CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP027129	Escherichia coli strain AR_0372 plasmid unnamed5	0 crisprs	NA	0	1
NZ_CP027130	Escherichia coli strain AR_0372 plasmid unnamed1, complete sequence	0 crisprs	csa3	0	1
NZ_CP027131	Escherichia coli strain AR_0372 plasmid unnamed3, complete sequence	0 crisprs	NA	0	0
NZ_CP027133	Escherichia coli strain AR_0372 plasmid unnamed4	0 crisprs	cas14j	0	1
NZ_CP027134	Escherichia coli strain AR_0372 chromosome, complete genome	3 crisprs	DEDDh,c2c9_V-U4,DinG,cas3,csa3,cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,PD-DExK	14	11
NZ_CP027132	Escherichia coli strain AR_0372 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

737 : 91688

Escherichia_phage(63.22%)

integrase,transposase,head,tail

attL 12276:12292|attR 61176:61192

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_086352859.1\|737_3725_+	hypothetical protein	A0A1B0VFX4	Salmonella_phage	0.0e+00	98.9
WP_001165937.1\|3714_4023_+	hypothetical protein	Q1MVN0	Enterobacteria_phage	2.4e-48	94.1
WP_099368671.1\|4226_4598_+	hypothetical protein	NA	NA	NA	NA
WP_000148486.1\|4805_6161_-	deoxyguanosinetriphosphate triphosphohydrolase family protein	NA	NA	NA	NA
WP_000068872.1\|6409_6898_-	single-stranded DNA-binding protein	A0A1B0VAF5	Salmonella_phage	1.3e-64	79.0
WP_001345478.1\|7067_7625_+	lysozyme	Q71TF3	Escherichia_phage	4.2e-107	100.0
WP_024187336.1\|7617_7866_+	hypothetical protein	Q71TF4	Escherichia_phage	1.0e-36	100.0
WP_000526135.1\|8048_8507_+\|transposase	IS200/IS605 family transposase	I4AZI8	Saccharomonospora_phage	2.9e-13	32.3
WP_000132937.1\|8621_9641_-\|head	head processing protein	Q71TR6	Escherichia_phage	4.4e-179	96.8
WP_001312284.1\|9753_10884_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	Q9G0F2	Phage_Gifsy-1	9.2e-186	84.5
WP_025210446.1\|10916_12638_-	hypothetical protein	Q1MVN6	Enterobacteria_phage	0.0e+00	99.5
12276:12292	attL	NA	NA	NA	NA
WP_060578233.1\|12713_19481_+	N-6 DNA methylase	Q1MVN7	Enterobacteria_phage	0.0e+00	98.8
WP_000224043.1\|19514_19955_+	hypothetical protein	A0A077SLF0	Escherichia_phage	1.7e-79	100.0
WP_000747846.1\|19951_20200_+	hypothetical protein	Q71TG0	Escherichia_phage	1.8e-41	100.0
WP_000526244.1\|20236_21364_-	RelA/SpoT domain-containing protein	A0A1B0VBT5	Salmonella_phage	7.6e-156	74.1
WP_023351534.1\|21466_22108_-	hypothetical protein	A0A077SK30	Escherichia_phage	1.2e-110	96.7
WP_023356281.1\|22297_22858_-	Ref family protein	Q5QBN4	Enterobacteria_phage	1.5e-99	98.9
WP_001224234.1\|23104_23416_-	hypothetical protein	A0A077SK03	Escherichia_phage	1.0e-46	100.0
WP_000067530.1\|23466_24498_-\|integrase	tyrosine-type recombinase/integrase	Q71TG5	Escherichia_phage	9.9e-195	100.0
WP_000542336.1\|24505_24727_-	hypothetical protein	Q5QBN7	Enterobacteria_phage	4.5e-36	100.0
WP_000874156.1\|25323_25533_+	hypothetical protein	A0A077SK26	Escherichia_phage	1.8e-31	100.0
WP_000611664.1\|25643_26495_+	hypothetical protein	A0A077SLM8	Escherichia_phage	1.2e-158	100.0
WP_032246984.1\|26527_27646_-	antirepressor	A0A077SLR9	Escherichia_phage	3.7e-179	88.7
WP_071528000.1\|27642_28002_-	host cell division inhibitor Icd-like protein	Q38557	Escherichia_phage	2.6e-25	80.3
WP_000124159.1\|28203_29688_-	hypothetical protein	Q5QBP2	Enterobacteria_phage	4.3e-292	99.8
WP_060578234.1\|29687_30881_-	hypothetical protein	A0A077SL59	Escherichia_phage	9.8e-178	99.0
WP_001326849.1\|30966_31419_-	late promoter-activating protein	Q71T63	Escherichia_phage	3.0e-79	100.0
WP_029393260.1\|31507_32551_-	DUF968 domain-containing protein	A0A077SLM1	Escherichia_phage	1.7e-205	99.4
WP_000113018.1\|32578_32758_-	hypothetical protein	Q71TH5	Escherichia_phage	1.2e-23	98.3
WP_001216045.1\|32762_33143_-	type II toxin-antitoxin system death-on-curing family toxin	Q71T66	Escherichia_phage	1.9e-63	100.0
WP_001190712.1\|33142_33364_-	type II toxin-antitoxin system Phd/YefM family antitoxin	A0A222YXU1	Escherichia_phage	6.7e-32	100.0
WP_060578235.1\|33546_35103_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.4e-104	42.9
WP_072196859.1\|35099_36356_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_072650946.1\|36477_39594_+	HsdR family type I site-specific deoxyribonuclease	A0A220A398	Liberibacter_phage	8.3e-27	24.0
WP_060578216.1\|39859_40366_-	hypothetical protein	A0A1B0VAK0	Salmonella_phage	1.2e-92	98.8
WP_001774489.1\|40438_41701_-	hypothetical protein	Q1MVG4	Enterobacteria_phage	2.7e-234	99.8
WP_032162337.1\|42002_42704_-	hypothetical protein	Q1MVG6	Enterobacteria_phage	1.3e-142	99.6
WP_001354545.1\|42700_43378_-	calcineurin phosphoesterase	A0A077SLQ6	Escherichia_phage	7.6e-135	100.0
WP_000484107.1\|43374_44001_-	hypothetical protein	A0A077SK52	Escherichia_phage	2.3e-122	99.5
WP_012817939.1\|43898_44561_-	hypothetical protein	Q71T83	Escherichia_phage	4.5e-124	100.0
WP_000095380.1\|44502_44658_-	hypothetical protein	A0A077SK20	Escherichia_phage	1.2e-19	100.0
WP_060578240.1\|44724_45303_-	VRR-NUC domain-containing protein	A0A077SLK0	Escherichia_phage	2.0e-104	96.9
WP_000840930.1\|45305_45551_-	hypothetical protein	A0A1B0VDU5	Salmonella_phage	1.5e-40	100.0
WP_000235786.1\|45697_46075_+	hypothetical protein	Q38620	Escherichia_phage	2.2e-67	100.0
WP_001141901.1\|46084_47302_+	hypothetical protein	A0A077SL53	Escherichia_phage	1.9e-224	99.8
WP_000896801.1\|47305_48034_+	hypothetical protein	A0A077SK19	Escherichia_phage	9.3e-139	100.0
WP_060578241.1\|48020_48806_+	hypothetical protein	A0A1B0V7N6	Salmonella_phage	7.9e-144	99.2
WP_000212025.1\|48807_49824_+	hypothetical protein	Q1MVH7	Enterobacteria_phage	3.5e-192	100.0
WP_000535203.1\|49816_50449_+	hypothetical protein	A0A077SK50	Escherichia_phage	6.9e-90	100.0
WP_060578242.1\|50495_51494_-	hypothetical protein	A0A1B0VCH7	Salmonella_phage	3.4e-192	97.6
WP_001276599.1\|51493_52858_-	replicative DNA helicase	A0A077SK18	Escherichia_phage	2.1e-253	100.0
WP_000234831.1\|53330_53495_-	DUF3927 family protein	Q71T96	Escherichia_phage	7.6e-17	100.0
WP_000900640.1\|53494_53920_-	tellurite/colicin resistance protein	Q71TK7	Escherichia_phage	1.8e-70	100.0
WP_000660972.1\|55477_57742_-	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A077SL51	Escherichia_phage	0.0e+00	68.5
WP_000472529.1\|57738_58644_-	recombination-associated protein RdgC	A0A077SK17	Escherichia_phage	1.6e-159	99.7
WP_001177860.1\|58636_58921_-	hypothetical protein	Q71TA2	Escherichia_phage	3.5e-49	100.0
WP_001569402.1\|59383_60172_+	hypothetical protein	Q71TL4	Escherichia_phage	1.0e-119	100.0
WP_000007765.1\|60211_60634_+	hypothetical protein	Q71TL5	Escherichia_phage	5.0e-60	100.0
WP_000336812.1\|60659_60800_+	hypothetical protein	Q71TL6	Escherichia_phage	6.3e-20	100.0
WP_001281115.1\|60809_61202_+	hypothetical protein	A0A077SLJ1	Escherichia_phage	7.6e-71	97.7
61176:61192	attR	NA	NA	NA	NA
WP_001113742.1\|61537_62422_+	RepB family plasmid replication initiator protein	A0A077SLP3	Escherichia_phage	2.1e-161	100.0
WP_001154687.1\|62714_63524_+	GIY-YIG nuclease family protein	A0A077SK46	Escherichia_phage	7.1e-156	97.8
WP_001285362.1\|63692_64889_+	ParA family protein	A0A077SL49	Escherichia_phage	1.6e-225	100.0
WP_000038866.1\|64905_65907_+	ParB/RepB/Spo0J family partition protein	Q38420	Escherichia_phage	1.7e-178	100.0
WP_023153705.1\|66133_67840_+	hypothetical protein	Q1MVJ5	Enterobacteria_phage	4.7e-311	94.4
WP_000085137.1\|67900_69490_+	hypothetical protein	Q71TB2	Escherichia_phage	2.9e-302	98.9
WP_000041757.1\|69499_70315_+	hypothetical protein	A0A1B0V835	Salmonella_phage	2.6e-113	99.3
WP_000035302.1\|70350_70932_+	hypothetical protein	A0A077SL48	Escherichia_phage	4.5e-104	100.0
WP_000509939.1\|70943_71453_+	hypothetical protein	Q1MVJ9	Enterobacteria_phage	1.3e-91	100.0
WP_000268409.1\|71624_72221_+	hypothetical protein	A0A077SLI4	Escherichia_phage	5.3e-108	99.5
WP_001426344.1\|72403_72649_-	hypothetical protein	A0A1B0VDM5	Salmonella_phage	3.5e-13	45.0
WP_024188253.1\|72699_73545_-	hypothetical protein	Q1MVK3	Enterobacteria_phage	9.4e-151	98.2
WP_001187875.1\|73574_74375_-	protein kilA	Q1MVK4	Enterobacteria_phage	1.9e-148	100.0
WP_023154138.1\|74539_75583_-	phage antirepressor protein	Q71TN2	Escherichia_phage	1.9e-185	97.7
WP_000245712.1\|75579_75801_-	host cell division inhibitor Icd-like protein	A0A077SLM6	Escherichia_phage	1.3e-38	100.0
WP_000908460.1\|76381_76699_+	hypothetical protein	Q71TC5	Escherichia_phage	2.9e-28	100.0
WP_024166536.1\|76706_77486_+	hypothetical protein	Q71TC6	Escherichia_phage	9.3e-145	96.1
WP_023153778.1\|77733_78300_+	hypothetical protein	Q1MVL0	Enterobacteria_phage	1.1e-99	99.5
WP_000523980.1\|78310_78922_+	hypothetical protein	Q71TN8	Escherichia_phage	2.9e-109	99.5
WP_000926342.1\|78936_79818_+	hypothetical protein	Q71TC9	Escherichia_phage	2.7e-172	98.6
WP_089477381.1\|79899_83595_+	transglycosylase SLT domain-containing protein	A0A1B0VDM8	Salmonella_phage	0.0e+00	85.8
WP_000002800.1\|83594_83951_+	hypothetical protein	Q71TP1	Escherichia_phage	1.0e-61	100.0
WP_000047924.1\|83947_85381_+	bleomycin hydrolase	A0A1B0VAD6	Salmonella_phage	1.1e-271	99.8
WP_001189832.1\|85380_86217_+	hypothetical protein	A0A1B0V7F2	Salmonella_phage	1.4e-154	100.0
WP_001286325.1\|86295_86730_+	hypothetical protein	A0A077SLL3	Escherichia_phage	7.4e-75	99.3
WP_105375182.1\|86741_89666_+\|tail	phage tail protein	A0A1B0V7G4	Salmonella_phage	3.8e-13	44.7
WP_023156927.1\|89676_90105_+\|tail	tail fiber protein	A0A0F7LCR3	Escherichia_phage	1.3e-39	54.9
WP_071961623.1\|90115_90574_+\|tail	tail fiber protein	A0A0F7LCR3	Escherichia_phage	1.4e-44	57.4
WP_000367942.1\|90573_91185_+\|tail	tail fiber assembly protein	M1SV83	Escherichia_phage	3.6e-83	78.6
WP_072196854.1\|91190_91688_-\|tail	tail fiber protein	K7P7Q7	Enterobacteria_phage	2.9e-43	57.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP027134

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP027134_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027134_1

599552-599701

Orphan

Consensus_repeat	Method
CGCGTCTTATCAGGCCTACGAGTTCGGTGCTGTGTAGGTCGGATAAGGCGTTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP027134_1

>merge|NZ_CP027134|1|599552-599701|CRISPRCasFinder
CGCGTCTTATCAGGCCTACGAGTTCGGTGCTGTGTAGGTCGGATAAGGCGTTCATGCCGCATCCGACAATAACAGCATTGCCTGATGCGACGCTTGCGCGTCTTATCAGGCCTACGAGTTCAGTGCTGTGTAGGTCGGATAAGGCGTTCA

>NZ_CP027134|1|1|599552-599701|CRISPRCasFinder
CGCGTCTTATCAGGCCTACGAGTTCGGTGCTGTGTAGGTCGGATAAGGCGTTCA	TGCCGCATCCGACAATAACAGCATTGCCTGATGCGACGCTTG
CGCGTCTTATCAGGCCTACGAGTTCAGTGCTGTGTAGGTCGGATAAGGCGTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027134.1\|WP_000036448.1\|590858_592454_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027134.1\|WP_021523335.1\|603858_605361_-\|DUF853-domain-containing-protein	unknown	unknown	gnl\|CDD\|283518
NZ_CP027134.1\|WP_000416387.1\|596085_598941_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NZ_CP027134.1\|WP_001128347.1\|606503_607823_-\|gnt-II-system-L-idonate-transporter	unknown	unknown	gnl\|CDD\|129873
NZ_CP027134.1\|WP_001295681.1\|602615_603698_+\|LPS-export-ABC-transporter-permease-LptG	unknown	unknown	gnl\|CDD\|237900
NZ_CP027134.1\|WP_001059412.1\|594137_594641_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP027134.1\|WP_001326836.1\|590283_590736_+\|YhcH/YjgK/YiaL-family-protein	unknown	unknown	gnl\|CDD\|225345
NZ_CP027134.1\|WP_000002953.1\|593675_594092_+\|ribonuclease-E-inhibitor-RraB	unknown	unknown	gnl\|CDD\|236876
NZ_CP027134.1\|WP_016245205.1\|594833_596030_+\|DUF898-domain-containing-protein	unknown	unknown	gnl\|CDD\|226719
NZ_CP027134.1\|WP_001309159.1\|605438_606437_-\|DNA-binding-transcriptional-regulator-IdnR	unknown	unknown	gnl\|CDD\|380489
NZ_CP027134.1\|WP_000584114.1\|601515_602616_+\|LPS-export-ABC-transporter-permease-LptF	unknown	unknown	gnl\|CDD\|185075
NZ_CP027134.1\|WP_000256681.1\|589545_590139_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP027134.1\|WP_000998695.1\|607885_608650_-\|gluconate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|181225
NZ_CP027134.1\|WP_001318460.1\|610488_611508_-\|NADPH-dependent-aldehyde-reductase-Ahr	unknown	unknown	gnl\|CDD\|176186
NZ_CP027134.1\|WP_000896738.1\|609921_610485_+\|gluconokinase	unknown	unknown	gnl\|CDD\|182097
NZ_CP027134.1\|WP_001197411.1\|608673_609705_-\|L-idonate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|182130
NZ_CP027134.1\|WP_000500687.1\|588761_589475_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|183714
NZ_CP027134.1\|WP_000397144.1\|599737_601249_-\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863
NZ_CP027134.1\|WP_000786399.1\|598940_599384_-\|DNA-polymerase-III-subunit-chi	unknown	unknown	gnl\|CDD\|235581
NZ_CP027134.1\|WP_000012907.1\|592509_593514_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|179587

Protein	Function_ID	Function_description	E-value
NZ_CP027134.1\|WP_021523335.1\|603858_605361_-\|DUF853-domain-containing-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_CP027134.1\|WP_000416387.1\|596085_598941_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_CP027134.1\|WP_001128347.1\|606503_607823_-\|gnt-II-system-L-idonate-transporter	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP027134.1\|WP_001295681.1\|602615_603698_+\|LPS-export-ABC-transporter-permease-LptG	gnl\|CDD\|237900	PRK15071, PRK15071, lipopolysaccharide ABC transporter permease; Provisional.	0
NZ_CP027134.1\|WP_001059412.1\|594137_594641_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.73712e-19
NZ_CP027134.1\|WP_001326836.1\|590283_590736_+\|YhcH/YjgK/YiaL-family-protein	gnl\|CDD\|225345	COG2731, EbgC, Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism].	3.64234e-69
NZ_CP027134.1\|WP_000002953.1\|593675_594092_+\|ribonuclease-E-inhibitor-RraB	gnl\|CDD\|236876	PRK11191, PRK11191, ribonuclease E inhibitor RraB.	4.50628e-69
NZ_CP027134.1\|WP_016245205.1\|594833_596030_+\|DUF898-domain-containing-protein	gnl\|CDD\|226719	COG4269, COG4269, Predicted membrane protein [Function unknown].	3.05031e-150
NZ_CP027134.1\|WP_001309159.1\|605438_606437_-\|DNA-binding-transcriptional-regulator-IdnR	gnl\|CDD\|380489	cd01575, PBP1_GntR, ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators. This group represents the ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of GntR is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding, which in turn changes the DNA binding affinity of the repressor.	1.4437e-109
NZ_CP027134.1\|WP_000584114.1\|601515_602616_+\|LPS-export-ABC-transporter-permease-LptF	gnl\|CDD\|185075	PRK15120, PRK15120, lipopolysaccharide ABC transporter permease LptF; Provisional.	0
NZ_CP027134.1\|WP_000256681.1\|589545_590139_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.07846e-09
NZ_CP027134.1\|WP_000998695.1\|607885_608650_-\|gluconate-5-dehydrogenase	gnl\|CDD\|181225	PRK08085, PRK08085, gluconate 5-dehydrogenase; Provisional.	0
NZ_CP027134.1\|WP_001318460.1\|610488_611508_-\|NADPH-dependent-aldehyde-reductase-Ahr	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.21683e-169
NZ_CP027134.1\|WP_000896738.1\|609921_610485_+\|gluconokinase	gnl\|CDD\|182097	PRK09825, idnK, gluconokinase.	1.3617e-126
NZ_CP027134.1\|WP_001197411.1\|608673_609705_-\|L-idonate-5-dehydrogenase	gnl\|CDD\|182130	PRK09880, PRK09880, L-idonate 5-dehydrogenase; Provisional.	0
NZ_CP027134.1\|WP_000500687.1\|588761_589475_-\|SDR-family-oxidoreductase	gnl\|CDD\|183714	PRK12742, PRK12742, SDR family oxidoreductase.	5.2218e-149
NZ_CP027134.1\|WP_000397144.1\|599737_601249_-\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0
NZ_CP027134.1\|WP_000786399.1\|598940_599384_-\|DNA-polymerase-III-subunit-chi	gnl\|CDD\|235581	PRK05728, PRK05728, DNA polymerase III subunit chi; Validated.	5.53743e-66
NZ_CP027134.1\|WP_000012907.1\|592509_593514_-\|ornithine-carbamoyltransferase	gnl\|CDD\|179587	PRK03515, PRK03515, ornithine carbamoyltransferase subunit I; Provisional.	0

>NZ_CP027134.1|WP_000786399.1|598940_599384_-|DNA-polymerase-III-subunit-chi
MKNATFYLLDNDTTVDGLSAVEQLVCEIAAERWRSGKRVLIACEDEKQAYRLDEALWARPAESFVPHNLAGEGPRGGAPVEIAWPQKRSSSPRDILISLRTSFADFATAFTEVVDFVPYEDSLKQLARERYKAYRVAGFNLNTATWK
>NZ_CP027134.1|WP_000416387.1|596085_598941_-|valine--tRNA-ligase
MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKTADGKDYLVVATTRPETLLGDTGVAVNPEDPRYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAQVFDTKGNESDVYSSEIPAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRNEDEVRKENNLGADVALRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKDENGKPQVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGISLPELLEKRTGNMMQPQLADKIRKRTEKQFPNGIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEGQDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKVLCGITADTIMLQPFPQYDASQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAERRVNENRGFLQTLARLESITVLPADNKGPVSVTKIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLEGYAEAKAKLIEQQAVIAAL
>NZ_CP027134.1|WP_016245205.1|594833_596030_+|DUF898-domain-containing-protein
MAQVINEMDVPSHSFVFHGTGERYFLICVVNVLLTIITLGIYLPWALMKCKRYLYANMEVNGQRFSYGITGGNVFVSCLVFVFFYFAILMTVSADMPLVGCVLTLSLLVLLIFMAAKGLRYQALMTSLNGVRFSFNCSLKRFWWVTFFLPILMAIGMGAVFFISTKMLHANSSSSVIISVVLMAIVGIVSIGIFNGTLYSLVMSFLWSNTSFGIHRFKVKLDTTYCIKYAILAFLALLPFLAVAGYIIFDQILNAYDSSVYANDDIENLQQFMEMQRKMIIAQLIYYFGIAVSTSYLTVSLRNHFMSNLSLNDGRIRFRSTLTYHGMLYRMCALVVISGITGGLAYPLLKIWMIDWQAKNTYLLGDLDDLPLINKEEQPDKGFLARISRGIMPSLPFL
>NZ_CP027134.1|WP_001059412.1|594137_594641_-|GNAT-family-N-acetyltransferase
MNNIAPQSPVMRRLTQQDNPAIARVIRQVSAEYGLTADKGYTVADPNLDELYQVYSQPGHAYWVVEFDGEVVGGGGIAPLAGSESDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHIDYALGCTGHVDCEVRMLREL
>NZ_CP027134.1|WP_000002953.1|593675_594092_+|ribonuclease-E-inhibitor-RraB
MANPEQLEEQREETRLIIEELLEDGSDPDALYTIEHHLSADDLETLEKAAVEAFKLGYEVTDPEELEVEDGDIVICCDILSECALNADLIDAQVEQLMTLAEKFDVEYDGWGTYFEDPNGEDGDDEDFVDEDDDGVRH
>NZ_CP027134.1|WP_000012907.1|592509_593514_-|ornithine-carbamoyltransferase
MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLVAPQACWPEAALVTECRALAQQNGGNITLTEDVAKGVEGADFIYTDVWVSMGEAKEKWAERIALLRDYQVNSKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSK
>NZ_CP027134.1|WP_000036448.1|590858_592454_+|hypothetical-protein
MSKISDLNYSQHITLADNFKQKSEVLNTWRVGMNNFARNAEGQDNTRNILDPKTFLEFLVKIFTLGYVDFSNRSNEAGRNMMAHIESSSYIKNNDGSEIMKFVMNNPEGERADLSKVEIEITLSTITTMGTRQGHTAIIFQQPDGSTNRYEGKSFERKDESSLHLITNKVLACYQREANKEVALLLNNHQLNWKDAIDYNELLEKPLASTLEKIKKEHLLLMPHVCDDTIPYLLGEGGILEEINGLKTLHDTKIDSGTEGNDEINNIKINLSNILIDSLDDAKINLEKVIDSMLETFFKLPYINDVKILEWCFNQSMQYSDDTTKIKHARSVIDHIDFNCDQSKIAETLFFNLNKEPYKNSPELQELIWEKLVVYVNDFNLSNQEKSRLILRLFDDVKLVFDKVPLSILVNDIFLKDFFMKQPDFAKWYFYQLLKSYEGEQMYLNELGYVYGDEEKTKEIVNKLPGYVVKIFEEKIDNELKIRTRMMEILRDEQINIYEYINEKQLEKLNPQGNLRIAIEKFGWNNKPITA
>NZ_CP027134.1|WP_001326836.1|590283_590736_+|YhcH/YjgK/YiaL-family-protein
MIIGNIHNLQPWLPQELRQAIEHIKAHVTPETPKGKHDIEGNRLFYLISEDMTEPYEARRAEYHARYLDIQIVLRGQEGMTFSTQPAGTPDTDWLADKDIAFLPEGVDEKTVILNEGDFVVFYPGEVHKPLCAVGAPAQVRKAVVKMLMA
>NZ_CP027134.1|WP_000256681.1|589545_590139_+|TetR/AcrR-family-transcriptional-regulator
MVTKKQSRVPGRPRRFAPEQAVSAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKVGLFSRVLNEYVGTEAIPLADILRDDRPVGECLVEVLKEAARRYSQNGGCAGCMVLEGIHSHDPQARDIAVQYYHAAETTIYDYIARRHPQSAQCVTDFMSTVMSGLSAKAREGHSIEQLCATAALAGEAIKTILKE
>NZ_CP027134.1|WP_000500687.1|588761_589475_-|SDR-family-oxidoreductase
MGAFTGKTVLILGGSRGIGAAIVRRFVTDGANVRFTYAGSKDAAEHLAQETGATAVFTDSADRDAVIDVVRKSGALDILVVNAGIGVFGDALELNADDIDRLFKINIHAPYHASVEAARQMPEGGRILIIGSVNGDRMPVAGMAAYAASKSALQGMARGLARDFGPRGITINVVQPGPIDTDANPANGPMRDMLHSLMAIKRHGQPEEVAGMVAWLAGPEASFVTGAMHTIDGAFGA
>NZ_CP027134.1|WP_000397144.1|599737_601249_-|leucyl-aminopeptidase
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
>NZ_CP027134.1|WP_000584114.1|601515_602616_+|LPS-export-ABC-transporter-permease-LptF
MIIIRYLVRETLKSQLAILFILLLIFFCQKLVRILGAAVDGDIPANLVLSLLGLGVPEMAQLILPLSLFLGLLMTLGKLYTESEITVMHACGLSKAVLVKAAMILAVFTAIVAAVNVMWAGPWSSRHQDEVLAEAKANPGMAALAQGQFQQATNGSSVLFIESVDGSDFKDVFLAQIRPKGNARPSVVVADSGHLTQLRDGSQVVTLNQGTRFEGTALLRDFRITDFQDYQAIIGHQAVALDPNDTDQMDMRTLWNTDTDRARAELNWRITLVFTVFMMALMVVPLSVVNPRQGRVLSMLPAMLLYLLFFLIQTSLKSNGGKGKLDPTLWMWTVNLIYLALAIVLNLWDTVPVRRLRASFSRKGAV
>NZ_CP027134.1|WP_001295681.1|602615_603698_+|LPS-export-ABC-transporter-permease-LptG
MQPFGVLDRYIGKTIFTTIMMTLFMLVSLSGIIKFVDQLKKAGQGSYDALGAGMYTLLSVPKDVQIFFPMAALLGALLGLGMLAQRSELVVMQASGFTRMQVALSVMKTAIPLVLLTMAIGEWVAPQGEQMARNYRAQAMYGGSLLSTQQGLWAKDGNNFVYIERVKGDEELGGISIYAFNENRRLQSVRYAATAKFDPEHKVWRLSQVDESDLTNPKQITGSQTVSGTWKTNLTPDKLGVVALDPDALSISGLHNYVKYLKSSGQDAGRYQLNMWSKIFQPLSVAVMMLMALSFIFGPLRSVPMGVRVVTGISFGFVFYVLDQIFGPLTLVYGIPPIIGALLPSASFFLISLWLLMRKS
>NZ_CP027134.1|WP_021523335.1|603858_605361_-|DUF853-domain-containing-protein
MSEPLLIARTPDTELFLLPGMANRHGLITGATGTGKTVTLQKLAESLSEIGVPVFMADVKGDLTGVAQAGTVSEKLLARLKNIGVNDWQPHANPVVVWDIFGEKGHPVRATVSDLGPLLLARLLNLNDVQSGVLNIIFRIADDQGLLLLDFKDLRAITQYIGDNAKSFQNQYGNISSASVGAIQRGLLSLEQQGAAHFFGEPMLDIKDWMRTDANGKGVINILSAEKLYQMPKLYAASLLWMLSELYEQLPEAGDLEKPKLVFFFDETHLLFNDAPQVLLDKIEQVIRLIRSKGVGVWFVSQNPSDIPDNVLGQLGNRVQHALRAFTPKDQKAVKAAAQTMRANPAFDTEKAIQELGTGEALISFLDAKGSPSVVERAMVIAPCSRMGPVTEDERNGLINHSPVYGKYEDEVDRESAYEMLQKGFQASTEQQNNPPAKGKEVAVDDGILGGLKDILFGTTGPRGGKKDGVVQTMAKSAARQVTNQIVRGMLGSLLGGRRR
>NZ_CP027134.1|WP_001309159.1|605438_606437_-|DNA-binding-transcriptional-regulator-IdnR
MRNHRISLQDIATLAGVTKMTVSRYIRSPKKVAKETGERIAKIMEEINYIPNRAPGMLLNAQSYTLGILIPSFQNQLFADILAGIESVTSEHNYQTLIANYNYDRDSEEESVINLLSYNIDGIILSEKYHTIRTVKFLRSATIPVVELMDVQGERLDMEVGFDNRQAAFDMVCTMLEKRVRHKILYLGSKDDTRDEQRYQGYCDAMMLHNLSPLRMNPRAISSIHLGMQLMRDALSANPDLDGVFCTNDDIAMGALLLCRERNLAVPEQISIAGFHGLEIGRQMIPSLASVITPRFDIGRMAAQMLLSKIKNNDHNHNTVDLGYQIYHGNTL
>NZ_CP027134.1|WP_001128347.1|606503_607823_-|gnt-II-system-L-idonate-transporter
MPLIIIAAGVALLLILMIVFKVNGFIALVLVAAVVGFAEGMDAQAVLHSIQNGIGSTLGGLAMILGFGAMLGKLISDTGAAQRIATTLIATFGKKRVQWALVITGLVVGLAMFFEVGFVLLLPLVFTIVASSGLPLLYVGVPMVAALSVTHCFLPPHPGPTAIATIFEANLGTTLLYGFIITIPTVIVAGPLFSKLLTRFEKAPPEGLFNPHLFSEEEMPSFWNSIFAAVIPVILMAIAAVCEITLPKTNTVRLFFEFVGNPAVALFIAIVIAIFTLGRRNGRTIEQIMDIIGDSIGAIAMIVFIIAGGGAFKQVLVDSGVGHYISHLMTGTTLSPLLMCWTVAALLRIALGSATVAAITTAGVVLPIINVTHADPALMVLATGAGSVIASHVNDPGFWLFKGYFNLTVGETLRTWTVMETLISIMGLLGVLAINAVLH
>NZ_CP027134.1|WP_000998695.1|607885_608650_-|gluconate-5-dehydrogenase
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELARHNIQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVNGHLLFVDGGMLVAV
>NZ_CP027134.1|WP_001197411.1|608673_609705_-|L-idonate-5-dehydrogenase
MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIHSDSSELHEGQTVAINPSKPCGHCKYCIEHNENQCTDMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKADEKVMAFAEPLAVAIHAAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLRGSFRFTSEFNTAVSWLANGVINPLPLLSAEYPFTDLEEALRFAGDKTQAAKVQLVF
>NZ_CP027134.1|WP_000896738.1|609921_610485_+|gluconokinase
MAGESFILMGVSGSGKTLIGSKVAALLSAKFIDGDDLHPAKNIDKMSQGIPLSDEDRLPWLERLNDASYSLYKKNETGFIVCSSLKKQYRDILRKGSPHVHFLWLDGDYETILARMQRRAGHFMPVALLKSQFEALERPQADEQDIVRIDINHDIANVTEQCRQAVLAIRQNRICAKEGSASDQRCE
>NZ_CP027134.1|WP_001318460.1|610488_611508_-|NADPH-dependent-aldehyde-reductase-Ahr
MSMIKSYAAKEAGGELEVYEYDPGELRPQDVEVQVDYCGICHSDLSMIDNEWGFSQYPLVAGHEVIGRVVALGSAAQDKGLQVGQRVGIGWTARSCGHCDACISGNQINCEQGAVPTIMNRGGFAEKLRADWQWVIPLPENIDIESAGPLLCGGITVFKPLLMHHITATSRVGVIGIGGLGHIAIKLLHAMGCEVTAFSSNPAKEQEVLAMGADKVVNSRDPQALKALAGQFDLIINTVNVSLDWQPYFEALTYGGNFHTVGAVLTPLSVPAFTLIAGDRSVSGSATGTPYELRKLMRFAARSKVAPTTELFPMSKINDAIQHVRDGKARYRVVLKADY

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Crispr_ID: NZ_CP027134_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027134_2

3987561-3988138

TypeI-E

I-E

Consensus_repeat	Method
CGATTTATCCCCGCTGGCGCGGGGAACAC	PILER-CR
TTTATCCCCGCTGGCGCGGGGAACAC	CRISPRCasFinder
TTTATCCCCGCTGGCGCGGGGAACAC	CRT

9 spacers

cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NZ_CP027134_2

>merge|NZ_CP027134|2|3987561-3988138|PILER-CR,CRISPRCasFinder,CRT
CGGTTTATCCCCGCTGACGCGGGGAACACGTCAATAGGCGGCGTCCCGTAGCCGTCCCCTTCGGTTTATCCCCGCTGGCGCGGGGAACACGTTGAGGTCGATAAGTACGAACGGTTTCCCTGCGGTTTATCCCCGCTGGCGCGGGGAACACGATCGCCTGCTCCAGCGTCACTCCCTGCCCCTCGATTTATCCCCGCTGGCGCGGGGAACACTTCTGATACGTACTGAGGCCGGTTGTGATACGCGATTTATCCCCGCTGGCGCGGGGAACACTAACCCCCAATGAAGTTAATAAAGTCTATGGCCGATTTATCCCCGCTGGCGCGGGGAACACATGAGATTAAAATACTCAGTACTCTTACTCGCCGATTTATCCCCGCTGGCGCGGGGAACACCAGCGTGGCGCGATAAAGCAATGTGTCTGGCTCGATTTATCCCCGCTGGCGCGGGGAACACCAGAGGCAACCGACGCGGATTCAGTAGGAAAGCGATTTATCCCCGCTGGCGCGGGGAACACCGATAGACACTTTGCGGTCATTGTCTATTCGGCGATTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027134|2|1|3987561-3988138|PILER-CR
CGGTTTATCCCCGCTGACGCGGGGAACAC	GTCAATAGGCGGCGTCCCGTAGCCGTCCCCTT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GTTGAGGTCGATAAGTACGAACGGTTTCCCTG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GATCGCCTGCTCCAGCGTCACTCCCTGCCCCT
CGATTTATCCCCGCTGGCGCGGGGAACAC	TTCTGATACGTACTGAGGCCGGTTGTGATACG
CGATTTATCCCCGCTGGCGCGGGGAACAC	TAACCCCCAATGAAGTTAATAAAGTCTATGGC
CGATTTATCCCCGCTGGCGCGGGGAACAC	ATGAGATTAAAATACTCAGTACTCTTACTCGC
CGATTTATCCCCGCTGGCGCGGGGAACAC	CAGCGTGGCGCGATAAAGCAATGTGTCTGGCT
CGATTTATCCCCGCTGGCGCGGGGAACAC	CAGAGGCAACCGACGCGGATTCAGTAGGAAAG
CGATTTATCCCCGCTGGCGCGGGGAACAC	CGATAGACACTTTGCGGTCATTGTCTATTCGG
CGATTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027134|2|2|3987564-3988138|CRISPRCasFinder
TTTATCCCCGCTGACGCGGGGAACAC	GTCAATAGGCGGCGTCCCGTAGCCGTCCCCTTCGG
TTTATCCCCGCTGGCGCGGGGAACAC	GTTGAGGTCGATAAGTACGAACGGTTTCCCTGCGG
TTTATCCCCGCTGGCGCGGGGAACAC	GATCGCCTGCTCCAGCGTCACTCCCTGCCCCTCGA
TTTATCCCCGCTGGCGCGGGGAACAC	TTCTGATACGTACTGAGGCCGGTTGTGATACGCGA
TTTATCCCCGCTGGCGCGGGGAACAC	TAACCCCCAATGAAGTTAATAAAGTCTATGGCCGA
TTTATCCCCGCTGGCGCGGGGAACAC	ATGAGATTAAAATACTCAGTACTCTTACTCGCCGA
TTTATCCCCGCTGGCGCGGGGAACAC	CAGCGTGGCGCGATAAAGCAATGTGTCTGGCTCGA
TTTATCCCCGCTGGCGCGGGGAACAC	CAGAGGCAACCGACGCGGATTCAGTAGGAAAGCGA
TTTATCCCCGCTGGCGCGGGGAACAC	CGATAGACACTTTGCGGTCATTGTCTATTCGGCGA
TTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027134|2|1|3987564-3988138|CRT
TTTATCCCCGCTGACGCGGGGAACAC	GTCAATAGGCGGCGTCCCGTAGCCGTCCCCTTCGG
TTTATCCCCGCTGGCGCGGGGAACAC	GTTGAGGTCGATAAGTACGAACGGTTTCCCTGCGG
TTTATCCCCGCTGGCGCGGGGAACAC	GATCGCCTGCTCCAGCGTCACTCCCTGCCCCTCGA
TTTATCCCCGCTGGCGCGGGGAACAC	TTCTGATACGTACTGAGGCCGGTTGTGATACGCGA
TTTATCCCCGCTGGCGCGGGGAACAC	TAACCCCCAATGAAGTTAATAAAGTCTATGGCCGA
TTTATCCCCGCTGGCGCGGGGAACAC	ATGAGATTAAAATACTCAGTACTCTTACTCGCCGA
TTTATCCCCGCTGGCGCGGGGAACAC	CAGCGTGGCGCGATAAAGCAATGTGTCTGGCTCGA
TTTATCCCCGCTGGCGCGGGGAACAC	CAGAGGCAACCGACGCGGATTCAGTAGGAAAGCGA
TTTATCCCCGCTGGCGCGGGGAACAC	CGATAGACACTTTGCGGTCATTGTCTATTCGGCGA
TTTATCCCCGCTGGCGCGGGGAACAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027134.1\|WP_000144858.1\|3988524_3989448_-\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NZ_CP027134.1\|WP_001521153.1\|3986441_3987479_+\|alkaline-phosphatase-isozyme-conversion-aminopeptidase	unknown	unknown	gnl\|CDD\|182299
NZ_CP027134.1\|WP_020234039.1\|3990076_3990823_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|187776
NZ_CP027134.1\|WP_000568924.1\|3980115_3981165_-\|tRNA-pseudouridine(13)-synthase-TruD	unknown	unknown	gnl\|CDD\|234884
NZ_CP027134.1\|WP_001521158.1\|3994096_3996796_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP027134.1\|WP_001090361.1\|3983852_3985280_-\|sulfate-adenylyltransferase-subunit-CysN	unknown	unknown	gnl\|CDD\|235349
NZ_CP027134.1\|WP_000956458.1\|3996990_3997143_-\|type-I-toxin-antitoxin-system-Hok-family-toxin	unknown	unknown	gnl\|CDD\|366840
NZ_CP027134.1\|WP_001521155.1\|3989444_3990095_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09664_cas6e_CAS-I-E	gnl\|CDD\|273869
NZ_CP027134.1\|WP_000029331.1\|3991903_3992440_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09731_cse2gr11_CAS-I-E	gnl\|CDD\|187862
NZ_CP027134.1\|WP_000517476.1\|3982369_3982681_-\|cell-division-protein-FtsB	unknown	unknown	gnl\|CDD\|179156
NZ_CP027134.1\|WP_000246138.1\|3981640_3982351_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NZ_CP027134.1\|WP_001246104.1\|3982874_3983198_-\|DUF3561-family-protein	unknown	unknown	gnl\|CDD\|371891
NZ_CP027134.1\|WP_001521157.1\|3990833_3991889_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	cd09646_cas7_CAS-I-E	gnl\|CDD\|273843
NZ_CP027134.1\|WP_001295182.1\|3979373_3980135_-\|5'/3'-nucleotidase-SurE	unknown	unknown	gnl\|CDD\|234732
NZ_CP027134.1\|WP_001084115.1\|3992436_3993999_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09669_cas8e_CAS-I-E	gnl\|CDD\|274192
NZ_CP027134.1\|WP_001173673.1\|3983247_3983853_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|179661
NZ_CP027134.1\|WP_001521160.1\|3997407_3998142_-\|phosphoadenosine-phosphosulfate-reductase	unknown	unknown	gnl\|CDD\|234997
NZ_CP027134.1\|WP_001521152.1\|3981161_3981641_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|178851
NZ_CP027134.1\|WP_000372392.1\|3985281_3986190_-\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_CP027134.1\|WP_001521154.1\|3988234_3988528_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	cd09648_cas2_CAS-I-E	gnl\|CDD\|236930

Protein	Function_ID	Function_description	E-value
NZ_CP027134.1\|WP_000144858.1\|3988524_3989448_-\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	1.11358e-157
NZ_CP027134.1\|WP_001521153.1\|3986441_3987479_+\|alkaline-phosphatase-isozyme-conversion-aminopeptidase	gnl\|CDD\|182299	PRK10199, PRK10199, alkaline phosphatase isozyme conversion aminopeptidase; Provisional.	0
NZ_CP027134.1\|WP_020234039.1\|3990076_3990823_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187776	cd09645, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	7.25317e-47
NZ_CP027134.1\|WP_000568924.1\|3980115_3981165_-\|tRNA-pseudouridine(13)-synthase-TruD	gnl\|CDD\|234884	PRK00984, truD, tRNA pseudouridine synthase D; Reviewed.	0
NZ_CP027134.1\|WP_001521158.1\|3994096_3996796_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	0
NZ_CP027134.1\|WP_001090361.1\|3983852_3985280_-\|sulfate-adenylyltransferase-subunit-CysN	gnl\|CDD\|235349	PRK05124, cysN, sulfate adenylyltransferase subunit 1; Provisional.	0
NZ_CP027134.1\|WP_000956458.1\|3996990_3997143_-\|type-I-toxin-antitoxin-system-Hok-family-toxin	gnl\|CDD\|366840	pfam01848, HOK_GEF, Hok/gef family.	8.32243e-12
NZ_CP027134.1\|WP_001521155.1\|3989444_3990095_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|273869	TIGR01907, CRISPR_system_Cascade_subunit_CasE, CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family, represented by CT1974 from Chlorobium tepidum, is found in the Ecoli subtype of CRISPR/Cas regions and is designated Cse3 (CRISPR/Cas Subtype Ecoli protein 3). The representative of this family from Thermus thermophilus HB8 (TTHB192) has been crystallized and found to have a structure consisting of two domains with opposing parallel beta-sheets known as a beta-sheet platform. This structure is similar to those found in the Sex-lethal protein and poly(A)-binding protein. This structure is consistent with an RNA-binding function.	3.05036e-90
NZ_CP027134.1\|WP_000029331.1\|3991903_3992440_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|187862	cd09731, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	4.72866e-28
NZ_CP027134.1\|WP_000517476.1\|3982369_3982681_-\|cell-division-protein-FtsB	gnl\|CDD\|179156	PRK00888, ftsB, cell division protein FtsB; Reviewed.	5.55235e-62
NZ_CP027134.1\|WP_000246138.1\|3981640_3982351_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	3.26939e-121
NZ_CP027134.1\|WP_001246104.1\|3982874_3983198_-\|DUF3561-family-protein	gnl\|CDD\|371891	pfam12084, DUF3561, Protein of unknown function (DUF3561). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.	1.22003e-52
NZ_CP027134.1\|WP_001521157.1\|3990833_3991889_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|273843	TIGR01869, CRISPR_system_Cascade_subunit_CasC, CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum and is part of the Ecoli subtype of CRISPR/Cas locis. It is designated Cse4, for CRISPR/Cas Subtype Ecoli protein 4.	7.45078e-156
NZ_CP027134.1\|WP_001295182.1\|3979373_3980135_-\|5'/3'-nucleotidase-SurE	gnl\|CDD\|234732	PRK00346, surE, 5'(3')-nucleotidase/polyphosphatase; Provisional.	1.92279e-150
NZ_CP027134.1\|WP_001084115.1\|3992436_3993999_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|274192	TIGR02547, CRISPR_system_Cascade_subunit_CasA, CRISPR type I-E/ECOLI-associated protein CasA/Cse1. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family, represented by CT1972 from Chlorobium tepidum, is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It is designated Cse1.	0
NZ_CP027134.1\|WP_001173673.1\|3983247_3983853_-\|adenylyl-sulfate-kinase	gnl\|CDD\|179661	PRK03846, PRK03846, adenylylsulfate kinase; Provisional.	7.34447e-148
NZ_CP027134.1\|WP_001521160.1\|3997407_3998142_-\|phosphoadenosine-phosphosulfate-reductase	gnl\|CDD\|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	4.91666e-137
NZ_CP027134.1\|WP_001521152.1\|3981161_3981641_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|178851	PRK00084, ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed.	2.39634e-105
NZ_CP027134.1\|WP_000372392.1\|3985281_3986190_-\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP027134.1\|WP_001521154.1\|3988234_3988528_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	9.65861e-64

>NZ_CP027134.1|WP_001521153.1|3986441_3987479_+|alkaline-phosphatase-isozyme-conversion-aminopeptidase
MFSALRHRTAALALGVCFILPVHASSAKPGDFANTQARHIATFFPGRMTGTPAEMLSADYIRQQFQQMGYRSDIRTFNSRYIYTARDNRKSWHNVTGSTVIAAHEGKAPQQIIIMAHLDTYAPLSDADADANLGGLTLQGMDDNAAGLGVMLELAERLKNTPTEYGIRFVATSGEEEGKLGAENLLKRMSDTEKKNTLLVINLDNLIVGDKLYFNSGVKTPEAVRKLTRDRALAIARSHGIAATTNPGLNKNYPKGTGCCNDAEVFDKAGIAVLSVEATNWNLGNKDGYQQRAKTAAFPAGNSWHDVRLDNQQHIDKALPGRIERRCRDVMRIMLPLVKELAKAS
>NZ_CP027134.1|WP_000372392.1|3985281_3986190_-|sulfate-adenylyltransferase-subunit-CysD
MDQKRLTHLRQLEAESIHIIREVAAEFSNPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYEFRDRTAKAYGCELLVHKNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMIDDNRIDLQPGEVIKKRMVRFRTLGCWPLTGAVESNAQTLPEIIEEMLVSTTSERQGRVIDRDQAGSMELKKRQGYF
>NZ_CP027134.1|WP_001090361.1|3983852_3985280_-|sulfate-adenylyltransferase-subunit-CysN
MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYSEETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPVSQATAAPSEFSAFELELNALVRRHFPHWGARDLLGDK
>NZ_CP027134.1|WP_001173673.1|3983247_3983853_-|adenylyl-sulfate-kinase
MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
>NZ_CP027134.1|WP_001246104.1|3982874_3983198_-|DUF3561-family-protein
MRNSHNITLTNNDSLTEDEETTWSLPGAVVGFISWLFALAMPMLIYGSNTLFFFIYTWPFFLALMPVAVVVGIALHSLMDGKLRYSIVFTLVTVGIMFGALFMWLLG
>NZ_CP027134.1|WP_000517476.1|3982369_3982681_-|cell-division-protein-FtsB
MGKLTLLLLAILVWLQYSLWFGKNGIHDYTRVNDDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTRPGETFYRLVPDASKRAQSAGQNNR
>NZ_CP027134.1|WP_000246138.1|3981640_3982351_-|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
>NZ_CP027134.1|WP_001521152.1|3981161_3981641_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MRIGHGFDVHAFGGEGPLIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
>NZ_CP027134.1|WP_000568924.1|3980115_3981165_-|tRNA-pseudouridine(13)-synthase-TruD
MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
>NZ_CP027134.1|WP_001295182.1|3979373_3980135_-|5'/3'-nucleotidase-SurE
MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
>NZ_CP027134.1|WP_001521154.1|3988234_3988528_-|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MSMVVVVTENVPPRLRGRIAIWLLEVRAGVYVGDTSKRIREMIWQQISQLAGCGNVVMAWATNTESGFEFQTWGENRRIPVDLDGVRLVSFLPVDNQ
>NZ_CP027134.1|WP_000144858.1|3988524_3989448_-|type-I-E-CRISPR-associated-endonuclease-Cas1
MTFVPLSPIPLKDRTSMIFLQYGQIDVLDGAFVLIDKTGIRTHIPVGSVACIMLEPGTRVSHAAVHLAATVGTLLVWVGEAGVRVYSSGQPGGARADKLLYQAKLALTEDLRLKVVRKMYELRFREPPPARRSVEQLRGIEGSRVRQTYALLAKQYGVKWNGRKYDPKDWEKGDVVNRCISAATSCLYGISEAAVLAAGYAPAIGFIHSGKPLSFVYDIADIIKFDSVVPKAFEIAARQPAEPDKEVRLACRDIFRSSKLTGKLIPLIEEVLAAGEIEPPQPAPDMLPPAIPEPETLGDSGHRGRGG
>NZ_CP027134.1|WP_001521155.1|3989444_3990095_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRITLHTGQLLPAQLLHLVGRGEYVMHQWLWDLFPGGKERQFLYRREELQGAFRFFVLSQERPAESDIFTIECRPFAPELRTGQSLCFNLRANPTICKAGKRHDLLMEAKRQVRGQVEGSDVWLHQQQAALDWLAAQGERSGFTLLDTSVDAYRQQQLRRENSRQLIQFSSVDYTGMLTVTDPGLFLQRLSQGYGKSRAFGCGLMLIKPGAEA
>NZ_CP027134.1|WP_020234039.1|3990076_3990823_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSQYLIFQLHGPMASWGVDAPGEVRHTHELPSRSALLGLLAAGVGIRRDDTERLNAFNRHYSLVVCASRNPRWARDYHTVQMPKEVRKARYFSRREELSAPDLLSAIISRRDYYTDAWWMVAVATTPDASYRLEQLQDGLRHPVFPLYLGRKSHPLALPLAPLLLEGNASDVLRNAYQQYQDSFRELKVSLPKLQDECWWEGEHDGLVASKILRRRDVPLNRQQWLFGERTINQGPWLSKEEPCTSQE
>NZ_CP027134.1|WP_001521157.1|3990833_3991889_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTTFIQLHLLTAYPAANLNRDDTGAPKTVVLGGATRLRVSSQSLKRAWRTSALFEQALAGHIGIRSGRIAREAATILIEKGIEEKKAIEWAAKIADYLGKAKNDKKPKDPLTNAETEQLVHISPAEFDAVKALAHQLAEEKRAPKEEDLALLRKDRMAVDIAMFGRMLANKPEFNVEAACQVAHAFGVSETIVEDDFFTAVDDLRQASEDAGAGHLGETGFGSALFYTYICIDKDLLVENLGGDEALANQTLRAFTEAALKVSPTGKQNSFASRAYASWALAEKGTEQPRSLAAAFYEPINGTRQLDVAVQRITTLRENMNTVYEQKTECVSFDVMNKQGSMKDVLDFICA
>NZ_CP027134.1|WP_000029331.1|3991903_3992440_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MSIVKEEHKATLRKWHEELQEKRGNRASLRRSTTVNDVCLSEGFRSLLMQTHTLWKIEAQEWRFTALALVAAVSANVKAIDERQPFAAQLAAVMSEGRFTRLSAVKTPDDLLRQLRRAVKLLNGSVNLISLAEDIFRWCQESDDLLNHHRRQQRPTEFIRIRWALEYYQAGDADNEQN
>NZ_CP027134.1|WP_001084115.1|3992436_3993999_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MNSFSLLTTPWLPVRYKDGTTGKLAPVDLADENVVDIAAPRADLQGAAWQFLLGLLQTSFAPKDHRRWDDIWEDGLESEKLREALLSLEHAFQFGPDSPSFMQDFEALTGDKVQVASLLPEIPGAQTTKFNKDHFIKRGVTEYLCPHCSALALFSLQLNAPSGGKGYRTGLRGGGPMTTLIELQEYQGNQQTPLWRKLWLNVMPQDEADLPLPKKFDDLVFPWLGPTRTSELAGAVVTDDQVNKLQAYWGMPRRIRIDFNTTTVGNCDICGEQNDALLSLMTTKNYGANYAMWQHPLTPYRVPLKEGGEFYSVKPQPGGLIWRDWLGLIETGKSENNTELPALVVKLFNASSLKQAKVGLWGFGYDFDNMKARCWYEHHFPLLLDKKEGQIPKLRLAAQTASRILSLLRSALKEAWFSDPKGARGDFSFVDIDFWNKTQHRFLRLVRHIEEGQDADELLSKWQKEIWLFARQDFDERVFTNPYEPVDLKRVMTARKKYFTTSAEKQNAKAAREKKQEAAE
>NZ_CP027134.1|WP_001521158.1|3994096_3996796_-|CRISPR-associated-helicase/endonuclease-Cas3
MRKYPLSLLKDKNIVTFFDFWGKTRRGEKDGGDDYHLLCWHSLDVAAMGYLMVKSNCFGLTDYFRQLGFADTEQAAQFFAWLLCWHDTGKFARSFQQLYLHPQLKVPEGARKNYEKISHSTLGYWLWHHYLSEYEELLPSSSLSPRKLKRVMEMWMPITTGHHGRPPDRIDELDNFLPEDKAAARDFLLEIKPLFPLIEIPAFWDDDEGIELIKHLSWYISATVVLADWTGSSTRFFPRVAHPMDIKGYWQKTLVQAQNALTVFPLKAKVAPFTGINTLFPFIENPTPLQQKVLDLDISQPGPQLFILEDVTGAGKTEAALILAHRLMAAGKAQGLFFGLPTMATANAMYDRLVKTWLAFYSPESRPSLVLAHSARTLMDRFNESLWSGDLVGSEEPDEQTFSQGCAAWFADSNKKALLAEIGVGTLDQAMMAVMPFKHNNLRLLGLSNKILLADEIHACDAYMSCILEGLIERQARGGNSVILLSATLSQQQCDKLVAAFARGTEGQQEAPFLEKDDYPWLTHVTKSDVHSHRVATRKDVERSVSVGWLHSEQECIARIESAVSQGKCIAWIRNSVDDAIKVYRQLLARGVIPASSLSLFHSRFAFSDRQRIETETLARFGKEDSSQRAGKVLICTQVLESSVDCDMDEMISDLAPVDLLIQRAGRLQRHIRDINGQLKRDGKDERSPPELLILAPVWDDAPGDEWFGSAMRNSAYVYPDHGRIWLTQRVLREQGAIQMPHAARLLIESVYGEDVVMPEGFARSEQEQVGKYYCDRAMAKKFVLNFRPGYAANINDYLPEKLSTRLAEESVSLWLATCIASVVKPYANGAHAWEMSVVRVRRSWWKKHRDEFSLLEGEAFRQWCIEQRKDPEMANVILVTDDESCGYSAMEGLTGKVG
>NZ_CP027134.1|WP_000956458.1|3996990_3997143_-|type-I-toxin-antitoxin-system-Hok-family-toxin
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK
>NZ_CP027134.1|WP_001521160.1|3997407_3998142_-|phosphoadenosine-phosphosulfate-reductase
MSKLDLNALNELPKVDRILALAETNAELEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQIRPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNAQTWFAGLRREQSGSRTNLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG

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Crispr_ID: NZ_CP027134_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027134_3

4015276-4015914

Orphan

I-E

Consensus_repeat	Method
CGGTTTATCCCCGCTGGCGCGGGGAACTC	CRISPRCasFinder
CGGTTTATCCCCGCTGGCGCGGGGAACTC	CRT
CTCGGTTTATCCCCGCTGGCGCGGGGAACTC	PILER-CR

10 spacers

The CRISPR arrays of NZ_CP027134_3

>merge|NZ_CP027134|3|4015276-4015914|CRISPRCasFinder,CRT,PILER-CR
TGGTTTATTCCCGCTGGTGCGGGGAACTCATCAGTGATATCCAACATTGCGGAGCTAAACGCGGTTTATCCCCGCTGGCGCGGGGAACTCACGAACGCGGCACACCAGGGCGTCTCATCGTCCGGTTTATCCCCGCTGGCGCGGGGAACTCGGCACATGCCTGATCATATGTGTAGCAACGGTCGGTTTATCCCCGCTGGCGCGGGGAACTCACGATGTATGACCGGAAAACCTCAGACTGGCGCGGTTTATCCCCGCTGGCGCGGGGAACTCACGATGTATGACCGGAAAACCTCAGACTGGCGCGGTTTATCCCCGCTGGCGCGGGGAACTCGCCGCGTTATTTTCCCTGAAAACAATAAAGCTCGGTTTATCCCCGCTGGCGCGGGGAACTCTAATATCCCTGGCGATAATCAACCGGCTTACTCGGTTTATCCCCGCTGGCGCGGGGAACTCGAGAGCGAGGGGAGATTCCGGCAGGGCGTGCACGGTTTATCCCCGCTGGCGCGGGGAACTCGCGGGTATGCTCCGCTCCGTGTTCGACAAACTCGGTTTATCCCCGCTGGCGCGGGGAACTCAAGGTCGCGGGGACGCCACGGGCAGTCAATGTCGGTTTATCCCCGCTGGCGCGGGGAACTC

>NZ_CP027134|3|3|4015276-4015914|CRISPRCasFinder
TGGTTTATTCCCGCTGGTGCGGGGAACTC	ATCAGTGATATCCAACATTGCGGAGCTAAACG
CGGTTTATCCCCGCTGGCGCGGGGAACTC	ACGAACGCGGCACACCAGGGCGTCTCATCGTC
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GGCACATGCCTGATCATATGTGTAGCAACGGT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	ACGATGTATGACCGGAAAACCTCAGACTGGCG
CGGTTTATCCCCGCTGGCGCGGGGAACTC	ACGATGTATGACCGGAAAACCTCAGACTGGCG
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GCCGCGTTATTTTCCCTGAAAACAATAAAGCT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	TAATATCCCTGGCGATAATCAACCGGCTTACT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GAGAGCGAGGGGAGATTCCGGCAGGGCGTGCA
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GCGGGTATGCTCCGCTCCGTGTTCGACAAACT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	AAGGTCGCGGGGACGCCACGGGCAGTCAATGT
CGGTTTATCCCCGCTGGCGCGGGGAACTC

>NZ_CP027134|3|2|4015276-4015914|CRT
TGGTTTATTCCCGCTGGTGCGGGGAACTC	ATCAGTGATATCCAACATTGCGGAGCTAAACG
CGGTTTATCCCCGCTGGCGCGGGGAACTC	ACGAACGCGGCACACCAGGGCGTCTCATCGTC
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GGCACATGCCTGATCATATGTGTAGCAACGGT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	ACGATGTATGACCGGAAAACCTCAGACTGGCG
CGGTTTATCCCCGCTGGCGCGGGGAACTC	ACGATGTATGACCGGAAAACCTCAGACTGGCG
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GCCGCGTTATTTTCCCTGAAAACAATAAAGCT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	TAATATCCCTGGCGATAATCAACCGGCTTACT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GAGAGCGAGGGGAGATTCCGGCAGGGCGTGCA
CGGTTTATCCCCGCTGGCGCGGGGAACTC	GCGGGTATGCTCCGCTCCGTGTTCGACAAACT
CGGTTTATCCCCGCTGGCGCGGGGAACTC	AAGGTCGCGGGGACGCCACGGGCAGTCAATGT
CGGTTTATCCCCGCTGGCGCGGGGAACTC

>NZ_CP027134|3|2|4015640-4015914|PILER-CR
CTCGGTTTATCCCCGCTGGCGCGGGGAACTC	TAATATCCCTGGCGATAATCAACCGGCTTA
CTCGGTTTATCCCCGCTGGCGCGGGGAACTC	GAGAGCGAGGGGAGATTCCGGCAGGGCGTG
CACGGTTTATCCCCGCTGGCGCGGGGAACTC	GCGGGTATGCTCCGCTCCGTGTTCGACAAA
CTCGGTTTATCCCCGCTGGCGCGGGGAACTC	AAGGTCGCGGGGACGCCACGGGCAGTCAAT
GTCGGTTTATCCCCGCTGGCGCGGGGAACTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027134.1\|WP_000036723.1\|4018859_4020158_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP027134.1\|WP_001199973.1\|4016252_4016924_-\|7-carboxy-7-deazaguanine-synthase-QueE	unknown	unknown	gnl\|CDD\|275126
NZ_CP027134.1\|WP_000059301.1\|4009227_4010682_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP027134.1\|WP_100190663.1\|4004734_4006083_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP027134.1\|WP_001521167.1\|4007039_4007819_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
NZ_CP027134.1\|WP_000147654.1\|4007796_4009206_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP027134.1\|WP_000581937.1\|4023307_4023556_-\|type-II-toxin-antitoxin-system-antitoxin-MazE	unknown	unknown	gnl\|CDD\|182082
NZ_CP027134.1\|WP_001071643.1\|4022109_4022901_-\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|236569
NZ_CP027134.1\|WP_000039721.1\|4013159_4014638_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|212662
NZ_CP027134.1\|WP_162854589.1\|4006182_4007076_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP027134.1\|WP_020232912.1\|4017217_4018090_+\|YgcG-family-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP027134.1\|WP_020233775.1\|4011855_4013133_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP027134.1\|WP_000109536.1\|4003747_4004008_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|225289
NZ_CP027134.1\|WP_001521172.1\|4025915_4027217_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|237291
NZ_CP027134.1\|WP_000210878.1\|4020244_4021882_-\|CTP-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|235437
NZ_CP027134.1\|WP_001130266.1\|4004024_4004600_+\|glycerol-3-phosphate-responsive-antiterminator	unknown	unknown	gnl\|CDD\|224865
NZ_CP027134.1\|WP_000226798.1\|4023633_4025868_-\|GTP-diphosphokinase	unknown	unknown	gnl\|CDD\|182797
NZ_CP027134.1\|WP_000254738.1\|4022972_4023308_-\|endoribonuclease-MazF	unknown	unknown	gnl\|CDD\|182138
NZ_CP027134.1\|WP_021523232.1\|4010751_4011537_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
NZ_CP027134.1\|WP_000526135.1\|4018208_4018667_-\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|224854

Protein	Function_ID	Function_description	E-value
NZ_CP027134.1\|WP_000036723.1\|4018859_4020158_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP027134.1\|WP_001199973.1\|4016252_4016924_-\|7-carboxy-7-deazaguanine-synthase-QueE	gnl\|CDD\|275126	TIGR04322, organic_radical_activating_enzyme, putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE. Members of this radical SAM domain protein family appear to be the E. coli form of the queuosine biosynthesis protein QueE. QueE is involved in making preQ0 (7-cyano-7-deazaquanine), a precursor of both the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. Members occur in species that lack known forms of QueE but usually are not found in queuosine biosynthesis operons. Members of this family tend to form bi-directional best hit matches to members of known (TIGR03365) and putative (TIGR03963) QueE families from other lineages.	3.98248e-155
NZ_CP027134.1\|WP_000059301.1\|4009227_4010682_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.6361e-82
NZ_CP027134.1\|WP_100190663.1\|4004734_4006083_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.29095e-52
NZ_CP027134.1\|WP_001521167.1\|4007039_4007819_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	8.81851e-61
NZ_CP027134.1\|WP_000147654.1\|4007796_4009206_-\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.45668e-51
NZ_CP027134.1\|WP_000581937.1\|4023307_4023556_-\|type-II-toxin-antitoxin-system-antitoxin-MazE	gnl\|CDD\|182082	PRK09798, PRK09798, MazF-MazE toxin-antitoxin system antitoxin MazE.	6.19513e-48
NZ_CP027134.1\|WP_001071643.1\|4022109_4022901_-\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|236569	PRK09562, mazG, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	9.36315e-160
NZ_CP027134.1\|WP_000039721.1\|4013159_4014638_+\|sugar-kinase	gnl\|CDD\|212662	cd07779, FGGY_ygcE_like, uncharacterized ygcE-like proteins. This subfamily consists of uncharacterized hypothetical bacterial proteins with similarity to Escherichia coli sugar kinase ygcE , whose functional roles are not yet clear. Escherichia coli ygcE is recognized by this model, but is not present in the alignment as it contains a deletion relative to other members of the group. These proteins belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	2.76431e-108
NZ_CP027134.1\|WP_162854589.1\|4006182_4007076_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	8.28502e-89
NZ_CP027134.1\|WP_020232912.1\|4017217_4018090_+\|YgcG-family-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	6.02863e-94
NZ_CP027134.1\|WP_020233775.1\|4011855_4013133_+\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	1.01506e-28
NZ_CP027134.1\|WP_000109536.1\|4003747_4004008_+\|ferredoxin-family-protein	gnl\|CDD\|225289	COG2440, FixX, Ferredoxin-like protein [Energy production and conversion].	4.39108e-42
NZ_CP027134.1\|WP_001521172.1\|4025915_4027217_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|237291	PRK13168, rumA, 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD.	0
NZ_CP027134.1\|WP_000210878.1\|4020244_4021882_-\|CTP-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NZ_CP027134.1\|WP_001130266.1\|4004024_4004600_+\|glycerol-3-phosphate-responsive-antiterminator	gnl\|CDD\|224865	COG1954, GlpP, Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription].	5.83077e-88
NZ_CP027134.1\|WP_000226798.1\|4023633_4025868_-\|GTP-diphosphokinase	gnl\|CDD\|182797	PRK10872, relA, (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional.	0
NZ_CP027134.1\|WP_000254738.1\|4022972_4023308_-\|endoribonuclease-MazF	gnl\|CDD\|182138	PRK09907, PRK09907, endoribonuclease MazF.	1.17475e-74
NZ_CP027134.1\|WP_021523232.1\|4010751_4011537_-\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.07958e-139
NZ_CP027134.1\|WP_000526135.1\|4018208_4018667_-\|IS200/IS605-family-transposase	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	6.62797e-46

>NZ_CP027134.1|WP_000039721.1|4013159_4014638_+|sugar-kinase
MSKKYIIGIDGGSQSTKVVMYDLEGNVVCEGKGLLQPMHTPDADTAEHPDDDLWASLCFAGHDLMSQFAGNKEDIVGIGLGSIRCCRALLKADGTPAAPLISWQDARVTRPYEHTNPDVAYVTSFSGYLTHRLTGEFKDNIANYFGQWPVDYKTWAWSEDAAVMEKFNIPRHMLFDVQMPGTVLGHITPQAALATHFPAGLPVVCTTSDKPVEALGAGLLDDETAVISLGTYIALMMNGKLLPKDPVAYWPIMSSIPQTLLYEGYGIRKGMWTVSWLRDMLGESLIQDAKAQDLSPEDLLNKKASCVPPGCNGLMTVLDWLTNPWEPYKRGIMIGFDSSMDYAWIYRSILESVALTLKNNYDNMCNEMNHFAKHVIITGGGSNSDLFMQIFADVFNLPARRNAINGCASLGAAINTAVGLGLYPDYATAVDKMVRVKDIFMPVESNAKRYNAMNKGIFKELTKHTDVILKKSYEVMHGELGNADSIQSWSNA
>NZ_CP027134.1|WP_020233775.1|4011855_4013133_+|MFS-transporter
MQHNSYRRWIALAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTILMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFAPDDSASLKTVIIIYSVVYILLGILCWFFVSDNNNLRSANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASYMGIVINKIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALLVTNSNPQSVAMGIGLILLLGFTCYASRGLYWACPGEARTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDTLPAAEAYRNMWLMGMAALAMVIVFTFLLFQKIRTADSAPAMASSK
>NZ_CP027134.1|WP_021523232.1|4010751_4011537_-|SDR-family-oxidoreductase
MSIESLNALSMDFFSLKGKTAIVTGGNSGLGQAFAMALAKAGANIFIPSFVKDNGETKEMIEKQGVEVDFMQVDITAEGAPQKIIAACCERFGTVDILINNAGICKLNKVLDFGRADWDPMIDVNLTAAFELSYEAAKIMIPQKSGKIINICSLFSYLGGQWSPAYSATKHALAGFTKAYCDELGQYNIQVNGIAPGYYATDITLATRSNPETNQRVLDHIPANRWGDTQDLMGAAVFLASPASNYVNGHLLVVDGGYLVR
>NZ_CP027134.1|WP_000059301.1|4009227_4010682_-|FAD-binding-oxidoreductase
MSLSRAAIVDQLKEIVGADRVITDETVLKKNSIDRFRKFPDIHGIYTLPIPAAVVKLGSTEQVSRVLNFMNAHKINGVPRTGASATEGGLETVVENSVVLDGSAMNQIINIDIENMQATAQCGVPLEVLENALREKGYTTGHSPQSKPLAQMGGLVATRSIGQFSTLYGAIEDMVVGLEAVLADGTVTRIKNVPRRAAGPDIRHIIIGNEGALCYITEVTVKIFKFTPENNLFYGYILEDMKTGFNILREIMVEGYRPSIARLYDAEDGTQHFTHFADGKCVLIFMAEGNPRIAKATGEGIAEIVARYPQCQRVDSKLIETWFNNLNWGPDKVAAERVQILKTGNMGFTTEVSGCWSCIHEIYESVINRIRTEFPHADDITMLGGHSSHSYQNGTNMYFVYDYNVVDCKPEEEIDKYHNPLNKIICEETIRLGGSMVHHHGIGKHRVHWSKLEHGSAWTLLEGLKKQFDPNGIMNTGTIYPIEK
>NZ_CP027134.1|WP_000147654.1|4007796_4009206_-|MFS-transporter
MTGRCLFGFSGEKPFLLPDNEGIKMNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISESPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVATATHKHIKTLFSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLAAVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV
>NZ_CP027134.1|WP_001521167.1|4007039_4007819_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNILLAFKAEPDAGMLAEKEWQAAAQGNSGPDVSLLRSLLGADEQAAAALLLAQRKNGTSMSLTALSMGDERALHWLRYLMALGFEEAVLLETAADLRFAPEFVARHIAEWQYQNPLELIITGCQSSEGQNGQTPFLLAEMLGWPCFTQVERFTLDAPFITLEQRTENGLRCCRVRLPAVIAVRQCGEVALPVPGMRQRMAVGKAAIIRKTVAAESPAMQCLQLARAEQQRGATLIDGQTVAEKAQKLWQDYLRQRMQP
>NZ_CP027134.1|WP_162854589.1|4006182_4007076_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAGLFTPKDAAMNIAIVTINQENAATASWQAAQDFSGCTLAHWKIEPQPAVAEQVLDALVEQWQRTPADVVLFPPGTFGDELSTRLAWRLHGASICQVTSLDIPTVSVRKSHWGNALTATLQTEKRPLCLSLARQAGADKNATLPSGMQQLNIVPGALPDWLVSIENLKNVTRDPLAEARRVLVVGQGGEADNQEIAMLAEKLGAEVGYSRARVMNGGVDAEKVIGISGHLLAPEVCIVVGASGAAALMAGVRNSKFVVAINHDASAAVFSQADVGVVDDWKVVLEALVTNIHAECQ
>NZ_CP027134.1|WP_100190663.1|4004734_4006083_+|IS3-family-transposase
MKHSFEVKLAAVNHYLAGHAGIISTAKLFQLSHTSLSHWINLFLLHGPRALDCRHKRSYSPEDKLCVVLYALGHSESLPRVAARFNIPSHNTVKNWIKGYRKSGNEAFIRRRKEKSMTRSDDTHENEANMTPEEMKNELRYLRAENAYLKAMQEHLLEKKPPGAGEKTKVIRSLRCGHCQSDLLKAAGLARSTLYYQLSLQKAKDKYADVKQLIASIFHEHRGCYGYRRIHCELQKRGLKFSGKTVRKLMQQLGLKSPVRLKKYRSYRGNMGLAAENILQRQFKAEAPCEKWVTDITEFRAGGQKLYLSPILDLFNGEIVAWETACRPTEELVKRMLNKGLESLAEGEKPLLHSDQGWHYRIKSYQSALADRGLVQSMSRKGNCLDNAVMENFFGHLKEEMYYRRDYRNVEELENAVNEYITYWNQKRIKLSLGGLSPVEYRTEHQKAG
>NZ_CP027134.1|WP_001130266.1|4004024_4004600_+|glycerol-3-phosphate-responsive-antiterminator
MPLLHLLRQNPVIAAVKDNASLQLAIDSECQFISVLYGNICTISNIVKKIKNAGKYAFIHVDLLEGASNKEVVIQFLKLVTEADGIISTKASMLKAARAEGFFCIHRLFIVDSISFHNIDKQVAQSNPDCIEILPGCMPKVLGWVTEKIRQPLIAGGLVCDEEDARNAINAGVVALSTTNTGVWTLAKKLL
>NZ_CP027134.1|WP_000109536.1|4003747_4004008_+|ferredoxin-family-protein
MSVARNLWRVADAPHIVPADSVERQTVQRLINACPAGLFSLTPEGDLRVDYRGCLECGTCRLLCDESTLQQWRYPPSGFGITYRFG
>NZ_CP027134.1|WP_001199973.1|4016252_4016924_-|7-carboxy-7-deazaguanine-synthase-QueE
MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWEKLEDREVSLFSILAKTKESDKWGAASSEDLLAVIGRQGYTARHVVITGGEPCIHDLLPLTDLLEKNGFSCQIETSGTHEVRCTPNTWVTVSPKLNMRGGYEVLSQALERANEIKHPVGRVRDIEALDELLATLTDDKPRVIALQPISQKDDATRLCIETCIARNWRLSMQTHKYLNIA
>NZ_CP027134.1|WP_020232912.1|4017217_4018090_+|YgcG-family-protein
MRYFILIFTFVCSFIAAQPTIVPSLQQQVTDLTSSLNSQEKKELTYKLESIFNNTQVQIAVLIVPTTKDETIEKYATRVFDNWRLGDAKRNDGILIIVAWSDRTVRIQVGYGLEEKVTDALAGDIIRSNMIPAFKQQKLAQGLELAINALNNQLTSQHQYPANPSEIESASSSDHYYFAIFWVFAVMFFPFWFFHQGSNFCRACKSSVCISAIYLLDLFLFSDKTFSIAVFFFFFTFTTIMVFTCLCVLQKRASGRSYHSDNSGSAGGSDSGGFSDGGGSSGGGGASGRW
>NZ_CP027134.1|WP_000526135.1|4018208_4018667_-|IS200/IS605-family-transposase
MGNEKSLAHTRWNCKYHIVFAPKYRRQVFYREKRRAIGSILRKLCEWKSVRILEAECCADHIHMLVEIPPKMSVSGFMGYLKGKSSLMLYEQFGDLKFKYRNREFWCRGYYVDTVGKNTAKIQDYIKHQLEEDKMGEQLSIPYPGSPFTGRK
>NZ_CP027134.1|WP_000036723.1|4018859_4020158_-|phosphopyruvate-hydratase
MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
>NZ_CP027134.1|WP_000210878.1|4020244_4021882_-|CTP-synthase-(glutamine-hydrolyzing)
MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANSTEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQCQLVDDSLVRQLYNAPTIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEFQKRQAK
>NZ_CP027134.1|WP_001071643.1|4022109_4022901_-|nucleoside-triphosphate-pyrophosphohydrolase
MNQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVIDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL
>NZ_CP027134.1|WP_000254738.1|4022972_4023308_-|endoribonuclease-MazF
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
>NZ_CP027134.1|WP_000581937.1|4023307_4023556_-|type-II-toxin-antitoxin-system-antitoxin-MazE
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKEVW
>NZ_CP027134.1|WP_000226798.1|4023633_4025868_-|GTP-diphosphokinase
MVAVRSAHINKAGEFDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRECVGKSVVNLIHGVRDMAAIRQLKATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEIQIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKEAEKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKPSAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRLHGS
>NZ_CP027134.1|WP_001521172.1|4025915_4027217_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MAQFYSAKRRTTTRQIITVSVNDLDSFGQGVARHNGKALFIPGLLPQENAEVTVTEDKKQYARAKVVRRLSDNPERETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKHEVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKAGSSDIVDVKQCPILVPQLEALLPKVRACLDSLQAMRHLGHVELVQATSGTLMILRHTAPLSSADREKLERFSHSEGLDLYLAPDSEILETVAGEMPWYDSNGLRLTFSPRDFIQVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFTLPLATQAASVVGVEGVPALVEKGQQNARLNGLHNVTFYHENLEEDVTKQPWAKNGFDKVLLDPARAGAAGVMQQIIKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAMLDMFPHTGHLESMVLFSRVK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP027134_2	2.6\|3987895\|32\|NZ_CP027134\|PILER-CR	3987895-3987926	32	NZ_CP037443	Klebsiella sp. PO552 plasmid p2, complete sequence	42679-42710	1	0.969
NZ_CP027134_2	2.15\|3987895\|35\|NZ_CP027134\|CRISPRCasFinder,CRT	3987895-3987929	35	NZ_CP037443	Klebsiella sp. PO552 plasmid p2, complete sequence	42676-42710	2	0.943
NZ_CP027134_3	3.2\|4015366\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015366-4015397	32	KT898133	Aeromonas phage phiARM81ld, complete genome	45655-45686	2	0.938
NZ_CP027134_3	3.14\|4015854\|30\|NZ_CP027134\|PILER-CR	4015854-4015883	30	NC_008712	Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence	320389-320418	5	0.833
NZ_CP027134_3	3.8\|4015732\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015732-4015763	32	NC_016040	Sulfobacillus thermotolerans strain Y0017 plasmid pY0017, complete sequence	37866-37897	6	0.812
NZ_CP027134_3	3.12\|4015732\|30\|NZ_CP027134\|PILER-CR	4015732-4015761	30	NC_016040	Sulfobacillus thermotolerans strain Y0017 plasmid pY0017, complete sequence	37868-37897	6	0.8
NZ_CP027134_2	2.3\|3987712\|32\|NZ_CP027134\|PILER-CR	3987712-3987743	32	MT110073	Stenotrophomonas phage vB_SmaS_DLP_3, complete genome	39410-39441	7	0.781
NZ_CP027134_3	3.6\|4015610\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015610-4015641	32	KC821619	Cellulophaga phage phi18:1, complete genome	6924-6955	7	0.781
NZ_CP027134_3	3.6\|4015610\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015610-4015641	32	KC821627	Cellulophaga phage phi18:2, complete genome	6924-6955	7	0.781
NZ_CP027134_3	3.14\|4015854\|30\|NZ_CP027134\|PILER-CR	4015854-4015883	30	NZ_CP045381	Labrenzia sp. THAF35 plasmid pTHAF35_a, complete sequence	107507-107536	7	0.767
NZ_CP027134_3	3.14\|4015854\|30\|NZ_CP027134\|PILER-CR	4015854-4015883	30	NZ_CP019631	Labrenzia aggregata strain RMAR6-6 plasmid unnamed1, complete sequence	199281-199310	7	0.767
NZ_CP027134_2	2.2\|3987651\|32\|NZ_CP027134\|PILER-CR	3987651-3987682	32	NZ_CP044084	Pseudomonas luteola strain FDAARGOS_637 plasmid unnamed1, complete sequence	347859-347890	8	0.75
NZ_CP027134_2	2.5\|3987834\|32\|NZ_CP027134\|PILER-CR	3987834-3987865	32	KC847113	Bacillus phage PBP180, complete sequence	100-131	8	0.75
NZ_CP027134_3	3.2\|4015366\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015366-4015397	32	MN901520	Halorubrum coriense virus Hardycor2, complete genome	16524-16555	8	0.75
NZ_CP027134_3	3.7\|4015671\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015671-4015702	32	MN855878	Bacteriophage sp. isolate 336, complete genome	5171-5202	8	0.75
NZ_CP027134_3	3.10\|4015854\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015854-4015885	32	NZ_CP045381	Labrenzia sp. THAF35 plasmid pTHAF35_a, complete sequence	107507-107538	8	0.75
NZ_CP027134_3	3.10\|4015854\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015854-4015885	32	NZ_CP019631	Labrenzia aggregata strain RMAR6-6 plasmid unnamed1, complete sequence	199281-199312	8	0.75
NZ_CP027134_2	2.1\|3987590\|32\|NZ_CP027134\|PILER-CR	3987590-3987621	32	NZ_CP016293	Rhizobium leguminosarum strain Vaf10 plasmid unnamed5, complete sequence	11267-11298	9	0.719
NZ_CP027134_2	2.5\|3987834\|32\|NZ_CP027134\|PILER-CR	3987834-3987865	32	NZ_CP038863	Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence	20152-20183	9	0.719
NZ_CP027134_2	2.5\|3987834\|32\|NZ_CP027134\|PILER-CR	3987834-3987865	32	NC_049837	Klebsiella phage vB_KpnS_Alina, complete genome	13583-13614	9	0.719
NZ_CP027134_2	2.6\|3987895\|32\|NZ_CP027134\|PILER-CR	3987895-3987926	32	NZ_CP019063	Rahnella sp. ERMR1:05 plasmid unnamed1, complete sequence	287201-287232	9	0.719
NZ_CP027134_3	3.6\|4015610\|32\|NZ_CP027134\|CRISPRCasFinder,CRT	4015610-4015641	32	NZ_CP020483	Campylobacter helveticus strain ATCC 51209 plasmid pHELV-5, complete sequence	383-414	9	0.719
NZ_CP027134_2	2.5\|3987834\|32\|NZ_CP027134\|PILER-CR	3987834-3987865	32	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	179050-179081	10	0.688
NZ_CP027134_2	2.14\|3987834\|35\|NZ_CP027134\|CRISPRCasFinder,CRT	3987834-3987868	35	NZ_CP038863	Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence	20152-20186	12	0.657

1. spacer 2.6|3987895|32|NZ_CP027134|PILER-CR matches to NZ_CP037443 (Klebsiella sp. PO552 plasmid p2, complete sequence) position: , mismatch: 1, identity: 0.969

atgagattaaaatactcagtactcttactcgc	CRISPR spacer
atgagattaaaatactcagcactcttactcgc	Protospacer
*******************.************

2. spacer 2.15|3987895|35|NZ_CP027134|CRISPRCasFinder,CRT matches to NZ_CP037443 (Klebsiella sp. PO552 plasmid p2, complete sequence) position: , mismatch: 2, identity: 0.943

atgagattaaaatactcagtactcttactcgccga	CRISPR spacer
atgagattaaaatactcagcactcttactcgccgt	Protospacer
*******************.**************

3. spacer 3.2|4015366|32|NZ_CP027134|CRISPRCasFinder,CRT matches to KT898133 (Aeromonas phage phiARM81ld, complete genome) position: , mismatch: 2, identity: 0.938

acgaacgcggcacaccagggcgtctcatcgtc	CRISPR spacer
acgaacgcggcgcaccagggcgtctcgtcgtc	Protospacer
***********.**************.*****

4. spacer 3.14|4015854|30|NZ_CP027134|PILER-CR matches to NC_008712 (Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence) position: , mismatch: 5, identity: 0.833

aaggtcgcggggacgccacgggcagtcaat	CRISPR spacer
caggtcggcgggacgccacgggcagtcgac	Protospacer
 ******  ******************.*.

5. spacer 3.8|4015732|32|NZ_CP027134|CRISPRCasFinder,CRT matches to NC_016040 (Sulfobacillus thermotolerans strain Y0017 plasmid pY0017, complete sequence) position: , mismatch: 6, identity: 0.812

gagagcgaggggagattccggcagggcgtgca	CRISPR spacer
aatcgtgaggggatcttccggcagggcgtgca	Protospacer
.*  *.*******  *****************

6. spacer 3.12|4015732|30|NZ_CP027134|PILER-CR matches to NC_016040 (Sulfobacillus thermotolerans strain Y0017 plasmid pY0017, complete sequence) position: , mismatch: 6, identity: 0.8

gagagcgaggggagattccggcagggcgtg	CRISPR spacer
aatcgtgaggggatcttccggcagggcgtg	Protospacer
.*  *.*******  ***************

7. spacer 2.3|3987712|32|NZ_CP027134|PILER-CR matches to MT110073 (Stenotrophomonas phage vB_SmaS_DLP_3, complete genome) position: , mismatch: 7, identity: 0.781

gatcgcctgctccagcgtcactccctgcccct	CRISPR spacer
gttcgcctgctccagcgtcaatgccccctccc	Protospacer
* ****************** * **. *.**.

8. spacer 3.6|4015610|32|NZ_CP027134|CRISPRCasFinder,CRT matches to KC821619 (Cellulophaga phage phi18:1, complete genome) position: , mismatch: 7, identity: 0.781

gccgcgttattttccctgaaaacaataaagct	CRISPR spacer
gcggttttattttccctgaaaagaaaaaagag	Protospacer
** *. **************** ** ****

9. spacer 3.6|4015610|32|NZ_CP027134|CRISPRCasFinder,CRT matches to KC821627 (Cellulophaga phage phi18:2, complete genome) position: , mismatch: 7, identity: 0.781

gccgcgttattttccctgaaaacaataaagct	CRISPR spacer
gcggttttattttccctgaaaagaaaaaagag	Protospacer
** *. **************** ** ****

10. spacer 3.14|4015854|30|NZ_CP027134|PILER-CR matches to NZ_CP045381 (Labrenzia sp. THAF35 plasmid pTHAF35_a, complete sequence) position: , mismatch: 7, identity: 0.767

aaggtcgcggggacgccacgggcagtcaat	CRISPR spacer
gatttcgctgggaccccacgggcagtcgac	Protospacer
.*  **** ***** ************.*.

11. spacer 3.14|4015854|30|NZ_CP027134|PILER-CR matches to NZ_CP019631 (Labrenzia aggregata strain RMAR6-6 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

aaggtcgcggggacgccacgggcagtcaat	CRISPR spacer
gatttcgctgggaccccacgggcagtcgac	Protospacer
.*  **** ***** ************.*.

12. spacer 2.2|3987651|32|NZ_CP027134|PILER-CR matches to NZ_CP044084 (Pseudomonas luteola strain FDAARGOS_637 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

gttgaggtcgataagtacgaacggtttccctg	CRISPR spacer
gaagaggtcgatgagtacgaatggttacagcg	Protospacer
*  *********.********.**** *  .*

13. spacer 2.5|3987834|32|NZ_CP027134|PILER-CR matches to KC847113 (Bacillus phage PBP180, complete sequence) position: , mismatch: 8, identity: 0.75

taacccccaatgaagttaataaagtctatggc	CRISPR spacer
ttctctctaatgtagttaataaagtcgatggt	Protospacer
*  .*.*.**** ************* ****.

14. spacer 3.2|4015366|32|NZ_CP027134|CRISPRCasFinder,CRT matches to MN901520 (Halorubrum coriense virus Hardycor2, complete genome) position: , mismatch: 8, identity: 0.75

acgaacgcggcacaccagggcgtctcatcgtc--	CRISPR spacer
ccgaacgcggcacacccgagcg--tcggcggcgg	Protospacer
 *************** *.***  **. ** *

15. spacer 3.7|4015671|32|NZ_CP027134|CRISPRCasFinder,CRT matches to MN855878 (Bacteriophage sp. isolate 336, complete genome) position: , mismatch: 8, identity: 0.75

taatatccc----tggcgataatcaaccggcttact	CRISPR spacer
----acgccatggtggcgataatcatcctgcttact	Protospacer
    *. **    ************ ** *******

16. spacer 3.10|4015854|32|NZ_CP027134|CRISPRCasFinder,CRT matches to NZ_CP045381 (Labrenzia sp. THAF35 plasmid pTHAF35_a, complete sequence) position: , mismatch: 8, identity: 0.75

aaggtcgcggggacgccacgggcagtcaatgt	CRISPR spacer
gatttcgctgggaccccacgggcagtcgacgg	Protospacer
.*  **** ***** ************.*.*

17. spacer 3.10|4015854|32|NZ_CP027134|CRISPRCasFinder,CRT matches to NZ_CP019631 (Labrenzia aggregata strain RMAR6-6 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

aaggtcgcggggacgccacgggcagtcaatgt	CRISPR spacer
gatttcgctgggaccccacgggcagtcgacgg	Protospacer
.*  **** ***** ************.*.*

18. spacer 2.1|3987590|32|NZ_CP027134|PILER-CR matches to NZ_CP016293 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed5, complete sequence) position: , mismatch: 9, identity: 0.719

gtcaataggcggcgtcccgtagccgtcccctt	CRISPR spacer
gtgctctggcggcgtgccgtagccatccccga	Protospacer
**   . ******** ********.*****

19. spacer 2.5|3987834|32|NZ_CP027134|PILER-CR matches to NZ_CP038863 (Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

taacccccaatgaagttaataaagtctatggc	CRISPR spacer
ctttaggcaatgaagttaaaaaattctatggc	Protospacer
.  .   ************ *** ********

20. spacer 2.5|3987834|32|NZ_CP027134|PILER-CR matches to NC_049837 (Klebsiella phage vB_KpnS_Alina, complete genome) position: , mismatch: 9, identity: 0.719

taacccccaatgaagttaataaagtctatggc	CRISPR spacer
acattggcgatgaagttaataacgtgtatggc	Protospacer
  *..  *.************* ** ******

21. spacer 2.6|3987895|32|NZ_CP027134|PILER-CR matches to NZ_CP019063 (Rahnella sp. ERMR1:05 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

atgagattaaaatactcagtactcttactcgc	CRISPR spacer
cgggaattaacatactcggtactcttaccgtc	Protospacer
  *..***** ******.**********.  *

22. spacer 3.6|4015610|32|NZ_CP027134|CRISPRCasFinder,CRT matches to NZ_CP020483 (Campylobacter helveticus strain ATCC 51209 plasmid pHELV-5, complete sequence) position: , mismatch: 9, identity: 0.719

gccgcgttattttccctgaaaacaataaagct	CRISPR spacer
tagcctttattttcactcaaaacaataaaagt	Protospacer
    * ******** ** ***********. *

23. spacer 2.5|3987834|32|NZ_CP027134|PILER-CR matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 10, identity: 0.688

taacccccaatgaagttaataaagtctatggc	CRISPR spacer
gtagattcaatgaagttaataaaaactatgat	Protospacer
  *  ..****************. *****..

24. spacer 2.14|3987834|35|NZ_CP027134|CRISPRCasFinder,CRT matches to NZ_CP038863 (Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence) position: , mismatch: 12, identity: 0.657

taacccccaatgaagttaataaagtctatggccga	CRISPR spacer
ctttaggcaatgaagttaaaaaattctatggcgat	Protospacer
.  .   ************ *** ******** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

572657 : 641078

uncultured_Caudovirales_phage(17.65%)

protease,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001162173.1\|572657_574010_+\|protease	metalloprotease PmbA	NA	NA	NA	NA
WP_001232246.1\|574193_574580_+	cytochrome b562	NA	NA	NA	NA
WP_000212715.1\|574771_575014_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	A0A2H4JBG1	uncultured_Caudovirales_phage	1.4e-14	50.0
WP_001105433.1\|575003_575294_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A2H4JBF4	uncultured_Caudovirales_phage	3.8e-27	63.8
WP_001009182.1\|575294_575759_-	anaerobic ribonucleoside-triphosphate reductase-activating protein	K4F9T1	Cronobacter_phage	8.5e-53	57.1
WP_000187798.1\|575943_578082_-	anaerobic ribonucleoside-triphosphate reductase	A0A2I7QNQ7	Vibrio_phage	1.5e-266	64.5
WP_021523332.1\|578475_580131_-	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_021523333.1\|580180_581602_-	PTS trehalose transporter subunit IIBC	NA	NA	NA	NA
WP_001181324.1\|581720_582668_-	HTH-type transcriptional regulator TreR	C6ZCU4	Enterobacteria_phage	7.9e-13	21.8
WP_001387276.1\|582852_582906_+	mgtA regulatory leader peptide MgtL	NA	NA	NA	NA
WP_000471850.1\|583046_585743_+	magnesium-translocating P-type ATPase	M1HLC0	Paramecium_bursaria_Chlorella_virus	3.4e-45	27.3
WP_000047539.1\|585948_586335_-	2-iminobutanoate/2-iminopropanoate deaminase	NA	NA	NA	NA
WP_000148581.1\|586407_586869_-	aspartate carbamoyltransferase regulatory subunit	NA	NA	NA	NA
WP_000013046.1\|586881_587817_-	aspartate carbamoyltransferase	M1HWF9	Paramecium_bursaria_Chlorella_virus	2.9e-52	40.2
WP_001296693.1\|587820_587955_-	pyr operon leader peptide	NA	NA	NA	NA
WP_000230281.1\|588235_588631_-	RidA family protein	NA	NA	NA	NA
WP_000500687.1\|588761_589475_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_000256681.1\|589545_590139_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_001326836.1\|590283_590736_+	YhcH/YjgK/YiaL family protein	NA	NA	NA	NA
WP_000036448.1\|590858_592454_+	hypothetical protein	NA	NA	NA	NA
WP_000012907.1\|592509_593514_-	ornithine carbamoyltransferase	NA	NA	NA	NA
WP_000002953.1\|593675_594092_+	ribonuclease E inhibitor RraB	NA	NA	NA	NA
WP_001059412.1\|594137_594641_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_016245205.1\|594833_596030_+	DUF898 domain-containing protein	NA	NA	NA	NA
WP_000416387.1\|596085_598941_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	1.3e-140	36.7
WP_000786399.1\|598940_599384_-	DNA polymerase III subunit chi	NA	NA	NA	NA
WP_000397144.1\|599737_601249_-	leucyl aminopeptidase	Q6GYZ8	Mycoplasma_phage	6.0e-47	38.0
WP_000584114.1\|601515_602616_+	LPS export ABC transporter permease LptF	NA	NA	NA	NA
WP_001295681.1\|602615_603698_+	LPS export ABC transporter permease LptG	NA	NA	NA	NA
WP_021523335.1\|603858_605361_-	DUF853 domain-containing protein	A0A248XCZ8	Klebsiella_phage	1.4e-83	43.9
WP_001309159.1\|605438_606437_-	DNA-binding transcriptional regulator IdnR	NA	NA	NA	NA
WP_001128347.1\|606503_607823_-	gnt-II system L-idonate transporter	NA	NA	NA	NA
WP_000998695.1\|607885_608650_-	gluconate 5-dehydrogenase	NA	NA	NA	NA
WP_001197411.1\|608673_609705_-	L-idonate 5-dehydrogenase	NA	NA	NA	NA
WP_000896738.1\|609921_610485_+	gluconokinase	NA	NA	NA	NA
WP_001318460.1\|610488_611508_-	NADPH-dependent aldehyde reductase Ahr	A0A0G2Y405	Acanthamoeba_polyphaga_mimivirus	1.4e-44	30.7
WP_000547193.1\|616065_617394_-\|transposase	IS4-like element IS4 family transposase	NA	NA	NA	NA
WP_000179691.1\|618020_619238_+	MFS transporter	NA	NA	NA	NA
WP_000611568.1\|619249_620368_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_000594405.1\|620410_620536_+	hypothetical protein	NA	NA	NA	NA
WP_000254999.1\|620588_620846_-	hypothetical protein	NA	NA	NA	NA
WP_085948656.1\|621159_622326_+\|transposase	IS3-like element IS911 family transposase	Q716C2	Shigella_phage	1.8e-184	99.3
WP_000625671.1\|622261_622675_-	DUF2254 domain-containing protein	NA	NA	NA	NA
WP_001293436.1\|622737_624735_-	BCCT family transporter	A0A2I7QNT1	Vibrio_phage	7.4e-21	25.9
WP_000336726.1\|624888_625707_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.2e-65	45.2
WP_000088391.1\|625742_626045_-\|transposase	transposase	NA	NA	NA	NA
WP_000177057.1\|626978_627236_+	hypothetical protein	NA	NA	NA	NA
WP_000175457.1\|627792_628560_-	Fe(3+) dicitrate ABC transporter ATP-binding protein FecE	G3M9Y6	Bacillus_virus	6.4e-13	24.8
WP_000684855.1\|628560_629517_-	Fe(3+) dicitrate ABC transporter permease subunit FecD	A0A2H4IY97	uncultured_Caudovirales_phage	2.4e-17	26.1
WP_000125187.1\|629513_630512_-	iron-dicitrate ABC transporter permease FecC	NA	NA	NA	NA
WP_000879164.1\|630508_631411_-	Fe(3+) dicitrate ABC transporter substrate-binding protein FecB	NA	NA	NA	NA
WP_000188262.1\|631455_633780_-	Fe(3+) dicitrate transport protein FecA	NA	NA	NA	NA
WP_001068913.1\|633866_634820_-	fec operon regulator FecR	NA	NA	NA	NA
WP_001283626.1\|634816_635338_-	RNA polymerase sigma factor FecI	NA	NA	NA	NA
WP_000555341.1\|637087_637345_+	hypothetical protein	NA	NA	NA	NA
WP_000823243.1\|638095_639454_+	esterase-like activity of phytase family protein	NA	NA	NA	NA
WP_086352845.1\|639692_641078_-\|transposase	IS66 family transposase	A0A0P0ZBS5	Stx2-converting_phage	5.0e-258	89.1

DBSCAN-SWA_2

2000745 : 2078340

Escherichia_phage(32.76%)

holin,terminase,head,portal,transposase,integrase,capsid,tRNA,lysis,tail

attL 2001873:2001888|attR 2045188:2045203

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000526135.1\|2000745_2001204_+\|transposase	IS200/IS605 family transposase	NA	NA	NA	NA
WP_001300895.1\|2001325_2002288_-	L,D-transpeptidase LdtC	NA	NA	NA	NA
2001873:2001888	attL	NA	NA	NA	NA
WP_024166502.1\|2002431_2005878_-	transcription-repair coupling factor	NA	NA	NA	NA
WP_001522877.1\|2006005_2007079_-	acyltransferase family protein	NA	NA	NA	NA
WP_000284714.1\|2007339_2008539_+	lipoprotein-releasing ABC transporter permease subunit LolC	NA	NA	NA	NA
WP_001033689.1\|2008531_2009233_+	lipoprotein-releasing ABC transporter ATP-binding protein LolD	G9BWD6	Planktothrix_phage	5.4e-35	39.8
WP_001251363.1\|2009232_2010477_+	lipoprotein-releasing ABC transporter permease subunit LolE	NA	NA	NA	NA
WP_000291248.1\|2010505_2011417_+	N-acetylglucosamine kinase	NA	NA	NA	NA
WP_000952736.1\|2011432_2012254_+	NAD-dependent protein deacylase	A0A2I7S9Y2	Vibrio_phage	5.6e-23	35.6
WP_000720604.1\|2012390_2013176_-	hypothetical protein	NA	NA	NA	NA
WP_001522885.1\|2013172_2013634_-	DUF3592 domain-containing protein	NA	NA	NA	NA
WP_000759309.1\|2013691_2014738_-	spermidine/putrescine ABC transporter substrate-binding protein PotD	NA	NA	NA	NA
WP_000580316.1\|2014734_2015529_-	spermidine/putrescine ABC transporter permease PotC	NA	NA	NA	NA
WP_000074983.1\|2015695_2016814_-\|integrase	tyrosine-type recombinase/integrase	Q77Z04	Phage_21	7.7e-84	44.2
WP_000003742.1\|2016782_2017052_-	excisionase	NA	NA	NA	NA
WP_000102155.1\|2017113_2019570_-	exonuclease	V5UQJ3	Shigella_phage	3.3e-103	42.6
WP_001093951.1\|2019647_2019851_-	DUF1482 family protein	NA	NA	NA	NA
WP_000450218.1\|2019847_2020036_-	cell division inhibitor	NA	NA	NA	NA
WP_000935596.1\|2020046_2020901_-	hypothetical protein	A0A0P0ZE80	Stx2-converting_phage	3.6e-65	63.2
WP_000394557.1\|2021431_2021806_-	hypothetical protein	NA	NA	NA	NA
WP_000379564.1\|2021817_2021970_-	DUF1391 family protein	NA	NA	NA	NA
WP_000787428.1\|2022176_2022584_-	helix-turn-helix domain-containing protein	I6PD69	Cronobacter_phage	9.8e-29	49.6
WP_000912294.1\|2022660_2022888_+	transcriptional regulator	NA	NA	NA	NA
WP_000705383.1\|2022871_2023423_+	hypothetical protein	NA	NA	NA	NA
WP_000020541.1\|2023394_2024435_+	DNA-binding protein	A0A0U2RT81	Escherichia_phage	1.0e-90	87.2
WP_001309414.1\|2024346_2024889_+	hypothetical protein	A0A0U2JGJ0	Escherichia_phage	3.6e-79	90.2
WP_000450706.1\|2024922_2025693_+	DUF1627 domain-containing protein	A0A0U2SAW4	Escherichia_phage	1.1e-86	68.4
WP_001141099.1\|2025708_2026101_+	DUF977 family protein	A0A088CBK9	Shigella_phage	1.5e-39	63.3
WP_001266130.1\|2026097_2026394_+	DUF4406 domain-containing protein	A0A0U2SAZ1	Escherichia_phage	1.2e-47	95.8
WP_001209475.1\|2026390_2026852_+	ead/Ea22-like family protein	Q8VNQ2	Enterobacteria_phage	2.6e-38	94.0
WP_000403791.1\|2026829_2027186_+	hypothetical protein	A0A2R2Z307	Escherichia_phage	1.1e-57	98.3
WP_000137947.1\|2027281_2027689_+	hypothetical protein	A0A0N7KZJ2	Stx2-converting_phage	6.1e-23	60.4
WP_001229301.1\|2027690_2028056_+	HNH endonuclease	A0A2R2Z2X9	Escherichia_phage	1.9e-68	99.2
WP_000208092.1\|2028052_2029039_+	hypothetical protein	Q1MVF7	Enterobacteria_phage	1.8e-44	41.5
WP_001336454.1\|2029120_2029339_+	hypothetical protein	NA	NA	NA	NA
WP_000813254.1\|2029597_2029753_+	type I toxin-antitoxin system toxin HokD	A0A0U2QV81	Escherichia_phage	1.5e-17	96.1
WP_000980989.1\|2029969_2030221_+	hypothetical protein	NA	NA	NA	NA
WP_001309417.1\|2030287_2030566_+	hypothetical protein	I6PCV7	Cronobacter_phage	6.3e-11	45.3
WP_001265256.1\|2030567_2031626_+	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	1.8e-90	48.3
WP_000140038.1\|2031626_2031995_+	RusA family crossover junction endodeoxyribonuclease	V5URS4	Shigella_phage	2.4e-34	62.8
WP_001064909.1\|2031987_2032677_+	antiterminator	I6PDF8	Cronobacter_phage	7.1e-56	48.1
WP_001309418.1\|2032889_2033087_+	hypothetical protein	S5MQK8	Escherichia_phage	1.7e-26	93.8
WP_157835956.1\|2033062_2033176_+	DUF3927 family protein	NA	NA	NA	NA
WP_000871291.1\|2033456_2033792_-	anti-adapter protein IraM	Q8HAJ1	Enterobacteria_phage	5.2e-44	74.8
WP_001309419.1\|2034037_2034241_+	DUF1737 domain-containing protein	H6WZJ9	Escherichia_phage	2.7e-27	96.8
WP_001309421.1\|2034237_2034399_+	hypothetical protein	Q08JA2	Stx2-converting_phage	1.6e-14	89.1
WP_000284506.1\|2034548_2034764_+\|holin	holin	Q9ZWW2	Enterobacteria_phage	6.9e-34	100.0
WP_060578251.1\|2034768_2035659_+	YdfR family protein	Q08JA0	Stx2-converting_phage	3.6e-108	70.6
WP_001092864.1\|2035695_2036229_+	lysozyme	Q6H9V6	Enterobacteria_phage	3.3e-101	96.0
WP_000459345.1\|2036388_2036526_+	hypothetical protein	Q687G2	Enterobacteria_phage	1.3e-17	97.8
WP_001082562.1\|2036527_2036995_+\|lysis	lysis protein	Q7AYI6	Enterobacteria_phage	7.0e-55	77.9
WP_000235436.1\|2037443_2037953_+\|terminase	terminase	A0A1I9KFT4	Aeromonas_phage	1.6e-12	32.7
WP_001309424.1\|2037924_2039853_+\|terminase	phage terminase large subunit family protein	A0A0K2FJ14	Enterobacteria_phage	1.4e-261	66.4
WP_000258993.1\|2039836_2040043_+\|head,tail	head-tail joining protein	K7PM10	Enterobacteria_phage	3.0e-10	55.4
WP_001322425.1\|2040039_2041632_+\|portal	phage portal protein	K7P6U7	Enterobacteria_phage	4.9e-185	61.1
WP_001253887.1\|2041621_2043070_+	S49 family peptidase	A0A2I6TC87	Escherichia_phage	9.9e-100	53.1
WP_000256814.1\|2043106_2043454_+\|head	head decoration protein	A0A2R9YJN3	Escherichia_phage	6.8e-23	59.1
WP_000522603.1\|2043511_2044540_+\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	1.4e-116	62.2
WP_000201530.1\|2044591_2044966_+	hypothetical protein	NA	NA	NA	NA
WP_001204533.1\|2044958_2045312_+\|tail	tail attachment protein	A0A0K2FJB7	Enterobacteria_phage	1.9e-41	70.1
2045188:2045203	attR	NA	NA	NA	NA
WP_000974996.1\|2045327_2045861_+\|tail	phage tail protein	A0A2R9YJK4	Escherichia_phage	2.5e-56	64.6
WP_000683079.1\|2045857_2046253_+\|tail	tail protein	A0A2R9YJI2	Escherichia_phage	1.5e-58	82.4
WP_000235048.1\|2046260_2047010_+\|tail	phage tail protein	Q687F6	Enterobacteria_phage	2.7e-125	93.8
WP_001309426.1\|2047028_2047460_+\|tail	phage minor tail protein G	A0A0K2FIQ8	Enterobacteria_phage	7.4e-43	68.8
WP_000533401.1\|2047486_2047900_+\|tail	phage tail assembly protein T	S5MDP5	Escherichia_phage	4.6e-42	82.8
WP_000082417.1\|2047880_2050442_+\|tail	phage tail tape measure protein	A0A2R9YJM8	Escherichia_phage	0.0e+00	87.5
WP_000847291.1\|2050438_2050768_+\|tail	phage tail protein	Q687F2	Enterobacteria_phage	2.1e-58	99.1
WP_001309428.1\|2050767_2051466_+\|tail	phage minor tail protein L	H6WZM3	Escherichia_phage	3.2e-128	96.6
WP_000194723.1\|2051476_2052220_+\|tail	phage tail protein	Q6H9T4	Enterobacteria_phage	5.0e-148	98.0
WP_122991350.1\|2052165_2052798_+\|tail	tail assembly protein	A0A0P0ZC16	Stx2-converting_phage	1.2e-102	96.7
WP_000514742.1\|2053141_2056834_+	DUF1983 domain-containing protein	A0A0P0ZCI5	Stx2-converting_phage	0.0e+00	85.7
WP_001233148.1\|2056901_2057501_+	Ail/Lom family protein	H6WZM8	Escherichia_phage	7.7e-107	94.0
WP_000216486.1\|2057652_2060679_+	membrane protein	A0A0K2FIZ6	Escherichia_phage	1.4e-55	54.6
WP_000885577.1\|2060678_2061263_+\|tail	tail fiber assembly protein	K7PMH7	Enterobacteria_phage	6.6e-103	94.8
WP_000240999.1\|2061317_2061986_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000937481.1\|2062042_2062309_+\|tail	tail fiber assembly protein	K7PMH7	Enterobacteria_phage	1.5e-17	81.8
WP_000799406.1\|2062540_2063404_-	spermidine/putrescine ABC transporter permease PotB	Q6GZ02	Mycoplasma_phage	6.7e-11	28.7
WP_000531594.1\|2063387_2064524_-	spermidine/putrescine ABC transporter ATP-binding protein PotA	Q6GZ03	Mycoplasma_phage	5.5e-29	39.8
WP_001522887.1\|2064773_2066000_+	peptidase T	NA	NA	NA	NA
WP_000456506.1\|2066048_2067170_-	[50S ribosomal protein L16]-arginine 3-hydroxylase	NA	NA	NA	NA
WP_000735412.1\|2067245_2068706_-	two-component system sensor histidine kinase PhoQ	NA	NA	NA	NA
WP_001265481.1\|2068705_2069377_-	two-component system response regulator PhoP	NA	NA	NA	NA
WP_000423742.1\|2069546_2070917_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	1.2e-107	44.9
WP_001297479.1\|2070920_2071562_-	high frequency lysogenization protein HflD	NA	NA	NA	NA
WP_000004751.1\|2071597_2072704_-\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_105375189.1\|2072757_2073219_-	phosphatase NudJ	NA	NA	NA	NA
WP_000873387.1\|2073228_2073867_-	23S rRNA pseudouridine(2457) synthase RluE	NA	NA	NA	NA
WP_012602377.1\|2074199_2074550_-	DUF1493 family protein	NA	NA	NA	NA
WP_000381622.1\|2074534_2074984_-	hypothetical protein	NA	NA	NA	NA
WP_001522898.1\|2075566_2076817_+	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	6.5e-23	98.1
WP_020232865.1\|2076919_2077243_-	anti-adapter protein IraM	Q20GJ2	Phage_258-320	6.3e-39	62.6
WP_000526135.1\|2077881_2078340_+\|transposase	IS200/IS605 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2295307 : 2353499

Escherichia_phage(49.09%)

holin,terminase,integrase,tRNA,lysis,tail

attL 2286203:2286218|attR 2329187:2329202

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2286203:2286218	attL	NA	NA	NA	NA
WP_100190652.1\|2295307_2296255_-	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	2.4e-17	39.5
WP_000387388.1\|2297571_2298555_+	zinc transporter ZntB	NA	NA	NA	NA
WP_000123748.1\|2299032_2300406_+	ATP-dependent RNA helicase DbpA	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	6.6e-53	33.1
WP_001523172.1\|2300534_2301470_-\|tRNA	tRNA 2-thiocytidine(32) synthetase TtcA	A0A0U2S5Z2	Escherichia_phage	5.9e-146	98.8
WP_000040839.1\|2301521_2302757_-\|integrase	site-specific integrase	A0A0U2JGI6	Escherichia_phage	3.8e-241	99.5
WP_000079604.1\|2302758_2302974_-	excisionase XisR	A0A0U2RY08	Escherichia_phage	1.8e-37	100.0
WP_001302840.1\|2303073_2303262_-	DUF1187 family protein	A0A0U2QL97	Escherichia_phage	5.5e-27	98.4
WP_001443846.1\|2303299_2303449_-	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	A0A0U2QQP4	Escherichia_phage	2.5e-22	95.9
WP_000166313.1\|2303504_2304314_-	recombination protein RecT	A0A1P8DTF2	Proteus_phage	4.0e-106	71.5
WP_000105140.1\|2304306_2306907_-	exodeoxyribonuclease VIII	A0A0U2I1R6	Escherichia_phage	6.1e-249	63.5
WP_001344816.1\|2307008_2307284_-	hypothetical protein	A0A0U2QW85	Escherichia_phage	4.0e-42	95.6
WP_001352098.1\|2307358_2307529_-	conserved protein, Rac prophage	A0A0U2SHB5	Escherichia_phage	3.6e-17	71.4
WP_000560223.1\|2307528_2307750_-	killing protein KilR	A0A0U2RTC4	Escherichia_phage	2.0e-36	98.6
WP_001312793.1\|2308191_2308680_+	superinfection exclusion protein B	NA	NA	NA	NA
WP_001169151.1\|2308676_2308832_-	YdaF family protein	M4QQ57	Salicola_phage	6.1e-08	55.3
WP_001326317.1\|2308842_2309022_-	hypothetical protein	NA	NA	NA	NA
WP_000233319.1\|2309264_2309684_-	helix-turn-helix domain-containing protein	A0A2I6PIE7	Escherichia_phage	5.5e-19	46.5
WP_001072342.1\|2309763_2310018_+	hypothetical protein	A0A2I6PIE5	Escherichia_phage	1.3e-18	61.6
WP_000693803.1\|2310014_2310437_+	hypothetical protein	A0A0U2RXZ9	Escherichia_phage	1.3e-68	92.9
WP_001396581.1\|2310514_2311303_+	hypothetical protein	G9L6A8	Escherichia_phage	2.0e-41	64.3
WP_020233967.1\|2311309_2312056_+	ATP-binding protein	V5UQI5	Shigella_phage	1.1e-110	78.5
WP_123876605.1\|2312078_2312840_+	DUF1627 domain-containing protein	A0A0U2SAW4	Escherichia_phage	1.7e-114	87.0
WP_029702111.1\|2312855_2313278_+	DUF977 family protein	A0A0U2QQN3	Escherichia_phage	7.4e-64	90.6
WP_000137958.1\|2313439_2313943_+	hypothetical protein	Q9G078	Enterobacteria_phage	4.3e-18	39.7
WP_000200358.1\|2314063_2314837_-	KilA-N domain-containing protein	A0A1L2BWW1	Bacteriophage	9.6e-09	42.6
WP_001445775.1\|2315359_2315485_+	Hok/Gef family protein	A0A0U2QV81	Escherichia_phage	4.0e-10	90.2
WP_001445776.1\|2315567_2315909_-	DUF1971 domain-containing protein	NA	NA	NA	NA
WP_000940344.1\|2316776_2317376_+	DUF1367 family protein	A0A0U2RT94	Escherichia_phage	2.9e-106	92.0
WP_000228032.1\|2317375_2317666_+	DUF1364 domain-containing protein	A0A0U2KD41	Escherichia_phage	7.4e-47	88.5
WP_000640106.1\|2317662_2318205_+	DUF1133 family protein	A0A0U2S606	Escherichia_phage	5.8e-77	76.3
WP_001208722.1\|2318426_2318996_+	hypothetical protein	NA	NA	NA	NA
WP_001328752.1\|2318964_2319267_-	hypothetical protein	NA	NA	NA	NA
WP_000781775.1\|2319343_2319685_+\|holin	phage holin, lambda family	Q8SBE1	Shigella_phage	6.2e-53	90.1
WP_023153991.1\|2319688_2320165_+	glycoside hydrolase family protein	K7PKV2	Enterobacteria_phage	5.0e-85	95.6
WP_001228696.1\|2320381_2320567_+\|lysis	prophage lysis lipoprotein RzoD	K7PHU6	Enterobacteria_phage	2.8e-15	98.2
WP_001097895.1\|2320763_2322221_+	Trk system potassium uptake protein TrkG	NA	NA	NA	NA
WP_001291105.1\|2322358_2323150_+	ParB N-terminal domain-containing protein	R4TG31	Halovirus	2.8e-48	40.2
WP_020233805.1\|2323142_2324075_+	hypothetical protein	A0A1B1INP7	uncultured_Mediterranean_phage	1.1e-83	54.9
WP_000126788.1\|2324052_2324262_+	hypothetical protein	NA	NA	NA	NA
WP_000089448.1\|2324265_2325360_+	hypothetical protein	A0A0U2RXW9	Escherichia_phage	4.5e-113	80.5
WP_000625348.1\|2325340_2326642_+\|terminase	terminase	A0A1B1P9C9	Acinetobacter_phage	3.6e-149	59.6
WP_000763701.1\|2326644_2328051_+	DUF4055 domain-containing protein	G8C7P4	Escherichia_phage	3.0e-186	69.0
WP_001363932.1\|2328034_2329147_+	hypothetical protein	I6PD76	Cronobacter_phage	7.1e-114	54.5
WP_000770042.1\|2329251_2330016_+	hypothetical protein	G8C7P6	Escherichia_phage	6.9e-84	64.2
2329187:2329202	attR	NA	NA	NA	NA
WP_020233804.1\|2330114_2331254_+	hypothetical protein	G8C7P7	Escherichia_phage	9.7e-159	75.0
WP_000908084.1\|2331296_2331473_+	hypothetical protein	G8C7P8	Escherichia_phage	4.7e-12	62.3
WP_057950804.1\|2331476_2331872_+	hypothetical protein	NA	NA	NA	NA
WP_000524260.1\|2331871_2332255_+	hypothetical protein	A0A0P0I456	Acinetobacter_phage	2.2e-14	39.4
WP_042002565.1\|2332255_2332636_+	hypothetical protein	A0A059VF88	Pseudomonas_phage	1.5e-18	43.6
WP_000673077.1\|2332632_2333025_+	hypothetical protein	NA	NA	NA	NA
WP_001328756.1\|2333051_2334014_+	hypothetical protein	A0A059VG08	Pseudomonas_phage	8.4e-55	38.6
WP_122452218.1\|2334164_2334524_+	hypothetical protein	NA	NA	NA	NA
WP_032139919.1\|2334631_2334832_+	hypothetical protein	NA	NA	NA	NA
WP_023153989.1\|2334995_2338229_+\|tail	phage tail tape measure protein	A0A2H4J9A1	uncultured_Caudovirales_phage	7.4e-103	33.0
WP_000024051.1\|2338221_2338560_+\|tail	phage tail protein	H6WZM2	Escherichia_phage	4.0e-28	50.0
WP_001152432.1\|2338559_2339258_+\|tail	phage minor tail protein L	A0A0K2FJ01	Enterobacteria_phage	1.1e-125	93.5
WP_001351716.1\|2339263_2340007_+\|tail	phage tail protein	K7PLW1	Enterobacteria_phage	1.0e-145	96.7
WP_049286672.1\|2339943_2340546_+\|tail	tail assembly protein	A5LH42	Enterobacteria_phage	8.1e-88	85.6
WP_021523093.1\|2340606_2344086_+	host specificity protein J	A5LH43	Enterobacteria_phage	0.0e+00	89.6
WP_001542091.1\|2344153_2344753_+	Ail/Lom family outer membrane beta-barrel protein	Q9EV15	Enterobacteria_phage	9.8e-102	91.5
WP_032152843.1\|2344817_2347217_+\|tail	phage tail protein	A0A0E3M194	Enterobacteria_phage	3.9e-133	55.3
WP_000654154.1\|2347213_2347495_+	hypothetical protein	A0A1X7QHA1	Escherichia_phage	1.2e-17	47.8
WP_000235967.1\|2347504_2348209_+\|tail	tail fiber domain-containing protein	A0A1X7QGH6	Escherichia_phage	1.2e-58	61.7
WP_000355609.1\|2348219_2348513_+	hypothetical protein	NA	NA	NA	NA
WP_000086527.1\|2348740_2349331_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	1.6e-24	38.8
WP_000836768.1\|2349647_2349881_-	cold shock protein YdfK	A0A192Y6D5	Salmonella_phage	1.1e-32	88.3
WP_120795384.1\|2349949_2350063_-	Rac prophage; protein YnaM	A0A1C9IHU6	Salmonella_phage	8.4e-07	80.6
WP_001523332.1\|2350666_2351950_+	MHS family MFS transporter	NA	NA	NA	NA
WP_000527786.1\|2352038_2353499_+	mannitol dehydrogenase family protein	G8DCZ3	Micromonas_pusilla_virus	5.1e-43	29.7

DBSCAN-SWA_4

2502100 : 2612529

115

Enterobacteria_phage(42.59%)

terminase,head,portal,transposase,capsid,integrase,tail,lysis

attL 2557317:2557332|attR 2606531:2606546

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000526135.1\|2502100_2502559_-\|transposase	IS200/IS605 family transposase	NA	NA	NA	NA
WP_001261003.1\|2502736_2503405_-	DUF3313 domain-containing protein	NA	NA	NA	NA
WP_000586719.1\|2503707_2504301_-	tellurite resistance methyltransferase TehB	NA	NA	NA	NA
WP_001296725.1\|2504297_2505290_-	dicarboxylate transporter/tellurite-resistance protein TehA	NA	NA	NA	NA
WP_042002675.1\|2505413_2506394_+	LbetaH domain-containing protein	NA	NA	NA	NA
WP_057950846.1\|2506385_2506925_-	50S ribosomal protein L7/L12-serine acetyltransferase	NA	NA	NA	NA
WP_001296778.1\|2506987_2507212_-	YdcH family protein	NA	NA	NA	NA
WP_048265110.1\|2507351_2509007_-	glucan biosynthesis protein OpgD	NA	NA	NA	NA
WP_001523218.1\|2509231_2510575_-	VOC family protein	NA	NA	NA	NA
WP_000414564.1\|2510791_2511715_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_001523216.1\|2511752_2513393_-	methyl-accepting chemotaxis protein Trg	NA	NA	NA	NA
WP_001309484.1\|2513791_2513941_+	type I toxin-antitoxin system toxin HokB	NA	NA	NA	NA
WP_000731851.1\|2514012_2514186_-	hypothetical protein	A0A0R6PI25	Moraxella_phage	4.4e-07	59.6
WP_001390056.1\|2514430_2514961_-	cytochrome b561	A0A0U2QLA7	Escherichia_phage	2.0e-18	43.9
WP_000048645.1\|2515149_2516151_+	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000115969.1\|2516192_2517632_-	aldehyde dehydrogenase	NA	NA	NA	NA
WP_001027943.1\|2517828_2518629_-	YdcF family protein	NA	NA	NA	NA
WP_000343026.1\|2518744_2519122_-	hypothetical protein	NA	NA	NA	NA
WP_001314706.1\|2519241_2519691_-	hypothetical protein	NA	NA	NA	NA
WP_001523214.1\|2519677_2520016_-	hypothetical protein	NA	NA	NA	NA
WP_021517100.1\|2520300_2524203_-	ATP-dependent RNA helicase HrpA	A0A1V0SIV3	Klosneuvirus	2.2e-53	29.5
WP_000048963.1\|2524403_2525009_+	FMN-dependent NADH-azoreductase	NA	NA	NA	NA
WP_020233384.1\|2525062_2526379_-	phosphatase PAP2/dual specificity phosphatase family protein	NA	NA	NA	NA
WP_021523075.1\|2526368_2528126_-	bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000177498.1\|2529037_2529643_-	CDP-alcohol phosphatidyltransferase family protein	NA	NA	NA	NA
WP_001523206.1\|2529813_2532120_-	DUF2773 domain-containing bactofilin	NA	NA	NA	NA
WP_021523074.1\|2532183_2533044_-	pyridoxine 4-dehydrogenase	NA	NA	NA	NA
WP_059321765.1\|2533251_2535660_-	autotransporter outer membrane beta-barrel domain-containing protein	NA	NA	NA	NA
WP_001523200.1\|2539733_2540057_-	YdbL family protein	NA	NA	NA	NA
WP_000698145.1\|2540064_2540250_-	YnbE family lipoprotein	NA	NA	NA	NA
WP_023153685.1\|2540246_2542886_-	YdbH family protein	NA	NA	NA	NA
WP_000762229.1\|2543093_2544083_+	D-lactate dehydrogenase	M1I4S0	Paramecium_bursaria_Chlorella_virus	2.5e-70	44.0
WP_001523197.1\|2544193_2544616_+	heat shock protein HslJ	NA	NA	NA	NA
WP_001295715.1\|2544612_2544879_-	DUF333 domain-containing protein	NA	NA	NA	NA
WP_021517097.1\|2545152_2548677_+	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
WP_000837924.1\|2549043_2550177_+	porin OmpN	Q1MVN1	Enterobacteria_phage	8.3e-118	58.8
WP_057950810.1\|2550317_2550752_+	universal stress protein UspF	A0A1W6JNV4	Morganella_phage	3.0e-28	52.8
WP_113328759.1\|2551360_2552251_+	iron/manganese ABC transporter substrate-binding protein SitA	NA	NA	NA	NA
WP_000983718.1\|2552250_2553078_+	iron/manganese ABC transporter ATP-binding protein SitB	G9BWD6	Planktothrix_phage	3.8e-11	28.5
WP_001101728.1\|2553074_2553932_+	iron/manganese ABC transporter permease subunit SitC	NA	NA	NA	NA
WP_000968125.1\|2553928_2554786_+	iron/manganese ABC transporter permease subunit SitD	NA	NA	NA	NA
WP_000354607.1\|2555258_2556053_+	hypothetical protein	NA	NA	NA	NA
WP_001405873.1\|2556598_2556892_-	hypothetical protein	NA	NA	NA	NA
WP_001314683.1\|2556934_2557975_-\|tail	tail fiber domain-containing protein	A0A0E3M4A9	Enterobacteria_phage	2.9e-125	67.9
2557317:2557332	attL	NA	NA	NA	NA
WP_000654155.1\|2557984_2558266_-	hypothetical protein	A0A1X7QHA1	Escherichia_phage	1.4e-18	50.0
WP_042099016.1\|2558265_2560641_-\|tail	phage tail protein	A0A1X7QGG5	Escherichia_phage	1.8e-167	69.0
WP_000526135.1\|2560761_2561220_-\|transposase	IS200/IS605 family transposase	NA	NA	NA	NA
WP_001542091.1\|2561416_2562016_-	Ail/Lom family outer membrane beta-barrel protein	Q9EV15	Enterobacteria_phage	9.8e-102	91.5
WP_021523093.1\|2562083_2565563_-	host specificity protein J	A5LH43	Enterobacteria_phage	0.0e+00	89.6
WP_049286672.1\|2565623_2566226_-\|tail	tail assembly protein	A5LH42	Enterobacteria_phage	8.1e-88	85.6
WP_032153655.1\|2566162_2566906_-\|tail	phage tail protein	K7PLW1	Enterobacteria_phage	9.5e-147	96.7
WP_001551186.1\|2566911_2567610_-\|tail	phage minor tail protein L	A0A0K2FJ01	Enterobacteria_phage	8.9e-131	97.4
WP_000847345.1\|2567609_2567939_-\|tail	phage tail protein	A0A0K2FIE9	Enterobacteria_phage	8.1e-58	98.2
WP_032153656.1\|2567935_2570497_-\|tail	phage tail tape measure protein	A0A0K2FI43	Enterobacteria_phage	0.0e+00	95.9
WP_000459457.1\|2570489_2570924_-\|tail	phage tail assembly protein T	A0A0K2FJB3	Enterobacteria_phage	6.9e-65	100.0
WP_000479153.1\|2570905_2571328_-\|tail	phage minor tail protein G	A0A0K2FIQ8	Enterobacteria_phage	6.7e-73	100.0
WP_001349920.1\|2571343_2572084_-\|tail	phage tail protein	A0A0K2FJ05	Enterobacteria_phage	7.8e-133	100.0
WP_000683128.1\|2572091_2572487_-\|tail	tail protein	A0A2R9YJI2	Escherichia_phage	6.5e-70	99.2
WP_000752979.1\|2573074_2573428_-\|tail	tail attachment protein	A0A0K2FJB7	Enterobacteria_phage	2.0e-62	100.0
WP_020233914.1\|2573439_2573838_-	DNA-packaging protein FI	A0A0K2FIR1	Enterobacteria_phage	2.3e-62	98.5
WP_000063277.1\|2573879_2574905_-\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	2.7e-192	99.7
WP_001708751.1\|2574959_2575292_-\|head	head decoration protein	A0A2R9YJN3	Escherichia_phage	3.8e-55	99.1
WP_020233915.1\|2575301_2576621_-	S49 family peptidase	A0A2I6TC87	Escherichia_phage	2.2e-231	97.7
WP_001356819.1\|2576601_2578203_-\|portal	phage portal protein	A0A0K2FJC0	Enterobacteria_phage	1.1e-309	99.2
WP_000198149.1\|2578199_2578406_-\|head,tail	Lambda prophage-derived head-to-tail joining protein W	A0A2R9YJL2	Escherichia_phage	5.8e-30	100.0
WP_001027269.1\|2578402_2580328_-\|terminase	phage terminase large subunit family protein	A0A0K2FJ14	Enterobacteria_phage	0.0e+00	99.5
WP_000453587.1\|2580302_2580848_-	DNA-packaging protein	A0A0K2FIG2	Enterobacteria_phage	1.4e-94	98.9
WP_001368374.1\|2581236_2581470_+	YlcI/YnfO family protein	A0A0K2FIR8	Escherichia_phage	2.5e-21	84.1
WP_000373090.1\|2581527_2581938_+	DUF1398 domain-containing protein	C6ZCX4	Enterobacteria_phage	2.5e-56	79.4
WP_001019606.1\|2582089_2582263_-	addiction module toxin, GnsA/GnsB family	NA	NA	NA	NA
WP_001309517.1\|2582434_2582590_-	hypothetical protein	NA	NA	NA	NA
WP_120795388.1\|2582669_2582735_-	Qin prophage; protein YnfR	NA	NA	NA	NA
WP_071524604.1\|2582737_2582926_-	cold-shock protein	NA	NA	NA	NA
WP_000066495.1\|2582936_2583149_-	cold shock protein CspI	A0A1W6JNX5	Morganella_phage	1.2e-22	74.3
WP_001071769.1\|2583511_2584009_-	DUF2514 domain-containing protein	A0A291LBG9	Klebsiella_phage	2.9e-06	29.5
WP_001092971.1\|2584005_2584539_-	lysozyme	K7PLY1	Enterobacteria_phage	6.4e-97	93.2
WP_000189916.1\|2584535_2584847_-	YdfR family protein	K7PGU6	Enterobacteria_phage	2.0e-26	64.6
WP_000839590.1\|2584851_2585067_-\|lysis	phage lysis protein EssD	A5LH82	Enterobacteria_phage	1.1e-31	94.4
WP_000066484.1\|2585820_2586036_-	cold shock-like protein CspB	A0A1W6JNX5	Morganella_phage	3.4e-25	76.5
WP_000087756.1\|2586336_2586549_+	cold shock-like protein CspF	NA	NA	NA	NA
WP_120795389.1\|2586603_2586693_+	Qin prophage; protein YnfS	NA	NA	NA	NA
WP_001047135.1\|2586970_2587723_-	antitermination protein	A0A192Y5X6	Salmonella_phage	7.1e-134	92.8
WP_001265199.1\|2587736_2588786_-	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	2.8e-112	57.0
WP_012304870.1\|2588787_2589066_-	hypothetical protein	NA	NA	NA	NA
WP_000980994.1\|2589132_2589384_-	hypothetical protein	NA	NA	NA	NA
WP_000813254.1\|2589600_2589756_-	type I toxin-antitoxin system toxin HokD	A0A0U2QV81	Escherichia_phage	1.5e-17	96.1
WP_000323025.1\|2589827_2590115_-	type II toxin-antitoxin system mRNA interferase RelE	A0A2H4JBF4	uncultured_Caudovirales_phage	1.4e-29	66.0
WP_000534858.1\|2590114_2590354_-	type II toxin-antitoxin system antitoxin RelB	A0A2H4JBG1	uncultured_Caudovirales_phage	1.6e-18	54.4
WP_001326990.1\|2590378_2590684_+	hypothetical protein	NA	NA	NA	NA
WP_001301033.1\|2590886_2591219_+	protein FlxA	NA	NA	NA	NA
WP_000589005.1\|2591655_2592969_-\|transposase	ISNCY family transposase	NA	NA	NA	NA
WP_000915483.1\|2593452_2594475_-	DUF4868 domain-containing protein	NA	NA	NA	NA
WP_001265627.1\|2594477_2595092_-	hypothetical protein	NA	NA	NA	NA
WP_021523102.1\|2595300_2595966_-	epoxyqueuosine reductase QueH	NA	NA	NA	NA
WP_001151242.1\|2596168_2596567_-	DUF977 family protein	A0A0U2QQN3	Escherichia_phage	7.7e-63	93.9
WP_000054487.1\|2596607_2597573_-	hypothetical protein	U5P0A0	Shigella_phage	2.6e-56	60.8
WP_000705355.1\|2597553_2598075_-	hypothetical protein	NA	NA	NA	NA
WP_000921596.1\|2598058_2598286_-	transcriptional regulator	NA	NA	NA	NA
WP_000381212.1\|2598366_2598774_+	helix-turn-helix domain-containing protein	I6PD69	Cronobacter_phage	7.2e-32	51.9
WP_000379575.1\|2598942_2599098_+	DUF1391 family protein	M4QQ57	Salicola_phage	3.0e-07	53.2
WP_000344950.1\|2599099_2599675_+	hypothetical protein	NA	NA	NA	NA
WP_000854559.1\|2600161_2600350_+	cell division inhibition protein DicB	NA	NA	NA	NA
WP_001083276.1\|2600346_2600538_+\|lysis	lysis protein YdfD	NA	NA	NA	NA
WP_000048363.1\|2600631_2603103_+	exonuclease	A0A192Y6E0	Salmonella_phage	1.2e-57	56.1
WP_000005552.1\|2603175_2603427_+	excisionase family protein	S4TND0	Salmonella_phage	2.2e-15	50.0
WP_021523105.1\|2603461_2604742_+\|integrase	site-specific integrase	B6DZ48	Enterobacteria_phage	3.9e-156	62.6
WP_001389342.1\|2604743_2604872_-	hypothetical protein	NA	NA	NA	NA
WP_000836037.1\|2604929_2605949_-	Zn-dependent oxidoreductase	E3SJ82	Synechococcus_phage	4.3e-17	26.2
WP_001295394.1\|2605960_2607175_-	starvation-sensing protein RspA	Q6A202	Oenococcus_phage	1.4e-46	29.0
2606531:2606546	attR	NA	NA	NA	NA
WP_001314753.1\|2607380_2607707_-	YnfA family protein	A0A218MNG8	uncultured_virus	2.2e-23	54.5
WP_000705205.1\|2607841_2608183_+	DUF1283 family protein	NA	NA	NA	NA
WP_001138584.1\|2608217_2608778_+	spermidine N1-acetyltransferase	NA	NA	NA	NA
WP_001445899.1\|2608780_2609491_-	YnfC family lipoprotein	NA	NA	NA	NA
WP_001295396.1\|2609598_2609904_+	DUF1161 domain-containing protein	NA	NA	NA	NA
WP_001551145.1\|2610102_2612529_+	dimethyl sulfoxide reductase subunit A	A0A077SK27	Escherichia_phage	1.7e-213	49.2

DBSCAN-SWA_5

2862239 : 2960625

108

Enterobacteria_phage(47.06%)

holin,terminase,head,protease,portal,capsid,integrase,tRNA,tail,lysis

attL 2939222:2939237|attR 2958886:2958901

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000984502.1\|2862239_2863121_-\|protease	protease HtpX	NA	NA	NA	NA
WP_057950751.1\|2863312_2865361_-	carboxy terminal-processing peptidase	A0A0R6PIZ1	Moraxella_phage	3.0e-86	33.5
WP_000431370.1\|2865380_2866079_-	RNA chaperone ProQ	NA	NA	NA	NA
WP_001043882.1\|2866175_2866673_-	L-methionine (R)-S-oxide reductase	NA	NA	NA	NA
WP_001520702.1\|2866802_2868086_+	membrane integrity lipid transport subunit YebS	NA	NA	NA	NA
WP_001306757.1\|2868054_2870688_+	lipid-binding membrane homeostasis protein YebT	NA	NA	NA	NA
WP_024166480.1\|2870767_2872207_+	16S rRNA (cytosine(1407)-C(5))-methyltransferase RsmF	NA	NA	NA	NA
WP_001295499.1\|2872324_2872561_+	DUF1480 family protein	NA	NA	NA	NA
WP_000929530.1\|2872581_2872857_+	YebW family protein	NA	NA	NA	NA
WP_001520704.1\|2872857_2873514_-	protein-serine/threonine phosphatase	A0A222YWF0	Escherichia_phage	2.8e-57	50.7
WP_001520705.1\|2873909_2874251_-	YebY family protein	NA	NA	NA	NA
WP_000879330.1\|2874263_2875136_-	copper homeostasis membrane protein CopD	NA	NA	NA	NA
WP_000204705.1\|2875139_2875514_-	CopC domain-containing protein YobA	NA	NA	NA	NA
WP_000916763.1\|2875652_2875883_+	DNA polymerase III subunit theta	H9C187	Pectobacterium_phage	1.3e-14	61.8
WP_105375192.1\|2875984_2876641_+	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_000944256.1\|2876664_2877327_+	exodeoxyribonuclease X	Q6UAU3	Klebsiella_phage	2.0e-07	41.6
WP_020233070.1\|2877323_2879384_-	oligopeptidase B	NA	NA	NA	NA
WP_001520710.1\|2879592_2880252_-	tellurite resistance TerB family protein	NA	NA	NA	NA
WP_001295500.1\|2880578_2880935_-	protein YebF	NA	NA	NA	NA
WP_000257738.1\|2881001_2881292_-	DNA damage-inducible protein YebG	NA	NA	NA	NA
WP_021517157.1\|2881425_2882604_+	formate-dependent phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_000800512.1\|2882658_2883300_-	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	NA	NA	NA	NA
WP_001069467.1\|2883336_2885148_-	phosphogluconate dehydratase	NA	NA	NA	NA
WP_000301727.1\|2885382_2886858_-	glucose-6-phosphate dehydrogenase	H6WFS4	Cyanophage	4.4e-79	37.5
WP_001056694.1\|2887195_2888065_+	DNA-binding transcriptional regulator HexR	NA	NA	NA	NA
WP_000091148.1\|2888192_2889635_+	pyruvate kinase	NA	NA	NA	NA
WP_000448381.1\|2889766_2890738_-	lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase	NA	NA	NA	NA
WP_001184045.1\|2890856_2892179_-	murein DD-endopeptidase MepM	A8ATH6	Listeria_phage	1.2e-14	40.9
WP_011076428.1\|2892194_2893127_-	zinc ABC transporter substrate-binding protein ZnuA	NA	NA	NA	NA
WP_000202987.1\|2893205_2893961_+	zinc ABC transporter ATP-binding protein ZnuC	G3M9Y6	Bacillus_virus	1.3e-18	28.3
WP_001520716.1\|2893957_2894743_+	zinc ABC transporter permease subunit ZnuB	NA	NA	NA	NA
WP_000568522.1\|2894892_2895903_-	Holliday junction branch migration DNA helicase RuvB	A0A127AWE7	Bacillus_phage	5.6e-09	25.5
WP_000580323.1\|2895911_2896523_-	Holliday junction branch migration protein RuvA	NA	NA	NA	NA
WP_072146566.1\|2896661_2896727_-	hypothetical protein	NA	NA	NA	NA
WP_001520719.1\|2896797_2897400_+	YebB family permuted papain-like enzyme	NA	NA	NA	NA
WP_001295503.1\|2897401_2897923_-	crossover junction endodeoxyribonuclease RuvC	G3MA90	Bacillus_virus	2.0e-10	35.1
WP_000907234.1\|2897957_2898698_-	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_001308712.1\|2898726_2899179_-	dihydroneopterin triphosphate diphosphatase	NA	NA	NA	NA
WP_001258662.1\|2899296_2901069_-\|tRNA	aspartate--tRNA ligase	NA	NA	NA	NA
WP_000891630.1\|2901378_2901945_+	hydrolase	NA	NA	NA	NA
WP_001217553.1\|2902299_2902548_+	DinI family protein	K7PLW4	Enterobacteria_phage	1.8e-38	100.0
WP_000885577.1\|2902663_2903248_-\|tail	tail fiber assembly protein	K7PMH7	Enterobacteria_phage	6.6e-103	94.8
WP_000216487.1\|2903247_2906274_-	membrane protein	A0A0K2FIZ6	Escherichia_phage	7.0e-55	54.5
WP_001228316.1\|2906425_2907025_-	Ail/Lom family outer membrane beta-barrel protein	Q9EV15	Enterobacteria_phage	2.0e-107	96.5
WP_105375193.1\|2907092_2910566_-	host specificity protein J	A0A0P0ZBW1	Stx2-converting_phage	0.0e+00	89.5
WP_032300536.1\|2910909_2911542_-\|tail	tail assembly protein	Q9EYE5	Enterobacteria_phage	4.2e-103	91.8
WP_001542192.1\|2911487_2912231_-\|tail	phage tail protein	Q6H9T4	Enterobacteria_phage	2.1e-146	97.2
WP_001335877.1\|2912241_2912940_-\|tail	phage minor tail protein L	B6DZB1	Enterobacteria_phage	1.7e-129	96.6
WP_000847298.1\|2912939_2913269_-\|tail	phage tail protein	Q687F2	Enterobacteria_phage	4.3e-59	100.0
WP_001542191.1\|2913265_2915839_-\|tail	phage tail tape measure protein	A0A2R9YJM8	Escherichia_phage	0.0e+00	83.3
WP_000533402.1\|2915819_2916233_-\|tail	phage tail assembly protein T	S5MDP5	Escherichia_phage	1.6e-42	82.2
WP_001542190.1\|2916259_2916691_-\|tail	phage minor tail protein G	A0A0K2FIQ8	Enterobacteria_phage	4.8e-42	68.8
WP_000235110.1\|2916704_2917457_-\|tail	phage tail protein	Q687F6	Enterobacteria_phage	1.2e-133	98.4
WP_000683079.1\|2917464_2917860_-\|tail	tail protein	A0A2R9YJI2	Escherichia_phage	1.5e-58	82.4
WP_000975010.1\|2917856_2918432_-\|tail	tail protein	A0A2R9YJK4	Escherichia_phage	6.4e-50	57.8
WP_000752997.1\|2918447_2918801_-\|tail	tail attachment protein	A0A2R9YJJ5	Escherichia_phage	4.9e-61	97.4
WP_000158858.1\|2918812_2919199_-	hypothetical protein	A0A2R9YJP4	Escherichia_phage	1.2e-52	90.2
WP_000063261.1\|2919240_2920266_-\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	2.5e-190	98.5
WP_001299443.1\|2920322_2920655_-\|head	head decoration protein	A0A2R9YJN3	Escherichia_phage	1.7e-55	100.0
WP_016248240.1\|2920664_2921984_-	S49 family peptidase	A0A2I6TC87	Escherichia_phage	2.8e-234	98.9
WP_016248239.1\|2921964_2923566_-\|portal	phage portal protein	A0A0K2FJC0	Enterobacteria_phage	7.2e-309	98.9
WP_000198149.1\|2923562_2923769_-\|head,tail	Lambda prophage-derived head-to-tail joining protein W	A0A2R9YJL2	Escherichia_phage	5.8e-30	100.0
WP_016248238.1\|2923765_2925691_-\|terminase	phage terminase large subunit family protein	A0A0K2FJ14	Enterobacteria_phage	0.0e+00	98.4
WP_000867489.1\|2925665_2926211_-\|terminase	terminase small subunit	A0A0K2FIG2	Enterobacteria_phage	1.2e-79	83.3
WP_001082562.1\|2926652_2927120_-\|lysis	lysis protein	Q7AYI6	Enterobacteria_phage	7.0e-55	77.9
WP_000459345.1\|2927121_2927259_-	hypothetical protein	Q687G2	Enterobacteria_phage	1.3e-17	97.8
WP_024239084.1\|2927418_2927952_-	lysozyme	Q6H9V6	Enterobacteria_phage	7.4e-101	96.0
WP_000731267.1\|2928002_2928347_-	YdfR family protein	A0A0P0ZD64	Stx2-converting_phage	7.2e-57	97.4
WP_000284510.1\|2928351_2928567_-\|holin	holin	G9L6J5	Escherichia_phage	9.0e-34	100.0
WP_000874341.1\|2928717_2930571_-	SASA family carbohydrate esterase	H6WZJ9	Escherichia_phage	0.0e+00	91.1
WP_021519715.1\|2931359_2932409_-	site-specific DNA-methyltransferase	S5MDR0	Escherichia_phage	3.1e-188	91.4
WP_001420470.1\|2932558_2932756_-	hypothetical protein	Q9MC00	Enterobacteria_phage	6.1e-29	98.5
WP_021553036.1\|2932918_2933716_-	hypothetical protein	A0A0M4R2T6	Salmonella_phage	3.4e-25	32.3
WP_001127354.1\|2933722_2933950_-	hypothetical protein	NA	NA	NA	NA
WP_001064901.1\|2934222_2934912_-	antiterminator	I6PDF8	Cronobacter_phage	2.7e-55	47.2
WP_000904158.1\|2934908_2935268_-	RusA family crossover junction endodeoxyribonuclease	V5URS4	Shigella_phage	4.6e-38	64.9
WP_021553035.1\|2935280_2936270_-	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	2.1e-186	94.5
WP_021553034.1\|2936322_2936580_-	hypothetical protein	Q8W639	Enterobacteria_phage	4.7e-21	68.8
WP_021553033.1\|2936576_2937977_-	replicative DNA helicase	Q8W640	Enterobacteria_phage	3.2e-244	91.8
WP_000988266.1\|2937973_2938873_-	ATP-binding protein	Q8W641	Enterobacteria_phage	2.3e-139	94.8
WP_032301910.1\|2938883_2939870_-	hypothetical protein	Q8W642	Enterobacteria_phage	1.7e-55	96.3
2939222:2939237	attL	NA	NA	NA	NA
WP_000618007.1\|2940162_2940387_-	hypothetical protein	NA	NA	NA	NA
WP_000626793.1\|2940383_2940578_-	hypothetical protein	NA	NA	NA	NA
WP_024226990.1\|2940574_2941426_-	hypothetical protein	A0A1C9IHV9	Salmonella_phage	3.1e-93	66.5
WP_001090258.1\|2941534_2942242_-	DNA-binding protein	Q8W645	Enterobacteria_phage	3.9e-118	91.1
WP_000838344.1\|2942577_2943234_+	helix-turn-helix domain-containing protein	Q8W648	Enterobacteria_phage	3.1e-125	97.7
WP_021556323.1\|2943337_2943838_+	helix-turn-helix domain-containing protein	Q8W649	Enterobacteria_phage	1.8e-64	96.2
WP_000141093.1\|2944128_2944335_+	hypothetical protein	Q8W651	Enterobacteria_phage	1.3e-29	94.1
WP_021556324.1\|2944529_2944718_+	hypothetical protein	Q8W652	Enterobacteria_phage	1.8e-09	50.9
WP_001199104.1\|2944723_2945305_+	hypothetical protein	Q8W653	Enterobacteria_phage	1.9e-70	65.1
WP_000179800.1\|2945553_2945871_+	DUF4752 family protein	A0A1I9LJV1	Stx_converting_phage	5.2e-38	82.6
WP_001300189.1\|2945824_2946139_+	hypothetical protein	B1GS43	Salmonella_phage	2.8e-39	86.0
WP_001289973.1\|2946806_2947292_+	ead/Ea22-like family protein	A5VWB3	Enterobacteria_phage	1.1e-42	86.1
WP_021556325.1\|2947805_2947991_+	hypothetical protein	Q1MVF7	Enterobacteria_phage	3.5e-18	88.7
WP_000206826.1\|2947987_2948332_+	hypothetical protein	A0A2R2Z2X8	Escherichia_phage	3.8e-58	99.1
WP_000457723.1\|2948416_2948659_+	DUF4222 domain-containing protein	Q6H9Z8	Enterobacteria_phage	4.3e-32	87.5
WP_105375194.1\|2948662_2948809_+	hypothetical protein	A0A1B5FPC2	Escherichia_phage	2.4e-22	93.8
WP_000528718.1\|2948817_2949054_+	excisionase family protein	Q8W657	Enterobacteria_phage	6.4e-41	100.0
WP_000362005.1\|2949109_2950423_+\|integrase	site-specific integrase	Q8W658	Enterobacteria_phage	4.1e-246	95.6
WP_042196262.1\|2950404_2951175_+	DUF72 domain-containing protein	Q859D1	Escherichia_coli_phage	5.7e-70	96.9
WP_000252980.1\|2951227_2951623_+	hypothetical protein	NA	NA	NA	NA
WP_000019591.1\|2951663_2952407_+	carboxy-S-adenosyl-L-methionine synthase CmoA	F5B419	Synechococcus_phage	4.6e-24	30.0
WP_000564730.1\|2952403_2953375_+\|tRNA	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	NA	NA	NA	NA
WP_001578498.1\|2953409_2955839_-	trimethylamine N-oxide reductase TorZ	NA	NA	NA	NA
WP_020233068.1\|2955863_2956964_-	cytochrome c	NA	NA	NA	NA
WP_020233067.1\|2957349_2958096_-	copper homeostasis protein CutC	NA	NA	NA	NA
WP_001304291.1\|2958109_2958676_-	VOC family protein	NA	NA	NA	NA
WP_001025322.1\|2958891_2960625_+\|tRNA	arginine--tRNA ligase	A0A2K9L6Z2	Tupanvirus	3.4e-86	33.5
2958886:2958901	attR	NA	NA	NA	NA

DBSCAN-SWA_6

3146770 : 3154288

Escherichia_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_021523155.1\|3146770_3147319_-	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A291LA62	Escherichia_phage	4.4e-48	54.4
WP_021523156.1\|3147323_3148202_-	glucose-1-phosphate thymidylyltransferase RfbA	A0A291LA53	Escherichia_phage	1.9e-106	64.5
WP_021523157.1\|3148259_3149159_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.7e-28	35.1
WP_001515524.1\|3149158_3150244_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	2.3e-101	54.2
WP_105375195.1\|3150615_3151509_-	UTP--glucose-1-phosphate uridylyltransferase GalF	A0A127AW70	Bacillus_phage	1.0e-46	42.0
WP_021523159.1\|3151740_3152736_-	SDR family oxidoreductase	A0A1V0QG29	Shearwaterpox_virus	2.5e-09	26.0
WP_021523160.1\|3152893_3154288_-	colanic acid biosynthesis protein WcaM	A0A291LBB9	Klebsiella_phage	9.8e-20	31.9

DBSCAN-SWA_7

3201693 : 3253681

Escherichia_phage(33.33%)

holin,terminase,head,portal,transposase,capsid,integrase,plate,tRNA,lysis,tail

attL 3205982:3206008|attR 3238880:3238906

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000675148.1\|3201693_3203097_+	two-component system sensor histidine kinase BaeS	W8CYF6	Bacillus_phage	2.7e-33	29.4
WP_000137877.1\|3203093_3203816_+	two-component system response regulator BaeR	W8CYM9	Bacillus_phage	3.7e-31	33.6
WP_000929408.1\|3203995_3204328_+	YegP family protein	NA	NA	NA	NA
WP_001520824.1\|3204475_3205837_+\|tRNA	tRNA 5-hydroxyuridine modification protein YegQ	Q6DW11	Phage_TP	1.6e-216	99.2
3205982:3206008	attL	NA	NA	NA	NA
WP_000468308.1\|3206109_3206328_-	prophage transcriptional regulator OgrK	A0A0F7LDQ9	Escherichia_phage	4.7e-38	100.0
WP_042002646.1\|3206409_3207573_-	phage late control D family protein	U5N3V4	Enterobacteria_phage	1.0e-203	98.7
WP_000978914.1\|3207572_3208052_-\|tail	phage tail protein	Q7Y4C7	Escherichia_virus	4.3e-84	99.4
WP_000785970.1\|3210506_3210626_-\|tail	GpE family phage tail protein	A0A0F7LCR6	Escherichia_phage	1.0e-15	100.0
WP_001031307.1\|3210658_3210934_-\|tail	phage tail assembly protein	A0A0F7LDQ8	Escherichia_phage	2.2e-40	98.9
WP_001554312.1\|3210990_3211509_-\|tail	phage major tail tube protein	A0A0F7LDZ1	Escherichia_phage	3.2e-93	99.4
WP_042002647.1\|3211521_3212712_-\|tail	phage tail sheath protein	A0A0F7LBW9	Escherichia_phage	1.8e-224	99.2
WP_042002648.1\|3212971_3213664_-	hypothetical protein	Q858R9	Enterobacteria_phage	1.4e-123	98.3
WP_001406733.1\|3214155_3214335_+	DUF3606 domain-containing protein	NA	NA	NA	NA
WP_000002748.1\|3214387_3214666_+	hypothetical protein	NA	NA	NA	NA
WP_001695638.1\|3214869_3215397_-\|tail	tail fiber assembly protein	U5N0T1	Enterobacteria_phage	1.2e-90	95.4
WP_060578154.1\|3215400_3217719_-\|tail	phage tail protein	U5N099	Enterobacteria_phage	6.3e-213	68.1
WP_028985810.1\|3217729_3218260_-\|tail	phage tail protein I	A0A0F7LDF3	Escherichia_phage	3.9e-102	99.4
WP_001121497.1\|3218252_3219161_-\|plate	baseplate assembly protein	U5N3T9	Enterobacteria_phage	1.5e-162	100.0
WP_000127164.1\|3219165_3219513_-\|plate	baseplate assembly protein	A0A0F7LDQ1	Escherichia_phage	1.3e-58	100.0
WP_021525814.1\|3219509_3220145_-\|plate	phage baseplate assembly protein V	U5N3F0	Enterobacteria_phage	8.5e-112	97.6
WP_042002650.1\|3220228_3221014_+	hypothetical protein	NA	NA	NA	NA
WP_042002651.1\|3221085_3221538_-	phage virion morphogenesis protein	A0A0F7LDR6	Escherichia_phage	1.7e-74	97.3
WP_021517192.1\|3221530_3221998_-\|tail	phage tail protein	U5N0S7	Enterobacteria_phage	7.4e-81	97.4
WP_001695628.1\|3222105_3222531_-\|lysis	LysB family phage lysis regulatory protein	Q858W0	Yersinia_virus	1.0e-65	97.2
WP_021548484.1\|3222518_3222944_-	hypothetical protein	Q858W1	Yersinia_virus	1.5e-59	89.4
WP_042002652.1\|3222958_3223456_-	glycoside hydrolase family 104 protein	A0A0F7LBS0	Escherichia_phage	1.5e-92	99.4
WP_000123123.1\|3223455_3223737_-\|holin	holin	A0A0F7LA12	Escherichia_phage	1.3e-43	100.0
WP_000846409.1\|3223740_3223944_-\|tail	tail protein X	A0A0F7LCN2	Escherichia_phage	3.0e-31	100.0
WP_000988633.1\|3223943_3224453_-\|head	head completion/stabilization protein	U5N0S3	Enterobacteria_phage	1.1e-90	100.0
WP_021548483.1\|3224552_3225296_-\|terminase	terminase endonuclease subunit	Q858W5	Yersinia_virus	4.6e-125	98.8
WP_042002653.1\|3225299_3226373_-\|capsid	phage major capsid protein, P2 family	Q94MC7	Enterobacteria_phage	1.9e-201	99.4
WP_001607695.1\|3226431_3227286_-\|capsid	GPO family capsid scaffolding protein	A0A0F7LA11	Escherichia_phage	1.7e-139	100.0
WP_000156844.1\|3227459_3229232_+\|terminase	terminase ATPase subunit family protein	A0A0F7LCM8	Escherichia_phage	0.0e+00	99.8
WP_000038161.1\|3229231_3230266_+\|portal	phage portal protein	A0A0F7LDI7	Escherichia_phage	1.9e-201	100.0
WP_042002654.1\|3230583_3231240_-	hypothetical protein	NA	NA	NA	NA
WP_042002655.1\|3231323_3232055_-	hypothetical protein	A0A218M4H5	Erwinia_phage	1.0e-108	78.6
WP_042002656.1\|3232206_3232419_+	hypothetical protein	NA	NA	NA	NA
WP_042002657.1\|3232490_3232943_-	DUF3850 domain-containing protein	Q2P9X4	Enterobacteria_phage	3.0e-79	96.0
WP_042002658.1\|3232942_3235228_-	replication endonuclease	Q7Y4B8	Escherichia_virus	0.0e+00	98.3
WP_000027664.1\|3235217_3235493_-	DUF5405 family protein	U5N3W1	Enterobacteria_phage	3.8e-45	100.0
WP_001113264.1\|3235489_3235714_-	TraR/DksA family transcriptional regulator	S4TRY6	Salmonella_phage	2.9e-35	100.0
WP_042002659.1\|3235716_3236016_-	DUF5405 family protein	S4TUD1	Salmonella_phage	3.5e-44	98.0
WP_000557698.1\|3236015_3236240_-	DUF2732 family protein	S4TP68	Salmonella_phage	5.2e-32	97.3
WP_000217677.1\|3236303_3236804_-	hypothetical protein	A0A0F7LBQ6	Escherichia_phage	4.5e-92	100.0
WP_001005162.1\|3236800_3236971_-	hypothetical protein	S4TNZ7	Salmonella_phage	6.1e-25	100.0
WP_000043869.1\|3236981_3237257_-	hypothetical protein	Q1JS62	Enterobacteria_phage	1.3e-48	100.0
WP_001306384.1\|3237371_3237671_+	helix-turn-helix transcriptional regulator	Q1JS63	Enterobacteria_phage	2.5e-50	100.0
WP_000985262.1\|3237786_3238800_+\|integrase	site-specific integrase	Q83VS6	Escherichia_phage	2.4e-193	98.8
WP_001303579.1\|3239076_3239394_-	hypothetical protein	NA	NA	NA	NA
3238880:3238906	attR	NA	NA	NA	NA
WP_000807371.1\|3239808_3240708_+	lipid kinase YegS	A0A1V0SBJ0	Catovirus	4.8e-12	29.0
WP_000178552.1\|3240789_3241569_-	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_001520826.1\|3241668_3242709_-	galactitol-1-phosphate 5-dehydrogenase	NA	NA	NA	NA
WP_033550567.1\|3242756_3243014_-	hypothetical protein	NA	NA	NA	NA
WP_001352368.1\|3243086_3244295_+\|transposase	IS4-like element ISVsa5 family transposase	A0A0F7LAS3	uncultured_marine_virus	1.8e-235	100.0
WP_000599533.1\|3244660_3245866_-	sodium/glutamate symporter	NA	NA	NA	NA
WP_000562370.1\|3246309_3246630_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_000460651.1\|3246622_3247009_+	hypothetical protein	NA	NA	NA	NA
WP_001284954.1\|3247016_3247703_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000088605.1\|3247680_3248304_-	tetracycline resistance transcriptional repressor TetR(B)	NA	NA	NA	NA
WP_001089068.1\|3248385_3249591_+	tetracycline efflux MFS transporter Tet(B)	A0A2H4UVM2	Bodo_saltans_virus	3.0e-09	24.4
WP_000428546.1\|3249703_3250297_-	tetracyline resistance-associated transcriptional repressor TetC	NA	NA	NA	NA
WP_000422741.1\|3251264_3251690_+	IS66 family insertion sequence hypothetical protein	Q6H9S5	Enterobacteria_phage	1.5e-48	99.0
WP_000624722.1\|3251686_3252037_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	4.7e-40	66.4
WP_000080195.1\|3252067_3253681_+\|transposase	IS66-like element ISEc23 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.0e-182	63.6

DBSCAN-SWA_8

3289223 : 3298666

Enterobacteria_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001520842.1\|3289223_3290360_+	VWA domain-containing protein	Q9EYF7	Enterobacteria_phage	2.5e-162	97.4
WP_021523183.1\|3290356_3292357_+	hypothetical protein	Q9EYF6	Enterobacteria_phage	0.0e+00	95.7
WP_001295429.1\|3292481_3292943_+	YehR family lipoprotein	Q9EYF5	Enterobacteria_phage	1.9e-76	100.0
WP_001295430.1\|3292984_3293455_-	DUF1456 family protein	Q9EYF4	Enterobacteria_phage	1.8e-82	100.0
WP_000598641.1\|3293501_3294221_-	two-component system response regulator BtsR	NA	NA	NA	NA
WP_001309587.1\|3294217_3295903_-	two-component regulatory system sensor histidine kinase BtsS	Q9EYF3	Enterobacteria_phage	7.3e-304	99.5
WP_001240398.1\|3296124_3296856_+	HTH-type transcriptional regulator MlrA	Q9EYF2	Enterobacteria_phage	2.8e-111	99.0
WP_001216963.1\|3296915_3297023_+	protein YohO	NA	NA	NA	NA
WP_000783145.1\|3297003_3297735_-	glycine betaine ABC transporter permease YehW	NA	NA	NA	NA
WP_000569374.1\|3297739_3298666_-	glycine betaine ABC transporter ATP binding protein YehX	G3M9Y6	Bacillus_virus	4.8e-23	30.8

DBSCAN-SWA_9

3701897 : 3743811

Escherichia_phage(58.0%)

holin,terminase,integrase

attL 3703736:3703752|attR 3744002:3744018

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000017552.1\|3701897_3702050_-	hypothetical protein	G9L6F3	Escherichia_phage	1.7e-18	96.0
WP_000076001.1\|3702067_3702259_+	DUF2633 family protein	G9L6F2	Escherichia_phage	7.3e-27	100.0
WP_014639259.1\|3702569_3703088_+	glycine zipper 2TM domain-containing protein	G9L6F1	Escherichia_phage	2.9e-62	99.4
WP_001521044.1\|3703103_3703643_+	DUF5384 family protein	G9L6F0	Escherichia_phage	1.6e-42	96.6
3703736:3703752	attL	NA	NA	NA	NA
WP_021523198.1\|3703839_3704337_-	DUF2514 domain-containing protein	A0A193GYU6	Enterobacter_phage	6.7e-48	66.5
WP_021523199.1\|3704333_3704963_-	glycoside hydrolase family 19 protein	G9L6E8	Escherichia_phage	2.9e-112	96.7
WP_000256098.1\|3704952_3705261_-\|holin	phage holin family protein	G9L6E7	Escherichia_phage	1.3e-49	100.0
WP_021523200.1\|3705247_3705652_-	hypothetical protein	G9L6E6	Escherichia_phage	2.3e-62	94.8
WP_021523201.1\|3705827_3708434_-	SGNH/GDSL hydrolase family protein	G9L6E4	Escherichia_phage	2.7e-79	65.2
WP_001546908.1\|3708629_3708887_+	hypothetical protein	A0A0F6R8M4	Escherichia_coli_O157_typing_phage	3.7e-42	97.6
WP_001546909.1\|3709024_3709156_+	hypothetical protein	NA	NA	NA	NA
WP_001546910.1\|3709201_3709894_+	hypothetical protein	G9L6E2	Escherichia_phage	2.2e-97	80.2
WP_000163644.1\|3710023_3710350_+	hypothetical protein	NA	NA	NA	NA
WP_000479990.1\|3710336_3710849_+	hypothetical protein	NA	NA	NA	NA
WP_000708858.1\|3710930_3711092_+	hypothetical protein	G9L6D9	Escherichia_phage	2.5e-20	100.0
WP_001147904.1\|3711123_3711420_-	hypothetical protein	A0A2R9YJP3	Escherichia_phage	2.5e-50	100.0
WP_021523202.1\|3711615_3714090_-	hypothetical protein	A0A0F6TK45	Escherichia_coli_O157_typing_phage	0.0e+00	99.3
WP_021523203.1\|3714095_3715898_-	hypothetical protein	A0A0F6TJQ3	Escherichia_coli_O157_typing_phage	0.0e+00	98.0
WP_021523204.1\|3715894_3718408_-	hypothetical protein	A0A0F6R8M6	Escherichia_coli_O157_typing_phage	0.0e+00	97.4
WP_021523205.1\|3718407_3718953_-	hypothetical protein	A0A0F6TJ56	Escherichia_coli_O157_typing_phage	1.8e-86	93.9
WP_021523206.1\|3718952_3719417_-	hypothetical protein	G9L6D1	Escherichia_phage	1.9e-84	99.4
WP_021523207.1\|3719416_3721888_-	hypothetical protein	G9L6D0	Escherichia_phage	0.0e+00	98.7
WP_000179265.1\|3721887_3722493_-	hypothetical protein	A0A0F6TJN5	Escherichia_coli_O157_typing_phage	4.7e-112	99.5
WP_000424495.1\|3722492_3722816_-	hypothetical protein	A0A0F6R8M8	Escherichia_coli_O157_typing_phage	2.6e-53	98.1
WP_001546919.1\|3722866_3723202_-	hypothetical protein	G9L6C7	Escherichia_phage	8.5e-55	99.1
WP_001546921.1\|3723212_3723650_-	hypothetical protein	A0A0F6R7N9	Escherichia_coli_O157_typing_phage	1.4e-70	95.2
WP_021523208.1\|3723701_3724688_-	hypothetical protein	G9L6C5	Escherichia_phage	5.6e-187	99.4
WP_001546923.1\|3724702_3725398_-	hypothetical protein	G9L6C4	Escherichia_phage	6.0e-95	100.0
WP_000133160.1\|3725400_3725697_-	hypothetical protein	G9L6C3	Escherichia_phage	1.3e-46	100.0
WP_021523209.1\|3725693_3727373_-	hypothetical protein	G9L6C2	Escherichia_phage	8.0e-303	99.3
WP_000335899.1\|3727387_3727594_-	hypothetical protein	G9L6C1	Escherichia_phage	6.0e-11	100.0
WP_057950734.1\|3728345_3729047_+	hypothetical protein	NA	NA	NA	NA
WP_021523211.1\|3729258_3730728_-	hypothetical protein	G9L6B8	Escherichia_phage	6.8e-290	97.8
WP_024166494.1\|3730724_3731435_-\|terminase	terminase small subunit	Q287B7	Escherichia_phage	1.0e-105	85.2
WP_021523213.1\|3731475_3731814_-	hypothetical protein	A0A0F6TJR3	Escherichia_coli_O157_typing_phage	3.5e-56	96.4
WP_021523214.1\|3731928_3732588_-	DUF550 domain-containing protein	S4TSR6	Salmonella_phage	1.4e-53	61.9
WP_021523215.1\|3732598_3733354_-	hypothetical protein	A0A1R3Y5Q7	Salmonella_virus	6.5e-143	93.2
WP_021523216.1\|3733355_3734252_-	ead/Ea22-like family protein	A0A088CC42	Shigella_phage	2.9e-158	88.9
WP_021523217.1\|3734248_3734725_-	hypothetical protein	A0A2I6TCH0	Escherichia_phage	9.4e-31	68.8
WP_016235747.1\|3734786_3735131_-	DUF1064 domain-containing protein	A0A0F6R8N5	Escherichia_coli_O157_typing_phage	8.2e-61	97.4
WP_001406039.1\|3735248_3736034_-	hypothetical protein	A0A0F6TJ71	Escherichia_coli_O157_typing_phage	9.3e-153	100.0
WP_021523218.1\|3736030_3736846_-	hypothetical protein	Q286X4	Escherichia_phage	1.7e-117	95.6
WP_000402896.1\|3736861_3737062_-	hypothetical protein	A0A0F6TJB7	Escherichia_coli_O157_typing_phage	1.0e-31	98.5
WP_001282459.1\|3737212_3737443_-	hypothetical protein	G9L6A7	Escherichia_phage	2.6e-39	100.0
WP_000836290.1\|3737597_3738182_+	helix-turn-helix transcriptional regulator	A0A0F6R8L7	Escherichia_coli_O157_typing_phage	7.0e-105	100.0
WP_001198620.1\|3738335_3738488_+	hypothetical protein	G9L6A5	Escherichia_phage	5.4e-25	100.0
WP_021523219.1\|3738490_3738790_+	hypothetical protein	G9L6A4	Escherichia_phage	5.8e-47	99.0
WP_021523220.1\|3738786_3739608_+	hypothetical protein	A0A2R9YJH7	Escherichia_phage	1.5e-161	98.5
WP_001617197.1\|3739604_3740546_+	recombinase RecT	A0A0F6TJP0	Escherichia_coli_O157_typing_phage	1.0e-177	99.7
WP_000675390.1\|3740595_3740844_+	AlpA family phage regulatory protein	A0A0F6TJ45	Escherichia_coli_O157_typing_phage	3.6e-42	100.0
WP_021523221.1\|3740953_3741253_+	PerC family transcriptional regulator	A0A2R9YJK3	Escherichia_phage	1.3e-49	98.0
WP_023153950.1\|3741245_3741896_+	MT-A70 protein	G9L699	Escherichia_phage	5.2e-125	96.3
WP_001055435.1\|3741892_3742552_+	serine/threonine protein phosphatase	K7P6H8	Enterobacteria_phage	4.4e-103	79.5
WP_021523223.1\|3742554_3743811_-\|integrase	site-specific integrase	A0A0F6TJM5	Escherichia_coli_O157_typing_phage	4.4e-237	99.0
3744002:3744018	attR	NA	NA	NA	NA

DBSCAN-SWA_10

3964065 : 3971205

Escherichia_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001272917.1\|3964065_3966627_+	DNA mismatch repair protein MutS	E3T5Q7	Cafeteria_roenbergensis_virus	9.2e-32	20.8
WP_001141345.1\|3966732_3967389_+	protein-serine/threonine phosphatase	A0A077SLQ6	Escherichia_phage	5.0e-51	47.0
WP_001295181.1\|3967439_3968207_-	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	2.5e-70	56.7
WP_000847993.1\|3968402_3969311_+	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	1.1e-117	76.5
WP_001521147.1\|3969307_3970570_+	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	1.3e-135	61.4
WP_001278994.1\|3970566_3971205_+	aldolase	A0A077SK32	Escherichia_phage	1.4e-82	75.0

DBSCAN-SWA_11

4219105 : 4262603

Staphylococcus_phage(25.0%)

integrase,protease,transposase,tRNA

attL 4234979:4234993|attR 4250608:4250622

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001319878.1\|4219105_4219864_+\|protease	metalloprotease LoiP	NA	NA	NA	NA
WP_000105566.1\|4220069_4220990_-	agmatinase	NA	NA	NA	NA
WP_001556203.1\|4221127_4223104_-	biosynthetic arginine decarboxylase	NA	NA	NA	NA
WP_001297406.1\|4223112_4223244_-	acid stress response protein YqgB	NA	NA	NA	NA
WP_001303650.1\|4223379_4223595_+	hypothetical protein	NA	NA	NA	NA
WP_001062128.1\|4223898_4225053_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	4.0e-128	63.2
WP_001112301.1\|4225488_4226883_+	galactose/proton symporter	NA	NA	NA	NA
WP_032142436.1\|4226959_4227457_+\|protease	SprT family zinc-dependent metalloprotease	NA	NA	NA	NA
WP_000286517.1\|4227551_4228259_+	deoxyribonuclease I	NA	NA	NA	NA
WP_001222509.1\|4228338_4229070_+	16S rRNA (uracil(1498)-N(3))-methyltransferase	NA	NA	NA	NA
WP_000593273.1\|4229082_4230033_+	glutathione synthase	NA	NA	NA	NA
WP_000126441.1\|4230069_4230705_+	YqgE/AlgH family protein	NA	NA	NA	NA
WP_000017111.1\|4230704_4231121_+	Holliday junction resolvase RuvX	NA	NA	NA	NA
WP_001389259.1\|4231295_4232276_-	type IV pilus twitching motility protein PilT	NA	NA	NA	NA
WP_000997795.1\|4232293_4232998_+	pyridoxal phosphate homeostasis protein	NA	NA	NA	NA
WP_001094831.1\|4233015_4233582_+	osmotic shock tolerance protein YggT	NA	NA	NA	NA
WP_001277222.1\|4233578_4233869_+	YggU family protein	NA	NA	NA	NA
WP_001174735.1\|4233876_4234470_+	XTP/dITP diphosphatase	NA	NA	NA	NA
WP_000239928.1\|4234462_4235599_+	radical SAM family heme chaperone HemW	NA	NA	NA	NA
4234979:4234993	attL	NA	NA	NA	NA
WP_000745217.1\|4235753_4236761_-	DUF1202 family protein	NA	NA	NA	NA
WP_000394125.1\|4236877_4237924_-	L-asparaginase 2	NA	NA	NA	NA
WP_000984796.1\|4238099_4238819_-	DUF2884 domain-containing protein	NA	NA	NA	NA
WP_001107564.1\|4239002_4239329_-	YggL family protein	NA	NA	NA	NA
WP_000786911.1\|4239328_4240048_-\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
WP_001295382.1\|4240208_4241261_+	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_000091700.1\|4241288_4241564_+	oxidative damage protection protein	NA	NA	NA	NA
WP_001298916.1\|4241628_4242708_+	membrane-bound lytic murein transglycosylase MltC	NA	NA	NA	NA
WP_001049791.1\|4242909_4244166_+	nucleoside permease NupG	NA	NA	NA	NA
WP_000839790.1\|4244214_4246350_-	ornithine decarboxylase	NA	NA	NA	NA
WP_000234533.1\|4246742_4247450_+	DUF554 domain-containing protein	NA	NA	NA	NA
WP_005761259.1\|4247828_4249094_+\|integrase	integrase arm-type DNA-binding domain-containing protein	Q7M297	Enterobacteria_phage	3.3e-75	37.6
WP_000612632.1\|4251357_4251705_-	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	1.4e-60	98.3
4250608:4250622	attR	NA	NA	NA	NA
WP_001221615.1\|4252436_4252871_-	hypothetical protein	NA	NA	NA	NA
WP_000270971.1\|4252858_4253260_-	hypothetical protein	NA	NA	NA	NA
WP_000221530.1\|4253519_4254089_-	inovirus Gp2 family protein	NA	NA	NA	NA
WP_000840364.1\|4255208_4255475_-	hypothetical protein	NA	NA	NA	NA
WP_001329787.1\|4255543_4255822_+	AlpA family transcriptional regulator	NA	NA	NA	NA
WP_000813456.1\|4255916_4256519_+	hypothetical protein	NA	NA	NA	NA
WP_000250228.1\|4257721_4258639_+	hypothetical protein	NA	NA	NA	NA
WP_057950850.1\|4258723_4259596_+	GTPase family protein	NA	NA	NA	NA
WP_004020235.1\|4259981_4260803_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_089541817.1\|4260930_4262158_+\|transposase	IS3 family transposase	Q9ZXG3	Shigella_phage	2.7e-170	95.7
WP_088561087.1\|4262342_4262603_-\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP027130

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

4210 : 64270

Escherichia_phage(47.06%)

transposase,integrase

attL 6648:6707|attR 52888:53708

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000255956.1\|4210_5233_-\|transposase	IS21-like element IS100 family transposase	A0A2L1IVA1	Escherichia_phage	1.0e-199	99.1
WP_024193849.1\|6312_6687_-	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZDM8	Stx2-converting_phage	9.8e-60	100.0
6648:6707	attL	NA	NA	NA	NA
WP_001067855.1\|6711_7416_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_000108589.1\|8132_8690_+	OsmC family protein	NA	NA	NA	NA
WP_000210409.1\|8831_9413_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_000888080.1\|9417_9756_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_002431133.1\|9785_10115_-	thioredoxin family protein	V9SJ74	Achromobacter_phage	1.3e-10	34.7
WP_000039982.1\|10328_11435_+	alkene reductase	NA	NA	NA	NA
WP_001194013.1\|11500_12202_+	DsbA family oxidoreductase	NA	NA	NA	NA
WP_032152933.1\|12267_13041_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_000872613.1\|13226_14450_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000090196.1\|14580_15453_-	DMT family transporter	NA	NA	NA	NA
WP_000734115.1\|15694_16447_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_021546935.1\|16886_17891_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_000874189.1\|19176_19662_-	hypothetical protein	NA	NA	NA	NA
WP_001267176.1\|19686_20172_-	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_000117262.1\|20158_20854_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.5e-29	38.9
WP_000729219.1\|20858_21989_-	ABC transporter permease	NA	NA	NA	NA
WP_000964653.1\|21978_23262_-	ABC transporter permease	NA	NA	NA	NA
WP_000119836.1\|23264_24644_-	DUF2318 domain-containing protein	NA	NA	NA	NA
WP_000178050.1\|24747_25275_-	iron transporter	NA	NA	NA	NA
WP_000118029.1\|25315_27202_-	FTR1 family iron permease	NA	NA	NA	NA
WP_012372823.1\|27548_28364_-	Na(+)-translocating NADH-quinone reductase subunit C	NA	NA	NA	NA
WP_000949452.1\|28546_29053_-	protein disulfide oxidoreductase	NA	NA	NA	NA
WP_000449408.1\|29042_29201_-	copper-sensitivity suppressor C	NA	NA	NA	NA
WP_000428546.1\|32052_32646_+	tetracyline resistance-associated transcriptional repressor TetC	NA	NA	NA	NA
WP_001089068.1\|32758_33964_-	tetracycline efflux MFS transporter Tet(B)	NA	NA	NA	NA
WP_000088605.1\|34045_34669_+	tetracycline resistance transcriptional repressor TetR(B)	NA	NA	NA	NA
WP_001284954.1\|34646_35333_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000460651.1\|35340_35727_-	hypothetical protein	NA	NA	NA	NA
WP_049802299.1\|35719_35983_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_001067855.1\|36865_37570_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_001137892.1\|38623_39208_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_000004159.1\|39207_40446_-	MFS transporter	NA	NA	NA	NA
WP_000219391.1\|40442_41348_-	Mph(A) family macrolide 2'-phosphotransferase	NA	NA	NA	NA
WP_001067858.1\|41469_42174_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_004883563.1\|42514_42787_-	hypothetical protein	NA	NA	NA	NA
WP_000259031.1\|42914_43754_-	sulfonamide-resistant dihydropteroate synthase Sul1	A0A0B5J4J5	Pandoravirus	5.0e-11	27.2
WP_000679427.1\|43747_44095_-	quaternary ammonium compound efflux SMR transporter QacE delta 1	NA	NA	NA	NA
WP_000503573.1\|44300_45089_-	ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA5	NA	NA	NA	NA
WP_001389366.1\|45219_45693_-	trimethoprim-resistant dihydrofolate reductase DfrA17	A0A1B2IAU3	Erwinia_phage	1.3e-16	34.6
WP_000845048.1\|45850_46864_+\|integrase	class 1 integron integrase IntI1	A0A1P8DJJ6	Virus_Rctr41k	1.0e-71	45.5
WP_032152941.1\|47066_47357_+	DUF3330 domain-containing protein	NA	NA	NA	NA
WP_001067858.1\|47393_48098_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_000239590.1\|49375_50251_+	class A extended-spectrum beta-lactamase CTX-M-15	A0A1B0VBP7	Salmonella_phage	1.1e-125	82.4
WP_001393253.1\|50297_50630_-	cupin fold metalloprotein, WbuC family	NA	NA	NA	NA
WP_001067855.1\|52951_53656_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_002063889.1\|54849_55392_-	AAA family ATPase	NA	NA	NA	NA
52888:53708	attR	NA	NA	NA	NA
WP_000557452.1\|55404_56265_-	aminoglycoside N-acetyltransferase AAC(3)-IIa	NA	NA	NA	NA
WP_001067855.1\|56371_57076_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_001334766.1\|57707_58538_-	oxacillin-hydrolyzing class D beta-lactamase OXA-1	NA	NA	NA	NA
WP_063840321.1\|58668_59223_-	fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5	NA	NA	NA	NA
WP_001067855.1\|59366_60071_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_000509965.1\|60672_61278_-	recombinase family protein	A0A1S5Y2X8	uncultured_archaeal_virus	9.4e-20	35.3
WP_001553819.1\|61372_64270_+\|transposase	Tn3-like element Tn5403 family transposase	A0A1B0V7H9	Salmonella_phage	4.2e-182	37.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_CP027129

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1447 : 4700

Escherichia_phage(66.67%)

tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064764636.1\|1447_1924_-\|tail	tail fiber protein	A0A0F7LCR3	Escherichia_phage	2.4e-47	59.4
WP_001165547.1\|1995_2568_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	4.4e-83	85.0
WP_000145199.1\|3003_3267_+	hypothetical protein	Q71TD9	Escherichia_phage	1.1e-22	67.1
WP_000887652.1\|3341_3671_+\|holin	holin	Q37876	Escherichia_phage	1.3e-52	100.0
WP_000580776.1\|3667_4111_+	hypothetical protein	A0A077SK09	Escherichia_phage	1.3e-82	100.0
WP_001345482.1\|4097_4700_+	hypothetical protein	Q1MVM6	Enterobacteria_phage	5.4e-100	100.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP027133

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP027134

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP027130

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

4. NZ_CP027129

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection