CRISPRimmunity

Please click to download your results

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018757	Bifidobacterium bifidum strain PRI 1 chromosome, complete genome	2 crisprs	cas3,WYL,csa3,DEDDh	0	0	2	0

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018757_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018757_1

45886-45971

Orphan

Consensus_repeat	Method
CGTTTGCGTTCCTAAGTGCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018757_1

>merge|NZ_CP018757|1|45886-45971|CRISPRCasFinder
CGTTTGCGTTCCTAAGTGCGCGCCGAACCGGCAAGTGCGCGCACATAGCAACGCAAATGGCCCTGTTTGCGTTCCTAAGTGCGCGC

>NZ_CP018757|1|1|45886-45971|CRISPRCasFinder
CGTTTGCGTTCCTAAGTGCGCGC	CGAACCGGCAAGTGCGCGCACATAGCAACGCAAATGGCCC
TGTTTGCGTTCCTAAGTGCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018757.1\|WP_047272452.1\|50190_50436_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|378873
NZ_CP018757.1\|WP_003821602.1\|45029_45728_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018757.1\|WP_003813432.1\|39307_39910_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|376808
NZ_CP018757.1\|WP_047272299.1\|40739_41633_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018757.1\|WP_003820255.1\|48551_48737_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018757.1\|WP_047272301.1\|39885_40437_-\|putative-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377672
NZ_CP018757.1\|WP_047297685.1\|41617_42094_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018757.1\|WP_047272296.1\|46128_46824_-\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837
NZ_CP018757.1\|WP_003813438.1\|36555_36960_+\|flavin-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|226105
NZ_CP018757.1\|WP_022174106.1\|52672_53041_+\|DUF488-domain-containing-protein	unknown	unknown	gnl\|CDD\|225730
NZ_CP018757.1\|WP_047272304.1\|37126_37948_-\|winged-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|294013
NZ_CP018757.1\|WP_047272294.1\|46928_47123_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018757.1\|WP_047272302.1\|38241_39261_+\|teicoplanin-resistance-protein-VanZ	unknown	unknown	gnl\|CDD\|377417
NZ_CP018757.1\|WP_047272289.1\|51836_52475_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP018757.1\|WP_013389991.1\|44685_45114_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NZ_CP018757.1\|WP_101357136.1\|43268_44231_-\|cobalt-transporter	unknown	unknown	unknown
NZ_CP018757.1\|WP_080829344.1\|47605_48568_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|119345
NZ_CP018757.1\|WP_080580131.1\|51303_51792_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP018757.1\|WP_082247892.1\|49813_49972_-\|permease	unknown	unknown	unknown
NZ_CP018757.1\|WP_003820246.1\|53112_53964_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214

Protein	Function_ID	Function_description	E-value
NZ_CP018757.1\|WP_047272452.1\|50190_50436_+\|NUDIX-hydrolase	gnl\|CDD\|378873	pfam12535, Nudix_N, Hydrolase of X-linked nucleoside diphosphate N terminal. This family of proteins is found in eukaryotes. Proteins in this family are typically between 847 and 5344 amino acids in length. These enzymes hydrolyze the molecular motif of a nucleoside diphosphate linked to some other moiety, X.	1.02361e-21
NZ_CP018757.1\|WP_003813432.1\|39307_39910_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|376808	pfam02525, Flavodoxin_2, Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.	1.5492e-39
NZ_CP018757.1\|WP_047272289.1\|51836_52475_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.24547e-29
NZ_CP018757.1\|WP_047272301.1\|39885_40437_-\|putative-ABC-transporter-permease	gnl\|CDD\|377672	pfam06541, ABC_trans_CmpB, Putative ABC-transporter type IV. CmpB is a family of membrane proteins that are likely to be part of a two-component type IV ABC-transporter system. Families can transport multiple drugs including ethidium and fluoroquinolones. UniProtKB:Q83XH0 is a member of TCDB family 3.A.1.121.4.	7.4315e-22
NZ_CP018757.1\|WP_047272296.1\|46128_46824_-\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	2.51107e-58
NZ_CP018757.1\|WP_047272294.1\|46928_47123_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.51238e-06
NZ_CP018757.1\|WP_022174106.1\|52672_53041_+\|DUF488-domain-containing-protein	gnl\|CDD\|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	2.02267e-51
NZ_CP018757.1\|WP_047272304.1\|37126_37948_-\|winged-helix-domain-containing-protein	gnl\|CDD\|294013	cd00383, trans_reg_C, DNA-binding effector domain of two-component system response regulators. Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.	2.33184e-15
NZ_CP018757.1\|WP_047272302.1\|38241_39261_+\|teicoplanin-resistance-protein-VanZ	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	2.63806e-20
NZ_CP018757.1\|WP_013389991.1\|44685_45114_+\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.18989e-41
NZ_CP018757.1\|WP_003813438.1\|36555_36960_+\|flavin-nucleotide-binding-protein	gnl\|CDD\|226105	COG3576, COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only].	1.57357e-12
NZ_CP018757.1\|WP_080829344.1\|47605_48568_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	1.15822e-44
NZ_CP018757.1\|WP_080580131.1\|51303_51792_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.39733e-12
NZ_CP018757.1\|WP_003820246.1\|53112_53964_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	3.11953e-95

>NZ_CP018757.1|WP_003821602.1|45029_45728_-|hypothetical-protein
MDVSDVIARREFMPTYIWLDVAFLIGFAALLVWRRKYMTLLVGLVMGGVYFAVGYGAFNLLTHSRSISGGSMFWVLLWMSVSYGFTNFSWLWLWLSRDRHLAEWSMLILVWWFCCPLMSQTFTARFASGMQPIVIQRTTGAYHGWMAVILSRRRMVGHAVCRRSAWIPADQARDRRRYPKHLMYERTSISPTLLYSRTTIVRTACQRWFSNHPAQSTTASMLLPSGSSTNAE
>NZ_CP018757.1|WP_013389991.1|44685_45114_+|VOC-family-protein
MAYAARTVAGMLDHITLHVRDVGRSIAFYEHALAPLGYIVKAHHEPTLGFGVDDGTPHSDFYVSPLDDAALAPPPTHIAFLAPNREAVRGFHAAALAVGGRDNGTPGPRPYHPGYYSAFVLDPDGNNIEAVVDWAGWFENHR
>NZ_CP018757.1|WP_101357136.1|43268_44231_-|cobalt-transporter
MRRTVIIVAVMLCAAIALFVSIPRLMRFVWPASGPEPRRASDAYCSATLSSGDNKEMLSVEQALNAEIITRAAVKRGLPDHAATVAIATAMQETRLMNLSYGDRDSVGLFQQRPSQGWGAKEQLMDETYAANRFYDELVKVPNWQSVPVEDAAQSVQRSQYPDRYADWTNLARTWAAGLTGETGAGVACALEPAQPSDADMDGLTSDFRNEFPTVMVSPPSSLEPSSKTQDDGGDKAADNSAANDGSGKTTSKTLTFTMSAGTDTENGKRLCRQATAWLVVHARRYGIDSLRANGMRWNRTDGVWAGTETGDLTITATLA
>NZ_CP018757.1|WP_047297685.1|41617_42094_-|hypothetical-protein
MSFLFRHRDPGSRHVYRYGPLRITCVDRDVPIDVRVNAHLMYKVVLSWEDKARCATPFDMIPRDLGEFWLLDQWSTVGLHGWIRSPLNYGSSRTILRLFTSAFFHAAHARRPRYVQLLDEHRHAARHRAQPVADRLERWANRRTNRRCAHAGRPWKPP
>NZ_CP018757.1|WP_047272299.1|40739_41633_-|hypothetical-protein
MEAAIGMEIREHKSSFAVYVVLRVLVIAVAVLEFFNGDYEAVFLCILTLLLLLAPAFVQVRFRIELPSALEVIVLVFVFAAEILGEISSFYEIFPFWDTVLHTMNGFLAAAIGFSLVDLLNRSDRVKFELSPLYLAIVSFCFSMTIGVVWEFFEFSMDMLFGFDMQKDAVVHSISSVMLDPAHANHAIHINDITQVAVNGRDLGLGGYLDIGLIDTMEDLIVNFIGAVVFSVIGFIYVKNRGKGVSVISRFVPRRKSHDRDYLRLAGGDGDAPLAPGAQAHQAQRQSQHDPHHHDHP
>NZ_CP018757.1|WP_047272301.1|39885_40437_-|putative-ABC-transporter-permease
MAIVIALRRIDLGWKVVLVGGLAGGMLEFAMSLIQQYLLGSRSWNYANEPLNIGGRTTVPFMLFWGLLCYLIVRFILPLVLWLVHLIDDTWHTRLATILLAWILIDSVVTPPAIFLYGQRANGVVFDNWFAQHIRRLSMTTSCACISRTCACESHRGSSGTIYRPPARSAVMAYGRHARLAPS
>NZ_CP018757.1|WP_003813432.1|39307_39910_+|NAD(P)H-dependent-oxidoreductase
MSNNILVITSNPEKDSMTDAVGAAFAAGAVERGASADVLDLYDEGFNPVYSAADRAHYLGHAPMPEDVVPIQRRLAQADVIALVFPIYWYTMPAMVKGLFDRVICRGFAYHPDGTPGALADKTVRVIMLTGGSRQWYESDGIGESLDNQICRQTFAKYCGVKDVELVYVDNLSMGDDSSDKRKAAAAQLEGIRQLGASLA
>NZ_CP018757.1|WP_047272302.1|38241_39261_+|teicoplanin-resistance-protein-VanZ
MGFFESFSAPFMMSVALWPLVSFIVTVPVLAMLYHRDNRLGFGAALSEYATVLYLIGLLCFTLYPMPDDPAAYCATHHLHPQLNPLQFIGDIRADGLTAILQIVMNVVFFVPLGFIMKRVFRWKFAVALPVGFLASLLVETMQLTGVMGVFPCSYRLFDVDDLIWNTSGAVIGYGCAMLFDRLFPPRRTDMQTVTRPGFVRRFVAFLIDMGLVVVCATPVGVAAMVLVTMVSGRPGADVQRMRLLGPLGFGDIAMLVMLVLFEWVIPWFRQGRTLGGSYTHMTCETTPRSGARRVAFYTARFTAICCVVFCGRVPWAGAVILVMGVFWLVRRQMPYDLI
>NZ_CP018757.1|WP_047272304.1|37126_37948_-|winged-helix-domain-containing-protein
MDILFVTSDPALASAVKGTLESARHTVSAASDVDSLAGAWPHGTPMDLVIIDDLSAHDLLDETRRSLSRLMDGKAGDGTGTAVRPRTLLLSTPPRTPKANPDDTPQVRRQTPLPTIRKTGRDKADGQAARPAAPPSSLDGASSVPSIHADETIVKPFSDAELLSYVRALESGGAADETTLIHGDLMLDTRNRQAFYRSGKQPLALSAREYTTLETLIRANGEFLSFDELLEKVCGTGIFEQRDIMDGTLYSLTRKMRRMGFFITQRGHRYRIR
>NZ_CP018757.1|WP_003813438.1|36555_36960_+|flavin-nucleotide-binding-protein
MATLTADMKTFIENNLAWITTVDKDGNLDLGPKMSMFVLDDNHLAYHERTAGQHYRNLQDGSPLVVAVANLAEKKGYRFRGTVTLHTDDDIYDAQVKVAEEKGTKKPAAIPVLEITEIQDLSSGATAGKTIDKD
>NZ_CP018757.1|WP_047272296.1|46128_46824_-|SOS-response-associated-peptidase
MCKRFALDLDWDAIAAQFSVAKEDVRGDVLPRPSYNITPTQNIAVIAQGKDGHRHLTGAYWSLIPSWSSGKTLPYPTYNARVESAHVKSTFAESTRSRRTIIPASGYYEWKGRRPFYFSPEMESTALAMAGLYSWRRPSAASLWQLTATILTCPAVDGPATVHDRMPLLVPAGMTSEWLDPSIDGARLLAPMRKAGAELSARLHFHEVAPPEGDGPSLIRPINREEPMRLF
>NZ_CP018757.1|WP_047272294.1|46928_47123_-|HAMP-domain-containing-histidine-kinase
MANRPGHGLGLSIAKACTDAMQATLAVSRPAPGTFRAEIKLPNRPTQRYCPQQKEHGHRPHARQ
>NZ_CP018757.1|WP_080829344.1|47605_48568_+|GNAT-family-N-acetyltransferase
MRLTEVWRADPERTFELFSEFPADENGFENQAAGMDRERFAVYVHELEEQSRGIGLQPGWVPSSKYVLINDEGAYVGIFNLRHRLNDNLRVGAGHIGYGIAPQYRGRGYATVGLRLTLDKARELGIDEAYLSVHKDNRASLAVQQHCGARIDHEDGLEYYTRISTAPEPGNLPKAEFMFPGPERDRLVGLILAGTKTATAALMIEYEEDDEPLPQVGERSALVDSSERPVAILVTTAVDVIPLGKITDRHAIDEGEGDTTAAAWRHTHESFWNAPEYRNEFADPDFSLNDDSLVVFEHFKVVRLLDSMANKTADGYEQQV
>NZ_CP018757.1|WP_003820255.1|48551_48737_+|hypothetical-protein
MNSKYEVIRQFVAAHGGRAELIEHETAIEDSYHTLAIDPRLVVECNAIAGCFNGEDFVKPL
>NZ_CP018757.1|WP_082247892.1|49813_49972_-|permease
MLNLATTLGQAVGPSITSAVKTVTGTFTAAFAISIVMAPCAAGFVLSLRKVR
>NZ_CP018757.1|WP_047272452.1|50190_50436_+|NUDIX-hydrolase
MIAADRTLLEQARELQALAQTGLAYCKDPLDRERYERIRAIAVDMLAMQADVPAEEMRRPLGAGYPTPKLDTRAAIATPTG
>NZ_CP018757.1|WP_080580131.1|51303_51792_-|GNAT-family-N-acetyltransferase
MTTRIVPIEPQWFMQKAEVQSRTWRELNQGHIPQDIVDAITPAFALKLTRGHAADPNQVVLIALADDRVVGFIELLRTPRPPINRPEAAELASLYVLESEHRHGVGRALVEAGRQAVGNDRLVLWVVGFNTNAQGFYRHIGFHETGLTQTEDMGPELEMINY
>NZ_CP018757.1|WP_047272289.1|51836_52475_-|GNAT-family-N-acetyltransferase
MDTIETERLLLRPWKVDDAAEAASLFRYASDPEIGLRCGWPPHTSVEGSMHDIRNILAVENNWAITIKGGAPNSNAPVGSIALKPVSHRTADAVAADPELTKRYGKYLGDSALELGYWIGRPFWGKGYMPEALTAVLGYAFDTLRKDAVWGGHFAENTQSGRVQAKCGLHVVAESKQDYFPLIDRHYDCVYRIITAGEWRDAEHRQMARMIA
>NZ_CP018757.1|WP_022174106.1|52672_53041_+|DUF488-domain-containing-protein
MGRMGIAIKRIYESPEAPDGYRVLVDRLWPRGMTKERAALDLWMKDVAPSPQLRKWFGHDPARFAEFRAQYITELDANAAAEELLRICAEYPDVTLLYAAKDPQVNHALVLRDYLEDATAAK
>NZ_CP018757.1|WP_003820246.1|53112_53964_+|deoxyribonuclease-IV
MKELYIGSHLSTAGGWSALLKRSHEEHGTTFAFFPRSPYGRPSKALNPSGAVAFARQLTAEHYGPLVVHAPYVYNLAGKDPDKREFAIRALAEDIRLLTPIRETGQEIYINIHPGAHVGQGPDRGCSLISDGLNRVFGLEPGIMVLLETMAGKGTECGRNFEELATIIDGVDDKANVGVTVDTCHVLDAGYDLVNDFDGVMRQLDDVIGLERVKAVHVNDSQFGLSSHKDRHANIGDGHLGIPFFTRMVNDPRLSRLPMILETKELTETTHREEIALLRGLVQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP018757_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018757_2

1146080-1146175

Orphan

Consensus_repeat	Method
CGTCACCGTGTGCGGGGGCGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018757_2

>merge|NZ_CP018757|2|1146080-1146175|CRISPRCasFinder
CGTCACCGTGTGCGGGGGCGCACAGCGTGACGGCATTCCGGAACCATTGCAATCACTGGATTCTTGAAGAATGCGTCACCGTGTGCGGGCGCGCAC

>NZ_CP018757|2|2|1146080-1146175|CRISPRCasFinder
CGTCACCGTGTGCGGGGGCGCAC	AGCGTGACGGCATTCCGGAACCATTGCAATCACTGGATTCTTGAAGAATG
CGTCACCGTGTGCGGGCGCGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018757.1\|WP_047271202.1\|1153409_1154462_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP018757.1\|WP_003815072.1\|1158433_1158913_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|153102
NZ_CP018757.1\|WP_047271197.1\|1146333_1149831_-\|DUF5011-domain-containing-protein	unknown	unknown	gnl\|CDD\|226064
NZ_CP018757.1\|WP_047271203.1\|1154791_1155241_+\|PTS-transporter-subunit-EIIA	unknown	unknown	gnl\|CDD\|238129
NZ_CP018757.1\|WP_047271346.1\|1138012_1138411_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_CP018757.1\|WP_003815054.1\|1143220_1144567_-\|NADP-specific-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|181834
NZ_CP018757.1\|WP_047271205.1\|1159353_1160427_+\|drug/metabolite-DMT-transporter-permease	unknown	unknown	gnl\|CDD\|183277
NZ_CP018757.1\|WP_003817396.1\|1155364_1155637_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99905
NZ_CP018757.1\|WP_047297658.1\|1139793_1140021_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018757.1\|WP_013362847.1\|1145524_1145959_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NZ_CP018757.1\|WP_047271344.1\|1138388_1139291_-\|KilA-N-domain-containing-protein	unknown	unknown	gnl\|CDD\|367917
NZ_CP018757.1\|WP_047271200.1\|1150601_1152938_+\|family-20-glycosylhydrolase	unknown	unknown	gnl\|CDD\|119335
NZ_CP018757.1\|WP_015439062.1\|1140313_1141093_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NZ_CP018757.1\|WP_013389336.1\|1157505_1158246_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|307807
NZ_CP018757.1\|WP_047271245.1\|1141089_1142589_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP018757.1\|WP_101357197.1\|1144670_1145471_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP018757.1\|WP_047271343.1\|1139302_1139638_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215149
NZ_CP018757.1\|WP_013389338.1\|1160462_1161815_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP018757.1\|WP_013389335.1\|1155702_1157220_+\|PTS-ascorbate-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|236502
NZ_CP018757.1\|WP_157829222.1\|1140020_1140332_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018757.1\|WP_047271202.1\|1153409_1154462_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.00484e-73
NZ_CP018757.1\|WP_003815072.1\|1158433_1158913_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|153102	cd01043, DPS, DPS protein, ferritin-like diiron-binding domain. DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide. These proteins assemble into dodecameric structures, some form DPS-DNA co-crystalline complexes, and possess iron and H2O2 detoxification capabilities. Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation. Members of the DPS family are homopolymers formed by 12 four-helix bundle subunits that assemble with 23 symmetry into a hollow shell. The DPS ferroxidase site is unusual in that it is not located in a four-helix bundle as in ferritin, but is shared by 2-fold symmetry-related subunits providing the iron ligands. Many DPS sequences (e.g., E. coli) display an N-terminal extension of variable length that contains two or three positively charged lysine residues that extends into the solvent and is thought to play an important role in the stabilization of the complex with DNA. DPS Listeria Flp, Bacillus anthracis Dlp-1 and Dlp-2, and Helicobacter pylori HP-NAP which lack the N-terminal extension, do not bind DNA. DPS proteins from Helicobacter pylori, Treponema pallidum, and Borrelia burgdorferi are highly immunogenic.	1.53638e-35
NZ_CP018757.1\|WP_047271197.1\|1146333_1149831_-\|DUF5011-domain-containing-protein	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	2.51747e-22
NZ_CP018757.1\|WP_047271203.1\|1154791_1155241_+\|PTS-transporter-subunit-EIIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	5.79388e-33
NZ_CP018757.1\|WP_047271346.1\|1138012_1138411_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	4.00156e-09
NZ_CP018757.1\|WP_003815054.1\|1143220_1144567_-\|NADP-specific-glutamate-dehydrogenase	gnl\|CDD\|181834	PRK09414, PRK09414, NADP-specific glutamate dehydrogenase.	0
NZ_CP018757.1\|WP_047271205.1\|1159353_1160427_+\|drug/metabolite-DMT-transporter-permease	gnl\|CDD\|183277	PRK11689, PRK11689, aromatic amino acid efflux DMT transporter YddG.	2.65256e-113
NZ_CP018757.1\|WP_003817396.1\|1155364_1155637_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99905	cd05563, PTS_IIB_ascorbate, PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a transmembrane channel IIC subunit. Subunits IIA, IIB, and IIC are encoded by the sgaA, sgaB, and sgaT genes of the E. coli sgaTBA operon. In some bacteria, the IIB (SgaB) domain is fused C-terminal to the IIA (SgaT) domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include ascorbate, chitobiose/lichenan, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	2.38629e-23
NZ_CP018757.1\|WP_047271344.1\|1138388_1139291_-\|KilA-N-domain-containing-protein	gnl\|CDD\|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	9.24292e-18
NZ_CP018757.1\|WP_013362847.1\|1145524_1145959_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	1.07766e-36
NZ_CP018757.1\|WP_047271200.1\|1150601_1152938_+\|family-20-glycosylhydrolase	gnl\|CDD\|119335	cd06565, GH20_GcnA-like, Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine residues from 4-methylumbelliferylated (4MU) substrates, as well as cleaving NAG from chito-oligosaccharides (i.e. NAG polymers). In contrast, sulfated forms of the substrate are unable to be cleaved and act instead as mild competitive inhibitors. Additionally, the enzyme is known to be poisoned by several first-row transition metals as well as by mercury. GcnA forms a homodimer with subunits comprised of three domains, an N-terminal zincin-like domain, this central catalytic GH20 domain, and a C-terminal alpha helical domain. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	4.84595e-87
NZ_CP018757.1\|WP_015439062.1\|1140313_1141093_-\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	1.35809e-59
NZ_CP018757.1\|WP_047271245.1\|1141089_1142589_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.06302e-23
NZ_CP018757.1\|WP_101357197.1\|1144670_1145471_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.02184e-23
NZ_CP018757.1\|WP_047271343.1\|1139302_1139638_-\|hypothetical-protein	gnl\|CDD\|215149	PLN02265, PLN02265, probable phenylalanyl-tRNA synthetase beta chain.	0.00499922
NZ_CP018757.1\|WP_013389338.1\|1160462_1161815_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.38016e-113
NZ_CP018757.1\|WP_013389335.1\|1155702_1157220_+\|PTS-ascorbate-transporter-subunit-IIC	gnl\|CDD\|236502	PRK09410, ulaA, PTS system ascorbate-specific transporter subunit IIC; Reviewed.	3.65397e-171
NZ_CP018757.1\|WP_013389336.1\|1157505_1158246_+\|M48-family-metallopeptidase	gnl\|CDD\|307807	pfam01863, DUF45, Protein of unknown function DUF45. This protein has no known function. Members are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C-terminus being the most conserved region, containing three conserved histidines. This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	3.42093e-46

>NZ_CP018757.1|WP_013362847.1|1145524_1145959_+|large-conductance-mechanosensitive-channel-protein-MscL
MIDGFKKFISRGNMIDMAVGVVMGGAVTAVVNAIVNHLINPLIAMIFGKPNMDGLLAFTFNGATVSVGAILGALLNFLIIAVAVYFFILVPINKFRDMSDALLAKAKLKESEAEDADEVKEPEPTAEQQTIALLTEIRDQLAKA
>NZ_CP018757.1|WP_101357197.1|1144670_1145471_-|FadR-family-transcriptional-regulator
MRGLQPAHRHLPDYRIILVAFRGRPASGTGHVAAELGAHRGDHTQDVVGVAARSLPGVKRRRGGRRGDAEFQRRFDVSRTVAREVAKSLETAKVVTVRRRIGLVSQPVEEWDALSTQVIHWKLHSTHRKEQLRTLTELHLAIEPAAATSADRYAPIDVKSRLPLLAAELRHTGENGRLDEFHKLDIEFHSLILRNSGNEMFASLSTIIATVLSGRVELHMYPQKPNPEALDAHDAVAQAIWQSSPDNARQAMHRIVDEVAETLQLS
>NZ_CP018757.1|WP_003815054.1|1143220_1144567_-|NADP-specific-glutamate-dehydrogenase
MLTDEYVKRVYAQVEQRDGDQPEFLQAVREVFETIQPVVEKHPEYEKAGVLERIVEPERVVKFRVAWTDDEGKVQVNRGYRVQFNSAIGPYKGGLRFHPTVNEGVIKFLGFEQILKNSLTTLPMGGGKGGSDFNPKGRSDAEVMRFCQAFMTELCRHIGQFTDVPAGDINVGGREIGYLFGQYKRIRDEYSGVLTGKGLEFGGSLARTEATGYGVCYYTQEALRVLKNDSFEGKTVVVSGSGNVAIYAVQKAEELGAKVVTVSDSNGYVYDPNGIDVAVVKQIKEVERGRIKEYAERVPSAEYHEGCSGVWTVPCDIALPCATQNEVNGESAEALVKNGCKVVVEGANMPSTPEAIEVYQKNGLLYGPAKAANAGGVAVSGLEMSQNSYRLSWSFEEVDAKLKNIMETIVADSLAAAKEYGHEGDLMLGANAAGFVKVANAMVAQGIL
>NZ_CP018757.1|WP_047271245.1|1141089_1142589_-|IS21-family-transposase
MTIPVSVQQRIRLLDQQGTPWRAIARDLNVSRDTVRKYALMEDCSPKPKPSTTRPRKLDGFTPVIDEWLQADRFMPRKQRHTAKRVYDRLVTEKGFTGSYSAVQRYVKQWRQEHRPACDGFMELEWRPGVMQVDFGEAVVVLAGVKTKVHCLVASFPYSNKRYVVALPGENAQCVCEGLVEIFEHIGLVPMVLVMDNATGAAHRTAWDKITIVGLFQLFLEHYRIEARFCNPRSGWEKGSVENAVGFLRRNLMVPLLNVESYAQLSKHLLSRCDELGNDKHYRADESVNDLFEEDRAGMRPLPRVRFDAVDWQERRADKEGVIQVGSYRYLAGPAWRSWPLLVGLRAFDVEIRTRDGRKVASLPRAYGEQAGTVRSPSSLLPALARKPRAWGESPVRGDFPEGLRTLIDAQDSARRKATFRLLERVGAACGFDVACKAAEHIIGQGRPIDEAALSIMARRIASGEAPADVPAPDLSVYDDFMKTGDGDTLKEREGGKDR
>NZ_CP018757.1|WP_015439062.1|1140313_1141093_-|ATP-binding-protein
MSRIQNPAPDATRRRASTNRKMETIMRLARRLPLTRQVLADQLETATPSQMEFMDQWMNAEIESRERSKRSRLLKQAGFPAVKTLDGYDWENIRFPVDWGRRSLESLEFASRPEDVVMFGPPGTGKTHLAMALGRKACLEGMTVRFFTAAGLVMRLLHASTEGKLDREIASIGKARLLIIDELGYVPIDEEGSRLLFQVITNAYEMQSIVYTTNIEFSGWGRVFGDPNMAAAIIDRTVHHGRMLRFEGESYRRTHALMQ
>NZ_CP018757.1|WP_157829222.1|1140020_1140332_+|hypothetical-protein
MTRLTDNDGREFTVTRTPQVESAGYPCLFAVTLDGHTAVRVTKGGLQSIKQEINRALRETSVFCQVVIGQCGVSFPSEKAVGFSPVRNWPVIARVLLFHCIRA
>NZ_CP018757.1|WP_047297658.1|1139793_1140021_+|hypothetical-protein
MAVDGLRREARAAEVPQADIGQVIGKSRQTVNVKFRSGDMRLTEFVNIAQSLGISPHKVLERAEKNAALADKKVA
>NZ_CP018757.1|WP_047271343.1|1139302_1139638_-|hypothetical-protein
MIDFFAEKKADEGNPSLRVLAARLGMKHTRVGDLFNKTNGTPTLQEFIDLCLGFNVKPSNVLDEVIAKAARARAERTADEVADRIAANPDDFDVAASIDPHKRDEANTPRE
>NZ_CP018757.1|WP_047271344.1|1138388_1139291_-|KilA-N-domain-containing-protein
MASLKKTVQETLSINGLDVAIRGNGDENDYISLTDLAREKVGPEGDPRFAIGNWMRLKDTIALLGIWEKLNNPDFKRVEFDTFMGEAGRNAFTMTPSRWITATNAIGIQSRRGRNGGTFAHVDLALDFAAWISPEFRLYVFQEYKRLKKDESSRLNAEWNEKRLFAAMNYRVHTDAIKDMMPPHLSRNDQRIRYAQEGDVLNIAVFGRTARQWRDANPNAKGNMRDYASITQNLVLSNLENLNAEMIRDGKSIRERMLKLNEIARRQMELFNSHPTVRKLEAEEHHHIEKPEVNENDDLR
>NZ_CP018757.1|WP_047271346.1|1138012_1138411_-|ImmA/IrrE-family-metallo-endopeptidase
MKTTTYADLLGEAELLGVDVRERSLGSDLAGCYYDPNRLIIIDETLPDFARRCTLAHELVHARYHDRGCDPNGSKAERRARRETALRLINPTEYAIAERMYEGDSYLIAQALDVTVQVVEDYKEMLHDSVAV
>NZ_CP018757.1|WP_047271197.1|1146333_1149831_-|DUF5011-domain-containing-protein
MTHITSHRRSGKLWRSIMAAIATAAMALSPGAAAYAADADATAPATTASANLRGAWNFENTAAGDREAANNGGSSSATAQLIGDDISIIADPAGVFGNVLHFGAGASSYMKINQYVNTGAGNASFAMWYRYDTTLDPTGDKPAVLLQQDGAGRSLLTLRPSNQYHTYVNATDVLSNNTVARGGWQHIAVSFDQTSHKVKFYVNGALDSEKNMGTSAVNAVTALLVGSHKNIGTMDPHSMKGDVDDIRVYDATLTDDQAAAIYAEQGTALVRKQLGTLVSQADALLAAGEVDAASAQAQALATAKRNAVNAMNNTSGSAAARMTAMNAAGTALQTAITAYQAHVPITLTADPSTVERTVDSASIFGVNHRYAFNGYGSFDPDTMRVKDDFTALYKQVGFGSIRYPGGTISNLFNWKTTIGPRAQRLKQMHGFYNNPGQGGIEPNFGIGEIATFADEVDSEIVYVYSLGRGNAQDAADLIEYLNAQVGTNPNGGIDWAKVRADNGHPQPYNVRYFEIGNEMNQAWANSDGTASQGYWTTAVSGGSEQAYTEGGTASFTKQYAVSLEDWNKAASVSDGKAGLTRYMRYANVNPKMNGDNGAIVDDPSFVAVNKGSVSVWVGNDQSNEQWRIVDDLETAGAGDKVVQVDYSTGALRFGDGVHGAIPAKGQQVYVSYTVDRDGFVKISKAIKNTTDQINTAEQRTDGTRHTANVYTSYESTGFITRMANLNANQWYDGMTIHPYSGTPTGATAGAWYDDAMKKAETAGVNRVKEYVRLMPAGKVPVISEYGIFRDTSALVRSQSHALYIAKVALEYVRLGSPYIQKHCLIDWYSSGADSLGPTQQAVIQAVPEDGASTVTGEGRFGFFLTPSAYALQMLGNGIGDSVLTSTLGSTPTLGNGATALSALVSKDDDGNLRVIIVNLDRALGRTLKLNFGQDLSGRVADVQTMDAAINAENTLENQDNVTPVDSSVTFDAATPTVTVTPHSLTTLKIRPRAAGTINAAPVITASDRTITVGDAFDPLDGVTAHDAEDGDMPLAAANVTADDVDPDTPGTYHVTITVTDSQGATTSKTFTVVVQAKEGGETPEPEPDPSPGPEPTPEPAPKPAPDEKTDQAAHQKPDDKTNGQQADNGKTKLSHTGVSVLVALTCTAMLAIGGGLIATFRRKRS
>NZ_CP018757.1|WP_047271200.1|1150601_1152938_+|family-20-glycosylhydrolase
MSFDLIPEPQSVTLNGDAADSDDAGAPVPVALPLVGRISEDRDIDDIAGVFPTQLADDIEAATGLRWDIASDVMVAGLPAPNAAIAHPVPPHASCWKSFITLRLDPSSLEPQEYRLTIARSGIDVVGGDTEGVRNGVQTLRQIIRQCAPALPRLVIADKPAYKVRGYYLDATRGRVPTLDWLKTWADRLCLYKYNQLQLYIEHTFMFDDLSETWRGTSPLKPADIITFDEYCARLGIELVPSVSTFGHQYMAMRTRELRHLGEFPEDADRRYGFVERQRHHTLNITEPESLAFSFKLIDAYMQLFRTRKFNICGDETFDLGRGRSKPEAERRGVATMYADFVSQLCRHLSERGREPMFWGDIAVEMPQILGLLPDNVTLLNWLYAPGIGEDKVRLVAQAGAPQYVCSAVWCWNALLPRLDDSWNNISRLARYGVKYGAVGYLVTDWGDYGHVNDPRMAVSGMIFGAQCAWNPMAHIQGEAGCGDGEEGSAAGYADAAADAVRENKAAADGDSPAPLPLSSESDDYTGGAADAIAGAPAGGDGSCAEMCRRVAEVEYGDRSGGIVEALRDAACRVAFGWDDMVWYCELDEGDGRMNRDAASAMHLGVHGFSGEYGREWDARLLGSTDLDEARRTMLQGLSPHIVRAAEANEALLCDAMRLGAAAGRASRLGAARRDVPAMLAAIEGQRWFNLVGLCLARRHDVITVDAGDIARASAGLIEPDAGSSAGPEAVQDVSIRVARGLERWFETYCDLWRSVSAESELARIASIVWRCADALRS
>NZ_CP018757.1|WP_047271202.1|1153409_1154462_-|LacI-family-transcriptional-regulator
MSSTSSITDVAALARVSKATVSRVLSGRRTKDDNIAKRVRDAAEQLNYQANSAASALRSDTTNTIGLIMPGPTDPLVARLLAELEPEVNRSGRQLLLGLGDDQRTQTERIEAMLARRVDGLVVMPPQDANTAAFLDDYVGMTSLVQAFGHSTSFHVNWVGVDESASMKLMLSHLAEYNANSIAFLSGNVNSDSAAELFATLQTSTRVMNLMTEPGWTTFGDNSAKRGYHDVMRLFGDKGNRPNALICATDDVAIGALMALNQLGIRVPDEVKVIGSGDSPAAAIADPPLSSILPPCRLIAHEALRLISVSASSKHWLPAHTAYPPQLVQRESTSGPRFGSSDMALPDDES
>NZ_CP018757.1|WP_047271203.1|1154791_1155241_+|PTS-transporter-subunit-EIIA
MVADIDGFLPDSAFLLDVPATDWKDAIRLAGKGLVAAGFTTDAYTDQMIETVEKMGPYIVIAPGLALAHSRPSEAVLKTGLSWVRLSTPVKFGNKANDPVSLVIGLAGHDENEHITVMSAIASSLINPKKTAALAAAPTPEAIRDILHQ
>NZ_CP018757.1|WP_003817396.1|1155364_1155637_+|PTS-sugar-transporter-subunit-IIB
MNILCVCGNGIGTSVLLKVNVESVAADLGVDVNVTTSDAGSAKGTANMNDLVLTSAELAPELEGTTTPVEVITNFMDTDEIKSVLEKYAD
>NZ_CP018757.1|WP_013389335.1|1155702_1157220_+|PTS-ascorbate-transporter-subunit-IIC
MNVVVQVLNFISQEILNVPAYLIGIIAAIGLIALKRSAGQVVSGALKAAMGYLILGAGATVVTSALAPFGDLVLKSTGAHGVVPTNEVITAQASSQYGASSAYIIVLSFIVMLLLARFTPLKYIFLTGHHMVFMSTMLAVVLSVGFGTDHQLLIVIIGAILMGVIMVVMPAFAQPFMNRVTGSDKLSIGHFNTLGYIVSGAVGAGVGKKSKSTEDINFPKGLSFLRDSMVSTTLLMVVLYLVFSVWAAIVLPAKEAFKIFSTNPDNYGSFFMAAFAQALQFGIGVSIILYGVRIILGELVPAFQGIANKVVPGARPALDIPIVFPYGANASLIGFLGSFVGGLVALAIIAVWLGPVWGVALILPGMVPHFFDGGGAGVFGNATGGRIGAVVGSFINGLLITFLPAALMTVMGSFGLANSTFGDADFCWFGTITGNMAHLGPVGGAICLLIFAAVLFAAAWIWQVKVVNTGWTPGAKHAEYIEQVKAEEKAAKAAARAAKKAAAEA
>NZ_CP018757.1|WP_013389336.1|1157505_1158246_+|M48-family-metallopeptidase
MPLPNQRRHARKAPASASTAAASTVLEVDGLQLHVTRKRIKNLYLRIKPPLGTVEVSAPMRMSQRQIIGFAHERHSWIVQQQRRMAEARRMSLRQAETLTPLPSAPAGDGEHAGVDGRRGGDQPQLPMFDRSAMWTDERKHAAAAAIDAALPGLLRKWAPIVGRSPSHVTLRVMTSRWGSCTPKTGRIRLNLQLGLMEPRFLEYVLVHEMTHLWANGHGADFQRRMSAYLPSWRELRRELNKRVLL
>NZ_CP018757.1|WP_003815072.1|1158433_1158913_-|DNA-starvation/stationary-phase-protection-protein
MTLAFVVPGLDEAASEKAIAILQNRLSQEQEAALVLKHAHWNVTGPNFIAVHEMLDPEVEAVLAQADETAERIATLGGTPDGRADAITRNRTWKPFDVDGRAGTEKYLEALIEYYDAFIADDRKAIAELDELDVISSNIIQDHVQELEKFQWFMRSHLA
>NZ_CP018757.1|WP_047271205.1|1159353_1160427_+|drug/metabolite-DMT-transporter-permease
MVDSRRDVAGQAGRSPSPSVQATMIGLMAILLWSLMTGLVRVVADAFGATLGSALIYTCGAVLLLVFRRPAPLRKYPRTYLIVGGLLFVFYESSISLSIGLASSAASSVEVSLVNYLWPTMMVLLAAAFVPSGEKRSVRNEGIGREPAAPSDAQAQDDSVQCGTNCSAGKPPRHSRGRAVLRVLPGAVVATAGVILAVGGNSGLDWALAAGHVAANPLPYLLAFAGALAWSVYAVFTPALSKGFDGTSVFFPFVAVALWIIHFASGQGWPSAAPSVWGYLAVVAAAAVIAGGYACWGYGILRGSMSTLAMASYATPVLSTAASAVLLGLSLTLPFWCGALLVAAGSIINWWISSQRR
>NZ_CP018757.1|WP_013389338.1|1160462_1161815_-|HlyC/CorC-family-transporter
MTCHPPTVESMSLGLNILLIFIFLVLGSIFSGTELALVSLRGSQIDQMEQEDARGARVAAIARDPNKFLSTVQIGVTLSGFLSASFGESSISPFIVPVVKSWGVPANIAAPLTTIVLTLIISYCSIVISEMVPKRIAMQRTEQIARAVVPAIDVFAKVCKPIIWLIGKNTNGIVRLLGFDPNETESEVSDEELRVLVNTNTSLSKDERTILDDVFDASETIVAEVMRPRADVVFLDGSQSIKDAAAYVREMPYSRYPVTGRDFDDVIGFVHVRDLLDVRDPNATTVADVTREGISLPGTSKLLPSLELLRKRGIHLAVVIDEYGGTDGIVTLEDMTEELVGDIRDEYDLPSEPGGERKEQPAFVSGVATIDASMTIEDFADLTGIELEDGPYETVAGYFLAHTGKMGAEGDVLHSDDGYDMTVTKVDGRRIETIEVRKAGAPDHAPVSAE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1135219 : 1218704

Escherichia_phage(30.0%)

integrase,transposase,holin,tRNA

attL 1192001:1192023|attR 1221471:1221493

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047271350.1\|1135219_1136359_-\|integrase	site-specific integrase	A0A0E3XBN7	Gordonia_phage	2.9e-70	41.1
WP_047271972.1\|1136538_1137414_+	hypothetical protein	NA	NA	NA	NA
WP_047271348.1\|1137526_1137997_-	hypothetical protein	NA	NA	NA	NA
WP_047271346.1\|1138012_1138411_-	ImmA/IrrE family metallo-endopeptidase	I3NLD5	Bifidobacterium_phage	2.0e-26	46.2
WP_047271344.1\|1138388_1139291_-	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	6.9e-67	46.4
WP_047271343.1\|1139302_1139638_-	hypothetical protein	NA	NA	NA	NA
WP_047297658.1\|1139793_1140021_+	hypothetical protein	NA	NA	NA	NA
WP_157829222.1\|1140020_1140332_+	hypothetical protein	NA	NA	NA	NA
WP_015439062.1\|1140313_1141093_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	1.7e-37	37.1
WP_047271245.1\|1141089_1142589_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	1.8e-11	24.6
WP_003815054.1\|1143220_1144567_-	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_101357197.1\|1144670_1145471_-	FadR family transcriptional regulator	NA	NA	NA	NA
WP_013362847.1\|1145524_1145959_+	large conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_047271197.1\|1146333_1149831_-	DUF5011 domain-containing protein	NA	NA	NA	NA
WP_047271200.1\|1150601_1152938_+	family 20 glycosylhydrolase	NA	NA	NA	NA
WP_047271202.1\|1153409_1154462_-	LacI family transcriptional regulator	C6ZCU4	Enterobacteria_phage	2.5e-15	25.1
WP_047271203.1\|1154791_1155241_+	PTS transporter subunit EIIA	NA	NA	NA	NA
WP_003817396.1\|1155364_1155637_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_013389335.1\|1155702_1157220_+	PTS ascorbate transporter subunit IIC	NA	NA	NA	NA
WP_013389336.1\|1157505_1158246_+	M48 family metallopeptidase	NA	NA	NA	NA
WP_003815072.1\|1158433_1158913_-	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_047271205.1\|1159353_1160427_+	drug/metabolite DMT transporter permease	NA	NA	NA	NA
WP_013389338.1\|1160462_1161815_-	HlyC/CorC family transporter	NA	NA	NA	NA
WP_101357198.1\|1161993_1162542_-	LacI family transcriptional regulator	NA	NA	NA	NA
WP_047271207.1\|1162685_1163369_-	carbonic anhydrase	NA	NA	NA	NA
WP_003817384.1\|1163651_1164215_+	peroxiredoxin	NA	NA	NA	NA
WP_047271208.1\|1164556_1166470_+	FAD-dependent oxidoreductase	G3MA85	Bacillus_virus	2.4e-48	36.2
WP_014759670.1\|1168546_1171303_-	phosphoenolpyruvate carboxylase	NA	NA	NA	NA
WP_082247834.1\|1171734_1173714_+	threonine/serine exporter family protein	NA	NA	NA	NA
WP_047271210.1\|1173786_1174878_-	amidohydrolase family protein	NA	NA	NA	NA
WP_047271211.1\|1175451_1176471_+	hypothetical protein	NA	NA	NA	NA
WP_047271213.1\|1176946_1178044_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_047271214.1\|1178184_1178565_+	DUF3073 domain-containing protein	NA	NA	NA	NA
WP_047271923.1\|1180199_1181225_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	3.2e-76	47.7
WP_047271216.1\|1181236_1181452_-	hypothetical protein	NA	NA	NA	NA
WP_047271218.1\|1181567_1184171_+	1,4-beta-N-acetylmuramidase	A0A1U9WQS3	Geobacillus_phage	7.2e-16	30.4
WP_047297650.1\|1184224_1185196_-	glycosyltransferase family 2 protein	V5USA4	Oenococcus_phage	2.9e-79	48.2
WP_080588994.1\|1186943_1187504_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.4e-33	39.6
WP_015439062.1\|1187904_1188684_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	1.7e-37	37.1
WP_047271245.1\|1188680_1190180_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	1.8e-11	24.6
1192001:1192023	attL	NA	NA	NA	NA
WP_082247907.1\|1193222_1194941_+	hypothetical protein	NA	NA	NA	NA
WP_047271226.1\|1196826_1197897_+	acyltransferase family protein	NA	NA	NA	NA
WP_047271228.1\|1197960_1199832_+	glycosyltransferase	NA	NA	NA	NA
WP_047271927.1\|1199979_1201071_+\|holin	phosphorylcholine metabolism protein	V5LSD6	Emiliania_huxleyi_virus	1.3e-06	47.5
WP_082247908.1\|1201089_1201833_+	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_082247909.1\|1201848_1202916_+	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_101357258.1\|1202996_1203821_+	ABC transporter permease	NA	NA	NA	NA
WP_047297697.1\|1203820_1205080_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.4e-09	24.6
WP_047271234.1\|1205142_1207140_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_101357199.1\|1207232_1208411_+	UDP-galactopyranose mutase	E4ZFQ1	Streptococcus_phage	2.8e-92	43.9
WP_082247910.1\|1208469_1209105_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_047271237.1\|1209108_1210863_-	hypothetical protein	NA	NA	NA	NA
WP_101357259.1\|1211024_1212050_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.2e-78	49.1
WP_047271241.1\|1212388_1213660_-	MFS transporter	NA	NA	NA	NA
WP_047271933.1\|1213816_1214479_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_015439062.1\|1214987_1215767_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	1.7e-37	37.1
WP_047271245.1\|1215763_1217263_-\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	1.8e-11	24.6
WP_047271246.1\|1217456_1218704_+\|integrase	tyrosine-type recombinase/integrase	I3NLE2	Bifidobacterium_phage	6.8e-89	44.4
1221471:1221493	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1235839 : 1302656

Bifidobacterium_phage(27.78%)

protease,portal,tRNA,capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047271262.1\|1235839_1236625_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_047271264.1\|1237578_1238907_+	DNA methyltransferase	NA	NA	NA	NA
WP_003816157.1\|1239032_1239488_-	cell division protein CrgA	NA	NA	NA	NA
WP_003816156.1\|1239565_1240354_+	DUF881 domain-containing protein	NA	NA	NA	NA
WP_047271266.1\|1240350_1241580_+	class E sortase	NA	NA	NA	NA
WP_003811402.1\|1241675_1242320_+	glutamine amidotransferase	A0A0P0IKJ1	Acinetobacter_phage	1.3e-35	40.7
WP_047271268.1\|1242552_1244619_-	Stk1 family PASTA domain-containing Ser/Thr kinase	Q8JE84	Murine_leukemia_virus	2.0e-16	31.8
WP_003816154.1\|1244621_1245605_-	serine/threonine protein kinase	T2AWK4	Cannes_8_virus	2.2e-18	29.9
WP_003820732.1\|1245601_1247068_-	penicillin-binding protein	NA	NA	NA	NA
WP_003811411.1\|1247064_1248543_-	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_101357203.1\|1248539_1250198_-	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_003811415.1\|1250204_1250747_-	FHA domain-containing protein	NA	NA	NA	NA
WP_003811419.1\|1250774_1251476_-	DUF3662 domain-containing protein	NA	NA	NA	NA
WP_047271939.1\|1251716_1254248_+	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_052773296.1\|1254472_1257298_+	YhgE/Pip domain-containing protein	NA	NA	NA	NA
WP_047271272.1\|1257294_1259622_+	YhgE/Pip domain-containing protein	NA	NA	NA	NA
WP_003816148.1\|1259774_1260830_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_101357261.1\|1260889_1261843_+	EamA family transporter	NA	NA	NA	NA
WP_047271275.1\|1262108_1262864_+	DUF1109 domain-containing protein	NA	NA	NA	NA
WP_047271276.1\|1262942_1263443_+	hypothetical protein	NA	NA	NA	NA
WP_047271942.1\|1263544_1264549_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_101357205.1\|1265403_1268589_-	DEAD/DEAH box helicase	U3PFS7	Lactobacillus_phage	1.7e-19	26.0
WP_017143690.1\|1268585_1269101_-	(deoxy)nucleoside triphosphate pyrophosphohydrolase	NA	NA	NA	NA
WP_082247839.1\|1269251_1269689_-	DivIVA domain-containing protein	NA	NA	NA	NA
WP_080959301.1\|1269722_1270043_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_003811449.1\|1270085_1270418_+	putative heavy metal-binding protein	NA	NA	NA	NA
WP_047271282.1\|1270539_1271358_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_080999910.1\|1271354_1271852_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_013389403.1\|1272486_1273788_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	2.8e-53	32.4
WP_047271284.1\|1274155_1276057_+\|protease	trypsin-like serine protease	A0A1B1IT49	uncultured_Mediterranean_phage	1.1e-13	25.8
WP_047271287.1\|1276435_1278628_+	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	7.9e-40	28.5
WP_047271288.1\|1278797_1280249_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_047271290.1\|1280420_1281359_+\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_017143391.1\|1281950_1282094_+	hypothetical protein	NA	NA	NA	NA
WP_101357206.1\|1282090_1282285_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_047271292.1\|1282343_1283159_-	CHAP domain-containing protein	I3NL82	Bifidobacterium_phage	5.4e-127	93.8
WP_003813084.1\|1283142_1283568_-	hypothetical protein	I3NL83	Bifidobacterium_phage	1.6e-66	98.6
WP_047271294.1\|1283579_1283798_-	hypothetical protein	NA	NA	NA	NA
WP_047284901.1\|1283794_1284202_-	hypothetical protein	I3NL84	Bifidobacterium_phage	6.7e-70	98.5
WP_157829223.1\|1284405_1284558_+	hypothetical protein	NA	NA	NA	NA
WP_047271296.1\|1284658_1285495_-	hypothetical protein	NA	NA	NA	NA
WP_047271298.1\|1285496_1285730_-	hypothetical protein	NA	NA	NA	NA
WP_047271945.1\|1285740_1287390_-	hypothetical protein	NA	NA	NA	NA
WP_047297655.1\|1287380_1288205_-	hypothetical protein	NA	NA	NA	NA
WP_052773297.1\|1288191_1290990_-	tape measure domain-containing protein	A0A1P8BLL5	Lactococcus_phage	2.2e-47	32.0
WP_082247843.1\|1291002_1291380_-	hypothetical protein	NA	NA	NA	NA
WP_047271301.1\|1291427_1291793_-	hypothetical protein	NA	NA	NA	NA
WP_047271303.1\|1292576_1292954_-	hypothetical protein	NA	NA	NA	NA
WP_047271305.1\|1292953_1293241_-	hypothetical protein	NA	NA	NA	NA
WP_047271307.1\|1293240_1293579_-	hypothetical protein	NA	NA	NA	NA
WP_052773299.1\|1293575_1293983_-	hypothetical protein	NA	NA	NA	NA
WP_082247844.1\|1293999_1294437_-	hypothetical protein	I3NL98	Bifidobacterium_phage	4.7e-21	48.9
WP_082247845.1\|1294436_1295396_-\|capsid	phage major capsid protein	I3NL99	Bifidobacterium_phage	2.6e-96	57.5
WP_052773300.1\|1295421_1295955_-	helicase	NA	NA	NA	NA
WP_133239685.1\|1295979_1296807_-	hypothetical protein	A0A1D8EU00	Propionibacterium_phage	3.5e-41	39.1
WP_101357207.1\|1296694_1298230_-\|portal	phage portal protein	A0A068F3B8	Mycobacterium_phage	7.8e-87	41.1
WP_082247846.1\|1298229_1299594_-\|terminase	terminase	A0A0S1S2I3	Propionibacterium_phage	8.2e-88	41.8
WP_052773303.1\|1299664_1300039_-	hypothetical protein	F8S0R2	Gordonia_phage	2.2e-06	32.6
WP_157829224.1\|1300307_1300685_-	hypothetical protein	NA	NA	NA	NA
WP_052773304.1\|1300859_1301477_-	hypothetical protein	NA	NA	NA	NA
WP_052773459.1\|1301466_1302159_-	hypothetical protein	NA	NA	NA	NA
WP_047271312.1\|1302155_1302656_-	hypothetical protein	A0A0A0RKU9	Mycobacterium_phage	7.5e-23	43.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018757

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection