CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP027371	Escherichia coli strain 2015C-3905 chromosome, complete genome	5 crisprs	DinG,cas1,cas3f,cas8f,cas5f,cas7f,cas6f,cas3,c2c9_V-U4,DEDDh,csa3,cas2,cas6e,cas5,cas7,cse2gr11,cas8e	0	22	8	0
NZ_CP027372	Escherichia coli strain 2015C-3905 plasmid unnamed	0 crisprs	NA	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP027371_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027371_1

878018-878885

TypeI-F

I-F

Consensus_repeat	Method
GTTCACTGCCGTACAGGCAGCTTAGAAA	PILER-CR
GTTCACTGCCGTACAGGCAGCTTAGAAA	CRISPRCasFinder
GTTCACTGCCGTACAGGCAGCTTAGAAA	CRT

14 spacers

cas1,cas3f,cas8f,cas5f,cas7f,cas6f

The CRISPR arrays of NZ_CP027371_1

>merge|NZ_CP027371|1|878018-878885|PILER-CR,CRISPRCasFinder,CRT
GTTCACTGCCGTACAGGCAGCTTAGAAAACATCATGAACGCGCAGCAATATGCCGCAATTGTTCACTGCCGTACAGGCAGCTTAGAAACGGCAGAAAAACCGGTCGCGCTAATGGAGAAAGTTCACTGCCGTACAGGCAGCTTAGAAAGCCGCAACTCACAATAACAGAATCACAAATTAGTTCACTGCCGTACAGGCAGCTTAGAAATGCCAGATATTTCAGATCATGAACGGTTGCGCGTTCACTGCCGTACAGGCAGCTTAGAAAAGGAAATTTCCGGCGACTAACGAAACAGGTTGGTTCACTGCCGTACAGGCAGCTTAGAAAGTCATCGGTATCGTCACGCGCAAGGGATTCAAGTTCACTGCCGTACAGGCAGCTTAGAAAGTTGTAATTTTCGTACCCGGCGCGATCGCAATGTTCACTGCCGTACAGGCAGCTTAGAAAAATCGTAGGGCACACCCTTACGGCAGTTAAAAGTTCACTGCCGTACAGGCAGCTTAGAAAAATCAGCCCGATCACTGTGCTGCGCCCCGCTCGTTCACTGCCGTACAGGCAGCTCAGAAATCATTGGAATACATGAGTTGCGCCCATTTTGTGTTCACTGCCGTACAGGCAGCTTAGAAATGGCATGCAATCACTACAGCTATTAATTTCTAGTTCACTGCCGTACAGGTAGCTTAGAAATGAACGCGATCCGGGCGATTCGGGAGTTTTCGGTTCACTGCCGTACAGGCAGCTTAGAAATTCACCGAGTGGGTGCTCGTGCTGAATGAACTGTTCACTGCCGTACAGGCCGTTTAGAAACACATATACGCGAACGTCATTTTGCAGTAGCAGTTCACTGCCGTACAGGCAGTATTCACA

>NZ_CP027371|1|1|878018-878825|PILER-CR
GTTCACTGCCGTACAGGCAGCTTAGAAA	ACATCATGAACGCGCAGCAATATGCCGCAATT
GTTCACTGCCGTACAGGCAGCTTAGAAA	CGGCAGAAAAACCGGTCGCGCTAATGGAGAAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	GCCGCAACTCACAATAACAGAATCACAAATTA
GTTCACTGCCGTACAGGCAGCTTAGAAA	TGCCAGATATTTCAGATCATGAACGGTTGCGC
GTTCACTGCCGTACAGGCAGCTTAGAAA	AGGAAATTTCCGGCGACTAACGAAACAGGTTG
GTTCACTGCCGTACAGGCAGCTTAGAAA	GTCATCGGTATCGTCACGCGCAAGGGATTCAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	GTTGTAATTTTCGTACCCGGCGCGATCGCAAT
GTTCACTGCCGTACAGGCAGCTTAGAAA	AATCGTAGGGCACACCCTTACGGCAGTTAAAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	AATCAGCCCGATCACTGTGCTGCGCCCCGCTC
GTTCACTGCCGTACAGGCAGCTCAGAAA	TCATTGGAATACATGAGTTGCGCCCATTTTGT
GTTCACTGCCGTACAGGCAGCTTAGAAA	TGGCATGCAATCACTACAGCTATTAATTTCTA
GTTCACTGCCGTACAGGTAGCTTAGAAA	TGAACGCGATCCGGGCGATTCGGGAGTTTTCG
GTTCACTGCCGTACAGGCAGCTTAGAAA	TTCACCGAGTGGGTGCTCGTGCTGAATGAACT
GTTCACTGCCGTACAGGCCGTTTAGAAA

>NZ_CP027371|1|1|878018-878885|CRISPRCasFinder
GTTCACTGCCGTACAGGCAGCTTAGAAA	ACATCATGAACGCGCAGCAATATGCCGCAATT
GTTCACTGCCGTACAGGCAGCTTAGAAA	CGGCAGAAAAACCGGTCGCGCTAATGGAGAAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	GCCGCAACTCACAATAACAGAATCACAAATTA
GTTCACTGCCGTACAGGCAGCTTAGAAA	TGCCAGATATTTCAGATCATGAACGGTTGCGC
GTTCACTGCCGTACAGGCAGCTTAGAAA	AGGAAATTTCCGGCGACTAACGAAACAGGTTG
GTTCACTGCCGTACAGGCAGCTTAGAAA	GTCATCGGTATCGTCACGCGCAAGGGATTCAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	GTTGTAATTTTCGTACCCGGCGCGATCGCAAT
GTTCACTGCCGTACAGGCAGCTTAGAAA	AATCGTAGGGCACACCCTTACGGCAGTTAAAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	AATCAGCCCGATCACTGTGCTGCGCCCCGCTC
GTTCACTGCCGTACAGGCAGCTCAGAAA	TCATTGGAATACATGAGTTGCGCCCATTTTGT
GTTCACTGCCGTACAGGCAGCTTAGAAA	TGGCATGCAATCACTACAGCTATTAATTTCTA
GTTCACTGCCGTACAGGTAGCTTAGAAA	TGAACGCGATCCGGGCGATTCGGGAGTTTTCG
GTTCACTGCCGTACAGGCAGCTTAGAAA	TTCACCGAGTGGGTGCTCGTGCTGAATGAACT
GTTCACTGCCGTACAGGCCGTTTAGAAA	CACATATACGCGAACGTCATTTTGCAGTAGCA
GTTCACTGCCGTACAGGCAGTATTCACA

>NZ_CP027371|1|1|878018-878885|CRT
GTTCACTGCCGTACAGGCAGCTTAGAAA	ACATCATGAACGCGCAGCAATATGCCGCAATT
GTTCACTGCCGTACAGGCAGCTTAGAAA	CGGCAGAAAAACCGGTCGCGCTAATGGAGAAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	GCCGCAACTCACAATAACAGAATCACAAATTA
GTTCACTGCCGTACAGGCAGCTTAGAAA	TGCCAGATATTTCAGATCATGAACGGTTGCGC
GTTCACTGCCGTACAGGCAGCTTAGAAA	AGGAAATTTCCGGCGACTAACGAAACAGGTTG
GTTCACTGCCGTACAGGCAGCTTAGAAA	GTCATCGGTATCGTCACGCGCAAGGGATTCAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	GTTGTAATTTTCGTACCCGGCGCGATCGCAAT
GTTCACTGCCGTACAGGCAGCTTAGAAA	AATCGTAGGGCACACCCTTACGGCAGTTAAAA
GTTCACTGCCGTACAGGCAGCTTAGAAA	AATCAGCCCGATCACTGTGCTGCGCCCCGCTC
GTTCACTGCCGTACAGGCAGCTCAGAAA	TCATTGGAATACATGAGTTGCGCCCATTTTGT
GTTCACTGCCGTACAGGCAGCTTAGAAA	TGGCATGCAATCACTACAGCTATTAATTTCTA
GTTCACTGCCGTACAGGTAGCTTAGAAA	TGAACGCGATCCGGGCGATTCGGGAGTTTTCG
GTTCACTGCCGTACAGGCAGCTTAGAAA	TTCACCGAGTGGGTGCTCGTGCTGAATGAACT
GTTCACTGCCGTACAGGCCGTTTAGAAA	CACATATACGCGAACGTCATTTTGCAGTAGCA
GTTCACTGCCGTACAGGCAGTATTCACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027371.1\|WP_001101569.1\|880037_883271_+\|type-I-F-CRISPR-associated-helicase-Cas3	cas3f	cd09673_cas3f_CAS-I-F	gnl\|CDD\|274201
NZ_CP027371.1\|WP_001356126.1\|867616_868312_-\|aquaporin-Z	unknown	unknown	gnl\|CDD\|235453
NZ_CP027371.1\|WP_000241204.1\|875177_875498_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP027371.1\|WP_000120900.1\|884905_885829_+\|type-I-F-CRISPR-associated-protein-Csy2	cas5f	pfam09614_cas5f_CAS-I-F	gnl\|CDD\|378221
NZ_CP027371.1\|WP_000410785.1\|874630_874855_-\|cold-shock-like-protein-CspD	unknown	unknown	gnl\|CDD\|77494
NZ_CP027371.1\|WP_000188180.1\|872611_874558_+\|macrolide-ABC-transporter-ATP-binding-protein/permease-MacB	unknown	unknown	gnl\|CDD\|182528
NZ_CP027371.1\|WP_000458817.1\|864426_866079_-\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|235391
NZ_CP027371.1\|WP_000599806.1\|868737_870396_+\|ATP-dependent-endonuclease	unknown	unknown	gnl\|CDD\|226121
NZ_CP027371.1\|WP_000415804.1\|883601_884909_+\|type-I-F-CRISPR-associated-protein-Csy1	cas8f	pfam09611_cas8f_CAS-I-F	gnl\|CDD\|187866
NZ_CP027371.1\|WP_000934053.1\|875528_877805_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	unknown	unknown	gnl\|CDD\|236828
NZ_CP027371.1\|WP_000350179.1\|886851_887406_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09739_cas6f_CAS-I-F:CAS-IV	gnl\|CDD\|187870
NZ_CP027371.1\|WP_001043602.1\|891119_892886_-\|cysteine/glutathione-ABC-transporter-permease/ATP-binding-protein-CydD	unknown	unknown	gnl\|CDD\|236870
NZ_CP027371.1\|WP_001355621.1\|870392_871349_-\|DUF535-domain-containing-protein	unknown	unknown	gnl\|CDD\|225537
NZ_CP027371.1\|WP_000097888.1\|879057_880041_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	cas1	cd09718_cas1_CAS-I-F	gnl\|CDD\|132676
NZ_CP027371.1\|WP_001029754.1\|885839_886841_+\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	pfam09615_cas7f_CAS-I-F	gnl\|CDD\|378222
NZ_CP027371.1\|WP_001241678.1\|888651_889356_-\|leucyl/phenylalanyl-tRNA--protein-transferase	unknown	unknown	gnl\|CDD\|234720
NZ_CP027371.1\|WP_001040187.1\|888148_888367_-\|translation-initiation-factor-IF-1	unknown	unknown	gnl\|CDD\|178954
NZ_CP027371.1\|WP_001202179.1\|889397_891119_-\|cysteine/glutathione-ABC-transporter-ATP-binding-protein/permease-CydC	unknown	unknown	gnl\|CDD\|236865
NZ_CP027371.1\|WP_000491142.1\|866222_867122_-\|L-lysine-exporter-LysO	unknown	unknown	gnl\|CDD\|225287
NZ_CP027371.1\|WP_000746460.1\|871499_872615_+\|macrolide-transporter-subunit-MacA	unknown	unknown	gnl\|CDD\|183211

Protein	Function_ID	Function_description	E-value
NZ_CP027371.1\|WP_001101569.1\|880037_883271_+\|type-I-F-CRISPR-associated-helicase-Cas3	gnl\|CDD\|274201	TIGR02562, conserved_hypothetical_protein, CRISPR-associated helicase Cas3, subtype I-F/YPEST. The helicase in many CRISPR-associated (cas) gene clusters is designated Cas3, and most Cas3 proteins are described by model TIGR01587. Members of this family are considerably larger, show a number of motifs in common with TIGR01587 sequences, and replace Cas3 in some CRISPR/cas loci in a number of Proteobacteria, including Yersinia pestis, Chromobacterium violaceum, Erwinia carotovora subsp. atroseptica SCRI1043, Photorhabdus luminescens subsp. laumondii TTO1, Legionella pneumophila, etc.	0
NZ_CP027371.1\|WP_001356126.1\|867616_868312_-\|aquaporin-Z	gnl\|CDD\|235453	PRK05420, PRK05420, aquaporin Z; Provisional.	6.59307e-144
NZ_CP027371.1\|WP_000241204.1\|875177_875498_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	5.38111e-48
NZ_CP027371.1\|WP_000120900.1\|884905_885829_+\|type-I-F-CRISPR-associated-protein-Csy2	gnl\|CDD\|378221	pfam09614, Cas_Csy2, CRISPR-associated protein (Cas_Csy2). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.	1.25923e-136
NZ_CP027371.1\|WP_000410785.1\|874630_874855_-\|cold-shock-like-protein-CspD	gnl\|CDD\|77494	PRK09937, PRK09937, cold shock-like protein CspD.	1.48016e-47
NZ_CP027371.1\|WP_000188180.1\|872611_874558_+\|macrolide-ABC-transporter-ATP-binding-protein/permease-MacB	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	0
NZ_CP027371.1\|WP_000458817.1\|864426_866079_-\|hydroxylamine-reductase	gnl\|CDD\|235391	PRK05290, PRK05290, hybrid cluster protein; Provisional.	0
NZ_CP027371.1\|WP_000599806.1\|868737_870396_+\|ATP-dependent-endonuclease	gnl\|CDD\|226121	COG3593, COG3593, Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair].	0
NZ_CP027371.1\|WP_000415804.1\|883601_884909_+\|type-I-F-CRISPR-associated-protein-Csy1	gnl\|CDD\|187866	cd09735, Csy1_I-F, CRISPR/Cas system-associated protein Csy1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins; Predicted subunit of the Cascade complex; signature gene for I-F subtype; also known as Csy1 family.	1.00114e-162
NZ_CP027371.1\|WP_000934053.1\|875528_877805_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	gnl\|CDD\|236828	PRK11034, clpA, ATP-dependent Clp protease ATP-binding subunit; Provisional.	0
NZ_CP027371.1\|WP_000350179.1\|886851_887406_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|187870	cd09739, Cas6_I-F, CRISPR/Cas system-associated RAMP superfamily protein Cas6f. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6f is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-F subtype; Possesses RRM fold; also known as Csy4 family.	1.69983e-97
NZ_CP027371.1\|WP_001043602.1\|891119_892886_-\|cysteine/glutathione-ABC-transporter-permease/ATP-binding-protein-CydD	gnl\|CDD\|236870	PRK11174, PRK11174, cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed.	0
NZ_CP027371.1\|WP_001355621.1\|870392_871349_-\|DUF535-domain-containing-protein	gnl\|CDD\|225537	COG2990, VirK, Uncharacterized protein conserved in bacteria [Function unknown].	1.27645e-131
NZ_CP027371.1\|WP_000097888.1\|879057_880041_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|132676	TIGR03637, cas1_YPEST, CRISPR-associated endonuclease Cas1, subtype I-F/YPEST. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the YPEST subtype of CRISPR/Cas system.	0
NZ_CP027371.1\|WP_001029754.1\|885839_886841_+\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|378222	pfam09615, Cas_Csy3, CRISPR-associated protein (Cas_Csy3). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	0
NZ_CP027371.1\|WP_001241678.1\|888651_889356_-\|leucyl/phenylalanyl-tRNA--protein-transferase	gnl\|CDD\|234720	PRK00301, aat, leucyl/phenylalanyl-tRNA--protein transferase; Reviewed.	3.45002e-139
NZ_CP027371.1\|WP_001040187.1\|888148_888367_-\|translation-initiation-factor-IF-1	gnl\|CDD\|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	8.41354e-49
NZ_CP027371.1\|WP_001202179.1\|889397_891119_-\|cysteine/glutathione-ABC-transporter-ATP-binding-protein/permease-CydC	gnl\|CDD\|236865	PRK11160, PRK11160, cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed.	0
NZ_CP027371.1\|WP_000491142.1\|866222_867122_-\|L-lysine-exporter-LysO	gnl\|CDD\|225287	COG2431, COG2431, Predicted membrane protein [Function unknown].	8.74036e-118
NZ_CP027371.1\|WP_000746460.1\|871499_872615_+\|macrolide-transporter-subunit-MacA	gnl\|CDD\|183211	PRK11578, PRK11578, macrolide transporter subunit MacA; Provisional.	0

>NZ_CP027371.1|WP_000934053.1|875528_877805_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEERDTQPTLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAAYLLRKHEVSRLDVVNFISHGTRKDEPTQSSDPGSQPNSEEQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPMLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKAHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIHQDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANELLFGSLVDGGQVTVALDKEKNELTYGFQSAQKHKAEAAH
>NZ_CP027371.1|WP_000241204.1|875177_875498_+|ATP-dependent-Clp-protease-adapter-ClpS
MVKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA
>NZ_CP027371.1|WP_000410785.1|874630_874855_-|cold-shock-like-protein-CspD
MEKGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHASVIVPVEVEAAVA
>NZ_CP027371.1|WP_000188180.1|872611_874558_+|macrolide-ABC-transporter-ATP-binding-protein/permease-MacB
MTPLLELKDIRRSYPAGDEQVEVLKGITLDIYAGEMVAIVGASGSGKSTLMNILGCLDKATSGTYRVAGQDVATLDADALAQLRREHFGFIFQRYHLLSHLTAEQNVEVPAVYAGLERKQRLLRAQELLQRLGLEDRTEYYPAQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSGEEVMAILHQLRDRGHTVIIVTHDPQVAAQAERVIEIRDGEIVRNPPAIEKVNVAGGTEPVVNTVSGWRQFVSGFNEALTMAWRALAANKMRTLLTMLGIIIGIASVVSIVVVGDAAKQMVLADIRSIGTNTIDVYPGKDFGDDDPQYQQALKYDDLIAIQKQPWVASATPAVSQNLRLRYNNVDVAASANGVSGDYFNVYGMTFSEGNTFNQEQLNGRAQVVVLDSNTRRQLFPHKADVVGEVILVGNMPARVIGVAEEKQSMFGSSKVLRVWLPYSTMSGRVMGQSWLNSITVRVKEGFDSAEAEQQLTRLLSLRHGKKDFFTWNMDGVLKTVEKTTRTLQLFLTLVAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARASDVLQQFLIEAVLVCLVGGALGITLSLLIAFTLQLFLPGWEIGFSPLALLLAFLCSTVTGILFGWLPARNAARLDPVDALARE
>NZ_CP027371.1|WP_000746460.1|871499_872615_+|macrolide-transporter-subunit-MacA
MKKRKTVKKRYVIALVIVIAGLITLWRILNAPVPTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEAELKLARVTYSRQQRLAQTQAVSQQDLDTAATEMAVKQAQIGTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGQIKDVLPTPEKVNDAIFYYARFEVPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEVVIGEAKPGAAQ
>NZ_CP027371.1|WP_001355621.1|870392_871349_-|DUF535-domain-containing-protein
MNMSQLTERTFTPSESLSSLSLFLSLARGQCRPGKFWHRRSFRQKFLLRSLIMPRLSVEWMNELSHWPNLNVLLTRQPRLPVRLHRPYLAANLSRKQLLEALRYHYALLRGCMSAEEFSLYLNTPGLQLAKLEGKNGEQFTLELTMMISMDKEGDSTILFRNSEGIPLAEITFTLCEYQGKRTMFIGGLQGAKWEIPHQEIQNATKACHGLFPKRLVMEAACLFAQRLQVEQIIAVSNETHIYRSLRYRDKEGKIHADYNAFWESVGGVCDAERHYRLPAQIARKEIAEIASKKRAEYRRRYEMLDAIQPQMATMFRG
>NZ_CP027371.1|WP_000599806.1|868737_870396_+|ATP-dependent-endonuclease
MILERVEIVGFRGINRLSLMLEQNNVLIGENAWGKSSLLDALTLLLSPESDLYHFERDDFWFPPGDINGREHHLHIILTFRESLPGRHRVRRYRPLEACWTPCTDGYHRIFYRLEGESAEDGSVMTLRSFLDKDGHPIDVEDINDQARHLVRLMPVLRLRDARFMRRIRNGTVPNVPNVEVTARQLDFLARELSSHPQNLSDGQIRQGLSAMVQLLEHYFSEQGAGQARYRLMRRRASNEQRSWRYLDIINRMIDRPGGRSYRVILLGLFATLLQAKGTLRLDKDARPLLLIEDPETRLHPIMLSVAWHLLNLLPLQRIATTNSGELLSLTPVEHVCRLVRESSRVAAWRLGPSGLSTEDSRRISFHIRFNRPSSLFARCWLLVEGETETWVINELARQCGHHFDAEGIKVIEFAQSGLKPLVKFARRMGIEWHVLVDGDEAGKKYAATVRSLLNNDREAEREHLTALPALDMEHFMYRQGFSDVFHRVAQIPENVPMNLRKIISKAIHRSSKPDLAIEVAMEAGRRGVDSVPTLLKKMFSRVLWLARGRAD
>NZ_CP027371.1|WP_001356126.1|867616_868312_-|aquaporin-Z
MFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAGVALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPAKEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFASNGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGTTDKFAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGGWALEQLWFFWMVPIVGGIIGGLIYRTLLEKRD
>NZ_CP027371.1|WP_000491142.1|866222_867122_-|L-lysine-exporter-LysO
MFSGLLIILVPLIVGYLIPLRQQAALKVINQLLSWMVYLILFFMGISLAFLDNLASNLLAILHYSAVSITVILLCNIAALMWLERGLPWRNHHQQEKLPSRIAMALESLKLCGVVVIGFAIGLSGLAFLQHATEASEYTLILLLFLVGIQLRNNGMTLKQIVLNRRGMIVAVVVVVSSLIGGLINAFILDLPINTALAMASGFGWYSLSGILLTESFGPVIGSAAFFNDLARELIAIMLIPGLIRRSRSTALGLCGATSMDFTLPVLQRTGGLDMVPAAIVHGFILSLLVPILIAFFSA
>NZ_CP027371.1|WP_000458817.1|864426_866079_-|hydroxylamine-reductase
MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGEDFSAVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
>NZ_CP027371.1|WP_000097888.1|879057_880041_+|type-I-F-CRISPR-associated-endonuclease-Cas1
MSSNYLTPSDLKTILHSKRANIYYLEKCRVQVNGGRVEYVTSEGKESYYWNIPIANTTALMLGMGTSVTQAAMREFAHAGVMVGFCGTDGTPLYSANEVDVDVSWLSPQSEYRPTEYLQQWVSFWFVEVKRLAAAKRFQLIRLAHIEKHWTSAKMQREHAFQPDVNALHTLLNRTREEIDAAENHTQLMLVEAKLTKALYKMVSQTVGYGDFTRAKRGGGIDMANRFLDQGNYLAYGLAAVAAWVTGIPHGLAVMHGKTRRGGLVFDLADLIKDALVMPQAFIAAMAGEDAQEFRQRCINIFQQADALDVMITSLQETAQALAKADQ
>NZ_CP027371.1|WP_001101569.1|880037_883271_+|type-I-F-CRISPR-associated-helicase-Cas3
MNVLIISRCTKNARVESCRIIEQFAERTGDAAWQTVITLEGVNTLRRLLRKTARRNTAVACHWLKKNGQMELMWIVGNIRHFNAQGRVPTNRTTQTSLVNKEENRWQCAESIALLAAIAGLFHDFGKSGRSFQQSLTQKNARSYQPYRHEWISLRLFQAFVGDRPDDVWLAKLGELTADDESAILERLLKDTPQFSDSPFTSLQPLAKTVGWLILSHHRIPENLSPQPEQSCKGCESWLERQLNADWNAVNHRRDDWSQQDFAHVWQFPSGTPLQSASWREKARQIARRASNALGLKTYGQMEQLFPLHMARFCLMLADHYYSSRDAQQKWQDPEYIVWANSDRQSGTLKQRVDEHLVGVAHHAYLLGRQLMHTRASLPAIARHKGFSQRATDVKYRWQNKAWDVARALRERSREEGFFGVNIASTGCGKTFANARIMYALADEREGCRFTVALGLRTLTLQTGDALRSRLGLGEDELAVLIGSAAVKQLWQQEKIDNDCGSASQESPAEEQQFVKYEGSLHNGALEKWLKDDSKLKALVSAPILVATIDHLISATEGVRGGKQLPAMLRLLTCDLVLDEPDDFDIADLHAVCRLMNWAGMLGTRVLLSSATLPPGLIQALFAAYLAGRKMWQASCGTNGRPVNICCAWFDENDADATQISDGAAFRDAHTKFVARRAVMLAEKERLHFGRVASISSASVAIQDVTESVAQTVHTQMLKLHQAHRQLHESGKTVSLGLVRFSNINPLVAVTKALIAIPSPENVCIHYCVYHSRHPLAVRSDIEKRLDRAFTRHNELDFWNNEDIADALHNRPESHHLFVVLGTSVIEVGRDWDADWGIIEPSSMRSIIQFAGRIQRHRRNVPTSENLVILRSNIKSLQKKAPAFCKPGFETKEHLLNSHDICELIPIADYRTINALPRILSANNDNKLAELEHSRLSAELMSSKSKHVVAAQWWRAPLSWNGWIQRQTPFRYSPLPEAVFFLHMDDEESEVRFYSRTGDNERKAQGNFRREEVRCASGVACWGVMDYQHVLLNLADKQGCEIQRVGEMFAEVRVPASEEDAVDDWRYHPWLGVFRNQ
>NZ_CP027371.1|WP_000415804.1|883601_884909_+|type-I-F-CRISPR-associated-protein-Csy1
MEKTALIQFITDYIASRRQPKIDAFEKEAAKRLEQGEDASVIALERQELEARYLPRNWLTDAANRIRSIRIISHGAKYSNGDSKAYGRYLEKFVSEGYLNTASLAIIKEDAEGNAAVFDVAKLLLTEINGDSLLASLKRGDYHSLNVFALNDEQLKQWVECFSKAYASEWIKAHKLSKQIYFPVDDGYHLLCPLFSSSLAQAMYEKLTAVRFSEESKVIRDAHKAGKWHSQPDIRFPNLAEMHYGGGNQQNISLLNSARIGRVWLLPSMPPTWATLDRAPQNMRSIFALRGDFNRAASGIIARMTYLLKVDINNVHIRTARAKYIDELIDLLFMQASAFQQEKWQGWSAQSQDLPRHQQLWLDPWRSLSDETFKQEREKNDWQETVADDFARWLNYRLKKSSFDVGAVEQKEWRSQSLFAQRMREMEAVLQEALK
>NZ_CP027371.1|WP_000120900.1|884905_885829_+|type-I-F-CRISPR-associated-protein-Csy2
MSYLLLLPHIRIENANAVSGLTWGFPSMTHFLGYVHALSRKVVDEFGVSFDGCAVVSHEQHIQAYSSGRDFQFALTRNPLTREGKTASFNEEGRMHLTVSLLIECNGEITNGEYGRKALCDHLKMLCQSHKLAGGSIVDMREPQLFHAPEDEKQLRKIIWRLMPGYALYDRSEWLAERHQQHPDISLLDAWLDFAAVKYQAESPAEDNSAKWTYQPKPMPGFLVPLMCGYQRISPVYAPGEVENARDTVTPFAFAEAVYGIGEWRGLHRITDLQPLMWHYRTTDTGYYCSATPVVDDFTFNEYDDLE
>NZ_CP027371.1|WP_001029754.1|885839_886841_+|type-I-F-CRISPR-associated-protein-Csy3
MAKAPVAIKTASVLAFERKLATSDAVMYAGNWQGNVWQPIEIQEKAVRGTISNRLKNTITSDSTKLDAEIQKANLQRVDVASLPVDADTLKVVFTLRVLGNLSTPSVCNDMAYQEALSGVIEGYISEHGFKELALRYALNLANGRFLWRNRIGAEQIQVKVTANDTFWTFNSHDFSLRQFDQGQAAVTQLAAIIEQGLSAKEWVMLTVEAQVRLGGGQEVFPSQELVLDSNSSKSRVLYQVAGIAGIHSQKIGNALRTIDTWHPKVDELGAIAVEPYGSVTSRGVACRQPKEKLDFYTLLDNWVTKGVKPDVDQQHYVMAVLIRGGVFGEKSE
>NZ_CP027371.1|WP_000350179.1|886851_887406_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MDHYLEIRVLPDPEFSSEMLMAALFAKLHRALGARGQGDIGVSFPDVNVTPGARLRLHGSAPALQELEASTWRKGLTDYCQCSPVTPVPEIKGWRVVSRVQVKSNPQRLLRRSVKKGWLTEEQAIERLATQAELRTDLPFLNMKSLSSQQQFKLFIRHGDLLTEPVKGEFSSYGLSATATIPWF
>NZ_CP027371.1|WP_001040187.1|888148_888367_-|translation-initiation-factor-IF-1
MAKEDNIEMQGTVLETLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
>NZ_CP027371.1|WP_001241678.1|888651_889356_-|leucyl/phenylalanyl-tRNA--protein-transferase
MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQRGIFPWFSPGDPILWWSPDPRAVLWPESLHISRSMKRFHKRSPYRVTMNYAFGQVIEGCASDREEGTWITRGVVEAYHRLHELGHAHSIEVWREDELVGGMYGVAQGTLFCGESMFSRMENASKTALLVFCEEFIGHGGKLIDCQVLNDHTASLGACEIPRRDYLNYLNQMRLGRLPNNFWVPRCLFSPQE
>NZ_CP027371.1|WP_001202179.1|889397_891119_-|cysteine/glutathione-ABC-transporter-ATP-binding-protein/permease-CydC
MRALLPYLALYKRHKWMLSLGIVLAIVTLLASIGLLTLSGWFLSASAVAGVAGLYSFNYMLPAAGVRGAAITRTAGRYFERLVSHDATFRVLQHLRIYTFSKLLPLSPAGLARYRQGELLNRVVADVDTLDHLYLRVISPLVGAFVVIMVVTIGLSFLDFTLAFTLGGIMLLTLFLMPPLFYRAGKSTGQNLTHLRGQYRQQLTAWLQGQAELTIFGASDRYRTQLENTEIQWLEAQRRQSELTALSQAIMLLIGALAVILMLWMASGGVGGNAQPGALIALFVFCALAAFEALAPVTGAFQHLGQVIASAVRITDLTDQKPEVTFPDTQTHVANRVSLTLRDVQFTYPEQSQQALKGISLQVNAGEHIAILGRTGCGKSTLLQLLTRAWDPQQGEILLNDSPIASLNEAALRQTISVVPQRVHLFSATLRDNLLLASPGSSDEALAESLRRVGLEKLLEDAGLNSWLGEGGRQLSGGELRRLAIARALLHDAPLVLLDEPTEGLDATTESQILELLAEMMREKTVLMVTHRLRGLSRFQQIIVMDNGQIIEQGTHAELLARQGRYYQFKQGL
>NZ_CP027371.1|WP_001043602.1|891119_892886_-|cysteine/glutathione-ABC-transporter-permease/ATP-binding-protein-CydD
MNKSRQKELTRWLKQQSVISQRWLNISRLLGFVSGILIIAQAWFMARILQHMIMENIPREALLLPFTLLVLTFVLRAWVVWLRERVGYHAGQHIRFAIRRQVLDRLQQAGPAWIQGKPAGSWATLVLEQIDDMHDYYARYLPQMALAVSVPLLIVVAIFPSNWAAALILLGTAPLIPLFMALVGMGAADANRRNFLALARLSGHFLDRLRGMETLRIFGRGEAEIESIRSASEDFRQRTMEVLRLAFLSSGILEFFTSLSIALVAVYFGFSYLGELDFGHYDTGVTLAAGFLALILAPEFFQPLRDLGTFYHAKAQAVGAADSLKTFMETPLAHPQRGETEIASTDPVTIEAEELFITSPEGKTLAGPLNFTLPAGQRAVLVGRSGSGKSSLLNALSGFLSYQGSLRINGIELRDLSPESWRKHLSWVGQNPQLPAATLRDNVLLARPDASEQELQAALDNAWVSEFLPLLPQGVDTPVGDQAARLSVGQAQRVAVARALLNPCSLLLLDEPAASLDAHSEQRVMEALNAASLRQTTLMVTHQLEDLADWDVIWVMQDGRIIEQGRYAELSVAGGPFATLLAHRQEEI

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Crispr_ID: NZ_CP027371_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027371_2

2198804-2198937

Orphan

Consensus_repeat	Method
TGCCTGATGCGACGCTGGCGCGTCTTATCAGGCCTACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP027371_2

>merge|NZ_CP027371|2|2198804-2198937|CRISPRCasFinder
TGCCTGATGCGACGCTGGCGCGTCTTATCAGGCCTACAAGACCCGAGCACAGAACCGTAGGCCGGATAAGGCGTTCACGCCGCATCCGGCATTCAGTGCCTGATGCGACGCTGACGCGTCTTATCAGGCCTACA

>NZ_CP027371|2|2|2198804-2198937|CRISPRCasFinder
TGCCTGATGCGACGCTGGCGCGTCTTATCAGGCCTACA	AGACCCGAGCACAGAACCGTAGGCCGGATAAGGCGTTCACGCCGCATCCGGCATTCAG
TGCCTGATGCGACGCTGACGCGTCTTATCAGGCCTACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027371.1\|WP_000479836.1\|2206169_2206649_-\|GDP-mannose-mannosyl-hydrolase	unknown	unknown	gnl\|CDD\|237966
NZ_CP027371.1\|WP_023486656.1\|2206651_2207617_-\|GDP-L-fucose-synthase	unknown	unknown	gnl\|CDD\|187550
NZ_CP027371.1\|WP_053276576.1\|2189364_2190243_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187564
NZ_CP027371.1\|WP_000079285.1\|2203510_2204947_-\|mannose-1-phosphate-guanyltransferase	unknown	unknown	gnl\|CDD\|185357
NZ_CP027371.1\|WP_047675362.1\|2209330_2210077_-\|colanic-acid-biosynthesis-glycosyltransferase-WcaE	unknown	unknown	gnl\|CDD\|182218
NZ_CP027371.1\|WP_053276575.1\|2187032_2188235_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340825
NZ_CP027371.1\|WP_053276581.1\|2197462_2198743_-\|colanic-acid-biosynthesis-pyruvyl-transferase-WcaK	unknown	unknown	gnl\|CDD\|188521
NZ_CP027371.1\|WP_053276578.1\|2191336_2192341_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371500
NZ_CP027371.1\|WP_000699706.1\|2204949_2206173_-\|colanic-acid-biosynthesis-fucosyltransferase-WcaI	unknown	unknown	gnl\|CDD\|188522
NZ_CP027371.1\|WP_001153581.1\|2208766_2209315_-\|colanic-acid-biosynthesis-acetyltransferase-WcaF	unknown	unknown	gnl\|CDD\|188523
NZ_CP027371.1\|WP_000048190.1\|2207619_2208741_-\|GDP-mannose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224014
NZ_CP027371.1\|WP_053276577.1\|2190245_2191283_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|275003
NZ_CP027371.1\|WP_053276586.1\|2188234_2189368_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|223458
NZ_CP027371.1\|WP_000183130.1\|2200498_2201893_-\|undecaprenyl-phosphate-glucose-phosphotransferase	unknown	unknown	gnl\|CDD\|182254
NZ_CP027371.1\|WP_001356294.1\|2201947_2203318_-\|phosphomannomutase-CpsG	unknown	unknown	gnl\|CDD\|185312
NZ_CP027371.1\|WP_000862683.1\|2196245_2197466_-\|colanic-acid-biosynthesis-glycosyltransferase-WcaL	unknown	unknown	gnl\|CDD\|188520
NZ_CP027371.1\|WP_053276579.1\|2192330_2193374_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP027371.1\|WP_053276582.1\|2199018_2200497_-\|M-antigen-undecaprenyl-disphosphate-flippase	unknown	unknown	gnl\|CDD\|236697
NZ_CP027371.1\|WP_053276580.1\|2193772_2194666_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalF	unknown	unknown	gnl\|CDD\|182252
NZ_CP027371.1\|WP_032219915.1\|2194840_2196235_-\|colanic-acid-biosynthesis-protein-WcaM	unknown	unknown	gnl\|CDD\|182253

Protein	Function_ID	Function_description	E-value
NZ_CP027371.1\|WP_000479836.1\|2206169_2206649_-\|GDP-mannose-mannosyl-hydrolase	gnl\|CDD\|237966	PRK15434, PRK15434, GDP-mannose mannosyl hydrolase.	1.30195e-118
NZ_CP027371.1\|WP_023486656.1\|2206651_2207617_-\|GDP-L-fucose-synthase	gnl\|CDD\|187550	cd05239, GDP_FS_SDR_e, GDP-fucose synthetase, extended (e) SDRs. GDP-fucose synthetase (aka 3, 5-epimerase-4-reductase) acts in the NADP-dependent synthesis of GDP-fucose from GDP-mannose. Two activities have been proposed for the same active site: epimerization and reduction. Proteins in this subgroup are extended SDRs, which have a characteristic active site tetrad and an NADP-binding motif, [AT]GXXGXXG, that is a close match to the archetypical form. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP027371.1\|WP_053276576.1\|2189364_2190243_-\|SDR-family-oxidoreductase	gnl\|CDD\|187564	cd05254, dTDP_HR_like_SDR_e, dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs. dTDP-6-deoxy-L-lyxo-4-hexulose reductase, an extended SDR, synthesizes dTDP-L-rhamnose from alpha-D-glucose-1-phosphate, providing the precursor of L-rhamnose, an essential cell wall component of many pathogenic bacteria. This subgroup has the characteristic active site tetrad and NADP-binding motif. This subgroup also contains human MAT2B, the regulatory subunit of methionine adenosyltransferase (MAT); MAT catalyzes S-adenosylmethionine synthesis. The human gene encoding MAT2B encodes two major splicing variants which are induced in human cell liver cancer and regulate HuR, an mRNA-binding protein which stabilizes the mRNA of several cyclins, to affect cell proliferation. Both MAT2B variants include this extended SDR domain. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.49519e-83
NZ_CP027371.1\|WP_000079285.1\|2203510_2204947_-\|mannose-1-phosphate-guanyltransferase	gnl\|CDD\|185357	PRK15460, cpsB, mannose-1-phosphate guanyltransferase; Provisional.	0
NZ_CP027371.1\|WP_047675362.1\|2209330_2210077_-\|colanic-acid-biosynthesis-glycosyltransferase-WcaE	gnl\|CDD\|182218	PRK10063, PRK10063, colanic acid biosynthesis glycosyltransferase WcaE.	1.40088e-178
NZ_CP027371.1\|WP_053276575.1\|2187032_2188235_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	1.74935e-103
NZ_CP027371.1\|WP_053276581.1\|2197462_2198743_-\|colanic-acid-biosynthesis-pyruvyl-transferase-WcaK	gnl\|CDD\|188521	TIGR04006, wcaK, colanic acid biosynthesis pyruvyl transferase WcaK. This gene is the pyruvyl transferase involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.	0
NZ_CP027371.1\|WP_053276578.1\|2191336_2192341_-\|hypothetical-protein	gnl\|CDD\|371500	pfam11380, Stealth_CR2, Stealth protein CR2, conserved region 2. Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.	1.40339e-52
NZ_CP027371.1\|WP_000699706.1\|2204949_2206173_-\|colanic-acid-biosynthesis-fucosyltransferase-WcaI	gnl\|CDD\|188522	TIGR04007, wcaI, colanic acid biosynthesis glycosyl transferase WcaI. This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.	0
NZ_CP027371.1\|WP_001153581.1\|2208766_2209315_-\|colanic-acid-biosynthesis-acetyltransferase-WcaF	gnl\|CDD\|188523	TIGR04008, WcaF, colanic acid biosynthesis acetyltransferase WcaF. This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species. This acetyltransferase is believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit).	1.0353e-131
NZ_CP027371.1\|WP_000048190.1\|2207619_2208741_-\|GDP-mannose-4,6-dehydratase	gnl\|CDD\|224014	COG1089, Gmd, GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane].	0
NZ_CP027371.1\|WP_053276577.1\|2190245_2191283_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|275003	TIGR04130, L-fucosamine_synthetase, UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase. The FnlA enzyme is the first step in the biosynthesis of UDP-FucNAc from UDP-GlcNAc in E. coli (along with FnlB and FnlC). The proteins identified by this model include FnlA homologs in the O-antigen clusters of O4, O25, O26, O29 (Shigella D11), O118, O145 and O172 serotype strains, all of which produce O-antigens containing FucNAc (or the further modified FucNAm). A homolog from Pseudomonas aerugiosa serotype O11, WbjB, also involved in the biosynthesis of UDP-FucNAc has been characterized and is now believed to carry out both the initial 4,6-dehydratase reaction and the subsequent epimerization of the resulting methyl group at C-5. A phylogenetic tree of related sequences shows a distinct clade of enzymes involved in the biosynthesis of UDP-QuiNAc (Qui=qinovosamine). This clade appears to be descendant from the common ancestor of the Pseudomonas and E. coli fucose-biosynthesis enzymes. It has been hypothesized that the first step in the biosynthesis of these two compounds may be the same, and thus that these enzymes all have the same function. At present, lacking sufficient confirmation of this, the current model trusted cutoff only covers the tree segment surrounding the E. coli genes. The clades containing the Pseudomonas and QuiNAc biosynthesis enzymes score above the noise cutoff. Immediately below the noise cutoff are enzymes involved in the biosynthesis of UDP-RhaNAc (Rha=rhamnose), which again may or may not produce the same product.	0
NZ_CP027371.1\|WP_053276586.1\|2188234_2189368_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	6.86455e-132
NZ_CP027371.1\|WP_000183130.1\|2200498_2201893_-\|undecaprenyl-phosphate-glucose-phosphotransferase	gnl\|CDD\|182254	PRK10124, PRK10124, putative UDP-glucose lipid carrier transferase; Provisional.	0
NZ_CP027371.1\|WP_001356294.1\|2201947_2203318_-\|phosphomannomutase-CpsG	gnl\|CDD\|185312	PRK15414, PRK15414, phosphomannomutase.	0
NZ_CP027371.1\|WP_000862683.1\|2196245_2197466_-\|colanic-acid-biosynthesis-glycosyltransferase-WcaL	gnl\|CDD\|188520	TIGR04005, wcaL, colanic acid biosynthesis glycosyltransferase WcaL. This gene is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species.	0
NZ_CP027371.1\|WP_053276579.1\|2192330_2193374_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.02155e-28
NZ_CP027371.1\|WP_053276582.1\|2199018_2200497_-\|M-antigen-undecaprenyl-disphosphate-flippase	gnl\|CDD\|236697	PRK10459, PRK10459, MOP flippase family protein.	0
NZ_CP027371.1\|WP_053276580.1\|2193772_2194666_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalF	gnl\|CDD\|182252	PRK10122, PRK10122, UTP--glucose-1-phosphate uridylyltransferase GalF.	0
NZ_CP027371.1\|WP_032219915.1\|2194840_2196235_-\|colanic-acid-biosynthesis-protein-WcaM	gnl\|CDD\|182253	PRK10123, wcaM, putative colanic acid biosynthesis protein; Provisional.	0

>NZ_CP027371.1|WP_053276581.1|2197462_2198743_-|colanic-acid-biosynthesis-pyruvyl-transferase-WcaK
MKLLILGNHTCGNRGDSAILRGLLDAINILNPQAEVDVMSRYPVSSSWLLNRPVMGDPLFLQMKQHNSAAGVVGRVKKVLRRRYQHQVLLSRVTDTGKLRNIAIAQGFTDFVRMLSGYDAIIQVGGSFFVDLYGVPQFEHALCTFMAKKPLFMIGHSVGPFQDEQFNQLANYVFGHCDALILRESVSLDLMKRSNITTAKVEHGVDTAWLVDHHTEDFTASYAVQHWLDVAAQQKTVAITLRELAPFDKRLGTTQQAYEKAFAGVVNRILDEGYQVIALSTCTGIDSYNKDDRMVALNLRQHISDPARYHVVMDELNDLEMGKILGACKLTVGTRLHSAIISMNFATPAIAINYEHKSAGIMQQLGLPEMAIDIRHLLDGSLQAMVADTLGQLPALNARLNEAVSRERQTGMQMVQSVLERIGEAK
>NZ_CP027371.1|WP_000862683.1|2196245_2197466_-|colanic-acid-biosynthesis-glycosyltransferase-WcaL
MKVGFFLLKFPLSSETFVLNQITAFIDMGFEVEIVALQKGDTQNTHAAWTKYNLAARTRWLQDEPTGKVAKLRHRASQTLRGIHRKNTWQALNLKRYGAESRNLILSAICGQVATPFYADVFIAHFGPAGVTAAKLRELGVIRGKIATIFHGIDISSREVLNHYTPEYQQLFRRGDLMLPISDLWAGRLQKMGCPREKIAVSRMGVDMTRFSPRPVKAPATPLEIISVARLTEKKGLHVAIEACRQLKEQGVAFRYRILGIGPWERRLRTLIEQYQLEDVVEMPGFKPSHEVKAMLDDADVFLLPSVTGADGDMEGIPVALMEAMAVGIPVVSTLHSGIPELVEADKSGWLVPENDARALAQRLAAFSQLDTDELAPVVKRAREKVEHDFNQQVINRELASLLQAL
>NZ_CP027371.1|WP_032219915.1|2194840_2196235_-|colanic-acid-biosynthesis-protein-WcaM
MPFKKLSRRTFLTASSALAFLHTPFARALPARQSVNINDYNPHDWIASFKQAFGEGQTVVVPAGLVCDNINTGIFISAGKTLHILGSLRGNGRGRFVLQDGSQVTGGEGGSMHNITLDVRGSDCTIKGLTMSGFGPVTQIYIGGKNKRVMRNLTIDNLTVSHANYAILRQGFHNQLIGANITNCKFSDLQGDAIEWNVAINDRDILISDHVIERINCTNGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKHFVIRNIKARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVITGKYLSIPQNFRVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKPQHLFMRNIKVMQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNERGQSSVDIDRINHHIVNVEKINFRLPERRE
>NZ_CP027371.1|WP_053276580.1|2193772_2194666_-|UTP--glucose-1-phosphate-uridylyltransferase-GalF
MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSEIMAVGRYVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNLKEGAKFRKGIEKLLSE
>NZ_CP027371.1|WP_053276579.1|2192330_2193374_-|glycosyltransferase-family-4-protein
MKIAFVGYNPGKIGGIEAFSRNMKNDIFPESEFVYEYDEAGTFKVDNCVPLLKRNLFNRVLNRLTNGNYTKSKIKKKLKEKKYDIIILNSPKYLDVSPDLCRTILVQHTTLDNWWKSKYNFGSNRNLAKLVKKVGKVVALSEMEGQVIKNFFRVEANKIRVINFSAGIPFLYGKKEPGKNLIMLARFQNEIKRIDLVIEAMDDLPDYTLNVYGDGKDRDYLIELSKHKKNVKIHSSITDKTSVLDKNNIYVLSSEYEGYPVSVIEAISRKLPVVARNTFYSASELVKDNGILLDKTWSKDEFCNAVRSCYENYEQYSNNSESYFYKYDITTIKNNWVSLVQELNYAQ
>NZ_CP027371.1|WP_053276578.1|2191336_2192341_-|hypothetical-protein
MRNDIDVVITWVDGNEPDWIKEYTYYKGCEPGRFRDIGVLKYIFRSLEKNMPWVRKIHFVTNGQYPTWLNLEHPKIYFHAHKDFFIYKDALPVFNSNAIELNFANIPDLSERFILFNDDMLVLKQVKEERFFDNGLPVDYCKLSYPRKGRLYKWLKPQNYLACELINNNYLYLKNTRVNQINKKNLYNKDYNLSTNISNFIFSIFRKVKWFEVYHHPQPHLKSTWLDKTSELRNAVVRNTIYTKFRAKTDVSHYLYRYQNLLNNKFTPRQYNDHYSIYVKNVNEFNKNIKKYFSNTFLCICEDENMGDTEFIKLRRILIKELEIMFPNKCSYEL
>NZ_CP027371.1|WP_053276577.1|2190245_2191283_-|polysaccharide-biosynthesis-protein
MFKSKVLLITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRKFYRSEKLKFYIGDVRDYQSISNAMRGVDYVYHAAALKQVPSCEFYPLEAVKTNVLGTENVLEAAINHSVKRVVCLSTDKAVYPINAMGISKAMMEKVIVAKGRNLSESNTVICCTRYGNVMASRGSVIPLFIRQAVNGQPITITDPNMTRFMMTLDDAVDLVLHAFKNGKSGDTFVQKAPAATIDILVKSLLSFLNKEDHPITVIGSRHGEKQFEALCSREEMLVAEDQGRYYRIPADNRDLNYSKYFEVGEKNLHLIQDYNSNNTEQLDVMGMKNLLRKLDFMREIEAGNIVIPEGV
>NZ_CP027371.1|WP_053276576.1|2189364_2190243_-|SDR-family-oxidoreductase
MKVLILGASGMLGYSLYANMSEYHEFEVFGTVRDIAGKEHYYNKPKGYIIKNVNILDLDKVKQIVAELKPDVVINCIGLIKQLSISKKYTSAITINALLPHQLAEICSSYEAKLIHFSTDCVFDGKKGNYKEDDLPTATDLYGKTKHMGEVYYGGHITLRTSIIGHELISSISLVEWFLNQEKEVKGFTKAIFSGLPTAYIAKLLAEKIIPNKSLSGLYHLSTFPINKYDLLTKISKVYDKNINIYKSDEVIIDRSLNSEKLRSEIGFVPPDWDELIEYMNADFKKWYTLCR
>NZ_CP027371.1|WP_053276586.1|2188234_2189368_-|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MNKKMKVATIVGTRPEIIRLSRIISRLDECTEHTLIHTGQNYDYELNQIFFNDLNIRAPNIFLECAGDTPAETIANVISKSDQLFEKLKPEALLILGDTNSALSAISAKRRKIPIFHMEAGNRCFDLRVPEEINRKIVDHIADINLPYSSIAREHLLREGLNPDLVIKTGSPMDEVLNFYASKIDASLSLQKMNVEENKYFLVSVHREENVDSDVNINNFVVLLNTLAKKYSLPIIVSTHPRTRKKIDSLDLKFSPLVQLMKPLGFSDYVKLQQHAKVVLSDSGTITEESSILNFPAINIREAHERPEGFEEASVMFTGMNIDRILQVIAILDQQPKGEKRILRKVYDYEAPNVSEKIVRIIHSYTDYVNRVVWKKY
>NZ_CP027371.1|WP_053276575.1|2187032_2188235_-|glycosyltransferase-family-4-protein
MHLALIIDDYLPDSTRVASKMFHELACAFVNGGHRVTVITPYYGRGNRLKKNHLDGVEVWYFKNPRIKDVGKIKRAFAETVLSLNAWIAIKHEPEIKNFDAVIYYSPSIFFGPLVRKIKEKSKCYAYQILRDMFPQWSVDAGLIRAGSLIEKYFRFFEKINYSQADYIGLMSQKNVELFNSKYNFCATGVLHNWARFECISYEPKYKKCLGLNDKVIFLYGGNIGHAQDMGNLLRLVRNMLPYDKAHFLFVGQGDEVELVNSLVKQWKLENLTYLPPLTQSEFKVLLSEVDVGLFSLAKNHTAHNFPGKILGYMVNSIPILGSVNDGNDLMPLINDANAGMVYVNGDDEHLFQAALTLLNDKSIRNNMGKCALALLRKEFDVEGVVIEIINKINGFYEKN
>NZ_CP027371.1|WP_053276582.1|2199018_2200497_-|M-antigen-undecaprenyl-disphosphate-flippase
MSLREKTISGAKWSAIATVIIIGLGLVQMTVLARIINNHQFGLLTVSLVIIALADTLSDFGIANSIIQRKEISHLELTTLYWLNVGLGIVVCVAVFLLSDLIGDVLNNPDLAPLIKTLSLAFVVIPHGQQFRALMQKELEFNKIGMIETSAVLAGFTFTVVSAHFWPLAMTAILGYLVNSAVRTLLFGYFGRKIYRPGLHFSLASVAPNLRFGAWLTADSIINYLNTNLSTLVLARILGAGVAGGYNLAYNVAVVPPMKLNPIITRVLFPAFAKIQDDTEKLRVNFYKLLSVVGIINFPALLGLMVVSNNFVPLVFGEKWNSIIPVLQLLCIVGLLRSVGNPIGSLLMAKARVDISFKFNVFKTFLFIPAIVIGGQMAGAIGVTLGFLLVQIINTILSYFVMIKPVLGSSYRQYILSLWLPFYLSLPTLVVSYALGIVLKGQLALGMLLAVQIAAGVLAFVVMIVLSRHPLMVEVKRQFCRSEKMKMLLRAG
>NZ_CP027371.1|WP_000183130.1|2200498_2201893_-|undecaprenyl-phosphate-glucose-phosphotransferase
MTNLKKRERAKTNASLISMVQRFSDITIMFAGLWLVCEVSGLSFLYMHLLVALITLVVFQMLGGITDFYRSWRGVRAATEFALLLQNWTLSVIFSAGLVAFNNDFDTQLKIWLAWYGLTSIGLVVCRSCIRIGAGWLRNHGYNKRMVAVAGDLAAGQMLMESFRNQPWLGFEVVGVYHDPKPGGVSNDWAGNLQQLVEDAKAGKIHNVYIAMQMCDGARVKKLVHQLADTTCSVLLIPDVFTFNILHSRLEEMNGVPVVPLYDTPLSGVNRLLKRAEDIVLATLILLLISPVLCCIALAVKLSSPGPVIFRQTRYGMDGKPIKVWKFRSMKVMENDKVVTQATQNDPRVTKVGNFLRRTSLDELPQFINVLTGGMSIVGPRPHAVAHNEQYRQLIEGYMLRHKVKPGITGWAQINGWRGETDTLEKMEKRVEFDLEYIREWSVWFDIKIVFLTVFKGFVNKAAY
>NZ_CP027371.1|WP_001356294.1|2201947_2203318_-|phosphomannomutase-CpsG
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKEKTLGELVRDRMVAFPASGEINSKLAQPAEAINRVEQHFSREALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE
>NZ_CP027371.1|WP_000079285.1|2203510_2204947_-|mannose-1-phosphate-guanyltransferase
MAQSKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVVICNEQHRFIVAEQLRQLNKLTENIILEPAGRNTAPAIALAALAAKRHSPESDPLMLVLAADHVIADEDAFRAAVRNAMPYAEAGKLVTFGIVPDLPETGYGYIRRGEVSAGEQDTVAFEVAQFVEKPNLETAQAYVASGEYYWNSGMFLFRAGRYLEELKKYRPDILDACEKAMSAVDPDLDFIRVDEEAFLACPEESVDYAVMERTADAVVVPMDAGWSDVGSWSSLWEISAHTAEGNVCHGDVINHKTENSYVYAESGLVTTVGVKDLVVVQTKDAVLIADRNAVQDVKKVVEQIKADGRHEHRVHREVYRPWGKYDSIDAGDRYQVKRITVKPGEGLSVQMHHHRAEHWVVVAGTAKVTIDGDIKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFADRYGRV
>NZ_CP027371.1|WP_000699706.1|2204949_2206173_-|colanic-acid-biosynthesis-fucosyltransferase-WcaI
MKILVYGINYSPELTGIGKYTGEMVEWLAAQGHEVRVITAPPYYPQWQVGENYSAWRYKREEGAATVWRCPLYVPKQPSTLKRLLHLGSFAVSSFFPLMAQRRWKPDRIIGVVPTLFCTPGMRLLAKLSGARTVLHIQDYEVDAMLGLGLAGKGKGGKVAQLATAFERSGLHNVDNVSTISRSMMNKAIEKGVAADNIIFFPNWSEIARFQHVADADVDALRNQLGLPDNKKIILYSGNIGEKQGLENVIEAADRLRDEPLIFAIVGQGGGKARLEKMAQQRGLRNMQFFPLQSYDALPALLKMGDCHLVVQKRGAADAVLPSKLTNILAVGGNAVITAEAHTELGQLCETFPGIAVCVEPESVEALVAGIRQALLLPKHNTVAREYAERTLDKENVLRQFINDIRG
>NZ_CP027371.1|WP_000479836.1|2206169_2206649_-|GDP-mannose-mannosyl-hydrolase
MFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRTNRPAQGYWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTHYVVLGFRFRVAEEELLLPDEQHDDYRWLTPDALLASDNVHANSRAYFLAEKRAGVPGL
>NZ_CP027371.1|WP_023486656.1|2206651_2207617_-|GDP-L-fucose-synthase
MSKQRVFIAGHRGMVGSAIKRQLEQRGDVELVLRTRDELNLLDSRAVHDFFASESIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKLLFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRDYRSVMPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGSGTPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDASKPDGTPRKLLDVTRLHQLGWYHEISLEAGLASTYQWFLENQDRFRG
>NZ_CP027371.1|WP_000048190.1|2207619_2208741_-|GDP-mannose-4,6-dehydratase
MSKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLHYGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANIAQGLESCLYLGNMDSLRDWGHAKDYVKMQWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFEGTGVEEKGIVVSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSEMVANDLEAAKKHSLLKSHGYDVAIALES
>NZ_CP027371.1|WP_001153581.1|2208766_2209315_-|colanic-acid-biosynthesis-acetyltransferase-WcaF
MQDLSGFSVPKGFRGGNAIKVQLWWAVQATLFAWSPQVLYRWRAFLLRLFGAKIGKNVVIRPSVKITYPWKLTLGDYAWVGDEVNLYTLGEITIGAHSVISQKSYLCTGSHDHASQHFTINATPIVIGEKCWLATDVFVAPGVTIGDGTVVGARSSVFKSLPANVVCRGNPAVVIRERVETE
>NZ_CP027371.1|WP_047675362.1|2209330_2210077_-|colanic-acid-biosynthesis-glycosyltransferase-WcaE
MLLSIITVAFRNLEGIVKTHASLAHLAQADDISFEWIVVDGGSNDGTREYLENLNGIYNLRFVSEPDNGIYDAMNKGIAMAQGKFALFLNSGDIFHQDAANFVRNLKVQKVNVMITGDALLDFGDGHKIKRSAKPGWYIYHSLPASHQAIFFPVSGLKKWRYDLEYKVSSDYALAAKMYKAGYAFKKLNGLVSEFSMGGVSTTNNMELCADAKKVQRQILHVPGFWAELSWHLRQRTTSKTKALYNKS

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Crispr_ID: NZ_CP027371_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027371_3

2900229-2900806

TypeI-E

I-E

Consensus_repeat	Method
CGGTTTATCCCCGCTGGCGCGGGGAACAC	CRT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	PILER-CR
CGGTTTATCCCCGCTGGCGCGGGGAACAC	CRISPRCasFinder

9 spacers

cas2,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NZ_CP027371_3

>merge|NZ_CP027371|3|2900229-2900806|CRT,PILER-CR,CRISPRCasFinder
GGGTGTTCTACCGCAGGGGCGGGGAATTCTAAGTGATATCCATCATCGCATCCAGTGCGCCCGGTTTATCCCCGCTGGCGCGGGGAACACTGCAAAACAAAACTGTATTGATCGCGTTTTGTCGGTTTATCCCCGCTGGCGCGGGGAACACGAAATGGCAGTTCTGGCCGCTTTTGATTATGGCGGTTTATCCCCGCTGGCGCGGGGAACACTAATTTTCGATTAACCAAATAGCCCGTGAGGGCGGTTTATCCCCGCTGGCGCGGGGAACACTGCATACCGTGCCAGCGCCAGTGCGGCGCGGCCGGTTTATCCCCGCTGGCGCGGGGAACACGGACGTGTGCCGGAGATTTTGAACCGCAGTCACGGTTTATCCCCGCTGGCGCGGGGAACACTGAATCTAAATGTTTTCCAATCTATTTTTTTGCGGTTTATCCCCGCTGGCGCGGGGAACACTTTATCGTCGCATGAATCGCGGTATCCATATTCGGTTTATCCCCGCTGGCGCGGGGAACACGTCCATCATTGCCTTGTTGATATACACAACGCCGGTTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027371|3|2|2900229-2900806|CRT
GGGTGTTCTACCGCAGGGGCGGGGAATTC	TAAGTGATATCCATCATCGCATCCAGTGCGCC
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGCAAAACAAAACTGTATTGATCGCGTTTTGT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GAAATGGCAGTTCTGGCCGCTTTTGATTATGG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TAATTTTCGATTAACCAAATAGCCCGTGAGGG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGCATACCGTGCCAGCGCCAGTGCGGCGCGGC
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GGACGTGTGCCGGAGATTTTGAACCGCAGTCA
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGAATCTAAATGTTTTCCAATCTATTTTTTTG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TTTATCGTCGCATGAATCGCGGTATCCATATT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GTCCATCATTGCCTTGTTGATATACACAACGC
CGGTTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027371|3|2|2900290-2900806|PILER-CR
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGCAAAACAAAACTGTATTGATCGCGTTTTGT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GAAATGGCAGTTCTGGCCGCTTTTGATTATGG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TAATTTTCGATTAACCAAATAGCCCGTGAGGG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGCATACCGTGCCAGCGCCAGTGCGGCGCGGC
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GGACGTGTGCCGGAGATTTTGAACCGCAGTCA
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGAATCTAAATGTTTTCCAATCTATTTTTTTG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TTTATCGTCGCATGAATCGCGGTATCCATATT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GTCCATCATTGCCTTGTTGATATACACAACGC
CGGTTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027371|3|3|2900290-2900806|CRISPRCasFinder
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGCAAAACAAAACTGTATTGATCGCGTTTTGT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GAAATGGCAGTTCTGGCCGCTTTTGATTATGG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TAATTTTCGATTAACCAAATAGCCCGTGAGGG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGCATACCGTGCCAGCGCCAGTGCGGCGCGGC
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GGACGTGTGCCGGAGATTTTGAACCGCAGTCA
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TGAATCTAAATGTTTTCCAATCTATTTTTTTG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TTTATCGTCGCATGAATCGCGGTATCCATATT
CGGTTTATCCCCGCTGGCGCGGGGAACAC	GTCCATCATTGCCTTGTTGATATACACAACGC
CGGTTTATCCCCGCTGGCGCGGGGAACAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027371.1\|WP_106879151.1\|2901195_2902116_-\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NZ_CP027371.1\|WP_000246138.1\|2894369_2895080_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NZ_CP027371.1\|WP_000568924.1\|2892844_2893894_-\|tRNA-pseudouridine(13)-synthase-TruD	unknown	unknown	gnl\|CDD\|234884
NZ_CP027371.1\|WP_000085051.1\|2902744_2903491_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl\|CDD\|187776
NZ_CP027371.1\|WP_001173673.1\|2895976_2896582_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|179661
NZ_CP027371.1\|WP_000206443.1\|2903501_2904557_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	cd09646_cas7_CAS-I-E	gnl\|CDD\|273843
NZ_CP027371.1\|WP_001084096.1\|2905101_2906664_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09669_cas8e_CAS-I-E	gnl\|CDD\|274192
NZ_CP027371.1\|WP_000517476.1\|2895098_2895410_-\|cell-division-protein-FtsB	unknown	unknown	gnl\|CDD\|179156
NZ_CP027371.1\|WP_001233971.1\|2906761_2909461_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP027371.1\|WP_001219242.1\|2893890_2894370_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|178851
NZ_CP027371.1\|WP_000490431.1\|2899170_2900208_+\|alkaline-phosphatase-isozyme-conversion-aminopeptidase	unknown	unknown	gnl\|CDD\|182299
NZ_CP027371.1\|WP_000281455.1\|2902112_2902763_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	cd09664_cas6e_CAS-I-E	gnl\|CDD\|273869
NZ_CP027371.1\|WP_000029329.1\|2904568_2905105_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl\|CDD\|274193
NZ_CP027371.1\|WP_001246104.1\|2895603_2895927_-\|DUF3561-family-protein	unknown	unknown	gnl\|CDD\|371891
NZ_CP027371.1\|WP_001090347.1\|2896581_2898009_-\|sulfate-adenylyltransferase-subunit-CysN	unknown	unknown	gnl\|CDD\|235349
NZ_CP027371.1\|WP_000039841.1\|2910070_2910805_-\|phosphoadenosine-phosphosulfate-reductase	unknown	unknown	gnl\|CDD\|234997
NZ_CP027371.1\|WP_001349984.1\|2892102_2892864_-\|5'/3'-nucleotidase-SurE	unknown	unknown	gnl\|CDD\|234732
NZ_CP027371.1\|WP_000063176.1\|2900902_2901196_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	cd09648_cas2_CAS-I-E	gnl\|CDD\|236930
NZ_CP027371.1\|WP_000372108.1\|2898010_2898919_-\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_CP027371.1\|WP_000956458.1\|2909653_2909806_-\|type-I-toxin-antitoxin-system-Hok-family-toxin	unknown	unknown	gnl\|CDD\|366840

Protein	Function_ID	Function_description	E-value
NZ_CP027371.1\|WP_106879151.1\|2901195_2902116_-\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	2.1996e-155
NZ_CP027371.1\|WP_000246138.1\|2894369_2895080_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	3.26939e-121
NZ_CP027371.1\|WP_000568924.1\|2892844_2893894_-\|tRNA-pseudouridine(13)-synthase-TruD	gnl\|CDD\|234884	PRK00984, truD, tRNA pseudouridine synthase D; Reviewed.	0
NZ_CP027371.1\|WP_000085051.1\|2902744_2903491_-\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187776	cd09645, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	5.83917e-49
NZ_CP027371.1\|WP_001173673.1\|2895976_2896582_-\|adenylyl-sulfate-kinase	gnl\|CDD\|179661	PRK03846, PRK03846, adenylylsulfate kinase; Provisional.	7.34447e-148
NZ_CP027371.1\|WP_000206443.1\|2903501_2904557_-\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|273843	TIGR01869, CRISPR_system_Cascade_subunit_CasC, CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum and is part of the Ecoli subtype of CRISPR/Cas locis. It is designated Cse4, for CRISPR/Cas Subtype Ecoli protein 4.	5.21697e-155
NZ_CP027371.1\|WP_001084096.1\|2905101_2906664_-\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|274192	TIGR02547, CRISPR_system_Cascade_subunit_CasA, CRISPR type I-E/ECOLI-associated protein CasA/Cse1. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family, represented by CT1972 from Chlorobium tepidum, is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It is designated Cse1.	0
NZ_CP027371.1\|WP_000517476.1\|2895098_2895410_-\|cell-division-protein-FtsB	gnl\|CDD\|179156	PRK00888, ftsB, cell division protein FtsB; Reviewed.	5.55235e-62
NZ_CP027371.1\|WP_001233971.1\|2906761_2909461_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.4506e-175
NZ_CP027371.1\|WP_001219242.1\|2893890_2894370_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|178851	PRK00084, ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed.	1.56248e-104
NZ_CP027371.1\|WP_000490431.1\|2899170_2900208_+\|alkaline-phosphatase-isozyme-conversion-aminopeptidase	gnl\|CDD\|182299	PRK10199, PRK10199, alkaline phosphatase isozyme conversion aminopeptidase; Provisional.	0
NZ_CP027371.1\|WP_000281455.1\|2902112_2902763_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|273869	TIGR01907, CRISPR_system_Cascade_subunit_CasE, CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family, represented by CT1974 from Chlorobium tepidum, is found in the Ecoli subtype of CRISPR/Cas regions and is designated Cse3 (CRISPR/Cas Subtype Ecoli protein 3). The representative of this family from Thermus thermophilus HB8 (TTHB192) has been crystallized and found to have a structure consisting of two domains with opposing parallel beta-sheets known as a beta-sheet platform. This structure is similar to those found in the Sex-lethal protein and poly(A)-binding protein. This structure is consistent with an RNA-binding function.	1.33324e-91
NZ_CP027371.1\|WP_000029329.1\|2904568_2905105_-\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|274193	TIGR02548, CRISPR_system_Cascade_subunit_CasB, CRISPR type I-E/ECOLI-associated protein CasB/Cse2. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It was designated Cse2 originally, and renamed CasB based on its characterization in the CASCADE complex.	1.12087e-29
NZ_CP027371.1\|WP_001246104.1\|2895603_2895927_-\|DUF3561-family-protein	gnl\|CDD\|371891	pfam12084, DUF3561, Protein of unknown function (DUF3561). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.	1.22003e-52
NZ_CP027371.1\|WP_001090347.1\|2896581_2898009_-\|sulfate-adenylyltransferase-subunit-CysN	gnl\|CDD\|235349	PRK05124, cysN, sulfate adenylyltransferase subunit 1; Provisional.	0
NZ_CP027371.1\|WP_000039841.1\|2910070_2910805_-\|phosphoadenosine-phosphosulfate-reductase	gnl\|CDD\|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	4.50395e-137
NZ_CP027371.1\|WP_001349984.1\|2892102_2892864_-\|5'/3'-nucleotidase-SurE	gnl\|CDD\|234732	PRK00346, surE, 5'(3')-nucleotidase/polyphosphatase; Provisional.	2.58692e-149
NZ_CP027371.1\|WP_000063176.1\|2900902_2901196_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	2.35543e-65
NZ_CP027371.1\|WP_000372108.1\|2898010_2898919_-\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP027371.1\|WP_000956458.1\|2909653_2909806_-\|type-I-toxin-antitoxin-system-Hok-family-toxin	gnl\|CDD\|366840	pfam01848, HOK_GEF, Hok/gef family.	8.32243e-12

>NZ_CP027371.1|WP_000490431.1|2899170_2900208_+|alkaline-phosphatase-isozyme-conversion-aminopeptidase
MFSALRHRTAALALGVCFILPVHASSPKPGDFANTQARHIATFFPGRMTGTPAEMLSADYIRQQFQQMGYRSDIRTFNSRYIYTARDNRKSWHNVTGSTVIAAHEGKAPQQIIIMAHLDTYAPLSDADADANLGGLTLQGMDDNAAGLGVMLELAERLKNTPTEYGIRFVATSGEEEGKLGAENLLKRMSDTEKKNTLLVINLDNLIVGDKLYFNSGVKTPEAVRKLTRDRALAMARSHGIAATTNPGLNKNYPKGTGCCNDAEIFDKAGIAVLSVEATNWNLGNKDGYQQRAKTAAFPAGNSWHDVRLDNQQHIDKALPGRIERRCRDVMRIMLPLVKELAKTS
>NZ_CP027371.1|WP_000372108.1|2898010_2898919_-|sulfate-adenylyltransferase-subunit-CysD
MDQIRLTHLRQLEAESIHIIREVAAEFSNPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYEFRDRTAKAYGCELLVHKNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMIDDNRIDLQPGEVIKKRMVRFRTLGCWPLTGAVESNAQTLPEIIEEMLVSTTSERQGRVIDRDQAGSMELKKRQGYF
>NZ_CP027371.1|WP_001090347.1|2896581_2898009_-|sulfate-adenylyltransferase-subunit-CysN
MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYSEETFTRIREDYLTFAEQLPGNLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPKNEAAVASSEFSAFELELNALVRRHFPHWGARDLLGDK
>NZ_CP027371.1|WP_001173673.1|2895976_2896582_-|adenylyl-sulfate-kinase
MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
>NZ_CP027371.1|WP_001246104.1|2895603_2895927_-|DUF3561-family-protein
MRNSHNITLTNNDSLTEDEETTWSLPGAVVGFISWLFALAMPMLIYGSNTLFFFIYTWPFFLALMPVAVVVGIALHSLMDGKLRYSIVFTLVTVGIMFGALFMWLLG
>NZ_CP027371.1|WP_000517476.1|2895098_2895410_-|cell-division-protein-FtsB
MGKLTLLLLAILVWLQYSLWFGKNGIHDYTRVNDDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTRPGETFYRLVPDASKRAQSAGQNNR
>NZ_CP027371.1|WP_000246138.1|2894369_2895080_-|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
>NZ_CP027371.1|WP_001219242.1|2893890_2894370_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
>NZ_CP027371.1|WP_000568924.1|2892844_2893894_-|tRNA-pseudouridine(13)-synthase-TruD
MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
>NZ_CP027371.1|WP_001349984.1|2892102_2892864_-|5'/3'-nucleotidase-SurE
MRILLSNDDGVHAPGIQTLAKTLREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGSRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPDTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
>NZ_CP027371.1|WP_000063176.1|2900902_2901196_-|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MSMVVVVTENVPPRLRGRLAIWLLEVRAGVYVGDTSKRIREMIWQQITQLAGCGNVVMAWATNTESGFEFQTWGENRRIPVDLDGLRLVSFLPVDNQ
>NZ_CP027371.1|WP_106879151.1|2901195_2902116_-|type-I-E-CRISPR-associated-endonuclease-Cas1
MTFVPLSPIPLKDRTSMIFLQYGQIDVLHGAFVLINKTGIRTHIPVGSVACIMLEPGTRVSHAAVHLAATVGTLLVWVGEAGVRVYSSGQPGGARPDKLLYQAKLALTEDLRLKVVRKMYELRFREPPPARRSVEQLRGIEGSRVRQTYALLAKQYGVKWNGRKYDPKDWEKGDVVNRCISAATSCLYGISEAAVLAAGYAPAIGFIHSGKPLSFVYDIADIIKFDSVVPKAFEIAARQPAEPDKEVRLACRDIFRSTKLTGKLIPLIEEVLAAGEIEPPQPAPDMLPPAIPEPETLGDSGHRGRG
>NZ_CP027371.1|WP_000281455.1|2902112_2902763_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRITLHTGQLSPAQLLHLVDRGEYVMHQWLWDLFPGGKERQFLYRREELQGAFRFFVLSQERPAESETFTIECRPFVSELRTGQSLCFNLRANPTICKAGKRHDLLMEAKRQVKGQAEGRDIWLHQQQAALDWLAAQGERSGFTLLDTSVDAYRQQQLRRENTRQLIQFSSVDYTGMLTVTDPGLFLQRLSQGYGKSRAFGCGLMLIKPGAEA
>NZ_CP027371.1|WP_000085051.1|2902744_2903491_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSQYLIFQLHGPMASWGVDAPGEVRHTHELPSRSALLGLLAAGVGIRRDDTERLNAFNRHYSLVVCASRNPRWARDYHTIQMPKEVRKARYFSRREELSDPDLLSAIISRRDYYTDAWWMVAVATTADAPYSLEQLQDGLRHPVFPLYLGRKSHPLALPLAPLLLEGNACDALCNAYQQYQDHFHKLKVSLPKLQDECWWEGEHDGLVASKILRRRDVPLNRQQWLFGERTINQGPWLSKEEPCTSQE
>NZ_CP027371.1|WP_000206443.1|2903501_2904557_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTTFIQLHLLTAYPAANLNRDDTGAPKTVVLGGATRLRVSSQSLKRAWRTSALFEQALAGHIGIRSGRIAREAATILIEKGIEEKKAIEWAAKIADYLGKAKNDKKPKDPLTNAETEQLVHISPAEFDAVKALAHQLAEEKRAPKEEDLALLRKDRMAVDIAMFGRMLANKPEFNVEAACQVAHAFGVSETIVEDDFFTAVDDLRQASEDAGAGHLGETGFGSALFYTYICIDKDLLVENLGGDEALANQTIRAFTEAALKVSPTGKQNSFASRAYASWAMAEKGTEQPRSLAAAFYEPINGTRQLEVAVQRITTLRENMNTVYEQKTECASFDVMNKQGSMKDVLDFICA
>NZ_CP027371.1|WP_000029329.1|2904568_2905105_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MSIVKEEHKATLRKWHEELQEKRGERASLRRSTTVNDVCLTDGFRLFLKNRQIKWQDEPEWRITALALIAAVSANVKAIDERQPFAAQLAAVMSKGRFTRLSAVKTPDELLRQLRRAVRLLNGSVNLDSLAEGVFRWCQESDDLLNHHRRQQRPTEFIRIRWALEYYQAGDADNEQNQ
>NZ_CP027371.1|WP_001084096.1|2905101_2906664_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MNSFSLLTTPWLPVRFKDGTTGKLAPVDLADENVVDIAAPRADLQGAAWQFLLGLLQTSFAPKNHGRWDDIWQDGLEAEKLREALLSLEHAFQFGADSPSFMQDFEALKGDKVQVASLLPEIPGAQTTKFNKDHFIKRGVTEHVCPHCSALALFSLQLNAPSGGKGYRTGLRGGGPMTTLIELQEYQGNQQTPLWRKLWPNVMPQDEADLPLPKKFDDLVFPWLGPTRTSELAGAVVTHDQVNKLQAYWGMPRRIRIDFNTTTVGNCDICGEQSDALLSLMTTKNYGANYAMWQHPLTPYRIPLKEGGEFYSVKPQPGGLIWRDWLGLIETGKSENNTELPALVVKLFNASSLKQAKVGLWGFGYDFDNMKARCWYEHHFPLLLKKKEGQIPKLRLAAQTASRILSLLRSALKEAWFSDPKGARGDFSFVDIDFWNKTQHRFLRLVRQIEEGQDADELLGKWQKEIWLFARQDFDERVFTNPYEPVDLKRVMTARKKYFTTSAEKQSAKAAREKKQEAAE
>NZ_CP027371.1|WP_001233971.1|2906761_2909461_-|CRISPR-associated-helicase/endonuclease-Cas3
MRKYPLSLLKDKNIVTFFDFWGKTRRGEKEGGDDYHLLCWHSLDVAAMGYLMVKRNCFGLADYFRQLGISDKEQAAQFFAWLLCWHDIGKFARSFQQLYLPPELKIQEGARKNYEKISHSTLGYWLWNHYLSECQELLPSSSLSPRKLRRVIEMWMPVTTGHHGRPPDRMDELDNFLPEDKAAARDFLLAIKALFPRIEIPAFWDDDEGIELIKHLSWYISATVVLADWTGSSTRFFPRVAQAMDIKHYWQKALVQAQNALTVFPPKAETAPFTGINTLFPFIENPTPLQQKVLDLDISQPGPQLFILEDVTGAGKTEAALILAHRLIAAGKAQGLFFGLPTMATANAMYDRLVKTWLSFYSPESRPSLVLAHSARTLMDRFNESLWSGDLIGSEEPDEQAFSQGCAAWFADSNKKALLAEIGVGTLDQAMMAVMPFKHNNLRLLGLSNKILLADEIHACDAYMSCILEGLIERQARGGNSVILLSATLSQQQRDKLVAAFARGAEGQQEAPLLGKDDYPWLTHVTKTDVHSHRVATRKEVERSVSVGWLHSEQECIARIESAVSQGKCIAWIRNSVDDAIQVYRQLLARGVIPASSLSLFHSRFAFSDRQRIETETLARFGKYCSLQRASQVIVCTQVIEQSVDIDLDEMISDLAPVDLLIQRAGRLQRHIRDINGQLKRDGKDERSPPELLILAPVWDDSPGDEWFGSAMRNSAFVYPDHGRIWLTQRVLREQGAIQMPHAARLLIESVYGEDVVMPEGFARSEQEQVGKYYCDRAMAKKFVLNFRPGYAANINDYLPEKLSTRLAEESVSLWLATCIDGVVKPYATGAHAWEMSVVRVRRSWWKKHRDEFSLLEGEAFRLWCIEQRQDPEMANVILVNDDESCGYSATEGLIGKVG
>NZ_CP027371.1|WP_000956458.1|2909653_2909806_-|type-I-toxin-antitoxin-system-Hok-family-toxin
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK
>NZ_CP027371.1|WP_000039841.1|2910070_2910805_-|phosphoadenosine-phosphosulfate-reductase
MSKLDLNALNELPKVDRILALAETNAELEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQIHPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNAQTWFAGLRREQSGSRANLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG

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Crispr_ID: NZ_CP027371_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027371_4

2926505-2926899

Unclear

I-E

Consensus_repeat	Method
CGGTTTATCCCCGCTGGCGCGGGGAACAC	CRISPRCasFinder
CGGTTTATCCCCGCTGGCGCGGGGAAC	CRT
CGGTTTATCCCCGCTGGCGCGGGGAAC	PILER-CR

6 spacers

The CRISPR arrays of NZ_CP027371_4

>merge|NZ_CP027371|4|2926505-2926899|CRISPRCasFinder,CRT,PILER-CR
TGGTTTATCCCCGCTGGCGCGGGGAACTCAACATCGGAAACGGCTTCGCGGCGGCGGCGTCCGGTTTATCCCCGCTGGCGCGGGGAGCTCTACGTGAAGAATATTTGCAACACCCGCAAGAACGGTTTATCCCCGCTGGCGCGGGGAACACAGAGAACGCGGCACTGATCCACATCGCGTACGCGGTTTATCCCCGCTGGCGCGGGGAACACTCAGCCAAGTTTTGCGCCCGGCGCAAGTAGCGCGGTTTATCCCCGCTGGCGCGGGGAACACAATGGCGCGCACATATTCAACTGATGGCGTAACGGTTTATCCCCGCTGGCGCGGGGAACACCAAGCCGGGATTTGCTTTCGGCCAGTTGGTCTCGGTTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027371|4|4|2926505-2926899|CRISPRCasFinder
TGGTTTATCCCCGCTGGCGCGGGGAACTC	AACATCGGAAACGGCTTCGCGGCGGCGGCGTC
CGGTTTATCCCCGCTGGCGCGGGGAGCTC	TACGTGAAGAATATTTGCAACACCCGCAAGAA
CGGTTTATCCCCGCTGGCGCGGGGAACAC	AGAGAACGCGGCACTGATCCACATCGCGTACG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	TCAGCCAAGTTTTGCGCCCGGCGCAAGTAGCG
CGGTTTATCCCCGCTGGCGCGGGGAACAC	AATGGCGCGCACATATTCAACTGATGGCGTAA
CGGTTTATCCCCGCTGGCGCGGGGAACAC	CAAGCCGGGATTTGCTTTCGGCCAGTTGGTCT
CGGTTTATCCCCGCTGGCGCGGGGAACAC

>NZ_CP027371|4|3|2926505-2926897|CRT
TGGTTTATCCCCGCTGGCGCGGGGAAC	TCAACATCGGAAACGGCTTCGCGGCGGCGGCGTC
CGGTTTATCCCCGCTGGCGCGGGGAGC	TCTACGTGAAGAATATTTGCAACACCCGCAAGAA
CGGTTTATCCCCGCTGGCGCGGGGAAC	ACAGAGAACGCGGCACTGATCCACATCGCGTACG
CGGTTTATCCCCGCTGGCGCGGGGAAC	ACTCAGCCAAGTTTTGCGCCCGGCGCAAGTAGCG
CGGTTTATCCCCGCTGGCGCGGGGAAC	ACAATGGCGCGCACATATTCAACTGATGGCGTAA
CGGTTTATCCCCGCTGGCGCGGGGAAC	ACCAAGCCGGGATTTGCTTTCGGCCAGTTGGTCT
CGGTTTATCCCCGCTGGCGCGGGGAAC

>NZ_CP027371|4|3|2926506-2926897|PILER-CR
GGTTTATCCCCGCTGGCGCGGGGAACT	CAACATCGGAAACGGCTTCGCGGCGGCGGCGTCC
GGTTTATCCCCGCTGGCGCGGGGAGCT	CTACGTGAAGAATATTTGCAACACCCGCAAGAAC
GGTTTATCCCCGCTGGCGCGGGGAACA	CAGAGAACGCGGCACTGATCCACATCGCGTACGC
GGTTTATCCCCGCTGGCGCGGGGAACA	CTCAGCCAAGTTTTGCGCCCGGCGCAAGTAGCGC
GGTTTATCCCCGCTGGCGCGGGGAACA	CAATGGCGCGCACATATTCAACTGATGGCGTAAC
GGTTTATCCCCGCTGGCGCGGGGAACA	CCAAGCCGGGATTTGCTTTCGGCCAGTTGGTCTC
GGTTTATCCCCGCTGGCGCGGGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027371.1\|WP_000581937.1\|2933582_2933831_-\|type-II-toxin-antitoxin-system-antitoxin-MazE	unknown	unknown	gnl\|CDD\|182082
NZ_CP027371.1\|WP_001071648.1\|2932385_2933177_-\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|236569
NZ_CP027371.1\|WP_106879153.1\|2930520_2932158_-\|CTP-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|235437
NZ_CP027371.1\|WP_001299097.1\|2917410_2918271_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP027371.1\|WP_106879152.1\|2921979_2922765_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
NZ_CP027371.1\|WP_001130266.1\|2916687_2917263_+\|glycerol-3-phosphate-responsive-antiterminator	unknown	unknown	gnl\|CDD\|224865
NZ_CP027371.1\|WP_001164567.1\|2923083_2924361_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP027371.1\|WP_000226815.1\|2933908_2936143_-\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|182797
NZ_CP027371.1\|WP_001349983.1\|2915148_2916420_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|182194
NZ_CP027371.1\|WP_000036723.1\|2929134_2930433_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP027371.1\|WP_001199973.1\|2927238_2927910_-\|7-carboxy-7-deazaguanine-synthase-QueE	unknown	unknown	gnl\|CDD\|275126
NZ_CP027371.1\|WP_001288227.1\|2928048_2928189_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP027371.1\|WP_000109367.1\|2916410_2916671_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|225289
NZ_CP027371.1\|WP_000254745.1\|2933247_2933583_-\|endoribonuclease-MazF	unknown	unknown	gnl\|CDD\|182138
NZ_CP027371.1\|WP_000046790.1\|2936190_2937492_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|237291
NZ_CP027371.1\|WP_000059311.1\|2920455_2921910_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP027371.1\|WP_001098105.1\|2919024_2920362_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP027371.1\|WP_000039749.1\|2924387_2925866_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|212662
NZ_CP027371.1\|WP_001268452.1\|2928202_2929075_+\|YgcG-family-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP027371.1\|WP_001324445.1\|2918267_2919047_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997

Protein	Function_ID	Function_description	E-value
NZ_CP027371.1\|WP_000581937.1\|2933582_2933831_-\|type-II-toxin-antitoxin-system-antitoxin-MazE	gnl\|CDD\|182082	PRK09798, PRK09798, MazF-MazE toxin-antitoxin system antitoxin MazE.	6.19513e-48
NZ_CP027371.1\|WP_001071648.1\|2932385_2933177_-\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|236569	PRK09562, mazG, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	8.97718e-160
NZ_CP027371.1\|WP_106879153.1\|2930520_2932158_-\|CTP-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NZ_CP027371.1\|WP_001299097.1\|2917410_2918271_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	7.42017e-90
NZ_CP027371.1\|WP_106879152.1\|2921979_2922765_-\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.04476e-139
NZ_CP027371.1\|WP_001130266.1\|2916687_2917263_+\|glycerol-3-phosphate-responsive-antiterminator	gnl\|CDD\|224865	COG1954, GlpP, Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription].	5.83077e-88
NZ_CP027371.1\|WP_001164567.1\|2923083_2924361_+\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	3.44047e-29
NZ_CP027371.1\|WP_000226815.1\|2933908_2936143_-\|GTP-pyrophosphokinase	gnl\|CDD\|182797	PRK10872, relA, (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional.	0
NZ_CP027371.1\|WP_001349983.1\|2915148_2916420_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|182194	PRK10015, PRK10015, oxidoreductase; Provisional.	3.72406e-126
NZ_CP027371.1\|WP_000036723.1\|2929134_2930433_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP027371.1\|WP_001199973.1\|2927238_2927910_-\|7-carboxy-7-deazaguanine-synthase-QueE	gnl\|CDD\|275126	TIGR04322, organic_radical_activating_enzyme, putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE. Members of this radical SAM domain protein family appear to be the E. coli form of the queuosine biosynthesis protein QueE. QueE is involved in making preQ0 (7-cyano-7-deazaquanine), a precursor of both the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. Members occur in species that lack known forms of QueE but usually are not found in queuosine biosynthesis operons. Members of this family tend to form bi-directional best hit matches to members of known (TIGR03365) and putative (TIGR03963) QueE families from other lineages.	3.98248e-155
NZ_CP027371.1\|WP_001268452.1\|2928202_2929075_+\|YgcG-family-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	1.00793e-100
NZ_CP027371.1\|WP_000109367.1\|2916410_2916671_+\|ferredoxin-family-protein	gnl\|CDD\|225289	COG2440, FixX, Ferredoxin-like protein [Energy production and conversion].	8.55479e-42
NZ_CP027371.1\|WP_000254745.1\|2933247_2933583_-\|endoribonuclease-MazF	gnl\|CDD\|182138	PRK09907, PRK09907, endoribonuclease MazF.	2.42227e-74
NZ_CP027371.1\|WP_000046790.1\|2936190_2937492_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|237291	PRK13168, rumA, 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD.	0
NZ_CP027371.1\|WP_000059311.1\|2920455_2921910_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	9.1825e-83
NZ_CP027371.1\|WP_001098105.1\|2919024_2920362_-\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.74708e-50
NZ_CP027371.1\|WP_000039749.1\|2924387_2925866_+\|sugar-kinase	gnl\|CDD\|212662	cd07779, FGGY_ygcE_like, uncharacterized ygcE-like proteins. This subfamily consists of uncharacterized hypothetical bacterial proteins with similarity to Escherichia coli sugar kinase ygcE , whose functional roles are not yet clear. Escherichia coli ygcE is recognized by this model, but is not present in the alignment as it contains a deletion relative to other members of the group. These proteins belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	5.32002e-110
NZ_CP027371.1\|WP_001324445.1\|2918267_2919047_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	7.46503e-62

>NZ_CP027371.1|WP_000039749.1|2924387_2925866_+|sugar-kinase
MSKKYIIGIDGGSQSTKVVMYDLEGNVVCEGKGLLQPMHTPYADTAEHPDDDLWASLCFAGHDLMSQFAGNKEDIVGIGLGSIRCCRALLKADGTPAAPLISWQDARVTRPYEHTNPDVAYVTSFSGYLTHRLTGEFKDNIANYFGQWPVDYKSRAWSEDAAVMDKFNIPRHMLFDVQMPGTVLGHITPQAALATHFPAGLPVVCTTSDKPVEALGAGLLDDETAVISLGTYIALMMNGKALPKDPVAYWPIMSSIPQTLLYEGYGIRKGMWTVSWLRDMLGESLIQDARAQDLSPEDLLNKKASSVPPGCNGLMTVLDWLTNPWEPYKRGIMIGFDSSMDYAWIYRSILESVALTLKNNYDNMCNEMNHFAKHVIITGGGSNSDLFMQIFADVFNLPARRNAINGCASLGAAINTAVGLGLYPDYATAVDKMVRVKDIFIPIESNAKRYDAMNKGIFKDLTKHTDVILKKSYEVMHGELGNVDSIQSWSNA
>NZ_CP027371.1|WP_001164567.1|2923083_2924361_+|MFS-transporter
MQHNSYRRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTILMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFAPDDSASLKTVIIIYSVVYILLGILCWFFVSDNNNLRSANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASYMGIVINKIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALLVTNSNPQSVAMGIGLILLLGFTCYASRGLYWACPGEARTPSYIMGTTVGICSVIGFLPDVFVYPIIGHWQDTLPAAEAYRNMWLMGMAALAMVIVFTFLLFQKIRTADSAPAMASSK
>NZ_CP027371.1|WP_106879152.1|2921979_2922765_-|SDR-family-oxidoreductase
MSIESLNAFSMDFFSLKGKTAIVTGGNSGLGQAFAMALAKAGANIFIPSFVKDNGETKEMIEKQGVEVDFMQVDITAEGAPQKIIAACCERFGTVDILVNNAGICKLNKVLDFGRADWDPMIDVNLTAAFELSYEAAKIMIPQKSGKIINICSLFSYLGGQWSPAYSATKHALAGFTKAYCDELGQYNIQVNGIAPGYYATDITLATRSNPETNQRVLDHIPANRWGDTQDLMGAAVFLASPASNYVNGHLLVVDDGYLVR
>NZ_CP027371.1|WP_000059311.1|2920455_2921910_-|FAD-binding-oxidoreductase
MSLSRAAIVDQLKEIVGADRVITDETVLKKNSIDRFRKFPDIHGIYTLPIPAAVVKLGSTEQVSRVLNFMNAHKINGVPRTGASATEGGLETVVENSVVLDGSAMNQIINIDIENMQATAQCGVPLEVLENALREKGYTTGHSPQSKPLAQMGGLVATRSIGQFSTLYGAIEDMVVGLEAVLADGTVTRIKNVPRRAAGPDIRHIIIGNEGALCYITEVTVKIFKFTPENNLFYGYILEDMKTGFNILREVMVEGYRPSIARLYDAEDGTQHFTHFADGKCVLIFMAEGNPRIAKATGEGIAEIVARYPQCQRVDSKLIETWFNNLNWGPDKVAAERVQILKTGNMGFTTEVSGCWSCIHEIYESVINRIRTEFPHADDITMLGGHSSHSYQNGTNMYFVYDYNLVDCKPEEEIDKYHNPLNKIICEETIRLGGSMVHHHGIGKHRVHWSKLEHGSAWALLEGLKKQFDPNGIMNTGTIYPIEK
>NZ_CP027371.1|WP_001098105.1|2919024_2920362_-|MFS-transporter
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTLFSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLATVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV
>NZ_CP027371.1|WP_001324445.1|2918267_2919047_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNILLAFKAEPDAGMLAEKEWQAAAQGKSGPDISLLRSLLGADEQAAAALLLAQRKNGTPMSLTALSMGDERALHWLRYLMALGFEEAVLLETAADLRFAPEFVARHIAEWQHQNPLDLIITGCQSSEGQNGQTPFLLAEMLGWPCFTQVERFTLDALFITLEQRTEHGLRCCRVRLPAVIAVRQCGEVALPVPGMRQRMAAGKAEIIRKTVAAEMPAMQCLQLARAEQRRGATLIDGQTVAEKAQKLWRDYLRQRMQP
>NZ_CP027371.1|WP_001299097.1|2917410_2918271_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MNIAIVTINQENAAIASWLAAQDFSGCTLAHWQIEPQPVVAEQVLDALVEQWQRTPADVVLFPPGTFGDELSTRLAWRLHGASICQVTSLDIPTVSVRKSHWGNALTATLQTEKRPLCLSLARQAGAAKNATLPSGMQQLNIVPGALPDWLVSTEDLKNVTRDPLAEARRVLVVGQGGEADNQEIAMLAEKLGAEVGYSRARVMNGGVDAEKVIGISGHLLAPEVCIVVGASGAAALMAGVRNSKFVVAINHDASAAVFSQADVGVVDDWKVVLEALVTNIHADCQ
>NZ_CP027371.1|WP_001130266.1|2916687_2917263_+|glycerol-3-phosphate-responsive-antiterminator
MPLLHLLRQNPVIAAVKDNASLQLAIDSECQFISVLYGNICTISNIVKKIKNAGKYAFIHVDLLEGASNKEVVIQFLKLVTEADGIISTKASMLKAARAEGFFCIHRLFIVDSISFHNIDKQVAQSNPDCIEILPGCMPKVLGWVTEKIRQPLIAGGLVCDEEDARNAINAGVVALSTTNTGVWTLAKKLL
>NZ_CP027371.1|WP_000109367.1|2916410_2916671_+|ferredoxin-family-protein
MSVAHNLWRVADAPHIVPADSVERQMVQRLINACPAGLFSLTPEGDLRVDYHGCLECGTCRLLCDESTLQQWRYPPSGFGITYRFG
>NZ_CP027371.1|WP_001349983.1|2915148_2916420_+|FAD-dependent-oxidoreductase
MEDDCDIIIIGAGIAGTACALRCARAGLSVLLLERAEIPGSKNLSGGRLYTHALAELLPQFHLTAPLERRITHESLSLLTPDGATTFSSLQPGGESWSVLRARFDPWLVAEAEKEGVECIPGATVDALYEENGRVCGVICGDDILRARYVVLAEGANSVLAERHGLVTRPAGEAMALGIKEVLSLETSAIEERFHLENNEGAALLFSGGICDDLPGGAFLYTNQQTLSLGIVCPLSSLTQSRVPASELLTRFKAHPAVRPLIKNTESLEYGAHLVPEGGLHSMPVQYAGNGWLLVGDALRSCVNTGISVRGMDMALTGAQAAAQTLISACQHREPQNLFALYHHNVERSLLWDILQRYQHVPALLQRPGWYRAWPALMQDISRDLWDQGDKPVPPLRQLFWRHLRRHGLWHLAGDVIRSLRCL
>NZ_CP027371.1|WP_001199973.1|2927238_2927910_-|7-carboxy-7-deazaguanine-synthase-QueE
MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWEKLEDREVSLFSILAKTKESDKWGAASSEDLLAVIGRQGYTARHVVITGGEPCIHDLLPLTDLLEKNGFSCQIETSGTHEVRCTPNTWVTVSPKLNMRGGYEVLSQALERANEIKHPVGRVRDIEALDELLATLTDDKPRVIALQPISQKDDATRLCIETCIARNWRLSMQTHKYLNIA
>NZ_CP027371.1|WP_001288227.1|2928048_2928189_+|hypothetical-protein
MSEENKENGFNHVKTFTKIIFIFSVLVFNDNESKITDAAVNLFIQI
>NZ_CP027371.1|WP_001268452.1|2928202_2929075_+|YgcG-family-protein
MRYFILMFTFVCSFVAAQPTIVPQLQQQVTDLTSSLNSQEKKELTHKLESIFNNTQVQIAVLIVPTTKDETIEQYATRVFDNWRLGDAKRNDGILIIVAWSDRTVRIQVGYGLEEKVTDALAGDIIRSNMIPAFKQQKFAQGLELAINALNSQLTSQHQYPTNPSESESASSSDHYYFAIFWVFAVMFFPFWFFHQGSNFCRACKSGVCISAIYLLDLFLFSDKIFSIAVFSFFFTFTIFMVFTCLCVLQKRASGKSYHSDNSGSGGGSSGGGFSGGGGSSGGGGASGRW
>NZ_CP027371.1|WP_000036723.1|2929134_2930433_-|phosphopyruvate-hydratase
MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
>NZ_CP027371.1|WP_106879153.1|2930520_2932158_-|CTP-synthase-(glutamine-hydrolyzing)
MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANSTEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQSQLVDDSLVRQLYNAPTIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAASEFQKRQAK
>NZ_CP027371.1|WP_001071648.1|2932385_2933177_-|nucleoside-triphosphate-pyrophosphohydrolase
MNQIDRLLTIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVFADSSAENSSEVLARWEQIKTEERAQKAQHSALDDIPRSLPALMRAQKIQKRCANVGFDWTTLGPVVDKVYEEIDEVMYEARQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRFREVERIVAARGLEMTGVDLETMEEVWQQVKRQEIDL
>NZ_CP027371.1|WP_000254745.1|2933247_2933583_-|endoribonuclease-MazF
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
>NZ_CP027371.1|WP_000581937.1|2933582_2933831_-|type-II-toxin-antitoxin-system-antitoxin-MazE
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKEVW
>NZ_CP027371.1|WP_000226815.1|2933908_2936143_-|GTP-pyrophosphokinase
MVAVRSAHINKAGEFDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMAAIRQLKATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEIQIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKEAEKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKPSAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRLHGS
>NZ_CP027371.1|WP_000046790.1|2936190_2937492_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MAQFYSAKRRTTTRQIITVSVNDLDSFGQGVARHNGKALFIPGLLPQENAEVTVTEDKKQYARAKVVRRLSDSPERETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKHEVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKAGSSDIVDVKQCPILVPQLEALLPKVRACLGSLQAIRHLGHVELVQATSGTLMILRHTAPLSSADREKLERFSHSEGLDLYLAPDSEILETVSGEMPWYDSNGLRLTFSPRDFIQVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFTLPLATQAASVVGVEGVPALVEKGQQNARLNGLQNVTFYHENLEEDVTKQPWAKNGFDKVLLDPARAGAAGVMQQIIKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAMLDMFPHTGHLESMVLFSRVK

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Crispr_ID: NZ_CP027371_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP027371_5

4844527-4844642

Orphan

Consensus_repeat	Method
GATAAGACGCGCCAGCGTCGCATCAGGCGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP027371_5

>merge|NZ_CP027371|5|4844527-4844642|CRISPRCasFinder
GATAAGACGCGCCAGCGTCGCATCAGGCGTTGAATGCCGGATGCGCTTTGCTTATCCGGCCTACAAAAACACAGCGCGTAGGCCAGATAAGACGCGTCAGCGTCGCATCAGGCGTT

>NZ_CP027371|5|5|4844527-4844642|CRISPRCasFinder
GATAAGACGCGCCAGCGTCGCATCAGGCGTT	GAATGCCGGATGCGCTTTGCTTATCCGGCCTACAAAAACACAGCGCGTAGGCCA
GATAAGACGCGTCAGCGTCGCATCAGGCGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP027371.1\|WP_000951795.1\|4846174_4847875_-\|ribulokinase	unknown	unknown	gnl\|CDD\|235221
NZ_CP027371.1\|WP_106879205.1\|4852311_4853295_-\|thiamine-ABC-transporter-substrate-binding-subunit	unknown	unknown	gnl\|CDD\|236883
NZ_CP027371.1\|WP_000035638.1\|4841340_4843692_-\|DNA-polymerase-II	unknown	unknown	gnl\|CDD\|235595
NZ_CP027371.1\|WP_001297366.1\|4853458_4855114_-\|HTH-type-transcriptional-regulator-SgrR	unknown	unknown	gnl\|CDD\|184188
NZ_CP027371.1\|WP_000637846.1\|4855435_4856614_+\|sugar-efflux-transporter-SetA	unknown	unknown	gnl\|CDD\|129977
NZ_CP027371.1\|WP_000241283.1\|4831729_4832719_-\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NZ_CP027371.1\|WP_000888642.1\|4843766_4844462_-\|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl\|CDD\|236181
NZ_CP027371.1\|WP_000746151.1\|4834057_4836412_-\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158
NZ_CP027371.1\|WP_000525182.1\|4837598_4838258_-\|bifunctional-tRNA-pseudouridine(32)-synthase/23S-rRNA-pseudouridine(746)-synthase-RluA	unknown	unknown	gnl\|CDD\|236659
NZ_CP027371.1\|WP_001300811.1\|4848213_4849092_+\|arabinose-operon-transcriptional-regulator-AraC	unknown	unknown	gnl\|CDD\|236717
NZ_CP027371.1\|WP_001148403.1\|4849177_4849942_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP027371.1\|WP_001200573.1\|4836666_4837482_+\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NZ_CP027371.1\|WP_001065381.1\|4830911_4831733_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP027371.1\|WP_000235716.1\|4850725_4852336_-\|thiamine/thiamine-pyrophosphate-ABC-transporter-permease-ThiP	unknown	unknown	gnl\|CDD\|181853
NZ_CP027371.1\|WP_000151734.1\|4844661_4846164_-\|L-arabinose-isomerase	unknown	unknown	gnl\|CDD\|179503
NZ_CP027371.1\|WP_000610901.1\|4830531_4830909_-\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP027371.1\|WP_001248770.1\|4855202_4855334_+\|glucose-uptake-inhibitor-SgrT	unknown	unknown	gnl\|CDD\|374203
NZ_CP027371.1\|WP_000916280.1\|4850043_4850742_-\|thiamine-ABC-transporter-ATP-binding-protein-ThiQ	unknown	unknown	gnl\|CDD\|182716
NZ_CP027371.1\|WP_000800457.1\|4832718_4834005_-\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NZ_CP027371.1\|WP_106879204.1\|4838269_4841176_-\|RNA-polymerase-associated-protein-RapA	unknown	unknown	gnl\|CDD\|235319

Protein	Function_ID	Function_description	E-value
NZ_CP027371.1\|WP_000951795.1\|4846174_4847875_-\|ribulokinase	gnl\|CDD\|235221	PRK04123, PRK04123, ribulokinase; Provisional.	0
NZ_CP027371.1\|WP_106879205.1\|4852311_4853295_-\|thiamine-ABC-transporter-substrate-binding-subunit	gnl\|CDD\|236883	PRK11205, tbpA, thiamine transporter substrate binding subunit; Provisional.	0
NZ_CP027371.1\|WP_000035638.1\|4841340_4843692_-\|DNA-polymerase-II	gnl\|CDD\|235595	PRK05762, PRK05762, DNA polymerase II; Reviewed.	0
NZ_CP027371.1\|WP_001297366.1\|4853458_4855114_-\|HTH-type-transcriptional-regulator-SgrR	gnl\|CDD\|184188	PRK13626, PRK13626, HTH-type transcriptional regulator SgrR.	0
NZ_CP027371.1\|WP_000637846.1\|4855435_4856614_+\|sugar-efflux-transporter-SetA	gnl\|CDD\|129977	TIGR00899, Sugar_efflux_transporter_A, sugar efflux transporter. This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP027371.1\|WP_000241283.1\|4831729_4832719_-\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NZ_CP027371.1\|WP_000888642.1\|4843766_4844462_-\|L-ribulose-5-phosphate-4-epimerase	gnl\|CDD\|236181	PRK08193, araD, L-ribulose-5-phosphate 4-epimerase AraD.	1.31794e-177
NZ_CP027371.1\|WP_000746151.1\|4834057_4836412_-\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0
NZ_CP027371.1\|WP_000525182.1\|4837598_4838258_-\|bifunctional-tRNA-pseudouridine(32)-synthase/23S-rRNA-pseudouridine(746)-synthase-RluA	gnl\|CDD\|236659	PRK10158, PRK10158, bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA.	4.54332e-159
NZ_CP027371.1\|WP_001300811.1\|4848213_4849092_+\|arabinose-operon-transcriptional-regulator-AraC	gnl\|CDD\|236717	PRK10572, PRK10572, arabinose operon transcriptional regulator AraC.	0
NZ_CP027371.1\|WP_001148403.1\|4849177_4849942_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.87417e-49
NZ_CP027371.1\|WP_001200573.1\|4836666_4837482_+\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	1.09407e-169
NZ_CP027371.1\|WP_001065381.1\|4830911_4831733_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	2.76119e-148
NZ_CP027371.1\|WP_000235716.1\|4850725_4852336_-\|thiamine/thiamine-pyrophosphate-ABC-transporter-permease-ThiP	gnl\|CDD\|181853	PRK09433, thiP, thiamine transporter membrane protein; Reviewed.	0
NZ_CP027371.1\|WP_000151734.1\|4844661_4846164_-\|L-arabinose-isomerase	gnl\|CDD\|179503	PRK02929, PRK02929, L-arabinose isomerase; Provisional.	0
NZ_CP027371.1\|WP_000610901.1\|4830531_4830909_-\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	3.63315e-76
NZ_CP027371.1\|WP_001248770.1\|4855202_4855334_+\|glucose-uptake-inhibitor-SgrT	gnl\|CDD\|374203	pfam15894, SgrT, Inhibitor of glucose uptake transporter SgrT.	0.00206924
NZ_CP027371.1\|WP_000916280.1\|4850043_4850742_-\|thiamine-ABC-transporter-ATP-binding-protein-ThiQ	gnl\|CDD\|182716	PRK10771, thiQ, thiamine ABC transporter ATP-binding protein ThiQ.	5.43465e-163
NZ_CP027371.1\|WP_000800457.1\|4832718_4834005_-\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	0
NZ_CP027371.1\|WP_106879204.1\|4838269_4841176_-\|RNA-polymerase-associated-protein-RapA	gnl\|CDD\|235319	PRK04914, PRK04914, RNA polymerase-associated protein RapA.	0

>NZ_CP027371.1|WP_000888642.1|4843766_4844462_-|L-ribulose-5-phosphate-4-epimerase
MLEDLKRLVLEANLALPKHNLVTLTWGNVSAVDRERGVFVIKPSGVDYSVMTADDMVVVSIATGEVVEGTKKPSSDTPTHRLLYQAFPSIGGIVHTHSRHATIWAQAGQSIPATGTTHADYFYGTIPCTRKMTDAEINGEYEWETGNVIVETFEKQGIDAAQMPGVLVHSHGPFAWGKNAEDAVHNAIVLEEVAYMGIFCRQLAPQLPDMQQTLLDKHYLRKHGAKAYYGQ
>NZ_CP027371.1|WP_000035638.1|4841340_4843692_-|DNA-polymerase-II
MAQAGFILTRHWRDTPQGTEVSFWLATDNGPLQVTLAPQESVAFIPADQVPRAQHILQGEQGFRLTPLALKDFHRQPVYGLYCRAHRQLMNYEKRLREGGVTVYEADVRPPERYLMERFITSPVWVEGDIRNGAIVNARLKPHPDYRPPLKWVSIDIETTRHGELYCIGLEGCGQRIVYMLGPENGDASALDFELEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRIPLRLGRDNSELEWREHGFKNGVFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQELLGEGKSIDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPVDRHGGSVAAFGHLYFPRMHRAGYVAPNLGEVPPHASPGGYVMDSRPGLYDSVLVLDYKSLYPSIIRTFLIDPVGLVEGMAQPDPEHSTEGFLDAWFSREKHCLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGTTACRFFDPRLASSITMRGHQIMRQTKALIEAQGYDVIYGDTDSTFVWLKGAHSEEEAAKIGRVLVQHVNAWWAETLQKQRLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPLAQQFQQELYLRIFRNEPYQEYVRQTIDKLMAGELDARLVYRKRLRRPLSEYQRNVPPHVRAARLADEENQKRGRPLQYQNRGTIKYVWTTNGPEPLDYQRSPLDYEHYLTRQLQPVAEGILPFIEDNFATLMTGQLGLF
>NZ_CP027371.1|WP_106879204.1|4838269_4841176_-|RNA-polymerase-associated-protein-RapA
MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTSPTGRTIYDSVYNDLINYLASPDQTEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQVLAESIEEQDDDTNLIAFAMNLFDIIGINQDDRSDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
>NZ_CP027371.1|WP_000525182.1|4837598_4838258_-|bifunctional-tRNA-pseudouridine(32)-synthase/23S-rRNA-pseudouridine(746)-synthase-RluA
MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYVADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF
>NZ_CP027371.1|WP_001200573.1|4836666_4837482_+|co-chaperone-DjlA
MQYWGKIIGVAVALLMGGGFWGVVLGLLIGHMFDKARSRKMAWFANQRERQALFFATTFEVMGHLTKSKGRVTEADIHIASQLMDRMNLHGASRTAAQNAFRVGKSDNYPLREKMRQFRSVCFGRFDLIRMFLEIQIQAAFADGSLHPNERAVLYVIAEELGISRAQFDQFLRMMQGGAQFGGGYQQQSGGGNWQQAQRGPTLEDACNVLGVKPTDDATTIKRAYRKLMSEHHPDKLVAKGLPPEMMEMAKQKAQEIQQAYELIKQQKGFK
>NZ_CP027371.1|WP_000746151.1|4834057_4836412_-|LPS-assembly-protein-LptD
MKKRIPTLLATMIATALYSQQGLAADLASQCMLGVPSYDRPLVQGDTNDLPVTINADHAKGDYPDDAVFTGSVDIMQGNSRLQADEVQLHQKEAPGQPEPVRTVDALGNVHYDDNQVILKGPKGWANLNTKDTNVWEGDYQMVGRQGRGKADLMKQRGENRYTILDNGSFTSCLPGSDTWSVVGSEIIHDREEQVAEIWNARFKVGPVPIFYSPYLQLPVGDKRRSGFLIPNAKYTTTNYFEFYLPYYWNIAPNMDATITPHYMHRRGNIMWENEFRYLSQAGAGLMELDYLPSDKVYEDEHPNDDSSRRWLFYWNHSGVMDQVWRFNVDYTKVSDPSYFNDFDNKYGSSTDGYATQKFSVGYAVQNFNATVSTKQFQVFSEQNTSSYSAEPQLDVNYYQNDVGPFDTRIYGQAVHFVNTRDDMPEATRVHLEPTINLPLSNNWGSINTEAKLLATHYQQTNLDWYNSRNTTKLDESVNRVMPQFKVDGKMVFERDMEMLAPGYTQTLEPRAQYLYVPYRDQSDIYNYDSSLLQSDYSGLFRDRTYGGLDRIASANQVTTGVTSRIYDDAAVERFNISVGQIYYFTESRTGDDNITWENDDKTGSLVWAGDTYWRISERWGLRGGIQYDTRLDNVATSNSSIEYRRDEDRLVQLNYRYASPEYIQATLPKYYSTAEQYKNGISQVGAVASWPIADRWSIVGAYYYDTNANKQADSMLGVQYSSCCYAIRVGYERKLNGWDNDKQHAVYDNAIGFNIELRGLSSNYGLGTQEMLRSNILPYQNTL
>NZ_CP027371.1|WP_000800457.1|4832718_4834005_-|peptidylprolyl-isomerase-SurA
MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQLPDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLDQMRSRLAYDGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATPDIFDPAFRDALTRLNKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRASAYVKILSN
>NZ_CP027371.1|WP_000241283.1|4831729_4832719_-|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADTTLLTDRAAMLGLPLTLRPYSPNSPAQPQTTGTLTLLPVALRESVTAGQLGVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLDELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGEADVGSFITALNLAIKMIVNTQ
>NZ_CP027371.1|WP_001065381.1|4830911_4831733_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES
>NZ_CP027371.1|WP_000610901.1|4830531_4830909_-|Co2+/Mg2+-efflux-protein-ApaG
MINSPRVCIQVQSVYIEAQSSPDNERYVFAYTVTIRNLGRAPVQLLGRYWLITNGNGRETEVQGEGVVGVQPLIAPGEEYQYTSGAIIETPLGTMQGHYEMIDENGVPFSIDIPVFRLAVPTLIH
>NZ_CP027371.1|WP_000151734.1|4844661_4846164_-|L-arabinose-isomerase
MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVLKPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPLLQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGHWQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKRQNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSHMLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLGDRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHHTVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGFRR
>NZ_CP027371.1|WP_000951795.1|4846174_4847875_-|ribulokinase
MAIAIGLDFGSDSVRALAVDCASGEEIATSVEWYPRWQKGQFCDAPNNQFRHHPRDYIESMEAALKTVLAELSVEQRAAVVGIGVDTTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEAEEITRLCHAPGNVDYSRYIGGIYSSEWFWAKILHVTRQDTAVAQSAASWIELCDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELDPILNRHLPSPLFTDTWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDILIADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAQHPELKAQINASQKQLLPALTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPLLFGGLIAATAFGARAIMECFTDQGIAVNNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPRSEQAQRFEQLYRRYQQWAMSAEQHYLPTSAPAQAAQAVATL
>NZ_CP027371.1|WP_001300811.1|4848213_4849092_+|arabinose-operon-transcriptional-regulator-AraC
MAEAQNDPLLPGYSFNAHLVAGLTPIEANGYLDFFIDRPLGMKGYILNLTIRGQGVVKNQGREFVCRPGDILLFPPGEIHHYGRHPEAREWYHQWVYFRPRAYWHEWLNWPSIFANTGFFRPDEAHQPHFSDLFGQIINAGQGEGRYSELLAINLLEQLLLRRMEAINESLHPPMDNRVREACQYISDHLADSNFDIASVAQHVCLSPSRLSHLFRQQLGISVLSWREDQRISQAKLLLSTTRMPIATVGRNVGFDDQLYFSRVFKKCTGASPSEFRAGCEEKVNDVAVKLS
>NZ_CP027371.1|WP_001148403.1|4849177_4849942_+|DedA-family-protein
MQALLEHFITQSTVYSLMAVVLVAFLESLALVGLILPGTVLMAGLGALIGSGELSFWHAWLAGIVGCLLGDWISFWLGWRFKKPLHRWSFLKKNKALLDKTEHALHQHSMFTILVGRFVGPTRPLVPMVAGMLDLPVAKFITPNIIGCLLWPPFYFLPGILAGAAIDIPAGMQSGEFKWLLLATAVFLWVGGWLCWRLWRSGKATDRLSHYLSRGRLLWLTPLISAIGVVALVVLIRHPLMPVYIDILRKVVGV
>NZ_CP027371.1|WP_000916280.1|4850043_4850742_-|thiamine-ABC-transporter-ATP-binding-protein-ThiQ
MLKLTDITWLYHHLPMRFSLTVERGEQVAILGPSGAGKSTLLNLIAGFLTPASGSLTIDGVDHTTMPPSRRPVSMLFQENNLFSHLTVAQNIGLGLNPGLKLNAAQQEKMHAIARQMGIDNLMARLPGELSGGQRQRVALARCLVREQPILLLDEPFSALDPALRQEMLTLVSTSCQQQKMTLLMVSHSVEDAARIATRSVVVADGRIAWQGKTDELLSGKARASALLGITG
>NZ_CP027371.1|WP_000235716.1|4850725_4852336_-|thiamine/thiamine-pyrophosphate-ABC-transporter-permease-ThiP
MATRRQPLIPGWLIPGVSAATLVVAVALAAFLALWWNAPQGSWAAIWQDSYLWHVVRFSFWQAFLSALLSVIPAIFLARALYRRRFPGRLALLRLCAMTLILPVLVAVFGILSVYGRQGWLAALWQSLGLEWTFSPYGLQGILLAHVFFNLPMASRLLLQALENIPGEQRQLAAQLGMRSWHFFRFVEWPWLRRQIPPVAALIFMLCFASFATVLSLGGGPQATTIELAIYQALSYDYDPARAAMLALIQMVCCLGLVLLSQRLSKAIAPGTTLLQGWRDPDDRLHSRICDTVLIVLALLLLLPPLLAVIVDGVNRQLPEVLAQPVLWQALWTSLRIALAAGVLCVVLTMMLLWSSRELRARQKMLAGQALEMSGMLILAMPGIVLATGFFLLLNNTIGLPQSADGIVIFTNALMAIPYALKVLENPMRDITARYSMLCQSLGIEGWSRLKVVELRALKRPLAQALAFACVLSISDFGVVALFGNDDFRTLPFYLYQQIGSYRSQDGAVTALILLLLCFLLFTVIEKLPGRNVKTD
>NZ_CP027371.1|WP_106879205.1|4852311_4853295_-|thiamine-ABC-transporter-substrate-binding-subunit
MLKKCLPLLLLCTAPVFAKPVLTVYTYDSFAADWGPGPKIKKAFEADCNCELKLVALEDGVSLLNRLRMEGKNSKADVVLGLDNNLLDAASKTGLFAKSGVAADAINVPGGWNNDTFVPFDYGYFAFVYDKNKLKNPPQSLKELVESDQNWRVIYEDPRTSTPGLGLLLWMQKVYGDDAPQAWQKLAKKTVTVTKGWSEAYGLFLKGESDLVLSYTTSPAYHILEEKKDNYAAANFSEGHYLQVEVAARTAASKLPELAQKFLQFMVSPAFQNAIPTGNWMYPVANVTLPAGFEQLTKPATTLEFTPAKVAAQRQAWISEWQRAVSR
>NZ_CP027371.1|WP_001297366.1|4853458_4855114_-|HTH-type-transcriptional-regulator-SgrR
MPSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVGRGKRSRLTFLYTGLALQQQRAEDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRHILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEENGELEADIAHHWQQISPLHWRFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLPLLLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNTTNQLKIQAFDDFFGYRALIDEVNVWVLPEIADEPAGGLMLKGPQGEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVLSPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTIKSEKPAGLESLTLTFYQDHSEHRVIAGIMQQILASHQVTLEIKEISYDQWHEGEIESDIWLNSANFTLPLDFSLFAHLCEVPLLQHCIPIDWQADAARWRNGEMNLANWCQQLVASKAMVPLIHHWLIIQGQRSMRGLRMNTLGWFDFKSAWFAPPDP
>NZ_CP027371.1|WP_001248770.1|4855202_4855334_+|glucose-uptake-inhibitor-SgrT
MRQFYQHYFTATAKLCWLRWLSVPQRLTMLEGLMQWDDRNSES
>NZ_CP027371.1|WP_000637846.1|4855435_4856614_+|sugar-efflux-transporter-SetA
MIWIMTMARRMNGVYAAFMLVAFMMGVAGALQAPTLSLFLSREVGAQPFWIGLFYTVNAIAGIGVSLWLAKRSDSQGDRRKLIIFCCLMAIGNALLFAFNRHYLTLITCGVLLASLANTAMPQLFALAREYADNSAREVVMFSSVMRAQLSLAWVIGPPLAFMLALNYGFTVMFSIAAGIFTLSLVLIAFMLPSVARVELPSENALSMQGGWQDSNVRMLFVASTLMWTCNTMYIIDMPLWISSELGLPDKLAGFLMGTAAGLEIPAMILAGYYVKRYGKRRMMVIAVAAGVLFYTGLIFFHSRMALMTLQLFNAVFIGIVAGIGMLWFQDLMPGRAGAATTLFTNSISTGVILAGVIQGAIAQSWGHFAVYWVIAVISVVALFLTAKVKDV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP027371_3	3.1\|2900258\|32\|NZ_CP027371\|CRT	2900258-2900289	32	LC542972	Escherichia coli IOMTU792 plasmid pIOMTU792 DNA, complete sequence	246937-246968	3	0.906
NZ_CP027371_4	4.6\|2926839\|32\|NZ_CP027371\|CRISPRCasFinder	2926839-2926870	32	LR134281	Klebsiella aerogenes strain NCTC9793 genome assembly, plasmid: 6	1431-1462	4	0.875
NZ_CP027371_2	2.1\|2198842\|58\|NZ_CP027371\|CRISPRCasFinder	2198842-2198899	58	MT230312	Escherichia coli strain DH5alpha plasmid pESBL31, complete sequence	104-161	5	0.914
NZ_CP027371_4	4.3\|2926656\|32\|NZ_CP027371\|CRISPRCasFinder	2926656-2926687	32	MT361768	Ralstonia phage RPZH6, complete genome	23375-23406	5	0.844
NZ_CP027371_4	4.3\|2926656\|32\|NZ_CP027371\|CRISPRCasFinder	2926656-2926687	32	MT361768	Ralstonia phage RPZH6, complete genome	24213-24244	5	0.844
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_CP034578	Lactococcus lactis subsp. lactis strain UC08 plasmid pUC08E, complete sequence	2106-2137	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_AP017930	Lactobacillus sakei subsp. sakei DSM 20017 = JCM 1157 strain LT-13 plasmid pLs13-a, complete sequence	4021-4052	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_CP043525	Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_01, complete sequence	3312-3343	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_CP014889	Lactobacillus backii strain TMW 1.1991 plasmid pL11991-8, complete sequence	1082-1113	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NC_015860	Lactococcus lactis subsp. lactis plasmid pIL1, complete sequence	3081-3112	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_AP022342	Enterococcus faecium strain KUHS13 plasmid pKO1, complete sequence	143632-143663	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_CP044372	Klebsiella pneumoniae strain 2018C01-046 plasmid p2018C01-046-4, complete sequence	5474-5505	6	0.812
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_MG674581	Enterococcus faecium strain HL1 plasmid pHLSA, complete sequence	148696-148727	6	0.812
NZ_CP027371_3	3.8\|2900685\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900685-2900716	32	NZ_CP041426	Escherichia coli strain STEC388 plasmid pSTEC388_1, complete sequence	15256-15287	6	0.812
NZ_CP027371_4	4.3\|2926656\|32\|NZ_CP027371\|CRISPRCasFinder	2926656-2926687	32	MT740736	Ralstonia phage Eline, complete genome	499-530	6	0.812
NZ_CP027371_4	4.3\|2926656\|32\|NZ_CP027371\|CRISPRCasFinder	2926656-2926687	32	MT740739	Ralstonia phage Gerry, complete genome	48442-48473	6	0.812
NZ_CP027371_4	4.9\|2926654\|34\|NZ_CP027371\|CRT	2926654-2926687	34	MT361768	Ralstonia phage RPZH6, complete genome	23373-23406	6	0.824
NZ_CP027371_4	4.9\|2926654\|34\|NZ_CP027371\|CRT	2926654-2926687	34	MT361768	Ralstonia phage RPZH6, complete genome	24211-24244	6	0.824
NZ_CP027371_4	4.15\|2926655\|34\|NZ_CP027371\|PILER-CR	2926655-2926688	34	MT361768	Ralstonia phage RPZH6, complete genome	23373-23406	6	0.824
NZ_CP027371_4	4.15\|2926655\|34\|NZ_CP027371\|PILER-CR	2926655-2926688	34	MT361768	Ralstonia phage RPZH6, complete genome	24211-24244	6	0.824
NZ_CP027371_1	1.4\|878226\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878226-878257	32	NZ_CP032893	Enterobacter kobei strain WCHEK045523 plasmid p1_045523, complete sequence	14694-14725	7	0.781
NZ_CP027371_3	3.1\|2900258\|32\|NZ_CP027371\|CRT	2900258-2900289	32	NZ_CP015038	Burkholderia cenocepacia strain 895 plasmid pBcp895-1, complete sequence	112768-112799	7	0.781
NZ_CP027371_3	3.2\|2900319\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900319-2900350	32	NC_030948	Ralstonia phage RSP15 DNA, complete genome	100984-101015	7	0.781
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	CP022460	Shigella sonnei strain 2015C-3807 plasmid unnamed1, complete sequence	32099-32130	7	0.781
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NZ_CP015232	Epibacterium mobile F1926 plasmid unnamed2, complete sequence	112025-112056	7	0.781
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NZ_LR027555	Epibacterium mobile isolate EPIB1 plasmid 3, complete sequence	90457-90488	7	0.781
NZ_CP027371_4	4.1\|2926534\|32\|NZ_CP027371\|CRISPRCasFinder	2926534-2926565	32	KR080197	Mycobacterium phage FlagStaff, complete genome	15476-15507	7	0.781
NZ_CP027371_4	4.9\|2926654\|34\|NZ_CP027371\|CRT	2926654-2926687	34	MT740736	Ralstonia phage Eline, complete genome	499-532	7	0.794
NZ_CP027371_4	4.9\|2926654\|34\|NZ_CP027371\|CRT	2926654-2926687	34	MT740739	Ralstonia phage Gerry, complete genome	48442-48475	7	0.794
NZ_CP027371_4	4.15\|2926655\|34\|NZ_CP027371\|PILER-CR	2926655-2926688	34	MT740736	Ralstonia phage Eline, complete genome	499-532	7	0.794
NZ_CP027371_4	4.15\|2926655\|34\|NZ_CP027371\|PILER-CR	2926655-2926688	34	MT740739	Ralstonia phage Gerry, complete genome	48442-48475	7	0.794
NZ_CP027371_1	1.2\|878106\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878106-878137	32	NC_021067	Vibrio phage helene 12B3 genomic sequence	11083-11114	8	0.75
NZ_CP027371_1	1.6\|878346\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878346-878377	32	NC_015583	Novosphingobium sp. PP1Y plasmid Mpl, complete sequence	1097936-1097967	8	0.75
NZ_CP027371_1	1.8\|878466\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878466-878497	32	NZ_AP023206	Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence	228610-228641	8	0.75
NZ_CP027371_1	1.12\|878706\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878706-878737	32	NZ_LR134457	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 15, complete sequence	34172-34203	8	0.75
NZ_CP027371_1	1.13\|878766\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878766-878797	32	NZ_LR134456	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence	209791-209822	8	0.75
NZ_CP027371_3	3.1\|2900258\|32\|NZ_CP027371\|CRT	2900258-2900289	32	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1428097-1428128	8	0.75
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NZ_CP013856	Pseudonocardia sp. HH130630-07 plasmid pLS2-2, complete sequence	81256-81287	8	0.75
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	MK064565	Sulfolobales Beppu rod-shaped virus 1 clone D, complete genome	8044-8075	8	0.75
NZ_CP027371_3	3.9\|2900746\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900746-2900777	32	NZ_KY515226	Salmonella enterica subsp. enterica serovar Derby strain S701 plasmid AnCo3, complete sequence	9271-9302	8	0.75
NZ_CP027371_4	4.1\|2926534\|32\|NZ_CP027371\|CRISPRCasFinder	2926534-2926565	32	NZ_CP014600	Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence	15418-15449	8	0.75
NZ_CP027371_1	1.2\|878106\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878106-878137	32	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	439300-439331	9	0.719
NZ_CP027371_1	1.11\|878646\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878646-878677	32	NZ_CP045307	Legionella longbeachae strain B41211CHC plasmid pB41211CHC_76k, complete sequence	65108-65139	9	0.719
NZ_CP027371_1	1.12\|878706\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878706-878737	32	NZ_CP016485	Synechococcus sp. PCC 8807 plasmid unnamed2, complete sequence	2910-2941	9	0.719
NZ_CP027371_3	3.1\|2900258\|32\|NZ_CP027371\|CRT	2900258-2900289	32	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	141278-141309	9	0.719
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NZ_CP010647	Phaeobacter piscinae strain P36 plasmid pP36_d, complete sequence	70883-70914	9	0.719
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NZ_LN907828	Erwinia gerundensis isolate E_g_EM595 plasmid pEM01, complete sequence	312646-312677	9	0.719
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_CP013682	Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence	145876-145907	9	0.719
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	NZ_CP013295	Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence	156592-156623	9	0.719
NZ_CP027371_3	3.7\|2900624\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900624-2900655	32	MN694366	Marine virus AFVG_250M1050, complete genome	2162-2193	9	0.719
NZ_CP027371_4	4.1\|2926534\|32\|NZ_CP027371\|CRISPRCasFinder	2926534-2926565	32	NZ_CP009292	Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence	139210-139241	9	0.719
NZ_CP027371_4	4.6\|2926839\|32\|NZ_CP027371\|CRISPRCasFinder	2926839-2926870	32	MK448935	Streptococcus phage Javan424, complete genome	17153-17184	9	0.719
NZ_CP027371_4	4.6\|2926839\|32\|NZ_CP027371\|CRISPRCasFinder	2926839-2926870	32	MK448936	Streptococcus phage Javan426, complete genome	17153-17184	9	0.719
NZ_CP027371_1	1.13\|878766\|32\|NZ_CP027371\|PILER-CR,CRISPRCasFinder,CRT	878766-878797	32	NZ_LR134451	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence	148490-148521	10	0.688
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	699305-699336	10	0.688
NZ_CP027371_3	3.5\|2900502\|32\|NZ_CP027371\|CRT,PILER-CR,CRISPRCasFinder	2900502-2900533	32	NC_015724	Cupriavidus necator N-1 plasmid pBB2, complete sequence	169020-169051	10	0.688
NZ_CP027371_4	4.1\|2926534\|32\|NZ_CP027371\|CRISPRCasFinder	2926534-2926565	32	NZ_CP012383	Streptomyces ambofaciens ATCC 23877 plasmid pSAM1, complete sequence	14130-14161	10	0.688
NZ_CP027371_4	4.4\|2926717\|32\|NZ_CP027371\|CRISPRCasFinder	2926717-2926748	32	NZ_CP022424	Vitreoscilla filiformis strain ATCC 15551 plasmid pVF1, complete sequence	187136-187167	10	0.688
NZ_CP027371_4	4.7\|2926532\|34\|NZ_CP027371\|CRT	2926532-2926565	34	NZ_CP014600	Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence	15418-15451	10	0.706
NZ_CP027371_4	4.13\|2926533\|34\|NZ_CP027371\|PILER-CR	2926533-2926566	34	NZ_CP014600	Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence	15418-15451	10	0.706
NZ_CP027371_2	2.1\|2198842\|58\|NZ_CP027371\|CRISPRCasFinder	2198842-2198899	58	NZ_CP044147	Escherichia coli O157 strain AR-0428 plasmid pAR-0428-2	7432-7489	11	0.81
NZ_CP027371_2	2.1\|2198842\|58\|NZ_CP027371\|CRISPRCasFinder	2198842-2198899	58	CP044351	Escherichia coli strain 194195 plasmid p194195_1, complete sequence	84256-84313	11	0.81
NZ_CP027371_4	4.7\|2926532\|34\|NZ_CP027371\|CRT	2926532-2926565	34	NZ_CP009292	Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence	139208-139241	11	0.676
NZ_CP027371_4	4.13\|2926533\|34\|NZ_CP027371\|PILER-CR	2926533-2926566	34	NZ_CP009292	Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence	139208-139241	11	0.676

1. spacer 3.1|2900258|32|NZ_CP027371|CRT matches to LC542972 (Escherichia coli IOMTU792 plasmid pIOMTU792 DNA, complete sequence) position: , mismatch: 3, identity: 0.906

taagtgatatccatcatcgcatccagtgcgcc	CRISPR spacer
caagtgatgtccatcatcgcatccagtgcgtc	Protospacer
.*******.*********************.*

2. spacer 4.6|2926839|32|NZ_CP027371|CRISPRCasFinder matches to LR134281 (Klebsiella aerogenes strain NCTC9793 genome assembly, plasmid: 6) position: , mismatch: 4, identity: 0.875

caagccgggatttgctttcggccagttggtct	CRISPR spacer
cagaccgggatttgctttcggccagtttgcct	Protospacer
**..*********************** *.**

3. spacer 2.1|2198842|58|NZ_CP027371|CRISPRCasFinder matches to MT230312 (Escherichia coli strain DH5alpha plasmid pESBL31, complete sequence) position: , mismatch: 5, identity: 0.914

agacccgagcacagaaccgtaggccggataaggcgttcacgccgcatccggcattcag	CRISPR spacer
agacccgagcacagaaccgtaggacggataaggcgttcacgccgcatccggcgatcgt	Protospacer
*********************** ****************************. **.

4. spacer 4.3|2926656|32|NZ_CP027371|CRISPRCasFinder matches to MT361768 (Ralstonia phage RPZH6, complete genome) position: , mismatch: 5, identity: 0.844

agagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
gtggaacgccgcactgatccacatcgcgtagg	Protospacer
. .****** ******************** *

5. spacer 4.3|2926656|32|NZ_CP027371|CRISPRCasFinder matches to MT361768 (Ralstonia phage RPZH6, complete genome) position: , mismatch: 5, identity: 0.844

agagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
gtggaacgccgcactgatccacatcgcgtagg	Protospacer
. .****** ******************** *

6. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP034578 (Lactococcus lactis subsp. lactis strain UC08 plasmid pUC08E, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

7. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP017930 (Lactobacillus sakei subsp. sakei DSM 20017 = JCM 1157 strain LT-13 plasmid pLs13-a, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

8. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP043525 (Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_01, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

9. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP014889 (Lactobacillus backii strain TMW 1.1991 plasmid pL11991-8, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

10. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NC_015860 (Lactococcus lactis subsp. lactis plasmid pIL1, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

11. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP022342 (Enterococcus faecium strain KUHS13 plasmid pKO1, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

12. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP044372 (Klebsiella pneumoniae strain 2018C01-046 plasmid p2018C01-046-4, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

13. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_MG674581 (Enterococcus faecium strain HL1 plasmid pHLSA, complete sequence) position: , mismatch: 6, identity: 0.812

-tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
attcatc-aaattttttccaatttattttttta	Protospacer
 *  *** **** *********.*********.

14. spacer 3.8|2900685|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP041426 (Escherichia coli strain STEC388 plasmid pSTEC388_1, complete sequence) position: , mismatch: 6, identity: 0.812

tttatcgtcgcatgaatcgcggtatccatatt	CRISPR spacer
ctggttgtcacatgaatcacggtatccatatt	Protospacer
.* .*.***.********.*************

15. spacer 4.3|2926656|32|NZ_CP027371|CRISPRCasFinder matches to MT740736 (Ralstonia phage Eline, complete genome) position: , mismatch: 6, identity: 0.812

agagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
gtggaatgcggcgctgatccacatcgcgtagg	Protospacer
. .***.*****.***************** *

16. spacer 4.3|2926656|32|NZ_CP027371|CRISPRCasFinder matches to MT740739 (Ralstonia phage Gerry, complete genome) position: , mismatch: 6, identity: 0.812

agagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
gtggaatgcggcgctgatccacatcgcgtagg	Protospacer
. .***.*****.***************** *

17. spacer 4.9|2926654|34|NZ_CP027371|CRT matches to MT361768 (Ralstonia phage RPZH6, complete genome) position: , mismatch: 6, identity: 0.824

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaacgccgcactgatccacatcgcgtagg	Protospacer
* . .****** ******************** *

18. spacer 4.9|2926654|34|NZ_CP027371|CRT matches to MT361768 (Ralstonia phage RPZH6, complete genome) position: , mismatch: 6, identity: 0.824

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaacgccgcactgatccacatcgcgtagg	Protospacer
* . .****** ******************** *

19. spacer 4.15|2926655|34|NZ_CP027371|PILER-CR matches to MT361768 (Ralstonia phage RPZH6, complete genome) position: , mismatch: 6, identity: 0.824

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaacgccgcactgatccacatcgcgtagg	Protospacer
* . .****** ******************** *

20. spacer 4.15|2926655|34|NZ_CP027371|PILER-CR matches to MT361768 (Ralstonia phage RPZH6, complete genome) position: , mismatch: 6, identity: 0.824

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaacgccgcactgatccacatcgcgtagg	Protospacer
* . .****** ******************** *

21. spacer 1.4|878226|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032893 (Enterobacter kobei strain WCHEK045523 plasmid p1_045523, complete sequence) position: , mismatch: 7, identity: 0.781

tgccagatatttcagatcatgaacggttgcgc	CRISPR spacer
agccagatatttcagatcataaatggtcgaag	Protospacer
 *******************.**.***.* .

22. spacer 3.1|2900258|32|NZ_CP027371|CRT matches to NZ_CP015038 (Burkholderia cenocepacia strain 895 plasmid pBcp895-1, complete sequence) position: , mismatch: 7, identity: 0.781

taagtgat-atccatcatcgcatccagtgcgcc	CRISPR spacer
-ggttgatcgtccttcatcgcagccagtgcgcc	Protospacer
 .. **** .*** ******** **********

23. spacer 3.2|2900319|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NC_030948 (Ralstonia phage RSP15 DNA, complete genome) position: , mismatch: 7, identity: 0.781

tgcaaaacaaaactgtattgatcgcgttttgt	CRISPR spacer
tgaagaacaaaactgtattgatcttctttcgg	Protospacer
** *.****************** . ***.*

24. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to CP022460 (Shigella sonnei strain 2015C-3807 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.781

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
catcgaccgcgccagcgccagtgcggcgcggt	Protospacer
...  ****.*********************.

25. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP015232 (Epibacterium mobile F1926 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.781

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
ccgagaccgtgccagcgcctttgcggcgcgcc	Protospacer
.  * **************  ********* *

26. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_LR027555 (Epibacterium mobile isolate EPIB1 plasmid 3, complete sequence) position: , mismatch: 7, identity: 0.781

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
ccgagaccgtgccagcgcctttgcggcgcgcc	Protospacer
.  * **************  ********* *

27. spacer 4.1|2926534|32|NZ_CP027371|CRISPRCasFinder matches to KR080197 (Mycobacterium phage FlagStaff, complete genome) position: , mismatch: 7, identity: 0.781

aacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
aacccggcgaacggcatcgcggcgccggcgtc	Protospacer
*** . * .****** ******** *******

28. spacer 4.9|2926654|34|NZ_CP027371|CRT matches to MT740736 (Ralstonia phage Eline, complete genome) position: , mismatch: 7, identity: 0.794

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaatgcggcgctgatccacatcgcgtagg	Protospacer
* . .***.*****.***************** *

29. spacer 4.9|2926654|34|NZ_CP027371|CRT matches to MT740739 (Ralstonia phage Gerry, complete genome) position: , mismatch: 7, identity: 0.794

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaatgcggcgctgatccacatcgcgtagg	Protospacer
* . .***.*****.***************** *

30. spacer 4.15|2926655|34|NZ_CP027371|PILER-CR matches to MT740736 (Ralstonia phage Eline, complete genome) position: , mismatch: 7, identity: 0.794

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaatgcggcgctgatccacatcgcgtagg	Protospacer
* . .***.*****.***************** *

31. spacer 4.15|2926655|34|NZ_CP027371|PILER-CR matches to MT740739 (Ralstonia phage Gerry, complete genome) position: , mismatch: 7, identity: 0.794

acagagaacgcggcactgatccacatcgcgtacg	CRISPR spacer
aggtggaatgcggcgctgatccacatcgcgtagg	Protospacer
* . .***.*****.***************** *

32. spacer 1.2|878106|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NC_021067 (Vibrio phage helene 12B3 genomic sequence) position: , mismatch: 8, identity: 0.75

cggcagaaaaaccggtcgcgctaatggagaaa	CRISPR spacer
caacccaaaaaccagtcgctctaatggagtac	Protospacer
*..*  *******.***** ********* *

33. spacer 1.6|878346|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NC_015583 (Novosphingobium sp. PP1Y plasmid Mpl, complete sequence) position: , mismatch: 8, identity: 0.75

gtcatcggtatcgtcacgcgcaagggattcaa--	CRISPR spacer
ctcatcggtgtcgtcacgagcaa--gatcgcacc	Protospacer
 ********.******** ****  ***.  *

34. spacer 1.8|878466|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP023206 (Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence) position: , mismatch: 8, identity: 0.75

aatcgtagggcacacccttacggcagttaaaa	CRISPR spacer
catgatagggcacaccattacggtagtttgga	Protospacer
 ** .*********** ******.**** ..*

35. spacer 1.12|878706|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134457 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 15, complete sequence) position: , mismatch: 8, identity: 0.75

tgaacgcgatccgggcgattcgggagttttcg	CRISPR spacer
cggcggcgatccgggcgattcggaggttcacg	Protospacer
.*.  ******************..***. **

36. spacer 1.13|878766|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134456 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence) position: , mismatch: 8, identity: 0.75

ttcaccgagtgggtgctcgtgctgaatgaact	CRISPR spacer
ctcaccgagtaggtgctggtgctgagagtgcc	Protospacer
.*********.****** *******. * .*.

37. spacer 3.1|2900258|32|NZ_CP027371|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 8, identity: 0.75

taagtg---atatccatcatcgcatccagtgcgcc	CRISPR spacer
---gtgcgcccctccatcaccgcttccagtgcgcc	Protospacer
   ***    . *******.*** ***********

38. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP013856 (Pseudonocardia sp. HH130630-07 plasmid pLS2-2, complete sequence) position: , mismatch: 8, identity: 0.75

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
cacgaacagtgtcagcgccagtgcggcgacgc	Protospacer
..*. ** ***.****************  **

39. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to MK064565 (Sulfolobales Beppu rod-shaped virus 1 clone D, complete genome) position: , mismatch: 8, identity: 0.75

---tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
aattaaa---aaatgttttccagtctcttttttgt	Protospacer
   *.**   ************.*** ******

40. spacer 3.9|2900746|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_KY515226 (Salmonella enterica subsp. enterica serovar Derby strain S701 plasmid AnCo3, complete sequence) position: , mismatch: 8, identity: 0.75

gtccatcattgccttgttgatatacacaacgc	CRISPR spacer
atcgcatactgccttgttggtatagacaacgc	Protospacer
.**   .*.**********.**** *******

41. spacer 4.1|2926534|32|NZ_CP027371|CRISPRCasFinder matches to NZ_CP014600 (Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.75

aacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
ggctgtggaaagggctgcgcggcggcggcgac	Protospacer
..*  .***** **** ************* *

42. spacer 1.2|878106|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 9, identity: 0.719

cggcagaaaaaccggtcgcgctaatggagaaa	CRISPR spacer
tgcgccaaaaaccgggcgcgcgaatggagatt	Protospacer
.*    ********* ***** ********

43. spacer 1.11|878646|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045307 (Legionella longbeachae strain B41211CHC plasmid pB41211CHC_76k, complete sequence) position: , mismatch: 9, identity: 0.719

tggcatgcaatcactacagctattaatttcta	CRISPR spacer
gtaaaagacatcaatacaactattaatttcta	Protospacer
  . * *  **** ****.*************

44. spacer 1.12|878706|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016485 (Synechococcus sp. PCC 8807 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.719

tgaacgcgatccgggcgattcgg-----gagttttcg	CRISPR spacer
tgatcgcgatccgggcgatccggccaatggat-----	Protospacer
*** ***************.***     *..*

45. spacer 3.1|2900258|32|NZ_CP027371|CRT matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 9, identity: 0.719

taagtgatatccatcatcgcatccagtgcgcc	CRISPR spacer
ctcatcgcatccatcatcggttccagtgcgcc	Protospacer
.  .* ..***********  ***********

46. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP010647 (Phaeobacter piscinae strain P36 plasmid pP36_d, complete sequence) position: , mismatch: 9, identity: 0.719

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
cttgcagcctgccagcgccagggcggcgcagc	Protospacer
. ...* * ************ *******.**

47. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_LN907828 (Erwinia gerundensis isolate E_g_EM595 plasmid pEM01, complete sequence) position: , mismatch: 9, identity: 0.719

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
tacgcctgctgccagcgccagtgctgcgccgc	Protospacer
*.*.. .  *************** **** **

48. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP013682 (Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence) position: , mismatch: 9, identity: 0.719

tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
gtcttctaaatgttttataatctattttatct	Protospacer
    ************ .********** *.

49. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP013295 (Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence) position: , mismatch: 9, identity: 0.719

tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
gtcttctaaatgttttataatctattttatct	Protospacer
    ************ .********** *.

50. spacer 3.7|2900624|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to MN694366 (Marine virus AFVG_250M1050, complete genome) position: , mismatch: 9, identity: 0.719

tgaatctaaatgttttccaatctatttttttg	CRISPR spacer
ttgccttttatgtgttcaaatctatttttttg	Protospacer
* . ..*  **** *** **************

51. spacer 4.1|2926534|32|NZ_CP027371|CRISPRCasFinder matches to NZ_CP009292 (Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence) position: , mismatch: 9, identity: 0.719

aacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
cccgggaaaaacgggttcgcggcggcggcttc	Protospacer
  *.  ..****** ************** **

52. spacer 4.6|2926839|32|NZ_CP027371|CRISPRCasFinder matches to MK448935 (Streptococcus phage Javan424, complete genome) position: , mismatch: 9, identity: 0.719

caagccgggatttgctttcggccagttggtct	CRISPR spacer
aagtgagggattagctttcagccagttggctt	Protospacer
 *.   ****** ******.*********..*

53. spacer 4.6|2926839|32|NZ_CP027371|CRISPRCasFinder matches to MK448936 (Streptococcus phage Javan426, complete genome) position: , mismatch: 9, identity: 0.719

caagccgggatttgctttcggccagttggtct	CRISPR spacer
aagtgagggattagctttcagccagttggctt	Protospacer
 *.   ****** ******.*********..*

54. spacer 1.13|878766|32|NZ_CP027371|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134451 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence) position: , mismatch: 10, identity: 0.688

ttcaccgagtgggtgctcgtgctgaatgaact	CRISPR spacer
ctcacggagtgggtgctcgggctgtcgggggc	Protospacer
.**** ************* ****   *.. .

55. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 10, identity: 0.688

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
ctcgctgcgtgccaccgccagttcggcgcgca	Protospacer
. *..  ******* ******* *******

56. spacer 3.5|2900502|32|NZ_CP027371|CRT,PILER-CR,CRISPRCasFinder matches to NC_015724 (Cupriavidus necator N-1 plasmid pBB2, complete sequence) position: , mismatch: 10, identity: 0.688

tgcataccgtgccagcgccagtgcggcgcggc	CRISPR spacer
ctcgctgcgtgccaccgccagttcggcgcgca	Protospacer
. *..  ******* ******* *******

57. spacer 4.1|2926534|32|NZ_CP027371|CRISPRCasFinder matches to NZ_CP012383 (Streptomyces ambofaciens ATCC 23877 plasmid pSAM1, complete sequence) position: , mismatch: 10, identity: 0.688

aacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
gaggacggaagcggcttcgccgcggcgggcaa	Protospacer
.* . *****.********* *******

58. spacer 4.4|2926717|32|NZ_CP027371|CRISPRCasFinder matches to NZ_CP022424 (Vitreoscilla filiformis strain ATCC 15551 plasmid pVF1, complete sequence) position: , mismatch: 10, identity: 0.688

tcagccaagttttgcgcccggcgcaagtagcg	CRISPR spacer
cccaccaagctttgcgccaggcgcaagcgcaa	Protospacer
.* .*****.******** ********..  .

59. spacer 4.7|2926532|34|NZ_CP027371|CRT matches to NZ_CP014600 (Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.706

tcaacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
ggggctgtggaaagggctgcgcggcggcggcgac	Protospacer
  ..*  .***** **** ************* *

60. spacer 4.13|2926533|34|NZ_CP027371|PILER-CR matches to NZ_CP014600 (Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.706

tcaacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
ggggctgtggaaagggctgcgcggcggcggcgac	Protospacer
  ..*  .***** **** ************* *

61. spacer 2.1|2198842|58|NZ_CP027371|CRISPRCasFinder matches to NZ_CP044147 (Escherichia coli O157 strain AR-0428 plasmid pAR-0428-2) position: , mismatch: 11, identity: 0.81

---agacccgagcacagaaccgtaggccggataaggcgttcacgccgcatccggcattca	CRISPR spacer
acaaaact---gcactcaaccgtaggccggataaggcgttcacgccgcatccggcaattg	Protospacer
   *.**.   ****  *************************************** *..

62. spacer 2.1|2198842|58|NZ_CP027371|CRISPRCasFinder matches to CP044351 (Escherichia coli strain 194195 plasmid p194195_1, complete sequence) position: , mismatch: 11, identity: 0.81

---agacccgagcacagaaccgtaggccggataaggcgttcacgccgcatccggcattca	CRISPR spacer
acaaaact---gcactcaaccgtaggccggataaggcgttcacgccgcatccggcaattg	Protospacer
   *.**.   ****  *************************************** *..

63. spacer 4.7|2926532|34|NZ_CP027371|CRT matches to NZ_CP009292 (Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence) position: , mismatch: 11, identity: 0.676

tcaacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
ggcccgggaaaaacgggttcgcggcggcggcttc	Protospacer
    *.  ..****** ************** **

64. spacer 4.13|2926533|34|NZ_CP027371|PILER-CR matches to NZ_CP009292 (Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence) position: , mismatch: 11, identity: 0.676

tcaacatcggaaacggcttcgcggcggcggcgtc	CRISPR spacer
ggcccgggaaaaacgggttcgcggcggcggcttc	Protospacer
    *.  ..****** ************** **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

438381 : 505247

Enterobacteria_phage(55.17%)

tail,protease,lysis,capsid,portal,tRNA,transposase,terminase,head,integrase

attL 448543:448589|attR 496721:496767

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000912345.1\|438381_439767_+\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	3.9e-45	34.8
WP_001143565.1\|439802_440324_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_000190288.1\|440431_440644_-	ribosome-associated protein YbcJ	NA	NA	NA	NA
WP_000729161.1\|440645_441512_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	1.7e-30	37.5
WP_000776555.1\|441992_442535_+	type 1 fimbrial protein subunit FimA	NA	NA	NA	NA
WP_106879065.1\|442754_443447_+	type 1 fimbria chaperone FimC	NA	NA	NA	NA
WP_001356128.1\|443477_446087_+	fimbrial biogenesis usher protein	NA	NA	NA	NA
WP_106879066.1\|446099_447107_+	type 1 fimbrin D-mannose specific adhesin FimH	NA	NA	NA	NA
WP_001250424.1\|447117_447633_+	fimbria assembly protein	NA	NA	NA	NA
WP_000805422.1\|447635_448268_-	fimbria biosynthesis transcriptional regulator FimZ	NA	NA	NA	NA
448543:448589	attL	NA	NA	NA	NA
WP_000051902.1\|448602_449766_-\|integrase	site-specific integrase	A0A088CD23	Shigella_phage	3.0e-200	86.6
WP_000446905.1\|449621_449993_-	helix-turn-helix domain-containing protein	M1FJ59	Enterobacteria_phage	2.1e-46	81.0
WP_000488407.1\|449964_450243_-	DUF4222 domain-containing protein	M1FPC8	Enterobacteria_phage	4.9e-48	97.8
WP_000763385.1\|450290_450509_-	TraR/DksA family transcriptional regulator	M1FQT7	Enterobacteria_phage	7.5e-36	100.0
WP_001443983.1\|450607_450889_-	hypothetical protein	A0A0P0ZE02	Stx2-converting_phage	7.2e-47	98.9
WP_000548537.1\|450899_451091_-	DUF1382 family protein	A0A0P0ZC67	Stx2-converting_phage	2.1e-26	98.4
WP_000149544.1\|451063_451246_-	DUF1317 domain-containing protein	A0A1U8QQC1	Enterobacteria_phage	6.9e-27	96.7
WP_000611716.1\|451242_451923_-	YqaJ viral recombinase family protein	B6DZ61	Enterobacteria_phage	3.0e-131	98.2
WP_000100847.1\|451919_452705_-	phage recombination protein Bet	A0A1I9LJN0	Stx_converting_phage	6.3e-149	100.0
WP_000995453.1\|452710_453007_-	host-nuclease inhibitor protein Gam	A0A1I9LJN1	Stx_converting_phage	1.8e-48	98.0
WP_023143023.1\|453082_453373_-	hypothetical protein	K7P6H3	Enterobacteria_phage	4.2e-26	83.6
WP_000858975.1\|453884_454574_-	helix-turn-helix transcriptional regulator	Q76H56	Enterobacteria_phage	2.8e-92	75.0
WP_001067458.1\|454678_454909_+	helix-turn-helix domain-containing protein	A0A2H4FNF3	Salmonella_phage	1.5e-21	68.0
WP_001182893.1\|454978_455518_+	hypothetical protein	K7PJT7	Enterobacteria_phage	2.2e-60	66.5
WP_001378761.1\|455604_456534_+	replication protein	A0A0K2FJ31	Enterobacteria_phage	1.0e-110	67.6
WP_000788786.1\|456530_457232_+	Replication protein P	K7P6G2	Enterobacteria_phage	1.3e-129	99.6
WP_000145915.1\|457228_457531_+	protein ren	A0A0N6WES4	Escherichia_phage	1.1e-42	95.7
WP_001070442.1\|457598_457931_+	SMR family multidrug efflux protein EmrE	NA	NA	NA	NA
WP_032139864.1\|458022_458130_+	hypothetical protein	NA	NA	NA	NA
WP_000709069.1\|458187_459714_+	recombinase family protein	Q3HQV4	Burkholderia_phage	6.1e-31	27.7
WP_001365992.1\|459936_460074_-	hypothetical protein	NA	NA	NA	NA
WP_000068668.1\|460347_461277_+	hypothetical protein	A0A1R3Y6Z6	Salmonella_virus	3.0e-57	40.0
WP_001309322.1\|461375_461477_+	hypothetical protein	NA	NA	NA	NA
WP_001053033.1\|461473_461929_+	DNA base-flipping protein YbcN	I6PD71	Cronobacter_phage	3.7e-61	67.5
WP_000224919.1\|461928_462099_+	NinE family protein	NA	NA	NA	NA
WP_000774488.1\|462091_462382_+	DUF1364 domain-containing protein	K7PGZ6	Enterobacteria_phage	4.3e-47	94.8
WP_001099700.1\|462378_462741_+	crossover junction endodeoxyribonuclease RusA	K7PM48	Enterobacteria_phage	7.3e-60	96.5
WP_000971068.1\|462737_462878_+	YlcG family protein	K7PHH3	Enterobacteria_phage	5.5e-08	67.4
WP_001204791.1\|462963_463347_+	antitermination protein QuuD	A0A088CD47	Shigella_phage	4.4e-55	83.3
WP_000737266.1\|463536_464634_-	porin	Q1MVN1	Enterobacteria_phage	2.2e-155	76.5
WP_000839596.1\|465222_465438_+\|lysis	phage lysis protein EssD	A5LH82	Enterobacteria_phage	9.0e-34	100.0
WP_001135277.1\|465437_465935_+	lysozyme	M1FJA0	Enterobacteria_phage	5.4e-90	97.0
WP_001228695.1\|466151_466334_+\|lysis	prophage lysis lipoprotein RzoD	K7PHU6	Enterobacteria_phage	2.9e-17	98.3
WP_000738423.1\|466424_466718_-	increased serum survival lipoprotein Iss	K7PL54	Enterobacteria_phage	2.0e-44	91.8
WP_001415975.1\|467077_467272_-	YlcI/YnfO family protein	A0A0K2FIR8	Escherichia_phage	4.3e-27	96.9
WP_063082806.1\|467660_468206_+	DNA-packaging protein	A0A0K2FIG2	Enterobacteria_phage	4.0e-94	98.3
WP_001027283.1\|468180_470106_+\|terminase	phage terminase large subunit family protein	A0A0K2FJ14	Enterobacteria_phage	0.0e+00	99.5
WP_000198149.1\|470102_470309_+\|head,tail	Lambda prophage-derived head-to-tail joining protein W	A0A2R9YJL2	Escherichia_phage	5.8e-30	100.0
WP_001369921.1\|470305_471907_+\|portal	phage portal protein	A0A0K2FJC0	Enterobacteria_phage	1.9e-309	98.9
WP_000123309.1\|471887_473207_+	S49 family peptidase	A0A0K2FI53	Enterobacteria_phage	7.4e-235	99.1
WP_001378764.1\|473216_473549_+\|head	head decoration protein	A0A2R9YJN3	Escherichia_phage	4.2e-54	97.3
WP_000063221.1\|473604_474630_+\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	8.1e-189	97.9
WP_000158880.1\|474671_475067_+	DNA-packaging protein FI	A0A2R9YJP4	Escherichia_phage	2.2e-57	93.9
WP_000752981.1\|475078_475432_+\|tail	tail attachment protein	A0A2R9YJJ5	Escherichia_phage	9.9e-62	99.1
WP_000975110.1\|475443_476022_+\|tail	phage tail protein	A0A2R9YJK4	Escherichia_phage	5.0e-79	97.4
WP_000683142.1\|476018_476414_+\|tail	tail protein	A0A2R9YJI2	Escherichia_phage	2.9e-70	99.2
WP_001378767.1\|476421_477162_+\|tail	phage tail protein	A0A0K2FJ05	Enterobacteria_phage	6.8e-129	97.2
WP_000479193.1\|477177_477600_+\|tail	phage minor tail protein G	A0A0K2FIQ8	Enterobacteria_phage	2.2e-60	85.7
WP_000459457.1\|477581_478016_+\|tail	phage tail assembly protein T	A0A0K2FJB3	Enterobacteria_phage	6.9e-65	100.0
WP_001774776.1\|478008_480588_+\|tail	phage tail tape measure protein	A0A2R9YJM8	Escherichia_phage	0.0e+00	90.5
WP_000847379.1\|480584_480914_+\|tail	phage tail protein	A0A0K2FIE9	Enterobacteria_phage	9.6e-59	100.0
WP_001152639.1\|480913_481612_+\|tail	phage minor tail protein L	A0A0K2FJ01	Enterobacteria_phage	2.3e-134	100.0
WP_000194783.1\|481617_482361_+\|tail	phage tail protein	K7PLW1	Enterobacteria_phage	1.2e-146	96.4
WP_000090895.1\|482297_482930_+\|tail	tail assembly protein	A0A2R9YJH6	Escherichia_phage	5.5e-95	89.5
WP_061091987.1\|482990_486404_+	host specificity protein J	K7PKJ2	Enterobacteria_phage	0.0e+00	97.6
WP_001233071.1\|486474_487074_+	Ail/Lom family outer membrane beta-barrel protein	A0A291AWV3	Escherichia_phage	4.4e-110	98.5
WP_000279163.1\|487138_490099_+	hypothetical protein	A0A0K2FIZ6	Escherichia_phage	4.0e-55	53.7
WP_000885616.1\|490098_490674_+\|tail	tail fiber assembly protein	K7PMH7	Enterobacteria_phage	6.5e-103	95.3
WP_000086514.1\|490771_491362_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	7.3e-25	38.8
WP_000836768.1\|491678_491912_-	cold shock protein YdfK	A0A192Y6D5	Salmonella_phage	1.1e-32	88.3
WP_120795384.1\|491980_492094_-	Rac prophage; protein YnaM	A0A1C9IHU6	Salmonella_phage	8.4e-07	80.6
WP_000239874.1\|492459_493128_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_001226378.1\|493673_495158_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001201825.1\|495344_496298_-\|protease	omptin family outer membrane protease OmpT	NA	NA	NA	NA
WP_001177464.1\|496810_497572_-	DNA-binding transcriptional regulator EnvY	NA	NA	NA	NA
496721:496767	attR	NA	NA	NA	NA
WP_001224567.1\|497754_498645_-	DUF4434 family protein	NA	NA	NA	NA
WP_000662366.1\|498645_501618_-	bacteriophage adsorption protein NfrA	NA	NA	NA	NA
WP_000383945.1\|501604_503842_-	phage adsorption protein NrfB	NA	NA	NA	NA
WP_000394594.1\|504110_505247_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

772789 : 883271

108

Salmonella_phage(60.38%)

tail,protease,lysis,capsid,portal,transposase,terminase,head,plate,integrase

attL 798515:798530|attR 813591:813606

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000399648.1\|772789_773770_+\|transposase	IS110-like element IS621 family transposase	NA	NA	NA	NA
WP_000168797.1\|774025_775291_-	DUF1479 domain-containing protein	NA	NA	NA	NA
WP_000114234.1\|775442_776258_-	sugar-phosphatase YbiV	NA	NA	NA	NA
WP_000209359.1\|776403_778836_-	glycyl radical protein	A0A076YHZ7	Citrobacter_phage	6.1e-09	43.5
WP_001295295.1\|778841_779741_-	glycyl-radical enzyme activating protein	NA	NA	NA	NA
WP_000424890.1\|779871_780534_+	fructose-6-phosphate aldolase	A0A0E3HJ81	Synechococcus_phage	5.7e-26	34.6
WP_000829258.1\|780609_781359_-	molybdopterin-synthase adenylyltransferase MoeB	NA	NA	NA	NA
WP_000397404.1\|781358_782594_-	molybdopterin molybdotransferase MoeA	NA	NA	NA	NA
WP_000513775.1\|782797_783763_+	beta-aspartyl-peptidase	NA	NA	NA	NA
WP_001296993.1\|783749_785621_+	glutathione ABC transporter ATP-binding protein GsiA	G9BWD6	Planktothrix_phage	4.0e-16	29.7
WP_000090130.1\|785640_787179_+	glutathione ABC transporter substrate-binding protein GsiB	NA	NA	NA	NA
WP_000936043.1\|787196_788117_+	glutathione ABC transporter permease GsiC	NA	NA	NA	NA
WP_001236044.1\|788119_789031_+	glutathione ABC transporter permease GsiD	NA	NA	NA	NA
WP_001307078.1\|789208_791557_+	EAL domain-containing protein	NA	NA	NA	NA
WP_000086910.1\|791564_792893_+	GGDEF domain-containing protein	NA	NA	NA	NA
WP_000049367.1\|792939_794265_-	30S ribosomal protein S12 methylthiotransferase RimO	NA	NA	NA	NA
WP_000497137.1\|794477_794861_+	biofilm formation regulator BssR	NA	NA	NA	NA
WP_000555035.1\|794971_796087_+	PQQ-dependent sugar dehydrogenase	NA	NA	NA	NA
WP_001295292.1\|796083_796710_-	glutathione S-transferase family protein	NA	NA	NA	NA
WP_000195961.1\|796956_798159_+	serine-type D-Ala-D-Ala carboxypeptidase	B6DZZ7	Stx2-converting_phage	8.2e-100	48.0
WP_000450133.1\|798205_798964_-	DNA-binding transcriptional repressor DeoR	NA	NA	NA	NA
798515:798530	attL	NA	NA	NA	NA
WP_000892317.1\|799021_799618_-	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_001180098.1\|799902_801135_+	multidrug efflux MFS transporter MdfA	NA	NA	NA	NA
WP_000480892.1\|801175_801460_-	hypothetical protein	NA	NA	NA	NA
WP_001297001.1\|801545_802361_-	5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase	NA	NA	NA	NA
WP_000217848.1\|802360_803569_-	MFS transporter	NA	NA	NA	NA
WP_001297003.1\|803652_804189_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_001032044.1\|804339_804609_-	hypothetical protein	NA	NA	NA	NA
WP_000290938.1\|804667_805699_-\|integrase	tyrosine-type recombinase/integrase	A0A218M4I3	Erwinia_phage	1.9e-105	56.1
WP_023150405.1\|805782_807459_-	DUF4041 domain-containing protein	A0A142LP25	Marinitoga_camini_virus	5.7e-83	67.0
WP_106879071.1\|807479_808076_-	phage repressor protein CI	A0A1S6KZZ7	Salmonella_phage	1.1e-39	42.4
WP_000188448.1\|808171_808393_+	hypothetical protein	NA	NA	NA	NA
WP_000460901.1\|808425_808935_+	phage regulatory CII family protein	E5G6L3	Salmonella_phage	1.7e-86	98.2
WP_023150404.1\|808942_809143_+	DUF2724 domain-containing protein	E5G6L4	Salmonella_phage	3.5e-32	97.0
WP_000963472.1\|809106_809448_+	DUF5347 domain-containing protein	E5G6L5	Salmonella_phage	1.3e-55	98.2
WP_001244165.1\|809515_809749_+	DUF2732 family protein	E5G6L6	Salmonella_phage	1.9e-32	97.4
WP_000752613.1\|809748_809976_+	TraR/DksA family transcriptional regulator	E5G6L7	Salmonella_phage	2.7e-36	100.0
WP_106879072.1\|809972_810830_+	DNA adenine methylase	E5G6L8	Salmonella_phage	3.9e-160	96.5
WP_106879073.1\|810826_813241_+	replication endonuclease	E5G6L9	Salmonella_phage	0.0e+00	98.4
WP_001154428.1\|813394_813583_+	hypothetical protein	E5G6M0	Salmonella_phage	5.1e-25	93.4
WP_106879074.1\|813753_814914_+	hypothetical protein	NA	NA	NA	NA
813591:813606	attR	NA	NA	NA	NA
WP_052928646.1\|815280_816348_+	hypothetical protein	NA	NA	NA	NA
WP_086258518.1\|816350_816665_+	STAS-like domain-containing protein	NA	NA	NA	NA
WP_130723475.1\|816670_817159_+	hypothetical protein	NA	NA	NA	NA
WP_104807779.1\|817243_818269_-\|portal	phage portal protein	E5G6M3	Salmonella_phage	1.4e-172	89.2
WP_089640747.1\|818268_820035_-\|terminase	terminase ATPase subunit family protein	A0A1S6KZW3	Salmonella_phage	0.0e+00	99.5
WP_106879075.1\|820177_821011_+\|capsid	GPO family capsid scaffolding protein	A0A1S6KZW9	Salmonella_phage	7.7e-121	89.5
WP_106879076.1\|821027_822086_+\|capsid	phage major capsid protein, P2 family	E5G6M6	Salmonella_phage	1.9e-180	92.8
WP_106879077.1\|822089_822740_+\|terminase	terminase endonuclease subunit	E5G6M7	Salmonella_phage	3.3e-111	95.4
WP_106879078.1\|822835_823300_+\|head	head completion/stabilization protein	A0A1S6KZW8	Salmonella_phage	3.2e-76	89.0
WP_000868192.1\|823299_823503_+\|tail	tail protein X	E5G6M9	Salmonella_phage	6.8e-31	91.0
WP_000171568.1\|823506_823722_+	hypothetical protein	E5G6N0	Salmonella_phage	1.8e-26	80.3
WP_001573376.1\|823702_824218_+	lysozyme	E5G6N1	Salmonella_phage	1.6e-89	92.4
WP_096970344.1\|824214_824643_+\|lysis	LysB family phage lysis regulatory protein	E5G6N2	Salmonella_phage	3.6e-58	90.1
WP_001039945.1\|824738_825170_+\|tail	phage tail protein	E5G6N3	Salmonella_phage	4.4e-72	94.4
WP_106879079.1\|825162_825609_+	phage virion morphogenesis protein	A0A1S6L001	Salmonella_phage	3.0e-63	85.6
WP_039516405.1\|825677_826256_+\|plate	phage baseplate assembly protein V	A0A1S6KZX7	Salmonella_phage	3.6e-93	85.9
WP_106879080.1\|826252_826612_+\|plate	baseplate assembly protein	A0A1S6KZZ4	Salmonella_phage	1.6e-51	86.6
WP_000268301.1\|826598_827507_+\|plate	baseplate assembly protein	A0A1S6KZY6	Salmonella_phage	4.1e-144	91.1
WP_001086820.1\|827499_828105_+\|tail	phage tail protein I	A0A1S6L000	Salmonella_phage	5.2e-111	92.5
WP_000905033.1\|831054_831621_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	3.8e-87	86.8
WP_001726272.1\|831762_832935_+\|tail	phage tail sheath protein	A0A1S6KZY7	Salmonella_phage	1.6e-204	90.5
WP_001504081.1\|832944_833460_+\|tail	phage major tail tube protein	A0A1S6L002	Salmonella_phage	4.8e-89	94.7
WP_001281013.1\|833514_833817_+\|tail	phage tail assembly protein	A0A1S6KZZ9	Salmonella_phage	7.0e-40	89.0
WP_000763311.1\|833831_833951_+\|tail	GpE family phage tail protein	E5G6Q0	Salmonella_phage	2.8e-13	87.2
WP_046201501.1\|833943_837021_+\|tail	phage tail tape measure protein	E5G6Q1	Salmonella_phage	0.0e+00	63.4
WP_000980396.1\|837017_837503_+\|tail	phage tail protein	E5G6Q2	Salmonella_phage	2.2e-67	81.2
WP_046201500.1\|837499_838600_+	phage late control D family protein	E5G6Q3	Salmonella_phage	1.7e-176	85.5
WP_106879081.1\|838690_838936_+	transcriptional regulator	Q53ZE7	Salmonella_virus	6.5e-20	69.0
WP_001024876.1\|839142_840828_-	aspartate:alanine antiporter	NA	NA	NA	NA
WP_000681108.1\|841097_841475_+	hypothetical protein	NA	NA	NA	NA
WP_001195240.1\|841504_841762_-	glutaredoxin 1	A0A2I7SAE2	Vibrio_phage	8.6e-23	61.9
WP_001201560.1\|841921_842209_+	DUF1418 family protein	NA	NA	NA	NA
WP_106879082.1\|842192_842915_+	nitroreductase NfsA	NA	NA	NA	NA
WP_000684321.1\|842975_843878_+	30S ribosomal protein S6--L-glutamate ligase	I3ULC9	Synechococcus_phage	2.6e-37	34.4
WP_000203025.1\|843965_844442_+	YbjN domain-containing protein	NA	NA	NA	NA
WP_000126055.1\|844792_845905_+	spermidine/putrescine ABC transporter substrate-binding protein PotF	NA	NA	NA	NA
WP_000996018.1\|845999_847133_+	putrescine ABC transporter ATP-binding subunit PotG	G3M9Y6	Bacillus_virus	1.4e-29	34.0
WP_001093862.1\|847142_848096_+	putrescine ABC transporter permease PotH	NA	NA	NA	NA
WP_001061657.1\|848092_848938_+	putrescine ABC transporter permease PotI	NA	NA	NA	NA
WP_000389260.1\|848997_849486_+	YbjO family protein	NA	NA	NA	NA
WP_001149739.1\|849526_850654_+	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	A0A1X9I6F4	Streptococcus_phage	6.0e-28	27.3
WP_001295905.1\|850828_851560_-	arginine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000399648.1\|852010_852991_+\|transposase	IS110-like element IS621 family transposase	NA	NA	NA	NA
WP_000464491.1\|853130_853799_-	arginine ABC transporter permease ArtM	NA	NA	NA	NA
WP_001001691.1\|853798_854515_-	arginine ABC transporter permease ArtQ	NA	NA	NA	NA
WP_000756569.1\|854521_855253_-	arginine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000027205.1\|855270_855999_-	arginine ABC transporter ATP-binding protein ArtP	G9BWD6	Planktothrix_phage	6.0e-29	36.7
WP_001270735.1\|856216_856732_-	lipoprotein	NA	NA	NA	NA
WP_001160737.1\|856857_857181_+	heavy metal-binding domain-containing protein	NA	NA	NA	NA
WP_001255144.1\|857177_858008_+	N-acetylmuramoyl-L-alanine amidase	A0A1B0UZW5	Roseobacter_phage	5.7e-07	30.0
WP_001338420.1\|858004_859018_-	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_001136554.1\|859116_860547_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_000566372.1\|860557_861559_-	low-specificity L-threonine aldolase	NA	NA	NA	NA
WP_106879083.1\|861595_863314_-	ubiquinone-dependent pyruvate dehydrogenase	A0A0P0YLY7	Yellowstone_lake_phycodnavirus	6.8e-31	24.1
WP_000178677.1\|863446_864415_-	NADH oxidoreductase	NA	NA	NA	NA
WP_000458817.1\|864426_866079_-	hydroxylamine reductase	NA	NA	NA	NA
WP_000491142.1\|866222_867122_-	L-lysine exporter LysO	NA	NA	NA	NA
WP_001356126.1\|867616_868312_-	aquaporin Z	NA	NA	NA	NA
WP_000599806.1\|868737_870396_+	ATP-dependent endonuclease	NA	NA	NA	NA
WP_001355621.1\|870392_871349_-	DUF535 domain-containing protein	NA	NA	NA	NA
WP_000746460.1\|871499_872615_+	macrolide transporter subunit MacA	NA	NA	NA	NA
WP_000188180.1\|872611_874558_+	macrolide ABC transporter ATP-binding protein/permease MacB	G9BWD6	Planktothrix_phage	1.1e-37	40.1
WP_000410785.1\|874630_874855_-	cold shock-like protein CspD	A0A2H4N7Y6	Lake_Baikal_phage	2.3e-16	61.2
WP_000241204.1\|875177_875498_+\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	1.6e-13	44.4
WP_000934053.1\|875528_877805_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	1.9e-166	42.5
WP_000097888.1\|879057_880041_+	type I-F CRISPR-associated endonuclease Cas1	A0A2D0YFC9	Vibrio_phage	2.9e-42	35.2
WP_001101569.1\|880037_883271_+	type I-F CRISPR-associated helicase Cas3	A0A2I7RCU8	Vibrio_phage	2.8e-62	28.8

DBSCAN-SWA_3

981254 : 1050246

Escherichia_phage(42.59%)

tail,holin,head,capsid,terminase,protease,integrase

attL 996350:996409|attR 1045512:1045573

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_106879087.1\|981254_983015_-\|protease	Lon protease family protein	NA	NA	NA	NA
WP_000877158.1\|983200_983653_+	macrodomain Ter protein MatP	NA	NA	NA	NA
WP_000750419.1\|983727_984780_-	porin OmpA	NA	NA	NA	NA
WP_000288710.1\|985136_985646_-	cell division inhibitor SulA	NA	NA	NA	NA
WP_106879088.1\|985864_986494_+	CRP-S regulon transcriptional coactivator Sxy	NA	NA	NA	NA
WP_000875044.1\|986456_988619_-	TIGR01666 family membrane protein	NA	NA	NA	NA
WP_001261231.1\|988628_989075_-	YccF domain-containing protein	NA	NA	NA	NA
WP_000420533.1\|989197_991252_+	DNA helicase IV	A7KV33	Bacillus_phage	7.7e-21	27.9
WP_000424181.1\|991283_991742_-	methylglyoxal synthase	NA	NA	NA	NA
WP_000847791.1\|991837_992500_-	DUF2057 family protein	NA	NA	NA	NA
WP_000665217.1\|992672_993086_+	CoA-binding protein	NA	NA	NA	NA
WP_001295356.1\|993130_993448_-	heat shock protein HspQ	NA	NA	NA	NA
WP_000116288.1\|993505_994696_-	23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI	NA	NA	NA	NA
WP_000048243.1\|994790_995069_+	acylphosphatase	NA	NA	NA	NA
WP_000904442.1\|995065_995395_-	sulfurtransferase TusE	NA	NA	NA	NA
WP_000375136.1\|995485_996145_-\|protease	FtsH protease modulator YccA	A0A2H4JFM9	uncultured_Caudovirales_phage	4.0e-48	55.3
996350:996409	attL	NA	NA	NA	NA
WP_001367167.1\|996552_997572_-\|integrase	tyrosine-type recombinase/integrase	A0A192Y7M7	Salmonella_phage	2.6e-86	50.3
WP_000273163.1\|997540_997792_-	DUF4224 domain-containing protein	NA	NA	NA	NA
WP_000092782.1\|1000340_1000529_-	DUF1482 family protein	NA	NA	NA	NA
WP_000450222.1\|1000525_1000714_-	cell division inhibitor	NA	NA	NA	NA
WP_106879207.1\|1001568_1001784_-	hypothetical protein	I6PDF6	Cronobacter_phage	4.1e-10	84.2
WP_000380319.1\|1001939_1002092_-	DUF1391 family protein	M4QQ57	Salicola_phage	6.6e-07	53.2
WP_000948456.1\|1002403_1002880_-	hypothetical protein	A0A2D1GNH0	Pseudomonas_phage	5.7e-12	53.4
WP_000712070.1\|1003004_1003328_+	transcriptional regulator	A0A0R6PH31	Moraxella_phage	1.4e-09	43.5
WP_000693925.1\|1003311_1003737_+	Rha family transcriptional regulator	NA	NA	NA	NA
WP_159029519.1\|1003805_1004837_+	phage replisome organizer	A0A0U2RT81	Escherichia_phage	9.9e-86	69.5
WP_072130322.1\|1004748_1005291_+	replication protein	A0A0U2JGJ0	Escherichia_phage	3.6e-79	90.2
WP_106879089.1\|1005324_1006041_+	DUF1627 domain-containing protein	A0A0U2SAW4	Escherichia_phage	1.1e-72	63.0
WP_074398695.1\|1006073_1006355_+	DNA-binding protein	A0A222YXX1	Escherichia_phage	7.2e-31	74.2
WP_064506980.1\|1006351_1006657_+	DUF4406 domain-containing protein	A0A0U2SAZ1	Escherichia_phage	4.4e-50	94.1
WP_044527398.1\|1006643_1007246_+	ead/Ea22-like family protein	A0A2R2Z315	Escherichia_phage	5.3e-39	49.5
WP_044527399.1\|1007343_1007769_+	hypothetical protein	A0A0A7NRY2	Enterobacteria_phage	1.2e-16	85.1
WP_000206823.1\|1008282_1008627_+	hypothetical protein	A0A2R2Z2X8	Escherichia_phage	3.3e-54	93.0
WP_000967410.1\|1008860_1009073_+	type I toxin-antitoxin system Hok family toxin	A0A0P0ZAX5	Stx2-converting_phage	2.8e-27	97.1
WP_044527401.1\|1009241_1009514_+	hypothetical protein	I6PCV7	Cronobacter_phage	2.1e-11	50.8
WP_064506981.1\|1009515_1010565_+	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	3.6e-115	58.2
WP_001204806.1\|1010582_1010963_+	antitermination protein Q	S5M7R9	Escherichia_phage	4.9e-67	100.0
WP_000917735.1\|1011178_1011376_+	hypothetical protein	S5MQK8	Escherichia_phage	1.8e-28	98.5
WP_000483497.1\|1011526_1012585_+	site-specific DNA-methyltransferase	S5MDR0	Escherichia_phage	2.3e-207	99.1
WP_032360617.1\|1012967_1013927_+	Shiga toxin Stx2 subunit A	Q776Q3	Enterobacteria_phage	2.1e-175	99.7
WP_000738072.1\|1013938_1014208_+	Shiga toxin Stx2a subunit B	Q6DWN4	Enterobacteria_phage	1.2e-43	100.0
WP_047090759.1\|1014505_1014829_-	anti-adapter protein IraM	Q20GJ2	Phage_258-320	6.5e-60	98.1
WP_106879090.1\|1015072_1017010_+	SASA family carbohydrate esterase	S5MDQ7	Escherichia_phage	0.0e+00	94.2
WP_000143458.1\|1017148_1017328_+	DUF1378 family protein	A0A2R2Z345	Escherichia_phage	2.2e-25	100.0
WP_001290230.1\|1017368_1017614_+	DUF826 domain-containing protein	A0A0P0ZGR2	Escherichia_phage	8.8e-17	100.0
WP_000284490.1\|1017691_1017907_+\|holin	holin	Q9ZWW2	Enterobacteria_phage	2.0e-33	98.6
WP_039264424.1\|1017910_1018702_+	DUF1327 domain-containing protein	Q08JA0	Stx2-converting_phage	4.0e-34	86.7
WP_001092874.1\|1019213_1019747_+	lysozyme	Q6H9V6	Enterobacteria_phage	1.4e-99	95.5
WP_051694738.1\|1019903_1020086_+	hypothetical protein	NA	NA	NA	NA
WP_135301858.1\|1020454_1020640_+	hypothetical protein	A0A0P0ZCT3	Stx2-converting_phage	1.1e-16	95.1
WP_000828070.1\|1021040_1021367_+	TonB family protein	H6WZK5	Escherichia_phage	6.3e-55	98.1
WP_000095744.1\|1021498_1021699_-	YlcI/YnfO family protein	H6WZK6	Escherichia_phage	1.3e-29	97.0
WP_000829192.1\|1021740_1022106_+	HNH endonuclease	B6ETE5	Enterobacteria_phage	1.6e-62	96.7
WP_000958387.1\|1022395_1022959_+\|terminase	terminase small subunit	A0A0N7KZJ8	Stx2-converting_phage	8.1e-90	100.0
WP_106879091.1\|1022955_1024617_+\|terminase	terminase large subunit	Q6H9U9	Enterobacteria_phage	0.0e+00	99.5
WP_096633151.1\|1024680_1026618_+\|capsid	phage major capsid protein	Q6H9U8	Enterobacteria_phage	0.0e+00	99.5
WP_001063099.1\|1026662_1026884_+	hypothetical protein	B6DZA0	Enterobacteria_phage	5.8e-36	100.0
WP_000125990.1\|1029248_1029575_+\|head,tail	phage gp6-like head-tail connector protein	A0A0P0ZBH1	Stx2-converting_phage	9.2e-54	100.0
WP_001007902.1\|1029584_1029935_+\|head	phage head closure protein	A0A0P0ZCU6	Stx2-converting_phage	2.0e-59	99.1
WP_106879092.1\|1029931_1030378_+	HK97 gp10 family phage protein	A0A0N7KZI9	Stx2-converting_phage	4.9e-74	98.0
WP_000133383.1\|1030374_1030719_+	DUF3168 domain-containing protein	A0A0P0ZC17	Stx2-converting_phage	4.2e-57	99.1
WP_039264404.1\|1030785_1031502_+\|tail	tail protein	A0A0P0ZDV1	Stx2-converting_phage	8.9e-126	98.7
WP_000710934.1\|1031516_1031891_+\|tail	tail assembly protein	A0A0P0ZE84	Stx2-converting_phage	7.8e-65	99.2
WP_122993267.1\|1031986_1032196_+	DUF4035 domain-containing protein	H6WZM0	Escherichia_phage	1.5e-33	98.6
WP_106879093.1\|1032243_1035486_+\|tail	phage tail tape measure protein	A0A0P0ZCJ4	Stx2-converting_phage	0.0e+00	87.8
WP_000343411.1\|1035478_1035820_+\|tail	phage tail protein	A0A0P0ZDL9	Stx2-converting_phage	6.9e-52	82.3
WP_001499019.1\|1035819_1036518_+\|tail	phage minor tail protein L	S5M7Q4	Escherichia_phage	2.1e-132	98.7
WP_039264406.1\|1036528_1037272_+\|tail	phage tail protein	S5MQI8	Escherichia_phage	3.8e-148	97.6
WP_122993618.1\|1037217_1037850_+\|tail	tail assembly protein	Q9EYE5	Enterobacteria_phage	1.9e-100	91.0
WP_106879094.1\|1038089_1041776_+	DUF1983 domain-containing protein	S5MW25	Escherichia_phage	0.0e+00	88.4
WP_000078853.1\|1041974_1042115_+	Hok/Gef family protein	S5M7Q0	Escherichia_phage	2.9e-17	95.7
WP_039264410.1\|1042259_1043972_+\|tail	phage tail protein	S5MDN9	Escherichia_phage	1.2e-67	51.0
WP_000438829.1\|1043981_1044194_+	hypothetical protein	NA	NA	NA	NA
WP_064506743.1\|1044205_1044880_+	DUF4376 domain-containing protein	S5MBX6	Escherichia_phage	9.6e-114	90.1
WP_022581964.1\|1045043_1045373_-	YkgJ family cysteine cluster protein	NA	NA	NA	NA
WP_001295940.1\|1046027_1047146_+	hydrogenase 1 small subunit	NA	NA	NA	NA
1045512:1045573	attR	NA	NA	NA	NA
WP_000107384.1\|1047142_1048936_+	Ni/Fe-hydrogenase large subunit	NA	NA	NA	NA
WP_001186424.1\|1048954_1049662_+	Ni/Fe-hydrogenase b-type cytochrome subunit	NA	NA	NA	NA
WP_000003663.1\|1049658_1050246_+\|protease	hydrogenase 1 maturation protease	NA	NA	NA	NA

DBSCAN-SWA_4

1194285 : 1276473

103

Escherichia_phage(40.3%)

tail,holin,lysis,capsid,portal,transposase,tRNA,terminase,head,integrase

attL 1236444:1236461|attR 1275567:1275584

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000952736.1\|1194285_1195107_+	NAD-dependent protein deacylase	A0A2I7S9Y2	Vibrio_phage	5.6e-23	35.6
WP_001620651.1\|1195245_1195773_-	hypothetical protein	NA	NA	NA	NA
WP_000422741.1\|1195916_1196342_+	IS66 family insertion sequence hypothetical protein	Q6H9S5	Enterobacteria_phage	1.5e-48	99.0
WP_000624722.1\|1196338_1196689_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	4.7e-40	66.4
WP_000080195.1\|1196719_1198333_+\|transposase	IS66-like element ISEc23 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.0e-182	63.6
WP_001373091.1\|1198443_1198908_+	IS66 family insertion sequence hypothetical protein	Q6H9S5	Enterobacteria_phage	3.2e-44	89.7
WP_000950104.1\|1198859_1199210_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	3.1e-39	65.5
WP_000080210.1\|1199240_1200833_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.9e-174	61.8
WP_106879104.1\|1200819_1201074_-	hypothetical protein	NA	NA	NA	NA
WP_001341497.1\|1201070_1201532_-	DUF3592 domain-containing protein	NA	NA	NA	NA
WP_000759309.1\|1201589_1202636_-	spermidine/putrescine ABC transporter substrate-binding protein PotD	NA	NA	NA	NA
WP_000580316.1\|1202632_1203427_-	spermidine/putrescine ABC transporter permease PotC	NA	NA	NA	NA
WP_000074972.1\|1203593_1204712_-\|integrase	tyrosine-type recombinase/integrase	Q77Z04	Phage_21	1.5e-82	43.6
WP_000003742.1\|1204680_1204950_-	excisionase	NA	NA	NA	NA
WP_032284903.1\|1205011_1207456_-	exonuclease	V5UQJ3	Shigella_phage	4.2e-175	57.9
WP_000092784.1\|1207548_1207737_-	DUF1482 family protein	NA	NA	NA	NA
WP_000450222.1\|1207733_1207922_-	cell division inhibitor	NA	NA	NA	NA
WP_000559920.1\|1208450_1208966_+	hypothetical protein	NA	NA	NA	NA
WP_000367379.1\|1209079_1209232_-	DUF1391 family protein	M4QQ57	Salicola_phage	1.1e-06	53.2
WP_001303511.1\|1209522_1209801_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_001302048.1\|1209802_1209994_-	hypothetical protein	NA	NA	NA	NA
WP_001169685.1\|1210014_1210386_-	hypothetical protein	NA	NA	NA	NA
WP_032279888.1\|1210482_1210785_+	transcriptional regulator	K7PHA1	Enterobacteria_phage	1.1e-05	34.8
WP_000693925.1\|1210781_1211207_+	Rha family transcriptional regulator	NA	NA	NA	NA
WP_044527394.1\|1211275_1212307_+	phage replisome organiser	A0A0U2RT81	Escherichia_phage	6.9e-87	70.4
WP_072130322.1\|1212218_1212761_+	replication protein	A0A0U2JGJ0	Escherichia_phage	3.6e-79	90.2
WP_106879105.1\|1212794_1213511_+	DUF1627 domain-containing protein	A0A0U2SAW4	Escherichia_phage	6.0e-74	63.4
WP_000017341.1\|1213507_1213825_+	DNA-binding protein	A0A222YXX1	Escherichia_phage	1.4e-35	75.0
WP_072094475.1\|1213821_1214127_+	DUF4406 domain-containing protein	A0A0U2SAZ1	Escherichia_phage	8.3e-49	92.1
WP_001224672.1\|1214274_1214457_+	hypothetical protein	A0A2R2Z308	Escherichia_phage	2.0e-26	96.7
WP_001289995.1\|1214622_1215138_+	hypothetical protein	A0A076GCN9	Escherichia_phage	9.5e-37	77.6
WP_001398606.1\|1215371_1215584_+	type I toxin-antitoxin system Hok family toxin	A0A0U2QV81	Escherichia_phage	1.2e-25	90.0
WP_001219083.1\|1215828_1216188_+	helix-turn-helix transcriptional regulator	L7TKV7	Pseudomonas_virus	2.7e-22	50.0
WP_000284536.1\|1216190_1216667_+	ImmA/IrrE family metallo-endopeptidase	L7THB5	Pseudomonas_virus	1.7e-16	33.3
WP_024200925.1\|1217099_1217378_+	hypothetical protein	I6PCV7	Cronobacter_phage	3.7e-11	48.4
WP_050868115.1\|1217379_1218429_+	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	1.9e-116	58.7
WP_001204796.1\|1218446_1218839_+	antitermination protein Q	Q5MBW8	Stx1-converting_phage	4.7e-36	62.7
WP_001005105.1\|1218905_1219523_+	hypothetical protein	NA	NA	NA	NA
WP_000917741.1\|1219758_1219956_+	hypothetical protein	A0A0P0ZDH6	Stx2-converting_phage	8.0e-29	100.0
WP_106879106.1\|1220106_1221165_+	site-specific DNA-methyltransferase	A0A0N7KZF8	Stx2-converting_phage	4.0e-207	99.1
WP_050864278.1\|1221548_1222508_+	Shiga toxin Stx2a subunit A	Q776Q3	Enterobacteria_phage	3.6e-175	99.7
WP_000738072.1\|1222519_1222789_+	Shiga toxin Stx2a subunit B	Q6DWN4	Enterobacteria_phage	1.2e-43	100.0
WP_064549419.1\|1223290_1225228_+	SASA family carbohydrate esterase	S5MDQ7	Escherichia_phage	0.0e+00	94.2
WP_000143458.1\|1225365_1225545_+	DUF1378 family protein	A0A2R2Z345	Escherichia_phage	2.2e-25	100.0
WP_001290230.1\|1225585_1225831_+	DUF826 domain-containing protein	A0A0P0ZGR2	Escherichia_phage	8.8e-17	100.0
WP_000284506.1\|1225908_1226124_+\|holin	holin	Q9ZWW2	Enterobacteria_phage	6.9e-34	100.0
WP_039264424.1\|1226127_1226919_+	DUF1327 domain-containing protein	Q08JA0	Stx2-converting_phage	4.0e-34	86.7
WP_001092874.1\|1227430_1227964_+	lysozyme	Q6H9V6	Enterobacteria_phage	1.4e-99	95.5
WP_001056888.1\|1228238_1228811_+	hypothetical protein	A0A088CD55	Shigella_phage	9.0e-97	88.4
WP_000443009.1\|1228810_1228960_+	hypothetical protein	A0A0P0ZG36	Escherichia_phage	6.7e-12	79.6
WP_032209690.1\|1228962_1229400_+\|lysis	lysis protein	A0A0P0ZFH2	Escherichia_phage	4.7e-69	97.9
WP_001109017.1\|1229602_1230145_+	hypothetical protein	A0A088CBJ5	Shigella_phage	4.1e-99	98.9
WP_001405844.1\|1230855_1231362_+	DNA-packaging protein	O64316	Escherichia_phage	1.6e-33	48.5
WP_001499025.1\|1231333_1233262_+\|terminase	phage terminase large subunit family protein	A0A0K2FJ14	Enterobacteria_phage	3.7e-259	65.7
WP_000259002.1\|1233245_1233452_+\|head,tail	head-tail joining protein	K7PM10	Enterobacteria_phage	7.9e-11	56.9
WP_001398667.1\|1233448_1235041_+\|portal	phage portal protein	K7P6U7	Enterobacteria_phage	1.5e-186	61.6
WP_001253971.1\|1235030_1236536_+	S49 family peptidase	A0A2I6TC87	Escherichia_phage	4.6e-100	52.6
1236444:1236461	attL	NA	NA	NA	NA
WP_000256813.1\|1236571_1236919_+\|head	head decoration protein	A0A2R9YJN3	Escherichia_phage	2.6e-22	58.1
WP_000522633.1\|1236976_1238005_+\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	6.6e-114	61.9
WP_000201497.1\|1238057_1238441_+	hypothetical protein	NA	NA	NA	NA
WP_001204259.1\|1238433_1238787_+\|tail	tail attachment protein	A0A0K2FJB7	Enterobacteria_phage	2.1e-40	69.2
WP_000974993.1\|1238802_1239378_+\|tail	tail protein	A0A2R9YJK4	Escherichia_phage	2.9e-50	57.8
WP_000683075.1\|1239374_1239770_+\|tail	tail protein	A0A2R9YJI2	Escherichia_phage	2.2e-57	80.9
WP_106879107.1\|1239777_1240527_+\|tail	phage tail protein	S5M7Q5	Escherichia_phage	1.2e-128	93.2
WP_052903904.1\|1240546_1240978_+\|tail	phage minor tail protein G	A0A0K2FIQ8	Enterobacteria_phage	6.2e-42	66.4
WP_072126353.1\|1241004_1241409_+\|tail	phage tail assembly protein T	S5MDP5	Escherichia_phage	4.5e-42	83.8
WP_106879108.1\|1241389_1243969_+\|tail	phage tail tape measure protein	A0A2R9YJM8	Escherichia_phage	0.0e+00	78.0
WP_000847279.1\|1243965_1244295_+\|tail	phage tail protein	S5MW28	Escherichia_phage	5.6e-59	100.0
WP_106879109.1\|1244294_1244993_+\|tail	phage minor tail protein L	Q6H9T5	Enterobacteria_phage	1.8e-131	98.3
WP_044808579.1\|1245003_1245747_+\|tail	phage tail protein	S5MQI8	Escherichia_phage	5.9e-149	98.0
WP_136755463.1\|1245692_1246325_+\|tail	tail assembly protein	Q9EYE5	Enterobacteria_phage	2.1e-99	89.5
WP_000078853.1\|1251122_1251263_+	Hok/Gef family protein	S5M7Q0	Escherichia_phage	2.9e-17	95.7
WP_000438829.1\|1253129_1253342_+	hypothetical protein	NA	NA	NA	NA
WP_001373129.1\|1253353_1254028_+	DUF4376 domain-containing protein	S5MBX6	Escherichia_phage	3.3e-114	90.1
WP_022581964.1\|1254190_1254520_-	YkgJ family cysteine cluster protein	NA	NA	NA	NA
WP_000799399.1\|1254683_1255547_-	spermidine/putrescine ABC transporter permease PotB	Q6GZ02	Mycoplasma_phage	6.7e-11	28.7
WP_000531594.1\|1255530_1256667_-	spermidine/putrescine ABC transporter ATP-binding protein PotA	Q6GZ03	Mycoplasma_phage	5.5e-29	39.8
WP_000359461.1\|1256916_1258146_+	peptidase T	NA	NA	NA	NA
WP_001295435.1\|1258291_1259413_-	cupin domain-containing protein	NA	NA	NA	NA
WP_032326825.1\|1259661_1260891_+\|integrase	site-specific integrase	A0A2H4JB45	uncultured_Caudovirales_phage	1.5e-133	55.9
WP_000953271.1\|1261265_1261454_+	AlpA family transcriptional regulator	A0A2H4JB58	uncultured_Caudovirales_phage	5.9e-13	64.2
WP_000182306.1\|1261697_1261901_-	hypothetical protein	NA	NA	NA	NA
WP_000103621.1\|1261958_1262138_-	hypothetical protein	A0A2H4JB52	uncultured_Caudovirales_phage	1.5e-10	58.6
WP_000190551.1\|1262643_1262823_-	hypothetical protein	NA	NA	NA	NA
WP_106879110.1\|1263015_1263213_+	host cell division inhibitor Icd-like protein	NA	NA	NA	NA
WP_047091603.1\|1263205_1263418_+	hypothetical protein	NA	NA	NA	NA
WP_106879111.1\|1263407_1263872_+	hypothetical protein	NA	NA	NA	NA
WP_047091601.1\|1263864_1264098_+	hypothetical protein	NA	NA	NA	NA
WP_000770163.1\|1264103_1264403_+	DUF4222 domain-containing protein	NA	NA	NA	NA
WP_106879112.1\|1264399_1265806_+	AAA family ATPase	A0A2H4JFA4	uncultured_Caudovirales_phage	1.8e-114	60.1
WP_032307310.1\|1266007_1266259_+	hypothetical protein	NA	NA	NA	NA
WP_032307311.1\|1266255_1266678_+	single-stranded DNA-binding protein	NA	NA	NA	NA
WP_032308115.1\|1267095_1267302_+	hypothetical protein	NA	NA	NA	NA
WP_032308116.1\|1267301_1268357_+\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	3.5e-70	43.4
WP_000380882.1\|1268368_1268704_+\|head	head decoration protein	NA	NA	NA	NA
WP_032308117.1\|1268716_1269130_+	hypothetical protein	NA	NA	NA	NA
WP_000835281.1\|1269335_1269878_+\|terminase	terminase	O64316	Escherichia_phage	1.8e-33	44.2
WP_000133424.1\|1270133_1270415_+	hypothetical protein	NA	NA	NA	NA
WP_000735412.1\|1271016_1272477_-	two-component system sensor histidine kinase PhoQ	NA	NA	NA	NA
WP_001265481.1\|1272476_1273148_-	two-component system response regulator PhoP	NA	NA	NA	NA
WP_000423750.1\|1273315_1274686_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	5.5e-108	44.9
WP_001297479.1\|1274689_1275331_-	high frequency lysogenization protein HflD	NA	NA	NA	NA
WP_001297484.1\|1275366_1276473_-\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
1275567:1275584	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1380054 : 1450432

Escherichia_phage(27.78%)

tail,holin,protease,lysis,capsid,portal,transposase,terminase,head,integrase

attL 1379876:1379903|attR 1436627:1436654

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1379876:1379903	attL	NA	NA	NA	NA
WP_000113693.1\|1380054_1381185_-\|integrase	tyrosine-type recombinase/integrase	O21940	Phage_21	4.0e-104	51.4
WP_000113183.1\|1381162_1381411_-	excisionase	NA	NA	NA	NA
WP_106879115.1\|1381475_1382531_-	exonuclease	A0A192Y6E0	Salmonella_phage	5.4e-55	56.0
WP_089538410.1\|1382546_1383702_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.8e-67	44.7
WP_000092839.1\|1385309_1385498_-	DUF1482 family protein	NA	NA	NA	NA
WP_000450222.1\|1385494_1385683_-	cell division inhibitor	NA	NA	NA	NA
WP_001365839.1\|1386457_1386826_-	hypothetical protein	NA	NA	NA	NA
WP_000380317.1\|1386837_1386990_-	DUF1391 family protein	M4QQ57	Salicola_phage	5.1e-07	53.2
WP_001003380.1\|1387179_1387587_-	helix-turn-helix domain-containing protein	I6PD69	Cronobacter_phage	5.5e-24	45.4
WP_000476991.1\|1387664_1387892_+	transcriptional regulator	NA	NA	NA	NA
WP_000705131.1\|1387875_1388397_+	hypothetical protein	NA	NA	NA	NA
WP_000054520.1\|1388377_1389343_+	hypothetical protein	U5P0A0	Shigella_phage	5.0e-55	61.2
WP_000790460.1\|1389349_1390090_+	ATP-binding protein	A0A088CBP4	Shigella_phage	4.7e-114	83.1
WP_000450858.1\|1390119_1390881_+	DUF1627 domain-containing protein	A0A088CE47	Shigella_phage	8.4e-74	64.0
WP_000215513.1\|1390940_1391135_+	hypothetical protein	NA	NA	NA	NA
WP_000211993.1\|1391476_1392028_+	ORF6N domain-containing protein	A0A0N7C203	Escherichia_phage	5.5e-43	53.3
WP_000882661.1\|1392242_1392455_+	type I toxin-antitoxin system Hok family toxin	A0A0U2QV81	Escherichia_phage	5.6e-28	94.3
WP_000042395.1\|1392557_1392875_-	DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_001452497.1\|1393463_1393691_+	hypothetical protein	NA	NA	NA	NA
WP_024199763.1\|1393744_1394014_+	hypothetical protein	I6PCV7	Cronobacter_phage	1.2e-11	52.5
WP_050877448.1\|1394015_1395065_+	DUF968 domain-containing protein	U5P0K4	Shigella_phage	4.5e-110	54.3
WP_000904164.1\|1395077_1395440_+	RusA family crossover junction endodeoxyribonuclease	V5URS4	Shigella_phage	2.4e-34	61.9
WP_001064918.1\|1395432_1396098_+	antiterminator	I6PDF8	Cronobacter_phage	1.6e-60	52.0
WP_000342737.1\|1396351_1397065_+	hypothetical protein	NA	NA	NA	NA
WP_000917733.1\|1397238_1397436_+	hypothetical protein	S5MQK8	Escherichia_phage	6.8e-28	96.9
WP_064579144.1\|1397586_1398645_+	site-specific DNA-methyltransferase	S5MDR0	Escherichia_phage	4.4e-206	98.6
WP_000271629.1\|1399125_1399554_+	cell envelope integrity protein TolA	NA	NA	NA	NA
WP_000382067.1\|1400250_1400976_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_062878147.1\|1402840_1404805_+	SASA family carbohydrate esterase	A0A0P0ZBH7	Stx2-converting_phage	8.0e-294	78.3
WP_000142780.1\|1404939_1405119_+	DUF1378 family protein	A0A2R2Z345	Escherichia_phage	5.4e-24	93.2
WP_001290230.1\|1405159_1405405_+	DUF826 domain-containing protein	A0A0P0ZGR2	Escherichia_phage	8.8e-17	100.0
WP_000284506.1\|1405482_1405698_+\|holin	holin	Q9ZWW2	Enterobacteria_phage	6.9e-34	100.0
WP_039264424.1\|1405701_1406493_+	DUF1327 domain-containing protein	Q08JA0	Stx2-converting_phage	4.0e-34	86.7
WP_001092874.1\|1407004_1407538_+	lysozyme	Q6H9V6	Enterobacteria_phage	1.4e-99	95.5
WP_072024677.1\|1407694_1407877_+	hypothetical protein	NA	NA	NA	NA
WP_024173692.1\|1408025_1408493_+\|lysis	lysis protein	A0A0H4IT10	Shigella_phage	7.9e-67	87.1
WP_000877795.1\|1408673_1409219_+	hypothetical protein	A0A0P0ZFJ1	Escherichia_phage	7.4e-64	68.6
WP_000828070.1\|1409555_1409882_+	TonB family protein	H6WZK5	Escherichia_phage	6.3e-55	98.1
WP_000095744.1\|1410013_1410214_-	YlcI/YnfO family protein	H6WZK6	Escherichia_phage	1.3e-29	97.0
WP_000829191.1\|1410255_1410621_+	HNH endonuclease	B6ETE5	Enterobacteria_phage	1.0e-61	95.9
WP_000958387.1\|1410909_1411473_+\|terminase	terminase small subunit	A0A0N7KZJ8	Stx2-converting_phage	8.1e-90	100.0
WP_001373204.1\|1411469_1413131_+\|terminase	terminase large subunit	Q6H9U9	Enterobacteria_phage	0.0e+00	99.5
WP_000172990.1\|1413194_1415132_+\|capsid	phage major capsid protein	Q6H9U8	Enterobacteria_phage	0.0e+00	99.7
WP_001063099.1\|1415176_1415398_+	hypothetical protein	B6DZA0	Enterobacteria_phage	5.8e-36	100.0
WP_001365916.1\|1415343_1417929_+\|portal	phage portal protein	B6DZA1	Enterobacteria_phage	0.0e+00	96.3
WP_000126028.1\|1417925_1418252_+\|head,tail	phage gp6-like head-tail connector protein	B6ETF0	Enterobacteria_phage	3.9e-52	97.2
WP_001007902.1\|1418262_1418613_+\|head	phage head closure protein	A0A0P0ZCU6	Stx2-converting_phage	2.0e-59	99.1
WP_000573397.1\|1418609_1419056_+	HK97 gp10 family phage protein	A0A0N7KZI9	Stx2-converting_phage	2.0e-75	99.3
WP_000133383.1\|1419052_1419397_+	DUF3168 domain-containing protein	A0A0P0ZC17	Stx2-converting_phage	4.2e-57	99.1
WP_001275414.1\|1419463_1420180_+\|tail	tail protein	A0A0P0ZDV1	Stx2-converting_phage	1.5e-125	98.7
WP_000710936.1\|1420194_1420569_+\|tail	tail assembly protein	A0A0P0ZE84	Stx2-converting_phage	3.9e-64	98.4
WP_122993267.1\|1420664_1420874_+	DUF4035 domain-containing protein	H6WZM0	Escherichia_phage	1.5e-33	98.6
WP_000212873.1\|1420922_1424165_+\|tail	phage tail tape measure protein	A0A0P0ZCJ4	Stx2-converting_phage	0.0e+00	89.5
WP_000343408.1\|1424157_1424499_+\|tail	phage tail protein	A0A0P0ZDL9	Stx2-converting_phage	7.6e-51	81.2
WP_000738904.1\|1424697_1425861_+	porin OmpC	Q1MVN1	Enterobacteria_phage	1.6e-140	66.9
WP_106879109.1\|1426071_1426770_+\|tail	phage minor tail protein L	Q6H9T5	Enterobacteria_phage	1.8e-131	98.3
WP_050878055.1\|1426780_1427524_+\|tail	phage tail protein	S5MQI8	Escherichia_phage	3.7e-143	95.1
WP_135301496.1\|1427469_1428102_+\|tail	tail assembly protein	Q9EYE5	Enterobacteria_phage	6.7e-101	91.0
WP_106879117.1\|1429011_1432698_+	DUF1983 domain-containing protein	S5MW25	Escherichia_phage	0.0e+00	87.9
WP_000078853.1\|1432896_1433037_+	Hok/Gef family protein	S5M7Q0	Escherichia_phage	2.9e-17	95.7
WP_000290874.1\|1433181_1434450_+\|tail	phage tail protein	S5MDN9	Escherichia_phage	6.5e-55	99.1
WP_001049904.1\|1434518_1435190_+	DUF4376 domain-containing protein	S5MBX6	Escherichia_phage	9.6e-106	83.4
WP_000211405.1\|1435597_1436158_-	ORF6N domain-containing protein	A0A0P0ZC44	Stx2-converting_phage	5.4e-54	69.8
WP_001079509.1\|1436804_1437311_-	ferritin-like domain-containing protein	NA	NA	NA	NA
1436627:1436654	attR	NA	NA	NA	NA
WP_001056491.1\|1437356_1437857_-	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_000807651.1\|1437942_1438122_-	general stress protein	NA	NA	NA	NA
WP_000443067.1\|1438502_1439309_-	tryptophan synthase subunit alpha	NA	NA	NA	NA
WP_000209520.1\|1439308_1440502_-	tryptophan synthase subunit beta	NA	NA	NA	NA
WP_001297118.1\|1440513_1441872_-	bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF	A0A0P0IR83	Acinetobacter_phage	8.6e-37	40.7
WP_000763511.1\|1441875_1443471_-	bifunctional anthranilate synthase glutamate amidotransferase component TrpG/anthranilate phosphoribosyltransferase TrpD	A0A0N7IRD9	Acinetobacter_phage	3.8e-52	38.5
WP_001194590.1\|1443470_1445033_-	anthranilate synthase component I	NA	NA	NA	NA
WP_001700591.1\|1445124_1445169_-	trp operon leader peptide	NA	NA	NA	NA
WP_001285661.1\|1445306_1446188_+	5'-3' exoribonuclease	NA	NA	NA	NA
WP_001295575.1\|1446184_1446805_+	threonylcarbamoyl-AMP synthase	NA	NA	NA	NA
WP_001291216.1\|1446905_1447778_+	23S rRNA pseudouridine(2605) synthase RluB	NA	NA	NA	NA
WP_001278904.1\|1447817_1448408_-	cob(I)yrinic acid a,c-diamide adenosyltransferase	NA	NA	NA	NA
WP_000559283.1\|1448404_1449163_-	YciK family oxidoreductase	A0A0N9R355	Chrysochromulina_ericina_virus	8.8e-07	23.4
WP_000422045.1\|1449382_1450432_+\|protease	protease SohB	A0A2H4UUF9	Bodo_saltans_virus	1.3e-21	31.5

DBSCAN-SWA_6

2288549 : 2297990

Enterobacteria_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001292774.1\|2288549_2289686_+	VWA domain-containing protein	Q9EYF7	Enterobacteria_phage	1.1e-162	97.7
WP_001356047.1\|2289682_2291683_+	hypothetical protein	Q9EYF6	Enterobacteria_phage	0.0e+00	95.5
WP_001295429.1\|2291807_2292269_+	YehR family lipoprotein	Q9EYF5	Enterobacteria_phage	1.9e-76	100.0
WP_000950409.1\|2292308_2292779_-	DUF1456 family protein	Q9EYF4	Enterobacteria_phage	5.2e-82	100.0
WP_000598641.1\|2292825_2293545_-	two-component system response regulator BtsR	NA	NA	NA	NA
WP_001295431.1\|2293541_2295227_-	two-component regulatory system sensor histidine kinase BtsS	Q9EYF3	Enterobacteria_phage	2.5e-304	99.6
WP_001240401.1\|2295448_2296180_+	HTH-type transcriptional regulator MlrA	Q9EYF2	Enterobacteria_phage	9.7e-112	99.5
WP_001216961.1\|2296239_2296347_+	protein YohO	NA	NA	NA	NA
WP_000783120.1\|2296327_2297059_-	glycine betaine ABC transporter permease YehW	NA	NA	NA	NA
WP_000569329.1\|2297063_2297990_-	glycine betaine ABC transporter ATP binding protein YehX	G3M9Y6	Bacillus_virus	2.8e-23	30.8

DBSCAN-SWA_7

2796639 : 2804402

Escherichia_phage(66.67%)

transposase,integrase

attL 2794427:2794440|attR 2801539:2801552

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2794427:2794440	attL	NA	NA	NA	NA
WP_000162574.1\|2796639_2797122_+	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	4.0e-29	46.8
WP_001341819.1\|2797864_2799094_+\|integrase	tyrosine-type recombinase/integrase	A0A1B5FPC6	Escherichia_phage	1.5e-234	100.0
WP_000448925.1\|2799132_2799549_+	hypothetical protein	A0A1B5FPM5	Escherichia_phage	1.1e-72	100.0
WP_000214990.1\|2799619_2801368_-	hypothetical protein	A0A1B5FPH1	Escherichia_phage	0.0e+00	99.8
WP_000577258.1\|2801369_2803088_-	ATP-binding protein	A0A1B5FPD5	Escherichia_phage	5.2e-305	95.5
2801539:2801552	attR	NA	NA	NA	NA
WP_085947771.1\|2803239_2804402_-\|transposase	IS3-like element IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.1e-51	40.6

DBSCAN-SWA_8

2876793 : 2883933

Escherichia_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001272897.1\|2876793_2879355_+	DNA mismatch repair protein MutS	E3T5Q7	Cafeteria_roenbergensis_virus	1.3e-30	20.6
WP_001141325.1\|2879460_2880117_+	protein-serine/threonine phosphatase	A0A222YWF0	Escherichia_phage	1.6e-49	46.3
WP_001297141.1\|2880167_2880935_-	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	3.3e-70	56.7
WP_000847985.1\|2881130_2882039_+	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	3.0e-118	76.9
WP_000590397.1\|2882035_2883298_+	3-oxo-tetronate kinase	A0A077SLJ7	Escherichia_phage	1.3e-135	61.4
WP_001278994.1\|2883294_2883933_+	aldolase	A0A077SK32	Escherichia_phage	1.4e-82	75.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP027372

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

13393 : 18565

Cronobacter_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000086114.1\|13393_14077_-	DNA methylase	A0A2I7RE86	Vibrio_phage	5.1e-30	37.4
WP_032236829.1\|14153_14459_-	hypothetical protein	NA	NA	NA	NA
WP_001373099.1\|14462_15365_-	DUF1281 domain-containing protein	NA	NA	NA	NA
WP_000618108.1\|15783_16032_+	DinI-like family protein	Q2A098	Sodalis_phage	4.1e-14	46.7
WP_000109075.1\|16028_16481_+	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A218MND2	uncultured_virus	1.1e-25	52.0
WP_001365565.1\|16464_17457_+	translesion error-prone DNA polymerase V subunit UmuC	F1C5A5	Cronobacter_phage	8.0e-101	59.5
WP_001373062.1\|17486_17735_+	DUF4113 domain-containing protein	F1C5A5	Cronobacter_phage	1.7e-20	58.8
WP_000587689.1\|17938_18565_+	ParA family plasmid-partitioning AAA ATPase	E5FFJ3	Burkholderia_phage	2.0e-17	31.1

DBSCAN-SWA_2

27837 : 34348

Stx2-converting_phage(57.14%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000422741.1\|27837_28263_+	IS66 family insertion sequence hypothetical protein	Q6H9S5	Enterobacteria_phage	1.5e-48	99.0
WP_000624722.1\|28259_28610_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	4.7e-40	66.4
WP_000080195.1\|28640_30254_+\|transposase	IS66-like element ISEc23 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.0e-182	63.6
WP_001373091.1\|30364_30829_+	IS66 family insertion sequence hypothetical protein	Q6H9S5	Enterobacteria_phage	3.2e-44	89.7
WP_000950104.1\|30780_31131_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	3.1e-39	65.5
WP_000080210.1\|31161_32754_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.9e-174	61.8
WP_001278809.1\|32958_33375_-	recombinase	NA	NA	NA	NA
WP_000688510.1\|33367_34348_-	Plasmid segregation protein parM	A0A0A7NPX4	Enterobacteria_phage	1.7e-79	51.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP027371

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP027372

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection