CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP021269	Legionella pneumophila subsp. pneumophila strain Bellingham 1 (D-7473) chromosome, complete genome	2 crisprs	cas3,csa3,DEDDh,DinG,PD-DExK,WYL,RT	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP021269_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021269_1

2326957-2327047

Unclear

Consensus_repeat	Method
GGCTCTTCCCCAAATCCGGGGGCA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP021269_1

>merge|NZ_CP021269|1|2326957-2327047|CRISPRCasFinder
GGCTCTTCCCCAAATCCGGGGGCACTAATCAAGAACACAAAACTTTAACCCTTAACCTATAGTTTTCGGCTCTTCCCCAAATCCGGGGGCA

>NZ_CP021269|1|1|2326957-2327047|CRISPRCasFinder
GGCTCTTCCCCAAATCCGGGGGCA	CTAATCAAGAACACAAAACTTTAACCCTTAACCTATAGTTTTC
GGCTCTTCCCCAAATCCGGGGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021269.1\|WP_010947832.1\|2333427_2333637_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP021269.1\|WP_016356971.1\|2323889_2324396_+\|antirestriction-protein-ArdA	unknown	unknown	gnl\|CDD\|377800
NZ_CP021269.1\|WP_014326980.1\|2325649_2326468_-\|Dam-family-site-specific-DNA-(adenine-N6)-methyltransferase	unknown	unknown	gnl\|CDD\|182825
NZ_CP021269.1\|WP_027224832.1\|2327053_2328229_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP021269.1\|WP_014844324.1\|2331393_2331690_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226194
NZ_CP021269.1\|WP_016356969.1\|2321535_2322339_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_025519966.1\|2319552_2319762_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_016356968.1\|2318982_2319468_+\|DUF1845-family-protein	unknown	unknown	gnl\|CDD\|378089
NZ_CP021269.1\|WP_064319116.1\|2328267_2329398_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP021269.1\|WP_014844326.1\|2333876_2335283_+\|ATP-dependent-RNA-helicase-DbpA	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236977
NZ_CP021269.1\|WP_014326976.1\|2323566_2323827_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_027224835.1\|2331149_2331404_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	unknown	unknown	gnl\|CDD\|274227
NZ_CP021269.1\|WP_014326978.1\|2324497_2325115_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_016356970.1\|2322331_2323231_+\|integrase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372340
NZ_CP021269.1\|WP_027224834.1\|2330235_2330802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_016356972.1\|2325147_2325639_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_027224833.1\|2329552_2330131_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_014844327.1\|2335439_2336351_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|226474
NZ_CP021269.1\|WP_076613127.1\|2336442_2336961_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP021269.1\|WP_014326973.1\|2319908_2320877_-\|DUF3644-domain-containing-protein	unknown	unknown	gnl\|CDD\|378842

Protein	Function_ID	Function_description	E-value
NZ_CP021269.1\|WP_010947832.1\|2333427_2333637_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	3.52513e-27
NZ_CP021269.1\|WP_016356971.1\|2323889_2324396_+\|antirestriction-protein-ArdA	gnl\|CDD\|377800	pfam07275, ArdA, Antirestriction protein (ArdA). This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.	6.53039e-40
NZ_CP021269.1\|WP_014326980.1\|2325649_2326468_-\|Dam-family-site-specific-DNA-(adenine-N6)-methyltransferase	gnl\|CDD\|182825	PRK10904, PRK10904, adenine-specific DNA-methyltransferase.	1.03134e-118
NZ_CP021269.1\|WP_027224832.1\|2327053_2328229_-\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	8.4756e-65
NZ_CP021269.1\|WP_014844326.1\|2333876_2335283_+\|ATP-dependent-RNA-helicase-DbpA	gnl\|CDD\|236977	PRK11776, PRK11776, ATP-dependent RNA helicase DbpA; Provisional.	0
NZ_CP021269.1\|WP_014326973.1\|2319908_2320877_-\|DUF3644-domain-containing-protein	gnl\|CDD\|378842	pfam12358, DUF3644, Protein of unknown function (DUF3644). This domain family is found in bacteria, and is typically between 65 and 80 amino acids in length.	2.39606e-26
NZ_CP021269.1\|WP_016356968.1\|2318982_2319468_+\|DUF1845-family-protein	gnl\|CDD\|378089	pfam08900, DUF1845, Domain of unknown function (DUF1845). This family of proteins are functionally uncharacterized.	0.000775231
NZ_CP021269.1\|WP_027224835.1\|2331149_2331404_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	gnl\|CDD\|274227	TIGR02606, Antitoxin_ParD, putative addiction module antidote protein, CC2985 family. This bacterial protein family has a very similar seed alignment to that of pfam03693 but is a more stringent model with higher cutoff scores. Proteins that score above the trusted cutoff to this model almost invariably are found adjacent to a ParE family protein (pfam05016), where ParE is the killing partner of an addiction module for plasmid stabilization. Members of this family, therefore, are putative addiction module antidote proteins. Some are encoded on plasmids or in prophage regions, but others appear chromosomal. A genome may contain several identical copies, such as the four in Magnetococcus sp. MC-1. This family is named for one member, CC2985 of Caulobacter crescentus CB15. [Cellular processes, Other, Mobile and extrachromosomal element functions, Plasmid functions].	1.27591e-15
NZ_CP021269.1\|WP_016356970.1\|2322331_2323231_+\|integrase-domain-containing-protein	gnl\|CDD\|372340	pfam12835, Integrase_1, Integrase. This is a family of DNA-binding prophage integrases found in Proteobacteria.	8.38322e-11
NZ_CP021269.1\|WP_014844324.1\|2331393_2331690_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	3.80144e-18
NZ_CP021269.1\|WP_014844327.1\|2335439_2336351_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|226474	COG3965, COG3965, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.15747e-100
NZ_CP021269.1\|WP_076613127.1\|2336442_2336961_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.73229e-05
NZ_CP021269.1\|WP_064319116.1\|2328267_2329398_-\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	2.31561e-49

>NZ_CP021269.1|WP_014326980.1|2325649_2326468_-|Dam-family-site-specific-DNA-(adenine-N6)-methyltransferase
MDSITRIRPFLKWAGGKFQIISKIRSSLPEGSRLIEPFLGSGSVFLNTNYEQFLLADINADLINLFQHLKVEKSDFIYFCKKFFNTDSNSQSVYLSLRSEFNSTKDSYLKSALFLYLNRHSFNGLIRYNSSGKFNTAFGDYKQPYFPENEMFTFIQKAEKAEFRCADYKVIMKEAVKGDVIYCDPPYAPLSASANFTKYHSTSFGLEDQRQLVELAKELAAKGVPVIISNHDTTFIQSLYQGSRIVSFDVQRNISCNGSARTRAREVLALFD
>NZ_CP021269.1|WP_016356972.1|2325147_2325639_-|hypothetical-protein
MKQGGSYANSSGGVLEGLVEFALTKKGFTVVRYKDWRLNPSSYSEELLLKNVPYEGLYKHASATEFVLMSKAYNLNTRIECKWQQVSGSVDEKLPYLFLNCSEKMVEPHIIILLDGGGAKPGAIEWLRDACEKFNLKEATTSKRKIDLMSMTEFVQWVNSVFK
>NZ_CP021269.1|WP_014326978.1|2324497_2325115_-|hypothetical-protein
MLEDLNAINSGMVEFGCSLLGKSLYDLTFAPMGGECVHPYAYSSLVQALEILMKAAIAEKHPLLIYEKIPKLTSKNDQLNEFFKKARSRSFLDLPDLLALTTNYQIEYNLLEIAWINRCKIIHIGHSFSLDYTYSGLELTFNVIDPFIYKFWNRSSIDETTSFDSETPIYLVEHCLDYNINFKMRKGQIDKDEDIFPRITEQHYY
>NZ_CP021269.1|WP_016356971.1|2323889_2324396_+|antirestriction-protein-ArdA
MDTPQIYVACLAAYNNGILHGEWIDATQDANTIYDEIHEMLAKSPIEDAEEFAIHDFEGFGGAQISEYDSINDVAELASFIMKHGELGAELFSYYSIEDAERMLEENYHGAYDNEVDFARALFDDCYSSTIPEDLLFYFDYEAFARDLFISDYLSVEADGQTHVFSNY
>NZ_CP021269.1|WP_014326976.1|2323566_2323827_+|hypothetical-protein
MDDSFFNHLGETSLMWWFSQFLEKIMENVSSTISRKEYVFFDLACCINEFHALHEELSAQDIEEIKRLSKKLHSLLEDQHPRLNLV
>NZ_CP021269.1|WP_016356970.1|2322331_2323231_+|integrase-domain-containing-protein
MSNTKLRSAKFSINELVKKAYNHSYASQSDMRHMLFRCVKDLHELGYKIGHIKGLKAKHIYVLVEHWKSEGKNTGTIKNYMAKLRKTACLLDNPMLIKPENGAYNIGQRSYVSSINKAIHHIDLSRCTDPYIRLSLEGQMLFGLRREESMKFTLSEAHHGDSLTIKPSWTKGGIGRTLNITNEAQRQWLTKVSQQVKTGESLIPSNRTYKQHLSHYEEQAKIMGVSKLHGLRHAYAQRRYRELTQLFDSKNKGMLCPFEGGKKFQDMNPIEKAMDRKARQMISLELGHSRISITRIYCG
>NZ_CP021269.1|WP_016356969.1|2321535_2322339_+|hypothetical-protein
MRKSQLRQQVDQYCKHNHTGSFRAKKHRHFVLHKMIRDLYHIGHVPSKWHAVTHDHMVRLVAHWQKEEIKPKTIMKYMTLIRRFFQSIDHTIDNISNQNLGIKCAQLRSKTILFPNNHLEILKNPIAKIVIEFQIYFGLTLSEAMRLNPAIHIQENSLWITRDIATNSHDRRIPVRNDKQAQANKTLQTLCKEESLILTFGYHSVRGAYSHAIKKIGLSSSRSYRCFYAKSMYPELCQILSPYLAKQTIMREMGLQSRRTLWSYLHE
>NZ_CP021269.1|WP_014326973.1|2319908_2320877_-|DUF3644-domain-containing-protein
MAKQRKRSVFSIKNELIKKSQEAALAAIQLYNNPLITFKSESFIVLMNIAWTYLLHAYFRKNNVEYRYYNSPKSRKLFIKTKHGAYKYWELEKCLNHESCPLEKAIKDNLLFLIGIRHEIEHQMTSKIDSFFSAKFQACCINYNSTLKNLFGNDYGLEKITPIALQLFSFGESQVDELIEKKELPKNLLDFISDYETDCDSLTDSRYSYRVFYMRINTNHENQADRAYRFIDEKSASGMAIDNILFKYKQYKKLTQNEVIDIIKKQGKNFDKTAHQNLWKRLWKDASTRNIQAKQYGELVVNNQWLWYQETWIPKILELLSE
>NZ_CP021269.1|WP_025519966.1|2319552_2319762_-|hypothetical-protein
MKKLIFILLCFPTMIFANPAQESKNIETFKQLCKNGKDVSMREHYCKLLEQQKKAEAIFKDFEKNKSST
>NZ_CP021269.1|WP_016356968.1|2318982_2319468_+|DUF1845-family-protein
MKAEITLNLRTREVYKLFERKISGDRLFIDVILHKMNIVIGQNRKPNPMALKMLSEMEQQLNSLTNAFSSEIRRFEELLAKKKEFKDKQINFVVQFHPKIIVCNPLSIKLAELIEVYDQLIATLKLLRLAGCFETDQAYFIHMKQKQKLTNQSLSKIILAE
>NZ_CP021269.1|WP_027224832.1|2327053_2328229_-|ISL3-family-transposase
MPKKDCILNLPGYSIKKVSGENPVYIEVSYRNVVRCIYCGNKKLRKKDSFIRRIRHESIGLRRSYLCIKAHKYYCSVCSRYFNQRFPGIGKYQRASESLRKQVFHYHSKGVSQKDLARDLKLGKSTVERWYHYGYELRYKKIATRSCPRVLGLDEHSFNRKVGYATTFCDLAKHKIFDVVEGRSEKDLEGYLNTLEGKEKVQVVCIDLSSSYRKLIRRYFPNAMIVADRFHVIRLLNQFCLQTYQQIDPEMKYQRGLLAALRTNPNNLSVKRLNKRERYLQQQPVIAALYNFKQRLHRLLMRKHRTAKQCTRLIPLFLKLVASLKESPFESLKTLGRTLYQWREEVVRMWRFTKNNGITEGFHRKMKLIQRRAYGFRNFENYRLRVRVLCG
>NZ_CP021269.1|WP_064319116.1|2328267_2329398_-|ISL3-family-transposase
MPKKDCILNLPGYSIKKVSGENPVYIEVSYRNVVRCIYCGNKKLRKKDSFIRRIRHESIGLRRSYLCIKAHKYYCSVCSRYFNQRFPGIGKYQRASESLRKQVFHYHSKGVSQKDLARDLKLGKSTVERWYHYGYELRYKKIATRSCPRVLGLDEHSFNRKVGYATTFCDLAKHKIFDVVEGRSEKDLEGYLNTLEGKEKVQVVCIDLSSSYRKLIRRYFPNAMIVADRFHVIRLLNQFCLQTYQQIDPEMKYQRGLLAALRTNPNNLSVKRLNKRERYLQQQPVIAALYNFKQRLHRLLMRKHRTAKQCTRLIPLFLKLVASLKESPFESLKTLGRTLYQWREEVVRMWRFTKNNGITEGFRLYPNKGGILIKLV
>NZ_CP021269.1|WP_027224833.1|2329552_2330131_+|hypothetical-protein
MVNITGGNINKKIYDEYLFYYQSRLPKDAHRHAPVLANVSVFLSNPSLITQALAVLEQEVKFLWDFENSTRTADKQLKLNQSIQFCRFMNLLWPVPNEELISNKTNNLLSKVLLYREQKHGFNFDENLSQRPVPTFVGFVDKKEADKVLEKNQLWSEENKLSPLFFHGKETHRLQLNLIMIAVELGLLDIGG
>NZ_CP021269.1|WP_027224834.1|2330235_2330802_+|hypothetical-protein
MNLRHPLILRKTPAIITDNMEHNSQYIYGMDPFYFHSYLMSIARKDYPYLAQCVTEKFCKSAFKLNQIENALGYKYGNDELRALGTNERDIMSTLERLAKAYNTNIHVITSEHILQYQQAKKEGKAFNEVTNSKKLEIRAGTIKSNGFTFKDTVGVVLFKKPYQGWQEYKKHKNSHSIMEASEKKRGI
>NZ_CP021269.1|WP_027224835.1|2331149_2331404_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKKSHVK
>NZ_CP021269.1|WP_014844324.1|2331393_2331690_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDYGISVIRVLHQSMDFNRHL
>NZ_CP021269.1|WP_010947832.1|2333427_2333637_+|cold-shock-protein
MSKTVNGVVKWFNEIKGFGFIEQEGGPDVFAHFKEISSSGFKTLTEGQRVQFIVTQGAKGLQAQNITAL
>NZ_CP021269.1|WP_014844326.1|2333876_2335283_+|ATP-dependent-RNA-helicase-DbpA
MIQSEHNDQHLSFSQFPLRQELIKSLASSNYENMTPIQMQSLPIILRNEDIIAQAKTGSGKTAAFALCLLNNLKISFFAVQALVLCPTRELAEQVSQAIRRLACLMPNVKIINLSGGIPMQPQLDSLRHGAHIIVGTPGRILKHLKNASLDLSQVKALVLDEADRMLDMGFFDDIKNIISVCPKQRQTLLFSATYPEEIKRLSKQFMKDPKEVHVVTPPEEIDIEQHFYEVSRHTQKFPLLKSLLLHYRPVSVLIFCNTKQETVEVTDQLINEGFSAIALNGDMEQIERDLAVLRFANQSCSILVATDVAARGLDIKELSAVINFDLAFDHDVHIHRIGRTGRAGSKGIALSIVTPADAQRICAIEDNYPHPIHWRNINELENHNTARLVPEMVTLCIASGKKDKIRPGDILGALTKDAGLASNTIGKINITAMYSYVAIHHSQADKAYQYLQSGKLKGRKVNVRKIN
>NZ_CP021269.1|WP_014844327.1|2335439_2336351_+|cation-diffusion-facilitator-family-transporter
MTIQKGLHERRALKISIAVTFLLAVVGILFGLLSGSLAIVFDGMFNMVDTVISILAFFVARLLTSKGNRRFQYGYWHIEPMVLVLNGSILILLCTYALVNAIGSLMSGGHELNFDYAFVFALLVFFLSTGMYFYLVKTNRKIKSEFLRLDIQSWLMSALISTSLLLAFGIAALLHGGAYGYFTPYIDPLILAILTAFLIFVPMAAVRDAMRDIFRMAPVGLDERIREFLDELIKQHDFKTYTSYVAKIGRAQFIEIHIVVPMDYPISSIETLDKIRNEIALAIGEDTPQRWLTIAFTANENWI
>NZ_CP021269.1|WP_076613127.1|2336442_2336961_+|MFS-transporter
MDFLEQHYHLSQIDATLVNGFSTLGYIVGAPFFGVLSHKVKNVIPIMFYAALIESILLAFNILYLHDLHLKMIFYAIVGFFTGAVTIGFSLVKDYVKPTMIGTWIGILNMGQICVGMILSLLFGELLDLFHDNYIWAAIPVILCSFISVYASYWLWKKSQSPELPARAPYKH

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Crispr_ID: NZ_CP021269_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP021269_2

2667319-2667485

Orphan

Consensus_repeat	Method
AAATTTACCGCGATAACAGTAATTT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP021269_2

>merge|NZ_CP021269|2|2667319-2667485|CRISPRCasFinder
AAATTTACCGCGATAACAGTAATTTTATGAGTTTAACATAAATAAATACACTGAAAATTAGAAAGCCGAGTAAATTTACCGCCATAACAGTAATTTATGGGGAATTAATGCAAAAAAATGCAATAATAAATTTATTTTAATCATTTTTACTGCTATAACAGTAATAT

>NZ_CP021269|2|2|2667319-2667485|CRISPRCasFinder
AAATTTACCGCGATAACAGTAATTT	TATGAGTTTAACATAAATAAATACACTGAAAATTAGAAAGCCGAGT
AAATTTACCGCCATAACAGTAATTT	ATGGGGAATTAATGCAAAAAAATGCAATAATAAATTTATTTTAATC
ATTTTTACTGCTATAACAGTAATAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP021269.1\|WP_027224435.1\|2657615_2658824_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340863
NZ_CP021269.1\|WP_027224434.1\|2658856_2659117_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239560
NZ_CP021269.1\|WP_027224429.1\|2667730_2668039_+\|HipA-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|274416
NZ_CP021269.1\|WP_014844539.1\|2675312_2676212_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_014844541.1\|2678058_2678967_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP021269.1\|WP_042233675.1\|2662658_2663366_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381179
NZ_CP021269.1\|WP_027224432.1\|2663633_2664860_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP021269.1\|WP_106202151.1\|2672907_2674689_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319844
NZ_CP021269.1\|WP_027224427.1\|2669096_2671664_+\|magnesium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319772
NZ_CP021269.1\|WP_014842401.1\|2663416_2663614_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_013101792.1\|2667506_2667734_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|213767
NZ_CP021269.1\|WP_015961552.1\|2659119_2660514_-\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NZ_CP021269.1\|WP_027224431.1\|2665494_2665968_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_027224430.1\|2666146_2667064_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176109
NZ_CP021269.1\|WP_027224426.1\|2671698_2672643_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NZ_CP021269.1\|WP_015961553.1\|2660518_2661154_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP021269.1\|WP_014844540.1\|2676373_2677813_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_027224433.1\|2661322_2662669_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP021269.1\|WP_027224428.1\|2668035_2668968_+\|HipA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377920
NZ_CP021269.1\|WP_014844538.1\|2674991_2675285_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277194

Protein	Function_ID	Function_description	E-value
NZ_CP021269.1\|WP_027224435.1\|2657615_2658824_-\|hypothetical-protein	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.7029e-13
NZ_CP021269.1\|WP_027224434.1\|2658856_2659117_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239560	cd03478, Rieske_AIFL_N, AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. AIFL shares 35% homology with human AIF (apoptosis-inducing factor), mainly in the Pyr_redox domain. AIFL is predominantly localized to the mitochondria. AIFL induces apoptosis in a caspase-dependent manner.	1.28129e-10
NZ_CP021269.1\|WP_014844541.1\|2678058_2678967_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.67439e-50
NZ_CP021269.1\|WP_027224429.1\|2667730_2668039_+\|HipA-N-terminal-domain-containing-protein	gnl\|CDD\|274416	TIGR03071, couple_hipA, HipA N-terminal domain. Although Pfam models pfam07805 and pfam07804 currently are called HipA-like N-terminal domain and HipA-like C-terminal domain, respectively, those models hit the central and C-terminal regions of E. coli HipA but not the N-terminal region. This model hits the N-terminal region of HipA and its homologs, and also identifies proteins that lack match regions for pfam07804 and pfam07805.	5.37248e-44
NZ_CP021269.1\|WP_027224432.1\|2663633_2664860_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.6053e-13
NZ_CP021269.1\|WP_106202151.1\|2672907_2674689_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319844	cd07544, P-type_ATPase_HM, P-type heavy metal-transporting ATPase; uncharacterized subfamily. Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP021269.1\|WP_027224427.1\|2669096_2671664_+\|magnesium-translocating-P-type-ATPase	gnl\|CDD\|319772	cd02077, P-type_ATPase_Mg, magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA. MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP021269.1\|WP_013101792.1\|2667506_2667734_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	1.63778e-24
NZ_CP021269.1\|WP_015961552.1\|2659119_2660514_-\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	1.15645e-28
NZ_CP021269.1\|WP_027224430.1\|2666146_2667064_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.68537e-55
NZ_CP021269.1\|WP_027224426.1\|2671698_2672643_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	6.70438e-18
NZ_CP021269.1\|WP_015961553.1\|2660518_2661154_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	5.31538e-37
NZ_CP021269.1\|WP_042233675.1\|2662658_2663366_-\|hypothetical-protein	gnl\|CDD\|381179	cd19916, OphMA_like, tetrapyrrole methylase family protein similar to Omphalotus olearius omphalotin methyltransferase (OphMA) and Dendrothele bispora dbOphMA. OphMA, is the precursor protein of the fungal cyclic peptide Omphalotin A. Omphalotin A is a potent nematicide, having 9 out of 12 of its residues methylated at the backbone amide. Omphalotin A derives from the C-terminus of OphMA (also known as OphA). OphMA catalyzes the automethylation of its own C-terminus using S-adenosyl methionine (SAM); this C terminus is subsequently released and macrocyclized by the protease OphP to give Omphalotin A.	5.61241e-84
NZ_CP021269.1\|WP_027224428.1\|2668035_2668968_+\|HipA-domain-containing-protein	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	1.81154e-59
NZ_CP021269.1\|WP_014844538.1\|2674991_2675285_-\|hypothetical-protein	gnl\|CDD\|277194	cd15841, SNARE_Qc, SNARE motif, subgroup Qc. SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins consist of coiled-coil helices (called SNARE motifs) which mediate the interactions between SNARE proteins, and a transmembrane domain. The SNARE complex mediates membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qc-, as well as Qa- and Qb-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle. Their SNARE motifs form twisted and parallel heterotetrameric helix bundles. Examples for members of the Qc SNAREs are C-terminal domains of SNAP23 and SNAP25, syntaxin 8, syntaxin 6, and Bet1.	1.22334e-13

>NZ_CP021269.1|WP_027224430.1|2666146_2667064_+|LysR-family-transcriptional-regulator
MDKLNLNLLRALYALLTCRHLTLASKKMGISQSSMSIYLKQLREHFHDDLLVRGQGNIMQLTPLANSLIGKARQALSLIETLFNTIETFNPLISERSFSIGMTDLMSILLTPSLIKRLEQEAPGVKLNIKHPSYLNTVEVFESGDIDLMIGMFERVPEGLKQQKLFQDEAVIVGGNNHPGIQKGKICIEELFKYPLIQFSLRETPFYNYFDRYLRQLGHDKRVSISLGQGIMPLFVLTDSHYLTLSIRKVAEKLSHLIPLSIASVPFEVDSFNCYQYWHQKDDADPGHRWLREMVLSIAKKSYLK
>NZ_CP021269.1|WP_027224431.1|2665494_2665968_+|hypothetical-protein
MRSRTEKLSSKRSIINHDHLITDEACMIGIYREGGDLSIYAESSEGIEHFSINRGNSLDMVILPHTLVGTWGHHQLLRTVEQAAQIRALRIRSHDYIEQSVTRKELEQFKEVFMLACKEEISNQPEIEDYLQTALGKLHGEPEMTYKPKFTEQCSIL
>NZ_CP021269.1|WP_027224432.1|2663633_2664860_-|MFS-transporter
MRNFFKNISALYLDVPKLTKTLLPIIILEHLVASFCLNISAYFKKVNYFQYEQIGEFISCYYWGCLFGSLIGGALTLYYKTSKISGWGLMLLGVCLFGLMNSISLWLIAISMFLVGFIGTITATANLTSLIRSVKDNEKLKLKVISLDLIIFNLCFSFVTFVLLDLSPLYILKYVQIMICLLVFVGIGSLIFYQDSIFNPPKLGSLGFKIILPERKQEFMLLMSMVLFFGLIFSMVKVVFAPTLIERFGSNMMSVIAASINPWVVFLIQPLIVGRIKNSNSIWFLGIGGLIVGLSYFMFGMVNSFELTAIVLVLLTFGEMMFGPLSKHFNIQLYRSGQEGVATGIWRAVFLGSGAIGPGLSGYVAEYYGTYVVWDCCALLGLLCFVFSLYLRKIQIKMPYSKLVLDNQ
>NZ_CP021269.1|WP_014842401.1|2663416_2663614_-|hypothetical-protein
MNTYEKLVYLATEPIDNKVVLCDKKGSKLKSSLAVQEELKDEFIHADLSIDIRRACETHLSFVLR
>NZ_CP021269.1|WP_042233675.1|2662658_2663366_-|hypothetical-protein
MTLEVQSVIQKCDCVIYLVNEPAIKRWIDENSKKAISLDAIYFSFQERKEAYQAICQEVINIVTKNQNTCFIIYGHPLILSNSAEQLIKEIKEESLDLEIEILPGISSIDTLLCDLCIDPGNGGLQAFEATEFINTNYKINTNSHLILWQIGVVGVKSIIQNDKDLVDSIERKIAIFQLQRKLLDWYNETHPIVLYVASIYPQIPCEKFDICLSNLDKVNIPRLATAYIKPDLIP
>NZ_CP021269.1|WP_027224433.1|2661322_2662669_+|hypothetical-protein
MFTTIDNNEGIVQTYWTEVRNKFEKADPYLSKLIDNVSPDKLPIYLLYFPYGMLKGDTKSSYMPLLDGGYIKLSDTGVDKKIVNDLGYGMYSSPLGMVLDKFIEYFIEFDDKIFTYYISGPGTIFNTGMLLKNKNSRNYSPNGVLKATAGARTAFMLPSINSHNGINKLSKLVNQDLTTPRNHNDHFELFKAINQHDNSNWKVCLAYFSEKWVKHLLTDPAWVEIKNYMLEAKNKNDSFSVNSAYYDIFYSKAQKDRNLRTSSPYLTNTAIHLIKIALGEHPGYVPATTANFLPIESIQKFISESFQLKRTPTIMVPHSLVYEKEKEPVYYSLQNPTTPHFLTKKNEKVTANQEIDIIYRILNKFIEEMSKQDSLLAGTVFSDISDHIRFNYFHNYPPKDSNLINNSRQLSKLDPRFNFSSYKNGESEFCFEGQFLRGCIQIQPNVKE
>NZ_CP021269.1|WP_015961553.1|2660518_2661154_-|flavin-reductase-family-protein
MFLQTSQKLPKGMFKACVVPRPIAWIGTKDSEGNHNLSPFSFFNIVCEEPPMVMFATTGAHNSGGAKDTLKNVEDTKEFTVNLVSYGSKEAMNITSLDFSRGISEFDMAEVDHLPSRLIQTPRVKESPISLECVYHESIQLPIPIHSNLINRMVIGKVVGIHLKPEILTKDKRIDTNKLNLIARVGYNSYTKVKAHFDLNRPCGCCNKLMD
>NZ_CP021269.1|WP_015961552.1|2659119_2660514_-|iron-containing-redox-enzyme-family-protein
MNKIINKLEANTPSKHIQQHFKELLNIYLHNPCFTDAAFLNPPNPYVRPLRTSDTLNINYDSAVALPEVYTNKNLIINKLLLNIYEQDLLFLANGNACEAKKDFANFYNPYYTAIGKALLPKLEQLAFNFLKDEIEIIGNWTKPKLLDYLINTILEQEKETSELCEAIVGSNNPIRAAKMLLIQMAPDFLSEASAMARALPGSFGIEQSELMKVFIDEYGYGVHETKHSTLFEATMLSANLNPTIHYYYNDYLATSLMLVNYFHCICKNKSDWFKYIGTLYYTEASIPHFNKQISKTLKNILPNINTKYFDEHVHIDKHHRRMVLEKIIATSIDKYGEEIIEDILFGFEAFKLLQNLADTDLAKQIQFSDQLDESYFPSNYTLLAESLTFNETELEITSAHLHADDELFQVTRGELIFYPNSLSPIILKANHRIVIPKGRLHSTVSQSANTQYVVQPIEISTGA
>NZ_CP021269.1|WP_027224434.1|2658856_2659117_-|Rieske-2Fe-2S-domain-containing-protein
MINKKHILNNRYFCKNDENYFIVKLNNKRFAIPDKCPHRGGPLSLGNICRESQRIQCPWHDGYFKISSLIKSAIPAVRVKDQIFYI
>NZ_CP021269.1|WP_027224435.1|2657615_2658824_-|hypothetical-protein
MVRHLKLIIILAFTLAGDILFGLALIWRVLALDGSAKTLGLFLCVITLVTFALQKSSVGFRRMLEKTPRRSFMWIRGVGVGFSIIFIPLLWHETTWLLYLVGAIATIINFLSILTLEAMMAHEVLEKRISSNKASRILQIAILTSSFLGASLLGTILALGNIVAVLLFCIATYLVGAICFSTQSDVGIQKISQVQTAKTASNQKMTYGNNLSVLRLAFIGLTLLMTQISAFNFLLPLIAQHEKFWTASQYGFIDAAAELGGLLATIIMFEKGIFSKLWIFAFLGIALVDILFFAVTDIYLISTATLFLGFCVSCFRIKQREYIYDSVSNTEEILEWTGRITAMTAIIKALTPLGLAFFISQPSFDLMIIGIVVGTVMLIVTSVLYFYTNKEFKQQIPSYSAV
>NZ_CP021269.1|WP_013101792.1|2667506_2667734_+|helix-turn-helix-transcriptional-regulator
MPTHEIANLVHYYRKQSGLSQQELAHLAGVGKTVIYDIEKGKESVRLNTLLKVLDVLNIQMKFETPFPQTTDNNS
>NZ_CP021269.1|WP_027224429.1|2667730_2668039_+|HipA-N-terminal-domain-containing-protein
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKNDYFGQLIIVGQDVVGAVTIEEIR
>NZ_CP021269.1|WP_027224428.1|2668035_2668968_+|HipA-domain-containing-protein
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNGHYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKSSMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKGKKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF
>NZ_CP021269.1|WP_027224427.1|2669096_2671664_+|magnesium-translocating-P-type-ATPase
MKINLDLNDLSTYDQDLLLNELNSSLEGLNNFQAQKRLTQYGTNEILRKPYHLIIIEAISHSINPLVAILFFAALISAFTGNVVNAAIIISIIIISIGLDYFQSHRALVAIKMLQKKIATTVTVLRENQWLEIPAKELVPGDLFRLSAGDMVPADSILLKSKDLHIHQSALTGESMPVEKEAIPLKTKPKNPLDALNVVFSGSSVIGGSATALAINTGSNSLYGHIAESLKKKPPHTEFEQGMMRFSTFIMKMVFLLVIFVFSINIYMHRPLLDSLLFAVALAVGLTPELLPMITTVTLASGAVRMSKKKVIIKNLSAIQNFGSIDILCSDKTGTLTSGEMNLTKYLDFSGKQSEFVMLLAYLNSVYITEIKSPFNIAVLKKARLNPLDLAILKHDHPDIQPYHKVDEIPFDFERRRSSVIVSKNENHLFICKGAPENIMSVCSYYDFAGERELFTEKEQKQCELLFQSLSSEGYRVLAIAYKLMDRQLKYTQSDEKEMIFAGFLAFTDPLLEDIPKVIKDLRHEGINIKILSGDNLIVTQHICQKVGMDTSRILTGEEISKISDDALPPLAEQIDIYARINPMQKQRIISALKKRGHVVGYLGDGINDVPSLHQADVGISVASAVDIAREAADIVLLEHHLKVLLNGIIEGRKSFRNVMKYLMMGTSSNFGNMISMAIAVLFLPFLPMLPRQILLNNLLYDISQITIPTDHVDPSSIHRYKRLDINIIRQFMFYVGPISSVFDFLTFFVMLKIFSANEALFQTGWFVESLATQTLVIFIIRTAKKPWQSMPSLPLTTTVLLIVMVGIWLPFSPFSGLFGFVPLPPLYFLFLVTATFTYLFLVELIKKKIMRKLY
>NZ_CP021269.1|WP_027224426.1|2671698_2672643_+|flippase-like-domain-containing-protein
MIKWISGFIILVVLIIVIGHFSQLRVFLGLIEQMKFSWLFFAVIFQSGTYMSLAAVWRLALRWFGEQISFFQLFLLSFSQLFVNQTIPTSGLSGVTIMTKFLLGRLITPKAIALAIALNVFSRQVAYLTSFIASIVVFWFYNELNKTLISLSLIFILIMVAVLILAALLWQQALKLKIPKLLNKYTSIRILINEIKKLDPKIVLNFKLFFPAVVFSVAIFIFDSLTLWTILKSLNLDLNFRLIFAAQVIASSIASLSFFPGGLGIFEGSLTGLLTFLGLSIEQAFTATILFRGFTYWLPMLPGFLLTQKELLRI
>NZ_CP021269.1|WP_106202151.1|2672907_2674689_+|heavy-metal-translocating-P-type-ATPase
MKIINVPYINVPLILIIIIGGLPLFIQISIKLVQGDLGADTLAALSLITGVILHEYLAACLIILMLASGQTLEVYARRKASSVLQALISRMPSKVHIRKNEQITDIPLSETQIGDEIIIYPHETCPVDGEVIDGHGTMDESYLTGEPYLIAKAPGVTVLSGAINGEALLVVKASKRPSDSRYAAIVEVLKEAEQKKPTLRRLGDQIGAIFTPIALFFALLAWYFSGDPIRFLSVLVIATPCPLLIAIPITIISAVSMAAKQAIIIKDPTILERLPTCQTAIFDKTGTLTYGKPTLTKIITTETYSHSDILQYAASLERYSKHPLSNSILDAAKERGLTLLQASEVFEKPGQGLLGKINDHSVQVTSRKKFLAKHPEEVGFLPEHSSGLECLILIDEQFAAVLQFHDAPREESHSFIHHLAPSHQFKKIMLVSGDRESEVKYLGKLLELTEIYSSQSPEQKLKIVRDETRKAPTLYMGDGINDAPALTAATVGIAFGQYSNVTAEAAGAVIMENTLNKVDELMHLSINTRKIALQSAIGGMLLSIIGMSFAALGFINPVTGAILQELIDILAIINALQLTWGSRVKIDLPGYKA
>NZ_CP021269.1|WP_014844538.1|2674991_2675285_-|hypothetical-protein
MKKNSSTKKILSSLSDTELQEKQELMMSEQDEQLDILLKTVTRTHEIAEAIQEELTSQNKLIDGLNEHVEKTDGKVKNTTKKVEALIPEVRSSCFLM
>NZ_CP021269.1|WP_014844539.1|2675312_2676212_-|hypothetical-protein
MFSPLQDPWSELEELGFNPEYLKRLKERAATSIEMTKNIEMLADYYEQFKEVGFTDSDLARIVSLVSFTADNRLANIGSRMMITLVCGGLNLVKAPLHFKPHKLTNMMLSLNGLEKLRTLVEMSKESGFTPLKNQAEFKAIFEKRCKKFPMLRVLWCYSDANESYMEYRKQDAIYKDWLSEEELHQLNRLSRISKTRDLHYWKRDTVRPVLLGDNYYSREDFGQTREEFEKAQDNPDAVESWCDSWANPFDQNPDSALTQSQEKSNQRNASKIPFFTVYENNGKSGVVDEQQSSNAFSN
>NZ_CP021269.1|WP_014844540.1|2676373_2677813_+|hypothetical-protein
MENKTKALNFLNRIERCLVPQSNPQIMKQLLSALGLDKLTTGNEEYKFFIQTIKKKSIDLNPLISKVKSDILNNDPLWTLLDYIEANELIDDAEIENASSTIQLQINLLCLLEAITITMANSNDFAHDIYNHMMKQRGKGATGNPFYNFLFGIPSRATLFERLKLISIDPGLTSIIFHRQMGENPETQADLDDFVSQNSLSGWNADIELANFDVASTSTLPAMGVNILEAVWEDATGHNKNTGGILNAQAGLGLIRVMEEQEYTTSFKLAETTLPQGTTLHSDFGYSLIPELKVDNSPKKVSQFHIDKQWMNLYNSWNLLFVIGNIDSVFVPLKLLMPSVFSAEPSNYKETRVLTLFLVANLFLNQQTLNNPLFSNNFSFRNGTVIMKKWGEINKNHASELLQQCKELDDLYNHVLGKNPHLNFGLKLFSYFQDSHQFRLTKKAQPSTSIDYSFFSGNTPSENNSEKMGVALHSSLYTK
>NZ_CP021269.1|WP_014844541.1|2678058_2678967_+|LysR-family-transcriptional-regulator
MNILSCLKGFITTVDCKSFSKAAQKLYISPSKLSKQITWLEEELKVTLLIRSTTRLTVTDSGHRLYEKSLQLFEQLEAVKVIATPDQLELNGVIRLYLTVTPAIPYLTTLSIQFMRQYPKIEVDIIVGSDTKELYSSTFDLAISFDDVKHSKLVCKRLFSIQRKVFASPGYIAQHGLPQTLDELPKHNCLINTLYGLQNKWVFNKKIIHVSGNFKSNNAGVLKQAAVADVGILWAPYFSVYEEIKNETLIPVLPQESSPDINLYAICPKSTVDEQKINLLLNFFCEKALSENIATSFIDGNN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

932887 : 939726

Acinetobacter_phage(42.86%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_027225204.1\|932887_933664_-	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	2.5e-57	48.2
WP_027225203.1\|933656_934691_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	1.2e-75	47.6
WP_011945952.1\|934668_935247_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.3e-55	53.2
WP_010946572.1\|935280_936006_-	LPS export ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.1e-17	28.3
WP_011215024.1\|936002_936512_-	lipopolysaccharide transport periplasmic protein LptA	NA	NA	NA	NA
WP_011945954.1\|936492_937062_-	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
WP_011945955.1\|937058_937586_-	3-deoxy-manno-octulosonate-8-phosphatase KdsC	A0A140XBD6	Dickeya_phage	1.4e-27	47.7
WP_010946576.1\|937599_938562_-	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	4.2e-38	34.1
WP_010946577.1\|938928_939726_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.3e-21	33.8

DBSCAN-SWA_2

1313220 : 1319157

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_027224128.1\|1313220_1314294_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.6e-30	28.6
WP_027224127.1\|1314278_1314893_+	riboflavin synthase	A0A2I2L4R9	Orpheovirus	1.3e-21	38.4
WP_027224126.1\|1314889_1316098_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	4.5e-98	48.5
WP_010946914.1\|1316105_1316573_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	9.2e-23	49.1
WP_027224125.1\|1316698_1318336_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	2.7e-154	52.5
WP_010946916.1\|1318332_1319157_+	3-deoxy-8-phosphooctulonate synthase	E3T537	Cafeteria_roenbergensis_virus	1.8e-53	43.9

DBSCAN-SWA_3

2241017 : 2251145

Bacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_027224474.1\|2241017_2242706_-	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	6.1e-16	30.4
WP_027224473.1\|2242837_2243845_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_011214268.1\|2243968_2245294_-	adenosylhomocysteinase	S4VPF6	Pandoravirus	1.8e-47	31.2
WP_027224472.1\|2245312_2246461_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.2e-127	58.7
WP_027224471.1\|2246674_2247787_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	3.8e-51	35.2
WP_010947740.1\|2247882_2249022_-	molecular chaperone DnaJ	A0A1V0SBY2	Catovirus	1.6e-23	26.9
WP_011946925.1\|2249210_2251145_-	molecular chaperone DnaK	G8DDB7	Micromonas_pusilla_virus	1.3e-147	49.6

DBSCAN-SWA_4

3284917 : 3330975

Ostreococcus_tauri_virus(16.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013101436.1\|3284917_3286039_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_027224494.1\|3286219_3286645_+	DUF1841 family protein	NA	NA	NA	NA
WP_014844943.1\|3286769_3287522_+	bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE	NA	NA	NA	NA
WP_027224495.1\|3287529_3288147_+	SCP2 sterol-binding domain-containing protein	NA	NA	NA	NA
WP_027224496.1\|3288236_3289886_+	ubiquinone biosynthesis regulatory protein kinase UbiB	C7U092	Ostreococcus_tauri_virus	2.7e-40	29.4
WP_011216738.1\|3289887_3290073_+	twin-arginine translocase TatA/TatE family subunit	NA	NA	NA	NA
WP_027224497.1\|3290069_3290339_+	twin-arginine translocase TatA/TatE family subunit	NA	NA	NA	NA
WP_027224498.1\|3290381_3290642_-	hypothetical protein	NA	NA	NA	NA
WP_027224499.1\|3290823_3291789_+	hypothetical protein	NA	NA	NA	NA
WP_027224500.1\|3291812_3292682_-	bifunctional methionine sulfoxide reductase B/A protein	NA	NA	NA	NA
WP_027224501.1\|3293343_3293532_+	DUF4169 family protein	NA	NA	NA	NA
WP_027224502.1\|3293749_3295684_-	primary-amine oxidase	NA	NA	NA	NA
WP_027224503.1\|3296616_3297888_-	peptidase S10	NA	NA	NA	NA
WP_076613102.1\|3297974_3298190_-	DUF1016 family protein	NA	NA	NA	NA
WP_027224504.1\|3298393_3299881_+	lpg2912 family Dot/Icm T4SS effector	NA	NA	NA	NA
WP_027224505.1\|3300042_3301485_-	ATP-binding protein	NA	NA	NA	NA
WP_027224506.1\|3301724_3302618_-	hypothetical protein	NA	NA	NA	NA
WP_027224507.1\|3302884_3303076_+	hypothetical protein	NA	NA	NA	NA
WP_014844956.1\|3303367_3303658_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_027224508.1\|3304485_3304989_-	hypothetical protein	NA	NA	NA	NA
WP_027224509.1\|3305098_3306145_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011947816.1\|3306453_3307416_-	lytic murein transglycosylase	NA	NA	NA	NA
WP_027224510.1\|3307966_3309145_+	serine hydrolase	A0A1D8EXR7	Mycobacterium_phage	4.7e-15	25.4
WP_027224511.1\|3309371_3309791_+	nucleotidyltransferase substrate binding protein	NA	NA	NA	NA
WP_027224512.1\|3309783_3310110_+	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_014844964.1\|3310266_3311460_-	ABC transporter permease	NA	NA	NA	NA
WP_011216765.1\|3311456_3312146_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.0e-33	41.0
WP_027224513.1\|3312138_3313284_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_027224514.1\|3313280_3314909_-	TolC family protein	NA	NA	NA	NA
WP_027224515.1\|3314952_3315783_-	symmetrical bis(5'-nucleosyl)-tetraphosphatase	S5MD19	Sinorhizobium_phage	8.7e-08	31.3
WP_027224516.1\|3315775_3317113_-	TraI domain-containing protein	NA	NA	NA	NA
WP_027224517.1\|3317149_3317920_-	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	NA	NA	NA	NA
WP_011947823.1\|3318255_3318657_+	aspartate 1-decarboxylase	NA	NA	NA	NA
WP_014844967.1\|3318762_3319488_+	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	2.4e-22	30.1
WP_011947825.1\|3319549_3319861_+	heat shock protein HspQ	NA	NA	NA	NA
WP_027224518.1\|3319898_3320093_-	hypothetical protein	NA	NA	NA	NA
WP_027219941.1\|3320111_3320825_-	NAD(P)H-flavin reductase	NA	NA	NA	NA
WP_106202128.1\|3320824_3322291_-	4-hydroxy-3-polyprenylbenzoate decarboxylase	NA	NA	NA	NA
WP_011216778.1\|3322435_3323698_-	transcription termination factor Rho	NA	NA	NA	NA
WP_010948620.1\|3324020_3324347_-	thioredoxin	A0A1J0GW78	Streptomyces_phage	3.2e-22	56.8
WP_106202129.1\|3324559_3325294_-	Lpg2936 family Dot/Icm T4SS effector methyltransferase	NA	NA	NA	NA
WP_106202130.1\|3325457_3326849_+	class II fumarate hydratase	NA	NA	NA	NA
WP_050598230.1\|3326935_3327568_+	hypothetical protein	NA	NA	NA	NA
WP_062740918.1\|3327810_3329022_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_027228584.1\|3329566_3330025_+\|transposase	IS66 family transposase zinc-finger binding domain-containing protein	NA	NA	NA	NA
WP_161498646.1\|3330076_3330298_+\|transposase	transposase	NA	NA	NA	NA
WP_080272279.1\|3330301_3330634_+\|transposase	transposase	NA	NA	NA	NA
WP_050598215.1\|3330642_3330975_+\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP021269

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection