CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP027287	Campylobacter fetus subsp. testudinum strain 772 chromosome, complete genome	6 crisprs	PD-DExK,cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2,WYL,DEDDh,csa3,csx23,cas10,csm3gr7,csx10gr5,csx19	0	22	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP027287_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027287_1

706462-707409

TypeI-B

Consensus_repeat	Method
GTTTGCTAATGACAATATTTGTGTTGAAA	PILER-CR
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CRISPRCasFinder
GTTTGCTAATGACAANATTTGTGTTGAAA	CRT

14 spacers

cas6,cas8b1,cas7b,cas5

The CRISPR arrays of NZ_CP027287_1

>merge|NZ_CP027287|1|706462-707409|PILER-CR,CRISPRCasFinder,CRT
GTTTGCTAATGACAAGATTTGTGTTGAAACAACTTATGCAATACACCGGGCATACAGATAAAAACGGTTTGCTAATGACAAGATTTGTGTTGAAACAATATGAGGCAAGAAAAACAAAAGGAGGTTAGATAGTTTGCTAATGACAAGATTTGTGTTGAAACTAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGGGTTTGCTAATGACAAGATTTGTGTTGAAACTGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAGGTTTGCTAATGACAAGATTTGTGTTGAAACAGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAGGTTTGCTAATGACAAGATTTGTGTTGAAACAATGCGAATGTTTGGTATTCACTTTCATTTTTTAGGTTTGCTAATGACAAGATTTGTGTTGAAACTTTGGAGGAGCTATTGGTGTTTTAGATCCGAAATTCGTTTGCTAATGACAATATTTGTGTTGAAACAGTCCCTTTGTTTCGTACTCATATTTGTCGCCAAGCGTTTGCTAATGACAATATTTGTGTTGAAACTAAAATCCAACGTAATAAGGTAGCTTTGTTTCTACCGTTTGCTAATGACAATATTTGTGTTGAAACGATATCAAAACAAGATTATTGAAAAAGGAAATAGAAGTTTGCTAATGACAATATTTGTGTTGAAATAACAAATAGATTGGTTTTGCCGGTTGATATCGTATGTTTGCTAATGACAATATTTGTGTTGAAATAATTTTAAATCACCCCAAAGAGTATATAAAAATTTAGTTTGCTAATGACAATATTTGTGTTGAAATGCAGTTACGCTTAGTGTAATAAACAAGCCTGCAGGGTTTGCTAATGACAATATTTGTGTTGAAATAGCTCATCCCCAAATCTTTCAGACAATCCTCTTATTGTTTGCTAATGACAATATTTGTGTTGAAAC

>NZ_CP027287|1|1|706462-707408|PILER-CR
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAACTTATGCAATACACCGGGCATACAGATAAAAACG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAATATGAGGCAAGAAAAACAAAAGGAGGTTAGATA
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAATGCGAATGTTTGGTATTCACTTTCATTTTTTAG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTTTGGAGGAGCTATTGGTGTTTTAGATCCGAAATTC
GTTTGCTAATGACAATATTTGTGTTGAAA	CAGTCCCTTTGTTTCGTACTCATATTTGTCGCCAAGC
GTTTGCTAATGACAATATTTGTGTTGAAA	CTAAAATCCAACGTAATAAGGTAGCTTTGTTTCTACC
GTTTGCTAATGACAATATTTGTGTTGAAA	CGATATCAAAACAAGATTATTGAAAAAGGAAATAGAA
GTTTGCTAATGACAATATTTGTGTTGAAA	TAACAAATAGATTGGTTTTGCCGGTTGATATCGTAT
GTTTGCTAATGACAATATTTGTGTTGAAA	TAATTTTAAATCACCCCAAAGAGTATATAAAAATTTA
GTTTGCTAATGACAATATTTGTGTTGAAA	TGCAGTTACGCTTAGTGTAATAAACAAGCCTGCAGG
GTTTGCTAATGACAATATTTGTGTTGAAA	TAGCTCATCCCCAAATCTTTCAGACAATCCTCTTATT
GTTTGCTAATGACAATATTTGTGTTGAAA

>NZ_CP027287|1|1|706462-707409|CRISPRCasFinder
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AACTTATGCAATACACCGGGCATACAGATAAAAACG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AATATGAGGCAAGAAAAACAAAAGGAGGTTAGATA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AATGCGAATGTTTGGTATTCACTTTCATTTTTTAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTGGAGGAGCTATTGGTGTTTTAGATCCGAAATTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGTCCCTTTGTTTCGTACTCATATTTGTCGCCAAGC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TAAAATCCAACGTAATAAGGTAGCTTTGTTTCTACC
GTTTGCTAATGACAATATTTGTGTTGAAAC	GATATCAAAACAAGATTATTGAAAAAGGAAATAGAA
GTTTGCTAATGACAATATTTGTGTTGAAAT	AACAAATAGATTGGTTTTGCCGGTTGATATCGTAT
GTTTGCTAATGACAATATTTGTGTTGAAAT	AATTTTAAATCACCCCAAAGAGTATATAAAAATTTA
GTTTGCTAATGACAATATTTGTGTTGAAAT	GCAGTTACGCTTAGTGTAATAAACAAGCCTGCAGG
GTTTGCTAATGACAATATTTGTGTTGAAAT	AGCTCATCCCCAAATCTTTCAGACAATCCTCTTATT
GTTTGCTAATGACAATATTTGTGTTGAAAC

>NZ_CP027287|1|1|706462-707408|CRT
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAACTTATGCAATACACCGGGCATACAGATAAAAACG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAATATGAGGCAAGAAAAACAAAAGGAGGTTAGATA
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAATGCGAATGTTTGGTATTCACTTTCATTTTTTAG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTTTGGAGGAGCTATTGGTGTTTTAGATCCGAAATTC
GTTTGCTAATGACAATATTTGTGTTGAAA	CAGTCCCTTTGTTTCGTACTCATATTTGTCGCCAAGC
GTTTGCTAATGACAATATTTGTGTTGAAA	CTAAAATCCAACGTAATAAGGTAGCTTTGTTTCTACC
GTTTGCTAATGACAATATTTGTGTTGAAA	CGATATCAAAACAAGATTATTGAAAAAGGAAATAGAA
GTTTGCTAATGACAATATTTGTGTTGAAA	TAACAAATAGATTGGTTTTGCCGGTTGATATCGTAT
GTTTGCTAATGACAATATTTGTGTTGAAA	TAATTTTAAATCACCCCAAAGAGTATATAAAAATTTA
GTTTGCTAATGACAATATTTGTGTTGAAA	TGCAGTTACGCTTAGTGTAATAAACAAGCCTGCAGG
GTTTGCTAATGACAATATTTGTGTTGAAA	TAGCTCATCCCCAAATCTTTCAGACAATCCTCTTATT
GTTTGCTAATGACAATATTTGTGTTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027287.1\|WP_065840343.1\|719711_720653_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP027287.1\|WP_023384764.1\|703662_704439_+\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP027287.1\|WP_058909677.1\|720652_721414_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP027287.1\|WP_023384766.1\|704938_705676_+\|YaaA-family-protein	unknown	unknown	gnl\|CDD\|377151
NZ_CP027287.1\|WP_023384755.1\|695647_696991_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP027287.1\|WP_105459453.1\|697150_698398_-\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143398
NZ_CP027287.1\|WP_065838927.1\|716086_716455_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_039362183.1\|702023_702395_+\|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|223799
NZ_CP027287.1\|WP_023384763.1\|702370_703666_+\|putative-TPR-repeat-lipoprotein	unknown	unknown	gnl\|CDD\|274350
NZ_CP027287.1\|WP_065838945.1\|707608_707869_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_023384761.1\|701334_702030_+\|methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP027287.1\|WP_065838946.1\|708435_708723_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_023384765.1\|704438_704942_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238606
NZ_CP027287.1\|WP_065838878.1\|699415_701338_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP027287.1\|WP_023384758.1\|698452_699406_+\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379355
NZ_CP027287.1\|WP_065840345.1\|717330_718047_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP027287.1\|WP_065838926.1\|716430_716745_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_023384778.1\|718036_719728_+\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
NZ_CP027287.1\|WP_158676894.1\|709144_711469_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|106966
NZ_CP027287.1\|WP_023384768.1\|707865_708135_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP027287.1\|WP_023384764.1\|703662_704439_+\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	4.5117e-123
NZ_CP027287.1\|WP_023384766.1\|704938_705676_+\|YaaA-family-protein	gnl\|CDD\|377151	pfam03883, H2O2_YaaD, Peroxide stress protein YaaA. YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.	9.72431e-46
NZ_CP027287.1\|WP_023384755.1\|695647_696991_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP027287.1\|WP_105459453.1\|697150_698398_-\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|143398	cd07079, ALDH_F18-19_ProA-GPR, Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19. Gamma-glutamyl phosphate reductase (GPR), a L-proline biosynthetic pathway (PBP) enzyme that catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The glutamate route of the PBP involves two enzymatic steps catalyzed by gamma-glutamyl kinase (GK, EC 2.7.2.11) and GPR (EC 1.2.1.41). These enzymes are fused into the bifunctional enzyme, ProA or delta(1)-pyrroline-5-carboxylate synthetase (P5CS) in plants and animals, whereas they are separate enzymes in bacteria and yeast. In humans, the P5CS (ALDH18A1), an inner mitochondrial membrane enzyme, is essential to the de novo synthesis of the amino acids proline and arginine. Tomato (Lycopersicon esculentum) has both the prokaryotic-like polycistronic operons encoding GK and GPR (PRO1, ALDH19) and the full-length, bifunctional P5CS (PRO2, ALDH18B1).	0
NZ_CP027287.1\|WP_058909677.1\|720652_721414_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.99727e-35
NZ_CP027287.1\|WP_039362183.1\|702023_702395_+\|YkgJ-family-cysteine-cluster-protein	gnl\|CDD\|223799	COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].	1.45607e-13
NZ_CP027287.1\|WP_023384763.1\|702370_703666_+\|putative-TPR-repeat-lipoprotein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.60479e-07
NZ_CP027287.1\|WP_065838878.1\|699415_701338_+\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	4.07406e-07
NZ_CP027287.1\|WP_023384761.1\|701334_702030_+\|methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	6.37403e-55
NZ_CP027287.1\|WP_023384765.1\|704438_704942_+\|HIT-domain-containing-protein	gnl\|CDD\|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	5.95963e-47
NZ_CP027287.1\|WP_023384758.1\|698452_699406_+\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|379355	pfam13738, Pyr_redox_3, Pyridine nucleotide-disulphide oxidoreductase.	1.05556e-57
NZ_CP027287.1\|WP_065840345.1\|717330_718047_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.13307e-14
NZ_CP027287.1\|WP_158676894.1\|709144_711469_+\|hypothetical-protein	gnl\|CDD\|106966	PHA00657, PHA00657, crystallin beta/gamma motif-containing protein.	2.10372e-17
NZ_CP027287.1\|WP_065840343.1\|719711_720653_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.41874e-37

>NZ_CP027287.1|WP_023384766.1|704938_705676_+|YaaA-family-protein
MKILFSPSESKMSGGSMDTPINFSWVFPNLNDKRLEILEIYNGFLKKANKNELQTLFGLKKENELEYYSSDLFSRPLMKAILRYNGVAYEHLNYRNLDESSRKIIDENTIIFSNLYGAILAKDMICDYKLKQGETIGGFRTEVFYKKYFSSVLDDFLDFDILDLRAGFYEKFYSITKPHTTIKFLKNGKVVSHFAKAYRGIVLRYIALNQISSLDEFYNMQIPNLKINKIIKNRLKTEIIVDIIG
>NZ_CP027287.1|WP_023384765.1|704438_704942_+|HIT-domain-containing-protein
MKHEFSPWRAEYFKTRKDGVMEHNCVFCDIAQNSQNDEENFVLFRAKNCFAVMNRYPYTLGEFMIIPYIHTDNIENLDKNIWFEMSDLVQLGVGVLKESLNANGVNIGMNLGSAAGAGIAEHIHYHVVPRWSRDTNFITTIAYTRVHGVPFLDQYHALKQAFQKVLK
>NZ_CP027287.1|WP_023384764.1|703662_704439_+|indole-3-glycerol-phosphate-synthase-TrpC
MILDEIISKTKINLENIKEKLPLCKLENALTSSYVPRDVKQVLKQKNSINIIAEIKKASPSKGVIREDFDPLEIAFEYEKAGVSAFSILTEPFYFQGSLEYMALVRRYTNTPILRKDFIVDIYQIAEARLYGADFILLIAKALDKFYLKTLFEYAKSLNLEVLMEIHDEIDLEKALFVDADIIGINHRNLQTFDMDMELCVKLMPLIPGGKIIVAESGLYSNSDLVNLKKQGADAFLIGEHFMRQKSIYNAVKDMKGE
>NZ_CP027287.1|WP_023384763.1|702370_703666_+|putative-TPR-repeat-lipoprotein
MYWCRAALIFTLFLAGCADKQSVGAKKNETFFKYSDINTTMDLESMKGFYLLGDAKSKDALEVFYTLYKTTKKPIFLKESLKIAFVIKDERLDELITDARSVLNGDYDAIRIEIGYYILKSQIKEAKELALNLIQKESGNSINHSILATIYLFNDEPIRALKEFKKAYEIDDSEENLLKLVDMLDNKLDRTNEAIRYLNNWIEENGCSKPVCFTLLNIYSAKGELDLMTEMYIKLYEAYEESDFLNRALEILLYKKDVVTAKELLEKYGFNEPILMGIYAELKEFQKAYDVAQDLYSRSQNPEYMARMAIYKYEQSSKNISKFELDMVVKLFEGSVYALNSPLYFNYYGYLLIDYGIDVKKGLDIVKKAYILDPNSPYIIDSIAWGYFKLGECKEAKMWMDKIQSDTKFMKEDEAKAHKTAIDKCFNKGTK
>NZ_CP027287.1|WP_039362183.1|702023_702395_+|YkgJ-family-cysteine-cluster-protein
MLKKPGFDYCFDSSKCEVCGAKCCTGDSGYIWINEAEMESLSSHLKLSLSEFKKLFTYRVGVRFSLKEKEYNGAYACLFFDENNKNCSVYEFRPKQCRTFPFWDYFKKHFNELEKECIGVERL
>NZ_CP027287.1|WP_023384761.1|701334_702030_+|methyltransferase
MKLFQLKDGYRYNSDSLFLYDFISKNKIFGNLLDVGCGCGILGLLLKRDFVNLNLSSIDIQEINSTITQLNADVNSLVATVICDDFSKFKSEMKFDFIVSNPPFYSDQITKSQKEHINISRYSSSLDPLSFFKCVNANLKPQGTLYFCYDARRVGEILPILSSFKLKLTKLRFVHSKVSESSKLVLFEAKKSSKSMCEIYPPLIVFDGNEFSDEAKEIFKKSDTKSEIYEC
>NZ_CP027287.1|WP_065838878.1|699415_701338_+|hypothetical-protein
MKFRKFAKILFVVGTAFFILGCETKDEKALNQDKLKFSDLPMAEQDRYISKDELDKLGSYLTLLDNRNIDINSDEIPAKSVDELRDKIADLMQKNRLLFADNEELAKKNLEIITKLREQTSLRESENKLISAKYIDSMNEVEKQHYKNINDLTKKINEVQKENIQSIKSYEQKIIGLENKIDELEKELSKKDINFNEKVSSATKDQLAKNKELSQKNSYLLEQTEILKKQADALSKELDSKLADKKTQIDTLKQTILTKDNKINDLLAAHTNEIIELQNKHSKALDDLKNELNRQKNDYFGELNLKNSELAKLNTDFKEYKLKKDEELKNAENRVLANYKNIETQRLNAIKSDYERIIFEQNRTIAAFEGKMINLELKFKKELETKDANYANTLENLKQKALFLKNDEDRLRVEFDKNITSLKSQIALKNAQISDLDSKLKELENEKNDIKKIQNYEILNNMITKLNAQNEELKNYAKNALDEAKKMVLEAESRAKEQNDKLKNYYEELIKNIKNQDNQLILSDINVNSKKFLAEVSCLSLDKSAKLNKDCETKLNDMIKKYGKERIYEIKAAISDFKFLGDDKAGELKNVNLLNLKSTKDMLNAASKAISSRIKDPMLAYSKDVLLEQGGYGFVIKVYE
>NZ_CP027287.1|WP_023384758.1|698452_699406_+|NAD(P)-binding-domain-containing-protein
MENIYDVVVIGGGPFGIATVVEAKYNGFKNVLLLEKGDNHSQTIRKFYKDGKRVDKVYKGLDSQTHGNVEFFDGTKESTLNYFDNLLDSGKIDAVFNIEVESVKKDGDIFSIVTSKNTYKSKNVMIGIGRMGKPNKPEYKIPPSLTQIVNFNLNSCNCGENILVIGGGNSAAEYAIELSKCNTVTLCYRKEKFTRLNEINEAQVFEYFNDKKLNLKLGIDVISLDNENGKVKVNFSSNSSEIYDRIIYAIGGSTPVDFLQKCGIELNKDGEPIVDEHLQTNTPRLFVGGDIASKNGGSIVVALNDAHTVIDYIIKSK
>NZ_CP027287.1|WP_105459453.1|697150_698398_-|glutamate-5-semialdehyde-dehydrogenase
MLLKEQAKMEKLLNNLKNSSKSLSIITQTQRENLIINISNEIMNAKDEILSANKLDLDLAQDLSSALKDRLKLTSKSIENLCDSIKNIANLKEVIGVIKDGWQTKSGLKIEKITVPLGNIATIYESRPNVTAEVAALCIKSANGCALKGGKEARNTNLAIIKAIHKALQKCGLDKNCVVYLDIDRSEVEKLIKMDKYLDLIVPRGGENLVKFVSQNATIPVLKHDKGLCHIYVDKFADLDKALNICVNAKCSRPGVCNAAETILVHEAVANEFIPNLKKSLDQFNVIIFGCKKTAKIIDCELANEQNYSTEYLDFKLNLKIVKNLEESLEHISEFSSGHSEAVISENYSVCEMFLNLVNSACVYANASTRFSDGGEFGFGAEIGISTNKLHARGPVGLNELTTYKYIIRANGQIR
>NZ_CP027287.1|WP_023384755.1|695647_696991_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
MSKWNRDSWRDYNILQQPQYPDKNELKNAEDKLKSLPPLVFAGEVRNLKDELKNVTLGKSFLLQGGDCAESFSNFSANGIRDMFKIMLQMAIVLTFAGGCPVVKVGRVAGQFAKPRSSDFEDIDGVKLPSYRGDIINGFDFTKEARIPDPKRMIDAYYQSASTLNLLRAFSRGGLANLNEVHRWNLGFIKKAELDDKFEKLADELTGALKFMEACGVTTQNTPTLSETKLYTSHEALLLPYEEALTRVDSLTNEWYDCSAHMLWIGERTRGINDAHVHFLSGIKNPIGCKIGPDGKSSDIISLAQKLNPSNEPGRLNIIIRMGANKIEDRLPAILSDVKKEGLNILWSIDPMHGNTIKASSGFKTREFNNVMKEVKSFFEIHKSCGTIAGGVHLEMTGQDVTECVGGAFNVTEDSLGNRYETQCDPRLNADQALELAFLIADLVKKR
>NZ_CP027287.1|WP_065838945.1|707608_707869_+|hypothetical-protein
MKSYCLKLDDDTFAQLNQIVKNSKTTMAEFIRNALDQKLKETKGSLSYRLTTLSYCDKKESDEILDSLKHLNDDELKIAKKETINL
>NZ_CP027287.1|WP_023384768.1|707865_708135_+|hypothetical-protein
MKLEINYTKVSIKFFDKHKDIKDKFITNIGKFISGESVDIKALKGIEEPKLYRMRVGKFRVVFWINDKGELVIINVINADSRGGIYKGV
>NZ_CP027287.1|WP_065838946.1|708435_708723_+|hypothetical-protein
MVNPTLTFGVDLSALGSALKEIDKRTDKLSQNLNQGLKDAQKSYNNALKNLQYIKNPLKIEETIAKLNKLKADIKKATIAKFDLKIDNAKKSRRA
>NZ_CP027287.1|WP_158676894.1|709144_711469_+|hypothetical-protein
MQIRASLQYLWDNHANDGMFKNKRDIYNTIKMLIGYQDYAGNSFKNPNMAYIATKTNDKRMSDMVISRDSAGVTHLNKDKKMSETDKNIFDSKSVVETPKSQRKQQVLGVQMNTSKEHYSPTNNSIIPQNSKQVKPTSEAGDDMIAITKLKNEIDELKATKQGGKYLSSQVKAEVIDKSNELGKLIDERISQGKSINQTLVSEYKAQIQRARYQASKEAKPTSAPVKTEVKTELQNTINAKKVYEQATKDIIDFAKRQELDFNGRNLLDIKIYDMKSLEKELGGLSIWASGSINKEAKQEAKQIVDKYDQILADMRSIKANKARQTMAKNEQIANTKQQPSPNAISNTGIIPQNIDNINPASEAQNFFKTLSEYNNLRDNIAKNNKKIDNEHFTLSKSIHNEINGNLSKIFNLVKERDIAAKSRLKKLETMFKFKGVTGNEALKDYLDDLTLMHFNSFSKEELDFIKLTKDKIIKSQGDILAGANKARSFRYGNLDTADDLKNKVFKLFSDLNIKANNFFELEPLLLSHSAKENELRHIVSLDTVSNARLAMEKEANITPIKEFGTNYAEFYHDGSNAIKKLLIEKQGQVAGAFEKEGKDITLVWGIEGTSHSDGYGLSKIAKYHPEAVDNLDNIISKGEFYKDEKGRLNIKYNDDIVGLRENWLGNETVPWIISSYTKKAETSKGFNSASSITPSKENYSFTTQHNNIIPQNTKFDNTPTFLNKYPKLIDDLKWDKTLKFSSAPKSKEELKARQAFLNEFKILSSKEKIDIKI
>NZ_CP027287.1|WP_065838927.1|716086_716455_+|hypothetical-protein
MKNTSPLSKDEAVKHIDKTGVERVLSKQNYFGENNHSKPLYKRVPKSDVVKALNSINTMAKNKDNKYINAFSDNGYFIVFNGNEIVTCYKHKDGNKATFNYFKSASIYDKKEVIKWKIANLL
>NZ_CP027287.1|WP_065838926.1|716430_716745_+|hypothetical-protein
MENRKLIIGYYGIEWDIKVPGYDEDKADVLKIIKPITSVMDGKIVEVFDILTPHKEDIDDAKEYKEFYEICDFEVPQTNHKFTGTFIDALEYIKDTFNQVSKTV
>NZ_CP027287.1|WP_065840345.1|717330_718047_+|CRISPR-associated-endoribonuclease-Cas6
MKIYQLKVFLKLNQNVDFINSPEFLSTNLHKAMLGDEALRSIHMQRYLKPYSIGFLYSMKGKKDTFVSGEDMYFYVRSIDESFISKLRICLENSKNLGFNVHSSKLEHLDIKQIDRLYTMSPATIVLKEGDKTIPWRRENSDITVLKEALISNLKNKYEYFLDKKIEIKDDIIELIEIKTNRAFAFRYKNGKIYAYRYQIHFSQNRLAQEFANIAMILGIGVKNTLGFGFCMRSNNAV
>NZ_CP027287.1|WP_023384778.1|718036_719728_+|hypothetical-protein
MLFELLDEFKKQLEKNKHIVTQNHILKDGVYARISDEKCEIFYVKTITEKIGKTAQKRTILYKQNGDIALNDDMQWFEQADYLSFLWDMNKAVLPNKKFHSINFLSLFFKLEESEYVKENLEEYFDIFRDYSAFNKAKDKEILSFYMDYIKDENRQNLITNSVVLSKKYFNDINDFAVQNNFKKCYIKFFIDKDFEIYEKESQIYIDLKIYNSNEHNIKYNNEIFGLSNFNMGMNSKKPFLEHKNRLFKIPYAISQKDALASKMLFDWLGSQNKRIIRDFNSIFISKFNKQSKAVVSDFEYVPVDKNKFKFDKFKLKNFMNIENGEKEILSFDDFKQVIDEQLYHKCLFGNLYNDEIRVSKRISEDMQNLLYQTRCSMVEYFDKFNNNEFYYVIQKYSNDFIKIAMQDSEFGRLNGKKSINLLLSIKEIKGEKVDIDGIKNRVISALTDDNVTKLSGNEYYFLVGNLAMYLVSKSKTWKKTFALTDPYTKARNTKKLKMALFIDFDRYNYDIFLENGILKKAFSLAQNCEDIVMSNNDQQMVLIGMMTKNIIKKPGEKDEISE
>NZ_CP027287.1|WP_065840343.1|719711_720653_+|CRISPR-associated-protein
MKLANRIYGIIGIKSTMANWNADFSGRPKSTGNGDIFASDKALKYPMKKMWESYGKNILFVKSLKQGKSKDGNDKLVPNTLGERYGLLFGDIKKAKSTKEVLSNLFNCIDVKNFGATFPEDGYNLSITGAVQIGQGFNKFGDINIEVQNILSPFADSRAKEKNENGEDASQSTLGTKIVTDEAHYFYGFCINPLAYNDYKEILGDDFGYNEDDYAEFKKAARFCATYFNSNSKFGCENEFAMFIETAVDAYLPDLSSYMDFICKDKNRSVNLEKIEKMIESSDVKKVEIYYNPLSLDVETKFDKFDIYSGNKI
>NZ_CP027287.1|WP_058909677.1|720652_721414_+|type-I-B-CRISPR-associated-protein-Cas5
MKAISFKLSGKFAHFKKPDVNEYVYFTYNNIPKPTLLGLLGAIIGLKGYAQKTYNNKKDKKSLLNNENRSNEPEFYERLKHLKICIIPLVKYGKFSKKIQVFNNSVGYASTEEGGNLIVREQWLENPSWQILIEDDGSAEFETISQYLFDKKAKFIPYLGKNDHFADISEVEKIDLAESKKDKIVIKSLFLDNLAKQVDDPDDEISYLFNEFYPIGFNELMFYKLEKTTFTNQICQAMDGKWYEFKDGTICFF

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Crispr_ID: NZ_CP027287_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027287_2

712179-715891

TypeI-B

Consensus_repeat	Method
GTTTGCTAATGACAATATTTGTGTTGAAAC	PILER-CR
GTTTGCTAATGACAATATTTGTGTTGAAAC	CRISPRCasFinder
GTTTGCTAATGACAANATTTGTGTTGAAAC	CRT

56 spacers

cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

The CRISPR arrays of NZ_CP027287_2

>merge|NZ_CP027287|2|712179-715891|PILER-CR,CRISPRCasFinder,CRT
GTTTGCTAATGACAAGATTTGTGTTGAAACGTATTCTCCAAAATAATATAAGTCCGAGCATTCTCCGTTTGCTAATGACAAGATTTGTGTTGAAACTAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGGGTTTGCTAATGACAAGATTTGTGTTGAAACTGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAGGTTTGCTAATGACAAGATTTGTGTTGAAACAGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAGGTTTGCTAATGACAAGATTTGTGTTGAAACTAGATTGATATTTGACGGGAAAAATCTAAGCACAGTTTGCTAATGACAAGATTTGTGTTGAAACTCTATCATTTTAAATTTCCTTTTTTTCTTTATTCTGTTTGCTAATGACAAGATTTGTGTTGAAACTAATATCGGCTGGGTTTATAATAGCCCCATTGCAACGTTTGCTAATGACAAGATTTGTGTTGAAACTAGCCTCGTAAAATAGCCTATCGCTCGCTTTTCTGGTTTGCTAATGACAAGATTTGTGTTGAAACAGTATAGATTTAAAACAAGCAAATTTGAAATTGGAAGTTTGCTAATGACAAGATTTGTGTTGAAACATTTGAACTACAGGTACATTTATAACATCAAATAAGTTTGCTAATGACAAGATTTGTGTTGAAACACTGTCAAGCACGACTATAAAAAGAGCTTTGATATAGGTTTGCTAATGACAAGATTTGTGTTGAAACTTTGGAGTTTTAAACAGAGATTTAGTATCTCCATACGTTTGCTAATGACAATATTTGTGTTGAAACAATTGATATATGCAAATATATCTCTATTGTAAAGCCGTTTGCTAATGACAATATTTGTGTTGAAACGGTGTTGAAACGTCTATTTACTTTTTAAAGGATGAGTTTGCTAATGACAATATTTGTGTTGAAACAAACACTACACCACCAATTACCCCTAATAACACTCTGTTTGCTAATGACAATATTTGTGTTGAAACTTGGAAAACTCCTCCGTCTTAAGCTTTACTTGTGCTTGTTTGCTAATGACAATATTTGTGTTGAAACCCCCTATTAAATATAACCACCAATGAACCGTCAATGGTTTGCTAATGACAATATTTGTGTTGAAACATATCTTTTACATTTTTACCATCTGTTGCTAAAATAGTTTGCTAATGACAATATTTGTGTTGAAACTTAAATGAGGCACTTGCAGTAGATAAAACTACTTGTTTGCTAATGACAATATTTGTGTTGAAACGCTTTTAGCTTAGCTATCTCCACTCTATCGCTTTCTGTTTGCTAATGACAATATTTGTGTTGAAACTTAAATTCTTGAACTTTGTTCGCTTGATTTATATCTGTTTGCTAATGACAATATTTGTGTTGAAACTTTTTTATACTATTTATAGAAGCTTTTTGAGCATAGTTTGCTAATGACAATATTTGTGTTGAAACAAGTTCATTCGAGCGATATTAGAGCTCCGCTTCCAAGTTTGCTAATGACAATATTTGTGTTGAAACACATACTGCAGAGCTTTTTCCAGGTCTTGCACACCAGTTTGCTAATGACAATATTTGTGTTGAAACAGGCTATGCGTAAAAACTTCTACTGGGTAAAAAATGGTTTGCTAATGACAATATTTGTGTTGAAACCTGATATCTGTTTTTACGGTTTTTTTAAATTCATCTGTTTGCTAATGACAAGATTTGTGTTGAAACGAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCTGTTTGCTAATGACAATATTTGTGTTGAAACCGTTCAGCTTCCATTGACAAACCACCTTTTAAAATAGTTTGCTAATGACAATATTTGTGTTGAAACTTTCTTGCGAGATCATTTACGTGGCATGGGCTTATAGTTTGCTAATGACAATATTTGTGTTGAAACTTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCAGTTTGCTAATGACAATATTTGTGTTGAAACCTGATATCTGTTTTTACGGTTTTTTTAAATTCATCTGTTTGCTAATGACAAGATTTGTGTTGAAACTGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATAGTTTACTAATGACAATATTTGTGTTGAAACTCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTCGTTTGCTAATGACAATATTTGTGTTGAAACTTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCAGTTTGCTAATGACAATATTTGTGTTGAAACTTGTACACAGGGTATGTAAGATCTGTTGTAATCTCGTTTGCTAATGACAATATTTGTGTTGAAACTGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATAGTTTACTAATGACAATATTTGTGTTGAAACTCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTCGTTTGCTAATGACAATATTTGTGTTGAAACAACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAAGTTTGCTAATGACAAGATTTGTGTTGAAACAGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTAGTTTGCTAATGACAAGATTTGTGTTGAAACTAGACCTATATTTCGTAAATTTATAAAAGATATGGTTGTTTGCTAATGACAAGATTTGTGTTGAAACCACATAACATAATAGCTGATATAAACTACAGATATAGTTTGCTAATGACAATATTTGTGTTGAAACACTTTATATATACAAGTTACTTTAGCAGTAGAAACAGTTTGCTAATGACAATATTTGTGTTGAAACTATTTAGGGAGAATAACATCATTTGCCGGATTTACTGTTTGCTAATGACAATATTTGTGTTGAAACACCTAAACAAGAAATTATATCTCCTAATATTCAAAAGTTTGCTAATGACAATATTTGTGTTGAAACAAGTAAGGATTAATTTTGTCTGATAGTTTTGTTAATGTTTGCTAATGACAATATTTGTGTTGAAACAGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTAGTTTGCTAATGACAAGATTTGTGTTGAAACCACATAACATAATAGCTGATATAAACTACAGATATAGTTTGCTAATGACAATATTTGTGTTGAAACACTTTATATATACAAGTTACTTTAGCAGTAGAAACAGTTTGCTAATGACAATATTTGTGTTGAAACTGCTAAGGCTAAGCGTATAATGGACGCGCTAAGTGGTTTGCTAATGACAATATTTGTGTTGAAACTTTAATAGTGCTCTTAAAACTGGCTTTTTATTATTTGTTTGCTAATGACAAGATTTGTGTTGAAACTTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCAGTTTGCTAATGACAATATTTGTGTTGAAACTGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATAGTTTACTAATGACAATATTTGTGTTGAAACTCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTCGTTTGCTAATGACAATATTTGTGTTGAAACAACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAAGTTTGCTAATGACAAGATTTGTGTTGAAACAGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTAGTTTGCTAATGACAAGATTTGTGTTGAAACCCCAAAGCTGCTACCAAAAATCCATAACCGATAGTAGTTTGCTAATAACAAAGCTCATATTAAAAT

>NZ_CP027287|2|2|712179-715825|PILER-CR
GTTTGCTAATGACAAGATTTGTGTTGAAAC	GTATTCTCCAAAATAATATAAGTCCGAGCATTCTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGATTGATATTTGACGGGAAAAATCTAAGCACA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TCTATCATTTTAAATTTCCTTTTTTTCTTTATTCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAATATCGGCTGGGTTTATAATAGCCCCATTGCAAC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGCCTCGTAAAATAGCCTATCGCTCGCTTTTCTG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGTATAGATTTAAAACAAGCAAATTTGAAATTGGAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ATTTGAACTACAGGTACATTTATAACATCAAATAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ACTGTCAAGCACGACTATAAAAAGAGCTTTGATATAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTGGAGTTTTAAACAGAGATTTAGTATCTCCATAC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AATTGATATATGCAAATATATCTCTATTGTAAAGCC
GTTTGCTAATGACAATATTTGTGTTGAAAC	GGTGTTGAAACGTCTATTTACTTTTTAAAGGATGA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAACACTACACCACCAATTACCCCTAATAACACTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGGAAAACTCCTCCGTCTTAAGCTTTACTTGTGCTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	CCCCTATTAAATATAACCACCAATGAACCGTCAATG
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATATCTTTTACATTTTTACCATCTGTTGCTAAAATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAATGAGGCACTTGCAGTAGATAAAACTACTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	GCTTTTAGCTTAGCTATCTCCACTCTATCGCTTTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAATTCTTGAACTTTGTTCGCTTGATTTATATCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTATACTATTTATAGAAGCTTTTTGAGCATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAGTTCATTCGAGCGATATTAGAGCTCCGCTTCCAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACATACTGCAGAGCTTTTTCCAGGTCTTGCACACCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGGCTATGCGTAAAAACTTCTACTGGGTAAAAAATG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTGATATCTGTTTTTACGGTTTTTTTAAATTCATCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	GAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	CGTTCAGCTTCCATTGACAAACCACCTTTTAAAATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTCTTGCGAGATCATTTACGTGGCATGGGCTTATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTGATATCTGTTTTTACGGTTTTTTTAAATTCATCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGTACACAGGGTATGTAAGATCTGTTGTAATCTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGACCTATATTTCGTAAATTTATAAAAGATATGGTT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CACATAACATAATAGCTGATATAAACTACAGATATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTTTATATATACAAGTTACTTTAGCAGTAGAAACA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TATTTAGGGAGAATAACATCATTTGCCGGATTTACT
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACCTAAACAAGAAATTATATCTCCTAATATTCAAAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAGTAAGGATTAATTTTGTCTGATAGTTTTGTTAAT
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CACATAACATAATAGCTGATATAAACTACAGATATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTTTATATATACAAGTTACTTTAGCAGTAGAAACA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGCTAAGGCTAAGCGTATAATGGACGCGCTAAGTG
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAATAGTGCTCTTAAAACTGGCTTTTTATTATTT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC

>NZ_CP027287|2|2|712179-715891|CRISPRCasFinder
GTTTGCTAATGACAAGATTTGTGTTGAAAC	GTATTCTCCAAAATAATATAAGTCCGAGCATTCTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGATTGATATTTGACGGGAAAAATCTAAGCACA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TCTATCATTTTAAATTTCCTTTTTTTCTTTATTCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAATATCGGCTGGGTTTATAATAGCCCCATTGCAAC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGCCTCGTAAAATAGCCTATCGCTCGCTTTTCTG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGTATAGATTTAAAACAAGCAAATTTGAAATTGGAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ATTTGAACTACAGGTACATTTATAACATCAAATAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ACTGTCAAGCACGACTATAAAAAGAGCTTTGATATAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTGGAGTTTTAAACAGAGATTTAGTATCTCCATAC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AATTGATATATGCAAATATATCTCTATTGTAAAGCC
GTTTGCTAATGACAATATTTGTGTTGAAAC	GGTGTTGAAACGTCTATTTACTTTTTAAAGGATGA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAACACTACACCACCAATTACCCCTAATAACACTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGGAAAACTCCTCCGTCTTAAGCTTTACTTGTGCTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	CCCCTATTAAATATAACCACCAATGAACCGTCAATG
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATATCTTTTACATTTTTACCATCTGTTGCTAAAATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAATGAGGCACTTGCAGTAGATAAAACTACTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	GCTTTTAGCTTAGCTATCTCCACTCTATCGCTTTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAATTCTTGAACTTTGTTCGCTTGATTTATATCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTATACTATTTATAGAAGCTTTTTGAGCATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAGTTCATTCGAGCGATATTAGAGCTCCGCTTCCAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACATACTGCAGAGCTTTTTCCAGGTCTTGCACACCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGGCTATGCGTAAAAACTTCTACTGGGTAAAAAATG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTGATATCTGTTTTTACGGTTTTTTTAAATTCATCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	GAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	CGTTCAGCTTCCATTGACAAACCACCTTTTAAAATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTCTTGCGAGATCATTTACGTGGCATGGGCTTATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTGATATCTGTTTTTACGGTTTTTTTAAATTCATCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGTACACAGGGTATGTAAGATCTGTTGTAATCTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGACCTATATTTCGTAAATTTATAAAAGATATGGTT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CACATAACATAATAGCTGATATAAACTACAGATATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTTTATATATACAAGTTACTTTAGCAGTAGAAACA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TATTTAGGGAGAATAACATCATTTGCCGGATTTACT
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACCTAAACAAGAAATTATATCTCCTAATATTCAAAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAGTAAGGATTAATTTTGTCTGATAGTTTTGTTAAT
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CACATAACATAATAGCTGATATAAACTACAGATATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTTTATATATACAAGTTACTTTAGCAGTAGAAACA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGCTAAGGCTAAGCGTATAATGGACGCGCTAAGTG
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAATAGTGCTCTTAAAACTGGCTTTTTATTATTT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CCCAAAGCTGCTACCAAAAATCCATAACCGATAGTA
GTTTGCTAATAACAAAGCTCATATTAAAAT

>NZ_CP027287|2|2|712179-715891|CRT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	GTATTCTCCAAAATAATATAAGTCCGAGCATTCTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAAAAAAGCATAGCTAGGGCGTCTAACTCATCCGGG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGGGAAGAAAGAGAGTATTATTCTTCTCGTATAAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGCTGACTTGATAGCTAGTCGTATTAAAAAAAGAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGATTGATATTTGACGGGAAAAATCTAAGCACA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TCTATCATTTTAAATTTCCTTTTTTTCTTTATTCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAATATCGGCTGGGTTTATAATAGCCCCATTGCAAC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGCCTCGTAAAATAGCCTATCGCTCGCTTTTCTG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGTATAGATTTAAAACAAGCAAATTTGAAATTGGAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ATTTGAACTACAGGTACATTTATAACATCAAATAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ACTGTCAAGCACGACTATAAAAAGAGCTTTGATATAG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTGGAGTTTTAAACAGAGATTTAGTATCTCCATAC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AATTGATATATGCAAATATATCTCTATTGTAAAGCC
GTTTGCTAATGACAATATTTGTGTTGAAAC	GGTGTTGAAACGTCTATTTACTTTTTAAAGGATGA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAACACTACACCACCAATTACCCCTAATAACACTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGGAAAACTCCTCCGTCTTAAGCTTTACTTGTGCTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	CCCCTATTAAATATAACCACCAATGAACCGTCAATG
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATATCTTTTACATTTTTACCATCTGTTGCTAAAATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAATGAGGCACTTGCAGTAGATAAAACTACTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	GCTTTTAGCTTAGCTATCTCCACTCTATCGCTTTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAATTCTTGAACTTTGTTCGCTTGATTTATATCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTATACTATTTATAGAAGCTTTTTGAGCATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAGTTCATTCGAGCGATATTAGAGCTCCGCTTCCAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACATACTGCAGAGCTTTTTCCAGGTCTTGCACACCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGGCTATGCGTAAAAACTTCTACTGGGTAAAAAATG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTGATATCTGTTTTTACGGTTTTTTTAAATTCATCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	GAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	CGTTCAGCTTCCATTGACAAACCACCTTTTAAAATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTCTTGCGAGATCATTTACGTGGCATGGGCTTATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTGATATCTGTTTTTACGGTTTTTTTAAATTCATCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGTACACAGGGTATGTAAGATCTGTTGTAATCTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAGACCTATATTTCGTAAATTTATAAAAGATATGGTT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CACATAACATAATAGCTGATATAAACTACAGATATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTTTATATATACAAGTTACTTTAGCAGTAGAAACA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TATTTAGGGAGAATAACATCATTTGCCGGATTTACT
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACCTAAACAAGAAATTATATCTCCTAATATTCAAAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AAGTAAGGATTAATTTTGTCTGATAGTTTTGTTAAT
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CACATAACATAATAGCTGATATAAACTACAGATATA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTTTATATATACAAGTTACTTTAGCAGTAGAAACA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGCTAAGGCTAAGCGTATAATGGACGCGCTAAGTG
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTAATAGTGCTCTTAAAACTGGCTTTTTATTATTT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TTTAAATTGTCATAGTGCTTGTATAGTTCCCAGCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTTCTGTTTTTGCGGTGCGGTTAAAGTCCATTATA
GTTTACTAATGACAATATTTGTGTTGAAAC	TCCGGATTTAGCAAGGAAGCTTTAGCTCTAGCTTC
GTTTGCTAATGACAATATTTGTGTTGAAAC	AACGAAAAAGAAGGAAGTTGGGCTGAGGGCATAAAA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AGGTGCATTCATCGTCGTTTAGTTTCACTATCTCTA
GTTTGCTAATGACAAGATTTGTGTTGAAAC	CCCAAAGCTGCTACCAAAAATCCATAACCGATAGTA
GTTTGCTAATAACAAAGCTCATATTAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027287.1\|WP_065840343.1\|719711_720653_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP027287.1\|WP_023384764.1\|703662_704439_+\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP027287.1\|WP_023384768.1\|707865_708135_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_065838927.1\|716086_716455_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_065840345.1\|717330_718047_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP027287.1\|WP_023384789.1\|725280_725580_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP027287.1\|WP_058909205.1\|723788_724274_+\|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP027287.1\|WP_039362183.1\|702023_702395_+\|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|223799
NZ_CP027287.1\|WP_023384761.1\|701334_702030_+\|methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP027287.1\|WP_065838945.1\|707608_707869_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_065838946.1\|708435_708723_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_023384765.1\|704438_704942_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238606
NZ_CP027287.1\|WP_158004735.1\|721401_723792_+\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP027287.1\|WP_023384787.1\|724282_725284_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP027287.1\|WP_058909677.1\|720652_721414_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP027287.1\|WP_023384763.1\|702370_703666_+\|putative-TPR-repeat-lipoprotein	unknown	unknown	gnl\|CDD\|274350
NZ_CP027287.1\|WP_065838926.1\|716430_716745_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_023384778.1\|718036_719728_+\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
NZ_CP027287.1\|WP_158676894.1\|709144_711469_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|106966
NZ_CP027287.1\|WP_023384766.1\|704938_705676_+\|YaaA-family-protein	unknown	unknown	gnl\|CDD\|377151

Protein	Function_ID	Function_description	E-value
NZ_CP027287.1\|WP_023384764.1\|703662_704439_+\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	4.5117e-123
NZ_CP027287.1\|WP_065840343.1\|719711_720653_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.41874e-37
NZ_CP027287.1\|WP_065840345.1\|717330_718047_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.13307e-14
NZ_CP027287.1\|WP_023384789.1\|725280_725580_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.43889e-17
NZ_CP027287.1\|WP_058909205.1\|723788_724274_+\|Dna2/Cas4-domain-containing-protein	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	8.19216e-56
NZ_CP027287.1\|WP_039362183.1\|702023_702395_+\|YkgJ-family-cysteine-cluster-protein	gnl\|CDD\|223799	COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].	1.45607e-13
NZ_CP027287.1\|WP_023384763.1\|702370_703666_+\|putative-TPR-repeat-lipoprotein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.60479e-07
NZ_CP027287.1\|WP_023384761.1\|701334_702030_+\|methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	6.37403e-55
NZ_CP027287.1\|WP_023384765.1\|704438_704942_+\|HIT-domain-containing-protein	gnl\|CDD\|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	5.95963e-47
NZ_CP027287.1\|WP_158004735.1\|721401_723792_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	8.62714e-29
NZ_CP027287.1\|WP_023384787.1\|724282_725284_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.63336e-139
NZ_CP027287.1\|WP_058909677.1\|720652_721414_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.99727e-35
NZ_CP027287.1\|WP_158676894.1\|709144_711469_+\|hypothetical-protein	gnl\|CDD\|106966	PHA00657, PHA00657, crystallin beta/gamma motif-containing protein.	2.10372e-17
NZ_CP027287.1\|WP_023384766.1\|704938_705676_+\|YaaA-family-protein	gnl\|CDD\|377151	pfam03883, H2O2_YaaD, Peroxide stress protein YaaA. YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.	9.72431e-46

>NZ_CP027287.1|WP_158676894.1|709144_711469_+|hypothetical-protein
MQIRASLQYLWDNHANDGMFKNKRDIYNTIKMLIGYQDYAGNSFKNPNMAYIATKTNDKRMSDMVISRDSAGVTHLNKDKKMSETDKNIFDSKSVVETPKSQRKQQVLGVQMNTSKEHYSPTNNSIIPQNSKQVKPTSEAGDDMIAITKLKNEIDELKATKQGGKYLSSQVKAEVIDKSNELGKLIDERISQGKSINQTLVSEYKAQIQRARYQASKEAKPTSAPVKTEVKTELQNTINAKKVYEQATKDIIDFAKRQELDFNGRNLLDIKIYDMKSLEKELGGLSIWASGSINKEAKQEAKQIVDKYDQILADMRSIKANKARQTMAKNEQIANTKQQPSPNAISNTGIIPQNIDNINPASEAQNFFKTLSEYNNLRDNIAKNNKKIDNEHFTLSKSIHNEINGNLSKIFNLVKERDIAAKSRLKKLETMFKFKGVTGNEALKDYLDDLTLMHFNSFSKEELDFIKLTKDKIIKSQGDILAGANKARSFRYGNLDTADDLKNKVFKLFSDLNIKANNFFELEPLLLSHSAKENELRHIVSLDTVSNARLAMEKEANITPIKEFGTNYAEFYHDGSNAIKKLLIEKQGQVAGAFEKEGKDITLVWGIEGTSHSDGYGLSKIAKYHPEAVDNLDNIISKGEFYKDEKGRLNIKYNDDIVGLRENWLGNETVPWIISSYTKKAETSKGFNSASSITPSKENYSFTTQHNNIIPQNTKFDNTPTFLNKYPKLIDDLKWDKTLKFSSAPKSKEELKARQAFLNEFKILSSKEKIDIKI
>NZ_CP027287.1|WP_065838946.1|708435_708723_+|hypothetical-protein
MVNPTLTFGVDLSALGSALKEIDKRTDKLSQNLNQGLKDAQKSYNNALKNLQYIKNPLKIEETIAKLNKLKADIKKATIAKFDLKIDNAKKSRRA
>NZ_CP027287.1|WP_023384768.1|707865_708135_+|hypothetical-protein
MKLEINYTKVSIKFFDKHKDIKDKFITNIGKFISGESVDIKALKGIEEPKLYRMRVGKFRVVFWINDKGELVIINVINADSRGGIYKGV
>NZ_CP027287.1|WP_065838945.1|707608_707869_+|hypothetical-protein
MKSYCLKLDDDTFAQLNQIVKNSKTTMAEFIRNALDQKLKETKGSLSYRLTTLSYCDKKESDEILDSLKHLNDDELKIAKKETINL
>NZ_CP027287.1|WP_023384766.1|704938_705676_+|YaaA-family-protein
MKILFSPSESKMSGGSMDTPINFSWVFPNLNDKRLEILEIYNGFLKKANKNELQTLFGLKKENELEYYSSDLFSRPLMKAILRYNGVAYEHLNYRNLDESSRKIIDENTIIFSNLYGAILAKDMICDYKLKQGETIGGFRTEVFYKKYFSSVLDDFLDFDILDLRAGFYEKFYSITKPHTTIKFLKNGKVVSHFAKAYRGIVLRYIALNQISSLDEFYNMQIPNLKINKIIKNRLKTEIIVDIIG
>NZ_CP027287.1|WP_023384765.1|704438_704942_+|HIT-domain-containing-protein
MKHEFSPWRAEYFKTRKDGVMEHNCVFCDIAQNSQNDEENFVLFRAKNCFAVMNRYPYTLGEFMIIPYIHTDNIENLDKNIWFEMSDLVQLGVGVLKESLNANGVNIGMNLGSAAGAGIAEHIHYHVVPRWSRDTNFITTIAYTRVHGVPFLDQYHALKQAFQKVLK
>NZ_CP027287.1|WP_023384764.1|703662_704439_+|indole-3-glycerol-phosphate-synthase-TrpC
MILDEIISKTKINLENIKEKLPLCKLENALTSSYVPRDVKQVLKQKNSINIIAEIKKASPSKGVIREDFDPLEIAFEYEKAGVSAFSILTEPFYFQGSLEYMALVRRYTNTPILRKDFIVDIYQIAEARLYGADFILLIAKALDKFYLKTLFEYAKSLNLEVLMEIHDEIDLEKALFVDADIIGINHRNLQTFDMDMELCVKLMPLIPGGKIIVAESGLYSNSDLVNLKKQGADAFLIGEHFMRQKSIYNAVKDMKGE
>NZ_CP027287.1|WP_023384763.1|702370_703666_+|putative-TPR-repeat-lipoprotein
MYWCRAALIFTLFLAGCADKQSVGAKKNETFFKYSDINTTMDLESMKGFYLLGDAKSKDALEVFYTLYKTTKKPIFLKESLKIAFVIKDERLDELITDARSVLNGDYDAIRIEIGYYILKSQIKEAKELALNLIQKESGNSINHSILATIYLFNDEPIRALKEFKKAYEIDDSEENLLKLVDMLDNKLDRTNEAIRYLNNWIEENGCSKPVCFTLLNIYSAKGELDLMTEMYIKLYEAYEESDFLNRALEILLYKKDVVTAKELLEKYGFNEPILMGIYAELKEFQKAYDVAQDLYSRSQNPEYMARMAIYKYEQSSKNISKFELDMVVKLFEGSVYALNSPLYFNYYGYLLIDYGIDVKKGLDIVKKAYILDPNSPYIIDSIAWGYFKLGECKEAKMWMDKIQSDTKFMKEDEAKAHKTAIDKCFNKGTK
>NZ_CP027287.1|WP_039362183.1|702023_702395_+|YkgJ-family-cysteine-cluster-protein
MLKKPGFDYCFDSSKCEVCGAKCCTGDSGYIWINEAEMESLSSHLKLSLSEFKKLFTYRVGVRFSLKEKEYNGAYACLFFDENNKNCSVYEFRPKQCRTFPFWDYFKKHFNELEKECIGVERL
>NZ_CP027287.1|WP_023384761.1|701334_702030_+|methyltransferase
MKLFQLKDGYRYNSDSLFLYDFISKNKIFGNLLDVGCGCGILGLLLKRDFVNLNLSSIDIQEINSTITQLNADVNSLVATVICDDFSKFKSEMKFDFIVSNPPFYSDQITKSQKEHINISRYSSSLDPLSFFKCVNANLKPQGTLYFCYDARRVGEILPILSSFKLKLTKLRFVHSKVSESSKLVLFEAKKSSKSMCEIYPPLIVFDGNEFSDEAKEIFKKSDTKSEIYEC
>NZ_CP027287.1|WP_065838927.1|716086_716455_+|hypothetical-protein
MKNTSPLSKDEAVKHIDKTGVERVLSKQNYFGENNHSKPLYKRVPKSDVVKALNSINTMAKNKDNKYINAFSDNGYFIVFNGNEIVTCYKHKDGNKATFNYFKSASIYDKKEVIKWKIANLL
>NZ_CP027287.1|WP_065838926.1|716430_716745_+|hypothetical-protein
MENRKLIIGYYGIEWDIKVPGYDEDKADVLKIIKPITSVMDGKIVEVFDILTPHKEDIDDAKEYKEFYEICDFEVPQTNHKFTGTFIDALEYIKDTFNQVSKTV
>NZ_CP027287.1|WP_065840345.1|717330_718047_+|CRISPR-associated-endoribonuclease-Cas6
MKIYQLKVFLKLNQNVDFINSPEFLSTNLHKAMLGDEALRSIHMQRYLKPYSIGFLYSMKGKKDTFVSGEDMYFYVRSIDESFISKLRICLENSKNLGFNVHSSKLEHLDIKQIDRLYTMSPATIVLKEGDKTIPWRRENSDITVLKEALISNLKNKYEYFLDKKIEIKDDIIELIEIKTNRAFAFRYKNGKIYAYRYQIHFSQNRLAQEFANIAMILGIGVKNTLGFGFCMRSNNAV
>NZ_CP027287.1|WP_023384778.1|718036_719728_+|hypothetical-protein
MLFELLDEFKKQLEKNKHIVTQNHILKDGVYARISDEKCEIFYVKTITEKIGKTAQKRTILYKQNGDIALNDDMQWFEQADYLSFLWDMNKAVLPNKKFHSINFLSLFFKLEESEYVKENLEEYFDIFRDYSAFNKAKDKEILSFYMDYIKDENRQNLITNSVVLSKKYFNDINDFAVQNNFKKCYIKFFIDKDFEIYEKESQIYIDLKIYNSNEHNIKYNNEIFGLSNFNMGMNSKKPFLEHKNRLFKIPYAISQKDALASKMLFDWLGSQNKRIIRDFNSIFISKFNKQSKAVVSDFEYVPVDKNKFKFDKFKLKNFMNIENGEKEILSFDDFKQVIDEQLYHKCLFGNLYNDEIRVSKRISEDMQNLLYQTRCSMVEYFDKFNNNEFYYVIQKYSNDFIKIAMQDSEFGRLNGKKSINLLLSIKEIKGEKVDIDGIKNRVISALTDDNVTKLSGNEYYFLVGNLAMYLVSKSKTWKKTFALTDPYTKARNTKKLKMALFIDFDRYNYDIFLENGILKKAFSLAQNCEDIVMSNNDQQMVLIGMMTKNIIKKPGEKDEISE
>NZ_CP027287.1|WP_065840343.1|719711_720653_+|CRISPR-associated-protein
MKLANRIYGIIGIKSTMANWNADFSGRPKSTGNGDIFASDKALKYPMKKMWESYGKNILFVKSLKQGKSKDGNDKLVPNTLGERYGLLFGDIKKAKSTKEVLSNLFNCIDVKNFGATFPEDGYNLSITGAVQIGQGFNKFGDINIEVQNILSPFADSRAKEKNENGEDASQSTLGTKIVTDEAHYFYGFCINPLAYNDYKEILGDDFGYNEDDYAEFKKAARFCATYFNSNSKFGCENEFAMFIETAVDAYLPDLSSYMDFICKDKNRSVNLEKIEKMIESSDVKKVEIYYNPLSLDVETKFDKFDIYSGNKI
>NZ_CP027287.1|WP_058909677.1|720652_721414_+|type-I-B-CRISPR-associated-protein-Cas5
MKAISFKLSGKFAHFKKPDVNEYVYFTYNNIPKPTLLGLLGAIIGLKGYAQKTYNNKKDKKSLLNNENRSNEPEFYERLKHLKICIIPLVKYGKFSKKIQVFNNSVGYASTEEGGNLIVREQWLENPSWQILIEDDGSAEFETISQYLFDKKAKFIPYLGKNDHFADISEVEKIDLAESKKDKIVIKSLFLDNLAKQVDDPDDEISYLFNEFYPIGFNELMFYKLEKTTFTNQICQAMDGKWYEFKDGTICFF
>NZ_CP027287.1|WP_158004735.1|721401_723792_+|CRISPR-associated-helicase-Cas3'
MLLLNIYLAHTAPNKDPETLQAHCDLTKEYLQKIKNSKNLNDIIKNLANQILNDDVILEFFDDFIINHDLGKMNPAFQRFKMENKEFNEASGESTHSNHSFNKLKDKYRDFFSNSTDQDIDKIICVFYYLLSNVLNHHGHLKDGFDDKYLKISDKEEDFDRLDKKFYNSRMRIDFDFELFILIKLHFSLLIASDFYATSEYMNDIKIDDFGVFDKDKKEIIYSKFREFYSSLKPRSDIDILRSDIFQKSSKTLYDNLDKNIFYLEAPTGSGKTLTSLNLALNLLNLNSNLNKIFYVFPFNTLISQSKSIFESIFGDEFDISVINSITPPKFNKGNDQENSESKYDKTYINRVFYNHPFILTSHVALFKTLFGISKEENYGLFSLANSVIILDEIQSYRSNLWEFMALFFDSFAKHLNIKFIIMSATLPKISNLLKNNDDKWCDLLANSNYFQNTLFKDRVKVDFSLLEIGQDELFETIVSKIKEHKKDKILVEFIKKSSARDFYNFIRFKFDGYDIFELSGDDNKLYQKIVIAKLKNSNTKAIVVATQVIEAGVDIDMDIGFKDIATFESEEQFLGRINRSALKPGSLAYFFDYDNASMIYKNDSRIKFSLKDDGLKKCLIDKNFNPYYEKLLYELKCENSRVNGGFNSVRENFQKYISSINFIKISENMQLINDDRVRIFLPFKIDVSDFDMSEYGDVEHFMDGNFLDGKKIWEAIICLNEVKEYGKRKIEALSLNSLADIFSFNVFMVDDLLSISSQMRYGYIYIEDCDGFIDENGKFDRTAFAKKFNNEDLLL
>NZ_CP027287.1|WP_058909205.1|723788_724274_+|Dna2/Cas4-domain-containing-protein
MKITGTLINYFFHCKRQCYLFYNRINLEDNSEDVKIGKVLHEIKFEDEIKFENIALDKITDEYVIEFKKSDSDETASMWQLLFYLKKLKEIGIFRKGLLEFGENRNLPTKRLKVELTTHKELELEQIYSQISELMSLKTPPDPLKSSLKCKKCAYFNYCFI
>NZ_CP027287.1|WP_023384787.1|724282_725284_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MPKLHTRYIFSMGELSRKDNSLAFKNEKGTTYIPIVGIREIYCMNEVSMNSKLFDFLAKNGITIHFFNYYGNYSGSFYPKKHLISGRIITSQVEALATRNIIAKSIVKGIALNMHEVLYHYYRHGKTELKPLLDYLKLKVPNMLINANTIPQIMFIEGQIWSKFYDSFELFLDESFSLAKRVKRPPDNPMNAMISFGNSLLYTKTISAIYQTHLEQSISYLHESSDARFSLSLDLSEVFKPIIVFKTVFELINLKKINIKKHFEKKVEFCLLNEAGRKIFVESFEERLNESFLHSKLGRKVSYKTALKLEGYKLIKFICEAREFIPFSLKDKR
>NZ_CP027287.1|WP_023384789.1|725280_725580_+|CRISPR-associated-endonuclease-Cas2
MTNYNYAYVFYDISDKESEAGKRRVAKVFKLCKKYFLHHQKSVFKGEITPSNFIKFKSAVEKLIDKNIDVITILRLIRKDDIDEMTLGGLDFVKNEMFL

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Crispr_ID: NZ_CP027287_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027287_3

726147-728223

TypeI-B

Consensus_repeat	Method
GTTTGCTAATGACAATATTTGTGTTGAAA	PILER-CR
GTTTGCTAATGACAATATTTGTGTTGAAAC	CRISPRCasFinder
GTTTGCTAATGACAATATTTGTGTTGAAAC	CRT

31 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NZ_CP027287_3

>merge|NZ_CP027287|3|726147-728223|PILER-CR,CRISPRCasFinder,CRT
GTTTGCTAATGACAATATTTGTGTTGAAACTATTACTAGTTATATGGCTAGTATATCTGCTTCCTGTTTGCTAATGACAATATTTGTGTTGAAACTTTTTTTTACTATAGCCCAAATAGCCGCTATTACGGGTTTGCTAATGACAATATTTGTGTTGAAACTAAAACAAAAACAAAGGCTAAAATGATATACACAAGGTTTGCTAATGACAATATTTGTGTTGAAACACTACAGGTACATTAGATATTTTTAAATCTAATGTTGTTTGCTAATGACAATATTTGTGTTGAAACTCTGTTACAAAGCCTACTTGCTTTAAGCCCTGGCTGTTTGCTAATGACAATATTTGTGTTGAAACTTAAAATACCTTGACAAGTCTAAAATTTTATACTAGTTTGCTAATGACAATATTTGTGTTGAAATTTGCTATTTGCAAATTTTGCAGGGACGGCTTTACCAGTTTGCTAATGACAATATTTGTGTTGAAACTTAGCTCTTGCGATGGCTTTATCAAAATTCATATTTAGTTTGCTAATGACAATATTTGTGTTGAAACTTTTTTCTTGCTGTGCGTTTAAAGCCTCTTGCTGTGTTTGCTAATGACAATATTTGTGTTGAAACTGTGGTAGCCCCCTGCTTAACCAGTTGTTCGAAAGTAGTTTGCTAATGACAATATTTGTGTTGAAACAGTTTCCTACGCAGGACAAAAGAGCGCATACTCTGTGTTTGCTAATGACAATATTTGTGTTGAAACGCGATTTTCTTTAATAAAATTAATCGCCTCGTCTGGTTTGCTAATGACAATATTTGTGTTGAAACCAATTTTTAAAGATATTCTCCCCTAGATTTGATCCGTTTGCTAATGACAATATTTGTGTTGAAACTTAAAAGATAGGAAGCAATTTACAGAGGAAAAAAGTTTGCTAATGACAATATTTGTGTTGAAACATCTCTATGGCTTTGCTTTCTTTTAATGGATCTACGTTTGCTAATGACAATATTTGTGTTGAAACGAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCTGTTTGCTAATGACAAGATTTGTGTTGAAACACTTTTTTCACTTCAGTTATTGTAGTCATTCCAGGGGTTTGCTAATGACAATATTTGTGTTGAAATTTGCCTTGTGTTAGTCTTATGGTTATTTGGTTAGAAGTTTGCTAATGACAATATTTGTGTTGAAACATAATTATTGAAGAATATTTTTGTTTTAGACTTCTGTTTGCTAATGACAATATTTGTGTTGAAACTTGCAGACTTTCCACTCTACTTTGTCTTGTTTGCCATTGTTTGCTAATGACAATATTTGTGTTGAAACTCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCCGTTTGCTAATGACAAGATTTGTGTTGAAACAAGATTTCTATTAATAATCAAATTTTAGAGGAACAAGTTTGCTAATGACAATATTTGTGTTGAAACGGCGAAGGACACTGTTGATAAAGGCATAGCTAGTGGGTTTGCTAATGACAATATTTGTGTTGAAACCTTTGATGATAACTTTTTGGCTCTTTTGTGTGATATGTTTGCTAATGACAATATTTGTGTTGAAACTCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCCGTTTGCTAATGACAAGATTTGTGTTGAAACTAAAAATTGCCGTTTGCATTCTCTTTAAAGAAATGCTGTTTGCTAATGACAATATTTGTGTTGAAACATTTCTGGGGTCATACTCTCTCCGTCTGCGATAACTGTTTGCTAATGACAATATTTGTGTTGAAACTTTGTAAGCTTGTTTAACTCTGTAGATGCAAATCCAGTTTGCTAATGACAATATTTGTGTTGAAACTTTGCGTTTTCGACCATGGCGATTAGTCTATCTGTATCTCGGTTTGCTAATGACAAGATTTGTGTTGAAACTAACTTCGTCTCTTGCATATCCTGCAAAAAACATAGTTTGCTAATGACAATATTTGTATTAAAATAGCTTTTTTTGAAAGCTGTTTCTACTGCTAAAGTAACAGTTTGCTAATCACAAAGCTTGTATTAAAAT

>NZ_CP027287|3|3|726147-728154|PILER-CR
GTTTGCTAATGACAATATTTGTGTTGAAA	CTATTACTAGTTATATGGCTAGTATATCTGCTTCCT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTTTTTTTACTATAGCCCAAATAGCCGCTATTACGG
GTTTGCTAATGACAATATTTGTGTTGAAA	CTAAAACAAAAACAAAGGCTAAAATGATATACACAAG
GTTTGCTAATGACAATATTTGTGTTGAAA	CACTACAGGTACATTAGATATTTTTAAATCTAATGTT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTCTGTTACAAAGCCTACTTGCTTTAAGCCCTGGCT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTAAAATACCTTGACAAGTCTAAAATTTTATACTA
GTTTGCTAATGACAATATTTGTGTTGAAA	TTTGCTATTTGCAAATTTTGCAGGGACGGCTTTACCA
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTAGCTCTTGCGATGGCTTTATCAAAATTCATATTTA
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTTTTTCTTGCTGTGCGTTTAAAGCCTCTTGCTGT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTGTGGTAGCCCCCTGCTTAACCAGTTGTTCGAAAGTA
GTTTGCTAATGACAATATTTGTGTTGAAA	CAGTTTCCTACGCAGGACAAAAGAGCGCATACTCTGT
GTTTGCTAATGACAATATTTGTGTTGAAA	CGCGATTTTCTTTAATAAAATTAATCGCCTCGTCTG
GTTTGCTAATGACAATATTTGTGTTGAAA	CCAATTTTTAAAGATATTCTCCCCTAGATTTGATCC
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTAAAAGATAGGAAGCAATTTACAGAGGAAAAAA
GTTTGCTAATGACAATATTTGTGTTGAAA	CATCTCTATGGCTTTGCTTTCTTTTAATGGATCTAC
GTTTGCTAATGACAATATTTGTGTTGAAA	CGAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCT
GTTTGCTAATGACAAGATTTGTGTTGAAA	CACTTTTTTCACTTCAGTTATTGTAGTCATTCCAGGG
GTTTGCTAATGACAATATTTGTGTTGAAA	TTTGCCTTGTGTTAGTCTTATGGTTATTTGGTTAGAA
GTTTGCTAATGACAATATTTGTGTTGAAA	CATAATTATTGAAGAATATTTTTGTTTTAGACTTCT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTGCAGACTTTCCACTCTACTTTGTCTTGTTTGCCATT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCC
GTTTGCTAATGACAAGATTTGTGTTGAAA	CAAGATTTCTATTAATAATCAAATTTTAGAGGAACAA
GTTTGCTAATGACAATATTTGTGTTGAAA	CGGCGAAGGACACTGTTGATAAAGGCATAGCTAGTGG
GTTTGCTAATGACAATATTTGTGTTGAAA	CCTTTGATGATAACTTTTTGGCTCTTTTGTGTGATAT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCC
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTAAAAATTGCCGTTTGCATTCTCTTTAAAGAAATGCT
GTTTGCTAATGACAATATTTGTGTTGAAA	CATTTCTGGGGTCATACTCTCTCCGTCTGCGATAACT
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTTGTAAGCTTGTTTAACTCTGTAGATGCAAATCCA
GTTTGCTAATGACAATATTTGTGTTGAAA	CTTTGCGTTTTCGACCATGGCGATTAGTCTATCTGTATCTCG
GTTTGCTAATGACAAGATTTGTGTTGAAA	CTAACTTCGTCTCTTGCATATCCTGCAAAAAACATA
GTTTGCTAATGACAATATTTGTATTAAAA

>NZ_CP027287|3|3|726147-728223|CRISPRCasFinder
GTTTGCTAATGACAATATTTGTGTTGAAAC	TATTACTAGTTATATGGCTAGTATATCTGCTTCCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTTTACTATAGCCCAAATAGCCGCTATTACGG
GTTTGCTAATGACAATATTTGTGTTGAAAC	TAAAACAAAAACAAAGGCTAAAATGATATACACAAG
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTACAGGTACATTAGATATTTTTAAATCTAATGTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TCTGTTACAAAGCCTACTTGCTTTAAGCCCTGGCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAAATACCTTGACAAGTCTAAAATTTTATACTA
GTTTGCTAATGACAATATTTGTGTTGAAAT	TTGCTATTTGCAAATTTTGCAGGGACGGCTTTACCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAGCTCTTGCGATGGCTTTATCAAAATTCATATTTA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTCTTGCTGTGCGTTTAAAGCCTCTTGCTGT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTGGTAGCCCCCTGCTTAACCAGTTGTTCGAAAGTA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGTTTCCTACGCAGGACAAAAGAGCGCATACTCTGT
GTTTGCTAATGACAATATTTGTGTTGAAAC	GCGATTTTCTTTAATAAAATTAATCGCCTCGTCTG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CAATTTTTAAAGATATTCTCCCCTAGATTTGATCC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAAAGATAGGAAGCAATTTACAGAGGAAAAAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATCTCTATGGCTTTGCTTTCTTTTAATGGATCTAC
GTTTGCTAATGACAATATTTGTGTTGAAAC	GAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ACTTTTTTCACTTCAGTTATTGTAGTCATTCCAGGG
GTTTGCTAATGACAATATTTGTGTTGAAAT	TTGCCTTGTGTTAGTCTTATGGTTATTTGGTTAGAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATAATTATTGAAGAATATTTTTGTTTTAGACTTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGCAGACTTTCCACTCTACTTTGTCTTGTTTGCCATT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AAGATTTCTATTAATAATCAAATTTTAGAGGAACAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	GGCGAAGGACACTGTTGATAAAGGCATAGCTAGTGG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTTTGATGATAACTTTTTGGCTCTTTTGTGTGATAT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAAAAATTGCCGTTTGCATTCTCTTTAAAGAAATGCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATTTCTGGGGTCATACTCTCTCCGTCTGCGATAACT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTGTAAGCTTGTTTAACTCTGTAGATGCAAATCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTGCGTTTTCGACCATGGCGATTAGTCTATCTGTATCTCG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAACTTCGTCTCTTGCATATCCTGCAAAAAACATA
GTTTGCTAATGACAATATTTGTATTAAAAT	AGCTTTTTTTGAAAGCTGTTTCTACTGCTAAAGTAACA
GTTTGCTAATCACAAAGCTTGTATTAAAAT

>NZ_CP027287|3|3|726147-728223|CRT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TATTACTAGTTATATGGCTAGTATATCTGCTTCCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTTTACTATAGCCCAAATAGCCGCTATTACGG
GTTTGCTAATGACAATATTTGTGTTGAAAC	TAAAACAAAAACAAAGGCTAAAATGATATACACAAG
GTTTGCTAATGACAATATTTGTGTTGAAAC	ACTACAGGTACATTAGATATTTTTAAATCTAATGTT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TCTGTTACAAAGCCTACTTGCTTTAAGCCCTGGCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAAATACCTTGACAAGTCTAAAATTTTATACTA
GTTTGCTAATGACAATATTTGTGTTGAAAT	TTGCTATTTGCAAATTTTGCAGGGACGGCTTTACCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAGCTCTTGCGATGGCTTTATCAAAATTCATATTTA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTTTTCTTGCTGTGCGTTTAAAGCCTCTTGCTGT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TGTGGTAGCCCCCTGCTTAACCAGTTGTTCGAAAGTA
GTTTGCTAATGACAATATTTGTGTTGAAAC	AGTTTCCTACGCAGGACAAAAGAGCGCATACTCTGT
GTTTGCTAATGACAATATTTGTGTTGAAAC	GCGATTTTCTTTAATAAAATTAATCGCCTCGTCTG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CAATTTTTAAAGATATTCTCCCCTAGATTTGATCC
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTAAAAGATAGGAAGCAATTTACAGAGGAAAAAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATCTCTATGGCTTTGCTTTCTTTTAATGGATCTAC
GTTTGCTAATGACAATATTTGTGTTGAAAC	GAAAATAAGTTAGTTAAACATAATTTTAAAGAGTCT
GTTTGCTAATGACAAGATTTGTGTTGAAAC	ACTTTTTTCACTTCAGTTATTGTAGTCATTCCAGGG
GTTTGCTAATGACAATATTTGTGTTGAAAT	TTGCCTTGTGTTAGTCTTATGGTTATTTGGTTAGAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATAATTATTGAAGAATATTTTTGTTTTAGACTTCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTGCAGACTTTCCACTCTACTTTGTCTTGTTTGCCATT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	AAGATTTCTATTAATAATCAAATTTTAGAGGAACAA
GTTTGCTAATGACAATATTTGTGTTGAAAC	GGCGAAGGACACTGTTGATAAAGGCATAGCTAGTGG
GTTTGCTAATGACAATATTTGTGTTGAAAC	CTTTGATGATAACTTTTTGGCTCTTTTGTGTGATAT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TCTTCTGCGCAGTCTATGTAATTTTTTACATTTTCC
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAAAAATTGCCGTTTGCATTCTCTTTAAAGAAATGCT
GTTTGCTAATGACAATATTTGTGTTGAAAC	ATTTCTGGGGTCATACTCTCTCCGTCTGCGATAACT
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTGTAAGCTTGTTTAACTCTGTAGATGCAAATCCA
GTTTGCTAATGACAATATTTGTGTTGAAAC	TTTGCGTTTTCGACCATGGCGATTAGTCTATCTGTATCTCG
GTTTGCTAATGACAAGATTTGTGTTGAAAC	TAACTTCGTCTCTTGCATATCCTGCAAAAAACATA
GTTTGCTAATGACAATATTTGTATTAAAAT	AGCTTTTTTTGAAAGCTGTTTCTACTGCTAAAGTAACA
GTTTGCTAATCACAAAGCTTGTATTAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027287.1\|WP_065840439.1\|728744_729059_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_105459456.1\|731653_731890_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_158676889.1\|728418_728769_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173832
NZ_CP027287.1\|WP_065840343.1\|719711_720653_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP027287.1\|WP_065839032.1\|733517_734291_+\|pyridoxine-5'-phosphate-synthase	unknown	unknown	gnl\|CDD\|235380
NZ_CP027287.1\|WP_065838927.1\|716086_716455_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_065840345.1\|717330_718047_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP027287.1\|WP_023384789.1\|725280_725580_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP027287.1\|WP_058909205.1\|723788_724274_+\|Dna2/Cas4-domain-containing-protein	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP027287.1\|WP_065841535.1\|734287_735211_+\|4-hydroxythreonine-4-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|179681
NZ_CP027287.1\|WP_023384796.1\|730201_731647_+\|acetyl-CoA-carboxylase-subunit-A	unknown	unknown	gnl\|CDD\|169452
NZ_CP027287.1\|WP_023384799.1\|732648_733473_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|236352
NZ_CP027287.1\|WP_158004735.1\|721401_723792_+\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP027287.1\|WP_023384787.1\|724282_725284_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP027287.1\|WP_058909677.1\|720652_721414_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP027287.1\|WP_023384802.1\|735276_736827_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|223383
NZ_CP027287.1\|WP_039362197.1\|731876_732593_+\|arginyltransferase	unknown	unknown	gnl\|CDD\|234939
NZ_CP027287.1\|WP_023384778.1\|718036_719728_+\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
NZ_CP027287.1\|WP_058909679.1\|729245_729461_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_065838926.1\|716430_716745_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP027287.1\|WP_023384796.1\|730201_731647_+\|acetyl-CoA-carboxylase-subunit-A	gnl\|CDD\|169452	PRK08463, PRK08463, acetyl-CoA carboxylase subunit A; Validated.	0
NZ_CP027287.1\|WP_065840343.1\|719711_720653_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.41874e-37
NZ_CP027287.1\|WP_065839032.1\|733517_734291_+\|pyridoxine-5'-phosphate-synthase	gnl\|CDD\|235380	PRK05265, PRK05265, pyridoxine 5'-phosphate synthase; Provisional.	2.77543e-116
NZ_CP027287.1\|WP_065840345.1\|717330_718047_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.13307e-14
NZ_CP027287.1\|WP_023384789.1\|725280_725580_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.43889e-17
NZ_CP027287.1\|WP_058909205.1\|723788_724274_+\|Dna2/Cas4-domain-containing-protein	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	8.19216e-56
NZ_CP027287.1\|WP_065841535.1\|734287_735211_+\|4-hydroxythreonine-4-phosphate-dehydrogenase	gnl\|CDD\|179681	PRK03946, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional.	0
NZ_CP027287.1\|WP_023384799.1\|732648_733473_+\|adenylosuccinate-lyase	gnl\|CDD\|236352	PRK08937, PRK08937, adenylosuccinate lyase; Provisional.	1.40024e-16
NZ_CP027287.1\|WP_158004735.1\|721401_723792_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	8.62714e-29
NZ_CP027287.1\|WP_158676889.1\|728418_728769_+\|hypothetical-protein	gnl\|CDD\|173832	cd00684, Terpene_cyclase_plant_C1, Plant Terpene Cyclases, Class 1. This CD includes a diverse group of monomeric plant terpene cyclases (Tspa-Tspf) that convert the acyclic isoprenoid diphosphates, geranyl diphosphate (GPP), farnesyl diphosphate (FPP), or geranylgeranyl diphosphate (GGPP) into cyclic monoterpenes, diterpenes, or sesquiterpenes, respectively; a few form acyclic species. Terpnoid cyclases are soluble enzymes localized to the cytosol (sesquiterpene synthases) or plastids (mono- and diterpene synthases). All monoterpene and diterpene synthases have restrict substrate specificity, however, some sesquiterpene synthases can accept both FPP and GPP. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions located on opposite walls. These residues mediate binding of prenyl diphosphates, via bridging Mg2+ ions (K+ preferred by gymnosperm cyclases), inducing conformational changes such that an N-terminal region forms a cap over the catalytic core. Loss of diphosphate from the enzyme-bound substrate (GPP, FPP, or GGPP) results in an allylic carbocation that electrophilically attacks a double bond further down the terpene chain to effect the first ring closure. Unlike monoterpene, sesquiterene, and macrocyclic diterpenes synthases, which undergo substrate ionization by diphosphate ester scission, Tpsc-like diterpene synthases catalyze cyclization reactions by an initial protonation step producing a copalyl diphosphate intermediate. These enzymes lack the aspartate-rich sequences mentioned above. Most diterpene synthases have an N-terminal, internal element (approx 210 aa) whose function is unknown.	0.00706777
NZ_CP027287.1\|WP_058909677.1\|720652_721414_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.99727e-35
NZ_CP027287.1\|WP_023384802.1\|735276_736827_+\|inorganic-phosphate-transporter	gnl\|CDD\|223383	COG0306, PitA, Phosphate/sulphate permeases [Inorganic ion transport and metabolism].	1.5131e-49
NZ_CP027287.1\|WP_039362197.1\|731876_732593_+\|arginyltransferase	gnl\|CDD\|234939	PRK01305, PRK01305, arginyl-tRNA-protein transferase; Provisional.	3.33747e-89
NZ_CP027287.1\|WP_023384787.1\|724282_725284_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.63336e-139

>NZ_CP027287.1|WP_023384789.1|725280_725580_+|CRISPR-associated-endonuclease-Cas2
MTNYNYAYVFYDISDKESEAGKRRVAKVFKLCKKYFLHHQKSVFKGEITPSNFIKFKSAVEKLIDKNIDVITILRLIRKDDIDEMTLGGLDFVKNEMFL
>NZ_CP027287.1|WP_023384787.1|724282_725284_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MPKLHTRYIFSMGELSRKDNSLAFKNEKGTTYIPIVGIREIYCMNEVSMNSKLFDFLAKNGITIHFFNYYGNYSGSFYPKKHLISGRIITSQVEALATRNIIAKSIVKGIALNMHEVLYHYYRHGKTELKPLLDYLKLKVPNMLINANTIPQIMFIEGQIWSKFYDSFELFLDESFSLAKRVKRPPDNPMNAMISFGNSLLYTKTISAIYQTHLEQSISYLHESSDARFSLSLDLSEVFKPIIVFKTVFELINLKKINIKKHFEKKVEFCLLNEAGRKIFVESFEERLNESFLHSKLGRKVSYKTALKLEGYKLIKFICEAREFIPFSLKDKR
>NZ_CP027287.1|WP_058909205.1|723788_724274_+|Dna2/Cas4-domain-containing-protein
MKITGTLINYFFHCKRQCYLFYNRINLEDNSEDVKIGKVLHEIKFEDEIKFENIALDKITDEYVIEFKKSDSDETASMWQLLFYLKKLKEIGIFRKGLLEFGENRNLPTKRLKVELTTHKELELEQIYSQISELMSLKTPPDPLKSSLKCKKCAYFNYCFI
>NZ_CP027287.1|WP_158004735.1|721401_723792_+|CRISPR-associated-helicase-Cas3'
MLLLNIYLAHTAPNKDPETLQAHCDLTKEYLQKIKNSKNLNDIIKNLANQILNDDVILEFFDDFIINHDLGKMNPAFQRFKMENKEFNEASGESTHSNHSFNKLKDKYRDFFSNSTDQDIDKIICVFYYLLSNVLNHHGHLKDGFDDKYLKISDKEEDFDRLDKKFYNSRMRIDFDFELFILIKLHFSLLIASDFYATSEYMNDIKIDDFGVFDKDKKEIIYSKFREFYSSLKPRSDIDILRSDIFQKSSKTLYDNLDKNIFYLEAPTGSGKTLTSLNLALNLLNLNSNLNKIFYVFPFNTLISQSKSIFESIFGDEFDISVINSITPPKFNKGNDQENSESKYDKTYINRVFYNHPFILTSHVALFKTLFGISKEENYGLFSLANSVIILDEIQSYRSNLWEFMALFFDSFAKHLNIKFIIMSATLPKISNLLKNNDDKWCDLLANSNYFQNTLFKDRVKVDFSLLEIGQDELFETIVSKIKEHKKDKILVEFIKKSSARDFYNFIRFKFDGYDIFELSGDDNKLYQKIVIAKLKNSNTKAIVVATQVIEAGVDIDMDIGFKDIATFESEEQFLGRINRSALKPGSLAYFFDYDNASMIYKNDSRIKFSLKDDGLKKCLIDKNFNPYYEKLLYELKCENSRVNGGFNSVRENFQKYISSINFIKISENMQLINDDRVRIFLPFKIDVSDFDMSEYGDVEHFMDGNFLDGKKIWEAIICLNEVKEYGKRKIEALSLNSLADIFSFNVFMVDDLLSISSQMRYGYIYIEDCDGFIDENGKFDRTAFAKKFNNEDLLL
>NZ_CP027287.1|WP_058909677.1|720652_721414_+|type-I-B-CRISPR-associated-protein-Cas5
MKAISFKLSGKFAHFKKPDVNEYVYFTYNNIPKPTLLGLLGAIIGLKGYAQKTYNNKKDKKSLLNNENRSNEPEFYERLKHLKICIIPLVKYGKFSKKIQVFNNSVGYASTEEGGNLIVREQWLENPSWQILIEDDGSAEFETISQYLFDKKAKFIPYLGKNDHFADISEVEKIDLAESKKDKIVIKSLFLDNLAKQVDDPDDEISYLFNEFYPIGFNELMFYKLEKTTFTNQICQAMDGKWYEFKDGTICFF
>NZ_CP027287.1|WP_065840343.1|719711_720653_+|CRISPR-associated-protein
MKLANRIYGIIGIKSTMANWNADFSGRPKSTGNGDIFASDKALKYPMKKMWESYGKNILFVKSLKQGKSKDGNDKLVPNTLGERYGLLFGDIKKAKSTKEVLSNLFNCIDVKNFGATFPEDGYNLSITGAVQIGQGFNKFGDINIEVQNILSPFADSRAKEKNENGEDASQSTLGTKIVTDEAHYFYGFCINPLAYNDYKEILGDDFGYNEDDYAEFKKAARFCATYFNSNSKFGCENEFAMFIETAVDAYLPDLSSYMDFICKDKNRSVNLEKIEKMIESSDVKKVEIYYNPLSLDVETKFDKFDIYSGNKI
>NZ_CP027287.1|WP_023384778.1|718036_719728_+|hypothetical-protein
MLFELLDEFKKQLEKNKHIVTQNHILKDGVYARISDEKCEIFYVKTITEKIGKTAQKRTILYKQNGDIALNDDMQWFEQADYLSFLWDMNKAVLPNKKFHSINFLSLFFKLEESEYVKENLEEYFDIFRDYSAFNKAKDKEILSFYMDYIKDENRQNLITNSVVLSKKYFNDINDFAVQNNFKKCYIKFFIDKDFEIYEKESQIYIDLKIYNSNEHNIKYNNEIFGLSNFNMGMNSKKPFLEHKNRLFKIPYAISQKDALASKMLFDWLGSQNKRIIRDFNSIFISKFNKQSKAVVSDFEYVPVDKNKFKFDKFKLKNFMNIENGEKEILSFDDFKQVIDEQLYHKCLFGNLYNDEIRVSKRISEDMQNLLYQTRCSMVEYFDKFNNNEFYYVIQKYSNDFIKIAMQDSEFGRLNGKKSINLLLSIKEIKGEKVDIDGIKNRVISALTDDNVTKLSGNEYYFLVGNLAMYLVSKSKTWKKTFALTDPYTKARNTKKLKMALFIDFDRYNYDIFLENGILKKAFSLAQNCEDIVMSNNDQQMVLIGMMTKNIIKKPGEKDEISE
>NZ_CP027287.1|WP_065840345.1|717330_718047_+|CRISPR-associated-endoribonuclease-Cas6
MKIYQLKVFLKLNQNVDFINSPEFLSTNLHKAMLGDEALRSIHMQRYLKPYSIGFLYSMKGKKDTFVSGEDMYFYVRSIDESFISKLRICLENSKNLGFNVHSSKLEHLDIKQIDRLYTMSPATIVLKEGDKTIPWRRENSDITVLKEALISNLKNKYEYFLDKKIEIKDDIIELIEIKTNRAFAFRYKNGKIYAYRYQIHFSQNRLAQEFANIAMILGIGVKNTLGFGFCMRSNNAV
>NZ_CP027287.1|WP_065838926.1|716430_716745_+|hypothetical-protein
MENRKLIIGYYGIEWDIKVPGYDEDKADVLKIIKPITSVMDGKIVEVFDILTPHKEDIDDAKEYKEFYEICDFEVPQTNHKFTGTFIDALEYIKDTFNQVSKTV
>NZ_CP027287.1|WP_065838927.1|716086_716455_+|hypothetical-protein
MKNTSPLSKDEAVKHIDKTGVERVLSKQNYFGENNHSKPLYKRVPKSDVVKALNSINTMAKNKDNKYINAFSDNGYFIVFNGNEIVTCYKHKDGNKATFNYFKSASIYDKKEVIKWKIANLL
>NZ_CP027287.1|WP_158676889.1|728418_728769_+|hypothetical-protein
MKNTSPLSKDEAVKHIDKTGVERVWKKSNTHIYEKHDTEPKDVVKALNSINTMAKNKDNKYINAFSDNGYFIVFNGNEIVTCFKHKDGNKATFNYFKNASIYDKKEVIKWKIANLL
>NZ_CP027287.1|WP_065840439.1|728744_729059_+|hypothetical-protein
MENRKLIIEFLGIEWFIEIPDYDDKVTKGLGIIAPITSVKNGKIARIFDIFAPETECINEAKEHKEFYEICDFEVPQTNHKFTGTFIDALEYIKDTFNQVSKTV
>NZ_CP027287.1|WP_058909679.1|729245_729461_+|hypothetical-protein
MSPEEFGLSQYERMLLGGLNLSAGFEVGFGASYCKCDSLVLKEYCKNCGIDFLWAYSIFKRYANVLNKVED
>NZ_CP027287.1|WP_023384796.1|730201_731647_+|acetyl-CoA-carboxylase-subunit-A
MIHKILIANRGEIAVRIVRACKDLHIKNVAIYTEPDRECLHVKVADEAYQIGKDPIKGYLDSKRIVEVAKACGADAIHPGYGFLSENYEFAKEVEDAGLIFIGPNSDIIRKMGNKNIARFLMKKNGIPVVPGTEKLNSETIETIKDYAMKIGYPVILKASGGGGGRGIREVWNEDELESNYESCKREAKAFFNNDEVFMEKFIEKPRHIEFQILGDNYGNLIHLCERDCSIQRRHQKVIEIAPCPTISEDLRKRMGVAAVAAAKAVGYTNAGTIEFLLDDYNNFYFMEMNTRIQVEHGVTEEITGVDLISRQIRIAAGEILDIEQSEVRPQGVSIEARITAENVWKNFAPSPGRITGYFPALGPGVRVDSHIYQDYAIPPFYDSLVAKLIVKGTSYDLAVSKLERALDEFKIEGVRTTLPFLLAISKRRHFRRGFFDTSYIEERLQDILENTQDHHQENKEEVIAAIAAAIKKVKEDRAKE
>NZ_CP027287.1|WP_105459456.1|731653_731890_+|hypothetical-protein
MNDFLDSLKNIKNELVKEQKSQEVKVPKKPKPNPNRDEFKDIFTEPNEIEMPDAKEHRLKDEFLEFIKHSDVKKLERD
>NZ_CP027287.1|WP_039362197.1|731876_732593_+|arginyltransferase
MREIDFCTLDTLCPYLKDRNSRSMYRYVSQCSFDYNSNLVKHGYRRFGSYFSKPVCDGCDECKSIRIDAFNFKFTKSHRRIINKNSNTKIVVSKPYISQKHIDLYEKYHKFMHEKRGWEYYDLDFRRYYSVYVEGAGDFGYEIDYFVDDELVCVDLVDIVDDGISSIYCYWDIDFAHLSLGKFSLLNQIKIALKNDLRWIYLGFYVKDCASLAYKGEYKPYETLKKYCDMDEKPIWEF
>NZ_CP027287.1|WP_023384799.1|732648_733473_+|adenylosuccinate-lyase
MQITQTLESITITTDDCDLFLNLSNKIRQSFANAIGNRDKVIIFYNENELVQRKYFLKLIGKIYANSVGKGIDFLLTHHKNIKLVYKKPNSLQILINVDVKFENSRVVFDLKNSEELFTKYLIRGLGDTRHEYFESKKILVISPKTTENVELLDNILNFREHLKYIVNFNYDKKSYDEFKKRAKILTSKTYIRRFSMLANLLEEHFETLGCKATDDFETVRTNYLNLTKVYHPDKHVGEPNEVQKSYIDKFQKIGLAYEALKPYFKEQKSFISA
>NZ_CP027287.1|WP_065839032.1|733517_734291_+|pyridoxine-5'-phosphate-synthase
MKLGVNIDHVAVLREARAVNDPQIIHAMFEAVSGGADQITIHLREDRRHINEDDVKNIINLSPIPVNLECSISSEIIDIVCALKPHRATIVPEKREELTTEGGLSLDSLNLKNVISKLNDNDIKVSLFIDPKKNDVTVSKELGATCVELHTGAYANTFLMLNSNLNHTKYKIDSLNLKRSELEILLNSELTRIKEAANLGINLGLEVAAGHGLNYQNVTAIAAIKDIFELNIGQSIVAKSVFVGLKNAVKEMMELVK
>NZ_CP027287.1|WP_065841535.1|734287_735211_+|4-hydroxythreonine-4-phosphate-dehydrogenase
MNLPKIAISVGDINGVGIEIALKSHNEIKNICSPVYFINNELLNSAANILKFTIPNDFEIFECGNSFNIKPGHVSKKSGKFSFVSFQNALLYTQNKHAQALVTMPINKESWKKAGVPYVGHTDALGKYFGKNAIMMLGCEELFVALYTDHLALKDVSAKIKAKNLALFLVDFYNSSKFENIGVLGFNPHASDNETIGGKEEKEIIKSIKLANNRLKKEVFTGPLVPDAAFTKSSLKRCNRLVSMYHDVGLAPLKALYFDKSINVSLNLPIVRTSVDHGTAFDIAYKGKAEIKSYIEAIKFAIKSCGY
>NZ_CP027287.1|WP_023384802.1|735276_736827_+|inorganic-phosphate-transporter
MSRDNRDNLFALIFFIISVVAFFMWGYNYIPSNHLLLFILASIFGLFMAFNIGGNDVANSFGTSVGAKTLTLKQALIIAAVFELSGAVFAGAEVTNTIRSGIVSLPKGDVNPMVFVIIMISALFSSGAWLFIATKKGLPVSTTHSIVGGIVGAGMMMGFIYYNGSKTFDMVQWSEIGRIALSWVISPVMGGVMAYLIFGYIKSKIIIPSSRIQSEIKSLKRARKTYKDQYIKELSNKSEAEQIKELRRIAIIDEDECEGENCDFRDKIKAMKEEEKNIDGTVFMRTHIPIVAGVAAMIIAGSMLFKGLKHMDFNLSIIQTIWIIFVIGIAAYLASFAMVNLMKKDNPQKGINRIFGWFQIFTASSFAFSHGANDIANAVGPFAAILDVLKNNTINETTPIPSIAMATFGIALVVGLWFLGKEVIATVGTKLAEILPTTGFSAELASSIVILIATKMGLPISSTHVLIGAVLGIGVYNRNANWGMLKPIGLAWVITIPISMIGSAIGFLAIKNIMGL

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Crispr_ID: NZ_CP027287_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027287_4

1105575-1105709

Orphan

Consensus_repeat	Method
ATTTTATCATTTATGATGATCTAGGAAATAATATAGAAAATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP027287_4

>merge|NZ_CP027287|4|1105575-1105709|CRISPRCasFinder
ATTTTATCATTTATGATGATCTAGGAAATAATATAGAAAATATTGAAAAAGAAATAGTTGATAACAAAAGAAATTTTTTTAGTTTTAATGATGATTTTATCATTTATGATGATCTAGGAAATAATATAGAAAATA

>NZ_CP027287|4|4|1105575-1105709|CRISPRCasFinder
ATTTTATCATTTATGATGATCTAGGAAATAATATAGAAAATA	TTGAAAAAGAAATAGTTGATAACAAAAGAAATTTTTTTAGTTTTAATGATG
ATTTTATCATTTATGATGATCTAGGAAATAATATAGAAAATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027287.1\|WP_105459516.1\|1116359_1117028_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379233
NZ_CP027287.1\|WP_105459510.1\|1108616_1109615_+\|restriction-endonuclease-subunit-M	unknown	unknown	gnl\|CDD\|372662
NZ_CP027287.1\|WP_032582765.1\|1112648_1114568_+\|tetracycline-resistance-ribosomal-protection-protein-Tet(O)	unknown	unknown	gnl\|CDD\|206731
NZ_CP027287.1\|WP_105459515.1\|1115478_1116402_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP027287.1\|WP_105459511.1\|1109661_1109904_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_002779755.1\|1114619_1114793_+\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|379503
NZ_CP027287.1\|WP_105459506.1\|1101763_1102963_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377390
NZ_CP027287.1\|WP_105459502.1\|1097782_1098217_+\|plasmid-mobilization-relaxosome-protein-MobC	unknown	unknown	gnl\|CDD\|368576
NZ_CP027287.1\|WP_105459504.1\|1100549_1101383_+\|DUF1738-domain-containing-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_105459501.1\|1096841_1097786_+\|Flp-pilus-assembly-complex-ATPase-component	unknown	unknown	gnl\|CDD\|274301
NZ_CP027287.1\|WP_105459513.1\|1110542_1111193_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|222854
NZ_CP027287.1\|WP_158004709.1\|1112081_1112234_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_105459507.1\|1102981_1103554_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379235
NZ_CP027287.1\|WP_024305372.1\|1096618_1096840_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_105459500.1\|1095390_1096605_+\|TrbI/VirB10-family-protein	unknown	unknown	gnl\|CDD\|319755
NZ_CP027287.1\|WP_105459503.1\|1098209_1100126_+\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	unknown	unknown	gnl\|CDD\|226036
NZ_CP027287.1\|WP_064019608.1\|1111427_1111994_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_105459508.1\|1103550_1105512_+\|type-IA-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|223624
NZ_CP027287.1\|WP_059442986.1\|1111194_1111410_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_105459505.1\|1101439_1101715_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP027287.1\|WP_105459516.1\|1116359_1117028_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379233	pfam13518, HTH_28, Helix-turn-helix domain. This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	1.17967e-05
NZ_CP027287.1\|WP_105459510.1\|1108616_1109615_+\|restriction-endonuclease-subunit-M	gnl\|CDD\|372662	pfam13651, EcoRI_methylase, Adenine-specific methyltransferase EcoRI. This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.	3.04416e-90
NZ_CP027287.1\|WP_105459515.1\|1115478_1116402_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	6.44086e-46
NZ_CP027287.1\|WP_002779755.1\|1114619_1114793_+\|conjugal-transfer-protein	gnl\|CDD\|379503	pfam14205, Cys_rich_KTR, Cysteine-rich KTR. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length. There are 4 conserved cysteines and a conserved KTR sequence motif.	5.76382e-28
NZ_CP027287.1\|WP_032582765.1\|1112648_1114568_+\|tetracycline-resistance-ribosomal-protection-protein-Tet(O)	gnl\|CDD\|206731	cd04168, TetM_like, Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor site. This subfamily contains tetracycline resistance proteins that function through ribosomal protection and are typically found on mobile genetic elements, such as transposons or plasmids, and are often conjugative. Ribosomal protection proteins are homologous to the elongation factors EF-Tu and EF-G. EF-G and Tet(M) compete for binding on the ribosomes. Tet(M) has a higher affinity than EF-G, suggesting these two proteins may have overlapping binding sites and that Tet(M) must be released before EF-G can bind. Tet(M) and Tet(O) have been shown to have ribosome-dependent GTPase activity. These proteins are part of the GTP translation factor family, which includes EF-G, EF-Tu, EF2, LepA, and SelB.	1.07781e-143
NZ_CP027287.1\|WP_105459502.1\|1097782_1098217_+\|plasmid-mobilization-relaxosome-protein-MobC	gnl\|CDD\|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	0.0020962
NZ_CP027287.1\|WP_105459501.1\|1096841_1097786_+\|Flp-pilus-assembly-complex-ATPase-component	gnl\|CDD\|274301	TIGR02788, conjugal_transfer_protein, P-type DNA transfer ATPase VirB11. The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.	6.69773e-51
NZ_CP027287.1\|WP_105459513.1\|1110542_1111193_+\|AAA-family-ATPase	gnl\|CDD\|222854	PHA02518, PHA02518, ParA-like protein; Provisional.	9.51645e-37
NZ_CP027287.1\|WP_105459506.1\|1101763_1102963_+\|hypothetical-protein	gnl\|CDD\|377390	pfam04610, TrbL, TrbL/VirB6 plasmid conjugal transfer protein.	0.000275079
NZ_CP027287.1\|WP_105459507.1\|1102981_1103554_+\|AAA-family-ATPase	gnl\|CDD\|379235	pfam13521, AAA_28, AAA domain.	3.51881e-10
NZ_CP027287.1\|WP_105459500.1\|1095390_1096605_+\|TrbI/VirB10-family-protein	gnl\|CDD\|319755	cd16429, VirB10, VirB10 forms part of core complex in Type IV secretion system (T4SS). This family contains VirB10, a component of the type IV secretion system (T4SS), including homologs TrbI, TraF, TrwE and TraL. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both, the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TrwE in R33 plasmid has been shown to be anchored to the inner membrane and its C-terminal is necessary for conjugation; the transmembrane domains of TrwB and TrwE are involved in TrwB-TrwE interactions. TraF protein of the RP4 plasmid is involved in circularization of pilin subunits of P-type pili. In gonococcal genetic island (GGI) of Neisseria gonorrhoeae, T4SS encodes TrbI and circularization occurs via a covalent intermediate between the C terminus of putative pilin protein TraA and TrbI.	3.95458e-60
NZ_CP027287.1\|WP_105459503.1\|1098209_1100126_+\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	gnl\|CDD\|226036	COG3505, VirD4, Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion].	3.97289e-64
NZ_CP027287.1\|WP_105459508.1\|1103550_1105512_+\|type-IA-DNA-topoisomerase	gnl\|CDD\|223624	COG0550, TopA, Topoisomerase IA [DNA replication, recombination, and repair].	5.70802e-134

>NZ_CP027287.1|WP_105459508.1|1103550_1105512_+|type-IA-DNA-topoisomerase
MNENTIIIIESPNKCDKIEHITGAKVYATKGHFKELTNEIVADYKSYEPIFDFKEASKSRINAMFNDCKGKDVIIATDPDREGYGIGYMVYDTIKNIAKSVKRAEFHEITESGIKKGLERAVPFASSNLKEFDSFKARAVGDKLVGFIMSPTYINKLNDKNNSVGRVQTPALALIVKRELEIKEFNENKANAKIDYKIKAKLKTKDGVEFTAINDNIFKSKDEANAKISDLNGSLAKVYQIETKEAQTKPKPPFRTSQLQEIANKKLGFSSDKTMSLAQKLFEKGLITYHRTDSNSLSNEFIDEVGAKFGNEEWYEKREYKAGSQSQAEAHEAVRISHVHEYGDLEAIAKKESLTDDEKALYELIFLNSIQSQAKNAINENTIYDIDIKTLSFKAKTSKCVYKGFKNAIVAANDDDDEKDKEAQEIALNLAKGDELEILEFSLQEVKKQAPQHYKESNFISLLEKEGIGRPSTYATFLPTLLKREYVVIETKGKNSNIIATPKGINFIQTLKANDDDWITQSEFTKQMENVLDEISSGKVSYLDFIKPLHEKMGFKELNNGGDTKPPSEKQLEWARNIAKDLNISLPSDIADNWKICSDFIEKNKDKVVTMPSEKQIELAKKLSKDKGLALPKGYDTNLKICKEFIDKAIKKK
>NZ_CP027287.1|WP_105459507.1|1102981_1103554_+|AAA-family-ATPase
MNKLVINIYGSPGAGKSTLAKNLKKYMREKRIDVGLISEFATELIENNQKEKLKDQPYVTKGQMLNIAKVLKEHDIAISDSPIELGKFYCDPRDEQRTNELIKKCKNMYKSINFFLKLDEQSKQDYTMESRVHTYAQSQKLQERMLASSILRDETFMIIDRNTQIKEVLKMIEKSKQWKEHQNQSKGLEL
>NZ_CP027287.1|WP_105459506.1|1101763_1102963_+|hypothetical-protein
MAQTQVAKDLLTDSNWINKTQNIIQENVMSLFEKFYQGAHDLVYSTATTTIVILIVSLWLLNRLKNGYPTRNEIFVAVKYIIQLCFIFAILSSFDAYQGILYALTIPENVIITILSSIFEGRDFGAIVTESANRVDNIRALMWNYGTTEYLKTQAWSFLGISFNGVMDYLGAGIITALSMIPFWIFYIVFFLLLVGITIVIFFSKFMAFLILSTLPLVIPFLIIPRFLPYLWSWYKLYLSYAIIAPLAFIALNLAINPILELENYQNYISELFVKQFEYLITGSITCISALFLLKKIPSWINAVLGTQMESGSGGVVGGVVAGAVASKTLLGGLARKATGGSFVGGALSSLGAASGANVAGQIASASIGAGANVAKDIGHGIGKTYEAYKKFKGGYVAP
>NZ_CP027287.1|WP_105459505.1|1101439_1101715_+|hypothetical-protein
MLNEFLNFLGFNKAACKKQLHTDNTDIKENVEMQEYIVEMQSPDFKEEITTETVIKDGKKIEIQKIKTTEPLNNGKTLITTKIYKKDITRM
>NZ_CP027287.1|WP_105459504.1|1100549_1101383_+|DUF1738-domain-containing-protein
MEQVRKSWEQMDNAEKKESFDKYMKFKLFEAHKTAKADWQRDMSKEEVDNTIPYNAKTGSTYSRETSMLLRAEMAIKGYEKPQFVTMEQGNAMGGVLKLKHDEQTGEVVKTKNGKDARVDGVKMLYITDHELRPKIDKDGKEVTAVVKDKDGNVKHDKETGMPITYVVKEKIPIKPRLETKTLYHVSQFDGLDQAQIKERDLEAIQAYREKAKSQDFEVKIDYGKTLGISGNLEKQLNNLTLAQIKGVDYYNPVQKVEMTKEKAQAKEQNKGIEQGR
>NZ_CP027287.1|WP_105459503.1|1098209_1100126_+|type-IV-secretory-system-conjugative-DNA-transfer-family-protein
MDDTQKFSTKKWIIIFISSLIMGVLAYLAMVKVIFNPDLVNVPAVAIKILNNIGSPMLKLKAYVALFALVAPFLVVVAWWLMPYFSDNENYGSARFATPDDFKKMSINYKNGLVLGCLNIDSENPKFLRATRPLATLVVAPPGSGKTAGMIIPNLLSIPNSSVTLDIKGELYQKTAGYRQKYFKNEIQLFSPFSWDNTLFFNPFDYSIVKDMEYIRIKKLADQIANTIFVAEKEKENDHWVLSAKTLFVFFAEYFMQKNKHTTLGELAQAPKADYFDILEDQFLEEALEQDEDDPEKPRKRDYDVDTFKIWLKQTANDTSIDESTRNQARAYSKAAENEFASIKSTYDTFMKVFSHPQVASATSKMSFAFEDLREKRISMYVVIQTEDMEILAPLIRIFIETLFKKLMSGKENSDPDKFIYCFLDEFVRFGKMPFLLEAPALCRSYGLLPVFVTQAYEQIKKYYGEDDMNIVKNNSGYHVIFGMNSEKDAKDTSELIGDYTNIKISKSQGNMDLFKSNISKSKEAKRLVTAQDLKNQDSNDIYILVSKFFKMPIKAKVPYWFKIAQFKGANEIEVKAIAQKEQTNTHKPQDTNILQNSPATAQQNSQKTNESKVEVADMDKQQRDELLKALKIKVDRE
>NZ_CP027287.1|WP_105459502.1|1097782_1098217_+|plasmid-mobilization-relaxosome-protein-MobC
MKKTRHHIYLTEADDRILRQLSDKRNQSRSAIVRKLLQTQKYKDNLKEIETNNRIISCYLKEFSHIGTNINQIAYHLNANITDHEEAKTDFEKNIVKLMQIVKELNEKIDTLKIKINVPHIKTPSNIKERDGIEEYEIKREENG
>NZ_CP027287.1|WP_105459501.1|1096841_1097786_+|Flp-pilus-assembly-complex-ATPase-component
MAESIILNNILGVLKPYLNLNANELIFNKPCEINVDYGDHWEIIQDQKLDAKFLNNFLIELATRRNQRFDESHCHLSCELPEPFLRYRVQAQHKSSLFNSEIAICIRIPSREIYPLESFILSEKCINDGWSYDKIKELIHKKKNILLSGGTGSGKTSFLNSLMGEIDPNERVVTIEDSQELRVENINKTQLAVPKIATEIYSYQVAIDNAMRLRPDRLFLGEIDIRNTFSFLRVNNTGHAGNLSTLHANSPRDAIKAIKTNVILGGGLSNVDDGMIDSLIITAIDYIIQITRVKNKRVVTDILNLKEDMGKIVA
>NZ_CP027287.1|WP_024305372.1|1096618_1096840_+|hypothetical-protein
MEYEIIKEQINAELQNKKTNDKLLEKIAIQLKKIEKAETVYLKEKAKLENLVAQKQNLSNGVTTKQVEQDKEE
>NZ_CP027287.1|WP_105459500.1|1095390_1096605_+|TrbI/VirB10-family-protein
MKKGNKKLFLSLATISILSAPLFANNQEEVLNLDDSSKSKQELDRQIRNLQNQADLSHLFENSKFPVDDYIYKAGKREPNQDQNLTQILKDFEKLDQKQKAQAADKNLIQPSQYAEQEQEEMTQHIKQKQEELQAQQEQLRQEITMDSQKAYKKRMQELIRAQILANRNNEVKSVNQNSSKFGVDGFSNQKSIDISTNEHRLYRTIRAGRMIPAILTTAISSDLSGIVTAQIEQDIYAAMGRAVLIPRGSKAIGFYTNNTKIGHERLEIRWREIITPQGINIMLTDALVADNMGMAGAIGAINNKYWERYGIAYSISTITNGIMLGIASKMNTNGSANNQYATEMYSNARSDISSIVQDIMQQQSQIKPTIEIRSGSRIFLVPTNHMWFAKPKNGEVLMQYFND
>NZ_CP027287.1|WP_105459510.1|1108616_1109615_+|restriction-endonuclease-subunit-M
MNHKNQLNQETNWMSNKEKKPNIYFMKAKYEIDDEFYTSYHEIKKELDDYKSHFKGKIVVCPCNDSRKSNFYKYFRINFKNLELKKLITTTFNINDVNLKGTKIEITNDSASETQLQGNGDFRSDEVKEIIAQGDIIVTNPPFSLFRDLIDIVESYNKKFLIVGGTYSITYKKIFELYEKGKIWLGNHQVCIFTRPNGTKKRFSNISWFTNLKSIKHLKPIKLTKKYKNNEHKYPEYDNYKVIEVTSYKDIPIDYYGIIGVPLTFFLRHNPAQFNILGCDFQIKEKYPELVKWDYKENNTKSAVLNGQEMFTRIIVQRKSGLMPRIRLQNQL
>NZ_CP027287.1|WP_105459511.1|1109661_1109904_+|hypothetical-protein
MKFEELEFSGLPDNFLCQKVCEIYKITNKELSDKLGIEIEVLNSLQDNDVRLPKSAKVALELMHIIDIWYNTDLIFSKNE
>NZ_CP027287.1|WP_105459513.1|1110542_1111193_+|AAA-family-ATPase
MIVSICNEKGGSGKSTLATNIAINQSLVKNELPLLIDTDPQKSIATFLNIRNEENNPKLFDFTYKYGENLKEFLQNYNSDKDVVIDTGGRDSREMRIAIALSDMVIIPTIPSQFDVSVLDKMVNVIKMAKEQNEKLVAYIVINRVSTNPFLYKKIESLRNFIEEMEQDYIKLAQTIIYERERYKVATQLGLGVVEIKDGNKTENEIKSLCKELLGD
>NZ_CP027287.1|WP_059442986.1|1111194_1111410_+|hypothetical-protein
MVEEIELTERLINAEKKLQAYETLFSCVSQEFYKYCESLKNDIEKEINKSIKNILIQRKKEIDNYISIIEL
>NZ_CP027287.1|WP_064019608.1|1111427_1111994_+|hypothetical-protein
MNFKKTTNSIENLDAFIDGADTQKDTSIDKKVSVVTKISKELSNKIKLKYPKMPLTKYIEQALMVKIPHINEDILLTICQQAEWFNTSIADFVRYKMGLMEAPEPNELNKNEEKLENKILYVSNDNKKIIKRNAENIGLSLYRYSEIKIKATYELKDIFTFEELMQFKAEAMNYDLELDEYIAMRIKG
>NZ_CP027287.1|WP_158004709.1|1112081_1112234_-|hypothetical-protein
MIEESNKTIEQIARESLHSLEMTFENFAIFGVCSLMIIGIVTALILSSTR
>NZ_CP027287.1|WP_032582765.1|1112648_1114568_+|tetracycline-resistance-ribosomal-protection-protein-Tet(O)
MKIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTRTDTMNLERQRGITIQTAVTSFQWEDVKVNIIDTPGHMDFLAEVYRSLSVLDGAVLLVSAKDGIQAQTRILFHALQIMKIPTIFFINKIDQEGIDLPMVYREMKAKLSSEIIVKQKVGQHPHINVTDNDDMEQWDAVIMGNDELLEKYMSWKPFKMSELEQEENRRFQNGTLFPVYHGSAKNNLGIRQLIEVIASKFYSSTPEGQSELCGQVFKIEYSEERQRLAYVRLYGGILHLRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLPQRERIENPLPMLQTTVEPSKPQQREMLLDALLEISDSDPLLQYYVDTTTHEIILSFLGNVQMEVICAILEEKYHVEAEIKEPTVIYMERPLRKAEYTIHIEVPPNPFWASVGLSIEPLPIGSGVQYESRVSLGYLNQSFQNAVMEGVLYGCEQGLYGWKVTDCKICFEYGLYYSPVSTPADFRLLSPIVLEQALKKAGTELLEPYLHFEIYAPQEYLSRAYHDAPRYCADIVSTQIKNDEVILKGEIPARCIQEYRNDLTSFTNGQGVCLTELKGYQPAIGKFICQPRRPNSRIDKVRHMFHKLA
>NZ_CP027287.1|WP_002779755.1|1114619_1114793_+|conjugal-transfer-protein
MMKCEWILCPVCGSKTRNKIRKDTVLENYPLYCPKCRQERLIKVDNLKITVIKEPDA
>NZ_CP027287.1|WP_105459515.1|1115478_1116402_-|IS3-family-transposase
MNKKVERIGRGSDLKLKFLAIKEVAFEYKYSIKFLCEVWKINRRSYYKWLHRTPSNREKENEIIKEKILEIYYSVNKIYGFRRITMNVNHQMNKNYNVKRIYRLMKDELNISSIIRRKKKKYIKTSAEYQSENILNRNFSAENPQQKVLTDITEFKYGKDKKIYLCATLDLYDRSILSYSFSNKADTKLVLEVLNNSFDSNLTTKRILHSDRGSQFRSLEYKSALEKLNITHSMSRVGKCIDNGPMEGLFGNIKVEKYYLKKYKTLSELEKDISEYIKFYNEERLQKNLGNRSPIEYRKFKEKNVDN
>NZ_CP027287.1|WP_105459516.1|1116359_1117028_-|helix-turn-helix-domain-containing-protein
MSNKVKFTPEQKMFFVLKFRELKISLAEFCRLYNVERTAIHRWSIKYDNEGLEGLKEIKKPTKYPSHVLINSVKDYLTGNFSMLQIVKIYNLSGDAVLRTWLKWYNTPKWNIKVGEFMAREKISKDKKIQLVLQYINKEKSAKEIATNNDITEGQLRDWARKYKIHGDNALDDKRGIRKDQSDLSQEEILKRKNKELEEKNRRLEAELLLIKKLKELEGGVI

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Crispr_ID: NZ_CP027287_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027287_5

1366281-1366372

Orphan

Consensus_repeat	Method
TCAAATTCTATAAATAATTTAAATTTAAATAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP027287_5

>merge|NZ_CP027287|5|1366281-1366372|CRISPRCasFinder
TCAAATTCTATAAATAATTTAAATTTAAATAACTCAAATAATTCAAACTCTATAAACAATTCAAATTCTATAAATAGTTTAAATTTAAATAA

>NZ_CP027287|5|5|1366281-1366372|CRISPRCasFinder
TCAAATTCTATAAATAATTTAAATTTAAATAA	CTCAAATAATTCAAACTCTATAAACAAT
TCAAATTCTATAAATAGTTTAAATTTAAATAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027287.1\|WP_002850076.1\|1355344_1355755_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_CP027287.1\|WP_039362678.1\|1361176_1362322_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341466
NZ_CP027287.1\|WP_065840262.1\|1371892_1373281_+\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_CP027287.1\|WP_141069927.1\|1376863_1377064_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP027287.1\|WP_065841333.1\|1357023_1358844_+\|invasion-protein-CiaB	unknown	unknown	unknown
NZ_CP027287.1\|WP_081299790.1\|1363366_1364161_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271333
NZ_CP027287.1\|WP_081302972.1\|1376500_1376749_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP027287.1\|WP_152819273.1\|1376265_1376484_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225723
NZ_CP027287.1\|WP_023385612.1\|1359748_1360048_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226331
NZ_CP027287.1\|WP_105459600.1\|1370034_1371609_+\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|236471
NZ_CP027287.1\|WP_039362667.1\|1355840_1356854_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|184456
NZ_CP027287.1\|WP_023385626.1\|1373447_1373681_+\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NZ_CP027287.1\|WP_023385614.1\|1360190_1361084_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NZ_CP027287.1\|WP_158676892.1\|1375911_1376067_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP027287.1\|WP_023385617.1\|1362388_1363243_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP027287.1\|WP_002850080.1\|1358954_1359257_+\|F0F1-ATP-synthase-subunit-C	unknown	unknown	gnl\|CDD\|181444
NZ_CP027287.1\|WP_065839422.1\|1366628_1368005_+\|sodium-dependent-transporter	unknown	unknown	gnl\|CDD\|271367
NZ_CP027287.1\|WP_065840263.1\|1368032_1369877_+\|biotin-attachment-protein	unknown	unknown	gnl\|CDD\|227349
NZ_CP027287.1\|WP_039362675.1\|1359388_1359721_+\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|235016
NZ_CP027287.1\|WP_065838939.1\|1373677_1375789_+\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447

Protein	Function_ID	Function_description	E-value
NZ_CP027287.1\|WP_002850076.1\|1355344_1355755_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	1.2503e-45
NZ_CP027287.1\|WP_039362678.1\|1361176_1362322_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341466	cd08187, BDH, Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. The butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway in anaerobic micro-organism. Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. Activity in the reverse direction is 50-fold lower than that in the forward direction. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Since members of this superfamily use different divalent ions, preferentially iron or zinc, it has been suggested to be renamed to family III metal-dependent polyol dehydrogenases. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3. The active site of YqhD contains a Zn metal, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.	3.54029e-177
NZ_CP027287.1\|WP_065840262.1\|1371892_1373281_+\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP027287.1\|WP_141069927.1\|1376863_1377064_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	9.07349e-10
NZ_CP027287.1\|WP_081299790.1\|1363366_1364161_+\|hypothetical-protein	gnl\|CDD\|271333	cd14963, NHL_like_5, Uncharacterized NHL-repeat domain in bacterial proteins. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	4.61674e-09
NZ_CP027287.1\|WP_081302972.1\|1376500_1376749_-\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	2.03341e-12
NZ_CP027287.1\|WP_152819273.1\|1376265_1376484_-\|hypothetical-protein	gnl\|CDD\|225723	COG3182, PiuB, Uncharacterized iron-regulated membrane protein [Function unknown].	3.07003e-06
NZ_CP027287.1\|WP_023385612.1\|1359748_1360048_-\|hypothetical-protein	gnl\|CDD\|226331	COG3809, COG3809, Uncharacterized protein conserved in bacteria [Function unknown].	2.90966e-24
NZ_CP027287.1\|WP_105459600.1\|1370034_1371609_+\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
NZ_CP027287.1\|WP_039362667.1\|1355840_1356854_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|184456	PRK14018, PRK14018, bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB.	3.44575e-147
NZ_CP027287.1\|WP_023385626.1\|1373447_1373681_+\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	4.06875e-11
NZ_CP027287.1\|WP_023385614.1\|1360190_1361084_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	3.62224e-41
NZ_CP027287.1\|WP_158676892.1\|1375911_1376067_-\|hypothetical-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	0.00138617
NZ_CP027287.1\|WP_023385617.1\|1362388_1363243_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.50593e-21
NZ_CP027287.1\|WP_002850080.1\|1358954_1359257_+\|F0F1-ATP-synthase-subunit-C	gnl\|CDD\|181444	PRK08482, PRK08482, F0F1 ATP synthase subunit C; Validated.	1.01528e-37
NZ_CP027287.1\|WP_065839422.1\|1366628_1368005_+\|sodium-dependent-transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	9.08193e-138
NZ_CP027287.1\|WP_065840263.1\|1368032_1369877_+\|biotin-attachment-protein	gnl\|CDD\|227349	COG5016, COG5016, Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion].	0
NZ_CP027287.1\|WP_039362675.1\|1359388_1359721_+\|YnfA-family-protein	gnl\|CDD\|235016	PRK02237, PRK02237, YnfA family protein.	9.41681e-32
NZ_CP027287.1\|WP_065838939.1\|1373677_1375789_+\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0

>NZ_CP027287.1|WP_081299790.1|1363366_1364161_+|hypothetical-protein
MHAKPQILKEIGGFSHPESVFVYDGNIFVSNVGEKLEPLAKDGDGFISKLDYDGNTLQKTFIKDLNAPKGLFIEDGKLYVLDIDELKVFDVNSAKPVFSIKINGAIFLNHITKLNKTELLISDTATGLIHKVSLDKKTYETFASMDVARDGGPNGMTLLNGKLFIAGYDPNGKIAAIFGEFDGKNIKAVGELKGAFDGLVSDENANLYLSDWKDAKNGVIYKISKDKNEILQLRGLQGPADMFYDGKYLFVPEMVGEKLLKIKL
>NZ_CP027287.1|WP_023385617.1|1362388_1363243_+|helix-turn-helix-transcriptional-regulator
MILPNDLLHKYKFIGDDELIFLIYGSEITNLKYQAKFEKNAIIFVKNGKKIVYTSKKEYGINSGDILFLPSKSYTLSDIKAKNGYESLILFFSDELLIKLLKKYKVCFQKEIKTDNFICYINKDETLKNIFCSLELYSKNGVFDKNIINLKFEELFLYMLTSKNEIFNSYLSSLVKLNSIDFKAMFLDDIAFKTVFDMANAAKMDISSFSRKFKTLFKISPKEWIDDKRFDLALYLIKNSDKNINQICSECGFSSPAWFIARFKKKFNLTPNELKKSNNLYNLP
>NZ_CP027287.1|WP_039362678.1|1361176_1362322_+|iron-containing-alcohol-dehydrogenase
MVNFSYYNPTKIEFGKGKENSIGEYLNEYGAKNVLILFGSDRVKKDGLFDKATASLTKFGIKFSELGGIISNPVLSKVYEAINLARKNGVDSVLAIGGGSVLDTAKSVAAGAKYSGDVWDLFLGKAPIKDALMVFDIMTLAATGSEMNSFAVITNEDTKEKISITSSLVNPKVSVINPELMKSISKNYLVYSAADIIAHSIEGYLTATHHPEIISKLVEANISTIIKTTEILLADPENYDARAEFAWAATCALNGTTYVGVGGYSYPNHMIEHSISALYGVPHGAGLSVVMPAWMKWYKDKNKAQFSRFAKVIFGKNSADEGIEALKIWFEKIGTPTKLRDFGLDMSVSDITTAALHHAKAFGIADIYTKDVLEEILNLAY
>NZ_CP027287.1|WP_023385614.1|1360190_1361084_+|AraC-family-transcriptional-regulator
MDYRDEILELILKTKTNYGEIQTYIKPLSFYTAIKPTEFSNVMYEPSICVIIQGQKAVGFGNDLYSYDPYKYLLSTTYIPAKIRIEKASKDKPYISVVVKLKSEIIYDVIKEVGDFKIQNKKNIKNGLCFSELDNELLEAITKLVRLTNKPKNDAEFLSNLILKEIIYIILKQNGDLLKQYILEGNPENQISRAIMAIKNNFNENINMKKLSREIGISESLLYQNFKKITSLSPLQFQKKIRLEEAKNLLISTNLEASQIAFKVGYESPSQFSREYARMFGMPPKAHCSFLRDSINL
>NZ_CP027287.1|WP_023385612.1|1359748_1360048_-|hypothetical-protein
MKCPVCTDQNLMMSDRQGVEIDYCPSCRGVWLDRGELDKIIERSGTVEPKQNSQREYFDKQNHKDEYNGHRDSRYSDKYYQDGYKKKKKEGFLSELFDF
>NZ_CP027287.1|WP_039362675.1|1359388_1359721_+|YnfA-family-protein
MIQNITLFFIAAFFEILGCFAFWLYFRNDKTHWWLGLGAVSLLIFAYILTKIDVSHAGRIYAIYGGIYIISSLVWLALVEKESFNIWDILGSFLALLGAFVIFFGNSKID
>NZ_CP027287.1|WP_002850080.1|1358954_1359257_+|F0F1-ATP-synthase-subunit-C
MKKVLFLVVALASFAFGADGEQIKAFSVVAAGIGLGVAALGGAIGMGHTAAATILGTARNPGLGGKLLTTMFIALAMIEAQVIYALVIALIALYANPFLG
>NZ_CP027287.1|WP_065841333.1|1357023_1358844_+|invasion-protein-CiaB
MNNFAALNKLVKRQKNELNNLYKNMDNEIVSKALNLCSLDSSSVNKIAILRRIVDLNEVGIINELKNGGKSEGEIDAIKAKMYDFVSEFYINRHSSLINEVEEKGILEPFYLELIKSVHRIGVSLSKMQKIWQKSIIETTNREFETKFESIAKANEFITKNKLYQTNPDNSRCDRVYGAVIKNGEDYKLAPYAVSFKDEMKSVKDAFETSLVNLEKLSKTKDDKSYVIYLTKLKNAFLQTNNDLVIASWQDAERAWMDTKGKIQIGHPLEYYEDAYTHAVALEWDIRLVDDSHIDETKFKNSIKESFDEIYSKTGVKNQNMTNLVHSNIDKTQLYISVPMVYYAAEFNGLFSAQVVPNDEIVSRECGKKIFAFVNFVYESTKAKPFMKLASEIFDKDFLDFGREILYKKPEIWKKVYEISTIGHEFGHILFIDSDTESAMNKSGEFKFIEEYKATTGGLINFFLHEDYTYKMAVFHELIKRSVGLIAWQKVTETRAYYCEGLIHLSLLFRSGVLKFDGKKLQINFTQNGYESFKNEVMQNYINLATHYSNKLDAGEFLAKFAKFEGEIYLPQDRETLEFVKFYYQKYEKIANEIDDSGEWQKWQQA
>NZ_CP027287.1|WP_039362667.1|1355840_1356854_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MKKILFLVATIFMTLFLNAKENDMRNLKEIYLAGGCFWGTQAYFDKIPGVVKTDVGYANGKSDKTDYRSLHYSGHAETVHISFDENIVNLAEILAHYFRIIDPFSINKQGNDVGSQYRTGIYYNDKSLEDEISKFIKNEQTKYDKKIAVEVEPLKNYVLAEEYHQKYLDKNPGGYCHVDLSLADKPLYDESKFKSPSKDELKAKLSDLQYAVTQEKSTEKPYSSEYDKFDKKGIYVDIVSKKPLFSSSDKFDAGCGWPSFTKPITTDALGYNRDLSHGMDRVEVTSNLANSHLGHVFTDGPKDKGGLRYCINGASLKFIPLEDMEKEGYKDYIIYVK
>NZ_CP027287.1|WP_002850076.1|1355344_1355755_-|acyl-CoA-thioesterase
MKDMGEPRIKIVAMPSDTNPAGNIFGGWILSQIDLAGSIAARELAPTRVVTISMKEVIFKEPVFIGDIVSCYAKVVSVGNTSITTVVKVVVQRLNDGGFVECVPVTTAEVTYVSVDEQGNKKPIDSELKRLHGFVC
>NZ_CP027287.1|WP_065839422.1|1366628_1368005_+|sodium-dependent-transporter
MIEKFSKIGFVLAMAGSAVGLGNAWKFPTMVGNNGGSAFILLYVLLTLGIAVVVFLAELAIGKLGETDIVGSLYKLAPKHKKQWSLAGFFMITAVLIASFYMIVIGWILKYIFMSFSTLPADATAAGAAFGNLITNDFISVFICFTIVFLLVFYVVSKGIKSGIERLNIWMMPSLFGLLVLLLLYSIFQSGGFVSAVQFLFIPDFSKLLNPNIILQALGLAFFSMSMGVGTVATYAASLPDGTNLIKSTFSIVSINILIGIMMGLVVFSFIPIQDGQPASEGAGLIFVSLTSLFAQMGVAGNVLSVAFFISLLFAGITSAVSMIEPFTLYLINKFKISRKMSITFIGILVYILGICCILSYYGATSASFSLPKEIFATQKPVPFFDVLDFMTSNVLMPIGALTFSIFVGWILKRDGLYILFSGFISKTWFEIWYFALRFVAPIAIIAIGVYQLINKLN
>NZ_CP027287.1|WP_065840263.1|1368032_1369877_+|biotin-attachment-protein
MAKKFIDVMDTTFRDGFQSVFGARVLMDDFLPAVSAAKEAGINHFEFGGGARFQSLYFYLNEDAFLMMDKFRQAAGNDANLQTLSRGVNTVTLDTGSRELVDLHAKLFAKHNTNTIRNFDALNDVKNLQYSGERIVHHGLKHEVVVTMMDLPPNCEGAHDAAFYEKCLRDILNSDIKFHSVCFKDASGTSSPEKVYQTIKMARKLLGDSVHLRLHTHETAGVSVACYLAALEAGADGIDLAASPVSGGTSQPDILTMLHAVKGKNYDLGGLDVEKILKYEDVLHGCLKDYFMPPEATQVSPLIPFSPMPGGALTANTQMMRDNNILDKFPAVIKAMREVVEKGGYGTSVTPVSQFYFQQAFNNVIFGPWKKIAEGYGKMVLGYFGKTPVAPHQDIVELASKQLELEPTNESAIDIADKDETKSLAYTKAILEKEGIEQTEENIFIAAACKEKGVAYLKGDGKVMVRKISNMPKPVLNQTATKTKSEANKYSIVVNGSKYNVEVSDGFDNFEIKSVTPVTNKPAQTTEKKDKSKTEQSSEISSSNGSNEIRATMSAGVFKILVKVGDTVGKGQTVVILEAMKMEIPVESPSAGVVSEILITQGQSVDDGQILIKL
>NZ_CP027287.1|WP_105459600.1|1370034_1371609_+|phosphoenolpyruvate-carboxykinase-(ATP)
MKDVDKLGLKDIKEIYHNLSYDKLFEHEKANGEGYITNSGTFGVDTGIFTGRSPKDKYFVKQDPSQKYIAWGKVNKPIGKEIFDKLLHKAQQQLSGKNIYIQDAYCGSSLASRKSVRFVTEVAWQAHFVKNMFIRPSQNELAEFKPDFVVYNACKCVDDDYKEDGLNSEVFVVFNIEENIAVIGGTWYGGEMKKGIFSMMNYWLPLENKLSMHCSANVGKDGDTALFFGLSGTGKTTLSTDPNRALIGDDEHGWDDEGVFNFEGGCYAKCINLDPKSEPEIYAAIKKDALLENVCCDGCGCVDYGDASKTENTRVSYPIEHIENHEPSLKAGHPKNIIFLTADAFGVLPPVSKLTKEQAMYYFLSGYTAKVAGTERGITEPQATFSACFGEPFMPLHPTVYARLLGEKIDKHQVNVYLVNTGWSGGAYGVGKRMSIKATRACINAILDGSIKKCEFENFDKFNLSIPKELDGVETKLLNPINTWNDKTQYLAARDKLANMFVENFNRYEDVEEGVQFAKAGPTN
>NZ_CP027287.1|WP_065840262.1|1371892_1373281_+|argininosuccinate-lyase
MQKMWEGRFSESSSELLEAFNASIEFDKELYKQDIAGSIAHAKMLGKCGILTSEQSQKIISGLQQVKSEIDNSEFEFKIEDEDIHMAVEKRLSEIIGKELGGKLHTARSRNDQVALDFRLFVQEQSVVISNLILDLIAVLKDIATEHKNTLMPGFTHLQHAQPISLAYHLLAYAFMFKRDYERLICSYQRNDLSPLGSCALAGTPHHINRKMVAEELGFKDITQNAMDSVSDRDFALELLFNISLIFTHTSRLCEELILWSSSEFRYITISDKFSTGSSIMPQKKNPDVAELIRGKTGRVYGNLISLLTVMKALPLAYNKDMQEDKECVFDSVKTAINSLIILKEMLKTTTFNKDFMLKACKNGHLSATDLADYLVRNLDIPFREAHFITGKCVSLAEKLGKDISELSLDELKSIHSDIKSDALEVLKLENSKEARQSLGGTSNKSVDTQLNELNLFLNLKI
>NZ_CP027287.1|WP_023385626.1|1373447_1373681_+|ferrous-iron-transport-protein-A
MDLSKLEINQKAILTGISGLQNTKRRLRSFGLDIGSQIQIKQKSITNSNIEILSKHGLIALRKNEAKMLSCELLAEK
>NZ_CP027287.1|WP_065838939.1|1373677_1375789_+|ferrous-iron-transport-protein-B
MSKQFVIALVGQPNVGKSQFLSSISGANPKIGNFAGVTVEKYEATLVKGDIVLNFIDLPGLYSMDDFSKDESVAKDFLMKSKYDMILNIVDSTNLERNLFLTSELMALGKKMVVALNMDDEAKSEGIEIDDKHLSSILNIPSIKISSVKKTNLNSLLDTIIDILSKPYSPNKLKFSDQIEEELIYLAQKIDEVGFKKDEICSRQAAILFLLEDKKFYTLSHEDPKILLLIPEIKKVFDDIKQKTQNSSIEDVLIDEYHSFAKGAALETQNIKAGKNTDITKKIDSILIHRFFGLPIFLFFMWLLFQATFTLGEVPMKYIEMVFAWFGNSIAANLNDDMLKSIIVDGIIAGVGTVILFLPNIIILFLGIALLETTGYMARVAFLLDGFFHKFGLHGKSFIPLVTGFGCSIPAYMAARTLKSQKDRLLTMFIIGFMSCGARLPVYVLFAGAFFKPENAGNVLFFIYISGALLGLMAAKVLRIFVFKGNDEPFVMEMPKYRLPSVKLIWLTIYSKSMMYLKKAGTFILAASILVWFVSTFPQNPNIEEKYQQQIQAASNDELKLELTHQKDQELMENTYLGMFGKAIEPVFAPLGFNWKMSVATVSGLAAKEVIVSTLGVLYSLGGEVSENNTTLQQTLSKSIPFASAMAFIVFVMVYLPCLAATAVFSKEAESKKYTFYLVTFTFCTAWMLAFITYKVITFLNIA
>NZ_CP027287.1|WP_158676892.1|1375911_1376067_-|hypothetical-protein
MTILALHSGRFFGNIGEFVFCVVSFFGALIALSGIIMTYFRLKPKFHHKIK
>NZ_CP027287.1|WP_152819273.1|1376265_1376484_-|hypothetical-protein
MKSKKEIIFYKFHAVFGVIFGLIFLFICLSGLYWSYEWINSLTNRAFGVPSSGAKMAHKKETNIIENSFFKR
>NZ_CP027287.1|WP_081302972.1|1376500_1376749_-|PepSY-domain-containing-protein
MQTVKEKENLTLFVSSEGEILGQDYGTKFNRFVRQLHRWLLFSEFDLQKLGKNIVALTTIGFMILAISGFYIYLPRLKYSFF
>NZ_CP027287.1|WP_141069927.1|1376863_1377064_-|TonB-dependent-receptor
MILKHIVDLGTNYKFKNGITVGAVVNNLLDKDFVDYVAYNNGKSYTNNYQRMIPGRNFWLTVRADF

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Crispr_ID: NZ_CP027287_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027287_6

1845341-1845429

Orphan

Consensus_repeat	Method
TTACTAGCGCCGCATTTTTCAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP027287_6

>merge|NZ_CP027287|6|1845341-1845429|CRISPRCasFinder
TTACTAGCGCCGCATTTTTCAGCCTTATTTGTTTCTTTAGGCTTTTCTACTTTTGTGTCACCGCATTTGCTAGCGCCGCATTTTTCAGC

>NZ_CP027287|6|6|1845341-1845429|CRISPRCasFinder
TTACTAGCGCCGCATTTTTCAGC	CTTATTTGTTTCTTTAGGCTTTTCTACTTTTGTGTCACCGCAT
TTGCTAGCGCCGCATTTTTCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027287.1\|WP_065838430.1\|1844313_1844835_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379295
NZ_CP027287.1\|WP_065841985.1\|1841994_1842615_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|234847
NZ_CP027287.1\|WP_023386313.1\|1848466_1849420_-\|KpsF/GutQ-family-sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|129488
NZ_CP027287.1\|WP_081299783.1\|1838963_1839980_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NZ_CP027287.1\|WP_065838432.1\|1852212_1853445_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP027287.1\|WP_039363098.1\|1854321_1854861_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|376443
NZ_CP027287.1\|WP_105459591.1\|1846232_1846748_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|378988
NZ_CP027287.1\|WP_023386311.1\|1847702_1848467_-\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NZ_CP027287.1\|WP_105459604.1\|1837352_1838150_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|223672
NZ_CP027287.1\|WP_039363435.1\|1849443_1851162_-\|ribonuclease-J	unknown	unknown	gnl\|CDD\|223668
NZ_CP027287.1\|WP_065839986.1\|1841537_1841984_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NZ_CP027287.1\|WP_065841372.1\|1842648_1844298_-\|GMC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|225186
NZ_CP027287.1\|WP_023386317.1\|1851373_1852180_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP027287.1\|WP_023386319.1\|1853566_1854325_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP027287.1\|WP_065840639.1\|1846723_1847701_-\|HrgA-protein	unknown	unknown	gnl\|CDD\|225506
NZ_CP027287.1\|WP_023386303.1\|1844824_1845259_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP027287.1\|WP_065838482.1\|1845611_1846199_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380324
NZ_CP027287.1\|WP_158004529.1\|1838803_1838956_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027287.1\|WP_065841984.1\|1839976_1841284_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225743
NZ_CP027287.1\|WP_023386287.1\|1838208_1838694_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380361

Protein	Function_ID	Function_description	E-value
NZ_CP027287.1\|WP_065838430.1\|1844313_1844835_-\|hypothetical-protein	gnl\|CDD\|379295	pfam13618, Gluconate_2-dh3, Gluconate 2-dehydrogenase subunit 3. This family corresponds to subunit 3 of the Gluconate 2-dehydrogenase enzyme that catalyzes the conversion of gluconate to 2-dehydro-D-gluconate EC:1.1.99.3.	0.00428939
NZ_CP027287.1\|WP_065841985.1\|1841994_1842615_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|234847	PRK00847, thyX, FAD-dependent thymidylate synthase; Reviewed.	4.62746e-78
NZ_CP027287.1\|WP_023386313.1\|1848466_1849420_-\|KpsF/GutQ-family-sugar-phosphate-isomerase	gnl\|CDD\|129488	TIGR00393, Probable_arabinose_5-phosphate_isomerase, KpsF/GutQ family protein. This model describes a number of closely related proteins with the phosphosugar-binding domain SIS (Sugar ISomerase) followed by two copies of the CBS (named after Cystathionine Beta Synthase) domain. One is GutQ, a protein of the glucitol operon. Another is KpsF, a virulence factor involved in capsular polysialic acid biosynthesis in some pathogenic strains of E. coli. [Energy metabolism, Sugars].	1.95414e-94
NZ_CP027287.1\|WP_081299783.1\|1838963_1839980_-\|SDR-family-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.55219e-72
NZ_CP027287.1\|WP_023386319.1\|1853566_1854325_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	1.18505e-171
NZ_CP027287.1\|WP_039363098.1\|1854321_1854861_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|376443	pfam01048, PNP_UDP_1, Phosphorylase superfamily. Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase).	1.16622e-05
NZ_CP027287.1\|WP_105459591.1\|1846232_1846748_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|378988	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase. Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	9.69617e-19
NZ_CP027287.1\|WP_023386311.1\|1847702_1848467_-\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	9.22264e-70
NZ_CP027287.1\|WP_105459604.1\|1837352_1838150_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|223672	COG0599, COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown].	1.85487e-12
NZ_CP027287.1\|WP_039363435.1\|1849443_1851162_-\|ribonuclease-J	gnl\|CDD\|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NZ_CP027287.1\|WP_065839986.1\|1841537_1841984_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	7.85162e-46
NZ_CP027287.1\|WP_065841372.1\|1842648_1844298_-\|GMC-family-oxidoreductase	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	5.63803e-55
NZ_CP027287.1\|WP_023386317.1\|1851373_1852180_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	1.39842e-84
NZ_CP027287.1\|WP_065840639.1\|1846723_1847701_-\|HrgA-protein	gnl\|CDD\|225506	COG2958, COG2958, Uncharacterized protein conserved in bacteria [Function unknown].	3.66781e-79
NZ_CP027287.1\|WP_023386303.1\|1844824_1845259_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	4.56457e-19
NZ_CP027287.1\|WP_065838482.1\|1845611_1846199_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|380324	cd02149, NfsB-like, nitroreductase similar to Escherichia coli NfsB. NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.	7.74187e-31
NZ_CP027287.1\|WP_065838432.1\|1852212_1853445_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.42693e-73
NZ_CP027287.1\|WP_065841984.1\|1839976_1841284_-\|MFS-transporter	gnl\|CDD\|225743	COG3202, COG3202, ATP/ADP translocase [Energy production and conversion].	7.51767e-26
NZ_CP027287.1\|WP_023386287.1\|1838208_1838694_-\|cupin-domain-containing-protein	gnl\|CDD\|380361	cd02233, cupin_HNL-like, Granulicella tundricola hydroxynitrile lyase (GtHNL) and related proteins, cupin domain. This family includes archaeal, eukaryotic, and bacterial proteins homologous to hydroxynitrile lyase from Granulicella tundricola (GtHNL), a novel class of HNLs that does not show any sequence or structural similarity to any other HNL and does not contain conserved motifs typical of HNLs. HNLs comprise a diverse group of enzymes that vary in terms of their substrate specificity, enantioselectivity and the need for a co-factor. In plants, they catalyze the reversible cleavage of cyanohydrins, yielding HCN and aldehydes or ketones. Also included in this family is TM1010 from Thermotoga maritima, a protein of unknown function. Some but not all members of this family have N- or C-terminal carboxymuconolactone decarboxylase domains in addition to the cupin domain. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.33547e-46

>NZ_CP027287.1|WP_023386303.1|1844824_1845259_-|DoxX-family-protein
MKKFCNVFNMLGSKFQHLSLLIMRLVLAYGFYETAVPKWQNIEPTAQWFSSMGFPIPVLIVYLVAIFESLAVLLFVLGLFTRIISIPLIAIVLVAIFAVHFENGYSLANNGFEVPLYYLVMLLGLFSFGAGNISLDAVMNRHEK
>NZ_CP027287.1|WP_065838430.1|1844313_1844835_-|hypothetical-protein
MRNRRSFVKVAYGIMVFSGAPINLFAQNESILDDKTLSKDEIYSILNSVSKHLFPIATQLNIDILSYLKIIISHSKVSLSAKNFIINGAVWLNDTSIKQYESDYLSLSNKKQNDLLDIVAKDEEWGESWIYDMLVFCSEAVFSDPIYGANIDENGWKWISHETGLPQPKTPFL
>NZ_CP027287.1|WP_065841372.1|1842648_1844298_-|GMC-family-oxidoreductase
MTYDVCIIGSGAGASPVAYELSKAGFNVVVLEKGKFYKEEDFSKDELAISRRKMFVPNLKDEYHVVIEKEPNGEISRYDGTWSFWNGSLVGGSSNLMSGFFHRLKPNDFKLKSVYGEIEGANVADWPISYDELEPYYTKVEKVVGVSGKVVKHKFSEPRSTAEFPYEKLEENAAAKWFDKAAIELGLTPLPTPRAILSKNDLGRNACYYSHFCGAYPCASGAKGSGRVLLQQCPAKVIPEAFVYKLVSDKFGVKEALYYDKFKKSHSIKAKIFVVAAGVVETSRLLLNSKNRHFPNGLANNSANVGKNLIFSAGGVGSGTFYLKDLSKKDANDLMSRGLFFNRHIQEWYEFKKDGKRYKGGTIDFLFEHPNVIPNVTAQFYESGNLIFGDKLMTKIKDNVYASRKLTFEVFNDWLPTNTTFVSVSDTHRDKYEVPVGVISLDAHKQDLEVGEFLSQKAVEILKQMGAKDVSYSVSSSPPPNLVAGGARFGDDPKTSVLDKNCKAHELDNLYVSDASFMPTGGSVPYTWSIYANSFRVADIIKKRLSNLV
>NZ_CP027287.1|WP_065841985.1|1841994_1842615_-|FAD-dependent-thymidylate-synthase
MEVKLLNFTPLWVCSNAIRTCWQSFERGDNGGEKDIELIDRVGNKFKHASTLEHLYYNFYIKGISRALLQELARHRIASLSVKSTRYTLKELKNESEFKAGDFENASRYLVLTGNEFVDNASINALENLRQILNQNTSLDIAKYCLPESYKTELSWSINARSLQNFLSLRSSKAALWEIRDLANLIYQNLPSDHKFIYENCLVKPE
>NZ_CP027287.1|WP_065839986.1|1841537_1841984_-|MerR-family-transcriptional-regulator
MAKTIIDVEKQTGISSRTIRFWLKKGLFPFVERDKNGVNYFSDRDVEWVIWVDCLRKTGMSIEKIKHYIALAAKGKSSAQLRLKMIEEQKEAVKAEIKKLEEIDKKLDYKIGYYKDMLANNEDTINPVSSTYEGVDYFRSKAKAIGLR
>NZ_CP027287.1|WP_065841984.1|1839976_1841284_-|MFS-transporter
MSLNQILSLKKGEGKFLLIAVLFIFSLFASYSLLRPIREALGISGGTGELKWLFLGTFIATIVGSILAMILSGMIKRKLYTDFIYGFFALNLIGFFIILHQISQGSEAYLIVARSFYIWVSVFNIFVISTAWSLLADVFSKERSARLFGIISAGASLGGIFGAFFVSVLSKFIDVPSFIFISIICLGVSIVLKNLLIKEALGLEELNLQSGFVSIKDRFDKPIGSKNPFVGFLLIIKSRYLLALLGFILLLTSVSTFLYMEQARVISGMFESREARAAAFANIDFIVQLSSFVIQIFITSKIVQFFGIKWLLGTLGFVVALGFVLLVFYPAFGVLVLVMSIRRVGEYALVKPGREMLFVPLDSESKYKVKNFLDTVVYRAGDSMSAALEGTIAKISITAVLFVGALISFIWGSLGVYLGKRYEKEEFKFKNEEIK
>NZ_CP027287.1|WP_081299783.1|1838963_1839980_-|SDR-family-oxidoreductase
MKDSRRKFIKNTMVLGAASLAGATILNAKTDDKNRENKMNTQIWYITAASGGLGLALAKYLLSKGDKVAGTSRNLKNIIDKLGKESENFLPLELKFGEKMSENIEANIAAIKSKFSRLDNVVNNAGYGLLGFVEETSEKDLRAQFEVNVFAPFLVAKHALKLMRPQAISEGGNAQNVKARIFNLSSIGGFRVTNNSTPYCMSKFALSAFSEGLLLDLKDFGIRSVNIMPAGFRTEFLGTSMELSRDKIGDYDAKREAFEAHAKNYSGKQAGNPAKFAEILYNVSRMQEPPFSLFLGAAAFSSARNKISWLEEDMKNTEHYARSAADFENSAGSAFSTR
>NZ_CP027287.1|WP_158004529.1|1838803_1838956_-|hypothetical-protein
MNKNLAMQISKTQSSSTNITLKINALCEGAFNAPFELSNTFTSFINNTFS
>NZ_CP027287.1|WP_023386287.1|1838208_1838694_-|cupin-domain-containing-protein
MFKKFIKCCALFVGASASAASTQSVVRSGELGGFKGDSRYFTGEVSVSMLFKSDTYRPFSGALVEFSPKARTAWHTHPAGQTLIVTKGQIYTATKNGVLQIANTGDVILCPPDVKHFHGAGLETKAAHIALTAEKDGKNVTWMEHVSDEEYEKLVKQDKKD
>NZ_CP027287.1|WP_105459604.1|1837352_1838150_-|carboxymuconolactone-decarboxylase-family-protein
MSAKADAKEQNTEKKVENLSDNAKKNYDKFFGDTNPLSKTDPEFITNHLNFAFGDLFLHSKLDDKTRIMLWLGCLIASGGLREYKRAVNAALKNGVAPNNIKEILYQSVPYVGFAKVDEFIYVCNEVFRDNGVELPLKNASTTTASDREEKGLAVQRAFFGDTIGRSNAAAPNDEKHIRKFLSANCFGDYYTRDGLEPKFRELLTFVFVLSIGGADAQVKAHVVGNLNLGNTRAVLIDTVTSLIPYIGYPRSLNALSAIDEVSSV
>NZ_CP027287.1|WP_065838482.1|1845611_1846199_-|NAD(P)H-dependent-oxidoreductase
MQNRFSCRKFKNEKIENAKIKEILDFARLTPSSCGLEPWKFVVISKSDELDELGKICNNQDQVKTCSHAVVILARNDLKSSCEFLQNQVKRKQTITEKYNKAMEYFANRFDHQTNDELTHYASLQCYLLCANLINIAYDMDIKSCVIGGFDKISLTNFINLTNNFTPVLVVALGLSDETAPVKMRLSLDDILIWR
>NZ_CP027287.1|WP_105459591.1|1846232_1846748_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MRRSDRELDQESALKIIDESQYATLSCVDEKGEVFSIPISIARDGMSVFIHGAKTGSKAKLYKDGKNVELVAVSQNKVPTPSYEFCESIKDSANELGGKVFTTEYLSAIAKTKAYEVTDESQKVKALELLCRKYTPDYMDYFKTAVYGSLSRTSIYELKIVSLSAKAKIIK
>NZ_CP027287.1|WP_065840639.1|1846723_1847701_-|HrgA-protein
MIRTVIGVAKEVLERKKEALNPNRMYHIANEMGLTEELNLSGKTPWASFAARIYVDIKENSDSIFEVVATKPILIKLKNQDINLKAQIEKNSEIKEPKTSYSERDLHQLLTRFAFANDNFKAYTKTIYHESSIKTKKGIDKWLYPDIVGVSFEYRDYQKELNKFICKFNSLPIKIYAFEMKKHLSVSSFREYYFQAVSNSSWANEGYLVALDIDESDEELMDLIKRLSFSFGIGVISLSSQNVDESVILARAKFKESLDYSVMNELSIKNPDFKKFLESIEEFNIEKDYRSKSEFDEVLDNDKLESYLKDKKISKETLCDEVTVN
>NZ_CP027287.1|WP_023386311.1|1847702_1848467_-|rRNA-pseudouridine-synthase
MRINKFISHNTNYSRREADELVKNGKVSVNNKVIDNLATDVKEDDKIKINGRFIKLKKEFSVIVYNKQKGELVTKKDDRGRKTIYDNLPRGLSKFISIGRLDFASEGLLLLTDAPAIAEALMGSDIEREYYLKIKGEITPNVITAMQEGFFAKDATKGAHARTKQISMDFKPFLAYKIISFSGGYTRLKVIINEGQNRELRRFFGYFDLEVMDLKRVSFGRVSLDQLGEGKWRYFTNKEYDDLRDFLKQNGVRY
>NZ_CP027287.1|WP_023386313.1|1848466_1849420_-|KpsF/GutQ-family-sugar-phosphate-isomerase
MDILSIAKEVLNLEADELKRQAKLLDFKFEQAINLALSCKGKLIISGVGKSGLIGAKIAATLASTGTPSFFLHPTEALHGDLGMISQNDMILAISFSGESSELIAILPHIKKRGIKIIGMAKSSSSLEMLSDAFISLDIVREACPLGAAPTVSTTLTLALGDALAVCLMQLKEFKKEDFAMLHPGGSLGKRLYLKVKDVMRKDELPIVSDDVSLKFAINSMTHGKLGTVLLTNTDGLLVAVLSDGDLRRALGNDNFNINDQAIKFATKNPKVLEDENMLAYDALKLIEEYKIQILIITKDKKPIGALHIHDLTSLGL
>NZ_CP027287.1|WP_039363435.1|1849443_1851162_-|ribonuclease-J
MEANRASHELRLNPLKYLNSSEHKIKITPLGGLGEIGGNMTVFETENDAIIVDIGMSFPSESMHGVDILIPDFDYIRKIKQKVRGIIITHAHEDHIGAVPYFFKEFQFPIYATPLPLGMISNKFEEHGLKAHRSYFRPMEKRKPYVIGDFEIELIHITHSIIDASALVITTKAGTILHTGDFKIDHTPIDGYPTDLNRLAYYGERGVLCMLSDSTNSYKEGITKSESSVGKTFDSIFATSTGRVIMSTFSSNIHRVYQAIERGVKHGRKVCVIGRSMERNLWTAIELGYVNLDKKIFIDANEVSKYPDNEVLIVTTGSQGETMSALYRMATDEHKYIKIKPTDQIIISSKAIPGNETSVSTVLNYLLKSGASVAHQDFSEIHVSGHAAQEEQKLMLRLVKPKFFLPVHGEYNHIVRHKETAVACGVDERNTYLMSDGDQIEVCQKYIKRVKTVKTGKVFIDNQINKQISDDVVIDRQKLAEAGVVTIISQIDKNAKTLIQNRVISYGLVSERQSKNLSKEMEEILLQFLSNVKDELLHDQRALENQIRQVIRKHIFRKIKKYPTIVPVVYLM
>NZ_CP027287.1|WP_023386317.1|1851373_1852180_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MIKAKKKFGQNFLQDENIKNQIIKAIPNGVKRIVEIGPGLGDLTQKLVKLDSMIDCFEIDSELYAILLDKFRSELDSGKLNIINSDALNAWDKLSASEYFLVANLPYYVATNMILKAIDDNNCKGLVVMIQREVAIKFSSEAGDKEFSSLAILTELKGRCELLFDVPNSAFNPPPKVVSSVIRIIKDRDLSLNLKYDNFKDFLRASFSAPRKTLLKNLSNLVQKSRLEMFFNAENLSHTIRPHELSVALYLKLFKEAENERRKQNPCG
>NZ_CP027287.1|WP_065838432.1|1852212_1853445_-|MFS-transporter
MPNKFSNPLKALKYRNFRLYWFGMMISQTGTWMQNIAQPWLALEVTNNATLVGIVAAVQFLPLLIFSLFSGALLDKIDKKFILKITQTGMCLTSLAFGLSIIFGFVNYPLILVLAFLTGLFNCLDAPCRQSFLYELIDDKKDVANAVALNSMSVNAARIMGPVFAGIVMAKFGLAACFFLNSVSFIAIFISLFFIKHNPSKTNKRKENILKSILSGFHYIKKREILISPLIVVLIVGTFLPNYNVTISALSKYSLSGAEDTFAYLMAFLGIGSFFGALWVAFTSKNISYKTVKIMPFIAATFLIAIGLSRNFTTAGVFLAMTGFSFMICVSTINSLLQLNSREDFRGRVMSVYVLFFLGSTPIGAVISGALANKFGAGMALVICGVCVYILLIIWWIIKSYYLNLKIKFN
>NZ_CP027287.1|WP_023386319.1|1853566_1854325_+|imidazole-glycerol-phosphate-synthase-subunit-HisF
MDKFAKRIIPCLDVNNGRVVKGINFVGLRDAGDPVEVAKRYNDEGADELCFLDITASSDGRDTIVHVVEEVAKQLFIPLTVGGGIRKIDDISRLLNVGCDKVSLNSAAIHNPNLISEAANKFGSQCVVVAIDVKKAGESYHVFINGGRVDTKIDAYEWAKKVYELGAGEILLTSMDSDGTKNGYDLEVTSQISNLVGIPVIASGGAGTMEHILEAFRAGADAALAASIFHYKEIEISELKKYLLANGIGVRI
>NZ_CP027287.1|WP_039363098.1|1854321_1854861_+|purine-nucleoside-phosphorylase
MIVCAGLNESFEFAIPIGVGITSSAINLTKILTVNKADEIIFVGTCGLYKDGNLLDIYESKTAVNLEISSLLGLSYSPLLSSPIVQNLKNVSCETLITNSSNFITINRDIAHKFSELGLFMENMELYSVLETAKQFKIPARGILCATNFCEPNAHNEFIKNHNKAKINLEKYLKERDII

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP027287_2	2.33\|714312\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714312-714346	35	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	28531-28565	2	0.943
NZ_CP027287_2	2.33\|714312\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714312-714346	35	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	42908-42942	2	0.943
NZ_CP027287_2	2.37\|714574\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714574-714608	35	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	28531-28565	2	0.943
NZ_CP027287_2	2.37\|714574\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714574-714608	35	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	42908-42942	2	0.943
NZ_CP027287_2	2.53\|715629\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	715629-715663	35	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	28531-28565	2	0.943
NZ_CP027287_2	2.53\|715629\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	715629-715663	35	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	42908-42942	2	0.943
NZ_CP027287_3	3.35\|726440\|35\|NZ_CP027287\|CRISPRCasFinder,CRT	726440-726474	35	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	40316-40350	2	0.943
NZ_CP027287_3	3.35\|726440\|35\|NZ_CP027287\|CRISPRCasFinder,CRT	726440-726474	35	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	31124-31158	2	0.943
NZ_CP027287_3	3.5\|726439\|36\|NZ_CP027287\|PILER-CR	726439-726474	36	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	40315-40350	3	0.917
NZ_CP027287_3	3.5\|726439\|36\|NZ_CP027287\|PILER-CR	726439-726474	36	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	31124-31159	3	0.917
NZ_CP027287_2	2.32\|714246\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714246-714281	36	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	78163-78198	4	0.889
NZ_CP027287_2	2.32\|714246\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714246-714281	36	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	10302-10337	4	0.889
NZ_CP027287_2	2.36\|714508\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714508-714543	36	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	78163-78198	4	0.889
NZ_CP027287_2	2.36\|714508\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714508-714543	36	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	10302-10337	4	0.889
NZ_CP027287_2	2.52\|715563\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	715563-715598	36	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	78163-78198	4	0.889
NZ_CP027287_2	2.52\|715563\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	715563-715598	36	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	10302-10337	4	0.889
NZ_CP027287_5	5.1\|1366313\|28\|NZ_CP027287\|CRISPRCasFinder	1366313-1366340	28	LC168164	Tenacibaculum phage pT24 DNA, complete genome	106151-106178	4	0.857
NZ_CP027287_5	5.1\|1366313\|28\|NZ_CP027287\|CRISPRCasFinder	1366313-1366340	28	NC_006870	Bacillus mycoides pDx14.2 plasmid	8937-8964	6	0.786
NZ_CP027287_5	5.1\|1366313\|28\|NZ_CP027287\|CRISPRCasFinder	1366313-1366340	28	NZ_AP018688	Vibrio rumoiensis strain FERM P-14531 plasmid 2, complete sequence	67096-67123	6	0.786
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	76846-76880	7	0.8
NZ_CP027287_3	3.52\|727557\|36\|NZ_CP027287\|CRISPRCasFinder,CRT	727557-727592	36	NZ_CP015884	Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence	78816-78851	7	0.806
NZ_CP027287_5	5.1\|1366313\|28\|NZ_CP027287\|CRISPRCasFinder	1366313-1366340	28	NZ_CP015352	Bacillus thuringiensis strain MYBT18246 plasmid p142098, complete sequence	63615-63642	7	0.75
NZ_CP027287_5	5.1\|1366313\|28\|NZ_CP027287\|CRISPRCasFinder	1366313-1366340	28	NZ_CP015356	Bacillus thuringiensis strain MYBT18246 plasmid p101287, complete sequence	59093-59120	7	0.75
NZ_CP027287_5	5.1\|1366313\|28\|NZ_CP027287\|CRISPRCasFinder	1366313-1366340	28	NZ_CP017256	Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence	65407-65434	7	0.75
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	NC_019765	Stanieria cyanosphaera PCC 7437 plasmid pSTA7437.01, complete sequence	278192-278226	8	0.771
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	MG592541	Vibrio phage 1.174.O._10N.261.55.A8, partial genome	18316-18350	8	0.771
NZ_CP027287_3	3.22\|727556\|37\|NZ_CP027287\|PILER-CR	727556-727592	37	NZ_CP015884	Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence	78815-78851	8	0.784
NZ_CP027287_3	3.39\|726703\|35\|NZ_CP027287\|CRISPRCasFinder,CRT	726703-726737	35	NZ_CP037749	Campylobacter helveticus strain 2013D-9613 plasmid unnamed1	350-384	8	0.771
NZ_CP027287_3	3.49\|727358\|35\|NZ_CP027287\|CRISPRCasFinder,CRT	727358-727392	35	NC_013940	Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence	207765-207799	8	0.771
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	401342-401376	9	0.743
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	NZ_CP031072	Bacillus mycoides strain BPN401 plasmid pl395, complete sequence	33963-33997	9	0.743
NZ_CP027287_3	3.19\|727357\|36\|NZ_CP027287\|PILER-CR	727357-727392	36	NC_013940	Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence	207764-207799	9	0.75
NZ_CP027287_3	3.42\|726901\|35\|NZ_CP027287\|CRISPRCasFinder,CRT	726901-726935	35	NZ_LR214942	Mycoplasma orale strain NCTC10112 plasmid 3	2164-2198	9	0.743
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	AP013388	Uncultured Mediterranean phage uvMED DNA, complete genome, group G15, isolate: uvMED-CGR-C54-MedDCM-OCT-S36-C37	29896-29930	10	0.714
NZ_CP027287_3	3.12\|726900\|36\|NZ_CP027287\|PILER-CR	726900-726935	36	NZ_LR214942	Mycoplasma orale strain NCTC10112 plasmid 3	2163-2198	10	0.722
NZ_CP027287_2	2.6\|712535\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712535-712569	35	NC_020292	Clostridium saccharoperbutylacetonicum N1-4(HMT) plasmid Csp_135p, complete sequence	126692-126726	11	0.686
NZ_CP027287_2	2.17\|713259\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	713259-713294	36	MN694470	Marine virus AFVG_250M476, complete genome	29674-29709	11	0.694
NZ_CP027287_2	2.17\|713259\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	713259-713294	36	MN693658	Marine virus AFVG_250M475, complete genome	29963-29998	11	0.694
NZ_CP027287_2	2.18\|713325\|36\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	713325-713360	36	AP013402	Uncultured Mediterranean phage uvMED DNA, complete genome, group G15, isolate: uvMED-CGR-U-MedDCM-OCT-S38-C27	35840-35875	11	0.694
NZ_CP027287_2	2.40\|714771\|37\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	714771-714807	37	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	33684-33720	11	0.703
NZ_CP027287_1	1.18\|706689\|35\|NZ_CP027287\|CRISPRCasFinder	706689-706723	35	NC_049978	IAS virus, complete genome	73150-73184	12	0.657
NZ_CP027287_2	2.3\|712341\|35\|NZ_CP027287\|PILER-CR,CRISPRCasFinder,CRT	712341-712375	35	NC_049978	IAS virus, complete genome	73150-73184	12	0.657

1. spacer 2.33|714312|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 2, identity: 0.943

tccggatttagcaaggaagctttagctctagcttc	CRISPR spacer
tttggatttagcaaggaagctttagctctagcttc	Protospacer
*..********************************

2. spacer 2.33|714312|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 2, identity: 0.943

tccggatttagcaaggaagctttagctctagcttc	CRISPR spacer
tttggatttagcaaggaagctttagctctagcttc	Protospacer
*..********************************

3. spacer 2.37|714574|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 2, identity: 0.943

tccggatttagcaaggaagctttagctctagcttc	CRISPR spacer
tttggatttagcaaggaagctttagctctagcttc	Protospacer
*..********************************

4. spacer 2.37|714574|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 2, identity: 0.943

tccggatttagcaaggaagctttagctctagcttc	CRISPR spacer
tttggatttagcaaggaagctttagctctagcttc	Protospacer
*..********************************

5. spacer 2.53|715629|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 2, identity: 0.943

tccggatttagcaaggaagctttagctctagcttc	CRISPR spacer
tttggatttagcaaggaagctttagctctagcttc	Protospacer
*..********************************

6. spacer 2.53|715629|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 2, identity: 0.943

tccggatttagcaaggaagctttagctctagcttc	CRISPR spacer
tttggatttagcaaggaagctttagctctagcttc	Protospacer
*..********************************

7. spacer 3.35|726440|35|NZ_CP027287|CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 2, identity: 0.943

tctgttacaaagcctacttgctttaagccctggct	CRISPR spacer
tctgttgcaaatcctacttgctttaagccctggct	Protospacer
******.**** ***********************

8. spacer 3.35|726440|35|NZ_CP027287|CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 2, identity: 0.943

tctgttacaaagcctacttgctttaagccctggct	CRISPR spacer
tctgttgcaaatcctacttgctttaagccctggct	Protospacer
******.**** ***********************

9. spacer 3.5|726439|36|NZ_CP027287|PILER-CR matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 3, identity: 0.917

ctctgttacaaagcctacttgctttaagccctggct	CRISPR spacer
atctgttgcaaatcctacttgctttaagccctggct	Protospacer
 ******.**** ***********************

10. spacer 3.5|726439|36|NZ_CP027287|PILER-CR matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 3, identity: 0.917

ctctgttacaaagcctacttgctttaagccctggct	CRISPR spacer
atctgttgcaaatcctacttgctttaagccctggct	Protospacer
 ******.**** ***********************

11. spacer 2.32|714246|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 4, identity: 0.889

tgttctgtttttgcggtgcggttaaagtccattata	CRISPR spacer
tgctctgtttttgcgctgcggttaaagtccattaac	Protospacer
**.************ ******************

12. spacer 2.32|714246|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 4, identity: 0.889

tgttctgtttttgcggtgcggttaaagtccattata	CRISPR spacer
tgctctgtttttgcgctgcggttaaagtccattaac	Protospacer
**.************ ******************

13. spacer 2.36|714508|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 4, identity: 0.889

tgttctgtttttgcggtgcggttaaagtccattata	CRISPR spacer
tgctctgtttttgcgctgcggttaaagtccattaac	Protospacer
**.************ ******************

14. spacer 2.36|714508|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 4, identity: 0.889

tgttctgtttttgcggtgcggttaaagtccattata	CRISPR spacer
tgctctgtttttgcgctgcggttaaagtccattaac	Protospacer
**.************ ******************

15. spacer 2.52|715563|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 4, identity: 0.889

tgttctgtttttgcggtgcggttaaagtccattata	CRISPR spacer
tgctctgtttttgcgctgcggttaaagtccattaac	Protospacer
**.************ ******************

16. spacer 2.52|715563|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 4, identity: 0.889

tgttctgtttttgcggtgcggttaaagtccattata	CRISPR spacer
tgctctgtttttgcgctgcggttaaagtccattaac	Protospacer
**.************ ******************

17. spacer 5.1|1366313|28|NZ_CP027287|CRISPRCasFinder matches to LC168164 (Tenacibaculum phage pT24 DNA, complete genome) position: , mismatch: 4, identity: 0.857

ctcaaataattcaaactctataaacaat	CRISPR spacer
ttcaaataattcaaactttataaatgat	Protospacer
.****************.******..**

18. spacer 5.1|1366313|28|NZ_CP027287|CRISPRCasFinder matches to NC_006870 (Bacillus mycoides pDx14.2 plasmid) position: , mismatch: 6, identity: 0.786

ctcaaataattcaaactctataaacaat	CRISPR spacer
tcgtaataactcaaactctataaaaaat	Protospacer
..  *****.************** ***

19. spacer 5.1|1366313|28|NZ_CP027287|CRISPRCasFinder matches to NZ_AP018688 (Vibrio rumoiensis strain FERM P-14531 plasmid 2, complete sequence) position: , mismatch: 6, identity: 0.786

ctcaaataattcaaactctataaacaat	CRISPR spacer
ttgagttaattccaactctataaacaaa	Protospacer
.* *. ****** **************

20. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 7, identity: 0.8

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
tctatctttttaaattacctttttttaccaattgt	Protospacer
****** ********* ********* .. *** *

21. spacer 3.52|727557|36|NZ_CP027287|CRISPRCasFinder,CRT matches to NZ_CP015884 (Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence) position: , mismatch: 7, identity: 0.806

aagatttctattaataatcaaattttagaggaacaa	CRISPR spacer
attagttttattaataatcaaattttagaagaagat	Protospacer
*  * **.*********************.*** *

22. spacer 5.1|1366313|28|NZ_CP027287|CRISPRCasFinder matches to NZ_CP015352 (Bacillus thuringiensis strain MYBT18246 plasmid p142098, complete sequence) position: , mismatch: 7, identity: 0.75

ctcaaataattcaaactctataaacaat	CRISPR spacer
ttgaaatgattcaaactctataaaaggc	Protospacer
.* ****.**************** ...

23. spacer 5.1|1366313|28|NZ_CP027287|CRISPRCasFinder matches to NZ_CP015356 (Bacillus thuringiensis strain MYBT18246 plasmid p101287, complete sequence) position: , mismatch: 7, identity: 0.75

ctcaaataattcaaactctataaacaat	CRISPR spacer
ttgaaatgattcaaactctataaaaggc	Protospacer
.* ****.**************** ...

24. spacer 5.1|1366313|28|NZ_CP027287|CRISPRCasFinder matches to NZ_CP017256 (Clostridium taeniosporum strain 1/k plasmid pCt3, complete sequence) position: , mismatch: 7, identity: 0.75

ctcaaataattcaaactctataaacaat	CRISPR spacer
ttcaaataatacaaaatctataaaatcc	Protospacer
.********* **** ********   .

25. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NC_019765 (Stanieria cyanosphaera PCC 7437 plasmid pSTA7437.01, complete sequence) position: , mismatch: 8, identity: 0.771

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
tttcattttttatttttcctttttttctttatttt	Protospacer
*.*  . *****  *******************.*

26. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to MG592541 (Vibrio phage 1.174.O._10N.261.55.A8, partial genome) position: , mismatch: 8, identity: 0.771

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
ccttcccatctaaatttcctttttttctttgctct	Protospacer
.** .*  *.********************..***

27. spacer 3.22|727556|37|NZ_CP027287|PILER-CR matches to NZ_CP015884 (Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence) position: , mismatch: 8, identity: 0.784

caagatttctattaataatcaaattttagaggaacaa	CRISPR spacer
tattagttttattaataatcaaattttagaagaagat	Protospacer
.*  * **.*********************.*** *

28. spacer 3.39|726703|35|NZ_CP027287|CRISPRCasFinder,CRT matches to NZ_CP037749 (Campylobacter helveticus strain 2013D-9613 plasmid unnamed1) position: , mismatch: 8, identity: 0.771

ttttttcttgctgtgcgtttaaagcctcttgctgt	CRISPR spacer
tgtgttcttgctgtgcttttaaatcctctctatct	Protospacer
* * ************ ****** *****.  * *

29. spacer 3.49|727358|35|NZ_CP027287|CRISPRCasFinder,CRT matches to NC_013940 (Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence) position: , mismatch: 8, identity: 0.771

ataattattgaagaatatttttgttttagacttct	CRISPR spacer
ataattatttaagaatatttttatttgatttttta	Protospacer
********* ************.*** *  .**.

30. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 9, identity: 0.743

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
aaataaatataaaatttcctttttttctttattat	Protospacer
      ** * ********************** *

31. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031072 (Bacillus mycoides strain BPN401 plasmid pl395, complete sequence) position: , mismatch: 9, identity: 0.743

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
tatatcatttttaatttcatttttttcgattcctt	Protospacer
* ********* ****** ********  * ...*

32. spacer 3.19|727357|36|NZ_CP027287|PILER-CR matches to NC_013940 (Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence) position: , mismatch: 9, identity: 0.75

cataattattgaagaatatttttgttttagacttct	CRISPR spacer
tataattatttaagaatatttttatttgatttttta	Protospacer
.********* ************.*** *  .**.

33. spacer 3.42|726901|35|NZ_CP027287|CRISPRCasFinder,CRT matches to NZ_LR214942 (Mycoplasma orale strain NCTC10112 plasmid 3) position: , mismatch: 9, identity: 0.743

gcgattttctttaataaaattaatcgcctcgtctg	CRISPR spacer
tccgttttctttaagaaaattaattgcctctagta	Protospacer
 * .********** *********.*****   *.

34. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to AP013388 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G15, isolate: uvMED-CGR-C54-MedDCM-OCT-S36-C37) position: , mismatch: 10, identity: 0.714

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
gatgccattttaatttacctttttttctttttagg	Protospacer
  *..******** ** ************* *

35. spacer 3.12|726900|36|NZ_CP027287|PILER-CR matches to NZ_LR214942 (Mycoplasma orale strain NCTC10112 plasmid 3) position: , mismatch: 10, identity: 0.722

cgcgattttctttaataaaattaatcgcctcgtctg	CRISPR spacer
atccgttttctttaagaaaattaattgcctctagta	Protospacer
  * .********** *********.*****   *.

36. spacer 2.6|712535|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NC_020292 (Clostridium saccharoperbutylacetonicum N1-4(HMT) plasmid Csp_135p, complete sequence) position: , mismatch: 11, identity: 0.686

tctatcattttaaatttcctttttttctttattct	CRISPR spacer
ccatgtattataaattttctttttttctttaaagc	Protospacer
.*   .*** *******.*************   .

37. spacer 2.17|713259|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to MN694470 (Marine virus AFVG_250M476, complete genome) position: , mismatch: 11, identity: 0.694

cccctattaaatataaccaccaatgaaccgtcaatg	CRISPR spacer
agttcattaaatataacaaccaatgcaccgtagaat	Protospacer
  ...************ ******* ***** .*

38. spacer 2.17|713259|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to MN693658 (Marine virus AFVG_250M475, complete genome) position: , mismatch: 11, identity: 0.694

cccctattaaatataaccaccaatgaaccgtcaatg	CRISPR spacer
agttcattaaatataacaaccaatgcaccgtagaat	Protospacer
  ...************ ******* ***** .*

39. spacer 2.18|713325|36|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to AP013402 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G15, isolate: uvMED-CGR-U-MedDCM-OCT-S38-C27) position: , mismatch: 11, identity: 0.694

atatcttttacatttttaccatctgttgctaaaata	CRISPR spacer
ggttgttttacatttttaccatatgtttctattgat	Protospacer
.  * ***************** **** ***  .

40. spacer 2.40|714771|37|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 11, identity: 0.703

tagacctatatttcgtaaatttataaaagatatggtt	CRISPR spacer
tcatttatcatttcgtacatttacaaaagatatggat	Protospacer
* . ..  .******** *****.*********** *

41. spacer 1.18|706689|35|NZ_CP027287|CRISPRCasFinder matches to NC_049978 (IAS virus, complete genome) position: , mismatch: 12, identity: 0.657

tgggaagaaagagagtattattcttctcgtataag	CRISPR spacer
ctctcttaaagagagtattaatcttctggtattcc	Protospacer
.      ************* ****** ****

42. spacer 2.3|712341|35|NZ_CP027287|PILER-CR,CRISPRCasFinder,CRT matches to NC_049978 (IAS virus, complete genome) position: , mismatch: 12, identity: 0.657

tgggaagaaagagagtattattcttctcgtataag	CRISPR spacer
ctctcttaaagagagtattaatcttctggtattcc	Protospacer
.      ************* ****** ****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

320437 : 374490

Campylobacter_phage(22.73%)

tRNA,terminase,transposase,head,plate,tail,integrase

attL 338308:338326|attR 374933:374951

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023384386.1\|320437_320983_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_105459378.1\|321057_322191_+	carboxynorspermidine decarboxylase	NA	NA	NA	NA
WP_065845011.1\|322274_322874_+	sulfurtransferase-like selenium metabolism protein YedF	NA	NA	NA	NA
WP_105459379.1\|322854_323886_+	selenide, water dikinase SelD	NA	NA	NA	NA
WP_023384393.1\|323895_324522_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_058909024.1\|324532_325606_+	flagellar biosynthesis protein FlhB	NA	NA	NA	NA
WP_023384395.1\|325643_326822_-	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	3.4e-74	44.2
WP_065842817.1\|327202_330034_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	7.1e-259	50.2
WP_023384398.1\|330198_330942_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_023384399.1\|330963_331692_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_058909026.1\|332454_333333_+	hypothetical protein	NA	NA	NA	NA
WP_105459380.1\|333690_338013_-	DEAD/DEAH box helicase	A0A2H4UVA3	Bodo_saltans_virus	5.9e-31	26.8
338308:338326	attL	NA	NA	NA	NA
WP_105459381.1\|338828_339461_-	peptidase S24	M5A9D2	Nitratiruptor_phage	2.3e-21	41.8
WP_105459382.1\|339621_339837_+	hypothetical protein	NA	NA	NA	NA
WP_105459383.1\|339836_342233_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_158676883.1\|342438_342600_-	hypothetical protein	NA	NA	NA	NA
WP_105459384.1\|342603_343545_+	AAA family ATPase	NA	NA	NA	NA
WP_105459385.1\|343613_343973_+	hypothetical protein	NA	NA	NA	NA
WP_105459386.1\|344037_344406_+	DUF4406 domain-containing protein	NA	NA	NA	NA
WP_105459387.1\|344405_345026_+	DUF3164 family protein	A0A0M4TUT8	Ralstonia_phage	4.5e-25	35.3
WP_105459388.1\|345080_345266_+	hypothetical protein	NA	NA	NA	NA
WP_105459389.1\|345311_345773_+	hypothetical protein	NA	NA	NA	NA
WP_105459390.1\|345762_346653_+	hypothetical protein	NA	NA	NA	NA
WP_105459391.1\|346783_347242_+	DUF1018 domain-containing protein	NA	NA	NA	NA
WP_105459392.1\|347225_347480_+	DNA-binding protein	NA	NA	NA	NA
WP_105459393.1\|347602_347845_+	hypothetical protein	NA	NA	NA	NA
WP_105459394.1\|347936_349316_+	hypothetical protein	NA	NA	NA	NA
WP_105459395.1\|349320_349536_-	hypothetical protein	NA	NA	NA	NA
WP_105459396.1\|349936_350638_+	Rha family transcriptional regulator	X2KM03	Campylobacter_phage	2.7e-26	51.4
WP_105459397.1\|350641_350839_+	hypothetical protein	NA	NA	NA	NA
WP_105459398.1\|350929_351490_-	phage morphogenesis protein	NA	NA	NA	NA
WP_105459399.1\|351617_352865_-\|head	phage head morphogenesis protein	A0A0A1IX74	Pseudomonas_phage	3.3e-35	34.9
WP_105459400.1\|352854_354306_-	DUF935 family protein	A0A2H4JAU9	uncultured_Caudovirales_phage	7.1e-13	28.8
WP_105459401.1\|354305_355979_-\|terminase	phage terminase large subunit	R9U0T3	Rhizobium_phage	5.2e-84	35.6
WP_105459402.1\|355978_356464_-	DUF1804 family protein	NA	NA	NA	NA
WP_105459403.1\|356456_356864_-	DUF1320 family protein	NA	NA	NA	NA
WP_105459404.1\|356995_357964_-	hypothetical protein	NA	NA	NA	NA
WP_105459405.1\|358071_358503_-	hypothetical protein	NA	NA	NA	NA
WP_105459406.1\|358504_359305_-	hypothetical protein	A0A2H4JAW3	uncultured_Caudovirales_phage	2.1e-22	38.3
WP_105459407.1\|359301_359787_-	hypothetical protein	NA	NA	NA	NA
WP_105459408.1\|359946_360345_+	hypothetical protein	NA	NA	NA	NA
WP_158676884.1\|360711_361029_+	hypothetical protein	NA	NA	NA	NA
WP_105459410.1\|361015_361507_+\|plate	phage baseplate assembly protein V	R9TPT7	Vibrio_phage	7.4e-07	33.0
WP_105459411.1\|361630_361924_+\|plate	baseplate assembly protein	Q75QM0	Wolbachia_phage	3.3e-10	44.4
WP_105459593.1\|361929_363036_+\|plate	baseplate assembly protein	Q8H9N3	Vibrio_phage	9.8e-15	25.1
WP_105459412.1\|363109_363730_+\|tail	phage tail protein I	A7YGK5	Campylobacter_phage	1.8e-13	38.7
WP_105459413.1\|363716_364529_+\|tail	phage tail protein	A0A0F7LBW5	Escherichia_phage	6.7e-21	40.5
WP_105459414.1\|364534_364993_+	hypothetical protein	NA	NA	NA	NA
WP_105459415.1\|365007_365898_+	hypothetical protein	A0A067XQZ9	Caulobacter_phage	2.3e-22	30.5
WP_105459416.1\|365897_366536_+	hypothetical protein	M5AAI8	Nitratiruptor_phage	4.8e-14	49.0
WP_105459417.1\|366528_366885_+	DUF1353 domain-containing protein	B3FJY0	Pseudomonas_phage	6.0e-06	43.2
WP_158676885.1\|366872_367742_+	hypothetical protein	NA	NA	NA	NA
WP_105459419.1\|367832_369014_+\|tail	phage tail sheath family protein	A7YGT4	Campylobacter_phage	2.0e-122	57.9
WP_105459420.1\|369136_369661_+\|tail	phage tail protein	A7YGZ4	Campylobacter_phage	3.0e-30	41.9
WP_105459421.1\|369720_369975_+\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_158676886.1\|370366_372442_+\|tail	phage tail tape measure protein	A7YGE8	Campylobacter_phage	9.9e-93	32.4
WP_158676887.1\|372462_372813_+	oxidoreductase	NA	NA	NA	NA
WP_105459424.1\|372802_372994_+\|tail	phage tail protein	NA	NA	NA	NA
WP_105459425.1\|373082_373523_+	glycoside hydrolase family protein	A0A2I7R7L6	Vibrio_phage	7.9e-16	34.7
WP_105459426.1\|373524_374490_+\|tail	phage tail protein	NA	NA	NA	NA
374933:374951	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP027287

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection