CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP025931	Porphyromonas gingivalis strain TDC 60 chromosome, complete genome	8 crisprs	Csx28,PD-DExK,DEDDh,cas3,cas2,cas1,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,cas4,cas7b,cas8b4,cas5,cas6	7	5	1	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP025931_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_1

6623-6770

Orphan

Consensus_repeat	Method
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCAACTGAGCTAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025931_1

>merge|NZ_CP025931|1|6623-6770|CRISPRCasFinder
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCAACTGAGCTAAGGAAGAATAGAAAAACGGCTTATGAGAGCGCTTTCTCTTGGGCTCGAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCGACTGAGCTAAG

>NZ_CP025931|1|1|6623-6770|CRISPRCasFinder
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCAACTGAGCTAAG	GAAGAATAGAAAAACGGCTTATGAGAGCGCTTTCTCTTGGGCTC
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCGACTGAGCTAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_013815109.1\|10120_13132_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224389
NZ_CP025931.1\|WP_013815102.1\|0_1422_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NZ_CP025931.1\|WP_013815111.1\|15532_16882_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP025931.1\|WP_004583405.1\|1434_2007_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|100048
NZ_CP025931.1\|WP_013815108.1\|7401_9981_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_CP025931.1\|WP_043889966.1\|18233_20480_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815104.1\|3107_3815_+\|NAD-dependent-deacylase	unknown	unknown	gnl\|CDD\|234777
NZ_CP025931.1\|WP_013815114.1\|20564_21260_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP025931.1\|WP_013815105.1\|5095_6475_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240548
NZ_CP025931.1\|WP_043889965.1\|2008_3028_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|225813
NZ_CP025931.1\|WP_013815110.1\|14217_14988_+\|2-phosphosulfolactate-phosphatase	unknown	unknown	gnl\|CDD\|377205
NZ_CP025931.1\|WP_013815115.1\|21254_22256_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|239200
NZ_CP025931.1\|WP_148271453.1\|6959_7262_+\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_004583413.1\|13179_14208_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|273466
NZ_CP025931.1\|WP_005874752.1\|3888_5043_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP025931.1\|WP_013815112.1\|16892_18230_+\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|227333

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_013815109.1\|10120_13132_+\|serine-hydrolase	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	5.14836e-77
NZ_CP025931.1\|WP_013815102.1\|0_1422_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP025931.1\|WP_013815111.1\|15532_16882_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.78173e-166
NZ_CP025931.1\|WP_004583405.1\|1434_2007_+\|N-acetyltransferase	gnl\|CDD\|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	2.87631e-63
NZ_CP025931.1\|WP_013815108.1\|7401_9981_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP025931.1\|WP_013815104.1\|3107_3815_+\|NAD-dependent-deacylase	gnl\|CDD\|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	6.40551e-107
NZ_CP025931.1\|WP_013815114.1\|20564_21260_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.09974e-11
NZ_CP025931.1\|WP_013815105.1\|5095_6475_-\|MATE-family-efflux-transporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	2.49528e-131
NZ_CP025931.1\|WP_043889965.1\|2008_3028_-\|acyltransferase-family-protein	gnl\|CDD\|225813	COG3274, COG3274, Predicted O-acyltransferase [General function prediction only].	1.91054e-19
NZ_CP025931.1\|WP_013815110.1\|14217_14988_+\|2-phosphosulfolactate-phosphatase	gnl\|CDD\|377205	pfam04029, 2-ph_phosp, 2-phosphosulpholactate phosphatase. Thought to catalyze 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor. Involved in the second step of coenzyme M biosynthesis. Inhibited by vanadate in Methanococcus jannaschii. Also known as the ComB family.	6.72157e-81
NZ_CP025931.1\|WP_013815115.1\|21254_22256_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|239200	cd02801, DUS_like_FMN, Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present.	1.24319e-109
NZ_CP025931.1\|WP_148271453.1\|6959_7262_+\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	1.26604e-05
NZ_CP025931.1\|WP_004583413.1\|13179_14208_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|273466	TIGR01140, L_thr_O3P_dcar, L-threonine-O-3-phosphate decarboxylase. This family contains pyridoxal phosphate-binding class II aminotransferases (see pfamAM:pfam00222) closely related to, yet distinct from, histidinol-phosphate aminotransferase (HisC). It is found in cobalamin biosynthesis operons in Salmonella typhimurium and Bacillus halodurans (each of which also has HisC) and has been shown to have L-threonine-O-3-phosphate decarboxylase activity in Salmonella. Although the gene symbol cobD was assigned in Salmonella, cobD in other contexts refers to a different cobalamin biosynthesis enzyme, modeled by pfam03186 and called cbiB in Salmonella. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	2.20574e-68
NZ_CP025931.1\|WP_005874752.1\|3888_5043_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.48097e-50
NZ_CP025931.1\|WP_013815112.1\|16892_18230_+\|GHKL-domain-containing-protein	gnl\|CDD\|227333	COG5000, NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms].	3.06869e-32

>NZ_CP025931.1|WP_013815105.1|5095_6475_-|MATE-family-efflux-transporter
MSSQQIQALESEKIPKLLFHYALPAVVGTAVNSLYNIVDRIFIGNGVSEYALSGLAITFPILIFLMAFGMLVGAGASVRVSILLGRKDIKEAEHTLANAIFLTFFTQALTIIPCYIFMEPLLRLFGASERTLPYAMEYLQYVVPANIFSALSFGFNAIMRASGYPRKAMITMIIGAMTNVVLDYIFIYPLGMGISGAAIATVISMIVCSVYVLSHFFRKDSIVRFHRSAFRLSLPVISGITAIGVAPFAMHLTGSLVNIIMNRSFVSYGETADATDLAIGAFGIINGYAMLFFMIIIGVAQGMQPIVGFNYGAKNPGRVKSAYRYSCGVNLLVSFLGFALAMLMPRTIVSLFTNSEQMIELSASALRTALIGLSLVGFQVTTTQFFQSIGFSHKAIFLSLTRQIIFLIPCLLIIPRFMGLDGVWWSLPISDLASVVLSFVLITIQMKHFNQSKKTTFAE
>NZ_CP025931.1|WP_005874752.1|3888_5043_-|metallophosphoesterase
MKVFLEAFLLQYLLTLYIAYRGGQALPQKSLWRKGFHLLMGVVFTLYLIGFAGNRVLPDAVMSCIMSVTGFWFVMSIYAMFAMVIVEIARVVDKRFLHRFDRLSERVQARIRLGLFVLIGLSSALLVIHGLNIVRYPVVKHMDIRLDRPAIDGRQSMKVALLTDIHISETVTAGHIREMVERTLAERPDIVLIGGDMIDYHGRYARRDSITEYMRRLQDETPMGAYYVLGNHEYRADEVEKREWFRSIGHLVIDQVVTPGNAFYLIGRDDSTNVFRAPLHKLMPHVDTTKASILLDHQPHKLDSVAMTGVDLALYGHTHNGQIWPFTILTQLAFEKSWGYLRKGHTQFYVSSGVGAAGPAIRVFTESEIVILNVRFASENKPVH
>NZ_CP025931.1|WP_013815104.1|3107_3815_+|NAD-dependent-deacylase
MNKKRLVVLSGAGMSAESGISTFRDANGLWENYPVEDVASIDGFRRNPALVLKFYNARRRDYAGCKPNAGHIGLAEMEKEYDVRIITQNVDDLHERAGSTRVIHLHGELMKNRSVATDSVLYPVDPTNPDLHVGDLAPDGCQLRPFIVWFGEAVPMIEPAIEEVTQADILVVIGTSLNVYPAAGLLNYAPRNCPIYLIDPKPVRSTSRQDIRYIHAPATEGVRMLRQELRDIIDC
>NZ_CP025931.1|WP_043889965.1|2008_3028_-|acyltransferase-family-protein
MTTKGRNTTVDVLRVLAGLMVIGIHTSGEYVLEGVAEGANFIAGLCWETVVQPAVPIFVIISGAFVLGRNETWGDFYRKRIPRLLVLLAFWLPFYWLWLWLKGDDIGSYLAGFWQGRSFVHLWYVVMLLGLYAVVPLLNEIIRRCEADGEKAARKRLWTLSTILLLLGILSNTYDYILGYNRFFPFLWPDYLGYFLVGYTLKCHAPQRSLPALSLYGLSTISLFFASRYAFEHGEGLYFYRNLSPLIVLSAISLFALFVSWGGCGGKLARIGKMQGDILGIYLVHIAVLNVVTKILVLTTPSLMQCAWLNIPIRVGLVFFVSWGVVRLMKRLPICRYLV
>NZ_CP025931.1|WP_004583405.1|1434_2007_+|N-acetyltransferase
MIHPTAIVEDGCVLGQGTRVWHFSHLMCGAEVGENCNIGQNVVIMPEVRLGRGCKVQNNVSLYSGVVCEDYVFLGPSCVFTNVINPRAFIERKSEYRPTHLHEGVSIGANATILCGITIGAYAMVGAGTVVIRDVPPYALVVGNPARRIGWVSRAGHRLSFDDKGMAVCPETGERYREVEETGTIEPVSD
>NZ_CP025931.1|WP_013815102.1|0_1422_+|chromosomal-replication-initiator-protein-DnaA
MNYHSTNVNEIWDACLRILQDIVDERAYRTWFLPIIPVSIEGDTLTLQVPSQFFCEFLEGNFVEQLRTVLGRVIGPNASLQYNALVDNSSPKYPGTVTLAGCADGGQAAEQFDVNLLHRHMLNAATHSEAQDFDTQLNSRLNFRNFYQSECNYVARSVAEAIAASPGNTPMNPFFIYGASGVGKTHLCHALGLRVREMHPRLKVLYVSSHLFEMQFTTAARMGTINDFIVFYQQVDVLIIDDIQWLIGKKKTQLAFFQVFNHLYMLGKQIVLTSDKPPVDLNGMEERLVTRMAGATCVKIERPDLKLRREILQQRTLQSGVRLDESVLNFIAENVCDNVRELEGTLVSLITNSVVVGKEIDLTFAKRIVRQAVRLEKKEVTIECIQQAVSRVFQVQIEQMKSKSRKQDIVQARQVVMFLSKKHTAQSLSAIGELMGGRNHATVLHGCRCVTNEMEMNASFRSSVERAEQLIAN
>NZ_CP025931.1|WP_148271453.1|6959_7262_+|DUF1661-domain-containing-protein
MLRKTWRENFFVLVPQVFISRAKTKNFTRVFFRIYEPQSRYFRFENQVSNKPQTSIAPLCNSKSVTAGSSGSKKLFSCYRSRTESLCRAIGTSPSWPVRD
>NZ_CP025931.1|WP_013815108.1|7401_9981_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MAYDFTQTFRNSLEYSYQEATRLGVVAVTQDMLVLGIIRDGDNGAIDIMRHYGINLYELKRLIELEAIAESLPASPEGSPIFTPSAREAINDATDICADMEDEAVSPVHLLLSILNSTQESLVQKIFMKQGIKYDTILSDYFGQRNPSEGKSPSEMEILDGYQDNDFDDEEDESSPPSGNGGAGRGSGDAPEQNTGGGDTTTTTRSGGDTPALDTFGTDITAMAAAGKLDPVVGREQEIERVIQILSRRKKNNPVLIGEPGVGKSAIVEGLAERIVNRKVSRILFDKRIISLDLAQMVAGTKYRGQFEERLKAVLDELKKNPQIIFFIDEIHTIVGAGSAAGSMDTANMLKPALARGQIQCIGATTLDEYRKNIEKDGALERRFQKVPIAPSTAEETLTILQNIKEKYEDYHGVRYTDEAIKAAVELTDRYVSDRFFPDKAIDAMDEAGASVHITNVVAPKEIEILEAELTSVRENKLSAVKAQNYELAASFRDQERRTQQQIAEEKKKWEDQMSKHRETVDENVVAHVVALMTGVPAERLSTGEGERLRTMADDLKTKVVGQDTAIEKMVRAIQRNRLGLRNEKKPIGSFLFLGPTGVGKTYLAKKLAEYLFEDENAMIRVDMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTERVRRKPYSVVLLDEIEKAHADVFNLLLQVMDEGQLTDSLGRRVNFKNTVIIITSNVGTRQLKDFGQGIGFHSEKDEEANKEHSRSVIQKALNKTFSPEFLNRLDDIILFDQLGKTEIRRMVDIELKSVLARIHRAGYDLVLTDEAKDVIATKGYDLQYGARPLKRTLQNEVEDRLTDLILSGQIEKGQTLTLSARDGEIIVQEQA
>NZ_CP025931.1|WP_013815109.1|10120_13132_+|serine-hydrolase
MKRFLFSAITILSLSVLYTATAPARTNMGAMHAQQSKDYPFLLFGGVDSKDVKRWVDDRMKAMSTEEKVGQLLMPIVYPSLQEEKVKQAEQLVRTCHIGGILFQKGTLSEQYTMTRRLQEAAGTPLLIALDGEWGLHMRLKDAPRFPRNMGLGHQKDNQLLYNYGREVARQCRLMGIHINFAPVLDVNNNPKNPVIGTRSFGDNPRRVAERGIAYAQGLEDGGVMAVAKHFPGHGNTTEDSHKTLPTVFASREELENTELFPFKEFFRAGLSGVMTAHLNVPALEAKKNTPSSLSHAICTDLLRQEMGFKGLIFTDGLAMQGVQTAGSQPISVRAILAGNDILLGPVDPVKTFSEVLAAVEDRTISKELLDEKCRKILAFKYALIICKGVSKEVPAEEVVRQVNSREAERMSEDLWRASITILKNKKQFLPLSEENRIACVNLDGAASNTFTQELGLTSKDCYSYAKGSNSTRTQELLSKLKGYDAVIVTVRHTQPDWAGTFLHRLTEQNHTAIVFFTSPYVADRIPVAMDKARAIVVAYENVKEAARMAAYKIRDRVVVSSGGGIPVVQEEEDTDPTANMMPPTELSSGLIPMPAVDRIAKEALRQGAFPGCRILAVHRDKVVYDKSFGTLDGSARGGKVSSSTIYDLASVTKVVATTPAVMLLVQDGKLKLSDRLGTLLPRFARTDLKDITVQQLLLHEAGLRPSINFYESLIDSSSLDGKLLSPRRSSGWVRVDTNMWGNPFFGFRSDLVSGQFRPDYPFRFSSNLYLSKEVKEIVLNTIASTPRNGVGRYKYSDLGFILLQQIVEKVSGKSLNVFVEERIFRPIGAGSLGYLPLDKYSVSRIAPAQNDKFLRKSIVRGTVDDEAAACLGGISGNAGVFGTAEDVARVLDMFIHEGTYKGHRIIDQKIFRQFITTHGKGNRRCLGFDKGRASMAESASGSTYGHTGFTGTCVWVDPESELIFVFLSNRTYPNRLNKTLMTASIRPRLHQAIYEALGIAEQ
>NZ_CP025931.1|WP_004583413.1|13179_14208_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MIFGHGDEGITPLSSEIVNFSTTVWTDGDKDHLEKHLVENLNCIRHYPEPDAGTLRQMLAKRNSVDNNAILVTNGPTAAFYQIAQAFRGSRSLIAIPSFAEYEDACRMYEHEVCFYPSNEDIGEADFSNMDFCWLCNPNNPDGRLLQRTEILRLLNDHPDTTFVLDQSYVSFTTEEVIRPADIKGRKNLVMVYSFSHAYGIPGLRIGYIVANKDFMKRVAAFSTPWAVNALAIEAAKFILIHPAQFTLPIRKWQRNTVDFITALNRLDGVEVHPSGTTFFLLRLKKGTAAELKKYMLEEYNMLIRDASNFRGLDESYVRITTQRPAQNQLFIKALETFLEKY
>NZ_CP025931.1|WP_013815110.1|14217_14988_+|2-phosphosulfolactate-phosphatase
MLQISLCPSPVLYPYYKTEQEEYTVVIVDIFRAGTTITTALMNGAVGIIPIATVEEAEIYAGNGFLVGGERGTKRLPFAHFGNAPEEYTRQAVEGKQLVLSTTNGTRAVDIAAGALHVIIGAFINLEAVARYCIAKQKPVMVLASGWQNRMSTEDCLFAGALAATIVRLGEEVICEDGASVFQELWGNYNTHEKLTAYLNGRDHYERLRANKLERSVPYCTSLNLTEIVPEMTFKISAASTDCPANRLFLPVTPPF
>NZ_CP025931.1|WP_013815111.1|15532_16882_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MKKSGNIIVVDDNKHVLTALKLLLTGSFETVTLLPSPKTLLSTIVEVHPDVLLLDMNFSTGINTGNEGLYWLDQVRSRFPDLPVVLFTAYADIRLAVEALKRGASDFVVKPWNNAELLESLRMAMNKAASTQVTATPKEDDSVFLGKSKAMCEVLELADRIGDTAAHVLITGENGTGKGVLAEYIHARSPRSRQPMLTVDMGALSETLFESELFGHVKGAFTDAKSDRAGKFETASGGTIFMDEIGNLSLALQAKLLAVLQQKVVTRVGSNTPIPVDVRIISATNSDLPLSVAEGRFREDLLYRLNTIHIEMPPLRRRREDIVPMAVFFLHRYARQYGKEVPELTPEAEALLSDYPWPGNVRELQHCIEKAVILSRSSSLSAADLSLPKSVDAHPTATGVASTPQTLDEMEKTAIKQALARNGSNLSNVARELGISRQTLYNKMKRYGL
>NZ_CP025931.1|WP_013815112.1|16892_18230_+|GHKL-domain-containing-protein
MGRRKTGSFGLHLLFTIVMAVVGTWSAAAGHYAITVFAAGLVIFSALRLRLLYRRHLQDLSLLLNAIENGDYSVRFSEMGGNVSHRTFNRTLNRIKEILSRSRDEAIAGEQFLVHVLEQIPVGIMMVAPEGYVYSTNTVLLRLLGLPVITHLDQLRRVSPDMPRLFRSAATDSGIHIKLTTEREEQEVSLRFSSFRIREKIYHIYTLSNIGKELDARETESWIRLIRVMTHEIMNSIAPITSICDTLLDNLQSSADEEMLSTGLDTIRSTGVGLLSFVQDYRKFTAVPPPEKEDIALYAFLSGILRLQEELLSSNDIKVDIEEIPVELTVPADRRQLTSVLTNLVKNAAEAEYPADTEKRLLRIRAEERLDSLDEHRLLFHVENNGTPIPQEVFDNMFVPFYTTKTGGSGIGLSLSRYIIRLHGGNLLARRTADGFTSFVIELPL
>NZ_CP025931.1|WP_043889966.1|18233_20480_+|hypothetical-protein
MRKPIVRFLLSFFWLLGVCASHMVGQSLPSVSKEIRELSNRTEQQTSLFDRKESEAFALETVRMISDRTPFLFRLAEGRSWEADVRGRSWASRVLPIVHRLKHGGIPWEQYLSSDSLCMEARLYGKYDSVTGAYKRGVVSFRSDIPQRNKVDDLTALALLGENVYAEEFDFGNRQIFPNPIRREAEAFYTYRLDSLYEKDGITYRRIAFRGLSGLNRGTVTIDATHGQLAILEMRVMMKGVITESYRVELGEVEPGLFLPIGLSVVIDRNRLWASLHNGYSASISYTGEQLDKTVLFVYMPTDSSRYRLPDELPVASVWAVRSSFGREDSSTYWKNVVVGRDHTLHQHVPWHRALAWGHKYRIGERWRLGNEGLVWALFYYNYADHLWLGQSLTAIYDMAPGIRWEIKPGLYYVTKRRKAVWTLDSKLYYSPPQRGLLQLSAGHRSFDLYSTRERIDQLTDLMMELLNGQGPTTRYDDKFVRLTNSIDLLPKLNVETSVMLAERNPLPHGETWSLFGGSITDILNISNADPDLPRIVPHHRLLEVRAKMTFNPRPYYRYTADGFLIREGEGIRAPLLSLSYRGAFGMGRKSDARFHHLDLSIQQRLVFSPAASLFYQLNVGGYFDRSVIYPSEYFFLKGGNAFWRFGDSMEAAFQTLPPYTATADKHLILQTSYRASRLLVNFLPFVFLKTNDEALHFKARWNMVSRKPYLEMGYSESIGTLMQVGVFYGGYNFFYERGVAIRFTFNM
>NZ_CP025931.1|WP_013815114.1|20564_21260_+|winged-helix-turn-helix-transcriptional-regulator
MKYKKLLFDLIDYLDAFESLHDGGSHEPEIKDFADFLSWRCGKKKKQEEEVVSVTRERAAGAKNIARGVSLLHRYSRFYIKKALTKSPLQTEDEYTYLVSLMNGESMTKTELNNLNAMEKTSGAEVMRRLLKANLIEQRPDEEDRRSMRVSITPEGRKVLVNLFPNLRLCAETLVSALSDEQLTAFDHLLWLLCECHNEMFTGKHDAELTDLHAETCGLKQSAGGALSKRL
>NZ_CP025931.1|WP_013815115.1|21254_22256_-|tRNA-dihydrouridine-synthase-DusB
MKIGAIDLGVEPLLLAPMEDVTDVAFRIMCKQFGADLVYSEFLSADALIRQVAGTFRKMAIDESERPMAVQIYGRDVASMVEAARLCESAGPDLIDLNFGCPVKRVAGKGAGSGMLRNIPLMIEITREVVKAVKLPVTVKTRLGWDNDSKIIVDLAEQLQDCGIAALTIHGRTRAQMYTGTADWTLIGEVKNNPRMQIPIIGNGDVTTPQEARRAFDVYGVDAVMVGRASIGQPWIFEDMKHFLRTGETLPSRPFSYYMDILRRQTLNNIRKLDERRGILHTRRHIAASPIFKGIPNFKPMRVAMLRATTQEELFALMDEVEKMIGSADSAAL

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Crispr_ID: NZ_CP025931_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_2

114674-114907

TypeVI-B2,TypeVI-B1

VI-B2

Consensus_repeat	Method
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	PILER-CR
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	CRISPRCasFinder
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	CRT

3 spacers

Csx28,cas13b

The CRISPR arrays of NZ_CP025931_2

>merge|NZ_CP025931|2|114674-114907|PILER-CR,CRISPRCasFinder,CRT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAACGATGTGGCTGTAGATGCACTCTTCCGCAAAGTTGGATCTACCCTCTATTCGAAGGGTACACACAACGAAGTGGCCAATGTTCGATAGGCTGCTCAGGTTGGATCTACCCTCTATTCGAAGGGTACACACAACACTGCCATATTATATAAGTGTGATTATTTTGTTGGATCTACCCTCTATTCGAAGGGTACACACAAC

>NZ_CP025931|2|1|114674-114907|PILER-CR
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GATGTGGCTGTAGATGCACTCTTCCGCAAA
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GAAGTGGCCAATGTTCGATAGGCTGCTCAG
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	ACTGCCATATTATATAAGTGTGATTATTTT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC

>NZ_CP025931|2|2|114674-114907|CRISPRCasFinder
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GATGTGGCTGTAGATGCACTCTTCCGCAAA
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GAAGTGGCCAATGTTCGATAGGCTGCTCAG
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	ACTGCCATATTATATAAGTGTGATTATTTT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC

>NZ_CP025931|2|1|114674-114907|CRT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GATGTGGCTGTAGATGCACTCTTCCGCAAA
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GAAGTGGCCAATGTTCGATAGGCTGCTCAG
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	ACTGCCATATTATATAAGTGTGATTATTTT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_013816156.1\|113918_114464_+\|hypothetical-protein	Csx28	-	unknown
NZ_CP025931.1\|WP_043890087.1\|117087_118557_-\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|277318
NZ_CP025931.1\|WP_004584828.1\|118559_119153_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_012458422.1\|103449_103968_-\|DUF4496-domain-containing-protein	unknown	unknown	gnl\|CDD\|273496
NZ_CP025931.1\|WP_004584817.1\|106847_107756_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP025931.1\|WP_013816161.1\|123035_123806_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223710
NZ_CP025931.1\|WP_012458402.1\|127430_127616_-\|DUF1661-domain-containing-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_080580311.1\|125922_127365_+\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP025931.1\|WP_013816162.1\|123900_125358_-\|internalin	unknown	unknown	gnl\|CDD\|380191
NZ_CP025931.1\|WP_013816153.1\|107766_108726_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NZ_CP025931.1\|WP_013816159.1\|119868_120897_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP025931.1\|WP_013816157.1\|115725_116925_-\|methionine-gamma-lyase	unknown	unknown	gnl\|CDD\|168478
NZ_CP025931.1\|WP_012458423.1\|102421_103417_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013816155.1\|110554_113914_+\|hypothetical-protein	cas13b	cas13b_CAS_V-B1	gnl\|CDD\|380475
NZ_CP025931.1\|WP_004584829.1\|119253_119859_+\|YihA-family-ribosome-biogenesis-GTP-binding-protein	unknown	unknown	gnl\|CDD\|234770
NZ_CP025931.1\|WP_043890086.1\|101478_102381_-\|glutamate-formimidoyltransferase	unknown	unknown	gnl\|CDD\|226169
NZ_CP025931.1\|WP_013816160.1\|120939_123036_+\|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl\|CDD\|236794
NZ_CP025931.1\|WP_013816154.1\|108778_109681_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_CP025931.1\|WP_013816152.1\|104643_106620_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NZ_CP025931.1\|WP_004584821.1\|109697_110267_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_043890087.1\|117087_118557_-\|metallophosphoesterase-family-protein	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.20368e-14
NZ_CP025931.1\|WP_012458422.1\|103449_103968_-\|DUF4496-domain-containing-protein	gnl\|CDD\|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	1.34591e-52
NZ_CP025931.1\|WP_004584817.1\|106847_107756_+\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.48889e-12
NZ_CP025931.1\|WP_013816161.1\|123035_123806_+\|HAD-IA-family-hydrolase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	6.85412e-38
NZ_CP025931.1\|WP_080580311.1\|125922_127365_+\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	4.09442e-93
NZ_CP025931.1\|WP_013816162.1\|123900_125358_-\|internalin	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.77428e-35
NZ_CP025931.1\|WP_013816153.1\|107766_108726_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	4.31474e-97
NZ_CP025931.1\|WP_013816159.1\|119868_120897_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP025931.1\|WP_013816157.1\|115725_116925_-\|methionine-gamma-lyase	gnl\|CDD\|168478	PRK06234, PRK06234, methionine gamma-lyase; Provisional.	0
NZ_CP025931.1\|WP_004584829.1\|119253_119859_+\|YihA-family-ribosome-biogenesis-GTP-binding-protein	gnl\|CDD\|234770	PRK00454, engB, GTP-binding protein YsxC; Reviewed.	2.70082e-98
NZ_CP025931.1\|WP_013816155.1\|110554_113914_+\|hypothetical-protein	gnl\|CDD\|380475	cd20477, Cas13b_Pb-like, Class 2 type VI-B CRISPR-associated RNA-guided ribonuclease Cas13b from Prevotella buccae and similar Cas13b proteins. CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) adaptive immune systems defend microbes against foreign nucleic acids via RNA-guided endonucleases. These systems are divided into two classes: class 1 systems utilize multiple Cas proteins and CRISPR RNA (crRNA) to form an effector complex while class 2 systems employ a large, single effector with crRNA to mediate interference. Class 2 type VI CRISPR-Cas13 systems use a single enzyme to target RNA using a programmable crRNA guide and are divided into four subtypes based on the identity of the Cas13 protein (Cas13a-d). The Cas13 proteins are capable of both pre-crRNA processing and target RNA cleavage, which protect the host from phage attacks. Once bound to a target RNA, their non-specific RNase activity is activated. Cas13b has many distinctive features compared to the other Cas13 proteins, including the lack of significant sequence similarity, disparate crRNA repeat region, and double-sided protospacer flanking sequence (PFS)-dependent target RNA cleavage.	0
NZ_CP025931.1\|WP_043890086.1\|101478_102381_-\|glutamate-formimidoyltransferase	gnl\|CDD\|226169	COG3643, COG3643, Glutamate formiminotransferase [Amino acid transport and metabolism].	1.54603e-150
NZ_CP025931.1\|WP_013816160.1\|120939_123036_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP025931.1\|WP_013816152.1\|104643_106620_+\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NZ_CP025931.1\|WP_013816154.1\|108778_109681_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.69251e-125

>NZ_CP025931.1|WP_013816156.1|113918_114464_+|hypothetical-protein
MMTMTICWTPICVQLIKLSGIFIAAYLAYRYAVRKLSLESIENIERCKYQAVLEAHRSFYKLLRFTTDTENADSILVWQKAKGGGAKTYYFRPACIRGFLSELTDEFYKNGNGIFLSKEIISRIFEYRSIVYGLLLSERQNSDERIVMNKPETAERMISIHQELTQTVREAIALKKRTLNF
>NZ_CP025931.1|WP_013816155.1|110554_113914_+|hypothetical-protein
MTEQNEKPYNGTYYTLEDKHFWAAFFNLARHNAYITLAHIDRQLAYSKADITNDEDILFFKGQWKNLDNDLERKARLRSLILKHFSFLEGAAYGKKLFESQSSGNKSSKNKELTKKEKEELQANALSLDNLKSILFDFLQKLKDFRNYYSHYRHPESSELPLFDGNMLQRLYNVFDVSVQRVKRDHEHNDKVDPHRHFNHLVRKGKKDRYGNNDNPFFKHHFVDREGTVTEAGLLFFVSLFLEKRDAIWMQKKIRGFKGGTETYQQMTNEVFCRSRISLPKLKLESLRTDDWMLLDMLNELVRCPKSLYDRLREEDRARFRVPVDILSDEEDTDGAEEDPFKNTLVRHQDRFPYFALRYFDLKKVFTSLRFQIDLGTYHFAIYKKNIGEQPEDRHLTRNLYGFGRIQDFAEEHRPEEWKRLVRDLDYFETGDKPYITQTTPHYHIEKGKIGLRFVPEGQHLWPSPEVGATRTGRSKYAQDKRFTAEAFLSAHELMPMMFYYFLLREKYSEEASAERVQGRIKRVIEDVYAVYDAFARDEINTRDELDACLADKGIRRGHLPRQMIGILSQEHKDMEEKIRKKLQEMMADTDHRLDMLDRQTDRKIRIGRKNAGLPKSGVIADWLVRDMMRFQPVAKDTSGKPLNNSKANSTEYRMLQRALALFGGEKERLTPYFRQMNLTGGNNPHPFLHETRWESHTNILSFYRSYLKARKAFLQSIGRSDRVENHRFLLLKEPKTDRQTLVAGWKGEFHLPRGIFTEAVRDCLIEMGLDEVGSYKEVGFMAKAVPLYFERACKDWVQPFYNYPFNVGNSLKPKKGRFLSKEKRAEEWESGKERFRLAKLKKEILEAKEHPYLDFKSWQKFERELRLVKNQDIITWMICGDLMEENKVEGLDTGTLYLKDIRTDVQEQGSLNVLNRVKPMRLPVVVYRADSRGHVHKEQAPLATVYIEERDTKLLKQGNFKSFVKDRRLNGLFSFVDTGALAMEQYPISKLRVEYELAKYQTARVCAFEQTLELEESLLTRCPHLPDKNFRKMLESWSDPLLDKWPDLHRKVRLLIAVRNAFSHNQYPMYDEAVFSSIRKYDPSFPDAIEERMGLNIAHRLSEEVKQAKETVERIIQA
>NZ_CP025931.1|WP_004584821.1|109697_110267_-|hypothetical-protein
MVFNFLIVSDEVEDFRREIAIDSEATFLDLQNAILDSVGYSHSELTSFFLCDEDWHKGQEITLMEMDTASDEDSYVMENTRLEEFIEDEHQRLVFEFDLMTERYFFIEVMDIVPGKSLSEPKLLTSEGLPPQQSSLDDLMDPTAIPTKQARGLDLEEDFFGDSEYNEDEIDREGFEGFDEITSDLSDNY
>NZ_CP025931.1|WP_013816154.1|108778_109681_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
METQDHTLYVLLGPTGVGKTDLSLDIAERLGSPIISADSRQIFRELPIGTAAPTPEQRARVPHLFVGTHSVRDYYSAGMYEVEVLEALKELFRKYRGVLLTGGSMMYIDAVCRGIDDIPDPFPEVREELYARYGAEGLDGILAQLRLLDPDYYAKVDRRNYKRVIHGLEICLSTGRPFSSFHRHEAKERPFRIVKIGLYREREELCKRIDARVLEMMEQGLEEEARAVYPLRHLNALNTVGYKEMFEYFDGSIDQAEAVRRIQRNSRVYARKQMTWFRHDSTIRWFHPEADKGTVLTLVT
>NZ_CP025931.1|WP_013816153.1|107766_108726_-|glycosyltransferase-family-2-protein
MDVNTTYTKELSIIVPIYNEERELPELVRRLSAAAASITEDYELIFVNDGSRDGSLELLRSLCKGDDRFFYINLSRNFGHQIAVSAGLDHVRGKATVIIDGDLQDPPELIPELYAKYREGYEVVYAQRKHREGETWFKKATAKGFYRTMRKITSIDMPLDTGDFRLIDRKIVQCLREMPEQNKFLRGQIAWMGFRQTGVQFDRDERKYGQTNYPLRKMLALAIDGITGFSSRPLEWVAQLGAWVSLLSLFVIVYALISHFLLDKTVSGWTSVIVSSMFLGGVQLICLGVIGTYISKINKNIVARPLYLVAESNIAADER
>NZ_CP025931.1|WP_004584817.1|106847_107756_+|DMT-family-transporter
MTSSRLYGLAVGILSSATFGLIPLFTLPISAKGASFELILFYRFFFAAIAIGILHRLSGGSFKVSRADIGPLVLLGFLYAGTALFLFHGYGYMASGVATTIHFLYPLFVTALMLLFFGERLSPVPLTAIFIALIGVGLLMGLTGGGDRVGLTGFVIVAISALCYALYIVFVNRSRIRIMPGRRLTFYVFVAAAGFCLINVLVRQGEVAPLPDAASWGNILLLALVPTVISNLALVVAVRNIGSTLTSALGAMEPLTSVLVGVWVFDEVLGASAIVGMGCILIAVGLIVFSEPLELMLRRRRR
>NZ_CP025931.1|WP_013816152.1|104643_106620_+|transcription-termination-factor-Rho
MQKYTIVDLNEKAEAELAAIAGELGIANAGSMPKQELIYKILDEQAISVAGVRKEKQKTTEDRHTERRKPGRPRKNAEEEAPESKDVAAAPAEPNEEEAQAKRKRGRPRKAAEEIAEETREDVQQLVALAAAEETNATEKESAGRKPAAKTSTASPAKAPAKALPRPAETTPRVAPSPPSTTPVSEPAKDDAKPETPAPPPAIESITTTPAAGAVDEGGARRLVFRHKNSSSVLDQVLPYSSPQPPQRPKPAGAPVGSSPIRQRQAAGVPTPRREPQQSLYNFDGILECMGVLEIMPDGYGFLRSSDYNYLSSPDDVYVSQQQIKHNGLKTGDVVAGTIRPPREGEKYFPFVQLRSVNGRSPEEIRDRVPFDHLTPLFPEEKFTLEAPGIRAVNDKISVRVVDLFAPIGKGQRGLIVSQPKTGKTMLLKDIANAIAANHPEVYMIVLLIDERPEEVTDMARSVNAEVIASTFDEPAERHVKIAEIVLNKAKRMVECGHDVVILLDSITRLARAYNTVQPASGKVLSGGVDANALQKPKRFFGAARNIENGGSLTILATALTDTGSKMDEVIFEEFKGTGNMELQLDRRLSNKRIFPAVDIMSSSTRRDDLLQDETTLNRMWILRKYLSDMNPVEAMEFVRKQLENTHTNMEFLASMSN
>NZ_CP025931.1|WP_012458422.1|103449_103968_-|DUF4496-domain-containing-protein
MSLKYVIKKSVAKIGPKAGQTIYYAQPAAQDSVTFHSLCKRIAEESALTSADVKGILDRLVNILSEELPNGKTVRIGELGSFRLSFGSKQLDDPKNFSVDQIQKHRLVFIPSAELKSIPARGKLRPGSSALAFDYERVEPQPKKKPGTGDNQTPSPSTPGGGGGQGGTGGGL
>NZ_CP025931.1|WP_012458423.1|102421_103417_-|hypothetical-protein
MFRISRLGIVLLVSLIACNLSKAQNTTKDLINLSIKYLEQNDSTAFRKTYQDIFMQYVTEALCAPFDKAIQDRDQTYIQARLDSLTSDPEEDAFTYHLLSKPEYQAFYYTLPRWEVYKSWIDSVERNPHADMRNEIWQIQREDQGIRILWLRLPNETGDNIRKKVRDEILLVDRQNTERAIHIIDTFGEWPGANRLGCSADQTLWLCIQHADQRPEVATRYLPMLQKAVEEKRTDPMHYAYLVDRIRMHECKEQIYGTQTYHVKEENGNKFFFVIPIEDIDHVDERRAGIGMDPLSDYVNSMGYDWDIRQYKKDLPKIWKYYRHSCKKKKN
>NZ_CP025931.1|WP_043890086.1|101478_102381_-|glutamate-formimidoyltransferase
MALSRIMECVPNFSEGRDREKIEKIVNPFRTREGVKLLNYSNDEDHNRLVVTVVGEPEPLREAVLEAVGIAVELIDLTKHTGQHPRMGAVDVIPFIPIKNVTAEDADALAKEVGRTIGEKYGVPVFLYEKSATAPHRENLAKIRKGEFEGMAEKIHEADWHPDFGPADRHPTAGTVAVGARMPLVAYNVNLNTNDLSIADAIAKKVRFLGGGLRFCKAMGVELTDRGIVQVSMNLTDFTKTAVYRAHEMVRMEAARYGVSVVGSEVIGLVPMQALIDCAEYYLGIENFSMDQILESRIME
>NZ_CP025931.1|WP_013816157.1|115725_116925_-|methionine-gamma-lyase
MKKEDLMRSGFATRAIHGGAIENAFGCLATPIYQTSTFVFDTAEQGGRRFAGEEDGYIYTRLGNPNCTQVEEKLAMLEGGEAAASASSGIGAISSAIWVCVKAGDHIVAGKTLYGCTFAFLTHGLSRYGVEVTLVDTRHPEEVEAAIRPNTKLVYLETPANPNMYLTDIKAVCDIAHKHEGVRVMVDNTYCTPYICRPLELGADIVVHSATKYLNGHGDVIAGFVVGKEDYIKEVKLVGVKDLTGANMSPFDAYLISRGMKTLQIRMEQHCRNAQTVAEFLEKHPAVEAVYFPGLPSFPQYELAKKQMALPGAMIAFEVKGGCEAGKKLMNSLHLCSLAVSLGDTETLIQHPASMTHSPYTPEERAASDISEGLVRLSVGLENVEDIIADLKHGLDSLI
>NZ_CP025931.1|WP_043890087.1|117087_118557_-|metallophosphoesterase-family-protein
MRKKRSNPYYKVSRRKFSKRNSGRRYSRKRRRNGRRWGLMISLLLLVALGIWIAKRYRAWFVSPAEVAYTVPHTIDRLTLTPGEDFLTQRTVSWRCDTLPQDSWLDYRSPDGADADTLLISLPAEGKEVLTRAGRNYYYHAKINGLKPGRTYTYRVKTGEQTSPWYRFSIPDSSAATDFIYIGDVQDPGNGGSQALLQQLRTLHPNPDFLALGGDQIEGPTDFYWEVWHRVIGDWTASTPVIAATGNHEYIKGLKRQLDPRWVPQYNYPANGPKGFERRSYYIDFPHMRLIVMDTNDIQWPASVFNHRTWLKNALETTVQPWKVVMFHHGVYSVRQGRMNPIIRYGFRSILEEGGADLVLQGHDHAYSRITTKTESGTKTTPVYIISSASPKHYRNGFSEQHDRIGSGLYLFQTIHVTQGEIRYRSTTFDNRPYDDLHLKKQGGRTTVKDNAEDWKEIFAFDNFADSKKGRKKRADYRQAAKERAAGHR
>NZ_CP025931.1|WP_004584828.1|118559_119153_-|hypothetical-protein
MNKSLIILIYTLVWVLLIVLQSLALESANPGTPSFWNTPSAYYSVWIVDAYIIALYYINYFLIAPFMIKRHLFRPYIVLSLALGGIGMLLPVVFHHAWQWTIPGTSEGQMPLYGEGFIASIAAIAVGLSVRGVREWVRLARRNTNLEIALKNKSIAYDRAEARLRSLEQPVSFHNPGTGAKAENAPSSTPVSPQTNE
>NZ_CP025931.1|WP_004584829.1|119253_119859_+|YihA-family-ribosome-biogenesis-GTP-binding-protein
MEIKKAAFVISNTDVRKCPDTRLPEYAFIGRSNVGKSSLINMLTGQKGLAMTSQKPGKTQLINHFIIDDSWYLVDLPGYGYARLGASNRESLRRIIETYILCREQLSSLFVLIDCRHEPQKIDLEFLQWLGENGIPFGIVFTKADKLSFSRLKENTEAYKQKLLETWEELPPVFITSSEKKTGKEELLDYIDSINQELATK
>NZ_CP025931.1|WP_013816159.1|119868_120897_+|UDP-glucose-4-epimerase-GalE
MKQKILVTGGTGYIGSHTTVELQQAGYRVVSVDNFSNSNAAVLDGIARITGVRPDFYEADCNDTEAMERVFTAHPDIAGVIHFAASKAVGESVQKPLLYYRNNILSLLNILELMERFGTRGIVFSSSCTVYGQPEVLPVTEEAPIQEALSPYGNTKQINEEIIRDAIHAGAGYKAILLRYFNPIGAHPTAHIGELPNGVPQNLIPYLTQTAAGIRAELSVFGDDYDTPDGSCIRDYIYVVDLAKAHVAAIERMLNEEKASDSLEVFNIGTGRGVSVLELIRTFERVTGVVVPHRIVGRREGDIEQVWAEPKKANEVLGWKALESLEDTLLSAWRWQQRLSVK
>NZ_CP025931.1|WP_013816160.1|120939_123036_+|ATP-dependent-DNA-helicase-RecG
MDILSTKITYLTGVGPKRAEVLKEEIEVRTYLDLLHYFPFRYVDRSRFYAIREIRSDMPYIQLRGVLRNFSEVGEGRRKRLTATFSDGTGSIELVWFKGIKYIRDKLQEGRRYIVFGKPVFFASGYNIAHPEIDAEEKAEQVAGGLTPIYHTTERMKSMGLGSKQLQQLLYVLLNQVSATLTETLPPYILSSYGFVSYQEAIRQIHFPQGVAQLEAARTRLKFEELFYVQLHLIGSKLERKARFQGIVFAQVGALFNTFYKEHLPFELTGAQKRVVREIRQDTLSGHQMNRLVQGDVGSGKTLVALLAMLLALDNGCQACLMAPTEILARQHHHTLSELLRPLGIEVGLLIGSCTARQRERLLPRLADGSLSIVVGTHALLEQGVAFRRLGMAVIDEQHRFGVQQRARLWEKNLDTLPHILIMSATPIPRTLAMTLYGDLDISIIDELPPGRKPIQTLHHFDSDMAPVFRFLRSQLAAGRQVYVVYPMIEGSETTDLKNLEDGFELFSSIFPDEGVTMVHGKMKAKEKEARMADFVSGRSRILLATTVIEVGVNVPNATVMVVENADRFGLSQLHQLRGRVGRGGEQSYCILITGTKTGEDSRRRIQVMVETNDGFEIAEEDMRLRGFGDLEGTRQSGRQISLRIANPARDTELIALSRSIAEQLLERDPELRHPDNQMLALRLNKLFPKEEDWSVIS
>NZ_CP025931.1|WP_013816161.1|123035_123806_+|HAD-IA-family-hydrolase
MEKKESMDYNNITEALQAFRTEKAYRHAPLRSCFFDMDGVLFDSMPAHARSWVEAAGECGIAAEPLDFYRWEGQKGSDTIKILFERGYGRLPTEKEIADMYGRKSQLFALYNSGSVIDDAPALVSDVCDRGLRIMLVTGSSQTDILQRLQRSYGDNFSPANMVTGADVHRGKPHPEPYLKALECVGMSPSEAFVVENAPLGVRAAVDAGIFTIAVNTGCLPDADLWDAGASLVLPSMAVLRSLLGELLTASLSSSA
>NZ_CP025931.1|WP_013816162.1|123900_125358_-|internalin
MKRKPLFSALVILSGFFGSVHPASAQKVPAPVDGERIIMELSEADVECTIKIEAEDGYANDIWADLNGNGKYDSGERLDSGEFRDVEFRQTKAIVYGKMAKFLFRGSSAGDYGATFIDISNCTGLTAFDCFANLLTELDLSKANGLTFVNCGKNQLTKLDLPANADIETLNCSKNKITSLNLSTYTKLKELYVGDNGLTALDLSANTLLEELVYSNNEVTTINLSANTNLKSLYCINNKMTGLDVAANKELKILHCNNNQLTALNLSANTKLTTLSFFNNELTNIDLSGNTALEWLFCNGNKLTKLDVSANANLIALQCSNNQLTALDLSKTPKLTTLNCYSNRIKDTAMRALIESLPTITEGEGRFVPYNDDEEGGEEENVCTTEHVEMAKAKNWKVLTSWGEPFPGITALISIEGESEYSVYAQDGILYLSGMEQGLPVQVYTVGGSMMYSSVASGSAMEIQLPRGAAYVVRIGSHAIKTAMP
>NZ_CP025931.1|WP_080580311.1|125922_127365_+|exo-alpha-sialidase
MYRTLVKVALSESLPPDAKQIRIGFSLPKETEEKVTALYLLVSDSLAVRDLPDYKGRVSYDSFPISKEDRTTALSADSVAGRRFFYLAADIGPVASFSRSDTLTARVEELAVDGRPLPLKELSPASRRLYREYEALFVPGDGGSRNYRIPAILKTANGTLIAMADRRKYNQTDLPEDIDIVMRRSTDGGKSWSDPRIIVQGEGRNHGFGDVALVQTQAGKLLMIFVGGVGLWQSTPDRPQRTYISGSRDEGLTWSPPRDITHFIFGKDCADPGRSRWLASFCASGQGLVLPSGRIMFVAAIRESGQEYVLNNYVLYSDDEGDTWQLSDCAYRRGDEAKLSLMPDGRVLMSIRNQGRQESRQRFFALSSDDGLTWERAKQFEGIHDPGCNGAMLQVKRNGRDQVLHSLPLGPDGRRDGAVYLFDHTSGRWSAPVVVNSGSSAYSDMTLLADGTIGYFVEEDDEISLVFIRFVLDDLFDARQ
>NZ_CP025931.1|WP_012458402.1|127430_127616_-|DUF1661-domain-containing-protein
MPEFSCLQFGKTWRVNFFALAREVKKSRTKTKKFRHHLLQKRRAAIRGFSARIGGIAVDGY

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Crispr_ID: NZ_CP025931_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_3

471563-471670

Orphan

Consensus_repeat	Method
GAAGCGATTTCGGCGAAAAAATTCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025931_3

>merge|NZ_CP025931|3|471563-471670|CRISPRCasFinder
GAAGCGATTTCGGCGAAAAAATTCCTTGCTGCAGCTTGCAGGAAGCTACTTTGGCGAAAAAATTCCTATTTGCAGCTTGCAAGAAGCGATTTCGGCAAAAAAATTCCT

>NZ_CP025931|3|3|471563-471670|CRISPRCasFinder
GAAGCGATTTCGGCGAAAAAATTCCT	TGCTGCAGCTTGCAGGAAGCTACTTTGGCGAAAAAATTCCTATTTGCAGCTTGCAA
GAAGCGATTTCGGCAAAAAAATTCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_013816405.1\|472013_474365_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|274576
NZ_CP025931.1\|WP_013816397.1\|461031_462102_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP025931.1\|WP_004585221.1\|463297_463891_-\|indolepyruvate-oxidoreductase-subunit-beta	unknown	unknown	gnl\|CDD\|180732
NZ_CP025931.1\|WP_013816408.1\|480203_481757_-\|DUF1858-domain-containing-protein	unknown	unknown	gnl\|CDD\|225301
NZ_CP025931.1\|WP_013816399.1\|463917_465525_-\|indolepyruvate-ferredoxin-oxidoreductase	unknown	unknown	gnl\|CDD\|274526
NZ_CP025931.1\|WP_012457723.1\|470110_471364_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP025931.1\|WP_013816413.1\|486258_486543_-\|NifU-family-protein	unknown	unknown	gnl\|CDD\|376458
NZ_CP025931.1\|WP_013816403.1\|468736_470071_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_CP025931.1\|WP_013816398.1\|462145_462904_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP025931.1\|WP_013816411.1\|483791_484907_-\|4-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|341482
NZ_CP025931.1\|WP_013816400.1\|465602_466364_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187604
NZ_CP025931.1\|WP_013816410.1\|482240_483596_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143440
NZ_CP025931.1\|WP_125026627.1\|466464_466629_-\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_013816407.1\|476793_479169_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|274576
NZ_CP025931.1\|WP_013816406.1\|474397_476767_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NZ_CP025931.1\|WP_013816409.1\|481876_482035_-\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_013816402.1\|468021_468534_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238493
NZ_CP025931.1\|WP_004585224.1\|466791_467985_+\|saccharopine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224662
NZ_CP025931.1\|WP_004585231.1\|479261_479921_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP025931.1\|WP_013816412.1\|484957_486253_-\|acetyl-CoA-hydrolase/transferase-family-protein	unknown	unknown	gnl\|CDD\|223504

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_013816405.1\|472013_474365_+\|FtsX-like-permease-family-protein	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	3.07712e-20
NZ_CP025931.1\|WP_013816397.1\|461031_462102_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.20854e-67
NZ_CP025931.1\|WP_004585221.1\|463297_463891_-\|indolepyruvate-oxidoreductase-subunit-beta	gnl\|CDD\|180732	PRK06853, PRK06853, indolepyruvate oxidoreductase subunit beta; Reviewed.	4.90894e-83
NZ_CP025931.1\|WP_013816408.1\|480203_481757_-\|DUF1858-domain-containing-protein	gnl\|CDD\|225301	COG2461, COG2461, Uncharacterized conserved protein [Function unknown].	6.50376e-105
NZ_CP025931.1\|WP_013816399.1\|463917_465525_-\|indolepyruvate-ferredoxin-oxidoreductase	gnl\|CDD\|274526	TIGR03336, IOR_alpha, indolepyruvate ferredoxin oxidoreductase, alpha subunit. Indolepyruvate ferredoxin oxidoreductase (IOR) is an alpha 2/beta 2 tetramer related to ketoacid oxidoreductases for pyruvate (1.2.7.1, POR), 2-ketoglutarate (1.2.7.3, KOR), and 2-oxoisovalerate (1.2.7.7, VOR). These multi-subunit enzymes typically are found in anaerobes and are inactiviated by oxygen. IOR in Pyrococcus acts in fermentation of all three aromatic amino acids, following removal of the amino group by transamination. In Methanococcus maripaludis, by contrast, IOR acts in the opposite direction, in pathways of amino acid biosynthesis from phenylacetate, indoleacetate, and p-hydroxyphenylacetate. In M. maripaludis and many other species, iorA and iorB are found next to an apparent phenylacetate-CoA ligase.	1.28548e-175
NZ_CP025931.1\|WP_012457723.1\|470110_471364_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.45071e-33
NZ_CP025931.1\|WP_013816413.1\|486258_486543_-\|NifU-family-protein	gnl\|CDD\|376458	pfam01106, NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	1.2279e-16
NZ_CP025931.1\|WP_013816403.1\|468736_470071_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	2.43713e-41
NZ_CP025931.1\|WP_013816398.1\|462145_462904_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.12852e-77
NZ_CP025931.1\|WP_013816411.1\|483791_484907_-\|4-hydroxybutyrate-dehydrogenase	gnl\|CDD\|341482	cd14860, 4HBD_NAD, 4-hydroxybutyrate dehydrogenase, also called gamma-hydroxybutyrate dehydrogenase, catalyzes the reduction of succinic simialdehyde to 4-hydroxybutyrate in the succinic degradation pathway. 4-hydroxybutyrate dehydrogenase (4HBD) is an iron-containing (type III) NAD-dependent alcohol dehydrogenase. It plays a role in the succinate metabolism biochemical pathway. It catalyzes the reduction of succinic simialdehide to 4-hydroxybutyrate in the succinate degradation pathway This succinate degradation pathway is present in some bacteria which can use succinate as sole carbon source.	0
NZ_CP025931.1\|WP_013816400.1\|465602_466364_-\|SDR-family-oxidoreductase	gnl\|CDD\|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.8236e-148
NZ_CP025931.1\|WP_013816410.1\|482240_483596_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143440	cd07122, ALDH_F20_ACDH, Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like. Coenzyme A acylating aldehyde dehydrogenase (ACDH, EC=1.2.1.10), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA . The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH and may be critical enzymes in the fermentative pathway.	0
NZ_CP025931.1\|WP_125026627.1\|466464_466629_-\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000952683
NZ_CP025931.1\|WP_013816407.1\|476793_479169_+\|FtsX-like-permease-family-protein	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	6.26143e-33
NZ_CP025931.1\|WP_013816406.1\|474397_476767_+\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	4.81462e-32
NZ_CP025931.1\|WP_013816409.1\|481876_482035_-\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.00538193
NZ_CP025931.1\|WP_013816402.1\|468021_468534_+\|isochorismatase-family-protein	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	2.64691e-32
NZ_CP025931.1\|WP_004585224.1\|466791_467985_+\|saccharopine-dehydrogenase-family-protein	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	3.02098e-158
NZ_CP025931.1\|WP_004585231.1\|479261_479921_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.00946e-113
NZ_CP025931.1\|WP_013816412.1\|484957_486253_-\|acetyl-CoA-hydrolase/transferase-family-protein	gnl\|CDD\|223504	COG0427, ACH1, Acetyl-CoA hydrolase [Energy production and conversion].	1.56665e-125

>NZ_CP025931.1|WP_012457723.1|470110_471364_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MDRKIEKKKTLIPRKYYPYAGGAIVILALAAWAVFGNHSTKFRAERARISIDSVRRGEFNDYVRINGQVQPINSIQISAVEGGMVAEKTVEEGAMVHKGDIIVRLTNPMLNLNILDSEAQLAEKQNFLRNTQVTMEQDRLNLKRESLNLRLDIERKKRKAEQYARLYKEKLCSREEYLQAGEDYQYAVEGSRLVMERQRQDSLYRGIQVRQMEESLHNMRRNLEMVRARVEDLNVKAPADGQLGLLDVEIGQTVGAGSRIGQINVLSDYKVEAMIDEHYIDRVKAGLAASFERQGRDFSLRVRKVYPEVRDKQFRTDFVFDGERPDNIRTGQTYYINLRLGQPSEAIMIPRGAFYQNTGGRWIFVVTPDGKRAVRRDITIARQNPQYYEVTSGLHAGEMVITSSYDMFGDAEEIILN
>NZ_CP025931.1|WP_013816403.1|468736_470071_+|TolC-family-protein
MRFQHYLICTAAVAALAANPLTGQSNMTLEECIDYARRHSSAVALSAAELEQSKADYLQAVGNFLPRVSAGTGASWNFGRGLDAETNTYTDINSFNNSYSIHATMTLFDGLQSVYRLRMAHARRESSRLSVREQQELAALGTTEAYYDLVYARQMQELAMQKYEESNRLHRQTARMEELGMKSRPDVLEMQSRMAGDRLTLTQADNQCIIALIRLKEKMNFPIDDELVLDDMPADSLSADMAESDSSAGVFARAAHHHPVLLRAKLDEQAATDRLRAARGAFLPSVSVSGGWNTGFSRFLNGSDYTPFSEQFRNRRGEYVSLNLSIPIFSGFSLVSNLRQARAERRAAIVRRGEAERRLYSEIAQAMADRDAALASYRQAKEHTDAMQTAYEAVLQRYEEGLNTAIDLTTQANRLLDARVQRLRAAMTYRLKCKLIAYYGCLSD
>NZ_CP025931.1|WP_013816402.1|468021_468534_+|isochorismatase-family-protein
MVLLIVDPQVDFVSGSLAVEGAPKAMKALAEYMAAHRKEIKSIVVTMDQHPADHCSFVAQGGQWPSHCVRYTVGAAIEPCIAEALAACSAEGIPVEMIEKATTQERDAYSAFETEVPDSLRSTERIVVAGIAGDYCVRQSVLDLERHGLGERIELLKEGIAYIAEEENRP
>NZ_CP025931.1|WP_004585224.1|466791_467985_+|saccharopine-dehydrogenase-family-protein
MGKVLIIGAGGVGTVVAKKVAMNTDVFTEIMLASRTRSKCDKIASEIKNVRIQTAQVDADNVEELVALFESFKPELVINVALPYQDLTIMDACLRCGVNYLDTANYEPLDEAKYEYSWQWAYQDRFRKAGLTAILGCGFDPGVTSVYTAYAAKHHFDEIHYLDIVDCNGGDHHKAFATNFNPEINIREITQKGKYWENGRWIETEPQEIHKTLTYPSIGERESYLLYHEELESLVKNFPTIKRARFWMTFGQEYLTHLRVMQNIGMTRIDPIMYNGVEIVPIQFLKAVLPNPGDLGENYTGETSIGCRIRGIRDGKEHTYYIWNNCSHEVAYKETGTQGVSYTTGVPATVGAMMFMKGIWRKPGVFNVEEFDPDPFLEEVAKQGLPWHEKHDIDLEL
>NZ_CP025931.1|WP_125026627.1|466464_466629_-|DUF1661-domain-containing-protein
MPCHKTWCVNFFVLVREVKNSRATTKKFSRHFVQKTRATIRSFAVRISDKTDPD
>NZ_CP025931.1|WP_013816400.1|465602_466364_-|SDR-family-oxidoreductase
MNPIALITGATSGIGAASARRLASLGYNLIITGRRSERLQNIADEIRAEYPVEILPLSFDVRNREEVETHLGNLLDPWQAVSVLVNNAGLAAGLDPIQSGDIEDWERMIDTNIKGLLYVTRTISPGMIARSAGHIINIGSIAGKEVYSNGNVYCATKHAVDALSKAMRIDMLPYGIKVTQICPGAVETEFSLVRFHDDQAKADAVYKGFTPLCANDIAECIAAVLNLPDNICINDMVVMPKAQAGSGHFFKQV
>NZ_CP025931.1|WP_013816399.1|463917_465525_-|indolepyruvate-ferredoxin-oxidoreductase
MQKQLLLGVEAIAQAALDAGISGVYAYPGTPSTEITEHIQNSRMAKERNIHREWAANEKTAMESALGMSYAGKRALVCMKHVGMNVAADCFMNAAITGANGGMVIVAADDPSMHSSQNEQDSRVYGQFAMIPVMEPSNQQEAYDMTRLAFDLSERLGTPVMMRITTRLAHSRAGVVQTEPIGENELHLPEDKRQYVLLPGIAKKRYRILLDKQTDFVRESENSPYTEYVDAADKSKGIVACGIAYNYLMEAFKAQVPYPVLKVTQYPIPHKQMERLLNECGDIVIMEEGYPVVEQLLKGFPGLERIKGRLDGTLPRDGELNPDHVAKAFNIPVVEGEPIPDLVAARPPALCKGCSHRDVYDALNEVLTEYPNGRVFSDIGCYTLGALPPYEAINSCVDMGASITMAKGAADAGLFPAVSVIGDSTFTHSGITGLLDAINENSNITVIISDNESISMTGGQHSSAYGKVEAICRGIGVDPDHIKELLPVPKNHDELCSIIREEINYEGVSVIIPRRVCIQKHARDAKAAKRAKAKE
>NZ_CP025931.1|WP_004585221.1|463297_463891_-|indolepyruvate-oxidoreductase-subunit-beta
MKTDIILAGVGGQGILSIAAAIGSAALTNNLYLKQAETHGMSQRGGDVQSFLRLSDAPIYSDLIPIGGADLILSVEPMEALRYLPYLKPDGYVVTNTVPFINIPNYPETTSVISKIESLPHHVLIDADSIARDEVGNVRASNFVMLGAASPFIEIPFDYLAGGIEAIFSRKGQEVVDMNLKALNAGREFALRYAAGK
>NZ_CP025931.1|WP_013816398.1|462145_462904_+|ABC-transporter-ATP-binding-protein
MEKSIELSRLAIGYRTKSGDRIVASGLEAHLHAGQLTALLGVNGAGKSTLMRTMAGFMKPLSGQIHLLGRSLDSYKEIEIAKRIGVVLTDNCRIAGMTAGELVALGRSPYTGFWGRLQKGDRKLVAEAVERVGIAPLINRELTTLSDGERQKVVIAKALAQQTPIIFLDEPTAFLDYPSKMELLYLLHSLAHDTGRTIFLSTHDLDAILPMADRVWLLDKERPFREGTPASLASALEDYFGYTHLSPTSEPV
>NZ_CP025931.1|WP_013816397.1|461031_462102_+|iron-ABC-transporter-permease
MTSVSHLRTISIAGILAALGGAVLILFGVNLFLGSVAIPMSEIFRHLFSDRPEGGEALVHYNILWKSRLPEALTAAFAGAGLSVSGLQMQTVFRNPLAGPSVLGISSGASLGVALVVLLSGSLGGVALSSLGYMGEVAMNIAAAVGSLAVMGLIVFVSTKVRSHVTLLIIGVMIGYVANAVIGVFKFFSIEEDIRAYVIWGLGSFSRATDSQLSFFAILMLIFIPAGMLLVKQLNLLLLGESYARNLGLNTRRARLLVISSAGLLIAAVTAYCGPIGFLGMAVPHLARVIFHTSDHRILMPATCLIGSALALFCNIIARMPGFEGALPVNSVTALVGAPIIVTVLFRRRRFKEETD
>NZ_CP025931.1|WP_013816405.1|472013_474365_+|FtsX-like-permease-family-protein
MRTYFKFLSRNKLYTFVTIVGFALSLIFVLLLSFYVRREQQADRIHTDYKRIYQYNVESKNNWSGFICCYPAGTLIREQVPDVEEICRISEYNDKEYIFIGADKQNGLIASHLSVESNFFTFFDGYKLLEGDPKTVLSEQNSAVISSALAARIFGNMSPIGQEISFFDFSKNKQTFRITGIMEPMPDNCHIRPAELLFYQEPKENNYNNGNYALYLKAREGADLTAQLPAVQKTVQGKDVIFAFDEKAEVKLHPLEKCYPEPLFPNEYAMMVQKGNPARTRILIAITLLVLIIAIISYINLTLAQGGSRGNEVALRRLWGSSRLAIVRRLWFESLLLIFLSTLLAVFGMFALEPVFDRLFDTHLYLARHISLTLILLLIGFMLLLSIVCAALPAWFISRFRPIEVVSGKFRRVVKSSFSQIMVISQYAITMILLSCTMVMAVQIDYMTNSDMGYDYRNKLIIDVFGLDPQIVSTMRTEIAKIPGITGIGLTRGTPLNGGNNNSSEYRGRPLSMQIFSIDSVALSLFDLKMKPNGRKADKPDRTLYLSRSAYNDFDVANLPDGVIHWGKAGEFYYCGDAPEVHFGGFKEPHPSYLFIPYPQSSAWSWSVLVGYSEGADPEQLIQSIQAVYSRITGQPYTEILRSEDIIASHSEEERSLSGFLLLFSILALVGTVMSVFAMAALRIRHKQKEIAIRKVVGAREVQILQIIGRRSLWNLLIAFAVASPASYLVMNRWLQGYTYHADMPWWVFPASLLFVSAVAMLSMLSMAMNAASSNPVDYLKNE
>NZ_CP025931.1|WP_013816406.1|474397_476767_+|ABC-transporter-permease
MRTYFKFLSRNKLYTFVTVFGFSVSLMFVILLGFYVQGELSVDNFHSKGDRIYMLRSELHACLSNPAPAYVQELVPEVEAYCRIANADLYIETTDGEKIKTSILLVDSTFFTIFDFKLRTGQPDDVLSLRRSIVLTPETARRFFGNDDPKGRILHDKLTVSGIMEPIPFYSQFPQVDAVVSYDYIEELFGSELLSGWGYFQFSAYFLMKPHTNIQAKAKVLEKIFTGEESPLGLWRSGYAKEVHFVPLKKCYYDPLVITSRFDIRKNDASKVYILLAIVLLILFIAILNYINLTVAQAGFRGKEAAVRRLLGESQKGLIRRYLGESFLITFISFLLGLLLAFILEPFFDRVLDTRINLISRFTYQTIIVIVSSIVILSFASGLLPSIVISHFKPIEVVKGYFSYRIKSNYSHFLVILQYTVSLILVTCSLIILMQSHFLIHTDLGFRTHGIMLISNNLDSVPQESLRNEIQKIPGVDMVSFSSGNPVNIANNVAFNDDGERAQFTWEMMIDSLFFDFFEIKPKYITQEPREVLFNGDRFRKTHLMPSWATASMVNVVHPDPNTHEFTRGSYKQYDGLTHVMVGILPEIKYRPLNESHDPLLIYPLQRGQYPWTTMVRVRDSIDRKAVEKTILETYKRIGNVDDVKWHWAEDIILDRYKSQTNLSQLISAFALLTVLIMVMGVFAMSLYMIKQKEKEIALRKVNGATVATILAMLNIRSLRRFGIALLIALPVSWWAMDRWLQTFAFHIRLDWWVFVVAALIVLLLSLVSTSLQSWRAACANPVDYLKNE
>NZ_CP025931.1|WP_013816407.1|476793_479169_+|FtsX-like-permease-family-protein
MLPLKLAARRLFRQGEHSISKLLTLTLGLSVSVLLLSIVIYQRSYERDFPHHDRICIVKTHGTRQSQEGDKPEELDFSQVSGGVAPAIQEEIPGVELATRTTLYGTSKMILEDNKTYETKTLLAEPAFLDMFGVELIAGVRDSALRDNMTCLISESLARKMGGDVLGKRLRPAESKSDRAITIGGVFEDLPHNSSIQADMLLPITWMPAESLNNWIGNDRYIAYVRLRPGVSPESLDEALLEMQKRHQDMEVFRKAGVELHYSLTPFNRLRLEDPTLVNMLRIQQIVAIAVLLISLLNYVLMTLASMVNRRRVAAIRKCYGAMPVQIQGTMIWETFLYLFLSLVLALLTLILFRKPMEALIETPLLHLISWRVAAALAGVLAMATFFMGWIPGYSLSRTPVMNIFRKSVAHNRLWKLGLLAVEFVAASFLFGLLAITGLQYRHMIGQDAGYKAAGLYYVPIESLDQQQLPVVIEKLKALPEVEGYTLTTALPASSGQSGDNLIDPVTDRELINVADLFYVDEHYLKVYDIELLEGKNFDAATEKDREIMLSKKAATELARLMNWKDGVIGKNIILTSFGRVVIRGVYDDLMLRRQHLSPYPEKLPSAIVYGDDWLHYLTIRLRHDDARLLHRVNGILSEADPYKETSFLSVEMELLSRFEAAKTFRNTILFGSVVAILIALIGLVGYVNTEVNRRRKELAIRKINGAGEGDILRLFLRSIFRLSLPSVLAGLFVAYLFGRNWLEKFSYRIELNGRIFLLVGLFVLLIIALAVVINLRRIARRNPVNELRYE
>NZ_CP025931.1|WP_004585231.1|479261_479921_+|ABC-transporter-ATP-binding-protein
MIEISNLTKVFRTEEIETVALDGVSLKVDKGEFIAIMGPSGCGKSTLLNILGLLDNPTSGIYKLDGAEVGNLREKDRTAVRKGNIGFVFQSFNLIEEMTVSENVELPLVYLGVKASERKERVEEALRKMSISHRAGHFPNQLSGGQQQRVAIARAVVANPKLILADEPTGNLDSKNGADVMELLRGLNREGATIVMVTHSEHDARSAGRIINLFDGKIR
>NZ_CP025931.1|WP_013816408.1|480203_481757_-|DUF1858-domain-containing-protein
MQDIKTNETFDSLDKSKLERMLDIKEAHREGHLTLEEAKERMKKEVGSISPEEFAAAEQLFKERDQDECQNEDVRTMLQLFEGLINPIRPDLPFGHPIDAYLRENDKAKELLDQADALLERTFIPNPWIELMETLMGYKLHFARKQNQLYSTLEQKGFDRPSTTMWTYDDHIRDEMNKAMSLLREKDYDSFPAAYKEMAIVLRDLMEKEELILYPTSLKLISDKEFEAMKHGDREIGFFLIDMPELDAPAKQSKEAHGQSFMAELGALLAKHGMGTGGQDDKAILDVAEGKLTLEQINLLFRHLPVDISFVDENELVCFYTDTKHRVFPRSKGVIGREVRNCHPPKSVHIVEEIIDKFRRGEQDRAEFWINKPGVFIYIVYVAIRDADGRFRGVMEMMQDCTRIRSLEGSRTLLTWDEEQSPAQGSKESESDTVGEDGIRPDTKLKSLLQRYPRLMDDLPTISSKFTLLRSPMAKVILPVATIKMMSERADIPSDMLIGKLESLIASYNKPDRSEEK
>NZ_CP025931.1|WP_013816409.1|481876_482035_-|DUF1661-domain-containing-protein
MNFLLLAWEKKKSETKTKKISRLLFTKYRPQSEHFRLVSCLRRNEHMHFFPR
>NZ_CP025931.1|WP_013816410.1|482240_483596_-|aldehyde-dehydrogenase-family-protein
MEIKEMVSLARKAQKEYQATHNQEAVDNICRAAAKVIYENAAILAREAVDETGMGVYEHKVAKNQGKSKGVWYNLHNKKSVGILNIDERTGMIEIAKPIGVVGAVTPTTNPIVTPMSNIIFALKTCNAIIIAPHPRSKKCSAHAVRLIKEAIAPFNVPEGMVQIIEEPSIEKTQELMGAVDVVVATGGMGMVKSAYSSGKPSFGVGAGNVQVIVDSNIDFEAAAEKIITGRAFDNGIICSGEQSIIYNEADKEAVFTAFRNHGAYFCDEAEGDRARAAIFENGAIAKDVVGQSVAFIAKKANINIPEGTRILVVEARGVGAEDVICKEKMCPVMCALSYKHFEEGVEIARTNLANEGNGHTCAIHSNNQAHIILAGSELTVSRIVVNAPSATTAGGHIQNGLAVTNTLGCGSWGNNSISENFTYKHLLNISRIAPLNSSIHIPNDKEIWEL
>NZ_CP025931.1|WP_013816411.1|483791_484907_-|4-hydroxybutyrate-dehydrogenase
MQLFKLKSVTHHFDTFAEFAKEFCLGERDLVITNEFIYEPYMKACQLPCHFVMQEKYGQGEPSDEMMNNILADIRNIQFDRVIGIGGGTVIDISKLFVLKGLNDVLDAFDRKIPLIKEKELIIVPTTCGTGSEVTNISIAEIKSRHTKMGLADDAIVADHAIIIPELLKSLPFHFYACSAIDALIHAIESYVSPKASPYSRLFSEAAWDIILEVFKKIAEHGPEYRFEKLGEMIMASNYAGIAFGNAGVGAVHALSYPLGGNYHVPHGEANYQFFTEVFKVYQKKNPFGYIVELNWKLSKILNCQPEYVYPKLDELLGCLLSKKPLREYGMKDEEVKGFAESVLKTQQRLLANNYVELTVDEIEGIYRRLY
>NZ_CP025931.1|WP_013816412.1|484957_486253_-|acetyl-CoA-hydrolase/transferase-family-protein
MKDVLAEYASRIVSAEEAVKHIKNGERVALSHAAGVPQSCVDALVQQADLFQNVEIYHMLCLGEGKYMAPEMAPHFRHITNFVGGNSRKAVEENRADFIPVFFYEVPSMIRKDILHIDVAIVQLSMPDENGYCSFGVSCDYSKPAAESAHLVIGEINRQMPYVHGDNLIHISKLDYIVMADYPIYSLAKPKIGEVEEAIGRNCAELIEDGATLQLGIGAIPDAALLFLKDKKDLGIHTEMFSDGVVELVRSGVITGKKKTLHPGKMVATFLMGSEDVYHFIDKNPDVELYPVDYVNDPRVIAQNDNMVSINSCIEVDLMGQVVSECIGSKQFSGTGGQVDYVRGAAWSKNGKSIMAIPSTAKNGTTSRIVPIIAEGAAVTTLRNEVDYVVTEYGIAQLKGKSLRQRAEALIAIAHPDFREELTEHLRKRFG
>NZ_CP025931.1|WP_013816413.1|486258_486543_-|NifU-family-protein
MTEEIVELVLREQISPLLRSHGGDLSLSQIKDKTVFVRFSGACRFCPAAHETVEKIVQAMIREYFKDDNIDVILENSVSDDLLEQAKNILRKPK

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Crispr_ID: NZ_CP025931_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_4

1372016-1372124

Orphan

Consensus_repeat	Method
GCCCCGACTCAGCTCAAATCGCTGCCATGAAAGCAATGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025931_4

>merge|NZ_CP025931|4|1372016-1372124|CRISPRCasFinder
GCCCCGACTCAGCTCAAATCGCTGCCATGAAAGCAATGGCGGCAAAGATGAAAGCAAATGGAGGGAAGAGCCCCGACTCGGCTCAAATCGCTGCCATGAAAGCAATGGC

>NZ_CP025931|4|4|1372016-1372124|CRISPRCasFinder
GCCCCGACTCAGCTCAAATCGCTGCCATGAAAGCAATGGC	GGCAAAGATGAAAGCAAATGGAGGGAAGA
GCCCCGACTCGGCTCAAATCGCTGCCATGAAAGCAATGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_043890159.1\|1359484_1360729_+\|collagenase	unknown	unknown	gnl\|CDD\|223896
NZ_CP025931.1\|WP_077492526.1\|1363007_1363154_+\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_004585361.1\|1362197_1362773_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP025931.1\|WP_102947763.1\|1376127_1376313_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_004585363.1\|1360784_1361204_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|238329
NZ_CP025931.1\|WP_004585349.1\|1375286_1375613_+\|DUF2149-domain-containing-protein	unknown	unknown	gnl\|CDD\|378306
NZ_CP025931.1\|WP_004584095.1\|1379601_1380192_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl\|CDD\|376414
NZ_CP025931.1\|WP_004585355.1\|1366912_1367563_+\|heme-binding-protein-HmuY	unknown	unknown	gnl\|CDD\|379448
NZ_CP025931.1\|WP_013815625.1\|1377676_1378741_-\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|187557
NZ_CP025931.1\|WP_013815629.1\|1374702_1375281_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223881
NZ_CP025931.1\|WP_013815630.1\|1373960_1374647_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_005874580.1\|1378747_1379605_-\|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl\|CDD\|367904
NZ_CP025931.1\|WP_004584094.1\|1380206_1381076_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NZ_CP025931.1\|WP_012457596.1\|1367577_1369518_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP025931.1\|WP_004585365.1\|1359028_1359472_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|376515
NZ_CP025931.1\|WP_005874565.1\|1376513_1377602_-\|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl\|CDD\|234742
NZ_CP025931.1\|WP_080580280.1\|1363588_1366063_+\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|366737
NZ_CP025931.1\|WP_013815635.1\|1361288_1362059_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_CP025931.1\|WP_013815624.1\|1381190_1383146_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293739
NZ_CP025931.1\|WP_013815637.1\|1357973_1359026_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_043890159.1\|1359484_1360729_+\|collagenase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	2.12222e-87
NZ_CP025931.1\|WP_077492526.1\|1363007_1363154_+\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	5.91792e-06
NZ_CP025931.1\|WP_004585361.1\|1362197_1362773_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	2.89256e-85
NZ_CP025931.1\|WP_004585363.1\|1360784_1361204_+\|acyl-CoA-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	5.19564e-26
NZ_CP025931.1\|WP_004585349.1\|1375286_1375613_+\|DUF2149-domain-containing-protein	gnl\|CDD\|378306	pfam09919, DUF2149, Uncharacterized conserved protein (DUF2149). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.052e-40
NZ_CP025931.1\|WP_004584095.1\|1379601_1380192_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl\|CDD\|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	1.23435e-101
NZ_CP025931.1\|WP_004585355.1\|1366912_1367563_+\|heme-binding-protein-HmuY	gnl\|CDD\|379448	pfam14064, HmuY, HmuY protein. HmuY is a novel heme-binding protein that recruits heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 278 amino acids in length.	5.79537e-30
NZ_CP025931.1\|WP_013815625.1\|1377676_1378741_-\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP025931.1\|WP_013815629.1\|1374702_1375281_+\|hypothetical-protein	gnl\|CDD\|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	2.58967e-11
NZ_CP025931.1\|WP_005874580.1\|1378747_1379605_-\|dTDP-4-dehydrorhamnose-reductase	gnl\|CDD\|367904	pfam04321, RmlD_sub_bind, RmlD substrate binding domain. L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.	1.64758e-126
NZ_CP025931.1\|WP_004584094.1\|1380206_1381076_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	2.00296e-179
NZ_CP025931.1\|WP_012457596.1\|1367577_1369518_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.36309e-97
NZ_CP025931.1\|WP_004585365.1\|1359028_1359472_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|376515	pfam01288, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK).	2.45438e-50
NZ_CP025931.1\|WP_005874565.1\|1376513_1377602_-\|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl\|CDD\|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NZ_CP025931.1\|WP_080580280.1\|1363588_1366063_+\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|366737	pfam01640, Peptidase_C10, Peptidase C10 family. This family represents just the active peptide part of these proteins. Residues 1-120 are not part of the model as they form the pro-peptide, which before cleavage blocks the active site from the substrate. The catalytic residues of histidine and cysteine are brought close together at the active site by the folding of the active peptide.	7.81213e-69
NZ_CP025931.1\|WP_013815635.1\|1361288_1362059_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	2.13399e-84
NZ_CP025931.1\|WP_013815624.1\|1381190_1383146_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	8.79233e-65
NZ_CP025931.1\|WP_013815637.1\|1357973_1359026_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0

>NZ_CP025931.1|WP_012457596.1|1367577_1369518_+|TonB-dependent-receptor
MKSVVTKQALIGLLFFSISIYSHAANPPAQPTDTIVSGNIALEDIVVTGSRTARLLKDVPVPTKVFKAKDIKAIAPSSFIDVLQYILPGIEFTKHGSRDQLNAQGFDESSILFLVDGELISTGSTSGIDFERINPDDIERIEVLRGASSALYGSNAIGGVINIITRTAKDPFRVSASARYDSRDGQKYDVAAGVKRGIFTSQSGVQYRADKSYILADQFEQELNVAGNTTWNINQKFTISPTENLSFNLTGLVNLRKQHWTDKIDFLYNSYDVKAGANWRISETSDLDISYHYDKYSRDTCLIKTENQKKLPIFDEDMHHLRAQYNLNLAEVHLLNVGLEYIHDNVASPRLSSPNDPGEKSVNNKILYGQYIYKVTPKLVLSYGGRLDKHSGFGLYYTSRLSAMYKCSHVTNRLSYAEGYRAPSLQEMYFFFNHGAFFIYGNPDLKPEKSRMLSYSAEAHWNKLTLMGNVFFNHVRNRIDFTYKGTDLIYTNVSKEMRIFGFEGQANVVLPYGFGFRASYSYTYDRWKATDKAGTEMKLSNTRPHAATATLSYGHNFSKNYRLASNFSTRFLSDLKTGRMNSNELFEEITYPGYTICRLDIENHFYRNYTLHIGAENLFDYKPKALAFNSPTSPGRIIYGLVRITF
>NZ_CP025931.1|WP_004585355.1|1366912_1367563_+|heme-binding-protein-HmuY
MKKIIFSALCALPLIVSLTSCGKKKDEPNQPSTPEAVTKTVTIDASKYETWQYFSFSKGEVVNVTDYKNDLNWDMALHRYDVRLNCGESGKGKGGAVFSGKTEMDQATTVPTDGYTVDVLGRITVKYEMGPDGHQMEYEEQGFSEVITGKKNAQGFASGGWLEFSHGPAGPTYKLSKRVFFVRGADGNIAKVQFTDYQDAELKKGVITFTYTYPVK
>NZ_CP025931.1|WP_080580280.1|1363588_1366063_+|T9SS-type-A-sorting-domain-containing-protein
MLQAGPVTRSKAEQTAKNFFAKRQPTLSSSTASLRMDFVYKTTEREEALFFVFNRGEKDGFLLVAADDRFPEVIGYAFKGHFDAARIPDNLRGWLKGYEREMLAVMDGKAEPIDPIREAKPTRDLPSSIAPILETGEHASDPILWDQDYPFNTLHPLLPSGQQAYTGCVATAMGQIMRHYKWPEKASGGYDYYDDMTGTHTHYSGTFGETYNWSKMPGNISVGISPEEVKALSTFMRDVSFSVNMQFADFGSGTFSIFVERALRETFHYKKSLRYIHRSLLPGKEWKDMIRKELAENRPVYYAGADGSMGHAFVCDGYEPDGTFHFNWGWGGMSNGNFYLNLLNPGSLGTGAGDGGYSTDQEVVIGIEPASNEAPGIVPDPTITLYGLQHNMSDEALDLSVKIKNYSTYAGDVKLAYRLTLPNGTETTNPAVTVPIVWEDIIGESTGNITIPCSQFAEGKNTISILYRTDGMADWKELKHILMGLVNKIEVTMPAGDVAYSVADARIVLKDGSLSHNLKAYSDCKLSATVYNPGTEEFRSRVTFALRNTEGRLYFLGRHLVELHPGDEDGEKVSLTITGLKARAGQYMLVCTGDMESLMEDASWIELASIEVAEHTSTHSSLLVASNPQIDLLTVHRANPETLPTFSITNEGGATFSGKIEIVAIKAFSETFFQAKEEHMSLAQGETKVLSPELTASSSLYTNAELFPDGIYYIVIREQGFWDPIDLFGDYYYRIRLITDLSSSDIAGKDVSTIVLYPNPAHDYVHVAIPPTYAGSTLRLFDIQGRMQLSTKIESADMRLDVERLPKGTYIVVVEDMVGKLFIR
>NZ_CP025931.1|WP_077492526.1|1363007_1363154_+|DUF1661-domain-containing-protein
MLLLKTRFVNFFILAWEAKNSHATTKKISRHFFREYAPQSELFRFVFF
>NZ_CP025931.1|WP_004585361.1|1362197_1362773_+|superoxide-dismutase
MTHELISLPYAVDALAPVISKETVEFHHGKHLKTYVDNLNKLIIGTEFENADLNTIVQKSEGGIFNNAGQTLNHNLYFTQFRPGKGGAPKGKLGEAIDKQFGSFEKFKEEFNTAGTTLFGSGWVWLASDANGKLSIEKEPNAGNPVRKGLNPLLGFDVWEHAYYLTYQNRRADHLKDLWSIVDWDIVESRY
>NZ_CP025931.1|WP_013815635.1|1361288_1362059_+|peroxide-stress-protein-YaaA
MLILLSCTKTIGIPKRLPSHLTTTSPIFDEQTTKIALAASSCDIEELSRLLRINRKLAEENHRRWQHFFEDDSPTAPAALAYTGMVFKKLAPANFNADDWLYASEHLLITSFLYGLLRPSDMIRPYRMEGFAHLGAPVEDEVFNFWRPYLTDFLIEKVREKGGELCFLASEEMKMLFDWKRVEQAVRVVTPLFKVPQPDGGLKQIVIYTKMARGLMTAHLLTRRCRHVEEMQLFSPEGFIFRPELSDESNYLFVME
>NZ_CP025931.1|WP_004585363.1|1360784_1361204_+|acyl-CoA-thioesterase
MKEKEYLFSLDMKVRDYECDLQGVVNNSNYQRYMEHTRHEFWESLGDNFGQMHEKGLDAFVYKVTITFKQSLRSGDRFRSCLTCHKKGPKLIFMQDIIREDGVMAACGEVEVVAVQDGVLTRGEYFDVLMKDILSKTTK
>NZ_CP025931.1|WP_043890159.1|1359484_1360729_+|collagenase
MNVNDFEIMAPVGSYESLMAAIKAGADSVYFGIEGLNMRARSANNFTTEDLYKIAEICRNKGVKSYLTVNTVIYDEDIALMRSVIDAAQKAQISAIIASDVAAMTYANEIGVEVHLSTQLNISNAEALRFYSRFADVVVLARELNMDQVRTIHETIVRDNICGPKGHPVRIEMFAHGALCMAVSGKCYLSLHEHNSSANRGACAQICRRGYTVKDKDSGLELDIENQYIMSPKDLKTIHFINKMMDAGVRVFKIEGRARGPEYVYTVCRCYKEAIEAYCNGTYDEESIGRWDEQLATVFNRGFWDGYYLGQRLGEWTHRYGSGATRQKIYVGKGIKYFSRLGVAEFEIESGELHIGDEIVITGPTTGVIIQKVEEIRYELQTVEKATKGQRISIPVKEKVRPSDKLYRFDKREE
>NZ_CP025931.1|WP_004585365.1|1359028_1359472_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MAIVYLSLGSNLGDRHSLLSAALEMLQTRVGRLLTLSRFYETEPWGFESPHPFLNAVVALRSELKPQDILHITQAIERELGRTQKSNGGVYHDRPIDIDILLHSVYPKVQSPELELPHPQMWQRDFVRMPLSDVAPWLHPEAPTPNL
>NZ_CP025931.1|WP_013815637.1|1357973_1359026_+|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MKLSKFKFNLPEELIALEPTKFRDESRMMVVHRRTGEIEHRVFKDILEYFDKGDTFVFNNTRVFPARLYGNKEKTGAQIEVFLLRELNERLKLWDVLVDPARKIRIGNKLYFGNDEELVAEVIDNTTSRGRTLRFLYDGSHDEFKELLFQLGQTPLPKYIDRDVNKEDPERYQSIFAEVEGAVVAPAASLHFSRELMKRLEIKDCHFSYITVHHALGAYRDIDVEDLTKHKMDSEEMYITEESCININRSWDEEKKICAVGTSILRALETAVSTDGHLKPFEGWTNRFIFPPYEFHLPSALVTNFHMPLSTLLMMTAAFGGHEPIMSAYDLAVKEKYRFGAYGDAMLIID
>NZ_CP025931.1|WP_013815630.1|1373960_1374647_+|hypothetical-protein
MREVLLTIALLATLKYLFEEGVHSSLLVRCLHAAVYAAFIALVHGLTQHVSRMEVETLLYSPEALRNVSLAVMVDLLYVVYICTHRPSSFRLYRTWVRHLPPLLFFPTLFYLRLSLFYVLPGYSFVGVSIVMALIVAALSITAPYLWRALGLKREALREPLVLLSLCTFVFVIAAGVLHPDSAVRTVGITTDWWQALYLFLIVLAGASIGYFAPRLWAIIRRKNNRKK
>NZ_CP025931.1|WP_013815629.1|1374702_1375281_+|hypothetical-protein
MNFLSNVMFWVSNGLLVPVVAGLIYLFIKSLLLLGTLFGTWQSYRRRQETFARIIENKAGLDTEALRAEAAKRPHAPFENVLAEVLDADSARRNLLIGRYELSREQRLSSAKVLTKFGPILGLMGTLIPMGPALVGLSTGDIGQMAYNMQVAFATTVIGMFASAVGYIALHIVRTYNRNDLVWLDYINEKLS
>NZ_CP025931.1|WP_004585349.1|1375286_1375613_+|DUF2149-domain-containing-protein
MSRRRFHEEDTDPSSLVSNLFDVAMVFAVALMVALVTKFNMTEVFSKEDYTIVKNPGKDNMEILIKKGDKVEKYTPSDESSDGAGSKGKRVGVAYQLESGEIIYVPED
>NZ_CP025931.1|WP_102947763.1|1376127_1376313_+|hypothetical-protein
MVSYERILWFIDGRCYLLCVGWQVREVGGSVRAVRPIDAYRNSLSTRGQSNLFPFLFLIWL
>NZ_CP025931.1|WP_005874565.1|1376513_1377602_-|glycine-cleavage-system-aminomethyltransferase-GcvT
MKTTPFTDVHIALGAKMHEFAGYNMPIEYGGIIDEHMNVVNNVGVFDVSHMGEFWVKGPNALRFLQKVSSNDASKLAVGQVQYCCFPNNDGGIVDDFLLYRYEEEKYMMVPNAANIAKDWAWCRQQNTMGAILENASDNIAQLAVQGPKATEVMQRLTDIDLNEITYYTFKVGSFAGCPDVIISATGYTGAGGFELYFYPQYAQKIWDALFEAGKPEGIKPAGLGARDTLRLEMGFCLYGNDICDTTSPIEAGLGWITKFTDDKMDMPSRKIMEEQKAGGLKRKLVAFELKDKGIPRQHYEIANAEGQIIGEVTSGTMSPCLKKGIGMGYVATEFSKVGTELGIMVRGRQLKAEIVKPPFRK
>NZ_CP025931.1|WP_013815625.1|1377676_1378741_-|dTDP-glucose-4,6-dehydratase
MNFRRHILITGGAGFIGSHVVRLMVNGYPDYEIINLDTLTYAGNLANLKDIESKPNYRFVKADICNANTLKKVFAHYAIDGVIHLAAESHVDRSIKDPLAFARTNVMGTLTLLQTAKEAWHGEYEGKRFYHISTDEVYGALAFDGTLFTEETKYDPHSPYSASKASSDHFVRAYHDTFGLPTVISNCSNNYGPYQFPEKLIPLFINNIRHNKPLPVYGKGENVRDWLYVEDHARAIDLIFHRGKNGDTYNIGGFNEWKNIDLIKVMIRVVDRLLGREEGSSEKLITYVADRAGHDLRYAIDSTKLKNELGWEPSLQFEEGIEKTVRWYLHNQDWLDRVTSGDYLRYYDEMYSER
>NZ_CP025931.1|WP_005874580.1|1378747_1379605_-|dTDP-4-dehydrorhamnose-reductase
MNRILVTGADGQLGSELRLLASADSRFVFTDLAELDIRDKDAVLRFMEEYSIGIIINCAAYTAVDKAEDDEASAEKVNHQAAAHLAAAAAKYDALLIHISTDYVFDGTANIPYREDIPTAPLGAYGRTKLKGEQAVLAADCRYMILRTSWLYSSFGNNFVKTMLRLTAERDTLNVVFDQVGTPTYAADLAAFIHRLAIGQLPVKTGLYHFSNEGVCSWFDFAVAIARMSGHTACRISPCHSDEYPTRVRRPHYSVLDKTLIKNTFDISIPHWQDSLAACLNLLKH
>NZ_CP025931.1|WP_004584095.1|1379601_1380192_-|dTDP-4-dehydrorhamnose-3,5-epimerase
MNFIPTEIPEVVILEPRLFRDDRGYFFESFSRQEIETGIRPINFVQDNESASRYGVLRGLHFQKPPHAQSKLVRVVRGCVIDYAVDIRFGSPTFGKYVAVELSDTNFRQLFIPRGFAHGFVVLSDEVVFQYKCDNYYAPQSEGAIAWNDSNLDIDWKIPAEDIILSAKDQANPSWTELISSEDFRNLFPYNQDLYE
>NZ_CP025931.1|WP_004584094.1|1380206_1381076_-|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSTLMLAGIRDVLIISTPQDLSMFQRLLGDGRDLGVRLEYAEQPSPDGLAQAFIIGREFVGDDCACLVLGDNIFYGHGFSQMLRSAVADAEKGMATIFGYYVNDPERYGVAEVDATGKVISLEEKPEKPKSNYAVVGLYFYPNDVLDVAADVKPSARGELEITSVNQEFMLRKQLRLQQLGRGFAWLDTGTHESLTDASVFVSVIEKRQGLKIACLEEIAYNNGWLTKEDLARVAEPMKQNQYGKYLLGLIK
>NZ_CP025931.1|WP_013815624.1|1381190_1383146_-|alkaline-phosphatase-family-protein
MNICKRTIRTNSWWAFAYRMALAYFFFGIARGLFYLFNYRFFADMTAEQVWRAWMGGLRFDTASVLYLNALFILLSFLPFRFRTKRSYRILTDWTFFVPNALGLAAGLADCIYYPYTLKRTSSTVFSEFSHEGGGLIWHLLLNYWYMSLLAIVLVAAMVWLYHRVKPVRTYAEAKDSLHYYTVHVVALVAAIAFIVWGIRGGSFAKSWRPMTMSYANLSVDKVEHRALVLNTPYSIIRTIGKQGLEEKRFYASEKELEQVFNPIHHLATDTTARFSQLRGRNVMVIIIESFARQYVGRLNQDIPDYKGYTPCFDSISQKGYLFEQAFANGRKSIDAMPSILSSLPSLRSHFITSHYSGNEIEGLGTALGRIGYQSIFLHGAPNGSMGFDAFVKQAGYKRYFGKTEYANDEDFDGVWGIWDEPFLLHAVDELSRMKQPFVGTLFTLSSHEPFHIPSHREGLFPNEGEPLVQCIGYTDHALGEFFRKASRQTWFENTLFVITADHASGDLRPEYRSAVGRYAIPILFYAPGSDLIGFDRTTTVQQADILPTVLSLLGYSAPVLAFGNNMFSRQAPHFAVTDYDGTLQLLEDGLVLQHDGNHPLALYDYLNDKELRTNLIKTQTARADSMTCRIEAVIQSFNHRMNTNRLVADK

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Crispr_ID: NZ_CP025931_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_5

2110817-2110914

Orphan

Consensus_repeat	Method
CTTCGAATCCGTTTATATAAGGCCTAAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP025931_5

>merge|NZ_CP025931|5|2110817-2110914|CRISPRCasFinder
CTTCGAATCCGTTTATATAAGGCCTAAAATATTACTACGGGAAAGCCCAGCGAACGCATTGCCGGAATCTTCGAATCCGTTTATATAAGGCCTAAAAT

>NZ_CP025931|5|5|2110817-2110914|CRISPRCasFinder
CTTCGAATCCGTTTATATAAGGCCTAAAAT	ATTACTACGGGAAAGCCCAGCGAACGCATTGCCGGAAT
CTTCGAATCCGTTTATATAAGGCCTAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_004583610.1\|2102732_2103737_-\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|223117
NZ_CP025931.1\|WP_004583625.1\|2113594_2115862_-\|phosphate-transporter-family-protein	unknown	unknown	gnl\|CDD\|376541
NZ_CP025931.1\|WP_004583622.1\|2112756_2112906_-\|DUF4295-domain-containing-protein	unknown	unknown	gnl\|CDD\|379486
NZ_CP025931.1\|WP_157761733.1\|2103868_2103961_-\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_013815252.1\|2117665_2119072_+\|sugar-transferase	unknown	unknown	gnl\|CDD\|274398
NZ_CP025931.1\|WP_013815245.1\|2105740_2107441_+\|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	unknown	unknown	gnl\|CDD\|235424
NZ_CP025931.1\|WP_004583632.1\|2119068_2120865_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NZ_CP025931.1\|WP_013815251.1\|2117093_2117669_+\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|376519
NZ_CP025931.1\|WP_013815253.1\|2120825_2121890_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|182386
NZ_CP025931.1\|WP_013815246.1\|2108176_2109112_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP025931.1\|WP_013815249.1\|2116058_2116682_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|273496
NZ_CP025931.1\|WP_004583612.1\|2104198_2105359_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP025931.1\|WP_013815248.1\|2110923_2112219_-\|acetyl-CoA-hydrolase/transferase-family-protein	unknown	unknown	gnl\|CDD\|223504
NZ_CP025931.1\|WP_004583624.1\|2113132_2113372_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP025931.1\|WP_010956453.1\|2107468_2108116_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP025931.1\|WP_013815247.1\|2109115_2110135_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NZ_CP025931.1\|WP_004583623.1\|2112924_2113113_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|177033
NZ_CP025931.1\|WP_013815242.1\|2101038_2102460_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP025931.1\|WP_013815241.1\|2097531_2101014_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|369506
NZ_CP025931.1\|WP_102947768.1\|2103929_2104052_+\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_004583610.1\|2102732_2103737_-\|malate-dehydrogenase	gnl\|CDD\|223117	COG0039, Mdh, Malate/lactate dehydrogenases [Energy production and conversion].	2.08354e-62
NZ_CP025931.1\|WP_004583625.1\|2113594_2115862_-\|phosphate-transporter-family-protein	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	3.15944e-08
NZ_CP025931.1\|WP_004583622.1\|2112756_2112906_-\|DUF4295-domain-containing-protein	gnl\|CDD\|379486	pfam14128, DUF4295, Domain of unknown function (DUF4295). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (K and Y) that may be functionally important.	4.93541e-19
NZ_CP025931.1\|WP_157761733.1\|2103868_2103961_-\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.00360915
NZ_CP025931.1\|WP_013815252.1\|2117665_2119072_+\|sugar-transferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.55214e-129
NZ_CP025931.1\|WP_013815245.1\|2105740_2107441_+\|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	gnl\|CDD\|235424	PRK05347, PRK05347, glutaminyl-tRNA synthetase; Provisional.	0
NZ_CP025931.1\|WP_004583632.1\|2119068_2120865_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	9.43748e-102
NZ_CP025931.1\|WP_013815251.1\|2117093_2117669_+\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|376519	pfam01300, Sua5_yciO_yrdC, Telomere recombination. This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.	4.65026e-52
NZ_CP025931.1\|WP_013815253.1\|2120825_2121890_-\|mechanosensitive-ion-channel	gnl\|CDD\|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	1.49128e-59
NZ_CP025931.1\|WP_013815246.1\|2108176_2109112_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	5.11744e-47
NZ_CP025931.1\|WP_013815249.1\|2116058_2116682_-\|DNA-binding-protein	gnl\|CDD\|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	7.03433e-42
NZ_CP025931.1\|WP_004583612.1\|2104198_2105359_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	6.19746e-42
NZ_CP025931.1\|WP_013815248.1\|2110923_2112219_-\|acetyl-CoA-hydrolase/transferase-family-protein	gnl\|CDD\|223504	COG0427, ACH1, Acetyl-CoA hydrolase [Energy production and conversion].	1.62269e-113
NZ_CP025931.1\|WP_004583624.1\|2113132_2113372_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	6.96682e-31
NZ_CP025931.1\|WP_010956453.1\|2107468_2108116_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.05569e-31
NZ_CP025931.1\|WP_013815247.1\|2109115_2110135_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	2.0029e-43
NZ_CP025931.1\|WP_004583623.1\|2112924_2113113_-\|50S-ribosomal-protein-L33	gnl\|CDD\|177033	CHL00104, rpl33, ribosomal protein L33.	1.21956e-18
NZ_CP025931.1\|WP_013815242.1\|2101038_2102460_+\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	3.18902e-12
NZ_CP025931.1\|WP_013815241.1\|2097531_2101014_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|369506	pfam07767, Nop53, Nop53 (60S ribosomal biogenesis). This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumor suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.	2.02883e-08
NZ_CP025931.1\|WP_102947768.1\|2103929_2104052_+\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	4.74182e-05

>NZ_CP025931.1|WP_013815247.1|2109115_2110135_+|NAD(P)-dependent-oxidoreductase
MGNKRVLITGATGFIGGYLVDEALRRQYEVWAAVRPHSDRSRLTDSRIRFVEIDYRDPSDIARLADKIAPEGESAWHLVIHNAGITKARDTSLFREINAEQTKRFLIGLQGAKHCPERFVLMSSMGSYGAPPDDCQPLSSSSVPKPTTAYGESKLLAEQYVQTFVTIPYTIIQPTGVYGPHDQDYLMAIRSVDKGFDFSTGNTPQTLTFIYAEDLASAVFIAAEHPDAAGQKYIVSDGKEYTDIEFGRMIQHLLGRKNVCHLRIPLPLVKATCYIGQKWADISGTLTPLNLDKYAIIAQRNWRCDSSPIRAIGFSPRYNLEQGLAETIRWARTTGQIRR
>NZ_CP025931.1|WP_013815246.1|2108176_2109112_+|YitT-family-protein
MALTKTSKLYYKVHDYILIILGCSIYAFAWTGLILSQGITTGGLAGISTLIKIATGIPAAIPYNIINLGLAVLALIFLGWRFMVKTVISVVIMAIIIPIGEEYLVVTEIVNGVKVFTPLLLPNEPALALVIGSILSGLGIAIVFSVNSSTGGTDIIVAIMNKYKNMSFGRAILLVDCTIILCSYLVNVYIAGKSPSDAFNLLIYSAIEVILVSTVLDWYLNSNRQSVQFLIFSLKNEELSNAIQERIKRGCTLLDATGGYSGQPCKVLVVVARKTQSLSIHRIIQEIDPKAFVSESVVRGVYGEGFQAIRK
>NZ_CP025931.1|WP_010956453.1|2107468_2108116_+|DedA-family-protein
MGFIQWCLAHLNYWTIMFLMAIESSFIPFPSEIIVPPAAWMAATGQNGLNVFLVILFATIGAGIGAAVNYILSLLLGRPIVYAFANSKLGHLCLINEEKVRYAERYFDKNGAVSTLVGRLIPAVRQLISIPAGLARMKFLPFISYTMLGAGIWNCILAAIGYNLAKVPGIETQEQLLEKVNKYSHEIGFSIMGVVVVVLLIMFYKKKRRSARKGN
>NZ_CP025931.1|WP_013815245.1|2105740_2107441_+|glutamine--tRNA-ligase/YqeY-domain-fusion-protein
MNENKNSGIEEKKSLNFIEQIVESDLSEGKNDGRIQTRFPPEPNGYLHIGHAKAICIDFGIAQRYGGVCNLRFDDTNPVKEDVEYVDAIREDIEWLGFHWGNIYYASDYFQELYDFAERLIREGHAYVDEQTAEQIAAQKGSPTVPGTASPFRDRPAEESLDLFRRMNAGEFEEGAMTLRAKIDMASSNMHFRDPIIYRIIKHPHHRTGNEWNVYPMYDFAHGQSDYFEGVTHSICTLEFEVHRPLYNYFIELLRKDSYAPRQIEFNRLNLTYTMMSKRKLLQLVKDGLVSGWDDPRMPTLCGYRRRGYTPESIRNFIDKIGYTKYDGIIDVALLEHAVREDLNKRATRVSGVIDPIKLVITNYPEDKTEEMAAVNNPEDESAGVHTITFARELYIEKEDFMEDAPKKYFRMTPGQEVRLKSSYIVRCTGCKKDEDGSVVEVYAEYDPLTLSGMPESNRKVKGTIHWVSARHSLPAEVRLYDRLFTDENPSDIKDKTLAEMLNPDSLKVLKSCRVEPFLADAAPGSHFQFQRIGYFTVDPDSRPGALVFNRTVSLKDSWQKAQKNA
>NZ_CP025931.1|WP_004583612.1|2104198_2105359_+|AI-2E-family-transporter
MQSFFDREFTFDRTARLFFIILLVGGIMAIVIGLRGILIPFCLSWILAYVLMPLVRFVQYRLHFRFRFLSVITVLVFISALIFFAILSLVPAVEEEVSKTITLLQQYRIDENLLQMLPAPIRKFLSESGSMNDLFKGISYEKLMENSKEIFGQLNKLVSGTISLFSYTTIFFIGVLYFIFILFDFEKLGKGFVNLFPVGHRIRVRSILKEVDKNMNSYFRGQALIALCVGILLSIGYKIIDFPLGVTLGLFIGMLNLIPYLQIVGLIPIVFLSVLKAAQTGQNFFVVLALGIGVMMIVQVIQDTILTPNIMGKRMGMSPAMILLSISIWGSLLGFFGLFIALPLTMSLYSVYKRYVIQDPKFIREENEETMPRKGLFRKHSRKEEK
>NZ_CP025931.1|WP_102947768.1|2103929_2104052_+|DUF1661-domain-containing-protein
MVREAKNSRATTKIFSRLFFRILRPQSEHFPFVFSRKQIS
>NZ_CP025931.1|WP_157761733.1|2103868_2103961_-|DUF1661-domain-containing-protein
MAREFFASRTKTKIFSSHVLRTVEWLIFGA
>NZ_CP025931.1|WP_004583610.1|2102732_2103737_-|malate-dehydrogenase
MSYLTEEKLTIVGAAGMIGSNMAQTAAMMRLTPNLCLYDPFAVGLEGVAEEIRHCGFEGLNLTFTSDIKEALTDAKYIVSSGGAPRKEGMTREDLLKGNAEIAAQLGKDIKSYCPDCKHVIIIFNPADITGLVTLIYSGLKPSQVTTLAGLDSTRLQSELAKHFGIKQSLVTNTRTYGGHGEQMAVFASTAKVNGTPLTDLIGTDKLTNEQWAELKQRVVKGGANIIKLRGRSSFQSPSYVSIEMIRAAMGGEAFRWPAGCYVNVPGFEHIMMAMETTITKDGVKHSDINQLGNEAERAALKESYSHLAKLRDEVIAMGIIPAIADWKTVNPNL
>NZ_CP025931.1|WP_013815242.1|2101038_2102460_+|alpha/beta-hydrolase
MKHKIIIIIYVVVLLMTTMSCKSQKFAGDWSGRIPRGNGSLALVVHLKQTGNTWQGSMDSPDQQAFGIPLSSVTVVGDSLSIAVQDLLLSYKGKLKNDSIEGEFRQGRFGTMMSLYRGLDAAKPYRPQTPVPPFPYDVTDVKILHKTGGFTIAGTLTAPKDANKTKGTVILISGSGLQDRDETIFGHKPFAVLADQLTRHGYAVLRCDDRGFGESAGDASQATTDTLAGDIESELAYLRQHYPRLTDKVFLIGHSEGGIIAPMVARRVGGIAGLVLVGAPSVKGAEILLSQNAAMDEFATGQPQSQAKRAALEELIRQATAPGDSSDIRTRIESYCRSNASVLFPQAMTDEMKEQGIKLMTEQLSNPWMRHFLTYDPAPLLDVTSGEGSHPLPPTMAIYGGRDKQVLHEVNMSKMKSLLGIETGNTANKVVYLPEVNHIMQPAEFGTPDEYAFLNRTVDTELMEIVCSFLDSL
>NZ_CP025931.1|WP_013815241.1|2097531_2101014_+|tetratricopeptide-repeat-protein
MRSHRFLYLLVFYLLIPVAVVFGMLSCSTSKNTAASRFYHNFTTRYNVFYNGQNAYNDAYDRLLESHTEGYSEEIFLDPITAQSGQEKAKEGGAFDQAIVKGRKAIHLHSIRTKPERKQGWQSDPKAVAFQNKREYNRFLHNAWMLVGKSQFYNADFLQAQATFSYIARLYSNEPIIRDEARLWQVRCYSEMGWLHEGERLLERIPKDLPHVDRRGLYSLAVAERSILSGDKRAAIPYLQQAARQEKNKRQRARMYYLLGQLLQENNRPEEARKAYSKVLRASPPFALDFAARIRKMELEGERNPRTVAARLERMAKKGKYKEVLDQIFYAAGNIYMDIPDTLAATKAYTTGIEKSTARGADFALCQIRLGDIYMQRKQYLKAQPCFSAAAGVLNRLNPDYKRVAELSSQLDELVGHAKVVHEQDSLLALAAMPEEQRLAIIDSVINAYAIAEKKRLEEEEMAKLQQSQELFNAESEGFAPSPGGKTQNPPPGMQTGGASGEFYFYNPQLIAQGKAAFERKWGKRVLEDDWRRRRKQANFDIPTDDSSTTEETDETQPGTLMTEEELQAAAADSAASNPLNREYYLAQLPMTEDAKEAAGKLIAEGLLGMGAVFNERMEKFDESADTYETLLRRYPNYEKKMDVLYRLFMLYTRMNNKQEAERCRALILQYYPEDNLAKALSNPDYLKELAAMDRRQNELYEQAFDSYLKGVVGSVRKSRNECRERFPLSELAPKFDFLNALCYVLESDSKGFTSALKQLVKDYPKADVTELASSMLTELLRGRSIVQGGYTGIDWDIRWGGSDTDSISPDSLPPFVKPKSFERTRLILLAPAGTLNKNRVLFALASFNFSRYTEQTLEIVQSTVGAFDQWLMTSLPTPRMGWQYIKDAFAPNGFMSAMSESSLLFPISESNYQLLVKGKSIGQYMTFLAKEEVPETAFVLDRWQQMTGRAQAVGKEDEDIEPAGTPAPIVSDKNEAEDTARDSTSGTDRKPLVSIKPHKDSIMTATPITFDIDREQILSGAKPVAADSSAADTISDAAALPSLKQQEGKDVSVEQIQRLAKERAQNEKDEKKALEKAKREKERDRKRELKAREKEREKARRDKLKDQRLKQKEREQKLKEKERERKEKLRQRERERKARAKEREQKKKAGQNKSGGGPQ
>NZ_CP025931.1|WP_013815248.1|2110923_2112219_-|acetyl-CoA-hydrolase/transferase-family-protein
MQWQELYRQRVCSADEAVVDSLKPGTKVVFGHAAAAPVRFSQAMYRQRERLENITVFHMLYFGDAPHLAPEMRSHVHPTLNFLEGNSRPASRDRRVDFIPCHFHEVPELFRQGFFPLDVAVVQVSTPNEEGYCSFGVSCDYTKAAAECAPVVVAEVNKQMPFIGGENLIHISKLTHIIEVDEPIAEVLPPAISDLELRIGQNCASLIKDGDTLQLGIGGIPDAVLRALEGHKDLGIHTEMFTDGVMRMIRKGIINGKKKTLHPEKVVTSLIFGSKELYDFVNNNPVIECYPVDYINNPDVIGKNDRMVSINSCLEMDLMGQAASESIGYEQFSGSGGQVDFLRGAKRSKGGISIMAFPSTAKKGAESRIVPILKEGACVTTGRNEVDYVVTEYGVARLRGATLRQRAEALTAIAHPDFRPALEEEIRRRFE
>NZ_CP025931.1|WP_004583622.1|2112756_2112906_-|DUF4295-domain-containing-protein
MAKKSVATFKKGDGRTYSKVIKMVKSPKTGAYTFQEEMVPNEAVKDFFK
>NZ_CP025931.1|WP_004583623.1|2112924_2113113_-|50S-ribosomal-protein-L33
MAKKVKGNRVQVILECTEHKESGMPGISRYITTKNRKNTTQRLELKKYNPILRRMTLHKEIK
>NZ_CP025931.1|WP_004583624.1|2113132_2113372_-|50S-ribosomal-protein-L28
MSKICQITGKKAMVGNNVSHSKRRTKRVFDVNLFRKKFYWVEQDCWVVLRISAAGLRLINKIGLDAAIKRAAEKGFLNA
>NZ_CP025931.1|WP_004583625.1|2113594_2115862_-|phosphate-transporter-family-protein
MSLIFTAIVVFLFILAIFDLIVGVSNDAVNFLNSAIGAKAAPFKIIVGVAALGVFCGAAMNNGMMEIARHGIFRPEHYTFSELMVVFLSVVITDVVLMDMFNSLGMPTSTTVSLIFELLGGSFFMAMTKVGGTVGFQDLLNTEKALSVILGIFLSVGIAFFFGMVVQYLSRLLFTFNYRRNLRWLAGLFGGVAVTSIIYFMLIKGLKGVSFMTEESTAWIAANTGRLVLYCLVVSIILMQVLYWLRVNVFKVIVLLGTFALAMAFAGNDLVNFIGVPLAGYSSYLDFNANGNGQYGTYLMGALNEPASTPVYFLVAAGIVMVYALITSKKAHNVIKTSVDLARQEEGEEMFGSSGLARSIVRFSTTTANAVSRIIPRPVGRWIDSRFNQDELIMAKGAAFDLVRASVNLVLAGLLIAFGTSLRLPLSTTYVAFMVAMGTSLADRAWSRESAVFRITGVFSVIGGWFITAGAAFILCFLVTMVNHFGGYPAMAGMIILAIFLLVRSHIRFDKKKKSETKDTVFIDMMASHDKEEIWQLLAKHIRQKQLALLDFAENNYMQMTDGFINEDLKRLRRSINDQNAERQMLKVNRRKETLGIRRIEEAKSVVKNTWFHLGCNSCEQIVFCLKRIAEPCKEHVDNNFNPLPKVCVSEFLAAREKLILYIKEAKLIVSNETDEILDPMTYRGKDIKKELKQLRKTQLSRIQQGASSLKISLVYLNLLQESQQLVNILDDLIHATEKLFDPVARIGTDEEFFN
>NZ_CP025931.1|WP_013815249.1|2116058_2116682_-|DNA-binding-protein
MAKFVMREMPDMQGTGKRTMYPKMISRGTMGLDEIADLISSQSTFSPGEVKGLVTALARTIAHGVASGYTVKIEEIGSFSASLTLHKGVEPEEAEGGTRRNAASVTIGGVNFRPDKALILEARTRVHLVRTTVRRPRRPNLTREERLALALRHLDGHSLLKVADYCRLTGLGRTAAAEELRAFDREGLIDSTGSGTHKVYIRNKAGI
>NZ_CP025931.1|WP_013815251.1|2117093_2117669_+|threonylcarbamoyl-AMP-synthase
MLNDIQRSEAKKAAEVMRKGGIILYPTDTIWGIGCDATNEEAVRRIYRLKERADSKSMLVLIDSEAKLQGLMDEVPELAWDLIELTTKPLTIIYPQAKGVAPALIASDGSLGIRLTRETFSAELCRLMRVPIVSTSANISGQPSARTFGEIAPAILDGVDYIVECRREEPAGQASSIIRLGTRGEVEVIRQ
>NZ_CP025931.1|WP_013815252.1|2117665_2119072_+|sugar-transferase
MTRMQLHRLRYLLADVFGIVASYLSYNTLRYLTEEQERIYSTLSEYLFNAKSLWVGILYLLFWLSLFALSGYYNKPIAKSRISELLTTVASVLVGSVVVFLLLVVDDIVHDTALYLRLFFMMVATVLPWVYFPRLWVTTFGIKERKKTKGYHRVLLIGSGTIAEETASWLKSVNDMATTRLHFVPPTTREGFEQSLKSFATLVAEAVQESKPHQIILAVDCPDASFISLLLYQLYPFHMPVCVPMRSMLFAGAKVNVQGMKGEPMVDMTATNMSECAKSIKWFADRLFSLLMLILLIPVYAVIAVLVKRSSRGPVFFGQERIGLHGRPFTIYKFRTMYLDAEKDGPSLSFDGDSRVTPIGRILRKYRMDELPQFWNVLRGDMSFVGPRPERAFYIRQLVERAPYYYLLHNVRPGITSWGMVRYGYASTLDEMLERLQYDFLYYENMSLRLDIEVLLYTCQTIFKGLGK
>NZ_CP025931.1|WP_004583632.1|2119068_2120865_+|chloride-channel-protein
MKDKETSRYGWFLHFLLWRERHINERLFLIILSLIIGILSAFAAVLLKNTIHIIQHFAFDRIRETSYLYLIFPVVGILITWLFVRYVVRDDIGHGVTKILFAISQRKSRIKPHNMWSSLAASSITIGFGGSVGAESPIVLTGAAIGSNLGRLFRMEQKTLMLLVGCGAAGAISGIFKAPITGLVFVIEVLLLDLTMSSVLPLLISSVSAAAVSYIITGQGAMFSFTLNDPFSMDRIPYALLLGVFCGLVSFYFSKVMFVFESKLKNFPHYRQRYLISAFILCGLIFLFPPLYGEGYDTINALLGGQYSSLMDGSLFEPYSNSYWVLFVFLGFIIITKVFASVATNSGGGCGGLFAPSLFMGALSGFIFAYALNFFPFIEVYLPQKNFALLGMAGVMAAVMHAPLTGIFLIAELTGGYNLFLPLMLVSTSSYATIRLFMPHSIYSLRLAQKGKLLTHQKDKAVLTLMTLDAVIEKDFEPVRPDMTLGDVVHVFGISHRNVFPVLDENNLLMGLVLLDNIRNIMFRPELYERFKVSRFMVSPPAKIVNTMSMETIMRIFDDTKAWNLPVIDEQGCYLGFVSKSKIFNSYREVLVETFSGD
>NZ_CP025931.1|WP_013815253.1|2120825_2121890_-|mechanosensitive-ion-channel
MPADSVSAGLSASINDIKVTNRMGLKIFFPLQNLSVDTTKVNKIAEVVSPEALKQIKEIKPSQWTELLTQWGGKALSFGIKVLIALVAFYLGKLLLNALVKWLDRIMVRRSFEPAARTFLRSFANIGGFVLLIVIIISTLGFQPVSLAALLASVGVAVGMGLSGQLQNLAGGLIVLLTKPFKVGDYIVSNNVEGVVDGVTLFHTTVMTFENKYIFIPNGLLSSNVIINYSRMAVRRNEWIIGIEYNEDFDRVKTLLLRLIDEEPRIIKDPLPTVVLKELADSSVRVMARAWCATDDLWNVYWDINERIYSEFNRQGIAFPFPQLTIHGSAAGQERRGKSTEAQSPENVSTNTSL

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Crispr_ID: NZ_CP025931_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_6

2124543-2124651

TypeIII

Consensus_repeat	Method
AGGAAGCCGTTGTCACGTGACAATCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cmr6gr7

The CRISPR arrays of NZ_CP025931_6

>merge|NZ_CP025931|6|2124543-2124651|CRISPRCasFinder
AGGAAGCCGTTGTCACGTGACAATCACTCCGTGCATGATGCAGGAAGCCGTTGTCACGTGACAATCACTCCGTGCACGATGCAGGAAGCCGTCGTCACGTGACAATCAC

>NZ_CP025931|6|6|2124543-2124651|CRISPRCasFinder
AGGAAGCCGTTGTCACGTGACAATCAC	TCCGTGCATGATGCAGGAAGCCGTTGTCACGTGACAATCACTCCGTGCACGATGC
AGGAAGCCGTCGTCACGTGACAATCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_013815252.1\|2117665_2119072_+\|sugar-transferase	unknown	unknown	gnl\|CDD\|274398
NZ_CP025931.1\|WP_143733548.1\|2132595_2132703_+\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_013815251.1\|2117093_2117669_+\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|376519
NZ_CP025931.1\|WP_004583623.1\|2112924_2113113_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|177033
NZ_CP025931.1\|WP_004583632.1\|2119068_2120865_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NZ_CP025931.1\|WP_021662107.1\|2126024_2126693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815249.1\|2116058_2116682_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|273496
NZ_CP025931.1\|WP_013815253.1\|2120825_2121890_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|182386
NZ_CP025931.1\|WP_013815254.1\|2121926_2122814_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP025931.1\|WP_021662106.1\|2126671_2127763_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_005874926.1\|2133707_2133998_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP025931.1\|WP_004583625.1\|2113594_2115862_-\|phosphate-transporter-family-protein	unknown	unknown	gnl\|CDD\|376541
NZ_CP025931.1\|WP_013815267.1\|2134017_2137113_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP025931.1\|WP_012458603.1\|2124828_2125881_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_004583624.1\|2113132_2113372_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP025931.1\|WP_013815263.1\|2131421_2132012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815262.1\|2129388_2131392_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378965
NZ_CP025931.1\|WP_013815268.1\|2137174_2137948_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|187792
NZ_CP025931.1\|WP_013815256.1\|2123320_2124223_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NZ_CP025931.1\|WP_013815261.1\|2127975_2129028_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_013815252.1\|2117665_2119072_+\|sugar-transferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.55214e-129
NZ_CP025931.1\|WP_143733548.1\|2132595_2132703_+\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000634986
NZ_CP025931.1\|WP_013815251.1\|2117093_2117669_+\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|376519	pfam01300, Sua5_yciO_yrdC, Telomere recombination. This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.	4.65026e-52
NZ_CP025931.1\|WP_004583623.1\|2112924_2113113_-\|50S-ribosomal-protein-L33	gnl\|CDD\|177033	CHL00104, rpl33, ribosomal protein L33.	1.21956e-18
NZ_CP025931.1\|WP_004583632.1\|2119068_2120865_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	9.43748e-102
NZ_CP025931.1\|WP_013815249.1\|2116058_2116682_-\|DNA-binding-protein	gnl\|CDD\|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	7.03433e-42
NZ_CP025931.1\|WP_013815253.1\|2120825_2121890_-\|mechanosensitive-ion-channel	gnl\|CDD\|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	1.49128e-59
NZ_CP025931.1\|WP_013815254.1\|2121926_2122814_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.69614e-15
NZ_CP025931.1\|WP_005874926.1\|2133707_2133998_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.2336e-16
NZ_CP025931.1\|WP_004583625.1\|2113594_2115862_-\|phosphate-transporter-family-protein	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	3.15944e-08
NZ_CP025931.1\|WP_013815267.1\|2134017_2137113_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.81881e-68
NZ_CP025931.1\|WP_004583624.1\|2113132_2113372_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	6.96682e-31
NZ_CP025931.1\|WP_013815268.1\|2137174_2137948_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.45991e-60
NZ_CP025931.1\|WP_013815262.1\|2129388_2131392_-\|hypothetical-protein	gnl\|CDD\|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	0.000696007
NZ_CP025931.1\|WP_013815256.1\|2123320_2124223_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	3.30199e-10

>NZ_CP025931.1|WP_013815256.1|2123320_2124223_-|T9SS-type-A-sorting-domain-containing-protein
MAFAQVPKGNDKSKDEHILTWALPEELVIDNNSIVATYNSFLTPFNGMTMACASFFDVQDLLPYVGYTINRIDFHPTADEKNYEQVAASKFYICIWGNKEQTEVLYEQALPTIHKEDLSFGYGVDGEEDYYDEPMYLAELETPFVIPAGKALYIGCRVETQEGHAVGFGLDDGPAMKGKGDLVGSYLPGAAPMPFVPLSDIPARSMDANFFIYSRISLGSGTQDILQHRMKVYPNPATTELHVEALSAWVGEQAAVYDMRGRRVSARMVDSEKLCIDIASLPAGVYVLRIGSYSAKFEKR
>NZ_CP025931.1|WP_013815254.1|2121926_2122814_+|tetratricopeptide-repeat-protein
MTDRFLHILRLSALCLLFSALLPPLFGQPTTTRQDSLPADYTRLIDRSFEALGQGNLELAEQALRQAIKAYPDLPSGYALMNNLGAIQQRQGKPEEALLTYSAALQKLPDDKLLRTNRAMLLTEMGRTDEAIFDYNELLRAEPDNEIFHYGRAMLYLAKGMYGDAESDLEEILRVNDSSLKARLGIALVATMKGEYDKAERLYNYVIDKLPKNAAAYEGRARLFLNKGMKGYALRDINKAFEYATPPAASLFVLRGEINAAIGDKKAAAEDYAVAESRGYSKESLDLLRAALRKQ
>NZ_CP025931.1|WP_013815253.1|2120825_2121890_-|mechanosensitive-ion-channel
MPADSVSAGLSASINDIKVTNRMGLKIFFPLQNLSVDTTKVNKIAEVVSPEALKQIKEIKPSQWTELLTQWGGKALSFGIKVLIALVAFYLGKLLLNALVKWLDRIMVRRSFEPAARTFLRSFANIGGFVLLIVIIISTLGFQPVSLAALLASVGVAVGMGLSGQLQNLAGGLIVLLTKPFKVGDYIVSNNVEGVVDGVTLFHTTVMTFENKYIFIPNGLLSSNVIINYSRMAVRRNEWIIGIEYNEDFDRVKTLLLRLIDEEPRIIKDPLPTVVLKELADSSVRVMARAWCATDDLWNVYWDINERIYSEFNRQGIAFPFPQLTIHGSAAGQERRGKSTEAQSPENVSTNTSL
>NZ_CP025931.1|WP_004583632.1|2119068_2120865_+|chloride-channel-protein
MKDKETSRYGWFLHFLLWRERHINERLFLIILSLIIGILSAFAAVLLKNTIHIIQHFAFDRIRETSYLYLIFPVVGILITWLFVRYVVRDDIGHGVTKILFAISQRKSRIKPHNMWSSLAASSITIGFGGSVGAESPIVLTGAAIGSNLGRLFRMEQKTLMLLVGCGAAGAISGIFKAPITGLVFVIEVLLLDLTMSSVLPLLISSVSAAAVSYIITGQGAMFSFTLNDPFSMDRIPYALLLGVFCGLVSFYFSKVMFVFESKLKNFPHYRQRYLISAFILCGLIFLFPPLYGEGYDTINALLGGQYSSLMDGSLFEPYSNSYWVLFVFLGFIIITKVFASVATNSGGGCGGLFAPSLFMGALSGFIFAYALNFFPFIEVYLPQKNFALLGMAGVMAAVMHAPLTGIFLIAELTGGYNLFLPLMLVSTSSYATIRLFMPHSIYSLRLAQKGKLLTHQKDKAVLTLMTLDAVIEKDFEPVRPDMTLGDVVHVFGISHRNVFPVLDENNLLMGLVLLDNIRNIMFRPELYERFKVSRFMVSPPAKIVNTMSMETIMRIFDDTKAWNLPVIDEQGCYLGFVSKSKIFNSYREVLVETFSGD
>NZ_CP025931.1|WP_013815252.1|2117665_2119072_+|sugar-transferase
MTRMQLHRLRYLLADVFGIVASYLSYNTLRYLTEEQERIYSTLSEYLFNAKSLWVGILYLLFWLSLFALSGYYNKPIAKSRISELLTTVASVLVGSVVVFLLLVVDDIVHDTALYLRLFFMMVATVLPWVYFPRLWVTTFGIKERKKTKGYHRVLLIGSGTIAEETASWLKSVNDMATTRLHFVPPTTREGFEQSLKSFATLVAEAVQESKPHQIILAVDCPDASFISLLLYQLYPFHMPVCVPMRSMLFAGAKVNVQGMKGEPMVDMTATNMSECAKSIKWFADRLFSLLMLILLIPVYAVIAVLVKRSSRGPVFFGQERIGLHGRPFTIYKFRTMYLDAEKDGPSLSFDGDSRVTPIGRILRKYRMDELPQFWNVLRGDMSFVGPRPERAFYIRQLVERAPYYYLLHNVRPGITSWGMVRYGYASTLDEMLERLQYDFLYYENMSLRLDIEVLLYTCQTIFKGLGK
>NZ_CP025931.1|WP_013815251.1|2117093_2117669_+|threonylcarbamoyl-AMP-synthase
MLNDIQRSEAKKAAEVMRKGGIILYPTDTIWGIGCDATNEEAVRRIYRLKERADSKSMLVLIDSEAKLQGLMDEVPELAWDLIELTTKPLTIIYPQAKGVAPALIASDGSLGIRLTRETFSAELCRLMRVPIVSTSANISGQPSARTFGEIAPAILDGVDYIVECRREEPAGQASSIIRLGTRGEVEVIRQ
>NZ_CP025931.1|WP_013815249.1|2116058_2116682_-|DNA-binding-protein
MAKFVMREMPDMQGTGKRTMYPKMISRGTMGLDEIADLISSQSTFSPGEVKGLVTALARTIAHGVASGYTVKIEEIGSFSASLTLHKGVEPEEAEGGTRRNAASVTIGGVNFRPDKALILEARTRVHLVRTTVRRPRRPNLTREERLALALRHLDGHSLLKVADYCRLTGLGRTAAAEELRAFDREGLIDSTGSGTHKVYIRNKAGI
>NZ_CP025931.1|WP_004583625.1|2113594_2115862_-|phosphate-transporter-family-protein
MSLIFTAIVVFLFILAIFDLIVGVSNDAVNFLNSAIGAKAAPFKIIVGVAALGVFCGAAMNNGMMEIARHGIFRPEHYTFSELMVVFLSVVITDVVLMDMFNSLGMPTSTTVSLIFELLGGSFFMAMTKVGGTVGFQDLLNTEKALSVILGIFLSVGIAFFFGMVVQYLSRLLFTFNYRRNLRWLAGLFGGVAVTSIIYFMLIKGLKGVSFMTEESTAWIAANTGRLVLYCLVVSIILMQVLYWLRVNVFKVIVLLGTFALAMAFAGNDLVNFIGVPLAGYSSYLDFNANGNGQYGTYLMGALNEPASTPVYFLVAAGIVMVYALITSKKAHNVIKTSVDLARQEEGEEMFGSSGLARSIVRFSTTTANAVSRIIPRPVGRWIDSRFNQDELIMAKGAAFDLVRASVNLVLAGLLIAFGTSLRLPLSTTYVAFMVAMGTSLADRAWSRESAVFRITGVFSVIGGWFITAGAAFILCFLVTMVNHFGGYPAMAGMIILAIFLLVRSHIRFDKKKKSETKDTVFIDMMASHDKEEIWQLLAKHIRQKQLALLDFAENNYMQMTDGFINEDLKRLRRSINDQNAERQMLKVNRRKETLGIRRIEEAKSVVKNTWFHLGCNSCEQIVFCLKRIAEPCKEHVDNNFNPLPKVCVSEFLAAREKLILYIKEAKLIVSNETDEILDPMTYRGKDIKKELKQLRKTQLSRIQQGASSLKISLVYLNLLQESQQLVNILDDLIHATEKLFDPVARIGTDEEFFN
>NZ_CP025931.1|WP_004583624.1|2113132_2113372_-|50S-ribosomal-protein-L28
MSKICQITGKKAMVGNNVSHSKRRTKRVFDVNLFRKKFYWVEQDCWVVLRISAAGLRLINKIGLDAAIKRAAEKGFLNA
>NZ_CP025931.1|WP_004583623.1|2112924_2113113_-|50S-ribosomal-protein-L33
MAKKVKGNRVQVILECTEHKESGMPGISRYITTKNRKNTTQRLELKKYNPILRRMTLHKEIK
>NZ_CP025931.1|WP_012458603.1|2124828_2125881_+|hypothetical-protein
MTVENLRLQRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSQLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NZ_CP025931.1|WP_021662107.1|2126024_2126693_-|hypothetical-protein
METIRKITKWYLFVFALLAITIPSLAQETSKSEGLILSSSFRMGVPMLVSNLSLLDERAPLANNPGVAASVELSYKKFADRTSLGLLVDLGLYNNRIASFISGNNIGIENNVFNTFAGIVIRHYHIDNDRIELAAPIAIGYMHTWNFEDRQDLAGGVISRTKSMGAFAMTAGMELGFKVKEGKCIGAKVDLSAAVGKSMVDASKKMRCWLSPSIGLFFRHSL
>NZ_CP025931.1|WP_021662106.1|2126671_2127763_-|hypothetical-protein
MQNAQSEKNLKIFFDGNKIFLLLPRISKFRIRRCRNIIPKYSKMKKSFVVGASLCIAAIFSLVSCSKQEIEEVRVMENETIKTDLPQARSIEDSVALAELVLDLETYNSSLDSDGRSTYSAGQQTFSVEGQLMNNRSFWSFFKKIAKAVAVVSADAIGVCVGSTIHPAMGVAFCATASAGTSVLLDADINVSFLKESFGPDITRSNYGVWHNNTIAAYLNEHGSLTNLDPLQFYNYSLTYCSNNIGSSTSRPLPYEKVETLCSALAQLFTSLENDNSEKTEEEICNMIVSAVPEIRAQEVKILLNFLLKMYSPDFKVEKRREYIAGHTEVVFQSRLSEAGKKRIYDMLSVACNSSLLWKQSEK
>NZ_CP025931.1|WP_013815261.1|2127975_2129028_+|hypothetical-protein
MTAEIFSFSRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSKLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NZ_CP025931.1|WP_013815262.1|2129388_2131392_-|hypothetical-protein
MKPLLTVVCAILLSLPLGGQTVVPEWDEYIAEQIESGALGEDEGAEFLERWMVQKQHPLDINTLTREDLEQFPFLNEFQIRRFLLYRHAHPEGFDSIWVLNEIAGWDRRTCLLLWPMLTVQKRSEPAVGSFREILSYARHDVSVHTDAILQRQEGYRPDSRHPYRGDPWGGGLRWSYAMGNRFSLGLTASKDRGEPAFDKRRKGFDSYSAHFFMEGKGAVRAVALGDYRIGMGYGLLVNQASFMGMAYAYPRGGTTLRRAFTYAEDNFMRGAATALAQGRWALTAFYSRKGVDATVTEDGAIKAIYHTGLHRTDAEIVRRNAATMTTAGTSVSYTDDRLRLTFNLLHLHWGGLRLLRAVGTQGIASLTDLERFSLVSADYSYLFGQGGTELFGEFAGAANGAVGTINGLRYTHPVGGSYMLVGRYIPADYWSYYRGAFARHSRPGNEWGVMGRAAWELPSDRTVRAFADYYGSFVPRFGRKEKTEALYWMFEGEKRLSALSWSCRIRGTADKRYRRSLAVRLRGRYTFDERWRLMASLQWSRSNSFDRELQTWQAPTGGKSFALRADYSGGKLLRLCSMDAVAFDTDSFADRLYEAVHNPRHHYSSAFFYGRGVRLGMFVRIAPLPHVEIESRTDHLLRRDTDTIGSAGELIRGQARTHLFMTVRYR
>NZ_CP025931.1|WP_013815263.1|2131421_2132012_-|hypothetical-protein
MKRTLVFLFLTAVLALRAEAQSAPEQSETKDFIFSPQKEKVYVAIGYPAGIGLPSLDNYNVEGASASFAVGYERGVKQLAEGLLLSIYAELDWAAFRSVSDKRSLPFSDDSAQNRFRFLAGAGVHKRLNPNIELYARGAVGASFFPENNGSSSRELKGGFNVSLRVGLSCSLRDNFAVFIDTGTSDIVRGGLALMW
>NZ_CP025931.1|WP_143733548.1|2132595_2132703_+|DUF1661-domain-containing-protein
MAREFFTSRTKTKKFPRHVFQSIDSLLQRVRYPLL
>NZ_CP025931.1|WP_005874926.1|2133707_2133998_-|CRISPR-associated-endonuclease-Cas2
MNDKKLLVAYDISSNRRRRKVARILEQCGIRINKSVFICSLRELTMDKLVEAVTSQTAKRDKVFFLPLCQHCYTAAWMSGHPTLPKSRRKRKSIVV
>NZ_CP025931.1|WP_013815267.1|2134017_2137113_-|CRISPR-associated-endonuclease-Cas1
MPLSTDSLPIFLSDFTAYHFSVRFRAERAIAFERKWYFMPRFALGNALKNSEQYAYLYGQIFKPQEEDTDESKGPGNTSRLIIRADKPSRKSLEAGEAMDLYITVVTRDPLLVGDFLSFLPEWQAYNFFRENDLTYDSYRLYNPTTQKYESGLRVEDAALTVDFFSRQAIRWGEILSVRFLSPASIKVDQILSAEIPYSRLMNRLSRRLYELYTQYLSRGETSVERYIFPDHDGLIYSQISMPRKATIKENRQYDMSGILGQLFYRVPYDPVAALMLSMAHWVHIGNHTIVGNGQIESTPCNDTLYRKWLSSLAADRDLPMAETERQDLLEALRICSYIPQPYHSVNIPKGDGSYRQLHIPSAVDLHLQRSLAGILYPITESLSIAQSYAYRKGKGAVAAVRRVQHLLDSLDENYTVVRCDIDNFFDSIPVPSLLQKVQRTTEDPLLTRMLSLWMKSGVVDRKQQYAPASSGIPQGSPLALLLSNLYLEDTDRYIAGHITTEFIRYADDLLLFLPEKVDPLNALQDLSEHLKYRKGLKLNRDFVVSSIKSSFSFLGITFCADGSRSMSRDKKEGLKRKITLALHRDTENFSALSETIHGMEQYYRKLLEKVDIEAIDEVAATVYATYIASLPTSEARKSAKDNLLRLGFLSSETAKQTLREAMRQTEVSSADNFPIKKESEILREQQKRQLQERGEIFDLVVTEPGAFIGISRNHVLVRKYGKTICKQPAAQIEQISIISDGVSLSSNVTKYCRKKNIRVIFYNATGQAYASLNGMNTILPSVMEAQMRLSEEKKREFILTLIKNKVRNQGKLLRYYHKYYRHDKELKEPLSNAIAELKQLEGIPIAEGSSLADFRQHAMLHEARCAQVYWRAFALLVHRSGHEFEGREHKGAEGLVNQMLNYGYAILRSYVMKTIDLWQLNPNIGILHSTQDNKPALCFDLMEQYRAFVVDRSILALLAKGEDVGQNNKGLLDMPTRSRIISKINERWFATEYYRSGEKLFSDIMKLQTKDVRAFCCGKVKRIKFYTPKW
>NZ_CP025931.1|WP_013815268.1|2137174_2137948_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MNFGHWYYREYFDTINLDSKGIVTNFSTFNKGKNDKLIKGATLPPYDKENDIEDVTSFELKTCYPGLLCGVGYHHEINNPKNEPKEDDAPEVYNLGMYFDYTSGLPVIPGSSIKGMLRSAIEEWDFLADYKPQEKNTPPASLSDKKVLHEEIIKTVFEGKGLSIYDRDIFLDAIPIRVDNKLFGEDYITHHPTPLQNPNPVRFLRVNPGVTYQFRFILRNNDNGLKADFKEDLFKAIICTFGLGAKTNVGYGQFVEH

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Crispr_ID: NZ_CP025931_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_7

2132965-2133307

TypeIII

Consensus_repeat	Method
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	PILER-CR
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CRISPRCasFinder
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CRT

4 spacers

cas2,cas1,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7

The CRISPR arrays of NZ_CP025931_7

>merge|NZ_CP025931|7|2132965-2133307|PILER-CR,CRISPRCasFinder,CRT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGCCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTTGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGTATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGAGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGCGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGGGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGCGTATATCCGGCATTAGTAGGAGAGGTTATGATAAGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

>NZ_CP025931|7|2|2132965-2133307|PILER-CR
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

>NZ_CP025931|7|7|2132965-2133307|CRISPRCasFinder
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

>NZ_CP025931|7|2|2132965-2133307|CRT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_013815269.1\|2137944_2138382_-\|hypothetical-protein	cmr5gr11	mkCas0098_cmr5gr11_CAS-III-B	unknown
NZ_CP025931.1\|WP_005874926.1\|2133707_2133998_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP025931.1\|WP_005874934.1\|2143406_2143658_-\|hypothetical-protein	cmr1gr7	mkCas0102_cmr1gr7_CAS-III-B	unknown
NZ_CP025931.1\|WP_013815271.1\|2139093_2140305_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09656_cmr3gr5_CAS-III-B	gnl\|CDD\|273855
NZ_CP025931.1\|WP_143733548.1\|2132595_2132703_+\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_021662107.1\|2126024_2126693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815254.1\|2121926_2122814_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP025931.1\|WP_013815263.1\|2131421_2132012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815272.1\|2140306_2141956_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl\|CDD\|274208
NZ_CP025931.1\|WP_013815262.1\|2129388_2131392_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378965
NZ_CP025931.1\|WP_021662106.1\|2126671_2127763_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815270.1\|2138378_2139080_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|187813
NZ_CP025931.1\|WP_013815273.1\|2141948_2143400_-\|hypothetical-protein	cmr1gr7	mkCas0086_cmr1gr7_CAS-III-B	unknown
NZ_CP025931.1\|WP_013815253.1\|2120825_2121890_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|182386
NZ_CP025931.1\|WP_012458603.1\|2124828_2125881_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815267.1\|2134017_2137113_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP025931.1\|WP_005874939.1\|2143659_2145243_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815268.1\|2137174_2137948_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|187792
NZ_CP025931.1\|WP_013815256.1\|2123320_2124223_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NZ_CP025931.1\|WP_013815261.1\|2127975_2129028_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_013815272.1\|2140306_2141956_-\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	1.75135e-95
NZ_CP025931.1\|WP_013815262.1\|2129388_2131392_-\|hypothetical-protein	gnl\|CDD\|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	0.000696007
NZ_CP025931.1\|WP_013815268.1\|2137174_2137948_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl\|CDD\|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.45991e-60
NZ_CP025931.1\|WP_005874926.1\|2133707_2133998_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.2336e-16
NZ_CP025931.1\|WP_013815271.1\|2139093_2140305_-\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|273855	TIGR01888, Hypothetical_protein_SSO1730, CRISPR type III-B/RAMP module-associated protein Cmr3. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family is found in at least ten different archaeal and bacterial species as part of the CRISPR RAMP modulue but is not a member of the RAMP superfamily itself. A typical example is TM1793 from Thermotoga maritima.	6.74082e-71
NZ_CP025931.1\|WP_013815267.1\|2134017_2137113_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.81881e-68
NZ_CP025931.1\|WP_013815270.1\|2138378_2139080_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|187813	cd09682, Cmr4_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	3.5941e-85
NZ_CP025931.1\|WP_143733548.1\|2132595_2132703_+\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000634986
NZ_CP025931.1\|WP_013815254.1\|2121926_2122814_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.69614e-15
NZ_CP025931.1\|WP_013815256.1\|2123320_2124223_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	3.30199e-10
NZ_CP025931.1\|WP_013815253.1\|2120825_2121890_-\|mechanosensitive-ion-channel	gnl\|CDD\|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	1.49128e-59

>NZ_CP025931.1|WP_143733548.1|2132595_2132703_+|DUF1661-domain-containing-protein
MAREFFTSRTKTKKFPRHVFQSIDSLLQRVRYPLL
>NZ_CP025931.1|WP_013815263.1|2131421_2132012_-|hypothetical-protein
MKRTLVFLFLTAVLALRAEAQSAPEQSETKDFIFSPQKEKVYVAIGYPAGIGLPSLDNYNVEGASASFAVGYERGVKQLAEGLLLSIYAELDWAAFRSVSDKRSLPFSDDSAQNRFRFLAGAGVHKRLNPNIELYARGAVGASFFPENNGSSSRELKGGFNVSLRVGLSCSLRDNFAVFIDTGTSDIVRGGLALMW
>NZ_CP025931.1|WP_013815262.1|2129388_2131392_-|hypothetical-protein
MKPLLTVVCAILLSLPLGGQTVVPEWDEYIAEQIESGALGEDEGAEFLERWMVQKQHPLDINTLTREDLEQFPFLNEFQIRRFLLYRHAHPEGFDSIWVLNEIAGWDRRTCLLLWPMLTVQKRSEPAVGSFREILSYARHDVSVHTDAILQRQEGYRPDSRHPYRGDPWGGGLRWSYAMGNRFSLGLTASKDRGEPAFDKRRKGFDSYSAHFFMEGKGAVRAVALGDYRIGMGYGLLVNQASFMGMAYAYPRGGTTLRRAFTYAEDNFMRGAATALAQGRWALTAFYSRKGVDATVTEDGAIKAIYHTGLHRTDAEIVRRNAATMTTAGTSVSYTDDRLRLTFNLLHLHWGGLRLLRAVGTQGIASLTDLERFSLVSADYSYLFGQGGTELFGEFAGAANGAVGTINGLRYTHPVGGSYMLVGRYIPADYWSYYRGAFARHSRPGNEWGVMGRAAWELPSDRTVRAFADYYGSFVPRFGRKEKTEALYWMFEGEKRLSALSWSCRIRGTADKRYRRSLAVRLRGRYTFDERWRLMASLQWSRSNSFDRELQTWQAPTGGKSFALRADYSGGKLLRLCSMDAVAFDTDSFADRLYEAVHNPRHHYSSAFFYGRGVRLGMFVRIAPLPHVEIESRTDHLLRRDTDTIGSAGELIRGQARTHLFMTVRYR
>NZ_CP025931.1|WP_013815261.1|2127975_2129028_+|hypothetical-protein
MTAEIFSFSRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSKLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NZ_CP025931.1|WP_021662106.1|2126671_2127763_-|hypothetical-protein
MQNAQSEKNLKIFFDGNKIFLLLPRISKFRIRRCRNIIPKYSKMKKSFVVGASLCIAAIFSLVSCSKQEIEEVRVMENETIKTDLPQARSIEDSVALAELVLDLETYNSSLDSDGRSTYSAGQQTFSVEGQLMNNRSFWSFFKKIAKAVAVVSADAIGVCVGSTIHPAMGVAFCATASAGTSVLLDADINVSFLKESFGPDITRSNYGVWHNNTIAAYLNEHGSLTNLDPLQFYNYSLTYCSNNIGSSTSRPLPYEKVETLCSALAQLFTSLENDNSEKTEEEICNMIVSAVPEIRAQEVKILLNFLLKMYSPDFKVEKRREYIAGHTEVVFQSRLSEAGKKRIYDMLSVACNSSLLWKQSEK
>NZ_CP025931.1|WP_021662107.1|2126024_2126693_-|hypothetical-protein
METIRKITKWYLFVFALLAITIPSLAQETSKSEGLILSSSFRMGVPMLVSNLSLLDERAPLANNPGVAASVELSYKKFADRTSLGLLVDLGLYNNRIASFISGNNIGIENNVFNTFAGIVIRHYHIDNDRIELAAPIAIGYMHTWNFEDRQDLAGGVISRTKSMGAFAMTAGMELGFKVKEGKCIGAKVDLSAAVGKSMVDASKKMRCWLSPSIGLFFRHSL
>NZ_CP025931.1|WP_012458603.1|2124828_2125881_+|hypothetical-protein
MTVENLRLQRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSQLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NZ_CP025931.1|WP_013815256.1|2123320_2124223_-|T9SS-type-A-sorting-domain-containing-protein
MAFAQVPKGNDKSKDEHILTWALPEELVIDNNSIVATYNSFLTPFNGMTMACASFFDVQDLLPYVGYTINRIDFHPTADEKNYEQVAASKFYICIWGNKEQTEVLYEQALPTIHKEDLSFGYGVDGEEDYYDEPMYLAELETPFVIPAGKALYIGCRVETQEGHAVGFGLDDGPAMKGKGDLVGSYLPGAAPMPFVPLSDIPARSMDANFFIYSRISLGSGTQDILQHRMKVYPNPATTELHVEALSAWVGEQAAVYDMRGRRVSARMVDSEKLCIDIASLPAGVYVLRIGSYSAKFEKR
>NZ_CP025931.1|WP_013815254.1|2121926_2122814_+|tetratricopeptide-repeat-protein
MTDRFLHILRLSALCLLFSALLPPLFGQPTTTRQDSLPADYTRLIDRSFEALGQGNLELAEQALRQAIKAYPDLPSGYALMNNLGAIQQRQGKPEEALLTYSAALQKLPDDKLLRTNRAMLLTEMGRTDEAIFDYNELLRAEPDNEIFHYGRAMLYLAKGMYGDAESDLEEILRVNDSSLKARLGIALVATMKGEYDKAERLYNYVIDKLPKNAAAYEGRARLFLNKGMKGYALRDINKAFEYATPPAASLFVLRGEINAAIGDKKAAAEDYAVAESRGYSKESLDLLRAALRKQ
>NZ_CP025931.1|WP_013815253.1|2120825_2121890_-|mechanosensitive-ion-channel
MPADSVSAGLSASINDIKVTNRMGLKIFFPLQNLSVDTTKVNKIAEVVSPEALKQIKEIKPSQWTELLTQWGGKALSFGIKVLIALVAFYLGKLLLNALVKWLDRIMVRRSFEPAARTFLRSFANIGGFVLLIVIIISTLGFQPVSLAALLASVGVAVGMGLSGQLQNLAGGLIVLLTKPFKVGDYIVSNNVEGVVDGVTLFHTTVMTFENKYIFIPNGLLSSNVIINYSRMAVRRNEWIIGIEYNEDFDRVKTLLLRLIDEEPRIIKDPLPTVVLKELADSSVRVMARAWCATDDLWNVYWDINERIYSEFNRQGIAFPFPQLTIHGSAAGQERRGKSTEAQSPENVSTNTSL
>NZ_CP025931.1|WP_005874926.1|2133707_2133998_-|CRISPR-associated-endonuclease-Cas2
MNDKKLLVAYDISSNRRRRKVARILEQCGIRINKSVFICSLRELTMDKLVEAVTSQTAKRDKVFFLPLCQHCYTAAWMSGHPTLPKSRRKRKSIVV
>NZ_CP025931.1|WP_013815267.1|2134017_2137113_-|CRISPR-associated-endonuclease-Cas1
MPLSTDSLPIFLSDFTAYHFSVRFRAERAIAFERKWYFMPRFALGNALKNSEQYAYLYGQIFKPQEEDTDESKGPGNTSRLIIRADKPSRKSLEAGEAMDLYITVVTRDPLLVGDFLSFLPEWQAYNFFRENDLTYDSYRLYNPTTQKYESGLRVEDAALTVDFFSRQAIRWGEILSVRFLSPASIKVDQILSAEIPYSRLMNRLSRRLYELYTQYLSRGETSVERYIFPDHDGLIYSQISMPRKATIKENRQYDMSGILGQLFYRVPYDPVAALMLSMAHWVHIGNHTIVGNGQIESTPCNDTLYRKWLSSLAADRDLPMAETERQDLLEALRICSYIPQPYHSVNIPKGDGSYRQLHIPSAVDLHLQRSLAGILYPITESLSIAQSYAYRKGKGAVAAVRRVQHLLDSLDENYTVVRCDIDNFFDSIPVPSLLQKVQRTTEDPLLTRMLSLWMKSGVVDRKQQYAPASSGIPQGSPLALLLSNLYLEDTDRYIAGHITTEFIRYADDLLLFLPEKVDPLNALQDLSEHLKYRKGLKLNRDFVVSSIKSSFSFLGITFCADGSRSMSRDKKEGLKRKITLALHRDTENFSALSETIHGMEQYYRKLLEKVDIEAIDEVAATVYATYIASLPTSEARKSAKDNLLRLGFLSSETAKQTLREAMRQTEVSSADNFPIKKESEILREQQKRQLQERGEIFDLVVTEPGAFIGISRNHVLVRKYGKTICKQPAAQIEQISIISDGVSLSSNVTKYCRKKNIRVIFYNATGQAYASLNGMNTILPSVMEAQMRLSEEKKREFILTLIKNKVRNQGKLLRYYHKYYRHDKELKEPLSNAIAELKQLEGIPIAEGSSLADFRQHAMLHEARCAQVYWRAFALLVHRSGHEFEGREHKGAEGLVNQMLNYGYAILRSYVMKTIDLWQLNPNIGILHSTQDNKPALCFDLMEQYRAFVVDRSILALLAKGEDVGQNNKGLLDMPTRSRIISKINERWFATEYYRSGEKLFSDIMKLQTKDVRAFCCGKVKRIKFYTPKW
>NZ_CP025931.1|WP_013815268.1|2137174_2137948_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MNFGHWYYREYFDTINLDSKGIVTNFSTFNKGKNDKLIKGATLPPYDKENDIEDVTSFELKTCYPGLLCGVGYHHEINNPKNEPKEDDAPEVYNLGMYFDYTSGLPVIPGSSIKGMLRSAIEEWDFLADYKPQEKNTPPASLSDKKVLHEEIIKTVFEGKGLSIYDRDIFLDAIPIRVDNKLFGEDYITHHPTPLQNPNPVRFLRVNPGVTYQFRFILRNNDNGLKADFKEDLFKAIICTFGLGAKTNVGYGQFVEH
>NZ_CP025931.1|WP_013815269.1|2137944_2138382_-|hypothetical-protein
MNKKTIQDLIPKAMQAIEGVGIVGKDKKFKKVHEGYINALGPNIIQSGLLPTLIFYNKDERALWLRALYYMAVGEEDEMTDESSTVIIRLIIGKEGGRIENLKPKAKEWERKILEYAVALKLALRTFVAEEAETSNTKQQEGGAQ
>NZ_CP025931.1|WP_013815270.1|2138378_2139080_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MKTAAYMIHCLTNMHVGKGDATYEVVDKCVQRDVTTGMPCIYSSSLKGALRQFFSKQGFAELNYVFGKDQSRDKKNNGNEKNEEEHSVGNFTFFQANLLAYPVQTTREGATYILKTNKALQESIKELAKLLSAPSNIEDLLPEGIEKDLSNEALEQLPVIARNQLDNGKSENLWYEEVVPAESRFVFFVSYDDEEIFAKFDKIIQEKVIQIGANGSIGYGFCKIANVTNPFKK
>NZ_CP025931.1|WP_013815271.1|2139093_2140305_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MSTYLIKLTPLDKFFFGQKKTFGDDNANYFVYSSHFPQQTALLGLLRYQLLQIAGEEIFKDNKIQDEHKAGELIGKQSFSPFVKDKLQFGIIQSLSPVFIIDKKKDEGKEEYFLPVGKRFQKKKEKAPYSLLHLSCEDECPPIFESRESQKEKEEAYDPKKGLASCWLSSKSHTLLNEEDFFTKDERIGIRKDYEGATNDDAFFCQRYYRFKNFKKVVEDEEGNECKQPPVRVHDFCFATVLETEKAIEHEKLNGKIVYLGGERQPFLMEVSEETFKLNIESSTLTSDEKHYTVVLLSDAMIDPDHLSKVRFASTEVKDFACLLTHVGTQKFYNKENKRQEQYLKKSATALSLQKELYARGSVFYFDTKEQANQFCEDLEKVPNFHTIGYNHAIIIEPTKTKK
>NZ_CP025931.1|WP_013815272.1|2140306_2141956_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MSNEIYTAITIGPICKTLDKARSVKSFWTASYLFSWIMRELLERLPKEERPEGSFEVLSPHRDGKDVPEETSKKVGLFPDRLFAKGELEEEKLQEIKGKIFIELAEKFKNAFQDEKDGITRKIDTESDPKRKRELEEIQSRYSNAALKGEDIRKYLENYLSISCITVELSSDCNILEQLNSYLDTQELFNKASIQTDEDYMELFIEAPNNTFLKAYSQDRAFPSTSEIAVSGWEQDPPKDENGEVEYTQLTSKPGFRNCYKYLAVIKADGDGFGTYIKELKVDEEKEIKENGEKENELSRFTKSFFEFSVEVANELIQKTKAIPVYIGGDDLFLFAPVLEGNVEKDVFNLIKEIDDLFIQKEIGEGLSMSYGVSIFYYKSPMSEAIDIADSMLRKAKEEKEEKEKKKDAVAISIQKHSGQKIEFLLPCKHSSADETDRKESLYGKTVELVRAFKGDGNMLNSLIYWIEEMYEILFIEEVTQSQERINAVFDNFFDEEIHKENEVFFDLLKDFIHSMHRSEDAPRKLSDKKELLHGILRYCQFVTAKKEK
>NZ_CP025931.1|WP_013815273.1|2141948_2143400_-|hypothetical-protein
MYKLEFELEQHTPIIHFQARDAGATLRASEVKPKLDKFILTQIGKRFVKKTASTTEKNFIERGIEYFQNKDEEARRVYEEEKKKGNKDAKLELCLIPGQEGALNYKLSFKLSPDAKVQYFLPMSSNPKEIDKLKSLAQEKLGVQGVEILPLTSYFANEDKAKSEPNIKRGDTPSQIKNKKRIFEKNWQKVQLATFVNTPVEGVIRFQNAGLREEVNNLITNFFMLHNFGARQSKGFGSFIISLRDGKEEEDYFDTGCACYGYSFYIPAKTLEEALRKINYFYRSLRSGFNEYRGKNEIFYAKSGMHFYATKHNFEWDKKSIKGMLFDRDKDLEGKMKKEELFAFRDLLGLSSNERWQSYKTTITKECRNKKGEKFDRIKSPIQFKPICYSKYDYIVFFDLFPEKSGIPQLKGGKVVVKSSRHKGAVLELKIQEDIDLYNVFNEIFSELNFESQVGEYDSLTDAKEIFETMKDIYEQLNKNCHE
>NZ_CP025931.1|WP_005874934.1|2143406_2143658_-|hypothetical-protein
MEIETLILLCFVVVATATIIVVAIIWSYKLKIKKEELRDKTLFELERERTKDLNKWQSFSESLLETNKGLMEVYCKDNTKQKA
>NZ_CP025931.1|WP_005874939.1|2143659_2145243_-|hypothetical-protein
MEAETYSRHIFIFPFQWDYIEKRGYASYNERTDIKKFDKLFSAVSPLKRQYFEIGASEERYNEYTYFHPFARRALFGTKENPSVYHYELSDTQGSYNISVKIDGVSTTYSLQLEKIAVSVFDTGVGTVAYFLRNDKHTSFEDILRINDSGRRIYPQYMAKGDRLAAKNSFLADRIYGSLGVLDFDDDFRQFEEDISHTNIFLPPDHIRQVFGYNKMDRTEDDGCQKFVFHQESERKDIIRISPVMDDRMFFITYYHSPYYAKKLRSKPKNFRRKREYNIYEEGRFGDLWFRYIFGDRGDKTVANTSVQREDVRRTTYARWSGEGTLFGLTKDSLVGISGWELMGDHITTMYYQMATLSLVQRSTILRFSNEIASITQLILDKKTKRKTEKQVKELYGNYIRFLNETYFREVTPQIQGIEMYDMLQSNMNIEKDAKALDEEMGELFNYTTLEEQGVLNKTANLYLPITLLVGFLGINTFVEKGCITRFFNIGDPCPSTWGLLGGDIITLIVFAICLYFPIRHYFKYRK

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Crispr_ID: NZ_CP025931_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025931_8

2166942-2171252

Unclear

Consensus_repeat	Method
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CRISPRCasFinder
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CRT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	PILER-CR

65 spacers

cas2,cas1,cas4,cas3,cas7b,cas8b4,cas5,cas6

The CRISPR arrays of NZ_CP025931_8

>merge|NZ_CP025931|8|2166942-2171252|CRISPRCasFinder,CRT,PILER-CR
GTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCGTAACAGCAGGGATGAACTATGCGCTGCACGGTTTTAATTCCTGTATGGTGCAATTGAAATCGTTATACCTTCTATCGTCTTCAAATCTAAGGATGTTTTAATTCCTGTATGGTGCAATTGAAATGGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCGGTTTTAATTCCTGTATGGTGCAATTGAAATCCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAGGTTTTAATTCCTGTATGGTGCAATTGAAATAATACGTAGGAGGCGGACTATGATAGTAGCGATTATGTTTTAATTCCTGTATGGTGCAATTGAAATCGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAGGTTTTAATTCCTGTATGGTGCAATTGAAATTTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCAGTTTTAATTCCTGTATGGTGCAATTGAAATATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAAGTTTTAATTCCTGTATGGTGCAATTGAAATTAAATAATCATTTAATTGTAACATTTTGTGAATAGTTTTAATTCCTGTATGGTGCAATTGAAATATAGTATCACACAACATCAAATGTTAGATGGATATGTTTTAATTCCTGTATGGTGCAATTGAAATTTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAAGTTTTAATTCCTGTATGGTGCAATTGAAATCTTTGTAGATTTATCGGATTATTTCGATATTATAAGTTTTAATTCCTGTATGGTGCAATTGAAATTTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGCGTTTTAATTCCTGTATGGTGCAATTGAAATAGTATGCCTGACACGCGAGATCGCACCTTGTCGAGGGTTTTAATTCCTGTATGGTGCAATTGAAATACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGAGTTTTAATTCCTGTATGGTGCAATTGAAATACTATTCGGGAGGGAAGATATACAACGAGACCGATGTTTTAATTCCTGTATGGTGCAATTGAAATACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGCGTTTTAATTCCTGTATGGTGCAATTGAAATCTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTGGTTTTAATTCCTGTATGGTGCAATTGAAATGCATTCGCGATTTTTCCGACCTCGAACGAATCGTATGTTTTAATTCCTGTATGGTGCAATTGAAATGACGCAGGCGCGGGCGGACGTGTATAAAAAGTACTGTTTTAATTCCTGTATGGTGCAATTGAAATTTCGGTGGCATCGTCTTCGTTCGCATACAGAACGTGTTTTAATTCCTGTATGGTGCAATTGAAATATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCTGTTTTAATTCCTGTATGGTGCAATTGAAATTGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCTGTTTTAATTCCTGTATGGTGCAATTGAAATGTGAACGGAGCGTCGAAACAATGCCACGTTCCGAAGTTTTAATTCCTGTATGGTGCAATTGAAATCCGAGCGATAAGACCACATAAGGAGAAACGATCCGCTGTTTTAATTCCTGTATGGTGCAATTGAAATACCTGCAATAGATATACGACATAATTTCGTATTGCAGTTTTAATTCCTGTATGGTGCAATTGAAATCCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTAGTTTTAATTCCTGTATGGTGCAATTGAAATAGTAATTATTCAAATTTCTTGTTTATCGGATCTCTGTTTTAATTCCTGTATGGTGCAATTGAAATGAGGCCTCATTCGGCTCTATCTTCGCACCCGACACGTTTTAATTCCTGTATGGTGCAATTGAAATTGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACATGTTTTAATTCCTGTATGGTGCAATTGAAATCCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAAGTTTTAATTCCTGTATGGTGCAATTGAAATTCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAGGTTTTAATTCCTGTATGGTGCAATTGAAATGCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCAGTTTTAATTCCTGTATGGTGCAATTGAAATGCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCAGTTTTAATTCCTGTATGGTGCAATTGAAATGTGATACGATTAATACGTTAGCGTTATTCTTCATGGTTTTAATTCCTGTATGGTGCAATTGAAATTTCTTTATCGTGATATTTTGTCCGCTCTTTTTGACGTTTTAATTCCTGTATGGTGCAATTGAAATAGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACAGTTTTAATTCCTGTATGGTGCAATTGAAATTTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTTGTTTTAATTCCTGTATGGTGCAATTGAAATTAAATGCGTTCTCAATCACACCAATCTTGCCGGCGTTTTAATTCCTGTATGGTGCAATTGAAATCGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCCGTTTTAATTCCTGTATGGTGCAATTGAAATATCCACATTAGACGCATTCGCACTCGTCCAGCCCGGTTTTAATTCCTGTATGGTGCAATTGAAATCTGATGACATACAAAGAGTATATCGCGGCAATGGTGTTTTAATTCCTGTATGGTGCAATTGAAATTATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGTGTTTTAATTCCTGTATGGTGCAATTGAAATATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAGGTTTTAATTCCTGTATGGTGCAATTGAAATCCTTCTACGATTACTGCCATTTACTTTACTTTTTTTGTTTTAATTCCTGTATGGTGCAATTGAAATTAATAGTCCACACCCCAACGCCAAAGGATGAATCGGTTTTAATTCCTGTATGGTGCAATTGAAATCGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCGGTTTTAATTCCTGTATGGTGCAATTGAAATAACGTCGATGTCTCAGGCGACTATGGCACAGCCACAGTTTTAATTCCTGTATGGTGCAATTGAAATCGACATGCCACCCGCAGGACACGATATGCCGCGAGAGTTTTAATTCCTGTATGGTGCAATTGAAATGCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGAGTTTTAATTCCTGTATGGTGCAATTGAAATGCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGAGTTTTAATTCCTGTATGGTGCAATTGAAATCCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGACGTTTTAATTCCTGTATGGTGCAATTGAAATGTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCGGTTTTAATTCCTGTATGGTGCAATTGAAATCCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTAGTTTTAATTCCTGTATGGTGCAATTGAAATTTTCTCTGACATTAAAATAGAAATCATCGCTGAAGAGTTTTAATTCCTGTATGGTGCAATTGAAATCCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGCGTTTTAATTCCTGTATGGTGCAATTGAAATAGGGCTGACGTGTATAAAAAATACCTGGGGGATAATGTTTTAATTCCTGTATGGTGCAATTGAAATCTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCTGTTTTAATTCCTGTATGGTGCAATTGAAATACTTCGCCGTCCGCGGTAATGTGACCAATACCGACGTTTTAATTCCTGTATGGTGCAATTGAAATCACCCACCCACGCCAGCACCCTCTGCCACCAGCGCGTTTTAATTCCTGTATGGTGCAATTGAAATAACTCAAAAAAACTACAATAAATATGCCAACAGTAGTGTTTTAATTCCTGTATGGTGCAATTGAAAT

>NZ_CP025931|8|8|2166942-2171252|CRISPRCasFinder
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCGTAACAGCAGGGATGAACTATGCGCTGCACG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATAATCATTTAATTGTAACATTTTGTGAATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATAGTATCACACAACATCAAATGTTAGATGGATAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTTGTAGATTTATCGGATTATTTCGATATTATAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACCTGCAATAGATATACGACATAATTTCGTATTGCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGATACGATTAATACGTTAGCGTTATTCTTCATG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTGATGACATACAAAGAGTATATCGCGGCAATGGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

>NZ_CP025931|8|3|2166942-2171252|CRT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCGTAACAGCAGGGATGAACTATGCGCTGCACG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATAATCATTTAATTGTAACATTTTGTGAATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATAGTATCACACAACATCAAATGTTAGATGGATAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTTGTAGATTTATCGGATTATTTCGATATTATAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACCTGCAATAGATATACGACATAATTTCGTATTGCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGATACGATTAATACGTTAGCGTTATTCTTCATG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTGATGACATACAAAGAGTATATCGCGGCAATGGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

>NZ_CP025931|8|3|2167271-2171252|PILER-CR
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATAATCATTTAATTGTAACATTTTGTGAATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATAGTATCACACAACATCAAATGTTAGATGGATAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTTGTAGATTTATCGGATTATTTCGATATTATAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACCTGCAATAGATATACGACATAATTTCGTATTGCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGATACGATTAATACGTTAGCGTTATTCTTCATG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTGATGACATACAAAGAGTATATCGCGGCAATGGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025931.1\|WP_004583651.1\|2153982_2155380_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|182787
NZ_CP025931.1\|WP_013815290.1\|2163708_2165457_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP025931.1\|WP_013815291.1\|2165715_2166801_-\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|377531
NZ_CP025931.1\|WP_013815300.1\|2178862_2179528_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP025931.1\|WP_013815288.1\|2159827_2162329_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP025931.1\|WP_005874903.1\|2159161_2159521_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025931.1\|WP_013815285.1\|2156172_2157516_-\|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein	unknown	unknown	gnl\|CDD\|273571
NZ_CP025931.1\|WP_013815298.1\|2176626_2178126_-\|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	cas8b4	cd09715_cas8b4_CAS-I-B	gnl\|CDD\|132526
NZ_CP025931.1\|WP_013815297.1\|2175599_2176616_-\|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	cas7b	cd09717_cas7b_CAS-I-B	gnl\|CDD\|132528
NZ_CP025931.1\|WP_013815289.1\|2162898_2163636_+\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|376822
NZ_CP025931.1\|WP_005874941.1\|2157659_2158652_-\|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP025931.1\|WP_013815284.1\|2155395_2156112_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_CP025931.1\|WP_013815299.1\|2178122_2178866_-\|type-I-PGING-CRISPR-associated-protein-Cas5p	cas5	cd09716_cas5_CAS-I-B	gnl\|CDD\|132527
NZ_CP025931.1\|WP_005874861.1\|2172774_2173287_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP025931.1\|WP_013815296.1\|2173306_2175610_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|273707
NZ_CP025931.1\|WP_148271466.1\|2179550_2179844_-\|DUF1661-domain-containing-protein	unknown	unknown	gnl\|CDD\|285160
NZ_CP025931.1\|WP_013815302.1\|2180174_2182106_-\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|293739
NZ_CP025931.1\|WP_005874853.1\|2171761_2172778_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_CP025931.1\|WP_010956469.1\|2153366_2153993_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP025931.1\|WP_010956473.1\|2171498_2171762_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856

Protein	Function_ID	Function_description	E-value
NZ_CP025931.1\|WP_004583651.1\|2153982_2155380_-\|signal-peptidase-I	gnl\|CDD\|182787	PRK10861, PRK10861, signal peptidase I.	8.0144e-17
NZ_CP025931.1\|WP_013815290.1\|2163708_2165457_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP025931.1\|WP_013815291.1\|2165715_2166801_-\|IS5-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.68725e-23
NZ_CP025931.1\|WP_013815300.1\|2178862_2179528_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.51138e-36
NZ_CP025931.1\|WP_013815288.1\|2159827_2162329_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.15123e-42
NZ_CP025931.1\|WP_013815299.1\|2178122_2178866_-\|type-I-PGING-CRISPR-associated-protein-Cas5p	gnl\|CDD\|132527	TIGR03488, cas_Cas5p, CRISPR-associated protein Cas5, subtype PGING. CC Members of this protein family are cas, or CRISPR-associated, proteins. The two sequences in the alignment seed are found within cas gene clusters that are adjacent to CRISPR DNA repeats in two members of the order Bacteroidales, Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This cas protein family is unique to the Pgingi (Porphyromonas gingivalis) subtype, but shows some sequence similarity to genes of the Cas5 type (see TIGR02593).	4.70758e-157
NZ_CP025931.1\|WP_013815285.1\|2156172_2157516_-\|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein	gnl\|CDD\|273571	TIGR01353, dGTP_triPase, deoxyguanosinetriphosphate triphosphohydrolase, putative. dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	5.94057e-159
NZ_CP025931.1\|WP_013815298.1\|2176626_2178126_-\|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	gnl\|CDD\|132526	TIGR03487, cas_csp2, CRISPR-associated protein Cas8c/Csp2, subtype PGING. Members of this protein family are cas, or CRISPR-associated, proteins. The two sequences in the alignment seed are found within cas gene clusters that are adjacent to CRISPR DNA repeats in two members of the order Bacteroidales, Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This cas protein family is unique to the Pging (Porphyromonas gingivalis) subtype.	0
NZ_CP025931.1\|WP_013815297.1\|2175599_2176616_-\|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	gnl\|CDD\|132528	TIGR03489, cas_csp1, CRISPR-associated protein Cas7/Csp1, subtype PGING. Members of this protein family are Csp1, a CRISPR-associated (cas) gene marker for the Pging subtype of CRISPR/cas system, as found in Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This protein belongs to the family of DevR (TIGR01875), a regulator of development in Myxococcus xanthus located in a cas gene region. A different branch of the DevR family, Cst2 (TIGR02585), is a marker for the Tneap subtype of CRISPR/cas system.	0
NZ_CP025931.1\|WP_013815289.1\|2162898_2163636_+\|DNA-repair-protein-RecO	gnl\|CDD\|376822	pfam02565, RecO_C, Recombination protein O C terminal. Recombination protein O (RecO) is involved in DNA repair and pfam00470 pathway recombination.	3.22277e-19
NZ_CP025931.1\|WP_005874941.1\|2157659_2158652_-\|putative-sulfate-exporter-family-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	6.63986e-54
NZ_CP025931.1\|WP_013815284.1\|2155395_2156112_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.17269e-51
NZ_CP025931.1\|WP_005874861.1\|2172774_2173287_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.76681e-68
NZ_CP025931.1\|WP_013815296.1\|2173306_2175610_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	2.55385e-158
NZ_CP025931.1\|WP_148271466.1\|2179550_2179844_-\|DUF1661-domain-containing-protein	gnl\|CDD\|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	3.34282e-06
NZ_CP025931.1\|WP_013815302.1\|2180174_2182106_-\|LTA-synthase-family-protein	gnl\|CDD\|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	2.83552e-65
NZ_CP025931.1\|WP_005874853.1\|2171761_2172778_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	8.51691e-165
NZ_CP025931.1\|WP_010956469.1\|2153366_2153993_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	3.40429e-12
NZ_CP025931.1\|WP_010956473.1\|2171498_2171762_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.04042e-30

>NZ_CP025931.1|WP_013815291.1|2165715_2166801_-|IS5-family-transposase
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVDTLNDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLLETWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGSITIEVADDREDNRSEEEKEAEEDYQKQVVRRRKGTDEEARWVYKQKRYHYGYKKHCPANVQGIVQKVITTAANRSDTKEFIPLLEGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQGNKAISPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSLR
>NZ_CP025931.1|WP_013815290.1|2163708_2165457_+|phospho-sugar-mutase
METDKLLDQVRAKARIWLGTEYDDSTRKAVQAMLDNADTTELVDAFYRDLEFGTGGLRGIMGAGTNRMNRYTVGAATQGLSNYLLRVFAGSSDISVVIGYDCRNNSRFFADTAAAVFSANGIGVYLFEELRPTPEISYAIRHLGCKSGVMITASHNPKEYNGYKAYWEDGAQIIAPHDRNIIAEVNRIRSVDEIKFEAKPELIRMIGENIDSAFIAEVKALSLSPESIARHRDMKIVYTPIHGTGSTVVPRALREYGFANIIHVPEQDVVSGDFPTVHSPNPEEPAALAMAIAKAEETSADLVLASDPDADRIGVAVRNNEGRMVLINGNEICSLLIYYSIMRRKELGDLHPDDYIVKTIVTTELIRDIAKKEHVSMFDCYTGFKWIAAVIRENEGRRRYIGGGEESYGFLWEDFIRDKSSVSACALFCEMAAWALDRGMSVYRLIRSIYLEYGLYYEKGLSVVRKGKSGAEEIEAMMRNYREYAPVELGGSPVQEILDYASLEGKDFTRGEKFSLDMPTTSNVLQYKTEDGTKVSIRPSGTEPKIKFYIGVHFSVANEQELDRAYIVAEEKIATILHDLGV
>NZ_CP025931.1|WP_013815289.1|2162898_2163636_+|DNA-repair-protein-RecO
MIIVSRAIVLHNTAYNDSYSIAHLFSRESGRVSYLIPRSSKRGKSGGSLRLLISPLNELEITAEHKQHRDLHFIKEAKLCSLHGRIQSDPVRNSIALFLAEFLYLILRLPEADTNLYDFVAFSIDKLEEMDGPMANFHLAFLFRLLVPLGLIPDLQFGGSVIPHWFDPADGRFVPNAPAHGRGIPPHQSTYLQLFSRITFDNMKAFRLSRAERRQVLDYLVDYYRFHLPPFPLLKTPDILSTLFD
>NZ_CP025931.1|WP_013815288.1|2159827_2162329_+|TonB-dependent-receptor
MKQLNIISFIIAFLFLGTSASAQQSGGSVTGTVVDKSSKEPIAYVQVFVKGTTLGTSTDANGNYSIKGIPSGNQTIVARLMGYSTCEEKVHIEKGGSRHVDLYLTEEILSLDGVVVSANRNETFRRQAPSLVTVLSPELFLKTNSTNLSQGLKFQPGLRVEDNCQNCGFNQVRINGLEGAYSQILIDSHPIFSSLAGVYGLEQMPANMIERVEVIRGGGSALFGSNAVGGVINVITKEPLRNSAEISHSTMTFDHAKGWGSFQNTTQFNGSMLTEDRKAGVMVFGQHNYRPGQDIDGDSFTELPNLRNRSLGFRSYYKTGLYSKATLEYHSMQEYRRGGDRLDNPPFEAQIAEYLQHYINGGSFKFDQGFSGGKDFFSLYASAQDVQRRSYYGGGDYTENLLNGAVQSGSTESDEYNNAFTALTSYGTTKGFDLQGGGMYRHTFGENWDFTGGLEYIYGQLDDRSGYRPSKIDQNTSTFSQYDQLEYKTEKLSALIGARIDYVLLNQDGKRYIDPLFIFSPRANVRYNPNKNLSFRLSYSEGFRAPQYFDEDLHVELAGGTPISRVLSPNLKEERSRSISASFDYYHRADEWQFNIMGEAFSTFISNQFKPSDKVETTSDGKEWIIRTIYNDKDGVSKVYGVNLEGRIAYNKSFDLQLGGTWQRSRYGSIYTAVEADKTTGQAEISVKDYVRTPNLYGYFVATVRPTEHFAINLSGTFTGKMDVVHEAYEGDIPAEHIAPDGSFDFEMNGQQFKGLAEGHAKLVKTPAFADIDLKLSHDFHLASTMTLELNAGIQNIFNSYQKDTDKGPGRASTYVYGPMQPRRIFVGTKINF
>NZ_CP025931.1|WP_005874903.1|2159161_2159521_+|hypothetical-protein
MKERLNQTVRYFLPILFAVYAGLVISFTHVHIINGVIIVHSHVQWGDNESDPQDNPHSDSELILYNQLSAIFTTYLDTPAIDLKEPVRVVGVVPFFCDNLTALISELTPSNHLRAPPVA
>NZ_CP025931.1|WP_005874941.1|2157659_2158652_-|putative-sulfate-exporter-family-transporter
MNTDNPKSHISRIAYPAIIVFLILTLLGSLVERFHPFTSWLTPPVALLMGLAYALIFGSTHRRANKLGSKVLLQYSVVGLGFGMNLGESLASGRDGMMFTIISVFGTLLLGWFIGRKILQMNRNTSALISAGTAICGGSAIAAVGPILKAEEHEMSVALGTVFLLNAVALFIFPSIGHWLALDQQQFGTWAAIAIHDTSSVVGAGSAYGEEALRVATTIKLTRALWIVPLTLVFSFVYKTKGAKRFPVPLFILFFIGAIILNTYLLEAYFPEVGRFVASLARKGLTLSLFFIGASLTKEVIASVGVRALLQGLFLWILISVGSLAFILLI
>NZ_CP025931.1|WP_013815285.1|2156172_2157516_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein
MTMMQWERLLSDKRVGMEHYHQPKQSAQPWERTDFERDYDRMVFSSPFRRLQNKAQVFPLAGNIFVHNRLTHSLEVSCVGRSLGNNITRGLKARYGELPWESGAISAIVSAACLAHDMGNPPFGHSGERAISAYFREGKGRVWEDAVRKEGGRWEDFLHFEGNANAFRLLTHQFEGRRKGGFALTYSTVASIVKYPYSSEMAGKAGKFGFFATEEDTFLMIAEELGMLCRNEHPVKYARYPLVYLVEAADDICYQIMDIEDAYKLRILTYAETENLFLAFCPEEELRHIRGVLDHITDANEQIAYLRSRVISLLVESCTRVFLDHEDEILSGTFSGTLIGAMEPRLKEAYGACARMAYSKIYVARDVVDVELAGHQIFGALIDKMMQALTNPDHAYSRTLLSRVSTQYNIREESLYGKIQCTLDYISGMTDIYALDLYRKITGMNLR
>NZ_CP025931.1|WP_013815284.1|2155395_2156112_-|4-hydroxy-tetrahydrodipicolinate-reductase
MKIVLIGYGKMGHVIERIACSRGHEVVLTIDAGEEDRFDSIAFRSADVAIEFTRPDAAYANCSRCMDKSVPVVCGTTGWTERLPVLEERCRREGKTLFWASNFSIGVNLFFSLGRMFARLMSRHDQYRPHLTEIHHVHKLDAPSGTAITLAEGLIAESPSLDAWRLTETPEENELPITSIREGEVPGTHSISYTSEVDRLTICHEAFGREGFALGAVLAAEYAATHKGFLTMNDLISL
>NZ_CP025931.1|WP_004583651.1|2153982_2155380_-|signal-peptidase-I
MTFHWKDLTPWRRIKGVAITILYLLFCIWAGPFWLIFLPLIVDYYFFHIIKWGWYKNIRNKTLRIICSWVADIIYCVVAVTFIFAFLFQNFAIPTSSLEKTLLIGDYLFVSKLSYGPRSPMTPLGVPLTHNTMPLTGGKSFSDKPLLPYKRLKGFGHVKEGDLVVFNFPAGDTVAVKQPNPDYYMWKKLVGREELWSNPDFYGEIVYRPVDRRDHYVKRCVGMPGQELSIRNNQIYIDGKEQRNPRNMQLNYLVRMSREMSVDLIDELGISYDDVRAASSEELKASVGSNLIDSASNQPQIIYHLPLTQGMLDKLQAEPSFVKAVEEPTPIGPLYPLEYETGWTRDNYGPIVIPAKGMTVRLTPLNLALYSRCIRNFEGNKLVQKADGTVLINGRTADSYTFKMDYYFMMGDNRHNSADSRYWGFVPEDHIVGKPVFIWLSLNKDKSLFGGKIRFGRMMRTVNAD
>NZ_CP025931.1|WP_010956469.1|2153366_2153993_-|signal-peptidase-I
MQIKSRYRNRIFFIGLPAVVLLSAVLIRLFLVTTYRVRSDAMLPTYRSGKLLWINRIASPDRGDILVIKYRQDGEADSRFYLARLIGLPGDTLFLSKGGVVANRQKLKLPTSLLPREPYKIIVPRNDRTYRLTPLSLLAYRRAIEEECSSNISFRRGKLYRDGAETAFFHFRRNYYWILADNPASGPDSRHLGIVPEESIVGVVMNAN
>NZ_CP025931.1|WP_010956473.1|2171498_2171762_-|CRISPR-associated-endonuclease-Cas2
MYIILVYDIGEKRVGKMLKLCRKYLNWIQNSVFEGEISEVKLLELKSRAAGIMEKEEDSLIIFSSRQERWLEKEIIGKERSATDIFL
>NZ_CP025931.1|WP_005874853.1|2171761_2172778_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTYYLFNPGELSRKDNTIRFVPIQEGENGQEQAGQARYIPVEGISDFYVFGSLRANSSLYNFLGSNDIAVHFFDYYENYTGSFMPRDFLLSGKMLLAQASAYKNKKKRLFLARKFIEGAASNMQKNLAYYNNRGKDMQPMMELIDKYSLRLKETTTIEALMGIEGNIRQAYYDAFNLIIDPFEMGVRSKQPPQNEVNALISFGNMMCYTLCLKAIHQSQLNPTISFLHTPGERRYSLCLDISEVFKPILVDRTIFKVMNKRIIQAKHFDKQLNKCILNPSGKKLFVQAFEERLSETIRHRKLNRSVSFRHLVKLECYKIAKDILGIEEYQPFKMYW
>NZ_CP025931.1|WP_005874861.1|2172774_2173287_-|CRISPR-associated-protein-Cas4
MNTISGTHFNYHQVCRRKLWLFSAGITMEHTSDLVYEGKLIHETTYQQRPERYQELELDGIKIDFYDAKNRVVHEVKKSNKISPAHRLQLLYYLYVLERNGVLGATGILEYPTLRKKEEVILSDIDRERIREIEQEILQIISHEDCPPVIDSGICKNCSYYEFCFSGEEQ
>NZ_CP025931.1|WP_013815296.1|2173306_2175610_-|CRISPR-associated-helicase/endonuclease-Cas3
MINKESPILAKPSGITLDVHAENVIQEGALLLKGLGCTKEKYFQTTAKQIVQRVELACKYHDIGKRNKIWQDACKKDYKAYLIWKKIHPNKSFEDYTIECREEAGKFLRQTHVRHEFYSIKGLLNNNPPPWLKIAIAAHHRKLSMKHEERWLSSDEDICSVWKDIRRLSNCFFDDRNSVLSDIVIKQYEFAGPRSLLQLADHRASAKEESKDIPDPIAFSYTFPEKWEKRPVQKLVEKHWRDELLLVRAPTGAGKTDAALLWASLQIKHRKADRLIIAMPTRFTTNALALNVSSTLSSTGLYHSSAWTQNFSSKIDNGEIALEQARYYHNQARLLQTPITVCTIDHLLSSLTLCDEEHQTITFALANACLVIDEADFYDQFTQANILVLLEVLKYWKVPILLMSASLPDNIVQEYRKIGYDIKHILEDTSDIERARFSLIEKRDVSEISQMQDLLQLCLDRGSAIIFANTVDRAQAYYQWFLENGHEEEVILYHSRYTETDKIEKEAQLLLRLGRSAWDNDRANGVAILTQIGEMSVNISADIMISDLCPIDRLTQRCGRLCRFSRKIGDLYIIRPMREGNLFPAPYYQNVGPSQKLEPNDALIKTDELLEKGMYSAANLVQLLNKVYANQTVFSTEASCNADRLREMFKANWLINPIEYLDEEIGSTNFWRARNIMPRCRIYIKRPLQSFRNYSDFRRWETDVAIDIPIYVIKKAMRMSDTVCSQVKVCIGKNDYTLIVINAKCYNNVRGLFFSKSVLEEPNFEFL
>NZ_CP025931.1|WP_013815297.1|2175599_2176616_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1
METKKIAGVLVTMVAPFENHMANGGEKLFGNASSIKRRPDGRVYVSGQMQRHVLFSAIDRLNHLDKAKGTTFVSNGDGITNLIEIDLRADLGGFMHTNKGDYSDRRIAPLSVTPATALDTSSVGRDLLVRIRFDKSSDAKNQALATREYSEQDKMNMNFFLDITSVGVSKSFVYKDGLNLGTKYFKHITDDEKKRRVKLFLEATRIMNDYANQARNAVCGEPEKVLIVFDDRLSRKACRYYTAGEKEQANIIKELNECQVKYFIGDDTSDYSVADAYRDAINYLDKATFVDLAEGEEIMTFAEAFECKEKEPQGKKSKKGKDKATSAQNLFAEQQDDQ
>NZ_CP025931.1|WP_013815298.1|2176626_2178126_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2
MNTNHYYIRYGCAITLYDNHVSERERLTPKELRFSIEKAVSSFRIQAQEPFSPGSKARFSFVKRKDGNTKNGIFLSPHIVTKDMHAQKVWTKASKFLEIDYLGKDNEREGLLKKDNVSMSNIPISGEFLTFGEKDTGRGSAKISVEEQTYGLITTLTTLKPALQVGKDNFCIIPDIPLNQMVDFITLLDKMQITHLSGEAMLGNIDNKGIPHRPKIFRGNFPNSPKSDRMGAIALLGAIGEFAKHAEFSTLAQKVLDSLKGSTLYLITYANAIPFTFHHYIIDLAKEGKLHSIVDSLFYSRLYKKEKRVYGDTDYDRFDFFANRFLQSFNKAAFDDFFSSRVEYPNQIKILFQMFFTKMEKLKTDVIASAQVLGSWLNQVAYFAAKEEADSRISPGNIFEEKAKFLVMMESSIYAAKRGDALIAQILILAGRLSKNEAPKEALLFMEKTITGEIDLSVAKNLLIAYMRIRREEKQRDLNSVKNDDAIPSDINIDDLTNT
>NZ_CP025931.1|WP_013815299.1|2178122_2178866_-|type-I-PGING-CRISPR-associated-protein-Cas5p
MKYNMKNIDLSILGKDPDLSASIKLHIEPHAPISMVSELPGSYYKALLYPDKHILCGLFENVLGWHFSRKDREIITKEIKNIRKKAKKGYIPPTIRSIFIPLLSDFFELDSVRIVSTDSPFFYNDLWKRAFRRKDAGKIHFGGTQNIDYTLVMDKFRFMCENERALETEEKTDQKEEKFLRENIDRISFFYTTPTNREYLFFEGNYECVIKMDPQLVDLLSKTLPQQNMGYLGNSEGWVTLYLEEKS
>NZ_CP025931.1|WP_013815300.1|2178862_2179528_-|CRISPR-associated-endoribonuclease-Cas6
MRIELSIKADDSLVSFSHQHLLVGTLQKWLGENDMHGKSISYSFSRLNGGKLVSELNSILFADWANMFVSAHDPELIRRMLAGIRQDPEMFKSLCVREVTVIEDPDMTDREIFFPASPILLKRWREDNGFDHIVYTDEAANALLTENLRKKLQAVGIDDPTATASFVPDKGKAKVMLIDYRGVKNKASWCPIRIIGNAETKLFAWNAGIGNSTGIGFGAIK
>NZ_CP025931.1|WP_148271466.1|2179550_2179844_-|DUF1661-domain-containing-protein
MCLRPRKTWRVNFFVLVREIKNSRATTKNFLFRFFRKHAPQSEHFRFVFYTPPSPLFYFQCGFRKIPRNDGCYISDFLANKHKKYALITAFRVTLGH
>NZ_CP025931.1|WP_013815302.1|2180174_2182106_-|LTA-synthase-family-protein
MKTLFERGELLFRKRSGFCYVIGVFVLFLLYFLFQKVIFLLVYSGQLAGIGTSSGDIAAIFLHGLRHDAAVAAYLTVLPLLFAGINAIAGWGEKKIGRIQRQILKHYYTLISFFVGLIYTADLMLFGYWGFRLDATPLFYLRQPQEAMASATTPQLLISLLITVVFVCIPAFVLHRFHRRYFPTKVAAHPHIAGIWKPVVGGAFLFLLIRGGVGVATLNVGSVFHSPKQLHNQAAVNPVFSFLYTCMHSEEDYSNYQFLSEEDCIKAFEQLRLYGCSDGSEVRESASDSTERILSTDRPNIVLILLESFSANAVGCLGGTPGHTPCIDSLAQNGILFSQAFASSFRTDRGTVATLSGYPSQPNSSIIKYPNKVRNLPGIAASLRTVGYSTHHLYGGDADFTNVRSYLYATGYDEVTDVSSFPIKTRLSKWGTPDHISFPRLLDDCRRLEKEKKPYFYSFLTLSSHEPFDVPSQHHPDPYLNSVFYTDSCFGDYIRGMQQSPQWKNTLIITVSDHGYPYPADQAMPDQPGRYGIVMLWTGGAISRPIRFEEVVSQSDLPATLLAQLGLAHDEFVFSKDVFRRNSPHFAYFSFPGLVGLATSEGTTIYDFAGDKIVYGYEAPLADQRAIAAKVMLQSVMKDMLSR

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP025931_2	2.1\|114710\|30\|NZ_CP025931\|PILER-CR,CRISPRCasFinder,CRT	114710-114739	30	NZ_CP025931.1	819979-820008	1.0
NZ_CP025931_5	5.1\|2110847\|38\|NZ_CP025931\|CRISPRCasFinder	2110847-2110884	38	NZ_CP025931.1	1568606-1568643	1.0
NZ_CP025931_7	7.3\|2133158\|41\|NZ_CP025931\|PILER-CR,CRISPRCasFinder,CRT	2133158-2133198	41	NZ_CP025931.1	63698-63738	1.0
NZ_CP025931_8	8.1\|2166972\|36\|NZ_CP025931\|CRISPRCasFinder,CRT	2166972-2167007	36	NZ_CP025931.1	2166906-2166941	1.0
NZ_CP025931_8	8.2\|2167038\|36\|NZ_CP025931\|CRISPRCasFinder,CRT	2167038-2167073	36	NZ_CP025931.1	2166906-2166941	1.0
NZ_CP025931_8	8.3\|2167104\|36\|NZ_CP025931\|CRISPRCasFinder,CRT	2167104-2167139	36	NZ_CP025931.1	2166906-2166941	1.0
NZ_CP025931_8	8.4\|2167170\|36\|NZ_CP025931\|CRISPRCasFinder,CRT	2167170-2167205	36	NZ_CP025931.1	2166906-2166941	1.0

1. spacer 2.1|114710|30|NZ_CP025931|PILER-CR,CRISPRCasFinder,CRT matches to position: 819979-820008, mismatch: 0, identity: 1.0

gatgtggctgtagatgcactcttccgcaaa	CRISPR spacer
gatgtggctgtagatgcactcttccgcaaa	Protospacer
******************************

2. spacer 5.1|2110847|38|NZ_CP025931|CRISPRCasFinder matches to position: 1568606-1568643, mismatch: 0, identity: 1.0

attactacgggaaagcccagcgaacgcattgccggaat	CRISPR spacer
attactacgggaaagcccagcgaacgcattgccggaat	Protospacer
**************************************

3. spacer 7.3|2133158|41|NZ_CP025931|PILER-CR,CRISPRCasFinder,CRT matches to position: 63698-63738, mismatch: 0, identity: 1.0

cgggagtgcgacaagatacttggctccggccgcacgattgg	CRISPR spacer
cgggagtgcgacaagatacttggctccggccgcacgattgg	Protospacer
*****************************************

4. spacer 8.1|2166972|36|NZ_CP025931|CRISPRCasFinder,CRT matches to position: 2166906-2166941, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

5. spacer 8.2|2167038|36|NZ_CP025931|CRISPRCasFinder,CRT matches to position: 2166906-2166941, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

6. spacer 8.3|2167104|36|NZ_CP025931|CRISPRCasFinder,CRT matches to position: 2166906-2166941, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

7. spacer 8.4|2167170|36|NZ_CP025931|CRISPRCasFinder,CRT matches to position: 2166906-2166941, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP025931_4	4.1\|1372056\|29\|NZ_CP025931\|CRISPRCasFinder	1372056-1372084	29	NZ_CP024656	Bacillus cereus strain MLY1 plasmid pMLY1.2, complete sequence	41975-42003	7	0.759
NZ_CP025931_8	8.13\|2167765\|34\|NZ_CP025931\|CRISPRCasFinder,CRT,PILER-CR	2167765-2167798	34	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	714094-714127	7	0.794
NZ_CP025931_8	8.13\|2167765\|34\|NZ_CP025931\|CRISPRCasFinder,CRT,PILER-CR	2167765-2167798	34	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	714110-714143	7	0.794
NZ_CP025931_8	8.13\|2167765\|34\|NZ_CP025931\|CRISPRCasFinder,CRT,PILER-CR	2167765-2167798	34	NC_029073	Geobacillus virus E3, complete genome	39503-39536	7	0.794
NZ_CP025931_2	2.2\|114776\|30\|NZ_CP025931\|PILER-CR,CRISPRCasFinder,CRT	114776-114805	30	MN694560	Marine virus AFVG_250M172, complete genome	19299-19328	8	0.733
NZ_CP025931_8	8.60\|2170859\|35\|NZ_CP025931\|CRISPRCasFinder,CRT,PILER-CR	2170859-2170893	35	NC_009806	Kineococcus radiotolerans SRS30216 = ATCC BAA-149 plasmid pKRAD01, complete sequence	92086-92120	9	0.743
NZ_CP025931_8	8.63\|2171056\|35\|NZ_CP025931\|CRISPRCasFinder,CRT,PILER-CR	2171056-2171090	35	NZ_CP007231	Yersinia similis strain Y_sim_228 plasmid unnamed, complete sequence	29435-29469	9	0.743
NZ_CP025931_8	8.63\|2171056\|35\|NZ_CP025931\|CRISPRCasFinder,CRT,PILER-CR	2171056-2171090	35	NC_011759	Yersinia pseudotuberculosis pGDT4 plasmid	20547-20581	9	0.743

1. spacer 4.1|1372056|29|NZ_CP025931|CRISPRCasFinder matches to NZ_CP024656 (Bacillus cereus strain MLY1 plasmid pMLY1.2, complete sequence) position: , mismatch: 7, identity: 0.759

ggcaaagatgaaagcaaatggagggaaga	CRISPR spacer
taaatatatgaaagcaaatggatggaagg	Protospacer
 . * * *************** *****.

2. spacer 8.13|2167765|34|NZ_CP025931|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 7, identity: 0.794

taaataatcatttaattgtaacattttgtgaata-	CRISPR spacer
aaaataatgatttaattgtaaaattatat-agtat	Protospacer
 ******* ************ *** *.* *.**

3. spacer 8.13|2167765|34|NZ_CP025931|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 7, identity: 0.794

taaataatcatttaattgtaacattttgtgaata-	CRISPR spacer
aaaataatgatttaattgtaaaattatat-agtat	Protospacer
 ******* ************ *** *.* *.**

4. spacer 8.13|2167765|34|NZ_CP025931|CRISPRCasFinder,CRT,PILER-CR matches to NC_029073 (Geobacillus virus E3, complete genome) position: , mismatch: 7, identity: 0.794

taaataatc--atttaattgtaacattttgtgaata	CRISPR spacer
--gattatctgctttaattgttacattttgtaaata	Protospacer
  .** ***   ********* *********.****

5. spacer 2.2|114776|30|NZ_CP025931|PILER-CR,CRISPRCasFinder,CRT matches to MN694560 (Marine virus AFVG_250M172, complete genome) position: , mismatch: 8, identity: 0.733

gaagtggccaatgttcgataggctgctcag	CRISPR spacer
gaactggccaatgtttgataggccatgacg	Protospacer
*** ***********.*******...   *

6. spacer 8.60|2170859|35|NZ_CP025931|CRISPRCasFinder,CRT,PILER-CR matches to NC_009806 (Kineococcus radiotolerans SRS30216 = ATCC BAA-149 plasmid pKRAD01, complete sequence) position: , mismatch: 9, identity: 0.743

cctccgcccccagcccgctatcgacccccacctgc	CRISPR spacer
ccctggatccccgcccgctgtcgacccccacctcg	Protospacer
**.. * .*** *******.*************

7. spacer 8.63|2171056|35|NZ_CP025931|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP007231 (Yersinia similis strain Y_sim_228 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.743

acttcgccgtccgcggtaatgtgaccaataccgac	CRISPR spacer
atatcgccgtacccggtaatgtgaccaacagtgtt	Protospacer
*. ******* * ***************.* .* .

8. spacer 8.63|2171056|35|NZ_CP025931|CRISPRCasFinder,CRT,PILER-CR matches to NC_011759 (Yersinia pseudotuberculosis pGDT4 plasmid) position: , mismatch: 9, identity: 0.743

acttcgccgtccgcggtaatgtgaccaataccgac	CRISPR spacer
atatcgccgtacccggtaatgtgaccaacaatgtt	Protospacer
*. ******* * ***************.* .* .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

683419 : 735664

Ralstonia_phage(33.33%)

protease,integrase,transposase

attL 699405:699420|attR 742555:742570

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013816551.1\|683419_684505_+\|transposase	IS5 family transposase	A0A077K814	Ralstonia_phage	9.9e-20	28.1
WP_043890209.1\|685841_687854_+	AAA family ATPase	NA	NA	NA	NA
WP_013816555.1\|687847_688435_+	hypothetical protein	NA	NA	NA	NA
WP_013816556.1\|688441_689560_+	hypothetical protein	NA	NA	NA	NA
WP_013816557.1\|689572_690865_+	methyltransferase	NA	NA	NA	NA
WP_013816559.1\|691366_692446_+\|transposase	IS5 family transposase	A0A077K814	Ralstonia_phage	1.0e-16	26.5
WP_013816560.1\|692606_693071_+	DUF3872 domain-containing protein	NA	NA	NA	NA
WP_013816561.1\|693101_693749_-	hypothetical protein	NA	NA	NA	NA
WP_013816562.1\|693783_694251_-	PH domain-containing protein	A0A2H5BNL9	Klebsiella_phage	5.8e-09	31.1
WP_043890121.1\|694355_695708_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_013816564.1\|695821_696334_-	hypothetical protein	NA	NA	NA	NA
WP_013816565.1\|696374_696989_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013816566.1\|697003_697576_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_013816567.1\|697572_698217_-	hypothetical protein	NA	NA	NA	NA
WP_013816569.1\|698828_699110_-	hypothetical protein	NA	NA	NA	NA
WP_005874553.1\|699132_699360_-	hypothetical protein	NA	NA	NA	NA
WP_013816570.1\|699372_699894_-	hypothetical protein	NA	NA	NA	NA
699405:699420	attL	NA	NA	NA	NA
WP_021661933.1\|699900_700260_-	hypothetical protein	NA	NA	NA	NA
WP_013816573.1\|700617_701076_-	DUF1896 domain-containing protein	NA	NA	NA	NA
WP_012457820.1\|701102_701636_-	ORF6N domain-containing protein	NA	NA	NA	NA
WP_013816574.1\|701671_702904_-\|integrase	site-specific integrase	H7BUI8	unidentified_phage	4.4e-32	38.1
WP_004585423.1\|703516_704185_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_013816575.1\|704181_704376_-	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_013816576.1\|704764_706573_+	tetratricopeptide repeat-containing sensor histidine kinase	NA	NA	NA	NA
WP_004585426.1\|706585_707269_+	response regulator transcription factor	NA	NA	NA	NA
WP_004585427.1\|707454_708141_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_013816577.1\|708232_708718_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	9.9e-28	42.9
WP_013816578.1\|708858_711390_+	T9SS type A sorting domain-containing protein	NA	NA	NA	NA
WP_013816581.1\|712515_714186_+	peptidylarginine deiminase PPAD	NA	NA	NA	NA
WP_013816582.1\|714410_715943_+	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_010956309.1\|716278_716449_+	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_013816583.1\|716885_718694_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	6.1e-46	39.1
WP_013816584.1\|718816_720463_-	fumarate hydratase	NA	NA	NA	NA
WP_077070601.1\|720531_720762_-	cysteine-rich CWC family protein	NA	NA	NA	NA
WP_013816585.1\|720758_721700_-	2-nitropropane dioxygenase	NA	NA	NA	NA
WP_013816586.1\|722132_724736_-	TonB-dependent receptor plug domain-containing protein	NA	NA	NA	NA
WP_021664251.1\|726642_728328_+	putative transporter	NA	NA	NA	NA
WP_043894868.1\|728543_728936_+	hypothetical protein	NA	NA	NA	NA
WP_005873381.1\|728932_729898_-	cation transporter	NA	NA	NA	NA
WP_043890212.1\|730160_730697_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_043890124.1\|731161_734017_+	LPS-assembly protein LptD	NA	NA	NA	NA
WP_013816596.1\|734043_734766_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_013816597.1\|734749_735664_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
742555:742570	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP025931.1|WP_004584358.1|1086440_1086854_+|PcfK-like-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP025931.1|WP_004584358.1|1086440_1086854_+|PcfK-like-protein

1086440_1086854_+

137 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|40	0.5815602836879432	1	1.0

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP025931

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information