CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021849	Enterococcus faecium strain 16-346 chromosome, complete genome	1 crisprs	cas3,csa3,DEDDh,RT,cas14j	0	0	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021849_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021849_1

2504203-2504312

Orphan

Consensus_repeat	Method
CTTTGCTCAACCAGTATTATTCATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021849_1

>merge|NZ_CP021849|1|2504203-2504312|CRISPRCasFinder
CTTTGCTCAACCAGTATTATTCATCACCTATTCACTTCGTTCATAGTGATTCTACTCGCTTTGCTCGAAAGGAAACTCCTTTCGCTTTGCTCAACCAGTATTGTTCATCA

>NZ_CP021849|1|1|2504203-2504312|CRISPRCasFinder
CTTTGCTCAACCAGTATTATTCATCA	CCTATTCACTTCGTTCATAGTGATTCTACTCGCTTTGCTCGAAAGGAAACTCCTTTCG
CTTTGCTCAACCAGTATTGTTCATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021849.1\|WP_002294577.1\|2511051_2511696_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341358
NZ_CP021849.1\|WP_002294584.1\|2506778_2507651_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NZ_CP021849.1\|WP_002294585.1\|2506097_2506766_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NZ_CP021849.1\|WP_002294579.1\|2510543_2510714_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|376355
NZ_CP021849.1\|WP_002294589.1\|2502410_2503100_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_CP021849.1\|WP_002287792.1\|2495000_2495966_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|275027
NZ_CP021849.1\|WP_002287787.1\|2498469_2499171_-\|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl\|CDD\|238693
NZ_CP021849.1\|WP_002294580.1\|2509897_2510443_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP021849.1\|WP_002294593.1\|2496054_2497194_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP021849.1\|WP_002290558.1\|2499404_2500937_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP021849.1\|WP_002303469.1\|2492791_2494951_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|180921
NZ_CP021849.1\|WP_002287788.1\|2497502_2498216_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP021849.1\|WP_002291634.1\|2503626_2504130_-\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_CP021849.1\|WP_002294578.1\|2510737_2510890_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP021849.1\|WP_002294588.1\|2503205_2503574_-\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_CP021849.1\|WP_002294581.1\|2508933_2509821_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|283645
NZ_CP021849.1\|WP_002291638.1\|2505332_2505755_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_CP021849.1\|WP_002294587.1\|2504539_2505229_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_CP021849.1\|WP_002294583.1\|2507741_2508761_-\|L-lactate-oxidase	unknown	unknown	gnl\|CDD\|240088
NZ_CP021849.1\|WP_002287795.1\|2492408_2492633_+\|glutaredoxin-like-protein-NrdH	unknown	unknown	gnl\|CDD\|131249

Protein	Function_ID	Function_description	E-value
NZ_CP021849.1\|WP_002294577.1\|2511051_2511696_+\|CBS-domain-containing-protein	gnl\|CDD\|341358	cd02205, CBS_pair_SF, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	5.69774e-14
NZ_CP021849.1\|WP_002294584.1\|2506778_2507651_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	2.63238e-103
NZ_CP021849.1\|WP_002294585.1\|2506097_2506766_+\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.41351e-73
NZ_CP021849.1\|WP_002294579.1\|2510543_2510714_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	1.48e-13
NZ_CP021849.1\|WP_002294589.1\|2502410_2503100_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	3.65546e-19
NZ_CP021849.1\|WP_002287792.1\|2495000_2495966_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|275027	TIGR04171, ribonucleotide-diphosphate_reductase_subunit_beta, ribonucleoside-diphosphate reductase, class 1b, beta subunit. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
NZ_CP021849.1\|WP_002287787.1\|2498469_2499171_-\|glucosamine-6-phosphate-deaminase	gnl\|CDD\|238693	cd01399, GlcN6P_deaminase, GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.	8.8122e-119
NZ_CP021849.1\|WP_002294580.1\|2509897_2510443_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	1.97252e-86
NZ_CP021849.1\|WP_002294593.1\|2496054_2497194_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.46227e-61
NZ_CP021849.1\|WP_002290558.1\|2499404_2500937_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	5.56109e-170
NZ_CP021849.1\|WP_002303469.1\|2492791_2494951_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|180921	PRK07306, PRK07306, ribonucleotide-diphosphate reductase subunit alpha; Validated.	0
NZ_CP021849.1\|WP_002287788.1\|2497502_2498216_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	6.15701e-49
NZ_CP021849.1\|WP_002291634.1\|2503626_2504130_-\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	3.03735e-67
NZ_CP021849.1\|WP_002294578.1\|2510737_2510890_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	3.12722e-17
NZ_CP021849.1\|WP_002294588.1\|2503205_2503574_-\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	5.30333e-45
NZ_CP021849.1\|WP_002294581.1\|2508933_2509821_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|283645	pfam06028, DUF915, Alpha/beta hydrolase of unknown function (DUF915). This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	4.81944e-80
NZ_CP021849.1\|WP_002291638.1\|2505332_2505755_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	9.059e-96
NZ_CP021849.1\|WP_002294587.1\|2504539_2505229_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.66496e-146
NZ_CP021849.1\|WP_002294583.1\|2507741_2508761_-\|L-lactate-oxidase	gnl\|CDD\|240088	cd04737, LOX_like_FMN, L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate dehydrogenase (MDH), and long chain hydroxyacid oxidase (LCHAO).	0
NZ_CP021849.1\|WP_002287795.1\|2492408_2492633_+\|glutaredoxin-like-protein-NrdH	gnl\|CDD\|131249	TIGR02194, Glutaredoxin-like_protein_NrdH, Glutaredoxin-like protein NrdH. NrdH-redoxin is a representative of a class of small redox proteins that contain a conserved CXXC motif and are characterized by a glutaredoxin-like amino acid sequence and thioredoxin-like activity profile. Unlike other the glutaredoxins to which it is most closely related, NrdH aparrently does not interact with glutathione/glutathione reductase, but rather with thioredoxin reductase to catalyze the reduction of ribonucleotide reductase.	1.21827e-35

>NZ_CP021849.1|WP_002291634.1|2503626_2504130_-|50S-ribosomal-protein-L10
MSEAIIAKKAAIVDEVSEKFTAAASVVVVDYRGLTVDEVTRLRKQLRDANVEMKVIKNSILSRAAKKAGLEGMDEVFTGPTAVAFSNEDVVAPAKIMDEFAKEAKALEIKGGIIEGKVSSLEEITALAKLPNREGLLSMLLSVLQAPVRNVAYAVKAVADKEDGDAA
>NZ_CP021849.1|WP_002294588.1|2503205_2503574_-|50S-ribosomal-protein-L7/L12
MALNIENIVAELKEATILELNDLVKAIEEEFGVSAAAPVAVAAAGGAAAAEEQTEFTVELTAAGDQKVKVIKAVREATGLGLKEAKAVVDGAPAPVKEGVSKEEAEELKAKLEEVGASVTVK
>NZ_CP021849.1|WP_002294589.1|2502410_2503100_-|TVP38/TMEM64-family-protein
MKKKIIRLILISLGIILILVVGYRLYLEYQTDIQLFLNPRASKAELLAHIRSHGTFASILLIVLTAVMCAVPGIPTSVVGVIAGLSFGPLTGAIINILGNALGNITAIFLMHRLKFLDKKTETNHWVQAIRQMKHPKIGVMLGYMIPVIPSSMVNFAADAMKLPLQQIILSIVIGVIPSSVLYACGGEALFHGYNKTAVTLVASVTVLVGLVVFIYKDRKKKQGKQKHK
>NZ_CP021849.1|WP_002290558.1|2499404_2500937_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSILTLNNITQQFGDKILYEGVDLQLNAGEHLGLIGQNGAGKSTLIKIITGEILPDDGQIHWQKNIHKGYLDQYVEVDETLTIEEFLKTAYAKEYEKEEKIAFLYQTYSETFDDSLLEKAGKLQTELDQGVFYQIDTLVAEMSSGLGIDVLGLDSLLKNLSGGQRSKVILAKLLLENPDVLILDEPTNHLDDQHIQWLTQFLQDFDGAYIVISHDQEFLDQITTHIADIEFGKITKYTGHLKQALKQKEQNRESYLRQYHAQQKQIEKTEAYIRKYKAGSRSTMAKSRQKQLDKIERLTPPASASKAVFDFPFSPIVTTLAVETTDLVIGYDRPLLAPINLTIRFGENIAIRGFNGIGKSTLLKTLIGEIEKISGDFHFPDNTKINYFSQDLYWENPLETPLQYLSSQFPKATIKELRRQLAKAGLVNQLASEPLTTLSGGEQTKVKLAQLTMNQGNLLILDEPTNHIDQETKESLQDGIQKFPGTVIIVSHEQEFYQDLVQRVIEIEPK
>NZ_CP021849.1|WP_002287787.1|2498469_2499171_-|glucosamine-6-phosphate-deaminase
MEIIRVKNAEEGGKKAFEIIKEGMNKGAKVLGLATGSTPVTLYKEMTSSDLDFSEMTSVNLDEYVGLGGSDEQSYRHFMDVQLFDKKPFKETFVPDGKAEDLEAACKKYDQIIDAHPIDIQILGIGQNGHIGFNEPGASFDGTTSVVDLTESTINANKRFFDKAEDVPTKAVSMGIGSIMKSKEIVLMAFGESKADAIKGMIEGPVTNHLPASVLQNHDNVVVIIDEEAASKL
>NZ_CP021849.1|WP_002287788.1|2497502_2498216_-|MgtC/SapB-family-protein
MNDMVLTIPEIILRLGIAMLFGGAIGFERQYKNRPAGMRTHILVCMGACIIALIQVEIASGALRDALEYPQLAGTIRSDEARLIAQVVSGVGFLGAGTIIVTKQSVTGLTTAASLWAIAGLGIAIGMGYYSIAIISFIGIAIALTVVKRVIHVPTTKKLEIQFIHRKETKDFLTDYFEEKNIVIEDVNFDVKFVDDYRVYKNIYTIDLPKGLTYADVIEELSVHKNITKLHLVSIAQ
>NZ_CP021849.1|WP_002294593.1|2496054_2497194_-|AI-2E-family-transporter
MQSRFKQSKLFFWTVELVLTIIGVYFILQMPNIFSPILKMLSAVFLPLLVAGFIYYMFDPIVVFLEKHRIPRVFGFLLTFLVVIILVVLTVMNVVPQLMEQTIQLTQSLPMYADETSKWLNELAQREEFKNFNLEEQLASANLSLSNLFNIILVSLSASVSKIISFMMQFFILLFTVPFILLFMFKDGHKFIDALSHFFPKAIRKELRQTVKELNETLSAYISSTILDALIIGVMSFLAMRIFDQPYSLLLAVICGITNIIPYVGPFIGAVPAIIVGLFISPFQALYMALSILVIQQLDGNLIKPLLFGKSMNIHPLTIILVLIGAGSVAGILGMLICIPVYAVIKTIILNIRKIYLLRRMEHVSEKLDSPKVLEETSE
>NZ_CP021849.1|WP_002287792.1|2495000_2495966_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MSETYYEAINWNEIEDIIDKSTWEKLTEQFWLDTRIPLSNDLDDWRTLSQLEKDTVGHVFGGLTLLDTVQSESGMDQLRKDVRTPHEEAVLNNIQFMESVHAKSYSSIFSTLNTKKEIEEIFDWTNTNPYLQKKAERINEIYKHGTPLEKKIASVFLETFLFYSGFYTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEAEQETLKDWMYNLLYELYENEERYTEELYDPIGWTEEVKTFLRYNANKALMNLGMDPLFPDTANDVNPIVMNGISTGTSNHDFFSQVGNGYLLGHVEAMKDDDYLIGLE
>NZ_CP021849.1|WP_002303469.1|2492791_2494951_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MSLKNLQDVSYFKLNNEINRPVNGQIPLNKDKEALVAFFEENVKPNTMTFLSIMEKINYLIDQEYIEAEFIQLYSPSFIEKLYQFLDEQHFSFKSFMAAYKFYSQYALKTNDGSAYLETYEDRVAFNALYFANGDEELALALADEMIHQRYQPATPSFLNAGRKRRGELVSCFLTQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYEGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRKNEDMYLFSPYSVEKEYGVPFSYVNITAEYDHLVANPNIRKQKIKARDLENEISKLQQESGYPYVINIDTANRENPIDGKIIMSNLCSEILQVQTPSVINGKQEYEVLGTDISCNLGSTNIVNLMQSPNFGQSVRTMTRALTFITDASDIDVVPPIQNGNKLNHTIGLGAMGLHTYLAKEQMEYGSEDSLDFTNIYFMLLNYWTLVESNNIARERKQVFHNFEKSAYADGTYFEKYVTGEFQPKSEKVKALFEGIFIPTAEDWNALKQAVMKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKIGKIYYPAPYLSNETIPYYTSAYDMDMRKVIDVYAMAQQHVDQGMSLTLFMRSEIPEGIYEWKTTTKQTTRDLNILRHYAFHKGIKSIYYVRTFTDDAEEIGSNQCESCVI
>NZ_CP021849.1|WP_002287795.1|2492408_2492633_+|glutaredoxin-like-protein-NrdH
MNVKIFSKNNCMQCKMVKRFLTENQIAFEEVNIDEQPEAVDWLKAQGFQSVPVITSDAETVIGFRPDQLRKLAS
>NZ_CP021849.1|WP_002294587.1|2504539_2505229_-|50S-ribosomal-protein-L1
MAKKSKKMQDALKKVDSSKVYPVAEAVALAKETNIAKFDATVEVAYRLNVDPKKADQQIRGAVVLPNGTGKTQTVLVFAKGDKAKEAEAAGADFVGDDDMVQKIQNGWFDFDVVVATPDMMATVGRLGRVLGPKGLMPNPKTGTVTMDVTKAVNEVKAGKVTYRVDKAGNIHVPIGKVSFDDEKLVENFAAIHDVLLKAKPSAAKGQYMKNVTITTTFGPGIHVDQASF
>NZ_CP021849.1|WP_002291638.1|2505332_2505755_-|50S-ribosomal-protein-L11
MAKKVEKIVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGLIIPVVISVYEDRSFTFVTKTPPAAVLLKKAAKIEKGSGEPNKNKVAKVSSDQVREIAELKMEDLNAANVEAAMRMVEGTARSMGITVE
>NZ_CP021849.1|WP_002294585.1|2506097_2506766_+|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKDLRYRSVFDIIGPVMIGPSSSHTAGAARIGKIIRSIFGEQPDSVDIYLYESFAKTYRGHGTDIALVGGLLGMEPDDERLADSLKLAYEAGMEVLFVPKSEKAEHPNSVKMLLKKGTRKLSVTGISIGGGNIQISELNGFKISLSMGTPTLIVVHQDVPGMIAKVTSILSETNTNIGTMTVTRESKGENAIMIIEVDDPQVEETVKRLKQLPNIDSVNYFD
>NZ_CP021849.1|WP_002294584.1|2506778_2507651_+|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFLSIEELVDQAKAYPSVAELMIAVEMEMSGRSRSHIIEIMEKNLSVMEQSINEGKEGVTSVTGITGGDAKKLDDYLNEADFLSGETILKAVRNAVAVNEVNAKMGLICATPTAGSAGVVPGVLMAVRDRLDLTHEQQLEFLFTAGAFGLVIANNASISGAEGGCQAEVGSASAMAAAALVCAKNGTPHQAAQAVAITLKNMMGLICDPVAGLVEVPCVKRNALGSSQAFISADMALAGIESVIPPDEVVAAMYQVGRQMPSIFKETAEGGLAVTPTAKRLAEEILNKRA
>NZ_CP021849.1|WP_002294583.1|2507741_2508761_-|L-lactate-oxidase
MEAGAFGYIRGGSEDEWTMKENTTSFNTKKIMPRILRGIDSADLHTSVFGIELDTPIIQAPSAAQGLAHEKGEADTAKGVAAAGSIFSISTYANTTIKDAADAAPGAPQFFQLYMSKDDRFNEFILNKAVEAGAKAIILTADSTLGGYREEDVINQFQFPLPMPNLAAYSEQSASGNGEGKGIAEIYAAAKQGLTPDDIKTIKEITHLPVIVKGIQSPEDAVIAISAGADGIWVSNHGGRQLDGGPASFEVLPKIAEVVNKRVPVIFDSGVRRGEHVFKALASGADLVAIGRPVIYGLNLGGAEGVTSVFEHLNKELSITMQLAGTKTIDEVKNTKLMD
>NZ_CP021849.1|WP_002294581.1|2508933_2509821_-|alpha/beta-fold-hydrolase
MTEPIKNLCKRATAAALVLISLFALSGCQTTKINTTEVSDKEKTAESSKVIEKTTIPTLFFHGYSGTENSFKGMLRRLEKNQQAVKELVLTVGTDGQIQATGDLSGKADNPMVQVLFEDNKNNEWNQAEWIKTCLLYLKENYGIDKVNIVGHSMGGVSALRYLGTYGQDTSLPQVQTLTAIGAPFNDFVDDSAQSLTDELAKGPAVVSNRYQDYQQMIGNIPITTRFFLIAGQLDETDLSDGTVPLNSALAVYALLKQRGNEIEEKVVTGENASHSMLHENQEVDQLVSRFIWKE
>NZ_CP021849.1|WP_002294580.1|2509897_2510443_-|transcription-termination/antitermination-protein-NusG
MESFEKNWYVLHTYSGYENKVKANIESRAQSMKMADFIFRVVVPEEKETEVKNGKEKEIVHKTFPGYVLVEMIMTDASWYVVRNTPGVTGFVGSHGAGSKPAPLLPEEVNHILRSIGMSLRQNDLEVEVGEVVKIIEGAFAGLEGQVTEVDGEKEKLKVNIDMFGRETSTELDFDQVDKID
>NZ_CP021849.1|WP_002294579.1|2510543_2510714_-|preprotein-translocase-subunit-SecE
MKFLKSVKDEIKQVTWPSRKQLRKDTLVVIETSIIFGLMFYVMDTAIQSLFGWILK
>NZ_CP021849.1|WP_002294578.1|2510737_2510890_-|50S-ribosomal-protein-L33
MAKKKAALACSVCGSRNYTKSVSEGKSGERLEINKFCKYCNQYTLHKETK
>NZ_CP021849.1|WP_002294577.1|2511051_2511696_+|CBS-domain-containing-protein
MLLKTLVYKKKDLTTVTETSTLEEALKILETSGYRCVPILDSSGNIFRGNIYKMHIYRHKANGGDMTLPVTHLLKNATKFIYLDTSFFKVFFTIKELPYIAVLDSENHFYGILTHSTLLNMLSQSWSVEQGSYVLTIASTGKQGDLAAIAKIISKHSSIASCITLDIEKDEYIRRTLITLPANTEAKVCETIVNHLEKKNYKVVEIENLQNQEA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

320783 : 329844

Gordonia_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002288023.1\|320783_322079_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	4.5e-19	33.1
WP_002297115.1\|322258_322636_-	hypothetical protein	NA	NA	NA	NA
WP_002288021.1\|322891_323620_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	4.6e-45	41.4
WP_002295474.1\|323619_323874_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002288017.1\|323875_324547_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_002288015.1\|324547_326770_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.9e-150	41.3
WP_002288013.1\|326754_328194_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.3e-53	33.1
WP_002321731.1\|328225_329269_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	2.7e-62	43.7
WP_002288010.1\|329265_329844_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-26	37.4

DBSCAN-SWA_2

767288 : 875485

111

Enterococcus_phage(52.38%)

plate,terminase,holin,integrase,capsid,portal,tail,protease,head,tRNA

attL 797249:797264|attR 879248:879263

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002294466.1\|767288_767771_-\|tRNA	prolyl-tRNA editing protein	NA	NA	NA	NA
WP_002294467.1\|767920_768289_+	hypothetical protein	NA	NA	NA	NA
WP_002294470.1\|768753_769206_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_086274767.1\|769328_770180_-	sugar transporter	NA	NA	NA	NA
WP_002294471.1\|770192_770978_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_002294472.1\|771372_772314_-	riboflavin biosynthesis protein RibF	NA	NA	NA	NA
WP_002294474.1\|772317_773241_-\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_002294143.1\|776420_776642_+	hypothetical protein	NA	NA	NA	NA
WP_099746306.1\|776749_777097_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_002294141.1\|777123_779430_-	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	3.6e-19	23.7
WP_002288509.1\|779442_779754_-	YlxQ-related RNA-binding protein	NA	NA	NA	NA
WP_002288501.1\|779750_780044_-	YlxR family protein	NA	NA	NA	NA
WP_002288500.1\|780065_781241_-	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_002288499.1\|781264_781738_-	ribosome maturation factor RimP	NA	NA	NA	NA
WP_002294137.1\|786444_788154_-\|tRNA	proline--tRNA ligase	NA	NA	NA	NA
WP_002294136.1\|788221_789490_-\|protease	RIP metalloprotease RseP	NA	NA	NA	NA
WP_002294135.1\|789650_790451_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_002293875.1\|791453_792011_-	ribosome recycling factor	NA	NA	NA	NA
WP_002293877.1\|792013_792736_-	UMP kinase	NA	NA	NA	NA
WP_002293878.1\|792871_793753_-	elongation factor Ts	NA	NA	NA	NA
WP_002293880.1\|793851_794634_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_002293881.1\|794992_795472_+	ArgR family transcriptional regulator	NA	NA	NA	NA
WP_002293884.1\|796771_797557_+	phosphonoacetaldehyde hydrolase	NA	NA	NA	NA
797249:797264	attL	NA	NA	NA	NA
WP_002293885.1\|797902_799594_-\|tRNA	arginine--tRNA ligase	A0A2I2L3K1	Orpheovirus	9.9e-75	32.8
WP_002288434.1\|800015_800963_-	carbamate kinase	NA	NA	NA	NA
WP_002288437.1\|801077_802097_-	ornithine carbamoyltransferase	NA	NA	NA	NA
WP_002288439.1\|802187_803417_-	arginine deiminase	NA	NA	NA	NA
WP_002288442.1\|803876_804578_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_002293887.1\|805149_806166_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	5.4e-60	41.4
WP_002293888.1\|806162_806627_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_002293890.1\|806633_807176_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_002302614.1\|807159_807984_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_002293893.1\|808072_809053_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	5.8e-19	28.9
WP_002293895.1\|809076_810561_-	UDP-glucose--hexose-1-phosphate uridylyltransferase	NA	NA	NA	NA
WP_002293897.1\|810572_811562_-	UDP-glucose 4-epimerase GalE	A0A1V0SG19	Hokovirus	1.6e-48	36.8
WP_002288457.1\|811810_811978_+	DUF3042 family protein	NA	NA	NA	NA
WP_002293899.1\|812039_813851_-	FAD/NAD(P)-binding protein	NA	NA	NA	NA
WP_002288459.1\|813847_814213_-	DUF488 family protein	NA	NA	NA	NA
WP_002293900.1\|814375_814771_-	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_002293901.1\|814788_815751_-	ROK family glucokinase	NA	NA	NA	NA
WP_002293902.1\|815750_815963_-	YqgQ family protein	NA	NA	NA	NA
WP_099746404.1\|815983_816649_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_002289886.1\|816700_817243_-	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
WP_002293903.1\|817374_818379_-	iron ABC transporter permease	NA	NA	NA	NA
WP_002313132.1\|818375_819326_-	iron ABC transporter permease	NA	NA	NA	NA
WP_002293905.1\|819360_820167_-	ABC transporter ATP-binding protein	A0A1V0SJ29	Klosneuvirus	1.0e-13	32.1
WP_002293906.1\|820332_821289_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002296121.1\|821365_821884_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	7.1e-24	39.1
WP_002296119.1\|821971_822121_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_002293914.1\|822350_822797_+	DUF2188 domain-containing protein	NA	NA	NA	NA
WP_002293915.1\|822990_824886_-	asparagine synthase (glutamine-hydrolyzing)	F2Y2L7	Organic_Lake_phycodnavirus	6.0e-20	26.2
WP_016627840.1\|827161_827728_+	hypothetical protein	NA	NA	NA	NA
WP_099746307.1\|827759_829037_-	LysM peptidoglycan-binding domain-containing protein	A0A0S2MYF3	Enterococcus_phage	6.4e-167	68.9
WP_099746308.1\|829047_829245_-\|holin	holin	A0A0S2MYF6	Enterococcus_phage	7.8e-24	84.4
WP_002322123.1\|829260_829503_-\|holin	holin	D2J075	Enterococcus_phage	2.1e-23	68.4
WP_099746309.1\|829574_831848_-\|plate	BppU family phage baseplate upper protein	A0A249XZH9	Enterococcus_phage	4.2e-105	60.5
WP_099746310.1\|831847_833929_-	hypothetical protein	D2IYX8	Enterococcus_phage	5.2e-166	68.6
WP_099746311.1\|833944_834796_-\|tail	phage tail protein	D2IYX7	Enterococcus_phage	5.0e-83	54.9
WP_099746312.1\|834807_838707_-	tape measure protein	D2IYX6	Enterococcus_phage	1.3e-202	74.3
WP_099746313.1\|838711_838978_-	hypothetical protein	D2IYX5	Enterococcus_phage	4.3e-25	66.7
WP_099746314.1\|838995_839496_-	hypothetical protein	D2IZN3	Enterococcus_phage	3.0e-48	60.8
WP_099746315.1\|839531_840407_-	hypothetical protein	D2IYX3	Enterococcus_phage	1.6e-132	75.9
WP_099746316.1\|840416_841046_-\|tail	phage major tail protein, TP901-1 family	D2IYX2	Enterococcus_phage	4.8e-91	83.7
WP_099746317.1\|841058_841415_-	hypothetical protein	D2IYX1	Enterococcus_phage	8.8e-42	69.5
WP_099746318.1\|841419_841764_-	hypothetical protein	D2IYX0	Enterococcus_phage	2.2e-29	57.9
WP_099746319.1\|841760_842042_-	hypothetical protein	D2IYW9	Enterococcus_phage	1.1e-15	45.7
WP_099746320.1\|842041_842392_-	hypothetical protein	D2IYW8	Enterococcus_phage	1.2e-38	67.8
WP_099746321.1\|842406_843381_-\|capsid	phage capsid protein	D2IYW7	Enterococcus_phage	3.2e-150	88.5
WP_099746322.1\|843393_844020_-	DUF4355 domain-containing protein	D2IYW6	Enterococcus_phage	6.9e-50	66.3
WP_099746323.1\|844243_845143_-\|head	phage head morphogenesis protein	D2IYW4	Enterococcus_phage	6.5e-134	78.5
WP_099746324.1\|845147_846647_-\|portal	phage portal protein	D2IYW2	Enterococcus_phage	2.0e-236	81.3
WP_099746325.1\|846662_848123_-\|terminase	phage terminase large subunit	Q2QER6	Lactococcus_phage	9.9e-132	53.1
WP_099746326.1\|848109_848568_-\|terminase	terminase small subunit	E0Y3R8	Staphylococcus_virus	6.5e-05	47.7
WP_099746327.1\|848707_849616_-	hypothetical protein	C9E2Q0	Enterococcus_phage	4.0e-46	41.1
WP_099746328.1\|849785_850262_-	DUF1492 domain-containing protein	A0A2H4JFW6	uncultured_Caudovirales_phage	7.4e-28	51.6
WP_104846539.1\|850324_850570_-	hypothetical protein	NA	NA	NA	NA
WP_099746329.1\|850608_851037_+	hypothetical protein	R9VW35	Paenibacillus_phage	2.6e-08	31.2
WP_002335802.1\|851143_851335_-	hypothetical protein	NA	NA	NA	NA
WP_002301751.1\|851342_851531_-	hypothetical protein	NA	NA	NA	NA
WP_045172094.1\|851527_852103_-	hypothetical protein	NA	NA	NA	NA
WP_099746330.1\|852151_852583_+	hypothetical protein	NA	NA	NA	NA
WP_045172092.1\|852575_853052_-	DUF1064 domain-containing protein	A0A1P8BKR1	Lactococcus_phage	2.6e-17	42.3
WP_099746331.1\|853009_853198_-	hypothetical protein	NA	NA	NA	NA
WP_099746332.1\|853218_853437_-	hypothetical protein	NA	NA	NA	NA
WP_099746333.1\|853433_854282_-	ATP-binding protein	A0A2D1GQF9	Lysinibacillus_phage	3.9e-19	29.5
WP_074399786.1\|854281_855064_-	hypothetical protein	Q6J1V6	Lactobacillus_phage	5.1e-50	49.6
WP_099746334.1\|855858_856860_-	recombinase RecT	D7RWF9	Brochothrix_phage	3.1e-76	63.9
WP_099746335.1\|856860_857055_-	hypothetical protein	NA	NA	NA	NA
WP_002369161.1\|857064_857289_-	hypothetical protein	NA	NA	NA	NA
WP_099746336.1\|857288_857618_-	hypothetical protein	NA	NA	NA	NA
WP_099746337.1\|857639_857837_-	hypothetical protein	NA	NA	NA	NA
WP_002342110.1\|857849_858116_-	hypothetical protein	NA	NA	NA	NA
WP_002321800.1\|858126_858318_-	hypothetical protein	NA	NA	NA	NA
WP_099746338.1\|858609_858948_+	helix-turn-helix transcriptional regulator	A0A126GGQ7	Streptococcus_phage	2.6e-19	48.3
WP_099746339.1\|858959_859373_+	ImmA/IrrE family metallo-endopeptidase	D2IZV8	Enterococcus_phage	1.1e-11	31.4
WP_099746340.1\|859386_859587_+	hypothetical protein	A0A097BY73	Enterococcus_phage	4.6e-24	84.8
WP_099746341.1\|859667_860144_+	hypothetical protein	NA	NA	NA	NA
WP_099746342.1\|860136_860583_+	hypothetical protein	NA	NA	NA	NA
WP_099746343.1\|860954_862160_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5S7K9	Streptococcus_phage	2.8e-63	37.1
WP_002293919.1\|862443_863010_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_099746344.1\|863265_864597_+	DUF1576 domain-containing protein	NA	NA	NA	NA
WP_002293923.1\|864562_864916_+	hypothetical protein	NA	NA	NA	NA
WP_002306407.1\|865007_865427_-	cupin domain-containing protein	NA	NA	NA	NA
WP_002293927.1\|865427_865772_-	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_002287776.1\|866121_866718_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	8.7e-34	41.7
WP_002293930.1\|868917_869130_-	hypothetical protein	NA	NA	NA	NA
WP_002288573.1\|870006_870393_+	YxeA family protein	NA	NA	NA	NA
WP_002293932.1\|870436_870649_+\|integrase	integrase	A0A0P0I3D2	Lactobacillus_phage	3.5e-06	62.5
WP_002288574.1\|870753_872100_-	glucose-6-phosphate isomerase	NA	NA	NA	NA
WP_002293933.1\|872210_873560_-	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_002288577.1\|874999_875485_-\|tRNA	Cys-tRNA(Pro) deacylase	NA	NA	NA	NA
879248:879263	attR	NA	NA	NA	NA

DBSCAN-SWA_3

885578 : 943273

Paramecium_bursaria_Chlorella_virus(23.08%)

integrase,protease,transposase,tRNA

attL 922749:922769|attR 955799:955819

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000222572.1\|885578_886532_-\|transposase	IS30 family transposase	NA	NA	NA	NA
WP_000997695.1\|886925_888104_+\|transposase	IS256-like element ISEf1 family transposase	NA	NA	NA	NA
WP_099746345.1\|888142_888436_-	hypothetical protein	NA	NA	NA	NA
WP_002321266.1\|888721_888961_+	hypothetical protein	NA	NA	NA	NA
WP_002289617.1\|889322_889583_-	hypothetical protein	NA	NA	NA	NA
WP_002293950.1\|889766_890264_-	GAF domain-containing protein	NA	NA	NA	NA
WP_099746346.1\|891115_892768_-	acetolactate synthase AlsS	NA	NA	NA	NA
WP_002297646.1\|892984_893647_-	DUF624 domain-containing protein	NA	NA	NA	NA
WP_002293954.1\|893656_894526_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_002293955.1\|894536_895433_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_002293957.1\|896772_897027_-	hypothetical protein	NA	NA	NA	NA
WP_099746347.1\|897010_897169_+	transcriptional regulator	NA	NA	NA	NA
WP_002288972.1\|897176_897290_+\|protease	CAAX amino protease	NA	NA	NA	NA
WP_002293960.1\|898172_898403_+	hypothetical protein	NA	NA	NA	NA
WP_033581966.1\|898402_898708_+	hypothetical protein	NA	NA	NA	NA
WP_002295271.1\|899245_900220_-	choloylglycine hydrolase family protein	M1HVK5	Paramecium_bursaria_Chlorella_virus	5.4e-25	31.8
WP_002337288.1\|900832_901741_-\|transposase	IS982-like element ISEfm1 family transposase	NA	NA	NA	NA
WP_002333089.1\|902230_903556_-	Y-family DNA polymerase	M1Q231	Streptococcus_phage	1.0e-98	43.4
WP_002325007.1\|903851_904811_+\|transposase	IS30-like element IS6770 family transposase	NA	NA	NA	NA
WP_002295186.1\|904969_905446_-	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_002295185.1\|905458_906961_-	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_099746348.1\|906974_907637_-	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
WP_002289254.1\|907823_908642_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_002289255.1\|908871_909102_+	resolvase	NA	NA	NA	NA
WP_002295182.1\|909686_910142_-\|transposase	IS200/IS605 family transposase	A0A0H3UZM0	Geobacillus_virus	4.3e-17	38.2
WP_099746349.1\|910384_911810_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.9e-47	39.5
WP_002302077.1\|911980_912943_-	LacI family transcriptional regulator	C6ZCU4	Enterobacteria_phage	2.3e-20	25.8
WP_002293865.1\|912944_914384_-	sucrose-6-phosphate hydrolase	NA	NA	NA	NA
WP_002293868.1\|914568_916515_+	PTS beta-glucoside transporter subunit IIBCA	NA	NA	NA	NA
WP_002292418.1\|916778_917651_+	ROK family protein	NA	NA	NA	NA
WP_002286913.1\|920831_921179_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_002293717.1\|921314_922076_-\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_002293716.1\|922065_922587_-	ribosome maturation factor RimM	NA	NA	NA	NA
922749:922769	attL	NA	NA	NA	NA
WP_002325027.1\|922756_923548_-	hypothetical protein	NA	NA	NA	NA
WP_002290277.1\|923671_923923_-	KH domain-containing protein	NA	NA	NA	NA
WP_002290274.1\|923934_924210_-	30S ribosomal protein S16	NA	NA	NA	NA
WP_002293714.1\|924462_925017_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	2.3e-12	29.3
WP_002293712.1\|925095_925668_-	dihydrofolate reductase	NA	NA	NA	NA
WP_002293710.1\|925619_926198_-	DNA-3-methyladenine glycosylase I	NA	NA	NA	NA
WP_099746350.1\|926309_927638_-	signal recognition particle protein	NA	NA	NA	NA
WP_002293708.1\|927747_928086_-	putative DNA-binding protein	NA	NA	NA	NA
WP_099746351.1\|928045_928549_-	DUF523 domain-containing protein	NA	NA	NA	NA
WP_002293705.1\|928679_929384_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.4e-38	36.2
WP_002293703.1\|929380_931117_+	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	9.3e-28	34.1
WP_002293701.1\|931219_933694_-	cation-translocating P-type ATPase	M1HBF8	Paramecium_bursaria_Chlorella_virus	1.7e-46	29.2
WP_002289807.1\|934018_934909_-	phosphate ABC transporter substrate-binding protein PstS family protein	NA	NA	NA	NA
WP_002293699.1\|935105_935588_-	hypothetical protein	NA	NA	NA	NA
WP_002289810.1\|935794_936160_+	hypothetical protein	NA	NA	NA	NA
WP_002322761.1\|936250_936568_-	hypothetical protein	NA	NA	NA	NA
WP_002295271.1\|937297_938272_-	choloylglycine hydrolase family protein	M1HVK5	Paramecium_bursaria_Chlorella_virus	5.4e-25	31.8
WP_002295273.1\|938434_938692_+	hypothetical protein	NA	NA	NA	NA
WP_008266934.1\|938923_939337_-	DUF4231 domain-containing protein	NA	NA	NA	NA
WP_000997695.1\|939475_940654_-\|transposase	IS256-like element ISEf1 family transposase	NA	NA	NA	NA
WP_086956687.1\|941046_942209_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.6e-79	51.3
WP_002294831.1\|942319_943012_-	N-acetylmuramoyl-L-alanine amidase	Q9MCC6	Lactobacillus_phage	2.3e-30	43.4
WP_002294833.1\|943006_943273_+\|integrase	tyrosine-type recombinase/integrase	A0A0P0I3D2	Lactobacillus_phage	2.8e-08	58.7
955799:955819	attR	NA	NA	NA	NA

DBSCAN-SWA_4

1690344 : 1707067

Streptococcus_phage(84.62%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002319485.1\|1690344_1691634_-	PDZ domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	5.7e-22	30.2
WP_002345011.1\|1692061_1692541_+	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	NA	NA	NA	NA
WP_001825268.1\|1692751_1692871_+	hypothetical protein	NA	NA	NA	NA
WP_000420682.1\|1692893_1693208_+	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000985015.1\|1693223_1693610_+	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000813488.1\|1693638_1695024_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000398284.1\|1695202_1696408_+	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_002286940.1\|1697191_1699102_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	7.1e-37	29.8
WP_032509114.1\|1699205_1699430_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	8.5e-27	97.1
WP_002345010.1\|1699546_1700044_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.3e-88	97.6
WP_002345009.1\|1700130_1700523_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	4.6e-68	99.2
WP_000331148.1\|1700506_1702954_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	98.4
WP_002345008.1\|1702956_1705140_+	membrane protein	A0A1S5SF30	Streptococcus_phage	2.9e-305	82.3
WP_002345007.1\|1705136_1706138_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	1.3e-183	95.5
WP_074400123.1\|1706134_1707067_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	5.1e-158	91.6

DBSCAN-SWA_5

2131813 : 2205992

Enterococcus_phage(45.71%)

plate,terminase,holin,integrase,capsid,portal,tail,head,tRNA

attL 2167883:2167918|attR 2206084:2206119

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_086274861.1\|2131813_2134612_-\|tRNA	isoleucine--tRNA ligase	A0A2H4UVG0	Bodo_saltans_virus	9.6e-75	26.4
WP_002286622.1\|2134873_2135581_-	DivIVA domain-containing protein	NA	NA	NA	NA
WP_002286624.1\|2135601_2136384_-	RNA-binding protein	NA	NA	NA	NA
WP_073120020.1\|2136432_2136720_-	YggT family protein	NA	NA	NA	NA
WP_002286627.1\|2136734_2137334_-	cell division protein SepF	NA	NA	NA	NA
WP_002286628.1\|2137347_2138025_-	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_002286629.1\|2138041_2139283_-	cell division protein FtsZ	NA	NA	NA	NA
WP_002286631.1\|2139305_2140631_-	cell division protein FtsA	NA	NA	NA	NA
WP_086274863.1\|2142020_2143109_-	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	NA	NA	NA	NA
WP_002286639.1\|2144507_2145470_-	phospho-N-acetylmuramoyl-pentapeptide- transferase	NA	NA	NA	NA
WP_002286640.1\|2145495_2147688_-	penicillin-binding protein	NA	NA	NA	NA
WP_002294542.1\|2147688_2148090_-	cell division protein FtsL	NA	NA	NA	NA
WP_002286642.1\|2148094_2149054_-	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	NA	NA	NA	NA
WP_002286645.1\|2149074_2149506_-	division/cell wall cluster transcriptional repressor MraZ	NA	NA	NA	NA
WP_002286647.1\|2149675_2150044_-	DUF3397 domain-containing protein	NA	NA	NA	NA
WP_002286649.1\|2150214_2151171_+	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_002291876.1\|2151243_2151360_+	DUF4044 domain-containing protein	NA	NA	NA	NA
WP_002286651.1\|2151414_2153097_-	DNA repair protein RecN	NA	NA	NA	NA
WP_002286653.1\|2153114_2153564_-	arginine repressor	NA	NA	NA	NA
WP_002286655.1\|2153670_2154489_-	TlyA family RNA methyltransferase	NA	NA	NA	NA
WP_002286656.1\|2154497_2155388_-	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_002286657.1\|2155389_2155614_-	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_002294545.1\|2155618_2156956_-	exodeoxyribonuclease VII large subunit	L7RDW5	Acanthamoeba_polyphaga_moumouvirus	6.7e-26	29.5
WP_002286660.1\|2156956_2157811_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	6.8e-40	38.7
WP_002286662.1\|2157907_2158357_-	transcription antitermination factor NusB	NA	NA	NA	NA
WP_002286664.1\|2158349_2158775_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_002286665.1\|2159020_2160085_-	aminopeptidase P family protein	NA	NA	NA	NA
WP_002286666.1\|2160256_2160502_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_002286668.1\|2160640_2161015_-	DUF956 family protein	NA	NA	NA	NA
WP_002286670.1\|2161097_2162012_-	PTS mannose/fructose/sorbose transporter family subunit IID	NA	NA	NA	NA
WP_002294546.1\|2162032_2162836_-	PTS mannose/fructose/sorbose transporter subunit IIC	NA	NA	NA	NA
WP_002289456.1\|2162868_2163858_-	PTS mannose transporter subunit IIAB	NA	NA	NA	NA
WP_002289455.1\|2163960_2164452_-	PTS transporter subunit IIB	NA	NA	NA	NA
WP_002294024.1\|2164642_2167477_-	sigma-54-dependent transcriptional regulator	NA	NA	NA	NA
2167883:2167918	attL	NA	NA	NA	NA
WP_016631324.1\|2168129_2168774_+	SHOCT domain-containing protein	O48432	Lactobacillus_phage	5.5e-18	33.5
WP_048340730.1\|2168866_2169169_+	hypothetical protein	NA	NA	NA	NA
WP_146681469.1\|2169994_2170315_-	hypothetical protein	NA	NA	NA	NA
WP_099746399.1\|2170335_2170587_-	hypothetical protein	NA	NA	NA	NA
WP_086274867.1\|2170576_2171965_-	AAA family ATPase	V9QJ85	Oenococcus_phage	6.2e-75	37.5
WP_086274869.1\|2172140_2172719_+	hypothetical protein	NA	NA	NA	NA
WP_086274872.1\|2172778_2173753_-	N-acetylmuramoyl-L-alanine amidase	A0A060AHF9	Enterococcus_phage	2.1e-125	65.4
WP_002333628.1\|2173752_2174166_-\|holin	phage holin family protein	A0A097BY69	Enterococcus_phage	1.7e-41	65.4
WP_002333629.1\|2174227_2174356_-	XkdX family protein	NA	NA	NA	NA
WP_002333630.1\|2174357_2174804_-	hypothetical protein	NA	NA	NA	NA
WP_086274876.1\|2177010_2177769_-	hypothetical protein	A0A067XGT4	Enterococcus_phage	1.3e-26	31.4
WP_086274878.1\|2177781_2179566_-\|plate	BppU family phage baseplate upper protein	Q9AZX4	Lactococcus_phage	2.2e-40	41.8
WP_086274880.1\|2179540_2182387_-	peptidoglycan DD-metalloendopeptidase family protein	A0A1P8BMB8	Lactococcus_phage	0.0e+00	61.3
WP_086275012.1\|2182383_2183151_-\|tail	phage tail protein	D7RWD9	Brochothrix_phage	3.1e-60	45.5
WP_086274882.1\|2183183_2185208_-	tape measure protein	A0A191KBR4	Streptococcus_virus	2.5e-125	49.8
WP_002367057.1\|2185223_2185487_-	hypothetical protein	A0A1P8BKT4	Lactococcus_phage	5.5e-17	48.9
WP_010729088.1\|2185558_2185903_-	hypothetical protein	A0A1L2JXK6	Streptococcus_phage	5.7e-30	60.2
WP_025479159.1\|2186470_2186863_-	hypothetical protein	Q77K20	Lactococcus_phage	1.5e-47	73.8
WP_002318275.1\|2186862_2187201_-	HK97 gp10 family phage protein	Q77K21	Lactococcus_phage	3.0e-31	59.8
WP_086274886.1\|2187184_2187511_-	hypothetical protein	C9E2J7	Enterococcus_phage	2.1e-37	70.2
WP_002322709.1\|2187507_2187837_-	hypothetical protein	A0A0S2MYD5	Enterococcus_phage	8.4e-39	75.5
WP_086274888.1\|2187848_2188112_-	hypothetical protein	D2J062	Enterococcus_phage	5.0e-10	72.9
WP_002330281.1\|2188129_2189053_-\|capsid	phage major capsid protein	A0A1B1V000	Enterococcus_phage	2.4e-139	77.5
WP_086274890.1\|2189065_2189668_-	DUF4355 domain-containing protein	A0A097BY91	Enterococcus_phage	1.2e-35	50.7
WP_081139780.1\|2189795_2190722_-\|head	phage head morphogenesis protein	A0A1L2JXH2	Streptococcus_phage	1.3e-92	58.7
WP_086274892.1\|2190726_2192226_-\|portal	phage portal protein	A0A097BY86	Enterococcus_phage	2.5e-223	79.6
WP_086274894.1\|2192238_2193483_-\|terminase	PBSX family phage terminase large subunit	D2IYW1	Enterococcus_phage	4.3e-200	81.2
WP_002342959.1\|2193469_2194003_-\|terminase	terminase small subunit	A0A059NT97	Lactococcus_phage	9.2e-19	40.7
WP_048946664.1\|2194029_2194254_-	hypothetical protein	NA	NA	NA	NA
WP_025477932.1\|2194804_2195323_+	hypothetical protein	A0A182BQC2	Lactococcus_phage	6.6e-22	35.7
WP_002332450.1\|2195591_2196005_-	ArpU family phage transcriptional regulator	C9E2P5	Enterococcus_phage	5.6e-56	80.3
WP_086274896.1\|2196080_2196377_-	hypothetical protein	NA	NA	NA	NA
WP_002323694.1\|2196373_2196595_-	hypothetical protein	NA	NA	NA	NA
WP_086274898.1\|2196595_2196907_-	hypothetical protein	A0A0D3MVS9	Staphylococcus_phage	1.1e-27	59.0
WP_086274900.1\|2196894_2197206_-	hypothetical protein	NA	NA	NA	NA
WP_086274914.1\|2197367_2197637_-	hypothetical protein	NA	NA	NA	NA
WP_002301524.1\|2198397_2199084_-	hypothetical protein	C9E2N1	Enterococcus_phage	2.9e-89	70.0
WP_002322006.1\|2199089_2199824_-	DUF1071 domain-containing protein	A0A1X9IGE5	Lactococcus_phage	2.1e-42	48.4
WP_086274918.1\|2199816_2200158_-	hypothetical protein	NA	NA	NA	NA
WP_002301530.1\|2200480_2200669_-	hypothetical protein	D2IZW5	Enterococcus_phage	3.1e-06	56.9
WP_002343410.1\|2200689_2200974_-	hypothetical protein	NA	NA	NA	NA
WP_002330306.1\|2200951_2201164_-	helix-turn-helix transcriptional regulator	D2IZW2	Enterococcus_phage	2.6e-09	54.5
WP_086274920.1\|2201166_2201940_-	phage antirepressor	B2ZYU5	Staphylococcus_phage	5.9e-67	52.8
WP_002301534.1\|2201996_2202218_+	hypothetical protein	NA	NA	NA	NA
WP_086274922.1\|2202393_2202582_-	hypothetical protein	NA	NA	NA	NA
WP_010731229.1\|2202658_2203075_+	hypothetical protein	NA	NA	NA	NA
WP_086274924.1\|2203689_2204037_+	helix-turn-helix transcriptional regulator	A0A097QQ00	Enterococcus_phage	7.0e-28	61.6
WP_086275017.1\|2204072_2204468_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_002372718.1\|2204520_2204832_+	hypothetical protein	NA	NA	NA	NA
WP_002301539.1\|2204843_2205992_+\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	3.0e-67	40.1
2206084:2206119	attR	NA	NA	NA	NA

DBSCAN-SWA_6

2226883 : 2235355

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002288083.1\|2226883_2229073_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	1.8e-286	66.6
WP_002288081.1\|2229387_2229990_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A288TZV3	Enterococcus_phage	1.7e-53	58.6
WP_002294035.1\|2230043_2231165_-	DNA polymerase IV	NA	NA	NA	NA
WP_002288078.1\|2231273_2232146_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	3.1e-88	60.4
WP_002288076.1\|2232214_2232562_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	5.1e-18	41.1
WP_002288073.1\|2232554_2233379_-	stage 0 sporulation family protein	NA	NA	NA	NA
WP_002288071.1\|2233414_2234353_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	3.3e-35	34.4
WP_002292340.1\|2234366_2234696_-	hypothetical protein	NA	NA	NA	NA
WP_002294039.1\|2234710_2235355_-	dTMP kinase	M1PSC7	Streptococcus_phage	4.2e-58	52.6

DBSCAN-SWA_7

2650808 : 2689330

Staphylococcus_phage(30.0%)

plate,holin,tail,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002285932.1\|2650808_2650988_+\|transposase	transposase	NA	NA	NA	NA
WP_002321622.1\|2650981_2651194_+	hypothetical protein	NA	NA	NA	NA
WP_104674935.1\|2651181_2651352_+	hypothetical protein	NA	NA	NA	NA
WP_077974465.1\|2651775_2652525_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_016249808.1\|2652941_2656013_-	hypothetical protein	NA	NA	NA	NA
WP_002285922.1\|2657918_2658680_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_002285920.1\|2658779_2660501_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.7e-37	28.0
WP_002285917.1\|2662679_2664233_-	glycosyl hydrolase	NA	NA	NA	NA
WP_002285916.1\|2664580_2666995_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	72.8
WP_002301403.1\|2667421_2669440_-	LysM peptidoglycan-binding domain-containing protein	Q9ZXE4	Bacillus_phage	5.8e-13	39.6
WP_002285911.1\|2669809_2670466_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_002285909.1\|2670465_2671422_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	3.3e-43	57.4
WP_002285906.1\|2671421_2671988_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	2.2e-34	42.8
WP_049052232.1\|2672423_2672654_+	hypothetical protein	NA	NA	NA	NA
WP_002337498.1\|2672659_2672959_+	hypothetical protein	NA	NA	NA	NA
WP_002286473.1\|2672994_2673366_-	hypothetical protein	NA	NA	NA	NA
WP_002296902.1\|2673367_2673769_-	hypothetical protein	NA	NA	NA	NA
WP_002286474.1\|2673782_2674190_-	hypothetical protein	NA	NA	NA	NA
WP_087046766.1\|2675112_2676275_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	4.1e-80	54.2
WP_002286484.1\|2677214_2678240_-	N-acetylmuramoyl-L-alanine amidase	A0A139ZVY1	Enterococcus_phage	2.1e-64	61.3
WP_002286683.1\|2678236_2678461_-\|holin	holin	NA	NA	NA	NA
WP_002318262.1\|2678457_2678751_-	hypothetical protein	NA	NA	NA	NA
WP_071974452.1\|2678788_2678926_-	XkdX family protein	NA	NA	NA	NA
WP_002347165.1\|2678927_2679359_-	hypothetical protein	NA	NA	NA	NA
WP_002305897.1\|2679372_2679867_-	hypothetical protein	NA	NA	NA	NA
WP_049050272.1\|2679866_2680316_-	hypothetical protein	NA	NA	NA	NA
WP_002303306.1\|2680319_2680940_-	hypothetical protein	NA	NA	NA	NA
WP_048946725.1\|2680939_2681848_-\|plate	phage baseplate upper protein	A0A1P8BKW9	Lactococcus_phage	1.1e-08	24.3
WP_049050347.1\|2681860_2684623_-	CHAP domain-containing protein	Q9AZX5	Lactococcus_phage	1.1e-139	39.5
WP_002349898.1\|2684619_2685360_-\|tail	tail protein	NA	NA	NA	NA
WP_002349899.1\|2685349_2688139_-	tape measure protein	D7RWD8	Brochothrix_phage	5.4e-70	38.9
WP_002303297.1\|2688380_2688722_-	hypothetical protein	NA	NA	NA	NA
WP_002303295.1\|2688721_2689330_-\|tail	tail protein	NA	NA	NA	NA

DBSCAN-SWA_8

2695544 : 2712911

Enterococcus_phage(46.67%)

integrase,terminase

attL 2709863:2709876|attR 2711097:2711110

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_048946578.1\|2695544_2696960_-	DEAD/DEAH box helicase family protein	C9E2I7	Enterococcus_phage	1.4e-218	79.4
WP_048946579.1\|2696952_2697786_-\|terminase	small subunit of terminase	D2IYW0	Enterococcus_phage	4.7e-78	67.9
WP_048946580.1\|2697944_2698175_-	hypothetical protein	NA	NA	NA	NA
WP_060763461.1\|2698921_2699389_-	hypothetical protein	D7RWH7	Brochothrix_phage	2.4e-07	28.5
WP_002341971.1\|2699463_2699904_-	transcriptional regulator	D2IYV6	Enterococcus_phage	5.3e-20	38.4
WP_048946598.1\|2699933_2700227_-	hypothetical protein	NA	NA	NA	NA
WP_048946597.1\|2700257_2700452_-	hypothetical protein	NA	NA	NA	NA
WP_033646791.1\|2700557_2701010_-	hypothetical protein	NA	NA	NA	NA
WP_002318210.1\|2701035_2701497_-	class I SAM-dependent methyltransferase	A0A2H4PBJ4	Lactobacillus_phage	1.1e-60	67.1
WP_033646793.1\|2701497_2701701_-	hypothetical protein	NA	NA	NA	NA
WP_002299339.1\|2701697_2702549_-	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	2.3e-27	30.2
WP_048946585.1\|2702563_2703364_-	hypothetical protein	B4XYS6	Lactobacillus_phage	3.0e-58	54.9
WP_002301573.1\|2703406_2704297_-	hypothetical protein	D2IYT9	Enterococcus_phage	1.4e-136	84.5
WP_033646797.1\|2704298_2705240_-	endonuclease	D2IZK1	Enterococcus_phage	1.0e-145	79.2
WP_002303273.1\|2705472_2705808_-	hypothetical protein	NA	NA	NA	NA
WP_002330811.1\|2706133_2706322_-	hypothetical protein	D2IZW5	Enterococcus_phage	7.4e-08	60.3
WP_002304466.1\|2706384_2706624_+	DUF2188 domain-containing protein	E8ZD70	Streptococcus_phage	1.8e-27	81.1
WP_002299323.1\|2706620_2706776_-	hypothetical protein	NA	NA	NA	NA
WP_002297389.1\|2706915_2707128_-	hypothetical protein	NA	NA	NA	NA
WP_002297388.1\|2707130_2707343_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_002297387.1\|2707617_2708028_+	helix-turn-helix transcriptional regulator	Q5YAA4	Bacillus_phage	2.8e-31	51.4
WP_002297386.1\|2708040_2708493_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_002304713.1\|2708931_2709864_+	DUF4041 domain-containing protein	M1NRY5	Streptococcus_phage	1.8e-57	53.8
2709863:2709876	attL	NA	NA	NA	NA
WP_033647077.1\|2709935_2711057_+\|integrase	site-specific integrase	C9E2L6	Enterococcus_phage	4.0e-64	38.5
WP_049058602.1\|2711138_2712911_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.7e-54	29.5
2711097:2711110	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage