing-protein	unknown	unknown	gnl\|CDD\|224212
NZ_AP018280.1\|WP_096616108.1\|2569473_2573196_+\|magnesium-chelatase-subunit-H	unknown	unknown	gnl\|CDD\|215643
NZ_AP018280.1\|WP_096616106.1\|2568083_2568311_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096616104.1\|2565373_2567983_+\|polynucleotide-kinase-phosphatase	unknown	unknown	gnl\|CDD\|274963
NZ_AP018280.1\|WP_096616096.1\|2558978_2559968_+\|transaldolase	unknown	unknown	gnl\|CDD\|183426
NZ_AP018280.1\|WP_096616100.1\|2562511_2563786_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_AP018280.1\|WP_096616092.1\|2556118_2557273_-\|NADH-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|224890
NZ_AP018280.1\|WP_096618478.1\|2561855_2562302_-\|peptidase	unknown	unknown	gnl\|CDD\|367843

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096616090.1\|2555393_2555996_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.32769e-14
NZ_AP018280.1\|WP_096616122.1\|2580802_2581438_+\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	3.4558e-20
NZ_AP018280.1\|WP_096616110.1\|2574252_2574882_+\|ribonuclease-D	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	2.88628e-74
NZ_AP018280.1\|WP_096616118.1\|2579360_2579675_-\|DUF1232-domain-containing-protein	gnl\|CDD\|225876	COG3339, COG3339, Uncharacterized conserved protein [Function unknown].	1.66117e-22
NZ_AP018280.1\|WP_096616120.1\|2579891_2580740_+\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	6.72776e-47
NZ_AP018280.1\|WP_096616102.1\|2563962_2565360_+\|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	gnl\|CDD\|274962	TIGR04074, Methyltransferase_type_12, 3' terminal RNA ribose 2'-O-methyltransferase Hen1. Members of this protein family are bacterial Hen1, a 3' terminal RNA ribose 2'-O-methyltransferase that acts in bacterial RNA repair. All members of the seed alignment belong to a cassette with the RNA repair enzyme polynucleotide kinase-phosphatase (Pnkp). Chemically similar Hen1 in eukaryotes acts instead on small regulatory RNAs. [Transcription, RNA processing, Protein synthesis, tRNA and rRNA base modification].	0
NZ_AP018280.1\|WP_096616116.1\|2578258_2579053_-\|dTDP-glucose-pyrophosphorylase	gnl\|CDD\|133032	cd04189, G1P_TT_long, G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase. This family is the long form of Glucose-1-phosphate thymidylyltransferase. Glucose-1-phosphate thymidylyltransferase catalyses the formation of dTDP-glucose, from dTTP and glucose 1-phosphate. It is the first enzyme in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme.There are two forms of Glucose-1-phosphate thymidylyltransferase in bacteria and archeae; short form and long form. The long form, which has an extra 50 amino acids c-terminal, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced.The long from enzymes also have a left-handed parallel helix domain at the c-terminus, whereas, th eshort form enzymes do not have this domain. The homotetrameric, feedback inhibited short form is found in numerous bacterial species that produce dTDP-L-rhamnose.	2.95423e-22
NZ_AP018280.1\|WP_096618479.1\|2573645_2574086_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	4.79857e-18
NZ_AP018280.1\|WP_096616098.1\|2560405_2561644_+\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_AP018280.1\|WP_096616112.1\|2575090_2575546_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.65042e-18
NZ_AP018280.1\|WP_096616114.1\|2575837_2577295_-\|alkaline-invertase	gnl\|CDD\|372373	pfam12899, Glyco_hydro_100, Alkaline and neutral invertase. This is a family of bacterial and plant alkaline and neutral invertases, EC:3.2.1.26, previously known as Invertase_neut pfam04853.	0
NZ_AP018280.1\|WP_096616124.1\|2581966_2583697_-\|DUF814-domain-containing-protein	gnl\|CDD\|224212	COG1293, COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription].	2.00567e-143
NZ_AP018280.1\|WP_096616108.1\|2569473_2573196_+\|magnesium-chelatase-subunit-H	gnl\|CDD\|215643	PLN03241, PLN03241, magnesium chelatase subunit H; Provisional.	0
NZ_AP018280.1\|WP_096616104.1\|2565373_2567983_+\|polynucleotide-kinase-phosphatase	gnl\|CDD\|274963	TIGR04075, Ser/Thr_phosphatase_family_protein, polynucleotide kinase-phosphatase. Members of this protein family are the bacterial polynucleotide kinase-phosphatase (Pnkp) whose genes occur paired with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1. All members of the seed alignment belong to a cassette with the Hen1. The pair acts in bacterial RNA repair. This enzyme performs end-healing reactions on broken RNA, preparing from the RNA ligase to close the break. The working hypothesis is that the combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring. [Transcription, RNA processing].	0
NZ_AP018280.1\|WP_096616096.1\|2558978_2559968_+\|transaldolase	gnl\|CDD\|183426	PRK12309, PRK12309, transaldolase.	0
NZ_AP018280.1\|WP_096616100.1\|2562511_2563786_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.36431e-25
NZ_AP018280.1\|WP_096616092.1\|2556118_2557273_-\|NADH-dependent-alcohol-dehydrogenase	gnl\|CDD\|224890	COG1979, COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion].	0
NZ_AP018280.1\|WP_096618478.1\|2561855_2562302_-\|peptidase	gnl\|CDD\|367843	pfam04151, PPC, Bacterial pre-peptidase C-terminal domain. This domain is normally found at the C-terminus of secreted bacterial peptidases. They are not present in the active peptidase. It is possible that they fulfill a similar role to the PKD (pfam00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C).	0.000256382

>NZ_AP018280.1|WP_096616106.1|2568083_2568311_-|hypothetical-protein
MNEIPKKVQSQQPRRNRPPIGGLGENPPSLGSQQIHSLTTLTVACYSTRSPSASTAEQYRIAKIETRDIPATKQL
>NZ_AP018280.1|WP_096616104.1|2565373_2567983_+|polynucleotide-kinase-phosphatase
MKLTIPELSLVVLIGASGSGKSTFARSNFQKFEVISSDFCRGLVSDDENSQAASHDAFEVLHYIAAKRLTTGKLTVIDATNVQPEDRKEYIKLAREYHFFPVAIVLNLPEEICHQRNSQRTDRQFGAHVVRRHSQALRRSLRGLEKEGFRYVYVLNSLDEINDIQIERQPLWNNRKYEKGPFDIIGDIHGCCDELELLLEKLGYQAHANTYSQKAEAKKEFWDFPIYSHPEGRKAVFLGDLVDRGSRILDTVKLVRNMVEAGTGICVPGNHEHKLLRKLRGKNVRITHGLEQTLTEIEAIPEDIRKSSIKELQEFLDSLVSHYVLDGGNLVVAHAGMKQEMQGRGSGAVREFALYGETTGEIDEFGLPVRSPWASKYRGDAMVVYGHTPVPEAEWLNNTIDIDTGCVFGGKLTALRYPEKELVSVDAARVYCEPIKPLGISANGMNRGSTLQHLEDDVLHIDDVLGKRIISTRLQNNIKIREENSIVALEVMSRFAANPKWLIYLPPTMSPVETSQIPGFLEYPQQAFAYYENAGITEVICEEKHMGSRVVVIVCRDEAAANKRFDVVGEGIGICYTRTGRKFFNNEALETELLTRVNTALTSSYFWETFNTDWVCLDCELMPWSAKAQGLLTKQYAPVGMSSRLALGDAVDLLAKAQQRGVEVSSQINSYQQRAEMASQYVEAYRRYCWNTKDIDDIKLAPFHILATEGAVHTDKSHQWHMEEIAKIASWDCNLLLTTQYKIINLTDPSSKAEATHWWEEITNAGGEGMVVKPMEFIIRGDRGILQPAVKCRGREYLRIIYGAEYTASENLSRLRQRGLSHKRSLAMREFALGVEALERFVKHQPLRKVHECVFGILALESEPVDPRL
>NZ_AP018280.1|WP_096616102.1|2563962_2565360_+|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1
MLLTITTTHEPATDLGYLLHKHPDKCQTFPLSFGKVHIFYPEASASKCTAALLLDIDPIKLVRGRSATLEQYVNDRPYVASSFLSVAMSQVLGSAMGGRCKEKPELAQTPIFLTAKISVVPCRGGEGILRELFEPLGYTVTAENHQLDEKFPEWGTSKYYTVELAHTLPLSELLSHLYVLIPVLDDEKHYWVGEDEIKKLLRHGEGWLNKHPAKEKIARRYLKRRGSLTRQALTQLAEADNLDPDAREVAHTEEELAIEKPLSLNKQRMLAVVETLKANNVKQVIDLGCGEGTLLRYLLKELCFGKITGVDVSYRALEIAKERIDKLHLPRHQWDKLQIFQGALTYQDKRFQNYDAITLIEVIEHLDLQRLHALERVIFEFSHPHLVIVTTPNIEYNIKFENLPAGKFRHKDHRFEWTRREFQDWANLVAEKFSYTVSFQTIGDNDLEVGSPTQMAVFNISQSGI
>NZ_AP018280.1|WP_096616100.1|2562511_2563786_-|tetratricopeptide-repeat-protein
MVEPNMSVLGDYEFWYNLGNEQFDLGLTEDAIASYEHAIAIKPDFAEAWFHLGNIFEEEEDTETAINYYEQAVTIKPNFYEVWHKYGNLLRNLERDDEAVICFDQALAVKPDAYIIWLERGHALRNLERYDEAIDSYNHIVNLQSQSIKTSFNYPWHWFHDAWRSQINLLSLRERYEEALAKCNQKLEVFPNDISNWYQRGDLLCKLKRYQEALENYEKVMQLHPGDYLAWHYRGDVLGYLGDVKSALASYDKSIEMYSGYYRTWYNRGCILYSLGQYQEALTNYNKTLDIYPEYEEAWCQRGLIMHYLGQYEAAIHSYQKALEICPNFIEALTNLGNTLHTLGRHQEAIENYHQAIELKPDDYQAWKNQGISQTALNLWEDALFSYNKAFEINPSDREIWKYRSDVLFVLKRHDEANKILKRL
>NZ_AP018280.1|WP_096618478.1|2561855_2562302_-|peptidase
MLKKLLNQSIITTIILITSQINVQAVTQNPSYHPIPLTMGKEIKDQLSKSDIPTGEGGFARDYIVNLTADDLIEIEVKSETFDPIVTLLSPKGITIEQNDDVGEGFTNSLMFARIPKTGNYTIRVRSFGNESVEGNFTLRMTRLRREQ
>NZ_AP018280.1|WP_096616098.1|2560405_2561644_+|acetate-kinase
MKILVLNAGSSSQKSCLYEISGDTLPQQPPKPLWEAKVDWSHHQGKAEIEITTAKGKSLQEEISTDSRVEVTAYLLNTLNQGSTQVINQLTEIDIVGHRVVHGGREYRESVFITEDVKNAIAHLANLAPEHNPANLEGIIAIEKHLGNIPQVAVFDTAFHSNIPDAAAIYPIPYELIEKGIRRYGFHGISHQYCANRAAQILGQDLASLRLITCHLGNGCSLAAIKNGRSIDTTMGFTPLDGLMMGSRSGAIDPGILIYLMQKENYTAEKLNHVLNKASGLSGISGISGDMRQIRHAISPENNTPTEIRDRAQLALDIYIHRLKSYIGAMIASLGGLDVLVFTAGVGENSPEVRKLACEGFNFLGVQLNHENNNRSLIDTEISTVNSAVRILVIHTQEDWQIACECWQKKGN
>NZ_AP018280.1|WP_096616096.1|2558978_2559968_+|transaldolase
MSNLLEQLRKMTVVVADTGDIGAIAKFTPRDATTNPSLITAAAQMPEYQEIVDQTLLTAKQDLGKNASQAEILSLAFDRLAVSFGLKILEIIPGRVSTEVDARLSYDTEATVKKAHELIAQYKAAGVDKERVLIKIATTWEGIRAAEILEKEGIHCNLTLLFGLHQAIACAEAGVTLISPFVGRILDWYKKETGRDSYPATEDPGVVSVTTIYNYYKKFGYKTEVMGASFRNIGEIIELAGSDLLTISPQLLGELQATIGELPRKLDPAKAASMSIEKITMDKATYDKMHAADKMANEKLDEGIKGFTKALESLEQLLAERLAKLEVLA
>NZ_AP018280.1|WP_096616094.1|2557703_2558135_+|hypothetical-protein
MKKAIRNLLLGLAILPFSVLAPNGNAQASLAVTQWFFGNWDCTIDGRPAKMQWRVVDDTQVNCNGDVCSSSSGVKVVGRFSDNGSAWVPLATRYSNRTDLGIRYLGREQDNWFLRFEPRGQSASGWTTWRGNRYPLMCRKLAR
>NZ_AP018280.1|WP_096616092.1|2556118_2557273_-|NADH-dependent-alcohol-dehydrogenase
MQNFTFHNPVKILFGKGQIANIAAEIPTDAKILMTYGGGSIKKNGVYEQVKSALSKHNLIEFGGIEPNPHYETLMKAVEIVKQEDINYLLAVGGGSVVDGTKFISVAVDFDGDPWDILSKAAPVKSAIPFGVVLTLAATGSEMNTAAVITKAANQEKRHFYSPLVFPQFSVLDPETTFSLPPRQVSNGIVDAFTHTMEQYLTYPVNAPLQDRMAEAILKTLVEEGPKTIANPSDYDSRANFMWCATMALNGIIAVGVPQDWSTHMIGHELTALHGLDHAQSLAVVLPSTLTVKRDNKWQKLLQYAERVWGIDQGSEEERVNAAIANTRAFFESVGTRTKLSDYGVGLDTIPLVIDRLKSYGYTALGEKQDVNPQTVEKILTLSA
>NZ_AP018280.1|WP_096616090.1|2555393_2555996_-|TetR/AcrR-family-transcriptional-regulator
MSKGEETKAMIIEKSAALFNQQGYAGSSMSDIMQVTGLQKGGIYNHFASKDDLALQAFDYAVSQIKQRFRDAWKDKHHAIERLQAIINVFRLYIDNPEHPIMKGGCPLLNTAVESDDAHPALKARAKQAMDSWCNLFGGIIRKGVKKGEIQPNINVDEVTSIIISTLEGSVMMSKLCDDSIHLERAIAHLNNYIDSSLKV
>NZ_AP018280.1|WP_096616108.1|2569473_2573196_+|magnesium-chelatase-subunit-H
MKYIVLIAGFESFNAELYRKAAELAVLRCSELDIQVFSDRDITVQPENVEKALQKADVFFGSLLFDYDQVMWLCDRVSQIPIRLVFESALELMALTKIGEFAIGDKPKGMPKPIKFILDKFSNGREEDKLAGYISFLKTGPKLLKFIPVQKVQDLRNWLIIYGYWNAGGIENVASLFWVLGEKYLKLKVGDIPAVVETPNIGLLHPDYQGYFESPRDYLQWYQENKLRGEEGGKIFNYPTIGILLYRKHVITKQPYIPQLIRKFENAGLIPLPIFINGVEGHVAVRDLMTTEYEIQQRQLGNTEIKSLSPTAVRVDAIVSTIGFPLVGGPAGSMEAGRQVEVAKRILTAKNVPYFVAAPLLIQDIHSWTRQGIGGLQSVVLYSLPELDGAIDTVPLGGLVGEDIYLVPERVNRLIGRVKSWINLRQKPVSERKIAVILYGFPPGYGATGTAALLNVPRSLIKFLQALKNQGYNIDDLPADGEALIRLVKDADEGIKVIDKHELMQESVVNTITSVNVRTLEKWLGYLQTNRIEKQWKSLTESGIKTSGDELQIGGITLGNVWIGVQPPLGIQGDPMRLMFERDMTPHPQYAAYYKWLQNEFKADAIMHFGMHGTVEWLPGSPLGNTGYSWSDILLGDLPNLYIYAANNPSESILAKRRGYGVLISHNVPPYGRAGLYKELVTLRELIAEYREDTEKNYVLKEVICKKIVDTGLDADCPFEESRKLGISFSPENIRMFSNHIFNDYLVKLYEYLQVLENRLFSSGLHVLGEVPNEEAMQSYLDAYFGEENIKNISVSEDNLKDNSQENEIRTLLMQNTDELTNLLRGLNGEYIPPAPGGDLLRDGAGVLPTGRNIHALDPYRMPSPAAYERGREIAQKIIQQHLKDHGKYPETVAVMLWGLDAIKTKGESLGILLELVGAEPIKEGTGRIVRYELKPLNEVGHPRIDVLANLSGIFRDSFVNIIELLDDLFQRVADADEPEEENFIRKHVLTLKAQGIENAAARLFSNPSGDFGSLVNDQVVDGNWESGDELANTWQSRNSFSFGRKDKGQSRPEILTTLLETTNEIIQEIDSVEYGLTDIQEYYANTGGLKKAAEKISAKKVNASFVESFSKDTTPRKLDDLLRMEYRSKLLNPKWAEAMANQGSGGAYEISQRMTALIGWGGTVDFRDDWVYEQASETYALDAAMADKLRQANPEAFRNIIGRMLEAQGRGFWNAGEDKLQKLRELYEMTDEQLEGVSV
>NZ_AP018280.1|WP_096618479.1|2573645_2574086_+|pentapeptide-repeat-containing-protein
MKSKLLTAVALVSTLSFAAPAFAEPEVNSNVRRLIETRECYACNLTGANLQGAHLIGADLRNANLQGANLKDANLEGADLTGANLQSANLTSAFINSVSLNNANMMNANLTNAQFISAELDGANLIGVNLAGAELFNVNLGIGGEY
>NZ_AP018280.1|WP_096616110.1|2574252_2574882_+|ribonuclease-D
MTLPDFQVSDRDINEETLSTYLQSDALAVDTETMGLLPQRDRLCLVQLCDNSGKVTVIRILRGQTEAPNLKKLLEASNVTKIFHFARFDIATLRYHLGIHVNPIFCTKIASKLARTYTNRHGLKDLILELEQVELDKSSQSSDWGNAINLTEAQLNYAANDVRYLISARQKLINMLKREERYELAEQCFQCLSAIATLDIMQFKDIFEH
>NZ_AP018280.1|WP_096616112.1|2575090_2575546_-|rhodanese-like-domain-containing-protein
MNNKLFDNIIPQEPPVHEHSDAHTVKARLEWGEPALTILDVRDRQSYNQCHIMGAMPAPMDELQHMAESSLHKKRDIYIYGANDEETDQAAKSLRDVGFSHVSSLRGGLEAWKAIGGSTEGTMESQSEPDAGAYNVVDRIKTHLETQQKEV
>NZ_AP018280.1|WP_096616114.1|2575837_2577295_-|alkaline-invertase
MQLEDFVTVKNIEAEAWEALEKSIVYYKGRPIGTVAAVDTSSEALNYDQVFVRDFVSSALIFLTKGRTEIVRNFLEETLKLQPKERQLDAYKAARGLMPASFKVVSVDGKEFLDADFGEHAIARVTPVDSCLWWIILLRAYVVATKDFCFAYRPEFQTGIKLILELCLANRFDMYPTLLVPDGACMIDRRMGIYGHPLEIQALFYAALRAARELLICDNNSGNQDIIAAIDNRLPLLCAHIRQHYWIDLNRLNTIYRFKGEEYGKMAVNLFNIYADSLPYYELDKWLPVKGGYLAGNVGPSQLDTRFFSLGNLMAIISELATEEQSQAIMNLIDERWDNLIGDMPMKICFPALEGEEYRIVTGCDPKNIPWSYHNGGSWPVLLWMLAAAAVKTNRTDLAKKALAIAQPRLQQDEWIEYYDGKKGRLIGKQSRKYQTWTIAGFLLAKELLENPQHLPLVSFEELPQELVSRACEFEISSVDTSLYF
>NZ_AP018280.1|WP_096616116.1|2578258_2579053_-|dTDP-glucose-pyrophosphorylase
MNQRKIIGLLPAGGQATRISPLPLSKELYPIGFQSLNNQTNSTNLHPKVVSHYLLEKMRLAGIETAYFILRPGKWDIPTYFGDGTMLSMNLGYLIMGLSYGVPFTLEQAYPFVRDAIVALGFPDIIFQPEDAFTKILARQVTTNADVVLGLFPTSTPQKAGMVDFDVSGKVNLVIEKPQHSQLKYMWAIAVWTPVFTEFLHEYIVMLQSKTNISQLPEIPIGNIIQAAIETGMHVEAEVFENGSYLDIGTPNDLIYAVNQYSNL
>NZ_AP018280.1|WP_096616118.1|2579360_2579675_-|DUF1232-domain-containing-protein
MKFSIEALYNWYRGLLRNPKYRWWVVLGTFLYFVSPIDIAPDFLPIVGQLDDVLILTLLVSEVSQIAIEGFKARRGTPESQTANASSQSTSQTESIDVDAVSVE
>NZ_AP018280.1|WP_096616120.1|2579891_2580740_+|MotA/TolQ/ExbB-proton-channel-family-protein
MDILAEFRKGGIAMYPLAVLSVLVVSVILERLWFWLRLLNQEKQIVTRVLEAAREDWTIARDIAQRAMDQPIGRFLFAPLNLPKADAETFRLALESSADHELSGMRRGDKLLEAAIALAPLLGLFGTVTGLIQSLRGIKIGDLVEPESIARVTGGIGESLYSTATGMVVAIVSLAFYRLFQAFIFNQVRIFQRAGNDLELLYRQSPPNYDLLRLSAETQNSERYSAANYPTEITPATTPNPTTSETTTTQDSFNYPRRRPQRNFGEPYEASTDNNSPDSENS
>NZ_AP018280.1|WP_096616122.1|2580802_2581438_+|biopolymer-transporter-ExbD
MKIKSTTPTDDVQVQIVPLIDVIFCILTFFILVTLQFSRQEVIKVINFDLPKSNTGTAIPGASNLPGSPAEPQRLVLHLDGLGQIRNTNQPGQPVITKEQLPAFLENYVKQNPDKPLILNASRSAQYNDVIETLTLLQQVGGSRASLGVADSSSSLQPTNPGFPSFPGTVPPENNPQLPPVNPQGGTIPNVPTNQIPEPGKPAATTVPPQQ
>NZ_AP018280.1|WP_096616124.1|2581966_2583697_-|DUF814-domain-containing-protein
MQSFDFTTLTAVCSELRQSFLPSRLEQVYQRDRATISIALRTLQGRGWLEISWHPQAARLHIGDAPPRTPDTFTFSQQLLSQLGGLALVEIATTSPWERVVDLQFARRPGEDALYHVYVEIMGKYSNVVLTNAKNEIITTAHQVNQQQSSIRTVLTGQLYESPPRMTNTIPSLEESWQRWQERVGLVPGALKKQLLKNYRGTSPALIQSMLKAANLDLEVNTDSLSVEEWQNLFVYWQSWLRCLEKHQFEPVFLESGYSVLGWGGIEKATNTQQLVNSYYTNQFNQLVFSQLQHQLSQKLNNILEKLRQKANTFTEKLQQSDRADEYRQKADLLMAHLHTWEPGMKEMRLADFETGEPVTVTLEPDKNAVVNAQILYKKHQKLKRARAAVEPLLAEVNIEIEYLEQVEAAITQIETYQTAEDLQALEEIRDELVSQKYIEDTGYKSRDRDEPTFHFRRDRTPSGFEILIGRNNRQNDQLTFRVASDYDLWFHTQEIPGSHVLLRLPAGKIPEESDLQYTANITAYYSRARQSEQVPVVYTQLKHVYKPKGAKPGIAIYKNERVLWGQPQLARMKLV

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Crispr_ID: NZ_AP018280_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_3

3204371-3205120

Orphan

I-D,II-B

Consensus_repeat	Method
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	CRISPRCasFinder
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	CRT
GTTTC----------AATCCCTGATAGGGATTATTTTGAATTGCAA	PILER-CR

10 spacers

The CRISPR arrays of NZ_AP018280_3

>merge|NZ_AP018280|3|3204371-3205120|CRISPRCasFinder,CRT,PILER-CR
ACTGTATTGCCTAATAGGGATTATTTTGAATTGCAATCCTTCCAGCGCTTGTTACTTTTACAAGTTTCCCCGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAGTTGAACCTGTTGATAAATTCAATCAAATGTTTAGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATTTTCCCTAGGTGTTTTTGATGCCGTATCCTGCTTACGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATGCGAATTTCCGCTTCCTGTGCTGCCAATTCCCCTGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATGGAGAACCAGAAAAAACAATCATCAGTTTCTACGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATTTCATGCACTACAGCCAACTGAGGATTTCTGCCTATGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATCCTTCGTCTGATTGCACTACCCAGCTACCATCTAGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAAAAGTAATTACGAGTAAATAAAGGATAGAAAAATGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATTGACGAAATTTCCTATTTTCAAATAACAAAAGATGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAATTCACCTAAATAAATAGTCGCGTGTTTTCGGGAAATAGTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT

>NZ_AP018280|3|3|3204371-3205120|CRISPRCasFinder
ACTGTATTGCCTAATAGGGATTATTTTGAATTGCAAT	CCTTCCAGCGCTTGTTACTTTTACAAGTTTCCCC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAG	TTGAACCTGTTGATAAATTCAATCAAATGTTTA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TTTCCCTAGGTGTTTTTGATGCCGTATCCTGCTTAC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	GCGAATTTCCGCTTCCTGTGCTGCCAATTCCCCT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	GGAGAACCAGAAAAAACAATCATCAGTTTCTAC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TTCATGCACTACAGCCAACTGAGGATTTCTGCCTAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	CCTTCGTCTGATTGCACTACCCAGCTACCATCTA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAA	AAGTAATTACGAGTAAATAAAGGATAGAAAAAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TGACGAAATTTCCTATTTTCAAATAACAAAAGAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TCACCTAAATAAATAGTCGCGTGTTTTCGGGAAATA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT

>NZ_AP018280|3|2|3204371-3205120|CRT
ACTGTATTGCCTAATAGGGATTATTTTGAATTGCAAT	CCTTCCAGCGCTTGTTACTTTTACAAGTTTCCCC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAG	TTGAACCTGTTGATAAATTCAATCAAATGTTTA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TTTCCCTAGGTGTTTTTGATGCCGTATCCTGCTTAC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	GCGAATTTCCGCTTCCTGTGCTGCCAATTCCCCT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	GGAGAACCAGAAAAAACAATCATCAGTTTCTAC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TTCATGCACTACAGCCAACTGAGGATTTCTGCCTAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	CCTTCGTCTGATTGCACTACCCAGCTACCATCTA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAA	AAGTAATTACGAGTAAATAAAGGATAGAAAAAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TGACGAAATTTCCTATTTTCAAATAACAAAAGAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT	TCACCTAAATAAATAGTCGCGTGTTTTCGGGAAATA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAAT

>NZ_AP018280|3|2|3204442-3205119|PILER-CR
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	GTTGAACCTGTTGATAAATTCAATCAAATGTTTA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TTTTCCCTAGGTGTTTTTGATGCCGTATCCTGCTTAC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TGCGAATTTCCGCTTCCTGTGCTGCCAATTCCCCT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TGGAGAACCAGAAAAAACAATCATCAGTTTCTAC
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TTTCATGCACTACAGCCAACTGAGGATTTCTGCCTAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TCCTTCGTCTGATTGCACTACCCAGCTACCATCTA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	AAAGTAATTACGAGTAAATAAAGGATAGAAAAAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TTGACGAAATTTCCTATTTTCAAATAACAAAAGAT
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA	TTCACCTAAATAAATAGTCGCGTGTTTTCGGGAAATA
GTTTCAATCCCTGATAGGGATTATTTTGAATTGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096617093.1\|3209644_3210409_-\|pyruvate-formate-lyase-activating-protein	unknown	unknown	gnl\|CDD\|131546
NZ_AP018280.1\|WP_096617081.1\|3202534_3203125_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NZ_AP018280.1\|WP_096617101.1\|3215033_3216572_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_AP018280.1\|WP_096617099.1\|3213795_3215010_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225459
NZ_AP018280.1\|WP_096617089.1\|3209052_3209283_+\|addiction-module-killer-protein	unknown	unknown	gnl\|CDD\|162974
NZ_AP018280.1\|WP_096617095.1\|3210422_3212468_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NZ_AP018280.1\|WP_096617085.1\|3205937_3206369_-\|DUF2262-domain-containing-protein	unknown	unknown	gnl\|CDD\|226746
NZ_AP018280.1\|WP_096617087.1\|3206839_3208813_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_AP018280.1\|WP_096617091.1\|3209254_3209554_+\|transcriptional-regulator	unknown	unknown	unknown
NZ_AP018280.1\|WP_096617097.1\|3212662_3213700_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270690
NZ_AP018280.1\|WP_096618508.1\|3203253_3203919_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP018280.1\|WP_096617075.1\|3196255_3196504_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375096
NZ_AP018280.1\|WP_096617083.1\|3205461_3205839_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096617077.1\|3196633_3197539_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|215254
NZ_AP018280.1\|WP_096617079.1\|3199748_3202484_+\|choice-of-anchor-D-domain	unknown	unknown	gnl\|CDD\|380152
NZ_AP018280.1\|WP_096617073.1\|3195489_3196188_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_AP018280.1\|WP_096618507.1\|3197705_3199136_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235798
NZ_AP018280.1\|WP_096617067.1\|3192497_3192695_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096617069.1\|3192693_3194046_+\|low-complexity-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP018280.1\|WP_096617071.1\|3194148_3195279_+\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|273528

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096617093.1\|3209644_3210409_-\|pyruvate-formate-lyase-activating-protein	gnl\|CDD\|131546	TIGR02493, PFLA, pyruvate formate-lyase 1-activating enzyme. An iron-sulfur protein with a radical-SAM domain (pfam04055). A single glycine residue in EC 2.3.1.54, formate C-acetyltransferase (formate-pyruvate lyase), is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter. The reaction requires Fe2+. The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5-yl radical, which then abstracts a hydrogen radical from the glycine residue. [Energy metabolism, Anaerobic, Protein fate, Protein modification and repair].	1.66196e-118
NZ_AP018280.1\|WP_096617081.1\|3202534_3203125_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	3.76953e-43
NZ_AP018280.1\|WP_096617101.1\|3215033_3216572_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	3.28665e-43
NZ_AP018280.1\|WP_096617099.1\|3213795_3215010_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|225459	COG2907, COG2907, Predicted NAD/FAD-binding protein [General function prediction only].	9.91172e-42
NZ_AP018280.1\|WP_096617089.1\|3209052_3209283_+\|addiction-module-killer-protein	gnl\|CDD\|162974	TIGR02683, Uncharacterized_protein_HI_1419, putative addiction module killer protein. Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.	2.24896e-28
NZ_AP018280.1\|WP_096617095.1\|3210422_3212468_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_AP018280.1\|WP_096617085.1\|3205937_3206369_-\|DUF2262-domain-containing-protein	gnl\|CDD\|226746	COG4296, COG4296, Uncharacterized protein conserved in bacteria [Function unknown].	6.88967e-19
NZ_AP018280.1\|WP_096617087.1\|3206839_3208813_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_AP018280.1\|WP_096617097.1\|3212662_3213700_-\|hypothetical-protein	gnl\|CDD\|270690	cd05120, APH_ChoK_like, Aminoglycoside 3'-phosphotransferase and Choline Kinase family. This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	0.000614688
NZ_AP018280.1\|WP_096617075.1\|3196255_3196504_-\|hypothetical-protein	gnl\|CDD\|375096	pfam17275, DUF5340, Family of unknown function (DUF5340). This family of unknown function can be found in Cyanobacteria.	3.74818e-36
NZ_AP018280.1\|WP_096618508.1\|3203253_3203919_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	8.96203e-22
NZ_AP018280.1\|WP_096617077.1\|3196633_3197539_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|215254	PLN02460, PLN02460, indole-3-glycerol-phosphate synthase.	6.46605e-138
NZ_AP018280.1\|WP_096617079.1\|3199748_3202484_+\|choice-of-anchor-D-domain	gnl\|CDD\|380152	NF012200, choice_anch_D, choice-of-anchor D domain-containing protein. This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.	2.39668e-10
NZ_AP018280.1\|WP_096617073.1\|3195489_3196188_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	4.86273e-34
NZ_AP018280.1\|WP_096618507.1\|3197705_3199136_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_AP018280.1\|WP_096617069.1\|3192693_3194046_+\|low-complexity-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.49072e-21
NZ_AP018280.1\|WP_096617071.1\|3194148_3195279_+\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	1.368e-100

>NZ_AP018280.1|WP_096618508.1|3203253_3203919_-|tetratricopeptide-repeat-protein
MQIKSQLKSVFTIHFYYLILGILSVSLASPSVLANSTSSNQTTLSSGILIAQLSENEQTERRQLIQTANSQMQSGNLAGAEESLRQLVKKFPKDAFGHYQLGNVLLRQEKPENAIASFQEATRLNPRYALAYNGMGISYASQEKWDDAITQFRKALEINPEYGDALMFLGQVLLQVNKRDEGVASLNKALNIFKQQNRNERVKRIENILRKLKPTDDPSIS
>NZ_AP018280.1|WP_096617081.1|3202534_3203125_+|Uma2-family-endonuclease
MVTSCSKNYFSPEEYLEGEKYSQIKHEYVDGEVYAMSGASDAHVTISLNAAMLLRNHHRGSGCRVYVADMKVQIKTCDINRYYYPDVMVTCDGRDKESEYFKAYPCLIIEVLSDTTEAIDRGKRFKDYRRLASLQEYVIISQKIMDVEVFRRNEKGGWELSAFEAGELVEFASVNFCCDISEFYEDVDLDTRNFIA
>NZ_AP018280.1|WP_096617079.1|3199748_3202484_+|choice-of-anchor-D-domain
MTQQQIVELAKQGDINAIEALINELLKPQGITAKVRFKDSCLYVALVAAKVPEKKALVRIICQQIIQWRVKSLNYAKIYAAQWGNNLPVWQQEVHLYKLRPKKVINKSVQLTTLTIGDKALRKNSKYNNCQSSESLDNSSEIVGNYLTLGKLSIQINSTFGSILSIATQKYQIQSRLSHTSKELSSPRFPYLIGRLKEIKSAIHALNSSDISPESKKSIEFYGDTGLGKSALLRYLNSFIQGKRVFTDGTIFFNSHYQTVSDILQSLFDILYSSDIAYKPTDLEISQAVDGKKILIILDDKNLTAAEIKQLQTALPNCPLVLASTSKRLDETCFTSQLSGITTRDALTFVTQELERTVNPDDFQAIEALANLLAGNPWLLRLAVTSINQEIYTLGELVLKLQPPATNHVLIAGILAAIPKSDREILLILAAMNGVPLLATQVEALSGFSTTPLILQNLAKWHLVTIEQERYYINDILIRVLEKDNNLTSWREIILNYFTTWAEKYQSLPSLLHSETDVFMEILSWGVKAKNWHQVLRLVQAIESSLALSKQWGLWEKVLKLGLQAALALNDKSAEAFMLHQLGSRALCLEDMAAARNYLTHALKIRKSLENENAVNITQQNLNLISVILSKFDADTTKLTLNLIANNSISANTKIQLSTVTLISLFCVGCTGFMAWLVLLRPKLLPIAQTNSQNLPAKSDEIDLTQIIFTHSKLNFGKQAVNTESKRQTVTIANQSSMSVQIGNIQKDGEQGDFDVSNSCVTTISPNQSCNISVAFVPIDTGKHSASLAVSDRNGKILKMLLIEGFATTAQETSDNLVPAPPQVKQEPLPLPQPKLIPQSPLPKSPKRIIPQFPVAAPIPESSESPEATMPTESESPQPGVTESPQPEATDTTLPTPTEEIPAVIEAPTTP
>NZ_AP018280.1|WP_096618507.1|3197705_3199136_-|dihydrolipoyl-dehydrogenase
MSLGFDYDLIIIGAGVGGHGAALHAVGCGLKTAIIEAADMGGTCVNRGCVPSKALLAASGKVRELRNAHHLKSLGIQIGNVQFEREAIANHANNLAAKIQGDLTNSLKRLGVDIIRGWGKIAGTQKVSIITDAGEKTITAKDIIIAPGSVPFVPPGIEVDGKTVFTSDQGVKLETLPHWVAIIGSGYIGLEFSDVYSALGCEITMIEALDQLMPGFDRDIAKLAERTLITPRDIETYVGIYAKRVIPGSPVVIELANFKTKEDVETIEVDACLVATGRIPATKDLGLETVGVECDRRNFIPVNGSMAVLSNGEVVPHLWAIGDATGKMMLAHAASAQGIVAVENICGRSKVVDYDSIPAAAFTHPEISYVGRTEAQARELAKESGFEIGVAKSYYKGNSKALAEGEADGIAKVIYRQDTGELLGVHIFGLHASDLIHEASAAMANRQSVHTLAHLVHAHPTLSEVLDEAYKRAVGV
>NZ_AP018280.1|WP_096617077.1|3196633_3197539_-|indole-3-glycerol-phosphate-synthase-TrpC
MQIRRRNPNPAIDVSIIRYQTALENTEPNNILEEIVWHKEAEVAQMREKLPLHELQKQAMTAPPTRDFLAALRHGKTNPALIAEVKKASPSKGVIRADFDPVEIAQVYESAGATCLSVLTDQKFFQGSFNNLEKVRNAVDLPLLCKEFVIYPYQMYLARTKGADAVLLIAAILSDQDLQYFVKIANSLKMTPLIEVHSLEELDRVLALDGVSLVGINNRNLEDFSVDLQTTCKLLAQRQKALEERNILVVSESGLHTANDLNTVTTAGAAAVLIGESIVKQADIKAAVINLFAKTSLPSNY
>NZ_AP018280.1|WP_096617075.1|3196255_3196504_-|hypothetical-protein
MEQIPLPSPIHYELLLQMLERQTMSAVSQNPALRQQVNQLIITLRKAAVQQKHLEQACQFSAIEIDHRWSLNHHIGKVAAPD
>NZ_AP018280.1|WP_096617073.1|3195489_3196188_+|HAD-family-hydrolase
MLRIITDFDGPIVDVSERYYRVYQLCLEKARQPQQQVKVLGKKEFWQMKRDRIAETEIGILSGLNEEQALEFSKLRKQTVHTQPYFEYDVLAEGAIETLSKIQHLHVDLAVMTMRRVRELDYAFTKYDLGKFFLENRRYCLANDYVKTRDIEDKPLLMQRALAELPPATDTWMIGDTEADIAAAKRHNIKVIAVECGIRDRIKLVDYQPDLIVKNFSVAVDIILDNWQQQAG
>NZ_AP018280.1|WP_096617071.1|3194148_3195279_+|4-hydroxyphenylpyruvate-dioxygenase
MRIEHVHFYVEDAKTWRNWFVNILGFEVVENYILPSFPLNNTQKQEFHTLTEVVKSNSICFVISSPLLPTSPVAEFLHHHPPGVADVALIIEDMEEVMMRVESYGTEVLQPICEYQQNGIDFKSCQIKAWGSLAHTLIEIREIGNRGCGDVGILPLSALPCLDIPPSFPASLPLLTSIDHVVLNVPTGDLEKAVAWYEKILDLQPQQIFNIQTEFSALHSRVMTSRNGKVQLPINQPITPNSQIQEFLDFNQGAGIQHIALRSPNLVNTIANFRDRCLPFLSIPDAYYSQLVKRPGFSLSNSEIKAIAQQQILVDWKEQEPDALLLQIFTQPIFGKPTFFFEFIERRHLAQGFGEGNFRALFEAIESEQMKRGSLH
>NZ_AP018280.1|WP_096617069.1|3192693_3194046_+|low-complexity-protein
MTIESNSNPSQQPQNEANLEDNLQPDDFDGGDNGFKPDELAAQQALAAISSLQSSKHTTALKQARSTFKTHLPNTAIAKPRALLITLMAIALIFIGMATNTWIIGAFGTLVTLVLSIAMLLPWLQEVVKEWISPQERTVIFGIFGFLVALVGVIRFTGIGDDILQWGRRVNWDASGTLAEWFGALGQILIAIIAVYVAWRQYVISKDLTIQQNLLTVQQNIITQQQTIDSYFQGVSDLVLDEEGLLEDWPQERAIAEGRTAAILSSVDGSGKAKILRFLSRSKLLTPLKRDRHLGRAILDGSGGYAEDRIAGLRVIDLGVMLAGCDLANTDLRWTDLSEANLVRANLNNCDLVKANLSRTILYEANLSHTDLNSTRFFYGSVETASPRSRTEAPNYKTGEHTGAVIEDADFTNAQRMSESVRYYCCAWCGENKRSTIPGGCEGIPNKLGR
>NZ_AP018280.1|WP_096617067.1|3192497_3192695_-|hypothetical-protein
MLNIFAQMTQFNRCFIVAATGWGSASVIEEDGEIAREFKSGIYFFFSTNVACFPHQGMITWAKSN
>NZ_AP018280.1|WP_096617083.1|3205461_3205839_-|hypothetical-protein
MWKHKFSLVSFLFLLILSTVTSICFSPRALAKNPSFDANNVEPWQVNQNRLRNWNLQELQRNQNQQQHQWQDFNRKLQEQRDRQWQNNKRQWQEYNWKLQQRDRTTPNPEYQWPNNNPQWENYHQ
>NZ_AP018280.1|WP_096617085.1|3205937_3206369_-|DUF2262-domain-containing-protein
MTEQTIYDEILGELAWDDDDECWSSQVQFTLEHIVNVTIDPDDAETGAVIMKSRQSFAKLQENELNIRRLISDQMLKIYNDNWNNGEIIDTQDFIDSIKLEDIVFYANGNIQLFYNDGYLFAGHGIIVSIDEYGNYQEAVLFG
>NZ_AP018280.1|WP_096617087.1|3206839_3208813_-|acetate--CoA-ligase
MSESTIESILQEKRVFPPSVEFAQKAQVKSLADYETLYNKAKANPEAFWAELAETELHWFQKWDTTLDWTNPPFAKWFVNGKINISYNCIDRHLTTWRKNKAAIIWEGEPGDSRTITYAQLHREVCQFANVLKNLGVKKGDTVGVYMPMIPEAAIAMLACARIGAVHSVVFGGFSAEALRDRLNDGKAKLVITADGGWRKDAIVPLKPQVDKALADGACPSVTNVLVIKRTAQDVTMETGRDYWWHELQVKASPDCPPEPMDSEDMLFILYTSGSTGKPKGVVHTTGGYNLYSHMTTKWIFDLQDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGAPRASNPGCFWDVIEKYGVNIFYTAPTAIRAFIKMGDQHPNARNLSSLRLLGTVGEPINPEAWMWYHKVIGGEKCPIVDTWWQTETGGIMITPLPGAIPTKPGSATRPFPGILADIVDLDGNSVPDNQGGYLAVKYPWPGMMRTVYGDAERFRRTYWEHIPPKDGKYTYFAGDGARKDEDGYFWVMGRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTYTGSDELSKELKQHVVQEIGAIARPGEIRFTDALPKTRSGKIMRRLLRNLAAGEEVSGDTSTLEDRTVLDKLREGA
>NZ_AP018280.1|WP_096617089.1|3209052_3209283_+|addiction-module-killer-protein
MQARVKTGNLRDYKSVGDGVYELRINFAGGYRVYFGQIGTKIILLLCSGIKKTQDEDIETAKECWRDYERRENTNR
>NZ_AP018280.1|WP_096617091.1|3209254_3209554_+|transcriptional-regulator
MKDVKIPTGRSYREHLIESLKDSEHAAAYIAVILELDEEGYNPDILRSALAEVVEARKQLGNFSEVGQLCFQKLDNMLAETGGKEILALIEKMSCLCKQ
>NZ_AP018280.1|WP_096617093.1|3209644_3210409_-|pyruvate-formate-lyase-activating-protein
MFHQTPQVTTSTTTFGYIHSVETCGTVDGPGIRFVIFTTGCPLRCLYCSNPDCRYLENGKKVSVDELIAEIQKYTSYMKASGGGVTISGGEPLYQPEFIREIFRRCQELGIHTALDTSGFCNLEIAKPVFEFVDLVLLDIKSFDSATYTKVTGVDIEPTLIIAKYLSEIKKPTWIRFVLVPGLTNEVENIQGLADFVAQLDNVERLDVLPFHKMGEYKWEELGYQYKLKETPTPTSEEVEQVLVIFRNKGIRAF
>NZ_AP018280.1|WP_096617095.1|3210422_3212468_-|elongation-factor-G
MIPRSNIRNIGISAHIDAGKTTLSERILYYTGKIHKIAEVGSEGDGATMDYMELEREKGITITSAAVTCFWDGTQINLIDTPGHVDFTIEVERSLRILDGAIMVLCGVAGVQSQSITVDRQMKRYQVPRIAFINKLDRVGANPFRVVDALREKLGLNPVVLQYPIGLEDGFEGVIDLIEMTAHYFEGENGENWLKKPIPEALQAAAQVARDKLLDQISIHSEVMMAKLIAGEEIPPQLIWDAIRQGTLCLEFTPVLMGSAFKNKAVQNLLDAIALYLPSPVERSAITAIDVATNEPVQIYPEPDNPVVAIAFKLIDDEFGQLTYTRLYSGILHQGDKLYNSRTQKQVRVHRLVRIEVDKRQELEFATAGEIVGLVGVNCASGDTLCSPGTNLSLEGIFVPEPVMTIAITPKSQVDVDRISKALHRFAAEDPTLHVSIDPESHKTLISGMGELHLEIYLERMKREYHAEVYVSPPAVAYRETITQPAQFDFTLKKQTGGAGQYAHIKGSLQPCEDSFVFENQVVGGVIPKQFIAACEQGFKDALKTGWLKGYPIMGVKVILEGGSYHPIDSSEMAFRFAAKQGFEAAFAKAKPTILEPMMLLEVETPSQFLGRIQGKLLSRRALLLGSETRNNDVVIRAEVPLAEMFGYSTEVRSLSQGMATFSMEFAEYRQLPDNLLTAIK
>NZ_AP018280.1|WP_096617097.1|3212662_3213700_-|hypothetical-protein
MIGNNGIRIIVTMNNPSKLLWEEPIWSAKASSWIDNQLSQQNINRIGAIAQVRIRHWSTILRISTNLADIYFKAVIPELAYEAALTEILSHWYPHCMPQILAISRENGWLLMGDGGISLNESLKTENDIQHWQHILPIYAQLQKHAIAHLDQLLALGICGRRLEMLPHLYAELLANTELLAINHPEGITVSEYQSLQNSAGLFTSLCEQLAAFAIPETIHHGDLHDGNIFIKNGSYIFLDWGDSSISHPFFSIRDIYANLNRRFGLGKKSVWFQRLKDDYLSAWTEYETREKLEFAFELSQKISPIPDICRWIPVLSNMDAVTRDNYIDAIPKRLREFLKNLQQI
>NZ_AP018280.1|WP_096617099.1|3213795_3215010_-|FAD-dependent-oxidoreductase
MKLAIIGGGASGMVTAYLLNKNGHHVTVFEKQPILGGHIRTLNQNVQPNHSNCEEILENGVLEFPVKFHNFLHLMAELGVELEPVNIGSGLFLKDGSHFLSGVAIQKNFTGIQRLLEYLRLDTLYARSAGLWLQVKFSRMQDFYNQPMSAYLKRECIRNCWLKLSTMYSYSMAFELIDNLPAELAIPALKDYVFTSWVRIKGGVYSYIEKILERFQGDIVLNAEITNISRTGEQVKINLADGTTDIFDKVVFATPPDQVIKLLSDPTDAEIKRFSGWKENHIHTFLHTDTSMYRRYGIKNFSEFDFFQTQNGWGYNAYLNQLCGVASPPAYSLAFNLESLIAKDKILHIQQHHTPLYTVESFRYRDEIVATNGENNTYHAGAYLGDGLHEGAVTSAIRVAQLIG
>NZ_AP018280.1|WP_096617101.1|3215033_3216572_-|NAD(P)/FAD-dependent-oxidoreductase
MKTDYLIVGSGLSALVFGALMAKSGKKVQILEAHEYPGGFGHTFTLAKKYKFNAQLHYVWDCGEGYTVNRVLKHLGLDKEVTFERYSPDGFDHMRMPGYSLDIPSEPEKLIQRLSTLFPEHTNNIQRFISEVQKISQGLKILSPPIISTELFKHFGVALRTLMYLNSTLQDVFDKFKLPQAAQTLLALQWVDFLLPPNQLSFYAWVILFTGYQKGAFYPTKHFEHVINSLVKVITENNGEVLLNHEVTNFIVTEKTVNGVIATDKITHQSHEFTGDTIICNIDPKKAAQMIGMKKFSRTVRNKLDYDYSPSNYMAYCVVKDIDLRDYGFGKWNTFHIENHDLNQTFAQMYEKNDFSHPSFAITTPTLLTSEERDCPEDCQIIEFLTVANYNYFNNLQQRDKKAYRQKKDEIFESIIDIVEKYYIPNFRKHLVFKVTGSPTTNERFCWCPNGNSYGSNLTPKNMGIGRLNHQTSLNHFYFCNASSGYPGFAPTFWTGANLYQKLSGDMILAKG

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Crispr_ID: NZ_AP018280_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_4

3429982-3430107

Orphan

Consensus_repeat	Method
GATTTTGTGCGATCGCACTTTCACCAAGAGAAATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_4

>merge|NZ_AP018280|4|3429982-3430107|CRISPRCasFinder
GATTTTGTGCGATCGCACTTTCACCAAGAGAAATGCGATCGCTTGATTTTAGGTTTTTGTGGGGAGAAACCCGATTTTTTGAGATTTGCGGATTTTGTGCGATCGTACTTTCACCAAGAGAAATGC

>NZ_AP018280|4|4|3429982-3430107|CRISPRCasFinder
GATTTTGTGCGATCGCACTTTCACCAAGAGAAATGC	GATCGCTTGATTTTAGGTTTTTGTGGGGAGAAACCCGATTTTTTGAGATTTGCG
GATTTTGTGCGATCGTACTTTCACCAAGAGAAATGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096617372.1\|3417933_3418251_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_010997613.1\|3435441_3435687_-\|photosystem-I-iron-sulfur-center-protein-PsaC	unknown	unknown	gnl\|CDD\|177005
NZ_AP018280.1\|WP_096617378.1\|3421040_3422720_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096617370.1\|3416920_3417901_+\|replication-protein	unknown	unknown	gnl\|CDD\|366647
NZ_AP018280.1\|WP_096617380.1\|3423312_3424659_+\|KAP-family-P-loop-domain-containing-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096617374.1\|3418618_3420061_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|100093
NZ_AP018280.1\|WP_096617364.1\|3413866_3414409_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NZ_AP018280.1\|WP_096617390.1\|3442985_3443912_-\|DUF11-domain-containing-protein	unknown	unknown	gnl\|CDD\|307488
NZ_AP018280.1\|WP_096617376.1\|3420328_3420922_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_AP018280.1\|WP_096617400.1\|3449421_3449973_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_AP018280.1\|WP_096617368.1\|3416383_3416680_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096617366.1\|3414641_3416159_-\|NADH:ubiquinone-oxidoreductase	unknown	unknown	gnl\|CDD\|369941
NZ_AP018280.1\|WP_096617396.1\|3447294_3447927_+\|exopolysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226442
NZ_AP018280.1\|WP_096617398.1\|3448493_3449273_-\|photosystem-II-S4-domain-protein	unknown	unknown	gnl\|CDD\|132113
NZ_AP018280.1\|WP_096617392.1\|3444852_3445920_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223512
NZ_AP018280.1\|WP_096617388.1\|3435966_3438723_-\|DUF11-domain-containing-protein	unknown	unknown	gnl\|CDD\|273634
NZ_AP018280.1\|WP_096617394.1\|3446218_3447100_+\|lipid-kinase	unknown	unknown	gnl\|CDD\|183857
NZ_AP018280.1\|WP_096617386.1\|3433248_3435126_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_AP018280.1\|WP_096617384.1\|3430455_3433275_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NZ_AP018280.1\|WP_096617382.1\|3424809_3429909_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_010997613.1\|3435441_3435687_-\|photosystem-I-iron-sulfur-center-protein-PsaC	gnl\|CDD\|177005	CHL00065, psaC, photosystem I subunit VII.	8.5993e-53
NZ_AP018280.1\|WP_096617370.1\|3416920_3417901_+\|replication-protein	gnl\|CDD\|366647	pfam01446, Rep_1, Replication protein. Replication proteins (rep) are involved in plasmid replication. The Rep protein binds to the plasmid DNA and nicks it at the double strand origin (dso) of replication. The 3'-hydroxyl end created is extended by the host DNA replicase, and the 5' end is displaced during synthesis. At the end of one replication round, Rep introduces a second single stranded break at the dso and ligates the ssDNA extremities generating one double-stranded plasmid and one circular ssDNA form. Complementary strand synthesis of the circular ssDNA is usually initiated at the single-stranded origin by the host RNA polymerase.	2.19244e-112
NZ_AP018280.1\|WP_096617374.1\|3418618_3420061_+\|phosphoglucosamine-mutase	gnl\|CDD\|100093	cd05800, PGM_like2, This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.	0
NZ_AP018280.1\|WP_096617364.1\|3413866_3414409_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	1.11509e-44
NZ_AP018280.1\|WP_096617390.1\|3442985_3443912_-\|DUF11-domain-containing-protein	gnl\|CDD\|307488	pfam01345, DUF11, Domain of unknown function DUF11. A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond.	6.79963e-13
NZ_AP018280.1\|WP_096617376.1\|3420328_3420922_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	4.70968e-43
NZ_AP018280.1\|WP_096617400.1\|3449421_3449973_-\|N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.37337e-20
NZ_AP018280.1\|WP_096617366.1\|3414641_3416159_-\|NADH:ubiquinone-oxidoreductase	gnl\|CDD\|369941	pfam08547, CIA30, Complex I intermediate-associated protein 30 (CIA30). This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation.	2.67031e-60
NZ_AP018280.1\|WP_096617396.1\|3447294_3447927_+\|exopolysaccharide-biosynthesis-protein	gnl\|CDD\|226442	COG3932, COG3932, Uncharacterized ABC-type transport system, permease components [General function prediction only].	1.61044e-68
NZ_AP018280.1\|WP_096617398.1\|3448493_3449273_-\|photosystem-II-S4-domain-protein	gnl\|CDD\|132113	TIGR03069, RNA-binding_S4_domain-containing_protein, photosystem II S4 domain protein. Members of this protein family are about 265 residues long and each contains an S4 RNA-binding domain of about 48 residues. The member from the Cyanobacterium, Synechocystis sp. PCC 6803, was detected as a novel polypeptide in a highly purified preparation of active photosystem II (Kashino, et al., 2002). The phylogenetic distribution, including Cyanobacteria and Arabidopsis, supports a role in photosystem II, although the high bit score cutoffs for this model reflect similar sequences in non-photosynthetic organisms such as Carboxydothermus hydrogenoformans, a Gram-positive bacterium. [Energy metabolism, Photosynthesis].	4.57741e-138
NZ_AP018280.1\|WP_096617392.1\|3444852_3445920_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	1.12085e-157
NZ_AP018280.1\|WP_096617388.1\|3435966_3438723_-\|DUF11-domain-containing-protein	gnl\|CDD\|273634	TIGR01451, unnamed_protein_product, conserved repeat domain. This model represents the conserved region of about 53 amino acids shared between regions, usually repeated, of proteins from a small number of phylogenetically distant prokaryotes. Examples include a 132-residue region found repeated in three of the five longest proteins of Bacillus anthracis, a 131-residue repeat in a cell wall-anchored protein of Enterococcus faecalis, and a 120-residue repeat in Methanobacterium thermoautotrophicum. A similar region is found in some Chlamydial outer membrane proteins.	0.00268234
NZ_AP018280.1\|WP_096617394.1\|3446218_3447100_+\|lipid-kinase	gnl\|CDD\|183857	PRK13057, PRK13057, lipid kinase.	0
NZ_AP018280.1\|WP_096617386.1\|3433248_3435126_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_AP018280.1\|WP_096617384.1\|3430455_3433275_+\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.12209e-54
NZ_AP018280.1\|WP_096617382.1\|3424809_3429909_+\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.19e-120

>NZ_AP018280.1|WP_096617382.1|3424809_3429909_+|hypothetical-protein
MQDDRTETSLEVNNEKALQQLAWAIENSVGKFKLILARCNYASLRSRLIHRLQEICQVEISVLQLRESERTLFAAVREEFGENLPAALMVLGLDRVEGLSQMLANVNQVREEFRKHFPFPLVLWINDEIYRQLMQFAPDLESWATSKSFAIQKDELENHFREIANLWFSDNLRLDIYDCLILKSELAAVQRDLLGDEILSNWELEADLETLWGFVEKVTNKRDAAIEHYQKALSLWRQVDNVEIQTENKLNENKLNENKLERQAKIIGEICLCYYFKALKHQDKTHSDWQLTKDYVGEYLKFIDVNQRLDLINYASIPLGEILRDLQEWEVLKNIFNRLSASHRAENNKLDLARDYGFLAEAALGEKNWLEANSYARQALDLIKDLSPTLILPGEGQEVVGLEAEKGFEKGLYLCILAKSQYYLGEKLEAIRNLEAARELSRPLEDVRLYIDILNYLQKLYFEQKEYLKAYDIKQEQFSVEQQFGLRAFIGAGRLQSFKGDGFSTQEYRNIQTTKYSEEIAPEIAASTRQLDVERLVARVGDTQHKLTVIYGQSGVGKSSLVNAGLEPALKNKAIGIKNNLPLVVRVYTNWQEELARQIEENVIFPPSLVVNGVERLSSSIFEKLTEIEQRHIRTVLIFDQFEEFFFVCTEPGQRREFFEFLANCLNVLSVKVFLSLRVDYLHYLLECNKLPNMKIIGNDILSSNVLYELGNFTPDDAKSIIQRLTEGANFLLEPALIDKLVEDLAGSWGEVRPIELQIVGAQLQAENINTLAKYDLLGNQGGEKAKEELVKRYLQAVVKNCGTENMQVAELLLYSLTDDKGTRPLKTRAELERDLKELVNSSHGLDIHQLNLVVEILVKSGLVLLLPEKTDDRYQLVHDYIAVFIRQQQEPKLKVLMEELEKEREQRQVSEEQRKISETKLNKFLKRALAGSIVAGFGLALLSITTGYQAWEANKQKQQADIHAVEAQLNSYEAFFNSGENRDASITALKLAETLKRGKGVTAANQMQATAALWQAVHSNYPVIEQTTLVGHSSYVNGVGWSPDGTTLASASDDNTIKLWDTITGKPLKTLTGHSSEVIDVEWNTDGIILASASRDKTIKLWDATTGKPLKTLTGHSSYVNGVGWSPDGTTLASASDDNTIKLWDVTTGKPIKTLTGHTSGVNAVVWNGDGRTLASTSWDNTIKLWDVTTGKSFKTLTGHSSEVIDVEWSTDGKNLASASRDKTIKLWDVTTGKLLKTLTGHTSEVYGVAWSTDGKNLASASRDKTIKLWDVTTGKPLKTLTGHSEVVIGVAWSPDGKTLASASSDKTIKLWDTITGKPLKTLTGHTSTVMGVAWSVDGKTLASASWDNTIKLWNATTGKTIKTLTGHSEVVDGVAWSPDGKTLASASWDNTIKLWNVTTGKPLKTLTGHTSGVYGVGWSPDGKTLASASSDKTIKLWDATTGKPIKTLTGHSEVFIDVGWSPDGKTLASASSDKTIKLWDATTGKPIKTLTGHSEIVRSMVWSPDGKTLASASSDKTIKLWDTTTGKPIKTLTGHSEAVDGVAWSVDGKTLASASWDKTIKLWDTTTGKPLKTLTGNGNSVTGVVWSPDGKNLAAASGDEIILWDLDFDNLVKSACSRLDNYLPFHTEVLTDLKSCQTPSLLARAAEVLVVQGEQLVRNGDSEAAVAKFQQAQKWNPQLKFDPEEKAREFQMEERLK
>NZ_AP018280.1|WP_096617380.1|3423312_3424659_+|KAP-family-P-loop-domain-containing-protein
MAIDLHRFFEATDPSKTLVVNLPEDRKYYIDFSSVRGGDVITKLKQTIAYFKPNKPTCQLFTGHIGCGKSTELLRLLLELEKDGFHVIYFESSEDLEMTDVDIGDVLLAIARRVSQSLEKINIAEPRRLKELLQGAWNVLNSEVTGVKLKVPNVGDIGFSAEKEKFSLSLGIGEITSKAKSDSTLRERLNQYLAPQKVKLLAAINQELLEPAIAELKQQGKKGLVVIVDNLDRIDNRVKAWGRTQQEYLFVDQAESLNKLNCHVVYTMPLSLKFSNDYGMLTQRFDDPKVLPMVPVKLPDGSIHEQGMALMRDMVLARAFPDLNSVERLSKIAEIFDNEMTLDRLCMASGGHVRDVLKLLNTCIQEEMALPLTRRTLETVIIGRRNEMVLPISDEEWELLRRVKEKKKVSDDSGYQKLIRSRFVFEYRDNGEFWFDVNPILAEARELQ
>NZ_AP018280.1|WP_096617378.1|3421040_3422720_-|hypothetical-protein
MNLYKIITALKNPLYTSTEKLSWRQIALPLILSIGFSLFYSFLALQKGLRTAYVAQDDAREYVFWMQKFVDPELFQHDLIADYFQSITPWGYASLYKIMAYFGVEPLFLSKIIPTFLGLIITIYCFSLCIKIFPVPGAAFLITLLLNQSLWFKSDLVSATPKSFVNPIFLAFLYYLITGSWLNICLLILLAGLFYPPLIFICLGILLMRLRHHYLWVMTITGLAFLVMLPYIFTSAQFGPVVTATQAFMMPEFWPGGRHPFFHPHPLRFWLIEQHSGILPPLMPPLIWLGLFFPLLRRKIHKFPLMNLVNSQAKILPQIIIVSLTLFFTAHAVILKLFFPTRYTIHTFRIVMAIAAGITLAVILDWLLRTYRQKHQFWQLGLAITLISVLLLYPHLSGRFPTTDYRASTASALYEYLQQQPKDSLIATLSNEADKIPTFAQRPILVGREYALPFHLGYYTQIRQRTIDLIQAQYSPDLTSAKQLIQKYGVDFWLLETTSFQVEYLTRKTWLKSFQPVFTEAVNNLSLEKNPALATVTKACAVVETENFLLLKADCIINK
>NZ_AP018280.1|WP_096617376.1|3420328_3420922_+|Uma2-family-endonuclease
MSYPLDTKPLLLKVRSKYLHVTPEEFDRLCQDNPDLRLELTNNGELIVMAPTFGESGEKNGNLFGRVWAWNEQTELGKTFDSSTGYDFSAIGGGKLSPDVSWIENSRLEGVSLNQFIPVVPDFLIELRSTTDNLKDLQAKMLEYQRLGVKLGLLINPEDKQVEVYRLGRVVETLESPMSVSCEDVLPGFVLSLKKIW
>NZ_AP018280.1|WP_096617374.1|3418618_3420061_+|phosphoglucosamine-mutase
MPALAKSIKFGTDGWRGIIADEFTFERLALVAPVAAKVLFDTYGEKVGNRKIVVGYDRRFMSEDFAQKVAEVVSAAGFDILLSETFAPTPAFSWAAKQENALGALVITASHNPGKYSGLKVKSAFGGSVPPEVTQKIEALLADETVPVAATPGKIEKFNPWGSYCDGISSKVDITKIRHAIASGKLTVFGDVMHGAAAGGLAMLLGDKVKEINSDRDPLFAGGAPEPLPKYLSKLFEVMKNHRQENPGDLNVALVFDGDCDRIAAVDGAGNFLSSQILIPILIDHLTKRRGFTGEIVKTVSGSDLMPLVAKLHNLSVFETPVGYKYIADRMLEANVLLGGEESGGIGYGTHIPERDALLSALYVLEAIVESGLDLGDYYRQLQEKTGFFSAYDRIDLPLASMEVRAKLLAQLQKEPLKEIAGLAVTECKAIDGYKYRLADNRWLMIRFSGTEPVLRLYCEAATLEQVHQTLAWAKDWAES
>NZ_AP018280.1|WP_096617372.1|3417933_3418251_-|hypothetical-protein
MPEFLIDMESIPGIPVGRLYVPYAFTSKPKQLITSHQPVLIYREKHYSTKAQLIQFVAPISEYSRLVSYYSHHRHAKYTSYLLSSASTFFRGLKPPYLNDDEYLC
>NZ_AP018280.1|WP_096617370.1|3416920_3417901_+|replication-protein
MSGFLVLSENSNDSVYSHHVRINKQDKSQINLCDVSKVGKIWDKHKANAERISKYYMNASEGSFERYAMRVKKCSEWLEFELSLEESQNTLQLNLLNAQFCRVRHCPVCQWRRSLMWKAKAYKILPQVVADYPKYRWLFLTLTVKNCDIKELRLTIDWMNKAFKRLTELKAWSVKGWIKSVEVTKGEDKLSAHPHLHILAIVQPSYFSHGYISQARWVELWQQCLRVDYQPIVHISAIAKHHDPKTLIPEILKYQVKESDLVADKEWFLELTRQLHKSRAIAVGGILRHYMQELEKNNQSLIDKSEEINEDNQENLVFRWSGSYVS
>NZ_AP018280.1|WP_096617368.1|3416383_3416680_+|hypothetical-protein
MRARIEDDLLFLHHEDLPEYKKGGSVVRNSYFWALKSIAGRASRHRDWEYESEIWVALGRMLMSFTESGYLGYRETVLEFPVYQGEIPDVLRPVATWE
>NZ_AP018280.1|WP_096617366.1|3414641_3416159_-|NADH:ubiquinone-oxidoreductase
MSQKNRQPWDFGKFVETLSYFEVIPLLNWVQELFQGRPQDSQNKPDGDKKVGVILVAGATGGVGKRVVKSLLEKGYRVRSLVRDIEKARAILGNDTELVVADITKIETLTPLVMANIQAVICCTAVRVQPVEGDTPDREKYNQGVKFYQPEIVGDTPENVEYQGVKNLVDVAAKYLPQADVKTIFDFTQSSVNPNKFNDLSLNNLKNIWGALDDVVMGGVSSSNMIFTDNVAIFTGNVSTDNSGGFASVRTKNFQPSINLSGYEGIELRIQGDGKRYKLFVRTDSAWDGVGYSYSFDTVDGAWINVRIPFADLIPVFRAKVVKNCPAIDQSRVCSLQLMLSKFEYDGQLNPHFSPGTFALKIESIAAYGGHNLSRFVLVSSAGVTRPGRAGINLEEEPPAVRLNDQLGGILTWKLKGEDSLRESGISYTIIRPCALTEEAGGKELILEQGDNIRGKISRDDIAELCVQALQNTQACNVTFEVKATENSANHKNWENLFAGLETNK
>NZ_AP018280.1|WP_096617364.1|3413866_3414409_-|NAD(P)H-dependent-oxidoreductase
MVKIVGIAGSLRANSYSQMALGLAAQRVQALGAEVEILDLRKMQLPFCDGGDEYPDYPDVKRLQDAVSNADGLILVTPEYHGSVSGVLKNALDLMSFEQLSGKVAGLISVLGGQSNSNALNDLRVILRWTHTWSILEQVAIGQAWKAFSAEGKLLDEKLSQRLDQFAESLVETSQKLRKN
>NZ_AP018280.1|WP_096617384.1|3430455_3433275_+|PAS-domain-S-box-protein
MQQPSRTILIVDDSSEERELYRRYLLQDPDYAYRILEVSLGHQGLELWQQQQPDLVLLNYRLLDLDVLEFLAQLPSPTPQPCLPVIIMTDQGNEAIAIQAIKAGAQDYLIKGQITPERLHLTIYRAIETVHIRTELYQRIEREHVVNLRQADLERESQTELECQLLEAELHQSEERLRSALIASRMGTWDWNIETGCIQWSDNLEAMFGLQPGAFDGSFQMFSERLHPDDRDRVLAEIERVITTGEDYTIEFRVVYPDGTIRWALSQGKVFYDSQGQPVRMMGNDIDITDRKQAEEALQVSEERFRQLAENIDAAFWMREVSENRISYLSSAYERLWGLNPQELYENQQAWINYIHPDDREATDRAFWEKARLRQFDQEYRIILPDGRTRWVRDRCFPIQNQSGEIYRFTGIAEDITDRKQIEAALWASHDTFRHLVENSPFGVYVVDADFRLFQISNGAKKVFANVRPLIGRDFAEVLHILWPEPFASEAIAHFRHTLATGKPYHAASMVERRHDTDQVESYDWKIERIMLPDGRFGVVCHFYDLSGRQQLLQREQAARAEAERANRIKDEFLAVLSHELRSPLNPILGWTQLMQSRKFPPSKTAEALATIERNAKLQTQLIDDLLDIAKILRGKLSMNVAPVDLAFVIEAAIDTVRTAAVTKDILLRSVLPQIGQVSGDATRLQQIIWNLLANAIKFTPAKGQVEIHLEREGNQAKITVSDTGKGINPNFLPHLFESFRQEDASTTRQYGGLGLGLAIVRHLVEAHGGTICADSPGEGQGTTFIVKFPLLDAASEQPTSEAVAINKLDLTGMRILAVDDEPDARELLMVLLTQYGAEVLTVTSATEVLANLELFQPDVLISDIGMPEVDGYVLMQQIRALPPEKGGRILAIALTAYARIEDYQQAIASGYQRYLTKPLDLDQLVKVVVELFHCDTFS
>NZ_AP018280.1|WP_096617386.1|3433248_3435126_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGTQAATEILLAGLEKLEYRGYDSAGIATIWEGEVNCVRAKGKLHNLRSKLEQLEAPAQIGIGHTRWATHGKPEEHNAHPHMDTVNRVAVVQNGIIENYRELRDRLKSFGIDFRSETDTEVIPHLISQYLREEIAMGESDSPFFDAVRKAVQELEGAFAVAVISADFPDELIVVRQQAPLVIGFGQGEFFCASDTPAIVSHTRAVLPLENGEIARLTPLGVEIYDFTGKRLKKQPRLLNLSPTMVEKQGFKHFMLKEIYEQPGVVRASLDAYFNASEESPINLGIPADFYADLEQIQIVACGTSWHAALVGKYLLEQLAQIPTQVQYASEFRYAPAPLTPNTITIGVTQSGETADTLAALAMEKERRQGRDAKYQARLLGITNRPESSLGHMVPHIINTLAGIEIGVAATKTFIAQLMAFYALALDLASRRQTLPQERIAEIINGLRLIPKEIEATIDIQDKLTEQLAHDFAETQDVIFLGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIAVPGSVYEKVISNSQEAKARDSRLIGVTPISDGEAGEIFQDLLTVANVDELLSPILTVIPLQLLSYHIAARRGLDVDQPRNLAKSVTVE
>NZ_AP018280.1|WP_010997613.1|3435441_3435687_-|photosystem-I-iron-sulfur-center-protein-PsaC
MSHTVKIYDTCIGCTQCVRACPTDVLEMVPWDGCKAAQVASSPRTEDCVGCKRCETACPTDFLSIRVYLGAETTRSMGLAY
>NZ_AP018280.1|WP_096617388.1|3435966_3438723_-|DUF11-domain-containing-protein
MKSAKKNFTNQYLYRYLLKLIHCLILISTTFSHQGLILLLNTNKVSAQQAPQLCATPGRDNSTSITGVINTYYPGTAISGTNITLGARRGANIDIQAGDLLVIMQMQGNNAGEYEYAVAEQISGNSLTVRGANNGALLNTYINSPANNLQGQQTFQVIRVPQYLNANISSNVTAVPWDGSSGGVVVFDVAQQLDLSGSIDVSGQGFRGGAGIRLGITPSLGETLPSPEATYEGLNAPSPANAATNIGANGSKGEGTAGTPRFTFNAATNSLNPDPGVANEGYPGGSFGRGAFGNAGGGATDGDPAGDDVNVNPTNSTVISAVGNDENSGGGGGANWGVGGQGGLTWFTQKDIGGRGGNQFAAASTRVIMGGGGGAGSNNDGAGTPPNGLASSGAAGGGIVLVRAGTFSGQGTVNASGSNAPIQLTSTSNIQFNDGGGGGGAGGSVIFTAQNTSTTNPTNLSVDVSGGDGSDIRRGIPHGPGGGGGGGFVAANVPLAPTTNVTGGLAGDFFDIQIPSPDGSSVNDSGNYGAVGGGNGTIQTSGTIPGIASGAECLRQPSIYKSVRFLRDNDNSGNPTIGDDLQYTLTIINPNAATIANISISDRIPAQLQVLQDANNQIQFPTGFQAASSLPTSSFNGTGQFIPLTNSGSLPANAQLTLIYNARILPGTVGQIENIAGIDLTPNDANIQPEILADASDSTNPSQPGSGLNPGIADANRNINQPNNSNADPTIIIVQTPITPGNVTLYGVKRITNVIRNGIPITGVDFSQAIDDPNDSNDNTNIWVNSAIAPTGVIRIDPQLLLKIGDEVEYTIYFLVNGNQTIPNARFCDPIPVGTSFIPNAFGSGNGISLNIANTLTNQTNNSDADRGSYFSPVAPLPANNVCFNQSNPTGAVLVNFGTLDYTPGNNAGFVRFRVRVE
>NZ_AP018280.1|WP_096617390.1|3442985_3443912_-|DUF11-domain-containing-protein
MRFIFKQWQHHPITLILMLPGIITSNILPVSANEIVNTAVFGGDNFRQPTNTNRALFNAEFAELRITKTADKVAVKPGDTVLYRITIRNNGNANANNLTLTDTLPLGLVFETKSLQAAIIANNTTTPIPVSATKSGDRNFNITFAGSLPPQGILNLVYAATVTPDGMRGNGRNLAVATAGRARSNTASHQLKIRPGIFSDCGTLLGRVFVDKNFDGEQQPGEPGIPNAVIYMDDGNRIITDANGMFSVANVIAGNRSGTLDLTSLPGYIQAPNLYRIDKNSQSRLLKLAPGSMGRMNFAVTPAFREGR
>NZ_AP018280.1|WP_096617392.1|3444852_3445920_+|glutathione-S-transferase-family-protein
MSQPQSSLNQTSQAIPVQNKTQKTGKSLPLGLIIKLGKFIWSTMWHVMMSQLAPRNKSGEYIRPQSQFRNFVSSTENSQYPPEASRYRLYVGLGCPWAHRTLVTLALKGLETTISVSIVSPSAAGIWVLNEEEEGCRTVPEIYNLAQYNLTQSQYQGRCTVPILWDTQTQTIVNNESAEIIVILNSQFNQFAKNFALDLYPDELRESIDKWNEKIYHAVNNGVYRCGFAQTQSAYEQACNDLFTTLDEIDIALATSRYLCGDQLTLADVRLFTTLFRFDVVYYGLFKCNRRRIQDYQNLGAYLRDLYQLSGVADTCDLESVKRDYYGNLFPLNPGGIIPLGPDISYLLKPHERNH
>NZ_AP018280.1|WP_096617394.1|3446218_3447100_+|lipid-kinase
MNQRALLLVNRHSRQGQKNLSEAIGYLEKLGFDVTEESTEHPQHLAEVIKEYKNKVDIVIVGGGDGTLNAAVDYLVETQLPLGILPLGTANDLARTLGIPNSLPEACQVIATGEEKKIDLGWVNGKHFFNVASLGLSVKITQRLTKKAKKRWGILAYAATALQVIWESRPFSAEIHVNGESIAVKTVQIAVGNGRYYGGGMAVVHDATIDDQRLDLYSVEIQHWWQIIPLLPAMRNGRHIHWREVRALQGQDIEIFTRKPRPINTDGEITTYTPARFRVIPQALKVLVPRTRQ
>NZ_AP018280.1|WP_096617396.1|3447294_3447927_+|exopolysaccharide-biosynthesis-protein
MSTPVNSHSVNLKFSQDIKLLLQRLAEKPLTLGDVLAETSERSFSLVIALLVLPFLFPVPPGLTGPFGAACLLLSVQMIGGRKSPWLPKKISSYKFPRPFAKVMLQNLRRVTRVLEKITRPRLAKIANNNWTWRLNGLCISWLTLLLISPIPLTNPIPTIGILLLAVAAIESDGLLMCIGYILTILISLLFAFIGYALWMAPGLLPKFIS
>NZ_AP018280.1|WP_096617398.1|3448493_3449273_-|photosystem-II-S4-domain-protein
MLPREELLKGIENRETVVRVIDQAEQAIKTWEIVTTDFLSPPELAEIQRAFSRLTEIHLVAWGGYPQAERQRIAIARSELPLEQSQVELVALDIAGNFLFDTATHRDFLGAMLGTGIVRDKTGDIIVLGERGAQTIVVPELADFLEIHLKQVRSVPVQVRRIELSELKNREPKKKELTTVEASLRLDAIASAGFGMSRSKMVDLIDGGDVRVNWKEITQASSQLKTGDLVAIRGKGRLEVGEIAVTKKDRYRVQLTRYM
>NZ_AP018280.1|WP_096617400.1|3449421_3449973_-|N-acetyltransferase
MTQILYIDTQRLELIPCSLEVAQATINRDKPLLEKLLTAYVPDDWYTTEVQDFLPKYIQMLANDASQLGYGVWLMIRTDDSTLIGDLGFGGKLAGEESVGEEVLEIGYEVLSAYRDRGYASEAVEALVNFAFTQLEARKIIAHTPENNIPSIRVVEKVGMKNVGTVKLPELPGVNVFKWELVK

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Crispr_ID: NZ_AP018280_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_5

3861631-3862463

TypeI-D

I-D,II-B

Consensus_repeat	Method
ATTGCAATTCAAACTAATCCCTATTAGGGATT-----------GAAAC	PILER-CR
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CRISPRCasFinder
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CRT

11 spacers

cas2,cas1,cas4,cas6,csc1gr5,csc2gr7,cas10d,cas3

The CRISPR arrays of NZ_AP018280_5

>merge|NZ_AP018280|5|3861631-3862463|PILER-CR,CRISPRCasFinder,CRT
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACGTGCATGATGTTGATAACCAAGGATTAATTTACATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACTAATTAAAAAGCTTGGGGCTATCAGATACTTAAATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACACTTCTATGCCAAAGCGATCGCCGGACTGAATTGCATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACTTAACCTAAAAACCGCGATCGCAGTTCATTTAAAAATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACAGTTATAAATCGCACATCCAGCTTCGTAATATACTGGATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACTTAAAGAATACTAAGCAAAGATATCTTAATATGATAAAATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACCAATGAATATGTCGGCAATGGGTGCAGCCGCTCAAAGGAATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACAATTAAAGGTAACTGATGTATTACCTATCATTAAATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACTTTGAAGTTATACATCAACGAATGTAGTAACCTCAATATTGCAATTCAAACTAATCCCTATTAGGGATTGAAACCCCGGTTTTTCTGATTTTCCTTTGTATCAAAGTATTGCAATTCAAACTAATCCCTATCAGGGATTGAAACTGGTTAAAAGCTTCTCTGTAATGCATCTTTACATAATTGCAATTCAAAATAAGTAGCCAGGTTTAATTAAAG

>NZ_AP018280|5|3|3861631-3862391|PILER-CR
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	GTGCATGATGTTGATAACCAAGGATTAATTTAC
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TAATTAAAAAGCTTGGGGCTATCAGATACTTAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	ACTTCTATGCCAAAGCGATCGCCGGACTGAATTGC
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTAACCTAAAAACCGCGATCGCAGTTCATTTAAAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	AGTTATAAATCGCACATCCAGCTTCGTAATATACTGG
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTAAAGAATACTAAGCAAAGATATCTTAATATGATAAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CAATGAATATGTCGGCAATGGGTGCAGCCGCTCAAAGGA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	AATTAAAGGTAACTGATGTATTACCTATCATTAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTTGAAGTTATACATCAACGAATGTAGTAACCTCAAT
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CCCGGTTTTTCTGATTTTCCTTTGTATCAAAGT
ATTGCAATTCAAACTAATCCCTATCAGGGATTGAAAC

>NZ_AP018280|5|5|3861631-3862391|CRISPRCasFinder
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	GTGCATGATGTTGATAACCAAGGATTAATTTAC
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TAATTAAAAAGCTTGGGGCTATCAGATACTTAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	ACTTCTATGCCAAAGCGATCGCCGGACTGAATTGC
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTAACCTAAAAACCGCGATCGCAGTTCATTTAAAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	AGTTATAAATCGCACATCCAGCTTCGTAATATACTGG
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTAAAGAATACTAAGCAAAGATATCTTAATATGATAAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CAATGAATATGTCGGCAATGGGTGCAGCCGCTCAAAGGA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	AATTAAAGGTAACTGATGTATTACCTATCATTAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTTGAAGTTATACATCAACGAATGTAGTAACCTCAAT
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CCCGGTTTTTCTGATTTTCCTTTGTATCAAAGT
ATTGCAATTCAAACTAATCCCTATCAGGGATTGAAAC

>NZ_AP018280|5|3|3861631-3862463|CRT
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	GTGCATGATGTTGATAACCAAGGATTAATTTAC
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TAATTAAAAAGCTTGGGGCTATCAGATACTTAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	ACTTCTATGCCAAAGCGATCGCCGGACTGAATTGC
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTAACCTAAAAACCGCGATCGCAGTTCATTTAAAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	AGTTATAAATCGCACATCCAGCTTCGTAATATACTGG
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTAAAGAATACTAAGCAAAGATATCTTAATATGATAAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CAATGAATATGTCGGCAATGGGTGCAGCCGCTCAAAGGA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	AATTAAAGGTAACTGATGTATTACCTATCATTAA
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	TTTGAAGTTATACATCAACGAATGTAGTAACCTCAAT
ATTGCAATTCAAACTAATCCCTATTAGGGATTGAAAC	CCCGGTTTTTCTGATTTTCCTTTGTATCAAAGT
ATTGCAATTCAAACTAATCCCTATCAGGGATTGAAAC	TGGTTAAAAGCTTCTCTGTAATGCATCTTTACATA
ATTGCAATTCAAAATAAGTAGCCAGGTTTAATTAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096617998.1\|3857152_3857860_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl\|CDD\|187842
NZ_AP018280.1\|WP_096617996.1\|3856133_3857147_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl\|CDD\|375747
NZ_AP018280.1\|WP_096618018.1\|3870304_3872092_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_AP018280.1\|WP_096618000.1\|3857886_3858291_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618002.1\|3858349_3859189_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NZ_AP018280.1\|WP_096609659.1\|3862567_3862819_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618012.1\|3868220_3869339_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP018280.1\|WP_096618556.1\|3861094_3861367_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_AP018280.1\|WP_096618010.1\|3867868_3868072_+\|high-light-inducible-protein	unknown	unknown	gnl\|CDD\|177653
NZ_AP018280.1\|WP_096618555.1\|3850253_3852365_+\|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl\|CDD\|187841
NZ_AP018280.1\|WP_096617994.1\|3852724_3856069_+\|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	gnl\|CDD\|274469
NZ_AP018280.1\|WP_096613173.1\|3862890_3864126_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618016.1\|3869789_3870287_-\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|206640
NZ_AP018280.1\|WP_096617992.1\|3852401_3852659_+\|DUF433-domain-containing-protein	unknown	unknown	gnl\|CDD\|225291
NZ_AP018280.1\|WP_096618006.1\|3859953_3860958_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274976
NZ_AP018280.1\|WP_096618014.1\|3869384_3869789_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618022.1\|3873195_3874533_-\|transporter	unknown	unknown	gnl\|CDD\|238536
NZ_AP018280.1\|WP_096618004.1\|3859290_3859878_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_AP018280.1\|WP_096618008.1\|3864280_3867424_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226167
NZ_AP018280.1\|WP_096618020.1\|3872232_3872835_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237177

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096617998.1\|3857152_3857860_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl\|CDD\|187842	cd09711, Csc1_I-D, CRISPR/Cas system-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog; also known as CasA/Cse1 family.	1.78118e-87
NZ_AP018280.1\|WP_096617996.1\|3856133_3857147_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl\|CDD\|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	8.28638e-173
NZ_AP018280.1\|WP_096618018.1\|3870304_3872092_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	5.84894e-23
NZ_AP018280.1\|WP_096618020.1\|3872232_3872835_-\|hypothetical-protein	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	0.000738895
NZ_AP018280.1\|WP_096618002.1\|3858349_3859189_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	2.05729e-50
NZ_AP018280.1\|WP_096618012.1\|3868220_3869339_-\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	7.71626e-29
NZ_AP018280.1\|WP_096618556.1\|3861094_3861367_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.17317e-38
NZ_AP018280.1\|WP_096618010.1\|3867868_3868072_+\|high-light-inducible-protein	gnl\|CDD\|177653	PLN00014, PLN00014, light-harvesting-like protein 3; Provisional.	0.000118473
NZ_AP018280.1\|WP_096618555.1\|3850253_3852365_+\|type-I-D-CRISPR-associated-helicase-Cas3'	gnl\|CDD\|187841	cd09710, Cas3_I-D, CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Diverged DNA helicase Cas3'; signature gene for Type I and subtype I-D.	2.65649e-81
NZ_AP018280.1\|WP_096617994.1\|3852724_3856069_+\|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	gnl\|CDD\|274469	TIGR03174, cas_Csc3, CRISPR type I-D/CYANO-associated protein Csc3/Cas10d. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc3 for CRISPR/Cas Subtype Cyano protein 3, as it is often the third gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	0
NZ_AP018280.1\|WP_096618016.1\|3869789_3870287_-\|GTP-binding-protein	gnl\|CDD\|206640	cd00154, Rab, Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases). Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which mask C-terminal lipid binding and promote cytosolic localization. While most unicellular organisms possess 5-20 Rab members, several have been found to possess 60 or more Rabs; for many of these Rab isoforms, homologous proteins are not found in other organisms. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Since crystal structures often lack C-terminal residues, the lipid modification site is not available for annotation in many of the CDs in the hierarchy, but is included where possible.	1.75383e-45
NZ_AP018280.1\|WP_096618022.1\|3873195_3874533_-\|transporter	gnl\|CDD\|238536	cd01116, P_permease, Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.	3.34284e-97
NZ_AP018280.1\|WP_096617992.1\|3852401_3852659_+\|DUF433-domain-containing-protein	gnl\|CDD\|225291	COG2442, COG2442, Uncharacterized conserved protein [Function unknown].	1.33222e-24
NZ_AP018280.1\|WP_096618006.1\|3859953_3860958_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274976	TIGR04093, hypothetical_protein_L8106_25395, CRISPR-associated endonuclease Cas1, subtype CYANO. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.	4.07789e-138
NZ_AP018280.1\|WP_096618004.1\|3859290_3859878_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	2.98788e-53
NZ_AP018280.1\|WP_096618008.1\|3864280_3867424_-\|hypothetical-protein	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	4.86074e-06

>NZ_AP018280.1|WP_096618556.1|3861094_3861367_+|CRISPR-associated-endonuclease-Cas2
MFVVVSYDIPEDKRRTKIHKILKSYGQWMQYSVFECDLTDTQYAKLRSRLSKVIKPKEDSIRFYSLCGCCQPKVERIGGEMPRDNTIFFA
>NZ_AP018280.1|WP_096618006.1|3859953_3860958_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYITQEDTFIAKIDERLNVRFEKKTILDVPLLKIDGVVIMGRATISPAVITELIQNKISLTFLTINGKYIARLEPEMTKNIFLRSAQWKAAGESIQAIHVAKAFVRGKLKNYRNSLLKTQRNYTEIDTSEGISQIESSLVSLEKATTINSIRGCEGAGSAAYFGCFNDFIRVDNFSFNNRNRRPPIDPINSLLSLGYSLLRHDIQGALNIVGFDPYLGYLHTERYGRPSLALDLMEEFRPLIVDSLVLGTINRKMFKPSDFVTEPVSNAVSLTKEKLHEFLKLYQQKKLDKITHPVLGVKKSYQEIFEIQARLLGKYLMGETDKYPPLIMK
>NZ_AP018280.1|WP_096618004.1|3859290_3859878_+|CRISPR-associated-protein-Cas4
MTEYIPIAALNQFAYCPHRCWRMFCIGEFTDNQYTIEGTSLHDRVHTTGEGNREETCQVRAIWLKSDKYQLIGKSDLIELENGEWIPVEYKRGKKGEWDNDELQVCAQALCLEEMTGKVIKNGYVYYAQTHQRQLVEISDELRRETINTIADVTRLIETGAMPQAVYSPRCRGCSLYEQCLPKLAEKVNKYCEVG
>NZ_AP018280.1|WP_096618002.1|3858349_3859189_+|CRISPR-associated-endoribonuclease-Cas6
MPHSLILNIIPQSPIYPNYLTGRHYHALFLNLISSVDRTLGDKLHDSTADKPFTLSPLQVKMDEGIRQRREAGNSHILQYQQQKPIPPGTPCWWRISLLDDTLFSKLTQLWLNINPEQPWHLGSADLFITSILGTPQFTQPWANACSYDQLYDRASKSEKTINFALATPTAFRQGSYDTALPSRDSVFKSLLQRWNKYSGMEFQSDWIESIFPSFFNIKTEIASDSRSKFIGCVGEISYRIMGDVEVGLIKQVNALADFALYAGVGRKTPMGMGMLRRI
>NZ_AP018280.1|WP_096618000.1|3857886_3858291_-|hypothetical-protein
MKIDDRSQAIALTEKLKASLPMKVRPGKQFLLMLKQQGEIANPDKEYEVTSVLYTGDEGGISCALTSDPTDKTAYCVSITHLEIDSNHPLAAELKEYQRQRTRKLFLQDKGGFAKEFLANQSVKTKKRSSGFGK
>NZ_AP018280.1|WP_096617998.1|3857152_3857860_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MVFIYRCQIELHDSIYFATREIGRLYETEPIIHNYALCYALGLVDSDKYATTVPEEHSYRYFCPEQVPKYEEHLTPLNQQGIYVTPACSVSHTSILNTWKYANNNYHVEMEKTQKNIPSFGRAKEIAPESIFEFFVISQKELKFPKWIRLGKWMSKAEVTVEKLPQPETKRDLFICTHPLNPLDVMFSNQVISYDVVNMPPVSLIQNVQMRGQYYYFENIKDVILPVNISYRFRN
>NZ_AP018280.1|WP_096617996.1|3856133_3857147_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MSFLKTVDAKFFHSEIPAKPMGKYAHFITIRVTESYPLFQTDGELNKAKVRAGIQHQEPISRLAMFKRKQSTPERLTGRELLRNYKIGDWEKCDYNVDFSKTTPDCIFYGFAIGDAGSEKSKVVVDTAYSITPFDDSHLNFTLNAPFENGTMSRNGEVTSRINSQDHILPQTFFPSIVTLKDPTEAGFLYVFNNIIRTRHYGAQTTRTGRVRNELIGVIFADGEIVSNLRWTQKIYDLLNFNGKINPPDPLNEDNVREAATKAIAELMTQEFISHNDYIGDRFVPLLDEVKLITSNENKLKELLTQANVESSAYAQKYISKNSEKGKKGKKASAATE
>NZ_AP018280.1|WP_096617994.1|3852724_3856069_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3
MNEFEDNFDDLPEEVPDFDANREDDDESPIKKELLAIRLFKKAVQKARGNQGNEILEQFTEYVLPNLIQQLAGATAKGGKFFEVTIPKINAERAKEGKLPVDSTRNAGDQSLVAHLLNGFFPTYRIIRHLQTSSVTSPVKRNCDRLQVCIYITSYLLHDYEKFPEYKDWLIASDREEKFSLRDWELNPPKKEDAPNLGRDYIAKKIKDFGLHHLLGEDWQDLIDDIIEISSNSGVKHDSDLGLTTRGLKTLEDDRLDSRIRQDLIDLVSLSDIFASVIKHPRDAEHPRLIKLIDRLSNHQLKLTYHSLSENRGVLTNILNNALIEAHPEEFYTPLLYLPDGVVYLASTDAPTINTDNIQNCVVIKVKFLCAEKLRERQTGFNRDGKGLKFADYYWLFFDAIGLMEVSIDAACRLLPDSKNASSGKRSESLQSYQAQGELSADLNVQFTAEIRIDRLAEFGDILCRGIWGSWSEKVKQAQKDIPKAKRKVPPELDLTVKLAEYLGLSNEIPAVRHIQSLKKTGGVPLDWYYLAAQYFRNNPGKDFAEILEVMRGMVNYAASLIQPILEDFQDILDGWEDLKTYVQRVISLPTGAVITPESDPFLLELQRYNAAKITGRGRENVCAMSSSAYTVTEQMESATLFAPQVYSNRQILFNAQAAKRQICSIWSIEIMLRQILMNQKNAVGGDFEGRKYRYLYLYPTYFFTPETNKFLQLAYNQFARTRFDAELRKHFITEQQIAEFGITNYQKVDTLLIKENLQVEDDRTFKISFPEQETLTFFFLGLPPGRDATDTESWVTPAWLAFALPLVMDVKVVASESPVPPFISGADFEETVLLDGEHQAIHSLIKKDTYRLDSILPIDSNQRDFSPLNALTAAYAIHLEVNRKKDGDPDWGKLSDLARDLETSPLYVFHYLNKWLRKQDKIETVSIAKTRLYLEFYYYFEPGGESVNQLRELTMLYRKFYRAKSQYAKANAVLKPIDEAADVILKIDKAVASDADSLIDVVAARLAKLMNNVRRRTAEGKPTITFVDGKWKPALTSEEERQAVYDFAKYFVKEIFEGSFKSDRARLAGTQLNLIRDTCEYLYRLADDEERKNRKVDEPDELPETEVDVDNAA
>NZ_AP018280.1|WP_096617992.1|3852401_3852659_+|DUF433-domain-containing-protein
MTTNDLLSRIFIDPNICSGKPCIRGHRIWVSLVLDYLASGTSIEEILEAYPSIEREDVFACIAYGSEMARGAFVELPLDTKEASA
>NZ_AP018280.1|WP_096618555.1|3850253_3852365_+|type-I-D-CRISPR-associated-helicase-Cas3'
MSVIYSIKLKPVYSQTVTTPTSIILPDSCSLSWHQAETYKELQDPNIEVIFNTAMTGDGKSLAAFISAMNHRTYSLAMYPTNELVRDQEKQVQGYKSQFLPKYDPQIYRLTAAILDDYINIGKLPSRLEGLEDIAALNEIILTNPDLFHYIHNFYYLRGKIDNPDRLFRRIDERYKLFIYDEFHIFSSPQIASVVNTMLLIRNTANHPKKFLFLSATPNHLLQGYLENAGIKTKIINPIDVAAYKFDSDSDDSNWRQISQPIDLIFPQRLEPNLRSSYEWLEENIEQVILEFFQNNPNSKGAIILNSIAAVKKLLPKLKAVFEPQWQVRENTGLTGETQKRDSVAEADLLVGTSTIDVGVDFRINFLIFEAADAGNFIQRFGRLGRHAGFEKYQAYALIPNFLLARLFADKSPPLEDKETYDRITFTNAIRSAWIDRNEFERYPKRWGGIQSAYIYSKLQGNYHMKQKYPDVAKKFGTDVQKALGISIKQMNGQFYHCQNEGKTKIIDEARSFRGSSQLDCAIYDLTNIEEPEVDRFKTYNLPGILSNFIFELWDENSFMEKAKKAGVSTKRFEKALCYLKLKDFRDVREDWHFHYPGNIRELAKTSKVQVLKDLEICQPHGYGIQQISDAVSRRKLVCFISDRDRNYLRAVLRLPMHFQVYPLTDQAENRGSWYSIAFGQDALLLETLTWHWKPKEDEGWIC
>NZ_AP018280.1|WP_096609659.1|3862567_3862819_+|hypothetical-protein
MQEFKSPVSRLARLFQKGRDNWKEKALLKQKKIRALEIKVRDLLDSREEWKNRALMAESKLKELNIEGDLDEKKRKFKSKQKS
>NZ_AP018280.1|WP_096613173.1|3862890_3864126_+|hypothetical-protein
MECGISFRGVEKVFELFNNYEEQATPSFSCVRKWLARIGIYELTKEKEYRDDWIFIVDLTLELGKQKALVILGVSQQHIEENVMKQKRGLAHEDVKIFGLEIMDSTKGEIIESKLEKISQKVGVPVQIVADNGSDLARGIKLYQQNHPDIIYTHDVTHAMALLLKYQLDSDERYQSFIQKCNISRQKLQQTDLSFLSPPTQRSQCRFFNVERLTNWGIKLLNSSPDTLIKLMPDSDPSLITQKIVDKLGWLVDYESDLIQWNQMVSLTRGVETQLKQSGISHKTLDFFEQNKVIFDDNSLQKLQQSILGYLSVQCRKIKNQSTFLATSDVIESLFGKYKQFSARCPFKEMGQMLLTICLSTMNLTTALIKNALETISFSDVEAWLSEVFGQSTLSKRKTLFSGDCDDIKSA
>NZ_AP018280.1|WP_096618008.1|3864280_3867424_-|hypothetical-protein
MFQTLKITWGLVKSPIMWFLQTPVDTTQISPAQTSIFTSGPRFFVALIAGVILAFAIQFVLTNLSVAAGISYLGHNSDSDSSDGESGSFGGTIRKIGTAVGLWTVITVTIALAIASFLAVKLSLLILSPSLGAILGLVIWGAYFLLLVWVSSTTVGSLIGNVINTATSGFQAIMGTATAAMGAKAVNNQVVATAEAAAAALRKEFGSALDPAGIRDNIEDYLEKLRPQELDVKKIRAEFENILNDPELKAVTSTADLSSQVSRDRLVSLVSDRTDLSKRDVNRIADTLYTVWQQVVSQQSRNPGGQDRMGELVDYLKNLKPGQSKTDELNAKLDSLIAEMRSQQKTDYKAAEKTPGPVQSTLQQGISALTGIVLGRTDLSDFDVEKILETLNQAKNKVTEQADKLGIPTPKQPYSLIRADVENYLLNTYAWQLSPEKIDREFRDIIYDPAADPAQVRQELQLLSRNDFANILHQRGLLTQGEIQRVSDHLEAIRQEVLLNAIAAEEREISYALQRRVESYLLVTPLSNLTPEEIEQNFKPLLTDTDADYETLSRRLSLIERQQMREILLQRNDMQFQEVEPILDQLEKQRDRVLIESKGLAEQAQYEAETLWLNLESYLRNTGKAELNPDGIRADMRRLVDDPQAGMAAIRARLSRFDRDTLVKLLSQRQDLSEAEANRIIDNVEHSWHDVQHAPKAVIAQAKEQYDTVSTTIADYLRNTGKDELNPEGIQRDLNRLLQNPQQGLTALRYRLSQFDRDTLVQLLSQRQDLSEEQVNQVINSVQTSIQDIIRAPRRLAVRTQERAQTFQAYLEEYLRGTGKEELNPESIKRDINLLLHDPRVGIESFSERLSHFDRDTIVALLKIREDITDIEAERIADNIISVREQFVEQVRNIQRRMQDVIDGIFARIRNYLNSLDRPELNYDSIRRDVRQLFDDPQAGFEALRDRLHSFNRDTLVAIMSSREDISPDDANEIIDQIERARNNVLQRAERIQNEAQRRLEEVKHQAQRQAEETRKAVASAAWWLFVTAVVSAIFSAIGGAVAVMFV
>NZ_AP018280.1|WP_096618010.1|3867868_3868072_+|high-light-inducible-protein
METRPSTELPTIANEYNGKDRNAFIFGWTPQAELWNGRLAMIGFLAYLLWDLSGYSVLRDVLHFIGY
>NZ_AP018280.1|WP_096618012.1|3868220_3869339_-|sensor-histidine-kinase
MNNYITADLFAALNVLVLEYLNIGRFRVSASVPTWVKDICNSKIISGMEVLIPEEQFPFLENFLVDAEEFWQRNENFPLKSGIWVEQDLGGKECHFEASAISVKNQKILVIELLDEDYIEKFSIIQQARANNLNYYQILKENQKKEILIHCIIHDIAGQLSGINCCLALLELENLTPKGKERLEIGRRQSIKQEMLIREVLDAFSAEVQSFESFDIDVKNAPNILKITQEVITILTPNFVLNHMQLKLAHNIDFNADWRVIADKSRLERVISNLVENAFRHSPGESAVVIELFQDQDFILVHINDQGSGVPPEMIANLFQKFSQGKEKKGRIGLGLYFCRITIERWGGEIGYSPLPDGGSRFWFRLPKVKIG
>NZ_AP018280.1|WP_096618014.1|3869384_3869789_-|hypothetical-protein
MLDVPISVITYLMNLMLESRSLAYLLVTKDGCLSSWGGKLADYGVSNLHKGEKVEQQIFFLEGLLPLDNFPLFLPCLKTDEGICADIHMFPSEEGDWVLLLDATIDEIQLSLIQQYANESVLRDEKLTRIFNQS
>NZ_AP018280.1|WP_096618016.1|3869789_3870287_-|GTP-binding-protein
MLQKKVCMVGAFATGKTSLVARYVHSIFSDNYQTTVGVKIDKKTINYRGKELNLILWDLYGEDEFQKVRMSYLRGSSAYLLVVDVTRYNTLEKAFSLQNRVEETIGKVPFILVINKSDLTDEWEIDKAEIEKLEQKGWIIIQTSAKTGQGVEEVFETIAQKILEG
>NZ_AP018280.1|WP_096618018.1|3870304_3872092_-|OmpA-family-protein
MTKFSTNGFSTESPNVDNRESKEKIKDELDELRALLLGVEPNKLHQIYEYIENQQIKPEDISRVLPEAVILRSLQDRQLVEAMVPTIEQAVEASVKKDLNVLSDAIFPIMGPSTRRAIATALEEMIQSLNQTLEHSLSIQSFKWRLEARQTGKSFAEVVMLRTLVYRVEQVFLIHKNTGLLLQHIVAPQVAAQDPDLVSAMLTAIQDFVRDSFNVTTGDRLQTLNFGELTIWIEEGPTAVIAGIIRGNAPQELRLIFQDAIEKIHLRFDNELYNFQGETEPFNLSQAYLENCLEVRYQVPPKTNYTYAYTFIGLITFGLCVWTALTIREQQQWNTFVKQLNSEPGITITKVHKESGKYIITGMRDPLAVDVSTILKQNNLNPAIVNHQLEPYLSLQPEFITKRAEALLQPPQTVSLKVESNGILYAIGSAPQKWILEARNMWRFIPGITQFSENKLTNLDISELEKYQAEIEREKLLFQEGKTDLIASEKPKLETIIVNLQKSNFIAKYLQKNININIIGHTSITGSEQYNLQLSQARAEQIKYYLIARGLNQENITTEGLGANKSLSSSTTRENQDIDINRRVSFKLTITNINK
>NZ_AP018280.1|WP_096618020.1|3872232_3872835_-|hypothetical-protein
MHSPDMEYDNDRNVLDSTQITSVQSSKLTNNGYDVSGINNLDKVRDILFGNQLRDVEKKFARLEERLSKELVNLREDNKKRLDNIESYIKQELELLSERMKQEQNNRDESVQNLAEENKKITTALEKRLTQFDEQVSNSQREIREQILNQSKTLQDDLLQKYEEILEILRREAAELRTTKTDRSTLANLLSELAIRLNSQ
>NZ_AP018280.1|WP_096618022.1|3873195_3874533_-|transporter
MENWQALVSIITFTCVIFLIMTEWIHLTIAALLGALLLVFTNVMTLSDAVGYIGKSHGTLALFFGVMVLVRAFEPTKIFDYLATQLVILAKGEGKRLLLGIVAITTPICAVLPNATTVMLIAPLIPPMAEELGVNFVPLLILLVFVANSSGLLTIVGDPATFIVGDAINLSFTDYLVRLSLGGVISVITVVAILPILFRKIWQTKLASLEELPHPQINHPRVLTLGAVIVGLVLLFFVIGEQLPVKLSPAAVALLGAGLAMLLAHHSRIDSVNNILRDVDWSTLIFFMSIFVLIGGLEKTGVINSLSGILSVFLGKNIVFGSIFLVFFIGILSSVVPNIPLVVAMVPLLKQYLVNVGFVSAEILQPDFDGQLPIQVLPLFYAMMFGATLGGNGTLVGASSNIVAAGVSEQHGRRISFKTFLHYGIPVMMLQLITSALYVFFRFLL

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Crispr_ID: NZ_AP018280_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_6

3916772-3917036

Orphan

Consensus_repeat	Method
AGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	CRISPRCasFinder
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	PILER-CR
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	CRT

3 spacers

The CRISPR arrays of NZ_AP018280_6

>merge|NZ_AP018280|6|3916772-3917036|CRISPRCasFinder,PILER-CR,CRT
CGTTTCAATCCCGTTGCCAGGAATCGTAAGGTTTCAAGTGCAGGAATCGGTGGATTTGAGGAGGGAATTAAAATGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGTTCGTAGAGCCTACAGGAGAAAGCATAGATGCTTTCTTCAAGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGTGTACTTTTTCAATCTAGCTACTTTAGCTGCTCTGATAGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT

>NZ_AP018280|6|6|3916772-3917036|CRISPRCasFinder
CGTTTCAATCCCGTTGCCAGGAATCGTAAGGTTTCAAGT	GCAGGAATCGGTGGATTTGAGGAGGGAATTAAAA
TGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	TCGTAGAGCCTACAGGAGAAAGCATAGATGCTTTCTTCA
AGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	GTACTTTTTCAATCTAGCTACTTTAGCTGCTCTGAT
AGTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT

>NZ_AP018280|6|4|3916773-3917036|PILER-CR
GTTTCAATCCCGTTGCCAGGAATCGTAAGGTTTCAAGT	GCAGGAATCGGTGGATTTGAGGAGGGAATTAAAAT
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	TCGTAGAGCCTACAGGAGAAAGCATAGATGCTTTCTTCAA
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	GTACTTTTTCAATCTAGCTACTTTAGCTGCTCTGATA
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT

>NZ_AP018280|6|4|3916773-3917036|CRT
GTTTCAATCCCGTTGCCAGGAATCGTAAGGTTTCAAGT	GCAGGAATCGGTGGATTTGAGGAGGGAATTAAAAT
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	TCGTAGAGCCTACAGGAGAAAGCATAGATGCTTTCTTCAA
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT	GTACTTTTTCAATCTAGCTACTTTAGCTGCTCTGATA
GTTTCAATCCCGTTGCCGGGAATCGTAAGGTTTCAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096618046.1\|3908988_3910065_+\|magnesium-protoporphyrin-IX-monomethyl-ester-(oxidative)-cyclase	unknown	unknown	gnl\|CDD\|237458
NZ_AP018280.1\|WP_096618044.1\|3906448_3907210_+\|heme-oxygenase-(biliverdin-producing)	unknown	unknown	gnl\|CDD\|227685
NZ_AP018280.1\|WP_096618049.1\|3913407_3913878_-\|DUF1772-domain-containing-protein	unknown	unknown	gnl\|CDD\|227787
NZ_AP018280.1\|WP_096618059.1\|3924616_3924961_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618060.1\|3926045_3926270_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618053.1\|3916041_3916575_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618061.1\|3926282_3926546_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618048.1\|3912168_3912882_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP018280.1\|WP_096618055.1\|3919278_3921726_-\|NACHT-domain-containing-protein	unknown	unknown	gnl\|CDD\|227922
NZ_AP018280.1\|WP_096618054.1\|3917947_3918454_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|225943
NZ_AP018280.1\|WP_096618058.1\|3924130_3924475_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618052.1\|3915227_3915806_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|223340
NZ_AP018280.1\|WP_096618045.1\|3907545_3908661_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618050.1\|3913976_3914489_-\|DUF1579-domain-containing-protein	unknown	unknown	gnl\|CDD\|377882
NZ_AP018280.1\|WP_096618057.1\|3923336_3923924_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_AP018280.1\|WP_096618047.1\|3910151_3911765_-\|magnesium-protoporphyrin-IX-monomethyl-ester-anaerobic-oxidative-cyclase	unknown	unknown	gnl\|CDD\|131081
NZ_AP018280.1\|WP_096618051.1\|3914587_3915037_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|225356
NZ_AP018280.1\|WP_096618559.1\|3917383_3917872_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618560.1\|3921956_3922226_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618056.1\|3922459_3923098_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096618046.1\|3908988_3910065_+\|magnesium-protoporphyrin-IX-monomethyl-ester-(oxidative)-cyclase	gnl\|CDD\|237458	PRK13654, PRK13654, magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional.	0
NZ_AP018280.1\|WP_096618044.1\|3906448_3907210_+\|heme-oxygenase-(biliverdin-producing)	gnl\|CDD\|227685	COG5398, COG5398, Heme oxygenase [Inorganic ion transport and metabolism].	1.59709e-100
NZ_AP018280.1\|WP_096618049.1\|3913407_3913878_-\|DUF1772-domain-containing-protein	gnl\|CDD\|227787	COG5500, COG5500, Predicted integral membrane protein [Function unknown].	6.92492e-60
NZ_AP018280.1\|WP_096618048.1\|3912168_3912882_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	6.59305e-32
NZ_AP018280.1\|WP_096618055.1\|3919278_3921726_-\|NACHT-domain-containing-protein	gnl\|CDD\|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	7.68997e-107
NZ_AP018280.1\|WP_096618054.1\|3917947_3918454_-\|peptidoglycan-binding-protein	gnl\|CDD\|225943	COG3409, COG3409, Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane].	2.20081e-26
NZ_AP018280.1\|WP_096618052.1\|3915227_3915806_-\|dihydrofolate-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	9.96399e-27
NZ_AP018280.1\|WP_096618050.1\|3913976_3914489_-\|DUF1579-domain-containing-protein	gnl\|CDD\|377882	pfam07617, DUF1579, Protein of unknown function (DUF1579). A family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Sinorhizobium meliloti and Agrobacterium tumefaciens.	1.15177e-69
NZ_AP018280.1\|WP_096618057.1\|3923336_3923924_-\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.6832e-24
NZ_AP018280.1\|WP_096618047.1\|3910151_3911765_-\|magnesium-protoporphyrin-IX-monomethyl-ester-anaerobic-oxidative-cyclase	gnl\|CDD\|131081	TIGR02026, BchE, magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase. This model represents the cobalamin-dependent oxidative cyclase, a radical SAM enzyme responsible for forming the distinctive E-ring of the chlorin ring system under anaerobic conditions. This step is essential in the biosynthesis of both bacteriochlorophyll and chlorophyll under anaerobic conditions (a separate enzyme, AcsF, acts under aerobic conditions). This model identifies two clades of sequences, one from photosynthetic, non-cyanobacterial bacteria and another including Synechocystis and several non-photosynthetic bacteria. The function of the Synechocystis gene is supported by gene clustering with other photosynthetic genes, so the purpose of the gene in the non-photosynthetic bacteria is uncertain. Note that homologs of this gene are not found in plants which rely solely on the aerobic cyclase.	0
NZ_AP018280.1\|WP_096618051.1\|3914587_3915037_-\|VOC-family-protein	gnl\|CDD\|225356	COG2764, PhnB, Uncharacterized protein conserved in bacteria [Function unknown].	5.17874e-37
NZ_AP018280.1\|WP_096618056.1\|3922459_3923098_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	4.26698e-61

>NZ_AP018280.1|WP_096618053.1|3916041_3916575_+|hypothetical-protein
MPKLNVKQKNWLLSAHVAFGSIWFGTALCMVAIALKNTHTTNGDELYAINATLKLLDDFVIIPSANLSLLTGGLLCWLTIWGFFKHYWVIVKWIATVTLISTGTVWLGPWLNAATSISDIERSQAFSNPLYTFDIKGVLIGGAIQTLCVLAIIGISVLKPWGRRIVKSPEESTSSST
>NZ_AP018280.1|WP_096618052.1|3915227_3915806_-|dihydrofolate-reductase
MRELKYYIACSVDGFIAHKDGSFDGFLMSGEHIAGLAETFPETFPAHFRDGLGIQSENKHFDVVLMGRKTYEIGSKVGITNPYPQMKQYLFSRSMEASPDENVELVSTNAIAFVKSLKQENGKDIWLCGGAELAASLFQENLIDELILKVNPFLMGSGIPLFADVVKQTSLELSDRQIYDNGVLVLYYRIQC
>NZ_AP018280.1|WP_096618051.1|3914587_3915037_-|VOC-family-protein
MSVKAIPEGYHTVNPYLFVEGAANLLEFLKQGFAATEIRRTLHPDGSIMNAEVKIGDSAIMVSEARYDFKPIPSSIYLYVEDTDTTYENALQAGATSVMEPNDEFWGDRHAAVKDPTGGYWWIATHQEDISSEEIDKRIQVLFGSKEKV
>NZ_AP018280.1|WP_096618050.1|3913976_3914489_-|DUF1579-domain-containing-protein
METSTVQPELTMKAELQKEHQWLAKLLGEWTYEIEVTMEQDSPSEKSTGTESVRSLDGLWIVAEGQGNMPECGAVTTIMTLGYNPQTKRYVGTWIGSMMTHLWVYDGELNADETVLTLDSEGPAMSGEGKMAKYRDLLVFKSDDYRVLTSHVLGDDGKWHGFMTAHYRRK
>NZ_AP018280.1|WP_096618049.1|3913407_3913878_-|DUF1772-domain-containing-protein
MFALKLLALLGCGLMAGVFFAFSTFVMTALARLQPSEGITAMQAINITVINPLFMGVFLGNAVACIFLVIFSLSKWHQPGTVYLLVGSLLYLVGTLGVTIAFNVPMNDALAKVEPGSTDGTSLWTSYLVNWTFWNHVRTFAALAAATSLAIALRVI
>NZ_AP018280.1|WP_096618048.1|3912168_3912882_-|pentapeptide-repeat-containing-protein
MNVDEILKRYAAGERSFQRVNLLEAELTSANLQGADLSYADLRQTRLGKANLSQACLWEANLSEAILWGIDLSGANLHRAFLREADLTGAKLVKTLLDGANLVKASLCGVNLNSANLSNSLLLQADLRPSANQRTDLGYAVLTGADLSYADLRAVSLSHANLDEAKLCRANLSQTMQWGDLATDLTEASLKGADLSYANLTNAILRNANLQAADLTGAILTGADLQGAIMPDGSIHN
>NZ_AP018280.1|WP_096618047.1|3910151_3911765_-|magnesium-protoporphyrin-IX-monomethyl-ester-anaerobic-oxidative-cyclase
MRIMMIQPNYHSGGAEIAGNWPPSWVPYVGGALKKAGFTDIRFVDAMTDYIPDDALAEIIAQHQPDVVLATAITPMIYQSQTTLKIVKEVCPQAKTIMGGVHPTYMYNEVLHEAPWVDYIIRGEGEEITVNLLTAIANSTDEQERKNILGIAFLEDGQVVATPAHPPIADLDTLTPDWNLLDWSKYIYTPLNVRVAVPNYARGCPFTCRFCSQWKFWRKYRSGTPKKFVDEIETLVKEHQVGFFILADEEPTINKPKFIDLCNELIERNLGVHWGINTRVTDILRDEHELPLYRKAGLVHVSLGTEAAAQLKLNLFRKETTIEQNKRAIQLLKQNGMIAEAQFIMGLENETPETIEQTYQMALDWKADMVNWNMFTPWPFSELFQDLGDRVEVRDYSQYNFVTPIMKPEAMEREDVLKGVLRNYARFYLRKTLEYWFVKDPFKRKYLLGCLKAFAQTTINKRFYNLKRVKYNGLQTKVELGFDESKILTREQIAQLKQEHPELNADVDFAGNISACGAPSDLPEYDEGGQDVPSMKI
>NZ_AP018280.1|WP_096618046.1|3908988_3910065_+|magnesium-protoporphyrin-IX-monomethyl-ester-(oxidative)-cyclase
MVNTLPQSAPKQPKQGIKAPSKETVLTPRFYTTDFETAASLDLSDQQSELQAMLEEMRADYNRHHFVRDEEFEKSWEHINGEARKSFIEYLERSCISEFSGFLLFKELSRKLKQRNPLLAEIFNLMARDEARHAGFLNKAMGDFKLSLDLGEVTKTRTYTFFPIEWVIYSVYLSEKIGYWRYIIIYRHLEKHPENQFYPIFQKFESWCQDENRHGDIFKALLRSQPQLWNNWKARLWSRFFLLSVFATHTITVHERAGFYHSLGLDATEFDRQVVEKTNETAGRAFPVMLNTDHPKFFPLLHQCSDYNFQLAEIERSSQPKFIKLIRKLPFLGAIVWNLLLIYLIKPIDTEKLRGTVR
>NZ_AP018280.1|WP_096618045.1|3907545_3908661_+|hypothetical-protein
MEKMHPWLSKKKNRDKHGHMQASTSNPGMSWEEAREVFEEIVGWLDSDSICGLEHGEIESKLLDNGYELLRRLLQGYFDKRLTKGEKANAKRMATVASVYTINPFVRTVEQIVNPSDKDKKIKRPKPIGKRVWASVAKEPEVVIKEAFDEVLHRDRDRQKRLIALVDGNKQQLSLMKKFAKKHNLELTIVLDIIHVIEYLWKAAFVFYSSTDKQAEAWVTKRLQYILEGKSSDVASGMRTSATKRKLTPQERKPVDNCARYLLNNREYLKYHDYLKAGLPIATGVIEGACRHLIKDRMDITGARWSLAGAEAVLRLRSLYISGDWDKYWRFHLHQEHKRNHLALYQGAIPLMKQVAKACCPITPPPLPIPG
>NZ_AP018280.1|WP_096618044.1|3906448_3907210_+|heme-oxygenase-(biliverdin-producing)
MSSHLDICLREGTKDSHTMAENTAFMKCFLKGIVERSFFRKLLADLYFVYSALEEELQRNQEHCVMGLIYFPELNRKTNLEKDLAFYYGENWQEEISPSSAGQVYVNRIREIANTQPELLIAHAYTRYMGDLSGGQALKKIARSAMDLPDDQGTAMHEFEQLSTPEAKRVFKDKYRQALNSLPLDEAMIEKIVNEANYAFALNRDVFHELEADVKAAIGEHVFDLITRQDRVGSTERHSPKSDVEVITPEYSI
>NZ_AP018280.1|WP_096618559.1|3917383_3917872_-|hypothetical-protein
MKKISKSIFLSSLVGLTLGFYPNLAIQHANAQTTKSCSPSRLNSSYRKIGELPILEAKTNGASYSSTAYSAGNNRFAYLVLDSAKKTAARVDLTYSVDKKGRNIANIRVCGDVQNSSELPLLKFNFLRGKSIGVYTLGTQNLTYVVPRASHTTTIQTVIDAT
>NZ_AP018280.1|WP_096618054.1|3917947_3918454_-|peptidoglycan-binding-protein
MTSTTESVAKLNKPVLKEGSQGAAVKELQKLLFDKGFYDNCRKEVDESIIDGIFGIMTTSAVRSFQAHVFLPVDGVVGDRTWRALFKNAPVDMPTLKLGSKDVGLVKIIQQKLIFSGDYQGIIDGVFGAKTEAAVKALQKRTRLTVDGIVGDRTWFELSKIRNPEGGC
>NZ_AP018280.1|WP_096618055.1|3919278_3921726_-|NACHT-domain-containing-protein
MNKNRSKVSATPKGLTKATNALKRHYETKLNLANNLTGLVGRNTIQNFFQGKAIQIDKFKEICKALKLESDWEEIAGLDNSPDLIAEPCNEATKTDVEEADISIDIDSLVQEVREKLKGYIQERCGTMRVLDMTQPIGLGDIYTDVNILEKITGRRGLDIPELLQNLKIELDEFDRFGLGKVTEKRIPGLEAVENHAKLMVLGKPGAGKTTFLKYLAIQCINKNFQENRIPIFITLKQFAENPLDLQDCIVQQLGNNVIKNTQIIQLVKSGKFLLLLDGLDEVKEEDISKIINLIKEFSERYPTNQFVITCRIAAREYIFEKFTDVEVADFDERQIKIFVSKWFQNKEPDAPERFIQQLESNNPIKELATNPLLLTLLCLEFEDSGDFPSDRAELYNRAIHTLLRKWDSKRGIVRDGGDEVYKKLSVGHKEDLLSEIAWTTFKDSNYFFKQRDIEGYIKDYIRNLPEAKTDPDALRVDSETVLKSIEAQHGLLVERARGIYSFSHLTFHEYFTAREIVYGSSQENALKILASYISEKRWREVFLLTVGMLKSADKLLQLMKQQIDTSLAGDQKLQQFLTWIQEKVCSMETQYKLAAVRAFYLYLYISLFLDRSLDRSFEFYISLSLSLSPLSLDRTLSPLSLDRSLDRTLSPLSLDRSLDRPFDLDLYLSLSLSLSFSLSLSFSLDLDLESFSQTVSRTFEQTLSLKRTHNSELHRSLQELKNQLPDYKVDKKVDEEALKYWWLENGQVWAEKLRSVMIEHRNIGHDWQFSESQKKLLQQYYDANKLLVDCLNRSRYVSREVRQEIEDTLLLPVS
>NZ_AP018280.1|WP_096618560.1|3921956_3922226_+|hypothetical-protein
MPNTNSEIELSIAQERLRQAQYSFNLALIATALSACISLLGAGLLLSGKVPEGTVTAAGGMAASIRCIQLAKDSNDRLDKILPELKDED
>NZ_AP018280.1|WP_096618056.1|3922459_3923098_+|histidine-phosphatase-family-protein
MTLNLYFLRHGETTFSQSGNFCGQTDAELTSEGIQMAHSFADVYQKLKWEAAYVSPMKRTVATAKPFCDAIGMDMQLRDGLREGSYGKWETKSKSFAQENYGDNYVKWLTEPAWNAPLAGETAVEIANRSMPVIAEIQDKYPQGNVLVVSHKATIRIMLCSLLGIDLGRYRYRVNILVASVSMVKFDVNGPLLEILGDRHHIPEHIRSRPGT
>NZ_AP018280.1|WP_096618057.1|3923336_3923924_-|Uma2-family-endonuclease
MVQSPNKRLTLEEFLALPEGDVTYEFVNGAAVPKYKDDEMSPKFFHSRFQKTLLILLDQCLRSNGRVEVEWAIKLKINNQDWMPVPDLTYVSYNQLPADWLKDEPCPVPPELVVEIISPGQTFGEMTEKATDYIQAGVARVWVVDTKARTITIFAPACIPTTYRDDRLISDDLLPGLEIPANEVFQRAGLIGSNS
>NZ_AP018280.1|WP_096618058.1|3924130_3924475_-|hypothetical-protein
MNLFNRITLLKKLAVLAVATGISFLISMPVLAQTNPRPSIFKEFPYNRSSNHRTRQRPKRTLKHRPNARLKKQPTSAQNYRKRVPQESSEAPRSYDFRAPGYKLPAPVPSKRSR
>NZ_AP018280.1|WP_096618059.1|3924616_3924961_-|hypothetical-protein
MRILLIANTIFEIGIGCVFLLFPSLVLKDSALSISLLRIIGCGALALGTLSLLMLNVTDKKALKPGLIALSIFHTLAAASQIYSFSSGTANITIIIIHSLFAAFFVCISWQQVR
>NZ_AP018280.1|WP_096618060.1|3926045_3926270_-|hypothetical-protein
MLEIAWFATRLFIKGQLLRDPVDFIKKIVFGTVIGLTLFLSLAQTEIPLGLAVITSSLITGIVMPYLFRDFKMK
>NZ_AP018280.1|WP_096618061.1|3926282_3926546_-|hypothetical-protein
MEEIINDPLIHKLIVSLTADEVNFFTGMIWLIVGTFISMAGGAIGGLLIARKDLGYELSAILGGFFGPAGVIPTILLGLAILNILAQ

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Crispr_ID: NZ_AP018280_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_7

4007284-4007377

Orphan

Consensus_repeat	Method
CTACCTTGCTTCCGCATAGCGTTACTACAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_7

>merge|NZ_AP018280|7|4007284-4007377|CRISPRCasFinder
CTACCTTGCTTCCGCATAGCGTTACTACAAACTAAAAACCACGAACTACGAACTACGAATTACCTACCTTGCTTCCGCCTAGCGTTACTACAAA

>NZ_AP018280|7|7|4007284-4007377|CRISPRCasFinder
CTACCTTGCTTCCGCATAGCGTTACTACAAA	CTAAAAACCACGAACTACGAACTACGAATTAC
CTACCTTGCTTCCGCCTAGCGTTACTACAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096614752.1\|4020938_4023704_-\|integrase	unknown	unknown	gnl\|CDD\|366234
NZ_AP018280.1\|WP_096614753.1\|4019742_4020939_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379165
NZ_AP018280.1\|WP_096618117.1\|4016588_4016849_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096614754.1\|4017974_4019543_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377670
NZ_AP018280.1\|WP_096613165.1\|3995098_3995653_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|223340
NZ_AP018280.1\|WP_096613163.1\|3994112_3994976_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NZ_AP018280.1\|WP_096618110.1\|3997463_3998351_+\|DUF1186-domain-containing-protein	unknown	unknown	gnl\|CDD\|369037
NZ_AP018280.1\|WP_096618116.1\|4016139_4016355_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235840
NZ_AP018280.1\|WP_096618114.1\|4008431_4010558_+\|DNA-helicase-UvrD	unknown	unknown	gnl\|CDD\|223288
NZ_AP018280.1\|WP_096618108.1\|3996089_3996473_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096613161.1\|3992607_3993672_-\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|234988
NZ_AP018280.1\|WP_096618113.1\|4006885_4007236_+\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|183395
NZ_AP018280.1\|WP_096618565.1\|4002897_4006785_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|274377
NZ_AP018280.1\|WP_096618112.1\|3999769_4002661_+\|helicase	unknown	unknown	gnl\|CDD\|350769
NZ_AP018280.1\|WP_096618111.1\|3998484_3999393_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|224629
NZ_AP018280.1\|WP_096618109.1\|3996870_3997383_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618118.1\|4016848_4017139_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618115.1\|4010604_4016073_+\|DUF1998-domain-containing-protein	unknown	unknown	gnl\|CDD\|350681
NZ_AP018280.1\|WP_096614751.1\|4024101_4024293_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096618119.1\|4024436_4024826_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096614752.1\|4020938_4023704_-\|integrase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	3.78596e-11
NZ_AP018280.1\|WP_096614753.1\|4019742_4020939_-\|AAA-family-ATPase	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	4.7627e-06
NZ_AP018280.1\|WP_096614754.1\|4017974_4019543_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	2.47946e-15
NZ_AP018280.1\|WP_096613165.1\|3995098_3995653_+\|dihydrofolate-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	3.87513e-19
NZ_AP018280.1\|WP_096613163.1\|3994112_3994976_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	3.00215e-08
NZ_AP018280.1\|WP_096618110.1\|3997463_3998351_+\|DUF1186-domain-containing-protein	gnl\|CDD\|369037	pfam06685, DUF1186, Protein of unknown function (DUF1186). This family consists of several hypothetical bacterial proteins of around 250 residues in length and is found in several Chlamydia and Anabaena species. The function of this family is unknown.	2.5102e-121
NZ_AP018280.1\|WP_096618116.1\|4016139_4016355_+\|hypothetical-protein	gnl\|CDD\|235840	PRK06599, PRK06599, DNA topoisomerase I; Validated.	0.00421659
NZ_AP018280.1\|WP_096618114.1\|4008431_4010558_+\|DNA-helicase-UvrD	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	3.4623e-17
NZ_AP018280.1\|WP_096618113.1\|4006885_4007236_+\|four-helix-bundle-protein	gnl\|CDD\|183395	PRK12275, PRK12275, hypothetical protein; Reviewed.	7.59657e-34
NZ_AP018280.1\|WP_096613161.1\|3992607_3993672_-\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|234988	PRK01889, PRK01889, GTPase RsgA; Reviewed.	0
NZ_AP018280.1\|WP_096618565.1\|4002897_4006785_+\|restriction-endonuclease	gnl\|CDD\|274377	TIGR02987, m6_adenine_and_m5_cytosine_DNA_methyltransferase, type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family. Members of this family are the m6-adenine DNA methyltransferase protein, or domain of a fusion protein that also carries m5 cytosine methyltransferase activity, of type II restriction systems of the Alw26I/Eco31I/Esp3I family. A methyltransferase of this family is alway accompanied by a type II restriction endonuclease from the Alw26I/Eco31I/Esp3I family (TIGR02986) and by an adenine-specific modification methyltransferase. Members of this family are unusual in that regions of similarity to homologs outside this family are circularly permuted. [DNA metabolism, Restriction/modification].	3.86458e-13
NZ_AP018280.1\|WP_096618112.1\|3999769_4002661_+\|helicase	gnl\|CDD\|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.15632e-64
NZ_AP018280.1\|WP_096618111.1\|3998484_3999393_+\|restriction-endonuclease	gnl\|CDD\|224629	COG1715, Mrr, Restriction endonuclease [Defense mechanisms].	8.75179e-134
NZ_AP018280.1\|WP_096618115.1\|4010604_4016073_+\|DUF1998-domain-containing-protein	gnl\|CDD\|350681	cd17923, DEXHc_Hrq1-like, DEAH-box helicase domain of Hrq1 and similar proteins. Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.72064e-60

>NZ_AP018280.1|WP_096618113.1|4006885_4007236_+|four-helix-bundle-protein
MENNVAITDRTKLFAIRIIKACCFLDEKPGVYRTLSKQLLSSGTSVGANVREAQSAQSDKDFLHKLEIALKEARETQYWLEILIESDLIDKPKFEPLLQEANEIGKILVTSTKNSN
>NZ_AP018280.1|WP_096618565.1|4002897_4006785_+|restriction-endonuclease
MATAWGDAKAYWAAFQRKLARLPEDDTATTITREWGVSLLESLGYKPVLTRQAEDVDGQSYAISHRALTPKDSITNYVSEAPPQEALRTTNCELRITNYPPIHIVGCRLKLDQRPPSGIPRLSAHGLVQEYLNKTEHLWAITTNGYRWRLLRDSSLMTRLSYVEFDLEQILNGENFAEFGIFYRLFHRSRLPEDVDDADKCLLEFYHQETLQQGGRVRDKLRDGVEEALRIFGNGFIQHPDNEHLRQKFSDNYELRITNYELKFYRQLLRLIYRLLFLMVAEARELLLIGEDVEKGRIYREYYSVERLRRLAEKPSYRREGFQDLWRGLCVTFKLFDENWRGQVLGLSPLNGDLFGSNTLPDIDNCAIDNYDLLQAIKHLSLYVDKNGLRRVNYASLDVEELGSVYESLLDFHPQVRVNQEIYEFVLVYGSDRKTTGSFYTPPQLVQQLIKTALEPVIQERLSRSQSAAGNASPEALPPGKIEVEPQKLRYHAGSSNEDKEKALLSLKIVDPACGSGHFLLAAARRIGKELARVRTGETEPGKEPLNLAIRDVIQNCIYGVDLNPLAVDLCKVALWIEGFYSGMPLNFLDHRIKCGNSLVGVLDLEVLKEGIPDEAYKAVTGDNKTLSTQLKKRNKKERENQGQLTIFDNLETERSEYIENARVLGEIAETTPQEVREKQARYKQSRNQEKNPGWWRDFSACNLWTAAFFMGLTEENLQLLPTSAALSQLLRGNSSTQKVVDAANKLAEEKRFFHWCLEFSEVFEQGGFDCVLGNPPWERIKLQEKEFFASRSADIANAANKAAREKLIKELAKKNPELAQAFDDAKHDAEAQSKFIRESARFPLTAVGDINTYAVFAETTRNLISTEGRVGVIVPTGIATDDTCKKFFGDLTQKQALASLYDFENKENLFPGVGHGRYKFSLISISGKAVKVADLAFFLTQPRQLENQVRIFQLSSKDIALMNPNTLTCPVLRTSTDAELTKKIYQHVPVVENERTGKNSWSISFMRMFDMANDSGLFKNEDGENLLPLYEAKMFWYYNHRFGDYADYPKGALTSHLPDIPEKRFENLNYYIKPRYWVSKAEVENRLASNWNYNWLIAFRNISNATNERTAIFSILPKVALAHSSTVLTIAQEKVVVVSCLLGNFSSLVFDFVTRQKMGGTNFSNFILKQLPLLPPEFYTQENIQFITPRVLELVYTAWDMQPFAKDMGYDGEPFIWNSNRRAILRAELDAYYAKLYGLTRDELRYILDPADVYGADFPSETFRVLKNNEIKQFGEYRTQRLVLEAWDRIIRNS
>NZ_AP018280.1|WP_096618112.1|3999769_4002661_+|helicase
MTDTLDRKEKQTIQPGSIVRCRDRQWVVLPSENLDVVRLRSLSGNEDEITGIYRHLLETNLEAIASASFPLPSANQVKDHAAAHVLMDAARLLLRSGAGPFRCLGRLSLRPRPYQLVPLLMALRLETLRLLIADDVGIGKTIEAGLIAREFLDRGEVKRIAVLCPPHLCDQWQQELRENFHIDAVVIRSGTASKLERVVPGDEHIFSYYRHIIVSLDYAKADRRKASFITHCPDLVIVDEAHTCANGNKKSTSQQQRHQLIQEIAAKADRNLLLLTATPHSGIEEAFLSLLGLLKPEFGQLSLDFLTEEQRKTLAQHFIQRRRADVKLWLGNETPFPERESAEMPYKLSKEYKSLFEDVYNFARGLVKTTTSDMSYAQRRGRYWSALALIRCVMSSPAAAIATLSKKGNRESGMGIGEDSPVIDEDLMSSYVYDPADREQATDAAPTMVVEQGQESYGEKERRKLREFVKAAEALQGKKDSKLQACIETVESLLQDGHNPILWCRYIATANYVAEALRQKLEKKKGEIRVIAITGEQSEDEREIRLEELKSYPQRILVATDCLSEGVNLQSHFNAVLHYDLPWNPNRLEQREGRVDRYGQPAEKIKTFLLLGQDNPVDGAVMDVLVRKAVQIHKTLGITVPVPMDSTNVSEAVFKSLFDKATDVVQLSLLDLLDGEESAVELVHSSWDKAVEREKISRTRFAQRSIKPEEVQQELMDSDQILGSQEDVERFVKSACDRLNCSLINKKLGKWLLPSIPNFLKSGLGEKPLLLTFTHPAPSGVEYIGRNHPLVEGLARHILEDALVNQDNPIAARCGYTVTDAVEKRTTLLLVRLRHLLEAKSSKQQRTGSTLLAEECAVIGFTGSPSQPKWLEPEIANDLLQQSSPVSDTPKVIKQEEIGELLEDIGELEGDLEKFAIERSHKLSQSHKRVRSITKEGAIQVQPQLPLDILGVYILQPGGKKGS
>NZ_AP018280.1|WP_096618111.1|3998484_3999393_+|restriction-endonuclease
MALPDYQEIMLPLLGFVADGGEHSSRESVERMAEYFTLTEQERRELLPSGRQYTFDNRVGWARTYLKKAGLLESTRRGYFRITQRGQEVLKQNPTRIDARFLEKFPEFIDFRNSKPESGTVGVDENATNSQTPEELIEAAIQQLNQELAIEILDAIKACSPAFFEKLVVELLLKMGYGGTRKDAGQTVGQSGDGGVDGIINEDRLGLDVIYIQAKRWDNSVSRPEVQKFAGSLQGLRARKGIFITTSSFTREAKDFVEKIDSRIILIDGDRLTKLMIENNVGVTALAAYEIKKIDSDFFSDT
>NZ_AP018280.1|WP_096618110.1|3997463_3998351_+|DUF1186-domain-containing-protein
MEVAEIIKQLEYNDTGIFPREALESAIAAQSAITPVLIQTLKDCKNNLDELLDDSSYFLNIYALYLLAKFREKEAYPAIIDFFSTPGDAAIDSTGDVVTEDLGRIIASVFDGNLEPIKQLIENREANEYIRGAALDSLITLIAQNMIEREQVVEYFAELFQGKIERIPEDYLINKLVVDACDLCPIELKSHVEQVFEDGLIDQMFIGREEVDEAIELGIETSLKKLRQDSHHTFVDDVIEEMEWWACFHQANTKKSYQPFSITEELTKSPHRKKSQGAKKKKMQKQSRRQNRKKK
>NZ_AP018280.1|WP_096618109.1|3996870_3997383_+|hypothetical-protein
MLDLIRIQTLAQTYSPQEMFAALVWQRRFNNFYGDRVITDLFQNPHLWCSFLFTKPIFAPDENGLSFGGVIDTLLAMANYRPMPEDSIIHFVNYPADTLHILTENQDTKVSQLVNFGKKWRADSVDVTDGTDENYAYRLKRQLRYRLEEALWEEESFAGKDAVVISYWWD
>NZ_AP018280.1|WP_096618108.1|3996089_3996473_+|hypothetical-protein
MPGQKILSGNFAKINRYVEDIEQVNSISLEDSHEDNFSGGAAEEVEVVSTSDKQNKSEIREICTELKRLRINPEQCLGVIKKHWENVAGALARVKEAINEGWCNNPTGLFKLKRTYFVSPKTLQQDF
>NZ_AP018280.1|WP_096613165.1|3995098_3995653_+|dihydrofolate-reductase
MKTQYYTATSLDGFIADDRNSLDWLFQFGEMEGDSYGNFLRDVGAIAMGSTTYEWILAHHINEDAEKPQKWMYEQPAWVFSSRNLPAIEGADIRFVSGDVRAVHQQMVTAAGDKNIWLVGGGDLVGQFYDHGLLDEIIVTVASVTLGSGAPLLPRKIITPPLKLLSATTYGDSFVELCYQVRDR
>NZ_AP018280.1|WP_096613163.1|3994112_3994976_+|aminoglycoside-phosphotransferase-family-protein
MSAKFDRYGLTTRAISASVAVAKQYGIEVDEPKIIADAYSVRVHLQPAPIAARVSTITSILRQPITTWLQRELAVVGFLHSQGVPVVPVSDLLPVDVHCHDGLFMTFWQYISPLDVVPDSETVGKMLAELHPVLQNYSGDLPLLAPPLNDIPRGIARLQEIGDILNADDLNLLRETYDRLLPRLENPGGLLQPLHGDAHAGNLIATAKGFLWNDFEDTCRGLVEWDLVNIDDVGRTAYGEIVEPEMLEIYQQLRKLHGIVWVYALSPEFPDWLEYVRSLLDDLRGDR
>NZ_AP018280.1|WP_096613161.1|3992607_3993672_-|ribosome-small-subunit-dependent-GTPase-A
MNLELWGWNDFFANHFEPYRQQGFSVARVIIECRNSYILQSENAELSAEISGKLRYRASDARQDFPAVGDWVVIRAREKGGTATIHEILPRKSKFSRKAAGAETREQIVATNIDTVFLVSGLDGDFNPRRIERYLILAWESGANPVIVLNKADVCPNLEKCLTEVESVALGVPIITISATIDQELAALRSYLQPGQTVALLGSSGVGKSTITNQLLRETVQTVQTVRQGDSRGKHTTTHRELMRLPTGGLIIDTPGMRELQIWSGEEGISGSFADIEELAGQCRFRDCQHEREPGCAVRQALQDGSLDESRFANYQKLQKEIKYMERKQDQREYIAEKEKWKKITKSMRNYQKG
>NZ_AP018280.1|WP_096618114.1|4008431_4010558_+|DNA-helicase-UvrD
MRLRSAISVTDTFLNELLNLPQSISKKVTKAIKILEKDPISAQGNAKKLKGYQNNIYRIRIADYRVFYSFGQGWVKLLSVRKRDERTYETEIPQFDIPSPPPDEVIIEEEIVSIPVIPPSENTSRNINDSPNLISNSFLTTPLPLKFNPSLLQQWRIPSEYWQDILKVENAEAILELPIPDRLIARILDNLYPRPIEEIAEQPEYLLADVEDLDKFFTGDITAFLLKLDPEQEKLLDFRRDSAVLVKGGPGTGKSTLALYRVKKLVDSGCSAILFTTYTNALVTYSQQLLTQLLGQAPETLGVEVSTVDSLIYSFYIQKYKNQKYKKPKFASEQDCLKYLQAAISQTKIPTKNVFESRVIAQTLEKLGVNYLLQEIQTVIQAWGISSVEAYMQTPRQGRGTPLKTNIRKVIWLIYQTWIALMAQNGLTTWEQVRSQALTLALESSTKPYQAIIIDEAQDLSPVALRFLLTLTSNLNGVYFTADASQSLYQRGFNWKQIHSELKFTGRTLVLKRNYRNTPQIINACTNILADTEAGDRESLHQEPSPHQGDLPTLLLVDSCDEEIQKIREFFIRYAQKFRLPLHGGAVLCTTNYAGKTYAEKLTQLGLKAEFVTGKNIDIKAHHIKVLTLHSAKGLEFPFVVIVGLERDNIPCINKNLQPEEITATINEQRRLFYVGCSRAMRALMVCASQSNPSEFVDSLKRENWLSI
>NZ_AP018280.1|WP_096618115.1|4010604_4016073_+|DUF1998-domain-containing-protein
MKIPVKLQELLQQPETAITSISALIGQGLALVDCSGVDTVTLEFLDLLFANIPQDWDFMQIAEVIDSTTLIDTFALQLSDYIDRRSGRTPDNTINRDGGAIASRGVETLQTTNYLDIFQFRNEVIGDYRQYIESFLKIRNQKVKEFVDKELDKGQLWTDPLVQLNPKYKAGATVRELVKQNILHQDSEKYFCTKEGKPFTFHYHQKQAFETAKSQQPYVVTTGTGSGKSLTYVVPIINDLLHNPDIRGVRAILVYPMNALINSQEQELRKFLDNVPNTHIRVEKYTGQESLERKTQIQNNPPQILLTNYVMLELMLTRSHEDILVASPHLKFLVLDELHTYRGRQGADVSILIRKLRQRSQKLRATDNKLLCIGTSATMSSKGTRQERRQVVAEVASKLFGVEIQVSNVIDETLEPSIQRSEPSIEELRECLEKGLPPESERSLEEFEKHPLAAWIEMNFGLEREEEKRREGQGEVYDISTKRSLNYLRRQPITLEEGAEKLAQILSQGDVDALKRYYEQSLNILKQMFLWGSKTKGLAFRLHQFVSQGGSVYATIEPHDIRSLTLDGQYSTTNNRLLFPLVFCRECGHDYYVVRYDANNHTVVPQLPTMLEAPDDDENVQDGYLSLDETGLWDYNDEERLPDSWFRETKRQGRVVKKEYERFIPRKIYVLANGKVSTSPLEGTPCWFIPKPFRTCLNCGVLHDAKKNEFSKLSRLSSEGRSTATTLLSLSTVNRLKQVYTDEKAQAAKILSFTDNRQDASLQAGHFNDFVQTSFLRAALNRAIQENQELTHKQLATTVVQYMGLSQSDYASTPAEVGIGKRNNENAFRDLIEYRLYEDLRRGWRIIQPNLEQCGLLTMKYMELEEVCQNDKIWQKYRHPILLQATPSDRYNAAKIFLDQLRKELAIDAEILQPEGIEQLRREVTQALKEPWKVERYEYLHSAKWATTDTKNNKYNKFSIIKLTARSKIGRFLRSHSAWDWLLQPLTEEQYNELIAALIGVLKDAGYLSEQPQGVQLKINALAWIASQLQQIPADPLTSKRLQGDENTDIPINSFFQNFYQNNAHSIKSMEGREHTGQVSSKDRQEREDDFRNGKLAALFCSPTMELGIDISDLSVVHMRNVPPSPANYAQRSGRAGRSGQEALVFTYASIGSGHDQYFFKRQNQMVAGVVAAPKLELANQDLIKSHIYSVWLARTGMQFGESMNQILDLEVEGYPLKGSIRTQLTLTQHQLDECLEAIASILEDKFCTDDLKKVSWYSPDWLKFTLDNAIAAFDRACDRWRKLYSDGVSQLEKSRLIIDRSARGNSTQEERDKADAEQKEAQRQIDLLVGNLQTKNQTQFEFYPYRYFAAEGFLPGFNFPRLPVRAYIRTSPDSGEFISRPRSVALREFAPNNIVYYEGSKFMVTKTKIAVGGIENQYNRVSVCFNCGYFHPSDDRDICENCGVQIKPDINGNIAKISRLLPMETAITQRRDRITCDEEERLKYGYNITTHYRYSEQKRKTAIVHTSSGQAFLRLTYSPTANLWRINRGLKKNRDERGFKLDIKTGEWGDNGNNQSSENIHSEVHILVEDTSNILLVEPIGIDGEKNEALITTFQFVLETAIQAVYKLEPDELDSERLGQGKYLLFWEAAEGGAGVLSQLIEQPNAFQKIADAALDICHFKEPKDSCVQACYECLLSYRNQFDHPLINRHLVKPWLEELLESSVIWEIDEAVRQQQYQQLLALTDPKSDLERLVLAEIYHKGYKLPDTAQKLIPEANIKPDFLYQKEKIAIFCDGSVHDSPEKKKQDKIERNNLKYSHNYQILILRYDEEWVNKLAIFASL
>NZ_AP018280.1|WP_096618116.1|4016139_4016355_+|hypothetical-protein
MHNLPNSPVLRLNLTNTVKLLTTFLSLVPQKDPDSIEKRIEKGQNPLGNCPTCNGAMWLNQEKYGTYIACK
>NZ_AP018280.1|WP_096618117.1|4016588_4016849_-|hypothetical-protein
MQLKYRSFVGDISINKTQTPEVQPISSQLQEPEIIKHILIGSPKTVTTTMQVLQQLGYADIQNWSPLLATENPGEVMSILTRYITA
>NZ_AP018280.1|WP_096618118.1|4016848_4017139_-|hypothetical-protein
MAEVLSTPQFQVLTHQYTGEKTGRIYFPALFLAEFHECVTQWLQQQEILFNEADVKQYADGSFRLYFRVVNSWEREYFRLVNALMEKSISENKEKS
>NZ_AP018280.1|WP_096614754.1|4017974_4019543_-|XRE-family-transcriptional-regulator
MILKFKPLEIYDLGLPDIPKRSHLYHLKPIGISTPDVESLTGYIARLAQTHCMSTGQLICREVMPMLKPEYASDITDIYKNFLSEKESRAYNGTGLMASNVVNACQTLTGCNQLQFLTLLAFREVLYPKDLFRPFKAWCPICYQQWQMTGQVLFEPLIWSLNQVTICQHHLQSLQTNCPHCQKRMYFIEFHSRPGYCSKCGGWLGTPLISETQGLPEKEIESQLWIIRNVGKLIATVPNLSFTPKREIIAKSINDYINQLTPANQTAFAQICGISHGGLFKWITGNSIPTLTKALQICACLNIELIDFLNGQICELSNDIIVSLLTSHQQSKIRQYEEKPKRKPLGLRKIKQELLKALKEYPPKSVTDIRKRLGLKANSTFYYYFPEISRQISANYALYRKNDKHQQIENALFSQNYQDEYPPSSLTEVSKRIGIGIRALYEHFPEKCYEIAEKYAKYKLESALQKREEIRQQVRFAALQLHNQSIKPTSAKINQFLNNPGYMFKKTAQITLSEILHELGYK
>NZ_AP018280.1|WP_096614753.1|4019742_4020939_-|AAA-family-ATPase
MTNEYGFPPSLLEAPLEQRLLYFKNPNVAIMHQKLKIAFNKVFRTIHEPAGASIILVIGPSGVGKSTLLSLLEKKILLESIQQMSADPGWVPIVRVEALAPGKGTFRWKNFYKTILLAVDEPGIEQKIDYESDGISRNHQGRLMIGLKATEDSLRFSMEKALIHRHPYTLAVDEFQHIGKMAGAELLQAHMDCVKSAVNLTKVPWTGFGTYQLLNFLELSPQLSRRTKIIHFPRYSLDCDKDINEFLRVLEHLQLKMPLVQTPPLRQKYWEFCYERSIGNIGTLIGWLTDAYDLCISENATTLTFEHLQETAKSARECEQMASEAIQGEEKLIDNKYINKNLRAILGFDNSQTKMHKHDGLNSDDNQQVNNYKSRQKRKPFQRNPKRDKVGIRESEKS
>NZ_AP018280.1|WP_096614752.1|4020938_4023704_-|integrase
MMTSVGFDIWCTRLKLNEQAKKQIEQIRSSEPSRRVGGGINNVCGRYPSQKMGVTIQFESHRNELAHIYQLEYDENVLEYYDQPPPIFLDYLSKNGRRNYHRHTPDTFVIRKDSAGWEEYKTEKELIKKAQESPNRWQKTQDGKWLCPPGSEVASQLGLYYIVRSSSEINSIFLRNFIWLSDYFYNRKQLSVVDEVIQNVRTLISQKPEITLAQIIKQEIASIDDLNILIATNQVYVDLQSAFLGQPEQVRVYLDPEEALIYKNLASSQIIATGGDTSIKVAIGTYIDWDGIKWEIVNPGNKSIGLLGDNGNFIELPNNIFENLVKSRKIHGVANTEKLMTKTDIEEILKKASKEDLKTANKRFQEIEQFLSGITSKSTTRTQRRWIKNYQTAQRIYGRGLLGLIPKHHNKGWRRKSLEQEVFELMLSDIEENYENIKQPSIRHAYESFKEKCIANGFKAPSKETYRLTVRKRPQHQLQSKRMGSRAAYKEEPFYWYMHLEGTPTHGDRPFEICHIDHTEVDVELLSSIMLKYGVCESSLSESEQLEQINMGRAWATLMIDAYSRRILAVYMTFDPPSYRSNMMVLRICVARYGKLPQIIVVDCGTDFDSTDFETLLAYFGITKKQRPPAKPRYGSVIESFFGVADKEFWHNLMGNTQIMKNVRQVTSSVNPKNNAIWTLPKLYAYFCEYCYEVYDNCPHPGLRMSPREAFNIGNANAGNREQTLVNSEEFKLVALPSVTTLAGKRKVTQDGVKVNYIYYWHSSFSLIRGKKVDVKYDPFDITVAYAYVQGEWVQCQSRYIWELSGHSVRELMIAASELRKLNKLQNYQFGDVTAKKLAGFFKRIEMEESLLTPAWLQAKKAVQQQHLKDAELKQVIAFVSENPIHPEQQPTLLATETKVQLSEVVVSEVINETFEPLEEW
>NZ_AP018280.1|WP_096614751.1|4024101_4024293_-|hypothetical-protein
MLRNGYVVWEGASLIDGSPIVLILTGFVNPTSNRKTGRQLQSWILSQNYVLRQQLLCVRNDKQ
>NZ_AP018280.1|WP_096618119.1|4024436_4024826_-|hypothetical-protein
MATRKQSTTNFQTIDNSILGEYAVSDYSERVYSKVYYSIRSLCGLVAKRSLKETFSWDEFKERFANDFGKVEEKRYSLEQLLEYANRKFGKTLEDLLTEHDISWQRRREYMERNQVDIQTEVVAESTNY

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Crispr_ID: NZ_AP018280_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_8

4659193-4659592

Orphan

I-D,II-B

Consensus_repeat	Method
GTTTC----------AATCCCTGATAGGGATTATTTTTAATTGCAATA	PILER-CR
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT	CRISPRCasFinder
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	CRT

5 spacers

The CRISPR arrays of NZ_AP018280_8

>merge|NZ_AP018280|8|4659193-4659592|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATATAATCTAAATCTTTATTTAATTTAGAAAATAAGTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATAGAAATTAAAGACAGTTTATTGTCTTTTCTTCCTGTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATAGACACGCGATCGCAACGTAACTCTAAGAGAATGGAAGGTTGGTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATAATGAATCACGCACAGATGATGCTTTCTTAGGCAGTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATTTTTTATTGCCGAATAATATTCTTAGGGATAGCCGTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA

>NZ_AP018280|8|5|4659193-4659592|PILER-CR
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	TAATCTAAATCTTTATTTAATTTAGAAAATAA
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	GAAATTAAAGACAGTTTATTGTCTTTTCTTCCT
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	GACACGCGATCGCAACGTAACTCTAAGAGAATGGAAGGTTG
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	ATGAATCACGCACAGATGATGCTTTCTTAGGCA
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATT	TTTTATTGCCGAATAATATTCTTAGGGATAGCC
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA

>NZ_AP018280|8|8|4659193-4659591|CRISPRCasFinder
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT	ATAATCTAAATCTTTATTTAATTTAGAAAATAA
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT	AGAAATTAAAGACAGTTTATTGTCTTTTCTTCCT
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT	AGACACGCGATCGCAACGTAACTCTAAGAGAATGGAAGGTTG
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT	AATGAATCACGCACAGATGATGCTTTCTTAGGCA
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT	TTTTTATTGCCGAATAATATTCTTAGGGATAGCC
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAAT

>NZ_AP018280|8|5|4659193-4659592|CRT
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	TAATCTAAATCTTTATTTAATTTAGAAAATAA
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	GAAATTAAAGACAGTTTATTGTCTTTTCTTCCT
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	GACACGCGATCGCAACGTAACTCTAAGAGAATGGAAGGTTG
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA	ATGAATCACGCACAGATGATGCTTTCTTAGGCA
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATT	TTTTATTGCCGAATAATATTCTTAGGGATAGCC
GTTTCAATCCCTGATAGGGATTATTTTTAATTGCAATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096612675.1\|4656649_4659115_+\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018280.1\|WP_096612667.1\|4663592_4664504_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612684.1\|4648998_4651479_+\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018280.1\|WP_096613537.1\|4664574_4665921_-\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|224699
NZ_AP018280.1\|WP_096612682.1\|4651632_4654011_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374761
NZ_AP018280.1\|WP_096612663.1\|4667933_4668245_+\|DUF4282-domain-containing-protein	unknown	unknown	gnl\|CDD\|379475
NZ_AP018280.1\|WP_096612657.1\|4670841_4671513_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_AP018280.1\|WP_096609659.1\|4646166_4646418_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612669.1\|4662042_4663215_-\|phosphonopyruvate-decarboxylase	unknown	unknown	gnl\|CDD\|274508
NZ_AP018280.1\|WP_096612680.1\|4654069_4654750_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|250888
NZ_AP018280.1\|WP_096612686.1\|4644515_4646087_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018280.1\|WP_096612671.1\|4660889_4661969_-\|2-aminoethylphosphonate--pyruvate-transaminase	unknown	unknown	gnl\|CDD\|274512
NZ_AP018280.1\|WP_096612673.1\|4660116_4660647_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096613173.1\|4646489_4647725_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096613539.1\|4642592_4644404_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_AP018280.1\|WP_096612688.1\|4639432_4641931_+\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018280.1\|WP_096612659.1\|4669326_4670688_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379252
NZ_AP018280.1\|WP_096612665.1\|4666130_4667576_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226196
NZ_AP018280.1\|WP_096618314.1\|4654662_4656501_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|250888
NZ_AP018280.1\|WP_096612661.1\|4668437_4668923_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096612675.1\|4656649_4659115_+\|S-layer-family-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	1.0778e-25
NZ_AP018280.1\|WP_096612663.1\|4667933_4668245_+\|DUF4282-domain-containing-protein	gnl\|CDD\|379475	pfam14110, DUF4282, Domain of unknown function (DUF4282). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 93 and 155 amino acids in length. There is a single completely conserved residue E that may be functionally important.	3.04238e-13
NZ_AP018280.1\|WP_096612684.1\|4648998_4651479_+\|S-layer-family-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	3.73164e-27
NZ_AP018280.1\|WP_096613537.1\|4664574_4665921_-\|alkaline-phosphatase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	9.47094e-43
NZ_AP018280.1\|WP_096612682.1\|4651632_4654011_+\|hypothetical-protein	gnl\|CDD\|374761	pfam16734, Pilin_GH, Type IV pilin-like G and H, putative. Pilin_GH is a family from Cyanobacteria. All the proteins are putatively annotated as being general secretion pathway proteins G and H, and are likely to be pilins of the type IV secretory pathway.	3.24805e-15
NZ_AP018280.1\|WP_096612657.1\|4670841_4671513_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	1.33072e-38
NZ_AP018280.1\|WP_096612669.1\|4662042_4663215_-\|phosphonopyruvate-decarboxylase	gnl\|CDD\|274508	TIGR03297, Ppyr-DeCO2ase, phosphonopyruvate decarboxylase. This family consists of examples of phosphonopyruvate an decarboxylase enzyme that produces phosphonoacetaldehyde (Pald), the second step in the biosynthesis phosphonate-containing compounds. Since the preceding enzymate step, PEP phosphomutase (AepX, TIGR02320) favors the substrate PEP energetically, the decarboxylase is required to drive the reaction in the direction of phosphonate production. Pald is a precursor of natural products including antibiotics like bialaphos and phosphonothricin in Streptomyces species, phosphonate-modified molecules such as the polysaccharide B of Bacteroides fragilis, the phosphonolipids of Tetrahymena pyroformis, the glycosylinositolphospholipids of Trypanosoma cruzi. This gene generally occurs in prokaryotic organisms adjacent to the gene for AepX. Most often an aminotansferase (aepZ) is also present which leads to the production of the most common phosphonate compound, 2-aminoethylphosphonate (AEP).	3.7941e-154
NZ_AP018280.1\|WP_096612680.1\|4654069_4654750_+\|hypothetical-protein	gnl\|CDD\|250888	pfam01816, LRV, Leucine rich repeat variant. The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.	0.00117504
NZ_AP018280.1\|WP_096612686.1\|4644515_4646087_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	9.40436e-25
NZ_AP018280.1\|WP_096612671.1\|4660889_4661969_-\|2-aminoethylphosphonate--pyruvate-transaminase	gnl\|CDD\|274512	TIGR03301, PhnW-AepZ, 2-aminoethylphosphonate aminotransferase. This family includes a number of 2-aminoethylphosphonate aminotransferases, some of which are indicated to operate in the catabolism of 2-aminoethylphosphonate (AEP) and others which are involved in the biosynthesis of the same compound. The catabolic enzyme (PhnW) is known to use pyruvate:alanine as the transfer partner and is modeled by the equivalog-level model (TIGR02326). The PhnW family is apparently a branch of a larger tree including genes (AepZ) adjacent to others responsible for the biosynthesis of phosphonoacetaldehyde. The identity of the transfer partner is unknown for these enzymes and considering the reversed flux compared to PhnW, it may very well be different.	7.83901e-136
NZ_AP018280.1\|WP_096613539.1\|4642592_4644404_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.51011e-116
NZ_AP018280.1\|WP_096612688.1\|4639432_4641931_+\|S-layer-family-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	6.271e-26
NZ_AP018280.1\|WP_096612665.1\|4666130_4667576_+\|hypothetical-protein	gnl\|CDD\|226196	COG3670, COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	4.27294e-178
NZ_AP018280.1\|WP_096618314.1\|4654662_4656501_+\|hypothetical-protein	gnl\|CDD\|250888	pfam01816, LRV, Leucine rich repeat variant. The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.	0.00784182
NZ_AP018280.1\|WP_096612659.1\|4669326_4670688_+\|hypothetical-protein	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	5.9882e-43

>NZ_AP018280.1|WP_096612675.1|4656649_4659115_+|S-layer-family-protein
MRVTFTLLGLIGGMLVCAICNNYVKAQVIPDGTLKTTVSQSGNNFTITNGDRIGNNLFHSFSQFSVPSQGSAFFNNASDIQNIFSRVTGGSVSNIDGLIKANGSTNLFLLNPSGIIFGADAKLNIGGSFVGTTAESIKFADGNEFSAINPQTQSLLSMNVPIGLQMGSNPGAIAVQGLGHNARLSDSFQVSGLNIETRGLQVQPGKTLALVGRNVTLDGALLSAPGGLIELGSIASGNVVLNSVPQGFAFSYPNTSSFSNIQIRRRALASTRNLNGGNGGAIQIQGKQISIQDGSLVLVQNRSNQTAGDIRISATESLDIIGKSPDFQSSSSLVNETISSGAAGNIIINTPQLNIDRGGYIFNRTFSAAPGGNILVNSDNVRVNGFASGDPSAFRAISQILASSYGNGKGGNIFVSTQNLSVSAGGNIAARPYASGNGGDVNVKADTIEVSSRGTPNGSYFSLISTATFGAGNAGNLAINTRKLSVQAGGRVSASSIVLGNAGSLNINASESIDVSGIKDAANPSYIGTAVRPVGLFAQISRANAGNTTINAPTLNITDGATVFVQNTGSGTAGVLQINANTLKLDNEASISASTTAGEGGNINLQLRDLLLMRHSSFINAEAGGSGNGGNITINAPNIVGLENSDIIANAVQGKGGNIQIATQGIIGLQYRDLLNPRELLTNDITASSQFNLSGTVKINNIGVDPNSGLVELPANLTDPSQKIATSCADNSGSSFIATGRGGIPQNPSQELRSDRTWSDIRDISAFRKNNSVIGEIPTTPETLVQATSWHRNVQGKIELVADKPSTQMQQQLTCAAVSKS
>NZ_AP018280.1|WP_096618314.1|4654662_4656501_+|hypothetical-protein
MQLRKTSEYVRETIAKCTDSPPEKLRELLTLKIKITTIVEVAKNPKTPIDCLIELANHNSRIVREAAMRNPSLPRSIVNNFFQERFLATNPHTEVEKLRELCVSKWSFIRARVAKHPNLELSDLKKLARSPELKIRVAVASHPRADVRILKHLTGDRSILVRRAVALNSQTPQECLEILSRDRNVYVRANVAKNPCTPLEILLLLSQDKDSRIVKNIAFNPAIPQELRSQLQLEIPQREPEHIYLWRRLFSGPYEYNGIPIKELWSQEQYDLAASAITPIPQLLELIKITPNDIYWEAVHNICQQVICNPDISSELLLEILDIRSIDIYAAVASHPHISDAVCNRIVNNEFRDYRLSLLMLQNSNISLDFIEKLLSHRKSEVRQFALKKHQQIFADNDIKNIFLTQYNAATCEQTPLEKLTQLSKHKSVLIREAVAKNPRIIKAYSFCTKIRTCLERLAKDKNQSVRIAVANNINTPIHILEILAKSYQYEPGVHTRYQRHHNRKEHKVFVIAVKKLMQIAPEIASKYLVQYIEPNCHTLDSIPFRLAILQNFPVPIEYLAKKIKTLHLFPWYERYLIVQNPQASTEILQMFLKDVNRVVRAAAKARLTETQ
>NZ_AP018280.1|WP_096612680.1|4654069_4654750_+|hypothetical-protein
MVELMQVSNQVAITAANSIHTAPELLTELAGHEDIQVRQAVAGNPNTPTDVLLQLAEEFPQEFVKNPVLPLLQLENPEFHKLIPYSVIQNILACEGAPQEWLRLFATYVCYDYLLAIVHNPQASKQVLQLVAENEYCGAVIHELIELHVNIAGEMKSGWQEYADNKLQYIQDILKSEYYHPRDKGQYYKFTFWELGLSCNFVKLQNMYERLSLNVPTLHQKNYGNY
>NZ_AP018280.1|WP_096612682.1|4651632_4654011_+|hypothetical-protein
MKLPLFSLFPSLSLVLCLTLMPNVRANAIANQQNQQISVQEIATRKEIRTLLGSVGRAQQAHFLENHRFATQIKQLGLGDDIQNSIPGYQWQVFTDKKAEIAAITVLSPKQSGSRTYVNFVNLAISSAGEKITITTLCESKQNQRIIPKVPTKILKNQDTMKCPSGFRKFELSQDEEKIYEQVKKEKELVSVVGIFNSLQKQYYSQNQVFADRNEELLGFDINKIQPQLKSSFKLLPIQDTKQGIITIATFPNQNYKSYLGIVKTTEKTSGKVESLICEVPQQESIDLQKLKKLSLNILLNCPPGSKEVSLSSEEIAYVNEGKEKLQNYKAEIAEIKQPKKTPFLKAADKLAQEGKYLEALEKYYLASGALGINEYDILLEFSGESTFNPTRDALFKKIELVLQAAKPLIEQQKKEIQSEMYSVFDRFPNEKNHTGQKIKEIAASQLGFNILTTPQQELKIPANKSEEFSEIAESLREYFNDKSKKPNQKLSDNLRKYTNKNRRAIATIRDLLLNGEIPRWGTDYKWVKEGDFAASAPSYLNIVNLQRLLAIDILDQQQQGNNPEMLKSLEASWRLSESLQNDPSLLGQLVNIIIRRSQIQVMEKLDNLPVVWQQRLLAYDYTKSMIQALKVEAFSQLQGLDKIITPEKDTAIAKLYRNWYGVNTYKLNQAFYAEVERQQNNLCSVDIKALEKQYFNSESSISPSYVNQILKAQHLMLESEMMQKVLQIKAEIAQGKTVPNYLLNIPSSICSTNKWVYKSFPNAKWSISLDKQPTWQSRIARSPLTYTGDRP
>NZ_AP018280.1|WP_096612684.1|4648998_4651479_+|S-layer-family-protein
MGNISVWFGLIGGIITGAIWSNSVNAQVVSDGTLKTTVSQSGNNFTITNGDRIGNNLFHSFSQFSIPTNGSALFNNTADVQNIFSRVTGGSVSNIDGLIQANGSANLFLLNPSGIIFGQNATLNIGGSFVGTTANSIKFADGVEFSATNPGATPLLTMSVPIGLQMGSNPTPITVQGTGHALTAVSTVAPITQNPSSSELRVKPGKTLALVGGSLNLTGATLNAPEGRLELGSLDGVGLVSLNPISQGYQLGYESGQSFADIQLTQKSFLSIGALPTVGALNAGSVQLQGKHIQISDGSIIFSKNLGNVAGGEFFLQASEGIDIVGTTANAQIRSGIRSEGLNTGAGSPIRIITPHLTISQGAGVNTNAFGLAASGDILIDAGTVELSGFSPINPTGVTSLTTSSRTAKSAGNLSINSNNLLVSQGAAISSVALASGSTGQVTIRSKNTTVTGDNPAGLYSNISAITYGTGDAQTLTLDTNRLQLLNGGVVSTTSFLIGKAGNLNINATESILIDGHSQANNSSINSAVLIPPSLLQKLFNLPNILSANAGTVNVSTPNLTLKNGGVVSVTNQGTGDGGNIKIAVSKMFLDNQGSIQAQTTSGEGGNITSQVSELLLLRHNSLISATSAGTGNGGNININAPVIAGLENSDIVANAVKGRGGNIDITTQGIIGLEFRNTLTPRVDLTNDITASSEFNVNGTVQVNTIGVDPNSGLVELPANITDPSQQIATGCADSSGSSFIATGRGGIPQNPNQDVKSDRTWSDVRDISAFRQTQPVQAKIPTTPETLVQATSWHRNAQGKIELVADKPSTPVQQQLTCAAVPKS
>NZ_AP018280.1|WP_096613173.1|4646489_4647725_+|hypothetical-protein
MECGISFRGVEKVFELFNNYEEQATPSFSCVRKWLARIGIYELTKEKEYRDDWIFIVDLTLELGKQKALVILGVSQQHIEENVMKQKRGLAHEDVKIFGLEIMDSTKGEIIESKLEKISQKVGVPVQIVADNGSDLARGIKLYQQNHPDIIYTHDVTHAMALLLKYQLDSDERYQSFIQKCNISRQKLQQTDLSFLSPPTQRSQCRFFNVERLTNWGIKLLNSSPDTLIKLMPDSDPSLITQKIVDKLGWLVDYESDLIQWNQMVSLTRGVETQLKQSGISHKTLDFFEQNKVIFDDNSLQKLQQSILGYLSVQCRKIKNQSTFLATSDVIESLFGKYKQFSARCPFKEMGQMLLTICLSTMNLTTALIKNALETISFSDVEAWLSEVFGQSTLSKRKTLFSGDCDDIKSA
>NZ_AP018280.1|WP_096609659.1|4646166_4646418_+|hypothetical-protein
MQEFKSPVSRLARLFQKGRDNWKEKALLKQKKIRALEIKVRDLLDSREEWKNRALMAESKLKELNIEGDLDEKKRKFKSKQKS
>NZ_AP018280.1|WP_096612686.1|4644515_4646087_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MKAVPFLLIVTTGLLIPGIMRSATAQVVSDGTTNTTVNSSGNNFTILNGIDKGNNLFHSFSNFSVPTNGAARFDLVNTPNITTIFSRVTGGNISNIDGLIQTLNANNNAVSLFLMNPNGIVFGENAKLDISGSFVGTTANSIKFADGVEFSAVNSSEPPLLTMSVPVGLQMGINAGAIQVQGTPANNPQFRTPTLSMKANQTLALIGGQIDVNSANISAPDSHVELWAMQNGTVNIPTFGNWQLASSSLSPTWGTITLQQSSSIDTSGANGGAINIRGQGLTLQEGSNIGSATGTNGQGEGITVQTTEFVNLLGASHPSNVVFPGLNTSVRGGMATAGNITVETPRLQIDNGGWLSSVNMVTNFSALSSQPIRNSKTGNIMVRATEIDIRGYTPFINPATRAVVSSAITTLTGGTQNESGAITVEAERIRLQDGGRISTDLFGLLAPASGRAGNIFVTASQSLDILGASPANATSAIISSINILANGQGGNVTVNTGQLRLAKGGTISSQITGNPNVAIAGRG
>NZ_AP018280.1|WP_096613539.1|4642592_4644404_+|group-II-intron-reverse-transcriptase/maturase
MSNTSFKTTGEWRSINWRKLERRVYKLQKRIYRASQRGDVKAYRRLQKTLMNSWSARALAVRRVTQDNKGKKTAGVDGVKSLTPKQRLALIDKLKLGSKVNPTRRVWIPKPGKDEKRPLGIPTMKDRALQALTLQALEPEWEARFEPNSYGFRAGRSCHDAIEAIFNCIRYKPKFVLDADIASCFDRIDHSALLKKLSTSPTIRRQIRAWLKAGVIDGKQLFPTSEGTPQGGTNSPLLANIALHGMENRIKQAFPKGTILKKGKYSGYQPGAMLIRYADDLVILHEDITVVQKCREIMEEWLKDYGLELKPSKTRLIHTLSTYEGQKPGFDFLGFNIRQFSKGKHHTGKNTKGEKLGFKTIITPSQEKVKAHYDHLARVIDAHKAAPQAALIKQLNPIIRGWANYFATVISKEIYAFLDNLVYLKLVSWAKFRHPKKSCFWVSKKYWHSIDGDNWVFATKEAGENQVRLLDHTRIKIARHIKVIGVASPYDGNLIYWSTRMGNNPEMPKRVASLLKWQKGKCAHCGLFFRENDVMEIDHIIPKSQGGKDEYKNWQLLHRHCHDTKTAEDSSPGTQSGCNSTKPKPPSELNWFWEEDMLVMRYT
>NZ_AP018280.1|WP_096612688.1|4639432_4641931_+|S-layer-family-protein
MKTITFLLILTTGLLTPGIMRSAMAQIASDGTTNTIVNPSGNNFTILNGIEKGNNLFHSFSNFSVPTSGAAIFDLTNTPNITTIFSRVTGGNISNIDGLIQTLNANNSVSLFLMNPNGIMFGQNAKLDIGGSFVGTTANSIKFSDGTEFSAVDSNTTPLLTMNVPVGLQMGSNPGAITVENTGHLITIGFFAPADRSNNPIGLQVGAGNTLALIGGAVNFSSGIVTTNGGGHLEVGSVSAGQVKLNSTSTGLVGDYSAVKQFNDINLAQQSLLDASGSGGSIQLQGRNISFAEGSGALLQNFGTQQSSQGITINATGSINLSGNTSYGKLGSLIQIDNLGITQTGDINLSAAQLSLKDGAHIHNWTFTPIPGGNITANVAGAIAIEGFAPTNPLVSTSITSITLNSGKAGDITISSDNLRILNSGSISTISTGSGQAGILRFNVADLVEIAGNNPFTALSSSVISSASNTGDSGSTFINTSRLVIRDSGILGSSTVASGAAGSVTVNASESVDVRGKGSGSILPARIASSAEILDPVTQAILGLLAIPTGNAGSLSIDTPLLRVTDGGFVTVKNDGPGKAGDLQINANSIFLNNQGSITASTASGDGGNIRLKLQDYLLMRQESLISATANGDGDGGNLSINVPIAVGLENSDIIANAVEGRGGNINITTQGIIGLAFRNTLTPRIDQTNDITASSQFNVNGDVQINNFGVNPNSGLVELPGNVTDPSQKIATGCADTSGSSFIATGRGGIPQNPSQEVRSDRTWSDIRDISAFRQNQPVQAKISTTPEVPTETFTQATSWHRNAQGKIELVADKVSTNMQKALTCAAVPKS
>NZ_AP018280.1|WP_096612673.1|4660116_4660647_+|hypothetical-protein
MKKIIPLDNFTILTPDTTDVVQQNLKQCLFYRGSISEQGFKITRNLYRSVFTLIKGRFEAQSHQTAVHIQISLHPFLIAPLGLFFLFWYGIAVPGMFESAKYIYAKPPRVTIPDDGNVAQSAIAAISSAPEGTMPTHLAAIYLGLPIVLLIVFVVSFWVDAKQIRRELTQIIRGKI
>NZ_AP018280.1|WP_096612671.1|4660889_4661969_-|2-aminoethylphosphonate--pyruvate-transaminase
MILLNPGPVTLSDRVRNALLQPDLCHREVEFSQLQTKIREKLLQIYGLQARHWVTVLLTGSGTAAVEAMLTSLVPRSGRLLVVENGVYGERMAKIAQIHRLDYSIVHHPWGEAIDFQLLTEFLDSHLDITHLAVVHHETTTGRLNNLKELARICRDRHIKILVDAVSSFGAEEIDFAAWGITACAATANKCLHGVPGTAFVILKRNALPPIEIVPRTLYLDLGTYCRQQDAGGTPFTQSPQIFYALAEALEELEETGGWRARKAHYTQLANLVREGLTAIGIEPILPQEDSSIVLNAYKLPKNFTYEEFHDRLKSAGYIIYAGQGNLSKSIFRVSTMGAICQADMERFLEVIKKMLNRY
>NZ_AP018280.1|WP_096612669.1|4662042_4663215_-|phosphonopyruvate-decarboxylase
MIQAEQFVEAARKLGFEWYTGVPCSFLTPFINYVINDTQLTYISSANEGDALATAAGVVIGGKRAVVMMQNSGLGNAVSPLTSLTYIFKIPVLIICTLRGDVNLKDEPQHELMGQITDKLLETMGIPWEYFPDKASEIAAVLQRAHNYMQQEHRPYALIMRKGTVAPHALQTKEGVGGWGEGGMGRGGEVGLSQSVNSLNTRHQALEAIVQQTNPEDTVIIATTGYTGRELFALSDRPNHLYVVGSMGCASSLALGLSLARPDLTVVVIDGDGAALMRMGNFATIGAYAGANFIHILLDNEVHDSTGAQATVSRGVSFAKIAEACSYGTTLMGSELGLIEALFMEKTQNRPKFAHLKIRPGTLENLPRPNMSPAAVLQRLMNHIHRKREK
>NZ_AP018280.1|WP_096612667.1|4663592_4664504_+|hypothetical-protein
MKASAKFDFEDERFNAPPSQVIPWCQMINPRYNDDGVQSHGLAIKLDNAQAVGFEPDDNWQEVEHEFSSGVEKVYLSTTPKIVIVRRGPLSVKDRETGTKLGTLRDNYDAFLADKLKFKTFTRYLIFLVGENKKFLHESPLQLTLHGAAGASFSKTYCEYQQGRASGGFVVELERAYASFRKQPFMPKGALFHAHGIFCPIIESEERGIHPNTVLVASTVDYKHPTVSTLTQYLIASDSPESALITRAFEDYKEFGKEQVRTEANGNSGNNANNGNYNKMAIAGVASSSYVYADDDDFAYPPY
>NZ_AP018280.1|WP_096613537.1|4664574_4665921_-|alkaline-phosphatase
MRHLCQFISLAALSLVVITSCGEAYSNASNSQQGNVIFIHPDGTSPSHWGAARMLHYGPDGRLNWDKMSHMGVYLGHMKNQLTATSNGGAVTHATGVKVNADSFGLDEKLQPVVAASGKTQTIIQEAIASGKGTAIINSGMIHEPGTAAFVAKEPNRRQFAEITKQIVESNVDVILGGGEMWYLPKGTAGKHSTAQQSQRTDGVNLIEVAKKKGYTVVYTRQELLKLPANTKKVLGVFAADDTYNDATEEDLKKDNLPLYVPTAPTVAEMLDVTLKILSAKNKNFIVVLEEEGTDNFANYNNAPGTIEAMKRADDAVGIAMKYIENNPNTLLLTAADSDAGGLEVIGVTEKDFPLNKPIPAKSNNGAPWDGKEGTSTPPFVSAANQEGKSFPFAIGWSSGGDNVGAIVSKAQGLNADKLPSTLDNTDIYRLMYRTLFGKEIAPYRKEK
>NZ_AP018280.1|WP_096612665.1|4666130_4667576_+|hypothetical-protein
MTTASNPISSQNAWAKPILETAKEFPHTPITTKEGKIPSGLRGTLYRNAPGRLERSGIRMGHWFDGDGAILAVNFADNGASATLRYVQTKGYQEEAAANQLIYGNYGTVAPGSIFNKLFKGTKNSANTSVLALPDKLLALWEGGKPHALNLQTLETLGEDDLGMLTNGLAYSAHYKQDTQTGEIFNFGISPGLNATLHIYKSTASGDIIQKAVHQLDGISLTHDFVLAGQYLIFFLPPLRLNLLSVITGKSCYSDAFRWQPSKGTQFLVIDRETLKLVSRGETEPWFQWHFCNGYVDTSGTVIIDIARYEDFHTNQFLKEVATGKTHTIAKSHLSRVYLNPQTGKVLKIEKIFDNHCEFPSVPPENVGKESRHAYLSTFRNPAEMKGELLNAIAHYDYSKDVLTIANLGSNHYPSEPIYVQDKENPLQAWILTVVYNGTEDGSEVWIYDAQKLNEEPICKLKLPDVVPHSFHGTWKQSLTK
>NZ_AP018280.1|WP_096612663.1|4667933_4668245_+|DUF4282-domain-containing-protein
MASNKNFFSQLFDFSFSEFLALKIVGVLYGIGMFFAGIFTLGIAVNSFRVGFASGVVGLILAPIIFLLYILFIRIALEGMIVAFRTAENTARIAENTKHLRNP
>NZ_AP018280.1|WP_096612661.1|4668437_4668923_-|hypothetical-protein
MIHHISIAARQPQHVAQVLAEVLKANVTPFPPHPGSYLVIPFDEQGTAIEVYPLGSEILPGDADEQCHFRINDRASEFTATHAAISVPVSREEIEEIGKREGWRVVYCDRESFFDVIEFWVENRLMIEFLTPQMTSKYLKFATNRENVQLFMAAPALSISN
>NZ_AP018280.1|WP_096612659.1|4669326_4670688_+|hypothetical-protein
MPDILALLECLQRYTTRTTLRRWSRIISAMLAMSGRITMLGISRWCGKGGSYRTIQRFFAHSLPWAGLFWVFFREHIFCQKETYLLAGDEVVVSKAGKKSYGVDKFYSSLHDKPIQGLSFFALSLVSIEQRKAFPIRIEQVIKPKVEKQAKLTEETKKPKEKPNQEVPKKKGGRPKGSKNKDKTEVVFTSELLRIRILIQDLLKKLSKFLPLTYLVLDGHFGNNNAVVMTRQMGLQLISKMRYDSALYIPYENPDPSRKCRRKYGDRIDYSFIPDKFLKKTETVENIRTDFYQTQLLHKEFSQTLNVVIIVRTNIVTSHRTHAVLFSTELSLSYVHVIDYYSLRFQIEFNFRDAKQFFGLEDFMNVGKNAVTNAANLAFFMVNISQVLLSHFRKFNPDFSITDLKAIFRGYKYVEETIKLLPEKPDPVLLANIFHRVTNLGRIHPADPCSSSS
>NZ_AP018280.1|WP_096612657.1|4670841_4671513_-|rhomboid-family-intramembrane-serine-protease
MFPLYDENPTRITPYLTYGLIGMNVLIFFHELSLGRQIEPFFQTYAVIPAELKNNFAGEWTTLFTSQFLHGGWWHLLSNMLYLWVFGNNIEDRMGHFKYLIFYLSCGALAALCQCFIDFNSIVPSLGASGAISGILGAYLIRFPQAQVMTLAFLFFFVTTFRVPAMLLIGLFVVQNVVSGLASLQAAANMSVESGGVAYWAHIGGFVFGIILGPMFGLFRRDD

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Crispr_ID: NZ_AP018280_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_9

4719463-4719565

Orphan

Consensus_repeat	Method
AATCGATTAAATGTCGATCGCTCTACCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_9

>merge|NZ_AP018280|9|4719463-4719565|CRISPRCasFinder
AATCGATTAAATGTCGATCGCTCTACCAAATGAGCTAACTTTTTGGTGTACGATGCAAGAGTTGAACTTGCGCCCAATCGATTAATGTCGATCGCTCTACCAA

>NZ_AP018280|9|9|4719463-4719565|CRISPRCasFinder
AATCGATTAAATGTCGATCGCTCTACCAA	ATGAGCTAACTTTTTGGTGTACGATGCAAGAGTTGAACTTGCGCC
CAATCGATTAATGTCGATCGCTCTACCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096612613.1\|4700517_4705650_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018280.1\|WP_096612611.1\|4705805_4706030_+\|KTSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|379296
NZ_AP018280.1\|WP_096612605.1\|4710314_4711397_-\|photosystem-II-q(b)-protein	unknown	unknown	gnl\|CDD\|130221
NZ_AP018280.1\|WP_096612591.1\|4722474_4723098_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018280.1\|WP_096612607.1\|4707893_4708376_+\|DUF4440-domain-containing-protein	unknown	unknown	gnl\|CDD\|227212
NZ_AP018280.1\|WP_096610164.1\|4721346_4722489_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP018280.1\|WP_096612609.1\|4706119_4707526_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_AP018280.1\|WP_096613531.1\|4708545_4709766_+\|geranylgeranyl-reductase	unknown	unknown	gnl\|CDD\|177713
NZ_AP018280.1\|WP_096612583.1\|4725562_4725799_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612587.1\|4723895_4724726_-\|DUF4351-domain-containing-protein	unknown	unknown	gnl\|CDD\|227751
NZ_AP018280.1\|WP_096612601.1\|4714049_4714991_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_AP018280.1\|WP_096612589.1\|4723209_4723869_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|235662
NZ_AP018280.1\|WP_096612585.1\|4724807_4725446_+\|thiamine-biosynthesis-protein-ThiF	unknown	unknown	gnl\|CDD\|366360
NZ_AP018280.1\|WP_096612603.1\|4711750_4712137_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238779
NZ_AP018280.1\|WP_096612579.1\|4726555_4727917_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|206646
NZ_AP018280.1\|WP_096612597.1\|4717352_4718879_-\|membrane-protease-subunit,-stomatin/prohibitin	unknown	unknown	gnl\|CDD\|259816
NZ_AP018280.1\|WP_096612595.1\|4719895_4720480_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612593.1\|4720585_4721254_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018280.1\|WP_096612581.1\|4725872_4726103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612599.1\|4715583_4717317_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223510

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096612613.1\|4700517_4705650_+\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	3.10542e-90
NZ_AP018280.1\|WP_096612611.1\|4705805_4706030_+\|KTSC-domain-containing-protein	gnl\|CDD\|379296	pfam13619, KTSC, KTSC domain. This short domain is named after Lysine tRNA synthetase C-terminal domain. It is found at the C-terminus of some Lysyl tRNA synthetases as well as a single domain in bacterial proteins. The domain is about 60 amino acids in length and contains a reasonably conserved YXY motif in the centre of the sequence. The function of this domain is unknown but it could be an RNA binding domain.	3.19732e-19
NZ_AP018280.1\|WP_096612605.1\|4710314_4711397_-\|photosystem-II-q(b)-protein	gnl\|CDD\|130221	TIGR01151, Photosystem_QB_protein, photosystem II, DI subunit (also called Q(B)). This model describes the Photosystem II, DI subunit (also called Q(B)) in bacterial and its equivalents in chloroplast of algae and higher plants. Photosystem II is many ways functionally equivalent to bacterial reaction center. At the core of Photosystem II are several light harvesting cofactors including plastoquinones, pheophytins, phyloquinones etc. These cofactors are intimately associated with the polypeptides, which principally including subunits DI, DII, Cyt.b, Cyt.f and iron-sulphur protein. Together they participate in the electron transfer reactions that lead to the net production of the reducting equivalents in the form of NADPH, which are used for reduction of CO2 to carbohydrates(C6H1206). Phosystem II operates during oxygenic photosynthesis and principal electron donor is H2O. Although no structural data is presently available, a huge body of literature exits that describes function using a variety of biochemical and biophysical techniques. [Energy metabolism, Electron transport, Energy metabolism, Photosynthesis].	0
NZ_AP018280.1\|WP_096612591.1\|4722474_4723098_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.96313e-21
NZ_AP018280.1\|WP_096612607.1\|4707893_4708376_+\|DUF4440-domain-containing-protein	gnl\|CDD\|227212	COG4875, COG4875, Uncharacterized protein conserved in bacteria with a cystatin-like fold [Function unknown].	9.84374e-51
NZ_AP018280.1\|WP_096610164.1\|4721346_4722489_+\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	8.20706e-07
NZ_AP018280.1\|WP_096612609.1\|4706119_4707526_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_AP018280.1\|WP_096613531.1\|4708545_4709766_+\|geranylgeranyl-reductase	gnl\|CDD\|177713	PLN00093, PLN00093, geranylgeranyl diphosphate reductase; Provisional.	0
NZ_AP018280.1\|WP_096612587.1\|4723895_4724726_-\|DUF4351-domain-containing-protein	gnl\|CDD\|227751	COG5464, COG5464, Uncharacterized conserved protein [Function unknown].	2.49038e-34
NZ_AP018280.1\|WP_096612601.1\|4714049_4714991_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.67872e-16
NZ_AP018280.1\|WP_096612589.1\|4723209_4723869_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|235662	PRK05986, PRK05986, cob(I)yrinic acid a,c-diamide adenosyltransferase.	2.95565e-104
NZ_AP018280.1\|WP_096612585.1\|4724807_4725446_+\|thiamine-biosynthesis-protein-ThiF	gnl\|CDD\|366360	pfam00899, ThiF, ThiF family. This domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1.	1.33211e-28
NZ_AP018280.1\|WP_096612603.1\|4711750_4712137_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238779	cd01521, RHOD_PspE2, Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins.	7.19766e-59
NZ_AP018280.1\|WP_096612579.1\|4726555_4727917_-\|hypothetical-protein	gnl\|CDD\|206646	cd00880, Era_like, E. coli Ras-like protein (Era)-like GTPase. The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.	4.39198e-13
NZ_AP018280.1\|WP_096612597.1\|4717352_4718879_-\|membrane-protease-subunit,-stomatin/prohibitin	gnl\|CDD\|259816	cd13438, SPFH_eoslipins_u2, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial SLPs remain uncharacterized.	1.2682e-102
NZ_AP018280.1\|WP_096612593.1\|4720585_4721254_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	5.48408e-33
NZ_AP018280.1\|WP_096612599.1\|4715583_4717317_+\|ATP-binding-protein	gnl\|CDD\|223510	COG0433, COG0433, HerA helicase [Replication, recombination, and repair].	4.35896e-52

>NZ_AP018280.1|WP_096612597.1|4717352_4718879_-|membrane-protease-subunit,-stomatin/prohibitin
MWKSFYIKPNEIGILYNRSDFKKILQPGTYTYFGRNWQVKTYDLNEPEANIENLELLLRNHGSELQEHVVIVRTTFRQAALVRLGQNWVSVKPNQLRAFWRGFIEVETHIFDLEENLELPGNFVQQIRGISLFGLNKFQISEAEIGLLYVQNNFVRPLQPGEYAFWNLDKTIAVNKISRIIPNPDFPLPEVLIERHPDFVAAYCEIVQLQNNQVAIVRYQGKVIAILAPCDRKLFWQGVEVEVIDIGVDAKLPQHLVAELISGVPATYTLSHNSLHVCEVPPQHIGLLYINQEFQTQLQPGLHAWWIFGRSLQTPVFDLRQQNLEISGQDILSKDKVPLRLNLTAGYRIVDPLQAKNTLVDISGYLYKELQFALRGAVGEKTLDALLEDKGAVDISISEYIRQKTSAYGIEVDSVGVKDIILPGEIKTILSKVVEAEKAAQANVVRRREETAATRSMLNTARVMEDNPVALRLKELEVLERIAEKIEKIQVNGSLDSILTDLIRMNRE
>NZ_AP018280.1|WP_096612599.1|4715583_4717317_+|ATP-binding-protein
MQLGQPLGSVTQGSLTGGLEVRLHPDISVEDMRVGKFLVVQGMRSRFFCMLTDVALGMANQRIIANPPNWEDTFLRDVLAGSGTFGTINLAPMLMFTPEVEEDFPSKNGKSANALVRAATKGLASFQPQTSTTMELLPVKTIPSHFSQVYEASEEDFRRVFGWEDDIHRKNFSIGKPLDMDVPVCIDLDRFVERSNGVFGKSGTGKSFLTRLLLAGIVRKNAGVNLIFDMHSEYGWQAVCEGKTYSTVKGLKQLFPDRVEVYTLDPASTKRRGVQNAQELYLSYDQIEVEDIRLCSRDLGLSEASLDNANILSAEFGKAWILQLINMTNEEIKMFCEEKRGHQGSITALQRKLLRLENLKYMRSACPQNYVNQILKTLEAGKNIVIEFGSQSDMLSYMLVTNMITRRIHQHYVGKAEQFLQSGNVVDKPNQLVITIEEAHRFLDPAIVASTIFGTIAREMRKYFVTLLVVDQRPSGIDNEVMSQIGTRVTALLNDEKDIEAIFTGVSGGTALRSVLAKLDSKQQALILGHAVPMPVVVRTRPYDEKFYAEIGDQIWEEKADDEVFAAAELAKADLGF
>NZ_AP018280.1|WP_096612601.1|4714049_4714991_+|glycosyltransferase-family-2-protein
MSRLLTIAIPTFNRAELLDKQLEWLSQAILGFENDCEILISDNCSTDNTQDIIKKWQNKLSNIIFISNRNTSNIGVMRNIMFCLNTAQSKYVWTIGDDDPIKNNTLSYIIDNLKKHPELSLLVLNYSRFNAISSQIIKERNFNITEEKIHDDARTFIEHNIKEGIFGFGFMTAQVYRTDTVKMALKKWQNSLNNLEMQVFWGAYCALQGSIKFSHDVFVEYTCGTNCLSDKKTWFKVYYADLVRVYTKLKEIGYSPEFCQKLIIRHFTHQHTLRILLGAIRRYPILGLKTAIPYLFVVLSNTFQLMLTRRQFS
>NZ_AP018280.1|WP_096612603.1|4711750_4712137_-|rhodanese-like-domain-containing-protein
MDEQIKHYQSKLEFETDSWDLKVALESGENILVIDARSSDAYQQEHIPGAINIPHRTMSEETTNHLDRTALVVTYCDGIGCNASTKGAMKMAKLGFRVKELIGGLDWWKRDGYKTNSSDATKSNACGC
>NZ_AP018280.1|WP_096612605.1|4710314_4711397_-|photosystem-II-q(b)-protein
MTATLQRRESANVWEKFCSWIASTDNRLYIGWFGVLMIPTLLAATTCFIIAFIAAPPVDIDGIREPVAGSLMYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVVFHFLIGVFCYMGREWELSYRLGMRPWICVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHQLGVAGVFGGSLFSAMHGSLVTSSLVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTSLGISTMAFNLNGFNFNQSVIDTQGRVINTWADVINRANLGMEVMHERNAHNFPLDLAAGDAAPVALTAPAING
>NZ_AP018280.1|WP_096613531.1|4708545_4709766_+|geranylgeranyl-reductase
MTLRVAVVGSGPAGSSAAEVLAKAGIETYLFERKLDNAKPCGGAIPLCMVSEFDLPADIIDRRVRKMKMISPSNREVDINLINQEEYIGMCRREVLDSFLRNRAAKLGATLINATVHKLDIPSNNTDPYTIHYVDHTEGGAQGIAKTLKVDAIIGADGANSRIAKEIDAGDYNYAIAFQERIRIPEDKMAYYNDLAEMYVGDDVSTDFYAWVFPKYDHVAVGTGTMHVNKASIKQLQAGIRARAAEKLEGGQIIKVEAHPIPEHPRPRRVVGRVALVGDAAGYVTKSSGEGIYFAAKSGRMCAETIVEFSNAGAKIPTENDLKVYLKRWDKKYGLTYKVLDILQNVFYRSDATREAFVEMCGDLDVQKLTFDSYLYKTVVPANPITQLKITAKTIASLLRGNALAP
>NZ_AP018280.1|WP_096612607.1|4707893_4708376_+|DUF4440-domain-containing-protein
MKKILFFSTWLSLTLALNLAIASTSPNQKITNCIHVTEDDVKTLFDRWNNSLRTRNPDIVVSNYAKNAILLPTVSNHWRTNSTEIREYFVKFIKNNPVGKIDNRIIKLSCNSVIDTGFYTFTFTTQGQKKTVLARYSFVYEYLNGKWLIVSHHSSKMPES
>NZ_AP018280.1|WP_096612609.1|4706119_4707526_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MSQQFATTGTIAAIATAIAPQQGSVGIVRLSGTEAVFIAQKLFYAPGKQVWESHRILYGYIRHPQTQQTIDEALLLIMESPRSYTREDVVEFHCHGGIMAVQQVLQLCIENGARLAQPGEFTLRAFLNGRLDLTQAESIADLVGAKSSQAAQTALAGLQGKLAQPIRQLRNQCLDILAEIEARIDFEDDLPPLDCNYIIQEFVKISGEINRILVTADTGELLRTGLKVAIVGRPNVGKSSLLNAWSRTDRAIVTDLPGTTRDVVESQLVVGGIPVQVLDTAGIRETEDTVEKIGVERSRKAAQAADLVILTLDASQGWTSEDQEIYEQVKHRPLILVINKIDLIDLLSPENIEAQYFIYPQEINKLVKTAAAKNQGIEDLEAAILETVKIKKVTAANIDFAINQRQAAALLQAKTSLAQVQKTIEQDLPFDFWTIDLRTAIHALGEITGEEVTESVLERIFSKFCIGK
>NZ_AP018280.1|WP_096612611.1|4705805_4706030_+|KTSC-domain-containing-protein
MELQQVESSMVRAVGYDETSETLEVVFSSGKIYKYFPVPKKIYDQLLAAESKGSYMQDAVIDCYQYRQIRKRSR
>NZ_AP018280.1|WP_096612613.1|4700517_4705650_+|hypothetical-protein
MVGKHPAAEGILAANDRALNSLRRAIAFSQGQFSLCLVGCNYGVLRKQMLQRLEEVLGEEYPIHKVTLSSNVISLYSTIHAELANKQPAALVILGLESVEELDDLLRTINHIRDEFRKRHPFPMVFWVNDELLRKLRRFAPDFTSWAATPIRFEMTTQELRQFLQDKTDTLFAQILDIGNVSDSKESPHKTLGEVWDYSSYEFRCAIQELQHRGIDLEPELDASLAFVSGLDDYANDKIDLAIEFFQQSLEFWQQEKTEKSAFSPSLPFTSSIPPNPPPPHLLRQGALLFYIGLCYFRLAERSHIEHRQRWQQAKSYFQQCLDVFEKAQRPDLMAQIIGLLAEVLQHLKEWDELQVVADKSEKLHHAFGTNCQLAYDFGFLAKVAVARENWGQASQLARVALWQLHEAKENSYSPPNLFPLLMGQVYRLTLAQALQNLSDGGSNPLPEYHKIAGEQLELASQELNAALVGSDFNYDVYRYIRLLRWLRSLYFESGLYLEAFIIRQKRRSVEQQYGLRAFIGAGRLQPQRHPKTPALSSPTSSGSVALEITASGRQRDIHNLIARVSRADHKLTIIHGPSGVGKSSTVTAGLVPALQQRAIGDQIAVPVVLQVYTDWVRELGKALGNAIVATKPVVMRKAALDTLPPYPATPITIDGVLELLQENARNSIITVLIFDQIEEFFSGCSLIQLQEFDHFLCVALNVAFVKVILSVREDYLHRLLEFKQLSGLEAINENLLDKNIRYQLNNFSREDAKTVIQGLTERSQYHLEPALVDALVEDLSAELGEVRPIELQVVGAQLQDERILSLSKYEQFRPNKLIERYLKELIRDCGPENERAALLVLYLLTDETKKRPFKTRAELAAELAELENVEKLELVLEILVRSGLVVLFPEVPERYQLIHDYLVDLIRILQQDELSLQEQVKKLRQQVQQSELEISRLNSELRHKKQAKLQDNYPQTGSDLLGELKELRKRDEVSRVERDRLLSEIEQQKLQAELIETEKQRQHQTRVNRLLKSALFASSMGMLLLIASIGMAFYQGRKAVIAASEAASVSSQALFTLGKDIDSLREGLRAARKLDQAIFPHPKTQQMVKTALYQATYGMRVREINRLEGHKSDINSVVISPDNLLIASASSDGTVNLWEKKGKKIHELKGHSRRANSVAFSPDSKIIVSGSADGTVRLWNIDGKLLQTIASGQKIVNSVAFSPDGEIIASAGADKTVRLWNRQGKLLKILSGHSDAVLSVAWAADGNAIASSSSDTTVKLWSRDGKLITTLPGSGEKNTVLSVAWSPDGRMLATASWDHLVRLWSRDGKLLNTLTGHKHVVSNVAFSPDGKTIASASWDRTVKLWNLNGTALETLKGHNDLVSSISFSRDGQMLASASRDTNIKLWRWNYMPLTSIKAHSQEVSQLSYSQQGDLLVSASEDHTVKIWSRDGKLLHQLVGHQKEVWDANLSPDGQFLATASEDNTVKLWSREGKLITTLTGHQEPVLSVDWSPNGERIATASADATVKLWSREGKFITTLTGHQDTVNWVSFSPDGNSIASASDDKTVKIWSKEGKLIRDLSGHSRSVFAVVWSNDGKLLASASLDSTAKLWSPEGKKLKTLTGNGESFITVSFSPDSQTIATLSEDKILLWNRQGNVELAVNAEDETFTTLTFTPDGKALVTGSSTGKVVFRDLADTEINKLLTRGCELLQDYLQNNTKVPKSDRSLCS
>NZ_AP018280.1|WP_096612595.1|4719895_4720480_+|hypothetical-protein
MQYPLQLTFKFWAFSPQISVVDAQGSLQFYVKQKLFKLKEAITVFADAERTRSLYYIKADRIIDFSARYDFTDENGAIIGAVKRQGLKSLWRARYDVFNGESVSFTIQEKNPWVKVADALFQEIPLVGMLSGFVFNPTYLVLRADGAVVMRLEKIPSFLSRQFTIKALDSLNEKEEKQVLLSLMMMLLLEKNRG
>NZ_AP018280.1|WP_096612593.1|4720585_4721254_-|hypothetical-protein
MSPRQLTFTPDSKNLISASSDKTIKFWNLNNGRLVRTLKEHNDWVMTLAISPDSTTLASAGGAYEIDSDTAIRLWDIQTGKLIKTFPRTPEAIGVLAFSPDGKTLVSSTGKLQTNTTINFWDINSGKLVSNISENTVSLIFSKHGEHLLTVSSSYAVDLWNISNGKKIKNLVAGIKLDNDQNIGRIYVSAATLHPDGKTLAIGEGGVLSGYRIGIRQISFDK
>NZ_AP018280.1|WP_096610164.1|4721346_4722489_+|IS4-family-transposase
MLPELYQKHLKSQLSLADYIFLKILIALLQSIKKVSLETLATVLPIPITFESRRKRIQRFLSLPNLSIEKIWFPIVTTWLETEFTSEKIVHVVIDRTNWACVNLFMVSVVWDKRAFPVYFELLPKLGSSNINEQTAIISKVLPVFKNHKICVLGDREFCSIKLANWLRERSIYFCLRIKKNHLVEMQTDIWLELNELGLSPGVSFFLKGVKVTKSQGFTSFNLACKWKRKILGVAPEEGWFILTNLDSLESAIAYYKKRFDIEEMFRDFKSGGYNLEGTNVSGERLIVLITLIAIAYTSATIQGQEIKRKGIQKYVGRVKEYGRTQRRHSSFYIGLYGNNWVNFMEPCIELVTELMKFNINKRKYYQRGLRAMRLILSAS
>NZ_AP018280.1|WP_096612591.1|4722474_4723098_-|hypothetical-protein
MKNFILSNHLLGIQKNFLPIALFLSVIGVNIVCINLVKANISEFNEKNNLTKITSQSKINHNHLLASQNKNTSINQPCKLVNYEAAENFIFTLKGQHNYDIDSLAFTPDGKTLVSGSIYNKINIWDFEKQQLKKVINAGKDGVNTIAISADGSLLAAGGGFSQPDTDTTIKVWNLKTGRMIFKFTGHSQGINALTFLTGRQKSLGGR
>NZ_AP018280.1|WP_096612589.1|4723209_4723869_+|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MEIDKSWETTSDAAVLETAGLTDAQYQKKMQRRKQVQEQRIAEAIPEKGLIIVNTGNGKGKTTAALGMVLRSLGHGYKVAIIQYIKGAWEPAEKKVFSLWEDQLEFYAMGEGFTWETQNRDRDAKIAQAAWQKSLEYIRNPDFRLVLLDEINIALKLGYLAVEDILAGLAEKPAPSHVILTGRGAPPELIKRADLVTEMTLVKHPFREQGVKAQAGIEF
>NZ_AP018280.1|WP_096612587.1|4723895_4724726_-|DUF4351-domain-containing-protein
MSFDNLCKLLSEKYPDRFAKWVLGSEQASVEVLKTELSIEPIRADYVTFLQLKGRILHLEFQTKWESNPPLPLRMLDYWVRLHRLYRLPVTQVVVLLLPPAEGTIIETVFTLESTRHEYRVIRLWEQDPTPLLNDSALLPLASLAASNNSEALLQNVAQRVAQLEPEQRREVSSYVQILAGLKFKKGFIQKMFREGMMRESVIYQDILQEGRQEGREEEARSLILRQLNHKIGILPEQLKLRFGWLSVDELEALGEALLDFTQMADLESWFENYQE
>NZ_AP018280.1|WP_096612585.1|4724807_4725446_+|thiamine-biosynthesis-protein-ThiF
MSIYFHEQLHRTPALMNKLRDFPVTICGAGALGANIAESLARSGCGKLRIIDRDRIEERNLSTQPYYRSDVGAYKTKILANIIYRALGITVEGITKELTAANTTQLLSGSKLVIDAFDNSIARQAVTDNCSNVQIPCLHVGLASDYAEIIWNPAYRVPSSANDDVCDYPLARNLVMLAVAIASETAINFISTQQQQSFTVTLADFAVKPFNI
>NZ_AP018280.1|WP_096612583.1|4725562_4725799_+|hypothetical-protein
MEPNQKELRTVANQEFIEALNQLGDILQESPPDEEEAALVEIQPEESSESESDQKFDLAAWEDAVADIEQYLENRTST
>NZ_AP018280.1|WP_096612581.1|4725872_4726103_-|hypothetical-protein
MSTKNLEFFNAKEITVTLPKHYVQRLYNLLRDNSQGKGTNKDKDSLNLQERVERMLQNPEDRDILAYLDWILKHND
>NZ_AP018280.1|WP_096612579.1|4726555_4727917_-|hypothetical-protein
MSNKLKTINIAIAGHTNTGKTSLIRTLMKSPIGEVGDCANVTKKGEAYYFESLQATFIDTPGFQYAPIVMMCLDAKKENPEFKISEKWESKINYDRDAIAALEDSDVVIYVASLSVVPDDSYQEEISIIRHKSTKIVGVINQYKKQLEATNKDIVDGRVHQWESFFREQSIEQIVVFDAHWDNPIKVNQLYKSIFEILNDEQKSCFTEGLRRFKDRQQKIRKEACKMLSTLIIDCRNEAIVSIPKKDSENKDKIEEAQRQLVEKINHHLYLFVEPVSLLYKIAAENPTTSEEEIIFKIRSEPNWRERAGIGANAAAVLAALSGLLGGIIGFAIVPGTGFINGFAVGSQLGTVIGGAIGSLAIFSDENDTVAIKLDNEQLKIILIKGLAIIWGLSSNGYGRAKELTLQESRYIEEDVSSFRTQQNNINLMSANESKIVEFCEKLLNSLESESKY

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Crispr_ID: NZ_AP018280_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_10

4817727-4817824

Orphan

Consensus_repeat	Method
GTCGTTCCTCCTCCCAATGACGGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_10

>merge|NZ_AP018280|10|4817727-4817824|CRISPRCasFinder
GTCGTTCCTCCTCCCAATGACGGGATGGTTTGTCTATTTGTGGATGACGCTCATCGTCATTGCGATTGCGTAGTCGTTCCTCCTCTCAATGACGGGAT

>NZ_AP018280|10|10|4817727-4817824|CRISPRCasFinder
GTCGTTCCTCCTCCCAATGACGGGAT	GGTTTGTCTATTTGTGGATGACGCTCATCGTCATTGCGATTGCGTA
GTCGTTCCTCCTCTCAATGACGGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096612443.1\|4816164_4816470_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226194
NZ_AP018280.1\|WP_096612439.1\|4819526_4820027_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|225943
NZ_AP018280.1\|WP_096612455.1\|4811594_4812041_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378550
NZ_AP018280.1\|WP_096612459.1\|4809026_4810322_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_AP018280.1\|WP_096612429.1\|4824146_4824509_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612423.1\|4826420_4828469_+\|S-layer-protein	unknown	unknown	gnl\|CDD\|335962
NZ_AP018280.1\|WP_096612441.1\|4818645_4819062_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612445.1\|4815898_4816153_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	unknown	unknown	gnl\|CDD\|274227
NZ_AP018280.1\|WP_096612427.1\|4824756_4825074_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612435.1\|4820978_4821434_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|369489
NZ_AP018280.1\|WP_096612437.1\|4820152_4820809_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_AP018280.1\|WP_096612453.1\|4812083_4814060_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_AP018280.1\|WP_096612431.1\|4822808_4824041_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612447.1\|4815520_4815745_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_AP018280.1\|WP_096612451.1\|4814913_4815096_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612433.1\|4821595_4822573_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_AP018280.1\|WP_096612425.1\|4825308_4826304_+\|homocysteine-S-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376828
NZ_AP018280.1\|WP_096612457.1\|4810899_4811400_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096613513.1\|4814412_4814646_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096612449.1\|4815320_4815524_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374224

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096612443.1\|4816164_4816470_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	3.48204e-17
NZ_AP018280.1\|WP_096612439.1\|4819526_4820027_+\|peptidoglycan-binding-protein	gnl\|CDD\|225943	COG3409, COG3409, Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane].	3.96977e-21
NZ_AP018280.1\|WP_096612455.1\|4811594_4812041_-\|hypothetical-protein	gnl\|CDD\|378550	pfam11068, YlqD, YlqD protein. The structure of a representative of this family has been solved (Structure 4dci) and found to form a tetrameric structure of prefoldin-like architecture with the beta-barrel core and helical coiled coil tentacles. This suggests that this family may act as molecular chaperones.	2.44563e-39
NZ_AP018280.1\|WP_096612459.1\|4809026_4810322_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	9.59128e-161
NZ_AP018280.1\|WP_096612423.1\|4826420_4828469_+\|S-layer-protein	gnl\|CDD\|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	4.28991e-33
NZ_AP018280.1\|WP_096612445.1\|4815898_4816153_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	gnl\|CDD\|274227	TIGR02606, Antitoxin_ParD, putative addiction module antidote protein, CC2985 family. This bacterial protein family has a very similar seed alignment to that of pfam03693 but is a more stringent model with higher cutoff scores. Proteins that score above the trusted cutoff to this model almost invariably are found adjacent to a ParE family protein (pfam05016), where ParE is the killing partner of an addiction module for plasmid stabilization. Members of this family, therefore, are putative addiction module antidote proteins. Some are encoded on plasmids or in prophage regions, but others appear chromosomal. A genome may contain several identical copies, such as the four in Magnetococcus sp. MC-1. This family is named for one member, CC2985 of Caulobacter crescentus CB15. [Cellular processes, Other, Mobile and extrachromosomal element functions, Plasmid functions].	4.31801e-10
NZ_AP018280.1\|WP_096612435.1\|4820978_4821434_-\|histidine-kinase	gnl\|CDD\|369489	pfam07730, HisKA_3, Histidine kinase. This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.	1.56881e-05
NZ_AP018280.1\|WP_096612425.1\|4825308_4826304_+\|homocysteine-S-methyltransferase-family-protein	gnl\|CDD\|376828	pfam02574, S-methyl_trans, Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.	1.14494e-39
NZ_AP018280.1\|WP_096612453.1\|4812083_4814060_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_AP018280.1\|WP_096612447.1\|4815520_4815745_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	8.75647e-18
NZ_AP018280.1\|WP_096612433.1\|4821595_4822573_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.46865e-52
NZ_AP018280.1\|WP_096612437.1\|4820152_4820809_-\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.41131e-77
NZ_AP018280.1\|WP_096612449.1\|4815320_4815524_+\|hypothetical-protein	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	8.3563e-13

>NZ_AP018280.1|WP_096612443.1|4816164_4816470_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSNICRFTAPASRDIESIIDYVADNCSFDAAESLLKKINQKCQNLANFPNVGRRRDELSPFLRSFPVDNYLIFYRQIEDGIEITRVISGYQDLDALFDKDS
>NZ_AP018280.1|WP_096612445.1|4815898_4816153_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin
MSISLTPELEQFIQNQVASGKYTSTEEVIIAGIKLLEERENIYKGRFEELKREIAIGVEASERGEIIDGEIVFRQLEQKLQQRR
>NZ_AP018280.1|WP_096612447.1|4815520_4815745_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MTRIRRMGADEVERILQSYGFELISQKGSHRKWRNDDRQLQVIVPYHKGRDLPIGTLRNIMIGADIPEFEWKTD
>NZ_AP018280.1|WP_096612449.1|4815320_4815524_+|hypothetical-protein
MKWRVVLEPDPETGEWAVWCPELPGCTSAGDTEEEALENIREAIQLYLETDPIKLAPGAIFREVMVG
>NZ_AP018280.1|WP_096612451.1|4814913_4815096_+|hypothetical-protein
MNLIDGLFLTAANAIVCIVFPKLLYTILAAKRQQREVVLETPKSTQADTEITSEVPSYPY
>NZ_AP018280.1|WP_096613513.1|4814412_4814646_+|hypothetical-protein
MDILFLTLVSAAACIALPRLISMILALGGKPIQKHHVITLQNARQEVTSFPFCTTYSLTRTPACKFSPHFCGQCSHQ
>NZ_AP018280.1|WP_096612453.1|4812083_4814060_-|long-chain-fatty-acid--CoA-ligase
MVRTSADPNFFSTYTEQERIYAKDLIDYADVETLPEIWSLVATRYPDIVAVCDPHAKPEVFFTYTQLHEKIQCFAAGLQVLGVKEGNRVALISDNSPSWLIADQGIMMAGAVNAVRSSLAEREELLFIISNSGSTALVLENLKTLKKLREGLHELPIEFVVLLSDEQPGSDESLKVLNFSQLMEIGQQHHLQPVQRQRQDLATLIYTSGTTGKPKGVMLTHANLMHQVTSLGSIVRPKPGDTVLSILPTWHSYERSCEYFLFGQACTQIYTNLRSIKSDLKKFAPNYIIAVPRLLESIYEGIQKQFRDQPASKQRLVNNLLGISEKYIKARRIAQGLDLENFQASALQRLLASLKATVLSPLHAVGDKLVYSKVREATGGKIKQMVSGGGALPRHIDLFFEIVGVEILVGYGLTETSPVTHVRRVWRNVRGAAGQPVPGTEIKIVDAETRKPLAVGERGLVLLRGPQIMQGYYQNPEATAKAIDSQGWFDSGDLGWVSEKNDLILTGRAKDTIVLTNGENIEPQPIEDACLRSPYIDQIMLVGQDQRCLGALIVPNVEALEKWAESQDLKLCIQEDNVTLAGSQKINLESKIVQDLFRQEMNREVQNRPGYRLDDRINPFRLILEPFSIENGLMTQTLKLRRHVVMERYRDTINNMFA
>NZ_AP018280.1|WP_096612455.1|4811594_4812041_-|hypothetical-protein
MDVSKQLLLKRAVNVKAIVTPLWKEEVQQQLQAQINQIDQQLQQIDIQGQRAVSEIQKQSMQPPGPQTLQQIDNIQAQVNEKKSELLEQKNQSLQNLQQVQLLELDQEVNQFQMEGFFRVEPGDNLISKLQVEVVIRDGVVEEIRGDI
>NZ_AP018280.1|WP_096612457.1|4810899_4811400_+|hypothetical-protein
MSAKLKIFLILVLGIFATAAVGSIFTNRQLITAISANQNVQAQQPPVAIQTTSLAVNPERAKYKTIPLENINSGLQGTDPASLAMNVFDTAQGDRTKRQVEVVYPYPNQALVTITQNKPTRNQNYRSAVRYRVELTSFGRTIFASSPPMWQIVWVGSQEQCGKRYC
>NZ_AP018280.1|WP_096612459.1|4809026_4810322_-|2-oxo-acid-dehydrogenase-subunit-E2
MSIHEVFMPALSSTMTEGKIVSWVKSPGDKVEKGETVVVVESDKADMDVESFYEGYLAHIIVPAGDSAPVGNAIAFIAETEAEIADAVAKASSISTPVVAPLAAASKGSSTTAVVEPVTTSQNGSNHREGRIVASPRAKKLAKELKVNLNAIAGSGPFGRIVAEDVETAAGKVSAPPAVTPITAPTTTPISTPAAPKPLPTPVAAVVPGQTTPFTTLQNAVIRGMVASLAVPEFRVSYTITTDALDKLYKQLKSKGVTMTALLAKAVAVTLQKHPLLNASYSDQGIVYHSGINIAVAVAMDDGGLITPVLQNADQVDIYSLSRNWKSLVERARAKQLQPEEYTTGTFTVSNLGMFGVDTFDAILPPGQGSILAIGASRPQVVATTDGMFGVKQQMQVNITCDHRIIYGAHAAAFLQDLAKLIETNTQSLTM
>NZ_AP018280.1|WP_096612441.1|4818645_4819062_-|hypothetical-protein
MEPITAATIATLAFTKVFEKTIEKFTEAALQKMDELRKKIFDKFRGNVKVETALRAAEKGSKKDLDTVAAYLQVLMHEEPLFAEEIRAIARDIKAGEKQDNSTMTQINQDNARGWQTKVDGGTAYIGENTINQAPPNS
>NZ_AP018280.1|WP_096612439.1|4819526_4820027_+|peptidoglycan-binding-protein
MTTATSILPLKEGSVSEGVSIIQGFLTTLKLYSAKIDGSFGAKTKEAVIKFQGANGLTKDGIVGNNTAIALDNESWAAQQPVLKEGAKGADVEAFQGLYNSYFGTLAVDGIFGAKTKAEVIKFQKSRNLTADGIVGAKTWSSLRSLTTHDIPTEDRISFIFEPQGC
>NZ_AP018280.1|WP_096612437.1|4820152_4820809_-|DNA-binding-response-regulator
MIRLLLVDDQSLVRQGLKAILSLETDLEIVGMAENGEEAIAQVEALQPDVILMDVRMPVMNGANATRIICEKYPQMKILVLSTYDEERDVSDVIRAGAKGYLLKDMPSEELVNAIRCVNSGYAQLAPGLLERIVNQPSSPVNTSPATSPPLTELTTRELDVAKLVATGATNQEIADELYISESTVKTHINSIFHRLNLKNRAQLAIYANSALSHTTSS
>NZ_AP018280.1|WP_096612435.1|4820978_4821434_-|histidine-kinase
MFYRYQAKYMLAVLLLVAFLLTLIWQLVNAVHANHQKHCQLILFEQQINLYTSQIVKMTEIQEKNQNLVNLYNALGQSIAALNIQLQVAQKCWFINPEQAHESLTDASQLSASLMYEVRQIVKEMSVEQVIRENSKCYASQAEIYLLSTKY
>NZ_AP018280.1|WP_096612433.1|4821595_4822573_-|sensor-histidine-kinase
MVEELYTPEELAQMHDSLWQCVLQFANLSAKQERDRIARDLHDSLGHSLTALNFQLQTAMKLCQPNPSQAQEFLTEAHRLVGIATREVRQSVKALRSEAVETQSLETLIESLVSDFERTTGILPEVNIDLPIALSSYLVTPVYRITQEALNNIRKYAKATAVQINICTTPTGIYLIIKDNGCGFDVTQVSGGYGIQGMKERVAVLQGRLQLESKPGEGCCISVGIPMQISRLPEIISHEENTLIQPNLPSDLSQSNLSQSDFSQKDAIAESQLTTLYNFTNLEAVNITNTSTNFDTEDIQQEQEFLISSSRMVKISEWQPLNLNA
>NZ_AP018280.1|WP_096612431.1|4822808_4824041_+|hypothetical-protein
MPSINLLAVFNPSNYWRSGYVTVPWQPIYQEFQIPPVELTLSDLRDLSRTPLCAQVDCIDPKNSERDRLVFSLPQPIPPGSPDNMLASGFIKVDRGKAIPQGLSEASVEVVYGANGQERGVRLSNSRLIVWFSLIPAPEDSDRNWFSGSATSIQLDHQEILDPFLAARGEWLGQDPEKRCMQVAGIQLPGAGEPKLPYYQVHLYNHSYRLISQSSGCVRASITIASEPFDYMGIDPNTGYNRHLVCELYRVISLYAGADFLVEELFVKGKPKTNEGAILDSSEVIYLDFGLRYFAHMNMGHTEDIQQVFPVPDWFAIGSTEPPYPAYGLASNLHIESLIHPYGGNLSGLSWQLLPGKSATCLHLFMRNQANDFDTRIGHLWYEMIHSPLRAEIYDTGLKSKVQKQIFAQL
>NZ_AP018280.1|WP_096612429.1|4824146_4824509_-|hypothetical-protein
MFNNKRFLALSIAGIAGLATILATASQVQAERSFTTNKAEQGYSVAQIYRYPGEGRYPGDDRYPGEGRYPGNPNRVVLARMWERERMRRYHECRYRFNHRPWMCDRILRERNPYEGHRWN
>NZ_AP018280.1|WP_096612427.1|4824756_4825074_+|hypothetical-protein
MSHLQKVINITLLTTVLFAPAAMAQQQSLSIPTDRLEQQVPCKDRHGKPVPCPWQKPSQTDLTTGDTSTEKKPNPCNPKKGQPVDTKACRDYINGNPKPPTQPKS
>NZ_AP018280.1|WP_096612425.1|4825308_4826304_+|homocysteine-S-methyltransferase-family-protein
MARYRDSLPQLSSDLFLTDGGLETTLIFREGITLPDFAAFDLLKHRQGYQALEQYFRTYASMAQKYGVGFILESATWRANPDWGRKLGYDHQSLAEMNRRAIALLDEIRQEYETEKTRMVISGCIGPRGDGYVPTEVMTENEAELYHRQQIQTFRDTDADMVTAITMNYPEEAIGITRAAKLAEMPVAISFTVETDGKLPTGQSLKDAIEQVDTVTDYTPVYYAINCAHPTHFADVLAANEPWVKRIRGIRANASIKSHAELNESLELDDGNPEELGSQYHQLLNNLKHLNILGGCCGTDERHVEAICKAVLPLLWAHLSNTQTINRYLFT
>NZ_AP018280.1|WP_096612423.1|4826420_4828469_+|S-layer-protein
MSDIGLLMAGILTTGQATLSELPEEPAIQPDSVQESDKEEKAVNTEVSSQSSLKNTIAPPELTLSENSSQPAISELTQKQKKLLNKITEKVKRDGEIQELSQSPHLPITASPNHRVSQSPSLPITAPPPYPTSPSPTPEFIDSTSLDSKFLDSISTDSKSPDSTFPDSKFPDSTSTDGMSQVTSVSQLGDIDSSHWAFSAVQSLVERYGCVAGYPDGTFKGNRSMTRYEFAAGLNACLDKINELIATNQENLAKQEDLIELQRLQAEFQPELTILQARLNNLEERTAELEANQFSTTTKLYGQAIFSVQGTNEGDIFLYRGEETPRKAETNVTFTSSSQLTLATSFNGRDLLLTGLAAGNLGSSTQAVSTNMGRLGFESDTGNNDVYLNELSYRFPVSDNFGVVVGTAGVNPINTFRGINPLEGSGDGAISLFGQRNPILAIGSSTSGVGFDWQISDRISLQGIYSAQIASFPGDINVGGLFGGNYTAGAQITVAPTDNVDIGVHYLFNHSPDGNLRTGVGDTQLVSPFAPQTTFDTHAVGATVAWRVNPNLQLGGWGGWTASNPVNLSGTVETTNWALFAAFPNLFRPGNLGGLIVGQPPKITSSTLPDGYNLPNFALPDFETGGGKGGREDTSLHLELFYRAQINDNISLTPGLFVIFNPNHNNDNDTLVVGAMRATFRF

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Click the colored protein region to show detailed information

Crispr_ID: NZ_AP018280_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_11

5385395-5385521

Orphan

Consensus_repeat	Method
CCAAAATTGGGGTTGGGAATCTGCTGGTTGTAGGTTGGATTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_11

>merge|NZ_AP018280|11|5385395-5385521|CRISPRCasFinder
AGATAATTAGGGTTAGCAATTTGCTGACCTAATGTTGGATTTGGGAAATTATTTTTACCAAAATTGGGGTTGGGAATCTGCTGGTTGTAGGTTGGATTGGGAATTTGTTGGTTGTAAGTCGGGTTGG

>NZ_AP018280|11|11|5385395-5385521|CRISPRCasFinder
AGATAATTAGGGTTAGCAATTTGCTGACCTAATGTTGGATTTG	GGAAATTATTTTTACCAAAATTGGGGTTGGGAATCTGCTGG
TTGTAGGTTGGATTGGGAATTTGTTGGTTGTAAGTCGGGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096611614.1\|5374896_5375493_+\|DUF3177-domain-containing-protein	unknown	unknown	gnl\|CDD\|371497
NZ_AP018280.1\|WP_096611592.1\|5387431_5388058_+\|2-hydroxy-3-keto-5-methylthiopentenyl-1--phosphate-phosphatase	unknown	unknown	gnl\|CDD\|319826
NZ_AP018280.1\|WP_096611604.1\|5381364_5382258_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611588.1\|5388855_5389146_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_AP018280.1\|WP_096611617.1\|5374220_5374442_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367139
NZ_AP018280.1\|WP_096611598.1\|5384274_5384895_+\|DUF938-domain-containing-protein	unknown	unknown	gnl\|CDD\|253548
NZ_AP018280.1\|WP_096611600.1\|5383089_5383851_-\|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|131644
NZ_AP018280.1\|WP_096613443.1\|5396465_5397551_+\|recombinase-RecA	unknown	unknown	gnl\|CDD\|236476
NZ_AP018280.1\|WP_096611612.1\|5375649_5375940_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611586.1\|5389268_5390465_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224563
NZ_AP018280.1\|WP_096611606.1\|5379382_5381083_+\|solute-carrier-26-family-protein	unknown	unknown	gnl\|CDD\|273284
NZ_AP018280.1\|WP_096611584.1\|5390494_5391226_-\|JAB-domain-containing-protein	unknown	unknown	gnl\|CDD\|178801
NZ_AP018280.1\|WP_096611602.1\|5382557_5382749_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611582.1\|5391965_5393816_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237050
NZ_AP018280.1\|WP_096611610.1\|5376747_5378370_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_AP018280.1\|WP_096611580.1\|5397657_5399244_-\|peptidase-S8-and-S53-subtilisin-kexin-sedolisin	unknown	unknown	gnl\|CDD\|173813
NZ_AP018280.1\|WP_096613445.1\|5394473_5395781_+\|glycoside-hydrolase-family-10-protein	unknown	unknown	gnl\|CDD\|224563
NZ_AP018280.1\|WP_096611594.1\|5386772_5387315_+\|acireductone-dioxygenase	unknown	unknown	gnl\|CDD\|224704
NZ_AP018280.1\|WP_096611590.1\|5388116_5388791_+\|methylthioribulose-1-phosphate-dehydratase	unknown	unknown	gnl\|CDD\|274521
NZ_AP018280.1\|WP_096611608.1\|5378818_5379238_+\|cytochrome-B6	unknown	unknown	gnl\|CDD\|223795

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096611614.1\|5374896_5375493_+\|DUF3177-domain-containing-protein	gnl\|CDD\|371497	pfam11375, DUF3177, Protein of unknown function (DUF3177). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	6.76733e-96
NZ_AP018280.1\|WP_096611592.1\|5387431_5388058_+\|2-hydroxy-3-keto-5-methylthiopentenyl-1--phosphate-phosphatase	gnl\|CDD\|319826	cd07524, HAD_Pase, phosphatase, similar to Bacillus subtilis MtnX; belongs to the haloacid dehalogenase-like superfamily. Bacillus subtilis recycles two toxic byproducts of polyamine metabolism, methylthioadenosine and methylthioribose, into methionine by a salvage pathway. The sixth reaction in this pathway is catalyzed by B. subtilis MtnX: the dephosphorylation of 2- hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HKMTP- 1-P) into 1,2-dihydroxy-3-keto-5-methylthiopentene. The hydrolysis of HK-MTP-1-P is a two-step mechanism involving the formation of a transiently phosphorylated aspartyl intermediate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	9.94049e-51
NZ_AP018280.1\|WP_096611588.1\|5388855_5389146_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.33219e-25
NZ_AP018280.1\|WP_096611617.1\|5374220_5374442_+\|hypothetical-protein	gnl\|CDD\|367139	pfam02672, CP12, CP12 domain. The function of this domain is unknown, it does contain three conserved cysteines and a histidine, that suggests this may be a zinc binding domain (Bateman A pers. observation). This domain is found associated with CBS domains in some proteins pfam00571.	3.79932e-28
NZ_AP018280.1\|WP_096611598.1\|5384274_5384895_+\|DUF938-domain-containing-protein	gnl\|CDD\|253548	pfam06080, DUF938, Protein of unknown function (DUF938). This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.	1.02261e-97
NZ_AP018280.1\|WP_096611600.1\|5383089_5383851_-\|PEP-CTERM-sorting-domain-containing-protein	gnl\|CDD\|131644	TIGR02595, conserved_hypothetical_protein, PEP-CTERM protein-sorting domain. This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures].	0.000794475
NZ_AP018280.1\|WP_096613445.1\|5394473_5395781_+\|glycoside-hydrolase-family-10-protein	gnl\|CDD\|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	1.46889e-136
NZ_AP018280.1\|WP_096611586.1\|5389268_5390465_+\|hypothetical-protein	gnl\|CDD\|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	6.20078e-89
NZ_AP018280.1\|WP_096611606.1\|5379382_5381083_+\|solute-carrier-26-family-protein	gnl\|CDD\|273284	TIGR00815, Sulfate_transporter, high affinity sulphate transporter 1. The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions].	4.33188e-166
NZ_AP018280.1\|WP_096611584.1\|5390494_5391226_-\|JAB-domain-containing-protein	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	5.02954e-103
NZ_AP018280.1\|WP_096613443.1\|5396465_5397551_+\|recombinase-RecA	gnl\|CDD\|236476	PRK09354, recA, recombinase A; Provisional.	0
NZ_AP018280.1\|WP_096611582.1\|5391965_5393816_+\|threonine--tRNA-ligase	gnl\|CDD\|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_AP018280.1\|WP_096611610.1\|5376747_5378370_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_AP018280.1\|WP_096611580.1\|5397657_5399244_-\|peptidase-S8-and-S53-subtilisin-kexin-sedolisin	gnl\|CDD\|173813	cd07488, Peptidases_S8_2, Peptidase S8 family domain, uncharacterized subfamily 2. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.37598e-68
NZ_AP018280.1\|WP_096611594.1\|5386772_5387315_+\|acireductone-dioxygenase	gnl\|CDD\|224704	COG1791, COG1791, Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown].	5.13199e-50
NZ_AP018280.1\|WP_096611590.1\|5388116_5388791_+\|methylthioribulose-1-phosphate-dehydratase	gnl\|CDD\|274521	TIGR03328, dehydratase-enolase-phosphatase_complex_1, methylthioribulose-1-phosphate dehydratase. Members of this family are the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine. [Amino acid biosynthesis, Aspartate family].	4.18892e-61
NZ_AP018280.1\|WP_096611608.1\|5378818_5379238_+\|cytochrome-B6	gnl\|CDD\|223795	COG0723, QcrA, Rieske Fe-S protein [Energy production and conversion].	4.59733e-23

>NZ_AP018280.1|WP_096611598.1|5384274_5384895_+|DUF938-domain-containing-protein
MTNKQFAPATQRNREYILEVLLQILPASGTILEIASGTGEHATYFAPLLKPRKWLPSDPNPIARDSITAWSQEVASDNLYPPIELDASLPVWNVESMDLQELSICAIANINMIHISPWAACLGLMAGAGRILPSGGILYMYGPYKLDGKHTAPSNEAFDASLKSQNPEWGVRNLDDVIAAAKAQKLNLLKTVQMPANNLSVIFQRD
>NZ_AP018280.1|WP_096611600.1|5383089_5383851_-|PEP-CTERM-sorting-domain-containing-protein
MLLAKKALSLALISTAATAIASVSYTGSAQALSMTYNSGTYRDASIKNEGAFSTEVNKTGYETFDFNNGAVPGNDKVKYSFSNGSYSTTAYSGQTGIYSDMWAPAGVKAEVNDSKYLAVFQGNNTIIEALGGKVFNYFGFDAGALSGGNTIEFFKAGTLVKQLTYEMMNSLATVSATQHGGQKNAFFEIFSTSELDNFDKIVLSQVGGGGFETDNHTFRVGKGAYSIPEPGVVFGLATVSGMFLRSRKKQKTA
>NZ_AP018280.1|WP_096611602.1|5382557_5382749_+|hypothetical-protein
MDLVQFVIVLIVVGVLLWLVNNYIPMDRKIKQILNIAVVIAVVLWVLKVFGVLGSLSGIRIGK
>NZ_AP018280.1|WP_096611604.1|5381364_5382258_+|hypothetical-protein
MKWQQLILAFITTICLIFAGNALAQTDININNTNLIRFGGSVTVPENQVVENALAFGGSVTVSPNARVLDTAIAFGGDVILKQGARVEADAYSFGGKILQEPGATIGGEKATFSDRRGMMYGSNRGKSSFFAHYFFSAIFRISAAVVAAILGLIILHTNPQFLQNLATKLHQHPSLTALWGMGAIISFVFVSVFLAITLIGIPLIPLLTLTAIITSLVGSLGVALFVGQRLVSNDDSRSERLRQKSLQQHFLVGLAILTVLALIPFFGGLVVFLVNLFGLGVILLWKFGTEKPQIAT
>NZ_AP018280.1|WP_096611606.1|5379382_5381083_+|solute-carrier-26-family-protein
MLKKYQVTLLRIPGLKQLLSYQRAWLCGDVLAGVTVAAYLIPQCMAYGELAGVQPVVGLWAILPPMIIYTLLGSSPQLSVGPESTTAVMTAAAIAPLVAVNGGNYASLASLLALLVGIVCIIGYFTKLGFLADLLSKPILVGYMAGVAVIMITGQLGKISGISLEANTVFGEVVEFFGKLEQIHQPTLILGLMVLAFLFIVQRRFPNAPAPLLAVLLATASVALFHLERQGVAVVGEIPAGLPHLTLPQLSTQEISTLLASALGIAIVGYSDNVLTARAFATRNHYKIDSNQELLALGTSNLGNGLMQGFPVSSSGSRTAIADSLGSKSQVFSLVALVVVILVLLFLRPLLAQFPKAALGAIVIYAATKLIEIPEFLRLARFRRSELFVALMTTVGVLFTDILVGVGIAVGLSVIDLFARVARPHDAVLGEVPGLPGLHDIEDWEGGKTFPGLLIYRYDAPLCFANVENFKRRALAAIESETTPVEWFVLNTEAIAEVDITAIDTLTEFHSELTARGITFAMTRVKQDLYKQLKRSHLLEKIGSEHIYLTLHTAIAAFQAREQHFH
>NZ_AP018280.1|WP_096611608.1|5378818_5379238_+|cytochrome-B6
MNRRDFITLFGIGGIASSLPLAIAACSPEKSTTTISKDWQNIGTVAELDKDGQLLNENSPVGAVLVVGTSKAKNIVAVNPTCTHKGCKVDWRATENKFLCPCHQSAFAGDGKVLEGPATKPLATYAVKIEGDAVLAKPV
>NZ_AP018280.1|WP_096611610.1|5376747_5378370_+|glutamine-hydrolyzing-GMP-synthase
MNTVVTLPTEEAHQTSQSIRLVNRQIIVILDFGSQYSELIARRIRETHVYSEVLSYRTTAEQLRQLNPKGIILSGGPSSVYDDNAPKCDPEIWELGIPIMGVCYGMQLMVQQLGGEVSRATRGEYGKASLYIDDPTDLLTNVEDGTTMWMSHGDSVQKMPSGFELLAHTENTPCAAIASHEQKLYGVQFHPEVVHSLGGLALIRNFVYHICDCEPTWTTEAFVEEAVREIRARVGKKRVLLALSGGVDSSTLAFLLHKAIGDQLTCMFIDQGFMRKLEPERLMKLFKEEFHIPVEYVNARDRFLNALTGVSDPEEKRRIIGHEFIRVFEEESKRLGPFDYLAQGTLYPDVIESADTNVDPKTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRNIGLPEEIVNRHPFPGPGLAIRILGEVTAEKLNILRDADLIVRQEINQNGLYHDYWQAFAVLLPIKSVGVMGDQRTYAYPIVLRIVTSEDGMTADWARVPYDVLEMISNRIVNEVKGVNRVVLDITSKPPGTIEWE
>NZ_AP018280.1|WP_096611612.1|5375649_5375940_+|hypothetical-protein
MIGKRLEQYTIKHPQQVLLVTVEINDEEDQIAIFKGFSSSLVRPTNFDPDVPVLPDDAKVLSIDIVASPYNPDAPRYLEQNLSWDIMQVRLSNLGM
>NZ_AP018280.1|WP_096611614.1|5374896_5375493_+|DUF3177-domain-containing-protein
MMKDVWFRWLVWLDFRLAILFTLVIPLGLFIGAFLQKNQTMQHLLAIYWRVASLFAITLYLAIAQYQVSFISGLMARILIPLSLWFWVDLNDEIEYQPNSLMKLVLNSWRWATTFYCALSAIASIPFVGCAFSAINLKSNYCQVWFEAPLAFKNIFHQNTTAAFLGILGILGLILYVIFLGYFVIFKLGKQGRTAIEQ
>NZ_AP018280.1|WP_096611617.1|5374220_5374442_+|hypothetical-protein
MSDIQDKIQSELEQARAVCDITGANSAECAAAWDAVEELQAEASHQRQQKQKNSLEQYCDDNPEAVECRVYED
>NZ_AP018280.1|WP_096611594.1|5386772_5387315_+|acireductone-dioxygenase
MAILKMENGSTYTDLEEIVRELAPLHITLNYWSVGDNQELQELLAQDSLTDTEKDTVLQGLDNYFEQLKQSAGYTSRDLIVLHPEIPNLDMMLAKFEKVHTHADDEVRYIVAGEGIFGFVRPDGSQVELTVQPQEYINVPAGTEHWFYLTPGKRIKAVRYFIGTDGWVPEYTGTEIRVQN
>NZ_AP018280.1|WP_096611592.1|5387431_5388058_+|2-hydroxy-3-keto-5-methylthiopentenyl-1--phosphate-phosphatase
MRRIVFCDFDGTITAQETFVAVLKEFAPELAADLIPQMYALKITLREGVRRILESIPSSRLSEIIEFTRNQPIREGFPELLDFLDSQDIPFVVVSGGLREMVEAVMGDLVQRVKAIHAIDIDTSNTNFQVISPYEGETELVDKVKVMEMYPADVKIAIGDSVTDLNMALSTPLVFARDRLAQYLSDRNKDYIAWNDFFDVLHALKSKI
>NZ_AP018280.1|WP_096611590.1|5388116_5388791_+|methylthioribulose-1-phosphate-dehydratase
MSQQQLLDNLSIDCDPRLELCQAASHFYKQGWMLGTAGNLSAKLNDGSFWITASGKSKGELKSEDFVRIYPDGTVLAVTPELQLSAKPSAETSIHQAIYELFPEANACYHVHSVEANLVSNFVVGDELPLPPLEMLKGLGIWEENPNCTMPLFTNHAHVPQIAEDIRNYFHSQKSQHQSTQVPALLIRNHGITVWANSPKTAFHYIEVAEYIFRYLVAAKKAGI
>NZ_AP018280.1|WP_096611588.1|5388855_5389146_+|antibiotic-biosynthesis-monooxygenase
MTIHVVARVITLPNKIEEFKALALNLVEATRQEAGCIKYELLQNQSDATDFTFVEAWESEAVWNLHLNTPHFLDAVSQLDGLVASAPDIRSYKLLK
>NZ_AP018280.1|WP_096611586.1|5389268_5390465_+|hypothetical-protein
MVGRYIKDIKLFLWRSQSQKRWLSLALVSLLLVTLFWQAPTINQSQIANNEIRGVWMTNYGAALSYYTSRLDEVIANIAKRRLNTIYPAVWNRGYTLHPSPVAKSASGYSQDYMTSLPLFPFQDALSGLVEQAHRQKLRIIPWFEYGLLIPKNHSIVKRHPNWLTANQRGETVSSDGMSWLNPCHPEVQKFITDLIVDVVKRYPVDGIQLDDHFALPVEFGYDAYTRKLYRQEHNGNSPPQNPKNPEWMAWRAGKLTQLMAKISKAVREENHDVIISLSPNSLNFAYNKYLQDWGKWVDRGLLDEVIVQIYREDLTAIKHELNKSELLNIRKKVPIAIGLYTGPFLSPKSIKNLQKEIEIVQNYNYDGVSFFCWETTLWFFKGGSDTELENSLRKVFT
>NZ_AP018280.1|WP_096611584.1|5390494_5391226_-|JAB-domain-containing-protein
MTYCLRIADMAESERPRERLLSNGPKVLSTAELIAILLGTGQGAGKLSAVGLGQYILRELGKNDRDPLAVLRDVTPAELMHIQGIGPAKATSILAAVELGKRTFQANPSDRTPIDSPAAAAAVLSQDLMWQLQERFAIILLDVKNKMLARQIITIGTATETLAPPREIFREALRQGATRLIVAHNHPSGNVEPSREDIELTRQLLGGAQFLGIPLLDHIILGNGSYQSLREITSLWDECPQGD
>NZ_AP018280.1|WP_096611582.1|5391965_5393816_+|threonine--tRNA-ligase
MSPNSPPQQSEPAEIVEKVEKMYLPRTSESENLKKIRHTTSHVMAMAVQKLFPKAQVTIGPWIENGFYYDFDSPEPFTDKDLKAIYKEMVKIINRKLPVIREEVSREEAEKRIQAIKEPYKLEILGDIKTEPITIYHLGDQWWDLCAGPHVENTGDLNPKAIALESLAGAYWRGDETKAQLQRIYGTAWESPEQLAEYQRRKEEAQRRDHRKLGKELGLFIFSDLVGPGLPLWTPKGTLLRSLLEDFLKQEQVKRGYLPVVTPHLGRVDLFKTSGHWQKYKEDLFPMMAESEEAKEQEQGFVLKAMNCPFHIQIYKSELRSYRELPLRYAEFGTVYRYEQSGELGGLTRVRGFTQDDAHLFVTPEQLDDEFLKVVDLILSVIKSLKLDSNFKARLSFRDPNSDKYLGSDEAWNQAENAIRRAVETLGMDHFEGIGEAAFYGPKLDFIVKDALEREWQLGTVQVDYNLPERFDLEYVAEDGTRQRPIMIHRAPFGSLERLIGILIEEYAGDFPLWLAPVQAKLLPVSDQFLDYAKDVVAKMQAVGIRAEVDTSGDRLGKLIRNAEKEKIPVMAIVGAKEVETNTLSIRTRASGELGSIAVAEVVEKMKSAIASFDNF
>NZ_AP018280.1|WP_096613445.1|5394473_5395781_+|glycoside-hydrolase-family-10-protein
MILGNFAPVVAQEFPDTQPYPGVPEFPAPQPYPQPPQFPQAQPAPIPIPEPIPQPILQEPEFPSSTESVPQPVPIPQRPRQEIRGVWMTNNDLNVLRDRSKLSEAMSQLRRLHFNTVYPVIYNSGYVMYPSAVAQGRNIQPFIYKGTEGQDIIADVINQSHRQGLLAIPWFEFGFMAPETSELALNHPNWLTQKRDGTKTSISAAGEVAWLNPFHPEVQKFISDLVLEVVTKYDADGIQFDDHMSLPQDFGFDRYTLALYTQETGRPAPTNPQDQTWISWRADKITAFMVQLNKAVKARKPNAIFSVSPNYYDFAYKFQLQDWLNWVRLGIVDELVMQVYRDDLQAFSAKLTRPEILETQQSIPTGIGIMAGLRTRRVPIQQVQSQVRAAQQRGLGVAFFYYESLWDTGPEAPSDRQTGFQAIFPSPALRARAEL
>NZ_AP018280.1|WP_096613443.1|5396465_5397551_+|recombinase-RecA
MAANTADNNNAAKQKALGVVLNQIEKTFGKGTIMRLGDASRMRVETISSGALTLDLALGGGLPKGRVIEIYGPESSGKTTVALHAVAEVQKEGGIAAYVDAEHALDPVYAGCLGVDIENLLVSQPDTGEAALEIVDQLVRSAAVDIVVIDSVAALVPRAEIEGEMGDAHVGLQARLMSQALRKITGNIGKSGCTVIFINQLRQKIGVTYGNPETTTGGNALKYYASVRLDIRRIQTLKKGTEEFGNRVKVKVAKNKVAPPFRIAEFDIIFGKGISTIGCLVDLAEETGILSRKGAWYSYNGENISQGRDNAIKYMEEKPDLIEEIKKLVREKLEMGAVVSANSVRKTAEDEEEEEDEDLEE
>NZ_AP018280.1|WP_096611580.1|5397657_5399244_-|peptidase-S8-and-S53-subtilisin-kexin-sedolisin
MTKKQTWIIFGLSAACLTTPVLALTFSSSIDSWGIDALKLHKAPYNLTGRKIAIGQVEIGRPGKFGVDKAVSNNHALSLVAVFLRNTPAKSNSGVDPHAHNVAGVMVSKDKAFPGVAPNARLYSAAVGATKSQGQPEECLTAQHIATQNGGDVRAINFSFGEPLNRDPRPDAVLDGNALLTMCVDWSSRVHDVLYAIAGNQGKGGIPIPTDNYNAMNVAFSSRREQVFNKVDVSNLAAANEGAAARLAGKEINLGARRSVNILSPGSNIRMLNPDGKVNKVTGTSFAAPHLTGTVALLQEFGDRELKNKRNNWSSASRRHEVMKAILLNSTDKLKDKGDGLRLGMTRTIIDKQNLDWLASDAYQNPKIPLHAQMGAGHLNASRALQQFSAGQWQPNQAVAALGWDYNTVTANAFVDYVLAKPLKANSFVAVTLTWDRLVELEDKNNNQMYEEGENFRDRGLNNLDLYLVQENGSTVANCASISEVDSIEHVFCPVPASGSYKIRVQYKQQANEPKQAYALAWWTAPVN

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Crispr_ID: NZ_AP018280_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_12

5448361-5448464

Orphan

Consensus_repeat	Method
ACAGCAGCTTGACGCTGGGCTATTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_12

>merge|NZ_AP018280|12|5448361-5448464|CRISPRCasFinder
ACAGCAGCTTGACGCTGGGCTATTTCTTCAGGACGGGAACCGCTTTCCATGAGTTGAAAAGAAGCTCTCGCCTCCGCCACAGCAGCTTGACGCTGGGCTATTTC

>NZ_AP018280|12|12|5448361-5448464|CRISPRCasFinder
ACAGCAGCTTGACGCTGGGCTATTTC	TTCAGGACGGGAACCGCTTTCCATGAGTTGAAAAGAAGCTCTCGCCTCCGCC
ACAGCAGCTTGACGCTGGGCTATTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096611538.1\|5437396_5437945_+\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
NZ_AP018280.1\|WP_096611514.1\|5455189_5456206_+\|LD-carboxypeptidase	unknown	unknown	gnl\|CDD\|132882
NZ_AP018280.1\|WP_096611536.1\|5438090_5439476_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP018280.1\|WP_096611530.1\|5442263_5442773_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611508.1\|5459207_5460281_-\|GHMP-kinase	unknown	unknown	gnl\|CDD\|223231
NZ_AP018280.1\|WP_096611502.1\|5461794_5463543_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NZ_AP018280.1\|WP_096611528.1\|5444607_5445240_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|379137
NZ_AP018280.1\|WP_096611506.1\|5460353_5461241_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379240
NZ_AP018280.1\|WP_096611512.1\|5456341_5458249_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|310523
NZ_AP018280.1\|WP_096611504.1\|5461489_5461729_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611518.1\|5450584_5451895_+\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NZ_AP018280.1\|WP_096611524.1\|5446364_5447582_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NZ_AP018280.1\|WP_096611540.1\|5435774_5437349_+\|NB-ARC-domain-containing-protein	unknown	unknown	gnl\|CDD\|368582
NZ_AP018280.1\|WP_096611520.1\|5449468_5450332_+\|DUF1092-domain-containing-protein	unknown	unknown	gnl\|CDD\|368938
NZ_AP018280.1\|WP_096611510.1\|5458330_5459221_-\|UTP--glucose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|224131
NZ_AP018280.1\|WP_096611534.1\|5439553_5440900_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP018280.1\|WP_096611516.1\|5452445_5455154_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|238504
NZ_AP018280.1\|WP_096613432.1\|5443042_5444329_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_AP018280.1\|WP_096611532.1\|5441074_5441968_+\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|239783
NZ_AP018280.1\|WP_096611526.1\|5445401_5446160_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096611538.1\|5437396_5437945_+\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	1.31709e-81
NZ_AP018280.1\|WP_096611514.1\|5455189_5456206_+\|LD-carboxypeptidase	gnl\|CDD\|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	1.05871e-112
NZ_AP018280.1\|WP_096611536.1\|5438090_5439476_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.97678e-52
NZ_AP018280.1\|WP_096611508.1\|5459207_5460281_-\|GHMP-kinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	2.27002e-20
NZ_AP018280.1\|WP_096611502.1\|5461794_5463543_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_AP018280.1\|WP_096611528.1\|5444607_5445240_+\|radical-SAM-protein	gnl\|CDD\|379137	pfam13353, Fer4_12, 4Fe-4S single cluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2.72912e-51
NZ_AP018280.1\|WP_096611506.1\|5460353_5461241_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379240	pfam13527, Acetyltransf_9, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.4506e-14
NZ_AP018280.1\|WP_096611512.1\|5456341_5458249_+\|alpha/beta-hydrolase	gnl\|CDD\|310523	pfam05990, DUF900, Alpha/beta hydrolase of unknown function (DUF900). This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.	0.00048491
NZ_AP018280.1\|WP_096611518.1\|5450584_5451895_+\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	6.19263e-101
NZ_AP018280.1\|WP_096611524.1\|5446364_5447582_-\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	5.05068e-71
NZ_AP018280.1\|WP_096611540.1\|5435774_5437349_+\|NB-ARC-domain-containing-protein	gnl\|CDD\|368582	pfam05729, NACHT, NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.	0.000197672
NZ_AP018280.1\|WP_096611520.1\|5449468_5450332_+\|DUF1092-domain-containing-protein	gnl\|CDD\|368938	pfam06485, DUF1092, Protein of unknown function (DUF1092). This family consists of several hypothetical proteins of unknown function all from photosynthetic organisms including plants and cyanobacteria.	6.75984e-156
NZ_AP018280.1\|WP_096611510.1\|5458330_5459221_-\|UTP--glucose-1-phosphate-uridylyltransferase	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	2.55742e-84
NZ_AP018280.1\|WP_096611534.1\|5439553_5440900_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.4629e-55
NZ_AP018280.1\|WP_096611516.1\|5452445_5455154_+\|CBS-domain-containing-protein	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	2.8299e-148
NZ_AP018280.1\|WP_096613432.1\|5443042_5444329_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_AP018280.1\|WP_096611532.1\|5441074_5441968_+\|acetylglutamate-kinase	gnl\|CDD\|239783	cd04250, AAK_NAGK-C, AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the non-acetylated, cyclic route of ornithine biosynthesis. In this pathway, glutamate is first N-acetylated and then phosphorylated by NAGK to give phosphoryl NAG, which is converted to NAG-ornithine. There are two variants of this pathway. In one, typified by the pathway in Thermotoga maritima and Pseudomonas aeruginosa, the acetyl group is recycled by reversible transacetylation from acetylornithine to glutamate. The phosphorylation of NAG by NAGK is feedback inhibited by arginine. In photosynthetic organisms, NAGK is the target of the nitrogen-signaling protein PII. Hexameric formation of NAGK domains appears to be essential to both arginine inhibition and NAGK-PII complex formation. NAGK-C are members of the Amino Acid Kinase Superfamily (AAK).	7.87089e-169
NZ_AP018280.1\|WP_096611526.1\|5445401_5446160_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.54613e-116

>NZ_AP018280.1|WP_096611524.1|5446364_5447582_-|ABC-transporter-permease
MNIIESMKMAGTTLLSNRLRSALTMLGIVIGNASVIAMIGIGEAGQKYVSKQLESLGPNVLFVLPGNEETQRISFEVPRNLVLADAEAIASQVPTVAGVAPELNRRQRVAFKSRNTDVNVIGTTPGFLKVRDFATAKGRFFSDIDMKRNNQVVVLGSKFANKFFGTNNAIGQQIRIKDSKFEVIGVLTEKGSSVGADYDSAVLIPLTTSANRLVGKNSPYGIALDYISASARDGKSVDAAVFQITNLLRLRHKITNEDDFTLRTQKDALSTVGQITGALTIMLAAIAAISLFVGGIGIMNIMLVSVTERTHEIGLRKAIGATQQDILWQFTIEAVIVSAAGGLVGAAIGVSGIVLVGALTPLEAAISPIAIASAVGISGGIGLFFGVFPARRAAKLDPIVALRSI
>NZ_AP018280.1|WP_096611526.1|5445401_5446160_-|ABC-transporter-ATP-binding-protein
MIASSPVRDSHSPIPQKTIIRLENIFKIYGVGETEVRALSEVNLIIEEGEYCSIMGPSGSGKSTAMNIIGCLDRPSSGHYYLDSLDVAQMEDNELAHIRNKKIGFVFQQFHLLQQLTALENVMLPMVYAGIPNSERRERATEALIKVGLENRLNNKPNQLSGGQQQRVAIARSIVNRPVLILADEPTGALDSRTTQEVLDIFTELNASGITVIMVTHEPEVARQTRRIVWFRDGQVVHSNLTPADLNQVATS
>NZ_AP018280.1|WP_096611528.1|5444607_5445240_+|radical-SAM-protein
MTQQKFNPYLSLVEIPPGYLNIMGYVDASEVNGPGSRAVVWVQGCMRECPGCFNEESWSFEINQLISIDNLAENILADSRNQGVTFSGGEPFWQAPALAQLARQVKAAGLTVMSFSGFTLEQLQSDYAPAGAKDLLAELDILIDGAYVESLAINTPDSPVSSSNQRVHIFNPALQDQINWASDQIEVHIFKDGSRLITGYRGGLELTVGE
>NZ_AP018280.1|WP_096613432.1|5443042_5444329_-|phosphopyruvate-hydratase
MIDTAIANIIAREILDSRGKPTVEAEVHLYNGAIGLAQVPSGASTGTFEAHELRDGEKNRYGGKGVLKAVQNVRDAIAPKLINMDVLNQELLDKTMISLDGSANKANLGANAILAVSLAGAKAGAESLGIPLYRYLGGPLANLLPVPLMNVINGGAHAANNIDFQEFMIVPVGASSFREALRWGAEVFATLAKVLDDKGLLTGVGDEGGFAPNLESNQVALELLVAAIEKAGYKPGQEVALALDVAASEFYKEGQYVYDGKPHAPAEFIDYLAQLTSQYPIVSIEDGLHEEDWQNWQALTAKIGSTVQLVGDDLFVTNATRLAKGIEQKAGNSILIKLNQIGSLTETLETIDLATRNGFRSIISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERVAKYNRLLRIEDELGAQAIYAGKVGMGPKGI
>NZ_AP018280.1|WP_096611530.1|5442263_5442773_-|hypothetical-protein
MLSSLFSSKLSSRTSYIILLALGASATLTMSPPASAQSSTIIYQRTTTYDNYRQPRIIYKRHQTHRNYRQPQVTNFIYRSPVYTPFPVNPYKRQVIQNHNNFYPRSYYQQRVIVQPRARKYINNSTGVNTIFLTPNIRNSNIINPRNLNPYRHYYGNPVQRNSGIFFQY
>NZ_AP018280.1|WP_096611532.1|5441074_5441968_+|acetylglutamate-kinase
MVNDTEYIKQAEATRVRVLSEALPYIQQFAGRTVVVKYGGAAMKDSQLKDTVIRDIVFLSCVGLRPIVVHGGGPEINSWLDKLGIEAQFKNGLRVTDAPTMDVVEMVLVGRVNKEIVSLISQAGGKAVGLCGKDGNLITARPQGQEGIGFVGDVSGIDVNILNTLAENGYIPVVSSVAADETGQAYNINADTVAGEIAAALGAEKLILLTDTRGILKDYKNPGTLIPKLDIQEARDLIATGVVAGGMIPKVNCCVRSLAQGVKAAHILDGRIPHSLLLEIFTDVGIGTMLVGSNFMP
>NZ_AP018280.1|WP_096611534.1|5439553_5440900_-|serine/threonine-protein-kinase
MLQPQEILIERYQLQRVLGESVSRQTWLARDLLNREQVVVKLLIASDKLQWDNLRLFEREAKVLRQLDHPYIPEYRDDFVVKKNQEIISFALVQEYIPAKSLKEVLLEGKIFSETEARKIAIALLKILIYLHKLSPPVLHRDIKPSNLLISESEGKKNKIYLVDFGAVQDRAASEGATFTVVGTYGYAPLEQFGGRATPASDLYALGATLVNLVTGIAPADLPQLDSKMQFSHLAQLNPGFVRWLQKMTEPNLEYRFQNASAALEALEINQSAVSTTGVSQDIPHTPILVSKSANKLVVHIPGNKNKFGLVIGGVGLTLWVLFWLPILTMNFPFNPRVIWILIWLILGFVFTAWWTLPSHVESYICLDNRAFEIKWKLFGFTVKTQRGNVSDIDKVYSSKTGNSDMKKLYEIILSLGVNEYYFGSVKNNLSLEESRYIASEIRDWLGL
>NZ_AP018280.1|WP_096611536.1|5438090_5439476_-|serine/threonine-protein-kinase
MLESGQILENNQNHYRLEKKLGQDTSRQTWLATLLDSRSQQTLTSGISHTEQVVLKLLTLSPQIQWDEQKLFEREAQVLQNLNHSRIPKYRDSFIIENLPGSKFSWFVLVQNYIPGISLQEALNQGQRFSESQVEKIAIEILSILVYLHELNPPLLHRDIKPSNLILGADERVYLVDFGAVQDKAVAEGVTFTVVGTYGYVPMEQFAGRAEPASDLYALGATLIHLLTGTSPADLPYENYRIKFTHLVSIDLGLVNWISKLTEPNIRDRIPTAREAITVLENKYNLSPPITNRKPTGSKIQLQKSANSLEIKLPQRGRKSLRTFYLIGLFTPFIWQIFQFTNWSINANGNILFYIIIILLLSSAILKTILLPVFGHTDLYFDREKFEIQWKIFGFCYKRKRGNIIAIEHIYKENPKTALAPMGITIELIKGQKFTTTPLATIERNWLIDEIADWLQFDLNK
>NZ_AP018280.1|WP_096611538.1|5437396_5437945_+|shikimate-kinase
MTDSLKGINVYLIGMMGAGKTTVGRLLARHLHYGFLDTDNVITQAAGKSINEIFATVGEAGFRQFESDILGQVCAYTKLAIATGGGIVIRRENWGYLRHGLVVWLDVPLDLLYSRLAKDTTRPLLQDSDPQGKLKSLLEQRTPLYSQADLHITISECDTPENVAQRIMDAIPSVLKKDNSQN
>NZ_AP018280.1|WP_096611540.1|5435774_5437349_+|NB-ARC-domain-containing-protein
MTASEPHIVEEEFVEAKNNWELEKLYIDLASAKGKALTPVEKKFLRGLLCGFSPAEIASTVYKSKSSSTVRVYLSNGLYKYIEEMLSIQASTNIKVKNWSRVTQLLEKAGYKKTWLKLEAVSNPVTTNYVKKEAAELVNMQTAQQDWGEATDVSVFYGRQNEIAQAQNWIIQERCRLVVLLGMGGIGKTTLSIKLAQKLHSEFDFIIWRSLQLAPPLEVLLNQLIQFLSVNPDMEIADSLEGSISQLIEYLRSARCLIVLDAVDAVLSGDAAESQESVYALAQIKYLPGYEDYGELIRRLGESSHQSCVLLTSRKQPQAIAALSGNSLPVRVLKLTGLGYGDGLEVLKAKGFSNIKQEEYQFLIDWYTGNPLFLKLVGTAIQDLFGGSIYEFIEQGTVVFGEIRAVLDEQFQHLSQLEKQVMYWLALNQDFLSLRKLQRDIVPRVSQRLILEAIELLQRKSLIERQTASFSQTPVLMEYIAECLIEENIRLSGTQASSLLMNQTIFETQLKNYIRELRFNADNI
>NZ_AP018280.1|WP_096611520.1|5449468_5450332_+|DUF1092-domain-containing-protein
MGSIWELDFYSRPILDENQKKVWEVVICESPSDVSTNPDSLFRFTKYCPSTEVNSVWLRTAIEEAIAKVGESPSRVRFFRRQMNNMITKACEDAGIAAQPSRRILVLHNWLGERMEQVYPKEPGYQGGTNPSVRLDAPIPQRLPDALESEKWGFVTLSASDFTDMPEWDISFGEGFPLEMMGITGDMPIPGVLLFSSRALPLAAWISGLELASLRFDESQGGRLVLETGATESWILANIRNPSMKNEAMGFNEAKQKVNGVHFIGIQSSPESESFAGFWLLQDVILP
>NZ_AP018280.1|WP_096611518.1|5450584_5451895_+|TldD/PmbA-family-protein
MGFYQSPLSLLAEQLLELAIKFGAEAAEVYQSRSHSQPVFFEANRLKQIETSQAEGTVLRLWRNGCPGLSVAYGSVEPQAMVERALALSQLNPPEAIELSSSQTSVYPDVGKHVPLEQLVAWGKGAIAQIRNVYPEAMCNGDWECDVETTRLINTKGLDCHYTDTTLSCYLAAEWVRGDDFLSVADGQTQRNYLQPEKLAQQIIQRLHWAQENVIPPSGRVPVLFTSKAADMLWGTVQAALNGKRILEKASPWAERINTPVISSSLTLYQDPVQGPFSCPFDDEGTPTRQLVFIRDGILENFYCDRATGRSLGLCTTGNGFRPGLSSYPTPGLFNFLIQPGKTPLKSLISQLDDGLIVDQMLGGGSGISGDFSINIDLGYRVKNGEVQGRVKDTMLAGNVYSVLKQLVALGDDADWNGSCYTPSLIVEGLSITSKH
>NZ_AP018280.1|WP_096611516.1|5452445_5455154_+|CBS-domain-containing-protein
MPSPVLAYRFRNLWQPRRGLAIAEASVIGLVAALSAVLLKFGSGALGTWRVHSSHLFPAWIVLPLVGMVFGFLAGLLVERLAPEASGSGIPQVKATLANVPMNLSWRVACIKLLSAIIAIGSGLTLGRQGPTVQVGAGLAAGMSRWVPTSPDHRRQMIAAGAGAGLAAAFNAPIAGVLFIVEELLQDLSGLTLGTAIIASFIGGVVSRLLGGGSLLLNLQQNQISSSFAITEIPFYLLLGLCAGFLAALFNRGLIYSIKLYRRLHVSLAIRVALAGLVSGIIVSLLSNLSGDNTNLFRDNTGLREFVIATSANTSLAAIAFIVQFLLTLIAFGSGAPGGLFAPSLILGSCLGHIIGAFQENLLHAGSPTTYALAGMGAFFSGVSKVPITAIVIVFEMTTDFNLVLPLMIGSVTSYLVADKLVPGSLYDKLLKLKGINIEYKTSTEGILTKLTAREVMQSRVESLDAEMSVEEAMQAFSRSHHRGFPVVEDSRLIGIVTQTDLLKVGDNPSQEFDKSIIIKQTILRQIMTPEPVTVTPYHNLSNVLYLLDRYKISRLPVVEGKRLIGIITRADIIRTEADHLNCENPEKPPTEPSYVVYQTRSPSTGRGRLLLPIANPDTATTLIKMAVAIARERHYEIECVQIILVPRYSSPAETQVRTTKSRRLLRQTEVLGKKWQIPIHTQIRVAHDVAQAILETISDRHIDILLMGWKGSTDTPGRIFGNVVDTVVRQATCEVMLVKLGTQHIRQEGEISTNQHPALSTEDSEIQFNNWLIPMAGGPNAWLAIKLLPALVTLGNEPKIRLTRVFHPSEVKPDMKVLEDATRQIIRRRQLYTTVIAEAVKAESVSEGVINLVSKGHYDVVVLGASREGMLQQAIKGNIPEAIASGVESTVILVRGAINAE
>NZ_AP018280.1|WP_096611514.1|5455189_5456206_+|LD-carboxypeptidase
MNRRQFITTAGITTLATQFSLSTVQAEIKPQTIIKPPRLQIGDTVGLVAPAGIIEAKDIEDATKTFAELGLKVKLGKYILERYGYLAGTDIQRAHDINRMFADKSVKAIIAMRGGWGCNRILSLLNYIDIRKHPKIILGYSDITSLLLAINARSRIVTFHGAVATSTWNQFTVSYLKPILFDAGIVTMQNLNNIEAGKVEVINPGKAKGKLVGGNLSVISSMLGSPYLPGWNRRIFFAEDIGEDVYRIDRMLAQLKNAGILNQFSGFIFGQCTNCKPGDEPTFQLKQVLQDYIKPLNIPAFYGSMIGHIQDKFTLPLGVDVEIDAVSGTITMLESAVS
>NZ_AP018280.1|WP_096611512.1|5456341_5458249_+|alpha/beta-hydrolase
MQDYPFDIQKIKLEQPALVTSNIVSYLVKSNAPISVETTYKESNNTQAVDDQNKPQETDEIIKEIANFLLLHKHQAEIVIHIHGYNTGEKDFEDWTRNIYHYILNDKFISQKTILFIGYRWPSESIALKSDEDSESFLNNVGNAIQSLPIFFRTILDSSLRGIIASFTLLLIFLIPFTGTALLLNNPDFLVSLLVFVTAFFTFLFGFVFSAILLRSTVYFRDSYRAVNYGVPDLVELIRQIDNAIVEESDKSEGVTRAQKKENLSQSLATSNSRIKLSFIGHSMGAFVTTNVIRILSDVFDEKSIQTQHSPENQPSLKLGTAFSLGRLVLASPDIPIETIMPERSNVLRSSIRRFEESYLFSNQGDFILRVASTAANYLSFPANTYDRGFRLGNVVVRDYDESYDSYNLNSKLLKQKTDVPKITFGIANQNSRDGSINQNPNSAMKCICIVSDNRYKPLDELYSKNTPVTQKLAVAGLFTYFDCTNYRDVTNNNDQVKPILTRALDKEVLSFWDNLFLIFDNFFSGRNVHGGYFDGKFSQKILYRLAFLGFKDMLLSLEDEPDCQELVNKLETEISPKLIQESLQSQTVEPDAEKLTKLLSVLSQKCNNSGIKAFLAPERYQVDILGKERDRKDY
>NZ_AP018280.1|WP_096611510.1|5458330_5459221_-|UTP--glucose-1-phosphate-uridylyltransferase
MPVSKIKKAVITAAGFGTRLFPTTKVVKKELFPVIDKDGRAKPVILLIIEEAISAGIEEIAIVVQPDDKAIFKKLFKRPPSAELFEKLSPENQKFSKYLVDIGDRITVITQAQQEGYGHAVYCAKKWVDNEPFLLMLGDHIYSSKIQKSCARQILEIYQQVNHSVIGLNIVNSEMLHQVGCVTGNWQKQNSILTINQVAEKPTLDYARDNLHVESLGDDEFLSIFGLYALTPTIFDCLEVDINQNVRLKGEFQLTTCLDVLRQREKMTGYLVAGTCFDIGIPDAYLQTLNDFRHRE
>NZ_AP018280.1|WP_096611508.1|5459207_5460281_-|GHMP-kinase
MKIFVPGRLCLFGEHSDWAGCYRRQNPDLGVGYTLLSGTNQGIYASVKQHPQQLILRTTLDDGSEKICALPMEKQALLVEAKKSSFFSYAAGVAYQFLTYFQVGGLEIDNYLTDLPIQKGLSSSAAICVLVARAFNQVYDLKLTLRGEMEFAYLGEITTPSQCGRMDQGCAYGNRPIAMIFDGDRTDIIELHVPENLYFVIVDLGAGKNTQKILSQLNQCYPFPKDEIQANVQKYLGKISYQFTKAAINALQAGDAKEIGQLMRQVQAEFDRYLIPACAVELTAPVLHKLLNYEPIQDYIWGGKGVGSQGDGTAQFIVKNQESQQQVIEIIERDFPQMQCLKLIIYPSNKTSKNTSE
>NZ_AP018280.1|WP_096611506.1|5460353_5461241_+|GNAT-family-N-acetyltransferase
MQTYKFKRSFALDSTLSPRLFNLLDSAFPGLGINELAKQARKLGGVWEHVSTPFARIDDNGTLIAHIGVLEIPMRIMGADVIVGGIHAVCTHPEYRRRGYYREVMKEVLDYCDKRYDTLLLTTDQPGLYQPFGFRVIPEHSFKAKYNSLGSVNGMRSLDISDSDDVKLIHRLLETRTTVSNIVGVFSHKALFLVNECTKPLYYFPNLDTLACLEIHNQQLKLFDLVTPELNFTLQALLEQIPQAIAEVLIYFSPDCLQFAMQAVAEIFEGDSLLMVRGTFAAEHQQFTLPRSARC
>NZ_AP018280.1|WP_096611504.1|5461489_5461729_-|hypothetical-protein
MEYLSKLSVKKNTPAWINANFKIELKTIPLSIAWYKHCYIFLHLLTKKATEILLLPALPRITLYQLTCLLQHLRFALPL
>NZ_AP018280.1|WP_096611502.1|5461794_5463543_-|NAD+-synthase
MKIAIAQLNPIIGDLSGNAQKILAAAQKAATADTRLLLTPELSLCGYPPRDLLLNPSFVAAMGTTLQQLASDLPSNLAVLVGTVEEYLEAPSNGGKSLYNSMALLENGKVKQIFHKRLLPTYDVFDEHRYFEPGLEANYFTLDDIDIGVTICEDLWNDEDFWGKRSYAINPIADLAIIGVDLIINLSASPYSVGKPNFRERMLKHSVIRFQQPMIYTNQVGGNDDLVFDGNSFALNRKGELVCRARGFDVDLAFLEFDSEKRDLQPSSMIPTPANEDAEIWQALVLGVRDYAQKCRFSKAVLGLSGGIDSALVATIATAALGKENVLGILMPSPYSSDHSISDAIALSHNLGIKTQTIPIGELMKSFDTSLAGMFAGTEFGLAEENIQSRIRGNLLMAVANKFGYLLLSTGNKSEMAVGYCTLYGDMNGGLAVIADVPKTRVYSLCNWLNNRGTQGDSELGDAEKIINPIPQNIITKAPSAELKPGQVDQDSLPPYDILDDILQRLIHNHQSAAQIVAAGHESTVVARVIQLVNRAEFKRRQAPPGLKITDRAFGTGWRMPIASNWLAVENQQNNTKKHYVQ

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Crispr_ID: NZ_AP018280_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_13

5798648-5798730

Orphan

Consensus_repeat	Method
AGATTAGAAGCGCAGTGGGAGGGTGATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018280_13

>merge|NZ_AP018280|13|5798648-5798730|CRISPRCasFinder
AGATTAGAAGCGCAGTGGGAGGGTGATAAATCTGCACAGAAGGCTACTTTAGCAAGATTAGAAGCGCAGTGGGAGGGGGATAA

>NZ_AP018280|13|13|5798648-5798730|CRISPRCasFinder
AGATTAGAAGCGCAGTGGGAGGGTGATAA	ATCTGCACAGAAGGCTACTTTAGCA
AGATTAGAAGCGCAGTGGGAGGGGGATAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096613368.1\|5794256_5795048_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_AP018280.1\|WP_096611073.1\|5786659_5788213_+\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_AP018280.1\|WP_096611042.1\|5809619_5811581_-\|type-IV-secretion-protein-Rhs	unknown	unknown	gnl\|CDD\|226032
NZ_AP018280.1\|WP_096611038.1\|5812212_5814888_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611046.1\|5806466_5808971_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270284
NZ_AP018280.1\|WP_096611050.1\|5803236_5804556_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP018280.1\|WP_096611052.1\|5801708_5803145_-\|IS66-family-transposase	unknown	unknown	gnl\|CDD\|376980
NZ_AP018280.1\|WP_096611071.1\|5788209_5789208_+\|ribose-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226633
NZ_AP018280.1\|WP_096611040.1\|5811663_5812170_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096611069.1\|5789405_5791019_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|335962
NZ_AP018280.1\|WP_096611063.1\|5792075_5792930_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319
NZ_AP018280.1\|WP_096611067.1\|5791140_5791560_-\|GFA-family-protein	unknown	unknown	gnl\|CDD\|226314
NZ_AP018280.1\|WP_096611054.1\|5800942_5801665_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|274374
NZ_AP018280.1\|WP_096610996.1\|5793148_5794072_+\|IS5/IS1182-family-transposase	unknown	unknown	gnl\|CDD\|372577
NZ_AP018280.1\|WP_096611044.1\|5809062_5809458_-\|DUF4280-domain-containing-protein	unknown	unknown	gnl\|CDD\|379472
NZ_AP018280.1\|WP_096611048.1\|5804608_5806372_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_AP018280.1\|WP_096611065.1\|5791596_5791968_-\|DUF2834-domain-containing-protein	unknown	unknown	gnl\|CDD\|371414
NZ_AP018280.1\|WP_096611075.1\|5785489_5786551_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|380544
NZ_AP018280.1\|WP_096611061.1\|5797081_5797945_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP018280.1\|WP_096611056.1\|5799719_5800895_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|130253

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096613368.1\|5794256_5795048_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	2.311e-44
NZ_AP018280.1\|WP_096611073.1\|5786659_5788213_+\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_AP018280.1\|WP_096611042.1\|5809619_5811581_-\|type-IV-secretion-protein-Rhs	gnl\|CDD\|226032	COG3501, VgrG, Uncharacterized protein conserved in bacteria [Function unknown].	1.70571e-23
NZ_AP018280.1\|WP_096611046.1\|5806466_5808971_+\|hypothetical-protein	gnl\|CDD\|270284	cd13566, PBP2_phosphate, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.65913e-11
NZ_AP018280.1\|WP_096611050.1\|5803236_5804556_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.49123e-32
NZ_AP018280.1\|WP_096611052.1\|5801708_5803145_-\|IS66-family-transposase	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	1.65305e-41
NZ_AP018280.1\|WP_096611071.1\|5788209_5789208_+\|ribose-ABC-transporter-permease	gnl\|CDD\|226633	COG4158, COG4158, Predicted ABC-type sugar transport system, permease component [General function prediction only].	1.75793e-133
NZ_AP018280.1\|WP_096611069.1\|5789405_5791019_+\|hypothetical-protein	gnl\|CDD\|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	1.12177e-20
NZ_AP018280.1\|WP_096611063.1\|5792075_5792930_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.19325e-31
NZ_AP018280.1\|WP_096611067.1\|5791140_5791560_-\|GFA-family-protein	gnl\|CDD\|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	7.0693e-33
NZ_AP018280.1\|WP_096611054.1\|5800942_5801665_+\|ABC-transporter	gnl\|CDD\|274374	TIGR02982, heterocyst_DevA, ABC exporter ATP-binding subunit, DevA family. Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. Cyanobacterial examples are involved in heterocyst formation, by which some fraction of members of the colony undergo a developmental change and become capable of nitrogen fixation. The DevBCA proteins are thought export of either heterocyst-specific glycolipids or an enzyme essential for formation of the laminated layer found in heterocysts.	2.83671e-146
NZ_AP018280.1\|WP_096610996.1\|5793148_5794072_+\|IS5/IS1182-family-transposase	gnl\|CDD\|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.48747e-29
NZ_AP018280.1\|WP_096611044.1\|5809062_5809458_-\|DUF4280-domain-containing-protein	gnl\|CDD\|379472	pfam14107, DUF4280, Domain of unknown function (DUF4280). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 129 and 456 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.28392e-40
NZ_AP018280.1\|WP_096611048.1\|5804608_5806372_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	8.04629e-31
NZ_AP018280.1\|WP_096611065.1\|5791596_5791968_-\|DUF2834-domain-containing-protein	gnl\|CDD\|371414	pfam11196, DUF2834, Protein of unknown function (DUF2834). This is a bacterial family of uncharacterized proteins.	2.01849e-22
NZ_AP018280.1\|WP_096611075.1\|5785489_5786551_+\|transcriptional-regulator	gnl\|CDD\|380544	cd06321, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. This group includes the periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consist of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	2.58036e-120
NZ_AP018280.1\|WP_096611061.1\|5797081_5797945_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.08405e-16
NZ_AP018280.1\|WP_096611056.1\|5799719_5800895_+\|ABC-transporter	gnl\|CDD\|130253	TIGR01185, membrane_spanning_subunit, DevC protein. This model describes a predicted membrane subunit, DevC, of an ABC transporter known so far from two species of cyanobacteria. Some experimental data from mutational analysis suggest that this protein along with DevA and DevB encoded in the same operon may be involved in the transport/export of glycolipids. [Transport and binding proteins, Other].	1.25216e-139

>NZ_AP018280.1|WP_096611061.1|5797081_5797945_-|TetR/AcrR-family-transcriptional-regulator
MQPKKRSVEKLNIDSTRSPDKIEAILQGAMQEFLTHGFAATSMDRVTAAAGVSKTTVYSYFQDKEKLFIALIEHLITTCGDVLNQQNPEFFQGEPKEVLAGLANHFLNQLSQNVNDKPEFLDLIRLMIAESGRFPMLAQHMVRNTDKNFLQIVTQYLRSHPELQLTDPEATTRVFLGTLVHFVMVEYMLQAGEIIPMERQRLIDCLVNLITGKQTTDKKKYSAIKDKSSRRKRSISGKFERDYTEPKQLRSLRLTDTAWENLDAIAQKNNLTRTELIELFARGVKFD
>NZ_AP018280.1|WP_096613368.1|5794256_5795048_-|TVP38/TMEM64-family-protein
MINFIVSQHQNNVIADISTKNWQKLLRLATLMVMAFGIALIFTVKPAFGQEVAQNAQDFHPQTWLKNALQWVEGLGSVGALAFILLYILASVAFLPGSILTLGAGVVFGVVMGSLYVFIGATIGATVAFLIGRYLARGWVAKKIAENDKFRAIDKAVAREGIKIVLLTRLSPIFPFNLLNYAYGVTGVSLKDYVFGSIGMIPGTIMYVYIGSLAGSIATIGTESQPGNPAVQWAIRIIGFIATVAVTIYVTKVARKALEDEVL
>NZ_AP018280.1|WP_096610996.1|5793148_5794072_+|IS5/IS1182-family-transposase
MSDILNYIEEHPQETKRLIGLNYTELENLIKNAEILHNEKQVLLENKKVRLIEKGGGRQPILSTKEQVILTLVYLRHLMTFQVIGIQFGVSESTANSTFHYWLPLLRDLLPSSLLEQVKKNDTDYETVQEILTDYELIIDSYEQVRERPGHNKEQEKYYSGKACKHTFKTQMAILPNSRDIVDVVAGEPGPKHDITLFRENRDNFHPKQRFKGDLAYQGEDLIDTPIKKPKNGKLTVEQKQQNKKFSSKRVLVEHRIRSVKIFRVVQERFRLKPQKYEQVILTVCGLVRLRIKALILPNVINLSASG
>NZ_AP018280.1|WP_096611063.1|5792075_5792930_+|XRE-family-transcriptional-regulator
MKQPLTVANSNLNQSFGTLLKQWRNQRGFSQLDLAVMSQVSQRHISFLESGRAKPSREMVLQLATVLEIPLRQQNLMLTTAGFAPIHTETDIMAPEMTSIRRAIDFMLQKHEPLPAIVVDRYWNLILANNAGTRLLTTFIDADKLQRTFYVDGKINLMRVVFHSQGLRPFIVSWEDFARHLLQRLHREALAEGESELSTALLKELMSYPGVSEIWHTSNQTPNQTPQNSLLLSIHLKKNDLELQFFSTIATLGTPYDITLQELRIECLFPADEATEHNWQQLVK
>NZ_AP018280.1|WP_096611065.1|5791596_5791968_-|DUF2834-domain-containing-protein
MLQSTNISTKNSFNSIKTFYLLLAIAGSITPWFWLLQDTTALLSPALFLQRAFENNVAADITSDLLISAIAFLGFAWVELKRLGTSRLWAIVYIGLTLGIGLSCALPCFLYHREQMIEGNILR
>NZ_AP018280.1|WP_096611067.1|5791140_5791560_-|GFA-family-protein
MKIPFTGGCMCGNVRYECTAEPIVMGNCHCRDCQRATGTAFAAAMLVPLNAVTVTGDVKYFDVIGDSGSIVGRGFCPNCGSRLFSKPPMPGLMGIMAGSLDEPSEFQPGIDVYTASAQPWDCMNPDLPKFDKMPPSSNV
>NZ_AP018280.1|WP_096611069.1|5789405_5791019_+|hypothetical-protein
MLKYLLSSFPLLLLASPAVWAAPLDNSAAADMKVNTLQGQVTSVSQFSDVQPTDWAFQALQSLVERYGCIAGYPNATYRGNRALTRYEFAAGLNACLDRINELLATATSDLVKKEDLAVLQKLQTDFATELATLRGRVDNLEARTTTLEQQQFSTTTKLNAQIITAVSDTFGNQVGGTDDETNLFFATRGRLNLESSFTGKDLLRVRLEFGNFANANGSSQIAAATGTGMTRLNFDNDSNNKLFVPHVRYYFPVSDSLSFVVGSTGIGYNDITDNITPATIADDGNGIPSLFGKNSLLFERGGGGAAANWKITEDLILTLGYLANTPNNSTAKNGLFDGGYNALAHLAYYGKQGAIGVAYSHGYNPGGTVDITAGRGSALSSAPFGNSIATSNSIVGVQGYYRFSPNFQVHGWGGYIWATAKNSGLSDIANGRGGTDSLFVNSADNANACFGAIGMSFPDVGGKGNLPGILFGLPPRVSHSDVREEGDSSYHIEAFYRWRLNDNISVTPGFWMILNPENDSSNDTQYVGVVRTTFDF
>NZ_AP018280.1|WP_096611071.1|5788209_5789208_+|ribose-ABC-transporter-permease
MSQTLRPVNNRPSQNSAASRRKSINNFLQVAGILPILVIICILFSLLSPNFFTAGNAVNILRQASINIVLATGMTFVILTGGIDLSVGSILAVSAVVAVLVSLLPALGWFAVPAALLTGLLLGLLNGALITFMDVPPFIVTLGSLTALRGAAFLVANGTTVINRNINFAWVGNSYVGPVPWLVIIALLTVAVSWFVLRQTVLGVQIYAVGGNERAARLTGIKVNRVLLFVYGVSGLLAGLAGIMSASRLYSATGILGQGYELDAIAAVILGGTSFTGGIGTIGGTLLGALIIAVLNNGLTLLNMSYFWQLVVKGLVIIAAVMIDRLRRRSRR
>NZ_AP018280.1|WP_096611073.1|5786659_5788213_+|sugar-ABC-transporter-ATP-binding-protein
MTTNIKTDFSPAATATPVLEMQGIAKRFHGVAALQGVNLTIYPGEVHALMGENGAGKSTLMKILAGAYIADEGEIRINGQPVKITDPGTARKAGINLIYQELNVAPNLTVTENMFMGSELQRGQFLDRKTMELEAQEVLDSLGATFTPQTIVGTLAIAEQQQVEIARALKDKSRILVMDEPTAALSDHETERLFEVIRKLRNDGIAIIYISHRMEEIYALADRISVLRDGQYIGSLTREEISPQRLVQMMVGRSMQDFYEHQRQKSPGAVVLEVRNISDGRKVQPASFQLRAGEILGLSGLVGAGRTEVSRLIFGADRKVSGEVFLNGKKLEIHSPSDAIAAGIGYVPEDRKDQGLFLEMSSRKNIGLNRLKQDAKGGIVNWVSVNKIAADAVENFHIRLANLEIRAVDLSGGNQQKLLLARWLAINPRVLMLDEPTRGVDIGAKSEIYRIISDLSAQGVAILMVSSELPEIVGMSDRVLVMREGQLVGELDDSPGKEITQENIMHYATGASEVTAS
>NZ_AP018280.1|WP_096611075.1|5785489_5786551_+|transcriptional-regulator
MNVKKIPFTTGVAATLLSIVSGTLVSCTNISPNGDTATNTDTKNVTDTTTQSNNGDGLRPVVGDRNVKLQAVGVTLGDLSNPFFVVMAQGAEKEAKKIGGNDVRVTVVSSGYDLNQQFNQIENFVAANTDIIILNAADSKGIRPAVEQARKAGKIVIAVDTGVDADVDATVTTNNVQAGEISCQYIVDRLKGKGNVVIVNGPPVTSVIQRVDGCLKVFAKYPDIKILSKDQNAEGSRDGGLRVMSDILVTFPKIDAVFAINDPSGVGVDLAANQAKRKEFFIVGVDGAPEAIEAIASNDSLYAATATQNPRGMTQKAVQVGNDILHGKKPASPDILIPAKLITKENVSTSTGW
>NZ_AP018280.1|WP_096611056.1|5799719_5800895_+|ABC-transporter
MLKFIQELQRRTPLGWLQLKLHKGRFIVALSGIAFADILMFMQLGFQSALFDSNTRLNRDILADIVLISSQAKNTPNISTFPRSRLFDASDVPGVKAAEPMYIGMVTWKNPQTRKKVKVQAIGFNPEIPALNIPEANAQLDKIKLPDNFLFDRRARGDYSQVFAQIEAGKDVSTEIGKRTITVNGLFSFGASFAADAIILSSEDNFLRLFPQQKASSVNVGLIYIQPGYDPTQVATALKAHLQSDVKVLTRAEFAKFEEDVLRQESPIAFIFDFGVAMGFFIGVIIVYQILSTDVSSHLQEYATFKAMGYGNSYLLGVIFEEAIIIAAIGFIPGYIIPLGLYQLAASATNLPIYMTLARAIFVFVLTLIICIISGAIATQKLQSADPADMF
>NZ_AP018280.1|WP_096611054.1|5800942_5801665_+|ABC-transporter
MSNKSHFEPVISVNNLNHYFGKGQLRKQVLFNINLEIKTGEIIIMTGPSGSGKTTLLTLAGGLRSAQEGSLKVLGKELCGANDKQLTEARRGNGYIFQAHNLHGSLTALQNVRMGLEVHKTFSTTEMMTRSQEMLEFVGLGNRVNYYPDDLSGGQKQRVAIARALVGQPKIVLADEPTAALDKKSGRDVVELMQKLAKEQGCTILLVTHDNRILDIADRIIYMEDGYLRNNDAVGVMSQH
>NZ_AP018280.1|WP_096611052.1|5801708_5803145_-|IS66-family-transposase
MSQKMPAIQRDEELYQLPKEELVKIIQALRIELERLKEIVNKDSKSSSKPPSQDIIKKSEKKKSEQQDSEEGEKRKPGGQPGHEGKTRKGFGRVDRIEMLRPEKCPYCGGIHFLELADKIEKQVVAQFVANPIEIVEYQRIHQQCSHCGTVSAADWSDSIVPGQDLGLRLQALIGWLGNYAHMPYEKIRELIEELGQIDIGEGTLVATNQRVAQAIEKPVKELSDWVKSEQPNIHVDETPWTVKGVKEWLWVFANRGFCLFKAADTRSRDELESILGSEYAGVLSSDDFSVYNGYAANAQQKCLAHMRRHFKNLSKSPVLHNHEIALCFIELIDDVFKNYQQFQITGSLEAYKQWAFDFKSTINKAFKEWIPQAGATALNLLTKLRDKYDQWWYCLDHPEVPPDNNLAERNLRLAVTKRKISGGSRSLERFGDTANLLTVVQTCRSQGRSVIGFFANAILAHTHNQIIFPSLIPCSAT
>NZ_AP018280.1|WP_096611050.1|5803236_5804556_-|pentapeptide-repeat-containing-protein
MKSLLLSLIISSLLVSTAEAAKTSHILKLKETRQCAECDLEDANLKQAFLQKANLRTANLKDANLNGADLRGAFLQKADLRGADLRNAKLEDANLEGAKLDGAMLKNTVISDRTVIERKWLEVFRLVNTQVSNPDLSGVDLAGANLNGLDLRNHNLEGANLQNATLEQALLSGANFNRANLQETSFFISDLRNTSFREANLKKGSLQATDLRGANLSHTNLSRTNLSSAYLEGANVSNSNLDNANLASSILRETDLSQAQLRNANLFTADLRKADLSGVNLRGANLRGADLTQTELENGILGGTKLDGAILREMKLNGANLSRLNLSNVDFNGVNLSNANLRGTNLSGANLSQAILDGANLEGANLSGANLHKAILDSANLLEANLSKANLSEANLNKANITRANLSEANLQRTILSGIRLEFANFCGAIMPNGSKGKC
>NZ_AP018280.1|WP_096611048.1|5804608_5806372_+|tetratricopeptide-repeat-protein
MKITSIHNLQKLANIASISLIFLVANKTKSSAFILNTSTPYLIAQKGLEDDLKDPNYWSNLCNLQLQSKKYEEALTACEQAITLRPKNPILWADHSGVLLKMKKYPEAIASAERALKFDKKTSLALTYQCMAFAELGRHEEGLDNCNQALKVDGNWGKQSPKLAWLHRGVILTNLGQFDQAAIAYDRTLLLEPKDSLALAYRCELMNKIGQPQQAITNCNDALAGNGDWGEKSQTFAYANRAIAYRQQNQLQKAIADYDQLLAIDPNDAIAWTAQGIVLEQLSRFTEALTSFDRAIAINPKYSLAQVGRCGMLNRNKMYEPAQAACDEAIKGNGQWGEIGAAQAWSEIAHALSGQQQYEKALAAANRAVGIKPDYAEAWSNRSVALWQLQQYPEALASSQKAIELKPNYAQAYFNQGTILTKQEQYKAALNSYIKALSLDPKNPKGWANISVVLWHLKQYQPALTAADRAIAIKRDSFEAWYNRGLVLTSLSRHKDALKSYNSAIKINPKSADAFTGRGIILSKLKYYPQAIAALQEALKLNPQQVVAKATLKVVMKEQASQIEEKGKKQGEKGKGERGKCGEREKC
>NZ_AP018280.1|WP_096611046.1|5806466_5808971_+|hypothetical-protein
MKIQKVPQVILKPFVKNYLNQYSRILKHTKYNALMRWSWMQPILEELKGELFADETETVAETAKIITPPPDLPREAGVQFFDSPYQRYACICNDPLRCDRALPITQTGDKTQACTSCGFPALLAEPVLIPNLPEPKQQKIAGLRGVYRIERWLGRLGMGRIYAATQLGINQPVIIKEYLLPGRYFNAEEIHKQLQLFKSVAGICLADGRVQDFRFLQPIEAIIDELQGRCYLVMDERYACPTLNNYLANYRGRKEREKGEGEIRVRGNKENKKNQGMSSSQVHLVLNQTLQTLEFLHGQKFRFPSAQIQNGVVHGNINLDSLLMVKSNQNGYEQSLKVIDEDTIIGSLIVEDLDFFIYLCDLAIWERIFIPISETSVKNNFKDKLENADKPQDLISLGYIAFYLLLGKVISDAGYALDPENETHWGNINPHLKKFIRRLIKGEFLSAEVARQELLKLPKAAFEVPIELSAEAETETPTKFPRLLIFLLTTLGLGVVGGLAWLFFAKPQLSNANSNTPQLNLIKEVGAIPTGNFTYTASKNGIWDYIIQQPDLIQKGQTLEQRLTIAQPKLQLNYQPTTSTEEAIAQVQSGKSAFAIVPLIQPLPADLQAQPIAYDGIGVFVAFSYSQRQKGLPEKLNGQITVEKLRQLYAGNISNWQELGGPNLAVNIYAPVDQEVRQVFTQQILKAKNSPIKSKEDSLQTSQELQEFEMMRTVLRDFESQQAGGIGFGSLSKIVGQCSVYPLALQIEGQPPIQPVILSNNQSIEPNTDLCDRKGSYHPNSELFRTGRYPGAYAIAVVYPIDNNRPPIGEKFAQLLKTKEGQRLLKLTGLVPLE
>NZ_AP018280.1|WP_096611044.1|5809062_5809458_-|DUF4280-domain-containing-protein
MPQQVVMGATLQCVPFGVAPSSLIVIPKGSPVLASGMLAATVMDFAPIANIPPFGMCNSLANPTVAAATAAALGVLTPMPCLPVILGPWKPGAIKTQINKMPALPSTAICNCAWGGVIKIAFPGQIKVSVN
>NZ_AP018280.1|WP_096611042.1|5809619_5811581_-|type-IV-secretion-protein-Rhs
MPASYTATPILKIDGKDASANLLDDILQISVEESLHLPGMFTLMIRNDYYGSRSGENPWMHDNTFAIGKSIEIGFVSSTTADSSFSTPGKSTLIKGEITAIEAQFNSESQAPILVRGYDISHRLHRGRYNRSFQNMTDTDIVKNIIGEVGITAGTIDNTGGPYGFGDPVGYTFQENQTNMEFLRERAARNGFELFVQDGKLYFRKPVAGGSLSLKWLKDITHFHVRVSSAEQVSAVQVRGWDYQKKEAIVSNQTSQNAQVVTSINQGKGEDSIHEFNKNPTMIVVDRPISSQKESDAIAQSIFNELSGEFVQADAKAEGNPAIRPGKVVTLQDMGKYSGKYYITETRHLFQARVYSTEFSVRGLREDSLANFISPQARLQPGQTLMIGIVSNNKDPKKWGRVKVKFPTLTDKHESDWARVVSVGAGNNRGFDCLPEVNDEVLVGFEHGDIHRPFVIGGVWNGKDAPPATVDDAVVDGKVRLRTLKTRTGHTLQFVEEDKGDSKKGVYLNTVYGHKLHLNDSDKLIDIKTKDNYQVTLDDQNKKILIKTNTGYICELNDQSQKITLKASSQEIVMKASGQIDINAQQNITLKVGGNKIEISPTNIKLTAGTSSIDLSPSGATVKSSAMTQVEGSMTTIKGNGTVTVSAPMVSIG
>NZ_AP018280.1|WP_096611040.1|5811663_5812170_-|hypothetical-protein
MSLTKAKLVSSDGGGTIEFMFNPTQLKFSQRISLNKNEGARTGRGLPKVNFAHPQPCTLSIGDIILDTYEEGSNKSVLPYIKQFEKAVNFLEQGSEKDKRPPTYVFTWGNYQYIRCFVTDLAYTLTMFLPDGTPVRAKLDLTLEEIDESTSQPGMSTPSNPDRLGGGR
>NZ_AP018280.1|WP_096611038.1|5812212_5814888_-|hypothetical-protein
MAESNNLPVTNNSNFEESFSAEPLGIKNTLLPSQTLGEKGINPQFLVPLGVQSISVLDTNLLSPKYIEYDFSSSLFEDSPFFSEYINQSQVDTDSQINSSLALAPQFQGQSIQAKSEISYSSEKISSSENVTQSAENQIQPSLINQDITDSPQIKLKQYSTEDVVRSHFNQTAENPVQPSLINPNITDSPHIQLKQDSTENVVRAHFNQTTENQVQASSINPDINDSPQIQLKQDSTEPVVRSQFNQTTENQVQTSSINTEITDSPQIQLKQDSTEDFVRSHFNQTIENQVQTSSINPDINDSPQIQLKQDSTENVVHSGFNQTPENQIQASSINSDITDYVQKKLNKIAENLIQPSLINTEITDSPHIQLKQDSTENVVRSHFSQTPENQIQPPSINPDIIDYPEIQFKQDSTEDVKRSHFNQTAENQVQASSINTEITDSPQIQLNQDVTENVVRSQFNQTIENRIQPSLINTEITDSPHIQLKQDSTENVVRAHFNQTTENQVQASSINPDINDSPQIQLKQDLTENVVRAHFNQTTENQVQASSINPDINDSPQIQLKQDLTENVERSHFNQTAESPVQTSLINTDITDSPQIQLKQDSTANFERSHFNQTPENQVQTSSINPDVTIFPEIQLKQDSTELFVRSHFNQTIENQVQTSSINPDITDSPQIQLKQDSTELFVRSHFNQTLENQVQPSSINTDINSKESNIHPYEINDLPQVLQKITILDPITPRKSINESQQNIDVMTTNINRKTSNINNQISALQPKLEATQIFSSISNKNSSSNSSQWSDFNSLVRGQTTPSKRRSNSTSDNNPTNTSIQAKMSDNLEPIRISRKQDFHSENENSISDNVSKNELEIVAQAIYQQLKQRIRVEFERHGQGYLGRLPW

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Crispr_ID: NZ_AP018280_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018280_14

5991600-5991926

Unclear

III-A

Consensus_repeat	Method
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	PILER-CR
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAAC	CRISPRCasFinder
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	CRT

4 spacers

cas6

The CRISPR arrays of NZ_AP018280_14

>merge|NZ_AP018280|14|5991600-5991926|PILER-CR,CRISPRCasFinder,CRT
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACGAATGACACGGTTTTTTGAAATGTATATACAATAACTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACGTCAGATATGATTATATCCCCAACGTTCCAATCTGCTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACTCAAATTGGAAATGCGGCAAAAAAGTACCATCTTCACTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACGAAATAGCATAAAAAGAACTGAATTTAAAACTTAGCTTGAAATTACCTTTTACCCCGCAAGGGGATTAAAACG

>NZ_AP018280|14|6|5991600-5991926|PILER-CR
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	AATGACACGGTTTTTTGAAATGTATATACAATAA
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	TCAGATATGATTATATCCCCAACGTTCCAATCTG
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACT	CAAATTGGAAATGCGGCAAAAAAGTACCATCTTCA
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	AAATAGCATAAAAAGAACTGAATTTAAAACTTAG
CTTGAAATTACCTTTTACCCCGCAAGGGGATTAAAACG

>NZ_AP018280|14|14|5991600-5991925|CRISPRCasFinder
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAAC	GAATGACACGGTTTTTTGAAATGTATATACAATAA
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAAC	GTCAGATATGATTATATCCCCAACGTTCCAATCTG
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAAC	TCAAATTGGAAATGCGGCAAAAAAGTACCATCTTCA
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAAC	GAAATAGCATAAAAAGAACTGAATTTAAAACTTAG
CTTGAAATTACCTTTTACCCCGCAAGGGGATTAAAAC

>NZ_AP018280|14|6|5991600-5991926|CRT
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	AATGACACGGTTTTTTGAAATGTATATACAATAA
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	TCAGATATGATTATATCCCCAACGTTCCAATCTG
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACT	CAAATTGGAAATGCGGCAAAAAAGTACCATCTTCA
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	AAATAGCATAAAAAGAACTGAATTTAAAACTTAG
CTTGAAATTACCTTTTACCCCGCAAGGGGATTAAAACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018280.1\|WP_096610798.1\|5992055_5992736_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_AP018280.1\|WP_096610792.1\|5995485_5995731_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|226603
NZ_AP018280.1\|WP_096610796.1\|5992937_5994563_-\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_AP018280.1\|WP_096610794.1\|5994734_5995178_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096610806.1\|5985307_5986360_-\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380527
NZ_AP018280.1\|WP_096610780.1\|6002449_6003469_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP018280.1\|WP_096610802.1\|5988895_5989147_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|379097
NZ_AP018280.1\|WP_096610808.1\|5983506_5985003_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226364
NZ_AP018280.1\|WP_096610816.1\|5978181_5979372_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_AP018280.1\|WP_096610782.1\|6001369_6002281_-\|transporter	unknown	unknown	gnl\|CDD\|130314
NZ_AP018280.1\|WP_096610814.1\|5979499_5980897_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|227328
NZ_AP018280.1\|WP_096610786.1\|5997373_6000037_-\|OLD-family-endonuclease	unknown	unknown	gnl\|CDD\|226121
NZ_AP018280.1\|WP_096610804.1\|5986516_5988616_-\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_AP018280.1\|WP_096610788.1\|5996482_5996947_-\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119345
NZ_AP018280.1\|WP_096610810.1\|5982449_5983493_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226962
NZ_AP018280.1\|WP_096610784.1\|6000937_6001300_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018280.1\|WP_096610812.1\|5981444_5982380_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224005
NZ_AP018280.1\|WP_096610790.1\|5995727_5996126_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NZ_AP018280.1\|WP_096610800.1\|5990184_5991321_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NZ_AP018280.1\|WP_096610818.1\|5976945_5978130_-\|DUF1822-domain-containing-protein	unknown	unknown	gnl\|CDD\|370155

Protein	Function_ID	Function_description	E-value
NZ_AP018280.1\|WP_096610798.1\|5992055_5992736_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	2.91501e-54
NZ_AP018280.1\|WP_096610792.1\|5995485_5995731_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	1.98731e-18
NZ_AP018280.1\|WP_096610796.1\|5992937_5994563_-\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	3.38116e-72
NZ_AP018280.1\|WP_096610806.1\|5985307_5986360_-\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380527	cd06304, PBP1_BmpA_Med_PnrA-like, periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. These outer membrane proteins include Med, a cell-surface localized protein regulating the competence transcription factor gene comK in Bacillus subtilis, and PnrA, a periplasmic purine nucleoside binding protein of an ATP-binding cassette (ABC) transport system in Treponema pallidum. All contain the type 1 periplasmic sugar-binding protein-like fold.	4.08058e-103
NZ_AP018280.1\|WP_096610802.1\|5988895_5989147_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|379097	pfam13275, S4_2, S4 domain. The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	1.82561e-28
NZ_AP018280.1\|WP_096610808.1\|5983506_5985003_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226364	COG3845, COG3845, ABC-type uncharacterized transport systems, ATPase components [General function prediction only].	0
NZ_AP018280.1\|WP_096610816.1\|5978181_5979372_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	8.29159e-10
NZ_AP018280.1\|WP_096610782.1\|6001369_6002281_-\|transporter	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	2.41586e-26
NZ_AP018280.1\|WP_096610814.1\|5979499_5980897_-\|CHAT-domain-containing-protein	gnl\|CDD\|227328	COG4995, COG4995, Uncharacterized protein conserved in bacteria [Function unknown].	2.04129e-102
NZ_AP018280.1\|WP_096610786.1\|5997373_6000037_-\|OLD-family-endonuclease	gnl\|CDD\|226121	COG3593, COG3593, Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair].	8.84072e-12
NZ_AP018280.1\|WP_096610804.1\|5986516_5988616_-\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_AP018280.1\|WP_096610788.1\|5996482_5996947_-\|ASCH-domain-containing-protein	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	1.50866e-62
NZ_AP018280.1\|WP_096610810.1\|5982449_5983493_-\|ABC-transporter-permease	gnl\|CDD\|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.38175e-107
NZ_AP018280.1\|WP_096610780.1\|6002449_6003469_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.09839e-106
NZ_AP018280.1\|WP_096610812.1\|5981444_5982380_-\|ABC-transporter-permease	gnl\|CDD\|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	1.05795e-105
NZ_AP018280.1\|WP_096610790.1\|5995727_5996126_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.83816e-59
NZ_AP018280.1\|WP_096610800.1\|5990184_5991321_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.447e-36
NZ_AP018280.1\|WP_096610818.1\|5976945_5978130_-\|DUF1822-domain-containing-protein	gnl\|CDD\|370155	pfam08852, DUF1822, Protein of unknown function (DUF1822). This family of proteins are functionally uncharacterized.	9.80735e-87

>NZ_AP018280.1|WP_096610800.1|5990184_5991321_+|CRISPR-associated-endoribonuclease-Cas6
MPRSPTPKKKPTTTRTRSKSSLSWADDSEIIGLEFELFTPVNASIYPQYSIGLHAWFLNCVRAVDPDLSAYLHDGESEKPFTISLLDGEIVSSGMNIQLSSDRIYRWYVTGLSSRVTRWMQNWVDNLPTHIELSNIPLKIQSCRIAYPATTYSQLLNKENIGGSVCLNFLSPTSFRRKKHHFPLPVPFNLFQSYLRRWHDFSNFPVETNDFLAWIDEQVIINSHQIASQKVLAGKKGAVTGFTGSIELSLARTAIQNPEYYRLFYALTNFAPYCGTGHKTTFGLGQTRLGWSSKQVQHVPDVASVIATRIEDLTEIFTNQRKRQGGERASEIATKWATILARREMGDSLIAISQDMGIPYETAKTYVKLARKALKEES
>NZ_AP018280.1|WP_096610802.1|5988895_5989147_+|RNA-binding-S4-domain-containing-protein
MKPRDNTIKLNQFLKLMGIVPTGGQAKLMIQGGEVLVNGVLETRRGRKLVPGDKVTLEGQTFEVNLNNNQDSNTFLNSSQENE
>NZ_AP018280.1|WP_096610804.1|5986516_5988616_-|hydantoinase/oxoprolinase-family-protein
MLKVFADRGGTFTDIVAVTDSQLIIDRLLKHPQRFLIVSLGDRQWVIVYKLLSENPEQYQDAAIQGIRDILGLTSNQPIPTTEIEVVKMGTTVATNALLERKGDRVVLVITKGFKDALRIGYQNRPNIFARQIILPTMLYEQVVEVDERYDAQGNELIPVNIEQVKKDLEAAYNLGIRSCAIIFMHSYNYPQHEEIVAEIAQQVGFSQISISHQVSPLMKLVSRGDTTVVDAYLTPILQRYINQVANQLPDVKLMFMKSDGGLVAAAQFQGKDSILSGPAGGIVGAVQTSKRAGFELVITFDMGGTSTDVAHFKGEYERQLDSEIAGARMRVPVLDIHTIAAGGGSILFFDGSSYRVGPESAGSNPGPASYRRGGKLAVTDANIMLGKIHPQYFPSVFGIDGNLPLDKEVVNEQFQQLATGNSRTPEEVAAGFIAIAVENMANAIKKISLQRGYDVTEYVLCCFGGAGAQVACLIADTLGMRNIFLHPYAGVLSAYGMGLADVRTMRELGVEKELTKELIPQLQQLIQGLEIQVRNGEDIDIDLPEEIRKTREELVKKVNLKYEGSNSTLTVDFSVDILTMQQEFTELHKNRYGFIQSEKSLIVESISVEFIQKMDTPEEPLLSRMRPVDEMPIPVEIVKIFTANKWHEAPVYQREDLQPGDKIKGSAIIVEKISTIVVEPNWEARLTHHNHLILERID
>NZ_AP018280.1|WP_096610806.1|5985307_5986360_-|BMP-family-ABC-transporter-substrate-binding-protein
MAGNFGRRKFIVYASSAVGGSLLLKGCTNNQTTPANTSSNNNFKIAIALPGVISDKAWNQSGYEGIQLAKQKLGVEIAHVEKVAQPDQAEVLSDFARRGYNLVFAHGGQFDAAIQQIASQFPNTFFVGVNGNVSGANIASLRLEHLQASYLCGIIAAGMTKSNKLAYIAGQEFQATQEELRGFELGAKSIKKDIQVNSTFTGDWNDVAKAKEATLALISTGVDVIYQWLDSASATVLQTAGDKNIYAFGNTIDQLEIAPKSVLTSAVKHLDAAILYLTDLAKQKQIQGKIYKLGLERADILALGKFNQLIPAAIQKQVLTSKEEIIAKKVIFEDCKDAGKDTFCIKKNTV
>NZ_AP018280.1|WP_096610808.1|5983506_5985003_-|ABC-transporter-ATP-binding-protein
MSYLRLENITKKFGDFIANDNINLNIETGTTHAILGENGAGKSTLMNIISGLYQPDSGQIFIDDIPVKITSPAIGIQLGIGMIHQHFMLVPELTVTENIILGTGNNLHLNLDNKQAEIAQLSQSYNLEIDPSAKVKNLPVGMQQRVEILKVLYRQAKLLILDEPTAVLTPPEVRSLINILRQLAAKGHTIIFISHKLAEVMNLCDRITVLRRGKVVANTTKESATPQQLADLMISRTVNLQVNKKSTSPGAVVLSVQNLQVADDRGVIAVKNISFELHQGEILGVAGVDGNGQRELADAICGLRKVKQGKIYPSPNPSPLFVKTKSLRVGYIPEDRQKNGLVMEFDISQNLILKLFKNLPFSRYGLLRRKAINHHAISTITEFDIRANGVNILTKQLSGGNQQKIILARELAGEPELIVAMQPTRGLDVGATEAVQQRLLTEKQRGTAIVYISTELEEIMTMCDRIAVIYQGEFVGIFDASMATSEEIGLLMSGAKIS
>NZ_AP018280.1|WP_096610810.1|5982449_5983493_-|ABC-transporter-permease
MTTTIRKLVIPIISPLIAIFSALLVGAILMMIAGANPIIAYTALFQESLLSYFGFGNTLTKMTPLLFTSLGVLIALKAGQYNIGGEGQIYLGALGSTLIGLYLKNLPPFIHIPLALCAGFIFGGIWGLIPGYLKAIRGVNEVITTLLLNYIAIHLISYLVQNPLKELNAPSPYSPLIAKSAQLPIILSGSLVHAGILISTIAAVILWIIINHSTLGYQIKAVGFNPNASRYAGISVQMIIIQVMTFAGGLAGLAGSCEVMGLKYRLFDVVSPGYGFDAIAIAFLSRGNVIGVVLASLFFGALRSGANVMQRSAGVPVTVVYAIQGLTVLFIAISLALEYQVKKESPI
>NZ_AP018280.1|WP_096610812.1|5981444_5982380_-|ABC-transporter-permease
MNIAFLSDYFASTIHLTIPLAYAALGGLYSERSGILNIALEGMLITGAFTSAAATFYTGNIWIGLIATLIAGALIGLLHAFLCVTLRVNQLVSGLAINLVAAGVTAFLGRLVFANNSTQRLPNLSAIKIPIFANIPIIGNLLFQQDILVYLLFIIIALTTYFLFYTNPGLNLRAVGEYPQAADTAGVSVVKIRYMAVIFGGCLASLGGAYLTLVQVRYFTEEMSAGKGFIAIASLIFGKWHPIYSSLACLLFAATEALQLRIQALGINIPYQFLMMLPYITALLALIGLAGKSTPPAALGISYGSRKQNLR
>NZ_AP018280.1|WP_096610814.1|5979499_5980897_-|CHAT-domain-containing-protein
MNKTKLTLLAFSALSLSIIGLYGLKISRESLNSFNAVSPATKSITLPASRLQPEVLTKLLDNKDINSAIIHVEQGWKQQYDEYAQGKLPSNRMIEVREISRILEQIHQQNGTKSALIYAVPTPKHLELILVTPGKSPIHKRITKAKRDIVVSLVSKFRKDIVNPNSQRSDYLSSGKQVYDLLISPLESELQAQGINNLIFCLGGGLRTVPLAAISDGKQFLVEKYSLGIIPAFNLLDLQPANITQTQVLAMGASEFKNKEPLPAVPLELSSITSNKWQGKSLLNKEFTLQNLKKQRALYPFGIVHLATHAEFSPGSVQQSYIQFWDAQVRLDEIKSLGLDEPLVKLLVLSACRTALGDAKAELGFAGFAVMSRAQAVIASLWSVDDGGTLALMTQFYQQLKANPMKAEALRQTQIAMLKQQVSLKNNPALRGNNSLPAEVVANLDNRELSHPYYWAGFTLIGNPW
>NZ_AP018280.1|WP_096610816.1|5978181_5979372_-|sigma-70-family-RNA-polymerase-sigma-factor
MRARQNLVELFSTFLQFESNRFSGWVTDAKLYRSIKACLNNFSEAKVNEDFWAVYWHKQTQKSEKPEVALGHMSAYLQEPCYWTVQKMMLRSQQSYDKMPDLFQVAIASVPKILKSCNPDVSGSVKAYASIAFGNIIRDYLKQTKEANFCNNWALLLKTSRKLLTESLQNAGFDAATRERYLLAWTCFESIYLPRKDTRLRQTAAPDSETWQAIAAAYNHMRHQLASPGGECSKENMERWLIECGNQVRKYLYPPVKSLNAPKPGYEEGELQDELVDNFQESLLTEWIQEEEKAARLEQKKQINNILTEAIAKLDATSQQLLQLYYQKTLTQQQIAQELAIQQYTVSRRLSKTRESLLLTLTRWSQQTLHISVTSDVVKYISTVLEEWLQAHYHRE
>NZ_AP018280.1|WP_096610818.1|5976945_5978130_-|DUF1822-domain-containing-protein
MTFLTENLTQLEFQISPDLAQQSWLKSQLQSTAKGQWNAYLNQISLQILLPWLQTEYEQQTSLVFNEKLLSSFWDVVNGTAINWGHKRLIIIPEKSLDNSEYSIPQEWIDVPKLVGDYYLAVQINPDELSMRVWGYTTHEQIKVSGRYNSTDRTYSLDTEEIITDLNVLWVVSQLNPEEKTCAPVASLSPVPAIQAENLLSRLTNPNIIQPRLELPFALWGDLVSNDDWRQKLYQLRQGEVSTNLSPRQVAANISQWLQNTFEESWQSLDNLLGTNASLGFSFRKAAEESDATIKRAKSLNLPNAEVILIMGLDTETDDRIGIRIQLRSRSQEEYLPAAINLKLLSASGNIIQSIQSRSQDNIIQLKRFKSPVGTQFSVQVEVDNFVVTENFTI
>NZ_AP018280.1|WP_096610798.1|5992055_5992736_+|TrkA-family-potassium-uptake-protein
MYVLIGGVGRMGSDLAKTLIHMGHTIAAVDTDAVACQYAREKIGVMAFEGSAVNTTVLLEAGIRKANAVIATLQEDALNLALVTLCKHYGVPQIIVRMSDRDFAEPYQLAGATHIISTTELAINRVINAIEYPQVDAMMHFEQGQIEVLKLSIPQKCSIVGRSVAEIAQDYRFPAGTLIIGYQAHPQENLNIPNGSTILESGSTILAVTKPELVRQLIDFMGLCSP
>NZ_AP018280.1|WP_096610796.1|5992937_5994563_-|sodium:proton-antiporter
MVMNYLPTSEVSNLLLWQSVALPSGEFQGLVNTLIVLLLVATAVALVTRWLRIPYVIGLVLAGLAITKQALSESVGLNPDVILNLFLPILIFEAAINTDISRLRSTIKPIALLAGPGVILSAAITAILLKLGLGLVWITACAVSVILTITDTVSVIAAFRTVPVPGRLATIVEGESLFNDGVAMVLLSIITAVHLQGSFTLGEGIKQVFIAFVGGGVLGLGLGYLCVGLFQQLDDALSSILLTVAVSLGTFQIGQALGVSSAIAVLVAGLVIGNLAFRQSSASIKVTLLSFWEYAGFGVNTFIFLFVGIEVEPNILWATIPSALVAILAYQIGRIFSIYPLLFLLGFVDRPLPIRWQHVLIFGNVKGSLSMALALSLPFSLPGRMQVITLVFSTVLVSLVGQGLSLPWLVKRLQLSKPSSVRQEIEPLQLNLIAAKAAQEELKNLLQSGSLPKFLYEELFASYQARIASSEEKLRNLYNHRIDYELNELEERGYLDGLYRRLYTAEKGAINDAVLKGLLPDEIAKSYVEELNEKLLSLKDD
>NZ_AP018280.1|WP_096610794.1|5994734_5995178_-|hypothetical-protein
MELLFKISFLILSALFAGIVLFLSTVLRETFNALTEERYYSVYSEIIIRGRKSIIINIIVLVPILIFAVYLICGFRNLLFIIGSLLYIFGSFVSSILINEPAYTQLLNMDINDQAGIIRIRGLLNKGNIVRAISSFLGILLVGISIY
>NZ_AP018280.1|WP_096610792.1|5995485_5995731_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
METVNIHQAKTNLSRLLSRVELGEEIVISNRGVPIAKLVPFRTSLDRRSSLGQDRGMFTVPDDFNAPLPEDILVAFEGGAE
>NZ_AP018280.1|WP_096610790.1|5995727_5996126_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MRLLLDTQCWLWWFAQPEKLSENVIEQIADETNEVWLSVASVWEMGIKVSIGKLPLREPINDYVSTRMNQLGARSLEITASHALRVAVLPLHHRDPFDRMLIAQAQVEDMTLVSADLIFKQYEVSLLWAASS
>NZ_AP018280.1|WP_096610788.1|5996482_5996947_-|ASCH-domain-containing-protein
MSQEQLEQYWQAYLASIPNASFSSEDYEADQFGDNSVLANELGNLILRGVKTATCSALWEWEAEGSEIPKVGSKTIVLDGDNNPLCIIETIEVEIRAFSEVDTQFAFEEGEDDRSLESWRREHWEYFSRVLPKIGKQPSREMLLVCERFRVVYK
>NZ_AP018280.1|WP_096610786.1|5997373_6000037_-|OLD-family-endonuclease
MHLKTVFIRFYKSFNDDFLRKNDDRVKPKPWEMVGNTFYPYIEVPIDPKITTVVGANESGKSHLLSAIEKAISGEEIQRSDFCRYSPFFTVRQNELKYPDFGSEWSTPSKTEEGKLRMIAGIPENVRFDRFLIFRKNISELTVYLPEKGDYRPYRIDQTKADDLQDLLPVPLKIESNIALPASVPIKKLAQLGKRIDPNGRKFEVLDRKQRVNIIDALDDFSDHPELFTKVRQPWGEMEPDAVNTIKSIISALEEASFSNAEKEKREKEFELAYKLICNIAQVDVDALVDLADAVKDGMQGYANGIIEKINRQLSINLNFPNYWVQDRNFCLKVMARDYDLVFTITDRTGTEYSFDERSVGLKYFLSYYIQYRSHEPHPHKSEILLMDEPDAYLSSQAQQDLLKIFDLFAYPEPGSHLTRSIQVVYVTHSPFLIDKNHAERIRVLQKGNEDEGTRVVKDAAKNHYEPLRSSIGAYVGETTFIGNCNLMVEGLTDQILIAGATSYLRSIGTANLETLDLNRITIVPSGSASHIPYLVYLARGRDVEQPAVIVLLDSDNSGDDARKQLLGKGGQHRRPLLKEQFILQVGDLKDQFRLIETMTTKLEMEDILPLPICIQATKLYLQEFLQVEETELSFLTEDLVLSNATDQTMLNAIQISLSKFPDKNLVVNKVGFARNVLCVVQQWSQQRKSLQKAESEALQTFEDNFRVLFRQLNGMQRRAQQKLTHEKLSQKIERLKKNFVALHPVSARREDAVILLDEIEGILESNIENEAVKEIEAIKSAIQNLKRDYQLDVDMNNAIHDYIGFQMGLERVKYAGLLASQEETVEIAQVEEAITVADEDAQANKSVDAQIITSTKTLNNASEANTTKITNNPTASDKRKKHNQRS
>NZ_AP018280.1|WP_096610784.1|6000937_6001300_-|hypothetical-protein
MKIRSLGLAIAFGLGLAAVAVPQKSMAQFTNPQNYDQPNANDPFSPGVEQNGFSMFQLLHNAQLGIGSYNPDFANQKRQELDQEAASFFTRQRQRMQQGNVQPNNQSGSPVIKLEPSSGQ
>NZ_AP018280.1|WP_096610782.1|6001369_6002281_-|transporter
MSNTLTPPKSDPKSDINWQQIASPQLYQDAAPANFLGETIQETLALTKRLFIQLQRRPSTLFAGIIQPVMWLVLFGALFQNAPKGIFGSTTNYGQFLAAGVIVFTAFAGALNAGLPIMFDREFGFLNRLLVAPLASRFSIVFASAIFIISQSLLQAAVIVGAAAFLGAGLPDVAGLATIALIVFALALGVTALSLGLAFTLPGHIELIAVIFVSTLPMLFASTALAPLSFMPNWLQVIATINPLSYAIEPIRYLYTHSNWGLNSIVMRSFWGDVSFGGALLVLVGFAAVALISIQPRLRKTLS
>NZ_AP018280.1|WP_096610780.1|6002449_6003469_-|ABC-transporter-ATP-binding-protein
MAAAVSIQNLKKRYGTVEAVKDVSFEIEPGEIFGLLGPNGAGKTTTLRALCTLTTPDAGKVEVSGISVVENPKAARQRLGYVAQEVALDKILTGREMLQLQAALYHLPAAVTKQRINTVIELLGLQEYADKKTGTYSGGIRKRLDLAAGLLHAPDVLVLDEPTVGLDIESRFIVWEFLRKLREAGTTVLITSHYLEEVDALADRVAIIDRGVVIAAGTPSELKDRVGGDRVTLRIREFSPPEEAEKAKDLLKSLSFVQEVIINSAQGNSLNLVVTPQNDTLITIQQALNNAGLPMFGIAQSRPSLDDVYLAATGRTLMDAEMAAVANRDPKAEKKQNMR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP018280_11	11.1\|5385438\|41\|NZ_AP018280\|CRISPRCasFinder	5385438-5385478	41	NZ_AP018274.1	1850439-1850479	0	1.0

1. spacer 11.1|5385438|41|NZ_AP018280|CRISPRCasFinder matches to position: 1850439-1850479, mismatch: 0, identity: 1.0

ggaaattatttttaccaaaattggggttgggaatctgctgg	CRISPR spacer
ggaaattatttttaccaaaattggggttgggaatctgctgg	Protospacer
*****************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	LR214964	Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10	16633-16664	6	0.812
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	MN693026	Marine virus AFVG_117M72, complete genome	62645-62676	6	0.812
NZ_AP018280_14	14.4\|5991855\|34\|NZ_AP018280\|PILER-CR,CRT	5991855-5991888	34	NZ_LR214952	Mycoplasma neurolyticum strain NCTC10166 plasmid 2	17500-17533	6	0.824
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024793	Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence	178850-178881	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024793	Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence	335141-335172	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024793	Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence	441629-441660	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	27310-27341	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	27317-27348	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	27324-27355	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	27331-27362	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	28995-29026	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	29878-29909	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	29885-29916	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	30382-30413	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	30389-30420	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	31851-31882	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	31858-31889	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	31865-31896	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	31872-31903	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	32003-32034	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	32010-32041	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	33600-33631	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	33607-33638	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	33614-33645	7	0.781
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	MH884509	Bacillus phage vB_BboS-125, complete genome	3701-3732	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	MH319754	Marine virus AG-345-L05 Ga0172272_11 genomic sequence	92607-92638	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP004877	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB431, complete sequence	135885-135916	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP031069	Bacillus sp. JAS24-2 plasmid pl626, complete sequence	323487-323518	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011350	Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence	120180-120211	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP022446	Bacillus cereus C1L plasmid pC1L1, complete sequence	81646-81677	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP044979	Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence	236882-236913	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP007616	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB400, complete sequence	222744-222775	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP004860	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB422, complete sequence	155679-155710	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP007513	Bacillus bombysepticus plasmid pBb, complete genome	388879-388910	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	CP046512	Bacillus cereus strain JHU plasmid p1, complete sequence	179618-179649	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP042875	Bacillus cereus strain 09 plasmid unnamed1, complete sequence	11971-12002	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011154	Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence	15292-15323	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011152	Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence	531592-531623	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	114924-114955	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NC_020385	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence	104634-104665	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP050184	Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence	148673-148704	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP021062	Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence	330224-330255	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP014284	Bacillus thuringiensis strain Bt185 plasmid pBT1850294, complete sequence	91811-91842	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	826957-826988	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP032609	Bacillus thuringiensis strain QZL38 plasmid p.2, complete sequence	183712-183743	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP023312	Vibrio anguillarum strain VIB12 isolate Sea bass plasmid p292, complete sequence	252343-252374	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	AY082070	Bacteriophage phi3626, complete genome	8740-8771	7	0.781
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NC_003524	Clostridium phage phi3626, complete genome	8740-8771	7	0.781
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	LR214964	Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10	16633-16665	7	0.788
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	JN638751	Bacillus phage G, complete genome	479273-479305	8	0.758
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	31844-31875	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	MN694459	Marine virus AFVG_250M532, complete genome	15818-15849	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	76465-76496	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	49794-49825	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	202889-202920	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP013700	Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence	125928-125959	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	AP014182	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S41-C49, * SEQUENCING IN PROGRESS *	5746-5777	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	AP014181	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S40-C70, * SEQUENCING IN PROGRESS *	8175-8206	8	0.75
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	AP014183	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S42-C67, * SEQUENCING IN PROGRESS *	30512-30543	8	0.75
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	MH319754	Marine virus AG-345-L05 Ga0172272_11 genomic sequence	92606-92638	8	0.758
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	MN694459	Marine virus AFVG_250M532, complete genome	15818-15850	8	0.758
NZ_AP018280_2	2.1\|2568505\|34\|NZ_AP018280\|CRT	2568505-2568538	34	NZ_AP018256	Calothrix sp. NIES-4071 plasmid plasmid1 DNA, complete genome	78884-78917	9	0.735
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	NZ_CP054145	Deefgea sp. D17 plasmid unnamed2, complete sequence	14449-14481	9	0.727
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	JN638751	Bacillus phage G, complete genome	479273-479306	9	0.735
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024793	Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence	200657-200688	9	0.719
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024793	Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence	517203-517234	9	0.719
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024793	Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence	699722-699753	9	0.719
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP051207	Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence	29871-29902	9	0.719
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP024791	Nostoc flagelliforme CCNUN1 plasmid pNFSY06, complete sequence	161780-161811	9	0.719
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	AP017993	Planktothrix agardhii NIES-204 plasmid plasmid2 DNA, complete sequence	78579-78610	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	MT782071	Escherichia phage JN02, complete genome	29315-29346	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	KY703222	Escherichia phage phiC120, complete genome	118061-118092	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	MN693034	Marine virus AFVG_117M74, complete genome	881-912	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP017256	Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence	40420-40451	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	2840-2871	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	9258-9289	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	255385-255416	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	258938-258969	9	0.719
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	MT774389	CrAssphage cr116_1, complete genome	99438-99469	9	0.719
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	MN693034	Marine virus AFVG_117M74, complete genome	881-913	9	0.727
NZ_AP018280_2	2.1\|2568505\|34\|NZ_AP018280\|CRT	2568505-2568538	34	NZ_CP044357	Acinetobacter baumannii strain CAM180-1 plasmid pCAM180A, complete sequence	20976-21009	10	0.706
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	NZ_CP036488	Rahnella aquatilis strain MEM40 plasmid pMEM40-1, complete sequence	44588-44620	10	0.697
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	NZ_CP032297	Rahnella aquatilis strain ZF7 plasmid pRAZF7, complete sequence	518399-518431	10	0.697
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	NZ_CP034838	Rahnella aquatilis strain KM12 plasmid pKM12v1, complete sequence	130330-130362	10	0.697
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	NZ_CP034839	Rahnella aquatilis strain KM25 plasmid pKM12v2, complete sequence	130330-130362	10	0.697
NZ_AP018280_3	3.2\|3204479\|33\|NZ_AP018280\|CRISPRCasFinder,CRT	3204479-3204511	33	NZ_CP034837	Rahnella aquatilis strain KM05 plasmid pKM05, complete sequence	108242-108274	10	0.697
NZ_AP018280_3	3.4\|3204622\|34\|NZ_AP018280\|CRISPRCasFinder,CRT	3204622-3204655	34	NZ_CP049159	Caballeronia sp. SBC1 plasmid pSBC1_3, complete sequence	545566-545599	10	0.706
NZ_AP018280_3	3.4\|3204622\|34\|NZ_AP018280\|CRISPRCasFinder,CRT	3204622-3204655	34	NZ_CP049320	Caballeronia sp. SBC2 plasmid pSBC2-4, complete sequence	97719-97752	10	0.706
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	NZ_CP036488	Rahnella aquatilis strain MEM40 plasmid pMEM40-1, complete sequence	44587-44620	10	0.706
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	NZ_CP032297	Rahnella aquatilis strain ZF7 plasmid pRAZF7, complete sequence	518399-518432	10	0.706
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	NZ_CP054145	Deefgea sp. D17 plasmid unnamed2, complete sequence	14449-14482	10	0.706
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	NZ_CP034838	Rahnella aquatilis strain KM12 plasmid pKM12v1, complete sequence	130329-130362	10	0.706
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	NZ_CP034839	Rahnella aquatilis strain KM25 plasmid pKM12v2, complete sequence	130329-130362	10	0.706
NZ_AP018280_3	3.11\|3204478\|34\|NZ_AP018280\|PILER-CR	3204478-3204511	34	NZ_CP034837	Rahnella aquatilis strain KM05 plasmid pKM05, complete sequence	108241-108274	10	0.706
NZ_AP018280_7	7.1\|4007315\|32\|NZ_AP018280\|CRISPRCasFinder	4007315-4007346	32	NZ_CP026682	Nostoc sp. 'Peltigera membranacea cyanobiont' N6 plasmid pNPM1, complete sequence	164665-164696	10	0.688
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NC_017472	Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence	74361-74392	10	0.688
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP031668	Staphylococcus aureus strain 199 plasmid pPS00120.1A.1, complete sequence	8582-8613	10	0.688
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_CP031671	Staphylococcus aureus strain 64 plasmid pPS00119.1A.1, complete sequence	8583-8614	10	0.688
NZ_AP018280_8	8.1\|4659231\|32\|NZ_AP018280\|PILER-CR,CRT	4659231-4659262	32	NZ_LR130510	Staphylococcus aureus strain BPH2760 isolate BPH2760 plasmid 2	5482-5513	10	0.688
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	MT782071	Escherichia phage JN02, complete genome	29314-29346	10	0.697
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	KY703222	Escherichia phage phiC120, complete genome	118060-118092	10	0.697
NZ_AP018280_8	8.6\|4659230\|33\|NZ_AP018280\|CRISPRCasFinder	4659230-4659262	33	NC_017472	Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence	74361-74393	11	0.667

1. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to LR214964 (Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10) position: , mismatch: 6, identity: 0.812

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tgagcagcatctttatttaatttagaaattaa	Protospacer
*.* * . ******************** ***

2. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to MN693026 (Marine virus AFVG_117M72, complete genome) position: , mismatch: 6, identity: 0.812

taatctaaatctttatttaattt-agaaaataa	CRISPR spacer
taatctaaatttttgtttaatttcatctaata-	Protospacer
**********.***.******** *   ****

3. spacer 14.4|5991855|34|NZ_AP018280|PILER-CR,CRT matches to NZ_LR214952 (Mycoplasma neurolyticum strain NCTC10166 plasmid 2) position: , mismatch: 6, identity: 0.824

-aaatagcataaaaagaactgaatttaaaacttag	CRISPR spacer
taaataa-agaaaaaaaacttaatttaaaacttaa	Protospacer
 *****. * *****.**** *************.

4. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024793 (Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaa---aaccacgaactacgaactacgaattac	CRISPR spacer
---aacttaattacgaattacgaattacgaattac	Protospacer
   **   **..*****.******.**********

5. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024793 (Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaa---aaccacgaactacgaactacgaattac	CRISPR spacer
---aacttaattacgaattacgaattacgaattac	Protospacer
   **   **..*****.******.**********

6. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024793 (Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaa---aaccacgaactacgaactacgaattac	CRISPR spacer
---aacttaattacgaattacgaattacgaattac	Protospacer
   **   **..*****.******.**********

7. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

8. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

9. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

10. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

11. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

12. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

13. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

14. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ccgataattacgaattacgaattacgaattac	Protospacer
*..* **..*****.******.**********

15. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

16. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

17. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

18. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

19. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

20. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
caagtaattacgaattacgaattacgaattac	Protospacer
* *. **..*****.******.**********

21. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

22. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

23. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

24. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
ttacgaattacgaattacgaattacgaattac	Protospacer
.** .**..*****.******.**********

25. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to MH884509 (Bacillus phage vB_BboS-125, complete genome) position: , mismatch: 7, identity: 0.781

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
atgaacagcacgaactacgaactacgaagaag	Protospacer
 *.** * ********************  *

26. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to MH319754 (Marine virus AG-345-L05 Ga0172272_11 genomic sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aagaataaatctttatttaaattaaaaaatat	Protospacer
 *.  *************** ***.******

27. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP004877 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB431, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

28. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP031069 (Bacillus sp. JAS24-2 plasmid pl626, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

29. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011350 (Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

30. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP022446 (Bacillus cereus C1L plasmid pC1L1, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

31. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP044979 (Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

32. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP007616 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB400, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

33. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP004860 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB422, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

34. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP007513 (Bacillus bombysepticus plasmid pBb, complete genome) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

35. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to CP046512 (Bacillus cereus strain JHU plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

36. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP042875 (Bacillus cereus strain 09 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

37. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011154 (Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

38. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011152 (Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

39. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

40. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NC_020385 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

41. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP050184 (Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

42. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP021062 (Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgtataaatctttatttgatttagaaaccac	Protospacer
* .* *************.********* .*

43. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP014284 (Bacillus thuringiensis strain Bt185 plasmid pBT1850294, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tcacctaattctttatttaatttataatagat	Protospacer
* *.**** *************** ** * *

44. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatctaaatatttttttaatttattatctaa	Protospacer
 ********* *** *********  *  ***

45. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP032609 (Bacillus thuringiensis strain QZL38 plasmid p.2, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tcacctaattctttatttaatttataatagat	Protospacer
* *.**** *************** ** * *

46. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP023312 (Vibrio anguillarum strain VIB12 isolate Sea bass plasmid p292, complete sequence) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tgctttaaatcgttatttaattgagaaattga	Protospacer
*. *.****** ********** ***** *.*

47. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to AY082070 (Bacteriophage phi3626, complete genome) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttatctaaatcactatttaatttagttaagta	Protospacer
* ********* .************  **  *

48. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NC_003524 (Clostridium phage phi3626, complete genome) position: , mismatch: 7, identity: 0.781

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttatctaaatcactatttaatttagttaagta	Protospacer
* ********* .************  **  *

49. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to LR214964 (Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10) position: , mismatch: 7, identity: 0.788

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
ttgagcagcatctttatttaatttagaaattaa	Protospacer
 *.* * . ******************** ***

50. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to JN638751 (Bacillus phage G, complete genome) position: , mismatch: 8, identity: 0.758

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
ctttacggattgataaattgaatcaaatgtgta	Protospacer
.*  **  .********** ********** **

51. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 8, identity: 0.75

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
attctaattacgaattacgaattacgaattac	Protospacer
 *   **..*****.******.**********

52. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to MN694459 (Marine virus AFVG_250M532, complete genome) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tttgatgaatttttatttaattttgaaaatat	Protospacer
*    *.***.************ *******

53. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatgtatatctttatttaatttaatttctaa	Protospacer
 *** ** ****************.    ***

54. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatgtatatctttatttaatttaatttctaa	Protospacer
 *** ** ****************.    ***

55. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatgtatatctttatttaatttaatttctaa	Protospacer
 *** ** ****************.    ***

56. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP013700 (Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatgtatatctttatttaatttaatttctaa	Protospacer
 *** ** ****************.    ***

57. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to AP014182 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S41-C49, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatctaaatctttatctaatgtaactcctaa	Protospacer
 ***************.**** **.    ***

58. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to AP014181 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S40-C70, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatctaaatctttatctaatgtaactcctaa	Protospacer
 ***************.**** **.    ***

59. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to AP014183 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S42-C67, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatctaaatctttatctaatgtaactcctaa	Protospacer
 ***************.**** **.    ***

60. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to MH319754 (Marine virus AG-345-L05 Ga0172272_11 genomic sequence) position: , mismatch: 8, identity: 0.758

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
taagaataaatctttatttaaattaaaaaatat	Protospacer
  *.  *************** ***.******

61. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to MN694459 (Marine virus AFVG_250M532, complete genome) position: , mismatch: 8, identity: 0.758

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
atttgatgaatttttatttaattttgaaaatat	Protospacer
**    *.***.************ *******

62. spacer 2.1|2568505|34|NZ_AP018280|CRT matches to NZ_AP018256 (Calothrix sp. NIES-4071 plasmid plasmid1 DNA, complete genome) position: , mismatch: 9, identity: 0.735

ctaaaacctaacgatattattgcaatcgatatcg	CRISPR spacer
ataaaacctaacgatataactgcaatgaaaaatt	Protospacer
 **************** *.****** .* * .

63. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP054145 (Deefgea sp. D17 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.727

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
gtattcctgttgcaaaattcaatcaaatggcaa	Protospacer
 *.  *******  *************** . *

64. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to JN638751 (Bacillus phage G, complete genome) position: , mismatch: 9, identity: 0.735

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
cctttacggattgataaattgaatcaaatgtgta	Protospacer
 .*  **  .********** ********** **

65. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024793 (Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence) position: , mismatch: 9, identity: 0.719

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
gggttaattacgaattacgaattacgaattac	Protospacer
  .  **..*****.******.**********

66. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024793 (Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence) position: , mismatch: 9, identity: 0.719

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
gatttaattacgaattacgaattacgaattac	Protospacer
     **..*****.******.**********

67. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024793 (Nostoc flagelliforme CCNUN1 plasmid pNFSY08, complete sequence) position: , mismatch: 9, identity: 0.719

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
gatttaattacgaattacgaattacgaattac	Protospacer
     **..*****.******.**********

68. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP051207 (Dolichospermum flos-aquae CCAP 1403/13F plasmid pAfl69, complete sequence) position: , mismatch: 9, identity: 0.719

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
tcttcaattacgaattacgaattacgaattac	Protospacer
..   **..*****.******.**********

69. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP024791 (Nostoc flagelliforme CCNUN1 plasmid pNFSY06, complete sequence) position: , mismatch: 9, identity: 0.719

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
gatttaattacgaattacgaattacgaattac	Protospacer
     **..*****.******.**********

70. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to AP017993 (Planktothrix agardhii NIES-204 plasmid plasmid2 DNA, complete sequence) position: , mismatch: 9, identity: 0.719

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
tagggaattacgaattacgaattacgaattac	Protospacer
. ...**..*****.******.**********

71. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to MT782071 (Escherichia phage JN02, complete genome) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ccgtctaaatctttatgtaatttagcaagagc	Protospacer
. .************* ******** **. .

72. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to KY703222 (Escherichia phage phiC120, complete genome) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
ccgtctaaatctttatgtaatttagcaagagc	Protospacer
. .************* ******** **. .

73. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to MN693034 (Marine virus AFVG_117M74, complete genome) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
atccctaactctttatttaatttagtaatttc	Protospacer
   .**** **************** ** *

74. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP017256 (Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tttttataaactttatttaatttagaatattt	Protospacer
*  *.  ** ***************** **

75. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatcaaaatctttatataatttatatttata	Protospacer
 **** ********** ******* *     *

76. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatcaaaatctttatataatttatatttata	Protospacer
 **** ********** ******* *     *

77. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatcaaaatctttatataatttatatttata	Protospacer
 **** ********** ******* *     *

78. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
aaatcaaaatctttatataatttatatttata	Protospacer
 **** ********** ******* *     *

79. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to MT774389 (CrAssphage cr116_1, complete genome) position: , mismatch: 9, identity: 0.719

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
tcatctaaatctttaattaacttaggtatagt	Protospacer
* ************* ****.****. *  .

80. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to MN693034 (Marine virus AFVG_117M74, complete genome) position: , mismatch: 9, identity: 0.727

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
aatccctaactctttatttaatttagtaatttc	Protospacer
*   .**** **************** ** *

81. spacer 2.1|2568505|34|NZ_AP018280|CRT matches to NZ_CP044357 (Acinetobacter baumannii strain CAM180-1 plasmid pCAM180A, complete sequence) position: , mismatch: 10, identity: 0.706

ctaaaacctaacgatattattgcaatcgatatcg	CRISPR spacer
gtaaaacctaaggatattattgtaagttgttctg	Protospacer
 ********** **********.** . .* ..*

82. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP036488 (Rahnella aquatilis strain MEM40 plasmid pMEM40-1, complete sequence) position: , mismatch: 10, identity: 0.697

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
acacaggtgatgataaatccaatcaaatgttat	Protospacer
 .. *  ** ********.************

83. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP032297 (Rahnella aquatilis strain ZF7 plasmid pRAZF7, complete sequence) position: , mismatch: 10, identity: 0.697

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
acacaggtgatgataaatccaatcaaatgttat	Protospacer
 .. *  ** ********.************

84. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP034838 (Rahnella aquatilis strain KM12 plasmid pKM12v1, complete sequence) position: , mismatch: 10, identity: 0.697

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
acacaggtgatgataaatccaatcaaatgttat	Protospacer
 .. *  ** ********.************

85. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP034839 (Rahnella aquatilis strain KM25 plasmid pKM12v2, complete sequence) position: , mismatch: 10, identity: 0.697

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
acacaggtgatgataaatccaatcaaatgttat	Protospacer
 .. *  ** ********.************

86. spacer 3.2|3204479|33|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP034837 (Rahnella aquatilis strain KM05 plasmid pKM05, complete sequence) position: , mismatch: 10, identity: 0.697

ttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
acacaggtgatgataaatccaatcaaatgttat	Protospacer
 .. *  ** ********.************

87. spacer 3.4|3204622|34|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP049159 (Caballeronia sp. SBC1 plasmid pSBC1_3, complete sequence) position: , mismatch: 10, identity: 0.706

gcgaatttccgcttcctgtgctgccaattcccct	CRISPR spacer
ccgcatttccgcttgctgtgctgccgttgtcgag	Protospacer
 ** ********** **********. * .*

88. spacer 3.4|3204622|34|NZ_AP018280|CRISPRCasFinder,CRT matches to NZ_CP049320 (Caballeronia sp. SBC2 plasmid pSBC2-4, complete sequence) position: , mismatch: 10, identity: 0.706

gcgaatttccgcttcctgtgctgccaattcccct	CRISPR spacer
ccgcatttccgcttgctgtgctgccgttgtcgag	Protospacer
 ** ********** **********. * .*

89. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to NZ_CP036488 (Rahnella aquatilis strain MEM40 plasmid pMEM40-1, complete sequence) position: , mismatch: 10, identity: 0.706

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
gacacaggtgatgataaatccaatcaaatgttat	Protospacer
* .. *  ** ********.************

90. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to NZ_CP032297 (Rahnella aquatilis strain ZF7 plasmid pRAZF7, complete sequence) position: , mismatch: 10, identity: 0.706

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
gacacaggtgatgataaatccaatcaaatgttat	Protospacer
* .. *  ** ********.************

91. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to NZ_CP054145 (Deefgea sp. D17 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.706

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
cgtattcctgttgcaaaattcaatcaaatggcaa	Protospacer
  *.  *******  *************** . *

92. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to NZ_CP034838 (Rahnella aquatilis strain KM12 plasmid pKM12v1, complete sequence) position: , mismatch: 10, identity: 0.706

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
gacacaggtgatgataaatccaatcaaatgttat	Protospacer
* .. *  ** ********.************

93. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to NZ_CP034839 (Rahnella aquatilis strain KM25 plasmid pKM12v2, complete sequence) position: , mismatch: 10, identity: 0.706

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
gacacaggtgatgataaatccaatcaaatgttat	Protospacer
* .. *  ** ********.************

94. spacer 3.11|3204478|34|NZ_AP018280|PILER-CR matches to NZ_CP034837 (Rahnella aquatilis strain KM05 plasmid pKM05, complete sequence) position: , mismatch: 10, identity: 0.706

gttgaacctgttgataaattcaatcaaatgttta	CRISPR spacer
gacacaggtgatgataaatccaatcaaatgttat	Protospacer
* .. *  ** ********.************

95. spacer 7.1|4007315|32|NZ_AP018280|CRISPRCasFinder matches to NZ_CP026682 (Nostoc sp. 'Peltigera membranacea cyanobiont' N6 plasmid pNPM1, complete sequence) position: , mismatch: 10, identity: 0.688

ctaaaaaccacgaactacgaactacgaattac	CRISPR spacer
agcgtcattacgaattacgaattacgaattac	Protospacer
   .  *..*****.******.**********

96. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NC_017472 (Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence) position: , mismatch: 10, identity: 0.688

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
atctctaaatctttatttgatatagaagtagc	Protospacer
   ***************.** *****.  .

97. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP031668 (Staphylococcus aureus strain 199 plasmid pPS00120.1A.1, complete sequence) position: , mismatch: 10, identity: 0.688

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
atttttaaatctttatttgatttagtaatacc	Protospacer
   *.*************.****** **

98. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_CP031671 (Staphylococcus aureus strain 64 plasmid pPS00119.1A.1, complete sequence) position: , mismatch: 10, identity: 0.688

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
atttttaaatctttatttgatttagtaatacc	Protospacer
   *.*************.****** **

99. spacer 8.1|4659231|32|NZ_AP018280|PILER-CR,CRT matches to NZ_LR130510 (Staphylococcus aureus strain BPH2760 isolate BPH2760 plasmid 2) position: , mismatch: 10, identity: 0.688

taatctaaatctttatttaatttagaaaataa	CRISPR spacer
atttttaaatctttatttgatttagtaatacc	Protospacer
   *.*************.****** **

100. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to MT782071 (Escherichia phage JN02, complete genome) position: , mismatch: 10, identity: 0.697

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
gccgtctaaatctttatgtaatttagcaagagc	Protospacer
.. .************* ******** **. .

101. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to KY703222 (Escherichia phage phiC120, complete genome) position: , mismatch: 10, identity: 0.697

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
gccgtctaaatctttatgtaatttagcaagagc	Protospacer
.. .************* ******** **. .

102. spacer 8.6|4659230|33|NZ_AP018280|CRISPRCasFinder matches to NC_017472 (Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence) position: , mismatch: 11, identity: 0.667

ataatctaaatctttatttaatttagaaaataa	CRISPR spacer
tatctctaaatctttatttgatatagaagtagc	Protospacer
    ***************.** *****.  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

9616 : 52537

Pseudomonas_phage(40.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096614156.1\|9616_10441_+\|transposase	transposase	NA	NA	NA	NA
WP_096614158.1\|10437_10896_+	hypothetical protein	NA	NA	NA	NA
WP_096614161.1\|11142_11820_-	glycosyltransferase	NA	NA	NA	NA
WP_096618325.1\|11934_12369_-	hypothetical protein	NA	NA	NA	NA
WP_096611141.1\|12479_13781_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096614163.1\|14682_15840_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_096614154.1\|15973_16297_+	hypothetical protein	A0A0U4J920	Pseudomonas_phage	3.7e-07	39.7
WP_096613539.1\|17944_19756_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	4.6e-94	39.8
WP_096614152.1\|19748_21062_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_096614150.1\|21208_22117_+	hypothetical protein	NA	NA	NA	NA
WP_096618324.1\|22269_22950_+	HNH endonuclease	NA	NA	NA	NA
WP_096614165.1\|24575_26495_-	hypothetical protein	NA	NA	NA	NA
WP_096614167.1\|26571_27006_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_096613173.1\|28370_29606_-	hypothetical protein	NA	NA	NA	NA
WP_096609154.1\|29640_29928_-	hypothetical protein	NA	NA	NA	NA
WP_096618326.1\|30863_31118_-	hypothetical protein	NA	NA	NA	NA
WP_096614169.1\|31594_33148_+	SAM-dependent DNA methyltransferase	A0A220A2U4	Liberibacter_phage	4.1e-67	31.9
WP_096614171.1\|33195_33618_+	hypothetical protein	NA	NA	NA	NA
WP_096614173.1\|34669_35578_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_096614175.1\|35580_37593_+	transcriptional regulator	NA	NA	NA	NA
WP_096614177.1\|37613_40544_+	restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	6.5e-82	29.2
WP_096614179.1\|40533_40851_+	M48 family peptidase	NA	NA	NA	NA
WP_096618327.1\|40876_41380_-	hypothetical protein	NA	NA	NA	NA
WP_096614181.1\|41379_42228_-\|transposase	transposase	NA	NA	NA	NA
WP_096612537.1\|43606_45094_+\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_096612700.1\|47635_48766_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096614183.1\|48917_50108_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_096614185.1\|50367_50643_+	hypothetical protein	NA	NA	NA	NA
WP_096614187.1\|50806_51325_-	N-acetylmuramoyl-L-alanine amidase	A0A0S2MWH1	Cellulophaga_phage	3.9e-06	30.4
WP_096614189.1\|51324_51546_-	hypothetical protein	NA	NA	NA	NA
WP_096614191.1\|51538_52537_-\|transposase	IS630 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

783145 : 929722

105

Bacillus_phage(22.22%)

integrase,tail,plate,transposase

attL 838370:838385|attR 886264:886279

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096610164.1\|783145_784288_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_096614813.1\|784305_784521_-	hypothetical protein	NA	NA	NA	NA
WP_096614814.1\|784878_785616_-	DUF928 domain-containing protein	NA	NA	NA	NA
WP_096614815.1\|785608_788137_-	CHASE2 domain-containing protein	NA	NA	NA	NA
WP_096614816.1\|788198_792788_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096614817.1\|793069_793276_+	hypothetical protein	NA	NA	NA	NA
WP_096614818.1\|793364_793556_+	hypothetical protein	NA	NA	NA	NA
WP_096614819.1\|793516_793744_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_096614820.1\|793820_794732_-	DUF4351 domain-containing protein	NA	NA	NA	NA
WP_096614714.1\|794775_796137_-	DUF1822 domain-containing protein	NA	NA	NA	NA
WP_096614715.1\|796139_797540_-	hypothetical protein	NA	NA	NA	NA
WP_096614821.1\|800235_800448_-	hypothetical protein	NA	NA	NA	NA
WP_096614822.1\|800719_802135_+	hypothetical protein	NA	NA	NA	NA
WP_096614823.1\|802235_802604_+	hypothetical protein	NA	NA	NA	NA
WP_096614824.1\|802618_802873_-	hypothetical protein	NA	NA	NA	NA
WP_096614825.1\|803437_806905_+	caspase	NA	NA	NA	NA
WP_096614826.1\|807227_810632_+	CHAT domain-containing protein	NA	NA	NA	NA
WP_096612537.1\|810889_812377_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_096614827.1\|812488_812785_+	CHAT domain-containing protein	NA	NA	NA	NA
WP_096614828.1\|812726_817358_+	NACHT domain-containing protein	NA	NA	NA	NA
WP_096614829.1\|817409_818423_+	caspase family protein	NA	NA	NA	NA
WP_096614830.1\|820040_821843_+	WD40 repeat domain-containing protein	NA	NA	NA	NA
WP_096614831.1\|823729_824995_+	hypothetical protein	NA	NA	NA	NA
WP_096614832.1\|826061_826733_+	hypothetical protein	S5WII0	Leptospira_phage	5.8e-10	39.8
WP_096613183.1\|826708_827779_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096614833.1\|828091_828562_+	hypothetical protein	NA	NA	NA	NA
WP_096614834.1\|828599_829433_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_096614835.1\|829509_829965_+	N-acetyltransferase	NA	NA	NA	NA
WP_096618380.1\|830094_830721_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_096614836.1\|831000_831426_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_096614837.1\|831810_832872_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_096614838.1\|832945_833173_+	hypothetical protein	NA	NA	NA	NA
WP_096614839.1\|833203_833635_+	HIT domain-containing protein	NA	NA	NA	NA
WP_096614840.1\|833747_836558_+	CHAT domain-containing protein	NA	NA	NA	NA
WP_096614841.1\|836565_836964_-	hypothetical protein	NA	NA	NA	NA
WP_096614842.1\|837219_837759_-	hypothetical protein	NA	NA	NA	NA
WP_096614843.1\|837785_838358_-	methyltransferase	NA	NA	NA	NA
838370:838385	attL	NA	NA	NA	NA
WP_096614844.1\|838567_839698_+	hypothetical protein	NA	NA	NA	NA
WP_096614845.1\|839723_840689_+	DUF1822 domain-containing protein	NA	NA	NA	NA
WP_096613173.1\|841060_842296_-	hypothetical protein	NA	NA	NA	NA
WP_096609659.1\|842367_842619_-	hypothetical protein	NA	NA	NA	NA
WP_096614846.1\|842659_845827_+	peptidase	NA	NA	NA	NA
WP_096614847.1\|846225_846831_-	Uma2 family endonuclease	NA	NA	NA	NA
WP_096614848.1\|847020_847533_-	hypothetical protein	NA	NA	NA	NA
WP_096614849.1\|849447_851193_+\|tail	phage tail protein	J9PVC2	Bacillus_phage	1.9e-41	33.7
WP_096614850.1\|851329_851857_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096614851.1\|851967_852699_+\|plate	phage baseplate protein	NA	NA	NA	NA
WP_096614852.1\|852695_853607_+	hypothetical protein	NA	NA	NA	NA
WP_096614853.1\|853603_854947_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_096614854.1\|854988_857070_+	ATP-binding protein	A0A109WUE1	Acidianus_tailed_spindle_virus	3.4e-08	33.3
WP_096614855.1\|857066_857324_+	hypothetical protein	NA	NA	NA	NA
WP_096614856.1\|857320_859036_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_096614857.1\|860906_862850_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_096614858.1\|863148_863808_+	hypothetical protein	NA	NA	NA	NA
WP_096614859.1\|863804_864176_+	LysM domain-containing protein	NA	NA	NA	NA
WP_096614860.1\|864168_865293_+	hypothetical protein	NA	NA	NA	NA
WP_096614861.1\|865289_865826_+\|plate	baseplate assembly protein	J9PUM0	Bacillus_phage	6.9e-06	35.3
WP_096614862.1\|865841_866198_+	hypothetical protein	NA	NA	NA	NA
WP_096614863.1\|866285_866645_+	hypothetical protein	NA	NA	NA	NA
WP_096614864.1\|866644_869230_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_096614865.1\|869382_872721_+\|plate	putative baseplate assembly protein	A0A1J0GW37	Streptomyces_phage	6.4e-17	28.3
WP_096614866.1\|872788_875032_+	hypothetical protein	NA	NA	NA	NA
WP_096614867.1\|875083_876541_+	hypothetical protein	NA	NA	NA	NA
WP_096614868.1\|876558_877464_+	hypothetical protein	NA	NA	NA	NA
WP_096614869.1\|877770_878115_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_096614870.1\|878095_878482_-	addiction module toxin RelE	NA	NA	NA	NA
WP_096614871.1\|879107_880271_+\|integrase	site-specific integrase	G9BWC1	Planktothrix_phage	1.6e-55	35.5
WP_096614872.1\|880386_881112_-	oxidoreductase	NA	NA	NA	NA
WP_096614873.1\|881191_881800_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_096614874.1\|882064_882694_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_096614875.1\|882826_884041_+	glycosyltransferase	NA	NA	NA	NA
WP_096614876.1\|885923_886271_+	hypothetical protein	NA	NA	NA	NA
WP_096614877.1\|886369_886825_+	phosphatase	NA	NA	NA	NA
886264:886279	attR	NA	NA	NA	NA
WP_096614703.1\|886885_887260_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_096614878.1\|890559_890799_+	hypothetical protein	NA	NA	NA	NA
WP_096614879.1\|891282_892071_+	vancomycin resistance protein	NA	NA	NA	NA
WP_096614880.1\|892063_893104_+	malate dehydrogenase	NA	NA	NA	NA
WP_096618381.1\|893372_894938_-	murein biosynthesis integral membrane protein MurJ	NA	NA	NA	NA
WP_096614881.1\|894918_895920_-	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_096618382.1\|896086_897190_-	KamA family radical SAM protein	NA	NA	NA	NA
WP_096614882.1\|898735_899356_-	GTP-binding protein	NA	NA	NA	NA
WP_096614883.1\|899834_901970_+	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	4.6e-45	25.9
WP_096614884.1\|902403_902679_-	MoaD/ThiS family protein	NA	NA	NA	NA
WP_096614885.1\|903055_904354_-	threonine synthase	NA	NA	NA	NA
WP_096614886.1\|904917_907095_+	cell envelope biogenesis protein OmpA	NA	NA	NA	NA
WP_096609602.1\|907192_908419_-\|transposase	transposase	NA	NA	NA	NA
WP_096614887.1\|908582_909368_+	hypothetical protein	NA	NA	NA	NA
WP_096614888.1\|909959_910778_+	serine O-acetyltransferase	NA	NA	NA	NA
WP_096614889.1\|910780_911026_+	hypothetical protein	NA	NA	NA	NA
WP_096614890.1\|911181_911379_+	DUF2949 domain-containing protein	NA	NA	NA	NA
WP_096614891.1\|911964_913101_+	homocitrate synthase	NA	NA	NA	NA
WP_096614892.1\|913084_913372_+	nitrogen fixation protein NifZ	NA	NA	NA	NA
WP_096614893.1\|913368_913572_+	putative nitrogen fixation protein NifT	NA	NA	NA	NA
WP_096614894.1\|914084_914723_+	DNA-binding protein	NA	NA	NA	NA
WP_096614895.1\|915015_915549_+	DUF4330 domain-containing protein	NA	NA	NA	NA
WP_096614896.1\|915917_918080_+	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	1.4e-20	30.7
WP_096618383.1\|918097_918523_+	response regulator	NA	NA	NA	NA
WP_096614897.1\|918691_920965_+	PAS domain S-box protein	Q6XLV6	Feldmannia_irregularis_virus	1.4e-12	23.0
WP_096614898.1\|923022_923565_+	phycobiliprotein lyase	NA	NA	NA	NA
WP_096614899.1\|923601_924216_+	phycobiliprotein lyase	NA	NA	NA	NA
WP_096614900.1\|924409_925141_+	dihydrobiliverdin:ferredoxin oxidoreductase	NA	NA	NA	NA
WP_096614901.1\|925190_925946_+	phycoerythrobilin:ferredoxin oxidoreductase	NA	NA	NA	NA
WP_096614902.1\|925966_926770_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_096614903.1\|927593_928652_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096618384.1\|928501_929722_-\|transposase	ISL3 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2977863 : 2984920

Pseudomonas_phage(28.57%)

capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096616739.1\|2977863_2978307_-	DUF1320 domain-containing protein	A0A0A1IX76	Pseudomonas_phage	3.4e-11	37.8
WP_096616741.1\|2978510_2978735_-	hypothetical protein	NA	NA	NA	NA
WP_096616743.1\|2978743_2979700_-\|capsid	phage capsid protein	B5TA95	Burkholderia_phage	1.1e-54	38.9
WP_096618497.1\|2979727_2980165_-	DUF2190 domain-containing protein	A0A0S4L3C3	Pseudomonas_phage	3.9e-15	45.0
WP_096616745.1\|2980173_2981343_-	hypothetical protein	Q6QIB7	Burkholderia_phage	9.0e-51	38.1
WP_096616747.1\|2981377_2981593_-	hypothetical protein	NA	NA	NA	NA
WP_096616749.1\|2981602_2982049_-	phage virion morphogenesis protein	A0A2H4J9E5	uncultured_Caudovirales_phage	4.5e-11	30.5
WP_096616751.1\|2982058_2982556_-	hypothetical protein	NA	NA	NA	NA
WP_096616753.1\|2982555_2983380_-	hypothetical protein	NA	NA	NA	NA
WP_096616755.1\|2983369_2984146_-	hypothetical protein	A0A2H4PAR7	Aphanizomenon_phage	1.5e-38	34.5
WP_096616757.1\|2984152_2984920_-	hypothetical protein	A0A2H5BK13	Erwinia_phage	2.4e-36	46.9

DBSCAN-SWA_4

4132392 : 4201295

Bacillus_phage(28.57%)

protease,integrase,transposase

attL 4159807:4159822|attR 4177541:4177556

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096618212.1\|4132392_4133880_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_096618213.1\|4135358_4135685_+	hypothetical protein	NA	NA	NA	NA
WP_096618214.1\|4135873_4136302_+	hypothetical protein	NA	NA	NA	NA
WP_096618215.1\|4136525_4137185_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_096618216.1\|4137193_4137658_+\|protease	hydrogenase maturation protease	NA	NA	NA	NA
WP_096618217.1\|4137843_4138221_-	hypothetical protein	NA	NA	NA	NA
WP_096618218.1\|4140124_4140271_+	hypothetical protein	NA	NA	NA	NA
WP_096618219.1\|4140813_4141416_-	CBS domain-containing protein	NA	NA	NA	NA
WP_096618220.1\|4142648_4142948_-	ferredoxin	A0A222YX16	Synechococcus_phage	4.5e-23	54.7
WP_096618221.1\|4143146_4143518_-	iron-sulfur cluster assembly accessory protein	NA	NA	NA	NA
WP_096618222.1\|4143672_4143876_-	hypothetical protein	NA	NA	NA	NA
WP_096618223.1\|4143882_4144680_-	HesA/MoeB/ThiF family protein	NA	NA	NA	NA
WP_096618224.1\|4144690_4145008_-	nitrogenase stabilizing/protective protein	NA	NA	NA	NA
WP_096618225.1\|4145004_4145235_-	hypothetical protein	NA	NA	NA	NA
WP_096618226.1\|4145234_4145711_-	DUF269 domain-containing protein	NA	NA	NA	NA
WP_096618227.1\|4145707_4146121_-	nitrogen fixation protein NifX	NA	NA	NA	NA
WP_096618228.1\|4146295_4147615_-	nitrogenase iron-molybdenum cofactor biosynthesis protein NifN	NA	NA	NA	NA
WP_096618229.1\|4147731_4149162_-	nitrogenase iron-molybdenum cofactor biosynthesis protein NifE	NA	NA	NA	NA
WP_096618230.1\|4149920_4151471_+	recombinase family protein	A0A2P1N2W7	Gordonia_phage	4.6e-10	22.9
WP_096618231.1\|4151928_4152423_-	translation initiation factor IF-3	NA	NA	NA	NA
WP_096618232.1\|4152883_4153183_+	RNA-binding protein	NA	NA	NA	NA
WP_096618233.1\|4153644_4154154_+	fatty acid hydroxylase	NA	NA	NA	NA
WP_096618234.1\|4154398_4155451_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.3e-21	24.3
WP_096618235.1\|4155506_4156715_-	chromate transporter	NA	NA	NA	NA
WP_096618236.1\|4156884_4157922_-	NADP(H)-dependent aldo-keto reductase	NA	NA	NA	NA
WP_096618237.1\|4158460_4159765_-	nitrogenase molybdenum-iron protein subunit beta	NA	NA	NA	NA
4159807:4159822	attL	NA	NA	NA	NA
WP_096618238.1\|4160346_4161660_+\|integrase	integrase	NA	NA	NA	NA
WP_096618239.1\|4161904_4163995_-	elongation factor G	E4ZFJ7	Streptococcus_phage	7.9e-66	29.8
WP_096618240.1\|4165085_4165388_+	hypothetical protein	NA	NA	NA	NA
WP_096618569.1\|4165579_4165978_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_096618570.1\|4166061_4166343_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_096618241.1\|4166475_4166967_+	DUF4174 domain-containing protein	NA	NA	NA	NA
WP_096618242.1\|4167758_4169681_+	hypothetical protein	NA	NA	NA	NA
WP_096618243.1\|4169903_4170536_+	glutathione S-transferase	NA	NA	NA	NA
WP_096618244.1\|4172993_4173845_-	DUF1206 domain-containing protein	NA	NA	NA	NA
WP_096618245.1\|4174004_4174580_-	hypothetical protein	NA	NA	NA	NA
WP_096618246.1\|4174704_4175724_+	hypothetical protein	NA	NA	NA	NA
WP_096614305.1\|4177448_4178714_+\|transposase	IS701 family transposase	NA	NA	NA	NA
4177541:4177556	attR	NA	NA	NA	NA
WP_096618247.1\|4179121_4179574_-	peptidase M48 Ste24p	NA	NA	NA	NA
WP_096618248.1\|4179769_4180573_-	hypothetical protein	NA	NA	NA	NA
WP_096618249.1\|4180610_4180856_-	hypothetical protein	NA	NA	NA	NA
WP_096618250.1\|4181159_4181729_-	DUF3611 domain-containing protein	NA	NA	NA	NA
WP_096618251.1\|4182140_4182512_-	response regulator	W8CYM9	Bacillus_phage	1.4e-10	34.7
WP_096618252.1\|4182704_4184381_+	PAS domain S-box protein	A0A1B0VMK3	Pseudomonas_phage	9.0e-12	27.6
WP_096618253.1\|4184496_4184985_-	DUF1772 domain-containing protein	NA	NA	NA	NA
WP_096618254.1\|4185333_4187166_+	transcriptional regulator	W8CYM9	Bacillus_phage	1.5e-28	33.3
WP_096618255.1\|4187294_4188329_+	AI-2E family transporter	NA	NA	NA	NA
WP_096618256.1\|4188672_4189116_+	SH3 domain-containing protein	NA	NA	NA	NA
WP_096618257.1\|4189161_4189743_-	hypothetical protein	NA	NA	NA	NA
WP_096618258.1\|4189787_4191137_-	DUF2254 domain-containing protein	NA	NA	NA	NA
WP_096618259.1\|4191133_4192141_-	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_096618260.1\|4192173_4192986_-	potassium channel protein	NA	NA	NA	NA
WP_096618261.1\|4192994_4194278_-	TIGR00341 family protein	NA	NA	NA	NA
WP_096618262.1\|4194636_4195020_+	hypothetical protein	NA	NA	NA	NA
WP_096618263.1\|4194945_4196343_-	9-cis-epoxycarotenoid dioxygenase	NA	NA	NA	NA
WP_096618264.1\|4197292_4197982_-	short-chain dehydrogenase	NA	NA	NA	NA
WP_096610996.1\|4198129_4199053_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_096618265.1\|4199113_4199728_+	DDE endonuclease	NA	NA	NA	NA
WP_096618266.1\|4200470_4201295_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_5

4234792 : 4284106

Bacteriophage(33.33%)

transposase,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096618292.1\|4234792_4235611_-\|terminase	phage terminase large subunit family protein	NA	NA	NA	NA
WP_096618293.1\|4235610_4235841_-	hypothetical protein	NA	NA	NA	NA
WP_096618294.1\|4235824_4236088_-	hypothetical protein	NA	NA	NA	NA
WP_096611141.1\|4236733_4238035_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096618295.1\|4238418_4238817_-	hypothetical protein	NA	NA	NA	NA
WP_096618296.1\|4239234_4239654_+	hypothetical protein	NA	NA	NA	NA
WP_096618297.1\|4239777_4240197_-	PIN domain-containing protein	NA	NA	NA	NA
WP_096618571.1\|4240193_4240472_-	hypothetical protein	NA	NA	NA	NA
WP_096618298.1\|4240706_4241516_-	hypothetical protein	NA	NA	NA	NA
WP_096618299.1\|4241938_4242148_-	hypothetical protein	NA	NA	NA	NA
WP_096618300.1\|4242413_4242677_-	hypothetical protein	A0A1L2BWY6	Bacteriophage	1.5e-06	45.1
WP_096618301.1\|4242883_4243474_+	hypothetical protein	NA	NA	NA	NA
WP_096618302.1\|4243564_4244662_+	hypothetical protein	NA	NA	NA	NA
WP_096618303.1\|4244875_4245100_+	hypothetical protein	NA	NA	NA	NA
WP_096618304.1\|4245089_4245482_+	PIN domain-containing protein	NA	NA	NA	NA
WP_096618305.1\|4245467_4246046_-	hypothetical protein	NA	NA	NA	NA
WP_096612048.1\|4246039_4246540_-\|transposase	transposase	NA	NA	NA	NA
WP_096611667.1\|4246793_4248329_-\|transposase	transposase	NA	NA	NA	NA
WP_096618306.1\|4248427_4250137_+	hypothetical protein	NA	NA	NA	NA
WP_096614753.1\|4250136_4251333_+	AAA family ATPase	NA	NA	NA	NA
WP_096614754.1\|4251532_4253101_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_096618307.1\|4253929_4254154_+	hypothetical protein	NA	NA	NA	NA
WP_096618308.1\|4254244_4254427_+	hypothetical protein	NA	NA	NA	NA
WP_096618309.1\|4254984_4255353_+	hypothetical protein	NA	NA	NA	NA
WP_096618310.1\|4255349_4258466_-	CHAT domain-containing protein	NA	NA	NA	NA
WP_096618311.1\|4259056_4259299_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_096618312.1\|4260780_4261287_-	hypothetical protein	NA	NA	NA	NA
WP_096613173.1\|4261283_4262519_-	hypothetical protein	NA	NA	NA	NA
WP_096609659.1\|4262590_4262842_-	hypothetical protein	NA	NA	NA	NA
WP_096613169.1\|4265672_4266185_-	hypothetical protein	NA	NA	NA	NA
WP_096613167.1\|4266249_4266795_-	hypothetical protein	NA	NA	NA	NA
WP_096613165.1\|4267231_4267786_-	dihydrofolate reductase	NA	NA	NA	NA
WP_096613163.1\|4267908_4268772_-	aminoglycoside phosphotransferase family protein	NA	NA	NA	NA
WP_096613161.1\|4269212_4270277_+	ribosome small subunit-dependent GTPase A	NA	NA	NA	NA
WP_096613583.1\|4270476_4270941_+	HXXEE domain-containing protein	NA	NA	NA	NA
WP_096613159.1\|4270948_4271782_-	hypothetical protein	NA	NA	NA	NA
WP_096613157.1\|4271815_4272199_+	DUF4440 domain-containing protein	NA	NA	NA	NA
WP_096613155.1\|4272380_4272914_+	N-acetyltransferase	NA	NA	NA	NA
WP_096613153.1\|4272958_4273450_+	ATP-binding protein	A0A2H4JFX6	uncultured_Caudovirales_phage	4.0e-45	54.3
WP_096613151.1\|4273649_4274102_+	cupin domain-containing protein	NA	NA	NA	NA
WP_096613149.1\|4274106_4274574_+	N-acetyltransferase	NA	NA	NA	NA
WP_096613147.1\|4275714_4276170_+	N-acetyltransferase	NA	NA	NA	NA
WP_096613145.1\|4276298_4276778_+	N-acetyltransferase	NA	NA	NA	NA
WP_096613143.1\|4276859_4277492_+	Vat family streptogramin A O-acetyltransferase	M1HKK6	Paramecium_bursaria_Chlorella_virus	1.2e-22	38.9
WP_096613141.1\|4277863_4279054_+	MFS transporter	NA	NA	NA	NA
WP_096612700.1\|4280578_4281709_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096613139.1\|4281926_4282145_-	hypothetical protein	NA	NA	NA	NA
WP_096611667.1\|4282570_4284106_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_6

4550257 : 4632338

Bacillus_phage(22.22%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096612791.1\|4550257_4551277_-\|tRNA	tRNA-dihydrouridine synthase family protein	NA	NA	NA	NA
WP_096613549.1\|4551535_4552399_+	carboxyvinyl-carboxyphosphonate phosphorylmutase	NA	NA	NA	NA
WP_096612790.1\|4552955_4554632_+	FAD-binding protein	NA	NA	NA	NA
WP_096612788.1\|4554636_4555308_+	glutathione S-transferase family protein	NA	NA	NA	NA
WP_096612786.1\|4555392_4556631_+	cytochrome P450	NA	NA	NA	NA
WP_096612784.1\|4556900_4558862_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096612782.1\|4558982_4559699_-	pirin family protein	NA	NA	NA	NA
WP_096612780.1\|4559895_4561017_-	sensor histidine kinase KdpD	NA	NA	NA	NA
WP_096613547.1\|4561155_4561728_-	K(+)-transporting ATPase subunit C	NA	NA	NA	NA
WP_096612778.1\|4561979_4562222_-	K(+)-transporting ATPase subunit F	NA	NA	NA	NA
WP_096612776.1\|4562243_4564313_-	K(+)-transporting ATPase subunit B	M1HBF8	Paramecium_bursaria_Chlorella_virus	8.0e-26	26.4
WP_096612774.1\|4564372_4566058_-	potassium-transporting ATPase subunit A	NA	NA	NA	NA
WP_096612772.1\|4566162_4566483_-	potassium transporter TrkA	NA	NA	NA	NA
WP_096612770.1\|4566972_4568085_+	sensor histidine kinase	NA	NA	NA	NA
WP_096612768.1\|4568109_4569648_-	VCBS repeat-containing protein	NA	NA	NA	NA
WP_096609621.1\|4569746_4570907_+\|transposase	transposase	NA	NA	NA	NA
WP_096612766.1\|4570935_4571601_-	hypothetical protein	NA	NA	NA	NA
WP_096612764.1\|4572419_4573112_+	DNA-binding response regulator	NA	NA	NA	NA
WP_096612762.1\|4573112_4573979_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	5.4e-61	45.6
WP_096612760.1\|4574053_4574959_+	sugar kinase	NA	NA	NA	NA
WP_096612758.1\|4575255_4576125_+	3'(2'),5'-bisphosphate nucleotidase CysQ	NA	NA	NA	NA
WP_096612756.1\|4576169_4577249_-	cobalt-precorrin-5B (C(1))-methyltransferase	NA	NA	NA	NA
WP_096612754.1\|4577366_4578155_+	hypothetical protein	NA	NA	NA	NA
WP_096612752.1\|4578484_4581013_-	mannose-1-phosphate guanylyltransferase	I7I009	Enterobacteria_phage	5.2e-11	28.2
WP_096612750.1\|4581472_4583119_+	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_096612748.1\|4583324_4583516_+	hypothetical protein	NA	NA	NA	NA
WP_096612746.1\|4583836_4585150_+	cytochrome P450	I6XF76	Cotesia_sesamiae_Mombasa_bracovirus	4.3e-17	24.4
WP_096612744.1\|4585327_4586254_+	hypothetical protein	NA	NA	NA	NA
WP_096612742.1\|4586283_4587462_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_096612740.1\|4587887_4588940_+	dipeptide epimerase	NA	NA	NA	NA
WP_096612738.1\|4588923_4589967_+	DUF1611 domain-containing protein	NA	NA	NA	NA
WP_096612736.1\|4590118_4592227_-	flavin-dependent dehydrogenase	NA	NA	NA	NA
WP_096612734.1\|4592385_4592619_+	hypothetical protein	NA	NA	NA	NA
WP_096612732.1\|4592637_4592826_+	hypothetical protein	NA	NA	NA	NA
WP_096612730.1\|4593012_4594104_-	HlyD family secretion protein	NA	NA	NA	NA
WP_096612728.1\|4594491_4595451_+	Red carotenoid-binding protein	NA	NA	NA	NA
WP_096613545.1\|4595591_4595921_+	hypothetical protein	NA	NA	NA	NA
WP_096612726.1\|4596048_4597815_-\|protease	subtilisin-like serine protease	A0A2L0UZX3	Agrobacterium_phage	2.1e-06	26.1
WP_096612724.1\|4599447_4599993_-	hypothetical protein	NA	NA	NA	NA
WP_096612722.1\|4600024_4601158_-	aminoglycoside phosphotransferase family protein	NA	NA	NA	NA
WP_096612720.1\|4601396_4602485_-	choice-of-anchor A family protein	NA	NA	NA	NA
WP_096612718.1\|4603131_4604652_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_096613543.1\|4604772_4605348_+	DUF1211 domain-containing protein	NA	NA	NA	NA
WP_096612716.1\|4606037_4607303_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_096612714.1\|4607449_4608889_+	ATPase	W8CYF6	Bacillus_phage	8.3e-22	31.5
WP_096612712.1\|4608940_4609156_-	hypothetical protein	NA	NA	NA	NA
WP_096612710.1\|4609736_4611659_+	serine/threonine protein kinase	A0A075BSL8	Microcystis_phage	9.5e-74	56.4
WP_096612708.1\|4611907_4612330_-	hypothetical protein	NA	NA	NA	NA
WP_096613541.1\|4612702_4613995_-	GHKL domain-containing protein	W8CYM9	Bacillus_phage	1.4e-15	32.5
WP_096612706.1\|4613994_4616769_-	CHASE2 domain-containing protein	Q8QKV7	Ectocarpus_siliculosus_virus	1.7e-47	33.8
WP_096612704.1\|4616894_4617908_-	DUF928 domain-containing protein	NA	NA	NA	NA
WP_096612702.1\|4618099_4620700_-	CHAT domain-containing protein	NA	NA	NA	NA
WP_096612700.1\|4621271_4622402_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_096610164.1\|4623331_4624474_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_096612698.1\|4624718_4626518_+	ShlB/FhaC/HecB family hemolysin secretion/activation protein	NA	NA	NA	NA
WP_096612696.1\|4626578_4628246_+	hypothetical protein	NA	NA	NA	NA
WP_096613183.1\|4628434_4629505_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096613183.1\|4631267_4632338_+\|transposase	IS701 family transposase	NA	NA	NA	NA

DBSCAN-SWA_7

5760241 : 5842576

Bacillus_phage(18.18%)

tail,plate,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096611103.1\|5760241_5761763_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_096611101.1\|5762212_5762464_+	acetyltransferase	NA	NA	NA	NA
WP_096611099.1\|5762722_5764138_+	3-isopropylmalate dehydratase large subunit	NA	NA	NA	NA
WP_096611097.1\|5764279_5764888_+	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_096611095.1\|5765236_5767600_+	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	2.7e-46	32.6
WP_096611093.1\|5767655_5769044_+	hybrid sensor histidine kinase/response regulator	W8CYM9	Bacillus_phage	4.5e-17	37.2
WP_096611091.1\|5769201_5770206_-	glycerophosphodiester phosphodiesterase	NA	NA	NA	NA
WP_096611089.1\|5770330_5771215_-	peptidase M15	NA	NA	NA	NA
WP_096611087.1\|5771561_5773046_+	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_096611085.1\|5773262_5774273_+	MoxR family ATPase	H6WG28	Cyanophage	1.2e-83	46.7
WP_096613370.1\|5774305_5775454_+	hypothetical protein	A0A2I7SAP6	Vibrio_phage	8.0e-28	27.9
WP_096611083.1\|5775900_5776920_+	hypothetical protein	NA	NA	NA	NA
WP_096611081.1\|5777190_5779887_+	hypothetical protein	NA	NA	NA	NA
WP_096611079.1\|5779927_5781055_-	ATP-binding protein	NA	NA	NA	NA
WP_096611077.1\|5781183_5783931_+	carbonate dehydratase	A0A1J0FA34	Only_Syngen_Nebraska_virus	1.3e-68	28.9
WP_096611075.1\|5785489_5786551_+	transcriptional regulator	NA	NA	NA	NA
WP_096611073.1\|5786659_5788213_+	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.4e-20	31.3
WP_096611071.1\|5788209_5789208_+	ribose ABC transporter permease	NA	NA	NA	NA
WP_096611069.1\|5789405_5791019_+	hypothetical protein	Q5GQG9	Synechococcus_phage	1.8e-09	39.1
WP_096611067.1\|5791140_5791560_-	GFA family protein	NA	NA	NA	NA
WP_096611065.1\|5791596_5791968_-	DUF2834 domain-containing protein	NA	NA	NA	NA
WP_096611063.1\|5792075_5792930_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_096610996.1\|5793148_5794072_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_096613368.1\|5794256_5795048_-	TVP38/TMEM64 family protein	NA	NA	NA	NA
WP_096611061.1\|5797081_5797945_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_096611059.1\|5798131_5799550_+	HlyD family secretion protein	NA	NA	NA	NA
WP_096611056.1\|5799719_5800895_+	ABC transporter	NA	NA	NA	NA
WP_096611054.1\|5800942_5801665_+	ABC transporter	G9BWD6	Planktothrix_phage	9.7e-88	75.6
WP_096611052.1\|5801708_5803145_-\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_096611050.1\|5803236_5804556_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_096611048.1\|5804608_5806372_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096611046.1\|5806466_5808971_+	hypothetical protein	NA	NA	NA	NA
WP_096611044.1\|5809062_5809458_-	DUF4280 domain-containing protein	NA	NA	NA	NA
WP_096611042.1\|5809619_5811581_-	type IV secretion protein Rhs	NA	NA	NA	NA
WP_096611040.1\|5811663_5812170_-	hypothetical protein	NA	NA	NA	NA
WP_096611038.1\|5812212_5814888_-	hypothetical protein	NA	NA	NA	NA
WP_096611036.1\|5814891_5815416_-\|tail	phage tail protein	NA	NA	NA	NA
WP_096611034.1\|5815473_5815680_-	hypothetical protein	NA	NA	NA	NA
WP_096611032.1\|5815791_5816157_-	hypothetical protein	NA	NA	NA	NA
WP_096611030.1\|5816176_5816500_-	hypothetical protein	NA	NA	NA	NA
WP_096611028.1\|5816761_5817250_-\|tail	phage tail protein	NA	NA	NA	NA
WP_096611026.1\|5817456_5817930_-\|tail	phage tail protein	NA	NA	NA	NA
WP_096611024.1\|5818036_5818510_-\|tail	phage tail protein	NA	NA	NA	NA
WP_096611022.1\|5818684_5820391_-\|tail	phage tail sheath family protein	A0A127AW39	Bacillus_phage	2.7e-19	29.5
WP_096611020.1\|5821055_5822327_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_096611018.1\|5822462_5822675_+	hypothetical protein	NA	NA	NA	NA
WP_096611016.1\|5822671_5824690_+	ATP-binding protein	K9MCS8	Sulfolobus_virus	1.4e-06	31.4
WP_096611014.1\|5824728_5824938_+	Nif11-like leader peptide family natural product precursor	NA	NA	NA	NA
WP_096611012.1\|5825129_5825810_+	hypothetical protein	NA	NA	NA	NA
WP_096613366.1\|5828892_5829297_-	hypothetical protein	NA	NA	NA	NA
WP_096611010.1\|5830472_5830874_+\|plate	baseplate protein	V5YTB2	Pseudomonas_phage	4.1e-11	48.8
WP_096613364.1\|5830940_5833139_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_096611008.1\|5833207_5834257_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096611006.1\|5834366_5835674_+	hypothetical protein	NA	NA	NA	NA
WP_096611004.1\|5835857_5836952_+	DUF3365 domain-containing protein	NA	NA	NA	NA
WP_096611002.1\|5837038_5838439_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_096611000.1\|5838483_5840721_+	hypothetical protein	NA	NA	NA	NA
WP_096610998.1\|5840804_5841605_+	hypothetical protein	NA	NA	NA	NA
WP_096610996.1\|5841652_5842576_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_AP018274

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP018274_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018274_1

1243991-1244317

Unclear

III-A

Consensus_repeat	Method
CTTGAAATTACCTTTTACCCCGCAAGGGGATTGAAACG	PILER-CR
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CRT
GTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CRISPRCasFinder

4 spacers

cas6

The CRISPR arrays of NZ_AP018274_1

>merge|NZ_AP018274|1|1243991-1244317|PILER-CR,CRT,CRISPRCasFinder
CGTTTTAATCCCCTTGCGGGGTAAAAGGTAATTTCAAGCTAAGTTTTAAATTCAGTTCTTTTTATGCTATTTCGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAGTGAAGATGGTACTTTTTTGCCGCATTTCCAATTTGAGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAGCAGATTGGAACGTTGGGGATATAATCATATCTGACGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAGTTATTGTATATACATTTCAAAAAACCGTGTCATTCGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG

>NZ_AP018274|1|1|1243991-1244317|PILER-CR
CGTTTTAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CTAAGTTTTAAATTCAGTTCTTTTTATGCTATTT
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	TGAAGATGGTACTTTTTTGCCGCATTTCCAATTTG
AGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CAGATTGGAACGTTGGGGATATAATCATATCTGA
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	TTATTGTATATACATTTCAAAAAACCGTGTCATT
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG

>NZ_AP018274|1|1|1243991-1244317|CRT
CGTTTTAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CTAAGTTTTAAATTCAGTTCTTTTTATGCTATTT
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	TGAAGATGGTACTTTTTTGCCGCATTTCCAATTTG
AGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CAGATTGGAACGTTGGGGATATAATCATATCTGA
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	TTATTGTATATACATTTCAAAAAACCGTGTCATT
CGTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG

>NZ_AP018274|1|1|1243992-1244317|CRISPRCasFinder
GTTTTAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CTAAGTTTTAAATTCAGTTCTTTTTATGCTATTTC
GTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	TGAAGATGGTACTTTTTTGCCGCATTTCCAATTTGA
GTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	CAGATTGGAACGTTGGGGATATAATCATATCTGAC
GTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG	TTATTGTATATACATTTCAAAAAACCGTGTCATTC
GTTTCAATCCCCTTGCGGGGTAAAAGGTAATTTCAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018274.1\|WP_096610802.1\|1246769_1247021_-\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|379097
NZ_AP018274.1\|WP_096610818.1\|1257786_1258971_+\|DUF1822-domain-containing-protein	unknown	unknown	gnl\|CDD\|370155
NZ_AP018274.1\|WP_096610792.1\|1240185_1240431_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|226603
NZ_AP018274.1\|WP_096610806.1\|1249556_1250609_+\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380527
NZ_AP018274.1\|WP_096610804.1\|1247300_1249400_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_AP018274.1\|WP_096610786.1\|1235879_1238543_+\|OLD-family-endonuclease	unknown	unknown	gnl\|CDD\|226121
NZ_AP018274.1\|WP_096610808.1\|1250913_1252410_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226364
NZ_AP018274.1\|WP_096610790.1\|1239790_1240189_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NZ_AP018274.1\|WP_096610814.1\|1255019_1256417_+\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|227328
NZ_AP018274.1\|WP_096610816.1\|1256544_1257735_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_AP018274.1\|WP_096610788.1\|1238969_1239434_+\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119345
NZ_AP018274.1\|WP_096610810.1\|1252423_1253467_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226962
NZ_AP018274.1\|WP_096610798.1\|1243180_1243861_-\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_AP018274.1\|WP_096610796.1\|1241353_1242979_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_AP018274.1\|WP_096610784.1\|1234616_1234979_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096610812.1\|1253536_1254472_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224005
NZ_AP018274.1\|WP_096610800.1\|1244595_1245732_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NZ_AP018274.1\|WP_096610794.1\|1240738_1241182_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096610782.1\|1233635_1234547_+\|transporter	unknown	unknown	gnl\|CDD\|130314
NZ_AP018274.1\|WP_096610780.1\|1232447_1233467_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NZ_AP018274.1\|WP_096610802.1\|1246769_1247021_-\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|379097	pfam13275, S4_2, S4 domain. The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	1.82561e-28
NZ_AP018274.1\|WP_096610818.1\|1257786_1258971_+\|DUF1822-domain-containing-protein	gnl\|CDD\|370155	pfam08852, DUF1822, Protein of unknown function (DUF1822). This family of proteins are functionally uncharacterized.	9.80735e-87
NZ_AP018274.1\|WP_096610792.1\|1240185_1240431_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	1.98731e-18
NZ_AP018274.1\|WP_096610780.1\|1232447_1233467_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.09839e-106
NZ_AP018274.1\|WP_096610804.1\|1247300_1249400_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_AP018274.1\|WP_096610786.1\|1235879_1238543_+\|OLD-family-endonuclease	gnl\|CDD\|226121	COG3593, COG3593, Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair].	8.84072e-12
NZ_AP018274.1\|WP_096610808.1\|1250913_1252410_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226364	COG3845, COG3845, ABC-type uncharacterized transport systems, ATPase components [General function prediction only].	0
NZ_AP018274.1\|WP_096610790.1\|1239790_1240189_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.83816e-59
NZ_AP018274.1\|WP_096610816.1\|1256544_1257735_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	8.29159e-10
NZ_AP018274.1\|WP_096610806.1\|1249556_1250609_+\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380527	cd06304, PBP1_BmpA_Med_PnrA-like, periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria. These outer membrane proteins include Med, a cell-surface localized protein regulating the competence transcription factor gene comK in Bacillus subtilis, and PnrA, a periplasmic purine nucleoside binding protein of an ATP-binding cassette (ABC) transport system in Treponema pallidum. All contain the type 1 periplasmic sugar-binding protein-like fold.	4.08058e-103
NZ_AP018274.1\|WP_096610810.1\|1252423_1253467_+\|ABC-transporter-permease	gnl\|CDD\|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.38175e-107
NZ_AP018274.1\|WP_096610798.1\|1243180_1243861_-\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	2.91501e-54
NZ_AP018274.1\|WP_096610796.1\|1241353_1242979_+\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	3.38116e-72
NZ_AP018274.1\|WP_096610812.1\|1253536_1254472_+\|ABC-transporter-permease	gnl\|CDD\|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	1.05795e-105
NZ_AP018274.1\|WP_096610788.1\|1238969_1239434_+\|ASCH-domain-containing-protein	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	1.50866e-62
NZ_AP018274.1\|WP_096610814.1\|1255019_1256417_+\|CHAT-domain-containing-protein	gnl\|CDD\|227328	COG4995, COG4995, Uncharacterized protein conserved in bacteria [Function unknown].	2.04129e-102
NZ_AP018274.1\|WP_096610782.1\|1233635_1234547_+\|transporter	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	2.41586e-26
NZ_AP018274.1\|WP_096610800.1\|1244595_1245732_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.447e-36

>NZ_AP018274.1|WP_096610798.1|1243180_1243861_-|TrkA-family-potassium-uptake-protein
MYVLIGGVGRMGSDLAKTLIHMGHTIAAVDTDAVACQYAREKIGVMAFEGSAVNTTVLLEAGIRKANAVIATLQEDALNLALVTLCKHYGVPQIIVRMSDRDFAEPYQLAGATHIISTTELAINRVINAIEYPQVDAMMHFEQGQIEVLKLSIPQKCSIVGRSVAEIAQDYRFPAGTLIIGYQAHPQENLNIPNGSTILESGSTILAVTKPELVRQLIDFMGLCSP
>NZ_AP018274.1|WP_096610796.1|1241353_1242979_+|sodium:proton-antiporter
MVMNYLPTSEVSNLLLWQSVALPSGEFQGLVNTLIVLLLVATAVALVTRWLRIPYVIGLVLAGLAITKQALSESVGLNPDVILNLFLPILIFEAAINTDISRLRSTIKPIALLAGPGVILSAAITAILLKLGLGLVWITACAVSVILTITDTVSVIAAFRTVPVPGRLATIVEGESLFNDGVAMVLLSIITAVHLQGSFTLGEGIKQVFIAFVGGGVLGLGLGYLCVGLFQQLDDALSSILLTVAVSLGTFQIGQALGVSSAIAVLVAGLVIGNLAFRQSSASIKVTLLSFWEYAGFGVNTFIFLFVGIEVEPNILWATIPSALVAILAYQIGRIFSIYPLLFLLGFVDRPLPIRWQHVLIFGNVKGSLSMALALSLPFSLPGRMQVITLVFSTVLVSLVGQGLSLPWLVKRLQLSKPSSVRQEIEPLQLNLIAAKAAQEELKNLLQSGSLPKFLYEELFASYQARIASSEEKLRNLYNHRIDYELNELEERGYLDGLYRRLYTAEKGAINDAVLKGLLPDEIAKSYVEELNEKLLSLKDD
>NZ_AP018274.1|WP_096610794.1|1240738_1241182_+|hypothetical-protein
MELLFKISFLILSALFAGIVLFLSTVLRETFNALTEERYYSVYSEIIIRGRKSIIINIIVLVPILIFAVYLICGFRNLLFIIGSLLYIFGSFVSSILINEPAYTQLLNMDINDQAGIIRIRGLLNKGNIVRAISSFLGILLVGISIY
>NZ_AP018274.1|WP_096610792.1|1240185_1240431_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
METVNIHQAKTNLSRLLSRVELGEEIVISNRGVPIAKLVPFRTSLDRRSSLGQDRGMFTVPDDFNAPLPEDILVAFEGGAE
>NZ_AP018274.1|WP_096610790.1|1239790_1240189_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MRLLLDTQCWLWWFAQPEKLSENVIEQIADETNEVWLSVASVWEMGIKVSIGKLPLREPINDYVSTRMNQLGARSLEITASHALRVAVLPLHHRDPFDRMLIAQAQVEDMTLVSADLIFKQYEVSLLWAASS
>NZ_AP018274.1|WP_096610788.1|1238969_1239434_+|ASCH-domain-containing-protein
MSQEQLEQYWQAYLASIPNASFSSEDYEADQFGDNSVLANELGNLILRGVKTATCSALWEWEAEGSEIPKVGSKTIVLDGDNNPLCIIETIEVEIRAFSEVDTQFAFEEGEDDRSLESWRREHWEYFSRVLPKIGKQPSREMLLVCERFRVVYK
>NZ_AP018274.1|WP_096610786.1|1235879_1238543_+|OLD-family-endonuclease
MHLKTVFIRFYKSFNDDFLRKNDDRVKPKPWEMVGNTFYPYIEVPIDPKITTVVGANESGKSHLLSAIEKAISGEEIQRSDFCRYSPFFTVRQNELKYPDFGSEWSTPSKTEEGKLRMIAGIPENVRFDRFLIFRKNISELTVYLPEKGDYRPYRIDQTKADDLQDLLPVPLKIESNIALPASVPIKKLAQLGKRIDPNGRKFEVLDRKQRVNIIDALDDFSDHPELFTKVRQPWGEMEPDAVNTIKSIISALEEASFSNAEKEKREKEFELAYKLICNIAQVDVDALVDLADAVKDGMQGYANGIIEKINRQLSINLNFPNYWVQDRNFCLKVMARDYDLVFTITDRTGTEYSFDERSVGLKYFLSYYIQYRSHEPHPHKSEILLMDEPDAYLSSQAQQDLLKIFDLFAYPEPGSHLTRSIQVVYVTHSPFLIDKNHAERIRVLQKGNEDEGTRVVKDAAKNHYEPLRSSIGAYVGETTFIGNCNLMVEGLTDQILIAGATSYLRSIGTANLETLDLNRITIVPSGSASHIPYLVYLARGRDVEQPAVIVLLDSDNSGDDARKQLLGKGGQHRRPLLKEQFILQVGDLKDQFRLIETMTTKLEMEDILPLPICIQATKLYLQEFLQVEETELSFLTEDLVLSNATDQTMLNAIQISLSKFPDKNLVVNKVGFARNVLCVVQQWSQQRKSLQKAESEALQTFEDNFRVLFRQLNGMQRRAQQKLTHEKLSQKIERLKKNFVALHPVSARREDAVILLDEIEGILESNIENEAVKEIEAIKSAIQNLKRDYQLDVDMNNAIHDYIGFQMGLERVKYAGLLASQEETVEIAQVEEAITVADEDAQANKSVDAQIITSTKTLNNASEANTTKITNNPTASDKRKKHNQRS
>NZ_AP018274.1|WP_096610784.1|1234616_1234979_+|hypothetical-protein
MKIRSLGLAIAFGLGLAAVAVPQKSMAQFTNPQNYDQPNANDPFSPGVEQNGFSMFQLLHNAQLGIGSYNPDFANQKRQELDQEAASFFTRQRQRMQQGNVQPNNQSGSPVIKLEPSSGQ
>NZ_AP018274.1|WP_096610782.1|1233635_1234547_+|transporter
MSNTLTPPKSDPKSDINWQQIASPQLYQDAAPANFLGETIQETLALTKRLFIQLQRRPSTLFAGIIQPVMWLVLFGALFQNAPKGIFGSTTNYGQFLAAGVIVFTAFAGALNAGLPIMFDREFGFLNRLLVAPLASRFSIVFASAIFIISQSLLQAAVIVGAAAFLGAGLPDVAGLATIALIVFALALGVTALSLGLAFTLPGHIELIAVIFVSTLPMLFASTALAPLSFMPNWLQVIATINPLSYAIEPIRYLYTHSNWGLNSIVMRSFWGDVSFGGALLVLVGFAAVALISIQPRLRKTLS
>NZ_AP018274.1|WP_096610780.1|1232447_1233467_+|ABC-transporter-ATP-binding-protein
MAAAVSIQNLKKRYGTVEAVKDVSFEIEPGEIFGLLGPNGAGKTTTLRALCTLTTPDAGKVEVSGISVVENPKAARQRLGYVAQEVALDKILTGREMLQLQAALYHLPAAVTKQRINTVIELLGLQEYADKKTGTYSGGIRKRLDLAAGLLHAPDVLVLDEPTVGLDIESRFIVWEFLRKLREAGTTVLITSHYLEEVDALADRVAIIDRGVVIAAGTPSELKDRVGGDRVTLRIREFSPPEEAEKAKDLLKSLSFVQEVIINSAQGNSLNLVVTPQNDTLITIQQALNNAGLPMFGIAQSRPSLDDVYLAATGRTLMDAEMAAVANRDPKAEKKQNMR
>NZ_AP018274.1|WP_096610800.1|1244595_1245732_-|CRISPR-associated-endoribonuclease-Cas6
MPRSPTPKKKPTTTRTRSKSSLSWADDSEIIGLEFELFTPVNASIYPQYSIGLHAWFLNCVRAVDPDLSAYLHDGESEKPFTISLLDGEIVSSGMNIQLSSDRIYRWYVTGLSSRVTRWMQNWVDNLPTHIELSNIPLKIQSCRIAYPATTYSQLLNKENIGGSVCLNFLSPTSFRRKKHHFPLPVPFNLFQSYLRRWHDFSNFPVETNDFLAWIDEQVIINSHQIASQKVLAGKKGAVTGFTGSIELSLARTAIQNPEYYRLFYALTNFAPYCGTGHKTTFGLGQTRLGWSSKQVQHVPDVASVIATRIEDLTEIFTNQRKRQGGERASEIATKWATILARREMGDSLIAISQDMGIPYETAKTYVKLARKALKEES
>NZ_AP018274.1|WP_096610802.1|1246769_1247021_-|RNA-binding-S4-domain-containing-protein
MKPRDNTIKLNQFLKLMGIVPTGGQAKLMIQGGEVLVNGVLETRRGRKLVPGDKVTLEGQTFEVNLNNNQDSNTFLNSSQENE
>NZ_AP018274.1|WP_096610804.1|1247300_1249400_+|hydantoinase/oxoprolinase-family-protein
MLKVFADRGGTFTDIVAVTDSQLIIDRLLKHPQRFLIVSLGDRQWVIVYKLLSENPEQYQDAAIQGIRDILGLTSNQPIPTTEIEVVKMGTTVATNALLERKGDRVVLVITKGFKDALRIGYQNRPNIFARQIILPTMLYEQVVEVDERYDAQGNELIPVNIEQVKKDLEAAYNLGIRSCAIIFMHSYNYPQHEEIVAEIAQQVGFSQISISHQVSPLMKLVSRGDTTVVDAYLTPILQRYINQVANQLPDVKLMFMKSDGGLVAAAQFQGKDSILSGPAGGIVGAVQTSKRAGFELVITFDMGGTSTDVAHFKGEYERQLDSEIAGARMRVPVLDIHTIAAGGGSILFFDGSSYRVGPESAGSNPGPASYRRGGKLAVTDANIMLGKIHPQYFPSVFGIDGNLPLDKEVVNEQFQQLATGNSRTPEEVAAGFIAIAVENMANAIKKISLQRGYDVTEYVLCCFGGAGAQVACLIADTLGMRNIFLHPYAGVLSAYGMGLADVRTMRELGVEKELTKELIPQLQQLIQGLEIQVRNGEDIDIDLPEEIRKTREELVKKVNLKYEGSNSTLTVDFSVDILTMQQEFTELHKNRYGFIQSEKSLIVESISVEFIQKMDTPEEPLLSRMRPVDEMPIPVEIVKIFTANKWHEAPVYQREDLQPGDKIKGSAIIVEKISTIVVEPNWEARLTHHNHLILERID
>NZ_AP018274.1|WP_096610806.1|1249556_1250609_+|BMP-family-ABC-transporter-substrate-binding-protein
MAGNFGRRKFIVYASSAVGGSLLLKGCTNNQTTPANTSSNNNFKIAIALPGVISDKAWNQSGYEGIQLAKQKLGVEIAHVEKVAQPDQAEVLSDFARRGYNLVFAHGGQFDAAIQQIASQFPNTFFVGVNGNVSGANIASLRLEHLQASYLCGIIAAGMTKSNKLAYIAGQEFQATQEELRGFELGAKSIKKDIQVNSTFTGDWNDVAKAKEATLALISTGVDVIYQWLDSASATVLQTAGDKNIYAFGNTIDQLEIAPKSVLTSAVKHLDAAILYLTDLAKQKQIQGKIYKLGLERADILALGKFNQLIPAAIQKQVLTSKEEIIAKKVIFEDCKDAGKDTFCIKKNTV
>NZ_AP018274.1|WP_096610808.1|1250913_1252410_+|ABC-transporter-ATP-binding-protein
MSYLRLENITKKFGDFIANDNINLNIETGTTHAILGENGAGKSTLMNIISGLYQPDSGQIFIDDIPVKITSPAIGIQLGIGMIHQHFMLVPELTVTENIILGTGNNLHLNLDNKQAEIAQLSQSYNLEIDPSAKVKNLPVGMQQRVEILKVLYRQAKLLILDEPTAVLTPPEVRSLINILRQLAAKGHTIIFISHKLAEVMNLCDRITVLRRGKVVANTTKESATPQQLADLMISRTVNLQVNKKSTSPGAVVLSVQNLQVADDRGVIAVKNISFELHQGEILGVAGVDGNGQRELADAICGLRKVKQGKIYPSPNPSPLFVKTKSLRVGYIPEDRQKNGLVMEFDISQNLILKLFKNLPFSRYGLLRRKAINHHAISTITEFDIRANGVNILTKQLSGGNQQKIILARELAGEPELIVAMQPTRGLDVGATEAVQQRLLTEKQRGTAIVYISTELEEIMTMCDRIAVIYQGEFVGIFDASMATSEEIGLLMSGAKIS
>NZ_AP018274.1|WP_096610810.1|1252423_1253467_+|ABC-transporter-permease
MTTTIRKLVIPIISPLIAIFSALLVGAILMMIAGANPIIAYTALFQESLLSYFGFGNTLTKMTPLLFTSLGVLIALKAGQYNIGGEGQIYLGALGSTLIGLYLKNLPPFIHIPLALCAGFIFGGIWGLIPGYLKAIRGVNEVITTLLLNYIAIHLISYLVQNPLKELNAPSPYSPLIAKSAQLPIILSGSLVHAGILISTIAAVILWIIINHSTLGYQIKAVGFNPNASRYAGISVQMIIIQVMTFAGGLAGLAGSCEVMGLKYRLFDVVSPGYGFDAIAIAFLSRGNVIGVVLASLFFGALRSGANVMQRSAGVPVTVVYAIQGLTVLFIAISLALEYQVKKESPI
>NZ_AP018274.1|WP_096610812.1|1253536_1254472_+|ABC-transporter-permease
MNIAFLSDYFASTIHLTIPLAYAALGGLYSERSGILNIALEGMLITGAFTSAAATFYTGNIWIGLIATLIAGALIGLLHAFLCVTLRVNQLVSGLAINLVAAGVTAFLGRLVFANNSTQRLPNLSAIKIPIFANIPIIGNLLFQQDILVYLLFIIIALTTYFLFYTNPGLNLRAVGEYPQAADTAGVSVVKIRYMAVIFGGCLASLGGAYLTLVQVRYFTEEMSAGKGFIAIASLIFGKWHPIYSSLACLLFAATEALQLRIQALGINIPYQFLMMLPYITALLALIGLAGKSTPPAALGISYGSRKQNLR
>NZ_AP018274.1|WP_096610814.1|1255019_1256417_+|CHAT-domain-containing-protein
MNKTKLTLLAFSALSLSIIGLYGLKISRESLNSFNAVSPATKSITLPASRLQPEVLTKLLDNKDINSAIIHVEQGWKQQYDEYAQGKLPSNRMIEVREISRILEQIHQQNGTKSALIYAVPTPKHLELILVTPGKSPIHKRITKAKRDIVVSLVSKFRKDIVNPNSQRSDYLSSGKQVYDLLISPLESELQAQGINNLIFCLGGGLRTVPLAAISDGKQFLVEKYSLGIIPAFNLLDLQPANITQTQVLAMGASEFKNKEPLPAVPLELSSITSNKWQGKSLLNKEFTLQNLKKQRALYPFGIVHLATHAEFSPGSVQQSYIQFWDAQVRLDEIKSLGLDEPLVKLLVLSACRTALGDAKAELGFAGFAVMSRAQAVIASLWSVDDGGTLALMTQFYQQLKANPMKAEALRQTQIAMLKQQVSLKNNPALRGNNSLPAEVVANLDNRELSHPYYWAGFTLIGNPW
>NZ_AP018274.1|WP_096610816.1|1256544_1257735_+|sigma-70-family-RNA-polymerase-sigma-factor
MRARQNLVELFSTFLQFESNRFSGWVTDAKLYRSIKACLNNFSEAKVNEDFWAVYWHKQTQKSEKPEVALGHMSAYLQEPCYWTVQKMMLRSQQSYDKMPDLFQVAIASVPKILKSCNPDVSGSVKAYASIAFGNIIRDYLKQTKEANFCNNWALLLKTSRKLLTESLQNAGFDAATRERYLLAWTCFESIYLPRKDTRLRQTAAPDSETWQAIAAAYNHMRHQLASPGGECSKENMERWLIECGNQVRKYLYPPVKSLNAPKPGYEEGELQDELVDNFQESLLTEWIQEEEKAARLEQKKQINNILTEAIAKLDATSQQLLQLYYQKTLTQQQIAQELAIQQYTVSRRLSKTRESLLLTLTRWSQQTLHISVTSDVVKYISTVLEEWLQAHYHRE
>NZ_AP018274.1|WP_096610818.1|1257786_1258971_+|DUF1822-domain-containing-protein
MTFLTENLTQLEFQISPDLAQQSWLKSQLQSTAKGQWNAYLNQISLQILLPWLQTEYEQQTSLVFNEKLLSSFWDVVNGTAINWGHKRLIIIPEKSLDNSEYSIPQEWIDVPKLVGDYYLAVQINPDELSMRVWGYTTHEQIKVSGRYNSTDRTYSLDTEEIITDLNVLWVVSQLNPEEKTCAPVASLSPVPAIQAENLLSRLTNPNIIQPRLELPFALWGDLVSNDDWRQKLYQLRQGEVSTNLSPRQVAANISQWLQNTFEESWQSLDNLLGTNASLGFSFRKAAEESDATIKRAKSLNLPNAEVILIMGLDTETDDRIGIRIQLRSRSQEEYLPAAINLKLLSASGNIIQSIQSRSQDNIIQLKRFKSPVGTQFSVQVEVDNFVVTENFTI

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Crispr_ID: NZ_AP018274_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018274_2

1437187-1437269

Orphan

Consensus_repeat	Method
TTATCCCCCTCCCACTGCGCTTCTAATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018274_2

>merge|NZ_AP018274|2|1437187-1437269|CRISPRCasFinder
TTATCCCCCTCCCACTGCGCTTCTAATCTTGCTAAAGTAGCCTTCTGTGCAGATTTATCACCCTCCCACTGCGCTTCTAATCT

>NZ_AP018274|2|2|1437187-1437269|CRISPRCasFinder
TTATCCCCCTCCCACTGCGCTTCTAATCT	TGCTAAAGTAGCCTTCTGTGCAGAT
TTATCACCCTCCCACTGCGCTTCTAATCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018274.1\|WP_096611073.1\|1447703_1449257_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_AP018274.1\|WP_096611052.1\|1432771_1434208_+\|IS66-family-transposase	unknown	unknown	gnl\|CDD\|376980
NZ_AP018274.1\|WP_096610996.1\|1441844_1442768_-\|IS5/IS1182-family-transposase	unknown	unknown	gnl\|CDD\|372577
NZ_AP018274.1\|WP_096611050.1\|1431360_1432680_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_AP018274.1\|WP_096611069.1\|1444897_1446511_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|335962
NZ_AP018274.1\|WP_096611065.1\|1443948_1444320_+\|DUF2834-domain-containing-protein	unknown	unknown	gnl\|CDD\|371414
NZ_AP018274.1\|WP_096611048.1\|1429544_1431308_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_AP018274.1\|WP_096611038.1\|1421028_1423704_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096611042.1\|1424335_1426297_+\|type-IV-secretion-protein-Rhs	unknown	unknown	gnl\|CDD\|226032
NZ_AP018274.1\|WP_096611075.1\|1449365_1450427_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|380544
NZ_AP018274.1\|WP_096611067.1\|1444356_1444776_+\|GFA-family-protein	unknown	unknown	gnl\|CDD\|226314
NZ_AP018274.1\|WP_096611063.1\|1442986_1443841_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319
NZ_AP018274.1\|WP_096613368.1\|1440868_1441660_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_AP018274.1\|WP_096611061.1\|1437971_1438835_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP018274.1\|WP_096611054.1\|1434251_1434974_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|274374
NZ_AP018274.1\|WP_096611046.1\|1426945_1429450_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270284
NZ_AP018274.1\|WP_096611044.1\|1426458_1426854_+\|DUF4280-domain-containing-protein	unknown	unknown	gnl\|CDD\|379472
NZ_AP018274.1\|WP_096611071.1\|1446708_1447707_-\|ribose-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226633
NZ_AP018274.1\|WP_096611040.1\|1423746_1424253_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096611056.1\|1435021_1436197_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|130253

Protein	Function_ID	Function_description	E-value
NZ_AP018274.1\|WP_096611073.1\|1447703_1449257_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_AP018274.1\|WP_096611052.1\|1432771_1434208_+\|IS66-family-transposase	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	1.65305e-41
NZ_AP018274.1\|WP_096611075.1\|1449365_1450427_-\|transcriptional-regulator	gnl\|CDD\|380544	cd06321, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. This group includes the periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consist of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	2.58036e-120
NZ_AP018274.1\|WP_096611050.1\|1431360_1432680_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.49123e-32
NZ_AP018274.1\|WP_096611069.1\|1444897_1446511_-\|hypothetical-protein	gnl\|CDD\|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	1.12177e-20
NZ_AP018274.1\|WP_096611065.1\|1443948_1444320_+\|DUF2834-domain-containing-protein	gnl\|CDD\|371414	pfam11196, DUF2834, Protein of unknown function (DUF2834). This is a bacterial family of uncharacterized proteins.	2.01849e-22
NZ_AP018274.1\|WP_096611048.1\|1429544_1431308_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	8.04629e-31
NZ_AP018274.1\|WP_096611071.1\|1446708_1447707_-\|ribose-ABC-transporter-permease	gnl\|CDD\|226633	COG4158, COG4158, Predicted ABC-type sugar transport system, permease component [General function prediction only].	1.75793e-133
NZ_AP018274.1\|WP_096611042.1\|1424335_1426297_+\|type-IV-secretion-protein-Rhs	gnl\|CDD\|226032	COG3501, VgrG, Uncharacterized protein conserved in bacteria [Function unknown].	1.70571e-23
NZ_AP018274.1\|WP_096611067.1\|1444356_1444776_+\|GFA-family-protein	gnl\|CDD\|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	7.0693e-33
NZ_AP018274.1\|WP_096611063.1\|1442986_1443841_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.19325e-31
NZ_AP018274.1\|WP_096613368.1\|1440868_1441660_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	2.311e-44
NZ_AP018274.1\|WP_096611046.1\|1426945_1429450_-\|hypothetical-protein	gnl\|CDD\|270284	cd13566, PBP2_phosphate, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.65913e-11
NZ_AP018274.1\|WP_096611061.1\|1437971_1438835_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.08405e-16
NZ_AP018274.1\|WP_096610996.1\|1441844_1442768_-\|IS5/IS1182-family-transposase	gnl\|CDD\|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.48747e-29
NZ_AP018274.1\|WP_096611044.1\|1426458_1426854_+\|DUF4280-domain-containing-protein	gnl\|CDD\|379472	pfam14107, DUF4280, Domain of unknown function (DUF4280). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 129 and 456 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.28392e-40
NZ_AP018274.1\|WP_096611054.1\|1434251_1434974_-\|ABC-transporter	gnl\|CDD\|274374	TIGR02982, heterocyst_DevA, ABC exporter ATP-binding subunit, DevA family. Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. Cyanobacterial examples are involved in heterocyst formation, by which some fraction of members of the colony undergo a developmental change and become capable of nitrogen fixation. The DevBCA proteins are thought export of either heterocyst-specific glycolipids or an enzyme essential for formation of the laminated layer found in heterocysts.	2.83671e-146
NZ_AP018274.1\|WP_096611056.1\|1435021_1436197_-\|ABC-transporter	gnl\|CDD\|130253	TIGR01185, membrane_spanning_subunit, DevC protein. This model describes a predicted membrane subunit, DevC, of an ABC transporter known so far from two species of cyanobacteria. Some experimental data from mutational analysis suggest that this protein along with DevA and DevB encoded in the same operon may be involved in the transport/export of glycolipids. [Transport and binding proteins, Other].	1.25216e-139

>NZ_AP018274.1|WP_096611056.1|1435021_1436197_-|ABC-transporter
MLKFIQELQRRTPLGWLQLKLHKGRFIVALSGIAFADILMFMQLGFQSALFDSNTRLNRDILADIVLISSQAKNTPNISTFPRSRLFDASDVPGVKAAEPMYIGMVTWKNPQTRKKVKVQAIGFNPEIPALNIPEANAQLDKIKLPDNFLFDRRARGDYSQVFAQIEAGKDVSTEIGKRTITVNGLFSFGASFAADAIILSSEDNFLRLFPQQKASSVNVGLIYIQPGYDPTQVATALKAHLQSDVKVLTRAEFAKFEEDVLRQESPIAFIFDFGVAMGFFIGVIIVYQILSTDVSSHLQEYATFKAMGYGNSYLLGVIFEEAIIIAAIGFIPGYIIPLGLYQLAASATNLPIYMTLARAIFVFVLTLIICIISGAIATQKLQSADPADMF
>NZ_AP018274.1|WP_096611054.1|1434251_1434974_-|ABC-transporter
MSNKSHFEPVISVNNLNHYFGKGQLRKQVLFNINLEIKTGEIIIMTGPSGSGKTTLLTLAGGLRSAQEGSLKVLGKELCGANDKQLTEARRGNGYIFQAHNLHGSLTALQNVRMGLEVHKTFSTTEMMTRSQEMLEFVGLGNRVNYYPDDLSGGQKQRVAIARALVGQPKIVLADEPTAALDKKSGRDVVELMQKLAKEQGCTILLVTHDNRILDIADRIIYMEDGYLRNNDAVGVMSQH
>NZ_AP018274.1|WP_096611052.1|1432771_1434208_+|IS66-family-transposase
MSQKMPAIQRDEELYQLPKEELVKIIQALRIELERLKEIVNKDSKSSSKPPSQDIIKKSEKKKSEQQDSEEGEKRKPGGQPGHEGKTRKGFGRVDRIEMLRPEKCPYCGGIHFLELADKIEKQVVAQFVANPIEIVEYQRIHQQCSHCGTVSAADWSDSIVPGQDLGLRLQALIGWLGNYAHMPYEKIRELIEELGQIDIGEGTLVATNQRVAQAIEKPVKELSDWVKSEQPNIHVDETPWTVKGVKEWLWVFANRGFCLFKAADTRSRDELESILGSEYAGVLSSDDFSVYNGYAANAQQKCLAHMRRHFKNLSKSPVLHNHEIALCFIELIDDVFKNYQQFQITGSLEAYKQWAFDFKSTINKAFKEWIPQAGATALNLLTKLRDKYDQWWYCLDHPEVPPDNNLAERNLRLAVTKRKISGGSRSLERFGDTANLLTVVQTCRSQGRSVIGFFANAILAHTHNQIIFPSLIPCSAT
>NZ_AP018274.1|WP_096611050.1|1431360_1432680_+|pentapeptide-repeat-containing-protein
MKSLLLSLIISSLLVSTAEAAKTSHILKLKETRQCAECDLEDANLKQAFLQKANLRTANLKDANLNGADLRGAFLQKADLRGADLRNAKLEDANLEGAKLDGAMLKNTVISDRTVIERKWLEVFRLVNTQVSNPDLSGVDLAGANLNGLDLRNHNLEGANLQNATLEQALLSGANFNRANLQETSFFISDLRNTSFREANLKKGSLQATDLRGANLSHTNLSRTNLSSAYLEGANVSNSNLDNANLASSILRETDLSQAQLRNANLFTADLRKADLSGVNLRGANLRGADLTQTELENGILGGTKLDGAILREMKLNGANLSRLNLSNVDFNGVNLSNANLRGTNLSGANLSQAILDGANLEGANLSGANLHKAILDSANLLEANLSKANLSEANLNKANITRANLSEANLQRTILSGIRLEFANFCGAIMPNGSKGKC
>NZ_AP018274.1|WP_096611048.1|1429544_1431308_-|tetratricopeptide-repeat-protein
MKITSIHNLQKLANIASISLIFLVANKTKSSAFILNTSTPYLIAQKGLEDDLKDPNYWSNLCNLQLQSKKYEEALTACEQAITLRPKNPILWADHSGVLLKMKKYPEAIASAERALKFDKKTSLALTYQCMAFAELGRHEEGLDNCNQALKVDGNWGKQSPKLAWLHRGVILTNLGQFDQAAIAYDRTLLLEPKDSLALAYRCELMNKIGQPQQAITNCNDALAGNGDWGEKSQTFAYANRAIAYRQQNQLQKAIADYDQLLAIDPNDAIAWTAQGIVLEQLSRFTEALTSFDRAIAINPKYSLAQVGRCGMLNRNKMYEPAQAACDEAIKGNGQWGEIGAAQAWSEIAHALSGQQQYEKALAAANRAVGIKPDYAEAWSNRSVALWQLQQYPEALASSQKAIELKPNYAQAYFNQGTILTKQEQYKAALNSYIKALSLDPKNPKGWANISVVLWHLKQYQPALTAADRAIAIKRDSFEAWYNRGLVLTSLSRHKDALKSYNSAIKINPKSADAFTGRGIILSKLKYYPQAIAALQEALKLNPQQVVAKATLKVVMKEQASQIEEKGKKQGEKGKGERGKCGEREKC
>NZ_AP018274.1|WP_096611046.1|1426945_1429450_-|hypothetical-protein
MKIQKVPQVILKPFVKNYLNQYSRILKHTKYNALMRWSWMQPILEELKGELFADETETVAETAKIITPPPDLPREAGVQFFDSPYQRYACICNDPLRCDRALPITQTGDKTQACTSCGFPALLAEPVLIPNLPEPKQQKIAGLRGVYRIERWLGRLGMGRIYAATQLGINQPVIIKEYLLPGRYFNAEEIHKQLQLFKSVAGICLADGRVQDFRFLQPIEAIIDELQGRCYLVMDERYACPTLNNYLANYRGRKEREKGEGEIRVRGNKENKKNQGMSSSQVHLVLNQTLQTLEFLHGQKFRFPSAQIQNGVVHGNINLDSLLMVKSNQNGYEQSLKVIDEDTIIGSLIVEDLDFFIYLCDLAIWERIFIPISETSVKNNFKDKLENADKPQDLISLGYIAFYLLLGKVISDAGYALDPENETHWGNINPHLKKFIRRLIKGEFLSAEVARQELLKLPKAAFEVPIELSAEAETETPTKFPRLLIFLLTTLGLGVVGGLAWLFFAKPQLSNANSNTPQLNLIKEVGAIPTGNFTYTASKNGIWDYIIQQPDLIQKGQTLEQRLTIAQPKLQLNYQPTTSTEEAIAQVQSGKSAFAIVPLIQPLPADLQAQPIAYDGIGVFVAFSYSQRQKGLPEKLNGQITVEKLRQLYAGNISNWQELGGPNLAVNIYAPVDQEVRQVFTQQILKAKNSPIKSKEDSLQTSQELQEFEMMRTVLRDFESQQAGGIGFGSLSKIVGQCSVYPLALQIEGQPPIQPVILSNNQSIEPNTDLCDRKGSYHPNSELFRTGRYPGAYAIAVVYPIDNNRPPIGEKFAQLLKTKEGQRLLKLTGLVPLE
>NZ_AP018274.1|WP_096611044.1|1426458_1426854_+|DUF4280-domain-containing-protein
MPQQVVMGATLQCVPFGVAPSSLIVIPKGSPVLASGMLAATVMDFAPIANIPPFGMCNSLANPTVAAATAAALGVLTPMPCLPVILGPWKPGAIKTQINKMPALPSTAICNCAWGGVIKIAFPGQIKVSVN
>NZ_AP018274.1|WP_096611042.1|1424335_1426297_+|type-IV-secretion-protein-Rhs
MPASYTATPILKIDGKDASANLLDDILQISVEESLHLPGMFTLMIRNDYYGSRSGENPWMHDNTFAIGKSIEIGFVSSTTADSSFSTPGKSTLIKGEITAIEAQFNSESQAPILVRGYDISHRLHRGRYNRSFQNMTDTDIVKNIIGEVGITAGTIDNTGGPYGFGDPVGYTFQENQTNMEFLRERAARNGFELFVQDGKLYFRKPVAGGSLSLKWLKDITHFHVRVSSAEQVSAVQVRGWDYQKKEAIVSNQTSQNAQVVTSINQGKGEDSIHEFNKNPTMIVVDRPISSQKESDAIAQSIFNELSGEFVQADAKAEGNPAIRPGKVVTLQDMGKYSGKYYITETRHLFQARVYSTEFSVRGLREDSLANFISPQARLQPGQTLMIGIVSNNKDPKKWGRVKVKFPTLTDKHESDWARVVSVGAGNNRGFDCLPEVNDEVLVGFEHGDIHRPFVIGGVWNGKDAPPATVDDAVVDGKVRLRTLKTRTGHTLQFVEEDKGDSKKGVYLNTVYGHKLHLNDSDKLIDIKTKDNYQVTLDDQNKKILIKTNTGYICELNDQSQKITLKASSQEIVMKASGQIDINAQQNITLKVGGNKIEISPTNIKLTAGTSSIDLSPSGATVKSSAMTQVEGSMTTIKGNGTVTVSAPMVSIG
>NZ_AP018274.1|WP_096611040.1|1423746_1424253_+|hypothetical-protein
MSLTKAKLVSSDGGGTIEFMFNPTQLKFSQRISLNKNEGARTGRGLPKVNFAHPQPCTLSIGDIILDTYEEGSNKSVLPYIKQFEKAVNFLEQGSEKDKRPPTYVFTWGNYQYIRCFVTDLAYTLTMFLPDGTPVRAKLDLTLEEIDESTSQPGMSTPSNPDRLGGGR
>NZ_AP018274.1|WP_096611038.1|1421028_1423704_+|hypothetical-protein
MAESNNLPVTNNSNFEESFSAEPLGIKNTLLPSQTLGEKGINPQFLVPLGVQSISVLDTNLLSPKYIEYDFSSSLFEDSPFFSEYINQSQVDTDSQINSSLALAPQFQGQSIQAKSEISYSSEKISSSENVTQSAENQIQPSLINQDITDSPQIKLKQYSTEDVVRSHFNQTAENPVQPSLINPNITDSPHIQLKQDSTENVVRAHFNQTTENQVQASSINPDINDSPQIQLKQDSTEPVVRSQFNQTTENQVQTSSINTEITDSPQIQLKQDSTEDFVRSHFNQTIENQVQTSSINPDINDSPQIQLKQDSTENVVHSGFNQTPENQIQASSINSDITDYVQKKLNKIAENLIQPSLINTEITDSPHIQLKQDSTENVVRSHFSQTPENQIQPPSINPDIIDYPEIQFKQDSTEDVKRSHFNQTAENQVQASSINTEITDSPQIQLNQDVTENVVRSQFNQTIENRIQPSLINTEITDSPHIQLKQDSTENVVRAHFNQTTENQVQASSINPDINDSPQIQLKQDLTENVVRAHFNQTTENQVQASSINPDINDSPQIQLKQDLTENVERSHFNQTAESPVQTSLINTDITDSPQIQLKQDSTANFERSHFNQTPENQVQTSSINPDVTIFPEIQLKQDSTELFVRSHFNQTIENQVQTSSINPDITDSPQIQLKQDSTELFVRSHFNQTLENQVQPSSINTDINSKESNIHPYEINDLPQVLQKITILDPITPRKSINESQQNIDVMTTNINRKTSNINNQISALQPKLEATQIFSSISNKNSSSNSSQWSDFNSLVRGQTTPSKRRSNSTSDNNPTNTSIQAKMSDNLEPIRISRKQDFHSENENSISDNVSKNELEIVAQAIYQQLKQRIRVEFERHGQGYLGRLPW
>NZ_AP018274.1|WP_096611061.1|1437971_1438835_+|TetR/AcrR-family-transcriptional-regulator
MQPKKRSVEKLNIDSTRSPDKIEAILQGAMQEFLTHGFAATSMDRVTAAAGVSKTTVYSYFQDKEKLFIALIEHLITTCGDVLNQQNPEFFQGEPKEVLAGLANHFLNQLSQNVNDKPEFLDLIRLMIAESGRFPMLAQHMVRNTDKNFLQIVTQYLRSHPELQLTDPEATTRVFLGTLVHFVMVEYMLQAGEIIPMERQRLIDCLVNLITGKQTTDKKKYSAIKDKSSRRKRSISGKFERDYTEPKQLRSLRLTDTAWENLDAIAQKNNLTRTELIELFARGVKFD
>NZ_AP018274.1|WP_096613368.1|1440868_1441660_+|TVP38/TMEM64-family-protein
MINFIVSQHQNNVIADISTKNWQKLLRLATLMVMAFGIALIFTVKPAFGQEVAQNAQDFHPQTWLKNALQWVEGLGSVGALAFILLYILASVAFLPGSILTLGAGVVFGVVMGSLYVFIGATIGATVAFLIGRYLARGWVAKKIAENDKFRAIDKAVAREGIKIVLLTRLSPIFPFNLLNYAYGVTGVSLKDYVFGSIGMIPGTIMYVYIGSLAGSIATIGTESQPGNPAVQWAIRIIGFIATVAVTIYVTKVARKALEDEVL
>NZ_AP018274.1|WP_096610996.1|1441844_1442768_-|IS5/IS1182-family-transposase
MSDILNYIEEHPQETKRLIGLNYTELENLIKNAEILHNEKQVLLENKKVRLIEKGGGRQPILSTKEQVILTLVYLRHLMTFQVIGIQFGVSESTANSTFHYWLPLLRDLLPSSLLEQVKKNDTDYETVQEILTDYELIIDSYEQVRERPGHNKEQEKYYSGKACKHTFKTQMAILPNSRDIVDVVAGEPGPKHDITLFRENRDNFHPKQRFKGDLAYQGEDLIDTPIKKPKNGKLTVEQKQQNKKFSSKRVLVEHRIRSVKIFRVVQERFRLKPQKYEQVILTVCGLVRLRIKALILPNVINLSASG
>NZ_AP018274.1|WP_096611063.1|1442986_1443841_-|XRE-family-transcriptional-regulator
MKQPLTVANSNLNQSFGTLLKQWRNQRGFSQLDLAVMSQVSQRHISFLESGRAKPSREMVLQLATVLEIPLRQQNLMLTTAGFAPIHTETDIMAPEMTSIRRAIDFMLQKHEPLPAIVVDRYWNLILANNAGTRLLTTFIDADKLQRTFYVDGKINLMRVVFHSQGLRPFIVSWEDFARHLLQRLHREALAEGESELSTALLKELMSYPGVSEIWHTSNQTPNQTPQNSLLLSIHLKKNDLELQFFSTIATLGTPYDITLQELRIECLFPADEATEHNWQQLVK
>NZ_AP018274.1|WP_096611065.1|1443948_1444320_+|DUF2834-domain-containing-protein
MLQSTNISTKNSFNSIKTFYLLLAIAGSITPWFWLLQDTTALLSPALFLQRAFENNVAADITSDLLISAIAFLGFAWVELKRLGTSRLWAIVYIGLTLGIGLSCALPCFLYHREQMIEGNILR
>NZ_AP018274.1|WP_096611067.1|1444356_1444776_+|GFA-family-protein
MKIPFTGGCMCGNVRYECTAEPIVMGNCHCRDCQRATGTAFAAAMLVPLNAVTVTGDVKYFDVIGDSGSIVGRGFCPNCGSRLFSKPPMPGLMGIMAGSLDEPSEFQPGIDVYTASAQPWDCMNPDLPKFDKMPPSSNV
>NZ_AP018274.1|WP_096611069.1|1444897_1446511_-|hypothetical-protein
MLKYLLSSFPLLLLASPAVWAAPLDNSAAADMKVNTLQGQVTSVSQFSDVQPTDWAFQALQSLVERYGCIAGYPNATYRGNRALTRYEFAAGLNACLDRINELLATATSDLVKKEDLAVLQKLQTDFATELATLRGRVDNLEARTTTLEQQQFSTTTKLNAQIITAVSDTFGNQVGGTDDETNLFFATRGRLNLESSFTGKDLLRVRLEFGNFANANGSSQIAAATGTGMTRLNFDNDSNNKLFVPHVRYYFPVSDSLSFVVGSTGIGYNDITDNITPATIADDGNGIPSLFGKNSLLFERGGGGAAANWKITEDLILTLGYLANTPNNSTAKNGLFDGGYNALAHLAYYGKQGAIGVAYSHGYNPGGTVDITAGRGSALSSAPFGNSIATSNSIVGVQGYYRFSPNFQVHGWGGYIWATAKNSGLSDIANGRGGTDSLFVNSADNANACFGAIGMSFPDVGGKGNLPGILFGLPPRVSHSDVREEGDSSYHIEAFYRWRLNDNISVTPGFWMILNPENDSSNDTQYVGVVRTTFDF
>NZ_AP018274.1|WP_096611071.1|1446708_1447707_-|ribose-ABC-transporter-permease
MSQTLRPVNNRPSQNSAASRRKSINNFLQVAGILPILVIICILFSLLSPNFFTAGNAVNILRQASINIVLATGMTFVILTGGIDLSVGSILAVSAVVAVLVSLLPALGWFAVPAALLTGLLLGLLNGALITFMDVPPFIVTLGSLTALRGAAFLVANGTTVINRNINFAWVGNSYVGPVPWLVIIALLTVAVSWFVLRQTVLGVQIYAVGGNERAARLTGIKVNRVLLFVYGVSGLLAGLAGIMSASRLYSATGILGQGYELDAIAAVILGGTSFTGGIGTIGGTLLGALIIAVLNNGLTLLNMSYFWQLVVKGLVIIAAVMIDRLRRRSRR
>NZ_AP018274.1|WP_096611073.1|1447703_1449257_-|sugar-ABC-transporter-ATP-binding-protein
MTTNIKTDFSPAATATPVLEMQGIAKRFHGVAALQGVNLTIYPGEVHALMGENGAGKSTLMKILAGAYIADEGEIRINGQPVKITDPGTARKAGINLIYQELNVAPNLTVTENMFMGSELQRGQFLDRKTMELEAQEVLDSLGATFTPQTIVGTLAIAEQQQVEIARALKDKSRILVMDEPTAALSDHETERLFEVIRKLRNDGIAIIYISHRMEEIYALADRISVLRDGQYIGSLTREEISPQRLVQMMVGRSMQDFYEHQRQKSPGAVVLEVRNISDGRKVQPASFQLRAGEILGLSGLVGAGRTEVSRLIFGADRKVSGEVFLNGKKLEIHSPSDAIAAGIGYVPEDRKDQGLFLEMSSRKNIGLNRLKQDAKGGIVNWVSVNKIAADAVENFHIRLANLEIRAVDLSGGNQQKLLLARWLAINPRVLMLDEPTRGVDIGAKSEIYRIISDLSAQGVAILMVSSELPEIVGMSDRVLVMREGQLVGELDDSPGKEITQENIMHYATGASEVTAS
>NZ_AP018274.1|WP_096611075.1|1449365_1450427_-|transcriptional-regulator
MNVKKIPFTTGVAATLLSIVSGTLVSCTNISPNGDTATNTDTKNVTDTTTQSNNGDGLRPVVGDRNVKLQAVGVTLGDLSNPFFVVMAQGAEKEAKKIGGNDVRVTVVSSGYDLNQQFNQIENFVAANTDIIILNAADSKGIRPAVEQARKAGKIVIAVDTGVDADVDATVTTNNVQAGEISCQYIVDRLKGKGNVVIVNGPPVTSVIQRVDGCLKVFAKYPDIKILSKDQNAEGSRDGGLRVMSDILVTFPKIDAVFAINDPSGVGVDLAANQAKRKEFFIVGVDGAPEAIEAIASNDSLYAATATQNPRGMTQKAVQVGNDILHGKKPASPDILIPAKLITKENVSTSTGW

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Crispr_ID: NZ_AP018274_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018274_3

1787453-1787556

Orphan

Consensus_repeat	Method
GAAATAGCCCAGCGTCAAGCTGCTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018274_3

>merge|NZ_AP018274|3|1787453-1787556|CRISPRCasFinder
GAAATAGCCCAGCGTCAAGCTGCTGTGGCGGAGGCGAGAGCTTCTTTTCAACTCATGGAAAGCGGTTCCCGTCCTGAAGAAATAGCCCAGCGTCAAGCTGCTGT

>NZ_AP018274|3|3|1787453-1787556|CRISPRCasFinder
GAAATAGCCCAGCGTCAAGCTGCTGT	GGCGGAGGCGAGAGCTTCTTTTCAACTCATGGAAAGCGGTTCCCGTCCTGAA
GAAATAGCCCAGCGTCAAGCTGCTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018274.1\|WP_096611506.1\|1774675_1775563_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379240
NZ_AP018274.1\|WP_096611520.1\|1785584_1786448_-\|DUF1092-domain-containing-protein	unknown	unknown	gnl\|CDD\|368938
NZ_AP018274.1\|WP_096613432.1\|1791587_1792874_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_AP018274.1\|WP_096611502.1\|1772373_1774122_+\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NZ_AP018274.1\|WP_096611514.1\|1779710_1780727_-\|LD-carboxypeptidase	unknown	unknown	gnl\|CDD\|132882
NZ_AP018274.1\|WP_096611532.1\|1793948_1794842_-\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|239783
NZ_AP018274.1\|WP_096611534.1\|1795016_1796363_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP018274.1\|WP_096611516.1\|1780762_1783471_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|238504
NZ_AP018274.1\|WP_096611536.1\|1796440_1797826_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_AP018274.1\|WP_096611524.1\|1788334_1789552_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NZ_AP018274.1\|WP_096611528.1\|1790676_1791309_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|379137
NZ_AP018274.1\|WP_096611510.1\|1776695_1777586_+\|UTP--glucose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|224131
NZ_AP018274.1\|WP_096611530.1\|1793143_1793653_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096611540.1\|1798567_1800142_-\|NB-ARC-domain-containing-protein	unknown	unknown	gnl\|CDD\|368582
NZ_AP018274.1\|WP_096611526.1\|1789756_1790515_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_AP018274.1\|WP_096611512.1\|1777667_1779575_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|310523
NZ_AP018274.1\|WP_096611518.1\|1784021_1785332_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NZ_AP018274.1\|WP_096611538.1\|1797971_1798520_-\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
NZ_AP018274.1\|WP_096611504.1\|1774187_1774427_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096611508.1\|1775635_1776709_+\|GHMP-kinase	unknown	unknown	gnl\|CDD\|223231

Protein	Function_ID	Function_description	E-value
NZ_AP018274.1\|WP_096611506.1\|1774675_1775563_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379240	pfam13527, Acetyltransf_9, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.4506e-14
NZ_AP018274.1\|WP_096611520.1\|1785584_1786448_-\|DUF1092-domain-containing-protein	gnl\|CDD\|368938	pfam06485, DUF1092, Protein of unknown function (DUF1092). This family consists of several hypothetical proteins of unknown function all from photosynthetic organisms including plants and cyanobacteria.	6.75984e-156
NZ_AP018274.1\|WP_096613432.1\|1791587_1792874_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_AP018274.1\|WP_096611502.1\|1772373_1774122_+\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_AP018274.1\|WP_096611514.1\|1779710_1780727_-\|LD-carboxypeptidase	gnl\|CDD\|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	1.05871e-112
NZ_AP018274.1\|WP_096611524.1\|1788334_1789552_+\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	5.05068e-71
NZ_AP018274.1\|WP_096611534.1\|1795016_1796363_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.4629e-55
NZ_AP018274.1\|WP_096611516.1\|1780762_1783471_-\|CBS-domain-containing-protein	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	2.8299e-148
NZ_AP018274.1\|WP_096611536.1\|1796440_1797826_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.97678e-52
NZ_AP018274.1\|WP_096611526.1\|1789756_1790515_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.54613e-116
NZ_AP018274.1\|WP_096611528.1\|1790676_1791309_-\|radical-SAM-protein	gnl\|CDD\|379137	pfam13353, Fer4_12, 4Fe-4S single cluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2.72912e-51
NZ_AP018274.1\|WP_096611510.1\|1776695_1777586_+\|UTP--glucose-1-phosphate-uridylyltransferase	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	2.55742e-84
NZ_AP018274.1\|WP_096611540.1\|1798567_1800142_-\|NB-ARC-domain-containing-protein	gnl\|CDD\|368582	pfam05729, NACHT, NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.	0.000197672
NZ_AP018274.1\|WP_096611512.1\|1777667_1779575_-\|alpha/beta-hydrolase	gnl\|CDD\|310523	pfam05990, DUF900, Alpha/beta hydrolase of unknown function (DUF900). This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.	0.00048491
NZ_AP018274.1\|WP_096611518.1\|1784021_1785332_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	6.19263e-101
NZ_AP018274.1\|WP_096611538.1\|1797971_1798520_-\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	1.31709e-81
NZ_AP018274.1\|WP_096611532.1\|1793948_1794842_-\|acetylglutamate-kinase	gnl\|CDD\|239783	cd04250, AAK_NAGK-C, AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the non-acetylated, cyclic route of ornithine biosynthesis. In this pathway, glutamate is first N-acetylated and then phosphorylated by NAGK to give phosphoryl NAG, which is converted to NAG-ornithine. There are two variants of this pathway. In one, typified by the pathway in Thermotoga maritima and Pseudomonas aeruginosa, the acetyl group is recycled by reversible transacetylation from acetylornithine to glutamate. The phosphorylation of NAG by NAGK is feedback inhibited by arginine. In photosynthetic organisms, NAGK is the target of the nitrogen-signaling protein PII. Hexameric formation of NAGK domains appears to be essential to both arginine inhibition and NAGK-PII complex formation. NAGK-C are members of the Amino Acid Kinase Superfamily (AAK).	7.87089e-169
NZ_AP018274.1\|WP_096611508.1\|1775635_1776709_+\|GHMP-kinase	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	2.27002e-20

>NZ_AP018274.1|WP_096611520.1|1785584_1786448_-|DUF1092-domain-containing-protein
MGSIWELDFYSRPILDENQKKVWEVVICESPSDVSTNPDSLFRFTKYCPSTEVNSVWLRTAIEEAIAKVGESPSRVRFFRRQMNNMITKACEDAGIAAQPSRRILVLHNWLGERMEQVYPKEPGYQGGTNPSVRLDAPIPQRLPDALESEKWGFVTLSASDFTDMPEWDISFGEGFPLEMMGITGDMPIPGVLLFSSRALPLAAWISGLELASLRFDESQGGRLVLETGATESWILANIRNPSMKNEAMGFNEAKQKVNGVHFIGIQSSPESESFAGFWLLQDVILP
>NZ_AP018274.1|WP_096611518.1|1784021_1785332_-|TldD/PmbA-family-protein
MGFYQSPLSLLAEQLLELAIKFGAEAAEVYQSRSHSQPVFFEANRLKQIETSQAEGTVLRLWRNGCPGLSVAYGSVEPQAMVERALALSQLNPPEAIELSSSQTSVYPDVGKHVPLEQLVAWGKGAIAQIRNVYPEAMCNGDWECDVETTRLINTKGLDCHYTDTTLSCYLAAEWVRGDDFLSVADGQTQRNYLQPEKLAQQIIQRLHWAQENVIPPSGRVPVLFTSKAADMLWGTVQAALNGKRILEKASPWAERINTPVISSSLTLYQDPVQGPFSCPFDDEGTPTRQLVFIRDGILENFYCDRATGRSLGLCTTGNGFRPGLSSYPTPGLFNFLIQPGKTPLKSLISQLDDGLIVDQMLGGGSGISGDFSINIDLGYRVKNGEVQGRVKDTMLAGNVYSVLKQLVALGDDADWNGSCYTPSLIVEGLSITSKH
>NZ_AP018274.1|WP_096611516.1|1780762_1783471_-|CBS-domain-containing-protein
MPSPVLAYRFRNLWQPRRGLAIAEASVIGLVAALSAVLLKFGSGALGTWRVHSSHLFPAWIVLPLVGMVFGFLAGLLVERLAPEASGSGIPQVKATLANVPMNLSWRVACIKLLSAIIAIGSGLTLGRQGPTVQVGAGLAAGMSRWVPTSPDHRRQMIAAGAGAGLAAAFNAPIAGVLFIVEELLQDLSGLTLGTAIIASFIGGVVSRLLGGGSLLLNLQQNQISSSFAITEIPFYLLLGLCAGFLAALFNRGLIYSIKLYRRLHVSLAIRVALAGLVSGIIVSLLSNLSGDNTNLFRDNTGLREFVIATSANTSLAAIAFIVQFLLTLIAFGSGAPGGLFAPSLILGSCLGHIIGAFQENLLHAGSPTTYALAGMGAFFSGVSKVPITAIVIVFEMTTDFNLVLPLMIGSVTSYLVADKLVPGSLYDKLLKLKGINIEYKTSTEGILTKLTAREVMQSRVESLDAEMSVEEAMQAFSRSHHRGFPVVEDSRLIGIVTQTDLLKVGDNPSQEFDKSIIIKQTILRQIMTPEPVTVTPYHNLSNVLYLLDRYKISRLPVVEGKRLIGIITRADIIRTEADHLNCENPEKPPTEPSYVVYQTRSPSTGRGRLLLPIANPDTATTLIKMAVAIARERHYEIECVQIILVPRYSSPAETQVRTTKSRRLLRQTEVLGKKWQIPIHTQIRVAHDVAQAILETISDRHIDILLMGWKGSTDTPGRIFGNVVDTVVRQATCEVMLVKLGTQHIRQEGEISTNQHPALSTEDSEIQFNNWLIPMAGGPNAWLAIKLLPALVTLGNEPKIRLTRVFHPSEVKPDMKVLEDATRQIIRRRQLYTTVIAEAVKAESVSEGVINLVSKGHYDVVVLGASREGMLQQAIKGNIPEAIASGVESTVILVRGAINAE
>NZ_AP018274.1|WP_096611514.1|1779710_1780727_-|LD-carboxypeptidase
MNRRQFITTAGITTLATQFSLSTVQAEIKPQTIIKPPRLQIGDTVGLVAPAGIIEAKDIEDATKTFAELGLKVKLGKYILERYGYLAGTDIQRAHDINRMFADKSVKAIIAMRGGWGCNRILSLLNYIDIRKHPKIILGYSDITSLLLAINARSRIVTFHGAVATSTWNQFTVSYLKPILFDAGIVTMQNLNNIEAGKVEVINPGKAKGKLVGGNLSVISSMLGSPYLPGWNRRIFFAEDIGEDVYRIDRMLAQLKNAGILNQFSGFIFGQCTNCKPGDEPTFQLKQVLQDYIKPLNIPAFYGSMIGHIQDKFTLPLGVDVEIDAVSGTITMLESAVS
>NZ_AP018274.1|WP_096611512.1|1777667_1779575_-|alpha/beta-hydrolase
MQDYPFDIQKIKLEQPALVTSNIVSYLVKSNAPISVETTYKESNNTQAVDDQNKPQETDEIIKEIANFLLLHKHQAEIVIHIHGYNTGEKDFEDWTRNIYHYILNDKFISQKTILFIGYRWPSESIALKSDEDSESFLNNVGNAIQSLPIFFRTILDSSLRGIIASFTLLLIFLIPFTGTALLLNNPDFLVSLLVFVTAFFTFLFGFVFSAILLRSTVYFRDSYRAVNYGVPDLVELIRQIDNAIVEESDKSEGVTRAQKKENLSQSLATSNSRIKLSFIGHSMGAFVTTNVIRILSDVFDEKSIQTQHSPENQPSLKLGTAFSLGRLVLASPDIPIETIMPERSNVLRSSIRRFEESYLFSNQGDFILRVASTAANYLSFPANTYDRGFRLGNVVVRDYDESYDSYNLNSKLLKQKTDVPKITFGIANQNSRDGSINQNPNSAMKCICIVSDNRYKPLDELYSKNTPVTQKLAVAGLFTYFDCTNYRDVTNNNDQVKPILTRALDKEVLSFWDNLFLIFDNFFSGRNVHGGYFDGKFSQKILYRLAFLGFKDMLLSLEDEPDCQELVNKLETEISPKLIQESLQSQTVEPDAEKLTKLLSVLSQKCNNSGIKAFLAPERYQVDILGKERDRKDY
>NZ_AP018274.1|WP_096611510.1|1776695_1777586_+|UTP--glucose-1-phosphate-uridylyltransferase
MPVSKIKKAVITAAGFGTRLFPTTKVVKKELFPVIDKDGRAKPVILLIIEEAISAGIEEIAIVVQPDDKAIFKKLFKRPPSAELFEKLSPENQKFSKYLVDIGDRITVITQAQQEGYGHAVYCAKKWVDNEPFLLMLGDHIYSSKIQKSCARQILEIYQQVNHSVIGLNIVNSEMLHQVGCVTGNWQKQNSILTINQVAEKPTLDYARDNLHVESLGDDEFLSIFGLYALTPTIFDCLEVDINQNVRLKGEFQLTTCLDVLRQREKMTGYLVAGTCFDIGIPDAYLQTLNDFRHRE
>NZ_AP018274.1|WP_096611508.1|1775635_1776709_+|GHMP-kinase
MKIFVPGRLCLFGEHSDWAGCYRRQNPDLGVGYTLLSGTNQGIYASVKQHPQQLILRTTLDDGSEKICALPMEKQALLVEAKKSSFFSYAAGVAYQFLTYFQVGGLEIDNYLTDLPIQKGLSSSAAICVLVARAFNQVYDLKLTLRGEMEFAYLGEITTPSQCGRMDQGCAYGNRPIAMIFDGDRTDIIELHVPENLYFVIVDLGAGKNTQKILSQLNQCYPFPKDEIQANVQKYLGKISYQFTKAAINALQAGDAKEIGQLMRQVQAEFDRYLIPACAVELTAPVLHKLLNYEPIQDYIWGGKGVGSQGDGTAQFIVKNQESQQQVIEIIERDFPQMQCLKLIIYPSNKTSKNTSE
>NZ_AP018274.1|WP_096611506.1|1774675_1775563_-|GNAT-family-N-acetyltransferase
MQTYKFKRSFALDSTLSPRLFNLLDSAFPGLGINELAKQARKLGGVWEHVSTPFARIDDNGTLIAHIGVLEIPMRIMGADVIVGGIHAVCTHPEYRRRGYYREVMKEVLDYCDKRYDTLLLTTDQPGLYQPFGFRVIPEHSFKAKYNSLGSVNGMRSLDISDSDDVKLIHRLLETRTTVSNIVGVFSHKALFLVNECTKPLYYFPNLDTLACLEIHNQQLKLFDLVTPELNFTLQALLEQIPQAIAEVLIYFSPDCLQFAMQAVAEIFEGDSLLMVRGTFAAEHQQFTLPRSARC
>NZ_AP018274.1|WP_096611504.1|1774187_1774427_+|hypothetical-protein
MEYLSKLSVKKNTPAWINANFKIELKTIPLSIAWYKHCYIFLHLLTKKATEILLLPALPRITLYQLTCLLQHLRFALPL
>NZ_AP018274.1|WP_096611502.1|1772373_1774122_+|NAD+-synthase
MKIAIAQLNPIIGDLSGNAQKILAAAQKAATADTRLLLTPELSLCGYPPRDLLLNPSFVAAMGTTLQQLASDLPSNLAVLVGTVEEYLEAPSNGGKSLYNSMALLENGKVKQIFHKRLLPTYDVFDEHRYFEPGLEANYFTLDDIDIGVTICEDLWNDEDFWGKRSYAINPIADLAIIGVDLIINLSASPYSVGKPNFRERMLKHSVIRFQQPMIYTNQVGGNDDLVFDGNSFALNRKGELVCRARGFDVDLAFLEFDSEKRDLQPSSMIPTPANEDAEIWQALVLGVRDYAQKCRFSKAVLGLSGGIDSALVATIATAALGKENVLGILMPSPYSSDHSISDAIALSHNLGIKTQTIPIGELMKSFDTSLAGMFAGTEFGLAEENIQSRIRGNLLMAVANKFGYLLLSTGNKSEMAVGYCTLYGDMNGGLAVIADVPKTRVYSLCNWLNNRGTQGDSELGDAEKIINPIPQNIITKAPSAELKPGQVDQDSLPPYDILDDILQRLIHNHQSAAQIVAAGHESTVVARVIQLVNRAEFKRRQAPPGLKITDRAFGTGWRMPIASNWLAVENQQNNTKKHYVQ
>NZ_AP018274.1|WP_096611524.1|1788334_1789552_+|ABC-transporter-permease
MNIIESMKMAGTTLLSNRLRSALTMLGIVIGNASVIAMIGIGEAGQKYVSKQLESLGPNVLFVLPGNEETQRISFEVPRNLVLADAEAIASQVPTVAGVAPELNRRQRVAFKSRNTDVNVIGTTPGFLKVRDFATAKGRFFSDIDMKRNNQVVVLGSKFANKFFGTNNAIGQQIRIKDSKFEVIGVLTEKGSSVGADYDSAVLIPLTTSANRLVGKNSPYGIALDYISASARDGKSVDAAVFQITNLLRLRHKITNEDDFTLRTQKDALSTVGQITGALTIMLAAIAAISLFVGGIGIMNIMLVSVTERTHEIGLRKAIGATQQDILWQFTIEAVIVSAAGGLVGAAIGVSGIVLVGALTPLEAAISPIAIASAVGISGGIGLFFGVFPARRAAKLDPIVALRSI
>NZ_AP018274.1|WP_096611526.1|1789756_1790515_+|ABC-transporter-ATP-binding-protein
MIASSPVRDSHSPIPQKTIIRLENIFKIYGVGETEVRALSEVNLIIEEGEYCSIMGPSGSGKSTAMNIIGCLDRPSSGHYYLDSLDVAQMEDNELAHIRNKKIGFVFQQFHLLQQLTALENVMLPMVYAGIPNSERRERATEALIKVGLENRLNNKPNQLSGGQQQRVAIARSIVNRPVLILADEPTGALDSRTTQEVLDIFTELNASGITVIMVTHEPEVARQTRRIVWFRDGQVVHSNLTPADLNQVATS
>NZ_AP018274.1|WP_096611528.1|1790676_1791309_-|radical-SAM-protein
MTQQKFNPYLSLVEIPPGYLNIMGYVDASEVNGPGSRAVVWVQGCMRECPGCFNEESWSFEINQLISIDNLAENILADSRNQGVTFSGGEPFWQAPALAQLARQVKAAGLTVMSFSGFTLEQLQSDYAPAGAKDLLAELDILIDGAYVESLAINTPDSPVSSSNQRVHIFNPALQDQINWASDQIEVHIFKDGSRLITGYRGGLELTVGE
>NZ_AP018274.1|WP_096613432.1|1791587_1792874_+|phosphopyruvate-hydratase
MIDTAIANIIAREILDSRGKPTVEAEVHLYNGAIGLAQVPSGASTGTFEAHELRDGEKNRYGGKGVLKAVQNVRDAIAPKLINMDVLNQELLDKTMISLDGSANKANLGANAILAVSLAGAKAGAESLGIPLYRYLGGPLANLLPVPLMNVINGGAHAANNIDFQEFMIVPVGASSFREALRWGAEVFATLAKVLDDKGLLTGVGDEGGFAPNLESNQVALELLVAAIEKAGYKPGQEVALALDVAASEFYKEGQYVYDGKPHAPAEFIDYLAQLTSQYPIVSIEDGLHEEDWQNWQALTAKIGSTVQLVGDDLFVTNATRLAKGIEQKAGNSILIKLNQIGSLTETLETIDLATRNGFRSIISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERVAKYNRLLRIEDELGAQAIYAGKVGMGPKGI
>NZ_AP018274.1|WP_096611530.1|1793143_1793653_+|hypothetical-protein
MLSSLFSSKLSSRTSYIILLALGASATLTMSPPASAQSSTIIYQRTTTYDNYRQPRIIYKRHQTHRNYRQPQVTNFIYRSPVYTPFPVNPYKRQVIQNHNNFYPRSYYQQRVIVQPRARKYINNSTGVNTIFLTPNIRNSNIINPRNLNPYRHYYGNPVQRNSGIFFQY
>NZ_AP018274.1|WP_096611532.1|1793948_1794842_-|acetylglutamate-kinase
MVNDTEYIKQAEATRVRVLSEALPYIQQFAGRTVVVKYGGAAMKDSQLKDTVIRDIVFLSCVGLRPIVVHGGGPEINSWLDKLGIEAQFKNGLRVTDAPTMDVVEMVLVGRVNKEIVSLISQAGGKAVGLCGKDGNLITARPQGQEGIGFVGDVSGIDVNILNTLAENGYIPVVSSVAADETGQAYNINADTVAGEIAAALGAEKLILLTDTRGILKDYKNPGTLIPKLDIQEARDLIATGVVAGGMIPKVNCCVRSLAQGVKAAHILDGRIPHSLLLEIFTDVGIGTMLVGSNFMP
>NZ_AP018274.1|WP_096611534.1|1795016_1796363_+|serine/threonine-protein-kinase
MLQPQEILIERYQLQRVLGESVSRQTWLARDLLNREQVVVKLLIASDKLQWDNLRLFEREAKVLRQLDHPYIPEYRDDFVVKKNQEIISFALVQEYIPAKSLKEVLLEGKIFSETEARKIAIALLKILIYLHKLSPPVLHRDIKPSNLLISESEGKKNKIYLVDFGAVQDRAASEGATFTVVGTYGYAPLEQFGGRATPASDLYALGATLVNLVTGIAPADLPQLDSKMQFSHLAQLNPGFVRWLQKMTEPNLEYRFQNASAALEALEINQSAVSTTGVSQDIPHTPILVSKSANKLVVHIPGNKNKFGLVIGGVGLTLWVLFWLPILTMNFPFNPRVIWILIWLILGFVFTAWWTLPSHVESYICLDNRAFEIKWKLFGFTVKTQRGNVSDIDKVYSSKTGNSDMKKLYEIILSLGVNEYYFGSVKNNLSLEESRYIASEIRDWLGL
>NZ_AP018274.1|WP_096611536.1|1796440_1797826_+|serine/threonine-protein-kinase
MLESGQILENNQNHYRLEKKLGQDTSRQTWLATLLDSRSQQTLTSGISHTEQVVLKLLTLSPQIQWDEQKLFEREAQVLQNLNHSRIPKYRDSFIIENLPGSKFSWFVLVQNYIPGISLQEALNQGQRFSESQVEKIAIEILSILVYLHELNPPLLHRDIKPSNLILGADERVYLVDFGAVQDKAVAEGVTFTVVGTYGYVPMEQFAGRAEPASDLYALGATLIHLLTGTSPADLPYENYRIKFTHLVSIDLGLVNWISKLTEPNIRDRIPTAREAITVLENKYNLSPPITNRKPTGSKIQLQKSANSLEIKLPQRGRKSLRTFYLIGLFTPFIWQIFQFTNWSINANGNILFYIIIILLLSSAILKTILLPVFGHTDLYFDREKFEIQWKIFGFCYKRKRGNIIAIEHIYKENPKTALAPMGITIELIKGQKFTTTPLATIERNWLIDEIADWLQFDLNK
>NZ_AP018274.1|WP_096611538.1|1797971_1798520_-|shikimate-kinase
MTDSLKGINVYLIGMMGAGKTTVGRLLARHLHYGFLDTDNVITQAAGKSINEIFATVGEAGFRQFESDILGQVCAYTKLAIATGGGIVIRRENWGYLRHGLVVWLDVPLDLLYSRLAKDTTRPLLQDSDPQGKLKSLLEQRTPLYSQADLHITISECDTPENVAQRIMDAIPSVLKKDNSQN
>NZ_AP018274.1|WP_096611540.1|1798567_1800142_-|NB-ARC-domain-containing-protein
MTASEPHIVEEEFVEAKNNWELEKLYIDLASAKGKALTPVEKKFLRGLLCGFSPAEIASTVYKSKSSSTVRVYLSNGLYKYIEEMLSIQASTNIKVKNWSRVTQLLEKAGYKKTWLKLEAVSNPVTTNYVKKEAAELVNMQTAQQDWGEATDVSVFYGRQNEIAQAQNWIIQERCRLVVLLGMGGIGKTTLSIKLAQKLHSEFDFIIWRSLQLAPPLEVLLNQLIQFLSVNPDMEIADSLEGSISQLIEYLRSARCLIVLDAVDAVLSGDAAESQESVYALAQIKYLPGYEDYGELIRRLGESSHQSCVLLTSRKQPQAIAALSGNSLPVRVLKLTGLGYGDGLEVLKAKGFSNIKQEEYQFLIDWYTGNPLFLKLVGTAIQDLFGGSIYEFIEQGTVVFGEIRAVLDEQFQHLSQLEKQVMYWLALNQDFLSLRKLQRDIVPRVSQRLILEAIELLQRKSLIERQTASFSQTPVLMEYIAECLIEENIRLSGTQASSLLMNQTIFETQLKNYIRELRFNADNI

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Crispr_ID: NZ_AP018274_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018274_4

2418093-2418190

Orphan

Consensus_repeat	Method
ATCCCGTCATTGAGAGGAGGAACGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018274_4

>merge|NZ_AP018274|4|2418093-2418190|CRISPRCasFinder
ATCCCGTCATTGAGAGGAGGAACGACTACGCAATCGCAATGACGATGAGCGTCATCCACAAATAGACAAACCATCCCGTCATTGGGAGGAGGAACGAC

>NZ_AP018274|4|4|2418093-2418190|CRISPRCasFinder
ATCCCGTCATTGAGAGGAGGAACGAC	TACGCAATCGCAATGACGATGAGCGTCATCCACAAATAGACAAACC
ATCCCGTCATTGGGAGGAGGAACGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018274.1\|WP_096612431.1\|2411875_2413108_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612445.1\|2419763_2420018_-\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	unknown	unknown	gnl\|CDD\|274227
NZ_AP018274.1\|WP_096612435.1\|2414482_2414938_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|369489
NZ_AP018274.1\|WP_096612433.1\|2413343_2414321_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_AP018274.1\|WP_096612459.1\|2425594_2426890_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_AP018274.1\|WP_096612453.1\|2421856_2423833_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_AP018274.1\|WP_096612429.1\|2411407_2411770_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612441.1\|2416854_2417271_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612443.1\|2419446_2419752_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226194
NZ_AP018274.1\|WP_096612455.1\|2423875_2424322_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378550
NZ_AP018274.1\|WP_096612423.1\|2407447_2409496_-\|S-layer-protein	unknown	unknown	gnl\|CDD\|335962
NZ_AP018274.1\|WP_096612425.1\|2409612_2410608_-\|homocysteine-S-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376828
NZ_AP018274.1\|WP_096612439.1\|2415889_2416390_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|225943
NZ_AP018274.1\|WP_096612449.1\|2420392_2420596_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374224
NZ_AP018274.1\|WP_096612427.1\|2410842_2411160_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612451.1\|2420820_2421003_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612447.1\|2420171_2420396_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_AP018274.1\|WP_096612437.1\|2415107_2415764_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_AP018274.1\|WP_096613513.1\|2421270_2421504_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612457.1\|2424516_2425017_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP018274.1\|WP_096612445.1\|2419763_2420018_-\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	gnl\|CDD\|274227	TIGR02606, Antitoxin_ParD, putative addiction module antidote protein, CC2985 family. This bacterial protein family has a very similar seed alignment to that of pfam03693 but is a more stringent model with higher cutoff scores. Proteins that score above the trusted cutoff to this model almost invariably are found adjacent to a ParE family protein (pfam05016), where ParE is the killing partner of an addiction module for plasmid stabilization. Members of this family, therefore, are putative addiction module antidote proteins. Some are encoded on plasmids or in prophage regions, but others appear chromosomal. A genome may contain several identical copies, such as the four in Magnetococcus sp. MC-1. This family is named for one member, CC2985 of Caulobacter crescentus CB15. [Cellular processes, Other, Mobile and extrachromosomal element functions, Plasmid functions].	4.31801e-10
NZ_AP018274.1\|WP_096612459.1\|2425594_2426890_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	9.59128e-161
NZ_AP018274.1\|WP_096612443.1\|2419446_2419752_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	3.48204e-17
NZ_AP018274.1\|WP_096612433.1\|2413343_2414321_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.46865e-52
NZ_AP018274.1\|WP_096612453.1\|2421856_2423833_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_AP018274.1\|WP_096612455.1\|2423875_2424322_+\|hypothetical-protein	gnl\|CDD\|378550	pfam11068, YlqD, YlqD protein. The structure of a representative of this family has been solved (Structure 4dci) and found to form a tetrameric structure of prefoldin-like architecture with the beta-barrel core and helical coiled coil tentacles. This suggests that this family may act as molecular chaperones.	2.44563e-39
NZ_AP018274.1\|WP_096612423.1\|2407447_2409496_-\|S-layer-protein	gnl\|CDD\|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	4.28991e-33
NZ_AP018274.1\|WP_096612425.1\|2409612_2410608_-\|homocysteine-S-methyltransferase-family-protein	gnl\|CDD\|376828	pfam02574, S-methyl_trans, Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.	1.14494e-39
NZ_AP018274.1\|WP_096612439.1\|2415889_2416390_-\|peptidoglycan-binding-protein	gnl\|CDD\|225943	COG3409, COG3409, Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane].	3.96977e-21
NZ_AP018274.1\|WP_096612449.1\|2420392_2420596_-\|hypothetical-protein	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	8.3563e-13
NZ_AP018274.1\|WP_096612435.1\|2414482_2414938_+\|histidine-kinase	gnl\|CDD\|369489	pfam07730, HisKA_3, Histidine kinase. This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.	1.56881e-05
NZ_AP018274.1\|WP_096612447.1\|2420171_2420396_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	8.75647e-18
NZ_AP018274.1\|WP_096612437.1\|2415107_2415764_+\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.41131e-77

>NZ_AP018274.1|WP_096612441.1|2416854_2417271_+|hypothetical-protein
MEPITAATIATLAFTKVFEKTIEKFTEAALQKMDELRKKIFDKFRGNVKVETALRAAEKGSKKDLDTVAAYLQVLMHEEPLFAEEIRAIARDIKAGEKQDNSTMTQINQDNARGWQTKVDGGTAYIGENTINQAPPNS
>NZ_AP018274.1|WP_096612439.1|2415889_2416390_-|peptidoglycan-binding-protein
MTTATSILPLKEGSVSEGVSIIQGFLTTLKLYSAKIDGSFGAKTKEAVIKFQGANGLTKDGIVGNNTAIALDNESWAAQQPVLKEGAKGADVEAFQGLYNSYFGTLAVDGIFGAKTKAEVIKFQKSRNLTADGIVGAKTWSSLRSLTTHDIPTEDRISFIFEPQGC
>NZ_AP018274.1|WP_096612437.1|2415107_2415764_+|DNA-binding-response-regulator
MIRLLLVDDQSLVRQGLKAILSLETDLEIVGMAENGEEAIAQVEALQPDVILMDVRMPVMNGANATRIICEKYPQMKILVLSTYDEERDVSDVIRAGAKGYLLKDMPSEELVNAIRCVNSGYAQLAPGLLERIVNQPSSPVNTSPATSPPLTELTTRELDVAKLVATGATNQEIADELYISESTVKTHINSIFHRLNLKNRAQLAIYANSALSHTTSS
>NZ_AP018274.1|WP_096612435.1|2414482_2414938_+|histidine-kinase
MFYRYQAKYMLAVLLLVAFLLTLIWQLVNAVHANHQKHCQLILFEQQINLYTSQIVKMTEIQEKNQNLVNLYNALGQSIAALNIQLQVAQKCWFINPEQAHESLTDASQLSASLMYEVRQIVKEMSVEQVIRENSKCYASQAEIYLLSTKY
>NZ_AP018274.1|WP_096612433.1|2413343_2414321_+|sensor-histidine-kinase
MVEELYTPEELAQMHDSLWQCVLQFANLSAKQERDRIARDLHDSLGHSLTALNFQLQTAMKLCQPNPSQAQEFLTEAHRLVGIATREVRQSVKALRSEAVETQSLETLIESLVSDFERTTGILPEVNIDLPIALSSYLVTPVYRITQEALNNIRKYAKATAVQINICTTPTGIYLIIKDNGCGFDVTQVSGGYGIQGMKERVAVLQGRLQLESKPGEGCCISVGIPMQISRLPEIISHEENTLIQPNLPSDLSQSNLSQSDFSQKDAIAESQLTTLYNFTNLEAVNITNTSTNFDTEDIQQEQEFLISSSRMVKISEWQPLNLNA
>NZ_AP018274.1|WP_096612431.1|2411875_2413108_-|hypothetical-protein
MPSINLLAVFNPSNYWRSGYVTVPWQPIYQEFQIPPVELTLSDLRDLSRTPLCAQVDCIDPKNSERDRLVFSLPQPIPPGSPDNMLASGFIKVDRGKAIPQGLSEASVEVVYGANGQERGVRLSNSRLIVWFSLIPAPEDSDRNWFSGSATSIQLDHQEILDPFLAARGEWLGQDPEKRCMQVAGIQLPGAGEPKLPYYQVHLYNHSYRLISQSSGCVRASITIASEPFDYMGIDPNTGYNRHLVCELYRVISLYAGADFLVEELFVKGKPKTNEGAILDSSEVIYLDFGLRYFAHMNMGHTEDIQQVFPVPDWFAIGSTEPPYPAYGLASNLHIESLIHPYGGNLSGLSWQLLPGKSATCLHLFMRNQANDFDTRIGHLWYEMIHSPLRAEIYDTGLKSKVQKQIFAQL
>NZ_AP018274.1|WP_096612429.1|2411407_2411770_+|hypothetical-protein
MFNNKRFLALSIAGIAGLATILATASQVQAERSFTTNKAEQGYSVAQIYRYPGEGRYPGDDRYPGEGRYPGNPNRVVLARMWERERMRRYHECRYRFNHRPWMCDRILRERNPYEGHRWN
>NZ_AP018274.1|WP_096612427.1|2410842_2411160_-|hypothetical-protein
MSHLQKVINITLLTTVLFAPAAMAQQQSLSIPTDRLEQQVPCKDRHGKPVPCPWQKPSQTDLTTGDTSTEKKPNPCNPKKGQPVDTKACRDYINGNPKPPTQPKS
>NZ_AP018274.1|WP_096612425.1|2409612_2410608_-|homocysteine-S-methyltransferase-family-protein
MARYRDSLPQLSSDLFLTDGGLETTLIFREGITLPDFAAFDLLKHRQGYQALEQYFRTYASMAQKYGVGFILESATWRANPDWGRKLGYDHQSLAEMNRRAIALLDEIRQEYETEKTRMVISGCIGPRGDGYVPTEVMTENEAELYHRQQIQTFRDTDADMVTAITMNYPEEAIGITRAAKLAEMPVAISFTVETDGKLPTGQSLKDAIEQVDTVTDYTPVYYAINCAHPTHFADVLAANEPWVKRIRGIRANASIKSHAELNESLELDDGNPEELGSQYHQLLNNLKHLNILGGCCGTDERHVEAICKAVLPLLWAHLSNTQTINRYLFT
>NZ_AP018274.1|WP_096612423.1|2407447_2409496_-|S-layer-protein
MSDIGLLMAGILTTGQATLSELPEEPAIQPDSVQESDKEEKAVNTEVSSQSSLKNTIAPPELTLSENSSQPAISELTQKQKKLLNKITEKVKRDGEIQELSQSPHLPITASPNHRVSQSPSLPITAPPPYPTSPSPTPEFIDSTSLDSKFLDSISTDSKSPDSTFPDSKFPDSTSTDGMSQVTSVSQLGDIDSSHWAFSAVQSLVERYGCVAGYPDGTFKGNRSMTRYEFAAGLNACLDKINELIATNQENLAKQEDLIELQRLQAEFQPELTILQARLNNLEERTAELEANQFSTTTKLYGQAIFSVQGTNEGDIFLYRGEETPRKAETNVTFTSSSQLTLATSFNGRDLLLTGLAAGNLGSSTQAVSTNMGRLGFESDTGNNDVYLNELSYRFPVSDNFGVVVGTAGVNPINTFRGINPLEGSGDGAISLFGQRNPILAIGSSTSGVGFDWQISDRISLQGIYSAQIASFPGDINVGGLFGGNYTAGAQITVAPTDNVDIGVHYLFNHSPDGNLRTGVGDTQLVSPFAPQTTFDTHAVGATVAWRVNPNLQLGGWGGWTASNPVNLSGTVETTNWALFAAFPNLFRPGNLGGLIVGQPPKITSSTLPDGYNLPNFALPDFETGGGKGGREDTSLHLELFYRAQINDNISLTPGLFVIFNPNHNNDNDTLVVGAMRATFRF
>NZ_AP018274.1|WP_096612443.1|2419446_2419752_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSNICRFTAPASRDIESIIDYVADNCSFDAAESLLKKINQKCQNLANFPNVGRRRDELSPFLRSFPVDNYLIFYRQIEDGIEITRVISGYQDLDALFDKDS
>NZ_AP018274.1|WP_096612445.1|2419763_2420018_-|type-II-toxin-antitoxin-system-ParD-family-antitoxin
MSISLTPELEQFIQNQVASGKYTSTEEVIIAGIKLLEERENIYKGRFEELKREIAIGVEASERGEIIDGEIVFRQLEQKLQQRR
>NZ_AP018274.1|WP_096612447.1|2420171_2420396_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MTRIRRMGADEVERILQSYGFELISQKGSHRKWRNDDRQLQVIVPYHKGRDLPIGTLRNIMIGADIPEFEWKTD
>NZ_AP018274.1|WP_096612449.1|2420392_2420596_-|hypothetical-protein
MKWRVVLEPDPETGEWAVWCPELPGCTSAGDTEEEALENIREAIQLYLETDPIKLAPGAIFREVMVG
>NZ_AP018274.1|WP_096612451.1|2420820_2421003_-|hypothetical-protein
MNLIDGLFLTAANAIVCIVFPKLLYTILAAKRQQREVVLETPKSTQADTEITSEVPSYPY
>NZ_AP018274.1|WP_096613513.1|2421270_2421504_-|hypothetical-protein
MDILFLTLVSAAACIALPRLISMILALGGKPIQKHHVITLQNARQEVTSFPFCTTYSLTRTPACKFSPHFCGQCSHQ
>NZ_AP018274.1|WP_096612453.1|2421856_2423833_+|long-chain-fatty-acid--CoA-ligase
MVRTSADPNFFSTYTEQERIYAKDLIDYADVETLPEIWSLVATRYPDIVAVCDPHAKPEVFFTYTQLHEKIQCFAAGLQVLGVKEGNRVALISDNSPSWLIADQGIMMAGAVNAVRSSLAEREELLFIISNSGSTALVLENLKTLKKLREGLHELPIEFVVLLSDEQPGSDESLKVLNFSQLMEIGQQHHLQPVQRQRQDLATLIYTSGTTGKPKGVMLTHANLMHQVTSLGSIVRPKPGDTVLSILPTWHSYERSCEYFLFGQACTQIYTNLRSIKSDLKKFAPNYIIAVPRLLESIYEGIQKQFRDQPASKQRLVNNLLGISEKYIKARRIAQGLDLENFQASALQRLLASLKATVLSPLHAVGDKLVYSKVREATGGKIKQMVSGGGALPRHIDLFFEIVGVEILVGYGLTETSPVTHVRRVWRNVRGAAGQPVPGTEIKIVDAETRKPLAVGERGLVLLRGPQIMQGYYQNPEATAKAIDSQGWFDSGDLGWVSEKNDLILTGRAKDTIVLTNGENIEPQPIEDACLRSPYIDQIMLVGQDQRCLGALIVPNVEALEKWAESQDLKLCIQEDNVTLAGSQKINLESKIVQDLFRQEMNREVQNRPGYRLDDRINPFRLILEPFSIENGLMTQTLKLRRHVVMERYRDTINNMFA
>NZ_AP018274.1|WP_096612455.1|2423875_2424322_+|hypothetical-protein
MDVSKQLLLKRAVNVKAIVTPLWKEEVQQQLQAQINQIDQQLQQIDIQGQRAVSEIQKQSMQPPGPQTLQQIDNIQAQVNEKKSELLEQKNQSLQNLQQVQLLELDQEVNQFQMEGFFRVEPGDNLISKLQVEVVIRDGVVEEIRGDI
>NZ_AP018274.1|WP_096612457.1|2424516_2425017_-|hypothetical-protein
MSAKLKIFLILVLGIFATAAVGSIFTNRQLITAISANQNVQAQQPPVAIQTTSLAVNPERAKYKTIPLENINSGLQGTDPASLAMNVFDTAQGDRTKRQVEVVYPYPNQALVTITQNKPTRNQNYRSAVRYRVELTSFGRTIFASSPPMWQIVWVGSQEQCGKRYC
>NZ_AP018274.1|WP_096612459.1|2425594_2426890_+|2-oxo-acid-dehydrogenase-subunit-E2
MSIHEVFMPALSSTMTEGKIVSWVKSPGDKVEKGETVVVVESDKADMDVESFYEGYLAHIIVPAGDSAPVGNAIAFIAETEAEIADAVAKASSISTPVVAPLAAASKGSSTTAVVEPVTTSQNGSNHREGRIVASPRAKKLAKELKVNLNAIAGSGPFGRIVAEDVETAAGKVSAPPAVTPITAPTTTPISTPAAPKPLPTPVAAVVPGQTTPFTTLQNAVIRGMVASLAVPEFRVSYTITTDALDKLYKQLKSKGVTMTALLAKAVAVTLQKHPLLNASYSDQGIVYHSGINIAVAVAMDDGGLITPVLQNADQVDIYSLSRNWKSLVERARAKQLQPEEYTTGTFTVSNLGMFGVDTFDAILPPGQGSILAIGASRPQVVATTDGMFGVKQQMQVNITCDHRIIYGAHAAAFLQDLAKLIETNTQSLTM

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Crispr_ID: NZ_AP018274_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018274_5

2516343-2516445

Orphan

Consensus_repeat	Method
TTAGCTCAGTTGGTAGAGCGATCGACATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP018274_5

>merge|NZ_AP018274|5|2516343-2516445|CRISPRCasFinder
TTAGCTCAGTTGGTAGAGCGATCGACATTAATCGATTGGGCGCAAGTTCAACTCTTGCATCGTACACCAAAAAGTTAGCTCATTTGGTAGAGCGATCGACATT

>NZ_AP018274|5|5|2516343-2516445|CRISPRCasFinder
TTAGCTCAGTTGGTAGAGCGATCGACATT	AATCGATTGGGCGCAAGTTCAACTCTTGCATCGTACACCAAAAAG
TTAGCTCATTTGGTAGAGCGATCGACATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018274.1\|WP_096612579.1\|2507999_2509361_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|206646
NZ_AP018274.1\|WP_096612589.1\|2512047_2512707_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|235662
NZ_AP018274.1\|WP_096612605.1\|2524519_2525602_+\|photosystem-II-q(b)-protein	unknown	unknown	gnl\|CDD\|130221
NZ_AP018274.1\|WP_096612611.1\|2529886_2530111_-\|KTSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|379296
NZ_AP018274.1\|WP_096612599.1\|2518599_2520333_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223510
NZ_AP018274.1\|WP_096610164.1\|2513427_2514570_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_AP018274.1\|WP_096612587.1\|2511190_2512021_+\|DUF4351-domain-containing-protein	unknown	unknown	gnl\|CDD\|227751
NZ_AP018274.1\|WP_096612591.1\|2512818_2513442_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018274.1\|WP_096612593.1\|2514662_2515331_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018274.1\|WP_096612609.1\|2528390_2529797_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_AP018274.1\|WP_096612603.1\|2523779_2524166_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238779
NZ_AP018274.1\|WP_096612583.1\|2510117_2510354_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612581.1\|2509813_2510044_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612613.1\|2530266_2535399_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_AP018274.1\|WP_096613531.1\|2526150_2527371_-\|geranylgeranyl-reductase	unknown	unknown	gnl\|CDD\|177713
NZ_AP018274.1\|WP_096612585.1\|2510470_2511109_-\|thiamine-biosynthesis-protein-ThiF	unknown	unknown	gnl\|CDD\|366360
NZ_AP018274.1\|WP_096612607.1\|2527540_2528023_-\|DUF4440-domain-containing-protein	unknown	unknown	gnl\|CDD\|227212
NZ_AP018274.1\|WP_096612597.1\|2517037_2518564_+\|membrane-protease-subunit,-stomatin/prohibitin	unknown	unknown	gnl\|CDD\|259816
NZ_AP018274.1\|WP_096612595.1\|2515436_2516021_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612601.1\|2520925_2521867_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154

Protein	Function_ID	Function_description	E-value
NZ_AP018274.1\|WP_096612579.1\|2507999_2509361_+\|hypothetical-protein	gnl\|CDD\|206646	cd00880, Era_like, E. coli Ras-like protein (Era)-like GTPase. The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.	4.39198e-13
NZ_AP018274.1\|WP_096610164.1\|2513427_2514570_-\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	8.20706e-07
NZ_AP018274.1\|WP_096612605.1\|2524519_2525602_+\|photosystem-II-q(b)-protein	gnl\|CDD\|130221	TIGR01151, Photosystem_QB_protein, photosystem II, DI subunit (also called Q(B)). This model describes the Photosystem II, DI subunit (also called Q(B)) in bacterial and its equivalents in chloroplast of algae and higher plants. Photosystem II is many ways functionally equivalent to bacterial reaction center. At the core of Photosystem II are several light harvesting cofactors including plastoquinones, pheophytins, phyloquinones etc. These cofactors are intimately associated with the polypeptides, which principally including subunits DI, DII, Cyt.b, Cyt.f and iron-sulphur protein. Together they participate in the electron transfer reactions that lead to the net production of the reducting equivalents in the form of NADPH, which are used for reduction of CO2 to carbohydrates(C6H1206). Phosystem II operates during oxygenic photosynthesis and principal electron donor is H2O. Although no structural data is presently available, a huge body of literature exits that describes function using a variety of biochemical and biophysical techniques. [Energy metabolism, Electron transport, Energy metabolism, Photosynthesis].	0
NZ_AP018274.1\|WP_096612611.1\|2529886_2530111_-\|KTSC-domain-containing-protein	gnl\|CDD\|379296	pfam13619, KTSC, KTSC domain. This short domain is named after Lysine tRNA synthetase C-terminal domain. It is found at the C-terminus of some Lysyl tRNA synthetases as well as a single domain in bacterial proteins. The domain is about 60 amino acids in length and contains a reasonably conserved YXY motif in the centre of the sequence. The function of this domain is unknown but it could be an RNA binding domain.	3.19732e-19
NZ_AP018274.1\|WP_096612599.1\|2518599_2520333_-\|ATP-binding-protein	gnl\|CDD\|223510	COG0433, COG0433, HerA helicase [Replication, recombination, and repair].	4.35896e-52
NZ_AP018274.1\|WP_096612587.1\|2511190_2512021_+\|DUF4351-domain-containing-protein	gnl\|CDD\|227751	COG5464, COG5464, Uncharacterized conserved protein [Function unknown].	2.49038e-34
NZ_AP018274.1\|WP_096612601.1\|2520925_2521867_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.67872e-16
NZ_AP018274.1\|WP_096612593.1\|2514662_2515331_+\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	5.48408e-33
NZ_AP018274.1\|WP_096612609.1\|2528390_2529797_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_AP018274.1\|WP_096612603.1\|2523779_2524166_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238779	cd01521, RHOD_PspE2, Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins.	7.19766e-59
NZ_AP018274.1\|WP_096612597.1\|2517037_2518564_+\|membrane-protease-subunit,-stomatin/prohibitin	gnl\|CDD\|259816	cd13438, SPFH_eoslipins_u2, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial SLPs remain uncharacterized.	1.2682e-102
NZ_AP018274.1\|WP_096612613.1\|2530266_2535399_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	3.10542e-90
NZ_AP018274.1\|WP_096612585.1\|2510470_2511109_-\|thiamine-biosynthesis-protein-ThiF	gnl\|CDD\|366360	pfam00899, ThiF, ThiF family. This domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1.	1.33211e-28
NZ_AP018274.1\|WP_096612607.1\|2527540_2528023_-\|DUF4440-domain-containing-protein	gnl\|CDD\|227212	COG4875, COG4875, Uncharacterized protein conserved in bacteria with a cystatin-like fold [Function unknown].	9.84374e-51
NZ_AP018274.1\|WP_096612589.1\|2512047_2512707_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|235662	PRK05986, PRK05986, cob(I)yrinic acid a,c-diamide adenosyltransferase.	2.95565e-104
NZ_AP018274.1\|WP_096612591.1\|2512818_2513442_+\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.96313e-21
NZ_AP018274.1\|WP_096613531.1\|2526150_2527371_-\|geranylgeranyl-reductase	gnl\|CDD\|177713	PLN00093, PLN00093, geranylgeranyl diphosphate reductase; Provisional.	0

>NZ_AP018274.1|WP_096612595.1|2515436_2516021_-|hypothetical-protein
MQYPLQLTFKFWAFSPQISVVDAQGSLQFYVKQKLFKLKEAITVFADAERTRSLYYIKADRIIDFSARYDFTDENGAIIGAVKRQGLKSLWRARYDVFNGESVSFTIQEKNPWVKVADALFQEIPLVGMLSGFVFNPTYLVLRADGAVVMRLEKIPSFLSRQFTIKALDSLNEKEEKQVLLSLMMMLLLEKNRG
>NZ_AP018274.1|WP_096612593.1|2514662_2515331_+|hypothetical-protein
MSPRQLTFTPDSKNLISASSDKTIKFWNLNNGRLVRTLKEHNDWVMTLAISPDSTTLASAGGAYEIDSDTAIRLWDIQTGKLIKTFPRTPEAIGVLAFSPDGKTLVSSTGKLQTNTTINFWDINSGKLVSNISENTVSLIFSKHGEHLLTVSSSYAVDLWNISNGKKIKNLVAGIKLDNDQNIGRIYVSAATLHPDGKTLAIGEGGVLSGYRIGIRQISFDK
>NZ_AP018274.1|WP_096610164.1|2513427_2514570_-|IS4-family-transposase
MLPELYQKHLKSQLSLADYIFLKILIALLQSIKKVSLETLATVLPIPITFESRRKRIQRFLSLPNLSIEKIWFPIVTTWLETEFTSEKIVHVVIDRTNWACVNLFMVSVVWDKRAFPVYFELLPKLGSSNINEQTAIISKVLPVFKNHKICVLGDREFCSIKLANWLRERSIYFCLRIKKNHLVEMQTDIWLELNELGLSPGVSFFLKGVKVTKSQGFTSFNLACKWKRKILGVAPEEGWFILTNLDSLESAIAYYKKRFDIEEMFRDFKSGGYNLEGTNVSGERLIVLITLIAIAYTSATIQGQEIKRKGIQKYVGRVKEYGRTQRRHSSFYIGLYGNNWVNFMEPCIELVTELMKFNINKRKYYQRGLRAMRLILSAS
>NZ_AP018274.1|WP_096612591.1|2512818_2513442_+|hypothetical-protein
MKNFILSNHLLGIQKNFLPIALFLSVIGVNIVCINLVKANISEFNEKNNLTKITSQSKINHNHLLASQNKNTSINQPCKLVNYEAAENFIFTLKGQHNYDIDSLAFTPDGKTLVSGSIYNKINIWDFEKQQLKKVINAGKDGVNTIAISADGSLLAAGGGFSQPDTDTTIKVWNLKTGRMIFKFTGHSQGINALTFLTGRQKSLGGR
>NZ_AP018274.1|WP_096612589.1|2512047_2512707_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MEIDKSWETTSDAAVLETAGLTDAQYQKKMQRRKQVQEQRIAEAIPEKGLIIVNTGNGKGKTTAALGMVLRSLGHGYKVAIIQYIKGAWEPAEKKVFSLWEDQLEFYAMGEGFTWETQNRDRDAKIAQAAWQKSLEYIRNPDFRLVLLDEINIALKLGYLAVEDILAGLAEKPAPSHVILTGRGAPPELIKRADLVTEMTLVKHPFREQGVKAQAGIEF
>NZ_AP018274.1|WP_096612587.1|2511190_2512021_+|DUF4351-domain-containing-protein
MSFDNLCKLLSEKYPDRFAKWVLGSEQASVEVLKTELSIEPIRADYVTFLQLKGRILHLEFQTKWESNPPLPLRMLDYWVRLHRLYRLPVTQVVVLLLPPAEGTIIETVFTLESTRHEYRVIRLWEQDPTPLLNDSALLPLASLAASNNSEALLQNVAQRVAQLEPEQRREVSSYVQILAGLKFKKGFIQKMFREGMMRESVIYQDILQEGRQEGREEEARSLILRQLNHKIGILPEQLKLRFGWLSVDELEALGEALLDFTQMADLESWFENYQE
>NZ_AP018274.1|WP_096612585.1|2510470_2511109_-|thiamine-biosynthesis-protein-ThiF
MSIYFHEQLHRTPALMNKLRDFPVTICGAGALGANIAESLARSGCGKLRIIDRDRIEERNLSTQPYYRSDVGAYKTKILANIIYRALGITVEGITKELTAANTTQLLSGSKLVIDAFDNSIARQAVTDNCSNVQIPCLHVGLASDYAEIIWNPAYRVPSSANDDVCDYPLARNLVMLAVAIASETAINFISTQQQQSFTVTLADFAVKPFNI
>NZ_AP018274.1|WP_096612583.1|2510117_2510354_-|hypothetical-protein
MEPNQKELRTVANQEFIEALNQLGDILQESPPDEEEAALVEIQPEESSESESDQKFDLAAWEDAVADIEQYLENRTST
>NZ_AP018274.1|WP_096612581.1|2509813_2510044_+|hypothetical-protein
MSTKNLEFFNAKEITVTLPKHYVQRLYNLLRDNSQGKGTNKDKDSLNLQERVERMLQNPEDRDILAYLDWILKHND
>NZ_AP018274.1|WP_096612579.1|2507999_2509361_+|hypothetical-protein
MSNKLKTINIAIAGHTNTGKTSLIRTLMKSPIGEVGDCANVTKKGEAYYFESLQATFIDTPGFQYAPIVMMCLDAKKENPEFKISEKWESKINYDRDAIAALEDSDVVIYVASLSVVPDDSYQEEISIIRHKSTKIVGVINQYKKQLEATNKDIVDGRVHQWESFFREQSIEQIVVFDAHWDNPIKVNQLYKSIFEILNDEQKSCFTEGLRRFKDRQQKIRKEACKMLSTLIIDCRNEAIVSIPKKDSENKDKIEEAQRQLVEKINHHLYLFVEPVSLLYKIAAENPTTSEEEIIFKIRSEPNWRERAGIGANAAAVLAALSGLLGGIIGFAIVPGTGFINGFAVGSQLGTVIGGAIGSLAIFSDENDTVAIKLDNEQLKIILIKGLAIIWGLSSNGYGRAKELTLQESRYIEEDVSSFRTQQNNINLMSANESKIVEFCEKLLNSLESESKY
>NZ_AP018274.1|WP_096612597.1|2517037_2518564_+|membrane-protease-subunit,-stomatin/prohibitin
MWKSFYIKPNEIGILYNRSDFKKILQPGTYTYFGRNWQVKTYDLNEPEANIENLELLLRNHGSELQEHVVIVRTTFRQAALVRLGQNWVSVKPNQLRAFWRGFIEVETHIFDLEENLELPGNFVQQIRGISLFGLNKFQISEAEIGLLYVQNNFVRPLQPGEYAFWNLDKTIAVNKISRIIPNPDFPLPEVLIERHPDFVAAYCEIVQLQNNQVAIVRYQGKVIAILAPCDRKLFWQGVEVEVIDIGVDAKLPQHLVAELISGVPATYTLSHNSLHVCEVPPQHIGLLYINQEFQTQLQPGLHAWWIFGRSLQTPVFDLRQQNLEISGQDILSKDKVPLRLNLTAGYRIVDPLQAKNTLVDISGYLYKELQFALRGAVGEKTLDALLEDKGAVDISISEYIRQKTSAYGIEVDSVGVKDIILPGEIKTILSKVVEAEKAAQANVVRRREETAATRSMLNTARVMEDNPVALRLKELEVLERIAEKIEKIQVNGSLDSILTDLIRMNRE
>NZ_AP018274.1|WP_096612599.1|2518599_2520333_-|ATP-binding-protein
MQLGQPLGSVTQGSLTGGLEVRLHPDISVEDMRVGKFLVVQGMRSRFFCMLTDVALGMANQRIIANPPNWEDTFLRDVLAGSGTFGTINLAPMLMFTPEVEEDFPSKNGKSANALVRAATKGLASFQPQTSTTMELLPVKTIPSHFSQVYEASEEDFRRVFGWEDDIHRKNFSIGKPLDMDVPVCIDLDRFVERSNGVFGKSGTGKSFLTRLLLAGIVRKNAGVNLIFDMHSEYGWQAVCEGKTYSTVKGLKQLFPDRVEVYTLDPASTKRRGVQNAQELYLSYDQIEVEDIRLCSRDLGLSEASLDNANILSAEFGKAWILQLINMTNEEIKMFCEEKRGHQGSITALQRKLLRLENLKYMRSACPQNYVNQILKTLEAGKNIVIEFGSQSDMLSYMLVTNMITRRIHQHYVGKAEQFLQSGNVVDKPNQLVITIEEAHRFLDPAIVASTIFGTIAREMRKYFVTLLVVDQRPSGIDNEVMSQIGTRVTALLNDEKDIEAIFTGVSGGTALRSVLAKLDSKQQALILGHAVPMPVVVRTRPYDEKFYAEIGDQIWEEKADDEVFAAAELAKADLGF
>NZ_AP018274.1|WP_096612601.1|2520925_2521867_-|glycosyltransferase-family-2-protein
MSRLLTIAIPTFNRAELLDKQLEWLSQAILGFENDCEILISDNCSTDNTQDIIKKWQNKLSNIIFISNRNTSNIGVMRNIMFCLNTAQSKYVWTIGDDDPIKNNTLSYIIDNLKKHPELSLLVLNYSRFNAISSQIIKERNFNITEEKIHDDARTFIEHNIKEGIFGFGFMTAQVYRTDTVKMALKKWQNSLNNLEMQVFWGAYCALQGSIKFSHDVFVEYTCGTNCLSDKKTWFKVYYADLVRVYTKLKEIGYSPEFCQKLIIRHFTHQHTLRILLGAIRRYPILGLKTAIPYLFVVLSNTFQLMLTRRQFS
>NZ_AP018274.1|WP_096612603.1|2523779_2524166_+|rhodanese-like-domain-containing-protein
MDEQIKHYQSKLEFETDSWDLKVALESGENILVIDARSSDAYQQEHIPGAINIPHRTMSEETTNHLDRTALVVTYCDGIGCNASTKGAMKMAKLGFRVKELIGGLDWWKRDGYKTNSSDATKSNACGC
>NZ_AP018274.1|WP_096612605.1|2524519_2525602_+|photosystem-II-q(b)-protein
MTATLQRRESANVWEKFCSWIASTDNRLYIGWFGVLMIPTLLAATTCFIIAFIAAPPVDIDGIREPVAGSLMYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVVFHFLIGVFCYMGREWELSYRLGMRPWICVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHQLGVAGVFGGSLFSAMHGSLVTSSLVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTSLGISTMAFNLNGFNFNQSVIDTQGRVINTWADVINRANLGMEVMHERNAHNFPLDLAAGDAAPVALTAPAING
>NZ_AP018274.1|WP_096613531.1|2526150_2527371_-|geranylgeranyl-reductase
MTLRVAVVGSGPAGSSAAEVLAKAGIETYLFERKLDNAKPCGGAIPLCMVSEFDLPADIIDRRVRKMKMISPSNREVDINLINQEEYIGMCRREVLDSFLRNRAAKLGATLINATVHKLDIPSNNTDPYTIHYVDHTEGGAQGIAKTLKVDAIIGADGANSRIAKEIDAGDYNYAIAFQERIRIPEDKMAYYNDLAEMYVGDDVSTDFYAWVFPKYDHVAVGTGTMHVNKASIKQLQAGIRARAAEKLEGGQIIKVEAHPIPEHPRPRRVVGRVALVGDAAGYVTKSSGEGIYFAAKSGRMCAETIVEFSNAGAKIPTENDLKVYLKRWDKKYGLTYKVLDILQNVFYRSDATREAFVEMCGDLDVQKLTFDSYLYKTVVPANPITQLKITAKTIASLLRGNALAP
>NZ_AP018274.1|WP_096612607.1|2527540_2528023_-|DUF4440-domain-containing-protein
MKKILFFSTWLSLTLALNLAIASTSPNQKITNCIHVTEDDVKTLFDRWNNSLRTRNPDIVVSNYAKNAILLPTVSNHWRTNSTEIREYFVKFIKNNPVGKIDNRIIKLSCNSVIDTGFYTFTFTTQGQKKTVLARYSFVYEYLNGKWLIVSHHSSKMPES
>NZ_AP018274.1|WP_096612609.1|2528390_2529797_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MSQQFATTGTIAAIATAIAPQQGSVGIVRLSGTEAVFIAQKLFYAPGKQVWESHRILYGYIRHPQTQQTIDEALLLIMESPRSYTREDVVEFHCHGGIMAVQQVLQLCIENGARLAQPGEFTLRAFLNGRLDLTQAESIADLVGAKSSQAAQTALAGLQGKLAQPIRQLRNQCLDILAEIEARIDFEDDLPPLDCNYIIQEFVKISGEINRILVTADTGELLRTGLKVAIVGRPNVGKSSLLNAWSRTDRAIVTDLPGTTRDVVESQLVVGGIPVQVLDTAGIRETEDTVEKIGVERSRKAAQAADLVILTLDASQGWTSEDQEIYEQVKHRPLILVINKIDLIDLLSPENIEAQYFIYPQEINKLVKTAAAKNQGIEDLEAAILETVKIKKVTAANIDFAINQRQAAALLQAKTSLAQVQKTIEQDLPFDFWTIDLRTAIHALGEITGEEVTESVLERIFSKFCIGK
>NZ_AP018274.1|WP_096612611.1|2529886_2530111_-|KTSC-domain-containing-protein
MELQQVESSMVRAVGYDETSETLEVVFSSGKIYKYFPVPKKIYDQLLAAESKGSYMQDAVIDCYQYRQIRKRSR
>NZ_AP018274.1|WP_096612613.1|2530266_2535399_-|hypothetical-protein
MVGKHPAAEGILAANDRALNSLRRAIAFSQGQFSLCLVGCNYGVLRKQMLQRLEEVLGEEYPIHKVTLSSNVISLYSTIHAELANKQPAALVILGLESVEELDDLLRTINHIRDEFRKRHPFPMVFWVNDELLRKLRRFAPDFTSWAATPIRFEMTTQELRQFLQDKTDTLFAQILDIGNVSDSKESPHKTLGEVWDYSSYEFRCAIQELQHRGIDLEPELDASLAFVSGLDDYANDKIDLAIEFFQQSLEFWQQEKTEKSAFSPSLPFTSSIPPNPPPPHLLRQGALLFYIGLCYFRLAERSHIEHRQRWQQAKSYFQQCLDVFEKAQRPDLMAQIIGLLAEVLQHLKEWDELQVVADKSEKLHHAFGTNCQLAYDFGFLAKVAVARENWGQASQLARVALWQLHEAKENSYSPPNLFPLLMGQVYRLTLAQALQNLSDGGSNPLPEYHKIAGEQLELASQELNAALVGSDFNYDVYRYIRLLRWLRSLYFESGLYLEAFIIRQKRRSVEQQYGLRAFIGAGRLQPQRHPKTPALSSPTSSGSVALEITASGRQRDIHNLIARVSRADHKLTIIHGPSGVGKSSTVTAGLVPALQQRAIGDQIAVPVVLQVYTDWVRELGKALGNAIVATKPVVMRKAALDTLPPYPATPITIDGVLELLQENARNSIITVLIFDQIEEFFSGCSLIQLQEFDHFLCVALNVAFVKVILSVREDYLHRLLEFKQLSGLEAINENLLDKNIRYQLNNFSREDAKTVIQGLTERSQYHLEPALVDALVEDLSAELGEVRPIELQVVGAQLQDERILSLSKYEQFRPNKLIERYLKELIRDCGPENERAALLVLYLLTDETKKRPFKTRAELAAELAELENVEKLELVLEILVRSGLVVLFPEVPERYQLIHDYLVDLIRILQQDELSLQEQVKKLRQQVQQSELEISRLNSELRHKKQAKLQDNYPQTGSDLLGELKELRKRDEVSRVERDRLLSEIEQQKLQAELIETEKQRQHQTRVNRLLKSALFASSMGMLLLIASIGMAFYQGRKAVIAASEAASVSSQALFTLGKDIDSLREGLRAARKLDQAIFPHPKTQQMVKTALYQATYGMRVREINRLEGHKSDINSVVISPDNLLIASASSDGTVNLWEKKGKKIHELKGHSRRANSVAFSPDSKIIVSGSADGTVRLWNIDGKLLQTIASGQKIVNSVAFSPDGEIIASAGADKTVRLWNRQGKLLKILSGHSDAVLSVAWAADGNAIASSSSDTTVKLWSRDGKLITTLPGSGEKNTVLSVAWSPDGRMLATASWDHLVRLWSRDGKLLNTLTGHKHVVSNVAFSPDGKTIASASWDRTVKLWNLNGTALETLKGHNDLVSSISFSRDGQMLASASRDTNIKLWRWNYMPLTSIKAHSQEVSQLSYSQQGDLLVSASEDHTVKIWSRDGKLLHQLVGHQKEVWDANLSPDGQFLATASEDNTVKLWSREGKLITTLTGHQEPVLSVDWSPNGERIATASADATVKLWSREGKFITTLTGHQDTVNWVSFSPDGNSIASASDDKTVKIWSKEGKLIRDLSGHSRSVFAVVWSNDGKLLASASLDSTAKLWSPEGKKLKTLTGNGESFITVSFSPDSQTIATLSEDKILLWNRQGNVELAVNAEDETFTTLTFTPDGKALVTGSSTGKVVFRDLADTEINKLLTRGCELLQDYLQNNTKVPKSDRSLCS

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Crispr_ID: NZ_AP018274_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP018274_6

2576325-2576724

Orphan

I-D,II-B

Consensus_repeat	Method
TATTGCAATTAAAAATAATCCCTATCAGGGATT-----------GAAAC	PILER-CR
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	CRT
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_AP018274_6

>merge|NZ_AP018274|6|2576325-2576724|PILER-CR,CRT,CRISPRCasFinder
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAACGGCTATCCCTAAGAATATTATTCGGCAATAAAAAATTGCAATTAAAAATAATCCCTATCAGGGATTGAAACTGCCTAAGAAAGCATCATCTGTGCGTGATTCATTATTGCAATTAAAAATAATCCCTATCAGGGATTGAAACCAACCTTCCATTCTCTTAGAGTTACGTTGCGATCGCGTGTCTATTGCAATTAAAAATAATCCCTATCAGGGATTGAAACAGGAAGAAAAGACAATAAACTGTCTTTAATTTCTATTGCAATTAAAAATAATCCCTATCAGGGATTGAAACTTATTTTCTAAATTAAATAAAGATTTAGATTATATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC

>NZ_AP018274|6|2|2576325-2576724|PILER-CR
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	GGCTATCCCTAAGAATATTATTCGGCAATAAAA
AATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	TGCCTAAGAAAGCATCATCTGTGCGTGATTCAT
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	CAACCTTCCATTCTCTTAGAGTTACGTTGCGATCGCGTGTC
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	AGGAAGAAAAGACAATAAACTGTCTTTAATTTC
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	TTATTTTCTAAATTAAATAAAGATTTAGATTA
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC

>NZ_AP018274|6|2|2576325-2576724|CRT
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	GGCTATCCCTAAGAATATTATTCGGCAATAAAA
AATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	TGCCTAAGAAAGCATCATCTGTGCGTGATTCAT
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	CAACCTTCCATTCTCTTAGAGTTACGTTGCGATCGCGTGTC
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	AGGAAGAAAAGACAATAAACTGTCTTTAATTTC
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	TTATTTTCTAAATTAAATAAAGATTTAGATTA
TATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC

>NZ_AP018274|6|6|2576326-2576724|CRISPRCasFinder
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	GGCTATCCCTAAGAATATTATTCGGCAATAAAAA
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	TGCCTAAGAAAGCATCATCTGTGCGTGATTCATT
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	CAACCTTCCATTCTCTTAGAGTTACGTTGCGATCGCGTGTCT
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	AGGAAGAAAAGACAATAAACTGTCTTTAATTTCT
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC	TTATTTTCTAAATTAAATAAAGATTTAGATTAT
ATTGCAATTAAAAATAATCCCTATCAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP018274.1\|WP_096612682.1\|2581905_2584284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374761
NZ_AP018274.1\|WP_096612667.1\|2571412_2572324_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612680.1\|2581166_2581847_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|250888
NZ_AP018274.1\|WP_096612684.1\|2584437_2586918_-\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018274.1\|WP_096612661.1\|2566993_2567479_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612688.1\|2593985_2596484_-\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018274.1\|WP_096612665.1\|2568340_2569786_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226196
NZ_AP018274.1\|WP_096612669.1\|2572701_2573874_+\|phosphonopyruvate-decarboxylase	unknown	unknown	gnl\|CDD\|274508
NZ_AP018274.1\|WP_096609659.1\|2589498_2589750_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612659.1\|2565228_2566590_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379252
NZ_AP018274.1\|WP_096613539.1\|2591512_2593324_-\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_AP018274.1\|WP_096612671.1\|2573947_2575027_+\|2-aminoethylphosphonate--pyruvate-transaminase	unknown	unknown	gnl\|CDD\|274512
NZ_AP018274.1\|WP_096613537.1\|2569995_2571342_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|224699
NZ_AP018274.1\|WP_096612673.1\|2575269_2575800_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612675.1\|2576801_2579267_-\|S-layer-family-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018274.1\|WP_096613173.1\|2588191_2589427_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP018274.1\|WP_096612663.1\|2567671_2567983_-\|DUF4282-domain-containing-protein	unknown	unknown	gnl\|CDD\|379475
NZ_AP018274.1\|WP_096612677.1\|2579415_2581053_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|250888
NZ_AP018274.1\|WP_096612686.1\|2589829_2591401_-\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|368641
NZ_AP018274.1\|WP_096612657.1\|2564403_2565075_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777

Protein	Function_ID	Function_description	E-value
NZ_AP018274.1\|WP_096612682.1\|2581905_2584284_-\|hypothetical-protein	gnl\|CDD\|374761	pfam16734, Pilin_GH, Type IV pilin-like G and H, putative. Pilin_GH is a family from Cyanobacteria. All the proteins are putatively annotated as being general secretion pathway proteins G and H, and are likely to be pilins of the type IV secretory pathway.	3.24805e-15
NZ_AP018274.1\|WP_096612680.1\|2581166_2581847_-\|hypothetical-protein	gnl\|CDD\|250888	pfam01816, LRV, Leucine rich repeat variant. The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.	0.00117504
NZ_AP018274.1\|WP_096612684.1\|2584437_2586918_-\|S-layer-family-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	3.73164e-27
NZ_AP018274.1\|WP_096612688.1\|2593985_2596484_-\|S-layer-family-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	6.271e-26
NZ_AP018274.1\|WP_096612665.1\|2568340_2569786_-\|hypothetical-protein	gnl\|CDD\|226196	COG3670, COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	4.27294e-178
NZ_AP018274.1\|WP_096612669.1\|2572701_2573874_+\|phosphonopyruvate-decarboxylase	gnl\|CDD\|274508	TIGR03297, Ppyr-DeCO2ase, phosphonopyruvate decarboxylase. This family consists of examples of phosphonopyruvate an decarboxylase enzyme that produces phosphonoacetaldehyde (Pald), the second step in the biosynthesis phosphonate-containing compounds. Since the preceding enzymate step, PEP phosphomutase (AepX, TIGR02320) favors the substrate PEP energetically, the decarboxylase is required to drive the reaction in the direction of phosphonate production. Pald is a precursor of natural products including antibiotics like bialaphos and phosphonothricin in Streptomyces species, phosphonate-modified molecules such as the polysaccharide B of Bacteroides fragilis, the phosphonolipids of Tetrahymena pyroformis, the glycosylinositolphospholipids of Trypanosoma cruzi. This gene generally occurs in prokaryotic organisms adjacent to the gene for AepX. Most often an aminotansferase (aepZ) is also present which leads to the production of the most common phosphonate compound, 2-aminoethylphosphonate (AEP).	3.7941e-154
NZ_AP018274.1\|WP_096612659.1\|2565228_2566590_-\|hypothetical-protein	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	5.9882e-43
NZ_AP018274.1\|WP_096613539.1\|2591512_2593324_-\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.51011e-116
NZ_AP018274.1\|WP_096612671.1\|2573947_2575027_+\|2-aminoethylphosphonate--pyruvate-transaminase	gnl\|CDD\|274512	TIGR03301, PhnW-AepZ, 2-aminoethylphosphonate aminotransferase. This family includes a number of 2-aminoethylphosphonate aminotransferases, some of which are indicated to operate in the catabolism of 2-aminoethylphosphonate (AEP) and others which are involved in the biosynthesis of the same compound. The catabolic enzyme (PhnW) is known to use pyruvate:alanine as the transfer partner and is modeled by the equivalog-level model (TIGR02326). The PhnW family is apparently a branch of a larger tree including genes (AepZ) adjacent to others responsible for the biosynthesis of phosphonoacetaldehyde. The identity of the transfer partner is unknown for these enzymes and considering the reversed flux compared to PhnW, it may very well be different.	7.83901e-136
NZ_AP018274.1\|WP_096613537.1\|2569995_2571342_+\|alkaline-phosphatase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	9.47094e-43
NZ_AP018274.1\|WP_096612675.1\|2576801_2579267_-\|S-layer-family-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	1.0778e-25
NZ_AP018274.1\|WP_096612663.1\|2567671_2567983_-\|DUF4282-domain-containing-protein	gnl\|CDD\|379475	pfam14110, DUF4282, Domain of unknown function (DUF4282). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 93 and 155 amino acids in length. There is a single completely conserved residue E that may be functionally important.	3.04238e-13
NZ_AP018274.1\|WP_096612677.1\|2579415_2581053_-\|hypothetical-protein	gnl\|CDD\|250888	pfam01816, LRV, Leucine rich repeat variant. The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.	0.0069986
NZ_AP018274.1\|WP_096612686.1\|2589829_2591401_-\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	9.40436e-25
NZ_AP018274.1\|WP_096612657.1\|2564403_2565075_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	1.33072e-38

>NZ_AP018274.1|WP_096612673.1|2575269_2575800_-|hypothetical-protein
MKKIIPLDNFTILTPDTTDVVQQNLKQCLFYRGSISEQGFKITRNLYRSVFTLIKGRFEAQSHQTAVHIQISLHPFLIAPLGLFFLFWYGIAVPGMFESAKYIYAKPPRVTIPDDGNVAQSAIAAISSAPEGTMPTHLAAIYLGLPIVLLIVFVVSFWVDAKQIRRELTQIIRGKI
>NZ_AP018274.1|WP_096612671.1|2573947_2575027_+|2-aminoethylphosphonate--pyruvate-transaminase
MILLNPGPVTLSDRVRNALLQPDLCHREVEFSQLQTKIREKLLQIYGLQARHWVTVLLTGSGTAAVEAMLTSLVPRSGRLLVVENGVYGERMAKIAQIHRLDYSIVHHPWGEAIDFQLLTEFLDSHLDITHLAVVHHETTTGRLNNLKELARICRDRHIKILVDAVSSFGAEEIDFAAWGITACAATANKCLHGVPGTAFVILKRNALPPIEIVPRTLYLDLGTYCRQQDAGGTPFTQSPQIFYALAEALEELEETGGWRARKAHYTQLANLVREGLTAIGIEPILPQEDSSIVLNAYKLPKNFTYEEFHDRLKSAGYIIYAGQGNLSKSIFRVSTMGAICQADMERFLEVIKKMLNRY
>NZ_AP018274.1|WP_096612669.1|2572701_2573874_+|phosphonopyruvate-decarboxylase
MIQAEQFVEAARKLGFEWYTGVPCSFLTPFINYVINDTQLTYISSANEGDALATAAGVVIGGKRAVVMMQNSGLGNAVSPLTSLTYIFKIPVLIICTLRGDVNLKDEPQHELMGQITDKLLETMGIPWEYFPDKASEIAAVLQRAHNYMQQEHRPYALIMRKGTVAPHALQTKEGVGGWGEGGMGRGGEVGLSQSVNSLNTRHQALEAIVQQTNPEDTVIIATTGYTGRELFALSDRPNHLYVVGSMGCASSLALGLSLARPDLTVVVIDGDGAALMRMGNFATIGAYAGANFIHILLDNEVHDSTGAQATVSRGVSFAKIAEACSYGTTLMGSELGLIEALFMEKTQNRPKFAHLKIRPGTLENLPRPNMSPAAVLQRLMNHIHRKREK
>NZ_AP018274.1|WP_096612667.1|2571412_2572324_-|hypothetical-protein
MKASAKFDFEDERFNAPPSQVIPWCQMINPRYNDDGVQSHGLAIKLDNAQAVGFEPDDNWQEVEHEFSSGVEKVYLSTTPKIVIVRRGPLSVKDRETGTKLGTLRDNYDAFLADKLKFKTFTRYLIFLVGENKKFLHESPLQLTLHGAAGASFSKTYCEYQQGRASGGFVVELERAYASFRKQPFMPKGALFHAHGIFCPIIESEERGIHPNTVLVASTVDYKHPTVSTLTQYLIASDSPESALITRAFEDYKEFGKEQVRTEANGNSGNNANNGNYNKMAIAGVASSSYVYADDDDFAYPPY
>NZ_AP018274.1|WP_096613537.1|2569995_2571342_+|alkaline-phosphatase
MRHLCQFISLAALSLVVITSCGEAYSNASNSQQGNVIFIHPDGTSPSHWGAARMLHYGPDGRLNWDKMSHMGVYLGHMKNQLTATSNGGAVTHATGVKVNADSFGLDEKLQPVVAASGKTQTIIQEAIASGKGTAIINSGMIHEPGTAAFVAKEPNRRQFAEITKQIVESNVDVILGGGEMWYLPKGTAGKHSTAQQSQRTDGVNLIEVAKKKGYTVVYTRQELLKLPANTKKVLGVFAADDTYNDATEEDLKKDNLPLYVPTAPTVAEMLDVTLKILSAKNKNFIVVLEEEGTDNFANYNNAPGTIEAMKRADDAVGIAMKYIENNPNTLLLTAADSDAGGLEVIGVTEKDFPLNKPIPAKSNNGAPWDGKEGTSTPPFVSAANQEGKSFPFAIGWSSGGDNVGAIVSKAQGLNADKLPSTLDNTDIYRLMYRTLFGKEIAPYRKEK
>NZ_AP018274.1|WP_096612665.1|2568340_2569786_-|hypothetical-protein
MTTASNPISSQNAWAKPILETAKEFPHTPITTKEGKIPSGLRGTLYRNAPGRLERSGIRMGHWFDGDGAILAVNFADNGASATLRYVQTKGYQEEAAANQLIYGNYGTVAPGSIFNKLFKGTKNSANTSVLALPDKLLALWEGGKPHALNLQTLETLGEDDLGMLTNGLAYSAHYKQDTQTGEIFNFGISPGLNATLHIYKSTASGDIIQKAVHQLDGISLTHDFVLAGQYLIFFLPPLRLNLLSVITGKSCYSDAFRWQPSKGTQFLVIDRETLKLVSRGETEPWFQWHFCNGYVDTSGTVIIDIARYEDFHTNQFLKEVATGKTHTIAKSHLSRVYLNPQTGKVLKIEKIFDNHCEFPSVPPENVGKESRHAYLSTFRNPAEMKGELLNAIAHYDYSKDVLTIANLGSNHYPSEPIYVQDKENPLQAWILTVVYNGTEDGSEVWIYDAQKLNEEPICKLKLPDVVPHSFHGTWKQSLTK
>NZ_AP018274.1|WP_096612663.1|2567671_2567983_-|DUF4282-domain-containing-protein
MASNKNFFSQLFDFSFSEFLALKIVGVLYGIGMFFAGIFTLGIAVNSFRVGFASGVVGLILAPIIFLLYILFIRIALEGMIVAFRTAENTARIAENTKHLRNP
>NZ_AP018274.1|WP_096612661.1|2566993_2567479_+|hypothetical-protein
MIHHISIAARQPQHVAQVLAEVLKANVTPFPPHPGSYLVIPFDEQGTAIEVYPLGSEILPGDADEQCHFRINDRASEFTATHAAISVPVSREEIEEIGKREGWRVVYCDRESFFDVIEFWVENRLMIEFLTPQMTSKYLKFATNRENVQLFMAAPALSISN
>NZ_AP018274.1|WP_096612659.1|2565228_2566590_-|hypothetical-protein
MPDILALLECLQRYTTRTTLRRWSRIISAMLAMSGRITMLGISRWCGKGGSYRTIQRFFAHSLPWAGLFWVFFREHIFCQKETYLLAGDEVVVSKAGKKSYGVDKFYSSLHDKPIQGLSFFALSLVSIEQRKAFPIRIEQVIKPKVEKQAKLTEETKKPKEKPNQEVPKKKGGRPKGSKNKDKTEVVFTSELLRIRILIQDLLKKLSKFLPLTYLVLDGHFGNNNAVVMTRQMGLQLISKMRYDSALYIPYENPDPSRKCRRKYGDRIDYSFIPDKFLKKTETVENIRTDFYQTQLLHKEFSQTLNVVIIVRTNIVTSHRTHAVLFSTELSLSYVHVIDYYSLRFQIEFNFRDAKQFFGLEDFMNVGKNAVTNAANLAFFMVNISQVLLSHFRKFNPDFSITDLKAIFRGYKYVEETIKLLPEKPDPVLLANIFHRVTNLGRIHPADPCSSSS
>NZ_AP018274.1|WP_096612657.1|2564403_2565075_+|rhomboid-family-intramembrane-serine-protease
MFPLYDENPTRITPYLTYGLIGMNVLIFFHELSLGRQIEPFFQTYAVIPAELKNNFAGEWTTLFTSQFLHGGWWHLLSNMLYLWVFGNNIEDRMGHFKYLIFYLSCGALAALCQCFIDFNSIVPSLGASGAISGILGAYLIRFPQAQVMTLAFLFFFVTTFRVPAMLLIGLFVVQNVVSGLASLQAAANMSVESGGVAYWAHIGGFVFGIILGPMFGLFRRDD
>NZ_AP018274.1|WP_096612675.1|2576801_2579267_-|S-layer-family-protein
MRVTFTLLGLIGGMLVCAICNNYVKAQVIPDGTLKTTVSQSGNNFTITNGDRIGNNLFHSFSQFSVPSQGSAFFNNASDIQNIFSRVTGGSVSNIDGLIKANGSTNLFLLNPSGIIFGADAKLNIGGSFVGTTAESIKFADGNEFSAINPQTQSLLSMNVPIGLQMGSNPGAIAVQGLGHNARLSDSFQVSGLNIETRGLQVQPGKTLALVGRNVTLDGALLSAPGGLIELGSIASGNVVLNSVPQGFAFSYPNTSSFSNIQIRRRALASTRNLNGGNGGAIQIQGKQISIQDGSLVLVQNRSNQTAGDIRISATESLDIIGKSPDFQSSSSLVNETISSGAAGNIIINTPQLNIDRGGYIFNRTFSAAPGGNILVNSDNVRVNGFASGDPSAFRAISQILASSYGNGKGGNIFVSTQNLSVSAGGNIAARPYASGNGGDVNVKADTIEVSSRGTPNGSYFSLISTATFGAGNAGNLAINTRKLSVQAGGRVSASSIVLGNAGSLNINASESIDVSGIKDAANPSYIGTAVRPVGLFAQISRANAGNTTINAPTLNITDGATVFVQNTGSGTAGVLQINANTLKLDNEASISASTTAGEGGNINLQLRDLLLMRHSSFINAEAGGSGNGGNITINAPNIVGLENSDIIANAVQGKGGNIQIATQGIIGLQYRDLLNPRELLTNDITASSQFNLSGTVKINNIGVDPNSGLVELPANLTDPSQKIATSCADNSGSSFIATGRGGIPQNPSQELRSDRTWSDIRDISAFRKNNSVIGEIPTTPETLVQATSWHRNVQGKIELVADKPSTQMQQQLTCAAVSKS
>NZ_AP018274.1|WP_096612677.1|2579415_2581053_-|hypothetical-protein
MRNPSLPRSIVNNFFQERFLATNPHTEVEKLRELCVSKWSFIRARVAKHPNLELSDLKKLARSPELKIRVAVASHPRADVRILKHLTGDRSILVRRAVALNSQTPQECLEILSRDRNVYVRANVAKNPCTPLEILLLLSQDKDSRIVKNIAFNPAIPQELRSQLQLEIPQREPEHIYLWRRLFSGPYEYNGIPIKELWSQEQYDLAASAITPIPQLLELIKITPNDIYWEAVHNICQQVICNPDISSELLLEILDIRSIDIYAAVASHPHISDAVCNRIVNNEFRDYRLSLLMLQNSNISLDFIEKLLSHRKSEVRQFALKKHQQIFADNDIKNIFLTQYNAATCEQTPLEKLTQLSKHKSVLIREAVAKNPRIIKAYSFCTKIRTCLERLAKDKNQSVRIAVANNINTPIHILEILAKSYQYEPGVHTRYQRHHNRKEHKVFVIAVKKLMQIAPEIASKYLVQYIEPNCHTLDSIPFRLAILQNFPVPIEYLAKKIKTLHLFPWYERYLIVQNPQASTEILQMFLKDVNRVVRAAAKARLTETQ
>NZ_AP018274.1|WP_096612680.1|2581166_2581847_-|hypothetical-protein
MVELMQVSNQVAITAANSIHTAPELLTELAGHEDIQVRQAVAGNPNTPTDVLLQLAEEFPQEFVKNPVLPLLQLENPEFHKLIPYSVIQNILACEGAPQEWLRLFATYVCYDYLLAIVHNPQASKQVLQLVAENEYCGAVIHELIELHVNIAGEMKSGWQEYADNKLQYIQDILKSEYYHPRDKGQYYKFTFWELGLSCNFVKLQNMYERLSLNVPTLHQKNYGNY
>NZ_AP018274.1|WP_096612682.1|2581905_2584284_-|hypothetical-protein
MKLPLFSLFPSLSLVLCLTLMPNVRANAIANQQNQQISVQEIATRKEIRTLLGSVGRAQQAHFLENHRFATQIKQLGLGDDIQNSIPGYQWQVFTDKKAEIAAITVLSPKQSGSRTYVNFVNLAISSAGEKITITTLCESKQNQRIIPKVPTKILKNQDTMKCPSGFRKFELSQDEEKIYEQVKKEKELVSVVGIFNSLQKQYYSQNQVFADRNEELLGFDINKIQPQLKSSFKLLPIQDTKQGIITIATFPNQNYKSYLGIVKTTEKTSGKVESLICEVPQQESIDLQKLKKLSLNILLNCPPGSKEVSLSSEEIAYVNEGKEKLQNYKAEIAEIKQPKKTPFLKAADKLAQEGKYLEALEKYYLASGALGINEYDILLEFSGESTFNPTRDALFKKIELVLQAAKPLIEQQKKEIQSEMYSVFDRFPNEKNHTGQKIKEIAASQLGFNILTTPQQELKIPANKSEEFSEIAESLREYFNDKSKKPNQKLSDNLRKYTNKNRRAIATIRDLLLNGEIPRWGTDYKWVKEGDFAASAPSYLNIVNLQRLLAIDILDQQQQGNNPEMLKSLEASWRLSESLQNDPSLLGQLVNIIIRRSQIQVMEKLDNLPVVWQQRLLAYDYTKSMIQALKVEAFSQLQGLDKIITPEKDTAIAKLYRNWYGVNTYKLNQAFYAEVERQQNNLCSVDIKALEKQYFNSESSISPSYVNQILKAQHLMLESEMMQKVLQIKAEIAQGKTVPNYLLNIPSSICSTNKWVYKSFPNAKWSISLDKQPTWQSRIARSPLTYTGDRP
>NZ_AP018274.1|WP_096612684.1|2584437_2586918_-|S-layer-family-protein
MGNISVWFGLIGGIITGAIWSNSVNAQVVSDGTLKTTVSQSGNNFTITNGDRIGNNLFHSFSQFSIPTNGSALFNNTADVQNIFSRVTGGSVSNIDGLIQANGSANLFLLNPSGIIFGQNATLNIGGSFVGTTANSIKFADGVEFSATNPGATPLLTMSVPIGLQMGSNPTPITVQGTGHALTAVSTVAPITQNPSSSELRVKPGKTLALVGGSLNLTGATLNAPEGRLELGSLDGVGLVSLNPISQGYQLGYESGQSFADIQLTQKSFLSIGALPTVGALNAGSVQLQGKHIQISDGSIIFSKNLGNVAGGEFFLQASEGIDIVGTTANAQIRSGIRSEGLNTGAGSPIRIITPHLTISQGAGVNTNAFGLAASGDILIDAGTVELSGFSPINPTGVTSLTTSSRTAKSAGNLSINSNNLLVSQGAAISSVALASGSTGQVTIRSKNTTVTGDNPAGLYSNISAITYGTGDAQTLTLDTNRLQLLNGGVVSTTSFLIGKAGNLNINATESILIDGHSQANNSSINSAVLIPPSLLQKLFNLPNILSANAGTVNVSTPNLTLKNGGVVSVTNQGTGDGGNIKIAVSKMFLDNQGSIQAQTTSGEGGNITSQVSELLLLRHNSLISATSAGTGNGGNININAPVIAGLENSDIVANAVKGRGGNIDITTQGIIGLEFRNTLTPRVDLTNDITASSEFNVNGTVQVNTIGVDPNSGLVELPANITDPSQQIATGCADSSGSSFIATGRGGIPQNPNQDVKSDRTWSDVRDISAFRQTQPVQAKIPTTPETLVQATSWHRNAQGKIELVADKPSTPVQQQLTCAAVPKS
>NZ_AP018274.1|WP_096613173.1|2588191_2589427_-|hypothetical-protein
MECGISFRGVEKVFELFNNYEEQATPSFSCVRKWLARIGIYELTKEKEYRDDWIFIVDLTLELGKQKALVILGVSQQHIEENVMKQKRGLAHEDVKIFGLEIMDSTKGEIIESKLEKISQKVGVPVQIVADNGSDLARGIKLYQQNHPDIIYTHDVTHAMALLLKYQLDSDERYQSFIQKCNISRQKLQQTDLSFLSPPTQRSQCRFFNVERLTNWGIKLLNSSPDTLIKLMPDSDPSLITQKIVDKLGWLVDYESDLIQWNQMVSLTRGVETQLKQSGISHKTLDFFEQNKVIFDDNSLQKLQQSILGYLSVQCRKIKNQSTFLATSDVIESLFGKYKQFSARCPFKEMGQMLLTICLSTMNLTTALIKNALETISFSDVEAWLSEVFGQSTLSKRKTLFSGDCDDIKSA
>NZ_AP018274.1|WP_096609659.1|2589498_2589750_-|hypothetical-protein
MQEFKSPVSRLARLFQKGRDNWKEKALLKQKKIRALEIKVRDLLDSREEWKNRALMAESKLKELNIEGDLDEKKRKFKSKQKS
>NZ_AP018274.1|WP_096612686.1|2589829_2591401_-|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MKAVPFLLIVTTGLLIPGIMRSATAQVVSDGTTNTTVNSSGNNFTILNGIDKGNNLFHSFSNFSVPTNGAARFDLVNTPNITTIFSRVTGGNISNIDGLIQTLNANNNAVSLFLMNPNGIVFGENAKLDISGSFVGTTANSIKFADGVEFSAVNSSEPPLLTMSVPVGLQMGINAGAIQVQGTPANNPQFRTPTLSMKANQTLALIGGQIDVNSANISAPDSHVELWAMQNGTVNIPTFGNWQLASSSLSPTWGTITLQQSSSIDTSGANGGAINIRGQGLTLQEGSNIGSATGTNGQGEGITVQTTEFVNLLGASHPSNVVFPGLNTSVRGGMATAGNITVETPRLQIDNGGWLSSVNMVTNFSALSSQPIRNSKTGNIMVRATEIDIRGYTPFINPATRAVVSSAITTLTGGTQNESGAITVEAERIRLQDGGRISTDLFGLLAPASGRAGNIFVTASQSLDILGASPANATSAIISSINILANGQGGNVTVNTGQLRLAKGGTISSQITGNPNVAIAGRG
>NZ_AP018274.1|WP_096613539.1|2591512_2593324_-|group-II-intron-reverse-transcriptase/maturase
MSNTSFKTTGEWRSINWRKLERRVYKLQKRIYRASQRGDVKAYRRLQKTLMNSWSARALAVRRVTQDNKGKKTAGVDGVKSLTPKQRLALIDKLKLGSKVNPTRRVWIPKPGKDEKRPLGIPTMKDRALQALTLQALEPEWEARFEPNSYGFRAGRSCHDAIEAIFNCIRYKPKFVLDADIASCFDRIDHSALLKKLSTSPTIRRQIRAWLKAGVIDGKQLFPTSEGTPQGGTNSPLLANIALHGMENRIKQAFPKGTILKKGKYSGYQPGAMLIRYADDLVILHEDITVVQKCREIMEEWLKDYGLELKPSKTRLIHTLSTYEGQKPGFDFLGFNIRQFSKGKHHTGKNTKGEKLGFKTIITPSQEKVKAHYDHLARVIDAHKAAPQAALIKQLNPIIRGWANYFATVISKEIYAFLDNLVYLKLVSWAKFRHPKKSCFWVSKKYWHSIDGDNWVFATKEAGENQVRLLDHTRIKIARHIKVIGVASPYDGNLIYWSTRMGNNPEMPKRVASLLKWQKGKCAHCGLFFRENDVMEIDHIIPKSQGGKDEYKNWQLLHRHCHDTKTAEDSSPGTQSGCNSTKPKPPSELNWFWEEDMLVMRYT
>NZ_AP018274.1|WP_096612688.1|2593985_2596484_-|S-layer-family-protein
MKTITFLLILTTGLLTPGIMRSAMAQIASDGTTNTIVNPSGNNFTILNGIEKGNNLFHSFSNFSVPTSGAAIFDLTNTPNITTIFSRVTGGNISNIDGLIQTLNANNSVSLFLMNPNGIMFGQNAKLDIGGSFVGTTANSIKFSDGTEFSAVDSNTTPLLTMNVPVGLQMGSNPGAITVENTGHLITIGFFAPADRSNNPIGLQVGAGNTLALIGGAVNFSSGIVTTNGGGHLEVGSVSAGQVKLNSTSTGLVGDYSAVKQFNDINLAQQSLLDASGSGGSIQLQGRNISFAEGSGALLQNFGTQQSSQGITINATGSINLSGNTSYGKLGSLIQIDNLGITQTGDINLSAAQLSLKDGAHIHNWTFTPIPGGNITANVAGAIAIEGFAPTNPLVSTSITSITLNSGKAGDITISSDNLRILNSGSISTISTGSGQAGILRFNVADLVEIAGNNPFTALSSSVISSASNTGDSGSTFINTSRLVIRDSGILGSSTVASGAAGSVTVNASESVDVRGKGSGSILPARIASSAEILDPVTQAILGLLAIPTGNAGSLSIDTPLLRVTDGGFVTVKNDGPGKAGDLQINANSIFLNNQGSITASTASGDGGNIRLKLQDYLLMRQESLISATANGDGDGGNLSINVPIAVGLENSDIIANAVEGRGGNINITTQGIIGLAFRNTLTPRIDQTNDITASSQFNVNGDVQINNFGVNPNSGLVELPGNVTDPSQKIATGCADTSGSSFIATGRGGIPQNPSQEVRSDRTWSDIRDISAFRQNQPVQAKISTTPEVPTETFTQATSWHRNAQGKIELVADKVSTNMQKALTCAAVPKS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP018274_1	1.1\|1244029\|34\|NZ_AP018274\|PILER-CR,CRT	1244029-1244062	34	NZ_LR214952	Mycoplasma neurolyticum strain NCTC10166 plasmid 2	17500-17533	6	0.824
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	LR214964	Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10	16633-16664	6	0.812
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	MN693026	Marine virus AFVG_117M72, complete genome	62645-62676	6	0.812
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	MH319754	Marine virus AG-345-L05 Ga0172272_11 genomic sequence	92607-92638	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP004877	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB431, complete sequence	135885-135916	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP031069	Bacillus sp. JAS24-2 plasmid pl626, complete sequence	323487-323518	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011350	Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence	120180-120211	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP022446	Bacillus cereus C1L plasmid pC1L1, complete sequence	81646-81677	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP044979	Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence	236882-236913	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP007616	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB400, complete sequence	222744-222775	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP004860	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB422, complete sequence	155679-155710	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP007513	Bacillus bombysepticus plasmid pBb, complete genome	388879-388910	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	CP046512	Bacillus cereus strain JHU plasmid p1, complete sequence	179618-179649	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP042875	Bacillus cereus strain 09 plasmid unnamed1, complete sequence	11971-12002	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011154	Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence	15292-15323	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011152	Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence	531592-531623	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	114924-114955	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NC_020385	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence	104634-104665	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP050184	Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence	148673-148704	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP021062	Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence	330224-330255	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP014284	Bacillus thuringiensis strain Bt185 plasmid pBT1850294, complete sequence	91811-91842	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	826957-826988	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP032609	Bacillus thuringiensis strain QZL38 plasmid p.2, complete sequence	183712-183743	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP023312	Vibrio anguillarum strain VIB12 isolate Sea bass plasmid p292, complete sequence	252343-252374	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	AY082070	Bacteriophage phi3626, complete genome	8740-8771	7	0.781
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NC_003524	Clostridium phage phi3626, complete genome	8740-8771	7	0.781
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	LR214964	Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10	16633-16665	7	0.788
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	MN694459	Marine virus AFVG_250M532, complete genome	15818-15849	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	76465-76496	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	49794-49825	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	202889-202920	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP013700	Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence	125928-125959	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	AP014182	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S41-C49, * SEQUENCING IN PROGRESS *	5746-5777	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	AP014181	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S40-C70, * SEQUENCING IN PROGRESS *	8175-8206	8	0.75
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	AP014183	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S42-C67, * SEQUENCING IN PROGRESS *	30512-30543	8	0.75
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	MH319754	Marine virus AG-345-L05 Ga0172272_11 genomic sequence	92606-92638	8	0.758
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	MN694459	Marine virus AFVG_250M532, complete genome	15818-15850	8	0.758
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	MT782071	Escherichia phage JN02, complete genome	29315-29346	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	KY703222	Escherichia phage phiC120, complete genome	118061-118092	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	MN693034	Marine virus AFVG_117M74, complete genome	881-912	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP017256	Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence	40420-40451	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	2840-2871	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	9258-9289	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	255385-255416	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP011146	Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence	258938-258969	9	0.719
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	MT774389	CrAssphage cr116_1, complete genome	99438-99469	9	0.719
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	MN693034	Marine virus AFVG_117M74, complete genome	881-913	9	0.727
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NC_017472	Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence	74361-74392	10	0.688
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP031668	Staphylococcus aureus strain 199 plasmid pPS00120.1A.1, complete sequence	8582-8613	10	0.688
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_CP031671	Staphylococcus aureus strain 64 plasmid pPS00119.1A.1, complete sequence	8583-8614	10	0.688
NZ_AP018274_6	6.5\|2576655\|32\|NZ_AP018274\|PILER-CR,CRT	2576655-2576686	32	NZ_LR130510	Staphylococcus aureus strain BPH2760 isolate BPH2760 plasmid 2	5482-5513	10	0.688
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	MT782071	Escherichia phage JN02, complete genome	29314-29346	10	0.697
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	KY703222	Escherichia phage phiC120, complete genome	118060-118092	10	0.697
NZ_AP018274_6	6.10\|2576655\|33\|NZ_AP018274\|CRISPRCasFinder	2576655-2576687	33	NC_017472	Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence	74361-74393	11	0.667

1. spacer 1.1|1244029|34|NZ_AP018274|PILER-CR,CRT matches to NZ_LR214952 (Mycoplasma neurolyticum strain NCTC10166 plasmid 2) position: , mismatch: 6, identity: 0.824

ctaagttttaaattcagttctttttatgctattt-	CRISPR spacer
ttaagttttaaattaagttttttttct-ttattta	Protospacer
.************* ****.***** * .*****

2. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to LR214964 (Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10) position: , mismatch: 6, identity: 0.812

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttaatttctaaattaaataaagatgctgctca	Protospacer
*** ******************** . * *.*

3. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to MN693026 (Marine virus AFVG_117M72, complete genome) position: , mismatch: 6, identity: 0.812

ttattttct-aaattaaataaagatttagatta	CRISPR spacer
-tattagatgaaattaaacaaaaatttagatta	Protospacer
 ****   * ********.***.**********

4. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to MH319754 (Marine virus AG-345-L05 Ga0172272_11 genomic sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
atattttttaatttaaataaagatttattctt	Protospacer
 ******.*** ***************  .*

5. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP004877 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB431, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

6. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP031069 (Bacillus sp. JAS24-2 plasmid pl626, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

7. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011350 (Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

8. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP022446 (Bacillus cereus C1L plasmid pC1L1, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

9. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP044979 (Bacillus thuringiensis strain BT62 plasmid pBT62A, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

10. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP007616 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB400, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

11. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP004860 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB422, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

12. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP007513 (Bacillus bombysepticus plasmid pBb, complete genome) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

13. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to CP046512 (Bacillus cereus strain JHU plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

14. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP042875 (Bacillus cereus strain 09 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

15. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011154 (Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

16. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011152 (Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

17. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

18. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NC_020385 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

19. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP050184 (Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

20. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP021062 (Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gtggtttctaaatcaaataaagatttatacaa	Protospacer
 *. *********.************* *. *

21. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP014284 (Bacillus thuringiensis strain Bt185 plasmid pBT1850294, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
atctattataaattaaataaagaattaggtga	Protospacer
 * * ** *************** ****.* *

22. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttagataataaattaaaaaaatatttagattt	Protospacer
***  *  ********* *** *********

23. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP032609 (Bacillus thuringiensis strain QZL38 plasmid p.2, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
atctattataaattaaataaagaattaggtga	Protospacer
 * * ** *************** ****.* *

24. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP023312 (Vibrio anguillarum strain VIB12 isolate Sea bass plasmid p292, complete sequence) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tcaatttctcaattaaataacgatttaaagca	Protospacer
*.* ***** ********** ******.* .*

25. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to AY082070 (Bacteriophage phi3626, complete genome) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tacttaactaaattaaatagtgatttagataa	Protospacer
*  **  ************. ********* *

26. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NC_003524 (Clostridium phage phi3626, complete genome) position: , mismatch: 7, identity: 0.781

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tacttaactaaattaaatagtgatttagataa	Protospacer
*  **  ************. ********* *

27. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to LR214964 (Mycoplasma fermentans strain NCTC10117 genome assembly, plasmid: 10) position: , mismatch: 7, identity: 0.788

ttattttctaaattaaataaagatttagattat	CRISPR spacer
ttaatttctaaattaaataaagatgctgctcaa	Protospacer
*** ******************** . * *.*

28. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to MN694459 (Marine virus AFVG_250M532, complete genome) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
atattttcaaaattaaataaaaattcatcaaa	Protospacer
 ******* ************.***.*    *

29. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttagaaattaaattaaataaagatatacattt	Protospacer
***    .**************** ** ***

30. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttagaaattaaattaaataaagatatacattt	Protospacer
***    .**************** ** ***

31. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttagaaattaaattaaataaagatatacattt	Protospacer
***    .**************** ** ***

32. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP013700 (Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttagaaattaaattaaataaagatatacattt	Protospacer
***    .**************** ** ***

33. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to AP014182 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S41-C49, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttaggagttacattagataaagatttagattt	Protospacer
***    .** ****.***************

34. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to AP014181 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S40-C70, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttaggagttacattagataaagatttagattt	Protospacer
***    .** ****.***************

35. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to AP014183 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C67-MedDCM-OCT-S42-C67, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ttaggagttacattagataaagatttagattt	Protospacer
***    .** ****.***************

36. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to MH319754 (Marine virus AG-345-L05 Ga0172272_11 genomic sequence) position: , mismatch: 8, identity: 0.758

ttattttctaaattaaataaagatttagattat	CRISPR spacer
atattttttaatttaaataaagatttattctta	Protospacer
 ******.*** ***************  .*

37. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to MN694459 (Marine virus AFVG_250M532, complete genome) position: , mismatch: 8, identity: 0.758

ttattttctaaattaaataaagatttagattat	CRISPR spacer
atattttcaaaattaaataaaaattcatcaaat	Protospacer
 ******* ************.***.*    **

38. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to MT782071 (Escherichia phage JN02, complete genome) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gctcttgctaaattacataaagatttagacgg	Protospacer
 . .** ******** *************. .

39. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to KY703222 (Escherichia phage phiC120, complete genome) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gctcttgctaaattacataaagatttagacgg	Protospacer
 . .** ******** *************. .

40. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to MN693034 (Marine virus AFVG_117M74, complete genome) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gaaattactaaattaaataaagagttagggat	Protospacer
  * ** **************** ****.

41. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP017256 (Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
aaatattctaaattaaataaagtttataaaaa	Protospacer
  ** ***************** **  .*  *

42. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tataaatataaattatataaagattttgattt	Protospacer
*     * ******* ********** ****

43. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tataaatataaattatataaagattttgattt	Protospacer
*     * ******* ********** ****

44. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tataaatataaattatataaagattttgattt	Protospacer
*     * ******* ********** ****

45. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP011146 (Bacillus cereus strain FORC_013 plasmid pFORC13, complete sequence) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
tataaatataaattatataaagattttgattt	Protospacer
*     * ******* ********** ****

46. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to MT774389 (CrAssphage cr116_1, complete genome) position: , mismatch: 9, identity: 0.719

ttattttctaaattaaataaagatttagatta	CRISPR spacer
actatacctaagttaattaaagatttagatga	Protospacer
 .  * .****.**** ************* *

47. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to MN693034 (Marine virus AFVG_117M74, complete genome) position: , mismatch: 9, identity: 0.727

ttattttctaaattaaataaagatttagattat	CRISPR spacer
gaaattactaaattaaataaagagttagggatt	Protospacer
  * ** **************** ****.   *

48. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NC_017472 (Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence) position: , mismatch: 10, identity: 0.688

ttattttctaaattaaataaagatttagatta	CRISPR spacer
gctacttctatatcaaataaagatttagagat	Protospacer
 .  .***** **.***************

49. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP031668 (Staphylococcus aureus strain 199 plasmid pPS00120.1A.1, complete sequence) position: , mismatch: 10, identity: 0.688

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ggtattactaaatcaaataaagatttaaaaat	Protospacer
    ** ******.*************.*

50. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_CP031671 (Staphylococcus aureus strain 64 plasmid pPS00119.1A.1, complete sequence) position: , mismatch: 10, identity: 0.688

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ggtattactaaatcaaataaagatttaaaaat	Protospacer
    ** ******.*************.*

51. spacer 6.5|2576655|32|NZ_AP018274|PILER-CR,CRT matches to NZ_LR130510 (Staphylococcus aureus strain BPH2760 isolate BPH2760 plasmid 2) position: , mismatch: 10, identity: 0.688

ttattttctaaattaaataaagatttagatta	CRISPR spacer
ggtattactaaatcaaataaagatttaaaaat	Protospacer
    ** ******.*************.*

52. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to MT782071 (Escherichia phage JN02, complete genome) position: , mismatch: 10, identity: 0.697

ttattttctaaattaaataaagatttagattat	CRISPR spacer
gctcttgctaaattacataaagatttagacggc	Protospacer
 . .** ******** *************. ..

53. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to KY703222 (Escherichia phage phiC120, complete genome) position: , mismatch: 10, identity: 0.697

ttattttctaaattaaataaagatttagattat	CRISPR spacer
gctcttgctaaattacataaagatttagacggc	Protospacer
 . .** ******** *************. ..

54. spacer 6.10|2576655|33|NZ_AP018274|CRISPRCasFinder matches to NC_017472 (Lactobacillus amylovorus GRL1118 plasmid p2, complete sequence) position: , mismatch: 11, identity: 0.667

ttattttctaaattaaataaagatttagattat	CRISPR spacer
gctacttctatatcaaataaagatttagagata	Protospacer
 .  .***** **.***************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1393340 : 1475674

Bacillus_phage(18.18%)

plate,tail,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096610996.1\|1393340_1394264_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_096610998.1\|1394311_1395112_-	hypothetical protein	NA	NA	NA	NA
WP_096611000.1\|1395195_1397433_-	hypothetical protein	NA	NA	NA	NA
WP_096611002.1\|1397477_1398878_-	HAMP domain-containing protein	NA	NA	NA	NA
WP_096611004.1\|1398964_1400059_-	DUF3365 domain-containing protein	NA	NA	NA	NA
WP_096611006.1\|1400242_1401550_-	hypothetical protein	NA	NA	NA	NA
WP_096611008.1\|1401659_1402709_-\|tail	phage tail protein	NA	NA	NA	NA
WP_096613364.1\|1402777_1404976_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_096611010.1\|1405042_1405444_-\|plate	baseplate protein	V5YTB2	Pseudomonas_phage	4.1e-11	48.8
WP_096613366.1\|1406619_1407024_+	hypothetical protein	NA	NA	NA	NA
WP_096611012.1\|1410106_1410787_-	hypothetical protein	NA	NA	NA	NA
WP_096611014.1\|1410978_1411188_-	Nif11-like leader peptide family natural product precursor	NA	NA	NA	NA
WP_096611016.1\|1411226_1413245_-	ATP-binding protein	K9MCS8	Sulfolobus_virus	1.4e-06	31.4
WP_096611018.1\|1413241_1413454_-	hypothetical protein	NA	NA	NA	NA
WP_096611020.1\|1413589_1414861_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_096611022.1\|1415525_1417232_+\|tail	phage tail sheath family protein	A0A127AW39	Bacillus_phage	2.7e-19	29.5
WP_096611024.1\|1417406_1417880_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096611026.1\|1417986_1418460_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096611028.1\|1418666_1419155_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096611030.1\|1419416_1419740_+	hypothetical protein	NA	NA	NA	NA
WP_096611032.1\|1419759_1420125_+	hypothetical protein	NA	NA	NA	NA
WP_096611034.1\|1420236_1420443_+	hypothetical protein	NA	NA	NA	NA
WP_096611036.1\|1420500_1421025_+\|tail	phage tail protein	NA	NA	NA	NA
WP_096611038.1\|1421028_1423704_+	hypothetical protein	NA	NA	NA	NA
WP_096611040.1\|1423746_1424253_+	hypothetical protein	NA	NA	NA	NA
WP_096611042.1\|1424335_1426297_+	type IV secretion protein Rhs	NA	NA	NA	NA
WP_096611044.1\|1426458_1426854_+	DUF4280 domain-containing protein	NA	NA	NA	NA
WP_096611046.1\|1426945_1429450_-	hypothetical protein	NA	NA	NA	NA
WP_096611048.1\|1429544_1431308_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096611050.1\|1431360_1432680_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_096611052.1\|1432771_1434208_+\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_096611054.1\|1434251_1434974_-	ABC transporter	G9BWD6	Planktothrix_phage	9.7e-88	75.6
WP_096611056.1\|1435021_1436197_-	ABC transporter	NA	NA	NA	NA
WP_096611059.1\|1436366_1437785_-	HlyD family secretion protein	NA	NA	NA	NA
WP_096611061.1\|1437971_1438835_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_096613368.1\|1440868_1441660_+	TVP38/TMEM64 family protein	NA	NA	NA	NA
WP_096610996.1\|1441844_1442768_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_096611063.1\|1442986_1443841_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_096611065.1\|1443948_1444320_+	DUF2834 domain-containing protein	NA	NA	NA	NA
WP_096611067.1\|1444356_1444776_+	GFA family protein	NA	NA	NA	NA
WP_096611069.1\|1444897_1446511_-	hypothetical protein	Q5GQG9	Synechococcus_phage	1.8e-09	39.1
WP_096611071.1\|1446708_1447707_-	ribose ABC transporter permease	NA	NA	NA	NA
WP_096611073.1\|1447703_1449257_-	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.4e-20	31.3
WP_096611075.1\|1449365_1450427_-	transcriptional regulator	NA	NA	NA	NA
WP_096611077.1\|1451985_1454733_-	carbonate dehydratase	A0A1J0FA34	Only_Syngen_Nebraska_virus	1.3e-68	28.9
WP_096611079.1\|1454861_1455989_+	ATP-binding protein	NA	NA	NA	NA
WP_096611081.1\|1456029_1458726_-	hypothetical protein	NA	NA	NA	NA
WP_096611083.1\|1458996_1460016_-	hypothetical protein	NA	NA	NA	NA
WP_096613370.1\|1460462_1461611_-	hypothetical protein	A0A2I7SAP6	Vibrio_phage	8.0e-28	27.9
WP_096611085.1\|1461643_1462654_-	MoxR family ATPase	H6WG28	Cyanophage	1.2e-83	46.7
WP_096611087.1\|1462870_1464355_-	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_096611089.1\|1464701_1465586_+	peptidase M15	NA	NA	NA	NA
WP_096611091.1\|1465710_1466715_+	glycerophosphodiester phosphodiesterase	NA	NA	NA	NA
WP_096611093.1\|1466872_1468261_-	hybrid sensor histidine kinase/response regulator	W8CYM9	Bacillus_phage	4.5e-17	37.2
WP_096611095.1\|1468316_1470680_-	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	2.7e-46	32.6
WP_096611097.1\|1471028_1471637_-	3-isopropylmalate dehydratase small subunit	NA	NA	NA	NA
WP_096611099.1\|1471778_1473194_-	3-isopropylmalate dehydratase large subunit	NA	NA	NA	NA
WP_096611101.1\|1473452_1473704_-	acetyltransferase	NA	NA	NA	NA
WP_096611103.1\|1474153_1475674_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

2528390 : 2614645

Alteromonas_phage(25.0%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096612609.1\|2528390_2529797_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	NA	NA	NA	NA
WP_096612611.1\|2529886_2530111_-	KTSC domain-containing protein	NA	NA	NA	NA
WP_096612613.1\|2530266_2535399_-	hypothetical protein	NA	NA	NA	NA
WP_096612615.1\|2535362_2536706_-	KAP family P-loop domain-containing protein	NA	NA	NA	NA
WP_096612617.1\|2537533_2537761_-	hypothetical protein	NA	NA	NA	NA
WP_096612619.1\|2538149_2538932_+	twin-arginine translocase subunit TatC	NA	NA	NA	NA
WP_096612621.1\|2539013_2539325_-	DUF3067 domain-containing protein	NA	NA	NA	NA
WP_096613533.1\|2539620_2540160_+	cytochrome b6-f complex iron-sulfur subunit	NA	NA	NA	NA
WP_096612623.1\|2540196_2541198_+	apocytochrome f	NA	NA	NA	NA
WP_096612625.1\|2541327_2541960_-	SH3 domain-containing protein	NA	NA	NA	NA
WP_096612627.1\|2542747_2543737_-	DUF3641 domain-containing protein	NA	NA	NA	NA
WP_096610164.1\|2544228_2545371_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_096612629.1\|2546588_2547557_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_096612631.1\|2548128_2548803_-	DNA-binding response regulator	A0A1J0GWE0	Alteromonas_phage	4.3e-05	27.4
WP_096612633.1\|2549341_2549629_-	nitrogenase	NA	NA	NA	NA
WP_096612635.1\|2549882_2551484_-	NAD(P)H-hydrate dehydratase	NA	NA	NA	NA
WP_096612637.1\|2551573_2553370_+	hypothetical protein	NA	NA	NA	NA
WP_096612639.1\|2553444_2553945_-	hypothetical protein	NA	NA	NA	NA
WP_096612641.1\|2554237_2554621_-	hypothetical protein	NA	NA	NA	NA
WP_096612643.1\|2555253_2555883_+	hypothetical protein	NA	NA	NA	NA
WP_096612645.1\|2555989_2556772_+	Zn-dependent hydrolase	NA	NA	NA	NA
WP_096612647.1\|2556885_2558364_+	alpha-amylase	NA	NA	NA	NA
WP_096612649.1\|2558768_2559224_-	hypothetical protein	NA	NA	NA	NA
WP_096612651.1\|2559220_2560180_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	1.4e-20	26.0
WP_096613535.1\|2560724_2562326_+	alkaline phosphatase	NA	NA	NA	NA
WP_096612653.1\|2562353_2563517_-	GNAT family N-acetyltransferase	G9BWD5	Planktothrix_phage	3.9e-14	35.1
WP_096612655.1\|2563720_2564128_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_096612657.1\|2564403_2565075_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_096612659.1\|2565228_2566590_-	hypothetical protein	NA	NA	NA	NA
WP_096612661.1\|2566993_2567479_+	hypothetical protein	NA	NA	NA	NA
WP_096612663.1\|2567671_2567983_-	DUF4282 domain-containing protein	NA	NA	NA	NA
WP_096612665.1\|2568340_2569786_-	hypothetical protein	NA	NA	NA	NA
WP_096613537.1\|2569995_2571342_+	alkaline phosphatase	NA	NA	NA	NA
WP_096612667.1\|2571412_2572324_-	hypothetical protein	NA	NA	NA	NA
WP_096612669.1\|2572701_2573874_+	phosphonopyruvate decarboxylase	NA	NA	NA	NA
WP_096612671.1\|2573947_2575027_+	2-aminoethylphosphonate--pyruvate transaminase	NA	NA	NA	NA
WP_096612673.1\|2575269_2575800_-	hypothetical protein	NA	NA	NA	NA
WP_096612675.1\|2576801_2579267_-	S-layer family protein	NA	NA	NA	NA
WP_096612677.1\|2579415_2581053_-	hypothetical protein	NA	NA	NA	NA
WP_096612680.1\|2581166_2581847_-	hypothetical protein	NA	NA	NA	NA
WP_096612682.1\|2581905_2584284_-	hypothetical protein	NA	NA	NA	NA
WP_096612684.1\|2584437_2586918_-	S-layer family protein	NA	NA	NA	NA
WP_096613173.1\|2588191_2589427_-	hypothetical protein	NA	NA	NA	NA
WP_096609659.1\|2589498_2589750_-	hypothetical protein	NA	NA	NA	NA
WP_096612686.1\|2589829_2591401_-	filamentous hemagglutinin N-terminal domain-containing protein	NA	NA	NA	NA
WP_096613539.1\|2591512_2593324_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	4.6e-94	39.8
WP_096612688.1\|2593985_2596484_-	S-layer family protein	NA	NA	NA	NA
WP_096612690.1\|2596549_2599126_-	S-layer family protein	NA	NA	NA	NA
WP_096612692.1\|2599232_2599436_-	hypothetical protein	NA	NA	NA	NA
WP_096612694.1\|2599512_2601999_-	S-layer family protein	NA	NA	NA	NA
WP_096613183.1\|2603578_2604649_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096613183.1\|2606411_2607482_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096612696.1\|2607670_2609338_-	hypothetical protein	NA	NA	NA	NA
WP_096612698.1\|2609398_2611198_-	ShlB/FhaC/HecB family hemolysin secretion/activation protein	NA	NA	NA	NA
WP_096610164.1\|2611442_2612585_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_096612700.1\|2613514_2614645_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_AP018277

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

44475 : 108356

Virus_Rctr85(14.29%)

protease,transposase,integrase

attL 65882:65941|attR 91803:92806

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096613902.1\|44475_45432_-\|integrase	integrase	A0A1P8DJ76	Virus_Rctr85	6.4e-55	42.6
WP_096613904.1\|45613_46000_-\|protease	aspartyl protease	NA	NA	NA	NA
WP_096613906.1\|45990_46314_-	hypothetical protein	NA	NA	NA	NA
WP_096613999.1\|46348_46885_-	hypothetical protein	NA	NA	NA	NA
WP_096613908.1\|47074_47959_-	DUF4351 domain-containing protein	NA	NA	NA	NA
WP_096614001.1\|48468_50580_-	hypothetical protein	NA	NA	NA	NA
WP_096613910.1\|50783_51485_-	hypothetical protein	NA	NA	NA	NA
WP_096613912.1\|51713_52151_-	hypothetical protein	NA	NA	NA	NA
WP_096613914.1\|52156_52450_-	hypothetical protein	NA	NA	NA	NA
WP_096613916.1\|52667_52937_-	hypothetical protein	NA	NA	NA	NA
WP_096613918.1\|52936_53185_-	hypothetical protein	NA	NA	NA	NA
WP_096613920.1\|53554_53989_-	hypothetical protein	NA	NA	NA	NA
WP_096613922.1\|54015_54963_-	hypothetical protein	NA	NA	NA	NA
WP_096613924.1\|55291_55462_+	ParG	NA	NA	NA	NA
WP_096613926.1\|56739_60585_+	hypothetical protein	NA	NA	NA	NA
WP_096614003.1\|61226_61802_+	hypothetical protein	NA	NA	NA	NA
WP_096613928.1\|61798_62446_+	hypothetical protein	NA	NA	NA	NA
WP_096613930.1\|63559_63961_-	hypothetical protein	NA	NA	NA	NA
WP_096613932.1\|64171_64567_-	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_096613934.1\|65301_65907_+	hypothetical protein	NA	NA	NA	NA
65882:65941	attL	NA	NA	NA	NA
WP_096613936.1\|67497_68355_+	hypothetical protein	NA	NA	NA	NA
WP_096613938.1\|68795_69791_+	hypothetical protein	NA	NA	NA	NA
WP_096613940.1\|70080_70395_+	hypothetical protein	NA	NA	NA	NA
WP_096613942.1\|70851_71805_-	hypothetical protein	NA	NA	NA	NA
WP_096613944.1\|71750_72353_-	ParA family protein	A0A2P1A2G0	Mycobacterium_phage	6.8e-10	30.5
WP_096613946.1\|72902_77114_-	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	1.1e-24	31.3
WP_096613948.1\|77157_77418_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_096613950.1\|77748_77934_+	hypothetical protein	NA	NA	NA	NA
WP_096613952.1\|78906_81531_-	S-layer family protein	NA	NA	NA	NA
WP_096614005.1\|82260_82665_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_041741238.1\|83610_83835_+	hypothetical protein	NA	NA	NA	NA
WP_096613954.1\|83831_84251_+	PIN domain-containing protein	NA	NA	NA	NA
WP_096613956.1\|84655_85258_+	hypothetical protein	NA	NA	NA	NA
WP_096613958.1\|85271_85511_+	hypothetical protein	NA	NA	NA	NA
WP_096613960.1\|85507_85774_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A2P1N333	Gordonia_phage	2.1e-16	50.6
WP_096613962.1\|86444_87452_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_096613964.1\|87506_87935_+	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_096613966.1\|87877_88189_-	hypothetical protein	NA	NA	NA	NA
WP_096613968.1\|88467_88731_+	hypothetical protein	NA	NA	NA	NA
WP_096613970.1\|89136_90210_-	sensor histidine kinase	NA	NA	NA	NA
WP_096613972.1\|90216_91383_-	hypothetical protein	NA	NA	NA	NA
WP_096613974.1\|91796_92748_-\|transposase	IS630 family transposase	A0A2H4UV16	Bodo_saltans_virus	8.2e-18	27.5
WP_096613976.1\|93955_94645_+	hypothetical protein	NA	NA	NA	NA
91803:92806	attR	NA	NA	NA	NA
WP_096613979.1\|95112_95952_-	VCBS repeat-containing protein	NA	NA	NA	NA
WP_096613981.1\|98549_98858_-	hypothetical protein	NA	NA	NA	NA
WP_096613983.1\|99203_99395_+	hypothetical protein	NA	NA	NA	NA
WP_096613183.1\|99570_100641_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_096613985.1\|100940_102266_-	hybrid sensor histidine kinase/response regulator	W8CYM9	Bacillus_phage	3.1e-15	36.4
WP_096613987.1\|102262_104506_-	HAMP domain-containing protein	Q8QKV7	Ectocarpus_siliculosus_virus	1.5e-46	32.8
WP_096613989.1\|104502_105459_-	phosphate/phosphite/phosphonate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_096613183.1\|107285_108356_-\|transposase	IS701 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_AP018276

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 17966

Bacillus_phage(50.0%)

integrase

attL 10462:10474|attR 23267:23279

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096613777.1\|983_5468_-	hypothetical protein	NA	NA	NA	NA
WP_096613779.1\|5531_6554_-	hypothetical protein	NA	NA	NA	NA
WP_096613781.1\|6602_7508_-	hypothetical protein	NA	NA	NA	NA
WP_096613783.1\|7583_8213_-	hypothetical protein	NA	NA	NA	NA
WP_096613785.1\|8224_9073_-	hypothetical protein	NA	NA	NA	NA
WP_096613787.1\|9076_10066_-	hypothetical protein	NA	NA	NA	NA
WP_096613789.1\|10151_12479_-	hypothetical protein	NA	NA	NA	NA
10462:10474	attL	NA	NA	NA	NA
WP_096613791.1\|13145_14078_-\|integrase	integrase	A0A0E3M2X0	Bacillus_phage	1.3e-15	26.5
WP_096613793.1\|14861_15056_+	hypothetical protein	NA	NA	NA	NA
WP_096613795.1\|16052_17966_+	DUF3991 domain-containing protein	M1NXP9	Cellulophaga_phage	6.0e-12	27.5
23267:23279	attR	NA	NA	NA	NA

DBSCAN-SWA_2

23638 : 29770

Leptospira_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_096613805.1\|23638_24661_-	chromosome partitioning protein ParB	S5VTK0	Leptospira_phage	1.1e-09	33.6
WP_096613807.1\|24657_25413_-	ParA family protein	A0A240F4U1	Ochrobactrum_phage	1.1e-17	29.7
WP_096613809.1\|25616_25808_-	hypothetical protein	NA	NA	NA	NA
WP_096613811.1\|25894_26341_-	PIN domain-containing protein	NA	NA	NA	NA
WP_096613813.1\|26337_26577_-	hypothetical protein	NA	NA	NA	NA
WP_096613815.1\|26830_29770_-	calcium-translocating P-type ATPase, PMCA-type	A0A1J0FA34	Only_Syngen_Nebraska_virus	3.9e-103	31.9

DBSCAN-SWA_3

50431 : 51397

Clostridioides_phage(100.0%)

integrase

attL 39686:39697|attR 52605:52616

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
39686:39697	attL	NA	NA	NA	NA
WP_096613838.1\|50431_51397_+\|integrase	integrase	A0A2R2ZHE2	Clostridioides_phage	1.2e-13	24.2
WP_096613838.1\|50431_51397_+\|integrase	integrase	A0A2R2ZHE2	Clostridioides_phage	1.2e-13	24.2
52605:52616	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage