CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP025076	Streptococcus pneumoniae strain BHN97x chromosome, complete genome	3 crisprs	cas3,DEDDh,RT,DinG	0	0	11	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP025076_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025076_1

818351-818436

Orphan

Consensus_repeat	Method
CTTTTTTTGAAACGTTTCATTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025076_1

>merge|NZ_CP025076|1|818351-818436|CRISPRCasFinder
CTTTTTTTGAAACGTTTCATTTTTTTCTATAAAAGATAGCGCTTGGCGCTGTCTTTTTATTTCTTTTTTTGAAACGTTTCATTTTT

>NZ_CP025076|1|1|818351-818436|CRISPRCasFinder
CTTTTTTTGAAACGTTTCATTTTT	TTCTATAAAAGATAGCGCTTGGCGCTGTCTTTTTATTT
CTTTTTTTGAAACGTTTCATTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025076.1\|WP_000818079.1\|811221_811461_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_001084979.1\|817423_818341_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NZ_CP025076.1\|WP_001205280.1\|819855_821337_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|285470
NZ_CP025076.1\|WP_000229339.1\|824913_825684_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP025076.1\|WP_000257083.1\|809311_809782_-\|DUF3013-family-protein	unknown	unknown	gnl\|CDD\|337951
NZ_CP025076.1\|WP_000669751.1\|814877_816494_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270299
NZ_CP025076.1\|WP_000064115.1\|822814_823423_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NZ_CP025076.1\|WP_000961810.1\|810072_810525_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NZ_CP025076.1\|WP_001810816.1\|810877_811057_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_001809002.1\|821779_821944_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP025076.1\|WP_000502537.1\|813548_814868_-\|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl\|CDD\|224536
NZ_CP025076.1\|WP_000109957.1\|823453_823657_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_CP025076.1\|WP_001113214.1\|811730_813002_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP025076.1\|WP_001812322.1\|824348_824636_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP025076.1\|WP_050230303.1\|818492_819494_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP025076.1\|WP_001132287.1\|810561_810741_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_CP025076.1\|WP_000455066.1\|822605_822776_+\|DUF2273-domain-containing-protein	unknown	unknown	gnl\|CDD\|227834
NZ_CP025076.1\|WP_000797961.1\|816522_817413_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP025076.1\|WP_000782425.1\|825698_826547_-\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|335469
NZ_CP025076.1\|WP_000030213.1\|822027_822594_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	unknown	unknown	gnl\|CDD\|380217

Protein	Function_ID	Function_description	E-value
NZ_CP025076.1\|WP_000229339.1\|824913_825684_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.14768e-16
NZ_CP025076.1\|WP_001084979.1\|817423_818341_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	1.73729e-138
NZ_CP025076.1\|WP_001205280.1\|819855_821337_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|285470	pfam08270, PRD_Mga, M protein trans-acting positive regulator (MGA) PRD domain. Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This corresponds to the PRD like region.	1.09342e-73
NZ_CP025076.1\|WP_000257083.1\|809311_809782_-\|DUF3013-family-protein	gnl\|CDD\|337951	pfam11217, DUF3013, Protein of unknown function (DUF3013). This bacterial family of proteins with unknown function appear to be restricted to Firmicutes.	6.18072e-66
NZ_CP025076.1\|WP_000669751.1\|814877_816494_-\|extracellular-solute-binding-protein	gnl\|CDD\|270299	cd13581, PBP2_AlgQ_like_2, Periplasmic-binding component of alginate-specific ABC uptake system-like; contains the type 2 periplasmic binding fold. This subgroup includes uncharacterized periplasmic-binding proteins that are closely related to high molecular weight (HMW) alginate bining proteins (AlgQ1 and AlgQ2) found in gram-negative soil bacteria. The HMW alginate uptake system is composed of a novel pit formed on the cell surface and a pit-dependent ATP-binding cassette (ABC) transporter in the inner membrane. The transportation of HMW alginate from the pit to the ABC transporter is mediated by periplasmic HMW alginate-binding proteins (AlgQ1 and AlgQ2). Alginate is an anionic polysaccharide that is made up of alpha-L-mannuronate and its 5'-epimer, alpha-L-guluronate. Alginate is present in the cell walls of brown seaweeds, where it forms a viscous gum by binding water. Alginate is also produced by two bacteria genera Pseudomonas and Azotobacter. AlgQ1 and AlgQ2 belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. However, unlike other bacterial periplasmic-binding proteins that deliver small solutes to ABC transporters, AlgQ1/2 can bind a macromolecule and may have specificity for either sugar or a certain type of polysaccharide.	0
NZ_CP025076.1\|WP_000064115.1\|822814_823423_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	1.35166e-33
NZ_CP025076.1\|WP_000961810.1\|810072_810525_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	1.2282e-11
NZ_CP025076.1\|WP_001809002.1\|821779_821944_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	6.92661e-06
NZ_CP025076.1\|WP_000502537.1\|813548_814868_-\|glycoside-hydrolase-family-32-protein	gnl\|CDD\|224536	COG1621, SacC, Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism].	1.12989e-177
NZ_CP025076.1\|WP_000109957.1\|823453_823657_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	1.20386e-07
NZ_CP025076.1\|WP_001113214.1\|811730_813002_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP025076.1\|WP_001812322.1\|824348_824636_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.91273e-14
NZ_CP025076.1\|WP_050230303.1\|818492_819494_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.00843e-99
NZ_CP025076.1\|WP_001132287.1\|810561_810741_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	1.76439e-09
NZ_CP025076.1\|WP_000455066.1\|822605_822776_+\|DUF2273-domain-containing-protein	gnl\|CDD\|227834	COG5547, COG5547, Small integral membrane protein [Function unknown].	9.45975e-16
NZ_CP025076.1\|WP_000797961.1\|816522_817413_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	4.20755e-67
NZ_CP025076.1\|WP_000782425.1\|825698_826547_-\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	2.9109e-66
NZ_CP025076.1\|WP_000030213.1\|822027_822594_+\|alkaline-shock-response-membrane-anchor-protein-AmaP	gnl\|CDD\|380217	NF033218, anchor_AmaP, alkaline shock response membrane anchor protein AmaP. The founding member of this family, AmaP (Asp23 membrane anchoring protein), is related to Asp23 through part of its length, but includes a highly hydrophobic N-terminal region that should make it an integral membrane protein. Asp23 (alkaline shock protein of 23 kDa), described in PMID:7864904, is a cytosolic protein in Staphylococcus aureus, strongly induced by a pH shift from 7 to 10, and also recruited to the membrane. AmaP appears to be the partner protein with an integral membrane segment and the ability to anchor Asp23 to the membrane. This model was built to identify full-length homologs of AmaP, while excluding Asp23. Some but not all members of this family score above the cutoffs of Pfam model version PF03780.11, but full-length homologs of Asp23 score considerably higher. Asp23 family members previously were known as DUF322.	7.65552e-46

>NZ_CP025076.1|WP_001084979.1|817423_818341_-|sugar-ABC-transporter-permease
MNSKAKQVSLWERIKKQKLLLLMTVPGLVLTFIFKYIPMYGVLIAFKDYNPLKGILGSDWIGFSEFTKFISSPNFGILLANTLKLSIYGLLLGFLPPIILAIMLNQLLSEKVKKRIQLILYAPNFISVVVIVGMIFLFFSVGGPINNFLSMFGMKADFLTNPDFFRPLYIFSGIWQGMGWASTLYTATLVNVDPALVEAARLDGANIFQRIWHIDIPALKPIMVIQFVLAAGGIMNVGYEKAFLMQTSLNLPTSEIISTYVYKVGLVSGDYSYSTAVGLFNAVINVVLLVAVNQIVKRMNNGEGI
>NZ_CP025076.1|WP_000797961.1|816522_817413_-|carbohydrate-ABC-transporter-permease
MKNSIMDTKFDRRILLLNKIIIVFIVLMTLLPLLYIVVASFMDPKVLVSRGISFNPADWTVEGYQRVFSDQSILRGFINSLLYSFGFAALTVLLSVFTAYPLSKKDLVGRRWINYFLIVTMFFGGGLVPTYLLVKELGMLNTPWAIIVPGAVNVWNIILARAYFQGLPEELVEAAVIDGANDLQIFFKIMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPNLEPLQLVLRKILIQSQPGQDMIGAQAAMNEMKRLAELIKYATIVISSLPLIVMYPFFQKYFDKGIMAGSLKG
>NZ_CP025076.1|WP_000669751.1|814877_816494_-|extracellular-solute-binding-protein
MKFKTFSKSAVLLTASLAVLAACGSKNTASSPDYKLEGVTFPLQEKKTLKFMTASSPLSPKDPNEKLILQRLEKETGVHIDWTNYQSDFAEKRNLDISSGDLPDAIHNDGASDVDLMNWAKKGVIIPVENLIDKYMPNLKKILDEKPEYKALMTAPDGHIYSFPWIEELGDGKESIHSVNDMAWINKDWLKKLGLEMPKTTDDLIKVLEAFKNGDPNGNGEADEIPFSFISGNGNEDFKFLFAAFGIGDNDDHLVVGNDGKVDFTADNDNYKEGVKFIRQLQEKGLIDKEAFEHDWNSYIAKGHDQKFGVYFTWDKNNVTGSNESYDVLPVLAGPSGQKHVARTNGMGFARDKMVITSVNKNLELTAKWIDAQYAPLQSVQNNWGTYGDDKQQNIFELDQASNSLKHLPLNGTAPAELRQKTEVGGPLAILDSYYGKVTTMPDDAKWRLDLIKEYYVPYMSNDNNYPRVFMTQEDLDKIAHIEADMNDYIYRKRAEWIVNGNIDTEWDDYKKELEKYGLSDYLAIKQKYYDQYQANKN
>NZ_CP025076.1|WP_000502537.1|813548_814868_-|glycoside-hydrolase-family-32-protein
MGDKKYTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNGFVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSGSAIVKDDRLWLMYTGHIEEETGVRQVQNMAFSDDGIHFEKIEQNPVATGSDLPDELIAADFRDPKLFEKDGRYYSVVAAKHKNNVGCIVLLGSDNLVEWQFESIFLKGVEHQGFMWECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWGEKCFIPESVQEIDHGQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQFPVKKGQYQIQIDKDCHYHLGNDIDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTSRRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID
>NZ_CP025076.1|WP_001113214.1|811730_813002_+|replication-associated-recombination-protein-A
MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMILYGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHRLDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQIALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITLDIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYTARLIEAGDLPSLARRLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYVAMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKIRNHHYFQAEDTGKYERALAQRKEAIDRLRKI
>NZ_CP025076.1|WP_000818079.1|811221_811461_-|hypothetical-protein
MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFREDTPKEILDLYENIKSKLDFAYQEVYSNNGLKKYEK
>NZ_CP025076.1|WP_001810816.1|810877_811057_-|hypothetical-protein
MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDYTDDELLDKEAVFTTR
>NZ_CP025076.1|WP_001132287.1|810561_810741_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL
>NZ_CP025076.1|WP_000961810.1|810072_810525_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA
>NZ_CP025076.1|WP_000257083.1|809311_809782_-|DUF3013-family-protein
MATYGFLDILEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNAAGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNAEDYLTVIPYLPKKGFSREFLAYFALFLKDTAEVGLDTLMDFLEDPEAEEFVMEWNQEVFEEGKVGLEEGEFYPYPKY
>NZ_CP025076.1|WP_050230303.1|818492_819494_-|LacI-family-DNA-binding-transcriptional-regulator
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSDNDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGIFTINDFTALDVIEILEKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVKFVEGKTTKNENKP
>NZ_CP025076.1|WP_001205280.1|819855_821337_-|helix-turn-helix-domain-containing-protein
MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE
>NZ_CP025076.1|WP_001809002.1|821779_821944_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVITVVSFFTGRK
>NZ_CP025076.1|WP_000030213.1|822027_822594_+|alkaline-shock-response-membrane-anchor-protein-AmaP
MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNSVVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFVRSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFGIERQVKLEVAVKNYQPKPQNKKTVSRVK
>NZ_CP025076.1|WP_000455066.1|822605_822776_+|DUF2273-domain-containing-protein
MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVAAGLYIEKNYIDK
>NZ_CP025076.1|WP_000064115.1|822814_823423_+|Asp23/Gls24-family-envelope-stress-response-protein
MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLENVSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSEIREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQFEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN
>NZ_CP025076.1|WP_000109957.1|823453_823657_+|CsbD-family-protein
MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVAEDAKDAVEGAVEGVKNMLSGDDK
>NZ_CP025076.1|WP_001812322.1|824348_824636_+|IS30-family-transposase
MIVSLKTKSRKAKDMAESIQGWLAQFLVNLFKSITFDCGKEFSKWKDISNHHDSESFFANLGCPRQRCLNEHSNRLLRCHDLPKQTDFNEVSQEF
>NZ_CP025076.1|WP_000229339.1|824913_825684_-|sulfite-exporter-TauE/SafE-family-protein
MVEIIYFLIIIIASGLGSISGMGGGIIIKPLMDSFGYHSVSDIAFYSSFSVFIMAIISTTKRFSQSKEIKWRLIFTVSFSSVLGGFLGHLIFQVLLSQLSVRLVSIVQMILLFVMLLVSFVLTDFKKTYQFDKIGFYMICGLLLGLISSFLGIGGGPLNVSLLMVFFSISIKEATMYSLAIIFFSQLSHLATIVVVTGLNQYHLAPVPVIFLASICGGVLGTVVSKVLPENWVRYCFKGMLFFVMGMTLYNLFHIL
>NZ_CP025076.1|WP_000782425.1|825698_826547_-|formylglycine-generating-enzyme-family-protein
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAEREGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDTLLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEEYAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE

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Crispr_ID: NZ_CP025076_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025076_2

1390224-1390319

Orphan

Consensus_repeat	Method
AATGTGTAAGATTTTTATATATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025076_2

>merge|NZ_CP025076|2|1390224-1390319|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAATTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGAAATGTGTAAAATTTTTATATATAA

>NZ_CP025076|2|2|1390224-1390319|CRISPRCasFinder
AATGTGTAAGATTTTTATATATAA	TTTTTCTACACATACATTGTACATCTAAAAGAAAGCCCTGTCAAGAGA
AATGTGTAAAATTTTTATATATAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025076.1\|WP_000714588.1\|1381098_1382028_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226666
NZ_CP025076.1\|WP_000744893.1\|1390344_1391511_-\|CynX/NimT-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NZ_CP025076.1\|WP_000198694.1\|1389299_1389893_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NZ_CP025076.1\|WP_001189275.1\|1398083_1398404_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_001230165.1\|1398828_1399116_+\|lactococcin-972-family-bacteriocin	unknown	unknown	gnl\|CDD\|273735
NZ_CP025076.1\|WP_001030016.1\|1384969_1385956_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NZ_CP025076.1\|WP_001035700.1\|1392767_1394618_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NZ_CP025076.1\|WP_100931686.1\|1386230_1387091_+\|DUF4299-domain-containing-protein	unknown	unknown	gnl\|CDD\|339103
NZ_CP025076.1\|WP_001233696.1\|1388395_1389307_-\|DUF4097-domain-containing-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP025076.1\|WP_000724257.1\|1399167_1401276_+\|bacteriocin-associated-integral-membrane-family-protein	unknown	unknown	gnl\|CDD\|273736
NZ_CP025076.1\|WP_000808439.1\|1387268_1388333_-\|membrane-protein	unknown	unknown	gnl\|CDD\|114011
NZ_CP025076.1\|WP_000148253.1\|1380345_1380606_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_000096214.1\|1391568_1392726_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133016
NZ_CP025076.1\|WP_000838912.1\|1396545_1397217_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	unknown	unknown	gnl\|CDD\|224674
NZ_CP025076.1\|WP_000836444.1\|1397458_1398031_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NZ_CP025076.1\|WP_000800407.1\|1383222_1384698_+\|DUF3502-domain-containing-protein	unknown	unknown	gnl\|CDD\|378792
NZ_CP025076.1\|WP_000500038.1\|1395664_1396537_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	unknown	unknown	gnl\|CDD\|129801
NZ_CP025076.1\|WP_000200892.1\|1395010_1395643_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319798
NZ_CP025076.1\|WP_000273864.1\|1389879_1390206_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP025076.1\|WP_001075102.1\|1382041_1382965_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472

Protein	Function_ID	Function_description	E-value
NZ_CP025076.1\|WP_000714588.1\|1381098_1382028_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226666	COG4209, LplB, ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism].	8.41366e-143
NZ_CP025076.1\|WP_000744893.1\|1390344_1391511_-\|CynX/NimT-family-MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.66575e-125
NZ_CP025076.1\|WP_000198694.1\|1389299_1389893_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	3.23104e-64
NZ_CP025076.1\|WP_001230165.1\|1398828_1399116_+\|lactococcin-972-family-bacteriocin	gnl\|CDD\|273735	TIGR01653, hypothetical_protein, bacteriocin, lactococcin 972 family. This model represents bacteriocins related to lactococcin 972. Members tend to be found in association with a seven transmembrane putative immunity protein. [Cellular processes, Toxin production and resistance].	6.91587e-26
NZ_CP025076.1\|WP_001030016.1\|1384969_1385956_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0
NZ_CP025076.1\|WP_001035700.1\|1392767_1394618_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NZ_CP025076.1\|WP_100931686.1\|1386230_1387091_+\|DUF4299-domain-containing-protein	gnl\|CDD\|339103	pfam14132, DUF4299, Domain of unknown function (DUF4299). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	2.94462e-120
NZ_CP025076.1\|WP_001233696.1\|1388395_1389307_-\|DUF4097-domain-containing-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	9.9455e-40
NZ_CP025076.1\|WP_000724257.1\|1399167_1401276_+\|bacteriocin-associated-integral-membrane-family-protein	gnl\|CDD\|273736	TIGR01654, unnamed_protein_product, bacteriocin-associated integral membrane (putative immunity) protein. This model represents a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins (TIGR01653). Others may be associated with uncharacterized proteins that may also act as bacteriocins. Although this protein is suggested to be an immunity protein, and the bacteriocin is suggested to be exported by a Sec-dependent process, the role of this protein is unclear. [Cellular processes, Toxin production and resistance].	0
NZ_CP025076.1\|WP_000808439.1\|1387268_1388333_-\|membrane-protein	gnl\|CDD\|114011	pfam05262, Borrelia_P83, Borrelia P83/100 protein. This family consists of several Borrelia P83/P100 antigen proteins.	0.00112085
NZ_CP025076.1\|WP_000096214.1\|1391568_1392726_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	2.83355e-108
NZ_CP025076.1\|WP_000838912.1\|1396545_1397217_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta	gnl\|CDD\|224674	COG1760, SdaA, L-serine deaminase [Amino acid transport and metabolism].	1.1908e-89
NZ_CP025076.1\|WP_000836444.1\|1397458_1398031_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	5.74081e-13
NZ_CP025076.1\|WP_000800407.1\|1383222_1384698_+\|DUF3502-domain-containing-protein	gnl\|CDD\|378792	pfam12010, DUF3502, Domain of unknown function (DUF3502). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with pfam01547.	4.24398e-44
NZ_CP025076.1\|WP_000500038.1\|1395664_1396537_-\|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha	gnl\|CDD\|129801	TIGR00718, Probable_L-serine_dehydratase_alpha_chain, L-serine dehydratase, iron-sulfur-dependent, alpha subunit. This enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	2.65225e-106
NZ_CP025076.1\|WP_000200892.1\|1395010_1395643_-\|HAD-family-hydrolase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.4095e-97
NZ_CP025076.1\|WP_000273864.1\|1389879_1390206_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.12912e-19
NZ_CP025076.1\|WP_001075102.1\|1382041_1382965_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.04007e-69

>NZ_CP025076.1|WP_000273864.1|1389879_1390206_-|PadR-family-transcriptional-regulator
MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLYPILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWTLYTDTINGIIEGSIRHDKN
>NZ_CP025076.1|WP_000198694.1|1389299_1389893_-|DUF1700-domain-containing-protein
MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEELIASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILVTLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTVLAQAKSAFILIFGSGLLAIGASSLVLLGISYVTRFFGLLIVRLVQFVLKKGKRGNQHA
>NZ_CP025076.1|WP_001233696.1|1388395_1389307_-|DUF4097-domain-containing-protein
MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVYDSRTEKLTFGKEVENLEITLHQHTLTITDSFDDQIHISYHPSLSAHHDLITNQNDRTLSLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILRLPKGRTLKGINISANRGQTTIINASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAENIQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYKTEKTDVKDQLIARSDDNIDLISTPSRR
>NZ_CP025076.1|WP_000808439.1|1387268_1388333_-|membrane-protein
MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADFDTPIEKNTQLEEEVSQAEVELESQQEEKIEAPEDSEARTGIEEKKASNSTEEEPDLSKETEKVTIAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIKSPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLTLFSIVSILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIASFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIILLFFVAEVALIGDYLRILAFL
>NZ_CP025076.1|WP_100931686.1|1386230_1387091_+|DUF4299-domain-containing-protein
MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQPLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTKTDWQIIKSFLDALLAYTGTDIEGLDGFDFEAYFQASIQAYLADLVARFTICQGIFNPIFFSRENLKSFLEADGLAQFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLVDKEVQWEIDLVQITGDGSKPEDYEAIARLDYAKFLEVLPPSFYHQLDANQIEVQPILDKDFKTLAQEK
>NZ_CP025076.1|WP_001030016.1|1384969_1385956_+|rhodanese-related-sulfurtransferase
MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEEREQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV
>NZ_CP025076.1|WP_000800407.1|1383222_1384698_+|DUF3502-domain-containing-protein
MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
>NZ_CP025076.1|WP_001075102.1|1382041_1382965_+|carbohydrate-ABC-transporter-permease
MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVFVIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNVFITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVPMLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTALGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMAMVVVATLPIAILYPFFQRYFVKGLTIGGVKE
>NZ_CP025076.1|WP_000714588.1|1381098_1382028_+|sugar-ABC-transporter-permease
MKKFSKTLRDNWIFLLMVLPGTLWLILFFYIPVFGNVVAFKDYHMTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAIILSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFYADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIPQLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGMAAAAGLYQSVVGLILVILSNLLARRVDPNSALF
>NZ_CP025076.1|WP_000148253.1|1380345_1380606_+|hypothetical-protein
MTGVSNPTTDSARLVLAEAKKAFADDSLTEQGLRDILQTVKDAIASLESIKESQSATKDGGQTAGKETAGEDESANQTQEISQGIK
>NZ_CP025076.1|WP_000744893.1|1390344_1391511_-|CynX/NimT-family-MFS-transporter
MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTLFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFYTAMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL
>NZ_CP025076.1|WP_000096214.1|1391568_1392726_+|glycosyltransferase-family-2-protein
MSSKVSGFQDKNGKVLKIMIKWWKEKFRRVVVTQNVESLLVSIVISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDTEFNSIRLYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTESFVMNNVAIIQQGEFVCGGPRPTIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNEQLGRTEDNDIHYRIREYGYKIRYSPSILSYQYIRPTFKKMLHQKYLNGLWIGLTSHVQFKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGFLIVMPFLLFSIHFAYGFGTIVGLIRGFKWKKEYKRTIIYLDKISQINKNML
>NZ_CP025076.1|WP_001035700.1|1392767_1394618_+|polysaccharide-biosynthesis-protein
MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILFYGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLSYSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGAGDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIERVIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGRQEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVYHELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFKNNIRGTYNVAKAVDEAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVDNQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE
>NZ_CP025076.1|WP_000200892.1|1395010_1395643_-|HAD-family-hydrolase
MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIRGFMGPPLESSFATCLSKDQISEAVQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPLYITTTKDTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIIIGDTKFDMLGARETGIQKLAITWGFGEQADLLNYQPDYIAHKPLEVLAYFQ
>NZ_CP025076.1|WP_000500038.1|1395664_1396537_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-alpha
MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLMERNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNEHNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASISGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEVPCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLATTPTGRRLQKEIFGE
>NZ_CP025076.1|WP_000838912.1|1396545_1397217_-|L-serine-ammonia-lyase,-iron-sulfur-dependent,-subunit-beta
MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFFK
>NZ_CP025076.1|WP_000836444.1|1397458_1398031_+|LysM-peptidoglycan-binding-domain-containing-protein
MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETVSAPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY
>NZ_CP025076.1|WP_001189275.1|1398083_1398404_-|hypothetical-protein
MQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYTLLEDAKNKKSYDRLAICYVPIGICTDNAKLIQKGFSLLELTEETSMLSHLKKEVETHYQPKKL
>NZ_CP025076.1|WP_001230165.1|1398828_1399116_+|lactococcin-972-family-bacteriocin
MRKLVKIGVASLMVCGILATTNALAVWVEGGQWNYGVGWTGTFGYSDYLHSTRYHTATVRHGGRTSKDYAKPEAWARASLTKIPPTGMEYFYGFE
>NZ_CP025076.1|WP_000724257.1|1399167_1401276_+|bacteriocin-associated-integral-membrane-family-protein
MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLYLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLDFTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEMDKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQPMMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPMLWLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTALLIGVGRSLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFYQDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTGIKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFPYSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKLSDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRDIITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVLGLASRMEKRSLVELLKGGIL

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Crispr_ID: NZ_CP025076_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025076_3

1809287-1809417

Orphan

Consensus_repeat	Method
GCAAAACCTGCAGCCCCAAAAGTAAGTGCAGAAAAGAAAGCCGAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025076_3

>merge|NZ_CP025076|3|1809287-1809417|CRISPRCasFinder
GCAAAACCTGCAGCCCCAAAAGTAAGTGCAGAAAAGAAAGCCGAAAAATCTGAGCCAGCTAAACCAGCTGTAGCTAAGGAAGAGGCAAAACCTGCAGCCCCAAAAGCAAGTGCAGAAAAGAAAGCCGAAAA

>NZ_CP025076|3|3|1809287-1809417|CRISPRCasFinder
GCAAAACCTGCAGCCCCAAAAGTAAGTGCAGAAAAGAAAGCCGAAAA	ATCTGAGCCAGCTAAACCAGCTGTAGCTAAGGAAGAG
GCAAAACCTGCAGCCCCAAAAGCAAGTGCAGAAAAGAAAGCCGAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025076.1\|WP_001266083.1\|1806065_1806701_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP025076.1\|WP_000368737.1\|1814278_1814512_+\|DUF1858-domain-containing-protein	unknown	unknown	gnl\|CDD\|378108
NZ_CP025076.1\|WP_000276502.1\|1804223_1804472_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_000124543.1\|1817447_1818008_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP025076.1\|WP_000760525.1\|1803492_1804182_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP025076.1\|WP_000119707.1\|1815855_1816110_+\|DUF1912-family-protein	unknown	unknown	gnl\|CDD\|286073
NZ_CP025076.1\|WP_000840399.1\|1812866_1813646_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_000522935.1\|1813647_1813830_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_000550024.1\|1818007_1818586_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379082
NZ_CP025076.1\|WP_000857562.1\|1808507_1808801_+\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|225350
NZ_CP025076.1\|WP_001041390.1\|1808793_1809093_+\|YlxQ-related-RNA-binding-protein	unknown	unknown	gnl\|CDD\|180920
NZ_CP025076.1\|WP_001808691.1\|1806826_1807306_+\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|234627
NZ_CP025076.1\|WP_000038616.1\|1816205_1816601_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181104
NZ_CP025076.1\|WP_000752896.1\|1814511_1815846_+\|DUF438-domain-containing-protein	unknown	unknown	gnl\|CDD\|225301
NZ_CP025076.1\|WP_000032273.1\|1807349_1808486_+\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NZ_CP025076.1\|WP_000394027.1\|1804501_1805113_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP025076.1\|WP_000877381.1\|1803057_1803441_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025076.1\|WP_001273601.1\|1812236_1812587_+\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NZ_CP025076.1\|WP_000363002.1\|1805274_1806069_+\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|223584
NZ_CP025076.1\|WP_000032221.1\|1818578_1821230_+\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582

Protein	Function_ID	Function_description	E-value
NZ_CP025076.1\|WP_001266083.1\|1806065_1806701_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	2.49745e-95
NZ_CP025076.1\|WP_000368737.1\|1814278_1814512_+\|DUF1858-domain-containing-protein	gnl\|CDD\|378108	pfam08984, DUF1858, Domain of unknown function (DUF1858). This domain has no known function. It is found in various hypothetical bacterial proteins.	9.55878e-17
NZ_CP025076.1\|WP_000124543.1\|1817447_1818008_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.21026e-39
NZ_CP025076.1\|WP_000760525.1\|1803492_1804182_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.70131e-09
NZ_CP025076.1\|WP_000119707.1\|1815855_1816110_+\|DUF1912-family-protein	gnl\|CDD\|286073	pfam08930, DUF1912, Domain of unknown function (DUF1912). This domain has no known function. It is found in various Streptococcal proteins.	4.12189e-46
NZ_CP025076.1\|WP_000550024.1\|1818007_1818586_+\|AAA-family-ATPase	gnl\|CDD\|379082	pfam13238, AAA_18, AAA domain.	2.37936e-05
NZ_CP025076.1\|WP_000857562.1\|1808507_1808801_+\|YlxR-family-protein	gnl\|CDD\|225350	COG2740, COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription].	2.4995e-35
NZ_CP025076.1\|WP_001041390.1\|1808793_1809093_+\|YlxQ-related-RNA-binding-protein	gnl\|CDD\|180920	PRK07283, PRK07283, YlxQ-related RNA-binding protein.	9.95424e-60
NZ_CP025076.1\|WP_001808691.1\|1806826_1807306_+\|ribosome-maturation-factor-RimP	gnl\|CDD\|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	1.39394e-54
NZ_CP025076.1\|WP_000038616.1\|1816205_1816601_+\|hypothetical-protein	gnl\|CDD\|181104	PRK07758, PRK07758, hypothetical protein; Provisional.	0.000908369
NZ_CP025076.1\|WP_000752896.1\|1814511_1815846_+\|DUF438-domain-containing-protein	gnl\|CDD\|225301	COG2461, COG2461, Uncharacterized conserved protein [Function unknown].	5.8671e-180
NZ_CP025076.1\|WP_000032273.1\|1807349_1808486_+\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
NZ_CP025076.1\|WP_000394027.1\|1804501_1805113_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.43188e-13
NZ_CP025076.1\|WP_001273601.1\|1812236_1812587_+\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	8.02883e-49
NZ_CP025076.1\|WP_000363002.1\|1805274_1806069_+\|phosphotransferase-family-protein	gnl\|CDD\|223584	COG0510, ycfN, Thiamine kinase and related kinases [Coenzyme transport and metabolism].	9.0476e-82
NZ_CP025076.1\|WP_000032221.1\|1818578_1821230_+\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0

>NZ_CP025076.1|WP_001041390.1|1808793_1809093_+|YlxQ-related-RNA-binding-protein
MNKQKISNLLGLAQRAGRIISGEELVVKAIQDGKAKLVFLAHDAGPNLTKKIQDKSHYYQVEIVTVFSTLELSIAVGKSRKVLAVTDAGFTKKMRSLME
>NZ_CP025076.1|WP_000857562.1|1808507_1808801_+|YlxR-family-protein
MKTRKIPLRKSVVSNEVIDKRDLLRIVKNKEGQVFIDPTGKANGRGAYIKLDNAEALEAKKKKVFNRSFSMEVEESFYDELIAYVDHKVKRRELGLE
>NZ_CP025076.1|WP_000032273.1|1807349_1808486_+|transcription-termination/antitermination-protein-NusA
MSKEMLEAFRILEEDKGIKKEDIIDAVVESLRSAYRRRYGQSDSVAIDFNEKTGDFTVYTVREVVDEVFDSRLEISLKDALAINSAYELGDKIKFEEAPAEFGRVAAQSAKQTIMEKMRKQTRAITYNTYKEHEQEIMSGTVERFDNRFIYVNLGSIEAQLSKQDQIPGEVFASHDRIEVYVYKVEDNPRGVNVFVSRSHPEMIKRLMEQEIPEVYDGTVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRGGANIKKITSKFHPARYDAKNDRMVPIEENIDVIEWVADPAEFIYNAIAPAEVDQVIFDENDSKRALVVVPDNKLSLAIGRRGQNVRLAAHLTGYRIDIKSASEFEAMEDAASVELEVENDTVEE
>NZ_CP025076.1|WP_001808691.1|1806826_1807306_+|ribosome-maturation-factor-RimP
MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVDKPEGITLNDTADLTEIISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGKYIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL
>NZ_CP025076.1|WP_001266083.1|1806065_1806701_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVEVGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEVGVPNIKLLWVDGSDLTDYFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFEYSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF
>NZ_CP025076.1|WP_000363002.1|1805274_1806069_+|phosphotransferase-family-protein
MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGLAREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQLSRLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDVRHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTVLSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR
>NZ_CP025076.1|WP_000394027.1|1804501_1805113_+|CPBP-family-intramembrane-metalloprotease
MEFFDKFHALCFGFLVIIIVITVPYTINHGDFFQNESALIIVSLLVTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGAGVQHLAEVSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSNVPSFIFYLLGGLLLGFAYKKSQNLWVSTLVHMLYNSWPLLYYL
>NZ_CP025076.1|WP_000276502.1|1804223_1804472_+|hypothetical-protein
MYKHLFFLDSKTLDRLTPYILVLASDTIAFNVFVLTFVSAVVFNFLNSMLALMAIFLGAGYVVGFWLLKWFVLERLELKDDA
>NZ_CP025076.1|WP_000760525.1|1803492_1804182_+|CPBP-family-intramembrane-metalloprotease
MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNLFWIQNILSLLFIGVMIVVLVKTGHGYLFRIPRKKWLWYSILTVLVVVFQISFNVQTAKHVQSTAEGWAVLIGYSGTNFAELGIYIALFFLVPLMEELIYRGLLQHAFFKHSRFGLDLLLPSILFALPHFLSLPSLLDIFVFATVGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLTFLHRVLG
>NZ_CP025076.1|WP_000877381.1|1803057_1803441_+|hypothetical-protein
MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGVFLLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHIFIVFNALMYLLSSSQVSLKKNKLSS
>NZ_CP025076.1|WP_001273601.1|1812236_1812587_+|30S-ribosome-binding-factor-RbfA
MANHFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGDLSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEYGNKIDEMLRNLDKN
>NZ_CP025076.1|WP_000840399.1|1812866_1813646_+|hypothetical-protein
MAEQDLAMQVLQQVVKLPVVKVDRSKFLVDKFSKELGPQDIPTLLEQGPTSLLSQEILDRVANACIRDNVLLASGTSVLAGLPGGLAMAITIPADVAQFYAFSLKLAQELGYIYGYEDLWASRDELSEDAQNTLLLYLGVMLGVNGIAALLRAGGITIAKQVMKTVPNKALTKTLWYPILKKVLRIFGVNLTKGGLAKGMGKFIPILGGIISGGLTFATMKPMGESLQKELSKLVNYSEVQYQEDVETIRKEAEIIEGE
>NZ_CP025076.1|WP_000522935.1|1813647_1813830_+|hypothetical-protein
MGLIKTLAKIYGNYFLTVQGVKVMKTIKKADHVVVGLGKLFIADKLMDTARWLIKPEERE
>NZ_CP025076.1|WP_000368737.1|1814278_1814512_+|DUF1858-domain-containing-protein
MDNIIDVSIPVAEVVDKHPEVLEILVELGFKPLANPLMRNTVGRKVSLKQGSKLAGTPMDKIVRTLEANGYEVIGLD
>NZ_CP025076.1|WP_000752896.1|1814511_1815846_+|DUF438-domain-containing-protein
MADERIHVLRDILLELHNGASPESVQERFDATFAGVSAIEISLMEHELMNSDSGVTFEDVMELCDVHANLFKNAIKGVEVSDTEHPGHPVRVFKEENLALRAALIRIRRLLDTYEYMEDEEMLAEMRKGLVRQMGLVGQFDIHYQRKEELFFPIMERYGHDSPPKVMWGVDDQIRELFQTALTTAKSLPEVSISSVKEAFEAFATEFESMIFKEESILLMILLESFTQDDWLQIAEESDAYGYAIIRPSEKWVPERQSFIEEKIAEEPVQLDTAEGQVQQVIDTPEGHFTITFTPKEKEAVLDRHSQQAFGNGYLSVEQANLILNHLPMEITFVNKDDIFQYYNDNTPADEMIFKRTPSQVGRNVELCHPPKYLDKVKTIMKGLREGSKDKYEMWFKSESRGKFVHITYAAVHDEDGEFQGVLEYVQDIQPYREIDTDYFRGLE
>NZ_CP025076.1|WP_000119707.1|1815855_1816110_+|DUF1912-family-protein
MSYEQEFMKEFEAWVNTQIMINDMAHKESQKVYEEDQDERAKDAMIRYESRLDAYQFLLGKFENFKAGKGFHDLPEGLFGERNY
>NZ_CP025076.1|WP_000038616.1|1816205_1816601_+|hypothetical-protein
MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQPASAAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFKNWTEKELLALKGIGPATIKKLKENGIKFK
>NZ_CP025076.1|WP_000124543.1|1817447_1818008_+|GNAT-family-N-acetyltransferase
MARTELPDKIETERLVLRVRTVADAEDIFDYASLPEVAYPAGFPPVKTLEDEIYYLEHIFPERNQKENLPAGYGIVVKGTDKIVGSVDFNHRHEDDVLEIGYTLHPDYWGRGYVPEAARALIDLAFKDLGLHKIELTCFGYNLQSKRVAEKLDFTLEARIRDRKDAQGNCCDDLRYALLKSEWEVI
>NZ_CP025076.1|WP_000550024.1|1818007_1818586_+|AAA-family-ATPase
MHLFIIGAPASGKMTIGQELSRLTDATLFYNHQAIDFALEIYQDYTEEMWEFVRGITFSFLGASARNQRSVILTDVIDFSNQYHLIYLKQIQSLLDDYHQEILFVELETSLEECIRRNRTENRLKYKPLKRHIEVSEREIIETAETLQLNSQYQPNELHHYFKINNTNLSAEEAAKQIQNKINKIEKGHTHV
>NZ_CP025076.1|WP_000032221.1|1818578_1821230_+|valine--tRNA-ligase
MSKELSSKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEGISRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVFVDLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPEFGTGVVKITPAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVIAKLEEIGALVKIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDTFLQWMENVHDWVISRQLWWGHQIPAWYNADGEMYVGEEAPEGDGWTQDEDVLDTWFSSALWPFSTMGWPEVDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVLIHGLIRDEQGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNISRYILMNNGGLTLDVAHDNVTKVATGEAGNVTDRWILHNLNETIAKVTENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEDDKVITRSVLLYTLDKILRLLHSIMPFVTEEIFGQYAEGSIVTAAYPTVNPAFEDLAAHTGVESLKDLIRAVRNARAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSSVITGAEIFLPLVDLLNVEEELARLEKELAKWQKELDMVGKKLSNERFVANAKPEVVQKEKDKQADYQAKYDVTVVRIDEMKKLVK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

6000 : 60564

Streptococcus_phage(47.06%)

integrase,protease,tRNA,transposase,bacteriocin

attL 2354:2398|attR 53615:53659

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2354:2398	attL	NA	NA	NA	NA
WP_032495994.1\|6000_6969_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4JAA2	uncultured_Caudovirales_phage	1.4e-33	29.6
WP_000466653.1\|6991_7573_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_000526317.1\|7602_10953_+	DEAD/DEAH box helicase family protein	A0A2H4P9W3	Gordonia_phage	2.4e-11	24.8
WP_001042998.1\|11541_12012_-	arginine repressor	NA	NA	NA	NA
WP_054363793.1\|12028_14302_-	Xaa-Pro dipeptidyl-peptidase	NA	NA	NA	NA
WP_054363794.1\|14647_17749_+	DNA polymerase III subunit alpha	A0A291AWR1	Streptomyces_phage	1.5e-113	32.6
WP_000820852.1\|17831_18839_+	6-phosphofructokinase	NA	NA	NA	NA
WP_001042808.1\|18897_20403_+	pyruvate kinase	NA	NA	NA	NA
WP_000536835.1\|21474_21729_-	phage repressor protein	B3GVX0	Streptococcus_phage	3.3e-19	61.2
WP_000749604.1\|22164_23037_+	DUF4300 family protein	NA	NA	NA	NA
WP_000420569.1\|23669_23981_+	hypothetical protein	NA	NA	NA	NA
WP_000759777.1\|23984_24701_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000617836.1\|24829_25645_-	TIGR03943 family protein	NA	NA	NA	NA
WP_000123613.1\|25641_26547_-	permease	NA	NA	NA	NA
WP_000359141.1\|27003_29133_+	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_000778592.1\|29119_29569_+	SprT family protein	NA	NA	NA	NA
WP_001085044.1\|29627_29900_+	PspC domain-containing protein	NA	NA	NA	NA
WP_000680766.1\|30253_30445_-	hypothetical protein	NA	NA	NA	NA
WP_000173358.1\|30872_31631_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.7e-27	36.3
WP_100931657.1\|31632_33621_+	ABC transporter permease	NA	NA	NA	NA
WP_162828736.1\|33662_34307_-	VIT family protein	NA	NA	NA	NA
WP_001153866.1\|34332_35328_-\|transposase	IS30 family transposase	H7BVY4	unidentified_phage	2.4e-36	36.0
WP_000661000.1\|36034_37510_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_001837031.1\|37475_38192_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_000366713.1\|38447_39308_+	polyamine aminopropyltransferase	NA	NA	NA	NA
WP_000088777.1\|39304_40564_+	saccharopine dehydrogenase family protein	NA	NA	NA	NA
WP_000764350.1\|40563_41691_+	carboxynorspermidine decarboxylase	NA	NA	NA	NA
WP_000969445.1\|41687_42773_+	agmatine deiminase	M1HES8	Acanthocystis_turfacea_Chlorella_virus	1.6e-89	47.5
WP_001246755.1\|42782_43658_+	N-carbamoylputrescine amidase	M1H5W0	Paramecium_bursaria_Chlorella_virus	1.1e-77	50.0
WP_000593564.1\|43838_44648_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_000602452.1\|44919_45141_+\|bacteriocin	SP_0924 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000745370.1\|45194_45866_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001025704.1\|46107_47016_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	3.1e-06	27.7
WP_000745389.1\|47012_47474_+	signal peptidase II	NA	NA	NA	NA
WP_000403193.1\|47463_48351_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000728269.1\|48353_50237_+	MBL fold metallo-hydrolase	Q332B9	Clostridium_botulinum_C_phage	1.2e-09	22.9
WP_001844793.1\|50316_51447_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.1e-114	58.4
WP_000254675.1\|51456_52719_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.5e-139	64.5
WP_000689710.1\|52722_53520_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.2e-59	50.9
WP_000033390.1\|53739_54378_+	dTMP kinase	M1PSC7	Streptococcus_phage	6.4e-75	67.6
53615:53659	attR	NA	NA	NA	NA
WP_000806714.1\|54374_55265_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.9e-73	51.7
WP_000358228.1\|55304_55622_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.9e-28	60.0
WP_001166880.1\|55624_56494_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.7e-116	76.1
WP_001261452.1\|56720_57239_+	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_100931658.1\|57982_58787_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_001809096.1\|58763_59036_+	hypothetical protein	NA	NA	NA	NA
WP_000083696.1\|59229_60564_+\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA

DBSCAN-SWA_2

366488 : 430158

Bacillus_phage(28.57%)

holin,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_054363775.1\|366488_367442_+\|transposase	IS30-like element ISSpn8 family transposase	H7BWC8	unidentified_phage	2.1e-34	35.2
WP_000705304.1\|367761_368610_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.2e-34	39.5
WP_000643970.1\|368705_369395_-	NTP transferase domain-containing protein	A0A127AW70	Bacillus_phage	3.4e-05	45.0
WP_000837609.1\|369406_370285_-	DMT family transporter	NA	NA	NA	NA
WP_000411210.1\|370274_371144_-	phosphotransferase family protein	NA	NA	NA	NA
WP_000609894.1\|371160_372183_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_000638527.1\|372187_372895_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_000835899.1\|373230_374718_+	type IV teichoic acid flippase TacF	NA	NA	NA	NA
WP_000811874.1\|374727_375531_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	5.3e-10	27.1
WP_001199652.1\|375532_376342_+\|holin	phosphorylcholine transferase LicD	A0A1V0SD50	Indivirus	9.1e-10	30.3
WP_001126409.1\|376616_379793_-	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_000166701.1\|380105_381185_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	6.3e-59	35.9
WP_001293845.1\|381234_382158_-	aspartate carbamoyltransferase catalytic subunit	M1HGA5	Paramecium_bursaria_Chlorella_virus	8.7e-25	31.7
WP_000850024.1\|382176_382698_-	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_000244451.1\|382908_383538_-	endonuclease III	NA	NA	NA	NA
WP_000773226.1\|383537_384080_-	DUF177 domain-containing protein	NA	NA	NA	NA
WP_000389597.1\|384249_384567_+	hypothetical protein	NA	NA	NA	NA
WP_001812708.1\|384805_386365_+	ABC-F family ATP-binding cassette domain-containing protein	A0A1B0RXA0	Streptococcus_phage	9.3e-11	27.5
WP_000895736.1\|386513_387413_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_000219823.1\|387414_387975_-	LemA family protein	NA	NA	NA	NA
WP_000801941.1\|388068_388782_+	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
WP_000808288.1\|389231_390515_+	uracil transporter	Q9KX94	Enterobacteria_phage	4.0e-60	35.3
WP_000863651.1\|390709_392281_-	signal recognition particle protein	NA	NA	NA	NA
WP_000402071.1\|392292_392625_-	putative DNA-binding protein	NA	NA	NA	NA
WP_001246397.1\|392715_393081_-	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_001003498.1\|393164_394469_+	HD domain-containing protein	E3T4P8	Cafeteria_roenbergensis_virus	1.7e-26	30.2
WP_000023503.1\|394481_395288_+	sugar-phosphatase	NA	NA	NA	NA
WP_000002875.1\|395498_397274_-	DUF4365 domain-containing protein	NA	NA	NA	NA
WP_000868700.1\|397759_398941_-	N-acetylmuramoyl-L-alanine amidase family protein	NA	NA	NA	NA
WP_000722391.1\|398953_400174_-	caspase family protein	NA	NA	NA	NA
WP_000427010.1\|400267_401122_+	Rgg/GadR/MutR family transcriptional regulator	NA	NA	NA	NA
WP_001812200.1\|401353_401521_-	hypothetical protein	NA	NA	NA	NA
WP_001068669.1\|401801_402149_-	50S ribosomal protein L19	NA	NA	NA	NA
WP_000237416.1\|402267_402597_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.3e-10	37.8
WP_000712097.1\|402590_402965_-	fluoride efflux transporter CrcB	NA	NA	NA	NA
WP_000362434.1\|402961_403228_-	chorismate mutase	NA	NA	NA	NA
WP_001162129.1\|403343_403787_-	flavodoxin	NA	NA	NA	NA
WP_000401770.1\|403890_404826_+	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_001808393.1\|404879_405164_+	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_000028149.1\|405220_405439_-	hypothetical protein	NA	NA	NA	NA
WP_000199556.1\|407015_408362_+	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_000711939.1\|408857_409028_-	hypothetical protein	NA	NA	NA	NA
WP_161801419.1\|409040_409610_-	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	9.5e-14	38.5
WP_000424224.1\|411629_412079_-	YhcH/YjgK/YiaL family protein	NA	NA	NA	NA
WP_001000318.1\|412583_413039_-	HIT domain-containing protein	NA	NA	NA	NA
WP_000272437.1\|413060_414521_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000239905.1\|414583_416161_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_001180442.1\|416229_417669_-	hypothetical protein	NA	NA	NA	NA
WP_000577773.1\|417682_418612_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_001071050.1\|418622_419555_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_000448317.1\|419555_420242_-	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
WP_078063964.1\|420958_421717_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_001165927.1\|421894_422503_+	DUF624 domain-containing protein	NA	NA	NA	NA
WP_088778796.1\|422737_424089_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	5.9e-62	50.9
WP_000807140.1\|424383_424521_-	hypothetical protein	NA	NA	NA	NA
WP_000945307.1\|424654_425974_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_000356590.1\|425976_426717_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.0e-09	30.8
WP_001058021.1\|427538_428942_-	phosphotransferase	NA	NA	NA	NA
WP_000821289.1\|429570_430158_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

516398 : 522176

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001272941.1\|516398_517010_+	peptide deformylase	E3SLL2	Synechococcus_phage	4.9e-16	42.4
WP_044792798.1\|517054_517783_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000272318.1\|517821_518733_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	3.8e-89	51.1
WP_000926599.1\|518798_519023_-	DUF4059 family protein	NA	NA	NA	NA
WP_000590970.1\|519100_519844_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-29	40.5
WP_001103449.1\|519843_520644_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000889095.1\|520801_521158_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	2.0e-33	57.3
WP_001170343.1\|521151_521682_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.4e-46	54.3
WP_000405832.1\|521681_522176_-	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	1.9e-42	52.1

DBSCAN-SWA_4

615920 : 622674

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000081003.1\|615920_616889_+	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	2.8e-66	100.0
WP_000011310.1\|616922_617834_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	9.8e-154	99.3
WP_001231105.1\|617830_618808_-	YvcK family protein	A1IMD5	Streptococcus_phage	4.4e-184	99.7
WP_000163033.1\|618804_619695_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.9e-06	29.8
WP_001140412.1\|619746_620127_-	RidA family protein	NA	NA	NA	NA
WP_000422599.1\|620137_620725_-	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_000106346.1\|620733_621966_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.2e-131	59.0
WP_000442275.1\|621997_622168_-	hypothetical protein	NA	NA	NA	NA
WP_000162484.1\|622167_622674_-	dihydrofolate reductase	G3MBI7	Bacillus_virus	6.7e-27	42.5

DBSCAN-SWA_5

886751 : 894083

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000167845.1\|886751_887453_+	UDP-glucose 4-epimerase	A0A2K9L1R4	Tupanvirus	1.7e-33	35.1
WP_000777248.1\|887875_888835_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.0e-57	40.8
WP_001193658.1\|888824_889781_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_000764303.1\|889777_890530_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.6e-14	28.1
WP_000858241.1\|890625_891591_+	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000821640.1\|891815_892058_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	1.3e-17	59.4
WP_001222228.1\|892057_892780_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_000105310.1\|892766_893336_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	5.0e-15	34.9
WP_000351907.1\|893354_894083_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	5.3e-09	22.3

DBSCAN-SWA_6

1172782 : 1251451

Klosneuvirus(12.5%)

holin,tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000753884.1\|1172782_1174768_-\|holin	choline-binding protein PcpA	NA	NA	NA	NA
WP_001812165.1\|1175102_1175285_+	ATP-binding protein	NA	NA	NA	NA
WP_088795594.1\|1175229_1176078_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_076742467.1\|1176150_1176513_-	hypothetical protein	NA	NA	NA	NA
WP_000251325.1\|1176890_1178771_-	beta-N-acetylhexosaminidase	NA	NA	NA	NA
WP_000150719.1\|1178764_1179634_-	ROK family protein	NA	NA	NA	NA
WP_000432779.1\|1179717_1182363_-	alpha-mannosidase	NA	NA	NA	NA
WP_000640528.1\|1182453_1183734_-	glycoside hydrolase family 125 protein	NA	NA	NA	NA
WP_000803398.1\|1183904_1185989_+	glycoside hydrolase family 92 protein	NA	NA	NA	NA
WP_000721458.1\|1186028_1187708_-	alpha-L-fucosidase	NA	NA	NA	NA
WP_000094616.1\|1188462_1189692_+	arginine deiminase	NA	NA	NA	NA
WP_000185363.1\|1189749_1190766_+	ornithine carbamoyltransferase	NA	NA	NA	NA
WP_000013418.1\|1190930_1191878_+	carbamate kinase	NA	NA	NA	NA
WP_001290378.1\|1192088_1193600_+	YfcC family protein	NA	NA	NA	NA
WP_000686962.1\|1193621_1194953_+	Sapep family Mn(2+)-dependent dipeptidase	NA	NA	NA	NA
WP_000657757.1\|1195618_1195870_-	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_001808444.1\|1196268_1197153_-	SPFH domain-containing protein	A0A1V0SL90	Klosneuvirus	6.8e-35	32.5
WP_000190398.1\|1197297_1198449_-	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_000614264.1\|1198594_1200361_-	L-fucose isomerase	NA	NA	NA	NA
WP_001031113.1\|1200417_1203534_-	discoidin domain-containing protein	NA	NA	NA	NA
WP_000780609.1\|1203543_1205838_-	glycoside hydrolase family 95 protein	NA	NA	NA	NA
WP_000981721.1\|1205896_1206697_-	PTS mannose/fructose/sorbose transporter family subunit IID	NA	NA	NA	NA
WP_000899623.1\|1206693_1207467_-	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	NA	NA	NA	NA
WP_000020990.1\|1207491_1207962_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_000483180.1\|1207952_1208384_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_000912115.1\|1208376_1208817_-	fucose isomerase	NA	NA	NA	NA
WP_001286140.1\|1208828_1209467_-	L-fuculose-phosphate aldolase	NA	NA	NA	NA
WP_000388564.1\|1209581_1210985_-	rhamnulokinase	NA	NA	NA	NA
WP_000588550.1\|1211160_1211934_+	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_000724073.1\|1213102_1214608_-	zinc ABC transporter substrate-binding lipoprotein AdcA	NA	NA	NA	NA
WP_000950018.1\|1214617_1215424_-	metal ABC transporter permease	NA	NA	NA	NA
WP_001269488.1\|1215416_1216121_-	metal ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.7e-08	26.8
WP_001249319.1\|1216120_1216561_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000919865.1\|1216715_1217984_-	D-alanyl-lipoteichoic acid biosynthesis protein DltD	NA	NA	NA	NA
WP_000351967.1\|1217976_1218216_-	D-alanine--poly(phosphoribitol) ligase subunit DltC	NA	NA	NA	NA
WP_000969737.1\|1218229_1219474_-	D-alanyl-lipoteichoic acid biosynthesis protein DltB	A0A125RNP0	Pseudomonas_phage	3.2e-22	29.4
WP_000066737.1\|1219470_1221021_-	D-alanine--poly(phosphoribitol) ligase subunit DltA	A0A2K9KZV5	Tupanvirus	1.8e-38	28.2
WP_000813667.1\|1221041_1221173_-	teichoic acid D-Ala incorporation-associated protein DltX	NA	NA	NA	NA
WP_000071459.1\|1221493_1222672_-	MFS transporter	NA	NA	NA	NA
WP_001844696.1\|1225470_1226079_+	hypothetical protein	NA	NA	NA	NA
WP_001127309.1\|1226165_1226369_-	hypothetical protein	NA	NA	NA	NA
WP_000980819.1\|1226559_1227264_-	aquaporin family protein	M1IAZ4	Acanthocystis_turfacea_Chlorella_virus	9.3e-27	33.5
WP_000395959.1\|1227333_1229160_-	type 1 glycerol-3-phosphate oxidase	NA	NA	NA	NA
WP_000076776.1\|1229201_1230710_-	glycerol kinase GlpK	NA	NA	NA	NA
WP_000280547.1\|1230868_1232296_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000357847.1\|1232460_1233333_+	Hsp33 family molecular chaperone HslO	NA	NA	NA	NA
WP_000183312.1\|1233319_1234300_+\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_100931681.1\|1234518_1236960_-	pneumococcal surface protein PspC, LPXTG-anchored form	NA	NA	NA	NA
WP_000436492.1\|1237162_1238419_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	3.5e-226	93.8
WP_100931682.1\|1238621_1240742_-\|holin	pneumococcal surface protein PspC, choline-binding form	NA	NA	NA	NA
WP_000241935.1\|1240820_1241348_-	isoprenylcysteine carboxyl methyltransferase family protein	NA	NA	NA	NA
WP_000594665.1\|1241430_1242762_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_001024077.1\|1242758_1243412_-	response regulator transcription factor	NA	NA	NA	NA
WP_001109675.1\|1244053_1246486_-\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A223W0B1	Agrobacterium_phage	5.0e-128	40.6
WP_001211273.1\|1246487_1246946_-	CtsR family transcriptional regulator	NA	NA	NA	NA
WP_000136224.1\|1247064_1247793_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.0e-28	36.2
WP_000754546.1\|1247792_1248800_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001813866.1\|1248838_1249597_-	ABC transporter permease	NA	NA	NA	NA
WP_000647691.1\|1249559_1249850_-	thiamine-binding protein	NA	NA	NA	NA
WP_000698566.1\|1250104_1251451_-\|holin	choline binding-anchored murein hydrolase CbpD	NA	NA	NA	NA

DBSCAN-SWA_7

1260439 : 1322758

Streptococcus_phage(17.65%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000646886.1\|1260439_1260838_-\|transposase	transposase	NA	NA	NA	NA
WP_000808064.1\|1261846_1262887_-	elongation factor Ts	NA	NA	NA	NA
WP_000268465.1\|1262965_1263745_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_000727012.1\|1263968_1265147_-	CHAP domain-containing protein	NA	NA	NA	NA
WP_001249454.1\|1265240_1265735_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_001078983.1\|1265734_1266553_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_000377893.1\|1266611_1267406_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000510410.1\|1267398_1268238_-	energy-coupling factor transporter ATPase	W8CYL7	Bacillus_phage	5.2e-16	32.6
WP_000835715.1\|1268222_1269050_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	2.8e-22	32.9
WP_000712132.1\|1269046_1269592_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_001227958.1\|1269602_1270424_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_000170202.1\|1270465_1271749_-	insulinase family protein	A0A0G2Y5U8	Acanthamoeba_polyphaga_mimivirus	1.6e-16	31.0
WP_000424265.1\|1271745_1272996_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	1.0e-92	42.1
WP_000455899.1\|1273154_1273523_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	5.4e-18	58.7
WP_000266658.1\|1273525_1274623_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000073428.1\|1274673_1276152_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.2e-94	40.5
WP_000165444.1\|1276303_1277329_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000958770.1\|1277534_1279157_+	ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	3.4e-48	26.2
WP_000834685.1\|1279218_1281762_+	YfhO family protein	NA	NA	NA	NA
WP_157807009.1\|1281862_1282648_-	hypothetical protein	NA	NA	NA	NA
WP_000445498.1\|1282669_1283539_-	ABC transporter permease	NA	NA	NA	NA
WP_000649625.1\|1283905_1285159_+\|transposase	IS110 family transposase	M1NSC9	Streptococcus_phage	5.3e-150	80.8
WP_001158266.1\|1285418_1285961_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_001812112.1\|1286321_1287719_+\|transposase	ISNCY-like element IS1202 family transposase	NA	NA	NA	NA
WP_000866075.1\|1287978_1288731_-	response regulator transcription factor	NA	NA	NA	NA
WP_025169508.1\|1288727_1290053_-	sensor histidine kinase	NA	NA	NA	NA
WP_061649796.1\|1290065_1290197_-	competence-stimulating peptide ComC	NA	NA	NA	NA
WP_000695929.1\|1290478_1290958_-	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	NA	NA	NA	NA
WP_000681598.1\|1291140_1292322_+\|protease	serine protease	A0A1B1IT49	uncultured_Mediterranean_phage	1.5e-16	26.1
WP_000410381.1\|1292379_1293138_+	ParB/RepB/Spo0J family partition protein	S5VSZ7	Leptospira_phage	1.6e-16	36.1
WP_000660615.1\|1293350_1294712_+	chromosomal replication initiator protein DnaA	NA	NA	NA	NA
WP_000581147.1\|1294870_1296007_+	DNA polymerase III subunit beta	A0A0A8IL17	Aurantimonas_phage	2.0e-23	24.1
WP_000285191.1\|1296071_1296266_+	DUF951 family protein	NA	NA	NA	NA
WP_001218707.1\|1296349_1297465_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_000163928.1\|1297535_1298105_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_000258130.1\|1298105_1301615_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_001234978.1\|1301672_1301939_+	RNA-binding S4 domain-containing protein	NA	NA	NA	NA
WP_000041909.1\|1301931_1302300_+	septum formation initiator family protein	NA	NA	NA	NA
WP_001224760.1\|1302419_1303688_+	serine hydrolase	NA	NA	NA	NA
WP_001209049.1\|1303684_1304962_+\|tRNA	tRNA lysidine(34) synthetase TilS	A7K9Y8	Acanthocystis_turfacea_chlorella_virus	6.7e-07	24.6
WP_000892185.1\|1304965_1305508_+	hypoxanthine phosphoribosyltransferase	A0A218MMB5	uncultured_virus	4.7e-10	28.9
WP_000744551.1\|1305523_1307482_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	H8ZJI5	Ostreococcus_tauri_virus	2.4e-109	45.8
WP_000588911.1\|1307603_1308083_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_100931702.1\|1313575_1314421_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_000939546.1\|1315533_1315770_+	hypothetical protein	NA	NA	NA	NA
WP_000205044.1\|1316000_1317287_+	adenylosuccinate synthase	L7Y4J5	Megavirus	2.7e-72	37.1
WP_000291875.1\|1317487_1317955_+	nucleoside deaminase	NA	NA	NA	NA
WP_000701992.1\|1318140_1318584_+	dUTP diphosphatase	Q2WG49	Clostridium_botulinum_D_phage	2.1e-29	47.3
WP_001836031.1\|1318585_1319101_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_073176637.1\|1319114_1320476_+	DNA repair protein RadA	NA	NA	NA	NA
WP_001809263.1\|1320548_1321046_+	carbonic anhydrase	NA	NA	NA	NA
WP_000272771.1\|1321066_1321411_+	hypothetical protein	NA	NA	NA	NA
WP_100931684.1\|1321407_1322758_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	5.9e-62	50.9

DBSCAN-SWA_8

1335463 : 1346956

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000668270.1\|1335463_1337617_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	1.0e-44	28.0
WP_000801615.1\|1337629_1338979_+	HlyD family secretion protein	NA	NA	NA	NA
WP_000043301.1\|1339148_1339856_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	1.8e-41	39.2
WP_000361198.1\|1339912_1343638_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	2.1e-37	25.8
WP_000220639.1\|1343730_1345173_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-53	34.9
WP_001284590.1\|1345391_1346414_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	2.1e-64	43.9
WP_000717506.1\|1346410_1346956_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.4e-24	35.0

DBSCAN-SWA_9

1398828 : 1423639

Planktothrix_phage(50.0%)

bacteriocin,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001230165.1\|1398828_1399116_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000724257.1\|1399167_1401276_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000571330.1\|1401272_1401914_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-23	34.8
WP_001038474.1\|1402128_1402935_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_099516442.1\|1402900_1403371_+	argininosuccinate synthase	NA	NA	NA	NA
WP_001268157.1\|1403659_1404523_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000915346.1\|1404988_1405327_+	peptidase C39	NA	NA	NA	NA
WP_000424429.1\|1405304_1405676_+\|bacteriocin	SPH_0218 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000989850.1\|1405683_1405896_+	hypothetical protein	NA	NA	NA	NA
WP_000513492.1\|1406375_1406621_+	hypothetical protein	NA	NA	NA	NA
WP_001812063.1\|1406777_1407836_+	hypothetical protein	NA	NA	NA	NA
WP_000792249.1\|1408149_1409127_+	hypothetical protein	NA	NA	NA	NA
WP_000424417.1\|1409503_1409878_+\|bacteriocin	SPH_0224 family bacteriocin-like peptide	NA	NA	NA	NA
WP_000511668.1\|1409884_1410067_+	hypothetical protein	NA	NA	NA	NA
WP_000619744.1\|1410085_1410988_+	hypothetical protein	NA	NA	NA	NA
WP_000424449.1\|1411043_1411397_+	hypothetical protein	NA	NA	NA	NA
WP_001812064.1\|1411393_1412122_+	hypothetical protein	NA	NA	NA	NA
WP_000770314.1\|1413257_1413497_+	hypothetical protein	M1Q0Z8	Streptococcus_phage	7.2e-16	54.1
WP_054380318.1\|1414047_1416147_+	pneumococcal surface protein A	NA	NA	NA	NA
WP_001282989.1\|1416547_1417669_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_000193627.1\|1417809_1418265_+	NUDIX hydrolase	NA	NA	NA	NA
WP_000220949.1\|1418274_1420188_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	NA	NA	NA	NA
WP_000331980.1\|1420567_1422247_-	ribonuclease J	NA	NA	NA	NA
WP_000639577.1\|1422248_1422482_-	DNA-dependent RNA polymerase auxiliary subunit epsilon family protein	NA	NA	NA	NA
WP_000974047.1\|1423299_1423452_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibB	NA	NA	NA	NA
WP_000180806.1\|1423453_1423639_-\|bacteriocin	fratricide two-peptide bacteriocin subunit CibA	NA	NA	NA	NA

DBSCAN-SWA_10

1621785 : 1665559

Streptococcus_phage(23.08%)

holin,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001063394.1\|1621785_1623891_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	5.8e-117	37.6
WP_000032550.1\|1624291_1624774_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_000743624.1\|1624868_1626353_-	DUF1846 domain-containing protein	NA	NA	NA	NA
WP_001156836.1\|1626505_1628113_+	alpha-glucosidase	NA	NA	NA	NA
WP_001022228.1\|1628271_1628445_+	S-ribosylhomocysteinase	NA	NA	NA	NA
WP_050237153.1\|1629085_1630363_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_000091092.1\|1631454_1632900_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	2.1e-134	60.3
WP_000565349.1\|1632901_1633633_+	hypothetical protein	NA	NA	NA	NA
WP_000664170.1\|1633641_1634334_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	1.1e-61	56.3
WP_001142518.1\|1634343_1635033_+	polysaccharide biosynthesis tyrosine autokinase CpsD	A0A1X9I5D6	Streptococcus_phage	3.0e-70	60.9
WP_000343584.1\|1635043_1636411_+	sugar transferase	NA	NA	NA	NA
WP_001205627.1\|1636414_1637158_+	WecB/TagA/CpsF family glycosyltransferase	NA	NA	NA	NA
WP_001076786.1\|1637154_1637979_+	LicD family protein	A0A1V0SD50	Indivirus	1.8e-05	38.7
WP_000458863.1\|1637980_1638859_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000120848.1\|1638859_1640197_+	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_001092839.1\|1640219_1641641_+	hypothetical protein	NA	NA	NA	NA
WP_000723326.1\|1641704_1642793_+	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SAG5	Catovirus	1.0e-27	30.3
WP_000676141.1\|1642831_1643701_+	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	2.0e-100	62.8
WP_000131456.1\|1643701_1644298_+	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	H9NC63	Sphingomonas_phage	3.9e-10	33.1
WP_000141499.1\|1644307_1645357_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	8.3e-72	44.5
WP_000600901.1\|1645422_1646274_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	2.5e-26	35.0
WP_025169503.1\|1646370_1646784_+\|transposase	transposase	A0A218MNE7	uncultured_virus	9.0e-06	24.6
WP_000245755.1\|1646856_1647114_+\|transposase	transposase	NA	NA	NA	NA
WP_050239038.1\|1647159_1647306_+\|transposase	transposase	NA	NA	NA	NA
WP_001811052.1\|1647376_1647535_+\|transposase	transposase domain-containing protein	NA	NA	NA	NA
WP_000842609.1\|1647733_1649716_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_100931688.1\|1650015_1655334_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_001040025.1\|1655500_1657660_-	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_000248787.1\|1657656_1658253_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	8.7e-18	33.9
WP_000179555.1\|1658318_1658846_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_000146522.1\|1658915_1659245_+	cell division regulator GpsB	NA	NA	NA	NA
WP_000711391.1\|1659730_1660888_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_000039276.1\|1660900_1662295_+	mid-cell-anchored protein MapZ	NA	NA	NA	NA
WP_000158781.1\|1662370_1663795_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	1.6e-41	29.6
WP_000518016.1\|1663806_1664496_+	response regulator transcription factor	NA	NA	NA	NA
WP_000771105.1\|1664593_1665559_+\|holin	choline-binding protein CbpC	NA	NA	NA	NA

DBSCAN-SWA_11

1739856 : 1800973

Streptococcus_phage(15.38%)

bacteriocin,tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_100931690.1\|1739856_1741149_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.1e-240	97.7
WP_000989519.1\|1741126_1741360_+	hypothetical protein	NA	NA	NA	NA
WP_000904589.1\|1741385_1742447_-	DNA polymerase IV	NA	NA	NA	NA
WP_000260643.1\|1742794_1745119_+	formate C-acetyltransferase	A0A2P0VNR5	Tetraselmis_virus	7.9e-115	32.9
WP_100931691.1\|1745160_1746453_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	3.1e-238	96.5
WP_000359824.1\|1746906_1747464_-	hypothetical protein	NA	NA	NA	NA
WP_000384133.1\|1747456_1747741_-	hypothetical protein	NA	NA	NA	NA
WP_001812228.1\|1748352_1748523_-\|transposase	transposase	NA	NA	NA	NA
WP_001812227.1\|1749083_1749305_+	hypothetical protein	NA	NA	NA	NA
WP_001812226.1\|1749316_1749541_+	PTS mannose transporter subunit IIA	NA	NA	NA	NA
WP_001809506.1\|1749667_1751107_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000691685.1\|1751110_1752460_-	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_001063601.1\|1752647_1753496_+	S-adenosyl-l-methionine hydroxide adenosyltransferase family protein	NA	NA	NA	NA
WP_000403162.1\|1753510_1754059_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
WP_000693286.1\|1754065_1754323_+	hypothetical protein	NA	NA	NA	NA
WP_000656531.1\|1754424_1756107_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.5e-19	34.4
WP_001148103.1\|1756091_1756922_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000181374.1\|1757114_1757618_+\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000185835.1\|1758070_1758634_+	ECF transporter S component	NA	NA	NA	NA
WP_000653428.1\|1758623_1759274_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_000867290.1\|1759301_1759691_+	chromosome partitioning protein ParB	NA	NA	NA	NA
WP_000333647.1\|1759695_1760145_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000418402.1\|1760272_1760860_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_000105232.1\|1761249_1762857_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	2.0e-141	47.0
WP_000026646.1\|1763415_1765047_-	Na/Pi cotransporter family protein	NA	NA	NA	NA
WP_000795172.1\|1765339_1770319_+	bacterial Ig-like domain-containing protein	NA	NA	NA	NA
WP_001096743.1\|1770408_1771605_+	phosphoglycerate kinase	NA	NA	NA	NA
WP_000119900.1\|1771740_1772268_+	aromatic acid exporter family protein	NA	NA	NA	NA
WP_000659547.1\|1772344_1772701_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_001122900.1\|1772737_1774084_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_001808898.1\|1774179_1774299_-	hypothetical protein	NA	NA	NA	NA
WP_000410533.1\|1774263_1774413_+	hypothetical protein	NA	NA	NA	NA
WP_001220774.1\|1774864_1776145_+	restriction endonuclease subunit S	A0A1V0SKS6	Klosneuvirus	2.4e-12	29.8
WP_000651181.1\|1776201_1776999_+	tyrosine-type DNA invertase PsrA	A0A0H4TI16	Erysipelothrix_phage	1.7e-21	28.7
WP_061450986.1\|1777009_1777615_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_050262906.1\|1777562_1779113_-	restriction endonuclease subunit S	A0A1V0SLK8	Klosneuvirus	1.7e-12	25.6
WP_000029046.1\|1779112_1780576_-	SAM-dependent DNA methyltransferase	NA	NA	NA	NA
WP_000229085.1\|1780588_1782922_-	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	2.0e-25	28.9
WP_001088687.1\|1783529_1784039_+	DUF2812 domain-containing protein	NA	NA	NA	NA
WP_000255769.1\|1784202_1785237_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_000046031.1\|1785263_1785788_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_000034662.1\|1786267_1788091_+	molecular chaperone DnaK	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.3e-133	47.2
WP_000114421.1\|1788092_1788449_+	hypothetical protein	NA	NA	NA	NA
WP_001066301.1\|1788850_1789987_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	1.7e-22	31.0
WP_001812223.1\|1790308_1790548_-	hypothetical protein	NA	NA	NA	NA
WP_000777760.1\|1790709_1790997_-	hypothetical protein	NA	NA	NA	NA
WP_001278301.1\|1791006_1791417_-	HIT family protein	B5LJ12	Mycobacterium_phage	3.4e-05	31.6
WP_000889919.1\|1791484_1792216_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.1e-25	28.6
WP_000653766.1\|1792212_1793262_+	ABC transporter permease	NA	NA	NA	NA
WP_000132572.1\|1793429_1793759_-	hypothetical protein	NA	NA	NA	NA
WP_000876675.1\|1794034_1794373_+	response regulator transcription factor	NA	NA	NA	NA
WP_001219120.1\|1794377_1795115_+	response regulator transcription factor	NA	NA	NA	NA
WP_001017644.1\|1795128_1796469_+	sensor histidine kinase	NA	NA	NA	NA
WP_000358817.1\|1796510_1796666_-	quorum-sensing system pheromone BlpC	NA	NA	NA	NA
WP_001069082.1\|1796722_1798084_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA
WP_001093257.1\|1800499_1800754_+\|bacteriocin	two-peptide bacteriocin subunit BlpM	NA	NA	NA	NA
WP_001099490.1\|1800769_1800973_+\|bacteriocin	two-peptide bacteriocin subunit BlpN	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP025076

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection