CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP024123	Solibacillus sp. R5-41 chromosome, complete genome	1 crisprs	DEDDh,cas3,DinG,csa3,WYL,RT	0	5	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP024123_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP024123_1

1627048-1630325

Orphan

Consensus_repeat	Method
GCAGTAGNGTCAGCATCAGCAGTAG	CRT

25 spacers

The CRISPR arrays of NZ_CP024123_1

>merge|NZ_CP024123|1|1627048-1630325|CRT
GAAGTAGCGTCAGAGTCAGCAGTAGCATCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCATCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCGTCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCGGAATCAGCAGTAGCGTCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCGGCATCAGCAGTAGAGTCAGCATCGGCAGTAGAGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCGGCATCAGCAGTAGAATCAGCATCAGCGGTAGAGTCAGCATCGGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCGGCATCGGCAGTAGAGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCAGCATCGGCAGTAGAGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGAGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCGGCATCAGCAGTAGAATCAGCATCAGCGGTAGAGTCAGCATCAGCAGTAGAGTCGGCATCGGCAGTAGAGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCAGCATCAGCAGTAGAGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCGGCGTCAGCAGTAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCAGCATCGGCAGTAGAGTCAGCATCAGCAGTAGAGTCAGCATCGGCAGTAGCATCAGCATCAGCAGTAGAGTCGGCATCAGCAGTAGAGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGAGTTGGCATCGGCAGTAGAGTCAGCATCAGCAGTAGCGGTAGCATCAGCGTCTACGTTAGAGTCAACGTCAGCAGTAGAGTCAGCATCAGCAGTAGAATCGGCGTCAGCAGTAGCGTCAGCATCGGCAGTAGAATTGGAATCAGCAGTAGCGTCAGCATCAGAAGTAGAATCTGCATCGGCAGTAGAGTCAGCATCAGCGGTAGAGTCGGCGTCAGCAGTAGAATCAGCGTCAGCAGTAGAGTCAGCATCGGCAGTAGAATTGGAATCAGCAGTAGAGTCAGCATCGGCAGTAGAATTGGAATCAGCAGTAGAGTCAGCATCGGCAGTAGAATTGGAATCAGCAGTAGCGTCAGCATCAGCAGTAGCTTTAGCATCAGCATCAG

>NZ_CP024123|1|1|1627048-1630325|CRT
GAAGTAGCGTCAGAGTCAGCAGTAG	CATCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCATCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCGTCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCGGAATCAGCAGTAGCGTCGGAATCAGCAGTAGAAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCA
GCAGTAGCGTCAGAGTCAGCAGTAG	CGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCAGAGTCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCGGCATCAGCAGTAGCGTCAGCATCA
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCGGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATC
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCG
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCG
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCATCG
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCAGCATCAGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCA
GCAGTAGCGTCAGCATCAGCAGTAG	AGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCAGCATCAGCAGTAGAGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCGGCATCA
GCAGTAGAGTCAGCATCGGCAGTAG	AGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCGGCATCAGCAGTAGAATCAGCATCAGCGGTAGAGTCAGCATCG
GCAGTAGCGTCAGCATCGGCAGTAG	CGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCGGCATCGGCAGTAGAGTCAGCATCAGCAGTAGCGTCAGCATCA
GCAGTAGAGTCAGCATCGGCAGTAG	AGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCA
GCAGTAGAGTCAGCATCGGCAGTAG	CGTCAGCATCAGCAGTAGAGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCA
GCAGTAGAGTCAGCATCAGCAGTAG	AGTCGGCGTCAGCAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCA
GCAGTAGAGTCGGCATCAGCAGTAG	AATCAGCATCAGCGGTAGAGTCAGCATCAGCAGTAGAGTCGGCATCGGCAGTAGAGTCAGCATCA
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGAGTCAGCATCAGCAGTAGAGTCAGCATCA
GCAGTAGCGTCAGCATCAGCAGTAG	CGTCAGCATCGGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCAGCAGTAGCGTCAGCATCA
GCAGTAGCGTCGGCGTCAGCAGTAG	CAGTAGCAGTAGCATCAGCGTCTACGTTAGAATCAACGTCAGCAGTAGAGTCAGCATCG
GCAGTAGAGTCAGCATCAGCAGTAG	AGTCAGCATCGGCAGTAGCATCAGCATCAGCAGTAGAGTCGGCATCA
GCAGTAGAGTCAGCATCAGCAGTAG	AGTCGGCGTCAGCAGTAGAGTTGGCATCG
GCAGTAGAGTCAGCATCAGCAGTAG	CGGTAGCATCAGCGTCTACGTTAGAGTCAACGTCA
GCAGTAGAGTCAGCATCAGCAGTAG	AATCGGCGTCAGCAGTAGCGTCAGCATCG
GCAGTAGAATTGGAATCAGCAGTAG	CGTCAGCATCAGAAGTAGAATCTGCATCG
GCAGTAGAGTCAGCATCAGCGGTAG	AGTCGGCGTCAGCAGTAGAATCAGCGTCA
GCAGTAGAGTCAGCATCGGCAGTAG	AATTGGAATCAGCAGTAGAGTCAGCATCGGCAGTAGAATTGGAATCA
GCAGTAGAGTCAGCATCGGCAGTAG	AATTGGAATCAGCAGTAGCGTCAGCATCA
GCAGTAGCTTTAGCATCAGCATCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP024123.1\|WP_099423351.1\|1638102_1638720_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423345.1\|1632011_1632905_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226231
NZ_CP024123.1\|WP_099423347.1\|1634219_1634477_+\|translation-initiation-factor-2	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423343.1\|1625778_1626066_-\|transposase	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423354.1\|1640515_1640998_+\|YjdJ-family-protein	unknown	unknown	gnl\|CDD\|316659
NZ_CP024123.1\|WP_099423340.1\|1622134_1622743_+\|potassium-transporting-ATPase-subunit-KdpC	unknown	unknown	gnl\|CDD\|172497
NZ_CP024123.1\|WP_099423337.1\|1614402_1615104_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP024123.1\|WP_099423344.1\|1626333_1626675_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423353.1\|1639603_1640272_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
NZ_CP024123.1\|WP_099423350.1\|1635940_1636720_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NZ_CP024123.1\|WP_099423338.1\|1615096_1617793_-\|sensor-histidine-kinase-KdpD	unknown	unknown	gnl\|CDD\|225115
NZ_CP024123.1\|WP_099423339.1\|1618222_1620037_+\|potassium-transporting-ATPase-subunit-KdpA	unknown	unknown	gnl\|CDD\|377138
NZ_CP024123.1\|WP_099423341.1\|1623201_1624491_-\|DUF2252-family-protein	unknown	unknown	gnl\|CDD\|313268
NZ_CP024123.1\|WP_157764762.1\|1625051_1625222_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423348.1\|1634576_1634735_-\|uroporphyrinogen-III-decarboxylase	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423342.1\|1625531_1625765_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176191
NZ_CP024123.1\|WP_099423346.1\|1633721_1633946_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP024123.1\|WP_099423349.1\|1634856_1635396_-\|DUF1572-family-protein	unknown	unknown	gnl\|CDD\|311521
NZ_CP024123.1\|WP_099425781.1\|1620052_1622116_+\|potassium-transporting-ATPase-subunit-KdpB	unknown	unknown	gnl\|CDD\|234905
NZ_CP024123.1\|WP_157764769.1\|1639047_1639158_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP024123.1\|WP_099423345.1\|1632011_1632905_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|226231	COG3708, COG3708, Uncharacterized protein conserved in bacteria [Function unknown].	4.76489e-33
NZ_CP024123.1\|WP_099423350.1\|1635940_1636720_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	0.00405437
NZ_CP024123.1\|WP_099423340.1\|1622134_1622743_+\|potassium-transporting-ATPase-subunit-KdpC	gnl\|CDD\|172497	PRK13996, PRK13996, potassium-transporting ATPase subunit C; Provisional.	1.09805e-102
NZ_CP024123.1\|WP_099423337.1\|1614402_1615104_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.43464e-79
NZ_CP024123.1\|WP_099423353.1\|1639603_1640272_+\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	5.58862e-17
NZ_CP024123.1\|WP_099423338.1\|1615096_1617793_-\|sensor-histidine-kinase-KdpD	gnl\|CDD\|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	0
NZ_CP024123.1\|WP_099423339.1\|1618222_1620037_+\|potassium-transporting-ATPase-subunit-KdpA	gnl\|CDD\|377138	pfam03814, KdpA, Potassium-transporting ATPase A subunit.	0
NZ_CP024123.1\|WP_099423341.1\|1623201_1624491_-\|DUF2252-family-protein	gnl\|CDD\|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	6.04415e-90
NZ_CP024123.1\|WP_099423354.1\|1640515_1640998_+\|YjdJ-family-protein	gnl\|CDD\|316659	pfam14154, DUF4306, Domain of unknown function (DUF4306). This family includes the B. subtilis YjdJ protein, which is functionally uncharacterized. This is not a homolog of E. coli YjdJ, which belongs to pfam00583. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 152 amino acids in length.	1.85266e-28
NZ_CP024123.1\|WP_099423342.1\|1625531_1625765_+\|hypothetical-protein	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0.000309497
NZ_CP024123.1\|WP_099423349.1\|1634856_1635396_-\|DUF1572-family-protein	gnl\|CDD\|311521	pfam07609, DUF1572, Protein of unknown function (DUF1572). These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.	4.52856e-88
NZ_CP024123.1\|WP_099425781.1\|1620052_1622116_+\|potassium-transporting-ATPase-subunit-KdpB	gnl\|CDD\|234905	PRK01122, PRK01122, potassium-transporting ATPase subunit KdpB.	0

>NZ_CP024123.1|WP_099423344.1|1626333_1626675_-|hypothetical-protein
MSNTTVSRCTIPREEDSDSIYVKVKNKNQKISRQITINAYSKNSPTKELLPVYVDDQPTHIDTLEPETERVYRIDVSNVKGQVIFEITQKNGSSGIKVSKNSKNPSSVELHIK
>NZ_CP024123.1|WP_099423343.1|1625778_1626066_-|transposase
MKLLLVISSIVVPIVMLYLQQKSNQFKMLFNIVATISIIIFGSLASMSIYQVIIDDAVFMTTIHGLFLNPVFLVTGAYLGTFVIYRLMMLTLDER
>NZ_CP024123.1|WP_099423342.1|1625531_1625765_+|hypothetical-protein
MPNGVDDALAIQPGTSLTSMKIVKDGGKVVTISGDQFETERQITTEQITQLPEIQRELATLTTKVAEGRIRMSFRMK
>NZ_CP024123.1|WP_157764762.1|1625051_1625222_+|hypothetical-protein
MDYEVAFAYGSEGLITDSVNGVDEITVEDGAYFFFDSDEEMIYSAPLVSVVYIKRV
>NZ_CP024123.1|WP_099423341.1|1623201_1624491_-|DUF2252-family-protein
MGSMLLEQVKHTRKFLRHDQLKTIFEEFDVQCMSLSEEQRLEKYRTMLDSPFRFFRGSAYLFYYDMTKTPSIFHTPDAKPTWIQGDMHMDNFGAFQNETGDIVYDVNDFDEGYVGSYLYDVIRMSVSIALYIEEQGLHNGAQEMAIHHFLRSYISQLTRFQRKQDDPLTLTFTKNNTKGPIKKVLKKLEKRQHSHLLQDITHINEDGNRVFLWNDEVQPVSNEEIAAITKTLPNYSIKDIAIKYGSGTASIGLKRYYILVDGATDALGVGDLVLEMKEVRTAIPAYFLPYHKTFWTHYEHQGARVVGTQKAMHHLEDPHLAYVTMDGQEYYIRERSPYKKKVKPKNYTDLDDYFVTTSIMGQIAAKIHARADIDYSDVFTYHSEDAILIAIGKHKDYFIESVTLQAMHYKEIVYSDYELFKEWVNDTFS
>NZ_CP024123.1|WP_099423340.1|1622134_1622743_+|potassium-transporting-ATPase-subunit-KdpC
MKLLKGTLSRSIVFFFIFTFICGVVYPVTMTGMAQIVFPEKANGSIIEVEGKNYGSALLGQQFTGDTHMWGRIMQIDTATYKDAEGNPLMYAFPANLSPASEEYGELIAERVTKIQAAHPEKATMRIPVDLVTSSGSGLDPSISVAAANYQIERLAKNNNLSIEEVKFIIEQCSESRFLGVFGEVTVNVLKVNLMLDGILEY
>NZ_CP024123.1|WP_099425781.1|1620052_1622116_+|potassium-transporting-ATPase-subunit-KdpB
MTTSKSALTDKTMLMRAIKDSFVKLSPKYQAENPVMLLVYISAVLTSALFAISLFGIQDASSGYTFAIAVILWFTVLFANFAEAIAEGKGKAQADSLRAAKKDVPANKIRSLDNLEDVTVVSSATLQKGDFVIVKAGEQIPADGEVIEGAASVDESAITGESAPVIRESGGDRSAVTGGTTVISDALIIRVTSIPGESFLDKMIAMVEGASRKKTPNELALQILLVALSIIFILVTVSLYAFAGFSANLANKENPVSVTTLVALLVCLAPTTIGALLSAIGIAGMSRLNQANVLAMSGRAIEAAGDVDILMLDKTGTITIGNRQATEFIPVDGVTAKELADSAQLSSLADETPEGRSIVVLAKKEFDIRGRSMKGSPLDFIPFTAKTRMSGVNFEGNEIRKGAADVMRAYVEQNGGTYSKHCEKTVQKIAKKGGTPLVVTKNYRVQGVIYLKDIIKQGVKEKFADLRKMGIKTIMITGDNPLTAAAIAAEAGVDDFLAEATPEAKLQKIREFQRKGHLVAMTGDGTNDAPALAQADVAVAMNTGTQAAKEAGNMVDLDSSPTKLIEIVRIGKQLLMTRGSLTTFSIANDLAKYFAIIPALFIGLYPELSKLNIMQLHSPESAILSAIIYNALIIIALIPLALSGVKYREVPAGKLLSRNLLIYGLGGIITPFIFIKLIDIALVVLGI
>NZ_CP024123.1|WP_099423339.1|1618222_1620037_+|potassium-transporting-ATPase-subunit-KdpA
MNLILQYGLYLGFLVLLAIPLGHYIGKVMNGEKVILSNLLKPLEQMIYKVMKIEASEQMSWKKYATSVLLFSGIGFIFLFVLQLVQGALTGNPQGIANMSWHLSFNNAISFITNTNWQSYTGEAQITYLVQALGLTVQNFVSAATGIAVLFALIRAFINVKSNGLGSFWIDVTRVNLYVLIPISFVITLCLLSQGVVQNLKPAETVQLLEPIAIAEDGTIIDSAQIDVESKEVFVNGELVANAQIVTEQFVPMGPAASQIAIKQLGTNGGGFFGVNSAHPFENPTAFSNLIEMLSILLIPVALCFTFGRNIKDKKQGYAIFSAMFIILMLAMAALAVNEQLGTPQLAQDGMVDLSTEAQAGGNMEGKESRFGIAASTTWTAFTTAASNGSVNSMHDSLTPLGGMVPMLLMQLGEVIFGGVGSGLYGMLSFVILTVFIAGLMVGRTPEYLGKKIEPYEMKWAVLCCLATPIAILVSGGIAALVPSVTNSLNEVGPHGFSELLYAFTSAGANNGSAFAGLAANTPFINLSLGLAMLFARFVPILCTLAIAGSLIQKKKMATTAGTLSTSNGLFIFLLIFVVILVGALSFFPALALGPIAEFMIMVN
>NZ_CP024123.1|WP_099423338.1|1615096_1617793_-|sensor-histidine-kinase-KdpD
MSFEREDPDAILKKIQMIKKEKHQGHLKIFFGYAAGVGKTYAMLKAAHLAKEHGIEVVAGYIEPHARPETMALLQGIEQLPYLQVQHKNMLLHELDLDAAIVRNPQIILVDELAHTNIEQARHLKRYQDIQELLKAGIDVYTTINVQHIESLNDLVASITGVVVRERIPDYVFDEANLVTLVDIEPADLLERLNEGKIYNHDQAEKAMNHFFTLENLVALREIALRRTADRVNRVAEKSNISSKSSLNAGEHILVCLSSSPSNAKIIRTAARMASAFKGNFTALFVETASFGEWSDINKARLQKNMRLAEQLGANIEKVYGEDVAFQISEFARYIRVTKIVIGRSNTKRNFLSIKKSFTEQLTNLSPNLDIYVIPDQQAEPYKKKTTLKKSSWCSGMDLLKVALTLAITTAIGFVFQTFNFSNTDIINMYILGVLVTAIITANLFCSILMATLSVIAFNFFFTYPIFSLEANDPSHHITFLIMFITAFIIGTLASKLKIQAQHSAETAYRTKVLLETNQLLQQETQQEGILATTAKQLVKLLNHSVVFYPIHEQNLAQPIVFFEQDETDSTEFTTDNEQAVAAWVFKNNKHAGATTNTLGSAKCLYLAIRTNLRVYGVIGIALKENKTLDTLENNLVLSMLGECALALEKEHFIRKREEAATQVKNEQLRANLLRAISHDLRSPLTTISGNAHILLSNEFSIDEDKKMRLFEDIYNDAQWLINLVENLLSITSIENGTMNIQMDAELIDEVINEALLHVNRRSRDHIIKVDYADGILIAKLDPRLIVQVLINLIDNAIKYTPVGSEITISTKKENDWIVVDITDNGDGIPDTAKEKIFEMFYTVHKSVSDSRRGIGIGLALCKSIISVHGGSLTVHDHYPKGTIFRFTLQAKEVKIYE
>NZ_CP024123.1|WP_099423337.1|1614402_1615104_-|response-regulator-transcription-factor
MSKPFVLVVEDDEAIKNLISITLETQEYKFHTASRGSQAILETISHNPDIVILDLGLPDMDGIEIIKKIRSWSTMPIIVVSARSMDQDKIEALDAGADDYLTKPFSIEELLARLRVAIRRIHYHKSDSPQQNLHFTNGDLKIDYVAGCAYLKDMELHLTPIEYKLLVLLSKNAGKVLTHNYITKEIWGSTWENDVSSLRVFMATLRKKIELNSTQPKYIQTHIGVGYRMLKNE
>NZ_CP024123.1|WP_099423345.1|1632011_1632905_-|AraC-family-transcriptional-regulator
MDTITTLQDILDYVDKHIKDDISPDILAARAGYSTWHFSKVFQWGIGYSLMTYVRNRRLAFAAHELSSGRKILDISMEYGFETHSGFSKAFRRHFGCSPGTYRLHTHCDRPFPPSLPLTNKYLIGGIIMEPKFVTRSAINIAGFAIKTTSTDGENSKAIPAFWDDYMSSGKMENLHAENFIKNHDEYGVCFQVDMETGEFEYVIGVEPIDGAEIPNDYHVCEVPPASYAVFSTPPCAAANFAQNIQGTWNYIFNEWFPKSGYEYAPNCVDFELYDDRCMEDEGKICDIYIPVIKKQN
>NZ_CP024123.1|WP_099423346.1|1633721_1633946_-|hypothetical-protein
MQWLQKVGHLTGQPVGISLTNGQGTSGILCGTSNGKLLVIEYLYQAQFALKQYDFYLIQDIHGFPHCQNQHPLY
>NZ_CP024123.1|WP_099423347.1|1634219_1634477_+|translation-initiation-factor-2
MEEMTMDNNESQEIFIAQLSYIGAAISTLGDGIQAIAAGLTLESLKNANNQSSENSTDQSQKTESMQKQIDFLISELKQIKKILK
>NZ_CP024123.1|WP_099423348.1|1634576_1634735_-|uroporphyrinogen-III-decarboxylase
MENTKIAKLGPEQIKELKSLEEKLDVTLIAYAPSSSGHHIGQENNTTTTNPA
>NZ_CP024123.1|WP_099423349.1|1634856_1635396_-|DUF1572-family-protein
MRIETEYLRVIKERFQSVKSLGDNAIEQLVEDDIHWALNEESNSVAVIVSHLSGNMISRWTDFLNSDGEKPYRNREQEFVDNISSKAELIAILEIGWNTLFEALNNLSEEDLLKVVFIRGQSHSVIEAIERQLAHYAYHIGQIVYIGKQIKSENWESLSIPIGQSESYLQQMLKKHQSE
>NZ_CP024123.1|WP_099423350.1|1635940_1636720_+|GNAT-family-N-acetyltransferase
MDKNELISRFHKELRYESLIQGYIREETEHVVRHISMFDEKGFIIASNVNVGNAREIIRNELNYFSNCKQDFEWKVYSYDKPDSLKDILDQEGFKIDNPEALMVMKLDDRHPFLSNSPFLSVKEITDEQGIQDIVVLEDTIWNESHAELGERLWRDKQNNPDSLYLYGIYENGQLVSAAWMYLETNSSFASLWGGSTLPLFRGKGYYTKLLTVRAQKAYEKGHPFLTVDASPMSRPILEKHCFCCLAYSYGCQSPTTQK
>NZ_CP024123.1|WP_099423351.1|1638102_1638720_+|hypothetical-protein
MTQTSRTNPRSAVHGTASGVFFMAFFGTLWAYTGIMGLQGWGVPLLLVATVTIGIALFIGGVSLLRASRELTEQVSKTDFRRGKRIRFWFNIIFAAEGLAIAITIAVCNATRHTELIPVLIAIIVGVHFIPLAPLFQVRLYYFTGALLCLLAIITLLFVPAKVTLGEHQINAFMSVVGFGSALILWATGLAIWLMGRRLLGIVPE
>NZ_CP024123.1|WP_157764769.1|1639047_1639158_+|hypothetical-protein
MGLREYKRTQNLLWGTICLCISLYILFVAVDGIMFN
>NZ_CP024123.1|WP_099423353.1|1639603_1640272_+|DNA-alkylation-repair-protein
MDEKKDTEIKRSSKAENILPQINSKTKLGDLRKIAKDIKKDHELAMELWSTEEFLPRLLAILIMEKKLLSHDVLNKLDKDMQTHTFDERNNLMDWLMANQLTKDKKKIALMESWENSPFALQRRAFWYYQGRLRWTGQTPPDNTADLLSALEANITQEEPEVQWAMNFTAGWIGVYDEKNRARCIKLGEKTGLYKDEIVAKGCTPSYLPEFITIEVNKRHNN
>NZ_CP024123.1|WP_099423354.1|1640515_1640998_+|YjdJ-family-protein
MFKYVLQLIVGIFTLVVSTLIAWYEGSAIIENSWEWKYSTPFTKLFNIEITNGRDISQLDYFVYAAKFQPLFPAIMMVSVFYILSVVGYYFVKYKPKWAIGFLGLIGCIMILLSGFIFNSTTIGGRIFFWITLVSGLISIAFTVFVCLRNFKHMVSVNTN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP024123_1	1.21\|1630038\|29\|NZ_CP024123\|CRT	1630038-1630066	29	NZ_CP020372	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence	208384-208412	5	0.828
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	MN693260	Marine virus AFVG_25M320, complete genome	14558-14586	6	0.793
NZ_CP024123_1	1.21\|1630038\|29\|NZ_CP024123\|CRT	1630038-1630066	29	NZ_CP016891	Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence	196968-196996	6	0.793
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013827	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15C-MedDCM-OCT-S33-C119, * SEQUENCING IN PROGRESS *	11960-11988	6	0.793
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013811	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S36-C173, * SEQUENCING IN PROGRESS *	8753-8781	6	0.793
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	JX519263	Uncultured Mediterranean phage MEDS1 group fosmid MedDCM-OCT-S13-C2, complete sequence	13152-13180	6	0.793
NZ_CP024123_1	1.23\|1630146\|29\|NZ_CP024123\|CRT	1630146-1630174	29	NZ_CP054621	Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence	722045-722073	6	0.793
NZ_CP024123_1	1.23\|1630146\|29\|NZ_CP024123\|CRT	1630146-1630174	29	MF370964	Pseudoalteromonas phage SL20, complete genome	113543-113571	6	0.793
NZ_CP024123_1	1.23\|1630146\|29\|NZ_CP024123\|CRT	1630146-1630174	29	AP013944	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S41-C114, * SEQUENCING IN PROGRESS *	22250-22278	6	0.793
NZ_CP024123_1	1.23\|1630146\|29\|NZ_CP024123\|CRT	1630146-1630174	29	AP013933	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5-MedDCM-OCT-S40-C161, * SEQUENCING IN PROGRESS *	2352-2380	6	0.793
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP045721	Pantoea eucalypti strain LMG 24197 plasmid unnamed1, complete sequence	343888-343916	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP034149	Pantoea agglomerans strain L15 plasmid pPagL15_1, complete sequence	132652-132680	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP022517	Pantoea vagans strain FBS135 plasmid pPant1, complete sequence	63236-63264	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	MN176217	Escherichia phage vB_Eco4M-7, complete genome	56604-56632	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	MH051335	Escherichia phage vB_EcoM-Ro157lw, complete genome	50459-50487	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NC_048194	Escherichia phage vB_EcoM_WFH, complete genome	50406-50434	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NC_048195	Escherichia phage vB_EcoM_WFC, complete genome	50354-50382	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NC_022916	Burkholderia phage JG068, complete genome	35225-35253	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	MT446408	UNVERIFIED: Escherichia virus TH35, complete genome	5440-5468	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NC_048073	Escherichia phage FEC19, complete genome	19992-20020	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP014457	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S45-C173, * SEQUENCING IN PROGRESS *, 2 ordered pieces	9096-9124	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013822	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15B-MedDCM-OCT-S24-C103, * SEQUENCING IN PROGRESS *	5253-5281	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP014453	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S36-C132, * SEQUENCING IN PROGRESS *, 5 ordered pieces	13795-13823	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013824	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15B-MedDCM-OCT-S29-C131, * SEQUENCING IN PROGRESS *	4697-4725	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013823	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15B-MedDCM-OCT-S26-C119, * SEQUENCING IN PROGRESS *	12082-12110	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013826	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15C-MedDCM-OCT-S23-C82, * SEQUENCING IN PROGRESS *	11960-11988	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	MN693064	Marine virus AFVG_25M35, complete genome	22294-22322	7	0.759
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	AP013807	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S28-C82, * SEQUENCING IN PROGRESS *	10522-10550	7	0.759
NZ_CP024123_1	1.23\|1630146\|29\|NZ_CP024123\|CRT	1630146-1630174	29	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	333224-333252	7	0.759
NZ_CP024123_1	1.25\|1630272\|29\|NZ_CP024123\|CRT	1630272-1630300	29	NZ_CP031226	Pseudomonas amygdali pv. lachrymans str. M301315 plasmid pMPPla107, complete sequence	752164-752192	7	0.759
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP016890	Pantoea agglomerans strain C410P1 plasmid unnamed1, complete sequence	86872-86900	8	0.724
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP034470	Pantoea agglomerans strain CFSAN047153 plasmid pCFSAN047153_1, complete sequence	347233-347261	8	0.724
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	JX128258	Escherichia phage ECML-117, complete genome	55274-55302	8	0.724
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP034475	Pantoea agglomerans strain CFSAN047154 plasmid pCFSAN047154_1, complete sequence	459516-459544	8	0.724
NZ_CP024123_1	1.19\|1629924\|29\|NZ_CP024123\|CRT	1629924-1629952	29	NZ_CP031650	Pantoea agglomerans strain TH81 plasmid unnamed1, complete sequence	362396-362424	8	0.724
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	MN693553	Marine virus AFVG_25M446, complete genome	24142-24170	8	0.724
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	MN693421	Marine virus AFVG_25M197, complete genome	14115-14143	8	0.724
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	MN693283	Marine virus AFVG_25M198, complete genome	14152-14180	8	0.724
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	MN693381	Marine virus AFVG_25M224, complete genome	14258-14286	8	0.724
NZ_CP024123_1	1.22\|1630092\|29\|NZ_CP024123\|CRT	1630092-1630120	29	MN693277	Marine virus AFVG_25M240, complete genome	14085-14113	8	0.724
NZ_CP024123_1	1.25\|1630272\|29\|NZ_CP024123\|CRT	1630272-1630300	29	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	248550-248578	8	0.724
NZ_CP024123_1	1.25\|1630272\|29\|NZ_CP024123\|CRT	1630272-1630300	29	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	245724-245752	8	0.724

1. spacer 1.21|1630038|29|NZ_CP024123|CRT matches to NZ_CP020372 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence) position: , mismatch: 5, identity: 0.828

aatcggcgtcagcagtagcgtcagcatcg-	CRISPR spacer
gatcggcgtcagcagcagcatcag-ataga	Protospacer
.**************.***.**** ** *

2. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to MN693260 (Marine virus AFVG_25M320, complete genome) position: , mismatch: 6, identity: 0.793

agtcg--gcgtcagcagtagagttggcatcg	CRISPR spacer
--ttgatgcgtcagcagtagtggtggcatct	Protospacer
  *.*  ************* * *******

3. spacer 1.21|1630038|29|NZ_CP024123|CRT matches to NZ_CP016891 (Pantoea agglomerans strain C410P1 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.793

aatcggcgtcagcagtagcgtcagcatcg	CRISPR spacer
aggcagcgtcagcagtaccgtcagcagca	Protospacer
*. *.************ ******** *.

4. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013827 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15C-MedDCM-OCT-S33-C119, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.793

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgcaagt	Protospacer
*.********** *****.*******

5. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013811 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S36-C173, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.793

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgcaagt	Protospacer
*.********** *****.*******

6. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to JX519263 (Uncultured Mediterranean phage MEDS1 group fosmid MedDCM-OCT-S13-C2, complete sequence) position: , mismatch: 6, identity: 0.793

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgcaagt	Protospacer
*.********** *****.*******

7. spacer 1.23|1630146|29|NZ_CP024123|CRT matches to NZ_CP054621 (Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence) position: , mismatch: 6, identity: 0.793

agtcggcgtcagcagtagaatcagcgtca	CRISPR spacer
attcggcgtcagcagcagaagcagcgcgc	Protospacer
* *************.**** *****.

8. spacer 1.23|1630146|29|NZ_CP024123|CRT matches to MF370964 (Pseudoalteromonas phage SL20, complete genome) position: , mismatch: 6, identity: 0.793

agtcggcgtcagcagtagaatcagcgtca	CRISPR spacer
tagctgcgtcaccagtagaaacagcgtca	Protospacer
 . * ****** ******** ********

9. spacer 1.23|1630146|29|NZ_CP024123|CRT matches to AP013944 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S41-C114, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.793

agtcggcgtcagcagtagaatcagcgtca	CRISPR spacer
cggtgccgtcagctgtagaaacagcgtca	Protospacer
 * .* ******* ****** ********

10. spacer 1.23|1630146|29|NZ_CP024123|CRT matches to AP013933 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5-MedDCM-OCT-S40-C161, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.793

agtcggcgtcagcagtagaatcagcgtca	CRISPR spacer
cggtgccgtcagctgtagaaacagcgtca	Protospacer
 * .* ******* ****** ********

11. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP045721 (Pantoea eucalypti strain LMG 24197 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggcgtcagcagcagagttggcagat	Protospacer
.  ************.**********

12. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP034149 (Pantoea agglomerans strain L15 plasmid pPagL15_1, complete sequence) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggcgtcagcagcagagttggcagat	Protospacer
.  ************.**********

13. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP022517 (Pantoea vagans strain FBS135 plasmid pPant1, complete sequence) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggcgtcagcagcagagttggcagat	Protospacer
.  ************.**********

14. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to MN176217 (Escherichia phage vB_Eco4M-7, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
acattgcgtcagcagtagagacggcatca	Protospacer
*  . *************** .******.

15. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to MH051335 (Escherichia phage vB_EcoM-Ro157lw, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
acattgcatcagcagtagagtcggcatct	Protospacer
*  . **.*************.******

16. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NC_048194 (Escherichia phage vB_EcoM_WFH, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
acattgcatcagcagtagagtcggcatct	Protospacer
*  . **.*************.******

17. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NC_048195 (Escherichia phage vB_EcoM_WFC, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
acattgcgtcagcagtagagacggcatca	Protospacer
*  . *************** .******.

18. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NC_022916 (Burkholderia phage JG068, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
atgcggcgtcagcagtagacttagcagta	Protospacer
*  **************** **.*** ..

19. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to MT446408 (UNVERIFIED: Escherichia virus TH35, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
acattgcatcagcagtagagtcggcatct	Protospacer
*  . **.*************.******

20. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NC_048073 (Escherichia phage FEC19, complete genome) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
acattgcatcagcagtagagtcggcatct	Protospacer
*  . **.*************.******

21. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP014457 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S45-C173, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaac	Protospacer
*.********** *****.******

22. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013822 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15B-MedDCM-OCT-S24-C103, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaat	Protospacer
*.********** *****.******

23. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP014453 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S36-C132, *** SEQUENCING IN PROGRESS ***, 5 ordered pieces) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaat	Protospacer
*.********** *****.******

24. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013824 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15B-MedDCM-OCT-S29-C131, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaat	Protospacer
*.********** *****.******

25. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013823 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15B-MedDCM-OCT-S26-C119, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaat	Protospacer
*.********** *****.******

26. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013826 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15C-MedDCM-OCT-S23-C82, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaat	Protospacer
*.********** *****.******

27. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to MN693064 (Marine virus AFVG_25M35, complete genome) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctagt	Protospacer
*.********** *****.******

28. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to AP013807 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C15-MedDCM-OCT-S28-C82, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
catcagcatcagcagtaggatctgctaac	Protospacer
*.********** *****.******

29. spacer 1.23|1630146|29|NZ_CP024123|CRT matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

agtcggcgtcagcagtagaatcagcgtca	CRISPR spacer
gatcggcgtcagcagcagaaccagcaccg	Protospacer
..*************.****.****..*.

30. spacer 1.25|1630272|29|NZ_CP024123|CRT matches to NZ_CP031226 (Pseudomonas amygdali pv. lachrymans str. M301315 plasmid pMPPla107, complete sequence) position: , mismatch: 7, identity: 0.759

aattggaatcagcagtagcgtcagcatca	CRISPR spacer
tgctgtaatcagcagtagcgccagcacga	Protospacer
 ..** **************.*****. *

31. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP016890 (Pantoea agglomerans strain C410P1 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.724

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggtgtcagcagcagagttggcagat	Protospacer
.  ***.********.**********

32. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP034470 (Pantoea agglomerans strain CFSAN047153 plasmid pCFSAN047153_1, complete sequence) position: , mismatch: 8, identity: 0.724

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggtgtcagcagcagagttggcagat	Protospacer
.  ***.********.**********

33. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to JX128258 (Escherichia phage ECML-117, complete genome) position: , mismatch: 8, identity: 0.724

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gcattgcatcagcagtagagtcggcatct	Protospacer
.  . **.*************.******

34. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP034475 (Pantoea agglomerans strain CFSAN047154 plasmid pCFSAN047154_1, complete sequence) position: , mismatch: 8, identity: 0.724

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggtgtcagcagcagagttggcagat	Protospacer
.  ***.********.**********

35. spacer 1.19|1629924|29|NZ_CP024123|CRT matches to NZ_CP031650 (Pantoea agglomerans strain TH81 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.724

agtcggcgtcagcagtagagttggcatcg	CRISPR spacer
gtgcggtgtcagcagcagagttggcagat	Protospacer
.  ***.********.**********

36. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to MN693553 (Marine virus AFVG_25M446, complete genome) position: , mismatch: 8, identity: 0.724

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
aatcagcagcagaagtagaagctgctgtt	Protospacer
 .****** *********** ****  .

37. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to MN693421 (Marine virus AFVG_25M197, complete genome) position: , mismatch: 8, identity: 0.724

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
aatcagcagcagaagtagaagctgctgtt	Protospacer
 .****** *********** ****  .

38. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to MN693283 (Marine virus AFVG_25M198, complete genome) position: , mismatch: 8, identity: 0.724

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
aatcagcagcagaagtagaagctgctgtt	Protospacer
 .****** *********** ****  .

39. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to MN693381 (Marine virus AFVG_25M224, complete genome) position: , mismatch: 8, identity: 0.724

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
aatcagcagcagaagtagaagctgctgtt	Protospacer
 .****** *********** ****  .

40. spacer 1.22|1630092|29|NZ_CP024123|CRT matches to MN693277 (Marine virus AFVG_25M240, complete genome) position: , mismatch: 8, identity: 0.724

cgtcagcatcagaagtagaatctgcatcg	CRISPR spacer
aatcagcagcagaagtagaagctgctgtt	Protospacer
 .****** *********** ****  .

41. spacer 1.25|1630272|29|NZ_CP024123|CRT matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 8, identity: 0.724

aattggaatcagcagtagcgtcagcatca	CRISPR spacer
gcctggaatcagcagcagcggcagcacgg	Protospacer
. .************.**** *****. .

42. spacer 1.25|1630272|29|NZ_CP024123|CRT matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 8, identity: 0.724

aattggaatcagcagtagcgtcagcatca	CRISPR spacer
gcctggaatcagcagcagcggcagcacgg	Protospacer
. .************.**** *****. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1072352 : 1078486

Streptococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099422871.1\|1072352_1073462_+	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES46	Bathycoccus_sp._RCC1105_virus	4.6e-12	25.3
WP_099422872.1\|1073962_1074853_+	glucose-1-phosphate thymidylyltransferase RfbA	A0A1D7XFC1	Escherichia_phage	5.3e-96	60.2
WP_099422873.1\|1074897_1075917_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	2.0e-78	47.0
WP_099422874.1\|1076113_1076830_+	capsular biosynthesis protein	A0A1X9I5E1	Streptococcus_phage	4.4e-16	29.0
WP_172954421.1\|1076855_1077554_+	CpsD/CapB family tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	7.8e-26	35.9
WP_099422875.1\|1077743_1078010_+	stage V sporulation protein S	J9PTX7	Bacillus_phage	3.9e-10	41.0
WP_099422876.1\|1078204_1078486_+	stage V sporulation protein S	J9PTX7	Bacillus_phage	2.4e-10	41.0

DBSCAN-SWA_2

2053058 : 2109102

Leuconostoc_phage(14.29%)

transposase,integrase,protease

attL 2048327:2048341|attR 2054544:2054558

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2048327:2048341	attL	NA	NA	NA	NA
WP_099423737.1\|2053058_2053574_+\|integrase	tyrosine-type recombinase/integrase	E3W8I1	Leuconostoc_phage	2.1e-07	31.8
WP_099423738.1\|2053957_2054899_-	DUF3307 domain-containing protein	NA	NA	NA	NA
2054544:2054558	attR	NA	NA	NA	NA
WP_099423739.1\|2054900_2055653_-	hypothetical protein	NA	NA	NA	NA
WP_099423740.1\|2055933_2056356_-	ester cyclase	NA	NA	NA	NA
WP_099423741.1\|2057123_2057777_-	ABC-2 transporter permease	NA	NA	NA	NA
WP_099423742.1\|2057777_2058629_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.1e-21	31.1
WP_099423743.1\|2059051_2060338_+	helix-turn-helix domain-containing protein	K7P850	Enterobacteria_phage	6.3e-05	40.0
WP_099423744.1\|2060567_2061407_-	hypothetical protein	NA	NA	NA	NA
WP_099423745.1\|2061422_2062619_-	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_099423746.1\|2062716_2064219_-	long-chain fatty acid--CoA ligase	Q75ZG1	Hepacivirus	2.3e-43	28.5
WP_099423747.1\|2064232_2064817_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_099423748.1\|2064826_2065975_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_099423749.1\|2066513_2067101_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_099425803.1\|2067405_2067636_-	hypothetical protein	NA	NA	NA	NA
WP_099423750.1\|2067955_2068237_-	hypothetical protein	NA	NA	NA	NA
WP_099423751.1\|2068776_2069337_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_099423752.1\|2069674_2070064_-	hypothetical protein	NA	NA	NA	NA
WP_099423753.1\|2070224_2070680_-	hypothetical protein	NA	NA	NA	NA
WP_099423754.1\|2070896_2071784_-	anti-sigma-V factor rsiV	NA	NA	NA	NA
WP_099423755.1\|2071786_2072281_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_099423756.1\|2072775_2072994_-	DUF3923 family protein	NA	NA	NA	NA
WP_099423757.1\|2073168_2073627_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_157764784.1\|2073845_2074385_-	hypothetical protein	NA	NA	NA	NA
WP_099423759.1\|2074659_2074971_-	hypothetical protein	NA	NA	NA	NA
WP_099423760.1\|2075099_2075504_-	hypothetical protein	NA	NA	NA	NA
WP_172954375.1\|2076511_2077978_-	HAMP domain-containing histidine kinase	Q6XLV6	Feldmannia_irregularis_virus	1.7e-06	33.7
WP_099423764.1\|2077965_2078646_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.4e-35	36.3
WP_157764785.1\|2078889_2080113_+	DUF418 domain-containing protein	NA	NA	NA	NA
WP_099423766.1\|2080468_2080834_-	hypothetical protein	NA	NA	NA	NA
WP_157764786.1\|2080885_2081053_-	hypothetical protein	NA	NA	NA	NA
WP_099423767.1\|2081149_2081443_-	hypothetical protein	NA	NA	NA	NA
WP_099423768.1\|2081640_2081949_-	hypothetical protein	NA	NA	NA	NA
WP_099423704.1\|2082730_2084008_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_099423769.1\|2084249_2084642_-	topoisomerase	NA	NA	NA	NA
WP_099425804.1\|2085402_2085939_-	HAD family hydrolase	NA	NA	NA	NA
WP_099423770.1\|2086730_2087294_-	hypothetical protein	NA	NA	NA	NA
WP_157764787.1\|2087960_2088134_+	hypothetical protein	NA	NA	NA	NA
WP_099423771.1\|2089190_2089754_-	signal peptidase I	NA	NA	NA	NA
WP_099423772.1\|2089918_2090575_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099423773.1\|2090794_2091301_-	GrpB family protein	A0A2K5B2B6	Erysipelothrix_phage	2.9e-14	34.4
WP_099423774.1\|2091427_2091658_-	hypothetical protein	NA	NA	NA	NA
WP_099423775.1\|2091807_2092611_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_099423776.1\|2092999_2093191_-	hypothetical protein	NA	NA	NA	NA
WP_099423704.1\|2093654_2094932_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_099423777.1\|2095111_2096158_-	DUF1835 domain-containing protein	NA	NA	NA	NA
WP_099423778.1\|2096350_2097145_-	aminoglycoside phosphotransferase family protein	NA	NA	NA	NA
WP_099423779.1\|2097227_2097485_-	hypothetical protein	NA	NA	NA	NA
WP_099423780.1\|2097645_2098074_-	hypothetical protein	NA	NA	NA	NA
WP_167395904.1\|2098296_2098455_-	hypothetical protein	NA	NA	NA	NA
WP_099423781.1\|2098557_2098947_-	hypothetical protein	NA	NA	NA	NA
WP_099423782.1\|2099388_2100666_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_099423783.1\|2101107_2101956_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_099423784.1\|2102078_2103314_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_099423785.1\|2103554_2104202_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_099423786.1\|2104498_2104615_-	hypothetical protein	NA	NA	NA	NA
WP_157764788.1\|2105408_2105564_-	hypothetical protein	NA	NA	NA	NA
WP_099423789.1\|2106298_2106928_-	DUF3885 domain-containing protein	NA	NA	NA	NA
WP_099423790.1\|2107000_2107387_-	DUF5071 domain-containing protein	NA	NA	NA	NA
WP_099423791.1\|2107824_2109102_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2457795 : 2471607

uncultured_Caudovirales_phage(38.46%)

tail,terminase,head,capsid,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099424113.1\|2457795_2458140_-	hypothetical protein	A0A1X9I607	Streptococcus_phage	6.6e-18	42.9
WP_157764807.1\|2458155_2461242_-	hypothetical protein	A0A218MKN2	uncultured_virus	7.9e-30	37.8
WP_099424115.1\|2461192_2461525_-	hypothetical protein	NA	NA	NA	NA
WP_099424116.1\|2461578_2461935_-	hypothetical protein	NA	NA	NA	NA
WP_099425827.1\|2461989_2462508_-	hypothetical protein	NA	NA	NA	NA
WP_099424117.1\|2462657_2463077_-\|tail	phage tail protein	A0A1X9I6R2	Streptococcus_phage	9.4e-27	50.4
WP_099424118.1\|2463092_2463446_-	hypothetical protein	A0A2H4JDU4	uncultured_Caudovirales_phage	8.2e-08	33.1
WP_099424119.1\|2463446_2463887_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_099424120.1\|2463889_2464213_-	hypothetical protein	A0A2H4J6Q5	uncultured_Caudovirales_phage	6.2e-10	30.6
WP_099424121.1\|2464202_2464517_-\|head,tail	phage head-tail connector protein	A0A2H4JD74	uncultured_Caudovirales_phage	3.2e-11	40.0
WP_157764808.1\|2464545_2464707_-	hypothetical protein	NA	NA	NA	NA
WP_099424122.1\|2464721_2465744_-\|capsid	major capsid protein	S5MA55	Brevibacillus_phage	2.3e-135	71.7
WP_099424123.1\|2465771_2466083_-	hypothetical protein	S5M669	Brevibacillus_phage	6.5e-25	58.8
WP_099425828.1\|2466098_2466773_-	DUF4355 domain-containing protein	A0A2H4J4U9	uncultured_Caudovirales_phage	3.1e-11	42.7
WP_099424124.1\|2467085_2468129_-\|capsid	minor capsid protein	A0A2H4J4W7	uncultured_Caudovirales_phage	2.3e-61	35.1
WP_099424125.1\|2468112_2469492_-\|portal	phage portal protein	D7RWI5	Brochothrix_phage	1.4e-98	44.6
WP_099424126.1\|2469496_2470831_-\|terminase	PBSX family phage terminase large subunit	A0A1B1UZZ1	Enterococcus_phage	6.2e-157	63.5
WP_099424127.1\|2470830_2471607_-	hypothetical protein	A0A1L2JY44	Aeribacillus_phage	8.6e-58	57.4

DBSCAN-SWA_4

2480825 : 2487261

Listeria_phage(33.33%)

integrase

attL 2476557:2476572|attR 2489228:2489243

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2476557:2476572	attL	NA	NA	NA	NA
WP_099424140.1\|2480825_2481626_-	recombinase RecT	S6AVW6	Thermus_phage	6.6e-61	49.5
WP_099424141.1\|2481629_2482568_-	YqaJ viral recombinase family protein	A8ATY5	Listeria_phage	4.6e-82	50.2
WP_099424142.1\|2482641_2482920_-	hypothetical protein	NA	NA	NA	NA
WP_172954436.1\|2483207_2483498_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_099424144.1\|2483690_2483999_-	hypothetical protein	NA	NA	NA	NA
WP_172954385.1\|2484042_2484735_-	ORF6C domain-containing protein	A5GZ67	Lactococcus_phage	1.5e-32	35.3
WP_099424146.1\|2484761_2485022_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_099424147.1\|2485177_2485591_+	helix-turn-helix transcriptional regulator	A8ATJ9	Listeria_phage	9.9e-29	48.1
WP_099424148.1\|2485619_2486048_+	ImmA/IrrE family metallo-endopeptidase	Q9T201	Bacillus_phage	1.0e-28	48.9
WP_099424149.1\|2486094_2487261_+\|integrase	site-specific integrase	A0A1Q1PVS7	Staphylococcus_phage	2.4e-35	29.8
2489228:2489243	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2553176 : 2610576

Staphylococcus_phage(22.22%)

transposase,integrase,protease

attL 2575657:2575683|attR 2617396:2617422

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099423704.1\|2553176_2554454_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_157764814.1\|2554962_2555802_+	ROK family protein	NA	NA	NA	NA
WP_099424216.1\|2557518_2558460_-	WYL domain-containing protein	NA	NA	NA	NA
WP_099423704.1\|2558665_2559943_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_099424217.1\|2560540_2561152_+	Type 1 glutamine amidotransferase-like domain-containing protein	NA	NA	NA	NA
WP_099424219.1\|2561851_2562244_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099424220.1\|2564679_2565153_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_099424221.1\|2565288_2565873_+	DUF3238 domain-containing protein	NA	NA	NA	NA
WP_099424222.1\|2565922_2566549_+	FMN-dependent NADH-azoreductase	NA	NA	NA	NA
WP_099424223.1\|2568087_2568684_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_099424224.1\|2568748_2569891_+	MFS transporter	NA	NA	NA	NA
WP_099424225.1\|2570831_2571815_+	GMP reductase	G3MBI2	Bacillus_virus	6.0e-157	84.1
WP_157764815.1\|2573929_2574289_-	DUF3139 domain-containing protein	NA	NA	NA	NA
WP_099424228.1\|2574974_2575523_-	hypothetical protein	NA	NA	NA	NA
2575657:2575683	attL	NA	NA	NA	NA
WP_099424229.1\|2575848_2577018_-	MFS transporter	NA	NA	NA	NA
WP_099424230.1\|2577165_2578176_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_099424231.1\|2578311_2579205_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_099424232.1\|2579586_2580132_-	peptide deformylase	M4SLL3	Cyanophage	4.4e-08	33.3
WP_099424233.1\|2580124_2580316_-	helix-turn-helix transcriptional regulator	I3VYZ1	Thermoanaerobacterium_phage	2.4e-06	46.4
WP_099424234.1\|2581906_2582647_+	SDR family NAD(P)-dependent oxidoreductase	A0A0M4JSW6	Mollivirus	1.2e-13	26.3
WP_099424235.1\|2583026_2583413_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_099424236.1\|2583474_2584386_-	YafY family transcriptional regulator	A0A1B0RXM1	Streptococcus_phage	6.0e-10	31.4
WP_099424237.1\|2584783_2585725_-	WYL domain-containing protein	NA	NA	NA	NA
WP_099424238.1\|2586047_2586659_+	Type 1 glutamine amidotransferase-like domain-containing protein	NA	NA	NA	NA
WP_099424239.1\|2587103_2587601_-	ATP-binding protein	A0A1Q1PVZ2	Staphylococcus_phage	2.3e-56	62.4
WP_099424240.1\|2587934_2588288_-	DUF3147 family protein	NA	NA	NA	NA
WP_099424241.1\|2588278_2588695_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_099424242.1\|2590160_2590430_-	hypothetical protein	NA	NA	NA	NA
WP_099424243.1\|2590747_2591290_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_157764816.1\|2591286_2591727_+	zf-HC2 domain-containing protein	NA	NA	NA	NA
WP_099424245.1\|2591729_2592830_+	hypothetical protein	NA	NA	NA	NA
WP_099424246.1\|2592822_2593773_+	exosporium protein E	NA	NA	NA	NA
WP_099423462.1\|2594161_2594548_-	UPF0715 family protein	NA	NA	NA	NA
WP_099424247.1\|2595056_2595581_-	hypothetical protein	NA	NA	NA	NA
WP_099424248.1\|2595831_2596119_-	hypothetical protein	NA	NA	NA	NA
WP_099424249.1\|2596506_2597472_-	hypothetical protein	NA	NA	NA	NA
WP_099424250.1\|2598170_2598737_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_099424251.1\|2599078_2599537_-	hypothetical protein	NA	NA	NA	NA
WP_099424253.1\|2600039_2600468_-	hypothetical protein	NA	NA	NA	NA
WP_099424254.1\|2600732_2601248_-	hypothetical protein	NA	NA	NA	NA
WP_099424255.1\|2601649_2602735_-	DUF4179 domain-containing protein	NA	NA	NA	NA
WP_099424256.1\|2602718_2603282_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_099424258.1\|2604472_2604973_-	NUDIX hydrolase	NA	NA	NA	NA
WP_099424259.1\|2605567_2605930_-	hypothetical protein	NA	NA	NA	NA
WP_099424260.1\|2606927_2607773_-\|integrase	tyrosine-type recombinase/integrase	A0A0K2CP59	Brevibacillus_phage	2.7e-20	27.2
WP_099424261.1\|2607777_2609658_-\|integrase	tyrosine-type recombinase/integrase	Q4ZE80	Staphylococcus_phage	2.5e-10	25.4
WP_099424262.1\|2609742_2610576_-\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	2.5e-15	26.2
2617396:2617422	attR	NA	NA	NA	NA

DBSCAN-SWA_6

3889112 : 3897445

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099425372.1\|3889112_3889679_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.3e-25	38.2
WP_099425373.1\|3889678_3890734_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	1.2e-62	44.0
WP_099425374.1\|3890848_3892267_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	9.9e-52	32.7
WP_099425375.1\|3892242_3894480_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.2e-149	39.4
WP_099425376.1\|3894466_3895150_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_099425377.1\|3895153_3895399_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_099425378.1\|3895402_3896113_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	1.4e-51	42.8
WP_099425379.1\|3896143_3897445_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	7.2e-17	30.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage