CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021260	Legionella pneumophila strain NY24 (D-7706) chromosome, complete genome	3 crisprs	cas2,cas1,cas9,cas4,cas3,DEDDh,DinG,WYL,csa3	0	3	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021260_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021260_1

189550-190452

TypeII

Consensus_repeat	Method
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CRISPRCasFinder
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CRT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	PILER-CR

12 spacers

cas4,cas2,cas1,cas9

The CRISPR arrays of NZ_CP021260_1

>merge|NZ_CP021260|1|189550-190452|CRISPRCasFinder,CRT,PILER-CR
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGGAAGAAGTCAGGCTACGACCATGAAAACGATGCGACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAAGTAGAAAGCGATTATGTATATAAAACAGGTAAAAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTATCGCATATCTACGGACGCATTGCCTTATAATGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCATTGTACTATACCGGCTGGATATTAAATATTCGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTTTACGGATTCGTCGTGAATCTCCTGTTGATACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCTATAATTAGACTAGAGGAGGTTGCGGATCTTGTTGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCGTGGCACGTCCACATAATACAACCACCATTTGGGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCATTTTGACTGGTCAAACATTCAATGATTGTAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021260|1|1|189550-190452|CRISPRCasFinder
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGG	AAGAAGTCAGGCTACGACCATGAAAACGATGCGAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGTAGAAAGCGATTATGTATATAAAACAGGTAAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATCGCATATCTACGGACGCATTGCCTTATAATGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTGTACTATACCGGCTGGATATTAAATATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TTTACGGATTCGTCGTGAATCTCCTGTTGATAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTATAATTAGACTAGAGGAGGTTGCGGATCTTGTT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CGTGGCACGTCCACATAATACAACCACCATTTGGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTTTGACTGGTCAAACATTCAATGATTGTA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021260|1|1|189550-190452|CRT
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGG	AAGAAGTCAGGCTACGACCATGAAAACGATGCGAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGTAGAAAGCGATTATGTATATAAAACAGGTAAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATCGCATATCTACGGACGCATTGCCTTATAATGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTGTACTATACCGGCTGGATATTAAATATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TTTACGGATTCGTCGTGAATCTCCTGTTGATAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTATAATTAGACTAGAGGAGGTTGCGGATCTTGTT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CGTGGCACGTCCACATAATACAACCACCATTTGGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTTTGACTGGTCAAACATTCAATGATTGTA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021260|1|1|189622-190452|PILER-CR
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGTAGAAAGCGATTATGTATATAAAACAGGTAAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATCGCATATCTACGGACGCATTGCCTTATAATGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTGTACTATACCGGCTGGATATTAAATATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TTTACGGATTCGTCGTGAATCTCCTGTTGATAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTATAATTAGACTAGAGGAGGTTGCGGATCTTGTT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CGTGGCACGTCCACATAATACAACCACCATTTGGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTTTGACTGGTCAAACATTCAATGATTGTA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021260.1\|WP_062727096.1\|183913_186394_-\|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase	unknown	unknown	gnl\|CDD\|273346
NZ_CP021260.1\|WP_032830294.1\|191241_191541_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP021260.1\|WP_032832723.1\|196826_197045_-\|AlpA-family-phage-regulatory-protein	unknown	unknown	gnl\|CDD\|225848
NZ_CP021260.1\|WP_027228128.1\|188535_189201_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224885
NZ_CP021260.1\|WP_027228134.1\|197827_198778_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP021260.1\|WP_062726656.1\|192536_196655_-\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	cas9	cd09704_cas9_CAS-II-B	gnl\|CDD\|187835
NZ_CP021260.1\|WP_080274090.1\|183045_183192_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_050598121.1\|197505_197838_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_062727080.1\|199581_200775_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP021260.1\|WP_028378713.1\|187502_188372_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_028378714.1\|187174_187537_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_071974614.1\|200723_200930_-\|excisionase	unknown	unknown	unknown
NZ_CP021260.1\|WP_028378717.1\|186380_186662_-\|VirB3-family-type-IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|368285
NZ_CP021260.1\|WP_028378715.1\|186958_187162_-\|carbon-storage-regulator	unknown	unknown	gnl\|CDD\|376847
NZ_CP021260.1\|WP_028378716.1\|186671_186962_-\|TrbC/VirB2-family-protein	unknown	unknown	gnl\|CDD\|368210
NZ_CP021260.1\|WP_027228130.1\|191547_192540_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP021260.1\|WP_028378719.1\|183206_183917_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271354
NZ_CP021260.1\|WP_062726624.1\|199033_199558_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_028378720.1\|182653_183049_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_027228129.1\|190667_191261_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040

Protein	Function_ID	Function_description	E-value
NZ_CP021260.1\|WP_062727096.1\|183913_186394_-\|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase	gnl\|CDD\|273346	TIGR00929, CAG_pathogenicity_island_protein_23, type IV secretion/conjugal transfer ATPase, VirB4 family. Type IV secretion systems are found in Gram-negative pathogens. They export proteins, DNA, or complexes in different systems and are related to plasmid conjugation systems. This model represents related ATPases that include VirB4 in Agrobacterium tumefaciens (DNA export) CagE in Helicobacter pylori (protein export) and plasmid TraB (conjugation).	0
NZ_CP021260.1\|WP_032832723.1\|196826_197045_-\|AlpA-family-phage-regulatory-protein	gnl\|CDD\|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	2.21188e-05
NZ_CP021260.1\|WP_027228128.1\|188535_189201_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	1.51213e-17
NZ_CP021260.1\|WP_027228134.1\|197827_198778_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.72252e-20
NZ_CP021260.1\|WP_062726656.1\|192536_196655_-\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	gnl\|CDD\|187835	cd09704, Csx12, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	0
NZ_CP021260.1\|WP_062727080.1\|199581_200775_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.50022e-33
NZ_CP021260.1\|WP_028378717.1\|186380_186662_-\|VirB3-family-type-IV-secretion-system-protein	gnl\|CDD\|368285	pfam05101, VirB3, Type IV secretory pathway, VirB3-like protein. This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins.	9.39624e-19
NZ_CP021260.1\|WP_028378715.1\|186958_187162_-\|carbon-storage-regulator	gnl\|CDD\|376847	pfam02599, CsrA, Global regulator protein family. This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.	4.27589e-15
NZ_CP021260.1\|WP_028378716.1\|186671_186962_-\|TrbC/VirB2-family-protein	gnl\|CDD\|368210	pfam04956, TrbC, TrbC/VIRB2 family. Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species.	2.11384e-12
NZ_CP021260.1\|WP_027228130.1\|191547_192540_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.09137e-79
NZ_CP021260.1\|WP_028378719.1\|183206_183917_-\|hypothetical-protein	gnl\|CDD\|271354	cd14262, VirB5_like, VirB5 protein family. This family contains VirB5 domains, including TraC, a VirB5 homolog encoded by the pKM101 plasmid, and similar proteins. VirB5 is one of 11 conserved proteins (VirB1-VirB11) in Agrobacterium tumefaciens, the causative agent of crown gall disease, that span the inner and the outer membrane, and is involved in type IV DNA secretion systems (T4SS) which mediate the translocation of virulence factors (proteins and/or DNA) from Gram-negative bacteria into eukaryotic cells. VirB5 assembles extracellular pili by interacting with several essential proteins. VirB2-VirB5 complex formation precedes incorporation into pili; it depends on the inner membrane protein VirB4 to interact directly with and stabilize VirB8 in order for VirB5 to bind to VirB8 and VirB10. Mutagenesis studies show that VirB5 proteins participate in protein-protein interactions important for pilus assembly and function.	1.7025e-17
NZ_CP021260.1\|WP_032830294.1\|191241_191541_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.31074e-05
NZ_CP021260.1\|WP_027228129.1\|190667_191261_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	4.12817e-15

>NZ_CP021260.1|WP_027228128.1|188535_189201_+|helix-turn-helix-domain-containing-protein
MNIKKEIGKRILEARKAKGLTLKALGELAGGLKQTRLTNWEQGVRTPGPEEIKSLAQALDVSPAYLMCLSDEKRFKEVQSPSQLVPLLTHYQACEALLHIQTIREQENPNNITLISVSMALLPVLSADAFALKMLDDSMIPEIRINDIQVIDPNAQPNPGDYVAVKVRGKEEAIICVYKKLSYTSSQFELLTLNDNWPDIKVSDIAEVNILGKLVLNIRTY
>NZ_CP021260.1|WP_028378713.1|187502_188372_-|hypothetical-protein
MMDFVINGDELEAMCGLPHIQQLTYLRGIRPYMDVKTGIVGIKRRISHQSISEQLYVEPHQGIKNQSFSRDQVRRAVSGLVRAGLIEVQSEGMHLILKCLLASQHYSVQNKAAINPPQKATIKPREESLENTGLSEVEALKADTVEPPKAAIPHKDNYYIYLLSQFEKFWSLYPEKKSRNNAQAVFEELNPDAELFHTIINALNAQINHRETMKLQGTWVPPWKYPANWLAQRCWEDELPTDALQEKHHAEHTKNTRKRHTTEDLFCPPCDVEERGNNNVIQLQRYLQS
>NZ_CP021260.1|WP_028378714.1|187174_187537_-|hypothetical-protein
MSSSSKDTFKAERRIDLLFSKFAAFYGHVWRSQFKDEVFLRFAKKEWQEALADFTDAVLAKAILNCREFYELPPTLPQMLYCCRQIRKQVTFYVIKDEYQPANKAVVSSCLQKCKELLAK
>NZ_CP021260.1|WP_028378715.1|186958_187162_-|carbon-storage-regulator
MLVLTRKAGQQILIGKGLIQMKVLKVDDDIISIGIKAPQHIDIDREEIYLKKLQKEQAESSLQKVAL
>NZ_CP021260.1|WP_028378716.1|186671_186962_-|TrbC/VirB2-family-protein
MSKFNRLSQSISDLYLVAVCTLLPSLSHAQSIESIINRTINYLQGGLARTVGVFCIIIAGYLCLARQKFPKEYFVMILVGMGIIFGGSSLYSTLIG
>NZ_CP021260.1|WP_028378717.1|186380_186662_-|VirB3-family-type-IV-secretion-system-protein
MSDLEISPIFNALTRPAMIAGVTFEYHMLNLIVSMCVFIGLSPLYGLIFIPLHVFGWLVCRYDTHFFTICAKRYLLPEAPNASIWRVRAYEPF
>NZ_CP021260.1|WP_062727096.1|183913_186394_-|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase
MNLSKTLKQVYQEAKVSDLFPITHLNTPSIFESQSGFVGSVLKVDGAAFEIEEADTLNHQRFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTLYITVILKGDDSSKTGSWLQWAKRFSIQGNSELAEHHREQNIQTLNRAVEQLQANLAPFRASLLGQQDDALGFSELLQFLGLVVNAGHPALFKHPFYSPPIANSIPNTFKHETRYPEGHIGQYLSGCQILFGECIQFQGNTQDDCLFGAMLSLKKYPTNTASILLDSLLSLDCEFIATHTFAPIGRDSALDTISKKRSKLLSAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPSQSLLDAAILEATKRYGSAGIVVVKETLGQEPAFWSQLPCNQHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTLVNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKVEPSNPIAMNPLQLPDTAENRSFLKSWFATLVQEEGERVIPSDIAEIINDCIDYNFEQLAPEFRTLSYLSQFLPVDFPRWPHLRRWLKRNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTYFMDQVQSIIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKCLKEWLPTIRKKNGHFIFDTQSPKTITDSPIKHIVLDNLATLIAFPNPLADRETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKLDLSGLSQYIRVLSANTQSVKLLDEIIEEVGQEPELWLPVFFERSNK
>NZ_CP021260.1|WP_028378719.1|183206_183917_-|hypothetical-protein
MKRTACFLIAALSLSSVSHADILGVEDAQLILLAMKQLSELQEQYRVLSDTYQTAKNQLDNLNQLKSMNSGHYGFGDINNSLDSLQSWQSPVSTWQDALQNLSGGNQQRYQALVDAYEKNHPALDEASYSRFTTPANAMRFKEDKAVNRAVMVQTTESYNEINKHMEALHKLSQQIEKTPNTKGAIDLNSRLITEIGFIQLMSLRLQALISQQSAQENLSALQDRAEMAKFNRLPK
>NZ_CP021260.1|WP_080274090.1|183045_183192_-|hypothetical-protein
MKWLLSVLMMVVLSGCSKPPDLDSPCHHFGQYCPQYPINDEPIMELTK
>NZ_CP021260.1|WP_028378720.1|182653_183049_-|hypothetical-protein
MNHLLKSLMVVLMAAAISACQHENPLKTQPAKTSVTFLINASANAEKRLHFAIHKDAYGFAYLECMEGKQSPEIRCDALYQGMIAFAKEGHYSGFQKITLADLTDKNLFESLADEYAETAATTWPHLVSGT
>NZ_CP021260.1|WP_027228129.1|190667_191261_-|CRISPR-associated-protein-Cas4
MDTSSYKLPVNMIRQYCFCPRIVYYHMVIGLKVAYPGWVQYGEEYQHKQQILDKRRTLSKFKPISEQAILRQNTMLEHPSYPFYGICDGIIEDELEIIPIELKSFASKISLGQKMQLTAYGMLSELIFEKSCTRGYIITGEKAKAKLIKIDEKSKFKVLEIYAKIKKIFDTETLPYSTANGLQCIQCEFLNHCNDRF
>NZ_CP021260.1|WP_032830294.1|191241_191541_-|CRISPR-associated-endonuclease-Cas2
MQTRLYKEYIVSYDIRDNSIRRTIYERLKDIGLTPVQKSVFWGYLNEPEKRYLTNVLKKELAKQDTAFITPCKLTQEYEVNLINLELDELRKPDGHIIV
>NZ_CP021260.1|WP_027228130.1|191547_192540_-|CRISPR-associated-endonuclease-Cas1
MKHLTLSEQGSSCKLQGERILVFNKDHMVFEGTLNRLKTISIAKQGVTLTSNLLVACAMRGIQIFILDYSGKAVCSLQGGLHRTAKVRENQFKYIYTKEASNMAARFILAKIKNQSAVLKYFAKAKNRPENEKIILHTASQKIAGIVSNITETNWIKLQDWRFTLLGFEGSAAKIYWETVKEVNLVCSDFEGRRPRVNKDITNSMLNYAYSILSSWVWQAITNAGLELYAGILHTSKPGKPSLVLDLMEEFRPWCADRIIFKLRARAQKQNELTPALKKALIDEMANLYAKPLPYHKRRISLESIIQRQVYHLSAVFSGEGKYKGYLFKW
>NZ_CP021260.1|WP_062726656.1|192536_196655_-|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12
MESSQLLSPIGIDLGGKFTGVCLSHLESFAELPNHANTKYSVILMDHNNFQLSQAQRRITRHRVRNKKRNQFVKRVALQLFQHMLSRELNVKEEIALCHYLNNRGYTYVDTDLDEYLKDETTVNLLKELLPPESEHNFIDWLLQKMQSSKFREILGSRVEEKKDDKELKNAVKNIKNFITGFEKNSVEGHRHRKVYFENIKSDITNDNQLDGIKKKIPSVCLSNLLGHLSNLQWKNLHRYLAKNPKQFDEQTFGNEFLRMLKNFKHLKGSQESLAVRDLIQQLEQSKDYISILEKTPPEITIPPYEARTNTGMEKDQSLLLNPEKLNNLYPKWRNLIPGIIDAHPFLEKDLEHTKLRDRKRIISPSKQDEKRDSYILQRYLDLNKKIDKFKIKKQLSFLGQGKQLPANLIETHKEMETHFSSSLVSALIQIASAYNKEREDAAQGIWFDNAFSLCELSNINPPRKQKILPLLVGAILSEDFINNKDKWAKFKSFWNTHKIGRTLLKYKCKEIEEARKNSGNAFKIDYEEALNHPEHSNNKALTKIIQTIPDIIQAIQSHLGHNDSQALIYNNPFSLSQLYTILETKRDGFHKNCVAVTCENYWRSQKTEIDPEISYASRLPADSVRPFDGVLARMMQRLAYEIAMAKWEQIKHIPDNSSLLIPIYLEQNRFEFEESFKKIKGISRDKTLEQAIEKQNIRWEEKFQRIINASMNVCPYKGTLIGGQGEIDHIYPRSLSKKHFGTIFNSEANLIYCSSQGNREKKEEHYLLEHLSPIYLKHQFGTDNVSDIKNFISQNVANIKKYISFHLLTPEQQKAARHALFLDYDDEAFKTVTKFLMSQQKARVNGTQKFLGKQIMEFLSTLADSKQLQLEFSIKQINAEEVHNHRELLSKQEPKLAKSQQQSFPSHAIDATLTMGIGLKEFPQFSQELDNSWFINHLMPDEVHLNPVQSKEKYNKPNISSTPLFKDSLYAERFIPVWVKGETFAIGFSEKDLFEIKPSNKEKLFTLLKTYSTKNPGESLQELQAISKAKWLYFPINKTLALEFLHHYFHKETVTPDDTTVCHFINSLRYYTKKESITVKILKESMPVLSVRFESSKKNVLGTFKHTIALPATKDWERLFNHPNFLALKANPNPNPKEFNEFIKKYFLSENNPNSDIPNNDHTIKPQKHKTVRKVFSLPVIPGNAGTMMRIRRKDNKGQPLYQLQTIDDTPSMGIQINEGKLVKQEVLMDAYKTRNLSTIDGINNSERQAYAAFDNWLTLPVSTFKPEIIKLEMKPHSKTRRYIRITQSLADFIKTIDEALMIKPSDSIDDPLNMPNEIVCKNKLFGNELKPRDGKMKIVSTGKTVTYEFESDSTPQWIQKLYVTQLKKHP
>NZ_CP021260.1|WP_032832723.1|196826_197045_-|AlpA-family-phage-regulatory-protein
MTKLPEIGFLRANQIIGDKNANPPIPALIPVGKSTWWAGVKSGRFPKPIKFGSRITVWRVEDIREFIEKASL
>NZ_CP021260.1|WP_050598121.1|197505_197838_+|hypothetical-protein
MASPRQISRCFADLVEMGKLVKIGYGIYAKAYRSEYLNKPVIKGGFSQICKEALTKLGVEWIPGSAEQAYNSGLSTQVPVRTIVQLKSRFRGHLKYGNRQLVVEKGINAR
>NZ_CP021260.1|WP_027228134.1|197827_198778_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MLGKPLLELITTTGEILELEDLVIEKDYYVAQVINALSKVENDYFRLVFCGGTCLAKAHKVIYRMSEDIDFKIQIKEIDEHLSKTRLLKELKIFRSLIQSKLTHLDLSIGNTVVRNEGQYSRIELDYPSVFPFNSRLRPHILLEFTLSNIRLATSSLPIKTLIEETLENIILFAPCFTHCISVNETAIEKWAGLTRRVVAIERNYHPDDETLIRHVYDLNAIKQASKIDENFFTLAKTIVSNDAKQFKNQHPEYADNPSEEIKQSLSLLKNKLIWKARYQEFIETMVYDNINTIDYETAIANIEHISTKIMGFLSE
>NZ_CP021260.1|WP_062726624.1|199033_199558_+|hypothetical-protein
MTFEVFSASYANGVTAVVAVMALLTACITLWFLKRDHALKYRPYLMPAVNVDRQCDKLIVSIKPCNVGLHPCKAKIYDIKLIIGDETFPTPDVQELLLSPVRVGVSIPAGYINDIGVNRIRQGQYKKNRIELNFIIESKSIENKYKCIQKYSFEISVLDEHVQAFIRPEWIENI
>NZ_CP021260.1|WP_062727080.1|199581_200775_-|site-specific-integrase
MGGKRRSGDTPKTPAGIEIRRWSSGKTTLRISFYYKGVQCRETLKLEVTPSNIKYAERLRCEILNTIERGTFSYADYFPQSNLARRFGHVKTNITIGELLRDFLDQIHATREHSTYIGYKKVCEAHLIPYFGEVALQDLKPAFIREWIRGLRVTSKTVSNLLIPLRAIIEQALNDEYIKSNPLDKIVISKLLSKQTSKSTFKVDPFDKIEVKAILEATHHEQIRNLFQFAFFSGLRTSELIALEWGDIDLAHGIINVVRAVVKKQIKGTKTIAGKRQVMLLPPAIEALNAQMKYTFNIGERVFHNPRTNQPWETDHQIRRTAWVHTMKRAGVRYRNPYQTRHTYASMMLSGGENIMWVASQMGHVDTEMVMKTYGKWIPNDTSKKGYQTINNWETYI
>NZ_CP021260.1|WP_071974614.1|200723_200930_-|excisionase
MKWVKLKKYCQDTGDTTNAVHCKRKRGMWLDGLHCKLGPDGNLWINLVEVERWVENGDQATLQKLQQA

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Crispr_ID: NZ_CP021260_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021260_2

224773-225675

TypeII

Consensus_repeat	Method
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CRISPRCasFinder
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CRT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	PILER-CR

12 spacers

cas4,cas2,cas1,cas9

The CRISPR arrays of NZ_CP021260_2

>merge|NZ_CP021260|2|224773-225675|CRISPRCasFinder,CRT,PILER-CR
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGGAAGAAGTCAGGCTACGACCATGAAAACGATGCGACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAAGTAGAAAGCGATTATGTATATAAAACAGGTAAAAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTATCGCATATCTACGGACGCATTGCCTTATAATGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCATTGTACTATACCGGCTGGATATTAAATATTCGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTTTACGGATTCGTCGTGAATCTCCTGTTGATACGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCTATAATTAGACTAGAGGAGGTTGCGGATCTTGTTGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCGTGGCACGTCCACATAATACAACCACCATTTGGGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGCATTTTGACTGGTCAAACATTCAATGATTGTAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGAGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGAGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGGTGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAGGTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021260|2|2|224773-225675|CRISPRCasFinder
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGG	AAGAAGTCAGGCTACGACCATGAAAACGATGCGAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGTAGAAAGCGATTATGTATATAAAACAGGTAAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATCGCATATCTACGGACGCATTGCCTTATAATGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTGTACTATACCGGCTGGATATTAAATATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TTTACGGATTCGTCGTGAATCTCCTGTTGATAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTATAATTAGACTAGAGGAGGTTGCGGATCTTGTT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CGTGGCACGTCCACATAATACAACCACCATTTGGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTTTGACTGGTCAAACATTCAATGATTGTA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021260|2|2|224773-225675|CRT
ATTTCATTAGTTAAATTTTTAGATGGGGGATTTTTGG	AAGAAGTCAGGCTACGACCATGAAAACGATGCGAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGTAGAAAGCGATTATGTATATAAAACAGGTAAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATCGCATATCTACGGACGCATTGCCTTATAATGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTGTACTATACCGGCTGGATATTAAATATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TTTACGGATTCGTCGTGAATCTCCTGTTGATAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTATAATTAGACTAGAGGAGGTTGCGGATCTTGTT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CGTGGCACGTCCACATAATACAACCACCATTTGGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTTTGACTGGTCAAACATTCAATGATTGTA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

>NZ_CP021260|2|2|224845-225675|PILER-CR
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AAGTAGAAAGCGATTATGTATATAAAACAGGTAAAA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TATCGCATATCTACGGACGCATTGCCTTATAATGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TCAGGGAGGGGCAGTGAAAATTATGGCAAACAAGAAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTGTACTATACCGGCTGGATATTAAATATTC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TTTACGGATTCGTCGTGAATCTCCTGTTGATAC
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CTATAATTAGACTAGAGGAGGTTGCGGATCTTGTT
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATCGTTTACAGGCGTTTTTACGTTAAGGGATATAACCA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CGTGGCACGTCCACATAATACAACCACCATTTGGG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	CATTTTGACTGGTCAAACATTCAATGATTGTA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	AGCAGTCGTTGCGGTTACGGCATAACCAGCTGCAGA
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG	TGTTTGAACAAGACGTTCAATTGCAAAGCTCCGCAG
GTTTCAGTGGTTGGATTTTTAGATGAGGGATTATTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021260.1\|WP_080464381.1\|235554_236514_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP021260.1\|WP_028378715.1\|222181_222385_-\|carbon-storage-regulator	unknown	unknown	gnl\|CDD\|376847
NZ_CP021260.1\|WP_028378716.1\|221894_222185_-\|TrbC/VirB2-family-protein	unknown	unknown	gnl\|CDD\|368210
NZ_CP021260.1\|WP_028378720.1\|217876_218272_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_028378719.1\|218429_219140_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271354
NZ_CP021260.1\|WP_061820091.1\|234265_235441_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP021260.1\|WP_080274090.1\|218268_218415_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_027228128.1\|223758_224424_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224885
NZ_CP021260.1\|WP_032832723.1\|232049_232268_-\|AlpA-family-phage-regulatory-protein	unknown	unknown	gnl\|CDD\|225848
NZ_CP021260.1\|WP_032830294.1\|226464_226764_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP021260.1\|WP_028378717.1\|221603_221885_-\|VirB3-family-type-IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|368285
NZ_CP021260.1\|WP_027228129.1\|225890_226484_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_CP021260.1\|WP_028378714.1\|222397_222760_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_062727813.1\|236570_236855_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_027228130.1\|226770_227763_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP021260.1\|WP_027228134.1\|233050_234001_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP021260.1\|WP_062727096.1\|219136_221617_-\|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase	unknown	unknown	gnl\|CDD\|273346
NZ_CP021260.1\|WP_062726656.1\|227759_231878_-\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	cas9	cd09704_cas9_CAS-II-B	gnl\|CDD\|187835
NZ_CP021260.1\|WP_028378713.1\|222725_223595_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_050598121.1\|232728_233061_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP021260.1\|WP_080464381.1\|235554_236514_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	1.08433e-62
NZ_CP021260.1\|WP_028378715.1\|222181_222385_-\|carbon-storage-regulator	gnl\|CDD\|376847	pfam02599, CsrA, Global regulator protein family. This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.	4.27589e-15
NZ_CP021260.1\|WP_028378716.1\|221894_222185_-\|TrbC/VirB2-family-protein	gnl\|CDD\|368210	pfam04956, TrbC, TrbC/VIRB2 family. Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure. This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species.	2.11384e-12
NZ_CP021260.1\|WP_028378719.1\|218429_219140_-\|hypothetical-protein	gnl\|CDD\|271354	cd14262, VirB5_like, VirB5 protein family. This family contains VirB5 domains, including TraC, a VirB5 homolog encoded by the pKM101 plasmid, and similar proteins. VirB5 is one of 11 conserved proteins (VirB1-VirB11) in Agrobacterium tumefaciens, the causative agent of crown gall disease, that span the inner and the outer membrane, and is involved in type IV DNA secretion systems (T4SS) which mediate the translocation of virulence factors (proteins and/or DNA) from Gram-negative bacteria into eukaryotic cells. VirB5 assembles extracellular pili by interacting with several essential proteins. VirB2-VirB5 complex formation precedes incorporation into pili; it depends on the inner membrane protein VirB4 to interact directly with and stabilize VirB8 in order for VirB5 to bind to VirB8 and VirB10. Mutagenesis studies show that VirB5 proteins participate in protein-protein interactions important for pilus assembly and function.	1.7025e-17
NZ_CP021260.1\|WP_061820091.1\|234265_235441_-\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	3.02312e-68
NZ_CP021260.1\|WP_027228128.1\|223758_224424_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	1.51213e-17
NZ_CP021260.1\|WP_032832723.1\|232049_232268_-\|AlpA-family-phage-regulatory-protein	gnl\|CDD\|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	2.21188e-05
NZ_CP021260.1\|WP_032830294.1\|226464_226764_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.31074e-05
NZ_CP021260.1\|WP_028378717.1\|221603_221885_-\|VirB3-family-type-IV-secretion-system-protein	gnl\|CDD\|368285	pfam05101, VirB3, Type IV secretory pathway, VirB3-like protein. This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins.	9.39624e-19
NZ_CP021260.1\|WP_027228129.1\|225890_226484_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	4.12817e-15
NZ_CP021260.1\|WP_027228130.1\|226770_227763_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.09137e-79
NZ_CP021260.1\|WP_027228134.1\|233050_234001_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.72252e-20
NZ_CP021260.1\|WP_062727096.1\|219136_221617_-\|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase	gnl\|CDD\|273346	TIGR00929, CAG_pathogenicity_island_protein_23, type IV secretion/conjugal transfer ATPase, VirB4 family. Type IV secretion systems are found in Gram-negative pathogens. They export proteins, DNA, or complexes in different systems and are related to plasmid conjugation systems. This model represents related ATPases that include VirB4 in Agrobacterium tumefaciens (DNA export) CagE in Helicobacter pylori (protein export) and plasmid TraB (conjugation).	0
NZ_CP021260.1\|WP_062726656.1\|227759_231878_-\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	gnl\|CDD\|187835	cd09704, Csx12, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	0

>NZ_CP021260.1|WP_027228128.1|223758_224424_+|helix-turn-helix-domain-containing-protein
MNIKKEIGKRILEARKAKGLTLKALGELAGGLKQTRLTNWEQGVRTPGPEEIKSLAQALDVSPAYLMCLSDEKRFKEVQSPSQLVPLLTHYQACEALLHIQTIREQENPNNITLISVSMALLPVLSADAFALKMLDDSMIPEIRINDIQVIDPNAQPNPGDYVAVKVRGKEEAIICVYKKLSYTSSQFELLTLNDNWPDIKVSDIAEVNILGKLVLNIRTY
>NZ_CP021260.1|WP_028378713.1|222725_223595_-|hypothetical-protein
MMDFVINGDELEAMCGLPHIQQLTYLRGIRPYMDVKTGIVGIKRRISHQSISEQLYVEPHQGIKNQSFSRDQVRRAVSGLVRAGLIEVQSEGMHLILKCLLASQHYSVQNKAAINPPQKATIKPREESLENTGLSEVEALKADTVEPPKAAIPHKDNYYIYLLSQFEKFWSLYPEKKSRNNAQAVFEELNPDAELFHTIINALNAQINHRETMKLQGTWVPPWKYPANWLAQRCWEDELPTDALQEKHHAEHTKNTRKRHTTEDLFCPPCDVEERGNNNVIQLQRYLQS
>NZ_CP021260.1|WP_028378714.1|222397_222760_-|hypothetical-protein
MSSSSKDTFKAERRIDLLFSKFAAFYGHVWRSQFKDEVFLRFAKKEWQEALADFTDAVLAKAILNCREFYELPPTLPQMLYCCRQIRKQVTFYVIKDEYQPANKAVVSSCLQKCKELLAK
>NZ_CP021260.1|WP_028378715.1|222181_222385_-|carbon-storage-regulator
MLVLTRKAGQQILIGKGLIQMKVLKVDDDIISIGIKAPQHIDIDREEIYLKKLQKEQAESSLQKVAL
>NZ_CP021260.1|WP_028378716.1|221894_222185_-|TrbC/VirB2-family-protein
MSKFNRLSQSISDLYLVAVCTLLPSLSHAQSIESIINRTINYLQGGLARTVGVFCIIIAGYLCLARQKFPKEYFVMILVGMGIIFGGSSLYSTLIG
>NZ_CP021260.1|WP_028378717.1|221603_221885_-|VirB3-family-type-IV-secretion-system-protein
MSDLEISPIFNALTRPAMIAGVTFEYHMLNLIVSMCVFIGLSPLYGLIFIPLHVFGWLVCRYDTHFFTICAKRYLLPEAPNASIWRVRAYEPF
>NZ_CP021260.1|WP_062727096.1|219136_221617_-|VirB4-family-type-IV-secretion/conjugal-transfer-ATPase
MNLSKTLKQVYQEAKVSDLFPITHLNTPSIFESQSGFVGSVLKVDGAAFEIEEADTLNHQRFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTLYITVILKGDDSSKTGSWLQWAKRFSIQGNSELAEHHREQNIQTLNRAVEQLQANLAPFRASLLGQQDDALGFSELLQFLGLVVNAGHPALFKHPFYSPPIANSIPNTFKHETRYPEGHIGQYLSGCQILFGECIQFQGNTQDDCLFGAMLSLKKYPTNTASILLDSLLSLDCEFIATHTFAPIGRDSALDTISKKRSKLLSAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPSQSLLDAAILEATKRYGSAGIVVVKETLGQEPAFWSQLPCNQHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTLVNFLDAQMGRFGGRSFFIDRDESSKIYVLASGNSSYIKVEPSNPIAMNPLQLPDTAENRSFLKSWFATLVQEEGERVIPSDIAEIINDCIDYNFEQLAPEFRTLSYLSQFLPVDFPRWPHLRRWLKRNDSRIDGEFHWLFDNPNDALNLDFDKVGFDVTYFMDQVQSIIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKCLKEWLPTIRKKNGHFIFDTQSPKTITDSPIKHIVLDNLATLIAFPNPLADRETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKLDLSGLSQYIRVLSANTQSVKLLDEIIEEVGQEPELWLPVFFERSNK
>NZ_CP021260.1|WP_028378719.1|218429_219140_-|hypothetical-protein
MKRTACFLIAALSLSSVSHADILGVEDAQLILLAMKQLSELQEQYRVLSDTYQTAKNQLDNLNQLKSMNSGHYGFGDINNSLDSLQSWQSPVSTWQDALQNLSGGNQQRYQALVDAYEKNHPALDEASYSRFTTPANAMRFKEDKAVNRAVMVQTTESYNEINKHMEALHKLSQQIEKTPNTKGAIDLNSRLITEIGFIQLMSLRLQALISQQSAQENLSALQDRAEMAKFNRLPK
>NZ_CP021260.1|WP_080274090.1|218268_218415_-|hypothetical-protein
MKWLLSVLMMVVLSGCSKPPDLDSPCHHFGQYCPQYPINDEPIMELTK
>NZ_CP021260.1|WP_028378720.1|217876_218272_-|hypothetical-protein
MNHLLKSLMVVLMAAAISACQHENPLKTQPAKTSVTFLINASANAEKRLHFAIHKDAYGFAYLECMEGKQSPEIRCDALYQGMIAFAKEGHYSGFQKITLADLTDKNLFESLADEYAETAATTWPHLVSGT
>NZ_CP021260.1|WP_027228129.1|225890_226484_-|CRISPR-associated-protein-Cas4
MDTSSYKLPVNMIRQYCFCPRIVYYHMVIGLKVAYPGWVQYGEEYQHKQQILDKRRTLSKFKPISEQAILRQNTMLEHPSYPFYGICDGIIEDELEIIPIELKSFASKISLGQKMQLTAYGMLSELIFEKSCTRGYIITGEKAKAKLIKIDEKSKFKVLEIYAKIKKIFDTETLPYSTANGLQCIQCEFLNHCNDRF
>NZ_CP021260.1|WP_032830294.1|226464_226764_-|CRISPR-associated-endonuclease-Cas2
MQTRLYKEYIVSYDIRDNSIRRTIYERLKDIGLTPVQKSVFWGYLNEPEKRYLTNVLKKELAKQDTAFITPCKLTQEYEVNLINLELDELRKPDGHIIV
>NZ_CP021260.1|WP_027228130.1|226770_227763_-|CRISPR-associated-endonuclease-Cas1
MKHLTLSEQGSSCKLQGERILVFNKDHMVFEGTLNRLKTISIAKQGVTLTSNLLVACAMRGIQIFILDYSGKAVCSLQGGLHRTAKVRENQFKYIYTKEASNMAARFILAKIKNQSAVLKYFAKAKNRPENEKIILHTASQKIAGIVSNITETNWIKLQDWRFTLLGFEGSAAKIYWETVKEVNLVCSDFEGRRPRVNKDITNSMLNYAYSILSSWVWQAITNAGLELYAGILHTSKPGKPSLVLDLMEEFRPWCADRIIFKLRARAQKQNELTPALKKALIDEMANLYAKPLPYHKRRISLESIIQRQVYHLSAVFSGEGKYKGYLFKW
>NZ_CP021260.1|WP_062726656.1|227759_231878_-|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12
MESSQLLSPIGIDLGGKFTGVCLSHLESFAELPNHANTKYSVILMDHNNFQLSQAQRRITRHRVRNKKRNQFVKRVALQLFQHMLSRELNVKEEIALCHYLNNRGYTYVDTDLDEYLKDETTVNLLKELLPPESEHNFIDWLLQKMQSSKFREILGSRVEEKKDDKELKNAVKNIKNFITGFEKNSVEGHRHRKVYFENIKSDITNDNQLDGIKKKIPSVCLSNLLGHLSNLQWKNLHRYLAKNPKQFDEQTFGNEFLRMLKNFKHLKGSQESLAVRDLIQQLEQSKDYISILEKTPPEITIPPYEARTNTGMEKDQSLLLNPEKLNNLYPKWRNLIPGIIDAHPFLEKDLEHTKLRDRKRIISPSKQDEKRDSYILQRYLDLNKKIDKFKIKKQLSFLGQGKQLPANLIETHKEMETHFSSSLVSALIQIASAYNKEREDAAQGIWFDNAFSLCELSNINPPRKQKILPLLVGAILSEDFINNKDKWAKFKSFWNTHKIGRTLLKYKCKEIEEARKNSGNAFKIDYEEALNHPEHSNNKALTKIIQTIPDIIQAIQSHLGHNDSQALIYNNPFSLSQLYTILETKRDGFHKNCVAVTCENYWRSQKTEIDPEISYASRLPADSVRPFDGVLARMMQRLAYEIAMAKWEQIKHIPDNSSLLIPIYLEQNRFEFEESFKKIKGISRDKTLEQAIEKQNIRWEEKFQRIINASMNVCPYKGTLIGGQGEIDHIYPRSLSKKHFGTIFNSEANLIYCSSQGNREKKEEHYLLEHLSPIYLKHQFGTDNVSDIKNFISQNVANIKKYISFHLLTPEQQKAARHALFLDYDDEAFKTVTKFLMSQQKARVNGTQKFLGKQIMEFLSTLADSKQLQLEFSIKQINAEEVHNHRELLSKQEPKLAKSQQQSFPSHAIDATLTMGIGLKEFPQFSQELDNSWFINHLMPDEVHLNPVQSKEKYNKPNISSTPLFKDSLYAERFIPVWVKGETFAIGFSEKDLFEIKPSNKEKLFTLLKTYSTKNPGESLQELQAISKAKWLYFPINKTLALEFLHHYFHKETVTPDDTTVCHFINSLRYYTKKESITVKILKESMPVLSVRFESSKKNVLGTFKHTIALPATKDWERLFNHPNFLALKANPNPNPKEFNEFIKKYFLSENNPNSDIPNNDHTIKPQKHKTVRKVFSLPVIPGNAGTMMRIRRKDNKGQPLYQLQTIDDTPSMGIQINEGKLVKQEVLMDAYKTRNLSTIDGINNSERQAYAAFDNWLTLPVSTFKPEIIKLEMKPHSKTRRYIRITQSLADFIKTIDEALMIKPSDSIDDPLNMPNEIVCKNKLFGNELKPRDGKMKIVSTGKTVTYEFESDSTPQWIQKLYVTQLKKHP
>NZ_CP021260.1|WP_032832723.1|232049_232268_-|AlpA-family-phage-regulatory-protein
MTKLPEIGFLRANQIIGDKNANPPIPALIPVGKSTWWAGVKSGRFPKPIKFGSRITVWRVEDIREFIEKASL
>NZ_CP021260.1|WP_050598121.1|232728_233061_+|hypothetical-protein
MASPRQISRCFADLVEMGKLVKIGYGIYAKAYRSEYLNKPVIKGGFSQICKEALTKLGVEWIPGSAEQAYNSGLSTQVPVRTIVQLKSRFRGHLKYGNRQLVVEKGINAR
>NZ_CP021260.1|WP_027228134.1|233050_234001_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MLGKPLLELITTTGEILELEDLVIEKDYYVAQVINALSKVENDYFRLVFCGGTCLAKAHKVIYRMSEDIDFKIQIKEIDEHLSKTRLLKELKIFRSLIQSKLTHLDLSIGNTVVRNEGQYSRIELDYPSVFPFNSRLRPHILLEFTLSNIRLATSSLPIKTLIEETLENIILFAPCFTHCISVNETAIEKWAGLTRRVVAIERNYHPDDETLIRHVYDLNAIKQASKIDENFFTLAKTIVSNDAKQFKNQHPEYADNPSEEIKQSLSLLKNKLIWKARYQEFIETMVYDNINTIDYETAIANIEHISTKIMGFLSE
>NZ_CP021260.1|WP_061820091.1|234265_235441_-|ISL3-family-transposase
MPKHDVILNLPGFTIKKVSGYQPLLLDLTYKRLPRCSHCSSKKVRKKSSYERKVHHELIGHRRTILRFKAYKLFCNECGRYGNQQFPGIAKYQRSTERLQVQIFHHHTSGISQKELSLQFKQGKATIERWYHRRYQIEGNELLNTPCPKVLGLDEHFFSRKHGFATTLCDLKKHKVFDIVKGRREVDLNHYLNSLKGKDRVQVVCMDLSSTYRSLVKKHFPNAQIVADRFHVIRLVQHQCMMTYRELSSSIKNNRGLLALLRTKPDKLTPHKKIKRDSFLAENPAIEAIYHFQQQLHELLMNKTLTKVRCRKIIPLFLKMIQDLKQSPFKSLVALGKTLDSWKEEIACMWRFSKSNGITEGFHRKMKLIQRRAYGFRNFENYRLRVRVLCA
>NZ_CP021260.1|WP_080464381.1|235554_236514_+|Fic-family-protein
MYIRKEAVLSSQIEGTQSSLSDLLLYENQETQGVPDQDVVEVSNYVAAIEHGLERIKNGFPLSLRLIREMHEILLNKGRGSSKQPGEFRRSQNWIGGTRPGNAKFVPPPPERLIETLDALEKFLHDETIKLPTLVKAALAHHQFETIHPFLDGNGRLGRLLITFILCVDGIMEQPMLYLSLYFKTHRQQYYDHLQLVRDTGDWEEWLQFFLKGVVETANQAVSTAQAILTLFREDRKQIELAGKLAPSLLLVHYYLQKHPTTDSKKVMKNCNISLPTANSALNYLLKIGIVKEITGRARNKIYVYQKYLGILSEGALPY
>NZ_CP021260.1|WP_062727813.1|236570_236855_-|hypothetical-protein
MNLKIPYVDHAGFLRNYIPDFVVKTPNIMLIVETKGRVDIVVAAKDAQMKRWTKMVSERTKEHWQFLRVNQNDFDGGGYNSIHDFLILASKQKH

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Crispr_ID: NZ_CP021260_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021260_3

3212630-3212732

Orphan

Consensus_repeat	Method
CTGAGATAAAAAAAGAGTTTATAGACAACAAACTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP021260_3

>merge|NZ_CP021260|3|3212630-3212732|CRISPRCasFinder
CTGAGATAAAAAAAGAGTTTATAGACAACAAACTAGTTCTATTATTATATCTAACTATTGCAAAATTCTGAGATAAAAAAAGAGTTTATAGACAACAAACTAG

>NZ_CP021260|3|3|3212630-3212732|CRISPRCasFinder
CTGAGATAAAAAAAGAGTTTATAGACAACAAACTAG	TTCTATTATTATATCTAACTATTGCAAAATT
CTGAGATAAAAAAAGAGTTTATAGACAACAAACTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021260.1\|WP_062726417.1\|3202186_3205288_-\|type-IVB-secretion-system-protein-DotA	unknown	unknown	gnl\|CDD\|275142
NZ_CP021260.1\|WP_027229023.1\|3222585_3222981_-\|ClpXP-protease-specificity-enhancing-factor	unknown	unknown	gnl\|CDD\|236987
NZ_CP021260.1\|WP_062726419.1\|3207717_3209358_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_062726423.1\|3216277_3217219_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_CP021260.1\|WP_027229041.1\|3198533_3200381_+\|isocitrate/isopropylmalate-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223549
NZ_CP021260.1\|WP_062726425.1\|3220362_3220845_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|376771
NZ_CP021260.1\|WP_062726426.1\|3220973_3222455_-\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	unknown	unknown	gnl\|CDD\|182554
NZ_CP021260.1\|WP_027229042.1\|3197839_3198547_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_027222834.1\|3205852_3206308_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_062726453.1\|3218932_3220363_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|236692
NZ_CP021260.1\|WP_027229037.1\|3205284_3205740_-\|type-IV-secretion-protein-IcmV	unknown	unknown	unknown
NZ_CP021260.1\|WP_062726420.1\|3213169_3213970_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP021260.1\|WP_062726422.1\|3215042_3216068_-\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP021260.1\|WP_027229034.1\|3209717_3212261_+\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_CP021260.1\|WP_080463997.1\|3214084_3214942_-\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|368580
NZ_CP021260.1\|WP_027229039.1\|3201362_3202079_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|366780
NZ_CP021260.1\|WP_062726418.1\|3206307_3207711_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99920
NZ_CP021260.1\|WP_062726416.1\|3200380_3201241_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021260.1\|WP_062726424.1\|3217211_3218942_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NZ_CP021260.1\|WP_027229029.1\|3216060_3216255_-\|zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|226826

Protein	Function_ID	Function_description	E-value
NZ_CP021260.1\|WP_062726417.1\|3202186_3205288_-\|type-IVB-secretion-system-protein-DotA	gnl\|CDD\|275142	TIGR04346, DotA_TraY, conjugal transfer/type IV secretion protein DotA/TraY. Members of this protein family include transfer protein TraY of IncI1 plasmid R64 and DotA (defect in organelle trafficking A) of Legionella pneumophila.	3.95489e-42
NZ_CP021260.1\|WP_027229023.1\|3222585_3222981_-\|ClpXP-protease-specificity-enhancing-factor	gnl\|CDD\|236987	PRK11798, PRK11798, ClpXP protease specificity-enhancing factor; Provisional.	1.45551e-70
NZ_CP021260.1\|WP_027229041.1\|3198533_3200381_+\|isocitrate/isopropylmalate-dehydrogenase-family-protein	gnl\|CDD\|223549	COG0473, LeuB, Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism].	3.16749e-109
NZ_CP021260.1\|WP_062726425.1\|3220362_3220845_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	8.47723e-52
NZ_CP021260.1\|WP_062726426.1\|3220973_3222455_-\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	gnl\|CDD\|182554	PRK10565, PRK10565, putative carbohydrate kinase; Provisional.	9.95905e-143
NZ_CP021260.1\|WP_062726453.1\|3218932_3220363_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|236692	PRK10431, PRK10431, N-acetylmuramoyl-l-alanine amidase II; Provisional.	1.87048e-73
NZ_CP021260.1\|WP_062726420.1\|3213169_3213970_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.81134e-21
NZ_CP021260.1\|WP_062726422.1\|3215042_3216068_-\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.15153e-63
NZ_CP021260.1\|WP_027229034.1\|3209717_3212261_+\|cation-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	9.07761e-136
NZ_CP021260.1\|WP_062726418.1\|3206307_3207711_+\|hypothetical-protein	gnl\|CDD\|99920	cd05537, POLBc_Pol_II, DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as repair of DNA damaged by UV irradiation or oxidation has been proven by genetic studies. DNA polymerase III is the main enzyme responsible for replication of the bacterial chromosome; however, In vivo studies have also shown that Pol II is able to participate in chromosomal DNA replication with larger role in lagging-strand replication.	0.00529714
NZ_CP021260.1\|WP_027229039.1\|3201362_3202079_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	6.11327e-40
NZ_CP021260.1\|WP_080463997.1\|3214084_3214942_-\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	9.12098e-38
NZ_CP021260.1\|WP_062726423.1\|3216277_3217219_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	2.05443e-155
NZ_CP021260.1\|WP_062726424.1\|3217211_3218942_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	5.46299e-171
NZ_CP021260.1\|WP_027229029.1\|3216060_3216255_-\|zinc-finger-domain-containing-protein	gnl\|CDD\|226826	COG4391, COG4391, Uncharacterized protein conserved in bacteria [Function unknown].	1.13033e-13

>NZ_CP021260.1|WP_027229034.1|3209717_3212261_+|cation-translocating-P-type-ATPase
MSKPYFFYVSGMNCTSCSNAIESFLRNSNLIKVNTFHADMSTPDPKKIVISLSEEKENEHESNWNTIKKLIDETGFTCENYEFPPVKEQNSATPLEKTQSTPQQEASKLSGILNSAKKIITSHWLLGGLGCITGVSLMILTMALGGLPLAVMIPLAGFSILLTIALGAQSYYEAWKKFIQSRTLTMDTLFSISTISVLAVSVTSFFVPWLPMMFEAGLLIYGFRHIGIAIEDTIKEKISSAKFQDRAPQKVRLYRQPDFKSARIEEVQPNDIIQVKPGELIPLDSVCEQDTLIYPTIITGAIIPRQFRSGDKVLAGMRLANDAKPLTLRVLKTVKDSYLARLDESIAQSVLEKAPIEVKTGQLLTYFIPAIIAISILSGIIVGLISTPALAIQCAISVLVSACPCTLGLIIPLAVKTGIHKGAEHGVQFKNSRVLQLAEQIDAVIFDLNGTLTTGVPVVKEYAVLNNTDLSSEQFLSICNALEEQSKHPFGKAIQSFTQGINKQKFNIANLDHSNHSGISAEINGTQYTIGSKTLMQEIGISTSSIESQMNLVAGDSLVFLAKNKQLLGYLVITDPLRKDAKQTVEALIKMGKEVHLCTGADEKTAYRYAQALGIKKVHANCVATTINTEDKSKPIYIKSLQNQGLKVAMVGDAANDANAIAASDFGIAVLSQDSDEITQQHASAIIQSGTLLPIANAFAISKQTVNNIKQNLLISLGYNLTAVLIAGGLLVAAGFVLNPAVGVALMVTQACFVLLNVYRFKEQPLQHLQDTPQKKAEPATSSYEAMKKHTLNYHTDPTVNHKLSIQAEKQPVHKNKSPSFWNDYFPELFEEEKDTSTEHLMNNSLG
>NZ_CP021260.1|WP_062726419.1|3207717_3209358_-|hypothetical-protein
MSSLLSRRKTMLVLLIAIYCAYDLIVAVYTAWDFTTDDAYISWYYARQLVSGKGLFWHVTLPPVEGYSNFLWLMIAALVIKLQLPLVSSMKVISCCSLGLALLFLYRLARLFCSPLLSILPVFLFSHYTGVTWWAVSGLETLFYCALSLALIWQCTLAFGYQTVGDRPWPNRLSLYSTNHWVITNILLLLLCLTRFEGIIWIVPLTVFIGCQYLKDQRGLIFKDHKRLFLWVSIAFVCFILPYLVYFIWRLIYFGHWIPNSYRCKALAYGQLLVVDFDYFLFITPLLVLSVPYLLSANKDCRHVLLWLPSVLYSLLLWKANPVVTYGLRLFLSPFALFSILPVLGLSQLIQYFKFFRWDPEYPIVVLMLFITWFFVPGNDLNHLSKTVAEYNERTQNRMHIADLLNRKAKKGDSVLLDDCGIIPFFSREDIRFIDAQCLNNSDLTQKPFKNDLSLYANYLNSTVKPDWVITNYYPMESRGDYLTDLLDEQHFFKNYHLVSTLSSGFYLNQNQSQGKKMIDFVYQIFKRANKPGYNEPLELESQEPK
>NZ_CP021260.1|WP_062726418.1|3206307_3207711_+|hypothetical-protein
MKVLPKLALANLFYFTTLSVFAQQGYDPSGQQTSTNTSNLVTYLTNLGKYLGYDITQSNKAPNPPYSQLFNSNVAQLIQNYAYNTFLGAIPVDAMSQSLMNFVTNNVQGNSLINNLANNTFKYQNFSSPSSGADGKITANGLIDQSTTSAQAPTPSGIFSALQTPTSGTYLNDPVSQAVFNILGTPDYSFCMDNEQKSWLPNCNLMYQNLVMQNVIGTIPPAQTSGSTPAFYSYKYNQPLISQLNSNSLIAPLLMDTSASQSGQDSGLTAKSQAQQALNFIRYASAQVTPPSLPKLSAYSELWNQATAKPNSAGYNEVQQKQAAATLSSYFNNLRVYAAQTSVGVSNLYYILSKRLPQNMSGDQNNPNVTSQALNEFNMATRRLFDPTASNTPGQPNQQWIKQINDASPATVQKEIAVLLAEINYQMYLDRQIQERILLTNSIMLLQNLKAAQPTADFSSQGSPSEQ
>NZ_CP021260.1|WP_027222834.1|3205852_3206308_+|hypothetical-protein
MPDLSHEAAAKYWFEYLDPMIYRVITFMESVENWTLDGNPELEEAMKQLGQELDDIEKIDLGLLAEEDKFIRIVGNIKSGRGLRLLQAIDTVHPGSASRVLIHAEETSLSSNDPAGFFLKRNIVFERLRLLSRVFCQYRLKLVLRALEGDE
>NZ_CP021260.1|WP_027229037.1|3205284_3205740_-|type-IV-secretion-protein-IcmV
MKKKSGSRIVRVFTRIINVRKWFDWDRMKSLTLYLVNGIKRLFIPQEPTHVESFDEAARKLKLSEADLVIKQKALFRLSIIMVIAAFMILIYTGYQFLYGSWKATIISLVVVMIALVLAFRYHFWYYQIKQRKLGCTVKEWYRQGLLGEKE
>NZ_CP021260.1|WP_062726417.1|3202186_3205288_-|type-IVB-secretion-system-protein-DotA
MNKLAITVLLCFFPALALAENGALSFAPPASDLSVVFLGNLFGVVDGVLHGTGSQIMGNMFAVFNSAVLALGGIIIMYTLMVSTMNTAHEGQMLGQKWSSIWIPLRSTFGLALLIPKASGYCMMQVFFMWVIVQGVGAADKIWEAALSYLNRGGVIIQAQADPTKSLKAAGSSSSGVAKGALTILGGQICMLGLQKQLQAQRDLYLSQSKSPPCGGNPTPEMNTFCRTAIPDFISTVNFVKKQNDDTPKDLTANQPASFELDMPNFDKSSPFYFLNGICGTVKWNNISALNSTTQSNNKGLVTVGGAGSNSSMGANSLNITSSQLQTARLSRAIAIQQMYVTLSTVAQVMVNNDPAFSTTTSTGSSKNDFSPIAKQQFGVPYKASGEVCTEYQQVCQTWGSVPSSTGSTTGVLFNGTEFLGAINDYNGIMMPTLNLIRQATSKEFDKKSRDFIAEANAKGWIMAGSYFFDLVKLNGSATEFADQFDTGTGLDKSSFDPTQLTKPFGKTCQDPYALLCTWFQNKNDKLVQIQSLIDGVPALGQDGVKQPDLSDNPQRQSVSGPLSSTVYGFVNNSMMIQLPGQPGIKPLTFANLINFKVDTSLYYMKHQDFDCGRVKILFFSFCLGRMMGDLFYNYVFRYVYNFFLAIFGEMINSIVMAFLMIPLQGMKDIFIVGVQTLTQPGVNPIVALANMGTMYINFSGTLWLTLLNMAVVSSLIPLFGIFIFALIMMAMPLLMAWIGTMVSIGFVTAYYIPVLPYMIFTFGSFAWLIAVIEAMVAAPIVALGVTHPEGNEAFGKGEFAIMILVNVFLRPSLMIIGYIAAIALSYVGVWILNAGFDHAISYIQSDQGKDTSGEGWGGFKTDTSQWDNFKDKLTGDYQSTALEGGYTGWAGVYAFFFSILIYTSMYLIIVQKAFTLIAHLPDKVLRWIGGSPESFGQETMQWGEEAKGKVQEAGKETYGAEKAIGDKLGAKGQSMLGNLGPQAKKVSENAGDVSGKGKNSGGSQTGPSSKPDTGQQLGGSDSGTPTSTPPPE
>NZ_CP021260.1|WP_027229039.1|3201362_3202079_-|dienelactone-hydrolase-family-protein
MLVTEEVEYNDGDTVCKGFIAYQQSVSKPLPCVMVAHDWGGRGEGACSKAIQLAGMGYIGFAIDMYGNAKLGKDKAEKRALMTPFMQNRGKLIARINAAFNKVVQLPGVDSEKVAAIGYCFGGLCVLDLIRSGAPLKGGVSFHGVLSPLDGESTKPLNAKVLILHGYDDPLVPIEQVNQFAMEMTARKVDWQVHVYGQTAHSFTDPNANDDEMGLHYNKLADQRSWQSTQLFLQDLFA
>NZ_CP021260.1|WP_062726416.1|3200380_3201241_+|hypothetical-protein
MLSLKKLKFIDIHYHATPDLYIRRRNAIEAGRLYHSLYGAVVLKSHIGSTGVQATIGQEMGLPVFPSVVLNHINGGINYRAIIRALSEYQPLFSGKMIVDFPTITGRKFQSKLSRKLTHDNLKQYTQQVETLFGSKQQLRKEVIDILKMARDYPIVLTSGHASRDEIYRLIDACNQYDVPSLLLSQPSNPLTGLKFPELNELLKNEWLWVEQTALTFILGHQDKQDFSQVLTHLPRVIYSSDLGQPSQMDIPEWLHFSKRIFHELDLSEKRKEELLLSNAIALLSL
>NZ_CP021260.1|WP_027229041.1|3198533_3200381_+|isocitrate/isopropylmalate-dehydrogenase-family-protein
MKSTDPIKIAVLPGDGIGIEVTEATLPVFEVLDVPATLSYGDIGWEFWKKEGTAIPSRTWQLIASSDTILLGAITSKPQREAKQELSKALRKSNPYYVSPVIQLRQGLDLFANVRPCFSIDDQSKPFNFCIIRENSEGLYCGFDYFPLPKAIHNLLAESQHWQTIPADEASCALRLQSKPGLTRLFDFAFNHAIQIGMHRVTLADKPNVLRESGEFARKIFENTAQRYPKIQADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRMKKNCANPSAMFLTISMLLNHFGYPDRAKIIVNAVMQVIQEKRFITYDLGGHATTTDMANAVIEHCARLMASCLSTECNPVPKQNLLESDTTSHLLQQLMNCNSAEISDALDACGIEGGLLNIKPLSPGMKMVGPAYTIQYLPREKKEAAFHNAANYIDKVPGHSVIVIDNNGQTDCTVWGDLLTHTALRNNIIGTVVHGAVRDVESIRSTNYPVFCAGIYMRSGKNRVYKANEQCPLFINGVTINPGDIIFADDNGVLVIPNDLLQEVVNKALVIRLTEERIKTAIASGSTLEQAREDYYYEQPWLGINKKREP
>NZ_CP021260.1|WP_027229042.1|3197839_3198547_+|hypothetical-protein
MAKKRLLIIGPVSTQSSSLRHLSQNLSFLNPYYSIECLDPLVTLQECPDEEYYGIWQNQLKQLIKIYDAFVGFSFGGVILQQCFSILSGEKKQIILFSTPTFADSILREKLETVISLCSQNKLEEGLSSLYQAVYAPHSIPDASLQYLNRELAIKRLIFGLTKVLKTNCVSILNHCNVNHLHLIGEKSQLVNTNNVIKPSCGQLIVVPEASMRVLESNPTFCKEIIFKALNHEIH
>NZ_CP021260.1|WP_062726420.1|3213169_3213970_-|class-I-SAM-dependent-methyltransferase
MDNESLLAILNNWSAINYAKGNYILREISSKFLSKISIHSHDYLLDAGCGDGSFTQIVASLAPDGYILGLDRSKTMIDYANKHYRSINIRFDIGDIQEPIIYGPFDNIVSFWCLHWTDLEKSLSNLYHVLKPGGKIYAIFSSGKQSTLFEVLNSLQFQNRYPDIAKNVAQSKMMRENYSVRCRKALDNLPFKSISFAVEHCQVELPDLESFENFIHGAPLFKDLPSKIYQDIVSSMVLFFDEYCQKKYGGKWVYEATPYFLTISRK
>NZ_CP021260.1|WP_080463997.1|3214084_3214942_-|phytanoyl-CoA-dioxygenase-family-protein
MILIFEEHRMQLSSEQCDFFFTNGYLVINDFFAESVCDLLKQRIETLLENNQTEIPKTIFSTQTNEHAKKQYFLDSGDKIHYFFEPGAFDESGDCIRTFKQSVNKIGHALHELDPVFRQYSRDERIKKIAHQLGLATLGLAQSMYIFKQPGIGAEVLCHQDSTYIFGENSDALGFWFAIEDATLENGCLEVIPSPCTTPLKQRMFRRENEIYFEYYDSTPWPEEKSVPLPVKKGALIILHGRVPHKSQANFSDQSRHAYTLHLVDISLPYPENNWLQWPNGIPCL
>NZ_CP021260.1|WP_062726422.1|3215042_3216068_-|glycosyltransferase-family-9-protein
MIKSICIVRLSALGDVLMLVPLIRTLQNKLPNAQLTWVISKPAFYLVEGMEGVEFIVIDKPKTPADYWRFRKQMLPRQFDVLLAPQASFRTNWLIPFIKAKRKIGYDSHRANDGHRLFVKESITPGLEHTLEGFLKFAEPLGVTEKIIRWDLPITKADYEWVQNHFPEQEGPILVVNPAASKPERSWLAERYIEVLKQAQVKWNVKVVLTGGPGDHDKSLAEQIAKEIPAINLVGKTKPKQLLAVISKAKAVLCPDTGPSHMAAAVGTPVVALHAVTNPCISGPYTFQHLVVNRYSQAVQAVLGVSPEKNIWGTQVHGYDAMKLITVDDVMDKLTEIFKGL
>NZ_CP021260.1|WP_027229029.1|3216060_3216255_-|zinc-finger-domain-containing-protein
MRKTTKELASAKKNYVVHRHQLPLSCPTDEMELWNAHPKVYLPIEKTGVEVCPYCGSRFVLQND
>NZ_CP021260.1|WP_062726423.1|3216277_3217219_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MNKVVFCLMGPTASGKTGLACELVTHFPFEIISVDSAMIYRDMNIGTAKPSIHELQRAPHYLIDIKDPVESYSAAQFCIDALSLCEEIIKRGNIPLLVGGTMMYFNALQKGLATLPEADEAVRKRLEEEALSQGWDFLYQRLSQLDPVTAARIHAHDTQRIQRALEVYYLTGSTLSAYLAEPLEQPDYYFVNLALFPEQRSWLHERIAQRFDAMLSEGFIEEVQQLQEKWPIQISMPSMRCVGYRQIFEYLEGHYDYETMREKGIAATRQLAKRQLTWLRHWQGALFYDAQNEGFSAYIIAKIREILDNTVSN
>NZ_CP021260.1|WP_062726424.1|3217211_3218942_-|DNA-mismatch-repair-endonuclease-MutL
MVLRIHQLPPAIANQIAAGEVIERPASVVKELLENSLDAGASVISVEVNYGGLLQITVSDNGSGIVKDDLPLAVAAHATSKIRTLNDLYSIDSMGFRGEALASIASVAKVTIISKPEGQDNAMMLQVEGERRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFALSAPQIALTLKHNKKLIFSLPPALSEQAKAIRMSRILGNTFMREAIFLDVEHSGMRLYGWISNQRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPVCLLYFTLHGSEVDVNVHPTKHEVRFQQPRLVHDFFTSQLTKALHSNLTDLDTREYAYAIASCNERQNAIAEPAHSRNHIETHGGSNDLLPNRSGNSFSSSITSKGYKKNSAVCHLETESQWIVLNERFILVFLKQQPYLVDLVALFQEWTEKQLMKKALPLESRPLLISIRYPLPKQWMHRLDHIKHELARVGIRIEYPIADELLIRSIPLSAPYLDVRLFFNFLCELDFFHTEQLIALISRSQMFDPKQLTVEERIEMNQLLQELSLKEEKHNAYKALTIDDCRMLLHE
>NZ_CP021260.1|WP_062726453.1|3218932_3220363_-|N-acetylmuramoyl-L-alanine-amidase
MMMRAWVLSLLLYIPSSFAVFSAQLKNVSVSQQSTVTSLYLTIQGSFTHKLFTLSHPNRVVLDLSDTNLAVNLSQLSLINSLIQQVRSGSPSKSTLRLVMDVKQPVKVRSSSWKPKGEFNGIRIDLVNDTPLVINNRSQLSTSVKTIKGPVQQNQPKISSQPSEPRITAHKTPIQAPHNPSKKPLRDVVVVLDAGHGGKDPGARGPRRSNEKDVVLAITLKLKRLIDRQPGMRAVLTRSGDYYVGLRQRLDIARKYNGDVFISIHADAFNNPHSNGASVFALSQRGATSEAARWLAEKENYSELGGVNLGELDDSNGVVRSVLIDLSQTATINAGLEMGGKVLGQLDNFTNLHNNKVEQARFVVLKSPDIPSILVETGFISNPREERNLTNPAYQERLSQAIFQGLKNYFWDHPPHGTRIEAMISPNFHIVKKGETLPAIAARYRVSVSALQSINRLQARARLMPGQKLVIPGTWS
>NZ_CP021260.1|WP_062726425.1|3220362_3220845_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MTIEDNDNFITLDLVSEQESKRFAEKLAFCITAPLVITLSGDIGAGKTTIIRAMLKSLGVISAIKSPTFSLVESYSCSEFHVHHFDLYRIHQEEELDYLGFRDYFSNQSVCCIEWPEHAGKTLPPVDIQFNLIIRGTGRLMQIAALSDAGKRILACLAGE
>NZ_CP021260.1|WP_062726426.1|3220973_3222455_-|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase
MNKLENALYRCDQIRACEQQALTLYQKDENALMALAGAEAFSFLQKLYPHVRHIAVFCGAGNNAGDGYVLARLAHEQGFSVTVYQCKSLEDLPSAARNAARLALASGVNCQSADEPLDGEAELIVDALLGIGLQGPVHGVIANAIHQINASGLPVLSIDIPSGLNADTGLVENICVNATATITFIGLKTGMYTLDGPDYCGVIHCSDLNLDACKTKISRFASLLRDSTLPLPLAARKKNSHKGDHGHVLVIGGGQGMPGAVSLAAKAALRTGVGVATVATWPDYAKGTLPLIPEAMVWGIKTAEELMPLLAKATVCVIGPGLGDSDWAKTLFLRAMTTQLPMIIDASALRLLSQHPQMDDNWILTPHPGEAASLLSCTVKDVQMDRYHAASAIQKQYGGVVVLKGVGTVIQTTEKNIFVCPKGNPGMATAGMGDILSGIIAAFCAQGFSLSDAAKLGVWVHAVAGDKVAERSGEVGLLASDLLDEIPSILNCI
>NZ_CP021260.1|WP_027229023.1|3222585_3222981_-|ClpXP-protease-specificity-enhancing-factor
MAMTSNRPYLIRAFYDWIVDNDLTPYILVDASNPNVQVPREHVQHDRIVLNISPSATRGLLLENDRIVFTARFSGQTEQIFVAPNAVLEIYAKENGRGIAFSVDEDDEPPPKTSSSSDSATKNKPSLKLVK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_AP019741	Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788 strain NBRC 102413 plasmid pARA1, complete sequence	181525-181555	7	0.774
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	CP032137	Acinetobacter haemolyticus strain sz1652 plasmid unnamed2, complete sequence	12732-12762	7	0.774
NZ_CP021260_1	1.4\|189804\|37\|NZ_CP021260\|CRISPRCasFinder,CRT,PILER-CR	189804-189840	37	NZ_CP039965	Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence	1503160-1503196	8	0.784
NZ_CP021260_2	2.4\|225027\|37\|NZ_CP021260\|CRISPRCasFinder,CRT,PILER-CR	225027-225063	37	NZ_CP039965	Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence	1503160-1503196	8	0.784
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_CP023033	Acinetobacter baumannii strain 7847 plasmid pAba7847b, complete sequence	13176-13206	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_CP015366	Acinetobacter baumannii strain 3207 plasmid pAba3207b, complete sequence	13176-13206	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	CP046596	Acinetobacter indicus strain FS42-2 plasmid pFS42-2-1, complete sequence	85188-85218	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_CP038264	Acinetobacter baumannii strain LEV1449/17Ec plasmid pEC_gr6, complete sequence	10129-10159	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_CP033245	Acinetobacter baumannii strain 7835 plasmid pAba7835b, complete sequence	13175-13205	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_CP023028	Acinetobacter baumannii strain 10042 plasmid pAba10042b, complete sequence	45800-45830	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_CP042365	Acinetobacter pittii strain C54 plasmid pC54_001, complete sequence	58146-58176	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	NZ_KX118105	Acinetobacter baumannii strain IHIT7853 plasmid IHIT7853-OXA-23, complete sequence	41991-42021	8	0.742
NZ_CP021260_3	3.1\|3212666\|31\|NZ_CP021260\|CRISPRCasFinder	3212666-3212696	31	HG796278	Uncultured bacterium plasmid pRGI00192	2532-2562	9	0.71

1. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_AP019741 (Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788 strain NBRC 102413 plasmid pARA1, complete sequence) position: , mismatch: 7, identity: 0.774

ttctattattatatctaactattgcaaaatt	CRISPR spacer
ttattgcataatatttaactattgcaaaata	Protospacer
** *  .** ****.***************

2. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to CP032137 (Acinetobacter haemolyticus strain sz1652 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.774

ttctattattatatctaactattgcaaaatt	CRISPR spacer
ttattgcataatatttaactattgcaaaata	Protospacer
** *  .** ****.***************

3. spacer 1.4|189804|37|NZ_CP021260|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039965 (Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.784

tcagggag---gggcagtgaaaattatggcaaacaagaac	CRISPR spacer
---aggagcccgggcagtgaaaattacggcaaacaagggg	Protospacer
   .****   ***************.**********..

4. spacer 2.4|225027|37|NZ_CP021260|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP039965 (Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.784

tcagggag---gggcagtgaaaattatggcaaacaagaac	CRISPR spacer
---aggagcccgggcagtgaaaattacggcaaacaagggg	Protospacer
   .****   ***************.**********..

5. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_CP023033 (Acinetobacter baumannii strain 7847 plasmid pAba7847b, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

6. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_CP015366 (Acinetobacter baumannii strain 3207 plasmid pAba3207b, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

7. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to CP046596 (Acinetobacter indicus strain FS42-2 plasmid pFS42-2-1, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

8. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_CP038264 (Acinetobacter baumannii strain LEV1449/17Ec plasmid pEC_gr6, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

9. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_CP033245 (Acinetobacter baumannii strain 7835 plasmid pAba7835b, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

10. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_CP023028 (Acinetobacter baumannii strain 10042 plasmid pAba10042b, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

11. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_CP042365 (Acinetobacter pittii strain C54 plasmid pC54_001, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

12. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to NZ_KX118105 (Acinetobacter baumannii strain IHIT7853 plasmid IHIT7853-OXA-23, complete sequence) position: , mismatch: 8, identity: 0.742

ttctattattatatctaactattgcaaaatt	CRISPR spacer
taattgcataatatttaactattgcaaaata	Protospacer
*  *  .** ****.***************

13. spacer 3.1|3212666|31|NZ_CP021260|CRISPRCasFinder matches to HG796278 (Uncultured bacterium plasmid pRGI00192) position: , mismatch: 9, identity: 0.71

ttctattattatatctaactattgcaaaatt	CRISPR spacer
ccgcatttttatatccaactattgcaataaa	Protospacer
.. .*** *******.*********** *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1010698 : 1017537

Acinetobacter_phage(42.86%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062727111.1\|1010698_1011475_-	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	1.1e-57	48.6
WP_062727110.1\|1011467_1012502_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	9.3e-76	47.6
WP_062727109.1\|1012479_1013058_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	3.9e-55	52.6
WP_027221199.1\|1013091_1013817_-	LPS export ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.1e-18	25.1
WP_010946573.1\|1013813_1014323_-	lipopolysaccharide transport periplasmic protein LptA	NA	NA	NA	NA
WP_010946574.1\|1014303_1014873_-	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
WP_011213328.1\|1014869_1015397_-	3-deoxy-manno-octulosonate-8-phosphatase KdsC	A0A140XBD6	Dickeya_phage	1.4e-27	47.7
WP_010946576.1\|1015410_1016373_-	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	4.2e-38	34.1
WP_010946577.1\|1016739_1017537_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.3e-21	33.8

DBSCAN-SWA_2

1332558 : 1338496

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062727573.1\|1332558_1333632_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.5e-28	27.0
WP_062727574.1\|1333616_1334231_+	riboflavin synthase	A0A2I2L4R9	Orpheovirus	4.6e-22	38.4
WP_027227759.1\|1334227_1335436_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.9e-98	48.7
WP_062727575.1\|1335443_1335911_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.9e-23	50.9
WP_028378484.1\|1336037_1337675_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	3.2e-155	52.5
WP_062727576.1\|1337671_1338496_+	3-deoxy-8-phosphooctulonate synthase	E3T537	Cafeteria_roenbergensis_virus	2.7e-54	44.3

DBSCAN-SWA_3

2275215 : 2285332

Bacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062726361.1\|2275215_2276898_-	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	6.1e-16	30.4
WP_062726360.1\|2277031_2278039_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_062726359.1\|2278163_2279489_-	adenosylhomocysteinase	S4VPF6	Pandoravirus	2.8e-48	31.7
WP_062726358.1\|2279507_2280656_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.3e-126	58.2
WP_062726357.1\|2280859_2281972_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	7.2e-50	34.7
WP_027229222.1\|2282070_2283210_-	molecular chaperone DnaJ	A0A1V0SBY2	Catovirus	1.6e-23	26.7
WP_062726356.1\|2283397_2285332_-	molecular chaperone DnaK	G8DDB7	Micromonas_pusilla_virus	1.3e-147	49.6

DBSCAN-SWA_4

2784541 : 2836131

Burkholderia_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072356411.1\|2784541_2784622_-\|transposase	transposase	NA	NA	NA	NA
WP_014842352.1\|2785130_2785982_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_027265135.1\|2785978_2786587_-	AbiEi antitoxin N-terminal domain-containing protein	NA	NA	NA	NA
WP_014842354.1\|2786829_2787093_+	hypothetical protein	NA	NA	NA	NA
WP_014842355.1\|2787092_2787743_+	DUF3800 domain-containing protein	NA	NA	NA	NA
WP_014842356.1\|2787891_2789979_+	hypothetical protein	NA	NA	NA	NA
WP_014842357.1\|2789980_2790361_-	hypothetical protein	NA	NA	NA	NA
WP_014842358.1\|2790580_2791141_-	recombinase family protein	A0A286S1P7	Klebsiella_phage	1.9e-54	57.7
WP_014842359.1\|2791151_2791469_-	DUF2442 domain-containing protein	NA	NA	NA	NA
WP_014842360.1\|2791423_2791684_-	DUF4160 domain-containing protein	NA	NA	NA	NA
WP_014842361.1\|2791854_2794899_+\|transposase	Tn3 family transposase	NA	NA	NA	NA
WP_014842362.1\|2795569_2796718_+	outer membrane beta-barrel protein	NA	NA	NA	NA
WP_014842363.1\|2796747_2797866_+	DUF3494 domain-containing protein	NA	NA	NA	NA
WP_154080660.1\|2798169_2798328_+	hypothetical protein	NA	NA	NA	NA
WP_027265134.1\|2798375_2798717_+	helix-turn-helix domain-containing protein	A0A218MNC9	uncultured_virus	4.5e-11	39.0
WP_027265133.1\|2798733_2799225_+\|transposase	IS630 family transposase	A0A1V0SCG6	Indivirus	1.3e-11	25.8
WP_014842364.1\|2799473_2799725_-	hypothetical protein	NA	NA	NA	NA
WP_014842365.1\|2799805_2800000_-	CsbD family protein	NA	NA	NA	NA
WP_014842366.1\|2800132_2800486_-	PRC-barrel domain-containing protein	NA	NA	NA	NA
WP_014842368.1\|2801342_2801846_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014842369.1\|2801848_2803030_-	acetylornithine deacetylase	NA	NA	NA	NA
WP_065211439.1\|2803334_2803502_+	DUF3309 domain-containing protein	NA	NA	NA	NA
WP_014842370.1\|2803626_2804832_+	fatty acid desaturase	NA	NA	NA	NA
WP_027265132.1\|2805038_2805722_-	anion permease	NA	NA	NA	NA
WP_050598106.1\|2806137_2807106_+	TIGR00341 family protein	NA	NA	NA	NA
WP_161499076.1\|2807376_2808384_+	fatty acid desaturase	NA	NA	NA	NA
WP_014842377.1\|2808678_2809014_+	hypothetical protein	NA	NA	NA	NA
WP_027265129.1\|2809183_2810515_+	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	5.1e-58	35.1
WP_106174730.1\|2811466_2812642_-\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	8.3e-12	20.5
WP_062728145.1\|2812949_2813984_+	hypothetical protein	NA	NA	NA	NA
WP_062728144.1\|2814166_2815018_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_062728146.1\|2815014_2815623_-	AbiEi antitoxin N-terminal domain-containing protein	NA	NA	NA	NA
WP_106174732.1\|2816015_2817191_-\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	8.3e-12	20.5
WP_152027454.1\|2817420_2818134_+	hypothetical protein	NA	NA	NA	NA
WP_062728338.1\|2818438_2818750_-	cupin	NA	NA	NA	NA
WP_062740169.1\|2818765_2820058_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_062727163.1\|2820092_2821301_-	hypothetical protein	NA	NA	NA	NA
WP_021437177.1\|2821321_2821582_-	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_062740165.1\|2821584_2822979_-	iron-containing redox enzyme family protein	NA	NA	NA	NA
WP_061692649.1\|2822983_2823619_-	flavin reductase family protein	NA	NA	NA	NA
WP_062740163.1\|2823787_2825134_+	hypothetical protein	NA	NA	NA	NA
WP_080464247.1\|2825123_2825879_-	hypothetical protein	NA	NA	NA	NA
WP_061692647.1\|2825881_2826079_-	hypothetical protein	NA	NA	NA	NA
WP_062740162.1\|2826098_2827325_-	MFS transporter	NA	NA	NA	NA
WP_062728057.1\|2827903_2828584_+	hydrolase	NA	NA	NA	NA
WP_062728058.1\|2828654_2830496_+	amidohydrolase	NA	NA	NA	NA
WP_080464248.1\|2830755_2831664_-	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_192875845.1\|2831766_2832117_+	hypothetical protein	NA	NA	NA	NA
WP_062728061.1\|2832574_2833732_+	hypothetical protein	NA	NA	NA	NA
WP_106174734.1\|2833998_2834298_-	hypothetical protein	NA	NA	NA	NA
WP_192875842.1\|2834297_2834594_-	hypothetical protein	NA	NA	NA	NA
WP_062727321.1\|2834865_2836131_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	3.5e-16	21.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021260

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection