CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP020818	Bordetella bronchiseptica strain F709 chromosome, complete genome	8 crisprs	csa3,DEDDh,DinG,PD-DExK,cas3	2	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP020818_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_1

425088-425257

Orphan

Consensus_repeat	Method
GTGCCTGTCCCCGCGGGGACAGGC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP020818_1

>merge|NZ_CP020818|1|425088-425257|CRISPRCasFinder
GAGCCTGTACCGGCGCGGGCGGTCAAGCGTCGATGGCGTACGGCAGCGTGCCTGTCCCCGCGGGGACAGGCACCCGGAGCGCTGGGGCGTTCATGGCGCATGACAGAGTGCCTGTCCCCGTGGGGACAGGCGCTCTTGCCGCTGGTGTCGCTCTCCATGCGGGGACAGGC

>NZ_CP020818|1|1|425088-425257|CRISPRCasFinder
GAGCCTGTACCGGCGCGGGCGGTC	AAGCGTCGATGGCGTACGGCAGC
GTGCCTGTCCCCGCGGGGACAGGC	ACCCGGAGCGCTGGGGCGTTCATGGCGCATGACAGA
GTGCCTGTCCCCGTGGGGACAGGC	GCTCTTGCCGCTGGT
GTCGCTCTCCATGCGGGGACAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_010929692.1\|423917_424850_-\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|235707
NZ_CP020818.1\|WP_042997408.1\|433189_434089_+\|virginiamycin-B-lyase	unknown	unknown	gnl\|CDD\|226708
NZ_CP020818.1\|WP_003807706.1\|434762_435689_-\|glyoxylate/hydroxypyruvate-reductase-A	unknown	unknown	gnl\|CDD\|240641
NZ_CP020818.1\|WP_110128944.1\|425307_428103_-\|serine-protease-autotransporter-SphB1	unknown	unknown	gnl\|CDD\|173794
NZ_CP020818.1\|WP_033447985.1\|422464_423805_-\|short-chain-fatty-acid-transporter	unknown	unknown	gnl\|CDD\|224942
NZ_CP020818.1\|WP_003819081.1\|417866_418691_-\|3-oxoadipate-enol-lactonase	unknown	unknown	gnl\|CDD\|131480
NZ_CP020818.1\|WP_003819078.1\|416820_417870_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377240
NZ_CP020818.1\|WP_010929696.1\|419989_420676_-\|3-oxoacid-CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|131482
NZ_CP020818.1\|WP_004566075.1\|421707_422433_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181044
NZ_CP020818.1\|WP_004566074.1\|420805_421657_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|131484
NZ_CP020818.1\|WP_004566077.1\|432486_433035_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP020818.1\|WP_003807710.1\|438484_439345_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
NZ_CP020818.1\|WP_003807672.1\|418691_418988_-\|YciI-family-protein	unknown	unknown	gnl\|CDD\|183800
NZ_CP020818.1\|WP_003819093.1\|428708_431657_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NZ_CP020818.1\|WP_033455252.1\|437280_438285_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NZ_CP020818.1\|WP_003807674.1\|419013_419289_-\|muconolactone-Delta-isomerase	unknown	unknown	gnl\|CDD\|213786
NZ_CP020818.1\|WP_003807705.1\|434113_434740_-\|FMN-binding-negative-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377290
NZ_CP020818.1\|WP_003819100.1\|435697_437284_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173882
NZ_CP020818.1\|WP_010929689.1\|431728_432448_+\|7-cyano-7-deazaguanine-synthase-QueC	unknown	unknown	gnl\|CDD\|284031
NZ_CP020818.1\|WP_003819086.1\|419345_419990_-\|CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_010929692.1\|423917_424850_-\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|235707	PRK06130, PRK06130, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	0
NZ_CP020818.1\|WP_042997408.1\|433189_434089_+\|virginiamycin-B-lyase	gnl\|CDD\|226708	COG4257, Vgb, Streptogramin lyase [Defense mechanisms].	1.99713e-29
NZ_CP020818.1\|WP_003807706.1\|434762_435689_-\|glyoxylate/hydroxypyruvate-reductase-A	gnl\|CDD\|240641	cd12164, GDH_like_2, Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family. This group contains a variety of proteins variously identified as glycerate dehydrogenase (GDH, also known as hydroxypyruvate reductase) and other enzymes of the 2-hydroxyacid dehydrogenase family. GDH catalyzes the reversible reaction of (R)-glycerate + NAD+ to hydroxypyruvate + NADH + H+. 2-hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	2.76987e-137
NZ_CP020818.1\|WP_110128944.1\|425307_428103_-\|serine-protease-autotransporter-SphB1	gnl\|CDD\|173794	cd04848, Peptidases_S8_Autotransporter_serine_protease_like, Peptidase S8 family domain in Autotransporter serine proteases. Autotransporter serine proteases belong to Peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Autotransporters are a superfamily of outer membrane/secreted proteins of gram-negative bacteria. The presence of these subtilisin-like domains in these autotransporters are may enable them to be auto-catalytic and may also serve to allow them to act as a maturation protease cleaving other outer membrane proteins at the cell surface.	5.57747e-75
NZ_CP020818.1\|WP_033447985.1\|422464_423805_-\|short-chain-fatty-acid-transporter	gnl\|CDD\|224942	COG2031, AtoE, Short chain fatty acids transporter [Lipid metabolism].	3.54681e-136
NZ_CP020818.1\|WP_003819081.1\|417866_418691_-\|3-oxoadipate-enol-lactonase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	2.79334e-104
NZ_CP020818.1\|WP_003819078.1\|416820_417870_-\|hypothetical-protein	gnl\|CDD\|377240	pfam04199, Cyclase, Putative cyclase. Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	1.67746e-05
NZ_CP020818.1\|WP_010929696.1\|419989_420676_-\|3-oxoacid-CoA-transferase-subunit-A	gnl\|CDD\|131482	TIGR02429, 3-oxoadipate_CoA-transferase_subunit_A, 3-oxoacid CoA-transferase, A subunit. Various members of this family are characterized as the A subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The B subunit represents a different clade in pfam01144, described by TIGR02428. The two are found in general as tandem genes and occasionally as a fusion.	4.58556e-131
NZ_CP020818.1\|WP_004566075.1\|421707_422433_-\|SDR-family-oxidoreductase	gnl\|CDD\|181044	PRK07577, PRK07577, SDR family oxidoreductase.	2.73809e-71
NZ_CP020818.1\|WP_004566074.1\|420805_421657_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|131484	TIGR02431, p-hydroxybenzoate_hydroxylase_transcriptional, beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family. Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions].	2.55932e-129
NZ_CP020818.1\|WP_004566077.1\|432486_433035_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	1.2238e-64
NZ_CP020818.1\|WP_003807710.1\|438484_439345_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.59886e-34
NZ_CP020818.1\|WP_003807672.1\|418691_418988_-\|YciI-family-protein	gnl\|CDD\|183800	PRK12863, PRK12863, YciI-like protein; Reviewed.	2.55826e-46
NZ_CP020818.1\|WP_003819093.1\|428708_431657_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_CP020818.1\|WP_033455252.1\|437280_438285_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.28148e-69
NZ_CP020818.1\|WP_003807674.1\|419013_419289_-\|muconolactone-Delta-isomerase	gnl\|CDD\|213786	TIGR03221, muco_delta, muconolactone delta-isomerase. Members of this protein family are muconolactone delta-isomerase (EC 5.3.3.4), the CatC protein of the ortho cleavage pathway for metabolizing aromatic compounds by way of catechol. [Energy metabolism, Other].	2.38772e-56
NZ_CP020818.1\|WP_003807705.1\|434113_434740_-\|FMN-binding-negative-transcriptional-regulator	gnl\|CDD\|377290	pfam04299, FMN_bind_2, Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	2.22677e-70
NZ_CP020818.1\|WP_003819100.1\|435697_437284_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173882	cd08517, PBP2_NikA_DppA_OppA_like_13, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP020818.1\|WP_010929689.1\|431728_432448_+\|7-cyano-7-deazaguanine-synthase-QueC	gnl\|CDD\|284031	pfam06508, QueC, Queuosine biosynthesis protein QueC. This family of proteins participate in the biosynthesis of 7-carboxy-7-deazaguanine. They catalyze the conversion of 7-deaza-7-carboxyguanine to preQ0.	1.23474e-93
NZ_CP020818.1\|WP_003819086.1\|419345_419990_-\|CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	1.06634e-114

>NZ_CP020818.1|WP_010929692.1|423917_424850_-|3-hydroxyacyl-CoA-dehydrogenase-family-protein
MDNPIQNLAVVGAGAMGSGIAALFASKGFDVVLIDPMEGALTRAAQVIERQLGVYAPDAIAPAMQRIRMDAGLEAACSAQLVIEAVPEKLALKRDIFARLDTLCDPQAIFATNTSGLSINDIAQAVTRRDRFVGTHFFTPADVIPLVEVVRNDDTSEQTVARVMDMLRAGGKRPVLVRKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLALSGPLEQRDMNGIDVHYAIASYLYQDLENRTTPSELLENKVQAGELGAKSGQGFYAWPPERRERVLRDKSAALAELAAWLENRKPV
>NZ_CP020818.1|WP_033447985.1|422464_423805_-|short-chain-fatty-acid-transporter
MNKLTSFFTELMRKYLPDPFVFAIALTLLTVLMAFGIEGQPLDQITREWGKGFWSLLAFTTQMAVILAMGYVLATAPLTDRLLDRIVSHVHQPRTAIIVATLVGGVGSYLNWGFGLVIGGVVAKKLALKVKGVHYPLIIAAAYSGFTMYGLGLSASIPVLVATPGHPTADQMGVIPLSETIFSLPMLITSLVIIVTLPLLNAWLHPKQGEQVVEVDPAIDQSSAPAKTADELTAEDTLASRLNNSRILSLLIGLLGIAYVVFYFMDGKSLDLNLINFIILFLGIILLGTPAAYVAKLNEGIKTISGIILQYPFYAGIMAIMAGSGLVATISKVFVDVASPGSLPFWGLISSFVINFFAPSAGGHWVIQGPFMIDAAKEIGSALNQTTMAVMLGNAWNDLVQPFWILPALALSKLKLRDVMGYTVIMMLWVGVIHIAAVLAWGYLTH
>NZ_CP020818.1|WP_004566075.1|421707_422433_-|SDR-family-oxidoreductase
MKPTAYLVTGASSGIGAAIARALLDAGHRVVNIDYRLPADAPQGLASYQADLTDEAQTLAVAREVTEAYDIVGLVNNAGATRPGTADTATLADLDYVVALHLRTAMILVQAALPAMRAAGFGRIVNMSSRAALGKPERVVYSATKAGLIGLTRTLAMELGGDGITVNAIGPGPIATELFRNSNPEGAPRTQRIIDSIVVKRLGTPEDVARAAMFFLSPDNGFVTGQVLYVCGGTTLGVAPV
>NZ_CP020818.1|WP_004566074.1|420805_421657_+|IclR-family-transcriptional-regulator
MASRLYNGARSERLHFHLLHTGPMVEQVPQQPGDSYVQSFARGLSVIRAFGPQRPQMTLSEVAAATGLTRAGARRILLTLASLGYVAQEDRRFTLTPRILELGYAYLSATPLWDLALPYMEEVAETTRESCSVSVLDGVDIVYILRLSTHKVMTINLAVGSRLPAWVTSMGRVLLAGLPEAEQDRLLDESQIQPYTPATVVDRAELKRILAGVRVDGYACVVQELEPGLQSVAVPIVDRGGRVIGAMNVSGHANRYSREEMLQAFLPPLRSAAEHINQALRRR
>NZ_CP020818.1|WP_010929696.1|419989_420676_-|3-oxoacid-CoA-transferase-subunit-A
MISKLVATAADALADVPDGATVMIGGFGTAGQPMELIDALLEQGAKDLVIINNNAGNGTTGLAALLGAGRVRKIICSFPRQVDSQIFDGLYRAGKLELELVPQGNLAERIRAAGAGIGAFFTPTGYGTPLADGKETREINGRQYVLEYPLHADYALIQAERGDRWGNLVYRKTARNFGPIMASAARVAVAQVRQVVELGQLDPEAVVTPGIFVKRVVQIDAPRGAKEQ
>NZ_CP020818.1|WP_003819086.1|419345_419990_-|CoA-transferase-subunit-B
MSSKLTRDEIAARVAQDIPEGAYVNLGIGLPTLVANHLPADREVILHTENGMLGMGPAPAKGQEDYDLINAGKQPVTELPGCSFFHHADSFAMMRGGHLDICVLGAFQVSQQGDLANWHTGAPDAIPAVGGAMDLAIGAKDVFVMMELQTRDGQSKLVQACTYPLTGVRCVSRVYTDMAVFDLRAGQITVTDLFGDTTREQLLALTGLPLKFAD
>NZ_CP020818.1|WP_003807674.1|419013_419289_-|muconolactone-Delta-isomerase
MLFMVQMQVNLPPDMPAERADKLKADEKALAQQMQRDGKWRHLWRVAGRYANVSIFDAADNDELHQMLSALPLFPYMDIQVTALARHPSAI
>NZ_CP020818.1|WP_003807672.1|418691_418988_-|YciI-family-protein
MPYIIETFDKPGSLAVRQQHRNAHLQFLDQHKHLLLACGAKLDDDGKDLGGGLYVVDVDTRAAAEQFIQADPFHLAGLFERVAITRWRKAYVDGTSYL
>NZ_CP020818.1|WP_003819081.1|417866_418691_-|3-oxoadipate-enol-lactonase
MSACPGRAGPASGITMSYADLSQARLYYVIDGPADAPVLVLSNSLGTCADMWARQIPELSRRFRVLRYDTRGHGKSSVPDGEYSFAQLGGDVAELLEHLRIERAHFCGLSMGGPTGMWLALERPELIDRLVLCNTAARIGSAEGWSARIAAVRQDGLETMAPGLVERWLTPQYRAAEPGLVQVLVDMLRRIPDAGYMANCAALRDADLRERVAAIRARTLVISSTHDLAATPQDGKALAAAIPGARYVELDTSHISNWEQPEAFTRALTGFLTE
>NZ_CP020818.1|WP_003819078.1|416820_417870_-|hypothetical-protein
MNGMQRWKQRPPGSNWGDFGPDDQLGRLNLITPAEVLKAAQEIRAGRSFCLSLPLDLPGGNVLNPRRHPPQLSPTRLQDTPYVNFPLRNINPDAVDVLSDDQVLLSMQYSTQWDSLAHVGALFDADGDGRAELCYYNGYRAGIDIVGPADADHAGCGCNTGGPSAALKLGIENLAQHSVQGRGVLLDLARHYGAGRTLVGYKELTQALAADGIEIESGDMLVLRTGYAEAVVGMNGKPDADALHQYGAALDGTDAELLQWITDSGIAAICADNYAVEAYPARERQGPRAMLPLHHHCLFKLGLPLAELWYLKDLAEWLHANGRHRFMLTAPPLRLPHAIGSPVTPVATV
>NZ_CP020818.1|WP_110128944.1|425307_428103_-|serine-protease-autotransporter-SphB1
MPPPAVPPQLPEVPAADLPRVRAPLSTYRRPQRTDFVTPAGGPFFAKQDKALNTIDLKMAHDLKLRGYRVKVAVVDEGVRSDHPHLNVEKKYGGDYMADGTRTYPDPKRQGRHGTSVALVLAGQDTDTYRGGVAPNADLYSANIGTRAGHVSDEAAFHAWNDLLGHGIKIFNNSFATEGPEGEQRVKEDRNEYQRAANKQNTYIGRLDRLVRDGALLIFAAGNGRPSGRAYSEVGSVGRTPRVEPHLQRGLIVVTAVDENGRLETWANRCGQAQQWCLAAPSTAYLPGLDKDNPDSIHVEQGTSLSAPLVTGAAVLVQDRFRWMDNDNLRTTLLTTAQDKGPYGVDPQYGWGVLDVGRAVQGPAQFAFGDFVARVTDTSTFGNDISGAGGLVVDGPGALVLAGANTYAGRTTIKRGTLDVFGSVTSAVTVEPGGTLTGIGTVGTVTNQGTVVNKEAGLHVKGDYSQTAQGLLVTDIGSLLDVSGRASLAGRLHVDDIRPGYVGGDGKSVPVIKAGAVSGVFATLTRSPGLLLNARLDYQPQAVYLTMRRAERVHAAAQRGADDGRRASVLAVAERLDAAMRELDALPESQRDAAAPAAAIGRIQRVQSRKVLQDNLYSLAGATYANAAAVNTLEQNRWMDRLENHLAQAGGERVAAIAEYRHGQLRWRPDGLQGRQRGNGIMLGLAREVSAGLSLAAALTHSRTHWDESSGAPARDNAAMTTPGVLLGARRAWEDGWFVQGALGYSRYRNQATRHISLGDAGHTVGATARGHVWQADAGLGRQWTLAPGHTLAPRAGLQLTHLRQQGFSESGAQGLGLRAHALTRTVPTLWAQLQSRHAFMLGATPMTAQLQLGVWHDLRARRYAASGGFAGLAQDQGASGYWPVPRTRVQGALGLRAEFAPGLALGLGYTGQLATHWVDHQLSASLTYRY
>NZ_CP020818.1|WP_003819093.1|428708_431657_-|phosphoenolpyruvate-carboxylase
MAAYNAPVSNCQFRLTHILPIPQRHGAPTDPFQMNAIRQQSDSAEPLRHDIRLLGRCLGEVIQACEGKRVYDTIETLRRTAVRFRRAGDPADDKLLQARVKQLRGNDPNSVARAFSYFLHLSNIAEDRDQNRRQRERALAGAGPERGSLRQAIESLKAQGVNNARIRRLLSEACVMPVLTAHPTEVQRKSTLDVHREISSLLVQRERELTADELSELDLALIGQVATLWQTRMLRYTRLTVADEIENALSYYRSTFLNVIPRVYGDLARLLNREPVKPFTPPPPPLEPFLRMGSWIGGDRDGNPNVDAATLERALLRQATVLFEHYLQEVHALGAELSASTLLIEADPALLALADAGGDDSPHRRDEPYRRALIGIYARLAATARHLTGQELARRATVPAAPYDTPDALAADLAVIAASLSARHGAPIARLRLSGLQQAVTVFGFHLATVDLRQSSDVHERVLAELFARAGDGIDGQAVDYLALDEAARVAVLRRELAHARPLASPWIAYSEETASELAVLRAAAAGRARYGRQAVLQSIVSHTETLSDLLEVLVLQKEAGLIAPPGETIAPGDGLMVVPLFETIPDLQRGPEIMAAWLDLPEVRQRVRLAQGDTQEVMLGYSDSNKDGGFLTSNWSLYQAERALVDVFSARSVRLRMFHGRGGSVGRGGGSSYDAILAQPPGTVAGQLRLTEQGEVIQSKYKDAEVGRWHLELLVAATLESSLAPQAAATSAEDAHMQQHAPAMSFMSELAQRTYRGLVYDTPGFADYFFAATPISEIAGLNIGSRPASRKKGQHIEDLRAIPWGFSWAQCRLMLTGWYGMGSAIEAYLETGAQGAPRSRRARLAQLREMASDWPAFRTLLSNMEMVLAKSDLAIAAGYAQLVPRRGLRERVFGAITAEHGRTLAMLRLLTRRDLLADNPGLMASLRERFAYIDPLNYLQIELIKRHRAAQRRAGDDADIRVPRAIHLTINGIAAGLRNSG
>NZ_CP020818.1|WP_010929689.1|431728_432448_+|7-cyano-7-deazaguanine-synthase-QueC
MQNHQRRALVLFSGGQDSTTCLAWALERYAHVETLGFDYGQRHRVELDARQVVLRELRANFPDWAQRLGDDHLLDLGILAQVGDTAMTSDREIEMQANGLPNTFVPGRNLLFLTLAAALGYRRQLDVLVGGMCETDFSGYPDCRDDTIKSQQVTLGLGLGTRVTIETPLMWLDKAQTWELADRLGGQALVDMVIEHSHTCYLGERGQRHDWGYGCGHCPACALRKNGWERWVAGAAHAD
>NZ_CP020818.1|WP_004566077.1|432486_433035_-|N-acetyltransferase
MTASTPTAILIRDSRDADLPAIAAIYAHHVLHGTASFELEPPGLEALRERRAAVLAHGLPYLAAECGGEIVGYAYATPYRPRPAYRHTVEDSVYVRAGHAGLGIGGKLLAALIERCAAGGWRQMLAVVGDSANTASVALHARHGFDTIGTFRSVGYKHGQWRDTVLMQRALGEGDATPPSRP
>NZ_CP020818.1|WP_042997408.1|433189_434089_+|virginiamycin-B-lyase
MNQVKMTEFPVGKPEEALYGVASTPDGALWFTLAKGNAIGRLSPDGEVSRFPLPHADGQPTTITCGPDGRPWFTLSSANAVGRLSPDGALRMFELPRPASRPFGIAAGHDGCLWFAEMAGDRIGRITIDGDIEEYDLPVKGGYPSCIAAGRDGLMWFTLNQAGAIGSISATAAPRIFPLGAADAAPVGIASDAQGALWIAQAGNGAIARFDAGGRITEFPLHSRAARPHAIAADAAGNLWFTEWGANRIGRISEAGDPAGYELAAPGSEPHGIAIDPHGCVWAALETGSLVRLQALPRD
>NZ_CP020818.1|WP_003807705.1|434113_434740_-|FMN-binding-negative-transcriptional-regulator
MYTPPAYEERDRHKLHAWMRDWSFATLVTHGDQGLQATHLPFLLDPLRGPHGTLISHLARRNPQAADIQAGAQAMVVFQGPHAFISPSWYRNRQTFPTWNYAAIHAHGQAAAIEDAQRIRAILTRTVQTYDTPLGGEWTFEAMPEDLIVPRLSAIIALEIPIARLEGKVKLNQDKSPEDRAGVLAALENRRDPGSRGVARMMREALLA
>NZ_CP020818.1|WP_003807706.1|434762_435689_-|glyoxylate/hydroxypyruvate-reductase-A
MTLIAIASQAPDLLRLPPALRALDPSIDVVVWPDPRCAAAEVAVCWAPPPGALAAMPALRLLHTVSAGVDNVLAAPGLPDVPLCRVVDAELNLGMAQYILWGALYFSRGFDQARASQAAGQWRRPDRYGQPPLRVGLMGLGAIGMAALPLLRAAGLPVTGWSRTAKRIDGVATHHGPDGLAPFLAASDILVNLLPLTESTRGLLCAATFAGLPPGAALIHCGRGAHLVEADLQAALADGRLRGALVDVYAQEPLPPQHPLWRCPSLVITPHMASVAPFERVAGQILENLRRLNAGEALMNLVDPRRGY
>NZ_CP020818.1|WP_003819100.1|435697_437284_-|ABC-transporter-substrate-binding-protein
MNYRHIRGTLRALLLASAAIATLAGAPAQAQTRGGTLRAIVHPEPPILITAINSQSPTQFVGGKIFQGLLTYDADLKPQPSLARAWRISPDGLVYTFELQPDVKWHDGKPFSADDVVFSIDKLVREVHPRTKLILNAYVESVRAVDPATVEIRLKEPFAPFISMFETGTMPMMPKHLYEGTDYRNNPANQHPVGTGPFKFKEWVRGSHIALVRNDEYWKPGLPYLDGIRFQVIPDSASRAVAFEQANVDLVYGDDVDSVDIKRLRALPGVQYTTKGWEMFGPMGLMVLNQREAPFDNVLVRRAVMHALNRDFIVKNIFFGMGRVPTGPFSSATLFHDKDLPVYDYNIKKARALIKESGVDVGQRTLRLLAFPYGANWERVGEYTRQTLEQLGFKVDIQATDAGGWASRMSQWDFDISFNHPYQYGDPVLGVQRLYLSSNRVKGTPFGNNQGYHNPKADALWQQAARSVDPAERQKLYSELQRILVDDAALGWLLEIDYPTLYRGNVHNLVTSAIGVKESFDTVYLDAR
>NZ_CP020818.1|WP_033455252.1|437280_438285_-|alpha/beta-hydrolase
MTTAALPYPLDPQIQRFVERMQADSAAHPRRDLVPVEQARAISEAVRRPWAEGGPQMARTREIHVPTPHGPVRLRVYTPRAARPGPALLYVHGGGWVLFSLDTHDRLMREYAERAGLTVIGVDYTRAPEARYPRAIEEIVGVIDWLDANGAELEVDRARLCIGGDSAGANLSVAACLTLRERGAAPLAGMVLNYGVYDANLFRDSTVKYGGGEYLLSTQQMVWFYWNYLRAGDDPRDPRISPVHADLRGLPPAFMAITELDLLHDANQDMAARLREAGVDVQAKVYPGTVHSFLEAVSLAQVSVAAFDDTAAWLRAVLRPDAAAAAIHTGEHQP
>NZ_CP020818.1|WP_003807710.1|438484_439345_+|helix-turn-helix-transcriptional-regulator
MPAIAKDPSPRRAPAFPAPRQLSYLDLLTRQVQSAPGEMAALATDYPAGTVSSLHRHDRGQLLYAMSGVVTVITDLGSWVVAPGQALWIAPGVLHQTRGFESVAIRSLYIDPAHADGLPAACQTIQVSPLLQALILEAVKLPPQDAGSERAGHIRALILDEMRHVCAAPLYVPMPRDARLARICQALLRDPANAGSLDAWAAYGGLSRRNLTRLFRAQTGASFNAWRQKVLLMEALARLSRGEQITAVALDLGYGSPGAFTAMFRRALGVSPREYFRWTEAPQRAD

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Crispr_ID: NZ_CP020818_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_2

1273512-1273586

Orphan

Consensus_repeat	Method
CGCCGCGCTGCACGGTGCCTGTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020818_2

>merge|NZ_CP020818|2|1273512-1273586|CRISPRCasFinder
CGCCGCGCTGCACGGTGCCTGTCCCAACGGGGACAGGCACCCGGATGCCACGCCGCGCTGCACGGTGCCTGTCCC

>NZ_CP020818|2|2|1273512-1273586|CRISPRCasFinder
CGCCGCGCTGCACGGTGCCTGTCCC	AACGGGGACAGGCACCCGGATGCCA
CGCCGCGCTGCACGGTGCCTGTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_003819635.1\|1265835_1266858_-\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270321
NZ_CP020818.1\|WP_010927811.1\|1268780_1269071_-\|metal-binding-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_003819659.1\|1283993_1284920_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP020818.1\|WP_003809146.1\|1283617_1283971_+\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|238008
NZ_CP020818.1\|WP_033466136.1\|1267563_1267983_-\|cyclase	unknown	unknown	gnl\|CDD\|273970
NZ_CP020818.1\|WP_042996968.1\|1266892_1267513_-\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
NZ_CP020818.1\|WP_042996966.1\|1275153_1276161_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NZ_CP020818.1\|WP_003809136.1\|1277949_1278282_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_051644174.1\|1269067_1269703_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378278
NZ_CP020818.1\|WP_110128997.1\|1273763_1275152_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP020818.1\|WP_004568287.1\|1268215_1268743_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_CP020818.1\|WP_003809130.1\|1271595_1272099_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319910
NZ_CP020818.1\|WP_004568284.1\|1270834_1271494_-\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP020818.1\|WP_015041174.1\|1281480_1282515_-\|polysulfide-reductase-NrfD	unknown	unknown	gnl\|CDD\|184954
NZ_CP020818.1\|WP_042996967.1\|1272266_1273424_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP020818.1\|WP_003809128.1\|1269699_1270776_-\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	unknown	unknown	gnl\|CDD\|185333
NZ_CP020818.1\|WP_003819653.1\|1276171_1276318_+\|DUF2474-family-protein	unknown	unknown	gnl\|CDD\|371167
NZ_CP020818.1\|WP_003819654.1\|1276334_1277756_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP020818.1\|WP_110128998.1\|1278292_1281454_-\|tetrathionate-reductase-subunit-TtrA	unknown	unknown	gnl\|CDD\|237883
NZ_CP020818.1\|WP_003819657.1\|1282528_1283302_-\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|184955

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_003819635.1\|1265835_1266858_-\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270321	cd13603, PBP2_TRAP_Siap_TeaA_like, Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP) and related proteins; the type 2 periplasmic-binding protein fold. This subfamily includes the periplasmic-binding component of TRAP transport systems such as SiaP (a sialic acid binding virulence factor), TeaA (an ectoine binding protein), and an uncharacterized TM0322 from hyperthermophilic bacterium Thermotoga maritima. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.76567e-123
NZ_CP020818.1\|WP_004568284.1\|1270834_1271494_-\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	1.35503e-52
NZ_CP020818.1\|WP_003819659.1\|1283993_1284920_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.03606e-26
NZ_CP020818.1\|WP_003809146.1\|1283617_1283971_+\|EF-hand-domain-containing-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	6.77115e-08
NZ_CP020818.1\|WP_033466136.1\|1267563_1267983_-\|cyclase	gnl\|CDD\|273970	TIGR02096, putative_cyclase, conserved hypothetical protein, steroid delta-isomerase-related. This family of proteins about 135 amino acids in length largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes.	3.07944e-52
NZ_CP020818.1\|WP_042996968.1\|1266892_1267513_-\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	6.60866e-76
NZ_CP020818.1\|WP_042996966.1\|1275153_1276161_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	1.62612e-99
NZ_CP020818.1\|WP_110128998.1\|1278292_1281454_-\|tetrathionate-reductase-subunit-TtrA	gnl\|CDD\|237883	PRK14991, PRK14991, tetrathionate reductase subunit TtrA.	0
NZ_CP020818.1\|WP_051644174.1\|1269067_1269703_-\|hypothetical-protein	gnl\|CDD\|378278	pfam09859, Oxygenase-NA, Oxygenase, catalyzing oxidative methylation of damaged DNA. This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.	1.99547e-49
NZ_CP020818.1\|WP_110128997.1\|1273763_1275152_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_CP020818.1\|WP_004568287.1\|1268215_1268743_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	1.38579e-12
NZ_CP020818.1\|WP_003809130.1\|1271595_1272099_-\|VOC-family-protein	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.40007e-55
NZ_CP020818.1\|WP_003809128.1\|1269699_1270776_-\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	6.29763e-138
NZ_CP020818.1\|WP_015041174.1\|1281480_1282515_-\|polysulfide-reductase-NrfD	gnl\|CDD\|184954	PRK14992, PRK14992, tetrathionate reductase subunit TtrC.	7.99868e-43
NZ_CP020818.1\|WP_042996967.1\|1272266_1273424_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	6.24103e-80
NZ_CP020818.1\|WP_003819653.1\|1276171_1276318_+\|DUF2474-family-protein	gnl\|CDD\|371167	pfam10617, DUF2474, Protein of unknown function (DUF2474). This family of short proteins has no known function.	2.47299e-05
NZ_CP020818.1\|WP_003819654.1\|1276334_1277756_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.75526e-136
NZ_CP020818.1\|WP_003819657.1\|1282528_1283302_-\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|184955	PRK14993, PRK14993, tetrathionate reductase subunit TtrB.	3.36133e-131

>NZ_CP020818.1|WP_042996967.1|1272266_1273424_-|metallophosphoesterase
MSLRRSAFFIRFLTLGALAHVYVGARLIPDAGLPAAGVAAAILALCASCVLIPLGMASHASGRQPWGDRLAAVGLVAMGYFSSLFVLTVLRDAALLLAWLAGLAALPVPMDALRAASAPAVPLLALAATLLGLANARRRARVVTVDVPIDALPAALQGYTIVQISDLHVGPTIKRRYLQAIVDAVNAAGPDLVAVTGDVVDGPVAHLSPHTQPLAALRAPDGVYLVTGNHEYYSGAAAWVQEFRRLGLCVLQNEHRVVRRGDAALVVAGVTDYGAAAFDASQRSNPAQALAGAPAKAAVRLLLAHQPRSAAAAAPLGYTLQLSGHTHGGQFLPWNWFVRLQQPFTAGLHRYGPMWVYTSRGTGYWGPPKRLGAPSEITRVRLVRA
>NZ_CP020818.1|WP_003809130.1|1271595_1272099_-|VOC-family-protein
MATAVKPIPEGMHTLTPHIICAGAARAIDFYIKAFGAVEMARLAGPDGRLMHGAVRIGDSTLMLMDAFPEWDTPDPKALNGTPVVLHLYVEDVDAAHAQAVAAGATSVMPVTDMFWGDRYGQVRDPFGHLWSIATHKQDLTPEQIAEAARNAPPCPDVAEQAGKARE
>NZ_CP020818.1|WP_004568284.1|1270834_1271494_-|DNA-3-methyladenine-glycosylase-2-family-protein
MTAATLSPAAYAHAERFLAGLDADWRGHVAATGPCLHRPLPAREPYEALVRAIAYQQLHARAGDAIVGRLLALFPGGAFPAPGQLLAADPAALRACGFSAAKTQTILGIAQAARDGVVPDRRAARRMSDQALVERLTTLRGVGRWTVEMLLIYTLARADILPADDFGVRDGYRRLKGAAATPTARQMRDIGQAWGPYRTLAAWYLWRVPPEARIRAQET
>NZ_CP020818.1|WP_003809128.1|1269699_1270776_-|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada
MNLPVRPAPAYATPEARWAAVQARDPAADSHFVYAVRTTGVYGRPSSAARLPRRENVEFFDNAEAARAAGYRPSRHNAADRTVTARQHSALVAAACRHIEQADTPPTLEALAAHVGLSPFHLHRLFKAETGLTPKAYASAQRARRLRAELGESASVTAAIYDAGFNSNSRFYEASQQLLGMAPRAYRAGGANARIRFAVAQCALGAILVAQSQLGICAILLDDDPDYLVRQLQDLFPRATLIGGDAGFERLVAEVVGFVEAPALGLNLPLDVRGTAFQERVWQALREVPPGATVSYTDIAERIGAPKAVRAVAQACAANRIAVAIPCHRVVRRDGDLSGYRWGVDRKRELLRREAATP
>NZ_CP020818.1|WP_051644174.1|1269067_1269703_-|hypothetical-protein
MTPVLTPGILQAGATAIAALDRAALHARLDRDGWALLPALFDAPAIAALLACAPPQGPGIAAGVFAPLRAALYAQLAPLANAWAQTLQTGWRYPASAPAGVPPDIRLDVVETGHARPLTQHEPAPDVFPLQLVVLLSDPKRDFAGGELVLTEQRPRMQSRPIVIPLRQGDAALIPTAHRPCRGAHGFYRASLRQAISPVRAGRRVGLALLP
>NZ_CP020818.1|WP_010927811.1|1268780_1269071_-|metal-binding-protein
MSPSARRWRLIGADGQPLLSAEPGTLGGHRRGRLYGRLDCRAAARALARGGYAAQRVFFLDEASAVAAGYRPCAVCMPQAYAAWKTARAHKRAAME
>NZ_CP020818.1|WP_004568287.1|1268215_1268743_-|hemerythrin-domain-containing-protein
MSSAFPAPAPDFDQPLQLLAACHGRIERQCATLERLAAHLRAQGSDDAARTAAASVMRYFDSAAVKHHEDEEQDLFPALIESMAGSDAVCLRQLVGSLTDEHRALGSAWRRVREVLQQVADGQGAAFAPGQAEDFVAAYRAHLRREDEELLPLAERLLDDGALADMAQAMRDRRS
>NZ_CP020818.1|WP_033466136.1|1267563_1267983_-|cyclase
MTWRVDLIAQHIEVENRHLMDEMLATLADENPVRDEVAGRVYRGKDEVAARYAELWQAFPDFNVRPVRYTEQEGIVVMEAIYTGTHHGAYLGLPGSGKSFNVRLVNVFGFDDERIESETIYIDLAGQLRQLGITAIPRN
>NZ_CP020818.1|WP_042996968.1|1266892_1267513_-|2-hydroxychromene-2-carboxylate-isomerase
MHIDYYFSVVSDWAYFGGERLERLARRHGATIRHKPMQLSAVYAQTGGILLQQRSTQRQAYRVTELERWRDHLGIPITLHPRHYPVDDIPASCAILAAQELGMATGDYANAVLRAIWTQERDISDSRTLDEIARGLGLDADAILQLAQAPHIRQRLADNTREAIGHGVFGSPFYLCNGHLFWGQDRLPFLEDVLAGRVGAYAGAPA
>NZ_CP020818.1|WP_003819635.1|1265835_1266858_-|TRAP-transporter-substrate-binding-protein
MLRTARTTLAIIAAATLLAACDKGGADRPQAASGAQPRTLQLAHVSVENEDDMYHHLAAGFAERVARHTDGAVKVQVLGGAQLGGERDVAEGMQLGSIDMSVIASFALGAFEKKAMIFDLPYLFKDYPTAFQALDSSFTDGIEADLEKTGLKVLGWGHGGFRNLYNSKQPIRTLADLKDMKVRMPENPIYVDTWRALGVNVTSMAYPELFTGLQQRTIDGAENPTALYYTSRFYEAAKYLSKTEHVYVAIPIVVSARIWTSLAPEQQAAFQQAADEAIAAQRQFLLATEAATEKKLAEAGVAINTDVDKAAFRQAAAPVYERYRNTIDPELVNRAQALAQ
>NZ_CP020818.1|WP_110128997.1|1273763_1275152_+|cytochrome-ubiquinol-oxidase-subunit-I
MMSSEALLLARIQFGFTISFHIIFPAITIGLASYLAVLEGCWLRTRDTVYRDLYHFWSKVFAVNFGMGVVSGLVMAYQFGTNWSAFSEFAGSITGPLLAYEVLTAFFLEAGFLGVMLFGWSRVGPRLHFFSTIMVALGTLVSATWILASNSWMQTPAGYEIVDGRVVPVDWLAVIFNPSFPYRLAHMGIAAFLATALLVAASGAWHLLRGHRTPAVRRMFAMALGMLAIAAPLQAVVGDMHGINTLKHQPAKIAAIEGHWENVPGEGVPLHLFGVPDMQAETTRYALSVPRLGSLILTHSLDGQFPGLKSYPPADRPNATVVFWSFRVMVGLGLLAIALAAWAGWARLRGRLYDSRALQRFALAMGPSGLVAILAGWYTTEIGRQPWIVQGLMRTADAATPHGVPALTLTLLLFVFVYLIVFGAGIVYVLRLIARGPSGGAPAGGQPGLVQRPLAAAPQGGL
>NZ_CP020818.1|WP_042996966.1|1275153_1276161_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MGVDLSLIWAIIILFGVMMYVVMDGFDLGIGVLFPLLPGKSDRDVMMNTVAPVWDGNETWLVLGGAGLLAAFPRAYAVVLGALYLPLVFMLLGLVFRGVAFEFRFKADEHHRPFWDRAFIGGSVAAAFFQGAALGAYLQGIELVDGAYQGGPWGWVTPFSLFCGAGLVVAYALLGCTWLIMKTEGALQRRMIVVARPLTGALLAVIAAISVWTPLIEPAIARRWFSLPNFYAFAPVPVLVLAAAWGLLRALRGQPDMAPFLLTLALVFLGYSGLCISLWPHAIPPGVTLWEAAAPPQSQGFALVGALFIVPVILTYTAWSYYVFRGKVRAGDGYH
>NZ_CP020818.1|WP_003819653.1|1276171_1276318_+|DUF2474-family-protein
MTEDTLDRPASTLRRLGWLALLWAGGVAGLGLAAGGLKLIMKLAGLTP
>NZ_CP020818.1|WP_003819654.1|1276334_1277756_+|PLP-dependent-aminotransferase-family-protein
MKLKRYEVLADEITASIQAGTRRAGDRLPSVRQTSASRGLSATTVFKAYYLLEARGLIRARDRSGYYVVGKPKALPPELEAGAPAESRRVDVDVSDRVLHVLQLTMRRDVVPFGSAFPHPSLFPHARLARAMASSVAALDPWSSVDDLSAGNTRLRRAIALRYLADGVQVRTEDIVITNGALEALNLCLGAVTRPGDSVLIESPTFYSALQSLERLGLRAIEVPAHPREGIELDALARAIDTHRPAACWLMTNFQNPLGSLMPEDKKRALVELLAARDVPLIEDDVYSELYFGAQRPLPAKAYDESGIVMSCSSFSKSLAPGWRIGWVLGGRYADRILRGKLALSLSTSAPSQAALATYLEHGGYDRHLRQLRQTLEQQRNQVMEAIARHFPPGTRTTHPDGGYFLWVALPPQVDALAVHRAALSLGVSTAPGPIFSVQDRFRHCLRLNYGHPFDARAQDGLATLGKLIARQC
>NZ_CP020818.1|WP_003809136.1|1277949_1278282_+|hypothetical-protein
MYRGHEAIKQFMQAIGLPWTPGQAESAELRASYRIGSGRPLNIDRTRVEFHCDDARAKVWVPEFARTSFHQWFEVAYQDFEYAPGASMLKIKAAARGNAAAYSVGLKPLA
>NZ_CP020818.1|WP_110128998.1|1278292_1281454_-|tetrathionate-reductase-subunit-TtrA
MPKQHPTPDTDAPADARRRKLIARGGAVAGGMAAFAAGYGETVARAVKGLAQGSAGAPTADALRGNSLTPEFRIDPVTGALSAQPGQTVSPSSCLGCWTQCGVRLRVDTETNRILRVAGNPYHPLATTQPAPMHAPVREVYARLGGDNGLEGRATSCARGSAMLEQLTSPYRVLQPLKRVGPRGAGQWRTISFEQLVEEVCEGGDLFGEGHVDGLRAIYDPVTPLDPDNPEYGPRSNQLLFTDSANEGRTPLIQRFAAQSFGTVNVSNHGSYCGQSFRVGTGAAFGDLKGMPHGKPDWTRARFGLFIGTAPAQSGNPFQRQGRQLAEARVRDDGAGFHYVVVSPVLPASASLAAGSGNEWLAVNPAGDLALVMGMIRWILEHGRYDAAMLSQPGPAAMDAAGEAAWTNATHLVIDAPGHARHGSCLRGADLGWPRAGADPQAEDVYVVQRPDGTLAPHTHAGPAALFVERDLPAAGVAPGLGGVRASSALALLRREARRMTLDDYALHSGVPAARIAGLAERFTSHGKQAVADAHGGTMSGAGFYTAYAIAMLNTLVGNLNVAGGLVLDGGPFAPYGKGPRYDIAGFAGRVAPRGVSLSRNRFPYEKSSEYRRKAEAGQSPYPAQSPWYPATGALSSEMLASALAGYPYRAKVWLNHMSNPVYAIAGLKNVIADKLRDPGLLPLSVSINAFINETNALADYIVPDTITYESWGVSAPWADVQAKASTVRWPAVAPRVARTANGEPVCLESFLIACAKRLDMPGFGADAIAGRDGRRHALDTASDFFLRGMANMAYAGGAPVAEASEDDLALTGVDRHADLLRRTLQDDEWRRVALLMSRGGRFDAAEDVWRDGRVHPPYRKPLHVWSEDLARMRHAMTGEPYSGCPTWYPTRLADGRAMREQYPQADWPFLLSSFKSNLMSSMSIGVSRLRQVHPHNPVSISRADASRLGIGNGDAVRIVTPGGAVTGLALVRDGVQPGAIAIEHGYGHTELGARAHVVDGRPMPHDPALAAGVNLNDLGFGDATRALRDNVWIDWVSGAAVRQGLPARLEKA
>NZ_CP020818.1|WP_015041174.1|1281480_1282515_-|polysulfide-reductase-NrfD
MRISELITPVYDAAWLPWAVQYFFLIGISAATALTAAACAFGRPGSARARLLPAAIAVLAVSAVAAPVSLLADLHQPGRFWHFYTQATPWSWMWLGALLLPLYAALALGLCAAWWLGWRRAMRALAVPLALSALSILVYTGSEVMVLRSRPLWHTVFLPINFALTGWLGALGAMLLLGRWLPGGLAAVPMALLRRLAMAALAALAASAGAWAVLGLLGHEPSFDAALRLFAQFPAWRASLAGAIATGLCMAALLQMRPARLAGPAASLALALTLLAAAWIFRWVVFMNVQGVPKYGAGLYLYDMPWGSDGLLGMAGVLGLCVALVAALAWALERFPARTAAPAR
>NZ_CP020818.1|WP_003819657.1|1282528_1283302_-|4Fe-4S-dicluster-domain-containing-protein
MHNAPSSDRPPAPGKRGFLKELLGLAATATVIPIAPEARAGMNAQPPRRPGAAGKRYGMVVDLRLCIGCQACTVSCSMENLPPIGQFRTTVLQYEVLPDDGGPCSMVMLPRLCNHCDNPPCVPVCPVQATFQREDGIVLVDNERCVGCGYCVQACPYDARFINHETQTADKCTFCEHRLEAGLLPACVESCVGGARVIGDLNDPASAVSRLLAEHRDEVKVLKPDMRTDPHVYYIGLPDAFVNQIDGQAGVRLAGRH
>NZ_CP020818.1|WP_003809146.1|1283617_1283971_+|EF-hand-domain-containing-protein
MKKTIIASAACAALLATSGAVLAQSGASLTPDQLQHLDTDKSGGVSQKEYQAFMEASFAKLDANGDGSLTRQELPQEVSDAQFTAMDANKDGRVSRQEFLGQVMRDFATASRGGELK
>NZ_CP020818.1|WP_003819659.1|1283993_1284920_-|alpha/beta-hydrolase
MTQSSQTTSPSADAHVKHRYLDLDELRIFYREAGPADAPVVLLPHGYPCSSFQYRDFMPALADQWRLLAPDFPGFGYSDTPDTARFACDFEHYTDFLQQFAHALGLPSYALYLHDYGSQIGLRLAMREPDKVSGLIIQNGDIYEDELGPRYAPLQAYWADPTLEGRYKLSLAVSEEGFRDEFLNDLPEEQAECITPDMWKLAWALLREPRRREIMVGLMEGLEDNLAWFPRYQAYLRERQPPTLIVWGVHDGYMPEAAARAYLRDLPDAELHLLQAGHWALETHLAPIVALTRAFLQRVHATPNFPPP

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Crispr_ID: NZ_CP020818_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_3

1407009-1407139

Orphan

Consensus_repeat	Method
CTGTCCCCGCGGGGACAGGCACACTG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP020818_3

>merge|NZ_CP020818|3|1407009-1407139|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACTGCCGTACGCCATCGACGCTTGACCGCCAAGACGGTATCTGTCCCCGCGGGGACAGGCACCCTGGCCGGCGGGCCAGGATCGGGCATCCACGGGGACAGGCACCCTG

>NZ_CP020818|3|3|1407009-1407139|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACTG	CCGTACGCCATCGACGCTTGACCGCCAAGACGGTAT
CTGTCCCCGCGGGGACAGGCACCCTG	GCCGGCGGGCCAGGATC
GGGCATCCACGGGGACAGGCACCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_003819789.1\|1406171_1406813_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP020818.1\|WP_003819779.1\|1396256_1397684_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP020818.1\|WP_003809398.1\|1395237_1396260_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP020818.1\|WP_003819780.1\|1397840_1398569_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239483
NZ_CP020818.1\|WP_003819788.1\|1404644_1406081_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|224938
NZ_CP020818.1\|WP_003809431.1\|1411936_1412653_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_003809411.1\|1398859_1399795_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP020818.1\|WP_033459324.1\|1410250_1411672_-\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|182606
NZ_CP020818.1\|WP_003809432.1\|1412737_1413055_+\|DUF883-domain-containing-protein	unknown	unknown	gnl\|CDD\|377576
NZ_CP020818.1\|WP_080704246.1\|1417734_1418475_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_003819799.1\|1416405_1417560_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|180937
NZ_CP020818.1\|WP_004568238.1\|1402280_1403417_-\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NZ_CP020818.1\|WP_110129006.1\|1407424_1410184_+\|pertactin-autotransporter	unknown	unknown	gnl\|CDD\|273608
NZ_CP020818.1\|WP_003819794.1\|1413095_1413509_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377816
NZ_CP020818.1\|WP_033459982.1\|1413912_1415457_-\|UbiD-family-decarboxylase	unknown	unknown	gnl\|CDD\|236796
NZ_CP020818.1\|WP_004568237.1\|1403413_1404487_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NZ_CP020818.1\|WP_003809436.1\|1415540_1416371_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381594
NZ_CP020818.1\|WP_003809416.1\|1401791_1402136_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518
NZ_CP020818.1\|WP_003809414.1\|1399844_1401725_-\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP020818.1\|WP_003819796.1\|1413510_1413870_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_003819789.1\|1406171_1406813_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	6.55206e-126
NZ_CP020818.1\|WP_003819779.1\|1396256_1397684_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP020818.1\|WP_003809398.1\|1395237_1396260_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	4.19811e-141
NZ_CP020818.1\|WP_003819780.1\|1397840_1398569_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239483	cd03389, PAP2_lipid_A_1_phosphatase, PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.	6.13555e-75
NZ_CP020818.1\|WP_003819788.1\|1404644_1406081_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	2.7893e-89
NZ_CP020818.1\|WP_003809411.1\|1398859_1399795_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	7.49349e-144
NZ_CP020818.1\|WP_033459324.1\|1410250_1411672_-\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|182606	PRK10637, cysG, siroheme synthase CysG.	1.43865e-175
NZ_CP020818.1\|WP_003809432.1\|1412737_1413055_+\|DUF883-domain-containing-protein	gnl\|CDD\|377576	pfam05957, DUF883, Bacterial protein of unknown function (DUF883). This family consists of several hypothetical bacterial proteins of unknown function.	1.02514e-26
NZ_CP020818.1\|WP_003819799.1\|1416405_1417560_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|180937	PRK07337, PRK07337, pyridoxal phosphate-dependent aminotransferase.	0
NZ_CP020818.1\|WP_004568238.1\|1402280_1403417_-\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NZ_CP020818.1\|WP_110129006.1\|1407424_1410184_+\|pertactin-autotransporter	gnl\|CDD\|273608	TIGR01414, Contains:_AIDA-I_translocator, outer membrane autotransporter barrel domain. A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	6.43022e-113
NZ_CP020818.1\|WP_003819794.1\|1413095_1413509_+\|phage-holin-family-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	2.48727e-14
NZ_CP020818.1\|WP_033459982.1\|1413912_1415457_-\|UbiD-family-decarboxylase	gnl\|CDD\|236796	PRK10922, PRK10922, 4-hydroxy-3-polyprenylbenzoate decarboxylase.	0
NZ_CP020818.1\|WP_004568237.1\|1403413_1404487_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NZ_CP020818.1\|WP_003809436.1\|1415540_1416371_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	5.91272e-19
NZ_CP020818.1\|WP_003809416.1\|1401791_1402136_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	5.53938e-43
NZ_CP020818.1\|WP_003809414.1\|1399844_1401725_-\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	0

>NZ_CP020818.1|WP_003819789.1|1406171_1406813_+|uracil-phosphoribosyltransferase
MPVHEIRHPLIRHKLGIMRRADLSTKSFRELSQEVAALLTYEATKDMPLAPASVEGWCGTVEVDKIAGKKVTVVPILRAGIGMLDGVLSLIPGAKVSVVGVARNEETLQAHTYLERLVGELDQRLALIVDPMLATGGSMVAAIDMLKRAGCREIRALTLVSAPEGIDAVLKAHPDVQIYTASIDQGLNENGYIMPGLGDAGDRIFGTTQKHAE
>NZ_CP020818.1|WP_003819788.1|1404644_1406081_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MRRAGKQGKWQQWLAGVMLALGAAGAAAQGLPSSLVAAWKATKLPDQSLSLVVQEINGPRLATLNAKEPRNPASVMKLVTTWAALSELGPSYAWRTEFLTEPGNRPDAHGVLRGPLYLRAGGDPQLLLQDLWALLRELRLRGVKQIGDLVVDRSIFGQVAIDPGAFDGASDRAYNASPDALMVGFGAQRLLFTPDAAARKWVPMIDPPLPGLRLEGAVEWSDVRCPGPPVVGTEPVVTQQGVSIRLSGKVAGSCGEFSLYRLALSQPEYASAVFRLLWRELGGTLKGQIRSGVVPPDAVVLASHDSPTLGEAIRTINKRSNNVMARTLLLTLGAERGRRPATVESSGVVARAVLGAQGLEMPELVIDNGSGLSREGRVSADSLASMLTVAWNSPLMPEFISSLAIAGVDGTVRRRLKGNGAQGMAHLKTGSLRDVRAVAGYVLGASGKRYVVVSMVNHENAAAVRSFDDALVAWLAEQ
>NZ_CP020818.1|WP_004568237.1|1403413_1404487_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MAAAFHRTYRVPTPLTLADFDYHLPPELIAQSPAAERGGSRLLHLDAASRLHDRRFPDLAGLLRPHDLLVFNDTRVIKARLTGQKATGGKVEVLVERITAPDRALAHVRASKSPGPGMRLRLAEAFEAEVLGREGELFDLRFPAPVLDLLDAHGATPLPPYITHAADATDERRYQTVYAREPGAVAAPTAGLHFDQPMLEQLAAQGVQRAFVTLHVGAGTFQPVRVQNLAEHIMHAEWYTVPEATVAAIARARAHGGRIVAVGTTSVRALESAAAQAQDGPLAAAQGDTRLFITPGYRYRVVDALLTNFHLPQSTLLMLVSALAGVEPIRRAYAHAVAERYRFFSYGDAMFIETPAP
>NZ_CP020818.1|WP_004568238.1|1402280_1403417_-|tRNA-guanosine(34)-transglycosylase-Tgt
MTGLQFELLATDGGARRGRLTLNHGVVETPIFMPVGTYGSVKAMLPHELEDIGAQIVLGNTFHLWLRPGTAIMEKHGGLHGFMQWDKPILTDSGGFQVFSLQGMRKITEEGVKFASPIDGARLFLTPEESMRIQRSLNSDIVMVFDECTPYEIDGRPASIDEAARSMRMSLRWARRSRDEFDRLGNPNALFGIVQGGMYETLRDESLAGLAEIGFHGYAIGGLSVGEPKEDMMRILAHVTPRLPAQAPRYLMGVGTPEDLVEGVARGVDMFDCVMPTRNARNGWLFTRYGDVKIRNARYRDDTRPLDPSCACHTCTHFSRAYLHHLQRANEITGARLNTLHNLHFYLAIMGEMREAIAAGRFEAWRAQFAADRARGVD
>NZ_CP020818.1|WP_003809416.1|1401791_1402136_-|preprotein-translocase-subunit-YajC
MSAIDTAGLVLAQAAPAEGNALMGMLPIVLMFVILYFLMIRPQMKRQKEHRNMVAALSKGDEVVTSGGMLGRVSKVTDSYITVEVSELADKPVEVVMQKTAVSAVLPKGTIKAL
>NZ_CP020818.1|WP_003809414.1|1399844_1401725_-|protein-translocase-subunit-SecD
MNRYPLWKYITVLVAVVIGLLYTLPNFYGESPAVQVSSAKATIKVDQATLEQVQQIIENAQLPADSVYYEQNGTLGTVRARFPSTDVQLQARDLIDRTLNTVAGDPHYTVALNLLPASPPWMRSLGWFEPKPMYLGLDLRGGVHFLLQVDMQGALTARYDSLVADVRSALRDQKAEVGAIERSGQSVVATFATAEQRDRARDVLRSRLPDLQFTETSDGGKLQLTGMLNPAAVTRVQDTALKQNINTLHNRINELGVAEPVIQQQGADRIIVQLPGVQDVAKAKELLGRTATLEIRMVDDSPAAQSALAAGSVPFGLERYTDRDGRPLLVRRQVVLTGENLQDAQPGRDGQTQQPAVHLTLDSKGARIFRDVTRDNIGKRMAILLFENGKGEVVTAPVIRSEIGGGQVQISGSMTAEEAADTALLLRAGALAAPMSIIEERTIGPSLGADNIAKGFYSTLYGFIAIAIFIIVYYHLFGIFSTIGLTVNVLLLLALLSMLQATLTLPGIAAIALTLGMAIDANVLINERIREELRNGATPQQAIHHGFERAWGTILDSNLTTLIVGLALLAFGSGPIRGFAVVHCLGIVTSMFSSVVGVRALANLWYGRKKKLSSISIGTVWKPKAN
>NZ_CP020818.1|WP_003809411.1|1398859_1399795_-|protein-translocase-subunit-SecF
MEFFRIHRTIPFMRHALVLNIISLVTFLAAVFFIITRGFHLSIEFTGGTVMEVSYAQTAQLDQVRTAIGTLGYTDFQVQNFGTSRDVMIRLPIAEGQTSATQSETVMGALKAADPAVELRRVEFVGPQIGQELLHNGLMALLVVVIGIMVYLGLRFEWKFAVAGVIANLHDVVIILGFFAFFQWEFSLAVLAGVLAVLGYSVNESVVIMDRIRENFRKYRKASVQEVINSAITQTISRTIITHGSTQMMVLAMLFFGGPTLHYFSLALTIGIWFGIYSSVFVAAALAMWMGVKREDLVKPVKKDGDEVEIA
>NZ_CP020818.1|WP_003819780.1|1397840_1398569_+|phosphatase-PAP2-family-protein
MTAEPITAFPPPKSGLPGQGLAGLLRRCLVPVLLLLGCAAWLDRPLTLWINRSVSPQVNTVFDYIGNLGDSGTYVALGLAAYILGLQGMLRGWAVPWGWTCEKIARAGMLLLATLTAGGLATWVLKNVVARARPEVLLDDGIYGMGRMFAGNPFNSFPSSHTQTAFAVAAVLGILAPRWRWPALALAALVAISRVINRDHYLSDVCAAALIAVVAAYAIKPYVLSPRYTWPLRAPWRWRKRG
>NZ_CP020818.1|WP_003819779.1|1396256_1397684_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MQETTVKRDGASPSDAGTPATAAQGLGKLYIRTFGCQMNEYDSDKMADVLRADQGLELTDNPEDADVILFNTCSVREKAQEKVFSDLGRVQHLKKQNPNLVIGVGGCVASQEGEAIVKRAPYVDVVFGPQTLHRLPDLIKRRRAQGVSQVDISFPEIEKFDALPPPRVDGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFDDVLLEVADLADQGVKEVTLLGQNVNAYRGAMGDSGKIADFAMLLEYVHEIPGIERIRYTTSHPKEMTQRMVDAYARLPKLVSFLHLPVQAGSDRVLAAMKRGYTALEFKSVVRRLRAARPSLTLSSDFIVGFPGETEEDFQKTMKLIEDVGFDTSFSFVYSRRPGTPAADLHDDTPQDVKLRRLQQLQALINQQAAAIAQGMIGTRQRVLVEGPSRRDPNELMGRTENNRIVNFPGVPRLIGHMVDVVVTHAHTNSLRGRVAGIERDTSGAE
>NZ_CP020818.1|WP_003809398.1|1395237_1396260_-|PhoH-family-protein
MSTSRSRARRTMPAIVNLDGDNIHLANLCGPLDENLRQLADGMGVKLARRGSRVTIEGEQAELAGRALRRFHEQATHRALSVDDIQLGLVEIGVGRPVEVQADPRELDQTLPPVDDESGGVVLRTRRTDLRPRTPRQRDYMNNILKHDITFGVGPAGTGKTWLAVACAIDAMERDTVQRLVLTRPAVEAGERLGFLPGDLAQKVDPYLRPLYDALYDLMGFERVQRLFEKQTIEIAPLAYMRGRTLNHAFVILDEAQNTTPEQMKMFLTRIGFGSKAVITGDPSQVDLPRGQQSGLAHAVQVLEEVQGIATTRFTSRDVVRHPLVARIVDAYDQAAANGD
>NZ_CP020818.1|WP_110129006.1|1407424_1410184_+|pertactin-autotransporter
MNMSLSRIVKAAPLRRTTLAMALGALGAAPAAHADWNNQSIVKTGERQHGIHIQGSDPGGVRTASGTTIKVSGRQAQGILLENPAAELQFRNGSVTSSGQLFDDGIRRFLGTVTVKAGKLVADHATLANVGDTWDDDGIALYVAGEQAQASIAASTLQGAGGVQVERGANVTVQRSAIVDGGLHIGALQSLQPEDLPPSRVVLRDTNVTAVPASGAPAAVSVLGASELTLDGGHITGGRAAGVAAMQGAVVHLQRATIRRGDAPAGGGVPGGAVPGGFDPGGFGPGGFGPVLDGWYGVDVSGSTVELAQSIVEAPELGAAIRVGRGARVTVSGGSLSAPHGNVIETGGARRFAPQAAPLSITLQAGAHAQGKALLYRVLPEPVKLTLTGGADAQGDIVATELPPIPGTSSGPLDVALASQARWTGATRAVDSLSIDNATWVMTDNSNVGALRLASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKVPPAPKPAPQPGPQPPQPPQPPQPQPQPQPQPEAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAGGAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW
>NZ_CP020818.1|WP_033459324.1|1410250_1411672_-|uroporphyrinogen-III-C-methyltransferase
MTLFPIFADLTGRRVLVVGGGAVAVRKTQALLQAGAEVVVGAPRLDPALAALAEQGGIARLDGGFEPAWLAGAWLVVAATDDRAVNAAVSEAARARRVFCNVVDDAELSSFQVPSVVDRSPLIVAISSSGVAPVLARRLRERIESLFDHSLGQLAALAARYRPRIRAARPDLGQRRRFYDWLLDGPVAARLRQQQPGLAEQELEQALRAPQAAPRGSVVLVGAGPGDPGLLTLKALRALNEADIILYDRLVSEGVLALARRDAERVPVGKLPGEDHDATQARIHALMLAQARAGRRVVRLKGGDAFIFGRGGEELEYLRAHDVPYEVVPGITAALACAAYAGIPLTHRDHAQSVRMVTAHCRADQDTLDWAGLARDQQTLAFYMGVGQLDYVTARLLEHGRAPATPFALIENGSRPEQRVVTGTLADLPEIARRRGVRPPALLVIGEVAALADTLQWFGQHQRGLPGPQALAA
>NZ_CP020818.1|WP_003809431.1|1411936_1412653_+|hypothetical-protein
MMVRFFVSIGVLAWAGAAQAGVCDAKFMHDGGQVQLTGSGNIGLGADLGFTEVSKTNGDNCRARVQGMATFSYAGLPPGKSRLDYLMTVKNGQATFVKYAEAGEQPRSEGQFDLRMLGLFAYDKISGEGQRLPGASYRLRIGKEAPVGGQPTTVVRIGEKTVGARQDLSTALGRHACWPITYPRSSEPTMATFKGLTLPIPGMDTTVTDWYCPSVNLVMRQDIDQAGIKSSVEITQLK
>NZ_CP020818.1|WP_003809432.1|1412737_1413055_+|DUF883-domain-containing-protein
MAARRSDEATKEKLIDSVKTSLNDAETLLREAASTTGDKATELRERALASVRRTREALYDAQDAVLERGRRAARATDDYVHDNPWQAISIAGVTGLLLGLLISRR
>NZ_CP020818.1|WP_003819794.1|1413095_1413509_+|phage-holin-family-protein
MGLRRSVFGVAASLVGLTRTRLELLALEAAGEKIRLIKLLGMAFGALLFLTLAVLVFTITIAVAFWPTESRYAALGWLAGGYGVIGLVLFFLVRRDLVDGPVPFAATLEELGRDTDMLERVRDAQRASDGQRNAEDD
>NZ_CP020818.1|WP_003819796.1|1413510_1413870_+|hypothetical-protein
MARHSASVDRMVRLELLRARAALEREALAQGIVEAGRTLTPSNMVKSIWPSLGKANTSRLFWQAFALVRRYPFVSSTLSAMVMGRGARRSRLLKLAGVALVGWQAYRLWQSAREERQAD
>NZ_CP020818.1|WP_033459982.1|1413912_1415457_-|UbiD-family-decarboxylase
MKYRDLRDFLAQLERQGELKRITAPVSTRLEMTEIADRVLRAGGPALLFENARHNDAPADMPVLANLFGTPRRVAWGMGADDVGALRETGELLASLREPEAPKGLRDALAKVSMLKAALWDMSPKTVRSAACQEIVWEGADVDLGRLPIQTCWPGDVAPLLAWGLVITRGPNARRQNLGIYRQQPLGPNKLIMRWLSHRGGALDFRDHAQAHPGKPFPIAVALGADPATILGAVTPVPDTLSEYQFAGLLRGSRTEVVKALGSDLSVPASAEIVLEGHLLPADDPRAVAAVAPEGANPPPATGYEMALEGPYGDHTGYYNEQDWFPVFTVDRITMRRNPIYHSTYTGKPPDEPAVLGVALNEVFVPLLRRQLPEIVDFYLPPEGCSYRLAVVSIRKQYAGHAKRVMFGLWSVLRQFMYTKFIVVVDEDIDPRDWTEVVWAMTTRMDPVRDTVLVENTPIDYLDFASPVSGLGGKMGLDATNKWPGETSREWGTPIHMDEAVKRRVDAMWDTLGL
>NZ_CP020818.1|WP_003809436.1|1415540_1416371_+|lytic-transglycosylase-domain-containing-protein
MPDASVAGLFRQLAQGVHHHLAEWLRISSVYLGIAVIVTVSMGFALPGLRDQALQVHKALLTALAPTSMPSAELEPGAEAGADASSAVVMAIPSAPASNATGFLGPLRSDTPPAPPNRPSAASSAQVEALRNYISRKYKVAYDATAVLVNTVYKVGREKQLDPLLLLAVIAIESRYNPFAESPVGAQGLMQVMTRVHQDKFDAIAHVGKGNPLDPVANIHVGSTILKDCINRRGSLNGGLACYVGATGPDDGGYGAKVLAERRRLALASGIALARD
>NZ_CP020818.1|WP_003819799.1|1416405_1417560_-|pyridoxal-phosphate-dependent-aminotransferase
MPRLATRTNDFLTFQVVELFKEAQALQAAGRDIISLGIGEPDFTAPPQVVEALERAARAGLSGYSAPAGLSALREAIAAFYESEFGARVDPARIIVTAGASGALALACAALVNPGAQVLMPDPSYPANSNFVLAAGGQPRLIPSTAAKRFQLSAQDVRDHWNDATQGVLIASPSNPTGTSIAHDELAELLAAVRERQGFSIVDEIYLGLSYESQPRSALLLDDDIIVINSFSKYFHMTGWRLGWMIVPESMAAKVEKMAASLAICAPTLAQHAALACFTPDALKIFEHRREAFKQRRDYLLPEFERLGIPVPVRPDGAFYIYADIAALGTTSMAFSHRLLHEGGVAAVPGLDFGPAHGERTMRFSYATGLDRLQEAVARIEKLL
>NZ_CP020818.1|WP_080704246.1|1417734_1418475_+|hypothetical-protein
MLRARSDAEVRRARALCQEYGVSLGLPGARPAGRPVLQIDPRGLRALAPEGGAWRAGPGCLAGELAAAGLGQFAEVAPTCTLADWLADSRGWPTGETGASGVLEASVLLADGTAEALGPFGAADVRPLRSATVQRLVPALFQLAGGQDAAACLAQPAWPARYRLDALQPREPAGVNLAHLLLGHDGALAWVESVLLAPAAAPPPAASGSAPAEAARLDARVRALFDPDGVLAARAGSGAVGAKGRE

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Crispr_ID: NZ_CP020818_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_4

1463604-1463702

Orphan

Consensus_repeat	Method
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020818_4

>merge|NZ_CP020818|4|1463604-1463702|CRISPRCasFinder
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCACTTCGCGGATTGGGACAGGCACGCGGGGAAGTTTGCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC

>NZ_CP020818|4|4|1463604-1463702|CRISPRCasFinder
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC	TTCGCGGATTGGGACAGGCACGCGGGGAAGTTT
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_033454520.1\|1473717_1476378_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274682
NZ_CP020818.1\|WP_003809557.1\|1468845_1469334_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NZ_CP020818.1\|WP_033448647.1\|1465122_1466817_-\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|181285
NZ_CP020818.1\|WP_003819849.1\|1466974_1467862_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
NZ_CP020818.1\|WP_003809532.1\|1455950_1456973_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270410
NZ_CP020818.1\|WP_003809539.1\|1459025_1459817_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270248
NZ_CP020818.1\|WP_003809561.1\|1470104_1470506_+\|ribbon-helix-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|226771
NZ_CP020818.1\|WP_003819847.1\|1463849_1465106_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
NZ_CP020818.1\|WP_003809565.1\|1472311_1473514_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP020818.1\|WP_033465325.1\|1470512_1471625_-\|D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|236952
NZ_CP020818.1\|WP_003819850.1\|1467899_1468832_+\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP020818.1\|WP_003809536.1\|1458093_1458999_+\|arginase	unknown	unknown	gnl\|CDD\|212538
NZ_CP020818.1\|WP_042997587.1\|1457064_1457901_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP020818.1\|WP_010930417.1\|1469453_1470032_+\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153243
NZ_CP020818.1\|WP_003819841.1\|1460553_1461306_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP020818.1\|WP_003809541.1\|1459839_1460532_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP020818.1\|WP_003819837.1\|1453566_1454757_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NZ_CP020818.1\|WP_080605910.1\|1454761_1455814_+\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
NZ_CP020818.1\|WP_003809544.1\|1461434_1462994_+\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236063
NZ_CP020818.1\|WP_003819845.1\|1463025_1463571_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239538

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_033454520.1\|1473717_1476378_+\|hypothetical-protein	gnl\|CDD\|274682	TIGR03623, TIGR03623, probable DNA repair protein. Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.	0
NZ_CP020818.1\|WP_003809557.1\|1468845_1469334_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	9.78705e-67
NZ_CP020818.1\|WP_033448647.1\|1465122_1466817_-\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|181285	PRK08199, PRK08199, thiamine pyrophosphate protein; Validated.	0
NZ_CP020818.1\|WP_003819849.1\|1466974_1467862_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	1.14336e-66
NZ_CP020818.1\|WP_003809532.1\|1455950_1456973_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270410	cd13692, PBP2_BztA, Substrate bindng domain of ABC glutamate/glutamine/aspartate/asparagine transporter; the type 2 periplasmic binding protein fold. BztA is the periplamic-binding protein component of ABC transporter specific for carboxylic amino acids, glutamine and asparagine. The BZtA domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.2809e-119
NZ_CP020818.1\|WP_003809539.1\|1459025_1459817_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270248	cd13530, PBP2_peptides_like, Peptide-binding protein and related homologs; type 2 periplasmic binding protein fold. This domain is found in solute binding proteins that serve as initial receptors in the ABC transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1, but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction.	9.69108e-62
NZ_CP020818.1\|WP_003809561.1\|1470104_1470506_+\|ribbon-helix-helix-domain-containing-protein	gnl\|CDD\|226771	COG4321, COG4321, Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only].	8.35442e-42
NZ_CP020818.1\|WP_003819847.1\|1463849_1465106_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
NZ_CP020818.1\|WP_003809565.1\|1472311_1473514_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.91228e-73
NZ_CP020818.1\|WP_033465325.1\|1470512_1471625_-\|D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|236952	PRK11669, pbpG, D-alanyl-D-alanine endopeptidase; Provisional.	1.02042e-102
NZ_CP020818.1\|WP_003819850.1\|1467899_1468832_+\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	1.37589e-163
NZ_CP020818.1\|WP_003809536.1\|1458093_1458999_+\|arginase	gnl\|CDD\|212538	cd11592, Agmatinase_PAH, Agmatinase-like family includes proclavaminic acid amidinohydrolase. This agmatinase subfamily contains bacterial and fungal/metazoan enzymes, including proclavaminic acid amidinohydrolase (PAH, EC 3.5.3.22) and Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA). PAH hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Clavulanic acid is an effective inhibitor of beta-lactamases and is used in combination with amoxicillin to prevent the beta-lactam rings of the antibiotic from hydrolysis and, thus keeping the antibiotic biologically active. GbuA hydrolyzes 4-guanidinobutyrate (4-GB) into 4-aminobutyrate and urea while GpuA hydrolyzes 3-guanidinopropionate (3-GP) into beta-alanine and urea. Mutation studies show that significant variations in two active site loops in these two enzymes may be important for substrate specificity. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	1.51723e-115
NZ_CP020818.1\|WP_042997587.1\|1457064_1457901_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.54248e-66
NZ_CP020818.1\|WP_010930417.1\|1469453_1470032_+\|DJ-1/PfpI-family-protein	gnl\|CDD\|153243	cd03169, GATase1_PfpI_1, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	1.34539e-109
NZ_CP020818.1\|WP_003819841.1\|1460553_1461306_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.23529e-151
NZ_CP020818.1\|WP_003809541.1\|1459839_1460532_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.52172e-80
NZ_CP020818.1\|WP_003819837.1\|1453566_1454757_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	0
NZ_CP020818.1\|WP_080605910.1\|1454761_1455814_+\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	6.96555e-71
NZ_CP020818.1\|WP_003809544.1\|1461434_1462994_+\|acetolactate-synthase-large-subunit	gnl\|CDD\|236063	PRK07586, PRK07586, acetolactate synthase large subunit.	0
NZ_CP020818.1\|WP_003819845.1\|1463025_1463571_+\|MaoC-family-dehydratase	gnl\|CDD\|239538	cd03454, YdeM, YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	1.06798e-70

>NZ_CP020818.1|WP_003819845.1|1463025_1463571_+|MaoC-family-dehydratase
MPPRNTRAARLVYPAALARLGSNGLPAAFQQGRSMKFADLRAGMVITGGPLQVTEAEILEFARKFDPQWFHTDVQRAAEGRWGGLIASGWHTCALAMRMAVDAILHDSESFGSPGLGEVSWRVPVRPGDTLTLHARVQGARVSASRNDLGIVNWAWVVDNQHGETVLELDATSLFDLSGDS
>NZ_CP020818.1|WP_003809544.1|1461434_1462994_+|acetolactate-synthase-large-subunit
MNGADSLCDTLLANDIDVCFANPGTSEMHFVAALDRKPRMRCVLGLFEGVVTGAADGYARMADKPAATLLHLGPGLGNGLANLHNAKRARTPMVNVVGDHATYHVQYDAPLTSDVEAVAQPMSHWVGRIRDAASVAAQTSEAIQVARQEPGNVSTLILPADAAWTDLPDDTPAPQPVRQAPQAQADAQAIRAAAQAIRSGQATTLLLGGAALRGRALAAAGRIAHATGVRLAAETSSRRTERGANRPPVVRLPYPVDLAVAFLKDVRHLVLVGSRSPVAFFAYPGKPSLLAPQECDQIVLAEPEQDLHHALEWLADELGIPADAPQTRPAALTEAVPAEGRLTSAAVNRVAAALLPDNAIVCDESITQGREFGIYSVHSAPHDWLQLTGGAIGIGLPLATGAAVACPDRKVVLLQADGSGMYTVQALWTQARERLDCLTIIYANRTYATLHGEMKNVGVIQPGENAKRMLDLVDPHIDWVQVSQGLGVEAVRVDTVEGFTQAMRAALARKGPFLIEAVI
>NZ_CP020818.1|WP_003819841.1|1460553_1461306_+|amino-acid-ABC-transporter-ATP-binding-protein
MDACNQPAPVITLRGVSKWYGDFQVLRDLDLDVYQGERVILCGPSGSGKSTTIRLLNRLEEHEKGEIVVNGITLDGELRNIERIRADVGMVFQHFNLFPHLTVLENCTLAPMRVKGLDEGEAARRAMQFLERVRIAQLADKYPGQLSGGQKQRVAIARALCMQPRIMLFDEPTSALDPEMVKEVLDTMVELARDGMTMICVTHEMGFAREVGDRVVFMDGGSIVESDTPERFFSAPRSSRAQAFLGQILG
>NZ_CP020818.1|WP_003809541.1|1459839_1460532_+|amino-acid-ABC-transporter-permease
MNLETLRMYLTPLAEGTMWTLALFFCSAVLAVALGLLVCLCRLSKSRVLSRGARLYIDIIRGTPLLLQLFYIYYGMPELGVVINAFVAGVLGLTLNFGAYLAELFRSGIQSVDSGQYEAARALGLNKVDRLRRVVLPQAVRTVFPALGNYALVLIKETSLVAVISVYELMRAGEMLAGATFQALTVYTMVGAIYFAMCSVLAHLFRRSEKRLTVPGYWSGAGENHDISKA
>NZ_CP020818.1|WP_003809539.1|1459025_1459817_+|amino-acid-ABC-transporter-substrate-binding-protein
MKIKAALGILATVGMLAHAGSAAARTLDEVRAAKSANVVTTASAPPHGFKNPASNQLEGIMVDVGAAVAKHLGVAMNLKDVPFSGLIPTLTSGRADVMSAPLFVTPERAKVIDFSAPVYEWGEGLVLREQNPDDIKRFEDLQGRRIGVLVDSVQFNMIKDMPDTKVSTYQDYSTLLADVRAGRIELGIIDPPSIIYQIRTKKIPGVKLATQYQPQKKWHVGLAVQKDNKALLDAVNAALAEMKRNGELAEIGRKWGVADLISK
>NZ_CP020818.1|WP_003809536.1|1458093_1458999_+|arginase
MGVPARRPAGEAALACVLGIPFDCGTHPFRVGARQGPDAIREQSRLLRPYDLARRAGVDNPVEFLRLLDLGNVACVPGDPQASYPAIEQAVAQVLQAGAIPITMGGDGAVTLPQLRAVARRWPGVAVLHFDSHTDTYPIAGYNTATTFTRAAEEGLIDLSHSFHVGTRGNSFMGGVIEYGREVGYTVIPYDDFDRDQAGTLARLRGQLGDRPVYLCFDMDIFDPSCAPGVCTPEWGGLSPKEGLNLLRALSGLNFVAFDVNTVSPPQDVGGATAFLAASVMQEFCALAAAAVQAYPQGRPD
>NZ_CP020818.1|WP_042997587.1|1457064_1457901_+|IclR-family-transcriptional-regulator
MTTVAPEDSPLFVAALARGLTLLAAFSEGRPAMTLPELADATGLTKSAAQRFAHTLWTLGYLRKNPDSKKFSLSPQSLQLGMQYAQTSPLVLGGNPFLHSLNRTSQETCSLAEPDGLDMVYVARFATHKQMFVHMPVGMRIPMYCAAAGRAVLARLEPDRARRLLQQSPRAARTATTLTDLDALMAELAFTREHGYARSNGEYYPGDITISAAVLDNAGTPAGSVNISVPSSRWSFEEAQAVFGPQVLETAHAISASRTLGVLPPFYRMAPPSALNSD
>NZ_CP020818.1|WP_003809532.1|1455950_1456973_+|amino-acid-ABC-transporter-substrate-binding-protein
MKRHIAMAAGALALALGAQAAHAGPTLDAVKKKGFVQCGLTDGVAGFSATNSKGEWEGMDVDICRAVAAAVFGDAGKFKGTALSTQQRFTALQSGEVDVLLRTVTLTQTRDTSLGLAAVAASFYDGQGVLVRKALGVKSAKELDEATICVQPGTTTELNLADWFRANGIKFTPVVIDKVTEVVRAFESGRCDAFTDDASQLAAVRATQVAKPDDFEILPERFSKEPLGPMVRQGDENWLGIVRWTLFALMEAEEYGITQQNVDEMLKSKNPNVLRILGVTPGAGKNMGLDEKWAYNAIKAVGNYSQIFERNVGKDSRLGLQRGVNALWSQGGAMYPWPIR
>NZ_CP020818.1|WP_080605910.1|1454761_1455814_+|threonylcarbamoyl-AMP-synthase
MIPAAMNAADPAVAHAAACLLAGELAAFPTETVYGLGADAENPQAVARIYAAKGRPSNHPVIVHIAPEGDVDYWASDVPAAARQLIQAFWPGPLTLILKRAPHIGAAVSGGQDSIGIRCPSHPVAQALLRAFAAGKPNGQGGVAAPSANTFGHVSPTRAEHVRAEFPREVAAGMPVLDGGDAEVGIESTIIDLSRLDQGVGPVLLRPGHISAAQVAAVLGMPVARPDAAAPRASGTLKAHYAPRTPLELLDAAQLPRALAAAPAGVRQAVVALAPAPAGLSADVHWRMAPADPARYAQALYALLRELDRQGYARILVEQPPRSGDWDAVNDRIGRAAAAFSLDTTDLPGT
>NZ_CP020818.1|WP_003819837.1|1453566_1454757_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MTQSSTFDPIAPGDWLGLLGGGQLGRMFCHAAQSLGYKVAVLDPADECPAGMVADLHIQAAYDDADGLARLAGRCRAVTTEFENVPADSLRALAARCRVSPAADAVAVVQDRIAEKTFIAGQGIEVAPHAAIRARDDLLAAPQALFPGILKVARLGYDGKGQARIASREEALAAFDEFGGVPCVLEALLPLDYEISVVIARGFDGASMVFPIARNVHRDGILAVSSVTPGAADASHAARQVQATQAAQAIAQGLGYHGVLCVEFFVLGDGRLVVNEIAPRPHNSGHYTIDACVTSQFEQQARVMAGLPLGSADLLAPAVMLNILGDAWFEPGAHAPREPDWSAALAVPSAKLHLYGKREARRGRKMGHVTIVAATPEQARDDAARVARALGMAAPF
>NZ_CP020818.1|WP_003819847.1|1463849_1465106_-|acyl-CoA-dehydrogenase
MPRPHIHDPDLSFSYLHWSTRMSSTPSFHWQDPLLLDQQLTEEERMVRDAAVAYSQDKLAPRVLEAFRHEKTDPAIFAEMGELGLLGATIPTEYGGAGLNYVCYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGSEAQKRKYLPKLAAGEWIGCFGLTEPNHGSDPGGMETRATKTPDGYKLTGNKMWITNSPIADVFVVWAKCVGGDFDGKIRGFILEKGMKGLSAPAIHGKVGLRASITGEIVMDEVEVSEEQMMPGVSGLKGPFTCLNSARYGIAWGALGAAEACWHTARQYTMDRKQFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY
>NZ_CP020818.1|WP_033448647.1|1465122_1466817_-|thiamine-pyrophosphate-binding-protein
MTTANHSTPASRLGGHILVDQLAAHGVKHVFCVPGESYLAVLDGLHDASIDVTVCRQEGGAAMMADAHGKLTGEPGICMVTRGPGASNALAGVHIAKQDSTPMILFVGQIERGMREREAFQEMDYRAVFGTQAKWVTEIDQVERIPELISRAFHVATSGRPGPVVIALPEDVLVETASVPDAPRYEVIDAAPAAGQMDQLAQMLAQARAPVAILGGSRWNAQAVQQFADFAQRHALPTAVSFRRQMLFPADHPCFIGDVGLGINPALLKRIEQADLVLMVGGRMSENPSQAYTLLDIPVPRQKLVHVHPDSAELGRVYRANLAINTSPAAFCAALAQANGPSQPAWADDTQAMRASYLQWSDPAAIRTPGALQLGEVMAFLEKTLPADAIMANGAGNYATWLHRFHRYTRYGTQLAPTSGSMGYGLPAAVGAKRIWPQKTVVCFAGDGCFLMHGQEFATAVQYDLPIVVVLIDNGMYGTIRMHQEKHYPGRISATSLKNPDFAEYARAFGGHGERVETTEQFAPAFERALASGKPAILHCLIDPETITPSTTLEKIRAAALKAQ
>NZ_CP020818.1|WP_003819849.1|1466974_1467862_+|LysR-family-transcriptional-regulator
MRNGIPNLSALQAFEATARLGSFSRAAEELSLTHSAVYRQVASLEDRLGVQLFTRVRRRIVLTDHGAEYAGRIRHHLDQIEKDTFGLVSRTGMGRSIHIAVVPTLATTWLIPRLADFQRVQPDITVSLSVRTLPFQFKDQPFDGALYHGDGIWPGTQGVLLFPERELVPVCAPELAERASGRDDGALGGMMHLHLYSRPDAWRQWYAANQYAYGPQAAGGPRYDLFTMMLAAVQAGLGVGLMPRFLVQDALDAGTLVMPVPQALSVSQGYYFGYPQRSERSGALKAFEVWLKSAV
>NZ_CP020818.1|WP_003819850.1|1467899_1468832_+|site-specific-tyrosine-recombinase-XerD
MSSSAPLASQADLDAFIDAVWLEDGLAANTLAAYRRDLSAFAQWLENPACHPGLATGASLREAGKGDIEAWFAARHAESRATTANRRLAALRRFYAWALRERLTPSDPCLTLVTAKQPPRLPKTLSEAQVDALLQAPDLDTARGLRDRAMLETLYATGLRVSELVSVKALDVSLNEGVVRVVMGKGGKDRLVPLGAEAAHWIERYAGSARPELLGARVADALFVTARAEPMSRQAFWQLVKKYALAADIHAPLSPHVLRHAFATHLLNHGADLRVVQMLLGHADISTTQIYTHVARERLKALHAAHHPRA
>NZ_CP020818.1|WP_003809557.1|1468845_1469334_+|Cys-tRNA(Pro)-deacylase
MSKNRHVSETPATQLLRQRKVAFTEHTYDYVDHGGAGEAARQLGLDPHAVVKTLIMEDEGGHPLVVLMHGDREVSTKNLARQAGLKKVAPCQPEVAQRHSGYQVGGTSPFGTRKRMPVWVEASVLDFPQIYVNGGRRGYLVGIAPQALVDLLGARAVQVALP
>NZ_CP020818.1|WP_010930417.1|1469453_1470032_+|DJ-1/PfpI-family-protein
MSKKLLMLVGDYAEDYETMVPFQTLLAVGHTVHAVCPDKKAGDTVATAIHDFEGAQTYSEKRGHNFTLNHDFAKVEPQHYDGLVIPGGRAPEYLRLDERVLDIVRHFDQAGKPIAAVCHGAQLLAAAGILQGRTCSAYPACAPEVRLAGGTYAEIGIDQAHTDGNLVTAPAWPAHPAWLAQFLAVLGTRISH
>NZ_CP020818.1|WP_003809561.1|1470104_1470506_+|ribbon-helix-helix-domain-containing-protein
MSCTNRVPGILMCEIFIRANQRSYSVQARSLRLHGVATSVRLEQLFWDVLEEIAARDGMRVTQLIERLYDELVQYRGEAANFTSFLRVCCLRYQVLQAEGRIPADATVPIRSLDAQAVLRGLPANLYDSRPLG
>NZ_CP020818.1|WP_033465325.1|1470512_1471625_-|D-alanyl-D-alanine-endopeptidase
MAFHWTRAVARALAPLALAIGALLPYAAHAAKADPCRTNAKSAACKSQQAKKASAKKAPAKTTSSKKSASTAKKKSASSKKTASAKKGSTRKSTIRARTRTARASAAATAAMPPAAASPAAEAAALRSSTAYVQDLETSTVLFAKNENVVRPIASISKLMTALVVVDANLPMDEMIEITDDDVDTLKHTTSRLRVGTVLSRGDMLHLALMSSENRAAHALGRNYPGGMPAFVAAMNAKARSLGMLNTRFVEPTGLSSENVSSPRDLARMLRAASQRPLIHRYSTDTEYEVEINNRTQTFRNTNLLVRKPDWDIKVSKTGFINEAGECLVMLARINGRDMAIVLLDSQGKLSRIGDAVRIRRIVQNDVAML
>NZ_CP020818.1|WP_003809565.1|1472311_1473514_+|MFS-transporter
MSTSEKPSLRILFIGTGVVLLAMGVRATFGLFMQPMGLAHGWGREVFSMAFALQNLVWGAACIGMGILADRYGSGRTIVLGAVLYALGMIGTRFATDEATLYLTAGVLVGLGQAGTTFPVILPVVARSVPAAYRSTAMGIASAGGSLGQFLVVPAGQQLITGLDWPGALWVLSLLVAVGAPLAYFLRGKPGVHGGVQQSLGAAVRQAMAHPSFHFLSWSYFVCGFHTAFITLHLPAYVVDAGMKASHGATAIALIGLCNVIGSFYAGKLGGVYSKRLLLAAIYGLRAFGMLLLLAVPLTPLVLYVFAGWMGLFWLGTVPLTQGLIGQIYGLRYAATLSGIAFLGHQVGSFIGVWMGGAVYARTGNYDLVWWTGVALAVVAALLCLPVREQPLAQPAAARA
>NZ_CP020818.1|WP_033454520.1|1473717_1476378_+|hypothetical-protein
MSDDFRTDFPSCTLRDLGELPAIDTLVLTVNNRLSRRLTLDLAAQLRSERQVSELPRIMPLSAWLADCAAELAFDERYEVPAYRLSSFATQLVWREAIRLEEADRALLDADQAARLALDADLLVDEWQAHVPAGAETDEYRGFSRWRARYRAMLGELDAEDANQGYERVLEALRQGALRAPRHVALAGFVDISPRFARLLRALADGGADVVAWRDAVREPAWPQRFEAADRGAEWRAAARWAADRLRADPRGRYAIVSPQLEAEAPFARRVLGQALAGQDAPLPFNVAVGRALDEWPAVRAALAWLALLAEVAARGAGEPALFGAALLAGHCAGDLQEGPRHAALDARWRRQALAHVGPADWQRGLEECPRLAEGWSQAMEIWQAGQRSDTCDAWAPRFKAALTALGFPGERALDSVAYQVMGALGDLLAEFTALAPAAGRLDGRAAVRLLASAARAGSFQPQRDPSARLDVLGLLEAEGGAWDGIWVLGLTDDVLPASPKPNPLLPLAVLRQVGAPRATPEREREWAEGMFMALRRCAPEMIASHAAMDGERELRPSPLIARAAPADWQPGADAQAAALEQEILDDSQGPPLQAERQSRGGLDVLDTQARNPLWAFVRHRLGGRAMAPYADAATVSVRGQFLHRALELVWRMLPDQEALHAAMAEGRLAALVEQAIGEAARTELAGYPAALRELECARAAAVLANWFDSEAQRQPFEVAQIEQEHSWQRGALALKVRLDRMDRLADGRALIVDYKTGAAPGRPESDWARARPVNLQLPFYASVLADGADTEVAGLMLAQIHARQVSAQGLAADDLGIEGVTPVEQSKAFEGQPWPRILQRWRAAVEMLADEYANGYAANVALRQDDLKFCDAMPFLRLHLDDEDA

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Crispr_ID: NZ_CP020818_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_5

2807102-2807212

Orphan

Consensus_repeat	Method
CCGCACGGGCGCCTGTCCCCGCAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020818_5

>merge|NZ_CP020818|5|2807102-2807212|CRISPRCasFinder
CCACACGGGCGCCTGCCGCATCCCGCCCCCGCCGCACGGGCGCCTGTCCCCGCAGGGGGACTGGCGCCTGCCCCGTCCCGCCCGCACCGCACGGGCGCCTGTCCCCGCAGG

>NZ_CP020818|5|5|2807102-2807212|CRISPRCasFinder
CCACACGGGCGCCTGCCGCATCCCG	CCCCCGCCGCACGGGCGCCTGTCCCCGCAGGGGGACTGGCGCCTGCCCCGTCCCGCCCGCA
CCGCACGGGCGCCTGTCCCCGCAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_003811927.1\|2803916_2804792_-\|flagellar-motor-stator-protein-MotA	unknown	unknown	gnl\|CDD\|181655
NZ_CP020818.1\|WP_003811933.1\|2806266_2807004_+\|RNA-polymerase-sigma-factor-FliA	unknown	unknown	gnl\|CDD\|235901
NZ_CP020818.1\|WP_003811931.1\|2805507_2805831_-\|flagellar-transcriptional-regulator-FlhD	unknown	unknown	gnl\|CDD\|179497
NZ_CP020818.1\|WP_003811929.1\|2804912_2805473_-\|flagellar-transcriptional-regulator-FlhC	unknown	unknown	gnl\|CDD\|237181
NZ_CP020818.1\|WP_004567204.1\|2807403_2808579_+\|flagellin-FliC	unknown	unknown	gnl\|CDD\|235867
NZ_CP020818.1\|WP_003811919.1\|2799962_2800463_-\|chemotaxis-protein-CheW	unknown	unknown	gnl\|CDD\|182587
NZ_CP020818.1\|WP_033476086.1\|2821034_2822018_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP020818.1\|WP_033459377.1\|2800477_2802535_-\|chemotaxis-protein-CheA	unknown	unknown	gnl\|CDD\|236712
NZ_CP020818.1\|WP_004567201.1\|2797313_2798174_-\|chemotaxis-protein-methyltransferase	unknown	unknown	gnl\|CDD\|236725
NZ_CP020818.1\|WP_110129059.1\|2798182_2799889_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|185008
NZ_CP020818.1\|WP_110129060.1\|2808801_2810592_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|180579
NZ_CP020818.1\|WP_003817154.1\|2802956_2803904_-\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|236365
NZ_CP020818.1\|WP_003817149.1\|2812293_2814999_-\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NZ_CP020818.1\|WP_003811922.1\|2802561_2802942_-\|response-regulator	unknown	unknown	gnl\|CDD\|381110
NZ_CP020818.1\|WP_003817147.1\|2815291_2817046_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226654
NZ_CP020818.1\|WP_003817144.1\|2822141_2822792_+\|SCO-family-protein	unknown	unknown	gnl\|CDD\|239266
NZ_CP020818.1\|WP_033459366.1\|2810604_2812281_-\|dihydrolipoyllysine-residue-acetyltransferase	unknown	unknown	gnl\|CDD\|237000
NZ_CP020818.1\|WP_003811946.1\|2817042_2817669_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|226932
NZ_CP020818.1\|WP_003811948.1\|2817665_2818517_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	unknown	unknown	gnl\|CDD\|184559
NZ_CP020818.1\|WP_080699493.1\|2818592_2820707_+\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_003811927.1\|2803916_2804792_-\|flagellar-motor-stator-protein-MotA	gnl\|CDD\|181655	PRK09110, PRK09110, flagellar motor stator protein MotA.	1.34135e-169
NZ_CP020818.1\|WP_003811933.1\|2806266_2807004_+\|RNA-polymerase-sigma-factor-FliA	gnl\|CDD\|235901	PRK06986, fliA, flagellar biosynthesis sigma factor; Validated.	2.14427e-104
NZ_CP020818.1\|WP_003811931.1\|2805507_2805831_-\|flagellar-transcriptional-regulator-FlhD	gnl\|CDD\|179497	PRK02909, PRK02909, flagellar transcriptional regulator FlhD.	9.42998e-49
NZ_CP020818.1\|WP_003811929.1\|2804912_2805473_-\|flagellar-transcriptional-regulator-FlhC	gnl\|CDD\|237181	PRK12722, PRK12722, flagellar transcriptional regulator FlhC.	6.36062e-127
NZ_CP020818.1\|WP_004567204.1\|2807403_2808579_+\|flagellin-FliC	gnl\|CDD\|235867	PRK06819, PRK06819, FliC/FljB family flagellin.	3.97597e-159
NZ_CP020818.1\|WP_003811919.1\|2799962_2800463_-\|chemotaxis-protein-CheW	gnl\|CDD\|182587	PRK10612, PRK10612, chemotaxis protein CheW.	9.03634e-84
NZ_CP020818.1\|WP_033476086.1\|2821034_2822018_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.66778e-23
NZ_CP020818.1\|WP_033459377.1\|2800477_2802535_-\|chemotaxis-protein-CheA	gnl\|CDD\|236712	PRK10547, PRK10547, chemotaxis protein CheA; Provisional.	0
NZ_CP020818.1\|WP_004567201.1\|2797313_2798174_-\|chemotaxis-protein-methyltransferase	gnl\|CDD\|236725	PRK10611, PRK10611, protein-glutamate O-methyltransferase CheR.	1.09779e-146
NZ_CP020818.1\|WP_110129059.1\|2798182_2799889_-\|HAMP-domain-containing-protein	gnl\|CDD\|185008	PRK15048, PRK15048, methyl-accepting chemotaxis protein II; Provisional.	3.15355e-130
NZ_CP020818.1\|WP_110129060.1\|2808801_2810592_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|180579	PRK06467, PRK06467, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_CP020818.1\|WP_003817154.1\|2802956_2803904_-\|flagellar-motor-protein-MotB	gnl\|CDD\|236365	PRK09041, motB, motility protein MotB.	0
NZ_CP020818.1\|WP_003817149.1\|2812293_2814999_-\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NZ_CP020818.1\|WP_003811922.1\|2802561_2802942_-\|response-regulator	gnl\|CDD\|381110	cd17562, REC_CheY4-like, phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins. CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.58059e-44
NZ_CP020818.1\|WP_003817147.1\|2815291_2817046_+\|PAS-domain-S-box-protein	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	1.82813e-46
NZ_CP020818.1\|WP_003817144.1\|2822141_2822792_+\|SCO-family-protein	gnl\|CDD\|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	1.84299e-54
NZ_CP020818.1\|WP_033459366.1\|2810604_2812281_-\|dihydrolipoyllysine-residue-acetyltransferase	gnl\|CDD\|237000	PRK11855, PRK11855, dihydrolipoamide acetyltransferase; Reviewed.	0
NZ_CP020818.1\|WP_003811946.1\|2817042_2817669_+\|response-regulator-transcription-factor	gnl\|CDD\|226932	COG4566, TtrR, Response regulator [Signal transduction mechanisms].	1.17862e-90
NZ_CP020818.1\|WP_003811948.1\|2817665_2818517_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	gnl\|CDD\|184559	PRK14189, PRK14189, bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase.	0
NZ_CP020818.1\|WP_080699493.1\|2818592_2820707_+\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0

>NZ_CP020818.1|WP_003811933.1|2806266_2807004_+|RNA-polymerase-sigma-factor-FliA
MPNPEDSLVQYAPLVRKLALQLLARLPSSVQLDDLVQAGMIGLLDAVRRYQESPDAQFETYATARIRGAMLDELRSQDWLPRSVRSKSRRIETAIQRKEQELMRAPSEGEIAEELGVPLAEYQGMLADAQGVQILHYEDFNTDGDSDSPWAESSAEHADPLDALLAGDLRRALIDAIDGLPEREKLLLSLCYEQGLNLKEIGAVLNVTEARVCQLRAQATARIRARLKEQAWARLPTAHHLAQVV
>NZ_CP020818.1|WP_003811931.1|2805507_2805831_-|flagellar-transcriptional-regulator-FlhD
MKTADSSLLADIREVNLSYLLLAQRMLRDDYAASMFRLGFSNEVADILMRLSPAQLVKLASSSSLLCRFRFDDYSLLSALTQDVLGGALQQAHATILLARQPVEELA
>NZ_CP020818.1|WP_003811929.1|2804912_2805473_-|flagellar-transcriptional-regulator-FlhC
MATKSVSQEADEILLASSMITLGARLQVLQAETGLSHDRLARLYREIRGCSPPKGMLPFSVDWFMTWLPNIHSSLFYNVYTFLNQRTSSQGIRAVIDAYRLYLEHAPADAAEPVLSFTRAWMLVRFFDGGMLQLSGCRQCGGHFIAHAHDPQTDFVCAICRPPPRAGKTRAAARARAGQLAAPARP
>NZ_CP020818.1|WP_003811927.1|2803916_2804792_-|flagellar-motor-stator-protein-MotA
MLIVIGYAVVILAVVGSFIGLGGHLGALYQPFELTLIAGAAVGAFMAGNSRKSLGLVAKAIPEAFRSSPYSKDVYMELMALLYVLLNKARREGLMAIESHIEDPLSSPIFNEYPRIMKDAKLMEFITDYLRIMISGNMSSFEIETLMDEEIETYRHEREVPTHALQQVADALPAFGIVAAVLGVIKALAAVDQPPAILGDLISKAMVGTFLGVLLAYGFVAPMAARIERRTSESVKVLECIKVTLLASMNGYPPQLAVEFGRKVLFSAVRPSFGELEEHVRQAKSAATGRA
>NZ_CP020818.1|WP_003817154.1|2802956_2803904_-|flagellar-motor-protein-MotB
MSTVNNHRVVIRRRKVRRGGHHGGSWKIAYADFITAMMAFFLVMWLISIVPREELKGIAEYFRMPLRVALTGGPSSSAETSAIPGGGQDPLRSQGDVRRAEGNRVEAQPMGDAERRDRHRLERLKVRLENLIEESPVLKNFRPQLLIDMTTEGLRIQIVDNQNRPMFATGSADVQPYMRDILRELGPVLNDLPNKISIAGHTDASQYARGERAYSNWELSADRANASRQELVAGGMHEGKVLRIQGLASSMSLVKDDPFAAVNRRISLVVLNASTQRRIENENAAAADVNARDAQGVGAALAGQLAASGSDGGAR
>NZ_CP020818.1|WP_003811922.1|2802561_2802942_-|response-regulator
MTARILVADDSATMRMIVQAALTGAGWQVVTASDGKQALELAQAQAVDLVVSDWNMPVMGGLDLIRGLRGQARYQDLPVLVLTTEDDGDSKAAARDLGVCGWLNKPLDPDVLVDLAAELLGVAPGA
>NZ_CP020818.1|WP_033459377.1|2800477_2802535_-|chemotaxis-protein-CheA
MSSGLDLSQFYETFFDEADELLAQMEQLLLELDVGAPDIEQLNAIFRAAHSIKGGAATFGCFQKLAGTTHLLENLLDAIRRGEMGLRADMVDIFLETKDVLKSQLDAYRASEEPEDAVFERICAVLRQLALEGGQAPAAAAPAPVAAPEPDPEPEPAPQPAAASTAAGLPLRVRFSKVSDKDAQSLLEEMGNLGDVRASERAGQTLTVWVDTTCSPDDIEAVCCFIIDADQLEIAREAEPAHAPAQAAVAAAPDAAATPTPAPAPAAAQAAEPARAARPSIAPAHADKESTSIRVGVEKVDQVINLVGELVITQAMLAQTASTLDPVLHDRLLNGMEQLERNARDLQEAVMSIRMMPMDYVFSRFPRLVRDIAGKMGKQIELQTYGRATELDKSLIERIIDPLTHLVRNSLDHGIETPDKRVAAGKEPVGQLVLSAQHNGGNIVIEVSDDGGGLSRERILRKAVAQGLTVNENSPDDEIWQLIFAPGFSTADQVTDISGRGVGMDVVRRNIQDMGGHVQLSSVPGQGTTTRIVLPLTLAILDGMSVRVGEETFILPLNHVTESLQPQADQIYSVAGNERVMQVRGEYLPLVEMHRVFSVGQAQADPTQAIAVIMQAEERRFALLVDHLVGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVFALARANREKWSQPEAILN
>NZ_CP020818.1|WP_003811919.1|2799962_2800463_-|chemotaxis-protein-CheW
MAAKPHTQATRAEDVGNEFLVFTLGEEEYGIDILKVQEIRGYDAATVTRIANVPSFIKGVTNLRGIIVPIVDLRIKFNLGSVEYNEQTVVIILNLDRRVVGIVVDGVSDVLMLNAAQVRPAPEFGATLSTEYLTGLGTVDERMLILVDIEKLMTSDEMALVEKVAS
>NZ_CP020818.1|WP_110129059.1|2798182_2799889_-|HAMP-domain-containing-protein
MRKFLANLSIRGSLLGVLAFFSFMLVVGAALGVLSLRVSNDTLQGVKQTQDVADAMDRVVNSYKDALNGLGRAAASHYGAIVSAIGQPVQVEHGLGSEAAGLLQRAKASLNRAETEYEYYKGLARPASAADSLKEVENAFEALVGQGLHPLAAALEKGDMAGYQSHAQNVLDALEGRFSGAIAAFDFWRASELLDAHEVAETRYRFVLAAVAAGGVLAALLVFSTYLFLRRRVLQPLREVGQHFDKIAAGDLTARVDVRNSNEIGQLFAGLKRMEESLTRTVAAVRRGVDEINVGSREISAGNTDLSSRTEEQAASLEETAASMEQLASTVKQNADNARQANQLAGVASDVAERGGSAVSEVVTTMQDISASSRKISEIVSVIDGIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRSLAQRSAQAAKEIKVLIEDSVDKVGTGSQQVERAGATMQEIVASVKRVTDIMGEISAASEEQSSGIEQVNRAVSQMDEVTQQNAALVEEAAAAAGSLQEQAQRLAEAVAVFRINAGEVIDLPARQLGSRQAPGARETALARDDALALGH
>NZ_CP020818.1|WP_004567201.1|2797313_2798174_-|chemotaxis-protein-methyltransferase
MATAMTTPAFSAERQFEFRDADFARVRQMIYARAGISLGAHKREMVYSRLARRLRALGQQEFRVYLDGLENEPAAPEWEDFVNALTTNLTAFFRESHHFPILADFARQRGGPVSVWCCAASTGEEPYSIAMTLVESLGARAQASQVLATDIDTNCLQRARAGVYPYERVAKLDPARLKRFFMRGRGANEGQVKVRAELADMVRFETLNLLAPHWPINEKFDAIFCRNVMIYFDKPTQARILRRFVPLLKPGGLLFAGHSENFTYISRDFRLRGQTVYEQASGELPV
>NZ_CP020818.1|WP_004567204.1|2807403_2808579_+|flagellin-FliC
MAAVINTNYLSLVAQNNLNKSQSALGSAIERLSSGLRINSAKDDAAGQAIANRFTANVKGLTQAARNANDGISIAQTTEGALNEINNNLQRIRELTVQASNGTNSASDIDSIQQEVNQRLEEINRIAEQTDFNGIKVLKSNATDMTLSIQVGAKDNETIDIKIDRNSNWNLYDAVGTVPGGTVNGEARTVNALGFDVLSAVTTTIASDTVTFDAAVAAAEQAAGAAAGDGSVVSYGDTANPQYAVVVDNGGTLTSYALTFDKDGKAALGDQLGAVASQAAEAAVGVNDIASGDNVTVSGGNANALSKLDDAMKAVDEQRSSLGAIQNRFESTVANLNNTITNLSAARSRIEDSDYATEVSNMTKNQILQQAGTSVLAQANQVPQNVLSLLR
>NZ_CP020818.1|WP_110129060.1|2808801_2810592_-|dihydrolipoyl-dehydrogenase
MSNIVEIKVPDIGDFKEVEVIEVLVAAGDTIKAEQSLITVESDKASMEIPASSAGVVKSVKVKVGDKVAEGTVILDVEAAGEAAAAPKAEAPKAEAPKAEAPKADAPKAPAAKASAPAAAAYSGSADLECDMLVLGAGPGGYSAAFRAADLGMDTVMVERYATLGGVCLNVGCIPSKALLHNAAVIDEARALAAHGISFGEPKVDLDKLRGYKDSVVAKLTGGLAGMARARKVRVVTGTGEFADPHHLTVTDGEGKKQTIRFKQAIIAAGSQSVKLPFLPDDERIVDSTGALQLRAIPKKMLIVGGGIIGLEMGTVYSTLGARLDVVEMLDGLMQGADRDLVKVWQKMNAPRFDNIMLKTRTVGAEARKDGIYVSFEGEGAPKEPQRYDLVLQAVGRSPNGKKIGAERAGVAVTERGFIEVDRQMRTNVPHIYAIGDVVGQPMLAHKAVHEGHVAAEAAHGEKSYFDARVIPSVAYTDPEVAWVGLTEDEAKKQGVKVEKGLFPWAASGRAIANGRDEGFTKLLFDAETHRIVGGGIVGTHAGDLISEIALAIEMGADMVDIGKTIHPHPTLGESVGMAAEVAEGVCTDLPPMRKK
>NZ_CP020818.1|WP_033459366.1|2810604_2812281_-|dihydrolipoyllysine-residue-acetyltransferase
MSNIVEIKVPDIGDFKEVEVIEVLVSAGDTIKAEQSLITVESDKASMEIPASAAGVVKSVKVKVGDKIAEGTVILEVEAAGEAAAAPKAEAPKAEQAAETPKADAAKAEAPQAQAAQAEAPAAAGPIEVKVPDIGDFKEVEVIEVLVAEGDTIKAEQSLITVESDKASMEIPASAGGVVQSLKVKVGDKVAMGTVIAVVQGQGAAAPAAKAEAPAAAPAAAEPAAPASPVAPASAPAQRPAPAAALQDEDLKPGQLPHASPSVRKFARELGVNLSRVTGSAAKGRITADDVRAYVKQALSAGAPAGASGGGDGAALGLLPWPKIDFTKFGPIEAKPLSRIKKISGANLHRNWVMIPHVTNNDEADITDLEALRVALNKENEKSGVKVTMLAFLIKAVVAALKKFPEFNASLDGDNLVLKQYYHIGFAADTPNGLVVPVVRDADKKGILELARETSELARKAREGKVSPAEMQGGCFSISSLGGIGGTHFTPIINAPEVAILGVSRSAHKPVWDGKQFVPRLTLPLSLSYDHRVIDGAAAARFNAYLGQLLADFRRIAL
>NZ_CP020818.1|WP_003817149.1|2812293_2814999_-|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MSSFAQAGALAAANDEDTLETQEWLEALAAVLDREGPQRAHYLLERLIDEARRSGAHIPFSPNTAYVNTIPPGLEPAHPGNLELEARIRSYVRWNAMAMVVRANKHNPPDGGDLGGHIASFASLATMIGCGQNHFWHGETEEHGGDLVYFQGHTSPGMYGRAYLEGRLTEDQLNHFRQEVDGKGLSSYPHPKLMPDFWQFPTVSMGLGPLMAIYQARFLKYLHARGIADTSNRKVWVFCGDGEMDEPESLGAIALAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGSGWNVIKLIWGGYWDPLLAHDKEGILRRIMEEAVDGEYQAYKANDGKYVREHFFGKHPKLLEMVARMSDEDIWRLNRGGHDPHKVYAAFDAASKHAGQPTVILAKTIKGYGMGHVGQAKNPTHQQKKLELDSIREFRDRFGIPIPDDKLEELPYYKPAEDSPEMQYLHERRKALGGYLPKRRAKADEQLKAPALDAFKAVLEPTAEGREISTTQAFVRVLNQVLRDKDLGPRVVPILADESRTFGMEGLFRQIGIYAPEGQKYTPVDKDQVMYYKESADGQLLQEGINEAGAMSSWMAAATSYSTNNRIMVPFYIYYSMFGFQRVGDLAWAAGDMQARGFLLGGTAGRTTLNGEGLQHEDGHSHLLASTIPNCVSYDPTFAHELAVIIQHGLKRMVEDQENVYYYLTVMNENYPQPGLTAGDEEGIIRGMYKLKSHGKGKQRVQLMGSGTILREVMAAQELLEADWGVASDIWSVTSFTELRRDGLDAERHNLLHPEGKQQVPYVTTQLAKSDGPIIASTDYMKLFADQIRPFVPKDRTYKVLGTDGFGRSDFRYKLREHFEVDRHFVVLASLRALADEGKIPAAKVAEAIKKYGINPNKANPHHA
>NZ_CP020818.1|WP_003817147.1|2815291_2817046_+|PAS-domain-S-box-protein
MSSPPKSNIPMSFRDHARARRRGVYWLTPALVLVLYICVMGVFFWLQRIHDDSVMFVTIDQELRQQRLIWVVLALSCVIVISLLMLWRYTRFRSEAEAALIAETGFRRAMENSMSTGMRVLDMEGRIAYVNPAFCRMIGWNEADLIGRSPPFPYWVPGRHDQHQHTLEVLTSGKTPSSGLEVEAQRRDGSRFTARMYVSPLLDPNGDQIGWMTSMTDITEPKRIREALTAAHERFMTVLEGLDDAISVTADTHDGLELLFANRTYRRVFGAQTGGHDELLAGRRGRFTDESVEVFAPSVQRWFEVHHRMLAWTDGRRVRMQVARDITERRVHEEASRVQQEKIQLTSRLTTMGEMASSLAHELNQPLTAIANYSMGAVALVKAGHTSPNMLLPALEKAASQAERAGKIISRIREFVKRSEPRRQRVAISRIVDNAIGFAEIDARKRRIRIERFVPSNAPDVLADPILIEQVLLNLLKNGLEAMEKSESDELKVAVIPHEQHIEVAVVDRGHGLPEPERLFEPFFSTKSQGLGMGLNICRTIIESHHGRLWADPNPAGGTIFRFTLPCATPQSQAQNDQSEELHA
>NZ_CP020818.1|WP_003811946.1|2817042_2817669_+|response-regulator-transcription-factor
MNTPHLSSTVFIVDDDEAVRDSLRWLLEANGYRVRAYASGENFLDEYDASQIGVLIADVRMPGMSGLELQEQLIARNAPLPIVFITGHGDVPMAVSTMKKGAVDFLEKPFNESDLREIVARMLEQAVQRISKFQAQKDHEAMLARLTAREQQVLERIVAGRLNKQIADDLGISIKTVEAHRANIMEKLEVTTVADLMKVALAKPEAHA
>NZ_CP020818.1|WP_003811948.1|2817665_2818517_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD
MTARIIDGAALSQRIREEVAQRVQALTAKGVRPGLAVVLVGDDPASQVYVRNKVAACEKAGLHSVKEQYPADLTEAQLLERIDALNRDPSIHGILVQLPLPRHMDAHKVIEAIAAEKDVDGFHISNAGLLMTGQPLFRPCTPYGVMKMLESEGVALRGAEAVIVGASNIVGKPMAMLLLQAGATITICNSKTRDLGAQTRRADVLVVATGKPGMIDGSMIKPGAVVIDVGINRGADGKLCGDVDMASAREVAGAISPVPGGVGPMTIAMLLVNTVEAAERAAA
>NZ_CP020818.1|WP_080699493.1|2818592_2820707_+|M3-family-metallopeptidase
MACAPFGLRPLVHGISKPMTQNPLLAPVADLVDYAAVKPEHIVPAVQALLDIARAAVEHAADPALPATWDAVVAPLDSASERLWRAWSVAGHLNAVVNTPVLREAYNAALPLVTEFSTWVGLHEGLYRQYQRLQAAEDFAAWPPVRRRVVELALRDFRLSGVELQGAARERYAEISDREAQASQKFSENVLDAIDAWSLLVDDQARLDGIPADVLAAARKAAEDDGATGWKLTLKMPCYLPVMQYARDRALRETLYRAYGTVASEHGDAAYDNSPLIEELLQLRADEAGLLQYPTFAALRLQTRMARDATEVVDFLRDLARRAKPYAERDLAELQAFAAGELGLAELQPWDVPFAAERLRESRYAYSEDEIKQYFTEPRVLAGLFEVIETLFDVRLREVPVSSWHADVRGVRVESPDGATLGHLYLDLYARAGKQSGAWVDSERSRRRVQGDLQTPVAYLTCNFSRPNGDKAALLTHDDVITLFHETGHALHALLSEVDEPGAAAFASVEWDAIELPSQFMENFCWEWSVVQKLSAHVETGQPLPRDLYDRLVAARNFQSGMQTVRQIEFALFDMMLHDRPQGAPIADVLALLQQVRQEVAVLFPPAWHRLPHSFSHLFAGGYGAGYYSYKWAEVLSADAYEAFEEAARQGEPAATTLDGATGARFRKEILAVGGARPAADSFRAFRGREPRIDALLRHSGMQA
>NZ_CP020818.1|WP_033476086.1|2821034_2822018_+|IS110-family-transposase
MFFIGIDVSKAKLDCTLLTAEADKRKTKVVVNTAAGVQALLAWCAKHGAQPAQLHAILEPTGLYHEQAATALHDAQVRVSLVNPAQARDFAKALAMRSKNDALDSYVLARYGQTLSPALWHPAPLHARQLRALLTRREALGKDLLRELNRKEKSQFSPSAPLVDGSIDKAIAFLREQIKQIERAIDQHIDNHPDLKQDRELLNSIPAIGPQAGNAILAVMHNRRIDSAQTLAAYLGVVPVQRQSGSSLNGCARLSKAGPSQVRATLYMAALVGTRHNPHIRALYQRLLKAGKSKKAALGAAMRKLVHLCFGVLKNRIPYQPNYAMNA
>NZ_CP020818.1|WP_003817144.1|2822141_2822792_+|SCO-family-protein
MRAPRRRLAVSTMYSPLSGRAWRGLLLAMLMLLAACSERSADWSLYNVKGHLPDLKFSLPGAHGKTVSSDDLKGKTVLLFFGYASCPDVCPTTMAQLTAVLQQLGEQARDVRILFVSVDPHRDTPDILQAYVNAFNNNAIGVTGNEKQIADLARRYRVAYQIEKPKPGDDADIYDVTHSRGVYIFDNQGKARLLASDTDTIDTMVKDLRQLIAQTQ

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Crispr_ID: NZ_CP020818_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_6

4053926-4054007

Orphan

Consensus_repeat	Method
CTGTCCCCGCCGGGACAGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020818_6

>merge|NZ_CP020818|6|4053926-4054007|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACCCGTCGTGCGCCATGAGCGCCATTGCCAGGACGGCGTCTGTCCCCGCCGGGACAGGCGCC

>NZ_CP020818|6|6|4053926-4054007|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACC	CGTCGTGCGCCATGAGCGCCATTGCCAGGACGGCGT
CTGTCCCCGCCGGGACAGGCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_003814079.1\|4055236_4057162_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP020818.1\|WP_003814066.1\|4047693_4048581_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP020818.1\|WP_003814092.1\|4060925_4061825_+\|NAD-kinase	unknown	unknown	gnl\|CDD\|179379
NZ_CP020818.1\|WP_003814063.1\|4046804_4047167_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP020818.1\|WP_003814085.1\|4058336_4058579_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_003821191.1\|4044869_4046126_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP020818.1\|WP_003821189.1\|4048602_4049775_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226346
NZ_CP020818.1\|WP_004566476.1\|4061840_4063502_+\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP020818.1\|WP_003814061.1\|4046328_4046754_+\|DUF1841-family-protein	unknown	unknown	gnl\|CDD\|370177
NZ_CP020818.1\|WP_003821187.1\|4051078_4053829_+\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP020818.1\|WP_110129095.1\|4057252_4057633_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP020818.1\|WP_004566474.1\|4058660_4059749_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_CP020818.1\|WP_004566462.1\|4043690_4044671_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP020818.1\|WP_004566468.1\|4049778_4050333_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP020818.1\|WP_003814083.1\|4057640_4058195_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237621
NZ_CP020818.1\|WP_003814098.1\|4063979_4064399_-\|ferric-iron-uptake-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366663
NZ_CP020818.1\|WP_003814065.1\|4047179_4047533_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP020818.1\|WP_003821182.1\|4059806_4060811_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP020818.1\|WP_003814072.1\|4050370_4050745_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_003821186.1\|4054014_4055136_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|236757

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_003814079.1\|4055236_4057162_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP020818.1\|WP_003814066.1\|4047693_4048581_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.30038e-45
NZ_CP020818.1\|WP_003814092.1\|4060925_4061825_+\|NAD-kinase	gnl\|CDD\|179379	PRK02155, ppnK, NAD kinase.	0
NZ_CP020818.1\|WP_003814063.1\|4046804_4047167_-\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	2.60442e-23
NZ_CP020818.1\|WP_003821191.1\|4044869_4046126_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP020818.1\|WP_003821189.1\|4048602_4049775_+\|VWA-domain-containing-protein	gnl\|CDD\|226346	COG3825, COG3825, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP020818.1\|WP_004566476.1\|4061840_4063502_+\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
NZ_CP020818.1\|WP_003814061.1\|4046328_4046754_+\|DUF1841-family-protein	gnl\|CDD\|370177	pfam08897, DUF1841, Domain of unknown function (DUF1841). This family of proteins are functionally uncharacterized.	2.9417e-76
NZ_CP020818.1\|WP_003821187.1\|4051078_4053829_+\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	3.06874e-64
NZ_CP020818.1\|WP_110129095.1\|4057252_4057633_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.36045e-05
NZ_CP020818.1\|WP_004566474.1\|4058660_4059749_-\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	3.4326e-159
NZ_CP020818.1\|WP_004566462.1\|4043690_4044671_-\|hypothetical-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.59109e-14
NZ_CP020818.1\|WP_004566468.1\|4049778_4050333_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	1.87052e-61
NZ_CP020818.1\|WP_003814083.1\|4057640_4058195_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237621	PRK14139, PRK14139, heat shock protein GrpE; Provisional.	1.18525e-78
NZ_CP020818.1\|WP_003814098.1\|4063979_4064399_-\|ferric-iron-uptake-transcriptional-regulator	gnl\|CDD\|366663	pfam01475, FUR, Ferric uptake regulator family. This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.	1.74636e-59
NZ_CP020818.1\|WP_003814065.1\|4047179_4047533_-\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	6.05638e-23
NZ_CP020818.1\|WP_003821182.1\|4059806_4060811_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	5.93958e-145
NZ_CP020818.1\|WP_003821186.1\|4054014_4055136_-\|molecular-chaperone-DnaJ	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	0

>NZ_CP020818.1|WP_003821187.1|4051078_4053829_+|insulinase-family-protein
MRLPLLSRRLNALLVSSFLAFQAGAASLPAGVSEVSSIEGITEYRLANGLRVLLAPDASKPTTTVNMTYLVGSRNENYGQTGMAHLLEHMLFKGTPAIRNALGEFSRRGLQANGSTSSDRTNYFASFAANPETLKWYLGWQADAMVNSLIAKEDLDSEMTVVRNEMESGENNPFRVLMQKMQAAAYQWHNYGKSTIGARSDVENVDIAQLRAFYHEYYQPDNAVLIVAGKFDPQTALADIQSSLGKLPKPKRTLPPEYTVEPVQDGERSVTLRRAGGTPLVAAMYHLPAAGSPDFVGLDLAATILADTPSGRLYHALVPTKLASGVFGFTMDQLDPGLAMFGAQLQPGMDQDKALQTLTATLESLSSKPFSQEELERARSKWLTAWQQTYADPEKVGVALSEAIASGDWRLFFLQRDRVRDAKLDDVQRAAVAYLVRSNRTEGRYIPTEKPQRAPLAQRADLAAVFKDYKGDPNFKAVEAFDPSPANIDKRTLRRTLDLPNGQVELALLPKATRGDRVQAELLIQFGDAEALRGQRVPLAAAAALLDRGTDKLSRQAIQDRLDQLQAEAAINGSGTNLVVNISTLGKNLPDVMALVLDVVRNASFPQDQVEEYKRQAITMVQDAMTDPTALASRALARHNNPWPADDVRYVPTFDEALEQLRSLSRDDLAAVSGKLYGAGRIKFSAVGEFDPAAVEAVLRKGLDGWRSAPAYTRLPDPYRAVPAQQFDIATPDKANAFYISRMPLQLQDTNADYPALYLANFLLGTSETSRLWHRVRETEGLSYNVRSNLSVSSYEPSANWTIYAIYAPQNRARLEKAISEELARALKDGFTDQEVRDGVVALLNYRNLARAQDDVLADTWVNYMQTGRSFQWSADMDRKLEALTPDQVNAALRKYLKPDAFSTAVAGDFTKKSAP
>NZ_CP020818.1|WP_003814072.1|4050370_4050745_-|hypothetical-protein
MLTDIVTRALSQLLGNSLSGDVIKGRFRYAYASDDGRFVAILGHDLTTYVVDVDAQRYFAECAGVPCGFAGHVLEMEGAQEHGHPWPAVNDLFDLDMDGDEIAWRRCPGAVALAATRQAQSRVA
>NZ_CP020818.1|WP_004566468.1|4049778_4050333_-|N-acetyltransferase
MNATPSPAPTGATLVDCTHDRHAAAILDIFNDAILTSTALYDYQPRALASMEAWFQAKRQGGFPVVGFEDAAGVLMGFASYGTFRAWPAYKYSVEHSVYVDRRYRGRGLGEALLRALIERARLQQVHVLVGGIDATNAGSVALHRKLGFVHAGTITQAGFKFGRWLDLAFYQLTLDTPLRPVDG
>NZ_CP020818.1|WP_003821189.1|4048602_4049775_+|VWA-domain-containing-protein
MLIDFFYHLRAHKLPVSVQEYLTLLEALRQRLMAPTLDDFYFLARTALVKDESLYDRYDAAFGAYYRGIAAALPADRDIPLDWLIKEFEKTLTPEEKAAIEAHGWDKLMELFKQRLEEQQERHAGGSKWIGTGGTSPFGNGGYHPEGIRVGGDSAGNRTAVKVWDMRQFRDYDDQLELGTRNFKVALRRLRRFARQGADLELDLDDTIASTARNAGHLDLRLVPERRNTVKVLMLLDVGGSMDDHIARVEELFSAARSEFRHLDVYYFHNCPYENLWQNNRRRQNERFDTWDVLRKYNADWRLIIVGDATMSPYEILQPGGSVEHYNKEAGAVWLRRLLDAWPKAAWLNPEPTASWRYRQSIALLRDIMQDRMYPVTVAGLEQAMRQLSK
>NZ_CP020818.1|WP_003814066.1|4047693_4048581_+|MoxR-family-ATPase
MPTSASSSSAPAQSARFEGTDRYVATDDLKLAVNAALTLQRPLLIKGEPGTGKTMLAEEVARALDRPLLQWHIKSTTKAHQGLYEYDAVSRLRDSQLGDEKVRDIRNYIVQGTLWQAFEAPEPVVLLIDEIDKADIEFPNDLLRELDRMEFHVYETRQTVQARHRPLVIITSNNEKDLPDAFLRRCFFHYIRFPDRDTMRDIVGVHYPDIRQDVLRAALDTFFALREAPGLKKKPSTSELLDWLRLLLAEAIPAAEIDAHAATAVPVLAGALLKNEQDVHLLERLGAMARGAQRR
>NZ_CP020818.1|WP_003814065.1|4047179_4047533_-|cytochrome-c
MKLRISMTRTVSVLAVLASCAIAGPAAAADAAPVGNAQNARDKVSMCIGCHGIPGYKASFPELYHVPMIAGQNAKYIEAALNEYRKGARSHPTMDAVAGSLSDQDIADLAAYYSSLK
>NZ_CP020818.1|WP_003814063.1|4046804_4047167_-|cytochrome-c
MKRFTFALAGIVLATAGVSAQAQDVVAGKAVFDKFNCASCHGADAKTSVQPEYPVLAGQHADYLAHALKAYKRGAAGSAATANVRKNPIMGAFAAQLSDQDIRNVAAWLAAQPSDLGVRQ
>NZ_CP020818.1|WP_003814061.1|4046328_4046754_+|DUF1841-family-protein
MFNPSRDQVREFFIETWRKHRATEVLTPLESMALDWILEHPEYHGDLESPEAMTAEYPVEHGRTNPFLHLSMHLAIAEQLSIDHPRGIRAAYQRLVGRGDAHQAAHEIMECLGQVVWEAQRLGTPLDSDAYIELIRQRAER
>NZ_CP020818.1|WP_003821191.1|4044869_4046126_-|NADP-dependent-isocitrate-dehydrogenase
MSYQHIKVPTGGQKITVNADYSLNVPDQVIIPVIEGDGTGADITPVMIKVVDAAVQKAYAGKRKIHWMEVYAGEKATKVYGPDVWLPEETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEYMAESEQAKDLIQYLQTKLGATKIRFPNTSSIGIKPVSREGTERLVRKALQYAIDNDRASVTLVHKGNIMKFTEGGFRDWGYALAQNEFGAQPIDGGPWCKFKNPKTGREIIVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
>NZ_CP020818.1|WP_004566462.1|4043690_4044671_-|hypothetical-protein
MAKPASDMPPYDKAAALRGLAGARRVALLMAPRLGDTLLMMNMARNLAAHGREVSIFGDYIHGLRDWFPGLDIRPSLSEEQAGQVLPGYDCAAQMHVGWPYALHAHQPNYFYYDAHVVITGRGFVKLFQIRDFCREQLGLAQAGADNGLRPPPQVQPHRSHPRRVALHPTSTGAQRCWAPRHFKELGLRLLHEGYEPNYIVAPHERAEWSWVLDHGLHLPQFPSLSEVAGFIHASGWFIGNESGIGHLASNVGVPTLSLTGRPTRTRAWRPAWSTSRIVYPALIPGGRWRDRLWREWLSPRRVMSAFHKLQADDRRQPVGVPWGKI
>NZ_CP020818.1|WP_003821186.1|4054014_4055136_-|molecular-chaperone-DnaJ
MAKRDYYEVLGVAKNASDEDLKKAYRKLAMKYHPDRNPDSKEAEEKFKEAKEAYEVLGDEQKRAAYDRYGHAGVDPNAAGMGGGMGGGFADAFGDIFGEIFGAGRRGGGGPQVYRGADLKYALEITLEQAASGFDTEIRVPSWENCDTCHGSGAKAGTSPKTCRTCGGSGAVRMQQGFFSVQQTCPTCHGTGKEITDPCPSCDGVGRTRRNKTLQVKIPAGIDDGMRIRSSGNGEPGINGGPPGDLYVEIHIKQHKIFQRDGDDLHCELTIPFTTAALGGELQVPTLGGKAEISIPEGTQSGKTFRLRAKGIRGVRGSYPGDLYCHVVVETPVRLSDEQKAILRQFEASLNDGGDRHSPQSKSWTDRVKEFFS
>NZ_CP020818.1|WP_003814079.1|4055236_4057162_-|molecular-chaperone-DnaK
MSKIIGIDLGTTNSCVAVLDGGQVKIIENAEGARTTPSIVAYMDDGETLVGAPAKRQAVTNPKNTLYAVKRLIGRKFDEKAVQKDIDLMPYSIVKADNGDAWVEVRGKKLAPPQVSAEVLRKMKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKTEKGDRKIVVYDLGGGTFDVSIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIISEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSSQQTEINLPYITADASGPKHLNLKITRAKLEALVEELIERTIEPCRVAIKDAGVKVSDIDDVILVGGMTRMPKVQDKVKEFFGREPRKDVNPDEAVAAGAAIQGSVLSGERKDVLLLDVTPLSLGIETLGGVMTKMIQKNTTIPTRYSQTFSTADDNQPAVTIKVFQGEREIAAGNKGLGEFNLEGIPPAPRGLPQIEVTFDIDANGILHVSAKDKGTGKENKITIKANSGLSEDEIQRMVKDAEANAEEDHRLAELAQARNQADALVHATRKSLTEYGEKLEAAEKESIEAAIKDLEDILKTGDKAEIDAKVEALSTASQKLGEKMYADMQAQQQAQQQQAADNAKPVDDNVVDADFKEVKRDQ
>NZ_CP020818.1|WP_110129095.1|4057252_4057633_-|thioredoxin-family-protein
MAAAPFDPAEVFQVFGMRRVDSASFDEQVVQAPGDDLRCVFLWGQDCYNCGIFKQAALLQRQALLALELSWFEADVYADEALGRRFSLHGVPTFVLYRSGKRLGRVTGWPGLPQFSAAMQRLRDGT
>NZ_CP020818.1|WP_003814083.1|4057640_4058195_-|nucleotide-exchange-factor-GrpE
MTAPQEPVDSTPESGENAATPGLEDDLSAELAALRAELEAAQATVKAQQEQVLRAAAEAENVRRRAQEDVAKARKFGIESFAESLVPVKDSLEAALAQPDQAAQAWREGVEVTLKQLTAAFERNLLKEIAPAQGDKFDPHLHQAISSVPADQPANTVLQLLQKGYVIADRTLRPALVVVSAGQG
>NZ_CP020818.1|WP_003814085.1|4058336_4058579_-|hypothetical-protein
MNPPRKPTIGTSGPPGHANLEEDQLERELDEALLETFPASDPIAITSEDERDEPDDKVDEALEDTFPASDPPAPAQPGKK
>NZ_CP020818.1|WP_004566474.1|4058660_4059749_-|ferrochelatase
MFLRLFKYLWPERYLPETPAQDPFDENPPPCGPGRVGVLLVNLGTPDEPTRGAIRQYLGEFLSDPRVIEIPRYLWMPILHGLVLTMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQGLAARGVHAEVELAMRYGKPSIPAAIAALRERGCDHILAVPLYPQYAASTTATVVDAVTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSFHGLPRYSIELGDPYYRDCLDTARLLRERLGLREDEVEVTFQSRFGSARWLEPYTEPTLAELARQGVTEVDVVCPGFVADCLETLEEISQECRDAFVAAGGRQFRYIPALNDCPPWIEGLTDLVERQLRGWPTGNP
>NZ_CP020818.1|WP_003821182.1|4059806_4060811_-|heat-inducible-transcriptional-repressor-HrcA
MDDRARALLKALIERYIADGQPVGSRTLSKVFDLSPATIRNVMADLEELGLIHSPHTSAGRVPTPRGYRMFVDSLLAVRAYQFEPAHIGELLPVSEPSRAVNAAAALLSNLTQFAGVVLTPKRTQIFRQIEFIRLSDKRVLLIIVTPEGDVQNRILSAQRDYTEAELLEAGNFFNVHFSGKSFDAVRRTLSTELAQLRDDISRLMQAAVEAGAEAADDGEAVVISGERKLLDVTDIASDMDRLRKMFSLFEKKTDLLQLLDVSSRAQGVQIYIGGDSQLVPMEEVSVITAPYGLDGKVIGTLGVIGPTRMAYERVIPIVDITARLLSNALSHNQ
>NZ_CP020818.1|WP_003814092.1|4060925_4061825_+|NAD-kinase
MYFPIVALIGRYQDTGLDAPLTALAQMLTQAGRRVLVEAETARNAGVSGYPVADWDEIGRTATLAVVMGGDGTVLGAARHLAPYGVPLIGINHGRLGFITDIPLQDAHDALGRVLEGNYQAEDRMLLQGGVWRGEQQMYSASAVNDVVLNRAGRGGMIEVRVELDGAFMYTQRADGLIIATPTGSTAYSLSANGPILHPGMNAMVLVPVAPQTLSNRPIVIPDSGVLNMTLTAMGRVEIGASVHFDMQTWSDLQPGDRITVQRAPHTIRFVHPEGYSFFSTLRRKLHWNLMPQATDNLE
>NZ_CP020818.1|WP_004566476.1|4061840_4063502_+|DNA-repair-protein-RecN
MLRTLHIRDFVIVEQTELHFGDGFTVFSGETGAGKSILIDALALTLGERGDASMLREGAARADITAVFDAPPALRDWLAERELDSGDELALRRVIDSQGRSRAYINGMPATIAQLRELGDGLVDIHGQHAHQSLMRPDAQRDLLDAHGGHAELRQTVAQAWKQWRALARQLDTAEQDAEALAAERDRLQWQSDELDRLGLGPDEWDALQTEHTRLSHAQSLLDGASRILEALDGEHDSAQHRLNGAAHQLQQMLRHDPALQGIGDELESARIAITEAVSDLNNYVSRVELDPQRLADVEARLSAVFETARKFKCEPHDLPALRDSLHGKLAEMQAASDVQALRAQAEAAQARYEAAAARLSAARRKIAKDLGKQVTQAMQTLSMQGGRFEAALTGGAPSAHGSEQVEFLVAGHAGSTPRPLAKVASGGELSRISLALSVIASRAARVPTLIFDEVDSGVGGAVAEAVGKLLRELGQRHQVLCVTHLPQVAACAHAQYRVSKVESGGSTRSRIAELDAEARVEEVARMLGGIKITATTRDHAREMLGGHTAPAA
>NZ_CP020818.1|WP_003814098.1|4063979_4064399_-|ferric-iron-uptake-transcriptional-regulator
MSDQSELKNMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHDHLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGICGNCQKGR

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Crispr_ID: NZ_CP020818_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_7

4568334-4568428

Orphan

Consensus_repeat	Method
GTGCCTGTCCCCGCCGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020818_7

>merge|NZ_CP020818|7|4568334-4568428|CRISPRCasFinder
GTGCCTGTCCCCGCCGGGACAGGCACCCGGGCCCAGGAAAGACCCCCACGCTGCGCCCGCTGTGCGGGCGTGCCTGTCCCCACCGGGACAGGCAC

>NZ_CP020818|7|7|4568334-4568428|CRISPRCasFinder
GTGCCTGTCCCCGCCGGGACAGGCAC	CCGGGCCCAGGAAAGACCCCCACGCTGCGCCCGCTGTGCGGGC
GTGCCTGTCCCCACCGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_015041882.1\|4558012_4559041_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|366103
NZ_CP020818.1\|WP_003820698.1\|4572003_4572663_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP020818.1\|WP_003820699.1\|4571092_4572007_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP020818.1\|WP_033461063.1\|4575424_4577044_-\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|224720
NZ_CP020818.1\|WP_003814701.1\|4568500_4568971_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP020818.1\|WP_033450541.1\|4556752_4557946_-\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180775
NZ_CP020818.1\|WP_003814709.1\|4572752_4573676_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP020818.1\|WP_003820700.1\|4569059_4569404_-\|TIGR01244-family-phosphatase	unknown	unknown	gnl\|CDD\|225984
NZ_CP020818.1\|WP_003814711.1\|4573681_4574137_-\|multidrug/biocide-efflux-PACE-transporter	unknown	unknown	gnl\|CDD\|226610
NZ_CP020818.1\|WP_003820703.1\|4565464_4565983_+\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP020818.1\|WP_033450536.1\|4562391_4563177_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181723
NZ_CP020818.1\|WP_003814699.1\|4565979_4568103_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NZ_CP020818.1\|WP_003814704.1\|4569503_4570904_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP020818.1\|WP_157734656.1\|4575195_4575465_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP020818.1\|WP_033472576.1\|4574133_4575237_-\|ChbG/HpnK-family-deacetylase	unknown	unknown	gnl\|CDD\|212118
NZ_CP020818.1\|WP_003820706.1\|4561353_4562325_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP020818.1\|WP_080699460.1\|4559067_4560228_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP020818.1\|WP_003814694.1\|4564598_4565354_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
NZ_CP020818.1\|WP_003820704.1\|4563169_4564402_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP020818.1\|WP_003820707.1\|4560365_4561343_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_015041882.1\|4558012_4559041_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|366103	pfam00441, Acyl-CoA_dh_1, Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	7.97783e-13
NZ_CP020818.1\|WP_003820698.1\|4572003_4572663_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	3.59851e-32
NZ_CP020818.1\|WP_003820699.1\|4571092_4572007_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.28877e-09
NZ_CP020818.1\|WP_033461063.1\|4575424_4577044_-\|glycosyltransferase-family-39-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	1.18448e-51
NZ_CP020818.1\|WP_003814701.1\|4568500_4568971_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.38587e-30
NZ_CP020818.1\|WP_033450541.1\|4556752_4557946_-\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180775	PRK06954, PRK06954, acetyl-CoA C-acetyltransferase.	2.70376e-175
NZ_CP020818.1\|WP_003814709.1\|4572752_4573676_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	2.97616e-21
NZ_CP020818.1\|WP_003820700.1\|4569059_4569404_-\|TIGR01244-family-phosphatase	gnl\|CDD\|225984	COG3453, COG3453, Uncharacterized protein conserved in bacteria [Function unknown].	3.40043e-35
NZ_CP020818.1\|WP_003814711.1\|4573681_4574137_-\|multidrug/biocide-efflux-PACE-transporter	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	2.35069e-54
NZ_CP020818.1\|WP_003820703.1\|4565464_4565983_+\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.24362e-44
NZ_CP020818.1\|WP_033450536.1\|4562391_4563177_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181723	PRK09245, PRK09245, crotonase/enoyl-CoA hydratase family protein.	9.0736e-157
NZ_CP020818.1\|WP_003814699.1\|4565979_4568103_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_CP020818.1\|WP_003814704.1\|4569503_4570904_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.52472e-110
NZ_CP020818.1\|WP_157734656.1\|4575195_4575465_+\|hypothetical-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.82605e-06
NZ_CP020818.1\|WP_033472576.1\|4574133_4575237_-\|ChbG/HpnK-family-deacetylase	gnl\|CDD\|212118	cd10807, YdjC_like_3, uncharacterized YdjC-like family proteins from bacteria. This subfamily contains many hypothetical proteins, and belongs to the YdjC-like family of uncharacterized proteins from bacteria. The YdjC-family is represented by an uncharacterised protein YdjC (also known as ChbG) encoded by the chb (N,N'-diacetylchitobiose, also called [GlcNAc]2) or cel operon in Escherichia coli, which encodes enzymes involved in growth on an N,N'-diacetylchitobiose carbon source. The molecular function of this subfamily is unclear.	7.22423e-93
NZ_CP020818.1\|WP_003820706.1\|4561353_4562325_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.39784e-117
NZ_CP020818.1\|WP_080699460.1\|4559067_4560228_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	7.48733e-84
NZ_CP020818.1\|WP_003814694.1\|4564598_4565354_-\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	1.14565e-78
NZ_CP020818.1\|WP_003820704.1\|4563169_4564402_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.64046e-118
NZ_CP020818.1\|WP_003820707.1\|4560365_4561343_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.29992e-59

>NZ_CP020818.1|WP_003814699.1|4565979_4568103_-|elongation-factor-G
MTRRTSIERYRNIGISAHIDAGKTTTTERILFYTGITHKLGEVHEGAATMDWMEQEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYGVPRIAFVNKMDRVGADFFRVQRQIVERLKGDAVPIQIPVGAEDHFEGVVDLVKMKAIIWDDASQGVRFEYRDIPPELQAQAEQWREKMIEKAAEANEALLEKYLSGQPLSEDEIKSGLRARTVANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAIIGHDERDREIERHPADDEPFSALAFKIMTDPFVGQLVFFRVYSGVVKSGDSVLNPLKSKKERLGRILQMHANERREISEVYAGDIAAAVGIKEITTGDTLTDPAHVIILERMTFPEPVISQAVEPRTKADQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRSTVTDVEGKFVKQSGGRGQYGHVVLKLEPQEQGKGYEFVDAIKGGVVPREFIPAVDRGVRETLNTGVLAGYPVVDVKVTLVFGSYHDVDSNENAFRMAASMAFKEGMRRAKPVLLEPMMHVEVETPEDFTGNVMGDLSSRRGMVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSLTQGRATYSMEFKHYAEAPRQVAEQIIAARGSGAAARG
>NZ_CP020818.1|WP_003820703.1|4565464_4565983_+|MgtC/SapB-family-protein
MDTVWTEIWTTVRNEFADIPDVAEATRIVLRLGMAVALGGLLGYERERSGKAAGLRTHMLVALGAALFVLVPLQGGMEVGDLSRVLQGVIAGIGFLGAGAIIKLGNEGEIRGLTTSAGIWLTAAIGVAAGMGREATALASTLIALFVLAALRRLEKRIAARDDKRVVAQPPP
>NZ_CP020818.1|WP_003814694.1|4564598_4565354_-|TerC-family-protein
MDYLVSLAQQPAAWAALATLIAMEVVLGIDNLIFISILTNKLPPQHQTKARRIGIGMALILRLALLGTVAFIVQLTQPVFELFGHGFSWRDVILVAGGLFLVWKATKEIHHHVDPNPGDDMFGGKAATLGFAAAVAQILMLDLVFSIDSIITAVGMTEHIPIMFVAVIVAVAVMLLAAEPLARFIERNPTVVMLALAFLMMIGMTLIAEGFGAHVPKGYIYAAMAFSALVEGLNMMARRAREGRGAGAAGG
>NZ_CP020818.1|WP_003820704.1|4563169_4564402_-|CoA-transferase
MSGPLEGVRILDVTTVLMGPYATQILGDLGADVIKVEPPAGDNVRGIGPGRHADMGGIFLHANRSKRSIALDLKKPAGREALLKVAATCDVLVYNVRPQAMARLGLSYAEVAQANPSILYVGMYGYDQRGPYAARAAYDDLIQGAVGIPSLSVEAGSDIPRYAPSAMVDRIVGISAANAVTAGLYHRARTGQGQAIDVPMFETMAHLILGDHMMGQTFEPPLGPPGYPRILNADRRPYATRNGHICVLLYADKHWKAFFELIGQPGRDAADPRFRDIGTRTQHIHAIYRLVSDAIASRTTEEWLAAFEAADIPAMPVHTMASLLRDPHLEAIGFFGTVDHPSEGAVRMMAVPSRWSGTPPQPRGHAPRLGEHSVDVLKEAGYDDEAIAALVRDGAAIAAARQRPEGTDHD
>NZ_CP020818.1|WP_033450536.1|4562391_4563177_-|crotonase/enoyl-CoA-hydratase-family-protein
MTDFLRHERHGGVLLLTMDRERTRNALSDADAVEALVQACARIGADLSVRAVVLTGSHGVFSSGGNLKTLSDTVGAGLGEPVHSRQAYRSGIQRIPLALYNLEVPTIAAVNGPAIGAGCDLACMCDIRLAARQASFAESFVKLGLTPGDGGAWLLPRIVGMSRACELAFTGRSIDAARARELGLVSEVFDADALLPAALALAQEIAQHSGHALRLTKRLLREGQHTRLDTLLELSAGFQALAHHTQEHAGALDAYLSRKRD
>NZ_CP020818.1|WP_003820706.1|4561353_4562325_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MHPRTLALAVLSVAALAQGGSARAASDYPAHPVKIIVSLPPGSGADTTARFLSKHLAERFKQPFVVENRPGANSFIAAQAVATAPPDGYTLFVASNSPMTTNAAVFKNLPYDALKDFAPVAPIARFPMALVVPANSPYRSVADLVAAARAAPGQLNFASGTATYQVVLELFHEQNGIKATHVPYKGTSAALADVAGGVVQYSVADVSAALPLIRGGKLRPLAVTSTRRIKDLPDVPTMQESGNKGFEAYAWTAAFFPAKVDPAIVARVSDAVQALVRSEEGKAFMEQLGGEPFVGGPATLAAFQRDELASMRRIAKLANIQQE
>NZ_CP020818.1|WP_003820707.1|4560365_4561343_+|LysR-family-transcriptional-regulator
MWTGQYIVHIASPAHHWRRAVELRQLKQLLVLSETLNFHRAAERLHMAQPPLSTAIKKLEQELGVQLFERLPAGLQPTPAAEVVLRYARATLFYADEIQRAAQEGASGKQGMLKVGFVGSSVYSLMPQLLSAFRKDYPRVDLVIEESTTVDLLRRLDAHTLDVALVRFPVLEPSTARITLLQADHLMLAVPAGSRYAQRDDVALDELADEPFIGYSRTHVPGMHALVMYAFQQYGVVPHITQEAIQVQTILSLVESGLGLAIVPKVAGRQAGSGVRLVNVPQLAETIKVGIALAVHPDNATPTTANFVDMACRLMQTEPAAGQAR
>NZ_CP020818.1|WP_080699460.1|4559067_4560228_-|acyl-CoA-dehydrogenase
MGTIIEALQLAAIPARDEALRPAVRAFLDEALREMPADRRARSWMGHDAEFSRALARQGWLGLTLPVEYGGAGRSNFARFVLSEELLAAGAPVSAHWIADRQTAPLILRFGSPAQRAFYLPRIIRGEAFFAIGMSEPDTGSDLASVRTRATPVADGWLLNGRKIWTTNAHRSHYMCALVRTSGAPEDRHRGLSQMIFDLALPGIEIRPIRDIAGDAHFCEVLFDNVLLPHDALVGEEGSGWRQVMAELALERSGPERIYSSMVLLDGWLAHLRRDAAPQRAQVCLAGRLAARLAVLRSMSLAVSQRLEQGADASLAAVLVKDLGTEFEQAVPELIGQALRASPQPAPGDVLMRTLAYLTLINPTFSLRGGTRHILRGIIARELGLR
>NZ_CP020818.1|WP_015041882.1|4558012_4559041_-|acyl-CoA-dehydrogenase
MVSTMQQDLYETFARALAGLCPLERVRELEAAADPRAGAARTWNEVDALGYGDALSPAEHGGAGLSLADAEGLLRAAGAMALPFPFADTLLARALLRAAGQAVPDGPIALGVALPHGADWRCAPIAGVALAQAVAVEHDGCLALWPAPDVVQPGLFRPRASGAPAWRGMPAQAGRAGAPAGAVQAWRNAADAAGMAGAMQAVLDRCVAYVQERQQFGRALGRFQAIQQDISMLAEQVAAVAMAARLACASGALFPDPALAACARLRACEAVPVVCALAHAVHGAIGITEELPLGLYTARLHEWRATGMSEDDCAELLGRRVLADGERTLLDVVRGMVSAAQA
>NZ_CP020818.1|WP_033450541.1|4556752_4557946_-|acetyl-CoA-C-acyltransferase
MSVHPDPVVIVAARRTPIGAFQGALAHYSAPQLGAHALAAAVRQAGLQPDAAQEALMGCCLFAGLGQAPARQAVLGAGLPTDVQATTLSKMCGSGMKAAMLAHDMLRAGSADVVLAGGMESMSNAPHLIPKARQGYRLGDGQLLDHMYRDGLQDAYEGRLMGHYADLAAREYGFSREQQDAYAHESVLRAQRSVAEGEFAEEIAPMAGLARRGAPAAMVAVDETPGLCDVSRLASLKPVFNADGTVTAGNASSISDGAAALVLTRQAHAERLGLAPQARIVGHATAALPPGQFPAAPVRAIARLFERVGWNRDSVDLFEINEAFAVVTMIALRELGLPAERVNVNGGACALGHPVGATGARLIVTLMHALRRRGLRRGVACLCLGGGEATAIAIERA
>NZ_CP020818.1|WP_003814701.1|4568500_4568971_-|universal-stress-protein
MFKKILIPTDGSPLSAQAANAGICFARSTGAEVVALHVTQPFAATIGFDGMAAAYAITDEDYEKASAEQAEKYLKLILDRAETAGVKAESRAVSNFNVADGIVQAAGEAGCDLIFIGSHGRSGLSRLLLGSVTAKVLSLAHTAVLVYRVKEDKDKK
>NZ_CP020818.1|WP_003820700.1|4569059_4569404_-|TIGR01244-family-phosphatase
MSAAIKPLTENFAVAPQLGPADMADVAAAGYKSVIINRPDFEGGPDQPTAADVSQAAQALGLQVEYQPVVGSAMTAADVARFAELLRTMPGPVLAYCRTGTRCTNLFAAAQQLG
>NZ_CP020818.1|WP_003814704.1|4569503_4570904_-|PLP-dependent-aminotransferase-family-protein
MRQADATLVTQLADDLARRIDEHGLRPGTRLPSIRRMAEQSGVSRFTVVEAYDRLVARGLVQSRRGAGFFVRARSASLTALASARVPQAAPETPVRVDVSWLLRNMFRETAAGMPGGAGLLPPEWLDPDMVAAAVRAVGRTVRGNLVSYGSPQGYAPLRQQLASMLQADGVPAHPERNLLTTNGVTHGLDIVARHLIKPGDTVLVEDPAWFVIFGRLAAFGARPVGVPRGPDGPDLAMLDRLAAEHKPRLYIINGAVHNPTGHTLSAGAAYDILRLAERHDFMVVEDDTYADLHPGGAMKLAALDRLERVILVGGFSKMLAASLRVGYIAAGAETLQRLTDLKMLAGLTSPELGERVVHRVLVEGQYRRHIERVRARVNEARLRSIQALQQLGLSVPHEPHAGMFVWADCGRDSEPVARNAAERGMLLAPGTLFSPSGAPSTMLRFSVAMVDTPGIWQSIAAVMAQ
>NZ_CP020818.1|WP_003820699.1|4571092_4572007_+|DMT-family-transporter
MSPPSAQASAPSASSHAPSWEGYGYGLIGVLVFALTLPMTRLAVGELSPLLVGLGRALLAAVPAAALLWLTRSRRPDRAEWSGIVLAAVGIVVGWPVASTLAMASVPAAHGAVFNGLLPLSTAVFAAWRSGERPSPAFWSFAVLGAVLVAGYALRQGHGALQPGDLWLLLAVVLGGMGYAEGARASRTLGGWRTICWALVVSVPALLPAVLWLAHDAAWPSLPVAGAFAYLAFGSMFLGFFAWYRGLAIGGIARVGQIQLLQPFLTVVAAALLFNEQVEPITYVFAVAVVLVIAGGRRAMVRKA
>NZ_CP020818.1|WP_003820698.1|4572003_4572663_+|LysE-family-translocator
MIGSDLSSLDQAPLASLSVLMPLVLFTLVNSLTPGPNNVMLASSGLTFGFRRTIPHLLGISVGFSIMLLMVGLGLGATLERLPWLYSTLKYGGAAYLLYLAWKIATSGPMESGAERGKPLTFIQAALFQWVNPKAWVMIVSVVATYTPQHGYFANLIIATLVCGVVNLPSVGVWAAFGMALRRWLHRPAAVRTFNVGMAVLLVVSLYPVGLDLLALYTG
>NZ_CP020818.1|WP_003814709.1|4572752_4573676_+|alpha/beta-fold-hydrolase
MVSLPFRLSWRRMAAVLLLAAGALGFNQLDAWQRQAIFSPQTDQQRWWREPPAGTEVFDLALPNGDKVHAWYWQSPRRDAPTVLYLHGARWNLNGSAFRMEGWTRMGYSMLAIDYRGFGQSTPLLPSEQSASQDAAAALQELARRQPDPARRFIYGHSLGGAIAIDLAARPDLPPFAGLIVESSFTSIGAMLGTMKWGWVPGATLLVTQPFASVDKLAALTTPMLLLHGTADRVVPHTMSDELYRAAQQVPADLKRLVKIEGASHSGAIRSGRIYEDAVADFVRDAGRGYAGRQGAPTPLTASRPGT
>NZ_CP020818.1|WP_003814711.1|4573681_4574137_-|multidrug/biocide-efflux-PACE-transporter
MSSSSKQTPKTIKERFLHAFFFEIIAIGLSAPVAAWAMDQPLFDMGVLTAVIAWIALLWNMVYNAGFERLERRFGVVRTMPVRVAHAVGFELGLVLIIVPLAAWWLAISFWEAFMLDIGLLMFYLPYAFFYNLAYDKLRARWWGRIEPAGA
>NZ_CP020818.1|WP_033472576.1|4574133_4575237_-|ChbG/HpnK-family-deacetylase
MTSERYDEGQQPAHHVGPQRGQAGPFHAGDRDGPMGGGRGASDGNEPGNLSQQAAHVEVVSPLRNQAGDVRCRRIAVCGDDFGMNEAIDGALIELAGAGRLSAVSCMPLAPAFAADAPALARLDVDLGVHVDFTEAFAGAAPAAPGLTALLWRAYAGQLDPDWIDARLASQFDAFERAFGRAPDYVDGHQHVHQLPGILPRLRALLKRRYAGQRIWLRHTAPGLQFGLPLAQAAKARLIGALGAGALARAAGQEGWQTNRRMLGVYDFTGGPRRYAGLLHHWLMNARDGDLLMCHPGWPQVHGAAHASQRAAEYEVLAHPELGTWLARNGLRIVRLSQVRGRQASQESGKVRNVPHSGSFRRLASRL
>NZ_CP020818.1|WP_157734656.1|4575195_4575465_+|hypothetical-protein
MGWLLAFVVSFTGHFRLTFRHLAASWTIAARRFFLVSALGFAINELSYAWLLHATSLPYDVLLALVLIGLAFLTFVASRLWAFRHRHAP
>NZ_CP020818.1|WP_033461063.1|4575424_4577044_-|glycosyltransferase-family-39-protein
MTLATRSMQPHAVSPGQARSWPLPAAGWLLLAVGVWLAFLSWMRPLALPDEGRYAGVAWDMLRNGSFAVPLIDGMPYFHKPPLYYWLAELSFRLFGVNEWAARLPSALAAWASAVALYLFVRRHRDAASATLCVLVLATLPLFFGGAQYANMDMLVAGMITLCVLAGADTALRARAGQAWRAMALATGVCAALAMLAKGLIGLVLPGAVLLAWLAWRRDWRGLRVLLWPPAILAFAVVAVPWFWLMQVRYPGFFEYFFVHQHFERFAQTGFNNVQPFWFYLPVIAGLALPWSLWAGGLLRKQFWAADADPDGLRRLALVWLAVIVAFFSMPQSKLVGYIMPVLPPLAFLLAEVVMGALRDPAVARATRRMARVSALVAVAICVTAVFVASFNARGSSRELALSLRGELRPDDTLVALHTYPFDLQLYAHAARPMWVVDDWSNPEIPKRDNWRRELYDAVQFEPALGERLLVSADTFQQRLCQAPEGSRYWVWGTAADEEAYAPLRGQAARFADARRSLWLVLVDEAFKGRVCDGTPTGG

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Crispr_ID: NZ_CP020818_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP020818_8

5033454-5033549

Orphan

Consensus_repeat	Method
TGACGGCCAAGACGGTATCCGCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP020818_8

>merge|NZ_CP020818|8|5033454-5033549|CRISPRCasFinder
TGACGGCCAAGACGGTATCCGCCCCGGCGGGAATCCCGGTGCCTGTCCCTGCGGGGACAGGCACACTGCCATGACGGCCAAGACGGTATCTGCCCC

>NZ_CP020818|8|8|5033454-5033549|CRISPRCasFinder
TGACGGCCAAGACGGTATCCGCCCC	GGCGGGAATCCCGGTGCCTGTCCCTGCGGGGACAGGCACACTGCCA
TGACGGCCAAGACGGTATCTGCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP020818.1\|WP_003817939.1\|5040580_5041735_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238425
NZ_CP020818.1\|WP_003817938.1\|5039777_5040584_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|223955
NZ_CP020818.1\|WP_003817926.1\|5027971_5029147_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP020818.1\|WP_033469045.1\|5029152_5030418_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP020818.1\|WP_003815548.1\|5042134_5042530_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP020818.1\|WP_003817930.1\|5032197_5033169_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|238958
NZ_CP020818.1\|WP_042996954.1\|5042526_5042919_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239525
NZ_CP020818.1\|WP_003817920.1\|5023697_5024906_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380558
NZ_CP020818.1\|WP_033469049.1\|5034485_5035262_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP020818.1\|WP_003815515.1\|5022743_5023628_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NZ_CP020818.1\|WP_080605885.1\|5020923_5022747_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|213186
NZ_CP020818.1\|WP_003817941.1\|5041736_5042138_+\|Zn-ribbon-domain-containing-OB-fold-protein	unknown	unknown	gnl\|CDD\|224462
NZ_CP020818.1\|WP_003817928.1\|5030421_5031207_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|223955
NZ_CP020818.1\|WP_110129127.1\|5033623_5034409_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP020818.1\|WP_110129126.1\|5031221_5032196_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP020818.1\|WP_110129128.1\|5035258_5037391_-\|acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|131764
NZ_CP020818.1\|WP_110129129.1\|5037392_5038385_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP020818.1\|WP_015041996.1\|5024980_5026378_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377179
NZ_CP020818.1\|WP_003817936.1\|5038632_5039781_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP020818.1\|WP_003817924.1\|5026398_5027892_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|102207

Protein	Function_ID	Function_description	E-value
NZ_CP020818.1\|WP_003817939.1\|5040580_5041735_+\|thiolase-family-protein	gnl\|CDD\|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	4.50908e-123
NZ_CP020818.1\|WP_003817938.1\|5039777_5040584_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|223955	COG1024, CaiD, Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism].	2.06389e-73
NZ_CP020818.1\|WP_003817926.1\|5027971_5029147_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	7.67701e-96
NZ_CP020818.1\|WP_033469045.1\|5029152_5030418_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.08307e-132
NZ_CP020818.1\|WP_003817930.1\|5032197_5033169_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|238958	cd02000, TPP_E1_PDC_ADC_BCADC, Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).	2.48882e-127
NZ_CP020818.1\|WP_042996954.1\|5042526_5042919_+\|MaoC-family-dehydratase	gnl\|CDD\|239525	cd03441, R_hydratase_like, (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel beta-sheet wrapped around a central alpha helix, referred to as a hot dog fold. The active site lies within a substrate-binding tunnel formed by the homodimer. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit.	1.97384e-21
NZ_CP020818.1\|WP_003817920.1\|5023697_5024906_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380558	cd06335, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	7.41648e-136
NZ_CP020818.1\|WP_033469049.1\|5034485_5035262_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.72923e-33
NZ_CP020818.1\|WP_003815515.1\|5022743_5023628_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.70951e-58
NZ_CP020818.1\|WP_080605885.1\|5020923_5022747_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	4.27973e-96
NZ_CP020818.1\|WP_003817941.1\|5041736_5042138_+\|Zn-ribbon-domain-containing-OB-fold-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	6.80556e-24
NZ_CP020818.1\|WP_003817928.1\|5030421_5031207_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|223955	COG1024, CaiD, Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism].	4.86287e-76
NZ_CP020818.1\|WP_110129127.1\|5033623_5034409_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.88183e-48
NZ_CP020818.1\|WP_110129126.1\|5031221_5032196_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.04152e-169
NZ_CP020818.1\|WP_110129128.1\|5035258_5037391_-\|acetate--CoA-ligase-family-protein	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	6.89073e-117
NZ_CP020818.1\|WP_110129129.1\|5037392_5038385_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	7.88147e-138
NZ_CP020818.1\|WP_015041996.1\|5024980_5026378_-\|hypothetical-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	1.77503e-65
NZ_CP020818.1\|WP_003817936.1\|5038632_5039781_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	2.8877e-124
NZ_CP020818.1\|WP_003817924.1\|5026398_5027892_-\|AMP-binding-protein	gnl\|CDD\|102207	PRK06145, PRK06145, acyl-CoA synthetase; Validated.	0

>NZ_CP020818.1|WP_003817930.1|5032197_5033169_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MARANKEQLLDAYQRMLGIRLVELRLGRLFADGEVPGFIHLSVGQEAVAAAMGMVLRPDDTVASTHRGHGHALAKGIDMDDFFLELMAREEGICKGRGGSMHVANMSIGMLGANAIVGASIPIALGSALAHQVRKTDALAVAFFGDGAMAEGVLHESLNLAALWQLPLLFLCENNGWAEFSPTHKQFVAPLDKLSAAFSIPHAKVDGNDVLAVMDAAQAAVADIRAGKGPRVLECITHRWRGHYEGDPQKYRDSDEISGLDEHDPVARFEAVLDSKGVSQAQRQKVRDAVQAQVDQAVERARKGRPPVWETARTDVYTQAEAR
>NZ_CP020818.1|WP_110129126.1|5031221_5032196_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAELRFAHAINRALAECMEEDPMVFLFGEDIAEAGGPFGVTRGLHDRFGSDRIRDTPISEATMANAAVGAALSGLKPVLEIMFMDFMTLTMDALVNQAAKARFMFGGQASVPMVVRTPHGGGISAGPQHSQCLEAWFAHIPGLKVVCPSNPADAYGLLKSAIRDPDPVVFVENKALYAAKGEVPDDAGPIPLGQARIARAGRDLTVVSYGAMVHKVERAAEALARDGIEAEVLDLRSIQPWDEAAVLASLRRTHRLLVVHEAVEAFGVGAEIAARMADIGFDELDAPIVRVASPFVPVPFAPSLEAQYQPQEADIIAAARKLCA
>NZ_CP020818.1|WP_003817928.1|5030421_5031207_-|enoyl-CoA-hydratase/isomerase-family-protein
MSEQSILTEVRDHVGIITINRPKLHNALDTPTLLELERALTTLEADAECRVIVVTGAGEKSFVAGGDLVDLNSRQGLAHYQEFAEDIHRVFRRFETSDKPTIAAVNGWALGGGTELLLCLDLRIVADNAAIALTEVNLGLFPGAGGTQRIIRQISPCQAKEMMFTGGRISAADAVRIGLANRAVPAADLMAETLALAGQIAAKSPLVLKLLKRTLRDGADMPLANALAHEQAMIGLVLDTRDAHEGIGAFLEKRAARFTGQ
>NZ_CP020818.1|WP_033469045.1|5029152_5030418_-|2-oxo-acid-dehydrogenase-subunit-E2
MSQLNDLLMPKLGLTMTEGMLIEWSVTSGAEVKAGDSLFVVETDKVANEIVAQADGTLAEILVAAGETVPVGTVVARWTGPGQGADDMADAPPAPAPAAQPAAEAAEAAPAVARQPARGGRVVATPLARRLAREAGLDLAQVSGSGPGGRIKAADVRQAPRAPEAAPAVSPDTAAPAPAARAPLAPVAGERRIEASALVQSMARRMTQAKQVPHFYLSAEAEVSALLALRQRLNAQADAPRLTLNHFVIAAVARALAAMPHQNRIWNDDHIVQFQGIDVGVAVSTERGLMAPVLHGLDHASLDDIAAQSDALLGRVRAGKATREDMSGGAISISNAGMFNVTYMAPIINPPQSAILGVGSIRELFRPDEQGAPALRREMGLVLAADHRLHDGASALAFLNHVIDLLQDPYRLLRNRPHTKG
>NZ_CP020818.1|WP_003817926.1|5027971_5029147_-|acyl-CoA/acyl-ACP-dehydrogenase
MDFSLSDEQKLIVETARRIGEDYGVDYWHDLDRRKAFPQECWQAICDAGLAGAALPQEHGGSGLGMLDLALIVEELSAGGGGATLGQLFMINPIFGGVPISKFGSEQMKRELLPALVGGKMNFCMALTEPDAGTNTLAMKSYAEAEPGGGWRLNGRKIWITAVDAAQKMLVVARTSRQTEGARPSDGISMFIIDVEREGLSYSAIDKVGTQTLSACSVFFDNVRIEPHELVGTLDKGFRELLDVLNTERIVTTASLIGAGRLAKRLAVQYANDRKVFGGKPISSYQGLQFPLAQSHAELQCARLMNLKAAALCDQGLPYGTEANIAKLIGSQAASHAIERSMQTMGGMGYAREFHVERLWRDARLFKFAPVSEEMILNYIAIHDLGMPKSY
>NZ_CP020818.1|WP_003817924.1|5026398_5027892_-|AMP-binding-protein
MFNLSASIAFHARRTPDKAAIVYRDQEIGYAEFHQRILQAAAMLHARGIGQNDVVALFMKNSAAFLELAFAASYLGAVFLPVNYRLAAPEAAYILGDAGAKLLLVDEEFDAIVALETPKIVIDAQAQADSRRLGQPGLEIPPQAAVAETDLVRLMYTSGTTSRPKGVMHSYGNLHWKSIDHVIALGLTASEKLLVVGPLYHVGAFDLPGIAVLWVGGTLCVHREFDPEAVLASIERHRLTCGWMAPVMLSRVLTVPDPDRFDLDTFAWCIAGGEKTPESRIRDFTRVFTRGRFVDGFGMTETCSGDTLMEAGREIEKIGSTGRALPHVEIRIADGAGGWLPANQKGEICMRGPKVTKGYWNAPEKTAEAFYGDWLRSGDVGYLDEEGFLFVTDRTKDMILTGAENVASSEVEAALYELPQIAEAAVIGVHDDKWGERITAVVVLNPGQTLTLEEIDRHCRQRLASFKVPRELKVVAELPRNPSGKVLKRVLRDEYNG
>NZ_CP020818.1|WP_015041996.1|5024980_5026378_-|hypothetical-protein
MPPHRTHRTRRHPMTLAQRFARFAANLELDTIPAPALDKARACVLNGYGIALGSHPTPFFGVAERAVLAMDGEREDGATLLGSGRRSTVAGAALANAALFHGRAQEDTCGVAHFGAILLPLLTALVERGEGRIEDFLPALVAGYEVGGALEAAYSPLTTAAGLRASPLYGTVAAAAAAARLWRLPEDRTAAALANAASFAGGILQSFGDGTDEWRYQVGMAGRNGLAAATLAASGSVSAAGAFEGRSGFVRAFVRTECDVDAIAGQLGKDWSILKVTFKPYPVCALNQTPVRASLALREQLGAQADAVRAVRIHLNPTVVGYAGMDKEGPFESVSGTLMSIQFCVATTLLHGAPTIAHMTAFDDAGVLGLIPRIRPLADPALGLLSCRIEADVDGRAEPVVVQMHTDHTEYSYDRAGVSALVRRIGAETGVAPSAYDHIEKFAQALPHADLGDVLAAFGTIQTAR
>NZ_CP020818.1|WP_003817920.1|5023697_5024906_-|ABC-transporter-substrate-binding-protein
MSWYRKSTTCLAVAAAVLASGAALAADTIKIGMTSALTGPYNEFGEGNRRAVELAVEQWNAKGGINGKKIEIAMLLDDQLNPDRAVQNIRAILDNKDIVGIIGPAGSGPTLAVIDMVQADGRPYMNPIAQTPVVTYPGEKTGEKPRPNVFSFALQNDIEAVAMGEYLAKKFKRVGIIHESTAYGVTGVDYLAASIAKNGGAKPVATDSYNQGAQDMTAQVARMKRANVDAIAAIGLGKDLAVLRRTMARLNVNVPLVASNGALGQPYQEGAGELTLGTLGTMIGAFGNPMRAPAADFAKAYKAKYGTDRWWGNDPENPQLFMAISVSNGYDAANILFEGIRLANSTDPKAVIAAIESIKDYQGVNTAYTFSKERHHGIETDGVKVFEYVKKGDKIRLEPIAQ
>NZ_CP020818.1|WP_003815515.1|5022743_5023628_-|branched-chain-amino-acid-ABC-transporter-permease
MDFFIQMIVSGLSVGAVYALIGLGLNLTFWTTRVLNFGQGSVLMAGAMLTAVMVGAGVNVFLAVGVSLLVTAFILWIVELVGVRPMRRMSGSMGWVVSTLGIGIFLQGMASWLFGTQAVAFPDVLFSSADTVEFMGAYISLQYIAVFVISVMIVCLMELFLRHSIWGYGVRAVAHDRDLAALMGIPVYRVVVFSFLVSGVLAGIAGILVSQVSGTVDPNFGLHLLILAFVAAVVGGMGSAFGSLVGGLILGIMEKLVGGYVSPAAAEVVAFVLLIGVLTIRPQGLFGKRETVKV
>NZ_CP020818.1|WP_080605885.1|5020923_5022747_-|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein/permease
MRPMKLLGQLLTNSWTLGVLAIALAVGAGHADTGTVQMWSFVIINILLAQGINLLTGINGQISLGHAGFFAIGAYVSAIALKSWGVPFPVALAMATIVASGVGFLLAGPAGRVREFYLAMMSLGFGLIVYELARELRGVTGGVMGMRGIPSSQIGTLQIFGWSIDTVAYFRILLAVLLVVMLMLRNFVKSHYGRAFYAVHVSEIAAGSLGISQAAVKRAAYAISGGLAGLAGGFYAHMIGYLTPESFGLMRSIEILVMSIVGGLGSLAGQVYGAVLFTYLPQKLQAFNDYQYIVYGLILVFIFTLLPRGLAGLLGTQTRYSKYDQLRRAVAGQPAAPLGERPPHARGDAAQPLIRVEQVVMEFAGLRALAGVSLDLHAGSITALVGPNGSGKSTLVNVVSGIYRPTSGRVLYKGQDIAGWPSHKVAQAGITRTFQDPRNVPSFTVRENILMGAHRRYRHGALAAAVNTAGARREEAAFLRQVDALMQAAGLSEHADAIMSELPYGIQRLAEVARALASDPELLLLDEPAAGLSELESGHLIGLVRLARDHGVAVMVIDHHMDFLAELAEDVVVFEAGDEIYRGDMDGMRADPAVIQAYLGAEEPAHA
>NZ_CP020818.1|WP_110129127.1|5033623_5034409_-|IclR-family-transcriptional-regulator
MAAEPPEKLVGALVGGLRVLRYLSAAPAGVGVTRVARDLQLNSSTCYNFLKTLVYEGLVTFDESTKTYSIALGLVELAKGVLEQGAYVRLIHPHLEEIARAHRVTATLWQRTSNERVVLVDRADNDSSVRVHMSVGQRLPMYIAALGRCMAANAGLDRDQLEQRFDALRWDDKPPFDEYLAGVEEARKNGYATDAGHYVKGVSTASAAVLDAFGKPVMAISAVGFSAQFTGDALEQLGEDLRERAGRITRALSGGRAGADS
>NZ_CP020818.1|WP_033469049.1|5034485_5035262_-|enoyl-CoA-hydratase/isomerase-family-protein
MSAAANPVRVEDAGGVRAIVLDRAAKANALCAAMLDDIRHAIERAPRDGIDLLVLRSAAPTLFCAGGDIEEFALGAAALERQGAALRELMAAMARCPLPLLAVARGKAAGAGVILLAMTDLVIAAQDLSLACPEMAFSMYPVIVQAALETKISAARARQLCLSGQVLDAAAARDLGLVTDVLGLDGFDALAERRLAYYAGRRAALAIARKARLAMEPPDAVVARVRALEPLMHENFRIPGVQETIQHYLAGLRTRRAG
>NZ_CP020818.1|WP_110129128.1|5035258_5037391_-|acetate--CoA-ligase-family-protein
MTQDLDMAERSVAAPQWQGAARAAAVLEARSVAIVGASADPGKIAGRPLAYMLSRGFVGKLFPVNPTRAQVQGVKSYPSLAAIGEPVDLAIVGTPAALVEGVIREGIAAGVRAFVVFSSGFSETGEAGAALQRRLGELARAHGVTILGPNCLGVANSATGLIASFTTALEETPIRPGGFALVSQSGALGAYWMDICLRSGLGFSKWITTGNECDMDAAAAIAYLAGDADTRVIGLYIEDIRDTAAFRRALRVAAEAGKPVIAIKAGRSQAGAAAAASHTGALAGDDALYDACLRQHGALRVDSLGQMMDAARLYLFDSVPQGRRIAVMSVSGGAGVLIADEAERCGLVLPPLAEATASALAPVLPSFVQAANPLDLTGNVVQDTASIGQALEAVARDPGNDAIVLFVGLMHSIASAFTDAIAQARQRTHRPIIVIWIGAKEESVAALEQARIPVFRDIPPAVAAVGAAVRLQALREAALAMALPAAAPPAARAGRIEALAECDGKALLRELGAAGVPAGVLVAGPAPERLPAPLAYPVVAKLQAASLLHKSDIGGVVLGIASDQQLREAVQRLGDIAREHGIEARGVLVEPMQPFDHELLLGLRRDPRFGATLTLGRGGVEVELDADVASQLLPLSAGAIQAMLESLRAARLFKGFRGRGAVDLAALSSQIADLCRIFLEQPDLAEVEINPLAVRGDRAWVLDAVVSRYA
>NZ_CP020818.1|WP_110129129.1|5037392_5038385_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MNIGTSFPRISSRLAGALLAALAVAPVQAYAQQAYPSKPIEIIVASSAGGILDTIARTAAHGLERLGQSAVAKNLPGGGGTIATAALARMPGDGYTLGAVATSHAINPNIYNKLAYDTGRDFTNITQMVELTNFLVVNPSVPASNLKEFIALAKAKPGTLTYGSAGVGQSNHLSGELLQQDAGIKLVHVPYRGSAQALTDVIGGSVSAMFVDALSAEPYVKAGKLKLIAATGLARSPAYPAYPTLAESGLPGFNGNTWLGLVAPAGVPKDIVAKLQDAVRAEFEDPDVRKRLISQGVIPVASTPQAFSAFLDSEMKRWAEVIKVAGIEAN
>NZ_CP020818.1|WP_003817936.1|5038632_5039781_+|acyl-CoA-dehydrogenase
MSLSFAFSSEHEAVRDTVRRLCQEELAPLVFEAEEQEAFPRRVFERWGELGLLGVRYPEADGGSGLDKVSDCIVREELSYLSQAFASTWSAHTHLGIWPIWKAGTPAQKARFLAPALAGRKVAGFGLSEPDGGSNVRAMKTRAERVEGGWRLHGSKLYITNAPFADFLLVAARTSAALKPESISLFIVELPNAGFDIAKLKKEGIRASETALIHIDNAFVPDDCLLGETEGTYPLILESLSENRVGVAANALGMARAAFDAAAGFANDRLVAGKRVGEYQAIAHKLADMSAQIEATRWLVYYGAWRVDQGTLDAATAARVKLVASETAVAVSEQAIRIFGGAGIMREYPVGRIHRDALVYVIGEGTSEIQKNIIARSLGFKP
>NZ_CP020818.1|WP_003817938.1|5039777_5040584_+|enoyl-CoA-hydratase/isomerase-family-protein
MSDYVLRERRGATFVITLNRPERRNAFDLEVRQSLAEAIFEARDDDAVKAVIITGTQGVFCAGGDLKSLSDGKRPIYQDRDRIRRLHTWFHELVNLEKPVIAAVDGPAFGAGFNLALACDFILGTPAARFCAVFGRIGLVPDLGGFFLLPRIVGLQQAKELVFTAREVGADEARALGILYRVVPAPGLLDEALALAARFHSASTLALGMSKNILNRSFNLDQNTLAELESHAQALAIHSEYHEAAVARFLDKQPLPFSWPGEDKDGQS
>NZ_CP020818.1|WP_003817939.1|5040580_5041735_+|thiolase-family-protein
MSMNAFITGASDTSVGELPGSSCMGLHAEAAFGAIADAGLEPGDIDGVLCAYSFTEPHLMLGSVFCEYTGIHPGFCTAVQAGGASACIMIMQAAALVASGQCRHVLVVTGDNRLTGLSRDGAVAALAEVGHPQFERPFGISVPASYALVAQRYMHEYGATPEHLAAIAVEHRRHAGRHPKAHKRDPISIDDVLNSREISTPLRLLDCCLISDGGAALVISSRAASAASSKRSVEILGAGQGHTHEHIVAAPSLTDFGCKASSARAFAAAGVRPADIDVAQIYDSFTITLLVELESIGFFERGQAGPAALQGQLGLGGALPCNTHGGLLSYGHSGAAGGMFHAVEAVHQLRGQADQRQVDGARLAFVHGDGGILSAHCSLVLGAA
>NZ_CP020818.1|WP_003817941.1|5041736_5042138_+|Zn-ribbon-domain-containing-OB-fold-protein
MEKPPITPNAESLPFWQGCRDHRLRYQQCASCGTVQRIPRAVCTHCHGRALQWRDSAGQGVVLSHTTVRRAPTPAFKADTPYAIALVDLDEGFRLMVNVRGGADAPLAIGARVRIVFEARGDGAVPIAEMETP
>NZ_CP020818.1|WP_003815548.1|5042134_5042530_+|hypothetical-protein
MTQLYTYETFTPGTVLGEWAEPLDARLVATWERLFGAEARDQPARQVGLTVALMIRAYLNVVTPRPPGNIHAQQILSIDGLPGVGETVRSRIRCLGKEIRRERRYLQLEVSGVGERERNLYTGRMNLIWAA
>NZ_CP020818.1|WP_042996954.1|5042526_5042919_+|MaoC-family-dehydratase
MRNTMTQRLEEVSMRVTQADIDIYAELTDDFNPLHVDPAFAATTPMGGTIAHGTLSVNLIWQSLARSLGAAALARIDLDIRFLKPLFAGGAITAGGQPDAAEPDRYEVWVKGADGAILIAGHARLAPITD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP020818_3	3.1\|1407035\|36\|NZ_CP020818\|CRISPRCasFinder	1407035-1407070	36	NZ_CP020818.1	731336-731371	0	1.0
NZ_CP020818_3	3.1\|1407035\|36\|NZ_CP020818\|CRISPRCasFinder	1407035-1407070	36	NZ_CP020818.1	4811004-4811039	0	1.0
NZ_CP020818_3	3.1\|1407035\|36\|NZ_CP020818\|CRISPRCasFinder	1407035-1407070	36	NZ_CP020818.1	1548940-1548975	1	0.972
NZ_CP020818_3	3.1\|1407035\|36\|NZ_CP020818\|CRISPRCasFinder	1407035-1407070	36	NZ_CP020818.1	3581449-3581484	1	0.972
NZ_CP020818_3	3.2\|1407097\|17\|NZ_CP020818\|CRISPRCasFinder	1407097-1407113	17	NZ_CP020818.1	2187595-2187611	1	0.941
NZ_CP020818_3	3.1\|1407035\|36\|NZ_CP020818\|CRISPRCasFinder	1407035-1407070	36	NZ_CP020818.1	1479824-1479859	2	0.944
NZ_CP020818_3	3.1\|1407035\|36\|NZ_CP020818\|CRISPRCasFinder	1407035-1407070	36	NZ_CP020818.1	4860231-4860266	2	0.944

1. spacer 3.1|1407035|36|NZ_CP020818|CRISPRCasFinder matches to position: 731336-731371, mismatch: 0, identity: 1.0

ccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
ccgtacgccatcgacgcttgaccgccaagacggtat	Protospacer
************************************

2. spacer 3.1|1407035|36|NZ_CP020818|CRISPRCasFinder matches to position: 4811004-4811039, mismatch: 0, identity: 1.0

ccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
ccgtacgccatcgacgcttgaccgccaagacggtat	Protospacer
************************************

3. spacer 3.1|1407035|36|NZ_CP020818|CRISPRCasFinder matches to position: 1548940-1548975, mismatch: 1, identity: 0.972

ccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
ccgtacgccatcgacgcttggccgccaagacggtat	Protospacer
********************.***************

4. spacer 3.1|1407035|36|NZ_CP020818|CRISPRCasFinder matches to position: 3581449-3581484, mismatch: 1, identity: 0.972

ccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
ccgtacgccatcgacgcttcaccgccaagacggtat	Protospacer
******************* ****************

5. spacer 3.2|1407097|17|NZ_CP020818|CRISPRCasFinder matches to position: 2187595-2187611, mismatch: 1, identity: 0.941

gccggcgggccaggatc	CRISPR spacer
gccggcgcgccaggatc	Protospacer
******* *********

6. spacer 3.1|1407035|36|NZ_CP020818|CRISPRCasFinder matches to position: 1479824-1479859, mismatch: 2, identity: 0.944

ccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
ccgtacgccatcgacgcttcgccgccaagacggtat	Protospacer
******************* .***************

7. spacer 3.1|1407035|36|NZ_CP020818|CRISPRCasFinder matches to position: 4860231-4860266, mismatch: 2, identity: 0.944

ccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
ccgtacgccatcgacgcttgacggccaggacggtat	Protospacer
********************** ****.********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP020818_1	1.1\|425112\|23\|NZ_CP020818\|CRISPRCasFinder	425112-425134	23	NZ_CP021368	Acidovorax carolinensis strain P4 plasmid pACP4.2, complete sequence	59210-59232	3	0.87
NZ_CP020818_1	1.1\|425112\|23\|NZ_CP020818\|CRISPRCasFinder	425112-425134	23	NZ_CP021364	Acidovorax carolinensis strain P3 plasmid pACP3.2, complete sequence	78286-78308	3	0.87

1. spacer 1.1|425112|23|NZ_CP020818|CRISPRCasFinder matches to NZ_CP021368 (Acidovorax carolinensis strain P4 plasmid pACP4.2, complete sequence) position: , mismatch: 3, identity: 0.87

aagcgtcgatggcgtacggcagc	CRISPR spacer
gggcgtcgatggcgtagggcagc	Protospacer
..************** ******

2. spacer 1.1|425112|23|NZ_CP020818|CRISPRCasFinder matches to NZ_CP021364 (Acidovorax carolinensis strain P3 plasmid pACP3.2, complete sequence) position: , mismatch: 3, identity: 0.87

aagcgtcgatggcgtacggcagc	CRISPR spacer
gggcgtcgatggcgtagggcagc	Protospacer
..************** ******

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2277886 : 2286076

Moraxella_phage(28.57%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003816536.1\|2277886_2278474_+	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	2.8e-16	35.8
WP_003811007.1\|2278491_2278875_-	thioredoxin family protein	V9SJ74	Achromobacter_phage	8.1e-09	25.8
WP_003816534.1\|2279010_2280036_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_003811011.1\|2280241_2281534_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.7e-66	36.0
WP_033459819.1\|2281668_2282709_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	9.3e-92	51.6
WP_003811015.1\|2282878_2283526_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003816529.1\|2283651_2284410_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	8.1e-69	51.2
WP_003816528.1\|2284484_2285174_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	3.2e-32	46.9
WP_003811022.1\|2285191_2286076_+	peptidoglycan DD-metalloendopeptidase family protein	A0A292GJG6	Xanthomonas_phage	4.6e-15	49.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP020818

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection