CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP025441	Listeria monocytogenes strain MF6172 plasmid pMF6172, complete sequence	0 crisprs	csa3,cas5	0	0	1	0
NZ_CP025440	Listeria monocytogenes strain MF6172 chromosome, complete genome	4 crisprs	DinG,cas3,WYL,casR,DEDDh,csa3	0	1	7	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2698 : 56802

Streptococcus_phage(20.83%)

transposase,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023553716.1\|2698_3286_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.5e-33	41.7
WP_003755398.1\|3377_4175_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	3.3e-81	63.2
WP_003728496.1\|4143_5370_-\|transposase	IS21 family transposase	A0A059NT83	Lactococcus_phage	4.7e-135	60.6
WP_013315183.1\|5581_5698_+	hypothetical protein	NA	NA	NA	NA
WP_003728495.1\|5713_5950_+	hypothetical protein	NA	NA	NA	NA
WP_003731844.1\|5912_6302_+	hypothetical protein	NA	NA	NA	NA
WP_003728493.1\|6304_7222_+	hypothetical protein	NA	NA	NA	NA
WP_003728492.1\|7619_7859_+	hypothetical protein	NA	NA	NA	NA
WP_003728491.1\|7870_8311_+	hypothetical protein	NA	NA	NA	NA
WP_003728490.1\|8303_9644_+	hypothetical protein	NA	NA	NA	NA
WP_003728489.1\|9654_10026_+	hypothetical protein	NA	NA	NA	NA
WP_012952172.1\|10045_10810_+	Fic family protein	A0A0G3Y4Q5	Ostreid_herpesvirus	2.6e-06	29.4
WP_003728487.1\|10923_11454_+	hypothetical protein	NA	NA	NA	NA
WP_003728486.1\|11490_11826_-	helix-turn-helix transcriptional regulator	A0A139ZPK3	Marinitoga_camini_virus	2.8e-05	35.0
WP_011011011.1\|11999_12398_+	hypothetical protein	NA	NA	NA	NA
WP_012952173.1\|13110_13455_+	TnpV protein	NA	NA	NA	NA
WP_072235488.1\|13496_13904_+	hypothetical protein	H2DE57	Erwinia_phage	1.4e-11	46.0
WP_002389568.1\|14469_15150_-\|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	2.6e-119	90.7
WP_003728481.1\|15773_17138_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.9e-07	23.5
WP_003728480.1\|17383_18253_-	glycine betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_003728477.1\|19123_19888_+\|transposase	transposase	NA	NA	NA	NA
WP_003728476.1\|20350_22234_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	5.6e-87	35.3
WP_043993356.1\|22353_22995_-\|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	3.0e-101	83.6
WP_003728474.1\|23479_25333_-	ATP-binding protein	NA	NA	NA	NA
WP_003728473.1\|25325_26537_-	hypothetical protein	NA	NA	NA	NA
WP_003728472.1\|26787_27351_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	2.0e-40	51.1
WP_031644250.1\|27924_28290_+	DUF3221 domain-containing protein	NA	NA	NA	NA
WP_031641532.1\|28310_29609_+	hypothetical protein	NA	NA	NA	NA
WP_003725288.1\|30008_30365_-	glyoxalase	NA	NA	NA	NA
WP_009917198.1\|31290_31635_-	quaternary ammonium compound efflux SMR transporter BcrC	NA	NA	NA	NA
WP_003725293.1\|31652_31970_-	quaternary ammonium compound efflux SMR transporter BcrB	NA	NA	NA	NA
WP_003725294.1\|31981_32521_-	efflux transporter transcriptional regulator BcrA	NA	NA	NA	NA
WP_031644247.1\|32961_33201_+	hypothetical protein	NA	NA	NA	NA
WP_003728469.1\|35274_38190_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.9e-174	36.7
WP_003728468.1\|38193_38748_-	recombinase family protein	A0A0F7LA37	Escherichia_phage	7.0e-38	53.4
WP_003728467.1\|39027_39387_+	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	3.1e-26	50.0
WP_003728466.1\|39386_41522_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.6e-247	64.5
WP_003728465.1\|41714_42056_-	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_003728464.1\|42049_42292_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_003728463.1\|42352_42604_-	hypothetical protein	NA	NA	NA	NA
WP_003728462.1\|42734_43061_+	hypothetical protein	A0A2K9V3N4	Faecalibacterium_phage	3.2e-06	40.8
WP_003731676.1\|43060_43723_+	DUF2786 domain-containing protein	NA	NA	NA	NA
WP_003728521.1\|43735_44119_+	DUF3850 domain-containing protein	C9E2N9	Enterococcus_phage	2.2e-14	53.4
WP_003728520.1\|44277_44766_+	hypothetical protein	NA	NA	NA	NA
WP_003728519.1\|44887_45136_+	hypothetical protein	NA	NA	NA	NA
WP_003728518.1\|45136_45562_+	hypothetical protein	NA	NA	NA	NA
WP_003728517.1\|45565_46288_+	CRISPR-associated protein Cas5	NA	NA	NA	NA
WP_003731678.1\|46303_47020_+	AP2 domain-containing protein	O03945	Lactobacillus_phage	3.8e-20	31.0
WP_003728514.1\|47993_48248_-\|transposase	transposase	Q6J1X3	Lactobacillus_phage	1.6e-13	46.4
WP_003728514.1\|48622_48877_+\|transposase	transposase	Q6J1X3	Lactobacillus_phage	1.6e-13	46.4
WP_115914824.1\|48873_49761_+\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	7.3e-69	51.1
WP_003728513.1\|50031_51798_+	hypothetical protein	NA	NA	NA	NA
WP_003728512.1\|51809_52550_+	hypothetical protein	NA	NA	NA	NA
WP_003728511.1\|52837_53446_+	recombinase family protein	A0A1W5LU24	Ralstonia_phage	1.0e-21	42.9
WP_003728510.1\|53435_53663_+	hypothetical protein	NA	NA	NA	NA
WP_003731679.1\|53782_54061_-	hypothetical protein	NA	NA	NA	NA
WP_003728509.1\|54023_54260_+	helix-turn-helix transcriptional regulator	A0A097PBE6	Streptococcus_pyogenes_phage	6.7e-14	53.4
WP_003728507.1\|54687_56802_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	3.4e-117	39.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP025440

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP025440_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025440_1

210296-210447

Unclear

Consensus_repeat	Method
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTC	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP025440_1

>merge|NZ_CP025440|1|210296-210447|CRISPRCasFinder
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTCATTCGAATTTCCACCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGACGCCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCGGAACCGAGCTC

>NZ_CP025440|1|1|210296-210447|CRISPRCasFinder
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTC	ATTCGAATTTCCACCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGACG
CCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCGGAACCGAGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025440.1\|WP_003722742.1\|217107_217668_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP025440.1\|WP_010989376.1\|217782_221322_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_CP025440.1\|WP_003722736.1\|212806_213268_+\|YehR-family-lipoprotein	unknown	unknown	gnl\|CDD\|227145
NZ_CP025440.1\|WP_009931069.1\|198183_199392_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|182528
NZ_CP025440.1\|WP_009930501.1\|216416_217001_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP025440.1\|WP_003722726.1\|200504_200813_+\|septation-protein-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_CP025440.1\|WP_003722739.1\|214468_215410_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NZ_CP025440.1\|WP_003722725.1\|200076_200385_+\|septation-protein-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_CP025440.1\|WP_009930499.1\|213717_214392_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033
NZ_CP025440.1\|WP_003725735.1\|213318_213651_-\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_CP025440.1\|WP_003722723.1\|197494_198187_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP025440.1\|WP_009924872.1\|212348_212672_+\|DUF5502-family-protein	unknown	unknown	gnl\|CDD\|340321
NZ_CP025440.1\|WP_003722731.1\|205801_207391_+\|cholesterol-dependent-cytolysin-listeriolysin-O	unknown	unknown	gnl\|CDD\|366559
NZ_CP025440.1\|WP_003722728.1\|202623_203580_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP025440.1\|WP_003722740.1\|215703_216327_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_CP025440.1\|WP_009931068.1\|201199_202573_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184643
NZ_CP025440.1\|WP_003722729.1\|203622_204336_-\|listeriolysin-transcriptional-regulator-PrfA	unknown	unknown	gnl\|CDD\|223736
NZ_CP025440.1\|WP_003733144.1\|204606_205560_-\|phosphatidylinositol-specific-phospholipase-C	unknown	unknown	gnl\|CDD\|176497
NZ_CP025440.1\|WP_010989373.1\|207721_209254_+\|zinc-metalloproteinase-Mpl	unknown	unknown	gnl\|CDD\|225768
NZ_CP025440.1\|WP_010989375.1\|211407_212277_+\|phosphatidylcholine-phospholipase-C	unknown	unknown	gnl\|CDD\|214813

Protein	Function_ID	Function_description	E-value
NZ_CP025440.1\|WP_003722742.1\|217107_217668_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	4.98809e-109
NZ_CP025440.1\|WP_010989376.1\|217782_221322_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_CP025440.1\|WP_003722736.1\|212806_213268_+\|YehR-family-lipoprotein	gnl\|CDD\|227145	COG4808, COG4808, Uncharacterized protein conserved in bacteria [Function unknown].	5.22035e-59
NZ_CP025440.1\|WP_009931069.1\|198183_199392_+\|FtsX-like-permease-family-protein	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	2.47504e-62
NZ_CP025440.1\|WP_009930501.1\|216416_217001_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.52035e-10
NZ_CP025440.1\|WP_003722726.1\|200504_200813_+\|septation-protein-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	5.03804e-54
NZ_CP025440.1\|WP_003722739.1\|214468_215410_-\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NZ_CP025440.1\|WP_003722725.1\|200076_200385_+\|septation-protein-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	2.92652e-53
NZ_CP025440.1\|WP_009930499.1\|213717_214392_-\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	1.81561e-21
NZ_CP025440.1\|WP_003725735.1\|213318_213651_-\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	8.98192e-61
NZ_CP025440.1\|WP_003722723.1\|197494_198187_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.27113e-121
NZ_CP025440.1\|WP_009924872.1\|212348_212672_+\|DUF5502-family-protein	gnl\|CDD\|340321	pfam17606, DUF5502, Family of unknown function (DUF5502). This is a family of unknown function found in Listeria.	9.06348e-49
NZ_CP025440.1\|WP_003722731.1\|205801_207391_+\|cholesterol-dependent-cytolysin-listeriolysin-O	gnl\|CDD\|366559	pfam01289, Thiol_cytolysin, Thiol-activated cytolysin.	1.50399e-178
NZ_CP025440.1\|WP_003722728.1\|202623_203580_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NZ_CP025440.1\|WP_003722740.1\|215703_216327_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.38585e-63
NZ_CP025440.1\|WP_009931068.1\|201199_202573_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_CP025440.1\|WP_003722729.1\|203622_204336_-\|listeriolysin-transcriptional-regulator-PrfA	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.59942e-12
NZ_CP025440.1\|WP_003733144.1\|204606_205560_-\|phosphatidylinositol-specific-phospholipase-C	gnl\|CDD\|176497	cd00137, PI-PLCc, Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C. This subfamily corresponds to the catalytic domain present in prokaryotic and eukaryotic phosphoinositide-specific phospholipase C (PI-PLC), which is a ubiquitous enzyme catalyzing the cleavage of the sn3-phosphodiester bond in the membrane phosphoinositides (phosphatidylinositol, PI; Phosphatidylinositol-4-phosphate, PIP; phosphatidylinositol 4,5-bisphosphate, PIP2) to yield inositol phosphates (inositol monosphosphate, InsP; inositol diphosphate, InsP2; inositol trisphosphate, InsP3) and diacylglycerol (DAG). The higher eukaryotic PI-PLCs (EC 3.1.4.11) have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. They play a critical role in most signal transduction pathways, controlling numerous cellular events, such as cell growth, proliferation, excitation and secretion. These PI-PLCs strictly require Ca2+ for their catalytic activity. They display a clear preference towards the hydrolysis of the more highly phosphorylated PI-analogues, PIP2 and PIP, to generate two important second messengers, InsP3 and DAG. InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. In contrast, bacterial PI-PLCs contain a single catalytic domain. Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. They participate in Ca2+-independent PI metabolism. They are characterized as phosphatidylinositol-specific phospholipase C (EC 4.6.1.13) that selectively hydrolyze PI, not PIP or PIP2. The TIM-barrel type catalytic domain in bacterial PI-PLCs is very similar to the one in eukaryotic PI-PLCs, in which the catalytic domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. The catalytic mechanism of both prokaryotic and eukaryotic PI-PLCs is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This superfamily also includes a distinctly different type of eukaryotic PLC, glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC), an integral membrane protein characterized in the protozoan parasite Trypanosoma brucei. T. brucei GPI-PLC hydrolyzes the GPI-anchor on the variant specific glycoprotein (VSG), releasing dimyristyl glycerol (DMG), which may facilitate the evasion of the protozoan to the host#s immune system. It does not require Ca2+ for its activity and is more closely related to bacterial PI-PLCs, but not mammalian PI-PLCs.	8.10719e-115
NZ_CP025440.1\|WP_010989373.1\|207721_209254_+\|zinc-metalloproteinase-Mpl	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	7.98048e-139
NZ_CP025440.1\|WP_010989375.1\|211407_212277_+\|phosphatidylcholine-phospholipase-C	gnl\|CDD\|214813	smart00770, Zn_dep_PLPC, Zinc dependent phospholipase C (alpha toxin). This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.	4.70099e-87

>NZ_CP025440.1|WP_010989373.1|207721_209254_+|zinc-metalloproteinase-Mpl
MKSKLICIIMVIAFQAHFTMTVKADSVGEEKLQNNTQAKKTPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYVGNPVKEKEIILNSRTKRLVYNIKLIFAEPEVASWIVQVDVETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLKHNTDTSFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGQEILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPLTEEGDWGGVHYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
>NZ_CP025440.1|WP_003722731.1|205801_207391_+|cholesterol-dependent-cytolysin-listeriolysin-O
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
>NZ_CP025440.1|WP_003733144.1|204606_205560_-|phosphatidylinositol-specific-phospholipase-C
MYKNYLQRTLVLLLCFILYFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDITWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLNIYHGPIFLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKFN
>NZ_CP025440.1|WP_003722729.1|203622_204336_-|listeriolysin-transcriptional-regulator-PrfA
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
>NZ_CP025440.1|WP_003722728.1|202623_203580_+|ribose-phosphate-diphosphokinase
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
>NZ_CP025440.1|WP_009931068.1|201199_202573_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQDEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASKLMQRRINENHMRNGVTLVNPESTYIDIDVKIGQDTVIEPGVMLRGKTVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQDNKLGYAKHLNHSK
>NZ_CP025440.1|WP_003722726.1|200504_200813_+|septation-protein-SpoVG
MQVTDVRLRRVETDGRMRAIASITLDEEFVVHDIRVIDGNNGLFVAMPSKRGVDGEFRDIAHPINSDTRAKIQEVVLAEYERVGEEEATAVTEEESESVSAE
>NZ_CP025440.1|WP_003722725.1|200076_200385_+|septation-protein-SpoVG
MEITDVRLRRVETDGRMKAISSITIDGEFVIHDIRVIDGNEGLFVAMPSKRTPDGEFRDIAHPINSGTRAKIQEAVLAAYEVADEPAVNEESSADESIVEEN
>NZ_CP025440.1|WP_009931069.1|198183_199392_+|FtsX-like-permease-family-protein
MNVLQSMKMAWKQLKASKLRSFLTMLGIIIGVASVILLVSLGNGVTQEVDDQMGDLGSNLITVVNSSVNPNDKYTYDEVMKYQNIDGVKSVSPELSGQVNATFDYKNSSNKVIGTNDQYKAARSLEMKEGRFLLPIDTEYGQKVAVIGSTVASDLFGFGDPIGETIRLNGMPYKVVGVLKEKGASMMGSSDDQIFIPISSAQRLLKDTNVRTIYVETKSAEDVDFVVNTLESRLAIKFGDEKEQEKNASSAQMGPSYQVINQQEILNAFNTISTTLTTALGAIAAISLVVGGIGIMNIMLVSVSERTREIGIRKALGAKKRAILLQFLIESIVISVCGGVIGIIIGVSGALIFGSVAGISSGITAGTIIFSFVFSLCIGVIFGIAPANKASKLRPIDALRSE
>NZ_CP025440.1|WP_003722723.1|197494_198187_+|ABC-transporter-ATP-binding-protein
MPKPLIDMKNLTKTYTLGGETFKALDDVTFTVEQGEFLSIVGPSGSGKSTLMNMIGCLDVPDEGSYHLDDVDVFKLSDNKLSEIRNKKIGFIFQQFNLLPKLSAFENVELPLIYAGLSVSAREKAAIECLEKVGLLEKRRNLPTQLSGGQQQRVAIARALAGKPQILLADEPTGALDSKTGKEVMGILQELNRAGNTIVMITHDPTIASYGTRSIRIQDGKLFHEEATQA
>NZ_CP025440.1|WP_010989375.1|211407_212277_+|phosphatidylcholine-phospholipase-C
MKFKKVVLGMCLIASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFLEFWSKKTNE
>NZ_CP025440.1|WP_009924872.1|212348_212672_+|DUF5502-family-protein
MYIKGRLIFFFVVLVIALCSVLILLIIKISVWKDEPFHLSDAKEIECLGSCEIKNTNQKIHFFSIKENLFEEKGDIAGILNEDEQKVADKSIFIVILDDEKGIANEE
>NZ_CP025440.1|WP_003722736.1|212806_213268_+|YehR-family-lipoprotein
MKMLKKGTAVLFVMIMAVMLVACGDKEETKTYTLSQNGVDSKLTYTYKGDKVTKQTAENTMSYASLGVASKEDAEKMLKATSDKFQGIDGLKEKIEYKDDKAIETLEVDYTKISSEDMNKIPGMSSNGDTSKGISMEESAKMLESQGYKEVSK
>NZ_CP025440.1|WP_003725735.1|213318_213651_-|putative-heavy-metal-binding-protein
MIVTTSPNIEGKQIIEYKKIVFGEVITGVNFMKDIGAGLRNFFGGRSQGYEDELINAREEAIREMEQRAKDIGANAVIGVDIDYEVLGADNGMLMVTASGTAVVIEAQDY
>NZ_CP025440.1|WP_009930499.1|213717_214392_-|DNA-alkylation-repair-protein
MITFDQLDTELQALENPNTIKIFRNHGCPDSLDLYGLKIGDLKKIIRREKLTKNHELAVKLIESNNSDLIYLGLLAINPNKITTEQIEKWNIAFRETWSQLTFGLASIVSKRDDALLFAKTWIESDYDLTKSMGWQIYSEHINNLPEAETLLQRAKETLQTETNRTRYSMNGFIITCGIYKDDLHEKAMEAAKSVGKVHVNLGNTACKVPDAISYIEKARNRTK
>NZ_CP025440.1|WP_003722739.1|214468_215410_-|L-lactate-dehydrogenase
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
>NZ_CP025440.1|WP_003722740.1|215703_216327_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MATTLEVQKRETTQHSEVTRLRSEGKVPGIIYGYKSENVPVSVDSLELIKAVRDNGRNAVFSVTVDGKKLNVLLHEYQVDPLKDVLVHVDLLAVDMNEEVETDVRVVLVGDAPGVKAGGVLQQIIHDVKVSATPEKLPETIELDISSLEIGDVLTTNDLPENKDYVVQAEEEETVVTVSAPRAEEEPTTTEAPEPEAVHGKDEEPVE
>NZ_CP025440.1|WP_009930501.1|216416_217001_+|GNAT-family-N-acetyltransferase
MLDKSVPHISVIMVNHDATNYPEFHLPAGYSFCFYKDGLEEDWCRLQLETGQVLSMDSIRARFETEFGNEKEKLTKRCIFVKAPNGEIIGTAMLWDGNTFGKIESRIHWVAVLDSHGGKGIAKALLSKILGLNKSKFVYLTTQTGSYQAIYLYRKFGFEKYVGKTPENWKTVNFQEEKETAWQIIENKIAEHQA
>NZ_CP025440.1|WP_003722742.1|217107_217668_+|aminoacyl-tRNA-hydrolase
MKLIAGLGNPGKKYERTRHNVGFMVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVINYVLGDFPKAEQPDIIAAIQKSADAIEDFAQTPFIEVMNKYNQK
>NZ_CP025440.1|WP_010989376.1|217782_221322_+|transcription-repair-coupling-factor
MKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMMLTLNELKEQEDKQALIENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYLPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEGNHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAFSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVRALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKEKASTEN

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Crispr_ID: NZ_CP025440_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025440_2

497574-498158

Orphan

Consensus_repeat	Method
GATGTAAGTNATTTTGATACNAGTTCAGTAACTNATATG	CRT

7 spacers

The CRISPR arrays of NZ_CP025440_2

>merge|NZ_CP025440|2|497574-498158|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATGTGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTGGATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATGTCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTGGATGTAAGCAACCTTGATACCAGTTCAGTAACTAATATGTATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTGGATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTAGATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTGGATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTAGATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATGGCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTTGATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

>NZ_CP025440|2|1|497574-498158|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATG	TGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTG
GATGTAAGTCATTTTGATACAAGTTCAGTAACTAATATG	TCTTACATGTTTTATGATAATAGAAATCTTGAGGTGCTG
GATGTAAGCAACCTTGATACCAGTTCAGTAACTAATATG	TATGCCATGTTTGAAGATTGTACTAGTCTTGAAGAGCTG
GATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATG	TATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTA
GATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATG	GTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTG
GATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATG	CGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTA
GATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATG	GCTGCCATGTTTTCTGATAATGAAAAAGTGGAGAAGCTT
GATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025440.1\|WP_009932193.1\|503419_503743_+\|AP2-domain-containing-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_010989475.1\|488650_490246_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_CP025440.1\|WP_010989473.1\|486394_487543_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP025440.1\|WP_003721244.1\|490379_491663_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NZ_CP025440.1\|WP_009930717.1\|483365_484121_-\|DUF4866-family-protein	unknown	unknown	gnl\|CDD\|379782
NZ_CP025440.1\|WP_009931585.1\|499051_499525_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_072217966.1\|504051_504969_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379523
NZ_CP025440.1\|WP_010989474.1\|487547_488495_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP025440.1\|WP_010989476.1\|492756_494307_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_CP025440.1\|WP_009930718.1\|484238_486398_-\|transglutaminase	unknown	unknown	gnl\|CDD\|376628
NZ_CP025440.1\|WP_009932195.1\|501644_503375_+\|DUF4365-domain-containing-protein	unknown	unknown	gnl\|CDD\|379535
NZ_CP025440.1\|WP_003721245.1\|491663_492764_+\|DUF917-domain-containing-protein	unknown	unknown	gnl\|CDD\|226065
NZ_CP025440.1\|WP_003721255.1\|500438_500705_+\|transposase	unknown	unknown	unknown
NZ_CP025440.1\|WP_010989479.1\|501169_501406_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_003733941.1\|500057_500363_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_CP025440.1\|WP_014601344.1\|500943_501108_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_010989480.1\|503717_504023_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_014601342.1\|495126_496665_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NZ_CP025440.1\|WP_009931584.1\|499544_500030_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_010989471.1\|482679_483345_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|226146

Protein	Function_ID	Function_description	E-value
NZ_CP025440.1\|WP_010989475.1\|488650_490246_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.08474e-59
NZ_CP025440.1\|WP_010989473.1\|486394_487543_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	2.48336e-53
NZ_CP025440.1\|WP_003721244.1\|490379_491663_+\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	6.12636e-95
NZ_CP025440.1\|WP_009930717.1\|483365_484121_-\|DUF4866-family-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	3.03926e-122
NZ_CP025440.1\|WP_072217966.1\|504051_504969_+\|hypothetical-protein	gnl\|CDD\|379523	pfam14253, AbiH, Bacteriophage abortive infection AbiH. This family of proteins confers resistance to bacteriophage.	0.00778454
NZ_CP025440.1\|WP_010989474.1\|487547_488495_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.51988e-102
NZ_CP025440.1\|WP_010989476.1\|492756_494307_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.31898e-105
NZ_CP025440.1\|WP_009930718.1\|484238_486398_-\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	5.52486e-28
NZ_CP025440.1\|WP_009932195.1\|501644_503375_+\|DUF4365-domain-containing-protein	gnl\|CDD\|379535	pfam14280, DUF4365, Domain of unknown function (DUF4365). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.	5.7395e-10
NZ_CP025440.1\|WP_003721245.1\|491663_492764_+\|DUF917-domain-containing-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NZ_CP025440.1\|WP_003733941.1\|500057_500363_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	4.04229e-05
NZ_CP025440.1\|WP_014601342.1\|495126_496665_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	1.11775e-19
NZ_CP025440.1\|WP_010989471.1\|482679_483345_-\|DUF1275-domain-containing-protein	gnl\|CDD\|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	6.55182e-68

>NZ_CP025440.1|WP_014601342.1|495126_496665_+|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELRERNLSISTGNQVEITGDEFSLRIFYAFLFLVTYSGDRWPFSFVQYDEITDLLESCPKEIYRANSIDKGMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEITYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASERVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINKFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMRLLKPFEERLASDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIVYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NZ_CP025440.1|WP_010989476.1|492756_494307_+|hydantoinase/oxoprolinase-family-protein
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIEHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGMAEIGNPELVAHIPTDFAEKAYKKIADMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NZ_CP025440.1|WP_003721245.1|491663_492764_+|DUF917-domain-containing-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTNSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NZ_CP025440.1|WP_003721244.1|490379_491663_+|cytosine-permease
MTEKKTVEQAQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVVFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPILLFVCIYGLVVSLNNGGLAVVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMIAVGAILALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAIAGGLGTVLAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVPGVNWLGVTSWLVGAVIAGIPVILTFFPALPQLPNQPLIGIILSLAVYLVGAKVLSGKTNNVENLEGK
>NZ_CP025440.1|WP_010989475.1|488650_490246_+|PucR-family-transcriptional-regulator
MSVKLADLMKLPSLKEAKVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIRDDVEAQCRTIERLHKVGEVALILYYVGIFVPKMDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHSSLVLTDNSFQVINSITWPRTRHWDFERVIETSKQIDEHELVQLHLDERDFYTARKPIFQDGMQAMHLFMMKEKGALTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRNNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVGQRDRTHTANEFAMMMKEHGIDLKITVCQGMEQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKSLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRLLGGNNNNK
>NZ_CP025440.1|WP_010989474.1|487547_488495_-|MoxR-family-ATPase
MSIEPSIKINEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTKQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NZ_CP025440.1|WP_010989473.1|486394_487543_-|DUF58-domain-containing-protein
MLKKRLLLASRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRSFVKNTYHDGDLIDMQVSFTRKSRYPVGYLLFQQKIPATFGKVRARQQVVYPLFKKQFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPNVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEENGEIRVTLLGDQTSKFAPAKGTSRLQDISTAFAEIAPVDSLTLQESLDSNLHSGEKILLFTPCMDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEQASLLSRWERETK
>NZ_CP025440.1|WP_009930718.1|484238_486398_-|transglutaminase
MKRYLTLVMLFILSVLLISEWIYPFAELTELSTATWIILFITLSLGSFFLRLKYYWTIPLHVVMIIIVSGIYYAKGGILAGNWLGSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRIMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIATPNRISADSLKRNGLFYHGFVILLLAVFVFSSLMLPKKAPIFPDPIPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTAQAEKGHYWRVESKTVYTGTGWANANSGDVISFSSGDNFPIQLTEQTTGATNTAEISFASSSDYMPYPYGTQAVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNAFVSQYTQTPKDLPDRVTKLANKVTKDADSIYDKTKAIESYLSTSGTFTYSTDDAKETPMGADYVDQFLFETQIGYCDNFSTSMVVMLRSLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTPDKTPEQDNGSSSTGETPKKEEPKTETATSNVEIPSWVWWIPAGLVVALLALAIVFRRRIRGYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSARVDADLTTSEFSRLTKMYETQLYSKNLTEKVIAAEETQLVQQIIARLTK
>NZ_CP025440.1|WP_009930717.1|483365_484121_-|DUF4866-family-protein
MTTIFPKEQNVTPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIVHSYEPDFSISTKRINKKRGILVLYSLPDTLKSGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK
>NZ_CP025440.1|WP_010989471.1|482679_483345_-|DUF1275-domain-containing-protein
MARTRQISESIGLGLLLALAGGFMDAYSYIERGQVFANAQTGNILLFGINISEGNWAIAIQYFWPVVSFTVGIALSEVIHRRDIRRLHWRQLSVLIEAVILIGVAFIPLDHNLIANSLISFVCGIQVESFRKMHGRGVATTMCIGNLRSATQNLCDYFEYKEKQYLHNSFLYFSVILSFIIGAVVGNFFIQLFAQYAILVCAFLQLIAFMMMFIDRESKII
>NZ_CP025440.1|WP_009931585.1|499051_499525_+|hypothetical-protein
MKKKKVVVISLLLLLVSVIGISSYFLFKDKINLLDVDPSAVEWNGKKQKDTSGEENTIAIPGFEKVTLYANETKQAVNFHNPEINDCYFKISLIHPDGSVLWRSDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NZ_CP025440.1|WP_009931584.1|499544_500030_+|hypothetical-protein
MNKLVLSTLSVAAMGMVIFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELERVGATSDVITSSFKSNNSTVTMANPVIGSFSGYAIEETEVSKIQIGSPQGDKKAGAYQTTLTFTAAFK
>NZ_CP025440.1|WP_003733941.1|500057_500363_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQHMLPKAGDTVTNYTLLGLVLVLIWLIMQRKRKKKE
>NZ_CP025440.1|WP_003721255.1|500438_500705_+|transposase
MARIEYGEEIQKSLLVLYSRGSTIDSICKEYGIPRYEFHKWMKLHDADKLETKEVKTLLQIRELKQQKNKLEEEILFLNEAINLLESP
>NZ_CP025440.1|WP_014601344.1|500943_501108_+|hypothetical-protein
MYVESKEELEKIIYQQLINNINVKPDPWKWEERNALIVEIEVKAVLEKYGSTPI
>NZ_CP025440.1|WP_010989479.1|501169_501406_-|hypothetical-protein
MSLKKILESDESIEKKEQQIDSYYQSELITRVEACELLDVSTKSLDRYIKQNKLSFQLNSLLIPHFCLIVLLMPLAIL
>NZ_CP025440.1|WP_009932195.1|501644_503375_+|DUF4365-domain-containing-protein
MVKYTNPKIEKLGVNAVSNYIVESDYLSDFLAQQSTEPATDGTIRIYNGPGERKRDLIGIVPVQVKGTTTKNIIKYNRHEIDIVDLTYYYKVGGVVYFVVYVTNKVPKIYYRDLLRIDIKEILKKNEKLRGKKEKGTITIDFREVPVNVEDFRTVLLNFHKDQDYQTKDYVELGSINEISRDLTFTIIAPNSNIVEALKYVSPVLYKNEGDLKIPVRRFKIGELSVFTKSEFSIGIKGANSYIATVMEGEEETEIQIGSLQQLIVKFKEGRFKVDFEAKGKIQETIELLEILLGIVTGVNLYIDNKPVTEFFIEEVNEDFISRVNHALESFKKTQEALNHCKVPSNFHYEELTENDIDVINSIMELYQTSIDNTWGKFEFNNRLVYLLKHKGTIYNLLDSNVALEINFWSKREDGIQYTTTPLILIDDFSKMNDTEICNIKGPIEKLIPIHEKACSDINLICVRLIDAYDQTNNNQFLLVAFELLELIIPFTTNNEIHLIYLNKYQIKKRWDNLVMEDINHLVSIQKEFEEDKRIHLATLILLSAKNDAAQLLSELKNNEGFSLEDMPILNLLEKN
>NZ_CP025440.1|WP_009932193.1|503419_503743_+|AP2-domain-containing-protein
MYQKASEKMKETMKANIALVESIRISSISNKKLQSDNKSGHTVVTFKDNKWVARICVSGVEHQLGSFVTKEEAIDARIEGEKYFQPLINKYNNRLDVFYSERRPFWT
>NZ_CP025440.1|WP_010989480.1|503717_504023_+|hypothetical-protein
MNVDPFGRKVELMIIGNGLDVKANLASTFVDYYKHRCKLMRLEYNEDDFYRLKSKNYFPMKVKMQQFPSIRRCNIEILSIDAETAINENITFWDLVLFFCL
>NZ_CP025440.1|WP_072217966.1|504051_504969_+|hypothetical-protein
MESKIERVLNKLGGYLSDPINIILNNCGFGENLEDEQENDLYNLMEERLEEKDKYVLSVAFIHKLNSYSNCSLEEFLMLELNKYEKYFSDYIKTEVTNKYEEYHKTRNNILTKLSGGLGATHSISVMNFNFTPNQFSDSVKLNEKIGLAHVNVHGSYLANSIFGIDTKSLEDIDTIGSGYRFTKTYRKLTLKTKRSTEILYHDITDIIFYGHSLGQADYAYFQSIFDYLDIYNNTIVLTFYYSDYKENVREEQTIAVRNLIEEYGKTFDNKHKGKNLLHKLLLEERISVTDLEIYEEDYSSKDMK

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Crispr_ID: NZ_CP025440_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025440_3

543123-543411

Orphan

I-A

Consensus_repeat	Method
GTTTTAGTTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRT

4 spacers

The CRISPR arrays of NZ_CP025440_3

>merge|NZ_CP025440|3|543123-543411|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTTACTTATTGTGAAATGTAAATCGATAAAAAAGATATTAGTAATTTATTTGCAATTTAGTTTTAGTTACTTATTGTGAAATGTAAATTGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGCGTTTTAGTTACTTATTGTGAAATGTAAATGCGATTTTTGTCAAAGGGACAGCGATGGGTTACAAGTTTTAGTTACTTATTGTGAAATGTAAATTTACCACCAAAGTCCCTACACTCAATACCACCAAAGCGTTTTAGTTACTTATTGTGAAATATAAAT

>NZ_CP025440|3|1|543123-543411|PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

>NZ_CP025440|3|2|543123-543411|CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

>NZ_CP025440|3|2|543123-543411|CRT
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025440.1\|WP_003721294.1\|540538_541810_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP025440.1\|WP_010989496.1\|533498_534167_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_CP025440.1\|WP_010989497.1\|534173_534824_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NZ_CP025440.1\|WP_003721291.1\|538521_539172_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_CP025440.1\|WP_003721298.1\|545061_545421_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131113
NZ_CP025440.1\|WP_003721290.1\|538112_538511_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_010989501.1\|548663_550094_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_CP025440.1\|WP_009930756.1\|539168_540215_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP025440.1\|WP_003721293.1\|540230_540524_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP025440.1\|WP_003721303.1\|550214_551030_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP025440.1\|WP_009932856.1\|545427_545886_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
NZ_CP025440.1\|WP_003733192.1\|536998_537601_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NZ_CP025440.1\|WP_010989500.1\|546267_548085_+\|lmo0514-family-class-1-internalin	unknown	unknown	gnl\|CDD\|380190
NZ_CP025440.1\|WP_003721301.1\|548185_548617_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP025440.1\|WP_010989499.1\|544356_545037_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP025440.1\|WP_003727296.1\|551310_551679_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_CP025440.1\|WP_009931218.1\|551825_553241_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP025440.1\|WP_003733190.1\|541949_542885_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP025440.1\|WP_009930754.1\|543670_544249_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_003733191.1\|537628_538096_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129

Protein	Function_ID	Function_description	E-value
NZ_CP025440.1\|WP_003721294.1\|540538_541810_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178
NZ_CP025440.1\|WP_010989496.1\|533498_534167_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	9.1314e-90
NZ_CP025440.1\|WP_010989497.1\|534173_534824_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	5.85703e-62
NZ_CP025440.1\|WP_003721291.1\|538521_539172_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	4.74405e-108
NZ_CP025440.1\|WP_003721298.1\|545061_545421_-\|hypothetical-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	5.62162e-67
NZ_CP025440.1\|WP_009931218.1\|551825_553241_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.18163e-80
NZ_CP025440.1\|WP_010989501.1\|548663_550094_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	2.95496e-100
NZ_CP025440.1\|WP_009930756.1\|539168_540215_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NZ_CP025440.1\|WP_003721293.1\|540230_540524_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NZ_CP025440.1\|WP_003721303.1\|550214_551030_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_CP025440.1\|WP_009932856.1\|545427_545886_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	9.15558e-13
NZ_CP025440.1\|WP_003733192.1\|536998_537601_+\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	1.15952e-75
NZ_CP025440.1\|WP_010989500.1\|546267_548085_+\|lmo0514-family-class-1-internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.81836e-118
NZ_CP025440.1\|WP_003721301.1\|548185_548617_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NZ_CP025440.1\|WP_010989499.1\|544356_545037_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	9.06055e-60
NZ_CP025440.1\|WP_003727296.1\|551310_551679_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	2.33548e-41
NZ_CP025440.1\|WP_003733190.1\|541949_542885_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	1.26262e-153
NZ_CP025440.1\|WP_003733191.1\|537628_538096_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.76446e-37

>NZ_CP025440.1|WP_003733190.1|541949_542885_+|ribose-phosphate-pyrophosphokinase
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSNIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>NZ_CP025440.1|WP_003721294.1|540538_541810_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NZ_CP025440.1|WP_003721293.1|540230_540524_+|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NZ_CP025440.1|WP_009930756.1|539168_540215_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPNELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
>NZ_CP025440.1|WP_003721291.1|538521_539172_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNDELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>NZ_CP025440.1|WP_003721290.1|538112_538511_+|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NZ_CP025440.1|WP_003733191.1|537628_538096_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQNKEKLLAEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>NZ_CP025440.1|WP_003733192.1|536998_537601_+|SIS-domain-containing-protein
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVEKIAECTGKIVVAGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NZ_CP025440.1|WP_010989497.1|534173_534824_+|transaldolase
MHLDSANLDDVKKIQASSIFKGITTNPTILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALAGADFVAPYVNRMSAANIDPFKEITQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYSQMTNKVLAVEAIRVFNEDAVLYEK
>NZ_CP025440.1|WP_010989496.1|533498_534167_+|ribulose-phosphate-3-epimerase
MKMIAASIMCADSLHLADELRALEQANVKMLHCDVMDGVFVENAAMGAYVLQDIKNNTKMLLDIHLATVNPDKFVDLYAAIKPAYMSFHLEASRDVNATINHIRELGIRPSIAISPDTEIEQIYPFLGKVDMVLMMTVNPGFAGQKFQHHVLEKIKKLQKELESHTNKPLIEVDGNIFEETVRLLEPIGADVYVVGTAALFNEKAGSYTEKLAPLREIIQER
>NZ_CP025440.1|WP_009930754.1|543670_544249_+|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTITIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFNILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>NZ_CP025440.1|WP_010989499.1|544356_545037_+|type-1-glutamine-amidotransferase
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPKSLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>NZ_CP025440.1|WP_003721298.1|545061_545421_-|hypothetical-protein
MEQILFIQTGFGVDVHGQNITKAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>NZ_CP025440.1|WP_009932856.1|545427_545886_-|MarR-family-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTSAGKELENELGAAQRKQMSEIFTNSADTDGMHFTEVMEGYAKNRPGAAFIKDFKE
>NZ_CP025440.1|WP_010989500.1|546267_548085_+|lmo0514-family-class-1-internalin
MKKALKLFLATICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSSRLSITDDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVDPVPPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NZ_CP025440.1|WP_003721301.1|548185_548617_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CP025440.1|WP_010989501.1|548663_550094_-|CapA-family-protein
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPIKKISPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKADEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTIINAESAFTNATKAENKMWRIKSDPAHVAFLPASGVDAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NZ_CP025440.1|WP_003721303.1|550214_551030_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_CP025440.1|WP_003727296.1|551310_551679_-|DUF1304-domain-containing-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGFAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVAVLLV
>NZ_CP025440.1|WP_009931218.1|551825_553241_+|multidrug-efflux-MFS-transporter
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGIALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK

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Crispr_ID: NZ_CP025440_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025440_4

2866174-2866284

Orphan

Consensus_repeat	Method
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025440_4

>merge|NZ_CP025440|4|2866174-2866284|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAATGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAAAGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

>NZ_CP025440|4|3|2866174-2866284|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	TGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAA
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025440.1\|WP_003722061.1\|2863008_2863254_-\|YaaL-family-protein	unknown	unknown	gnl\|CDD\|378478
NZ_CP025440.1\|WP_009925039.1\|2869942_2870584_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_014601547.1\|2874980_2876720_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NZ_CP025440.1\|WP_003732087.1\|2871281_2872796_-\|gluconokinase	unknown	unknown	gnl\|CDD\|212659
NZ_CP025440.1\|WP_003725004.1\|2867409_2868774_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP025440.1\|WP_003722056.1\|2859110_2859707_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_CP025440.1\|WP_003722062.1\|2863268_2863865_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP025440.1\|WP_009930438.1\|2859710_2860085_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl\|CDD\|184702
NZ_CP025440.1\|WP_003727657.1\|2866868_2867051_-\|DUF3188-domain-containing-protein	unknown	unknown	gnl\|CDD\|371501
NZ_CP025440.1\|WP_009930437.1\|2858099_2859089_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NZ_CP025440.1\|WP_010990044.1\|2860190_2861042_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP025440.1\|WP_003722063.1\|2863973_2864291_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_CP025440.1\|WP_003722065.1\|2866386_2866851_-\|DUF3284-domain-containing-protein	unknown	unknown	gnl\|CDD\|378692
NZ_CP025440.1\|WP_003732088.1\|2872911_2873850_-\|GW-domain-containing-glycosaminoglycan-binding-protein	unknown	unknown	gnl\|CDD\|226309
NZ_CP025440.1\|WP_010990045.1\|2861160_2862000_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_CP025440.1\|WP_003722074.1\|2873892_2874840_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_CP025440.1\|WP_009931588.1\|2869215_2869371_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_003722067.1\|2867053_2867275_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025440.1\|WP_003732084.1\|2864320_2866060_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_CP025440.1\|WP_009931159.1\|2862120_2862963_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729

Protein	Function_ID	Function_description	E-value
NZ_CP025440.1\|WP_003722061.1\|2863008_2863254_-\|YaaL-family-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	2.68189e-15
NZ_CP025440.1\|WP_003725004.1\|2867409_2868774_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	3.47828e-162
NZ_CP025440.1\|WP_003722056.1\|2859110_2859707_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	3.29756e-82
NZ_CP025440.1\|WP_003722062.1\|2863268_2863865_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.77001e-132
NZ_CP025440.1\|WP_009930438.1\|2859710_2860085_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl\|CDD\|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	1.1917e-48
NZ_CP025440.1\|WP_003727657.1\|2866868_2867051_-\|DUF3188-domain-containing-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	1.21027e-11
NZ_CP025440.1\|WP_009930437.1\|2858099_2859089_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NZ_CP025440.1\|WP_010990044.1\|2860190_2861042_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	6.1079e-63
NZ_CP025440.1\|WP_003722063.1\|2863973_2864291_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	3.53269e-41
NZ_CP025440.1\|WP_003722065.1\|2866386_2866851_-\|DUF3284-domain-containing-protein	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	5.35099e-31
NZ_CP025440.1\|WP_003732088.1\|2872911_2873850_-\|GW-domain-containing-glycosaminoglycan-binding-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.04876e-98
NZ_CP025440.1\|WP_010990045.1\|2861160_2862000_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.49073e-86
NZ_CP025440.1\|WP_003722074.1\|2873892_2874840_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	1.13667e-05
NZ_CP025440.1\|WP_003732087.1\|2871281_2872796_-\|gluconokinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
NZ_CP025440.1\|WP_014601547.1\|2874980_2876720_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NZ_CP025440.1\|WP_003732084.1\|2864320_2866060_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP025440.1\|WP_009931159.1\|2862120_2862963_+\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	6.97706e-130

>NZ_CP025440.1|WP_003732084.1|2864320_2866060_-|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVEDALEITGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETMERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQSVAGGGNVPADAASGSDVSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASQDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDADAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
>NZ_CP025440.1|WP_003722063.1|2863973_2864291_-|YbaB/EbfC-family-nucleoid-associated-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEAQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNIPGM
>NZ_CP025440.1|WP_003722062.1|2863268_2863865_-|recombination-protein-RecR
MHYPEPITKLIDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSVICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKVTRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>NZ_CP025440.1|WP_003722061.1|2863008_2863254_-|YaaL-family-protein
MESRSNKFGRKKNKKIGKLHKSYDAYLMELIEVTQENWHKQKVLMRKSFEYDPNLEYEEKKAEARYFYLFKEARTRQLKNK
>NZ_CP025440.1|WP_009931159.1|2862120_2862963_+|aldo/keto-reductase
MTLSFSDTYRLNNGIEMPRHGFGVYKLTDEARMRTALETAVDVGYRLFDTASFYHNEKELGDFFASSGLKRDEFFVTTKMWNTEQGYDETLRAFEKSQKKLQLDQIDLYLVHWPKQDTFFDTWRAVEKLYDEGLVRAIGVSNFEAHHLDRLRTSANVLPVVDQLETHPHFPNHLLHRYLEELHIVHQAWSPLGRGGVLQEQILIDLAEKHGKSPAQIVLRWHLQNNISIIPKSETPSRIRENAAIYDFELSEADMRQVERLNTGERVSHAPDVMYVRSEI
>NZ_CP025440.1|WP_010990045.1|2861160_2862000_+|Cof-type-HAD-IIB-family-hydrolase
MTTQAIILDIDGTLLNDDKQISPETKKALITAQENGVKLILASGRPTTGMHVYAEQLEMEKHHGLLVSYNGAKVVDCATNEELFNQALTVEEGKAVLEHMKQFEVKVMIDKEDYMYTNDVYDCYVPYRGEEINIIQYESRGGNFKLCEKDDLAAFLDYRLSKILTAGDPAYMQKNYQAMMAPFKDTLNCVFTADFYFEFTAQGIDKAKALDTVLTPMGIHAENVIAFGDGHNDITMVEYAGTGIAMQNAVPELKAAASSVTLSNNEDGIAHVLNSLIPS
>NZ_CP025440.1|WP_010990044.1|2860190_2861042_+|MurR/RpiR-family-transcriptional-regulator
MNILIKIRELTNLTNSEKELANYILANPKKTLQFKPKELATAAFVSAATIYRLINKLGLNGIGELKIEIASSLRETSEEKDLNYDYPILESDTPYQIMTNLHQIYKGTIDETLNNADPEELVKIGEKLIQAKTIDVYAASANLFFAQNFKFQMQEIGVLVNVPEEDYIQSLSAANSDENHIAIVVSYGGRSRTLQRVVKILSENNVDIILITSMQDNPLVEFATHKIYMASAENHYNKVSSFSTRQSLLSIFDTLYSIYFNQNYEKNIQYKTTNYQKMNTELE
>NZ_CP025440.1|WP_009930438.1|2859710_2860085_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MAKPYGVVIISHSKDVAKGVHDIIKEIAPDVSITHAGGTEDGRIGTSFDAVNEAIENNEANKVYTFYDLGSAKMNIETVEEISEKEIILFNAPILEGAYATAAQVQMDEKPEVIAANLKTIEIK
>NZ_CP025440.1|WP_003722056.1|2859110_2859707_+|dihydroxyacetone-kinase-subunit-L
MTYDKDWALRWLNDFGERVQENKQLLSDLDQAIGDGDHGINMARGLGELKKAFTEKEPADLKDVFKTAGMTMVSKVGGASGPLYGTAFLNMSKAVDADTIDAVGLTKVIEAGLEGIEKRGKSHAGEKTMIDVWEPVVHALHQEDLTDDVVDAALQKTKDLKATKGRASYLGERSIGHLDPGAYSSALLFHAMLQTEVS
>NZ_CP025440.1|WP_009930437.1|2858099_2859089_+|dihydroxyacetone-kinase-subunit-DhaK
MKKILNGTDQVVEQMVEGLVKSHADVVHRVEGTRVIARNDKRPGKVGLVSGGGSGHEPAHAGYVGRGMLSAAVCGDVFTSPTPDQIYEGIKAADQGAGVLLIVKNYTGDVMNFEMAADLADADDIKVEQIVVDDDIAVEDSTFTTGRRGVAGTVLVHKIIGAAAEAGASLDELKALGEKVIASVKTLGVALSPCTVPEVGHPGFELGDDEIELGIGIHGEPGFTREKIMPSASLAKQLYERISNESKLLAGDKVVVLVNGMGATPLMEQYVFANDVHELLKNAGVQVEKTLVGDYMTSLEMAGLSLTILKLEDEKWVDMLKLPVDTIAW
>NZ_CP025440.1|WP_003722065.1|2866386_2866851_-|DUF3284-domain-containing-protein
MNVTQKLYISQKECFDTLVSSAIYDVKNATGKTLQVRKLEGYKYQRTMSNGALATTKIVKVQPNELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKALNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKQKQEKLAAKSEQ
>NZ_CP025440.1|WP_003727657.1|2866868_2867051_-|DUF3188-domain-containing-protein
MKIVNALFLISIGLIIIMFSPSYGKDGMASVPLLVTGLAVVLIGCVFIVLKIRKDKKEKN
>NZ_CP025440.1|WP_003722067.1|2867053_2867275_-|hypothetical-protein
MIILNCPMKRDYITELLETYDKDGVTFKKIDEKGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>NZ_CP025440.1|WP_003725004.1|2867409_2868774_-|PTS-sugar-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVEAMQPLIGINGYVYNGTLAIVSIIFAFSLGYNLSKAYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVATLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDSVPPAVSKAFAAIIPALVALYVVGIIDWAFFKITNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQEGAKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFLIAPMVMVTIAYFATTLGIVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>NZ_CP025440.1|WP_009931588.1|2869215_2869371_+|hypothetical-protein
MAVKRDMPEESKNSKVVKKEHFSIVFPDDIKEPATVEEKKKQDAEKKTDDN
>NZ_CP025440.1|WP_009925039.1|2869942_2870584_-|hypothetical-protein
MQQLKSKKKWLPALIVAVFVGIIVILAIMFGFFQRQEVFDKYEVAYEIDGKLYEVFPISATDIGVDKKSKDKNLYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDVYITNNESYATYDFFDKNGKKIYTYNPEETSNDDYIVRIKPTILQGYEKSDIGSYDDYLNITALFKDKLGMDVNVRIDEDKEMVIFSIK
>NZ_CP025440.1|WP_003732087.1|2871281_2872796_-|gluconokinase
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFDAVLTSIQAVMKNINTEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDFLPKVVPETYQLAGVKKEYAELMGIPENLPFIIGGSDGALANIGIQATGQNDVTITVGTSGAVRKLTDQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEAEISRRDFASFIAKIEEVPPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDAWCKLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFKQVTTQLMSSYSQLNSWQKKFDINS
>NZ_CP025440.1|WP_003732088.1|2872911_2873850_-|GW-domain-containing-glycosaminoglycan-binding-protein
MKKLLSGLIVVLMVSLLGHSFNAEAASYEKIIYDKAVNLKGVVNQSKRNDGINSKMYKTSSSVKYLGSAKKYDKKTLIITREGKTARAKWYYCKLGNTTIGWIDSRAFTNIGKPTIADAVPALWNSKKAIITTKPKSTTATTYFFQKNSAGNWYEVRHFTSHIGKWGFDPKFSEKSSGTPVGVYRTGIAFGQKGNPGTKLTFRAITNRSYWISNSNDKAYNTWQERNSSSSADEKMKIPQYKYGMEVKYNAKRVKGKGSAVFYHVDSPKYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFYGIN
>NZ_CP025440.1|WP_003722074.1|2873892_2874840_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKKFHGLILTALVTCLIIPFSLAASAETNENGNNSTPTEEKTTDTTENIITEEKTEPAEPTKDTTVTPPQKSKVQTTIDITDSQEVYSYEQNSKIDLKDFTATLTDYTDTKLTNYRLAANSKLSTAQTGIQEVTLLGDNEDGKTTAVKLNYLVKEKTAQLTITDMNFDLETKIFTGKTKPFASVYMSSPADENFGEGTTTADKDGYFYAEWATTPKQITAYAFDESGNYSEEVTYQVPAKKQNEAVVTAPDKVKKIETKNAVKSATTKPTDVTKVTKDDKTDLPSTGDKGTEWIFVVAGVIVILVAVLLLRKRKK
>NZ_CP025440.1|WP_014601547.1|2874980_2876720_-|thiol-reductant-ABC-exporter-subunit-CydC
MRKSSWIIPYIKENRGLFLLVIFLGTLTFASAGALMFTSGHLISKSSLMPESIMAVYISTVGVRAFGIMRSVSRYVERLSSHSLVLRILEKMRVRLYRLLEPQALLLKSRYKTGDILGLLAGDIEHLQNFYLTTMLPAIVSLVLYAGVVIALGAFSIPFAALFVLLIGLLVLVLPWVSLLYARGKNAYLKQGRNSLYQKFTDAVFGISDWKFSGREKTFISNYEKDEADMLRTENKQFHFVNWRDFFSQLVVGFMVIVMVYWSTAESRDGAFSGTLIAAFVLAIMALAEAFVPVSSAISDKSLYQDSLARLDKIEDPALPTFEEETKEIERINTENVVLKAENLTFAYNEKSPEILNGFDFTLQQGEKVAIIGRSGTGKSTFLKLVQGALLPTAGKVTMNDVEVEKLRPQIPELTSMLNQKAHLFSTTVLNNIRLGNQDASDEEVYEAAKKVQLHDFIMSMPDGYHTQMSEMGERFSGGERGRIALARILLQNTPIVILDEPTVGLDPITERDLLATIFETLADKSLIWVTHHLVGAEKMDRVLFLEEGKTLMEGPHAELMAEEPRYKRLYQLDRPIEL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP025440_3	3.3\|543282\|35\|NZ_CP025440\|PILER-CR,CRISPRCasFinder,CRT	543282-543316	35	MH341453	Listeria phage PSU-VKH-LP041, complete genome	10139-10173	1	0.971
NZ_CP025440_3	3.3\|543282\|35\|NZ_CP025440\|PILER-CR,CRISPRCasFinder,CRT	543282-543316	35	NC_009813	Listeria phage B054, complete genome	10139-10173	2	0.943

1. spacer 3.3|543282|35|NZ_CP025440|PILER-CR,CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 1, identity: 0.971

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacagcgatgggttacaa	Protospacer
*****************.*****************

2. spacer 3.3|543282|35|NZ_CP025440|PILER-CR,CRISPRCasFinder,CRT matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 2, identity: 0.943

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacggcgatgggttacaa	Protospacer
*****************.**.**************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

120653 : 127178

Listeria_phage(33.33%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721739.1\|120653_121106_-	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9
WP_003721740.1\|121111_121447_-	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003732219.1\|121663_122092_+	hypothetical protein	NA	NA	NA	NA
WP_003721742.1\|122103_122520_+	hypothetical protein	A8ASQ1	Listeria_phage	1.3e-20	39.3
WP_009930418.1\|122797_123187_+	DUF5072 domain-containing protein	NA	NA	NA	NA
WP_003721744.1\|123199_123712_+\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_003721745.1\|123759_124062_+	hypothetical protein	NA	NA	NA	NA
WP_009930419.1\|124103_124508_+	hypothetical protein	NA	NA	NA	NA
WP_010989347.1\|124494_126363_+	membrane protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_009911828.1\|126359_127178_+\|tail	phage tail family protein	A0A060AFE1	Staphylococcus_phage	7.2e-39	35.0

DBSCAN-SWA_2

1122845 : 1130268

Hokovirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721506.1\|1122845_1123229_+	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7
WP_010989659.1\|1123250_1124234_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	4.1e-12	34.6
WP_010989660.1\|1124248_1125262_+	glycosyltransferase	A0A1V0SAH6	Catovirus	7.9e-11	32.0
WP_003721509.1\|1125470_1126961_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
WP_009931487.1\|1126972_1127797_+	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	7.4e-68	52.6
WP_009931485.1\|1127809_1128118_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_009931483.1\|1128178_1128583_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_010989661.1\|1128711_1130268_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.3e-17	28.1

DBSCAN-SWA_3

1244317 : 1324837

Listeria_phage(79.66%)

terminase,protease,capsid,tail,holin,portal,integrase,tRNA

attL 1244201:1244217|attR 1287135:1287151

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1244201:1244217	attL	NA	NA	NA	NA
WP_039153598.1\|1244317_1245472_-\|integrase	site-specific integrase	A8ATC7	Listeria_phage	3.4e-204	92.4
WP_039153595.1\|1245606_1246041_-	hypothetical protein	Q8W5Y2	Listeria_phage	6.5e-55	81.2
WP_039153592.1\|1246056_1246626_-	DUF4352 domain-containing protein	R4IBV3	Listeria_phage	9.8e-11	92.3
WP_039153589.1\|1246676_1247129_-	ImmA/IrrE family metallo-endopeptidase	R4IBK9	Listeria_phage	1.1e-78	90.7
WP_039153587.1\|1247145_1247469_-	helix-turn-helix transcriptional regulator	A0A059T6G1	Listeria_phage	4.7e-34	69.2
WP_003730994.1\|1248098_1248302_-	hypothetical protein	NA	NA	NA	NA
WP_003730995.1\|1248368_1248560_+	helix-turn-helix transcriptional regulator	A0A059T5F8	Listeria_phage	5.4e-22	87.1
WP_003730996.1\|1248581_1248824_+	hypothetical protein	A8ATD2	Listeria_phage	3.9e-41	93.8
WP_003730997.1\|1248826_1249012_+	hypothetical protein	A8ATD3	Listeria_phage	3.7e-28	98.4
WP_009931094.1\|1249535_1249826_+	hypothetical protein	A0A059T7V3	Listeria_phage	1.8e-40	89.4
WP_031659545.1\|1249843_1250026_+	hypothetical protein	NA	NA	NA	NA
WP_014930119.1\|1250219_1250495_+	hypothetical protein	R4ICD2	Listeria_phage	3.4e-41	94.3
WP_009931089.1\|1250491_1250935_+	hypothetical protein	NA	NA	NA	NA
WP_014930120.1\|1250951_1251260_+	hypothetical protein	NA	NA	NA	NA
WP_157824771.1\|1251995_1252169_+	hypothetical protein	NA	NA	NA	NA
WP_009932944.1\|1252395_1253025_+	hypothetical protein	A0A191KBJ8	Streptococcus_virus	2.4e-66	57.9
WP_003722554.1\|1253043_1253211_+	hypothetical protein	NA	NA	NA	NA
WP_045131531.1\|1253314_1253491_+	hypothetical protein	A0A076G7F4	Listeria_phage	5.5e-21	86.2
WP_014930124.1\|1253487_1253889_+	hypothetical protein	A8ATD9	Listeria_phage	7.8e-71	95.5
WP_025283119.1\|1253885_1254092_+	hypothetical protein	A0A059T6C7	Listeria_phage	1.7e-29	92.6
WP_154079741.1\|1254118_1254289_+	hypothetical protein	A0A059T654	Listeria_phage	2.4e-21	92.3
WP_023548953.1\|1254285_1254720_+	hypothetical protein	A8ATS7	Listeria_phage	2.5e-38	52.8
WP_015987318.1\|1254922_1255306_+	hypothetical protein	A8ATE8	Listeria_phage	2.5e-66	100.0
WP_039153573.1\|1255307_1255787_+	siphovirus Gp157 family protein	R4IBM0	Listeria_phage	1.9e-76	97.5
WP_039153570.1\|1255799_1256489_+	AAA family ATPase	R4IDY8	Listeria_phage	6.8e-123	91.7
WP_072215795.1\|1256567_1257809_+	DEAD/DEAH box helicase	A8ATF1	Listeria_phage	1.5e-213	95.8
WP_039153564.1\|1257831_1258314_+	DUF669 domain-containing protein	A8ATF2	Listeria_phage	9.3e-87	98.8
WP_039153561.1\|1258336_1260625_+	DNA primase	A8ATF3	Listeria_phage	0.0e+00	93.9
WP_014601407.1\|1260958_1261276_+	VRR-NUC domain-containing protein	A8ATF4	Listeria_phage	9.2e-51	95.1
WP_003731659.1\|1261277_1261490_+	hypothetical protein	NA	NA	NA	NA
WP_046422201.1\|1262079_1262619_+	DUF3310 domain-containing protein	A8ATF5	Listeria_phage	1.2e-71	74.9
WP_045131521.1\|1262615_1262894_+	hypothetical protein	NA	NA	NA	NA
WP_003731655.1\|1263129_1263357_+	hypothetical protein	NA	NA	NA	NA
WP_009917712.1\|1263369_1263795_+	DUF722 domain-containing protein	A0A059T6H4	Listeria_phage	8.0e-74	100.0
WP_045131520.1\|1263892_1264636_+	DUF559 domain-containing protein	NA	NA	NA	NA
WP_003731652.1\|1264876_1265191_+	HNH endonuclease	A8ATF8	Listeria_phage	3.2e-56	98.1
WP_031646261.1\|1265239_1265596_+	hypothetical protein	A8AT94	Listeria_phage	2.6e-46	98.0
WP_023552366.1\|1265592_1267236_+\|terminase	terminase large subunit	A8AT95	Listeria_phage	0.0e+00	98.7
WP_023548926.1\|1267247_1268378_+\|portal	phage portal protein	A8AT96	Listeria_phage	1.7e-203	93.1
WP_031669132.1\|1268374_1269181_+\|protease	Clp protease ClpP	A0A059T5F2	Listeria_phage	3.8e-133	93.3
WP_003731647.1\|1269207_1270359_+\|capsid	phage major capsid protein	A8AT98	Listeria_phage	2.7e-201	93.2
WP_003731645.1\|1270545_1270845_+	hypothetical protein	A8ATA0	Listeria_phage	5.3e-48	100.0
WP_003731644.1\|1270828_1271194_+	hypothetical protein	A8ATA1	Listeria_phage	1.3e-64	100.0
WP_003731643.1\|1271190_1271592_+	hypothetical protein	A8ATA2	Listeria_phage	2.1e-68	100.0
WP_012581456.1\|1271588_1271972_+	hypothetical protein	A8ATA3	Listeria_phage	3.8e-67	100.0
WP_031672556.1\|1271993_1272581_+\|tail	phage tail protein	A8ATA4	Listeria_phage	5.8e-107	99.5
WP_009917698.1\|1272651_1272984_+	hypothetical protein	A8ATA5	Listeria_phage	1.8e-52	99.1
WP_014589052.1\|1273001_1273184_+	hypothetical protein	A8ATA6	Listeria_phage	2.8e-20	100.0
WP_039153543.1\|1273199_1278011_+\|tail	phage tail tape measure protein	A0A059T5F4	Listeria_phage	0.0e+00	70.3
WP_031644613.1\|1277998_1279648_+\|tail	phage tail protein	A0A059T682	Listeria_phage	0.0e+00	99.5
WP_012951555.1\|1279660_1281955_+	hypothetical protein	A0A059T7Y6	Listeria_phage	0.0e+00	94.0
WP_031644619.1\|1281944_1283039_+	hypothetical protein	A0A059T7R4	Listeria_phage	2.2e-184	87.9
WP_012951557.1\|1283086_1283389_+	hypothetical protein	A0A059T5E6	Listeria_phage	1.7e-38	93.0
WP_012951558.1\|1283388_1283646_+\|holin	phage holin	A8ATB7	Listeria_phage	3.2e-25	69.0
WP_014930134.1\|1283645_1284488_+	peptidase M15	A0A059T7Y8	Listeria_phage	9.5e-127	81.6
WP_039153008.1\|1284591_1285590_+	DUF3644 domain-containing protein	A0A0N9RUA4	Staphylococcus_phage	2.3e-71	44.8
WP_003769913.1\|1285804_1286011_-	hypothetical protein	A0A059T7Z0	Listeria_phage	1.3e-16	82.8
WP_009933529.1\|1286601_1286835_+	hypothetical protein	R4IDW6	Listeria_phage	2.8e-28	78.9
WP_009933528.1\|1286831_1287023_+	hypothetical protein	R4IBI5	Listeria_phage	8.9e-25	88.9
WP_010989715.1\|1287516_1288875_+	DUF1254 domain-containing protein	NA	NA	NA	NA
1287135:1287151	attR	NA	NA	NA	NA
WP_010989716.1\|1288916_1289510_-	hypothetical protein	NA	NA	NA	NA
WP_009914084.1\|1289663_1290071_-	glyoxalase/bleomycin resistance/extradiol dioxygenase family protein	NA	NA	NA	NA
WP_009924169.1\|1290235_1290835_+	histidine phosphatase family protein	A0A1X9IGJ2	Lactococcus_phage	5.8e-30	41.0
WP_003723543.1\|1290866_1291127_-	hypothetical protein	NA	NA	NA	NA
WP_101336014.1\|1291250_1292663_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.7e-56	33.7
WP_003723545.1\|1292687_1292951_+	DUF3116 family protein	NA	NA	NA	NA
WP_003723546.1\|1293117_1293594_+	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_003723547.1\|1293631_1293877_-	hypothetical protein	NA	NA	NA	NA
WP_003723548.1\|1293873_1295079_-	MFS transporter	NA	NA	NA	NA
WP_003723549.1\|1295283_1295943_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_003723550.1\|1295984_1296179_-	hypothetical protein	NA	NA	NA	NA
WP_003723551.1\|1296245_1297094_-	YitT family protein	NA	NA	NA	NA
WP_009931701.1\|1297712_1298426_+	trehalose operon repressor	NA	NA	NA	NA
WP_010989718.1\|1298456_1300103_-	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_003723556.1\|1300121_1301606_-	PTS system trehalose-specific EIIBC component	NA	NA	NA	NA
WP_003723557.1\|1301721_1302174_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_003723558.1\|1302220_1302685_-	hypothetical protein	NA	NA	NA	NA
WP_003723559.1\|1302873_1303794_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_009932313.1\|1303813_1305061_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.2e-106	51.8
WP_003723561.1\|1305044_1305875_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	4.3e-47	42.4
WP_003723562.1\|1306010_1307150_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_003723563.1\|1307230_1307626_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|1307776_1307992_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_010989719.1\|1308110_1308644_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003732795.1\|1308661_1309327_+	hypothetical protein	NA	NA	NA	NA
WP_003732796.1\|1309588_1310527_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|1310641_1311925_+	trigger factor	NA	NA	NA	NA
WP_003723886.1\|1312110_1313370_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.4e-145	63.2
WP_003723887.1\|1313488_1314055_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_003723888.1\|1314089_1314659_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003723889.1\|1314760_1315303_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003723890.1\|1315312_1316176_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_003723891.1\|1316172_1316958_+	ribonuclease HII	G4YAY0	Emiliania_huxleyi_virus	3.0e-26	39.2
WP_010989720.1\|1317091_1317952_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_009924617.1\|1318223_1320302_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	1.4e-107	37.7
WP_010989721.1\|1320364_1321669_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_009911635.1\|1321951_1322854_+	tyrosine recombinase XerC	A0A097EYL9	Mycobacterium_phage	1.2e-13	28.6
WP_014601431.1\|1322874_1323414_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_010989722.1\|1323427_1324837_+\|protease	ATP-dependent protease ATPase subunit HslU	W6AS21	Erwinia_phage	4.9e-43	27.7

DBSCAN-SWA_4

1796298 : 1829164

Erysipelothrix_phage(67.74%)

terminase,protease,capsid,holin,head,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014929970.1\|1796298_1797213_-	N-acetylmuramoyl-L-alanine amidase	A0A1D8ETE4	Propionibacterium_phage	3.9e-33	44.0
WP_025186379.1\|1797202_1797616_-\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	1.5e-37	57.0
WP_003731143.1\|1797664_1798084_-	DUF1617 family protein	A0A1S5RCP5	Lactobacillus_phage	2.4e-06	26.5
WP_003731141.1\|1798244_1802309_-	hypothetical protein	A0A1B1P770	Bacillus_phage	8.7e-85	41.8
WP_003731140.1\|1802293_1802986_-	hypothetical protein	A0A1L2BYA2	Clostridium_phage	1.7e-20	29.0
WP_003731139.1\|1803001_1805563_-	hypothetical protein	A0A2K5B297	Erysipelothrix_phage	3.9e-83	74.1
WP_003731138.1\|1805630_1806275_-	DUF1643 domain-containing protein	NA	NA	NA	NA
WP_003731137.1\|1806526_1806910_-	hypothetical protein	A0A2K5B295	Erysipelothrix_phage	5.4e-37	64.2
WP_003731136.1\|1806919_1807510_-\|tail	phage tail protein	A0A2K5B294	Erysipelothrix_phage	4.1e-76	72.2
WP_029645088.1\|1807511_1807820_-	hypothetical protein	NA	NA	NA	NA
WP_003731135.1\|1807846_1808278_-	HK97 gp10 family phage protein	A0A2K5B292	Erysipelothrix_phage	7.6e-40	59.4
WP_003731134.1\|1808270_1808609_-\|head,tail	head-tail adaptor protein	A0A2K5B291	Erysipelothrix_phage	1.7e-23	54.7
WP_003731133.1\|1808605_1808917_-\|head,tail	phage gp6-like head-tail connector protein	A0A2K5B290	Erysipelothrix_phage	2.2e-36	74.0
WP_003731132.1\|1808927_1810145_-\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	1.1e-102	48.0
WP_095591263.1\|1810148_1810901_-\|protease	Clp protease ClpP	M1PLE5	Streptococcus_phage	1.9e-62	55.7
WP_014929974.1\|1810797_1812159_-\|portal	phage portal protein	A0A2K5B287	Erysipelothrix_phage	2.7e-179	74.0
WP_100066221.1\|1812226_1812487_-	hypothetical protein	NA	NA	NA	NA
WP_088518322.1\|1812618_1814211_-\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	7.2e-269	84.8
WP_003731127.1\|1814271_1814496_-	hypothetical protein	A0A2K5B284	Erysipelothrix_phage	2.0e-15	48.6
WP_003731126.1\|1814485_1814683_-	DUF5049 domain-containing protein	NA	NA	NA	NA
WP_003731125.1\|1814657_1814852_-	hypothetical protein	NA	NA	NA	NA
WP_003731124.1\|1814854_1815244_-	DUF4314 domain-containing protein	E4ZFL7	Streptococcus_phage	3.1e-16	71.0
WP_003731123.1\|1815332_1816583_-	site-specific DNA-methyltransferase	A0A2I4R670	Erysipelothrix_phage	7.4e-144	62.0
WP_003731122.1\|1816572_1817175_-	HNH endonuclease	A0A0B5HE03	Vibrio_phage	1.1e-12	37.6
WP_014929977.1\|1817174_1817957_-	S-adenosylmethionine synthetase	NA	NA	NA	NA
WP_031641527.1\|1817961_1818540_-\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	1.2e-53	52.8
WP_031641526.1\|1818672_1819038_-	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	1.4e-31	56.9
WP_003731117.1\|1819205_1819634_-	DUF1492 domain-containing protein	A0A2K5B275	Erysipelothrix_phage	1.5e-27	45.8
WP_014929979.1\|1819630_1820983_-	DEAD/DEAH box helicase	A0A2K5B273	Erysipelothrix_phage	6.8e-159	69.0
WP_003731115.1\|1820982_1821267_-	VRR-NUC domain-containing protein	A0A2K5B272	Erysipelothrix_phage	3.5e-25	60.2
WP_003731114.1\|1821263_1821473_-	hypothetical protein	NA	NA	NA	NA
WP_003731113.1\|1821610_1823854_-	hypothetical protein	A0A1B0RXC5	Streptococcus_phage	4.8e-210	49.7
WP_014929980.1\|1823846_1824191_-	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	4.1e-28	51.4
WP_014929981.1\|1824183_1824954_-	phage antirepressor KilAC domain-containing protein	A0A1Q1PVU2	Staphylococcus_phage	2.7e-64	50.8
WP_003731110.1\|1825164_1827102_-	DNA polymerase	A0A2K5B2B0	Erysipelothrix_phage	7.7e-265	68.6
WP_003731109.1\|1827162_1827705_-	DUF2815 family protein	A0A2K5B2A9	Erysipelothrix_phage	8.9e-78	77.2
WP_003731108.1\|1827706_1828849_-	DUF2800 domain-containing protein	M1Q218	Streptococcus_phage	1.5e-122	57.8
WP_010821424.1\|1828849_1829164_-	hypothetical protein	A0A2K5B2A7	Erysipelothrix_phage	6.6e-09	41.5

DBSCAN-SWA_5

1913347 : 1921633

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722243.1\|1913347_1913914_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9
WP_009933235.1\|1913910_1914960_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.0e-61	43.2
WP_010989807.1\|1914978_1916406_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	8.1e-54	31.9
WP_010989808.1\|1916390_1918610_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.0e-160	41.2
WP_003733240.1\|1918602_1919286_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003722248.1\|1919289_1919535_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_010989809.1\|1919546_1920260_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.3e-41	38.3
WP_003733238.1\|1920340_1921633_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	7.2e-17	32.6

DBSCAN-SWA_6

2436414 : 2474913

Listeria_phage(96.08%)

plate,terminase,holin,capsid,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003769913.1\|2436414_2436621_+	hypothetical protein	A0A059T7Z0	Listeria_phage	1.3e-16	82.8
WP_039153008.1\|2436835_2437834_-	DUF3644 domain-containing protein	A0A0N9RUA4	Staphylococcus_phage	2.3e-71	44.8
WP_014601492.1\|2437936_2438782_-	peptidase M15	A0A059T7Y8	Listeria_phage	1.8e-133	90.8
WP_003733521.1\|2438781_2439048_-\|holin	phage holin	A0A059T684	Listeria_phage	9.8e-38	93.1
WP_039177480.1\|2439047_2439350_-	hypothetical protein	A0A059T5E6	Listeria_phage	2.7e-39	94.1
WP_003722524.1\|2439390_2439549_-	hypothetical protein	Q9T1A1	Listeria_phage	6.0e-19	100.0
WP_003722525.1\|2439553_2439871_-	hypothetical protein	Q9T1A2	Listeria_phage	6.2e-55	100.0
WP_039120293.1\|2439882_2440956_-\|plate	phage baseplate upper protein	Q9T1A3	Listeria_phage	7.2e-196	98.9
WP_097592621.1\|2440955_2441984_-	hypothetical protein	Q9T1A4	Listeria_phage	2.8e-189	98.2
WP_077310942.1\|2441984_2443010_-	hypothetical protein	Q9T1A5	Listeria_phage	6.2e-181	88.3
WP_077310940.1\|2443018_2443837_-\|tail	phage tail family protein	Q9T1A6	Listeria_phage	8.8e-146	91.2
WP_101924631.1\|2443838_2449223_-	tape measure protein	Q9T1A7	Listeria_phage	0.0e+00	94.3
WP_003735024.1\|2449233_2449833_-	hypothetical protein	A0A0B5CTW0	Listeria_phage	1.9e-76	72.0
WP_039177488.1\|2449838_2450261_-\|tail	phage tail assembly chaperone	Q9T1A9	Listeria_phage	1.6e-66	93.6
WP_045552940.1\|2450313_2450646_-	Ig-like virion protein	Q9T1B0	Listeria_phage	1.5e-30	70.9
WP_003769949.1\|2450575_2451010_-\|tail	tail protein	Q9T1B1	Listeria_phage	6.0e-77	98.6
WP_003727788.1\|2451012_2451420_-	hypothetical protein	Q9T1B2	Listeria_phage	9.0e-67	98.5
WP_061106990.1\|2451419_2451758_-\|capsid	minor capsid protein	A0A059T7W4	Listeria_phage	2.3e-55	92.9
WP_061112566.1\|2451757_2452120_-\|capsid	minor capsid protein	A0A0B5D151	Listeria_phage	2.0e-62	97.5
WP_061112567.1\|2452119_2452515_-	hypothetical protein	A0A059T5E3	Listeria_phage	3.8e-62	93.1
WP_003769954.1\|2452532_2453534_-	hypothetical protein	A0A059T6D4	Listeria_phage	1.1e-182	97.6
WP_003727783.1\|2453533_2454124_-	scaffold protein	Q9T1B8	Listeria_phage	2.6e-75	89.8
WP_101903826.1\|2454202_2455342_-\|capsid	minor capsid protein	Q9T1B9	Listeria_phage	8.1e-198	93.1
WP_100944779.1\|2455342_2457103_-\|portal	phage portal protein	A0A0B5D0F2	Listeria_phage	8.5e-271	94.8
WP_039177588.1\|2457115_2458447_-\|terminase	PBSX family phage terminase large subunit	A0A059T5E2	Listeria_phage	4.5e-256	96.2
WP_039120307.1\|2458415_2458958_-\|terminase	terminase small subunit	A0A0B5CU16	Listeria_phage	4.9e-84	95.5
WP_140442387.1\|2459004_2459190_-	hypothetical protein	NA	NA	NA	NA
WP_025370640.1\|2459447_2459882_-	hypothetical protein	A8ASQ1	Listeria_phage	3.1e-57	76.4
WP_003733720.1\|2459946_2460444_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	1.8e-32	49.3
WP_003733721.1\|2460433_2460616_-	hypothetical protein	A8ASP6	Listeria_phage	1.1e-16	79.4
WP_014601507.1\|2460634_2461117_-	single-stranded DNA-binding protein	A0A059T5E0	Listeria_phage	1.1e-52	66.9
WP_014601509.1\|2461344_2461554_-	hypothetical protein	A8ATE0	Listeria_phage	1.7e-32	100.0
WP_014601510.1\|2461550_2461952_-	hypothetical protein	A8ATD9	Listeria_phage	2.6e-74	100.0
WP_100944780.1\|2462010_2462571_-	DUF1642 domain-containing protein	A8ATY9	Listeria_phage	8.0e-106	98.9
WP_003731837.1\|2462582_2463191_-	hypothetical protein	A8ATU1	Listeria_phage	1.4e-55	49.5
WP_003731843.1\|2463990_2464206_-	hypothetical protein	NA	NA	NA	NA
WP_014601515.1\|2464389_2464845_-	class I SAM-dependent methyltransferase	A0A059T693	Listeria_phage	4.2e-81	90.7
WP_060571423.1\|2464841_2465816_-	DnaD domain protein	A8ASN4	Listeria_phage	4.9e-151	85.2
WP_060571424.1\|2465832_2466471_-	ERF family protein	A8ASN3	Listeria_phage	2.9e-80	76.3
WP_097592577.1\|2466475_2466952_-	siphovirus Gp157 family protein	A8ASN2	Listeria_phage	1.7e-56	94.3
WP_009930470.1\|2466948_2467143_-	hypothetical protein	A0A059T6E8	Listeria_phage	1.8e-28	95.3
WP_003769989.1\|2467444_2467633_-	hypothetical protein	A8ATY3	Listeria_phage	2.5e-27	95.2
WP_003769990.1\|2467740_2467956_-	hypothetical protein	Q9T176	Listeria_phage	6.1e-22	73.2
WP_009930464.1\|2467952_2468486_-	hypothetical protein	A0A059T5F0	Listeria_phage	1.1e-75	84.4
WP_003769993.1\|2468610_2469390_-	phage antirepressor Ant	A0A059T6E7	Listeria_phage	2.0e-139	96.9
WP_025370647.1\|2469453_2469696_+	hypothetical protein	A0A059T7Q3	Listeria_phage	1.5e-37	98.8
WP_003769995.1\|2469881_2470163_-	hypothetical protein	Q9T180	Listeria_phage	1.4e-39	96.8
WP_003733634.1\|2470159_2470396_-	hypothetical protein	A0A059T5E9	Listeria_phage	3.3e-37	100.0
WP_003727745.1\|2470407_2470602_-	hypothetical protein	A0A059T6E5	Listeria_phage	6.3e-26	96.9
WP_015967158.1\|2470668_2470836_+	hypothetical protein	Q9T182	Listeria_phage	5.6e-23	100.0
WP_046155079.1\|2471202_2471514_+	hypothetical protein	NA	NA	NA	NA
WP_003770002.1\|2471473_2471659_-	hypothetical protein	NA	NA	NA	NA
WP_003727743.1\|2471882_2472149_-	hypothetical protein	A0A059T7Q1	Listeria_phage	2.5e-41	100.0
WP_009930459.1\|2472181_2472385_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_060571428.1\|2472553_2473030_+	helix-turn-helix transcriptional regulator	A8ASM2	Listeria_phage	1.1e-36	56.3
WP_012582373.1\|2473185_2473353_+	hypothetical protein	NA	NA	NA	NA
WP_060571433.1\|2473409_2474060_+	hypothetical protein	NA	NA	NA	NA
WP_061112578.1\|2474385_2474913_+	hypothetical protein	A0A0B5D0D1	Listeria_phage	1.6e-07	34.4

DBSCAN-SWA_7

2622250 : 2630094

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722604.1\|2622250_2623222_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
WP_003722605.1\|2623229_2624198_-	YvcK family protein	A1IMD5	Streptococcus_phage	6.7e-68	43.3
WP_010990001.1\|2624199_2625075_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.2e-08	29.7
WP_010990002.1\|2625182_2626913_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.3e-175	54.0
WP_009930954.1\|2626954_2628016_-	galactose mutarotase	NA	NA	NA	NA
WP_009924988.1\|2628032_2629016_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	2.6e-51	37.2
WP_003722610.1\|2629134_2630094_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP025441

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP025440

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection