CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP028102	Fusobacterium mortiferum ATCC 9817 chromosome, complete genome	3 crisprs	cas14j,csm6,csa3,cas3,cas4,DEDDh,DinG,WYL,cas6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas2,cas1	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028102_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028102_1

427012-427105

Orphan

Consensus_repeat	Method
AATTATAACCTACTCCATTACTTCCTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP028102_1

>merge|NZ_CP028102|1|427012-427105|CRISPRCasFinder
AATTATAACCTACTCCATTACTTCCTATATTTTGCCCATAATTTCCTTTATTATGTATTAATCCAAAATTATAACCTATTCCATTACTTCCTAT

>NZ_CP028102|1|1|427012-427105|CRISPRCasFinder
AATTATAACCTACTCCATTACTTCCTAT	ATTTTGCCCATAATTTCCTTTATTATGTATTAATCCAA
AATTATAACCTATTCCATTACTTCCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028102.1\|WP_005885859.1\|415659_416631_-\|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	unknown	unknown	gnl\|CDD\|211689
NZ_CP028102.1\|WP_005885851.1\|419816_421313_-\|ribose-ABC-transporter-ATP-binding-protein-RbsA	unknown	unknown	gnl\|CDD\|236755
NZ_CP028102.1\|WP_005885849.1\|421321_421729_-\|D-ribose-pyranase	unknown	unknown	gnl\|CDD\|183318
NZ_CP028102.1\|WP_005885833.1\|429850_430150_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005885835.1\|429371_429746_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350620
NZ_CP028102.1\|WP_005885829.1\|430289_431096_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|236153
NZ_CP028102.1\|WP_005885823.1\|433932_434283_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP028102.1\|WP_005885821.1\|434907_435819_-\|ATPase	unknown	unknown	gnl\|CDD\|379051
NZ_CP028102.1\|WP_005885857.1\|416746_417664_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188641
NZ_CP028102.1\|WP_005885846.1\|422639_423596_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP028102.1\|WP_005885837.1\|428747_428930_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005885848.1\|421715_422639_-\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NZ_CP028102.1\|WP_005885841.1\|428090_428396_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP028102.1\|WP_005885853.1\|418896_419823_-\|ribose-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|181922
NZ_CP028102.1\|WP_005885826.1\|432288_433638_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224292
NZ_CP028102.1\|WP_005885839.1\|428419_428638_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005885828.1\|431106_432069_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379352
NZ_CP028102.1\|WP_005885861.1\|414836_415667_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223803
NZ_CP028102.1\|WP_005885845.1\|423776_424202_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005885855.1\|418007_418880_-\|ribose-ABC-transporter-substrate-binding-protein-RbsB	unknown	unknown	gnl\|CDD\|182620

Protein	Function_ID	Function_description	E-value
NZ_CP028102.1\|WP_005885859.1\|415659_416631_-\|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	1.26313e-121
NZ_CP028102.1\|WP_005885851.1\|419816_421313_-\|ribose-ABC-transporter-ATP-binding-protein-RbsA	gnl\|CDD\|236755	PRK10762, PRK10762, D-ribose transporter ATP binding protein; Provisional.	0
NZ_CP028102.1\|WP_005885849.1\|421321_421729_-\|D-ribose-pyranase	gnl\|CDD\|183318	PRK11797, PRK11797, D-ribose pyranase; Provisional.	9.67047e-74
NZ_CP028102.1\|WP_005885826.1\|432288_433638_-\|ATP-binding-protein	gnl\|CDD\|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	2.23211e-22
NZ_CP028102.1\|WP_005885829.1\|430289_431096_-\|ATP-binding-protein	gnl\|CDD\|236153	PRK08116, PRK08116, hypothetical protein; Validated.	2.28943e-54
NZ_CP028102.1\|WP_005885823.1\|433932_434283_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	5.73392e-41
NZ_CP028102.1\|WP_005885857.1\|416746_417664_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188641	cd00954, NAL, N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL). N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL), which catalyses the reversible aldol reaction of N-acetyl-D-mannosamine and pyruvate to give N-acetyl-D-neuraminic acid (D-sialic acid). It has a widespread application as biocatalyst for the synthesis of sialic acid and its derivatives. This enzyme has been shown to be quite specific for pyruvate as the donor, but flexible to a variety of D- and, to some extent, L-hexoses and pentoses as acceptor substrates. NAL is member of dihydrodipicolinate synthase family that comprises several pyruvate-dependent class I aldolases.	4.93792e-107
NZ_CP028102.1\|WP_005885835.1\|429371_429746_-\|hypothetical-protein	gnl\|CDD\|350620	cd14845, L-Ala-D-Glu_peptidase_like, L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase. This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.	4.3581e-11
NZ_CP028102.1\|WP_005885855.1\|418007_418880_-\|ribose-ABC-transporter-substrate-binding-protein-RbsB	gnl\|CDD\|182620	PRK10653, PRK10653, ribose ABC transporter substrate-binding protein RbsB.	1.23254e-141
NZ_CP028102.1\|WP_005885853.1\|418896_419823_-\|ribose-ABC-transporter-permease	gnl\|CDD\|181922	PRK09512, rbsC, ribose ABC transporter permease protein; Reviewed.	1.52583e-132
NZ_CP028102.1\|WP_005885821.1\|434907_435819_-\|ATPase	gnl\|CDD\|379051	pfam13177, DNA_pol3_delta2, DNA polymerase III, delta subunit. DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.	6.00302e-46
NZ_CP028102.1\|WP_005885848.1\|421715_422639_-\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	1.50899e-139
NZ_CP028102.1\|WP_005885828.1\|431106_432069_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379352	pfam13730, HTH_36, Helix-turn-helix domain.	5.16874e-13
NZ_CP028102.1\|WP_005885861.1\|414836_415667_-\|radical-SAM-protein	gnl\|CDD\|223803	COG0731, COG0731, Fe-S oxidoreductases [Energy production and conversion].	1.43229e-66
NZ_CP028102.1\|WP_005885846.1\|422639_423596_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.08582e-81
NZ_CP028102.1\|WP_005885841.1\|428090_428396_-\|DNA-binding-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	0.00330282

>NZ_CP028102.1|WP_005885845.1|423776_424202_-|hypothetical-protein
MVSHKTLIIYFFIWRNSGIVIMVRMEKTYIRKREKKYAIYSLFDKKRLTKYYDNIEELEENVYIAKDEKTGKFAFLSSRFSTKTEYKEIIKVLDTEINEYLYIGIVAEEERTDILTKIDKINIKELSEKEYNKIINLLPKN
>NZ_CP028102.1|WP_005885846.1|422639_423596_-|LacI-family-DNA-binding-transcriptional-regulator
MKMKDIAKELGLSIATVSRVVNGHTNVNEETKKRVQEFIEKKNYTPNVIAQNLSKMENKTIALLVPNISNPFFATLTNYICKNFNRGGYQIALYNTVESLEQEKEAIKNILGHRIAGVIAILINGDYEENPLTPLLKQKIQVYLVDREFEDSKLPGVFIDNYIGAYKLTKELLERGHRDIALITGNLDFLNARERMRGYIEAHNDMGVEVKEKNIYEGDYLFESGYIAGKKILDSSVTAVFSSNNLMLYGVLKALKEKDKELELACFEKTEFLELLDRNILSCSIPLEIMGEKIYQLFVNKEKRKKIHIEPLLEKRGE
>NZ_CP028102.1|WP_005885848.1|421715_422639_-|ribokinase
MKKVVVVGSINMDLVTRCKRAPKGGETLFGEEFFQVPGGKGANQAVAIGKLGTEVTMLGKVGKDSFGKDLINSMKESGVDARYIEEGEKSTGIAKIIVEENGQNRILVVAGANSEVDKAYIDRYLDVIKECDIVVAQLEIPVEIVAYALAKAKEFGKMTILNPAPARELDDEIIKNSDLIIPNESELALITGMPTETEEEIKKAGEKLLDMGVSNLIVTLGSKGSLHLNREVCEFHSAYKVKAIDTTAAGDSFIGGLVRELKDNNVGEAIEFATKVSAIAVTRKGAQTSIPTIEEVENFEGVKNEEK
>NZ_CP028102.1|WP_005885849.1|421321_421729_-|D-ribose-pyranase
MKRSRLLNSELSYEIAKIGHTAHITLCDAGLPIPNGVKRIDLAVEAGLPSFISVLKPILSEMQVEEIVLAEEIKEKNPVMLEKILKSFEEVGMNPNIIWVKHEEFKKITRESEAIVRTGECSPYANVILKSGVVF
>NZ_CP028102.1|WP_005885851.1|419816_421313_-|ribose-ABC-transporter-ATP-binding-protein-RbsA
MNKEIVLRMSDIVKTFPGVKALDGASLNIYKGRVMALMGENGAGKSTLIKVMTGIYNMDSGSLYVGNSKVDFRNVNDSQEKGIAVIHQELNLIPELSITENIFLGRELVNGFGKIDSSLMKSEARVLLDKLNVKENENTLVKELTIGKMQMVEIAKALSQNAKIIVMDEPTDALTDSETESLFKVIRELTAEGKSIVYISHRLKEIPEICDDITIMRDGKFICEAEVKDIDEEFIIRNMVGRTLDEQFPRVKVERGKEILRVENLKNSYVDGVSFSLHEGEILGISGLMGAGRSELVKTIYGHLKKDSGKVFIDGEEKNIRSAKEGIECGIAYVSEDRKGDGLVLGMSVKENMTLSALNFFSTLFKLEHKKEEASVEEYIGKFRVKTPSMEQKIKNLSGGNQQKVAIAKALLTNPKILILDEPTRGVDVGAKKEIYDFINDLKTKGLSIIMISSEMPEIMGLSDRIMVIHNGKVTGEFLAEEATQEKIMRCAVGGKEC
>NZ_CP028102.1|WP_005885853.1|418896_419823_-|ribose-ABC-transporter-permease
MLKKIWSNKPLIGLIIFAVIVSVLNPRFLTHANILNVLRQTSINSIIAIGMTLVILTGGIDLSVGSILAFCGAVMASLLNAGHNPILAFIVTLALGLVFGFFNGFLVSKMKLQAFIVTLVTMTFLRGATLVFTEGKPITVDDGGLLFENIGGGYLFDIPIPIYIMIALFVAGHYLLMHTKFGRYTYAIGGNEEATKLSGINVDKVKMWVYGLCGMLSALAGVILTSRLYSAQPTAGSGYELDAIAAVVLGGTSLAGGVGRVTGTALGALIIGVLGNALNLLNVSSYYQMMIKAIVILIAVLIDRKSNK
>NZ_CP028102.1|WP_005885855.1|418007_418880_-|ribose-ABC-transporter-substrate-binding-protein-RbsB
MKKTMKLFGMAALIMVASTVANAEKIGLVVSTQNNPFFVTLKEGAEAKAKELGHELIVLDSQNDPSKELGNVEDLLIRGVDVLLINPTDSDAVASSVRAANRSKIPVVTLDRAANKGKVVSHVASDNVLGGEMAGNYIVEKLNGAGKVVELEGIPGTTAARDRGEGFNKAVNGKLTTVAKQAADFDRTRGLTVMENILQAQPEIDAVFAHNDEMALGALKAIEASGRDILVVGFDATDDAVASVKEGKMGATVAQKPAEIGAVGVEVADKIIKKEEVPANVPVALELIVK
>NZ_CP028102.1|WP_005885857.1|416746_417664_-|dihydrodipicolinate-synthase-family-protein
MRNLEKYHGVIPAFYACYDKEGNISVEGVKALTRYFIEAGVQGVYVGGSSGECIYQGKEERKLVLETIMKEAQGRLTVIAHVACNNTADSMELAAHAESLGVDAIAAIPPIYFRLPEHAIAKYWNDISSAAPNTDFVIYNIPQLAGVALTPSLYKEMLKNPRVIGVKNSSMPIQDIQTFKAIGGKDTIVFNGPDEQFIGGFMIGAEGGIGGTYGAMPKLFLKALECFKKGDYETARAIQYDVNDIITALCSCKGNMYGVIKATLKINHNIEIGGVRSPLANLVEEDMPKVEAVAKLIRDTEAKYL
>NZ_CP028102.1|WP_005885859.1|415659_416631_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK
MNRKPKVVVLGGGSGISVVLRGLKYLPIDLTAIVSVADDGGSSGALRKEFDSPPPGDLRNVLIALSDVEPIIEDVFQYRFKEESSIGAHPLGNLLIMAMNEITGNIGDAVDRLRKLFNIKAKILPATLEKVFLYAETESGKIVEGESNIPFSKEKIKRVFYKNERKAPLENLKALEEADLVVFGIGSLYTSLIPNLLLKEVKESLKKTKGKVVYVCNAMQQPGETEGYDALAHIEAICEVIGEGIIDEVIVDTVEIPEEILSRYKKQRSDRVLVNKESIKKKGIKVKDRDILEIDSKGMVRHHPYKLAATLYSLIDKWEEFYV
>NZ_CP028102.1|WP_005885861.1|414836_415667_-|radical-SAM-protein
MFKHVFGPVPSRRLGISLGVDLVLPKSCNMNCIFCECGATKKLTLKRERFKDPEEVKEEIKEVLKKIKPDYITFSGSGEPTLSKDIGEIIDWIKEHTDVKVCVITNGLLLEDGKVIEDIKKADLIIPTLNSVDNLIFKKINRPSVESDISQVMGGLRNLSEKYRGEIYIETFIIEGLNDSDEHTERMVKFLKNLKFTKLQLNSLDRPGTEEWVKPASKSTLKRIKDKYIELGIKNVEIVNEMKEVEKKLDVDKELLKNMKEKREYSEKELKKIYNI
>NZ_CP028102.1|WP_005885841.1|428090_428396_-|DNA-binding-protein
MDNKNKRSGRKTGKITVGMNHEEYIFYKLSRLSKVDKKLARAMVRDLGVWTSPKKAAAYLTKYVSTIYEKINSKEIFAKKVGNKYLILTESLILLLEGLDN
>NZ_CP028102.1|WP_005885839.1|428419_428638_-|hypothetical-protein
MEYIKIISGVLAIFIGYHKFILSLLDRKIDKEIWEREKKLLERIEKENRKNLVEGLRRIEERITRIEEKLMR
>NZ_CP028102.1|WP_005885837.1|428747_428930_-|hypothetical-protein
MGKVLDMVIKFVKYFICKWFATRVIERIVILLLEELVKRTDSKLDDRIYQAVFEEVEKEV
>NZ_CP028102.1|WP_005885835.1|429371_429746_-|hypothetical-protein
MNKASVRSKKKLEGVDSRLVLLVGYALAISPVDFFVNEGVRSEKKQKEYYKQGKSKCDGVVNRSKHQDGKAIDVYYVGWESDDSLTDGRWYILIESFKKAGKMLGLKLRFGYDWGWDNPHIELR
>NZ_CP028102.1|WP_005885833.1|429850_430150_-|hypothetical-protein
MSVVTTVQKEIESLKNSIKREKAIESNIFDMTAVIEHIAELKEASEPMAEESPYESYEEWQAAAEKELKGYQSSLATIAENKEILVALETYISEHPEGV
>NZ_CP028102.1|WP_005885829.1|430289_431096_-|ATP-binding-protein
MKCQYCGKEYVKNESEGIEYLPEFIRKHIEYIPSCDCLEKIKEREREEEIRKQQAESIKNRVKKYRDISVVDSKFLKSTFEIADMSEKYMKVALRYAKSFMEKKMDIGIIFYGGVGVGKTFATACIANYLMSRGKSVFVINLGLYLLKLTKEWGQGEMELLKIVENCDLLIIDDFGVEKSLEDKNASWRAEKIYNLIDSRYRCGKPLIISTNLEFDEDEDRCEIARRFSAKGKNRIRDRIVEMCYPIKVEGKSRRKVNKQRFYELLKE
>NZ_CP028102.1|WP_005885828.1|431106_432069_-|helix-turn-helix-domain-containing-protein
MERPSYFAVIPASVRYDERLKPSEKILYAEITALINIKGYCYATNQYFSKLYGVHKNSISIWINNLIKCGYLKVKYVIREIEGQKRQERRIYVVKRKEIKKEIETIQEKIVSESVKEYEEDRILKDEKSEEKEECKEKLEEIAQKNLGDSQKDIIEGTNKKLEKINTSRLVQEDYILHTHSQKESEKFPVIREILEKYNQVGLPSFEFPPDNHIILKAYGELGASGVFKALEIMGESEFVKNNMSVNTIFKLENLKKALNGSFKNRDSRVYFEREKKCEKKEGENEKKRDRELEEFLNSNPDNRDDIPELFSSEELFDRN
>NZ_CP028102.1|WP_005885826.1|432288_433638_-|ATP-binding-protein
MLKRKLYNSLLEWKEKSQGKSALLIDGARRIGKSYLCEEFGKNEYKSYLIIDFGNISREIVDLFENESSNLDLFFIKLSAFYGVQLFRRESLIVFDEVQQFPKARQLIKYLVKDGRYDYIETGSLLSLKRNTENIILPSEEKHIQMYPLDFEEFLWALGDTTTIPFLKMCFDEKKPLGQALHRKVMNDFRQYILVGGMPQAVNEYIATKDFANVDEIKRDILTLYRNDISKFAKGYENKVISIFDEIQSQLSKKEKKYKLSSISKEARYREYEDSFMWLNDAMIVNPCYNSTDPNVGLNLNSDYSTRKCYLMDTGLLVTQTFMDGSYTDNEIYKAILFNKLNINEGMIMENIVAQILRTNGHKLFFYSRYDKENKENNMELDFLIKDKKNIKKLAVIEVKSSTYRQHSSLDKFRKKYSERINNSYILYQKDLMVKDGVIHLPIYMGIFL
>NZ_CP028102.1|WP_005885823.1|433932_434283_+|helix-turn-helix-transcriptional-regulator
MEKIKLSCEMDFTLKLIGGKYKLLILYFLLEDEKKRFNELLSAIGSISKKTLTNQLRELENDGLIQRKIYPEVPPKVEYSLTEKGKSLSDILNLLCEWGEKNLDRDIYEITNPQCK
>NZ_CP028102.1|WP_005885821.1|434907_435819_-|ATPase
MIRDIISNEEVKEFFRNELKLKKDSGTYLFYGSDMSLLMEFALHFAKGLCCETLEGDFCGECNICKRIDKMLYSDLEILDNPDGLKVDEIRELAYKSSSSSYEGNRKIFIIKDISKMKKEASNALLKLIEEPNKGSFFILLNTNLNILPTIKSRSILVKVKKRTAEELEVDNYTYTFFRGNSEDIEKYKLLDIDLESGYSYQEIGKAIKGYEETKELEYKINIYKALRDFINNREYLKLHEKIFFAEEIVRATSDRNIYREIVSYIVDIMGYLNGLEERLTMKSMLRFPINMKVFFINLFLEL

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Crispr_ID: NZ_CP028102_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028102_2

2393871-2394225

TypeIII

Consensus_repeat	Method
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	CRISPRCasFinder
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	CRT
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	PILER-CR

4 spacers

cas6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas2

The CRISPR arrays of NZ_CP028102_2

>merge|NZ_CP028102|2|2393871-2394225|CRISPRCasFinder,CRT,PILER-CR
TTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACAGAGAGATATTTCTTACTTAAGTATTTCCATATCAAGACTGATGGTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACAAGAAATAAGCATAGGTTTGTATCTAGATAGTAAAACATATTTAGTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACGTACAGATATGACAGCTCTTAAAGGAAGTTCTCAATTAGAGAAGTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACATTGAACTATATATAAAATAAGGTGATAATATGAATAATGTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC

>NZ_CP028102|2|2|2393871-2394225|CRISPRCasFinder
TTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	AGAGAGATATTTCTTACTTAAGTATTTCCATATCAAGACTGATG
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	AAGAAATAAGCATAGGTTTGTATCTAGATAGTAAAACATATTTA
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	GTACAGATATGACAGCTCTTAAAGGAAGTTCTCAATTAGAGAA
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	ATTGAACTATATATAAAATAAGGTGATAATATGAATAAT
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC

>NZ_CP028102|2|1|2393871-2394225|CRT
TTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	AGAGAGATATTTCTTACTTAAGTATTTCCATATCAAGACTGATG
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	AAGAAATAAGCATAGGTTTGTATCTAGATAGTAAAACATATTTA
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	GTACAGATATGACAGCTCTTAAAGGAAGTTCTCAATTAGAGAA
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC	ATTGAACTATATATAAAATAAGGTGATAATATGAATAAT
GTTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC

>NZ_CP028102|2|1|2393872-2394225|PILER-CR
TTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACA	GAGAGATATTTCTTACTTAAGTATTTCCATATCAAGACTGATGG
TTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACA	AGAAATAAGCATAGGTTTGTATCTAGATAGTAAAACATATTTAG
TTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACG	TACAGATATGACAGCTCTTAAAGGAAGTTCTCAATTAGAGAAG
TTTCAATCCTTATTGTTACTGGTCTTATCTTTTAACA	TTGAACTATATATAAAATAAGGTGATAATATGAATAATG
TTTCAATCCTTATTGTTACTGGTCTTATCTTTTAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028102.1\|WP_005886898.1\|2397292_2397988_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NZ_CP028102.1\|WP_040494122.1\|2392547_2392925_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP028102.1\|WP_005886892.1\|2400855_2401500_-\|CRISPR-associated-endonuclease-Cas6	cas6	cls000004_cas6_CAS-I:CAS-III	gnl\|CDD\|379957
NZ_CP028102.1\|WP_005886918.1\|2387301_2389281_-\|3-dehydroquinate-synthase	unknown	unknown	gnl\|CDD\|341474
NZ_CP028102.1\|WP_005886920.1\|2386960_2387221_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005886912.1\|2390858_2392103_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP028102.1\|WP_005886910.1\|2392120_2392453_-\|lipoprotein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005886886.1\|2404381_2404672_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP028102.1\|WP_005886914.1\|2390387_2390843_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005886902.1\|2395191_2396343_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	mkCas0182_csm5gr7_CAS-III-A	gnl\|CDD\|224251
NZ_CP028102.1\|WP_005886916.1\|2389536_2390379_+\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|320695
NZ_CP028102.1\|WP_005886904.1\|2394460_2395189_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP028102.1\|WP_081462374.1\|2385907_2386936_-\|selenide,-water-dikinase-SelD	unknown	unknown	gnl\|CDD\|273100
NZ_CP028102.1\|WP_106991862.1\|2384542_2385904_-\|L-seryl-tRNA(Sec)-selenium-transferase	unknown	unknown	gnl\|CDD\|235278
NZ_CP028102.1\|WP_005886894.1\|2398461_2400855_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NZ_CP028102.1\|WP_106991863.1\|2393039_2393855_-\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|319871
NZ_CP028102.1\|WP_005886890.1\|2401508_2403224_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005886896.1\|2398001_2398469_-\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NZ_CP028102.1\|WP_005886900.1\|2396339_2397284_-\|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	gnl\|CDD\|187794
NZ_CP028102.1\|WP_005886888.1\|2404090_2404375_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856

Protein	Function_ID	Function_description	E-value
NZ_CP028102.1\|WP_005886898.1\|2397292_2397988_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.01763e-70
NZ_CP028102.1\|WP_005886904.1\|2394460_2395189_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	0.00102863
NZ_CP028102.1\|WP_005886918.1\|2387301_2389281_-\|3-dehydroquinate-synthase	gnl\|CDD\|341474	cd08195, DHQS, Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis. Dehydroquinate synthase (DHQS) catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) to dehydroquinate (DHQ) in the second step of the shikimate pathway. This pathway, which involves seven sequential enzymatic steps in the conversion of erythrose 4-phosphate and phosphoenolpyruvate into chorismate for subsequent synthesis of aromatic compounds, is found in bacteria, microbial eukaryotes, and plants, but not in mammals. Therefore, enzymes of this pathway are attractive targets for the development of non-toxic antimicrobial compounds, herbicides and anti-parasitic agents. The activity of DHQS requires nicotinamide adenine dinucleotide (NAD) as cofactor. A single active site in DHQS catalyzes five sequential reactions involving alcohol oxidation, phosphate elimination, carbonyl reduction, ring opening, and intramolecular aldol condensation. The binding of substrates and ligands induces domain conformational changes. In some fungi and protozoa, this domain is fused with the other four domains in shikimate pathway and forms a penta-domain AROM protein, which catalyzes steps 2-6 in the shikimate pathway.	1.30568e-149
NZ_CP028102.1\|WP_005886912.1\|2390858_2392103_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.07839e-40
NZ_CP028102.1\|WP_040494122.1\|2392547_2392925_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	2.32822e-30
NZ_CP028102.1\|WP_005886886.1\|2404381_2404672_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	5.66832e-12
NZ_CP028102.1\|WP_005886902.1\|2395191_2396343_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|224251	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.73569e-10
NZ_CP028102.1\|WP_005886916.1\|2389536_2390379_+\|zinc-metalloprotease-HtpX	gnl\|CDD\|320695	cd07336, M48B_HtpX_like, Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase. This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.	7.42009e-159
NZ_CP028102.1\|WP_005886892.1\|2400855_2401500_-\|CRISPR-associated-endonuclease-Cas6	gnl\|CDD\|379957	pfam17262, DUF5328, Family of unknown function (DUF5328). This family of unknown function can be found in Bacteria and Archaea. Some of the proteins in this family are annotated in UniProt as putative DNA repair proteins.	2.13833e-22
NZ_CP028102.1\|WP_081462374.1\|2385907_2386936_-\|selenide,-water-dikinase-SelD	gnl\|CDD\|273100	TIGR00476, selenide_water_dikinase, selenium donor protein. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements: SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3-prime or 5-prime non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This model describes SelD, known as selenophosphate synthetase, selenium donor protein, and selenide,water dikinase. SelD provides reduced selenium for the selenium transferase SelA. This protein itself contains selenocysteine in many species; any sequence scoring well but not aligning to the beginning of the model is likely to have a selenocysteine residue incorrectly interpreted as a stop codon upstream of the given sequence. The SelD protein also provides selenophosphate for the enzyme tRNA 2-selenouridine synthase, which catalyzes a tRNA base modification. It also contributes to selenium incorporation by selenium-dependent molybdenum hydroxylases (SDMH), in genomes with the marker TIGR03309. All genomes with SelD should make selenocysteine, selenouridine, SDMH, or some combination.	9.47319e-148
NZ_CP028102.1\|WP_106991862.1\|2384542_2385904_-\|L-seryl-tRNA(Sec)-selenium-transferase	gnl\|CDD\|235278	PRK04311, PRK04311, selenocysteine synthase; Provisional.	0
NZ_CP028102.1\|WP_005886894.1\|2398461_2400855_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	9.37032e-133
NZ_CP028102.1\|WP_106991863.1\|2393039_2393855_-\|4Fe-4S-binding-protein	gnl\|CDD\|319871	cd10549, MtMvhB_like, Uncharacterized polyferredoxin-like protein. This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.	1.26909e-08
NZ_CP028102.1\|WP_005886896.1\|2398001_2398469_-\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	1.3923e-14
NZ_CP028102.1\|WP_005886900.1\|2396339_2397284_-\|hypothetical-protein	gnl\|CDD\|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.16745e-17
NZ_CP028102.1\|WP_005886888.1\|2404090_2404375_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.07027e-17

>NZ_CP028102.1|WP_106991863.1|2393039_2393855_-|4Fe-4S-binding-protein
MKKVWGMYFSGTGTTEKVVKRIANTLGEKLGVERENIDFTSKSAREKEYIFSKEDIVVFGVPVIAGRVPNLLLKFLDTIRGEGALAVPIVLFGNRNYDDALIELRDILLKDGFFVVGAGAFVGEHSFSRELGKGRPDREDLEIADILAEKVIENMENKKYLSEKLYVKGESPYRWYYQPRDSKGNPIDIRKVKPKTNMELCNNCGLCVELCPLGSIEKERVDVVSGICMKCCACIKKCPQGAKYFDDKNFIYHKEELELEYSRRAKVEIFY
>NZ_CP028102.1|WP_040494122.1|2392547_2392925_-|rhodanese-like-domain-containing-protein
MKRVIIGVLIMINTITNSYGKELAYQIISQEKAKEMMEENNNYIILDVRTDWEYKMGHIAGAINIPNEEIGHQEIEELPDKNQPILVYCRSGHRSKQASSKLAVLGYKNIYEFGGVITWEYGLVE
>NZ_CP028102.1|WP_005886910.1|2392120_2392453_-|lipoprotein
MKKIVKLFVIIMVIVLAGCSNTETQEPPRQRTTGEKVALVTEFIIDNAIYNGYDLGFGREIIKSKSVSQSDSVTTTGIDASGNLNTHTTTKTTTKTKSKGAGFGIGIGDY
>NZ_CP028102.1|WP_005886912.1|2390858_2392103_+|YihY/virulence-factor-BrkB-family-protein
MKLTSLIDSYKEIISQGKLNNIISVSKKALESYKRANSGLWVTSLCFYTILSLVPIFAILFSLGTWFGVADYLLVKLREYSPLNEESINLLITFAQNFLENTRTGILAGIGFLFLGWTLISMFAIIEKAFNDIWRVEKSRMLLRKITDYISFFILFPTLMVISSGIVKIIGNRIGMENLILTIFIKFVPFLTLLFFFTIMYMLIPNTKVRFIPALISAMFIAMFFSGFQSLFLLLQDMVNAYNKIYGSFSVIFIFLFWLKIMWFFIILGSHLCYFLQNRELHLFTKGAEDVNFKIKEYTAVIVMKELIERYYSNLSPLSINEIVKKYDIPYEVVKHILEIFISDELVGEIGDKDEKNYVIIKNIDTISFKTVFKSLENYGEKINFKNSDELESLLDCVREKNFKFSFKEYIEKN
>NZ_CP028102.1|WP_005886914.1|2390387_2390843_+|hypothetical-protein
MKKFFIGIFTMIALLTVKVQGAEIIPEYFLMERLIMLMDVAPTYISNDGKQELKAMQVDKEVMNILGNSENPFYIYDSNNEKKIVRMGDYFYSPTTLSSIYTLDKENFESNFRDKSLPEEKLETTIEKTQDKIDISDIDEGTGVPADENSN
>NZ_CP028102.1|WP_005886916.1|2389536_2390379_+|zinc-metalloprotease-HtpX
MNTLKTFVLMGVLTFILLLLGNAIGGQNGIFIALIMAGFMNFFSYWYSDKIVLSMYGAQPVDKNTHLYQLVEKLAKSADLPMPKVYIINEAQPNAFATGRNPKNAAVAVTRGLMDLVDDYELAGVIGHELGHVHNKDILISTVAATMAGAIAFLANMAKWAAIFGNHRDDEDGGSNPIALIGIAIFAPLAAMLVQMAISRTREYKADRFGAKVSGNPLYLANALRKLDMYSRRIPMPNAAPATENMFIVSPLAGSKMANLFSTHPSTEDRIRKLEEMRYE
>NZ_CP028102.1|WP_005886918.1|2387301_2389281_-|3-dehydroquinate-synthase
MNIIDVKTSSGEYPIILGCNIISELKKYTIPYDKILILSNEDIGDIYFEKLLWELNDERIKTFTIPEGEKFKNLETVSTIYDFMAKENFSRKSLIISLGGGVVCDMGGFVGATYMRGIDFIQVPTSLLAQVDASIGGKTAVDHTRGKNLIGVFKQPKAVLIDVEFLKTLPKEQFSSGMAEVIKHSLLLENRDYFRFLMERREEILSLESSSLIEMIKKSCEIKREIVEKDEFELGERASLNLGHTYGHSLEKLFNFENITHGEAVAKGIVFELELSNILNGIEDEFINEIKDIFRSYGLNSNPIYYPEKILLDVMKKDKKNSFDKINFILFDKNKKVYKDSVEVKNILEVNNLFSSRYIKGIIDIGTNSCRLFLAQVYEDREIKIEKEISKDVEIVKLGEDVNKNGYLKKEAIKRTIDCLKKYKEKADKFGASKVIAFATSATRDSQNREEFLSQVRDIGIDIRCIAGEREAQLNFLGNSIVFKDRILVLDIGGGSTEFTLGENGNIEFTKSINIGAVRGTERFFPEQNYTEENIEECRNWIKEMVSGVKFLKDDNFTLVGVAGTATTQISVQKQMEIYDSSEVHLSKINLDELRQNLQLFLSCDGKKRKEIVGLEAKRADVIIAGTIILIAIMEELGVDSMVVSESDNLNGAMISKEI
>NZ_CP028102.1|WP_005886920.1|2386960_2387221_-|hypothetical-protein
MTPRLAKILDAYDSFNSTTRKRLVAGNLYDYFMQEFRGEIEMIYNSATKEDIKEDVKGMAEIIYKEEEKEKRDFLVGVLVDIVKMM
>NZ_CP028102.1|WP_081462374.1|2385907_2386936_-|selenide,-water-dikinase-SelD
MDKLHLDRCSIGGUASKIGPEVLSEILHDLPSVEDKNLIVGFEKSDDAAVYKLTEDLAIIQTLDFFTPMTDDPYIFGQIAAANSLSDVYAMGGQPKTAMNIVCFPQKMDIKILGEILRGGAEKVMEAGAVLSGGHSIHDPEVKYGLSVTGIAHPDKILKNHGCENGDILICTKKLGTGIVTTASKVNLASKEAIDESVKQMTTLNKYAAEIIVNYPITACTDITGFGFLGHAYEMAKGSDKTLVFEGDFIPYIADAKEYAKEFLITTGGQQNRNFIGRDIDFGKNPLWLQEIMFDPQTSGGLLFSVKKEQVGALMKEFQEKNIDAYIIGSVEEKKEKYLIVR
>NZ_CP028102.1|WP_106991862.1|2384542_2385904_-|L-seryl-tRNA(Sec)-selenium-transferase
MNNLFRKLPKLDILMKNEKLDECREKLNYNTLYTLVKNEIDSFREKIKNREIEDFQVEDIIKNILDRAKFAGNNKLKKVINGSGVIIHTNLGRSVLNKKVVEKMGEVVSNYNNLEYDLETGKRGHRNSHVEELICKITGAEGALVVNNNAAAVIICLNEFARGKNSIVSRGELVEIGGSFRIPDIMELSGSKLKEVGTTNKTNISDYERAIDEETALILKVHRSNFKITGFTDEVGNRDISNLGKENGILTMEDLGSGVLVDFSKYGVVKEPTVQESISSGIDIITISGDKLLGGPQCGIILAKQEYIARLKKNQYLRAFRVDKLVLSALEGTLRYYLDEREAVREIPTLRMITEDKKEVLKRAEKLQKMLIEKNISTSIIETRAKIGGGSMPEETVPSYALVFTGDAVKLEKYFRTGDINIIGRVADDSFILDIKTIRDEDMEIIVEKAINM
>NZ_CP028102.1|WP_005886904.1|2394460_2395189_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MICSFTIYLKPLSFGEKIKKYKNYDYFIKELKIEFTDKELKKVVITNFLTKDNYIEDKKYSIKISALDSGILIKLFQFFFLKKIGEERIKIGETEFAILNIYNSNKYARQLNEESDIEISEDRLRVKIITPIFFKIGNRFIATNDINLILKNIEKKLKNSNILDIEDYLGISKYSSKIEMLEDYSREVKIEKEVVGKVGEIIYDISSLDDKEKREVIFLLKFAFFSGIGYMTEKGYGQIEMI
>NZ_CP028102.1|WP_005886902.1|2395191_2396343_-|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MIRKDIEKIECTIMPLTDIHIGSGIDLASYEYVIKDGVFYRIDLGEIFYNFPEDMRLKLTELMEENNIIKIRKYIKDNYKVEYGYSYSCEVADDVNELYEEKIGGARNSNDENSLTISEFIGNYRGKYIPGSSIKGSIRNAYIGDNFQGSYEIMRNKKINTAPFIIAKEKEYLARKIEAEALGLKELEPKFDPFKNLQVTDSEISKDMLKIVKVERVNLKKDKINVPMGNHEMMRGYLLSRDKKSLKFKINISELSFDRESEIKYRNLSQNKKGETIIEELNKELYVDSVLFPALREKSNKVLEEDLKFFKEAKNLIGIKACEEIKNYSATLKENEVLIKFGKGAGFNSTTLNLFNRNKKDVFTRVMAEGYPVGWAVLSYNEE
>NZ_CP028102.1|WP_005886900.1|2396339_2397284_-|hypothetical-protein
MYQTYLWNIKPLSSYMTPWQSDTIYGHFFWGVALLEGEDELKKILAEFEKNNPPFIVSDGFVDNRLPMISKRVIKNSEVERMAVEKNESIIDIATKIKRLKKVSTISLELFNKLRKKENDIVELVDEILDDNSKNRGIISIENTHNRIDRLSGSTGENAIFSLKENFVAENIFIYIKVRGDYPINKLEKILRFVEENGFGKKVSIGKGAFKTESFERFDGFEKISGNGFISLSNYIPKEEDYEYVENSLVLIKRGKVANLYGDEGNPFKKPFSCFRAGAIFRGKSSGIKGRVLTNLHRKKIIQVGIPFIVEVEL
>NZ_CP028102.1|WP_005886898.1|2397292_2397988_-|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MRLKSIKKIDGIIELLTGTRVGGSSDTIEIGGNDSPIVRNPLNNESYIPGSSLKGKMRMFMEWVEGKIDENGNVHSCTTPECPICRVFGRGAGDSEIAKSGPTRISVKDAYLTEESREILEKLREKVGFDTEWKYENNINRLTSKATPRNSERIPAGIKFEFSISYKVFDMNDNGKLDEELFEKVVLKGLKTLLIEGIGGGVSRGNGQIRFVKLDVDGESYIDKIENISIR
>NZ_CP028102.1|WP_005886896.1|2398001_2398469_-|type-III-A-CRISPR-associated-protein-Csm2
MFNNKGFDNRSRGNSRGYDNPEPVVFEFSKLGFLDNKGNLREELMTTEAENIAKSFERVSTAQLRAFFNEIKALKNRLENNDNNEHFERIYPFILMIKSKVQYRIAKDKKLEPLKNFLYAGIEEIQKQNKVGKGKEAFENFAIFFETIVGYAYKG
>NZ_CP028102.1|WP_005886894.1|2398461_2400855_-|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MVRLQDDKERVILGGLLHDIGKFIGRSEKYMSQCHIGKKHPHLSWWFIKFLEEKKVIEEDRVLEELVLKHHEGNFFSEDINVAGLEDKYLRRLAYIVARADNYSSAERNEDEMKMRPFTKVPLDSIFGNIDIGRGKDRESKKRYKLKEFLFGNIFPMEFEENSQEELNLLIEKFLKEVEKIETESFKVLYTTLLELIRKYCWSIPSDTQKEICDLSLYDHLKTTSAISLATYNYVKDLRGSIEKATDADIKNAKLKDYFLLIAGDISGIQNYIFNLESTEGAGKRIRFRSFFIKIFTNMIAYKIIEELDLEVGNIIISSSGKFYILAQNTQVTREKISKLKNEINRELYQKYYGEIFFNIEYLALTGDDLGLKFSKKYAEINDLLAEGKRLKFLKEVVELPVLDEEINEMKSVQQCKICGKRLVEKGNICEYCLKDFQLGELLPKLRKVAFYKGDSDVVGDIEILGVKCKLYKDEEIEGKPFLVQEYEEDIRGDYPWVREYYGGYTPIDSKGNSISFEEIAQLSSSKNLGILKGDVDNLGLIMAYGLKIDDVDGEEKKVKDITSISRVATVSRMFDSFFSYWLKEKIKYENESYIVYSGGDDFMIVGAWDKLIDTAKEIRESFRKFVRDNENITLTCGVVLTKAKAPLFYGVKTVQEAEEFGKNSGKNGIVLFDTYIPWDRFYEVDRVINFIDENMKSGLFSQSFVYRLLRYTEMARKYSESKNGKYLKYISDFTYDIGRNISKKLKNPSSDERIIFLSRYFGMESIQSREKQRFLSEYMKVVLNYVVRKNRGGSDV
>NZ_CP028102.1|WP_005886892.1|2400855_2401500_-|CRISPR-associated-endonuclease-Cas6
MKLVKIILKSNEKFENRDAEKLRGYFGRLFQENILFHNHKDDYNFNYDFSFIQYKVKNGEFLIVGIDKGGDILLEKIEDIREIVIEDRKIEITPEINISFPQLKVDDEKKYRYRFETIWLALNDKNFLRYKVGEFDLNKQLANNILEFFKMCGIRVEKRVEVVGEFQELKLRQKDTTILGFVGEFVTNAYLPDNISLGKRKSIGMGRIKRKGEV
>NZ_CP028102.1|WP_005886890.1|2401508_2403224_-|hypothetical-protein
MKKYEVANSLKSFLGKENNKILLKYSLEEKLSDEEKTELEKIYLENLQKQRKRIANKIKLENIEILISYVSYSYSENEKIYFENILEKNLRIFPNIKCFLLIYSKETEEIFKKTKVKFKNVDVNGILLEEVTSAHIQSNIQKYISKFKPNKNNSIIDITLGMKIITVYLYKLAVERGIFSINWQESQIPKYIYCEKQDEYIKDIGMRRYPFNTKLELMIEPEKENIKIYEYINKSLKKFEFSATESYYNQIGNSGMENFYRELSKIFSFQNMLSLDGENFYSQMENFFIKLSENRELSRENILKLKPFLSNLLSLILFESSEENIETRSFFWLDRFLTKFQIKSDELLENGFLSEYREKIYYFFILKYFESKKEEENSYYYEKFIKDLRKNILKELRVDEKEGKDFLRDGNIFELLDIDIEDIVENLNPSISLTESIKGDFYFENKVLYIEKYNLKIDCEKDERINFINNKGADILRELMKNYTVTFGGRELFERLAKYKNDESELARSNRFRKNLTVLKNKAKDFNNHLKEIGREEGIELGELILYQKIEEKESNYSHQFQINPKFYTLV
>NZ_CP028102.1|WP_005886888.1|2404090_2404375_-|CRISPR-associated-endonuclease-Cas2
MKVIIAYDIIENGVRNRIIEVLLEEGMMRIQKSVFFGEINEKKIKKLVKRVEGIIDKEIDSLYFFKLCEKDFSKVNYFGKNIEFHFFNKDFFII
>NZ_CP028102.1|WP_005886886.1|2404381_2404672_-|CRISPR-associated-endonuclease-Cas2
MKYIVSYDISVGKIRKEFSDFLKSEGFIRIQKSVFLGKINKKYMYKRFRDWIEKIDKIEDSIIVFPLCDLDFEESYFLGITFDIKDIEKFENMFIM

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Crispr_ID: NZ_CP028102_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028102_3

2403345-2403858

TypeIII

Consensus_repeat	Method
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	CRISPRCasFinder
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	CRT
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	PILER-CR

6 spacers

cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,cas2,cas1

The CRISPR arrays of NZ_CP028102_3

>merge|NZ_CP028102|3|2403345-2403858|CRISPRCasFinder,CRT,PILER-CR
TTGACTATCCTTATTGTTACTGGTCCTATCTTTTAACTTAAATAGCTTTATTATGCAATTAGGAATAGAATTGCATTTAGGAGTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAACTTATAAGGAAACTCGAGCCAGAGAGCCGTAACCCTTTAAATTAATAAAGTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAACAAAAAACAACTAAAATTCAAGGTGGAAAAACAAATAATTTAGGTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAACTTAAAAATATTAAAAATTGAATTAAGAGGTAAAAAAGTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAACTGTGGTAAGTGCTATGAGTGTAAAAAAGCTAGAAAATCAAAGTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAACTTAAAACGATAAGGGGGTATAATGAGAACTGAAATATTAGTTTGTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC

>NZ_CP028102|3|3|2403345-2403858|CRISPRCasFinder
TTGACTATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAATAGCTTTATTATGCAATTAGGAATAGAATTGCATTTAGGA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTATAAGGAAACTCGAGCCAGAGAGCCGTAACCCTTTAAATTAATAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	AAAAAACAACTAAAATTCAAGGTGGAAAAACAAATAATTTAG
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAAAATATTAAAAATTGAATTAAGAGGTAAAAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TGTGGTAAGTGCTATGAGTGTAAAAAAGCTAGAAAATCAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAAACGATAAGGGGGTATAATGAGAACTGAAATATTAGTTT
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC

>NZ_CP028102|3|2|2403345-2403858|CRT
TTGACTATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAATAGCTTTATTATGCAATTAGGAATAGAATTGCATTTAGGA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTATAAGGAAACTCGAGCCAGAGAGCCGTAACCCTTTAAATTAATAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	AAAAAACAACTAAAATTCAAGGTGGAAAAACAAATAATTTAG
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAAAATATTAAAAATTGAATTAAGAGGTAAAAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TGTGGTAAGTGCTATGAGTGTAAAAAAGCTAGAAAATCAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAAACGATAAGGGGGTATAATGAGAACTGAAATATTAGTTT
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC

>NZ_CP028102|3|2|2403427-2403858|PILER-CR
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTATAAGGAAACTCGAGCCAGAGAGCCGTAACCCTTTAAATTAATAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	AAAAAACAACTAAAATTCAAGGTGGAAAAACAAATAATTTAG
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAAAATATTAAAAATTGAATTAAGAGGTAAAAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TGTGGTAAGTGCTATGAGTGTAAAAAAGCTAGAAAATCAAA
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC	TTAAAACGATAAGGGGGTATAATGAGAACTGAAATATTAGTTT
GTTTCAATCCTTATTGTTACTGGTCCTATCTTTTAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028102.1\|WP_005886877.1\|2406932_2407772_-\|5'-nucleotidase,-lipoprotein-e(P4)-family	unknown	unknown	gnl\|CDD\|273674
NZ_CP028102.1\|WP_005886892.1\|2400855_2401500_-\|CRISPR-associated-endonuclease-Cas6	cas6	cls000004_cas6_CAS-I:CAS-III	gnl\|CDD\|379957
NZ_CP028102.1\|WP_005886875.1\|2408024_2409422_-\|YfcC-family-protein	unknown	unknown	gnl\|CDD\|224207
NZ_CP028102.1\|WP_005886869.1\|2412109_2412799_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP028102.1\|WP_005886880.1\|2405775_2406609_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005886883.1\|2404649_2405633_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187766
NZ_CP028102.1\|WP_005886888.1\|2404090_2404375_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP028102.1\|WP_005886886.1\|2404381_2404672_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP028102.1\|WP_040494122.1\|2392547_2392925_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP028102.1\|WP_005886898.1\|2397292_2397988_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NZ_CP028102.1\|WP_005886904.1\|2394460_2395189_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP028102.1\|WP_005886902.1\|2395191_2396343_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	mkCas0182_csm5gr7_CAS-III-A	gnl\|CDD\|224251
NZ_CP028102.1\|WP_005886865.1\|2414277_2415582_-\|TRAP-transporter-large-permease	unknown	unknown	gnl\|CDD\|224509
NZ_CP028102.1\|WP_005886894.1\|2398461_2400855_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NZ_CP028102.1\|WP_106991863.1\|2393039_2393855_-\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|319871
NZ_CP028102.1\|WP_005886890.1\|2401508_2403224_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028102.1\|WP_005886896.1\|2398001_2398469_-\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NZ_CP028102.1\|WP_005886900.1\|2396339_2397284_-\|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	gnl\|CDD\|187794
NZ_CP028102.1\|WP_005886871.1\|2411333_2412092_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP028102.1\|WP_005886873.1\|2409780_2410974_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349921

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP028102.1\|WP_005886898.1\|2397292_2397988_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	1.5e-62	205.9	0.7
NZ_CP028102.1\|WP_005886892.1\|2400855_2401500_-\|CRISPR-associated-endonuclease-Cas6	cas6	cls000004_cas6_CAS-I:CAS-III	4.2e-52	171.6	4.9
NZ_CP028102.1\|WP_005886904.1\|2394460_2395189_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	4.9e-11	38.1	18.3
NZ_CP028102.1\|WP_005886894.1\|2398461_2400855_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	4.7e-138	456.2	12.3
NZ_CP028102.1\|WP_005886883.1\|2404649_2405633_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	2.4e-58	192.4	6.7
NZ_CP028102.1\|WP_005886896.1\|2398001_2398469_-\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	pfam03750_csm2gr11_CAS-III-A	8.3e-16	53.2	3.1
NZ_CP028102.1\|WP_005886888.1\|2404090_2404375_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	5.1e-22	72.8	1.1
NZ_CP028102.1\|WP_005886886.1\|2404381_2404672_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	1.3e-17	58.6	1.4
NZ_CP028102.1\|WP_005886900.1\|2396339_2397284_-\|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	5.5e-58	191.4	0.0
NZ_CP028102.1\|WP_005886902.1\|2395191_2396343_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	mkCas0182_csm5gr7_CAS-III-A	5.3e-141	464.8	27.4

Protein	Function_ID	Function_description	E-value
NZ_CP028102.1\|WP_005886877.1\|2406932_2407772_-\|5'-nucleotidase,-lipoprotein-e(P4)-family	gnl\|CDD\|273674	TIGR01533, Lipoprotein_E, 5'-nucleotidase, lipoprotein e(P4) family. This model represents a set of bacterial lipoproteins belonging to a larger acid phosphatase family (pfam03767), which in turn belongs to the haloacid dehalogenase (HAD) superfamily of aspartate-dependent hydrolases. Members are found on the outer membrane of Gram-negative bacteria and the cytoplasmic membrane of Gram-positive bacteria. Most members have classic lipoprotein signal sequences. A critical role of this 5'-nucleotidase in Haemophilus influenzae is the degradation of external riboside in order to allow transport into the cell. An earlier suggested role in hemin transport is no longer current. This enzyme may also have other physiologically significant roles. [Transport and binding proteins, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides].	7.71768e-99
NZ_CP028102.1\|WP_005886892.1\|2400855_2401500_-\|CRISPR-associated-endonuclease-Cas6	gnl\|CDD\|379957	pfam17262, DUF5328, Family of unknown function (DUF5328). This family of unknown function can be found in Bacteria and Archaea. Some of the proteins in this family are annotated in UniProt as putative DNA repair proteins.	2.13833e-22
NZ_CP028102.1\|WP_005886875.1\|2408024_2409422_-\|YfcC-family-protein	gnl\|CDD\|224207	COG1288, COG1288, Predicted membrane protein [Function unknown].	1.82285e-125
NZ_CP028102.1\|WP_005886869.1\|2412109_2412799_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	6.13599e-41
NZ_CP028102.1\|WP_005886883.1\|2404649_2405633_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	7.63267e-58
NZ_CP028102.1\|WP_005886888.1\|2404090_2404375_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.07027e-17
NZ_CP028102.1\|WP_005886886.1\|2404381_2404672_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	5.66832e-12
NZ_CP028102.1\|WP_040494122.1\|2392547_2392925_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	2.32822e-30
NZ_CP028102.1\|WP_005886898.1\|2397292_2397988_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.01763e-70
NZ_CP028102.1\|WP_005886904.1\|2394460_2395189_-\|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	0.00102863
NZ_CP028102.1\|WP_005886902.1\|2395191_2396343_-\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|224251	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.73569e-10
NZ_CP028102.1\|WP_005886865.1\|2414277_2415582_-\|TRAP-transporter-large-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	2.62137e-116
NZ_CP028102.1\|WP_005886894.1\|2398461_2400855_-\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	9.37032e-133
NZ_CP028102.1\|WP_106991863.1\|2393039_2393855_-\|4Fe-4S-binding-protein	gnl\|CDD\|319871	cd10549, MtMvhB_like, Uncharacterized polyferredoxin-like protein. This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.	1.26909e-08
NZ_CP028102.1\|WP_005886896.1\|2398001_2398469_-\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	1.3923e-14
NZ_CP028102.1\|WP_005886900.1\|2396339_2397284_-\|hypothetical-protein	gnl\|CDD\|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.16745e-17
NZ_CP028102.1\|WP_005886871.1\|2411333_2412092_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.0176e-51
NZ_CP028102.1\|WP_005886873.1\|2409780_2410974_-\|M20-family-metallopeptidase	gnl\|CDD\|349921	cd05672, M20_ACY1L2-like, M20 Peptidase aminoacylase 1-like protein 2-like, amidohydrolase subfamily. Peptidase M20 family, aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase)-like subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. This subfamily includes Staphylococcus aureus antibiotic resistance factor HmrA that has been shown to participate in methicillin resistance mechanisms in vivo in the presence of beta-lactams. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	3.92912e-151

>NZ_CP028102.1|WP_005886890.1|2401508_2403224_-|hypothetical-protein
MKKYEVANSLKSFLGKENNKILLKYSLEEKLSDEEKTELEKIYLENLQKQRKRIANKIKLENIEILISYVSYSYSENEKIYFENILEKNLRIFPNIKCFLLIYSKETEEIFKKTKVKFKNVDVNGILLEEVTSAHIQSNIQKYISKFKPNKNNSIIDITLGMKIITVYLYKLAVERGIFSINWQESQIPKYIYCEKQDEYIKDIGMRRYPFNTKLELMIEPEKENIKIYEYINKSLKKFEFSATESYYNQIGNSGMENFYRELSKIFSFQNMLSLDGENFYSQMENFFIKLSENRELSRENILKLKPFLSNLLSLILFESSEENIETRSFFWLDRFLTKFQIKSDELLENGFLSEYREKIYYFFILKYFESKKEEENSYYYEKFIKDLRKNILKELRVDEKEGKDFLRDGNIFELLDIDIEDIVENLNPSISLTESIKGDFYFENKVLYIEKYNLKIDCEKDERINFINNKGADILRELMKNYTVTFGGRELFERLAKYKNDESELARSNRFRKNLTVLKNKAKDFNNHLKEIGREEGIELGELILYQKIEEKESNYSHQFQINPKFYTLV
>NZ_CP028102.1|WP_005886892.1|2400855_2401500_-|CRISPR-associated-endonuclease-Cas6
MKLVKIILKSNEKFENRDAEKLRGYFGRLFQENILFHNHKDDYNFNYDFSFIQYKVKNGEFLIVGIDKGGDILLEKIEDIREIVIEDRKIEITPEINISFPQLKVDDEKKYRYRFETIWLALNDKNFLRYKVGEFDLNKQLANNILEFFKMCGIRVEKRVEVVGEFQELKLRQKDTTILGFVGEFVTNAYLPDNISLGKRKSIGMGRIKRKGEV
>NZ_CP028102.1|WP_005886894.1|2398461_2400855_-|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MVRLQDDKERVILGGLLHDIGKFIGRSEKYMSQCHIGKKHPHLSWWFIKFLEEKKVIEEDRVLEELVLKHHEGNFFSEDINVAGLEDKYLRRLAYIVARADNYSSAERNEDEMKMRPFTKVPLDSIFGNIDIGRGKDRESKKRYKLKEFLFGNIFPMEFEENSQEELNLLIEKFLKEVEKIETESFKVLYTTLLELIRKYCWSIPSDTQKEICDLSLYDHLKTTSAISLATYNYVKDLRGSIEKATDADIKNAKLKDYFLLIAGDISGIQNYIFNLESTEGAGKRIRFRSFFIKIFTNMIAYKIIEELDLEVGNIIISSSGKFYILAQNTQVTREKISKLKNEINRELYQKYYGEIFFNIEYLALTGDDLGLKFSKKYAEINDLLAEGKRLKFLKEVVELPVLDEEINEMKSVQQCKICGKRLVEKGNICEYCLKDFQLGELLPKLRKVAFYKGDSDVVGDIEILGVKCKLYKDEEIEGKPFLVQEYEEDIRGDYPWVREYYGGYTPIDSKGNSISFEEIAQLSSSKNLGILKGDVDNLGLIMAYGLKIDDVDGEEKKVKDITSISRVATVSRMFDSFFSYWLKEKIKYENESYIVYSGGDDFMIVGAWDKLIDTAKEIRESFRKFVRDNENITLTCGVVLTKAKAPLFYGVKTVQEAEEFGKNSGKNGIVLFDTYIPWDRFYEVDRVINFIDENMKSGLFSQSFVYRLLRYTEMARKYSESKNGKYLKYISDFTYDIGRNISKKLKNPSSDERIIFLSRYFGMESIQSREKQRFLSEYMKVVLNYVVRKNRGGSDV
>NZ_CP028102.1|WP_005886896.1|2398001_2398469_-|type-III-A-CRISPR-associated-protein-Csm2
MFNNKGFDNRSRGNSRGYDNPEPVVFEFSKLGFLDNKGNLREELMTTEAENIAKSFERVSTAQLRAFFNEIKALKNRLENNDNNEHFERIYPFILMIKSKVQYRIAKDKKLEPLKNFLYAGIEEIQKQNKVGKGKEAFENFAIFFETIVGYAYKG
>NZ_CP028102.1|WP_005886898.1|2397292_2397988_-|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MRLKSIKKIDGIIELLTGTRVGGSSDTIEIGGNDSPIVRNPLNNESYIPGSSLKGKMRMFMEWVEGKIDENGNVHSCTTPECPICRVFGRGAGDSEIAKSGPTRISVKDAYLTEESREILEKLREKVGFDTEWKYENNINRLTSKATPRNSERIPAGIKFEFSISYKVFDMNDNGKLDEELFEKVVLKGLKTLLIEGIGGGVSRGNGQIRFVKLDVDGESYIDKIENISIR
>NZ_CP028102.1|WP_005886900.1|2396339_2397284_-|hypothetical-protein
MYQTYLWNIKPLSSYMTPWQSDTIYGHFFWGVALLEGEDELKKILAEFEKNNPPFIVSDGFVDNRLPMISKRVIKNSEVERMAVEKNESIIDIATKIKRLKKVSTISLELFNKLRKKENDIVELVDEILDDNSKNRGIISIENTHNRIDRLSGSTGENAIFSLKENFVAENIFIYIKVRGDYPINKLEKILRFVEENGFGKKVSIGKGAFKTESFERFDGFEKISGNGFISLSNYIPKEEDYEYVENSLVLIKRGKVANLYGDEGNPFKKPFSCFRAGAIFRGKSSGIKGRVLTNLHRKKIIQVGIPFIVEVEL
>NZ_CP028102.1|WP_005886902.1|2395191_2396343_-|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MIRKDIEKIECTIMPLTDIHIGSGIDLASYEYVIKDGVFYRIDLGEIFYNFPEDMRLKLTELMEENNIIKIRKYIKDNYKVEYGYSYSCEVADDVNELYEEKIGGARNSNDENSLTISEFIGNYRGKYIPGSSIKGSIRNAYIGDNFQGSYEIMRNKKINTAPFIIAKEKEYLARKIEAEALGLKELEPKFDPFKNLQVTDSEISKDMLKIVKVERVNLKKDKINVPMGNHEMMRGYLLSRDKKSLKFKINISELSFDRESEIKYRNLSQNKKGETIIEELNKELYVDSVLFPALREKSNKVLEEDLKFFKEAKNLIGIKACEEIKNYSATLKENEVLIKFGKGAGFNSTTLNLFNRNKKDVFTRVMAEGYPVGWAVLSYNEE
>NZ_CP028102.1|WP_005886904.1|2394460_2395189_-|CRISPR-system-precrRNA-processing-endoribonuclease-RAMP-protein-Cas6
MICSFTIYLKPLSFGEKIKKYKNYDYFIKELKIEFTDKELKKVVITNFLTKDNYIEDKKYSIKISALDSGILIKLFQFFFLKKIGEERIKIGETEFAILNIYNSNKYARQLNEESDIEISEDRLRVKIITPIFFKIGNRFIATNDINLILKNIEKKLKNSNILDIEDYLGISKYSSKIEMLEDYSREVKIEKEVVGKVGEIIYDISSLDDKEKREVIFLLKFAFFSGIGYMTEKGYGQIEMI
>NZ_CP028102.1|WP_106991863.1|2393039_2393855_-|4Fe-4S-binding-protein
MKKVWGMYFSGTGTTEKVVKRIANTLGEKLGVERENIDFTSKSAREKEYIFSKEDIVVFGVPVIAGRVPNLLLKFLDTIRGEGALAVPIVLFGNRNYDDALIELRDILLKDGFFVVGAGAFVGEHSFSRELGKGRPDREDLEIADILAEKVIENMENKKYLSEKLYVKGESPYRWYYQPRDSKGNPIDIRKVKPKTNMELCNNCGLCVELCPLGSIEKERVDVVSGICMKCCACIKKCPQGAKYFDDKNFIYHKEELELEYSRRAKVEIFY
>NZ_CP028102.1|WP_040494122.1|2392547_2392925_-|rhodanese-like-domain-containing-protein
MKRVIIGVLIMINTITNSYGKELAYQIISQEKAKEMMEENNNYIILDVRTDWEYKMGHIAGAINIPNEEIGHQEIEELPDKNQPILVYCRSGHRSKQASSKLAVLGYKNIYEFGGVITWEYGLVE
>NZ_CP028102.1|WP_005886888.1|2404090_2404375_-|CRISPR-associated-endonuclease-Cas2
MKVIIAYDIIENGVRNRIIEVLLEEGMMRIQKSVFFGEINEKKIKKLVKRVEGIIDKEIDSLYFFKLCEKDFSKVNYFGKNIEFHFFNKDFFII
>NZ_CP028102.1|WP_005886886.1|2404381_2404672_-|CRISPR-associated-endonuclease-Cas2
MKYIVSYDISVGKIRKEFSDFLKSEGFIRIQKSVFLGKINKKYMYKRFRDWIEKIDKIEDSIIVFPLCDLDFEESYFLGITFDIKDIEKFENMFIM
>NZ_CP028102.1|WP_005886883.1|2404649_2405633_-|CRISPR-associated-endonuclease-Cas1
MDLFVQKNGSKIYREKEYFVVERKEEGKEYFSYNLIDNIIIQEGNQLTSDFLLEIIEKDIPLYLGDKYGNIRGKFTPITYNTNSNIRERQYQLWIREYGKELGKSWIMEKIENQKKHIQKIYSRRGVLDKFLEIERKFDENITKIKNITWNDKDFENRVMGYEGRSSILYYEEIKKFLPENWSFTKRETQGAKEPYNIVLNYAFGILYFKLERYLTLAGLDIQLGIIHSNNNKSNSLIFDFIEPFRILAWECAFSLFSKKELNKNYFNLNEGKIELEGKRVIAKDLYNRLKNIVEYNGKKMSYEEKIEKRAKELVKELMKNEIYSKL
>NZ_CP028102.1|WP_005886880.1|2405775_2406609_+|hypothetical-protein
MEIFLELNYYYNKYPHISLVKNKMEIVKKFKSLENSLLLSKNILNLDEIIFKQLNFTVSFSNYRYIYLLSQINSIKNIQENILQFIFKFFDNFIYSSTYYPHIHYLIKILAKFFTNKIEEKILTFKNKPIFDTYLKEFIILMGNIGGKSSLSILFSIIKKDFTQREYCFLSIGKITSYQRYPVIKRTFLKDYINFICKILHRDISINQSSYLYYSLIEIFLLPNGIDGKLQNKLSEVLYLHKDKNLYKNIALKVINNSLLDENEKNLIKSLYLIIPL
>NZ_CP028102.1|WP_005886877.1|2406932_2407772_-|5'-nucleotidase,-lipoprotein-e(P4)-family
MKNKKLLSLLAISITILTMTGCSNLYEKKDEKVVLTYDELAARENMMGTNWYQTSGEAKALYLQGYNVATQRLKEYLKVPHSKPYSIVLDLDETVVDNSPYQAENILRGRGYDTESWDEWVQMKKAKAVPGAKEFLQFADKNGVKIYYISDRAESQLEATIENLKAEGIPVQGEDSVLLKNKEDKSGKVNRREYVKKHTQLIMLFGDNLSDFDVFSSKSIDERDNKVEELAKEFGDRFIIFPNPMYGAFESAIYGGKFPQAKEKVEIRESTLKSYKSLN
>NZ_CP028102.1|WP_005886875.1|2408024_2409422_-|YfcC-family-protein
MEQRKRFSMPHTYVLIGMILVILTGLTYLVPSGSYQRAVDPVLNRTMVVANSFEYVAQTPVSIFRMFKAIIDGLVSTSDIIFFIFFAYGYINMLISTGAFYGGLGTVIKRFNGRETLIFPIFMVIFGICGSTFGLYEETYGLLPAFMGISVALGYDALVGGAAVIVGTATGFAAATLNPFTIGIAQGIAEVPIGSGIGLRTIAFIVFQATAIIYVMMYARKVKLNPEKSIVKDVKFNFSNGMTRDELEGLPFTNKHKLIMGLFLITIGILVYGTTHYGWYLNELSTLFFIMMLITGLIGGYNFSQISQHFITSTSDVLFGAFAVGVARALTIVMEDGQIIDTIINSMAATLSTLPKSIAAVGMVVVQNMINFFIPSGSGQAATSMPIMAPLADAIGLTRQTAVLAFQFGDGFSNLFWPTSAATMCGLMSLPINKWYKFITPLFLIMFGLQVIFIIIAVAINYGPF
>NZ_CP028102.1|WP_005886873.1|2409780_2410974_-|M20-family-metallopeptidase
MELKKELYKIEDELKKEIEGVSDYIFKNPELGNEEYKAVEFLIKELEKNNFRVEKNYCGMETAFRAEIGEGSPKIAFLAEYDALPGYGVEKKPGHACGHNWIAASTYGTALVLSKMLDKFNGTIVFIGTPAEETVGGKVPMVESGTFNDVDVVFQMHLESQNNIACKTLAIDCIKFQFKGRASHAAAHPEDGINALDAINLMYAGIGCLRQHITSDARIHGIITHGGDAPNTVPDLTEARFHIRANNREYLNNLTEKVINIAKGASMMTGTEMSWEKFENSFDNLVNLKSLQELMKKNLLEVGIKNIQDEGKGATGSSDIGNVSQVCPTMYTEVALEIEEVCHVHDEAYLKYVNSKEAYDKLHRGVKAMGGSALEILTNKELLEKIKKEWRELKNIK
>NZ_CP028102.1|WP_005886871.1|2411333_2412092_+|IclR-family-transcriptional-regulator
MEEKSKVPAIDKADKIFNYLYYKYSATQSSISKDLNLPKATVNRLLEVLTNLKYLNYQDKEYTLGEKFYFFSNRYEKYTLIKNITHPYLEELSLKFKETFKLSVLDNDKIRSIATVESSDLIKVSVAENAIFPLHAGAASKLLICQLSESKLNKLLTKTLPKYTDNTITDREKLKEELLKINIQKVSYDNMEHSKNIKAVAVPILDKKNRIIAAISCPCFPDDLTDEKSKFLVKEMQKTCEEISKRLEYFIN
>NZ_CP028102.1|WP_005886869.1|2412109_2412799_+|GntR-family-transcriptional-regulator
MLLENTTKKKNENNREFIYRVIKENIMTLNLKPGECISEVELGNQLNVSRTPVREAIVRLSEEKLIDVFPQKGSFVSKIDLNLVDEAVFLRALCEKEILKLACSDKNSKELIRELEKNLAYQKIIIDFEEDLHKFFDLDNELHALIFYYYNKKNVWKSVKRLATHYDRLRLIDALEKFSATKTYEQHHDIIDIIKNKTTENIDNLISEHLSKFKHVINNYLDKYPEYFK
>NZ_CP028102.1|WP_005886865.1|2414277_2415582_-|TRAP-transporter-large-permease
MVLTTALIMFIVLVITLLLGFPIAISIGLSSILAILPSLAFDNTLVTGAQRIFSGISNFTLIAIPFFILAGNIMNQGGIAKKLVSFAQSLTGRIPGSLMQTNILANMMFGAISGSATAACAAMGGILLPMEEEQGYDKKLGATANIASAPTGLLIPPSNSLIVYSLVSGGTSVAALFMAGYLPGILWGIGCMALTLYLCKAKGMKGTNNFKLKVVLVTFIDALPSLALIIIVIGGIIKGIFTPTEGSVVAVVYTLILSMLFYRTITIKGLIEIFAESAKMTGIIVFLIGVSTIMSWVMAFTGVPQAISSLILGLTNNKFLILLLMNLLLLFIGTFMDVTPAILIFTPIFLPIVQSFGMSAVQFGIIIVFNLCIGNITPPVGNTLFVGVKVGNLKIEDVMGQLIKYYVVIIIVLMLVTYIPAISMYLPTIGGFVK

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1294640 : 1316146

Clostridium_phage(36.36%)

portal,capsid,plate,head,tail,holin,protease,terminase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005884185.1\|1294640_1295120_-\|holin	phage holin family protein	M9Q253	Clostridium_phage	1.8e-13	36.3
WP_005884188.1\|1295130_1295376_-	hypothetical protein	NA	NA	NA	NA
WP_005884190.1\|1295397_1295811_-	M15 family metallopeptidase	A0A0E3Y6B0	Fusobacterium_phage	3.1e-30	48.1
WP_005884192.1\|1295907_1296480_-	hypothetical protein	NA	NA	NA	NA
WP_005884195.1\|1296632_1296950_-	hypothetical protein	NA	NA	NA	NA
WP_005884197.1\|1296968_1297901_-	hypothetical protein	NA	NA	NA	NA
WP_005884199.1\|1298440_1299187_-	hypothetical protein	A0A0F6R6B6	Escherichia_coli_O157_typing_phage	7.1e-09	29.3
WP_005884201.1\|1299199_1299988_-	hypothetical protein	NA	NA	NA	NA
WP_005884203.1\|1300000_1300549_-	hypothetical protein	NA	NA	NA	NA
WP_005884205.1\|1300553_1300814_-	hypothetical protein	NA	NA	NA	NA
WP_005884207.1\|1300813_1301356_-	DUF2313 domain-containing protein	NA	NA	NA	NA
WP_005884209.1\|1301345_1302440_-\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	7.6e-60	39.8
WP_005884211.1\|1302432_1302885_-	DUF2634 domain-containing protein	NA	NA	NA	NA
WP_005884213.1\|1302896_1303319_-	DUF2577 family protein	NA	NA	NA	NA
WP_005884215.1\|1303308_1304262_-	hypothetical protein	NA	NA	NA	NA
WP_005884217.1\|1304266_1304665_-	hypothetical protein	NA	NA	NA	NA
WP_005884219.1\|1304666_1304981_-	hypothetical protein	NA	NA	NA	NA
WP_005884221.1\|1304990_1307204_-	hypothetical protein	NA	NA	NA	NA
WP_005884223.1\|1307397_1307826_-	hypothetical protein	NA	NA	NA	NA
WP_005884225.1\|1307866_1308274_-	hypothetical protein	NA	NA	NA	NA
WP_005884228.1\|1308284_1309376_-	hypothetical protein	A0A090D804	Clostridium_phage	7.9e-25	26.0
WP_005884230.1\|1309362_1309812_-	hypothetical protein	NA	NA	NA	NA
WP_005884232.1\|1309820_1310225_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_005884234.1\|1310211_1310556_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_005884236.1\|1310548_1310833_-\|head,tail	phage gp6-like head-tail connector protein	A0A2H4J6E5	uncultured_Caudovirales_phage	2.4e-05	40.7
WP_005884238.1\|1310847_1311990_-\|capsid	phage major capsid protein	Q9ZXF6	Bacillus_phage	5.5e-69	39.6
WP_005884240.1\|1311994_1312741_-\|protease	Clp protease ClpP	A0A0A8WFM9	Clostridium_phage	1.6e-45	45.7
WP_040493720.1\|1312712_1313981_-\|portal	phage portal protein	A6M949	Geobacillus_virus	8.4e-87	45.0
WP_005884244.1\|1313993_1315691_-\|terminase	terminase large subunit	A6M948	Geobacillus_virus	3.9e-119	40.6
WP_005884246.1\|1315687_1316146_-\|terminase	P27 family phage terminase small subunit	M1PKP2	Streptococcus_phage	1.8e-07	31.0

DBSCAN-SWA_2

1395220 : 1471102

Fusobacterium_phage(75.86%)

portal,capsid,plate,integrase,tail,protease,transposase,holin,terminase

attL 1422302:1422318|attR 1472627:1472643

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_187106602.1\|1395220_1395691_-\|transposase	transposase	NA	NA	NA	NA
WP_106991803.1\|1395976_1396324_-\|transposase	transposase zinc-binding domain-containing protein	NA	NA	NA	NA
WP_005884392.1\|1396529_1396883_+	hypothetical protein	NA	NA	NA	NA
WP_005884393.1\|1396898_1398080_+	CoA transferase	NA	NA	NA	NA
WP_005884395.1\|1398104_1398647_+	manganese efflux pump	NA	NA	NA	NA
WP_005884397.1\|1398717_1399371_-	murein L,D-transpeptidase catalytic domain family protein	NA	NA	NA	NA
WP_005884399.1\|1399521_1400868_+	AAA family ATPase	NA	NA	NA	NA
WP_005884401.1\|1401081_1402152_-	M42 family metallopeptidase	NA	NA	NA	NA
WP_005884403.1\|1402167_1403697_-	DNA-binding protein	NA	NA	NA	NA
WP_106991879.1\|1403826_1404675_-	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_040493730.1\|1404717_1405371_-	DUF45 domain-containing protein	NA	NA	NA	NA
WP_005884409.1\|1405503_1407306_+	elongation factor 4	E4ZFJ7	Streptococcus_phage	3.6e-22	24.1
WP_005884411.1\|1407324_1408335_+	glycosyltransferase family 9 protein	NA	NA	NA	NA
WP_005884413.1\|1408399_1409131_-	fimbria/pilus periplasmic chaperone	NA	NA	NA	NA
WP_005884415.1\|1409142_1409640_-	hypothetical protein	NA	NA	NA	NA
WP_005884417.1\|1409653_1410535_-	toxin-antitoxin system YwqK family antitoxin	NA	NA	NA	NA
WP_005884419.1\|1410531_1413072_-	hypothetical protein	NA	NA	NA	NA
WP_005884420.1\|1413064_1413907_-	DUF4402 domain-containing protein	NA	NA	NA	NA
WP_005884422.1\|1413919_1415275_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_005884424.1\|1417622_1419818_+	alpha-galactosidase	NA	NA	NA	NA
WP_005884426.1\|1419838_1421197_+	melibiose:sodium transporter MelB	NA	NA	NA	NA
WP_005884428.1\|1421211_1423158_+	beta-galactosidase	NA	NA	NA	NA
1422302:1422318	attL	NA	NA	NA	NA
WP_005884430.1\|1423264_1424281_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_040493734.1\|1424570_1425905_-	magnesium transporter	NA	NA	NA	NA
WP_005884434.1\|1426060_1427362_+	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	NA	NA	NA	NA
WP_005884436.1\|1427373_1428030_+	O-methyltransferase	NA	NA	NA	NA
WP_005884438.1\|1428058_1428622_-	hypothetical protein	NA	NA	NA	NA
WP_005884440.1\|1428630_1430064_-	recombinase family protein	E5DV73	Deep-sea_thermophilic_phage	2.4e-13	23.3
WP_005884444.1\|1430215_1430755_-	DUF4241 domain-containing protein	NA	NA	NA	NA
WP_005884447.1\|1430877_1431162_-	hypothetical protein	S4SGC9	Salmonella_phage	8.3e-19	48.9
WP_005884449.1\|1431162_1431741_-	hypothetical protein	NA	NA	NA	NA
WP_005884451.1\|1431740_1431959_-	hypothetical protein	NA	NA	NA	NA
WP_005884453.1\|1431961_1432174_-	hypothetical protein	NA	NA	NA	NA
WP_005884454.1\|1432170_1432317_-	hypothetical protein	NA	NA	NA	NA
WP_005884456.1\|1432328_1432766_-	hypothetical protein	NA	NA	NA	NA
WP_005884458.1\|1432786_1433296_-	DUF2786 domain-containing protein	NA	NA	NA	NA
WP_005884459.1\|1433392_1434373_-	hypothetical protein	NA	NA	NA	NA
WP_005884462.1\|1434372_1435083_-	ParA family protein	A0A0E3Y677	Fusobacterium_phage	3.1e-46	44.7
WP_005884464.1\|1435069_1435402_-	hypothetical protein	NA	NA	NA	NA
WP_005884465.1\|1435388_1435616_-	hypothetical protein	NA	NA	NA	NA
WP_005884468.1\|1435616_1436543_-	helix-turn-helix domain-containing protein	A0A1V0E018	Clostridioides_phage	8.2e-15	43.2
WP_005884470.1\|1436555_1436783_-	hypothetical protein	NA	NA	NA	NA
WP_005884474.1\|1437053_1437296_-	hypothetical protein	NA	NA	NA	NA
WP_005884476.1\|1437550_1437778_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_005884478.1\|1437890_1439063_+	hypothetical protein	NA	NA	NA	NA
WP_005884480.1\|1439296_1439659_-	hypothetical protein	NA	NA	NA	NA
WP_005884483.1\|1439690_1439936_-	hypothetical protein	NA	NA	NA	NA
WP_005884485.1\|1440504_1441098_+	hypothetical protein	NA	NA	NA	NA
WP_005884487.1\|1441234_1441414_+	hypothetical protein	NA	NA	NA	NA
WP_005884489.1\|1441451_1441685_+	hypothetical protein	NA	NA	NA	NA
WP_005884491.1\|1441903_1442983_+	hypothetical protein	A0A0E3U246	Fusobacterium_phage	8.5e-72	43.5
WP_005884493.1\|1443159_1444479_+	DNA modification methylase	A0A0E3Y5D8	Fusobacterium_phage	1.9e-137	56.7
WP_005884495.1\|1444471_1445221_+	helix-turn-helix domain-containing protein	A0A0E3Y615	Fusobacterium_phage	1.9e-33	42.9
WP_005884498.1\|1445366_1445831_+	hypothetical protein	A0A0E3Y4U4	Fusobacterium_phage	7.5e-33	53.3
WP_005884500.1\|1445811_1447590_+\|terminase	phage terminase large subunit family protein	A0A0E3U2N4	Fusobacterium_phage	4.9e-242	68.7
WP_005884503.1\|1447586_1447805_+	hypothetical protein	A0A0E3U247	Fusobacterium_phage	7.8e-17	54.2
WP_005884505.1\|1447815_1449315_+\|portal	phage portal protein	A0A0E3Y693	Fusobacterium_phage	1.4e-176	65.8
WP_005884508.1\|1449307_1450393_+\|protease	Clp protease ClpP	A0A0E3Y6E9	Fusobacterium_phage	5.4e-74	43.8
WP_005884510.1\|1450403_1450736_+	hypothetical protein	NA	NA	NA	NA
WP_005884512.1\|1450748_1451774_+\|capsid	major capsid protein	A0A0E3U2N5	Fusobacterium_phage	3.5e-99	55.6
WP_005884514.1\|1451804_1452047_+	hypothetical protein	NA	NA	NA	NA
WP_005884516.1\|1452012_1452366_+	hypothetical protein	A0A0E3Y618	Fusobacterium_phage	4.5e-14	37.3
WP_005884518.1\|1452367_1452940_+\|tail	phage tail protein	A0A0E3Y4U7	Fusobacterium_phage	1.5e-22	36.5
WP_005884520.1\|1452936_1453440_+	hypothetical protein	NA	NA	NA	NA
WP_005884522.1\|1453429_1453714_+	hypothetical protein	NA	NA	NA	NA
WP_005884524.1\|1453713_1455132_+\|tail	phage tail sheath family protein	A0A0E3U251	Fusobacterium_phage	3.2e-151	54.7
WP_005884526.1\|1455156_1455675_+\|tail	phage major tail tube protein	A0A0E3Y6F4	Fusobacterium_phage	2.3e-43	52.6
WP_005884528.1\|1455684_1456068_+	hypothetical protein	A0A0E3Y5E7	Fusobacterium_phage	6.4e-14	43.8
WP_005884530.1\|1456192_1456522_+	hypothetical protein	NA	NA	NA	NA
WP_005884532.1\|1456584_1459620_+\|tail	phage tail tape measure protein	A0A0E3U2N9	Fusobacterium_phage	3.6e-128	42.0
WP_005884534.1\|1459609_1459819_+\|tail	tail protein X	NA	NA	NA	NA
WP_005884536.1\|1459815_1460886_+	hypothetical protein	A0A0E3U253	Fusobacterium_phage	8.4e-88	45.4
WP_005884538.1\|1460878_1461400_+\|plate	phage baseplate assembly protein V	NA	NA	NA	NA
WP_005884540.1\|1461415_1461802_+\|tail	phage tail protein	A0A067ZI88	Vibrio_phage	2.2e-14	34.4
WP_005884542.1\|1461801_1462119_+	hypothetical protein	A0A0E3Y6F8	Fusobacterium_phage	3.3e-16	49.1
WP_005884544.1\|1462111_1463209_+\|plate	baseplate J/gp47 family protein	A0A0E3U2P1	Fusobacterium_phage	1.4e-114	58.0
WP_005884546.1\|1463201_1463777_+\|tail	phage tail protein I	A0A0E3U255	Fusobacterium_phage	1.2e-37	48.8
WP_106991823.1\|1463837_1466021_+	hypothetical protein	A0A0E3Y5F3	Fusobacterium_phage	9.9e-35	45.2
WP_081462360.1\|1466616_1466868_-	hypothetical protein	NA	NA	NA	NA
WP_005884553.1\|1467237_1467432_+	hypothetical protein	NA	NA	NA	NA
WP_040493610.1\|1467428_1467653_-	hypothetical protein	NA	NA	NA	NA
WP_005884554.1\|1468003_1468963_+\|integrase	tyrosine-type recombinase/integrase	A0A0E3U2P3	Fusobacterium_phage	7.3e-75	45.9
WP_005884558.1\|1469211_1469745_+	hypothetical protein	NA	NA	NA	NA
WP_005884560.1\|1469758_1469929_+	hypothetical protein	NA	NA	NA	NA
WP_005884562.1\|1469918_1470341_+	hypothetical protein	A0A0R6PID9	Moraxella_phage	4.4e-16	39.6
WP_005884564.1\|1470364_1470619_+	hypothetical protein	NA	NA	NA	NA
WP_005884566.1\|1470634_1471102_+\|holin	phage holin family protein	M9Q253	Clostridium_phage	6.0e-14	37.9
1472627:1472643	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1920044 : 1924745

uncultured_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_005885472.1\|1920044_1921634_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.5e-157	54.0
WP_005885471.1\|1921879_1922308_+	6-carboxytetrahydropterin synthase	J9PV91	Bacillus_phage	5.3e-09	31.9
WP_005885470.1\|1922307_1922976_+	putative 7-carboxy-7-deazaguanine synthase QueE	S4TZT1	uncultured_phage	3.1e-40	45.5
WP_005885469.1\|1922975_1923551_+	GTP cyclohydrolase I FolE	S4U0J3	uncultured_phage	1.0e-47	52.1
WP_005885468.1\|1923563_1924262_+	7-cyano-7-deazaguanine synthase QueC	A0A1U9WRB5	Streptococcus_virus	2.2e-60	51.6
WP_005885467.1\|1924262_1924745_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.8e-51	72.9

DBSCAN-SWA_4

1968316 : 2006606

Clostridium_phage(26.67%)

head,integrase,tail,holin,terminase

attL 1967454:1967470|attR 2011739:2011755

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1967454:1967470	attL	NA	NA	NA	NA
WP_005885381.1\|1968316_1968979_+	GIY-YIG nuclease family protein	A6M984	Geobacillus_virus	6.1e-20	31.7
WP_005885379.1\|1968978_1969974_+	hypothetical protein	M9Q2G6	Clostridium_phage	1.8e-20	44.7
WP_005885377.1\|1969984_1970260_+	hypothetical protein	NA	NA	NA	NA
WP_005885375.1\|1970260_1970512_+	hypothetical protein	NA	NA	NA	NA
WP_106991843.1\|1970640_1971039_+	hypothetical protein	NA	NA	NA	NA
WP_050795444.1\|1971077_1971779_+	site-specific DNA-methyltransferase	X2KMD0	Enterococcus_phage	1.1e-56	46.8
WP_005885365.1\|1971902_1972256_+	VRR-NUC domain-containing protein	NA	NA	NA	NA
WP_040493862.1\|1972280_1972580_+	hypothetical protein	NA	NA	NA	NA
WP_005885363.1\|1972576_1972792_+	hypothetical protein	NA	NA	NA	NA
WP_005885362.1\|1973245_1973425_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A0A8WHQ4	Clostridium_phage	2.1e-07	47.2
WP_005885360.1\|1973564_1974113_+	ParB N-terminal domain-containing protein	A0A0E3U266	Fusobacterium_phage	1.0e-41	56.7
WP_005885357.1\|1974105_1974903_+	hypothetical protein	A0A142IE79	Pseudomonas_phage	4.0e-18	31.5
WP_005885356.1\|1974918_1975575_+	DUF1804 family protein	NA	NA	NA	NA
WP_005885353.1\|1975574_1976915_+\|terminase	PBSX family phage terminase large subunit	A0A0E3Y6C0	Fusobacterium_phage	1.8e-63	36.8
WP_050795440.1\|1976895_1979076_+\|head	phage head morphogenesis protein	U5PW71	Bacillus_virus	7.4e-06	29.6
WP_005885349.1\|1979082_1979631_+	phage virion morphogenesis protein	NA	NA	NA	NA
WP_005885347.1\|1979643_1979808_+	hypothetical protein	NA	NA	NA	NA
WP_005885346.1\|1979791_1980769_+	hypothetical protein	NA	NA	NA	NA
WP_005885344.1\|1980782_1981151_+	hypothetical protein	NA	NA	NA	NA
WP_005885343.1\|1981154_1982138_+	hypothetical protein	NA	NA	NA	NA
WP_005885342.1\|1982183_1982579_+	hypothetical protein	NA	NA	NA	NA
WP_005885341.1\|1982571_1982997_+	hypothetical protein	NA	NA	NA	NA
WP_005885340.1\|1983009_1983525_+	hypothetical protein	NA	NA	NA	NA
WP_005885339.1\|1983591_1984218_+	hypothetical protein	NA	NA	NA	NA
WP_005885338.1\|1984214_1986902_+\|tail	phage tail tape measure protein	A0A0U4IIN6	Exiguobacterium_phage	3.0e-33	34.4
WP_005885336.1\|1986958_1987369_+	hypothetical protein	NA	NA	NA	NA
WP_005885335.1\|1987365_1988943_+	hypothetical protein	NA	NA	NA	NA
WP_005885332.1\|1988939_1989857_+	hypothetical protein	NA	NA	NA	NA
WP_106991844.1\|1989866_1990907_+	hypothetical protein	NA	NA	NA	NA
WP_106991845.1\|1990946_1991306_+	hypothetical protein	NA	NA	NA	NA
WP_005885328.1\|1991348_1991636_+	hypothetical protein	NA	NA	NA	NA
WP_005885327.1\|1991741_1992020_-	hypothetical protein	NA	NA	NA	NA
WP_005885329.1\|1992082_1993069_+\|integrase	tyrosine-type recombinase/integrase	A0A0E3U2P3	Fusobacterium_phage	5.4e-65	39.4
WP_005885326.1\|1993684_1994677_+	hypothetical protein	A0A0E3U258	Fusobacterium_phage	1.0e-18	29.7
WP_005885324.1\|1994776_1995181_+	M15 family metallopeptidase	A0A2K8GPS6	Shigella_phage	3.2e-24	44.4
WP_040493893.1\|1995194_1995440_+	hypothetical protein	NA	NA	NA	NA
WP_005885321.1\|1995450_1995900_+\|holin	phage holin family protein	M9Q253	Clostridium_phage	8.9e-15	38.8
WP_040493850.1\|1996096_1996300_+	hypothetical protein	NA	NA	NA	NA
WP_005885320.1\|1996530_1997577_+	AAA family ATPase	NA	NA	NA	NA
WP_005885319.1\|1997569_1999798_+	S8 family peptidase	NA	NA	NA	NA
WP_005885318.1\|2000094_2000451_+	hypothetical protein	NA	NA	NA	NA
WP_005885317.1\|2000681_2001563_+	deoxyribonuclease IV	A0A1D6Y7D7	Golden_Marseillevirus	1.6e-15	31.5
WP_005885315.1\|2001625_2002144_+	hypothetical protein	NA	NA	NA	NA
WP_005885313.1\|2002133_2002847_+	hypothetical protein	NA	NA	NA	NA
WP_005885311.1\|2002858_2003365_+	nitroreductase family protein	NA	NA	NA	NA
WP_005885309.1\|2003569_2003902_+	cupin domain-containing protein	NA	NA	NA	NA
WP_005885307.1\|2004150_2004699_-	hypothetical protein	NA	NA	NA	NA
WP_005885305.1\|2004815_2005496_+	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_005885303.1\|2005628_2006606_+\|integrase	tyrosine-type recombinase/integrase	A0A0A8WIE1	Clostridium_phage	1.5e-06	25.6
2011739:2011755	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2287665 : 2293701

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_040494135.1\|2287665_2289171_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	6.8e-67	46.7
WP_005887050.1\|2289182_2289761_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.1e-23	36.9
WP_005887049.1\|2289748_2290750_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FC27	Synechococcus_phage	1.3e-66	45.2
WP_005887048.1\|2290777_2292175_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	1.2e-57	33.6
WP_005887046.1\|2292177_2292891_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	5.1e-41	42.8
WP_005887045.1\|2293221_2293701_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.7e-27	46.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP028102

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection